LOCUS       DAEHWM010000001       148876 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.001, whole genome shotgun sequence.
ACCESSION   DAEHWM010000001 DAEHWM010000000
VERSION     DAEHWM010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 148876)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 148876)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..148876
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.001"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(130..324)
                     /locus_tag="KNP36_000001"
     CDS             complement(130..324)
                     /locus_tag="KNP36_000001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871905.1"
                     /translation="MFQVINFLCLFCVGFLVLDVMIYFCKDAMDIFEGTTNVNKVKSI
                     NVWADRVRANSYSYENKIAK"
     gene            complement(633..2162)
                     /gene="lysS"
                     /locus_tag="KNP36_000002"
     CDS             complement(633..2162)
                     /gene="lysS"
                     /locus_tag="KNP36_000002"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HBF0871906.1"
                     /translation="MKNNQQSNEEAQIQEDLSEVLQVRRDKLKKLQESGRDPFKESRY
                     DRTHYSMDIKDNFDSLEGKTTKIAGRIMSKRIQGKAGFIDIQDQEGRIQSYVRLDAIG
                     EEEYSVFSTYDIGDIVGIEGEIFKTKKGEISVKAKSVVLLCKSLQVLPEKYHGLKDQE
                     LRYRQRYVDLIVNPEVKNAFLIRTKALKALRAYLDDRGFLEVETPILNTIAGGANARP
                     FITNHNTLHIPMYLRIANELYLKRLIVGGFDKVYEMGRMFRNEGMDLKHNPEYTAIEL
                     YQAYADYTDMMEITENVIAHMAEVATGSMIVNYQGTEINFTPPWKRMSMEDCVKEYSG
                     VDFSTINTDEEALEVAREKGIEIKPGMRRGEVINAFFEEFGEDKLIQPTFITHHPVEV
                     SPLSKRNVEDPRRTDRFEAFANKWELANAFSELNDPIDQKGRFIDQLRKRELGDDEAF
                     EMDEDFLKALEVGLPPTGGLGIGIDRVIMLLTNSPSIRDVLLFPTMKPIDNNPNKEEE
                     N"
     gene            complement(2177..2656)
                     /gene="greA"
                     /locus_tag="KNP36_000003"
     CDS             complement(2177..2656)
                     /gene="greA"
                     /locus_tag="KNP36_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003514606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HBF0871907.1"
                     /translation="MEENKEFLLTQEGYDKLEEELENLKVVKRKEVAERIKVAISFGD
                     LSENAEYDEAKKEQAQVEERILKLENMVRKAVIIDESKIDLNVVTIGSIVKVKDLEFD
                     EEVEYTIVGSTEADPYDGKISNESPVGKALLGRAAKEVVEVQVPDGVAKFEILEIRR"
     gene            complement(2765..3733)
                     /gene="dusB"
                     /locus_tag="KNP36_000004"
     CDS             complement(2765..3733)
                     /gene="dusB"
                     /locus_tag="KNP36_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HBF0871908.1"
                     /translation="MKIGNLELKNKVFLSPMAGVTDLPFRLICKEQGCGLLYTEMING
                     KALCYDDENTKKMLKIEEEEHPVAVQIFGSEPEFMGRATEIMNDYSNEILDINMGCPA
                     PKVVKNGDGSALMKNPKLAEEVLRAVVKNSKKPVTLKIRKGWDDNSVNAVEIAKIAED
                     CGISALAIHGRTREQFYTGKADWDIIAEIKKNLSIPVIGNGDVFTIEDSINMLDKTGC
                     DAIMIGRGAQGNPWIFKRINHYMNTGEILPEPTLNEKISTAIKHLKLAVEEHGEYVAV
                     REMRKHIAWYLKGLRNSAKLRDEINKIEDYQEVVSKLEYYMEDSLT"
     gene            complement(3870..4640)
                     /locus_tag="KNP36_000005"
     CDS             complement(3870..4640)
                     /locus_tag="KNP36_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III pantothenate kinase"
                     /protein_id="HBF0871909.1"
                     /translation="MLLVFDVGNTNMVLGIYKGDKLVNYWRIKTDREKTSDEYGILIS
                     NLFDYDNVNISDIDDVIISSVVPNVMHSLENFCIKYCKKQPLIVGPGIKTGLNIKYDN
                     PKQVGADRIVNAVAGIEKYGAPSILVDFGTATTFCAISEKGEYLGGTIAPGIKISSEA
                     LFQSASKLPRVELAKPGMTICKSTVSAMQSGIIYGYVGLVDKIISMMKKELNCDDVKV
                     IATGGLAKLIASETKSIDYVDGFLTLEGLRIIYEKNQE"
     gene            complement(4659..5249)
                     /locus_tag="KNP36_000006"
     CDS             complement(4659..5249)
                     /locus_tag="KNP36_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBF0871910.1"
                     /translation="MMNTSASVRKVNVRKMTIIGVLSAISIMLSMTPLGFIPVGPTKA
                     TIMHIPVIIGAIMEGPIVGAAIGFIFGISSLLNAITNPTATSFVFINPLVSILPRVMI
                     GVLAYYVYQLIIKATNKVYISGLITGAIGSLLNTAGVLGMIYVLYADKYLHAMGKSGS
                     AGKVIMALAAANGVPEAIVGALVVAAVATVLKKSKK"
     gene            complement(5432..6400)
                     /locus_tag="KNP36_000007"
     CDS             complement(5432..6400)
                     /locus_tag="KNP36_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="P1 family peptidase"
                     /protein_id="HBF0871911.1"
                     /translation="MYNNILDIEGLKVGQVEDRNGLTGCTVVICEEGATCGVDVRGSA
                     PGTRETDLLDPVNMVQKVHAVVLAGGSAYGLESTCGVSRYLEEKGIGFDVGVGKVPIV
                     VGAVLFDLGVGSFKCRPDLKMGYRACEVANTDILNQGNYGAGCGATVGKIRGQEYAMK
                     GGIGSYSIKLDNGLIVSALIAVNALGDVYENGKVIAGALNDKKTETIDTYKLMKQGES
                     KGGFSVDNTTIGIIATNAKLTKAGCKKISQMGHDGYAKSIFPIHTPHDGDTIFTISTG
                     EIEADITLVGSLAVEVVEKSIINAVKKADSVENIMAYKDIVKKREI"
     gene            complement(6393..7370)
                     /locus_tag="KNP36_000008"
     CDS             complement(6393..7370)
                     /locus_tag="KNP36_000008"
                     /EC_number="6.3.4.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin--[acetyl-CoA-carboxylase] ligase"
                     /protein_id="HBF0871912.1"
                     /translation="MRDKIIEIILNNKSEFISGEELSKQLGVSRAAIWKHMKALKEEG
                     YNIESVNKKGYRLAENPTDLLSPQNIYYKLDTEFIGKNIEHLDTIDSTNEHAKRIAIN
                     SVDGTVILSEHQDMGKGRLGRRWDSKPHEGIWMSIILKPDMEPFKAPFITLIAGASVT
                     KALNNLGANTLIKWPNDVILNGKKICGILTELSAEIERTNYVVLGIGINVKIMDFEQE
                     IADKATSLYKEGYMLSRVDIVRNVLTEFEKLYLDYTVNNSKEKTLKICRDYSAIIDKN
                     IYVLKGDNRELVKCLDINEEGNLLVQRSDGSIKEIISGEVSIRGEKGYV"
     gene            complement(7685..9655)
                     /gene="ftsH"
                     /locus_tag="KNP36_000009"
     CDS             complement(7685..9655)
                     /gene="ftsH"
                     /locus_tag="KNP36_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HBF0871913.1"
                     /translation="MNKLLKGAGFYLLVFIIIVGIVQFSGKPTEKIKDLKFSEVYREL
                     TDENISRLYFVNQTSVEGTIKDTNTKFKSYVPTEVMGNKLADEVLDQAKAGKLTFGGE
                     AKPSTPWFVEMLPTLLLIFFMVIIWFVFMNQSQGGGGKVMSFGKSKAKVHKDDEKTRV
                     TFKDVAGLDEEKEDLQEVVDFLKNPKKYIELGARIPKGMLMVGPPGTGKTYLSRAVAG
                     EAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKSAPAIIFIDEIDAVGRKRGAGLG
                     GGHDEREQTLNQLLVEMDGFGVNQGIIIMAATNRPDILDPALLRPGRFDRQVVVGTPD
                     VKGREAIFKVHSRNKPLSDDVKMDVLARRTPGFTPADIENLMNEAAILTARKREKKIK
                     METIEEAITKVIAGVAKKSKVISEKERRLTAYHEGGHAVCAHVLEEVSPVHQVTIVPR
                     GRAGGFTMQLPVEDKFYATKNEMKENIIVLLGGRVAEELVLKDVSTGASNDLERVTAT
                     ARSMVTKYGMSSKLGPMSFDSDDEVFLGNSFSSKRNYSEEVAFEIDQETKRIVDGAYD
                     KTRSILQENMDRLEYVAQALLIYETLDAEQFVKAFNKELPLNEIENAVTEENSSKEVE
                     EQLTIKLEKDEEERNNVIDINKNLEDKSDKDK"
     gene            complement(9689..11077)
                     /gene="tilS"
                     /locus_tag="KNP36_000010"
     CDS             complement(9689..11077)
                     /gene="tilS"
                     /locus_tag="KNP36_000010"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HBF0871914.1"
                     /translation="MIFDKVLSTINKHNLIQKGDKIVLGLSGGPDSVCLLHVLNRLKK
                     DFNIEIYAAHLNHQIRGIEAQKDALYVSKLCEDMGIIFFVKSINVPKYCENEGLSLEE
                     GARKLRYEMFYEIKDKIKANKIAIGHNLNDQAETVMMRIMRGTGLKGLKGIDYIRDNC
                     IIRPILDVERNEIEEYCEAYNLNPRIDKTNLENIYTRNKIRLDLLPYMKDNFNSNVIE
                     SIVRMSNSLKSDNDYIEKEAEAKFREVSNIKEKGFVEINLDDFVCLHDAIKVRVLRNS
                     IKHILGDTNFVDQRHIEDIMSLEDNSKVNKMLTLPRNIFVYRKKDSIILTNEEIVNEE
                     IEFYYNVPSNGFIKIKELKQIIETQVMSIDRYKSMKLDNSSKGFDFNKVKGGIVIRSR
                     RQGDKIKLAMGSKKVKDLFIDLKIPREERCKIPIITDGEGIICVGDYKISENYKIDES
                     TKEVLKINFNKL"
     gene            complement(11260..11688)
                     /locus_tag="KNP36_000011"
     CDS             complement(11260..11688)
                     /locus_tag="KNP36_000011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HBF0871915.1"
                     /translation="MEEKSLSVKISINTRQYDEKGNMDTIEMTAFGKIFYKNDGIYVI
                     YKEKEEDIEITNTIKILKNQVSIKKFGAINSTMLFKCGESSTTKYVTPQGTLLIDIDT
                     RELDINIQEGEHIKLKIDYNIKVQDLFLGRNKIDIYIGTK"
     gene            complement(11705..12511)
                     /locus_tag="KNP36_000012"
     CDS             complement(11705..12511)
                     /locus_tag="KNP36_000012"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HBF0871916.1"
                     /translation="MNNKPIGVFDSGLGGLTVLKEIMKILPNEDIIYFGDTARIPYGS
                     RSKETIIKYTFQAINFLKTKGVKAIVIACNTATARSLKEAQEKYDIPIIGVIEAGART
                     AVSSTKNKIVGIIGTEGTISSKAYNLEISKIDESIEIVNKACPLFVPIVEEGWANTEV
                     AKLTAKIYLQELKEKNIDSLVLGCTHYPILKRTIGEEVGEHIKLVNPAKETAKDLKKI
                     LEVQNIINNTEIHGTYQYYVSDIPEKFSDIAREFLKKKIDKIQKVEIQKY"
     gene            complement(12713..13198)
                     /locus_tag="KNP36_000013"
     CDS             complement(12713..13198)
                     /locus_tag="KNP36_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase"
                     /protein_id="HBF0871917.1"
                     /translation="MATLLALTFIFMPIKEVFAYEPTENIKKVNKQEKNIAKKEVINL
                     SDNDLMLLSKLVAGEARGESYEGQVAVAAVVINRVLDPRFPDTIEEVIYQKNAFSVVL
                     DGSIKMAPTDSARKAAQEALYGTDPTNKAVYFWNPEIATCKWINRLNPYMRIGNHVFA
                     K"
     gene            complement(13249..13908)
                     /gene="spoIIR"
                     /locus_tag="KNP36_000014"
     CDS             complement(13249..13908)
                     /gene="spoIIR"
                     /locus_tag="KNP36_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein R"
                     /protein_id="HBF0871918.1"
                     /translation="MRKIKIRLGLLILSLISVISIMTIVINGEVKKVDNISKDYKDKL
                     IRFHVIANSNTDEDQELKLKVRDEVIKYLQPKLQNSKSIKESEAIIKKEYSSLEEISK
                     NIILKNGYNYSVKVGIQYSNFPTKQYSNIVLPAGEYKALKIIIGKGEGKNWWCVMFPP
                     LCFVDESNGVIDKSTDDKLKEVLTDKEYKLIKQDTPKKTSRVKIKFKVLEVVKDLEKK
                     F"
     gene            complement(14053..14733)
                     /locus_tag="KNP36_000015"
     CDS             complement(14053..14733)
                     /locus_tag="KNP36_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0871919.1"
                     /translation="MENLTKLNLDNYKPLRDVVFENLREAILEGKLKPGQRLMEVQLA
                     EQLGVSRTPVREAIRKLELEGLVVMLPRKGAYVANMSLKDIMDVLEVRASLEGLAAYL
                     AAERISDEDIKKLKDISEEFKKSTLESDVDALLKLDVEFHECIFKATNNKKLIQLINS
                     LWEQVYRFRVTYMSAYDTSHNIVEEHKYLLDAIIKGDSELSKKYATEHIEKAEQFMID
                     KAMISKDL"
     gene            complement(14717..15607)
                     /locus_tag="KNP36_000016"
     CDS             complement(14717..15607)
                     /locus_tag="KNP36_000016"
                     /EC_number="2.7.1.148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-(cytidine
                     5'-diphospho)-2-C-methyl-D-erythritol kinase"
                     /protein_id="HBF0871920.1"
                     /translation="MDFIRLKSRAKINLSIDVLGKRQDGYHFVEMIMQTIDLYDIVKI
                     KELDEDEIKVKSTSLDIPLDEDNIVYKAAKILKNKFYIKKGVEIFIEKNIPVAAGMAG
                     GSSNAAAVLVGLNHLWELRLSEDELKEIGLNLGADVPFCISGRPALAQGIGEKLTNIK
                     GLPCDTNILICKPDLFVSTKEVYQGLDLNNIKKRPNNKYLIECLKSEDIKAVSESMVN
                     ILENVTIGKHKEISDIKQVMMKNNALGSMMSGSGPTVFGLFKNKEDALIGKKELLKKY
                     KQVYVVNSSQKGVEICGEFN"
     gene            complement(15725..17275)
                     /locus_tag="KNP36_000017"
     CDS             complement(15725..17275)
                     /locus_tag="KNP36_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3794 domain-containing protein"
                     /protein_id="HBF0871921.1"
                     /translation="MELIKDVIKVDNRIDFGKFQTFIEAEAVVPDKKLDVYEIVKTEG
                     YISLKKIEMADGKILCRGSFNYNVIYIADDKNTISNVDGKVDINEVIEKDNVIQDMEY
                     MLFSEVEHMDCTIMNERKIKVGALMNIRGSLFEKQRLDIVKDVAQVECIQKHRKEICF
                     QDIVGIEKAESSIRDTITINTEEIQSIISLNPCVKVKESRVTDNKVIIGGVLEINPLA
                     CTYEGELVELDRVGIEFTQFVEVPGVSDGMTEEVLLSMSDFNHIFKQNSESNTGLLEI
                     DCMACCKVKVTDEVTREVLQDAYSPQKIIKFDHKPIQLNKTLRRSEETFMVREGIRND
                     NDDIQIKDIVSVCPTMSIENSYIEGNKSIIQGIIKVEILFVPVEGLKLVYKISEEIPF
                     EHDIEMDNLTDTASVFNTACIDKVEVDLNRDQIDLIIKIKRFTEALDKKAENFIIKGE
                     DQGVYDLSKAPSIIVYICKEGDTFWNIAKKYNTTENEIAELNDIKLDEPIKPGKCLIL
                     EKKVVLVD"
     gene            complement(17369..17635)
                     /locus_tag="KNP36_000018"
     CDS             complement(17369..17635)
                     /locus_tag="KNP36_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Veg family protein"
                     /protein_id="HBF0871922.1"
                     /translation="MATVQTLDKIRVSLERHIGKKILLKANKGRKQIITKEGILEKVY
                     PSVFVIKLDDESNGYPRVSYSYSDLLTSNVKLQVFRDQDKLQIS"
     gene            complement(17783..18643)
                     /gene="yabG"
                     /locus_tag="KNP36_000019"
     CDS             complement(17783..18643)
                     /gene="yabG"
                     /locus_tag="KNP36_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation peptidase YabG"
                     /protein_id="HBF0871923.1"
                     /translation="MKVGDIVARKSHNKDIVFKIVSFGVDENNEKIAILKGIAFRVIA
                     DAYIDDLELVKAPDIKDILIDKNVENLLYKSVRKAKERQKRMTRAVPKLQLNPNTYGM
                     PGKVLQIDGDKEYLKICLDVYAQLGIPAVGVAVSEQNQYKEVRALLEKYNPDILVITG
                     HDAMTIKRGDIEDMSNYRNSSNFVKTVKEARKWQPNLDNLVIFAGACQSNYEKIISAG
                     ANYASSPGRIMIHALDPVFIVEKIACSRIDVVVPIDEVIEQTITGVKGIGGSETRGKF
                     RWAMPKTILH"
     gene            complement(18727..19665)
                     /locus_tag="KNP36_000020"
     CDS             complement(18727..19665)
                     /locus_tag="KNP36_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HBF0871924.1"
                     /translation="MKFLDLHCDTIAKLMENVETSELKSNKYSVDIDRLKKGDSLAQT
                     FALFVDTEEVKHPFDYCMSMANKFHEEMKKNSDEIALATNYEEIMKNQSEGKLTALLS
                     IEEGAVLEGKLENLKKFYDLGVRMMTISWNHVNELSFPHNKVEYREKGLTDFGREVVH
                     KMNELGMLVDVSHISDGGFYEIAKISSKPIIATHSNSRAMMNHSRNLTDDMIKVLANK
                     GGVTGINFFHLFLSDKSESKLEDMVRHIKHIVNVGGIDVVSLGSDFDGIDSKVEIEDI
                     SQMGKLYEPLKKEGFSEDDIEKIYYKNALRVIKEVL"
     gene            complement(19775..19936)
                     /locus_tag="KNP36_000021"
     CDS             complement(19775..19936)
                     /locus_tag="KNP36_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871925.1"
                     /translation="MFILRFADDDDNLSVKDFTSLTDLKKYISENNIDKTWHQIEEVK
                     KVIPNLKEE"
     gene            complement(19946..20443)
                     /locus_tag="KNP36_000022"
     CDS             complement(19946..20443)
                     /locus_tag="KNP36_000022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC-C domain-containing protein"
                     /protein_id="HBF0871926.1"
                     /translation="MSLYTEWRNLSDNHESQEAEVKFWEEYLKVEAGIYNEILNNKMD
                     VVEGKVSELAEKFGTTNEFFMGFIDGISESLKEDIVLEEVEADKEVSIKIDWEKLYNN
                     MVTVEAHWLYNLQGWEDILPADQRKEIIKAYKKSKTIVKEAKIGRNDSCPCGSGKKYK
                     KCCGK"
     gene            complement(20558..21268)
                     /locus_tag="KNP36_000023"
     CDS             complement(20558..21268)
                     /locus_tag="KNP36_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0489 family protein"
                     /protein_id="HBF0871927.1"
                     /translation="MENYEYSGFYIEKPVGNNVFSYDKRENKSIYVPKLINGTLNDVR
                     LGNEVVFNEVDENKEIKAKGLENMVEYVLGNKKIYVFDNHNHAFYFWAKSLLKGEFTK
                     GCKLVHVDQHKDTREPENYDVDVNNLKDVFRYTNEVLNVGSFIKPALKYNIFSELIII
                     DSLYGFDLEVESEFVLDIDLDIFSSDMDYIPFELKFYKIKNLIKKAKVITIATSPYFI
                     NQEYAIKVLKELFNYDII"
     gene            complement(21444..21974)
                     /locus_tag="KNP36_000024"
     CDS             complement(21444..21974)
                     /locus_tag="KNP36_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871928.1"
                     /translation="MDIRALPIRITKEEAIEIAKSGKNSLFSKLILKNKYAHEVRLHY
                     IEFKIITLKIHKTKSIFKNRRYSNDINELKILVNGSTGSGSIVQDFPTYEVVKNVDCN
                     IVQYSDKDERRVKAKANKMAMRLTHRFMGGIPEIEIVKIESIFRPYWVVFFGKVELNR
                     RVSYLPIEADGFVIGM"
     gene            complement(21991..22221)
                     /locus_tag="KNP36_000025"
     CDS             complement(21991..22221)
                     /locus_tag="KNP36_000025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871929.1"
                     /translation="MSKLVSKVKKDLEIKWLGIDGFLVLLYFLITGFIFYGILTRNDI
                     IVGKIIPYGVMAVVIVIFFDYIYRVLKMTRKK"
     gene            complement(22236..23630)
                     /locus_tag="KNP36_000026"
     CDS             complement(22236..23630)
                     /locus_tag="KNP36_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter family protein"
                     /protein_id="HBF0871930.1"
                     /translation="MLTFWENGIIVIFAFILLGIGYYFSRNVKDMESYYLGNRSLPWS
                     LIVGTLVASWYGGVGTVGSVEYAAIYGISAWAVWSIAAHIGRMPLALWVGPRIHIRTN
                     ITVPDLLESFYGKHVAIIGAILMFIYCAQLGEITAMGTIGNVAWKIDKELIGLIMVGV
                     VVVLTVLGGLMGVAITDMVLFFCMVFGLTMVMPGQFEQIGGFQGLTEALKDAPQLMHP
                     TKGMSAMKALMLIVYSFGAYSDPTFYQRFSAADSPKVGRRALLTCFSLWICFDMVLTM
                     TGLIVRATYPEMAPAAGYITLVLDTLPQGIRVIFIIGILGSIISTLDSYYLAAGATLA
                     NDIYGRITKKELSQKQLVKFTRIGVCLAAVMGLSVAFRFENVYDACIFVGSIWMGSAF
                     VPIVGGLLGNGRRTSMGGILGMIVGGVTFGYFKIFPVQSFELEPLVIAIPFSFIAWMI
                     GNRIGENLNTQNNL"
     gene            complement(23756..25009)
                     /locus_tag="KNP36_000027"
     CDS             complement(23756..25009)
                     /locus_tag="KNP36_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0871931.1"
                     /translation="MESKNNVKRFLIIFILAFGTTAMYSLPYMKSSFYDPMQQALALS
                     HTQIGNLLSLYGLVGMVSYFIGGWFADRFSVRKLITFSLIASGILGFYFSTFPSYSMI
                     LLIFVLWGFTTILTFFSASVKVVRMQGSESEQGRIFGFYEGLSGVSGTLISFIGLYFF
                     GKFAEITVGFKYVVWLYSAASIICGILLFFLVEEKKDSGASDEGLSIKSLLKVVTIPK
                     AWLIGLIIFSTYLVFSSLTYLSPYLSEVYVMPMTLVSALSIIRTYVIKMGASPVAGVI
                     TDKVGSSIRVMFVGFILMTVSTAAYLVIPKSTGFIWIAVINMIILSVILFGFRGIYFA
                     SVSESNISLETTGAVVGFASFIGFSPDAFYYTIAGNWLDKYGQTGYTYIFILSVVCAV
                     IGIFATYALNKINKRENKGLNNKIA"
     gene            complement(25060..26214)
                     /locus_tag="KNP36_000028"
     CDS             complement(25060..26214)
                     /locus_tag="KNP36_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBF0871932.1"
                     /translation="MSNNINQDLETKIIHWGHSADPTTGALATPICQTATFAAKTVEH
                     FEELCMTWGYVYTRECNPTLTELEAKLAMLENAESAISSTSGMGAITSTILALVKSGD
                     HIVSSDGIFSHTKLFMSELLSKFGVEVTFVDAVNPQNVKEAMRPNTKIVYIESPLNPS
                     LDLVDIKTIAEIAHENKSLAIVDSTFGTPIVQRPIDLGADLVIHSLTKFINGHGDTLG
                     GAVAGSKELIDLVRWPSLCCFTGASLPPMSAWMILRGMKTLDMRMKKHCENGLAVAEF
                     LEEEENVELVKYPALKSHPQYELCKTQMNGLGGGVVSFKLKDGISGLTRDQASRRLMN
                     SLELATIATSLGEEHTLVQMNGENLIRIAVGLESSNDIINDFKQAIEKLK"
     gene            complement(26774..27342)
                     /locus_tag="KNP36_000029"
                     /pseudo
     CDS             complement(26774..27342)
                     /locus_tag="KNP36_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426023.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
     gene            27545..27772
                     /locus_tag="KNP36_000030"
     CDS             27545..27772
                     /locus_tag="KNP36_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBF0871933.1"
                     /translation="MNSLLKEAIDELKNIHCGEVFLLKELFKGYEWNRLEMNIRLKLG
                     KLFLYEVVTNPNLNVEVINKNSAYQQMYKKK"
     gene            complement(27991..28734)
                     /locus_tag="KNP36_000031"
     CDS             complement(27991..28734)
                     /locus_tag="KNP36_000031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBF0871934.1"
                     /translation="MENYQSTNTCTYNILYVQFNEDFERSKYFSYDVKYPVIYNIRNQ
                     STYVNPVILNNINNAVRMTVNNFKNGLQEEEREYNNAASQNSLPKQSYWVSTSYAVTF
                     NKNYVLSMILNLMGFANNYGPKYNTLNNYNIDLTTGKELLLNDIFRDGVDYINIITDY
                     IKSQINENREMYYSNVELVIPEDQAFYLTDNGIIIYFGVDEIAPESFGIPKFELKFSD
                     FGNFINLRFYCISPDIYVQSRGRAKHFMG"
     gene            28902..29774
                     /locus_tag="KNP36_000032"
     CDS             28902..29774
                     /locus_tag="KNP36_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBF0871935.1"
                     /translation="MLLLADKWKDYELIDMGNGEKLERWGSYVLRRPDPQVVWPMESE
                     WALWKNPHGHYHRSNKGGGQWEHKKRYPEQWTINYKNLKFHIKPTGFKHTGLFPEQAA
                     NWDWMIEKIKKANRPIKVLNLFAYTGGATVACASAGAEVCHVDAAKGMVNWAKENIEL
                     SGLKNQTVRFIVDDVVKFVEREIRRGKKYDAIIMDPPSYGRGPKGEVWQIEEKLYSFV
                     DLCMGVLSDNPLFFLINSYTTGFSPIVLENVLSTTIGKKTNTGDIYGGELGIPASRDG
                     KILPCGIFGRWEKK"
     gene            29774..30439
                     /locus_tag="KNP36_000033"
     CDS             29774..30439
                     /locus_tag="KNP36_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBF0871936.1"
                     /translation="MIKVIYEDNHLLVVEKPVNILSQGDNTNDKDMVNLLKDYIKKKY
                     NKPGNVYIGLIHRLDRPVGGVMVFAKTSKAASRLSEQVRSKTFKKTYLAVVHGKIKSN
                     SDILKDFLYKNKKTNMVTVVKKSHKDAKEAELNYNVLDFKENLSLVQVNLKTGRSHQI
                     RVQFASRKHPLYGDQRYGKEINKIGQQISLWSNKIEICHPTTKEKMEFTCHPPDKYPW
                     NIF"
     gene            30460..31317
                     /locus_tag="KNP36_000034"
     CDS             30460..31317
                     /locus_tag="KNP36_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0871937.1"
                     /translation="MSKKFSIGEMSKLHKISIQTLRYYDQIDLFKPVHVDQESNYRYY
                     SIDQFSQLDIIKYLKYLGMPLKEIKSKLDENNEEILKLLTNKINIVDEKIKELELIKK
                     VLSTKKETMEKGMKVDEVGKIVRKHIPRRSILSIEYEEGLSSEETMELSRRQIANILE
                     DNISVFYGGVSGLVSIDKFLKEDKVIYDNSFVTVERDLFDIKSQKHITEISSGDFICM
                     TYKGPYKENYTAFKKLVDYVEYKRIPIENYIYEIPIIDPLSTNNEEELLTEIQIQVKK
                     REIDLRCLV"
     gene            complement(31473..34019)
                     /locus_tag="KNP36_000035"
     CDS             complement(31473..34019)
                     /locus_tag="KNP36_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0871938.1"
                     /translation="MNIFNKVALQGLKKNRTRTLVTIIGVVLSAAMITAVTTFGVSLM
                     NYMINGAIIKYGDWHVQFLDVDSSFVQEQRVNDEVANTATFENIGYATLEGNRNPDKP
                     YLFIAGFSKEAFDTLPITLISGRLPENSREILVSSKVATDGGVKFAVGDTISLDVGKR
                     MSENEKLGQSDPYTAGSEVFVPQDKKTYTVVGICRKPVFEESSAPGYTLITKEDKQVK
                     TDSLSLFVTLKNPHQIRSYTSSTKDHASIFNDNVLRFIGVSDNNLFNMFLYSVGGIVL
                     AIIMLGSIFLIYNSFNMSLNERTHQFGILSSVGATAKQLRNSVLFEGICIGAIGIPIG
                     VAIGIVSIGLVISVISKNFANILYVNVPLTLTLSIPAIIVAAVVSMVTILISAYIPAR
                     KAANTPVMECIRQTNEVKIESKSVKTSKLTQRVYGLEGVLAMKNFKRNKKRYRSIVLS
                     LVLSIVLFISTSALVADLKQMSNQRSEVTDQDIIFSTQGMKDNEMLKLYDKLKTANGV
                     YEGLYQKLMTYSCVAKVSELTDDYLNYEGSHSMSEMLELPVDMQFLDDRTYLNIIKSL
                     GLPAEEYTGQNAKLIAVSMVTKDNNIIDIFNSSSMNVSLTPETNGKLEIPERQNVNIS
                     FVKVVPPDSPPGIRSSDVKKASFRVLAPYSAKDKFEIPGVSTGIESLSFQSKNPTQSV
                     AEMEQIIESEGVTNEYNLYNMYGMMDENRNYIFIANVFAYTFIIMISLISIANVFNTI
                     STNIKLRRRELAMLRSVGMSEHDFQKMMNFECAFYGMRALFFGLPIAVISSWLIHKVM
                     VTDDIDFVIPWFSIGISIFSVLFIVFITMLYTINKIKKENIIDALRDDMA"
     gene            complement(34019..34705)
                     /locus_tag="KNP36_000036"
     CDS             complement(34019..34705)
                     /locus_tag="KNP36_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0871939.1"
                     /translation="MAFLKIEDLCKVYGKNENKVTALDHVSLTIEKGEFTAIIGSSGS
                     GKSTLLHSIAGVDVPTSGKIYLEGQDVYGQSNEKLAIFRRRQVGLIYQFHNLIPTLNV
                     VENITLPILMDKRKVNQERLNDLLELLGLKERKTHLPNQLSGGQQQRVAIGRALMNAP
                     AVMLADEPTGSLDSKNGQEIIQLLKESHSKYHQTLIIVTHDENIALQADRIICISDGK
                     VVRDERKVNR"
     gene            complement(34788..35777)
                     /locus_tag="KNP36_000037"
     CDS             complement(34788..35777)
                     /locus_tag="KNP36_000037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0871940.1"
                     /translation="MFRNREFRKFAILFLLITILTVALGFAISIMTGILSIVSATTFG
                     IAFFVFTKNRYKSIAQISEQINLVLHNANHLYIAESDEGELSILQSEITKMTLRIREQ
                     NYALKKEKEHLADSLADIAHQLRTPLTSVTLILSLLENTSDEDERKELIRETEELLIR
                     MDWLITSLLKLSRLDAGIVVFQKEQIDVNNLISSALHQLLIPMELHNITLHIDIPKGV
                     RILGDLNWLSEAIQNIFKNCMESVGDNGKIDIICEDNFLFTQLTIHDNGAGFKKEDLP
                     CLFNRFYRGKNSSTAGYGIGLALCKTIIMRQGGTITAQNHPQGGAIFVIRFPK"
     gene            complement(35764..36450)
                     /locus_tag="KNP36_000038"
     CDS             complement(35764..36450)
                     /locus_tag="KNP36_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0871941.1"
                     /translation="MKRIFLVEDDKAIAKNLILLLNSEGFIVTHVSTRSEALVEIAKN
                     KFDLALIDISLPDGNGFTICTEIKEKQDIPVIFLTASGDESSVVTGLNMGADDYITKP
                     FRPRELIARIRTALRKSGRFGSTFEICGLYVDTATGVVKKNGNEVFLSALEYRLLLVF
                     ISNPKSIITRVRLLDELWDAAGEFVNDNTLTVYIKRLREKIEDDPSSPQIILTVRGTG
                     YRLGGSYVSK"
     gene            complement(36950..40156)
                     /gene="carB"
                     /locus_tag="KNP36_000039"
     CDS             complement(36950..40156)
                     /gene="carB"
                     /locus_tag="KNP36_000039"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HBF0871942.1"
                     /translation="MPKLDSIKKTLVLGSGPIIIGQAAEFDYSGTQACQALKEEGIEV
                     VLVNSNPATIMTDKEIADKIYIEPLTIEFIEKIIEKERPDSLLAGMGGQTGLNLAVEL
                     HDAGILDKYNVKVIGTSIESIKKGEDRDLFREVMKEINQPVIVSDIVTNLEAGLEFAN
                     KIGYPVVVRPAYTLGGTGGGIADTEEELREILSHGLQLSPVGQVLLEKSIKGWKEIEY
                     EVMRDGNGNCITVCNMENVDPVGVHTGDSIVVAPSQTLSDEEYQLLRKASIDIINAIE
                     VQGGCNVQIALNPHSLEYAIIEINPRVSRSSALASKATGYPIAKVAAKIALGYTLDEI
                     ENAVTKKTYACFEPTLDYVVVKIPKWPFDKFRHANRKLGTKMMATGEIMSIGSNFEAA
                     ILKGIRSLETGKYSLVHAPSEGRTLEELKARVVVPDDERLFDLAEMIRRGYKVEMISE
                     ITGVDKWFINKFKWIVEQEEKLKVLKIEDLDKEYLHELKKKGFSDKGISDLMKISPEK
                     LYELRSLYNIQPVYKMVDTCGGEFEALSPYYYSTYEQYDEVVVSDKRKVVVLGSGPIR
                     IGQGIEFDYCSVHCVKSLRKMGIETIIVNNNPETVSTDFDTSDKLYFEPLTEEEVLNI
                     IEKEKPEGVILQFGGQTAIKLAKFLHEKNIPILGTDFRDIDAAEDREKFDDLLERLDI
                     NRPKGKGVWTTNEGVEIAKELGYPVLVRPSYVLGGQGMEITYNEEKLIQYLDDAFDRD
                     HKNPVLIDKYLTGREIEVDAICDKEDILIPGIMEHLERAGVHSGDSTTMYPSQNISDE
                     IKEKIVEYTKKIALDLNVLGMVNIQFIEFQNELYIIEVNPRASRTVPYISKVSGVPIV
                     DLATKCMLGAKLKDLGYGTGVYKEPKLVSVKVPVFSMSKLSKVEVSLGPEMKSTGEVL
                     GVGENLEEALYKGFLAAGRHMSDERGVVLATVNNHDKDEFIEIAKDMKELGYTFVATE
                     GTAKSLRENGIEADIVNRIEEPRPNILDAIRNKQVDIVINTPTKGNDSTRDGFKMRRT
                     AIEFSTEIMTSLDTLKALVEVKKKHLNKDKLKVYNIAE"
     gene            complement(40349..41398)
                     /gene="carA"
                     /locus_tag="KNP36_000040"
     CDS             complement(40349..41398)
                     /gene="carA"
                     /locus_tag="KNP36_000040"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002845470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HBF0871943.1"
                     /translation="MKARLILEDGTVFIGKAFGYLEESVGEVVFNTSMIGYGEVLTDP
                     SYYGQIVTMTYPLVGNYGINLSSAESEKVQVKGFIVREKSDSPSNFRCEIDIDQYLKQ
                     NKVIGLEGIDTRALTKILRNNGTMKGIITLEDSKLEDVKHKLDKFSNTEAVRTVTRKE
                     VEHIKGNGPKVAVMDFGVKRNILRSFIARGCDITIFPATTSPEDVLSINPDLIFLSNG
                     PGDPEDLEDVIENIKALIGKKPIVGICLGHQLLALALGGKTAKLKFGHRGGNHPVKDL
                     EEGKVFITSQNHGYYVSEVPEQMKVTHINLNDNTVEGMRHEKLDVYSVQYHPEACPGP
                     KDNDYIFDKFLELVK"
     gene            complement(41655..44861)
                     /gene="carB"
                     /locus_tag="KNP36_000041"
     CDS             complement(41655..44861)
                     /gene="carB"
                     /locus_tag="KNP36_000041"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HBF0871944.1"
                     /translation="MPKLDSIKKTLVLGSGPIIIGQAAEFDYSGTQACQSLKEEGIEV
                     VLINSNPATIMTDKEVADKIYIEPLTIEFIEKIIEKERPDSLLAGMGGQTGLNLAVEL
                     YEKGILDKYGVKIIGTSVESIKKGEDRDIFREVMKEINQPVIVSDIVTDLQAGLDYAL
                     TIGYPVVVRPAYTLGGTGGGIADNEEELREILSHGLQLSPVGQVLIEKSIKGWKEIEY
                     EVIRDSKGNCIVVCNMENIDPVGVHTGDSIVVAPTQTLSNKECAMLKKASLDILNAVE
                     VQGGCNVQFALNPHSFEYAVIEINPRVSRSSALASKATGYPIAKVSSKIALGYTLDEI
                     ENAVTKKTYACFEPTIDYVVAKIPKWPFDKFKKANRKLGTKMMATGEIMSIGSNFEAA
                     ILKGIRSLETGKYSLVHTPSEERSIEELKKRVVVPDDERLFDLAEMIRRGYKVEMIEQ
                     ITGIDKWFINKFKWIVEQEEKLKVMKIEDLTKDYLLELKKKGFSDKGISDLMKISPEK
                     LYELRSLYNIKPAYKMVDTCAGEIDAISPYYYSTYEQYDEVVVSDKKKVIVLGSGPIR
                     IGQGIEFDYCSVHCVKSLRKMDIETIIINNNPETVSTDFDTSDKLYFEPLTEEEVLSI
                     IEKEKPEGVILQFGGQTAIKLAKFLHEKNIPILGTDFDDIDAAEDREKFDDLLERLDI
                     NRPKGKGVWSLNEGIEVANELGYPVLVRPSYVLGGQGMEITYNEEKLSQYLQDAFDRD
                     HKNPVLIDKYLTGREIEVDAICDKEDILIPGIMEHLERAGVHSGDSTTMYPSQNISDE
                     IKEKIVEYTKKIALDLNVLGMVNIQFIEFQNELYIIEVNPRASRTVPYISKVSGVPIV
                     DLATKCMLGAKLKDLGYGTGVYKEPKLVSVKVPVFSMSKLSKVEVSLGPEMKSTGEVL
                     GVGENLEEALYKGFLAAGRHMSDERGVVLATVNNHDKDEFIEIAKDMKELGYTFVATE
                     GTANSLRENGIEADIVNRVEESRPNILDAIRNKQVDIVINTPTKGNDSTRDGFKIRRT
                     AIEFSTEIMTSLDTLKALVEVKKKHLNKDELKVYNIAE"
     gene            complement(44914..45957)
                     /gene="carA"
                     /locus_tag="KNP36_000042"
     CDS             complement(44914..45957)
                     /gene="carA"
                     /locus_tag="KNP36_000042"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HBF0871945.1"
                     /translation="MKGKLILEDGTVFEGKAFGYLKEAIGEVVFNTSMAGYGELLTDA
                     TYYGQIVTMTYPLIGNYGINLEDVESNKVQVKGLIVREKSDNPNNFRCEMDIDTYLKQ
                     NKVIGLEGIDTRALTKIIRNNGTKRGIITLENVSLQDVQSKLEEHCNKDSVKNVTRKE
                     IENIKGTGAKVVVIDFGVKNSVLESLKACNCDITIVPAMTTVEEILNINPDLILLSNG
                     PGNPEDINDIVENIKKLIGKKPLTGIGLGHQILALALGGKTSKLVFGHRGGNHPVKCL
                     ETGKVFITSQNHGYNVSEMPENTEVTHINLNDNTIEGMRHKELPIYSVQYIPEYTTKE
                     DLDCIFNKFLALI"
     gene            complement(45983..46699)
                     /gene="pyrF"
                     /locus_tag="KNP36_000043"
     CDS             complement(45983..46699)
                     /gene="pyrF"
                     /locus_tag="KNP36_000043"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HBF0871946.1"
                     /translation="MINGKEKLIVAIDTDEFDKAKELIDRLEDSVDIFKVGLEQYVAT
                     KGKTIDYLKEKGKKIFLDLKFHDIPNTMKSAVKAAVRDNVWLMTIHVSDMEGMRQCAL
                     IAREEAERLNIEKPLVVGVTVLTSLSNQDLQDIGCNMTTEELAIKRAKLAKESGIDGV
                     VCSAQEVDKIVEACGTDFITVCPGIRPKSAEVGDQKRVVTPSDAIKKGAHYLVVGRPI
                     TKAENPRESAINIVREIENA"
     gene            complement(47075..47710)
                     /locus_tag="KNP36_000044"
     CDS             complement(47075..47710)
                     /locus_tag="KNP36_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1847 domain-containing protein"
                     /protein_id="HBF0871947.1"
                     /translation="MYKCGKCNLRGCSNGNMDKLMKICPTREIELQQKAKQLYEEEEN
                     RKIAYNAGLVEAEGYCQYTRLKEIIEFAKKCGYKKIGIAFCIGLKREMQTVQKIFEHH
                     GFEVFSVICKNGAMPKSTIGLEASQTISKCSDEVMCNPIGQALFLNEAKVDLNVILGL
                     CVGHDTLAMKYMEAPITTLVVKDRVTGHNPVAAIYNAESYFEKKLFDKDEE"
     gene            complement(47734..48648)
                     /locus_tag="KNP36_000045"
     CDS             complement(47734..48648)
                     /locus_tag="KNP36_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871948.1"
                     /translation="MELYEAIFYRKSVRNFSSKKIKKPLMEEIKRSCKNLEYLNEDLN
                     IKAHVVDRGHIIHFLMGKECKVKAPHYIVVTSDKGEDYLQNIGFATEGVVLRLTTLGI
                     ATCWLEGNLKREDILEFVDIGNKNFEEDEEDDLDYLAGIKTEEDDENKIENPYIIIAF
                     GYPAKNEELFRTRYARPDRKPVKDMINKINRNRKWKDILELTRRAPSVKNSQPWYFHK
                     DERGLHLFEKRPKKHCEDMNKVSLGVALRHFDIACIKNKIDVSYEKLPIRNKIGKSYF
                     ITVVEHVKPEEETQEENVTLEKEESQDE"
     gene            49249..50478
                     /locus_tag="KNP36_000046"
     CDS             49249..50478
                     /locus_tag="KNP36_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBF0871949.1"
                     /translation="MNLNRNLEKYAELAIKVGVNIQPGQILLIKSPIECADFARNALK
                     EAYKCGAKNVYIEWSDEESTLIKYLYAPDEAFHEFPKWTAEQYVDIAKEGGAFLSVYA
                     QNPDLLKDVDPERVANFQKASGKALKEWRSYTLTDKCKWSIVSVPTKDWAKKVFPNLS
                     EDKAIEKLWDAIFKCSRVDGQDPIKAWEEHNENLKSKMDFLNKNNFKTLKYKSSKTDL
                     TLDLPKGHVWLSGASKDPNGISFNPNIPTEEIFGMPHKFKVNGTVYSTKPLVYGGNII
                     DNFFLTFKDGKIIDFSAEKGLDTLEKLIETDEGSHYLGEVALVPYNSPISNTDIIFYN
                     TLYDENASCHFAIGSAYKTCLEGGNNLKDEELDEHGVNDSLTHVDFMIGSADMDIIGE
                     TYDGKQIQIFKNGNWAF"
     gene            complement(50683..53064)
                     /locus_tag="KNP36_000047"
     CDS             complement(50683..53064)
                     /locus_tag="KNP36_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homocysteine S-methyltransferase family protein"
                     /protein_id="HBF0871950.1"
                     /translation="MEIRQYLKNNILIFDGAMGTMLQQKGLKLGENPEVFGLQNPDKL
                     IEIHTAYLEAGSNVILTNTFGCNELKLDSKYTVEEVIDNAVLVARKAIENVDNTKPRY
                     VALDIGPIGEMLEPMGTLSFDKAYEIFKRQVLQGVKSGVDVIVIETMMDLYEAKVAVL
                     AAKENSDLPIFCTMTFDEGGRSFTGCMPECMVATIEGLGVDAIGVNCSLGPKQLLPIV
                     EKIASRATVPVMVQANAGLPNIVDGEAIYDVDAKEFFEGVKKFVEVGATIIGGCCGTN
                     PSFIKEISENINSVTKGCIEKIDKCVVCSPSKFVEVQSPTVVGERLNPTGRKSLQEAL
                     KNENVDYAINLGLEQVNAGAQILGVNVGLPEIDEKKLMPKLIREIQAVVDTPLQVDSS
                     NVEALEQGLRYYNGRTIVNSVNGKEESLESILPIVKKYGSCVVGLTLDEKGIPKKAEE
                     RFEIAKRIVNRAVSYGIKPKDIFIDCLSLTVSAQQEEAIETIKAITMVKTLGVKTILG
                     VSNISFGLPNRKALNASFLTLALGAGLDLAIINPNEYSMMEAINSFKILNNTDKGCIN
                     YINQYSNINNSKKSDSSTKIDKDLPLDILVERGLKDEAKNVTLNLLKEKDENYILDEI
                     LIPALDKVGKRYDSGDIFLPQLIQSAETVKVSLNTIKETLLSKSSNNVSKGKIIVATV
                     KGDIHDIGKNIVKIMLENYGYEVIDLGKDVPIEEVVEVAKKRNIKLVGLSALMTTTVQ
                     SMKDTIQALRDNEINAKVFVGGAVLTEEYAEEMGADYYSKDAKSAVEIAKLNF"
     gene            complement(53036..53761)
                     /locus_tag="KNP36_000048"
     CDS             complement(53036..53761)
                     /locus_tag="KNP36_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Vitamin B12 dependent methionine synthase,
                     activation domain protein"
                     /protein_id="HBF0871951.1"
                     /translation="MENNLIGREDISINQSEVLRYLQYRGQEIDKDLKYTIDECVAIT
                     KNKINPRYLSRIYPIKINKDNVVELEGTNLTLESKDVYELLKECNECVIMAATIGIDI
                     EKEIRRHSYSNLTKGLIIDSCGTTAIEEVCDIVQNNLEKVFLKQDKFITMRYSPGYGD
                     LPIEKNIDILNVLNAQKQIGLTITSNGIMIPRKSVVAIIGISNTRINKSKKEKSCENC
                     KNYRNCTYRKGANSCGNKTISEK"
     gene            complement(53751..54206)
                     /locus_tag="KNP36_000049"
     CDS             complement(53751..54206)
                     /locus_tag="KNP36_000049"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HBF0871952.1"
                     /translation="MEKVESFKLDHTKVKAPFVRKCSVLDGVKGDKVTKFDLRFLQPN
                     VESFGTAAMHGLEHLLATYLRDTLDGVIDLSPMGCRTGFYLILWGDVDAKTVKIGLEE
                     ALKKVLESDKMPAATAIECGNYRDLSLFGAKEYAKDVLDKGFSLNIYGE"
     gene            complement(54488..55669)
                     /locus_tag="KNP36_000050"
     CDS             complement(54488..55669)
                     /locus_tag="KNP36_000050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0871953.1"
                     /translation="MKNKSLLNHMFRPILDLIISCALTSMLILTSMYIIKSLYVNSDM
                     SVVNQLVYQARDFRSLIGYDLFYPFLFTITSLAIYSMISYKRNKQIVDFIRKTNRKNQ
                     KLEIIKSAVNLMDEGNLEKSIDIEYDLDILKDKEKDDIDELAHKINNIVHQLRNITIE
                     ERQAQQTKTDLITNVSHDLRTPLTSIMGYLGVIEEGKYKDEVQMMYYVDIAYEKSKNL
                     NVLINDLFELTKMQNNTIKLNKIEINLVELLSQVVSQFEIYFKQEFMVSRINFNEEKL
                     IVKADPNKLVRAFENLITNAVKYGKDGHYVDIVTEKKEDMAVVKVINYGEPIPVLDLP
                     NIFDRFYRVEKSRNRNVGGSGLGLAITKNIVNLHDGEITVSSDKYQTVFEVQLPIIQS
                     A"
     gene            complement(55659..56351)
                     /locus_tag="KNP36_000051"
     CDS             complement(55659..56351)
                     /locus_tag="KNP36_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0871954.1"
                     /translation="MNNTVLVVDDEKEIRDLIEIYLLNSGYNVIKAEDGKEALDILKK
                     ENIHLMILDIMMPKMDGIEVCRKVRESLNIPILMLSAKSEDMDKIQGIMTGADDYLTK
                     PFNPLELTVRVKSLIRRAYYFSGANNEDKDVIKVGVVIIDKEKHSVTVAGNEIILTSR
                     EFDILYLLANNKGRVYSTEEIFEKVWKEKYYQSNNTVMVHMSRIRDKIEKYTDGEKII
                     HTVWGVGYKIEK"
     gene            complement(56485..57201)
                     /locus_tag="KNP36_000052"
     CDS             complement(56485..57201)
                     /locus_tag="KNP36_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBF0871955.1"
                     /translation="MKKFKLIGAIILVVFISVFISKDRLLKKDKDPIVAAQHDSEQDV
                     EANSQNKNHSNSISNILLVNKTNGISKNYTPENITKVNIPFVEEATEEEKQMAGEPAK
                     AVEDLVKQANSEGIQFLGSSAYRSYDTQLDTYTRRVKSQGREKADAYVAKPGYSEHQT
                     GLCIDLTNPERWFVGSTKEAKWLAENAHKFGFIIRYPEGKEDITGTAYEPWHIRYVGK
                     DAAEEIYSKGLTLEEYLQNK"
     gene            57326..58060
                     /locus_tag="KNP36_000053"
     CDS             57326..58060
                     /locus_tag="KNP36_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiocytidine(32) synthetase TtcA"
                     /protein_id="HBF0871956.1"
                     /translation="MSIQKLLSKARKAIQDFDMIQENDKIAVGLSGGKDSLTLLHILK
                     SYQRFSPQNFELIAITLNTGGVDNSPLDKLCKEINVPFYEFQTDIKEIVFDIRQEKNP
                     CALCANLRRGALNDNAKKLGCNKVALGHHKDDAIETFLMSMFYEGRVNCFSPKTYLDR
                     QDLTVIRPMVYIEEYMTKKISKDSNYPIITNPCPANGHTRREYIKNLIANLNKEMPDF
                     KRNVFGALNNSEKLFIWDKEKIKNFK"
     gene            complement(58345..59196)
                     /locus_tag="KNP36_000054"
     CDS             complement(58345..59196)
                     /locus_tag="KNP36_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0871957.1"
                     /translation="MNSKIKYFLKFFILIFILIFIYSVAIEPSLLIVKKYNISENGAL
                     IKNDSIESKSESVKVVQISDTQIGSFYSTKNLKKVANKINTLNPDIIVFTGDLIDYSN
                     KNPSVDEITTILSSMNARLGKFSVFGNHDYMYKLPRYYRQIMKNSNFNLLVNENKKIK
                     LKDDKYINILGVDEILNGNPNIKYLESQIDNKSFNLLLAHEPDLVDMLSKDTMNLVLS
                     GHSHGGQIRLPIKGALVTPPYGRKYTKGFYDINGNHLYVSSGLGSTKLPFRFFNIPEI
                     IEFNIII"
     gene            complement(59222..60160)
                     /locus_tag="KNP36_000055"
     CDS             complement(59222..60160)
                     /locus_tag="KNP36_000055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBF0871958.1"
                     /translation="MKSILIMGGSDFIGSALAKRLIKCGYQIDILTNGKKEIDYNGFK
                     EHLICDRKVRKDMENIITGRKYDYIYDMTAYTKEDVSNLIDFISMDNLKKYIVLSAGA
                     VYKDSGRNIKEENEKGENENWGKYGLNKKEAEDFIINSPIPYIIIRPTYIYGENNNLY
                     REYYFFEKIEKNEKIPVPKGKQVSNQFIYIGDLVKVLESIMKNPHVREAYNVTNPQLI
                     SWDDLIYTCGEIIGKEPIIKYVDMEKVEFRERTYFPFRNIDFNLDINKLIEHGLYIPN
                     VLLKEGLTATYKWFSANKPKMHDRKMNKVESVMQIV"
     gene            complement(60263..60913)
                     /locus_tag="KNP36_000056"
     CDS             complement(60263..60913)
                     /locus_tag="KNP36_000056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBF0871959.1"
                     /translation="MKKNYEIVLFDLDGTLTDPKEGITKSIQYSLNSFGIKEDLENLD
                     QFIGPPLHDTFKEYYKFEDKKAKEAVEKYREYFADKGIFENKIYENMKEILEMLYKNG
                     KILLVATSKPTVFAETILRYFDIDRYFKYIAGSNLDGTRVNKNEVIQYVLDLCNVKDK
                     DKVIMVGDRKYDIIGAKKIGIDSIGVLYGYGSFEEISESEPTYIVENVESIKDILL"
     gene            complement(61062..61250)
                     /locus_tag="KNP36_000057"
     CDS             complement(61062..61250)
                     /locus_tag="KNP36_000057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HBF0871960.1"
                     /translation="MKAFVDKDVCVACGACIGTCPDVFSMSDEGHSVAIEGEIPADLQ
                     DLCKEAEEGCPVSAITVK"
     gene            complement(61357..62541)
                     /locus_tag="KNP36_000058"
     CDS             complement(61357..62541)
                     /locus_tag="KNP36_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBF0871961.1"
                     /translation="MKNLLIRNGTIISPTDGIKFEKRDILVLHGKIYAIGLNLKEKIR
                     KEKLLTNKEFEIINADNMYISPGFIDVHTHCYKRKLPTGMDSDSIGIEKGSTVIFDAG
                     TAGPSNYYDFKKKYMDECKTEVYSFLNVTNEGLNILNESTYLDVINFDKVESIVEKNI
                     EKIKGIKVKASKFQSNESGIDIIKKSKQVAKKLNLPLVVYIGEYPSYIDEVMNILGKG
                     DVVTPVYGNSTNGILKESGTLRKSVINAKNRGVLFDVCHGVDQFDFKVFKKAIKQGLE
                     PDLISTDMHIKNMKDVNYSLLNVINKIMELGISLEKCIEKVTEYPTKIFDLHGNKGRI
                     KIGGEGDFTIFTMEECNDIIKDYNNNELVLNKKLRLQYTVKSWMKSSEVYRHGYENTI
                     IN"
     gene            complement(62683..63600)
                     /locus_tag="KNP36_000059"
     CDS             complement(62683..63600)
                     /locus_tag="KNP36_000059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SufD family Fe-S cluster assembly protein"
                     /protein_id="HBF0871962.1"
                     /translation="MNKIDLNLLEKVAELRGTPLGAYNIRKNGQGVERHSTENVTIIP
                     KTDKPGIDIIVKPNTKGENVHIPVIVTEAGVQDMVYNDFEIGENADVVIIAGCGIHNC
                     GCDDSEHNGIHRFFLRKGARLKYVEKHYGEGDGEGKRILNPVTIVNMDEDSYCEMETI
                     QIKGVDSTKREMDANLGKGAKIVVFEKLLTHGNQVAESNMKVILEGENSSAQVVSRTV
                     GQDNSKQKFNPCVIGDSLCSAHVQCDSIIMGNSQISAIPEIAANHPDALLVHEAAIGK
                     IAGDQILKMMTLGLTEEEAEQQILNCFLK"
     gene            complement(63622..64350)
                     /locus_tag="KNP36_000060"
     CDS             complement(63622..64350)
                     /locus_tag="KNP36_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0871963.1"
                     /translation="MLEIKNLSFNVESNNEELGIINDVSLSFERGKLIVITGPNGGGK
                     STIAKLIMGIEKATSGQIILDGEDITNLSITERAKKGIGYAFQQPPRIKGMTVENLLT
                     LAHGKPLSTDVCCQYLTDVGLCSKDYLNREVDNSLSGGEMKRIEIATLFARDLKVSIF
                     DEPEAGIDLWSFGKLNESFKKIHEESNQTIIIISHQERILELADEIIVLQDGSVKSHG
                     TKEAILPEIMCQVNSSCELMKDMN"
     gene            complement(64546..64746)
                     /locus_tag="KNP36_000061"
     CDS             complement(64546..64746)
                     /locus_tag="KNP36_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871964.1"
                     /translation="MFKKMAVLKDIATKIGRKKAYELLEMVEGNDAFVAEVKIKKNGI
                     ESKKEEIMLKDNQKIILEYIEG"
     gene            complement(64871..65251)
                     /locus_tag="KNP36_000062"
     CDS             complement(64871..65251)
                     /locus_tag="KNP36_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBF0871965.1"
                     /translation="MINKIGKITLYVNNQEDAKLFWTEKLNFVVTYEKEMGPNMKWVE
                     VAPSKNEFTTFVLYDKNLMMKQNKEINVSHPSIILSTRDINGTYEQMANNEVEVGELM
                     EMPYGRMFSFKDQDGNDYLVREDK"
     gene            complement(65524..66882)
                     /locus_tag="KNP36_000063"
     CDS             complement(65524..66882)
                     /locus_tag="KNP36_000063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0871966.1"
                     /translation="MFIRKNVIKLAIPIMIEQTFVMLLGVFNTMMAGHIGEEAVSAVG
                     MVDSINNIFISVFAALSVGATVVVAQQIGKKDSEKVNETIKQALVSGVILSFTITILM
                     WVFRTGVINLFYGSAEELVKSNAKLYIEFTLFTYPFIATQQIANGILRGCGDVKKPMY
                     VTMFMNIVNVTLGYILIYGIDLNPLGINLQTPSYGITGAAISIAIARIIGCIVIIRAL
                     FKGNEFISMGKIFPFKIDVETQKSIFNIGIPAGVEQLLFNAGKLIVQVFIVTMGTSAI
                     ASNAIGMSIASIINVIGNALALSATTLVGQYIGRGDIKGAKSTLLYLTKFATICLFIV
                     GAIFIPIAPWISSMYTQNASVIDISTQLIRSDCLAMVIWPISFVLSAGLKGAGDTRYT
                     MMTAVIGMWIFRIFTGYVLGVVLEFGVLGIWIGMYTDWLVRGTLYCLRLRGTKWLKHK
                     VA"
     gene            67330..67782
                     /locus_tag="KNP36_000064"
     CDS             67330..67782
                     /locus_tag="KNP36_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="staygreen family protein"
                     /protein_id="HBF0871967.1"
                     /translation="MVNLNANNLNVNMVYPISSTAPIRFRRYTVSYLENMENIYLTIA
                     TYFDTLGLGTMNIDKVYGQWAWFTDNIYDLNLFVFVGNYPYQIAKNRYDTFVDILPVA
                     ITSIVNGDRVFLISNPCLLNSKITVRFISSHPTLNRTVDYGNIRDFIF"
     gene            complement(67939..68556)
                     /locus_tag="KNP36_000065"
     CDS             complement(67939..68556)
                     /locus_tag="KNP36_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF488 domain-containing protein"
                     /protein_id="HBF0871968.1"
                     /translation="MEIFAIGHSNYPYDKLINMIKKYDINCVVDIRETPYSKYNIQYN
                     KEAFNESLRNSGFLYIYMGKEFGAKRTNKDVYTQEGYADFEKVAKEDIFLNGIERLKK
                     GCQMGYRIVLLGAMQEPIRCHRSILVGKVLNKEGFDVKYIMHEGNLAYQEDIEESLLD
                     KYFSDRKQLSIDNLLGSALTREEMIQEGYKLANKEIGYRTEKLGK"
     gene            complement(68979..69791)
                     /locus_tag="KNP36_000066"
     CDS             complement(68979..69791)
                     /locus_tag="KNP36_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0871969.1"
                     /translation="MFSIGMFSKINKITTKTLRYYEDIGLLKPEYVDEFTKYRYYTTE
                     QLPKLHQIITLKQMGLSLAEIKKAVENPEEVENILMNKEKEMLDVIKSEEYKIIKLRN
                     YLMNLKGEVNMNDVIIKSLPKVKVASMRKVLKGYDELFNLFPNVMAEEMMKTGCTCAV
                     PDYCFNIYHDGEYRETDMDVEMCQAINDLKEDTDILKFKELDAVENAVCILHNGPYST
                     LGKTYADAFKWIEDNKYKVVGNPRESYIDGIWNKESEEDWLTEVQIPVKRML"
     gene            complement(69867..71285)
                     /locus_tag="KNP36_000067"
     CDS             complement(69867..71285)
                     /locus_tag="KNP36_000067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium/proton antiporter"
                     /protein_id="HBF0871970.1"
                     /translation="MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDG
                     MVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMAKPVAIPSILMSSLGVIITAGVT
                     GMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP
                     IAYMLTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFY
                     TIFITAIAILSYAFSEYLGGNGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIM
                     LFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLAKFKFSNKEKLFISWVG
                     LRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDNTP
                     VLKTFNDYDGEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGS
                     TIIKTGDILVLSGDRIEELIQL"
     gene            complement(71769..72686)
                     /locus_tag="KNP36_000068"
     CDS             complement(71769..72686)
                     /locus_tag="KNP36_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2268 domain-containing protein"
                     /protein_id="HBF0871971.1"
                     /translation="MVNMNIIEIRSDKIYKKIMDAPINKKEDIYRYELMKPFEFKWKC
                     MNVPIVARQKGGYDVIIASEMLGVLSPKDIDEKQKKNINVLSADKIWGTCKETIENSI
                     NAFIKEGYDLNIKDYKYSILLANPNSPYTILSDGYWGDGGIPGYIFLSLVPNEYTINR
                     LPVLIAHECNHNIRFQFIEWNNNITLEEMMINEGLAENFATWMFGEEMLGPWVSRTDI
                     ETLNTYIKPIIKSALKETGFQNITSYLYGDDIAKMQGYFPVGLPYCAGYACGYYMIKY
                     YLEKTNKSIIEATLLPYSEIIEAVKEFWE"
     gene            72948..73325
                     /locus_tag="KNP36_000069"
     CDS             72948..73325
                     /locus_tag="KNP36_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBF0871972.1"
                     /translation="MLTPYLIFNGTCEKAFNFYAEAFGGGKTIFARLDSNPNNPIMHA
                     SVTFTKYEGCIMGADTDKPVVISGMAICVVLPSREAIEEISVKLAEGGTLVQEFLPHP
                     PPHQNDGAAEVLDRYGYTWYLST"
     gene            complement(73481..73930)
                     /locus_tag="KNP36_000070"
     CDS             complement(73481..73930)
                     /locus_tag="KNP36_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0871973.1"
                     /translation="MKSGIILEMKQINSTEYDEMLQVWESSVRATHDFLTEKDIESLI
                     PLVEIGLKEVENIVCIKDNDIIKGFIGIDKDKIEMLFIEDKYRGNGIGKKLIKYAIDK
                     YNVKYVDVNEQNKKAVGFYIHLGFKVFDRSEIDGQGNPFPILHMKLI"
     gene            complement(74094..74498)
                     /locus_tag="KNP36_000071"
     CDS             complement(74094..74498)
                     /locus_tag="KNP36_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmaF family protein"
                     /protein_id="HBF0871974.1"
                     /translation="MSYQNYKCERDYVYDDYKYNKCNKCYNDYEEMTHVHEYSESVKL
                     AEECEDRHNHRAAGVTGEVIPINGGTNHVHKINDNVDFLDHFHKICVTTGPAIRIPGT
                     DKHIHLICGETTVNDGHCHKFLFTTQIEAPLV"
     gene            complement(74611..75477)
                     /locus_tag="KNP36_000072"
     CDS             complement(74611..75477)
                     /locus_tag="KNP36_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBF0871975.1"
                     /translation="MIDIHKNIYDNKLFEELKIDCKKCFGLCCVALYFSASDGFPINK
                     ESGKPCINLQPDFKCSVHNSLIKRGFKGCTAYDCFGSGQKVAQVTYKGIDWMQSPELT
                     NQMSEVFLIMRQLHEMLWYLKEASVLNISDTIKSKIDLIIEETEKITNMGPEQIINLD
                     IISHRTKVNLLLSQASESMMGKVKSFIKTSTLKNMKKLSKNIDLIGADLRKINLIGAD
                     LRGRFLIAANLRNTDLSGANLIGADLRDCDIRGANLENSIFLTQLQVNTAKGDSSTKL
                     PASLIRPKYWEK"
     gene            complement(76047..76391)
                     /locus_tag="KNP36_000073"
     CDS             complement(76047..76391)
                     /locus_tag="KNP36_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HBF0871976.1"
                     /translation="MENLPNCPKCNSEYTYEDGTLLVCPECSHEWALGLGAEEDSNII
                     KDVNGNVLNDGDSVTVIRDLKVKGSSSSIKIGTKVKNIRLIHDSSDGHDIECKIDGFG
                     AMKLKSSVVKKA"
     gene            complement(76580..77197)
                     /locus_tag="KNP36_000074"
     CDS             complement(76580..77197)
                     /locus_tag="KNP36_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0871977.1"
                     /translation="MISLINISKKFKDKSIIDKFNLEISKGEFVAITGNSGSGKTTLL
                     NIMGLLEKPNSGDIIINNIKNPNSKQIRILQRDFYGYLFQNYALIENENVENNLKIAL
                     KYQKNINHNEKINYALESVGLRKYNKKKIYELSGGEQQRVALARVILKECEVIFADEP
                     TGNLDKKNRDIVFDILKSLNKNGKTIVFVTHDLDLSEQADRVIKL"
     gene            complement(77202..79364)
                     /locus_tag="KNP36_000075"
     CDS             complement(77202..79364)
                     /locus_tag="KNP36_000075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="HBF0871978.1"
                     /translation="MKKIIYVLFTIELLIVSLLGLNIVKDNEINNILYNDTTSISVMF
                     KDYKKLNKNYSKWIKDIADENNVAISKYVFNNNEKLSIYTTDTSLNNNIKLKSGKFPN
                     TNSNEFISNINTNNSNQVGKFSTMSKDISILIRDFGKISEVGESGILYISTQNEDTIN
                     KILRELNVDRSIFVARLHDRYVNSNLYLNPSIIRDLILIILCFLATIIHYSISVSREA
                     SILRLNGYSKLDIIARVIKNILRIMILSSVTALLIYIIYILKLNIGVRACLYFAMFSI
                     ICILINILISILIVGFNSRSSKYVLSLNGKKSYGFVNIMHFTLKIVFVSFLILSINNC
                     ILNYNMLQTQLGNLSEWDKAKNVYNLTLKDTGEQSLGKEEVIKNAKIKGFYKNLVEEK
                     DAFLIDSTNFEKLEDGSYMYEINSKGKNPEVSQYGKNIKINKNYLKVNPIYSNGKEIF
                     NLIDYDDKTINLLVPKKLQVHENEIKKEFRELFYFEKIEVENMYNKELNRELNKTKKS
                     DLNVNIIYVDNNQSYFTYNSLVMDDNRNLIDDPIAIVDIDNIDDSFYLSYISRCVYFN
                     SKKLDALADISSIIEAQGVEAHIQSLHAVYNEYGLEINKLEKYLNSEIFTIIIIAISN
                     LMITYNIVASYYERNKYKLYIKKIFGYSTTARSMLLIVSLILTNIIPIGIISTRVDLS
                     NNIILFGLLILVIEVIVSIVLDKIISNSSFNKIIKGEH"
     gene            complement(79706..82213)
                     /locus_tag="KNP36_000076"
     CDS             complement(79706..82213)
                     /locus_tag="KNP36_000076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0871979.1"
                     /translation="MKEDIRLHRMCKKEQATKNEVISEDILKSMSIGVSKHFLDDSFT
                     IIWGNTSFYQLLGYTEEEFLVKFSSLKDYYEQNLYHFESMKNHFLEAYHHGEKSIEYQ
                     ICISANNGDPVWVIMTGILIESQDNEKSMVYILYSKINELKIKQEELSDMEKESTENF
                     KWMMSEYAGNVYISDMDTYELLYLNKHSCNTLQASANELIGRKCYEVIQGRTSPCPFC
                     TNSYLKKDDIYEWEFYNKKLKRTFIIKDRMLNWQGRRVRIELSYDMYSAEYKLAKKDQ
                     ERESILKTIPAGMVRLDARDYLTILWCNDIFLNMIEYTKEQFAEELNNQCGYLFSEDY
                     KRSKKLAQDLKESGDNVVFEAKIYTRSREERIWTVTLCYISGEDSWDGIPSFYSIGID
                     ITKERKQIEKLQHISEKDALTGIYNRAETERQIKKYFEKNLNVMGALFMIDTDNFKQI
                     NDTEGHMIGDIVLTEMASGMKKIMRDSDVVGRIGGDEFTIFMKNISSVKDAEKKAEEL
                     LYMFRHLFQKEKSFLKVTCSIGIAIYPKDGTTFKEIYARADKALYQAKNMGKNNYVIY
                     NQDYFKELEEFDCSSLGTVIDSEKQYAEYPDNLTRYIFRMLYQTDDIDQAINMILEVV
                     GKQFDVSRVYIFENTEDGRYTSNTYEWCNEGISSQMAYLQNSNYQDYEDYEKLFEDEL
                     VFYCRDIHTLSPKLEELFSSQGIHSTLQCAYKEDRVFSGFVGFDECTGLRLWSQEEIS
                     TLSLISQIISMFLQRKKNNKLNQQIQQYQNILDNIDQCICVINKENNFLLYVNKKFKN
                     TYSKFQIGQPYYLDSIDIHKISIIWNKKEAYLCTSTI"
     gene            complement(82690..83322)
                     /locus_tag="KNP36_000077"
     CDS             complement(82690..83322)
                     /locus_tag="KNP36_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketohydroxyglutarate aldolase"
                     /protein_id="HBF0871980.1"
                     /translation="MKKMNITKRMSECGALAIVREENLNRACEIAEGCIKGGITVIEM
                     SYTLNNAGEIIQGLNKKYGEILCVGAGTVLDSETARHAILHGAQFIIAPNYNEGVAKI
                     CNRYQIPYAPGCTSLTEAVDALSLGATFIKAFPISDFYGPKLVKVFKTPIPDMPVLAS
                     GGLNIENLHIWLENGVDVCGFGGLLTKGSVEDIAKNANKIREIIKNVRKI"
     gene            complement(83428..84333)
                     /gene="dapA"
                     /locus_tag="KNP36_000078"
     CDS             complement(83428..84333)
                     /gene="dapA"
                     /locus_tag="KNP36_000078"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBF0871981.1"
                     /translation="MKYKGIICAMITPFDENQNINSQATCQLIDYLIEKGIYGLFILG
                     TNGECHVLTDDEKVEFAKIVINHTNNRVPVFVGTGGNSTREVVDLSKRMEAIGASALS
                     IITPYFVTPTQQELILHYKTIANSVNLPIIMYNMPGKTGINIEPESVRELSKIKNIVG
                     IKDSSGKLDNMKAYIEATKNENFSVFSGSDSLILDSLKAGSQGAVAATTNFLTEIGIS
                     IYENFMKGDLEEAQKSQSSIEELRRILKLGTIPSVMKKTIVLNGINVGTARLPVTEPT
                     GEVLEEIKRVVENYRTILNKSSENR"
     gene            complement(84338..84937)
                     /locus_tag="KNP36_000079"
     CDS             complement(84338..84937)
                     /locus_tag="KNP36_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBF0871982.1"
                     /translation="MENTLSEFLDNISNELSEFIASIDETSINKACELILEAEKNHGR
                     VHVTGIGKPGHVSGYISSLLSSTGTSAYILHGTEAVHGSSGQVVEGDVVIAISNSGET
                     QELKATLKTLKVNGAKIIGVSGNESSFLKNISDIFLFAGVKQEGDCLNKAPRASILAE
                     TIILQSLSVVLQYAKGLNTQEYLKWHPAGSLGKSIREGI"
     gene            complement(84995..86266)
                     /locus_tag="KNP36_000080"
     CDS             complement(84995..86266)
                     /locus_tag="KNP36_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIC"
                     /protein_id="HBF0871983.1"
                     /translation="MEFIISLLSTPAVLLGVVACIGLILQKKSAVEVFTGSSKTLIGF
                     LIFGIGASAMTGALQNFNKLFQHGFGITGVIASPEAATALAQGTYGFAVSCTLILGFI
                     LNLVFARITKFKNIFFTTGHSLFFSCVLVLIMKAHGFDNTITILIGGTILGFMSAALP
                     QFCQPFMRELTGGDEQAIGHFNMIGYGLSGYIGRLFSKHKDDTTETIEFPKWLSIFRD
                     FLMGLSIVMLILFYIATLKAGQAFTQEIAGSTHWLVFPLIEAFTFVAGMSILMSGVRM
                     FLAEITAAFVIISEKYIPGSRPALDVPTVFPYAPNAVIIGFISAYAAGLLAIAIMASF
                     PSIFPVVIIPAAHICFFSGGTAAIFGNTSGGWRGAIAGSFVVGLLLAFLPVILYPVYG
                     TLGIEGATFPNIDYNVVGSILHNILQFIKPI"
     gene            complement(86293..86580)
                     /locus_tag="KNP36_000081"
     CDS             complement(86293..86580)
                     /locus_tag="KNP36_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0871984.1"
                     /translation="MYKILIACRAGVGSSLMLKIKTQQIIKENNFPIEVEHGSLDSLN
                     GFNGDAVETLIDVAEELKNKNLKFDIIGIHNIVDRNEIKTALEKFLASKEG"
     gene            complement(86595..88682)
                     /locus_tag="KNP36_000082"
     CDS             complement(86595..88682)
                     /locus_tag="KNP36_000082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0871985.1"
                     /translation="MVVDKEIVSILQILLNSTLITTNGLQEESNSSKRQITYRINKIN
                     DMLKVKNVPLICLRADKDIIVRKETKKAIKEILEKNYSKNTYYFSKTERLLYMYLMLF
                     INMDDISINHFINSIKVSRSTVNLDFKDLIPELEKKNIKVKNNRINGYYIVGNEMEIR
                     RVLIKNIIETLSNEKSSRVFDIFIKEYNLDSFEEAKKIILKLIKKYEITFVEDRLVEF
                     IYIFIFLKARMYSTRIVTQENVDIPNISVMSSMKEYKFAKELLEVYGSEDKIKPHNIM
                     YISAWILGISVGNYEEDTEDKDVISKIVNKMMTKFGYLSGVYYISQEKIFKQLYSHFR
                     PAYYRLLFKLPIYNPICEKVKEEYKLVYRIVSNAMKEFCGLFGEEIQEEELAYLTMHF
                     ATLFSNKKEFDGFRKRIALIVCSNGVGSSAILHAELTNLFPDLHFIPMSESVGLENIS
                     EPVDIVFTTNYNAEGLKTDVPVIKVSPVMTTKEKYKITREVYIQLGDIFLRQPKIDEV
                     MDIIKKYANVTSESILSSELLAYFTQIENFTSKEGEGPMLSEITNETLVKIKVKAKNW
                     EEAIRQSASVLVENNKVTEGYVDAMINSAKASGPYIVITKHVALPHARPEAGSKEIAI
                     GIATLDSPIEFGNNENDPVKYVFCLSAIDNNSHLRAMSELVELLEEDEFFKVLDSAKE
                     AKEIIDFIKTHEL"
     gene            complement(89097..89618)
                     /locus_tag="KNP36_000083"
     CDS             complement(89097..89618)
                     /locus_tag="KNP36_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBF0871986.1"
                     /translation="MVLLIVDAQKLITNERLYKFNEFVVNVENLIDTARKNNIEVIYV
                     RHDDGVENELTKGKNGFEIYEKFKPCNGEKIFDKKVNSAFKETGLLEYLTNNGEKDII
                     IAGLQTDYCIDATIKCGFEHGFNIIVPAYSNTTVDNFFMSAEQSYKYYNEFIWNERYA
                     KCISLEETLRKMK"
     gene            complement(89680..90486)
                     /locus_tag="KNP36_000084"
     CDS             complement(89680..90486)
                     /locus_tag="KNP36_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBF0871987.1"
                     /translation="MRTEKSLKRPIASFIILTNIIFLPLFLLVVVTIMLKLPTVISDI
                     ALCISAWSSTFAFMILFKKIYPGKKFLVHVKDRFRNKLKFSTVSIIISIQVLIAVVVI
                     FILASKNHGIMPNFTVSSWGAFIYLFLKNLFAGSLGEELGWRGFVQNHLQKRHSPLKA
                     SIIVGFWWGMWHLPIWFTTGFKGLDLIKYIIFFMIAIISISIIMTTFYNLNKTLIIPI
                     VIHQLFNFLIGIINGDLIELINYYAMLYLIFAIALIVINPGNVLYKNIRE"
     gene            complement(90590..91384)
                     /locus_tag="KNP36_000085"
     CDS             complement(90590..91384)
                     /locus_tag="KNP36_000085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0871988.1"
                     /translation="MYTIGQVSKFLGISRDTLKFYEDKGLVNPKKNDENGYRIYNQVD
                     IYDIATINFYREIDIEIKKIQEIRKSKSINNLELLLEEKEQIILKEIEYKKLLLKKVQ
                     LVKEDCDKIKTYFGKYTIKEMKPLEVKGKIKHVTNYEEYEALKENTNNLKKAVTLTDL
                     RRVINFNEEGIIEEKFIIVREVDDYNKIIEGEVLSHPNCIYTIIEDGRWSTGGENIDN
                     KVEDRLREIAIENECELLGIVYVNILLTTYEEGIERIFLEIYAPIK"
     gene            complement(91918..92772)
                     /locus_tag="KNP36_000086"
     CDS             complement(91918..92772)
                     /locus_tag="KNP36_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase"
                     /protein_id="HBF0871989.1"
                     /translation="MAMGFEFKIMRSLIYVGLAKEEYRPKLMDWLYRHHIPDSISTFG
                     PYCTKYAFYQAYPTPNEGERFGARKMQLTEHYWLVDEHMPEMANRIMTEYMPMDVLRW
                     QGCIPDVENKRVHENAESGDAGRAVGGDNGCPPFIFAFVPINWEEDFRGKGRTVQDGP
                     NYRWQFMIKYPDGISKEEGEKWFYDEVVPYFTNCCYVNRFVSSKIMINYGATAFDRVS
                     ELWFEGEEEWYKAVVEETKSFIKKPEWAQEEEFPYLKPQFNIASVFLGDIATMDAYSQ
                     YRGYIPMR"
     gene            complement(92804..93316)
                     /locus_tag="KNP36_000087"
     CDS             complement(92804..93316)
                     /locus_tag="KNP36_000087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1097 domain-containing protein"
                     /protein_id="HBF0871990.1"
                     /translation="MDRKKKEILTLSMGIALLPPLWAVLAPYIGIKTGAVALICAGLY
                     VTNGNKQKDGLKIMFGFWCGDLWAVLAILIMGYMNFNQNLELFLTLSILGFFAVVIAS
                     LFEKIIFLPSWLCGWAIGLTIMTGENIINLQDICIQIAVAMAVGVWYVGAGVDLFTIY
                     ILSKDRKKGN"
     gene            complement(93309..93533)
                     /locus_tag="KNP36_000088"
     CDS             complement(93309..93533)
                     /locus_tag="KNP36_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871991.1"
                     /translation="MNEKSSFKQIEIILAVIFLVLTYYKVRLTPAFIVIFIPLYLSYF
                     AVSMIVNQIAIKLLEIRQAREATNYNIGNG"
     gene            complement(93593..94546)
                     /locus_tag="KNP36_000089"
     CDS             complement(93593..94546)
                     /locus_tag="KNP36_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBF0871992.1"
                     /translation="MKILGISFGTKNGNNDTMCKVALKGAKEAGAEVEFIQMSSINIK
                     HCTGCCACVKTLLSGKGSMCVLKDDFEWLLDKMKDADGIVVSDPIFEEGASGLFHTIM
                     DRFGPRADRGNNIIGTKVAEAIGGKIPDSRMLNDKVISFMGIGGSDWGTRVQCEHAML
                     ALIPMWKVIDNAWFPWAKELVMDDTRLVQVHQIGLNIVEAAKDFEKASYQGEEGVCPH
                     CHNRLFYLEPGTKKAICALCGIVGELDTISGKTIFSFPEEQLGHAHDTLPGKFIHGDD
                     IKKMEGHYAEVRKTQEFKERKTSYNFIEPLTKEKQAGVSLG"
     gene            complement(94574..95962)
                     /locus_tag="KNP36_000090"
     CDS             complement(94574..95962)
                     /locus_tag="KNP36_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0871993.1"
                     /translation="MEDKFYAKGNGNNGYIKNLEVCSFNNLDGTCGMFQMALYKRDEK
                     YYLYGCCFGGNKKNGVMISDITDPYNPQFIKHFQMLDPKEYPTTTTPKIQIADDLMIV
                     AMSCGSGPGALVDQAKLANIKCEAGIRIYSLKEDPLNPKFLGYWDCGLKHVMGVHRFM
                     YNGGRYVHLSSDCVGFEGLIYRVIDIINPTNPVEIGKWWRPDQYANGYPNRTFDAGAP
                     HCPEFMDKGWLHGPPFVRDGKAYCGYGGAGLVVLDVEDLTRPRCLGELPFMPAFSSRL
                     AGARTHTALPLPGRDLVVVQNEGERFQFFKPDNITDVQAMNNIHMVDVSDPTKPTLIA
                     QFPYPEVPKDFPYPNFNVAGLGKPGPFGPHNLHEPMDNKPWLEQRGDRVYCCYFHAGL
                     RVYDVSDPYYIKELAYFIPPNPNKTPEESYFPGFPGPRLAVTEDLIVDDRGYIIIDAL
                     DDGFYILKMKED"
     gene            96235..97116
                     /locus_tag="KNP36_000091"
     CDS             96235..97116
                     /locus_tag="KNP36_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0871994.1"
                     /translation="MNTKQLEYFISVAENLSFTKTAEKFYISQTAVTQQIKALEEQIN
                     VTLFTRSKRHVELTPAGKVFLSEARTIIKNINDAIAKTQQFAHGFFGTLSIGTLIGYE
                     KNKLQQYLKEFSNTYPNISMDICTNEITELLNLVKNNSMDLAFVINPENQPLKDFEYK
                     TVERYSLVALLPPGHPLYNEDSIDLIELQHDKFIFVKETGDEYGQKSMIQNRYREAGF
                     VPNVVQRSNNLNTIESLVSSNMGISILPSFCVTDTMIERDIAIVPIKEVENRIEVVVV
                     WNKKNTNPALEKFISII"
     gene            complement(97304..98296)
                     /locus_tag="KNP36_000092"
     CDS             complement(97304..98296)
                     /locus_tag="KNP36_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HBF0871995.1"
                     /translation="MNILAFGEIMMRLSVPDYKFLTQTNELNYITTGTGLNILSGLKN
                     FGYNTYMLTKLPNNNVGKASSANIRKLGVKDDFITYGGNHIGVYFLENGYGERPSEVT
                     YLNRLNSSFCESKLQDYDIDKCLEEMDIVHICGIAMQLTDSVKEIALELARKSYEKGI
                     KVFFDFNFRQSLNPERTYDDLVNDYKKILPYCHGLFASYRDINKILNIDSLNIKSSSE
                     LIKKEYDIDIVAGTMRRFDDMNNRFIKGYISNDDGYFESREYKLEIYDRVGAGDGYVA
                     GIIYSYLENMKSEDIVEFGVASSVLAHTTYGDNSLVSTGHVLRLMNNEKIDILR"
     gene            complement(98301..99041)
                     /locus_tag="KNP36_000093"
     CDS             complement(98301..99041)
                     /locus_tag="KNP36_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KDGP aldolase family protein"
                     /protein_id="HBF0871996.1"
                     /translation="MNCIPQYYKNRVCLNVLAGSIKNAKEVYDACDGHVLIGILSKNY
                     STVEAAIEDMKKYSKEIDNAISVGLGAGDPNQSNMVSQISKELQPQHINQVFTGVATS
                     RALLGQNDSIINGLVSPTGKPGFVKISTGPLSSKEKDGIVPIETAIAMMKDMGGSSIK
                     FFPMGGLKTKDEYIEVAKACAKHNFYLEPTGGIDLDNFKEIVQIALDAGVEKVIPHVY
                     TSIIDKETGETKVEDIGVLYKIMKELLG"
     gene            complement(99106..100215)
                     /locus_tag="KNP36_000094"
     CDS             complement(99106..100215)
                     /locus_tag="KNP36_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DgaE family pyridoxal phosphate-dependent
                     ammonia lyase"
                     /protein_id="HBF0871997.1"
                     /translation="MSSIFEKYSVRRVINASGKMTILGVSTVDKEVIEAIGEGCKNFF
                     IIEELINKTGEYIANLLGCESALIVSSASAGIAQSVGAMIAKDDMSLVYNVNNPKKQV
                     KREIIIPKGHNVDYGVPVEVMIRLGGGEVVEAGYANMCNKEHIIREINENTAAIMYIK
                     SHHCVQKSMLSVLDAVQVAKEYNLPLIVDAAAEEDLNVYYELGADLVIYSGAKAIEGP
                     SSGLVIGKKKYIDNVKLQSKGIGRAMKIGKENIVGLTCAIERYISNDKVTLKEMEDKL
                     NPFIDKINTIKGVSASITRDSAGREILRGEIDFNEDIINKSTQQIINELRSGEIAIYT
                     RDYKANEGKIEIDIRSVTGSDLDTIYNRIKNIVES"
     gene            complement(100233..101366)
                     /locus_tag="KNP36_000095"
     CDS             complement(100233..101366)
                     /locus_tag="KNP36_000095"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase/deacetylase family
                     metallohydrolase"
                     /protein_id="HBF0871998.1"
                     /translation="MKIDILIKCGKTVDKSIIDIAILDDKIIEVKNQIDDSKYQANQI
                     INLDGEKFISAGWIDIHTHCYERLDLYKDYPDEVGIKSGVTTVVDAGTTGALDIGKFY
                     EDTKKYKTNVYALINIAKQGITSQDELSSMMNIDEYELRRAVKKYKDFVVGIKARMSK
                     SVVISNDVEPLKVAKRIKNELNLPMMVHFGSSPPTIEDIFDYMEKGDILTHIYNGKPN
                     GILRGNEVKKEIIEARERGIILDVGHGTESFSMDIAMKSKDAGIFPDTISTDIYIKNR
                     INGPVYNLSTTMEKFIYMGYSLEDIIDKVTKNAADAISLKNKGLIKEGYDADLTIFDV
                     VNEEKELQDSLNKSVITSTSIKPRAVVVNGEYLNIGKSIGENE"
     gene            complement(101368..102462)
                     /locus_tag="KNP36_000096"
     CDS             complement(101368..102462)
                     /locus_tag="KNP36_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
                     /protein_id="HBF0871999.1"
                     /translation="MERRLGISVYPEHSNMEDDKAYIKMASKYGFKRIFMCMLSITRP
                     KEEVKKHFKEIITYARELGFEVILDIAPNIFDILQISYDDLTFFSELNASGIRLDYGY
                     DGSKEAMISFNPYDLKVELNMSNDVAYLDNIITYKPNVNNIYGCHNFYPQRGTGLPYD
                     FFVRCSNRFKKYGIRTAAFVNSKYATIGPWNINDGLCTLEMHRNLDIATATKHLFATG
                     LIDDVIVGNAYASEDELKRMSEVNKYQVVFNVVTEEKTSEVEKTIMANEQHFRRGDIT
                     NQVARSTEVRKKYAKENFPKHDNTTIFKRGDVVIGNDDFGKYKGELQLILQDCADERK
                     NKVGRIKEDEIILLDFIEPWSKFKLILEGE"
     gene            complement(102599..103900)
                     /locus_tag="KNP36_000097"
     CDS             complement(102599..103900)
                     /locus_tag="KNP36_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872000.1"
                     /translation="MEKFASFLERKIMPVAAKISNQRHMRAVRAGIIATLPLTIVGSF
                     FTILLNIPIDAYMDFIAPFKAILDIPFRYTVGFLSLYATFGIASSLAKSYDLDTTGVG
                     MLAVMAFLVSTIVPTQVVEPVGGVIEAGRWMDMAKLNSPSLFGAIVTSLITVEIYRFM
                     KEKNITIKMPAGVPVEVSNSFTALLPTAVILMLFWVIRHILGFDISVALSAMLSPLKG
                     FLSGNSLGGGLLTVFLITLFWVLGIHGPAIMGPVIRPIWDMSIAENITAFTEGVSAHA
                     MPNIFTEQFLQWYVWIGGAGATLALVVMFMFSKSQYLKSLGRLGFLPGLFNINEPIIF
                     GAPIVMNPILGIPFIIGPIIMTILSYVLTITGVIPMMVARLPFAMPAPIAAVMSTNWS
                     ILAGILVLINFVISFAVYYPFFKVFEKQQLQREQEEMSENL"
     gene            complement(104124..104825)
                     /locus_tag="KNP36_000098"
     CDS             complement(104124..104825)
                     /locus_tag="KNP36_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0872001.1"
                     /translation="MLRNQPLYIQVVDILKQKILNNEYKIDENIPTERELEQEFGVSK
                     ITIRKAIEILESEGYVEKKSGKGTKVISNSLFNKLSKAESFSSILLSKGHKLSKETIS
                     IEKIINDTNSQVFSIFGEKCSKITRMYYLDSKPYIFFTHYIPFDENLTVESFNNESSL
                     YMYLYRRNINITRFEDEFFIEESELEVSKALNLAKDILLGRKRKTYDENDNIVELSFA
                     RYNTEVQNYVIKYEI"
     gene            complement(105038..105355)
                     /locus_tag="KNP36_000099"
     CDS             complement(105038..105355)
                     /locus_tag="KNP36_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBF0872002.1"
                     /translation="MDEKTIEISFNIIGYAGEGKGLAFEAIKEAKNGNIEKAKELLKE
                     SREVINKAHRYQTELIQNEASGNRTEISVILIHAQDHLMNGMNFQQLAEEIVDLHLKL
                     QDK"
     gene            complement(105403..105714)
                     /locus_tag="KNP36_000100"
     CDS             complement(105403..105714)
                     /locus_tag="KNP36_000100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872003.1"
                     /translation="MIKIMLACSAGMSTSLLVTKMESAAKENGIESQIWAIPESTIQN
                     EIEKCDVLLLGPQVRYVLPKAQEIAKPYNIPVEVINMMHYGTVNGEAVLNRAIELNNT
                     K"
     gene            complement(105863..106342)
                     /gene="rlmH"
                     /locus_tag="KNP36_000101"
     CDS             complement(105863..106342)
                     /gene="rlmH"
                     /locus_tag="KNP36_000101"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HBF0872004.1"
                     /translation="MNISIVVVGKIKEKYLKLGIDEFKKRLSKYCKLEIIELDDEKAP
                     ENLSVKEMEIIKDKEGKKILGKIKHNSYVIALAIDGKGLSSEELAKTMSDLAVRGNSS
                     LCFIIGGSLGLSDEVLGRADYRLSFSKMTFPHQMMRLILLEQIYRAYRINNGEPYHK"
     gene            complement(106410..108512)
                     /locus_tag="KNP36_000102"
     CDS             complement(106410..108512)
                     /locus_tag="KNP36_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC/EAL
                     domain-containing protein"
                     /protein_id="HBF0872005.1"
                     /translation="MLKRNFENVEDNKILYSIKQGMILAIPAIMTGSTALVILNLPIK
                     AYQEYLSGLFNGEVTNILNFINDSTLGIISLIILLTISYSYGKIYGSKYTVLVPIVAM
                     CSFLVFSHGNELNSYIEIFKTKWLFTSIIVSMTSSVLFVKLTESFVTSVKFHTEGADA
                     DFNMVVSAIVPFIIVVFLFSIFRVVMISLIGSSNFQDIFYNLFSNVFNKMGTNLMSAL
                     LFIFLMHFMWFFGIHGSNVLDTVAKNLFENSMAININLVNNNQLPTEIFTKTFFDTMV
                     LLGGCGSLLCLVIAIFLSEKRINVRKLAKIASIPALFNINEMLVFGIPIVFNYIMFVP
                     FVITPIILTVTSYVAMSTGIVPCTVSAVEWTSPIFLSGYMSTGSIRGSLLQVFNLCVG
                     VMIYIPFIKMSQNRYTYMFKNNIENLTNLLKRYELTGEQPNLLNHNGKIGSISKMLAS
                     DLKFAMKRGEIELFYQPQVNYNGNVVGAEGLLRWKHSIGGFIYPPLVIILAKEEGFLD
                     ELGEYIINKACIDLKKSEKLLRNPVKFSVNISPDQLDDPKLPEQIKNIISSNDINPNM
                     LGIEITEQIALSGSQIIIERINAIHNLGIKLIMDDFGMGHSSLIYLQNNNFDIVKLDG
                     SLVKEILTNKRSSEIIMTIVNLSKNLDFDIVVEYVENIDQRDKLYGLGCEIYQGYYYS
                     KAIPFEEFVEYANQEREI"
     gene            complement(108525..109322)
                     /locus_tag="KNP36_000103"
     CDS             complement(108525..109322)
                     /locus_tag="KNP36_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0872006.1"
                     /translation="MLKYCSVGSGSSGNCHYIGYKNTNILVDAGLSGKRITTGLKDIG
                     VDADKLKGIFITHEHVDHIKGAGILSRKFDIPVFANIKTWCSMKDKLGDIKDKNMKVF
                     ENDKTYSLGDIIVRPFSIEHDASDPVGYNFYTESDEKMSIATDIGCITQNIKKHLYKS
                     KLVVLESNYDPNMLMMGSYTYALKKRVMSSTGHLSNEDAANFCVELINEGTESILLAH
                     LSKENNFPELAYETSKGVLASNDIVVGQDVKLDVLSRNDVSNVYEMK"
     gene            complement(109424..110887)
                     /locus_tag="KNP36_000104"
     CDS             complement(109424..110887)
                     /locus_tag="KNP36_000104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HBF0872007.1"
                     /translation="MVIKFNQKVRRTLSVAILFMVLIIGCFIEKDDSLETYKEKTNSK
                     INQYNMDVIFDDETKRLMCNQNVDYINNTKSNIDKIYFHIYPNAFSKKDFAPFEKSEM
                     TRAYPNGFNEGYIDIKNILNNNSKMEYKIKGDKNDILEIELGKELKPNERMSLDIKYN
                     VKIPNSIGRFGYGENTINVTNWFPIACVNDERGWNLKSYETIGDPFYSETSDFHVKLL
                     IPNKYKIAHTGKLIDDKHDNKKMLYEIEAENVRDFAFILSSKFDVNKVDSKGVAINTY
                     NLNKKLSKKATEVAKDSINIFSELFGKYPYKEFSVVASDFFIGGMEYPMLVMIDQSLY
                     NEKNEFLLEYVIAHETAHQWWYSAVGNDEISEPWLDEALTEYSTIVYFEQKYGKDMAN
                     KLIKTMEIQTKSYLSENIFKPANEYKNSTEYSLNVYTKGAIAFNEIRKEVGDKVFFET
                     LNEYYNKYKHKNANGRAFVELWNSKGVDINKIISECK"
     gene            111012..112070
                     /locus_tag="KNP36_000105"
     CDS             111012..112070
                     /locus_tag="KNP36_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HBF0872008.1"
                     /translation="MFFKESNEIDLGEITIPNIFIDIFMPMADGLYVKVYLLGYRQAC
                     DITSNPKFDNNSIAKNLNIPLSDVLSAWKFWEEKKIIKIHDNEEYDNFNYSIEFLDLK
                     NFYIENILSNNSSIKSNTDKVVSTSENPSIRKMFNSINKIVGRYLDPSEKMSIMDIMN
                     KYNMSPDMILCAYEYVKDKTGTSKPVKYIEGIIRNWYDSNLYTPKDVEESFLVRSERY
                     ILYKTIFNELGFSRQPSKSEKELMDTWFDKFNMDIDLIINACSKSKNISNPSISYING
                     IIKNWNEKNIKNLNDLKQKEEERIVKENINKKQINTTQNNNTYKKTKFHNFNETFTQY
                     TSDELDEIIKKSQKEKFK"
     gene            112079..113071
                     /locus_tag="KNP36_000106"
     CDS             112079..113071
                     /locus_tag="KNP36_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872009.1"
                     /translation="MNEDKIRKILAKYAKRRDDNELLLEHRKNEVYNRIPEIKSIDDE
                     ISKIGLSLAKIVLLNPKSKDEIVKKTKENIESLKVKKERLLAESNIPLDYLEIKFQCI
                     SCKDKGFLPNGEKCSCLKQEIVNEAYKMSNLDRILSQENFSNFNLNIFSPKKGSDGEI
                     SPRENMLNNLSICENFVHDFKKDNSENLLFYGSTGLGKTYMCNCIAKELLDKGNVVIY
                     QTSFRILDILEDYKFRRDTNNQISEDNYKNLFDCDLLIIDDLGTELNNSFTSGEIFNI
                     VNTRLVAGKKIIISTNLTPSQIGNTYTQRTLSRILDKFRILEFTGDDLRWERFK"
     gene            complement(113454..113528)
                     /locus_tag="KNP36_000107"
     tRNA            complement(113454..113528)
                     /locus_tag="KNP36_000107"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(113494..113496),aa:Thr,seq:tgt)
     gene            complement(113562..113637)
                     /locus_tag="KNP36_000108"
     tRNA            complement(113562..113637)
                     /locus_tag="KNP36_000108"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(113602..113604),aa:Val,seq:tac)
     gene            complement(113642..113716)
                     /locus_tag="KNP36_000109"
     tRNA            complement(113642..113716)
                     /locus_tag="KNP36_000109"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(113681..113683),aa:Glu,seq:ttc)
     gene            complement(113723..113798)
                     /locus_tag="KNP36_000110"
     tRNA            complement(113723..113798)
                     /locus_tag="KNP36_000110"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(113763..113765),aa:Lys,seq:ttt)
     gene            complement(114124..115413)
                     /locus_tag="KNP36_000111"
     CDS             complement(114124..115413)
                     /locus_tag="KNP36_000111"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HBF0872010.1"
                     /translation="MKTVAIVGSQWGDEGKGKVIDYLATQADVVVRGQGGNNAGHTLV
                     VEGKKYALHLIPSGVLNPNTVNIIGNGIVFDPKGFLEELEMFKTDNISTENIKISDRA
                     HVIFPYHKELDALSEEARGDLKIGTTKKGIGPCYMDKTERSGIRICDLMDKDKFAIKL
                     KAQIDAKNEIVKNIYGKEELFDFETIYNEYLGYAEQIRKYVADTSVIVYDAVRAGKKV
                     LFEGAQGTLLDLDLGTYPFVTSSHPTSGGFAIGAGIGPNMIKDVVGIVKAYTTRVGEG
                     PFVTEQINETGDKIREQGHEFGVTTGRPRRCGWFDAVIVKYAARVNGLTSISFMLLDV
                     LTGFDKIKVCTSYKMGDKIITDFPASLDDLAKCEPVYEELDGWNEDITQIDNFDDLPE
                     NAKKYVAKIEELVGVSVDMVSVGPNRAQTIIRRNIFA"
     gene            complement(115495..115803)
                     /locus_tag="KNP36_000112"
     CDS             complement(115495..115803)
                     /locus_tag="KNP36_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011862026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872011.1"
                     /translation="MEKISLKYIYPNIIKVLDEINLFRVIDNNLRESIVVYANNVDNQ
                     YHINMTNTNFGNIINICKLEKLLDVDKFMEKVIKYEKEIIEKEEFSKIEEYMLNIGEY
                     "
     gene            complement(116008..117336)
                     /gene="dnaB"
                     /locus_tag="KNP36_000113"
     CDS             complement(116008..117336)
                     /gene="dnaB"
                     /locus_tag="KNP36_000113"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HBF0872012.1"
                     /translation="MEDMTRIPPHSVESEQSILGSILLDKDAIITVTETIKPDDFYKE
                     AHKIIYECMITLSNKGEPIDLITLTEELRKQGHLNDIGGISYITSLSTIVPTTSNVKY
                     YADIVKEKSVLRKLIKASNEIINLGYSGATKIEDVLEQAEKSIFDISQEKTSDDFKSI
                     NLVLMDAYDMIEKLYTNKSDVTGITTGFKDLNKKINGLQRTDLILIAARPAMGKTAFS
                     LNLVQNAALKGDASVAVFSLEMSKEQLVQRMLSSQSSVELKKIKTGTLNDNDWPRIID
                     AMAVLSDAKIHIDDTPGIKISELRSKCRKLKIEKGLDLVLIDYLQLMEGEGNNESRQQ
                     EISKISRSLKILAKELNCPVVALSQLSRAPEQRADHRPMLSDLRESGAIEQDADIVMF
                     LYRDEYYHADSESKNIGEVIIAKNRHGETGSVELVWLGEVQRFGDKLRDL"
     gene            complement(117355..117804)
                     /locus_tag="KNP36_000114"
     CDS             complement(117355..117804)
                     /locus_tag="KNP36_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HBF0872013.1"
                     /translation="MKVILLKDVKGTGKKGEMKEVSDGYARNFLFPKKMAVQADSVAI
                     KELNEKNKSKEIKAQKEYEEAVLLGKQMEEINIEIYSKAGEGGRLFGSITSKEIAEQL
                     KKQKDIDVDKRKILLDEPIRSLGSTFVEIKIHQKVTTKIRVDVKEKQ"
     gene            complement(117805..119799)
                     /locus_tag="KNP36_000115"
     CDS             complement(117805..119799)
                     /locus_tag="KNP36_000115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HBF0872014.1"
                     /translation="MSNKQTFKLNMPEINLYIIVIGISSIILLYYNLYVGCLFFCIFV
                     YMVFHNWRTTNIRRHEWTEYIQNLSLDIDETTKKAIINLPIPLCILEFDGNISWYNGK
                     FYDMIGQKDLLDKNIEDIVKNLNLRKVLNENKEMYTEINYKEKEYTIIYNVIKNDQEK
                     NPKYLMILYWIDKTEYLKVKQNYDDEKNAMMLIQVDGYDEVLKSAAEDKRALINVEVE
                     KILSALELNSNGALRRTSKDKFFLVMHKKELKKLEAEKFSILDTIRHIDYGNNLPVTI
                     SIGIGIDGDTLNENLKLATGALDLALGRGGDQAVVKTKDKFVFYGGKSKAVEKKTKVK
                     SRLIGHALREVIQQSDQVYIMGHKYPDMDAMGAAVGVYDICKSCNKTANIVLQSVNES
                     IEIFINKINENNYYKKLFIGKEEAIDNCTKNTLVVVVDTHRPNYTECEELLKLSEKVV
                     VIDHHRRGVEFINDAVLLFHEIYVSSTCEMVTELVQYMDEDVTINKLTAEGLLAGISL
                     DTKNFAFKTGVRTFEAASYLRKVGADTIEVKKFFNSDVKDFIIKAEIIQSTKIINNRI
                     CLAYSSTEIDSINVIIAQTADELLNIKEVEASFVLGEKDDTIFISARSLGQINVHVLM
                     EKLGGGGHIDIAGAQLKNVSLKEAYKMVNKIIEEYLEEEE"
     gene            complement(119810..120766)
                     /locus_tag="KNP36_000116"
     CDS             complement(119810..120766)
                     /locus_tag="KNP36_000116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YybS family protein"
                     /protein_id="HBF0872015.1"
                     /translation="MNNKIRLSKAMSIIVLAIIIALVIAYIPMLGIFSMLAAVPYVII
                     GAITDRKYSLISILVTFCVLILFADISYALNICIMYSLPGIVIGKMLKRSFEQEDSNK
                     FEPIYGGTIIFVLSMLVYFFVLKTFLNVNLLDEVSKMISEIVNIQKNSFSATELKVFD
                     KMKPDEIVSYFTNMLPMMLFLQGLLSAFVTYYLSVFFIKRITKMNIRFPKFADFYLPG
                     NAILTTFLLYLLVLFIQIIGSKLYTELIMTNLQLVFNLMFVIQGIAVCIYFLKKWIRQ
                     GPNKIMFFSGIILCLFGFMGISFVGMVDSIIDFRKVRSYKST"
     gene            complement(120774..121094)
                     /locus_tag="KNP36_000117"
     CDS             complement(120774..121094)
                     /locus_tag="KNP36_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like family protein"
                     /protein_id="HBF0872016.1"
                     /translation="MKIDKGSEITRNIKIIEWMKTEILMSVSDLFNLLFKGVKPLDEA
                     IQDTLANIIMITYLLAKRLGISFRDVDYKVKEKIKIGIDEDHSVERWYGDLSNLKKHM
                     DNRE"
     gene            complement(121237..121464)
                     /locus_tag="KNP36_000118"
     CDS             complement(121237..121464)
                     /locus_tag="KNP36_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HBF0872017.1"
                     /translation="MMNKKRRKKKRVCQFCADKNAKIDYKSTQRLQKYITERGKILPR
                     RISGTCAKHQRELTVAIKRARNIALLPYTLD"
     gene            complement(121483..121917)
                     /gene="ssb"
                     /locus_tag="KNP36_000119"
     CDS             complement(121483..121917)
                     /gene="ssb"
                     /locus_tag="KNP36_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBF0872018.1"
                     /translation="MNQVVLVGRLTRDPELRYIPGTGTPVASFTIAIDRDYVKKDGSK
                     ETDFIPVEVMGKSAEFCANYITKGRLVALQGSIRVDNYQTQSGEKRTFTKVSTRSVQA
                     LDSKNKSENSYRESAPAFEPSFEPQGLDPQGFQAIDDDDIPF"
     gene            complement(121954..122232)
                     /locus_tag="KNP36_000120"
     CDS             complement(121954..122232)
                     /locus_tag="KNP36_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HBF0872019.1"
                     /translation="MRNYELVYVVKPNSDEEVREAILNKVKEVVATDGEIVKVDTWGT
                     KKLAYPIAKFTEGFYVLVNFKSAVDVPKEIDRNLKINENVIRHMIVVA"
     gene            complement(122446..123642)
                     /locus_tag="KNP36_000121"
     CDS             complement(122446..123642)
                     /locus_tag="KNP36_000121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0872020.1"
                     /translation="MAVKYAKRMQGLQGSEIRELLKLTQQPQIISFAGGMPAPELFPV
                     EEMKKVSVAVLEENGRSAMQYTTTEGYEPLREKIAARMNDKNKTNVNKDDILVTSGSQ
                     QGLDFAGKVFIDEGDVILCESPSYIGAINAFKSYQPKFIDVPTDSDGMIMEELEKILE
                     TTDRIKMIYVIPDFQNPTGRTWPLERRKKFMEIVNKFEIPVIEDNPYGDLRFEGETLP
                     SLKSMDTKGLVIFLGTFSKIFCPGYRLGWTCASPEILSKFNFAKQGADLQASTISQME
                     VSKFMDMYDLDAHVDKIKAVYVKRRDVMLKTMEEEFPEGLVFTHPEGGLFTWVELPSN
                     LNAKELMPKCLDKNVAYVAGGGFFPNGGRENTFRLNYSNMPEEKIIEGIKNIAAVLKE
                     AMGVEA"
     gene            complement(123745..123930)
                     /locus_tag="KNP36_000122"
     CDS             complement(123745..123930)
                     /locus_tag="KNP36_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 domain-containing protein"
                     /protein_id="HBF0872021.1"
                     /translation="MPMDLKIGDIVELKKQHACGCKEFEIIRTGMDIKIKCTKCSRLI
                     MLDRETLEKRVKKLIKK"
     gene            complement(123945..124208)
                     /locus_tag="KNP36_000123"
     CDS             complement(123945..124208)
                     /locus_tag="KNP36_000123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3343 domain-containing protein"
                     /protein_id="HBF0872022.1"
                     /translation="MNQMYIVSFNSTHHAIRSEKLFGENSLKVMALPTPREITASCGI
                     SIKFSFEDMEKIKTILVENNVDIKGIYCISKLENGSKEVEKLD"
     gene            complement(124281..124883)
                     /gene="yedF"
                     /locus_tag="KNP36_000124"
     CDS             complement(124281..124883)
                     /gene="yedF"
                     /locus_tag="KNP36_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfurtransferase-like selenium metabolism
                     protein YedF"
                     /protein_id="HBF0872023.1"
                     /translation="MSIKIDARGLACPKPVINTKRELDNLEEGVVVTIVDNETAKENI
                     LKLAKSLSCEANIVDEKENFISIEIRKGKNILDKQNVVDNKESELDNTCIFISSDKMG
                     LGNDELGKVLIKGFIYTLTESKPYPKYVLLVNGGVKLSAENEETIENLKILENMGVEV
                     LSCGTCLDYYNLKDKLQVGTVTNMYTIVETLKNASNTISI"
     gene            complement(124988..126280)
                     /locus_tag="KNP36_000125"
     CDS             complement(124988..126280)
                     /locus_tag="KNP36_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBF0872024.1"
                     /translation="MEILSLGEKIKKLRKEKNMTLKELAGDRITAAQISHIERDKSHT
                     SYELLEYLGDKLDVSVEYLLETKEMQSKKITDNLILQSEIYIKENELNKAEDQIKEVL
                     DICKRYDLMENYGRCNFLMANINLKKSNYNDAIENFEKALYFFIKNSDSENILKCYLN
                     IGKIYMQEDFYKGAISHFNFAEEILSENKFEDVNIHKELYSKMAYCYIKLDNPNMSLK
                     YIEKINEIDNRNDRKEDVDILVLKANNMLEIGKYEESRDYFKKALKILESEDNKTGLA
                     NVYLTICDVYRKIGETDRVLEYSQKVYDIKKNDEDEYMMSGLFKIIEAYIDKEDYDLA
                     RKYCKIALASSIKNKNKFNEYKALRFYANMYKNQNEVTLAIEYLIKCIKIVSDLGNNR
                     ILANLYIDLGQLYSNISKEKELEYYQKGVFMYKNLEIM"
     gene            126540..127115
                     /locus_tag="KNP36_000126"
     CDS             126540..127115
                     /locus_tag="KNP36_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GerMN domain-containing protein"
                     /protein_id="HBF0872025.1"
                     /translation="MKNKKIMLVLSILSISIFAVGCTNAQNGSDSSKKETKSNTNVEQ
                     PKEENNTEKEVPNNKAKPTPKEETKTQSATIYSFDVDKTDLIENKVDLNKIDENTLFE
                     ELQKLKVVPESAKLNSFTTKDIDGVKTGILDVSSDFTKSNLGSDAETLMLDSVARTYI
                     KNMNVEQIKITVDGSNYESGHIVLEEGDYLK"
     gene            complement(127249..128391)
                     /locus_tag="KNP36_000127"
     CDS             complement(127249..128391)
                     /locus_tag="KNP36_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBF0872026.1"
                     /translation="MIYLDNAATTYPKPERVYNAVLDCMKNYCANPGRAGHKLAMRAA
                     REIYDTRENIAKLFNVSNPMNIVFTSNATDSLNLAIKGVLQEGDHVITTSMEHNSVIR
                     PIKALEKRGIENTVVKCDYEGFLDYEDLEKSIKSNTKLIVTTHASNVCGTLIDIKKVG
                     EIAKKHNILFLVDASQTAGVYDIDVNECNIDMLAMPGHKCLFGPQGTGILYVREGLNL
                     NILKEGGTGSKSEEIVQPELFPDKYESGTHNTPGIAGLNQGILFIFERGINNIRQHEE
                     ELCQYMIDKLEEVPDIKIYGPKDSKKRASVIALNIGDMDSGEVTFLLDSDYNIATRSG
                     IHCSPLAHTTLGTLKQGAVRFSIGYFNTKDEIDKAVEALKKISKNK"
     gene            complement(128424..129287)
                     /locus_tag="KNP36_000128"
     CDS             complement(128424..129287)
                     /locus_tag="KNP36_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HBF0872027.1"
                     /translation="MENKSKRSNRLGRGLSALIPEIKGETSEKEIVNIDIDKIYPNEV
                     QPRKQFDEEKIKVLSDSIKNYGVLQPIVVKMDENNKYMIIAGERRFRASKLANKNQIP
                     AIIKDIDMKDIMEIALIENLQREDLNSIEEALAYKSLIEHYNVTQEEISEAVGKSRPH
                     ITNTLRLLNLGQDVIEMIDSGRITAGHGKALLRIADKDLQLQIAKKIEEEELSVREVE
                     NIAKKISENKQEEPKKSKPKDVFILDVEDKLRNIFGTKVNISKGKKKGKIEIEYYNDD
                     DLNSIVSMLLE"
     gene            complement(129289..130062)
                     /locus_tag="KNP36_000129"
     CDS             complement(129289..130062)
                     /locus_tag="KNP36_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="HBF0872028.1"
                     /translation="MGKVIAVFNQKGGVGKTTTNVNLSASLGTLGKKILVLDLDPQGN
                     TTSGYGINKNEVENTIYEIMLDGLHIKEAIISTEFENVDVVPSATELSGAEIELTSKT
                     NREYILKNSIKAVIDEYDYIFLDCPPSLGMLTINCLTAVDSVLIPIQCEYYALEGVSQ
                     LMETIKLVKSRLNADIEIQGVVLSMFDGRANLSIQVVEEVKKYFKGSVYTTLIPRNVR
                     LAEAPSHGKPVIYYDKRCRGSVAYLELAEEFIDLEEEEW"
     gene            complement(130197..130982)
                     /gene="noc"
                     /locus_tag="KNP36_000130"
     CDS             complement(130197..130982)
                     /gene="noc"
                     /locus_tag="KNP36_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid occlusion protein"
                     /protein_id="HBF0872029.1"
                     /translation="MEDKRVMEIPIEDVVPNPYQPRKIFSQVSLEELSNSIKVYGIIQ
                     PITVRAKDGKYELIAGERRLRAAKLAELKTIPAIINNMNDESSAVLALLENLQREDLN
                     FIEEAIGYENLIKEHAFTQQQLAEKLGKNQSTVANKLRILKLPNDIKMKLIENNLTER
                     HARAFLKLPSEDLMQSVLDKVIKNELTVKKTEKLIQDVLEETKVQEEPDKKQNIKGAM
                     SIRIYINTIKQAFDAISNTGIDAKYNEIDKGDYMEVVVKIPKK"
     gene            complement(131145..131864)
                     /gene="rsmG"
                     /locus_tag="KNP36_000131"
     CDS             complement(131145..131864)
                     /gene="rsmG"
                     /locus_tag="KNP36_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HBF0872030.1"
                     /translation="MNNIELLKNGIEGFNIDTNDSMLEKFKIYREILVDWNKKMNLTG
                     IEDEKEVYIKHFLDSISAVKNGYIKNGMSIIDVGTGAGFPGIPLKICLDSLELTLLDS
                     LNKRINFLEEVSRVLELDNITFIHGRAEDFGKDEDYREKYDVATARAVAGLPILMEFC
                     VPFVKVGGYFICLKGPNANLELEESQKAIDVLGLEYIEKIDVELPEVDLNHNILVFKK
                     VMETPVKYPRKAGKPAKNPIK"
     gene            complement(131857..133749)
                     /gene="mnmG"
                     /locus_tag="KNP36_000132"
     CDS             complement(131857..133749)
                     /gene="mnmG"
                     /locus_tag="KNP36_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012065747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HBF0872031.1"
                     /translation="MKFEAGKYDVIVVGAGHAGCEAALATARMGYKTLIITMSLDSIA
                     LMPCNPSIGGTGKGQLVKEIDALGGQMGLNIDKTYIQSRMLNTAKGPAVHSLRAQADK
                     FKYHEEMKKTLEDEPNLDIAMDEVVEILHEGNVVIGVGTKLGCSFKSKAVILATGVYL
                     NSKIYMGEVAFYEGPNALGYAKYLTDSLVELGLRMRRFKTGTPARVHRDSIDFSVMSL
                     QEGDEKVTPFSFMNENIEKKQEPCYLTRTTEETQKVILDNLKRSAMYSGVIESTGPRY
                     CPSIEDKVVRFSDKTSHQLFIEPEGLNTKEMYIQGISTSLPFEVQLDMYKTIKGLENC
                     KIMRPAYAIEYDCVDPTQLKISLEIKGVENLFSAGQFNGTSGYEEAAAQGLMAGINAV
                     RKIEGKEPFVLDRSEAYIGVLLDDLVTKGTNEPYRMMTSRAEYRLYLRQDNADMRLTQ
                     KGYDIGLVKKDRYERFLNKKAAVEKEFERLKNERVTPKEVNSLLEEKGATPIKVGISL
                     YEFLKRPEVTYELLEELGKGAGEDVSREVKEQCVIITKYEGYIEKQLKQIDQFKKLEN
                     KKLDEKINYSSIEGLRLEARQKLDDIKPISIGQASRISGVSPADISVLLIYLEQIRRT
                     RGGKGE"
     gene            complement(133847..135226)
                     /gene="mnmE"
                     /locus_tag="KNP36_000133"
     CDS             complement(133847..135226)
                     /gene="mnmE"
                     /locus_tag="KNP36_000133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HBF0872032.1"
                     /translation="MFIDDTIAAIATAPGEGGIGILRISGEKALKVAEEIFKSMSGKS
                     IEEYNKRTLIYGNIVDNENIIDEVLLAYMKGPNSYTGEDVIEINCHGGFISVKKILEL
                     ILSKDVRLAEAGEFTKRAFLNGRIDLSQAEAVIDVIKAKTDIAHEVAQNQLEGSLSKK
                     IRELRDKVTEILAHVEVAIDYPEEDIEHITYQTLKEKTDELKKDIKKLYDTAESGKIL
                     REGLKTVIVGKPNVGKSSLLNSILGENRAIVTDIPGTTRDVIEEFVNIKGIPLKIVDT
                     AGIRDTDDIVEKIGVEKSKESFTSADLIVMVLDASRKLSEEDIEILEKLKDKQTIVLL
                     NKNDLKQEIEEEKILKYVENNSIIKISALQQEGIEELQDKIESMVYKGSIKNNSSLVV
                     TNSRHKDALSKAYKSATDALIALEQSMPFDFVEVDLKNIWDYLGYINGDTVTEDLLDN
                     IFHNFCIGK"
     gene            complement(135338..135967)
                     /locus_tag="KNP36_000134"
     CDS             complement(135338..135967)
                     /locus_tag="KNP36_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HBF0872033.1"
                     /translation="MRKSLKLIKSKSKEEAISKAIAELNLKAEDIEVEILENPSKGFL
                     GFIGAKDGTYEIFVIEREVDVAKNFIEVMLKNANVDAKVNVSQKDNLIMVDIEGKEAA
                     SLIGRRGETLDSIQFLTGLALNKINKDSHTRVLVDIENYRSKREESLIRYANKVAREV
                     AKTRKTKKLDYMNPYERRIIHSALQNDKYVITYSEGTDPYRRLVIECKR"
     gene            complement(135936..136643)
                     /locus_tag="KNP36_000135"
     CDS             complement(135936..136643)
                     /locus_tag="KNP36_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HBF0872034.1"
                     /translation="MNIIGNFLGLILKVIFEFVNHYGISIILFTILVKIILLPLTIKQ
                     TKSTKAMQDIQPRIKEIQEKYKNKPEKQNEEIVKLYGEAKINPLSGCLPLLIQFPILI
                     GLFSVLREPVAHGVFANKAAFLAADNGFLWIKSLTSPDYVLAVFSGASAYVMQKVMTP
                     KDQLQGSMKVMTYVMAGMSFYWGFIFPAGLTLYWTVSNLFSIAQYYLIMNPLKAKLAA
                     NSKEEKVNEKKPKINKK"
     gene            complement(136675..136926)
                     /gene="yidD"
                     /locus_tag="KNP36_000136"
     CDS             complement(136675..136926)
                     /gene="yidD"
                     /locus_tag="KNP36_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HBF0872035.1"
                     /translation="MNKIIYILKEISKYLSNLCIYLVRFYQKYISPLKGPTCRFYPTC
                     SQYSIEAFKKYGFVKGMYLTIRRILKCHPFHPGGYDPLK"
     gene            complement(136958..137302)
                     /gene="rnpA"
                     /locus_tag="KNP36_000137"
     CDS             complement(136958..137302)
                     /gene="rnpA"
                     /locus_tag="KNP36_000137"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HBF0872036.1"
                     /translation="MDFNRTKGLKKDSDFRKVYKHGKSFANKYLVIYILKNKSDYSRV
                     GISVSKKVGKAITRNRVRRLIKEAYRLNIDEKIKPGYDIVFIARVSSKDATFKDIDKS
                     IKNLVKRTDISI"
     gene            complement(137380..137517)
                     /gene="rpmH"
                     /locus_tag="KNP36_000138"
     CDS             complement(137380..137517)
                     /gene="rpmH"
                     /locus_tag="KNP36_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HBF0872037.1"
                     /translation="MSKRTYQPKKRQRSKEHGFRKRMKTSNGRNVLKRRRAKGRNRLT
                     H"
     gene            138173..139495
                     /gene="dnaA"
                     /locus_tag="KNP36_000139"
     CDS             138173..139495
                     /gene="dnaA"
                     /locus_tag="KNP36_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HBF0872038.1"
                     /translation="MMDIVSLWDKTLQLIKGDLTSVSFNTFFKNIVPLKIHLNDLILL
                     APSDFNKDILENRYLHLIEDAISQLSLKKYNIKFVLSEKEVADLNSDSTDLNYRVLYP
                     NLNPKYTFDTFVIGNSNRFAHAACVAVAESPAKAYNPLFLYGGVGLGKTHLMHAIGHH
                     IVSQKKDSKVVYVSSEKFTNELINSIKDDKNEEFRNKYRNVDVLLIDDIQFIAGKERT
                     QEEFFHTFNTLHEANKQIIISSDRPPKDIPTLEDRLRSRFEMGLITDIQAPDFETRIA
                     ILRKKAQLERIDVPNEVMSYIAKNIKSNIRELEGALTRVVAYSSLSNRVISFDLATEA
                     LKDIITTSKNEEINVLRIKEKVSSVFNLKMEDFNSKKRTRSIAYPRQIAMYLTRELTD
                     LSLPKIGEEFGGRDHTTVIHAHDKVSKDIEESEEIKTKIDKIISDLKG"
     gene            139737..140843
                     /locus_tag="KNP36_000140"
     CDS             139737..140843
                     /locus_tag="KNP36_000140"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HBF0872039.1"
                     /translation="MKIICNQKILANRIGIAQKAINGKTTIELLKGILISTEEGQLKL
                     TGYDAEIGIETYVQAEIIEKGDVVVDARLFGDIIRKLPDSFVEIETDSENNIYINCVN
                     SRFKIKGYAAKEFPKLPELNEEDLYSIPQEILKNMIKQTVFAISQDQTKPVLMGELLE
                     IVDRNLNLVAIDGYRLAVKSCSVDSLTENIKVIIPGKTLIDVNSLLSGEDNVKVGFNE
                     KNAIFIINDTKIITRLLEGDFIDYKKLLPREHNSRVKLNTKELLNSIERASLLSQSEK
                     NNLIKLSIRDKVMAITSNTEKGNVYEEVEIDLDGDYLDIAFNSRYFIEGLKNIDNEEI
                     FIEFTTNVNPCIIKPTDDVNYIYLLLPVRISSNI"
     gene            140980..141186
                     /gene="yaaA"
                     /locus_tag="KNP36_000141"
     CDS             140980..141186
                     /gene="yaaA"
                     /locus_tag="KNP36_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HBF0872040.1"
                     /translation="MTEITIESEYIKLDQFLKLAEIASTGGHAKFLIQEGLVTVNDEI
                     ELRRGKKIKSGDIVEIEGTKIKVL"
     gene            141204..142319
                     /gene="recF"
                     /locus_tag="KNP36_000142"
     CDS             141204..142319
                     /gene="recF"
                     /locus_tag="KNP36_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HBF0872041.1"
                     /translation="MKLKSLQLVNFRNYKKLHLEFNGKVNLLVGKNGQGKTNIVESIY
                     MLSFGKSFRTNKDKEMVRFNSENLYIGGSFSKYNKYSLIELIIGKDKKGIRINKVPLQ
                     KIQELLGNLNVVIFSPEDLRLVKEGPKERRAFIDKEISQIIPKYYKYLTNYNKTLSQR
                     SRVLKNIHVDEALLDVYDDTLAKYGSYIYILRRDFIKKIANISENMHMNLTNGVERLS
                     IRYKNQINITDEDTIDTVYNKFLAKLSSNRPNDIESKTTRYGIHKDDLNIFINDLDAR
                     LFGSQGQQRTASISLKLSEIELIKNEVEEYPVLILDDVFSELDEARQKLLVNNLSNVQ
                     MFITSAEVSHKKIFDEKNVTIFNIENGDVISIENGGN"
     gene            142320..144221
                     /gene="gyrB"
                     /locus_tag="KNP36_000143"
     CDS             142320..144221
                     /gene="gyrB"
                     /locus_tag="KNP36_000143"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003226808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HBF0872042.1"
                     /translation="MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVD
                     NSIDEALQGYCSDIYVSINEDGSVLVKDNGRGIPVEIHPKTGKSTLETVLTNLHAGGK
                     FGGGGYKVSGGLHGVGVSVVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQ
                     DKGTMIQFMPDETIFDEIEFKYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHY
                     TGGLVEYIKYLNKSRTGIHDDIVYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTH
                     EGGSHLSGFKAALTKTVNDYAKRNKFLKENDVNLLGEDIREGLTAVVSVKLPEPQFEG
                     QTKTKLGNSFMRGIVDSVTVDELGSFLEENPSTARIIVDKALRAQRAREAAKKARELT
                     RRKSVLESTSLPGKLADCAEKDPSKSEIFLVEGDSAGGSAKQGRDRNSQAILPLRGKI
                     LNVEKSRLDRILSSDEIKNMITAYGCGIGEDFDIDKARYHKIIIMTDADVDGAHIRTL
                     LLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQKKEHYVYSDKELNILLDEIGRNGVELQ
                     RYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAAIADEVFSMLMGDKVAPRKEFIEEN
                     ARFVRNLDI"
     gene            144241..146667
                     /gene="gyrA"
                     /locus_tag="KNP36_000144"
     CDS             144241..146667
                     /gene="gyrA"
                     /locus_tag="KNP36_000144"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HBF0872043.1"
                     /translation="MEENNKILPIEIAEEMKKSYIDYSMSVIAGRALPDVRDGLKPVH
                     RRILYSMSELNLTPDKPYRKSARIVGDVLGKYHPHGDTAVYYAMVRMAQDFSTRALLV
                     DGHGNFGSVDGDSPAAMRYTEAKMSKLSLELLRDIEKETVDFKPNFDESLKEPSVLPA
                     RYPNLLVNGSNGIAVGMATSIPPHNLAEVIDATVYLIDNPECSVDDLIKFVQGPDFPT
                     AAIIMGKESIAEAYRTGRGKVKVRSRAFIEELPKGKQQIIVTEIPYQVNKAKLVERIA
                     ELVKEKRIEGISDLRDESNRNGMRIVIELKRDANANIVLNNLYKHSQMEDTFSIIMLA
                     LVDGQPRVLNLKQILYHYIKHQEDVVTRRTKFELNKAEARAHILEGLKIALDNIDAVI
                     SLIRASKTGQEAKLGLIEKFKLTEIQAQAILDMRLQRLTGLERDKIEAEYEDLIKKIN
                     RLKEILADERLLLNVIKDEITIIKENYSDERRTEIRHAEGEIDMRDLISDEEIAITLT
                     HFGYIKRLPSDTYKSQKRGGRGISALTTREEDFVRHLVTTTTHSRLLFFTNKGRVFKL
                     NAYEIPEGKRQAKGTAIVNLLQLSADEKIATLIPIDGNDENEYLLLATKKGIVKKTKR
                     EEFKNINKSGLIAIGLRDDDELIGVELTDGKQEVLLVTKEGMSIRFDENDIRYMGRTA
                     MGVKGITLSKEDFVVSMNLCSKGTDVLVVSKNGFGKRTNIEEYRSQIRAGKGIKTYNI
                     SEKTGTIVGADMVNEDDEIMIINSDGVLIRIRVNEISLFGRVTSGVKLMKTNDEVNVV
                     SIAKINIEEE"
     gene            146736..147032
                     /locus_tag="KNP36_000145"
     CDS             146736..147032
                     /locus_tag="KNP36_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBF0872044.1"
                     /translation="MCNKRSCKKGGFLLLGAILGFIFGMFFAPKKGSELRKETKEKFN
                     DVKENPKEVLHETFNDVKERIINLVDDDNNEEDIKISEEDIVISKSFDDEGDVN"
     gene            147032..147292
                     /locus_tag="KNP36_000146"
     CDS             147032..147292
                     /locus_tag="KNP36_000146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HBF0872045.1"
                     /translation="MNAWGWQIGAVLVGSSALIVAIYLAKTLNSINKVVEKAYKIVDY
                     NERHIQDIVENASSISKGIDDIVYVINKILSIGNIFKIIKRK"
     gene            147304..147621
                     /locus_tag="KNP36_000147"
     CDS             147304..147621
                     /locus_tag="KNP36_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="STAS domain-containing protein"
                     /protein_id="HBF0872046.1"
                     /translation="MSMNIDSNLDSQNKFWNVCLDGELDVSTADKLKEHLHALIEKNM
                     LDVKINLKDLDYIDSTGLGAMIGVLKKLKINEKEIYIVNPKSNVRKIFTITGLDKIFK
                     VEG"
     gene            147646..148032
                     /locus_tag="KNP36_000148"
     CDS             147646..148032
                     /locus_tag="KNP36_000148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872047.1"
                     /translation="MEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTN
                     AIKHSKDDVFNIVFNILDNAINIEIQDNGKGYDVSSISTPDLENPKESGLGLFIIKTL
                     MDDVDIESEHNQGTKIKMTKYLGVDI"
     gene            148032..148805
                     /locus_tag="KNP36_000149"
     CDS             148032..148805
                     /locus_tag="KNP36_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="HBF0872048.1"
                     /translation="MKNVANATHYLNMDTKELFNLYNKNKNVDIRNILIERHLYLARL
                     LAKKYINKGVDFEDIYQVASLALIYAIDRYDVEKGFEFSSFATPTIVGEIKKYFRDKV
                     WTLRVPRRIQELSKKISDAKIKLEQENKKHPKVKDIADYIGVSEEDVLEAMEASYGYQ
                     PMSLDSSSNDDSEDKDITLIDKIGKEEGNFGSIEYEDFINKFIETLNELEVKIFKDRF
                     FFDKTQSSIAKELGISQMTVSRLEKKVVEKLKKEYEKNL"
BASE COUNT        48312 a        26008 c        16868 g        57688 t
ORIGIN      
        1 tttcgtcaat actttttttg ttttttattt taaaaaaggt tataactttt ggttttttta
       61 ataaatataa ttaaaactaa tagatataac ccttgatatt acaaacaata catgcatata
      121 taattttacc tattttgcaa ttttattttc ataagaatat gaattagctc tcactctatc
      181 tgcccaaaca tttatactct taactttatt aacattagtt gtaccctcaa aaatatccat
      241 tgcatcctta caaaaatata tcataacatc aagaaccaaa aatccaacac aaaataaaca
      301 taaaaaatta attacttgaa acatcagaca ttcccccaat aattttttat atatagtatt
      361 ctcataaatt attcttttta ccttctcata aattattcta aatattttca taataaatta
      421 ctttcaatca tattttctaa atataaagtc tcaatcaaca aaaactaata tcaatttcta
      481 acgtttgttg gtaatttata aattaaatat ctaaaagaat ctttgaagca tataaaaagc
      541 attccacact gacattttaa ataaaattta gctatttatt gataatttaa tagctaaact
      601 ttatttaaaa cttagtagaa tgctaatatt tcttagtttt cttcttcttt atttggattg
      661 ttatcaatag gtttcatagt cgggaataat aatacatctc ttatagatgg agagttagtt
      721 aataacataa ttactctatc tatacctatt cctagtcctc ctgtaggagg tagacctacc
      781 tctaatgctt ttaagaaatc ttcatccatt tcaaaagctt catcatcacc taattctctt
      841 tttctcaatt ggtctataaa tcttcctttt tggtcaatag ggtcattaag ttcagaaaat
      901 gcattagcta actcccactt attagcaaat gcctcaaatc tatcagttct tcttgggtct
      961 tcaacatttc tcttagataa tggagatact tcaactggat ggtgagttat aaatgttggt
     1021 tggattaatt tatcttctcc aaattcttca aagaaagcat ttattacttc tcctcttctc
     1081 attccaggtt ttatctctat acctttttct ctagcaactt ctagtgcctc ttcatctgta
     1141 tttatagtag aaaaatctac accagaatat tctttaacac aatcttccat actcattctt
     1201 ttccaaggtg gtgtaaagtt tatttctgtt ccttgatagt taactatcat acttcctgta
     1261 gcaacttcag ccatatgtgc aataacattt tctgttattt ccatcatatc agtatagtct
     1321 gcatatgctt gatataattc tattgcagta tattcaggat tatgttttaa atccatacct
     1381 tcatttctaa acattcttcc catttcataa actttatcaa atccaccaac aataagtctt
     1441 tttaaataca attcattcgc tattcttaaa tacattggta tatgtaaagt attatgatta
     1501 gttataaatg gtctagcatt tgccccacct gctatagtat ttaatattgg agtctcaact
     1561 tctaaaaatc ctctatcatc taagtatgct cttaatgctt ttaatgcttt tgttctaatt
     1621 aaaaaagcat tttttacttc tggatttact attaagtcaa catatctttg tctatatctt
     1681 agttcttggt cttttaatcc atgatatttt tctggtaaaa cttgtaaaga tttacatagt
     1741 aatactacag atttagcctt tacagatatt tcaccttttt tagttttaaa gatttctcct
     1801 tcaattccaa ctatatctcc aatatcatat gttgaaaata cactatattc ttcctctcct
     1861 atagcatcta gtcttacata agattggatt cttccctctt ggtcttgaat atctataaag
     1921 ccagctttcc cttgtattct cttgctcatt atacgtcctg ctatttttgt agttttaccc
     1981 tcaagagaat caaagttatc ttttatatcc atagaataat gagttctatc atatctactt
     2041 tctttaaaag gatctctacc tgactcttgt aattttttta gtttatctct tcttacttga
     2101 agtacttcac taaggtcttc ttgaatttgc gcttcttcat tgctttgttg attatttttc
     2161 atttttttcc tccaaattat cttcttattt ctaatatttc aaacttagca actccatcag
     2221 gaacttgcac ttccacaact tctttcgcag ctctacctaa aagtgctttc cctacaggag
     2281 attcgtttga tattttacca tcatatgggt ctgcttctgt cgaaccaact atagtatatt
     2341 caacctcttc atcaaattct aaatccttaa ctttaactat tgatcctatt gtaacaacat
     2401 taaggtctat tttgctttca tctatgataa cagcttttct aaccatattt tctaatttta
     2461 aaattctttc ttcaacttgt gcttgttcct ttttagcttc atcatactca gcattttcag
     2521 ataaatcacc aaaagatata gcaactttta ttctctctgc aacttctttt ctctttacaa
     2581 cctttaagtt ttctaattct tcttctaatt tatcatatcc ctcttgtgtc aataaaaact
     2641 ctttattttc ttccattata aatacaactc cttcacaaat ttcttaggaa ttttcctaat
     2701 tatattttaa aaattttata atcttttttt aatttatgcg ctatattata agtcactatt
     2761 atttttatgt caaggagtct tccatatagt actccaattt cgacacaact tcttgatagt
     2821 cttctatttt gttaatttca tcccttaatt ttgcagagtt tctaagtcct tttaaatacc
     2881 aagcgatgtg ttttctcatt tcccttacag ctacatactc tccatgttct tctactgcaa
     2941 gttttaaatg cttaatggca gtacttattt tttcgttaag agttggctct ggcaaaatct
     3001 cgcctgtatt catataatgg tttattcttt taaatatcca agggttacct tgagcacccc
     3061 tacctatcat tatagcatca caaccagttt tgtctaacat atttattgaa tcttctattg
     3121 taaatacatc accatttcct ataacaggta tactcaaatt tttcttaatc tctgcaatta
     3181 tatcccagtc tgctttgcct gtataaaact gttctctagt tcttccatgt attgctaaag
     3241 cacttattcc acaatcctct gctatctttg ctatttcaac agcatttaca ctattatcat
     3301 cccagccttt tcgaatcttt aaagtcactg gcttttttga gttcttcact actgccctca
     3361 atacctcttc tgcaagctta ggatttttca taagtgctga accatctcca tttttaacta
     3421 cttttggagc tggacacccc atatttatat cgagaatctc atttgaataa tcattcatta
     3481 tctctgttgc tcttcccata aactctggtt ctgaaccgaa tatctgaact gctacaggat
     3541 gttcttcctc ttctatctta agcatttttt tagtattttc atcatcatag caaagtgcct
     3601 taccatttat catttctgta tataaaagcc cacatccttg ttctttacaa attaatctaa
     3661 atggaaggtc tgttacacct gccataggtg atagaaaaac tttatttttc aattctaaat
     3721 ttcctatttt cattgttttt ctcctatttt tgcctttatt ttgtgattta actttaaatt
     3781 cttatttcct cattataata taccacatat agctagaaat ctatcataaa aagggaattg
     3841 gatatataac ccaattccct gtatattaat tattcttggt ttttttcata tattattctc
     3901 aatccttcta gtgttaaaaa accatctaca taatctatac ttttcgtctc tgaagcaatc
     3961 agtttagcta atccacctgt agctataacc ttaacatcat cacaattcaa ttctttcttc
     4021 atcatactta ttattttgtc aactaaacca acatatccat aaattattcc agattgcatg
     4081 gctgatacag tactcttaca aatagtcata cctggcttag ctaattctac tctaggtaat
     4141 ttagacgcac tttgaaataa cgcctcacta gatattttta ttcctggtgc tattgttcca
     4201 cccaaatatt cacctttttc agagatagca caaaatgtag ttgctgttcc aaaatcaaca
     4261 agtatacttg gtgctccata cttttctatc cctgctacag cattaactat tctatctgcc
     4321 ccaacttgtt ttggattatc atattttata tttagacctg tttttatgcc tggacctact
     4381 attaatggct gttttttaca gtactttata caaaagtttt caagagaatg cataacattc
     4441 ggaactacag atgatattat aacatcatca atatcactta tattcacatt atcataatca
     4501 aataggttac ttatcaggat tccatattca tcagacgttt tttccctatc tgttttaatt
     4561 ctccagtaat taactaattt gtcaccttta tatataccta aaaccatatt agtatttcca
     4621 acatcaaata ctagaagcat atgtcattaa ccttctttct attttttgct tttcttaagt
     4681 acagtggcaa cagcagctac tactaaagcc cctactattg cttctggcac cccatttgct
     4741 gcggcaagag ccattattac ttttcctgct gaaccacttt tacccattgc atgaagatac
     4801 ttgtcagcat ataagacata tatcattcct aaaactccag ctgtatttaa cagagaacct
     4861 attgcccctg taattaaacc tgatatgtat accttatttg tagccttaat tattaactga
     4921 tatacataat aagctaatac acctatcata actcttggta atattgaaac taatggattt
     4981 ataaaaacaa aagatgttgc tgttgggttt gttatagcat ttaagagact tgatatccca
     5041 aatataaatc ctattgctgc cccaactatt ggtccttcca taatagctcc aataataact
     5101 ggtatgtgca ttatagttgc ttttgtaggt ccaactggaa taaatcccaa tggagtcata
     5161 gatagcataa tagaaatagc tgatagtact cctattatag tcatctttct tacatttact
     5221 tttcttactg atgcacttgt gttcatcata aaaaatacac ctccgttcca gctcattaag
     5281 atgccggact acttaatttt ttaatttttt tcgttttttc ttataactat gagtcaagct
     5341 accattgtag gatgcccgct ctaacaagaa taattttatc aagatgagtt gccattgtca
     5401 acaatttgac aagaaaaata tgctaatttc atcatatttc tcgttttttt actatatctt
     5461 tatatgccat tatattttct acactatccg ctttttttac tgcatttatt atactttttt
     5521 ccacaacctc tacagccaat gaacctacta atgttatatc tgcttctatt tctcctgttg
     5581 atattgtgaa tattgtatct ccatcatgag gtgtatggat aggaaaaata gacttagcat
     5641 atccatcatg tcccatttga gatatctttt tacatccagc tttggttaac ttagcatttg
     5701 ttgcaattat cccaattgta gtattatcta cactaaatcc acctttactt tcaccttgtt
     5761 tcattaattt atatgtatca attgtttctg tctttttatc atttaaagca ccagctataa
     5821 ccttaccatt ttcataaaca tctccaagag catttacagc aattaatgca gatacaatta
     5881 gaccattatc taattttata gaatagctac ctattccgcc tttcatagca tattcctgac
     5941 ctcttatctt tccaacagtg gctccacaac ctgctccata atttccttga tttaaaatat
     6001 cagtatttgc aacttcacaa gctctataac ccatctttaa atctggtcta catttaaagc
     6061 tccctactcc taaatcaaat aaaactgctc ctacaactat aggcacttta cctacaccta
     6121 catcaaagcc aattcctttt tcttctaagt atctacttac accacaagtg gattcaagac
     6181 catatgcaga acctccagcc aaaactactg catgaacttt ttgaaccata tttacagggt
     6241 ctaataaatc ggtttctcta gtacctggag cagagcccct tacatcaaca ccgcaagtag
     6301 ctccttcttc acatattact actgtgcacc cagtaagacc atttctatcc tcaacctgcc
     6361 caacctttaa gccttctata tccaaaatat tattatacat atcctttttc tcctcttata
     6421 gaaacttcac ctgaaataat ttcttttata cttccatcac ttctttgaac taataaattt
     6481 ccctcttcat ttatgtctaa acatttcact agttctctat tatctccttt taatacatat
     6541 atatttttat ctataattgc agaataatct ctacatattt ttaaggtttt ttctttggaa
     6601 ttatttacag tataatctaa atataatttt tcaaattcag ttaatacatt cctaacaata
     6661 tctactctgg ataacatata tccttcttta tacaatgatg tggctttgtc agctatttct
     6721 tgttcaaaat ccattatttt aacatttatt ccaattccaa gaacaacata atttgttctt
     6781 tcaatttcag cagataactc tgttaatata ccacatattt tttttccatt taaaataaca
     6841 tcatttggcc attttattaa tgtatttgct cctagattgt ttaaagcttt cgttacactt
     6901 gctcctgcta ttaaagttat aaatggggct ttgaatggtt ccatatctgg ttttaatata
     6961 atactcatcc agattccttc atgaggtttt gaatcccatc ttcttcccaa tcgtcctttc
     7021 cccatatctt gatgttcact taaaatcaca gtcccatcta cactatttat agctatcctt
     7081 ttagcatgtt catttgttga atctatagtg tcaagatgtt caatattttt tccaataaac
     7141 tctgtatcta atttatagta aatattctgt gggcttaata aatcagttgg attttccgct
     7201 aatcgatacc cttttttatt tacagattct atattatatc cctcttcttt taaggctttc
     7261 atatgtttcc atatagctgc acgtgacacc cctaattgtt ttgataattc ttctcctgaa
     7321 ataaattcag atttattatt taatataatc tctattattt tatctctcat atttcacctc
     7381 taatatgaca taatttcatg acttattttc ttctaataaa taattataca ttattaatat
     7441 acttttaata ctattaattt taaatttcct ttttaattat tataatggtt gttttatatt
     7501 ttatattgat gatttatata attttacatt ttatttaaat aattttaaaa taataaaaaa
     7561 actgaaagta tcaattaaat taatacatgc aaatataatt tgcttattaa tttaatatta
     7621 tactttcagt tttagtattt aatccacatc agataataat cttaaaatga ccaaggtctt
     7681 aaaactattt atctttatca gatttatctt ctaaattttt atttatatca ataacattgt
     7741 ttctttcttc ttcatctttt tctaatttta tagttaattg ttcttcaact tctttagaag
     7801 aattttcctc tgtaactgca ttttcaattt cattcagagg taactcttta ttaaatgctt
     7861 ttacaaattg ttctgcatct aaagtttcat atataagtaa agcttgtgct acatactcta
     7921 atctatccat attttcttgt aatatacttc ttgtcttatc atatgcacca tcaactatac
     7981 gctttgtttc ttggtctatc tcaaaagcaa cttcttcaga ataatttctc ttacttgaaa
     8041 aactattacc taggaatact tcatcatcac tgtcaaatga cattggacca agtttagaac
     8101 tcattccata ctttgttacc atacttcttg cagtagctgt aactctttct aagtcatttg
     8161 aagcacctgt agatacatcc ttaagtacta gctcttctgc tactctacca ccaagtaaaa
     8221 ctataatatt ttctttcatt tcattttttg tagcatagaa cttatcttca acaggaagtt
     8281 gcattgtaaa ccctccagct cttcctcttg gaactattgt aacttgatga acaggactta
     8341 cttcttcaag tacatgggca caaactgcat gccctccttc atggtatgct gtaagtcttc
     8401 tttctttctc acttattact ttcgattttt tagccacacc tgctataacc tttgttatag
     8461 cttcttctat agtttccatc ttaattttct tttctctttt tctagctgtt aatattgcag
     8521 cctcattcat taagttctct atatcagcag gagtaaatcc tggtgttctt ctagccaaga
     8581 catccatttt tacatcatca cttaatggtt tatttcttga gtgaacttta aatatagcct
     8641 ctctaccttt tacatctggt gtaccaacaa caacttgtct gtcaaatctt cctggtctaa
     8701 gtaaagctgg gtcaagtata tctggtctat ttgtagctgc catgattatt ataccttgat
     8761 ttaccccaaa tccatccatt tcaactagaa gttgattaag agtttgctct ctttcatcat
     8821 gacctccacc aagacctgca cctctttttc taccaactgc atcaatttca tctatgaata
     8881 tgatagctgg agcacttttc ttagcctgtt caaataaatc tcttactctt gaagcaccaa
     8941 ccccaacaaa catctcaacg aaatcagaac cacttatact gaaaaaggga actcctgctt
     9001 ctcctgcaac tgctcttgat agatatgttt taccagttcc aggaggtcct accataagca
     9061 ttccttttgg tattcttgca cccaattcaa tatatttctt aggattcttt aagaaatcta
     9121 ctacctcctg caaatcttct ttttcctcat ctagtccagc tacatcttta aatgtaactc
     9181 tagttttttc atcatcttta tgaaccttag cttttgattt gccaaaactc ataacctttc
     9241 cgcctccacc ttgagactga ttcataaaca cgaaccaaat aatcaccatg aagaatatta
     9301 acagtaatgt aggcaacatt tcgacaaacc aaggtgtaga tggcttagct tcaccaccaa
     9361 aagttagttt cccagcctta gcttggtcta acacctcatc tgcaagttta tttcccatca
     9421 cttctgttgg aacatatgac ttaaactttg tatttgtatc ttttatagta ccttctacag
     9481 aagtttgatt tacaaagtat aatcttgata tattctcatc tgttaattct ctatatactt
     9541 cagagaattt taaatctttt attttttctg taggcttacc tgagaattga actataccta
     9601 ctataattat aaaaacaagt agataaaaac ctgccccttt tagcaactta ttcaatatag
     9661 aagccctcct ttcatacatt gctttgccct ataatttgtt aaaattaatt tttaatactt
     9721 cttttgtgct ttcatcaatt ttataatttt cactgatttt ataatctcca acacatatta
     9781 ttccttcacc atctgtgatt ataggaattt tacatctttc ttctcttggg atttttaaat
     9841 ctatgaataa atctttcact tttttacttc ccatagcaag ctttatctta tcaccttgcc
     9901 ttctgcttct tattactata ccccctttta ccttattaaa atcaaaccct ttagatgaat
     9961 tgtctaattt catactctta tacctatcta tgctcattac ttgggtctca ataatttgtt
    10021 ttaattcttt tattttaata aacccattac taggtacatt gtaataaaat tcaatttcct
    10081 cattaacaat ttcctcattc gttaatatta tactgtcttt ttttctataa acaaatatat
    10141 ttcttggaag agttaacatt ttatttactt ttgaattatc ttctaaagac attatatctt
    10201 ctatatgtct ttggtcaaca aaattagtat ctcctagtat atgttttatg gaatttctaa
    10261 gaactctaac tttgatagca tcatgtaagc aaacaaaatc gtctaaattt atctctacaa
    10321 agcctttttc ttttatattt gaaacttctc taaatttagc ttctgcctct ttctcaatat
    10381 aatcgttatc actttttaaa ctattgctca tcctcactat agattctatt acatttgaat
    10441 taaaattatc cttcatatat ggtaaaaggt ctaaccttat cttatttcta gtgtatatat
    10501 tttctaaatt tgttttatct atcctcggat ttaaattata agcttcacaa tactcctcta
    10561 tctcatttct ttccacgtct aatatgggtc taattatgca attatctcta atataatcaa
    10621 ttccctttaa gccttttaaa cctgttcctc tcatgatacg catcataacc gtttcggctt
    10681 ggtcattgag attatgacct attgctattt tattggcttt aatcttatcc ttaatttcat
    10741 aaaacatttc atatcttagc ttccttgctc cttcttctaa tgataatccc tcattttcac
    10801 aatattttgg tacattaata gactttacaa agaatataat tcccatatcc tcacaaagtt
    10861 tagatacata taatgcatct ttttgagctt ctatccctct tatttgatgg tttaaatgtg
    10921 ctgcatatat ttctatatta aaatcttttt ttaatctatt tagtacatgc aataaacaaa
    10981 ctgaatcagg tcctccagaa agacctaaaa ctattttatc gcctttttgt attaaattat
    11041 gtttatttat agtacttagt accttatcaa atatcatatt tatccctctt acacttagtt
    11101 ttattcactt ttaagtatac tttctataaa aaaacgctaa acccttgtat caattttaag
    11161 aaattaaagt ttaatataaa tataataata ccaaataaat taaataaaag gtagtttttt
    11221 cactaccttt ataaaatttc tggaaaatag ccatagttat tatttagtac ctatgtatat
    11281 atctatttta ttcctaccta aaaataaatc ttgtaccttt atattatagt ctattttcaa
    11341 ttttatgtgt tccccttctt gtatatttat atctaattct cttgtatcaa tatcaattaa
    11401 taaagtacct tgtggggtca catactttgt agtactactt tctccacatt taaacagcat
    11461 tgttgagtta atagcaccaa actttttgat actaacttga tttttaagta tctttatagt
    11521 attagttatt tctatatctt cttctttttc cttgtaaata acatatattc catcattttt
    11581 ataaaaaatt ttaccaaagg cagtcatctc tatggtgtcc atatttcctt tttcatcata
    11641 ttgtctagta tttatactta tttttacact caacgatttt tcctccatag attcttcata
    11701 taaactagta tttttgtatt tctacttttt gaatcttatc aatttttttc tttaagaact
    11761 ctcttgctat atctgaaaat ttttcaggta tatctgatac ataatattga taagttccat
    11821 gaatttctgt attgtttata atattttgca cctctaaaat cttttttaaa tcctttgcag
    11881 tctctttagc tggattaaca agttttatat gctctccaac ttcttcacct attgttctct
    11941 ttaaaatagg ataatgagta catcctaaca ctaaagaatc tatatttttt tctttcaatt
    12001 cttgtaaata tatctttgct gtcagtttag ccacttctgt atttgcccat ccttcttcaa
    12061 caataggcac aaataaagga catgctttat taacaatttc tatactctca tctattttag
    12121 atatttccaa gttgtatgct tttgaactta tagttccttc agttcctatt attcctacaa
    12181 ttttgttttt tgtagaactt acagctgttc tagctcctgc ttctataact ccaattatcg
    12241 gtatatcata tttttcttga gcttctttta agcttcttgc agtagcagtg ttacatgcta
    12301 taactatagc ttttacacct tttgttttta aaaagtttat agcttgaaaa gtatatttaa
    12361 ttatagtttc tttggatctt gaaccatatg gtattctggc agtatctcca aagtatatta
    12421 tatcctcatt tggtaatatc ttcattatct cttttagaac tgttaatcca cctaatcccg
    12481 aatcaaaaac tcctattggt ttattgttca tctttataca acacctactt tacatttttg
    12541 tgtttaacaa caacttattt atcgctaaaa tttatattta tattcataat taatatatta
    12601 ttacctaaat gattattata gtttatttta cacaaaaaat aaaggagcta tcttaaatta
    12661 gaaaataatt tctacaaaaa gacaactcct ttcactactt aaaaatttaa atttattttg
    12721 caaacacatg atttcctatt ctcatataag gattcaatct atttatccat ttgcaagtgg
    12781 ctatttctgg attccaaaaa tatactgctt tattagttgg gtcagttcca taaagagctt
    12841 cctgagctgc tttacgtgct gagtctgttg gtgccatctt tattgaacca tcaagcacaa
    12901 ctgagaaagc atttttttga tatatgactt cttctattgt gtctggaaat ctagggtcca
    12961 atactctatt tattactaca gctgctacag caacctgtcc ctcatagctt tctcctctag
    13021 cttctcctgc aaccaactta gataataaca tcaagtcatt atcagataaa tttattactt
    13081 ctttctttgc tatatttttt tcttgtttgt ttactttctt aatattttct gttggttcat
    13141 atgcaaatac ctctttaata ggcataaata taaaagtcaa agctaatagt gtagccatca
    13201 gtttactcca cctgtccatg attaaaacca ctccttacat tcttattttt aaaatttttt
    13261 ctctaaatcc ttgactactt caagtacttt aaacttaatt tttactctac ttgttttttt
    13321 tggtgtatct tgttttatta acttatattc tttatcagtt aaaacttcct tcaacttatc
    13381 atctgtagat ttatctatca ctccattaga ttcatcaaca aaacatagtg gagggaacat
    13441 aacacaccac cagttttttc cttcaccttt cccaataata atctttaatg ctttatattc
    13501 accagctgga agaactatat tagaatattg tttagtaggg aaattgctat attgtatacc
    13561 tacctttaca ctgtaattat atccattttt aagaataata tttttactta tttcttccag
    13621 actactatat tcctttttta taatagcttc actttctttt atactttttg aattttgaag
    13681 ctttggctgt aaatatttta ttacttcatc tctaactttt agtttaagtt cttggtcttc
    13741 atctgtattg ctgtttgcta taacatgaaa tcttattaat ttatctttat aatcttttga
    13801 tatattgtct acttttttta cctcaccatt tattactatt gtcattattg atatgactga
    13861 tataagactt aatattaata gtcccaatct aatcttaatt tttctcattg aaaattcccc
    13921 ctcaagataa atttatatca tcaattatgt ccaattaaat ttaatttatt cataatattt
    13981 tttaatacta ataaaaaaag ctatcttaaa atgattacaa tcattttaaa atagcttttt
    14041 aaaccttata ttttataagt ctttactaat catagcctta tctatcataa actgctctgc
    14101 tttttctata tgctctgtag catacttctt ggatagctca ctatcacctt taattatagc
    14161 atcaagtaaa tatttatgct cttcaacaat attatgtgat gtatcataag cagacatata
    14221 ggtaactcta aatctatata cttgttccca caatgagttt attaattgga ttaatttttt
    14281 attattagtt gctttaaata tacattcatg aaattctaca tcaagtttta ataacgcatc
    14341 tacatcggat tccaaagtgc tttttttaaa ttcttctgat atatctttaa gctttttaat
    14401 atcttcatca ctaattcttt cagcggcaag atatgctgct aagccttcta ggcttgctct
    14461 tacttctaat acatccataa tatcctttaa tgacatattt gccacatacg caccttttct
    14521 aggcaacata acgactaaac cttctaattc aagctttctt attgcctctc tcactggagt
    14581 cctacttact cctaattgtt ctgctagttg cacttccatt agcctttgac caggctttaa
    14641 ttttccttct aagattgctt ctcttaaatt ctcaaagact acatctctta atggcttgta
    14701 attatccaag ttcagtttag ttaaattctc cacaaatttc aacccctttt tgactgctat
    14761 taacaacata cacctgttta tattttttta ataattcttt ttttccaatt agagcatctt
    14821 ctttattttt aaatagtcca aaaactgtag gaccacttcc actcatcata gaacctaaag
    14881 cattattttt catcattact tgttttatat cacttatttc tttgtgttta cctatagtaa
    14941 cattttcaag aatatttacc atgctttctg atacagcttt tatatcttca gattttaaac
    15001 actctatcaa atatttatta tttggtcttt ttttaatatt attcaaatct aatccttgat
    15061 aaacttcttt agtagaaacg aataagtctg gtttgcatat caatatattt gtatcacatg
    15121 gtaaaccttt gatatttgtt agcttttctc caataccttg agctaaggca ggtcttcctg
    15181 atatacaaaa aggaacatct gcgcccaaat taagtcctat ttcttttaat tcatcttcag
    15241 ataatctaag ttcccatagg tgatttaaac ctactaatac tgcggctgca ttagaacttc
    15301 ctccagccat ccctgctgct acaggaatat ttttttctat gaatatttct acaccttttt
    15361 ttatataaaa tttattttta agtattttgg cagctttata aacaatatta tcttcatcta
    15421 aaggaatatc taaactagtg ctttttacct ttatttcatc ttcgtctaat tcttttatct
    15481 ttactatatc gtataaatct atcgtttgca ttatcatttc aacaaaatga taaccgtctt
    15541 gcctttttcc caagacatca atggataaat ttatttttgc tctactcttt agtcttataa
    15601 aatccattct atcctccttg tttaaagaat aatgcatcac taacaataat attatactac
    15661 aaaaaataaa ataatagggt attataatac cctattatac ttaattactt taaatttttt
    15721 aatattaatc tactaatacg actttttttt ctaaaataag acacttccca ggcttaattg
    15781 gttcatcaag ttttatatca ttaagttctg caatttcatt ttctgttgta ttgtattttt
    15841 ttgctatatt ccagaaagta tctccttctt tgcatatata tacgattatg ctaggagctt
    15901 tagataaatc atatacacct tggtcttctc ccttgataat aaaattttct gctttcttat
    15961 ctaatgcttc agtaaatctc ttaattttga taatcaagtc tatctggtcc ctattcaaat
    16021 caacttcgac tttatcaata catgctgtat taaacacaga tgctgtatca gttagattat
    16081 ccatttctat atcatgttca aatggaattt cctcactaat tttataaacc aattttaaac
    16141 cttcaactgg gacaaataaa atttcaactt ttatgattcc ttgtataatg cttttatttc
    16201 cttcaatata actattttct atagacatgg ttggacaaac gcttacaata tcttttattt
    16261 gtatatcatc attatcattt cttatgcctt ctctaaccat aaatgtttct tcactacgtc
    16321 ttaaagtctt atttaattga ataggtttgt ggtcaaattt tattatcttt tgaggcgaat
    16381 atgcatcttg taatacttct cttgtaactt catctgtaac ttttacctta caacaagcca
    16441 tacaatctat ttctaaaaga cctgtgttgc tttcactatt ttgcttgaaa atatgattaa
    16501 aatctgacat agacaacaat acttcttcag tcataccatc actaactcca gggacttcta
    16561 caaattgagt aaactcaata cctactctat ccaactctac aagttcaccc tcatatgtac
    16621 aagctaacgg atttatttct aatactccac caataataac tttattgtca gtcactctac
    16681 tttcttttac tttaacacat ggatttaaac ttattataga ttgaatttcc tctgtgttta
    16741 ttgttatagt atctcttata gaactttctg ctttttctat tccaactata tcttgaaaac
    16801 aaatttcctt tctgtgcttt tgtatgcatt ccacttgcgc cacatctttt acaatgtcta
    16861 acctttgctt ttcaaacaaa cttcccctta tattcataag agctcctact ttaatctttc
    16921 tctcattcat tatagtacaa tccatatgct ctacttctga aaataacatg tattccatat
    16981 cttgaataac attgtctttt tctattactt cgtttatatc tacttttccg tctacattag
    17041 aaatagtatt tttatcatct gcaatataga ttacattata attaaaacta cctctgcaaa
    17101 gtatcttccc atctgccatt tcaatttttt taagtgatat gtatccttct gtttttacaa
    17161 tttcatatac atctaatttt ttgtctggca caactgcctc cgcttcaatg aatgtttgaa
    17221 attttccaaa gtctattcta ttgtcaactt taattacatc tttaattaat tccatagtct
    17281 acctccttaa gtattataaa aatatcacac tatatttata tttaaggagc aaaaaaaaaa
    17341 ttacacctat ttttaaatag gtataatttt aacttatttg taatttatct tgatctctaa
    17401 aaacttgcaa ctttacatta gatgttaata aatctgagta actataagat actctaggat
    17461 atccattact ttcatcatct aactttataa caaacacgct tggataaact ttttctagta
    17521 taccctcttt tgtaataatc tgctttcttc ctttattagc tttcaacaat attttctttc
    17581 ctatatgtct ctctaagctt actcttatct tatctagagt ttgaacagta gccacaatat
    17641 caccttcttt aacgtttata tgtttacata atatcacata taaacatttt tgtcaaatgt
    17701 ttaaactaat tattttatat attttttgca aaaatgtcaa tactattttt gaagatatac
    17761 agtataatta tgttaatttt tgctaatgta atattgtttt tggcattgcc catctaaatt
    17821 ttcctcttgt ttcagaacca ccaattccct taacacctgt aatagtctgc tctataacct
    17881 catcaatagg aactactaca tcaattcttg aacaagcaat tttctccact ataaaaacag
    17941 ggtctaatgc atgtatcatt attcttccag gcgaacttgc atagtttgct cctgcactta
    18001 ttattttttc ataatttgat tggcatgctc ctgcgaatat gacaagatta tccaaatttg
    18061 gttgccattt acgtgcttct tttactgttt taacaaaatt tgaagagttt ctatagttac
    18121 tcatatcttc tatatctcct ctttttattg tcattgcatc atgacctgtt attactagta
    18181 tatccggatt atatttttct agtagtgctc ttacttcttt atactgattt tgctctgaaa
    18241 cagctacacc tactgcaggt attccaagtt gagcatatac atccaagcaa atttttaaat
    18301 attctttatc tccatctatc tgtagtactt ttccaggcat tccatatgtg ttaggattta
    18361 attgaagttt tggaactgct ctagtcattc ttttttgtct ttctttagct tttcttactg
    18421 acttatataa taaattttct acatttttat ctattaatat atcttttata tcaggtgctt
    18481 ttactaattc taggtcatca atataagcat ctgctattac tctaaatgca attcccttta
    18541 gtatagctat tttctcatta ttttcatcta caccaaaaga gactatttta aatactatat
    18601 ctttgttatg tgactttcta gctacaatgt ctcctacctt catagttaaa cctccaataa
    18661 atttttatct tagtttatac tatgttcgat ataaaacttt gtttcctaat gtcaaaaaaa
    18721 catttcttat aatacttctt ttatcactct taaagcattt ttatagtata tcttttctat
    18781 atcatcttca ctaaaccctt ctttttttag aggttcatac agtttaccca tctgagatat
    18841 atcttcaatc tcaacttttg aatctattcc atcaaaatct gaccctagag atacaacatc
    18901 tattcctcca acatttacaa tatgttttat gtgtctaacc atatcttcaa gtttactttc
    18961 acttttatca cttaaaaata agtggaagaa gtttatacct gtaactccac ctttatttgc
    19021 taatacttta atcatatcat cagttaaatt tctagaatga ttcatcattg ctcttgaatt
    19081 agaatgtgta gcaattattg gtttagaaga aatctttgca atttcataaa atccaccatc
    19141 tgaaatatga gaaacatcaa ccaacattcc caattcattc atcttatgta ccacttctct
    19201 tccaaaatca gtaagccctt tttctctata ttctacttta ttatgaggaa agctcaattc
    19261 attcacatga ttccaactta ttgtcatcat tctaacccct aagtcgtaaa atttctttaa
    19321 attttctaat ttaccttcaa gtactgcacc ttcctcaata gataaaagag ctgtaagttt
    19381 accttctgat tggtttttca taatttcttc atagttagta gctaaagcta tttcatcact
    19441 attttttttc atttcctcat gaaatttatt tgccatactc atgcaataat caaaaggatg
    19501 ttttacttct tcagtatcaa caaaaagagc aaatgtttga gctaatgaat cccccttttt
    19561 caatctgtct atatcaacag aatatttatt agacttaagt tcacttgttt ctacattttc
    19621 cattaatttt gctatagtat cacaatgtaa atcaagaaat ttcatattta taccccctgt
    19681 atattttata tttatatcta aaaatagaaa tagttgtcct tatagacaac tattgacaac
    19741 tattttttaa tattcttttt aatattactt aatcttattc ttcttttaag ttaggtatta
    19801 cttttttaac ttcttcaatt tgatgccatg ttttatctat attattttca ctaatatatt
    19861 tttttaaatc agttaaagat gtaaaatctt taactgataa attgtcatca tcatctgcaa
    19921 atcttaaaat aaacatgaga ctcccttact ttccacaaca tttcttatat ttttttccgc
    19981 ttccacatgg gcatgaatca tttcttccta tttttgcttc tttaactatt gttttagact
    20041 tcttataagc ctttattatt tcttttcttt ggtctgctgg tagtatatct tcccaacctt
    20101 gtaaattata tagccaatga gcctcaacag ttaccatatt gttatataat ttttcccaat
    20161 ctatttttat agaaacttct ttatcagctt ctacttcttc taaaactata tcttctttta
    20221 agctttcact tattccatct atgaatccca tgaaaaattc attagtagtt ccaaattttt
    20281 cagccaattc acttacttta ccttcaacaa catccatttt attatttaat atttcattgt
    20341 atattccagc ttcaactttc aaatattctt cccagaattt tacttctgct tcttgacttt
    20401 catgattatc acttaaattt ctccattcag tatataaact catacttttt cctcctaagt
    20461 atacctatat ttttatagtt tttatagtat aaaatctttt agttagattg gaagtttctt
    20521 ctttttgatt ataccatatt ctatttaaag ttaactctta tattatatca taattaaaca
    20581 attcttttaa tacttttata gcatactctt ggtttataaa ataagggctt gtcgcaattg
    20641 ttattacttt ggctttttta attaagtttt ttatcttgta aaatttgagt tcaaatggta
    20701 tatagtccat atcacttgaa aatatatcca aatctatatc aagaacaaac tctgattcta
    20761 cttctaaatc aaatccatat agactatcta ttattattaa ttctgaaaat atgttatatt
    20821 ttaaagcagg ttttataaaa cttcccacat ttaaaacttc atttgtatat ctaaatacat
    20881 cttttagatt atttacatct acatcatagt tctcaggttc tctagtatcc ttatgttggt
    20941 ctacatgcac taacttgcat ccttttgtaa actcaccctt taacaaagat tttgcccaaa
    21001 aataaaatgc atggttatga ttgtcaaaca catatatctt tttatttccc aggacatatt
    21061 cgaccatatt ctccaatcct tttgctttta tttccttatt ttcatctact tcattaaata
    21121 ctacctcatt gcctaacctt acatcattta atgtaccatt tattagtttt ggaacgtata
    21181 tgctcttatt ttctctttta tcatatgaaa atacattatt tcctactggt ttttctatat
    21241 aaaatccact atattcataa ttttccataa aactttattt cctccattgt tatataaata
    21301 tataagttat aattttaaaa attaaaatgc acttattgta aatcatatca tctattatag
    21361 aaaacatctt atataactaa atataatatc ttctctcaat atgtattata caataagtgc
    21421 aaaatatatt tatataaaat atactacatt cctataacaa aaccatcagc ttcaattgga
    21481 aggtaactaa ctcttctatt caactccacc tttccaaaaa atactaccca atatggtcta
    21541 aaaatacttt caattttaac tatttcaatc tctgggattc ctcccataaa cctatgagtt
    21601 aatctcatag ccattttatt tgcctttgct tttactcttc gttcgtcctt atcactatac
    21661 tgcacaatat tacaatccac attttttaca acttcatatg taggaaaatc ttgtactata
    21721 ctaccagaac ctgtagaacc attcactaaa atttttaatt catttatatc attagaatat
    21781 ctcctattct tgaaaatgga tttcgttttg tgaattttaa gtgtgataat tttaaactct
    21841 atataatgaa gtctaacttc atgagcatat ttgttcttta atattagctt actaaataaa
    21901 gaattttttc cacttttagc tatctctata gcttcttctt ttgtaattct tataggtaac
    21961 gctcttatat ccataaaatc attctctttc ttattttttt cttgtcattt ttaaaactct
    22021 atatatataa tcaaaaaata ttacaattac aactgccata actccatatg gaattatttt
    22081 tccaactata atatcatttc tagtcaatat accataaaat ataaatcctg ttattaaaaa
    22141 gtacaataat actagaaaac cgtctattcc aagccatttt atttctaaat ctttttttac
    22201 cttagacact aatttagaca tagcagtttc tccttttata gattattttg tgtatttaaa
    22261 ttttcaccga ttctattacc aatcatccat gcaataaatg aaaaaggtat agctatcaca
    22321 agaggctcta actcaaagct ctgaactgga aatattttaa aataaccaaa agtcactcca
    22381 ccaacaatca ttcctaaaat accacccata gatgttcttc ttccatttcc aagaagccca
    22441 cctactatag gtacaaatgc cgaacccatc caaatacttc ctacaaatat acatgcatca
    22501 tatacatttt caaatctaaa tgctacgcta agccccataa ctgctgctaa acatacacct
    22561 attctagtaa actttactaa ttgtttctga gataactctt tttttgtaat tcttccatat
    22621 atatcatttg ctaatgtagc cccagctgct agataatagc tatccaatgt tgatattata
    22681 gaacctaaaa ttcctattat aaatattact cttattcctt gtggtaatgt atctaaaact
    22741 aaagttatat atccagcagc tggagccatt tctggataag tagctcttac tataagtcct
    22801 gtcatagtta acaccatgtc aaaacatatc catagtgaaa aacaggttaa taaggctctt
    22861 cttccaacct taggagaatc tgctgctgaa aatctttgat aaaaagttgg gtctgaataa
    22921 gctccaaaag aatatacaat taacatcaat gctttcatag ctgacatacc ttttgtaggg
    22981 tgcataagct gtggtgcatc tttgagtgct tctgtaagac cttgaaaccc tcctatttgt
    23041 tcaaattgac ctggcataac catagttaaa ccaaatacca tacaaaaaaa caataccata
    23101 tctgtaatgg caactcccat aagcccacca agtactgtaa gtacaacgac tactcctacc
    23161 attattaatc ctattaattc tttatctatt ttccatgcta cgttacctat agttcccata
    23221 gcagttattt ctccaagttg tgcacaatat ataaacatca aaattgcccc aattatagca
    23281 acatgcttgc cataaaaact ttccagtaaa tcaggaactg ttatattggt tcttatatga
    23341 atccttggac caacccacaa tgctaaaggc attctcccaa tatgtgcagc tattgaccaa
    23401 actgcccatg cagatattcc atatatagcc gcatactcta cactacctac tgtaccaact
    23461 cctccatacc atgatgcaac caaagttcct actattaagg accatggtaa acttcgattt
    23521 cctaggtaat aactttccat atcttttaca tttctagaaa aataataacc tattcctaat
    23581 aatataaatg caaatataac tataatccca ttttcccaaa atgttaacat atctaatctc
    23641 cacattctta tattttaatt tttaacttta atatctaaat atgaacaact ctacccattt
    23701 ccataaaaat aggtagagtt atataataat tataagtatt taagtaatct tgttattaag
    23761 caattttatt gtttaaacct ttattttctc ttttatttat tttatttaaa gcataagtag
    23821 caaatatccc tataactgca catactacag ataaaataaa tatatatgta tatcctgttt
    23881 gtccatattt atctaaccaa ttacctgcaa tagtgtaata aaacgcatct ggagaaaatc
    23941 ctataaatga agcaaatcca actactgctc ctgtagtttc taaagatata ttagactctg
    24001 aaacagatgc aaagtatata cctctaaatc caaataaaat tacacttagt attatcatgt
    24061 ttattacagc tatccatata aatcctgtac tcttaggaat aaccaagtaa gcagctgtac
    24121 ttactgtcat taatataaat cctacaaaca ttactcttat agatgaacca actttatctg
    24181 ttataacacc agcaactgga gatgctccca tttttataac ataagttctt attattgata
    24241 aagcagaaac tagagtcatt ggcattacat aaacttctga taagtatgga cttaaataag
    24301 ttaaacttga gaatactaaa taagttgaaa atattataag accaattaac caagcctttg
    24361 gtattgtaac tacttttaac aatgacttaa tacttaatcc ttcatctgat gctccactat
    24421 cttttttctc ttccactaag aaaaatagaa gtataccaca tattatagat gctgcagaat
    24481 ataaccatac tacatatttg aatcctactg ttatttcagc aaatttacca aagaaataaa
    24541 gacctataaa agaaattaat gtacctgata cacctgataa cccttcataa aaaccaaata
    24601 ttcttccttg ctctgactca cttccttgca ttctaacaac cttaacagag gctgagaaga
    24661 aggttaatat tgtcgtaaat ccccataata caaatattaa aagtatcata ctatatgatg
    24721 ggaatgtaga gaaataaaat ccaagtatcc ctgaagcaat taaagaaaaa gttattaatt
    24781 ttctaactga gaatctatct gcaaaccatc ctcctataaa ataagatacc attcctacta
    24841 atccatataa actcaataag ttccctattt gtgtatgact taatgctaaa gcttgttgca
    24901 ttgggtcata aaatgatgat ttcatatatg gtaaactata catagctgtt gttccaaatg
    24961 ccaatatgaa tattatcaaa aatcttttaa cattattttt gctttccatt gattctctct
    25021 ccttaaaatt ttattgttta taatctcatt catataattt tattttaatt tttctattgc
    25081 ttgtttaaaa tcatttatta tatcatttga agattctaat cctacagcta ttcttattag
    25141 attttcccca ttcatttgaa ctaatgtatg ctcttcccct aagcttgttg ctattgttgc
    25201 aagctctaaa gagttcatta atcttctact agcttggtct cttgtcaatc cactgatacc
    25261 atccttaagt ttaaatgaaa ctacgcctcc acctaaacca ttcatttgag ttttacaaag
    25321 ctcatattga ggatgtgatt ttaatgctgg atactttacc aattccacat tctcttcttc
    25381 ctctaaaaac tctgctactg ctaatccatt ttcacaatgc tttttcatcc tcatatctaa
    25441 cgttttcata ccccttaaaa tcatccatgc actcattggt ggtaaagatg ctcctgtaaa
    25501 acaacataaa cttggccatc taactaaatc tattaattct tttgaacctg ctactgctcc
    25561 ccctaaagta tctccatgtc catttataaa cttagtaaga ctatgtatta ctaaatctgc
    25621 acctaaatct attggtcttt gtacaattgg tgtcccaaaa gtactatcaa ctatagctaa
    25681 gcttttattt tcatgagcaa tttctgctat tgtttttata tctactaagt ctaatgatgg
    25741 atttaaagga ctttctatat aaactatttt agtatttggt ctcattgctt cttttacatt
    25801 ttgtggattt actgcatcta caaatgtaac ttcaactcca aatttagata acaactcaga
    25861 catgaataat ttagtgtgtg aaaatattcc atctgaacta actatatggt caccactttt
    25921 taccaatgct aatatagtag atgttattgc ccccatgcct gatgtactag atatggcact
    25981 ttctgcattt tcaagcatag ccaacttagc ttctaactct gtaagagtag gattacactc
    26041 tcttgtatac acatatcccc atgtcataca caactcttca aaatgctcta ctgtctttgc
    26101 agcaaatgtt gctgtttgac atattggtgt agccaatgca cctgttgttg ggtctgcact
    26161 atgtccccaa tgtattattt ttgtctctaa atcttgatta atattgttac tcattttgat
    26221 ttcctcccat tttgacttat ttatacaacg ttttccctgc caaatttcat caatttagct
    26281 tagtcttaat acattttttc aagtatactt ttttatttgt tataatttct aaaaatatga
    26341 cacttatttt gtttttttac agttctaatt ataaactcta tagtaactat agagtcaata
    26401 tgtttttgat atttttttta caatgtttaa aatagtcaat acaaaaatag gtatatctta
    26461 gaataactaa agtcatccta agatatacct atttttatat cacaatataa ataattacat
    26521 ataagcatta gtttttttat cataaataga tttttcaaga tttatcattt tttcataaat
    26581 atattatagt taaatatttt aatattacct aacatctaca ataaaatata ctcttaaaat
    26641 aaaattatat aattaaaaat actctataaa agctaaaaag tttttctatt cgctacatct
    26701 aaaaataatt agatagaggt ataaatgtat ttagtttatt tatacctcta gtcttttata
    26761 aattatatct ctactaaatt gattttttag cacgaataag tgtgctcttg gagataccag
    26821 tcatcttcac aacctctcta tatggcttag aattaataac cccaatgcat attgtatctg
    26881 ttgattgctg tatttctttg gcctaccatc tttaaagtcc tttttctttt tagcaaattc
    26941 ttttcctaat tgagtacgtt ctattatcat atttctctca agttctgcaa ctgcaagtaa
    27001 tgtagtcaaa aagaatttac ccattgaagt attttctaaa aggcctatat ttaaaatatg
    27061 aacacttact tctttagcaa ataaaccttc tattagttgt attccttctg atgtacttct
    27121 agctagtcta tccagcttag ttgcaacaag taagtctccc ttttttagag atgatataat
    27181 tttttcaaat ttaggcctgt ttgtagtagt gcctgtataa gtttccttta ttattttagc
    27241 atcattatat ttattcaaaa tttcttgctg ttgctgatac aaactgttgt tgtctgtttg
    27301 attttttgta cttacacggc aatatccata tataataatc atcacttcct aacataaaga
    27361 ttttgtacag aagttaccca gaagcttgtt tttacttatc tttatccatt ttactaaaac
    27421 gatttttggg tgtcaatact gttaactttt gacaccataa taattccttt ataatttgtt
    27481 tgactatgtc aaaaattacc aatataatga aattaatgag tttatacaaa ttggaggaaa
    27541 taatatgaat agtctgttaa aagaagcaat agatgaatta aaaaacatcc attgcgggga
    27601 agttttttta ttaaaagaat tgttcaaagg ctatgaatgg aacaggttgg agatgaatat
    27661 cagattgaaa ttaggaaaac tttttttgta tgaagtggta actaatccca atttaaatgt
    27721 agaggtcatc aataaaaatt ctgcttatca gcaaatgtat aaaaaaaaat agtgacttaa
    27781 atgtatataa tagtataatc ttcttattga ttcaaaagtt aaaactttta atacaaaaca
    27841 atcattctat tttaacattt atcaatatgt ctaaatttat ataattaaca catacgaata
    27901 gtattgttta aatcacatta tttaagatag ataaatctta accctactcc agcataaata
    27961 ctaaaatagg gcttagaatt atctatattt ttatcccata aaatgcttag ctcttcctct
    28021 tgattgaaca tatatatctg gggaaataca atagaagcgt aaatttataa aatttccaaa
    28081 gtcagaaaac ttcagttcaa acttaggtat accaaaactt tcaggtgcta tttcgtcaac
    28141 gccaaaatag atgataattc cattatctgt aagataaaat gcttggtctt caggtataac
    28201 taactcaaca ttagaataat acatttctct attttcattt atttgagatt taatgtaatc
    28261 agtaattata ttaatataat caactccatc tctaaaaatg tcattaagta aaagttcttt
    28321 tccagttgtc aaatctatat tgtaattatt caatgtattg tatttaggcc catagttatt
    28381 agcaaacccc ataaggttta atatcatact cagtacataa tttttattaa aagtaactgc
    28441 gtaactggta gatacccaat agctttgttt tggaagtgaa ttttgagaag ctgcgttatt
    28501 atattctcgt tcttcttcct gtaagccatt tttaaaatta tttacagtca ttcttacagc
    28561 attgtttatg ttatttaaaa taactgggtt tacatacgtg gattgatttc taatattgta
    28621 tataacagga tactttacat catatgaaaa atacttactt ctttcaaaat cttcattaaa
    28681 ttgtacatat aatatattat atgtacaggt atttgtagat tgataatttt ccattaaaat
    28741 cctccccctt ttataaaaaa atcagataca atataatatg cttaaaacag taataatgtt
    28801 aatggtaaat gtaaagaata gaaagtatct aaaacagcaa aaaatgacta attttgtggt
    28861 ataatacata ggattgagag ttattttata ggaggaaaaa tatgttatta ttagcagata
    28921 aatggaaaga ttatgaactt atagatatgg gaaatggaga aaaattagaa cgttggggaa
    28981 gttatgtact tagaagacca gacccacagg ttgtatggcc aatggaatct gaatgggctt
    29041 tatggaaaaa ccctcatgga cattatcaca gaagcaataa aggtggaggt caatgggaac
    29101 acaaaaaaag atatccagaa caatggacta taaattataa aaacttaaag tttcacatta
    29161 aaccaactgg ctttaaacat actggattat tcccagagca agcagctaac tgggattgga
    29221 tgatagagaa aataaagaaa gctaacagac ctataaaagt gttgaatctt tttgcatata
    29281 caggtggagc tactgtagca tgtgcatctg ctggtgcaga agtatgtcat gttgatgctg
    29341 caaaaggtat ggttaattgg gcaaaagaaa atatagaatt atcaggtctt aaaaatcaaa
    29401 cagtaagatt tatagtggat gatgttgtaa agtttgttga aagagaaata agaagaggta
    29461 aaaaatatga tgcaataata atggaccctc cttcttatgg aagaggtcct aaaggagaag
    29521 tatggcaaat agaagaaaag ttatacagtt ttgtagattt atgtatggga gttttatcag
    29581 ataacccttt atttttctta attaattctt atacaacagg attttctcca atagttcttg
    29641 aaaatgtatt gtctacaaca ataggtaaaa agacaaatac aggagatata tacggtgggg
    29701 aattaggaat accagcttcc agagatggta agatacttcc ttgtggtata tttggaagat
    29761 gggagaaaaa ataatgataa aagtcatata tgaagataac catttattag ttgtagaaaa
    29821 accagttaac atattgtctc aaggagataa tactaatgat aaagatatgg taaatctttt
    29881 aaaagactat attaaaaaaa agtataacaa acctggaaat gtatatattg gtttaataca
    29941 tagattggat agaccagtag gtggagttat ggtgtttgca aaaacatcaa aagcagcatc
    30001 tagattgtct gagcaggtaa gaagtaagac tttcaaaaaa acttatctag ctgttgttca
    30061 tggcaagata aaatctaact cagatatact aaaagatttt ttatataaaa ataaaaaaac
    30121 taatatggta actgtagtga aaaaaagcca taaagatgcc aaagaagctg aacttaacta
    30181 taatgtatta gattttaaag aaaatctaag tttagttcaa gttaatttaa agactggtcg
    30241 ttctcatcaa ataagagttc aatttgcaag cagaaaacat ccattatacg gagaccaaag
    30301 atatggcaaa gaaataaata agattggaca acaaatatct ctttggtcca ataagataga
    30361 aatttgccat cctactacaa aagaaaaaat ggaatttaca tgtcatccac ctgacaaata
    30421 tccatggaat atattttaaa tctcaaatga ggtgattata tgagtaaaaa attttcaata
    30481 ggagaaatgt ctaaacttca taaaataagc atacagacac taaggtacta tgaccaaata
    30541 gatttattta aacctgttca tgttgaccaa gaaagcaatt acagatatta ctcaattgac
    30601 caattttcac aattagatat tataaaatat ttaaaatatt taggtatgcc tttaaaagaa
    30661 attaagtcaa agcttgatga aaataatgaa gaaattctaa aattactaac aaataaaatt
    30721 aatatagtgg atgaaaaaat taaagaatta gagcttataa agaaggtact aagcacaaag
    30781 aaagaaacta tggaaaaagg tatgaaagta gatgaagttg gtaaaatagt gagaaaacat
    30841 attccacgaa gaagtatctt atctatagag tatgaagaag gattaagtag tgaagaaact
    30901 atggaacttt ccagaagaca aatagcaaat atattagaag ataatatatc tgtgttctat
    30961 ggtggagtaa gtggacttgt atctatagat aaatttttaa aagaagataa agttatttat
    31021 gacaatagtt ttgttactgt tgaaagagac ttatttgata taaaatcaca aaaacatata
    31081 acagaaattt catctggtga ttttatttgt atgacatata aagggcctta caaagaaaat
    31141 tataccgctt ttaagaaact ggttgattat gttgaatata aaagaatacc tattgaaaat
    31201 tatatatatg aaatacctat aatagaccct ctgtctacaa acaacgaaga ggaacttcta
    31261 acagaaattc aaatacaagt taaaaagaga gaaattgact taagatgtct agtgtagtaa
    31321 tctagtttac ttacacatct taatatagtt gtctattatc aacatatgat ttttctagat
    31381 agtgattcct aacagtgaga ttttcaaaaa ataggaggaa atatggctaa tgctaattcc
    31441 ctcctatttt taattaagcc atatcatttt aattaagcca tgtcatcacg aagtgcatca
    31501 ataatatttt ctttttttat cttattaata gtatacaaca ttgtaataaa tactataaat
    31561 aaaacactaa atatactaat tccaatacta aaccatggaa tcacaaaatc aatatcatct
    31621 gtaaccatta ctttatgaat tagccatgaa gaaattactg ctataggaag tccaaagaac
    31681 aatgctctca tgccataaaa ggcacactca aaattcatca tcttttggaa atcatgctca
    31741 gacattccta cagagcgaag catggcaagt tctctacgac gtaacttaat attagttgaa
    31801 attgtattaa acacattggc aatcgaaatc agagaaatca taattatgaa agtataagca
    31861 aaaacattgg caataaaaat gtaattacgg ttctcatcca tcattccata catattgtac
    31921 agattgtact cattcgtaac tccctcactc tcaataattt gctccatttc tgcaactgac
    31981 tgagtaggat ttttcgattg aaagcttaaa ctttcaattc ctgtagaaac accaggaatc
    32041 tcaaacttat ctttggctga ataaggagcc aatactctga agcttgcttt cttcacatct
    32101 gaacttctga ttcctggagg agaatcaggt ggcactactt tgacaaatga aatattcaca
    32161 ttttgtctct caggtatctc caacttgcca ttagtttcag gagtgaggct aacattcata
    32221 gaagaactgt tgaaaatatc aataatatta ttatcctttg ttaccataga aacagcaatc
    32281 agttttgcat tttgtccagt atattcttct gctggtaatc caagactttt aataatattc
    32341 agataagttc tatcatcaag aaattgcata tctactggta attcaagcat ttcactcata
    32401 gaatgtgaac cctcatagtt caaataatcg tctgtaagct cacttacttt ggcaacacat
    32461 gaataggtca taagtttctg atacaaacct tcgtaaacac catttgcagt ttttagctta
    32521 tcgtaaagct tcaacatttc gttgtctttc ataccttgtg tagaaaaaat aatatcctgg
    32581 tcagtaacct ctgacctctg atttgacatc tgttttaggt ctgctactaa agcacttgta
    32641 gatataaata gaactatgct taaaacaagc gacaatacaa tacttcgata acgtttcttg
    32701 tttcttttaa agtttttcat agcaagaact ccctcaagac cataaactcg ctgtgttagt
    32761 tttgatgtct tcacagattt agattcaatt tttacctcat ttgtctgacg aatacactcc
    32821 atcactggtg tgttggcagc ctttcttgct ggtatgtaag cagaaattaa gattgtaacc
    32881 atacttacca ctgctgcaac gatgattgca gggatagaca atgttaatgt caacggaacg
    32941 tttacataga gaatatttgc aaagttttta gatatgacag aaatcacaag tccaatactg
    33001 actataccga ttgcaacacc aattggtata ccaatcgcac caatgcaaat tccttcaaat
    33061 agcaccgaat ttcgtaactg ttttgctgta gctccaacag atgaaagtat tccaaattga
    33121 tgtgttcgct cgttcaatga catgttaaat gaattatata ttagaaaaat tgagcctagc
    33181 atgattatgg caagcacaat gccaccaacc gagtacaaaa acatattgaa caaattgtta
    33241 tcagagacac ctatgaatcg caacacattg tcattgaaaa tggaagcatg gtctttagtg
    33301 ctacttgtgt aagagcgaat ctgatgtgga tttttcaatg tgacaaaaag gctaagactg
    33361 tcagtcttga cttgtttatc ttctttggtt atcaaggtat atcctggtgc agaagattct
    33421 tcaaatacgg gctttctaca gatacccaca actgtataag ttttcttatc ctgtggcaca
    33481 aaaacttcac tcccagcagt gtatgggtca ctctgaccaa gcttttcatt ttcactcatt
    33541 cgtttcccta catccaaaga aatagtatcc cctactgcaa atttgacacc accatctgtc
    33601 gcaactttac ttgaaacaag aatctctcta ctattttcag gtaatcttcc agaaattaaa
    33661 gttataggca aagtatcaaa agcttctttg ctaaatccag caataaaaag atatggttta
    33721 tctggatttc tgttaccttc aagtgttgca tagccaatat tttcaaatgt tgcagtattt
    33781 gcaacttcat cattgactct ttgttcctgt acaaaagaag aatccacatc caaaaactgg
    33841 acatgccaat caccatattt tataatagct ccatttatca tatagttcat caaagaaact
    33901 ccaaaggtag taactgctgt aatcatagca gctgacagaa caactcctat aattgttaca
    33961 agagttcgag ttcgattctt tttcaatcct tgcagagcaa ctttgttaaa aatgttcatt
    34021 aacgattcac cttcctctca tcacgcacta cttttccatc tgaaatacag ataattctat
    34081 ctgcctgtaa agcaatgttt tcatcatgtg tgacaataat gagagtttgg tgatatttac
    34141 tatggctctc tttcagtaac tggataatct cttgtccatt tttactgtct aagctacctg
    34201 taggctcatc agcaagcata actgctggtg cattcatcaa tgcacgacca atggcaacac
    34261 gttgctgttg gccaccagaa agttgatttg gtaaatgtgt ttttcgttct tttaaaccaa
    34321 gtaattctaa caagtcattt aaccgttctt gattgacctt acgcttatcc ataagtatag
    34381 gcaatgtgat attttccact acatttaatg tgggtatcag attgtgaaac tgataaatca
    34441 atccaacttg tcgcctacga aaaatagcaa gtttttcatt gctttggcca tatacatctt
    34501 gcccctccag atatatcttt ccacttgttg gtacgtctac tcctgcaatg gaatgtagta
    34561 gtgtagattt accagaacca gaagaaccaa tgattgcagt aaactcccct ttttcaatag
    34621 taagtgagac atggtcaagt gcagtaacct tattttcatt cttaccataa accttacata
    34681 aatcttcaat ctttaaaaac gccattatat aagtctcctt tcatatttta taaatatatc
    34741 atagaacttt caacttacat ttaagtgaca tttaaatgag agattcgtca ctttggaaaa
    34801 cgaataacaa atattgcacc accttgtggg tgattttgtg cagtaattgt tcctccttgt
    34861 ctcataataa tcgtcttaca aagtgccaat cctattccat aaccggctgt gcttgaattt
    34921 ttcccacgat aaaatctgtt aaatagacat ggtaaatctt cttttttaaa gcctgctccg
    34981 ttgtcatgaa tagtaagttg agtaaacaaa aagttgtcct cacaaatgat atcaattttt
    35041 ccattatcac ccacactctc catgcagttt ttaaatatat tttgaattgc ttctgaaagc
    35101 caatttaaat cacccaaaat ccttactcct tttggtatat caatatgtaa agtgatattg
    35161 tgcagttcca tgggaatcaa aagttgatga agtgcagaac taatcaaatt attcacatca
    35221 atttgttctt tttgaaagac tacaatacct gcatctaaac gtgataattt taaaagggaa
    35281 gtaatcagcc agtccattcg tataagtaat tcctctgttt ctcgtatcaa ctcttttctc
    35341 tcatcttcat cagaagtatt ctctaacagt gacaaaataa gagttactga tgtaagagga
    35401 gtgcgaagct ggtgggctat gtcagctagt gagtcagcaa ggtgttcttt ttcttttttc
    35461 agtgcgtaat tttgctctct aatgcgtaac gtcattttag ttatttcact ttgtagaata
    35521 gaaagctcac cctcatctga ttcagcaata tacagatggt tagcattatg aagcacaaga
    35581 ttaatttgtt ctgaaatctg tgcaatactt ttgtatcgat ttttagtaaa cacaaaaaat
    35641 gctattccaa aggtagtggc agaaacaata gaaagtattc cagtcataat actgattgca
    35701 aatcccaggg ctacagtgag aatagtaatt aataagaata aaatagcaaa ttttcgaaac
    35761 tctctatttc gaaacataac ttccccccaa tctataccct gtcccacgaa cagtcaaaat
    35821 tatttgtgga cttgaagggt catcttctat cttctctcgc aagcgtttga tgtacacagt
    35881 caatgtgttg tcattaacaa actcacctgc cgcatcccac aattcatcaa gtaatcttac
    35941 cctcgtaata atacttttag gattgctaat aaacaccaat aacaaacggt attctaaagc
    36001 tgaaagaaaa acctcattgc cattcttttt cacaacacca gttgctgtat ctacataaag
    36061 cccacaaatt tcaaaagttg acccaaaacg cccacttttt cgtagtgctg ttctaattcg
    36121 cgcaatcagt tcacgtggac gaaaaggttt agtaatataa tcatctgcac ccatattcag
    36181 tccagtaaca acacttgatt catcaccgga agctgtcaaa aagataacag gaatgtcttg
    36241 cttttctttg atttctgtgc aaatcgtaaa cccatttcca tcaggtaaag aaatatcaat
    36301 aagtgccaaa tcaaatttat tcttagcaat ctctacaagt gcttcacttc ttgtggatac
    36361 atgggttact ataaatcctt ctgaattaag caaaagaata agatttttgg caattgcttt
    36421 atcatcctca actaaaaata tccgtttcat ttactttcat cctcctttat tttattagtt
    36481 ttatatattc cagcagagca atagtacact actattttac ttatcattac acaattttca
    36541 gtagtttctt ttgttcttat ataatccatg cataatacct ccattgattt attatatttc
    36601 ttataacata aatacacaag ataagacaaa aaacataatg taagtgcaag ttttttaact
    36661 cactaactta taaacataca ctcctactaa cactactttc ttgatgacac atcttacaag
    36721 cttatattca tacatcaatg aaaaattaaa tttatccatt tattaaaata aaaggcaata
    36781 gcttctatag ctaatgccct ttatcttaaa atgatttaaa tactatacaa tttttataaa
    36841 tggctataaa taaactcgta tagaatataa aatttatcta cagtcttttg ttatacaaaa
    36901 tttataacct cttatagaac aaatttacca ctttgcaaac ttatcacttt tactcagcta
    36961 tattataaac ttttaattta tctttgttta aatgtttctt cttaacttct actaaagctt
    37021 ttagcgtatc caaagatgtc attatttcag tagaaaattc aatggctgtt cttctcatct
    37081 taaatccatc tcttgtagag tcatttcctt tagttggtgt atttattact atatcaactt
    37141 gtttatttct tatagcatct aatatgtttg gtctaggttc ttcaattcta tttactatat
    37201 cagcctctat tccattttct cttaaactct tcgctgttcc ttctgtagca acaaaagtat
    37261 atcctaattc tttcatatct tttgctatct ctataaactc atctttatca tgattattta
    37321 cagtagcaag tactactcct ctttcatcag acatatgtct acctgctgcc aagaaccctt
    37381 tatataaggc ttcttctaaa ttttctccta cacctaggac ttctcctgta gacttcattt
    37441 caggtcctag acttacttca actttagata atttagacat tgagaatact ggtactttta
    37501 ctgatactaa ttttggctct ttgtaaactc ctgtaccata tcctaaatcc tttaatttag
    37561 ctcctaacat acacttagta gccaagtcaa ctattggtac tccacttact ttacttatat
    37621 atggaactgt tctactagct ctagggttaa cctcaattat atataattca ttttgaaatt
    37681 ctataaactg tatattaacc ataccaagca cattaaggtc taaagctatt tttttagtgt
    37741 attctactat cttttctttt atttcatcag atatattttg acttggatac attgttgtac
    37801 tatctccaga gtgaactcca gctctttcta aatgctccat tataccaggt atcaatatat
    37861 cttctttatc acatatagca tctacttcta tttctctacc agttagatat ttatctataa
    37921 gtactggatt tttatggtct ctatcaaatg catcatccaa atactgaatt agtttttctt
    37981 cgttataagt tatttccata ccttgaccac caagtacata agatggtcta actaatactg
    38041 gataacctaa ctccttagca atttcaacac cttcattagt tgtccataca ccttttcctt
    38101 ttggtctatt tatatctagt ctctctagta aatcatcaaa tttttctcta tcttctgctg
    38161 catctatatc tctaaagtct gttcccagta taggtatatt tttttcatgt aaaaacttag
    38221 ccaattttat agctgtttgt ccaccaaact gtagtattac accttctggt ttttcttttt
    38281 ctattatatt taaaacttct tcttctgtta atggttcaaa atacaactta tcagatgtat
    38341 caaaatccgt acttacagtt tcagggttat tgtttacaat tatagtttct attcccattt
    38401 ttcttaaaga ttttacacag tgaactgaac aatagtcaaa ttctattcct tgacctattc
    38461 ttattggacc agaacccaat actacaactt ttctcttatc actaactact acctcatcat
    38521 attgttcata agttgaatag taataaggtg atagagcttc aaattctcct ccacatgtat
    38581 caaccatttt ataaactggt tgtatattat ataaacttct caattcatat aatttttctg
    38641 ggcttatctt cattaagtca gatatacctt tatcagaaaa tccctttttc tttaattcat
    38701 gtaaatattc tttatctaag tcttctattt ttagaacttt taacttttct tcttgttcta
    38761 ctatccattt aaatttattt ataaaccact tatcaacacc agttatttct gatatcattt
    38821 ctactttata gcctcttctt atcatttcag ctaagtcaaa tagtctctca tcatcaggta
    38881 ctactactct agcctttaat tcttctaatg ttctaccttc tgatggagca tgaaccaatg
    38941 aatattttcc tgtttcaagt gatcttatac ctttaagaat agcagcctca aagttacttc
    39001 ctatactcat gatttcacca gttgccatca tcttagttcc taattttcta ttggcatgtc
    39061 taaatttatc aaatggccac tttggtattt ttactaccac ataatctaat gttggctcaa
    39121 aacaagcata agttttttta gttactgcat tttctatctc atccaaagta taacctaaag
    39181 ctatcttagc tgctactttt gctattgggt atcctgtagc ttttgatgct agggctgatg
    39241 acctactaac tcttgggttt atttctatta tcgcatattc taaactatgt gggtttaaag
    39301 ctatttgaac gttacatcca ccttgaacct ctattgcatt tattatgtct attgatgcct
    39361 ttctaagtag ttgatactct tcatcactta gagtttgact tggagcaaca actatactgt
    39421 ctcccgtatg aactccaact gggtctacat tttccatatt acatacagtt atacagtttc
    39481 catttccatc tctcattact tcatattcta tttctttcca accttttata ctcttttcaa
    39541 gaagaacttg tccaacagga cttagctgta gtccatgtga aagtatttct cttaattctt
    39601 cctcagtatc agctatacct ccaccagttc cacctagcgt atatgctggt cttacaacta
    39661 ctggatatcc tatcttattg gcaaactcaa gacctgcttc taaatttgta actatatcac
    39721 taactattac tggttgattt atttctttca ttacttctct aaataaatct ctatcttcgc
    39781 ccttttttat agattctata gatgttccta taacttttac attatattta tctaatatac
    39841 cagcatcatg taattctaca gctaagttta atcctgtctg accacccata cctgcaagta
    39901 aactgtctgg tctttctttt tctattattt tttctataaa ttctattgtt aatggttcta
    39961 tatatatttt atctgcaatt tctttatcag tcattatagt agctgggtta ctatttacta
    40021 atacaacttc aattccctct tcttttaatg cttggcaggc ctgtgttcct gaatagtcaa
    40081 actctgcagc ttgacctatt attattggcc ctgaccctaa tactaaagtt ttctttatac
    40141 tatctaattt aggcataact ctttctcctt atctaaacaa ttttcacagt tcttatcttc
    40201 atcatctata caatcaactt taattacttt attttatctt aagttcaaat ttactcatca
    40261 atacatctat ttaatacatc tatgttaatt aaaccaaact ttttgattta agttattctt
    40321 gttttttagt tagctattct aatgttgttt attttactaa ttctaaaaat ttatcaaaaa
    40381 tatagtcatt atcttttggt cctgggcaag cttcaggatg gtattgaaca ctgtatacat
    40441 ctagcttctc atgtcgcatt ccttcaacag tattatcatt taaatttata tgtgtcactt
    40501 tcatttgttc aggaacttct gaaacataat aaccatgatt ttgagaagtt ataaatactt
    40561 ttccttcttc taaatcttta actggatgat ttccacctct atgcccaaat ttaagtttag
    40621 cagtttttcc tccaagagct aaagctaaaa gttgatgtcc taagcatatt ccaactatag
    40681 gttttttacc aataagagct tttatatttt ctataacatc ttctaagtct tctgggtctc
    40741 caggtccatt tgacaagaat attaagtcag ggtttatact caatacatct tctggagatg
    40801 ttgtagctgg aaatattgtt atatcacatc cacgagctat aaatgatctt aatatatttc
    40861 tttttactcc aaaatccata acagccactt ttggaccatt tccttttata tgctctactt
    40921 cttttcttgt aacagttcta actgcttctg tatttgaaaa cttatccaat ttatgtttaa
    40981 catcttctaa tttactgtct tctaatgtaa ttataccttt cattgttcca ttatttctaa
    41041 gtatcttagt caaagctctt gtatctattc cttcaagtcc gataacttta ttttgcttta
    41101 aatattggtc tatatcaatt tcacatctaa aattacttgg agaatcactt ttctccctta
    41161 ctatgaatcc ctttacttga actttttcag actctgctga tgataaattt ataccataat
    41221 ttcctacaag aggataagtc atagtaacta tttgaccata gtaagaaggg tctgttaaaa
    41281 cttcaccata tcctatcatc gaagtattaa atactacttc tcctacactt tcttctaaat
    41341 atccaaatgc ctttcctata aaaactgttc catcttctaa tattaacctt gctttcatac
    41401 tacagtacct cctataattc tctttagaca aactaaagaa cattaactaa atataagctt
    41461 ttaaatatct atatctattt ttcactttta cattctagtt ttatacttat ttacatttat
    41521 tttttatctt tttctattat actacaaatt tcttaaaaaa aagaagttat ctcaaaagta
    41581 aaaactccta gaaaaaataa cctctttttt ttatttaata attaaattct taaactatac
    41641 aatcaactta atttctattc agctatattg taaactttta actcatcttt atttaaatgt
    41701 ttcttcttaa cttctactaa agcttttagt gtatccaaag atgtcattat ttcagtagaa
    41761 aattcaatag ctgttcttct tatcttaaat ccatctcttg tagagtcatt tcctttagtt
    41821 ggtgtattta ttactatatc aacttgttta tttcttatag catctaatat gtttggtcta
    41881 gattcttcta ctctatttac tatatcagcc tctattccat tttctcttaa gctattagct
    41941 gttccttctg tagcaacaaa agtatatcct aattctttca tatcttttgc tatctctata
    42001 aactcatctt tatcatgatt atttacagta gcaagtacta ctcctctttc atcagacata
    42061 tgtctacctg ctgccaagaa ccctttatat aaggcttctt ctaaattttc tcctacacct
    42121 agaacttctc ctgtagactt catttcaggt cctagactta cttcaacttt agataattta
    42181 gacattgaga atactggtac ttttactgat actaattttg gctctttgta aactcctgta
    42241 ccatatccta aatcctttaa tttagcccct aacatacact tagtagccaa gtcaactatt
    42301 ggtactccac ttactttact tatatacgga actgttctac tagctctagg gttaacctca
    42361 attatatata attcattttg aaattctata aactgtatat taaccatacc aagcacatta
    42421 aggtctaaag ctattttttt agtgtattct actatctttt cttttatttc atcagatata
    42481 ttttgacttg gatacattgt tgtactatct ccagagtgaa ctccagctct ttctaaatgt
    42541 tccattatac caggtatcaa tatatcttcc ttatcacata tagcatctac ttctatttct
    42601 ctaccagtta gatatttatc tataagtact ggatttttat ggtctctatc aaatgcatct
    42661 tgtaggtatt gagataattt ttcttcgtta taagttattt ccataccttg accaccaagt
    42721 acataagatg gtctaactaa tactggataa cctaactcat tagcaacttc aataccttcg
    42781 ttaagtgacc atacaccctt tccttttggt ctatttatat ctagtctctc tagtaaatca
    42841 tcaaattttt ctctatcttc tgctgcatct atatcatcaa aatcagttcc caatataggt
    42901 atattttttt catgtaaaaa tttagccaat tttatagctg tttgtccacc aaactgtagt
    42961 attacacctt ctggcttttc tttttctatt atacttaaaa cttcttcttc tgttaatggt
    43021 tcaaaataca gcttatctga tgtatcaaag tctgtactta cagtttcagg gttattgttt
    43081 atgattatag tttctatgtc catttttctt aaagatttta cacagtgaac tgaacaatag
    43141 tcaaattcta taccttgacc tattcttatt ggaccagaac ctaatactat cacctttttc
    43201 ttatcactaa caactacctc atcatattgc tcataagttg aataatagta aggagatata
    43261 gcatctatct cacctgcaca agtatcaacc attttatatg ctggttttat attgtataga
    43321 cttctcaatt catataattt ttctggactt atcttcatta ggtcagatat acctttatca
    43381 gagaatccct ttttctttaa ttcaagaaga tagtctttag ttaaatcttc aattttcata
    43441 acttttaatt tttcttcttg ctctactatc catttaaatt tatttataaa ccatttatct
    43501 atacctgtaa tttgttctat catttctact ttatagcctc ttcttatcat ttcagctaaa
    43561 tcaaatagtc tctcatcatc aggtactaca actcttttct ttaattcctc aatgcttctc
    43621 tcctcagatg gtgtgtgaac taatgaatat tttcctgttt caagtgatct tatcccttta
    43681 agaatagcag cctcaaagtt acttcctata ctcataattt caccagttgc catcatctta
    43741 gttcctaatt ttctatttgc ttttttaaat ttatcaaaag gccattttgg tatttttgcc
    43801 accacataat ctatagttgg ttcaaaacaa gcataagttt ttttagttac tgcattttct
    43861 atctcatcta aagtataacc taaagctatt tttgacgaaa ctttagctat tggatatcct
    43921 gtagcttttg atgctaaagc tgatgaccta ctaactcttg gatttatctc tataactgca
    43981 tattcaaaac tatgtggatt aagtgcaaat tgaacgttac aaccaccttg aacttctact
    44041 gcatttaata tatctaaaga tgctttttta agcattgcac attctttgtt acttaaagtt
    44101 tgagttggag caacaactat actgtctcct gtatgaactc cgactgggtc tatattttcc
    44161 atgttacata caactataca atttcccttt gaatctctta ttacctcata ttctatttct
    44221 ttccaacctt ttatactctt ttcaattaat acttgtccaa caggacttaa ttgtagacca
    44281 tgtgaaagta tttctcttaa ttcttcctca ttatcagcta tacccccacc agttccacct
    44341 agtgtgtatg ctggtcttac aactactgga taaccaattg taagtgcata atcaagacct
    44401 gcttgtaaat ctgtaactat atcactaact attacaggct gatttatttc tttcattact
    44461 tctctaaata tatctctatc ttcacctttt ttgatagatt ctactgaagt acctattatc
    44521 tttactccat atttatctag tatgcctttt tcataaagtt caactgctag gtttagccct
    44581 gtttgtccac ccatacctgc aagtaaactg tctggtcttt ctttttctat tattttttct
    44641 ataaattcta ttgttaatgg ttctatatat attttatctg ccacttcttt atcagtcatt
    44701 atagtggctg gattactatt tattaataca acttcaattc cttcctcttt caaagactgg
    44761 caagcttgtg ttcctgaata gtcaaactct gcagcttgac ctattattat tggtcctgac
    44821 cctaatacta aagttttctt tatactatct aatttaggca taaatttttc tccttatcta
    44881 aatggttttt actatctgta aataatacta aatctatatt aatgctaaga atttattaaa
    44941 tatacaatct aaatcttctt ttgttgtgta ttctggaatg tattgaacac tatatattgg
    45001 taattcctta tgtctcattc cttctatagt attgtcattt aaatttatgt gagttacttc
    45061 tgtattttct ggcatttctg aaacattata tccatgattt tgagaagtta taaatacctt
    45121 tccagtttct aaacatttaa ctgggtgatt acctcctcta tgtccaaata caagctttga
    45181 agtctttcct cctaatgcca atgctaaaat ttgatgtcct aaacctattc ctgtcaatgg
    45241 ctttttgcct attaattttt ttatattttc aactatatca tttatatcct ctggatttcc
    45301 tgggccatta gataataaga ttaagtcagg atttatattt aaaatttctt ctactgtagt
    45361 cattgctggt actatagtta tatcacagtt acaagcctta agagactcta gtacactatt
    45421 tttaacacca aagtctataa ctacaacttt agctccagta ccttttatat tttcaatttc
    45481 ttttcttgta acatttttta ctgaatcttt gttacaatgc tcttctaatt tagactgaac
    45541 atcttgtaat gatacatttt ctaaagttat aattcctctc ttagttccat tgtttctaat
    45601 aattttagtt aatgctcttg tatctattcc ttcaagtcct attaccttat tttgctttag
    45661 atatgtgtct atatccattt cacatctaaa attatttggg ttatcacttt tttctcttac
    45721 aataagtcct tttacttgca ccttatttga ttcaacatct tctaaattta ttccatagtt
    45781 tcctataagt ggataagtca tagtaactat ttgtccataa taagttgcat ctgtcaatag
    45841 ttctccatac ccagccattg aagtattaaa tacaacttct ccaatagctt cctttagata
    45901 tccaaatgct tttccttcaa atactgttcc atcttctaaa attaatttcc ccttcatgta
    45961 agctacctcc caaatatttt atctaagcat tttctatttc tcttacaata ttaatagctg
    46021 attctcttgg attttctgct tttgttatag gtcttccaac aactaaataa tgagcacctt
    46081 tttttattgc atctgatgga gttacaactc ttttttggtc tccaacctct gctgatttag
    46141 gtcttattcc tgggcaaact gttataaaat cagttccaca tgcttctact attttatcta
    46201 cttcttgcgc tgaacaaaca accccatcta ttcctgattc ttttgccagt ttagctctct
    46261 ttatagctaa ctcttctgtt gtcatattac atcctatgtc ctgtaaatct tggttgctta
    46321 atgaagttaa aactgttact ccaactacta atggcttttc tatatttaat ctttctgctt
    46381 cttccctagc aattagtgca cattgtctca ttccttccat atctgataca tgtattgtca
    46441 ttaaccaaac attatctctc actgcagctt tcactgcact tttcatagta tttggtatat
    46501 catggaattt aaggtctaaa aatatttttt tccctttttc tttaagataa tctattgttt
    46561 taccttttgt ggcaacgtat tgctctagcc ctaccttaaa tatgtctaca ctatcttcta
    46621 atctgtctat tagttcttta gctttatcaa attcgtcagt atcaattgca actatcaatt
    46681 tttctttacc atttatcatt tttacatctc ctttttaata aagcctaaat aatcataaaa
    46741 aaatcctcac accaaaagag gcataaggat tttatctata cataactcta ttcattagct
    46801 atgagatatc tttcccagtc tctctggact agtttaaaag actttattat atttaaattt
    46861 ttattttata ctcatcaaaa acctctagaa gatttactag aggttatata ctaacattat
    46921 ctataaccct ttagtctctc tggactactt taaggaattt agctgtaata tttttcttta
    46981 tttatataac tttatgtatc tataggataa tttaaagttt tatctttttt ataattaaac
    47041 cactaattgc tttttatgtc aataagtctt tgaattattc ttcatcttta tcaaacaatt
    47101 ttttctcaaa atatgattct gcattatata ttgcagcaac tggattatgc ccagttactc
    47161 tatctttgac aactaaagtt gttataggag cttccatata tttcatggct aaagtatcgt
    47221 gaccaacaca taatccaaga attacattaa ggtcaacctt agcttcattt aaaaataaag
    47281 cttgtcctat tggattgcac attacctcat ctgaacactt tgatattgtt tgagatgctt
    47341 ctagtccaat tgtactctta ggcattgccc catttttaca tataacagaa aatacttcaa
    47401 acccatgatg ttcaaatatt ttttgcactg tttgcatttc tctttttagt ccaatacaaa
    47461 atgctatgcc aatcttttta taaccacact ttttagcaaa ctctataatc tcttttagtc
    47521 tagtatattg acaatacccc tctgcttcaa ctaatccagc attataagct atttttctat
    47581 tctcttcttc ttcataaagt tgctttgctt tttgttgtag ttcaatttct ctagttggac
    47641 atatcttcat taatttatcc atatttccat tagaacagcc tctaagatta cattttccac
    47701 acttatacat atccaatatc cccttccaaa attttattca tcttgcgatt cttctttttc
    47761 tagagttaca ttttcttctt gggtttcttc ttctggtttc acatgctcga ctacagttat
    47821 aaaatatgat tttcctattt tattccttat aggaagtttt tcatatgaaa catctatttt
    47881 attttttata caagctatat caaaatgtct taaggctaca cctaagctaa ccttattcat
    47941 atcttcacag tgtttcttag gtctcttttc aaataaatga agacctcgtt catccttatg
    48001 gaaataccac ggttgagaat tttttacaga tggagctctt cttgtcaatt ctaagatatc
    48061 tttccacttt ctattcctat ttatcttatt tatcatatct tttactggct ttctatcagg
    48121 tctagcatat ctcgtcctaa acaactcttc attttttgct ggatatccaa atgctattat
    48181 tatataagga ttttctattt tgttttcatc atcttcttct gtttttattc cagctagata
    48241 atctaaatca tcttcctcat cttcttcaaa attcttattc ccaatatcta caaattccaa
    48301 gatatcttct ctctttaagt ttccttccaa ccagcaagta gctattccca atgttgtaag
    48361 gcgcaaaact acaccttctg tagcaaatcc tatattctgt aaatagtcct cacctttgtc
    48421 tgatgtaact actatataat gaggtgcctt tactttacat tccttcccca tcaaaaaatg
    48481 tattatatga cctctatcaa caacatgtgc tttaatattt aaatcttcat ttaagtattc
    48541 taaattttta caacttcttt ttatttcttc catcaatggc ttttttatct ttttactgga
    48601 aaaatttctt acagattttc tataaaaaat ggcttcataa agctccattt atgccctcct
    48661 aactgaaatc ttctgacgta taaactctat aaatttatat aaatacttta tattttttat
    48721 agttttattt cctttttcct cctgccctat tttgaaattc ataagaatat ctactctagt
    48781 ttaatatagc attcaaaagg cttaaattct accttatcaa tgtctataca ttagcataat
    48841 ttttttattt gattttctat gctaatttaa ataacaacac tagctattac ctttttaatt
    48901 aagctttgcc agaaaaattt tttttcattt ataaatatct atctcattat tatattataa
    48961 gtttttttcg gtattcttgt atagcttttc actaaaaaag tatttttatt tctactttaa
    49021 tattattatc aacaaaaaac atactactta aataagtttg ttatcctcat aatttgtttt
    49081 aattaaaata ttttttttat ttctcaatct ataaagtata aatattttga atatgaccca
    49141 aaatctaagt aaagttataa tattttataa gttgttcaat attaaaaaca taagtaatgt
    49201 tataatactt tataagttat tcaatattaa aaatatagga ggataaatat gaatttaaat
    49261 agaaatttag aaaaatacgc tgaattagca ataaaagttg gagttaacat acagccaggt
    49321 caaattctac ttataaagtc accaatagaa tgtgctgatt ttgcaagaaa tgcacttaaa
    49381 gaagcatata aatgtggtgc taaaaatgtt tatatagagt ggtctgatga agaaagtact
    49441 cttattaaat acttatatgc tccagatgaa gcatttcatg agttccccaa atggacagca
    49501 gaacaatatg tagatatagc aaaagaaggt ggggcatttt tatcagtcta tgcccaaaat
    49561 ccagatttat taaaagatgt tgaccctgaa agagttgcaa attttcagaa ggcatctgga
    49621 aaagctttaa aagaatggcg ttcttacact ctaactgata aatgtaaatg gagtatagtc
    49681 tctgtgccaa caaaagattg ggcaaaaaaa gtgtttccaa atttatcaga agataaagca
    49741 atagaaaaac tgtgggatgc tatatttaaa tgttcaagag tagatggtca ggaccctata
    49801 aaagcatggg aagaacataa tgaaaatctt aaatctaaaa tggactttct aaataaaaat
    49861 aactttaaaa ctttaaaata taaatcctca aaaactgatt tgactctaga cttgccaaag
    49921 ggtcatgttt ggctaagtgg agcatccaaa gaccctaatg gaataagttt taatccgaat
    49981 attccaactg aagagatttt tggaatgcca cataagttta aagtaaatgg aactgtttat
    50041 agtacaaaac ctcttgttta tggtggaaac ataattgaca atttcttctt aacatttaaa
    50101 gatggtaaaa taatagattt ctctgctgaa aagggactag atacactaga aaaacttatt
    50161 gaaacggatg aaggctctca ttatttagga gaagttgctc ttgttccata caactcacca
    50221 atatccaata cggatataat tttttataat actctatatg atgaaaatgc ttcttgccac
    50281 tttgcaattg gttctgctta taagacttgt ctggaaggtg gaaacaattt aaaagatgaa
    50341 gaattagatg aacatggtgt aaatgacagt ttaacacatg tagattttat gattggttct
    50401 gctgatatgg atattattgg tgagacttat gatggaaagc aaatacagat ttttaaaaat
    50461 ggtaattggg ctttttaaca tatgatttta actaaaaagg gctgatggaa gttataccag
    50521 acttcccagc cctttttaat gttgatgata aatatttttt atattaatta atctcattat
    50581 tatagattaa ttcctattgt tttaaacata agtatctaaa acttatattt atattatata
    50641 taaaatatcc tatttagtaa aacctttatt ttaatttata tgctaaaaat ttaactttgc
    50701 tatttcaaca gcagactttg catcctttga ataataatca gcacccattt cttcagcgta
    50761 ttcttctgtc aaaactgcac ctcctacaaa tacctttgca tttatctcat tatctctcag
    50821 tgcctgaatt gtatctttca tactttgaac agtcgtagtc ataagtgcac ttaatcctac
    50881 taattttata tttctctttt tagcaacttc cactacttct tcaataggga catctttacc
    50941 taaatctata acttcatatc cataattttc tagcattatt tttactatat ttttcccaat
    51001 atcatggata tcacctttta ctgtagcaac tattattttt cctttggata cattattgct
    51061 acttttactt aataaagttt cctttattgt atttaatgaa acttttaccg tttctgctga
    51121 ttgaatcaat tgtggtaaaa atatatctcc actatcatat ctttttccta ctttatcaag
    51181 agcaggaatt aaaatctcat ctaatatata attttcatcc ttctctttta aaagattcag
    51241 tgttacattt tttgcttcat cttttaatcc tctttcaact aaaatatcca agggcaaatc
    51301 tttatcaatc tttgtagatg aatccgattt ttttgaatta tttatattgc tatattgatt
    51361 tatatagttt atacatcctt tatctgtgtt atttaatatt ttaaaagaat tgatagcttc
    51421 catcatacta tattcatttg gatttataat tgctaaatca agccctgccc ctaaagctaa
    51481 tgttagaaaa gaagcattaa gtgctttcct atttggaaga ccaaatgaaa tatttgaaac
    51541 acctaatata gtttttactc ctagtgtctt taccattgtt atagctttta tagtttctat
    51601 tgcttcttct tgttgtgctg aaacagttaa tgataaacag tctataaata tatcttttgg
    51661 ttttatccca taagaaactg ctctattaac tatccttttt gctatttcaa atctttcttc
    51721 agccttttta ggtatcccct tttcatcaag tgtaagtcca accacacatg aaccatactt
    51781 tttaactatt ggtaatatac tttctaaaga ctcctctttg ccatttacag agtttactat
    51841 tgttctacca ttataatatc taagtccttg ctctaaggcc tctacattgg aagaatcaac
    51901 ttgtaaaggt gtatctacta ctgcttgaat ctctcttatt aattttggca ttagtttttt
    51961 ttcatcaatc tctggaagac caacatttac tccaagtatt tgtgctccag catttacttg
    52021 ttctaaacct aaatttatag cataatcaac attttcattt tttaatgctt cttgtagaga
    52081 ttttctacct gtgggattca atctttctcc aacaactgta ggcgattgta cttccacaaa
    52141 ttttgatggt gaacagacta cacatttatc aattttctcg atacatccct ttgtaacaga
    52201 atttatattc tcagatattt cttttataaa acttggattc gtaccacaac atccacctat
    52261 tatagtagca ccaacttcaa cgaacttttt aaccccttca aaaaattctt ttgcatcaac
    52321 atcatatata gcctctccat caactatatt tggaagacct gcatttgctt gaaccataac
    52381 agggactgta gctcttgatg ctattttttc aactattggt aaaagttgtt taggtcctaa
    52441 tgaacaatta actcctattg catctacacc tagaccttct atagtagcca ccatacattc
    52501 tggcatacat ccagtaaaac ttcttccacc ttcatcaaat gtcatagtac agaaaatagg
    52561 taaatcagag ttttcttttg ctgctaatac agctacttta gcttcatata aatccatcat
    52621 agtctctatt actattacat caactccaga tttaacgcct tgtagtactt gtcttttaaa
    52681 tatttcatat gctttatcaa aacttaaagt acccataggc tctagcattt ctcctatagg
    52741 accaatatct aaagctacat atcttggttt agtattatct acattttcta tagcttttct
    52801 agccaccaaa acagcattgt caatcacttc ttctacagta tacttactat ctaattttag
    52861 ttcattacat ccaaaagtat ttgtaagaat tacattcgaa cctgcctcta agtatgctgt
    52921 atgtatttct ataagtttat ctggattttg aagaccaaat acttctggat tttcacctaa
    52981 ctttaaccct ttttgttgaa gcattgttcc cattgcacca tcaaatatta atatattatt
    53041 tttcagatat tgtcttattt ccacaagagt tcgctccttt tctatatgta cagtttctat
    53101 agtttttaca attttcacac gacttttctt tcttagattt atttattctt gtattagaaa
    53161 tacctataat agccactact gactttctcg gtatcataat tccattagaa gtaattgtta
    53221 gacctatttg tttttgagca ttcaaaacgt ttaatatatc tatatttttt tctattggta
    53281 aatctccata tcctgggcta tatcgcatag ttataaattt atcttgcttt aaaaaaacct
    53341 tttctaaatt attttgaaca atgtcacaca cttcttctat tgctgttgtt ccacatgaat
    53401 caattattag tccttttgtt aaatttgaat aagagtgtcg tcttatttct ttttctatat
    53461 ctatccctat agtagctgcc ataattacac actcattaca ttcttttaaa agttcatata
    53521 catctttact ctctaatgtt aaatttgttc cctctaattc tacaacatta tctttattta
    53581 ttttaatagg ataaatccta gataaatatc taggatttat tttattttta gttatagcta
    53641 cacattcatc aatagtatat ttaaggtctt tatctatctc ttgacctcta tattgtaaat
    53701 atcttaaaac ttcactttga tttatgctta tatcttctct tccaattaaa ttattctcca
    53761 tatatattta aagaaaatcc tttatctaaa acatcttttg catattcctt tgccccaaat
    53821 aaagataagt ctctgtagtt tccacattct atagctgtag ctgctggcat tttatctgat
    53881 tcaagaactt tttttaatgc ttcttctaaa ccaatcttaa ctgttttggc atctacatct
    53941 ccccatagta ttaaataaaa tcctgttcta catcccattg gagataagtc tattacacca
    54001 tctaatgtat ctcttaaata agtagctaaa agatgctcta aaccgtgcat agcagcagtt
    54061 ccaaaacttt ctacatttgg ctgtaaaaat ctcaagtcaa atttagttac tttatctccc
    54121 tttactccat caagtacact acactttctt acaaaaggag cttttacttt tgtatggtct
    54181 agcttaaaac tttctacttt ttccattatt taatcctcca ttatacttta aaatttgtta
    54241 cattaattct aaaaaaaact cttcctatct attattgata agaagagtat attatttcaa
    54301 gtcatctcat cgttgttagc aggaccacct gataaaaggt tggtatagga tcactgagct
    54361 aactctctcc cctaactctt gataagtatc ttattaaact gacttaaatt atatattact
    54421 tttttatttt tgtaaacact ttattgttat aatatttata tcacataatc gtacttttat
    54481 tttataacta agctgattgt attattggca gttgtacttc aaacacagtt tgatatttat
    54541 cgcttgaaac agtaatttct ccatcatgta aatttacaat attttttgta atcgcaagac
    54601 ccaatccaga acctccaaca tttctatttc tcgatttttc aactctataa aatctatcaa
    54661 atatatttgg taaatctaac actggaattg gttccccata atttatcact tttacaaccg
    54721 ccatatcttc ctttttctct gtgactatat ctacataatg cccatctttt ccatatttca
    54781 cagcattagt tataagattt tcaaatgctc ttaccaattt atttggatca gcttttacaa
    54841 ttaatttttc ttcattaaaa ttaattctac taaccataaa ttcttgttta aaataaattt
    54901 caaattgaga tactacttga cttaataact ctactaaatt tatttctatt ttgtttaatt
    54961 ttattgtatt attttgcatt ttagtcaatt caaacaaatc atttataaga acatttaaat
    55021 ttttcgattt ttcatatgca atatcaacat aatacatcat ctgaacttca tctttatact
    55081 taccttcttc tatcactcct aaataaccca ttatggatgt caaaggtgtt cttaagtcat
    55141 gtgacacatt tgttattaaa tctgtttttg tctgctgagc ttgtctctct tcaatagtta
    55201 tatttctaag ttgatggact atattattga ttttatgtgc tagttcatca atatcatcct
    55261 tttctttatc ctttaatata tctaaatcat actcaatatc tatacttttt tctaagttac
    55321 cttcatccat taaatttaca gcacttttaa tgatttctaa tttttgattt tttctattag
    55381 tctttcttat aaaatctaca atttgcttat ttctcttgta cgatatcatg gaataaattg
    55441 ctaatgatgt gattgtaaat aaaaatggat aaaataaatc ataccctata agacttctga
    55501 aatctcttgc ttgatataca agttgattaa ctacagacat atcactattg acatataatg
    55561 attttattat atacatactt gttaaaataa gcattgaagt taaagcacag cttattataa
    55621 gatctaatat gggtcgaaac atatgattta ataaactttt atttttcaat tttatatcct
    55681 actccccata cagtatgaat tattttttct ccatctgtat atttttcaat tttatccctt
    55741 attctgctca tatgaaccat tacagtatta ttagattggt aatatttctc tttccatacc
    55801 ttttcaaata tttcttctgt actatatact ctgcctttat tatttgctag taaatataat
    55861 atatcaaatt ctcttgatgt caaaattatt tcatttccag ccactgttac actatgtttt
    55921 tccttatcta taattactac tccaaccttt atgacatctt tatcttcatt attagcacca
    55981 ctaaaataat atgctcttct aatcagcgac ttcactctca cagtaagttc aagtgggtta
    56041 aatggttttg tcaaataatc atctgcacca gtcattatcc cttgtatttt atccatgtct
    56101 tctgattttg cacttaacat aagtattggt atattcaaac tttctctaac ttttctacaa
    56161 acttctatcc catccatttt aggcatcatt atatccaata tcattaaatg aatattttcc
    56221 ttttttaaaa tatctagagc ctcttttcca tcttcagctt taattacatt atatccacta
    56281 tttaaaagat atatctctat aaggtctctt atttcctttt catcatccac aacaagaact
    56341 gtattattca tttttacaca tcctaactta atctttgtat atagctttat tcatataaaa
    56401 ttatactata ttttagttag tgtaatctat aaatttatta atttctaaat ttccaatata
    56461 atacaaatta tttacacatt tatattattt attttgtaaa tattcttcta aagttaatcc
    56521 ttttgaataa atttcctcgg cagcatcctt accaacatat ctaatatgcc atggttcata
    56581 tgctgtacct gttatatctt ctttaccttc aggatatctt attataaatc caaacttgtg
    56641 agcattttct gccaaccatt tagcttcttt tgtacttcca acaaaccatc tttctggatt
    56701 tgttaaatca atacaaagtc cagtttggtg ctcactgtaa ccaggctttg ctacatacgc
    56761 atctgccttt tctcgcccct gagattttac ccttcttgta taagtatcca gttgagtatc
    56821 ataagatctg tatgctgaag accctaaaaa ctgtattcct tctgaattag cttgcttaac
    56881 taaatcttca actgcctttg caggttctcc tgccatttgt ttttcttcct ctgttgcttc
    56941 ttcaacaaaa ggtatgttta ccttagtaat attttcagga gtatagtttt tgctaattcc
    57001 atttgtcttg tttaccaata atatatttga tatactattt gagtgatttt tattttgaga
    57061 atttgcctca acatcttgtt ctgaatcatg ttgagcagct actattggat ctttatcttt
    57121 cttaagtaat ctatctttag atataaatac acttataaat actactaaaa taatggctcc
    57181 tattaattta aattttttca taattaaatc ttctcctttt tgttatgttt gctataatgt
    57241 taattttaga gtataagact taagtatttt ataagtaaat cttaaataaa tcttaaattt
    57301 aatattttta aaggatggtg ataaaatgtc tatacaaaaa cttctaagta aagctcgtaa
    57361 ggctatacaa gattttgata tgatacaaga aaatgataaa attgcggttg gactttctgg
    57421 tggaaaagat agtttaactc tacttcatat acttaaaagt tatcaaagat tttctccaca
    57481 aaactttgaa ttgatagcca taacattaaa tactggaggt gttgataatt ctccactaga
    57541 taaattgtgt aaagaaataa atgttccttt ttatgaattt caaactgaca taaaagaaat
    57601 tgtatttgat ataagacaag aaaagaatcc ttgtgcattg tgtgctaatt taagaagagg
    57661 tgctttgaac gataatgcta aaaaacttgg atgtaataaa gtagctcttg gtcatcataa
    57721 agatgatgca attgagacat ttttaatgtc tatgttttat gagggtagag taaattgttt
    57781 ttccccaaag acatacctag acagacagga tttaacagtt ataagaccta tggtttacat
    57841 agaagagtat atgactaaga aaatttcaaa agattctaac tatcctatta tcacaaatcc
    57901 ctgccctgca aatggtcata ctaggagaga gtacataaaa aatcttattg ctaatttaaa
    57961 taaagagatg cctgatttta aaagaaatgt atttggtgct ttaaataatt ctgagaaatt
    58021 gtttatatgg gataaagaga agataaaaaa ttttaaataa taattaaaat ttttaaataa
    58081 aaaagcaaga ttgtattaat tgtaaataat ctttatataa tctacacaat cttacttttt
    58141 tatttattat atgttattat ctttaatcta tattttaata gttcttaata gtatttattt
    58201 tgtctaatac attaattata acttaaatat tttatatatt aatttaatct attaattcat
    58261 tcaatctact ggtttaatcc atttttacag tatatacatc tacatattat aaaaagcaaa
    58321 attatatttt ctaaatattt tatgttagat tataatatta aattctatta tctctggtat
    58381 attaaaaaat ctaaatggta actttgtact tccaagaccc gaactcacat ataaatgatt
    58441 tccatttatg tcataaaacc ctttagtata tttccttcca tatggaggag taactaatgc
    58501 tcccttaata ggtaatctta tttgaccacc atgactatgc ccagatagaa ctaaattcat
    58561 tgtatcttta ctaagcatat ctactaaatc tggttcatgt gctaacaata aattaaaact
    58621 tttattatct atttgactct ccagatattt tatattagga tttccattta atatttcatc
    58681 aacacctaat atattaatat atttatcatc ttttaatttt atttttttat tttcatttac
    58741 taaaagattg aagttggaat ttttcataat ctgcctataa tacctaggaa gtttatacat
    58801 ataatcatga ttgccaaata ctgaaaattt tcccaaccta gcattcatac ttgataaaat
    58861 agttgtaatt tcatctacac ttggattttt attggagtaa tcaattaaat caccagtaaa
    58921 tactattata tctggattca aagtgttaat cttattagct acttttttga gattcttagt
    58981 tgaataaaaa ctacctattt gagtatctga aatttgaact acttttacac tttcagattt
    59041 actctcaatt gaatcatttt ttatcaatgc tccattttca cttatattat attttttcac
    59101 aattaataga ctcggctcta tcgcaactga gtatataaaa atcaaaataa atattaagat
    59161 aaaaaatttt aaaaaatact taatttttga gttcaaaata tctacctact tatttatttt
    59221 tttaaactat ttgcattaca gactcaactt tgttcatttt tctgtcatgc atttttggct
    59281 tatttgctga aaaccattta tatgttgctg taagaccttc ttttagtaac acgtttggta
    59341 tataaagccc atgttcaata agcttattta tatcaagatt aaagtctata tttctaaatg
    59401 ggaaatacgt tctttctcta aactctactt tttccatatc tacatatttt attataggtt
    59461 ctttgccaat aatttctcca catgtatata taaggtcatc ccaagaaatt aactgtggat
    59521 ttgtcacatt ataggcctct cttacatgag gatttttcat tatgctttcc aataccttta
    59581 ccaaatcccc aatatatata aattgattac taacttgttt tccttttggt actggtatct
    59641 tttcattttt ttctattttt tcaaagaaat aatactctct atataaatta ttattttcac
    59701 catatatgta agttggtcta ataattatat atggtatagg gctatttata ataaaatctt
    59761 cagcctcttt tttatttaac ccatattttc cccagttttc attttcacct ttctcatttt
    59821 cttcttttat atttcttcca ctatctttat atactgctcc tgctgacaat actatatact
    59881 tttttaagtt atccatgctt ataaaatcaa tcagattact tacatcttct tttgtatatg
    59941 ctgtcatatc atatatgtaa tcatattttc ttcctgtgat aatgttttcc atatcttttc
    60001 gaacttttct atcacaaatt agatgttctt taaaaccatt ataatctatt tcctttttac
    60061 catttgtaag tatatcaatt tgatacccac atttaatcaa gcgcttagca agtgcagaac
    60121 ctatgaagtc gcttccaccc ataattaaaa tagatttcat tttaagtgca tcctcctctt
    60181 ttttaaatga cttccttaac tataatatca tatttttaaa tatgcgacac cattttgtaa
    60241 tatttttgtc tataaaagat atttataaca aaatatcttt tatagactct acattttcga
    60301 caatataagt aggttcactt tcactaatct cttcaaaaga accataccca tacaatactc
    60361 caatagaatc tatacctatt tttttagctc caattatgtc atactttcta tctccaacca
    60421 taataacttt atctttatct tttacattac ataggtctag tacatattgt ataacttcat
    60481 ttttattcac tcttgtacca tcaagattgc tacctgctat atatttaaaa tatctatcta
    60541 tatcaaaata tctaagtata gtttctgcaa aaactgttgg cttagaagtt gctactaata
    60601 atattttacc atttttatag agcatttcta atatctcttt catattctca taaattttat
    60661 tttcaaatat ccctttatca gcaaaatatt ctctatactt ttcaacagct tctttagctt
    60721 ttttatcttc aaatttataa tactccttga aagtatcatg taatggtggt cctataaatt
    60781 ggtctaagtt ttccaaatct tcttttatgc caaagctatt taaagaatac tgaatagact
    60841 ttgttattcc ttctttaggg tctgtaagtg ttccatctaa atcgaataat actatttcat
    60901 aatttttttt catatttcag tcctccatat ttgtaaaagg taatatctta tatattaagt
    60961 ttatctattt taaaaagcta tagtaataga aatttctaat actatagctt aagtaccaat
    61021 taaatcttat atatttattt taaaaataaa tttaaacagc tctatttaac tgttatagct
    61081 gaaactggac atccttcttc ggcttcttta cataaatctt gtaaatctgc tggtatttct
    61141 ccttcaattg ctactgaatg cccttcatcg ctcatactaa aaacgtctgg acatgttcct
    61201 atacatgctc cacaagctac acatacatcc ttatcaacaa atgctttcat actaaaatac
    61261 ctcccctaaa attattattt tttaattgtt gtttccttag atatttatcc aatatatacc
    61321 aatttaaaca tatatttatt attttatcac tattgtttag tttattatag tattttcgta
    61381 tccatgtcta taaacttcac tgcttttcat ccatgatttt acagtatatt gcaatcttaa
    61441 ttttttattt aaaacaagtt cattattatt gtagtctttt ataatatcat tacactcctc
    61501 cattgtaaat attgtaaaat caccttctcc accaatcttt attctgcctt tatttccatg
    61561 taaatcgaaa atctttgttg ggtattcagt tactttttct atacactttt ctagggatat
    61621 cccaagttcc ataattttat ttataacatt taaaagagaa tagtttacgt ctttcatgtt
    61681 ttttatatgc atatcagtac ttattaggtc aggctctaaa ccttgcttta ttgctttttt
    61741 aaaaacttta aaatcaaatt ggtccactcc atgacataca tcaaacaata ctcctctatt
    61801 ctttgcattt attactgatt ttcttaatgt gccagattct ttaaggattc catttgtact
    61861 atttccatat accggtgtaa ccacatctcc ttttcccaaa atattcatta cttcatctat
    61921 atatgatgga tactctccta tatataccac taagggtaaa tttaattttt tagcaacttg
    61981 ctttgatttc ttaattatat ctataccact ttcattagat tgaaatttac tcgcttttac
    62041 ttttataccc tttatctttt ctatattttt ttctacaatt gactcaacct tgtcaaaatt
    62101 tataacatct aaataagttg attcattcaa tatatttagt ccctcatttg taacatttaa
    62161 aaaagaatat acttctgttt tacactcatc catatacttt tttttaaaat catagtagtt
    62221 tgagggacca gctgtacctg catcaaatat aactgtagaa cctttttcaa ttccaattga
    62281 atcagaatcc atacctgtag gtaattttct cttataacaa tgggtgtgaa catctataaa
    62341 tcctggggaa atatacatat tatcggcatt tattatctcg aactctttat ttgtaagtaa
    62401 tttttctttt cttattttct ctttaaggtt caatccaata gcatatattt tcccatgtaa
    62461 aaccaagata tctctttttt caaatttgat accatctgtt ggagatatta ttgtcccatt
    62521 tcttataagt aaatttttca tttattccac atcctaatta caatataatt tctctaatag
    62581 cttttcttac ataaagaaaa taagcctaaa aataaaaata ttttagactt attcactata
    62641 ttatactata ttaattatat taaattaaat aaaatcttta atttacttta agaagcaatt
    62701 aagtatttgt tgctcggctt cttcttcagt aagacctaat gtcatcatct ttagtatttg
    62761 gtctcctgca atctttccaa tagctgcttc atgtactaaa agagcatctg gatgatttgc
    62821 agcaatttca ggtatagcac taatttgaga atttcccata attattgaat cacattgaac
    62881 atgtgcagaa caaagggaat ccccaataac acaaggatta aacttttgct tagaattatc
    62941 ttgcccaact gtacgagaaa ctacttgagc agaagagttt tcaccctcta agataacctt
    63001 catattagat tctgcaactt gattaccatg agttaataat ttctcaaata caactatttt
    63061 agctccttta cctaggtttg catccatttc tcttttagtt gaatctacac ccttaatttg
    63121 aattgtttcc atttcacaat atgaatcctc atccatattg acaatagtaa ctggatttaa
    63181 aattctcttt ccttctccat caccttcacc ataatgtttt tctacatatt ttagtcgagc
    63241 tcctttacgt aagaaaaatc tatgtatacc attatgttca ctatcatcac aaccacagtt
    63301 atgtatacca cacccagcaa ttataacaac atctgcattt tctccaattt caaaatcatt
    63361 atataccata tcctgtacac cagcctctgt tactattact ggtatatgta cattttctcc
    63421 ttttgtattt ggctttacta taatatctat tccaggttta tcagttttag gaattatagt
    63481 tacattttca gttgaatgtc tctctactcc ttgcccattt ttacgtatat tgtatgctcc
    63541 taatggagtt ccacgaagtt cagcaacttt ttctaaaaga tttaaatcta ttttgttcat
    63601 ttaatttgcc ttcctttcta attaattcat gtctttcatt aattcacaac ttgaattaac
    63661 ttgacacatg atttcaggta atatagcctc ttttgttcca tggcttttta ctgaaccatc
    63721 ttgtagaaca attatttcat cagctaactc taatattctt tcttggtgag aaattatgat
    63781 tatagtctga ttagactctt catgtatttt cttaaaactt tcattgagtt ttccaaagct
    63841 ccaaaggtct atccctgctt caggttcatc aaatatagaa acctttaaat ctctagcaaa
    63901 aagagttgct atctcaattc ttttcatttc ccctccagaa agagagttat caacttcacg
    63961 atttaaatag tcttttgaac acaatccaac atctgtaagg tattggcaac atacatcagt
    64021 agacaatggt tttccatgag caagtgtaag taaattttca actgtcatac cttttattct
    64081 tggtggttgt tgaaatgcgt atcctattcc tttttttgct ctttctgtaa tactaagatt
    64141 tgttatatct tctccatcta aaattatctg accactcgta gctttttcaa ttcccataat
    64201 aagcttagca attgtagatt ttcctccacc atttggacct gtgataacaa taagttttcc
    64261 cctctcaaat gaaaggctaa catcatttat tattcctagt tcctcattgt tagactcaac
    64321 attaaaggaa agatttttta tttcaagcat aatacccctc ttttctataa aatattacat
    64381 taatatccat tcttttatta tatcagtaat ttttatatat cagcaactct aaggagataa
    64441 aatgtatatt aaataataaa acaaagttat tgaaaagtaa aaaagatgag ttttatgtaa
    64501 actcatctca gaaatttagt atatcaactt atatgtattt aaaatttaac cttctatata
    64561 ctctaatatt attttttgat tatcttttaa cataatttct tcttttttag attctattcc
    64621 attctttttt atctttacct cagctacaaa ggcatcatta ccttcaacca tttctaatag
    64681 ttcatacgct tttttacgac ctattttagt tgctatatct tttagtactg ccattttctt
    64741 aaacatttta tcacctctac tcaaaattta cacttaattt ttaattatat aattctaatc
    64801 ctagactagt ttataataat tattgtctct aattatatca gatattgagt aaatttaata
    64861 ctttgtaaaa ttatttatcc tctctgacca aataatcatt tccatcttgg tctttaaaag
    64921 aaaacatcct tccatatggc atctccatta attccccaac ctcaacctcg ttatttgcca
    64981 tttgttcata agttccatta atatctcttg tacttaaaat tattgatgga tgagatacat
    65041 ttatctcttt gttttgcttc atcattagat ttttatcata caacacaaat gttgtaaatt
    65101 catttttact tggtgctact tccacccatt tcatatttgg acccatttcc ttttcataag
    65161 ttactacaaa gttcaatttt tctgtccaaa ataactttgc atcctcttga ttatttacat
    65221 agagagttat ttttcctatt ttatttatca taacaatacc cacctttatt attaaataaa
    65281 tacctaatat tttttatatt taataatata cccatatata ttattttcta tagatatata
    65341 tttctaatat ttatcgccaa attatgtaat tctgctcaat atataattta taatatccat
    65401 actattatag cctttattta tgtaatttaa tcaccttata tatcatactt ataattatga
    65461 taataactac ataaaaaatc acttctaaat agagttatcc atctaaaagt gatttcatat
    65521 attctatgca actttgtgtt ttagccactt tgttcctctt aatcttaaac aatataaagt
    65581 ccctctaaca agccaatcag tatacatacc tatccaaatt cctaacactc caaattctaa
    65641 tacaaccccc aatacgtaac ctgtaaaaat tctaaaaatc cacataccta ttactgcagt
    65701 catcattgta tatctagtat caccggctcc ctttagccct gctgataata caaaggatat
    65761 aggccatatt accatagcta aacaatcact tcgaattaat tgtgttgaga tgtcaattac
    65821 actagcattt tgagtataca tacttgaaat ccagggtgca attggtataa atatagctcc
    65881 tactataaat aaacaaattg ttgcaaattt agttaaatat aataaagtac tcttagctcc
    65941 tttaatatct ccacgtccta tatactgtcc caccaaggtt gtagcagaca aagctaaagc
    66001 attcccaatt acatttatta tggatgcaat tgacattcct attgcattgg atgcaattgc
    66061 tgatgttccc atagtaacta taaatacttg aacaatcaat ttacctgcat taaaaagtag
    66121 ttgttcaact ccagctggta ttcctatatt aaatatagac ttttgagttt caacatcaat
    66181 cttaaatgga aatattttac ccatagatat aaattcgttt cctttaaata aagctcttat
    66241 aattactata catccaatta ttctagctat agcaatagat atagctgcac ctgttatgcc
    66301 ataggatggt gtttgcaaat ttattcctag aggatttaaa tcaataccat atataagtat
    66361 atatcccaat gttacattta ctatattcat aaacatagtc acatacatag gtttctttac
    66421 atctccacac cctcttaaaa taccatttgc tatttgttgt gtcgcaataa atggatacgt
    66481 aaataatgta aactctatgt ataattttgc atttgatttt accaattctt ctgcggaacc
    66541 ataaaataaa ttaattacac cagttctaaa aacccacatc aatattgtta ttgtaaagga
    66601 taatattact ccagacacta gagcctgctt aatagtttca ttcacctttt cactatcttt
    66661 ttttcctatt tgttgagcta caacaacagt agctccaaca gatagtgcag caaatacaga
    66721 tataaatata ttgtttattg aatcaaccat tccaactgca gatacagctt cttccccaat
    66781 atgacctgcc atcattgtat taaatactcc taaaagcatg acaaacgtct gctctatcat
    66841 tataggaatt gctaacttta taacattttt ccttataaac atccctattc ctcttttccc
    66901 tctttatata aatttaattt ttaattagtt tatcgaactg taaattgaca atgcaaagtt
    66961 tagaattgta ttgttcgcat tataatatac tgctttcaaa taatataaat cttgtttaat
    67021 atcatttgaa cacagtatat ctttataatt atcttatgtt tattattttt tatggatacc
    67081 acatttaaaa tatttattaa tttaatataa atattttccg ttattattaa aagtagctat
    67141 atttcgttaa tattgtatca ctatcgtgta gcaataacaa taagtacatt ttatatattt
    67201 tttataatat tatttaatca tccaaacttt taccactttt tcaatatata aaatattaca
    67261 ctttagatgt aacaaaatcg catccattta aatattgtat tttatagact aattttagga
    67321 tgtgatactt tggttaattt aaatgcaaat aatctaaatg taaatatggt ttatcctatt
    67381 tcttccacag cacccatacg tttcagaaga tatactgttt catatttaga aaacatggaa
    67441 aatatttatt taactatagc aacatacttt gatacacttg gtttaggcac aatgaatatt
    67501 gacaaagttt atggtcaatg ggcttggttt actgataata tatatgattt aaatctattt
    67561 gtttttgtag gaaattatcc ttatcaaatt gctaaaaaca gatatgatac atttgtagat
    67621 attttgccag tagctattac ttctattgtc aatggagata gagtattttt aatttcaaat
    67681 ccttgtttgt taaattcaaa aattacagtt agatttatat ctagtcatcc tactcttaat
    67741 agaacagttg attatggcaa tattagagat tttatttttt aaaactgcaa catgatgtgc
    67801 tattaaaaaa taccctaaat ttaatgatat tattaaataa ctagaatatt tttaattggc
    67861 acatcatgcc tagctattat aaattcataa tattatttta cttaagataa gtactgtatt
    67921 ttatctattt gtatattttt atttacctag tttctcagtt ctatatccta tttctttatt
    67981 agctagctta taaccttctt gtatcatttc ttctctcgtt aatgcactcc ctaataaatt
    68041 gtcaatactc agttgctttc tatcactaaa atacttatcc aataatgatt cctctatatc
    68101 ttcctgatat gccaaatttc cttcatgcat tatatatttt acatcaaaac cttctttatt
    68161 taatactttt cccaccaaga tacttctatg acatcttata ggttcttgca tagctcctaa
    68221 taaaactatc ctataaccca tttgacaacc cttttttaat ctttctattc cgtttaaaaa
    68281 aatatcttct tttgctactt tctcaaaatc tgcataacct tcttgcgtat atacatcttt
    68341 attagttctt ttagctccaa attcttttcc catgtatata tataaaaatc cggaatttct
    68401 aagagattcg ttaaatgcct ctttattgta ttgaatatta tatttagaat atggagtttc
    68461 tctaatgtca actacacaat ttatgtcata tttttttatc atattaataa gcttatcata
    68521 tggataattt gaatgtccta ttgcgaatat ttccatataa acaccctcct attctttgaa
    68581 attagtatct atatatgtag atacccgatt tacttaaaat taaataaagt attactttaa
    68641 atacccaata tctttttttc ttgatattgt atattttttt actttatatc cttaaaaaaa
    68701 tatacaactt tatatataaa acatcaatat ttatatatat tttgtatatt aaatacaatt
    68761 atttataaag tctttaataa aaatttataa atagagcatc tttagaaaac tattataata
    68821 aaaaaataag aggctgtcta aaaatataga taagcctttt ttcataatcg taattataaa
    68881 aatatacttg atttcatatg aaaaagagtg tctcataaac taaaatgttt actttgagac
    68941 accacctttt ttattcttat ttatactttg tagacatatt ataacatgcg tttcactggt
    69001 atctgaactt ctgtcaacca gtcttcttca ctctctttat tccatatacc atctatataa
    69061 gattctctag gatttccaac cactttatat ttattatcct ctatccattt aaatgcatct
    69121 gcgtaagttt ttcctaatgt tgaatatgga ccattgtgta atatacaaac tgcattttca
    69181 actgcatcta attctttaaa ttttaatata tccgtatctt cctttaaatc atttatagct
    69241 tgacacattt caacatccat atcagtctct ctatattcac catcatgata tatattaaaa
    69301 caataatcag gaactgcaca tgtacaccct gttttcatca tttcttcagc cattacattt
    69361 ggaaatagat taaaaagttc atcatacccc tttaacactt ttctcataga agcaacttta
    69421 acttttggta aagacttaat aattacatca ttcatattga cttctccttt caaattcata
    69481 aggtaattac gtagtttaat tattttatat tcttcacttt taattacatc caacatttct
    69541 ttttctttat tcattaaaat attttcaact tcttcaggat tttctacagc tttttttatc
    69601 tcagctaatg ataaacccat ttgttttaaa gttattatct gatgtaattt aggtaattgc
    69661 tctgttgtat aatacctata ttttgtaaat tcatctacat attctggttt taacaaccct
    69721 atatcttcat aataccttaa tgtctttgta gttattttat ttattttaga aaacattcct
    69781 atagaaaaca tctcatcacc tgcgcattag atttgattaa tttaagttta aactttcccc
    69841 ttaggttaaa gtcaatacaa aataaattat aattgtatta attcttcaat tctatctcca
    69901 ctcaatacca aaatatcccc tgtttttata atggttgaac ctttaggtat taaaacctgt
    69961 tcctttcttt ttatcataac tattaatata tcgtctggta tattagaatc tattatactc
    70021 ttattagccc atttattacc ctcatcaaca tttacttcga taagtttaga gctaatttct
    70081 ccatcataat cattaaatgt ttttaataca ggtgtattat catcaactaa atccaacttt
    70141 ctggctacag ttggtatcaa tgaaccttgt attcctactg aaagcaacgc tataaaaaat
    70201 attatatgga atatgtcatt ctctatggct actccttgag taacagcata aattgcaaaa
    70261 actactgaag ccgcacctct aagacctacc cacgatatga ataatttttc tttatttgag
    70321 aatttaaatt ttgctagaac tataaatgtt gctaatggtc ttgcaataac tatcatgaat
    70381 atagatatgg ccattgctat accaaataca tttggtaact tagaagggaa agataacaat
    70441 cctaacataa agaataacat tatttgcata atccatgaaa ttccatcaaa gaaatgaacc
    70501 aaactttttt taagaggtat cctactattt cctataataa tacctgaaat gtaaacactt
    70561 aaatatccat ttcctccaag atactcgcta aatgcataag aaagtattgc aatagctgtt
    70621 ataaatatag tataaaatcc ttctatctcg aagtttgaat gtcttaaaat ataaacagat
    70681 aattttgcta gtataaatcc tatagctaac ccaaaagcta tttgttttat taccattggt
    70741 gcaataagtt ctaccccaga attattcatc aatgtcaaaa gaattagtgt cagcatatac
    70801 gctattgggt cattacttcc actttcaact tctaataatg atgcaagtga accctttaag
    70861 tttagttttt gagaacgcaa cacagcaaac acagatgcag catctgttga agctgcaatt
    70921 gccccaatta ataaaccttc aagtaaacta gttcctatta ccatgtggca aaacatacct
    70981 gtaaccccag ccgtaattat tacacccagt gaagacatta atatagaagg tatagcaaca
    71041 ggtttagcca tattccagtt tgttccaaac cctccaaaaa acattataaa tattagtcca
    71101 atagaacata attgttttgt cagttcatag ttatcaaaat agattcctac catcccatca
    71161 gacccaaata acatccctag taagataaaa atcaataata ttggtactcc aaatttatac
    71221 aataccttgc tagaagttat acaaatcaat agtactaacc cacttataat cattaattct
    71281 gtcatagcat caactccatt tcatataaat tttgtagatt aatttacatc tacaatttta
    71341 ttacttattc aaatataaca tgacataaat tttataagtt atggtacata aagttcaaca
    71401 aaaatttcac aatacattaa aatgtgagtg ttatacttaa atttatatat ttgttttaat
    71461 tatattcatt taatatttat aatttgaatt tttttttatt aacatttcat ttttcagttg
    71521 attgtttaat atatttcatt ttttatagta attttatata taactacgaa atataaagta
    71581 attagataag taacaagaaa ctaacatgta atgttagcta ctctagatat gaaatcttaa
    71641 aacttttaaa tattgaaata tttctttata tatattattg tatatttctt ataaattatt
    71701 gtcaatttat tttttcttaa aaataaaata attgcataat ttatttcaaa ttatgcaatt
    71761 tataaaattt attcccaaaa ctcttttact gcttcgatta tctcactata aggcaataaa
    71821 gtcgcttcga ttattgattt atttgtcttt tctaaataat acttaatcat ataatatcca
    71881 caagcatatc ctgcacaata aggcaaccct actggaaaat atccttgcat tttagctata
    71941 tcatcaccat aaagataaga tgttatattt tgaaatccag tttcttttaa agcacttttt
    72001 attattggct ttatataagt atttaatgtt tcgatatctg ttctactgac ccaaggtcct
    72061 aacatttcct ctccaaacat ccatgttgca aaattttctg caagaccttc atttatcatc
    72121 atttcttcta atgttatatt attattccac tctataaact gaaatctaat attgtgatta
    72181 cattcatgtg ctattaatac tggtaatcta ttgatagtat attcattagg aaccaatgat
    72241 agaaatatat atccaggaat cccaccatca ccccagtatc catcacttaa tattgtataa
    72301 ggactatttg gattcgccaa taatattgaa tatttatagt ccttaatgtt taaatcatac
    72361 ccttctttta taaaagcatt tatagagttt tctatggttt ctttgcaagt gccccaaatt
    72421 ttatcagcag ataacacatt tatattcttt ttttgctttt catcaatatc cttaggcgat
    72481 aaaaccccta acatttcact tgctataatt acatcatatc cacctttctg tctagcaact
    72541 attggaacat tcatacactt ccacttaaat tcaaaaggct tcattaattc atatctgtat
    72601 atatcttctt ttttgtttat tggtgcatcc attatcttct tgtatatttt atctgagcga
    72661 atttctataa tattcatatt taccatctcc tttaagacaa agtatataca attacgtagc
    72721 gtcaatgtca atatacattt tttataatgt caccttaatc tttttattat attttatcct
    72781 gtaaaccttc cgtacatata acattttttt aaattaataa atttgtataa tataataata
    72841 aaaaattata tacttcaagg tttccctatg atacaattta ctaaatcata atttagatta
    72901 tcaggtgcaa ctataaatta ttctatatca aggaggatat attggtcatg ctaactccat
    72961 atttaatatt taatggtact tgtgaaaaag catttaattt ttatgctgag gctttcggag
    73021 gaggaaaaac tatatttgcg cgattagaca gcaatccaaa caatcctatt atgcacgcaa
    73081 gtgttacttt cacaaaatac gaaggttgta taatgggtgc ggatacagac aagcctgttg
    73141 taatttctgg catggcgatt tgtgttgttc taccatctcg agaagcgata gaagaaatat
    73201 ctgtaaaact tgccgaaggt ggtacacttg tacaagaatt tttaccacac ccaccaccac
    73261 atcaaaatga tggcgctgct gaagtacttg ataggtatgg gtatacttgg tatttaagta
    73321 catagttaaa ataaaaaaac tacatctaat aatcataata tagaacagat aaatttcaat
    73381 ttaatagtgt agtaaaaaag tcgtgtccta agactgtcac gacttttatt tgtataaaaa
    73441 tttaagtaaa tatttttgcg aataagtggg aagtataact ttaaattaat ttcatatgta
    73501 gtattggaaa tgggttccct tgtccatcta tttcagacct atcaaacact ttaaatccta
    73561 agtgaatata aaatcctaca gcttttttat tctgctcatt tacatcaaca tattttacat
    73621 tgtatttatc tatagcatat tttattaatt ttttaccaat accatttcct ctatatttat
    73681 cttctataaa gagcatctca attttatctt tatctattcc tataaagccc tttattatat
    73741 cattatcttt tatacaaact atattttcta cttctttaag tccaatctca actaatggta
    73801 tcaaagattc aatatctttt tctgttaaaa aatcatgcgt tgctcttact gatgattccc
    73861 agacttgcaa catttcgtca tattctgttg aatttatttg tttcatttca agaattattc
    73921 cagatttcat aaaaatttcc tccctatatc acttttaatt gcataacact tttttataca
    73981 aaacttagaa aggactacga aggttaaata tcatagtcct cattaagttt aaatattatc
    74041 tattatatat tatactataa tctagcaaat tcactacaat aattcacatc agcttatact
    74101 aaaggtgctt ctatttgagt agtaaaaagg aatttatgac aatgaccatc attaacagta
    74161 gtttctccac atattaagtg aatgtgttta tcagttccag gtattctaat tgctggccct
    74221 gttgtaacac atatcttatg gaaatggtca aggaaatcta cattatcatt tattttatga
    74281 acatgatttg tacctccatt tattggtata acttcaccag taacccctgc tgcacggtgg
    74341 ttatgtctat cctcacattc ttctgctaac ttaacacttt ctgaatattc atgaacatgt
    74401 gtcatttcct cataatcatt atagcacttg ttgcacttat tgtatttata atcatcatac
    74461 acataatctc tttcacattt ataattttga taactcattt ttatatctct ccctatatta
    74521 tattaagaaa ttcttgtaaa gaatctctaa tgtataatat gaattaaagt caaaaaagtt
    74581 catattttgt aaaattatgt attaatttaa ttatttttcc cagtatttag ggcgtattag
    74641 tgaagctggt aacttcgtac tagaatctcc ttttgcagta tttacttgta attgtgttaa
    74701 aaatatacta ttttcaagat tagcacctct aatatcacaa tctcttaagt ctgctcctat
    74761 taaatttgcc ccactcaaat ctgtatttct taaatttgct gctattagaa atctacctct
    74821 taaatctgct cctattagat ttatttttct aaggtctgct cctattaaat ctatattttt
    74881 acttaatttt ttcatgtttt taagagtaga agtcttgata aatgatttaa cctttcccat
    74941 catagactca ctcgcttgtg ataataataa attaaccttt gttctatgtg atatgatatc
    75001 caaattaatt atctgttctg gacccatatt agttatcttt tcagtttctt caattattaa
    75061 atcaattttt gatttgattg tatctgatat atttaataca gatgcttctt taagatacca
    75121 taacatttca tgtaattgtc tcataattaa aaacacttca gacatttgat ttgttagttc
    75181 tggtgattgc atccagtcta tccccttata tgttacttgt gctacttttt gacctgaacc
    75241 aaaacaatca tatgcagtac accctttaaa acctcgctta ataagactat tatgtacaga
    75301 acatttaaaa tctggttgta aattaataca gggttttcct gattccttat tgataggaaa
    75361 tccatctgaa gcagaaaaat aaagagctac acagcaaagt ccaaagcact tcttacagtc
    75421 aatctttagc tcctcaaata acttattatc atatatattt ttatgtatat ctatcatatt
    75481 ttttctcctc ttaaacttta tttttaatat tatattatct ataactaaat gataatcaag
    75541 tcccttattt aacagttctt attcttaatt ataatttaag gtattattta ttccaatagc
    75601 atacataagt ttctttatac ttgtaacaat acctttatac taagacttat tttaaatgta
    75661 gcactgtaat aataaattgt ttatatactc ataatgtatt tgataaattg taaatcttta
    75721 tagaagttga aatttttaat gattttagaa tcaagatata ataataaata caatttataa
    75781 aatcagaaat atataaatta actatacaaa cctaaataac atagcattta aatttacaat
    75841 ttcagtataa atagtacaaa gtatattagt ttaaataaga ttggcttatt tgtagaggag
    75901 agaatatttt ggtgttcaat aaaatttata tttaataaaa ccataagaaa atataaagat
    75961 aaataaacaa acttttatta cttaatagat tcttatggtt ttatactgta ctgaaaaaca
    76021 ataaacacta cagcttattt ataatattac gcttttttaa caacagaaga ctttagcttc
    76081 atagctccaa aaccatctat cttacattct atatcatgtc catctgatga gtcatggatt
    76141 aaacggatat ttttcacttt tgttccaatc tttatagatg atgaacttcc ttttacttta
    76201 aggtctctaa ttactgtaac agaatctcca tcatttaata catttccatt tacatctttg
    76261 ataatatttg aatcttcttc agctcccaat cctaatgccc actcatgaga gcattctgga
    76321 caaactaaaa gagttccatc ttcataagta tattctgaat tacatttcgg gcaatttggt
    76381 aaattttcca tctttatatg tcctccattt gttattttta gatttcttat tatataaaat
    76441 ttcttttgag cctttatgat atcatattat acttatattt acaaactact aatttactta
    76501 atgtttaaat tctattcgta ttattattaa acttaattta gctgtaatct ctttcttata
    76561 tttattatag tttatattat tacaatttta taactctatc tgcctgctcc gataaatcta
    76621 aatcatgagt tacaaatacg atagttttac cattcttatt tagactttta agtatatcaa
    76681 atactatgtc tctatttttt ttatctaaat tacctgtagg ttcatctgca aatattactt
    76741 cacattcttt taatattact cttgctaatg ctaccctttg ttgttctcct ccactcaatt
    76801 cgtatatctt ttttttattg tattttctaa gacctacaga ctcaagtgcg taatttattt
    76861 tttcattatg attgatattt ttttgatact ttaaagcaat tttcaagtta ttttcaacat
    76921 tttcattctc aattaaagca taattttgaa atagatagcc ataaaaatcc ctttgtaaaa
    76981 ttcttatctg tttactattt ggatttttta tattatttat tataatatca ccagaattag
    77041 gtttttctaa taatcccatt atattaagta aagttgtctt acctgaacca ctatttcctg
    77101 ttatcgctac aaactcgccc ttagaaattt ctaggttaaa tttgtctatt atagatttat
    77161 ctttaaattt tttagatata tttattaatg aaatcatctt tttaatgttc tccttttata
    77221 attttattaa atgaactatt tgagataatc ttgtctaata caatagatac aattacttct
    77281 ataactaata ttagaagtcc aaataagata atattattac ttaaatctac tcttgttgat
    77341 ataatgccta ttggaataat gtttgttaat attaatgaga ctattaacaa catacttcta
    77401 gctgtagttg agtaaccaaa tattttttta atatataact tatatttatt tctttcatag
    77461 tagctagcta ctatattgta ggtaatcatt aagtttgata ttgctattat tattatagta
    77521 aaaatttcac tattcaaata tttttctagt ttatttattt ctaaaccata ctcattataa
    77581 acagcatgta aactttggat atgcgcttct acaccttgag cttcaataat gctacttata
    77641 tctgcaaggg catctaattt cttagaatta aaatatacac atctagatat ataagaaaga
    77701 taaaaagaat catcaatatt atctatgtca actattgcta ttgggtcatc aatgagattc
    77761 ctattgtcat ccataacaag ggagttataa gtaaaatagc tttgattatt atctacatat
    77821 attatattaa catttaaatc ggacttcttt gttttattta actctctatt taactcttta
    77881 ttgtacatat tttctacttc tattttttca aaataaaata attctctaaa ctctttttta
    77941 atctcatttt catgtacttg taacttttta ggaactaata aatttatagt cttatcgtca
    78001 taatcgatta gattaaatat ttctttgcca tttgagtaaa tagggttaac tttaagatag
    78061 tttttattta tttttatatt tttaccatat tgacttactt ctgggttttt accctttgaa
    78121 tttatttcat acatgtaact tccatcttca agtttttcaa aattagttga atctattaag
    78181 aaagcatctt tttcttctac caaattttta tagaaacctt taatcttggc atttttaatt
    78241 acttcttcct ttcctaaaga ttgttcgcct gtatctttaa gagtaagatt ataaacattt
    78301 tttgctttat cccactcaga tagatttcct aactgagttt gtagcatatt ataatttaaa
    78361 atacagttat ttatggataa tataagaaat gatacaaata caattttcaa tgtgaaatgc
    78421 attatattta caaaaccata agattttttt ccatttagag atagcacata tttagaactt
    78481 ctactattaa aaccaactat taatatagat atcaaaatat ttatcaaaat acatataatc
    78541 gaaaacatag caaagtataa gcatgctcta acacctatat ttaattttaa aatatagatt
    78601 atatatatta ataatgctgt gacagatgat aaaatcataa ttctaagtat attttttata
    78661 actctagcaa ttatatctag cttagagtat ccatttaatc ttaaaataga agcctctcta
    78721 ctcacactaa ttgaataatg tattattgta gccaagaaac aaaggataat tagtattaaa
    78781 tctctaatta ttgaaggatt taagtataaa tttgagttaa catatctatc atgtaatctt
    78841 gctacaaaaa tacttctgtc tacatttagt tctcttaata ttttatttat tgtatcttca
    78901 ttttgagttg aaatatataa gattcctgat tctccaactt cacttatttt accaaaatcc
    78961 ctaattaaaa ttgatatgtc tttactcata gttgagaatt tacctacttg attactatta
    79021 ttagtgttta tattactaat aaattcattt gaattagtat taggaaattt tcctgatttt
    79081 aactttatat tgttattcaa acttgtatca gtcgtatata tagataattt ttcattatta
    79141 ttaaaaacat actttgatat agccacatta ttttcatctg caatatcttt aatccactta
    79201 ctataatttt tatttaactt tttataatct ttaaacatta cagatatact tgttgtatcg
    79261 ttatataaaa tattattaat ttcattatct ttaactatat ttagacctaa taaagatact
    79321 attaatagtt caattgtaaa taatacatat attatctttt tcaattatag ctccctccta
    79381 attgttttta ttctaaaagc aaaatacatt ttactttagt taaagtataa tgctttgtgc
    79441 cttttctaaa caactactat attgtcacat tctaaatggc aagtgtctat ttcgtcacaa
    79501 agataaaaat agccttaaag cagttaattt tttataatca actgttttaa ggctattttt
    79561 tatttttagc aaacaatatt ttaatagtgg tataaaatta gtataattca ttaatataga
    79621 ttctagtctt ttcagtaagc aactaaaata atatcttatt taaaacgaaa tttaatttaa
    79681 gtccaatata aactttactt taccattaaa tcgtgctagt acataggtat gcttcttttt
    79741 tattccatat aatggatatc ttatgaatat ctatagaatc aagataataa ggttgtccaa
    79801 tttggaattt agaatatgta tttttaaatt ttttatttac atataataaa aaattatttt
    79861 ctttattaat cacacaaata cactggtcaa tattatctaa aatattctgg tattgttgaa
    79921 tctgttgatt aagtttatta ttttttttac gttgtaaaaa cattgatata atttgagaaa
    79981 tcaatgataa tgtacttatt tcctcttgtg accatagacg tagtcctgtg cattcatcaa
    80041 atccaacaaa tccactgaaa actctatctt ctttatatgc acattgaagt gtagagtgga
    80101 taccttgact agaaaacaat tcttctagtt taggacttaa tgtatggata tctcgacaat
    80161 aaaaaactaa ttcatcctca aaaagctttt cataatcctc atagtcttga taattgctgt
    80221 tttgcaaata agccatttga gaagagattc cttcattaca ccattcataa gtattagaag
    80281 tatatctacc atcttctgta ttttcaaaaa tataaacacg acttacatca aactgtttcc
    80341 caacaacctc aagtatcata ttaatcgcct ggtctatatc atcagtctga taaagcatac
    80401 ggaatatata acgtgtaaga ttatcaggat attcagcgta ttgtttttct gaatcaataa
    80461 ctgtaccaag agaagaacaa tcaaattctt ctaattcttt aaaataatct tggttgtaga
    80521 ttacataatt attttttccc atattttttg cttgatacag ggctttatca gctcttgcat
    80581 atatttcctt gaatgtagta ccatcctttg gatatatagc tattcctatg ctacaagtta
    80641 cttttagaaa acttttttct ttctgaaata gatgacggaa catatacaat agttcttctg
    80701 ctttcttttc tgcatcttta actgaggaaa tattcttcat aaaaattgta aactcatctc
    80761 cacctattct tccaacaaca tcactgtcac gcattatttt tttcatacct gatgccatct
    80821 cagtaagtac tatatctcca atcatatgcc cttctgtatc attaatctgt ttaaaattat
    80881 ctgtatcaat cataaacagt gcacccataa catttaaatt tttttcaaaa tatttcttaa
    80941 tctgcctttc agtctcagca cgattataaa ttcctgttaa tgcatctttc tctgatatat
    81001 gctgtaattt ctcaatctgt tttctttcct ttgttatgtc aatacctata ctataaaaag
    81061 atggtattcc atcccaactg tcttccccac tgatataaca caatgtaaca gtccatatac
    81121 gttcttccct tgaacgtgta tatatttttg cttcaaatac aacattatcc ccagactcct
    81181 tcaaatcttg tgccagtttc ttactacgtt tataatcttc agaaaataaa tatccacatt
    81241 gattattaag ttcctctgca aactgttcct ttgtatattc aatcatattc aaaaatatat
    81301 cattacacca aagtatagta agataatctc ttgcatctaa tctaaccatt cctgctggaa
    81361 tagttttcaa aattgattct ctttcctgat ctttttttgc taatttatat tcagcactat
    81421 acatatcata agataattca atacgaactc ttcgcccttg ccaattcaac atacggtctt
    81481 taattataaa tgttcgtttc agttttttat tataaaattc ccattcatat atgtcatctt
    81541 tttttaaata cgaatttgta caaaacggac atggcgaagt tctaccttga attacctcat
    81601 aacattttct tccaataagt tcatttgctg atgcctgtaa agtattgcat gagtgcttat
    81661 ttaagtatag taattcatat gtatccatat cgctaatata aacattccca gcatactctg
    81721 acatcatcca tttaaaattc tctgtactct ctttttccat atcagatagt tcttcttgct
    81781 ttatttttaa ctcattaatt tttgaataca atatatagac cattgatttc tcattatctt
    81841 gtgattcaat taatatacca gtcattatta cccaaacagg gtctccatta tttgctgaaa
    81901 tgcaaatttg atattctata ctcttttcgc catgatgata agcctctaaa aaatgatttt
    81961 tcatagattc aaaatgataa agattctgtt cataataatc ttttaaacta gaaaatttaa
    82021 ctaaaaattc ttcttctgta tatcctaata attgatagaa tgatgtattt ccccatatta
    82081 ttgtaaatga atcatctaaa aaatgtttac tgaccccaat actcatagat tttagaatat
    82141 cctctgatat aacttcattc tttgttgctt gttctttttt acacattcga tgtaacctaa
    82201 tgtcttcttt cattgtttta attatcctcc tatctttaga ctcactttta attcactctg
    82261 ctttttaata taatgataaa agtgaatctt caacgtgtat aaattgattt catttacaat
    82321 tatttttgtt tgaaattgaa ttttcacaca cacttgctaa gattctccct ctaaaacttt
    82381 taatttagta atttttttga tgccctattc accatttaat atcttaatta tcgattcttg
    82441 ttcacttaaa tctgtattta acttttcccc taaaaacaca ttattttctc atatttacta
    82501 aaaatcgcct tcttttaatg aaattatatc ataacttaag ttttaaatca tttttttcca
    82561 gatagaaaaa ttaagataaa attactgaaa ttatatgtaa tataatagaa atgtaaactg
    82621 ttttaaattt gaataatatt aaaaaggctg tatcatagta attataagat actatgatac
    82681 agccctatgt taaatttttc ttacattttt aatgatttca cgaatcttgt tagcattttt
    82741 agcaatatct tcaacagaac ctttagttaa taaaccacca aatccacata catcaactcc
    82801 attttctaac catatatgta ggttttcaat attaagccct ccacttgcta aaactggcat
    82861 atcaggtatt ggtgtcttaa atacctttac tagtttaggt ccatagaaat ctgatattgg
    82921 gaaagctttt ataaaagttg ctcctaaact tagtgcgtct actgcctcag tcaatgatgt
    82981 acatcctgga gcataaggaa tctgatatct attgcaaatc ttcgctacac cttcattata
    83041 atttggtgca ataataaatt gggctccatg taatatagca tgacgagctg tttcactatc
    83101 caaaactgtt cctgctccca cacaaagtat ttcaccatac tttttattaa gcccttgaat
    83161 tatttctcca gcattattta gggtataact catttctata actgttatac caccttttat
    83221 acatccttca gcaatttcac atgcacggtt aagattttct tctcttacaa ttgcaagagc
    83281 cccacattct gacattcttt tggttatatt catctttttc atattatcac ctctatactc
    83341 atcaaaccac tttacttatt cattaatttt agtcatgttt tataatatat atattaatta
    83401 tataccagtg taatttccct atttatatta tctattctca ctacttttat taagtattgt
    83461 cctataattt tcaactactc gtttaatttc ttcaagtact tccccagttg gttcagttac
    83521 aggaagtcgt gcagttccaa cattaattcc attcaagaca atagttttct tcataacaga
    83581 tggaattgtt ccaagtttca gtatacgtcg aagttcttct atactacttt gagatttttg
    83641 agcttcttcc aaatcccctt tcataaagtt ttcatagata gagataccaa tctctgtgag
    83701 gaagtttgtt gttgctgcaa cagctccttg gctaccagct tttagactat ccagaataag
    83761 tgaatctgag cctgaaaaca cactaaaatt ctcattcttc gttgcttcaa tataagcttt
    83821 catgttgtca agtttaccac tactatcctt aattccaaca atattcttta tctttgataa
    83881 ttcacgtact gactctggtt caatattaat tccagtctta cctggcatat tatacattat
    83941 aataggtaaa ttaactgaat tagcaatagt tttgtaatgt aagattaatt cctgttgtgt
    84001 tggtgtaaca aagtatggtg taataataga taatgcactt gctccaatcg cttccattct
    84061 cttagataaa tctacaactt cacgagttga attaccccct gttccaacaa aaacaggtac
    84121 acgattattt gtatgattaa taacaatctt tgcaaattca actttttcat catctgttaa
    84181 tacatgacat tcaccattag tgcccaaaat aaataatcca taaattccct tttcaatcaa
    84241 ataatcaatt aattgacatg ttgcttgtga attaatattt tgattttcat caaatggtgt
    84301 tatcattgca catataatcc ctttatattt cataaaatta tattccctct ctaatagact
    84361 ttccaagact tcctgctgga tgccacttca aatactcctg tgtattaaga cctttagcat
    84421 attgtaatac aacacttaat gattgtaata ttattgtttc agctaaaatt gaagcacgag
    84481 gagctttatt gagacaatct ccttcctgct taacacctgc aaacaggaat atatcagaaa
    84541 tattttttaa aaatgaactc tcattaccac ttacaccaat tatctttgct ccatttactt
    84601 ttagagtctt aagagttgct tttaactctt gagtttcacc actatttgat attgcaataa
    84661 caacatctcc ttcaactact tgaccacttg acccatgtac tgcttctgta ccatgcaata
    84721 tatatgctga cgttccagta gatgaaagca atgatgaaat atatcccgat acatgtcctg
    84781 gtttgccaat accagtcaca tgtacacgtc cgtgattttt ttcagcttca agaattaatt
    84841 cgcatgcttt atttatagat gtctcatcta ttgaggcaat aaattctgac aattcattag
    84901 atatattatc taaaaattca gataatgtat tttccataag atgtatcctc cttgaaatca
    84961 tagtaactat gactatactt ttatataatt tagtctaaat aggttttata aattgtaaaa
    85021 tattatgtaa tatcgaacca actacgttgt aatcaatatt agggaaagtt gctccttcta
    85081 taccaagagt cccataaact ggatatagta taactggtaa aaatgcaagt aataacccca
    85141 caacaaatga cccagcaata gcccctctcc atcctcctga agtattgcca aatattgcag
    85201 ctgtacctcc tgagaagaaa catatgtgag cagctggaat aattactaca ggaaatatac
    85261 taggaaatga tgccataata gcaattgcta atagaccagc agcatatgct gatataaacc
    85321 caataataac tgcatttggt gcatatggaa atacggttgg aacatctagc gcaggacgtg
    85381 aacctggaat atacttttct gaaatgatta caaatgctgc agttatttca gctaagaaca
    85441 tacgaactcc tgacatcaat attgacatac ctgccacaaa tgtaaatgcc tctataagcg
    85501 gaaaaaccaa ccaatgtgtt gaaccagcaa tttcttgagt aaatgcttga ccagctttta
    85561 atgttgcaat ataaaataag attaacataa ctatggatag acccattaag aagtctctga
    85621 atattgataa ccacttagga aattctatag tctctgttgt atcatcttta tgttttgaaa
    85681 ataaacgccc aatataacct gataaaccat aaccaatcat gttaaagtga ccaatagctt
    85741 gttcgtcgcc acctgttaat tcacgcataa atggttgaca gaattgaggt agtgcagcag
    85801 acataaaccc taagatagtt ccacctatta aaatagtgat tgtattatca aatccatgtg
    85861 ctttcataat taaaactaat acacaagaaa agaacaaact atgacctgtt gtaaagaaaa
    85921 tattcttaaa ctttgtaata cgtgcaaata ctaaatttaa tatgaatcca agaattaatg
    85981 tacatgaaac tgcaaaacca tatgtacctt gtgcaagtgc tgtagctgct tctggtgaag
    86041 ctataacacc agtaattcca aagccatgtt ggaacagttt attgaaattt tgaagtgctc
    86101 ctgtcatagc agaggcacca ataccaaata tcaaaaaacc gataagtgtt tttgaagagc
    86161 ctgtaaatac ttcaacagct gatttctttt gaagaatcaa tcctatacat gcaactacgc
    86221 caagcaaaac agcaggtgta ctcagcaaac taataataaa ctccataaat attcctcctt
    86281 atcatcttaa atttatccct cttttgaagc aaggaatttt tctagtgctg tctttatttc
    86341 attacggtca acaatattgt gaatcccaat tatatcaaac ttcaaatttt tattttttaa
    86401 ttcttcagca acatcaatta atgtttctac agcatctcca ttgaatccat ttagtgaatc
    86461 caatgaacca tgttctactt caattggaaa gttattttcc ttaataattt gttgagtctt
    86521 tatttttaac attaaacttg agccaactcc tgctctacat gcgattaaaa ttttatacat
    86581 aattaaatcc tcctttataa ttcgtgtgtt tttataaaat caataatttc tttagcttct
    86641 ttagcactat ctaaaacctt aaaaaactca tcttcttcca atagttcaac tagctcagac
    86701 atagcacgta aatggctatt attgtctatt gcacttagac aaaatacata ttttacaggg
    86761 tcgttttcgt tattcccaaa ctcaatagga ctatctaaag tagcaatgcc tattgcaatc
    86821 tcttttgacc cagcttctgg tctagcatgt ggaagtgcaa catgttttgt aattactatg
    86881 tatggtccag atgcttttgc tgagttaatc atagcatcta catacccttc agttactttg
    86941 ttattttcaa ctaatacaga agctgactgt ctaatagctt cctcccaatt cttagctttt
    87001 acctttattt ttactagtgt ttcattagta atctcactta gcataggccc ctctccttcc
    87061 ttagatgtaa aattctctat ctgtgtaaaa taagctaata gctcacttga aagaatactt
    87121 tcagaggtta catttgcata tttttttatt atatccataa cctcatctat tttaggttgt
    87181 cttaaaaaaa tatcacctaa ttgaatatac acttcacgtg taatcttata tttttctttt
    87241 gtggtcataa cagggcttac tttaattact ggtacatctg tttttaaacc ctctgcgtta
    87301 taattagtag taaatacaat atctacaggt tcacttatat tttctaatcc aactgattcc
    87361 gacattggta taaagtgtaa gtcaggaaat aagtttgtaa gttctgcatg taaaatagct
    87421 gaactaccaa cgccatttga acaaactatt aatgctattc tttttctaaa accatcaaat
    87481 tcttttttat ttgaaaaaag tgttgcaaag tgcattgtaa gatatgctaa ctcttcttcc
    87541 tgaatttctt ctccaaataa tccgcaaaac tctttcattg cattacttac aattctataa
    87601 actaatttat attcttcttt tactttttca caaatcggat tataaatagg taatttaaat
    87661 aaaagtctat agtaggcagg tctaaaatga gaatataatt gtttaaatat tttttcttgg
    87721 cttatatagt aaactccgct taaatatcca aactttgtca tcattttatt tacaattttt
    87781 gaaattacat ccttatcttc tgtatcttct tcataatttc ctactgatat acctaaaatc
    87841 caagcactaa tatacattat attgtgaggc tttatcttat cttcactccc atatacttct
    87901 aataattcct tagcaaattt atactccttc attgaactca taactgaaat attaggaata
    87961 tctacatttt cctgagtaac tattctagtt gaatacatcc ttgcctttag aaagataaat
    88021 atatatataa attctactaa tctatcttca acaaaagtaa tttcatattt ttttattagc
    88081 tttaatataa tttttttagc ctcttcaaaa ctatctaaat tatattcttt aataaaaata
    88141 tcaaatactc ttgaactttt ctcattagac aaagtttcta taatattttt aataagcact
    88201 ctcctaattt ccatctcatt gccaactatg taatatccat ttatacgatt gttcttaact
    88261 ttaatgttct tcttttcaag ctctggtatc aaatccttga aatcaagatt tacagtagac
    88321 ctacttactt ttatagaatt tataaaatga ttaattgaaa tatcatccat gttaataaaa
    88381 agcattaaat acatatataa aagtctttct gtcttactaa aataataagt attcttagaa
    88441 tagttttttt ctaaaatttc tttaattgct ttttttgttt cttttctaac gataatatct
    88501 ttatcagctc ttaaacatat aagtggtaca ttttttactt taagcatgtc attgatttta
    88561 tttattctat aagtaatttg tctctttgat gaattagact cctcttgtaa tccattagtt
    88621 gtaatcaatg tgctatttaa taaaatctgg agaattgata caatttcttt gtccactacc
    88681 attaacccct actttcttat taagattagt cttcatatta tcattggatt ctttcatcac
    88741 ctccacaata cttattttat ttgagaattt tatcgttttc aatttcattt aagtataact
    88801 tttgttttag attgatacaa aaattaaact tctctaaaat agatactata atataactgt
    88861 agattttata aataaaaaaa gtttctttag acaaagaaac tcaagaaaaa ttgatttaaa
    88921 taataaaaat catattgatt ataaataaat tactacaatt aaaaagcaca ttaatttaaa
    88981 ataaaattga tgtgccttat ctataatata atatatttaa tctaattttt aacttggaat
    89041 ttaacatcct tttttatgaa atcaacttat gtacatatac aattcatact ctatttttat
    89101 ttcatttttc taagtgtttc ctctaatgaa atacacttcg catatctttc attccatata
    89161 aattcattgt agtatttata tgattgttct gctgacataa aaaaattgtc aacagttgta
    89221 tttgaataag ctggaactat tatattaaat ccatgttcaa atccacattt tatagtggca
    89281 tcaatacaat aatctgtttg gagaccagca ataataatat ctttttcacc attatttgtt
    89341 aggtattcta atagaccagt ttctttaaaa gcactattta cttttttatc aaatattttt
    89401 tctccattac atggtttaaa tttttcgtat atttcaaagc catttttacc tttagtcaat
    89461 tcattttcaa ctccatcatc atgacgtaca tatattactt ctatattatt ttttctagct
    89521 gtatcaatta aattttctac atttactaca aattcattaa atttatataa cctctcgttt
    89581 gttattaact tttgtgcatc aacaatcagt aaaaccatgt ttattcctcc ttggatgttc
    89641 ttctaataat atctttatat cttaccataa agatatatat tactctctaa tatttttata
    89701 taatacattt cctggattta taactattaa tgcaattgca aatattaaat ataacattgc
    89761 atagtaattt ataagctcta ttaaatctcc attaattatc cctattaaaa aattaaatag
    89821 ttgatgtatt acaataggta ttatcaaagt tttatttaga ttataaaaag ttgtcattat
    89881 aatactgatt gatataattg caatcataaa aaatataata tattttatta aatcaagtcc
    89941 tttgaatcct gttgtaaacc atattggtaa atgccacatc ccccaccaaa aacctactat
    90001 tatggatgct tttaaaggag aatgtctttt ctgaagatga ttttgaacaa atcctctcca
    90061 acctaattcc tcacctaatg atcctgcaaa taaatttttt aaaaataaat atataaatgc
    90121 tccccatgat gaaactgtaa agttaggcat tattccatga tttttagatg ctaatataaa
    90181 tataactact acagctatta ggacttgtat actaattatt atagatactg ttgaaaattt
    90241 aagtttattt ctaaatctat cttttacgtg tactaaaaat ttcttacctg gataaatttt
    90301 tttaaataat atcataaatg caaaagtgga tgaccacgct gatatacaca acgcaatgtc
    90361 agatatcact gttggaagtt ttaacattat agtcactact accaataaaa aaagtggtaa
    90421 aaaaattata tttgttagaa taataaaact ggctataggc ctttttaatg atttctctgt
    90481 tctcataagt aatcctcatt tcaaattaat atttaattgc tatataagtt ataactgctt
    90541 atatcatgag tttaaaccta tgagtaagtc ccaggtcaat gcttttatat tattttatag
    90601 gtgcataaat ctctaaaaat atacgctcaa tcccttcttc ataagtagta agcaatatat
    90661 taacatagac tattccaagt aattcacatt cattttctat tgctatttct cttaatctgt
    90721 cttccacttt attatcaata ttttctcctc cagttgacca tctgccatct tcaataatag
    90781 tataaataca attgggatga gatagaactt caccttctat gattttgttg tagtcatcta
    90841 cttcccttac aattataaat ttttcttcta ttataccttc ttcattaaaa tttattactc
    90901 ttcttaaatc agttaatgta actgcttttt ttaagttgtt tgtattctct tttaaggctt
    90961 catattcctc atagttagta acatgtttta ttttaccttt tacttccaaa ggcttcattt
    91021 cttttattgt gtattttcca aaatatgttt ttattttgtc acaatcttct ttgactaact
    91081 gaaccttttt taagagaagc tttttatatt ctatctcttt tagtatgatt tgttccttct
    91141 cttctagtaa gagttctaaa ttgtttatac tcttactttt tcttatttct tgaatctttt
    91201 taatttctat atcaatttct ctataaaagt ttattgttgc aatatcatag atatcaacct
    91261 gattatatat tctatatcca ttttcatcat ttttcttagg atttactaat cctttgtcct
    91321 cataaaattt tagtgtatct ctagatattc ctaaaaattt agatacttgt ccaattgtat
    91381 acattatatt ctcctattat tagataaatt ctttatgctc attaaacgta tttctattaa
    91441 caattacaaa atcacctaaa ctttgaagta tcaaagtcag catagtattt acaacctttg
    91501 gaattactct ttttatttca taatccaagt gtaaacttgt taatatgata cgttataaag
    91561 actatattgt ctacatattt ctaacaatga ttctttcact ttaagatgtt cttaaacata
    91621 tttaactttt atttttaaaa atttcctata cataaaaata ttcctttcat gataacagtt
    91681 ttattatttc aactatctgc taccataaaa ggaatatctt aatctttaaa cacattctaa
    91741 atgctctttt aacaaatatt atcaaattat tctaattcta ttgtttcata tttattagtc
    91801 ttagttttat ataaatttaa atataaaact atatattcac ctacttttaa ggatacaata
    91861 agtcttcttc taccagtaag agtaaatgcc tcctctactt atcacaaact ataattttta
    91921 tctcattggt atatatccac gatactgtga gtatgcatcc atagttgcta tatcacctaa
    91981 gaatactgat gcgatattga attgtggttt taaatatggg aactcctctt cttgtgccca
    92041 ttctggtttt ttaataaacg actttgtctc ttcaaccaca gctttatacc attcttcttc
    92101 cccttcaaac catagttctg atacacggtc aaaagcagtt gctccataat taatcattat
    92161 tttactactg acaaaacgat taacatagca acagtttgta aagtatggca ctacctcatc
    92221 atagaaccat ttttctcctt cttctttaga gataccatct ggatacttaa tcataaattg
    92281 ccaacgatag tttggtccat cttgtacagt acgtcctttt cctctaaagt cttcttccca
    92341 gtttattgga acaaaggcaa atataaatgg tggacatcca ttatctccac ctactgcacg
    92401 tcctgcatct ccactttctg cattttcatg aaccctttta ttttctacat ctggtataca
    92461 cccttgccaa cgtagaacat ccataggcat atattctgtc ataattctat ttgccatctc
    92521 aggcatatgt tcatctacaa gccaataatg ttctgttagt tgcatcttac gtgcaccaaa
    92581 acgctcacct tcatttggtg taggatatgc ttgataaaag gcatatttag tacaatatgg
    92641 tccaaaagtg ctaatactat ctggaatatg gtgacgatat aaccagtcca ttagcttagg
    92701 tctatattct tccttggcaa gtcctacata tattaaactt ctcattattt taaattcaaa
    92761 acccatagcc attctcctat aatcaaagta tattcacatg ctttcaattt ccctttttcc
    92821 tatctttact caaaatatat attgtaaaca aatctacacc tgcacccacg taccatactc
    92881 ctactgccat agctacagca atttgaatac aaatatcttg taaattaata atattttcac
    92941 ctgtcataat agttagacct atagcccaac cacaaagcca tgatggtagg aaaattattt
    93001 tttcaaataa ggatgcaatt acaactgcaa aaaaacctaa tatactaagt gttaaaaata
    93061 attctaggtt ttgattgaaa ttcatatatc ccataattaa aatggctaac actgcccata
    93121 aatctccaca ccaaaaacca aacattattt ttaatccatc tttttgttta ttaccattag
    93181 ttacatataa tcctgcacag attagtgcta cagctccagt ttttattcct atataaggtg
    93241 ctaatactgc ccataaagga ggtagtaaag caatccccat agacagtgtt aatatttctt
    93301 ttttctttct atccatttcc tatattgtaa ttagtagctt ccctagcttg ccttatctcc
    93361 aatagcttaa ttgctatttg atttacaatc atagatactg caaaataact taaatatagt
    93421 ggtataaata taacaataaa tgctggagtt aatctaacct tgtaatatgt aagtaccaaa
    93481 aaaataactg ctaaaataat ttcaatttgt ttaaaacttg acttttcatt catacaataa
    93541 gcctcctata acatctaaca taccttaaaa aagagtctta gtattttaat tattatccta
    93601 atgaaactcc agcttgcttt tctttagtta atggctctat aaaattataa gatgtttttc
    93661 tttctttaaa ttcttgtgtt ttacgaactt ctgcataatg accttccatt ttcttaatat
    93721 catcaccatg tataaactta cctggtaaag tatcatgagc atgacctaat tgctcttctg
    93781 gaaaactaaa tatagttttt ccacttatag tatctaactc tccaactata ccacatagag
    93841 cacaaattgc ctttttagta cctggctcaa ggtagaataa tctattgtgg caatgtggac
    93901 atacaccttc ttctccttga tatgaagctt tttcaaaatc ttttgctgct tcaactatat
    93961 ttaaaccaat ttgatgaact tgaacaagcc ttgtatcatc cattactaat tcctttgccc
    94021 atgggaacca agcattatct ataactttcc acattggtat gagagctagc atagcatgtt
    94081 cacattgaac tcttgtaccc cagtcagaac ctcctattcc cataaatgat attactttat
    94141 cattaagcat tcttgaatct ggaatttttc ctcctatagc ttctgcaact tttgttccta
    94201 taatgttatt tcctctatct gctctgggtc caaaacggtc cattatagta tggaataatc
    94261 ctgatgcccc ttcttcaaaa atagggtctg aaactactat accatctgca tctttcattt
    94321 tgtcaagcaa ccattcaaaa tcatctttta atacacacat actacctttc ccagataata
    94381 aagttttaac acacgcacaa catccagtac aatgtttaat gttaatagat gacatttgaa
    94441 taaattctac ttcagcccct gcttctttgg cacctttaag tgcaacttta cacattgtgt
    94501 cattatttcc attttttgtt ccaaaagaaa tacctagtat tttcattttc aactctccct
    94561 ctttagtatt tatttaatct tctttcattt ttaatatata gaatccatca tctaaagcat
    94621 ctatgatgat gtagcctcta tcatcaacga taagatcttc tgttactgcc aagcgtggtc
    94681 ctgggaatcc tgggaaataa gattcttctg gtgttttatt tggatttggt ggtataaaat
    94741 atgctagctc tttgatataa tatgggtctg atacatcata aacccttagc cctgcatgga
    94801 aataacagca atatactcta tctcctcttt gctctaacca tggcttatta tccattggtt
    94861 catgaagatt atgtgggcca aatggccctg gttttcctaa tcccgcaaca ttaaagttag
    94921 gataagggaa atcttttgga acttcaggat atggaaattg agcaattaat gttggttttg
    94981 ttgggtcact aacatcaacc atatgtatat tattcatagc ttgaacatct gtaatgttat
    95041 ctggtttaaa gaactggaat ctttctccct cattttgaac aacgactaaa tctcttcctg
    95101 gcaatggtaa tgctgtatga gttcttgcac ctgcaagtct actagaaaat gcaggcataa
    95161 atggcaattc acctaagcat cttggtcttg ttaaatcttc aacatctaat acaactaaac
    95221 cagctcctcc ataaccacaa tatgcttttc cgtctcttac aaatggaggt ccatgaagcc
    95281 atcctttatc cataaattct gggcaatgag gtgctcctgc atcaaaagtt ctatttggat
    95341 atccatttgc atattggtct ggtctccacc atttacctat ttccactgga ttagtaggat
    95401 ttattatatc tatgacccta taaatcagac cttcaaagcc aacacaatca cttgataaat
    95461 gtacatatct tccaccattg tacatgaatc tatgaacacc cattacatgc tttaagccac
    95521 aatcccaata tcctaaaaac ttaggattta aagggtcttc ttttaaacta tatattctaa
    95581 ttcctgcttc acacttaata tttgctaatt tagcttggtc aacaagtgct cctggtccac
    95641 ttccacaact cattgctact atcattaaat catctgctat ttgaattttg ggagttgttg
    95701 ttgtaggata ctctttaggg tctaacattt gaaaatgttt tataaattgt ggattataag
    95761 ggtctgtaat atcgctaatc attactccat tttttttatt tcctccaaaa cagcatccat
    95821 ataaatagta tttttcatct cttttgtaca gagccatttg aaacattcca caagttccat
    95881 ctaagttatt aaaggaacaa acttcaagat ttttaatata tccgttattt ccgttgcctt
    95941 ttgcataaaa tttatcttcc attttttctc ccttcttatt taaagtatta tcaattgata
    96001 tactttcatt ttatgagaca aacttactta aatccaatat cgttttcatt ggaatatata
    96061 agttattctt attaataaat ttataaaatc taatgtaaag atatacttaa aacatatatt
    96121 tttatacaaa tattttctaa tattctttaa aagtaaattt tcttatacta taataagctt
    96181 taattataga taaataaggt ttacaaacaa tcaagtttaa ataggggtga ttatttgaat
    96241 actaaacaat tagaatattt tatatctgta gcagaaaatc taagttttac caaaacagca
    96301 gaaaaatttt atatttctca aactgctgtt acacagcaaa taaaagcttt agaagaacaa
    96361 ataaatgtaa ctctatttac aagaagtaaa cgtcatgttg aactaacacc agctggaaaa
    96421 gtttttttat ctgaggcacg tactataata aaaaatatca atgatgctat tgcaaaaaca
    96481 caacaatttg cacatggttt ttttggaact ttgagcattg gaaccttaat aggatatgaa
    96541 aaaaacaaac ttcaacaata tttaaaagaa ttttctaata cataccctaa tatatctatg
    96601 gatatttgta ctaatgaaat aaccgaactt ttaaacttag taaaaaataa ttctatggac
    96661 ctcgcttttg ttattaatcc agaaaatcaa ccattaaaag attttgaata taaaactgta
    96721 gaaagatatt ctttggtagc tcttttacct cctggtcatc cactttacaa tgaggattct
    96781 atcgatttaa ttgaattaca acatgataaa tttatttttg taaaggaaac aggggatgag
    96841 tatggacaaa agtcaatgat acagaataga tatcgtgaag cagggtttgt acctaatgtg
    96901 gtacaacgtt caaataatct taatactatt gaatcattgg tatcttctaa catgggaata
    96961 tccattttac cttcattttg tgttacagat acaatgatag aacgtgatat tgcaatagta
    97021 cctataaaag aagtagaaaa tagaattgaa gttgtagttg tatggaataa aaaaaataca
    97081 aatccagcat tagaaaagtt catttctata atataaaatt aatcaatatt aacgataaaa
    97141 atagcattaa ccattttttc tatagttaat gctattttct actattttat tatttaactt
    97201 ttaatttaat atttataatc attaaaaata actctgttta acaaatataa gcaagtcaaa
    97261 aatgtgtcta aaaaagataa aaattttatt atatacaaat gtattatctc aatatatcta
    97321 ttttttcatt attcatcagt ctaagtacat gacctgtgct tactaaagaa ttatccccat
    97381 aagttgtatg agctaacacc gaactagcaa ccccaaactc aactatatct tcactcttca
    97441 tattttccaa atatgaatat ataattcctg ctacatatcc atctccggca ccaaccctgt
    97501 catatatttc tagcttatac tccctacttt caaaataacc atcatcattt gatatatatc
    97561 cctttataaa tctattattc atatcatcaa atcttctcat agttccagct acaatatcta
    97621 tatcatactc ttttttaatc aattctgaac tagattttat atttagacta tctatattaa
    97681 gtatcttatt tatatctcta taactagcaa acagcccatg acaatatggt agtattttct
    97741 tataatcatt tactaaatca tcataagtcc tttctggatt taatgattgt ctaaaattaa
    97801 aatcaaagaa tacttttatc cccttttcat aagattttct agctagttct aaagcaatct
    97861 ctttaactga atctgtaagt tgcatagcaa taccacaaat atggactata tccatttctt
    97921 ctaaacattt atcaatatca taatcttgta atttactctc acaaaatgaa ctatttaacc
    97981 tattcaaata agtcacttca gaaggtcttt ctccataccc attttcaaga aaatacactc
    98041 ctatatgatt ccctccatac gtgataaagt catcttttac tccaagcttt cttatatttg
    98101 cacttgatgc tttacctaca ttattattag gcaactttgt caacatatag gtattgtatc
    98161 caaagttttt aagtccagat aatatattta atcccgtgcc tgtagttata taatttagtt
    98221 cattggtttg tgttaagaac ttgtagtcag gtactgaaag tctcatcatt atttcaccaa
    98281 aagctaatat attcataaat ctatcccaat aattctttca ttattttata aagtactcct
    98341 atatcttcca ctttcgtttc acctgtttct ttatcaatta ttgatgtata aacatgaggt
    98401 ataacttttt ctacaccagc atcaagtgca atttgaacta tctctttgaa gttatctaag
    98461 tctatacccc ctgttggttc taaataaaaa ttatgctttg cacaagcttt tgcaacttct
    98521 atatattcat cctttgtttt aagccctccc attggaaaaa acttaattga gcttcctccc
    98581 atatctttca tcatagctat tgctgtttct ataggaacta taccatcttt ttcttttgaa
    98641 cttaatggac ctgtggatat ttttacaaat cctggtttac cagttggaga aactaatcca
    98701 tttattatac tatcattttg accaagcaat gctctagacg tagccacacc tgtaaacact
    98761 tgatttatat gttgtggctg aagttcttta gaaatctgag ataccatatt tgactgattt
    98821 gggtctccag ctccaagccc cacagatatt gcattatcta tttcctttga gtattttttc
    98881 atatcttcaa tagctgcttc tacagtgcta taattctttg atagtattcc tatcaataca
    98941 tgcccgtcac aagcatcata tacttcttta gcatttttta tgcttcctgc aagaacattt
    99001 aaacaaactc tatttttata atattgtggt atacaattca tatttatccc ctccattggt
    99061 aaaatttaat ttattaaatc attataatgt cacttactct acactctaac tttctactat
    99121 attttttatc ctattataaa tagtatctaa atcacttcca gttacacttc ttatatcaat
    99181 ctcaatcttg ccttcattag ccttatagtc tctagtgtat atagctatct ctccacttct
    99241 aagttcattt ataatttgtt gtgttgactt atttattata tcttcattaa agtcaatttc
    99301 tccacgaagt atttctctac ctgctgaatc cctagttata ctagcactca ctccctttat
    99361 agtatttatc ttgtctataa atggatttag cttatcctcc atttctttta aagttacttt
    99421 atcattactt atatatctct caattgcaca tgttagacct acaatatttt cttttcctat
    99481 tttcatagct cttcctatac cctttgattg aagctttaca ttatctatgt attttttctt
    99541 acctattact aaccctgagc taggaccctc tatagcctta gcaccactgt atatcactag
    99601 gtctgctccc aattcataat atacatttaa atcttcttct gctgctgcat ctactatcaa
    99661 aggtaaatta tattctttag caacttgtac tgcatctaat acacttagca tactcttttg
    99721 aacacaatga tgagatttaa tatacataat tgctgctgta ttttcattta tctctcttat
    99781 tatatgttcc ttgttacaca tattagcata accggcctca acaacttctc ctcctccaag
    99841 tcttatcatt acttctactg gaactccata atcaacatta tgtccctttg gaattattat
    99901 ttccctttta acttgtttct taggattatt tacattgtaa actagactca tatcatcttt
    99961 tgctatcatt gctcccacac tctgtgcaat cccagcagat gcactagaaa ctattagtgc
   100021 actttcacac cctaataaat ttgctatata ttcacctgtt ttatttataa gttcttctat
   100081 tataaagaaa tttttacacc cttcacctat tgcttcaata acttccttat ctactgttga
   100141 tactcctagt atagtcattt tgcctgaagc atttataaca cgtcttacag agtatttttc
   100201 aaatatacta ctcatacaat agtttctccc ttctactcat tctctcctat agacttacct
   100261 atatttaaat attctccatt gactactact gctcttggct ttatagacgt acttgtgatt
   100321 actgacttat tcaaagaatc ttgaagttct ttttcttcat taaccacatc aaatatagtt
   100381 aaatcagcat catatccttc ttttattaaa cctttatttt ttaaacttat tgcatctgct
   100441 gcatttttag taactttatc tattatatct tcaagtgaat agcccatata tataaacttt
   100501 tccattgttg tagatagatt atacactgga ccatttattc tatttttaat atatatatct
   100561 gtacttatag tgtctggaaa aattcctgca tccttagatt tcattgcaat atccatacta
   100621 aaactttcgg ttccatgacc tacatcaagg attatacctc tttctctagc ttctatgatt
   100681 tcttttttaa cctcattgcc tctaagtatt ccatttggct ttccattata tatatgggtt
   100741 aatatatctc ctttttccat atagtcaaat atatcctcta tcgttggagg agaactccca
   100801 aagtgaacca tcataggtag attaagttca ttttttattc ttttagctac ttttaaaggt
   100861 tcaacatcat ttgaaattac aacactttta ctcattctag ctttgattcc aacaacaaaa
   100921 tctttgtatt ttttaactgc tcttctaagt tcatattcat caatattcat catacttgaa
   100981 agttcatctt gagatgttat tccctgctta gcaatattta ttaaagcata tacatttgtt
   101041 ttatattttt tagtatcttc ataaaattta cctatatcta aagctcctgt tgttcctgca
   101101 tctactacag tagtaacacc gctttttatt ccaacctcat ctggataatc cttataaagg
   101161 tctagtcttt cgtagcagtg cgtatgtata tctatccaac cagcactaat aaatttttct
   101221 ccatctaggt ttataatttg atttgcctga tacttagaat catctatctg attttttact
   101281 tctattattt tatcgtctaa tatagctata tcaattatac ttttatctac tgtttttcca
   101341 cattttatta atatgtctat cttcacttta ctctccctct aaaataagtt taaatttact
   101401 ccaaggttca ataaagtcta aaagtattat ttcgtcttcc tttattctac ccaccttatt
   101461 ttttctttca tctgcacaat cttgaagtat caactgtaat tcccctttat actttccaaa
   101521 gtcatcatta ccaatcacta catctcctct tttaaagatg gtcgtattat catgcttagg
   101581 gaaattttct ttagcatatt tttttcttac ttctgtagac cttgctactt ggttggttat
   101641 atcccctctt ctaaagtgtt gctcatttgc cattattgtc ttttctactt cagaagtttt
   101701 ttcttcagtt actacattaa atacaacttg atatttattt acttcagaca ttctttttaa
   101761 ttcatcttca cttgcatatg cattccctac aattacatca tcaatcaatc ctgttgcgaa
   101821 taagtgcttg gttgctgtag caatatctaa gtttctatgc atttcaagcg tacacagccc
   101881 atcatttata ttccaaggcc ctattgttgc gtattttgaa ttaacaaaag cagcagttct
   101941 tattccatac tttttaaatc tatttgaaca tcttacaaaa aaatcatatg gcaagcctgt
   102001 acccctttga ggataaaaat tgtgacaacc atatatatta tttacatttg gcttgtaagt
   102061 aattatatta tccaagtatg ctacatcatt actcatattt agttccactt ttaaatcata
   102121 tggattgaaa gaaatcatag cttctttact tccatcatat ccatagtcaa gccttattcc
   102181 actagcattt aactcactaa aaaatgttaa atcatcataa gatatttgta atatatcaaa
   102241 tatgtttgga gctatatcaa ggattacttc aaatcctaat tctcttgcat aggttataat
   102301 ctctttaaaa tgttttttaa cttcttcctt aggtcttgta attgaaagca tgcacataaa
   102361 tattctttta aatccgtatt ttgaagccat ttttatatat gccttatcat cttccatgtt
   102421 actatgctct ggatatactg atattcctaa tcttctttcc atctttctcc tcctcaaatt
   102481 acattattta aaatatataa aattaaaggc aaaggtcatt cctcctacct tcacccttaa
   102541 taacttataa gctttttcta tattttatat agtacaaaac ctctatatct atgtattttt
   102601 ataaattttc actcatttct tcttgttctc tttgtaattg ttgtttttca aaaactttga
   102661 agaatggata ataaacagca aatgatatca caaagttgat taatactaag atacctgcta
   102721 gtatactcca gttagtactc attactgctg ctattggtgc tggcattgca aatggtaatc
   102781 ttgctaccat cataggtata acccctgtaa tagtaagaac atatgataga attgtcatta
   102841 ttataggtcc aattataaat ggtatcccta gtattggatt cataactatt ggtgctccaa
   102901 atattatagg ttcatttatg ttgaataacc ctggtaaaaa tcctaatcta cctaaacttt
   102961 ttagatattg tgacttagaa aacataaaca ttacaactaa tgcaagagta gcccctgctc
   103021 cccctatcca tacataccac tgtaaaaatt gttctgtaaa tatgtttggc attgcatgag
   103081 ctgatactcc ttctgtgaat gcagttatat tttctgctat agacatgtcc catataggtc
   103141 ttattactgg tcccattata gctggaccat gtattccaag tacccagaat aaagttatta
   103201 ggaatactgt cagtaaccca ccacctaaac tatttcctga taagaatcct tttaaaggtg
   103261 ataacatagc gcttagtgca acacttatat caaatcctag aatatgtctt attacccaga
   103321 ataacattaa aattactgct gtcggtaata atgcagtaaa tgaatttgaa acctctactg
   103381 gaactcctgc tggcatctta attgtaatat tcttttcctt cataaaacga tatatttcaa
   103441 ctgtaattaa tgatgttacg atagctccaa ataatgatgg cgaattaagt tttgccatat
   103501 ccatccatct accagcttct ataactccac ctactggttc aactacttga gttggaacta
   103561 ttgtagaaac taaaaatgcc ataactgcaa gcataccaac acctgttgta tctaaatcgt
   103621 agcttttagc aagtgatgat gctatcccaa aagtagcata tagagataaa aatcctacag
   103681 tatatctaaa tggtatatct aatattgctt taaatggagc tataaaatcc atataagcat
   103741 caataggtat gtttaataat attgtgaaaa atgaccccac tattgttagt ggtaatgttg
   103801 ctattatacc tgctcttaca gctctcatat gtctctgatt acttatcttc gctgctacag
   103861 gcataatctt gcgctctaaa aaacttgcga atttttccat agttatcccc ctgtattatt
   103921 gatattatcc tttatttata atgcaataac gatttcataa cataaactaa tttttatgta
   103981 attgataata tcacttgttt attaaaaata ttataacatt ataatgtttg gttgtaaaca
   104041 ttataatgtt ataatatttt ttatttttac aactaaacaa aaatcctgag catattatca
   104101 tttcaataaa ctcaggattc ttattatatt tcgtatttaa ttacatagtt ttgtacttct
   104161 gtattatatc ttgcaaatga tagctcaact atattatcat tctcatcata ggtctttctt
   104221 tttcttccta ataatatgtc tttagctaga tttaaagcct ttgatacctc tagttctgat
   104281 tcttctataa aaaattcatc ttcaaatcta gttatattta tatttctcct atataagtac
   104341 atatataaag aactttcatt attaaaactt tcaacagtta gattttcatc aaaaggaata
   104401 taatgagtaa aaaatatata tggcttacta tctaaataat acattctagt aatcttgcta
   104461 catttttctc caaatatact aaatacttgt gaatttgtat catttattat tttttcaatt
   104521 gaaatagtct ctttagataa cttatgacct ttagataaaa gtatacttga aaaagactct
   104581 gcttttgata gcttattaaa aaggctatta cttattactt ttgtcccttt tccacttttt
   104641 ttctctacat atccttctga ttctaatatc tcaatagctt ttctaatagt aattttactg
   104701 actccaaact cttgctctaa ctccctttct gttggaatat tttcatcaat tttatattcg
   104761 ttatttaata ttttttgctt taatatatct acaacttgta tatataatgg ttgatttctt
   104821 aacatgattc acctcttaaa ttatatgtta taatattata acatataatc ttatattatt
   104881 aataataaat atttattaac tttaaactaa atataaaaag agtcctcaaa ataatcctaa
   104941 tgtattactc actaaatatt gaatcaataa tctaacaatt agtgtgctac acataatgta
   105001 tcttttaaga actctcttaa tttattatct ttaattttta tttatcttgt aatttcaaat
   105061 gtaaatcaac gatttcctca gctaactgtt gaaaattcat gccattcatt aagtggtcct
   105121 gtgcatgtat aagtatgaca cttatttcag tcctgtttcc actagcttcg ttttgtatta
   105181 attctgtttg atatctatgt gctttattta taacttccct agactctttt aataattctt
   105241 ttgctttttc tatatttcca ttcttagcct cttttattgc ttcaaaagct aatcctttac
   105301 cttcacctgc ataacctatt atattaaaag atatttctat agtcttttca tccatccttt
   105361 gattctccca atttatatat taaaaataca ttataattta tattacttag tgttgttaag
   105421 ttctatcgct ctatttaaaa cagcttctcc attaactgtt ccatagtgca tcatatttat
   105481 aacttctact ggtatattat atggcttagc aatttcttga gccttaggta atacatatct
   105541 aacttgtggt cctagtaata atacatcaca tttttctatt tcattttgta tagttgattc
   105601 tggtattgcc caaatttgcg actctatacc attttcttta gctgcacttt ccattttagt
   105661 aactaataaa cttgtagaca ttcctgctga acaggccaac attattttta tcatatattt
   105721 tcctccaaat ttttattaac aaccatataa acattataat gttataatat tttatttaat
   105781 tctaccttaa atgcaatata ctttcaatac ttttttgtta ttttaatatt attaagtgtc
   105841 aaattaacaa aaaccgtatc atttatttat gatacggttc tccattattt atcctataag
   105901 ccctataaat ctgttctaac aatatcaatc tcatcatctg atgaggaaaa gtcatcttag
   105961 aaaaggataa cctataatca gcccttccta aaacctcatc agaaagccct aaagaacctc
   106021 ctattataaa acagagacta ctattacctc taactgctaa atcactcata gtcttagcaa
   106081 gctcttcaga ggataaaccc ttaccatcaa tagccaaggc tataacataa ctattatgct
   106141 ttatcttccc taaaattttc tttccttctt tgtcttttat aatttccatt tccttaacac
   106201 tcaaattctc tggagctttt tcatcatcca actctataat ttctaactta caatacttag
   106261 aaagcctttt cttaaactca tcaataccta attttaaata tttttcttta attttaccta
   106321 ctactactat acttatattc atatatttct cctaaactta attttattac aaatctatgc
   106381 attactagaa tttacaagct cttataaaat tatatctctc tttcttgatt tgcatattct
   106441 acaaactctt caaaaggtat tgctttgcta taataatatc cttgatatat ttcacatcct
   106501 aaaccatata acttatccct ttggtctata ttttcaacat actcaacaac tatatcaaaa
   106561 tctaaatttt ttgaaagatt tacaatagtc attataattt cactacttct tttatttgta
   106621 agtatctctt taactaatga accatccaat ttaactatat caaagttatt attttgaaga
   106681 tatataagag agctatgccc catcccaaaa tcatccataa ttaactttat tcccaagtta
   106741 tgtatcgcat tgatacgttc aataattatt tgtgaacctg ataatgcaat ttgctctgtt
   106801 atttctatac ctaacatatt aggatttata tcattactac taatgatatt ttttatttgc
   106861 tctggtaact tagggtcatc aagttggtct ggagatatat ttacagagaa cttaacagga
   106921 tttctcaata gcttttcact cttctttaaa tcaatacatg ctttattaat aatatactct
   106981 ccaagctcat ctaagaaccc ttcttcttta gccaaaatta taactagtgg tggataaatg
   107041 aaccctccta ttgaatgttt ccatctaagt aatccctctg ctcccacaac atttccatta
   107101 taattgactt gtggttgata aaaaagctct atttctcctc ttttcatagc aaacttcaag
   107161 tctgatgcca acatttttga aattgaacct attttaccat tatggtttag aagattaggc
   107221 tgttcacctg ttaattcata cctttttaat aagtttgtta aattttctat attattttta
   107281 aacatatatg tatatctatt ttgcgacatt tttataaacg gaatataaat cataacacca
   107341 acacataaat taaatacttg caacaaacta cctcttattg aacctgtaga catatatcca
   107401 cttaaaaata taggtgaggt ccattctaca gctgaaactg tacatggtac aatacctgta
   107461 gacatagcca cataacttgt aacggttaag attataggag taattacaaa aggtacaaac
   107521 ataatatagt taaaaacaat tggtatcccg aaaactagca tctcattgat attaaaaaga
   107581 gctggtattg aagcaatttt agctaacttt cttacattta tacgtttttc actaagaaaa
   107641 attgcaatta ctaaacatag taaagagcca catcctccca ataaaaccat tgtatcaaaa
   107701 aaggtcttag taaaaatttc tgttggtaat tgattattat taactaaatt tatgttaatt
   107761 gccatactat tttcaaataa attttttgcg acggtatcta atacattact accatgaatc
   107821 ccaaaaaacc acataaagtg cattaaaaaa ataaacaaca gagcactcat aaggtttgtt
   107881 cccattttat taaaaacatt tgaaaataaa ttataaaata tatcttgaaa gtttgaactg
   107941 ccaattagac ttatcattac cactctaaaa atagaaaaca aaaatactac tattatgaaa
   108001 ggaactatag ccgaaactac catattaaag tctgcatcag ccccttctgt atgaaacttt
   108061 acacttgtaa caaaagattc tgtaagtttt acaaacaata cagaagatgt catagaaaca
   108121 attatagatg taaataacca ctttgtttta aatatttcta tataagaatt aagctcatta
   108181 ccatgtgaaa atactaaaaa agagcacatt gcaactatag gaacaagtac tgtatacttg
   108241 ctcccatata tttttccata actatagctt attgttaata atattattaa tgaaataatt
   108301 cctaaagtag aatcatttat aaagttaaga atatttgtaa cctctccatt aaacaagcct
   108361 gataaatatt cttgataagc ctttattgga agattcaaaa ttacaagagc agttgaacca
   108421 gtcataatag caggtatcgc taaaatcata ccctgcttta tagagtataa aattttatta
   108481 tcctcaacat tttcaaaatt tctctttagc aaagttattc acctctactt catctcataa
   108541 acattagaaa catcatttcg tgatagtaca tctagtttta catcttgtcc aactactata
   108601 tcatttgatg ctaatactcc ttttgaagtc tcatacgcta actcaggaaa attattttct
   108661 ttgcttaaat gtgctaataa tatagattct gtaccttcat taataagttc aacgcagaaa
   108721 ttagctgcat cttcattgga taaatgacca gtacttgaca ttactctttt ctttaaagca
   108781 tatgtatatg aacccatcat aagcatatta gggtcataat ttgattccaa tactactaat
   108841 ttagatttat atagatgttt ttttatattt tgagttatac atcctatatc agtagctata
   108901 gacatttttt catcactctc tgtataaaaa ttatatccaa ctgggtcaga cgcatcatgt
   108961 tctattgaaa aaggtcttac tatgatatca cctaatgagt aggttttatc attttcaaat
   109021 actttcatat ttttatcttt gatgtcacct aatttgtcct tcatagaaca ccatgttttt
   109081 atattagcaa atactggtat atcaaacttt cttgataata tacctgctcc ttttatatgg
   109141 tcaacatgct catgtgttat aaatattcct tttaatttat ctgcatctac accaatgtct
   109201 ttaagacctg tagttattct cttgccactt aatcctgcat ctactagtat attagtattt
   109261 ttatacccta tatagtggca attaccacta ctaccactcc ctactgaaca atactttagc
   109321 attccttcac ctctttttct gccttataaa ttatattata ccaaaaaaac agagtattaa
   109381 ataaaattta atactctgca caaaatttac ttacattcac tatttactta cattcactta
   109441 taatcttatt tatatctaca cctttactat tccatagttc cacaaaagct cttccattag
   109501 catttttatg cttatattta ttatagtact catttaaagt ctcaaagaat actttatctc
   109561 caacttcttt tcttatttca ttaaatgcta ttgcgccttt tgtataaaca ttcaagctgt
   109621 attcagtaga atttttatac tcatttgctg gcttaaatat attttcactc aaataacttt
   109681 ttgtctgtat ctccatagtt tttataagct tgtttgccat atctttacca tacttttgtt
   109741 caaaataaac tattgtagaa tattcagtaa gtgcttcatc taaccagggt tcacttattt
   109801 catcatttcc aacagcagaa taccaccatt gatgtgctgt ctcatgggca ataacatatt
   109861 ctagtaaaaa ttcatttttt tcattatata aactttggtc tatcataaca agcatagggt
   109921 attccatccc ccctataaaa aagtcacttg ctacaacaga aaattctttg taaggatact
   109981 ttccaaataa ttcactaaat atatttattg aatcttttgc cacttcagtt gcttttttag
   110041 aaagcttttt atttaaatta tatgtattga tagctactcc ctttgaatct actttgttta
   110101 catcaaattt actacttagt ataaatgcaa aatctctaac gttttcagct tctatttcat
   110161 atagcatttt cttattatca tgtttatcat caataagttt tcctgtatga gcaattttat
   110221 atttatttgg aatcaatagt ttcacatgaa aatcgctagt ctcactataa aatgggtcgc
   110281 caatagtttc ataactcttt aaattccatc ccctttcatc atttacacaa gctataggaa
   110341 accaattagt aacatttata gtattttctc catatccaaa tcttccaatt gaatttggta
   110401 tttttacgtt atattttata tctaatgaca ttctttcatt tggttttaac tctttcccta
   110461 attctatttc taatatgtca tttttgtctc ctttaatttt atactccatt ttactattat
   110521 tatttaatat attctttata tctatatatc cttcgttaaa tccattagga taagcccttg
   110581 tcatttcact tttttcaaaa ggagcaaaat ctttcttgga aaaagcattc ggatatatat
   110641 ggaaatatat tttatctatg tttgattttg tattatttat gtagtcaaca ttctgattgc
   110701 acattaacct cttagtctca tcatcaaata taacatccat attatactga tttatttttg
   110761 aattagtttt ttctttgtat gtttctaaac tgtcatcctt ttctataaag caacctatta
   110821 ttaataccat aaatagaatc gctactgata atgttcttct tactttttgg ttgaatttta
   110881 taaccaaaat atctcctcct tttcaaaatg aatactttta gaaaatattt acatgctaat
   110941 cttgtgacct tttatttgtt tacagacaaa tataatataa aaaatgatat aatttaatct
   111001 gaggtgataa aatgtttttt aaagaaagca atgaaataga tttaggtgaa atcactattc
   111061 ccaatatctt tatagatata tttatgccaa tggcggacgg gttatacgta aaagtttatc
   111121 ttttaggata tagacaagca tgtgatatta cttctaatcc taagttcgac aataattcaa
   111181 tagccaaaaa cctaaatata ccattgtctg atgtgttatc tgcttggaaa ttctgggaag
   111241 aaaagaagat tataaaaata catgacaatg aagaatatga taattttaat tattcaatag
   111301 aatttttaga tttaaaaaat ttctatattg agaatatatt aagcaataat tcatctataa
   111361 aatctaatac agataaagtt gtatctactt ctgaaaatcc aagtattaga aaaatgttta
   111421 attctataaa taaaatagtt gggcgatatc tcgacccaag tgaaaagatg agtattatgg
   111481 atataatgaa taaatacaat atgagccccg atatgatact ttgcgcatat gaatacgtca
   111541 aagataaaac tggtacatca aagccagtta aatacattga aggcattatt agaaattggt
   111601 atgattcaaa tttatatacg ccaaaagatg ttgaagaaag ctttttggta agaagtgaac
   111661 gatatatttt atataaaacg attttcaatg aattgggatt ttcaagacaa ccatcaaaat
   111721 cagaaaaaga acttatggac acctggtttg ataaatttaa tatggatata gatttgataa
   111781 taaatgcatg ttctaagtct aagaatattt caaacccaag tatatcttat ataaatggta
   111841 taattaaaaa ttggaatgaa aaaaatataa aaaatttaaa tgatttaaag caaaaagagg
   111901 aagaacgtat agttaaggag aatattaata agaagcagat taatactact caaaacaaca
   111961 atacttacaa aaaaactaag tttcataatt tcaacgaaac attcactcag tatacctctg
   112021 atgagctcga tgagattatt aaaaaaagtc aaaaagaaaa gtttaagtag gtgattaaat
   112081 gaatgaggat aaaataagaa aaatacttgc taaatatgct aagagaagag atgataatga
   112141 actcttatta gaacatagaa aaaatgaggt atataataga atccctgaga taaaatctat
   112201 agatgatgaa atttctaaaa taggtctcag tttagctaag atagtacttt taaatcctaa
   112261 gtctaaagat gaaattgtaa agaagactaa agagaatata gaatctttaa aagtaaagaa
   112321 agaaagactt ttagctgaaa gtaacatacc tcttgattac ttggaaataa agtttcaatg
   112381 tatttcttgt aaagataaag gatttttacc taatggagaa aaatgttctt gcctcaaaca
   112441 agaaattgta aatgaagctt ataaaatgtc taatttagat aggattttaa gtcaggaaaa
   112501 tttttcgaat tttaacttga atatattttc tcctaagaaa ggctctgatg gtgaaatatc
   112561 tcctagagaa aatatgctaa ataatttaag tatctgcgaa aattttgttc atgattttaa
   112621 gaaggataat agtgaaaatc tactgtttta tggttctact ggactaggaa agacctatat
   112681 gtgcaattgt attgcaaagg aattgttaga taaaggcaat gttgtaatct atcaaacttc
   112741 ttttagaatt ttagatattc ttgaagatta taaatttaga agagacacaa ataatcaaat
   112801 aagtgaagat aattataaaa acttgtttga ttgtgattta ttaataatag atgaccttgg
   112861 aactgaactt aataattctt ttactagtgg agaaatcttc aatattgtaa atacaagact
   112921 tgttgctggt aaaaaaatca ttatttcaac caacttaaca ccatctcaaa taggaaatac
   112981 ttacactcaa agaactctct ctagaatatt agataagttt aggattttag aatttactgg
   113041 agatgatttg agatgggaaa gatttaaata aaatagccct taaaaaacat ttttttattt
   113101 ttaaatagag aggtaagagc aaacttgctt ctctgtttaa aacttatatc acataaatta
   113161 aaacatactt tttatttttc tatttacata tctaatgtac cttaatctaa caaatcattt
   113221 acattcttag tagtctatat ttattgatac tataaattaa atttgctata ttacataata
   113281 ttatgctaga atgattctaa attttatatt taaaactatc acattgcaag taattcaaaa
   113341 ttttgttgta tgtttaattt catttttaat acaataaaaa tgaaattaaa aaaagatact
   113401 taaaagtatc ctgtaacata gaaaattata ttaatttgaa tttatgtact ttgtggagct
   113461 ggtgatagga atcgaaccta caacctgctg attacaagtc agctgctcta ccgttgagcc
   113521 acaccagcat ataatctagt atttatctct aattcaaaat ttggtgggac taacagggct
   113581 cgaacctgtg accccctgct tgtaaggcag gtgctctccc agctgagcta tagtcccata
   113641 ctggtgactc gtaggggaat tgaacccctg ttaccgccgt gaaagggcgg tgtcttaacc
   113701 tcttgaccaa cgagccatat tttggtgatc tatccgcgac tcgaacgcgg gacaccctga
   113761 ttaaaagtca ggtgctctac cgactgagct aatagaccac attttttcga cttttttcgt
   113821 cgtttctttc actcacaagt tatattatag cgtctatata atttttagtc aatagttttt
   113881 tttacttttt ttagaatata attaaaatca tctttagcca tttattttca acaaaattct
   113941 ttttaaaaaa cctatatgta tctacataaa ttcaacttta atttcagtta gaatatgtat
   114001 aagtagcttt aacttaataa aaaatcaatg taagtcaaat ataaaagagc atctctaata
   114061 actataaaca ttatcttgag atactcttct tcaactattt taaattattt aattgataaa
   114121 atattaagca aatatatttc ttcttattat agtttgagct ctatttggac caacagaaac
   114181 catatctaca cttactccaa ctagttcttc tatttttgct acatatttct ttgcattttc
   114241 tggaaggtca tcaaagttat ctatttgagt tatatcttca ttccatccat ctaattcttc
   114301 atatacaggt tcacattttg ctaaatcatc taatgaagct gggaaatccg ttattatctt
   114361 atcgcccatt ttataagacg tacaaacttt tatcttatca aatccagtta atacatcaag
   114421 taacataaat gaaatactag tcaatccatt aactctagct gcatacttaa ctataactgc
   114481 atcaaaccac ccacatcttc ttggtctacc agtagttacc ccaaattcat gtccttgttc
   114541 tcttatctta tctccagttt catttatttg ctctgtaaca aacggtcctt ctccaactct
   114601 tgtagtatat gcttttacta taccaacaac gtcttttatc atatttggcc ctatacctgc
   114661 accaattgca aatccaccag atgttggatg agaagatgta acaaatggat aagttcctaa
   114721 atctaaatct aataaagtcc cttgtgctcc ttcaaacaat acttttttac ctgctcttac
   114781 tgcatcatat acaataacag acgtatctgc cacatatttt cttatttgct ctgcatatcc
   114841 tagatattcg ttatatatag tttcaaaatc aaataattct tcttttccat atatattttt
   114901 aactatttca tttttagcat ctatttgagc ttttaatttt atagcaaatt tatctttatc
   114961 cattaagtca catattctaa taccagatct ctctgtttta tccatataac aaggtccaat
   115021 accttttttt gttgtaccta tctttaaatc gcctctggct tcttctgaca atgcatctag
   115081 ttctttatga tatgggaata tgacatgtgc tctatcactt atttttatat tttctgtact
   115141 tatattatcc gttttaaaca tttccaattc ttctaaaaat cctttagggt caaacactat
   115201 tccatttccg attatattca ctgtatttgg atttaaaact ccagatggaa ttagatgtaa
   115261 tgcgtatttt ttaccttcta caactaatgt atgtcctgca ttatttccac cttgccctct
   115321 tactactaca tctgcttgag tagcaagata atctataact ttacctttac cttcatctcc
   115381 ccattgagaa ccaacaattg caactgtttt catgtaattc acctctatat tttatatact
   115441 ctcgaacact ttacttactt attctatcaa acattcgtat ttttttcaac ttttttagta
   115501 ttctccaata tttaacatat attcttctat ttttgaaaac tcttctttct ctattatttc
   115561 tttttcatat tttataactt tttccataaa tttatccaca tctaaaagtt tttctaattt
   115621 acatatgtta attatatttc caaagtttgt attagtcatg tttatatgat actgattatc
   115681 cacattatta gcataaacaa caatagattc tcttaaatta ttgtcaatta ctctaaataa
   115741 gtttatttca tcaagtactt taattatatt gggatatata tattttaagc ttattttttc
   115801 catattattc ctcctaataa ttaatattta tacacagata aagcaagcca aaagcttgct
   115861 ttatctactt attcacactt atcaacaggc catctgtgga tagtgtggat agttttttag
   115921 ctaaatttca atgtttggac atatttagtg acatgtatcc acatttttcc tgtagaaaga
   115981 aaggacgttc tgtggatatt cgttagatta taggtctctc aacttatccc caaatctttg
   116041 aacttcacca agccaaacaa gttccacaga accagtttca ccgtgtctat tttttgctat
   116101 tattacttct cctatatttt tactctcaga atcagcatga taatattcgt ccctgtataa
   116161 gaacataact atatctgcat cctgttctat tgctccagac tctcttaaat cagataacat
   116221 aggtctatgg tctgctcttt gttctggtgc acgtgataac tgagatagtg ctactacagg
   116281 acagtttaat tcttttgcta atatttttag tgaccttgat atcttagata tctcttgttg
   116341 tctgctttca ttattacctt caccttccat aagttgaaga taatcaataa gcactaaatc
   116401 tagtcctttt tctattttta actttctaca ctttgacctt agttctgata tttttatacc
   116461 aggagtatca tctatgtgta ttttggcatc tgataatact gccatagcat ctataattct
   116521 aggccaatca ttatcattaa gtgttccagt ctttattttt tttaattcta cactagattg
   116581 tgaagataac atacgttgta ctaattgttc cttagacatc tctaaactaa atacagctac
   116641 agaggcatca ccttttaagg ctgcattttg aaccaagttt aaagaaaagg cagttttacc
   116701 cattgctggt ctagctgcaa ttaatattaa atcagtcctt tgaagaccat ttattttttt
   116761 gtttaaatct ttaaaaccag tagttatacc agtgacatca ctcttgttag tgtataattt
   116821 ttctatcata tcataggcat ccatcaaaac taagtttata gatttaaaat catcactagt
   116881 tttctcctgt gatatatcaa atatactctt ttcagcttgt tctaaaacat cttcaatctt
   116941 agttgctcca ctatatccta gatttattat ttcattagaa gcttttataa gctttctaag
   117001 tacagacttt tcttttacta tatcagcata gtattttaca tttgaagtcg tcggtactat
   117061 agtagaaaga cttgtaatat aactgattcc tccaatatca ttaagatgcc cttgttttct
   117121 tagttcttct gttaatgtta tcaagtctat aggctcacct ttattactta aagttatcat
   117181 acattcatat attattttgt gagcctcttt atagaaatca tcaggcttta tagtttctgt
   117241 aaccgttatt atagcatctt tatctagaag tatagaaccc aatattgatt gttctgattc
   117301 tacactatga ggaggaattc tcgtcatatc ttccatctta atcacctcta gttattactg
   117361 tttttctttt acatccactc ttattttagt agttactttt tgatgtattt ttatttctac
   117421 gaaagttgaa cctaaagatc ttattggttc atctaataat atttttcttt tatctacatc
   117481 tatgtctttt tgtttcttta attgctcagc aatttcttta gaagttattg aaccaaataa
   117541 tcttccacct tctcctgctt ttgaatatat ttctatatta atttcttcca tttgcttacc
   117601 taataaaact gcttcttcat actctttttg tgcttttatt tctttagatt tattcttttc
   117661 atttaattct tttattgcta cactatctgc ttgcacagcc atctttttag gaaataagaa
   117721 atttcttgca tatccatcac ttacttcttt catttctccc tttttaccag ttccttttac
   117781 gtcttttaat aatataactt tcatctattc ttcctcctcc aaatactcct ctattatttt
   117841 atttaccatc ttataagctt cttttagaga aacatttttt aactgtgctc cagctatatc
   117901 tatgtgtccc ccgcctccta atttttccat aagtacatgt acatttattt gtcctaaaga
   117961 cctcgcactt ataaatatag tatcatcttt ttcacctaat acaaaggaag cttctacttc
   118021 tttgatattt aataactcat cagcagtttg agctattata acatttatac tatctatctc
   118081 agtacttgaa tatgctaaac atattctatt attaattatt ttagtacttt gaattatttc
   118141 agcttttatt atgaaatctt ttacatcaga attgaagaat ttctttacct ctatagtatc
   118201 tgctccaact tttctaaggt aagaagcagc ttcaaaagtt ctaacacctg ttttgaatgc
   118261 aaagttttta gtatctagac ttatacctgc taaaagccct tcagctgtaa gtttatttat
   118321 tgttacatct tcatccatat actgaactaa ctctgtaacc atttcacacg ttgaggatac
   118381 atatatctca tggaataaaa gcactgcatc atttataaac tctacacctc ttctatgatg
   118441 gtctataact actaccttct ctgatagctt taacagttct tcacattcag tataatttgg
   118501 tctatgagta tcaactacta caactaatgt atttttagtg cagttgtcaa tagcttcctc
   118561 ttttccaata aacaactttt tatagtaatt attttcattt attttattta taaatatttc
   118621 tatagattca tttacagatt gtaaaactat gtttgcagtt ttgttacagg atttacatat
   118681 atcataaaca ccaactgctg ctcccatagc atccatatca ggatatttat gtcccattat
   118741 ataaacttgg tcactttgtt gtataacctc tcttaaagca tgacctatta atctggattt
   118801 tactttggtt ttcttttcta cagctttaga ttttcctcca taaaacacaa atttatcttt
   118861 tgtttttaca acagcctggt caccacctct accaagtgct aaatcgagag cacccgtagc
   118921 aagttttagg ttctcattta atgtatctcc atctatacca attcctatac ttatagtaac
   118981 aggaagatta tttccataat caatatgtct tattgtatct aaaatagaaa acttctcagc
   119041 ttccaatttt tttaactctt ttttatgcat taccaagaag aatttgtctt ttgaagttct
   119101 tctcaatgca ccatttgaat ttaattctaa agcagaaagt attttctcta cttcaacatt
   119161 aattaaagct ctcttatctt ctgctgcact ttttaatact tcatcatatc catctacttg
   119221 tattagcatc attgcatttt tttcatcatc ataattttgt tttactttta aatattcagt
   119281 cttgtctatc cagtataata tcatcaaata tttaggattt ttttcttgat cattttttat
   119341 aacattataa attattgtat attctttttc tttatagttt atttctgtgt acatctcttt
   119401 attttcattt aatacttttc ttaaattaag atttttaact atatcctcta tatttttatc
   119461 aagtaaatct ttttgaccaa tcatatcata aaactttcca ttataccagg atatatttcc
   119521 atcaaattct aaaatacata atggtattgg aagatttatt atggcttttt tagttgtttc
   119581 atctatatct aaagataaat tttgaatata ctctgtccat tcatgacgtc taatattagt
   119641 agttctccaa ttgtgaaaaa ccatatatac aaaaatacag aaaaataaac accctacata
   119701 caagttgtaa taaagcaaaa ttatactaga aataccaata acaattatat ataaatttat
   119761 ttctggcata tttaatttaa aggtttgttt attactcatt tctatcctcc taagtggatt
   119821 tatagcttct tacctttcta aagtcaatta tactatctac cataccaaca aaagatattc
   119881 ccataaatcc aaataaacat aaaattatcc ctgaaaaaaa cataatttta tttggtccct
   119941 gtcttatcca tttctttaag aaataaatgc aaactgctat accttgaatt acaaacatta
   120001 aattaaaaac tagctgtaaa ttagtcatta ttaattctgt atataatttt gaaccaataa
   120061 tttgaataaa taagactaat aaataaagta agaaagttgt gagtatagca tttcccggta
   120121 aataaaaatc agcaaactta ggaaatctta tattcatctt tgtaatcctt tttataaaaa
   120181 atacactcaa ataatatgtg acaaacgctg ataacaaccc ttgtaaaaat aacatcattg
   120241 gtagcatatt tgtaaaataa cttacaatct catctggctt cattttatca aacactttaa
   120301 gttcagttgc agaaaaacta tttttttgaa tatttacaat ttctgatatc atcttagaaa
   120361 cttcatctaa tagattcaca tttaaaaatg tctttaatac aaaaaaatat acaagcattg
   120421 aaagtacaaa tattatggtt ccaccatata tcggttcgaa tttattactg tcctcttgtt
   120481 caaagcttct ctttagcatc tttcctatta ctatacctgg taaagaatac attatacata
   120541 tatttaatgc ataagaaatg tctgcaaata gaatcagtac acaaaatgta accaaaatag
   120601 atataagaga atactttcta tcagtaatag cacctataat tacatatgga acagctgcta
   120661 acatactaaa tattcctagc attggaatat aggctattac taaagcgatt attatagcta
   120721 aaactattat agacattgcc ttagatagtc taattttatt attcaattta atatcactcc
   120781 ctattatcca tatgtttttt taaattagat aaatctccat accatctttc aacgctatgg
   120841 tcctcatcta taccaatttt tattttttcc ttgactttat aatccacatc tctaaaacta
   120901 attcctaatc tctttgctaa gagatatgtt atcattatta tatttgctaa agtatcttga
   120961 attgcttcat ctaatggttt taccccttta aacaataaat taaacaaatc acttacactc
   121021 attaatattt ctgttttcat ccattctatt atctttatgt ttctcgttat ctcagaacct
   121081 ttatctattt tcacgtttac aaccctcctt aatatataat attatatcat aaataataat
   121141 atatttaagt atataaacaa aaaaacgagc tttatagctc gcctcattta gatatataaa
   121201 tacatataat aaaaaatgag cacaaggctc atttttttag tctaatgtat atggtaaaag
   121261 tgctatattt ctcgctcttt ttatagcaac tgttaattct ctttgatgct tagcacaagt
   121321 tccagatatt cttcttggta atatctttcc tctttcagtt atatactttt gtaatctttg
   121381 agtacttttg taatctattt tagcgttttt gtcagcacaa aattgacaaa ctcttttttt
   121441 cttacgtctt tttttattca tcatgacttt tttccctcct ttttaaaatg gtatatcgtc
   121501 atcatctata gcttggaaac cttgtgggtc taaaccttga ggttcaaagc ttggctcaaa
   121561 agctggagca ctctctctat atgaattttc cgatttattc ttactatcca aagcttgtac
   121621 tgatctagta cttacttttg taaaagttct cttttcacct gattgtgtct gataattgtc
   121681 tactcttata gatccttgaa gtgctactaa tctaccttta gttatgtagt tagcacaaaa
   121741 ttcagcagat ttacccatta cttcaacagg tataaaatca gtttctttag atccatcttt
   121801 ttttacatag tctctatcaa tggctattgt aaaggatgcc actggtgttc ctgtacctgg
   121861 gatgtatctt aattcagggt ctctagtcaa ccttcccact aatacaactt gattcataaa
   121921 aacaccacct attttttata ataaaaccag ttattaagca acaactatca tgtgtcttat
   121981 tacgttttca tttatcttta agtttctgtc tatctcttta ggaacgtcta ctgctgattt
   122041 gaagttaact aatacataga aaccttctgt aaacttagct attggataag ctaatttttt
   122101 agttccccaa gtatcaactt taactatttc tccgtcagtt gcaacaactt ccttaacttt
   122161 gtttagtata gcctctctta cttcttcatc agagtttggc tttaccacat aaactaattc
   122221 ataatttctc actataattc acctcccttt ggacttaacg gctctacact cttagagcag
   122281 agaaatgaga ctaaaatctc atacctacac attttatcat ttattcttat ttctgtcaat
   122341 ttaaattttg gacaaagttt agtataaggt gaattatata cttttcaaac aaacaaggga
   122401 tggcaacaac catcccttgt attatatata agttattatt tttaattaag cttctacacc
   122461 catagcttct tttaatacag ctgctatatt ttttatacct tctattattt tttcttctgg
   122521 catatttgaa tagttaagtc tgaaagtatt ttctctacca ccattaggga agaatcctcc
   122581 tccagcaaca taagcaacat tcttatctaa acattttggc attaattctt tagcatttaa
   122641 attacttgga agctctaccc atgtaaataa tccaccttct ggatgagtaa atactaatcc
   122701 ttctgggaac tcttcttcca tagtcttaag cattacatct ctacgtttaa cataaactgc
   122761 ttttattttg tcaacatgtg catctaggtc atacatatcc ataaatttgc ttacttccat
   122821 ttgagatata gttgatgctt gtaagtctgc accttgtttt gcaaagttaa acttagataa
   122881 aatttctgga gaagcacaag tccatcctaa tctgtatcct gggcagaata ttttagagaa
   122941 agttcctaag aatattacta atccttttgt atccattgat tttaaagatg gtaaagtctc
   123001 tccttcaaat cttaaatctc catatggatt atcttctatt actggtattt caaatttatt
   123061 tactatttcc atgaattttt tacgtctttc aagtggccaa gttcttcctg ttggattttg
   123121 gaagtcaggt attacataaa tcatttttat tctatcagtt gtttctagta tcttttctaa
   123181 ttcttccatt atcattccat cagaatctgt tggaacatct atgaatttag gttgataaga
   123241 tttaaatgcg tttatagctc ctatgtaaga tggactttca cataaaatta catcaccctc
   123301 atcaataaat acttttcctg caaaatctag accttgttga gaaccacttg taactaatat
   123361 atcatctttg tttacattag ttttgttttt atcattcatt ctagctgcta ttttttctct
   123421 taatggttca tatccttctg ttgtagtata ttgcatagct gatcttccat tttcttcaag
   123481 cactgcaact gatacttttt tcatttcctc aactggaaat aactctggag ccggcattcc
   123541 accagcaaaa gatattattt gtggttgttg agtaagtttt aaaagctcac gtatttctga
   123601 tccttgtaat ccttgcattc tttttgcata tttaactgcc ataattaaag cacccccatg
   123661 aaaatgtttt cttcaattct tattatacca aaattttgga tattaatata cggtatttga
   123721 cattttttaa gtgttaaatt tttatcactt ttttattagc ttttttactc tcttttctaa
   123781 ggtctctcta tcaagcatta ttagccttga acatttagta cattttatct ttatatccat
   123841 tcccgttctt atgatttcaa actctttaca cccacatgca tgttgctttt ttaattcaac
   123901 aatatcacct atttttaaat ccattggcat aaataattag cctcctaatc taacttctct
   123961 acttcttttg agccattttc taatttactt atacaataaa ttccttttat atctacatta
   124021 ttttcaacta aaatagtttt tatcttttcc atatcttcaa aagaaaattt aattgatatt
   124081 ccacaacttg ctgttatttc tcttggtgtt ggaagagcca ttacttttag actattttca
   124141 ccaaataact tttctgatct tatcgcatga tgtgtcgaat taaatgacac tatatacatt
   124201 tgattcatta cttaatcctt tctgactatc tatttgagtt aatctttatt attaatttta
   124261 tattattaaa caaacataca ttatatagaa atggtatttg atgcattctt taatgtctca
   124321 actatagtat acatatttgt aactgtacct acttgtaatt tgtcttttaa attataataa
   124381 tctaaacaag taccacaaga taaaacttct acacccatat tctcaagtat ttttagattt
   124441 tctatggttt cttcattttc agcacttaat tttactcctc cattaactaa aagtacatac
   124501 ttaggataag gtttagattc tgttaatgta tatataaatc cttttattaa cacttttcct
   124561 aattcgtcat ttccaagtcc catcttatct gaagatataa atatacatgt attgtctaat
   124621 tcactttctt tattatctac aacattttgt ttatctagta tatttttacc ttttctaatt
   124681 tctatagata taaaattctc tttttcgtca acaatatttg cttcacaact taaagattta
   124741 gcaagtttta atatattctc cttagctgtt tcattatcga ctattgtaac tacaacacct
   124801 tcttctaggt tatccaattc tctttttgta tttataactg gtttaggaca agcaagccct
   124861 ctcgcatcta tttttatact cattgtctga ttcatctcct taaaaatatt catacaattt
   124921 atattttatc atagatatta tcttgcttgt tatagattgt ttctataccc ttataggttt
   124981 atttacccta cattatttct aaatttttgt acataaatac acctttttga taatattcta
   125041 actctttttc ttttgatata tttgaatata attgacctaa gtctatatat aaattggcca
   125101 atattctatt gttgcctaaa tctgatacta tttttatgca tttaatcaga tattcaattg
   125161 caagagttac ttcattctga tttttataca tattagcata gaatctcaat gctttatatt
   125221 cattgaattt atttttattt tttattgatg aagctaaggc tatcttacaa tattttctag
   125281 ctaaatcata atcttcttta tctatatatg cttctattat cttaaataat cctgacatca
   125341 tgtattcatc ttcatcattt ttctttatgt catatacctt ttgtgaatat tcaagtactc
   125401 tatctgtttc acctattttt ctgtaaacat cacaaattgt taaatacaca tttgctaatc
   125461 cagttttatt atcctcactc tcaagtattt ttagtgcttt tttaaagtaa tctcttgatt
   125521 cttcatattt tccaatctca agcatattat ttgcttttaa caccaaaata tcgacatctt
   125581 cttttctatc atttctatta tctatttcat ttatcttttc tatgtacttc aatgacatat
   125641 ttggattatc tagttttatg taacaatatg ccatcttact atatagttcc ttgtgtatgt
   125701 taacatcctc aaatttattc tctgacaaaa tttcctctgc aaaattaaag tggcttatag
   125761 cacctttata aaagtcttcc tgcatatata ttttccctat gtttaaataa cacttaagta
   125821 tattttcact atcactattt tttataaaga agtacaatgc cttttcaaag ttttctatag
   125881 catcattata attagatttt ttcaaattaa tattagccat taaaaaatta catctgccat
   125941 agttctccat taaatcgtat ctcttacata tatctaaaac ttcttttatt tggtcctcag
   126001 ccttgtttaa ttcattttct tttatataaa tttcgctctg tagtattaaa ttatcagtta
   126061 tcttttttga ttgcatttcc ttggtctcta ataagtattc tacacttaca tctagcttat
   126121 cgcctagata ttccaacagt tcataactag tatgagattt atccctctct atatggctta
   126181 tttgtgctgc tgttatccta tctccagcta attcttttaa tgtcatgttt ttttcttttc
   126241 ttaatttttt aatcttttct cctaagctca aaatttccat actattccca ccttttgaag
   126301 acattttttt ataatataat tataacttat atttatttta aaaacactac ttttatttta
   126361 caatattttc actgtacatt aaatgatttc ccataaaaat gactaaaatt tagtttattt
   126421 tgagttttat taatttaaat aaatcatttt ttaaatttgt tactattttg tattcatata
   126481 tttgctcata acgactataa ttatatataa gaatagtttt taagagagga gaaattttta
   126541 tgaaaaataa gaaaataatg ttagtgttaa gtatattatc tatatctata ttcgcagttg
   126601 gttgtactaa tgctcaaaat ggaagtgatt catctaaaaa agaaactaag agcaatacaa
   126661 atgttgagca accaaaagaa gaaaacaata ctgaaaaaga ggttcctaat aacaaagcta
   126721 aacctactcc aaaagaagaa actaaaactc aatcagctac tatttactct tttgatgtag
   126781 ataagacaga tttaattgaa aataaagttg atttaaataa aattgatgag aacactttat
   126841 ttgaagaact tcaaaaactt aaagttgttc cagaatctgc aaaattaaat tcatttacta
   126901 caaaagacat tgatggtgta aaaactggta tattagatgt tagctctgac tttacaaagt
   126961 caaacttagg tagtgatgca gaaactttaa tgcttgattc agttgctcgt acttacataa
   127021 aaaatatgaa tgttgaacaa ataaaaatta ctgttgatgg ttctaattac gaaagtggtc
   127081 atatagttct tgaagaagga gattacttaa agtaatttct tgaaactatt atcaaataga
   127141 ttagaggttc ttaggaaccc cttttctttt ttgtacaaaa aaggagatga ttcaaatttt
   127201 tattttgaaa tatccccttt ttttatttct atattattaa atctcatgct atttattttt
   127261 tgaaattttt ttcaaagctt ccactgcttt atctatctca tcttttgtgt tgaaatatcc
   127321 tatactaaac cttactgcac cttgttttaa agtacctaaa gtggtatgtg ctagtggtga
   127381 acaatgtatt cctgatctag tcgctatatt ataatcacta tctaataaga aagtaacctc
   127441 tccagaatcc atatctccta tatttagagc tattactgat gctctttttt tactgtcctt
   127501 tggtccatat atctttatat ctggtacttc ctctaatttg tctatcatat attgacataa
   127561 ttcttcttca tgttgtctta tattgttgat tcctctttca aatataaata gtataccttg
   127621 gttaagacct gctatacctg gagtattatg agttcctgat tcatatttat ctgggaataa
   127681 ctctggttga actatttctt ctgatttact acctgttcca ccttctttta atatatttaa
   127741 gttcaaccct tctcttacat ataatatacc tgttccttga ggtccaaata agcatttatg
   127801 acctggcatt gccaacatat ctatattaca ttcatttacg tctatatcat aaacacctgc
   127861 tgtttgtgat gcatctacta aaaatagtat attatgtttt ttagctattt ctccaacttt
   127921 ttttatatct attaaagttc cacatacatt agacgcatgt gttgttacaa tcagtttagt
   127981 attactcttt attgattttt ctaaatcttc ataatctaaa aatccctcat aatcgcattt
   128041 tactacagta ttttcaatac cccttttttc caatgctttt ataggtctta ttactgaatt
   128101 atgctccata gacgttgtta ttacatggtc tccttcttgt aatacacctt ttatcgctaa
   128161 atttaaagaa tctgttgcat tagatgtaaa tactatattc ataggattac ttacattgaa
   128221 caacttagct atattctctc ttgtatcata tatctcccta gcagctctca tagcaagttt
   128281 atggcctgct ctacctggat ttgcacaata atttttcata caatctaaaa cagcattata
   128341 cactctttct ggttttggat atgtagttgc agcattatct aaataaatca taacaatctt
   128401 cctctctgtt ttatattttt gttctattca agaagcattg atacaatact atttaaatca
   128461 tcatcattat agtattctat ctctatttta ccttttttct ttcctttaga aatattcacc
   128521 tttgttccaa atatatttct aagtttatct tcaacatcta aaataaatac atccttaggt
   128581 ttagattttt taggttcttc ttgtttattt tcagatattt ttttagctat attttcgact
   128641 tctcttacag aaagttcttc ttcttctatt tttttcgcta tttgaagttg caaatcttta
   128701 tctgcaattc tcaataaagc cttaccatgg cctgctgtga ttctaccact gtctatcatt
   128761 tctataacat cttgtccaag atttaaaagt cttagtgtat tagttatatg aggtctactc
   128821 ttcccaacag cttctgatat ttcttcctga gttacattgt aatgctctat taaactctta
   128881 tatgctagag cctcttctat tgaatttaaa tcttccctct gtaagttttc aattaaggct
   128941 atctccatta tatctttcat atctatatct ttaattatag caggtatttg atttttattt
   129001 gcaagttttg atgctctaaa tcttctttct ccagctatta tcatatattt attattttca
   129061 tccattttaa ccactattgg ctgtaaaaca ccataatttt ttatagaatc cgacaatact
   129121 tttatctttt cttcatcaaa ttgctttcta ggttgaactt cgtttggata tattttgtct
   129181 atatctatgt tgactatttc tttttctgaa gtttctcctt taatttctgg tatcaatgca
   129241 ctaagacctc tacctaatct attacttctt ttagacttat tctccatact accattcctc
   129301 ctcttctaaa tctataaatt cttctgctag ctccaaataa gctacagacc ctctacatct
   129361 tttatcataa taaattacag gttttccatg acttggagct tctgcaagtc ttacatttct
   129421 tggaattaaa gttgtatata cactaccttt aaagtatttc ttaacttctt caactacttg
   129481 tattgataaa ttagctcttc catcaaacat acttaaaaca acaccttgaa tttctatatc
   129541 agcatttaat cttgatttta ctaattttat agtctccatt aattgactaa caccttctaa
   129601 agcataatat tcacattgta ttggaattaa aacactatct acagcagtta aacaatttat
   129661 tgtaagcatc cccagtgagg gtggacaatc taaaaatata taatcatatt catctattac
   129721 cgcttttatg gaatttttta aaatatactc tctattagtt ttagatgtaa gctctatctc
   129781 tgcacctgat agttcagtag ctgatggaac tacatctaca ttctcaaatt cagtacttat
   129841 tattgcttct ttaatatgta acccatctaa cataatttca tagattgtat tttctacttc
   129901 gtttttatta ataccatatc cactagttgt atttccttgt gggtctaaat ctaatactaa
   129961 tattttcttt cccaaagttc ctaagctagc acttaaattt acatttgttg tagttttccc
   130021 gactccaccc ttttgattga atacagctat aactttgccc atgatgttcc cccctttaag
   130081 aattaaatta attttaaatg ttgaataggt gttttttaag tataaataat gtctataaat
   130141 caatttatat tacaaggctt atattacaaa aaaagattac tggtaagcag taatctctat
   130201 tttttaggga tttttacaac aacttccata taatctccct tatctatttc attatactta
   130261 gcatcaattc ctgtatttga tatagcatca aaggcctgct ttatagtatt tatgtaaatt
   130321 cttatactca tagcaccctt tatattctgt tttttatcag gctcttcttg aactttagtt
   130381 tcttctaata catcttgtat caatttttct gtttttttaa cagtcaattc attttttatg
   130441 actttgtcta acacactttg cattaaatct tcacttggta gtttaagaaa tgctctagca
   130501 tgtctttctg ttaaattatt ctctattagc ttcattttta tatcgtttgg aagctttaat
   130561 attctaagct tatttgctac agtagattga tttttgccca atttttctgc taattgctgt
   130621 tgagtaaaag catgttcttt tattaagttt tcataaccaa ttgcttcttc aatgaaattt
   130681 aagtcttctc gttgcaaatt ttctaataac gctagaacag cagaagattc atcgttcata
   130741 ttatttataa ttgctggtat ggttttaagc tctgctaatt tagctgctct taatcttctt
   130801 tctcctgcaa ttagttcata tttgccatct tttgctctaa ctgttatagg ttgaattata
   130861 ccatatacct ttatagaatt gctcaattcc tccaatgaaa cttgtgaaaa tatttttctt
   130921 ggttgatatg gatttggaac tacatcttct ataggtatct ccataactct tttatcttcc
   130981 ataacatacc tctcttattt tagatataaa ttatttttgt tctctatatg tacatacaaa
   131041 tttatttctg catctacttt aataattcct ttatttttgt ttttttacag taagcttaat
   131101 tatttcctga gaaataatta agcttaccaa taataaattt ttcattactt aataggattt
   131161 ttggctggtt taccagcttt tctagggtac ttaactggtg tttccatcac ttttttaaaa
   131221 actaatatat tatgatttaa atctacctct ggtaactcta catctatttt ttcaatatac
   131281 tccaatccta aaacatcaat agccttttgt gattcttcta gctctaaatt agcattcgga
   131341 ccttttaagc aaataaaata ccctccaact tttacaaatg gtacacaaaa ttccataaga
   131401 atcggtaatc cagcaacagc tcttgccgta gcaacatcat atttttccct atagtcttca
   131461 tctttaccaa aatcttcagc tcttccatgt ataaatgtaa tattatctaa ctctagtact
   131521 ctactaactt cctctaaaaa gtttattctt ttatttaacg aatctaacaa agtaagttct
   131581 aagctatcta aacatatttt caatggtatt ccaggaaaac cagcacctgt accaacatct
   131641 attatagaca tcccattttt tatatatcca ttctttacag ctgaaataga gtctaaaaaa
   131701 tgttttatat acacttcttt ttcatcttct attccagtaa gattcatctt tttattccag
   131761 tcaactaata tctctctata gattttaaat ttttctaaca tactgtcatt cgtatctata
   131821 ttaaaacctt caatcccgtt tttcagaagt tctatattat tcacctttgc cacctctagt
   131881 tcttctgatt tgttctaggt atataagtaa aactgatata tcagctggag aaacaccaga
   131941 tatacgagat gcttgcccta ttgaaatagg ttttatatca tctagtttct gtctagcctc
   132001 taatctaaga ccttctatag atgaataatt tattttctca tccagctttt tattctcaag
   132061 ttttttaaat tggtctattt gtttcaattg tttctctata taaccttcat atttagttat
   132121 tattacacac tgttctttaa cttctcttga aacatcttct ccagcgcctt tccctaattc
   132181 ttcaagcaat tcgtaagtaa cctctggtct ctttaaaaat tcatatagag atattccaac
   132241 ctttattggt gttgctcctt tttcttctaa caaactattt acttcttttg gtgtaactct
   132301 ttcatttttt agtctttcaa attctttctc tacagcagcc tttttattta ggaacctttc
   132361 atatctatct tttttaacta atcctatatc ataacctttt tgagttaatc tcatatctgc
   132421 attatcttgt cttaaatata gtcgatattc tgctcttgat gtcatcattc tgtaaggctc
   132481 gttagttcct ttagtaacaa ggtcatctaa taagacacct atataagctt ctgaacggtc
   132541 taatacaaat ggctcttttc cttctatctt tctaactgca tttataccag ccataagccc
   132601 ttgagctgct gcttcctcgt atccagaagt tccattaaat tgccctgcac taaataagtt
   132661 ctcaacaccc tttatttcca aacttatttt tagttgagtt gggtcaacac aatcatattc
   132721 aatagcatat gcaggtctca ttatcttaca attttcaagt ccctttatag ttttgtacat
   132781 atctaattga acttcaaaag gtaaactagt tgaaattcct tgtatataca tttctttagt
   132841 atttaaccct tctggttcta taaataattg atgtgatgtt ttatcactaa atcttactac
   132901 tttatcttct atagaaggac agtatcttgg accagtactt tctattactc cactatacat
   132961 agcagacctt tttaaattat ccagtataac tttttgagtt tcttctgtag ttcttgttaa
   133021 ataacaaggt tcttgttttt tttctatatt ttcattcata aatgagaatg gagttacttt
   133081 ttcatcaccc tcttgtaaag acattacaga gaagtctata ctatctctat gaactcttgc
   133141 tggagttccc gtcttaaatc ttctcattct aaggccaagc tcaactaagc tatctgtaag
   133201 atattttgca taccccaatg cattaggacc ttcataaaat gcaacttcac ccatatatat
   133261 ctttgagttc agataaactc cagtggccaa tattacagct ttagatttaa atgaacatcc
   133321 tagtttagtt ccaactccta ttacaacatt tccttcatga agtatttcta caacttcatc
   133381 catagctata tcaagatttg gttcatcttc taatgtcttt ttcatttctt catgatattt
   133441 aaatttatct gcttgtgctc ttaaagagtg taccgctgga cctttggcag tatttaacat
   133501 tctactttgt atatatgtct tgtctatatt taatcccatc tgaccaccta aggcatctat
   133561 ttctttaact aattgacctt taccagtccc tccaattgat ggattacaag gcattaatgc
   133621 tatggaatcc aaagacattg ttattatcaa agttttatat cccattcttg cagtagccaa
   133681 agcagcttca catccagcat gtcctgctcc gactactata acatcatatt ttcctgcttc
   133741 aaactttatc atttataatt cctttctttt caaaattaat gtttcatgag aaacacttca
   133801 aattttttaa aaatctctat aataaaaaca agtttacttt tgtacattac ttaccaatac
   133861 agaaattatg gaatatatta tctagtaaat cctctgttac tgtatcacca ttaatatatc
   133921 caagatagtc ccatatattt tttaaatcga cttctacaaa gtcaaatggc atactttgtt
   133981 ccaaagcaat taaagcatct gttgcagatt tatatgcttt actaagtgca tctttatgtc
   134041 ttgaatttgt tactactaaa ctagaattat ttttgatact acctttatat accatagact
   134101 ctattttatc ttgcaattct tctattcctt cttgttgtaa agctgatatt tttattatac
   134161 tattattttc tacatattta agtatttttt cttcttcaat ctcttgtttc aaatcattct
   134221 tatttaacag cactattgtt tgtttatcct taagtttttc taatatctct atatcttctt
   134281 ctgacaactt tctagatgca tctaaaacca ttactatcaa atctgcacta gtaaatgatt
   134341 ctttagactt ttcaacacct attttttcaa caatatcatc agtatctctt atacctgctg
   134401 tgtcaacaat ttttaaaggt atacctttta tgtttacaaa ctcttctata acatctctag
   134461 tagttcctgg tatatcagta actattgctc tattctctcc taaaatagaa ttaagtagtg
   134521 aagatttacc tacatttggt ttcccaacaa ttaccgtctt taagccttct ctaagtattt
   134581 ttccactttc agctgtatca tataattttt taatgtcttt tttaagttca tcagtttttt
   134641 ctttaagagt ttgatatgtt atatgctcaa tatcttcctc aggataatct atagcaactt
   134701 ctacatgagc taatatctca gtgactttat ctctcaattc tcttatcttc tttgataaag
   134761 aaccttctaa ttgattttga gcaacttcat gagctatatc agttttggct tttataacat
   134821 caattacagc ctctgcttga gataaatcta ttcttccatt taagaatgct cttttagtaa
   134881 actcaccagc ctctgctaat ctaacatctt ttgatagtat taattctaat atcttcttta
   134941 ccgaaataaa tccaccatgg caattaattt ctataacatc ttctcctgta taggaatttg
   135001 gtcctttcat atatgccaat aaaacttcat caattatatt ttcattatcc actatatttc
   135061 catatattaa tgttctctta ttgtattctt caatactctt tccagacata gatttaaaga
   135121 tttcttctgc aaccttcaaa gctttttctc cacttattct aagtatacct ataccacctt
   135181 ctccaggtgc tgtagctatt gctgcaattg tatcatctat aaacaaattt atcacctctt
   135241 aattcataat tttttacata tagatttaca tttaaccaat cattaatgat ttaataatat
   135301 taaaaaataa aaccccctaa tgtttaggag gttgacttta tcttttacac tcaattacta
   135361 atcttctata tggatcggtt ccttcactat atgtaattac atatttgtca ttttgaagag
   135421 ctgaatgtat tattcttctc tcatatggat tcatataatc taatttttta gtttttcttg
   135481 ttttcgctac ttctctagca actttattag catatcttat taaagattct tctcgttttg
   135541 atctataatt ttctatatct acaagtactc ttgtatgaga atctttattt attttattaa
   135601 gagctaatcc agtcaaaaat tgaatagaat ctaaagtttc ccctcttcta ccaattaaac
   135661 ttgcagcttc tttgccttca atatcaacca tgattaaatt atctttttga gatacattga
   135721 ctttggcatc aacatttgca tttttcaaca ttacctctat aaaattttta gctacatcta
   135781 cttccctctc gataacaaaa atttcataag taccatcttt agcacctata aaacctaaaa
   135841 accctttact tggattttca agtatttcta cttctatatc ctctgctttt aaattcaact
   135901 ctgctatagc tttacttata gcttcctctt tactcttact ttttattaat tttaggcttt
   135961 ttctcattaa ctttttcctc cttagagtta gcagccagtt tagcttttaa aggattcatt
   136021 attaagtaat attgagctat tgagaataag ttacttactg tccagtacaa tgtaagtcct
   136081 gctgggaata taaatcccca atagaaagac atacctgcca ttacatatgt cattactttc
   136141 atagagcctt gtaactgatc ttttggtgtc attacttttt gcatgacata tgcacttgct
   136201 cctgaaaata ctgctaatac ataatctggt gatgttaagc tttttatcca taaaaaccca
   136261 ttgtcagctg ctaaaaatgc agctttgttt gcaaaaacgc catgagcaac tggttctctc
   136321 aaaacgctaa ataatcctat taatatagga aactgtatta ataaaggtaa acaaccagat
   136381 agtggattaa ttttagcttc tccatataac ttaacaattt cttcattttg tttttctggc
   136441 ttatttttat atttttcttg tatctctttt atacgaggtt gtatatcttg cattgccttt
   136501 gttgacttag tctgcttaat tgttaatggt aataaaataa tctttacaag tatcgtaaaa
   136561 agtattatag aaataccata atgattaaca aattcaaata ttaccttaag aatcaatcct
   136621 aagaaatttc ctattatatt caattttttt atacctccta atagttactc tcttttattt
   136681 tagagggtcg taacctcctg gatgaaaagg atgacatttt aaaattcttc ttatcgttaa
   136741 atacatacct tttacaaatc catatttctt aaacgcctct attgaatatt gtgagcaagt
   136801 tggataaaat ctacaggtag gtccctttaa gggagatata tacttttgat aaaatctcac
   136861 taaataaata cataaattcg ataaatactt acttatttcc tttaatatat aaattatttt
   136921 attcaaagtc attaacctcc atatttatag catacaatta aatagaaata tccgttcttt
   136981 taactaaatt ttttatagac ttgtctatgt ctttaaaagt agcatcctta ctagataccc
   137041 ttgctataaa tactatatca tatccaggct taattttttc atcaatattt aatctgtagg
   137101 cttcttttat taatcttctt actctattcc tagtaatagc ttttcctact ttttttgaaa
   137161 cagaaatacc tactctacta taatctgatt tatttttaag tatatatatt actaaatatt
   137221 tgtttgcaaa agatttgccg tgtttatata cttttctaaa atcagagtct tttttcaacc
   137281 ctttagtcct attaaagtcc atagttaacc tccataaaca cagctatgaa ttgtaattat
   137341 ttacacaaaa aggccacctt tgcagcggcc cttttgtaat taatgagtta atctatttct
   137401 tcctttagct cttcttctct ttaacacgtt tcttccgtta gacgtcttca ttctttttct
   137461 gaaaccatgt tctttacttc tttgtctctt ttttggttga taagttcttt tactcattat
   137521 tttgcaccgc ctttcagatt ttattttccg tttataaaaa taataacttt accctcaaag
   137581 taaacataac acatataatt ataaatactt ttactactgt tgtcaacgag tttttgggac
   137641 gcttatatca caaaatctac catatatata ttatgtattt tttttattga aaatactagt
   137701 aaaaatctat ttaattttat tctaaattat ttttttcaat tatatacaca aataaagtaa
   137761 ttttaacatg tttatatttt tatcaacaat tagttaatat tgtggataaa ttagttacaa
   137821 atcattgaag tttgacatat attttgatat tataaatata cttgttgata atgtgcataa
   137881 atgttatcaa cttattagaa attattcaca gcttgtggat acttttgtgt ataactttta
   137941 agattactga caatactcta gttataatca ccatttattg tatgtttatg ttatttataa
   138001 ctttatctac atattgttta tatcttttca tattttttta ataatttata ctattattaa
   138061 tttatcaaca ccattatcca taaatttagt tattctgtaa aatttatata tatttttgct
   138121 tttctgttaa taactttgtg gaaaatatta attattctgt tcggaggttt atattatgga
   138181 tatagtttct ttatgggaca aaaccctaca attaataaaa ggtgacttaa cttcagtaag
   138241 ttttaatacc ttttttaaaa acatcgtacc attaaaaata catcttaatg atttaatctt
   138301 actggctcct agtgatttta ataaagatat cttagagaat agatatttac atttaattga
   138361 agatgctatt agtcaactgt cattaaaaaa atataatatt aaatttgtat tgagcgaaaa
   138421 agaggttgct gatttaaatt ctgatagcac agatttaaat tatagagttc tttaccccaa
   138481 tctaaatcca aaatacacat ttgatacatt cgttattggt aatagtaata gatttgcaca
   138541 tgctgcatgc gttgcagttg cagaatctcc agctaaagct tataacccac tttttttgta
   138601 tggaggagtt ggattaggta agactcacct aatgcatgct ataggtcatc atattgttag
   138661 tcaaaaaaaa gactcaaaag tagtttacgt ttcttcagaa aaatttacta atgaacttat
   138721 aaactctata aaagacgata aaaacgaaga atttaggaat aaatatagaa acgtagatgt
   138781 attactaatc gacgatattc aatttatagc aggaaaagaa agaactcaag aagagttttt
   138841 ccatacattc aatactcttc atgaagcaaa caaacaaata attatatcta gtgatagacc
   138901 gccaaaagac atacctacac tagaagatag gctaagatcg agatttgaaa tgggacttat
   138961 aactgatatt caagcacctg actttgagac aagaattgct atacttagaa aaaaggctca
   139021 actagaacgt atagatgtgc caaatgaggt tatgtcatat atagcaaaaa atattaagtc
   139081 aaacataagg gaactagaag gtgcattaac tagagtggtt gcttattctt ctcttagcaa
   139141 tagggtaata tcttttgatc ttgctacaga agctttaaaa gatattataa caacttctaa
   139201 aaatgaagaa ataaatgttc tcagaataaa agaaaaagta tcttctgtat tcaatttaaa
   139261 gatggaagat tttaattcta aaaaaagaac acgttcaata gcttatccaa gacagatagc
   139321 tatgtattta acgcgcgagc ttactgattt atcccttcct aaaataggtg aagagtttgg
   139381 gggtagagac catacaacag taattcatgc tcatgacaaa gtatctaagg atatagaaga
   139441 aagtgaagaa attaagacta aaatagacaa aattatatca gatttgaagg gataatttat
   139501 acacaattgt atgtttatat ctcttgaata acctgttaat actttttttg aacaaaaatt
   139561 attaacaaat tatcaagtct aaaataacaa agatattaac atcttataca catgttaata
   139621 tctttgtatt tataatgtta tacatactta ttaacattat caacaacacc tactactatt
   139681 actactatga ttttaactta tttttatata taaaaagcca gaggaggtta tccacattga
   139741 aaataatttg taatcaaaaa atcctagcaa atagaattgg aattgctcaa aaagctatta
   139801 atggaaaaac aacaatagaa ttattaaaag gtatacttat atctacagaa gaaggtcaat
   139861 taaaacttac tggatatgat gctgaaatag gaatagaaac ttatgtacaa gcagaaatca
   139921 tagaaaaagg tgatgttgtt gtagatgcaa ggctatttgg agatataatt agaaaattac
   139981 cagattcctt tgttgagata gaaactgatt cagaaaataa tatttacata aattgtgtaa
   140041 attcaagatt taaaattaaa ggttatgcag caaaagaatt tcctaaatta ccagaattaa
   140101 atgaagaaga tttatatagc atacctcaag aaatcctaaa aaatatgatt aaacaaactg
   140161 tatttgctat ctcacaggac caaacaaaac ctgttttaat gggagaactt ttagaaattg
   140221 tagatagaaa cttaaattta gtagcaattg atggatatag attagctgta aaaagttgtt
   140281 cggttgatag tttaactgaa aatataaaag tcataattcc tggaaagaca cttatagatg
   140341 taaatagttt gctttctgga gaggataatg ttaaagttgg atttaatgaa aaaaatgcta
   140401 tttttataat taatgatacg aaaattatta caagattgct tgaaggagat tttattgatt
   140461 ataaaaaatt attgccaaga gaacataaca gcagagttaa attaaatact aaggaacttt
   140521 taaatagtat agagagagcg tctttattgt ctcaatcaga aaaaaataat cttataaagt
   140581 tatctataag agataaagta atggcaatta cttctaatac agaaaaagga aatgtgtatg
   140641 aagaagttga aatagattta gatggagatt acctagatat agctttcaat tctagatatt
   140701 ttatcgaagg tttgaaaaat atagataatg aggaaatatt tatagaattt actacaaatg
   140761 taaatccttg tataattaaa ccaacagatg atgttaatta tatttactta ctgcttccag
   140821 taagaatatc atcaaatata tagcagacat gaaggagttg tcttttgtag aaaatttttc
   140881 taatcttaga caactccttt tataagcata tttatggtat aatatacttt tagtgtatca
   140941 ataggaattt gtttaaaata gtgacaagga ggaactatta tgactgaaat aactatagaa
   141001 tcagaatata taaagttgga tcaatttctt aaattagcag agattgcatc aacaggaggt
   141061 catgcaaaat ttttaattca agaaggttta gtgacagtaa atgatgaaat agaattaaga
   141121 agaggaaaaa agataaaatc aggagatata gttgaaatag aaggaactaa aataaaagta
   141181 ttgtaaaaaa aggagaactt tttgtgaaac ttaaaagttt gcaacttgtt aattttagaa
   141241 attataaaaa gttgcatctg gaatttaatg ggaaagtaaa tctacttgtt ggtaaaaatg
   141301 gtcaaggaaa gacaaatata gtagaatcta tttatatgct ttcttttgga aaatcattta
   141361 ggactaacaa agataaagaa atggttagat ttaatagtga aaacttatat attggaggaa
   141421 gtttttcaaa atataataaa tatagtctaa tagagctaat tattggaaaa gataaaaaag
   141481 ggataagaat aaataaagtt cctttacaaa agatacaaga actacttggc aacttaaatg
   141541 ttgttatatt ttctcctgag gatttaaggt tggttaaaga gggtcctaaa gaaagaaggg
   141601 catttataga caaagagatt agtcagatta tacctaaata ttataaatat cttaccaatt
   141661 ataataaaac actttctcaa aggagtaggg tgcttaaaaa tatacatgtt gatgaagctt
   141721 tattagatgt atatgatgat acgttagcaa agtatggaag ttatatttat attttgcgta
   141781 gagactttat aaaaaagata gctaatatat ctgaaaatat gcatatgaat ttgactaatg
   141841 gagttgaaag attatcaatt cgatataaaa atcaaataaa tataactgat gaagatacta
   141901 tagatacagt atataataaa tttttagcca agttgtcatc gaatagacct aatgatatag
   141961 aatctaagac taccagatat ggtatacaca aagatgactt aaatatattc ataaatgatt
   142021 tagatgcaag actttttggt tcacaaggtc aacaaagaac tgcttcaata tcattaaagt
   142081 tatcagagat agaattaata aaaaatgaag ttgaagaata tccagtatta attttagatg
   142141 atgtttttag tgagttagat gaagcaagac aaaaactttt agtaaataat ttaagcaatg
   142201 ttcaaatgtt tataacaagt gctgaagttt cacataaaaa aatatttgat gaaaaaaatg
   142261 ttacaatatt taatattgaa aatggcgatg ttattagcat agagaatgga ggaaattaaa
   142321 tgaaacaaga atacggtgca agtcagatac aagtattaga gggattagaa gccgttagaa
   142381 aaagaccagg tatgtatatt ggtagtacaa gccctagagg tttacatcac ttagtttatg
   142441 aagttgtaga taatagtata gatgaggctt tacaaggata ttgttcagac atatatgtat
   142501 ctattaatga agatggcagt gttttagtaa aagataacgg aagaggtata cctgttgaaa
   142561 tacatcctaa aactggtaaa tcaactttag aaacagtatt aactaatctt catgcaggag
   142621 gaaagtttgg aggcggagga tataaagtat ctggaggtct tcatggagtt ggtgtttctg
   142681 tagttaatgc attgtcaaaa tggatggtag cagaggttta tttaaacgga aagatatata
   142741 agcagacata tgagaaagga ttgccaacat ctaagcttga agtagttgga gaatctcaag
   142801 ataaaggaac aatgattcaa tttatgccag atgagacaat atttgatgaa atagagttta
   142861 aatatgaaac attggagtat aggcttagag aactttcttt cttgaataaa ggaataaaaa
   142921 tagtatttga agataaaaga gaaggacaag aaaaaagaaa agaatttcac tatacaggtg
   142981 gtttggtaga atatattaag tatttaaata aatctagaac tggtatacat gatgacatag
   143041 tttatataga taaaaaggtt gatgattgtt ttgttgaact agctatgcaa tatacagatg
   143101 gttatacaga gaacatatat tcttttgcaa acaatataaa tacacatgaa ggtggttctc
   143161 atttaagtgg atttaaagca gctcttacta aaactgtaaa tgattatgct aagagaaata
   143221 aatttttaaa ggaaaatgat gttaacctac ttggtgaaga cataagagaa ggtcttacag
   143281 cagtagtatc agttaaatta ccagaacctc aatttgaagg tcaaactaaa acaaagctag
   143341 gtaatagctt tatgagaggt atagttgata gtgtaacagt tgatgaactg gggtctttcc
   143401 tagaagaaaa cccatcaaca gcaagaatca tagttgataa agctttaaga gcacaaagag
   143461 ctagagaagc tgcaaaaaaa gcaagagaat taacaaggag aaaaagtgta ttagaaagta
   143521 catctttacc tggaaaactt gcagattgtg cagaaaaaga tccatctaaa agtgaaatat
   143581 tcttagtcga aggggattca gcgggaggtt cagctaaaca aggtagagat agaaatagtc
   143641 aagctatact tccattaaga gggaaaatac ttaatgttga gaaatcaaga ctagatagga
   143701 tactatcttc agatgaaata aaaaatatga taacagctta tggttgtggt attggagaag
   143761 attttgatat agataaggct aggtatcata aaattataat tatgaccgat gctgatgtag
   143821 acggagccca tataagaact ttattattaa cattcttctt tagatatatg agacctctta
   143881 tagatgaggg gtatgtttat gcagcacagc cacctttata taaagtgaca aagcaaaaga
   143941 aggaacatta tgtttactca gataaagagt taaatatctt actagatgaa attggaagaa
   144001 atggtgttga acttcaaagg tacaaaggtc ttggagagat gaatgcagag caattatggg
   144061 aaacaactat gaatcctgag acaagaactt tattacaagt tactgtagaa gatgctgcaa
   144121 ttgcagatga agtattttca atgcttatgg gtgataaggt tgctccaaga aaagaattta
   144181 tagaagaaaa tgcaagattt gttagaaact tagatatata gagagagggg attagtatac
   144241 atggaagaaa ataacaaaat actccctatt gaaatagcgg aagaaatgaa aaaatcgtat
   144301 attgattatt caatgagtgt tatagctgga cgtgctcttc ctgatgttag agatggttta
   144361 aagccagttc atagaagaat attatattca atgagtgagt taaatttaac tccagataaa
   144421 ccatacagga agtcagctcg tattgttggg gacgttttag gtaagtacca tcctcatgga
   144481 gatactgctg tttattatgc tatggtaaga atggcacaag atttttcaac tagagcactt
   144541 ttagtagatg gtcatggtaa ctttggttct gttgatgggg attcaccagc tgctatgcgt
   144601 tatacagaag ctaaaatgag taaattatca ttagaactac tgagagatat tgaaaaggaa
   144661 actgtagact ttaaaccaaa ctttgatgag tcgttaaaag agccttcagt attgccagct
   144721 agatatccta atttattagt aaatggctca aatggtatag ctgttggtat ggcaacttca
   144781 atacctccac ataatttagc agaagtaatt gatgcaactg tatatttgat agataatcca
   144841 gagtgtagtg tagatgattt aataaaattt gttcaaggac cagatttccc tacagctgca
   144901 attataatgg gaaaagaaag tatagcagaa gcatacagaa ctggaagagg aaaagttaaa
   144961 gttaggtcta gagcttttat agaagagcta ccaaaaggaa aacagcaaat aatagttaca
   145021 gaaatacctt atcaagtaaa taaggctaaa ctggttgaaa gaatagcaga gttagttaaa
   145081 gaaaagagaa tagaaggtat atcagaccta agagacgaaa gtaatagaaa tggtatgaga
   145141 attgttatag aattaaagag ggatgctaat gctaatatag tattaaataa tttgtataaa
   145201 cattctcaaa tggaagatac ttttagtata ataatgcttg cacttgtaga tggtcagcca
   145261 agagttttaa atcttaaaca aatattatat cattatatta aacatcaaga agatgttgtt
   145321 acaagaagaa ctaaatttga actaaataaa gctgaagcaa gagcacatat tttagaagga
   145381 ttaaagattg ctttagataa tatagatgct gttataagct tgataagagc ttcaaagact
   145441 gggcaagaag ctaagctagg tttaatagaa aaattcaaat taactgaaat ccaagcacaa
   145501 gctatattag atatgagact tcaaagactt acaggtttag aaagagataa gatagaagct
   145561 gaatatgaag atttaatcaa gaagataaat agattaaaag agattttagc tgatgaaaga
   145621 ttacttttaa atgtaataaa ggatgaaatt acaataataa aagaaaatta ctctgatgag
   145681 agaagaacag aaataagaca tgctgaaggc gaaatagata tgagagatct tataagtgat
   145741 gaagaaatag caataactct tactcacttt ggatatataa aaaggcttcc atctgatact
   145801 tataagagtc aaaaaagggg tggaagaggt atttcagcac ttacaactag agaagaagat
   145861 tttgtaaggc acttggtaac tacaactact catagtagac tattattctt tacaaataaa
   145921 ggtagagtat ttaaattaaa tgcatatgaa ataccagaag gtaagagaca ggctaaaggt
   145981 actgctatag tgaatttact tcaattgtca gcagatgaga aaattgctac tctaatacct
   146041 attgatggta atgatgaaaa tgaatattta ttacttgcaa cgaaaaaagg tattgttaaa
   146101 aagactaaga gagaagagtt caaaaatata aataaatctg gtcttattgc aataggttta
   146161 agagatgatg atgagcttat tggagtagaa cttacagatg gaaaacaaga agtactttta
   146221 gtaactaaag aaggtatgtc tataagattt gatgaaaatg atataagata tatgggtaga
   146281 acagcaatgg gtgtaaaagg tataacttta agtaaagaag attttgttgt gtctatgaac
   146341 ctttgcagta aaggtacaga tgtgttagtt gtaagtaaga atggttttgg aaagagaaca
   146401 aatatagaag agtatagaag tcaaataaga gctggtaaag gaattaaaac ttataatata
   146461 tctgaaaaaa ctggtacaat tgtaggtgca gatatggtca acgaagatga tgagataatg
   146521 attataaatt ctgatggagt tcttattaga ataagagtca atgaaatatc actgtttgga
   146581 agagttacaa gtggtgttaa attaatgaag acgaatgatg aagtcaatgt agtttcgatt
   146641 gccaaaataa atattgaaga agaataggat aaatatccta ttctttttgt ataatgtagt
   146701 tagataaaaa tttaaaattg aaaggagtaa ttgttatgtg caataaaaga agttgtaaaa
   146761 aaggtggatt tttattatta ggagctattt tagggtttat atttggtatg ttttttgcac
   146821 ctaaaaaagg ttctgaacta agaaaagaaa caaaagagaa gtttaatgat gtcaaagaaa
   146881 atccaaaaga agttctacat gaaacattta atgatgttaa agagagaata ataaatttag
   146941 tggatgatga taataatgaa gaagatataa agatttcaga agaagatata gtaataagta
   147001 aaagctttga tgatgaggga gatgttaact aatgaatgca tgggggtggc aaattggagc
   147061 agtgttagta ggaagctctg ctcttatagt agcaatttat ttagctaaaa ctctaaacag
   147121 cataaataag gttgttgaaa aggcatataa gattgtagat tataatgaaa gacatataca
   147181 agatattgtt gaaaatgcat catcaatatc aaagggaata gatgatatag tttatgtaat
   147241 taataaaata ttgagtatag gaaatatatt taaaattatt aaaaggaaat aggaggtttt
   147301 tacatgtcta tgaatattga ttcaaattta gattcacaaa ataaattttg gaatgtttgt
   147361 cttgatggag aacttgatgt ttctacagca gataaactaa aggaacattt acatgcttta
   147421 atagaaaaaa atatgttaga tgtaaagatt aatcttaaag atttagatta tatagactca
   147481 acaggcttag gagctatgat aggtgtatta aaaaaattaa aaataaatga aaaagagata
   147541 tacatagtaa atcctaagag taacgtaaga aagattttta ctataacagg tctagataaa
   147601 atatttaaag tggagggata aactttggct tgtgagacta taaagatgga aattactaca
   147661 aatccagatt atgttagtat aataagatta acagcatctg gaattgccaa taagatgggt
   147721 tttccaatag atgatataga agatataaag gtagcagtat ctgaagcatg tacaaatgca
   147781 ataaaacaca gtaaagatga tgtgtttaat atagtattta atattttaga taatgcaatt
   147841 aatatagaaa ttcaagataa tggaaaagga tatgatgtta gctcaataag tacaccagat
   147901 ttagagaatc caaaagagag tggtcttgga ttgtttataa ttaaaacttt aatggatgat
   147961 gtagatattg aatcagaaca taatcaaggg acaaaaataa aaatgactaa atatttagga
   148021 gttgatattt aatgaaaaat gtagctaatg ctacacatta cctaaatatg gatacaaaag
   148081 agctatttaa tttatataat aaaaataaaa atgtagacat tagaaatatt cttattgaaa
   148141 gacatctgta tttagcaaga ttgttagcta agaagtatat aaacaaaggt gttgattttg
   148201 aagatatata tcaagttgct tcattggcat taatttatgc tattgataga tatgatgttg
   148261 agaaaggatt tgagttctcc agctttgcaa caccaactat agtaggagaa ataaaaaagt
   148321 attttagaga taaggtatgg acacttagag tcccaagaag aatacaggaa ttaagcaaaa
   148381 agataagtga tgcgaagatt aaattagaac aagaaaataa gaagcatcca aaggtaaaag
   148441 atatagctga ttatataggc gttagtgaag aagatgtttt agaggctatg gaggcttctt
   148501 atggatatca accaatgtct ttggattcat caagtaatga tgattcagag gataaagata
   148561 taactcttat tgataagatt ggaaaagaag aaggtaactt tggaagtata gagtatgaag
   148621 attttattaa taagtttatt gaaactttaa atgaattaga agttaaaatt tttaaagata
   148681 gatttttctt tgataaaaca caatctagta tagctaaaga actagggata tcacagatga
   148741 ctgtttctag actagagaaa aaggtagtag agaagctgaa aaaagaatat gaaaaaaatt
   148801 tataaaaaaa tataaaaaaa gtattgacct actgttttaa agatggtata gtattacttg
   148861 tccttgaaaa aaggaa
//
LOCUS       DAEHWM010000002        86089 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.002, whole genome shotgun sequence.
ACCESSION   DAEHWM010000002 DAEHWM010000000
VERSION     DAEHWM010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 86089)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 86089)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..86089
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.002"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            54..521
                     /locus_tag="KNP36_000150"
     CDS             54..521
                     /locus_tag="KNP36_000150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HBF0872049.1"
                     /translation="MKFLNVLVVVEDIEKSKKFYYDVLGLKVICDFGENVVLEGNISL
                     QEKKLWLEFINKSDSEVKFNGNDAELYFEEDNFDTFVERLSTMKDIDYVHLAIEHRWG
                     QRAIRFYDLDGHIIEVGETMSSVCRRFLDSGLSIDEVAKRMDVTVEYIESVLE"
     gene            1652..2314
                     /locus_tag="KNP36_000151"
     CDS             1652..2314
                     /locus_tag="KNP36_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872050.1"
                     /translation="MSILEIKNLNKIYGKSETEVKALSQINLKINSGEFVVIVGKSGS
                     GKSTLLHIMAGLETPTNGDVIIDNINISSLDEKKRSALRKEKLGLIFQSYNLIPVLTV
                     EENIKLPTINIKNKDEAYINELMELLGIKDRRMYLPNQLSGGQQQRVAIARALVNKPS
                     IVFADEPTGNLDTKTESDVLSLLKESQKKYNQTIIMITHNIDITKYADRVIEIEDGFI
                     RE"
     gene            2323..4830
                     /locus_tag="KNP36_000152"
     CDS             2323..4830
                     /locus_tag="KNP36_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872051.1"
                     /translation="MKLNYIVKKYIMGNKKNTLLIIVSIVISTALFLIMNIISEDATN
                     LMINQAKNEFTLKHAQYINPKDEEIKYIENNTSIDKVGKSMLLGISDIGKGQTLQILS
                     QDKVAEELNDIYTLEKGKLPVAENEIAIDSWYIKQKKIKNPIGKRITLDYRRQGIDQE
                     DLYTGEKEFKITGILNSNPILKAQGTSIGLISNDCAIKNIPTKNKYDQVMFTFKKEKN
                     IQRQSQKLIKNGNLNENNIYFNNELLIAISDSMNLKIPYIIVNIVLALATILLIYNIF
                     YILVSNRIKDFGIFRALGFNPNDIFKIMILEVSIYSIISISIGLILGGIIASLSREYV
                     IGVIYNVNYINSIKNQNYINTYIISILLSLGTIIISVSKPLMLSVKTDPMICIRRNNE
                     KVDIKQNSFINKFMIKLFKDYGNIASKNIQRNKKRTNLSIASMVIIFFLMATIYTKST
                     SNFLSDGVLKYWIQGDYLLHNIDISTIRSNNKGYDKNVLQEIKAIDGVTKVNSYRHKW
                     FNIKIDDKSINKNSDYWKKNKDNIEARSEVKDGIKVYNNSFEFLGIEDTDILEDFLIN
                     GKENIDKFSKQPYLYITKKSSDSLNIKKGDRIKVYFDIIDSKTNNFTKTISQEFIVCG
                     IITTLPVTSQVGAEFGGVISTNQFNKFTGISSYERFDIWTSKLANDKYVESELNKITE
                     KTNKGILIPYKAETAEYEKIDNQKTLIMVLVTGIIVILSLFNCCNTIVTSINSRSREF
                     ALFRGIGISKHEINKIVKLESYIYIIVSFCISIIPILIVRSIIIKPFESINLINWKFI
                     GAIILIVFILVSIIMITTLKTLNKIQNENFMEEIKTL"
     gene            5161..5505
                     /locus_tag="KNP36_000153"
     CDS             5161..5505
                     /locus_tag="KNP36_000153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872052.1"
                     /translation="MYCLSVVLAIYGIYVFINCTEYIYTMLSTKHLTVKGNEYTIINY
                     YMSNFSQYIIFAILLASMGFVIQKIVHMHFSEIELSGNYSTTVRNISDISLDNDNEMF
                     NRGNIENSILKK"
     gene            5743..6429
                     /locus_tag="KNP36_000154"
     CDS             5743..6429
                     /locus_tag="KNP36_000154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872053.1"
                     /translation="MSSILLVEDDLSLIYGLEYSIQKNGFSVDVARTVEEALQIYKEK
                     NYDLLLLDVSLPDGDGFDICKRVREASNVPIIFLTASDEEVNVVMGLDMGGDDYITKP
                     FKLNELISRIKALLRRYNFTSENVTELKSNNITVKLLENRVFKNEIELELTTAEYKLL
                     CLLMKNKNIVLTRKNILDKLWDGNGSFVDDNTLSVYVRRLRNKIEDNPENPKNLLTVR
                     RMGYKWNVIK"
     gene            6440..7681
                     /locus_tag="KNP36_000155"
     CDS             6440..7681
                     /locus_tag="KNP36_000155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872054.1"
                     /translation="MKVFSNKDIKIFFLVIISVLLMFIVVGQIVVINITNDYKSALLE
                     HDYNIAGYLNSMGVDKSKIPAVFTTNEDKYTLKGKEILNTARYDFGTDDSFMPSVKLF
                     QGKYIKTMFLYLFVFFTMIIFILYVYFFRQQNKIEEASYKIDSFMNGNINVRLNTYEE
                     GSLSKLFGSIDAMSTSLNTHILKEKQNKEFLKNTISDISHQLKTPLTALMMYNQILQE
                     ESHNSEIVENFVQKSQNELERIESLIQNLLKITKIDSKTIILNKASVNVKKLITKILY
                     SFETRAEKEGKSISIRGLENTNLFCDYEWISEALSNLIKNALDNTKENDKIMIEWVET
                     PITTIISVSDTGNGIHIEDIHHIFKRFYRSKFSKSNQGLGLGLPLVKSIIEQHNGTIT
                     VESNFLQGSTFTLSFLKLTNM"
     gene            7752..8435
                     /locus_tag="KNP36_000156"
     CDS             7752..8435
                     /locus_tag="KNP36_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872055.1"
                     /translation="MDILVVNNLCKTYGNGYTKVEALKDVSFTVSKGEFVTVVGESGS
                     GKSTLLNLLGGLDTPTSGKIFVDGKEICSMKEEKQTIFRRRNIGFIFQSYNLIPELTV
                     EQNIIFPLLLDYKKPDTIYLDEVLTILGLKDRKSHLPNQLSGGQQQRVAIGRALITKP
                     SIILADEPTGNLDSKNSSDVISLLKVTAEKYNQTIIMITHNTNIASTADRILQVSDGM
                     LKDLGVNRE"
     gene            8432..10765
                     /locus_tag="KNP36_000157"
     CDS             8432..10765
                     /locus_tag="KNP36_000157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0872056.1"
                     /translation="MRSYLELVPQYAKVHKKKNRTTILCIVIAVCLVTAIFGLADMAI
                     QCQKVQFIKDDGNWHIVLKNLNEEAISEISSRVDIAHYGRGQVIDNGEFKSKEILIQG
                     LDEDLAKQLGLEIIKGRYPVVENETLIDVDAVKSFNLKVGDFIKIKLADGRNKNYKIV
                     GEYSSLSRLRASDKHGLMLSILGTQAIKKSETYDYYYITFKDKVNIRKATSDIKNTFN
                     LSDKQIGKNEKLLSIIGQGDSDYSKPLYLTAGGLFILVLIASIIMIYNSFNMGVIERI
                     KFFGLLRCLGASKLQVKKFVVLESLILSVKAIPLGLLLGCIVTIISSIFLKYVNTELF
                     GSMPILKVSFIGIVFGIIVGFLTVILSAIVPAKKASGVSPLSAIRGNLMFKEILTSGK
                     ASKIANAGSSKIDVSMGINHAFSRKKSFILMTSSFAISIVLFLGFSVFIDFMYQALKP
                     IKPEAAHISIVDADFKSVLTKDDINEISNIKGIKKVYSRMMTDVEATYNNKEATSQLI
                     SYEKNQFDWAKKYLVKGEINEDKLESENIGLVEEGHGFNIGDKIYIKNGNSKKEIEVA
                     GILSSISFDVKDKYIGNIITSENTFTSITDIKDYIIIDTQVDEDAPEDLIQNIRNVLD
                     DNLEVRDKRQGNLEAKNSFYTMAVFVYGFVFIIAIISMFNIINSMNISVTSRINYYGI
                     MRAIGMSNKQLRKMVIVESSTYAVSGCLLGSVLGLILHRYIFVSLVTLKFHIDWQIPF
                     DLLFIIVVTMIIITLLAVRKPIKKICELDIIEVVNAQ"
     gene            complement(10873..11435)
                     /locus_tag="KNP36_000158"
                     /pseudo
     CDS             complement(10873..11435)
                     /locus_tag="KNP36_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901678.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(11549..12898)
                     /locus_tag="KNP36_000159"
     CDS             complement(11549..12898)
                     /locus_tag="KNP36_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0872057.1"
                     /translation="MEKAKKLGLFSMILLGINSIIGSGIFLLPGKVYNLAGQNSMFIY
                     IFATLLVLSILLCFAEVGSMFDKNGGAYLYSKKAFGDFIGFEVGTMSWVIRIISWSTL
                     AVGFATALGSFWPESATEYKGYIAAILVTLLSINSLFGIKSTKIMNNVITIAKLVPLI
                     VFIIVGIFFIKFVNIVPSGNVVNSSMGPAIILVFYAFTGFESFIVASGEMENPKKNLP
                     VALITTIFICAIIYILIQIVCMGILGDRLFENSIPIADASSVFLGNYGKFFISVATLI
                     SIFGINIGSSIVTPKCGSSLAEEGSLPAFIGKTNKYGAPYVAIIISLICCIPLVLTGS
                     FEQLAVMSVIARFAQYIPTCLSVIVLRKRTDVKASFKIPFGPVIPMVAILGSLWLLQQ
                     AWAEDISKPITQNRVLIGLGAMLLIAPLYIFMKKNKEIEHKNKSEDSKLYISREKIQ"
     gene            complement(12935..14155)
                     /locus_tag="KNP36_000160"
     CDS             complement(12935..14155)
                     /locus_tag="KNP36_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0872058.1"
                     /translation="MQQALKLKYQTKELGKDFVIESCNSIKPWLINIRRELHKIPELA
                     LEENLTKQKVISYLKEIGIDYMEFTKHNGIMAYILKESADKTICIRADMDALPIEEEN
                     NIPYKSIHSGKMHACGHDAHTTMLLGACKVLHSIKDKLNVNVKFLFQPAEEGFGGAKF
                     LVEDGCLENPKVDYIFGLHVMPHIETGFIEIKYDTLNASVDTIKISIKGKRAHGAYPE
                     NGIDAIVTASQIVTSLQTIISRNLEPNNAAVLTIGKIYGGDAHNVICEDVKLEGTLRT
                     LNSKTRNFMIDKIAKIVGDTASAFGCVGTLHVSDENYPAVINEKELVDTVISNTKELL
                     GEEKFILRPNPSLGGEDFSFYTEHCKGAFFHLGCKNEEKGLISPLHTSSFNIDEDCLP
                     IGVMMHVMNTLYFN"
     gene            complement(14524..16536)
                     /locus_tag="KNP36_000161"
     CDS             complement(14524..16536)
                     /locus_tag="KNP36_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872059.1"
                     /translation="MKKSVALVNDSRKDLIDFLENNLKLVFGDSININRYFINEINDN
                     DIINDDVILVMSVERLDKIINNILDKKKVIVVRRTFREDKIYNLLSLPQGTNVLIVND
                     SDETTLETISLFYKIGVTNIRPIPYMNDNNYKNIKIAITPGVPEKVPSFISDIFDLGH
                     RYIDISTFIEIINLLQIDSKEIQSNLVKYSEEIISLDTGIKDKYKELFLKIEELDTIL
                     NLSKDGILFTSKDGEINTYNSKVKDILDINEDIYGKYIEDIFVDSLKVLLSEKEILDK
                     VVVFNKKYINVNKKNIYNRDEKMGTYYSLQEITYIKKLEQNLTKKLREKGQIAKYTFK
                     DIKTNSPKMFECIDLAKKVSKSDLSILIRGESGTGKELIAQSIHNNSNRKNQPFIAVN
                     CAAVPENLLESQLFGYDKGTFTGGLKDGKQGLFELANNGTIFLDEIGDMPLELQTKLL
                     RVLQEKQIMPVGSHNVINIDVRIISATNKNLEQMIDNSQFREDLYYRLNTIPINIPPL
                     RERKEDILIIMEDLINKKLVITPEAKKLIQNYMWKGNIRELQNVTSYLNIMCEDIVLE
                     KDLPPNLRSSDNKNTSLKLKYSKNDILNILEILILNKESDVGIGRGLILKALLDKNLQ
                     ITEGKIKKIFEYLKKEELIICSSGRYGSKITQKGEDFYNKLKYKGL"
     gene            17007..17657
                     /locus_tag="KNP36_000162"
     CDS             17007..17657
                     /locus_tag="KNP36_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic nucleotide-binding domain-containing
                     protein"
                     /protein_id="HBF0872060.1"
                     /translation="MKAEKTSIYPIIKNNLNKISIVEYKKGQRFVASDKDLQEVFFII
                     EGVALVECTTRGGNKFLVDIVPENEFIGKISYIYEHNLKCDIFAKTNIKLFRFEKNVF
                     EEFYLKPDFIALFHRKCTRRIYELYKTRMVRELFSCTEVIAYCISNKQENNVCNIKAI
                     RNFSEIYSISRKSRYHSLLKLTEKEIVKKMGNTYEILNYDELHKLAFEVKEFLEDE"
     gene            complement(17797..19173)
                     /locus_tag="KNP36_000163"
     CDS             complement(17797..19173)
                     /locus_tag="KNP36_000163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0872061.1"
                     /translation="MQELFSLKDENKRFYKILLSLCIPIIIQNLISTSVNVIDTIMIS
                     SLGETSVASVGVANQFFFLFNMSLSGITGGAGVFISQFYGKKDVSNIRKVTGLTCVLA
                     IVLSFVFVIPALLTPKPIIHIFSYDSEVVKLCIDYFSIAVFSYPLIAVSTVFSTGSRG
                     VRNPKLGMICSAFALVTNVILNYGFIFGNFGLPALGVKGAALATVIARICELILMITY
                     VYLYKKDYILKFGLKNLKAIDKIFIKSFSSKSFPIFVNDSVWAIGTVLYSVAYARAGT
                     SAIAASQIATSTGNFFIMTAVCIASGASIMLGNELGADHIKRAIEYAKKFSILVFSAG
                     LILGIILILNIPLLLKMFSVSDSLASDITKIFFIMGILMALKSFNTLVIIGILRSGGD
                     TKYALFLELGCMWLASIPLTFIAAFKGAPIFVLVLLTYSEEVVKFIFGVPRALSKKWA
                     INIVKEID"
     gene            complement(19189..21102)
                     /locus_tag="KNP36_000164"
     CDS             complement(19189..21102)
                     /locus_tag="KNP36_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBF0872062.1"
                     /translation="MIVLSCNNLNKSFGIDSILENISFTVNEGDKIGIIGVNGTGKTT
                     LFKIISGIYGYDSGDIYTSKDCEIGYLEQNTNFYSDNTILEEVLEVFKNLIEMESYLR
                     ELEVKISEESTKTNSPIIEKIMDEYSHKLELFSDLNGYGYKSEAKGVLKGLGFSDNDM
                     DKPISILSGGEKTRVLLGKLLLKKPTLLLLDEPTNHLDSEAIEWLEVFLKQYKGTVML
                     ISHDRYFLDQSVNRIFEVHNKKLKVYNGNYSKFVELSKIEKELELKKFEDQQKEIKKQ
                     EESIERLKAYGREKHLKRARSKEKALDKVDVLDKPEAYRKKARIQFTPSVQSGNDVLQ
                     IRDVSMGYGERILFKDLDLDIYRGEKVALIGANGVGKSTLFKIITNELQPLSGNIKFG
                     TNVHVSYFHQEQKTLNLDNTIIDEIWENNTHLTQTTLRNMLGAFLFVDEEVFKKISTL
                     SGGERARVAILKLILSNANLLLLDEPTNHLDIDSKEVLEEALTNYDGTIFTISHDRYF
                     LNTVVDKILVLDENGITEYLGNYDYYIDKKRQIQEMSIIEEKEEKTRTQIKDEKRKER
                     EQREIEKKNRIKRQNIEKEIEKLEIEIEKLDILLCQEEVYSNPDKAKEVSQEKINLEN
                     NLASLYDEWEEFM"
     gene            21238..21870
                     /locus_tag="KNP36_000165"
     CDS             21238..21870
                     /locus_tag="KNP36_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HBF0872063.1"
                     /translation="MLGNKNISMAVIRRLPKYHRYLGDLLDRDIQRISSKELSDIIGF
                     TASQIRQDLNNFGGFGQQGYGYNVEALHTEIGKILGLDRPYNAVLVGAGNLGQAIANY
                     AGFRKAGFEIKALFDANPRMIGLKIREFEVLDSDTLEDFIKNNNIDIAVLCIPKNGAQ
                     EVINRVVKAGIKGVWNFAPLDLEVPKGVIVENVNLTESLFTLSYLMKEGK"
     gene            22009..22548
                     /locus_tag="KNP36_000166"
     CDS             22009..22548
                     /locus_tag="KNP36_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="HBF0872064.1"
                     /translation="MVFVEELWKKAIEFHGHECPGLAIGFKAALAAREYLGCKQSGDE
                     EIVCISENDACGIDGIQVVLSCTMGKGNLLLRMTGKSVYHFFNRENGKSIRIYVKSKP
                     FQMDREGYKKYLLESDFEEIFEITDTKLRLPEKARIFKSLKCEVCGEFASEQYIRIEE
                     GKKVCLDCFNKYERFYEEY"
     gene            complement(22724..22894)
                     /locus_tag="KNP36_000167"
     CDS             complement(22724..22894)
                     /locus_tag="KNP36_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004619190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0872065.1"
                     /translation="MAYKITDACISCGACEAECPVSCISAGDDAYVIDAGSCIDCGSC
                     AGACPVDAPQPE"
     gene            23179..24246
                     /locus_tag="KNP36_000168"
     CDS             23179..24246
                     /locus_tag="KNP36_000168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HBF0872066.1"
                     /translation="MKNKLVYICIMSLLLFVVGCSNNPNKESTIKKDSKNNQSQVKEE
                     KREPVKKDITISFAGDVTMGNYKGSSYYGSFDHEFKRQGEDYNYFLKNVKPVFEKDDL
                     TVVNLEGPLTTASNAKEKKFAFKGKPGYVNILKSGSVEAVSIANNHSEDYFEEGMKDT
                     QFILDENKINYFGLGKDAVVDVKGIKVGLLGYNGLSTEYNEKNLKQMEDDIKSLKKKS
                     DVVVVYFHWGIELDYYPDKKQKDFAHYAIDKGADLVMGSHPHVIQGIEKYKNKYIAYS
                     LGNFCFGGNKNPSDTDSYIYQQTFTFSDNKLTSIKEPNIIPTSITSSNSRNNYQPKIL
                     DGSEKDRVLNKLEKISKDLNK"
     gene            24416..26317
                     /gene="cooS"
                     /locus_tag="KNP36_000169"
     CDS             24416..26317
                     /gene="cooS"
                     /locus_tag="KNP36_000169"
                     /EC_number="1.2.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic carbon-monoxide dehydrogenase
                     catalytic subunit"
                     /protein_id="HBF0872067.1"
                     /translation="MACNTCKMCESADKKLESFVASKDVETAFHRTEDQKVKCGFGLQ
                     GVCCRLCSNGPCRVTPKSPRGICGADADTIVARNFLRAVASGAACYLHVVENTAKNLK
                     NVGITKGVVKGEKTLNQLAEMFGIESDEKYDKCIKVADKVINDLYKSRDDKMELVEKI
                     AYAPRVKKWKELGIMPGGAKSEVFDAIVKSSTNLNSDPVDMLVNCLNLGISTGLYGLT
                     LTNLLNDVMLGEPVIRMAPVGFNVIDPDYINIMITGHQHSTFANFQDRLKDEDVIKLA
                     QSVGAKGFKLVGCTCVGQDLQLRGEHYQEVFAGHAGNNFTSEAVLSTGAIDIVLSEFN
                     CTIPGLEPIADKYKVKMVCLDDVAKKANAEYIGLDRSKLDELSNTLIEKALESYKERR
                     GSIEIDIPKDHGFEQSLTGVSEKNLKAFLGDSWKPLINLIAEGKIKGVAAVVGCSNMT
                     AGGHDVNTVELTKELIKKDIIVLSAGCSTGGLENVGLMSPGAEELAGENLKEVCKTLG
                     IPPVLNFGPCLAIGRLEIVATELAAELGIDLPQLPLVLSAPQWLEEQALADGAFGLAL
                     GLPLHLALPPFITGGKLVTEVLTEKLKDLTGGHVIVNPDPKSSANQLEEIIIDRRKNL
                     GLKDVECNA"
     gene            26310..26783
                     /locus_tag="KNP36_000170"
     CDS             26310..26783
                     /locus_tag="KNP36_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBF0872068.1"
                     /translation="MHRIFINKDLCTGCKSCVLACMLKHNKDYDMYTLDLENIDNDSR
                     GHIELDSKHNNPVPILCRHCDEPECVLACMSGAMHKDSESGIVSYDEEKCGSCYMCVM
                     SCPYGLLKPDDRSKQNILKCDLCKDEEYPRCVANCPSGAIELQKEENDELCSVRG"
     gene            26758..27984
                     /locus_tag="KNP36_000171"
     CDS             26758..27984
                     /locus_tag="KNP36_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBF0872069.1"
                     /translation="MNYVVLGASAAGINAVKTLRELDKDSNIVVISKDENVYSRCMLH
                     HVISEHRILKQINFVDEDFMEQNNVKWIAGKTVKGIDINKKVVQTEDITVNYDKLLIA
                     TGASSAIPPIKNLRDGNFVYSVRNIDDIYKIKEKAQNSKNVVIIGAGLVGIDALVGLF
                     KYEQLNISVAFMEKYILDRQLDEYTASVYENKFKEKGVKFYPSASIQEIVLDNSKNVT
                     GVAFSNGEVLDADMVIVATGVKPNADFLDGTGIEYDRGIIIDDMCQTTQKDIYAAGDV
                     VGKNAIWPLAVKQGIVAAYNMVGKDKKIEDEFAFKNSMNFMDIPTISIGMNTPVDDSY
                     KVLTRHGINDYKKFVFKDNVIYGAVIQGDISYVGVLTYLIKNKVEIYDLENRIFDICY
                     ADFFNIKENGEFCYSV"
     gene            complement(28123..29310)
                     /locus_tag="KNP36_000172"
     CDS             complement(28123..29310)
                     /locus_tag="KNP36_000172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBF0872070.1"
                     /translation="MNITKNFLKDYLEKFGETPFLVRLKDEEEFLIGEGSPQFKVIVN
                     NDISKSELLKSTSLALGEAYINRDIEVEGDLFLTLNLLLKQIDKFNIDNSAVKHLLHS
                     SNSMRHQKKEIHAHYDIGNDFYSLWLDKTLSYSCAYFRNDNDTLYDAQVNKVHHILTK
                     LNLEEGMSLLDIGCGWGFLLIEAAKKYKIHGVGITLSEEQFKEFNARIKEENLQDYLE
                     VRLMDYRELKKSDLMFDRIVSVGMLEHVGRENYELFIKNVNAVLKDGGLFLLHYISGL
                     QESYGDPWIKKYIFPGGVIPSLREMIHICSDYKYHTIDVESLRLHYVKTLLYWQKNFS
                     ENLPKIKEMFDDKFIRMWDLYLCSCAAAFNTGIIDIHQILFTKGIKNDLPLTREYMYN
                     CSK"
     gene            29583..30407
                     /locus_tag="KNP36_000173"
     CDS             29583..30407
                     /locus_tag="KNP36_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872071.1"
                     /translation="MEVYALVGSSGTGKSFKALEFAYENDIEYIIDDGILIYKNKVLA
                     GISAKQANTTIEAVKRAIFYNLEHRQEVREAIKKENIRKILIIGTSKKMVNQIVERLS
                     IGRVCKFINIQDISTKYEIEIAKQARKEGNHVIPVPAVEIKSMASGLSINSLKRLFRK
                     GSNRNMVVLEKTIIRPTFSYIGKFYISADVIKQIIEYEVYNFGSIDRINKINIENCNN
                     FMNIFVSININDLETIKKIEDIQQTIKKSIEKMTLVNVQKIDINIHKIKKINFLQC"
     gene            30536..31801
                     /gene="gluD"
                     /locus_tag="KNP36_000174"
     CDS             30536..31801
                     /gene="gluD"
                     /locus_tag="KNP36_000174"
                     /EC_number="1.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-specific glutamate dehydrogenase"
                     /protein_id="HBF0872072.1"
                     /translation="MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSI
                     PVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIP
                     YGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVD
                     EYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQ
                     GIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLN
                     FPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVF
                     AERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIK
                     EEYNVTMREAAYMHSIKKVAEAMKLRGWY"
     gene            32014..32604
                     /locus_tag="KNP36_000175"
     CDS             32014..32604
                     /locus_tag="KNP36_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBF0872073.1"
                     /translation="MHFKSKDLNLKYLVLFLKIVYWFNPFIYIMEKYMDLDCELYCDE
                     RVLKNCTVQQKQEYALTIVNSMKRSTNFSNKFVAGLNKQSDIRKRVINMFSEKHKNGI
                     LRALIISLFSSITFFKFDSTSIIEENDFLERSRYTFEGRQEDMFVTIDFIYADVPIKL
                     RKEHEENCRVNGIVPKDSDSIEIIPRFYKDCMDLKK"
     gene            32935..34068
                     /locus_tag="KNP36_000176"
     CDS             32935..34068
                     /locus_tag="KNP36_000176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBF0872074.1"
                     /translation="MSNFILNGIFRTVIVSSLSILMILIFKKNVFKRFSKKFNYYIWM
                     IVVIKLFLPFTYYTFTINILRSKKHININNINLEGFNNVSTISNNIILYTWIITVVVY
                     LIYTIFKYIKLKNLINDLSYDVDDGEIVNLYKNILEEFNITKDIKLKYSYEVETPAFF
                     NSCVLLPPHEYKLKELDWIFRHELMHFKSRDLYLKYVILFLKTVYWFNPFIYIMDKHI
                     DLDCELYCDERVLKNRNSEEKKDYALTILNAMRKGSNTSNKFIAGLHKQSDIKKRVMN
                     MFNEKYKNGILMALTLCLLSSITFLKVNSTSIVNLNILPKGMEEKDVTNSAIVTMIEF
                     TYAEAPKSMREEHKINCEFLGLIPKDSDKIGVGIEYYDSLLND"
     gene            34984..36006
                     /locus_tag="KNP36_000177"
     CDS             34984..36006
                     /locus_tag="KNP36_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBF0872075.1"
                     /translation="MKKKILIPVFASVMALSVSSIVNADEVNDSSQNKDDKTNTELNL
                     GEYKEVKYKVAKIKDGVAIKIREEGQVQNIAYSGDEFTVLGTQGEWVKVKVEDGEGWL
                     ATRYVDISEGVGYTNADKVNLRKDKSESSEVIEELEKGSSLLVLEDNGDWLKVKDGET
                     EGYVKSSYISDKAPVIEEPQVNPSIDQNVDSTNNNQQNNANTNQQNNNSNVPTANSNA
                     VQAVLNLAYSKQGCPYVWGAEGPNTFDCSGFTQYVYRNAVGKNIPRTSKAQSKYGQTV
                     SKANLQPGDLVFFTTNGSGSVSHVGIYVGGGNMIHSPSTGKTVSVTSINSSYYTARFV
                     TAKRIL"
     gene            36302..37222
                     /gene="pyrB"
                     /locus_tag="KNP36_000178"
     CDS             36302..37222
                     /gene="pyrB"
                     /locus_tag="KNP36_000178"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase"
                     /protein_id="HBF0872076.1"
                     /translation="MLKSRNLIQPEDFSIEEIDEILELAQKIIDNPSKYSRICEGKLL
                     ATLFYEPSTRTRLSFESAMNRLGGRVVGFSEPNSSSASKGETLGDTMRIVSGYVDIIA
                     MRHPQSGAASEAARYTEVPFINAGDGKNQHPTQTLTDLLTIKSLKGTLESHTIGLCGD
                     LKYGRTVHSLVKAMARYKNTKFVFIAPEELKMPDYIKEAIKGHAYYETNNLDDVIGSL
                     DVLYMTRVQQERFEDKSEYERLKNYYILNKAKLEKASKDMLVMHPLPRVNEIDIDVDS
                     DDRAVYFKQAKYGMYVRMALIIKLLGINED"
     gene            37261..37953
                     /locus_tag="KNP36_000179"
     CDS             37261..37953
                     /locus_tag="KNP36_000179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HBF0872077.1"
                     /translation="MYKILENIYIGEDMYRMKVKGNFEGKMGQFYMLRAWDTYPVLSR
                     PISIHDIDEEGITFLYKVVGEGTQILSNLKVNDNIKLEGPYGNGYAKVDGKVALVGGG
                     IGVAPLYLVAKNIKNCDAYLGFREDVILEDEYKQVCNKVYTTVGNTFVTDIIDVEKYD
                     YILTCGPTPMMEKLVKMVEGTKTRIMVSLENHMACGVGACLVCTCKTNGGNKKTCKDG
                     PVFWGEDVIFNG"
     gene            37946..38848
                     /locus_tag="KNP36_000180"
     CDS             37946..38848
                     /locus_tag="KNP36_000180"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HBF0872078.1"
                     /translation="MGNLSVKFGSVEFKNPVIMASGTFGFGKEYNEIYDIQKLGGISS
                     KGLTLNKKPGNNGMRVHETSSGMMNSVGLENPGVQGFIDYELPFFSKLDLVRIANVGG
                     GTLEDYLLGVQMLNDKPIDIIELNISCPNVKAGGMAFGIKNEVAREVVREVRNITKLP
                     LVIKLSPNAEDIVGMAKVCEEEGADGVSLVNTFKAMAIDIKNRRPVFENVYAGLSGPA
                     IKPIALRMVHEVCKNVNIPVMGMGGITKATDAIEFIMAGATCIQVGTANFMNPRIGIE
                     IIDGINEFMDREGIKSLDEIRGII"
     gene            38933..39517
                     /locus_tag="KNP36_000181"
     CDS             38933..39517
                     /locus_tag="KNP36_000181"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HBF0872079.1"
                     /translation="MSKVDVVDILKKSDALLEGHFLLSSGKHSNRYVQCAKVLRFPEY
                     AAEVLSTVVEQIKDLDIDLVVGPAMGGVIVSYELGRQLGKEAVFTERKDNTMELRRGF
                     EVKKGAKIIIAEDVVTTGKSTMETKRVLEALGGEVVGVACIADRTNHDIGMPIYSAIK
                     LDIQVYESDECPLCKEGKLPVVKPGSREFKELGM"
     gene            39731..40657
                     /locus_tag="KNP36_000182"
     CDS             39731..40657
                     /locus_tag="KNP36_000182"
                     /EC_number="1.1.1.169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-dehydropantoate 2-reductase"
                     /protein_id="HBF0872080.1"
                     /translation="MKNQLNENHKKVVFFGVGAVGATFAEQFFNSKYDFKILCDNERK
                     KRYLEEGFIINGKRYDFDYVTKDEYKQEADFIIIGLKYNNLKENIKELDGLVGKNTVI
                     MSLLNGVDSEEIIGERFGIEKMVYSYVTNIDAKKINNNIIHTTNGIIVFGNKDNSEDR
                     KTNIITEVFDDVNIEYTLSKDIQRDMWWKYMVNIGVNQTSAILGAPYGVFQSSEHLRE
                     LAKSAMREVVAIAQAKDISLTEDDVEHSLHRILEHSKEGRTSMLQDVEAHRLTEVDMF
                     SKNICKLGKKYNIPTPINQTFFYMIKVIESRF"
     gene            complement(40709..41599)
                     /locus_tag="KNP36_000183"
     CDS             complement(40709..41599)
                     /locus_tag="KNP36_000183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0872081.1"
                     /translation="MFEELKTFVAVVEYKNFTKAGEYLNLSQPSVSKHIKNLENYFKV
                     VLINRSIKQKTIFITESGQILYKRAKEILNLLNITYHDVSQVSDAITGHLKIGASLTI
                     GEYILPNFLALFSKKYPDIDVEVFIKNTSIVSSHVKDYILDIGLIEGTCSSPSFIQEY
                     FFEDKMVLALPYKSHLLKDFSFDKLQNQKWIVREDGSGTRDYLDMFLSVKEIIPKSMM
                     VFGSNYAVKESVRNNLGITIVSNLVTSLPVLNNELSVIELGSSYNRHFSYIFPKDITL
                     SKAATIFIEELKIFSNLNSI"
     gene            41787..42818
                     /locus_tag="KNP36_000184"
     CDS             41787..42818
                     /locus_tag="KNP36_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sulfate exporter family transporter"
                     /protein_id="HBF0872082.1"
                     /translation="MLKKKSSLTLKTIREILPGLFVSVLVGYISIFISILIPKVGAAS
                     ISIFLGMFVGNLFLNQKVFQKGYKFSETDLLSYSIVLLGATLSVSTLIDLKVSGILFI
                     ILQMTITIIAALYIGKKLGFEENFRFLMASGNAVCGSSAIGATVPVVNATDKEKGIAV
                     TIVNVTGIFLMFLLPIISQFLYSHELVKTSAMIGGTLQSIGQVVASGAIVGENVKDLA
                     TIFKIVRVIFLVVVVLVFGHMKNQSNREILEEEKDEIKKKKVTIPWYVIGFFITCALF
                     SMNIIPKEVSVLCKEISNKLEIIALAAIGLKVNVKDLVKQGKEVSLYGLFVGIVQVVS
                     AVVLIKIFI"
     gene            43112..43987
                     /locus_tag="KNP36_000185"
     CDS             43112..43987
                     /locus_tag="KNP36_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA glycosylase"
                     /protein_id="HBF0872083.1"
                     /translation="MNVYEKGNGVILEGVTDFDPVHIFECGQCFRWHKQEDGSYTGVA
                     KGRILNVKKENDKIYLNNTNLKEFNSIWYNYFDLGTDYTEIKNKLKNMDEYLNKATEF
                     GWGIRILRQDGWEMLISFIISSNNRIPMIQRAIENLSRKFGKYIGEYEGNEYYAFPTP
                     EELNKASQEEIRACQTGFRDKYIKSTTQAVIENNDEVSEYTNLSTEDCRKELLKFNGV
                     GPKVCDCIALFGMQKYDSFPVDVWVKRVMQEFYIDEDMSLPKMRTYGIDKFKEMSGFA
                     QQYLFYYARELGIGK"
     gene            44005..45495
                     /gene="cls"
                     /locus_tag="KNP36_000186"
     CDS             44005..45495
                     /gene="cls"
                     /locus_tag="KNP36_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HBF0872084.1"
                     /translation="MGVIGTIFLFYLIISYLAGAIISVIILLENRDPAKTMSWLLMFI
                     IFPGVGLMIYAISGRNIRKRKLFKTQKLANNIKEKKLFDTLEKITEIVELEKESIKQN
                     KLLRDEEDGSYRKRVINMLLKTGMFPFTKNNKVDVFVDGNEKFKRLIEDIREAKDHIH
                     LEYFIIKDSEIGRVLKEELIKKAKEGIKIRILYDDVGCWRFWFNRKFFREMREVGIEI
                     AAFLPTKFPIIGGKLNYRNHRKIVVIDGIIGYTGGINIGDEYLGKNDKFGYWRDTHIR
                     IKGISVYMLQMTFLIDWYYTTKEVLVTKNYFPSVGNVGESMIQVVASGPDSDWEDIHY
                     AYFSAICQARKNVYIETPYFIPDESLLKAIKSAALSGVDVRIIFPKIADHKIVNIASY
                     SYFEEILRAGGKVYLYNKGFIHSKVVIIDDKIASAGTANMDLRSFMLNFEVNAFIYDE
                     EVIRVMTDDFFEDLSHCEELNLEVFKNRNIIQKIKESVARLFSPIL"
     gene            45688..45972
                     /locus_tag="KNP36_000187"
     CDS             45688..45972
                     /locus_tag="KNP36_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012062101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HBF0872085.1"
                     /translation="MKIRPLADRVVIKKVEAEEKTASGIVLPGAAKEQPQIAEVVEVG
                     PGGIVEGKEIKMELTVGDKVIFQKYSGTEVKIEGQEYTILRQSDVLAVIE"
     gene            46005..47633
                     /gene="groL"
                     /locus_tag="KNP36_000188"
     CDS             46005..47633
                     /gene="groL"
                     /locus_tag="KNP36_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729227.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HBF0872086.1"
                     /translation="MAKEIKFSEETRRALEAGVNKLADTVKVTLGPKGRNVILDKKFG
                     SPLITNDGVTIAKEIELEDRFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAIIREG
                     LKNVTAGANPILLRKGIQKAVTVAVEELKNQSRIVETQEAISQVASISAGDEEVGKLI
                     AEAMEIVGKDGVITVEESQTMNTELDAVEGMQFDRGFVSAYMVTDVDKMEAVLNDPYI
                     LITDKKISNIQELLPVLEQIVQQGKKLLIIAEDVEGEALSTLVVNKLRGTFDVVAVKA
                     PGFGDRRKEMLQDIAILTGAQVISEELGYDLKEADLSMLGRASSVKVTKESTTIVDGS
                     GDKKAIEDRVTQIKHQVEQTTSDFDREKLMERLAKLAGGVAVVKVGAATEVELKERKL
                     RIEDALNATRAAVEEGIVAGGGTAFVSVIPAIGTLIESLEGEVKLGAQIVKKALEEPL
                     RQIAINAGLEGAVIVQNVVNSEAETGFDALNEKYVNMIEAGIVDPTKVSRSALQNAAS
                     IASTFLTTESAVADLPEKEDAGMPGMGGGMPGMM"
     gene            47895..48635
                     /gene="larB"
                     /locus_tag="KNP36_000189"
     CDS             47895..48635
                     /gene="larB"
                     /locus_tag="KNP36_000189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel pincer cofactor biosynthesis protein
                     LarB"
                     /protein_id="HBF0872087.1"
                     /translation="MDLRKLLEEVKNENIDIDFALEKLKDLPYEDLGYANIDHHRELR
                     NGYPEVIYCEGKSDEHILGIIDKMNQKSSNILGTRCRKETFLKIKEIYNHAEYEEASK
                     ILKIQNHDIENIGKGKIVIATGGTSDIPVADEAYHTAKFLGNDVDRIYDVGVAGIHRL
                     LNKRHKIDSARVIVAVAGMEGALASVIGGLVDVPVIAVPTSVGYGANFGGLAALLAML
                     NSCASGISVVNIDNGFGAGYLASMINKL"
     gene            48719..49453
                     /gene="larC"
                     /locus_tag="KNP36_000190"
     CDS             48719..49453
                     /gene="larC"
                     /locus_tag="KNP36_000190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel pincer cofactor biosynthesis protein
                     LarC"
                     /protein_id="HBF0872088.1"
                     /translation="MSEKILYFDIISGISGDMTLASLLNLGVPKEIFLEEIHKLRMSD
                     EFNINISSKTENGIVGTKVEVITKEKHTHRNLVDIFEVIDKSTLNENVKSKAKKIFMV
                     IGEAEAKVHGTTIDKIHFHEVGAIDSIVDIVGASILVDLLCVDKVCASTVSVGSGFVK
                     CEHGIIPIPAPATIEILKGVPIKLNNVNGECTTPTGAAIIKVLCDEFVDELEFSPKQI
                     GYGIGHKKFEVPNILRTVLGEKKKKN"
     gene            49483..49902
                     /locus_tag="KNP36_000191"
     CDS             49483..49902
                     /locus_tag="KNP36_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF111 family protein"
                     /protein_id="HBF0872089.1"
                     /translation="MSSEIYSYLYEKILDEKALDIYTESIYMKKNRPATKVSILCSES
                     DLEKFIKILLLETSTFGVRYNAYNREILERKFVKLDTKYGVVTVKLGYYKGKLVKATP
                     EYNECKTIAKNEDIPIKKVFADINFRIKEEFSENLLT"
     regulatory      49962..50063
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            50284..51819
                     /gene="guaA"
                     /locus_tag="KNP36_000192"
     CDS             50284..51819
                     /gene="guaA"
                     /locus_tag="KNP36_000192"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HBF0872090.1"
                     /translation="MKHELVLVIDFGGQYNQLIARRVRENNVYCEILPCTASIERIKE
                     KNPKGIIFTGGPNSAYLEDSPTISKEIFELGVPILGICYGIQIMSHVLGGVVRKGNKQ
                     EKEYGKTAITYGKSSLFEGITTNSVWMSHTDLIEKVPEGFTIVANTNDCPVAAMENVE
                     RNLYGVQFHPEVEHCLEGDKILTNFLYNICKVKGDWTTDSFIEDKIKELKEKIGDKKA
                     LCALSGGVDSSVAAVLIHKAIGDNLTCIFVDHGLLRKNEGNDVERIFREKFDINLIRV
                     NAEDRFLSKLKGVSEPEAKRKIIGEEFIRVFEEESNKLGKMDFLVQGTIYPDVIESGH
                     GNAATIKSHHNVGGIPEDVDFQEIVEPLRELFKDEVRKIGLELGIEEGLIFRHPFPGP
                     GLGIRVIGDVTKEKCDILREADAVYMDELRKAGLYREIWQAFATLPDVKTVGVMGDER
                     TYAYLVGLRAVTSSDGMTSDWYKMPYDVLERISNRIINEVDGVNRVVYDITSKPPGTI
                     EWE"
     gene            complement(51896..52942)
                     /locus_tag="KNP36_000193"
     CDS             complement(51896..52942)
                     /locus_tag="KNP36_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003460085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBF0872091.1"
                     /translation="MPAYKDEQRKSWYASFYFTDFDGDRKKKIKRGFKTKKEALEFER
                     EFLNKSKMSTDMSFESLIEEYMHDMSSRLKLSTLETKKYLINFRILPFFKSLKINEIT
                     ATHIRRWQNELLKSDYSQTYIKTINNQLVAVLNYAVKYYNLPSNPAHLAGSIGKKNAD
                     EMNFWTLEEFKKFIEFEKKSEPRLAFEILFWTGLRLGELLALTPKDIFENKISVEKSY
                     IRLNGEDIVSSPKTPKSKRVVPIPHFLYNNIKDYLSKLYDLKDNERIFKFAKSYLSKE
                     LDRCCKLSNVKRIRVHDLRHSHASLLVNMDVNILTIAERLGHEKVETTWNTYSHLYPN
                     KQLEVAQKLDNLNI"
     gene            complement(53019..53234)
                     /locus_tag="KNP36_000194"
     CDS             complement(53019..53234)
                     /locus_tag="KNP36_000194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872092.1"
                     /translation="MLKKLRKKKRMTQLELAEKMRRNRSYISKLENQEYKDIGISTIL
                     DLSIALEEDFLELCKYYKLQEIKRRGK"
     gene            complement(53668..54069)
                     /locus_tag="KNP36_000195"
     CDS             complement(53668..54069)
                     /locus_tag="KNP36_000195"
                     /inference="COORDINATES: protein motif:HMM:NF013540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872093.1"
                     /translation="MQTLAEIIKEYRSEHNLSLREFSNLCGVSHTYIDKIEKNRDPRN
                     GKAVEPTLDMLEKMSFGLNLTLKELLTKLGKIQPNTQQDDELLKKVNSKEDNEVNELI
                     NRLASLDSDDKNAIKKMIDNAYYKAVNTKKE"
     gene            54234..54446
                     /locus_tag="KNP36_000196"
     CDS             54234..54446
                     /locus_tag="KNP36_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872094.1"
                     /translation="MKNNLQYIRKESRISQKKFADKIGISRPYLSRIENGKVNPSLEI
                     AHKISLETGKTINEIFFDFTVNHSKL"
     gene            complement(54741..54959)
                     /locus_tag="KNP36_000197"
     CDS             complement(54741..54959)
                     /locus_tag="KNP36_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872095.1"
                     /translation="MTKFKDNIKLVRKQMNMTQKQFASLFGISERAYQYYESGSREPN
                     IETLILISNKLNVSTDFLLGLSPNQNRN"
     gene            55078..55266
                     /locus_tag="KNP36_000198"
     CDS             55078..55266
                     /locus_tag="KNP36_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014017802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872096.1"
                     /translation="MNNNLKLQREKVGLTQLEVAQKAKITERSYQYYEAGERLPNIRT
                     ALKIARILNTNCEKLFNE"
     gene            55308..56072
                     /locus_tag="KNP36_000199"
     CDS             55308..56072
                     /locus_tag="KNP36_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rha family transcriptional regulator"
                     /protein_id="HBF0872097.1"
                     /translation="MNNLQLNNKNTITTLEIADMLEINHWEVLRKLEGTEKTKGIIDI
                     LNDNNFVVVDYFIKSAYLDLKNENRKCYNVTKLGCDFLANKFTGEKGIIFTARYVKRF
                     NKMEQELKEQQPKLPTTYKEALQQLLIEVEEKEQLQLENQAMKPKADYFDALVERNLL
                     TNIRDTAKELGVKEKVFVSWLIEKKYCYRDSKDKLQPYANRMQYFEKKEFTNEYGYSG
                     VQTLINPRGREAIRLLLIKDGLIKEKEKGCQITLLG"
     gene            56119..56328
                     /locus_tag="KNP36_000200"
     CDS             56119..56328
                     /locus_tag="KNP36_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872098.1"
                     /translation="MAKAVAKEQLFYRAKDIAKFLDICEATAYKIIAELNEELEKEGF
                     KTFSGRVSVAYFKERYCYKPRKGVI"
     gene            56329..56469
                     /locus_tag="KNP36_000201"
     CDS             56329..56469
                     /locus_tag="KNP36_000201"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872099.1"
                     /translation="MNVKVLIAYIQFCNDKQIKASFEGLRKYNRDIELVNLYLPTHLK
                     IK"
     gene            56485..56697
                     /locus_tag="KNP36_000202"
     CDS             56485..56697
                     /locus_tag="KNP36_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872100.1"
                     /translation="MVFNLEEFKVGNAVRISCERFGFEIDCIVVVATEKELNLAYFDK
                     ERGCMEYQALIPEDLRYDDYILERLG"
     gene            56711..56881
                     /locus_tag="KNP36_000203"
     CDS             56711..56881
                     /locus_tag="KNP36_000203"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872101.1"
                     /translation="METAISIAKGQIEGANESIKELKSKENYDKESLRWWEGVKQASE
                     NILEFLEIENKA"
     gene            56963..58915
                     /locus_tag="KNP36_000204"
     CDS             56963..58915
                     /locus_tag="KNP36_000204"
                     /inference="COORDINATES: protein motif:HMM:NF022840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2813 domain-containing protein"
                     /protein_id="HBF0872102.1"
                     /translation="MKAILLKGLEIENFKGIKELRIDFNNITNIFGENATGKTSIFDA
                     FTWVMFDKDSKNRSVFEIKPLDKQNKVIRGLVTTVTAVLEVNNKEIKLTKKYEEKWTR
                     KRGESEATFTKNETTYMINDTPIKKSEYVKEIAEIADEEQFKLLTNPYFFSNELNWKK
                     AREVILEICGDITIEQIIESNKDLVLLTTEFEKENNIDKIIKNRKASKNNLSKEKEEI
                     PVRINECNKGMYNIDFEEIEVQLKAKKSDLEAIEDNLLNGTKTNEQILKDKEKIFELK
                     QETQSIKQSASKKGNKKRNELLKEKDELQYNIKNLRNNLVYLERDSELKETLRKRAIE
                     KTTNLRDKWTKKSQETLDLSVIQTECPTCKRPLDLEDIEEKKKEMLDNFNLNKAKELK
                     EIVELGKSKNDDVELFNTEIERLKVDINKTLEEIQEKAVLLDKIKKELESTKSTEIYS
                     ADEEKRLTEISVEIKELEEKINNKDNDKNIDELKESKKKLAVEIELLNKELAKRDINK
                     GLLDRKEQLLEKEKELGIELAHQEKILNLCELFIKTKVSLLESNISSKFKNVTFKLFK
                     EQINGGIEETCEALVDGVPFSNVNTAGQINGGLDIINTLSNHFGVKMPIFIDNRESVN
                     DLIDIDSQVINLIVSNDNPLKIKGVN"
     gene            58917..59786
                     /locus_tag="KNP36_000205"
     CDS             58917..59786
                     /locus_tag="KNP36_000205"
                     /inference="COORDINATES: protein motif:HMM:TIGR00616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecT"
                     /protein_id="HBF0872103.1"
                     /translation="MANEIQRQVSVKNLLSTEAYKKRFKEVLKDKANTFMASVVNVSN
                     LPSLKDAEPNSILKSAMVAATLDLPIDPNLGFSYLVPFVNKGVKEAQFQIGYKGFIQL
                     AMRTGQYKTINAIEIYENEIKSVNRLTGEIEFNENKDEIDNEIVVGYIAYFKLLNGFE
                     KTLYMSKEDMEKYAKRYSQTYKSNKDYVVKSSLWTTDFDAMAVKTVLKRLLSKYGILS
                     IEMQKALETDQAVIKDDNSVEYVDRQVEEEIEENANKKTIDMTTEEKEKAIEIKESKP
                     EEATQVELDTPPF"
     gene            59789..60502
                     /locus_tag="KNP36_000206"
     CDS             59789..60502
                     /locus_tag="KNP36_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015615677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0872104.1"
                     /translation="MKIKVLGSSSRGNCYLLQLKNETLILECGVSYKEILKGLDFSLE
                     NVVGCLVTHEHKDHSKAITELTNNGIDVYSSKGTLEALKIENHRTKIIESEKLFKIGN
                     FKIVPFNTKHDAVEPLGFLINHSSFGNLLFITDSYYCEYNFNNLNHIMIECNYSKDLL
                     DNNKDKIYLRNRIVKSHFELSNVINFLKVNDLSNIKTITLLHLSEDNSDKDLFIREIE
                     KNVGVPVIVAEKGLEIYLD"
     gene            60660..61406
                     /locus_tag="KNP36_000207"
     CDS             60660..61406
                     /locus_tag="KNP36_000207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HBF0872105.1"
                     /translation="MEMQTGYNRETVEKLIKRFIEYGKIKYDSTTKEILIINWSKHNF
                     SKSPKVRTCILKEVESIKNKEFQQYMYRVCIDYGYPIDTVSIDYGEKEKEKQKEKEKQ
                     KEKEKQKEKVEPLICEEQEKNELKEFKKLYEENIGVVYPVTAEWLIEISSDVDIRLFK
                     SAIEICAEKMNMNIAYLKGILKKWKDANITTYEQLESYRLQQENKKAKKVVNGQLSKN
                     KFANFEQTFTKYTENELDNIIKKSQDAKFK"
     gene            61464..61811
                     /locus_tag="KNP36_000208"
     CDS             61464..61811
                     /locus_tag="KNP36_000208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872106.1"
                     /translation="MGKIWMDAGTFLETKDIGDIECNLREMINKNKQKNLIGRINSKG
                     QGRKSKKVECTNIITGESKIFVSAVEASEYLYFTELHITRLARTGKTTKNGWKVRYIE
                     EVSNGISKCGTSN"
     gene            61780..61917
                     /locus_tag="KNP36_000209"
     CDS             61780..61917
                     /locus_tag="KNP36_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872107.1"
                     /translation="MVLANVEQVIKLAEKILSKKKCSVNKAIDIAIKILNRYEYEGMI
                     K"
     gene            61914..62363
                     /locus_tag="KNP36_000210"
     CDS             61914..62363
                     /locus_tag="KNP36_000210"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872108.1"
                     /translation="MSLIEYRGYDFENKKWIYSKTIMWSNAVDCLLMLKEDFKWRKVC
                     NVGICSEEWAGNNQEIFEGDILKENYNPHNRSSYGIVKRDFNSIKLYLEWHYLKKFEG
                     EWIEIIDKTEIYHSRGYKVIGNEYENLEEVRKEFLERKEMLENERLS"
     gene            62465..62623
                     /locus_tag="KNP36_000211"
     CDS             62465..62623
                     /locus_tag="KNP36_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872109.1"
                     /translation="MNDRLEMINASVNYIQMICESSNIAIIAEHDRVRILDLETKEKY
                     DLLRSEGD"
     gene            62627..62950
                     /locus_tag="KNP36_000212"
     CDS             62627..62950
                     /locus_tag="KNP36_000212"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872110.1"
                     /translation="MSKVIQCDFCKEIFEKYNGECIELYKKDCSKGVLGIDKHICPTC
                     YEKFIEGKIEKVENAKRFKDKLIDFLVEHEVCDCCACDCVFDSNDEKKCKAGIREWVE
                     SEVEE"
     gene            62952..63251
                     /locus_tag="KNP36_000213"
     CDS             62952..63251
                     /locus_tag="KNP36_000213"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872111.1"
                     /translation="MAKLIVSIPLTKYLKDITKEWGETYITKTYGGHVYLSDEAPGEV
                     LKKEDDLNYIEFNDSDIVMRLPKEVHQHINLKKGCNKNLKDVLKEIKKIEEKTNI"
     gene            63359..64255
                     /locus_tag="KNP36_000214"
     CDS             63359..64255
                     /locus_tag="KNP36_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HBF0872112.1"
                     /translation="MLTFLDLFAGIGGFRLGMEKAGHKCLGHCEYDKFANLSYNAMHK
                     PKEDEWFERDIREIRTENIPRADVWCFGFPCQDISVAGKQFGFKGRRSSLFFAVTKLI
                     RELKEEDRPKYLLIENVKNLLSVNGGFDFLKVLIELDEIGYDAEWQVLNSKNFGVPQN
                     RERIFVVGHFRGRSTRKVFPIERKSRKNLEQLNNPTHSTSGVLVNAVLTPDRVNKRQN
                     GRRIKESGEPMFTLTAQDKHGILKNGDIRRLTPKECFRLQGFPDKYYERAASVCSDSQ
                     LYKQAGNAVTANVVYEIAKRMG"
     gene            64334..64555
                     /locus_tag="KNP36_000215"
     CDS             64334..64555
                     /locus_tag="KNP36_000215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872113.1"
                     /translation="MSKYVLRWQKGLLLDERKINYSCGSKEMLKQKAELLAKDDKILL
                     VTIDKVEEVIKDTRSQKMAEYYCDGGIEI"
     gene            64552..65556
                     /locus_tag="KNP36_000216"
     CDS             64552..65556
                     /locus_tag="KNP36_000216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBF0872114.1"
                     /translation="MIIHKFIIHVLDKNSDTPILNDFEGRVSQDIEAFFQKKISKVSR
                     DNDIRTVVFNDYSNNLIKKCCEQIIYDESSFLNNSKEIAAYLFDVMKLNAILESCDLA
                     ICLYSQKDEKKVAILKLDYNNSYTHSISFEEDKFNIQMSKNEINIQETKTVKIAALVG
                     LSGMNDEYHLKVLDKDAEKEEANSKFVTEFLNATKVKDDKYRTKKFKDTVENWITNVL
                     GNDIKQAEDIRSILNYTLKEKHEIDIKDFVDKSIKDDELKNSFKEHMEEKGLDESFSI
                     DKKWVEKKLKKRNIKTDNGFEIKGNLTDFEDPMKYTVRQNQNGSIDIIIKNVNFYNEK
                     "
     gene            65567..65857
                     /locus_tag="KNP36_000217"
     CDS             65567..65857
                     /locus_tag="KNP36_000217"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872115.1"
                     /translation="MENKDNFVLNKLGPASKVMKKVEIDEKEIKSYLKELKECEEVKV
                     FIIRKDGIEIPIVFKDGNMNEWLRKEIEISFDRFKDEIAQVKKALIKVTGEN"
     gene            65877..66044
                     /locus_tag="KNP36_000218"
     CDS             65877..66044
                     /locus_tag="KNP36_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872116.1"
                     /translation="MTNKEMCKSNNLDEREVCKEFGKEICGSCINDRVDCESKDCDIA
                     YENWLEKNTER"
     gene            66130..66471
                     /locus_tag="KNP36_000219"
     CDS             66130..66471
                     /locus_tag="KNP36_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor-like protein"
                     /protein_id="HBF0872117.1"
                     /translation="MANIYCENYNCKNYFEDMCMLERIEINNLKVCESYIEGKNELYK
                     LENGYTIHPKDLKMVKSKDYSVEVTHIPTGITVKCRSTNSILKNKNKCLEVLEEELIK
                     INSHLELEDLN"
     gene            66597..67004
                     /locus_tag="KNP36_000220"
     CDS             66597..67004
                     /locus_tag="KNP36_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBF0872118.1"
                     /translation="MKVFLVIDGEPVGKERPRMNTYAKRTYTPNKTKNYEDLIKWLYQ
                     SKVKYYFEGYIKMTLRCYYSIAKSNSKKVKEQKRNNVLRPSKKPDIDNVIKVVADSLN
                     EIAYKDDTQIVEVVASKYYSDKPRVEVILEDVI"
     gene            67106..67960
                     /locus_tag="KNP36_000221"
     CDS             67106..67960
                     /locus_tag="KNP36_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015994384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HBF0872119.1"
                     /translation="MNENINKEITVLGTLEIEGMKFHNIEGGFGEHKKAMLVKDIAEI
                     HNRELKHINELINNNIKRFKTNIDIIDLKVSRSERLGDLKANPFEGLGYEDVGYSKQS
                     FNQSRNIYLLSERGYSKLLKILEDDKAWEQYEKIVDGYFSMRKELNNPLLSASKELQA
                     IFMLDKKQEVLETKIENVNEKLENFMDDAPLFNIECECIVKEVKRVATKSLGGHGSKA
                     YKNKSLRGKVYSDIYHQIKREFGVDSYKAIKRCQLDKVLEIVNNYKLPIVFEEEIRLL
                     NSQLSIVS"
     gene            68112..68618
                     /locus_tag="KNP36_000222"
     CDS             68112..68618
                     /locus_tag="KNP36_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016056376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872120.1"
                     /translation="MSKTKKEFFNATKKQLSNYKQLSANIIKLKNEIQMLKDNSVGDL
                     MKGISYDSVKTGKTNKTSNMIEDAIVNVSDLITEKEIELYEAEIIKSTIDLAIRNLKP
                     IHRQIIELKYIDGLMWQEMVDIVHLEERQLSVRASQAISSISIALFGKKALIEQEPLF
                     ELLDYKLN"
     gene            69371..69544
                     /locus_tag="KNP36_000223"
     CDS             69371..69544
                     /locus_tag="KNP36_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872121.1"
                     /translation="MATKSILKNVDVRKKAFGRNLVSALENAKNKQEKEVVLSKKCSE
                     VPKDKIKDIFGRF"
     gene            69544..70155
                     /locus_tag="KNP36_000224"
     CDS             69544..70155
                     /locus_tag="KNP36_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase"
                     /protein_id="HBF0872122.1"
                     /translation="MSGYLIVNLSNMLGELEEEEVKKILSSFSCPLNKDVEDFLKNKA
                     IEFSKQGLASTHLVLTSYKGKPVIVGYFTLANKYFTIKRKTLTNSLARKVVKFGQYNE
                     ELRRYIIGAPLIGQIGKNYSNNYNKLIKGDELLKIACDKIKAVQLDMGGKIVYLECED
                     KPKLIEFYKDNGFVDFGKRSLDKDETDSLDGDYLVQMLKYLKK"
     gene            70232..70858
                     /locus_tag="KNP36_000225"
     CDS             70232..70858
                     /locus_tag="KNP36_000225"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872123.1"
                     /translation="MKKITKLILCSLLVISIASPLQVEAKTTHHSSSHVSIHKSSTKS
                     KSSRPKITKTKKATKTYRTNKSIKKKIKLKKQVNKKTQVPNKQAARKDKKTTTYNYYN
                     SYNSNRYYTTSSSGLSFWDCYMLGHLFNNNNKVSEQDIARELQKQGYSKQETDNILRK
                     ANQNQAKKEEKKKRVMMLIFSVLGALFIIGLGLIIFIKRESKGCNKSM"
     gene            70931..71620
                     /locus_tag="KNP36_000226"
     CDS             70931..71620
                     /locus_tag="KNP36_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872124.1"
                     /translation="MNEKADLAHEDYLKGLKYKEIAEKHNVSLSTVKSWATRYWKQKG
                     CNQSKKVATKKRGAPIGNKNATGPPGNKNAEKFGFFSKYLPEETRELMQEISIKDKFD
                     ILWEQITIQYAAIIRAQKIMYVKDKEEMIKELKKHESTENGEKIEYEFQFAWDRQASF
                     LNAQSRAMSELRSLIKQYDEMIHKDWNLATEEQKTRVEKLKCEVDNLSKDDIGDDELK
                     ISVDYGDRNDS"
     gene            71598..72851
                     /locus_tag="KNP36_000227"
     CDS             71598..72851
                     /locus_tag="KNP36_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PBSX family phage terminase large subunit"
                     /protein_id="HBF0872125.1"
                     /translation="MVIEMIVRVNFNPDFKEANFTKKRYRAMKGSAGSGKSVNVAQDY
                     ILKLGDKKYQGANLLVVRKSEATHKYSTYAELTGAINRIYGKQADKYWKTTLNPLEIK
                     SKVTGNSIIFRGVNDAKQREKLKSINFSKGKLTWVWCEEATELMESDIDILDDRLRGI
                     LTNPNLYYQMTFTFNPVSSTHWIKRKYFDYKNDDIFTHHSTYLQNRFIDEAYYRRMQM
                     RKEQDPEGYKVYGLGEWGETGGAILKNYVIHEFPTEFEYFDNMRLSQDFGFNHANVVL
                     RIGFKDGELYICNEIYVHEMDTSEIIKIANSKGLEKNIFMYCDSAEPDRIKMWKSAGY
                     KAKGVKKGPGSVKAQIDYLKQLRIHVHPSCTNTIKEIQQWKWKQDERTGLYLDEPVEF
                     MDDAMAALRYSIDNKLKNNGISFLK"
     gene            72866..74296
                     /locus_tag="KNP36_000228"
     CDS             72866..74296
                     /locus_tag="KNP36_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBF0872126.1"
                     /translation="MYISETDLIKVQLKKESTFNLVKVIEHYILKHRPEKYKQGEEYY
                     YGNADINNKRRYYLLDGAKVDDFTKVNNKAINNYHKLLVDQKVGYSVGNPIVFNADDD
                     NLTKLLNDLLGEEFDDTITELYLNASNKGVEWLHPYINRKGEFKYVIIPAEEAIPIWD
                     SKRQRELVAFIRFYYIEDIDGNKIKRVEYYTENDVTYFIERGNSFIQEFLYDEYGKMT
                     DIQEGHFRINNKEQGWGKVPFIPFKNNEKCVSDLTFYKSLIDIYDNNISTLADNLDEI
                     QEVIYVLKEYPGTSLQEFIDNIRYYKSIKVDGGGGVDKLEINIPVEAKKELLDRLEKN
                     IIIFGQGVNPESQNTGDKSGVALKFLYSLLDLKCSKTEKKFKKAIRELLWFVCEYLKI
                     SGNKSYDYKTVQITFNHSMIINEAEKIDMAAKSTGIVSDETIVSNHPWVEDVNDELER
                     LKKQEDTQKEYDDLIPNNQDGVIDET"
     gene            74286..75647
                     /locus_tag="KNP36_000229"
     CDS             74286..75647
                     /locus_tag="KNP36_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013657754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="minor capsid protein"
                     /protein_id="HBF0872127.1"
                     /translation="MKHKDYWRKRFEQLEEAQNNKSIKYYLELEKQYKLAMSNIEKDI
                     LIWYNRFTENEGISLLEAKKLLNTRELEEFKWSVEEYIKYGKENAINQKWMKELENAS
                     ARVHITRLEALKLQIQQQVEVLYGNELDGIDKLMRDIYTSGYYHTAFNVQQGVNVGWS
                     LMSLDTNRINKVISKPWTSDGLNFSERIWGKHRPALINELHTKLTQSIIRGENPKVLV
                     NEFSKKFNVSKSQAKNLIMTESAFFASASRKDCFNDLDVEKYEIIATLDLKTSNICRE
                     LDGKVFDMKDYQVGITAPPFHCHCRTTTAPWFEDEEGYRAARDENGKTYYVPSGMKYK
                     EWYEKTFITDKKDDILSNKSWLKADFPTEKKFKKHVEKHLNEYGNITAEEYLSTARNL
                     LSEQLSNDVEGFLSKDNFLFKYRKSTNDFAVGRADGKISTLFKPKEGYNYWLEQIKEY
                     KEV"
     gene            75650..75811
                     /locus_tag="KNP36_000230"
     CDS             75650..75811
                     /locus_tag="KNP36_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003495392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872128.1"
                     /translation="MNCPVCGKDVDVFDICDNCNWQNSGPKETNYKGPNKMSLKEAKE
                     AYEKGKKVI"
     gene            76143..76535
                     /locus_tag="KNP36_000231"
     CDS             76143..76535
                     /locus_tag="KNP36_000231"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872129.1"
                     /translation="MAKFKKKSEEVEAFKWILGSPNTPIWFYQAFEKGTIWLDESLNS
                     VNRKGEVKKTICIKYKNGVIRATNGDWIIKDSEGKIYSCTCDEFEKYYKDLDNETKIS
                     NGGLECLREIALKDVNFKFELTGIKEEK"
     gene            76536..76733
                     /locus_tag="KNP36_000232"
     CDS             76536..76733
                     /locus_tag="KNP36_000232"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872130.1"
                     /translation="MFYLLLQVISICLSITVFMYVTGNIVFKIYLKSLRKEYESNIHE
                     VSDEILKRIRKELNKSLDESL"
     gene            76776..77006
                     /locus_tag="KNP36_000233"
     CDS             76776..77006
                     /locus_tag="KNP36_000233"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872131.1"
                     /translation="MKEYMIWFKSGNSISGIVDEDVADKLMQDFMEADSDCKDLKVYL
                     DEDGTTVIDLSQIEAISINNCNENNNIGFSKS"
     gene            77051..77614
                     /locus_tag="KNP36_000234"
     CDS             77051..77614
                     /locus_tag="KNP36_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage scaffolding protein"
                     /protein_id="HBF0872132.1"
                     /translation="MDWLKELLEGIKVEDNKIDVASLQKSIEKKIKETTITKEDYTNL
                     ETQLNTANETIKKFEGGMTKEDVENLKTTYETDKKTLEETYKKEIEEKDFNYWLNDAF
                     KSIKCRDEIALKAHLDIEALRNSKDRQKAFEEQINPLKQDKDYLFNATLEGEEPKIDT
                     ITPGQEPKINDFGFNFTGVRPHENNNK"
     gene            77626..78525
                     /locus_tag="KNP36_000235"
     CDS             77626..78525
                     /locus_tag="KNP36_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsid protein"
                     /protein_id="HBF0872133.1"
                     /translation="MAALNYAKEYSNVLAQAYPYTLNFGDLYATPNNGRYRWTGSKTI
                     EIPTISTTGRVDSNRDTIAVAQRNYDNAWEPKVLTNQRKWSTLVHPADINQTNYVASI
                     GNITKVYNEEQKFPEMDAYCISKIYADWTALGNTADTTVLTTTNVLEVFDKLMEKMTE
                     ARVPENGRILYVTPVVNTLIKNAKEIQRTVNIKDGGTSLNRQTTDIDTVKIIKVPSNL
                     MKTAYDFTTGWKVGAGAKQIFMSLVHPSAIITPVSYQFSKLDEPTAVTEGKYFYFEES
                     FEDVFILNKKADAIQFVVEGAGA"
     gene            78525..78758
                     /locus_tag="KNP36_000236"
     CDS             78525..78758
                     /locus_tag="KNP36_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872134.1"
                     /translation="MAQVRKLNRILTIEECKIDDFLEMGYDLIDETGKAVKYGKSLNV
                     KDLIAENNILRSKVESLEEENKQLKEKNKLTKK"
     gene            78768..79169
                     /locus_tag="KNP36_000237"
     CDS             78768..79169
                     /locus_tag="KNP36_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872135.1"
                     /translation="MENNMIDDIERRLQGFGYVLKDGDKWLIDFVREKIENIIKLDCN
                     ISEIPKELHNIEIDMIAGEFLFTKKNMGQLDIESINFEAVEKSISEGDTKVDFAIGSG
                     SQTPEQRFDSLVAYLTTYGKNNILTFRCLRW"
     gene            79163..79510
                     /locus_tag="KNP36_000238"
     CDS             79163..79510
                     /locus_tag="KNP36_000238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872136.1"
                     /translation="MVSKTRKAIEMLYRDKCTIVEYQPIKDPVTKRTNNKEVIVLENQ
                     PCKLSYKNITSATDGKVAKLEQTIKLFISPNIEIKAGSKLIINDKEYVRSGESALYPN
                     HQEIILELFKDKA"
     gene            79510..79800
                     /locus_tag="KNP36_000239"
     CDS             79510..79800
                     /locus_tag="KNP36_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 gp10 family phage protein"
                     /protein_id="HBF0872137.1"
                     /translation="MARWGSVDFREFKRVCKKMEKLTKIDLDKFCKDAAKELAARLIG
                     KAIKRTPVDTGFLRQGWSGVAYARSLPVYKQGNNYIIEVVNPTEYALTQWGI"
     gene            79910..80716
                     /locus_tag="KNP36_000240"
     CDS             79910..80716
                     /locus_tag="KNP36_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872138.1"
                     /translation="MAKFLDITGKKFGRLRVIKFSKEIKSGKRNRKYWLCKCDCGNFK
                     EIRTDSLTSGLVQSCGCLKKEQDKLNLTDKYQFKKKYKVQNKRLYSIWKGIISRCTDK
                     NNKRYNRYGERNIIVCDEWFCYDNFANWALSNGYSEKLTIDRINNEGNYESSNCRWVD
                     IKTQCRNRSTNILVKHEEKEITLIELSEKTGISYSCLRSRYSKGLVGNNLIEKVKIIE
                     ESRAKLSIEDVKEIRKKYSDGYTIKQLSEIYPVTYSSISNIVHRRTWKNI"
     gene            81065..81502
                     /locus_tag="KNP36_000241"
     CDS             81065..81502
                     /locus_tag="KNP36_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872139.1"
                     /translation="MLNNIIDGISIKLDKTFGESYTIYSEDVEQGINEPCFFIVPLNP
                     SKVSYPSGRTLKKNSFDVHYFPKSNDKSFEIDEVAEMLLEELEYIEIDGDLVRGTNMN
                     FEIVDNVLHFFVDYNYFTIKNNDINKMDTVELFGGLKRGDNFE"
     gene            81495..81671
                     /locus_tag="KNP36_000242"
     CDS             81495..81671
                     /locus_tag="KNP36_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872140.1"
                     /translation="MSKTLSKGTDYKFTKEQIVNSKKYINRKDLLNAILKENELYSFS
                     EVEEIINSFMKGVS"
     gene            81673..82983
                     /locus_tag="KNP36_000243"
     CDS             81673..82983
                     /locus_tag="KNP36_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath family protein"
                     /protein_id="HBF0872141.1"
                     /translation="MALGGGTFVTQNKILPGSYINFISAKRATSSLSDRGIVAIPLEL
                     DWGIDEDVFQVTSDDFEKYSVKYFGYDYTHEKLKGLRDLFKNIRLGYFYKLNKGVKAS
                     CTIATAKYSGIRGNDLKVTVTTNIDDNAKFDVVTLLDNKKVDTQIAKVITDLQDNDYI
                     TWKKDATLEASAGLVFTGGTNGEAVTGAEYQAFLDKIESYSFNALGCLATTTEIKSLF
                     VEFTKRMRDKVGAKFQTVLYKKSDADYEGVVSVENKIKDIGLVESSLIYWAAGVIAGC
                     DINKSNTNKKYDGEFDVDVNYTQIQLEEALKTGKFIFHKVGDEVHVLEDINTFVSFTD
                     DKNDDFSSNQSVRVLDQIANDIATLFNEKYLGKVPNDKAGRISFWNDVVKHHKELENI
                     RAIEDFKTDDVSVELGNDKKTVIVSDAVKVINAMSKLYMTVSVN"
     gene            83000..83470
                     /locus_tag="KNP36_000244"
     CDS             83000..83470
                     /locus_tag="KNP36_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tube protein"
                     /protein_id="HBF0872142.1"
                     /translation="MAQTINAKDTVSAKKAECFITIEGKRYNFMQAIDLEAKMEKNKS
                     EVPILGRTTKGNKTTGSTNTGSATFHYNTSIFRELLYRYKETGEDIYFDIQVTNEDPT
                     SAVGRQTVVLKDCNMDSGIITKFDADGEYLDEDMDFTFEDWELVEKFNLLAGME"
     gene            83542..83982
                     /locus_tag="KNP36_000245"
     CDS             83542..83982
                     /locus_tag="KNP36_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBF0872143.1"
                     /translation="MSNLSAFLSQNAIKVDNVKYVASNRFLDKEGKPVEWELKVLSSE
                     EDEALRRKCTKRVKVIGNNGKHTGQYTSEIDYNSYVAELCVASTVFPDLKDAELQNSY
                     GVMGEAQLLKTMLTAGEYVNYTVKVNEVNGFDTSFEDKVEEAKN"
     gene            84323..84484
                     /locus_tag="KNP36_000246"
     CDS             84323..84484
                     /locus_tag="KNP36_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872144.1"
                     /translation="MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFD
                     FKIKFHKFK"
     gene            85196..85475
                     /locus_tag="KNP36_000247"
                     /pseudo
     CDS             85196..85475
                     /locus_tag="KNP36_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420334.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(85829..86041)
                     /locus_tag="KNP36_000248"
     CDS             complement(85829..86041)
                     /locus_tag="KNP36_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872145.1"
                     /translation="MSIKFFKLINLLNRRGITKEELRLKIGASSTTIAKLSSNKNVSL
                     DVIDKICKALDCQPGDIMEYEDDEKL"
BASE COUNT        34361 a         9199 c        14833 g        27696 t
ORIGIN      
        1 tttaattcta attatatatt ataaataaag tatgtgtata ttaaggaggt aatatgaagt
       61 ttttaaatgt tttagtagta gttgaagata ttgagaaatc aaaaaagttt tattatgatg
      121 ttttggggtt aaaggtaatc tgtgattttg gagaaaatgt tgtattagaa ggtaatatat
      181 cattacaaga aaaaaagctt tggttagaat ttattaataa gagtgacagt gaagttaagt
      241 tcaatggaaa tgatgctgag ttatattttg aggaagataa ttttgatact tttgttgaaa
      301 gattgagtac aatgaaagat atagattatg ttcatctagc tatagagcat aggtggggtc
      361 aaagagcaat tagattttat gatttagatg ggcatattat tgaggttgga gaaactatgt
      421 catctgtgtg tagacgtttt ttagatagtg gtctttcaat agatgaggta gctaaaagaa
      481 tggatgtaac tgtcgaatat attgaatcag ttttagaata gatggattat attaaagtaa
      541 aattgaggtg aaggctgtaa gtaaacttgt gtgaaaacaa atttgcttac agtttttatt
      601 tttctaaaat aaagaatata atacttgttt agctttattt gagtttttaa aaatattatg
      661 atatttctta tatatttata ctaaagttta aatttagaaa aaatatataa aagatagtta
      721 tatttactat tatcttgtat aattatatat actattttat ataactatgc taaaatttaa
      781 ttgaataaat taaaaatata atgaaagttt agttttaatt catttattta ataaacattt
      841 caagtaaaat aatgtttaaa tcagaaatat aaataaatat tattataatc gttattaaag
      901 accaaaaatc ccaccttaga agtttgtatc atatgaaacc tttatagatt atgaaagcaa
      961 taatatagtg tatgatatat aaaataagtt ataaaagtat ttttttagat attcaaaaag
     1021 acattgtaag ttatattaat aatatgggta tcaacgaatt ttggatataa tgagtttttc
     1081 aacttaaagt tatgtaataa tgaatgtaaa gaatatttaa tgaaatcatt ttgttggtta
     1141 tgtctagctg aatacaataa tcttttagat aaagatttta tatttgaaga taggtgtgaa
     1201 aaaattaaga agatattaac atcagcagtt tagaggcaaa gcatgtaaag taaagtctgg
     1261 gtaactaaaa gtagtaattt agattgtaac tattgttata aatatgaaaa tgaggaaaca
     1321 ggaaatataa gttaggatgt agaaaatagg ttactaaata aaaagcttaa ttatataatc
     1381 aaagaaatag gtatatactg tacaatttca tggtgaagaa cttttcctaa ataaaaaggt
     1441 tggtaaaaga gatataagaa ataaaattca attataagat atggtatgat aactaaaggc
     1501 actatatgga gtgaataggc ggaagaattt tttgaaaatt ataaaaatag tttctgttgc
     1561 tacatatcaa taagtataga tagagattgc aaaatccata gcaaaaatcg aatttataag
     1621 tgtaaataac atgtaagaca aggagtaaat tatgagtatt ttagagataa aaaacctaaa
     1681 taaaatatat ggtaaatcgg aaacagaggt gaaagcgtta agtcaaataa atctaaaaat
     1741 aaatagtgga gaatttgttg tgatagtagg taaaagtgga agtgggaaaa gtactttact
     1801 acacataatg gcaggacttg aaactccaac aaatggtgat gtgattattg ataatataaa
     1861 tatatcatct cttgatgaaa agaaaagatc tgcattacgt aaagaaaagt tgggattaat
     1921 atttcaatca tataatttga ttccagtttt aactgttgaa gaaaatataa aactaccaac
     1981 tataaatata aaaaataaag atgaagctta tattaatgaa ttgatggagt tactaggaat
     2041 aaaagataga agaatgtatt tgccaaatca attatcaggt gggcaacaac aaagagtagc
     2101 aatagcaagg gctcttgtaa ataaaccatc aattgtattt gctgatgaac ctactggaaa
     2161 tttagacaca aagacagagt cagatgtatt aagtttatta aaagaatctc aaaaaaaata
     2221 taatcagaca ataataatga taacacataa tatagatata acaaaatatg ctgatagagt
     2281 tatagaaata gaagatggat ttataagaga gtaggtagat ttatgaaact taattatatt
     2341 gtaaaaaaat atataatggg aaataagaaa aatacattat taataattgt aagtattgta
     2401 atttcaacag cgttgttttt aattatgaat ataataagtg aagatgcgac aaacttaatg
     2461 ataaatcaag ctaaaaatga atttacatta aaacatgcac aatatatcaa tccaaaagac
     2521 gaagaaataa aatatataga aaataacaca agtatagata aagttggaaa atcaatgctt
     2581 ttaggaatta gtgatattgg taaaggtcaa acactacaaa ttctatctca ggataaagtt
     2641 gctgaagaac taaatgatat ttacacacta gaaaaaggta aattaccagt agctgaaaat
     2701 gaaatcgcta tagattcatg gtatattaaa caaaaaaaga taaaaaaccc tataggaaaa
     2761 aggataacat tagattatag aagacaaggg atagatcaag aagatttata tactggggaa
     2821 aaagaattta aaataactgg tatcttaaat agtaatccta ttttaaaagc tcaaggaaca
     2881 tcaattggcc ttataagtaa cgattgtgct atcaagaata ttcctactaa aaataaatat
     2941 gatcaagtta tgtttacttt taaaaaggaa aaaaatatac agagacaatc acaaaaactt
     3001 attaaaaatg gaaatttgaa tgagaataac atttatttta ataatgaatt attaatagct
     3061 atatctgata gtatgaattt aaaaatacct tatataatag ttaatatagt actagcacta
     3121 gcaactatat tattaattta taatattttt tatatattag tatcaaatag aataaaggat
     3181 tttgggatat ttagggcttt agggtttaat ccaaatgata tttttaaaat aatgatttta
     3241 gaagtatcta tatactctat tataagtatt tctataggtc taattttagg tgggataata
     3301 gctagtttat caagggagta tgttatagga gtaatataca atgtcaacta tataaattct
     3361 ataaaaaacc agaactatat aaacacatac ataatttcta tattattaag tttaggaact
     3421 ataataatat cagtttcaaa acctcttatg ttatcagtta aaactgatcc aatgatttgt
     3481 ataagaagaa ataatgaaaa agtggatata aaacaaaatt cctttataaa taaatttatg
     3541 ataaaacttt tcaaagacta tggtaacata gcatcaaaaa atatacaaag aaataagaaa
     3601 cgtacaaatt tatctatagc atcaatggta attatatttt tcttaatggc aacaatatac
     3661 acaaagtcta ctagtaactt tttaagtgat ggtgtattaa aatattggat acaaggagat
     3721 tatttattac ataatattga tataagtact atacgttcaa ataataaagg ttatgataaa
     3781 aatgtactac aagagataaa ggcaattgat ggtgtaacaa aagtaaactc atataggcat
     3841 aagtggttta atataaaaat tgatgataaa agtataaata agaactctga ttattggaaa
     3901 aaaaataaag ataatattga agctagatca gaagtaaaag atggaattaa ggtatataat
     3961 aattcttttg aatttttagg aatagaagat acagatatac tagaggattt cttgataaat
     4021 ggaaaggaaa atatagataa atttagtaaa caaccatatc tgtatataac aaagaaatcc
     4081 agtgattcgc ttaatataaa aaaaggagat agaataaaag tatactttga tattatagat
     4141 tcaaaaacaa ataattttac caaaacaata tctcaagaat ttatagtatg tggaattata
     4201 actacattac cagtaacctc acaagtggga gctgaatttg gcggagtaat atcaacaaat
     4261 caatttaata agtttacagg aatatcatct tatgaaagat ttgacatatg gacgagtaaa
     4321 ctagccaatg ataaatatgt tgaaagtgag ttaaacaaaa taacagaaaa aacaaataaa
     4381 ggaattttaa ttccatacaa agctgaaaca gctgaatatg aaaaaattga taatcaaaaa
     4441 acactaatta tggtattagt aactggaatt atagttatat tatctttatt taattgttgc
     4501 aatactatag ttactagtat taatagcaga agtagggaat ttgcactatt tagaggaata
     4561 ggaatatcaa aacatgaaat aaataaaatt gttaaattgg aaagttatat atatattata
     4621 gtaagctttt gtatatctat aatacctatt ttaattgtaa gaagtataat aataaaacct
     4681 tttgaaagta tcaatttaat aaattggaaa tttatagggg ctattatact aatagtattt
     4741 attttagtat ctataatcat gataactaca ctaaaaacat tgaataaaat tcaaaatgaa
     4801 aattttatgg aagaaataaa gactttatag tgaacagcct ataaattaaa gaggttttat
     4861 atgaatttaa ttgcaattat cgataatggt gtagatattg attttaaata atttagaaat
     4921 aaaaataaaa taagttatcc aagttatatg tatgatgtaa taggggtaca atgtatagca
     4981 aatataaata ttggcttaat aaaactctac tcttaagtct actgtcgttt taacacaaga
     5041 ctaataataa gtgtaaccta aaaattattg ataatacaat aaccttgttt atgataaata
     5101 acaaatatta agtgttgtaa agatagtaag tttaaaaaaa tatcaaagat ttcaatcaca
     5161 atgtattgtt tatctgtagt gttagctatt tatggtatat atgtatttat aaattgtact
     5221 gaatatatat atactatgct atctacaaaa catttaacag tcaaaggaaa tgaatatacc
     5281 attataaatt attatatgag taactttagt cagtatataa tatttgctat tttacttgca
     5341 tcaatgggat ttgtaataca aaagatagtg catatgcatt tcagtgagat agaacttagt
     5401 ggtaactatt caacaactgt tagaaatata agtgatatct ctttagataa tgataatgaa
     5461 atgtttaata gaggcaatat tgaaaatagt attttaaaaa aataaataat ataaatatat
     5521 aaaatgtgat tgaataaagc ttagaatact tagtgtattt taagcttttt ttattattaa
     5581 gatttcaaag tattaaatta actatataaa atcatataaa aataatttta aaatatttaa
     5641 atcattgatt tcaaggtatt gtatttttaa aagagtaaaa atataataag ttaggtatat
     5701 aatatatata aagtaaaaaa taaaaaaatg gaagtgattg agatgagtag tatattgttg
     5761 gttgaagatg atttaagttt gatatatgga ttagaatatt ctatacaaaa gaatggattt
     5821 agtgttgatg tagcaagaac agtagaagaa gcattgcaaa tttataaaga aaaaaattat
     5881 gatttactgc ttttggatgt atccttacct gatggtgatg gttttgatat ttgtaaaagg
     5941 gtaagagaag cttctaatgt accaatcata tttttaactg cttctgatga agaagtaaat
     6001 gtagtgatgg gacttgatat gggtggagat gattacataa caaaaccttt taaattaaat
     6061 gagttaattt caagaataaa agctttactt agacgttata attttacaag tgaaaatgta
     6121 actgaactaa aatcaaataa tattactgtt aaattacttg aaaatcgtgt ttttaaaaat
     6181 gaaattgagc ttgaacttac tacagcagaa tataaattat tatgcttact tatgaaaaat
     6241 aaaaatattg tacttacaag aaaaaatata ttggataagt tatgggatgg aaatggtagt
     6301 tttgtagatg ataatactct gtcagtatat gtaagaaggt taagaaataa gattgaagat
     6361 aatcctgaaa atccaaaaaa tctattaaca gttagaagaa tgggttacaa atggaatgtt
     6421 ataaagtgag ggtgttaata tgaaggtatt ttctaataaa gacataaaaa tatttttttt
     6481 ggtgattata tccgttttat tgatgtttat agtagtaggt caaatagtag ttataaatat
     6541 aactaatgat tataaaagtg cactgttaga acatgattat aatatagctg gatacttaaa
     6601 tagtatgggt gttgataaat caaaaatacc agcagtattt actactaatg aagataaata
     6661 tactttaaaa ggaaaagaaa tcttaaatac agctagatat gactttggta cagatgatag
     6721 ttttatgcca agtgtgaaat tgtttcaagg taaatatata aaaactatgt ttttgtattt
     6781 atttgtgttc tttactatga ttatttttat attgtatgtg tattttttta ggcaacagaa
     6841 caagatagaa gaagctagtt ataaaattga ttcatttatg aatggaaata taaatgtacg
     6901 gttaaatact tatgaagaag gtagtttatc aaagttattt ggttcaatag atgctatgtc
     6961 aacatctcta aacacacata tattgaaaga aaagcagaat aaagaatttc ttaaaaatac
     7021 aatttcagat atatcacatc aactaaaaac tccacttaca gcattgatga tgtataatca
     7081 aatattgcag gaagagagtc ataatagtga aattgttgag aattttgtgc agaagagtca
     7141 aaatgaatta gagcgtatag aatcattgat acaaaacttg ttaaagatta caaagataga
     7201 ttcaaagaca ataattctta acaaagctag tgttaacgta aaaaagttga ttactaaaat
     7261 tttatatagt tttgaaacta gagcagaaaa agaaggaaag agtatctcta taagaggtct
     7321 agaaaataca aacttgtttt gcgattatga atggatatca gaagctttaa gcaaccttat
     7381 aaaaaatgca ttagataata caaaagagaa cgataaaata atgatagaat gggttgaaac
     7441 acctataaca actattattt cagtgagtga taccggaaat ggaattcata ttgaagatat
     7501 acatcatata tttaaaagat tttataggag taagttttca aaaagtaatc aaggccttgg
     7561 attagggttg ccactagtta aatctatcat agaacagcac aatggaacca taactgtaga
     7621 aagtaatttt ttacaaggaa gtacatttac tctaagtttt ttaaagctta ctaatatgta
     7681 agataggata catcttacag taaggtgtat gaattattct tatattaatc atcagaaagg
     7741 agatagagca aatggatatt cttgtggtta ataatttatg taaaacatat ggaaatggat
     7801 atacaaaagt agaggcatta aaagatgtat catttacagt ttcaaaggga gagtttgtta
     7861 ctgtagttgg agaatctggc tcaggtaaga gtacattatt aaatctttta ggaggtcttg
     7921 atactccaac ctcaggaaaa atatttgttg atggtaaaga aatatgttca atgaaagaag
     7981 aaaaacagac tatttttcga cgtcgtaata taggttttat ctttcaatca tataatctta
     8041 tacccgaatt aactgtggaa caaaatataa tatttccttt actactagat tacaaaaaac
     8101 cagacactat ttatctagat gaagtattga caattttagg tcttaaagat agaaaaagtc
     8161 atcttccaaa tcaattatct ggtggtcagc aacaaagggt tgcaattgga agagcattga
     8221 ttacaaagcc atcaattata ttggcagatg agccaacagg aaatcttgac agtaaaaata
     8281 gcagtgatgt aatttcactt ttaaaagtga cagcagaaaa atataaccaa actattatta
     8341 tgataactca taatacaaat atagcttcta cagcagatag gatactacag gtttctgatg
     8401 gaatgcttaa agacctaggg gtgaatagag aatgagaagc tatttagaac tagtaccaca
     8461 atatgcaaag gtacataaga aaaaaaatag aactacaatt ttatgtattg tcattgcagt
     8521 atgtttagtt actgctattt ttggactagc agacatggct atacaatgtc aaaaagtaca
     8581 atttataaaa gatgatggaa attggcacat agtacttaaa aatcttaatg aagaagctat
     8641 atcagaaata agtagtagag tagatatagc tcactatggt agaggacaag tcattgataa
     8701 tggagagttt aaatcaaagg agattttgat acaaggttta gatgaagatt tagcaaaaca
     8761 attaggtcta gaaataataa aaggtcgtta tcctgttgtg gagaatgaga ctttaataga
     8821 tgtagatgca gttaaaagct ttaatctaaa agtaggagat tttatcaaaa taaaattagc
     8881 agatggtaga aataaaaatt ataagatagt aggtgaatat tcatcattat caagattaag
     8941 agcctcagat aagcatggat taatgctttc aatattaggt acacaagcta tcaaaaaatc
     9001 agaaacatat gattattatt atattacatt taaagacaag gttaatatta gaaaagctac
     9061 ttctgatatt aagaatacct tcaatttaag tgataaacaa atcggtaaaa atgaaaaatt
     9121 actttctatt ataggtcaag gtgactctga ttattctaaa ccactttact taacagcagg
     9181 aggacttttt atacttgtgt taatagcaag tattatcatg atatataata gctttaatat
     9241 gggtgtaata gagagaataa agttttttgg actattacgt tgcttgggag catcaaaact
     9301 ccaagtcaaa aaatttgttg ttttagaaag tttaattcta agtgtaaagg ctattccact
     9361 aggattgtta ttaggatgta ttgtaaccat tatatcctct atatttctca aatatgtgaa
     9421 tacagagtta tttggttcga tgccaatttt aaaggttagc tttattggta ttgtgtttgg
     9481 aataatagta ggatttttaa cagtaatatt atcagctatt gttccagcaa aaaaagcttc
     9541 tggggtgtct ccactaagtg ctatacgtgg taatctaatg ttcaaagaaa ttttaactag
     9601 tggaaaagca agtaaaattg ctaacgcagg aagttctaaa attgatgttt ctatgggaat
     9661 aaatcatgcc ttttcaagaa aaaaatcttt tatacttatg acttcttcat ttgctattag
     9721 tattgtattg tttttaggtt ttagtgtatt tatagacttt atgtatcagg cacttaaacc
     9781 tataaaacca gaagctgctc atatatctat tgttgacgct gactttaagt ctgttcttac
     9841 taaagacgat attaatgaaa taagtaatat caaaggaata aaaaaagtat acagtagaat
     9901 gatgacggat gtagaggcta catacaataa taaggaggca acatctcagc taatttctta
     9961 tgaaaaaaat caatttgact gggccaaaaa gtatctagta aaaggggaaa tcaatgaaga
    10021 taaattagag tcagaaaata tcggattggt agaagaaggt catgggttta atattggaga
    10081 taagatatat attaaaaatg gaaattctaa gaaagagata gaggtagcag gtatactttc
    10141 ttcaatttca tttgatgtta aagacaaata tattggaaat attataacat ctgaaaatac
    10201 ttttactagt ataacagata taaaagacta tataataatt gatactcaag ttgatgaaga
    10261 tgctcctgaa gatttaatcc aaaatataag aaatgttcta gatgataatt tagaggttcg
    10321 agataagcga caaggtaact tagaggctaa aaattcattt tacactatgg cagtttttgt
    10381 atatgggttt gtatttataa ttgcgattat aagtatgttt aatatcataa acagtatgaa
    10441 tataagcgtt acaagtagaa taaattacta tggtattatg cgtgcaatag gcatgtccaa
    10501 taagcaatta agaaaaatgg taatagtaga atcaagtaca tatgctgtaa gtggctgttt
    10561 attggggagt gtacttggat taatattaca tagatatata tttgtatcct tagtaacatt
    10621 aaaattccat atagactggc aaataccttt tgatttactg tttatcattg tagtaactat
    10681 gataataata actttgcttg cagtaagaaa accaattaaa aagatttgtg aattagacat
    10741 aatagaggta gtaaatgcac aataaatata agtagtaatt taaatagagg tagtaattta
    10801 aataaaaaat cgaagtaaat atgaaataga aaatatcttt cataatttac ttcgattttt
    10861 gtgttatata atttacttta gataagttcc atcttcatct tgataaatta agtctttctt
    10921 cataagtact ccaagagcac gtttaaaatt ttcttacttg aattaaataa gatagaaata
    10981 tctttaggat cagatttatc attgaatctc atatatccat ctgaaccttc taaatagctt
    11041 aaaatcttat tttctaaggt atcaagttca tcttttctgt ttcctctagg agaaagtcct
    11101 aatttaccat catcgtatat ttttataaca tgtaaatttt caagaacatc cccagctttt
    11161 aattctgtaa agtattcatt atgaaggatt acaccagcat atttattgtc aacacatatc
    11221 atagcagagt tgttggtttg gaatccatat acaactccat ttacaacatc tcctacattg
    11281 taagtatggt ctgtttctaa atatgaatct atgtctgtag tagcagctat tcttccgctt
    11341 ttatccaagt atatatagaa taaatatttt tcatctctaa acaatggata agtcttagct
    11401 ttaaaaggaa ctagtatgtc ttttgtaagt cccatatcta taaaagtacc aatatccgtg
    11461 ttatcaacta cttttagata cgtaacatct ccatttctaa ttatttctat agtattagaa
    11521 aaataatttt taaatagttt gtaaaatatt attgaatttt ttctctcgaa atatataatt
    11581 tagaatcttc tgatttattt ttatgctcga tttccttatt ttttttcata aatatatata
    11641 gaggagctat taacaacatt gcccctaatc ctattaaaac tctattttga gttataggtt
    11701 ttgaaatatc ttctgcccaa gcttgttgta acaaccataa gctacctaaa atagctacca
    11761 ttggtataac aggaccaaat ggaatcttaa aagaggcctt aacatctgtt ctttttctta
    11821 aaactattac tgataaacaa gttggtatgt actgagcaaa tcttgcaatt acactcatta
    11881 ctgcaagttg ttcaaaactt ccagttagca caagtggtat acaacaaatt aaagatatta
    11941 ttattgctac atatggagca ccatatttat ttgtttttcc tataaatgca ggaagagaac
    12001 cttcttctgc tagagaagaa ccacatttag gagttactat tgatgaacct atatttatac
    12061 caaatataga tattaatgtt gctacagata tgaaaaattt accataattg cctaaaaata
    12121 cacttgaagc atctgcaatt ggaatactgt tttcaaatag tctatctcca agtataccca
    12181 tacagacaat ttgaattaat atataaatta ttgcacatat aaatattgtg gttattaatg
    12241 cgactggaag atttttttta ggattttcca tttctccact tgccacaata aatgattcaa
    12301 agccggtaaa tgcgtaaaat actaatataa tggctggacc catactagag ttaactacat
    12361 ttcctgaagg aacaatattt acaaatttta taaagaatat tccaactatt ataaaaacta
    12421 ttaatggtac taatttagct atagttatta cattattcat tatctttgtg cttttaattc
    12481 caaataagct atttattgaa agtagtgtta cgagtattgc agctatataa cctttgtatt
    12541 cagtggcaga ttctggccaa aatgaaccta aagctgttgc aaatcctact gctagagtag
    12601 accatgatat aattctaata acccaagaca ttgtaccaac ttcaaatcct ataaaatctc
    12661 caaaagcttt tttggagtat agatatgctc ctccattctt atcaaacatg cttccaactt
    12721 ctgcaaaaca taaaagtatt gatagaacta agagtgtagc aaaaatgtat ataaacatac
    12781 tgttttgacc tgctagatta taaactttac ctggtagtaa gaatatacct gaacctatta
    12841 tgctattaat ccctaataat atcatactaa atagacctaa tttcttagct ttttccatat
    12901 taatttatct cctattcttt tattaattac tgtactaatt aaaatacaaa gtattcatta
    12961 catgcatcat aacacctatt ggtaaacaat cttcatctat attaaagcta gaggtatgaa
    13021 gaggtgaaat taagcccttt tcctcatttt tacatcctaa atggaagaat gctcctttac
    13081 aatgttctgt gtaaaaagaa aagtcttcac cacctaaaga cgggtttggt ctcaatataa
    13141 atttttcctc tccaagtaat tctttagtat ttgatataac tgtatctact aattcttttt
    13201 catttataac agcaggatag ttttcatcac ttacatgtaa agtcccaaca caaccaaatg
    13261 cagatgcagt gtctccaaca attttagcta ttttatcaat cataaagttt cttgttttgc
    13321 tatttaaggt tcttaaagtg ccttctagtt ttacatcttc acatattaca ttgtgtgcat
    13381 caccaccata tattttacct atagtcaaaa cagcagcatt atttggttct aagtttctac
    13441 ttattatagt ttgtaatgat gtaacaattt gtgaagctgt aactattgca tcaataccat
    13501 tttcaggata tgcaccatga gctcttttac ctttgatact tatttttata gtgtctacac
    13561 tagcatttaa tgtatcatat tttatttcga taaatcctgt ttcgatatgt ggcataacat
    13621 gaagtccgaa tatataatcg accttaggat tttctaaaca tccatcttca actaagaatt
    13681 ttgctcctcc aaaaccttct tctgctggtt gaaataagaa ttttacattt acattaagtt
    13741 tatcttttat tgaatgtaaa actttacatg ctccaagtag catggttgta tgtgcatcat
    13801 ggccacaagc atgcattttt ccagaatgta ttgatttata aggtatgttg ttttcttctt
    13861 caataggaag agcatccata tctgctctta tacaaatcgt tttatctgca ctttctttta
    13921 aaatatatgc cataattcca ttgtgttttg taaattccat ataatcaatt ccgatttctt
    13981 ttaaataaga aattaccttc tgtttagtaa gattttcttc aagagctaat tctggaattt
    14041 tatgtaattc tcttcttatg tttataagcc atggttttat agaattacaa ctttctatta
    14101 caaaatcttt tcctaattct ttggtttgat attttaattt caaagcctgt tgcattttta
    14161 ttcctccaat tgctttttat tgttttatta atataataag caattattat gccataattt
    14221 tcgatggaga actttgtttt ttataagaat attgaataaa tataatcatt tatctatatg
    14281 tatagtataa aaaatgattg catagtttca attttcagta aaaaatatta ttttgaagaa
    14341 aatatatttt atatgctagt ttatataaaa aaaataggaa ataaaaaaat tatcctattc
    14401 ctattaattc ctattattta tgtacaaaat aaattataat ttcagggtac ttgaaaaata
    14461 aaaaaaccta ttgaaggagt actttaatcc tgaatagatt tctttgtttg ataaattata
    14521 attttataga cctttatatt ttaatttatt gtaaaaatct tctccttttt gagttatttt
    14581 acttccatat cttcctgaac tacaaattat aagttcttct ttttttagat attcaaatat
    14641 ttttttaatt tttccttctg taatttgaag gttcttatcg agtagtgctt ttaaaattaa
    14701 tcctctacca ataccaacat ctgattcctt atttaaaatt agtatctcta atatattcaa
    14761 tatatcattc ttactatatt ttagttttaa tgatgtattt ttgttatctg aagaccttaa
    14821 gtttggaggt aaatctttct ctaatacaat atcttcacac ataatgttta aataggatgt
    14881 aacattttgg agttctctta tattaccttt ccacatatag ttttgtataa gtttttttgc
    14941 ttctggtgtg attactaatt tcttattaat taaatcttcc ataataatta atatgtcttc
    15001 ttttctttct cttagaggag gtatatttat tggaattgta tttaatcgat aatataaatc
    15061 ctctctaaat tggctattat caatcatttg ttctaaattc ttatttgtag cagatatgat
    15121 tctaacatct atattaatta cattgtgaga cccaacaggc attatctgct tttcttgaag
    15181 aactctaagt agttttgttt gtaattctaa aggcatatcg cctatttcat ctaagaatat
    15241 tgttccatta ttagcaagtt caaataatcc ttgttttcca tcttttagac ctccagtaaa
    15301 agttcccttg tcatatccga atagctggct ttctaataaa ttttcaggaa cggctgcaca
    15361 atttactgct ataaagggtt gattttttct atttgagttg ttatgtatag actgagctat
    15421 gagttcttta ccagttccac tttcacctct gataagtatg cttaagtcag atttagaaac
    15481 cttcttagct aaatctatac attcaaacat tttaggacta tttgttttta tatccttaaa
    15541 tgtatatttt gctatttgtc ctttttctct taatttttta gtgagatttt gttctaattt
    15601 ttttatgtat gttatttctt gtaaactata atatgtgccc attttttcat ctctattgta
    15661 tatgtttttt ttatttacat ttatatattt cttattgaat acgacaactt tatctagtat
    15721 ctctttctca ctcaataaaa cttttaaact atctacaaat atatcctcaa tgtattttcc
    15781 atatatatcc tcatttatgt ctaaaatatc ttttacttta ctattatatg tatttatttc
    15841 accatctttt gaagtaaata atataccatc ttttgataaa ttcaatattg tatctaattc
    15901 ttctattttt aaaaataatt ccttatattt atcttttata ccagtatcta aacttattat
    15961 ttcttctgag tatttaacta gattagattg tatttccttt gaatcaattt gtaataaatt
    16021 tattatttct ataaatgtag aaatatctat atatctgtga cctaaatcaa atatatctga
    16081 gataaagcta ggtacttttt ctggaactcc tggagttata gctattttta tatttttata
    16141 gttattatca ttcatatatg gaattggtct aatattagtc actccaattt tataaaataa
    16201 acttatagtt tctagagtag tttcatcaga atcatttacg attagaacat ttgtaccctg
    16261 tggtaaagat agtagattat aaattttatc ttccctaaaa gttcttctta ccacaatcac
    16321 ttttttctta tctagtatat tatttataat tttgtctaat ctttctactg acattactaa
    16381 tatcacatca tcatttataa tatcattatc atttatttca tttatgaagt atctattaat
    16441 atttatagaa tctccaaaaa ctaatttcaa attattttct aaaaagtcta ttaaatcttt
    16501 tctactatca tttaccagag ctactgattt tttcatttat ttctccttat ataataaata
    16561 gtttccaaca aaatagttgt ataaagcaat ataattttga taatttaaat ttatcaaata
    16621 aaaaagaaag tgtctataat gactttataa aagttgcatt aagacacttt ctttcttata
    16681 attaaaaatc ttgtcaccaa atccccctaa ttgttgctta aaacttaaac tgtatgtata
    16741 tttttcattt ctattcgatt aaattataat atacacccaa aaaaatttat tttaataaat
    16801 tctattgata atataatttt gtaaatatag aattatatta aaataaatta tatattaaaa
    16861 tatatatgta taagtttatt ctgcgtcagt agaatgaatt tgtcaagttt aatttagttg
    16921 taattttatc ttttattaaa aataatataa attaaaacat ataaataaaa tattttatac
    16981 aatatattgt aaaggaggta actttgatga aagcagaaaa aacaagtata tatccaatta
    17041 ttaaaaataa tttaaacaaa atatcaattg ttgaatataa aaagggtcaa agatttgtag
    17101 catcagataa agacttacaa gaagtgttct ttataataga gggagttgca ttagtggagt
    17161 gtactactag aggaggaaat aaatttcttg ttgacattgt acctgaaaat gaatttatag
    17221 gcaaaattag ttacatatat gaacataatt tgaaatgtga tatatttgca aagaccaata
    17281 taaaattatt tcgatttgaa aaaaatgtat ttgaagagtt ttatctcaaa ccagatttta
    17341 ttgcactatt tcacagaaaa tgtacaagaa gaatatatga attatataaa accagaatgg
    17401 taagagaact attttcttgc acagaagtta ttgcctattg tatatcaaat aaacaagaaa
    17461 ataatgtctg caatataaaa gctattcgta atttcagtga aatctattca attagtagaa
    17521 aaagtagata ccattctctg ctaaagttaa ctgaaaagga gatagtaaaa aaaatgggta
    17581 atacatatga aattttaaac tatgatgaat tacataaatt ggcatttgaa gtaaaagaat
    17641 ttttggaaga tgagtaaaaa ttgttactta atcaaaataa agtataataa tttctgtaaa
    17701 aaatagaaat agtctcactg aaaatcaaaa atactttagt tattttcaat gagactgttt
    17761 agaaatattg tatacttata atgtatagta taattattaa tcaatttcct ttactatatt
    17821 aatagcccat tttttagata atgctctagg aacaccaaat ataaacttaa ccacttcttc
    17881 actataagtg agcaaaacga gtacaaatat aggtgcacct ttaaatgcag ctataaaagt
    17941 tagaggaata gaagctaacc acatacatcc taattctaaa aatagagcat atttagtatc
    18001 tcctccactt cttaaaatac caattataac caatgtatta aaagatttaa gagccattag
    18061 tattcccatt ataaagaata tcttagttat atcagaagct aagctatcag aaacactaaa
    18121 catttttaat aataatggta tatttaaaat taaaataatt ccaagtatta aaccagctga
    18181 aaatacaagt atagaaaact ttttagcata ttcaatggct cttttaatat ggtcagctcc
    18241 aagttcattt ccaagcataa tagatgcacc agatgcaata catacagctg tcattatgaa
    18301 gaaattacct gtactggttg ctatctggct agctgctata gcagaagtac cagctcttgc
    18361 atatgcaaca gaatacagga cagttccaat tgcccataca gagtcattta caaatatagg
    18421 aaagcttttt gatgaaaaag attttataaa aattttatca atagctttta gattttttag
    18481 accaaacttt aatatatagt cttttttata aaggtaaaca taagtaatca ttaaaattaa
    18541 ttcacatatt ctagcaataa cagtagctag agcagcacct tttacaccca atgcaggaag
    18601 accgaagtta ccaaatataa atccataatt taaaataaca tttgttacaa gtgcaaatgc
    18661 actacaaatc atacctaact taggatttct aacacctctt gaaccagtgc taaatacagt
    18721 acttacagca attaatggat aactaaatac tgcaatacta aagtaatcta tacaaagttt
    18781 taccacctca gaatcatacg aaaatatgtg tataattggc tttggtgtta gtaaagcagg
    18841 aataacaaat acaaaactta aaacaattgc caatacacaa gtaagacctg tgacttttct
    18901 tatattactc acatccttct ttccataaaa ctgtgaaata aaaactccag cacctcctgt
    18961 gataccagat aaggacatat taaaaagaaa gaaaaattgg tttgcaactc caactgaagc
    19021 tacagatgtt tcccccaaac tacttatcat aattgtatct attacattta cagaagtaga
    19081 aattaagttc tgtatgataa taggtataca taaagataga agtattttat aaaatctttt
    19141 attttcgtct tttaaagaaa atagttcttg caaataatcc tctccttttt acataaattc
    19201 ttcccactca tcatatagag aggcaaggtt attttctaaa ttaatttttt cttggctaac
    19261 ttctttagct ttatctggat tagagtatac ttcttcttga cataaaagta tatctaattt
    19321 ttcaatttca atctctaact tttcaatttc tttttctata ttttgtcttt ttattctatt
    19381 tttcttttct atttctcttt gttctctctc ttttcttttt tcatctttta tttgagttct
    19441 agttttttct tctttttctt ctataatact catctcttgg atttgccttt ttttatctat
    19501 ataataatca taatttccca gatattcagt aattccattt tcatctaaaa ctaaaatttt
    19561 atcaacaaca gtatttagaa agtatctatc atgtgatatt gtaaatatag tcccatcata
    19621 attagttaat gcctcttcaa ggacttcctt agaatcaata tctaggtgat tagtaggctc
    19681 atctaataac aataagtttg catttgatag tataagttta agtatggcaa ctctagctct
    19741 ttctccacca ctcaatgtag aaatcttctt aaaaacttct tcatctacaa ataaaaatgc
    19801 ccctaacata tttctcaaag tagtttgagt aagatgagta ttattttccc aaatctcatc
    19861 aattattgtg ttatctaaat taagagtttt ttgttcctga tggaagtagg aaacatgtac
    19921 attagttcca aatttaatat tgccactaag aggttgtagt tcattagtta ttattttaaa
    19981 taatgtagat ttgccaacac catttgcacc tataagtgca actttttccc ctctatatat
    20041 atctaaatcc aagtctttaa aaagtattct ttctccataa cccatagata catctctaat
    20101 ttgaagaaca tcattaccac tctggacaga aggcgtaaat tgtatacgag cttttttcct
    20161 ataagcttct ggtttatcta aaacgtctac cttgtctaat gctttttctt tacttcttgc
    20221 acgctttagg tgtttttctc taccataagc ttttagtctt tcaattgatt cttcttgctt
    20281 ttttatttct ttttgttggt cttcaaattt cttaagctct agttcttttt ctattttaga
    20341 taactcaaca aatttagagt agttaccatt atatacttta agttttttgt tgtgaacttc
    20401 aaaaattcta tttacggatt ggtctaagaa atatctatca tgagatatta acatgacagt
    20461 ccctttatat tgttttaaaa atacttctaa ccattctatt gcttcagagt ctaagtggtt
    20521 agtaggttca tcaagtaaca atagagttgg tttcttaaga agtaattttc ctaaaagaac
    20581 tctagttttt tcaccaccag aaagtatgct tattggctta tccatatcat tgtcactaaa
    20641 tcctaatccc tttagaactc ctttggcttc agatttatat ccatatccat ttaaatctga
    20701 aaataattct agtttatgtg aatattcatc catgattttt tctataattg gagagtttgt
    20761 ttttgtactt tcttcagata ttttaacctc caattctctt aaataggatt ccatttctat
    20821 caaattttta aaaacttcta gtacttcttc caaaatagta ttatccgaat aaaaattggt
    20881 attttgttct aaatatccga tttcacaatc tttagaagtg taaatatctc cactatcata
    20941 tccataaatt cctgaaatta ttttaaataa agtagttttt ccagtaccat taacaccgat
    21001 tataccaatt ttatcgcctt catttactgt aaaactaata ttttctaata tagaatctat
    21061 accaaaactt ttatttaagt tattacatga caaaacaatc ataaatttct acctccttga
    21121 actatctaaa attataatgt tttgatataa tataatcaag gttatatgta ttagttttga
    21181 aaaagaaata ttttattgtg aatcaaacaa aaaagaggac acttttagga ggtgaagatg
    21241 ttgggaaata aaaatatatc aatggcagtt ataagaaggc tcccaaaata tcatagatat
    21301 cttggagact tattagatag ggatatacaa agaatatctt ctaaagaatt gagtgatata
    21361 atagggttta ccgcttctca aataagacaa gatttaaaca actttggtgg atttggacaa
    21421 caaggatatg gttataatgt agaagctctt catactgaga taggtaaaat tcttgggttg
    21481 gatcgaccat acaacgcagt tcttgtagga gcaggtaact taggacaagc tatagccaat
    21541 tatgcaggat ttagaaaagc tggattcgag ataaaagctt tatttgatgc aaatcctaga
    21601 atgataggtt taaagataag agagtttgaa gtattagatt cagatacttt agaagacttt
    21661 ataaaaaaca ataatataga tattgctgta ttatgtatac ctaaaaatgg agcacaagaa
    21721 gttattaata gagttgtaaa agctggaatc aaaggtgtat ggaattttgc acctttagat
    21781 ttagaagttc cgaaaggtgt tatagttgaa aatgtaaact taacagaaag tttatttacc
    21841 ttatcgtatt taatgaaaga aggaaagtag acaacttaaa catattaata atgagcagtt
    21901 gtgaagagta ttgagaaagt cagaagattt aatattaaat cctctggctt tttgaaatat
    21961 taggataaaa atttaaataa tgtatggaaa taaacaatat taaggagagt ggtttttgtg
    22021 gaggaattat ggaaaaaggc aattgaattt catggtcatg aatgtccagg gttagctata
    22081 ggatttaaag cagcacttgc agcaagagaa tatttaggat gtaaacagtc aggagatgag
    22141 gaaattgtat gtatttctga aaatgatgct tgtggaatag atggtataca agtcgtgcta
    22201 agttgcacaa tgggtaaagg aaatttacta cttaggatga ctgggaaatc agtatatcat
    22261 ttctttaata gggaaaatgg aaaatctata agaatatatg taaagtcaaa gccatttcaa
    22321 atggatagag aaggatacaa aaagtactta ttagaaagtg attttgaaga aatatttgag
    22381 attacagata ctaagttaag acttcctgaa aaagcaagaa tatttaaatc tcttaaatgt
    22441 gaagtgtgtg gtgaatttgc atctgagcaa tatataagga ttgaagaagg aaagaaagta
    22501 tgtcttgatt gctttaataa atatgaaaga ttttatgagg agtattaaaa ttataaatta
    22561 gattaaagtt aaaagtatta gatatgtgct aacagtattt taagatgaat taggtagcaa
    22621 cataataaag tatataaata atattaattg aatcatacat aattaaaaag aggctgatta
    22681 gtatttataa aataaaatca gtctctttat gaataacgaa ttattattct ggttgaggtg
    22741 catctacagg acaagctcct gcacaagaac cacagtctat acaagaacca gcatctataa
    22801 catatgcgtc gtctccagct gatatacagc taacagggca ttcagcctca caagcaccac
    22861 agcttataca agcgtcagta attttatatg ccattttgaa atcctccctt ttatatgtat
    22921 tgtaattcaa taacattata acaaatatta ttgaatataa caattaaatt aattctacaa
    22981 caaaaacttt attatgatat tcttgtttta aagttttaca ataaagttta atctgcttat
    23041 atttttattt attttaaaga agtttatttt aaaaataaaa ttaaatttaa aaagttatgt
    23101 attgattata tttaaaaatg ttatactcta aaaaagtata ttttatttaa aaatttatta
    23161 atacaaagga gatttactat gaaaaataaa ttagtttaca tatgtattat gagtctattg
    23221 ctatttgtag taggatgttc taataatcca aataaggaaa gtaccattaa aaaagactct
    23281 aagaataacc aaagccaagt taaagaagaa aaaagagaac ctgtgaaaaa agatataact
    23341 ataagtttcg ctggtgatgt aactatgggg aactataaag gttcatcata ttatggcagt
    23401 tttgaccatg aatttaaaag acaaggagaa gattacaatt attttcttaa aaatgtaaaa
    23461 cctgtatttg aaaaagatga cttaacagtg gttaatttag aaggtccact tactacagcg
    23521 tcaaatgcaa aagaaaaaaa atttgcattt aaaggaaagc ctggatatgt aaatatttta
    23581 aaatctggaa gtgtagaggc agtaagtatt gcaaataatc attcagaaga ttattttgaa
    23641 gaaggaatga aagatacaca gtttatattg gacgagaata aaataaatta ttttggatta
    23701 gggaaagatg ctgttgtaga tgtcaaagga attaaagtgg gtctattagg gtataatgga
    23761 ttatcaactg aatataatga aaaaaattta aaacaaatgg aagatgatat taagtcctta
    23821 aaaaagaaat cggatgttgt tgtagtgtac tttcattggg ggatagaatt agattattat
    23881 ccagataaaa aacaaaaaga ttttgctcat tatgctatag acaagggagc agatttagtt
    23941 atggggtctc acccacatgt gattcaagga atagaaaagt ataaaaataa gtatatagct
    24001 tatagtctag ggaatttttg ctttggagga aataagaatc cttctgatac agatagttat
    24061 atatatcaac aaacctttac tttttcagat aataaattaa cttcaattaa agagccaaat
    24121 ataataccaa cttcaataac atctagtaac tccagaaata attatcaacc aaaaatattg
    24181 gatggaagtg agaaggatag agttttaaat aaacttgaaa aaataagcaa agatttaaat
    24241 aaataaaatg taaaaaaaaa taaatatata tatttatttt aataatttat attttgttta
    24301 gggtatggta aatcgtggta ttaaataagt agattttaat agttaaatta tagtcaatta
    24361 taataaagct atttaatcta cttttttaat ataaaaatat aagggggaat ttgtaatggc
    24421 ttgtaacact tgtaaaatgt gcgaaagtgc agacaagaaa ttagaaagtt ttgtagcttc
    24481 aaaggatgtt gaaacagcat ttcatagaac agaagatcag aaagttaagt gtggttttgg
    24541 acttcagggg gtttgttgta gactctgttc aaatggacca tgtagagtaa ctcctaaatc
    24601 accaagaggt atatgtggag cagatgcaga cactatagta gcaagaaact ttttaagagc
    24661 agtagcatca ggagcagctt gttatttaca tgtggtagaa aatacagcta agaatttaaa
    24721 aaatgttgga ataactaaag gtgttgttaa aggagaaaaa acattaaatc aattagcaga
    24781 gatgtttgga atagaaagtg atgaaaagta tgataaatgt ataaaggttg cagacaaagt
    24841 tatcaacgat ttgtataaat caagagatga taaaatggaa ttagtagaaa aaatagctta
    24901 tgcacctaga gtgaaaaagt ggaaagagtt aggtataatg cctggtggtg caaagtcaga
    24961 agtttttgat gcaatagtaa aatcatcaac aaatttaaat agtgacccag tagacatgct
    25021 agttaattgt ttgaacttag gtatatcaac aggattatat ggtcttacac taactaatct
    25081 tttaaatgat gttatgttgg gagaaccagt tataagaatg gctcctgtag gatttaatgt
    25141 aatagaccca gactacataa atataatgat aacaggccat caacattcaa catttgcaaa
    25201 tttccaagat agattaaaag atgaagatgt tataaaatta gctcaatctg ttggtgcaaa
    25261 aggctttaag ctagtaggat gtacatgtgt tggtcaagat ttacaattaa gaggagaaca
    25321 ttatcaagaa gtatttgctg gacatgcagg taacaatttt acaagtgagg ctgttttatc
    25381 aactggagca atagatatag ttctttcaga atttaactgt actataccag ggcttgaacc
    25441 aatagcagat aaatataaag taaaaatggt ttgtttagat gatgttgcta aaaaagcgaa
    25501 tgcagaatac ataggtttag acagaagtaa attagatgaa cttagtaaca ctttaataga
    25561 aaaagcattg gagtcttata aggagagaag aggaagtatt gaaatagata taccaaaaga
    25621 ccatggattt gaacaatctt taactggtgt aagtgaaaag aacctgaaag cgtttttagg
    25681 agattcatgg aaacctctta ttaatttaat tgcagaagga aaaattaaag gtgttgcagc
    25741 tgttgtagga tgttcaaata tgacagcagg aggacatgat gtaaatactg ttgaacttac
    25801 taaagaattg attaaaaaag atataatagt actatctgca ggatgttcta ctggaggatt
    25861 agaaaatgtt ggtcttatgt cacctggagc agaagaatta gcaggagaaa acttaaaaga
    25921 agtatgtaag actttaggaa taccaccagt attaaacttt ggaccatgtc tagctatagg
    25981 aagactagaa atagtagcaa cagaattagc agctgaactt ggaattgacc taccacaatt
    26041 accattagtg ctttcagctc cacaatggtt ggaagaacaa gcattagctg atggagcgtt
    26101 tggtcttgcc cttggcttac ctcttcattt agctttacct ccatttataa caggaggaaa
    26161 attggtgaca gaagtattaa cagaaaaatt aaaagactta acaggaggac atgttatagt
    26221 gaatccagac cctaaatctt cagctaatca attagaagaa ataataatag atagaagaaa
    26281 aaatttaggg ttaaaggatg tggaatgcaa tgcatagaat ttttataaat aaagatttat
    26341 gtacaggatg taagagctgt gtactagcat gtatgctaaa acacaataaa gattatgaca
    26401 tgtacactct tgatttagaa aatatagata atgatagtag agggcatata gaattagata
    26461 gtaaacataa taatccagtt ccaattcttt gtagacactg tgatgaacct gaatgtgtat
    26521 tagcatgtat gagtggtgca atgcataaag atagtgaaag tggaatcgtt tcatatgatg
    26581 aagagaaatg tggttcatgt tatatgtgtg taatgtcttg tccatatgga ttattaaagc
    26641 cagatgatag aagcaagcag aacatactta aatgtgattt atgtaaagat gaggagtatc
    26701 ctagatgtgt agctaattgc ccaagtggag caattgaatt acagaaggag gaaaatgatg
    26761 aattatgtag tgttaggggc tagtgcagct ggtataaatg cagtaaaaac attaagagaa
    26821 ttagataaag attcaaatat agtagtaatt tctaaagatg aaaacgtata ttcaagatgt
    26881 atgttgcatc acgttatatc tgaacacaga attttaaaac aaataaattt tgttgatgaa
    26941 gattttatgg agcaaaataa tgtaaaatgg attgcaggta agactgttaa aggtatagac
    27001 ataaataaaa aggtagttca gacagaagac attactgtaa attatgataa acttttaata
    27061 gctacaggtg catcttctgc tattcctcct ataaaaaatt taagagatgg aaattttgta
    27121 tattctgtga gaaacataga tgatatttat aaaataaaag aaaaagcaca aaattctaaa
    27181 aatgtagtta taataggtgc tggtttagtt ggtatagatg cattagtggg attatttaaa
    27241 tatgagcagt taaatatttc tgtagctttt atggaaaagt acattttaga tagacaattg
    27301 gatgaatata cagcatcagt gtatgaaaat aagttcaaag aaaaaggtgt aaaattttac
    27361 ccaagtgcat caatacaaga aattgtattg gataacagta aaaatgttac aggtgttgca
    27421 ttttcaaatg gtgaagtttt agatgcagac atggtaattg ttgctacagg ggttaaacca
    27481 aatgctgact ttttagatgg aacaggaata gaatatgata gaggtataat aatagatgat
    27541 atgtgccaaa caacacaaaa agacatatat gcagcaggag atgttgtagg taaaaatgct
    27601 atttggcctc tggcagtaaa gcaaggaatt gtagctgcct ataatatggt tggaaaagat
    27661 aagaagatag aagatgaatt tgcttttaaa aacagtatga atttcatgga tataccaact
    27721 atttctatag gaatgaatac acctgtagat gatagctata aagtgctaac tagacatgga
    27781 attaatgatt ataaaaagtt tgtttttaaa gataatgtaa tctatggagc agttatacaa
    27841 ggagatattt catatgtagg tgtattaact tatttaataa aaaataaagt tgaaatatat
    27901 gatttagaaa ataggatatt tgatatatgt tatgcagact tttttaatat aaaagaaaat
    27961 ggagaatttt gttatagtgt atagtatata cgtggagtaa ggtttataaa tacagtaaat
    28021 caataaatag agttattcta aaataagaaa aatgacaaat cttatttaga aatagctcta
    28081 ttttttgtaa ttaaatttaa attatattca atttgtaaaa tattattttg aacaattata
    28141 catatactct ctagttagag gtaaatcatt ttttatacct ttagtgaaaa gtatttgatg
    28201 tatatctata ataccagtgt tgaaagcagc agcacaagaa caaaggtata aatcccacat
    28261 tcttataaac ttatcatcaa acatttcttt aatctttgga agattctcag agaaattttt
    28321 ttgccagtat agtaaggttt ttacataatg taatcttaga ctttctacgt ctatagtatg
    28381 atatttgtaa tcactacaaa tatgtatcat ttctcttagg ctaggaataa ctcctcctgg
    28441 gaaaatatat ttttttatcc aagggtctcc ataagattcc tgcaatccac ttatatagtg
    28501 aagtaaaaac aatccaccat cttttaaaac agcatttacg tttttaatga aaagttcata
    28561 gttttctcta ccaacatgtt caagcatccc aacgcttaca attctatcaa acataaggtc
    28621 tgattttttt aattctctat agtccataag tcttacttca agatagtctt gaaggttctc
    28681 ttctttaatt cttgcgttaa attccttaaa ttgctcttcg ctaagtgtaa ttccaacgcc
    28741 gtgaatttta tatttttttg cagcttctat tagtaaaaat ccccaaccac aaccaatatc
    28801 gagaaggctc ataccttcct ctaaatttag tttagttaat atgtggtgaa ctttattgac
    28861 ttgagcatca taaagagtat cattatcatt tctaaagtat gcacaagaat aactaagtgt
    28921 cttatctaac cataagctat aaaaatcgtt gccaatgtca tagtgggcat gtatttcttt
    28981 cttttgatgt ctcattgaat ttgatgagtg caatagatgt tttacagctg aattatcaat
    29041 attgaatttg tctatttgtt ttaaaagtag atttaaagtt aagaataaat ctccctcaac
    29101 ttcaatgtct ctatttatgt aggcttctcc aagtgctaaa gatgtacttt ttaatagttc
    29161 agacttgcta atatcattat ttactataac tttgaactga ggggagccct ctccaattag
    29221 aaattcttcc tcatctttaa gcctaactag aaatggtgtt tcaccaaatt tctctaaata
    29281 gtcttttaaa aaattttttg taatattcat attaccagct ccttctaatg taaatccagt
    29341 aagtttccct gcttaaaata tattatagtc ctttttttaa aaaagtaaaa ttttttcaat
    29401 aaatttttta tttaaaggaa atttattttt tataaagaaa tttcatgttg tagtatattt
    29461 tttgcttata aattttggta ctggatataa tattaaactg ttaatgatat aataaattta
    29521 atctataaag taaataaaat tttgtaataa atagttaaag ctattttata aggagatata
    29581 tgatggaagt atatgctttg gttgggtcaa gtggcacagg gaagagcttt aaggctttag
    29641 agttcgcata tgaaaatgat atagaatata taattgatga tgggatttta atatacaaaa
    29701 acaaggtttt agctgggata tcggcaaaac aagcaaatac tactatagaa gcagttaaaa
    29761 gggctatttt ttataatctg gagcatagac aagaagttag agaagcaatt aaaaaagaaa
    29821 atataagaaa aattcttatt attgggacat caaaaaaaat ggttaatcaa attgtagaga
    29881 gattgtcaat tggaagggtt tgcaagttta taaatataca agatataagt actaaatatg
    29941 aaatagaaat agcaaaacaa gctagaaaag aaggaaatca tgtaattcct gttccagcag
    30001 ttgagataaa aagtatggca agtggtctta gtataaattc tttgaagaga ctttttagaa
    30061 aaggaagtaa taggaatatg gtagttttag aaaaaacaat tataagacca acttttagtt
    30121 atataggaaa gttttatatt agtgctgatg taattaaaca gattattgaa tatgaagtat
    30181 acaactttgg aagcattgat agaataaata aaatcaatat agagaattgc aataatttta
    30241 tgaatatttt tgtaagtata aatatcaatg atttagaaac tataaaaaaa attgaagaca
    30301 tacaacagac aataaaaaag tctattgaga aaatgacttt agttaatgta caaaaaatag
    30361 atattaacat tcataaaatt aaaaaaataa acttcctcca atgttaaaaa ataaactgag
    30421 aaaatgatat actaatttgc aataaagtgt gctataatta aactgtaaat ttaggaaatg
    30481 gttttttcta aatggagtat acataattat aacgtattta taagggggct ttcaaatgtc
    30541 aggaaaagat gtaaatgtct tcgagatggc gcaatctcaa gtaaaaaatg catgtgataa
    30601 attaggtatg gaaccagcag tttatgaatt attaaaagaa cctatgagag ttatagaggt
    30661 ttcaattcca gtaaaaatgg atgatggttc tataaaaact tttaaaggat ttagatcaca
    30721 acataatgat gcagtagggc caacaaaagg tggaataaga ttccatcaaa atgtttcaag
    30781 agacgaagta aaagctttat ctatatggat gactttcaag tgttctgtaa caggtatacc
    30841 atatggtgga ggtaaaggtg gaataatagt agatccatca actttatctc aaggtgaatt
    30901 agaaagatta agtagaggat acatagatgg aatatataaa ttaataggtg agaaagttga
    30961 cgttcctgca ccagatgtaa atactaatgg tcaaataatg tcttggatgg ttgatgagta
    31021 caataaatta actggacaaa gttctatagg tgttataact ggtaagccag ttgaatttgg
    31081 tggttcttta ggaagaacag ctgctactgg atttggtgtt gctgttactg caagagaagc
    31141 tgctgctaaa ttaggaatag atatgaaaaa agctaaaata gctgttcaag gtataggaaa
    31201 cgttggttct tatacagttc ttaactgtga aaaacttggt ggtactgttg tagctatggc
    31261 tgaatggtgt aaatcagaag gttcttatgc tatatacaat gaaaatggtt tagatggtca
    31321 agctatgtta gattatatga aagaacatgg taacttatta aacttcccag gagctaagag
    31381 aatatcttta gaagagttct gggcttcaga tgttgatata gtaataccag ctgcattaga
    31441 aaactctata actaaagaag ttgctgaatc tataaaagct aaattagttt gtgaggctgc
    31501 taatggacca actactccag aggctgatga agtatttgct gaaagaggaa tagttcttac
    31561 tccagatata ttaactaatg ctggtggagt tacagtttct tacttcgagt gggtacaaaa
    31621 cttatatgga tactactggt cagaagaaga agtagagcaa aaagaagaaa tagctatggt
    31681 taaagcattt gaatctattt ggaaaatcaa agaagagtac aatgttacaa tgagagaagc
    31741 tgcttacatg cattcaatta agaaagttgc tgaagctatg aaattaagag gatggtacta
    31801 agatttactc ttaataaata ataggatata attatttaag atataaaggg gctgtacata
    31861 gtacagccct taaattatgt ggcttacaat gaagtaagct atttttgttt taacttataa
    31921 aaaacttgat aaattatgta atttagaatg tattttttac caccacatga ttacaaatta
    31981 gaagagttag attagatttt tagacatgaa cttatgcatt ttaaaagcaa agaccttaat
    32041 ttaaagtatc tagtattatt tttaaaaata gtatattggt ttaatccatt tatatatata
    32101 atggaaaaat atatggattt ggattgtgaa ctttattgtg atgagagagt tttaaaaaat
    32161 tgtactgtac aacaaaagca agaatatgct ctaactattg taaattcaat gaaaagaagt
    32221 acaaattttt caaataaatt tgtagctgga ttaaataaac aatctgatat tagaaaaaga
    32281 gtaataaaca tgttcagtga aaaacataaa aatggtatct taagggcttt gattataagc
    32341 ttgttttctt ctattacatt ttttaaattc gattcaacta gtattattga agagaatgat
    32401 ttcttagaga ggtcaagata tacgtttgaa ggaaggcaag aagacatgtt tgtaacaata
    32461 gattttatat atgcagatgt acctataaaa cttagaaaag agcatgaaga aaactgtaga
    32521 gtcaatggaa tagtaccaaa agattcagat tcaatagaaa ttattcctag attttataaa
    32581 gattgtatgg atttaaaaaa ataagttaga cttaatattg atgttgatat tatgaatttt
    32641 ttatatttaa gcaattgaaa attttattat agattcaatt ttatatgtgt ttaagtatga
    32701 aatttataga tagttgaaat aattaaatat gattgatgca taggaatcat tactaagcta
    32761 taattaatta taagggagtt taaataaatt atgagttaca caattataaa atgataaaaa
    32821 atagttatct gttacaaaaa atgtatcttt ttaattaata aagataatat gaaaacttaa
    32881 aaggcaaata aacttaaaca taaaatactc ttaaataaga taggagaaaa atgtatgtct
    32941 aactttattc taaatgggat ttttagaaca gttatagtaa gtagtctaag cattcttatg
    33001 atattgattt tcaagaaaaa tgtatttaaa agatttagca aaaaatttaa ttattatata
    33061 tggatgatag ttgttattaa attattttta ccatttacat attatacttt tacaataaat
    33121 atcttgagaa gtaaaaaaca cattaatatt aataacataa atttagaggg atttaataat
    33181 gtttcaacta taagtaataa tattatattg tacacttgga ttataactgt agtagtttat
    33241 ttaatttaca ctatatttaa atatataaaa cttaaaaatt taataaatga cttatcttat
    33301 gatgttgatg atggagagat tgtaaatctt tataaaaata tattagaaga atttaatata
    33361 acaaaagata taaaactcaa atactcttat gaagttgaaa caccagcatt ttttaattca
    33421 tgtgtgcttt tgccaccaca tgagtataaa ttgaaagagt tagactggat ttttagacat
    33481 gagcttatgc attttaagag tagggacctt tatttaaaat atgtaatcct gtttttaaaa
    33541 acagtatatt ggtttaatcc atttatatat ataatggata aacatataga tttagattgt
    33601 gaactttatt gtgatgaaag agttttaaaa aatcgaaatt cagaggaaaa aaaggattat
    33661 gctttaacaa ttctaaatgc aatgagaaaa ggttcaaata cttcaaataa atttatagct
    33721 ggactccata agcaatctga tattaaaaag agagttatga atatgtttaa tgaaaagtac
    33781 aagaatggta tattaatggc attaacttta tgtttattat cttctattac ttttttgaag
    33841 gttaattcaa cgagtattgt taatcttaat atattgccaa aaggaatgga agaaaaagat
    33901 gttactaata gtgcaattgt tacaatgata gaatttacat atgcagaagc tcctaaaagt
    33961 atgagagaag aacataaaat aaattgtgaa ttcttaggtt taatacctaa agactctgat
    34021 aaaataggtg ttggtataga atattatgac agtctattga atgattaaat aaatattatt
    34081 ttaacagata ttaattataa agttttgaat agtaatttgt tgagaaataa atatatcctt
    34141 ataaaaatag atacttatat accaagaata aaaaatagtc aagatagtac acaaggatat
    34201 acttataaag aactcaaata agtgaaataa attattaatt ataaggttta taattttaaa
    34261 aaattagata aattcaggtg taaaatacta taaaacacaa ttcggaaaag tgtatgttga
    34321 acttcattta aaatggaatt tcaaagttgc tatagtaagt agtttaagca ttcttcttat
    34381 attaatcttt gagaataatg tatttaaaaa agttagtaaa aaatttaact attgtatatt
    34441 aatgatagtt gctattgata tattatctaa aaaaattaag tatgaaaaga ttactgctag
    34501 gacaatcttt tcatacttaa tttttaatat ttatattatc caaaattttc atctttttaa
    34561 cttagaattt gagaatcact attaggaaat aggctttgat ttatgtaggg ttaaaaattt
    34621 cacagaatat ctaactttat actaaatcca tcaaaaaata tacgccatat aaaagcgcat
    34681 aaaaaaacac ataaaacaat atttatgcgc actttaacct cgaatggtac aaaattcttt
    34741 acttttacag acccatatta tataattaag taaataatgt atatttaggt gacatattgg
    34801 ataagctaat ttatttattt tattaatata atgatactat aaaagttata taaagtggtt
    34861 tacaaaaaag ttacagatag agcttttatt aatgtattgt gtattagtat tttatcctta
    34921 ggtacacttc acctacaaaa tagaatcata agataattat gggaaaattt taggaggttt
    34981 atcgtgaaga aaaagatatt aataccagta tttgcatcag ttatggcatt atcagtaagt
    35041 tcaattgtaa atgcagatga agtaaatgat tcatctcaaa ataaggatga taaaacaaat
    35101 actgaattaa atttaggtga atataaagaa gtaaaatata aagttgcaaa aataaaagat
    35161 ggagtagcta taaagataag agaagaaggt caagttcaaa acatagctta ttctggagat
    35221 gaatttacgg ttttaggaac tcaaggagaa tgggttaagg ttaaagttga agatggcgaa
    35281 ggttggttag ctactagata tgtagatata tctgaaggtg taggatatac taacgctgat
    35341 aaagtaaact taagaaaaga taagagtgaa agttcagaag taattgaaga gctggaaaaa
    35401 ggaagttctt tattggtttt ggaagataat ggagattggt taaaagttaa agatggggaa
    35461 acagaaggat atgtaaaatc atcttatata tctgataaag ctcctgtaat agaagagcca
    35521 caagtaaacc caagtattga ccaaaatgta gattctacaa ataataatca acaaaacaat
    35581 gcaaatacta atcaacaaaa taataattca aatgtgccaa cagctaactc taatgcagtt
    35641 caagctgtac ttaacttggc atattctaag caaggttgtc catatgtttg gggagcagaa
    35701 ggaccaaaca cttttgactg ttctggattt acacaatatg tgtatagaaa tgcagtagga
    35761 aagaatatac caagaacatc taaagcacaa tctaaatatg gacaaactgt aagtaaagca
    35821 aatttacaac caggagactt agtattcttc acaactaatg gttctggttc tgttagtcat
    35881 gttggaatat atgtaggtgg gggtaatatg atacattcac catcaacagg aaaaacagtt
    35941 agtgtaacta gtataaattc atcatactat acagcaagat ttgttacagc aaaaagaata
    36001 ttataatcgg tttgtaatat gacaaattga taaatacata aatatatata aacgctctat
    36061 attatattta atttaatcat ggaaacaaaa aatgattata ttttaaatgt actatagagc
    36121 gtttttgtat cactttaaat ctaatcaaga ttcaagttaa tatgactgtt aaataggagc
    36181 cttttcatat gatgattatt tgcgcaatcc cttgacagga tagggcaaag gtggtaagct
    36241 actaacagta caaaaatact tttaatttta gttcagagag gctaaaaaag gaggacgaaa
    36301 gatgttaaaa tcaagaaatt taatccagcc agaagacttt tcaatagaag aaatagatga
    36361 aatattagaa ttagctcaaa aaataattga caatccgtca aaatattctc gtatatgtga
    36421 aggaaaacta ttagctacat tattttatga accatcaaca agaacaagat taagctttga
    36481 atctgctatg aacagattag gaggacgtgt agtaggcttt tcagagccaa attcatcctc
    36541 tgcatcaaaa ggtgaaactc taggagatac aatgaggata gtatctggtt atgttgatat
    36601 aatagctatg agacatcctc aatcaggtgc agcttcagaa gcagctagat atacggaagt
    36661 gccatttata aatgcaggag acggcaaaaa ccagcatcca actcaaacac ttacagactt
    36721 acttactata aaatcattaa aaggaacttt agaaagccat acaataggat tatgtggtga
    36781 tttaaaatat ggaagaactg tgcattcttt ggttaaggct atggcaagat ataaaaatac
    36841 aaagtttgta tttatagcgc ctgaagagtt aaaaatgcca gattatataa aagaagctat
    36901 aaagggacat gcatattatg aaactaataa tttggatgat gttataggaa gcttggatgt
    36961 tttatatatg actagagttc aacaagaaag atttgaagat aaatcagagt atgaaagact
    37021 taaaaactat tatattttaa ataaagctaa attagaaaag gcatctaaag atatgttagt
    37081 aatgcatcca ttaccaagag taaatgaaat agacatagat gtagatagtg atgatagagc
    37141 tgtatatttt aaacaagcta aatatggaat gtatgttaga atggctttaa taataaaact
    37201 tttaggtata aatgaagact aatagttatc atataatagt aaaacaaagg agattttggg
    37261 atgtataaaa ttctggaaaa tatatatata ggcgaagata tgtatagaat gaaagtaaaa
    37321 ggtaattttg aaggtaaaat gggacaattc tatatgttaa gagcatggga tacttatcca
    37381 gtactttcaa gacctataag tatacatgat atagatgaag aagggataac ttttctttat
    37441 aaagtagtag gagaaggaac tcaaattttg agtaacctaa aggtaaatga taatataaaa
    37501 ttagaaggcc cttatggtaa tggatatgct aaggttgatg gaaaggtagc tctagtagga
    37561 ggaggaatcg gtgtagctcc actatatttg gttgctaaaa atataaaaaa ttgtgatgca
    37621 tatcttgggt ttagagaaga tgttatatta gaagatgaat ataaacaagt atgtaataaa
    37681 gtctatacaa cagtaggaaa tacttttgta acagatataa ttgatgttga gaaatatgat
    37741 tatatattaa catgtggtcc aactccaatg atggaaaaat tagttaagat ggtagaaggt
    37801 actaaaacga gaattatggt atctcttgaa aaccatatgg cttgtggagt aggtgcctgt
    37861 ttagtatgta cgtgtaaaac taatggagga aataaaaaga cttgtaaaga tggtccagtg
    37921 ttctggggag aggacgtgat ttttaatggg taatttaagt gtgaaatttg gaagtgtaga
    37981 atttaaaaat ccagtaataa tggcgtctgg aacttttgga tttggaaaag aatataatga
    38041 gatttatgat atacaaaaac ttggtggtat aagtagcaag ggtcttactt taaataaaaa
    38101 acctggtaac aatggtatga gagttcatga gacatcatcc ggtatgatga atagtgttgg
    38161 gcttgaaaac cctggagttc aaggatttat agactatgaa ttaccttttt ttagtaaact
    38221 agacttagtc agaatagcta atgttggagg tgggacatta gaagactact tattaggggt
    38281 tcaaatgtta aatgacaagc ctatagacat tattgaatta aatatatctt gcccaaatgt
    38341 caaagctggt ggaatggctt ttggtataaa aaatgaagtg gcaagagaag ttgttcgtga
    38401 ggtaagaaac ataacgaaac tgcctttagt aataaaatta tcacccaatg cagaagatat
    38461 tgtaggaatg gcaaaagttt gtgaagaaga aggtgctgat ggagtttcat tagttaatac
    38521 ttttaaagca atggcaattg atataaaaaa tagaagacca gtatttgaaa atgtatatgc
    38581 tgggttatct ggaccagcta taaaacctat agctttgaga atggtacatg aagtgtgtaa
    38641 aaatgtaaat atacctgtaa tgggaatggg cggaataact aaagccacag atgctataga
    38701 gtttataatg gcaggagcta cttgtatcca agttggaact gcaaatttta tgaatcctag
    38761 aataggtatt gaaataatag atggaattaa tgaatttatg gatagagaag gaataaaaag
    38821 tttagacgaa ataagaggaa ttatataagg tagaataaat agtattttaa agataaaaaa
    38881 tatagattaa ataaacaata attttataac attaacatgg aggaaaaata atatgagtaa
    38941 agtagatgta gtggatatat taaagaaaag tgatgcattg ttggagggac attttttatt
    39001 atcttcagga aaacacagta atagatacgt acaatgtgca aaagtattaa gatttccaga
    39061 atatgctgct gaggtattaa gtacagttgt tgaacaaata aaagacttag atatagactt
    39121 agtagtagga ccagctatgg gtggagtaat agtttcttat gagttaggaa gacaattagg
    39181 aaaagaagct gtatttactg agagaaaaga caatacaatg gagttaagaa gaggatttga
    39241 agttaaaaaa ggagcaaaga taataattgc tgaagacgtt gtaactactg gtaaatcaac
    39301 tatggagaca aaaagagtat tagaagcctt aggtggagaa gttgtaggtg ttgcatgtat
    39361 agcagataga actaatcatg atataggtat gcctatatat agtgctataa aacttgatat
    39421 tcaagtttat gaatctgatg agtgtccttt atgtaaggaa ggaaaattac cagttgttaa
    39481 gcctggaagt agagagttca aggaattagg gatgtaataa aaacttaatt atttatagtg
    39541 ttacttaaaa aatgtaaatt ttttagagta aaaatttgta atataacata taacttaaaa
    39601 ataaaaagca gttagcctta taaatgaagg ttagctgttt ttttgttaaa aatatattta
    39661 caaaataaga gatagtagca gtacaatata agtataaggt aaaagtatta tatattaggg
    39721 aggggtaagt atgaaaaatc aattaaatga aaatcataaa aaggttgtat tttttggagt
    39781 aggtgctgta ggagctactt ttgcagaaca attttttaac tctaaatatg attttaaaat
    39841 tctttgtgat aatgaaagaa agaaaagata tttagaagaa ggatttataa taaatggaaa
    39901 aaggtatgat tttgattatg taactaaaga tgagtataaa caagaggctg attttataat
    39961 tataggtcta aaatataata atttaaaaga aaatataaaa gaattagatg gattagttgg
    40021 aaaaaataca gttataatgt ctctgctaaa tggagttgat agcgaagaga taataggaga
    40081 aagatttgga attgaaaaaa tggtatattc atatgttacc aatatagatg caaagaaaat
    40141 caataataat attatacaca ctactaatgg gataattgta tttggtaaca aagataatag
    40201 tgaagataga aaaactaata taataaccga agtctttgat gatgtaaata tagaatatac
    40261 tttatcaaaa gatattcaac gagatatgtg gtggaagtac atggttaata ttggtgtaaa
    40321 tcaaacttca gctatacttg gtgcacctta tggagttttt cagagttctg agcatttaag
    40381 agaattagca aaatctgcaa tgagggaagt tgttgctata gcacaagcaa aagacatatc
    40441 tcttacagaa gatgatgtgg aacattcatt acatagaata ctagaacatt caaaagaagg
    40501 aagaacatca atgcttcaag atgtggaagc tcatagactt acagaagtag atatgttttc
    40561 taagaatatc tgcaaacttg gaaaaaaata taacatacct actcctataa atcagacttt
    40621 cttttatatg ataaaagtaa ttgaaagtag attttaaagg gtctttgtaa gaaatattga
    40681 taattattga ttttaaattt tattaatgtt atatactatt taagttacta aatattttta
    40741 actcttcaat gaaaatagtt gctgcttttg ataaagttat atcttttgga aatatatatg
    40801 agaaatgtct gttgtagctg cttccaagct ctatgacaga cagctcattg tttagaacag
    40861 gtaagcttgt cactagatta gagactattg taattcctaa attatttcta acagattctt
    40921 tgacagcata attacttcca aaaaccatca tactttttgg aataatttct ttaacactta
    40981 aaaacatatc taaataatct ctggttccag aaccatcctc cctgactatc catttttggt
    41041 tttgaagttt atcaaaacta aaatctttta ataaatgact cttgtatgga agtgctaaaa
    41101 ccatcttatc ttcaaaaaaa tattcttgaa taaatgaagg ggaagagcaa gtgccttcaa
    41161 taagaccaat gtctaaaata taatccttaa catgagaaga tacgattgat gtatttttta
    41221 taaaaacttc tacatctatg tcaggatact ttttagaaaa taatgctaga aaatttggta
    41281 aaatatactc tccaatagtt aaacttgcac caatctttaa gtgaccagtt atagcatctg
    41341 aaacttggct tacatcatga taagtaatat ttaaaagatt taatatttct ttagctcttt
    41401 tgtacaagat ttgtccactt tctgttataa aaatggtttt ttgtttaata gacctgttta
    41461 taagcacaac tttaaaataa ttttctagat tttttatgtg tttacttaca cttggttgtg
    41521 atagatttaa atattcccca gctttagtaa agtttttgta ttcaacaaca gctacaaatg
    41581 tttttaattc ttcaaacaat tttttgtctc ctttacctaa tgaaatttta cattttttat
    41641 atactttcta cagataatta tactatatat aataaccatt aaaaacatta atcattacga
    41701 tattatatat ttattttact tatggttatt acaattatat actattgcta tgaagaaaac
    41761 tatattaatt ataaggtagg tatattatgt taaagaaaaa aagcagtttg acattaaaaa
    41821 ctataaggga aatattacca ggactgtttg tatcagtatt agtaggttat attagtatat
    41881 ttatttctat tttaattcct aaggtagggg cagcatcaat ttctatattt ttaggtatgt
    41941 ttgtaggaaa cctattttta aatcaaaagg tatttcaaaa aggttataaa ttttcagaga
    42001 cagatttgtt atcatattca atagtactat taggagcaac actcagtgta tctaccttaa
    42061 tagacttaaa agtttcagga attttattta taatattgca aatgacaata acaataatag
    42121 ctgcacttta tataggtaaa aaactaggat ttgaagaaaa ctttagattt ctaatggcaa
    42181 gtggaaatgc agtatgtggt tcttctgcaa taggagcaac agttccagtg gttaatgcga
    42241 cagataaaga aaagggaatt gcagtaacta ttgtaaatgt tactggtata tttcttatgt
    42301 ttttacttcc aataatatct caatttttat atagccatga acttgtaaaa acttcagcaa
    42361 tgataggtgg aactttgcaa tcaattggtc aggttgtagc aagtggagca attgttggag
    42421 aaaatgtaaa agatttggct actattttta agatagtaag agtaatattt ctagttgttg
    42481 ttgtattagt atttggacat atgaaaaatc aatctaatag ggaaattctt gaagaagaaa
    42541 aggatgagat aaaaaagaaa aaagtgacta taccatggta tgtaattgga ttctttataa
    42601 cttgtgcact tttttcaatg aacattatac caaaagaagt atctgtgttg tgcaaagaaa
    42661 taagtaacaa actagaaata atagctttag cagcaattgg attaaaggtt aatgtaaaag
    42721 atttagtgaa acaagggaaa gaagtttctt tatatggttt atttgtaggt atagtacaag
    42781 ttgtatcagc tgtagtttta ataaaaatat ttatatagca taaaaatagt atttgtaata
    42841 ttaatttgat taactaaaat aatatgatac taataattta taatataaat aaaaaatgaa
    42901 tttcgataag tttaagtggg tataaactta tagaaattca ttttttattt aaggtaaaaa
    42961 tttaaagtaa aatattattt tacataataa taaccttata aattttgaaa ttacttatct
    43021 ttgtgttaaa ataagtaaaa tgcacatatt agagctaagt ttttaagtaa ataaacaaaa
    43081 tgaaaatata aatattaagg agatttggta tatgaatgtt tatgaaaaag gtaatggagt
    43141 tatactagaa ggagtaacag attttgaccc agtacatata tttgagtgtg gtcaatgttt
    43201 tagatggcac aaacaagaag atggctcata cactggagtt gcaaagggaa gaatattaaa
    43261 tgtcaaaaaa gagaatgata aaatatattt aaataatact aatttaaagg agtttaacag
    43321 catttggtat aattactttg atttaggaac tgattataca gaaataaaga ataagctaaa
    43381 aaatatggat gaatatttaa ataaggctac tgaatttgga tggggaataa gaatattaag
    43441 acaagatgga tgggaaatgc ttatatcatt tataatttcc tctaataata ggattcctat
    43501 gatacaaaga gcgatagaaa atttatcaag aaagtttggt aagtatatag gtgaatatga
    43561 aggtaatgaa tactatgcat tcccaacacc agaagaacta aataaggcct cacaagagga
    43621 aataagagca tgtcaaacag gttttagaga taagtacata aaaagtacta cacaggcagt
    43681 tatagagaat aatgatgagg tatctgaata tacaaattta agtacagagg attgtagaaa
    43741 agagctttta aaatttaatg gagtaggacc aaaagtatgt gattgtattg cattatttgg
    43801 tatgcaaaaa tatgattctt ttccagttga tgtttgggtt aagagagtta tgcaagaatt
    43861 ttatatagat gaagacatga gtttacctaa aatgagaact tatggaatcg ataaatttaa
    43921 agaaatgtct ggatttgctc aacagtactt attttactat gcaagagaac tcggtatagg
    43981 aaaataaatt aagggggaga aattatggga gtaataggaa caatatttct gttctattta
    44041 attatatcat atctagctgg agccataatt tctgtgatta tattgcttga aaatagagac
    44101 cctgcaaaaa caatgtcttg gctattgatg tttattatat ttccaggtgt aggtttaatg
    44161 atatatgcta tttcaggtag aaatattaga aaaagaaaat tatttaagac tcaaaaacta
    44221 gctaataata taaaagaaaa gaaactattt gatacattag aaaagataac agaaatagtt
    44281 gaattagaaa aagaatctat aaaacaaaat aagcttttaa gagatgaaga ggatggtagt
    44341 tatagaaaaa gggtaataaa tatgttgtta aagactggta tgtttccctt tactaaaaat
    44401 aataaagtgg atgtatttgt agatggaaat gaaaagttta aaagacttat agaagatata
    44461 agagaagcta aagaccatat tcatttagag tactttatca tcaaagatag tgaaataggt
    44521 agggtgttaa aagaagaact tataaaaaag gctaaagaag gcattaagat aagaatttta
    44581 tatgatgatg taggatgctg gagattttgg tttaatagaa aattttttcg agaaatgagg
    44641 gaagtaggta tagaaattgc agcattttta cctacaaaat ttcctataat aggagggaaa
    44701 ttaaactata gaaatcacag aaaaattgtt gttattgatg gaataattgg atatacaggt
    44761 ggaataaata taggagatga atatttaggc aaaaatgata agtttggata ttggagagat
    44821 actcatatta gaattaaggg tatttctgta tacatgcttc aaatgacatt tctgattgat
    44881 tggtattata cgacaaaaga agtattagtg actaaaaatt atttcccaag tgtagggaat
    44941 gttggtgaaa gtatgataca agttgttgcg agtggtccag acagtgactg ggaagatatt
    45001 cattatgctt atttttctgc aatatgtcag gctagaaaaa atgtttatat agaaactcca
    45061 tattttattc cagatgaaag tctactaaaa gctataaaga gtgctgctct tagtggagtt
    45121 gatgtgagaa taatatttcc taaaattgca gaccacaaga tagtaaatat agcatcttat
    45181 tcatattttg aagaaatatt aagagcaggt ggtaaagttt atttatataa taaaggattt
    45241 atacattcta aagtcgtaat aatagatgat aaaattgctt ctgcaggtac agctaatatg
    45301 gatttaagaa gttttatgct taactttgag gtaaatgcat ttatctatga tgaagaagtt
    45361 attagggtaa tgacagatga tttctttgag gatttaagtc actgtgaaga acttaatttg
    45421 gaggtattta agaatagaaa tatcatacaa aaaatcaaag aatctgtagc aagattattt
    45481 tcaccaatat tataaaaaat tattaaaaaa ggtattgaaa attatgtgtg attggtatat
    45541 tataataatt gttagcactc tattagatag agtgataata aataaaaagt atatatataa
    45601 atctacatat ataagtagta ttaatttaaa aataactaaa aacataggcg aactagtcta
    45661 tacttaatat tttaggaggc gtgaataatg aaaataagac cattagctga cagagtagta
    45721 attaaaaaag tagaagcaga agaaaaaact gcaagtggaa tagttttacc aggagcagct
    45781 aaagagcaac ctcaaatagc tgaagttgta gaagttggac caggtggaat agttgaaggg
    45841 aaagaaataa aaatggaatt gacagtagga gataaggtta tattccaaaa atattctgga
    45901 acagaagtta agatagaagg acaagaatac acaatactaa gacagagtga tgtattagct
    45961 gttattgaat aaatatagaa taaatttatt aggaggggtt taaaatggct aaagaaatta
    46021 aattttcaga ggaaacaaga agagctttag aagctggtgt aaataaatta gcagatacag
    46081 taaaagtaac attaggacct aaaggaagaa atgttatatt agataaaaaa tttggttctc
    46141 cacttataac taatgatgga gtaactatag caaaagagat agaactagaa gatagatttg
    46201 aaaatatggg tgctcaatta gttaaagaag tagcaactaa aactaatgat gtagctggag
    46261 atggtactac aactgctaca gttttagcac aagctataat aagagaaggt ttaaagaatg
    46321 taacagcagg ggctaaccca atacttttaa gaaaaggaat acaaaaagca gtaacagtag
    46381 cagtagaaga attaaaaaat caatcaagaa tagtagaaac acaagaggct atatctcaag
    46441 ttgcttctat atctgctggt gatgaagaag ttggaaaatt aatagcagaa gctatggaaa
    46501 tagtaggtaa agatggagtt ataactgttg aagagtctca aactatgaat actgaattag
    46561 atgctgttga aggtatgcag tttgatagag gatttgtttc tgcatatatg gttacagatg
    46621 tagataaaat ggaagcagtt ttaaacgacc catatatatt aattactgat aaaaaaatat
    46681 ctaacataca agaattatta ccagttcttg aacaaatagt tcaacaaggt aaaaagttat
    46741 tgataatagc tgaagatgta gaaggtgaag cattatctac attagtagta aataaattaa
    46801 gaggaacatt tgatgtagta gcagttaaag ctccaggctt tggagataga agaaaagaaa
    46861 tgcttcaaga tatagcaata cttacaggtg ctcaagtaat atcagaagaa ttaggttatg
    46921 atttaaaaga agctgattta tctatgctag gtagagcttc atctgttaag gtaactaaag
    46981 aaagtactac aatagtagat ggttctggag ataaaaaagc tatagaagat agagtaactc
    47041 aaattaaaca tcaagtagag caaactactt cagattttga tagagagaaa ttaatggaaa
    47101 gattagctaa acttgctgga ggagtagctg ttgtaaaagt tggagctgct acagaagtag
    47161 agttaaaaga aagaaagtta agaatagaag atgctcttaa tgcaactaga gcagctgtag
    47221 aagaaggaat agtagctggt ggaggaactg cttttgttag tgttatacca gcaataggaa
    47281 cactaattga gagtttagaa ggagaagtta aactaggtgc tcaaatagtt aaaaaagcgt
    47341 tagaagagcc attaagacaa atagctataa atgctggtct tgaaggtgct gtaattgtgc
    47401 aaaatgttgt taattctgaa gcagaaactg gatttgacgc attgaatgaa aaatatgtaa
    47461 atatgataga agctggtata gttgacccaa ctaaagttag tagaagtgct ttacaaaatg
    47521 ctgcatcaat agcaagtact ttcttaacta ctgaatctgc tgttgctgac cttcctgaaa
    47581 aagaagatgc aggaatgcca ggaatgggtg gcggaatgcc tggtatgatg taatttaaaa
    47641 aatttaaaat ataaatttta atataaagaa ctatttcgac ttagatttta aactctaagt
    47701 tgaaatagtt cttttgtata tatctaattt ttgtatatct ataaattcaa tacacatatt
    47761 tagataatca gtatctagtt tgtaataata ttttagagta gtattgttat tttttaggtt
    47821 atgattttag atatatatta attaaggtat aattgttgat agagaataaa tcaaatttaa
    47881 aaggatgcga taatatggac ttaagaaaat tgcttgaaga agttaaaaat gaaaatattg
    47941 atatagattt tgcgttagaa aagttaaaag atttacctta tgaagacctt ggatatgcaa
    48001 atatagacca tcatagagaa ttaagaaatg ggtatccgga agttatttat tgtgaaggta
    48061 agagtgatga gcatatttta gggattattg ataaaatgaa tcaaaaaagt tctaacatat
    48121 tggggacaag gtgcagaaaa gaaacttttc tgaaaattaa agaaatctat aatcatgctg
    48181 agtacgaaga ggcgtctaaa attcttaaga ttcaaaatca tgatatagag aatataggaa
    48241 aaggtaaaat tgtgattgct acagggggaa cttctgatat accagtagca gacgaagctt
    48301 atcatacagc taagttttta ggtaatgatg ttgatagaat atatgatgtt ggagtggcag
    48361 gtatacatag gcttttaaat aaaagacata aaatagatag tgctagagta atagtagccg
    48421 ttgcaggtat ggaaggtgct cttgcaagtg taattggtgg actggttgat gttccagtaa
    48481 tagctgttcc aacttctgtt ggatatggag caaattttgg aggattagca gcattgctag
    48541 ctatgttaaa tagctgtgca tctggaatat ctgttgtaaa tattgataat ggatttggag
    48601 caggatattt agcatcaatg ataaataaac tgtaaataca ttgatataaa ttaaacaaaa
    48661 ctatataata aaatttaatt tctattatat ttttactatt aaaattgagg agacatatat
    48721 gagtgaaaaa atactttatt ttgatataat aagcggtata tcaggggata tgacccttgc
    48781 aagtttatta aatttaggtg tgcctaagga aatttttttg gaggaaattc ataaactaag
    48841 aatgagcgat gaatttaata taaacatcag ctcgaaaact gaaaatggaa tagtaggtac
    48901 aaaagtagaa gtaattacaa aagaaaaaca tacacataga aatttagtgg atatatttga
    48961 ggttatagat aaaagcactc taaacgaaaa tgtaaaatct aaagcaaaaa aaatatttat
    49021 ggtaattgga gaagcagaag caaaagttca tggaactaca atagacaaga tacattttca
    49081 tgaggtaggg gctatagatt caattgtaga tatagtagga gcttctatat tagttgactt
    49141 actttgtgta gataaagttt gtgctagtac agtgtctgtt ggttcaggat ttgtaaaatg
    49201 tgaacatgga attataccta tacctgcacc tgcaactata gaaattttaa aaggtgtgcc
    49261 aattaaatta aataatgtaa atggagaatg tacaactcca acaggagctg caatcataaa
    49321 agttttgtgt gatgagtttg tagatgagct tgaattttct ccaaagcaaa ttggatatgg
    49381 tataggtcat aagaagtttg aagtaccaaa tatactcaga actgtattag gtgaaaaaaa
    49441 aaagaagaat taatttatga aattagtgca aacattgatg atatgtcttc agaaatctat
    49501 tcttatttgt atgaaaaaat attagatgag aaagcattgg atatttatac agagagcatt
    49561 tatatgaaga agaatagacc agcaacaaaa gtatcaattt tatgtagtga atcagattta
    49621 gaaaaattta ttaaaatatt acttttagaa actagtactt ttggagtgag atataatgca
    49681 tataatagag aaattctaga gagaaaattt gtaaaattag atacaaaata tggagtggtt
    49741 acagtaaaac tagggtatta taaaggaaaa ctagtcaagg ctactccaga atataatgaa
    49801 tgtaaaacta tagcaaaaaa tgaagatatt cctataaaaa aagtgtttgc tgatataaat
    49861 tttagaataa aagaagaatt tagtgaaaac ttattgacat aagtaataaa ttttgataaa
    49921 ttaatattca gccttattaa ataaaagtaa acagaaaaaa atatataaaa tataaactca
    49981 ctcgtatatg ctcagaaata tggtctgaga gtctctacca agataccgta aatatcttga
    50041 ctatgagtga aattattata ccaaaagacc tagttaagta aatgtgtagg ctgagttaaa
    50101 ctccctatgt gttggctata agataaaggt attttggaag cctgtatagt aatttcactt
    50161 ttgctagaaa ttatggaagt tactatacag gttttttgtg taaaaagatt taatataatt
    50221 tagactgtat tgtgttaaaa taaatatata aaaactatat tatacaagga gagatgtgaa
    50281 tttatgaaac atgaattagt acttgtaata gattttggag gacaatataa tcagttgata
    50341 gctagaagag ttagagaaaa caacgtatat tgtgaaatac ttccatgtac tgcaagcata
    50401 gaaagaataa aagaaaaaaa tcctaaaggg ataatattta caggcggtcc aaatagtgcg
    50461 tatttagaag attctccaac aatatcaaaa gaaatatttg aattaggagt accaatactt
    50521 ggaatatgct atggtattca aataatgtct catgtattgg gtggagttgt aagaaaaggt
    50581 aataaacaag aaaaagaata tggaaaaaca gctataactt atggaaaatc atcattattt
    50641 gaaggaataa ctacaaatag tgtatggatg agtcatacag atttaataga aaaagttcca
    50701 gaaggattta ctatagttgc aaatactaat gattgtccag tagcagctat ggaaaatgta
    50761 gaacgaaacc tatatggagt tcaattccat ccagaggtgg aacactgttt ggaaggggat
    50821 aagatactta caaacttctt atataatatt tgtaaagtaa aaggtgactg gactacagat
    50881 tcattcatag aagataaaat aaaagaatta aaagaaaaaa taggcgataa aaaagcttta
    50941 tgtgctttaa gtggaggagt tgattcttct gttgctgcag ttcttattca taaagcaatt
    51001 ggggacaact taacttgtat atttgttgac catggtttac ttagaaaaaa tgaaggaaat
    51061 gatgtagaaa gaatatttag agagaaattt gatataaatt taataagagt taatgcagaa
    51121 gatagattct tatctaaatt aaaaggagtt tctgaaccag aagctaagag aaaaataata
    51181 ggtgaagaat ttataagagt atttgaagaa gaatcaaata aattaggaaa aatggatttc
    51241 ttagtacaag gaacaatcta tccagatgtt atagaaagtg gacatggaaa tgctgctact
    51301 ataaagtctc atcataatgt tggtggaatc ccagaagatg tagacttcca agaaattgta
    51361 gaaccattaa gagagttatt taaggatgaa gttagaaaaa taggattaga gcttggtata
    51421 gaagaaggat taatatttag acatcctttc ccaggaccag gtctaggaat aagagttata
    51481 ggtgatgtaa ctaaagaaaa atgtgatata ttaagagaag ctgatgctgt ttatatggac
    51541 gagcttagaa aagcaggttt atacagagaa atatggcaag cttttgcaac attaccagat
    51601 gttaagactg ttggagttat gggtgatgaa agaacatatg cttatttagt tggtttaaga
    51661 gcagttactt cttctgatgg aatgacttct gactggtata agatgcctta tgatgtatta
    51721 gaaagaattt ctaatagaat aataaatgaa gttgatggag taaatagagt agtttatgat
    51781 ataacttcta aacctcctgg aactattgaa tgggaatagt aaataaaaaa gtcgtaagcc
    51841 ttgtattttc aaggtttgcg acttttaaaa aaatctttgt gatactaaaa tgatactata
    51901 tatttaaatt atctagtttt tgggcaactt caagttgctt atttgggtat aaatgtgaat
    51961 atgtattcca agttgtttct actttttcat gccccaatct ttctgctata gttaatatat
    52021 ttacatccat atttaccaat aatgacgcat gagaatgtct caaatcatgc actctaattc
    52081 tttttacatt agataactta cagcatctat ctagctcttt agaaagataa cttttagcaa
    52141 atttaaatat tctttcatta tcttttaagt catatagctt agatagataa tcttttatat
    52201 tattatataa gaaatgtggg atagggacaa cacgtttact tttaggagtt ttaggagaag
    52261 aaacaatatc ctctccattt agtcttatgt agcttttttc gacgcttatt ttattttcga
    52321 aaatatcttt tggagtaaga gctaacaact cccctagtct aagacctgtc caaaataaaa
    52381 tttcaaatgc tagtctaggt tctgatttct tttcaaattc aataaatttt ttaaactctt
    52441 ctaatgtcca aaagttcatt tcatctgcgt tttttttacc gatagaacct gccaaatgag
    52501 caggattaga aggtaagtta taatatttaa ctgcataatt taatacagca acaagctggt
    52561 tgtttatcgt tttaatatat gtttggctat aatcactttt taataattcg ttttgccatc
    52621 ttcttatatg tgttgcagta atttcattta tttttagact tttaaaaaaa ggtaaaattc
    52681 taaagtttat taaatacttt ttagtttcta atgtagataa ttttaatcta gaagacatat
    52741 cgtgcatgta ttcttctatg agactttcaa aactcatatc agtactcatt ttagatttat
    52801 tcaaaaattc tctttcaaac tctagagctt cttttttagt tttaaaacct ctcttaattt
    52861 tctttttcct atccccatcg aagtctgtaa aataaaagct agcataccaa ctttttcttt
    52921 gttcgtcttt gtaagcaggc attttagaca cccccaatta tgtcatttta atattacaat
    52981 aattataaca tgttagatat gctatctaaa taattgtttt attttcctct tctttttatt
    53041 tcttgaagct tgtaatattt acacagttct aagaagtctt cttctagtgc tatagataag
    53101 tctaatatcg tagatatacc tatatctttg tactcttgat tttctagttt tgatatataa
    53161 cttctgttac gtctcatttt ttctgctaat tctagttgtg tcattctttt cttttttctt
    53221 aattttttca acatttatta aaatccacct tttaattatt tttatgacat ttttataatt
    53281 aatagtttgt gtaatttctt gtaaaaaatg ttcctcatta gaacattttt tggtggaaaa
    53341 atgtgttaaa atgtaagtaa gaaaagcact ttcaaagcac tataaaaata gtgctgaaat
    53401 agataaacaa ataaaagtaa taaggaggaa agatagattc tagagggaaa tcattatcat
    53461 ttttaagaac gtatgttcgg ttggtgggat agaaaaatac tttacagggg atggtttatt
    53521 tgaatgagaa tgaaaatatg agtttatatg tcagtaagtt aaaagaagta ttgaaaaata
    53581 attcagaaga gtataaaaaa ataagagcta aaataaatga aatttataat ctaaatgaaa
    53641 agaaagaata aaagggcttt agctctttta ttctttctta gtattaactg ctttataata
    53701 agcattatct atcatttttt ttattgcatt tttatcatct gaatctaaag atgctaatct
    53761 atttattagt tcgttaactt cattatcttc ttttgagtta acttttttta ataattcatc
    53821 atcttgttga gtgttaggtt gtattttacc taatttagtt aatagctcct ttaaagttaa
    53881 atttaatcca aaactcattt tttcaagcat atctaaagta ggttcaacag ctttaccatt
    53941 ccttgggtct ctgttttttt ctatcttatc tatatatgta tggctcacac cacaaagatt
    54001 agaaaattct ctaagagata agttatgttc acttctatat tctttaataa tttctgctaa
    54061 tgtttgcata atttcacacc tcatctaagt aatagttgac ttaattatat cagaaaaatg
    54121 taaactattg ttaacaaaaa taaaaattta gtaaaaaata attgacaaga gtaaaaaaaa
    54181 gacgtatact atgattaaca aaaaggttat aaataaagtt aggagggatt aatataaaaa
    54241 ataatttaca atatattaga aaagaatcta gaatatcaca aaaaaaattc gctgataaga
    54301 taggtatatc aagaccgtat ttatctagaa tagaaaacgg taaggttaat ccgagtttag
    54361 aaatagcgca taaaatctcg ctcgaaacag ggaaaacaat aaatgaaatt ttttttgatt
    54421 ttactgtaaa tcatagtaaa ctataaggtt ttaattgtac cttgaaaact aaatataaaa
    54481 tattttaaag gagcaagtat atgaaaaata aagaaaaaga aataatcatt agaggaattt
    54541 taataggaat tttttatttt ttaggaattg tatttagtaa tacttttttt aaataataaa
    54601 tagaaggggt aggtgaaata ccaactcccc aaatcaaaat aacactttgg aagttaaata
    54661 tagaatattc aaaagaggtg attagatgga aatagagcaa acaacaatac gcctgctaaa
    54721 aagcagacga aagttgaata ttaatttcta ttttggttag gcgaaagacc taacaaaaaa
    54781 tctgtagata cattaagttt gttagaaatt aatattaaag tttctatatt tggctctctt
    54841 gaacccgatt cataatattg atatgcacgt tctgagatac caaacaaact agcaaattgc
    54901 ttttgagtca tattcatttg ctttcttact agcttaatat tatctttgaa tttagtcata
    54961 actacacgct ccaataaaaa aataaataaa tttcttgaca cgaacaatat tagcgtgtaa
    55021 tatataaaac atagcacgaa caatattggc gtgttaaata aaaaggagag ggtgaaaata
    55081 aataacaatt taaaactaca acgtgaaaaa gttggcttaa cgcaattaga ggttgctcaa
    55141 aaagccaaaa taacagagag aagctatcaa tattatgaag ctggcgaacg tctcccaaac
    55201 attcgtacag ctttaaagat agctagaatt ttaaatacta attgtgaaaa actctttaat
    55261 gaataatagc ataaaaggac tcagattaca agaagggagc tttagatatg aataatttgc
    55321 aacttaacaa taaaaataca ataacaacat tagaaattgc tgatatgtta gaaattaacc
    55381 attgggaagt attgagaaaa ttagaaggca cagaaaaaac aaaaggaatt attgatattc
    55441 ttaacgacaa caattttgtt gtggttgatt actttataaa atcagcttat ttagatttaa
    55501 aaaatgaaaa tagaaaatgt tacaatgtaa cgaaattagg ctgtgacttt ttagcaaata
    55561 aatttactgg agaaaaagga attattttta cagctagata tgtaaaaaga tttaataaaa
    55621 tggagcaaga gttaaaagaa caacaaccta aattaccaac tacatataaa gaagcattgc
    55681 aacagttatt aatagaagtt gaagaaaaag agcaattaca attagagaac caggcaatga
    55741 aaccaaaagc agattacttt gatgctttag tagaaagaaa cttgttaact aatataagag
    55801 atacagcaaa agaacttgga gttaaagaaa aagtatttgt atcatggtta atagaaaaga
    55861 aatattgtta tagagattca aaagataagt tacaaccata tgcaaataga atgcaatact
    55921 tcgagaaaaa ggaatttaca aatgagtatg gttattcagg tgtacaaact ttgattaacc
    55981 caagaggtag ggaagctatc agattattgc ttataaagga tggattaatt aaagaaaaag
    56041 aaaagggatg ccaaataact ttattaggtt agaactttga aaactaaata cagaatattt
    56101 tgaaagtagg tgtattgtat ggcaaaagca gtagctaaag aacaattgtt ttatagggca
    56161 aaagatatag ctaaattttt agatatatgc gaagcaactg catacaaaat aattgcagaa
    56221 ttaaatgaag aattagaaaa agaaggtttt aagacttttt ctggcagggt atcagttgct
    56281 tattttaaag aaagatattg ttataagcca agaaaggggg tgatttagtt gaatgtaaag
    56341 gtactaatag cttatataca gttttgcaat gataagcaaa taaaagcaag ttttgaaggt
    56401 cttagaaaat acaacagaga tatagagtta gttaacttat atttaccaac acatttaaaa
    56461 ataaagtagg aggtttaatt gtatatggta tttaatttag aggagttcaa agtaggaaat
    56521 gcagtaagaa taagttgtga aagatttggt tttgaaattg attgtattgt agtagtagca
    56581 actgagaagg aactaaattt agcttacttt gataaagaaa gaggttgtat ggagtatcaa
    56641 gcattgatac cagaagacct tagatatgac gattatattc ttgaaagatt aggttagggg
    56701 gtgtatttta atggaaacag ctatatctat tgcaaaaggt caaatagaag gagcgaatga
    56761 gagtataaag gaattaaaat caaaagaaaa ttacgataaa gaaagtttaa gatggtggga
    56821 aggtgttaag caagctagtg aaaatatact agagttttta gaaatagaaa ataaggcata
    56881 agaaaagagc cattacgatt ggctcaattc aaaaacataa taaaatttaa ttagctatat
    56941 tatagcacaa gggggaacta aaatgaaagc aattttatta aaaggtttag aaatagaaaa
    57001 tttcaaagga ataaaagaac ttcgcataga ttttaacaac ataactaata tatttggaga
    57061 aaatgcaaca ggaaaaacaa gcatatttga tgcttttacg tgggtaatgt ttgacaagga
    57121 tagtaagaat agaagtgtat tcgagataaa gcctttagat aagcaaaata aagtcattag
    57181 agggcttgta acaactgtta cagcagtact ggaagttaat aataaagaga ttaaattaac
    57241 taagaaatac gaagaaaaat ggactagaaa aagaggggaa tcagaagcaa cttttactaa
    57301 gaatgaaaca acatatatga taaatgatac tcctattaaa aaatctgaat atgtaaaaga
    57361 gatagctgaa atagctgacg aggaacagtt taaattactt actaatccat actttttttc
    57421 aaatgagctg aactggaaaa aggctagaga agtaatttta gagatatgtg gagatataac
    57481 aatagaacag attatagagt caaataaaga cttagtttta cttactacag agtttgaaaa
    57541 ggaaaataac atagataaga ttattaaaaa tagaaaagct agtaaaaata acttatctaa
    57601 ggaaaaagaa gaaataccag ttcgtataaa cgaatgtaac aaaggtatgt acaatataga
    57661 ttttgaggaa atagaggttc aattaaaagc taagaagtct gatttagaag ctattgagga
    57721 taatctttta aatggtacaa agacaaatga acagatttta aaagataaag aaaagatatt
    57781 tgaactaaag caagagacac aaagtattaa acaatcagcg agtaaaaaag gaaataagaa
    57841 aaggaatgag ctgttaaaag aaaaggatga gttgcaatat aatattaaaa atttaagaaa
    57901 taatcttgtt tatttagaaa gggatagtga gttaaaagaa actttgagaa aaagagcgat
    57961 tgaaaaaaca acaaatttaa gagataaatg gactaaaaag agtcaggaaa cattagattt
    58021 aagcgttatt cagactgagt gtccaacttg caaaagacct cttgacttag aagatataga
    58081 agaaaagaaa aaggaaatgt tagataattt taatctaaat aaagctaaag aactaaaaga
    58141 aatagtagaa ctagggaaat ctaaaaatga tgatgtagaa ttatttaata cagaaattga
    58201 aagattaaaa gtagatataa ataagacttt agaagagata caagaaaaag cagtattatt
    58261 agataaaata aaaaaagaat tagaaagtac aaaatctaca gagatatatt cagcagatga
    58321 ggaaaaaaga ttaacagaaa ttagtgtaga aataaaagag ctagaagaaa aaataaacaa
    58381 taaagataat gataaaaaca ttgatgaact aaaagaaagt aagaaaaaac tagctgttga
    58441 aattgagtta cttaataaag aactagctaa aagagatatt aacaaaggac tattagatag
    58501 aaaagagcag ttattagaaa aagaaaaaga gctaggtata gaactagctc atcaagaaaa
    58561 aatactcaac ttatgcgaat tatttataaa aactaaagtt agtttattag aaagtaatat
    58621 aagtagtaag tttaagaatg taacatttaa attattcaaa gagcaaataa atggaggtat
    58681 tgaagaaact tgtgaggcat tagtggatgg agtaccattt tcaaatgtta atacagcagg
    58741 acaaataaat ggaggactag atataataaa tactttatct aatcattttg gagttaaaat
    58801 gccaatattt attgataaca gggagagtgt gaatgatttg attgatattg atagtcaagt
    58861 gataaatttg attgtaagta atgataatcc attaaaaata aaaggagtga attaatatgg
    58921 caaatgaaat acaaagacaa gtaagcgtta aaaatctatt atctacagaa gcgtataaga
    58981 aaagatttaa agaggtatta aaagataagg ctaatacatt tatggcatca gtggtgaatg
    59041 tatctaactt gccaagccta aaggatgccg aacctaattc gattttaaaa tctgccatgg
    59101 ttgcagcaac attagattta ccaatagacc caaatttagg cttctcttat ctagtacctt
    59161 ttgtaaacaa aggagttaaa gaagcgcaat ttcaaatagg atacaaaggg tttatacaac
    59221 tagctatgag gactggacag tataaaacaa ttaatgcaat agaaatctat gagaatgaga
    59281 ttaaaagtgt taacagacta actggagaaa tagaatttaa tgaaaataaa gacgagatag
    59341 acaatgagat agtcgttgga tatatagcat attttaaact gctaaatggg tttgaaaaaa
    59401 ctttatatat gagtaaagaa gatatggaaa agtatgctaa aagatatagc cagacataca
    59461 aaagcaataa ggattatgtt gtaaaatcaa gtctttggac aactgatttt gatgctatgg
    59521 cagttaaaac ggtacttaaa aggttgttat ctaaatacgg gatattaagt atagaaatgc
    59581 agaaagcttt agagactgac caagcagtta taaaggatga taattcagtt gaatatgtag
    59641 acagacaagt agaagaagaa atagaagaaa atgctaataa aaagactata gatatgacaa
    59701 cagaagaaaa ggaaaaagct attgaaatta aagaatctaa gcccgaagaa gcaacccaag
    59761 ttgaattgga tacaccacca ttttaaggat gaaaatcaaa gtattaggga gcagtagcag
    59821 aggtaattgc tacttgctcc aactgaaaaa tgagacatta attttagagt gtggagtcag
    59881 ttacaaagag atattaaaag gcttagattt cagtttagaa aatgttgtag gatgtttggt
    59941 cacacatgaa cataaagacc actctaaagc tatcacagag cttacaaata atggaataga
    60001 tgtatattct agcaagggta cattagaagc tttaaaaata gaaaatcata gaactaagat
    60061 tatagaaagc gagaaattat tcaagatagg taactttaag atagtgccat ttaatactaa
    60121 gcatgatgcg gtagagccat taggattttt aataaatcat agtagttttg gtaacctatt
    60181 atttataact gatagttatt attgtgaata caactttaat aatttaaatc acatcatgat
    60241 tgagtgtaac tatagtaaag atttattaga taacaacaaa gataagattt atttgagaaa
    60301 tagaatagtc aaaagtcatt ttgaattaag taatgtgatt aattttctaa aagtaaatga
    60361 tttaagtaat ataaaaacaa ttacattgct tcatctaagt gaagataaca gtgataaaga
    60421 tttatttata agagagatag aaaagaatgt gggagtacca gtaatagtag ctgaaaaagg
    60481 attagaaatt tatttagact agaggtgata aagtggcaaa atatagaatt ttacaagcta
    60541 acttttggga tgatggattt gtattagatt taactcctga agaaaagtac ttttataact
    60601 atcttttaac taatggtaga gcaagtcaat gtgggtgtta tgaattaccc tataaaatta
    60661 tggaaatgca aacaggatat aacagggaaa ctgtagagaa gttaattaaa aggtttatag
    60721 agtatggaaa aataaaatat gactctacta ctaaagagat attaataatt aattggagta
    60781 aacataattt ttctaaaagt ccaaaagtac gtacttgtat cttaaaagag gttgaatcaa
    60841 ttaaaaataa agaatttcag cagtatatgt atagagtatg tatagactat ggatacccta
    60901 tcgatacagt atctatagac tatggggaaa aagaaaaaga aaaacaaaaa gaaaaagaaa
    60961 aacaaaaaga aaaagaaaaa caaaaagaaa aagtagaacc gttaatttgt gaagaacagg
    61021 aaaaaaatga gttaaaagaa tttaagaagc tatatgaaga aaatatagga gtggtatatc
    61081 cagttacagc agaatggtta atagaaattt ctagtgatgt agatataaga ttatttaaat
    61141 ctgctataga gatatgtgct gaaaagatga atatgaatat agcatactta aaaggtatcc
    61201 ttaaaaagtg gaaggatgcg aatataacta catatgaaca actagaatca tatagattac
    61261 agcaagaaaa taagaaagca aaaaaagtag ttaatggcca actaagtaaa aataagtttg
    61321 ccaactttga acaaacattt actaagtata cagagaatga gcttgataac ataattaaga
    61381 aaagtcaaga tgctaagttc aaataaaatt aaacttctag gaagtaaata tcaatatatt
    61441 gcttcctaga aagggggtag aatatgggta aaatttggat ggatgcagga acatttttgg
    61501 aaactaaaga tataggagat attgaatgta atctaagaga aatgataaat aaaaataaac
    61561 aaaaaaattt aattggtaga ataaattcca aaggacaagg aagaaaaagt aagaaagtag
    61621 agtgtactaa catcattact ggagagagta aaatatttgt cagtgctgta gaagcaagtg
    61681 aatatttata tttcacggaa cttcatatta ctcgtctagc aagaacagga aagactacta
    61741 aaaatggttg gaaagttaga tatattgaag aggtgtcaaa tggtattagc aaatgtggaa
    61801 caagtaatta agttagctga aaagatatta agtaagaaaa agtgttctgt taataaagct
    61861 attgatatag ctataaaaat attaaataga tacgaatatg aggggatgat taaatgagtc
    61921 taattgaata tagaggttat gattttgaaa ataaaaagtg gatttattct aaaacaataa
    61981 tgtggagtaa tgcagtagac tgtttattaa tgctgaaaga agattttaaa tggcgaaaag
    62041 tttgtaatgt tggaatatgt tctgaagaat gggctggaaa taatcaagaa atttttgaag
    62101 gggatatatt aaaagaaaat tataatcctc acaatagaag ttcatatgga attgtaaaaa
    62161 gagattttaa tagtattaag ttatatttgg agtggcatta tttaaagaag tttgaaggag
    62221 aatggataga gattatagat aaaacagaaa tatatcatag tagaggttac aaagtaattg
    62281 gtaatgaata tgagaactta gaggaagtta ggaaagagtt tttagaacgc aaggagatgt
    62341 tggaaaatga acgtcttagc tagtttaata cttatagtag gaagttttat agctggtagg
    62401 gtttatgagt atagattgaa tctaaaagag tttgaaaatt atgataatat aggaggtttt
    62461 aagaatgaat gatagattag aaatgataaa tgcttctgta aattatatac agatgatatg
    62521 tgaaagttca aatatagcta ttatagcaga gcatgaccga gttagaatat tggatttaga
    62581 aactaaagaa aagtatgacc tattaagaag tgagggggat taaaaaatga gtaaagttat
    62641 acaatgtgat ttctgtaagg aaatatttga aaaatataat ggagaatgta ttgagctata
    62701 taaaaaggat tgtagcaaag gggtgcttgg gatagataaa cacatatgcc caacttgtta
    62761 tgaaaaattc attgaaggaa aaatagagaa agtagaaaat gctaaaagat ttaaggataa
    62821 attaatagac ttcttggttg agcatgaggt ttgtgactgt tgtgcttgcg actgtgtgtt
    62881 tgattctaat gacgaaaaaa aatgcaaggc aggaattaga gagtgggttg aaagtgaggt
    62941 agaagaataa tatggcaaaa ttaatagtta gcataccttt aactaaatat ttaaaagata
    63001 taactaaaga atggggagaa acttatataa ctaaaacata tggtgggcat gtctatttaa
    63061 gtgatgaagc tccaggagaa gtacttaaaa aagaagatga tttaaattat atagagttta
    63121 acgattctga tattgtcatg agattaccta aagaagtaca tcaacatata aatttgaaaa
    63181 aaggttgcaa caagaatctt aaagatgtat taaaagaaat aaaaaagata gaagagaaaa
    63241 caaatatata gaaaatatct aattaaaaca gtttagagag ttgcaaaata tcttttagta
    63301 taaatttatt gttgaagtgt tttgtgactc tcaaaaatga aaataaggag gagctatatt
    63361 gcttacattt ttagatttat tcgcagggat aggtggtttt aggctaggaa tggaaaaagc
    63421 aggacataaa tgtttgggac attgcgaata tgataaattc gcaaatttaa gttataatgc
    63481 catgcacaaa ccgaaggagg atgaatggtt tgaaagagat attagagaaa ttagaacaga
    63541 aaatatccca agagcagatg tctggtgttt tggattccca tgtcaagaca tttctgttgc
    63601 aggtaaacaa tttggattta aaggaagacg ttcaagttta tttttcgcag ttacaaaact
    63661 tattagagaa ctcaaagaag aagatagacc caagtattta cttattgaaa acgttaaaaa
    63721 tctacttagt gttaatggag gatttgattt cctcaaagtt ctcattgaac tggatgaaat
    63781 cggctatgat gcagagtggc aagttcttaa ctctaaaaac ttcggagtac cccaaaatag
    63841 agaacgaata ttcgttgttg gacattttag aggacgaagt acacgaaaag tatttcctat
    63901 cgaaagaaaa agtagaaaaa atcttgaaca actaaataat ccaactcata gtacaagtgg
    63961 agttttagtc aatgcagttt taacacccga tagggtaaac aaaagacaaa atggtcgtag
    64021 aattaaagaa agcggagaac caatgttcac actaacagct caagataaac atggaatttt
    64081 gaaaaatgga gatataagaa ggttaacacc aaaggaatgc tttaggttgc aaggatttcc
    64141 ggataaatat tacgaaagag cagcaagtgt atgctcagat agtcaactgt acaaacaagc
    64201 gggaaatgct gttactgcaa atgttgtata tgaaatagca aaaagaatgg gctaagagtt
    64261 gcaaaatgtc ttttagtatg agtattgttg aagtgttttg taactctcaa aaatgaaaat
    64321 aaggggtgaa taaatgtcaa agtatgtgct tagatggcaa aaagggttat tgttggatga
    64381 acgtaagata aattattcat gtggaagtaa agaaatgcta aaacaaaaag cagaattatt
    64441 agctaaagat gacaagatat tgcttgtaac aatagataaa gttgaagaag ttataaaaga
    64501 tactagaagt caaaaaatgg ctgaatatta ttgtgatgga ggaattgaaa tatgataata
    64561 cacaaattta taatacatgt tttagataag aatagcgata caccaatact aaatgatttt
    64621 gagggtaggg ttagtcaaga tattgaagct ttctttcaaa agaaaataag caaagtatca
    64681 agagataatg acatcagaac agtagtattt aatgactata gtaacaatct aattaagaag
    64741 tgttgtgaac aaattattta tgatgaaagt tcatttttaa ataactctaa agagattgca
    64801 gcttatttat ttgatgttat gaaattgaat gctatattag aatcttgcga cttagcaatt
    64861 tgcttatact ctcaaaaaga tgaaaagaaa gttgctatat taaagcttga ttacaataat
    64921 tcgtatactc attctattag ctttgaagag gataaattta atatacagat gtctaagaat
    64981 gaaattaata tacaagagac taagacggtt aaaattgctg ctttggttgg attgagtgga
    65041 atgaatgacg aatatcatct aaaagtattg gataaggatg cagagaagga agaagctaat
    65101 tctaagtttg ttacagagtt tctaaatgct actaaagtga aagatgacaa gtataggact
    65161 aaaaagttta aagatacagt tgaaaattgg ataactaatg ttcttggaaa tgatataaaa
    65221 caagctgagg acataagaag tatattaaat tatactttga aagaaaagca tgaaattgat
    65281 ataaaagatt ttgttgataa atcaattaaa gatgatgagt taaaaaatag ttttaaagaa
    65341 catatggaag aaaagggtct tgatgaaagt tttagcatag ataaaaaatg ggttgaaaaa
    65401 aagcttaaaa agagaaatat aaaaactgac aatggttttg aaataaaagg taacttaact
    65461 gattttgagg acccaatgaa atatacagta agacaaaatc aaaatgggtc tatagatata
    65521 attattaaga atgttaattt ctataatgaa aaataagggg gctacaatgg aaaataaaga
    65581 taattttgta ttaaataagc ttggaccagc aagtaaagta atgaaaaaag ttgaaataga
    65641 tgaaaaagaa attaagagtt atctaaaaga actaaaagaa tgtgaagaag taaaagtttt
    65701 tattattaga aaagatggaa ttgaaattcc aatagttttc aaagatggaa atatgaacga
    65761 atggttaaga aaagaaattg agataagttt tgatagattt aaggatgaaa ttgctcaagt
    65821 taaaaaagca ttgattaaag ttacaggaga gaattaagaa gttagaaggt gctcatatga
    65881 ctaataaaga aatgtgcaag tcaaataatc ttgatgaaag agaagtgtgt aaggaatttg
    65941 gaaaagagat ttgtggtagt tgtataaatg atagggtaga ttgcgaaagc aaagattgtg
    66001 atatagcata tgaaaattgg ctagagaaga atacagaaag ataattataa aaataaagtc
    66061 aaggtaagtt tgtgaatgaa actagaatgt tatagactta ctttgactta taaaaaagga
    66121 gtgtattaaa tggctaatat atattgcgaa aattataatt gtaaaaacta ctttgaagat
    66181 atgtgtatgc ttgaaagaat tgaaattaat aacctgaaag tgtgtgaaag ttacattgaa
    66241 ggtaaaaatg agctatataa attagaaaac ggatatacta tacatcctaa agatttgaaa
    66301 atggtgaaaa gtaaagatta ttctgttgaa gttactcata ttccaactgg tattacagta
    66361 aaatgccgtt ctacaaatag tattttaaaa aataaaaata agtgtttgga agttctagaa
    66421 gaagaattaa taaaaataaa ctctcactta gagctagaag atttaaacta aataggaagt
    66481 gagcttatga aacgaagaag atgcagttgg tgtggtaagc tattttatct taaggaaaaa
    66541 tctaaggatg tttattgttg taaagaatgt aggaagaagg ctaagaaggt gaaaaaatga
    66601 aagtttttct tgtaatagat ggagagccag ttggcaagga aagaccaaga atgaatactt
    66661 acgctaaaag gacctataca cctaataaga ctaagaatta tgaggaccta ataaaatggc
    66721 tatatcaatc taaagttaaa tattactttg aaggttatat aaaaatgact ttaagatgtt
    66781 attattctat agctaaaagt aacagtaaaa aggttaagga gcagaaaaga aataatgtgt
    66841 taagacctag taaaaagcct gacattgata atgtcattaa agtagtagct gattcactca
    66901 atgagatagc ttataaggat gatacacaga ttgttgaggt tgtagctagt aaatattaca
    66961 gtgataaacc aagagttgag gttatattag aagatgttat ttaaccaacg gaaaaatccg
    67021 ttcgttagat taggtactca gtttttcata aaaatgtgaa aaagctgaat agagaatata
    67081 tcaaatggta aaggagagat aaattatgaa tgaaaatata aataaagaaa taacagtact
    67141 tggaacttta gaaatcgagg gaatgaaatt tcataacatt gagggtggat ttggagaaca
    67201 taagaaagca atgctagtaa aagatatagc tgagatacat aatagagaac ttaaacatat
    67261 aaatgagcta attaataata atataaagag atttaaaaca aatatagata ttatagattt
    67321 aaaagtgagt cgttctgagc gactaggtga tttaaaggct aatccttttg aaggattagg
    67381 ttacgaggat gttggatata gtaaacaatc ttttaatcag tcaagaaata tttacttgtt
    67441 atctgaaaga ggttattcaa aactactaaa gatattagaa gatgataagg cttgggaaca
    67501 atacgagaaa atagttgatg gatatttctc tatgagaaaa gagttaaata accctctttt
    67561 aagtgcatcg aaggagttac aggctatatt tatgctagat aagaaacaag aagtcttaga
    67621 aactaaaata gagaatgtta atgagaagtt agagaacttt atggatgatg caccattatt
    67681 caatatcgag tgtgagtgta ttgttaaaga ggttaagaga gtagcaacaa aatcacttgg
    67741 tggacatgga agtaaggctt ataaaaataa atctttaaga ggtaaagttt atagtgatat
    67801 ataccatcag attaaacgag aatttggagt agatagttat aaggctataa agcgttgtca
    67861 gttagataaa gtattagaga ttgtaaataa ttataagtta cctatagtgt ttgaagaaga
    67921 aataagactt ttgaatagtc aattatcaat tgtgagttaa gacaggaata gatttttctc
    67981 ctttaaaggg gaaaacctgc aatagttaat taaaagagaa aaggagtgct ttcacactcc
    68041 acttgtcaaa aatataaaac ttttatatac aagattatta taacataaat aattgatagg
    68101 agtgtgtgag tatgtctaaa actaaaaaag agttttttaa tgcaactaag aaacaacttt
    68161 ctaattataa acaattaagt gcaaatataa taaaattaaa aaatgaaata caaatgttga
    68221 aagataattc ggttggagat ttaatgaaag gtataagtta tgatagtgtc aaaacaggaa
    68281 aaacaaacaa aactagtaac atgattgagg atgctattgt taatgtatca gacttaataa
    68341 cagaaaagga aatagagtta tatgaagcag aaataattaa atccacaata gatttagcta
    68401 taagaaactt aaaacctata cacagacaaa ttattgaact taaatatata gatggtctaa
    68461 tgtggcaaga aatggttgat atagtacatt tagaagaaag acaattaagt gtaagagcta
    68521 gtcaagctat tagctcaata tcaatagcat tatttgggaa gaaagcatta atagagcaag
    68581 aaccactttt tgaattgtta gattacaaac taaattaaaa aagtaagagt aattttgagt
    68641 gctgaaaatg tgcaggtttt tttgttttag acatgagata atagtattgt ggaaatgaat
    68701 atttctctct caaaactaaa tatatatgtg ggctaggtaa agggattcac ctagcttata
    68761 tgaacagact aggcagggcg tgaggacgct gttagttcaa ttctaactat gttcaatctt
    68821 tagtttttct atttcaatta atctacggat acactaaaaa atagtatttg aattgagatt
    68881 aaaatctcat acagttttgt atcttaattc agagtctaaa ccgagtgggg cttggtaacc
    68941 tcactcacca tgcaggtact ggtgtttaat ctaagttcga ttcttagaac ttgcgacata
    69001 atatatgtat ctccctattt aaaaaggcta agtgagggta agcttagtct tttaatttaa
    69061 aaaaaaaaga aatttttatt gtcataatac tatttgctta ggtatattat aatgtgcata
    69121 cttaaaatta aatacttagc aagcatttga attaatatac ataaaatata tgacataatt
    69181 ttttatagtg taagttattt aaattaatat aaataacagt aattttatta tagaaaatgt
    69241 atatattgtg aataataata ataataaaat cttgtacaaa atgccaactg ataattcctc
    69301 gaaatgtatt gtgtatttaa cgttacgatt gtataattaa cttataatag tgatatggaa
    69361 ggtggtactt atggctacaa aaagtatttt aaaaaatgta gatgtaagaa aaaaggcatt
    69421 tggaagaaat ctagtatcag ctctagaaaa tgctaaaaat aaacaagaaa aagaagttgt
    69481 attaagtaaa aaatgttcag aagtaccaaa agataaaata aaggatatat tcgggagatt
    69541 ttaatgagtg gctatttaat tgtaaactta agtaatatgc tgggagaact ggaggaagaa
    69601 gaagttaaaa aaattctctc cagtttttct tgtcctctta ataaagatgt agaagacttt
    69661 ttaaaaaaca aagctattga attttctaaa cagggtttag ctagtacaca tttagtatta
    69721 acttcttata aaggcaagcc tgttatagtt ggatatttca ctctagctaa taagtatttt
    69781 acaataaaaa gaaaaacatt aacaaactct ttagctagaa aagtagtaaa gtttggacaa
    69841 tataatgaag aactaagaag atatattatt ggagcacctt tgataggaca aataggaaaa
    69901 aattattcaa ataattataa taaattaatt aaaggtgatg aacttctaaa aattgcatgt
    69961 gacaagataa aagcagtgca gttagatatg ggtgggaaaa tagtatatct tgaatgtgaa
    70021 gacaaaccta agttaattga attttataag gataatggat ttgtagattt tggtaaaaga
    70081 agtcttgata aagatgaaac agattcattg gatggggact atctagtcca aatgttaaaa
    70141 tatctaaaaa aataaaagta cataaaatct aaaatgacta tcttgatgga tggtcttttt
    70201 ttatacaata aattaaaagg agaattatag aatgaaaaag ataactaaac ttatattatg
    70261 ttctttgcta gtaatcagta tagcgagtcc attacaagtt gaagctaaaa ctactcatca
    70321 ttccagttcg catgtttcta ttcataagag tagtacaaaa tctaaaagta gtagacctaa
    70381 aattactaaa actaaaaaag ctactaaaac atatagaact aacaaatcta tcaaaaagaa
    70441 aataaaactt aaaaaacaag taaacaaaaa aactcaagtt ccaaataaac aagctgctag
    70501 aaaagacaaa aaaacaacta catataatta ttacaatagc tataactcaa atagatacta
    70561 tactacttca agtagcgggt taagtttctg ggattgctat atgttaggtc atttattcaa
    70621 taacaacaat aaagtttcag agcaagatat agctagagag ttgcaaaaac aaggttatag
    70681 taaacaggaa actgataata tattaagaaa agcaaatcaa aatcaagcta aaaaagaaga
    70741 aaagaaaaaa agagtgatga tgttaatatt ctctgtatta ggagcattgt tcattatagg
    70801 tttagggcta ataatattta tcaaaaggga atcaaaaggt tgcaataaat caatgtaatt
    70861 taattagata catagactct aacaagagtt cttttttatt cccaaaacga caaacaaacg
    70921 aggtggtggt atgaatgaaa aggcagattt agcccatgaa gattacttaa aagggcttaa
    70981 gtacaaggaa atagctgaaa agcataatgt aagtttatcg actgtaaaat catgggcaac
    71041 tagatactgg aaacaaaaag gttgcaacca atcaaaaaaa gttgcaacca aaaagagagg
    71101 tgcacccata ggtaataaaa atgctactgg tccaccaggt aataaaaatg ctgaaaagtt
    71161 tggtttcttc tcaaagtatc tacctgaaga aactagggaa ttgatgcaag aaatatctat
    71221 aaaagataaa ttcgatattc tttgggaaca gataacaatt caatatgcag caataataag
    71281 agcacaaaag ataatgtatg ttaaagacaa ggaagaaatg attaaagaat taaagaaaca
    71341 tgaaagtaca gaaaatggag agaagataga gtatgaattt caatttgcat gggataggca
    71401 agcatctttt cttaatgcac agagtagagc tatgagtgaa ttaagaagtt taattaaaca
    71461 gtatgatgaa atgattcata aggattggaa tttggctaca gaggagcaga aaacaagagt
    71521 tgagaagttg aaatgtgaag ttgataacct aagtaaagat gacattggag atgatgagtt
    71581 gaaaataagt gtagattatg gtgatagaaa tgatagttag agtaaatttt aatccagatt
    71641 tcaaggaagc caattttact aaaaaaagat acagagcaat gaaaggttca gcagggagtg
    71701 gaaaatctgt taatgtagca caagactata tactaaagtt aggagataag aagtatcaag
    71761 gagctaatct attagtagtt agaaagtcag aagctacaca taagtattca acgtatgcag
    71821 agcttacagg agctataaat cgtatttatg gtaaacaagc tgataagtat tggaaaacta
    71881 ctttaaatcc tttagaaatt aagagtaaag ttactggtaa ctctataatt ttcagaggag
    71941 ttaatgatgc aaaacaaaga gaaaaattaa aatcaattaa cttctcgaaa ggaaaattaa
    72001 catgggtttg gtgtgaagaa gctacagaac ttatggaaag tgacatagat atactagacg
    72061 accgtttaag aggtatttta actaatccta acctatacta tcaaatgaca tttacattta
    72121 atccagtctc atctactcat tggataaaaa gaaagtattt tgactataaa aatgatgata
    72181 tatttactca tcatagtact tatctacaaa atagattcat agatgaggct tactacagaa
    72241 gaatgcaaat gagaaaagag caagaccccg aagggtacaa agtctatggt cttggagaat
    72301 ggggagaaac tggtggagca atacttaaaa actatgttat acatgaattt cctacggaat
    72361 ttgaatactt tgataatatg agactgtcac aagactttgg ctttaatcat gcaaatgtag
    72421 tactcagaat tggttttaag gatggagagt tatatatatg taatgaaata tatgtacatg
    72481 aaatggatac atctgaaata ataaagattg caaacagtaa aggtttagaa aagaatatat
    72541 ttatgtactg tgatagtgct gaaccagata gaattaagat gtggaagagt gcaggatata
    72601 aagctaaagg agttaaaaaa ggaccaggaa gtgttaaagc tcaaatagat tatttgaaac
    72661 aattaagaat acatgtacat cctagttgca ctaataccat aaaagaaata caacaatgga
    72721 aatggaaaca agatgaaaga actggattat atcttgatga accagttgag tttatggatg
    72781 atgcaatggc tgctcttaga tattctatag ataataagct taaaaataat ggaataagct
    72841 tcttaaagta aaggaggcgt taaatattta tataagtgaa acagatttaa taaaagttca
    72901 gttaaaaaaa gagagcacat ttaacctagt aaaagttata gagcattata ttttaaaaca
    72961 tagaccagag aaatataaac aaggtgaaga atactattat ggcaatgcag atataaacaa
    73021 taagagaaga tattatctct tagatggagc taaggttgat gattttacta aagttaataa
    73081 taaagcaatt aacaactacc ataagctttt agttgaccaa aaggtaggct atagtgtcgg
    73141 aaatcccata gtatttaatg cagatgatga taatctcact aagcttttaa atgacttact
    73201 aggagaagag tttgacgata caataacaga actatatctc aatgctagta ataaaggggt
    73261 tgaatggtta catccatata ttaatagaaa aggtgagttt aaatatgtaa taattccagc
    73321 tgaagaagca attcctattt gggatagtaa aagacagagg gaattagttg catttattag
    73381 gttttattat attgaagata tagatggaaa taaaataaaa agagttgagt actacacaga
    73441 aaatgacgta acttacttta ttgaaagagg taatagtttt attcaagaat ttttatatga
    73501 tgaatatgga aaaatgactg atatacaaga aggtcatttt agaataaata acaaagaaca
    73561 gggatggggt aaagttccat ttataccttt taaaaataat gaaaagtgtg tctcagattt
    73621 aactttctat aaatcattaa tagatatata tgacaataat atttctacac tagcagataa
    73681 cttagatgaa atacaagagg ttatttatgt attaaaagaa tatccaggaa caagtctaca
    73741 agagtttata gataatataa gatactataa atcaattaaa gtagatggtg gaggtggagt
    73801 tgataaacta gagataaata taccagttga agctaaaaag gagcttcttg atagattgga
    73861 aaagaatata attatctttg gtcaaggagt taatccagaa tctcaaaaca caggtgacaa
    73921 atcgggtgta gcacttaaat ttttatattc actacttgac ttaaaatgtt ctaagactga
    73981 aaagaagttt aaaaaagcaa ttagagagct tttatggttt gtgtgtgagt atttaaagat
    74041 aagtggtaat aagagctatg attataaaac agttcaaatt acttttaatc actctatgat
    74101 aataaatgaa gctgaaaaga tagatatggc agctaaatca actggaattg tatcagatga
    74161 aactattgtt tctaaccatc cttgggtcga ggatgttaat gacgaacttg agagacttaa
    74221 aaaacaggaa gatactcaaa aagagtatga tgatttaatt cctaataatc aagatggtgt
    74281 tatagatgaa acataaagat tattggagga agagatttga acaattagaa gaagctcaga
    74341 ataataaaag tataaaatat tatcttgaat tagaaaaaca atataaacta gcaatgtcta
    74401 atatagaaaa agatatactt atatggtata acagattcac tgaaaatgag ggaatatctt
    74461 tattggaagc taagaaactg ctaaatacaa gagaactaga agagtttaaa tggagtgtag
    74521 aagaatatat taaatatggt aaagaaaatg ctataaatca aaagtggatg aaagagttag
    74581 aaaatgctag tgcaagagtt catataacaa ggcttgaagc tttaaaactg caaatacagc
    74641 aacaagtaga agttttatat ggaaatgaac ttgatggtat tgataaacta atgagagata
    74701 tttatacaag tggatactat catacagctt ttaatgttca acaaggagta aacgttggtt
    74761 ggagtttaat gagtcttgat actaacagaa taaataaagt tatttctaag ccttggacta
    74821 gtgatggatt aaactttagt gaaagaattt ggggtaagca tagacctgct ttaatcaatg
    74881 agttacatac taagctaact caatcaatta ttagaggtga aaatccaaaa gttttggtaa
    74941 atgaattttc taagaagttt aatgtatcta aatcacaagc taagaattta ataatgactg
    75001 aatcagcttt ctttgcatca gcttcaagaa aagattgttt taatgattta gatgtagaaa
    75061 agtatgagat tattgccaca ctagatttaa aaacatcaaa tatatgcaga gagttagatg
    75121 gaaaagtatt tgatatgaaa gattatcaag ttggaataac agctccacca tttcattgtc
    75181 attgcaggac aacaacagct ccttggttcg aggatgaaga aggttataga gcagcaagag
    75241 atgaaaatgg gaaaacatat tatgtgccat ctggtatgaa atataaagaa tggtatgaaa
    75301 agacatttat aactgataaa aaagatgata tactaagtaa taagagttgg ttaaaagcag
    75361 atttcccaac tgaaaagaaa tttaaaaagc atgtagaaaa acacttaaat gaatatggaa
    75421 atataactgc tgaagaatat ttatctactg caagaaattt gttatcagag caattaagta
    75481 atgatgtaga aggattttta agtaaagata actttttatt taaatataga aagagtacta
    75541 atgattttgc tgttggaaga gctgatggta aaatatcaac cttatttaag ccaaaagaag
    75601 gttataatta ctggctagaa caaataaaag aatataagga ggtttagaca tgaattgtcc
    75661 agtatgtggt aaagatgtag atgtatttga tatttgtgat aattgtaatt ggcaaaacag
    75721 tggaccaaaa gaaactaatt acaaaggacc aaataaaatg tcattaaaag aagctaaaga
    75781 ggcttatgaa aaaggtaaaa aagtaatata aaagcacttg ctaagttata aattagtagg
    75841 tgcttttatt atgtaaaaat ttattgcgag ggtgatttga aatgcttaaa ttatatctat
    75901 acttatttta tcaataattg tgttttgtac agggctttat ttattcaaca tgaaggttga
    75961 tagtaatgag gaattaattg aattacttaa aagtaagaat atcagaagaa gaaaaaaata
    76021 taattttatt ttcccagcgt tatttccact gcttaatttt attttaggtg tgatactgat
    76081 actatttttt ttactagtta gcaatgaaga tatgattaaa aatttaaagg gggataaata
    76141 atatggctaa atttaaaaag aaatcagagg aagtagaagc ttttaaatgg atattaggaa
    76201 gtcctaatac tcctatatgg ttttatcaag cttttgagaa gggaactata tggcttgatg
    76261 aatctttaaa ctctgtgaat cgtaaaggtg aagtaaagaa aactatctgt ataaaatata
    76321 aaaatggagt tattagggca actaatggag attggattat aaaagatagt gaaggtaaaa
    76381 tttattcttg tacatgtgat gaatttgaaa agtactataa ggatttggat aatgaaacaa
    76441 agatttctaa tggaggattg gaatgtttaa gagagatagc attaaaagat gtgaatttta
    76501 aatttgaact cacaggaatt aaggaggaaa aataaatgtt ttatctgttg ttacaagtaa
    76561 taagtatatg tttaagtatt acagtattta tgtatgttac aggtaatata gtctttaaaa
    76621 tctatcttaa aagtttaaga aaagaatatg agtctaatat acacgaagtt tctgatgaaa
    76681 ttttaaagag aataagaaaa gaattaaata aatcattaga tgaaagtctt taagaagttt
    76741 tttattaggt agaaaacaaa aggaggtttc tgttattgaa agaatatatg atttggttta
    76801 aaagcggcaa tagcatatct ggaatagtag acgaagatgt tgctgataag ttaatgcaag
    76861 attttatgga agctgactca gattgtaagg acttgaaagt atatttagat gaagatggaa
    76921 caacagtaat agatttatca caaatagaag ctatatcaat aaataattgt aatgagaata
    76981 ataatattgg ttttagtaag tcctagatag ggctttttta ttttgtaaaa aatgaaagga
    77041 gatatttaaa atggattggt taaaagaatt gctagaagga ataaaagtag aggataacaa
    77101 aattgatgta gcttctcttc aaaaatctat agaaaagaaa ataaaagaga ctacaattac
    77161 taaagaagat tatacaaatc ttgaaacaca acttaataca gctaatgaaa ctattaaaaa
    77221 gtttgaagga ggtatgacaa aagaagatgt agagaatcta aaaacaactt atgaaactga
    77281 taagaaaact ttggaagaaa cctacaaaaa agaaattgaa gaaaaggact ttaattactg
    77341 gttaaatgat gcttttaagt ctattaaatg tagggatgaa atagcgttaa aagctcattt
    77401 agatatagaa gcactaagaa atagtaaaga tagacaaaaa gcttttgaag agcaaataaa
    77461 ccctttgaaa caggataaag attatttgtt taatgcaaca ctagaaggtg aagagcctaa
    77521 aatagatact ataacaccag ggcaagagcc taagataaat gattttggtt ttaattttac
    77581 tggggtaaga cctcatgaaa ataataataa ataggaggaa ataaaatggc agcactaaat
    77641 tatgcaaaag aatattcaaa tgttttagca caagcatatc cttatacttt aaacttcggg
    77701 gatttgtatg caacaccaaa taatggaaga tatagatgga ctggttctaa aacaatagaa
    77761 ataccaacta tatctacaac tggaagagta gattcaaaca gagatacaat agcagtagct
    77821 caaagaaact atgataatgc ttgggaacct aaggtattaa ctaatcaaag gaaatggtca
    77881 acgttggttc atccagcaga tataaaccaa actaattatg tggcttcaat aggcaatata
    77941 acaaaagtat ataatgagga acaaaagttt ccagagatgg atgcttactg tatatctaaa
    78001 atatatgctg attggaccgc attaggtaac acagcagata caactgttct tacaacaaca
    78061 aacgtattag aagtatttga taagttaatg gaaaaaatga cagaagctag agtacctgaa
    78121 aatggaagaa tattgtatgt tactccagta gtaaatacac ttatcaaaaa tgcaaaagag
    78181 atacaaagaa cagtaaacat aaaagatggt ggaacttctt taaatagaca aaccacagat
    78241 attgatacag ttaaaataat taaagttcca tctaacctca tgaaaactgc atatgatttt
    78301 acaactggat ggaaagtagg agcaggagct aaacaaatct ttatgtcctt agttcaccca
    78361 agtgcaataa ttacacctgt ttcttatcag ttctctaagt tagacgaacc aacagcagtt
    78421 acagaaggaa aatacttcta ctttgaagaa agttttgagg atgtatttat attaaataaa
    78481 aaagctgatg caatacaatt tgttgttgaa ggagctggag cataatggca caagtaagaa
    78541 aattaaatag aatattaact atagaagaat gtaaaataga tgatttctta gagatgggat
    78601 atgatttgat agatgaaact ggtaaggcag taaagtatgg caagtcatta aatgtaaaag
    78661 atttaatagc tgaaaataat attttaaggt caaaagtcga gtctttagaa gaagaaaata
    78721 agcagcttaa agagaaaaat aagcttacta aaaagtaggt gaaaattgtg gaaaataata
    78781 tgattgatga tatagaaaga agacttcaag gatttggata tgttctaaag gatggagata
    78841 aatggttaat agattttgta agagaaaaaa tagaaaatat tattaaacta gattgtaata
    78901 taagtgaaat tccaaaagag ttacacaata tagaaataga tatgatagct ggagagttct
    78961 tatttaccaa gaaaaatatg gggcaattag atatagaaag tattaacttt gaagctgtag
    79021 aaaagtctat atcagaaggt gatacaaagg tagattttgc tataggaagt ggctctcaaa
    79081 caccagaaca acgctttgat agcttagtag cttatcttac tacttatggt aagaataata
    79141 tattaacctt taggtgctta agatggtaag taaaactaga aaagcaatag aaatgttata
    79201 tagagataaa tgtactatag ttgagtatca gccaattaaa gaccctgtaa caaaacgaac
    79261 taacaataaa gaagtgattg tattagaaaa tcaaccatgt aaactttcat ataaaaatat
    79321 tacatcagct acagatggaa aagtagctaa gctagagcaa actattaaac tctttatatc
    79381 accaaacata gaaattaaag caggttcaaa acttattata aatgataaag aatatgtaag
    79441 aagtggagaa tctgcgttat atccaaatca tcaagaaata atacttgagc tatttaagga
    79501 taaagcataa tggctagatg gggcagtgtt gattttagag agtttaaaag agtttgtaaa
    79561 aagatggaga agcttacaaa gattgattta gataagtttt gcaaggatgc agcaaaagaa
    79621 ttagcagcaa gattaattgg caaagctata aaacgtacac cagttgatac aggattctta
    79681 cgacaaggat ggagtggagt ggcttatgct aggtcgcttc ctgtgtataa acaaggaaat
    79741 aattatatta tagaggttgt taatccgact gaatatgcct taacacaatg gggcatataa
    79801 aacccagcaa aatcggtaaa cgctaagtgt aatagtgtta cattataaag taggtagaat
    79861 atggacatag aataactctt gatttataat gtataaaaga ggtgatttta tggcaaaatt
    79921 tttagatatt acaggaaaaa aatttggaag gctaagagtc attaaatttt ctaaagagat
    79981 aaaaagtggt aaaagaaata gaaaatattg gttatgtaag tgtgattgtg gaaatttcaa
    80041 agaaataaga actgactctt taactagtgg cttagtacaa tcttgtggat gtttaaaaaa
    80101 agaacaagat aaattaaatt taacagacaa ataccaattt aaaaagaaat ataaggttca
    80161 aaataaaaga ctttacagta tatggaaggg tataatatct agatgtacag ataaaaataa
    80221 taaaagatac aatagatatg gtgaaaggaa tataattgtg tgtgatgaat ggttttgcta
    80281 tgataatttt gcaaattggg cattgagtaa tggatattca gagaaactta caattgatag
    80341 aataaataat gaaggaaatt atgaatcaag caattgtaga tgggtggata taaagacaca
    80401 atgtagaaat aggtcaacaa atatattagt aaagcatgaa gaaaaagaaa ttacattgat
    80461 agagctttct gaaaaaacag gtatttcata ttcttgctta agaagtagat attctaaggg
    80521 attagtagga aataatctta tagaaaaagt taagattatt gaagaaagca gagctaagtt
    80581 atctattgag gatgtaaaag aaattagaaa aaagtattct gatggatata caataaaaca
    80641 actaagtgaa atatatcctg taacatattc atctatatca aatatagtcc atagaagaac
    80701 atggaaaaat atttaattaa ttatatatgc caataccgag gaaaacctat agattgcgaa
    80761 taggctatag gtttccgtag agcgtagaga gtgaataaat ataatctctc caagagtgct
    80821 gggcaactaa ataaagttta ttttgttgat gatgtacgcc gaacttatag gaaactataa
    80881 gagctagagg ataaaaagcc tttaggataa caaaatgcat atgttgaata tggccataga
    80941 actaaagatg gaaaaggttg ggttaaagga caacatttct taacaatttc agagatggaa
    81001 ctacaaagcc aagttgataa gattatagag aaaaaactat taatattgct taaaggagta
    81061 tttgatgctt aataatataa ttgatggaat atctattaaa ttagataaaa catttggaga
    81121 gagttataca atttatagtg aagatgtgga gcaaggtata aatgaacctt gtttttttat
    81181 tgttccttta aatccaagca aagtatccta tccaagtggc aggacattaa aaaagaactc
    81241 ttttgatgta cattattttc caaaaagtaa tgataaatca tttgaaatag atgaggtagc
    81301 tgagatgcta ctggaggaat tagagtatat agaaattgat ggagatttag tcagaggtac
    81361 aaatatgaac tttgaaattg tagataatgt acttcatttc tttgttgatt ataactactt
    81421 tactataaaa aataatgata tcaataagat ggatacagta gagttattcg gtggtttgaa
    81481 gagaggtgat aattttgagt aagacattaa gtaaaggaac cgattacaag tttactaagg
    81541 agcagatagt taattctaag aagtatataa atagaaaaga cttattaaat gcaattttaa
    81601 aagaaaatga gttatattcc ttctcagagg tagaggaaat aataaatagc tttatgaaag
    81661 gagtgagtta atttggcgtt aggtggagga acatttgtaa cacagaataa aatattacca
    81721 ggtagctata taaattttat ctcagctaag agggcaacca gttcattatc ggatagaggt
    81781 attgttgcaa tacctttaga gttagattgg ggcatagatg aagacgtatt tcaagtaacc
    81841 agtgatgatt ttgagaagta ttcagtgaag tattttggat atgattatac tcatgagaag
    81901 ctgaaaggtt tgagagattt attcaaaaat ataaggttgg gatattttta taaattaaat
    81961 aaaggcgtta aagccagttg tactatagcc acagcaaaat atagtggtat cagaggaaat
    82021 gacttaaaag taacagttac aacaaatata gatgataatg ctaagtttga tgttgtaaca
    82081 cttttagata ataagaaggt agatactcaa atagcaaagg ttattacaga cttacaagac
    82141 aatgactata tcacttggaa gaaggatgca acactagaag caagtgcagg acttgtattt
    82201 actggtggaa ctaatggcga agctgtgaca ggagcagagt accaagcttt cttggataaa
    82261 atagaaagct atagctttaa tgctttagga tgtttggcta caacaacaga aattaaaagt
    82321 ttatttgtag aatttacaaa gagaatgaga gataaggtag gagctaagtt tcaaacagta
    82381 ctatataaga aaagtgatgc agattatgaa ggtgtagtgt ctgtagaaaa taagattaaa
    82441 gatattggat tagtagaatc tagtttaatt tattgggcgg ctggagttat agcaggatgc
    82501 gatataaata aatctaatac taataaaaag tatgatggtg agtttgatgt tgatgttaat
    82561 tatacacaaa tacaacttga agaagcttta aaaactggta aatttatatt ccacaaggtg
    82621 ggagatgaag ttcatgtgtt agaggatata aatacttttg tatcatttac agatgataaa
    82681 aatgacgatt tttcaagtaa ccaaagtgtt agagtacttg accaaattgc taatgatatt
    82741 gcaactttat ttaatgaaaa gtatttaggt aaagttccga atgataaggc aggaagaata
    82801 agtttctgga atgatgttgt taaacaccat aaagaattag agaatataag ggcaatagaa
    82861 gattttaaaa ctgatgatgt tagtgtagag cttggaaatg ataagaaaac tgtcatagta
    82921 tctgatgctg ttaaggtaat aaatgctatg agtaagcttt atatgactgt ttcagttaat
    82981 tagagaggag agtgataata tggctcaaac aataaatgct aaagatacag ttagtgcaaa
    83041 gaaagctgaa tgttttataa ctatagaagg taaaagatat aattttatgc aagctataga
    83101 tttagaggct aaaatggaaa aaaataaaag tgaagttcca attctaggaa gaacaacaaa
    83161 gggaaataaa acaactggga gtacaaatac tggaagtgca acatttcatt ataatacttc
    83221 tatttttaga gaattacttt acagatataa agaaactggt gaggatattt attttgacat
    83281 acaagttaca aatgaagacc ctacatctgc tgtaggaaga cagacagtag tacttaaaga
    83341 ttgtaatatg gacagtggaa taattactaa atttgatgct gatggtgagt atttagatga
    83401 agatatggat ttcacttttg aggattggga attagtagaa aaatttaatt tattggcagg
    83461 aatggagtaa aatacacatt tataaattat atatgtgtat tttttatatg aaaaattaaa
    83521 ataaaaggag attagaataa tatgagtaat ttaagtgctt ttttaagtca aaatgcaata
    83581 aaggttgata atgtaaaata tgtagcgagt aacagatttt tagataaaga agggaaacca
    83641 gttgaatggg aattaaaagt tttatcatct gaagaagacg aagcactaag aagaaagtgt
    83701 actaaaagag taaaagtgat tggtaacaat ggtaagcata ctggacaata tacaagtgaa
    83761 attgactaca atagttatgt agctgaatta tgtgtagcat ctacagtatt tccagattta
    83821 aaggatgccg aactccaaaa tagttatgga gtaatgggag aagctcagtt attaaagaca
    83881 atgcttacag caggtgagta tgtcaattat acagtaaaag tgaatgaagt caatggattt
    83941 gatacatctt ttgaggataa agtagaagaa gcaaaaaact aatcagaggt ggcgattttg
    84001 atgctagcat cactcattat tgtattcaaa aattaaagtg gaagccaagt gaatatatga
    84061 atttagaagt taatgagaga gcgttagcag ccgcctcaat acttataaag atagaagatg
    84121 aagaggaagc aatgaaagaa gctgaaagag agagaaagag gggacgaaga agatagcaaa
    84181 ataaaaaaat aaatatagaa taggtaaaat atgtaataat tatatgttat aatattttta
    84241 gcaagaagat gtaatctaca atttatagag tggagttcat actgggataa aacctacttc
    84301 ctaatgaaag gaggtgggaa gtatgaataa ctttttactt aatgtaatag ctggcgttat
    84361 tgctagttta atattttgct taatttgtaa agtatttcta aaagtaaaaa gccactcaac
    84421 tcgtggcaag agtaaaagtg gctgggaatt tgattttaaa atcaagttcc ataagttcaa
    84481 atagattcat ttaattatga acttcactct accgcaaaat agattgtagt tcttcttgct
    84541 tttattatac cacaaattag aaaaaatatt gtttatataa aataaaaaat aaaaattttt
    84601 attaaaaaat tgaaaacttg attataaagc aattaattta taaaatatat ataaataagt
    84661 aggtatttat ttacttgaat ttcattgttt atataaaaaa aatggaaaaa tatgtaataa
    84721 ttatatgtta taataattgt agcaaggata ataatcgaaa gtgcgaaggg tgattatttt
    84781 catattaaac gccaaattcc aaataaggaa ggaggtgaaa ttatatgata ggttttttat
    84841 taagcatact agctggtgtt atatcagctt atatttatga caaaataaaa aatcacccag
    84901 acgccaataa gggtgattta aaaaaataat tctttaaatc aattttgatg gaaatagcta
    84961 ctcttgtata aagtaaatta tttccttgct tttattatac cacaaattgg tacagatatt
    85021 caaaaataat atttttatga tataataaaa atgtagagat tttgcagtga gcaatatttg
    85081 cgataaattg aagtttaaca attggaatac aaggtattga gggtgtgtga taaatgttat
    85141 caattgcact actcatggtt cactgcaaat ttgagagaga tgcgtatgtg taggtattgg
    85201 aaatgccaag tttattttgg ggttttagat taactatgtg gtatgtaaat ttactagaag
    85261 gaacatcaaa aggaggttta aaatccggtt ttagattaac tatgtggtat gtaaatccaa
    85321 ctaggtgaaa gaagtttacc caaaatatca cccgttttag attaactatg tggtatgtaa
    85381 atgttacaga aaaaagtata acagaagctt ctaatatagg ttttatatta actatgtggt
    85441 atgtaaagct ttatcatcta aagctattac actaaatctt agacacattt tatattaact
    85501 atgtggtatg taaatactga aaacataaaa gatgctatga ttagagtaag gttttagatt
    85561 aactatatgg aatgtaaatg aattttcaac acgctgtgct atcttagtta ctcctagttt
    85621 tatattaact atatggaatg taaatacaga aagtgtaaaa gatactatga ttagagtaag
    85681 aggtttttat attaactatg tggtatgtaa attctttata agttacctat atatttaacc
    85741 acttcgtcgt tttatattaa ctatgtgaat tcaaaattaa atagaaaaaa gaaagcactt
    85801 acttaaatag taggtgcttt tgttttgctt atagcttttc atcatcttca tattccataa
    85861 tatctcctgg ttgacagtct aaagctttac atattttatc aataacatca agggaaacat
    85921 ttttatttga agataatttt gctattgtgg tagaagaagc tcctattttt aatcttagtt
    85981 cttctttagt tatacctctt ctgtttagta agttaattag tttgaaaaat tttatagaca
    86041 tgttaatacc tcctatatat ttatataata ctatatatct ttattaaag
//
LOCUS       DAEHWM010000003        76042 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.003, whole genome shotgun sequence.
ACCESSION   DAEHWM010000003 DAEHWM010000000
VERSION     DAEHWM010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 76042)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 76042)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..76042
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.003"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(139..2094)
                     /locus_tag="KNP36_000249"
     CDS             complement(139..2094)
                     /locus_tag="KNP36_000249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872146.1"
                     /translation="MKKYEIFIFMSIIVLCFISFPHKVFGQEENCLEDFERWVQENKN
                     NKEEIVYTLSCDMVIDEEFRFYIPYDSNFTIDTNKYKILIKNHGRFIIDDNELNIIGE
                     GGKEGVIHIENGGSISIGINNIIATDGTALYVEEGGDLHIKSSYESVEKIKANGKDAI
                     GIYTENDIRILNKDIEVNGEHAIGVYSKGDVEIEETSIKAYSSNNESGLLKDNNKLAQ
                     SIISESKKVYIIDDYNELIPSIAEDSGYDIVKCCHRGIGVFSDEIKVSKDDKIENIKF
                     PKYMVLETSSGNRLDIDVEWDFTDYYEKLEKGENFNITGKFKTEMLNKEKIIINDDVV
                     PILNVSVIEKKPIDNLELEFQNTKNGYVAVLFYDMPYSASKVFVEYSSDGINWISEEQ
                     EDIRDQAILFFEDFKLRCFRVKVVGGLKEGYSNIVFKPGFIMGGGDNQETPDDEREND
                     DIDGDRGGGGRDDPDRDEDDNNQDGNNGNENNDSNNNQNNNNENNNNENDNSDEKQPN
                     TPKDDVESSTDSNENKNPHDIPKDGNKENNSDKEKGFYNKNSITENDDNYDLSSKLVF
                     GTNEHSFPYRESISNKNQDTNKNKSNISDYDGIINNNYKLESKEYNLKKDIIFLFCIL
                     TPIMIGSILIVNPDTRKSIIKFIKLKK"
     gene            complement(2277..3752)
                     /gene="spoIVA"
                     /locus_tag="KNP36_000250"
     CDS             complement(2277..3752)
                     /gene="spoIVA"
                     /locus_tag="KNP36_000250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage IV sporulation protein A"
                     /protein_id="HBF0872147.1"
                     /translation="MNNNIYEDISKRTQGDIYIGVVGPVRTGKSTFIRKFMEKLVIPN
                     IDNEFKKDRTRDEIPQSGSGKTIMTVEPKFVPADGVEIKIKDTVSLKVRMVDCVGYIV
                     EGALGHEEGGKQRLVSTPWSQEAMTFEKAAEIGTKKVIKDHSTIGIVVLTDGSVTGID
                     RKSYVEPEERVIQELKNLKKPFAVVLNTLSPKSEETSMLRSELEEKYEVPVLPMNVVE
                     MEEEDIEEVMEAVLYDFPLTEIRINLPKWVEGLERNHWIKSSIITTLKQSIIDIGKIR
                     DIEGIIQGFSELEFLEDTGVDNVELGEGVINIDLQTKQDLFYNVLEEKSGFKIEGDYQ
                     LLSLITRLSKVKNEYDKIESALIDAKIKGYGVVAPSLEELSLEEPEIMKQGKQYGIKL
                     KANAPSLHIIKADISTEVSPIVGNQNQGEEMIKYLMEVFEEQPADLWESNMFGKSLHD
                     LVKEQLQSKLYTMPEEIRVKMQKTLQKIVNEGSSNIITILL"
     gene            complement(3924..5219)
                     /locus_tag="KNP36_000251"
     CDS             complement(3924..5219)
                     /locus_tag="KNP36_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0872148.1"
                     /translation="MSVEVNKPSIWKNFKVLIILFVAGAFIYALPYLKNYYYDTFAQA
                     FNLTNTQMGSLGSIYGLLAMVSYLFGGFLADRISARKLLSGSLIITGISGLVLTLYPP
                     YIVVFLIHALWGITTILTFWPALVKAVRMLASENEQGKAFGFMESGRGITNAIHLSLV
                     LILFGYISSKVSDESGLTAIIVLYSAINVIVGVLVFFKLKDNEKEVSAKFDKEAFFAV
                     IKMPHTWIITIIMFCSYSANMSFYYFTPYSTEAFGATVVFASAISILAQYCRPVASAA
                     SGLLGDKVGSSKIISYGFILMIAGLLGVIFTPTKSSMIYILLIGCVAIYVSMYAIQGL
                     HYSLLEEGNYSLSISGTAIGIVATLGYLPEVLCPLAAGKILDAFPGVTGYRYYFIVLT
                     IVAIIGLVFTFIWMNMTKERCKELIEMNNNSNENTTKVS"
     gene            complement(5403..6812)
                     /locus_tag="KNP36_000252"
     CDS             complement(5403..6812)
                     /locus_tag="KNP36_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0872149.1"
                     /translation="MKKKIGFWDLVFMNISALFGIRWIAKSTASSFGLGLGSIPVWLL
                     FAFIFFVPASLICAELAATYPKDGGLGEWVKQAYGEKWGFMVSWLNWTSKIFWYSSFL
                     TFLAINIAYMLGNPDLSNNKMFILALSLIIFWLLSLVSTRGMAFGKFFTNTGALGSTI
                     PAILLIVMAFMSVVILKKAPSASIYTIQNIIPKIDANSLVSISAIIFALSGAETTANF
                     ITEMDNAKKNFPKAILTVAVLIGGIYILGSVAITMILPPDKIAASTGILDALAKVAQD
                     LGIGSWFIRIVAFGITLSVLGALILYIAGPVKMLFGNVREGVFPKQLTVTNKYNIPSN
                     AVIVQAIIVSLLLVGTNLLPSVDNIYNVLVTMTALTALFPYVLLFTSYIRLRKTRPNE
                     ERPYSIAKSDSVCINIARMVLVVTVVGILFSTAPVMETLKDNIIYEIEMIGGGLFVII
                     TGLMLWKNYEKKISNNSGC"
     gene            complement(6864..8003)
                     /locus_tag="KNP36_000253"
     CDS             complement(6864..8003)
                     /locus_tag="KNP36_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0872150.1"
                     /translation="MSNNMRLERLRKYMNEKSIEIALIFEPDNQFYISGFKAITYSRP
                     IVTVVTQDKIELIVPGLEELHAKEVAKVDNVYVYYEIPEMKEHGISHKHYLDIILNKY
                     PKGTTVGIEKDIVSASFSEYITDKSFAIKDVGSKIFEMRYVKDAKEIEFLKIAGYLSD
                     IGIKGSLENVRVGMSELEFDVAGDNALLKYVSENYPDTYIGFANWTCSGIDRTAQPHL
                     DSNTRILQRGDIVIHSRQVWYENYRAENERTFIIGKPTERQKEVFKIAVEAQQAGLDT
                     IKAGIPARMVDEAARAVVAKYGLELYSNHRIGHGLGLSEHEEPYLRFDNELILEEGMV
                     FSMEPGIYIPGVGGFRHSDTAIVGKNGATIITNYPRSVEELILDI"
     gene            8322..8972
                     /locus_tag="KNP36_000254"
     CDS             8322..8972
                     /locus_tag="KNP36_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0872151.1"
                     /translation="MTNKELQKKRILMYFIEAAQNIMENEGIENITLRKVADMAGYNS
                     STLYKYFKNLDHLISFASIKYFKDYNLNISRCIENVNDEYKKYIIMWKLFCKHSFDNA
                     QAFYQVFFNLSSDELSYITKQYYDMFPEDLGIHDSDISLMITGESIKERNKILLNNLV
                     DTGYIPAKDLDIINDIIISFYQNLLFLKKNTGKNSDDDELTMKMISSIEYIIKHAK"
     gene            complement(9129..10148)
                     /locus_tag="KNP36_000255"
     CDS             complement(9129..10148)
                     /locus_tag="KNP36_000255"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HBF0872152.1"
                     /translation="MEKVCVLGTGSWGSALALGLAKKGNDVSMWTRKEEQAKKINRTK
                     ENTDYLPGVLFPNNITISTDIEKTIKDCKVIVLAVPSQAVRSTCQKIKPFIKEGQVIV
                     NVAKGLEKGTGLRLSQVCEEELPQNPYVILSGPSHAEEVARDIPTTVVVASKDLKIAQ
                     MIQDLFMSPKLRVYTNPDIVGVELGGALKNIIAFGAGICDGLGYGDNAKAALMTRGIS
                     EMSRLGIAMGANMSTFAGLSGIGDLIVTCTSMHSRNRRAGILIGKGMSLEDTLKEVKM
                     VVEGITATEVAHDVAEKLDIDMPITNAIYSVIKKGSNPKEVGIELMMRSKKHEMEEVV
                     LGDDI"
     gene            complement(10179..10793)
                     /gene="plsY"
                     /locus_tag="KNP36_000256"
     CDS             complement(10179..10793)
                     /gene="plsY"
                     /locus_tag="KNP36_000256"
                     /EC_number="2.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HBF0872153.1"
                     /translation="MEIFSYIIIAVVAYLLGNISTSYIVAKRIAGVDIRTQGSGNAGS
                     TNVLRTLGKRAGAMTFLGDVLKGVMAVLISEFAARLVGIDTLLAGYLAVICVVAGHNW
                     PAVLGFRGGKGVATSLGAMLAVNPVITLMCLAVFILVVAITKYVSLGSVVGIGCSPIF
                     MIMVKNKAGLIVALFLTASVIYNHRANIKRLLNGTERKIGQKKE"
     gene            complement(10828..12147)
                     /gene="der"
                     /locus_tag="KNP36_000257"
     CDS             complement(10828..12147)
                     /gene="der"
                     /locus_tag="KNP36_000257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HBF0872154.1"
                     /translation="MSRPVVAVVGRPNVGKSTIFNKFAGKRISIVENTPGVTRDRIFA
                     EVEWLDKYFTLVDTGGIEPDSEDIILSQMRNQAMLAMDMSHVILFIVDGKAGITAADK
                     EIAQLLRKTKKPVILVVNKIDSQSQFDNIYDFYELGFGTPFAVSGANSMGFGDLLDEI
                     VENFPAGLDTEYEEDIIRVAITGKPNAGKSSILNKILGEERVIVSPIAGTTRDAIDTY
                     FEKNGQKFLLIDTAGLRRKSKIYETIEKYSVIRAMSAVDRADVVLIVIDALEGVTEQD
                     TKVAGIAHDEGKGCIFVINKWDLIEKDNKTMSNYTKDIKEKFPFMMYAPIVFVSAKTN
                     QRMNKILDTVEYVSNEHSKRISTSALNEVIGEAVMLNQPPSDKGRRLKIYYGTQTDIR
                     PPKITLFINDKDLTHFSYQRYLENKIRENFGFEGTSIKFEYRQKNKK"
     gene            complement(12181..13509)
                     /locus_tag="KNP36_000258"
     CDS             complement(12181..13509)
                     /locus_tag="KNP36_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF512 domain-containing protein"
                     /protein_id="HBF0872155.1"
                     /translation="MEVNVKKVNNIISKVYKDSIAEEMGIEVGDLLISVNEQPIHDII
                     EYRFLLSDEYLDVEIQKKDGEVYIYEIEKDYDEDLGVEFTNPIIDQAKSCRNKCMFCF
                     IDQLPEGMRETLYFKDDDSRLSFLQGNFVTLTNMSEEDINNIIKYRISPINISVHTTN
                     PELRQKMISNKFAGKLYGIMKRLADAHIEMNCQIVLCPGINDGKELDRTIKELAQLYP
                     YVNSVAIVPVGITKHRENLVELNIFNDKSASKTIEQIHQIQQKYLEKLGTRFAFLSDE
                     FYILSNSELPGYEEYEGFLQFEDGVGMIRKLKTEIEEYLNILPEKILKREKKVSIATG
                     HSAYEFIQSMADAMMDKFKNLQVNVYEIKNKFFGETITVSGLLTAKDLKEQLEDKELG
                     EALYITRSMLKADEEIFLDNIELNQLEELMRIKIIPCLNEGKDFVDKILK"
     gene            complement(13747..13947)
                     /locus_tag="KNP36_000259"
     CDS             complement(13747..13947)
                     /locus_tag="KNP36_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872156.1"
                     /translation="MGMDIGLNEYTLAIVTLDKNMKNGGGCPIFYANDEKDLQNKALL
                     MSKCVGGMVHDMTNGTLIIVKH"
     gene            complement(13949..14881)
                     /locus_tag="KNP36_000260"
     CDS             complement(13949..14881)
                     /locus_tag="KNP36_000260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426964.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YIEGIA family protein"
                     /protein_id="HBF0872157.1"
                     /translation="MDRVFFVAVIIGITSRIIMLNLDQKQYPTQPNVLLSQLILAFVA
                     SSLGALLVPALINRSYTSITFLSLAAEQFRQVRANRRNTLQNLEEVQLVKRGAAFIEE
                     IARTYEVRNYMCIVTSFLTIGLYYVILAETKISEGMSLVISSICGLVLAFILKKLLTR
                     KSIGDIADVMPAEISFVDESILKVGDLKGITNIGLKSDREVYINRGVGIQIIPKNKDY
                     ANAGILFDSGQRQAIVYNIYSRLGLYGDYGEPSFVPLPRRNKEDESIMIAYLPVDKNV
                     EKVMEAVKSCPILSSSKGKNLSLKNYKIGKKGSA"
     gene            complement(14926..15858)
                     /locus_tag="KNP36_000261"
     CDS             complement(14926..15858)
                     /locus_tag="KNP36_000261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YIEGIA family protein"
                     /protein_id="HBF0872158.1"
                     /translation="MEESLLNANLFRHSFIVALVVGILCRGLVLRVTDKQYPSRPQDY
                     LEQIIISGLSASLGAIALPALIDKEFAALTFFAVAIQQFQGLAEQERITLKNIDNEEL
                     VPKGDAYVEEIASTYESRSYISLFSALVSSIVYIVFARKYGLSFFYCTILAIVSGAIV
                     GLIFRRFLRRNSIADIADIVPAKISFEGPILMVNGVIITNIGLESTREKYRNECLAIE
                     VIPRDLGAFGIVNDIGQRQAIIHNLFIHMGIDRDVDEVDIVAISKTNLEKSTVVIPYM
                     PILKDIDVMIDVVKSTPIIETSKGKQSDFSRKTL"
     gene            complement(15913..17202)
                     /locus_tag="KNP36_000262"
     CDS             complement(15913..17202)
                     /locus_tag="KNP36_000262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872159.1"
                     /translation="MEDLNSIYFFIVMLSIAIVILAVRYTITLRKYLKEFIYVSKKVS
                     NNEYHARLNISAKGELGELARNFNHMIKNMDKTLEEVQYKHLQLRSILKSISHGILAI
                     DVNGNILLINDEAKEMIKSEPNQLVEGHNINVVIKEEEILKQILQFIGSKDNETANIT
                     TKDDIVYKIKVDPVYLQNTNNVIIGSIVNIEDITKKVKLENMRSDFVANVSHELKTPL
                     TSISGFVETLKSNENIDVNTRNRFLEIIESESDRLKRLIDDILLLSFVENKDTLLMEN
                     VVVYDVFKEVYEITQHSASEKNIEVLYKCDDKSISILSNKDYIKQVFLNLVDNAIKYT
                     QDNGIVQVVVLKDEEKIVIKVIDNGVGIPKEDVERIFERFYRVDKARSRDVGGTGLGL
                     AITKHIVKSLNGCIKVKSELGIGSEFIVTILQKNFLK"
     gene            complement(17231..17923)
                     /locus_tag="KNP36_000263"
     CDS             complement(17231..17923)
                     /locus_tag="KNP36_000263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872160.1"
                     /translation="MNTKVLVIDDEMHIVELLKFNLEVSNYEVSYSYDGFDGFIKAKE
                     IKPDLILLDWMLPNISGIEVLRKIRSDKDLKNIPVIMLTAKNMENDKVEGLEIGADDY
                     ITKPFSIKELLARISSVLRRYNLTSLGEENNILTTGNLKLDLSKHEVTKGSEKIELTL
                     KEFELLKLLIQNKGKVLSRNYLLDKIWGYEYYGETRTVDVHIRYLRKKIEDEDKSEKY
                     IETIRGVGYKID"
     gene            complement(17938..18699)
                     /gene="pgeF"
                     /locus_tag="KNP36_000264"
     CDS             complement(17938..18699)
                     /gene="pgeF"
                     /locus_tag="KNP36_000264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan editing factor PgeF"
                     /protein_id="HBF0872161.1"
                     /translation="MMKDYINIKNVQDIKEYVNLSGNCEELDEKLNSVNLVITCKNID
                     AKNREDMLKVCKECDLTFENLTSNSQIHSDIVNIVNKDTIGKRRDGDALITNLEKVPL
                     LLFTADCVPISIIDAKNKAIGLAHAGWRGTFSNIGHKTIKLMSECYKTVPEDLVCIIG
                     PSIGPCCYEVSEDLVEKFNTILTNNDEKFYIIKEGSYYLDLWKINEYMLRCSGVKKEN
                     IINLNLCTSCRADKFHSYRKHNKASERIGTVLQIK"
     gene            complement(18696..19157)
                     /gene="nrdR"
                     /locus_tag="KNP36_000265"
     CDS             complement(18696..19157)
                     /gene="nrdR"
                     /locus_tag="KNP36_000265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HBF0872162.1"
                     /translation="MQCPYCNYKESKVIDSRHTDLKSIRRRRECESCKKRFTTYEKIE
                     TTPLMVIKKDNSREYFDREKIKYGLLKACEKRPVSIDEIESIVVHIENEINKCFIEEI
                     ETKKIGEMVMDKLKELDEVAYVRFASVYRQFKDINTFVNELKSILIEKGDK"
     gene            complement(19179..19442)
                     /locus_tag="KNP36_000266"
     CDS             complement(19179..19442)
                     /locus_tag="KNP36_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="HBF0872163.1"
                     /translation="MIRVSDIMEKEIINVKNGKRMGFIIDIDMDIHEGKVVSFTIFGD
                     GSRSFFSRGGDEEVIFWNDILKIGCDTIIVNIGSELSLDEFEI"
     gene            complement(19546..20319)
                     /gene="sigG"
                     /locus_tag="KNP36_000267"
     CDS             complement(19546..20319)
                     /gene="sigG"
                     /locus_tag="KNP36_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigG"
                     /protein_id="HBF0872164.1"
                     /translation="MQVNKVEICGVNTSELPVLKNKQMKELLLQIKNGDEEARQQFVR
                     GNLRLVLSVIKKFNNRGENIDDLFQIGCIGLIKAIDNFDLSQNVRFSTYAVPMIIGEI
                     RRYLRDNNPIRVSRSLKDIAYKALQVRERLIRTNSKEPTVSEIAKELELEVESVVMAL
                     DAIQDPISLFDPVYQDNGDAIFVMDQVQDKKDTDENWLQEISLKEAIKKLNSREKLVL
                     DLRFYKGRTQIEVADEIGISQAQVSRIEKNALKNMRKYV"
     gene            complement(20411..21133)
                     /gene="sigE"
                     /locus_tag="KNP36_000268"
     CDS             complement(20411..21133)
                     /gene="sigE"
                     /locus_tag="KNP36_000268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigE"
                     /protein_id="HBF0872165.1"
                     /translation="MLRLKERIISFITMLGIKLKIIKPKGIYYMGGANILPPPLKPEE
                     EMELLQKLETDESVKSILIERNLRLVVYISRKFENTGIDVEDLISIGTIGLIKAVNTF
                     KLNKNIKLATYASRCIENEILMYLRKNNKKKTEVSFDEPLNIDLDGNELLLSDVLGTE
                     NDEIYKIIEEEIDRDLLVMALDRLSDREKQIMELRFGLIDKGIEKTQKEVAGMLGISQ
                     SYISRLEKKIISRLQKEMKKFV"
     gene            complement(21158..22030)
                     /locus_tag="KNP36_000269"
     CDS             complement(21158..22030)
                     /locus_tag="KNP36_000269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-E processing peptidase SpoIIGA"
                     /protein_id="HBF0872166.1"
                     /translation="MFKGFKGGYMVYIEYYVIENLVINYIIISCTSILTKRYNPKKNK
                     LLGASLGGAYSVAYLYPSMNILFTVPFKIIIMSIITLISFRSKSKKDYVHVALVFYLV
                     NIFISGSTYFIIYFTGISHLKISFLIACTYVSCELLKYIYKDLKMLKYIKELTKTINI
                     NLLEKSFCCKALVDSGNLLKDPISQSDVIIVKSSVLEGFIPEKLLNINYEDIDMKKAQ
                     EIIGSLDDKTSGRVRIIPYKHAGSNKTSIIIGLKADYIEVDEQKIGNIILGISNFNDR
                     EYGAIMNPNILPGF"
     gene            complement(22320..23594)
                     /locus_tag="KNP36_000270"
     CDS             complement(22320..23594)
                     /locus_tag="KNP36_000270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBF0872167.1"
                     /translation="MIKLKKVLSLVMVGILSVSILAGCSKKEDSKGKEGKEKLVVWSA
                     PLTDHDADAWKPIFEKFEKENNCEIEFQIVPWDNYAEKYATAISAGEGPDIGYMYAEM
                     FPQFIEMGAVEDLTPYLEKSGTSDNYLYLDDAKMMGGIYGLPIEAANPGVLYYNKDIL
                     EKLGEKPPKTWDDFKRICEKATKDTDGDGKIDQWGLAQGWGSKVFGSLNWNWYPYLWQ
                     AGGDIYNDDLKSVKFNNAEGLKAANFINDMKKYIPEDALSKDSNEMIESVFGPGKAAF
                     TIMLSSAATSTFDKSFPDLNWGYVTSLEDKTVGSFASVDDLTLMSACKNKELGFKLLE
                     YMLSKESMEAFHKEIPRAPVAKGEKYQGDPRFEEMVTRDKHMYRPLTVGPHGVEIYEY
                     LWKQLQMMIAGDITPEQALNESAKYANGLLAQ"
     gene            complement(23878..25035)
                     /gene="ftsZ"
                     /locus_tag="KNP36_000271"
     CDS             complement(23878..25035)
                     /gene="ftsZ"
                     /locus_tag="KNP36_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HBF0872168.1"
                     /translation="MLNFDVELEECAQIKVIGVGGGGNNAVNRMVEAQLKGVEFISVN
                     TDKQALYTSKAEYKVQIGEKLTRGLGAGANPEVGKRAAEESKDEIVKLLQGADMVFVT
                     AGMGGGTGTGAAPVVAGLAKEMGILTVGVVTKPFAFEGKIRMKNAEGGIAELKSKVDT
                     LITIPNDRLLQIVQKNTSMLDAFAVADDVLKQGIQSISDLIAVEGLINLDFADVTTIM
                     KDKGLAHMGIGSASGETRAIDAARQAIQSPLLETSIQGAKGVLLNVTGGPNLGLFEVN
                     EASTLVMESCDPEANVIFGASIKEDLGDEIMITVIATGFEGLQNGALDLDTKPKSSIR
                     SSLNTTVKQAVKEIEEEVIAEEKIEPPKKASIIEEDDDESMEIPTFLRRRR"
     gene            complement(25225..25578)
                     /locus_tag="KNP36_000272"
     CDS             complement(25225..25578)
                     /locus_tag="KNP36_000272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small basic family protein"
                     /protein_id="HBF0872169.1"
                     /translation="MLWVLGGLAFGVVVGYYIPFTYSMDYSIYMSVAILAIMDSIFGA
                     IKSNFEDNYDNVIFITGFIGNAILAILLTYIGEKLGVSLYYVAVLVFGMRLFNNLSII
                     RRYIISNIMNKKRKN"
     gene            complement(25677..26351)
                     /locus_tag="KNP36_000273"
     CDS             complement(25677..26351)
                     /locus_tag="KNP36_000273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728479.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBF0872170.1"
                     /translation="MKKKIVILGAFILGVFISTYIKSLDPNRVYITLGQTESIESEVE
                     NTKKEIKNLKETLKNNKKTLNEYKEAKKNGNESIQTLMQKELEEVKELSGYSTVTGPG
                     ITITMRDSERELKDGQNPNDLIIHDIDILRVLNDLKKAGARAISINGERVLATSKIKC
                     SGATITVNDTTYGQPFIIKAIGDIDLLSAAINSPESYAKSLKDIYGINIKVQENNGNK
                     VDLFAK"
     gene            complement(26356..27054)
                     /locus_tag="KNP36_000274"
     CDS             complement(26356..27054)
                     /locus_tag="KNP36_000274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBF0872171.1"
                     /translation="MKKRFINKSIIIGSIVLGVLVSLQLKIINIENRGMTTFKRGEQL
                     TEELKSLKKEKENLQSEVNSVKKDIETYRGKNNEGEQDILKSEIEKYETLAGYTDVEG
                     TGIKIEINSTKDLGNSDKNDSILYNYDLLLSMINKLNSAQASAISINDQRIVSNTYMY
                     LKEDKLYMNDTVIKEPIIIKAIGDSDTLASALNIKYGIVWEIETYYNAKVKVTKEDNI
                     EINGHSDINKAEGK"
     gene            complement(27077..27817)
                     /locus_tag="KNP36_000275"
     CDS             complement(27077..27817)
                     /locus_tag="KNP36_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsQ-type POTRA domain-containing protein"
                     /protein_id="HBF0872172.1"
                     /translation="MKKRRKLNTNNVMIVLVFILMLSFCICIIVKSDLFDVKKIDVIG
                     NKRVTKSNIMKELNVNLNENIFAYNFKDMKNKLIKNPYIENVEIKRKLPNKIIISLKE
                     KEIFAVLKDEDNYCYIDKKGNLLEELRGSNESKKDLIVDVDYSIDDNKSIKFKNYKTK
                     ENVFKTLNYLKEEGIYRKINYVNLKKESNIEMLTRSNIKILLSNDDNLDYNISRVSKI
                     LIDLQNKNTNGGTINLNYGKLAVYSPEG"
     gene            complement(28087..29313)
                     /gene="murG"
                     /locus_tag="KNP36_000276"
     CDS             complement(28087..29313)
                     /gene="murG"
                     /locus_tag="KNP36_000276"
                     /EC_number="2.4.1.227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="HBF0872173.1"
                     /translation="MKVLLSGGGTGGHVYPAIAIANKIRDEHPDAEIIFVGTEKGIES
                     EIVPKYGFELKTVTVQGFKRKIDFDNVKRVFKLFKGLEQSRKIVKKFKPDIVIGTGGY
                     VSGPVLFNASMGKIPAIIHEQNSFPGVTNKILSKTVTKVLTSFEDSHKRFPEAAEDKL
                     VFTGNPVRKEILLSRKNIARKNLSISDEKRMVLCYGGSGGSRKINDAMRLVIKNMVNE
                     DIAFIFATGKSYYDEFMGSISDINLKPYQKVVPYLEDMANALAASDLVIGSAGAISLA
                     EITALGKPSIIIPKAYTAENHQEYNAKSIEKQGAGIAILEKNLTPESLNTAVFKLLGD
                     RELLVDMANASKTIGKPEAIDLIYDEIMKVYNSTQKSTSKKTKKEKVIKEVKEIKKET
                     TPSIEGQAKVIGIKKR"
     gene            complement(29331..30461)
                     /gene="spoVE"
                     /locus_tag="KNP36_000277"
     CDS             complement(29331..30461)
                     /gene="spoVE"
                     /locus_tag="KNP36_000277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein E"
                     /protein_id="HBF0872174.1"
                     /translation="MPKENLKKQIDIRVKTEFDGVVFYTTMLLVFVGIVMVFSASFIQ
                     SSFKHNDAYYFLKKNVIYAVLGFIVMIITSRIDYSFWKKNATAIGAIAVVLLLLVLTP
                     LGIEANGAKRWLGIGALTFQPAEIAKFATIILTAKLIEKNYDKIKSLTKGVVPLLVVP
                     GIFFALIILQPNLSTAGTVILVTFVMIFVAGMDMKIVFAMIGSGAALFAALVIAEPYR
                     LSRVTSFLDPFQDPLGKGYQVIQGLYALGSGGLFGLGLGKSKQKYFYIPEPQNDFIFA
                     IIGEELGLIGCIIVIMLFVVLVYRCVRIALKTSNVFACMVVIGIGAQIGIQAALNIAV
                     ATSSMPATGVALPFISYGGTSLTIFMGAVGIVLNISKHVKIN"
     gene            complement(30513..31868)
                     /locus_tag="KNP36_000278"
     CDS             complement(30513..31868)
                     /locus_tag="KNP36_000278"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HBF0872175.1"
                     /translation="MDLKGKKVLLVGLAKTGISTIKHLDKLGASIIVNDIKDENKLRN
                     ILDELKSINDIKYILGHHPEDVDDIDMVVVSPGVPLDLPFILKLKNSGKYIIGEVELA
                     FKLSDNPIFIGITGTNGKTTTTSLVGEIFSRAKRDTYVVGNIGNPVIDTIETSSEESV
                     LVTELSSFQLESIDEFRPKVSAILNITEDHLNRHHTMEKYIEAKANIFMNQTVEDFCV
                     LNYDDEIVKSLADKCNAKVIYFSRTKKVNGGVYLENNDIIIDIDDKIKFLNKDDVSLP
                     GGHNLENCMAAIAIAYVCKIDLEVIKDVLMTFKGVEHRQEFVRNLDNVIYVNDSKGTN
                     PDSTIKAIQSYDRPIILIAGGMDKGSNFDELLETAKSYVKSLVLLGETASNIENCAKN
                     KGFNDIHIVKDMEEAVKTSYEISKSGDIVLLSPACASWDMYESFEVRGKDFKDNVNNL
                     K"
     gene            complement(31887..32855)
                     /locus_tag="KNP36_000279"
     CDS             complement(31887..32855)
                     /locus_tag="KNP36_000279"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HBF0872176.1"
                     /translation="MMLGITELTYTALIAFLIVIIIGPIFIPMLRKFKFGQTVRDDGP
                     QTHLAKNGTPTMGGIIMIVAILITGLTRVKVSHDMAVGLICIAGFGFIGFLDDFIKIK
                     LKRSLGLKAYQKIILQVALSFYVAFYQYTSSSSASQLMIPFTDFVINVGILYIPIMMF
                     IIVAIVNAVNLTDGLDGLASGVTLIVSVFFMLFASSIAGNTEVAVLAAATVGACLGFL
                     GFNSYPARVFMGDTGSMALGGAVVAFSVLTNSVLIIPIIGGIYFAEALSVLIQVGYFK
                     ATRKRFFKMAPIHHHFEQCGWPETRVVFIFWIITVVLAWISIIAVF"
     gene            complement(32896..34269)
                     /locus_tag="KNP36_000280"
     CDS             complement(32896..34269)
                     /locus_tag="KNP36_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HBF0872177.1"
                     /translation="MECLTIKELVLATNGKLIYGDYNDCVSDIVIDSREANAQNAFVA
                     IVGENLDGHTFMKSAYDSGCKTFIKNESNGIKLESSDINLIEVKDTSLALGDISKYYK
                     EKFDIPFIGVTGSVGKTTTRDMIYSAISAKLNILKNEKNLNNHFGVPLTLFNLNKEHE
                     CAVIEMGMSGFNEIKYLVDIVNPKIAVISNIGLSHVEKLGSQEGILKAKMEITSNFDE
                     TNTLIVNGDDKFLSTLKEKEHVYKLKTFGFNKNNDVYCESYTMEEDSLTFICVIDGKK
                     EEIFIPTIGEHNIYNAMSAILVGLCLNISLDYIKKGLKNFKGTKMRLDIIKNEKLTII
                     NDSYNASPDSMDAALKILGRYKGRRVAILGDILEMGEISEYGHRLVGKSSMNNTDIII
                     TIGENSVFIGEEAKQLGFNSANIYHFENREDVFNKLNELVKTGDTILVKGSRGMRLEK
                     IVEYLNK"
     gene            complement(34436..36415)
                     /locus_tag="KNP36_000281"
     CDS             complement(34436..36415)
                     /locus_tag="KNP36_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein D"
                     /protein_id="HBF0872178.1"
                     /translation="MRKVKRISKKRLVLVLILACALFFCLVIRTGYLQLMKGNWLSTK
                     ALEQQTRDIPIEPKRGTIYDRNMKELAVSVTKYTVWCKPVEVEDKKEAAEKVAEILDE
                     DYKDIYALISKKNMALVKVKRWIDDDKASQIRDAKLSGIWVAEDNQRYYPYGNFAPYV
                     LGHTSSDATGISGVEMQYDKKLKGKPGKLIVSTDASGREIPQGMEKYYEPVQGNGLVL
                     SIDEVIQHYTEKAVQKAYELNNAKKVTAIAMNPKTGDILALASKPDYDPNDSRTPIYP
                     YYQEELEKYNDKDKIKGYYQMWRNPAVSDTYEPGSTFKLITSSSALEEGVIKDGEKFT
                     CTGSVTVGGRKIKCWRHYRPHGTQEFKQAVQNSCNPVFVELGSRLGVGKMYDYIESFG
                     LMDKTGIDLPGEAKGILYNEKNVGPVELATISFGQSISVTPIQLITAISSIANGGDLM
                     QPRVVKSYTDNKGNITETVKPKKVRSVISKETSKKMLEIAESVVTEGGGKIAYIPGYR
                     LGGKTGTAQKVIDGKYAPGKYICSFVGIAPCDDPQIVVLAIVDEPTGVSAFGSTTAGP
                     IVKEIMNDSLKYLGVKPVYKEEEKAEYEKKQVKVPDVRNLKIGDAVKALEDAKLKPDL
                     DADIELPEDTKVKDIFPKPGVKVNEDSSITLYFEN"
     gene            complement(36427..36774)
                     /locus_tag="KNP36_000282"
     CDS             complement(36427..36774)
                     /locus_tag="KNP36_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872179.1"
                     /translation="MKKNYKIHNLNEYKNKKKNNYKKRNKKKIGAKCILLIATFSVII
                     LNLCGYSKISEMKYDIYYLQKDLRKKEIVLEELKAKETEKTSIKEIELKAKELLNMDY
                     PKDGQIKYIDVDN"
     gene            complement(37255..38190)
                     /gene="rsmH"
                     /locus_tag="KNP36_000283"
     CDS             complement(37255..38190)
                     /gene="rsmH"
                     /locus_tag="KNP36_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HBF0872180.1"
                     /translation="MEFHHVSVLLNECIENLNIKPDGVYVDCTMGGAGHSKEIVKKLS
                     DKGLFIGFDQDKNAISTAKERLSEYESRVKFVHSNFENIKEELEKIGVYKIDGVLADL
                     GVSSHQLDEADRGFSYMQDAPLDMRMDVRCEFSAYDVVNTYTEDELTKIIKDYGEDNW
                     AKRIAKFIVEERANKPIETTGELVDVIKKAIPKKARIDGPHPAKRTFQAIRIEVNNEL
                     GVITKMINDASSIMNEGGRICIITFHSLEDRIVKNAFKHLASDCICPQHLPICQCDKE
                     SEVKIITRKPILPSEEEIEVNPRSRSAKLRVAEKI"
     gene            complement(38220..38966)
                     /locus_tag="KNP36_000284"
     CDS             complement(38220..38966)
                     /locus_tag="KNP36_000284"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HBF0872181.1"
                     /translation="MDRVAFTLFGIDIMWYGILMACGMILGTLIAIKEAKRVGIKEDD
                     VLNIAIIAIPVGLICARIYYVVFNWSYYAQNMSQIFNFRGGGLAIHGGLIGGILAGYI
                     YTKIKNINFLKMADTVILGMPLAQAIGRWGNFINGEAHGGATNLPWGIMVDGVKVHPT
                     FLYESIWDFGIFIVLLLFRKNKKYEGQVIVTYITLYSIGRFFIEGLRTDSLMLGPLRM
                     AQVISLIGVIGGIIAHVYLSKKNKNNISEE"
     gene            complement(39360..40646)
                     /locus_tag="KNP36_000285"
     CDS             complement(39360..40646)
                     /locus_tag="KNP36_000285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBF0872182.1"
                     /translation="MEKIVNDILKEEVYYEKLQNGLDVYFMPKRGFMKKYAILATNYG
                     SNDLEFVPIGEDKKIRVNEGIAHFLEHKMFEQPDGGDAFDKFSKLGVNANAFTNFTMT
                     AYLFSATENFYESLEHLIDYVQTPYFTDENVEKEKGIIAQEIKMYNDDPDWNVYFNCL
                     KAMYVNYPARIDIAGTVDSIYKITKEELYKCYNTFYNPGNMALFVVGDLDVEKVIDVT
                     KKSNNYKVDRLSKSIERFYPEEPESVKEKEVIEKFPISMPMFNIGFKDSNVGLKGKEL
                     LRKEIVTDILVGMLFKKGSKLYEDLYMQGLINENFGAGFSSQVDYAFSIIAGDSKEPK
                     KVKEIILDYIEKSKKEGLSKEEFERTKKKKIGSFIKCFDSINFIGNSFISYVFKDINL
                     LDYLDIIKDITFEEVEERLKEHFKEEYCVISIVEPK"
     gene            complement(40661..41926)
                     /locus_tag="KNP36_000286"
     CDS             complement(40661..41926)
                     /locus_tag="KNP36_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBF0872183.1"
                     /translation="MVNTKKIINLGNNINLTLIKTEKFKSNLISLYVQRLLDEKETTK
                     NALIPSIIASGSAKYPSARAISNKLDDLYGSSMGADAVKRGERQVLSFKVINISEKYL
                     DESIFEEVVEFFNEVINNTLVVDGGFKEEYLNIEKENLREKIQSIINDKKEYAQDKCI
                     EAMCKGERYSVSEFGYEDEIDSITSRELYEHYKNILKTSPIDIVVEGNFDEDKVVDII
                     SKNLKFEREEIINIPRADFIKNVDEVKVIDEQMEITQGKLVMGYRANVDYADIDKYYA
                     LVVGSNVLGGGPHSKLFVNVREKESLCYYIFSSIEKYKSIMFISSGIETKDYDKAVEL
                     IKKQVESVKAGDISDEELENSKLALVNSMKSITDNIGGMSDFVFSQSMAKTNSEVQDI
                     ISSIEKVTKKDIVEAIKNIELDTVYFLRN"
     gene            42242..43339
                     /gene="ychF"
                     /locus_tag="KNP36_000287"
     CDS             42242..43339
                     /gene="ychF"
                     /locus_tag="KNP36_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HBF0872184.1"
                     /translation="MKLGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGVVSV
                     PDERLNKLQELYNSEKIVPTAIEFCDIAGLVRGASKGEGLGNKFLSHIREVDAIVHVV
                     RCFEDENVVHVDGSVDPLRDIETINLELIFSDIEILERRINKTQKAAKADKTLGSELD
                     LLKSIMSTLEESKCVRTMEFTEDEQTFVNSLDLLTSKPVIYASNVSEDDLADNGENNK
                     YVQQVKAFAETEDAEVVVVCAQIEAEISELDSAEEKKEFLETLGLEQSGLDKLIKSSY
                     ALLGLISFLTAGPKEVRAWTIKVGSKAPQAGGKIHSDIERGFIRAETIAFNDLVEHGT
                     MAAAKEKGLVKLEGKEYIVKDGDVILFRFNV"
     gene            complement(43818..46097)
                     /locus_tag="KNP36_000288"
     CDS             complement(43818..46097)
                     /locus_tag="KNP36_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0872185.1"
                     /translation="MLSDAKNNRYGLSIIAVISILVITISCLIYGSRLNKTLGEETNQ
                     YLSEIANQSVNVLKKQINGDIKLLESISIFIEGEESFEVDNILSILKRQAINSSFKRM
                     GVILPNGTAYTTDGYIEDFSKRDYFLKSMQGEVVITGKLKDVIEDDKNTNSNINVYSV
                     PIYKDNEVKGVIFATHSTKLYEKILSVPTFNGKGYSYITRSNGDIVLNPSSKNANSTK
                     ENLFSYIGRSDSISKSSINNMKSNIKNFKSGSLSYSMFGKGYYLSYAPIGINDWYLFS
                     EVPKTAISEKSYAIIKLTLSACVVLIIIFTALTIYILFIHKKSKEKLEEFAFKDNVTG
                     IGNSNKFNLEGGKFLSSHEKKNLVLIYFDIDKFKLVNDRFGYEEGDRVLKEIAEIIKN
                     IFKEQSVFSRISNDNFAIIFEKKNNRESIIEICELIRKKLSMIKTSLGVELNLIPSIG
                     VYFVEEGETNISTCLDKAMIAKTTVKRKYLKVYEIYAENLKETLIEERDIEQEMHDAL
                     KNEQFKVYLQPKVDLSTTKIVGAEALVRWQHPKKGLISPGVFIPIFEKNGFITELDMF
                     VFTQVCKNFKRWENENFPTFPISINLSRVHLENPGFISELERITKEYEIEPNLIEIEL
                     TESAIFDNTKILFKIMQTLKSVGFKISMDDFGSGYSSLNMLKDMPIDVLKLDRQFFIT
                     VGNAKKSQIVVSSIVQMAKQLDIKVVSEGVETVEQAEFLRFIGCDMAQGFLFARPMPI
                     EEYEKLILDRYSLNRKETN"
     gene            complement(46368..47822)
                     /locus_tag="KNP36_000289"
     CDS             complement(46368..47822)
                     /locus_tag="KNP36_000289"
                     /EC_number="6.3.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="HBF0872186.1"
                     /translation="MKLNDIIQGLDIINVKGELNIDINNVQYDSRKVTKGTLFICIKG
                     FVSDGHKYIKDAIEKGASAFLVEEDVAIKGCTFIKVKDTRKDMAKVADNFYNHPSQKF
                     NVIGVTGTNGKTSITTILNEILTLNKNKVGLIGTIKIFDGEKDIVSNSTTPESIDLQY
                     HFNNMLDNGCDYCAMEVSSHSLALNRVDETDFKLGIFTNLTPDHLDFHKDLEDYRKAK
                     EKLFFKTTMANIINIDDEGGKKIYENIKGINVPCYTYGVDTKADFMARDIKSDSDGVS
                     YRLITPSYEEVIFIPVPGMFTVYNTLAVIAACYVLGIPKPIYKEGLRLSNGVSGRFET
                     VPNDKGISVIVDYAHTPDALENVLKTTQQFAEGKIISVFGCGGDRDTEKRPLMGAIGQ
                     KYSDLCIITSDNPRTEEPEAIIKDILEGIDKKKENYHVVVDREQAIAEAISMAKKDDV
                     VIITGKGHETYQIIGKVKHHFDDKEVANECLSKM"
     gene            47986..48855
                     /locus_tag="KNP36_000290"
     CDS             47986..48855
                     /locus_tag="KNP36_000290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872187.1"
                     /translation="MDNKIGYLNDNFKIFNIRDKKDIQFEYHNHDFNKIIIFINGNVT
                     YFVDGIPYKLKPWDILFISNNEIHKPVIDSNVFYERIAIWISPEFMKKNSDASSDLEK
                     CFKIATENKCNRLRLNMHDIESIKSFIEQINISESNTEFGNEILRNTLFIQLMIFLNR
                     IFLKNENMESTEDVFYDETIKKVLNYINSNIDDKLSIDSISSEFFISKYYLMRKFKSH
                     TGTSIHNYIVQKRLILAKSLITNGHLMSEVCNKCGFNDYSSFVRAFKKNYGVSPKNYI
                     NNKNPLDITLLDE"
     gene            complement(49068..51140)
                     /locus_tag="KNP36_000291"
     CDS             complement(49068..51140)
                     /locus_tag="KNP36_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0872188.1"
                     /translation="MKKVFGVLQKVGKSLMLPVALLPAAGILLGVSNALAGDALLAHF
                     PALANPTFQLIISIMESSGQIIFNNLPLIFAVGVAVGLTEGEGVAALAAIVGFLILNT
                     SMGVMAGVTEDMVDNSMYANIVGIPTIQTGVFGGIIIGIVAAYLYKKFYKIELPQYLG
                     FFAGKRFVPIVTSLVAIAIGIILSFIWPPIQEGLLSFSKNVIEANQTLAAFMEGSLER
                     LLIPFGLHHVFHNPFWYQFGEYVNKAGELVMGDQKIFFAQLKDGVNFTAGTFMTGAFP
                     FMMFGLPAAALAMVHEAKPEKKKFVAGIMASAALTSFLTGITEPIEFAFLFVAPVLFA
                     IHCLFSGLSYAIMQLLGVKIGFTFSGGLIDFLLFGVLPNRTPWYLAILVGIGFAVLYY
                     SVFRFMIRKFNLKTPGREDESETNAEVIEMSKNELASEILIALGNKDNLKSLDACITR
                     LRLVVNDINKVDKEKLKSLGAAGVMVIGNNVQAIFGPKSDSIKSDIKDIIEGKTKVES
                     TVTKNVDKNKVKKNMEVANMENTLVEKIDSLTNGELLDIEEVPDSVFSSKLMGDGFAI
                     KSSDGLIYSPVDGTIGVIFPTKHAIIIKSQKSGVEILIHLGIETVNLEGNGFEVFVNV
                     GDEVKAGEKLVKMDLEYIEKNGLSTISPVVFTNLEQNQKLSIKKGVTTAKEENRVSIL
                     RDDIEKIG"
     gene            complement(51443..52285)
                     /locus_tag="KNP36_000292"
     CDS             complement(51443..52285)
                     /locus_tag="KNP36_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0872189.1"
                     /translation="MIIQQIYNNNVVLVLDENIKKELILTGCGIGFQKKKGQEIDKSK
                     IERTFVIQDESFLDKISKLASQVDEKFFEVSTEIIAYAEENLNTKLYEYIYVALTDHI
                     AFAIKRYHENITIKNDLLHEIKRIHKKEYEIGKWAVDYINKEFDVKFPVDEAGFIAMH
                     IVNSNYKGSSKESLLITKIVKDILNIIRYYYRVEFKEDDINYDRLLTHLKFFAKRLVK
                     KEKINDTNNEIIDIIKVKYEKDYDCAYKIKTHVEKNYDYYVSQDELLYLTLHIKRVIS
                     VLNL"
     gene            complement(52546..54588)
                     /locus_tag="KNP36_000293"
     CDS             complement(52546..54588)
                     /locus_tag="KNP36_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:proton antiporter"
                     /protein_id="HBF0872190.1"
                     /translation="MSILVTLLGLLVCTTISTVFSKKWSNIPLAIYQIVLGIILSILP
                     FKFSFSFNPEIFVICIIAPLLFSEGQNVSRKELLELRKPILLLAFGLVLITVFAGGIF
                     IHFLIPGMPLSVSFALAAVISPTDLVAVKSITQGLNFPKNMMSILEGESLLNDAAGVV
                     AFKVAVLATVTGVFSIEEAGIQFMITAFGGIIVGSILGYIIIKIRLSLHKWNLEEIPM
                     VIVIQIMTPLFVYFVAEEIGVSGILAVVMAGIAHGIEKEHLQNTTTKLRIISDNTWYV
                     LEYVLNGFVFTLLGFLLPSIYTGLSSKNENMALELTFISTLIVLILFVIRFIWVYLWH
                     NSFIKPKKNPLNNFFVGFLGFKDEEVVKESISKCKYSLIVATCGVHGTFTLATALSIP
                     FYLADKDVFPMRDTVLFISSEVILISLVLATVLLPRLLKNNVQESEPLLSDKEAYKLI
                     LKEAILKLSNEKAQEVQPVIHDLNEQLVDSEKGILNTPDNKLISMMIAEADQQGLLAV
                     LKLLEDGKISDRAFKLYRFYITKSRKSVQKSIFKIVKLKISMWIINRKVKKEVKEKIT
                     KIVSENKEIIKEFHHAYALSTKTAISFINKNTDEDNRHEALIAIRFYNRYLNWITRKI
                     QNDDKFEARVEYYRVMAIQSQRDSVQQLVETKQISREVAKELLENILYDEMMMIES"
     gene            complement(54740..55711)
                     /locus_tag="KNP36_000294"
     CDS             complement(54740..55711)
                     /locus_tag="KNP36_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="HBF0872191.1"
                     /translation="MKKEESLLKVEGLKKYFEVKSGLFDKEIKCVKAVDGISFDLKKG
                     ETLAIVGESGCGKSTAGRTILRLIEKTEGKVEFNGVDIYKLEKEELRKLRPKMQMIFQ
                     DPYSSLNPRLNVEQIISEAVIEHNLVPKNEIKDNILNVVESCGLSKYHLNRKPGEFSG
                     GQRQRIGIARALALNPEFIVCDEPVSALDVSIQSQIINLLMDLQDKYKLSYLFISHDL
                     SVVNHIAHRVCVMYLGSIIEIATKGELYLHSQHPYTKALMSAVPIQDPTIKKNRIILK
                     GDIPSPTNPPSGCKFHTRCPYCKEICKKEIPVLKEISRNHFVACHLV"
     gene            complement(55712..56689)
                     /locus_tag="KNP36_000295"
     CDS             complement(55712..56689)
                     /locus_tag="KNP36_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872192.1"
                     /translation="MSKALIEVKDLKVYFHTDKGIVKSVNEVSFNINEGETIGIVGES
                     GCGKSVTAMSLMKLLPTSKIEGGEIIFRGKDILKMNEDELMGIRGNEISMIFQEPMTS
                     LNPAFTIGSQIIEGIMIHQDLSKEEAKKKVIDMIKLVEIPRAEEIYNSYPHELSGGMR
                     QRIMIAMALSCNPKLLIADEPTTALDVTIQAQILDIMKNIKEKLNTSIMMITHDLGVV
                     AEMCDKVLVMYAGKIIEVAEVVELFKNPKHPYTIGLLKSKPALGKNKDKRLYSIPGQV
                     PNPIGMPDSCYFSDRCEKVCDKCRTQIPPLIELNSGHSIACWLYKKEEI"
     gene            56908..58467
                     /locus_tag="KNP36_000296"
     CDS             56908..58467
                     /locus_tag="KNP36_000296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0872193.1"
                     /translation="MKFKKLASLILVSSLMLTFTACASNDKDKSSGSKSGGTVVIPMA
                     SDPDIINGAFANVKEDSLASNIVYAPLYTYEKGNLVNYLAEKVDFKDSKELTIKLKSN
                     LKWHDGKPITAEDVLFTFNTVLDEKQNSPSRQYLLVGEKPVKVEKIDDLTVKITLPTA
                     SESFLYGISKISPIPKHVFEGESNIAKSEKNNNPVGSGAFKFKEWKKGESIVFEKNAD
                     YFGGESKADSIALKIIPNEASQEAALNNGEISLMKTSAEGYEKAKSNSNLQTYTYSEE
                     RLNYIVFNQNISNMANKEVRQALSYALNRNEMIESAYGKEGSVPAKSILVPEADFYTE
                     EGVEGYDQDTNKAKDLLDKSGVKIDKLKIGYNTGRFGHKNYALVAQQELKKIGIEAEI
                     VPYESKAFFNILFSNSTECDMYVNGYAWGLEPNPYRGMFETGQYCNQTKYSNAEIDAL
                     WEKGFTELNKEKREEIYKQIQQDISKDAPIYTIDYEQNLMAAQKNLKGIKDAKPSPAI
                     LFEDWSKLYVE"
     gene            58573..59532
                     /locus_tag="KNP36_000297"
     CDS             58573..59532
                     /locus_tag="KNP36_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872194.1"
                     /translation="MLKLILNRVKVLIPMLILISILSFGLLELAPGDPADAYINPLMS
                     SQDIENIRVNMGLDKPAYIRYLNWLKNTLSGNLGISYINHMPVTEQIMEKMGNTFILM
                     GTSLIFSILVAIPLGIFLAVNKNSITSKVSSVFNYIGVSIPSFWIGMILISIFSVKLN
                     IFPSGGMHTIGNDSIGDLAKHLVLPVITLGLYNTAIFTNYVEASVNEQLKKQYVITAR
                     AKGLSEKVILFKHVLKNSLTSLVTILGMSIQKLVTGAFVTEVVFSWPGMGRLMIDSIF
                     SRDYTVIMAITMLSALFLILGNLVADILYLLIDPKIKSSKGGF"
     gene            59535..60347
                     /locus_tag="KNP36_000298"
     CDS             59535..60347
                     /locus_tag="KNP36_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872195.1"
                     /translation="MFTSILKKLKKDKSFAFACITLSIIIILIIASFILNIDSNAIDT
                     TSKLQEPSLKHIFGTDELGRDYFSRALYGGRISLSVGILSMLISVVFGTAVGVISGYI
                     GGKLDQFLMRLVDMLMSIPSFLVLIVLNTYLTPKVSTIILIIGFLSWMEVSRIVRGET
                     LKIKENEYCLAAKATGIKTRNILLRHIVLNLKETIVVAGSLNIANAILTESALSFLGL
                     GIQLPLASWGNMLQDAQRHIFDKLYLAVFPGLLIFLTVMSLTIISKKFSSNT"
     gene            complement(60563..61465)
                     /locus_tag="KNP36_000299"
     CDS             complement(60563..61465)
                     /locus_tag="KNP36_000299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0872196.1"
                     /translation="MDIKQLKYFVEIVKSGFNLSIASKTLHISQPALSQIIKNFEESE
                     DVYLFERYKGRLNGLTPAGERFYVNAEHIINEYKNMMEDLREDSVQFKGKVRIGIPPL
                     ILGIAFSDVVAQLVANNPDIEFDIVEKGAYDLNRMLILQELDYAVLLHPHKIDKSVVT
                     EHVLQEDELTAFLNINHPLAKKDKIDWNDLNEQLLAIFNPTFMIHHKLMQKFTDENVK
                     LKRYIMSGSWDFLLLSTTNSDFITILPSPVHDFFENSKIIEKPFNHPITWKVILCRPK
                     KERYSHVDQHVFKFIIDFFSKKNS"
     gene            61820..62998
                     /locus_tag="KNP36_000300"
     CDS             61820..62998
                     /locus_tag="KNP36_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HBF0872197.1"
                     /translation="MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVRLN
                     LSEIDEVIIGNVLQTGLGQNVARQIAINAGIPNSVPSYTVNKLCGSGLKSVQLAAQSI
                     TSGENDVVIAGGTENMSQAPYIVPTARFGSKMGDITMVDSMLTDGLIDAFNQYHMGIT
                     AENIATKFEFTREMQDKLALESQNKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDE
                     YPKLGMTFEGLSKLKPAFKKDGTVTAGNASGINDGAAMLILMSQQKADELGIRPLAKI
                     KSYASAGVEPEVMGTGPIPATRKALKKAGLSINDIDLIEANEAFAAQALAVKNELQID
                     SSKLNVNGGAIALGHPIGASGARILVTLIYEMQKRKVETGLATLCIGGGQGISMVVSR
                     "
     gene            63007..63663
                     /locus_tag="KNP36_000301"
     CDS             63007..63663
                     /locus_tag="KNP36_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase subunit A"
                     /protein_id="HBF0872198.1"
                     /translation="MNKIVSIDEALSHVKDGDTIMVGGFMANGSPENLIDYLCSKNIK
                     DLTLICNDTGFIDKGVGKMVVNKQFKKIIASHVGLNKETGRQMNNNETDVELVPQGTL
                     AEQIRAAGYGLGGILTPTGIGTLVEEGKQKIVVDSKEYLLEKPIYADVALLFASKVDK
                     AGNLVYKGSMNNFNNLMASAAKITIVEADEIVEIGDIDPNEVNTPGIFVNYIVEGGNL
                     "
     gene            63663..64328
                     /locus_tag="KNP36_000302"
     CDS             63663..64328
                     /locus_tag="KNP36_000302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="HBF0872199.1"
                     /translation="MDKLEMQEYIANRVSKELKDGAVVNLGIGLPTKVANYIPDNVNV
                     ILQSENGFLGLGSAEDGNSSDETIVNAGGQPVTILPGGCFFDSATSFGIIRGGHVDIT
                     VLGALQVDKYGNIANYMIPGKMVPGMGGAMDLVTGAKKVIVAMEHTSKGSAKILNNCT
                     LPLTATNAVDLIVTEMGVMEVTSDGILLKEINPAFTLDDVISATEAPLILSDSLNGKI
                     SVV"
     gene            64433..65209
                     /locus_tag="KNP36_000303"
     CDS             64433..65209
                     /locus_tag="KNP36_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="HBF0872200.1"
                     /translation="MVKDKVVFVTGAASGIGKQIAESFLKNGAKVMFSDINQEALNNT
                     ITELQKKGYDCMSVKCDVTKEEEINHAIDKTVEKYGRLDILINNAGLQHVSMIEDFPT
                     DKFEFMIKIMLTAPFIATKKAFPIMKKQGFGRIINMASINGVIGFAGKAAYNSAKHGL
                     IGLTKVAALEAADSGITVNALCPGYVDTPLVRGQFNDLSKTRNIPLENVLEEVLYPLV
                     PQKRLLDVQEIADYAMFLASDNAKGITGQACLLDGGYTAQ"
     gene            65271..66605
                     /locus_tag="KNP36_000304"
     CDS             65271..66605
                     /locus_tag="KNP36_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBF0872201.1"
                     /translation="MSIIAPIGIIIGIIAIIYFSVKEIHITIAAPIATLIVVILNKMD
                     VVTSMLGADKNNYMGALGNYIMSYFAIFLLGSILAKFMEESGATVSIADFILNKFGSN
                     HPYRVLVAIFIVSFILTYGGISLFVVMFAVIPLARTLFKKLDISWNLIQIPLWLGIAT
                     ITMTIIPGTPAIQNVIPIQYLNTSLTAATIPSIVGSIGCATFGLVYMKYALNKSIRKG
                     ETYATYTSELEEESLDRELPGFFASIFPLLALVIIAITGSTFGSEFMKKNVIYIALIV
                     AILLSAFLFHKFLSSKIQTLSIGASGSIGPIFATSSAVAFGAVIMAAPGFDVFSKLIM
                     SIPGSPLISLTVLTSTMSAITGSSSGALGIVMPNFADYYLSTGLNPELIHRVATIASN
                     ILTIVPQSGVFLTFLSLSKLTHKTGFKETFIVVAVGSLIAEIIVITLGLLMY"
     gene            67101..68033
                     /locus_tag="KNP36_000305"
     CDS             67101..68033
                     /locus_tag="KNP36_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein"
                     /protein_id="HBF0872202.1"
                     /translation="MMRRNIPTKLKTILALGVLTLATASSAVTASASSLENNVNISNK
                     SLVYSNTKYKFSAKPNCSVKPELKPDKDNSCKDKNHNDKNCNNTNKPEDNNNSDSTNK
                     PDNNKPESNKPEDNNNSGSTNKPNNNKPESNKPEDNNNSGSTDKPDNNKPESNKPEDN
                     NNNNSDSTNKPDDNNNSGSTSESFSAYQKEVVDLVNIERAKAGLNPLTLDSSISNVAT
                     KKSQDMIDNNYFSHNSPTYGSPFDMLKKFGISYKTAGENIAMGQKTPKEVVNAWMNSE
                     GHRKNIMNPNFSKIGVGVAQKSGGSIYWTQIFVG"
     gene            complement(68425..71964)
                     /gene="nifJ"
                     /locus_tag="KNP36_000306"
     CDS             complement(68425..71964)
                     /gene="nifJ"
                     /locus_tag="KNP36_000306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate:ferredoxin (flavodoxin) oxidoreductase"
                     /protein_id="HBF0872203.1"
                     /translation="MAKFMKTLDGNTAAAHVAYAFTDVAAIYPITPSSTMAEVVDEWA
                     SQGRKNIFGQTVNVVEMQSEAGASGTFHGSLQGGALTSTFTASQGLLLMIPNMYKVAG
                     ELLPGVFHVSARALASQALSIFGDHQDVMAARQTGCVLLASGSVQEVADIAPVAHLAA
                     IEGRLPFIHFFDGFRTSHEIQKVELLENEDYASLLNFEAVQAFRDNALSPNHPVARGT
                     AQNPDIYFQTREASNKYYQNIVGIVEKYMEKMSNLTGRKHSLFDYYGAEDAKYVLIAM
                     GSVTETIEETIDYLNAKGEKYGLVKVHLYRPFSMKHFLDAMPSTVERICVLDRTKEPG
                     STGEPLYLDVRDVFYGKENAPMIIGGRYGLGSKDTTPSDIKTVFDNLVSEQPKNGFTV
                     GIVDDVTNTSLTPSEPIKIASKGTIRCKFWGLGSDGTVGANKQAIKIIGDHTEKYAQA
                     YFDYDSKKSGGITMSHLRFGDTPIRATYLIDEADYIACHKQSYVYQYDLLKGLKKGGT
                     FVLNTIWDQAGLEEHLPAHMKQYIAKNDIKFYTVNAVKLGQEIGLGNRINMIMQSAFF
                     KLAEIIPEEDAVKYLKDSIVKAYGKKGEKIVNMNYAAVDAGINALVKVEVPASWENAV
                     DADKGEVKEPEFIKNILRPMTAQEGNNLPVSTFNGIEDGTFPCGTAAYEKRGIAVDVP
                     EWIIDNCIQCNQCSFICPHSCIRPVLVTEEELANAPEGFEAKKALGKGLEGLKYRMQL
                     SPLDCTGCGNCADICPAKEKALVMKPIDTQLDTELDNWAFAVNPDEVAPKGDVMPVNT
                     VKGSQFRQPLMEFSGACAGCGETAYIKVVTQLYGDRMMIANATGCSSIWGASAPSIPY
                     TCNHEGKGPSWANSLFEDNAEYGFGMYTAVKQIRNKIVDAMTELVSMGICEDAKAVFT
                     EWLDSRNDGEASKVASAKVVELLEKPACDCTDEKAKELVKAIKDRKDYLVKRSQWILG
                     GDGWAYDIGYGGLDHVLASGEDVNVLVFDTEVYSNTGGQASKATPAAAMAKFAASGKK
                     SRKKDLGMMAMTYGNVYVAQVAMGADKNQFIKAVIEAEKHDGPSLIIAYAPCINHGLK
                     EGMGRTVANEAQAVACGYWHLYRFNPEVKAEGKNPFTLDSKEPTASFKDFILAQVRYS
                     AIAKQFPEEADGLFAKAEADAKERYEGYKKLAE"
     gene            complement(72482..73051)
                     /locus_tag="KNP36_000307"
     CDS             complement(72482..73051)
                     /locus_tag="KNP36_000307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate propanoyltransferase"
                     /protein_id="HBF0872204.1"
                     /translation="MKLPIALSNKHVHLSQADIDVLFGAGHELTKFKPLSQPGQYACE
                     EKVDLVGPKGTLKGVRVLGPARAHTQVEISLADGFPLGVKAPIKESGDIAGTPGVKLV
                     GPAGEVEMKEGVIVASRHIHMSNEDAAKFGVTDKQIVKVKTSGPRALVFENVLVRASD
                     SFNLEMHVDMEEGNAAGVKNGDLVELIVD"
     gene            complement(73123..73731)
                     /locus_tag="KNP36_000308"
     CDS             complement(73123..73731)
                     /locus_tag="KNP36_000308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0872205.1"
                     /translation="MDSNDKKGLKSPEIIIINGSPRINKNCSFIANEVKAMLEECGLS
                     CKIFNIYNMDIEYCTACGFCEKTGYCKFNDDMKPLYKMFDDSKGTIVISPVHFDSISA
                     KLKTVVDRTQAIYASKYVLNKPSIDRSKKRIGMYIAVGGSKSYDSQFKGGQIVMDFFF
                     KSINTKLLHNIYLNNTDDVSYIDNQEFKDIIYKNLKIYIDSI"
     gene            complement(73739..75502)
                     /locus_tag="KNP36_000309"
     CDS             complement(73739..75502)
                     /locus_tag="KNP36_000309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="HBF0872206.1"
                     /translation="MTNGSYKMKNLVEISAMVTESTDFFNIKDDIIEKMLEVVHPTKA
                     CVNLFYKNDSKYAYLVCSQTLEYVPQIFPINSLKGAKIDFDTYPEYIHEAVNEKKIIY
                     VENVFEDSRAEGERDLAKAEGYIGRIVFPFIINNVVVGFMTCFLKEDDYITEQDIDFI
                     SSVASLLSLSIEITNKNNNVQILIDKLRGSISAINEATKKLYLNKSIDGFLENLSKQA
                     CNITNSKEALIIINSHHNKDAIVSCYNVEQKKKTNLYPMIDMFLKKESLGGYLNNLKP
                     CSKKGINLESYIYYKLQDKNDTIGCIVCANSKNYTSDDLNILSILSKQVSVGMQLYEH
                     NEKEVKHKVLENELNILNKQQQLIMDKGKMDCNDEKELYFYHKPARVVGGDFYYATKV
                     DDEHIVYIVADVMGHGMVSNYVVAMIKGAFKVLCNQYNTPREIMTNLNRMLYDEFDKM
                     GVFTTCLIGIIDTKENMITVSNAGHYSPVVVKKDGTIENNLNCKKGIPIGIMEDATYE
                     NNTLSMEDYAMVCMYTDGILEIKNSSKEEYGINRLENFLKENFRLNQQLIVENLKLDL
                     KNFSSKDNYDDDILIVMLKDR"
     gene            complement(75545..76012)
                     /locus_tag="KNP36_000310"
     CDS             complement(75545..76012)
                     /locus_tag="KNP36_000310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872207.1"
                     /translation="MKMLNGIIKLFYSEIVKTKINNLDSSGYSLRDECKEIRNITLKI
                     DSVFFKLLKLAFGSILLMVAFNLNMVLGIGVFLVGVVYILYKRNMEEQVKEHINNVKN
                     NIDISKITFMDEKGRTGLNALITLLLIGLLTGFNWILVASFVVVFVFTIKNVC"
BASE COUNT        24733 a        13227 c         8647 g        29435 t
ORIGIN      
        1 tcaatattct attattttta tactatttag aaaattcata tattatatat gttttctcaa
       61 caataaatac agttttcata ataatgaaag gtattactta gcaatcgcat gattttctaa
      121 ataatacctt tctaaaaatt atttttttaa ttttatgaat ttaattatac tttttctagt
      181 atcaggattt acaattaata tagaaccaat cataattggt gttagtatac aaaataaaaa
      241 aataatatct ttttttagat tatattcttt agattctaat ttataattat tatttattat
      301 tccatcataa tcacttatat ttgacttatt tttatttgta tcttgatttt tgttagaaat
      361 actttcccta taaggaaaag aatgttcatt ggtaccaaat actaattttg agcttaaatc
      421 ataattatca tcattttctg taattgaatt tttattgtaa aatccttttt ctttatcaga
      481 attattttct ttattaccgt ctttaggtat atcatgagga tttttatttt cattgctatc
      541 agtacttgat tctacatcat ctttaggagt atttggttgt ttctcatcag aattatcatt
      601 ttcattatta ttattttcat tattattgtt ttgattgtta ttactatcat tattttcatt
      661 tccattattc ccatcttgat tgttatcatc ctcatctcta tccgggtcgt ctctacctcc
      721 tcctccacgg tcaccatcaa tatcatcatt ttcccgttca tcatctggtg tctcttggtt
      781 gtctccgcct cccattataa atcctggttt aaaaactata tttgaatacc cttcttttaa
      841 tcctcctacc acttttactc taaaacaacg caacttaaaa tcttcaaaaa aaagtatagc
      901 ttgatctcta atatcctcct gttcttcaga tatccaattg attccatcgc ttgaatattc
      961 aacaaaaacc ttacttgcac tatacggcat atcataaaat aaaacagcta catatccatt
     1021 ttttgtattt tgaaattcca gttccaaatt gtctattggt tttttctcta taacagatac
     1081 attcaaaata ggaactacat catcatttat tataattttt tctttattta acatttctgt
     1141 tttaaacttt cctgttatat taaaattttc tcccttttcc aacttttcat aataatcagt
     1201 aaaatcccat tctacatcta tatcaagtcg attaccacta gatgtttcta ataccatata
     1261 tttgggaaat tttatatttt ctattttatc atctttactt acttttattt catcactaaa
     1321 tacaccaatt cccctatgac aacatttcac aatatcatag ccagaatctt cagctataga
     1381 gggtataagc tcattataat catcaattat ataaactttc ttactttctg atataattga
     1441 ttgtgccaac ttattattat cttttagtaa cccactttca ttgttgctac tatatgcttt
     1501 tattgaagtt tcttctatct caacatcacc tttagaataa acacctatag catgttctcc
     1561 attcacttca atatccttat ttagtattct aatatcattt tcagtataaa ttcctattgc
     1621 atctttccca tttgccttta ttttttcaac agattcgtag gatgatttaa tatgtaagtc
     1681 tcctccttct tcaacgtata aggctgtccc atcagtagca attatgttgt ttataccaat
     1741 acttatactt ccaccatttt ctatatgtat tactccttct tttcctcctt cacctattat
     1801 attcaattca ttatcatcaa taataaatct cccatgattt tttatcaata ttttatattt
     1861 gttggtatct attgtaaaat tactgtcata aggaatataa aatctaaact cttcatctat
     1921 taccatatca caagaaagag tataaactat ttcttcttta ttatttttat tttcttgaac
     1981 ccacctttca aaatcttcaa gacaattttc ctcttgtcca aaaactttat gtggaaaact
     2041 tataaaacac aaaactatta tactcataaa aataaatatc tcatactttt tcatcttaca
     2101 ctcctagaaa ttttttagct ttgaaacaat ctgtcgaaac atacacttca cccactataa
     2161 tttttccaca attatcaatt attgtcaatt tataaaagta tctttattaa ttgttataaa
     2221 taaaaagcta cttactaaag taaacagacg tttcacttta ataagtagct atatttttat
     2281 aacaaaatag ttataatatt agaacttcct tcatttacaa ttttttgtaa agtcttttgc
     2341 attttaactc ttatctcttc tggcatagta tataatttac tttgtaattg ctcttttact
     2401 aagtcatgta gtgatttacc aaacatattt gattcccata aatctgctgg ttgctcttca
     2461 aatacttcca taagatattt tatcatctct tcaccttgat tttgatttcc aactattgga
     2521 gaaacctctg tagatatatc tgcttttata atatgaagtg atggtgcatt ggcttttaac
     2581 ttgataccat attgttttcc ttgtttcatt atttctggtt cttccagact aagttcttct
     2641 aaggaaggag ctactactcc atatcctttt atcttggcat ctattaaagc actttctatt
     2701 ttatcatact catttttaac tttagatagt ctagttatca gactaagcag ttgataatct
     2761 ccttcaattt taaatccact tttttcttca aggacattat agaataaatc ttgctttgtc
     2821 tgtaaatcaa tatttataac accttctcct agctctacat tatcaacacc tgtatcttcc
     2881 aaaaactcta actcagaaaa tccttgtata ataccttcta tatcccttat tttacctata
     2941 tctataatac tttgttttaa tgttgttatt atgctacttt ttatccaatg atttctttca
     3001 agaccttcaa cccattttgg taagttgatt cttatttctg taagtggaaa atcatataat
     3061 acagcttcca taacctcctc tatatcttct tcttccattt caaccacatt cattggaaga
     3121 actggaactt catacttttc ttccaattca cttctaagca tactcgtttc ctcacttttt
     3181 ggacttaacg tatttaaaac cactgcaaat ggttttttaa gatttttcaa ttcttgtata
     3241 actctctctt ctggttctac atagcttttt ctgtcaattc cagtaactga accatctgtc
     3301 aagacaacta tccctattgt agaatggtct tttataactt ttttagttcc tatctctgct
     3361 gccttttcaa atgtcatagc ttcttgtgac caaggagtgg atactaatct ttgttttcca
     3421 ccttcctcat gccctaaagc tccttcaact atgtatccaa cacaatctac cattcttact
     3481 tttaaagata ctgtgtcttt tatttttatt tctacaccat ctgctggtac aaattttggt
     3541 tctactgtca ttatcgtttt acctgaacca ctttggggta tctcatctct tgttctatcc
     3601 tttttaaatt cattgtctat attaggtata accaactttt ccataaattt tcttataaaa
     3661 gttgattttc ctgttcttac aggtccaact actccaatat atatatcccc ctgagtcctt
     3721 ttggatatat cttcgtatat gttattattc atattattcc tcctatacat ctaatcttat
     3781 taaattatat ttagagttaa gggttaatat tcttaaaata gaaaaataaa gaccagcaat
     3841 attaatttaa tttatatata gaaatttgta aatttcaatg taaattaaat taatattgct
     3901 ggtccaaata gtagtgtatt atattaactg actttagtag tattttcatt tgaattatta
     3961 ttcatctcaa taagttcttt acatctttct tttgtcatgt tcatccatat aaatgtaaac
     4021 accaatccaa ttatggctac tatagtaaga actatgaagt agtacctata tccagttaca
     4081 cccggaaatg catccaatat cttccctgct gctaaaggac aaagtacttc tggaagatat
     4141 cctaacgtag caactattcc tatagcagtt cctgatattg ataatgaata attaccttct
     4201 tcaagtaacg aatagtgtaa accttgaatt gcatacatag atacatatat tgcaacacat
     4261 ccaatcaata gtatataaat catagatgat tttgttggtg taaatattac acctaaaaga
     4321 cctgcaatca taagtataaa tccataagat ataatctttg atgaaccaac tttatctcca
     4381 agtaatccag aagcagctga tgctactggt ctacaatact gagctaatat tgagattgca
     4441 gatgcaaaca ccacagtagc tccaaatgct tcagttgaat aaggcgtaaa ataataaaat
     4501 gacatattag ctgaatatga acaaaacatt attattgtta ttatccatgt atgaggcatt
     4561 tttattactg caaaaaaggc ttctttatca aattttgctg atacctcttt ttcattatcc
     4621 tttaatttga aaaatactaa tactccaact attacattta ttgctgagta taatactata
     4681 atagctgtaa gaccagattc atcacttact tttgatgaaa tatacccaaa tagtatcaat
     4741 actagagata gatgaattgc attggtaatt ccacgaccac tttccataaa tccaaaagct
     4801 tttccttgtt cattttcaga tgctaacatt ctaacagctt ttacaagagc tggccaaaaa
     4861 gtaagtattg ttgttattcc ccataaggca tggattaaaa acacaacaat atatggagga
     4921 taaagtgtta atacaagacc agatattcct gtaataatta aagaacctga aagcaatttt
     4981 ctggctgaaa tacggtctgc taaaaaacca ccaaaaaggt atgataccat tgcaagtaga
     5041 ccataaatgc ttcctaagct tcccatttgt gtatttgtaa gattaaatgc ttgtgcaaaa
     5101 gtatcataat aataattctt taaatatggt aaagcatata taaatgctcc tgctacaaag
     5161 agtattatca agactttgaa atttttccaa atgcttggtt tatttacttc aactgacata
     5221 cttcctcctt atgtaaatac ctgtaaattt tcataataat taattattgc ttattttatt
     5281 gtttattcaa tatttaggaa tatttattaa tatattaggt taatctatca ataatttatg
     5341 gtgagttatg agctaaaagt aaactctttt agctcaccat aataattata tttttattta
     5401 tactaacatc cagagttatt agatatcttt ttttcatagt tcttccatag cattaaacct
     5461 gttattataa caaaaagacc tcctcctatc atttcaatct catagattat attatctttt
     5521 aaagtctcca taactggtgc cgttgagaaa agtatgccaa ctacagttac tacaagtacc
     5581 attctggcaa tattgataca aactgaatca ctttttgcaa ttgaatatgg tctttcttca
     5641 tttggtcttg tctttctaag tctaatataa gatgtaaaaa gcaagacata tggaaataat
     5701 gctgttaatg ctgtcatagt aacaagaaca ttgtatatat tatctactga tggtaataag
     5761 tttgttccta caagaagtag actcactatt atagcctgaa ctattactgc atttgatggt
     5821 atattgtatt tatttgtaac agtcaattgc ttaggaaata caccttctct tacatttcca
     5881 aaaagcatct ttactggacc tgctatataa agtattaatg ctcctagtac tgataaagtt
     5941 attccaaatg ctactattct tataaaccaa cttcctatac ctaaatcttg tgcaacttta
     6001 gctaatgcat ctagtatccc tgtagatgct gcaattttat ctggaggaag tatcattgtt
     6061 attgctactg aacctaagat atagattcct cctattaaaa cagccacagt taatatagct
     6121 ttaggaaagt ttttcttagc attatccatt tcggttatga aattagcagt cgtttcagct
     6181 cctgataatg caaatattat agcagatata gaaactaatg aattggcatc tatttttggt
     6241 attatatttt ggattgtata tatcgatgct gatggagctt ttttgagaat aactacagac
     6301 ataaatgcca tcactataag taatatagca ggaattgtag aacctaatgc tcctgtattc
     6361 gtaaaaaatt ttccaaatgc catcccacga gtacttacta aggacaacag ccaaaatatt
     6421 atgagtgaaa gtgctaaaat aaacatctta ttgtttgata aatctggatt tccaagcata
     6481 tatgcaatat ttatcgctaa aaaagtcaag aaagaagaat accaaaatat ctttgatgtc
     6541 caatttagcc atgacaccat aaatccccac ttctctccat aagcttgttt aacccattct
     6601 ccaagtccac catcttttgg atatgttgca gccaactctg cacatataag tgatgcagga
     6661 acaaagaata taaaagcaaa caataaccaa actggtatag aaccaagacc caatccaaaa
     6721 ctagaggcag tagatttagc tatccatcta atcccaaata gtgctgatat attcataaat
     6781 actaaatccc aaaatccaat tttctttttc actgtaattc ctccaatttc aaatttattc
     6841 agactcatac acaatgtatt gacttaaata tcaagtataa gttcttcaac acttcttgga
     6901 taattagtta taattgtagc accattctta cctactattg ctgtatctga gtgtctaaat
     6961 cctccaactc caggtatata tatccctggc tccatagaaa ataccattcc ttcttctaat
     7021 attaattcat tgtcaaatct taaatatggc tcttcatgtt ctgataaacc taaaccatga
     7081 ccaattctat gatttgaata taactctaga ccatactttg caacaacagc tcttgctgct
     7141 tcatccacca ttcttgctgg tataccagct tttattgtat ctaatccagc ttgttgagcc
     7201 tctactgcaa tcttaaacac ttctttttgt ctttctgttg gtttgcctat aataaaagtt
     7261 ctttcatttt ctgctctata gttttcatac caaacctgtc tactatgtat tactatatct
     7321 cctctttgaa gtattctagt attggaatct aaatgaggtt gtgctgttct atcaatccct
     7381 gaacaagtcc agtttgcaaa tcctatatat gtatcaggat aattttcaga aacatatttt
     7441 agtaaagcat tatcccctgc aacgtcaaac tccaattcac tcatcccaac tctaacattt
     7501 tctaaagacc cttttattcc tatatcagat aggtaacctg ctatcttcaa aaattctatt
     7561 tcttttgcat cttttacata tctcatttca aatattttac ttccaacatc tttgatagca
     7621 aatgacttat cagttatata ctctgaaaag cttgcagata ctatatcttt ttctattcca
     7681 acagttgttc ctttagggta tttatttaaa attatatcta agtaatgttt atgtgatatt
     7741 ccatgttctt tcatttctgg tatttcataa tacacatata cattatcaac ttttgcaact
     7801 tctttagcat gtaattcttc taatccaggt actattaatt ctattttatc ttgagttact
     7861 actgttacaa ttggtctaga ataagttatt gctttaaatc cactaatata aaattgattg
     7921 tctggttcaa atattaaagc aatttcaatg cttttttcat tcatgtactt tctcaatctt
     7981 tctagtctca tattatttga cataatgcac ctctttctta atattcagat aatttattca
     8041 atacaacaag gatgaatata ttattttaaa attcttaata tttttagtac ttgtcgtatt
     8101 tgtatgtaaa ttaattttat ttgtgattat tttatcataa tcatgattat tttgtcaatc
     8161 atgattttat tttaaaaaat tttttatatt ctagtgattt taaattatct aaaatataac
     8221 gagtatacat tgtattttgt aatattattc ttgatttatg gtaagtttaa tgataaaatc
     8281 acgattatat aaactatatt gattatttgt aggtgaataa aatgacaaat aaagaattac
     8341 aaaagaaaag gatattgatg tatttcatag aagctgctca aaatattatg gaaaacgaag
     8401 gtatagaaaa tattacactt cgtaaggttg cagatatggc tggctataat agttcaactc
     8461 tatataaata ctttaaaaat ttagaccatt taatatcatt tgcatctata aaatatttta
     8521 aagattataa cttgaatatt tcaagatgta tagaaaatgt caatgatgaa tataagaaat
     8581 atataattat gtggaaatta ttttgtaagc attcttttga taatgctcaa gctttttacc
     8641 aggtattttt taacttgtct agtgatgaac ttagctatat aacaaaacaa tattatgata
     8701 tgtttccaga agatttaggt attcatgata gtgacatatc tttaatgatt acaggagaaa
     8761 gtataaagga aagaaataag atactattaa acaatcttgt agatactgga tatataccag
     8821 ctaaagattt agacataatc aatgatataa ttatttcttt ttatcaaaat ctattattct
     8881 taaaaaagaa cacaggaaaa aattctgatg atgatgaatt aactatgaaa atgatttctt
     8941 ctattgaata cataataaaa catgctaaat aaaattaaaa tatggctgtc tcaaaataga
     9001 gataagcctt ttttattgtt gaaataataa aaatatattt aatttcatat aaaaaagagt
     9061 gcctcgtaaa ctaaaaagtt cattttgaga cacccctaaa ataaatttat tatttattat
     9121 acaatagttt atatatcatc acctaaaact acttcttcca tttcatgctt tttacttctc
     9181 atcattagtt ctattccaac ttctttagga tttgaacctt tctttattac agaatatata
     9241 gcattagtta taggcatatc tatatctaat ttttcagcaa catcatgtgc tacttcagta
     9301 gcagttatgc cttctacaac catctttact tcttttaaag tatcttctaa actcatccct
     9361 ttacctatga gtataccagc tcttctattt ctactatgca tacttgtaca agtaactatt
     9421 aaatctccaa tacctgaaag acctgcaaag gtagacatat tagctcccat agcaattcca
     9481 agtctgctca tttcactaat acctcttgtc ataagggcag cttttgcatt atcaccatac
     9541 cctaatccgt cacatatccc agctccaaat gctataatat tttttaatgc tcctccaagt
     9601 tctactccaa ctatgtctgg attcgtataa actctaagtt tagggctcat aaataaatct
     9661 tgtatcatct gtgctatttt taaatcttta gaagcaacta ctacggtagt aggaatatcc
     9721 cttgctactt cttcagcatg agatggccca gatagtatta catatggatt ttgtggtaat
     9781 tcttcttcac agacttgaga taatctaagc ccagtccctt tttcaagacc tttagctaca
     9841 ttaacaataa cttgtccttc ttttataaat ggttttattt tttggcaagt acttcttaca
     9901 gcctgtgatg gaactgctaa aactattacc ttacaatctt ttatagtttt ttctatatca
     9961 gtacttatag ttatattatt tggaaataat actcctggta aatagtctgt attttcttta
    10021 gttctgttta tttttttagc ttgttcctct tttcgagtcc acatgctcac atcattacct
    10081 ttttttgcaa gccctaaagc taatgcactt ccccagcttc cagtacctaa tacacatact
    10141 ttctccatgt ttaacaccac ctgagtataa tatatttact attctttctt ttgaccaatt
    10201 tttctctctg tcccatttaa taatcgcttt atatttgctc tgtgattata tattactgat
    10261 gcagttaaga acagagctac tattaaacca gctttatttt ttaccataat cataaatatt
    10321 ggtgaacatc ctattcctac aacagaaccc aatgaaacat actttgttat agctaccacc
    10381 aatataaata ctgctagaca cattagtgtt attactggat ttacagctag cattgcccct
    10441 agtgaagttg caacaccttt gcctcctcta aatcctaaaa ccgctggcca attatgacct
    10501 gctacaacac atataactgc cagatatcca gctaaaagag tatctattcc aaccaatctt
    10561 gctgcaaatt ctgatattaa aacagccatt acacctttaa gaacatcacc taaaaatgtc
    10621 attgctcctg ctctttttcc aagtgtccta agtacatttg tcgaacctgc attaccagaa
    10681 ccttgagtcc ttatatcaac cccagcaatt cgctttgcaa ctatgtatga ggtagatata
    10741 tttcctaaaa gatatgcaac tacagcaata attatataac taaatatctc cactgaattt
    10801 ccccccttta gttatatttt aagatattta ttttttattt ttttgtctat actcaaactt
    10861 tatggaagtt ccttcaaatc caaaattttc tcttatctta ttctcaaggt atctttgata
    10921 tgagaagtga gttaaatcct tatcatttat aaacaatgta attttaggag gtctaatgtc
    10981 agtttgagtc ccatagtaaa tttttaatct tctacctttg tcagatggtg gttgatttaa
    11041 cattacagct tctccaatta cttcattcag tgctgaagtt gatattctct tagaatgttc
    11101 atttgacaca tattcaactg tatctagtat cttgttcatt ctttgattag tttttgcaga
    11161 aacaaatacg attggagcat acatcataaa tggaaatttt tcttttatat cttttgtgta
    11221 attgctcata gtcttattat ctttctctat taaatcccat ttattgatta caaatatgca
    11281 tccttttcct tcatcatgtg ctatacctgc aacctttgta tcttgttctg ttacaccttc
    11341 taaggcatct attactatca atactacatc tgctctatct acagcactca tagcccttat
    11401 tacactgtat ttttctattg tctcatatat tttacttttt cttctaagcc ctgctgtatc
    11461 tattagaaga aatttctgtc catttttttc aaaataagta tcaattgcgt ctctagtagt
    11521 tcctgcaatt ggacttacaa ttactctttc ttctccaagt atcttattga gtatagaact
    11581 ttttcctgca tttggtttac ctgttatagc tactcttatt atatcttctt catactctgt
    11641 atctaatcct gctggaaaat tttcaactat ctcatctaat aaatctccaa atcccatact
    11701 attggctcct gaaactgcaa aaggcgttcc aaatcccaac tcataaaaat cgtatatatt
    11761 atcaaattga ctttgactat caatcttatt aaccactaag attactggtt tttttgtctt
    11821 tctaagcaat tgtgcaattt ctttatcagc agctgttatt ccagctttac catcaactat
    11881 aaaaagtatt acatgtgaca tgtccattgc aagcatggct tgatttctca tttgagataa
    11941 tattatatct tcgctatcag gttcaattcc tcctgtatcc actaatgtaa aatatttatc
    12001 taaccattct acttcagcaa atattctatc tcttgtaact ccaggtgtat tttcaactat
    12061 tgatatcctt tttcctgcaa atttattaaa tattgtagac ttaccaacgt ttggtctccc
    12121 aactacagct acaactggcc tacttatact cattttattt ctccttccat cttttgtttt
    12181 ctattttaaa attttatcca caaaatcttt tccttcattc aaacaaggga taatttttat
    12241 tctcataagt tcttctaatt gatttaattc aatattatct aagaaaattt cttcatctgc
    12301 ttttagcata cttcttgtta tataaagagc ttctcctaat tctttatctt caagttgttc
    12361 ttttaaatcc ttagctgtta aaagacctga tacagttatt gtctctccaa aaaacttgtt
    12421 tttgatttca tatacattta cttgaagatt tttaaacttg tccatcatag catctgccat
    12481 actctgtata aattcatatg cagaatgacc agtagctatt gatactttct tctctctttt
    12541 tagaatcttc tcaggcaata tatttagata ctcttcaatc tctgttttta acttacgtat
    12601 catacctaca ccatcttcaa actgtaaaaa accttcatat tcttcatatc caggcaattc
    12661 actattagat agtatataaa attcatctga taaaaatgca aatcgagtac ctaatttttc
    12721 aagatatttc tgttgtattt gatgtatttg ctctatagtt ttacttgcgc tcttatcatt
    12781 aaatatattt aattctacta gattttctct atgctttgta atcccaactg gaactatcgc
    12841 aacactgttt acatacggat aaagttgagc tagttctttt attgttctat ccaattcctt
    12901 tccatcattt atacctggac ataaaacaat ttgacagttc atttctatat gagcatctgc
    12961 caatctcttc attataccat ataattttcc tgcaaattta ttgcttatca ttttttgtct
    13021 taactctgga ttagttgtat gcacagatat atttatagga cttattctat attttataat
    13081 attatttata tcttcttcac tcatatttgt aagtgtgaca aaatttcctt gtaaaaaaga
    13141 taatctcgaa tcatcatctt taaaataaag agtttctctc ataccttctg gcaattggtc
    13201 tataaaacaa aacatacact tatttctaca gcttttagct tggtcaatta tcggatttgt
    13261 aaattcaaca cccaaatctt catcatagtc tttttctatc tcgtatatgt agacttcgcc
    13321 atcttttttt tgtatttcta catctaaata ttcatcactt agtaagaatc tatactctat
    13381 tatatcatgt attggctgtt cattcacaga tataagtaaa tctcctacct ctatacccat
    13441 ttcttctgca atactatctt tataaacctt acttataata ttatttactt tttttacatt
    13501 tacttccaat attttcacca ctcttttgta ttcatcaatg cttattataa tgtattttaa
    13561 tatgcaattt atttatttat tatattttat gatagcattt ttaagcattt catgtcataa
    13621 taacacattt taattctaat agtcaatata agtaaatagc tataaaatag attagaacaa
    13681 ataatattca aatttaagtt tcttaaaaat ttaaatatta tttgttctta aaaaaatttt
    13741 ataaatttaa tgttttacta tgattaacgt cccatttgtc atatcatgaa ccattccacc
    13801 tacacacttt gacatcaaca atgccttatt ttgtaagtct ttctcatcat ttgcataaaa
    13861 tattggacaa cctccaccat ttttcatatt cttatcaagt gtaactatag ctagggtata
    13921 ttcatttaaa cctatatcca ttcccatctc atgcacttcc tttctttcct attttataat
    13981 tttttagtga taagtttttt cctttagagc ttgaaagtat tgggcatgac tttacagctt
    14041 ccattacttt ttccacattc ttatctactg gtaaataagc aatcattata ctttcatcct
    14101 ctttatttct tctaggtaat ggtacgaatg aaggttctcc ataatctcca tataaaccta
    14161 accttgaata tatattgtat actattgctt gtctttgacc ggagtcaaat aatattcctg
    14221 cattagcata atccttattt ttaggaatta tttgtattcc tacacctcta ttaatatata
    14281 cttctctatc gctttttaga cctatatttg ttataccttt taaatctccc acctttagta
    14341 tagattcgtc cacaaaacta atttcagcag gcattacatc agctatgtct ccaatacttt
    14401 ttctagtaag aagttttttt aatataaagg ctaacactaa tccacaaatt gaacttatta
    14461 ccaaactcat cccttcactt attttcgttt ctgcaagtat tacataatac aatcctattg
    14521 ttaaaaaaga tgtaactata cacatataat ttcttacttc ataggttcta gctatctctt
    14581 ctatgaatgc agctcctctc tttacaagtt gaacttcctc taaattttgc aatgtatttc
    14641 ttctatttgc tctcacttgt ctaaattgtt ctgctgctag agataaaaaa gttatagatg
    14701 tataagaacg atttataaga gctggaacca ataatgctcc taatgaagaa gcgacgaatg
    14761 ctaatataag ttgagatagt aaaacatttg gttgcgttgg atactgtttt tggtctaaat
    14821 tcaacattat aattctagat gttataccaa taataacagc aacaaaaaat actctatcca
    14881 ttaaatcact cctaaaatat ttaatttgaa attttacatg taaatctaca aagtctttct
    14941 agaaaaatca ctctgctttc cttttgatgt ttctatgata ggtgtacttt tcactacatc
    15001 tatcatgaca tctatatctt tgagtattgg catatatggt ataaccacag tacttttttc
    15061 taaattggtc ttagatatag caacaatatc aacctcatct acatctctat ctatccccat
    15121 atgaataaat agattatgta ttatagcttg tctttgccct atatcattta ctattccaaa
    15181 tgcacctaaa tctcttggta taacttctat ggccagacat tcatttctat acttttctct
    15241 tgtactttct agacctatgt tagttattat tacaccattt accattaaaa taggtccttc
    15301 aaaacttatt tttgcaggaa ctatatctgc tatatctgct atactgttcc ttcttaaaaa
    15361 tcttctaaaa atcaaaccaa caatagctcc tgacacaata gctaggattg tgcaataaaa
    15421 aaagctaagg ccatactttc ttgcaaaaac gatataaact atcgaagata ccagtgcaga
    15481 aaaaagactt atataacttc tagattcata cgtagatgct atttcttcaa cgtaagcgtc
    15541 tccttttggt actaattctt cattatcgat attctttagt gttattcttt cttgttctgc
    15601 aagaccttga aactgttgta ttgctactgc aaaaaatgtc aaggctgcaa actccttatc
    15661 tataagtgca ggtaatgcta tagcacctaa cgaagctgaa agcccagata taattatctg
    15721 ttctaaataa tcttgtggtc ttgatgggta ttgtttgtct gtaactctta aaactaatcc
    15781 tctacataat attcctacaa ctaatgcaac tataaaagag tgtctaaata aatttgcatt
    15841 caataaactt tcttccattt tctcagctcc ttctcttata tagtttgtgc aaaaaacaaa
    15901 aaaaattccc ttctatttaa ggaaattttt ttgtaatatt gtaactataa attcgctacc
    15961 aatgccaagt tcacttttta cttttataca tccatttagt gatttgacta tatgctttgt
    16021 tatagccaat cctaaacccg ttcctcctac atccctactt cttgctttat ctaccctata
    16081 aaatcgttca aatatgcgtt ctacatcttc ttttggtatc cctacaccat tgtctataac
    16141 tttaattacg attttttctt catcttttaa cactacaact tgtacaatcc cattatcttg
    16201 ggtatacttt atagcattat caactaggtt taagaacact tgctttatat agtctttatt
    16261 ggatagtata cttattgatt tatcatcaca tttatataaa acttctatat ttttttcact
    16321 agctgaatgt tgagttattt catatacctc tttaaataca tcatatacta caacattttc
    16381 cataagaaga gtatctttat tttctacaaa tgataacagc aatatatcat caatcaacct
    16441 ttttaatcta tctgattcgc tttctattat ttctaagaat ctatttctag tattcacatc
    16501 tatattttca tttgacttta gtgtttcaac aaacccactt atagatgtaa gtggtgtttt
    16561 aagttcatga cttacatttg caacaaaatc acttctcata ttttcaagtt taactttttt
    16621 agtaatatct tctatattta ctatcgaacc tattattacg ttgttagtat tctgaagata
    16681 aactgggtct acttttatct tatatacgat atcatcttta gtagtaatat tagcagtttc
    16741 attatcttta gaaccaataa attgaagtat ttgttttaat atttcttctt cttttattac
    16801 aacattaata ttatgacctt caactaattg atttggttca ctctttatca tttcttttgc
    16861 ttcatcattt atcagaagta tatttccatt tacatctata gccaaaattc catgagatat
    16921 actctttaat atagacctta actgtaaatg tttatactgt acttcttcta aggttttatc
    16981 catattcttt atcatatgat taaaatttct agctaattcg ccaagttctc ctttggctga
    17041 tatgttaagc ctagcatgat attcattatt acttactttt tttgagacgt atataaactc
    17101 ttttaaatat ttccttaatg ttattgtgta tcttacagct aatataacaa tggctatgga
    17161 caacataaca ataaaaaaat atatactatt taaatcttcc acaagataac actcctaaaa
    17221 tataaccttt ttaatctatt ttgtatccta cacctcttat agtctctata tatttttccg
    17281 atttatcttc atcttctatt ttttttctta aatatcttat atgaacatct actgttctag
    17341 tttctccata gtattcatac ccccatattt tatccaaaag ataatttctt gaaagtactt
    17401 ttcctttatt ttgaattaat aattttaaca attcaaattc cttaagagtt aactctatct
    17461 tttcagagcc tttggtaact tcatgttttg ataaatctag ttttaaatta cctgtagtaa
    17521 gtatattgtt ttcttcacct aagctagtca aattatatct ccttaaaaca gaactaatcc
    17581 tagctaacaa ctcttttata ctaaatggct tagttatata gtcatcagca cctatttcaa
    17641 gcccttcaac cttgtcattt tccatatttt tagcagtaag cattataaca ggaatatttt
    17701 ttaagtcctt atcacttctt atttttctca aaacttctat tccacttata tttggtaaca
    17761 tccaatctaa aagtattaaa tctggtttaa tttccttagc ctttataaat ccgtcaaatc
    17821 catcatatga ataactaact tcgtaatttg acacctccaa attgaatttt aatagctcaa
    17881 ctatatgcat ttcatcgtct ataacaagca ctttagtatt cattaaaaag ctcctctcta
    17941 ttttatctgt agtaccgttc ctattcgttc tgatgcctta ttatgttttc tataagagtg
    18001 gaatttatct gctctacaac tagtgcataa atttaaattt attatatttt cttttttaac
    18061 tccactacat ctaagcatat actcattaat tttccataaa tctaaatagt aacttccctc
    18121 ttttattata tagaactttt catcattatt tgtaagaatt gtgttaaatt tttctactaa
    18181 atcttcagac acttcataac aacatggtcc aattgatggc ccaattatac atactaaatc
    18241 ttcaggaact gttttatagc attcagacat taattttatt gttttatgac ctatattact
    18301 aaaagtccct ctccaacctg catgagccag tcctatggct ttatttttag catctataat
    18361 tgatataggt acacagtctg ctgtaaacag taaaagtggt actttttcca agtttgttat
    18421 aagtgcatct ccatctcttc ttttccctat agtatcttta ttgactatat taactatatc
    18481 tgaatgtatt tgagaattac tagttagatt ttcaaatgtc aaatcacatt ctttacatac
    18541 ttttaacata tcttctctat tttttgcatc tatattctta catgttataa ctagatttac
    18601 agaatttaat ttttcatcaa gttcttcaca attaccactt aaattaacat actctttaat
    18661 atcttgtaca ttttttatat ttatataatc tttcatcatt tgtctccttt ttctatcagt
    18721 atacttttaa gttcatttac aaaagtattt atatctttaa attgtctata cacagaagca
    18781 aatcttacat aggcaacctc atctaactct ttcaatttat ccattaccat ctcaccgatt
    18841 tttttggttt caatttcttc tataaaacat ttatttattt cattttcaat atgtacaaca
    18901 atactttcaa tctcgtcaat agaaacaggt cttttttcac atgcttttag caatccatat
    18961 tttatctttt ctctatcaaa atattctcta ctattatcct ttttaatgac cattaaagga
    19021 gttgtttcta ttttctcata cgtagtaaac ctctttttac atgattcaca ctcacgtctt
    19081 cttctgatag attttaaatc tgtatgtcta gaatctatta cctttgattc tttataatta
    19141 caataaggac attgcatcta tattcctcct ttgtttaact atatctcaaa ctcatctaag
    19201 cttaattctg aacctatatt tactattatt gtatcacaac ctattttaag tatatcattc
    19261 caaaatataa cttcttcatc ccctcctctt gaaaaaaaac ttctacttcc atctccaaaa
    19321 atggtaaatg agactacctt accttcgtga atatccatgt ctatgtctat tataaacccc
    19381 atcctttttc cattttttac atttataatt tctttttcca ttatatcaga aactctaatc
    19441 atattgtact caccctttct ttaaaaataa atatgtatcg aagtaaaaaa aaatgaccta
    19501 tataggtcat ttaaattaaa ataatgttta cagtccatgg attacttata catattttct
    19561 catatttttt aaagcatttt tttcaattct tgatacttgt gcttgagata taccgatttc
    19621 atcagcaact tctatctgag ttcttccttt gtaaaacctt aaatctaata ccaacttttc
    19681 tctactattt aatttcttaa tagcttcttt aagtgatatt tcttgcaacc aattttcatc
    19741 agtatctttt ttatcttgaa cctgatccat aacgaatatt gcatctccat tgtcttgata
    19801 tactgggtca aacagagata ttgggtcttg tatggcatca agtgccatta caactgattc
    19861 tacttctaat tctaattcct ttgctatttc tgatactgta ggttctttag aatttgttct
    19921 aattaatctt tctctaactt gtagtgcctt atatgctata tcttttaatg acctacttac
    19981 tctaattggg ttattgtctc ttagatacct tctaatttct cctataatca taggaacagc
    20041 ataagttgaa aaccttacat tttggcttaa atcaaagtta tctatagctt ttataagacc
    20101 aatacaacct atttgaaata aatcgtctat attttctcct ctgttgttaa acttttttat
    20161 tacactcaag actaatctta aattccctct tacaaactgt tgtctggctt cttcatcacc
    20221 attttttatt tgtaataaaa gttccttcat ttgcttattt ttaagaactg gaagttctga
    20281 tgtattaaca ccacatattt caaccttatt aacttgcata tattttcagt cctctctcaa
    20341 aagtattcat ctattgaaat tatttacatt tccaattttt ttatactttt taagaagaat
    20401 taatttagca ttatacaaat tttttcattt ctttttgcaa ccttgagatt attttctttt
    20461 caagtctaga tatgtaggac tgtgatattc caagcattcc agcaacttct ttttgtgttt
    20521 tttcaatacc tttatcaata agaccaaatc ttaattccat aatttgcttt tctctgtcac
    20581 ttaatctgtc aagtgccata accaacaaat ctctatctat ttcttcttca attattttgt
    20641 atatttcatc attttctgta cccaatacat cagataataa aagttcgttt ccatctaaat
    20701 ctatatttaa aggttcatca aatgatactt ctgttttctt tttattattt tttcttaagt
    20761 acattaatat ttcattttct atacatctcg aagcataagt tgccaatttt atatttttat
    20821 tcagtttaaa agtattaact gcttttatca aacctatagt tcctattgaa atcaaatctt
    20881 ctacatctat acctgtattt tcaaattttc tcgatatgta gactactaat ctaagatttc
    20941 tttctattaa aattgacttt acactttcat ctgtttctag cttttgtaaa agctccattt
    21001 cttcttctgg tttcaatgga ggaggaagta tatttgcccc tcccatatag tatattccct
    21061 ttggctttat tatttttaat ttaataccta acatagtaat aaagcttatt attctttctt
    21121 tcaatcgtaa cattccttgt cccccttaaa ttttcaccta aaatccaggc aatatatttg
    21181 gattcattat tgctccatat tctctatcat taaaatttga aataccaagt attatatttc
    21241 ctatcttttg ctcatctact tctatatagt cagcttttaa gcctattatt atgcttgtct
    21301 tattacttcc agcatgttta taaggtatta ttctaactct acctgaagtt ttatcatcta
    21361 aacttcctat aatttcttgt gctttcttca tatctatatc ttcataatta atatttaata
    21421 gtttttctgg aataaatcct tctaacacac tagacttaac tattattaca tcactttgac
    21481 ttattgggtc ttttaacaaa ttaccactat ctactaaagc cttacagcaa aaactttttt
    21541 ctagtaagtt tatatttata gtctttgtaa gctccttaat gtacttaagc attttcaaat
    21601 ctttataaat gtattttaat aattcacaac tcacataagt acatgcaatt aagaaagata
    21661 tttttaagtg acttattcct gtaaaataaa ttataaaata agtgcttcca gaaataaaaa
    21721 tgtttactag ataaaaaact aacgctacat gaacataatc ttttttgctc ttacttctaa
    21781 atgaaattaa agttattata ctcatgatta ttattttaaa tggtacagta aatagtatat
    21841 tcattgatgg atacaaataa gcaacagaat aggcacctcc taaactagcc cccaataact
    21901 tatttttttt aggattatat cttttagtaa gaatagaagt acaacttata ataatataat
    21961 ttattactag gttttctata acatagtact caatatacac catgtatccc cccttaaaac
    22021 ctttaaacat attataagat agtatgtaca aaattttatg tcacttttga tggtcgaatc
    22081 caaaacaaat tctatttaaa aagaacaatg atatatgtct tatactttat gtcgtcaaaa
    22141 gatatttttt taataccaaa caaatagact tttttgtaga atccaatata tctaggtaga
    22201 agttattcac tctacttttg gtatatttac aaaaaaagac tacataattt aataatatat
    22261 caagtaaatc ttttacttat ataaaatcaa attatatagt ctgtaaattc aaatataaat
    22321 tattgtgcta gtaatccatt tgcatatttt gcagattcat ttagtgcttg ttctggagtt
    22381 atgtctccag ctatcatcat ttgaagttgt ttccataaat attcatatat ctctactcca
    22441 tgaggtccaa ctgtcaatgg tctatacata tgtttatctc ttgtcaccat ttcttcaaat
    22501 cttgggtctc cttggtattt ttcaccttta gcaactggag ctctaggtat ttctttgtgg
    22561 aaagcttcca ttgattcttt gcttagcata tactcaagaa gtttaaatcc aagttcttta
    22621 tttttacatg ctgacattaa tgttaaatca tctactgaag caaaacttcc aactgtctta
    22681 tcttctaatg atgttacata tccccagttt aaatccggga atgatttatc aaaagtactt
    22741 gtagcagcag aggatagcat tatagtaaat gcagcttttc ctggtccaaa tacactttca
    22801 atcatttcat tactatcttt tgataaagca tcttctggaa tatacttttt catatcattt
    22861 ataaagtttg cagctttcaa gccttctgca ttattaaatt taactgattt taaatcatca
    22921 ttatatatat ctccaccagc ttgccataaa tacggatacc agttccagtt taagcttcca
    22981 aatactttag aaccccaacc ttgtgcaaga ccccactggt cgatttttcc atctccatca
    23041 gtatcttttg ttgctttttc acagattctt ttaaaatcat cccatgtttt tggaggtttt
    23101 tctcctaatt tttctagtat atctttattg tagtacaata cgcctggatt agcagcttct
    23161 ataggtaaac cataaatacc acccatcatt tttgcatcat ctaagtatag ataattatct
    23221 gaagttcctg atttttctaa ataaggtgtt aaatcttcta ccgcacccat ttctataaat
    23281 tgaggaaaca tctctgcata catgtatcct atatctggac cttcacctgc acttattgct
    23341 gttgcatatt tttctgcgta gttatcccat ggtactatct gaaattcaat ttcacagtta
    23401 ttttcttttt caaatttttc aaatatcggc ttccatgcat ctgcatcatg gtctgttaat
    23461 ggtgcagacc atacaactaa tttttcttta ccctctttgc ctttagaatc ttcttttttt
    23521 gaacatcctg caagaattga tactgataga atccctacca taactaaaga aagaaccttt
    23581 tttagtttaa tcatgcttaa tcccctttca gactttaatt tgtctttttc ctcaaatgtt
    23641 tacatttaat tcagatttaa tattaacaaa taagattact cttgtctaat cataaaaaac
    23701 tatactaact cctataacta tatttttttt ctatacctat tagatttaat tcatactaaa
    23761 aacttacttt ttaaatttta tcaatattta aaaatttttt taagtctagc cacaaactaa
    23821 ctatctaaat tgagcaaaat aaaaagaagt ctattgactt ctttataagc ttacatatta
    23881 tcttcttctt cttaggaatg taggtatctc catgctctca tcatcatctt cttcaattat
    23941 acttgccttt ttaggaggct ctattttttc ctcagcaatt acttcttctt caatttcttt
    24001 tacagcttgt tttactgttg tatttaatga agaacgtatg cttgatttag gtttagtatc
    24061 taaatctaag gcaccatttt gtaatccttc aaatcctgtc gcgattactg taatcattat
    24121 ttcatcacct aaatcttctt ttatagaagc tccaaatata acatttgctt ctgggtcaca
    24181 ggattccata actaaagttg atgcctcatt aacttcaaat aatcctaagt taggaccacc
    24241 tgtaacatta agaagtactc ctttagctcc ttgtattgat gtttctagaa gtggagattg
    24301 aatagcttgt cttgcagcat caattgctct agtttcacca ctagcactac ctatacccat
    24361 atgagcaagt cccttgtctt tcattatagt agtaacatct gcaaagtcca agtttattaa
    24421 cccttcaact gctataaggt ctgaaattga ttgtatacct tgttttaata catcatctgc
    24481 aactgcaaaa gcatctaaca ttgatgtatt tttttgtact atctgtaaaa gtctatcatt
    24541 tggtatcgtt ataagagtat ctacttttga tttaagttct gctattccac cttcagcgtt
    24601 cttcattctt atcttacctt caaatgcaaa aggtttggta actacaccta ctgtaagtat
    24661 ccccatttct tttgccaagc ctgcaaccac tggagcagct cctgtaccag taccaccgcc
    24721 cattccggct gttacaaaga ccatatcagc tccttgaagt aactttacta tttcatcttt
    24781 actctcctca gcagctcttt tccctacttc tggatttgct cctgctccaa gtcctctagt
    24841 taatttttct cctatttgaa ctttatattc agcttttgat gtatataaag cttgtttatc
    24901 tgtatttact gatataaatt caacgccttt tagttgagct tctaccattc tattgacagc
    24961 attgtttcca ccgccaccta cacctattac tttaatttgt gcacattctt ctaattctac
    25021 gtcaaagttt agcatcataa acccccttct ctcatgattc aaagttatcg tatgtattaa
    25081 ttatatcatt ttcttctttt attttgttaa cctttaagta acatattcca caaaaacgta
    25141 aattttcctt tttaaatttc ttacttatat tgtcaaatat tactctttaa gtataaaata
    25201 atttacgtat atattaaatg ctctttaatt tttacgtttt ttgttcataa tattactaat
    25261 aatatatcgt ctaattatag ataagttatt aaacaatctc ataccaaaaa ctaatacagc
    25321 aacatagtaa agagaaactc ctaacttttc tcctatataa gtcaataata tagccaatat
    25381 agcattacct atgaaaccag taataaaaat tacattatca tagttatctt caaaattgga
    25441 ttttatcgct ccaaaaatag aatccattat tgcaagaata gctactgaca tatatatgga
    25501 ataatccata gaatatgtaa atggaatata gtaacctact actacaccaa atgctaatcc
    25561 tcctaaaacc cataacataa atcttcacct ctttatttta ctttgaaaca caactacatt
    25621 acaatccttt ttattaattt tttttacttt ttctttattt ttttgtattt ttcgttttat
    25681 tttgcaaata aatccacttt atttccatta ttttcctgaa cttttatatt aattccatat
    25741 atatccttaa gagatttagc atatgattct ggagagttta tagctgcact caataaatct
    25801 atatctccta tagcttttat tataaatggt tgtccatatg tagtatcatt tactgtaata
    25861 gtagctcctg aacattttat cttacttgtt gctagtactc tttctccatt tatagaaatt
    25921 gctcttgctc cagccttttt taaatcattt aaaaccctca aaatatctat atcatgtata
    25981 atcaaatcgt ttggattctg tccgtctttt aactctctct cactatccct catagtaata
    26041 gttatgcctg gccctgtaac agttgaataa ccacttaatt ctttaacttc ttcaagctct
    26101 ttttgcataa gtgtttggat agattcattt ccattctttt ttgcttcttt atattcattc
    26161 aaagtttttt tgttgttttt aagagtttct tttaaatttt ttatttcttt ttttgtattt
    26221 tctacctcac tttcaatact ttcagtttga cctaatgtta tgtatactct atttgggtct
    26281 agtgatttta tataagttga tatgaaaacg cctaatatga atgctcctaa tataactatt
    26341 ttctttttca tactattatt tcccctctgc tttgtttata tcactatgac catttatttc
    26401 tatattgtct tctttggtca cttttacttt ggcattataa tatgtttcta tttcccagac
    26461 aataccatac tttatattaa gtgccgaagc caatgtatca gaatcaccaa ttgcttttat
    26521 tataattggt tcttttatga cagtgtcatt catataaagc ttgtcttctt ttaaatacat
    26581 atatgtatta gaaactattc tctggtcgtt tatagatatg gcacttgctt gtgctgaatt
    26641 taatttattt atcattgaca ataataaatc ataattatat agtatactat catttttatc
    26701 agagtttcct aagtcttttg tagaatttat ctcaattttt atgcctgttc cttcaacatc
    26761 tgtatatcca gctaatgttt catatttttc tatttctgac ttaagtatgt cttgttctcc
    26821 ttcattgttt ttgcctctat aagtctctat atctttcttc acactattaa cttctgattg
    26881 tagattctct ttttcttttt ttaaagattt aagttcttct gtaagttgct ctcctctttt
    26941 aaaagttgtc atccctctat tttctatatt aataatttta agttgtaaac taacaagaac
    27001 acccaataca atacttccta tgattatact tttatttata aatctttttt tcaatatatc
    27061 acttccttac aattgtctat ccttctggac tatacactgc caactttcca tagttaagat
    27121 ttatagtccc tccattagta tttttatttt gcaggtcaat cagaatttta cttaccctag
    27181 atatattata atctaagtta tcatcattag aaagtaagat ttttatatta cttcttgtaa
    27241 gcatttctat attgctttct ttttttaagt ttacataatt tatttttcta taaattcctt
    27301 cttcttttaa ataatttaaa gttttaaata cattctcctt agttttataa tttttaaatt
    27361 ttatagattt attatcatca atgctataat ctacatctac tatcaagtct tttttacttt
    27421 cattagaacc tcttagttct tccaataaat ttcctttttt atctatataa caataattat
    27481 cttcatcttt taatactgca aatatttctt tttcttttaa acttataatt atcttattgg
    27541 gaagttttct ttttatttcc acattttcta tatatggatt ttttataagt ttatttttca
    27601 tatctttaaa attgtatgca aaaatatttt catttagatt tacatttagt tctttcatta
    27661 tatttgattt ggtcaccctc ttatttccaa ttacatctat tttctttaca tcaaataaat
    27721 cactttttac aattatacat atacaaaaag ataacataag tataaaaact aaaactatca
    27781 tgacattatt cgtatttaac tttcttcttt ttttcaaata taatcaaccc ctttggttaa
    27841 taaatacacc tttagagctt gtttttccta caaaaaaatt ataatattta aagtcaaatt
    27901 tttgcatttt attacataac atccaaataa ggtattaaat tttataaata aatcaatatt
    27961 tcatcaaaat aaacatagca tactacatac tatttatata tttaaatctg tatacataca
    28021 aataaacccc taatttataa taatttagaa aatctaatat attataaatt aggggtaaat
    28081 atttacttat cttttcttta ttcctattac cttagcttga ccttctatac ttggagtcgt
    28141 ttcttttttt atttctttta cttccttaat aactttttct ttttttgttt ttttagaagt
    28201 tgacttttgt gttgaattgt atactttcat tatctcatca tatataaggt ctatggcttc
    28261 aggcttacct atagttttac ttgcatttgc catatcaacc aaaagttctc tatctcctaa
    28321 aagtttaaat actgctgtat ttaggctctc tggagttaga tttttttcta aaatagcaat
    28381 tcctgcccct tgtttttcta tactcttggc attatactct tgatgatttt cagcagtata
    28441 agctttaggt attattatag atggctttcc aagagccgtt atctcagcta atgaaattgc
    28501 tcctgcgcta cctataacca aatcacttgc tgcaagtgca tttgccatat cttctaagta
    28561 aggcacaact ttttggtatg gtttaagatt tatatcgcta atacttccca taaattcatc
    28621 ataatagctt ttgcctgtag caaatataaa agctatatct tcatttacca tattctttat
    28681 tacaagtctc attgcatcat ttatttttct tgaacctcca ctaccaccat agcaaagtac
    28741 cattcttttt tcgtcactta ttgatagatt ctttcttgca atattttttc ttgataataa
    28801 aatttctttt ctaactggat ttcctgtaaa aactaattta tcttctgctg cctctggaaa
    28861 tcttttatgc gaatcttcaa aacttgtaag tacctttgta actgttttag ataaaatctt
    28921 attagttaca ccaggaaaag aattttgctc atgtattatg gctggtattt tccccataga
    28981 tgcattaaat aaaacaggtc cactaacata tccaccagtt cctataacta tatctggttt
    29041 aaatttctta acaatctttc ttgattgctc caaaccttta aaaagcttaa aaactctttt
    29101 tacattatcg aaatctattt ttcgcttaaa accttgaact gttacagtct ttaattcaaa
    29161 tccatactta ggaactattt ctgactctat tcccttttcc gtcccaacaa aaattatctc
    29221 agcgtctgga tgctcatctc ttattttgtt tgcaatagct atagctggat acacgtgccc
    29281 tccagttcca ccgcctgata ataaaacttt catcaaatca tcatctcctg ttaattaatt
    29341 ttgacatgct ttgagatgtt taacactatt cctacagctc ccataaagat ggtgagtgaa
    29401 gttcctccat aacttataaa tggtagtgct acacctgtag ctggcattga tgatgtcgca
    29461 actgctatat ttaaagctgc ttgtattcca atttgtgcac ctatacctat aacaaccata
    29521 caagcaaata cattagaagt cttcaaagct attcttacac atctgtagac taaaactaca
    29581 aatagcataa taactattat acaaccaatc aatcctaact cttctcctat tatagcaaat
    29641 ataaagtcat tttgtggctc tggtatataa aaatactttt gtttactctt tcctaagcct
    29701 agaccaaaca atccacctga acctagtgca tatagacctt gtattacctg atacccctta
    29761 ccaagagggt cttgaaaagg gtctaaaaat gatgtaacac gactaagtct atagggttca
    29821 gcaattacta atgcagcaaa taaagcagcc ccactcccta tcatagcaaa tacaattttc
    29881 atatccattc cagcaacaaa tatcattaca aaagtaacta gaattacagt acctgctgtt
    29941 gacaaatttg gctgaagtat tatcaacgca aaaaatatcc ctggaactac gagaagtggt
    30001 acaacacctt ttgtcaaaga ttttatttta tcataatttt tttcaattaa ttttgcagtt
    30061 aatattattg tagcaaactt tgcgatttct gcaggttgaa atgttaaagc tcctattccc
    30121 aaccatcttt ttgctccgtt tgcttctatc cctaaagggg tcaaaactaa caataataat
    30181 actactgcta tagctccaat tgctgtagca tttttcttcc aaaaactata atctattctt
    30241 gatgtaataa tcataactat aaatccaagt acagcatata ttacattctt ttttagaaaa
    30301 tagtacgcat cattgtgttt aaatgaagat tgtataaaac ttgcactaaa caccataact
    30361 attcctacaa atactaaaag catagtagtg taaaacacta ctccatcaaa ttcagtcttc
    30421 acccttatgt caatttgttt tttcaaattt tctttaggca tccaactaat ctacctccat
    30481 tcttccattt aagtaagttt agaggtaaga gattatttta aattgtttac attatctttg
    30541 aagtcttttc ctcttacttc aaaactttca tacatatccc aacttgcaca agctggtgaa
    30601 agaagcacta tatctccact ttttgaaatt tcataagaag tcttaactgc ttcttccata
    30661 tcttttacta tatgtatgtc attaaatcct ttatttttag cacaattttc tatatttgat
    30721 gcagtttctc ctaataagac caatgattta acatatgact ttgcagtttc aagaagttca
    30781 tcaaaattac ttcccttatc catcccccct gctataagta ttataggtct atcataagac
    30841 tgtatagctt ttatagtgga atctggatta gttccctttg aatcatttac atatattaca
    30901 ttgtctaaat ttcttacaaa ctcttgtctg tgttccactc ctttaaatgt cataagtaca
    30961 tcctttataa cttctaaatc aattttgcag acatatgcta ttgctatagc tgccatacaa
    31021 ttttctaagt tatgacctcc aggtaaactt acatcatctt tatttagaaa tttgatttta
    31081 tcatctatat ctattattat gtcattattt tctaaatata ctcctccatt tactttttta
    31141 gttcttgaaa agtaaattac tttggcattg catttatcag ctaaagattt tactatctca
    31201 tcatcatagt ttaatacaca gaaatcctca acagtttggt tcataaatat atttgccttt
    31261 gcttctatgt atttttccat agtatggtgt ctatttaaat ggtcctctgt aatatttaat
    31321 attgcgctta ctttaggtct aaattcatct atactctcaa gctgaaaact gcttagttca
    31381 gttactaaca cagactcttc acttgaagtt tctatagtat ctattacagg atttcctata
    31441 ttaccaacta catatgtatc tcgttttgct cttgaaaaaa tttctcctac caaactagtt
    31501 gtagttgtct ttccatttgt acctgtaatc cctataaaaa ttggattatc cgatagttta
    31561 aaagctaatt ctacctcacc aattatatac ttgcctgaat tttttaattt caatatgaat
    31621 ggtaggtcta gtggtacacc tggagacact acaaccatat ctatatcatc tacatcttct
    31681 gggtgatgtc ctaatatgta ttttatgtca tttatagatt tcaattcatc aagtatattt
    31741 ctcaatttat tttcatcttt tatatcattt acgattatac ttgcacccaa tttatctaaa
    31801 tgtttaattg tagatatacc agtttttgca agtcctacta ataaaacttt ttttcctttt
    31861 aagtccattt ttcattcccc ctagccctaa aatactgcta ttatacttat ccaagctaaa
    31921 acaactgtta taatccaaaa aataaataca actcttgttt ctggccaacc acactgttca
    31981 aagtggtggt gtattggagc catcttaaag aatctctttc ttgttgcctt aaaatatcca
    32041 acttgaatca aaactgatag agcctccgca aaataaattc ctccaattat aggtattata
    32101 agcactgagt tagttagaac tgaaaatgct acaactgcac ctcctaatgc cattgaacct
    32161 gtgtcgccca taaacactct agccggatat gaattaaatc ctaagaaacc taaacatgct
    32221 ccaacagttg ctgctgctaa aactgcgact tctgtatttc cagcaataga acttgcaaat
    32281 agcataaaga atacagaaac tattaatgtt actcctgatg ctaatccatc taatccatca
    32341 gtcaagttta cagcatttac tattgctacg attataaaca tcattattgg tatatataat
    32401 attccaacat ttatcacaaa atctgtaaat ggtatcataa gttgtgaagc acttgatgat
    32461 gatgtatact gataaaaagc aacataaaaa gataatgcaa cttgaaggat tattttttga
    32521 tatgctttta gtccaagtga tctttttagc tttattttta taaaatcatc taaaaagcca
    32581 ataaaaccaa aacctgcaat acatataaga cctactgcca tatcatgact aacttttact
    32641 cttgtaagtc cagttattag aattgcaaca atcattataa ttccacccat agtaggtgtt
    32701 ccgtttttag ctagatgtgt ttggggtcca tcatctctaa ctgtctgacc aaatttaaat
    32761 tttctaagca ttggtataaa tattggtcct attataatta ctattaaaaa cgcaatcaat
    32821 gcggtgtacg taagctctgt tattcctaac atcataaaac tcctctccct tgtcaattaa
    32881 ctcattagtt taagcttatt tatttagata ttcgactatt ttttctaatc tcatgcctct
    32941 tgagcctttt actaaaatag tgtctcctgt ttttactaat tcatttaact tgttaaacac
    33001 atcttctcta ttctcaaagt gatatatatt ggctgaattg aatcctaatt gttttgcttc
    33061 ttctccaata aacactgaat tttcacctat agttattata atatcagtat tattcataga
    33121 tgattttcca actaatctat gaccatactc tgaaatttca cccatttcta gtatatctcc
    33181 aagtatcgct acccttctac ctttatatct tccaagtatc tttaaagcag catccataga
    33241 atctggacta gcattatatg aatcattaat tattgttaat ttttcatttt ttattatgtc
    33301 tagtctcatt tttgtccctt taaaattttt taaacctttt tttatataat ctaaagaaat
    33361 atttagacac aaaccaacta atatagcaga cattgcatta tatatattat gttctcctat
    33421 tgttggtata aatatttcct cttttttccc atctattaca catataaatg ttaaactatc
    33481 ctcttccata gtataacttt cacaataaac atcattgttt ttattaaagc caaatgtttt
    33541 taacttatat acatgttctt tttcttttaa tgtagataaa aacttatcat ctccatttac
    33601 aattaaagta tttgtttcat caaagtttga agtaatctcc atctttgctt tcaaaatacc
    33661 ctcttgtgaa cctagttttt ctacatgtga taatcctata ttcgatatga ctgcaatttt
    33721 aggatttact atatccacta aatattttat ttcattgaat ccagacatac ccatctctat
    33781 tacagcacac tcatgttctt tatttagatt aaataaagtc aatggaactc caaaatgatt
    33841 atttaagttt ttttcatttt ttagtatatt taactttgca gatatggcag agtaaatcat
    33901 atctctagta gtagtttttc ccacactacc tgtaacacct ataaatggaa tatcaaattt
    33961 ttctttatag tattttgaaa tatctcctag agccaaagat gtatctttta cctctattaa
    34021 atttatatcc gaactttcta attttattcc attactttca ttttttataa aagttttaca
    34081 tccactatca tatgcagact tcataaatgt atgcccatct aaattttctc caactatggc
    34141 tacaaatgca ttttgggcat ttgcctccct gctatctata actatatcac ttacacagtc
    34201 attataatct ccatatatta acttcccatt agttgcaagt actaactctt ttattgttaa
    34261 gcactccatt attaaactcc tcctttaaaa ccttagctat attctcttag caacaaaagg
    34321 caatgtatac cgttatatat acattgccta cgataactct taactttata attatatact
    34381 atatttctgt ttttttgaag atgtttatgg gtatatgtta attatctgtt actttttagt
    34441 tttcaaaata tagggttata cttgagtctt cattaacttt tactccaggt tttgggaata
    34501 tatcctttac ctttgtatct tctggaagtt ctatatctgc atctaagtct ggttttaact
    34561 tcgcatcctc caatgccttt acagcatctc ctatttttag atttcttaca tctggcactt
    34621 taacttgctt cttttcatac tcagcttttt cttcttcttt atatactggt ttaactccca
    34681 aatattttaa agagtcattc attatttctt tcactattgg tcctgctgta gtactaccaa
    34741 atgcacttac tcctgttggt tcgtcaacaa tagcaagaac tactatttgc gggtcatcac
    34801 aaggtgctat tccaacaaat gaacatatat actttcctgg agcatactta ccatctataa
    34861 ctttttgagc tgtacctgtt ttaccaccaa gtctataacc tggtatatac gctatctttc
    34921 ctccaccttc agttacaact gattctgcaa tttctaacat ttttttagat gtttctttag
    34981 atataacact tcttactttt tttggtttta ctgtttcagt tatatttcct ttattgtcag
    35041 tataagattt taccactctt ggttgcatta aatctccacc attagctatt gatgatatag
    35101 ctgttataag ttgtattgga gttactgata tagattgacc aaatgatatt gtagccaatt
    35161 caactggtcc tacatttttt tcgttataca gtattccctt agcttctcct ggtaaatcta
    35221 tacctgtctt atccataaga ccaaatgatt ctatataatc atacattttt ccaacaccta
    35281 atctgcttcc taactcaaca aatactgggt tgcaagagtt ttgtactgct tgtttaaatt
    35341 cttgtgttcc atgaggtctg taatgtctcc aacatttaat ctttcttcct ccaacagtta
    35401 cactacctgt acatgtgaat ttttctccat ctttaattac tccttcttca agagcactgg
    35461 aagatgtaat aagcttaaat gtagaacctg gttcatatgt atcacttact gctggatttc
    35521 tccacatttg ataatagcct tttattttat ctttatcatt atatttttca agttcttctt
    35581 gataatatgg atatattggc gtccttgagt cattagggtc ataatctggt tttgatgcta
    35641 aagcaagtat atcacctgtt ttagggttca tagctattgc agtaaccttt tttgcattat
    35701 ttaactcata agctttctgt actgcttttt cagtatagtg ttgaattact tcatctatag
    35761 acaacacaag accattacct tgtacaggct cataatattt ttccattcct tgtggtattt
    35821 ctcttcctga agcatcagta cttactataa gttttccagg ctttcctttt aactttttat
    35881 catattgcat ttctacacca gatatacctg ttgcatctga agaagtatgt cctaacacat
    35941 atggtgcaaa attcccatat gggtaatatc tttgattatc ttctgccacc catattccac
    36001 ttaatttagc atctcttatt tgacttgcct tatcatcatc tatccatctt tttactttta
    36061 caagagccat attttttttg cttattaaag cgtaaatatc tttataatct tcatccaaaa
    36121 tctcagctac cttttcggct gcttcttttt tatcttctac ttccacaggt ttacaccaaa
    36181 cagtatactt agttacactt actgctaact ctttcatatt tctatcatat atagttcctc
    36241 ttttgggttc tattggtata tctcttgttt gttgttctag tgcttttgta ctcaaccaat
    36301 ttcccttcat aagttgtaga tacccagtcc taataacaag gcaaaaaaac aatgcacatg
    36361 ctagaataag aacgagtacc agccttttct tacttatcct ctttactttt ctcaaatcta
    36421 ttccccctag ttatccacat ctatatactt tatttgtcca tcttttggat agtccatatt
    36481 gagcaattcc ttagccttta gctcaatttc ttttattgat gttttttcag tttcttttgc
    36541 ctttagttcc tctaatacta tctctttttt tcttaaatct ttttgtaaat aatagatatc
    36601 gtacttcatt tccgagattt ttgaataacc acatagattc aatattatta ctgaaaaagt
    36661 tgcaatcagt aaaatgcatt tagctcctat ttttttctta tttctctttt tataattatt
    36721 ctttttttta tttttatatt catttagatt atgtatttta taattttttt tcaaattctc
    36781 accccgatag tatatagttt aaattttcct ctatactata tttgttatta atcatatttc
    36841 ttcctctaaa atttcatcgc taaattaata cactattaca caatctaatt gtattttttt
    36901 ctatacacaa caaaaaccta taaattcact tatactttta tatgaatcta taggttagat
    36961 attaatttct atttattttt atcacttcta gtatttttag ataatttctt ccataaatat
    37021 aatatgtaac taactatcta ctctctgatt cctaagttct ccattatatt acttaatacc
    37081 atctatatct atatttttat atctaaattt tcattatata tctcaataac aaagaacatt
    37141 tcttatagtg ttaattgttt tttaattgct ttaccagtgc aacaaaatat ataatacttt
    37201 ttaattaatt ataataatct tatatataag attattcttt agccttataa ctacttatat
    37261 tttttctgct actcttagct tagcacttct tgaacgtgga tttacttcta tttcttcctc
    37321 actaggtaat ataggttttc tagttattat tttcacctca gattctttat cacattggca
    37381 tataggtaaa tgctgtggac atatacaatc tgatgctaaa tgcttaaatg catttttcac
    37441 tattctatct tctaatgaat ggaatgttat tatacatatt cttccacctt cattcattat
    37501 agaagaagca tcatttatca tctttgtaat tactccaagt tcattattta cttctattcg
    37561 tattgcctga aaagttcttt tagctgggtg aggtccatct attctggctt tcttagggat
    37621 agctttttta attacatcta ctaattctcc tgtagtttct attggtttgt ttgctctttc
    37681 ttcaactata aatttagcta tacgcttagc ccagttatct tctccataat cttttattat
    37741 cttagttaat tcatcttctg tataagtatt tacaacatca tatgcagaaa actcacacct
    37801 aacatccatt ctcatatcaa gtggtgcatc ttgcatataa gaaaatcctc tatcagcttc
    37861 atcaagttga tgagatgaaa ctcctaaatc agctaataca ccatcaattt tgtaaactcc
    37921 tattttttct aattcctctt ttatattttc aaaattgctg tgaacaaact tcactctact
    37981 ttcatattca ctcaatctct cttttgctgt gcttatagca tttttatctt ggtcaaaccc
    38041 tataaataat cccttatctg acagtttttt tactatttct ttagaatgtc ctgctcctcc
    38101 catagtacag tcaacataca cgccatctgg ctttatattt aaattctcta tacactcatt
    38161 taaaagaact gatacatgat gaaattccat agttacctcc cttaaattca ctttttaaac
    38221 tattcttcac taatattatt tttatttttc tttgataaat aaacatgtgc aattatgcca
    38281 ccaataactc caattagact tataacttgt gccattctaa gtggtcctaa cattaaacta
    38341 tctgttctta atccctctat aaaaaatctt cctattgaat ataaagttat ataagtaact
    38401 ataacttgac cttcatattt tttatttttt ctaaatagta ataaaactat aaatattcca
    38461 aaatcccata tagactcata taaaaaagtt ggatgtacct ttactccatc aaccattatt
    38521 ccccaaggta aattggtagc acctccatgt gcttctccat taataaaatt tccccatctt
    38581 ccaatagctt gtgctaaagg cattccaagt ataactgtat cagccatttt taagaagtta
    38641 atatttttaa tcttagtgta tatataacca gctaatattc caccaattaa ccctccatgt
    38701 atagcaagtc caccacctct aaaattaaaa atttgagaca tattttgagc atagtaactc
    38761 caattaaata caacataata gattcttgca cagattagtc caactggaat tgctattata
    38821 gctatattta atacatcatc ttctttaatt cccactcttt ttgcttcttt tattgctatt
    38881 aaagttccta aaatcattcc acatgccata agtattccat accacatgat gtctatgcca
    38941 aacagtgtaa atgctactct atccataacg tcacctcttt gtattaattg aaaatatttc
    39001 caaagcaata tgctataatt acaattaatt gtaattatac taaattatga taacacatta
    39061 atgttaattc tacaaaaaat attaaaattt attctacaac tccctacact atattatatc
    39121 taattactat aaaatttttt aaactaaatc tctcatgact aaagttacaa gtgtacatag
    39181 atatttttta atcaaaaaga ttgatgcata tatacatcaa cctcttctaa ttcttatcta
    39241 tagctcttaa atttttacct caatttatat aaatatattt tataaatttg ttttaccaaa
    39301 ataaacattt aaaaacataa actaatactt aattagttat tcttattatg attaagtttc
    39361 tatttaggct ctacaataga aataacacaa tactcttctt taaaatgctc ttttaatctt
    39421 tcttcaactt cctcaaaagt aatatcttta ataatatcta aataatccaa tagatttata
    39481 tccttaaaaa cataagatat aaaactatta cctataaagt ttatagaatc aaagcactta
    39541 ataaatgacc ctattttttt ctttttagtt ctctcaaact cttcttttga taatccttct
    39601 ttttttgatt tttctatata atcaagaatt atttctttta cttttttagg ctctttagaa
    39661 tctccagcta ttatgctaaa agcataatcc acttgagacg aaaatccagc tccaaaattt
    39721 tcatttatta aaccttgcat atacaaatct tcataaagct tacttccttt tttaaataac
    39781 atccctacaa gtatatcagt tacaatctct ttacgtaaaa gttctttccc ttttaaacca
    39841 acattgctat ctttaaaacc tatgttgaac ataggcatag atatagggaa tttttctata
    39901 acctcttttt cttttacact ttctggttct tctggataaa atctttctat actcttagag
    39961 agtctgtcta ctttgtaatt gtttgacttt ttagttacat ctataacttt ttctacatct
    40021 aagtcaccaa caacaaataa agccatattt cctggattat agaaagtatt ataacattta
    40081 tatagctctt ccttagttat cttatatata ctatcaacag tacctgctat atcaattcta
    40141 gcaggataat ttacatacat tgccttcaag caattaaagt atacattcca atcagggtca
    40201 tcattgtaca tttttatctc ttgtgctatt ataccttttt ccttttcaac attttcatct
    40261 gtaaaataag gtgtttgaac atagtcaatt agatgttcta aactctcata aaaattttca
    40321 gtagcagaaa ataagtaggc tgtcattgta aaattagtaa atgcatttgc atttactcct
    40381 aattttgaaa atttatcaaa tgcatctcct ccatcaggtt gctcaaacat cttatgctct
    40441 agaaaatgtg caataccttc attcactcta attttcttat cttctccaat tggtacaaat
    40501 tctaagtcat ttgaaccata attagtagcc aaaatagcat actttttcat aaaacccctt
    40561 ttaggcataa aatatacatc taatccattt tgcaatttct cataataaac ttcttctttc
    40621 aatatatcat taactatttt ttccatagac atctcctcca ttaatttctc aagaagtata
    40681 cagtatcaag ctctatattt tttatagctt caactatatc tttttttgta accttttcta
    40741 tactagatat tatgtcttgt acttcagaat ttgtctttgc catagactga gagaaaacaa
    40801 aatcagacat accacctata ttatcagtta tagatttcat agaattaact aaagcaagtt
    40861 tactgttttc taattcttca tcagatatat cacctgcttt tacactttct acttgttttt
    40921 ttatcaattc tacagcttta tcataatctt tagtttctat accagatgat ataaacatga
    40981 tacttttata cttctctatt gaagagaata tatagtaaca taaactttct ttttctctta
    41041 cattaacaaa taatttagag tgtggaccac cacctaagac attgctccca actactaaag
    41101 cataatattt atctatgtct gcataatcca catttgctct ataacccata actaacttac
    41161 cttgagttat ttccatttgt tcatctataa cttttacctc atccacattt tttataaaat
    41221 ctgctcttgg tatatttata atttcttctc tttcaaattt tagattttta cttattatat
    41281 ctacaacttt atcttcatca aaattacctt ctacaactat atctataggt gatgttttaa
    41341 gtatgttttt ataatgttca tataactctc ttgaagttat actatctatt tcatcttcat
    41401 aaccaaattc acttacacta tatctctctc ctttacacat agcctcaata catttatctt
    41461 gcgcatattc ctttttatca tttattattg attgtatctt ttctcttaaa ttctcttttt
    41521 caatatttaa atattcttct ttaaacccac catctacaac aagcgtatta tttattactt
    41581 cattaaaaaa ttctactact tcttcaaata tactctcatc taaatacttt tcacttatgt
    41641 taattacttt aaaactcaat acttgacgtt ctccacgttt tacagcatca gctcccatag
    41701 atgaaccata taaatcatct aatttattgg atattgctct agcactagga tatttagcgc
    41761 ttccacttgc tattattgat ggtattagag cattttttgt agtttctttt tcatccaata
    41821 gtctctgaac atataaactt ataagattcg atttaaactt ttctgttttt atcaaagtaa
    41881 gattaatatt attacctaaa tttattattt ttttagtatt aaccatatgt acctcctatt
    41941 tttatttaaa catcaatttt aaaattgaaa tttatttatt ttttaattac atatactcac
    42001 atataaaaac cttctattta attatatcct ttttattatt ttctaaaagc aatattttta
    42061 tttaaattaa atacaaatat tatttaaatc aatatgcttt aaagtctagt ttacaagctt
    42121 gatatatatg atgtataatc aatatgtatg tctataatta aaacaatttt gcaatcctat
    42181 agattgattg tttaaagtta tataaagaat ataaaaaaga ataagagaga ggacgattaa
    42241 tatgaaatta ggtatagttg gtttaccaaa tgtaggtaaa agcacactat ttaacgcaat
    42301 aactcaagca ggtgcagaat ctgcaaatta ccctttttgt acaatagacc caaatgtggg
    42361 agttgtatct gttccagatg aaagattaaa caaactacaa gaattatata attctgaaaa
    42421 aatagttcct actgctatag aattttgtga tatagcaggt ttagttagag gagcttctaa
    42481 aggagaaggt ttaggaaata aattcttatc acatataaga gaagttgatg caatagttca
    42541 tgttgttaga tgttttgagg atgaaaatgt tgtacatgta gatggttctg tagacccact
    42601 tcgtgatata gaaactataa acttagaatt aattttctca gatatagaga ttcttgaaag
    42661 aagaattaat aaaactcaaa aagctgctaa ggctgataaa actttaggtt ctgaacttga
    42721 tttattaaaa tcaataatgt ctactttaga agaaagtaaa tgtgtaagaa ctatggaatt
    42781 tacagaagat gaacaaacat tcgtaaattc attggattta cttacatcta agcctgtaat
    42841 atatgcttca aatgtatcag aagatgattt agctgataat ggagaaaata ataaatatgt
    42901 tcaacaagtt aaagcatttg cagaaacaga agatgccgaa gttgttgtag tatgtgcaca
    42961 aatagaagca gaaatttctg aacttgattc tgctgaagaa aagaaagagt ttttagaaac
    43021 attaggtctt gaacaatcag ggcttgataa gcttataaaa tcttcttatg ctttacttgg
    43081 tttaatttca ttcttaactg ctggtccaaa agaagttaga gcatggacta taaaagttgg
    43141 aagtaaagct cctcaggcag gaggaaaaat acattctgat atagaaagag gatttatcag
    43201 agcagaaaca atagccttta atgatttggt tgagcatggt actatggctg ctgctaaaga
    43261 aaaagggttg gttaaattag aaggtaaaga atacatagtt aaagatggag atgtaatatt
    43321 atttagattt aatgtttaaa atgattaatc gtatacactt tgactattat atataataac
    43381 taaaaaacta agattataat aatacaatat tatcttataa taattatata gaatttaaaa
    43441 ataaaagaag agtatttcaa atgatttgta taaattatta tgaaaaactc tttttttgat
    43501 ataataaaat tacttacata tataatattt aaatttataa attatatttt tattttttaa
    43561 aatatgtata acacacctat agaaattact attattacta tctaaagtat tttgctataa
    43621 tcccatatac tcttacctca aaaacattca aatgtaaaaa atactacata ttaataaact
    43681 ttgcccaata attcctaaaa taatatccta acaatgattt atgtttttat aatagtatat
    43741 ttttacataa aaaagtgaac attgattaac aaagttcact tttttataaa tttttatgtt
    43801 ataattcaca attttattta atttgtttct tttctattta aactatatct atctaatatt
    43861 aatttttcat attcttctat tggcattggt ctagcaaata aaaatccttg ggccatatca
    43921 caacctataa accttaaaaa ctctgcttgc tctacagttt caacaccttc tgaaacaact
    43981 tttatatcaa gttgctttgc catttgaaca atacttgaaa ctacaatttg actctttttt
    44041 gcatttccca ctgttataaa gaattgccta tctaatttca atacatcaat tggcatatct
    44101 ttaagcatat ttaaagaaga ataaccagaa ccaaaatcat ccatagaaat tttaaatcca
    44161 acagatttca aagtttgcat tattttaaat aatatttttg tattgtcaaa tattgcactt
    44221 tctgtcaatt caatctcaat taaatttggt tcaatttcat attcttttgt tattctttca
    44281 agctcagaaa taaagcctgg attctcaaga tgtactcttg ataagtttat tgatatagga
    44341 aatgtgggga aattttcatt ttcccaacgt ttaaaatttt tacaaacttg ggtaaataca
    44401 aacatatcca attctgttat aaaaccattt ttctcaaaaa taggaataaa tacacctgga
    44461 cttattagac cttttttggg atgttgccaa cgtacaagtg cttcagcacc tacaatttta
    44521 gtagttgata aatcaacctt aggctgtaaa taaactttaa attgttcatt ttttaaagca
    44581 tcatgcattt cttgttcaat atcacgttct tctatgagag tttcttttaa attttcagca
    44641 taaatctcat aaacttttaa atattttctt tttactgtag tttttgcaat catagctttg
    44701 tcaagacagg tagaaatatt tgtttctccc tcttcaacaa aatatacacc tatggatgga
    44761 attaaattga gttctactcc caaacttgtt tttatcattg acaatttttt acgtataagt
    44821 tcacatattt ctataattga ctctctatta tttttctttt caaatattat agcaaaattg
    44881 tcatttgaaa ttcttgaaaa tacagattgc tctttaaata tattcttaat tatctctgct
    44941 atttccttta atactctatc tccttcttca tacccaaacc tatcatttac tagcttaaac
    45001 ttatctatat caaaataaat taaaactaga ttctttttct catgagagga taaaaatttt
    45061 cccccttcaa gattaaattt atttgaattg ccaatacctg taacgttatc tttaaaagca
    45121 aattcttcca atttttcctt actcttttta tgtataaata gtatataaat tgttaatgcc
    45181 gtaaagatta taatcaagac tacacatgct gataatgtaa gttttataat agcatatgat
    45241 ttctcagata tagcagtttt aggaacttca gaaaaaagat accaatcatt gattcctatt
    45301 ggggcataac ttaaataata tccttttcca aacatactat aacttaatga acctgattta
    45361 aagtttttta tatttgactt catattgttg atactagatt ttgatattga atcacttctg
    45421 ccaatgtaag aaaataaatt ttctttagta gagttggcgt ttttactgct tggatttaaa
    45481 acaatatcac cattacttct agttatataa gaatatcctt ttccattaaa tgtaggtaca
    45541 gaaagtattt tttcatacaa cttcgtacta tgtgtggcaa atataactcc tttaacctca
    45601 ttatctttat aaattggtac agaatataca ttaatattac tattggtatt tttatcatct
    45661 tctattacat cttttaattt tcctgttata accacttctc cttgcattga ttttaagaaa
    45721 taatctcttt tagagaagtc ttctatataa ccatctgtag tgtatgctgt accatttggt
    45781 aaaataactc ccattctttt aaatgaacta ttaatagctt gtctttttag tatagaaagg
    45841 atattatcta cttcaaaaga ctcttctcct tcaataaata ttgaaattga ctctagtaac
    45901 tttatatctc cattaatttg tttttttaac acattgacgc tttgatttgc tatttctgaa
    45961 agatattgat tcgtttcttc acctaatgtc ttattcaacc ttgaaccata aatcaaacag
    46021 gaaattgtaa ttactaagat acttatgaca gcaattatgg acaaaccata cctattattt
    46081 tttgcatcac ttaacattat gcttcctgcc tttctcgaat ctatgtatgt ataatcatta
    46141 tcttatgaca attattgtaa acattttata ataatactta tttttccata tttactgtaa
    46201 ttatacaaaa ttataaactt tattacaaca ataaattaat taatatagat attagtgttt
    46261 acattattgc attatctatt ttacaattat ttacatataa aaaaatgtaa tatcaaagtg
    46321 aagcttgata ttacattttt gttcttgtat tttgtttaat ttttatgcta catcttactt
    46381 aaacactcat ttgcaacttc tttatcatca aaatgatgct taactttacc tataatttga
    46441 taagtttcat gtcccttacc tgttataatt acaacatcat ccttttttgc catacttata
    46501 gcttctgcta tagcttgttc tctatcaaca acaacatggt aattttcttt tttcttgtca
    46561 attccttcaa gtatatcttt tattattgcc tctggttctt cagttcttgg attatcagaa
    46621 gttataatac ataaatcaga atatttttgt ccaattgctc ccatcaaagg tctcttttca
    46681 gtatctctat ctccaccaca cccaaacaca gaaattattt ttccttctgc aaattgttga
    46741 gttgtcttta gtacattttc aagtgcgtca ggagtatgag catagtctac aattacgctt
    46801 atacctttat catttggaac tgtttcaaac cttcctgata ctccattaga aagtctaagg
    46861 ccttctttat atattggttt aggtatgcca agtacatagc aagcagctat aactgctaaa
    46921 gtattatata ctgtaaacat ccctggaact ggtataaata ttacttcttc atatgaaggt
    46981 gttattaatc tataagatac tccatccgaa tctgatttta tatctctagc cataaaatca
    47041 gccttagtat caacaccata agtgtaacaa ggtacattta taccttttat attttcatat
    47101 atcttttttc caccttcatc atctatgttt attatatttg ccatagtagt cttaaaaaat
    47161 aatttttctt ttgcttttct ataatcctct aaatctttat gaaaatctaa atggtctggt
    47221 gttaaatttg taaatatgcc tagtttaaag tctgtttcat caactctatt taatgccaat
    47281 gaatgtgatg aaacttccat tgcacagtag tcacatccat tatccaacat attattaaaa
    47341 tgatattgta aatctatact ttctggagtt gttgaattgg aaacaatgtc tttttctcca
    47401 tcaaaaattt ttatagttcc tataagtcca actttattct tatttaaagt taatatctca
    47461 tttagtatag tagttatact agtttttcca ttagtacctg taactcctat aacgttaaat
    47521 ttttgagatg gatgattgta aaaattatca gctacttttg ccatatcttt tcttgtatct
    47581 tttaccttta taaatgtaca tccttttatt gctacatctt cttcaacaag aaatgcactt
    47641 gctccctttt ctatggcatc ttttatatac ttatgaccat ctgacacaaa tccttttata
    47701 catataaata atgtaccttt tgtaaccttt cttgaatcat attgtacatt attaatatct
    47761 atatttaatt cacccttgac attgattata tccaacccct gtataatatc atttaatttc
    47821 ataaatgctt tcctcccttt aaactctttc tgctaaaatt acactacata taatattata
    47881 ttaagaattt tttactatgt gaatggttaa aaatgcttga aacattgcaa aaaatgctct
    47941 ataattttct ataatataac tgaggaaagg tcttctataa aaactatgga taataaaatc
    48001 gggtacttaa acgataactt taaaatattt aatattagag ataaaaaaga tatacaattt
    48061 gaataccata atcatgattt taataagata attatattta taaatggaaa tgtaacttat
    48121 tttgttgatg gtattcccta taaactaaag ccttgggata tactctttat cagcaataat
    48181 gaaatccata aaccagttat agattcaaat gtcttttatg agagaattgc aatatggatt
    48241 agcccagaat ttatgaaaaa aaatagtgat gctagtagtg acttagaaaa atgttttaaa
    48301 atagctacag agaataaatg caatagattg cgtttaaata tgcatgatat tgaatctatt
    48361 aagagtttta ttgagcaaat aaatatttcc gaatccaata ctgaatttgg aaatgaaata
    48421 ttgagaaata cattatttat acaacttatg atattcttaa acagaatttt cctaaaaaat
    48481 gaaaatatgg aatcaacaga agatgttttt tatgatgaaa ctattaagaa agtattaaac
    48541 tatataaatt caaatataga tgataagctt tcaatagata gcatatcgtc tgaatttttt
    48601 ataagtaagt attatcttat gagaaaattt aaatctcata ctggaacgtc tatacacaat
    48661 tatatagttc aaaaaagatt aattttggca aagtcactaa taaccaatgg tcaccttatg
    48721 agtgaagttt gtaataaatg tggattcaac gattattcta gttttgtaag ggcatttaaa
    48781 aaaaactacg gtgtatctcc taaaaattat ataaacaata aaaatccttt agatattact
    48841 cttttagatg aatagataat ttatgtaaat tttattttaa taaaacttga agtattagtg
    48901 tatttatctt actaatacct caagtttttt aatgttttaa aatatatcaa aatataatga
    48961 tatatatttc tattacttaa aatatatatt aaataaattg catgttaact gaacctattt
    49021 atatatttat taaatctcac ataactttta gttacactat catatagcta tcctattttt
    49081 tcaatatcat ctcttaatat acttactcta ttctcctctt ttgctgtggt tactcctttt
    49141 ttaatgctta atttctgatt ttgttctaaa ttcgtaaata ctacaggact tattgttgat
    49201 agaccatttt tttcaatata ttctaagtcc attttaacta atttttctcc cgcttttact
    49261 tcatctccta cattcacaaa tacttcaaat ccatttcctt ctaagtttac agtttctatc
    49321 cctaaatgta taagtatttc tactccactt ttttgggatt ttattattat tgcatgctta
    49381 gttggaaata taactccaat agttccatca actggtgaat aaatcaatcc atcactagat
    49441 ttaattgcaa atccatcccc catcagttta cttgaaaata cagaatctgg cacttcttct
    49501 atatctaata actctccatt tgttaatgaa tcaatctttt ctactaaagt attttccata
    49561 tttgcaactt ccatattttt tttcacttta tttttatcaa catttttagt aacagtactt
    49621 tcaacctttg tttttccctc tattatatct tttatatcag actttattga atctgatttt
    49681 ggtccaaata tagcttgaac attgttgcca ataaccataa cacctgctgc tccaagtgat
    49741 ttcaattttt ctttatctac tttatttata tcatttacaa ccaatctaag tcttgttata
    49801 cacgcatcta gactctttaa gttgtcttta tttcctaaag caatcaaaat ctctgatgct
    49861 aattcattct tagacatttc aatgacttca gcgttagttt ctgactcatc ttctcttcct
    49921 ggtgtcttta aattaaattt tcttatcata aatctaaata cactatagta taatactgca
    49981 aaaccaatac ctaccaagat agccaagtac catggagttc tattaggaag aacaccaaat
    50041 aataagaaat ctattaatcc tcctgaaaat gtgaatccaa ttttaactcc taataattgc
    50101 ataattgcgt atgataaacc tgaaaataaa caatgtattg caaataatac tggtgcaaca
    50161 aataaaaacg caaactctat tggctcggtt attcctgtta aaaaagaggt taatgctgct
    50221 gatgccatta tacctgctac aaattttttc ttttctggct ttgcttcatg caccatagca
    50281 agagctgctg ctggaagacc aaacatcata aatggaaatg cacctgtcat aaaagtacct
    50341 gctgtgaaat ttactccatc tttaagttga gcaaagaata tcttttggtc acccattaca
    50401 agctcaccag ctttatttac atattctcca aattgatacc aaaatggatt atggaaaaca
    50461 tgatgcaaac caaatggtat taatagtctt tccaaagaac cttccataaa tgctgctagt
    50521 gtttgatttg cttctataac attttttgag aaactaagta atccctcttg tattggaggc
    50581 caaataaaag acaatataat tcctattgct atagcaacta atgaagtaac gattggtaca
    50641 aatcttttac ctgcaaaaaa acctagatac tgaggtaatt caattttata aaacttttta
    50701 taaagataag cagccactat ccctataata ataccaccaa atacccctgt ttgaattgtt
    50761 ggtattccaa caatatttgc atacatagaa ttgtctacca tatcttctgt aacacctgcc
    50821 ataacaccca tagatgtatt gagaattaaa aaacctacta tggctgccaa tgctgcaaca
    50881 ccttctcctt cagttaaacc aacagctacc ccaactgcaa atataagtgg taagttatta
    50941 aatataattt gacctgaact ttccattata cttattataa gttgaaatgt aggattcgcc
    51001 aaagctggaa aatgagccaa caatgcgtct cctgctaaag cattactcac gccaagtaat
    51061 atacctgctg caggaagtaa tgcaactggt agcattagag attttcctac tttttgtaaa
    51121 acaccaaata cttttttcat ttacttttct ctccttatta ttttatattt ttttaaataa
    51181 aaaagactta agtttataaa aagttacatt agtatactta attctaaaat taaacttatg
    51241 ttaatataaa caaacctata ttaacctaat ttcagaatta aaaataaact attataattt
    51301 ttttataaac ataagtcttg cctgcattat cagtaacaat cttaatgttt taaaattatt
    51361 attttatatt aaattttaaa taatatatta aaattaaaca taatatatta aatctataca
    51421 ttctgtatta aactactctt tattataaat tcagtacaga tataactctt ttgatatgta
    51481 atgttaaata aagtagttca tcttgactta catagtaatc ataattcttt tctacatgag
    51541 tttttatttt atatgcacaa tcataatcct tttcatactt tactttaatt atatctataa
    51601 tttcattatt tgtatcattg attttttctt tttttactaa tcgttttgca aagaatttta
    51661 aatgagtcag aagcctatca taatttatat catcttcttt aaattcaact ctataataat
    51721 atcttataat atttagtatg tcttttacaa ttttagtaat taacagtgat tcctttgaac
    51781 ttcccttata gtttgaattt actatatgca ttgctataaa accagcttca tctactggaa
    51841 atttcacatc aaattcttta tttatataat ctacagccca tttcccaatc tcatattctt
    51901 ttttatgtat tctttttatc tcatgtagta aatcattctt tatagttatg ttttcatgat
    51961 atcttttaat tgcaaatgca atatggtcag taagtgctac ataaatatat tcataaagtt
    52021 tagtattcaa attctcctct gcataagcaa ttatttcagt actaacctca aaaaatttct
    52081 catcaacctg gcttgctagt ttactaattt tatctaaaaa gctttcatct tgtattacaa
    52141 aagttctttc aattttactt ttatctattt cttgaccttt ctttttttga aacccaattc
    52201 cacatcctgt taatattaat tcttttttta tattttcatc taaaactaat acaacattat
    52261 tattataaat ttgttgaata atcataatca atatctctcc caaaatacaa tttcccttat
    52321 tcataaaaaa atacctaaat taagatacaa ttcacctgta taccttaacc taggtattgc
    52381 ctgcttacca gtaacaatcc agcttgttaa cgcttatata ttgtattcaa tttatggttt
    52441 tattctatta taaataaata tatatgtcaa gtaaattatt gaaaactatt tcctattttt
    52501 tagtattaat tttaacatca aaaatcaaat tttattccat tatatttatg attctatcat
    52561 catcatttca tcatagagaa tattttccaa taactcttta gccacttctc ttgatatttg
    52621 cttagtttca actaattgtt gaacactgtc tctttgactt tgtatcgcca ttactctgta
    52681 gtattctact cttgcctcaa acttatcatc attttgaatc tttctagtaa tccaattcaa
    52741 ataacgatta tagaatctga ttgctattaa ggcctcatgt ctgttatctt catcagtatt
    52801 tttatttata aatgatatag cagttttagt agaaagtgca tatgcatggt gaaactcttt
    52861 gattatttct ttattctcag atactatttt tgtaattttt tcttttactt ctttctttac
    52921 ttttctattt ataatccaca tgcttatttt taattttaca attttaaata tagatttttg
    52981 aacagatttt cttgattttg taatataaaa tctatacaat ttaaaggctc tatcagaaat
    53041 tttaccatct tctaatagtt tcaaaacagc taataatccc tgttggtctg cttctgcaat
    53101 catcatactt ataagtttat tatctggagt atttagtatt cctttttctg agtctaccaa
    53161 ctgttcattt aaatcatgta taactggttg tacttcttgt gctttttcat tactaagttt
    53221 taaaatggct tctttcaaaa ttagtttata tgcctcttta tcagataata aaggttctga
    53281 ctcttgtacg ttatttttta ataatcttgg cagtaaaact gttgccaata ctaaacttat
    53341 aagaataact tctgatgata taaataaaac agtatctctc attggaaata catctttatc
    53401 agccaaataa aaaggtatag ataaggcagt tgctagtgta aatgtaccat gaacaccaca
    53461 agtagcaact attagtgagt atttacattt agaaatactc tcttttacaa cttcttcatc
    53521 cttaaaacct aaaaaaccta caaaaaaatt atttaaagga ttctttttag gttttataaa
    53581 agaattatgc cataaatata cccatataaa tcttataaca aataaaataa gtacaattaa
    53641 agtagaaata aaagtcaatt ccaatgccat attttcattt ttactactaa gtcctgtata
    53701 tatacttggt aacaaaaaac caagcagtgt aaagacaaat ccattcaata catactccaa
    53761 aacataccaa gtattgtctg atattatcct taatttagta gttgtatttt gtaaatgctc
    53821 tttttcaatt ccatgagcta tccctgccat tacaacagct aggattccag atactcctat
    53881 ttcttctgct acaaaatata caaaaagtgg agtcattatt tgtataacta ttaccattgg
    53941 aatttcttcc aaattccact tgtgtaaact aagtcttatt tttataatta tgtatcctaa
    54001 aatacttcct actattattc ctccaaaagc tgtaatcata aattgaatcc ctgcctcttc
    54061 tattgaaaaa actcctgtaa ctgtggcaag tactgcaacc ttaaatgcta ctactccagc
    54121 agcatcattt aataaagatt caccttcaag tatactcatc atatttttag gaaaatttaa
    54181 tccttgtgta attgatttta ctgctactaa atcagttgga gatattactg ctgccaaagc
    54241 aaatgaaaca gataatggca tcccaggaat aagaaaatgt ataaagattc cacctgcaaa
    54301 cacggttatt aaaactaaac caaatgcaag aagcaaaatt ggttttctga gctctaatag
    54361 ctcttttctc gatacatttt gtccttcact gaatagtaat ggagctatga tacatattac
    54421 aaatatttct ggattaaatg aaaatgagaa tttaaatggc aaaatagaca atataatccc
    54481 tagtacaatt tgatatattg caagaggaat attactccac tttttgctaa atacagttga
    54541 aatcgttgta caaaccaata atcccaacaa tgttactaaa attgacataa ctacctctct
    54601 tttcaataat aatattatag attaaactta tatatcaact aacttaatat taacagcatg
    54661 aaatcccatc ttaatcaaaa aaattttcag tttattctat tattcttatt atatacatca
    54721 aatttaattt ttgaaatatc tatactagat gacatgcaac aaaatgattt cttgatattt
    54781 cttttaaaac tggaatctct tttttgcata tttccttaca ataagggcat cttgtatgaa
    54841 acttacatcc acttggtgga tttgttggag atggtatgtc tccttttaat ataattctat
    54901 ttttcttaat tgtagggtct tgtattggta ctgcgctcat aagcgctttt gtatatggat
    54961 gttgagaatg taagtaaagt tctcctttag ttgcaatttc tattatagaa cctagataca
    55021 taacacaaac tctatgtgca atatgattta ctacactcaa atcatgagat ataaataaat
    55081 atgaaagttt atatttatcc tgtaaatcca taagtaaatt tataatttga gattgaatag
    55141 aaacatctag tgcagaaaca ggttcatcac aaactataaa ttctggattt aatgctaatg
    55201 ctcttgctat acctattctc tgtctttgac ctccagaaaa ctcacctggt tttctattta
    55261 aatggtactt agaaagacca caactttcta caacatttaa tatattatct tttatttcat
    55321 tctttggcac taaattatgt tctataactg cctcggatat tatttgttcc acatttaatc
    55381 ttggatttaa tgaactatat gggtcttgaa atatcatttg cattttgggt cttaactttc
    55441 taagttcttc cttctctaac ttatatatat ctacaccatt aaattcaact ttaccttcag
    55501 ttttttcaat taatctaaga atggttcttc ctgcagttga ttttccacat cccgattctc
    55561 caactatagc caaagtttct ccttttttta aatcaaaaga aattccatct actgccttta
    55621 cacatttaat ttccttatca aataatccag atttaacttc aaagtacttt ttaagacctt
    55681 ctacttttaa taaactctct tcttttttca attatatctc ctccttttta tataaccaac
    55741 atgcaatact atgaccacta ttcaattcta ttaaaggagg tatctgagtt ctacatttat
    55801 cacatacttt ttcacatcta tcactaaaat aacatgaatc tggcatccca attggatttg
    55861 gtacttgtcc tggaatcgaa tacaatcttt tatctttgtt ttttccaaga gcaggctttg
    55921 attttagaag tccaatagta taaggatgtt ttggattttt aaataattca acaacctctg
    55981 ccacttctat aattttgcca gcatacatca ctaatacttt gtcacacatt tctgcaacta
    56041 ctcccaaatc atgtgtaatc atcattatag atgtgtttaa tttttctttt atatttttca
    56101 ttatatctaa aatctgagct tgaatagtaa catctaaagc tgttgttggt tcatcagcta
    56161 taagtaattt tggattacat gataaagcca tagctatcat tattcgttgt ctcattccac
    56221 ctgataattc atgtggatat gaattatata tttcttcagc tcttggtatt tctaccagtt
    56281 ttatcatatc gattaccttt ttcttagctt cttcctttga taaatcttga tgtatcataa
    56341 taccttcaat gatttgactt ccaatagtaa acgctgggtt taaagatgtc attggttctt
    56401 gaaaaatcat tgatatctca ttccctctta ttcccataag ttcatcttca ttcatcttta
    56461 aaatatcttt gcctcgaaag attatttctc caccttctat ttttgatgtt ggaagtaact
    56521 tcatcaaaga catggctgtt acagacttac cacatcctga ttctccaact attccaatag
    56581 tttcaccttc atttatatta aaacttactt catttacact ctttacaatc cctttatctg
    56641 tatgaaaata aacttttaaa tctttaacct caattagtgc tttactcatt attttctcct
    56701 ctcagcaaaa ttacttaaga taacatacac cttttgattg tattttataa aaatttaaat
    56761 tacaacattt tcttacattt tattattttt ttctattaat tataataata taatagttaa
    56821 tttctatata tattgattta ataatgatta ctattataca ataaaaaata tgtgttaaat
    56881 attattttat ggaggtttta taagaatatg aaatttaaaa aattggcatc attaatctta
    56941 gtttcatcat taatgcttac atttacagcc tgtgcttcca atgataaaga caagtctagt
    57001 ggaagcaaat ctggtggaac tgttgtaata cctatggcaa gtgacccaga tataatcaat
    57061 ggagcttttg caaacgttaa agaagactct cttgcatcaa atatagttta tgctcctctt
    57121 tatacttatg aaaaaggaaa tttagtaaat tatttagcag aaaaagtaga ttttaaagat
    57181 agtaaggaat taactataaa attaaaatcc aatttaaaat ggcatgatgg aaagccaata
    57241 actgctgaag atgtcttatt tacatttaat acagttttag acgaaaaaca aaattcacca
    57301 tcaagacaat acttattggt gggtgagaaa ccagttaaag tagaaaaaat tgatgattta
    57361 acagttaaga ttactttacc aactgcaagt gaatctttct tatatggtat atctaaaatt
    57421 tctccaatac caaaacatgt gtttgaagga gaatcaaata tagctaagtc agaaaaaaat
    57481 aataatccag ttggttctgg tgcattcaag tttaaggaat ggaaaaaagg tgaaagcata
    57541 gtatttgaaa agaatgcaga ttattttggt ggagaatcta aggcagattc tatagcgcta
    57601 aaaataattc ctaatgaagc atctcaagaa gcagctttaa ataatggcga aatttcactt
    57661 atgaagacat ctgctgaagg atatgaaaag gcaaaatcaa actcaaattt acaaacttat
    57721 acttatagtg aagaaagatt aaactacatt gtatttaacc aaaatatatc aaacatggct
    57781 aacaaagaag taagacaagc cttatcatat gccttaaata gaaatgaaat gatagaatca
    57841 gcatatggaa aagaaggttc tgtacctgct aaatctatat tagttccaga agcagacttc
    57901 tatacagaag aaggtgttga aggatatgac caagatacaa ataaggctaa agacttattg
    57961 gataaaagtg gtgttaaaat tgataaatta aaaataggtt ataacacagg tagatttggg
    58021 cataaaaact atgccttagt agctcaacaa gagttgaaaa aaattggtat agaagctgaa
    58081 atagttcctt atgaaagtaa ggcattcttc aatatactat ttagtaatag cactgaatgt
    58141 gatatgtatg taaatggtta tgcttgggga ttagaaccaa acccatatag aggtatgttt
    58201 gaaactggtc aatattgcaa ccaaactaaa tattctaatg ctgaaataga tgctttatgg
    58261 gaaaaaggat ttactgagtt aaacaaggaa aaacgtgaag aaatatataa gcaaatacaa
    58321 caggatatat ctaaggatgc gcctatttac actatagatt atgaacaaaa tttaatggca
    58381 gctcaaaaaa atctaaaagg aataaaagat gctaaaccat ctcctgcaat attatttgaa
    58441 gattggtcta aactgtatgt agaataattg atgtaaaatt ttatattatt aattagaaaa
    58501 ggagatgtct aaaaataata ttgttttatt attttaaaac gagacatctc ttttaattag
    58561 gagaatttac ttatgttaaa attaatattg aatagagtaa aagttttaat acctatgtta
    58621 atcttaatat ctatattatc atttggactt ttagaattag ctcctggtga cccagcagat
    58681 gcatatataa atcctttaat gtcttcacag gatattgaaa atataagggt taatatgggg
    58741 cttgataaac cagcatatat aagatattta aactggttga aaaacacttt aagtggaaac
    58801 ttaggtattt cttatataaa ccatatgccc gttacagaac aaattatgga aaaaatggga
    58861 aatacattta ttcttatggg tacttctttg atattttcaa tattggtagc catacctctt
    58921 ggaatatttt tagctgtaaa taaaaattca ataactagta aagtatcatc tgtttttaat
    58981 tatataggtg tttctatacc ttctttttgg ataggtatga tactcatttc aattttttca
    59041 gttaaactta acattttccc atcaggaggt atgcatacta ttggaaatga tagtattgga
    59101 gatttagcaa aacatttagt tttgcctgta ataactttag gtctatataa tactgctatt
    59161 tttacaaatt atgtagaagc tagtgtaaat gaacaattaa aaaaacaata tgttattaca
    59221 gcaagagcaa aaggattatc agaaaaagtc atactattta aacatgtctt gaaaaattca
    59281 ctgacatcat tggttacaat cctaggcatg agtatacaaa aattagtcac tggtgcattt
    59341 gttacagaag tagttttctc ttggccaggt atgggaagat taatgattga ttcaattttt
    59401 tcaagagatt atactgtaat tatggcaata actatgttat cagcactatt tttaatttta
    59461 ggtaatttag ttgctgatat actatactta ttaattgacc ctaaaataaa atctagcaaa
    59521 ggaggattct agttgtgttt acaagtatct taaaaaaatt aaaaaaagat aaatcctttg
    59581 cttttgcatg tattactctt agcataataa tcatattaat tatagcttct tttatattaa
    59641 atatagactc taatgcaatt gatactactt ctaaacttca agaacctagc ttaaagcata
    59701 tctttggtac agacgaactt ggtagagatt acttctctag agctctttat ggtggaagga
    59761 tttcacttag tgttggtatt ttatcaatgc ttatttctgt agtatttggt actgctgtag
    59821 gtgttattag tggatatatt ggaggtaagc tagaccaatt cttgatgaga ttagtggata
    59881 tgcttatgag tataccaagt ttcttagttt tgattgtatt aaatacttat ctaacaccta
    59941 aagtttccac tattatacta attattggat tcttaagttg gatggaagtt tcaagaattg
    60001 tacgtggcga aacattaaaa ataaaggaaa atgaatactg tctagctgct aaagctactg
    60061 gtatcaaaac tagaaatata ctattaagac atatagtttt aaacttaaaa gagactattg
    60121 tagttgctgg ttcgttaaat attgctaatg ctatcttaac tgaatctgct cttagttttt
    60181 taggtcttgg aatccaattg cctcttgcat catggggtaa tatgcttcaa gatgctcaaa
    60241 gacatatttt tgacaagtta tatttagctg tatttccagg attacttata tttttaacag
    60301 tcatgagttt gactataata agcaaaaaat tttctagtaa tacttaacaa attttatata
    60361 gaaaataaaa acagtgatta tctaaagata tacactgttt ttatttttcg tttaaaaaaa
    60421 tacatatttt gtatattata actttaaata ctactctacc atgttatgca aagcgtatta
    60481 ttgctctcaa acatatagat gaaaaactaa tagtttatta taataaaaat tgatttattt
    60541 atttgttatt ttaataacat ttttaagagt tctttttact aaagaaatct ataataaatt
    60601 taaatacatg ttggtctaca tggctataac gttctttttt aggtctacat aatataactt
    60661 tccatgtaat aggatgatta aaaggctttt ctataatttt gctattttca aaaaaatcat
    60721 gaactggtga tggtaaaatt gttataaaat cagaatttgt ggttgatagc aacaaaaaat
    60781 cccatgaacc agacattata tatcttttta acttaacatt ttcatcagta aatttttgca
    60841 ttagcttatg atgtatcata aaagtaggat taaatattgc aagtaactgc tcattcaaat
    60901 cgttccaatc tatcttatcc ttcttagcaa gtggatgatt tatatttaaa aatgctgtaa
    60961 gttcatcttc ttgaagcaca tgttcagtta ctacactttt atcaatttta tgtggatgta
    61021 acaatactgc ataatctaat tcctgtaaga taagcattct atttaagtca tatgcaccct
    61081 tctctactat atcaaattct atatctggat tatttgcaac taactgtgca actacatctg
    61141 aaaatgctat tccaagtata agtggaggta ttcctattct aacttttcct ttaaattgaa
    61201 ctgaatcttc tcttaaatct tccatcatat ttttgtattc atttatgata tgttctgcat
    61261 ttacataaaa tctttctcct gctggtgtta acccatttaa cctgccttta tacctttcaa
    61321 ataaatatac atcttcactt tcttcaaaat tttttataat ttgacttaat gctggttgag
    61381 atatgtgaag tgtcttagat gctattgata aattaaaacc agatttcact atttcaacaa
    61441 aatatttcaa ctgttttata tccattttaa acccccttcc ccaaaagtat aatttagatt
    61501 atattttttc ttctaatgat attttatagg aaaatcaaca taatttcatt aatattttaa
    61561 caaaatattt ttctaaatct actataaatt tttatcctat aaatttttct tatacactat
    61621 ataaaaaatt agacttagac aaaacgcttt tttcgccgta atctataatt agaaacagga
    61681 aaacctaaag cattaggaat aaaagtaatt gaaatactta aaaacaagct tgtattaaaa
    61741 aagtacttta ttatagtgtt ccctaatttc tttattcaga aaatttttaa ttatcattca
    61801 agaaaggtaa ctattagata tgaaagatgt agtaatcgta tcagcagtca gaacacctat
    61861 aggaagtttt ggaggtgtat ttaaaaatac ttcagctgtt caacttggaa ctatcgctgt
    61921 taaagaagcg atatcacgtg taagacttaa tttatctgaa atagatgaag taataattgg
    61981 aaatgttctt caaacagggc ttggacagaa tgttgctaga caaattgcta taaatgcagg
    62041 tataccaaat tctgttccaa gctacacagt aaataaatta tgtggttcag ggcttaaaag
    62101 tgtccagcta gctgcccaat caatcacatc tggtgaaaat gatgtggtaa ttgcaggtgg
    62161 tactgaaaat atgagccaag ctccttatat cgttccaact gctcgctttg gtagtaaaat
    62221 gggtgacata accatggtag atagtatgct aacagatggc cttattgatg ctttcaatca
    62281 gtatcatatg ggaataactg cagaaaatat tgcaactaaa tttgaattta ctagagaaat
    62341 gcaagataaa ttggcattag aaagtcaaaa taaggctgag aatgctataa aaaacaaccg
    62401 ctttaaagaa gaaatcgttc cagtagatgt tttaatacgt cgaggaaaaa tagaaactat
    62461 tgataaagat gaatatccta aattaggtat gacatttgaa ggtttatcta aacttaaacc
    62521 tgcattcaaa aaagatggta ctgtaacagc tggaaatgcc tcaggtatta atgatggtgc
    62581 ggctatgtta atactaatga gccaacaaaa agcagacgaa ctaggtatta gaccacttgc
    62641 taaaataaaa tcctatgctt cagctggtgt tgaacctgaa gtcatgggta ctggtccaat
    62701 ccctgcaact agaaaagcac tgaaaaaagc tggacttagc atcaatgata tagacttaat
    62761 agaagcaaat gaagcgtttg ctgcccaagc attagctgtt aaaaatgaac ttcaaataga
    62821 ttcatcaaag ttaaatgtta atggtggtgc aatagcatta ggacatccaa taggagcaag
    62881 tggagctaga atacttgtta ccttaattta tgaaatgcaa aaacgtaaag ttgaaactgg
    62941 acttgcaaca ctttgtattg gtggtggtca aggaatatca atggtggttt cacgatagga
    63001 ggaaatatga ataaaatagt tagcattgat gaagctctat ctcatgtaaa agatggagat
    63061 acaataatgg ttggtggatt catggccaat ggttcaccag aaaatttaat tgattattta
    63121 tgtagtaaaa atataaaaga tttgacacta atttgcaatg atactggctt tattgacaaa
    63181 ggagttggca aaatggttgt aaataagcaa tttaaaaaga taattgcttc tcatgtagga
    63241 ttaaataaag aaactggaag acaaatgaat aacaatgaaa cagatgttga gttagttcct
    63301 cagggaactc ttgctgaaca aatacgtgca gctggttatg gtctaggagg tatactcaca
    63361 ccgactggta ttggtactct tgttgaggag ggaaagcaaa aaattgttgt cgatagcaaa
    63421 gaataccttc ttgaaaaacc aatttatgca gatgttgctc ttctatttgc atcaaaggtc
    63481 gataaagcag gtaatctagt ttataaaggc tctatgaaca attttaataa tttaatggca
    63541 tctgctgcca aaattacaat agttgaagca gatgaaatcg ttgaaattgg tgatattgac
    63601 ccaaatgaag ttaatacacc aggtattttt gtgaattaca tcgttgaagg aggtaattta
    63661 taatggataa attagaaatg caagaatata ttgcaaatag agtatctaaa gaattaaaag
    63721 acggagccgt tgtaaacctt ggaataggtc taccaaccaa agtagcaaat tatattccgg
    63781 ataatgtaaa cgttatctta caatctgaaa atggcttttt aggtttaggt tcagccgaag
    63841 atggaaattc aagtgatgaa actattgtaa atgcaggtgg tcaaccagtt actatacttc
    63901 ctggaggatg tttctttgat agtgctactt cttttggaat aatcagagga ggtcatgttg
    63961 atataactgt tcttggcgca cttcaggttg acaaatatgg caatatagca aactatatga
    64021 ttccaggtaa gatggttcca ggtatgggtg gagctatgga cctagtaact ggagctaaaa
    64081 aagttattgt agcaatggaa catacttcaa aaggttctgc aaaaatatta aataattgta
    64141 ctcttccact tactgcaaca aatgctgtag atttgatagt tactgaaatg ggagttatgg
    64201 aagtaacatc agatggaatt ttacttaaag aaataaatcc agctttcaca ttagatgatg
    64261 ttatttctgc tactgaagct cctttaatat tgtcagattc attaaatgga aaaatatctg
    64321 ttgtttaaaa taattaaaac tagaaaataa aaatctctta gacgtattac atataaattt
    64381 gtattgctta aaatattaat ataaaaataa aataaaattg gaggaaatga aaatggttaa
    64441 agataaagtt gtattcgtaa caggagctgc aagtggaata ggtaaacaaa tagctgaatc
    64501 gttcttaaaa aatggtgcta aagtaatgtt ctctgatata aatcaagaag ctttaaataa
    64561 taccataaca gagttacaaa aaaaaggtta tgattgcatg agtgtaaagt gtgatgtaac
    64621 taaggaagaa gaaattaacc acgctataga caaaactgtt gaaaagtatg gcagattaga
    64681 tatattaata aacaatgctg gacttcaaca tgtttctatg atagaagatt tcccaactga
    64741 taaatttgaa tttatgataa aaataatgct gacagcacct tttatagcta ctaaaaaagc
    64801 atttcctata atgaaaaaac aaggctttgg tcgtataata aatatggcct caatcaatgg
    64861 tgtaatagga tttgctggaa aggctgctta taactcagca aaacatggac ttattggact
    64921 aacaaaagtt gctgctcttg aagctgccga ttctggtata acagttaatg ctttatgccc
    64981 tggatatgta gatactccac ttgtcagagg tcagttcaat gacctttcaa aaactcgtaa
    65041 tataccattg gaaaatgtct tagaggaagt tttataccca cttgtaccac aaaaacgcct
    65101 attagatgtt caagaaattg ccgactatgc tatgttctta gcaagtgata atgctaaggg
    65161 tattacagga caagcttgct tactagatgg aggatatact gcacaatagt tattatattt
    65221 agggcttgaa gaaagtattc ttcaggtcct tctactaagg agggatattt atgagtatta
    65281 tcgcgccaat tggtataatt attggtatca tagctattat atatttttca gttaaagaaa
    65341 ttcatataac tatagctgct ccaatagcaa ctttaatagt tgttatttta aataaaatgg
    65401 atgttgtaac gtcaatgcta ggtgctgaca aaaacaatta tatgggtgca cttggaaact
    65461 atataatgag ttattttgca atattcttat taggctcaat acttgctaaa tttatggaag
    65521 aaagtggagc tactgtatca atagctgatt ttattttaaa taaatttggc tctaatcatc
    65581 cttatagagt tttagttgct atatttatag taagttttat attaacgtat ggtggtataa
    65641 gcttatttgt agttatgttt gcggtcattc cacttgcaag aactctattt aaaaaacttg
    65701 atatttcttg gaaccttatt cagataccac tttggcttgg tattgcaaca attactatga
    65761 ctataattcc tggaacacca gccattcaaa atgttatacc tattcaatat ctaaatacgt
    65821 ctcttactgc agctactata ccaagtattg taggtagtat aggttgtgct acatttggac
    65881 ttgtctatat gaaatatgct ctaaacaaaa gtattagaaa aggtgaaact tatgcaactt
    65941 acacttcaga attagaagaa gaatctttag atagagaatt accaggattt tttgcaagta
    66001 tttttcctct attagcactc gtaattatag ctataactgg aagtactttt ggttcagaat
    66061 ttatgaaaaa aaatgtaatt tacatagctt taatagttgc aattctttta tctgcttttt
    66121 tattccataa atttctatca tctaagatac agacattgag cataggtgct agtggttcta
    66181 taggtcctat atttgctaca tcttctgcag ttgcatttgg agcagtaata atggctgcac
    66241 ctggttttga tgtatttagc aaacttataa tgtcaatacc aggtagtcca cttataagtc
    66301 ttactgtttt gacttcaaca atgtcagcaa taacagggtc ctcttctggt gcattaggaa
    66361 tagtaatgcc aaactttgca gattattatt taagtactgg tctaaatcca gaattaattc
    66421 accgtgttgc tacaatagct tcaaatatac taactatagt tccacaaagt ggtgtttttc
    66481 ttacattctt aagcttatct aagttaacac ataaaactgg atttaaagaa actttcattg
    66541 tagttgcagt tggttcacta atagcagaaa ttattgtaat tacattagga ttactaatgt
    66601 attaatataa aacaagttaa aattcataat atgaaaggtg gtgtctcaaa gtgaactttt
    66661 tacttaatga gacactcttt ttatatgaaa taacatatgc ctatcattta aacaataaaa
    66721 aaggccttat ctctattttg agacagaccc tttttatttc ttaaagattt aaataattat
    66781 aatttgttgc taatacgaaa gcatctactg aataaattta accaaataaa aaaaaattta
    66841 tcataactat aaatttacgt tatggaatta ttataaaaat attattttct ctaactaagt
    66901 aattccatac tatacaggct tttaatacaa attgtcaaac acactgaaat atacctattt
    66961 attccatata tatctttttt acatatcttt acagtaaaaa aagtcttaat cttatgttag
    67021 tatagattca cgggtaaccc cctacactaa aggttacaaa tcagtaacat ttttagaatt
    67081 tttagattaa gaggtgttta atgatgagaa gaaatatacc aacaaaatta aaaactatat
    67141 tagctttagg agtgttaact ttagcaacag cttcaagtgc tgttactgca agtgcttcat
    67201 cacttgaaaa taatgtaaat ataagtaaca aaagtttagt atatagtaat actaaataca
    67261 agttttctgc aaaaccaaat tgttctgtaa aaccagaact taagcctgat aaagataact
    67321 cttgtaagga taagaatcat aatgacaaga attgcaacaa cactaataaa cctgaggaca
    67381 acaataattc agactctact aataagcctg ataacaataa acctgagtct aataaacctg
    67441 aagacaacaa taattcaggc tctactaata aacctaataa taataaacct gagtctaata
    67501 aacctgaaga caacaataat tcaggctcta ctgataaacc tgataacaat aaacctgagt
    67561 ctaataaacc tgaagacaac aataacaata attcagactc tactaacaaa cctgatgata
    67621 ataacaactc aggctctaca agtgaaagtt tttcagctta ccaaaaagaa gttgttgact
    67681 tagtaaatat agaaagagct aaagctggat taaatcctct tactcttgat tcttctatat
    67741 caaatgttgc tacaaaaaaa tctcaagata tgattgataa caactatttt tcacacaatt
    67801 ctccaactta tggttctcca tttgacatgt tgaaaaaatt tggaataagc tataagacag
    67861 caggtgaaaa tatagctatg ggtcaaaaaa ctcctaaaga agttgtaaac gcatggatga
    67921 attctgaagg tcacagaaaa aatataatga atccaaattt cagtaaaata ggtgttggag
    67981 tagcacaaaa aagtggtggt tcaatttatt ggacacaaat ctttgtagga taaaatactc
    68041 tttttccata catatcaaaa gagtatctct aagtgataaa aaacacaaat gagatactct
    68101 tttgtatcta ttttaaaatt atcaaatcca aatatacata ctataaatat tatttgttct
    68161 cttaatttta gtgtgtagaa caatatataa aaagtattgg caagatgaaa atggaaaact
    68221 taaaaaagat atttaatagg taaaaacaaa atcttaatat cttcataaaa aaaggctgtc
    68281 tcaaaataga gataaggcct ttttcattgt tgaaatgatt aaaatatatt tgatttcata
    68341 caaaaagagt gcctcatgaa ctaaaaagct cactttgaga cactctcttt tatcaattta
    68401 tataagcatt ataatacttt aatattattc agctaatttt ttgtatcctt catatctttc
    68461 tttagcatca gcttcagctt tagcaaataa tccatcagct tcttctggga attgtttagc
    68521 tatagcagaa tatcttactt gtgcaagtat gaaatctttg aagcttgcag ttggttcttt
    68581 tgaatctaaa gtgaatgggt ttttaccttc agcttttact tctggattga atctgtataa
    68641 atgccagtat ccgcaagcaa cagcttgtgc ttcgttagct acagttcttc ccataccttc
    68701 ttttaatcca tggtttatac atggagcata agctattatt agagatggcc catcatgttt
    68761 ttcagcttct ataacggctt tgataaattg gtttttatca gcacccatag caacttgagc
    68821 tacatatacg tttccatatg tcatagccat cattcctaaa tctttctttc tagatttttt
    68881 acctgaagca gcaaacttag ccatagcagc agctggagta gctttagaag cttgacctcc
    68941 tgtatttgaa tatacttctg tatcaaatac aagtacgttt acatcttcac cagatgcaag
    69001 aacatggtct aatccaccgt aaccgatatc atatgcccaa ccgtctccac ctagtatcca
    69061 ttgagatctc ttaactagat aatcttttct atcttttata gcttttacta actctttagc
    69121 tttttcatct gtacaatcac aagctggttt ttctaataat tcaacaacct tagcacttgc
    69181 tactttagaa gcttctccat catttctaga atctaaccac tctgtaaata ctgctttagc
    69241 atcttcacag atacccatag aaactaactc tgtcatagca tctactattt tatttcttat
    69301 ttgcttaaca gctgtgtaca taccaaatcc atattcagca ttatcctcga ataaagagtt
    69361 tgcccaagat ggacctttac cttcatggtt acaagtataa ggaattgatg gtgcagaagc
    69421 tccccatata gaagaacatc cagtagcatt agctatcatc attctatctc catataattg
    69481 tgtaactact ttaatgtatg cagtttctcc acatccagca catgctcctg aaaactccat
    69541 taatggttgt ctaaattgac ttcctttaac agtgtttaca ggcataacat caccttttgg
    69601 agctacctca tcaggattta ctgcaaatgc ccaattatct aactctgtat caagttgagt
    69661 atctattggc ttcataacta aagctttttc tttagctgga catatgtcag cacagtttcc
    69721 acatcctgta cagtcaagtg gactaagttg cattctatat tttaatcctt ctaatccttt
    69781 acctaatgct tttttagctt caaatccttc tggagcatta gctaattctt cttcagtaac
    69841 taatactggt cttatacatg aatgaggaca tataaaagaa cattggttac attgaataca
    69901 gttatctatt atccattcag gaacatcaac agctatacca cgtttttcat aagctgcagt
    69961 accacaaggg aatgttccat cttctatacc attgaatgta cttactggta agttgtttcc
    70021 ttcttgtgca gtcattggtc ttagtatatt ttttataaat tctggttctt taacttctcc
    70081 tttatctgca tcaacagcat tttcccaaga agctggaact tcaactttaa ctaaagcatt
    70141 tattcctgca tcaacagcag catagttcat gttaactatt ttttcacctt ttttaccata
    70201 agctttaact atagaatctt ttaagtattt aacagcatct tcttctggta ttatttcagc
    70261 taatttaaag aatgcagatt gcattatcat atttattctg tttccaagac ctatttcttg
    70321 tcctagttta acagcgttaa ctgtatagaa ttttatatca tttttagcta tatattgctt
    70381 catatgagct ggtaaatgtt cttcaagtcc tgcttggtcc catatagtgt taagtacaaa
    70441 tgtaccacct tttttaagac cttttaataa atcatattga taaacatatg attgtttatg
    70501 acaggcaata taatcagctt catctattaa ataagtagct cttattggag tatcaccaaa
    70561 tcttaagtga gacatagtta taccaccaga ttttttagag tcataatcaa agtaagcttg
    70621 agcatatttt tcagtatggt caccaattat tttgatagct tgtttattag ctccaacagt
    70681 accgtcagaa cctaatcccc agaacttaca tcttatagtt cctttagaag ctatttttat
    70741 tggctcagat ggagttaaag aagtattagt tacatcatca actataccta ctgtaaatcc
    70801 atttttaggt tgttctgaaa ctaagttatc aaaaacagtt tttatatctg aaggagtagt
    70861 atcttttgaa cctaatccgt atcttccacc tattatcata ggagcatttt cttttccata
    70921 gaatacatca cgtacatcta agtataatgg ttcaccagtt gaacctggct ctttagttct
    70981 atcaagtaca catattcttt caacagtaga tggcatagca tctaagaaat gtttcattga
    71041 gaatggtcta tataaatgaa ctttaactaa accatatttt tctcccttag catttaagta
    71101 atctatagtt tcttctattg tttctgttac tgaacccata gctattaata cgtatttagc
    71161 atcttctgct ccatagtaat caaataaact atgttttcta cctgttaaat tactcatttt
    71221 ttccatgtat ttttcaacta tacctactat attttgatag tatttattag aagcttctct
    71281 agtttggaaa tatatatctg ggttttgagc agtaccacga gcaactggat gatttggaga
    71341 taaagcatta tctctaaatg cttgaactgc ttcaaagttt aataaacttg cataatcttc
    71401 attttctagt aattcaactt tttggatttc atgtgaagtt ctgaatccat caaagaaatg
    71461 tataaatggt aatctacctt ctattgcagc taaatgtgca acaggtgcta tatcagctac
    71521 ttcttgaact gaaccagaag ctaataatac acatccagtt tgtctagcag ccataacgtc
    71581 ttggtgatcc ccaaatattg ataacgcttg agatgctaaa gcacgagcac ttacatggaa
    71641 tactcctggt aataactctc ctgcaacttt atacatgtta ggtatcatta ataataaacc
    71701 ttgagatgct gtaaaagtag aagttaaagc tcctccttgt aaagaaccgt ggaatgttcc
    71761 tgatgcacct gcttctgact gcatttcaac aacattaact gtttgtccaa atatattttt
    71821 tcttccttgt gatgcccact catcaactac ttcagccata gttgaagatg gtgtgattgg
    71881 atatatagct gctacatctg taaacgcata ggcaacatga gctgcagctg tatttccatc
    71941 aagtgttttc ataaacttag ccataatatg tatcctcctt gatagctaca attgtacttg
    72001 tttataacaa gtctattttt ttatatttac atataattta cacaacaaaa ctataaacac
    72061 acatatagtc gcgcaaatac tctatcttct aatataatac tacagattag ataaaattcc
    72121 tttgaaaatt gtaaattaat tacatattta agtagatttt ttttaaaatt aaatatgtta
    72181 agtttttttc ataattttgt atacaatata taataaatta agttagattt ttcaaacttt
    72241 tttatctatt tgttcatatt agtataaaaa gtaaaatgct tatccttatt acatgtaaat
    72301 ttttatatat ataattttac catattacat catatttttg taagttttta ttacattttt
    72361 tataataccc ctttatttta taaattaatc taatcgatta aatttatcct atagaaattt
    72421 attacattta aaaatatgct agcaaataaa atatctacta gcataaagtc tatttataat
    72481 attaatcaac tattaattct actaaatctc catttttaac gcctgctgca tttccctctt
    72541 ccatatcaac atgcatttct agattaaagc tgtcactagc tcttactaat acattttcaa
    72601 atactaatgc tcttggtcca gatgttttaa cttttactat ttgcttatca gttacaccaa
    72661 atttagcagc atcttcattg ctcatatgta tatgtctaga agcaactata actccttctt
    72721 tcatttcaac ttctccagca ggtcctacta atttaacacc tggagttcca gctatatcac
    72781 cagattcttt tattggtgct tttactccta atgggaaacc atctgctaaa gatatttcaa
    72841 cttgagtatg agctctagct ggtcctagta ctctaactcc ttttaaagtt ccttttggtc
    72901 ctactaaatc cactttttct tcacaggcat attgccctgg ttgagataat ggtttaaatt
    72961 tagttaactc atgacctgcc ccaaataata cgtctatatc agcttgactc aaatgaacat
    73021 gtttattaga taatgctatt ggtaatttca ttgaaattcc ctccttttaa ttatttaaat
    73081 tattgcaata caattataca taatattacc tacaaaatca aattatattg aatcaatata
    73141 tatctttaaa tttttatata ttatatcttt aaattcttga ttatctatat aagatacatc
    73201 atctgtattg tttaaatata tattgtgtaa aagtttagta tttatactct taaagaaaaa
    73261 atccatcaca atctgtccac ctttaaactg tgaatcatat gatttactcc cccccactgc
    73321 aatatacatt cctatccgtt tcttacttct atcaattgaa ggtttattta atacatattt
    73381 acttgcatat atagcttgag ttctatcaac aacagtcttt aatttagctg atattgaatc
    73441 aaaatgtaca ggacttatta ctatagttcc ttttgaatca tcaaacattt tatataatgg
    73501 cttcatatca tcattaaact tgcaataccc tgttttttca caaaatccac atgctgtgca
    73561 atattcaata tccatattgt agatattaaa tattttacaa cttaatccac actcttctag
    73621 catagctttt acttcatttg ctataaaact gcaattttta ttaattcttg gacttccatt
    73681 tattattata atctctggac ttttaagtcc ttttttatcg tttgaatcca taatcaatct
    73741 acctatcctt taacataact attaaaatat catcatcata attatctttt gatgagaagt
    73801 tctttaaatc caattttaga ttttctacta ttaactgttg atttaatcta aaattttctt
    73861 ttagaaagtt ttctaatcgg tttataccat actcttcttt tgatgaattt tttatctcta
    73921 aaattccatc agtgtacata cataccattg cataatcttc cattgaaaga gtattatttt
    73981 cataagtagc atcttccatt attccaatag gtatgccctt tttacaattt aaattatttt
    74041 ctattgtgcc atctttcttt acaactacag gactatagtg acctgcatta gacacagtaa
    74101 tcatattttc tttagtatct ataataccta tcaaacaagt tgtaaatact cccatcttgt
    74161 caaattcatc atataacatc ctatttaaat ttgtcattat ttctcttggt gtattgtatt
    74221 gattgcataa tactttaaaa gcacctttta tcattgcaac aacataattt gataccattc
    74281 catgtcccat tacatcagca acaatataaa ctatatgttc gtcatccact tttgtagcat
    74341 aataaaaatc tccacctact acccttgctg gtttatggta aaaataaagt tctttctcat
    74401 cattacaatc cattttacct ttatccataa taagctgttg ttgtttattt aatatgttca
    74461 actcgttttc aagaactttg tgttttactt ccttttcatt atgttcatat aattgcatac
    74521 caacagaaac ttgtttggac aatatactaa gaatatttaa atcatcacta gtatagtttt
    74581 tgctatttgc acaaactata catcctatag tatcattttt atcctgaagt ttgtaatata
    74641 tataactttc caaatttatt cccttttttg agcatggttt taaattattt agataccccc
    74701 ccaatgactc tttctttaaa aacatatcaa tcataggata taaatttgtt ttcttttttt
    74761 gctcaacatt ataacaacta actatagcat ccttattatg atgactattt ataattatta
    74821 aagcttcttt actattagta atattacacg cttgtttact taaattttcc aaaaagccat
    74881 caatactctt attaaggtat agttttttag tagcttcatt tatggcactt attgagcctc
    74941 ttagtttatc aattaaaatt tgtacattat tatttttatt agttatttct attgataaac
    75001 ttaagagtga tgcaacagat gatataaaat ctatatcttg ttctgttata taatcatcct
    75061 cttttaaaaa acaagtcata aatccaacaa ctacgttatt tattataaaa ggaaaaacta
    75121 ttctcccaat ataaccttca gcttttgcta aatctcgttc accttctgct ctagaatctt
    75181 caaatacatt ttccacatat attatctttt tttcatttac agcctcatgt atatactctg
    75241 gatatgtgtc aaaatcaatt tttgcacctt taagactatt tattggaaaa atttgaggta
    75301 catattctaa ggtttgcgaa catactaagt aggcatattt agaatcattt ttataaaata
    75361 gattcacaca tgcctttgta gggtgaacaa cttctaacat tttttctatt atgtcatctt
    75421 ttatattaaa aaaatctgta gattcagtca ccatagcgga tatttccact aaattcttca
    75481 ttttataact gccattagtc atactcaatt tctcccccta tatattaaac tatttattag
    75541 tattttaaca tacattcttt atagtaaaaa caaaaacaac gacaaaacta gcaactaata
    75601 tccagttaaa tcctgtcaat aatcctataa gaagtaatgt aattaatgca tttagacctg
    75661 ttctcccttt ttcatccata aaagttattt tagagatgtc gatattattt ttcacattat
    75721 ttatatgctc tttcacttgt tcttccatat ttcttttata tagtatataa actacaccaa
    75781 ctaaaaacac tcctatacct aaaaccatgt ttaaattaaa agctaccata agcaatattg
    75841 aaccaaaagc taactttaaa agcttaaaaa atacactatc tatctttaga gttatatttc
    75901 tgatttcttt acattcatct cttaaagaat atccacttga atctaagtta ttaatctttg
    75961 tttttacaat ttcagaataa aaaagcttta ttatcccatt taacattttc atcactccta
    76021 aatattttac atatatttgt aa
//
LOCUS       DAEHWM010000004        71638 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.004, whole genome shotgun sequence.
ACCESSION   DAEHWM010000004 DAEHWM010000000
VERSION     DAEHWM010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 71638)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 71638)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..71638
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.004"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            483..1550
                     /locus_tag="KNP36_000311"
     CDS             483..1550
                     /locus_tag="KNP36_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0872208.1"
                     /translation="MKFKKLVSLGILSTLLLSVITGCSNVSSGSNLKSNNKTKGELTV
                     YTAIEEDSIDTYLATFKEKYPDIKLNVLRLSVGGITARLLAEKDNPKADVLWGVAATS
                     LIILDDKEMLEPYAPKGFDKVNSAFKDDKKVPSWVGIDAWMTGITVNTKELKAKNISA
                     PSSYEDLIKPEYKDLISMPSPASSGTGYLTVSELIQIMGEEKAWQYMDKLHKNIGVYT
                     QSGSAPAILAASGEYPIGISFGNRGIKLKGEGYPVEVVFPKEGSGWEIESNALVKKDN
                     IKEASKVFLDWAISKDAMNEYSKNFAVTTIDTGNPVPEGFPKNPLEQMIDNDLKSAAR
                     NREAILNKWIEKYDGKTEKES"
     gene            1742..2272
                     /gene="rnmV"
                     /locus_tag="KNP36_000312"
     CDS             1742..2272
                     /gene="rnmV"
                     /locus_tag="KNP36_000312"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HBF0872209.1"
                     /translation="MIKEIIVVEGRDDVTAVKRAIDAELITTGGFGFPKGVMERIKAA
                     NERRGVIIFTDPDFAGEKIRKKIASEVPGCKHAFLPREEAKKDGDIGIENATPQSIIA
                     ALNKVRTENTEKRDEFKQVDLIRNGLIGNEEASLRRDALGKILGIGYGNAKQFLNRLN
                     NYGVEREEFIDALKQI"
     gene            2443..3312
                     /gene="rsmA"
                     /locus_tag="KNP36_000313"
     CDS             2443..3312
                     /gene="rsmA"
                     /locus_tag="KNP36_000313"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HBF0872210.1"
                     /translation="MDRLSSHNATKEVVQKYNFKFSKSLGQNFLIDSNIIDKILSGAR
                     ITRGDNIIEVGPGIGTLTREMGKIAEKVVAIEIDRNLIPILKDTLSDLDNTEVVNQDI
                     LKVDIQELVKDKLNGGPVKLVANLPYYITTPIVMKFLEEDIPVTDIVVMVQKEVADRM
                     NAIPGTKDYGALSIAVQYYCDTEIVAKAPRHMFIPQPNVDSTVIGLHVRDKRKYDVHN
                     EDIFFKTVKASFGQRRKTLLNSLGGLGFLNKDEIREVLKEANIDEKRRGETLSIEEFS
                     VLSNIINTKVSSK"
     gene            3378..4640
                     /locus_tag="KNP36_000314"
     CDS             3378..4640
                     /locus_tag="KNP36_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872211.1"
                     /translation="MGSKRKFKRDYIILEAKDINFRYKERVLPKAFAKVEVNDEKAII
                     ALYVENLKYVKDGYKAVAIKDDHGLIDLGNIILNEQGRGEFVLDLEDYDDEIKGIALL
                     YERNIPLIGFKGNKLENYEDILFQEVEEEEYEEYEELEEEDEEIEENEESDRDEDSEE
                     EYIIEEYDEDEYEDYWEDDEDIEEGELKARTEVEDSDDEEIEEFNNYKEIENYNRVKV
                     QEEYIDIEYDEEEEEEEVFEVNREEDRFVSSKPTKSKKVQKDQNNIEKIKRANGVSQG
                     ESGNKQTSTLLMPRQIKKGLKLFKEVKPFVTDYIDKTRWWKIEINPTTLCGYTMPYLG
                     YLNVLNYTMYSDAVLHSYKYRHYLFGVQYDEYNKRKHYIYAIPGNRNEQPDNGSTGFL
                     RYQACDNRTNSLGYWLCFIDSRQRNIVR"
     gene            4791..5906
                     /locus_tag="KNP36_000315"
     CDS             4791..5906
                     /locus_tag="KNP36_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBF0872212.1"
                     /translation="MINEQRILNEFLELVQIDSLSLKEGNVAKVLVKKLEEIGCSVVI
                     DNAGEKANGETGNIIATLKGNKEGKKILFSSHMDTVTPGIGVKPIVDEANGIIKSDGT
                     TILGSDDKAGIAAILEGLRYINENNIEHTDIQVVFSICEECGLVGAKNLDYGKIDSEY
                     AFILDSGGSPGEIIVKAPAQDVINVKILGKTAHAGLEPEAGISAIMVAARAIENMNLL
                     RIDEETTANIGIINGGTATNIVTGEVNIVAEARSLKENKLDVQTKHMVETFEKAAKDF
                     GAQIEIDVNRAYTPIDVSEDSEIIKLAKKAFSNLGIEGHTESTGGGSDTNILSKNGIE
                     AITLGIGMKNAHTLSEHIAIKDLYDSAKMVVEIIKEA"
     gene            6092..6988
                     /locus_tag="KNP36_000316"
     CDS             6092..6988
                     /locus_tag="KNP36_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBF0872213.1"
                     /translation="METRYEEANKITIQSILWNIVLTIIKVIAGVIGNSSAMIADGLH
                     SASDIISSIGVLIGNYVSSRPGDREHNYGHEKAETLVSFVLSILLIFVSITIGIEAIK
                     SLFNLDALSVPSILPLVVSVISILIKEYQYRITIKVAKKINSPALKADAWHHRSDALS
                     SVAAFIGIGGSILGFKPLDPIASVVVAIFVAKVGISILISSVNELMDVSVDEEEIKEL
                     KFIVADTEGVKNLGDIKTRKHGAMAYVDLTICVDENLTVKQGHDIATKLEKHIIKHME
                     FVKGITVHVEPCTNCQGNKCNN"
     gene            7058..7855
                     /locus_tag="KNP36_000317"
     CDS             7058..7855
                     /locus_tag="KNP36_000317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872214.1"
                     /translation="MSKKRKLKKKAAILIGVVVFFIIYFISFRIGINMEKDKSEVPKK
                     VEKEEEDNRSLRTQIKEKKKVYISDKNIENIKIEEDMWDEIKLFFSDFKKVRNTTSSY
                     EAVYEGYSDDGVKFSTDLNFFRVYTVNKEEYYKVPVSSKDAFKKLLDESIYTSFDLLS
                     HYKDWKEVTITHGKEIKKVHRWKFDDLAHKMISKRVVGKVQPEKSKERSDYNFTINIK
                     GDNFDVKVDTMGKDYVKVTSKKNVSYYEVHTSLFDYLKNEIFEIGKK"
     gene            complement(7910..9262)
                     /locus_tag="KNP36_000318"
     CDS             complement(7910..9262)
                     /locus_tag="KNP36_000318"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HBF0872215.1"
                     /translation="MNIHFIGIGGISMSALAEICINKGYQVSGSDSNESYLLDKLRDQ
                     GATIYIGQKKDNISDDVNMVVYTAAVHPDNEELVAAKEKNKLVMNRATFLGQIMREYK
                     NSIAVSGTHGKTSTTSMLSTIFEYADLDPTILVGGNLSMIGGNVKIGNSNHFITEACE
                     YVDSFLNFNPKISIVLNVEEDHLDYFSGIDEIKASFNKFGKLLPPEGYFIINGDDENI
                     DDILYDVKATIIKYGRDSDNDAVIKDIHFDNSGHGIFRIEYEGRDLGEFELSVYGLHN
                     IYNASSAIMAALVSGIDLETIRKNIKIYKGVGRRFETKGYYKNALVVDDYAHHPTELK
                     ATLAAAKKLKKSTLWCIFQPHTYTRTKSLLGEFSEAFYAADKVIITDIYAAREKDPGD
                     IHSKDLVEKLYQNNVDAIYIKEFEDIVKYLRENVKDNDLVITAGAGPIYKVADLLVEK
                     "
     gene            9481..10359
                     /gene="purR"
                     /locus_tag="KNP36_000319"
     CDS             9481..10359
                     /gene="purR"
                     /locus_tag="KNP36_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HBF0872216.1"
                     /translation="MKFKRTERIGAIVKILSDNPNKIYTLSYFTNQFNAAKSTISEDL
                     LVVKNVFEKLHLGKVITISGAAGGVKYIPKTSIAENAEFLMELCERICDKSRILSGGF
                     LYLIDLIYDPTIAAKIGKIFASNIEYVDADYVVTMETKGIPMALMTAKAMNLPLVIIR
                     KDIKVSEGPTLSMTYVSGNSSKVESMSLPRKALKPDSKVIIIDDFMRGGGTIKGMVDL
                     MNEFGAEVIGTGVFISTTNPSEKMVKDYISLIQLDVNGDKIVVEPNLKTFKDEYRNED
                     LDEEEDSEFEFEIDED"
     gene            10515..10793
                     /gene="spoVG"
                     /locus_tag="KNP36_000320"
     CDS             10515..10793
                     /gene="spoVG"
                     /locus_tag="KNP36_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation regulator SpoVG"
                     /protein_id="HBF0872217.1"
                     /translation="MKITDVRVRKLTEEGKMKCIVSITFDNLFVVHDIKVIEGHNGLF
                     IAMPSRKVGEGNFRDIAHPINAEMRQVLEDAVLQAYHEALVQWEVAAE"
     gene            11006..12385
                     /gene="glmU"
                     /locus_tag="KNP36_000321"
     CDS             11006..12385
                     /gene="glmU"
                     /locus_tag="KNP36_000321"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HBF0872218.1"
                     /translation="MNFKAIILAAGKGTRMKSKYPKVIHKVCGKEMVNHIIDVSKKSG
                     VKDTVVILGHEADVVKEKLAEEIIIAMQTEQLGTGHAVKMAKEYINDEDTIVVLCGDT
                     PLIKEETLKRLFEYHIENKYHATVLTTRVGNPTGYGRIIRDKKGDLLKIVEQKDANSE
                     EKMISEINSGIYCFNGKSLREALDLLNNNNSQGEYYLTDTAKIMRDKGLKVGAFAGST
                     IEELMGVNSRVELSKAEEIMRRRINESHMVNGVTIIDTNSTYIESDVMIGNDTIIYPG
                     VMLQGKTRIGSDCIIGMNSSITNSEIGDGTEIKNSTIIDSKVGENSTVGPYAYLRPKS
                     DLGNNVKIGDFVEVKNAIIEDGSKASHLSYIGDAHVGKNVNIGCGVVFVNYDGKNKFK
                     SIVKDNAFIGSNSNLVAPVVVEEKGYIATGSTITHDVPDGALAIARERQVIKEGWVEK
                     KNQKDDQSK"
     gene            12480..13430
                     /locus_tag="KNP36_000322"
     CDS             12480..13430
                     /locus_tag="KNP36_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate pyrophosphokinase"
                     /protein_id="HBF0872219.1"
                     /translation="MNTSGSEIKIIAGNSSKELAQKIADYIGVSVLDCEVGTFSDGEI
                     CVNMNETVRGCDVFVVQSTNSPVNDNLMELLILIDALKRASAGRITAVIPYYGYARQD
                     RKAKARDPITAKLVANLITAAGADRVLTMDLHAAQIQGYFDIPLDHLLGGTILANYFN
                     EKKIEDLVVVSPDLGSVTRSRKFANTLNGEVPIAIIDKRRPKANVCEVMNLIGDVKGK
                     NVILLDDMIDTAGTIVNAANALKEFGAKDVYACCTHGVLSGPAIERIANSEISELIVL
                     DTIQLPEEKRIDKIKIKTVAPLFGDAIRMIFSNESVSKLF"
     regulatory      14268..14353
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            14515..15036
                     /locus_tag="KNP36_000323"
     CDS             14515..15036
                     /locus_tag="KNP36_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBF0872220.1"
                     /translation="MKLKKNKKGFTLVELLVVIAIIGILAVVAVPALFSNINKAKVAS
                     VESDYSSVKSAALSYYSDTNKIPVTPDGQTGLSVLETYMESLPDKADIGGKYKLIKVG
                     NKLVLQIGTNTEGVTLTEAQSAKLLSDIGENKIYTSATTNSLGNPLTSNTKIDNNVLY
                     IVLIDNTVMDTTK"
     gene            15187..16863
                     /locus_tag="KNP36_000324"
     CDS             15187..16863
                     /locus_tag="KNP36_000324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HBF0872221.1"
                     /translation="MAKKVRIGDKLVEKGYITEEQLKWALSEQKNSGKRLGEFLVQEG
                     LIDSNLLISVLKELLDIESIFLEGTEIDTLATKMVPENICKRYTVFPFKIDGNKICLA
                     MSDPQDREAVQDVRRMSGKDVEIFISSTEDINKAIGHAYAHSEINKAMTEYNKNRTGG
                     VRETVILEEDVNAAPIVRLVNNILENAVRMEASDIHIEQSENYMRVRFRIDGMLREYM
                     RMNSAPYKAVISRIKIMSDINISEKRIPQDGRIYLKVDNKPIDFRVSTMPTNRDEKIA
                     MRVLDKSNFMVSKEVLGIDEHGSKIYDELINTPYGLILVVGPTGSGKTTTLYSMLNQL
                     NTENRNLLTIEDPIEYELPGVNQSQINEKAGLTFASGLRAFMRQDPDIIMVGEIRDTE
                     TAEIAIRASLTGHLVLSTLHANTAVGAISRLLDMDVESFLITSSVLGVISQRLTRKIC
                     EHCKVSYEADIGEKKALGIDVNESVTIYRGKGCERCNNTGYKGRLGIFEMLEITPEIK
                     ELIDSSANQREILKMARKQGMVSLKEDIVKKVLNGKTTVEEMIRIILMTD"
     gene            16875..18083
                     /locus_tag="KNP36_000325"
     CDS             16875..18083
                     /locus_tag="KNP36_000325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HBF0872222.1"
                     /translation="MKSFKYTVIKEDGKKQTDVIEANDFNEARNLLRKRNLRVIEIKE
                     SKNKNIRLSSRKRKKDLGADQISHFCRQFAIIVSSGINSISGLETLARRSTNITLREE
                     INRIVAEIKVGSTIADSMLSSKSKFPKLLGAMVATGEATGKLDEVLKSMASFYASEHR
                     VKQKLRNAATYPLIVLISSFIMIFIFTTFMVPKMINSITTVGATLPLITRIVMGFGMF
                     MKKFWIIVLLVIILFIYQFKKYLKTSVGRAHKDRVINKIPVLGKGINCMVATRFSRAL
                     YLFVSTGYPLVQGLDYIIDSVNNTMAEKILASAKDGITRGEGLAENLERYTYFDSVLV
                     QMIAIGEQTGELENISRQMAEFYEYESEIYLNRMASMIEPVLIIAVGIIVAILVVSIF
                     MPMLSIYDAM"
     gene            18098..19810
                     /locus_tag="KNP36_000326"
     CDS             18098..19810
                     /locus_tag="KNP36_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PilN domain-containing protein"
                     /protein_id="HBF0872223.1"
                     /translation="MNKVYVSYYGDSISIVEGRYKHDKDKFYVKNFNVFSIEDIAQDF
                     SKEKYALLRYALENVKLKSRHVVFCLNTRDVILKPQKLPNMDKKDLDGFMKLEMDEMM
                     ALESDEYVFSYEVSSETPDNSDGDESSLNLIIGAIQKEEVNAIVEIMHEFDLVLDRID
                     TLSTAYLRMLKNLDYNDIMVTNISDNSTIINIYKKDTLFISDNIPIKITAKDMDMQLL
                     NVVEESKGLMNYYSSRNFGKVTDTILILGKRYSNKLIYETFSSAFSSYVSQGLTEIMD
                     ISDMITGDIDEDDINSIVELLGSMIEPKGKRDFENINFLPMDILRKQIKAKQMKNILK
                     IAPIVILILAIPYLCLIFSNNLANKELENVNGEIRNIESAYYQIGNIEKMIQSKSEEI
                     KVYDMLIGKKVKWENLLDDIDKNTPSKVELTSLSTTYQNLGTNNKADNSKSNKTTTDK
                     SSNNETKSSTKSDSNGDKTDNDLNEDKTTNVSEALTGNSETNSNNTDKDDKTPLYDKI
                     PNVINIEGNAKDSSYVGQFLYKLKGLYYFKDVKLHSIKSNAEDSNYTFSMTLYLKEGV
                     LTNE"
     gene            19803..20711
                     /gene="pilO"
                     /locus_tag="KNP36_000327"
     CDS             19803..20711
                     /gene="pilO"
                     /locus_tag="KNP36_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 4a pilus biogenesis protein PilO"
                     /protein_id="HBF0872224.1"
                     /translation="MNKDIFKKDIKDIFKMEVSLKGILIKVIILLAILSYGYFGLYPQ
                     YQKYIATKNSVKQATEKLNIYKEKTALMPKYEKQLEEVESELKEKSKNLLYDMQDGLF
                     LIGLDKKMKAYNIDLTSYDVGNVKEYEHFYGISTTISVRGDYRNVKKLMAYLEEQKNV
                     TQILDYTMTSYIEPEKEEEETTNNKDLIKNVNINKDTKIYWVEGENKWHLYKDCPLIK
                     EGEILKNDKLLDRSTNYLCNTCVLRAATEKEAKKEVVAPKAEGVVDATFKFIMYTKEN
                     TTMILDTDNPSSWRPGKYNPFKSSAK"
     gene            20738..21304
                     /locus_tag="KNP36_000328"
     CDS             20738..21304
                     /locus_tag="KNP36_000328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBF0872225.1"
                     /translation="MSLYKNNEKGLTLLEVIIAVFILTIVLSISYKVFNGITSAVKKQ
                     QIITDAQVNINLINKYLNRDLENCKELTKTGSGNNYEYNIEMPDNVVKYEVSIETKKN
                     TEVYSVTRIQNNTIDTENEVREEIIYNQPLVQNNKEMKETPFKIEKQTGKSIYTVSIY
                     YNESVQESHKNSNLNNKTYTFDVMSRIG"
     gene            21341..21868
                     /locus_tag="KNP36_000329"
     CDS             21341..21868
                     /locus_tag="KNP36_000329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBF0872226.1"
                     /translation="MSKKNSERGFSLIEVLVAMAIMGIVLFAFFNIINTNNKANTKND
                     TDITSLNYVQSEIENLREKIKSGEFDFDSLDKLEDGTVVYEKLIDKSKKVVYDKVLSE
                     GDVSLYDTPYEKITTIKDEDGNLIDKGNITNKIKTIVEDKSGQIYKIAVTGKSMNDYS
                     SKKEVKIVTEIFKDK"
     gene            21889..23427
                     /locus_tag="KNP36_000330"
     CDS             21889..23427
                     /locus_tag="KNP36_000330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872227.1"
                     /translation="MRKWNKFKSERGAALVLVLVVVALLSIVGLIFSNQIANRIKSTK
                     TTNEGIQAKYLAETCVENSIDKAYEKLYDELEKMDNEFKSENQEKSISRSKLRDISDE
                     DFNNQDEENIEAERLGYMNNINFYLNKASSDLEKASMELKKLYDLYMLDYRDIEYVDA
                     NIISHRDSILEICKNYTSGDISKINEYILKEDIDSTTLIEAKLVNNDILLKMFLEENK
                     IENEHLNSAFSHTYKALDNISLAMQNMIEYRHTFHIDEPKVEVSNGIPDSQQYYELIQ
                     NPIINSMEYIWNSKWDTLEKLLEILPNQTQGFNSLRVHLRNNVRKFEKLSDNISSGKK
                     NTAKNFLKYKELLYEISDQCNQLKSMSYEKIPVKYDNMALITTFDYIQNELLAEIKCR
                     LKELKPQEIDKTEGITIKIPFYKADYDMTKEGWPKLKENGSGAELSLMVTGDKDGIKE
                     VEVTDGKKNIIGLGVEENSNSKYKVDAIVNFNLNIDTNVVGNYDIKDKILINHDISSY
                     KKVN"
     gene            23527..24609
                     /locus_tag="KNP36_000331"
     CDS             23527..24609
                     /locus_tag="KNP36_000331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV pilus twitching motility protein PilT"
                     /protein_id="HBF0872228.1"
                     /translation="MYIYDLLEQGIRLNASDIHITVGTNPVARVKGGFVKLSEQILTS
                     EVTMQMAKDIAGESMFKVIEEHGEADFSASLKTGERFRVNAYRQKGNYAIAIRTITAE
                     IPTFEKLGLPESIKSFTEKHKGLVLVTGPTGSGKSTTLASMINIINEKQQKHIITLED
                     PIEYVHHHKQSLVNQREVGTDTESFHSALRAILRQDPDVILIGEMRDPETVSIALTAA
                     ETGHLVFSTLHTVGAAKTIDRIVDMFQPSQQQQIKTQLSTVCEGVVSQQLLPTADGKG
                     RIAAIELMFATPAIKNLIREGKTYQIPNMIQTGVKVGMKTMDQDLMELYKNGKITKDM
                     ALSRCTDQEFMTRMIGGVNYNGYYNR"
     gene            24590..25372
                     /locus_tag="KNP36_000332"
     CDS             24590..25372
                     /locus_tag="KNP36_000332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HBF0872229.1"
                     /translation="MDIIIVNLYVFMVGIVFGSFFNVCIFRIPEGISISRPPSHCMSC
                     NTRLKPIDLIPVLSYLMSGRKCRYCYEKISSRYAIVELITGLLFLTVFMLYGISTSTI
                     YYLVLVSLLIIITFIDIDHFIIPDKILVFGAIFSMIFNLLFKEIPVKDSILGVFICGG
                     SVWIIVLLIEFVIKKECMGGGDIKLFAMLGFYMGVKNGLLTALLSVYVGAVYGICVII
                     ISRIKGKEYNSVIPYGPFISIGALITILCGKQLLELYFSMVI"
     gene            25474..26124
                     /locus_tag="KNP36_000333"
     CDS             25474..26124
                     /locus_tag="KNP36_000333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HBF0872230.1"
                     /translation="MEYIIIISLFFAHLINKSLCVFCDREKKNLYNTFFIYIITVVLS
                     VLIYLKFGISVECVQYMVLIPFLIIISIVDYYTIYVYDITIVSGIIVQGIIFLVFFNI
                     VQFDYINHIFGLLIGFIIPYIIAKLTKGLGYGDVGLYSLCCFALGNNYGFYVIVLSFI
                     LAFLFFIILYITKIFKDVDIRKQIPFTPFISLSTILIIFTEYNIFNFYYNLLYKFI"
     gene            26138..26698
                     /locus_tag="KNP36_000334"
     CDS             26138..26698
                     /locus_tag="KNP36_000334"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HBF0872231.1"
                     /translation="MYVVVGLGNPGKKYEKTRHNVGFDVIDILAKEYNISVTKIKHKA
                     LIGEGRVGTEKVLLVKPQTYMNLSGETLIDIYKYYKVDLSNIVVVYDDIDLEVGKIRI
                     RKKGSGGTHNGMKSITKCLGSNDFPRVRVGVSKPEAGQDLADFVLSRFRKEESDNINE
                     ALEKAADAIDSIIRENIDMSMNKYNG"
     gene            26715..30101
                     /gene="mfd"
                     /locus_tag="KNP36_000335"
     CDS             26715..30101
                     /gene="mfd"
                     /locus_tag="KNP36_000335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HBF0872232.1"
                     /translation="MNDVFLYPLQNSKEYKDIINCIKNTKGSLLVNGLLPVQKPHISY
                     SIFNDLSRQMIFITSSDLEAKKVYEDLSFYMEDKVEYLGFQDIYFYHLDAKDRNEEAK
                     KLKVLLKLANKEKIILVTSIEAVLRKYIPKQVLLDSVSHYKVGDSLDLEKLTEKLVSL
                     GYERVSKIEGFGQFSIRGGIIDVFSLEYTNPIRMELFDDEIDSIRTFDVYSQKSIDKL
                     QQFSITPSREFIYPEKTTDALVKLKKETTKNTDEGTFQNIDYISSKTYFEGVENYIDY
                     IYPEENKSIFTYLADDAIVFINDITRLKERCENYINEFRENYKLNLERGLAIKNQGKL
                     LYHYTDLEYLVKDKSVVLNSLLPKSINNFSIKSIINFESREVPTFNGKVDLLVEELNR
                     LKYNGYKIILATNTLERANKLGKDLLDKGLETTISKDRDIEIKSSQVIIVPAHINSGF
                     QYKSIKFVVITDNEMIGVYKRASKTSNKKVKKGKKIESFLDLSVGDYVVHENSGVGRY
                     TGIEQITVNAIKKDYMKIVYQGGDNLYVPIDQMDKVQKYIGAEVEKVKLNKLGTNEWT
                     KAKAKVKKEIEDMTKDLIELYAKREKIQGYKFSKDTPWQAEFESLFPYQETEDQLKAI
                     EETKKDMESSKVMDRLVCGDVGYGKTEVAIRSIFKACMDQKQVAVLVPTTILAQQHYN
                     TFKERFENYPLRVEVLSRFKTPKQQKQIIEDAKKGLVDILIGTHRIISKDINLPNLGL
                     VVIDEEQRFGVKHKEALKKIKSTVDVLTLSATPIPRTLHMSLSGIRDMSVIEEPPQER
                     HPVITYVTESKESVIQDEIERELSRGGQVFFVYNRVEHIEEMASMIQKLVPDARVAVA
                     HGRMTSKSLENIILGFLNKDYDVLVCTTIIETGMDISNANTMIIYDADKMGLAQLYQL
                     RGRVGRSSRQGYAYLLYEKDKTLSEIAEKRLKAIREFTEFGSGFKIAMRDLEIRGAGN
                     ILGSQQHGHMAVIGYDLYVKMLNDAIKKVKGEPIVEEIDVEIDLSVNAYIPDNYIKDE
                     LIKIEMYKKIASIENKEDMLDIQEELEDRFSDIPKPVQTLLTIAYIKSLCKILKIEKI
                     RQLKDEILLVPITKYRTKQKIGYNIVTELEELLEKMCKVK"
     gene            30132..31127
                     /locus_tag="KNP36_000336"
     CDS             30132..31127
                     /locus_tag="KNP36_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBF0872233.1"
                     /translation="MKKVITLVIAMILVVSVTACSSSKGETVATVEGTKISSDEFKKT
                     IALYKDSMEQTYGKDIWDKEVEKGVKYKDKFKDLILDQLITTEVIYSQAKKDNLLPKK
                     EDVEKSFKELKDAMGKDEKYKEQLKKLGIDDEFLRDQQEKDLAMQNYQSNFAKKTKIS
                     DEEMKKYYDTHKDEFKKDEVEASHILLKTVDDNNKPLSDKEKAEAKKKAEEALKEVKS
                     GEDFAKVAKKYSQDTSASDGGKLGFFSRGQMVAEFEDAAFSMKKGEVSDLVETQYGYH
                     IIKVTDRINEQTSFEDAKETIKDQLLKNKYQEQIEKLTKEAKVEKDEKVINKITI"
     gene            31251..31790
                     /gene="spoVT"
                     /locus_tag="KNP36_000337"
     CDS             31251..31790
                     /gene="spoVT"
                     /locus_tag="KNP36_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein T"
                     /protein_id="HBF0872234.1"
                     /translation="MKATGIVRRIDDLGRVVIPKEIRKTLRIREGDPLEIFTAKDGEV
                     ILKKYSPIGELNEFSQEYAETLAEVLGYGVLITDLDSIIAVSKLPKKDYKEKSISDEL
                     EAIISERTVKYSKDKNILPLFKEDQKEYTSQVIMPIISASGDCIGSIVVVSKDKDTIA
                     ESEEKSLKIAANFLGKQVQ"
     gene            31910..33523
                     /locus_tag="KNP36_000338"
     CDS             31910..33523
                     /locus_tag="KNP36_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBF0872235.1"
                     /translation="MNNNKNKDSFLKGALILGLAGVIVKIMGGFFRIPLGNMIGSEGM
                     GYYQAAYPVYTLFLTLATAGFPTAVAKLVSEKVAIGNFKGANKIFKVSHTVLFITGII
                     SFCILFFGADYIVTNVMKNPGALYSMKAIAPALLFVPAMSAYRGYFQGRQDMTKIAVS
                     QVAEQFFRVVLGLTLAYLLMKSLGQTFGAAGAISGATIGSIASMLYLVFAYMLGRKER
                     RAEIDASQRFKDERVSYIFKKLLTVAIPITIGASVMPLVNMIDNVIVIRRLMEAGFTY
                     KVANSMFGQLTGMAMATINLPAVITTAMSMSLVPAISKAYALGNKSKARKDTKSAVKV
                     TLLIVLPCAFGMASLAIPIMGLLFPHEPSSVGTILFTLTPCVLFLGLIQTLTGIIQGM
                     GKPIVPVIALCVGMLCKIVISYTLTGIPDINVLGSAFGTVTAYFVAAMINLLYVKKHM
                     NVNFSKKEFIIKPFITVMTMFIMVKLSYGALVGFLGNSISTIIAICVGGIVYVVVILG
                     IGGIKKEEILTMPKGDKLYKLLKKVKLIR"
     gene            33630..35078
                     /gene="mazG"
                     /locus_tag="KNP36_000339"
     CDS             33630..35078
                     /gene="mazG"
                     /locus_tag="KNP36_000339"
                     /EC_number="3.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside triphosphate pyrophosphohydrolase"
                     /protein_id="HBF0872236.1"
                     /translation="MGKISIVGLGPGDYSLISQGVLESLINSPKVFFRTEKHPIIDKL
                     KETIQYTSLDYFYEKEENFDNVYLKISEFIIEESAKGDLVYAVPGHPRVAEKTVSIIE
                     RLANEKHIAVEILPSMSFVDAMFNYLAIDPSEGFKLVDAFEIENSYIDLDTSMIITQV
                     YDKFIASNVKLKLMEHYDYNQEVCIVNGAGVKDLESKKFIKLCELDRNENFFDYLTSL
                     YIPKSSKKMYNTVHDLEIIVNTLRSPSGCEWDKKQTHQSLKNSVIEEAYELCNAIDNN
                     DIDEMVEELGDVLLQVIFHCQIGNEEGYFDLKEVVNGICKKLIHRHPHIFSGAKLDMS
                     KFEKTWEELKKEEKGESTITDGLRRIPKHLPALMKASKVQHKAALVGFDWDNVEDVFK
                     KIEEEYQELLDEHRVGNIKYIKEELGDLLFSIVNLARFLDIDSGEALNCTTEKFINRF
                     DFIEKSAMNLNKKLEDMTLEEMDEFWNQAKKQ"
     gene            35167..35445
                     /locus_tag="KNP36_000340"
     CDS             35167..35445
                     /locus_tag="KNP36_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003153447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HBF0872237.1"
                     /translation="MNKAELVSKMAEKSGLTKKEAEAALNAFMSSVQDALVNNEKVQL
                     VGFGTFETRERAARQGRNPRDPEQVIDIPASKAPVFKAGKGLKDIING"
     gene            35517..35759
                     /locus_tag="KNP36_000341"
     CDS             35517..35759
                     /locus_tag="KNP36_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HBF0872238.1"
                     /translation="MRLDKFLKVSRIIKRRTVAKDACDKGIVTINGKVAKSSSEVNIG
                     DTLEIQFGEKKMKFKINEVKEHVLKNDAKEMYEILE"
     gene            35821..36075
                     /locus_tag="KNP36_000342"
     CDS             35821..36075
                     /locus_tag="KNP36_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YabP"
                     /protein_id="HBF0872239.1"
                     /translation="MEQNITLKDRSKLVISGVEHIYSFNDKRVELKTSVGEMVIEGEN
                     LDMSKLSIDENIISIDGTINSMVYAKPKKPQESFLKKVFR"
     gene            36076..36609
                     /locus_tag="KNP36_000343"
     CDS             36076..36609
                     /locus_tag="KNP36_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872240.1"
                     /translation="MIPFTQDVSIFYATIYGGILIGVLFDFYRGLRGNFKFINYFAII
                     FDVLFWFLATVIIFVTINLTEFFDLRYYHFVALFIGFILYYNTISKIVLSIINKIIRF
                     VRNSFKKVTHYIVSFLNNLYYVIIYSLHLLFDIIFYIPNIFIATRKSIKRKSNKKLKN
                     KKKSKPKKKKNKTKKRV"
     gene            36615..36899
                     /locus_tag="KNP36_000344"
     CDS             36615..36899
                     /locus_tag="KNP36_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HBF0872241.1"
                     /translation="MNLRKKFSGQIIVISLFLGISIFSMMTGFVFEYTKAKEYKKEIA
                     SLNKQLKKTEIQINSLKKDEKSYEGDLEDIARKRLNMVKPNETVYVDINR"
     gene            37012..37932
                     /locus_tag="KNP36_000345"
     CDS             37012..37932
                     /locus_tag="KNP36_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ppx/GppA family phosphatase"
                     /protein_id="HBF0872242.1"
                     /translation="MKVGAIDIGTNSMRLLIADYRDGNFINRKKFVNTTRIGYGVDSK
                     GYIKEDAIKRNIKALKEFSDKCNDEKCEKIYCMGTSALRDSKNGDYFVKLAKEETGID
                     VDIVTGIEESNLGFKGVLEGIQGDDTIIVIDIGGGSTEFIVGDSEGIIFNKSENVGAL
                     RMTERFLKHDIIEDEEFEAMSSFIYGEIDKTLNHIKDKGLKTLIGIGGTITSLSAMNQ
                     ELEIYSMEKIHNSKIHKKEIEEILQKLIKMTLSDKKNLKGLQEKRADIITAGVKILNI
                     IMEKLEIEEITVSEYDNLEGLICQKSKKMY"
     gene            38022..40394
                     /gene="spoIIE"
                     /locus_tag="KNP36_000346"
     CDS             38022..40394
                     /gene="spoIIE"
                     /locus_tag="KNP36_000346"
                     /EC_number="3.1.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein E"
                     /protein_id="HBF0872243.1"
                     /translation="MQRSVAVVKNKTVKPNVIKLISGYIDFTTAAFAVMGFLLSRSII
                     VDSVAPLGIAFFICASKIDKYKIPVFISTLLGILLSSNDFGNVAKYAVCLTIFMAMNK
                     KLKLSDSIAKVAFIGAIILLPISMGQAFFSNRYVYGLLIAGVEAIIMFISIYVFSYGI
                     GLMANVNNRMSVRTEEAISISLLLTFSIMGIGDISLFGISIRTILSTVLILLTSIVGG
                     ATMGASSGVIIGVASILNNMTSAVYMGIYSFSGLISGAFNKINKYFCILGYILSWTII
                     YLYTSGITSNMMQLRDILLGCLIVLVLPERLFNKIEKLIKSNVASNEIVYDYIMRSKN
                     LTNSRLNSIYKTYDDLADTFDKIREKDKVLDQRDIANVIDMIHNDECKSCSMRRMCWE
                     SRFNHTYTMIYNILEKIEEKGELSLNDIPKNFRKECMKPESIVKISNHYYKMFVLDYD
                     WSVKFSESRKLIANQIRSISKSIKSLSQDLEGDIMLDIEKEKNIYEQLERYDITVDKV
                     SYLTKSNSEFEISIEKKTCHDGCMCEDKIVNIISDLVGENMSVRKIGCHCLGGKCKAT
                     FVKSQKYKAVTEVSAMSRDGHILCGDNYTYMEINDGKYMMAISDGMGKGKKAYEESSA
                     TIDILEKMIDAKIKDEIVIDTINNMLLLKSSEEMFSTLDLGILDLKRGCLETIKMGAC
                     STYIKREDGEVDLISSSSLPVGILSDVKIDRKNVKVKEGDYVIMVSDGIVDAGRNNNL
                     GDNWLIYFLKNIETTNPKEISNLILDRALELQALQIEDDMTVLVTKICTK"
     gene            40745..42637
                     /gene="pepF"
                     /locus_tag="KNP36_000347"
     CDS             40745..42637
                     /gene="pepF"
                     /locus_tag="KNP36_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HBF0872244.1"
                     /translation="MNRKLCKAIIPLFISIFCMLIISIKADQGYQKNNDRAITVMNNN
                     DTEDDAEKKQEIDYEKTCWNLQSLFKSDDQWKKELKSFDKDTKELKNYIGKVTKSPTH
                     LSFALNIKEKLDIRLNKLSAYVKLKQDTNKNSYKYLDMNDSMSKSYGNYMGICSDLEL
                     EILKLSNKDYKKIISNKNINRKYGAYLRDIRRNKVHYLDDKSEDILSKVSSISSLPSQ
                     VYELFRNMDRKTNLTPAQYASELESSDRENRKKAYQDELITYNDNINTIAGLITGQVK
                     KNIFYSQERGYESSLEMYLESDNVDEKVYNNLIRTVNSNMDSLHKYIDLRKKVLKLDK
                     VHSYDMFVPMVKAVDNNINYEKAQSIVYSALSPLGKEYNDVVYKAFNEKWIDVYSHEN
                     KVSGGYCLSVYENHPYILLNYNNSLGSVSTLSHELGHAVYEYLSSKNQNYFNSNPSIF
                     THEVASTTNEALLYEMLIKEAKGNDEKAYYITQYLDLIKDTLYTQTMYAEFEKTIHEL
                     VEKGKSVNALVLNDVWGQLLKKYYGQSYELDQLSKVGWARIPHFYNSFYVYKYATGCS
                     AGVSFAQDILKNGSDNYMSFLKKGSSDYPINLLKSSGINLTNTKPIENTIKKFDSLVA
                     ELEKLL"
     gene            42751..43716
                     /gene="galU"
                     /locus_tag="KNP36_000348"
     CDS             42751..43716
                     /gene="galU"
                     /locus_tag="KNP36_000348"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HBF0872245.1"
                     /translation="MQVKVKKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPTLQYIIE
                     EAVASGIEEILIITGRNKKSIEDHFDKSVELELDLEKKGKKELLEVVQNISNMINIHY
                     IRQKEPKGLGDAIYCARHFIGDEPFAVMLGDDIVDNDVPCLKQLTDAYEEYRTTILGV
                     QKVNQEDTNKYGIIEAKNIEGRVYKVKDMVEKPESGKAPSNIAILGRYIITPEIFDIL
                     KDLPPGKGGEVQLTDALKILSKKEAMYAYNFEGKRYDVGDKLGFLEATVDFALKKEDL
                     KEDFIKYLKHVCSEFDKNNNVLYNNTDEKIDLIEVNEARELEIQK"
     gene            44216..45820
                     /gene="rho"
                     /locus_tag="KNP36_000349"
     CDS             44216..45820
                     /gene="rho"
                     /locus_tag="KNP36_000349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination factor Rho"
                     /protein_id="HBF0872246.1"
                     /translation="MRRIFLILDDKVLEGLGSKTLVELREIAKELKIKSITTYKKNEL
                     IEIINSKSKNEEKVNEETKEKNEDIKEDIKNRKENIERESIEKEVEYKSPTKSYNKKE
                     IDTQNISQNQEHRNQRNDYNKTTSVNDSNKSSNISNRMVRNNNKNYYMPKQVDESKIV
                     DEFNTSKEDEVVGVLEILPDGFGFLRGSNYLSTEGDVYVSPSQIRRFNMKTGDKIKGI
                     TRHPKSGEKFRALLYVQKINDENPDTAIQRNAFETLTPIFPEERLTLETNRNEIATRI
                     IDLISPIGKGQRGLIVAPPKAGKTVLLKSVANSIAKNHPNVELIVLLIDERPEEVTDM
                     KESIEGDVIYSTFDQVSSHHVKVAEMVLNRAQRLVEHGKDVVILLDSITRLARAYNLT
                     ISPTGRTLSGGIDPGALHGPKKFFGAARNIRQGGSLTILGTALVETGSRMDDVIFEEF
                     KGTGNMELHLDRKLAEKRIFPAIDIYKSGTRRDDLLLDDEEKTALWRLRREMSNNSVM
                     EITDKVIELIKRTKDNKEFVKSIKNL"
     gene            45973..46173
                     /gene="rpmE"
                     /locus_tag="KNP36_000350"
     CDS             45973..46173
                     /gene="rpmE"
                     /locus_tag="KNP36_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018591942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L31"
                     /protein_id="HBF0872247.1"
                     /translation="MQKEIQPKYNPVEVRCACGNTFVAGSTKDEIKVEICSECHPFYT
                     GKQKNIEKGGRIDKFKKRFKMD"
     gene            46318..47211
                     /locus_tag="KNP36_000351"
     CDS             46318..47211
                     /locus_tag="KNP36_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1385 domain-containing protein"
                     /protein_id="HBF0872248.1"
                     /translation="MAKQAVGGQAVIEGVMMQSKDKRAVAVRKSDGEIALKEDRIKSW
                     VRDKNIDKIPFVRGSFVMIDTMIQGIKSLNFSSEFFMEEAEEDKFDLFIKKIFKDKAN
                     DIIIIFSLVIAMLLSAGLFIFIPTLVGGAFSKVMPNDFMLNLIEGIIRIAILFAYIVL
                     ISRSKDIERVFQYHGAEHKSIYCYENDLELTVENARKFKRLHPRCGTNFLFIVMAVSI
                     ILFAFFGWPNPILRIFMRIICVPIVAGLSYEVIRVLGKYDNGFTKIIAYPGMMLQYFT
                     TKEPDDEQLEVALEALKAVVD"
     gene            47229..48077
                     /gene="prmC"
                     /locus_tag="KNP36_000352"
     CDS             47229..48077
                     /gene="prmC"
                     /locus_tag="KNP36_000352"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HBF0872249.1"
                     /translation="MTIKDIIIKYSDKLKDISDTPRLDTELLLQKTLGVDRLYIHLNL
                     NKELTEEQKTKFMGFAEERLNGRPIAYIVENREFMGLDFFVKEGVLIPRPDTETLVEE
                     IIEICREKKDVSILDIGTGSGAITISLAKYIENSKIMSFDISETALEIAKKNAIINEV
                     GEKIKYINSDLFTAISDSNIKFDIIVSNPPYIKKQDIETLHKQVKDYEPYNALEGGED
                     GLDFYRRITEQGKKYLNKCGILAYEVGHNQAEDVINIMKSNGYKKIYTKKDIQGIDRV
                     VIGYNI"
     gene            48121..49185
                     /gene="prfA"
                     /locus_tag="KNP36_000353"
     CDS             48121..49185
                     /gene="prfA"
                     /locus_tag="KNP36_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HBF0872250.1"
                     /translation="MLKKLEVLEDTYKDLSEKIGDPDVINDQKVWQKYIKEHADLEPI
                     VMKYREYKSVLDSIKESKEILQEESDEELRELAKMELAEMEEKVAPLEEEIKILLLPK
                     DPNDDKNVIVEIRGGAGGDEAALFAGDLFRMYSRYAERRRWKIELLSASDTGVGGYKE
                     VSFMIKGKGAYSRLKYESGVHRVQRIPSTESGGRIHTSTSTVAVLPEVEDVEVEINPN
                     DLRIDVFRSSGNGGQSVNTTDSAVRVTHIPTGEVVSCQDGKSQLKNKEQALKILKARL
                     YDKALAEQHKDIAAERKSQVGTGDRSERIRTYNFPQGRISDHRINLTLYKLDAFLDGD
                     IDEMIDALITVDQTEKMTAI"
     gene            49314..49994
                     /locus_tag="KNP36_000354"
     CDS             49314..49994
                     /locus_tag="KNP36_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ZIP family metal transporter"
                     /protein_id="HBF0872251.1"
                     /translation="MILKVTIIGLLAGVIGTGLGGVISAIFKREVDKYLSFFMGLSGG
                     IMLAVVVFDLMKESMDKMGIINTVIFTFVGALITMYIKTKLDVSGNMASGYLIFISIL
                     LHNLPEGLAIGSSFMSTESLGITLAIVIGLHNIPEGLAMALGLVCNKMKLSKVILFTV
                     IAGLPMGLGSFLGVYFGGVFTSLIGVFLATAGGTMMYVVLEEIFPHSKSVYCIIGFLL
                     GTMIVNYI"
     gene            50023..51063
                     /locus_tag="KNP36_000355"
     CDS             50023..51063
                     /locus_tag="KNP36_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HBF0872252.1"
                     /translation="MKTIISNIDINNIDYEEIKIQAKLLREGKTVIFPTETVYGLGAN
                     ALDENAVKKIYEAKGRPSDNPLIVHIYEKEEVYDLAKDISDKAKLVIEKLWPGPITII
                     LNKKDIIPYKTSGGLDTVAIRMPSNVIARAIIKEAGIPIAAPSANISGRPSPTKAKHV
                     YEEMNGRVDGIVLGGDSNFGLESTVLDLTEETPMILRPGSITKEVLEELLGEVKLDPS
                     LSKKEDNQKAKAPGMKYKHYSPNADVYIISGKRENVATKINDMIKSNRDKGLKTGVMC
                     ISRNREFYDGEVIDLGNSLEEVASNLFDALIEMDKKGVDVIYSEEFPKTGVGQAIMNR
                     LLKSAGYKVIKA"
     gene            51080..51529
                     /locus_tag="KNP36_000356"
     CDS             51080..51529
                     /locus_tag="KNP36_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight protein arginine
                     phosphatase"
                     /protein_id="HBF0872253.1"
                     /translation="MNILIVCTGNTCRSPMAEAILRKAIKESGRSIEEYSISSAGIST
                     ANGMGASENSIEVLKEIGIDLSNHRSKVITKKLIDESDIILTMTKSHKEILVQAVPKC
                     KEKVYTFKGFANKNEEDISDPFGGNLDIYRSTMREIMYSVNEIVKKI"
     gene            51546..51998
                     /gene="rpiB"
                     /locus_tag="KNP36_000357"
     CDS             51546..51998
                     /gene="rpiB"
                     /locus_tag="KNP36_000357"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 5-phosphate isomerase B"
                     /protein_id="HBF0872254.1"
                     /translation="MKIGLGCDHGGYNLKKEIISYLESKGIECVDYGTNNATDSVDYP
                     VYGEIVANSVINKEVDYGILCCGTGIGISLAANKVPGIRCAVVSDVFSAKMSKAHNDA
                     NMLSLGERVLGKGLALEIVEAWINTDFEGDRHARRVNMIKSIEEKHNK"
     gene            52034..52663
                     /gene="upp"
                     /locus_tag="KNP36_000358"
     CDS             52034..52663
                     /gene="upp"
                     /locus_tag="KNP36_000358"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HBF0872255.1"
                     /translation="MSKVVETNHPLIQHKLTLMRDKNTGSKDFRELLTEIAMLMGYEI
                     TKDIPLKDVEIETPIQKTSSKVVAGKKLAIIPILRAGLGMVDGLVSLMPAAKVGHVGL
                     YRDPETLKPVEYYCKLPQDIGERDIIVVDPMLATGGSAVAAIDLLKSKGAKSIKLANL
                     VAAPEGIAEVQKYHDDVDIYVASVDERLNEHGYIIPGLGDAGDRLFGTK"
     gene            52958..53773
                     /locus_tag="KNP36_000359"
     CDS             52958..53773
                     /locus_tag="KNP36_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EF2563 family selenium-dependent molybdenum
                     hydroxylase system protein"
                     /protein_id="HBF0872256.1"
                     /translation="MKNCIVVRGAGDLATAVIHKLHNSGFKVVALEIEEPLAIRRQIS
                     FCEAVYEKKVTVEGVECIFCNTEKEIEEVLSQHKVALIIDPKGEKLSKLNPIVLVDGI
                     LAKKNLGTTKDMAPLTIALGPGFCAGEDVDVVIETMRGHNLGRIITNGRAEKNTGVPG
                     AIKGFSKERVMHSQYDGIMENVCKIGDIVEKGDLLCYINNYEKKHEVRATISGVLRGL
                     LKDGAKVNKNLKILDIDPRKEEVKNAFTISDKARCIAGGVLEAILNNGIYPQN"
     gene            53999..54436
                     /locus_tag="KNP36_000360"
     CDS             53999..54436
                     /locus_tag="KNP36_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dCMP deaminase"
                     /protein_id="HBF0872257.1"
                     /translation="MRPSWDEYFMEIAEVVKKRSTCIRRQVGAVIVRDKQILTTGYNG
                     SPRNLEHCENIGCKRQELNIPSGERHELCRALHAEQNAIIQAAHNGISVDGATLYVTT
                     RPCVLCAKMCINAGILKIVYEGDYPDDMSTELLKEAGIELIKF"
     gene            54621..54848
                     /locus_tag="KNP36_000361"
     CDS             54621..54848
                     /locus_tag="KNP36_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AtpZ/AtpI family protein"
                     /protein_id="HBF0872258.1"
                     /translation="MSKRNTHTEIAKLFSLISQIGLMIVISILGCTFLGKFLDSKLNT
                     TPVLTIIFLLLGVGGAFSGVYKTLIVYTRRK"
     gene            54853..55239
                     /locus_tag="KNP36_000362"
     CDS             54853..55239
                     /locus_tag="KNP36_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase subunit I"
                     /protein_id="HBF0872259.1"
                     /translation="MDIKLLNQVRSVTKGIVIFDVVLIVLMLITSTLSKPVLLGLIFG
                     SIIAMLNFRLLAISLEKSVTFPAGKAQAYASAQYAVRLFIMAVVLIASATVPHLNIIG
                     TALGLLSTKFVILSKNFINKLKRKEA"
     gene            55242..55946
                     /gene="atpB"
                     /locus_tag="KNP36_000363"
     CDS             55242..55946
                     /gene="atpB"
                     /locus_tag="KNP36_000363"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HBF0872260.1"
                     /translation="MNQAHYYLIGNFKISETILVSWGIMAFLAIASYFLTRNLKKVPT
                     SKVQIFLEFAVGGLAKMVTDVMGKNTVKRMPYMIPYIGSLFLFFACSNLSPLLGLRSP
                     TTDLDTTAAWAMITFFMIYFAGVKFKGLSYFKELAQPLAIMLPINIIGELARPISLSF
                     RPFGNILGGTIIMGLFYQLLGFISSLIPGLSIPIGEILIPVPLHLYFDLFAGLLQAYI
                     FIMLTMVFISSAGELD"
     gene            56015..56275
                     /gene="atpE"
                     /locus_tag="KNP36_000364"
     CDS             56015..56275
                     /gene="atpE"
                     /locus_tag="KNP36_000364"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F0 subunit C"
                     /protein_id="HBF0872261.1"
                     /translation="METAIVAAASAIGAGIAVATGIGAGIGQGIAAAKAAEAVGNQPE
                     AKGDITSTLLLGVAIAESSAIYGLVISIILLFVNPFFKYLGM"
     gene            56398..56895
                     /gene="atpF"
                     /locus_tag="KNP36_000365"
     CDS             56398..56895
                     /gene="atpF"
                     /locus_tag="KNP36_000365"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HBF0872262.1"
                     /translation="MEKALVGITWEFVFQIVNTFIIFLLLRKLLFKPVLNIIESREND
                     IKSDLAEGEKAKNEGLALKKEYESKINFAKDEGQEIIKQATIRAEQKSDDIVNTAKKD
                     ALDIKEKANKDIEQERQKVINEIKNDISNIALLAASKVIEKDLDKSKHEELIENFIKE
                     VGEAK"
     gene            56892..57437
                     /locus_tag="KNP36_000366"
     CDS             56892..57437
                     /locus_tag="KNP36_000366"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HBF0872263.1"
                     /translation="MINVIANRYAEALFQLGEEENSTDVLFKELEKVVDMMTKVSKDF
                     YKVLKSPLVSKSEKKNLVEIIFSKEVSSNIKNFLKVLVDKDRISYLEDIELAYKELLN
                     KKNNVIDGVAISAIPMSETDIKELEVKLSNKYNKNVTIENVVDKTILGGVLVRIGNEQ
                     IDGTVKTRLDKMKEKLSEVIS"
     gene            57454..58956
                     /locus_tag="KNP36_000367"
     CDS             57454..58956
                     /locus_tag="KNP36_000367"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003405060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HBF0872264.1"
                     /translation="MNLKPEEISSIIKQQIKNYENKVELTDTGSVLTVGDGIASVYGL
                     EKAMSGELLEFPGEIYGMALNLEEEVVGAVILGDDSEIKEGDIVKRTGRIVEVPVGEA
                     LIGRVVNSLGQPIDGKGPIAYTKTRPVESEAPGIIDRRSVYEPLQTGIKSIDSMIPIG
                     RGQRELIIGDRQTGKTSIVIDTILNQKGKDVICIYVAIGQKRSTIAQLVSSLEKGGAL
                     DYTIVVSATASESAPLQYIAPYAGAAMGEEFMYNGKHVLIVYDDLSKQAVAYREMSLL
                     LRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPIIETQAGDVSAYIPTNV
                     ISITDGQIYLQPELFYSGVRPAVDPGISVSRVGGSAQIKAMKKVAGTLKLAYSQYREL
                     AAFSQFGSDLDEDTKKRLAQGERIVEILKQGEHQPIKVENQVMIIYAVINNHLEDIPI
                     DNIARFESELYAFVDNNYPEISRKILGGEDFTHDLTDAINEFKEKFVVEV"
     gene            58984..59862
                     /gene="atpG"
                     /locus_tag="KNP36_000368"
     CDS             58984..59862
                     /gene="atpG"
                     /locus_tag="KNP36_000368"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F1 subunit gamma"
                     /protein_id="HBF0872265.1"
                     /translation="MAGAGIKAIKTRMGTVESTKQITKAMELVASSKLRKAKEKAEDS
                     REYFNTLYNTVKDIAQTTRGIRNEFLKEREVKNKCYVVVAGDRGLAGGYNSNVLKESV
                     SHMKGKKETVITVGKKAHEFFSKRNYNIAKDINSVEACGYEDATEISQTIIDLYKKGE
                     VDEVYIAYTKFKSALSQEVEILKLLPLVFEKDTDEQGMAVKEEKQNRSKVQYIPSAEA
                     VLSYIVPQFISGTVYGGILESFASEQGARRTAMESATDNANEMLSNLELSYNRARQSA
                     VTQEITEIVGGVEALK"
     gene            59875..61269
                     /gene="atpD"
                     /locus_tag="KNP36_000369"
     CDS             59875..61269
                     /gene="atpD"
                     /locus_tag="KNP36_000369"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HBF0872266.1"
                     /translation="MANVGKVVQIVGAVLDVKFDSEQSLPNLLNALVIKLGDKEIVAE
                     VAQHIGDDTVRCIAMSATDGLVRGMEVVDTGGPISVPVGDETLGRIFNVLGKPVDGKP
                     APKSAPKLPIHRPAPAYDELETTAEILETGIKVVDLLAPYLKGGKIGLFGGAGVGKTV
                     LIQELINNIAKQHGGISVFSGVGERTREGNDLYGEMSESGVINKTALVFGQMNEPPGA
                     RMRVALTGLTMAEHFRDEQGQDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLA
                     TEMGALQERITSTKKGSITSVQAVYVPADDLTDPAPATTFSHLDAKTVLSRQISSLGI
                     YPAVDPLESTSRILDPSIVGKEHYEVARGVQSILQRYKELQDIIAILGMDELSDEDKL
                     IVARARKIQRFLSQSFTVAEQFTGNPGQYVPVKETVRGFKEILEGKHDDLPESAFLFV
                     GTIEDAVRKAKGSM"
     gene            61272..61532
                     /gene="atpC"
                     /locus_tag="KNP36_000370"
     CDS             61272..61532
                     /gene="atpC"
                     /locus_tag="KNP36_000370"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP synthase F1 subunit epsilon"
                     /protein_id="HBF0872267.1"
                     /translation="MASEFSLKVVTPSNTFYDGDVEMIVVRTTKGDKGVLKGHIPFVS
                     GIPVGTLKIKKEGSFKEAKIAEGFINVTQDKTVILTESAEWI"
     gene            61994..62374
                     /locus_tag="KNP36_000371"
     CDS             61994..62374
                     /locus_tag="KNP36_000371"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HBF0872268.1"
                     /translation="MNIFDIGVDIIEIDRIRKAVDKNNRFLEKIFTDREIEYFNSKNF
                     KAESIAGNFAAKEAISKSIGTGIRLFNFKDIEVLRNEMGKPIVKTYNNLAKMCIDYNV
                     LEIKVSISHSKDYAIANAITIIKD"
     gene            62389..62850
                     /locus_tag="KNP36_000372"
     CDS             62389..62850
                     /locus_tag="KNP36_000372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421362.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HBF0872269.1"
                     /translation="MMDKTAKEIMTTDVIVAKQDDSIADVANMLIAEKIGGLPVVDSE
                     NRVVGIISETDILKKEKYIEAPLYINLLQGLIFLDDLKKVEKDIKQVAAYKVGELMSK
                     DIIKVHEDDKFDDVANVMIKKSINRVPVVDDDNKLKGIICRYDIIKALYNE"
     gene            62871..63461
                     /locus_tag="KNP36_000373"
     CDS             62871..63461
                     /locus_tag="KNP36_000373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872270.1"
                     /translation="MRKKWTIVCIMFLALVIIVIGCQKRQSTKEEVYKDFQKQISDMN
                     YYSCKAEVEVVGNKSPHNYVLIHTYKKTDNYKLEVISPKHLKGKSIEYQDDKILVKNP
                     KISDVVELPNTGKNNQYLFVGDFIKNYLQNEEMKVKLSKGHLVLETFIPGDNKYFNKQ
                     VLYVNADTKNPEKMEVLDKEGVPRFTVKYKDFEYRN"
     gene            63476..64633
                     /gene="alr"
                     /locus_tag="KNP36_000374"
     CDS             63476..64633
                     /gene="alr"
                     /locus_tag="KNP36_000374"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HBF0872271.1"
                     /translation="MQKITVPTWAEINLDNLRFNLNNIKNLLEEDIKICGVIKADAYG
                     HGAVEVAKLLEKEKVDYLAVARTAEGIELRQNGITLPILNLGYTPDEAFEDSIKNKIT
                     MTVYSLETAQKINEIAKSLGEKACVHVKIDSGMTRIGFQPNEKSVQEIIELNKLEYID
                     LEGMFTHFATADEVSKEYTYKQANNYKFMSDKLDEAGVKIAIKHVSNSAAIMDCPDLR
                     LNMVRAGIILYGHYPSDDVFKDRLELRPAMKLKSKIGHIKQVEPGVGISYGLKYTTTG
                     KETIATVPIGYADGFTRIQKNPKVLIKGEVFDVVGRICMDQIMVRIDKDIDIKVGDEV
                     ILFGEGEVTAERIAKDLGTINYEVLCMISRRVDRVYMENNELVQINSYLLK"
     gene            64666..64953
                     /locus_tag="KNP36_000375"
     CDS             64666..64953
                     /locus_tag="KNP36_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="HBF0872272.1"
                     /translation="MYDKSKEKIEVTLPDSLISEVDSIVQMENSNREDFAKAAFQFYI
                     TQKKKIHIKESMKTGYREMGQINLSLAELGMTVEEVSSDDKNEGKIAQGEY"
     gene            64922..65305
                     /locus_tag="KNP36_000376"
     CDS             64922..65305
                     /locus_tag="KNP36_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="HBF0872273.1"
                     /translation="MKGRLPKVSTNCEIKRGDLYYADLSPVVGSEQGGVRPVLIIQND
                     VGNKYSPTVIVSAITSQINKAKLPTHVEISSNEYGLNKDSVILLEQIRTIDKKRLREK
                     IGCLDENMMIKVDDGLQISLGLFTF"
     gene            65476..66303
                     /locus_tag="KNP36_000377"
     CDS             65476..66303
                     /locus_tag="KNP36_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HBF0872274.1"
                     /translation="MRDHKGLNEIARIIRRDIVSMIHRAKSGHPGGSLSVVEILTALY
                     FDEMNVDSSNPKMEDRDRFVLSKGHAAPALYATLAEKGYFDKEELNGLRKIGRMLQGH
                     PDMKGTPGVEISTGSLGQGFSVACGMAMASKLDNAPWNVYTLLGDGEVQEGIVWEAAM
                     SAAHYKLDNLIAFLDNNGLQIDGDIESVMSLGSIVDKFKAFGWNVIEIDGHDFDQIFA
                     ALDIAKSTVKKPTMIVAKTIKGKGISFMENQAGWHGTAPSDEELEKALLELGGADNE"
     gene            66296..67237
                     /locus_tag="KNP36_000378"
     CDS             66296..67237
                     /locus_tag="KNP36_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HBF0872275.1"
                     /translation="MSKMATREAYGKALVKLGQINDNVVVLDADLSKSTKTHDFYKSF
                     PDRFFNMGIAEQNLIGAACGLSTAGKIPFASTFAMFATGRAFEIIRNSVCYPKLNVKI
                     CATHAGLTVGEDGASHESVEDIAIMRAIPNMTVLVPADGVETEKIIFEIAKYNGPVYV
                     RLGRSSVPVLFDEDYKFEIGKGTVLREGKDVSIIACGIMVNEALLAQEKLQEEGISAR
                     VINMSSIKPIDKDLILESAKETNAIVTVEEHSIIGGLGSAVSEVVGESCPTIVKKVGI
                     KDTFGESGTPNELLKKYELTCDDIIKTVKEVIIAKRM"
     gene            67660..68754
                     /locus_tag="KNP36_000379"
     CDS             67660..68754
                     /locus_tag="KNP36_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872276.1"
                     /translation="MSEKVNVKTVISFAGAYVATVIGSGFATGQEIMQFFSFYGFAGI
                     IGGIISMVLFSWMGASVMSKGKELQLKEPIKIYRVYCGKYLGIFFEWFGPLFLFGVFV
                     VMISGAGATLTEYYGLNPFVGRVGMAVVALLTVSLGLDKLSKILGGIGPIIIIFTLLV
                     GGISLAKNIGNIGEAAQVLSTVKIAKPVPNAYLSGVIYTTYNTIVVMAFLTGLGASAA
                     NKKEAICGGILGGVALMAAAIMMHLAILSDIGNLYSKAIPSLFLADKISPVIGVLFSI
                     ILILGIYTTAVPLLWSVTNRFVDDKHPKFKLITLIAAILGLIGGFLPFDKLVGILYPY
                     TGYMGVIILVCVLYRQITKTSGYQEGISDK"
     gene            68980..69396
                     /locus_tag="KNP36_000380"
     CDS             68980..69396
                     /locus_tag="KNP36_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872277.1"
                     /translation="MNVKFNIKGIIYGVIALVFVIGGFIFIPSMFVEKSKPIDYTVLQ
                     RNSIPEKILDVMDKYTNEERALAAKIDNKIYIIVTRGNNKYGIEMDKIESVVEEGKDV
                     LRVKIKYKDKEDSFPYIVVETNMSELPDRIELNATK"
     gene            complement(69578..70147)
                     /locus_tag="KNP36_000381"
     CDS             complement(69578..70147)
                     /locus_tag="KNP36_000381"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HBF0872278.1"
                     /translation="MKKEFRKKVIESRKNKSANFVLSNSNLITEKLLQMEDIRNATNI
                     MLYLNFNNEVQTDNLIKKLLSLKKIVSSPITIKENHTLIPTQITDLKEGLRIGAYGIR
                     EPNEKSPTIDIKALDVVIVPAVAYDIHCYRLGYGGGFYDRFLENLRKDAITIGIAFDF
                     QIFDSIPKETHDAQLDYIVTETRIITPNN"
     gene            70301..71458
                     /locus_tag="KNP36_000382"
     CDS             70301..71458
                     /locus_tag="KNP36_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S41 family peptidase"
                     /protein_id="HBF0872279.1"
                     /translation="MYLVISKKKAIFLGVILVIITAMVTSAFQLTLGNKVVISKELYE
                     DYKKYDKLLGLESIIKQDFYKKVSDTDLVNGAAKGLFLGTNDKYSGYYTKDEMENLIN
                     DSEGSYVGVGMYIGASKDGGLVVVPMKDSPAEKAGVKSGDKLVKVNGKSVSYKNSDEA
                     VRMMKGKKGKTVELTILREDKQLNFKVKTDQIIEKSIESKVIDNDLGYIEITQFISST
                     YTDFDKALKELKAKNIKGLVIDLRNNPGGMLDICKEVADELIGEGTIVYTKDNKGNTE
                     YLKSDKEKLGLPIVVLTNGESASAAEILTAAIVDNKEGISVGTTTFGKGLVQSVVRLK
                     DGTGYKLTTAQYFTPNGDYINEKGIKPTIEEKDENKQLDVATKWLREQIDK"
BASE COUNT        28807 a         7596 c        13323 g        21912 t
ORIGIN      
        1 taaaatattg agcgattatt aaaaagatat atatataatt taatttgagc agtttgttat
       61 atattataaa aaaagagaaa aataaaaggt aaattgtttc tggataactt aaaattggaa
      121 gtaagaatat ttaactagag aagaattatt taagtttagg ttagctctag gagtagctga
      181 ttttatagga acaatagatt ttatggatga tgatataaac atggtagcaa ttagaccaga
      241 agatataagg gtagaattta atagagattt caaagaaatt atagacctca aactcagacc
      301 gtatcgatat aaaaactaaa gttagatgat atagtgttgt agataggacc atcagctgtt
      361 atggcagtat tagtgctttt aacaaatata atagtaaaac ttttgtatga attgataata
      421 aaaaaattaa aaaccaagac ataaaaatgg caacaaaaag aagttgaata agggaggtaa
      481 aaatgaaatt taagaagtta gtctctttgg gaatattatc aacactttta ttgagtgtaa
      541 taactggatg tagtaatgtt tcatcaggtt caaacttaaa gtctaataat aagacaaaag
      601 gagagttaac agtttataca gcaattgagg aagatagtat agatacatac ttagctacat
      661 ttaaagagaa atatccagat attaaattga atgtacttag attatcagta ggaggtataa
      721 cagcaagatt attagcagaa aaagataatc ctaaagcaga tgtgttatgg ggtgttgcag
      781 ctacaagttt gataatttta gatgacaaag aaatgctaga gccatacgct ccgaaaggct
      841 ttgataaggt aaattctgca tttaaagatg ataagaaagt tccttcttgg gttggaatag
      901 atgcttggat gactggtata acagtaaata ctaaagaatt aaaagctaaa aatatatcag
      961 ctcctagttc ttatgaagat ttaataaagc cagaatataa agatcttata tctatgccta
     1021 gtccagcttc ttcaggaaca ggatatttaa cagtatcaga actcatacaa attatgggtg
     1081 aagaaaaagc atggcagtat atggataaat tgcataaaaa tattggtgta tacactcagt
     1141 ctggttcagc tccagctata ttagcagctt caggagaata tcccattggt atatcttttg
     1201 gaaatagagg tataaagtta aaaggtgaag gttatccagt agaagtagta tttccaaaag
     1261 aaggttctgg atgggagata gaatcaaatg cacttgtgaa aaaagataat ataaaagaag
     1321 catcaaaagt atttttagat tgggctataa gtaaagatgc aatgaatgag tattctaaga
     1381 attttgcagt tactacaatt gacacgggaa atccggtgcc agaaggattt ccaaagaatc
     1441 cattagaaca gatgatagat aatgatttaa aatcagcagc aagaaataga gaggctatac
     1501 taaataaatg gatagaaaaa tatgatggaa agacagaaaa agagagctaa gccttgcaat
     1561 aaaatttagt acaaaaagcg cctagaatat aagttttata tctaggctct tttgatatat
     1621 ttatttaaaa tgcatatttc tatataaaaa taaatagttt agtaccttga ttaaattaaa
     1681 taaaaacctt aaaataaaga gatgtaaaga aaaactaaaa acgaataaaa ggtgaattta
     1741 tatgataaaa gaaataatag tagtagaggg tagagatgac gttacagcag ttaagagagc
     1801 aatagatgca gaacttataa ctacaggtgg atttggattt ccaaaaggtg taatggagcg
     1861 tataaaagct gctaatgaaa gacgtggtgt tataatattt acagacccag attttgcagg
     1921 tgaaaaaata agaaaaaaaa tagcatcaga agttccagga tgtaaacatg catttctacc
     1981 gagagaggaa gctaaaaagg atggagatat aggtattgag aatgctactc ctcaaagtat
     2041 aatagcagct ctgaataaag ttagaactga aaatacagaa aaaagagatg aatttaagca
     2101 agttgactta attagaaatg gtcttatagg taatgaagaa gcatcactta gaagagatgc
     2161 acttggaaaa atacttggaa ttggatatgg aaatgcaaaa caatttttaa atagattgaa
     2221 taattatgga gttgaaagag aagaatttat agatgcatta aaacaaatct aaacgtaatg
     2281 tttaatgtat gaaaaatatg tatataaaat aaattgtgga attacggtta atttaagatg
     2341 aattatttat aatatacacc ttattttaaa tcaatgtaaa tacatataaa taagtataat
     2401 taataaaatt aaatatcaaa ataagttaaa aaggagtaaa taatggatag actatcttca
     2461 cataatgcaa caaaggaagt agtacaaaaa tataatttta aattttcaaa gtctttaggt
     2521 caaaatttct tgatagatag taatataatt gataaaatct tatctggagc tagaatcaca
     2581 agaggagata atatcataga agtaggacct ggtataggaa ctcttactcg tgagatgggt
     2641 aaaatagcag aaaaagtagt ggctatagaa atcgatagaa atttaattcc tatattgaaa
     2701 gataccttgt cagatttaga taatacagag gttgtaaatc aagatatact aaaagtagac
     2761 atacaggaat tagtaaaaga taaattaaat ggtgggccag ttaagcttgt agcaaatctt
     2821 ccatattata taactactcc aatagttatg aaatttttag aggaagacat acctgtaaca
     2881 gacatagtag tcatggttca aaaagaagtt gcagatagaa tgaatgctat tccgggtact
     2941 aaagattatg gggcattatc tatagctgtt caatactatt gtgatacaga gattgtggca
     3001 aaagctccaa gacatatgtt tataccacaa ccaaatgtag attccacagt tataggtcta
     3061 catgtaagag ataaaagaaa atatgatgtt cataatgaag acatattttt taaaacagta
     3121 aaagcatcct ttggacaaag aagaaaaact cttcttaatt cgttgggagg tcttggtttt
     3181 cttaataaag atgaaataag agaagtatta aaagaagcta atatagacga aaaaagaagg
     3241 ggtgaaactc ttagtataga agagttttca gttctttcaa atataataaa tacaaaagta
     3301 tcttctaaat agaaggtact ttttttaatt ttgttaacat atattgttta gagaaactgt
     3361 gttaaggggg gattgcagtg ggttctaaaa gaaagtttaa aagagactat ataatactag
     3421 aagctaaaga cataaacttt agatacaaag aacgagtact gccaaaagct tttgcaaaag
     3481 ttgaagtaaa tgatgaaaaa gcaattattg cattatatgt agaaaatcta aaatatgtta
     3541 aagatgggta taaagcagta gcaataaaag atgaccatgg attaatagac ttaggaaata
     3601 taattttaaa tgaacaagga agaggtgaat ttgttttaga tttagaagat tatgatgatg
     3661 agataaaagg tattgcatta ttgtatgaaa gaaatatacc tttaattgga tttaaaggaa
     3721 ataagcttga aaattatgag gacatattat ttcaagaggt agaggaagaa gaatatgaag
     3781 aatatgaaga gttggaagaa gaagacgaag agatagagga gaatgaggaa agtgatagag
     3841 acgaagatag tgaagaagaa tatattatag aagaatatga tgaagatgag tatgaagact
     3901 attgggaaga tgatgaagat attgaagaag gagagttaaa agcaagaacg gaagtagaag
     3961 attctgatga tgaggaaata gaagagttca ataattataa ggaaatagaa aattataata
     4021 gggttaaagt acaggaagaa tatatagaca tagaatatga tgaagaagaa gaggaagaag
     4081 aagtttttga agtaaataga gaagaagata ggtttgtttc ctcaaaacct actaaatcaa
     4141 agaaagttca aaaagatcag aataatattg aaaaaataaa aagagctaat ggagtaagtc
     4201 aaggagagag tggaaataaa caaaccagta cattacttat gccaagacaa ataaaaaaag
     4261 gtttgaaatt atttaaagaa gtaaaacctt ttgtaacaga ttatatagat aagacaagat
     4321 ggtggaaaat agagataaat cctacaacac tgtgtggata tacaatgcct tatttaggat
     4381 atttaaacgt attgaattac actatgtata gtgatgcagt tttacattca tataaataca
     4441 gacactattt atttggagtt cagtatgatg aatataataa gagaaaacat tatatttatg
     4501 ctatcccagg aaatagaaat gaacagccag acaatggaag cacaggattt ttaagatatc
     4561 aagcttgtga taatagaaca aatagtttag gatattggct atgttttata gattctagac
     4621 aaagaaatat agttaggtaa aaataataaa aatgaaaaaa tttagactca attcttattt
     4681 tactgaaaaa attaatgaaa tgtagtacaa aactttaaaa actattgata atatttaaat
     4741 attacactac aatatatctt gaaataccta ttatattatg gaggaaaatt atgataaacg
     4801 agcaaagaat tttaaatgag tttcttgaat tagtacagat agatagttta tctttaaaag
     4861 aggggaatgt tgctaaagta ttagttaaaa aattagaaga aataggttgt tcagtagtaa
     4921 tagacaatgc tggtgaaaaa gcaaatggag aaactggtaa tataatagct acattaaaag
     4981 gaaataaaga aggaaagaaa atattattta gttcacatat ggatacagta actccaggta
     5041 taggggtaaa acctatagtg gatgaagcaa atggaataat aaaaagtgat ggtactacaa
     5101 tattaggttc tgatgataaa gcaggtatag cagctatatt agaaggctta agatatataa
     5161 atgaaaataa catagaacat actgatatac aagttgtatt ctctatatgt gaggaatgtg
     5221 gattagttgg agctaaaaat ttagactatg gaaaaataga ttctgaatat gcatttatat
     5281 tagatagtgg tggttctcca ggtgaaataa tagtaaaagc tcctgcacaa gatgtaataa
     5341 atgttaagat attaggaaag actgctcatg caggtcttga acctgaagct ggaataagtg
     5401 ctataatggt agctgccaga gcaatagaaa atatgaattt acttagaata gacgaagaaa
     5461 caactgctaa cataggaatt ataaacggtg gaacagctac aaatatagta acaggagaag
     5521 ttaatatagt tgcagaagcc agaagtctaa aagaaaataa attagatgtt caaactaaac
     5581 acatggtaga gacttttgaa aaagctgcga aagattttgg agctcaaatt gagatagatg
     5641 ttaatagagc atacacacca atagatgtta gtgaggattc tgaaataata aaacttgcaa
     5701 agaaggcttt ttcaaactta ggtatagaag gtcatactga atctacagga ggaggtagtg
     5761 atacaaatat attaagtaag aatggtatcg aagctataac tttaggaatt ggtatgaaaa
     5821 atgctcatac actaagtgaa catatagcta taaaagactt atatgattct gctaaaatgg
     5881 tagtggagat aataaaggaa gcataaattt aaataatagt gtataatata tatatcgcct
     5941 agcttaagct aggtgatttt tcattttata gaagattgat aatctctatt gaaagcaaag
     6001 agtatacatt tgcatataag agagtgttta atttatgttc aaatgtaggt tcttaataat
     6061 atttagattg tttcataagg gaggaataaa tatggaaaca aggtatgaag aagcaaataa
     6121 aataacaata caatcaatac tttggaatat agtattaaca ataattaagg ttatagctgg
     6181 tgttattggt aattctagcg ctatgattgc ggatggatta cattcagcat cagatattat
     6241 aagttctata ggagtactaa taggcaatta tgtatcttct agacctggag atagagagca
     6301 taattatggt catgagaaag cagagacatt agtatcattt gtgttatcaa tattgcttat
     6361 tttcgtttct ataacaatag gtatagaggc aattaaatct ttatttaact tagatgcatt
     6421 aagtgttcca tcaatattac cattagtagt atcagttatt tcaatcctga taaaagagta
     6481 tcaatataga ataacaataa aagttgctaa aaagataaat tcaccagccc taaaagctga
     6541 tgcttggcat cacaggtcag atgctttatc ttcagtagct gcttttatag gtataggtgg
     6601 ttctatttta gggtttaaac cattagaccc aattgcgtca gttgtagtgg ctatatttgt
     6661 agctaaagta ggaattagta tacttataag ttctgttaat gaattgatgg atgtttcagt
     6721 tgatgaagaa gagataaaag aattaaaatt tattgtagca gatacagaag gtgttaaaaa
     6781 tcttggtgat ataaagacta gaaaacatgg agctatggca tatgtagatt tgactatatg
     6841 tgtggatgaa aatttgacag ttaagcaagg tcatgatatt gctaccaagc ttgaaaaaca
     6901 tataataaaa catatggaat ttgtaaaagg tataacagtt cacgttgaac catgtactaa
     6961 ttgccaagga aataagtgta ataattaatt aaaacttaaa aaaaagtgta aaaagttata
     7021 taattgtttt atgattataa actctagggg tggttaaatg agcaagaaaa gaaaactaaa
     7081 gaaaaaagct gcaatattaa taggagtagt tgttttcttt ataatatact ttatatcctt
     7141 tagaatagga ataaatatgg aaaaggataa aagtgaagtg ccaaagaagg tagaaaaaga
     7201 agaagaagat aataggtctt taaggactca aataaaagag aagaagaagg tttatatatc
     7261 agataaaaat atagaaaaca taaaaattga agaagatatg tgggatgaaa taaagttatt
     7321 tttctcagat tttaagaaag taagaaatac tacttcttct tacgaagcag tttatgaagg
     7381 ttattctgat gatggagtta aattttctac tgaccttaac ttttttagag tatatactgt
     7441 aaataaagaa gaatattata aagtaccagt tagttctaag gatgctttta agaaactttt
     7501 agatgagagt atatatactt cgtttgacct tttaagtcat tataaagatt ggaaagaggt
     7561 tactataact catggaaaag aaattaaaaa agttcataga tggaaatttg atgatttagc
     7621 acataagatg atttcaaaga gggttgtagg aaaagttcaa cctgagaaaa gtaaggaaag
     7681 aagtgactat aattttacta taaatataaa aggtgataat tttgatgtaa aagttgatac
     7741 aatgggaaaa gattatgtaa aagttacttc taagaaaaat gtatcttact atgaggttca
     7801 tacaagttta tttgattacc ttaaaaatga gatatttgaa attggaaaga aataagactt
     7861 taagaaggct atcaaattag atatttgata gcctaaatta ttttatatat tatttttcaa
     7921 ccaacaagtc tgcaacctta taaattggac cagcaccagc agttattact aaatcattat
     7981 ccttaacatt ttcacgtaag tattttacta tatcttcaaa ttcttttata tagatggcat
     8041 ctacattgtt ttgatataat ttctcaacca agtccttaga atgtatatct cctgggtctt
     8101 tttccctagc agcatatata tctgttatga taactttatc agcagcatag aatgcctctg
     8161 aaaattcacc taaaagagat tttgttctag tataagtatg tggctggaag atacaccata
     8221 aagttgattt ttttaatttt ttggcagcag ctaaagttgc ttttaactca gttggatgat
     8281 gtgcataatc atctactact aaagcattct tatagtaccc tttagtttca aatcttcttc
     8341 cgacaccttt ataaattttt atattttttc ttatagtctc taagtcaata ccagaaacaa
     8401 gagctgccat tatggcagaa gaagcattgt atatgttatg aagaccatat acagaaagtt
     8461 caaattctcc taaatctctt ccttcatatt ctattctaaa tattccatga ccactattgt
     8521 caaagtgaat atcttttatt acagcatcat tgtcagaatc tctgccgtat tttataatag
     8581 tagctttaac atcatacaat atgtcatcaa tattttcatc atcgccattt attatgaaat
     8641 agccttctgg gggtaataat tttccaaatt tgttaaaaga agccttgatt tcatctattc
     8701 cagagaaata atcaagatgg tcttcttcaa catttaaaac tatagatatc tttgggttaa
     8761 aattaaggaa actatctaca tattcacatg cttcagttat aaagtggttg gaattaccta
     8821 tcttaacatt accacctatc atacttaagt taccaccaac tagtatagtt gggtctaagt
     8881 ctgcatattc aaagattgta gataacatag atgttgtaga agtttttcca tgtgttccag
     8941 aaactgctat agaattttta tattccctca tgatttggcc taaaaaagtt gctctgttca
     9001 ttaccaattt atttttttct ttagcagcca caagttcttc attgtctgga tgaactgctg
     9061 ctgtataaac aaccatattt acatcatctg atatattatc ttttttctga ccaatataaa
     9121 tagttgcccc ttggtcccta agtttgtcta ataggtatga ttcgtttgaa tccgaacctg
     9181 aaacttgata acctttattg atacatattt cagctaatgc actcatgctg ataccgccaa
     9241 ttcctataaa gtgtatattc ataataaaac cacctttctt tttaattaag tcctacaata
     9301 tgaactattt ctgtggtata ataatataat gttcaatatt ttataattaa tatgcatata
     9361 atattatatg tattttattt ttgaatataa taaaacataa gtaatattat accacaataa
     9421 gaattgttat gcattagtta gtttaacgtt atataaaggt acttgtagga ggaaataata
     9481 atgaaattta aaagaacaga gagaattgga gcaatagtta aaatactgtc tgataatcca
     9541 aataaaatat atactttaag ttattttaca aatcaattta atgcagcaaa atcaacaata
     9601 agtgaagatt tattagttgt aaaaaatgta tttgagaagc tacatttagg taaagttata
     9661 actatttcag gagcagcagg aggagtaaaa tatataccta aaacttctat agcagaaaat
     9721 gcagagttct taatggaatt atgcgagaga atatgtgaca agtctagaat actatctggt
     9781 ggttttttat acttgattga cctaatttac gaccctacaa tagctgctaa gataggaaag
     9841 atattcgcat caaatattga gtatgtagat gcagattatg ttgtgacaat ggaaacaaaa
     9901 ggtataccta tggcacttat gactgcaaaa gctatgaatt tacctctagt tataataaga
     9961 aaagatataa aggtatcaga aggtcctaca cttagcatga catatgtgag tggaaacagt
    10021 tctaaagttg aaagtatgag tttgccaaga aaagctctta aaccagatag taaagttata
    10081 attatagatg atttcatgag gggtggaggt actataaaag gaatggtaga ccttatgaat
    10141 gaatttggtg cagaggttat aggtactgga gtattcatat ctacaacgaa tccttcagaa
    10201 aaaatggtaa aagattatat ttcattgatt caattggatg ttaatggaga taaaatagta
    10261 gtagaaccaa acttaaagac ttttaaagat gaatatagaa atgaagattt agacgaagaa
    10321 gaagattcag aatttgaatt tgagatagat gaagattaat aaaaaaaata tttagaaaaa
    10381 tatgtaaaaa taaaaagagg atatccctag ttgttcatag aattatttaa aaaacagttt
    10441 atattaattt attccagcga taataatttt aatataaatt aatttctgtc aaaatcaaag
    10501 ggggatattt tggtatgaag ataactgacg taagagtaag aaaattaaca gaagaaggta
    10561 agatgaaatg tatagtttca ataactttcg ataatttgtt tgtagtgcat gatataaaag
    10621 ttatagaagg ccataatggg ctatttatag caatgcctag cagaaaagta ggcgaaggaa
    10681 atttcagaga tatagctcat ccaataaatg cagaaatgag acaagtttta gaagatgcag
    10741 ttttacaagc gtatcatgaa gcattagttc aatgggaagt agctgctgaa taataataaa
    10801 tatataaaat ggagagagcc cgaacattta ggctcttttt aaatgtagaa tttctattaa
    10861 aatatgtact ttttagtaaa aaagtgctat attattagtg ataatgtata tgttgtatac
    10921 aaattgttag ataaatgtat tataatgtat attgattaag agaataatac gaataaaatt
    10981 aaattagatt gaatggagtg tatcaatgaa ctttaaagct ataatccttg ctgctggcaa
    11041 aggaacaaga atgaagtcta aatacccaaa agttatacat aaagtatgtg gaaaagaaat
    11101 ggttaaccat attatagatg tttcaaaaaa atcaggggta aaagatactg tcgtgatttt
    11161 aggacatgaa gctgatgtag ttaaagaaaa gcttgcagaa gaaattataa tagccatgca
    11221 aacagaacaa cttgggacag gacatgctgt aaagatggct aaagaatata ttaatgatga
    11281 agatacaata gttgtacttt gtggagatac tccacttata aaagaagaga cactaaagag
    11341 actatttgaa tatcatatag aaaataaata tcatgctaca gttcttacaa caagagttgg
    11401 aaatccaaca ggttatggta gaataataag agataagaag ggtgaccttc ttaaaatagt
    11461 ggaacaaaaa gatgcaaatt cagaagaaaa gatgataagt gagataaact ctggaattta
    11521 ttgttttaat ggaaagagtc ttagagaagc actagatttg ctaaataata acaattcaca
    11581 aggtgaatat tatttaactg atactgctaa aataatgaga gataaaggat taaaagttgg
    11641 tgcatttgca ggttcaacta ttgaagaact tatgggcgtt aattcaagag tagaattatc
    11701 aaaggcagaa gaaattatga gacgaagaat aaatgaatct catatggtaa atggagtaac
    11761 tataatagac actaactcta cctatataga atctgatgtt atgataggca atgatactat
    11821 aatatatcca ggtgttatgt tacaaggaaa aacaaggata ggttcagatt gtataattgg
    11881 aatgaattca tctataacaa attcagaaat aggtgatggt acagaaataa aaaattcaac
    11941 tataattgat agtaaggttg gagaaaattc tactgttggg ccatatgcat acttaagacc
    12001 aaagagtgac ttaggaaata atgtaaaaat aggcgatttt gtagaagtaa aaaatgctat
    12061 tatagaagat ggctcaaaag catctcacct ttcttatata ggagatgcac atgtcggtaa
    12121 aaatgtaaat attggatgtg gagtagtatt tgtaaactat gatggtaaaa ataaatttaa
    12181 atcaatagta aaagacaatg cgtttatagg ttcaaattct aatttagttg caccagtagt
    12241 tgtagaagaa aaaggatata tagcaacagg ttcaacaata acacatgatg tcccagatgg
    12301 tgctttggca atagcaagag aaagacaagt tatcaaagaa ggatgggtag aaaaaaagaa
    12361 tcaaaaagac gaccaaagta agtaattatg tagtttatta ttttggctaa aaaatttagc
    12421 tcgaaattat tataaattat attcattagt attttaaaat tttcaggagg gttacataaa
    12481 tgaatactag cggaagcgag attaaaatta ttgcaggtaa ttcatcgaaa gagttagcac
    12541 aaaaaatagc tgactatata ggtgtatcag tactagattg tgaagtaggt acatttagtg
    12601 atggtgaaat atgtgtaaac atgaatgaga cagtaagagg ttgtgatgtg tttgtagtgc
    12661 aatctactaa cagcccagta aatgataact taatggagtt attaatctta attgatgcgt
    12721 taaagagagc atcagcaggt agaataacag cagttattcc ttactatgga tatgcaagac
    12781 aagacagaaa ggctaaggca agagatccaa tcactgctaa attagttgca aatttaataa
    12841 ctgctgctgg agcagataga gtattaacaa tggatttaca tgcagctcaa atacaaggat
    12901 attttgatat accattagac cacttactag gtggaacaat attagcaaat tattttaatg
    12961 aaaagaaaat agaagattta gtagtagtat ctcctgactt aggaagtgtt actagatcaa
    13021 gaaaatttgc taatacttta aatggagaag ttccaatagc tataatagat aaaagaagac
    13081 cgaaagctaa tgtatgtgaa gttatgaact taataggtga tgttaaaggt aaaaatgtta
    13141 tactattaga cgatatgata gatacagcag gaacaatagt taatgctgca aatgcactta
    13201 aagagtttgg agcaaaagat gtttatgctt gttgtactca tggtgtgtta tcaggtccag
    13261 ctattgaaag aattgctaat tcagaaataa gtgagttaat agttcttgat actatacaac
    13321 ttcctgaaga gaaaagaata gataagataa agataaaaac agtagctcct ttatttggag
    13381 atgctataag aatgatattc tctaatgaat cagtaagtaa attattctaa tttattgtat
    13441 ttatgagagt tgtttaaaag gatataaacc ttttgagcaa ctcttttttg attttatact
    13501 tatggaatgt tatttttttc ttgttagaaa ggtatatatt attgtaaaaa gagattatag
    13561 tttaaaatta tgtatattta agtaaaataa acctaataaa gggtatatta ttcaaaatat
    13621 tatgaatata aaaaatatta caaaaaagta ttgaaaaaat tcagattatg tagtattatg
    13681 taaatataaa taaagaaaga ggtgtttcca atgggaaggt tagaagatga acccctaata
    13741 attaaatgat tcagtcacaa tctaaagtga atataaaaat ctattgaaag tttatttata
    13801 agaattgaaa atagtatcta ttctatcttt agtgtttgtg agagggttct ggattatata
    13861 agattactgt aaagagtaat tttgcacaat aagcatatct gtaaatgaag agtttcgttt
    13921 atataatgat tgtggctgaa tcataactat aatagataga atgtttataa tagatgattt
    13981 tataaaatac tatattgtaa tagcttttag ctttcaaata aatattagca aaggatggaa
    14041 atgacaatga taaaactaaa tgataattta taaatatctc cttacgatat ataataattg
    14101 tagggagatg tttctttttt tgtatagcat aatttttcta gaaattctgt ttcaatatgt
    14161 aaaaagttgg tatatataaa tagtataaac agtgttgcta aaatatggta gatattatat
    14221 aatataagtg gatatgtata tacattatga gttatataat ttgaatttaa taaaatagaa
    14281 acgttgattt atgttctgta atgtgggcac cttggagcat attgagttag tggtgcaacc
    14341 ggctatgaaa ttgtatttat ttataaatac tattattttc atagcttttt ttatttaaaa
    14401 aatggttata tgttagaaat aaatttggtt agtacgttta aataatttta cttagatttt
    14461 taaccagata tattgtaagt aagtattaat taaaaaattt aagggggaat aaaaatgaag
    14521 ttaaaaaaga ataaaaaagg tttcacttta gtggaattat tggtagtaat tgcaattata
    14581 ggtatattag cagtagtggc agttccagct ttatttagta atataaacaa ggctaaggta
    14641 gcaagtgttg agtctgatta tagttcagtt aagagtgcag cattatctta ttattcagat
    14701 actaataaga taccagttac accagatggt caaactggtt taagtgtttt agagacttat
    14761 atggagtctc tgcctgataa agctgatata ggtggaaaat ataaattgat taaagttggt
    14821 aataaattgg tattacagat aggtacaaat actgaaggag ttacattaac agaggcacaa
    14881 tcagcaaagt tattgagtga tataggtgaa aataaaatat atacaagcgc tacaacaaat
    14941 agtttgggaa atccattaac aagtaataca aaaatagata ataacgttct atatatagta
    15001 cttatagata atactgtgat ggacacaaca aaatagttaa aacaatattt ttataaaaat
    15061 attgtaaatt taatgaaaaa tataatataa aagacaggaa gaaaatcttc ctgttttttt
    15121 atactatttt ctttaatgtt caattatgaa tgatgatata attgagatag taaaggagtg
    15181 aaacctgtgg ctaaaaaagt tagaatagga gacaaactgg tcgaaaaagg atatataaca
    15241 gaagaacagc ttaaatgggc actatcagaa caaaaaaaca gtggaaaaag actaggagaa
    15301 tttctagtac aagaagggct tatagatagt aacttactaa taagtgtatt aaaagaactc
    15361 ttggatatag aaagtatatt tttagaaggg acagaaatag acactttagc tacaaaaatg
    15421 gttccagaaa atatatgcaa aagatatact gtatttccat ttaaaattga tggaaataaa
    15481 atatgtctag ccatgtcaga cccacaagat agagaagcag ttcaagatgt aaggcgtatg
    15541 tctggtaaag acgtagagat atttatatca agtacagaag atataaacaa agcaataggt
    15601 catgcttatg cacattcaga aataaataag gcaatgactg agtacaacaa aaatagaact
    15661 ggtggagtaa gagaaacagt aatacttgaa gaagatgtaa atgctgctcc aatagtacga
    15721 ttagtaaata acatactaga aaatgctgtt agaatggaag caagtgatat acatatagaa
    15781 caaagtgaaa attacatgcg tgttaggttt aggatagatg gaatgttaag agaatatatg
    15841 aggatgaact cagcaccata taaggcagta atcagccgta tcaagataat gtcagatata
    15901 aatatatctg aaaagagaat accacaggat ggtagaatct atttaaaagt agataataaa
    15961 cccatagatt ttagggtttc tacaatgcca actaacaggg atgaaaagat agctatgaga
    16021 gttcttgata agagtaattt tatggttagt aaagaagtac taggaataga cgaacatggc
    16081 tctaagatat atgatgaatt gataaacact ccttatggtc ttatattggt tgttggccct
    16141 actggaagtg gtaaaaccac tacattgtat tcaatgttaa atcaactaaa tacagaaaat
    16201 agaaatctat taacaataga agaccctata gagtatgaat tacctggtgt aaatcaatct
    16261 caaataaatg aaaaggcagg gcttactttc gccagcggac ttagagcttt tatgcgtcaa
    16321 gacccagata taataatggt tggagagata agagatactg agacagcaga aatagcaatt
    16381 agagcttctc ttacaggaca tttagtttta agtacattac atgcaaatac agcagttgga
    16441 gcaatttcac gtcttttaga tatggatgtg gaaagttttt taataacttc atctgtttta
    16501 ggtgtaatat ctcaaagact tacacgaaaa atatgtgagc attgtaaggt ttcatatgaa
    16561 gcagatattg gagaaaaaaa ggctcttggt attgatgtaa atgaatcagt aactatttat
    16621 agaggaaaag gttgtgaaag gtgtaataat actggatata aaggacgtct aggtatattt
    16681 gaaatgcttg aaattactcc agaaataaaa gagttaatag attcatctgc aaatcaaaga
    16741 gaaattttaa agatggctag aaaacaaggt atggttagct taaaagagga tatagttaaa
    16801 aaagttttaa atggaaagac aacagtagaa gaaatgatta gaataatttt gatgactgat
    16861 taaaggatga tattatgaaa agttttaaat acacagtaat aaaagaggac ggaaaaaagc
    16921 aaactgatgt gattgaagcc aacgatttta atgaagctag aaatcttctt agaaagagaa
    16981 atcttagagt tattgaaatc aaagaaagca aaaataaaaa tataagatta tctagtagaa
    17041 agagaaaaaa agacttagga gctgaccaga taagccactt ttgtagacag tttgctatta
    17101 tagtatcttc tggtataaat agtatttctg gattagaaac attagctaga aggtcaacta
    17161 acattacatt aagagaagaa attaatcgta tagtggcaga aataaaagta ggttctacta
    17221 ttgcagattc aatgctttca tcaaaatcaa agtttccaaa gttacttggt gctatggtag
    17281 ctacaggtga agctacaggt aaattagatg aagtattaaa aagtatggct tcattttatg
    17341 caagtgaaca cagggttaaa caaaagctta gaaatgctgc aacatatcca ttaatagttt
    17401 tgatttcttc atttataatg atttttatat ttacaacatt tatggtgcct aagatgatta
    17461 attcaattac aacagtagga gcaactcttc cacttataac aagaattgtt atggggtttg
    17521 gtatgtttat gaagaagttt tggataatag tacttttagt tattatatta tttatctatc
    17581 agtttaaaaa atatctaaaa acgtcagttg gaagggctca taaagataga gttataaata
    17641 agatacctgt tttaggaaaa ggaataaatt gtatggtagc tacacgattt tcaagagcat
    17701 tgtatctatt tgtatcaaca ggatacccat tagttcaagg gcttgattat attatagata
    17761 gtgtaaataa caccatggca gagaagattt tagcatcagc taaagatgga ataacaagag
    17821 gagaaggctt agcagaaaat ttagagagat atacgtattt tgactctgtg ttggtacaga
    17881 tgatagctat aggggagcag acaggggaat tagagaatat aagtagacag atggcagaat
    17941 tttatgagta tgaatccgag atttatttaa ataggatggc ctcaatgata gagcctgttt
    18001 taataattgc agttggtatt atagttgcga tactggttgt atcaatattc atgccaatgc
    18061 ttagtatata tgatgccatg taggagggaa aggacaaatg aacaaggttt atgtatcata
    18121 ttatggcgat tctatttcca tagttgaggg cagatataaa cacgataagg ataagtttta
    18181 tgtaaaaaat tttaatgtgt tttcaataga ggatattgca caagattttt ctaaggaaaa
    18241 gtatgctcta ttgagatacg cattagaaaa tgttaagtta aaatcaagac atgtagtttt
    18301 ttgtttaaat acaagagatg taattttaaa accccaaaaa cttcctaata tggacaaaaa
    18361 ggatttagac ggatttatga agctagagat ggacgaaatg atggctttgg agtcagatga
    18421 atatgtattt tcgtatgaag tatctagtga aacacctgat aattcagatg gcgatgaatc
    18481 aagtttaaat cttattattg gagctataca aaaggaagag gtaaatgcaa ttgtagagat
    18541 aatgcatgaa tttgatttag tattagatag aatagataca ttatcaacag cttacttaag
    18601 aatgcttaaa aatttagact acaatgatat aatggtaacc aatataagtg acaatagcac
    18661 aattataaat atatataaga aagatacttt atttattagt gataatatac ctataaagat
    18721 aactgctaaa gatatggaca tgcaattatt aaatgtagta gaagaatcaa aaggtcttat
    18781 gaattactat tcgtcaagaa actttggtaa ggttacggat actatattaa tattaggaaa
    18841 aagatattcc aataaattaa tttatgaaac ttttagctct gcattttcaa gctatgtttc
    18901 tcaaggcctt actgagataa tggatatatc tgatatgata actggagata tagatgaaga
    18961 tgatataaat tcaattgtag agcttttagg aagtatgata gaacctaaag ggaaaagaga
    19021 ttttgaaaat ataaactttt taccaatgga tatacttaga aaacagataa aagctaaaca
    19081 aatgaaaaac atactgaaaa ttgctccaat agttattttg attcttgcta taccttattt
    19141 atgtttaatt ttttcaaata atttagcaaa taaggaactt gaaaatgtta atggtgaaat
    19201 aagaaatatt gaatctgcat attatcagat tggaaatata gaaaaaatga tacagagtaa
    19261 aagcgaagaa ataaaggtat atgatatgtt aattgggaaa aaggtaaagt gggaaaattt
    19321 attggatgat atagataaaa atactccaag taaagttgaa ctaacaagtt tatcaacaac
    19381 ttatcaaaat cttggaacta ataataaagc tgataattca aaaagtaata agactacaac
    19441 agataaatca agtaacaatg aaacaaaatc aagtacgaaa agtgatagta atggagataa
    19501 aacagataat gatttaaatg aagataagac tacaaatgtg tcagaagcat taactggaaa
    19561 tagtgagact aatagtaata acacagataa agatgataaa actccattgt atgataagat
    19621 accaaatgtt ataaatatag aaggaaatgc taaagattcc tcttatgtag gtcaattttt
    19681 atataaatta aagggattat actatttcaa ggatgttaaa ttacatagca taaaaagtaa
    19741 tgcagaagat tctaactata catttagtat gacattatac ctgaaagaag gtgtattaac
    19801 taatgaataa agatatattt aaaaaagata taaaagatat atttaaaatg gaagttagtc
    19861 taaaagggat tcttataaag gttataattt tattagctat tttatcatat ggttattttg
    19921 gactttaccc tcaatatcag aaatatattg ctacaaaaaa ttctgtaaaa caggctactg
    19981 aaaaattaaa tatatataaa gagaaaactg cacttatgcc aaaatatgaa aaacaacttg
    20041 aagaagttga aagtgaatta aaagaaaaaa gcaaaaatct tttatatgat atgcaagatg
    20101 gtcttttttt aataggttta gataaaaaaa tgaaggctta taatattgac ttaaccagtt
    20161 atgacgttgg aaatgttaaa gaatacgaac atttttatgg tatatcaaca acaataagtg
    20221 ttagaggtga ttatagaaat gtcaaaaaat taatggctta tttagaagaa caaaaaaatg
    20281 ttactcaaat actagattat acaatgactt catatataga accagaaaaa gaagaggaag
    20341 aaacaacaaa caataaggat ttaattaaaa atgtgaacat aaataaagat acaaaaatat
    20401 actgggtgga aggcgaaaat aagtggcatt tatataagga ttgtccattg ataaaagagg
    20461 gagagattct aaaaaatgac aaacttttag ataggtctac taattatcta tgtaatactt
    20521 gtgtacttag agctgcaaca gaaaaagaag caaaaaaaga agtcgtagct ccaaaggcag
    20581 aaggtgtagt agatgctaca tttaaattta taatgtacac taaagagaat actacaatga
    20641 tacttgatac agataatcca tcttcatgga gaccaggaaa atataatcca tttaagtcta
    20701 gtgcgaaata aagctaagta agctttaaag ataggtgatg agtttgtaca aaaataatga
    20761 aaaaggtctt actttattag aagtaataat agctgttttt atactgacaa tagttttaag
    20821 tatttcttat aaagtgttca atggtataac atcagcagta aaaaagcaac agattattac
    20881 agatgctcaa gtaaatatta atctaattaa taagtatcta aatagagatt tggaaaactg
    20941 taaagaacta actaaaactg gttcaggtaa taattatgaa tacaatatag agatgccaga
    21001 taatgttgta aaatatgaag tttctataga aactaaaaaa aatacagagg tatattctgt
    21061 aacgagaatc caaaacaata caattgatac agaaaatgaa gttagagaag agataatcta
    21121 taatcaacca ctagttcaaa acaataaaga aatgaaggaa acaccattta aaatagaaaa
    21181 gcaaactggt aaatctattt atactgtaag tatatactat aatgaatcag tgcaagaaag
    21241 tcataaaaat agcaatttaa ataacaaaac ttatacattt gatgttatgt caagaatagg
    21301 ataataagaa tttattaaaa aataagtagg ttgataaaat atgagtaaaa agaatagtga
    21361 aagaggattt tccttaattg aagtgttagt agctatggct attatgggaa ttgtactatt
    21421 tgcatttttt aatattatca atactaataa caaagcaaac actaaaaatg acacagatat
    21481 aacttcctta aactatgtcc aaagtgaaat agaaaatcta agagaaaaga taaaaagtgg
    21541 agaatttgat tttgatagtt tagataaact agaagatgga actgtcgtat atgaaaaatt
    21601 aatagataaa tcaaaaaaag ttgtatatga taaagttctt agtgaaggtg atgtgagctt
    21661 atatgatact ccatatgaaa agattacaac aataaaagat gaagatggta atttaatcga
    21721 caaaggaaat attacaaata agataaagac tattgtagaa gataaaagtg gtcagatata
    21781 taaaatagct gtaactggga aaagcatgaa tgactattca agtaaaaaag aggttaaaat
    21841 tgtaactgaa atatttaaag ataaataatt ttacttgggg gtgagatttt gaggaagtgg
    21901 aataaattta aaagtgaaag aggggcagct ttagttttag ttttggttgt agtagcattg
    21961 ctttctattg ttggattgat attttcaaat cagatagcta atagaataaa atctacaaag
    22021 actactaatg aaggtataca agcaaagtat ttagcagaga catgtgtgga aaatagtatt
    22081 gataaagcat atgaaaaatt gtatgatgag cttgagaaaa tggataatga gtttaaaagt
    22141 gaaaatcaag aaaaatccat atctaggtca aaattaagag atatatcaga tgaagatttt
    22201 aataatcaag atgaggaaaa tattgaagca gaaagacttg gatatatgaa taatataaat
    22261 ttctatttaa ataaagcttc ttcagacttg gaaaaagcta gtatggaatt gaaaaagcta
    22321 tatgatttat atatgttgga ctatagagac attgaatatg tagatgcaaa tattatttca
    22381 catagagatt ctatcttaga aatttgcaag aattatactt ctggagatat tagtaaaata
    22441 aatgaatata ttctgaaaga agatatagac tcaactacat tgattgaggc aaagttagtg
    22501 aataatgata ttcttttaaa aatgttttta gaagaaaata aaattgaaaa tgaacattta
    22561 aattcagcct tttcacatac ttataaggca ttagataaca tttctttggc gatgcaaaat
    22621 atgattgagt atagacatac gtttcatata gatgagccaa aagtagaagt atctaatggg
    22681 attccagatt ctcaacaata ttatgaacta atacaaaatc ctataataaa tagtatggag
    22741 tatatctgga atagtaaatg ggatacatta gaaaaactat tggaaatttt accaaatcaa
    22801 actcaaggat ttaattcttt aagagttcat ttgagaaata atgtaagaaa atttgagaag
    22861 ttaagcgata atatatctag tggtaaaaaa aatacagcaa aaaatttctt aaagtataaa
    22921 gagttattgt atgaaatatc agaccaatgt aatcaactaa aaagtatgtc ttatgagaaa
    22981 atacctgtta aatatgataa catggctttg ataacaactt ttgactatat acaaaatgag
    23041 cttttagcag agataaaatg cagattaaaa gaattaaaac cacaagaaat tgataaaaca
    23101 gaaggtatta ctataaaaat acctttttat aaggctgact acgacatgac aaaagaagga
    23161 tggcctaaat taaaagaaaa tggttcaggg gcggagttaa gcttaatggt aactggtgat
    23221 aaagatggaa taaaagaagt agaagttaca gatggtaaaa aaaatattat tggtttaggt
    23281 gttgaagaaa attcaaattc aaagtataag gttgacgcca ttgtaaactt taatctaaat
    23341 atagatacaa atgtagttgg aaattatgat ataaaagata aaattttgat taatcatgat
    23401 ataagttcat acaaaaaagt aaactaaata taagaagcaa cttagtataa ataaataata
    23461 aaataatttt attatttact actaaaaaaa taagtaaact aatagaagat atggagagta
    23521 aatattatgt atatttatga tttattagag caaggtataa gactaaacgc atcagatata
    23581 cacataacag ttggaacaaa tcctgtagct agagtaaaag gtggatttgt aaaactaagt
    23641 gaacaaatat tgacatcaga agtaacaatg caaatggcaa aagacatagc aggggaatct
    23701 atgtttaaag taatagaaga acatggagaa gctgattttt cagcttcttt aaaaacagga
    23761 gaaagattta gggtaaatgc atataggcaa aaaggaaatt acgcaatagc aataaggact
    23821 ataacagcag aaattccaac atttgaaaaa ttaggccttc cagagagtat aaaatctttt
    23881 actgaaaagc ataaaggatt agttttagtt acaggtccaa caggaagtgg taaaagtaca
    23941 acacttgcaa gtatgataaa tataataaat gaaaaacaac aaaaacatat aattacactt
    24001 gaagacccga tagaatatgt acatcatcat aaacaaagtt tagtaaatca aagagaagta
    24061 ggaactgata cagaaagttt tcattcagcc cttagagcta ttttgcgtca ggacccagat
    24121 gtaatactaa taggagagat gagagaccct gaaactgttt caatagcatt aacagcagca
    24181 gaaacaggtc atttagtatt ttcaacacta catacagtgg gggcagctaa gacaattgat
    24241 agaatagtag acatgtttca accatcccaa cagcaacaaa taaaaacaca gttatctaca
    24301 gtttgtgaag gtgtggtatc acagcagtta cttcctacag cagatgggaa aggcagaata
    24361 gcagcaattg aattgatgtt tgctactcca gcaataaaaa acctgataag ggaaggcaaa
    24421 acatatcaaa ttccaaacat gatacaaact ggagttaaag taggtatgaa aactatggac
    24481 caagatttaa tggaacttta taaaaatgga aagattacaa aagatatggc acttagtagg
    24541 tgtactgacc aagagtttat gacaagaatg ataggtggag taaactacaa tggatattat
    24601 aatcgttaat ctatatgtat ttatggtggg tatagtgttt ggaagtttct ttaacgtctg
    24661 tatttttagg attccagaag gtatatctat ttctagacct ccttctcatt gtatgagttg
    24721 taatactaga ctaaagccaa tagacttaat accagtgtta agctatttaa tgagtggcag
    24781 aaagtgtaga tattgttatg agaaaatttc tagtagatat gctatagtgg aattaattac
    24841 aggactttta tttttaacag tatttatgtt atatggaata tctacatcaa ctatttatta
    24901 tttggttctt gtgtctttac tgattataat tacatttata gatattgacc actttataat
    24961 accagataaa atattggttt ttggagctat attttctatg atttttaacc ttttatttaa
    25021 agaaattcca gttaaggatt caattctagg tgtttttatt tgtggaggaa gtgtctggat
    25081 tatagttctt ttgattgaat ttgtaataaa aaaagagtgt atgggtggag gagatatcaa
    25141 actatttgca atgctaggtt tttacatggg tgttaaaaat ggtcttttga cagccttact
    25201 aagcgtttat gtgggagcag tctatggaat ctgtgtaata attataagta gaataaaagg
    25261 aaaggaatat aattctgtta taccatatgg accttttata tctattggag cattaataac
    25321 aatcttatgt ggaaagcaat tacttgaact ttatttttct atggttatat agatgatagt
    25381 caagttaaat aaagttttaa tttaaaaaaa tgaattaaag tatttaataa ggacaatatt
    25441 attattaacc ctattactaa agtgctacaa actatggagt atataataat aatttcctta
    25501 ttttttgcac atttgataaa taaatctcta tgtgtttttt gtgatagaga aaagaaaaat
    25561 ttatacaata cgttttttat ttacataata actgtagttt tatctgtatt aatatatcta
    25621 aaatttggga ttagtgtaga atgtgtacaa tatatggttt taattccatt tttaataatt
    25681 atatccattg tagattacta cacaatatat gtatatgata taacaatagt tagtggtata
    25741 atagttcaag gtataatttt tttggtcttt ttcaatatag ttcaatttga ttatataaat
    25801 catatatttg gactattgat aggctttatt ataccttata ttattgctaa actaacaaaa
    25861 ggattaggct atggagatgt aggtctctat agcttatgtt gctttgcatt gggaaataat
    25921 tatgggtttt atgtgatagt tttatcattt attttagcgt ttttgttttt tattatttta
    25981 tacataacta aaatatttaa agatgtagat ataagaaagc aaattccttt tacacctttt
    26041 atttccttgt caacaatttt aataatattt acagagtata atatatttaa tttttattat
    26101 aatttgttat acaaatttat ataacaggag gtaagaaatg tacgtagtag tagggttagg
    26161 taatccagga aagaagtatg agaagactag acataacgtt ggatttgatg ttatagatat
    26221 tcttgctaaa gaatacaata ttagtgttac taaaataaag cataaagctt tgattggtga
    26281 agggagagta ggtactgaaa aagtattatt agttaaacca caaacttata tgaatttaag
    26341 tggagaaaca ttaatagata tatataaata ttataaggtt gatttaagta atatagtagt
    26401 agtatatgat gatatagatt tagaagttgg aaagatacgt ataagaaaaa aaggaagtgg
    26461 aggaactcat aatggcatga aatctataac taagtgccta ggttcaaatg actttccaag
    26521 agtgagagta ggtgtatcta aaccagaagc tggtcaagac ttagcagact ttgtactttc
    26581 tagatttaga aaagaagaat ctgataacat aaatgaagca ttagaaaaag cggcagatgc
    26641 tattgactca ataataagag aaaatataga tatgtctatg aacaaatata atggatagtg
    26701 agagggagat ttaaatgaat gatgtttttt tatatccttt gcaaaattca aaagagtata
    26761 aagatataat aaactgtata aaaaatacaa aaggctcatt attggttaat ggacttttac
    26821 cagtacaaaa acctcatata tcgtattcta tatttaatga tttatcacga caaatgattt
    26881 ttataacaag tagtgattta gaagcaaaga aagtatacga agatttaagt ttttatatgg
    26941 aagataaagt tgaatattta ggttttcaag atatttattt ttatcacttg gatgcaaagg
    27001 acagaaacga agaagcgaag aaattaaaag tattgttaaa actagcaaat aaagaaaaaa
    27061 tcattttagt aacttctatt gaggcagttt taagaaaata cataccaaaa caagttttgc
    27121 tcgatagtgt atctcattat aaggtgggag atagcttaga cttagaaaag ttaactgaga
    27181 aattagtttc attgggatat gaaagagttt caaaaataga ggggtttggt caatttagta
    27241 taagaggtgg aattattgat gtattttcac ttgaatatac aaatccaatt cgtatggaat
    27301 tatttgatga tgagatagat tccatacgaa cttttgacgt atattcacaa aaatcaattg
    27361 ataaattgca acaattctct ataactccat ctagggaatt tatttatccc gaaaaaacta
    27421 cagatgcatt agttaaatta aaaaaagaaa caactaaaaa tactgatgaa ggtacatttc
    27481 aaaatataga ttatatatca agtaagactt attttgaagg tgtagagaac tatatagatt
    27541 atatttatcc agaagaaaac aaaagtatat ttacttattt agcagatgat gcaatagtat
    27601 ttattaatga tataacgaga cttaaagaaa gatgcgaaaa ttatataaat gagtttagag
    27661 aaaattataa attaaatctt gaaagaggtc tggctattaa aaaccaaggt aaattgttat
    27721 atcactatac agatttagag tacttagtaa aagacaagtc tgtggtatta aactcgctat
    27781 tgccaaagtc tataaataac ttttctataa aatctataat aaattttgaa agtagagaag
    27841 ttcctacatt taatggaaag gtagatttgc ttgtagaaga attaaatcgg ctgaaatata
    27901 atggatacaa aataatttta gcaacaaata ccttagaaag agcaaataaa ttaggaaaag
    27961 atttattgga caaaggctta gaaacgacca tttctaaaga tagagatatt gaaattaaat
    28021 cttcacaagt tataattgta cctgcacaca taaacagtgg ttttcagtat aaatctataa
    28081 agtttgttgt tataacagat aacgaaatga taggtgttta taaaagagcg tctaagacta
    28141 gcaataaaaa agttaaaaag ggaaagaaaa tagaatcctt tttagattta agtgttggag
    28201 attatgtagt ccatgaaaat agtggtgtag gtagatacac aggaattgaa caaattacag
    28261 tcaatgctat taaaaaagat tatatgaaaa tagtatatca aggtggagat aatctatatg
    28321 tgccaataga ccagatggac aaagtacaaa aatatattgg tgcagaagta gaaaaagtta
    28381 agttaaataa gcttggaaca aatgagtgga cgaaagcaaa agcaaaagtt aaaaaagaaa
    28441 ttgaagatat gacaaaagac ttgattgagc tttatgcaaa acgtgaaaaa atacaagggt
    28501 ataagttttc aaaagataca ccttggcagg cagagtttga atcgttgttt ccatatcaag
    28561 aaacagaaga ccaattaaag gctatagaag aaactaaaaa agatatggaa tcaagtaagg
    28621 taatggatag gctagtatgt ggagatgttg gttatggaaa aacagaggta gctattagaa
    28681 gtatttttaa agcttgtatg gaccaaaaac aagttgctgt attggttcca acaacaatat
    28741 tggcccaaca acattataat acattcaaag agaggtttga aaattatcct ttgagagtag
    28801 aagttttaag taggtttaaa acaccaaaac aacaaaaaca gattattgaa gatgctaaaa
    28861 aaggattagt agatatttta attggaacac atagaataat atccaaagat ataaatttac
    28921 caaacttagg tcttgtagtc attgatgaag aacaaagatt tggagtaaaa cataaagaag
    28981 ctttaaagaa aattaaatct acagtagatg tacttacact ttcagcaact cctataccaa
    29041 gaacattaca tatgtcttta agtggaataa gagacatgag tgttatagaa gaacctccac
    29101 aagaaagaca tcctgtaata acatatgtta cagagagtaa ggaaagcgta attcaagatg
    29161 agatagagag agaattaagt agaggtggac aggtattttt tgtatacaat agagttgaac
    29221 acattgaaga aatggcaagt atgattcaaa aactcgtacc agatgctaga gtggctgttg
    29281 cacatggaag aatgacttct aaatcattag aaaatataat cctaggattt ttaaataaag
    29341 attatgatgt actagtctgt actacaataa ttgaaactgg tatggacata tcaaatgcaa
    29401 atacaatgat tatatatgat gcagataaaa tgggattggc tcaactttac caattgagag
    29461 gtagggttgg aagaagttca agacaaggat atgcatatct tttgtatgaa aaagataaaa
    29521 ctttaagtga gatagcggag aagagattaa aagctatcag agaatttaca gagtttggtt
    29581 ctggttttaa aatagcaatg agagaccttg aaataagagg agcaggaaat attttaggtt
    29641 ctcaacaaca tggtcatatg gcagttatag gttatgattt gtacgttaaa atgcttaatg
    29701 atgcaattaa aaaagtcaaa ggtgagccta ttgtggagga aattgatgtt gaaatagatt
    29761 taagtgtaaa tgcatacatt ccagataatt atatcaaaga tgagttgatt aaaattgaaa
    29821 tgtataagaa aatagcttct attgaaaaca aagaagacat gttggatata caagaagaac
    29881 ttgaggatag attctctgat atacctaaac cagtccagac acttcttaca atagcttata
    29941 taaaatcgtt atgtaagata ttaaaaatag aaaagataag acaattaaaa gatgaaatat
    30001 tattagttcc aataacaaag tatagaacta aacagaaaat aggttataat atagttacag
    30061 aattagaaga attattagaa aagatgtgca aggtaaaata acttgtaaat ttaagaaggg
    30121 atgttttaaa tttgaaaaaa gtaataacat tggtaatagc tatgattttg gtagtatctg
    30181 tgactgcttg cagttctagt aaaggagaaa ctgtggcaac agttgaaggt acaaagatat
    30241 catcagatga atttaaaaaa actatagctc tttataaaga ttctatggaa caaacttatg
    30301 gaaaagatat atgggataag gaagttgaaa agggtgtaaa atacaaggac aagtttaaag
    30361 atttaattct tgaccaactt ataactacag aagtaatata ttctcaagct aaaaaagata
    30421 acttacttcc taaaaaagag gatgttgaaa aaagttttaa agaattaaaa gacgctatgg
    30481 gtaaagatga aaaatataaa gaacaactta agaaattagg tatagatgat gagtttttaa
    30541 gagaccaaca agagaaagat ttagcaatgc aaaactatca aagtaacttt gctaaaaaga
    30601 ctaaaatatc agatgaagaa atgaaaaaat actatgatac acataaagat gaatttaaaa
    30661 aagatgaggt agaagcttct catattttat tgaaaacagt agatgataat aacaagccac
    30721 tttcagataa ggaaaaagct gaagctaaga aaaaggctga agaggctctt aaagaagtta
    30781 aatcaggtga ggattttgca aaagtagcaa aaaaatattc acaagatact tcagcaagtg
    30841 atggtggtaa attaggattc ttttcaaggg gtcaaatggt tgctgaattt gaagatgctg
    30901 ctttttctat gaaaaagggt gaagtatctg atttagttga aactcaatat ggataccaca
    30961 taattaaagt gacagacaga ataaatgagc aaacatcatt tgaagatgct aaagaaacta
    31021 taaaagacca actgttgaaa aataaatatc aagaacaaat agaaaaatta actaaagaag
    31081 ctaaggtaga aaaagatgaa aaagtaataa ataaaatcac aatctaagac ttaaaaaaag
    31141 agtaatatgc ttaaaaaagc tatatctgga taagatatag ctttttttgt atatttttct
    31201 taacaatggt aaaaataaac ttaaagtaat ttatggaggg attaaaaaat atgaaagcaa
    31261 caggtatagt tagaagaata gatgatcttg gaagggtagt tatcccaaaa gagataagaa
    31321 agacattaag aattagagaa ggagaccctt tagagatatt cacagcaaaa gatggagaag
    31381 tcatacttaa aaaatactct ccaataggtg aattaaatga attttcgcaa gaatatgctg
    31441 aaacattagc tgaagtacta ggatatggag tgttgataac agacttagat tctataatag
    31501 ctgtgtctaa gcttcctaaa aaagattata aagaaaaaag tataagtgat gagttagaag
    31561 caataataag tgaaagaaca gtaaaatatt caaaagataa aaacatttta ccattattca
    31621 aggaagacca aaaagaatat actagtcaag ttatcatgcc tataattagt gcatctggtg
    31681 actgtatagg ttcaattgta gttgtttcaa aggataaaga tacaattgca gaaagtgaag
    31741 aaaaatcttt aaaaattgct gctaactttt taggaaaaca agttcaataa ttttatcata
    31801 aagacctttt acatgaaggt cttttgaagt ttttgtgtaa aatattgaat atagcattaa
    31861 aaatatggta tattaaagtt tgttatataa acagtatgga ggttatgtta tgaacaataa
    31921 caaaaataaa gactcctttc taaaaggagc ccttatactt gggctagcag gtgtaatcgt
    31981 aaaaataatg ggtggatttt ttaggattcc ccttggaaac atgattggtt cagaaggaat
    32041 gggatactat caggctgctt atcctgtgta tactctattt ttaacattag ctactgctgg
    32101 atttccaaca gctgtggcaa aattggtttc ggaaaaagtt gcaattggaa attttaaagg
    32161 tgcaaataag atatttaagg tatcacatac agttttattc attaccggta taatatcatt
    32221 ttgtatatta ttttttggag ccgactacat agtaacaaac gtaatgaaaa atccaggtgc
    32281 gttatactct atgaaagcca ttgctccagc attactattt gttcctgcaa tgtctgcata
    32341 tagaggatat tttcaaggga gacaagatat gactaagatt gctgtgtctc aagttgcaga
    32401 gcaatttttt agagttgtat taggtcttac tttggcttac ttgcttatga agagtctagg
    32461 tcagactttt ggtgcagcag gtgctatatc aggggctaca ataggttcaa tagcatctat
    32521 gctttatttg gtgtttgctt atatgctagg gagaaaagag cgtagagcag agatagatgc
    32581 aagccaaaga tttaaagatg aaagagtgtc ttatattttt aaaaagcttt taactgttgc
    32641 cattcctata acaataggag catcagtaat gccacttgta aatatgatag ataatgttat
    32701 tgtaataaga agacttatgg aagcaggctt tacatacaaa gtggcaaatt ccatgtttgg
    32761 tcaattaaca ggtatggcaa tggccacaat aaatttacca gcagtcataa caactgcaat
    32821 gagtatgagc ttagttccag caatttctaa agcatatgca ttaggaaata agtcaaaagc
    32881 tagaaaagat actaagagtg cagttaaggt aactttactt atagtattgc cttgtgcgtt
    32941 tggtatggct tctttagcaa taccaataat gggtctttta tttccacatg aaccatcttc
    33001 tgtaggaact attttgttta ctcttactcc atgtgtatta tttttaggat taatacagac
    33061 attgactggt ataattcagg gaatgggaaa accaatagta cctgtaattg ctttatgtgt
    33121 tggtatgcta tgtaaaattg taataagtta tactttaaca ggtataccag atattaatgt
    33181 actgggttca gcatttggta cagttacagc atactttgtg gcagccatga ttaacttact
    33241 atatgttaaa aaacacatga atgtaaactt ttctaaaaaa gaatttataa taaagccatt
    33301 tataacagtt atgacaatgt ttataatggt taagttgagt tatggtgctt tagttggatt
    33361 cttaggaaac agcatatcta caataattgc aatatgtgtt ggtggaattg tatatgtagt
    33421 agtaatactt ggaataggtg gaattaaaaa agaagagatt ctaactatgc caaaaggtga
    33481 taaattatat aaattgttaa aaaaagttaa acttataaga taatatagga atatatatgc
    33541 aaataaagga aatactatac aaatagtaaa tctccttatt tgtataataa tataaaaata
    33601 aagtgaaatt tgctaatagg agtgatgtta tgggtaagat aagtattgta ggtcttggac
    33661 caggagacta ttctcttata agccaaggtg tgttagaatc tttaataaat agccctaaag
    33721 ttttttttag aacagagaaa catccaataa ttgataaact taaagaaact atacaataca
    33781 cttctttaga ctacttttat gaaaaagagg aaaattttga taatgtttat ttgaaaatat
    33841 ctgaatttat catagaagaa tcagcaaagg gtgacctagt gtatgctgtt cctggtcatc
    33901 caagagttgc agagaagact gtaagtataa tagagagatt agccaatgaa aagcacatag
    33961 cagtagaaat attgccttct atgagctttg tagacgctat gtttaactat ttggctatag
    34021 acccatctga gggatttaaa ctggtagatg cttttgaaat agaaaattca tatatagact
    34081 tggatacaag tatgataata actcaggtat atgataaatt tatagcatct aatgtaaagt
    34141 taaaacttat ggaacattat gactataatc aagaagtatg tatagtaaat ggagctggtg
    34201 tcaaagattt agaaagtaaa aagtttataa agctttgtga attagacaga aatgaaaact
    34261 tttttgacta tttaactagc ttatatatac ccaaaagttc taaaaagatg tataatacag
    34321 tacatgactt agaaataata gttaatacac ttagaagtcc atctggatgt gaatgggata
    34381 aaaaacaaac acatcaatca ttaaaaaatt ctgttataga ggaagcatat gaactttgta
    34441 atgcaattga taataatgat atagatgaaa tggtagaaga gttaggtgat gttcttttac
    34501 aggttatatt ccattgtcag ataggaaatg aggagggcta ctttgattta aaagaagtag
    34561 taaatggcat atgtaaaaaa ttaattcata gacatcctca tatatttagt ggtgcaaaat
    34621 tagatatgtc taagtttgag aaaacttggg aagaattaaa gaaagaagag aaaggcgaaa
    34681 gtactataac agatggcctt agaaggatac caaaacattt accagctctt atgaaggcta
    34741 gtaaagttca acataaagca gcacttgtcg gctttgattg ggacaatgta gaagatgtat
    34801 ttaaaaaaat tgaagaagaa tatcaggaat tacttgacga acacagggtc gggaatataa
    34861 aatacataaa ggaagagcta ggcgatttat tattttcgat agtaaatcta gctagatttt
    34921 tagacataga ctcaggagaa gccttgaact gtactacaga aaaattcata aatagatttg
    34981 actttataga aaagagtgca atgaacttga ataaaaaatt agaagacatg acacttgaag
    35041 agatggatga gttttggaat caggctaaaa aacaataaaa ttgtggaagg aaatttgtca
    35101 aaaatctaga acttttatca caaagataga agtctatatt ataaacattt ttaggaggta
    35161 aatatcgtga ataaagctga attagtatca aagatggcag aaaaaagtgg attaacaaag
    35221 aaggaagcag aagctgcgtt aaacgcattt atgagttctg ttcaagatgc actagtaaat
    35281 aatgaaaaag ttcaattagt tggatttgga acatttgaga caagagaaag agctgctaga
    35341 caaggaagaa atccaagaga tccagagcaa gttatagata taccagcttc taaagcacca
    35401 gttttcaaag ctggaaaagg attaaaggat ataataaatg gataattaga aatcttgtga
    35461 aaaagtgtgg ataaatttgc cacacttttt ctatagaacc aaggaaggtg ataattatga
    35521 gattagataa atttttaaaa gtatctagga ttataaaaag aagaactgtt gctaaagatg
    35581 catgtgataa agggattgtc actataaatg gaaaagttgc taaatcttct tcagaggtga
    35641 atattggaga tacattagaa atacaatttg gagagaagaa gatgaagttt aagataaatg
    35701 aagtaaaaga gcatgtatta aaaaatgatg caaaagaaat gtacgaaatt ttagaataaa
    35761 attaatagtc ctctagtata ttaatagtag tattattgaa atatttactg gggggatatt
    35821 atggaacaga acataacttt gaaagataga tcaaagctgg ttatttcggg agtcgagcac
    35881 atatactctt ttaatgacaa aagagtagag ctcaaaactt ctgtaggcga gatggtaatt
    35941 gaaggcgaaa acctagatat gagcaagcta agtatagacg aaaatataat tagcatagat
    36001 ggaactataa attctatggt atatgcaaag cctaaaaagc cacaagagag tttcttgaaa
    36061 aaggtattta gatagatgat accttttact caagatgtaa gcatttttta tgctactatt
    36121 tatggtggaa tactcatagg ggtgttgttt gatttttata gagggctaag agggaatttt
    36181 aaattcatca attattttgc tataatattt gatgtattgt tttggtttct agctacggtt
    36241 ataatattcg taacaataaa ccttacagaa ttttttgatt taagatatta tcattttgtg
    36301 gctttgttta ttggttttat tttatactat aacaccataa gtaaaattgt tttatcaatt
    36361 atcaataaaa taattcgttt tgtgagaaat tcttttaaaa aagttacaca ttacatagtc
    36421 agttttttaa ataatttgta ttacgttata atctattcac tacacctact atttgatatt
    36481 atattttata taccaaacat atttatagca acaagaaaaa gtataaaaag aaaatcaaat
    36541 aaaaaattaa agaacaagaa aaaatcaaaa cctaagaaga aaaaaaataa aactaaaaaa
    36601 agggtgtagg aaaaatgaac ttaagaaaaa aattttcagg acagattatt gttatcagtt
    36661 tatttttagg aatatcaatt tttagtatga tgacaggatt tgtatttgag tatacaaaag
    36721 ctaaggaata taaaaaagaa atagcaagtc taaataaaca attaaaaaag actgaaatac
    36781 aaataaacag cttaaagaaa gatgaaaaat catatgaagg agacttagag gatatagcaa
    36841 gaaaaagatt gaatatggta aaaccaaatg aaacagttta tgtagacata aatcgttgat
    36901 taaaacttgc taataagttt acagatgtat tgattttaaa atttaagatt taataaaaaa
    36961 gtcattcagt taaggatggc tttttgtttt tattgaggag ggaatttcat aatgaaagta
    37021 ggagctatag atattgggac aaactcaatg agattattga tagcagatta tagagatggg
    37081 aattttataa acagaaaaaa atttgttaat acaactagaa ttggttatgg tgtggatagt
    37141 aaaggatata taaaagaaga tgctatcaaa agaaatataa aagcattaaa agaattttct
    37201 gataagtgta atgatgaaaa gtgtgaaaaa atttattgta tggggacatc tgctcttaga
    37261 gacagtaaaa atggagatta ctttgttaaa ttagctaaag aagaaactgg aatagatgtt
    37321 gatatagtta cgggaataga agaatcaaat ttgggcttta agggtgtttt agaaggaata
    37381 caaggtgatg atactattat tgttatagat attggaggag gttcaacaga atttattgta
    37441 ggtgattcag aaggaattat atttaataaa agtgagaatg taggtgctct taggatgaca
    37501 gagaggtttt tgaagcacga tattattgaa gatgaagagt ttgaagctat gagttcattt
    37561 atatatggtg agattgataa aacgttaaat catataaaag acaaaggatt aaaaactctt
    37621 ataggtatag gaggtacgat tacatcatta tcagcaatga atcaagaatt agagatttac
    37681 tctatggaaa aaatacataa tagtaaaata cacaaaaaag aaatagaaga aattctacaa
    37741 aaattaataa agatgacatt aagtgataaa aagaacttaa aagggctaca agaaaaacgt
    37801 gcggatatta taactgctgg tgtaaaaata ttgaatataa taatggaaaa attagaaata
    37861 gaagaaataa ccgtaagtga atacgataat ttggaaggct taatatgtca aaagtcaaaa
    37921 aaaatgtatt aatatttttt gatttttaaa accgattatg acaaaaaaaa ttactcctct
    37981 ttgttacaat tcttaatata aacaaaagag gaggtttttt tatgcaaaga agtgtagcag
    38041 ttgtgaagaa taagactgta aaaccaaatg tcataaaatt aataagcgga tatattgatt
    38101 ttactacggc ggcattcgct gtgatgggat ttttacttag taggtctatt atagtagact
    38161 ctgtagctcc tttaggaatt gcctttttta tatgtgcatc aaagattgat aagtacaaga
    38221 tacctgtatt catatcaaca ttattaggaa tattgttatc atctaatgat tttggaaatg
    38281 tagcaaaata tgctgtgtgc cttacaatat ttatggctat gaataaaaaa ttaaaattat
    38341 cagattcaat tgctaaggtt gcatttatag gtgcaataat actacttcca atctccatgg
    38401 gacaagcttt cttttcaaat aggtatgtat atggtcttct tatagcagga gtagaagcaa
    38461 taataatgtt tatatctata tatgtgtttt cttatgggat aggtttaatg gccaatgtca
    38521 acaataggat gtctgtacgg acagaagaag ccatatcaat aagtttactg ctaaccttta
    38581 gcataatggg aataggagat atatctctgt ttggaatatc aataaggacc attttatcga
    38641 ccgtattgat attgctgacc tcaatagtag gtggagctac tatgggagca tctagtggtg
    38701 taattattgg tgtagcatcc attttaaata atatgacatc agctgtttat atggggatat
    38761 attctttttc aggattaata agtggagcat ttaataaaat aaataaatat ttctgtatac
    38821 taggatatat tctaagttgg acaataatat acctatatac ttctggtatt acttctaata
    38881 tgatgcaatt aagagatata ctattaggtt gtttgatagt actagtattg ccagagcgat
    38941 tatttaataa gattgaaaaa ttaataaaaa gtaatgtggc ttcaaatgaa atcgtatacg
    39001 attatattat gagaagcaaa aacctaacta atagcagatt gaacagtatt tataaaactt
    39061 atgatgacct tgcagataca tttgataaga taagagaaaa agacaaagtg ctagaccaaa
    39121 gagacatagc taatgtaata gatatgattc ataatgatga atgtaaaagt tgtagtatga
    39181 gaagaatgtg ctgggagtca agatttaatc atacatacac tatgatatat aacattcttg
    39241 aaaaaattga ggagaaaggg gagttaagtc taaacgatat acctaaaaat tttagaaagg
    39301 aatgtatgaa accagagtca atagtgaaaa tatcaaatca ctattacaaa atgtttgtat
    39361 tagattatga ttggagtgtg aagttttcag aaagtagaaa gttaatagca aatcagataa
    39421 gaagtatttc aaaatccatt aaatccttat ctcaagattt agaaggcgac ataatgctag
    39481 atatagaaaa ggaaaaaaat atatatgaac agttagaaag atatgatata acagttgata
    39541 aagtaagtta cttaacaaaa agtaacagtg agtttgaaat atcaatagaa aagaaaactt
    39601 gccatgatgg atgtatgtgt gaagataaaa ttgtaaatat aatttcagac ctagtagggg
    39661 aaaatatgtc tgttagaaaa ataggatgtc actgtttagg aggtaaatgc aaggcaacat
    39721 tcgttaaatc tcaaaaatat aaggctgtta cagaagtttc agcaatgtca agggatgggc
    39781 atatcctttg tggagacaat tacacataca tggagataaa tgatggtaaa tacatgatgg
    39841 ctataagtga tggtatggga aaaggtaaaa aagcatatga agaatcttct gccactattg
    39901 atatactgga aaaaatgata gatgcaaaaa ttaaagatga gatagtcatt gatactataa
    39961 ataatatgtt gttgttaaag tcttcagaag agatgttttc aactctggat ttgggaattt
    40021 tagatttaaa acgaggttgt ttagaaacta taaagatggg agcgtgttct acttatataa
    40081 aaagagagga tggagaagtt gacttaatat cgtcatcatc attacctgtg ggtatattat
    40141 cagatgtaaa aattgataga aaaaatgtaa aagttaagga aggagactat gttataatgg
    40201 tttctgatgg aattgtagat gcaggaagaa ataacaattt aggagacaat tggttaatat
    40261 acttcttaaa gaatatagag actacaaatc caaaggaaat ttcaaattta atattggata
    40321 gagcattaga gttacaagcg ttacaaattg aagatgacat gactgtttta gttacgaaaa
    40381 tatgtacaaa ataaggttta caagattatg tgtataagat gtggataact tgtgtataat
    40441 atgttaatag acttttgaaa aaagtatagt tattaacaaa aataacatat aaatcaacaa
    40501 aatttgttga taagtatggc agaaatgtta ataaaatgta aaaaaagaaa aaacaaaagc
    40561 tattatcaaa agagattcat gttgaaataa ctaaatttct aagtaaagaa aacctgtgaa
    40621 tatgttgatt attatgtgga taactattaa ttcgatattt atttatatag tatgaataat
    40681 tgaataatat atctaaaaaa agccatccta ttattaagta aacttattga aaggatggct
    40741 ttttatgaat agaaaattgt gcaaagcaat aataccttta tttatttcta ttttttgcat
    40801 gttaataata agtataaaag ctgaccaagg atatcaaaag aataatgata gagcaattac
    40861 tgtcatgaat aataatgata ctgaagatga tgctgaaaaa aaacaagaaa tagactatga
    40921 aaaaacatgt tggaatttgc aatctttgtt taaaagtgat gaccaatgga aaaaagaact
    40981 taagagtttt gataaagata ctaaagagtt gaaaaattac ataggtaaag taacaaaatc
    41041 gccaacacat ttgtcttttg ccttaaacat taaagaaaaa cttgatataa gactaaataa
    41101 actttctgcc tatgtaaaat taaaacaaga tactaataaa aattcgtata agtacttaga
    41161 tatgaatgat agtatgagta aatcctatgg gaattatatg gggatttgtt cagatttaga
    41221 gttagaaata ctaaaattat caaacaaaga ttacaagaaa attatttcaa ataaaaatat
    41281 aaataggaaa tatggtgcat atttaagaga tataagaagg aataaagtac attatttgga
    41341 tgataaatca gaagatattc taagcaaagt atcttcaata agtagtcttc caagccaagt
    41401 atatgaatta tttagaaata tggatagaaa aactaatttg acaccagctc aatatgcgag
    41461 tgaattagag tcatcagata gagaaaatag aaaaaaagct tatcaagatg aacttataac
    41521 ttacaatgat aatataaata caattgcagg tttaattact ggtcaagtta aaaagaatat
    41581 tttttattct caggaaagag gttatgagtc ttctttagaa atgtacctgg aatctgataa
    41641 tgtagatgaa aaagtataca ataatttgat aaggactgta aatagtaata tggacagtct
    41701 acacaaatat atagatttaa gaaaaaaagt attaaaatta gataaggttc attcatatga
    41761 tatgtttgtg cctatggtta aggctgttga taataatatt aattatgaaa aggcacaaag
    41821 tatagtatat tcagcgttgt cacctttagg aaaagaatac aatgatgtag tatataaagc
    41881 tttcaatgaa aaatggatag atgtttattc acatgaaaat aaagtaagtg gtggatactg
    41941 cttatctgtt tatgaaaatc atccatatat acttttaaat tataataatt cattaggttc
    42001 agtttcgact ttatcacatg agcttggaca tgctgtatat gaatatttaa gttctaagaa
    42061 tcagaattat tttaattcaa atccgtctat atttactcac gaagttgcat ctacaacgaa
    42121 tgaagcatta ctttacgaga tgcttataaa agaagctaaa ggcaatgatg aaaaagctta
    42181 ttatataaca cagtatttag acttgataaa agatactctt tatacacaaa ctatgtatgc
    42241 tgaatttgaa aaaactatac acgagttagt agaaaaagga aaaagtgtaa acgcattagt
    42301 attaaatgat gtttggggac aacttcttaa aaaatattat ggacaaagct atgaattaga
    42361 ccaattatct aaggtcggat gggctagaat cccacatttt tataatagtt tctatgtcta
    42421 taaatatgct acaggttgta gtgcaggagt aagttttgcc caagacatcc taaagaatgg
    42481 ttcagataac tatatgagct ttcttaaaaa gggaagttca gattatccaa taaacttgtt
    42541 aaaatcaagt ggcataaatt taactaatac aaaacccata gaaaatacaa tcaaaaaatt
    42601 tgatagttta gtagcagaac ttgaaaagct attataaaca ttattgtaat tcacatggta
    42661 aatatatcga attaatgata aaatatacta aaagtttaaa gtcctatcaa gataggactt
    42721 tttatttatt aattagtggg agatgattct atgcaagtta aagttaaaaa ggctgtaata
    42781 ccagcagcag gtttaggaac tagatttttg ccagctacaa aggcacaacc aaaagagatg
    42841 ttaccaatag ttgataagcc aactctacaa tacataatag aagaagctgt ggcctcagga
    42901 atagaggaaa tactaataat aacaggtaga aataaaaaat ctattgaaga ccactttgat
    42961 aaatctgtag aattggaact tgatttagag aaaaaaggta agaaagaatt gttggaggta
    43021 gtacaaaaca tatctaacat gattaacata cattatataa gacaaaaaga gccaaaaggg
    43081 ttgggagatg caatttattg tgcgaggcat tttataggtg atgagccgtt tgcagtaatg
    43141 ttaggggatg atattgtaga taatgatgta ccttgtctaa aacaactaac agatgcatat
    43201 gaggaatata gaactacaat attgggtgtt caaaaggtaa atcaagaaga tactaataaa
    43261 tatgggataa tagaagcaaa aaatatagaa ggtagagttt acaaggtaaa agacatggta
    43321 gaaaagccag agtcaggaaa agctccttca aatattgcta ttttaggtag atatataata
    43381 actcctgaaa tctttgatat tcttaaggat ttaccaccag gtaaaggtgg agaggtacaa
    43441 cttacagatg ctttaaaaat attatctaag aaagaagcta tgtatgcata caattttgaa
    43501 ggcaagagat atgatgttgg ggacaagcta ggatttttag aagctactgt tgactttgct
    43561 ctaaagaaag aagaccttaa ggaagatttt ataaaatatt tgaaacatgt atgtagtgaa
    43621 tttgataaaa ataacaatgt gttatacaat aatacagatg aaaaaataga tttaattgaa
    43681 gtcaatgaag ctagagaact tgaaattcaa aaataattaa tgaaaggtga tgtatggtgg
    43741 caaaatcaag tcagaaaaga attaatagaa taatagctgt tgggattgtg ggaatcctcg
    43801 taataacgag tataacagct gttttgagta tgattgcaac tatgtaataa gataaatgac
    43861 agcagttgat atacataaat ataaaaacca tatataactt gatgtagtca aaaacttaca
    43921 atattttagt tatatatggt ttttagaatt tataaatgta aaaaaaaatt tttataatag
    43981 ttgcatattt taaaggaaaa tattattata agatataaat atagtgataa atttataaaa
    44041 acgtgctaag attggacttg aaatacagta atatagtagg taataatgtt ttaaatttta
    44101 tttattgacc ataatatata aataatgata ttattagact taactgttta aataaaactt
    44161 ttctttttca tgccttcaat ttccaaaata agtatgtata taaatgaata tatagatgag
    44221 gaggattttt ttgattttag atgataaagt attagaagga ttaggtagta agaccttagt
    44281 tgagctacga gagatagcta aagaattaaa aataaaatca attactacat ataagaaaaa
    44341 tgagttaatt gagattataa attccaaaag taaaaatgag gaaaaagtaa acgaagagac
    44401 taaagaaaaa aatgaagata ttaaagaaga cataaagaat agaaaagaaa atatagagcg
    44461 tgaaagtata gaaaaagaag ttgaatataa gagccctacc aaatcataca acaagaaaga
    44521 aatagatacc caaaatattt cccaaaacca agaacataga aatcaaagaa atgactataa
    44581 taagacaacg agtgtaaatg atagtaataa gtcatcaaat atatctaata gaatggtcag
    44641 aaataataat aaaaactatt atatgcctaa acaagttgat gaatctaaga tagtagatga
    44701 atttaacaca tcaaaagagg atgaagtagt aggtgtactt gaaattctgc cagatggatt
    44761 tggtttttta agaggttcaa attatttgtc tactgaagga gatgtttacg tttcaccatc
    44821 tcaaataaga agatttaata tgaaaacagg agacaagatt aagggaataa ctagacatcc
    44881 aaaaagtgga gagaaattta gagcactttt atatgttcaa aaaataaatg atgaaaaccc
    44941 tgacacagct atacaaagaa atgcgtttga gacattaaca ccaatatttc cagaagaacg
    45001 acttacactg gaaactaata gaaatgaaat agctacaaga attatagatt taatttcacc
    45061 tataggaaaa ggacaaagag gattgatagt agcacctcca aaagctggga aaacagttct
    45121 tttaaaaagc gttgcaaata gcatagctaa aaatcatcca aatgttgaac ttatagtact
    45181 ccttatagat gaaagaccag aggaagttac tgatatgaaa gaatctattg aaggagacgt
    45241 tatatattcc acttttgacc aagtatcaag tcatcatgtc aaggttgcag agatggtgtt
    45301 aaatagagct caaagattag ttgaacatgg taaagatgta gtaattttac tagatagtat
    45361 aaccagattg gcaagggcat ataaccttac aatatctcct acaggtagaa ctttatctgg
    45421 aggtattgac cctggtgcac ttcatggacc taaaaagttc tttggtgcag caaggaatat
    45481 tagacagggt ggttctttga caatattagg aacagcattg gttgaaactg gttctaggat
    45541 ggatgatgta atatttgagg aatttaaagg tacaggaaat atggagctac atttagatag
    45601 aaaattagca gaaaaaagaa tattccctgc aatagatatt tacaagtctg gtacaagaag
    45661 agatgattta ttgcttgatg atgaagaaaa gactgctctt tggagattaa gaagagaaat
    45721 gagtaataat tcagtaatgg aaattacaga taaagtcatt gaacttataa agagaactaa
    45781 ggacaataaa gagtttgtaa aatcaataaa gaatttgtaa aatcaataat acaaatgcaa
    45841 atatggatta tataaactaa tagaaaaatc acttgaatgg cataataagt tgtgctataa
    45901 taatgtagtt gataatgtaa aaagaaagtt aatataatta atttttttaa ataaagagaa
    45961 gaggtgacta taatgcaaaa ggaaatacaa ccaaaataca atccagttga agtgcgttgt
    46021 gcttgtggga acacatttgt tgctggttca actaaggacg aaataaaagt tgaaatatgt
    46081 tcagagtgcc atccattcta tacaggaaaa caaaagaaca tagaaaaagg tggaagaatc
    46141 gacaaattca agaaaagatt caaaatggac taatttttat aaaagtggag ttggaggaag
    46201 ccaactccta ttttattaca aaaaaacatt catattctac tttaaattgt ctttttgtat
    46261 tataataata aatatgtaaa attgagtatt ctaaatacaa taaaatgagg tgagtggatg
    46321 gcaaaacaag ctgtaggtgg gcaagctgtt attgaaggtg taatgatgca gtcaaaagac
    46381 aaaagagcgg tagctgttag aaaaagtgac ggagaaatag cactaaaaga agatagaata
    46441 aaaagttggg taagagataa gaatatagat aagatacctt ttgttagagg ttcttttgtt
    46501 atgatagata caatgattca aggcataaaa agtttaaact tttcttcaga gttttttatg
    46561 gaagaagctg aagaggataa atttgattta tttataaaga aaatttttaa agataaggca
    46621 aatgatataa ttataatatt ttcattggtc atagcaatgt tactttctgc tggattattc
    46681 atttttatac ctacattggt aggaggagct ttttctaaag taatgcctaa tgattttatg
    46741 cttaatttaa tagaaggaat cataaggata gctatattat ttgcatatat agtattgatt
    46801 tcacgaagta aggatataga aagagtcttt caatatcatg gagcagaaca taaatctata
    46861 tattgctatg aaaatgattt agaacttaca gtagagaatg ctagaaaatt taaaagatta
    46921 catcctagat gtggtacaaa tttcctattt atagttatgg ctgtatcaat aatattgttt
    46981 gcattttttg gttggccaaa tccaattctt agaatattta tgagaattat atgtgtgcct
    47041 atagtagcag gtttatctta tgaggtaatt agagttcttg ggaaatatga taatggattt
    47101 actaaaatta ttgcatatcc aggaatgatg ttgcaatatt ttacaacaaa agagcctgat
    47161 gatgagcaat tagaggttgc tttggaagca ttgaaagcag tagtagatta gagaaaagga
    47221 tatttgttat gacgataaaa gatataatta ttaaatattc agataaacta aaagatataa
    47281 gtgatactcc aagattagat acagagttat tgttacaaaa aacattgggt gttgatagat
    47341 tatatattca cttaaatctg aataaagagc taactgaaga acaaaaaaca aaatttatgg
    47401 gttttgcaga agaaagatta aatggaagac caatagcata tatagttgaa aatagggagt
    47461 ttatgggatt agattttttt gttaaggaag gcgtattgat tccaagacca gatacagaaa
    47521 ctttagtaga agaaataatt gaaatatgta gagaaaaaaa agatgtaagt atattagata
    47581 taggaactgg ttctggagct attacaataa gtttagcaaa gtacattgaa aattctaaaa
    47641 tcatgtcttt tgatatatca gagacagcat tagaaatagc taaaaaaaat gctattataa
    47701 atgaagttgg tgaaaaaata aagtatatta attctgattt atttacagca ataagtgata
    47761 gtaacataaa attcgatatc atagtttcaa atccaccata tattaaaaaa caagatatag
    47821 aaactctgca caaacaagtt aaagattatg aaccatataa tgctcttgaa ggtggagaag
    47881 atggattaga cttttataga agaataacag aacaaggtaa gaaatattta aataagtgtg
    47941 gaatattagc atatgaagtt ggtcataatc aagctgaaga tgtaataaat attatgaaaa
    48001 gtaatggata taaaaaaata tacacaaaga aggatattca aggcattgat agagttgtta
    48061 taggttacaa tatatgatat aatcaacaat tgatatgtta catttaatcg aggtgaaagt
    48121 atgttaaaaa aattagaggt attggaagat acatataaag acttaagtga aaaaataggt
    48181 gatccggatg taataaatga tcaaaaagtt tggcagaaat atataaaaga acatgctgac
    48241 ttggaaccta ttgttatgaa atacagagag tataaaagcg ttttagatag tataaaagaa
    48301 tcaaaagaaa ttttacaaga agagtcagat gaagaattaa gagaattagc taaaatggag
    48361 ttagctgaga tggaagaaaa agtagcacct ctggaggaag aaataaaaat actattattg
    48421 cctaaagacc ctaatgatga taagaacgtt atagttgaaa ttagaggtgg agctggagga
    48481 gatgaagcag ctctatttgc tggtgattta tttagaatgt actcaaggta tgctgaaaga
    48541 agaagatgga aaatagaatt attgagtgca agtgatactg gagttggtgg atataaagaa
    48601 gtatctttta tgataaaagg taaaggtgct tattcaagat taaagtatga atctggagtt
    48661 catagagttc aaagaatacc atcaactgaa tctggtggaa gaatacacac atcaacttct
    48721 actgttgcag tattaccaga agttgaagat gtagaggttg aaataaatcc aaatgattta
    48781 agaatagatg ttttccgttc ttcaggtaat ggaggacaaa gtgtcaatac tactgactct
    48841 gctgttaggg taacacatat acctacaggt gaagtagtat cttgtcaaga tggaaaatca
    48901 caattaaaaa ataaagagca agctttaaaa atattaaaag ctagacttta cgataaagca
    48961 ttggcagaac aacacaaaga tatagcagca gaaagaaaaa gccaagtcgg aacaggagac
    49021 aggtcagaaa gaataagaac atataatttc cctcaaggta gaataagtga ccatagaata
    49081 aatttaactt tatataagtt agatgcattc ttagatggag atatagatga aatgatagat
    49141 gctttaatta ctgttgacca aacagaaaaa atgactgcaa tataagtaat gttttaaaga
    49201 agctgtttct tcctagaaat tattttctat tttgaaacag ctattttgca ttttaggtca
    49261 tgttatcata ttctattgta tataattgtt atatacaagt ataggagggt tatatgatac
    49321 taaaagtaac aataattggg cttttggcag gtgttatagg gacaggatta ggaggagtaa
    49381 tatcagccat ttttaaaaga gaggtcgata aatatctaag tttttttatg ggattatctg
    49441 gtggaataat gttggctgta gtggtgtttg atttaatgaa agaatccatg gacaaaatgg
    49501 ggataatcaa tacagttata tttacgtttg ttggagctct cataactatg tacataaaaa
    49561 caaaattaga tgtgtctgga aatatggcat ctggatatct tatattcata agtatattac
    49621 tacataattt accagaagga ctagccattg gttcttcttt tatgtcaact gaaagtttag
    49681 gtattacact tgctatagtt ataggtctac ataatatacc agaagggtta gctatggcat
    49741 taggcttagt ttgcaataaa atgaaactaa gtaaagttat tttgtttact gtaatagctg
    49801 gattacctat gggtctagga agttttttag gtgtttattt tggaggagta tttacttctc
    49861 ttataggagt atttcttgct acagcaggag gtactatgat gtatgttgta ttggaagaaa
    49921 tttttccaca ttcaaaaagt gtgtattgta taattggttt cttgttaggt acaatgattg
    49981 taaattatat ataaaattaa aatgaaagca ggcatacaaa agatgaaaac tattataagt
    50041 aatattgata taaataatat tgattatgag gaaataaaaa tacaagcaaa acttcttaga
    50101 gaaggtaaaa cggttatttt tccaactgag acagtatatg ggttgggtgc aaatgcatta
    50161 gatgaaaatg cagtaaagaa gatttatgaa gctaaaggaa gacctagtga taatccattg
    50221 atagtccata tatatgaaaa agaagaagta tatgacttag ccaaagatat aagtgataaa
    50281 gctaaacttg ttatagaaaa gctttggcca ggacctataa caattatatt aaataaaaaa
    50341 gatataattc catacaaaac tagtggaggg cttgatacag ttgcaataag gatgccttct
    50401 aatgttattg ccagggcaat aataaaagaa gctggtatac ctattgcagc tccttctgca
    50461 aatatctcag gtcgcccatc tccaacaaaa gcaaaacatg tatatgaaga gatgaatgga
    50521 agagtggatg gaatagtttt aggaggagac agtaattttg gattggagtc aactgtattg
    50581 gatttaacag aagagactcc tatgatactg agaccaggaa gtataactaa agaagtttta
    50641 gaggaacttc ttggagaagt aaagcttgac ccatcattaa gtaaaaaaga agataatcaa
    50701 aaagctaaag ctcctggaat gaaatataaa cattattctc caaatgcaga tgtatatata
    50761 atatctggaa aaagagaaaa tgtagcaaca aagattaatg atatgataaa atctaataga
    50821 gacaaaggtc taaagacagg tgtaatgtgt attagtagaa accgagagtt ttatgatgga
    50881 gaagtaatcg atttaggaaa ctctcttgaa gaagttgcaa gtaatctgtt tgatgctctt
    50941 atagaaatgg acaaaaaggg tgttgatgtc atatattcag aagagttccc caagactgga
    51001 gttggacaag caattatgaa tagactactg aagtcagcag gatacaaagt gataaaggct
    51061 taagagggag ttgtaaaata tgaatatact tattgtgtgt acaggtaata cttgtagaag
    51121 ccctatggct gaggctatac taaggaaagc aattaaagaa tctggaagaa gtattgaaga
    51181 atattctata tcatcagcag gtatatctac agcaaatgga atgggtgctt ctgaaaattc
    51241 tatagaagta ctaaaagaaa tcggtataga cttatcaaat catagaagta aagtaattac
    51301 taaaaaatta attgatgaat cagatataat actaacaatg actaaatctc ataaagaaat
    51361 tttagtacaa gcagttccaa aatgcaaaga aaaagtgtat acttttaaag ggtttgcaaa
    51421 taaaaatgag gaagatatat ctgacccatt tggtggaaat ttggatattt atagaagcac
    51481 tatgagagaa ataatgtatt ctgtcaacga aatagtaaaa aaaatatgaa acggaggata
    51541 aacaaatgaa gataggatta ggctgtgacc atggaggata taatttaaaa aaagaaataa
    51601 taagctattt agaaagtaaa ggtatagagt gtgtagatta tggaactaat aatgctacag
    51661 attctgttga ttatcctgtt tatggagaaa tagttgcaaa ttcagttata aataaagaag
    51721 tagattatgg aatattatgt tgtggtacag ggataggaat atctttagct gctaataagg
    51781 ttcctgggat aagatgtgca gttgtatcag atgtattttc tgcaaaaatg tcaaaagcac
    51841 ataatgatgc aaatatgtta tcattaggcg aaagagtttt aggaaaaggt ctagcacttg
    51901 agatagttga agcatggatt aatacggatt ttgaaggtga tagacatgct agaagagtaa
    51961 acatgattaa atcaatagaa gaaaaacata ataaataata aaaattacag ttttatcagg
    52021 aggaattatc aaaatgagca aagtggtaga gacaaaccat ccattaatac aacataaatt
    52081 aactttaatg agagataaaa atactggttc taaagacttt agagagcttt taactgaaat
    52141 tgcaatgtta atggggtatg aaataacaaa agatatacca ttaaaagatg tagaaataga
    52201 aactcctatt caaaaaacat catctaaagt agttgcaggt aaaaaattag caataattcc
    52261 aattttaaga gcaggtcttg gaatggtaga tggattagtg agcttaatgc cagcagcaaa
    52321 agttggacat gtaggactat atagagaccc agaaacatta aaaccagttg aatattattg
    52381 taagcttcct caagacatag gagaaagaga tataatagta gttgacccta tgcttgcaac
    52441 agggggttct gctgtagcag ctatagattt acttaagtct aaaggagcta aaagtataaa
    52501 attagctaat ttagtagctg caccagaagg tatagcagaa gtgcaaaaat atcatgatga
    52561 tgttgatata tatgttgcat cagttgacga aagattaaat gaacatggat atataattcc
    52621 tggtcttggt gatgctggag atagattgtt tggaactaaa taaaaataaa taactataaa
    52681 tatttattag ggactttctt atatagtgta tataatttta tgtaagaagg ttctttttta
    52741 tatatttttt ctcaaaatag gaattattga attgataaat ttctcgaatt gagaataaaa
    52801 agtttttacc aattaaaaaa gattgcttat tttacaaggt tttatagaat agtagtctat
    52861 tttaatgtgg catgttagtt gcttacgatt ataggtatta agtgtattag ttaaattgag
    52921 aattgaatat taataatatt attgggagtg gtaatacatg aagaattgta tagtagtaag
    52981 aggggctgga gatttagcaa cagcagttat tcataaatta cacaacagtg gttttaaagt
    53041 agttgcgtta gaaatagaag agccattagc tataagaagg caaatttctt tttgtgaggc
    53101 tgtttatgaa aaaaaagtaa ctgttgaagg tgtagaatgt atattttgca atactgaaaa
    53161 agaaatagag gaagttttat ctcaacataa agtagccttg attatagacc caaaaggaga
    53221 aaaattatct aaattaaatc caatcgtttt ggttgatgga atactcgcta agaaaaactt
    53281 aggtacaact aaagatatgg caccacttac aatagcttta ggtcctggat tttgtgcagg
    53341 agaagatgta gatgttgtta tagagacaat gagaggtcat aatctaggaa gaataataac
    53401 taatggtaga gcagaaaaaa atacaggagt accaggagca ataaaaggtt tttctaaaga
    53461 gagagttatg cattcacagt atgatggcat aatggaaaat gtatgtaaga taggtgatat
    53521 agttgaaaag ggagacctac tttgctatat taataattat gaaaaaaaac atgaagttag
    53581 agcaacaata tctggagtcc ttagaggttt attaaaggat ggagcaaagg taaacaaaaa
    53641 tttaaaaata ctagacatag accctagaaa agaagaagtt aagaatgctt ttacaatatc
    53701 agataaagct agatgtatag ctggaggggt tttagaagcc atactaaaca atgggattta
    53761 tccccaaaat taatttatat tagataaagc tattaatatt ttattaagat gatataataa
    53821 atttaataga ttaaagagag catatgacgg gtatttaaaa tttaaatggt aaaaatgctc
    53881 tttttttatt ggacattcaa ttaacatgtg tatataatat aaaaataagt atttatttag
    53941 gttgaaatct aataaatata taataccagt acataagcaa agaggagaaa agtaaattat
    54001 gagaccatca tgggatgaat acttcatgga aattgcagaa gtagtgaaaa agcgttcaac
    54061 ttgtattaga agacaagtag gagctgtaat tgtaagagac aaacaaatat taacaactgg
    54121 atataatggt tctccgagaa atcttgaaca ctgtgaaaat attggatgta agaggcagga
    54181 attaaatatt ccctcaggag aaaggcatga attatgtaga gcattacatg ctgaacaaaa
    54241 tgcgataata caagctgctc ataatggtat tagtgtagat ggggcaactt tgtatgttac
    54301 tacaagacct tgtgttttgt gtgcaaaaat gtgcataaat gcaggtatat tgaaaattgt
    54361 ttatgaaggt gattatccag atgatatgtc tacagaatta ttaaaagaag caggaataga
    54421 actcataaaa ttttagtgga taaaatttat atgacaataa atgtcaaatt atgacactga
    54481 aatacaatgg tatcaaatga ttaaaagaaa gtatttgaaa aatcatcaga ttagtagtaa
    54541 gatatatttt ataattaaat aaatttatga gatagattaa ttacatgtta tttattttat
    54601 aataatgagg gatactattt atgagtaaaa gaaatacaca tacagaaatt gcaaagttgt
    54661 ttagtttaat aagtcaaata ggattgatga ttgtaatatc aatattagga tgtactttct
    54721 taggaaaatt tttagatagt aaattgaata ctactccagt tctgacaata atatttttat
    54781 tgttgggtgt tggaggtgct tttagtggtg tttataaaac tctaatagta tatacacgaa
    54841 ggaagtgata tattggatat aaaattactt aaccaggtaa ggtcagtaac aaaaggtata
    54901 gtaatatttg atgtagtttt aattgtgcta atgttgataa catcaacatt aagtaaacca
    54961 gtattattag gacttatatt tggctctata atagctatgt taaattttag attattggcg
    55021 atatcactgg aaaaatcagt gacatttcct gctgggaagg cacaagctta tgcatcagca
    55081 caatatgctg ttagattatt tataatggca gttgttctaa ttgcatcagc tacagtacca
    55141 catttaaata taatcggaac agcattggga ttattgagca caaagtttgt catattatca
    55201 aaaaacttta taaataaatt aaagaggaag gaggcataag tatgaatcaa gcgcattatt
    55261 atctcatagg aaactttaag attagtgaaa caatactagt aagttgggga ataatggcct
    55321 ttttagcgat agcatcttat tttttgacta gaaacttaaa aaaagttcca actagtaaag
    55381 ttcaaatatt cttagaattt gcagtaggtg gtcttgctaa aatggttaca gatgttatgg
    55441 gtaaaaatac agtaaaaaga atgccatata tgataccata cataggaagc ttgtttttat
    55501 ttttcgcatg ttcaaattta agcccattac ttggattaag gtcaccaaca accgacttag
    55561 acacaactgc tgcatgggca atgattacat tttttatgat ttattttgca ggagttaaat
    55621 ttaaggggtt atcatacttt aaagaattgg ctcaaccact tgccataatg ttaccaatca
    55681 atattatagg tgagttagct agaccaatat cattaagttt ccgtccattt gggaatattt
    55741 taggtggaac aataataatg ggtctgtttt atcaactttt aggttttata tctagtttaa
    55801 taccaggatt atcaatacca attggagaaa tattaatacc agtcccatta cacttgtact
    55861 ttgacttatt tgcaggattg ttacaagcat atatatttat aatgttaaca atggtattta
    55921 tatcaagtgc aggagagtta gattaagaaa tcaacttata ttaagataaa aataaaataa
    55981 tttaaaaaat taaagtttta aggaggaaat aattatggaa acagcaatag tagcggcagc
    56041 atcagcaata ggagcaggga tagcagttgc aacaggtata ggtgcaggta taggtcaagg
    56101 tatagcagca gctaaagctg cagaagcagt aggaaaccaa ccagaagcta aaggtgatat
    56161 aacatcaact ttattactag gagttgctat agcagagtct tcagcaatat atggtttggt
    56221 tatatcaata atacttctat tcgtaaatcc attctttaaa tacttaggaa tgtagattta
    56281 gtccttaaat attttgagat aggtttatag gtaaatcatc tcaaacttat aatcatgaga
    56341 tgaactttat catctcgtga ttataagtag ttatgattta tggaaaggag gataattatg
    56401 gaaaaagcac tagtaggtat aacgtgggaa tttgtgttcc aaattgttaa tacttttata
    56461 atatttttac ttctgagaaa gcttttattc aagccagtat taaatataat tgaatcaaga
    56521 gaaaatgata ttaaaagtga tttggcagaa ggcgaaaaag caaaaaatga aggtttagct
    56581 ctgaaaaaag aatatgagtc aaaaatcaat tttgccaagg atgaaggtca agaaatcata
    56641 aaacaagcaa ctataagagc agagcagaaa tcagatgata tagtaaatac tgcaaagaaa
    56701 gatgctcttg atataaaaga aaaagcaaac aaagatatag aacaagaaag acaaaaggtt
    56761 ataaatgaaa tcaaaaatga tatatctaac atagcactac ttgcagcatc taaagtcatt
    56821 gaaaaagatt tagataaatc taaacatgaa gaattgatag aaaactttat aaaagaggta
    56881 ggggaagcta aatgataaat gtaatagcaa atagatatgc agaagcccta tttcaattag
    56941 gagaagaaga aaattcaact gatgtcttat tcaaagaact agaaaaagta gtagatatga
    57001 tgactaaagt tagtaaagat ttctacaaag ttttaaaatc accattagtt tcaaaatcag
    57061 aaaagaaaaa cttggtagaa attattttta gtaaagaagt aagttctaac ataaaaaact
    57121 ttttaaaagt tttagtagat aaagatagaa tatcatattt agaagatatc gaattagctt
    57181 ataaagaatt attaaataag aaaaacaatg taattgatgg agtagcaata agtgctattc
    57241 caatgagtga aacagatatt aaagaacttg aagtcaaact ttcaaataaa tacaacaaaa
    57301 atgttactat agaaaatgtt gttgacaaga ctatactagg gggagttcta gttagaattg
    57361 gaaatgaaca aatagatggc actgtgaaaa ctcgtcttga taagatgaaa gaaaagctat
    57421 ctgaagtaat atcttaagaa tggcggtgaa cccatgaact taaaacctga agaaataagt
    57481 tctataatta aacagcaaat aaaaaattat gagaataaag ttgagttgac agatacaggt
    57541 agtgttttaa cagttgggga tggtatagcg agtgtatatg gattagaaaa agctatgtct
    57601 ggtgagttgc tagagttccc aggtgaaata tatggtatgg cacttaactt ggaagaagaa
    57661 gtagttggag ctgttatcct tggagatgac agtgaaataa aagaaggcga tatagttaag
    57721 agaactggaa gaatagttga agttccagtt ggagaagctt taataggtag agttgtaaac
    57781 tcactaggtc agccaataga tggaaaagga cctatagcgt acacaaaaac tagaccagtt
    57841 gaatctgagg cacctggtat aatagataga aggtctgttt atgaaccatt acaaacagga
    57901 atcaaatcaa tagattcaat gataccaatt ggtagaggtc aaagagagtt aataataggt
    57961 gacagacaaa ctggtaaaac atctatagtt attgacacta tactaaatca aaaaggaaaa
    58021 gatgttatct gtatatatgt agcaattgga caaaaacgtt ctactatagc tcaattagtt
    58081 agctctttag aaaaaggtgg agctttggat tatacaatag tagtttcagc aacagcatct
    58141 gaatcagcac cacttcaata tatagcacca tatgctggag cagctatggg tgaagaattt
    58201 atgtacaatg ggaaacatgt acttatagtg tatgatgatt taagtaaaca agctgttgca
    58261 tatagagaaa tgtcattgtt acttagaaga ccaccaggac gtgaggcata tcctggagat
    58321 gtattctatt tacattcaag attacttgaa agagcagcta agttatctga tgaattgggt
    58381 ggaggttcaa tgactgcctt gcctataata gaaactcaag ctggtgacgt ttctgcatat
    58441 ataccaacaa atgttatatc tataacagat ggtcaaatat acttacaacc agagttattc
    58501 tattcaggtg taagaccagc agttgaccct ggtatatcag tatcaagggt tggtggttct
    58561 gcgcaaatta aagcaatgaa aaaagttgca ggaacattaa aacttgcata ttcacaatat
    58621 agagaacttg cagcattctc acagtttggt tctgacttag atgaagatac taaaaagaga
    58681 cttgctcaag gtgaaagaat cgttgagata ttaaaacaag gtgagcatca accaataaaa
    58741 gttgaaaatc aagttatgat aatatatgct gttataaata atcatttaga ggatattccg
    58801 atagataata tagctagatt tgaatcagaa ttgtatgcat ttgtagataa taattatccg
    58861 gaaatatcaa gaaaaatatt aggtggagaa gacttcactc atgatttaac agatgcaata
    58921 aatgaattta aagaaaagtt tgttgttgaa gtataatcct ttttaaaaaa ggaggtaaat
    58981 taattggcag gagctggaat caaagcaatc aaaacacgta tgggaactgt tgaaagtaca
    59041 aagcaaataa ctaaagcaat ggaattagtt gcatcttcta agcttagaaa agcaaaagaa
    59101 aaggctgaag attcaagaga atattttaat actttataca atacagtaaa agatattgcc
    59161 caaacaacac gtggaattag aaatgaattt ttaaaagaaa gagaagtaaa aaataaatgc
    59221 tatgtagtag tagctggaga cagaggactt gcaggtggat acaattctaa tgtattaaag
    59281 gaatctgtct ctcatatgaa aggtaaaaag gaaacagtga ttactgttgg aaagaaagca
    59341 catgaatttt tttctaaaag aaactacaat atagcaaaag atataaatag tgttgaagct
    59401 tgtggatatg aagatgcgac agaaatttca caaactatta ttgacctgta taaaaaaggt
    59461 gaagtagatg aagtttatat tgcttataca aaatttaaat ctgctttatc acaagaagtt
    59521 gaaattttga aattgcttcc attagtcttt gaaaaagata cagacgaaca aggaatggca
    59581 gtaaaagaag aaaaacaaaa tagatcaaaa gtacaatata taccatcagc agaagcagtt
    59641 ttaagttata ttgtacctca gtttatatca ggtacagtat atggtggaat tttggaatct
    59701 tttgcatcag agcaaggtgc tagaagaact gcaatggaat cagccacaga caatgcgaat
    59761 gaaatgctat ctaatttaga gttaagttat aacagagcaa gacagtcagc tgtaactcaa
    59821 gaaataacag agatagttgg tggagttgaa gctctaaaat agggaggtta ggaaatggca
    59881 aatgtaggta aagtagtaca gattgtagga gctgtactag atgttaagtt tgatagtgaa
    59941 caaagcctac ctaacttatt aaatgcgtta gtaataaagt taggagataa agaaatagtt
    60001 gcagaagttg ctcaacatat aggtgatgat actgtaagat gtatagctat gagtgcaaca
    60061 gacggacttg taagaggtat ggaagttgta gatacaggag ggccaataag tgttcctgtt
    60121 ggagatgaaa ctttaggtag aatattcaat gttcttggaa aaccagttga tgggaaacca
    60181 gctccaaaat ctgcacctaa attacctata catagaccag caccagcata tgatgaacta
    60241 gaaactacag cagagatact agaaactggt attaaggtag ttgacttact agctccatat
    60301 ctaaaaggtg gaaaaatagg tctatttgga ggagcaggag taggaaagac agttctaata
    60361 caagagctta taaacaatat tgctaagcaa catggtggta tttctgtgtt ttcaggagta
    60421 ggagaaagaa caagagaagg taacgacctt tatggcgaaa tgagtgagtc tggagttata
    60481 aataaaacag ctctagtatt tggtcaaatg aatgaaccac ctggagcgag aatgagagtt
    60541 gctttaactg gacttacaat ggcagaacat tttagagatg agcaaggaca agacgtttta
    60601 cttttcgttg ataatatatt ccgtttcaca caagctggtt cagaagtttc agcacttcta
    60661 ggacgtatgc catcagctgt tggttatcag ccaacattag ctactgaaat gggtgcactt
    60721 caagagagaa taacatcaac taagaaaggt tcaataacat ctgttcaagc agtatatgta
    60781 ccagcagatg acttaactga cccagcacca gctacaacat tctctcactt agatgcaaaa
    60841 acagttttat caagacaaat atcatcactg ggtatatatc cagcagttga ccctcttgaa
    60901 tctacatcaa ggattcttga ccctagtata gtaggaaaag aacattatga agtagctaga
    60961 ggtgtacaat caatacttca aagatataaa gaacttcaag atataattgc tatacttggt
    61021 atggatgaat tatctgatga agataagtta atagttgcac gtgctagaaa gatacaaaga
    61081 ttcttatctc aatcattcac agttgctgag caatttacag gaaatccagg tcaatatgtt
    61141 cctgttaaag agactgtaag aggatttaaa gaaattcttg aagggaaaca tgatgactta
    61201 ccagagtcag cattcttatt tgtaggaaca atagaagacg ctgttagaaa agcgaaggga
    61261 agtatgtagt catggccagt gaattttcat tgaaagttgt aactccaagt aatacttttt
    61321 atgatggaga tgttgaaatg atagtagtta gaactacaaa aggagacaaa ggggtgttga
    61381 aaggtcatat accatttgtt tcaggtatac ctgtaggaac tttaaagata aaaaaagagg
    61441 gaagttttaa agaggcgaaa atagcagaag gattcattaa tgtaactcaa gataaaactg
    61501 tcatattgac agaatctgct gagtggattt aataaattaa tttagagtat aaaaagtcat
    61561 tttgaccaaa aaaacttttg ggtaaaatgg cttttttgcg ttttggtgtt aataaaataa
    61621 cgataaaatt gtaagttttt agtgataata aattcacaaa atgtttaaat ttactgccaa
    61681 attatgttgt aattaataag ataaagaaga tttagatagc ttttatgtaa gtgaaaaagt
    61741 cttcatataa gaaatacata taaaattttt ataaaattta aaaaatttgc ttagttgtgt
    61801 agtataataa ataatataat agatttgtat ataatattca ttacaaataa ttttaaaagt
    61861 tacagtttta ttataatgat tattaaatta agataagtaa cataaactaa ataataatgt
    61921 gtattatcga tagtaaattt ataaattcat tattaattat tgaaagaagt attataaatt
    61981 ttctggagga acaatgaata tatttgatat tggcgtagat ataattgaaa ttgatagaat
    62041 aagaaaggct gtagacaaaa ataataggtt tttggagaag atatttacag atagagaaat
    62101 agagtatttt aattctaaga attttaaagc agaaagtata gcaggtaatt tcgcagccaa
    62161 ggaagctata agtaaatcta taggtacagg aattagattg tttaatttta aagatataga
    62221 agttctcaga aatgaaatgg gaaaaccaat agtaaaaact tataataatc tagcaaaaat
    62281 gtgcatagat tataatgttt tagaaataaa agtttcaata tcacattcaa aagattatgc
    62341 tatagcaaat gcgataacca taattaagga ctaaggagtg attacattat gatggataaa
    62401 acagcaaaag aaataatgac aacagatgta atagtagcaa aacaagatga tagtatagca
    62461 gatgtagcta atatgctaat tgcagaaaaa ataggaggtc tgccagttgt agattcagag
    62521 aatagagttg ttggaataat ttctgaaaca gatattctta aaaaagaaaa atatatagaa
    62581 gcacctctct atataaatct attacaagga ttgattttct tagatgactt aaaaaaagtt
    62641 gaaaaagata taaaacaagt agctgcttat aaggttggag aacttatgtc taaagatata
    62701 ataaaggttc atgaagatga taagtttgat gatgtagcta atgtaatgat taaaaaatca
    62761 ataaacagag ttcctgtagt agatgatgac aacaaactta aaggtataat ttgtagatat
    62821 gatataataa aagctttata caatgaataa actgaagtag gaggtgtgat gtgagaaaaa
    62881 agtggaccat agtatgtatt atgttcttgg cactggttat aattgtaata ggatgccaaa
    62941 aacgacagtc cacaaaagaa gaagtataca aagattttca aaagcagatt tctgatatga
    63001 attattacag ttgtaaagct gaagtagaag tagttggaaa taaaagccca cacaattatg
    63061 ttttaattca tacttataaa aaaaccgata actataaatt agaagtaatt tccccaaaac
    63121 atttaaaagg gaaaagtata gaatatcaag atgataaaat attagttaaa aatccaaaga
    63181 ttagtgatgt agtggagtta cctaatacag gaaaaaataa tcaatatctt tttgtaggag
    63241 actttataaa aaactatctt caaaatgagg agatgaaagt aaagttatcc aaaggacatt
    63301 tggttttaga gacttttatt cctggggata ataaatattt taacaagcaa gtattatatg
    63361 taaatgctga cacaaaaaat cctgaaaaaa tggaagtgtt agataaagag ggagtgccaa
    63421 gatttacagt aaaatacaaa gattttgaat acagaaacta agggggacta aagacatgca
    63481 aaaaataaca gtgcctacat gggcagagat aaatctagat aacttaagat ttaacttaaa
    63541 taatattaaa aatttattag aagaagatat taagatttgt ggagtaataa aagctgatgc
    63601 atatggacat ggtgcagtag aagttgcaaa attgctagaa aaagaaaaag tagattactt
    63661 agcagtagca agaactgctg aaggaattga acttagacaa aatggcataa cacttcctat
    63721 tttgaacttg ggatatactc cagacgaagc ttttgaagat tctataaaaa ataaaataac
    63781 tatgacagtt tattctttag aaacagcaca aaagataaat gaaattgcaa aatctttagg
    63841 agaaaaagcc tgtgttcatg ttaaaataga ctcagggatg actagaatag gtttccaacc
    63901 taatgagaag tcagtacagg aaataataga attaaataaa ttagaatata tagatttaga
    63961 aggtatgttt actcattttg ctacagctga tgaagtaagt aaagagtaca cttataaaca
    64021 agctaataat tataaattta tgtctgataa attagatgag gctggtgtaa aaatagctat
    64081 aaaacatgta tcaaacagtg cagctattat ggattgccct gatttaagat taaatatggt
    64141 aagagcagga ataatattat atggtcatta tccatctgat gatgtattta aagatagatt
    64201 agaattaaga ccagccatga aattaaaatc aaaaatcgga catataaaac aagttgaacc
    64261 aggtgtagga ataagttatg gactaaaata cacaactaca ggtaaagaaa caatagctac
    64321 agttccaata ggatacgcag atggatttac tagaatccaa aaaaatccaa aggttcttat
    64381 taagggagaa gtgtttgatg tagttggtag aatatgtatg gatcaaataa tggttagaat
    64441 tgacaaagat atagacataa aagttggaga tgaggttata ctatttggag aaggcgaagt
    64501 tacagctgag cgtatagcta aagacttagg aactataaac tatgaagtgt tatgtatgat
    64561 atcaagaaga gttgaccgtg tttatatgga aaataatgag cttgtacaaa taaacagtta
    64621 tttgctaaaa taaaaccatg atattataat ctgggaggcg attttgtgta cgataagagt
    64681 aaagaaaaaa tagaagttac tttacctgac tctctgattt ctgaagttga tagtatagtt
    64741 cagatggaga acagtaacag agaagatttt gcaaaagctg cttttcagtt ctatataact
    64801 cagaaaaaga aaattcatat taaagaatct atgaaaacgg gttatagaga aatgggtcaa
    64861 attaatctgt cactagctga attaggtatg acagttgaag aagtatcttc tgatgataaa
    64921 aatgaaggga agattgccca aggtgagtac taattgtgaa ataaagcgtg gtgatttata
    64981 ttacgctgat ttaagtccag ttgttggttc agagcaggga ggcgttagac ctgttctgat
    65041 aatacaaaat gatgtaggta ataaatatag tcctacagtt atagtatcag ctataacatc
    65101 tcagattaat aaagccaaat tacctactca tgtagagata agttccaatg aatatgggct
    65161 taataaagac tcagtaattc ttttagagca aattagaact atcgataaaa agagactgag
    65221 ggaaaaaatt ggttgtctag atgaaaatat gatgataaaa gtagatgatg gacttcaaat
    65281 aagtttagga ttgtttactt tttaaagagg gatttgtctt ttattagaca atcccttttt
    65341 tcttttaaat atctcttaag gtttaatttt aatgtactat gttaataaaa ttaaaaataa
    65401 cgcaaaaaaa tagcataaaa gtgatataat aatatggaat tgatataaaa ttacgaactc
    65461 aagggaggta attgcatgag agaccataaa ggattaaatg agattgcgcg tatcataaga
    65521 agagatatag tttcaatgat acatagagcc aaatctggac atccaggagg gtcattatca
    65581 gtagttgaaa tacttactgc gttatacttt gatgaaatga atgtggattc ttcaaatcct
    65641 aaaatggagg atagagatag atttgtatta tcaaaaggac atgctgcacc agcattatat
    65701 gctacattgg ctgaaaaagg ctattttgat aaggaagaac tgaatggatt aaggaagata
    65761 ggaaggatgt tacaaggtca tccagacatg aaaggcacgc caggtgtgga aatatctact
    65821 ggttctttag gtcaaggttt ttcagttgca tgtggtatgg ctatggcatc aaagttggat
    65881 aatgctccgt ggaatgtgta tactttgctt ggtgatggtg aggttcaaga aggaattgtt
    65941 tgggaagctg ctatgagtgc tgcacattat aaacttgata atttaattgc ttttttagat
    66001 aataatggac ttcaaataga tggagatata gaaagcgtaa tgagtttagg ttcaatagtt
    66061 gataaattta aagcttttgg ttggaatgta attgagatag atggacatga ttttgaccaa
    66121 atatttgcgg ctcttgatat agctaaatca acagttaaaa aacctacaat gatagttgca
    66181 aaaactataa aaggcaaagg aatatctttt atggaaaatc aagcaggatg gcatgggaca
    66241 gctccaagtg atgaggagct agaaaaagct ttgcttgaat taggaggtgc tgacaatgag
    66301 taaaatggcg acgagagaag catatggtaa agcattagta aaattaggtc aaataaatga
    66361 caatgttgta gtattagatg cagatttatc aaagtctaca aaaacacatg atttttacaa
    66421 gtcatttcca gatagatttt ttaatatggg tatagctgaa caaaatttaa taggcgctgc
    66481 ttgtggatta tcaactgctg gtaaaatacc ttttgcaagt acttttgcta tgtttgctac
    66541 gggaagggct tttgagatta taagaaattc agtttgttat ccaaagctaa atgtaaaaat
    66601 atgtgctact catgcaggtc ttactgttgg agaggatgga gcatctcatg aaagtgtgga
    66661 agatattgct ataatgagag ctataccaaa tatgacagtt cttgttccag ctgatggagt
    66721 tgaaacagaa aaaattattt ttgaaatagc taagtataat ggacctgttt atgttagatt
    66781 agggagaagt tcagtaccag ttttatttga tgaagattat aaatttgaaa taggaaaagg
    66841 tacagtctta agagaaggaa aggatgtatc aattatagct tgtggaatta tggtaaatga
    66901 agctctatta gcacaagaaa agttgcaaga agaaggtata agtgctagag ttataaacat
    66961 gtcctcgata aaacctatag acaaagattt aatattagaa tcagcaaaag aaacgaatgc
    67021 tattgtaact gtagaagaac atagcataat tgggggatta ggttctgctg taagtgaggt
    67081 agtaggagag tcttgtccaa ccattgtaaa gaaagttgga attaaagata catttggaga
    67141 atctggtact ccaaatgaat tgttaaaaaa atatgaatta acttgtgatg acataataaa
    67201 gactgttaaa gaagttatta ttgcaaaaag aatgtaagag atataaatta ttcatgtttg
    67261 ttaataatat aatatattta aaagagaggt ataaagtgtt atattaattt atatctctct
    67321 tttttttata tgatatcaat atatcaaaaa tgtaataaaa tattcaaatt tttacaaaaa
    67381 tagagaaaat attcaaatat atattgacta ttcagaaaaa tatgactaat atataattta
    67441 tagagaaact aattttatat ataatgacta cttagataaa agaatctaaa aaaattatga
    67501 gaggaggagt agggtataaa atcagattat aagttttaag ttattatact aaaaagctat
    67561 aaaacagtta tcatgtattt tatgttaaag gaaattgtag gtagtttatc gaattgttta
    67621 atcagaagaa aaaatttcac atggggaggt aactgagata tgtcagaaaa agtaaatgtt
    67681 aaaacagtca tcagtttcgc aggtgcgtat gtagcaacag taatcggttc tggatttgca
    67741 acaggacagg aaataatgca attcttctct ttttatggtt ttgcaggtat tattggtggg
    67801 ataatttcaa tggtattatt ctcatggatg ggtgcttcag ttatgtcaaa aggtaaagag
    67861 cttcaactta aagaacctat caaaatttat cgtgtttatt gtggtaagta tttaggaata
    67921 ttctttgaat ggtttggacc tttattctta tttggtgttt tcgtagtaat gatttcagga
    67981 gcaggagcaa ctttaactga atactatgga ttaaatccat ttgtaggtag agtaggtatg
    68041 gcagtagtag cattattaac tgtttcacta ggtcttgata aattatcaaa gatactaggt
    68101 ggaatagggc ctataataat aatctttaca cttttagttg gtggtataag tttagctaaa
    68161 aacataggta atataggaga agctgcacaa gttcttagca ctgtaaagat agctaaacca
    68221 gttccaaatg cctatctatc tggtgtaata tatactactt ataacacaat tgttgttatg
    68281 gcattcttaa ctggattagg agcaagtgct gctaacaaaa aagaagctat ttgtggtggt
    68341 atattaggtg gagtagcact tatggctgca gctataatga tgcacttagc tattctttct
    68401 gatataggaa acttatattc aaaagcaata ccatcattat tcttagcaga taagatttca
    68461 ccagtaattg gagttttatt ctcaataatt cttatattag gtatatatac aacagctgta
    68521 cctttattat ggtcagtaac taatagattt gtagatgata aacatcctaa gtttaaatta
    68581 ataactttaa tagcagctat attaggtctt ataggtggct tcctaccatt tgataagctg
    68641 gttggtattt tatatccata tactggatat atgggcgtca taatactggt ttgtgttctt
    68701 tatagacaga ttacaaaaac atctggatat caagaaggaa tcagtgacaa ataagtattt
    68761 tttaatattg taaactcaag agctatatga aaacaatgaa aatgttttca tatagctctt
    68821 tttatttttt agctcgttta ttatgaaata gaaaaaacat gttttttagt tacattacat
    68881 atatttataa ttatgtataa atatatacta atcaataatt tagagtctaa gataagttta
    68941 taaatcatat atttagaata tatgggagga gtgataagat tgaatgtaaa gtttaatatt
    69001 aaaggtataa tttatggagt tatagctctt gtattcgtta tagggggatt tatattcata
    69061 ccaagtatgt ttgtagagaa atctaaaccc atagattata cagtattaca aagaaattca
    69121 ataccagaaa agatattaga tgtgatggat aagtatacaa atgaagaaag agcattagcg
    69181 gctaaaatcg ataacaaaat atacattata gtgactagag gaaataataa atatggtata
    69241 gaaatggaca aaatagaaag tgtggttgag gaaggaaagg atgttttgag agtcaagata
    69301 aagtataaag ataaggaaga ttcttttcca tacatagttg ttgaaacaaa tatgagtgaa
    69361 cttccagata gaatagaatt aaatgcgacg aaataagaag gtattttata attaaataac
    69421 tgcatattgt acaataaagt catggttttt attaatgtaa gtaaattgta tatggttctt
    69481 attgttgtaa aagccatgac ttaaaatgct tataaagtaa gatattaaca gtagtattta
    69541 ttactatatt aaatggggtc tggaaatact taatattcta attatttgga gtgataattc
    69601 tagtttcagt aactatgtag tctaattgtg catcatgagt ttcttttgga atagaatcga
    69661 atatctggaa gtcaaatgct atgccgatag ttatagcatc ttttcttaag ttttctaaaa
    69721 atctatcata aaatcctcca ccatatccta atctatagca atgtatatca tatgctacag
    69781 ctggtacaat tacaacatct aaggccttaa tatcaattgt aggtgatttt tcgttaggtt
    69841 ctcttattcc atatgctcca attctcaatc cctcttttaa atctgttatt tgagtaggga
    69901 ttaatgtatg attttctttt attgtgatgg gacttgatac tattttcttt agagacaaaa
    69961 gttttttgat taaattatct gtttgaactt cattgttaaa atttagataa agcattatat
    70021 tagttgcatt tcttatatct tccatttgaa gtaatttttc agtgattaaa tttgaattac
    70081 taagtacgaa gtttgcactc ttattttttc ttgattcaat aacttttttt ctaaattctt
    70141 ttttcataaa ataattcctc ccttaatatg ttataatgtg tacagcaatt gtatttaata
    70201 taaattttag tataatttat tgtaataaag caatatattt gggtaaatgt aataaaaata
    70261 acagctagtc atataataat aatagtttat gtaaaaggag atgtatcttg tgatttcaaa
    70321 gaagaaagct atttttttag gggtgatttt agtaattata acagctatgg ttacatcagc
    70381 atttcagttg acattgggga ataaagttgt aatatcgaaa gaactctatg aagactataa
    70441 aaaatatgat aagttgttag gactagaatc tattataaaa caagattttt ataaaaaagt
    70501 atcagatact gatttggtaa atggagcagc aaaaggtcta tttctaggaa caaatgataa
    70561 gtattctggt tattatacta aagatgaaat ggagaatcta attaatgata gtgaaggttc
    70621 ttatgttggt gtaggtatgt atataggggc atcaaaagat ggtggcttag tagtagttcc
    70681 catgaaagat tctccagcag agaaagcagg tgtaaaatca ggggataaat tagtaaaagt
    70741 caatggaaaa tctgtctcat ataaaaattc agatgaagct gttcgtatga tgaagggtaa
    70801 aaaaggtaaa acagttgaac tgactatatt aagagaagat aaacaattga actttaaagt
    70861 aaaaacagac cagataattg agaagagtat agaaagtaaa gtaattgata atgatttagg
    70921 atatatagaa attacccaat ttatatcaag tacatatact gactttgata aagctttaaa
    70981 agaattaaaa gcaaaaaata tcaagggatt agtaatagac cttagaaata atcctggtgg
    71041 aatgctagat atatgtaaag aagttgctga tgagttaatt ggtgaaggaa ctatagtata
    71101 tacaaaagat aataagggaa atactgagta cttgaaatct gataaagaaa aattgggact
    71161 tccaatagta gtgttaacta atggagaaag tgcttctgct gctgaaatat taacagctgc
    71221 aatcgttgat aataaagaag gtatttctgt agggactaca acttttggta aagggttggt
    71281 acaatcagtt gtaagattga aggatggaac aggatacaag ttaactactg ctcaatattt
    71341 tacacctaat ggagattata tcaatgaaaa aggtataaag cctactattg aagaaaaaga
    71401 tgaaaataaa cagttagatg tagcaactaa gtggcttaga gaacagattg ataaatagga
    71461 tttaattttt ataaacttat actataaaat aaagaacatt ataaaagaga tgtctcaaaa
    71521 tgaacttttt agttcatgag ggagtctgga aatatttatg tgtattcttt aaataaaaat
    71581 ttatttttta agtgataatt aaatttttac agacagggct atggttttaa aaatcata
//
LOCUS       DAEHWM010000005        67305 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.005, whole genome shotgun sequence.
ACCESSION   DAEHWM010000005 DAEHWM010000000
VERSION     DAEHWM010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 67305)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 67305)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..67305
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.005"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(195..1373)
                     /locus_tag="KNP36_000383"
     CDS             complement(195..1373)
                     /locus_tag="KNP36_000383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872280.1"
                     /translation="MQELKPVARISKSKLKDILDVFKTSIRKVEKIDYSACNSCAIKN
                     NPSFDSHKLNEFCSNCPKLKTISEFSYVTEKETELGTIEIVTNESKCMALSKSAIKQY
                     LAYHFIVSNKNYVRKAVSFQNIADICNVSIVTARHNHNVLLRVGLVYSTEIKRGKFDI
                     VIDEEYKNHLKKEDGGKGYLTMSLDTLNHLLSFENVNELKLEIKKLIWADAKGSKLGK
                     RIRFKKDNLISILPEYIKKSNKRTEAFLRSSKTLFDVSNDTIDTKRYETKETISEKYT
                     EPIRIQISKFFDNTGCSLSSNYSKVLSQINLDRYNLFEEDLRSKLDMEKDIIINDLVG
                     LSVQYGVTRVLAALDYMFNKYTVDEEDINYNEIRNPGAFIRTLIVQSINKNGSLAIAI
                     "
     gene            complement(1449..1715)
                     /locus_tag="KNP36_000384"
     CDS             complement(1449..1715)
                     /locus_tag="KNP36_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain containing protein"
                     /protein_id="HBF0872281.1"
                     /translation="MSLKYKDKEFVLVEKKNINELDNSNIKYIDLKDKQYYVVTQGKK
                     PKRFNLEDIKNIKKDLDNGISLRKCATKWNCSTRTIQDIKNNIY"
     gene            complement(2189..3757)
                     /locus_tag="KNP36_000385"
     CDS             complement(2189..3757)
                     /locus_tag="KNP36_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872282.1"
                     /translation="MSKDVKENISNEQKDLNKINLIYHIIYDNDRFKMITRKYFEIFR
                     LKGMSAEEISLKFEEFLYSLISDKFKKINTVNDVKKLRNQENSSSLKLKKRWSDMTLD
                     SLSEDTKSSRKKSSKYLKKELEIVESEYLKNGRIISAGVKNPKELKEQRKDFLDEWKS
                     SSSYNICDYPYLQELSTSKINSAFIHDILMCITEVLKDDYDFDINKIAIKTPPHISPG
                     IFLPFTKGKRYSHLNVKKNENEYMSDDYSAKNLSGKQMNFFYKFSIGQDENIENLKLE
                     LINPDTEKRALPKIYLDKQDLEIIRFVYTYSHMNSFSFYLGDLVKYLGLSDGKKNYIN
                     IKNRLLKLPYYTFYSNQTNDKGELKYEISFNLFSSTTIVNDENNNNRELVKITKSFIE
                     EVERVNTDIMYRNELEKLQLTQSINLAYFLEGRRSFLISCGEDIKNKSFRYDIEDLKF
                     DVHLNKSKTVKQNMEYLELGFNEIKENQFIIKDYKRGNSYFDVYFYEDFEKRKRLINN
                     TILSLPDYMIENKS"
     gene            complement(3762..4688)
                     /locus_tag="KNP36_000386"
     CDS             complement(3762..4688)
                     /locus_tag="KNP36_000386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872283.1"
                     /translation="MNYNLKNENVLSELLQNEDEKTRIGILKVYKVLIFWFAKEGKLV
                     EEENDYIVEIVGNDKEEIVRDMSQNKTYNAIMAIIFKINKIFKTLNYDIHFSKPKNLV
                     AEFDLSKYLTQDEVLQVCSKLTNAQDKFIIYAAFCGLIGKDAEDLRGIKIKDIDLEKR
                     LIKLKDTEFKLDKFLFDFTKDTLEQKEYKQYLEQDSNAAEFYLFNSNSEYLIKTKPDA
                     RYGNGLKEMGYSTIRKRLLIINDYLDNKVQLNFTNLKISGIMHQMHLNEKKYTQSGYW
                     TNKSLKEFKEDNNLNFKIQEVLSIYKQKYIKE"
     gene            complement(4821..5393)
                     /locus_tag="KNP36_000387"
     CDS             complement(4821..5393)
                     /locus_tag="KNP36_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase"
                     /protein_id="HBF0872284.1"
                     /translation="MTWNDLKNNDITYIVEYINNKLNNSKSLTKVAIGLGVSESSIRK
                     YLTKRGYKRINDEYVFIGDNSMTKVVNNRQQSNNDNTFNMTIEDDNNHNIVIDNQFKN
                     NIVSLAKDYDKIQDVLNWFENKEDTNVIEVVQDGIKIDLHSKDAIRTTVRLNKDAWNL
                     FDEFCGKFREFNKSDLMSMALLEYIKKYDK"
     gene            5589..5771
                     /locus_tag="KNP36_000388"
     CDS             5589..5771
                     /locus_tag="KNP36_000388"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872285.1"
                     /translation="MLKTLFILLAVFVIIKLSILIFKDALKFLNMFESKNESFIGWLF
                     LCILALVIYNLIDIIL"
     gene            5967..6266
                     /locus_tag="KNP36_000389"
     CDS             5967..6266
                     /locus_tag="KNP36_000389"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872286.1"
                     /translation="MVIKVNFGGNYSPDYIYVPNEISLKKYEIRNEFHIWIDNTEDEH
                     PFWCYENGVQIGLHYRGDAIVYWLNNYILKNANDKARLIESFSNKKLDYDLIINL"
     gene            complement(6508..7224)
                     /locus_tag="KNP36_000390"
     CDS             complement(6508..7224)
                     /locus_tag="KNP36_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBF0872287.1"
                     /translation="MNILIENKFIEKLKYTKNIPNSLYKDLRHNFLFHSNKIEGSTFT
                     SESLQDLIEHNIVKGDHTLDDVITTVNSSYVFETVIDTLGEYLTEKYIKDLHGQLMYN
                     SNIHNMGLSGIYKKIPNRIIGTNSVLAQPFEVEPKMLELIEWYNNLKDITLKDLAEFH
                     YRFEIIHPFQDGNGRIGRFILLKQILENNLKLIIISSDTVDDYRQALKGCHNEYYKPL
                     EQYFESLDDYKEKNKDLWSF"
     gene            complement(7502..8311)
                     /locus_tag="KNP36_000391"
     CDS             complement(7502..8311)
                     /locus_tag="KNP36_000391"
                     /inference="COORDINATES: protein motif:HMM:NF022027.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HBF0872288.1"
                     /translation="MNKLKVKGKQKFMNLEIPVIEGGFGEDKKCMTDKTISEIHNQPN
                     FKIRERIKDNIKRFKEDIDYIDLKVIRDTDDNLELLQTLGYSKMQISKADNIFLLSER
                     GYSKLIKIMDTDLAWEIHDKIMDEYFSMRKKLNDPFENLSPELKVIIKLEQRQAELES
                     GQHELEEKVNVLYDFSTIDYNQQETIRSLVNRMVIQVYQCLNFSAYEDAKLRKRVYFS
                     LWKDYRKKFGVNSYKNTAKKNYDNAIKFIENWEPNYDLSNEIYMFQKVENI"
     gene            complement(8482..8712)
                     /locus_tag="KNP36_000392"
     CDS             complement(8482..8712)
                     /locus_tag="KNP36_000392"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872289.1"
                     /translation="MNNNDKLSILNQLEYIENDIDARNEMIEKFKDLLVKYPKSRDIR
                     RYIKQQTQFLNGIRYIYDNLDILKNMINNDKK"
     gene            complement(8705..9226)
                     /locus_tag="KNP36_000393"
     CDS             complement(8705..9226)
                     /locus_tag="KNP36_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872290.1"
                     /translation="MKFKNIVMGMLLGLIIVGVSGVTKVKAAELDNFYIESTDRVIEV
                     LEDESIVLYDTKEQVYNFYPICMGDWNYSFKNKKDLDSAVATYKELSSNINHLSNIYV
                     VNKLNDNGNIKVFLNDGSSIVYIKQDNKYYFYPSCMGDWYLTLDSKIYLTNCINTYIE
                     YYYSLSTGGGTNE"
     gene            complement(9530..10114)
                     /locus_tag="KNP36_000394"
     CDS             complement(9530..10114)
                     /locus_tag="KNP36_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872291.1"
                     /translation="MNEYILISYTKGEGTCDHCGRTIKNIATIKNNVTGEVFHVGLTC
                     VEKIMKLNVTFYKALSREIKKHYKCMEYYSKGLDIETNLNKIVKNNTKYKEGSYAYKS
                     NEQMLEDAIAEVAWSLARMIDSCMRMNKLSKSGLIDIDILNSLFIKYKEYMSKFDENY
                     NKNKYKYKSCYTMKPLKVILDENEDLKELYKSMQ"
     gene            complement(10152..10415)
                     /locus_tag="KNP36_000395"
     CDS             complement(10152..10415)
                     /locus_tag="KNP36_000395"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872292.1"
                     /translation="MLANQIKGIKTSLETSSLRELKGYIKDLRKALSGYKYKNKIDEI
                     TEYQIDKLCYKIDNTDIFDLKYKEIEKYIDSLILILDFIFMEM"
     gene            complement(10441..10986)
                     /locus_tag="KNP36_000396"
     CDS             complement(10441..10986)
                     /locus_tag="KNP36_000396"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872293.1"
                     /translation="MKKIANLNKEELKIIWEKNSQLREDVRKACEDNDMYWIDEILCH
                     LNKSLDDWSIGFYNDNYIKIEDNHKFLLELKSVCEKFSFLSEEEQRPLEYAISLIDKL
                     HCMDFENKRFNMLENKINNMVKKLEEKVIEEFNKMTEPLDKEYLLENFIEFYVEAYLN
                     DNEFYIDNEYVLYEKIIKSYA"
     gene            complement(11123..11419)
                     /locus_tag="KNP36_000397"
     CDS             complement(11123..11419)
                     /locus_tag="KNP36_000397"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872294.1"
                     /translation="MKKIINGYSIYKDGTWCEVIKEGKFIFAGSVNEKLSYEDIYIAL
                     TAKLEFRLHGKLLLSYSLYGTFQGEKQSTLELLAYENNCNINDIEVKQVVENIQ"
     gene            complement(11453..11638)
                     /locus_tag="KNP36_000398"
     CDS             complement(11453..11638)
                     /locus_tag="KNP36_000398"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872295.1"
                     /translation="MQELCSMGLTYPFDFGRGKGKYQTNIDEETIYKRAKENTKIQEY
                     SKKYLNYIAKIKKSISK"
     gene            complement(11778..12473)
                     /locus_tag="KNP36_000399"
     CDS             complement(11778..12473)
                     /locus_tag="KNP36_000399"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872296.1"
                     /translation="MNKIIVFYDIEGHPGFQVLVRNVKKYTRQNIIFELVEDYIKNNI
                     GEIDLKDEKIYSSVSWKVWTISDVAIYNTLFDLRLDYNKLIESEEEDTDNKECVKELF
                     CMGKGCKWMETVLLLRQNKIDSSQYNILTINNYTYVKTWAEQCKKILLANNYSKVFKF
                     NEIMKDCDNNLIGDICFKYNNKEYKHKFTFNIKKDKLVNIDCEYKIPFLRYVFNDIEK
                     FLTRYSENISNLK"
     gene            complement(12753..12893)
                     /locus_tag="KNP36_000400"
     CDS             complement(12753..12893)
                     /locus_tag="KNP36_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872297.1"
                     /translation="MKKLIIKIKSLFKKDLDSSYWSTTESIILKCGNSNQLELLEQAN
                     KL"
     gene            complement(12961..13674)
                     /locus_tag="KNP36_000401"
     CDS             complement(12961..13674)
                     /locus_tag="KNP36_000401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HBF0872298.1"
                     /translation="MLNIYITNLGKYNEGELIGEWAEFPVNEEELEEILDRIGINEEY
                     EEYFITDFETDIEGLEISEHSNIEQLNELAKELEELEEYEIEQLKALLGCGYIDFYDM
                     LEGDICRLSGNYTFIQLDDRSPLDDENLGRSYIEEICCGDLSCIENIAYYFDIEAFSR
                     DLRFDRDMIIENLYEEDIEYYENMTDIEFAENYIERLGDIEELGQETLERYFNYELYG
                     TDLRYENICIASNYLAIVS"
     gene            complement(13795..13983)
                     /locus_tag="KNP36_000402"
     CDS             complement(13795..13983)
                     /locus_tag="KNP36_000402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872299.1"
                     /translation="MYEQRKAKVIFNKGAGNSRGESYTNRVTIPTTWIKHMDITKLDR
                     EVLLTFDGNKIVIEKIDE"
     gene            complement(14078..14311)
                     /locus_tag="KNP36_000403"
     CDS             complement(14078..14311)
                     /locus_tag="KNP36_000403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872300.1"
                     /translation="MDEKTLELLREIQESIKILNDKLDEFDYTQDKIKSNVEGLLECF
                     SRIDFRIEDLENGQTSLYTKLDIVQNETAKSIK"
     gene            complement(14323..14646)
                     /locus_tag="KNP36_000404"
     CDS             complement(14323..14646)
                     /locus_tag="KNP36_000404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872301.1"
                     /translation="MDEKILELLQKMDTSINDIQGEIKWINTRLDSMDGRFDGIENQL
                     SDLKEGQEEIKKKLDLTYNQVARNMEGITEVGEKIDTLKNDMNFVEMATSKNWNEIAK
                     LKSIK"
     gene            15375..15686
                     /locus_tag="KNP36_000405"
     CDS             15375..15686
                     /locus_tag="KNP36_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872302.1"
                     /translation="MNRLKEVRKERGYNIQEIADKLNVAYNSVLRWENGNRKIDIDKL
                     VELSNIYNVSIDYILCKTDLKENIQLKEEEVNLLDNYRELDTKSKTIVQEQINTLKKL
                     L"
     gene            complement(15900..16091)
                     /locus_tag="KNP36_000406"
     CDS             complement(15900..16091)
                     /locus_tag="KNP36_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872303.1"
                     /translation="MKLEKLIDIRKEKKYSQEDIARMLDISLRNYHRKEKGENQFTVS
                     ELEKICSYLDIESKELLDI"
     gene            complement(16344..16502)
                     /locus_tag="KNP36_000407"
     CDS             complement(16344..16502)
                     /locus_tag="KNP36_000407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872304.1"
                     /translation="MRITKGKIKELIELCHQLEKLFVQVFKSLEHILISLCSCIGWLL
                     ILIYIIKH"
     gene            16998..17186
                     /locus_tag="KNP36_000408"
     CDS             16998..17186
                     /locus_tag="KNP36_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872305.1"
                     /translation="MESGLFVSRILCVVLSFPHFKKIADGFTDEIALYFPHKTNIYLK
                     IFLRFLLLNYILNKENIK"
     gene            17608..18522
                     /locus_tag="KNP36_000409"
     CDS             17608..18522
                     /locus_tag="KNP36_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParM/StbA family protein"
                     /protein_id="HBF0872306.1"
                     /translation="MEENYQVIGLDIGRGYVKGYSKYNGMVKECLFKSVFGDGRNIDF
                     EKYENPIYIDFESVSYFVGSLAEKESITPIRNSDDSKVSFTMRILVAAALNEIAVADE
                     VKLMMGVPYKSFRKTTLKEVVDTYKGKTFKVKDKIKGGHKEIKISDISIFREGDAALF
                     HTLEGKVNEDKAVGMVSIGFRSTEMSFFEKGFVFNDKLSDTLEAGNQDALTMVQKQLK
                     DRGIIRELNEIDSSNDYDELKKVAYIMASESTAQRISSKWKNIDEMDVYVSGGTALHM
                     TFDNRFKVSKDAQMATAKGLFEVGMEQF"
     gene            18535..18807
                     /locus_tag="KNP36_000410"
     CDS             18535..18807
                     /locus_tag="KNP36_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872307.1"
                     /translation="MKKSSSFYLEEDIFGEIEKYQNDKNISSRNTALERIILEWKNLQ
                     EENKLLKQCLGNGVYRTNKKTNVTEEKKDIKRENPIIKNIFNNMPD"
     gene            19079..19942
                     /locus_tag="KNP36_000411"
     CDS             19079..19942
                     /locus_tag="KNP36_000411"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872308.1"
                     /translation="MKRGEVLEIGKRKKSFSPEQRAIINNKKELPYHNFKLGGFVFCT
                     YVKNELLFNEVNISKANISRLIYLATYLNYNTGEENLLVRYSQFKEMIPIDRKNMREI
                     LNLKDRAFRNFLADVKKCELLYESNNKFYINPKYFTKGIPNFENKEYTRIYINTSRFL
                     FEHCTPRQHKQLSYIYQLIPYIHFESNILCLNPHETDISKIKKISLYKICQLLNISTI
                     KQDMNKFKKELLRFYIKVEDDKYYFFKYVIVEGNNKNTDYFIINPCVIWKGNNLNLAK
                     KTIDLCFFNCI"
     gene            20120..20368
                     /locus_tag="KNP36_000412"
     CDS             20120..20368
                     /locus_tag="KNP36_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872309.1"
                     /translation="MKEKKIELIYLEDLDESEKTGVHKNRYQILNEEYEQMIDTYTEM
                     SKRSSYDIVNERHKEDFKDELWDYDDTDYDDGLQGKEV"
     gene            20371..21813
                     /locus_tag="KNP36_000413"
     CDS             20371..21813
                     /locus_tag="KNP36_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872310.1"
                     /translation="MIYNNNNFYEEIDGKSAQDYIKNLDYSIDNSKDRIKYIEERLGV
                     KHTWFEESNRNYIDTFYNTLTKRNENIITRVKYQEKKQFNDKFWENIFEQTSDSPLDK
                     DGVYYVTIDGEEVVMDYNRFITWCGYNQINPIEYINVKNPFSNSNGTWEYTHHNTSKI
                     KLILNKDDSIYSTSNIAKTLEIMGSYILSVDDKPKETKIRIYNSKELFNRACQEEALL
                     NKIAPANGGNINSNTSNKDGFLEDNSFAFFQLPKNYKKIKDIKVKPKDIKKYPIIKTY
                     SDTYEWYKAKYKELGHKQLSKEELKLKRMVRKNLNALKNDMTDVKNSIERPIIWKAPL
                     ADAGSPEWDYLDMFDKSHVKELLRIQKGNDLQDDLTCIVMDLNNIISKIEFTTVQKDI
                     LNLYRKDKSLEFISNLMNITPQAINNQINKIVNKIIDAYEKNYEENYYYISVCKGKYK
                     KCSRCGKIKLLSRFDKNGKKGYRSNCKNCN"
     gene            21947..22225
                     /locus_tag="KNP36_000414"
     CDS             21947..22225
                     /locus_tag="KNP36_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HBF0872311.1"
                     /translation="MKKVDFLKEVAEELGVSQIRVREILDVIEKKRNEVLQDGEELTL
                     MGVKYLTKIQKGKEGEITLKDGTKKPWKTEEKRVPKLKIAKSLKDAII"
     gene            22513..23343
                     /locus_tag="KNP36_000415"
     CDS             22513..23343
                     /locus_tag="KNP36_000415"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872312.1"
                     /translation="MNGEKLIENKELRDRNIDRVDVLEHVKEILTLANTDFSTVELVS
                     EYYEVDRDTIKKLIQRNRIELELDGLKLYKYNDIAEVLENTKKGLDVTFKIPPRGLIL
                     IPKRAILRIGMLLRDSEVAKEVRTRLLDIVHDAEEQTEIVIEEIRNEQNIKEDMLEAI
                     ISGDHNKLSVLQTELIGLKNKRISHLEDVITNSVTITESKAIINKCVRTIAVKKFNCM
                     FGKAWDEFYRFINYKLGINVRNRKGKGLARFSDEEILKMEKIAKSWLEENDIDFKLVI
                     "
     gene            23362..23435
                     /locus_tag="KNP36_000416"
     tRNA            23362..23435
                     /locus_tag="KNP36_000416"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:23396..23398,aa:Ile,seq:tat)
     gene            23444..23534
                     /locus_tag="KNP36_000417"
     tRNA            23444..23534
                     /locus_tag="KNP36_000417"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:23477..23479,aa:Ser,seq:gct)
     gene            23590..24207
                     /locus_tag="KNP36_000418"
     CDS             23590..24207
                     /locus_tag="KNP36_000418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872313.1"
                     /translation="MVKYNVHKALAEKKLLEDKIDRCINNFKIVGTKKGSDKNVYETK
                     TSVEDFNVEVSSKYQQIEDLIYNYNALDKAINISNAITNVQISNKNYTVLEAIKRKNS
                     IELDKSLLRQMVSNYDCMMSEVNRRNEEVQKNTDRMFEEKEKSKDGAELISFYKKQQE
                     WSLVDPLKVREKIEKLRDEIEEFEKEVDFALSTSNALTIIDVDLR"
     gene            24577..24765
                     /locus_tag="KNP36_000419"
     CDS             24577..24765
                     /locus_tag="KNP36_000419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872314.1"
                     /translation="MKNNKGTVLEKCEIIKQENNTYKIIEHLKDGDHEVLLSDVLDKY
                     TGDTDLNITIRLSETIVQ"
     gene            24842..26041
                     /locus_tag="KNP36_000420"
     CDS             24842..26041
                     /locus_tag="KNP36_000420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872315.1"
                     /translation="MEDILKKKEDESLVDYRIRIRLAKVNKEIDLDWGEIVELLGLEC
                     SPDHCRKVSYGLKEAFDYLNSKIQNNSTQEEIDKINEKILELKKIKVQLSDERSLVNK
                     KIREYSRIDNIIDLFNNKIDDISLHKPFLSDSSYKCYESSNQEAIMLISDIHYGLETI
                     NAFNRYNSKIFKIRIQYLKDKIIEYSKLHKVKRLHVMLLGDLISGYIHNSIRLENREN
                     IVEQIIEVSEILSEFIYELSKEIDKIIIYSVGGNHDRVLPKKDENLDKDNFTLLIDEY
                     IKLRIKNINNVIFQENIYDNDIIVAKICGNTCFGVHGDKDKMSTAIPKLTSLIKLIPD
                     YIFMAHLHNCKEDNYGESEICVNGSFSGTDSYAKNLRLSSHAMQKLMIFNESGRICTY
                     NINLSKL"
     gene            26172..27071
                     /locus_tag="KNP36_000421"
     CDS             26172..27071
                     /locus_tag="KNP36_000421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872316.1"
                     /translation="MAISKTKCLNCGEEKYTDRYFWKSHSEIFTLNKRLPVCKECFRA
                     RFLLLNGCYNGELVKALKHICFNFDVYFDEKLAKELADKKNKDELIDEYMKIINRNSK
                     YKGKTSLDNLLKEIYTGNNNDKNIVINDEIKLKWGRGFDDYEYKILERKYKEYKEYYE
                     PESLTERKLFEEICIIELEKDKSREKGDMKAFNDLSKLVSSKMQDAEIKPSQKKKAGD
                     SQDDTFGMKMMIYEKNQPVKDRLKEYEDVDGFEAYVNKHMKKPLAVALGLATGKYSIN
                     DGDKDIKFKDDVRDILEGNKNED"
     gene            27061..28809
                     /locus_tag="KNP36_000422"
     CDS             27061..28809
                     /locus_tag="KNP36_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872317.1"
                     /translation="MRTKYEKRELSSNDSSRNLLESIGEYWGAFYLANPHRFCMDYFG
                     FNLHLFQQILIYMMMKSDQFVFIASRGLGKSWLLGVFCCVIAVLKPGTCVLIAAKRKK
                     QAKLLITSKILGDLYLKSDTLKREIKSFQVNAQEVSIDFWNGSRIEAVVSNDDARGYR
                     ANVLIVDEYRMVDEGTVNDVLVPFLTNPRQPGYLQNPKYRYMQEENKEIYLSSGWYSQ
                     HWSYKKFMETVKGMLSGEDMFACSIPFTCSLEHGLLTKKRILKEMKKESMSDASFMME
                     YCGVFYNESDDAFFKSSWVNPCRVLESMFYPPSDIEYLENKKKRDKKYHLNKIKGEIR
                     IIGADIALARGVKNDNSIYTLMRMLPNEGTYKRCVVHIEAYNGMEAEKQAIRLKQLFS
                     DFQADYMILDTQGIGTTVWSYIQKANYDSDRDEWYDAYTCFNEDNTVDKSLAKKSLPV
                     VYSMKAYADENHKMAMSLRDVLTNRTLELPISDIEAKEMILEKEMIKADEIDKKAELE
                     AKYIAPYLQTTALVNELINLEYSADGGKIKIKEKSGARKDRYSSLAYTNFLADYLEEK
                     EKRKNRNNQKTVMIYW"
     gene            28826..30304
                     /locus_tag="KNP36_000423"
     CDS             28826..30304
                     /locus_tag="KNP36_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872318.1"
                     /translation="MGKKNNNKSKSKDNNSTQNQINMLNAQIGKYASVKESTTLATEM
                     YKLRSISRDKLRKALSNPYQISNTDILQDASMILKATSGTYRRVLNLISNMNTFDHIL
                     YPKDISRLKTKEKITKAYMNSASQLEKYNIKFTSAWITEKVLELGEVYLYKIEDNSGM
                     VLQQIPAKFCMITMIENNVMRYAINIKKLTDKNIISFPEEIKNIYKKYKSNLLTREEL
                     IDNTYFQLSDKAVAFNYDLDSVKGVPFFCFIFDDLMELEDMKDLKSTNAVIESIKLIH
                     QKIPFGKNDEPLVDLNLIPIYHNSTKANLPKGTAITTNPLELETHTLSDGKSKINDYV
                     KEAKEFIFDNAGINTALLNSDKINNESILNGIIADSLIPMRIQQMIENWVNFELNKDK
                     KANLFNMKFIGTTHFNKMNLSKQYREDMGYGGSKSLFIASTGFTPLQAINTLQAEKLM
                     GFDEFLIPQQTSHTQSSGRPDKSDIGTDNGNSTQAKGNGEND"
     gene            30307..30498
                     /locus_tag="KNP36_000424"
     CDS             30307..30498
                     /locus_tag="KNP36_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872319.1"
                     /translation="MSKFIYAFSEDDKKLLMEKGYRFICENKLNNKTLYVFENKSKLI
                     NNFSNEEMKRFIFTSKIRF"
     gene            30505..31938
                     /locus_tag="KNP36_000425"
     CDS             30505..31938
                     /locus_tag="KNP36_000425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872320.1"
                     /translation="MKKIKILKLPCNLKHYSDKKKLEELNSNLLPVYIYVMHEGTNPN
                     GTKFYEEAIDKAEPTLKNVPILGYVKINEDGKYDFDGHNVLTQVVQTDEGFILEEYYE
                     ERIIGVIPETNKYEKVEIDGQKYVKCKGYIYKSYSNHAYDIIMDSDEIEISMEIDIND
                     YQLDDSDGFYNIKDYVYHGITCLGSDVKGAMGSNCCLTKFSRKINYKEEISKICSEIY
                     ALEHGEGEKNLPNKNQKLNKNSEGYALAVSNLSTEIRNKLKEYKVETENWYGEKVEVQ
                     AFYYNDLIPEENIAIVEDEINWGYYYGIPYIVNEDAVILDYENKKSYIQTWREKQEGE
                     IVQVFSRQEKLKKEIIEKFTEKQKEISNLKASLEPLQAFKEEKEFELFKSKVDDVAQK
                     FELAEDEIKDIKIKAYNKEITLDEYKKELGYIFALKTLSNKQSEKENFSINDDKNNTI
                     KIPISNNNDSFSEPEEISFIKKYSDKE"
     gene            31953..32450
                     /locus_tag="KNP36_000426"
     CDS             31953..32450
                     /locus_tag="KNP36_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894820.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872321.1"
                     /translation="MKKDKAIIQTDKVKNPDVLTGKYVVPSEDTNPINLENGAVINIG
                     ELEDTEYGRDTHKIYKVTNDTLDWGIVDDPATMYDERLDERDYEVSPGQICRCRRLKK
                     GDEVTISLLHIADKSIAVKDKLQLKSDSFQFEKLPTADAKTPVAEVLELWNYEGQDSV
                     TIKVL"
     gene            32538..33548
                     /locus_tag="KNP36_000427"
     CDS             32538..33548
                     /locus_tag="KNP36_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872322.1"
                     /translation="MATAKTLKRIAHELYTDTFREYTDRDGNTITYRDAESAIKNKLK
                     EMMGGEKYNYYKFQENKWGFYNLISELISDDINRLNEEVFSPFCDFENFDLGDKKEFT
                     VENTNLFKVANIADGVNSTRRQRLLNKKVPTTAFKLSVAIYEEAERFITGRINWVVFV
                     NRVSDSYHYDIARRIAKTFEGAYSTINAKFQATGNSDKVLLELIAKVEGATGKKPIIY
                     GTPLALSNLEGVQTDLEKEEKRKYGFIQTFRGGYKVLSLPNAYDENAAEGKEWALDNK
                     AIYVIPDGEKIIKLGTEGDVLVIENTDEKERDDQQIEYFMAQKIHLGVVTAAKFGVYK
                     IQ"
     gene            33602..34234
                     /locus_tag="KNP36_000428"
     CDS             33602..34234
                     /locus_tag="KNP36_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872323.1"
                     /translation="MARAKKENISKTEVKVNTLEKDIKSTLNKKEARLNRLELQRKLK
                     QKKQEIDIEIKNISTWDVDYIDPREKQQIFSLSKVGSKDSTEFIDLDTLYRIVRRSPG
                     FFEEHRLIISDVDSLDVECTPMDIIDFLGLNSLYEYIRNPNEDYLEYFLSDKVDINSF
                     EKILNKNNVELTRRLAERAIDLHKKKKFDSGLKAKLLAKRIGMEDLYLFS"
     gene            34249..34878
                     /locus_tag="KNP36_000429"
     CDS             34249..34878
                     /locus_tag="KNP36_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872324.1"
                     /translation="MGTPLVKIYKKFLDGINDEEMLLLSNEIIEKMMYSYLEDAIVDF
                     NQCKKDLTIKYVDEKGGEIIPAAQLSYTSNYSNKNAEITLMGKDTKEEYELDKDYTIS
                     FEDEKFIISFVVETTEEIIFKYKYLGEIVSDLDLDEIKILSYGMQIHWLQPKINREEN
                     LKQMLTDSDYNAKSGANMLAKLQAREEQLRTRFNKYQQRYMLKNFEGWN"
     gene            34880..35869
                     /locus_tag="KNP36_000430"
     CDS             34880..35869
                     /locus_tag="KNP36_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872325.1"
                     /translation="MSYLSDTKKRIGLGCSTPKEKRILQLRLSFKKYLKETPTCIEVP
                     ITDIDEICITEDTKRAIVAINDITNNDKRALDEKNLLVESDLDVDVGCYLFYDNCYWL
                     TIFKEHKEMDTYKHFIIKRCNQFFNYKYKGQMYKIPIAVENLTLYSDGMADNKYTSIS
                     DTKRQLYFGSNPVTKTIDIDTRIMLTGKTVFRVTSINDFEYNGRETGADGLIKAICLQ
                     DALISKDDTINNIAWNDLSENESVIIPFSKIMGDGFINLGEENEYKIDHSQGVEWLLD
                     KQYGYCNIINQDEKKCVIQANTLAKYSGFEALLLAKDKDTNKTIDTKKITLRG"
     gene            35884..36378
                     /locus_tag="KNP36_000431"
     CDS             35884..36378
                     /locus_tag="KNP36_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872326.1"
                     /translation="MAFPNKMISNIGATLMSNQDFAKFMIYNDESQKDILSMPDIKNP
                     VKELRNKKVFLNRRVEKVLKEADISVFIIMSEYRPCFEGSRTIKKTKIEIGVVCHDEC
                     QSTANGLRDVALVCCIVDIVTQNEEIAGIGKIKLENVYQMYNLNTDYNGFVITVSAES
                     FGDM"
     gene            36378..37154
                     /locus_tag="KNP36_000432"
     CDS             36378..37154
                     /locus_tag="KNP36_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872327.1"
                     /translation="MLENYYITGLPIKLGETLGTVYQPTIEELIKFDMANLEIVNPFL
                     VLEKSYSQLCNEKIFELKCKYDAIPILDSSEEIELLSDKIKKSLSILYKTDIKNIEYM
                     NNIKIGILIKFDDKKKNAFISREDFGLVSDLILEMFCIDKKNLFKDDEDKWIENTGSE
                     REKQLIAHFKEKERKKREKEAYHLCDYINVVQNIDGYVPIDVILKMTYWQLINAYKTK
                     IQFKNYDESLGFAMSFKYQVEADKIKHWSKEIKIQTSTVK"
     gene            37194..38012
                     /locus_tag="KNP36_000433"
     CDS             37194..38012
                     /locus_tag="KNP36_000433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872328.1"
                     /translation="MMRFAIKDASNIIVKNKTTGEPLFYTADLNAFNFKLDSESVYAK
                     AKGANTIAFDGAITASLALEQEVIQMPQLAMLLASDMVEESAKVGKRKLLTSDGTKKV
                     TLENVKPVTNSISAYSVEKDGISLVKKLQFTSTVTGSNTEITISTADFNAGDKVAVFY
                     LEELPKAKVIKIKEESTAPNYVIEADVMAKTADGEYMVLYMTIPNAKAQRSIELNLTA
                     ENPSGFNMTLDVLPDENKEYVVFAFVGDEDVSPVRMASMLGAELIDEKDVKSKK"
     gene            38109..38894
                     /locus_tag="KNP36_000434"
     CDS             38109..38894
                     /locus_tag="KNP36_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872329.1"
                     /translation="MVFLDDKFLFDNISSESMNIKLVTLGDDEILNEYGLPYEEAIKS
                     DSTFNKNPCYSEDETTIEPITLQFCLCSEHGEAYEWDDYTLENICNWFWQREFKPFIS
                     YDNIEEIYYLKARKIIKRYTKDKKGVLEIEFQPYTNYAYRSFQKVITVKDTREIKLNN
                     VSNVDEEYAPVIDIECLKEGDITIRNSTISDNEEDNLVISGLELNEKITIDNLYYTVL
                     NSSGENRFNIVNRKWIRLRRGVNILKFTGNCKVSIKCKYPIIK"
     gene            38908..39357
                     /locus_tag="KNP36_000435"
     CDS             38908..39357
                     /locus_tag="KNP36_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872330.1"
                     /translation="MNKIQVDKLIQDEVRAIIPIIDENGKEEYIEVRNPDKETKEEIL
                     NKIWVGMENPDLALSQEDILKMLIDKLTNIELNIEIEDLVDGNISSELENVMYYIGQI
                     ENELTASLLMNTEIKLGQMKNEILQDRVLKETEEIEKMNNIKEKVVN"
     gene            39358..39795
                     /locus_tag="KNP36_000436"
     CDS             39358..39795
                     /locus_tag="KNP36_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872331.1"
                     /translation="MVFKSLDELVAYTKNKIAASMPEVGKEMKEIVKEEVNKQVYSDY
                     APSLYDRTYELLNAIDVSEITSDSVATEIKDSGSWFDIYSKAHAFPMERFENGGVWGH
                     GSTKYNPVFRPRTNIMEESNSKAQERVPKCFKSKMNELGVPVK"
     gene            41290..44517
                     /locus_tag="KNP36_000437"
     CDS             41290..44517
                     /locus_tag="KNP36_000437"
                     /inference="COORDINATES: protein
                     motif:HMM:NF019291.1,HMM:NF024352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Eco57I restriction-modification methylase
                     domain-containing protein"
                     /protein_id="HBF0872332.1"
                     /translation="MEKYLFNQKLLKEKYNMEIDLDLYDYKQRRLILEKWRDIIDNKS
                     IDKLNEIQLKEIFVSDILNKVLRYKSLTDNIMDYNIKPEEKTKIDGTRADIVLGYFSN
                     EESDYRVAIELKKPTTNLDAKQLRKNNHNTPVEQGFSYLPKYGRNCTWLIVSNFKEIR
                     LYNANDATEYEFFSIKDIYEKDDVFKKFLYLLSSKSLMTKHGKSRVEMLWEENIKQEE
                     AIEKGFYDLYKNTRLNLFNDILLNNKDILDVKTCLTKTQKILDRVIFVCFAEHKGLIP
                     ENIFETCIQVGKKSVSRFGVWEQVKGLFESIDLGNQEKGINQFNGGLFAEDYILNNLK
                     IPNKCFENLYKLSLYDFNSDLNENILGHIFEKSISDLEELKLEINQVNIKKKDSKRNK
                     DGIFYTPKYITKHIVNNTIRRYLDEKKKELGEDKLPELKEEDYETVVVGRNIQHKRVQ
                     VVEYKTDKIQKYINFWKNYRDVVKNIKILDPACGSGAFLNEAFSMLKKEAESVNEILR
                     DLTDGEISFFDLDANILKNNLYGVDLNEESVEITKLSLWLKTANKYSLLTSLDNNIKC
                     GNSIIDNKEVDCAKAFDWNVEFEDVMMSGGFDIIIGNPPYVSTKMIPEKHREYYWKKY
                     KDLLISEMDLYELFLYEFCENKLKQDGFLGFITPNTYFTNKSFENLRKYLLKNVCVDT
                     ILDFPYRFFPFEDVNKETAIIIINKKLPNIKNNINLISINKENMKKIKIFNSNTYNSE
                     NKITIKSIINDLDNKIVIQSNPIILKMLKCKHKLGDYLNLHKGWMSVPNKTICDGIIY
                     DKKILSSNDIKDNNQLNGILNKCLEGKDIHRYYIDKVDKFVNIENMDDKTMRWHKSPK
                     IITQRIVGQNQNKIIATVDIEGTIIFPSGNIINLIKEDNLEDIYFYIGVINSSLINYF
                     YNKFYGESNTNLTADAVKNIPIPNLKNVDKSIVINNSKILINKYGKLYLYTNKFLKNV
                     FKILSIDNNPSNKLYNFYLLDFDEFYNELSKKKKLYFKNIDELEEYFNKYKDAINRII
                     YDINVCENTINTFVYDLYGITELESKSIEDICKTTKDTVVTSLAY"
     gene            44606..45055
                     /locus_tag="KNP36_000438"
     CDS             44606..45055
                     /locus_tag="KNP36_000438"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872333.1"
                     /translation="MFKKILLILMISLLGFGVIGCSDSKEDTNEVVKKETEEKLDEES
                     TSEDIYNKKLQFLNDTKNQSEIIGDEIRLLTEKYNNYEIVKSDWKEDLISKKKIITDL
                     KSVLEEEKSNILDGVSDFQKTILQNKYNEIIEYYDYMLKGISQNLNI"
     gene            45135..46613
                     /locus_tag="KNP36_000439"
     CDS             45135..46613
                     /locus_tag="KNP36_000439"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872334.1"
                     /translation="MVEEFKIKTSIELDDKDAREKIEKLKNSGQDKPIKLNLKIGELD
                     KLSQQAEQLKGIFNKAFKIDNTALSNLKQIESTMKEINKLSRRSQESLLGGGSGNTGN
                     INNEQQDLIRQYKEISNVVSRLQNQIRTGLGDSSIERTTEQIERLKRQLDSVYAQMNS
                     SSQARMDMFDASRATRDLADMNRNLSRIEDMATQASARLNGLGDNIDTDKVNRLRNEL
                     QELKQTASRNIDLNLDVGNIVNRIQEINQEVRNLERVDSLRSNFSRIEDSIRQAFGNE
                     RVEAFRRSLEQLQGSAGNLNGDFNNIFDRLTREMRDARQEAERLNNTVSRGGGFFNDF
                     YSSVASYSIGDMLGDALTDGIRSMKDVILELDSSMTDLKKVAEPTDIDSTSELDRIRE
                     KAIQTAKDVGMSASQVQESIASSLQAGIGGMQESIAAARQSMILANVGDMDVEGASSA
                     VNTIINGFRIEPLKEMQVQVGNTTKKTTELTAAMDMLNCLAC"
     gene            47217..53291
                     /locus_tag="KNP36_000440"
     CDS             47217..53291
                     /locus_tag="KNP36_000440"
                     /inference="COORDINATES: protein motif:HMM:TIGR01760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tape measure protein"
                     /protein_id="HBF0872335.1"
                     /translation="MEDKRKRGGSVLHEYGVSLGDTVGMITATNEAIQNPEKVGNGLK
                     SVAINLAGMKVSADDGTLSLNKTAKGLKEIAGITIYKNKDTGELKNMVQLLDELKGKW
                     GELREDEQKGLAEAIAGKQQAAIFQSLMGNYETFKEIRSEFSQGLQFGSAEAENKQYL
                     DSLAGRLNELKTIWADIFQTVFNSNTTYGFLDGLISVSNGINSVIKTLERLKLTTPAL
                     IGSFMTLKTLFSGMGMTNGTRNVARLINPLNMIGTPIKATTTILQSFRHAVMAANVAG
                     ANGANVITRAGTGLGALRQSLSRTSIGIGTLNIATSLLNGAMIGLATFAITKGIQWID
                     DTIHKYEKLAEKQKEVIGTTTSEISSLQQKKKSLEGISEEYNNLASKTEKTADETERF
                     SELKQQIADIAPELVLGVDENNDPILNMSGNLDEVINKLRKAIEEKNKLLKSQEDELA
                     ITTSKTAPDTKKDLDKEKKKLDKVLEDEHNLFKNALSKSNFKEQTEALKKAYNQQETD
                     FAEHHQKLLTEYEKYNEEEEVMQKRAINRLTNSDISKTYAKQSEQKKSKMNELVANMN
                     WHDYSVGQQNSIISAFDKISESIPVEKLDQWNKKITDANINYQASGDMNQYTKELQGL
                     ANELQKLSGGSISADTWLIGLQQGFSGLDLASMKLHTFLKSYGSSLAELENKDSFAIK
                     LKNQFDALNDFSQDLEVNGKVNIKLLEDIQSGEAGQDLPQQLKDIINGFTFGEDSQIE
                     AQAQLALQVTTTLQNEGQLSNDVVKQLNDLFKGKLQLTDDILKNGLKISDKLPALPGN
                     MVQALNEQFANAFTGDNAPEITPSVNGEKAKKELKELEKFKKDTFKSDKIVTEINNKG
                     LDFAKKDLSVLKEQLDRFKNEDTKLSFTTDCADAFKDVNSLEEARKKISAPMSLKYDI
                     DVDKKGLTEAKKVYDILPDNLKKKIETEVIGIDKLDTLQNLIDKAPNKKETIFEIINK
                     NPDKLNEIDEILNNVPNDKKEAVIDFIVNNLDQLEKAKNVQEFINNLPPEIKKQLGIE
                     VEGGENAEKTVNTVQNADGTKADLLVNAEVNGESQVVECIETLDKNGNKTYTPNLNPQ
                     VNNSEKVVQCMRILDEYGNESYIPIVSPQVTNEEGLNSTKQKMDELDNKTVTPTVQIK
                     TEGETEVEQATNFIENTNPTKVIELSINNSGKDEIDNTKQKLDELNNEKATPTIEATG
                     AEQASEQLNQLSQKAQEIGQGNYHINVSTSTEQGAKNISGLIARVKQFLALKVSTLVF
                     RTETAQAAKNVSGLLAKVQSYVSRYGGKTIKTTFSALTATAAKNISGLIRKIESFKSN
                     YAGKTFTTTFVTNKVTNSSGGGGGGNSSDKTNKTERTSVTNGTPIPANLSQPRTSEPA
                     PISDETPVTKPSLFSRAVSRATSAFKVIKPKVTINNDTIDSSVKYSIELFKELENAIS
                     AVTNEIALLDKKMEHATGDEKIKYLQEQNKLFAQQKDLIKQQQDGYKAESNRLKNRLK
                     EKKMGFKFDDTGNLTNYEEKLISIEKELDKLNSKSGDKENKKDESRKKELEETKKVLE
                     EYIKVTFTELPKCEQEWEEYNNKIKEHNEELRKAQEEMWKLNKNSTWTSMYKDVEQVN
                     NEIAMIDVLLKNATGDEQIELLEKKKELMAKKAKELSETTAYLQETQKELQQKLQGYG
                     FTFRDNGDITNFIQHKNQLKKNMTDEEFKRMEDAAEGYLDLLINKIPDANKEIAESKK
                     EIEALNKEIQDAYKDQLKEAQSLQEKIRDMYKKELEERLKEIDKETKAKIDSLKKQQD
                     AYNDSRKEAKYKDDYEEQQDVISDLEKQIAIAERDSSLSGQKKLKDLQKQLKEEQKKL
                     QDLVQDHVDDQVNDMYDKESDRLQEEADKLKEELEKKYSDENLVDLINEAISSGKFVG
                     LDGEVEKLQDAIIEYINKYEDGMLAMGSVTKQEWLDTLKEGKETLEDINDILDELDLS
                     KFAMPNYNPPSNSRSRSAFPTSSVNFNSPFFVVQGNVTKDTMKDLEKFGRDLENRVYR
                     KIVENIKS"
     gene            54441..54596
                     /locus_tag="KNP36_000441"
     CDS             54441..54596
                     /locus_tag="KNP36_000441"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872336.1"
                     /translation="MINNIEDCKLLIEAEIRMKDIDEKELISQRDILKDLNINEKDLE
                     DIEVNFE"
     gene            54949..56664
                     /locus_tag="KNP36_000442"
     CDS             54949..56664
                     /locus_tag="KNP36_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872337.1"
                     /translation="MHFNVNLKQIKSDYTLTIHKMNKSFLGQIPINFLNSIKRELGGV
                     DEIQLTIPKYITDRFLFNKIINPIFEEVKEERLICLNNKEYFVVKNVVTTDDKLKVVT
                     AKSKEVKLGKIDVNIEDYGLQMFTKDEEASIISLNDYLKQETGWKLGYVDDSIAYETD
                     SEGNKREKVRWQESINSNWLDYFNNELKEQFECIADFDTYNNLVNLYHIDSFGDNIQL
                     YLSHDNYIKSLERTTNSDDIVTRLKLEGSEDMDIIGATVTGYDYIENYSYFLDNKEMS
                     EELSRAIKKYQEMNEIREPIWRELIDTKLKKQRERDSKSNEWLHVIETIKAKKDIKKT
                     YDNPEHKDEVNSAKLAVEISELEDKKVILDVQIKHLEEEIAKLDESIKDINILCKRET
                     STDEDGYLIFNEALLDELNEFLYYDTYTNDAFLKVEDLIAEGKRQLSLKCIPTKEWTL
                     DVINFLDRIIDINFRQHWKGDLSLGDIIVLHSKESKEEELVYFTSFTQNFKNGKLDTL
                     ELTLSNKKVKEDDKRTIADYLTKAEHATRTLNSKRHLFIQQQKKRINLPDEYIPKKNI
                     QKELM"
     gene            56666..58588
                     /locus_tag="KNP36_000443"
     CDS             56666..58588
                     /locus_tag="KNP36_000443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tail fiber domain-containing protein"
                     /protein_id="HBF0872338.1"
                     /translation="MILDNSPADSWIRITGVIVTYNNTLYQVVDTETNKKYIYWDADN
                     PGTLKVSNVRLPEGNTQFLVVVNDNGKHTEVPINSSIFDISFDGNSRKNTEEQIWGLY
                     ETDEKHNEKFVVIEKDIDGIHQTVLEVQEDASHIKENMSLIDQRAENVNILVKEVTKN
                     FGGSQENITLRENINKAIIKLNADLGTFSSNMSNYFNDNEVTDEEKEKIDIELNLLDT
                     DKASLYTELQKLIDRTTGVDLVAINTSKTALDAASTNLNSIINSVISDSIITPSDRIL
                     AINANAQYNLKINELKNTVDKIYITGMGGSISEEFSQINATAKEIKLEVAKVDGATKT
                     NAAEIKLTKDDITMMVTRNNSGSIVGIKPDKIEFGFNDISNYVEISRSGLTVNQGAIA
                     CDILTTPSGHEPIIRLFGSSRSGFAIDARQSDGSSQASAIRLKYDSNNYFWVGYDTAE
                     IYVDGEEHFIVERDDTFVRCGGATFTFTNGDSLGVGYSFYPERSVTDLGCERYKWRYL
                     YARSTLSESDKKFKENIVYIKDIKNRTRSSITPTPFLDFIRDDFKPATFDYIAEKDRT
                     IADSQIGFIANDFKDSYVGKTFLYDYGEENGLMFSPSGYTTVVATALQEEIQKREELE
                     MIINELNEKINNLGGY"
     gene            58590..58745
                     /locus_tag="KNP36_000444"
     CDS             58590..58745
                     /locus_tag="KNP36_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872339.1"
                     /translation="MEVNLQKAYTVAFEEIKSLYNELILYKALNMQQQEEIENLKKEL
                     EEQNKEQ"
     gene            58757..60835
                     /locus_tag="KNP36_000445"
     CDS             58757..60835
                     /locus_tag="KNP36_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBF0872340.1"
                     /translation="MKNYEIKNHTIEVDFSNYRINKRLLDYFIYNENDVKTAYIEAIL
                     KNKDEIIDLSEYDRVLVSITKSDGQKVNGECEVVDAENGIVEIELSRQALASVGINTF
                     QLSLVKDGTLLNTTNLYYRVEEGMINDDDITSTDEYGVLLVIIAQAEEIIKNNKELTK
                     RVEQLEITILGNEEVRDKAEQIRIYNEDIRNIQEEEREFNELTRQNQEANREESIQNM
                     QIQVDDKLTDCQLQLDEMIDAKSKEIDNIVDDKMLDVQVQTDKKFQDLDTRANNTFDL
                     YDKTFEDKLTDNQEQIDYKLDEVNQAISNVEDCIDESTTKLDTKIKEVDDKIVEVNTA
                     KTDMTTTVSNKITEFENRFEELESLDARGELIQARESVDGTVKDTLKDRLTYDFEKVN
                     EKIAEMTSAATNVAFSKSYVESDWVADGEYFKLIVNHNLVTENIFVAILDEATKKSMT
                     NSYTTVDSNTIEIFNESNIDVKVTVVNGNTNKEVIQATINDNITTLDSTYSSIKIDAK
                     FDESLTKINENKSNIATNLEKINLIQSKVGSSELSTVSKNISDAVNELDASVKVLESG
                     GNTNEQLKILKENYNKMSVEILKILFELELDKEATADEAGYWYDTLYDSKNISNLDGL
                     KLNKFKQQLELLSNSGTVLFKNVTVPFLCNKIRYIHDLGSNYSETKTEESYQKGDTEI
                     KINKYSYEVR"
     gene            60846..66125
                     /locus_tag="KNP36_000446"
     CDS             60846..66125
                     /locus_tag="KNP36_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872341.1"
                     /translation="MKKNKLLQRGSLFGNKEFKIEEFNKNFDTFNVKDIFTDMDSGSV
                     FIIKDDLKLYAAGYNVFGNLGLGNKVSPIRYFSKIDIDNVKYVSSSGTHSLLLKNNGD
                     VYSTGLNTDGELGLGDNIDRNTFTKINISNVKQIACGNGYSMLVTNDNELYVCGNNKF
                     GGIGLGNTSTVNTFTKIDNLSVKEIFAGVSCSYILTLNNELFSTGLNNYGQLGLNDTT
                     NRNIFTKVNLDNVIKISTAQGAVNFLLENGDVYGCGDNSSGQVGVGGGATVTVLTKLS
                     ISNVKNIESGRYHKFYIANNNDIYVTGANPDGRLGDKINCDRSTYTPRKSSISIKNIS
                     KIKCAHAISFILTSNNELYMTGDNNYSFSYLKRYDKFIYGFEKFEDFDIEECNHIESI
                     DNRLLINKNDERVLDIGLENNFVNISLVKANDTSTFIVVNGNELYAAGYNAYGGLGLG
                     HNRHCYEFTRVPLELEEGVTIKDIYLNLGSYFTFILLSDNTLYSTGYNVFGVLGLGDN
                     INRNTFTKVNISSVDKISVGDNHALLKTTTNELFSTGLNNYGQLGLNDNTNRNIFTKV
                     STVTYVNEIIAYSNSSYCIDNSRISYAAGYNVFGELSLNDTSSRSVFVKMKYLRYKTD
                     TTVSDVSNIAEIIPFNNGCLIRTTSNNYYVSGRHNYYSTSIKNSVTDDYYSRFGEFVG
                     SKNSNANEVAVLIDEPKLSKVLVSNYNLCLLLDASDGGYKEIKFTGRPSTFGASSQDK
                     NLGLRSLISSSMPYYNHYLGTDNLLYTTSKTRMESKFEIRGRNAGGQRGDSSYYSNSQ
                     KYTLSNAFFAYNSQVIYASRLRIVIKDYFGNIYCSGVNSHGCFGIKKPYDVRHDGFVN
                     ISKQFSKKYIISNIKEIKSDRQALYILLNNSEGYVCGNNAGNKLGTIKARSEFIKVPI
                     DNIKEFIPSNDCLFILTNNNQVYSIGTNDLGQLGLGDNIDRGTFTKVPIDNVKKVITC
                     YKSSYILTYDNELFSTGSNGYGQLGLGDNINRNTFTKVNISGTIKDIFCGRYVFIILL
                     ENDNIISLMGCGNRNYISSNTNSNSLTKINIEGLTDPSTISNLMLEEGKTIITMKNRI
                     FVTGYNSLGGLGVGTSYNNSSGYIEGYKDLAFNSNIKEVALGEYTIFVLLENGDLYSG
                     GNADDGIGFNESGTVVLKKLTSNIKHIYANGKNAYYIDNDNALYVFGSRQLGQINNYS
                     DVVQKTPVRNCLNVKQVYTQHNGLIVQYTNNKLEGKGNAVVGQVGIFNGHEENQIANT
                     SGDNPSDLSFSNEMSIIRNNYGLLVNKKIFLHNDDSINYRIPFGTNAGNYSTSLPFDN
                     IKKMSLSSTHSILILENGDVYGCGSNQFGELAINKSELTTTSEFIKINLTNIIDIACG
                     DNFTYFLKNDGSLFSIGKNSEYQLGIGHNDEVNELQEVLTISNIREIYAYSNYILAIT
                     TEGQLYVQGYNINGILGLNENTKNTIIKLFTKVLENVKYIKSYDDKHIFVIKNDKTLY
                     VTGINKETYKIKDVEIGSMLYTFSQIYIPRDVNDIVDALIKDETLYIISKVDSEKTCL
                     EIKNKSYSSIEIDLQNPNNELTKIEMFINNISSSIIEDLSTGTVTFEINPENLVLGEN
                     KIVFKAHSDIGNNLYINVYIYKKETGATIVKDSTVLIDGNTYNVSSIVDNSQDVVLTL
                     NKGLLEDLNSNNPIYHLVNKLKVQLKINESDTFKDMVKVETRKTENGYKEIYELKDMN
                     IQSAQPKVIVEEGNTNTTIKKPSMLFNLDVETL"
     gene            66137..66460
                     /locus_tag="KNP36_000447"
     CDS             66137..66460
                     /locus_tag="KNP36_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872342.1"
                     /translation="MIKIDKEKIEKSRQRKELDDLDSSQKTQDNDITDLMLATAEICE
                     MVLSSQQTSTMSLKNIKLNEGGSSMAAIYVGLIERGLKTIDQVPVKYREEVRKMCEAL
                     EISLS"
     gene            66540..67079
                     /locus_tag="KNP36_000448"
     CDS             66540..67079
                     /locus_tag="KNP36_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872343.1"
                     /translation="MLNEDVVKKLKNVPNNTNTEIEKVNTNIETAKTELNTKIDQLIA
                     GGSNVASTQTITIDDWVDDTENGFKATVTHGLLTQRIVVNIIDATTKENVVTNFKIID
                     DNSIEIRSETRSELNVYVINGNAETHFINATVDDNRVSEMTTYSSKKIEDRFVNLEEK
                     VNGGLSNIATSVNELITYC"
     gene            67096..>67305
                     /locus_tag="KNP36_000449"
     CDS             67096..>67305
                     /locus_tag="KNP36_000449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872344.1"
                     /translation="MQTEWNFGYNGSPQSVILKPGKYKFECWGSSGGINNSSWHTDAK
                     GGYSKGEITLKKQTTLYVYVGESGFA"
BASE COUNT        26832 a         7538 c        10394 g        22541 t
ORIGIN      
        1 tattattgga aaattaaatt agtaatatgt ataaaaaact ttctattgtg tatataattt
       61 cattaaaata ggcataaaaa aatagagcta atagagattt cacgctcttt atagctctat
      121 ttaagtattt tataatttga atacaaacac taataggagt agccaaaatc attttttttg
      181 aactactcca tatattaaat tgctattgct aaacttccat ttttatttat gctctgaaca
      241 atcaatgttc ttataaatgc accaggatta cgtatttcat tataatttat atcttcttca
      301 tcaactgtat atttattaaa catataatct aatgctgcta aaactctagt aactccatac
      361 tgcaccgaca atccaactaa gtcatttata ataatatctt tttccatgtc taatttactt
      421 cttaaatctt cttcaaataa attatatcta tctaaattta tctgagataa cactttacta
      481 taattagaac tcaaagagca accagtatta tcaaagaatt tcgatatttg tattctaatt
      541 ggttctgtat atttctctga gatagtttct ttcgtctcgt aacgctttgt atctattgtg
      601 tcattactta catcaaataa agttttagaa cttcttaaaa aggcttctgt acgcttgttt
      661 gatttcttta tgtattctgg aagtatagaa ataagattgt cttttttaaa tcgtattctt
      721 ttacctaact tacttccttt agcatcagcc caaattaatt ttttaatttc aagttttaac
      781 tcatttacat tttcaaaact taataagtga tttaaagtat ctaatgacat agttaagtaa
      841 ccttttccac catcttcttt tttaagatgg tttttgtact cttcatctat gactatatca
      901 aatttacctc tttttatttc tgtagaataa actaatccaa ctcgtagtaa tacattatgg
      961 ttatgtctgg ctgtaacaat ggaaacattg catatatcgg ctatattttg gaaggatact
     1021 gcttttctaa cataattttt attagatact ataaaatgat atgctaaata ctgttttata
     1081 gcacttttac ttaaagccat acatttactt tcattagtta caatttctat tgtacctagt
     1141 tctgtttcct tttctgtaac ataagaaaac tctgatatag tttttaattt aggacaattt
     1201 gaacaaaatt catttaattt atgactatca aaagaaggat tattttttat tgcacaagaa
     1261 ttacaagcag aataatctat tttttctact tttcttatag aagttttaaa aacatctaat
     1321 atatctttta gttttgactt tgatattcta gcaactggtt ttaattcttg cattttataa
     1381 tcctcctttc tctatatatg attattataa tcttaatgag gtataaagta aataaatacc
     1441 tctgtatatt aataaatatt attttttata tcctgtatag tcctagtgct acagttccat
     1501 tttgttgcac actttcttaa acttatgcca ttatctaaat ctttttttat atttttaata
     1561 tcttctaggt taaatctttt aggttttttg ccttgtgtaa ccacataata ctgcttgtcc
     1621 tttaggtcaa tatattttat attagagtta tctaattcat ttatattctt tttttctaca
     1681 agtacaaatt ctttatcttt atatttaaga ctcataattt tctcctttga aaaatcaata
     1741 atttcagaag tacggagctg atatagccat tttggtgatg attcctttta ctcaaattta
     1801 tcttacccaa aaaataaatt tatgtctata tttgttaagt acggagctga tacggtcatt
     1861 tagctcaaat agagtggttt caacgtcttc tgttaagtac ggagctgata cggtcattta
     1921 gctcagacat agtgatttca gaagacgtga gatttgaaat tactaagaaa agtaaaaaat
     1981 atgttacaaa aaaaattttt cgacaaggaa ataattaaaa aaaggtctat tttttgttaa
     2041 gtacggaaga tatacggtca tttagttttt ttgaaaaatc tattttttgt taagtacgga
     2101 gaatatacgg tcattttact ttttttatta agtttattta aaataaattc gacatttttt
     2161 gttaagtacg gagaatatat ggccattttt aagatttatt ttctatcatg tagtcaggta
     2221 aagaaagtat agtattattt ataagacgtt ttcttttttc aaaatcttca tagaaataaa
     2281 catcaaaata agaatttcct cttttatagt ctttaattat aaattgattt tcttttatct
     2341 cattaaaacc tagttctaaa tactccatat tttgctttac tgttttactt ttattaagat
     2401 gaacatcaaa ttttaaatct tctatgtcat atctaaaact tttatttttt atatcctcac
     2461 cacaagatat aagaaaagac cttctaccct ctaagaaata agctagatta attgactgtg
     2521 ttaattgtaa tttttcaagt tcatttctat acattatatc tgtattaact ctttcgactt
     2581 cttcaataaa agattttgtg attttaacca actctctatt attattgttt tcatcattta
     2641 ctattgttgt actagaaaac aaattaaaac taatctcata ctttaattcg cctttatcat
     2701 tagtttgatt cgaataaaaa gtataataag gtaattttaa gagtctattt ttgatattaa
     2761 tatagttctt ttttccatct gaaagtccta agtactttac taaatcgcct aaataaaatg
     2821 aaaaagagtt catgtggcta taagtataaa caaatctaat aatttcaagg tcttgtttat
     2881 ctaaatatat ttttggcaaa gccctttttt ctgtatcagg atttattagc tctagtttaa
     2941 gattttcaat attttcatct tgcccaattg aaaacttata gaaaaaattc atttgtttac
     3001 ctgaaagatt cttagcacta tagtcgtctg acatgtattc attttcattt tttttaacat
     3061 tcaagtgcga gtatctttta ccttttgtga aaggtaaaaa aattccaggt gaaatatgtg
     3121 gtggagtttt gattgcaatt ttattaatat caaaatcata atcatctttt agtacttctg
     3181 ttatacacat tagtatatca tgtataaatg cggaatttat tttgctagta cttaactctt
     3241 gtaaatatgg gtaatcacat atgttataac tagagcttga cttccactca tctaaaaaat
     3301 cttttctttg ctcctttaat tcttttggat tttttactcc agcactaatg attcttccat
     3361 tttttaaata ttcactttca acaatttcta attctttttt taggtattta ctgctttttt
     3421 ttcttgaaga tttagtatct tcacttagag aatctaaagt catatcagac catctcttct
     3481 taagttttaa tgatgatgag ttctcttgat ttcttaattt tttaacatca tttactgtat
     3541 ttatcttttt aaacttatct gaaataagag aatatagaaa ttcttcaaat tttaaactta
     3601 tttcttcagc agacataccc tttaatctaa aaatttcaaa atattttctt gttatcattt
     3661 taaatctatc attgtcatat ataatatgat agattaaatt tattttattt aaatcttttt
     3721 gttcattact tatgttttct ttaacatctt tactcataag gttactcctt aatatatttt
     3781 tgcttataaa tagatagaac ttcttgtatt ttgaagttta aattgttatc ctccttaaac
     3841 tctttcaagc ttttgttagt ccaatatcca gattgagtat attttttttc atttagatgc
     3901 atttgatgca taataccaga aatttttaaa ttggtgaaat tcaactgtac tttattatct
     3961 aaataatcat taataataag taatcttttg cgaattgttg agtatcccat ctcttttaat
     4021 ccatttccat atctagcatc tggtttagtt ttaattaaat attcagaatt agaattaaat
     4081 agataaaatt cagcagcatt gctgtcttgc tccaaatatt gtttatactc tttttgttct
     4141 aatgtatctt ttgtaaaatc aaataagaac ttgtccagct taaattctgt atcctttaac
     4201 tttattaatc ttttttctaa atctatgtct tttattttta taccccttag gtcttcagca
     4261 tctttaccaa taagaccaca aaaagctgca taaattataa acttatcttg tgcattagtt
     4321 agcttactac atacctgaag tacttcatct tgtgttagat attttgataa atcaaattca
     4381 gcgactaaat tttttggttt agaaaagtga atatcgtaat ttaaagtttt aaatatctta
     4441 ttaattttaa aaattatagc cattatggca ttgtatgttt tattctggct catatctctc
     4501 acaatttctt ctttatcatt acctactatc tcaacaatat agtcattttc ttcctcaaca
     4561 agctttcctt ctttagcaaa ccaaaatatt aacactttat aaactttgag tataccaatc
     4621 cttgtttttt catcctcatt ttgtaatagc tctgataata cattttcatt ttttaaatta
     4681 taattcataa attcaaacat ccttttttta attatatata tattataaca tttaccttct
     4741 ccgttttaaa tagaaaataa aaaaaataac ctcaaaataa tgaggttatt taaattaaaa
     4801 ctacgatttt attgtcattt ttatttatca tacttcttta tgtattctaa taaagccata
     4861 ctcattaaat cagacttatt aaactctctg aattttccac aaaactcatc aaataaattc
     4921 catgcatctt tattcaacct aactgtagtc cttatagcat cttttgaatg taaatcaatc
     4981 ttaataccat cctgtacaac ttctattaca tttgtatctt ctttattctc aaaccaattt
     5041 aatacatctt gtattttatc atagtctttt gctaaagaga ctatattatt tttaaattgg
     5101 ttgtcaatta ctatgttgtg attgttgtca tcttctattg tcatattaaa tgtattatca
     5161 ttattactct gttgtctatt gtttactact tttgtcatac tattgtcacc aataaacaca
     5221 tactcatcat ttatacgttt ataacctctt ttagtaaggt attttcttat gctactttca
     5281 gacacaccaa gccctatagc aactttagtc aaactcttac tattatttaa cttattatta
     5341 atatattcaa ctatatatgt tatatcattg ttttttaaat cattccaagt catatactca
     5401 cctctaaatt aagtatacta catgagatta ttgttgtcat accatattaa ccagttgact
     5461 aatagttttt atttacatat atttctaaag tgcaacaaac tttgatataa tttatttata
     5521 aataacagat taatttaaac aaaatttata ttaaataaga ttttaaatta tttattaagg
     5581 agaaatatat gcttaaaaca ttgtttattc tattagcagt ttttgtaatt ataaaactat
     5641 ctattttgat atttaaagat gcattaaaat ttttaaatat gtttgaaagt aagaatgaaa
     5701 gctttattgg gtggttattc ttatgtatat tggctttagt tatttataat ttaatagata
     5761 taatattata gataaatata tgagttttta tatttaaata caaaaattat tgcatttaaa
     5821 tatatagtat cctttatttt tttatatttt tgctttaata aatttagata cacttgtaga
     5881 atgctatatt ttggaattaa actacaagtg taattaccag ttttttataa aatatgttat
     5941 aattatttaa aaaggagact ataattatgg ttataaaagt aaattttggt ggcaactata
     6001 gtcctgatta tatatatgtt cctaatgaaa ttagtttaaa aaaatatgaa attagaaacg
     6061 aatttcatat ttggattgac aatacagaag atgagcatcc tttttggtgt tatgaaaatg
     6121 gagtccaaat tggactccat tataggggtg atgcgatagt ttattggtta aataactaca
     6181 ttttaaagaa tgctaatgat aaagcaaggt taattgaaag tttttcaaat aaaaagttag
     6241 attatgattt aattataaat ttgtaaaaag agtattttaa tatgtggaat attcctttaa
     6301 gtttaaagta ttctaaagta gctatatatt cttacataac gtagtgtaaa cttaggctat
     6361 tcaactagct tttacaagct actacccttt agggtagtgg cagttgacaa taaacacctt
     6421 tagaacttcc aatacctgca aaagtattta aatcttccgt tctgtaaagc atagttttca
     6481 cttccattca tttgtttaat tattaggtta aaaactccat aaatctttat ttttttcttt
     6541 gtagtcatct aaactttcaa aatattgctc taaaggttta taatattcat tatgacaacc
     6601 ttttaaagcc tgtctataat catctacagt atcactcgat attataatca atttcaaatt
     6661 attctcaagt atttgtttaa gtaatataaa tcttcctatt cttccattgc catcttgaaa
     6721 aggatgaatg atttcaaatc tataatgaaa ttctgctaag tcttttaatg taatatcttt
     6781 taaattatta taccactcaa taagttctaa catctttggt tctacttcaa atggttgggc
     6841 taatacacta ttagttccta ttattctatt tggtattttt ttgtatatac cagatagccc
     6901 catattatga atatttgaat tatacataag ttgtccatgt aaatccttta tgtacttttc
     6961 agttaagtat tcgcccaatg tatctattac agtttcaaat acatagcttg aatttactgt
     7021 tgttataaca tcatctaaag tatggtcacc ttttacaatg ttgtgctcaa ttaaatcttg
     7081 taaactttca cttgtgaatg tacttccttc tattttattt gaatgaaata aaaaattatg
     7141 tcttaagtct ttgtataaag agtttggtat gtttttggta tattttaatt tttctataaa
     7201 cttattttca atcaatatat tcatctccat ttttaaattt attttatatt actaatatta
     7261 acaaaatgta ttatctttta cactatcttt tgaactttat ttattaggaa tgataattaa
     7321 ttgagaaaag aatgttatca taattctctt ctcaattaat tagttacatt gtaaaacctt
     7381 ttaatttacc atctttaata atgaatgaca accccattgt atgccatcta aaagcatcat
     7441 ataggcttat agtatgtata tctttgacat aacatatcat aataatctcc aatcattatt
     7501 cttatatatt ttcaactttt tgaaacatgt atatttcatt gcttaaatca taattaggct
     7561 cccagttttc tatgaattta attgcattgt catagttctt tttagcagtg ttcttatagc
     7621 tattaacacc aaattttttt ctataatctt tccatagtga aaagtatact ctttttctta
     7681 atttagcatc ttcataagct gaaaaattta aacattgata tacttgtatt accattctat
     7741 ttaccaaact tctaatagtt tcttgttgat tgtagtctat agtagaaaaa tcatatagga
     7801 cattaacttt ttcctctaat tcatgttgac cagattcaag ttctgcttgt ctttgttcta
     7861 gtttgattat aacttttaac tctggagata agttttcaaa agggtcattt aacttttttc
     7921 tcatactaaa atattcatcc attattttat cgtgtatttc ccaagctaaa tcagtatcca
     7981 ttatcttaat taattttgaa tatcctcttt cagataataa aaatatatta tcagcttttg
     8041 atatttgcat tttactatat ccaagtgttt gtaatagctc taaattgtca tccgtgtcac
     8101 ggataacttt taaatctata taatctatgt cttctttaaa tctttttata ttatccttta
     8161 ttctctctct tatcttaaaa ttaggctgat tatgtatttc tgatatagtc ttatccgtca
     8221 tacatttttt atcttcacca aaaccacctt ctataactgg tatttctaaa ttcataaatt
     8281 tttgttttcc tttaactttt aatttattca ctttttccat ctcccttttt aaattattaa
     8341 atgtagttat tatgagtttt aaaatagtaa ctacattttt atgttaaatt acaatttaat
     8401 taaaaattga cataataact ttgtatttac taaatgaatc tctttgacat tcagtagaca
     8461 ttgttatgtc tagtaatgtt ctcacttctt gtcattattt atcatattct tcaaaatatc
     8521 taaattatca tatatatatc taataccatt taaaaattga gtttgttgtt ttatatatct
     8581 tcttatatct ctactctttg gatatttgac caataagtcc ttaaattttt caatcatttc
     8641 atttcttgca tcaatatcat tttctatgta ttccaattga tttaatatag ataacttatc
     8701 attattattc atttgtgcca cctccagttg acaaggaata ataatattct atataagtat
     8761 taatacaatt agttaaataa attttactat ccaatgttaa gtaccagtca cccatacaag
     8821 aaggataaaa gtaatattta ttatcctgtt ttatataaac aattgaactt ccatcattta
     8881 aaaatacttt aatgtttcca ttgtcattta acttattaac cacgtatata ttacttaaat
     8941 gatttatatt acttgatagc tctttgtaag ttgcaactgc gctatctaaa tcttttttat
     9001 ttttaaagct atagttccag tctcccatac aaattggata gaaattataa acttgctctt
     9061 tagtatcata taaaactata ctttcatctt ctaaaacttc aataactcta tctgtggact
     9121 ctatataaaa attatctaat tcagcagcct taacttttgt tactcctgaa actcctacaa
     9181 tgattaaacc taataacatt cccataacta tatttttgaa tttcattttt atatcctcct
     9241 agtttataat tatgaccccg tacaagcctc tataagctgt ttgaaaatca tcttaatgta
     9301 tttttacaat ctttaaaacc tttttatcaa atcactatca ttatcattta aattataata
     9361 atatagctat aatgatagtg atttgataac tcatatatca tattaaaaat ataattttaa
     9421 actcttttat tacttcatgt cctatattaa agatatgaca ctcttttata taaaatataa
     9481 tcctcatcta tataaaattc attgtcatta attcatcgcc tacatacatt tattgcatac
     9541 ttttatatag ttcttttaaa tcttcatttt catctaatat tacttttaaa ggtttcatag
     9601 tataacaact tttatattta tatttgtttt tattgtaatt ttcatcaaat ttactcatat
     9661 attccttata cttgataaac aaactgttca atatatctat atctatcaat ccagacttac
     9721 taagtttatt cattctcata caactatcta tcatacgagc caaagaccaa gccacttctg
     9781 caattgcatc ttctaacatt tgttcattag atttataagc ataagaacct tctttgtatt
     9841 tagtattatt cttcactatt ttattaagat ttgtctctat atctaaaccc ttactgtagt
     9901 actccatgca tttgtaatgt ttttttatct ctctcgacaa tgctttgtaa aatgtaacat
     9961 tcaatttcat tattttttct acacatgtta atccaacatg aaaaacttct cctgtaacat
    10021 tattttttat tgtagctata ttttttatag ttcttccaca gtggtcacaa gttccttcgc
    10081 cttttgtata acttatcaaa atatactcat tcatgcttaa acctccagtt atattaaaat
    10141 cattcttttg attacatttc cataaagata aaatcaagta tcaaaattaa actatctata
    10201 tacttttcta tttctttata tttcaagtca aatatatctg tattatcaat tttgtaacat
    10261 aatttatcta tttgatattc tgtaatttca tctattttat tcttatattt atatcctgat
    10321 agtgcttttc ttaaatcttt tatgtatcct tttagttctc ttaagctgct tgtttcaagt
    10381 gatgttttaa taccttttat ctgatttgct aacattttaa aaccctccaa ttacattctt
    10441 ttaagcataa cttttaataa ttttttcgta taacacatac tcattatcta tataaaattc
    10501 attatcattg agataggctt caacataaaa ttcaataaaa ttttctaata aatattcttt
    10561 gtccaatggc tctgtcatct tattaaattc ttcaattact ttttcttcaa gttttttgac
    10621 catattatta attttatttt ccaacatatt aaatctttta ttttcaaaat ccatacaatg
    10681 taatttatca attaatgaaa tcgcatactc gagaggtctc tgttcttctt ctgataaaaa
    10741 agaaaatttt tcacatacag atttaagttc taataaaaat ttatgattat cctctatttt
    10801 tatataatta tcattgtaaa atccaataga ccaatcatct aatgatttat taagatggca
    10861 taatatttca tctatccaat acatgtcatt gtcttcgcaa gctttcctta catcctccct
    10921 tagttgacta tttttctccc atattatttt taattcctct ttattcaaat tagctatttt
    10981 tttcattttt atacctcccc taatatgttt gttttatcaa attactatca ttatcaatta
    11041 atatataact ttatatcgac aatgatagta acttatgtaa tctattaaat ttaatatttt
    11101 gtttcctttt tgaatttgca gactattgta tattttcaac aacttgttta acttcaatgt
    11161 catttatatt acaattattt tcatatgcta aaagttctaa tgtggactgt ttctcccctt
    11221 gaaatgtacc atacagacta tatgaaagta gtaacttacc atgtaatcta aattctaact
    11281 ttgcagttaa agctatatat atatcttcat atgatagttt ttcatttaca gaaccagcaa
    11341 agataaattt tccttctttt attacttcgc accatgttcc atctttatat attgaatatc
    11401 catttattat ttttttcatt ttattacctc caattatatt aaaagttgaa ttttatttac
    11461 ttatactttt tttaatttta gcaatatagt ttaaatactt tttactatat tcttgtatct
    11521 ttgtattttc tttagctctt ttataaattg tctcttcatc aatatttgtt tgatactttc
    11581 ccttacctct tccaaaatca aaaggatatg taagccccat actgcataat tcttgcatta
    11641 ctaaatttgc atatttccat acagttggtt tataatattt ttgttctcaa aaacctattc
    11701 ctattaagtg ttctatagta ttgttaagct ctatatttaa attgttttca attgttttat
    11761 tcatattttc cctcctgtta ttttaagtta cttatatttt ctgaatatct tgttaaaaat
    11821 ttttctatat cattaaaaac atatcttaaa aaaggtattt tatattcaca atctatattt
    11881 actaacttat ctttttttat attaaatgta aacttatgct tatattcctt gttattatat
    11941 ttaaaacata tatccccaat taaattattg tcacaatcct tcattatctc attaaattta
    12001 aatactttag aatagttatt agccaataat atttttttgc attgctctgc ccatgttttg
    12061 acatatgtat aattatttat tgttaaaata ttatattgag aagagtcaat tttattttgt
    12121 cttaataata aaactgtttc catccattta catcctttac ccatacaaaa caattctttt
    12181 acacattcct tattatcagt gtcctcttct tcgctttcaa ttaatttatt gtaatctaat
    12241 cttaaatcaa ataaggtatt atatatcgct acgtctgata tagtccaaac cttccaactt
    12301 acactactat atattttttc atcttttaaa tcaatttcac ctatattatt tttaatataa
    12361 tcctctacca attcaaatat tatattttgt ctagtatatt tttttacatt tcttacaaga
    12421 acttgaaaac ctggatgccc ttctatatca taaaatacga ttattttatt cattttattt
    12481 tcctcctata aattaattat tttttactta aaattcttta tattgaattt tattttcatt
    12541 atctaaatac atcatattat taatattttg tattaattgc tgtctcaatt cttctccttt
    12601 taaagcccaa tctaatccga ttaaatttcc tagtctagta cttaaagaat tataagttcc
    12661 tgcttctcct attatttcac cttctaaaag gtcacatata tttattaaat ctgtgtcata
    12721 tattcagaat aattgaccat gttattacct ccttataatt tattagcttg ttccaataat
    12781 tctaattgat tgctgtttcc acattttaaa ataatacttt ctgtagtact ccaatagcta
    12841 ctatctaaat cctttttaaa caatgatttt atcttaatta ttaatttttt catgatttat
    12901 tcccctttca atttttttat tggaagtggc gtttttaaag aacgccctaa aactttttat
    12961 ttaagaaact atagctaaat aatttgatgc tatacaaata ttctcataac gtaagtcagt
    13021 tccatatagc tcataattaa agtatctttc aagtgtttct tgacctaact cttcaatatc
    13081 tcctaatcgt tcaatataat tctctgcaaa ttcaatatct gtcatatttt cataatattc
    13141 tatatcttct tcgtataaat tttcaataat catatctcta tcaaaacgta aatctcttga
    13201 aaatgcttct atgtcaaagt agtaagcaat attttctata caagataaat caccacaaca
    13261 tatttcttct atgtaactac gtcctaaatt ttcatcatcc aatggtgacc tgtcatcaag
    13321 ttgtataaaa gtataattac ctgataatct gcaaatatcc ccttcaagca tgtcataaaa
    13381 atcaatgtat ccacatccaa gtaaagcctt taattgttca atctcatatt cttctaactc
    13441 ttcaagctct tttgctaatt catttagttg ctctatattg ctatgttcac ttatttctaa
    13501 cccttctata tctgtttcaa aatctgttat gaaatactcc tcatattctt catttatccc
    13561 tattctatct aatatttctt ctaattcttc ctcgtttact ggaaattcag cccattcccc
    13621 tattagttca ccttcgttat attttcctag gttagttatg tatatattta gcattttata
    13681 tcctcccttt ttactgactc gttactagtc attttgtaaa aaattttatt ttatgattta
    13741 attataatcg actcgtcacg agttgtcaag tatttttttg agtagatttt ttatctactc
    13801 atctattttt tctattacta ttttattacc atcaaaagtc aacaaaactt ccctgtctag
    13861 tttagttatg tccatatgtt ttatccatgt agttggaatt gtaaccctat tcgtatatga
    13921 ttctcctcta gaattaccag ctcctttatt gaatattact tttgcttttc tctgctcata
    13981 cattcgttat acctccaatg atattattgt ttaataatac catactaaga gcttgtagaa
    14041 aagacactca ataattcaag tgtcttttta tgtactgcta tttaattgat tttgctgttt
    14101 cattttgcac tatatcaagc ttagtataca atgaggtttg accattttct aggtcttcaa
    14161 ttctaaaatc aatacgacta aaacattcta aaagtccctc aacattagat tttattttat
    14221 cttgtgtata atcaaattcg tcaagtttgt catttaaaat tttaatactt tcctgtattt
    14281 ctcgtagcaa ttctaatgtt ttctcatcca ttttatctac tcctatttaa ttgattttaa
    14341 ctttgctatt tcattccaat ttttagatgt agccatttct acaaagttca tgtcattttt
    14401 taaagtgtct attttttcgc caacttctgt tataccttcc atatttctag caacttgatt
    14461 ataagttaag tctagtttct ttttaatttc ttcttgtcct tcttttaaat cactaagttg
    14521 gttttcaatc ccatcaaaac gaccatccat actatctagt ctagtattaa tccattttat
    14581 ttctccttgt atatcattaa tactagtatc cattttttgt aataattcta atattttttc
    14641 atccatgccg ttcacactcc tattttatta ttatatcata atttaagtgt tgtattctaa
    14701 cacttactaa aataatctaa taaataataa ataattttag taaatattag atagtttata
    14761 accatgtagg tgtcaagcag tacaaactat aattttaatg ctcaatcttt agtacttttt
    14821 ataacgcagt acctcacaac tgctatgtca tattaaattg tattgagtgc cattatagaa
    14881 gcaactaagt tgatacctca attttttgta ggctttaatt ggaaaccttt attaatttta
    14941 tttatttaat tacttaatgt tgggaacacc tcaccaactg gtatgactaa ttcatttttg
    15001 tagttaaaaa atgaagaaaa aactatgtgt aatatttgtg ttgtgtgcct ttcaccattc
    15061 acaccattta aaaggtcaac ttaaaggtag taatttttta atagtagttt aatatttttt
    15121 aatagaatcc tttaagatat tagctttaga gttttaagaa ggttctttgc ctgttacttc
    15181 atttgagagg tggctttgtg ttttcttgtt ctcctttgct atgattcaat tatacaacca
    15241 aaaagggtgt atgtcaatat aaaaaataaa aaataatacc gaaaagggtt tgaatgtttt
    15301 atagtactaa cctttttggt gttgtttaaa gttatcttat atgatattat aaatgtaaaa
    15361 aagaaggtga gaaaatgaat agactaaaag aagttagaaa agaaagaggc tataatatac
    15421 aagaaatagc cgataaacta aatgtagctt ataatagtgt cttaaggtgg gaaaatggta
    15481 atagaaaaat agatatagat aaattagttg agttgtctaa tatatacaat gtaagtatag
    15541 attatatatt gtgtaaaaca gatttaaaag agaatataca actaaaagaa gaagaagtca
    15601 atctattaga caattataga gagttagata ctaagagtaa aacgatagtt caagaacaaa
    15661 taaacacatt aaaaaaacta ctgtaagcta gacatatata ctctagctta tttttatatt
    15721 taattttaaa gattaaaggt ataaacataa ggtgagtgca ttgaaatgtg cttagaatgg
    15781 atttaaatgg cttgtacaat atgttattat aataaaatag actagattat agctagtcta
    15841 ttttatatta ttaaattatt ttatttaatg ttaagtacta ccttgagtag attatattac
    15901 tatatgtcaa gtagttcttt tgattctata tctaaatagc tacatatttt ttctagttca
    15961 cttactgtaa attgattctc tcctttttct tttctgtgat aatttcttaa agatatgtct
    16021 aacattctag caatatcctc ttgagaatat tttttttctt ttcttatatc aattaatttt
    16081 tctaatttca tgctatcacc tcattaatat tataacaaaa aagagttact tatacattaa
    16141 gcaactcaat aaagatatta aagataaaca atatatattg ctctaagtgc aaaatataag
    16201 aagaataata aacctagtat ctttattatt tttaaagtgt ttttaatatg ttgactcatg
    16261 tcgtcacctc gtttactttc aatattaggt gtgttacaat atacctatag agatatattt
    16321 ttataggtat attgcattgg ttattaatgt ttaattatgt atataagtat taataaccaa
    16381 ccgatacaag aacataaaga aatcaaaata tgttcaagtg atttaaatac ttgtacaaag
    16441 agcttttcaa gttggtggca caactcgatt agctctttta ttttgccttt tgttattctc
    16501 ataacgtcac cccctaatat tgaattgtat agataagatt aattcttatc ttaattaaat
    16561 tatatacaat aatgacaaat ttgtcaagaa aaatatggca atgaggttgt gagttgatat
    16621 tcgacgatgt cagattaatg ctaaaatgat gtatataaga ctttataatc cataacaaaa
    16681 aaatttattc tatagcaaat aatattttat atagatatca ataactaaaa attgaaatgc
    16741 agtgattaca acaggtttgt agtctaagaa ttataatgac tgacatttta ctgacaaaat
    16801 agaaggtgta ggtgttgtaa gtgtttaaaa tactaggttt tagaaaaatg gcataaaata
    16861 cttaatttta tgccattttt tgctgacaaa aacatagatt tttaaaataa gataaaagta
    16921 atacttttat taattaaata aagtaaatag agtgttttac atattaaaat aaataaaaat
    16981 gaagtagggg gtattttatg gaaagtggct tgtttgtcag taggattttg tgtgtagtcc
    17041 tttcatttcc acatttcaaa aaaattgcag acggatttac agacgaaata gctctgtatt
    17101 ttcctcataa aacaaatatt tatctaaaga tatttcttag atttttactc ttaaattaca
    17161 ttcttaacaa ggaaaatata aaataaaagt gtatgtattg attacataaa aacaactaat
    17221 atatataaaa atattaaata caaaaaataa cttgaaatat aggaagattt attaaattag
    17281 aatgaaaatg tcgtctgtaa gaaaataagt ttcaatattt tacttaaaat taaaattgac
    17341 atctaaaaaa acataaatag tatagttaaa gaaattgatt tattggtttg gaaatagttg
    17401 atatataatt taaatattaa ctaaaaattt ttaataataa attattggtt taaatttaaa
    17461 ttatatatag ttctaattta gtgctaattt taactaataa ctaaaaaatg tcattttata
    17521 gttgaatttt tgtgcaaatt taatgtaatt atcaagtttt tatatggtat aatatattta
    17581 gcaaatattt acttaggagg aatgaaaatg gaagaaaatt accaagttat aggcttagat
    17641 ataggaagag gatacgtaaa aggatatagt aagtacaatg gaatggttaa agaatgttta
    17701 ttcaaatcag tatttggtga tggaagaaac atagattttg agaaatatga aaatccaata
    17761 tacatagatt ttgaaagtgt aagttacttt gttggttcat tagcagaaaa agaaagtata
    17821 acacctataa gaaattctga tgattctaaa gtatctttta caatgagaat attagttgct
    17881 gctgctctta atgaaatagc tgtagctgat gaagtaaaat tgatgatggg cgttccatat
    17941 aaatcattta ggaaaacaac attaaaagaa gttgtagaca catataaagg taaaacattt
    18001 aaagtaaaag ataaaataaa aggtggacat aaagaaataa aaatatctga tatatcaatt
    18061 tttagagaag gagatgctgc attatttcat acattagaag gaaaagtaaa tgaagataaa
    18121 gcggttggca tggtttcaat aggttttaga agtactgaga tgtctttctt tgaaaaaggt
    18181 tttgtattta atgataaact atcagacaca ttagaagctg gaaatcaaga tgctttaaca
    18241 atggttcaga agcaactaaa agatagagga ataataagag aacttaatga gatagatagt
    18301 tctaatgatt atgatgaact taagaaagtt gcttacatta tggcttctga aagcacagct
    18361 caaagaatat cttctaaatg gaagaacata gatgaaatgg atgtatatgt aagtggaggt
    18421 acagcattac atatgacatt cgataataga tttaaagttt ctaaagatgc acaaatggct
    18481 acagctaaag gattatttga agtaggtatg gaacaattct aggagtgata ttatatgaaa
    18541 aaatcatcta gcttttattt agaagaagat atatttggtg aaatagaaaa gtatcaaaat
    18601 gataaaaata taagcagtag aaatacagct ttggaaagaa taatattaga gtggaaaaat
    18661 cttcaagaag aaaataaatt attaaaacaa tgtttaggca atggtgtata taggacaaat
    18721 aaaaagacaa atgttactga agaaaaaaaa gatataaaaa gagaaaatcc tattattaag
    18781 aatatattta ataatatgcc agattaaaag aaaatatcta ctcaagaaat tttgggtaga
    18841 tattaaaaaa aatattgaga acatagaggg tatatgatat aatagaaata gaacatagag
    18901 ggtaatgaaa tttctgaagc aacatgttgc gaagaacaat tgcaagatga tttttatctt
    18961 gtaattgaaa taaaatttat aagaaaagag gtagatattt atagttagag gtaatgaatt
    19021 tataaaagat gttattgtaa cagacaaaag aacaggagaa atattggagc ataaagggat
    19081 gaaaagaggt gaggtacttg aaattggaaa gagaaaaaag agtttttctc cagagcaaag
    19141 ggctattatc aataataaaa aagaattacc ataccataat tttaaattag gaggttttgt
    19201 attttgtact tatgttaaaa atgaattatt atttaatgaa gtaaatataa gtaaagctaa
    19261 tataagtaga ttaatatatc tcgcaacata tctaaactat aatacaggag aagaaaattt
    19321 attggttaga tattctcagt ttaaagaaat gattcctata gatagaaaaa acatgagaga
    19381 aatattaaat cttaaagata gggcatttag aaatttttta gcagacgtaa aaaaatgtga
    19441 attattatat gaatctaata ataaatttta tataaatcca aagtatttta ctaaaggaat
    19501 tcctaatttt gaaaataaag aatatacaag aatatatata aatactagta gatttctttt
    19561 tgaacattgc acaccaagac aacataaaca attaagttat atatatcaac tcataccata
    19621 tatacatttc gagagtaata tcttatgttt aaaccctcat gaaacagata tttcaaaaat
    19681 aaaaaaaatt agtttatata aaatttgtca attattaaat attagtacaa taaaacaaga
    19741 tatgaacaaa tttaaaaagg aattacttag attttatata aaggtagaag atgataaata
    19801 ttattttttt aaatatgtaa tcgttgaagg gaataacaaa aatacagact atttcattat
    19861 aaatccttgt gtaatatgga agggaaataa tttaaattta gcaaagaaaa caattgattt
    19921 atgctttttt aattgtattt agaaagtctg tctaagaata agaggtaatg aactgtaaaa
    19981 attaacaaaa atataggaaa aacagttaaa aaattaaatt taggggtggc acagaaatgt
    20041 gaccaaaagg caaaaaaacg gcacagaaat gtgaccaaga aaattaattt aaaatcttat
    20101 aatatagaaa aggagaagta tgaaagagaa aaaaatagaa ttaatatatt tagaagattt
    20161 agatgaatca gagaaaacag gcgtacataa aaataggtat caaatattaa atgaggaata
    20221 tgaacaaatg atagatacat acacagagat gagtaaaagg tcttcatatg atattgtaaa
    20281 tgaaaggcat aaggaggatt ttaaggatga actatgggat tatgatgata cagattatga
    20341 tgatggattg caaggaaagg aggtataata ttgatatata ataataacaa tttttatgaa
    20401 gaaatagatg gcaaatctgc acaagattac ataaagaatt tagattatag catagacaat
    20461 agcaaagata gaattaaata catagaggaa cgattagggg taaaacacac gtggtttgaa
    20521 gagtcaaata gaaattatat agatacattt tataatactc ttacaaagag aaatgagaat
    20581 attattacta gagtgaaata tcaagaaaaa aaacaattca atgataaatt ttgggaaaat
    20641 atatttgagc aaacatcaga tagtccttta gataaagatg gtgtatatta tgttactatt
    20701 gatggagaag aagtagttat ggattataat agattcatta cttggtgtgg ctataatcaa
    20761 attaatccaa tcgaatatat aaatgttaaa aatcctttta gtaatagtaa tggtacatgg
    20821 gagtacacac atcataatac atcgaaaatt aagttgatat taaataaaga tgacagtata
    20881 tattctactt ctaatatagc aaaaacatta gaaataatgg ggagctatat actctcagta
    20941 gatgataaac ctaaggaaac taaaataaga atatacaatt caaaagagtt atttaataga
    21001 gcatgtcagg aagaagcact tctaaataaa atagcacctg caaatggtgg aaatataaat
    21061 tcaaacactt ctaataaaga tggattccta gaagacaatt cctttgcatt ttttcaatta
    21121 cctaaaaact ataaaaaaat aaaagatata aaagttaaac ctaaagatat taaaaaatat
    21181 ccaattataa aaacatactc agatacttat gaatggtata aagctaaata taaagaatta
    21241 ggacataaac aattaagtaa agaagagtta aaacttaaga gaatggttag gaaaaattta
    21301 aatgcattaa aaaatgatat gactgatgtt aaaaattcta tagagagacc aattatatgg
    21361 aaagcaccat tagcagatgc aggaagccca gaatgggact atttagatat gtttgataaa
    21421 tcacatgtta aagagctttt aaggattcaa aagggtaatg atttgcaaga tgatttaaca
    21481 tgtatagtta tggatttaaa taatattata tctaaaattg aatttaccac agtacaaaaa
    21541 gatattttaa atttatatag aaaagataaa tcattagagt ttatttcaaa tttaatgaat
    21601 ataactcctc aagcaataaa taatcaaata aataaaatag tgaacaaaat aatagatgca
    21661 tatgagaaaa actatgaaga aaattattat tatatatctg tttgtaaagg aaaatataaa
    21721 aaatgtagca gatgtggaaa aattaagttg ctatctaggt ttgataaaaa tggtaaaaag
    21781 ggatatcgct caaattgtaa aaactgtaat tagctggtgg ggaaaagtgg tttaaaaaag
    21841 ggtcgcttaa aacatattac ttatgtaagg ggttaataaa aataataaaa ttattcctta
    21901 ctattatcaa atgaaaatta tataagaaaa gggagattaa gaagatatga aaaaagtaga
    21961 ttttttaaaa gaagtagcag aagaattagg tgtatcacag ataagagtaa gagagatact
    22021 tgatgtgata gaaaaaaaaa gaaacgaagt actacaagat ggtgaagaat tgacgttgat
    22081 gggagttaaa tacctaacta aaatacaaaa aggtaaagaa ggagaaataa ctcttaaaga
    22141 tggaactaaa aaaccttgga aaactgagga aaaaagagtt ccaaaattaa aaatagctaa
    22201 atctttaaaa gatgcaatta tatagagagc gtatgggtta aaagcccttt catatggtga
    22261 catatggtag caaacctaga atatgctaaa aattaataca attagcagag atagctcatt
    22321 ttgagaagct ctagtggctg gtaataggta tcttatattg taagatgatg atgccactaa
    22381 aaatattaaa ctacaacgtg aaatttgtgg gataattact caccatttca aaactggaag
    22441 aaagcacatg tcgtgagata gcagtaagtc tttcttcctt ttaaataaat actaaaaggg
    22501 agatttgata aaatgaatgg tgaaaaactt atagaaaata aagaattaag agatagaaat
    22561 atagatagag tagatgtatt ggaacatgtg aaagagatat taactttagc aaatacagat
    22621 tttagtacag tagaacttgt ttctgagtat tatgaagtag atagagatac aataaaaaaa
    22681 cttatacaga gaaatagaat tgaattagaa ttagatggtc ttaagttata taaatacaat
    22741 gatatagctg aagtacttga aaatactaaa aagggactgg atgtcacttt taaaattcct
    22801 ccaagaggtc taatattaat acctaaaaga gctattctta gaataggcat gttacttaga
    22861 gattcagaag ttgctaaaga agttagaact agattactag atattgtaca tgatgcagaa
    22921 gaacaaactg aaattgtaat agaagaaatt agaaatgaac aaaatataaa agaagacatg
    22981 cttgaagcga taatttctgg tgaccataat aaattatctg tactacagac agaattaata
    23041 gggttgaaga ataaaagaat atctcattta gaagatgtta taactaattc agtcactata
    23101 acagaaagta aagctattat taataaatgt gttagaacaa tagcagttaa aaaatttaat
    23161 tgtatgtttg gtaaagcatg ggatgaattt tatagattta ttaactataa acttggcatt
    23221 aatgttagaa atcgaaaagg taaaggatta gctagatttt cagatgaaga aatcttaaag
    23281 atggaaaaga tagctaaaag ctggttagag gaaaatgata tagattttaa attggtaata
    23341 taatttaaat ttgttttcaa aagggatata gctcaggtgg ttagagcatt cggtttatac
    23401 ccgaaaggtc ataggttcga ctcctattat tcctagcaaa tatggagagg tactcaagcg
    23461 gtaaagagga tagtttgcta aactattagt tcaattaatt tgatacgagg gttcaaatcc
    23521 cttcctctct tccaataaaa agagtttgtt atttttaaat aatattttaa ttaaaaggga
    23581 gatgttttta tggttaaata taatgtacac aaggctttag cagaaaagaa gttattagaa
    23641 gataaaatag atagatgcat taataatttt aaaattgtag gaactaaaaa agggtctgat
    23701 aaaaatgtat atgaaacaaa aacaagtgta gaagatttta atgtagaagt ttcaagtaaa
    23761 taccaacaaa tagaagattt aatatataat tataacgcat tagataaagc aattaatatc
    23821 tctaatgcta taacaaatgt tcaaattagt aataaaaatt atacagtttt agaagcaata
    23881 aaaagaaaaa atagtataga attagataaa tccttgttga gacaaatggt tagtaactat
    23941 gattgtatga tgtctgaagt aaatcgtaga aatgaagaag tgcaaaaaaa tacagacaga
    24001 atgtttgagg aaaaagaaaa aagtaaagat ggagcagaac ttatttcatt ttataaaaaa
    24061 caacaagaat ggtctttagt agacccttta aaagtaagag agaaaataga aaaattaagg
    24121 gatgaaatag aagaatttga aaaagaagtt gattttgcat tgagtacatc aaatgcactt
    24181 acaattatag atgtagattt aagatagtcc ttaattggac tattttttaa tttgcaggtt
    24241 aggcgaataa cataaattat aagttcccat ttggttttgg gttaaaaatc aaactgctta
    24301 tataaaagtg atgggtacat acaaacgaaa cgattgtact gtataaaaga gaacaataga
    24361 tataaagctt aaagttaaaa attcaaatat aaaatctcaa ggataaaaga ttaaattatt
    24421 aaaatagtaa aaataaaata aaaaagttat agaaaatcct tgataaatgc taaatgcgtt
    24481 aacttatatt agctattgtt agctacaagg ctgcctaatt tgcaaataaa tatattccca
    24541 gtagagttaa taaaattata aaaaaggtga aagtgcatga aaaataataa aggaacagta
    24601 ttagaaaaat gtgaaataat aaaacaagaa aataatacat ataaaattat agaacatttg
    24661 aaagatggag accatgaagt attacttagt gatgttttgg ataagtatac tggtgataca
    24721 gatttaaaca taacgataag attaagtgaa acaatagtcc aataaatcaa tattggacta
    24781 tttatttttt acttaataca ttgataatga tatttatgtg ataaataggg agatattaaa
    24841 tatggaagac atattgaaga aaaaagaaga tgagtcacta gttgactata ggattagaat
    24901 acgactagca aaggttaata aagagataga tttggattgg ggagagatag ttgaactatt
    24961 ggggttagaa tgttctccag accattgtag gaaggtttcc tatgggttga aagaggcttt
    25021 tgattatctt aattctaaga tacagaataa ttctactcaa gaagagattg ataaaataaa
    25081 tgagaaaata ttagaattaa aaaagataaa agtacaacta tctgatgaaa ggtcattagt
    25141 aaataagaaa ataagagaat attcaagaat agataatata attgatttat ttaataataa
    25201 aatagatgat atatcacttc ataagccatt tctaagtgat tctagttaca aatgctatga
    25261 atcttcaaat caagaggcta ttatgctaat ttcagacata cattatggat tagagactat
    25321 taatgcattt aatagatata attcaaaaat attcaagata agaatacaat atttaaaaga
    25381 taaaattatt gaatatagta agttacataa agttaagaga ctgcatgtaa tgttacttgg
    25441 agatttaatt tctggataca tacataattc tataagatta gaaaatagag aaaatatagt
    25501 tgaacaaatt atagaggtgt ctgaaatact tagtgaattt atatatgagt tatctaaaga
    25561 aattgataaa attattattt attcagtagg tggaaaccat gatagagttc ttcctaaaaa
    25621 agatgaaaat ttagataaag ataattttac attattaata gatgaatata taaagctaag
    25681 aattaaaaat ataaacaatg ttatatttca agaaaatata tatgataatg acataatagt
    25741 ggctaaaata tgtggaaata cttgttttgg agtgcatgga gacaaagata aaatgtctac
    25801 agcaattcct aaactgacct ctcttataaa attaattcct gattatatct ttatggctca
    25861 tctacacaat tgtaaggaag ataattatgg agaaagtgaa atatgtgtaa atggaagttt
    25921 ctccggaacg gattcttatg ctaagaatct aagattaagt tcacacgcaa tgcaaaaatt
    25981 aatgatattt aatgaaagtg ggagaatatg tacttacaat ataaatttaa gtaagctata
    26041 agttatttat taagagctga gttaagttta tattgtaaat ttaattcagc tcttaattga
    26101 gttgaatctc cctattaacc actagagatt taattctcta gtggtctttt ttaatggtgg
    26161 tgatgttatg aatggcaatt agtaaaacaa agtgtttgaa ttgtggtgaa gaaaaatata
    26221 cagatagata tttttggaaa agtcatagtg aaatatttac tttaaataaa agacttccag
    26281 tatgcaaaga atgttttaga gctaggtttt tactattaaa tgggtgttac aatggagaac
    26341 ttgtaaaggc actaaaacat atatgtttca actttgatgt ttattttgat gaaaaattag
    26401 ctaaagaact tgcagataaa aaaaataaag atgaattaat agatgaatat atgaaaatta
    26461 ttaatagaaa ttcaaaatat aagggaaaga catctttaga taatttattg aaagaaatat
    26521 atacaggaaa taataatgat aaaaatatag tcataaatga tgaaattaaa ttaaaatggg
    26581 gaagaggttt tgatgattat gagtataaaa tcttagaaag aaaatataag gaatataaag
    26641 aatattatga accagagtca ttaactgaaa gaaaattgtt tgaagagatt tgtattattg
    26701 aattagaaaa agataaatca agagaaaagg gagatatgaa agcttttaat gatttatcta
    26761 aattagtatc aagtaaaatg caagatgctg aaataaagcc tagtcagaaa aagaaagctg
    26821 gagattcgca agatgataca tttggaatga aaatgatgat atatgaaaaa aatcaacctg
    26881 taaaggatag gttaaaggaa tatgaagatg tagatggatt tgaagcttat gtaaataaac
    26941 atatgaaaaa accacttgct gttgcattag gtttagctac aggtaagtat tcgataaatg
    27001 atggcgataa agatattaaa tttaaagatg atgtaagaga cattttagaa ggtaataaaa
    27061 atgaggacta aatatgaaaa aagagagctg tcatctaatg attcatcccg aaatctacta
    27121 gagagtatag gagagtattg gggtgctttt tatctcgcaa atccacatag attctgtatg
    27181 gattactttg gatttaatct acatttattt caacagatat taatttatat gatgatgaag
    27241 tctgaccaat ttgtatttat tgcttctcgt ggactgggaa aatcatggct tctaggagtg
    27301 ttttgttgtg ttatagctgt attaaaacca ggtacttgtg ttttaatagc agcaaaaaga
    27361 aagaaacaag caaaattact tattacaagt aaaattttag gtgatttata tttaaaatca
    27421 gatactctga aaagagaaat taaaagtttc caagtaaatg cacaagaagt atctatagat
    27481 ttttggaatg gaagtagaat agaagctgtt gtatctaatg atgatgcaag aggttacaga
    27541 gctaatgttc ttattgttga tgaatataga atggtggatg aaggaactgt gaatgatgtt
    27601 ttagttccat ttttaacaaa cccaagacaa ccagggtatt tacagaatcc taaatataga
    27661 tatatgcaag aagagaataa agaaatttat cttagttcag gctggtattc tcagcattgg
    27721 agttataaaa agtttatgga aacagtaaaa ggtatgctta gtggtgaaga tatgtttgca
    27781 tgtagtattc cattcacttg ctctttagaa catggactat taactaaaaa aagaatactt
    27841 aaagaaatga aaaaagagag tatgagtgat gcttctttca tgatggagta ttgtggagtg
    27901 ttttataatg aatcagatga tgctttcttc aagtcatctt gggtgaatcc atgtagggta
    27961 ttagaaagta tgttttatcc tcctagtgat atagagtatc ttgaaaataa gaaaaaaaga
    28021 gataagaaat atcatcttaa taagataaaa ggagaaatac ggattattgg tgcagatata
    28081 gctttggcca gaggagttaa gaatgataat tctatttata ctttgatgag gatgcttcca
    28141 aatgaaggca catataaaag atgtgttgtc catatagaag cttataatgg tatggaagct
    28201 gaaaaacaag caataagatt aaaacaatta ttttcagatt ttcaggcaga ttatatgata
    28261 ttagatacac aaggtatagg aacaactgta tggagctata tacagaaagc aaattatgat
    28321 tcagatagag atgaatggta tgatgcttac acatgtttta atgaagataa tactgttgac
    28381 aagtcactag caaaaaaatc acttcctgtt gtatattcca tgaaagctta cgctgatgaa
    28441 aatcataaaa tggctatgtc tttaagagat gtccttacaa atagaacctt agaacttcct
    28501 ataagtgata ttgaagcaaa agaaatgata ttagaaaaag aaatgataaa ggcagatgaa
    28561 atagataaaa aggcagaatt agaagcaaaa tatattgccc cttatcttca aacaacggct
    28621 ttagtgaatg agttaataaa tttagaatat agtgctgatg gaggaaaaat taaaataaag
    28681 gaaaaaagtg gagcaagaaa agatagatat tctagtttgg cttatacgaa tttcttagca
    28741 gattatctgg aagaaaaaga gaaaagaaaa aatagaaata atcaaaaaac tgttatgatt
    28801 tattggtaag agatgaggtg aataagtggg caaaaaaaat aataataaaa gcaagtctaa
    28861 agacaacaat tctacacaaa atcaaatcaa tatgctaaat gctcaaattg gaaaatatgc
    28921 ctcagtaaaa gaatccacaa cattagcaac agaaatgtat aagttaagaa gtataagcag
    28981 agacaaatta agaaaagctc tctccaatcc atatcaaatt tcaaatacag atatacttca
    29041 ggatgcaagt atgatattaa aagctacatc tggtacatat agaagagttt taaatttaat
    29101 atctaatatg aatacttttg accatatttt atacccaaaa gacataagta gattaaaaac
    29161 aaaagaaaaa ataacaaaag catatatgaa ttcggcgagt caattagaaa aatataatat
    29221 aaaatttaca tcagcttgga taaccgaaaa agtattggaa ttaggagagg tttatttata
    29281 taagatagaa gataattcag ggatggtttt acaacagata ccagcaaaat tttgtatgat
    29341 aacaatgata gaaaataatg taatgagata cgctataaat ataaaaaaac ttactgacaa
    29401 aaacataata tcctttccag aagaaattaa aaacatatat aaaaaatata aatctaattt
    29461 acttacacga gaagaattaa ttgataatac atattttcaa ttaagtgata aagcagtagc
    29521 atttaattat gatttagatt cagtgaaagg agttccattt ttttgcttta tatttgacga
    29581 tttaatggag cttgaagata tgaaagattt aaaaagcaca aatgcagtaa tagaaagtat
    29641 taaattaata catcaaaaga taccatttgg caaaaatgat gaaccactag tagaccttaa
    29701 tttaattccc atataccaca attcaacaaa agcaaattta ccaaaaggaa cagcaataac
    29761 tacaaatcct ttagagttgg aaacacatac tctttcagat ggaaaatcta aaataaatga
    29821 ttatgtaaaa gaagcaaaag agttcatatt tgataacgct ggaataaata cagccttact
    29881 taactctgac aagataaata atgaatctat cttaaatggt attattgcag atagcttaat
    29941 tcctatgagg attcaacaaa tgatagaaaa ttgggttaac tttgaactaa ataaagacaa
    30001 gaaggcaaat ttatttaata tgaagtttat tggaactact cactttaata aaatgaattt
    30061 atccaaacag tatcgagaag atatgggata cggagggagt aaaagcttgt ttattgcaag
    30121 tactgggttt actccacttc aagctataaa cactttacaa gcagaaaaat taatgggatt
    30181 tgatgagttt ttaatacctc aacaaacatc tcatactcaa agcagtggta gaccagataa
    30241 atctgatata gggacagata atggtaattc tactcaagca aaaggaaatg gggagaatga
    30301 ttaattatga gtaagtttat atatgctttt tctgaagatg ataagaaatt attaatggaa
    30361 aaaggatatc gttttatatg tgaaaacaag ttgaataata agactttata tgtttttgaa
    30421 aataaatcaa aattaataaa taatttcagt aatgaagaaa tgaaaagatt tatatttact
    30481 agcaaaatac gtttttaaaa ggaggtgaaa aaaataaaaa tattaaaatt accttgtaat
    30541 ttaaaacatt attcagataa aaaaaaattg gaagaactaa atagtaatct tttgccagtg
    30601 tatatctatg ttatgcatga aggtacaaat ccaaatggaa ctaaatttta tgaagaagct
    30661 attgataaag ctgaaccaac attaaaaaat gttccaattc taggatatgt aaaaataaat
    30721 gaagatggaa aatatgactt tgatggtcat aatgttttaa cacaagtagt tcaaacagat
    30781 gaagggttta tattagaaga atattatgaa gaacgaataa ttggcgttat accagaaaca
    30841 aataaatatg aaaaagttga aattgatggg cagaagtatg ttaaatgtaa aggatatata
    30901 tataaatcat atagcaatca tgcttacgat ataattatgg attctgatga aatagaaatt
    30961 tcaatggaaa tagatataaa tgattatcaa ttagatgatt cagatggatt ttataatata
    31021 aaagactatg tatatcatgg aattacatgt cttggttctg atgtaaaggg agctatgggt
    31081 tcaaattgtt gtttaactaa attttcaaga aaaattaatt ataaagaaga aatatcaaaa
    31141 atatgctcag aaatttatgc attagaacat ggagaggggg aaaagaattt gccaaataag
    31201 aatcaaaaac ttaataaaaa ttctgaagga tatgctttag cagtgagtaa tcttagtact
    31261 gaaataagaa ataagttaaa agaatacaaa gtcgaaactg agaattggta tggtgaaaaa
    31321 gttgaagtac aagcttttta ttataatgat ttaataccag aagagaatat tgctatagtt
    31381 gaagatgaaa ttaactgggg gtattattat ggtattccat atatagttaa tgaagatgct
    31441 gtcattttgg attatgaaaa taaaaaatca tatatacaaa cttggaggga aaaacaagaa
    31501 ggagaaatag tacaggtttt tagtagacaa gaaaaattaa aaaaagaaat aatagagaaa
    31561 tttactgaaa agcaaaaaga aatatctaat ttaaaagcca gtttagagcc attacaggca
    31621 ttcaaagaag aaaaagaatt tgagttattt aaatctaaag ttgatgatgt agctcaaaaa
    31681 tttgaattag cagaagatga aattaaagat ataaaaataa aagcttataa taaggaaatt
    31741 acattagatg aatacaagaa agaattgggt tacatatttg cattaaaaac tcttagcaat
    31801 aaacaaagcg aaaaggaaaa ttttagtata aatgatgata aaaataatac gataaaaata
    31861 cctataagta ataataatga tagttttagt gaaccagaag aaatatcttt tataaaaaaa
    31921 tattcagata aagaataata ggaggaattt acatgaagaa agataaagca ataatacaaa
    31981 cagataaagt aaaaaatcct gatgttttaa caggtaaata tgttgttcca tcagaggata
    32041 ccaatccaat aaatttagaa aatggtgctg taataaatat tggagaactt gaagacacgg
    32101 agtatggtag ggatacccat aaaatatata aagttacaaa tgacacatta gattggggta
    32161 tagttgatga cccagcaact atgtatgatg aaagattaga tgaaagagat tacgaagttt
    32221 ctcctggtca gatatgtaga tgtagacgac taaaaaaagg agatgaggta actatatctc
    32281 tattacatat agcagataaa agtattgcag taaaagacaa gttacaatta aaatctgatt
    32341 cgtttcagtt tgaaaaattg cctacagcag atgctaaaac tccagtagca gaagtattag
    32401 aattatggaa ctatgaaggt caagattcgg ttacaataaa agttttataa aatcaaataa
    32461 aattaacaaa caggagataa cagtctataa ctgttatttt tttatgcaaa aaaatagaaa
    32521 aggaagtgtg taaattaatg gcaacagcaa aaactttaaa gagaatagct catgagctat
    32581 atacagatac atttagagaa tatacagata gagatggaaa cacaataaca tatagagatg
    32641 ctgaaagtgc aataaagaat aaattaaaag aaatgatggg aggagaaaaa tataattatt
    32701 ataaattcca agaaaataaa tggggatttt ataatttaat atcagaatta atatctgatg
    32761 atattaatag attaaatgag gaagtattta gtccgttttg tgattttgag aactttgatt
    32821 taggagataa aaaagaattt actgttgaaa atactaattt atttaaagtt gcaaatatag
    32881 cagatggtgt taatagtaca agaagacaaa gattacttaa taaaaaagtt cctacaacag
    32941 catttaaatt atctgttgct atatatgaag aagcagagag atttataaca ggaagaataa
    33001 attgggttgt atttgtgaat agggtatcag attcatatca ttatgatatt gctagaagaa
    33061 tagcgaagac atttgaaggt gcatattcaa caataaatgc taagtttcaa gctacaggta
    33121 attcagacaa agtattattg gaattgatag ctaaggtaga aggggctact ggtaaaaagc
    33181 ctattatata tggtactcca cttgcattaa gtaatttaga aggtgttcaa actgatttag
    33241 aaaaagaaga aaaaagaaaa tatggtttta tacaaacatt tagaggtgga tataaagtac
    33301 ttagtttacc aaatgcttat gatgaaaatg cagcagaagg taaagagtgg gctttagata
    33361 ataaggctat ctatgtaata cctgatggag agaagataat caaacttggt actgaaggag
    33421 atgtattggt catagaaaat actgatgaaa aagaaagaga tgaccaacaa atagaatatt
    33481 ttatggctca aaaaatacat ttaggagttg taactgctgc taaatttgga gtttataaaa
    33541 tacaataatt gaattagaag gtggttatcc accttctttt ttttatggga gggagattat
    33601 tatggcaaga gctaaaaaag aaaatatttc taaaacagaa gtcaaagtta atactttaga
    33661 aaaagatata aagtctactt taaataaaaa agaagctaga ttaaatagat tagaactaca
    33721 aagaaaacta aaacaaaaaa aacaggaaat agatatagaa ataaaaaata tatccacatg
    33781 ggatgttgat tatattgacc caagagaaaa acaacagatt ttttctttat ctaaagtagg
    33841 ttcaaaagat tcaactgaat ttatagattt agatactctt tatagaatag taagaagaag
    33901 tccaggtttt tttgaagaac atagattaat aatttcggat gtagattctt tagatgttga
    33961 atgtactcca atggacataa tagattttct aggattgaat agtttatatg aatatataag
    34021 aaatcctaat gaagactatt tagaatattt cttatctgat aaagttgata taaattcttt
    34081 tgaaaaaata ttaaataaaa ataatgttga gttaacaaga agattagctg agagggcaat
    34141 agatttacat aaaaagaaaa agtttgattc tgggctaaag gctaaactat tagctaaaag
    34201 aattggaatg gaagatttgt acttgtttag ttaaaggtgg tggaatattt gggtacacca
    34261 cttgtaaaaa tatataaaaa gtttttggat ggtattaatg atgaagagat gttattacta
    34321 tcaaatgaaa taatagaaaa aatgatgtac agttatttag aagatgctat agttgatttt
    34381 aatcaatgta aaaaagattt gactataaaa tatgttgatg aaaaaggtgg agaaattatt
    34441 cctgctgctc aattaagtta tacatctaat tatagtaata aaaatgcaga gataactttg
    34501 atgggaaaag atacaaaaga agaatacgaa ttagataaag attatacaat aagctttgaa
    34561 gatgaaaaat ttataataag ttttgttgta gaaactacag aagagataat tttcaaatac
    34621 aaatatttag gagaaatagt atctgattta gatttagatg aaattaaaat attatcatat
    34681 ggtatgcaaa tacattggtt acaacctaag ataaatagag aagaaaattt aaaacagatg
    34741 ctaactgatt ctgattataa tgctaaatca ggtgctaata tgttggctaa acttcaagca
    34801 agagaagagc aattgagaac tagatttaat aaatatcaac aaagatacat gctaaaaaat
    34861 tttgaaggat ggaactagca tgagttactt aagtgataca aaaaaaagaa ttggacttgg
    34921 ttgttcaact cctaaagaaa aaagaatatt acaacttaga ttaagtttta agaaatatct
    34981 aaaagaaaca ccaacctgta ttgaagtacc aataactgat atagatgaaa tttgtataac
    35041 agaagatact aaaagagcta tagttgcaat taatgatata actaataatg ataaaagagc
    35101 tttagatgaa aaaaatctat tagttgaatc tgatttagat gtagatgtgg gttgttatct
    35161 tttctatgat aattgttatt ggttaactat atttaaagaa cataaagaaa tggatacata
    35221 taaacatttc ataataaaaa gatgcaatca attctttaat tataaatata aaggtcagat
    35281 gtataaaatc cctatagctg ttgaaaattt aaccttatat tctgatggta tggcagataa
    35341 taaatatact tctatctcag atacaaaaag acagctttat tttggaagta atcctgtcac
    35401 taaaactata gatattgaca ctagaataat gttaactggt aaaactgtat ttagagttac
    35461 tagtattaat gactttgagt ataatggcag agaaacaggg gcagatggtc ttattaaagc
    35521 tatttgttta caagatgcat tgatttcaaa agatgataca ataaataata ttgcttggaa
    35581 tgatttatct gaaaatgaga gtgtgattat tccttttagt aaaattatgg gtgatggatt
    35641 tattaatcta ggcgaagaaa atgaatacaa aatagaccat tctcaaggag ttgaatggct
    35701 cttagacaag caatacggat attgtaatat aattaatcaa gatgagaaaa aatgtgtcat
    35761 acaggctaat acattggcta aatattctgg ctttgaagcc ttgctattgg ctaaagataa
    35821 agatacaaat aaaacaatag atactaaaaa aataacacta agggggtaga tatatgggtt
    35881 tatatggctt tccctaacaa gatgataagt aatataggag caactctaat gtcaaatcaa
    35941 gacttcgcta aatttatgat ttataatgat gaatcccaaa aagatatttt atccatgcct
    36001 gatataaaaa atcctgttaa agaacttaga aacaaaaaag tatttctaaa tagaagagta
    36061 gaaaaagtat taaaagaagc agatatttca gtttttataa taatgtcaga atataggcca
    36121 tgctttgaag gaagtaggac aattaaaaaa acaaagatag aaattggtgt tgtttgtcat
    36181 gatgaatgcc aaagtacagc aaatggctta agagatgttg cattagtatg ttgtatagtt
    36241 gatattgtaa ctcaaaatga ggaaatagct ggtataggta agattaagtt agaaaatgta
    36301 tatcaaatgt ataatttaaa tactgattat aacggatttg ttataactgt atcagctgaa
    36361 agttttggtg atatgtaatg ttggaaaatt attatatcac aggattacca attaaactag
    36421 gtgaaacatt aggaactgta tatcaaccta ctattgaaga acttattaaa tttgatatgg
    36481 ctaatttaga gatagttaat ccatttttag tacttgaaaa gagctattct cagctatgta
    36541 acgagaaaat atttgaattg aaatgtaaat atgatgctat acctatcttg gattcttctg
    36601 aagaaattga gttacttagt gataagataa aaaaatcttt atctatatta tataaaactg
    36661 atattaaaaa tattgagtat atgaataata ttaaaattgg tattttaatt aaatttgatg
    36721 ataaaaagaa aaatgctttt ataagtagag aggattttgg actggtatca gatttgattt
    36781 tagagatgtt ttgtattgat aaaaagaatt tatttaaaga tgatgaagat aagtggattg
    36841 aaaatactgg ctctgaaaga gaaaaacagt tgattgcaca ctttaaagag aaggaaagaa
    36901 agaaaagaga aaaagaagca tatcacttat gtgattatat aaatgtagtt caaaacatag
    36961 atggatatgt accaatagat gttattctaa aaatgactta ttggcaatta attaatgctt
    37021 ataagactaa gatacaattt aaaaattatg atgaaagttt aggctttgca atgtctttta
    37081 aatatcaagt tgaggcagac aagattaaac attggtctaa agaaataaaa atacaaacta
    37141 gcactgttaa ataacagtgt tattttttat gcaaaaaatg agaggatgat gaaataatga
    37201 gatttgcgat aaaagatgca agtaatataa tagtaaaaaa taaaacaact ggagaaccac
    37261 ttttttatac agcagattta aatgctttta atttcaaatt agattcagaa agcgtgtacg
    37321 caaaagctaa aggtgcaaac acaatagcat ttgatggagc tataacagca agtttagcac
    37381 ttgaacaaga ggtaatacaa atgccacaac tagcaatgct attagcttct gatatggttg
    37441 aagaatcggc taaggttggt aaaagaaaat tactaacttc tgatggtact aagaaagtta
    37501 ctttagaaaa tgtaaaacca gttactaata gtatatctgc atatagtgtt gaaaaagatg
    37561 gtatatcttt agttaagaaa ttacagttta cttcaactgt aacaggctct aacacagaaa
    37621 taacaatatc tacagctgat tttaatgcag gagataaagt agcagtgttt tacttagagg
    37681 aattaccaaa ggcaaaagtt ataaaaataa aagaagagtc tactgctcca aactatgtaa
    37741 tagaagcaga tgttatggct aaaactgctg atggtgaata tatggtctta tatatgacta
    37801 taccaaatgc aaaggcacaa agaagtatag aattaaatct tactgctgag aatccatctg
    37861 gatttaatat gacactagat gttttgccag atgaaaataa agaatatgta gtattcgctt
    37921 ttgttggaga tgaagatgtt agccctgtta gaatggcttc tatgttaggt gctgaattaa
    37981 tagacgaaaa ggatgttaaa tctaagaaat agtgaatttc cctactcaaa agagtagggg
    38041 ttattttttt acgtttaaat ctggttttaa tcggatttga acttaaaaaa atgaaagaag
    38101 gtgataaagt ggtattttta gatgataagt ttttatttga taatatttca agtgaatcca
    38161 tgaacattaa attagttact ttaggtgatg atgaaatact aaatgaatat ggattgccct
    38221 acgaagaagc gattaaatct gatagtactt ttaataaaaa tccttgttac tcagaggatg
    38281 aaactactat tgaacctata acactacaat tctgtttgtg tagcgaacat ggggaggctt
    38341 acgaatggga tgactatacg ctagaaaaca tatgtaattg gttttggcag agagaattta
    38401 aaccttttat cagttatgac aatatagaag aaatatacta tctcaaagcg agaaaaataa
    38461 taaaaagata tacaaaagat aaaaaaggcg tattagaaat agagtttcaa ccatatacaa
    38521 attatgctta tagaagcttt caaaaagtta taactgtcaa ggatacaagg gaaattaaac
    38581 taaataatgt gtctaatgta gatgaagaat atgctccagt aattgatatt gaatgtctaa
    38641 aagaaggaga tataactatt agaaattcta ctatcagcga taatgaagaa gacaatttag
    38701 ttataagtgg attagaatta aatgaaaaaa taacaataga taatttatac tatactgttt
    38761 taaatagttc tggtgagaat aggtttaata ttgttaatag aaagtggatt aggttaagaa
    38821 gaggtgtaaa tatattgaag tttactggaa actgtaaagt ttctattaag tgtaaatatc
    38881 caataataaa ataagggaga gatagatatg aataaaatac aagtagataa attaatacaa
    38941 gatgaagtta gggctataat accaattata gatgagaatg gtaaagagga atatatagaa
    39001 gttagaaatc ctgataagga gactaaagaa gagatattaa ataaaatatg ggttggtatg
    39061 gagaatcctg atttagcatt gtctcaagaa gatattctta aaatgttgat tgataaattg
    39121 actaatatag agttaaatat tgaaatagaa gatttagtag atggcaatat atctagtgaa
    39181 ttagaaaatg tgatgtatta cataggtcaa atagaaaatg aattaacggc atctttatta
    39241 atgaatactg aaattaagct aggtcagatg aagaatgaga tattacagga cagagtttta
    39301 aaagagactg aagaaattga aaaaatgaat aatattaaag aaaaggtagt gaattagatg
    39361 gtatttaaat cattagatga attggttgct tatacaaaaa ataagattgc tgcatctatg
    39421 cctgaagttg gaaaagaaat gaaagagata gtaaaagaag aagtaaacaa acaagtttat
    39481 tctgattacg ctccatcact ttatgataga acttatgaat tacttaatgc aatagatgtg
    39541 tctgaaataa catcagattc tgtagctaca gaaattaaag atagtgggag ctggtttgat
    39601 atatatagca aagcacatgc ttttccaatg gagcgatttg aaaatggagg tgtgtgggga
    39661 catggaagta ctaaatataa tcctgtattt agacctagaa caaatataat ggaggaaagt
    39721 aattctaagg cacaagagag agtaccaaag tgttttaagt ctaaaatgaa tgaattaggc
    39781 gtgccagtaa aatagacaat atcgagtgtc tattaagtta tagagttttc taagggttgt
    39841 atgttatcca ctagtagatg tatatcataa gtggaaaatt aaaaagcggt gatgctctaa
    39901 catatagtga gtaatttagc ctagataggt agtttagttg atttgcttag ataagtggtt
    39961 tagaattgtt tctcaatgtt ctaatacatt gattgatgca aaaatatata caagtatatt
    40021 gtgaaatata cttgtatata acatattgat ataaagagag aggtatagtt gtttcaatta
    40081 acatttaaat ttgaatatat cgaggaagta ttagaagtta caagagaatt agattatcct
    40141 aatatacatt ttagggaatc ttgtggtaag ataatagaaa agtaagaatt aaaaaaagat
    40201 agttttacaa ataataaagt caatattcca aaacatttaa tatataatta taatgatgat
    40261 atttggactg gagatataat aaaaatggct aatcaggcaa agaaaaatga ttatagcttc
    40321 tttatgttca atgatataat ttattttgta gatgatgaat gtataagtta taagataggt
    40381 tttagagatt aaattgtaaa atttataaga cgtttattat tattaaaata ttatagataa
    40441 ggcgagtggc catagtacac ctttaaggtg tggagataga ataaaccttc tattatctta
    40501 taataataga aggtttattc tattgtaata taaatatcaa gatgtattaa taaatattaa
    40561 agataatcaa tttagattgt tttttaaatt gaatcattta tgttgtagtt atttcaatga
    40621 tgacatgtgt atgacaaata taagacactt ggaaatattg aaagacatat atatctttat
    40681 tgcttagaat cgaatatagg aggttgattt ttatggttga aagtattgga atttcaacaa
    40741 gtgttcctga gaggaacatt ttgtttggtg tttagccacc ataagagctt attttgatgt
    40801 ttgagtggtc actactttga gtgtgatagg attgaagagc tactacttga gggtagatga
    40861 tttactggaa tggtttatca tgtgaattaa attctgtagc ttctaactag ccttaagttt
    40921 aagggttacc tatttataaa aaatgataga taatgagatt taatctgtag tcaaagatgt
    40981 agtagaaaaa ataggatata aagatgtatc tgacaccttg aaaaacatat tgatgaaaaa
    41041 gttaaaaata ttaaggcagc ttatatagct gtcttttttg tatagaataa aaaagtttat
    41101 tataacagat agttattatt ttattagtgt gttaccaaga ataaattcct tttatctaac
    41161 atttattaca aataatatat atttttatct aatgaatgat tttatatttt agtgtaaatt
    41221 ggtatatttt accatttaca cttgatataa taaaaatata aactatttaa atagaattag
    41281 gggaattgta tggaaaagta tctttttaat caaaaactat taaaagaaaa atataatatg
    41341 gaaatagacc tagacttata tgactataaa caaagacgat taattttaga aaaatggaga
    41401 gatataattg ataataaatc tattgataaa ttaaatgaaa ttcaacttaa ggaaatattt
    41461 gtatcggata ttttaaacaa agttcttagg tataaaagtc ttacggacaa tataatggat
    41521 tataatataa aaccagaaga aaaaactaag attgatggaa caagagctga tattgtacta
    41581 ggctattttt ctaatgaaga aagtgactat agagtagcaa tagaattaaa aaaaccaaca
    41641 actaatttag atgcaaaaca actaagaaaa aacaatcata atacaccagt agaacaaggg
    41701 ttttcttact tgcctaaata tggaagaaat tgcacatggc ttattgtctc taacttcaag
    41761 gaaattagat tgtataatgc taatgatgct acagagtatg aatttttttc tattaaagat
    41821 atatatgaaa aagatgatgt atttaaaaaa tttttatatc ttttgtcatc taaatcttta
    41881 atgaccaaac atggaaaatc tagagttgag atgctttggg aagagaatat aaagcaagag
    41941 gaagccatag aaaaaggctt ttatgaccta tataaaaata ctagattaaa tttatttaat
    42001 gatatacttt taaataataa agatattttg gatgtaaaaa cttgtttaac aaagacacaa
    42061 aaaatattag atagagttat atttgtttgt tttgcagaac ataaaggatt aataccagag
    42121 aatatctttg aaacatgtat tcaagtaggg aaaaaaagtg tatctaggtt tggagtctgg
    42181 gaacaagtaa agggtctgtt tgaatctata gatttaggta atcaggaaaa gggcataaat
    42241 caatttaatg gaggtttatt tgcagaagat tatattttga ataatctaaa gataccaaat
    42301 aaatgtttcg agaatttata caagttatct ttatatgatt ttaatagtga tttaaatgaa
    42361 aatatattag ggcatatatt tgaaaaatct atatctgact tagaagaact aaaactagaa
    42421 ataaatcaag ttaatattaa gaaaaaagat agtaagagaa acaaagatgg gatattttat
    42481 actcccaaat atataacgaa acatattgtt aataacacca taagaagata tttagatgag
    42541 aagaaaaaag aattaggcga agataaactt ccagaactaa aagaagaaga ttatgaaaca
    42601 gttgtggttg gtaggaatat acagcataag cgtgtacaag ttgtagaata taaaactgat
    42661 aaaattcaaa aatatataaa cttttggaaa aattatagag acgttgtaaa aaatataaaa
    42721 attttagacc cagcttgtgg aagtggagct tttttgaatg aggctttttc tatgttaaaa
    42781 aaagaagctg aatcagtaaa cgaaatactt cgtgatttaa ccgatggtga gatatcattt
    42841 tttgacttag atgctaatat attaaaaaat aatttatatg gagttgattt gaatgaagaa
    42901 tctgtggaaa taactaaatt gtctttatgg cttaaaacag ctaacaagta tagtttatta
    42961 actagcttag ataataatat aaaatgtgga aattctatta ttgataacaa agaggttgat
    43021 tgtgctaaag cttttgattg gaatgttgaa tttgaagatg taatgatgtc aggagggttt
    43081 gatattataa ttggaaatcc cccatatgtt tcaactaaaa tgattccaga aaagcataga
    43141 gaatattatt ggaaaaaata taaagattta ctaattagcg aaatggattt gtatgagttg
    43201 tttttatatg agttttgtga aaataaatta aagcaagatg gatttttggg atttataaca
    43261 cctaatacgt actttacaaa taaaagcttt gaaaatttaa gaaaatattt acttaaaaat
    43321 gtatgtgttg atactatttt agactttcca tatagatttt ttccttttga ggatgtaaac
    43381 aaggaaaccg ctataattat aattaataaa aaattgccga atattaaaaa taatataaat
    43441 cttataagta taaataaaga aaatatgaaa aagattaaga ttttcaatag taatacatac
    43501 aactctgaaa ataaaattac tataaaaagt attataaatg atttggataa taaaattgtt
    43561 atacaaagca acccaataat attaaaaatg ctcaaatgta agcataaatt aggggattat
    43621 ttaaatttac ataaaggttg gatgagtgtc cctaataaaa caatttgtga tggaattata
    43681 tatgataaga aaatattaag tagtaatgat ataaaagata ataaccaatt aaatggaatt
    43741 ttaaataaat gtttggaagg taaggatata catagatact atattgataa agtagataaa
    43801 tttgtaaata ttgaaaacat ggatgacaaa actatgaggt ggcacaaatc acctaagata
    43861 ataacacaaa gaatagttgg tcaaaatcaa aataagataa ttgcaacagt agatattgaa
    43921 ggtactataa tattccctag tggaaatatc ataaatttaa ttaaagaaga taatttggaa
    43981 gatatatatt tttatatagg agttataaat tctagtttaa taaattactt ttataataaa
    44041 ttttatggag aatcaaatac caacttgaca gcagatgcag taaaaaatat accaatacca
    44101 aatttaaaaa atgttgataa atcaattgtt ataaataata gtaaaatact aataaataaa
    44161 tatggtaaat tatacttata cactaataaa tttttgaaaa atgtatttaa gatattgagc
    44221 atagataata atccatctaa taaattatat aatttttatt tattagattt tgatgaattt
    44281 tacaatgaac ttagcaaaaa aaagaagctt tattttaaga atattgatga gttagaggaa
    44341 tattttaata agtacaaaga tgctattaat agaatcatat acgatataaa tgtatgcgaa
    44401 aatacaatca atacttttgt atatgatttg tacggtataa ctgagctaga aagtaaatct
    44461 atagaagata tatgtaagac aacaaaagac actgtggtta caagtttagc ttattaataa
    44521 agatttggag gtcactttcc ttttgtagta taaattttcc tttagaattg atataattaa
    44581 tgtatcagaa tatagggggg atattatgtt taagaaaata ttattgattt taatgattag
    44641 tttgttagga tttggagtta ttggatgtag tgatagtaaa gaagatacaa atgaagtagt
    44701 aaaaaaagaa acagaagaaa agttagatga agaaagtaca tctgaagata tttataataa
    44761 aaaattgcaa tttttaaatg acactaaaaa tcaaagtgaa attataggag atgaaataag
    44821 attacttact gaaaaatata ataactatga aattgtgaaa agtgattgga aagaagactt
    44881 aataagtaaa aagaaaataa ttactgattt aaaaagtgta ttagaagaag aaaagtcaaa
    44941 tattttagac ggagtatctg atttccaaaa aacaatatta caaaataaat ataatgaaat
    45001 aatagagtat tatgattata tgttgaaagg aataagtcag aacttaaata tttaaactta
    45061 aatatttttt ataaagaaaa agtacagttt ctatatgaac tgtctttttt ttatacaaaa
    45121 aaggagttga gtaaatggtt gaagagttta aaattaaaac cagtattgag cttgatgaca
    45181 aagatgctag agaaaaaata gagaaattaa aaaatagtgg tcaagataaa cctattaaat
    45241 taaatttgaa aataggtgaa ttagataagt tatcacaaca agcagagcaa ttaaaaggga
    45301 tattcaataa agcctttaag attgataata ctgctttgag caacttaaag caaattgaat
    45361 ctactatgaa agaaataaat aaactaagta gaagaagtca agagagctta cttggtggtg
    45421 gctctggaaa cacaggaaat ataaataatg aacagcaaga tttaataaga caatataaag
    45481 aaatctcaaa tgttgtatct agacttcaaa atcagattag aacaggtcta ggagatagtt
    45541 caattgaaag aacaacagaa caaattgaaa gattaaaaag acaattagat tcagtgtatg
    45601 cacaaatgaa ttcatcatct caagctagaa tggatatgtt tgatgcttca agagcaacaa
    45661 gagatttagc tgatatgaat agaaatcttt caagaataga agatatggca acacaagcat
    45721 ctgctaggct taatggatta ggcgataata tagatacaga taaagtaaat agacttagga
    45781 atgagttaca agaattaaaa cagacagcta gtagaaatat agatttaaat cttgatgtag
    45841 gtaatatagt taatagaata caagagataa atcaagaagt tagaaatcta gaaagagttg
    45901 atagcttaag gtctaatttc agcagaatag aagattctat tagacaggca tttgggaatg
    45961 agagagttga agcttttaga cgttctttag agcaacttca aggttcggca ggaaatctaa
    46021 atggtgattt taacaatata tttgatagat taacaagaga aatgagagat gctagacaag
    46081 aagctgaaag attaaataat acagtttcaa gaggtggagg attttttaat gatttctatt
    46141 catctgtagc atcttattct attggagata tgttgggcga tgctttgact gatggaatta
    46201 ggtctatgaa agatgttata ttagagcttg atagctctat gactgacctt aaaaaggttg
    46261 cagaaccaac agatattgat agtacatctg agttagatag aataagagaa aaagcaatac
    46321 aaacagctaa agatgtagga atgagtgcat cacaagttca agaatcaata gcatcttctt
    46381 tacaagcagg aattggaggc atgcaagaaa gtattgctgc tgcaagacaa tcaatgatac
    46441 ttgccaatgt aggtgatatg gatgttgaag gtgcatcttc ggcagtaaac acaataatca
    46501 atggatttag aatagaacca cttaaagaaa tgcaagtaca agtcgggaat acaacaaaga
    46561 aaacaacaga attaactgct gcaatggata tgctaaattg tttggcgtgt tagatagaaa
    46621 tatctaatat tatgaggggg caaaatcggt gaagactgag atgttaccac cgaggtaaat
    46681 taaagaatta aaagacttta atcaccgtaa cgcataggaa atgaacctat gctattttta
    46741 tgtttaaaat agtatagaat ataattttcc cacgagtgtc ctccatctta acaagtaatc
    46801 ttgaagatga aaatatatgc tgaacttaca tgaataagaa atgtaagaac tacaagataa
    46861 aaagcttgta ggataacaat ttgaaactat gcagggaata attatgcaat tggaacagca
    46921 ggtgttgccg aagcgattaa ttttagtcgc cttatatagt aatatataat gataaactcc
    46981 tttaactgct ggaaactcct gttaggcttt tagtactaag tgtaataatc taaaagatag
    47041 ggacaatcag cagccaagac tcaatagagt aaggttcaac gactaggtta taaaccgtac
    47101 atatcaagct attggatatg gaaatgggga gcatccttat aggatgaaga tatagtctcg
    47161 tctgtatgga aacatatagc agttcataag agaacggatt aagtgtagcg aacttaattg
    47221 aagataaacg gaaacgtgga ggtagtgtac ttcatgagta tggtgtcagt ttaggtgaca
    47281 cagtgggtat gataacagca acaaatgaag cgatacaaaa tccagaaaaa gtaggtaatg
    47341 gtttaaaaag tgtcgcaata aatttagcag gtatgaaagt ttcagctgat gatggtacac
    47401 tttctttaaa taaaaccgca aaaggtttaa aggaaatagc tggaataact atttataaaa
    47461 ataaagatac tggtgaattg aagaatatgg ttcaactctt agatgagttg aaaggcaaat
    47521 ggggagaact cagagaggat gaacaaaaag gattagctga agcaatagca ggtaagcaac
    47581 aagcagctat attccaatcc ttaatgggta attatgagac ttttaaagaa ataagaagtg
    47641 aattttcaca agggttacaa tttggttcgg ctgaggctga aaacaaacaa tatttagata
    47701 gtcttgcagg gcgtttaaat gagttgaaaa caatatgggc agatatattc caaactgtat
    47761 ttaattcaaa tacaacatat ggatttttag atggtttaat atctgtatct aatggaataa
    47821 atagtgttat aaaaacatta gaaagattaa aattaacaac accagcatta ataggaagtt
    47881 ttatgacttt aaaaacgtta ttctctggta tgggaatgac aaatggtact agaaatgtgg
    47941 ctagacttat aaatccttta aatatgatag gaactcctat taaagctaca actacaatac
    48001 tacaatcatt tagacatgca gtaatggcag caaatgtagc tggtgctaat ggagcaaatg
    48061 taattactag agcaggaaca ggtttgggag cattaagaca aagtttatct aggacttcta
    48121 ttggtattgg aacattaaat atagcgacaa gtttgttaaa cggggctatg ataggtttgg
    48181 ctacttttgc tataactaaa ggtatacaat ggatagatga tactattcac aagtatgaaa
    48241 aattagcaga aaaacaaaaa gaagttattg gaactactac aagcgagata agctccttgc
    48301 aacaaaagaa aaagagttta gaaggtatat cagaagagta caataattta gctagtaaga
    48361 ccgaaaagac tgctgatgaa actgaaagat ttagcgaact taaacaacaa attgcagata
    48421 tagcaccaga attagtattg ggtgtagatg agaataatga ccctattcta aatatgagtg
    48481 gtaacttaga tgaggtcatt aataaattaa gaaaggctat agaagaaaaa aataaacttt
    48541 taaagtctca agaagatgaa cttgcaataa ctacatcaaa gactgcacca gatacaaaaa
    48601 aagaccttga taaagaaaag aaaaaacttg ataaagttct tgaagatgag cataatttat
    48661 ttaaaaatgc tttaagtaaa tctaatttta aagaacaaac agaagcatta aaaaaggctt
    48721 acaatcaaca agaaacagat tttgcagaac atcatcaaaa acttcttact gaatatgaaa
    48781 aatataatga agaagaagag gtaatgcaga aaagggcgat taatagatta actaattctg
    48841 atatatctaa aacatatgct aaacaatctg aacaaaagaa aagtaaaatg aatgagcttg
    48901 tagctaatat gaattggcat gactatagtg taggacaaca gaatagcatt ataagtgctt
    48961 ttgataaaat aagtgagtca attcctgttg aaaaattaga ccagtggaat aagaagataa
    49021 ctgatgctaa tataaattat caggcatccg gtgatatgaa tcaatatacc aaagaattac
    49081 aagggttggc gaatgaactt caaaagctaa gtggtggaag tataagtgct gatacttggc
    49141 ttattggatt acaacaaggt ttttctggat tagacttagc cagtatgaaa ttacatactt
    49201 tcttgaaaag ttatggttca tctttagctg aacttgaaaa caaagatagt tttgcaataa
    49261 agcttaaaaa ccaatttgat gcattaaatg atttttctca agatttagaa gttaatggta
    49321 aagtaaatat aaaactgctt gaagatatac aaagtggaga agctggtcaa gatttaccac
    49381 aacaactaaa agatataata aatggattca catttggaga agattcacaa atagaagctc
    49441 aggctcaatt agccctacaa gtaacaacta cgttgcaaaa cgaaggtcaa ttatctaatg
    49501 atgttgttaa acaattaaat gacttattta agggtaaatt acaattaaca gatgacattc
    49561 ttaaaaatgg actaaaaatc agtgacaagt tacctgcatt accaggaaat atggttcaag
    49621 cattaaatga gcaatttgca aatgctttta caggagacaa tgcccctgaa atcactccta
    49681 gtgtcaatgg agaaaaagct aaaaaagaat taaaagaatt agaaaaattc aaaaaagaca
    49741 cttttaaatc agataaaatt gtgactgaaa ttaataataa aggactagat ttcgcaaaaa
    49801 aagacttgag tgtattaaaa gaacagttgg atagatttaa aaatgaagat acaaagttgt
    49861 cttttactac agattgtgca gatgctttta aagatgtaaa ttctttagag gaagctagaa
    49921 aaaaaatatc tgctccaatg agtctaaaat atgatataga tgtagataaa aaaggattga
    49981 ctgaagcaaa aaaagtctat gatattttac ctgataatct caaaaaaaag atagaaacag
    50041 aagtaatagg tatagataaa ttagacacat tacaaaactt aatagataaa gctccaaata
    50101 aaaaagaaac tatatttgaa ataatcaata aaaatccaga taaactaaat gagatagatg
    50161 aaattcttaa taatgttcca aatgataaaa aggaagctgt tattgatttt atagtaaaca
    50221 atttagacca acttgaaaaa gctaaaaatg tacaagaatt tataaacaat ttacctccag
    50281 aaataaaaaa acaacttgga atagaagttg aaggaggaga aaatgcagag aaaactgtta
    50341 atacagttca aaatgcagat ggaactaaag ctgacctttt agtaaatgca gaagtaaatg
    50401 gagaatcaca agtagttgaa tgcatagaaa cattagataa gaatgggaat aaaacataca
    50461 ctcctaattt aaatcctcaa gttaataata gtgaaaaagt tgttcagtgc atgagaatat
    50521 tagatgaata tggaaatgaa tcttatattc caattgtaag tcctcaagtt accaatgaag
    50581 aaggacttaa cagtactaaa caaaaaatgg atgagttaga taataaaaca gtaactccaa
    50641 ctgtacaaat aaagacagaa ggagaaactg aagttgaaca ggcaaccaat tttatagaaa
    50701 atacaaatcc aactaaggtt attgagttat ccataaacaa ctctggtaaa gatgaaattg
    50761 acaatacaaa acaaaagtta gatgaactta ataatgaaaa agccactcct actattgaag
    50821 ctacaggtgc agaacaagca tctgaacagt taaatcaatt atcacaaaaa gcacaagaaa
    50881 ttgggcaagg taattatcat ataaatgtta gtacttcaac tgaacaaggg gctaagaata
    50941 tttcaggact tatagctaga gtaaaacaat tcttagcttt gaaagtatct acacttgtat
    51001 ttagaactga aactgcacaa gcagcaaaaa atgtatcagg tttgttagcc aaagtacaaa
    51061 gttatgttag ccgatatggt ggaaaaacta taaagactac atttagtgca ttaactgcaa
    51121 ctgctgcaaa gaacatatca gggcttatta ggaaaataga gtcatttaaa tcaaactatg
    51181 caggaaaaac attcactact acatttgtaa ctaataaagt aaccaatagt tctggtggtg
    51241 gaggtggagg aaatagttca gataagacca ataaaactga acgtacctct gttactaatg
    51301 gaactccaat tccagctaat ctatcccaac ctagaacatc agaaccagca ccaataagtg
    51361 acgaaactcc tgtaacaaaa ccatccttat tctcaagagc agtatcaaga gccacatcag
    51421 cttttaaagt aatcaaacct aaagttacaa taaacaatga cacaatagac tcatctgtaa
    51481 aatatagcat agaattattt aaagagttag aaaatgctat atcagcagta acaaatgaaa
    51541 tagctctatt agacaaaaaa atggaacatg ctacaggtga tgagaagatt aaatacttac
    51601 aggagcaaaa taaattattt gctcaacaaa aagatttaat aaaacaacaa caagatggat
    51661 ataaagctga aagtaacaga cttaaaaata gattaaaaga aaagaaaatg ggctttaagt
    51721 ttgatgatac tggaaatcta actaactatg aagaaaagtt aatatcaata gaaaaagaat
    51781 tagacaaatt aaattcaaag tctggtgaca aagaaaataa aaaagatgaa tccagaaaaa
    51841 aagagttgga agaaactaag aaagtccttg aagaatatat taaagttaca tttacagaac
    51901 tgcctaaatg tgagcaagaa tgggaagaat acaataataa aattaaagaa cacaatgagg
    51961 aattaaggaa agcacaagaa gaaatgtgga aacttaataa gaattccaca tggacttcta
    52021 tgtacaaaga tgtagagcaa gtaaataatg aaatagcaat gatagatgta ttacttaaaa
    52081 atgctacagg tgatgagcag atagagttgt tagaaaagaa aaaagagtta atggccaaga
    52141 aggctaaaga actatctgaa acaacagcat atcttcaaga aacacaaaaa gagctacaac
    52201 aaaagctaca aggctatgga tttacattta gagataatgg cgatataact aacttcattc
    52261 aacataaaaa tcaacttaaa aagaacatga ctgatgaaga atttaaaaga atggaagatg
    52321 cagcagaggg atatttggat ttattaataa ataaaatacc tgatgctaat aaggaaattg
    52381 ctgaatctaa gaaagaaatt gaagcattaa ataaagaaat tcaagatgct tataaagacc
    52441 aactcaaaga agctcaaagt ctacaagaga aaattagaga catgtataaa aaagaacttg
    52501 aagagagact taaagaaata gacaaggaaa ctaaagctaa aattgattct cttaaaaagc
    52561 aacaagatgc ttacaatgat tcaagaaaag aagccaaata taaagatgat tatgaagaac
    52621 aacaagatgt aataagtgat ttagaaaaac aaatagcaat agctgaaaga gatagttctt
    52681 taagtggtca gaagaaactt aaagatttac aaaaacaatt aaaagaagaa cagaagaaat
    52741 tacaggattt agtacaagac catgtagacg accaagtcaa tgatatgtat gataaggagt
    52801 ctgacagact acaagaagaa gcagataaat taaaagaaga gttagagaaa aaatactcag
    52861 atgaaaattt agttgattta attaatgaag caatcagttc tggtaaattt gtaggtcttg
    52921 atggagaagt tgagaaactt caagatgcta tcattgaata cataaacaaa tatgaagatg
    52981 gcatgttggc aatgggttct gttactaagc aagaatggct tgatacacta aaagaaggta
    53041 aagagacatt agaagatatt aatgacatat tagatgaatt agatttaagt aagtttgcta
    53101 tgcctaatta taatcctcct tcaaattctc gttcaagaag tgcatttcca acatcttcag
    53161 ttaattttaa ttcaccattc tttgttgttc aaggaaatgt aactaaggat actatgaaag
    53221 acttggaaaa atttggtaga gatttagaga atagagtata tagaaaaata gtagaaaata
    53281 ttaaatcata gattatttat atagacaaag gattttaagt agaaatccag atttctctaa
    53341 taaaatccag attttatttc aaaaaataat atgtatatgg tataatagta atataaatga
    53401 tataaattta tatcataaag acataaaaaa agagactaca actatttgtg ctagggtgtc
    53461 tcttcataaa taagcgaagt gttaattaga ggaagaatca cctgaattgc cgttcgggtg
    53521 attcttaatt ttttgcaacg ttttcttaaa ctcatctatt tctttaaaga gtctatttaa
    53581 attctgaacc aacttaatca aactaataat tatagttgta agaaatgtta ttatcgttaa
    53641 caaacaaatt agatatttca taatatcata tcacctcccc tcttgatttg acatgggaag
    53701 gcttatgtat atgaagattc accctaatag ttttttttat gtagtctcta aaaatattat
    53761 accataaatt accaatatgt taaatttaat attatattgt ctacaattgt aaaagaatat
    53821 tgtgttctaa gaagttattc tattaataat atagcttttt tatttttcaa tgaagataat
    53881 gacaacattg actattttga taatattgga gtataatagt aatataaatg atataaattt
    53941 atatcatagg gacataaaaa agagactaca aactatttgc tgtagggtgt agttcttaaa
    54001 gttaacaata aaaagaatag atttatgtat tactttcaga atcactagac ccgccagtct
    54061 ggtgattctt tagtttccta atagatgctt tcaagtttaa gattgcatct attagctttg
    54121 tcaaatgatt gattattctt gtaatcataa ttatcattat taaaaacaaa actaagtact
    54181 ctatagtctc accccctttc ttactgggga ttttaactaa agagccatca ccctaatagt
    54241 ctaaactgta gtctctaaaa atattatacc ataattttcc aatatgttaa atttaatatt
    54301 atattgacga caggagtaga ataaagatat aatacagata acagaaaatt taaaaatttt
    54361 acataagaat tactacttat ctatgccacc ttaaaaagtg gctatttttc tattctggta
    54421 tatatttaag ggtgttacaa atgataaata atatagaaga ttgtaagctt cttattgagg
    54481 cagaaataag aatgaaagat atagatgaaa aagaactaat atctcaaagg gatattctga
    54541 aagacctaaa tattaatgaa aaagaccttg aagatattga agtgaatttt gaataatgaa
    54601 atgatttata atatacctat tttaaatatg tattagttga tatcagtaat cgtctttatc
    54661 tagtgatttt ttatttatta actgtaaacg aatctgtttt acaaaaaacg tatctgtggt
    54721 ataataaaag taaggaattt aatctactta atacaaagag tgattgtttc cttaaagtta
    54781 attaaaaatc aatttatctt ttgaaactac tcttattggc gtttgagtgg ttttttgctt
    54841 tatcatatat gtaacaagct attaaacttg ttacaatatt tagattaata aaatatttta
    54901 gctcatctta attgatgggc ttttctaata caaagaaggt gataaaatat gcattttaat
    54961 gtgaatctta aacagataaa atctgattac acattaacca ttcacaagat gaacaaatca
    55021 tttttaggtc aaatcccaat caacttttta aattctataa agcgtgagct tggtggagta
    55081 gatgaaatac aactgaccat tccaaaatat attacagata gatttttatt taataaaata
    55141 ataaatccca tttttgaaga agtaaaagaa gaacgtctta tttgtcttaa taataaagaa
    55201 tattttgtag ttaagaatgt tgtgactaca gacgataaat taaaagtagt aacagctaaa
    55261 tctaaagaag ttaaactagg aaaaattgat gtgaatattg aggactatgg attacagatg
    55321 tttaccaaag atgaagaagc atctattata tctcttaatg attatttaaa acaagagaca
    55381 ggctggaaac ttggttatgt ggatgattca attgcttatg aaactgatag tgaaggtaat
    55441 aagagagaaa aagtaagatg gcaagagagt attaattcta attggttaga ttatttcaat
    55501 aatgaactaa aagaacaatt tgagtgtata gctgattttg acacttataa taatttagtt
    55561 aatttgtatc atatagacag ttttggagat aacattcagt tatatttatc tcatgataac
    55621 tacataaaat cacttgaaag aactacaaat agtgatgata tagtaactag actgaagctt
    55681 gaaggtagtg aagatatgga tataatagga gctacagtta caggatatga ttacattgag
    55741 aattattctt atttcttaga caataaagaa atgagtgaag aacttagtag agctataaag
    55801 aaataccagg aaatgaatga aataagagaa ccaatttgga gagaactaat agatacaaaa
    55861 cttaagaaac agagagaacg tgatagtaaa agtaatgaat ggttacatgt aatagagact
    55921 ataaaggcta aaaaggatat aaagaaaact tatgataatc cagaacataa agatgaagta
    55981 aattcagcta agttagcagt agaaataagt gaactagaag ataaaaaggt catattagat
    56041 gttcaaataa aacatttaga agaagagata gcaaagttag atgaaagtat aaaagatata
    56101 aatattcttt gtaagagaga aacctcgact gatgaggatg gatatttaat atttaatgag
    56161 gctctattgg atgagttaaa tgagtttctc tattatgaca cttatacaaa tgatgctttt
    56221 ttaaaagttg aagatttaat agcagaaggt aagagacaat taagtttaaa atgtattcca
    56281 accaaagagt ggactctgga tgttataaac ttcttagata gaataataga tattaatttt
    56341 agacaacatt ggaagggtga tttaagtctg ggagatatta tagtgttaca tagcaaagaa
    56401 tctaaagaag aagaattagt ctattttaca tcttttactc aaaattttaa aaatgggaaa
    56461 ttggatactt tagaattaac tttaagtaat aaaaaagtaa aagaagatga caaaaggact
    56521 atagctgact atttgactaa agctgaacac gcaacgagaa cattaaactc taagagacat
    56581 ttatttattc agcaacagaa gaaaagaatt aatctaccag atgaatatat tcctaagaaa
    56641 aatatacaaa aggagctgat gtaaattgat attagataat tcaccagcag attcatggat
    56701 tagaattact ggagtaattg ttacctacaa caatacactt tatcaagtag tagatacaga
    56761 gacaaataaa aaatatatat actgggatgc tgataatcca ggaacattaa aagtttctaa
    56821 tgtaagatta ccagagggaa acacacaatt tttagtagtt gtaaatgaca atggaaaaca
    56881 cacagaagtt cctataaatt cttctatttt tgatatttca tttgatggta attcaagaaa
    56941 aaatacagaa gaacagattt ggggattata tgagactgat gaaaagcata atgaaaagtt
    57001 tgtagttatt gaaaaagata tagatggaat acatcaaaca gttttagaag tacaagaaga
    57061 tgcatctcat ataaaagaaa atatgtctct tatagaccaa agagctgaaa atgtaaatat
    57121 attagtaaaa gaagttacta aaaattttgg tggttcacaa gaaaatataa cattaagaga
    57181 aaacataaat aaagctataa ttaagttaaa tgcagattta ggtacattta gttctaatat
    57241 gtctaattat tttaatgata atgaagttac agatgaagaa aaagaaaaga ttgatattga
    57301 acttaattta ttagatacag acaaagcaag tttatataca gagctacaaa aacttattga
    57361 tagaactact ggagtagact tagtagcaat aaacacttca aaaacagcat tggatgcagc
    57421 aagtaccaat ctaaactcta taattaattc agttatttca gatagtataa ttacaccttc
    57481 agacagaatt ttagctataa atgcaaatgc tcaatataac ttaaagataa atgaacttaa
    57541 aaatacagtc gataaaattt acataacagg tatgggtgga agtatatcag aggaattttc
    57601 acagataaat gctacagcta aagaaataaa attagaagta gcaaaagttg atggtgcaac
    57661 taaaacaaat gctgctgaaa ttaaattaac taaagatgat ataaccatga tggttacgag
    57721 gaataactct ggctcaattg taggaattaa acctgataaa attgaatttg gatttaatga
    57781 tatatcaaat tatgtagaga taagcaggag tggtctaaca gtaaatcaag gagctatagc
    57841 atgtgatata ttaactactc catctggaca tgaaccaata atcagattat ttggaagtag
    57901 caggtctgga tttgcaatag atgcaagaca atcagatggt tctagtcaag cctcagcaat
    57961 aagattaaaa tatgatagca ataattattt ttgggtagga tatgatactg ctgagattta
    58021 tgttgatgga gaagaacact ttattgttga aagagatgat acttttgtaa gatgtggtgg
    58081 agctactttt acatttacaa atggagatag tttaggtgta ggatattcat tttatccaga
    58141 gcgttctgta actgatttag gttgtgagcg ttataaatgg agatatttat atgctcgttc
    58201 tactctgagt gaatctgata aaaagtttaa agagaatata gtatacataa aagatattaa
    58261 gaatagaact cgttcaagta tcactccaac accattttta gattttataa gagatgattt
    58321 taaaccagca acatttgatt atatagcaga aaaagatagg acaattgcag atagtcaaat
    58381 agggtttata gctaatgatt ttaaagatag ttatgttgga aaaacatttc tatatgacta
    58441 tggagaagaa aatggattaa tgtttagccc atctggttat acaactgttg tagcaactgc
    58501 acttcaagaa gaaatacaaa aaagagaaga attagagatg ataattaatg aattaaacga
    58561 gaaaattaat aatttaggag gatattaata tggaagtaaa tttacaaaaa gcatatacag
    58621 tagcatttga agagataaaa agtttatata atgaactaat actttataaa gcactcaaca
    58681 tgcaacaaca agaagaaatt gagaacttga aaaaagaact agaagaacaa aataaagaac
    58741 aataggatgt gatactttga aaaattatga aataaagaat cataccatag aggtcgactt
    58801 tagtaattat agaataaaca aaagattgct agattatttt atttataatg aaaatgatgt
    58861 taaaacagct tatattgaag ctatattgaa aaataaagat gaaataatag atttatctga
    58921 atatgataga gttttagtta gcattacaaa aagtgatgga caaaaggtta atggtgaatg
    58981 tgaagttgta gatgcagaaa atggtattgt agagatagaa cttagccgac aagcacttgc
    59041 ttctgttggt ataaatacat ttcaactatc ccttgtgaaa gatggaactt tactcaatac
    59101 tacaaatctt tattatagag ttgaagaggg tatgattaat gatgatgata tcacctcaac
    59161 tgatgaatat ggagtattat tggtaataat agcccaagca gaagagatta taaaaaataa
    59221 taaagagttg actaaaagag ttgaacagct tgaaataact atacttggaa atgaagaagt
    59281 tagggataaa gcagagcaga ttaggattta taatgaagat ataagaaaca tacaagaaga
    59341 agaaagagag tttaatgagt taacacgtca aaatcaagag gcaaatcgtg aagaatccat
    59401 tcagaatatg caaattcaag ttgatgataa acttacagat tgccaactcc aattagatga
    59461 aatgatagat gctaagtcta aagaaataga taatatagtc gatgataaaa tgcttgatgt
    59521 tcaagttcag acagacaaga agtttcaaga cttagacact agagctaata atacttttga
    59581 tttgtatgat aagacatttg aagataaact tacagataac caagagcaaa ttgattacaa
    59641 acttgatgaa gtaaatcaag ctatatctaa tgtagaagat tgtattgatg aaagtactac
    59701 aaaattagat acaaagataa aagaagtaga tgacaaaata gttgaagtaa atactgctaa
    59761 aactgatatg acaacaactg ttagtaataa aataactgaa tttgaaaata ggtttgaaga
    59821 attagaaagt cttgatgcta gaggcgaatt aatacaagct agagaaagtg ttgatggaac
    59881 tgtaaaggat actttaaagg atagattaac atatgacttt gagaaagtta acgagaaaat
    59941 agcagaaatg acttctgctg caactaatgt agcttttagt aaatcttatg ttgaatcgga
    60001 ttgggttgct gatggagaat attttaaact tatagttaat cataatttag ttacagaaaa
    60061 tatatttgta gcaatattag atgaagcaac taagaaaagt atgactaatt cttatactac
    60121 agtagattct aatacgatag aaatatttaa tgaaagtaac atagatgtaa aagtaactgt
    60181 tgtaaatggt aatacaaata aagaagttat acaagctaca ataaatgata atataacaac
    60241 actagatagt acttactcta gtattaaaat tgatgcaaaa tttgatgaga gtctaactaa
    60301 gataaatgaa aataaaagta atatagctac taacttagag aaaataaatc taatacaaag
    60361 taaagttggt tcgagtgaat taagtacagt atctaaaaat atatcagatg cggtaaatga
    60421 attagatgct agtgttaaag ttcttgaatc tggtggaaat acaaacgagc aattgaaaat
    60481 attaaaagaa aattataata aaatgtctgt ggaaatactt aaaattctat ttgaattaga
    60541 attagataag gaagctacag cagatgaagc tgggtattgg tatgataccc tatatgattc
    60601 taaaaacata agtaatttag atggtttaaa gcttaataaa tttaagcaac aattagagtt
    60661 actttcaaat agtggaactg tattatttaa aaatgtaaca gttccttttt tatgcaacaa
    60721 aataagatat attcatgatt taggaagcaa ctatagtgaa actaaaacag aagaatctta
    60781 tcaaaaaggt gatactgaaa taaaaataaa caagtattcc tacgaagtga gataggggga
    60841 attatatgaa aaagaataaa ctattacaaa gaggttcttt atttggaaac aaagaattta
    60901 aaatagaaga gtttaataaa aattttgata cttttaatgt taaagatata tttacagata
    60961 tggattctgg ttctgtgttt ataattaagg atgatttaaa gttatatgca gcaggatata
    61021 atgtttttgg caatttagga cttggaaata aagtatcacc tataagatat ttttcaaaaa
    61081 tagatattga caatgttaag tatgtttcat cttctggaac tcattctctt ttacttaaaa
    61141 ataacggaga tgtgtattct actggcttaa acacagatgg ggagttaggt ttgggagata
    61201 atattgatag aaatactttt actaagataa atataagtaa tgtaaaacaa attgcttgtg
    61261 ggaatggcta ttctatgtta gttacaaatg acaacgagct ttatgtatgt ggtaataata
    61321 aatttggagg gataggctta ggaaatacat ctactgtaaa tacatttact aaaattgata
    61381 atttgagtgt taaagaaata tttgcaggag tcagttgttc atatatatta actttaaata
    61441 atgaattatt ttcaactggt ttaaacaatt atgggcagtt aggacttaat gacactacta
    61501 atagaaatat ttttactaaa gtaaatttag ataatgtaat aaagatttct actgctcaag
    61561 gtgctgtaaa ttttctttta gaaaatgggg atgtctatgg ttgtggagat aattcaagtg
    61621 ggcaagttgg tgttggtgga ggagctacag taacagtctt aacaaaacta tctatatcta
    61681 atgtaaaaaa tatagaaagt ggtagatatc ataaatttta tatagctaat aataatgata
    61741 tatatgtaac tggagccaac ccagatgggc gtttaggaga taaaataaat tgtgatagat
    61801 caacatatac tcctagaaaa tcttctatta gtattaaaaa tataagtaaa attaaatgtg
    61861 ctcatgctat aagctttata ttaactagca acaatgaatt gtatatgaca ggagataaca
    61921 attatagttt ttcttattta aaaagatatg ataaatttat atatggattt gaaaaatttg
    61981 aggactttga tattgaagaa tgtaatcata ttgagtctat tgataataga ttattaataa
    62041 ataaaaatga tgaaagagtt ttagatatag ggcttgaaaa taattttgtg aatatctctt
    62101 tagtgaaagc aaatgacacc tctacattta ttgttgtgaa tggtaatgaa ctatacgcag
    62161 caggatacaa cgcttatgga ggtttaggtt taggtcataa tcgtcattgt tatgagttta
    62221 ctagagtgcc attggaatta gaagaaggag ttactataaa agatatatat ttaaatctag
    62281 gctcatattt cacgtttata ttactaagtg ataatacatt atattcaaca ggatataatg
    62341 tatttggagt gttaggatta ggggataata ttaatagaaa tacttttact aaagtaaata
    62401 tttcttctgt tgacaaaatt tctgtaggag ataaccatgc gttattaaaa acaactacta
    62461 atgaattatt ttcaactggt ttaaacaatt atgggcagtt aggacttaat gacaatacta
    62521 atagaaatat ttttactaaa gtaagtactg taacttatgt aaatgaaatt attgcatatt
    62581 caaattcttc atattgcata gacaatagca gaatatctta tgcagcagga tataatgttt
    62641 ttggcgaatt aagtcttaat gatacctcaa gtaggagcgt ttttgttaag atgaaatatt
    62701 taagatataa aacagataca acagtatcag atgtatctaa cattgctgaa attattcctt
    62761 ttaataatgg atgtttaatt agaactacgt ctaataacta ctatgtttct gggagacata
    62821 attattatag cacaagtatt aaaaattctg taactgatga ttattattca aggtttggag
    62881 agtttgtagg aagtaaaaac tcaaatgcaa atgaagtcgc agttttaata gatgaaccta
    62941 aattatcaaa agttctggtt tctaactata atttatgttt attattagat gctagtgatg
    63001 gaggatataa agaaataaaa ttcacaggaa gaccttcgac ttttggagct tcatcccaag
    63061 acaagaattt aggtttaaga agtcttatat cgtcttctat gccttattat aatcattatc
    63121 ttggaacaga caatctttta tatacaacaa gtaaaacaag gatggagtct aaatttgaaa
    63181 taagaggtag aaatgcaggt gggcaaagag gagacagtag ttattattct aatagtcaaa
    63241 aatacacatt atcaaatgct ttttttgcat ataattcaca agtaatatat gctagtagat
    63301 taaggatagt aattaaagat tattttggga acatatattg ttctggagta aattctcatg
    63361 gctgttttgg cataaaaaaa ccttatgatg ttagacatga tggttttgta aatatatcaa
    63421 aacaattttc taaaaaatat atcatatcaa atataaaaga aattaaaagt gatagacaag
    63481 ctttatatat attattaaat aatagcgaag gatatgtctg tggtaataat gctggtaaca
    63541 agttagggac aattaaagct cggtctgaat ttataaaagt tcctatagat aatataaaag
    63601 aatttattcc atcgaatgat tgtttattta ttcttacaaa taataatcaa gtctattcaa
    63661 ttggaacaaa tgacttaggg caattaggtt taggagataa tattgatagg ggtactttta
    63721 ctaaggtgcc tattgataat gtaaaaaaag taataacatg ttacaaatct tcttacattc
    63781 taacctatga caatgaatta ttttcaactg gttcaaatgg ctatggtcaa ttaggattag
    63841 gggataatat taatagaaat acttttacta aagtaaatat ttctggaaca ataaaggata
    63901 tattttgtgg aaggtatgtt tttattatat tattggagaa tgataatata atttctttaa
    63961 tgggttgtgg aaatagaaat tacataagtt caaatacaaa ttcaaacagt ttaactaaaa
    64021 taaatattga aggattaaca gacccatcaa ctatatcaaa tttaatgttg gaagaaggca
    64081 aaactataat tacaatgaaa aatagaatat ttgtcacagg atataactca ttaggaggtt
    64141 taggtgttgg tacttcatat aataattcat caggatatat tgaaggatat aaggatttag
    64201 cgtttaatag taatataaaa gaggttgctc taggagaata cactattttt gttttacttg
    64261 aaaatggaga tttatattct ggaggaaatg ctgatgatgg tataggtttt aatgaatctg
    64321 gtactgtagt attaaaaaaa ttaacaagta atataaagca catatatgca aatggtaaaa
    64381 atgcttatta tatagataat gataatgcct tatatgtgtt tggtagtaga caattgggtc
    64441 aaatcaataa ttattctgat gttgtacaaa aaacacctgt tagaaattgc cttaatgtaa
    64501 aacaggtata tacacagcat aatggtctta tagttcaata tactaataat aaattagaag
    64561 gaaaaggtaa tgctgtagtt ggtcaagtag gtatttttaa tggacatgaa gaaaatcaga
    64621 ttgcaaacac ttctggtgat aatcctagtg atttaagttt ttctaatgaa atgtctatta
    64681 taagaaataa ttatggacta ttagtaaata agaagatatt tttacataat gatgatagta
    64741 ttaattatag aataccattt ggcacaaatg ctggaaatta ctcaacttca ttgccttttg
    64801 ataatataaa aaagatgtct ttatcatcaa ctcattcaat tttgatatta gaaaatgggg
    64861 atgtctatgg ttgtggttca aatcaatttg gggaacttgc tataaataaa tctgagctaa
    64921 caacaacttc tgaatttata aaaattaact taacaaatat aatagatatt gcttgtggtg
    64981 ataattttac ttacttctta aaaaatgatg gctcattgtt ttctattggt aaaaactcag
    65041 aatatcaact tggaataggg cataatgatg aggttaatga gttacaagaa gtattaacta
    65101 tttctaatat aagggagata tatgcttata gtaattatat attggctata actacagaag
    65161 gtcaattata cgtacaagga tataatataa atgggatttt aggactgaat gagaatacaa
    65221 aaaatacaat tattaaatta tttactaaag tattagaaaa tgtaaaatat ataaaatctt
    65281 atgatgataa acatatattt gttataaaaa atgataagac tttgtatgtt acagggataa
    65341 ataaggaaac atataaaatt aaagatgtag agattggttc tatgttatat actttctcac
    65401 aaatatatat tccaagagat gttaatgata tagtggatgc tttaataaaa gatgaaacat
    65461 tatatataat ctcaaaagta gattcagaga aaacttgttt ggaaataaag aataagtcat
    65521 actcatctat tgaaatagat ttgcaaaatc caaataatga attgacaaaa atagagatgt
    65581 ttataaataa tattagttca agtataatag aagacttatc tacaggaaca gtcacgtttg
    65641 agattaatcc agagaattta gttcttggag aaaataagat tgtatttaaa gcacattctg
    65701 acattggaaa taatttatat ataaatgttt atatttataa aaaagaaaca ggagcaacta
    65761 tagtaaaaga ttcaactgta ttaatcgatg ggaatactta taatgtatct agtatagttg
    65821 ataattcaca agatgtagta cttacactca ataaaggtct gttagaagat ttaaattcta
    65881 acaatccaat ttatcattta gtaaataaat taaaagtaca attaaagata aatgaatcag
    65941 atacatttaa agatatggtt aaagtagaga caagaaaaac tgagaatgga tataaggaga
    66001 tatatgagtt aaaagatatg aatatacaat ctgcacaacc taaagtaata gtagaagaag
    66061 gaaacactaa tacaactata aaaaaaccat ctatgttatt caatttagat gttgaaacac
    66121 tttaagaggt gattaaatga taaaaataga taaagaaaaa attgagaagt caagacaaag
    66181 aaaagaatta gatgatttag attcaagtca aaaaacgcaa gataatgaca taacagattt
    66241 aatgttagcg actgctgaaa tatgcgaaat ggtattaagt agtcaacaga catctactat
    66301 gtcattaaaa aatataaaat taaatgaagg aggaagtagt atggcagcaa tttatgtagg
    66361 attgatagag agaggtttaa aaacaattga ccaagtacct gttaaatatc gagaagaagt
    66421 aagaaaaatg tgtgaagcac tagagatttc attatcatag aactgtaaga gttctttttt
    66481 ttatgttcaa aatagagagt tactaatgta gctctctaaa taaaaaagaa ggtgataaat
    66541 tgttaaatga agatgtagta aaaaaattaa aaaatgtacc taataacact aatacagaaa
    66601 tagaaaaagt taatacaaat atagaaactg ctaaaacaga gttgaatact aaaattgacc
    66661 aacttatcgc aggtggttca aatgtggcat ctactcaaac aataacaatt gatgattggg
    66721 tggatgatac agaaaatgga tttaaagcaa ctgtaacaca tggtttgtta acacagagaa
    66781 tagttgtaaa tattatagat gctactacaa aagaaaatgt agttacaaat tttaaaatta
    66841 tagatgataa ttctatagaa attagaagtg aaacaaggtc agaattaaac gtttatgtga
    66901 taaatggaaa tgcagaaact cattttatta atgcaactgt agatgataac agagtatctg
    66961 aaatgactac ttattcgtct aagaaaatcg aagatagatt tgttaatcta gaagaaaagg
    67021 taaatggtgg tttatctaat attgcaacta gtgtaaatga gttaataact tattgttaga
    67081 gaggagagtg agaaaatgca gactgaatgg aattttggtt ataatggttc gccacaaagt
    67141 gttatattga aacctggcaa atataaattt gaatgctggg gttcttctgg aggtatcaac
    67201 aattcttctt ggcatactga tgctaaaggc ggatattcta aaggtgaaat tacattaaaa
    67261 aaacaaacta cattatatgt ttacgtcggc gaaagtggtt ttgct
//
LOCUS       DAEHWM010000006        65180 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.006, whole genome shotgun sequence.
ACCESSION   DAEHWM010000006 DAEHWM010000000
VERSION     DAEHWM010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 65180)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 65180)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..65180
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.006"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(183..2249)
                     /locus_tag="KNP36_000450"
     CDS             complement(183..2249)
                     /locus_tag="KNP36_000450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBF0872345.1"
                     /translation="MVELIITTNIDIRKLNENQLEAVEHIDGPCMILAGPGSGKTRVI
                     TYRIANMVVNKNIAPTRILAISFTKASSIEMKNRALNLSDDIRLNKVTYGTFHSVFFK
                     ILRYFERYNLDSIFDEKSKRMTIKAILKSLNIENADDDENIGQVINEISYVKNELMDK
                     NEFNSEVLTKDEFLKVYNLYEEQKSKVNKIDFDDMLIRTYYLLLNNKSALEMVRNVYK
                     YILIDEFQDINKVQFEVLKLICSPLNNIFAVGDEDQSIYGFRGARPDFLLEFEQYFNN
                     TKKIILDINYRSKSEIVHTANRLIDKNKNRYEKIIKCSQGDGGSVTYISPHDSEEEAL
                     YIAREIIDEIQKDYVEYSDFAVIYRTNIQSRALVDVFMDMRIPFVVKDSVITIYDHWA
                     SQDILAYLRIGINPKSNKDWLRIINKPFRYISKDSINMVKDEKDFITALINKCNLHPK
                     QVKTINDLEIDLSYLNTLNPKNAISYIRTSLDYDRYVLDYCSNRKIKTNGLVEILNEL
                     ESSATNFNTVTEFLEHIDRVKTELTENNKNKQTEGVIFTTMHSAKGLEFRNVYIIGVN
                     EGTIPHEKSYDICKEEKKEEQLEEERRLMYVAITRAEEKLCISSTLNKYGKKVDKSLF
                     INDIKSPTKKEIDSIGVGDKVYHKKFHEGEIIKKDGIMFTIKFKDRERILDLKTCLLK
                     NIIYTI"
     gene            complement(2326..5355)
                     /locus_tag="KNP36_000451"
     CDS             complement(2326..5355)
                     /locus_tag="KNP36_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0872346.1"
                     /translation="MENNLRKNNSIMKKMIFPLIIVMLIQTSLFCATILWGGTIKKLN
                     DNSFDILNERVINRKNYIQNEMLQRWSNTSETEATINSSVKKVLNEKNALIEDVGNNE
                     EINKDIIKSISNDLIYLLRKNSVTGAFIILSDKNINDKSIDSKGEISRTGLYIRDLDP
                     KFNPNDNSDLLIERGSSDIARSFGISMDSYWEPKFSFKSENEQDGDDFFYKPFRAAID
                     NPNVSSSNLGYWGSKFLLTNAGDRLMTYTVPLIYEDGTVYGVLGIDLSVNYLRELLPY
                     SEINGNKKGNYILGVDRNNDMAFENVISNGYSLKEKFWDGLHSNLEQKESYKNIYKIK
                     NKDNECGNGNIYASVQYLDLYNSNTPFENERWALLGIIEEKSLLSFSKRVEKLVIISI
                     AISLLIGLIGIYIASRLFTKPIVLLANKVRNSNPSKPVNLDKINISEIDELSSAIELL
                     SANVADSSSKLSQIIEMVDMPIGAFELYKNAENVFCTKEFFSVFTTEIKFEEYGYMEK
                     NKFLKKLRGLDKYLQESYETENTYIYKFESKDKKLKWIRMNIFEDELKVLGVVVDVTK
                     EFIEKRKIEYERDFDILTNLLNRRAFHSQIQEKFKNKDELKIAAFIMWDLDNLKYIND
                     TYGHDAGDEYIRCAADILKKFISWNGIVSRLSGDEFYVFIYGYESKDSIRDIINSVKK
                     QMNNTLLKLHDGTEFKIRASAGISWYPDDSTNYDELMRYADFAMYQIKNTIKGEVSEF
                     DINIYNKDSFLLSNREELNKLIDGQLVEYAFQPIVDCKGKVFAYEALMRPKIKTFSSP
                     IDVIRLARSQSKLYQIERITWFKALKSFKKYKEKFGDCKLFLNSIPNNNLSKVDFEEI
                     EDLYGEYLNRVVLEITENDKINEDFIEKKKAYIDHWNIEIALDDFGTGYNGDAVLLYI
                     MPDYVKIDMSIVRGIDKDENRQKILKNLISYSNERNIKVIAEGVETKGEMETLINLGV
                     DYMQGYYISKPSFIPEDISDKIKKELKICHENRNDVV"
     gene            complement(5408..6868)
                     /locus_tag="KNP36_000452"
     CDS             complement(5408..6868)
                     /locus_tag="KNP36_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HBF0872347.1"
                     /translation="MNRCKFAKLIITSMIVLLLTGCSLKKEDNYKLDPENPTSIQIWH
                     YYNGQQKMAFDKLVKEFNDTVGAEKGIIVEAFSQGNVVDLSEKVLDSANKKVGSEDVP
                     NIFAAYSDTAYEMDKLGLLVDMDKYISKEELNEYIDEYVEEGRINSKDEFKLFPIAKS
                     TEILMLNKTDWDKFAKATNSNINDIKTIEGLVETSKKYYEWTDSLTKEPNDGKAFFGR
                     DALANYIIIGSKQLGVEIFSVKDGKVTLNIDEKVMKKLWDNFYVPYINGYFASYGKFR
                     SDDAKTGDILALVGSSSGAAYFPDRVMLNDNESYNIETSVFQAPRFKGEGKYAVQQGA
                     GMAVTKSTKEEEYASVEFLKWFTDKEPNIKFSIASGYLPVKKKTNDLDVIKEVMKKDN
                     LSLSDKVEGSIASSIEQINSCNLYTNKAFDGGTKARQILEYSMLDKAKEDSNKINELV
                     KSGTSKKDAVAQFNNDKNFKTWFESFKAELENAIKK"
     gene            complement(6960..7334)
                     /locus_tag="KNP36_000453"
     CDS             complement(6960..7334)
                     /locus_tag="KNP36_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872348.1"
                     /translation="MGNKNKNTKYKDKTRERYNKKVENLNKEKLNKINKQSKKVDKID
                     DIINKSSIVLCVLLVVFSLLYLFKLVQLNIIMILLVITVAIQQGLVSFGAFRNKNYVK
                     ALFSIFVIVCFLIAFKYVVNPV"
     gene            complement(7510..8250)
                     /locus_tag="KNP36_000454"
     CDS             complement(7510..8250)
                     /locus_tag="KNP36_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBF0872349.1"
                     /translation="MLYDEDEKEENNERWLLTYSDLITLLMIFFVIMYSMSNVDAEKY
                     KQLSQSLNSAFGGSSGVIEGGNSKIEPVVEPGSNDLDTLQNAKFKKIGEEIQKYLNEN
                     GMANSVSLRVQDRGLVISLKDTILFDTGKAIVKDNSRDKIIQIGKMLNEMNSYMRVEG
                     HTDNMSIKNSEFKSNWDLSVMRATNVVQLLIDNAGIAPDKLSAVGYGEFRPIAENSSE
                     EGRSKNRRVDIVLVDSKYDNVENVSKDK"
     gene            complement(8271..9059)
                     /locus_tag="KNP36_000455"
     CDS             complement(8271..9059)
                     /locus_tag="KNP36_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar motor protein"
                     /protein_id="HBF0872350.1"
                     /translation="MTTLIFFIVGIASLVVAFVIDGGHVGALFVFSSALVVFGGTIGA
                     VGASTPFPVFKKSIKIMLLAFKNKKPNNIENIIYFKEIATKARKEGLLSIDKEISEND
                     ELDPFIRKGLELMVDGVDAVTIRNILESQIQITSKRHKEGIAIFDSAGGYAPTLGIIG
                     TVMGLVHILGNLSSNPDALGPQISVAFLATLYGVGSANLIWLPIASKLKAINQQEVSE
                     RLLVIEAILSILEGDNSNLMTEKLKIFLNSKELIELEEIGGRAE"
     gene            complement(9147..9237)
                     /locus_tag="KNP36_000456"
     tRNA            complement(9147..9237)
                     /locus_tag="KNP36_000456"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(9201..9203),aa:Ser,seq:gct)
     gene            9496..10260
                     /locus_tag="KNP36_000457"
     CDS             9496..10260
                     /locus_tag="KNP36_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBF0872351.1"
                     /translation="MLPQERYEKILSILKSDNIIKINDIVQMFDISIETARRDLAHME
                     SIGLLKRVYGGAIPVIASSVELNYVKRKKINSNDKKQIAIKCSEFINTNDTIFMDTGT
                     TVLEVSKNLKDKKNLTVITNSILVANELMNTNIKVYVLGGYLRETEGSFSGPLTLSAI
                     EQFNVDKAILGAGGITLENGISDYHLEEALVRKKMIERSRKSIVVVEPPKFGINSFAS
                     VAPIEHIDTIITSASIDHNIIIEFSQKGIPLVIADN"
     gene            complement(10541..11656)
                     /locus_tag="KNP36_000458"
     CDS             complement(10541..11656)
                     /locus_tag="KNP36_000458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization protein EutH"
                     /protein_id="HBF0872352.1"
                     /translation="MPFDKIILYIMAVGVLLGALDRIIGNKFGLGEQFEEGFNSMGPL
                     ALGMVGIVCLAPVISDVLGPIIIPIFNLCGADPSMFATILANDMGGYPLAMELAHNKE
                     AGMLAGLVVSSMLGCTLVFSIPVGLGLIEYEDRPFFAKGLLIGLITIPFGGIIGGLIA
                     GFNLSMVIINMIPVIILAVILAVGLKFNSTLMINGSLIFGKFISILITIGLGAAAFQE
                     ITGIVLIKGMTPIREGIQVIGSIAIVLLGTFPILHLLVKVLNKPLTIVGGKLGMDATS
                     AAGLVFTLANSIPVYKMMKDMSPKGKVVNTAWLVCATAALGDHLGFTAGVVPEMITPV
                     VIGKLVGGVLAIALAILMTKDLTLEEEQSIKMKKDAV"
     gene            complement(11697..13223)
                     /gene="glpK"
                     /locus_tag="KNP36_000459"
     CDS             complement(11697..13223)
                     /gene="glpK"
                     /locus_tag="KNP36_000459"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HBF0872353.1"
                     /translation="MKYVLAIDQGTTGTRAVLINEKSEFVFSDYMEHTQIYPQSGYVE
                     HDPIEIWNNTKTVSNNVLQQAFENGINESDIKGIGIDNQGETVMLWDKNTGKPLYNAI
                     VWQCRRTYDYVENLKNIPGLENKIIDKTGLIIDPYFSGTKIKWVIDNVKGVKEKIKNG
                     EVLAGTLDSWLIWKMTGGKSFLTDVSTAARTMLFNIRDMDWDRELLDIIGVPRSILAD
                     IMPTSGDFGTTDKEAFCGVSIKITASMVDQPAALFGNGCFEPGMVKNTYGTGCFLYMN
                     IGEELNIAGNGILTTVAWKIGDKVTYAYDGGVYIAGAAIQWLRDGIGVIKNYSETDDM
                     ANSISSTGGVYFVPAFAGIAAPYWDQYARGTMVGITGSTKKEHIVRATLESVALQVKD
                     VVDSMNLASGKKIKMLRVDGGITKNNFTMQFQSDILGIPIEIAENPETTVLGVGYMAG
                     LSCGVWNSIDEIRSEFTISKKYIPNMTTQKREEILLGWNQAVKRAMNWENDTKKVCAN
                     "
     gene            13516..14613
                     /locus_tag="KNP36_000460"
     CDS             13516..14613
                     /locus_tag="KNP36_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBF0872354.1"
                     /translation="MKKTYLFSPGPVMVTDKVRNSLLHYDICHRGNEFMDLFKDTQQK
                     INKLYNATSNYYSLIVSGSGTSVNECVLSSIFDKEDAVLLVSNGVFGERLEEILSTYN
                     VKTYKPNFEWAEYPDLDILEKYIIENSDIKVIAMVFHETSSGMINPVPELGKLAKKYN
                     KIFFVDAISASAGEYIDVEEFNIDIITGVGGKALGAFPGSAYLCAKESILQNIKENQC
                     KNVYLNLYKHYKVAKSSSQTPNTPNVTLIFALNEALTEFLEDDSKIERYKECSAILRY
                     GMEELGLTFLLPDKYMSNTVTSVFLPKEINVNEFILGLERESGYVVYPGKGKFLDANI
                     FQVANMGEIYPEDCYKFLDILKSKLEIKKVI"
     gene            complement(15104..15616)
                     /locus_tag="KNP36_000461"
     CDS             complement(15104..15616)
                     /locus_tag="KNP36_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872355.1"
                     /translation="MKVKKFKSGIVMALTVMAIGASLTNVSAMELNKSKEFETKYNEM
                     KRDFQEEYGKEDKFNITLDDEFTKEEVNGAKGIIKTTNKMNNEVVVLNYFDEMKSGIE
                     FELKPKAEKNAILRDEFQQGYGKEDKFKVVLDDEFTKEEVNGAKGIIKTTDKETGEVI
                     VYNYFDELEK"
     gene            16169..17050
                     /locus_tag="KNP36_000462"
     CDS             16169..17050
                     /locus_tag="KNP36_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HBF0872356.1"
                     /translation="MKKRLIIMILSVVLVLSSILTIFAYSNIKYNNNKLIYSNMIDKK
                     TQNSVKEILKENKINEKDIDTFIKSVNNYNKLQVKILQNNINISKSGYSSINAKQVPY
                     NLEKLQDNWVKKFPDYMDVNCRITAFRLFKDFINSNKKFTGDSIDLNVDLDTIMNNKD
                     AKFSTKDVEKFINFFSAIPAKDTDDTIKIAEQIKNEWKKRKISFKNNKNISIINGFLR
                     YPETKNVFIGHTGICIKTKNGILFLEKYGVTSPYQVTKFKNKEDVKNYMFNRLKMSEG
                     EIELPDPIIMENDKLMK"
     gene            complement(17363..18142)
                     /gene="hisJ"
                     /locus_tag="KNP36_000463"
     CDS             complement(17363..18142)
                     /gene="hisJ"
                     /locus_tag="KNP36_000463"
                     /EC_number="3.1.3.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ"
                     /protein_id="HBF0872357.1"
                     /translation="MKDGHIHSPYCPHGSKDDFEKYVQRAMDVGITEMTFTEHFPYAN
                     GFRDPAPENDSCMSIEDLPKYFNDVKKLKEKYEGKIKINVGSEVDFIEGYEEGIKENL
                     NKYGKELEDSLLSVHIIKIDDDYYCVDYSVEEFQNLIDKLGSIEAVYNKYYETLIKAV
                     NSDLGIHKPKRIGHLNLVRKFNQVFPYDYKGNKILEELIKLIKEKGYELDYNVSGNRK
                     EYCKEPYIDGYLLDLVKKYDIPLVLGSDSHCAEEINKYDII"
     gene            complement(18688..19038)
                     /locus_tag="KNP36_000464"
     CDS             complement(18688..19038)
                     /locus_tag="KNP36_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc transporter"
                     /protein_id="HBF0872358.1"
                     /translation="MIFDKEIVRYHHGHHDHDHCHEHTHGDICHEHPHDHAHDHDHEH
                     SHEESSESKDEKTLKILLVHWINHNETHEEGFREWVEKARAIGKEETAKSIEKAIEYM
                     EEANKMLLEAKKHM"
     gene            complement(19054..19470)
                     /locus_tag="KNP36_000465"
     CDS             complement(19054..19470)
                     /locus_tag="KNP36_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3842 family protein"
                     /protein_id="HBF0872359.1"
                     /translation="MIIAVIDGMGGGIGAQIVSSLREELPTYVEIYALGTNSIATSSM
                     MKAHANKGATGENAIVVSAKKANIIVAPISVIIPNSMMGEVTCNISEAIADSEALKIL
                     LPIMPENVELVGLEGKPLALLVKDSVNLIKKEFNIK"
     gene            complement(19489..19680)
                     /locus_tag="KNP36_000466"
     CDS             complement(19489..19680)
                     /locus_tag="KNP36_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CooT family nickel-binding protein"
                     /protein_id="HBF0872360.1"
                     /translation="MCESSAFICKSNNELEKVMENVVNIDPCDGKIYLTDLLGEQKII
                     DGIIKEIRLMDHKIIIQEN"
     gene            complement(19831..20646)
                     /locus_tag="KNP36_000467"
     CDS             complement(19831..20646)
                     /locus_tag="KNP36_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase family protein"
                     /protein_id="HBF0872361.1"
                     /translation="MNQWRVIHNKSYEGAMNMAIDEAIFTAYKKGHNKPTLRFYTWEP
                     ACLSIGYFQKLEDEIDLDKCRCMNIDYTRRITGGRAVLHDNELTYSIIIGEDNPLIDK
                     SINLSYRYISEGLVKGLNLSGIETDNLNRGERISRENLSAACFNAHASYEVTINNKKV
                     IGSAQSRKDGVLLQHGSIILDFDVEKLFKLIKTKTPELKERAMKFTAKKASGIENEIG
                     RKIDIDILQKNIVKGLAEQFNVEFVEGDLTDYEKQLVKELYEKYKNEEYNKKR"
     gene            complement(20693..21631)
                     /locus_tag="KNP36_000468"
     CDS             complement(20693..21631)
                     /locus_tag="KNP36_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0872362.1"
                     /translation="MIRLSVGTAIELGILNKKSDIPPTTAYIMIGEKCINKCSFCSQS
                     IESSTRKDKLSRVIWPEFSKEEILDALKAYKGKNIKRICIQSMASEEAHNSVLDFINY
                     ISGKIDMPISLSAKLENDEQIKKFFSAGVDKIGIAIDAANKELYEKIKGNNYDEKLKF
                     ITEMSKSYPNKISTHIIVGMGESHEDIYNLYTYLKENDVTISLFAFTPVRGTKMEKIN
                     QPSIESYRRVQLMSYMINKGYPKEYFKFKNGYLNSIKLDNDILKDINKGYPFEIRGCK
                     DCNRPYYNERPGSTIYNYSRPLNQSEIDLAIREINL"
     gene            complement(21628..22500)
                     /locus_tag="KNP36_000469"
     CDS             complement(21628..22500)
                     /locus_tag="KNP36_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0872363.1"
                     /translation="MNKNLSEKMKIAFDIKLKNFGNKIEFAYPNQTLALSTTSNQCSL
                     KCAHCNGHYLNNMVPIEEYEEKVQSRNITSFLLSGGCSYEGDVPINTHINTIKNLKEQ
                     GYRLNAHLGLMDKDSIVELCKYLDIVSFDLVFDDETIREVYKMKKSKEDYIEVYNTIQ
                     EHTEVAPHICIGLKGGQIKGEYEIIEYLQKNPPNKLTFIVLIPTKGTEYENVEPPELE
                     GVADILCEARINLPDTEINLGCMRPRGVYRKELDQLSIMCGVNRIVLPSRSAKNKAIE
                     MNMTINECKECCVL"
     gene            complement(22525..24453)
                     /locus_tag="KNP36_000470"
     CDS             complement(22525..24453)
                     /locus_tag="KNP36_000470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4445 domain-containing protein"
                     /protein_id="HBF0872364.1"
                     /translation="MIKVSFTPNNKEVYCNEGDILLEVARNADIFIDAPCNGNVSCGK
                     CKVKLLNGKVDTEKTRHITDDEWEQGYILACCTKVISDIEIEVPSKVSSSMHGMKIEG
                     SNKKEDREIFERAKKIIEEHNLQFKTNIKKKYIEMEEPNLDDNISDVDRLERYVRNNL
                     GYNEIDFRLDILRKMPTVFRKSDFKVTITYVQKQKKLTIINIEQGNKENSLYGVAIDI
                     GTTSVVVCLVDLYSKEVVDKASSGNAQIKYGADVINRIIYSTKKNGLETLHKAIVEET
                     INPLLKTIYERNGIDKEDVVTLVAAGNTTMTSLFLGVYTDFLRQEPYIPPFLKSPKLM
                     GENVGLFVNDSAYVYLAPSVASYVGGDITAGVLSAGIWSSEENVLFIDLGTNGEIVFG
                     NKDYMMSCACSAGPAFEGGGISCGMRASAGAIEKVIIDKDTLEPTLKIIDECAPVGIC
                     GSGIIDLICQMITKGVIDRRGKIYRDLDNKRVRFNEHEIGEYVLAFKEEFDLENDIVV
                     NEVDIDNFIRAKGAIYSGAYTLVDSLGMDFSILDRVYIAGGIGNNLDIENSIIIGLLP
                     DIDREKFTYIGNSSLVGSYLALISKDAKNKLEEIGNQITYVELSVYPSYMDEFISACF
                     LPHTNIEQFPTAKKLLEE"
     gene            complement(24565..24942)
                     /gene="gcvH"
                     /locus_tag="KNP36_000471"
     CDS             complement(24565..24942)
                     /gene="gcvH"
                     /locus_tag="KNP36_000471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="HBF0872365.1"
                     /translation="MKLLPELKYSKDHEWVKVIDGDVVYIGITDYAQDQLGEILFVET
                     PEVEDTVTKGVDFGVVESSKVASDLISPVNGEVLEVNEKLEDEPECINEDPYENWILK
                     VKLADVAELDTLLSDKEYEAGLE"
     gene            complement(25029..27155)
                     /gene="cdhC"
                     /locus_tag="KNP36_000472"
     CDS             complement(25029..27155)
                     /gene="cdhC"
                     /locus_tag="KNP36_000472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CO dehydrogenase/CO-methylating acetyl-CoA
                     synthase complex subunit beta"
                     /protein_id="HBF0872366.1"
                     /translation="MNLYNIIFTGSEQALGAAQAMLAEAIEKNGKEHKVAFPDTAYSL
                     PCIYAATGQKMNTLGDLEGALEVVKSLINRTHLLEHAFNAGLATALAAEVIEALKYST
                     MDAPYSEPCAGHITDPIIRSLGVPLVTGDIPGVAVVLGECPDAESAAKVIKDYQSKGL
                     LTFLVGKVIDQAIEAGVKMGLELRVIPLGYDVTSVIHVVSVAVRAALIFGGLTPGDLN
                     GLLEYTANRVPAFVNAFGPLSELVVSAGAGAIALGFPVITDQTVLEVPMNLLTQKDYD
                     KIVATSLEARGIKIKVTEIPIPVSFAAAFEGERIRKSDMFAEFGGNRTEAWELVVKKE
                     ATEVEDHKIEIIGPNIDEVDADGVLRLPLAVIVKIAGKNMQEDFEPVLERRFHYFLNY
                     IEGVMHVGQRDMAWVRISKDAFDKGFRLEHIGEVLYAKMLDEFESVVDKCEITIITDA
                     EKVSELKGEAIAKYNARDERLASLVDESVDTFYSCNLCQSFAPAHVCVVTPERLGLCG
                     AVSWLDAKATKELDPTGPCQPIEKGECLDDRTGVWNSVNETVNQISQGAVESVTLYSI
                     LEDPMTSCGCFECICGIMPEANGFVVVNREFASVTPVGMTFGELASMTGGGVQTPGFM
                     GHGRHFISSKKFAYAEGGPERIVWMPKELKDYVADKLNATVKEMTGIENFCDMVCDET
                     IADDSEGVLAFLEEKGHPALAMESVM"
     gene            complement(27212..28018)
                     /locus_tag="KNP36_000473"
     CDS             complement(27212..28018)
                     /locus_tag="KNP36_000473"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HBF0872367.1"
                     /translation="MEKFMIIGERIHCISPSIRKALAERDPAPILKRAKEQLEAGAHY
                     IDFNIGPAERDGEEIMTWGIKLLQSEFNNVPIALDTANKKAIEAGLKVYDRTNAKPII
                     NSADAGSRFDLIDIAAEYEAMVIGLCAKEGIPRDNDERMAYCQEILEKGLMLGMEPTD
                     ILFDPLCLVIKGMQEKQVEVLEAIKMMTEMGLLTTGGLSNVSNGCPKHVRPVLDSAFL
                     AMAMANGFSSAIMNPCDPELMKTVKSCDIINGASLYADSFLELNEGGFAF"
     gene            complement(28068..29435)
                     /locus_tag="KNP36_000474"
     CDS             complement(28068..29435)
                     /locus_tag="KNP36_000474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA decarbonylase/synthase complex
                     subunit gamma"
                     /protein_id="HBF0872368.1"
                     /translation="MALKALDIFKLTPKKNCKDCGFPTCMAFSMKVASGAVEVGKCPH
                     MSDDAIAKLSEATAPLMKALKVGAGASEYELGGETVLFRHEKTLVSRNRYAVSFCTCM
                     SDEAVDAKIANMKKVDYVRIGEQMKVEMAVLEYCGDKDAYLKLIDKIKGSGLEVAYIL
                     ACDDAQVVKEAVEVLKDARPMVYGATKENYKDMIEVVKGASLPLGVKAGSLEELYETV
                     ELIQAAGYKELVLDVTGENIKDTYTNAIQVRRTALKEQDRTFGYPSIVFANRLSNSNP
                     MMEVALSSIFTIKYGSIIVIDDISYAKALPLFALRQNIYTDPQRPMRVEPKIYPINNP
                     DENSPVLVTVDFALTYFIVAGDIERSKVPVWLVIPDAGGYSVLTSWAAGKFGGNSISA
                     FIKESKVEEVTNCKDLIIPGKVAVLKGDIEDNLPGWNVVIGPEESMELPKFLKGYQEK
                     ACQTN"
     gene            complement(29466..30410)
                     /locus_tag="KNP36_000475"
     CDS             complement(29466..30410)
                     /locus_tag="KNP36_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA decarbonylase/synthase complex
                     subunit delta"
                     /protein_id="HBF0872369.1"
                     /translation="MAFKMSTQKYSGKISEVEVGIGEKAIKLGGENVLPFYSFDGEVG
                     NSPKIGIQISDVYPESWTDSYKELYKDVANCPVEWAKYVEANTQADFICLKFDGSDPN
                     GLDKSVDECADVAKAVIEAIKLPLVVAGSGNHEKDGKLFEKLAQTLDGHNCLFMSAVE
                     DNYKGVGASAGMAYAHKVGAESSVDINLAKQLNVLLTQLGVKGENIVMNVGCSAVGYG
                     YEYVASTMDRIRLAAFGQNDKTLQMPIITPVAFEVGHVKEAIAPIEDEPDWGCPEERT
                     IAMEVSTAASVLVGGSNAVILRHPKSIETIKELVNALA"
     gene            complement(30430..31200)
                     /locus_tag="KNP36_000476"
     CDS             complement(30430..31200)
                     /locus_tag="KNP36_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0872370.1"
                     /translation="MGYNIAVAGKGGTGKTSLTGLLIDYLVKDKKGPVLVVDADANAN
                     INEVLGIEVEATIGEIREEVNQREKLGNAFPGGMTKAQYLQFRLNSIIEEGEGYDLLV
                     MGRSEGEGCYCFVNGILREQVNKISGHYKYLVMDNEAGMEHLSRKVTRHVDTLLLVSD
                     CSRRSIQAVARIRDLAEELKLSVGRILLIVNKVPNGVMNDGVKEEIEKHNLELIGVVP
                     MDELIYEYDSTGIPLVNLPEDSKSKVAMKEIFAKLELK"
     gene            complement(31256..32641)
                     /gene="lpdA"
                     /locus_tag="KNP36_000477"
     CDS             complement(31256..32641)
                     /gene="lpdA"
                     /locus_tag="KNP36_000477"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HBF0872371.1"
                     /translation="MKIVVVGGGPGGYVAAIKASMLGADVTVVEKRRVGGTCLNAGCI
                     PTKALLASSGVLNTVKEAKDFGIEIDGTIKPNFTAIMERKNKVVNQLISGIEFLFEKR
                     GVNLVNGFGKLIDKNTIEVTKDDGTVETIKADKIILANGSVPVVPRMFPYDGKVVITS
                     DEVLGLEEIPESMLIVGGGVIGCEIGQFFRALGTEVTIVEMVDQILLNEDKDVAKQLL
                     RQFKKDKIKVITGIGVQTCEVVDGKAVATLSNGKVIEAQYALVCVGRRPNLDNSGVED
                     IGIEMERGKVVVNEHLETNVEGIYAIGDIIDTPFLAHVASKEGIVAVENALGKTKVVD
                     YRAIPRCVYTEPEVAGVGKTEKQLEAEGVEYNVGQFDFRGLGKAQAIGHFQGFVKVIA
                     DKETDKIIGAAVVGPHATDLLTELSLAVHLGLTVEQVGDAIHPHPSLSEGLMEALHDV
                     HGECVHSVPKL"
     gene            complement(32685..33566)
                     /locus_tag="KNP36_000478"
     CDS             complement(32685..33566)
                     /locus_tag="KNP36_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="HBF0872372.1"
                     /translation="MSLLRETLESGKFAVTTEMAPPKGTDLSHLIECAKPLVGRVHAA
                     NVTDFQSAVMRATSLATCKLLKDAGLEPVIQITGRDRNRIAIQGEMLSAGVFGINNLL
                     ALTGDHTSVGDHPQAKGVFDLDSVGILQTAETLMAGTDMAGNKLKGSPDFYLGASVTP
                     EYSPIEVQLLKMKKKIKAGAKFFQTQALYDINTMRKFRELTRDMDCKVLAGIVPLKSP
                     GMAKFMTANVPGIFVPDEQIERLRAAGKENWVSEGIKMAGELIKQLKEEDLCDGVHIM
                     AIGAEENIPAILDAAGL"
     gene            complement(33601..34275)
                     /locus_tag="KNP36_000479"
     CDS             complement(33601..34275)
                     /locus_tag="KNP36_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase C-terminal
                     domain-containing protein"
                     /protein_id="HBF0872373.1"
                     /translation="MIISENKPLEEVLGYLKDFDKLVLVGCNQCAATCKSGGEEEVLK
                     MKETLEGEGKKILGYVMLDPACNLLKSKKDLKALKEETKEADAVLSLACGDGTQTIVK
                     NLKDKPVYPANNTLFIGEVQRVGEYEEACKACGDCELGWTGGICPVTMCAKGLMNGAC
                     GGAKNGKCEVNSENDCAWIKIYERLEAIGQLDNLAEIRPPKDYSKQNNPRSLSAKKKK
                     EAAANS"
     gene            complement(34312..35184)
                     /locus_tag="KNP36_000480"
     CDS             complement(34312..35184)
                     /locus_tag="KNP36_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 5,10-methylene-tetrahydrofolate
                     dehydrogenase/5,10-methylene-tetrahydrofolate
                     cyclohydrolase"
                     /protein_id="HBF0872374.1"
                     /translation="MEGMSTKGQIIKGKPVADKISEELIKEVDLLIKEGINPKLTIVR
                     VGARSDDLSYERGALKRCQNIGITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCF
                     RPLPKHLNEEVIKYVIAPEKDVDCFSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNV
                     DLKGSKVTVLGRSMVVGKPVSMLLLSEHATVTICHSKTKNLSGVAAEADVLIAAIGRA
                     KMVDESFVKDGAVVIDVGINVDEEGNLCGDVDTNAVLDKVSMITPVPAGVGSVTTSIL
                     AKHVVKACKLQNNK"
     gene            complement(35276..35908)
                     /locus_tag="KNP36_000481"
     CDS             complement(35276..35908)
                     /locus_tag="KNP36_000481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclodeaminase/cyclohydrolase family protein"
                     /protein_id="HBF0872375.1"
                     /translation="MKIADKTCVDFVEVLSSKEAVPGGGGAAALVGAIGMALGSMVCN
                     LTIGKKKYAEYEESVKEILSKAGKLEKDLLKMIDDDAECFLPLSKAYGLPKETEEEKR
                     IKAETMEKALKVACEVPLNIVRVCYEAIKLHEDLVDKGSRLAISDVGVGVQCLRAAIL
                     GGQLNVVININSIQDKEYVNKVKTEVDKLVEDGVKICDEVYAKVEKALGK"
     gene            complement(36013..37689)
                     /locus_tag="KNP36_000482"
     CDS             complement(36013..37689)
                     /locus_tag="KNP36_000482"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014355320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HBF0872376.1"
                     /translation="MGFKSDIEIAQEAKPQDIREVAKKLGLGEDDVELYGKYKAKVDY
                     NLLKRETGKKAKLILTTAINPTPAGEGKTTTTIGVADAFAKLDKNVLVALREPSLGPV
                     FGVKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMLDNHIHQGNALRIDPK
                     KITWRRCVDMNDRQLRNIVDGMGKKGDGAVRQDGFDITVASEIMAAFCLASDISDLKE
                     RLGNIIVGYSYEGEPVTARQLKANGAMAALLKDALKPNLVQTLEGTPSFVHGGPFANI
                     AHGCNSVIATRMAMHFADYVITEAGFGADLGAEKFLDIKCRMANLKPDAVIIVATVRA
                     LKYNGGVAKADLNNENLEALEKGLPNLLKHVENITQVYGLPAVVAINRFPLDTEAELK
                     LVEDKCKELGVNVALSEVWAKGGEGGIAVAKEVLRLLDEEENNFRFCYEDDLSIKDKI
                     NAIATKIYGADGVDYTPEADKEIANLEKLGFTKVPVCMAKTQYSLTDDQTKLGRPTGF
                     RITVRQATISAGAGFIVALTGEIMKMPGLPKVPAAEKIDVDENGVIAGLF"
     gene            complement(37938..38717)
                     /locus_tag="KNP36_000483"
     CDS             complement(37938..38717)
                     /locus_tag="KNP36_000483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0872377.1"
                     /translation="MKIAITGKGGVGKTTFSSMLSRMFAEDGYRVVAVDADPDANLAL
                     ALGFPKEVYESIVPISEMKKLVSDRTAASVGSFGKMFKMNPKVDDIPENFCKEYNGVR
                     LLTLGTVDSGGTGCVCPEHVLLKRLCSHLILQNKDVVVMDMEAGIEHLGRGTAQGVDA
                     FIVVVEPGERSLQTYRKVKKLGHDIGVNKVFVVGNKIRNKEDEEFIIQNLEDGESLGF
                     IYYNQDVIDSDRANQSPYDSSETTKEQIKAIKDKLMSLKDK"
     gene            complement(39027..40946)
                     /gene="cooS"
                     /locus_tag="KNP36_000484"
     CDS             complement(39027..40946)
                     /gene="cooS"
                     /locus_tag="KNP36_000484"
                     /EC_number="1.2.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic carbon-monoxide dehydrogenase
                     catalytic subunit"
                     /protein_id="HBF0872378.1"
                     /translation="MDEKMLTIDLNSQKMIAKAREEGVETMYDRKEGFKAQCGFGLQG
                     VCCRICGMGPCRISPKTPRGLCGADEHTIVGRNFARMVAGGTAAHSDHARDIAHTLAL
                     ADPNGNYKIRDEAKLITLAKEWDVETEGRDIYDVAHEVAEIALMEFGKPFGTLRFIKN
                     APEPRQKIWKEYAIEPRAIDREIATIMHSTHIGCTGDIDSLIHMSLRTSMADGWGGSM
                     IGTRLSDILFGTPVPRRTEANLAVLEENKVNIILHGHEPALSEMIVLASEEPDLVALA
                     KEVGADGINLAGMCCTGNEITMRHGVKIAGDFHQQELAIITGAVEAVIVDVQCIFPAL
                     ARVADCYHTKFVTTSPKAKITGSTYIEFREEQALDDAKAIVKEAILNFKNRDKSKVLI
                     PELKSGATVGYSVEAVVNQLDRVVNSHIDPAGTVKPLTDCLKSGVLRGAAGVVGCNNA
                     KGVSNEAHVTIMKELIKNDIIVVTTGCGASAAAKFGLMESDAAEKYAGKGLATVCKLV
                     GIPPVLHMGSCVDISRILDLVGAAANYLDMDMCDLPVVGIAPEWMSEKAVAIGCYVVA
                     SGIDTYLGIMPPIAGSSRAVDILTSELKDKVGATFTVNTNPKELAATIIEDIEKKRVH
                     FEALVEEKMAEKAEA"
     gene            complement(41553..42464)
                     /locus_tag="KNP36_000485"
     CDS             complement(41553..42464)
                     /locus_tag="KNP36_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional enoyl-CoA hydratase/phosphate
                     acetyltransferase"
                     /protein_id="HBF0872379.1"
                     /translation="MIKKLDDILEQLKGGEKIVLSVAAAHDKEVLMAIKDAVERNIIT
                     PILVGNEGKIREISKEIGFDLSGIKIVDKDDIKECAEIAVKLVSSKEADFVMKGLLDT
                     SVILKEVLNKDYGLRTDSLLSHVMVYELEKYHKLLITTDGGMNIAPDYEQKAKILKNS
                     IKAAKALGMETVKVACLAAKEKVNPKMQATVDADMLAKACKEGEFGENVIVEGPLAFD
                     LAVSKEASEIKGFKSEVSGDVDIILVPTIEVGNGIGKAFTYMADSKSAGIIMGAKAPI
                     VLVSRADSHESKLYSIAYGAIVAKNMK"
     gene            complement(42580..43158)
                     /locus_tag="KNP36_000486"
     CDS             complement(42580..43158)
                     /locus_tag="KNP36_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBF0872380.1"
                     /translation="MNINEFLTHINQRKPVSSKSEIHEFMVKLSNEAMKITSKLNSSY
                     HEPEEVRSLFSELIGKKVDESFFMFPPFYTDCGKNITIGKNVFINSSCHFQDQGGIEI
                     GDNTQIGHNVVLATLNHGIAPEKRGTTYPSPITIGKNVWIGANVTVVPGVTIGDNAII
                     AAGAVVTKNVAENTIVGGVPAKLLRVIDEIPE"
     gene            43384..44307
                     /locus_tag="KNP36_000487"
     CDS             43384..44307
                     /locus_tag="KNP36_000487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0872381.1"
                     /translation="MEIRVLRYFLAIAREESISGAATFLHITQPTLSRQIMELEEELG
                     VKLLVRGNRKITLTNEGRLLHKRAEEIISLVDKVELEFDNPNEIISGDIYIGSGETEA
                     MRLIARTAHHFHQKYPNVRYHLFSGNADDVTEKLDKGLLDFGILIEPANIQKYDYAQI
                     PATDVWGLLMRKDSALASQSTINPKDLCNIPLIISRQTLVDKAISKWLQDSNEKLNII
                     ATYNLVYNASLLVEEGLGYALCLDRLVNTTENSNLCFRPLSPPLEAKLNIIWKKHQIF
                     SKAAEKFLLQIQKDFSSIMLDTSKLDTPKEK"
     gene            complement(44479..45621)
                     /locus_tag="KNP36_000488"
     CDS             complement(44479..45621)
                     /locus_tag="KNP36_000488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBF0872382.1"
                     /translation="MDFKIEKYLLKKAEELAFITIKHGGEFKLKSYEVPKGGLDVPIK
                     NEVLVKGIKEKTAQDKLNSMSIADAMIYIIGIDSKFKNNAEYEKFLNALSKDIDLDLK
                     SYMGYMSRKYFEIGEHTDSLIYIKAFITMYPDDLDAMYNYAIVCQEIAKQYQKDMDDK
                     AMNAFLLEAMAKLEKVIDVDENFALGYYHLGYHYYNQGQYLKTKLTWEEALRLGLDAD
                     LVAEVQENLGKMDFKVQYEEGYTLVFQGKFKEGLEKLLPLEEEHMDWWNLLFMIALGY
                     KGMGEIEQAKMYLEKILIIKPNQVDTIVELGLCEAYKNNLDKAIEYFEQAAKIKEDPE
                     ILCNLGMAYLNNGDIDDATYYIERAYELNPQDEITIACLRELRINK"
     gene            complement(45639..47393)
                     /locus_tag="KNP36_000489"
     CDS             complement(45639..47393)
                     /locus_tag="KNP36_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B12-binding domain-containing radical SAM
                     protein"
                     /protein_id="HBF0872383.1"
                     /translation="MKILLTTLNSKFIHTNLAIRYLKEFVRDLIEVNMKEYTINNDLD
                     YILKDIYKNEYDIILFSTYIWNVGDIVKLCDNLKKIRPNTKIALGGPEVSYDSYEAMK
                     KYDFVDYILYGEGELIFRDLVLHLQGKMEINDVNGLVYRQGNEIIVNKPMELLQDLDE
                     IPSPYENLNPKEYENRIVYYESSRGCPFNCQYCLSSTIPGLRYFSLDRIKSDLKALID
                     ARVSQIKFIDRTFNANRKVAMEIMDFLMKNDNGYTTYHFEVTAYLIDDKMLEFLADCK
                     EGLFQFEIGVQSTNEKTLDAVGRRDDFKKLSHVVQTVASYRNIHQHLDLIAGLPYEDY
                     KSFENSFNDVFNLGIEHLQLGFLKMIKGTGMRKVADEHGFKYKDYAPYEFLYNNYISY
                     EETLKLKDIEDILERYYNSKNFVLSMRYIIGRFYKKSPFKFFEVFAKYFDENGYFDLA
                     QGKNQLYKILMDFYNEKINIDNDVFNDILKYDYISLGKTSNIPQFFNKLDVDDFKNRC
                     HVFLQDNDNLSTYLPSFVDKPAKHIIKYVHFEPFRFNVVDLKNDINTEIREVENVVLF
                     EYDDKKIFEKSKTHKVEI"
     gene            47529..47735
                     /locus_tag="KNP36_000490"
     CDS             47529..47735
                     /locus_tag="KNP36_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872384.1"
                     /translation="MELIEKVSINSLSKRDLLLIIKSLEYTNENTQISDFIDLRNNIV
                     KELCFLTDTKEKDFLDYLEKNSTL"
     gene            complement(47740..48663)
                     /locus_tag="KNP36_000491"
     CDS             complement(47740..48663)
                     /locus_tag="KNP36_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872385.1"
                     /translation="MNDELLKKVYTSSFSSASRALKDLTIINTKSLIDDKTQRCVYID
                     ENRLRDELIYYRFYGEKIGNINFLNILLPLILSNTNIQKSEDEVIKLIKKYVIYFKKE
                     ELLFDYLLGSVVYNSIMHNLINNSKIEYVELLQSIKDKIIGFSIELDKSDVVKFQMAR
                     IKAIQLIDKYIDLKSEDYDEESILLNVLNVLYDVYMEDRTVENEGINSIKKSILSILG
                     EDSKLNEDNIDFIFSMSEYVVKLRKYKIGVKAYNKSIDPRSLIRLEEGNTIIDPIFNQ
                     ITVMSKTFNDNILSIKINSKSGIYILKFKKV"
     gene            complement(48917..50617)
                     /locus_tag="KNP36_000492"
     CDS             complement(48917..50617)
                     /locus_tag="KNP36_000492"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HBF0872386.1"
                     /translation="MQDFKVAISNCLKEKIEDLSKEEIEALIEVPPNKDMGDYAFPCF
                     KLAKVFRKAPNMIASELAESIEPSGEITKVIQLGGYVNFFVNKSQLAETVIKKVLDEK
                     ENYGHSDFGKDKTVIVEYSSPNIAKPFHIGHIRTTVIGNALYKIYDSQGYKTIRINHL
                     GDYGTQFGKLIVAFKKWGEKEVVESNPIPELLKLYVRFHDEAEQHPEMEDEARAWFNK
                     LENGDEEAQELWQWFRNESLKEFNRVYKLLDIEFDSLAGESFYSDKMNRVIELLEEKN
                     LLKESKGARIVDLEEYKMPPALITKNDGSTLYMTRDLAAAIYRKETYDFDKCIYVVGS
                     QQNLHFQQWFKVIELMGYDWAKDLIHVGFGMVALEEGTMSTRKGRVVFLEDALNQAID
                     KTKEIILAKNPNAKNVDEISKQVGVGAVVFQELSNSRIKDYTFSWERTLSFDGETGPY
                     VQYTHARCCAVLRKAEVEVTSDIDYSLLADEDSAEVLRVIESFNKNILLALKKNEPHI
                     VTRFMLDLAQAFNKFYHDNPILVENLEIRKARLALVLATKQTLENSLKLLGMHAPERM
                     "
     gene            complement(51079..51492)
                     /locus_tag="KNP36_000493"
     CDS             complement(51079..51492)
                     /locus_tag="KNP36_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBF0872387.1"
                     /translation="MILVSACLIGINCKYSGDNNDNEKVKEYLKGKEFTLVCPEQLGG
                     LSTPRPPAEIVDGKVITKDNKDVTENFVRGANETLKIANLYVCSEAILKEGSPSCGCN
                     LIYDGSFSGKKIPGKGITARLLEEEGIKVKSEKDL"
     gene            complement(51560..53938)
                     /locus_tag="KNP36_000494"
     CDS             complement(51560..53938)
                     /locus_tag="KNP36_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HBF0872388.1"
                     /translation="MNEKSLRVLEYNKIIDLLKKKASSSLGLKYIENLVPNTDFVEVK
                     SMLEETSEAQSIIIKRGSVGLEGIHDIEDKVKRAYIGASLDPGSLIMIADTLRVARRL
                     RNSLSSSDEEDFNYPIIQSLSNSLYVYKDIEDQIYNAIISEVEISDNASSTLRDIRRR
                     IAQKNQSIRSKLNSIISSTTYQKYLQDAIISLRGDRFVVPVKSEYRSQVAGIVHDQSS
                     SGATLFIEPMTIVEMNNELRQLKLGEQEEIERILSELSAMVGEVSEDLISNQEILGRL
                     DFAFSKGKLSIQMRGIEPTLNEDKYLNIKNGRHPLLDKKKVVANTIYLGRDFHTLVIT
                     GPNTGGKTVTIKTVGLFALMTQSGLHIPADYGSSMCVYDNVFADIGDEQSIEQSLSTF
                     SSHMTNIVSILQNVTADSLVIFDELGAGTDPVEGAALAIAVLEDINSVGAKCIATTHY
                     SELKNYALTKPGVENAAVEFDIETLSPTYKLLIGVPGKSNAFEISRKLGLSDYVISRA
                     KEYINTENIALEDVLQNVEKNRIKAVEDREEAERLKEEIEKLKVEYDEKLEKLVSQRD
                     KMIEKAKSEAFSIIRQAKEEVDIIIKELRSLEQERASKEKNRKIEELRKELTSSMGSL
                     QPTVKSMIVPKVSNKEIKDLKPGEEVKVITLNQNGSVVSVDKKRKEAVVQIGIMKMTL
                     PFKSLQKTRKDVSTNVTKSTRNIIRSKSGSVKNEVDLRGLNLEEAIMEVEKYLDDAYV
                     AGLESVTVIHGIGTGVLKAGLQDILRRNRHVKSQRGGQYGEGGAGVTIVKLK"
     gene            54257..55708
                     /locus_tag="KNP36_000495"
     CDS             54257..55708
                     /locus_tag="KNP36_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-histidine dipeptidase"
                     /protein_id="HBF0872389.1"
                     /translation="MGNVLEGLKPESVFKNFEKISQIPRGSGNEKGISDFLLSFGKNL
                     GLETIQDESLNIIIRKPATKGYENCPGVVLQGHMDMVCEKEKNVEHDFLKDPIKLRID
                     GDMIYATGTTLGADNGIAVAMGMAILEDNTLEHPALEVLVTVNEEDGMNGADALDPSL
                     IKGQYILNMDSEEEGYLLVSCAGGKTCVVSLPVEYKEVKGDKQGLLVEVTGLLGGHSG
                     MEIVLQRANANKAIARVLSVLNVDYELASVDGGTKHNAIPREAKCVIAVNKADVESAK
                     KQINDILTAFKHEFTTSDPGMTYSVAETSVDKVLTKDCKEKVVQMSCLTPHGVQSVSL
                     DIEGLVESSTNFAIIETKESTIEFLTSVRSSVMSIRDEIADRIRLLAQALGANYDLIA
                     QYPAWEFKKGSKLEKICSETYEKLTGKVPTVMALHAGLECGLLLDKLPHAEAISIGPD
                     MFDVHTPNEHVSIPSVANVWDYVIEILKSMNQY"
     gene            complement(55912..58425)
                     /locus_tag="KNP36_000496"
     CDS             complement(55912..58425)
                     /locus_tag="KNP36_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBF0872390.1"
                     /translation="MEDCVVNLKKLLLLIIVITSIFTSCIFSFGINAIGNDNRTIRVA
                     YPIQKGLTEIDEQGNYFGYTYEYLLEIAQYTGWNYEFVQVPGEINESITKLMKMLENG
                     EIDIMGGMLYNEPMQKIYNYAGNSYGVANTVLQALYENTDIDNIMSSQDVKKIRIAVI
                     ENSDTRLKELDEYCKMNLMSPELVYCKTNDEQLEALKSGKADVLLNVSMNPLEGVRTV
                     AKFSSKPFYFITPKGSTNLTQKLNSAINNIEQKDPYFSTTLYEKYFTPENNQMFLSDE
                     ETDYIKETEKLKVGVLLNKPPFQNIDKDTGELRGISIDLLNHICDKTGLEFELVPVKS
                     QEDLENMTKKREIDIVAGMIYDYEYSREHNIVMSRPFLSTQYTMMINNKLNENSLDGK
                     RVALAKGINYYGQFEENIVWYDNLEECIEAVNKGYADYTYGEGYSMQYYMNQPKYKNV
                     RLVPQTYKAKSICFGIIKKDKQELLNIFNKAIISISSEKMQSIVYQNTTYRQDFSLLY
                     IMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEKISLELKKHTQLYEMTSEYFFE
                     YDYKQDKLIISMPEKGIETYYGLDKNDKESENGNIENERDKIRKEYNKKFFDVIKSQE
                     NGTTEMYSIMLDDTFHWIRVTSKIIYNDRKIPMYVIGKICNIDSEKEEKNRLLDKAQR
                     DSLTNIYNAAYIRKLTAQNLLNLSTEKNGALLIIDIDYFKSINDTYGHLLGDKVLIDV
                     AKVLDESFAKNDIVGRLGGDEFSVYINDIINKEELINKCNDVYNHIHLIKLPNGESLS
                     ISMGVVIAKPGQEYDELYQIADNALYDSKRQGRNRFKIV"
     gene            complement(58648..59469)
                     /locus_tag="KNP36_000497"
     CDS             complement(58648..59469)
                     /locus_tag="KNP36_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0872391.1"
                     /translation="MIDINLEKCVGCGMCESDCLVNAIKVKDDKAKVKNILCINCGHC
                     MAICPTDAIEMQGFDKNEVIEYNRESFELEPEKLLNFIKFRRSIRQYKDIEVEEEKIK
                     NIVEAGRYTPTGGNRQPIRYILVKEKLKEVKELAIQGLYNLALDTDDNDPVRSIYKNT
                     FKKMYKRYKENGNDSLFYDAPLLMVVVGDMSLGGSAYVDGGLAASNMELMAYSQGLGI
                     CYNGFFVMASNVEPKIKELLGMSENEAVITSFILGYPDVKYKRTVNRNTAKFEVR"
     gene            complement(59987..60463)
                     /locus_tag="KNP36_000498"
     CDS             complement(59987..60463)
                     /locus_tag="KNP36_000498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HBF0872392.1"
                     /translation="MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGET
                     PEECVIREVKEETGLTLKSLSYKGLITFPKFKDEEDWYMFLYFSDEFEGELSEKDLND
                     CKEGNLIWVDNDKIFDLNMWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD"
     gene            complement(60497..61075)
                     /locus_tag="KNP36_000499"
     CDS             complement(60497..61075)
                     /locus_tag="KNP36_000499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HBF0872393.1"
                     /translation="MREEALEILFKYLETDRMRKHCYAVEAVMRELAKRLEPEKEEEW
                     AVAGLLHDLDSDIVGRKPGEICEGHATTTVELLKKENFGDEEMYRAILGHHDGMGVTR
                     TSLMEKAIYAADPITGFITAIALVYPDKKLTSVKTKSVIKRMKETRFASNVNRDAMRS
                     IEDIGIPFDEFAELSLNAMKNISDVLESAENN"
     gene            complement(61179..63761)
                     /locus_tag="KNP36_000500"
     CDS             complement(61179..63761)
                     /locus_tag="KNP36_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HBF0872394.1"
                     /translation="MKKIELLAPVGSFDSLKAAVQNGANAVYLGGKDFSARASANNFD
                     RNELIEAVKYSHIRGVQVFVTVNTLIKQYEIEDFVEYVKFLYDIDIDALIVQDIGMAR
                     LIKKLLPDFELHASTQMVAHSLEDVKYLQSVGFDRVVLARELNVDEIKWICENTTVDI
                     EVFVHGALCVCYSGQCLMSSMIGNRSGNRGRCAQPCRQKYELIDINTGEVVKSNGDYL
                     LSPRDLSTIEDLDKIIEAGVLSLKIEGRMKKPEYVATVVSGYREAINEFVDKKKISIS
                     EEIINNLYTIFNRKFTKGYILGEVGKDIMNSNRPNNQGLYIGKVLDYNRKNKRLRVML
                     ENTLKKGDGINLGGGTIGRIIKDGEITTIAHKGDLIELDFVGEAKRNQLIYKTSDSEL
                     MDRVQATFQQDKEFIKTNIRAKVSIKLGKKPELFISDFCGNKSVVEGDKIVEKAIKVA
                     LSKEKIETQIQKLGNTPYKLKEIEIDLDEGVSMPISVLNQMRRDCIELLDEERIKIKD
                     RKFKKNRLKYQPNRVNKQKKLDTVPKIRVKVKNLEQLEAVLNYNVDLIYYEDINTLSK
                     ALQMVSSISIDSSISMDLYTSSSLGIPKELMGSNTNNIYTLSNTSKIDTLNKNHSNTA
                     VTDKKLIYSAPRIVRNKEYKQFEILDNIKGINKVQIGNWGSMEYFKKKDLNIDCYLNA
                     FNSESINHFKEEGASTVCLSQELNLNEIKQTLKYTDVEIEAVIYGYAPMMVTEYCPMG
                     VVVRDCKKDKRVAKCKESSYALRDFTDASYRITQDIFCRSTIYNSKVTCMLDNLYELE
                     EIGIDVFRIDFTVEDSEMVKKVIEAHIEVLSNNYKLGKRATDLYKKLDEIGTVAGHYY
                     KGVE"
     gene            complement(64331..65014)
                     /locus_tag="KNP36_000501"
     CDS             complement(64331..65014)
                     /locus_tag="KNP36_000501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HBF0872395.1"
                     /translation="MTSKSQMSESFFLCSLLAITGGFLDIYTYVVRGKVFANAQTGNI
                     VLFGLNIAEGNVKESFYYLIPILAFMLGVFIAEKIRKYFTNNKTKIHWRQVIIIIEMI
                     TILIVSFIPRGRFNMFVNVAISFICSMQVESFRKVNGNSFATTMCTGNLRSATETLFH
                     YIHTKNIFMIKKSLQYYAIIIFFISGAILGTFFTKIFVEKSILICFFILAVVFGIMFI
                     NKDDSFNEN"
BASE COUNT        20351 a        12158 c         7162 g        25509 t
ORIGIN      
        1 gcttttcttt aataatacta aataatattt tccacattgt tgctttttct aaacaactat
       61 aaataatata ttaaaccctt atttcttttt ctaataagtt aaataataca ttttacacat
      121 atctatttgt cttgcacata ataaataata cattatattt ctatctaaat ttagattcta
      181 aattaaatag tataaattat attcttcaat aaacaagttt tcaaatccaa gattcgctct
      241 ctatctttaa actttattgt aaacataatt ccatcttttt taattatttc tccttcatga
      301 aattttttat ggtatacctt atcccctaca ccaatactgt caatttcttt tttcgttgga
      361 gattttatat cattaataaa taatgattta tcaactttct taccatactt atttaaagta
      421 gagcttatac ataacttttc ttcagctctt gtaatagcaa catacataag tcttctttct
      481 tcttctaatt gttcttcttt tttctcttcc ttacaaatat catatgattt ttcatgaggt
      541 attgttcctt catttacacc tataatataa acatttctaa attctaatcc ttttgcacta
      601 tgcatagttg taaatatgac accctcagtc tgcttattct tgttattttc cgttaactca
      661 gtctttactc tatcaatatg ctctaaaaac tctgtaacag tattaaaatt agttgctgaa
      721 ctctcaagtt catttaatat ctctacaagt ccattagtct ttatctttct gttgctacaa
      781 taatctaaaa catatctatc ataatcaaga ctagttctaa tataagatat tgcattttta
      841 ggatttaaag tatttaaata acttaaatct atttccaaat catttattgt tttaacttgt
      901 ttaggatgaa gattacactt atttattaat gctgttataa agtctttttc atccttaacc
      961 atatttatac tgtctttgga tatatatcta aaaggcttgt ttataattct caaccaatct
     1021 ttatttgatt ttggattaat acctattctt aaataggcta gtatgtcttg acttgcccaa
     1081 tggtcatata ttgtaattac tgagtctttt actacaaatg gaatcctcat atccataaat
     1141 acatctacta atgctcttga ctgtatatta gttctataaa ttactgcaaa atctgaatac
     1201 tctacataat ctttttgtat ttcgtcaatt atttccctgg caatatataa ggcttcttcc
     1261 tctgaatcat gcggagaaat ataggtaaca cttcctccat ccccctgact acacttaatg
     1321 attttttcat atctattttt atttttgtcg ataagtctat ttgcagtatg aactatctca
     1381 cttttagacc tgtaatttat atctaatatt atttttttag tattattaaa gtattgttca
     1441 aattcaagca aaaaatctgg tctagcacct ctaaatccat atatactttg gtcttcatct
     1501 ccaactgcaa atatattgtt taatgggcta caaattaact ttaaaacttc aaactgtact
     1561 ttatttatat cttgaaattc atctatcaat atatatttat acacatttct aaccatttct
     1621 agtgcagact tattgttcaa aagtaaataa taagttctta taagcatatc atcaaaatct
     1681 attttattaa ctttagattt ttgttcttcg tataagttgt atacttttaa aaactcatct
     1741 tttgttaata cttctgaatt aaattcattt ttatccataa gttcattttt tacataggaa
     1801 atttcattta taacttgtcc tatattctca tcatcatcag cattctctat atttaaactt
     1861 tttaggattg ccttgattgt cattcgcttt gacttttcat caaatatact gtctaagttg
     1921 tatctttcaa agtatcttag aattttaaaa aatacagagt gaaaagtacc ataggttacc
     1981 ttattaagtc ttatgtcatc acttaaattc aaagctctat ttttcatttc tattgaagat
     2041 gccttggtaa aacttattgc caagattctt gttggtgcta tgtttttgtt tacaaccata
     2101 ttggctattc tatatgtaat tactctggtc ttacctgaac caggccctgc aagtatcatg
     2161 caaggcccat ctatatgctc aactgcttct aattgatttt catttaactt tcttatatct
     2221 atatttgttg tgattattag ctccaccacc ttgatttata attatattat tttcttttta
     2281 attataaact aaaagttcat aaaaataaat ttaatttttc ctctattaaa ccacatcatt
     2341 cctattttca tgacatatct tgagttcttt tttaattttg tcgcttatat cttcaggtat
     2401 aaatgatggt ttactaatat agtagccttg catataatct actccaagat taattagtgt
     2461 ttccatttca ccttttgttt ctacaccttc tgctatcact ttaatatttc tttcgttaga
     2521 atatgagata agatttttta atattttctg tctgttttca tctttatcaa tacctcttac
     2581 aatagacata tcaatcttta catagtctgg cattatatat aatagtacag catctccgtt
     2641 gtaacctgtc ccaaagtcat ctaaagcaat ttctatattc caatggtcta tatatgcttt
     2701 ctttttctca ataaaatctt cattaatctt atcattctct gttatttcta gtactactct
     2761 atttaaatat tcaccatata aatcttcaat ttcctcaaaa tctacttttg acaaattatt
     2821 attaggaata gaatttaaga acagtttgca atcgccaaat ttttctttgt attttttaaa
     2881 tgatttaagt gctttaaacc atgtaatacg ctcaatttga tataatttag actgtgaacg
     2941 agctaatcta atgacatcta ttggcgaact aaaagttttt attttaggtc tcataagtgc
     3001 ttcatatgca aaaactttac ctttacaatc tacaataggc tgaaatgcat actcaactaa
     3061 ttgaccatca attaacttgt ttaattcttc tctattactc aataagaatg aatccttatt
     3121 atatatatta atatcaaatt cactaacttc acccttgatt gtatttttaa tttgatacat
     3181 agcaaaatct gcgtatctca ttaattcatc atagttggtt gagtcatcag ggtaccagga
     3241 aattcctgct gatgccctta ttttaaattc tgttccatca tgaagtttta ataaggtatt
     3301 attcatctgt ttcttaacag aattaataat atctcttata ctatctttac tttcatatcc
     3361 atatataaat acataaaact catcacctga aagtctagat actataccat tccatgatat
     3421 aaacttctta agtatgtctg cagcacacct aatatattca tcaccagcat catgtccata
     3481 tgtatcatta atatatttta gattatctaa atcccacata ataaatgctg ctatcttaag
     3541 ttcatcttta ttcttaaatt tttcttgtat ctgtgaatga aaagctctcc tatttaaaag
     3601 attcgttaaa atatcaaaat ctctttcata ttctatcttc cttttctcaa taaattcttt
     3661 tgttacatca acaacaacac caagaacctt tagctcatct tcaaagatat tcattcttat
     3721 ccacttaagt tttttatctt tagattcaaa cttatatata tatgtatttt ctgtttcata
     3781 actttcttgc aaatatttat ctagtcccct taattttttc aggaacttat ttttttccat
     3841 atatccatat tcttcaaatt tgatttcagt agtaaacacg ctaaaaaatt cttttgtaca
     3901 aaaaacattc tctgcgtttt tgtataactc aaaagctcca attggcatat ctaccatttc
     3961 aataatctgt gataattttg acgaagaatc tgcaacattt gcactgagca actctatagc
     4021 tgaagataat tcatctattt cagatatatt tatcttatca agatttactg gttttgatgg
     4081 attactgttt ctaactttgt tggctaaaag aacaattggt tttgtaaata atcttgatgc
     4141 aatataaata cctattagac ctattaataa agaaattgct atagatatta taactaattt
     4201 ctctaccctt tttgaaaatg acaaaagact tttttcttca ataataccca aaagagccca
     4261 acgttcattt tcaaatggag tattggagtt atataaatct aagtattgta cactagcata
     4321 aatgttgcca ttaccacatt cattatcttt atttttaatc ttatatatat ttttatacga
     4381 ttccttctgc tctaaattag aatgtaaacc atcccaaaat ttttctttta atgagtatcc
     4441 atttgaaatt acattttcaa aggccatatc attatttcta tctacaccta aaatataatt
     4501 acccttttta ttcccattta tctctgagta tggaagtaat tctcttaaat aatttacact
     4561 taaatctatt ccaagtactc catatacagt tccatcttca taaataaggg gaactgtata
     4621 tgtcataagc ctatcacctg catttgtcaa taaaaactta cttccccagt atcctaaatt
     4681 agaacttgat acatttggat tatcaattgc agctctaaat ggtttataaa aaaaatcatc
     4741 tccatcttgc tcattttcac ttttaaatga aaacttaggt tcccaataac tgtccataga
     4801 tattccaaaa cttcttgcta tatctgatga acctctctca attaacaaat cagaattatc
     4861 atttggatta aacttagggt ctaaatccct tatatacaat cctgtcctac ttatttcacc
     4921 tttactatct attgacttat cgttaatatt tttgtcactt aggattataa aagctcctgt
     4981 aacagaattt tttctcaaaa gatatattaa atcatttgat atgcttttta taatatcttt
     5041 gttaatttct tcattgttgc ctacatcctc aattaaggca tttttttcat ttaatacttt
     5101 ttttacagag gaattaattg tagcttccgt ttcacttgta tttgaccatc tttgtaacat
     5161 ttcattttgt atataatttt tacgattaat tactctttca tttaagatgt caaacgaatt
     5221 atcatttaat ttcttaatag ttcctcccca taaaattgtg gcacaaaata aacttgtttg
     5281 aattagcata acaataatta ggggaaatat catctttttc attattgaat tgttttttct
     5341 tagattgttt tccataccca ttccacctat acctttgtgc tcgtcaacac actaactgcc
     5401 aattcatcta tttttttata gcattttcaa gctcagcctt aaaactttca aaccaagttt
     5461 taaaattttt atcattatta aattgtgcta ctgcatcctt cttagaagtt ccacttttta
     5521 ctaattcatt tattttattt gaatcttctt tagctttatc aagcattgaa tattcaagta
     5581 tttgtctagc tttagttcca ccatcaaatg ctttattagt atataaatta caactgttaa
     5641 tctgttcaat agatgaggct attgaacctt caactttatc agacaaactc aaattatctt
     5701 tcttcataac ttcttttata acatccaaat cattcgtttt tttctttact ggtaagtatc
     5761 cagaagcaat agagaatttt atattaggtt ctttatctgt aaaccatttt aaaaattcta
     5821 ctgatgcata ttcttcttct ttagtagatt ttgttacagc cattcctgca ccttgttgta
     5881 cagcatattt tccttctcct ttaaaacgtg gtgcttgaaa aacagatgtt tcaatattat
     5941 aactctcatt atcatttagc attactctat ctggaaagta tgctgctcct gaactagaac
     6001 ctacaagagc taatatatca cctgtttttg catcatcaga acgaaactta ccataagaag
     6061 caaaatatcc atttatatat ggtacataga aattatccca tagttttttc ataacttttt
     6121 catcaatatt tagcgtaact ttaccatctt taacagaaaa aatttctact cctagttgtt
     6181 tacttcctat aataatataa tttgctaaag catctcttcc aaaaaatgct ttaccatcat
     6241 taggctcttt cgttaaacta tctgtccatt cataatattt ttttgatgtc tctactaatc
     6301 cttcaattgt ttttatatca tttatatttg aatttgtagc ttttgcaaat ttatcccaat
     6361 cagttttatt taacatcaaa atttcagttg attttgcaat tgggaaaagt ttaaactcat
     6421 ccttagaatt tattctgcct tcttctacat attcgtctat gtattcattt aattcttctt
     6481 tacttatgta cttatccata tctactagta accctaattt atccatttca tatgcagtat
     6541 ctgagtatgc tgcaaatata tttggtacat cttcagaacc aactttttta tttgcagaat
     6601 ctaaaacttt ctctgataaa tcaactacat taccttgact gaatgcttca acaataattc
     6661 ctttttcagc acctacagtg tcattaaatt ccttaacaag cttatcaaaa gccattttct
     6721 gctgtccatt ataataatgc caaatttgta ttgatgtcgg attttctggg tctaacttat
     6781 aattatcttc cttctttaaa ctacatcctg taagtaataa aacaatcatt gatgtgataa
     6841 ttaattttgc aaacttacac ctattcataa aatctactcc ttcaaattat aaaatttata
     6901 atagcattaa aactgtaact tcactattta tattaattat agaacgttta ttgatatatt
     6961 taaacaggat ttacaacata tttaaaagca attaagaaac atactattac aaatatagaa
     7021 aataaagctt ttacataatt tttatttcta aatgcaccaa atgacaccaa tccttgttga
     7081 atagctactg taattactaa aagtatcatt attatattaa gttgaaccag tttaaataag
     7141 taaagcaatg aaaacactac tagaagtaca cataatacaa tactagattt attaataata
     7201 tcatcaatct tatctacttt cttagattgc ttattaattt tatttaattt ttctttattt
     7261 aaattctcaa cttttttatt atacctttct cttgttttat ctttatattt agtattttta
     7321 tttttatttc ccatttattt tccatcctct ataaattttt taattgagct tatacattat
     7381 ttaaatatta tatatttaag ataccatata ttcctacaaa aaggtaactt actatgtatc
     7441 tatttttgat tttcgcataa aaaagccatc tcctttagaa ttaattctgt attgagacag
     7501 ctaatttaac tatttatcct ttgaaacatt ttctacatta tcatatttac tatcaactaa
     7561 aactatatca actcttctat tttttgacct accttcttca gatgaatttt ctgctattgg
     7621 tctaaactca ccatatccta cagcagataa tttatctggt gctatacctg cattgtcaat
     7681 aagaagttga acaacattgg ttgctctcat aactgataaa tcccaatttg acttaaactc
     7741 tgaatttttt atagacatat tgtctgtatg gccttctact ctcatgtaac tattcatttc
     7801 atttaacatc ttacctattt gaataatctt atctctagaa ttatccttca caatagcttt
     7861 ccctgtatca aatagtattg tatctttaag gcttattact aatcctctat cttgaactct
     7921 taatgatact gaattagcca taccattttc gtttaaatac ttctgaattt cttcaccaat
     7981 ttttttaaac ttagcatttt gtaaagtatc taaatcatta cttcctggtt caactactgg
     8041 ttctatcttg ctattaccac cttcaataac tccagaagaa ccaccaaaag cagaatttag
     8101 agattgagat aattgtttat atttctccgc atcaacatta ctcatagaat acattattac
     8161 aaagaaaatc ataagtaatg ttatgaggtc tgaataagtt aaaagccatc gctcattgtt
     8221 ttcttctttt tcatcttcat catacaacat aaacattcca tccttttata ttattcagct
     8281 ctaccaccaa tttcttcaag ttcaattagt tcttttgaat ttaaaaatat ttttaatttt
     8341 tctgtcatta aattagaatt atcaccctca agtatggata atattgcttc tatcaccaaa
     8401 agtctttcac ttacttcttg ttgatttata gccttaagtt ttgatgctat tggtaaccat
     8461 attaaattgg cagaaccaac accatacaaa gtagccaaga atgcaacaga aatttgaggt
     8521 cctaatgcat ctggattact tgaaagatta cctaaaatat gtactaatcc cataactgta
     8581 cctattatcc ccagtgtagg tgcatatcca cctgctgaat caaaaattgc tattccttct
     8641 ttatgtcgtt ttgatgttat ctgtatctgt gattccaata tatttcttat agtaactgca
     8701 tccactccat ctaccataag ttcaagccct tttctaataa aagggtctaa ttcatcattc
     8761 tcacttattt ctttgtcaat actaagaagc ccctctttcc tagcctttgt tgcaatttct
     8821 ttgaaataga ttatattttc tatgttatta ggctttttat ttttaaaagc taataacatt
     8881 atctttatag actttttaaa cacagggaat ggagtcgaag ctccaacagc tcctatagtt
     8941 ccaccaaaca caacaagtgc tgatgaaaat acaaataatg ctccaacatg tcccccatca
     9001 ataacaaaag caactaccaa agatgctatc cccactatga aaaaaattaa agttgtcatc
     9061 tattccctcc tttctttagt tatacatatc taatcattta tgacattata aaaagactat
     9121 ctttaataaa aatagccttt aataattggc ggagaaggag ggattcgaac cctcgcaccg
     9181 gttacccagc ctaatccctt agcaggggat cctcttgagc cacttgagta cttctccata
     9241 tctctatact aataaattat ataataaaat catattttag tcaattgttt tataaaattt
     9301 gagttatttt gaattattaa acatctattt ttactttttt gcttaaatgt aagttttaaa
     9361 tatggtaaaa ttatcttgca taacacttat aatattattt gataaatata catacattaa
     9421 caaatatacc taaactctga cttaattgta agttatgcca aaactaaaat aatactagtc
     9481 caaggaggat attttatgtt accacaggaa agatatgaga agattttaag tattctcaaa
     9541 tcagataata taattaaaat aaatgacata gttcaaatgt ttgatatatc aatagaaact
     9601 gcacgaagag atttagccca tatggagagt atcggtcttt taaaaagagt ttatggtggt
     9661 gctataccag ttatagcaag tagcgtagaa cttaactatg ttaaaagaaa aaaaataaac
     9721 tcaaacgata aaaaacagat tgctattaaa tgtagtgagt ttataaatac aaatgatact
     9781 atttttatgg atactggaac tactgtactt gaagtttcaa aaaatttgaa agataaaaag
     9841 aatctaactg taataaccaa ctcaatttta gttgcaaacg aacttatgaa tactaatata
     9901 aaagtatatg tgcttggggg ctatcttaga gaaactgaag gttctttttc tggtccgctt
     9961 acactgtcag ctattgaaca atttaatgtt gataaagcta ttttaggcgc tggaggtatc
    10021 actcttgaaa atggaatctc tgactatcac ttagaagaag cacttgttag aaaaaaaatg
    10081 attgaaaggt ctagaaaatc tatagtagtt gtcgaacctc ctaagtttgg tataaattca
    10141 tttgcatcag tagctcctat agaacatata gatactatta ttacctctgc tagtatagac
    10201 cataatataa taatagagtt ttctcaaaaa ggaatacctt tagtcatagc tgataattag
    10261 cttatatgat tgatttttag ttccttgatg taataaatta aaattaagga gccaaataat
    10321 tatttattta gctccattta tgtctaaact atactttata ttttaattat gtaactactt
    10381 tcagttagct tatcattttt agttatttga ttgccatttt atttaattta taagttttag
    10441 ttattcgatt attttttaat tgtctgtctt tttaatttat ttttagttat ttaaactcct
    10501 actttaaaat aatttaaatt tgacttaagt attgtttatt ctacactgca tctttcttca
    10561 ttttaatact ttgttcttct tccaaggtta aatcttttgt cataagtata gcaagtgcaa
    10621 ttgccaatac tcctccaacc aattttccaa ttacaacagg tgtaatcatc tctggaacta
    10681 ctcctgctgt aaatcctaaa tggtccccca aagctgctgt agcacaaacc agccaagcag
    10741 tatttactac tttccccttt ggactcatat ctttcatcat tttatatact ggaatactat
    10801 tggctaaagt aaaaactaat cctgctgcac tagtggcatc catacctaat tttccaccca
    10861 ctattgtaag tggtttatta agaactttaa ctaataaatg taatattgga aaagtaccta
    10921 ataacacgat tgcaatactt ccaattactt gaataccttc tcttataggt gtcatgcctt
    10981 ttataagtac tatacctgtt atttcttgaa atgctgctgc tcccaaacct atcgttatca
    11041 atatagatat aaattttcca aaaattaatg acccatttat cataagagta gaattaaatt
    11101 ttaaacctac tgccaatatt actgccaata ttatcactgg tatcatattt ataattacca
    11161 ttgataagtt aaatcctgct attaatcctc ctataatacc tccaaagggt attgttatca
    11221 agcctatcag taaccctttt gcaaagaatg gtctgtcttc atattctata agacctagtc
    11281 ctactggaat tgaaaatact aatgtacatc caagcatgga tgacacaacc aatcctgcaa
    11341 gcattcctgc ctctttattg tgtgcaagtt ccatagccaa tggataccct cccatatcat
    11401 tcgctaaaat agttgcaaac atagatgggt cagctccaca gagattgaag attggtatta
    11461 ttataggacc tagtacatct gaaattactg gagctaaaca aactatacca accattccta
    11521 aagccaatgg acccattgaa ttaaaccctt cttcaaactg ctcgccaagt ccaaatttat
    11581 ttccaattat tctatctaac gctcctaaaa gcactcccac agccattatg tataatataa
    11641 ttttatcaaa gggcattttt aattcctcct atacatgtaa aatactctat tgtaacttaa
    11701 ttagcacaca cctttttggt atcgttttcc caattcatag ctctttttac tgcttggttc
    11761 catccaagta atatttcttc tcttttttga gtagtcatat ttggaatata ttttttgctt
    11821 attgtaaatt cacttctaat ttcatcaata ctgttccaga caccacaaga aagacctgcc
    11881 atatatccta ctccaagtac tgtcgtctca ggattttctg caatttcaat tggtatacct
    11941 aatatgtcgg attgaaattg cattgtaaag ttatttttag taattccacc atctactctc
    12001 aacattttta tttttttccc tgaggctaag ttcatagaat caacaacatc tttgacttga
    12061 agtgcaacag actcaagagt cgctcttact atatgctctt ttttagtact tcctgttatc
    12121 ccaaccattg tacctctagc atattggtcc caataaggtg ctgctatacc tgcaaatgct
    12181 ggtacaaaat atacacctcc agtacttgat atggaatttg ccatgtcatc agtttctgaa
    12241 taatttttta taactccaat gccatctcta agccattgta ttgcagcacc tgctatatac
    12301 actccaccat cataagcata tgtaacttta tctcctattt tccaagcaac agttgtcaaa
    12361 ataccattac ctgctatatt tagttcctca cctatattca tatataggaa acatcctgta
    12421 ccataagtat ttttaaccat tcctggttca aaacatccat tgccaaataa agctgctggt
    12481 tggtctacca ttgaagcagt aatttttata gaaaccccac aaaatgcctc cttatctgta
    12541 gttccaaaat caccactcgt aggcattata tctgctaaaa tacttctagg tactcctata
    12601 atgtcaagca actctctatc ccaatccata tctcttatat taaaaagcat tgttcttgct
    12661 gctgtagata catcagttaa aaaagatttt cctcctgtca ttttccatat taaccaacta
    12721 tctaatgttc ctgcaagtac ttctccattt ttaatttttt cttttacacc ttttacatta
    12781 tctattaccc atttaatttt tgtacctgag aaatatgggt ctataattaa cccagtctta
    12841 tctattatct tattttctaa acctggtata ttctttaaat tttccacata atcataagtt
    12901 ctcctgcact gccacacaat agcattgtaa agtggtttac ctgtattttt atcccataac
    12961 attactgttt caccttgatt atctatacca attcctttta tatcactttc attgattcca
    13021 ttttcaaaag cctgttgtaa tacattatta ctcacagttt ttgtattatt ccaaatttct
    13081 atagggtcat gttcaacata tccagattgt ggatatattt gagtatgttc catataatcg
    13141 ctaaaaacaa actctgattt ttcgtttatc aatactgctc ttgttcctgt tgttccttgg
    13201 tcaattgcta atacatattt cactttaaat gtcctccttt attttcagaa ttaataaatt
    13261 cttttttatt ttttgaatat ataatctatt caagttattt atattttata tcatcatgtg
    13321 gatttatgca atattcatta caatattttt tgttattttt aattatagtg attgaaaaag
    13381 tatttttatt gaaatattgt tgcaatattt attattttat tctataatct agttaaaata
    13441 acacataata ttttaatatt tacacataat cagtcattca aaaatttaaa tttaactttt
    13501 taaggaggct ttacaatgaa aaaaacatat ctattcagtc ctggaccagt aatggttaca
    13561 gataaagtca gaaattcact tcttcactat gatatatgcc atagaggaaa tgagtttatg
    13621 gatttattca aagatacaca acaaaaaatc aataaactat ataatgcaac ttctaattac
    13681 tactcattaa ttgtatctgg ctctggaaca tctgtaaatg aatgtgtact atcttctatc
    13741 tttgacaaag aagatgcagt tctgctagtt agtaatggtg tttttggaga aaggctagaa
    13801 gaaatattat ctacttataa tgtaaaaaca tataaaccta attttgaatg ggcagaatac
    13861 ccggacctag acattttaga aaaatacata attgaaaact ctgatataaa agtaattgct
    13921 atggtgttcc atgaaactag ttcaggaatg ataaatccag tccctgaact aggaaaactt
    13981 gctaagaagt ataacaaaat attttttgta gatgcaataa gtgcctcagc aggtgaatat
    14041 attgatgtgg aagagtttaa tatagatata ataacaggtg ttggtggcaa agctcttgga
    14101 gcatttccag gttctgcata cctttgtgct aaagagagta ttttacaaaa tattaaagaa
    14161 aatcaatgta agaatgtgta tcttaatctt tataaacact ataaagttgc taaatcatct
    14221 tctcaaacac caaatacacc taatgttact ttaatatttg cccttaatga agctttaact
    14281 gagtttttgg aagatgacag taaaatagaa agatacaaag aatgttctgc tattttaagg
    14341 tatggtatgg aagaattggg tctaacattt ttacttccag ataagtatat gtctaataca
    14401 gtaacatctg tatttctacc taaagaaatc aatgtaaatg agtttatatt agggctagaa
    14461 agggaaagtg gctatgttgt ctatccagga aaaggcaaat tcctagatgc taacatattc
    14521 caagtagcaa atatgggaga aatatatcca gaagattgtt ataaattctt agatatctta
    14581 aaatcaaaat tggagataaa aaaagttata taacagtttg tttgtaaaat cctacaatat
    14641 atcagtataa attaaataga ctgatttttt taaattttcc tataataaat tatattttat
    14701 atttttgtat aagggtgaac tataatatgt aaagttcacc cctatttcaa atctttttcc
    14761 ttcaatataa tctttttctt ttaatttatt ttatattttt gacgcaatcg ttttttattc
    14821 aatcatttta tattcttgat acaatcattc ttacacttaa ttattttttg tttttgacac
    14881 aatcgttttt tgttgaatca ttttatattc ttgatacaat cattcttaca cttaattatt
    14941 ttttgttttt gacacaatcg ttttttattc agtcatttaa tattttcaac acaatcattc
    15001 ttacattcta ttattgtttg tttttgatac aactgttttt attcagtcat ttaatattct
    15061 caacacaatt accttttcat tcaatcaaag taatctttaa gcattatttt tcaagctcat
    15121 caaagtaatt atatacgata acctcacctg tctctttatc tgtagtcttt ataatgccct
    15181 tagctccatt tacctcttct tttgtaaatt catcatctaa cacaactttg aatttatctt
    15241 cctttccata accttgttga aattcatctc tcaaaattgc atttttttct gcttttggct
    15301 tcaactcaaa ttcaattcca gatttcattt catcaaaata atttaatact acaacctcat
    15361 tattcatttt attagttgtc tttataatcc ctttagctcc atttacttct tcttttgtaa
    15421 attcatcatc caatgttata ttaaatttgt cttcttttcc atattcctct tgaaaatccc
    15481 tcttcatttc attgtattta gtttcaaact ctttactctt gtttaattcc atagctgata
    15541 catttgtcaa tgatgctcca attgccatta ctgttaatgc cattactata ccacttttaa
    15601 atttttttac tttcatatct tacctcctaa attaaatgtt ctcaatgaaa ttatataaag
    15661 aaaatcctaa gttttacagt ttcattcttg taactaaaat tactattatg taaccaaact
    15721 ttttgcttca actattcctt aaaagttgct tttttgagga atagttgaag ttaaataatt
    15781 agattttatc tatatttata gatttaaaat caaatttatc catataaata aatacttatt
    15841 tttgcaaaat aaaaattttt aattactcca atccttctta tttacttaaa atcctatgat
    15901 aagaaattta aaagtcttta ccttctttaa caataattta tttactttta acatacaaaa
    15961 tatagagagt atatcaaaac tattttactg aatattctaa aaataagtac cccctattag
    16021 tatatatatt tacatattaa aaaaaagttt taaataaagt tatatttttt acaacagttt
    16081 tgtaattaaa aacatattga aggtaaattt aaaggtacta tatactataa atatgtcgac
    16141 acaataaatt taaaaaggag aactaaatat gaaaaaaaga ttaataataa tgatattgtc
    16201 tgttgtctta gtactatcaa gtatacttac gatatttgca tattcaaata ttaaatataa
    16261 taataacaaa ttgatatatt ctaatatgat agataaaaaa actcaaaata gtgtaaagga
    16321 aatcctaaaa gaaaataaaa ttaatgaaaa agacatagat acatttatta aatcagtcaa
    16381 caattataat aaattgcaag ttaaaatact tcaaaataat ataaatatat ctaaatctgg
    16441 atattcttca atcaatgcaa aacaagttcc atataaccta gaaaaattgc aagataattg
    16501 ggtgaaaaaa ttccctgatt atatggatgt aaattgtaga ataactgctt ttagactttt
    16561 taaagatttt ataaattcaa ataagaaatt tactggagac tctattgatt tgaatgtcga
    16621 cttggacact ataatgaata ataaagatgc taaatttagc accaaagatg tagaaaaatt
    16681 tatcaacttc ttttctgcaa taccagctaa agatacagat gatacaatca aaattgcaga
    16741 acaaataaaa aatgaatgga aaaaaagaaa aatatctttt aaaaataata aaaatatatc
    16801 tattataaat ggatttcttc gttatccaga aactaaaaat gtatttatag gtcatacagg
    16861 catatgtatt aaaactaaaa atggcattct atttttagaa aaatacggtg ttacatcacc
    16921 ttatcaagtt actaaattta aaaataaaga agatgtaaaa aattatatgt ttaatagatt
    16981 gaagatgtca gaaggtgaaa ttgaattacc tgaccctata ataatggaaa acgataaact
    17041 tatgaaataa taactttaaa cgcaaaatag tatttataat tactaagtca atataataga
    17101 gaaggtctat agatttgtgt aaatacaagc ttatctacaa tcttatataa gaatgtttat
    17161 ataaataaga tagattaatt ctaagtccta ttattctatt gaattttatt attattttat
    17221 ttagattcta ttgttatttt acttagaact tattattatt ttgtttaagt tctattacta
    17281 ttttcaatca tataaattta caaaagactg tacataaatt tattttatac aaacttatct
    17341 acagtctttt gtgtgaatat atctaaataa tatcgtattt atttatttcc tctgcacagt
    17401 gagaatcaga acctaaaact aatggaatat cgtatttttt taccaagtct aataagtatc
    17461 catctatata aggctctttg cagtactctt ttctatttcc agaaacatta taatcaagtt
    17521 cataaccttt ttctttaatt aactttatta actcttcaag aattttattt cctttataat
    17581 cgtatggaaa tacctgatta aactttctaa ctaaatttaa atgacctatt ctttttggtt
    17641 tatgtatacc taaatctgaa tttacagctt ttatcaatgt ttcataatac ttattataaa
    17701 cagcttcaat acttcctaat ttgtcgatta aattttgaaa ctcctctaca ctgtaatcta
    17761 cacaataata atcatcatca atcttaatta tatgtactga taaaagagaa tcctctaatt
    17821 cctttccata tttatttaaa ttctccttta tcccttcttc gtatccttct ataaaatcca
    17881 cttccgaccc aacatttatc ttgattttac cctcatactt ttctttcaac ttcttgacat
    17941 cattaaaata ctttggtaaa tcttcaatac tcatacaact atcattttca ggagcagggt
    18001 ctctaaatcc atttgcatac ggaaaatgtt ctgtaaatgt catttctgtt attccaacat
    18061 ccattgctct ttgtacatat ttttcaaaat catccttact tccatgagga caataaggtg
    18121 aatgtatatg accatctttc ataaataatt cactcctttt ttaaagaaaa aatctaatat
    18181 aaatgcataa atcttttaac ttcaaaataa tatttttaat catgctaatt tttattatat
    18241 ctaatattag agtaatttta aactgccttt taagtatctt atcattagta ctattttcaa
    18301 cttaacatta atattatttt ttaacttaac attaatacta tctttaaata gtaatactca
    18361 atatataatt acttaacata aaataactca aattgcttga tgaggctttt gcagtattta
    18421 aagaatatat aattatttaa cattaaataa tccaatcttg taataaaatt tactcattaa
    18481 agtatattac agaaaatacc tcaaaataaa ctttttagtt catgatatac tcttttttgc
    18541 atgaaattag atatattttt atcatttcaa caatgaaagg gaggcttata tccatcttta
    18601 gacaacccct tagataaaat ttttaataat taaacatcac aaaatataaa aatcgcttat
    18661 atcaaacgta taagcgatta attatattta catatgtttt ttagcctcta acaacatttt
    18721 attagcttct tccatatact ctatagcctt ttcaatactc tttgctgttt cttcttttcc
    18781 aatagctcta gccttttcaa cccactctct aaatccttct tcatgagttt cattgtgatt
    18841 tatccaatgt actaaaagta tttttaaagt tttttcatcc ttagactctg atgattcctc
    18901 atgactatgt tcgtggtcgt ggtcgtgagc atggtcatgt ggatgttcat gacatatatc
    18961 tccatgagta tgttcgtggc agtggtcatg gtcatgatgt ccatgatgat atcttacaat
    19021 ctctttatca aaaatcatta gttattcccc ctgttatttt atattaaact ctttttttat
    19081 aaggtttaca gaatctttta caagtagtgc taatggttta ccttctaatc caactaactc
    19141 cacattttct ggcataatag gtaaaagtat cttaagtgcc tcactgtctg caatagcttc
    19201 acttatatta caagtaactt ctcccatcat agaattaggt attattacag aaataggtgc
    19261 aactattata tttgcttttt tagctgatac tactatagca ttttcccctg tagctccttt
    19321 attagcatga gctttcatca tagaactagt tgctatagaa ttagtcccta gtgcataaat
    19381 ttctacatat gtaggtaact cttctctcaa agaagaaact atctgggctc caatacctcc
    19441 acccattcca tctatcactg ctattatcat atgaaattcc cctattaatt aattttcttg
    19501 tattattatc ttatggtcca tcaatcttat ttctttaatt atcccatcta ttatcttttg
    19561 ctctcctaat aaatccgtta aataaatctt tccatcacaa gggtctatat taaccacatt
    19621 ttccataacc ttttctaact cattattact tttacaaatg aaagctgatg attcacacat
    19681 ataaatctcc tcctaatatg atttttatta aaaatcaaaa aaagattccc ttaggtattt
    19741 caatacacca aagaaacctt catgatttca gtttttgtat attattatac cttaagtata
    19801 tcactttaat ttatgtaaag tcaattaaag ttaacgcttt ttattatact cttcattctt
    19861 gtatttttca tatagttctt taactaattg cttctcataa tcagtcaaat cgccctccac
    19921 aaactcaaca ttaaattgtt cagctaatcc ctttactatg tttttctgta gaatatctat
    19981 gtctattttt ctgccaattt cattttctat tccacttgct tttttagctg taaatttcat
    20041 agctctttct ttcaattctg gtgtcttagt ttttattaat ttaaacaatt tttctacatc
    20101 aaaatccagt attattgaac catgttgtaa taaaacacca tcttttctac tttgagcact
    20161 tccaattacc ttcttattat taatagtaac ttcatatgat gcatgtgcat taaaacatgc
    20221 agctgataaa ttttccctac ttattctctc gcctctattt aaattatctg tttctatacc
    20281 acttagattc aaccctttaa ctagaccttc acttatatat ctataagata ggttgatgct
    20341 cttatcgatt aaaggattat cttctcctat aattatacta taggttagct cattatcatg
    20401 taatacagct cttccacctg taattcttct agtatagtct atattcatac atctacactt
    20461 atctaaatct atctcatctt ccaatttctg aaaatatcct atactcaaac aagctggttc
    20521 ccatgtataa aatctaagag ttggcttatt atgtcctttc ttatatgcag taaatatagc
    20581 ttcgtcaatt gccatattca ttgctccttc atatgattta ttatgtataa ctctccactg
    20641 attcatgatt attacgcctc catttttagt ataaatatat cctagaaatc ctctatagat
    20701 ttatttctct tattgctaaa tctatctcac tttgatttaa aggtcttgaa tagttgtata
    20761 tagtacttcc tggtctttca ttatagtatg gtctattaca atccttacaa cctcttattt
    20821 caaaaggata gcctttgttt atgtctttta aaatatcatt gtcaagcttt atactattta
    20881 agtatccatt tttaaactta aaatactctt ttggataacc tttatttatc atataagaca
    20941 ttaactgtac ccttctataa ctttctatgc ttggttgatt tatcttttcc attttagttc
    21001 ctctaactgg agtaaatgca aataaactaa tcgttacatc attttccttt aaataagtat
    21061 ataaattgta tatatcttca tgactttcac ccataccaac tattatatgt gtacttattt
    21121 tattgggata tgattttgac atttcagtta taaattttaa cttttcatca tagttatttc
    21181 cttttatttt ttcatatagt tctttatttg ctgcatctat tgctattcct attttatcaa
    21241 ctcctgctga aaaaaacttc tttatctgtt catcattttc taattttgca gatagtgaaa
    21301 ttggcatgtc tatcttacca cttatatagt ttataaagtc taaaacagag ttatgtgctt
    21361 cttcacttgc cattgattga atacatattc tctttatatt ttttccttta taagctttta
    21421 aagcatctaa tatttcttct tttgaaaact ctggccaaat tactcttgat aatttatctt
    21481 ttctagtact actttctatt gattgagaac aaaaactgca tttatttatg catttttctc
    21541 caatcattat atatgctgtg gtaggaggta tatcgctttt tttgtttaat atcccaagtt
    21601 ctattgctgt cccaactgat agtctaatca taaaacgcaa cactccttac actcatttat
    21661 tgtcatattc atttctatag ccttattctt tgcagacctt gatggtaata ctattctatt
    21721 gactccacac attatagata attggtctag ctcttttcta tacactcctc ttggtctcat
    21781 acaacctaga ttaatttcag tatctggtaa attaattcta gcttcacata aaatatctgc
    21841 taccccttct aactcaggag gttctacatt ttcatactca gtcccttttg ttggaataag
    21901 gactataaat gtaagcttat taggaggatt tttttgtagg tattctataa tttcatattc
    21961 accctttatt tgtcctcctt ttaaaccaat acatatatgt ggtgctactt ctgtatgttc
    22021 ttgtattgta ttatagactt caatataatc ttctttactc tttttcatct tataaacttc
    22081 tcttattgtc tcatcatcaa acactaaatc aaaagaaact atatctaaat acttacacaa
    22141 ctctacaatg ctatctttat ccataagacc taaatgagca ttcaatctat atccttgctc
    22201 ttttaagttt ttaatggtat taatatgagt atttataggg acatctccct cataactaca
    22261 accgccactc aatagaaagc tagttatatt ccttgattgt actttttcct catattcttc
    22321 tattggcacc atattgttta agtagtgacc gttgcaatgg gcacatttca aactacattg
    22381 attgcttgta gtactaagag ctagtgtctg gttaggataa gcaaactcta ttttatttcc
    22441 aaaattcttt aatttaatat caaatgctat tttcattttt tcagatagat tcttattcat
    22501 agtttattcc ttcttaagta cattttactc ttctagtaat ttctttgctg ttgggaactg
    22561 ctctatattc gtatgtggta agaaacatgc agaaataaat tcatccatat aacttggata
    22621 tacactaagt tcaacataag ttatttgatt acctatttct tcaagtttat tttttgcatc
    22681 tttacttata agcgctaagt aagaaccaac aagtgaacta ttccctatat aagtaaattt
    22741 ttctctatca atatcaggaa gtaaccctat aattattgag ttttctatgt ctaggttgtt
    22801 tcctatacca cctgctatat aaaccctatc taatatacta aaatccatac ctaaactatc
    22861 tacaagagtg tatgcgcctg aatatatagc tcctttagct ctgatgaaat tatctatatc
    22921 aacttcattg actactatat cattttctaa atcaaattct tctttaaatg ctaatacata
    22981 ctctcctatc tcatgctcat taaatctaac tctcttatta tctaaatccc tgtatatttt
    23041 acctcttcta tctattacac ctttagtaat catttgacag attaaatcaa ttataccaga
    23101 accacatata ccaactggtg cacattcatc aataatcttt aatgttggct ctaaagtatc
    23161 tttatcaata attactttct ctattgctcc tgctgatgct ctcattccac agcttatccc
    23221 tccaccttca aaagcaggtc ctgctgaaca tgcacagctc atcatataat ctttatttcc
    23281 aaatacaatc tctccattag ttcctaaatc tataaataaa acattttctt cacttgacca
    23341 tatccctgct gataatacac ctgctgttat atctcctcct acataacttg caacagatgg
    23401 agctaagtac acatatgcac tgtcatttac aaaaagacca acattttcac ccataagttt
    23461 tggagatttt aaaaatggtg gtatgtaagg ttcttgtctt aagaagtctg tatacacacc
    23521 caagaataaa cttgtcatag ttgtatttcc ggcagccact aatgtaacta catcttcctt
    23581 atctattcca tttctttcat atattgtttt taatagtgga tttatagttt cctcaactat
    23641 agctttatga agtgtctcta atccattttt cttagttgaa tatataattc tatttataac
    23701 atctgctcca tattttatct gtgcatttcc agaagatgct ttatctacta cctcttttga
    23761 gtataggtct actaaacaaa caactactga agttgtacca atatctattg caactccgta
    23821 taaggaattt tctttatttc cttgttctat atttatgatt gtaagtttct tttgtttttg
    23881 aacatatgtt attgtaacct taaaatcact ctttctaaat acagttggca tttttctaag
    23941 tatatccaat ctaaaatcta tttcattata tcctaggtta tttctaacat atctttccaa
    24001 tctatctaca tcacttatat tatcatctaa atttggttct tccatttcta tgtatttctt
    24061 ttttatattt gttttaaatt gaaggttatg ttcttcaatt atttttttag ctctttcaaa
    24121 aatttcccta tcctcttttt tattactacc ttctatcttc ataccatgca tagaagatga
    24181 tactttagaa ggaacttcaa tttctatatc tgatattacc tttgtacaac aagctagtat
    24241 ataaccttgc tcccactcat catctgttat atgtcttgtt ttttctgtat caacttttcc
    24301 attcaataat tttactttac acttcccaca agacacgttt ccattacaag gagcatctat
    24361 gaatatatct gcatttcttg caacctctag taatatatcc ccctcattac aataaacctc
    24421 tttattgttt ggtgtaaaac ttacttttat catgttatcc ctcccaattt gttctatata
    24481 tgataaaagg aaagtatagc taaatttgcg tgcactcaaa ttttactata ctttccccaa
    24541 ttataataat atcttaatct ttaattattc taatccagcc tcgtattctt tatcacttaa
    24601 taacgtatca agttcagcca catcagctag ttttactttt aatatccagt tttcatatgg
    24661 gtcttcattt atacattctg gctcatcttc taatttttca ttaacttcca atacctcacc
    24721 attaacagga gatattaaat cagaagctac tttagaagac tcaactactc caaaatctac
    24781 tcccttagtt acagtatctt ctacttctgg tgtttcaaca aacaatattt ctcctaattg
    24841 atcttgagca tagtctgtta tacctatata tacaacatct ccatcaatta cttttaccca
    24901 ctcatgatct ttagagtatt ttaattctgg taataatttc atttcgatag acccccaata
    24961 ttatattatt gattaaatta cttaaatcat attaatatta tatcatatta ttttaaattt
    25021 tccatcaatt acattacact ttccatagct aatgctggat gacctttttc ttctaagaaa
    25081 gctaatactc cttcagaatc gtcagctata gtttcatcac aaaccatatc acagaagttt
    25141 tctattccag tcatttcttt aactgtagca tttaatttat cagctacata atcttttaat
    25201 tcttttggca tccaaactat tctttctggt ccaccttctg cataagcgaa ttttttagaa
    25261 gatataaaat gtcttccgtg tcccataaat cctggagttt gaactcctcc acctgtcata
    25321 gaagcaagtt ctccgaaagt cataccaact ggagtaacac ttgcaaattc tctgttaact
    25381 acaacaaatc catttgcttc tggcattata ccacagatac attcgaagca tccacaagaa
    25441 gtcattgggt cttctagtat agagtataat gtaacagatt caactgcacc ttgagatatt
    25501 tggtttacag tttcatttac tgaattccat acacctgttc tatcatctaa gcactcgcct
    25561 ttttctattg gttgacaagg acctgttggg tctaattctt tagtagcctt agcatctaac
    25621 cagctaactg ctccacaaag accaagtctt tcaggagtaa caacacaaac gtgagctggt
    25681 gcaaatgatt gacataagtt acaagaatag aaagtatcaa cactttcatc aactaatgaa
    25741 gctaatcttt catctctagc attgtactta gctattgctt ctccttttaa ttcagaaact
    25801 ttttcagcat ctgtaattat agttatttca cacttatcaa ctactgattc aaattcatct
    25861 aacatcttag catataaaac ttctcctata tgctcaagtc taaatccttt atcaaatgca
    25921 tctttagaga ttcttaccca agccatatct ctttgtccaa cgtgcattac accttctata
    25981 tagtttaaga agtagtggaa acgtctttca agaactggct cgaaatcttc ttgcatattt
    26041 ttaccagcta ttttaactat tacagcaagt ggtaatctta atacaccatc tgcatcaact
    26101 tcatctatat ttggccctat tatttctatc ttatggtctt caacttctgt tgcttctttc
    26161 ttaacaacaa gctcccaagc ttcagttctg tttccaccaa actcagcaaa catatcgctc
    26221 tttctaattc tctcaccttc aaatgctgct gcaaatgaaa ctgggatagg tatttcagta
    26281 acttttattt ttattcctct agcttctaat gaagtagcta ctatcttatc gtaatctttt
    26341 tgagttaata ggttcattgg aacttcaaga actgtttggt cagttataac tgggaatcct
    26401 aaagctattg ctccagcacc tgcagataca actaattcac ttaatggtcc aaatgcatta
    26461 acaaatgcag gaactctatt agctgtgtac tctaataatc cgtttaaatc accaggagtt
    26521 aatccaccga atattaatgc tgctcttact gcaacagata caacgtgtat aacagaagtt
    26581 acatcatatc ctagaggtat aactcttagc tcaagaccca tttttactcc agcttctata
    26641 gcttggtcta taactttacc aactaagaaa gttagtaaac ctttagattg gtaatctttt
    26701 ataacttttg ctgctgattc tgcatctgga cactcaccaa gaacaactgc aacaccaggt
    26761 atatctcctg taactaatgg tacaccaagt gatctgatta tagggtcagt tatatgacct
    26821 gcacatggct cactatatgg agcatccata gttgaatatt ttaatgcttc aattacttct
    26881 gctgctaaag ctgtagctaa accagcatta aaagcatgtt ctagtaaatg agttctattt
    26941 attaaagatt ttactacttc taaagcacct tctaagtccc ctaaagtgtt catcttttgt
    27001 cctgttgcag catatataca aggtaatgaa tatgctgtat cagggaaagc aactttatgc
    27061 tcttttccat tcttttctat agcttcagct aacatagctt gagccgcacc taaagcttgt
    27121 tctgaccctg taaagattat attatataga ttcattctat ttcccccttt aatatttaca
    27181 cctatttttt attaactata ccctaaaaac cctagaaagc aaatccacct tcatttaact
    27241 ctaagaaaga gtctgcatat aaagatgccc cgttgattat gtcacaagat tttacagttt
    27301 tcattaattc tgggtcacat ggattcatta tagctgaact aaatccatta gccattgcca
    27361 ttgctaagaa tgcactatct aaaacaggtc taacatgctt aggacatcca ttagatacgt
    27421 tagataatcc tcctgtagtt aaaagtccca tctcagtcat catttttata gcttctaaaa
    27481 cttctacttg tttttcttgc atacctttta taactaagca taatgggtca aatagtatat
    27541 cagttggctc cattcctaac attaagcctt tttctaatat ttcttggcag taagccatac
    27601 gctcatcatt atctcttggg ataccttctt ttgcacataa acctataacc attgcttcgt
    27661 attcagctgc tatatctatt aaatcaaatc ttgagccagc atcagcagag tttattattg
    27721 gttttgcatt agttctatca taaactttaa gtccagcttc gatagctttt ttattagctg
    27781 tatctaatgc tataggaaca ttgttgaact cagattgaag taatttgatt ccccatgtca
    27841 ttatttcttc gccatctctt tcggcaggtc ctatattaaa atctatatag tgtgctcctg
    27901 cttctaattg ctcttttgct ctttttaaga ttggagctgg gtctctttct gctaatgctt
    27961 ttcttattga aggtgatata caatgtattc tctcacctat aatcataaat ttttccattt
    28021 ataatgtccc cctttaaatt taatattaat agttagttaa tattttatta gtttgtttgg
    28081 catgcttttt cttggtatcc ttttaagaac ttaggtaatt ccatagattc ctctggtcct
    28141 ataactacat tccatcctgg taagttatct tctatatcac ctttaagtac tgcaactttt
    28201 cctggaatga taaggtcttt acaattagtt acttcttcta ccttactttc tttaatgaaa
    28261 gcagagattg agtttccacc aaatttacca gcagcccaag atgtaagaac tgaatatcca
    28321 cctgcatctg gtattactaa ccatactgga acttttgatc tttctatatc accagcaact
    28381 atgaagtaag ttaatgcaaa gtcaacagta actaatactg gagaattttc atctggattg
    28441 ttgattggat aaatctttgg ttcaactctc attggtcttt gtgggtcagt gtatatgttt
    28501 tgtcttagtg caaataatgg taatgcctta gcataactaa tatcatctat tactattata
    28561 gaaccgtatt ttatagtgaa tattgatgat aaagcaactt ccatcatagg gtttgaatta
    28621 gataatctat ttgcaaatac tattgaagga tatccaaatg ttctatcttg ctcttttaaa
    28681 gctgttcttc taacttgtat agcattagtg taagtatctt ttatgttttc tcctgttaca
    28741 tctaatacta attctttata tccagcggct tgaattaatt caactgtttc atataattct
    28801 tctaagctac cagcttttac acctaatggt aaacttgctc ctttaactac ttctatcata
    28861 tctttgtagt tctctttagt tgctccatat accattggtc tagcatcttt taatacttca
    28921 acagcttctt taactacttg tgcatcatca caagctaaaa tataagctac ttctaatcca
    28981 ctgcctttta ttttatctat taattttaaa tacgcatctt tatctccaca atactctaaa
    29041 acagccattt caactttcat ttgttcacca attcttacat agtcaacttt tttcatgtta
    29101 gctattttag catctactgc ttcatcactc atacaagtac agaatgaaac tgcatatcta
    29161 tttctactta ctaatgtttt ttcatgtcta aataatactg tttctccacc tagttcatac
    29221 tcagatgcac cagcaccaac ttttaaagct ttcattaaag gtgcagtagc ctctgataat
    29281 tttgctatag cgtcatcaga catatgtggg catttaccta cttctacagc tcctgaagca
    29341 accttcatag agaaagccat acaagttggg aatccacaat ccttacagtt tttctttggt
    29401 gttaatttaa atatatctaa agcttttaat gccattattt tttcccccta accttaacaa
    29461 tttaattaag ctaatgcgtt aaccaattct tttatagttt ctattgattt tggatgacga
    29521 agtataactg cgtttgaacc acctactaaa acacttgctg cagttgaaac ttccattgct
    29581 atagttcttt cttctggaca accccaatct ggctcatctt ctattggagc tatagcttct
    29641 ttaacatgac ctacttcaaa agctactggt gttatgatag gcatttgtaa tgtcttatca
    29701 ttttgaccaa atgctgcaag tctaattcta tccatagtag atgcaacgta ctcatatcca
    29761 taaccaactg ctgaacatcc aacattcata actatatttt cacctttaac gcctagttga
    29821 gttaacaata cgtttaattg tttagctagg tttatatcaa cagaagattc agctcctact
    29881 ttatgtgcat aagccatacc agctgatgct cctactcctt tgtagttatc ttctactgct
    29941 gacataaata agcagttatg tccatccaat gtttgagcta atttttcaaa taatttacca
    30001 tctttttcat gatttcctga accagctaca actaaaggta attttattgc ttcaattact
    30061 gccttagcta catcagcaca ttcatcaact gacttatcta atccatttgg gtcagaacca
    30121 tcaaatttta aacaaataaa atctgcttgt gtattagctt caacatattt agcccactct
    30181 actggacaat tagctacatc tttgtataat tccttatatg aatcagtcca gctttcagga
    30241 taaacgtctg atatttgtat acctattttt ggagaattac ctacttctcc atcaaaacta
    30301 taaaaaggta atacattttc cccacctaat ttaattgctt tttcccctat tcctacttca
    30361 acttctgata tttttccaga atatttttga gtagacattt taaatgccat atttttttcc
    30421 cccttaagcc tattttaatt ctaatttagc aaaaatttct ttcatagcca ctttagattt
    30481 tgaatcttca ggtaaattaa ctaaaggaat acctgtagaa tcatattcat atatcaattc
    30541 atccataggt acaacaccga ttagctctag gttatgcttt tcaatttctt ctttaacacc
    30601 atcattcata accccatttg gaactttatt tacaatcaaa agtattcttc caacacttaa
    30661 ctttagttcc tcagctaaat ctcttattct agcaacagct tgtatgctac gtcttgagca
    30721 atcactaacc aataaaagtg tatcaacatg tctagtgact tttctactta gatgttccat
    30781 accagcttcg ttgtccatga ctaagtattt gtaatgacca gatattttgt ttacttgttc
    30841 tctaagtatc ccatttacaa aacagtaaca tccttcacct tctgacctac ccattactaa
    30901 taagtcatat ccttcgcctt cttcgattat agaatttaat ctaaattgaa gatattgtgc
    30961 ctttgtcata ccaccaggga atgcattgcc taacttttct ctttgattta cttcttctct
    31021 tatttctcct attgttgctt caacttcgat acctaacact tcatttatgt tagcattggc
    31081 atcagcatct acaactaata ctggtccctt tttgtcctta accaaataat caatcaaaag
    31141 ccctgtgaga cttgttttac cagttccacc ttttcctgca acagctatat tgtatcccat
    31201 tttaagactt cccccttaaa tctagccaca gagccttatg tactctgtct gtctattata
    31261 atttaggtac agaatgaaca cattctccat gtacatcatg aagtgcttcc attagccctt
    31321 cagataaact tggatgtgga tgtattgcat cccctacttg ttctactgtt aatcctagat
    31381 gaacagcaag tgacaactct gtcaataaat ctgtagcatg aggtcctact actgctgcac
    31441 ctattatctt atcagtttct ttgtcagcta taacttttac aaatccttgg aaatgtccta
    31501 tagcttgtgc ttttccaaga cctctaaaat caaattgacc tacattgtat tctacacctt
    31561 cagcttcaag ttgcttttca gtcttaccaa caccagcaac ttcaggttca gtataaacac
    31621 atcttggaat tgctctataa tctactacct tagtcttacc taaagcattt tcaactgcta
    31681 cgataccttc tttagaagca acatgtgcta ggaaaggagt atctattata tcgcctattg
    31741 cgtatatacc ttctacatta gtttcaagat gttcattaac tactactttt cctctttcca
    31801 tttcaattcc tatatcttct actccagaat tgtcaaggtt aggtcttcta ccaacacata
    31861 ctaatgcata ttgtgcttct ataacctttc cattagaaag agttgcaaca gccttaccat
    31921 caactacttc acaagtttgt actccaatac ctgtaataac cttaatttta tctttcttaa
    31981 attgtctaag tagttgttta gctacatctt tgtcttcatt taatagtatt tggtcaacca
    32041 tctcaactat agttacttct gttcctaagg ctctaaagaa ctgccctatc tcacatccta
    32101 taactccacc acctactatt aacatagact caggtatctc ttcaagtcca agaacttcat
    32161 cactagttat tacaactttt ccatcatatg ggaacattct tggtacaact ggaacagaac
    32221 catttgctag tattatctta tctgctttta tagtttctac tgttccatca tctttagtta
    32281 cttctatagt gtttttatca attaattttc caaaaccatt aactaagttt actcctcttt
    32341 tttcaaataa gaactctata ccacttatta attggtttac aactttattt tttctttcca
    32401 ttatggcagt gaagtttggc ttaattgtac catctatttc tataccaaaa tcctttgctt
    32461 cttttacagt attcaatact cctgaagaag caagaagtgc tttagttggt atacatcctg
    32521 catttaagca agttcctcca actcttcttt tttcaacaac tgttacatct gcaccaagca
    32581 tagaagcttt tatagctgct acatatcctc ctggtccacc acctactact actatcttca
    32641 tctttaattc ccccaaacct aatataatct acaatcttgc aatactataa acctgcggca
    32701 tccagtatag caggtatatt ctcttctgcc ccaattgcca ttatatgaac accatcacat
    32761 aaatcttctt cttttaattg tttgataagt tcccctgcca tttttattcc ttcacttacc
    32821 cagttttctt ttccagctgc tcttaatctt tcgatttgtt catctggaac aaatattcct
    32881 ggtacatttg cagtcataaa tttagccatt cctggtgatt ttaaaggtac tattcctgct
    32941 aataccttgc aatccatatc ccttgttaat tctctaaact ttctcattgt atttatgtca
    33001 taaagtgctt gtgtttggaa aaatttagcc cctgctttta ttttcttttt catttttaat
    33061 aattgaactt ctattggaga atattctgga gttactgatg ctcctagata aaaatctgga
    33121 gaacctttta acttattacc agccatgtcc gtacctgcca ttaaagtctc agcagtttga
    33181 agtatcccca cagaatctaa atcaaacact cccttagctt gtggatggtc tcctacgcta
    33241 gtatggtctc ctgttagtgc caacagattg tttatcccaa atacacctgc tgacaacatt
    33301 tctccttgta tagctattct atttctatct ctccctgtta tttgaataac tggctctaat
    33361 ccagcatctt ttaataattt acatgtagca agagaagttg ctctcataac tgccgattga
    33421 aagtctgtta catttgctgc atgaactctt ccaactaacg gctttgcaca ttctattaaa
    33481 tgtgaaaggt cagtcccttt tggaggagcc atttcagtag taactgcaaa ttttccactt
    33541 tctaatgttt ctcttaataa gctcatctct aatccccctt ttaaccttct aaaaaaactt
    33601 ttatgaattt gctgctgctt ctttcttttt ctttgcactt aaacttcttg gattattttg
    33661 cttagaatag tcttttggtg gtcttatttc tgctaagtta tctaattgtc ctatagcttc
    33721 tagtctttca tatatcttta tccaagcaca atcattctct gagtttactt cacacttacc
    33781 atttttagct ccaccacaag ccccattcat aagaccttta gcacacatag ttactggaca
    33841 tatcccacct gtccaaccaa gttcacagtc tccacaagcc ttacaggctt cttcatattc
    33901 tccaactctt tgtacttccc ctataaacaa agtattgttg gctggataaa ctggcttatc
    33961 ttttaaattc ttaactattg tctgtgtacc atctccacat gctaaagata aaactgcatc
    34021 agcttcctta gtctcttctt ttagagcctt taaatccttt ttagacttta aaaggttaca
    34081 agcagggtca agcattacat atcctaagat ttttttgcct tcaccttcaa gagtttcctt
    34141 catttttaaa acttcttctt ccccaccact tttacaagtt gctgcacatt gattacaacc
    34201 aactaaaacc agcttgtcaa aatcttttaa gtaccctagc acttcttcta atggtttatt
    34261 ttcagaaatt atcatatcta cttcccccct aaaccttcca catatatata tctatttatt
    34321 gttttgtaat ttgcaagcct taactacatg ttttgcaagt atagatgttg taactgaacc
    34381 aacccccgct ggaactggag ttatcattga tactttgtct aaaactgcat ttgtatcaac
    34441 atctccacat aaatttcctt cttcatcaac atttatacca acgtctataa ctaccgctcc
    34501 atctttaaca aaactttcat caaccatctt agctctacca atagctgcta ttagcacgtc
    34561 tgcctctgct gctacacctg atagattttt agtttttgaa tgacatattg taacagttgc
    34621 gtgttcactt aataaaagca ttgatactgg ctttccaact accattgatc ttccaagaac
    34681 tgttacctta cttcctttta aatcaacatt atagtgtttt aatatctcaa ctactgctgt
    34741 aggtgtacat ggtggaaatc cacttttatc cccttccatt accttagcag agtttattgg
    34801 actaaaacaa tctacgtctt tttccggtgc aataacatat tttataactt cttcatttaa
    34861 gtgttttgga agaggtctaa aacataatat accattaaca tttttgtcat cattaactct
    34921 ctttaataca tcaatatatt cctcttgtgt tatatcctca gctaactcta acacttctgt
    34981 tgttatacct atgttttgac atctctttag tgctcctctt tcataagata aatcatcact
    35041 tcttgcccca actctaacta ttgttagttt aggatttata ccttctttaa ttagtaaatc
    35101 gacttctttt attaattctt cactaatctt atcagctaca ggttttcctt ttataatttg
    35161 tcctttagtt gacattcctt ccatacattc acaactcccc tacaagcaaa cttaaattaa
    35221 tttattctat ataccacata ttaataacat agtatctact ttcgtcattt aaaaattatt
    35281 ttccaagagc tttttcaact ttggcataaa cttcatcaca aatttttaca ccatcttcaa
    35341 ctaacttatc tacttctgtt tttaccttat taacatattc tttatcttgt atagaattta
    35401 tatttataac tacatttaat tgtccaccaa gtatagcagc tcttaaacac tgaactccta
    35461 caccaacatc acttatagca agtcttgaac ctttatcaac taaatcttca tgtaacttaa
    35521 tagcttcata gcaaactctt actatgttta atggtacttc acaagcaact tttaatgcct
    35581 tttccattgt ttctgctttt attctttttt cttcttctgt ttctttagga agcccgtaag
    35641 cttttgataa tggtaagaaa cattctgcat catcatctat catttttaat aaatcttttt
    35701 ctaactttcc tgccttactt aatatctctt ttacactttc ttcatactca gcatacttct
    35761 tcttccctat tgtaaggtta cataccatac tacctaaagc catacctatt gcacctacta
    35821 gtgcagcagc tcccccacca cctggtactg cttctttgga agatagtact tctacaaaat
    35881 caacacaagt tttatctgct attttcatga taatcctcct tgaaaggatg taggaaaata
    35941 tctcaaattg ttcgagatat tttacgaact attttaagat atctcctact ctttatttat
    36001 aaattaattt ccttagaata atccagctat tactccattt tcatcaacat ctattttttc
    36061 tgctgctgga acttttggta atcctggcat cttcattatt tctccagtaa gtgcaactat
    36121 aaatccagct cctgctgaaa ttgttgcttg tcttacagtt attctaaatc ctgttggtct
    36181 acctaattta gtttggtcat cagttaaaga atattgagtc ttagccatac atactggaac
    36241 tttagtaaat ccaagttttt ctaagttagc tatttcctta tcagcttcag gagtataatc
    36301 tacaccatct gctccataaa tcttagtagc tatagcattt atcttgtctt ttatagataa
    36361 atcatcttca tagcagaatc taaagttatt ttcttcttca tccaataatc ttaaaacttc
    36421 tttagctact gcaattccac cttctccacc ttttgcccat acttcagaaa gagcaacatt
    36481 aacacctaat tccttacact tgtcttcaac aagtttaagt tcagcttcag tatcaagtgg
    36541 gaatctgttg attgcaacaa ctgctggtaa tccatatact tgagttatgt tttcaacatg
    36601 ttttaataag tttggaagtc ctttttcaag agcttctagg ttttcgttat ttaagtctgc
    36661 tttagcaact ccaccattgt attttaatgc tcttacagta gcaactatta taacagcatc
    36721 tggttttaag tttgccattc tacattttat atctaagaat ttttctgctc caaggtcagc
    36781 accgaaacca gcctcagtta ttacataatc tgcaaagtgc atagccattc ttgtagctat
    36841 aacagagtta catccatgag ctatatttgc gaatggtcca ccgtgtacaa atgatggtgt
    36901 tccttcaaga gtttgaacta ggtttggttt taaagcatct tttaataatg cagccatagc
    36961 accattagct tttaattgtc tagctgttac aggttcacct tcgtagctgt atccaactat
    37021 tatgtttcct aatctttctt ttaaatcaga tatatcactt gccaaacaga acgctgccat
    37081 tatttcagaa gcaacagtta tatcgaatcc atcttgtcta actgctccat cacctttttt
    37141 acccatacca tcaacgatat ttctaagttg tctatcgttc atgtctacac atcttctcca
    37201 agttattttc ttagggtcta ttctaagtgc atttccttgg tgaatatggt tatcaagcat
    37261 agcagctaaa agattgttag cagctcctat agcgtgaaaa tctcctgtga agtgtaagtt
    37321 tatatcttcc ataggaacaa cttgtgcata tcctccacca gctgctccac ctttaacacc
    37381 aaatactggt cctagagatg gttctcttaa agcaactaat acatttttgt ctagtttagc
    37441 aaatgcatca gcaacaccta tagtagtagt agtttttcct tcacctgctg gagttgggtt
    37501 tatagctgta gttagtatta acttagcttt tttaccagtc tctcttttta gtagattgta
    37561 gtcaactttt gctttgtatt taccataaag ttctacatca tcttcaccta gtcctaattt
    37621 ttttgcaacc tctctaatat cttgaggctt agcttcttga gctatttcaa tgtcagattt
    37681 aaatcccata actgaatctc ctcccacaac ctaaatagat ttaaaatata atttttgtaa
    37741 aaattgtatt aatatgtaaa aattatattt tataagataa ttatacatgt aaaattactt
    37801 aaaaactagc tactaagcta ttaaaatatt caaacttaat agctagttat ttatctaatt
    37861 acttacttat tacctatcta ttgcctatgt ctaaccttta accaacttaa aatcccaaat
    37921 caaaatttct atctatttta tttatcctta agtgacatta atttatcttt tattgcttta
    37981 atctgttctt tcgttgtttc actagaatca tatggagatt gattagctct atcagaatca
    38041 ataacatctt ggttataata aataaatcct aaagattctc catcttctaa gttttggatt
    38101 ataaattctt catcttcctt atttctaatt ttatttccta ctacaaatac tttatttaca
    38161 cctatatcat gtccaagttt cttaactttt ctataagtct gtagacttct ctctcctggt
    38221 tctacaacta ctataaaagc atctacacct tgggctgttc ctcttcctaa gtgttcaatt
    38281 cccgcttcca tatccataac cactacatct ttattttgta gtattaaatg tgagcagagt
    38341 ctcttcaaaa gaacatgctc tggacataca catccagtac caccagaatc tacggttccc
    38401 aatgtaagta atcttactcc attgtattct ttacagaaat tttcagggat atcgtctact
    38461 ttaggattca tcttaaacat ttttccaaat gaacctacag aagcagctgt tctatctgaa
    38521 actaattttt tcatttctga tataggtact attgattcat atacttcttt tggaaaacct
    38581 agtgctaaag ctaaattagc atcagggtcg gcatcaacag caacaactct gtatccgtct
    38641 tcagcaaaca tcctagagag cattgaagaa aaagtcgttt tacctactcc acctttacct
    38701 gttattgcta tcttcataat ccctaccacc ttttattact atttgctttt tagtagttaa
    38761 ttttacagtt aaatattttt tatactctat atttttatac actaaaaata aactacagct
    38821 agtccttaca ggaaccaatt aaatttaccc tactagcttt tcaaagcagc atgtatagtt
    38881 ttattattct ttaatattgt ttatatttta tttattcagt atattcatta tattttgatg
    38941 ttctttactt taatatttga ctttattcaa ctttattcaa ccagaaactt cttataaaaa
    39001 cgtttattct ataacttcac tattttttaa gcttcagcct tttctgccat cttttcttca
    39061 actaatgctt caaagtgaac acgttttttc tctatatctt ctattattgt agctgctaac
    39121 tcttttggat ttgtatttac agtaaatgta gctccaactt tatcttttaa ttcactagtt
    39181 aatatatcca ctgctcttga agaaccagct attggaggca ttattcctaa ataagtgtct
    39241 ataccagaag ctacaacata gcatcctata gcaactgctt tttctgacat ccactctgga
    39301 gctataccta caactggaag gtcacacata tccatatcta agtaattagc tgctgctcca
    39361 actaaatcta gtatacgact tatatcaaca caagaaccca tatgtagtac tggtgggatt
    39421 cctactaatt tacagacagt tgcaagacct ttacctgcat atttttcagc cgcatcagat
    39481 tccattaaac caaacttagc tgctgctgaa gctccacaac ctgtagtaac tactattatg
    39541 tcgtttttga ttaattcttt cattattgtt acgtgagcct catttgaaac tcctttagca
    39601 ttgttacatc caactacacc agctgctcct cttaatactc cagattttaa acagtctgtt
    39661 aatggcttaa ctgttcctgc tgggtctata tgagagttta caactctgtc taattgattt
    39721 actactgctt ctacactata cccaactgtt gcgcctgatt ttaattcagg tataagtact
    39781 tttgatttat ctctattttt aaagtttaaa atagcttctt taactattgc tttagcatca
    39841 tcaagtgctt gttcttctct aaattcaata taagttgaac ctgttatctt agcttttgga
    39901 gaagttgtta caaatttagt atggtaacaa tctgcaactc tagctaatgc agggaatata
    39961 cattgaacgt caactattac agcttcaact gctccagtta ttattgcaag ttcttgttga
    40021 tggaagtctc ctgctatttt tacaccatgt ctcattgtaa tctcattacc tgtacaacac
    40081 atacctgcta agtttattcc atcagcacca acttctttag ctaaagctac taagtctggc
    40141 tcttctgatg ctaaaactat catttctgat aatgctggct catgtccatg taatattatg
    40201 ttaactttat tttcttctaa tactgctaaa ttcgcctctg ttcttcttgg cactggagtt
    40261 ccaaataaga tatcgcttag acgagtacct atcatagaac caccccaacc atcagccata
    40321 gaagttctaa gactcatgtg tattaaacta tctatatcac cagtacatcc tatatgagta
    40381 gagtgcatta ttgttgcaat ttctctatct atagctcttg gctctatagc gtattctttc
    40441 catatttttt gtcttggttc tggtgcattt tttataaatc ttaatgtccc aaaaggtttt
    40501 ccaaattcca ttaatgcaat ttctgccact tcatgtgcta catcatagat atctctacct
    40561 tctgtctcta catcccattc tttagctaaa gtaattaact tagcttcgtc tcttatttta
    40621 tagtttccat ttggatcagc taatgctaat gtatgtgcta tatctctagc atggtctgaa
    40681 tgggcagctg tcccaccagc aaccattctt gcaaagtttc tacctactat agtatgctca
    40741 tctgctccac ataaccccct tggagtctta gggcttattc tacatggtcc cattccacat
    40801 attctacagc aaacaccttg aagaccaaaa ccacattgtg ccttaaagcc ttcttttcta
    40861 tcatacattg tttctacgcc ttcttctcta gctttagcta tcatcttctg gctgtttaaa
    40921 tcaattgtta acattttttc atccatattc ctatcccctt tttttgattt ttaaaatccc
    40981 ccaggtgact gacttcatgt cataaaataa taaaataaat gctttctaag ttgattatat
    41041 actaattttc agtgctttgc tttagattta aatatttttt taacaaaatt agataataca
    41101 taaaaatttt attttctaca cttaatttaa gttgatttta tcgcttgttt ttggctattt
    41161 gttaatatct aaacctactt ttttgatact tcagtttaat taaattatgt tttgattttt
    41221 ttaaatcaaa tttgaaattt ttctagtcat ttttatatta ttgcagattg tttgtgtatt
    41281 tattatcttt cactactgtt tggacttatt acagattttt actccctaaa cttaattagt
    41341 aaaaacttct tagaatagca ttttttggac taattttttt gaattttttt atttttccta
    41401 ctttaatatt aattatagct tcaaattgaa catttgtata tattcatttg aagctataat
    41461 tattttttat ataaaacttt tttaatacag cattaattta gacattttga ctattttttc
    41521 tactttaatt catttatttc aagcgattta tcctatttca tatttttagc tacaatagcc
    41581 ccatatgcaa tagaatataa tttagattca tgtgaatcag ctcttgacac taaaactata
    41641 ggagcttttg cacccataat tatacctgct gatttagagt ctgccatata tgtaaaggct
    41701 ttccctattc cattaccaac ctctattgtt ggaaccaata tgatatctac atctccagat
    41761 acttcacttt taaacccttt tatctcacta gcttcttttg aaacagctaa atcaaaagcc
    41821 agaggacctt ctacaattac attttcacca aattctcctt ctttacaagc ttttgctaac
    41881 atatctgcat ctacagttgc ttgcatctta ggatttactt tctctttagc tgccaaacat
    41941 gcaactttta cagtttccat tcctaaagct tttgcagctt ttatagaatt ttttaatatc
    42001 tttgcctttt gttcataatc aggagctata ttcatacctc catctgtagt tataagtaat
    42061 ttatggtatt tttctaactc atataccata acatgactta ataaactatc agttctaaga
    42121 ccatagtctt tatttaacac ttcttttaat atgacagatg tatctaataa tcctttcatt
    42181 acaaagtcgg cttctttact tgatactaat ttaactgcta tttctgcaca ctctttgata
    42241 tcatccttat ccactatttt gataccactt aaatcaaatc ctatttcttt tgatatttct
    42301 cttattttgc cttcatttcc aaccaatata ggagtaatta tatttctttc tacagcatcc
    42361 tttattgcca ttaaaacttc tttatcatga gctgctgcta cagagagtac aattttctct
    42421 cctcccttaa gttgttctaa aatatcatct aattttttta tcaaaagtaa cccctccctt
    42481 atatatattt aactaaataa taccatattt gctatacctt ttctcaattt attttttatg
    42541 ttataaagaa tttatataac taaaagacag tttaatattt tattctggga tttcatcaat
    42601 aactcttaaa agctttgcag gaacaccacc tacaatagta ttttctgcaa cattttttgt
    42661 tacaactgct ccagcagcga taattgcatt atctccaata gtaactcctg gaactacagt
    42721 tacattagca ccaatccata cattttttcc tattgtgatt ggagaaggat aagttgtacc
    42781 acgtttctct ggtgcaatac catggttaag tgtagccaat accacattat gcccaatttg
    42841 cgtattatct ccaatctcaa tccccccctg gtcttgaaaa tggcaactgc tatttataaa
    42901 aacatttttt cctattgtga tgttttttcc acaatctgta taaaatggtg gaaacataaa
    42961 aaatgattca tctacctttt ttccaattaa ctcagaaaat aaactacgga cttcttctgg
    43021 ttcatgataa gaagaattta acttacttgt gattttcatt gcttcattac tcaacttaac
    43081 cataaattca tgtatttctg atttactaga aacaggtttt ctttgattga tatgtgttaa
    43141 aaattcattg atattcattt tatacatcct ttcaatatgt gctttaattt atttgtacat
    43201 tctaaataat attttaataa aaattaattt aatttatttt tattaaaata tcattgcttc
    43261 ttttagtgta atatacaatt atatctatat caaatatcta tagtaaatac ttaactatac
    43321 ttaaaaagca tataaattga tataattata taatagataa gttaatattg aggagggata
    43381 attatggaaa taagagtatt aagatatttt ttagcaattg caagagaaga aagtatatct
    43441 ggtgcggcaa cctttttaca tataacacaa ccaacacttt ctagacaaat tatggaactt
    43501 gaagaagagt tgggagttaa attattggtt cgaggaaata gaaaaatcac cttaacaaat
    43561 gaaggtaggc ttttacataa aagagcagaa gaaattatat cattagttga taaggttgaa
    43621 ttagaatttg acaatcccaa tgagattatt agtggtgata tatatatagg aagtggtgaa
    43681 actgaagcta tgcgacttat agctagaact gcccatcatt ttcatcaaaa ataccccaat
    43741 gtaagatatc acctttttag tgggaatgct gatgatgtga ctgaaaaatt agacaaggga
    43801 ctgcttgatt ttggtatttt aattgaacct gcaaatatac agaagtatga ttatgcacaa
    43861 attcctgcta ctgatgtatg gggtttacta atgcgtaaag atagtgccct tgcatcacaa
    43921 agcacaataa atccaaaaga tttatgcaat atacctctta ttatttcaag acagacactt
    43981 gttgataaag caatttctaa atggcttcaa gacagtaatg aaaaactaaa cattattgca
    44041 acatacaatt tagtttataa cgcttctctt ttggtagaag aaggtctggg ctacgctctg
    44101 tgtttagata gactcgtcaa tactacagaa aacagtaatc tttgttttag acctctatct
    44161 cctcctttag aagctaaatt aaatattata tggaaaaaac atcaaatatt ttcaaaggca
    44221 gcagaaaaat ttttacttca aatacaaaaa gatttttctt ctatcatgtt ggatacatct
    44281 aagttggata cacctaaaga aaaataaatc ataataaaag gtgagagtgt ctcaaaatga
    44341 actttgcact gtataaggca ctctttttta tacaaagtaa aatatatgtt catcatttca
    44401 gcactaaaaa agaggcttat ctctattttg agatagcccc acttaaccaa taaaattaaa
    44461 tacaacttaa caatatcctt acttatttat tctaagttct cttagacaag caatagtaat
    44521 ttcatcttgt ggatttaatt cataagctct ttctatatag taagttgcat catcaatatc
    44581 accattattt aaataagcca ttcctaaatt gcaaagtatt tctgggtctt cctttatctt
    44641 agccgcttgt tcaaaatact ctattgcttt atctaaatta ttcttataag cctcacaaag
    44701 ccccaattcc actatagtat ccacttgatt aggctttatt atcaatatct tctcaagata
    44761 catcttagcc tgctctattt cgcccatacc cttatatcca agtgctatca taaacagcaa
    44821 gttccaccaa tccatatgtt cttcttctaa tggaagtaac ttctctaatc cttccttaaa
    44881 cttaccttgg aatacaagtg tatatccttc ttcatattga actttaaagt ccatcttgcc
    44941 cagattctct tgtacctcag ctactaaatc agcatctaac cctagcctta acgcttcttc
    45001 ccaagtcagc ttagtcttta aatattgacc ttgattataa taatggtagc ctaagtgata
    45061 ataacctaat gcaaaattct catcaacatc aattaccttt tcaagcttag ccatggcttc
    45121 aagtaagaat gcattcattg ccttatcatc catatctttt tgatactgtt tagctatctc
    45181 ttggcaaaca atcgcatagt tatacattgc atctaaatca tctggataca ttgttataaa
    45241 tgcttttata tatattaaag aatctgtatg ttcaccaatc tcaaagtatt ttctcgacat
    45301 atatcccata tacgatttca aatccaaatc aatatctttt gataaagcat ttaaaaactt
    45361 ctcatactct gcattgtttt taaacttact atctattcca attatatata tcattgcatc
    45421 tgctatagac attgaattta acttatcttg agcagtcttt tcttttatcc cttttactaa
    45481 tacctcattt tttataggta catctaatcc accttttggc acttcatagc tttttaattt
    45541 aaactctcca ccatgtttta tagttataaa agctaattct tctgcttttt ttagcaaata
    45601 tttttctatc ttaaaatcca ttttatcctc ctaaatactt aaatctctac tttatgagtt
    45661 ttagatttct caaatatttt tttatcatca tactcaaata agactacatt ttctacttct
    45721 cttatttctg tatttatatc attttttaaa tccacaacat taaatctaaa tggctcaaaa
    45781 tgaacatatt ttattatatg tttagctggt ttatcaacaa aactaggtaa atatgttgat
    45841 aagttatcat tatcttgtaa aaatacatgg catctattct taaaatcatc cacatctagc
    45901 ttattaaaaa actgtggtat atttgatgtt ttacccagtg atatatagtc atattttaat
    45961 atatcgttga atacatcatt atctatgttg attttttcat tatagaaatc catcaatatt
    46021 ttatataact gattctttcc ttgtgccaaa tcaaagtagc cattttcatc aaaatacttg
    46081 gcaaaaacct caaagaattt aaaagggctt tttttataaa atctgcctat aatatatctc
    46141 atagataaca caaagttttt agaattgtag tatctctcca gtatatcttc tatatccttt
    46201 agcttcaaag tttcttcata gcttatataa ttattgtata aaaactcata tggagcataa
    46261 tccttatatt taaaaccatg ctcatctgca acttttctca tacctgtccc tttaatcatc
    46321 tttaaaaagc ctaattgcaa atgctctata cctagattaa atacatcatt aaaagaattt
    46381 tcaaagctct tataatcttc ataaggcagt cctgcaatta agtctaagtg ctgatgtata
    46441 tttctataag atgctacagt ttgtacaaca tgagacaact ttttaaaatc atcccttcta
    46501 cctactgcat caagtgtttt ttcattcgtt gactgaacac ctatttcaaa ttgaaaaaga
    46561 ccttctttac aatcagccaa aaactcaagc atcttatcat ctatcaaata cgctgtaact
    46621 tcaaaatggt aagttgtata tccattatca tttttcataa ggaaatccat gatttccata
    46681 gccacttttc tatttgcatt gaatgtccta tctataaact ttatctgtga tactcttgca
    46741 tctattaaag cttttaaatc actctttatc ctgtctaaac taaaatacct tagacctgga
    46801 atagtagatg ataaacagta ttggcagtta aaagggcaac ctcttgatga ttcataatac
    46861 actattctat tttcatattc ttttggattc aagttttcat aaggactagg aatctcatcc
    46921 aaatcttgaa gtaattccat aggcttattc actattatct cattgccttg tctatataca
    46981 agtccattta catcatttat ttccatcttt ccttgcaagt gaagtactaa gtctctaaaa
    47041 attaattctc cctctccata aagtatataa tccacaaaat catacttttt cattgcctca
    47101 taactatcat aactcacttc cggtccgccc aaagctattt tagtattagg tctaattttt
    47161 tttagattat cacaaagttt aactatatct cccacattcc agatatatgt tgagaataat
    47221 attatatcat attcattttt atatatatcc tttaaaatat agtccaaatc gttatttatc
    47281 gtgtattctt tcatattaac ttctatcaaa tctcttacaa attcttttag atatcttata
    47341 gccaaatttg tatgaataaa cttggaattt aatgttgtta ataaaatttt caaatatttc
    47401 tcacctcttt ttaagattat actgtctttt tgtacccctt ataggttaaa atagtatatg
    47461 taaagtctaa ataatatcta tataattaat ttattaattt caagtaatgt gaggaaagga
    47521 agttttttat ggaattaatt gaaaaagtat ctatcaactc tttatcaaaa agagatttac
    47581 tacttattat aaagtctctt gaatacacta atgaaaatac tcaaattagt gatttcattg
    47641 accttaggaa taatatagta aaggaattat gttttttaac tgacactaag gaaaaagatt
    47701 ttttagatta tctagaaaaa aatagcacac tctaataacc taaacctttt taaactttaa
    47761 tatataaata cctgatttag aatttatttt tatgcttaat atattatcat taaaggtttt
    47821 cgacataact gttatttgat taaatatagg gtctattata gtattacctt cttcaagtct
    47881 tataagactt cttgggtcta tgcttttatt atatgcctta actccaattt tatattttct
    47941 caatttaaca acatattcgg acatagaaaa aataaaatct atattatctt catttaattt
    48001 actatcttca cccaaaatgg ataatataga tttttttatg ctattaattc cttcattttc
    48061 tacagttcta tcttccatat atacatcata tagaacattt aaaacattta ataaaatact
    48121 ttcttcatca taatcttcag atttcaaatc aatgtactta tcaattaatt gtattgcttt
    48181 aatccttgcc atctgaaact ttacaacatc tgatttgtct aattctatag aaaatcctat
    48241 tatcttgtct ttaatactct gtagtaattc gacatactct attttactat tatttataag
    48301 attgtgcata atggaattat acaccacaga acctaataaa taatcaaata aaagttcttc
    48361 ttttttaaaa taaataacat acttttttat tagtttaata acctcatctt cacttttttg
    48421 aatattagta tttgataaaa ttagtggtaa taaaatattt aaaaaattga tatttcctat
    48481 tttttctcca taaaatctat agtaaataag ttcatctctc agtctatttt cgtctatata
    48541 cacacatctt tgcgttttat catctattaa ggattttgta tttattatag ttaaatcttt
    48601 aagagcccta cttgcactac taaaagaaga tgtgtagact ttttttagta attcgtcatt
    48661 cataaatata tcctttctga aaaattgaat gtaaataaat tgttattaaa aaaaaagaga
    48721 cagcccgttt aagaagctgt catatatagg gggatagtag tgtacaaaaa tcattgtaat
    48781 ctactatcta tatattatta tacgatacta cttttttata tgtaaagcat cagttttcga
    48841 catccctata ttttacagtt atacaaattg cgtactaagt tcaattttat tctttttatt
    48901 tcaacatttt atcatgctac attctttcag gagcgtgcat tcccaacaat ttcagagaat
    48961 tttctaaagt ttgttttgtt gctaaaacta atgcaagtct tgcttttctt atttccaaat
    49021 tttctactaa aattggattg tcatgataaa atttattaaa cgcttgagct aaatctagca
    49081 taaatctagt cactatatgt ggctcatttt tctttagagc aagtaaaata ttcttattga
    49141 atgattctat aactctaaga acttctgcac tatcttcatc agctaataga ctataatcta
    49201 tatcagaagt cacttctact tctgcttttc ttaaaactgc acagcatcta gcatgtgtat
    49261 actgaacata tggtccagtc tcaccatcaa aactaagcgt tctttcccaa gagaaggtat
    49321 agtctttaat tctactatta gataactctt ggaatactac tgccccaaca cctacttgct
    49381 tagatatttc atccacattt ttagcatttg ggtttttagc tagtataatt tccttagttt
    49441 tatctatagc ttgatttaaa gcatcttcta aaaatactac tcttcctttt ctagtcgaca
    49501 tagtaccttc ttcaagtgca accataccaa atccaacatg aattaaatct tttgcccaat
    49561 catatcccat aagctcaatt accttaaacc attgttggaa atgtaagttt tgttgagaac
    49621 caactacata tatacacttg tcaaaatcat aagtttcttt tctatatatt gcagcagcta
    49681 aatctcttgt catatataac gttgagccat cattcttagt aataagtgct ggtggcattt
    49741 tatactcttc taaatcaaca attcttgctc ctttagactc ttttaaaaga tttttctctt
    49801 ctaatagttc gataactctg ttcattttat cagaataaaa actctctcct gctaaagaat
    49861 caaattctat atctaaaagt ttatacactc tgttaaactc ttttaaactc tcatttctaa
    49921 accattgcca taattcttgt gcttcttcgt caccattttc taatttatta aaccatgctc
    49981 ttgcttcatc ttccatttct gggtgttgtt cagcttcatc atggaatctt acgtataatt
    50041 ttagtaattc tggaattgga ttagactcta ctacttcttt ttctccccac tttttaaagg
    50101 ccactattaa cttaccaaac tgagttccat agtcacctaa atgatttatt cttatagtct
    50161 tgtatccttg cgaatcatat atcttatata aagcattacc tataactgta gttcttatgt
    50221 gccctatatg gaaaggtttt gctatatttg gagaagaata ttcaactatt acagttttat
    50281 cttttccaaa atcactatgt ccgtaatttt ctttttcatc taaaactttt ttaattacag
    50341 tttctgctaa ttgagattta tttacaaaga aatttacata tccgcctaat tgtattactt
    50401 ttgttatctc tccacttggt tctatacttt ccgccaattc acttgctatc atgtttggag
    50461 cttttctaaa cactttggct aatttaaagc atggaaaagc atagtccccc atatccttat
    50521 ttggtggaac ttctataagt gcctctatct cttctttcga taaatcttct attttttctt
    50581 taaggcaatt tgatattgcc accttaaaat cttgcattct gttgctcctc tctacattgt
    50641 tcctggttta tattgtgctt atctctttat gttaaatcaa atttcgtgtt ttttcaagta
    50701 tttcattaca gtgtaaaaca ctttagtaat tatgttttct gtatatatta aaaatactat
    50761 aattgcagtt tttaatcaca ctattattga ttttttataa gacttttttc tattttattg
    50821 tttcttgtac tatccagttg actttatata ctttttttaa tcttttatct attttcatac
    50881 gtcaatgcta attttatata cttttctttt aatcttttat taatttttat acatcaatgt
    50941 taactttata taagtttttt taatctttta tctgttttca tacatcaatg tcagctttat
    51001 atactttttt tactttttta tctattttta tacatcaata ttagctttat atactttttt
    51061 taatctttta tctattttct ataaatcttt ttcactctta acttttattc cttcttcttc
    51121 taatagcctt gctgttatac ctttccctgg tatcttttta cctgaaaaac taccatcata
    51181 tattagatta catccacaag aggggctacc ctcttttagt attgcttcgc tacatacata
    51241 taaatttgct atttttagag tttcattagc ccctcttaca aagttttctg ttacatcctt
    51301 attatcttta gtaattactt ttccatcaac tatctcagca ggtggtcttg gtgtagatag
    51361 accacctaac tgctctgggc atacaagtgt aaattctttg ccttttaaat attccttgac
    51421 tttttcatta tcattattat cgccactata tttacaattt attcctatta aacatgcaga
    51481 taccaatatc ataaaaatgt gctcctatac aaattcttaa tatattctca tacaaattac
    51541 taatgtattc ttatacaaat tattttaatt taacaattgt tactcctgct ccaccttctc
    51601 catattgacc acctctttgt gattttacat gtctatttct tcttaaaatg tcttgtagcc
    51661 ctgcttttaa tactcctgta cctattccat gtattactgt tacagactct aaacctgcca
    51721 catatgcatc atcaagatac ttttctactt ccattatagc ttcttctagg tttaaccctc
    51781 taaggtcaac ttcatttttt acactaccag attttgacct tataatgttt ctcgttgatt
    51841 tagttacatt tgttgaaaca tctttgcgtg ttttttgtaa agacttaaaa ggtagagtca
    51901 tcttcattat accaatttgc actactgctt cttttctctt tttatctact gaaactacac
    51961 taccattttg atttaaagtt attaccttaa cttcttcacc tggctttaag tcttttatct
    52021 ccttatttga tacctttgga actatcatac tttttactgt tggctgaaga cttcccatag
    52081 agctggtcaa ttcttttcta agttcttcta tcttacgatt cttttctttt gaagctcttt
    52141 cttgttcaag acttctaagt tcttttatta taatatctac ttcttcttta gcttgtctta
    52201 taattgaaaa tgcttctgat ttagcttttt caatcatctt atctctttga ctgaccaatt
    52261 tttcaagctt ttcgtcatac tctactttca gtttttcaat ctcttctttt aatctttcag
    52321 cttcttctct atcttctact gctttgattc tattcttttc aacattctgt aacacatctt
    52381 ctaaagctat gttttctgta tttatatatt ctttagcacg tgaaatcaca taatcactta
    52441 gcccaagttt tctagaaatc tcaaacgcat ttgattttcc gggaacacct ataagtaact
    52501 tatatgttgg gcttaaagtt tctatatcaa attcaactgc tgcattttct acacctggtt
    52561 tagtaagagc ataattttta agctcactat agtgagtggt agctatacat ttagctccta
    52621 cagaatttat atcttctaat actgctattg caagggcagc tccttcaaca gggtctgttc
    52681 ccgctcctaa ctcgtcaaat ataactaaag agtctgctgt tacgttttgt aatatagata
    52741 ctatattcgt catatgagat gaaaatgttg atagactctg ttcaatactc tgctcatctc
    52801 ctatatctgc aaatacatta tcatatacac acatactact tccataatca gcaggtatat
    52861 gaagtccact ttgtgtcata agtgcaaata gacctacagt ttttattgta acagtcttac
    52921 cacctgtgtt tggacctgtt atcaccaatg tatggaagtc tcttcctaaa taaattgtat
    52981 ttgctactac cttcttttta tccagcagtg gatgtcttcc attttttatg tttaaatatt
    53041 tatcctcatt taaagttggt tctattcctc tcatctgtat agaaagtttt ccctttgaaa
    53101 atgcaaagtc caatcttcca agtatctctt gattagaaat taagtcttca ctaacttctc
    53161 caaccatagc agaaagctct gataaaattc tttctatttc ttcttgctca cctagtttta
    53221 actgtctcaa ttcattgttc atctctacta tagtcattgg ctctataaaa agtgtcgcac
    53281 cagaagatga ctggtcatgc actataccag ctacttgcga cctatattca gattttacag
    53341 gtactacaaa tctatcacct cttagagaaa ttattgcatc ttgtaagtac ttttgataag
    53401 tagttgaact tattattgaa tttaattttg acctaatgga ttgatttttt tgggctattc
    53461 ttcttctgat atctctaagt gtacttgaag cattgtcaga tatttctact tcactaatta
    53521 tagcattgta tatctggtct tctatgtcct tgtatacata tagagaattt gatagagatt
    53581 gtattattgg ataattaaaa tcttcttcat cactactaga taagctattt cttaatcttc
    53641 tagccactct taaggtatct gctatcataa tcagacttcc tgggtcaaga gaagcaccta
    53701 tataagctct ctttacctta tcttctatat catgaatacc ttccaaccct actgaacctc
    53761 tctttataat aattgattga gcttcactag tttcttctag catagatttc acttctacaa
    53821 aatcagtatt tggtactaaa ttttctatat attttagacc taaagaagat gaggctttct
    53881 tctttaacaa atctattatt ttattgtatt ctagaactct taacgatttc tcattcattt
    53941 tctatattca ccatcctcga tattttaact tttttattta attttaaaaa tgtatgtttt
    54001 caagcatttc caataaaaac tgcaagtttt atttcttttt catttctaaa attattatat
    54061 tttttctctt ttagatatat tttacacata ttttgtatta tactatgtat gtagctatct
    54121 atatattata cataaacatg ctttatttgt aatataatct gttaaaaaat cttctttaat
    54181 atttttaaag gagtttattt tagcttataa aaaaaaatag ctacttatat agataaatta
    54241 aggaggaaca tgagtcatgg gaaacgtatt agaaggatta aaaccagaaa gtgtttttaa
    54301 aaactttgag aaaatatctc aaattcctag aggttctgga aatgaaaaag gcataagtga
    54361 ttttttactt agctttggta aaaatttagg tcttgaaact attcaggatg aaagcttaaa
    54421 cataataata agaaagcctg ctacaaaagg atatgaaaat tgtccaggtg tagttcttca
    54481 aggacatatg gatatggttt gcgaaaaaga aaagaatgtt gaacatgatt ttcttaaaga
    54541 ccctataaaa ttaagaattg atggtgacat gatatatgct actggaacta ctctaggagc
    54601 tgacaatggt atagctgttg ctatgggtat ggctatatta gaagataata ctttagagca
    54661 tcctgcacta gaagttttag ttactgttaa tgaagaagat ggtatgaatg gtgcagatgc
    54721 actagaccct agcttaatta aaggtcaata tatcctaaat atggactccg aggaggaagg
    54781 atacttatta gttagctgtg ctggtggtaa aacttgtgtt gttagtttac ctgttgaata
    54841 caaggaagtt aaaggtgaca aacaaggatt attagttgag gttactggac tattaggtgg
    54901 acactctggt atggaaattg ttttacaaag agcaaatgct aacaaagcaa tagctagagt
    54961 attaagtgta ttgaatgttg attatgaatt agcttctgtt gatggtggta ctaagcacaa
    55021 tgctatacct cgtgaagcta aatgtgtaat agctgttaat aaagctgatg ttgaatctgc
    55081 taaaaaacaa ataaatgaca ttttaactgc atttaaacat gagtttacta cttctgaccc
    55141 tggcatgact tactcagtag ctgaaacttc tgtagacaaa gttcttacta aagattgtaa
    55201 agaaaaagtt gttcaaatgt cttgcttaac tcctcatgga gttcaatcag taagtcttga
    55261 tatagaagga ttagttgaaa gttctactaa cttcgctata atcgaaacta aagaatctac
    55321 tattgaattt ttaacttctg ttagaagttc tgttatgtct attagagatg aaatcgctga
    55381 tagaataaga cttttggctc aagctttagg tgctaattac gaccttatag ctcaataccc
    55441 agcttgggaa tttaaaaaag gctcaaaatt agaaaaaata tgcagtgaaa cttatgagaa
    55501 attaactggt aaagttccta ctgttatggc tctacatgct ggtcttgagt gtggattatt
    55561 acttgataaa cttcctcatg ctgaagctat ctctatagga ccagatatgt ttgatgttca
    55621 tactccaaat gaacatgtta gtatcccttc tgtagctaat gtttgggatt atgttattga
    55681 aatattaaaa tctatgaacc aatattaaat ttaagttttg attctaagta gattttaatt
    55741 ttaagtaatc tatataaaat taactctgta aattaatact actgttagta taatatttac
    55801 tttcaatatt aacttataga aataaagcct aatgatagat aataacatgt atcattaggc
    55861 tttattgtaa tttaaatatt attaagcttt attctgtttt aaaattaatt cttatactat
    55921 tttaaatcta tttcttcctt gtctcttaga atcataaaga gcattatctg ctatttgata
    55981 cagttcatca tactcttgac caggctttgc tataactacc cccatactaa tagataaact
    56041 ttctccattt ggcaacttaa tgagatgaat atgattgtat acatcattac atttattaat
    56101 aagttcttcc ttatttatta tatcattgat ataaacacta aattcatctc cacccaaacg
    56161 acctactata tcattttttg caaaactttc atcaagtacc tttgcaacat caataagtac
    56221 tttatctcct aacaagtgac cataagtatc attaatcgac ttaaaataat caatatctat
    56281 aatcaataaa gcaccatttt tttcagttga taaattcaac aaattttgtg cagttaattt
    56341 tctaatatat gctgcattat aaatattggt taaactatcc ctttgagcct tatctaacaa
    56401 tctattcttt tcctcttttt cagaatcaat attacatatt ttcccgatta catacattgg
    56461 tatttttcta tcattataaa ttatttttga agtaactcta atccaatgaa aagtatcatc
    56521 aagcataata gaatacattt cagttgttcc attttcttgt gattttatta catcaaaaaa
    56581 ctttttatta tattctttcc ttattttatc tctttcattt tctatattgc cattttcact
    56641 ttccttatca tttttatcca aaccataata agtctcaata cccttttctg gcatagaaat
    56701 tatcaattta tcttgcttat aatcatactc aaaaaagtat tcacttgtca tttcatacaa
    56761 ctgagtatgt tttttgagtt ctaaagatat cttctcgttc atacttgtac gagtatgcaa
    56821 accaaatgcc ataaatccaa taatacaaat taataaactg gctacaataa aaatagtctc
    56881 aattggattc tgttgcataa tataaagcaa cgagaagtct tgtctatatg tagtattttg
    56941 gtagacaatt gattgcattt tttctgatga aatacttata atagctttat taaatatatt
    57001 caataattct tgtttatctt ttttaattat accaaaacaa atactctttg ctttataagt
    57061 ttgaggaact agacgcacat ttttatactt aggttgattc atatagtact gcatagaata
    57121 accttcgcca taagtgtaat ctgcatagcc tttattaaca gcttctatac actcttctaa
    57181 attatcatac caaactatat tctcttcaaa ctgaccataa taattaatac ctttggctag
    57241 agctacacgt tttccatcta aactattctc atttaattta ttattaatca tcatagtata
    57301 ttgagtagaa agaaaaggcc gagacataac tatattatgt tcacgagagt attcataatc
    57361 ataaatcatt cctgctacaa tatcaatttc acgcttttta gtcatgtttt ctaaatcttc
    57421 ttgagatttt acaggcacaa gttcaaattc taagcctgtt ttatcacata tatgatttaa
    57481 caaatcaatt gatatacctc ttaattcacc tgtatcttta tctatatttt gaaatggtgg
    57541 tttgtttaaa agtactccta cttttaattt ttctgtctct ttaatgtaat cagtttcttc
    57601 atcagataaa aacatttgat tgttctctgg tgtaaagtat ttttcatata aagtagttga
    57661 aaaatatggg tctttctgtt caatattatt aattgctgag ttaagctttt gagttaaatt
    57721 tgtactacct ttaggagtaa tgaaataaaa tggttttgat gaaaattttg ctacagtacg
    57781 tacaccttct agtgggttca tactaacatt aagaagtaca tctgctttac cactctttag
    57841 tgcttctagt tgctcatcat ttgttttaca atataccaat tcaggtgaca taagattcat
    57901 tttacaatac tcatctaact ctttaagtct agtatcagaa ttttctatta cagcaatacg
    57961 gatttttttc acatcttgtg aactcattat gttatcaata tctgtatttt catataatgc
    58021 ttgtagtact gtatttgcta ctccataact atttcctgca taattatata ttttttgcat
    58081 tggctcattg tataacatac ctcccattat atcaatttca ccattttcta acatcttcat
    58141 taattttgta atagattcat ttatctctcc aggaacttga acaaattcat aattccatcc
    58201 agtatactgt gcaatttcta gtaaatattc atatgtatac ccaaaatagt taccttgctc
    58261 atctatttca gttaaacctt tttgaatagg ataagcaaca cgaatggtac gattatcatt
    58321 acctatagcg ttgataccaa aagaaaatat gcaagaagtg aatatagatg taattacaat
    58381 aattaataaa agtaattttt ttaaattcac tacacaatcc tccatatagt taagatttac
    58441 agtataaatt actgcataaa cttgtagaca tgtaaaaata gattagtata taaaaggata
    58501 tataaatcta cttagaaatt taaatatcct taatatatac aatatattta aattataact
    58561 catttatatg tctattacaa caaatttacc ctgctaaata cctactctat atcccataat
    58621 tttacaagtt gtagtgaagt ttaagttcta tctcacctca aatttagcag tgtttctatt
    58681 tacagttctt ttatatttca catctggata acccaatata aatgaagtga taacagcttc
    58741 gttctcgctc attcctaaca gttcttttat ctttggctct acatttgatg ccataacaaa
    58801 aaatccatta taacaaattc ctaatccttg agaatatgcc ataagttcca tattagatgc
    58861 agccagtcct ccatctacat aagcacttcc acctagagac atatctccta caactaccat
    58921 aagtagtggg gcatcataaa ataaagaatc atttccgttc tctttatatc ttttgtacat
    58981 tttcttaaat gtatttttat agatagaacg tacagggtca ttgtcatcag tatctaatgc
    59041 caaattataa agaccttgta ttgccagttc tttcacttct tttagctttt cttttactaa
    59101 tatgtatctt ataggctgtc tattaccacc tgttggtgtg tatctaccag cttccactat
    59161 gttttttatt ttttcttctt ctacctctat atctttatat tgtcttatac ttcttctaaa
    59221 tttaataaaa ttcaataact tttcgggttc taattcaaaa ctttcacgat tgtattctat
    59281 tacttcattt ttatcaaatc cttgcatttc tattgcatct gttgggcaaa ttgccataca
    59341 gtgaccacag ttaatacaga gaatattttt aacctttgct ttatcatcct taacttttat
    59401 tgcatttaca agacagtctg attcacacat cccacagcct acacattttt ctaaatttat
    59461 gtctatcatt ccaaattatt cctcctttta aaaaatttac tttagtataa aacaaatagt
    59521 tgtctaagtc aatttttatt tttttaacaa tatactagcc ttaactacac tttaatggag
    59581 aaaaatatac ataaattgga acttaaatta gaacttattc aaagtaaaag ataaaagaag
    59641 tagatgtcta aaagtgaact ttttagttaa ttagatattc tttattgtat gaaatcaagt
    59701 ggatatttat catttcaaca ataaaaaagg cttacctcta ttttggatat gtccctgtca
    59761 agtagacaga ctaaaaaaag gctatcttta tgcactgaga tagccccttt tcccaactac
    59821 tattgtttat cttaatatta gtcaataaat ttaatttgct ataacctgta agttacattt
    59881 taatttgatg taactttaaa ttacattttt aagtaatatc tttaaattat attcttaaaa
    59941 tatatcatta aactacattt taattaatct aaaaactata tcttaattaa tctaagaaac
    60001 ttacattata atcttttagt ttcccattat catatacaat ctttgcacta aagatatttc
    60061 cagtcttagc ccaatttaag aacagcctgt caccttccca catatttaaa tcgaatattt
    60121 tatcattatc aacccaaatt aaatttcctt ctttacaatc atttaaatct ttttcagata
    60181 attcaccttc aaactcatct gagaaataca aaaacatata ccaatcttct tcatctttaa
    60241 attttggaaa agttatcaac cctttatatg acaatgattt aagagtaaga ccagtctctt
    60301 cttttacttc tctaattaca cattcttctg gagtctctcc ttgctcaaac tttcctccaa
    60361 ctcctacata cttaccttca tgtatatcat ctttcttttt atttctgtac aacatcaaag
    60421 tcttgtcatc tttttctata taacaaatag ttgtaagttt catgtatctc gccttgcttt
    60481 ctctttatat tctcaactaa ttattttcag cactttcaag cacatcactt atattcttca
    60541 ttgcattaag agaaagctct gcaaattcat caaatggaat ccctatatct tctatacttc
    60601 tcattgcatc tctatttaca tttgaagcaa atctcgtttc tttcattctt ttaataacag
    60661 acttagtctt tacactggta agttttttat ctggataaac taaagctata gcagttataa
    60721 acccagttat agggtctgct gcatatattg ctttttccat taggctagtt cttgtaactc
    60781 ccattccatc atgatgacca agtattgctc tatacatttc ttcgtcaccg aagttttctt
    60841 ttttaagcag ttctactgtt gttgtagcat gtccctcaca tatttctcct ggctttcttc
    60901 caactatatc tgaatccaaa tcatgtaaaa gacctgccac tgcccactct tcttcttttt
    60961 ctggctctag tcttttggct aattctctca taacagcttc aacagcataa caatgttttc
    61021 tcattctatc agtttctaaa tacttaaata aaatttctaa agcttcttct ctcattttca
    61081 ccaatccccc tgttttttca catatatgat atttttatat attaatacac ataaattcaa
    61141 gtttttatat atattcatgt atatttttca tgttatatct attctacacc tttatagtag
    61201 tgtcctgcaa ctgttccaat ttcatctaat ttcttataca agtctgtagc cctttttcca
    61261 agtttataat tattactcaa tacctcaatg tgagcttcaa taaccttttt aaccatctca
    61321 ctatcttcaa ctgtaaaatc tatcctaaat acatctattc caatttcctc taactcatat
    61381 agattgtcca acatacaagt aaccttcgaa ttgtaaattg tacttctaca gaatatatct
    61441 tgtgttatcc tataacttgc atccgtaaag tctcttaaag cataactact ttccttacat
    61501 ttagcaactc tcttgtcctt tttacaatcc ctaacaacta ctcccatagg acagtattct
    61561 gtaaccatca taggagcata tccatatatt actgcttcaa tttctacatc tgtatatttt
    61621 aaagtttgtt taatttcatt taagtttagt tcttgtgaca aacaaactgt acttgctccc
    61681 tcttctttga agtggtttat actttcacta ttgaatgcat ttaagtagca atctatattt
    61741 aagtcttttt tcttaaagta ttccatagag ccccagttac caatttgaac cttattaatt
    61801 ccttttatat tatccaatat ctcaaattgc ttgtactctt tatttctaac aatccttggt
    61861 gctgaataga ttaatttttt gtcagtgact gctgtattag agtggttctt attcaaagta
    61921 tctattttac ttgtatttga caaagtatat atgttatttg tatttgaacc cattagttct
    61981 ttaggaatac ctaaagatga agaagtatat aaatccatag aaatacttga atctatagaa
    62041 atacttgaga ccatttgtaa agcttttgat aatgtattta tatcttcata atagattaaa
    62101 tctacattat aatttaatac tgcttctaat tgctccaagt tcttaacttt aactctaatc
    62161 ttaggaactg tatcaagttt tttctgttta tttactctat ttggctggta ttttaatcta
    62221 ttcttcttaa attttctatc ttttatcttt attctttctt catctaaaag ctcaatacaa
    62281 tcccttctca tctgatttaa cacacttata ggcatactta caccttcatc caggtcaatt
    62341 tctatctctt ttaacttata tggtgtattt ccaagctttt gaatttgtgt ttctattttt
    62401 tctttactta aagccacctt tatagctttt tcaactattt tgtctccttc taccaccgat
    62461 ttatttccac aaaaatcact tataaaaagc tctggctttt tacctagttt aatactcact
    62521 tttgcacgta tattagtttt tatgaactct ttatcttgct gaaatgtagc ttgtactcta
    62581 tccatcaatt cgctgtcaga agtcttatat ataagctgat ttctctttgc ttctccaaca
    62641 aaatctaatt ctatcaaatc ccctttatgt gctattgtag ttatctctcc atcctttatt
    62701 attcttccaa tagtacctcc acctaagtta attccatcac ctttcttaag cgtattttct
    62761 agcattactc taagtctttt gttctttcta ttataatcta aaacttttcc aatatatagc
    62821 ccttgattat taggtctatt agagttcatt atatccttac caacttcacc taatatatat
    62881 ccttttgtaa actttctatt aaatatggta tacaaattat ttattatttc ctcagaaata
    62941 cttatttttt tcttatctac aaattcatta atcgcttctc tatatcctga aaccacagta
    63001 gctacatact ctggcttttt cattctacct tcaattttta aagataatac acctgcttca
    63061 attattttat ccaaatcttc tatagtactt aaatctctag gactcaacaa ataatctcca
    63121 ttacttttta ctacttctcc tgtatttata tctatcaact catacttttg tctacatggc
    63181 tgtgcacacc tacctctatt tcccgaccta ttgcctatca tactactcat aaggcattga
    63241 cccgagtaac atacacataa agctccatgt acaaaaactt ctatatctac agttgtattt
    63301 tcacaaatcc attttatctc atcaacattt aattctcttg ctaaaacaac tctatcaaac
    63361 cctacactct gaaggtattt tacatcttct aaggaatgtg ctaccatttg agtgcttgca
    63421 tgtagttcaa agtcaggtaa tagttttttt ataagtcttg ccattcctat atcctgtact
    63481 attaaagcat caatatctat atcgtataaa aattttacat actctacaaa atcttctatt
    63541 tcatactgtt ttatcaatgt atttacagta acaaagactt gcactcccct tatatgagag
    63601 tatttaacag cctcaatcag ctcatttcta tcaaagttat ttgcagatgc tctagcacta
    63661 aagtctttac cacctaaata cacagcattt gctccgtttt gaactgctgc ttttaatgaa
    63721 tcaaaagagc ctactggtgc aagtaattct atttttttca tatttttctc ctctatttat
    63781 acttgttagg ttaatataat tatatctata acttaaatat ttgtattaaa tttatatatt
    63841 tcttactata ttttaaattc ttcaatcaat ttatatatta gttatttata tttggttcat
    63901 ttgagttaac atatacatta tttactatat ttagtatatt tctattaact tatatattga
    63961 ttactgtatt ttaaattctt caattaattt atatactgct tactaaattt aaaacatttt
    64021 aattaatttg tacactgttt actatacttg aaatacttct attaatctat atattgccta
    64081 ctatacttaa gacattttaa ttaatttata cactgtttac tatacttgaa atacttctat
    64141 taatctatat attgcctact atacttaaga cattttaatt aatttataca ctgcttacta
    64201 tacttaaaat acttctatta acttatacat tgcttactat attttaaatt ctttaattaa
    64261 tctatacaat atttgctata tataaagtat atcaaataac agcttcattt ttttgtaaat
    64321 ttacagaaag ttaattttca ttaaatgaat catctttatt gataaacata attccaaaga
    64381 ccactgccaa aataaaaaaa catattagta ttgatttttc cacgaaaatt tttgtaaaaa
    64441 aagttcctaa aatagctcca gatataaaga atataataat agcataatac tgtaaactct
    64501 tttttatcat aaaaatattc ttagtatgta tataatgaaa taaagtttct gtagcacttc
    64561 ttaaatttcc agtacacatt gtcgttgcaa aactattccc atttactttt ctaaaactct
    64621 ctacttgcat tgaacaaata aaagaaatag caacatttac aaacatatta aatcttcctc
    64681 taggaataaa tgaaacaata agtattgtaa tcatttcaat tataatgata acctgacgcc
    64741 aatgaatctt tgtcttatta tttgtaaaat actttcttat cttctcggct ataaatacac
    64801 ctaacataaa tgccaaaata ggaatcaaat aataaaatga ttcctttaca ttaccttctg
    64861 ctatattaag cccaaataaa actatatttc cagtttgtgc attagcaaag actttacctc
    64921 ttaccacata agtataaata tccaaaaatc ctcctgttat tgccaacaaa gaacataaaa
    64981 agaatgattc agacatctga ctcttgcttg tcatatataa acctctcgct ttctaatgat
    65041 agatacaaaa tcaaaatcat tttagattct atttttcatt gatataaaaa aattatttat
    65101 atttaaatat tgtctatatt tatacattat ttgtatttat atagcattca tatttattta
    65161 tatttaaaca ttatctatat
//
LOCUS       DAEHWM010000007        65036 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.007, whole genome shotgun sequence.
ACCESSION   DAEHWM010000007 DAEHWM010000000
VERSION     DAEHWM010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 65036)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 65036)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..65036
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.007"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            539..3181
                     /gene="adhE"
                     /locus_tag="KNP36_000502"
                     /gene_synonym="adhC"
     CDS             539..3181
                     /gene="adhE"
                     /locus_tag="KNP36_000502"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HBF0872396.1"
                     /translation="MEKKEKVVEKSNVEVCSPEIVNSVETLRMRLEEIRLAQKEFATF
                     TQEQVDKIFLAASTAANQQRIPLAKMAVEETGMGIVEDKVIKNHFASEYIYNAYKDTK
                     TCGVIEKDEAFGFTRIAEPVGVLSAVIPTTNPTSTAIFKSLIALKTRNGIIFSPHPRA
                     KNCTIEAARVVHDAAVKAGAPKGLIGWVDVPSIELTNVVMAEADLILATGGPGMVKSA
                     YSSGKPAVGVGPGNVPAIIDESADIKMAVSSILVSKSFDNGMICASEQAVIVPEKIYE
                     EVKKEFKYRGAHFLNKEETEKVGKVVIIDGSLNARIVGQPAHVIAKMADVEVPKTARI
                     IIGEVESVELNEPFAHEKLSPVLAMYKSKSFEDAVAKAEKLVADGGYGHTSSLYADSI
                     NHPERVEKFVNAMKTCRVLVNTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVSENVG
                     VKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVAAREFKDVMDKKKAFIVTDSFLY
                     NNGYTKKLTDLLDEMGIKHTTFFDVAPDPTLACAREGAKAMADFQPDLIIAVGGGSAM
                     DAGKIMWVMYEHPEVDFQDLAMRFMDIRKRVYVFPKMGEKAYFAAIPTSAGTGSEVTP
                     FAVITDQDSGVKYPLADYELMPNMAIIDADMMMEMPPRLTAASGVDALTHALEAYVSM
                     LRTEPADGLALQAGKIIFEYLPRAYKNGKNDKEAREKMAMASTMAGMSFANAFLGICH
                     SLAHKLGAFHHVQHGVANALLINEVIKFNCAEAPNKMGAFSQYRYPDCIQRYAEFASF
                     AGIKGSTDQEKVDNLIKAIDELKAKVGLPKTIKEAGVEESKFLERLDAMVEQAFDDQC
                     TGANPRYPLMSELKEIYLKVYYGK"
     gene            complement(3541..3882)
                     /locus_tag="KNP36_000503"
     CDS             complement(3541..3882)
                     /locus_tag="KNP36_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872397.1"
                     /translation="MLLILGNLNLNLDFDYRIIREENEDVDIFIDINYRSLDIDTDGS
                     NLFNSRIQFPFVRALILRLNKNNQCMTIHLLRDIDLFSAFANFEVDYTDSIINIKNQN
                     EKVILNKSIKK"
     gene            complement(3909..4580)
                     /locus_tag="KNP36_000504"
     CDS             complement(3909..4580)
                     /locus_tag="KNP36_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872398.1"
                     /translation="MPILETINLGKIYGKKETSVHALKNANLKINKGEFVAIIGPSGS
                     GKSTFLHLVGGLERPSNGTIKVDGKDICCLSDKELARYRRQKVGFVFQQYNLIPVLNV
                     KENIELPLKLDNKKIDKEYIDDLINLLGLNERKNHLPNQLSGGQQQRVAIARALSAKP
                     SIILADEPTGNLDSKTTEEVMDLLKSSIKKYNQTLIIITHNENIARKADRIISIIDGE
                     LKLTL"
     gene            complement(4592..7168)
                     /locus_tag="KNP36_000505"
     CDS             complement(4592..7168)
                     /locus_tag="KNP36_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0872399.1"
                     /translation="MKDNLKIVLRYIKSYKARSLAIVVSIILATSLVVGIGTLSRSAQ
                     QADVDRLKRELGTDHVYFKNIKKNQLKSIKSSKDIKNLGITSYYASTDVNEKLPINIL
                     YTNKNYLTSHSKLIKGRFPKASNEVVVEKWILNSMGLKPEINQNLTFKLYQKENPETF
                     KVVGILEDRFIEKKKGQCEIFSNLNESELNDFTTYIEFNEGSDINTNIDNIIKNAMLD
                     EKSIGRNSMLIESTMKNGTLDNSSKYVAIAMSLFAGIVIYSIYVISIYQRVQEYGVLR
                     AIGSTNFRIFKLMLYELFILALIAMPIGICIGMGGAQIFNRSVGNIQFEGNINVTPFV
                     IPDKIILLSIACTILIILIISFFTYLKIRRISPIDAIRKTFGADKNVTKVNYLISKLT
                     LNMSVTKSISAKNIFRNKKGFIIIVLSMSIGGIIVIKDNYKYSFLDVQNKSTQEQTYM
                     NADFILSNVYLNEIGNNTSFKDIKGFNDNQIDKIKNIDGIDKVKTASILNTRIEVNKI
                     NRLDYYEAINSTPYYKLNPLFIKNKTTGKYTLKQKLKGYNDEMIKSLEKYLVSGNINL
                     KKMKKENLAIVYVPEISKTQKYTKTFTPGEGTPAVDIKVGDTIKVKYPKGGMDTGLYE
                     SLKDNYEYLEYEFKVGAIISYPFADNGMYSGDDGVDVITSSEYLKKLTGVDKYNLVYA
                     DLNENANKKKINNLLGKIGSEVPGTTTVDMMVEKENSDKMTSRTMIYSYGIVAIMFII
                     SVLNIINNISYNLTSRTSEFGMLRAIGISERGFKNMILYEGILYGVLSSIITIVSGII
                     IQFKMYYMQGFVSYGLGFSIDYKIYILVVVANIIVGILATYIPSRKINKISIVEAINI
                     TE"
     gene            7376..8311
                     /locus_tag="KNP36_000506"
     CDS             7376..8311
                     /locus_tag="KNP36_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0872400.1"
                     /translation="MDNNFVFPIVILTLFIFSNLIMNKYKFYKELDILKRGILTFFIS
                     CFALILFMEGTKYIQLRLGYSFLLEGVLNIILFLVLIILSFYTGFKVIRLINNNNEQE
                     YKLQKLDSKINHKDNIIIKLRSQKHDYLKHLQVVYSLLNTGLDEDAKEYIMNISNSFK
                     SKNSRYGKVSYLDAIASLKYEECLEKDISFDVYIQDFMDNLEIEPNDMSSVLLNIIDN
                     AIESLSTIKKEKKYIRLHAYEDEFQYIIAIKNNGPKIHNVESIFWNGFSTKEGQDRGY
                     GLHLVKNILDKYDYSILVNSDDFLTEFVILIPKYY"
     gene            8330..9067
                     /locus_tag="KNP36_000507"
     CDS             8330..9067
                     /locus_tag="KNP36_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872401.1"
                     /translation="MIKVLICDDDKIVRDDIANIAKESGYVDYVKKVKDGIEAIEFIK
                     NEKIDLLIIDIDMPYKNGIDSAEEILSIDKDIHIVFVTGFADYSLESFKVHPIDFVVK
                     PFKKEKILDSINIAIDHINSHKIANNNFIEDTLFVYKIRKQIHMINFDDIVMFEKNSR
                     AINLHTKDEDIIKFYENFDDLKKRLPPNFFMTHRQYIVNLRFIHKVIPINKSSLEIRF
                     INFQENAILNKSLEKDFLYRFYRVKRF"
     gene            complement(9252..14309)
                     /locus_tag="KNP36_000508"
     CDS             complement(9252..14309)
                     /locus_tag="KNP36_000508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4132 domain-containing protein"
                     /protein_id="HBF0872402.1"
                     /translation="MLERTRVEKNPKIIENFKNNFTKSSSKQYYDLAKSLWDCIENSS
                     YYYREPEDKFLNMIKKYYNCHYYEIKNMDELLSGPLKNALELIFTSEQVEELCQLIKR
                     KMDYTYSGGYYRKGYRSNKLVDYFRGIIRFISNYVDLIYYDFSVIDYLTLPNKVLYYD
                     SIMSDKIALEIDKGNQKVISALEEVIFGENQTALLTRQMIIGIMKSHSDKCYEMLSKL
                     LLAAKQQEGLRQQIVESLDEGTISASIYMLKTILDNNLERFSSVIRALDTWTGLGFSD
                     QKPGIIRKCLELSYKSLTDEKFRIESINSNDNLEIYFALWATATYNIYDSYSLIENLL
                     SCQEKYKKLVALYFLSHTESTYFKHSIASKNIKGDDLEILAWVITNFYVEGSVGYYYS
                     WQNRETNFDLSNTPIDKDFDARKEQFESLKHTLEILNSKTKSFSGSVFPWTWIEISSH
                     EILKCMMTLTAYDMNAQFIDVLMENCHLMSSDLRASLIVNFVNEPKTDRQREFLLECL
                     SDKSVSNRETVLSLLRKLELTDVELDKITNLLSLKTSSIRQTVIKILLEQDDSNLENI
                     ASSLIKSSNSQKCLGGLEIVNLLKDNTARQELYNKLILLIEDIDKSKKNTSQVQILID
                     NLLGKAKNDYCKENGFGIYNPENKVQIPEQFDFKDDSNSSSKLNKIISNISLSTREDS
                     VSVATKKEAKKILDTDINKIIKVYEKFDELITENADYEYEVERWSGNVDKVLLGYSTY
                     NLTPIKYKVSNDTLDNYPLAELWRETSKKLDLDYKLILDILFYSISTCGYNETEKSWF
                     SSIYSNVLDSKKQNKIYTKLEKLKFNGLTRKLLRVLLNEFDHKEIFNYCLEIYYKLRN
                     LLTIEQCKKQRVEFTKNYYRQNEYCPALNAPILNYWLDKAHSFIYDDISFTKFFYTTF
                     SNYQLLEYKFPFYTSINVFARAHELGLMTEEQVNREMISGYNASNIIRTLTNPRWAGD
                     TLEKYPWLKDNLKTVTNRIIEIESRRGDMPTEVSNLANNIQYFEGINYFVNILVALGK
                     ETFQRGYSYGSNYSKKDVLSSLLKNCYPTKEDDSKKLKSLLKNTDITELRLIESAMYA
                     PQWVNIIEKYLNWKGLKSTIWYFHAHINEGFSAQKESEVALFSPISPRSFIDGAFDVD
                     WFLDSYKTIGEERFNILYKSAKYITSGGNSHRRAQLYADATLGKLDKDMLMKEIETNR
                     NQDKLRSFSLLPMKKGDLKEATFRYEFIQKFAKESKQFGAQRRESESKACTIALENLA
                     RSAGFGDVNRMMWALETEKLNEVAHLFKPKDIDGTSIWIDVDENGKASTKVQKGNKSL
                     KSIPKAIAKHPYVLELKSVQKDLKSQYSRAKQSLEQAMKNEIVFTVKEIANIYKNPVI
                     CPLIKNLVWVCDDNIGYVYNDKSKFFICNIEGETYKLTAKNKLKLAHPVHLFESGKWS
                     EFQHDLFSKQIVQPFKQVFREYYRINSDELSEKTISRRYAGHQIQPKKTVALLRNQLW
                     TVDYEEGLQKVFYKENIVAKMFALADWFSPADIEPPTIETVEFFDRKTYKSLELASIP
                     PILFSEVMRDIDLVVSVAHAGGVDPETSHSTVEMRIAIAKELLLLLKINNVNFEGSHA
                     LIAGNLGEYSVHMGSGIVHKKGMGALNILPIHSQSRGKIFLPFADEDPKTAEIMSKIL
                     LLAEDSKIKDPSILSNL"
     gene            complement(14334..14753)
                     /locus_tag="KNP36_000509"
     CDS             complement(14334..14753)
                     /locus_tag="KNP36_000509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872403.1"
                     /translation="MQIYFRVKAVGKRKPMLELTPFDVSDNINCLKEAISEIVSKNVL
                     EYNEKIPEKSIINFLTNEEIESQADIGKVGFGSIYNENKQSVEKAIEVALQAFEDGIY
                     KVLINEDVIEKLDSSINLKSGDIFTFIRLTLLAGRMF"
     gene            complement(14987..15238)
                     /locus_tag="KNP36_000510"
     CDS             complement(14987..15238)
                     /locus_tag="KNP36_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872404.1"
                     /translation="MNRYTKIINMMGSYYTKDFEKEKKNVIKVREVKEDTVRKFFLQG
                     DCEVLVVFEDTGKEILIDDFSPEEDIKKYLGAKFINKKR"
     gene            15327..16058
                     /locus_tag="KNP36_000511"
     CDS             15327..16058
                     /locus_tag="KNP36_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkgJ family cysteine cluster protein"
                     /protein_id="HBF0872405.1"
                     /translation="MTSIKNKDILNCIDYSIKNKLFDKLNDVYKSLPVGNCSGCGNCC
                     MESVGINLIEFLNIFCYLEDRVDLKKSCISKILDYYFEEYTRKNPCPFKDTNNRCLIY
                     EVRPLNCRMFGHWKKEDYNKNLDNVIEKNNNYRELMKKQYGFEINDEVVNYRIDYCDR
                     FIPNKDYLSKSKRLSFFDELMILDSNIYSSGNIDIDFRDRGIVEYFIESLLYRNLAYN
                     VKIRISKEYKIRKRTIDRIKRIVLV"
     gene            16117..17028
                     /locus_tag="KNP36_000512"
     CDS             16117..17028
                     /locus_tag="KNP36_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0872406.1"
                     /translation="MNLTKVKGNTFFIKGGTNTGIYVFEDNTALMIDPGLCGSRPRRV
                     NKVLDENNIQVRYIINTHGHDDHYGACNQFKEYYKDVCIMSSEYDKLYIENPELFSKY
                     IVGGKSNVFMDNILKNKMLDDIKIDKSIEAGKIELNNEMFDIIEFQGHTPGSIAVLTK
                     DNVIFVGDLLIGDEILSKYDFLFLYDIQEQINSLEKLKNIDFEYLVLGHGKQVISKED
                     SYKLIEKHLNALKKYLYQIRELLVEPKSLEILLKNIINNNNLSNNYKEYHFFKSSLVS
                     VISYLVDLEEIGYILENGELLYYTKTK"
     gene            17079..17891
                     /locus_tag="KNP36_000513"
     CDS             17079..17891
                     /locus_tag="KNP36_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HBF0872407.1"
                     /translation="MEYEKWNEILAPYEHAVEELKIKFKNIRKEYLAKGEYSPIEFVT
                     GRTKKISSIISKLKRINAKDIETEIDDIAGIRIMCQFVEDIYAIVDLIKVRNDMTIIG
                     EKDYITNYKDSGYRSYHVIIKYPINSIAGSKEIICEIQIRTLAMNFWATIEHSLKYKY
                     DHYIPETLAERLRRASDAAFLLDQEMSEIREDIMKAQAMYQMKSIAIRDTLNRIQELY
                     DLGDTHKAMQYQRKLDRTETDKNITEILELKQEIDILLEQYKDTKVDDKVVQ"
     gene            18000..18692
                     /locus_tag="KNP36_000514"
     CDS             18000..18692
                     /locus_tag="KNP36_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0872408.1"
                     /translation="MSLYAIGDLHFSTSVNKPMNIFGSNWDGHEKKIIDNWKEVVKEE
                     DMVLVLGDTSWGINLSEAKKDLDIISKLPGQKILIKGNHDYWWTTVTSLNKLYEDMRF
                     IQTNFYEYKDYAICGGRGWICPNDVKFDETDEKVYKREEHRLRLSLESARKSGHSKII
                     VITHYPPTNDKLEESLFTKLFEEYNVEKVIYGHLHGKESFKMGLKGIRNGVEYTLASC
                     DYTEFNLIKVHD"
     gene            18779..19720
                     /locus_tag="KNP36_000515"
     CDS             18779..19720
                     /locus_tag="KNP36_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872409.1"
                     /translation="MRWILVFIFLYLIPLVVIFRNYKNFKRSCIYSSIYVVLATTIMI
                     SNIYMSGLNKIKESMYYHNYISDETYDEKYVSNFKEKESTDLKQDNKKNEEISNNKNL
                     NNKQDRNIQNKESNEEGSNDIKEKNNSDSNVSVNNKSEKQEDNTKENNKYTSKEKNSE
                     DIKKIDMESIGIFKKEIYNIERAALVPMRECIPYTKDIAKNITKLSSIKKDVTNARNK
                     CKEVVKEYENMQIPELSKEKYTETLSNARDDVKKAYELREKSMESALKLINTKSPKYI
                     GKITEYLDLSDKQIESFKNRLNDLKEEINNSETNNIN"
     gene            19757..20914
                     /locus_tag="KNP36_000516"
     CDS             19757..20914
                     /locus_tag="KNP36_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBF0872410.1"
                     /translation="MNKQSIGKLNMFFMGITQRNLDNRDFFIELEVIFKSGRKEFKGI
                     AIEEDNKYKFNFKGKSDLYTFNELLKNISKEAENYDGLVFKYVERGTIVVIEGDNKKV
                     NVKYLDNKEEVPKIDEFTASQIKNRDYYVKVGQANALLKEIGVLTKDGKIKNDKIRKY
                     NQIDHFVELIDSILKEIKDKDCITILDCACGKSYLSFVLNFYIKEVLKKNCYFIGIDY
                     SDVVIEASKNMAKNLGYKNMSFIKEDLTNYTPNRDVDLVISLHACDTATDMAIGLGIR
                     AKSEAIVVVPCCHKELLGQYRYEAMEPILKHGVFKARFADLITDGLRTLLLEGNGYDT
                     SVVEYISPLDTPKNLMIRAIKTKTNNDKALKEYKELKSQFGVEPTLEKLIY"
     gene            21066..21626
                     /locus_tag="KNP36_000517"
     CDS             21066..21626
                     /locus_tag="KNP36_000517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBF0872411.1"
                     /translation="MNKLNICIDIDGTITSPYHFLPYLNDIFNKNITEAECITHNWEE
                     LYGSGIRDVYAEFNNKYIHSYDEAKIVEGATEVISTLSKGHNLSFVTARHECLTDVTK
                     NWLSRQGFSDIDVYLLGSDYKVEKARELSCDIFIEDNPLNSVQLADDGVKVILLDTNY
                     NKDVKHQNIVRVSNWIDIEKIIKQGI"
     gene            21654..22145
                     /locus_tag="KNP36_000518"
     CDS             21654..22145
                     /locus_tag="KNP36_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872412.1"
                     /translation="MIDLKIENRKGKIHVKSSEIKDILELRPDFEYVQDISNTINQEN
                     ILVFDCQLTGNSFDMDDLDIEEILEELGEEIDESYFSVLFEDVRAYLKDATDEIEADL
                     QDNYLFDNLRCYFDIYNINQEFTDFKFVFLVSFKDIKISSLANLAKIVSKRQLIGASK
                     FYS"
     gene            22374..22925
                     /locus_tag="KNP36_000519"
     CDS             22374..22925
                     /locus_tag="KNP36_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872413.1"
                     /translation="MQSLNEIIAENLKKIRKEKHLSLDKIAQLSGVSKSMLSQIEKCE
                     VNPTISTLKKITNGLKISFTSLMERQESDIELIQKSDIDHFIEDNGKYISYPIFPFDS
                     KRRFEIFMIEIEEGGNLDSNAELPGTQEFITVFSGEVTIKINGEDYIVSSGNSIRFKA
                     DVSHIYRNSGKGIAKMSMVVYYI"
     gene            23011..23943
                     /locus_tag="KNP36_000520"
     CDS             23011..23943
                     /locus_tag="KNP36_000520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="HBF0872414.1"
                     /translation="MNNKKAVFFFCSDLKKDPVASNVIKCCEEIMDLNQTDIVIDDNF
                     VLEFKDKNNNLFHFVKTKDVISHNYKYYLPILNRHFRDYDFAGVVNWHEGENAPEHIL
                     TAHTIGDVPTGEFGNSNPRYFKNLINAIEDIKNENLLDEFTTLTEATHWSGTTYGEES
                     KLITEYSVPMLDIEIGSSSDSFNNSIAIQVLAKSLIRVFDCDEPLKTLLCVGGVHFEK
                     SFSDIIKNKEYNISIGHVLPNQWIVSGMYDDESGFEKLEKCINSIEGGIDCIVFHDKL
                     KGTYKEQCRKLGEKLNVPVFKHKILKNPKDLPIW"
     gene            23998..24861
                     /locus_tag="KNP36_000521"
     CDS             23998..24861
                     /locus_tag="KNP36_000521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBF0872415.1"
                     /translation="MILSYFALLIRVVLLAFERVVVRLLGDEEGDIYKNIASSFLFFF
                     IGGVCLLPFSIMDRVSDWSFLIPCYISSLVYSIGSVAYVTSLATGEVSLVTPINSLNS
                     LFLLLLSVIFLGEGLSLAKVAGIIIMIGGVFILKKVSSFLKNVSVIFNNLPCRLMFLY
                     IFLQSVGRVLDKAFFVQVSPILYSTILYFFVGLNLFIFLAFKKKQKIICEIFTNKKGL
                     SILSGAINGYSYLALLIALNNLELSIAEPFSQVSMIITLILAHFIFKENIKEKIPGSI
                     LILIGGWLLLL"
     gene            25108..26970
                     /locus_tag="KNP36_000522"
     CDS             25108..26970
                     /locus_tag="KNP36_000522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0872416.1"
                     /translation="MNYKKTAIDIIEQVGGSKNILALEHCSTRLRFKLIDRSKVNQDA
                     LKKVQGVMSIVNGAQFQVVIGNSVVDVYDEILKVCPLDTNDSTVKTEEKINLGTRFIE
                     FIINIFQPLIFAIAGAGILKSLLMLLAMFNILKSDSTIYTLLVAISDATFYFLPLMVA
                     VTTANVLKCNRLVAIAAVGYLLLPATTTALSEGVELFGFTIPNIAYNAQVFPAILCVS
                     FLATMEKIFNKYSPKPIRTFFVPMMSLAITVPITLTILGPLGYNVGTIFTTIILFLYN
                     KMGFLVVGLLAAFLPFMVATGMHKALIPYSINTIGKLGYEALYMTSSLAHNISESGAC
                     FAVALRTKDETLKQTALSAGISALMGITEPALYGITLQHKRAMLGVVFSSAISGTFLG
                     LFAVKGFVIVGSGLASMSMFIDPNNGNNLIFASIGFVIAILGSFIITLIIWKEDTNTV
                     ESSIGDVVEEELEEEKEVNILVTPVEGKVIDLSKVNDELFASKTLGDGVAIIPTNGNL
                     YAPCDSEVVMLFETKHAIGLRTKNGAEILIHIGINTVSMNGDGFKTFVKTGDNVKEGD
                     LLIQFDLDKISHANLDSTVMIVNNNGADYAYKVLNQSYGNVKKGSILFDVKGGI"
     gene            26973..28439
                     /locus_tag="KNP36_000523"
     CDS             26973..28439
                     /locus_tag="KNP36_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000110363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBF0872417.1"
                     /translation="MRKFPEGFLWGGATAANQFEGGWNLGGKGWSVSDVAKAHFDADV
                     KDYKSNNEITTKDIEEGLAHPEDEVNYPKRHGSDFYHHYKEDIALMAEMGFKTYRMSI
                     AWSRIFPNGDDKEPNEEGLQFYDDVFDELISYGIEPLVTMSHYEPPLNIVLNYDGWYS
                     RQVINMFVRYVETICERYKNKVKYWLTFNEVDSMIRHPYTTGGLVRDRFKDKNFEEVI
                     FQAMHHQFVASAIATKICHEIIPNSKVGCMLTKLTYYPYTCRPEDVLATQQKMRSIYA
                     YSDTQVFGEYPVYLLSYFKNNNIQIVKEEHDDEIMKKYPVDFISFSYYMSSCEAADTT
                     GLDITPGNTLLAVKNPYLEMSEWGWQIDSIGLRISLIELYDRYRKPLFIVENGLGAKD
                     ILTEDKKVHDQYRINYLKEHFKCMLDAIIEDGVELWGYTSWGCIDLVSESTKQMSKRY
                     GYIYVDADDYGKGTYNRYKKDSFYWYKKVIENNSIDFK"
     gene            28463..29299
                     /locus_tag="KNP36_000524"
     CDS             28463..29299
                     /locus_tag="KNP36_000524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0872418.1"
                     /translation="MNYIIKKVLNSSVVLVHDAKYNEFILLGKGIGYGKKTGEYICGS
                     NDNQMFVPVENTKSKQFLELMDDIPVDILKITQEIIVEAEKLLNSSFNKNLYLILADH
                     FNFAIERMRKGIKITNRVFWEIKNYYPNEFKVGMVAIYMVEERLGIQLPEEEAANIAF
                     HFANAMASDGNSYDTIKYAKVIGEIINIFVFSLNRTLDKKSMHYMRFITHIKFFVERF
                     FSDSMLSSGDDLLFNQMKRSNPKEMLIALKVRDFLEKKYGKKLTNEEIAFLVVHIARV
                     KQ"
     gene            29865..31448
                     /gene="asnB"
                     /locus_tag="KNP36_000525"
     CDS             29865..31448
                     /gene="asnB"
                     /locus_tag="KNP36_000525"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBF0872419.1"
                     /translation="MINLEEKYLTRKDTYMIKILEYNGHIRNWKVLCEELGIDSSLCR
                     DERERAILVEAYKTWGYDMANHMHGMFAFALWDTVEKKLFCLRDQFGVKPFYYYETEN
                     GKLLYGSSIRKIMEQPGFVKELNEDMLQIYMSFTYVAGENTFFRGVKKLMPGHYLVYQ
                     NKTVCIGRYWKPEFHPDHSKSIEEWTDEIHTTLQKIMPEVKSENETAELFLSGGVDSS
                     YILAMSDIEKTGSCGYEEERFDESKLAQQTANILGCKNSRYIITPEEYFASVPYVMYH
                     MEQPTGDASAIVFAIGCKAAAENTNICYSGEGADEFFGGYNIYHKAECYGENLKTFYI
                     GNTNIMNEGEKRKILKKYNPDVLPIEVVKGIYEETEELDTLTNMSNVDIQIWLEGDIY
                     FNIDKMSTAVGLEVRMPLTDTRIFDIASRIPSEYKVKGKENKIAFRTAASKTLPEEIA
                     FRNKLGFIVPIRIWMADDRYNKDIRDKFNSEIADKFFNIDEINEIFNDYISGNSDNWR
                     KIWMIYTFLVWYEIYFVKC"
     gene            complement(31513..32109)
                     /locus_tag="KNP36_000526"
     CDS             complement(31513..32109)
                     /locus_tag="KNP36_000526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04100 family radical SAM protein"
                     /protein_id="HBF0872420.1"
                     /translation="MNILYTIENSIYVNITNTCPCSCVFCIRNEKDEVANSGSLWLEH
                     EPSVDEVKEAFNKYNLDDYDEIVFCGYGEPLMRINELIEIAKFIKEKSSIKIRINTNG
                     LSDLIHNKKTAILLKNVIDAVSISLNAPNKEAYNRVTQPKFGEKSFDYMLDFARDCKK
                     YIKEVAFSVVDEISPEEIEESKQLAKKLDIPLRVRHKN"
     gene            complement(32136..32663)
                     /locus_tag="KNP36_000527"
     CDS             complement(32136..32663)
                     /locus_tag="KNP36_000527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04002 family protein"
                     /protein_id="HBF0872421.1"
                     /translation="MEKMNKVTSKKTTYIVTSALFASIICLTIAYILHIPVGGNNGYV
                     HIGDAFIYLAATILPTNYAIAASAIGAGLADLSTGAAIWVIPTIIIKPILVLFFTSKS
                     DKIINKRNIVASVVAGIVGLVLYMFAEGIIIGSFTSAFVMSLLGLLQPIGSFIVFIIL
                     GMALDKLDFKKRYFN"
     gene            complement(33025..34023)
                     /locus_tag="KNP36_000528"
     CDS             complement(33025..34023)
                     /locus_tag="KNP36_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="HBF0872422.1"
                     /translation="MKILVFGARDYEEPVIKKWSEEHKDVQVDIYPENMTEENVVKAK
                     GYDGISIQQTNYIDNPYIYETLKDAGVKVIASRTAGVDMIHFDLVNENGLIVTNVPSY
                     SPNAIAELAVTQAMNLLRKTPLVKKKVCEGDYRWIAELLGTEVRSITVGVIGTGKIGA
                     TSAKLFKGLGANVIAFDQYPNSDLNDILTYKDSLEDLLKEADLITLHTPLLEGTKHMI
                     NKDTLAIMKDGAYIVNTGRGGLINTGDLIEALESGKIRAAALDTFETEGLFLNKKMNP
                     GELTDPEINKLLSMEQVIFTHHLGFFTSTAIENIVYSSLSSAVEVIKTGTATNRVN"
     gene            34700..35899
                     /gene="hadA"
                     /locus_tag="KNP36_000529"
     CDS             34700..35899
                     /gene="hadA"
                     /locus_tag="KNP36_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isocaprenoyl-CoA:2-hydroxyisocaproate
                     CoA-transferase HadA"
                     /protein_id="HBF0872423.1"
                     /translation="MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRV
                     MGGTFKSPASDDENPMFELENGNKKGVSINVKSKEGVEILHKLLSEADIFVTNVRVQA
                     LEKMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGT
                     SPANTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQ
                     YGNEMPLSRENPNSPLMTTYKCKDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYN
                     NIDSMVNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQSCEDLLDDEQAWAND
                     FLFKKTYDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFK
                     DSKVVRY"
     gene            35938..36738
                     /gene="hadI"
                     /locus_tag="KNP36_000530"
     CDS             35938..36738
                     /gene="hadI"
                     /locus_tag="KNP36_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyisocaproyl-CoA dehydratase activator
                     HadI"
                     /protein_id="HBF0872424.1"
                     /translation="MYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRVLE
                     KLYGKTGLAREDIKKVVVTGYGRMNYSDADKQISELSCHARGVNFIIPETRTIIDIGG
                     QDAKVLKLDNNGRLLNFLMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSI
                     SSTCTVFAESEVISHLSENAKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVAR
                     NSGIVRAMAREINTEIIVPDIPQLTGALGAALYAFDEAKESQKEVKNI"
     gene            36753..37979
                     /gene="hadB"
                     /locus_tag="KNP36_000531"
     CDS             36753..37979
                     /gene="hadB"
                     /locus_tag="KNP36_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(R)-2-hydroxyisocaproyl-CoA dehydratase subunit
                     HadB"
                     /protein_id="HBF0872425.1"
                     /translation="MSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQELA
                     EVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEAL
                     DMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQF
                     EEAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYM
                     AVIVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMK
                     TLAKFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGK
                     CDGAFYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQG
                     LVEVMEERKKLNRGEI"
     gene            37979..39106
                     /gene="hadC"
                     /locus_tag="KNP36_000532"
     CDS             37979..39106
                     /gene="hadC"
                     /locus_tag="KNP36_000532"
                     /EC_number="4.2.1.157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(R)-2-hydroxyisocaproyl-CoA dehydratase subunit
                     beta"
                     /protein_id="HBF0872426.1"
                     /translation="MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIH
                     AAGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLEYGLKGAYDELSGVIIPGMCDTL
                     ICLGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKI
                     HESIEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAK
                     LNAMPEEVCSGKKVLLTGILADSKDILDILEDNNISVVADDLAQETRQFRTDVPAGDD
                     ALERLARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFCMMKFCDPEEYDYPL
                     VRKDIEDSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA"
     gene            39154..40287
                     /locus_tag="KNP36_000533"
     CDS             39154..40287
                     /locus_tag="KNP36_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003483287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="HBF0872427.1"
                     /translation="MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLA
                     DAKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCASTATFVTAGSSLASLPILYNGTE
                     EQKQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPF
                     CDVAIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVP
                     KENLLGKEGQGFKIAMGTLEVGRIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKF
                     QNTQFTIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYYASEIANEVAYKALQ
                     LHGGYGFIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK"
     gene            40320..41105
                     /locus_tag="KNP36_000534"
     CDS             40320..41105
                     /locus_tag="KNP36_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012703997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBF0872428.1"
                     /translation="MKILVCVKQVPDTNEVRINKETGTLIRDGVPSILNPDDANALEE
                     ALKIKDEHDDVTITVITMGPPQADFMLRECLAMGADDAILLSDRAFGGADTWATSNTI
                     AAGISKVGDYDIIFAGRQAIDGDTAQVGPQIAEKLDIPQVTYVQDFKIEGKDIIVQRQ
                     LEDGYELIKVSTPVLLTAVKELNTPRYMSVDKIVKAYKHDVKVWTIDDLDVNKEEVGL
                     KASPTKVFRSFTPEPRGKGEILEGKADEIASKIIIGLKQKHII"
     gene            41124..42161
                     /locus_tag="KNP36_000535"
     CDS             41124..42161
                     /locus_tag="KNP36_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBF0872429.1"
                     /translation="MNDIKDLSSYKNVWIFAEQREGKIAPVVIELLGEGRKLAKEVDA
                     ELCAILLGKDVDGLAKELITFGADKVYVADDALLEKYTTDAYTKVIKDAIDEIKPEIM
                     LFGATHIGRDLAPRIASRVGTGLTADCTKLEIDPEDKKIKQTRPAFGGNIMATIICPN
                     HRPQMSTVRPGVMDKAEKDETRTGEVIALDYKITQDDIRTTVLETVKTKKDLVSLTDA
                     NVIVSGGLGLGGPEGFEMLKKLADKLGGVVGSSRAAVDAGWIDHSHQVGQTGTTVKPN
                     LYIACGISGAIQHLAGMQSSDFIIAINKNPAAPILEIADYGVVGDLHEIVPMLIEKLD
                     SVDDLLEAIKA"
     gene            42644..44275
                     /locus_tag="KNP36_000536"
     CDS             42644..44275
                     /locus_tag="KNP36_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872430.1"
                     /translation="MDNNLIGLIEHVENPAILCKESGEIIYCNHLIDSIFSFLDIKKP
                     RNINELDSNFDKTEILTDSKKKIAFRELRMTAHIYNMKDNNNENNIVYLFEKSLISDK
                     VIEDIIEHIDEVVVVFNKDGVIEKMNTVSDEILPFKRTEVLGRNITDLVRQGLVEEPI
                     ILNMLKVKKKIYRNIVYPDGKLIAYTAVPRWDSKGKLTGGVLTGRDISRVIKLESQIK
                     YSDISEDTEYISQSKIMDNIKKVVKRAAASDSSIFINGESGVGKEIIARTIYKYSSRR
                     DKPFIAINCGAIPNELLESEFFGYEEGSFTGAKKKGKKGLFEEANGGTIFLDEIGELP
                     MQMQKKLLRVIQENTITRIGGSKPIKIDVRYISATNISHEDLRNNLKFRQDLYYRLSV
                     IPVKIPPLRERKEDIVPLVNYFLKLYNEKYNREVEVSPKVIELLEEYSWPGNIRELKN
                     IIERFVVLSAKNVIGEDEFNMLINLDMIDNETDDLSPIVVNGIMNLNDAYKIVDQIMI
                     SKAINKYGSITKAAEVIGIYPSTIHRKIKSGHIHV"
     gene            complement(44410..45336)
                     /gene="fba"
                     /locus_tag="KNP36_000537"
     CDS             complement(44410..45336)
                     /gene="fba"
                     /locus_tag="KNP36_000537"
                     /EC_number="4.1.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II fructose-1,6-bisphosphate aldolase"
                     /protein_id="HBF0872431.1"
                     /translation="MALITTKEMFKKAYEGGFAIGAFNISDLEQLQGVLKAAKAKNSY
                     VMIQASMSAVKYAGPHTLVEMVKAASDEIGVDVALHLDHGPNMDAIKTCIDAGFSSVM
                     IDGSHFDFEENVRITKEAVEYAHSKGVVVEAELGVLAGTEDDVTSDVHKYTQPAEAVE
                     FVERTGVDSLAIAIGTSHGAFKFKGEAKLRFDILEEIQSKLPGFPIVLHGASAVDQNA
                     VATCNEFGGNIAGAKGVPVDMLRKASSMAVCKINMDTDLRLAMTAAIRKFLAENPKEF
                     DPRKYIGAGRDAIQAVVESKIDDVLGSANSIN"
     gene            45666..45995
                     /locus_tag="KNP36_000538"
     CDS             45666..45995
                     /locus_tag="KNP36_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1904 domain-containing protein"
                     /protein_id="HBF0872432.1"
                     /translation="MPQIKIRGINENDICKISEKMINDLVEAVKCPRDYFEIECIKSV
                     AIRDGKIADVYPFVEVAWFDRGQEVQDIVARIITDSIRNNLDVESIDLAFTVFEKEKY
                     YENGEHF"
     gene            45995..46717
                     /locus_tag="KNP36_000539"
     CDS             45995..46717
                     /locus_tag="KNP36_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HBF0872433.1"
                     /translation="MAKKQRIDKILSNLGYGSRSEIKKYCKQGSVVVNGSEVSNPGTQ
                     VDTENDEILFNGEEVIYREYIYLMMNKPDGYISATTDKYDPTVLDLIDLSYLAFEPFP
                     VGRLDKDTEGLLVLTNDGKLSHRVLSPKKHVPKTYYAKIDGVVTEEDVEAFLEGVVLD
                     DGYKTMPSQLNILKSDDESEIELTIHEGKFHQVKRMFESVGKKVVYLKRLSMGNLKLD
                     ESLELGEYRELTDEEVKLIEER"
     gene            46744..48105
                     /gene="rlmD"
                     /locus_tag="KNP36_000540"
     CDS             46744..48105
                     /gene="rlmD"
                     /locus_tag="KNP36_000540"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HBF0872434.1"
                     /translation="MSVKKKDVIEFEVDKMEFGGTSLSQVGDRVIHMKGGISGQKVRA
                     GVKKVRSKKAEVKMIELLENSPLETEETCKHFRECGGCTLLSVPYEKQLEIKEKQVMD
                     LFLKQDLFGFQFLGIEGSPENKYYRNKMEYTFGDEVKNGPLTLGLHKKGKHIDIQTVE
                     ECMLVDEDFSKILVSSVEFFNEKKLPYYRTMNHKGYLRHLVVRKGIHTNEIMVNIVTS
                     SQEDFDMYEFKDMLLGIDLKAELVGVLHTINDGLADAVQCDELRVLYGRDYIQEEILG
                     LKFKISPFSFFQTNTKGAEVLYSIARDFIGDYNDKVVFDLYSGTGSIGQVMAGAAKKV
                     YGIEIVEEAVVAANENAKLNGLTNCEFIAGDVAKVVKDLKDKPDLIIVDPPRPGIHKD
                     AIRDICGFGAKEIVYISCNPKSLVVDLVDFKGYGYEIKMVKCMDMFPNTPHCETVVLL
                     RRK"
     gene            48503..50566
                     /locus_tag="KNP36_000541"
     CDS             48503..50566
                     /locus_tag="KNP36_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0872435.1"
                     /translation="MTKIILSNYRCFGEEPTTIEINNLTGFIGHNSSGKTALLSALMK
                     LFGEKSSDRIIERSDFHIPESIDPDSISKNELYIEAQFEFPELERGKDSISIPVFFKN
                     MVVSEPGGKPYLRIRLEANWEKSSNPEGSIDSNVYYITSTTEEINPEDKRNIKRYELD
                     QIKMIYVPAIRRPDEQLKNVSGTIISRLLNGISWSEQTKARIKTKASETEEIFFEEKG
                     VESLKKSLETQWNSYHKDIRYSNPKINFNSTDLETILKKVEVTFSPTGTHRDYRVEEL
                     GDGLRSLFYLSLVNTFLEIEEEILKSINDGKEEDIFTLIPPVLTIVAVEEPENHISPH
                     LLGRVVEKLNFISTKENSQTILTSHSPAIVKRIEPTDIRYFRICKEYECTKVKSIILP
                     NEEKEAEQFKFVKESVLAYPELYFAKLVVLGEGDSEEIIIKQMIELKAESVDSSEISI
                     VPLGGRHVNHFWRLLNDLEIPFITLLDLDRERDGGGWGRIKYAIQQLINIGHDKNVLL
                     YTCEGISQDNEFKEMHTWDVTDTENMAKWIEMLKGYDVYFSAPLDIDFAMLQSFKDKY
                     ISALTSAEGPRIKDHGKIQDIVINEDAEDESLKAAYKDRIDSDIKSTLKQEGGDGSTY
                     TEGEKELMIWYSYFFLGRGKPTTHLSLFSNNTDIDFESFPYCLKEFVNSIIEKMIDDS
                     GGGRK"
     gene            50563..52428
                     /locus_tag="KNP36_000542"
     CDS             50563..52428
                     /locus_tag="KNP36_000542"
                     /inference="COORDINATES: protein
                     motif:HMM:NF024642.1,HMM:NF024754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBF0872436.1"
                     /translation="MKRNWVSKEDWSPAAGFRLEVEAMNTVINDKNTLVVAGPGAGKT
                     ELLAQRACFLLETNTCRYPKKILAISFKKDAAENLKERLELRCGKELASRFESKTYDA
                     FAKEIVDRFRNSLDEAYRPLNNYNIAENRDVRRAFEIAGLNFRGNQTEFNKVYGNKLS
                     INKLPLHTDFVDKIFIDAWNVLLKGNKDTNFVSSLTFGMISRLAEYLIRTNRYIKKAI
                     EMTYSHVFLDEFQDTKSIQYDLVKACFFKTETIITAVGDGKQRIMLWAGARKSIFEDF
                     QNDFLSQKRTLIMNHRSAPRLVEIQKAMYNSLNEEAIDLKTNEKWNYEDGEVYLRLFE
                     DYIKEADILSEEIVELVETGIEINEICILVKQSVDIYSKEIINKLSERNIKARNEAMY
                     QEILKEDIIKTLVSLFRLSLSDRNPDDWDYIYDILGELYGIDEGYNPKILNDFITKVE
                     LMINDLKVNLNITDEKQFSDLVDSKVEYISYEKFASKFQKYKSKDYFDDLVDKFKKLV
                     WIEYNETKDWIKAIDNFEGKNSIPIMTIHKSKGLEYDTIFFVGLEDSAFWNFKNQPDE
                     DRCAFFVALSRAKRRIDFTFSLDRPAGFSNSQKHYCINEFYELFDNTEIVKKIEY"
     gene            52552..53366
                     /locus_tag="KNP36_000543"
                     /pseudo
     CDS             52552..53366
                     /locus_tag="KNP36_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728762.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            53391..53879
                     /locus_tag="KNP36_000544"
     CDS             53391..53879
                     /locus_tag="KNP36_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HBF0872437.1"
                     /translation="MYEKDYKQYIKLDIPIDEAKIKNRFEIRLKNERAYHAAVDLLAN
                     RDEEKTAFSIINRYIRFVDKDDEKIRSEWKTNDQWSYFIGEGRAKLKLTTNPEPYNIQ
                     KTLNWLSRQVAPTLKTIKRLDSLNNSTLIEGLIRYARLTDKHKKIIEQNSVNVEDIIY
                     DE"
     gene            54393..54620
                     /locus_tag="KNP36_000545"
     CDS             54393..54620
                     /locus_tag="KNP36_000545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872438.1"
                     /translation="MDIVKVFANNVRKYRNKKGLSQEAFAEKAGLHRTYICAIERKKR
                     SIALDNVQKIADALEIETYLLFIEGEEKECL"
     gene            54617..57556
                     /locus_tag="KNP36_000546"
     CDS             54617..57556
                     /locus_tag="KNP36_000546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HBF0872439.1"
                     /translation="MKKLPIEKLIENLGFSGSKNLVNIDMLTKLDISKHDVKTLKVIN
                     PYAIYLVNSKPFILFIESSFEEKKLQQISKLIWNAQIPIAFICDSNSVKIFNGKALDL
                     KSYLIEEIYNQSIEDFSEESEFSYLKISDPLFWDQYTKQYTKTHLNDYLLDNITSLTN
                     KLKKKYKVKFATKLVLRLIFIRYLIDRGVDIAYKNFNHDIKASQKELLKITKNKVELY
                     ELFKYLKEKFNGNLFELNDEINNTCLTDEVFILLSDFLSGKISIDNGQMSLFSMYDFN
                     IIPVELISNIYEILLGKEIRNKDNAFYTPNYLAEYILDKTTLEFLKNNRQYKILDPSC
                     GSGVFLVNSFRRIIDMNLGDKLFCEDDKLLKELLLSNIYGIDINEDAIDVTIFSLYLT
                     ILDYKDPKILSEFKLPNLKGCNLIASDFFDDNKLESLKKINFDFIIGNPPWGSVSDGL
                     HLDYCNKNGYNDMQQNKEISRSFIFRAKDFSSRNTVCSFVVHSKILYTQKKPSKKFRE
                     FLLKKSQIFSVVEMSSVRKLVFKNADAPAAVISFKYNESEENLNNRIIYTSLKPNVFF
                     KLFNIIVIEKYDVKYISQKLLLENDWAWKTIVYGFSKDIDIIMNIKKKYQTVNEIILK
                     NSFVHGTGIQINGNESHDATHLKGKWYVDSKKGIDSFYVDINKGKELTQDKMRRPKAN
                     QQEIFIPPYVLLKKGVDTKTYRYRAAFSNDAFVYSDAVTGICGKKDNLTTLYCLTGML
                     NSSFYSYLNIMLGTSIGIEREQGFSTEIFTYPAIESDEIANLVVKIQEATKLEKTTMF
                     LNEKNSCKYIKQLDKLILKSFNLNDDKFIDYAINIQIPELTNSKSTNIYRKITKEDLI
                     NYSECFKEQFSSIYRRVGKSISISVYPKILNRFTVFELEVTDEKTDREIMVKAEADNN
                     MELFTKIIRYDYNDVFHQIRDIIHFGENSFYIIKPNCYKYWHPAIAEMDLADVLDQIL
                     SDTGGEE"
     gene            57556..58230
                     /locus_tag="KNP36_000547"
     CDS             57556..58230
                     /locus_tag="KNP36_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872440.1"
                     /translation="MGGFKNSSLNFYLKQGLYEIIIDGLIDCCLLMSKSCIEQSRKIL
                     NHEEKIRTHLVENYLENDIERRKTSLSKQHLRFEVEAQENYDNKNESYEGRVDIKVIS
                     KDTLADRRAYYIIECKRIDGKETLNKKYITEGVQRFITEKYSSHYGKNIMLGFIVKDI
                     NIQSNIQKINSLNQNILYTYIDTDMLTVRSDSENNYAVCESKYKVKSKLLLLNHIFYN
                     FSSIIR"
     gene            58391..58807
                     /locus_tag="KNP36_000548"
                     /pseudo
     CDS             58391..58807
                     /locus_tag="KNP36_000548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003455547.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
     gene            58767..61214
                     /locus_tag="KNP36_000549"
                     /pseudo
     CDS             58767..61214
                     /locus_tag="KNP36_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005423199.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
     gene            61354..61776
                     /locus_tag="KNP36_000550"
     CDS             61354..61776
                     /locus_tag="KNP36_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872441.1"
                     /translation="MRLEDIIDKESYEEKYDDLTVEIKKLSKEKKTLKASLINEKSIK
                     ARLREFRKILERNELLEKFDRYVFASIVDKVIVGVINEDGIVDPYKITFVYKTSFDDK
                     QDGHKFINKSPLETYSKDNNDNKKKCSYTNNETLRDCS"
     gene            62314..63348
                     /locus_tag="KNP36_000551"
     CDS             62314..63348
                     /locus_tag="KNP36_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YHYH domain-containing protein"
                     /protein_id="HBF0872442.1"
                     /translation="MFKKKLIAVAMSITMISVGSFSYAHSGRTDSSGGHRDNKNKSGL
                     GSYHYHCGGYPAHLHNNGGCPYTGGGSSSGTTTSVNNEEKQKRSVGEKGYNQGYEDGY
                     KGNYSSSNYSGDYSDTYESKYSEGYEKGKAKLEEEEKVAKETGYNLGLTGAKSNNTYE
                     KEVLKNAYDTGYSTGYNEYKTKKIEEYKAKGIEDSNKDKEKMTFEENIDSEFIDAYNN
                     AYDEIQEQLKNDYTTQGFESAIKGERFDTSTIGNVKYANWFKEGYDNGKVKLPKAKES
                     VYNQGYNEEDFSIPDEMKSIETKLKGVYDEGLEKREEEKSRNATYGVGAGTAAVVAGV
                     VYKKKKRKKI"
     gene            63435..63638
                     /locus_tag="KNP36_000552"
     CDS             63435..63638
                     /locus_tag="KNP36_000552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4236 domain-containing protein"
                     /protein_id="HBF0872443.1"
                     /translation="MGFNFRKSINLGGGLKLNLGKKSVGISAGVKGARVSVNSKGRKS
                     ATLSIPGTGISYTKTSTKKRKPK"
     gene            63809..64969
                     /locus_tag="KNP36_000553"
     CDS             63809..64969
                     /locus_tag="KNP36_000553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp27"
                     /protein_id="HBF0872444.1"
                     /translation="MKLSKILLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGL
                     IADKQNYDIAILINSENGLSDGLSASGLSGAKNAPILLTKKDTIPSETLKRLEKVKEV
                     YLIGGKNSIGASVQKILSDKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAF
                     KGEPDAMSVASIAVRDKSPIVLTDGNTTSFATDGLETYAIGGKVSMSDKLINETKATR
                     IGGVDRYDTNKQIINKFYNGSKEFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSI
                     LKNASKITAIGNIDDVVIKQCLNITNNVGDSNTGIVKDTNSNNTNKPSNEPSSNNPGL
                     TDKSTVYVTPNGKSYHLTKNCSTLKRSKTINKVTLKQAKSQGKIDPCNVCVK"
BASE COUNT        24997 a         7436 c        11045 g        21558 t
ORIGIN      
        1 ataaaaatta tttatctata tgaaaagcat aattattaca tattgactta aaaataactt
       61 atagagatta gaataatttt agtttatata ttttttaaaa ctatacagtt gttataaaaa
      121 gaaaaattgc atacaagtca aaaataagtg ttattttata aaaatacgac aaaaatttta
      181 tttactactt atacaaataa catgcaaata acatataaaa tttaataagt aaaaaaaatg
      241 aaagatataa attatcattt tagtatttta tttagtcgaa gtaaattatt caaatgaaat
      301 atatctcatt tagataaaaa attttagtaa aagtaaaaaa aataatatat ttgttaaaaa
      361 ataaattgac aaaatattca gaaaaaaact tcttgaccta agagagtaaa ataaataaaa
      421 tctaaggtat agagatgaaa tctataaaat tattttaagt ataagttaaa aatatagatg
      481 atgcatttaa gatttataaa aattagagat gcataattat tttagggagg tttttagtat
      541 ggagaaaaaa gaaaaggtag tagaaaaatc aaatgttgaa gtatgtagtc ctgaaattgt
      601 caacagtgtt gaaacattaa gaatgagatt agaagaaatt agattggcac aaaaagaatt
      661 tgcaacattt acgcaagaac aggtagataa gattttctta gctgcttcaa ctgcagctaa
      721 tcaacaaaga atacctctag caaaaatggc agtggaagag actggtatgg gtattgttga
      781 agataaggtt ataaaaaacc attttgcctc agaatatatc tataatgctt ataaagatac
      841 taaaacttgt ggtgtcatag aaaaagatga agcatttggt tttacaagaa ttgctgagcc
      901 agtaggtgtt ttatcagcag ttataccaac aactaatcct acatcaactg caatattcaa
      961 atccctaata gcactaaaaa ctagaaatgg tataattttc tctcctcatc caagagctaa
     1021 aaactgtact atagaagcag ctagagttgt acatgatgca gcagttaagg caggagcacc
     1081 aaaaggactt ataggttggg tagatgttcc ttcgattgaa ttaactaatg ttgtcatggc
     1141 agaggcagac cttatattag ctactggtgg acctggaatg gttaaatctg catactcttc
     1201 aggtaaacca gctgtcggag ttgggcctgg aaatgtacct gcaataatag atgagagtgc
     1261 agatataaaa atggctgtaa gttcaatctt agtatcaaaa tcattcgata atggtatgat
     1321 atgtgcttcc gagcaagctg taatagtacc agaaaaaata tatgaagaag ttaaaaaaga
     1381 atttaaatat cgtggagcac atttcctaaa taaagaagaa actgaaaaag taggaaaagt
     1441 agtaataatt gatggttcat taaatgccag aatagttgga caaccagcac atgtaatagc
     1501 caaaatggcg gatgtagaag ttccaaaaac agctagaata ataattggtg aagtagaatc
     1561 tgttgaatta aatgaacctt ttgcacatga aaaactttct cctgtacttg caatgtacaa
     1621 gtctaaaagt tttgaagatg cagttgctaa agcagaaaaa ttagttgcag atggaggcta
     1681 tggtcataca tcttcattat atgcagactc tataaatcat ccagagagag tagaaaagtt
     1741 tgtaaatgct atgaagactt gtagagtatt agttaatact ccatcatcac aaggtggtat
     1801 aggtgattta tataacttta aattggcacc gtctcttact cttggttgtg gttcttgggg
     1861 tggaaactca gtatctgaaa acgttggagt aaaacatttg cttaatatca agacagtagc
     1921 tgaaaggaga gagaatatgc tttggttcag agcaccagaa aaggtttatt tcaaaaaagg
     1981 atgtttaggt gtagcagcaa gagaatttaa ggatgttatg gataaaaaga aagcatttat
     2041 agtaacagat tctttcctat ataataatgg atatactaag aaattaactg atttattaga
     2101 tgagatggga attaagcata ctacattctt tgatgtagct ccagacccaa cattagcttg
     2161 tgcaagagaa ggagctaaag ctatggctga tttccaacca gatttaataa tagctgtagg
     2221 tggaggaagt gcaatggatg ctggtaagat aatgtgggta atgtatgagc atccagaagt
     2281 agatttccaa gacttagcta tgagatttat ggatataaga aaaagagtat atgtatttcc
     2341 taagatgggt gaaaaagcgt attttgctgc tatcccaact tcagcaggaa ctggttcaga
     2401 agtaactcca tttgcagtta taactgacca agattcaggt gtaaagtacc cattagcaga
     2461 ttatgaatta atgccaaaca tggctataat tgatgctgat atgatgatgg agatgccacc
     2521 aagattaaca gcagcatcag gtgttgatgc tttaacacat gcattagaag catatgtatc
     2581 tatgttaaga actgaaccag ctgacggtct agcactacaa gcaggtaaaa taatatttga
     2641 atatttacct cgtgcatata aaaatggaaa gaatgataaa gaagcaagag aaaaaatggc
     2701 aatggcatct actatggcag gaatgtcttt tgcaaatgcc ttcttaggaa tatgtcactc
     2761 tttagcacat aaattaggtg cattccacca tgttcaacac ggtgttgcaa atgcattatt
     2821 aataaatgaa gtaatcaagt tcaattgtgc agaagctcca aataagatgg gtgcattctc
     2881 acaatacaga tatcctgatt gcatacaaag atatgctgaa tttgcttctt ttgcaggtat
     2941 taaaggaagt acagaccaag aaaaagtaga taatcttata aaagcaatag atgaactaaa
     3001 ggcaaaagta ggtcttccta agactataaa agaggctgga gtagaagaat ctaaattctt
     3061 agaaagattg gatgctatgg ttgaacaagc ttttgatgac caatgtacag gtgctaatcc
     3121 tagataccca ttgatgagtg aattaaaaga gatatatcta aaagtttatt atggtaaata
     3181 atatctattg tgcaacatag gttctattgg gtttgtatat aaattattag atttgaatat
     3241 aaatagagtt ttattagaga cacgtagaag taactataaa taatagatta taatttaaat
     3301 tctaaatgga aatgataaaa agtcagtaat ttaatggtaa tttcgaatat gtgtatttaa
     3361 tcaattaact ttaaaattag tcggaaaatt tttttattac atataatttt aaagcataat
     3421 atataaaaaa ctttatgaaa aaattataaa aatattcaga aaattctatt gactaattta
     3481 tttatcatga tataataagt ttagaaaaga aaaaaattgg ggcctattaa ggccccctta
     3541 ctattttttg atagatttat ttaaaattac tttctcattt tgatttttta tatttattat
     3601 agagtcagta taatccactt caaagttggc aaaagcagag aataaatcta tatctcttaa
     3661 caaatgaatt gtcatacatt gattgttctt atttagcctt agaatcaatg ctcttacaaa
     3721 tggaaattgt attctagaat taaataagtt agaaccatca gtatctatat ctaagctacg
     3781 ataattaata tctataaata tatctacatc ttcattttct tctcttatta ttctgtagtc
     3841 aaaatccaag tttaaattta aattacctaa aatcaataac atttaaatcc tcttttctat
     3901 aaatagtttt agagtgttaa tttaagctct ccatctatta tagatataat tctatctgct
     3961 tttctagcaa tattttcatt atgtgttatt attataagtg tttggttata tttttttata
     4021 gaacttttta gtaaatccat gacttcttct gtagttttac tgtccaaatt tcctgttggt
     4081 tcatctgcta ggattatact tggttttgca gataaagcac gtgcaatagc aactctttgc
     4141 tgttgaccac cagataattg gttgggaaga tgatttttcc tttcattaag acccaataaa
     4201 tttataaggt catcaatata ttctttatct atttttttat tgtctaactt tagtggtaat
     4261 tctatatttt cctttacatt taatacagga attaagttat actgttgaaa gacaaatcct
     4321 accttttgtc ttctatatct tgctaattct ttatctgaaa gacaacatat atctttacca
     4381 tctaccttta tagtaccatt acttggtctt tcaagaccac ctactaaatg tagaaatgta
     4441 cttttcccac ttccacttgg tccaattata gcaacaaatt cgcctttatt tatttttaaa
     4501 tttgcattct ttagtgcatg tacagatgtt tccttttttc cataaatctt acctaagtta
     4561 atagtttcca atataggcat aattattcct cctattctgt aatgtttata gcttcaacta
     4621 tactaatttt atttatcttt cttgatggaa tatatgtagc tagaatacct acaattatat
     4681 ttgctacaac aactagtata tatattttgt aatctattga aaatcccaat ccatatgata
     4741 caaagccctg catataatac attttaaatt gtattataat tcctgacacg atagtaatta
     4801 tacttgagag tacaccatat aatattcctt cataaagtat catattttta aagcctctct
     4861 cagagatacc aatagctctt aacattccaa attcactagt tcttgaagtt aagttataac
     4921 ttatgttgtt tattatgtta agtacactga ttatgaacat tattgctact ataccataac
     4981 tataaatcat agttctagat gtcatcttat cagaattttc tttttctacc atcatatcta
     5041 ctgttgtagt tccaggaact tcacttccaa ttttacctaa aaggttattt atttttttct
     5101 tgtttgcatt ttcattaagg tctgcataaa ctaagttata cttatctaca ccagttaatt
     5161 tttttaggta ttcgctactc gttattacat ctacaccatc atctccagag tacataccat
     5221 tatctgcaaa aggataactt ataatagctc caactttaaa ttcatattct aagtattcat
     5281 aattatcttt tagactttca taaagacctg tatccatccc accctttgga tatttgactt
     5341 ttatagtatc acctactttt atatctacag ctggtgttcc ttcaccagga gtaaaagtct
     5401 ttgtgtattt ctgtgtttta gaaatttctg gtacatatac aatagctaaa ttttcttttt
     5461 tcattttttt caagtttata tttccactta ctaagtattt ttctaatgac tttatcatct
     5521 catcattata accttttagc ttttgcttta gtgtatattt gccagtagtc ttatttttta
     5581 tgaacagagg atttagctta taataaggag ttgaatttat agcttcgtag taatctaatc
     5641 tatttatttt atttacctct attcttgtgt ttaagatact agcagttttg actttgtcaa
     5701 ttccatctat attttttatt ttatctatct gattatcatt aaaccctttt atatctttaa
     5761 aagaagtatt gttaccaatt tcattgagat aaacatttga tagaataaaa tctgcattca
     5821 tatatgtttg ttcttgagta gatttgtttt gcacatctaa aaaagaatat ttataattgt
     5881 cttttatgac gattatacct cctatactca tagataatac aattataatg aacccctttt
     5941 tatttctaaa gatgtttttc gcagatatag attttgttac tgacatattt aaagttaatt
     6001 ttgatattaa ataattaact ttggttacat ttttatcagc tccaaaagtt tttctgatag
     6061 catcaatagg agaaattctt cttattttta agtatgtaaa gaaacttata attagtatta
     6121 ttagtattgt acatgcaatt gataagagaa ttattttatc tggaataaca aaaggtgtaa
     6181 catttatatt tccttcaaat tgaatatttc ctacagacct attaaatatt tgtgcacctc
     6241 ccatacctat acatatacct ataggcattg ctattagagc aagtatgaaa agttcataaa
     6301 gcataagttt gaaaatccta aagttggtgg aaccaatagc tcttaagacg ccatattcct
     6361 gtactctttg gtatattgat ataacataga tactatatat tacaatacca gcaaatagac
     6421 tcatagcaat tgcaacgtat ttacttgaat tatctaaagt accgtttttc atagtagatt
     6481 ctataagcat tgagtttctt cctatacttt tctcatctaa catagcattt tttattatat
     6541 tgtctatgtt tgtatttata tcactgcctt cattaaattc aatataagtt gtaaaatcat
     6601 tcagttctga ttcattgaga ttagaaaaaa tttcacattg tccctttttt ttctctataa
     6661 atctatcttc aaggattcca acaactttaa aagtttctgg attttctttt tgatataatt
     6721 taaaagtaag gttttgattt atctctggtt ttaagcccat actatttaaa atccatttct
     6781 cgactaccac ctcattgcta gcttttggaa atcgaccttt tataagttta gaatgactag
     6841 tcaaataatt tttatttgta tatagtatgt ttataggtaa tttttcatta acatctgtag
     6901 acgcatagta agatgttata cccagatttt taatatcttt gctagatttt atggacttta
     6961 attgattttt ctttatattt ttaaagtata catggtcagt tccaagctct cttttcaatc
     7021 tatctacatc tgcttgctga gcacttcttg agagagtacc aataccaaca acgagtgatg
     7081 tagcaagaat tatactcaca acaattgcta aagacctagc tttataactt tttatatacc
     7141 ttagtactat tttcaaatta tctttcatat ttaccacttc ctttcttaac taaatcaatt
     7201 atatatttat ctaaaatata tagcaaagta agtattttca aattttaagt agttaattgt
     7261 acaaattcat ctgtattttt acaagtttaa ttaatatata tgtaaatttt aactttttac
     7321 ataatttttt taaaatgata taatccctat ataaattgta gaggggaggg gaatcatgga
     7381 taacaatttt gtatttccta tagtaatact aactttgttt atatttagca atcttataat
     7441 gaataagtat aaattttaca aagaattaga catattaaaa agaggcatat taacattttt
     7501 tatatcgtgt tttgcattga ttttatttat ggagggcact aaatatatac aattaaggtt
     7561 aggatatagt tttttacttg aaggagtatt aaatattata ctttttttgg ttttaattat
     7621 tttaagtttt tatacaggct ttaaagttat aagattgata aataataata atgaacagga
     7681 atataaatta caaaaactag atagtaaaat aaatcataag gataatataa ttatcaaatt
     7741 aagaagtcaa aaacatgact atttgaaaca tttgcaagta gtgtattctc tattaaatac
     7801 tgggctagat gaagatgcca aagaatatat aatgaatata tcaaatagct ttaaatcaaa
     7861 aaattcaagg tatggaaaag tatcttattt agatgctata gcttcattaa aatacgagga
     7921 atgtcttgaa aaggatatat cttttgatgt ctacattcaa gattttatgg ataatttaga
     7981 gattgaacct aatgatatga gttcagtact attaaacata atagataatg caatagagtc
     8041 tttgtctact ataaaaaaag aaaagaagta tataagatta catgcatatg aagatgaatt
     8101 tcagtatatt atagctataa aaaataatgg tcctaaaata cataatgttg aaagtatatt
     8161 ttggaatgga tttagtacta aagaaggaca agatagggga tatgggctac atttagttaa
     8221 aaatatatta gataagtatg attatagtat acttgtaaat agtgatgatt ttttaactga
     8281 atttgtaatc ttaatcccaa aatattatta gttaggagga gaaaagtcta tgataaaagt
     8341 tttgatttgt gatgatgata agattgtaag agatgatata gcaaatatag ctaaagagtc
     8401 tggatatgta gattatgtta aaaaagttaa ggatggtata gaggcaattg aatttataaa
     8461 aaatgagaaa atagatttat tgattattga cattgatatg ccatataaaa atgggattga
     8521 ttctgctgaa gaaattcttt ctatagataa ggatatacat atagtatttg tgacgggttt
     8581 cgctgattat agtcttgaaa gctttaaagt gcatcctata gattttgtag ttaaaccatt
     8641 taaaaaagaa aaaatacttg attcaattaa catagcaata gaccatatta actcccataa
     8701 gattgctaat aataatttta tagaagacac cctttttgta tataaaataa ggaagcagat
     8761 acatatgatt aattttgatg atatagttat gtttgagaaa aattcaagag caattaatct
     8821 acacactaaa gatgaagata taataaagtt ttatgagaac tttgatgatt taaaaaaacg
     8881 cctacctcct aatttcttta tgacccatag acaatacata gtaaatctaa gatttataca
     8941 taaggttata cctataaata aatcttcatt agagataagg tttataaatt ttcaagaaaa
     9001 tgccatatta aacaaatctc tagaaaaaga ttttttatat agattttata gggttaaaag
     9061 attctagtga agatagaaga aaaatacttt ttgtgtgata taataagtac cgtaaagata
     9121 atgtataaga gaagtttata taaaaattat ttgtaattat gatttaatct atataaatta
     9181 cagtatagta tatattggac tttctaattt ttttaagaaa gtccaatata ttttagagat
     9241 agtttttata cttataaatt acttaagata ctagggtctt taatcttact atcttcagca
     9301 agtaatagta tcttagacat aatctcagca gttttagggt cttcatcagc gaatggaagg
     9361 aatatcttac ctctactttg agaatgtata ggaagtatat tcaaagcacc catccctttt
     9421 ttatgtacaa taccagaacc catatgcaca gaatactcac ctaaattacc tgctataaga
     9481 gcatgagagc cttcaaaatt gacattgtta atttttaata ataataaaag ttctttagca
     9541 attgctatac gcatctctac agtagaatgg ctagtttcag ggtcaacacc accagcatga
     9601 gcgacactta caacaaggtc tatatcacgc ataacttctg agaatagaat tggaggtata
     9661 gaagctaatt ctaaactttt ataagttttt ctatcaaaaa attctactgt ttcaatagta
     9721 ggaggctcta tatctgctgg tgaaaaccaa tctgcaagtg caaacatctt tgccactata
     9781 ttttctttat aaaatacttt ctgtaatccc tcttcataat cgacagtcca aagctgattt
     9841 ctaagaagtg ctacagtttt ctttggctga atttggtgac cagcatatct gcgagatata
     9901 gttttttcag ataattcatc actgtttatt ctataatact cacggaatac ttgcttaaat
     9961 ggttgaacaa tttgcttact aaataaatca tgttggaact cactccactt accagattca
    10021 aacaaatgaa ctggatgtgc aagttttaat ttattttttg ccgtcaactt ataagtttca
    10081 ccttctatat tgcaaataaa gaacttagac ttatcattat aaacatatcc aatattatca
    10141 tcacataccc atactagatt tttaatcaaa gggcagataa ctggattttt atagatattg
    10201 gcaatttctt taactgtaaa tactatttca tttttcatag cttgttctaa actctgtttt
    10261 gcacgagaat actgactctt taaatctttt tggacagatt taagttcaag tacatatgga
    10321 tgtttagcaa tagcttttgg tatactcttt aaagacttgt tgcctttttg aactttagta
    10381 gatgcttttc cgttttcatc aacatctatc caaattgaag taccatcaat atcttttggt
    10441 ttaaatagat gagcaacttc atttagtttt tcagtctcaa gagcccacat catacgattt
    10501 acatctccaa atccagcact tctagctaga ttttctagcg ctatagtaca agcttttgat
    10561 tcactttcac gacgttgtgc accaaattgc ttgctttctt tagcaaactt ttgaataaat
    10621 tcataacgga aagttgcttc ttttaggtct ccttttttca taggaagtaa agagaaactt
    10681 ctcaatttat cttgatttct atttgtttca atttctttca tcaacatgtc tttatcaagc
    10741 ttaccaagtg tagcatcagc atagagttgt gcacgtctat gagagttacc accactagtt
    10801 atatatttag ctgacttgta aagtatattg aatctttctt ccccaatagt tttatatgaa
    10861 tctaaaaacc aatctacatc aaatgcacca tcaatgaaac tacgtggtga aataggggag
    10921 aatagagcaa cctctgattc tttttgtgca gagaagcctt catttatatg tgcatggaag
    10981 taccaaattg tacttttcag acccttccag tttaaatatt tttcaattat gtttacccat
    11041 tgaggggcat acatagcaga ttctatcaat cttaactcag taatgtcggt atttttaagt
    11101 aaacttttta atttttttga atcatcttct ttagtaggat agcaattttt aagtagagaa
    11161 cttaaaacat ctttttttga ataattgcta ccatatgaat atcctctctg gaaagtttct
    11221 ttaccaagag cgaccaaaat atttacaaaa taatttatac cttcaaagta ttgtatatta
    11281 ttagctagat tagacacttc tgttggcata tcacctctac gtgattcaat ttctataatt
    11341 cggtttgtaa cagtttttaa attatcttta agccaagggt acttttctaa tgtgtcgcca
    11401 gcccatctag gatttgtcaa tgttcttatt atatttgatg cgttgtatcc acttatcatt
    11461 tctctattaa cttgctcttc agtcattaat cctaattcat gtgcacgagc aaacacattt
    11521 atgctagtat agaaaggaaa cttatattct agcaactgat aatttgaaaa cgtagtgtag
    11581 aaaaacttag taaaagaaat atcatcataa ataaacgaat gtgctttatc aagccaatag
    11641 tttaaaatag gggcatttaa agcagggcag tattcatttt gtctgtaata gtttttagta
    11701 aattcaactc tttgtttttt acattgttct atagtcaata agtttctaag tttatagtat
    11761 atttctaaac aatagttaaa tatttcttta tggtcaaact catttagtaa aactcttaaa
    11821 agttttcttg taagtccatt aaatttaagt ttttcaagtt ttgtatatat tttattttgt
    11881 tttttagagt caaggacatt tgaatatata gatgaaaacc aacttttttc tgtttcatta
    11941 tatccacatg tacttatact ataaaataag atatcaagta ttaatttgta atctaagtca
    12001 agttttttac tagtttctct ccaaagctct gctaatggat aattatcaag agtatcatta
    12061 gaaactttat atttaatagg agtcaagtta taagtagaat aacctaaaag tactttgtct
    12121 acattacctg accatctttc aacttcatat tcataatctg cattttcagt aataagttca
    12181 tcaaattttt cataaacttt tattatttta tttatatccg tatcgagaat tttttttgct
    12241 tctttttttg ttgctacaga aacagaatcc tcacgagtag ataaacttat atttgagata
    12301 attttattaa gctttgatga gctattagaa tcatctttaa aatcaaattg ttctggaatt
    12361 tgaactttgt tttcagggtt atatattcca aaaccatttt ctttgcagta atcatttttt
    12421 gctttaccta acaaattatc aattagtatt tgaacttgag atgtattctt tttagattta
    12481 tcaatatcct ctataagtaa aataagctta ttatatagtt cttgtctagc agtattgtct
    12541 tttaataagt ttacaatttc aagacctcca aggcattttt gagaatttga agattttatc
    12601 agtgaagaag caatattttc caaatttgaa tcatcttgtt caagtaaaat ttttattact
    12661 gtttgtctaa tagagcttgt ctttaaagac aatagattgg ttatcttatc taattctaca
    12721 tctgttagct caagctttct aagtagactc aataccgttt ctctattgga aacactctta
    12781 tcacttaaac attccaataa aaattcacgt tgtctatctg tctttggttc atttacaaaa
    12841 ttgactataa gtgaagctct taaatctgaa ctcataagat gacaattttc cataagcaca
    12901 tctataaatt gagcattcat atcgtatgct gttaaagtca tcatacattt aagtatttca
    12961 tgagaagaaa tttcaatcca agtccatgga aatacacttc ctgaaaatga ttttgtcttt
    13021 gaatttaaaa tttctaaagt atgttttaaa ctttcaaatt gttcttttct agcatcaaag
    13081 tctttgtcaa taggagtgtt tgacaagtca aaattagttt ctctgttttg ccaactatag
    13141 tagtagccaa cagaaccttc tacatagaaa tttgtaatta cccatgctag tatctctaaa
    13201 tcatcaccct taatgttttt agatgctata gaatgtttaa aatatgtact ttctgtatgc
    13261 gataaaaagt aaagagctac aagtttttta tatttttcct gacaagaaag taagttttca
    13321 ataagagagt aagagtcata tatgttgtaa gttgcagtag cccataaggc aaaataaatt
    13381 tcaagattat cattgctatt aattgattct atacggaact tttcatcagt caatgattta
    13441 tatgaaagtt ctaaacattt acgtattatt ccaggttttt ggtctgaaaa accaagtcct
    13501 gtccatgtat ccaaggctct tataacagaa ctaaatcgct ctaaattgtt gtccaaaata
    13561 gtttttaaca tgtatattga tgcagaaatt gtaccctcat ctaaactctc tacaatttgc
    13621 tgtctaagtc cttcttgttg tttggctgcc aaaagaagtt tagaaagcat ttcatagcat
    13681 ttatcactat gactcttcat gataccaatt atcatttgtc ttgtaagtag agcagtttga
    13741 ttttctccaa atattacttc ttctaaagca cttattactt tttgatttcc tttgtctatt
    13801 tctagtgcta ttttatcact cattatagag tcatagtaca agaccttatt tggaagagta
    13861 agataatcta taactgaaaa atcataataa attaaatcaa catagtttga aataaacctt
    13921 ataatacctc taaaataatc cacaagttta tttgagcgat accctttacg ataatatcct
    13981 cctgaatatg tataatccat ctttctttta attaattggc aaagttcttc tacttgttca
    14041 gaagtaaata ttaattctaa tgcatttttt aaaggtccag aaaggagctc gtccatattt
    14101 ttaatttcgt agtagtggca attgtagtat ttctttatca tatttaagaa tttgtcttca
    14161 ggttctctat aatagtatga actattttct atgcagtccc aaagagactt tgctaagtcg
    14221 tagtactgtt ttgaagaaga tttagtaaaa ttatttttaa aattttcaat tattttagga
    14281 tttttttcta ctctagtacg ttctaacatt tatgtacctc caaattattt attttaaaac
    14341 attcttccag caagcaaggt aagtcttata aaagtaaata tatctccact tttcagattt
    14401 atagaggaat cgagtttttc aataacatcc tcatttataa gcactttgta gattccatct
    14461 tcaaatgcct gtaacgctac ctctattgcc ttttctacag attgtttatt ctcattgtaa
    14521 atagagccaa atccaacttt tccaatatca gcttgagatt caatttcttc attagttaag
    14581 aagtttatta ttgatttttc tgggattttc tcattatatt caagaacatt tttagataca
    14641 atttcagaga tagcttcttt taggcaattg atgttgtcag atacatcaaa aggggtaagt
    14701 tctagcatag gtttgcgttt gccaacagcc ttaactctaa aataaatttg cataaaatca
    14761 cctcgcaaaa tattaattat gtatttagaa atttaaaaat ttatctattt gttatattat
    14821 atcattttgt gaattattaa tgtgaattat ggaattattt tacaaaaaat agaaaaaaag
    14881 ctatcttaaa gtctaaaaaa gcaataaaag ataactttta actataatta tatagaatta
    14941 taactgtaca tttattaaat tttaatttta gaattatttt tgataactat ctttttttat
    15001 ttataaattt tgctcctaaa tattttttga tatcttcttc aggagaaaag tcatcaataa
    15061 gtatttcttt cccagtgtct tcaaatacta caagaacttc acagtcacct tgtaagaaaa
    15121 attttctaac tgtatcttct ttaacttctc taacttttat tacattcttt ttttcttttt
    15181 caaagtcttt tgtgtaataa cttcccatca tattaattat ttttgtatat ctattcataa
    15241 aatacctcca tatgcgatta aatttaaaaa atatgttata ataattgttt gtattaactt
    15301 aataattata acaaggagta ataataatga ctagtataaa aaataaagat attttaaatt
    15361 gtatagatta ttccattaaa aataagctct ttgacaaact aaatgatgta tataagtcct
    15421 tgccagtagg aaattgttct ggatgtggaa attgttgtat ggagtcagta ggtataaatt
    15481 taattgagtt cttgaatata ttttgttatc ttgaagatag agttgattta aaaaaaagct
    15541 gtataagtaa aatattagat tattattttg aggagtatac aagaaagaac ccatgtccat
    15601 ttaaagatac taataataga tgtttaatat atgaagttag accattaaat tgtaggatgt
    15661 ttggacattg gaaaaaagag gattataata aaaatttaga taatgttatt gagaaaaata
    15721 ataactatag agagttaatg aaaaagcaat atggatttga aataaatgat gaagtagtaa
    15781 attacaggat agattattgt gatagattta ttccaaataa agattattta agtaaatcta
    15841 agagattaag cttttttgat gagcttatga tattagactc aaatatttat tcaagtggaa
    15901 atatagatat agactttagg gatagaggta tagttgaata ttttatagag tcattacttt
    15961 atagaaattt agcatataat gtgaaaataa ggatatctaa agaatacaaa ataagaaaaa
    16021 gaactataga tagaataaaa aggattgttc ttgtatagtt ttatattagt aagtaataaa
    16081 ttgtatcata aatattgtca aaatgaggtg aagaaggtga atcttacaaa agtaaaagga
    16141 aatacctttt ttataaaagg tggcacgaat acaggaatat atgtatttga agataacaca
    16201 gcacttatga tagacccagg gttatgtggt tcaagaccta ggagagtaaa taaagtatta
    16261 gatgaaaata atatacaggt tagatatatt ataaatactc atggtcatga tgaccactat
    16321 ggagcttgta atcaatttaa agaatattat aaagatgtgt gtataatgtc atctgaatac
    16381 gataaattat atatagaaaa tccagaattg ttttcaaagt atattgttgg gggaaagagc
    16441 aatgtattta tggataatat cttaaaaaat aaaatgttgg atgatataaa aatagataaa
    16501 tctatagaag ctggaaaaat tgaattaaac aatgaaatgt ttgatataat tgaatttcag
    16561 ggtcatacac ctggtagtat agctgttttg acgaaggata atgtgatttt tgttggcgat
    16621 ttattgatag gagatgaaat tctatcaaaa tacgatttct tgtttctata tgatatacaa
    16681 gaacaaataa attcattaga aaaattaaaa aatatagatt ttgagtactt agttttaggg
    16741 catggcaagc aagttatatc gaaagaagat tcttataaat taatagaaaa acatttgaat
    16801 gctttaaaaa aatatttata tcaaataaga gagttgcttg tagaaccgaa atctttagaa
    16861 attttattaa aaaacattat aaataacaat aatttaagca ataattataa agagtatcat
    16921 ttttttaaat cttcgttagt atctgtcata agttacttag ttgatttaga agaaataggg
    16981 tatatattgg aaaatggaga attgctttac tatacaaaaa caaaataaat tatgataaaa
    17041 taaagaaggt cataaaaaac aaataaaggg tgagcaatat ggaatacgaa aaatggaatg
    17101 agatactagc accttatgaa catgcagtag aggaattgaa aataaaattt aaaaatataa
    17161 gaaaagaata tttagcaaaa ggtgaatatt ctcccataga gtttgtcaca ggtagaacaa
    17221 aaaaaatatc ttccataata tctaagttaa aaaggataaa tgcaaaagat atagaaactg
    17281 aaattgatga tattgctggt ataagaataa tgtgccagtt tgttgaggat atatatgcta
    17341 tagttgattt gataaaagta agaaatgata tgactataat aggagaaaaa gattatatta
    17401 caaattacaa agatagtggt tatagaagct atcatgttat aataaaatac cctataaact
    17461 ccattgcggg ttcaaaggaa attatatgtg aaatacaaat aagaactctt gcaatgaatt
    17521 tctgggctac aatagaacat tcattaaaat ataaatatga ccattacata cctgagactc
    17581 ttgctgaaag gcttagaaga gcatctgatg ctgcctttct tttagaccaa gaaatgagtg
    17641 aaataagaga ggacataatg aaagctcagg ctatgtacca aatgaagtct atagctatta
    17701 gagatacttt aaatagaata caagagttat atgacttggg tgatacacat aaagctatgc
    17761 agtaccaaag aaaacttgat agaactgaaa cagataaaaa tataactgaa attttggaat
    17821 taaaacaaga aatagatata ttattagagc aatataagga tactaaggta gatgataaag
    17881 tagttcagta aaaactactt gtagaaaatt tgctaaatat taatggggct gcctcttaat
    17941 ggaaaataat ttctaaaaag agacagccta tttagtgtaa ttaagaaagg aatgatatta
    18001 tgagtttgta tgctataggt gatttacatt tttcaacatc agtcaataag ccaatgaata
    18061 tctttggaag taattgggat ggtcatgaaa agaaaattat agataattgg aaagaagttg
    18121 ttaaggaaga agatatggtc ttagtactag gagatacatc ttggggaatt aatttatccg
    18181 aagctaaaaa agatttagat ataataagca aacttccagg tcagaaaata cttataaagg
    18241 gaaatcatga ttactggtgg acaaccgtta caagtttaaa taagctatat gaagacatgc
    18301 gttttattca gacaaatttt tatgaatata aagattatgc aatttgtgga ggtaggggct
    18361 ggatatgtcc taatgatgtt aaatttgatg agactgatga aaaagtttat aaaagagaag
    18421 aacatagact tagactatca ttagaatctg ctcgtaaaag tggtcactca aaaataattg
    18481 tgattactca ttatcctcct acgaatgata aattggaaga atctttattt acaaagttat
    18541 ttgaagaata taatgttgaa aaggtgattt atggtcactt gcatggtaaa gaatctttta
    18601 aaatgggatt gaaggggatt cgaaatggag tagaatatac attagcatct tgtgactata
    18661 cagaatttaa tttaataaaa gttcacgatt aaaaaacata aattggtaaa tactataaga
    18721 tacatgatta aaaataaata tttgagggat ttcggttttg agaaaggaga cacgacttat
    18781 gaggtggata ttagttttta tatttttata tcttattcct ttagtagtga tattcagaaa
    18841 ttacaagaat tttaagaggt cttgtatcta cagtagtatt tatgtggtat tagctacaac
    18901 aataatgata agtaatattt atatgagtgg acttaataaa ataaaagagt ctatgtatta
    18961 tcacaattat atttctgatg agacatatga tgaaaagtat gtatcaaatt ttaaggaaaa
    19021 agaaagtact gatttaaaac aggataataa aaagaatgaa gaaatatcaa ataataaaaa
    19081 tttaaacaac aaacaagata gaaatataca aaataaagaa agtaatgaag aaggaagtaa
    19141 tgatataaaa gaaaagaata attctgatag taatgtttca gtgaataata aatcagaaaa
    19201 acaagaagat aatacaaaag aaaataataa atatacaagt aaagaaaaaa atagtgaaga
    19261 tataaaaaaa atagatatgg aaagtatagg aatttttaag aaagaaattt ataatataga
    19321 aagagcagct ttagttccaa tgagagaatg tataccttac actaaggata tagcaaaaaa
    19381 tataactaaa ttatctagta taaaaaaaga tgttacaaat gccagaaaca agtgtaaaga
    19441 agttgtaaaa gaatatgaaa atatgcagat tccagaactt tctaaggaga agtatacaga
    19501 aacattgagt aatgctagag atgacgtaaa gaaagcatat gagcttagag aaaaatctat
    19561 ggaaagtgct ttgaaattaa taaatactaa aagccctaaa tatataggga agataacaga
    19621 atatcttgat ttatcagata agcagataga aagttttaaa aatagattga acgatttaaa
    19681 agaagaaata aataattcag aaacaaataa tattaattaa taagatttaa agatataagt
    19741 taaaagggag attatgatga ataaacagag tataggaaaa ctaaatatgt tttttatggg
    19801 gattactcaa agaaaccttg ataataggga tttttttatt gagttagagg tgatttttaa
    19861 atctggaaga aaagagttta aaggaattgc aatagaggaa gataataaat ataaatttaa
    19921 ttttaaagga aaatcagatt tatatacgtt taatgagttg cttaagaata tttctaaaga
    19981 ggcagaaaat tatgatggat tagtatttaa atatgttgag cgaggaacta ttgttgtaat
    20041 tgaaggagac aataagaagg taaatgtaaa atatttagat aataaggaag aagtacctaa
    20101 aatagatgaa tttacggcat ctcaaataaa aaacagagat tattatgtaa aagtaggaca
    20161 agcaaatgca cttttaaaag aaattggagt acttacaaaa gatggtaaga taaaaaatga
    20221 taaaataaga aaatacaatc agatagacca ttttgttgaa ttgatagata gtattttaaa
    20281 agaaataaag gataaagact gtataactat cttggattgt gcttgtggaa aatcttactt
    20341 aagctttgtc ttaaattttt atataaaaga agtattgaag aaaaactgtt attttatagg
    20401 aatagattat tcagatgtag ttatagaagc atcaaaaaat atggctaaaa acttgggtta
    20461 taaaaatatg tcatttataa aagaggattt gactaattat acacctaata gggatgttga
    20521 ccttgtaata agtctacatg cttgtgatac agctacagat atggcaatag gtctaggaat
    20581 tagagcaaaa tctgaagcta tagtagtagt accatgttgt cataaggagt tattagggca
    20641 atatagatat gaagctatgg aaccaatatt aaaacatggt gtatttaaag ctagatttgc
    20701 agatttaata actgatggtt taagaacatt gttattggag ggcaatggat atgatacttc
    20761 tgtagtagaa tacatatctc cacttgatac accaaaaaat ttaatgataa gagcgataaa
    20821 aactaaaacg aataatgaca aagcattaaa agaatataaa gaactgaaat cacaatttgg
    20881 agtggaacca accttagaaa aacttatata ttagttaaaa atgtaaaatt tacgaaaagc
    20941 ttgcttaaat atgcaagctt tttggtatta tataggtata gtcatatcca gagttttgat
    21001 ttataattaa agctgtgcta taatatttga ttaatcaaat caataaatgt tacatggagg
    21061 taaaaatgaa caaattgaat atatgtattg atatagatgg aacaataaca agcccttatc
    21121 attttcttcc atacctaaat gatatcttta ataaaaatat aactgaagca gagtgtataa
    21181 cacataattg ggaagaattg tatggttcgg gaataagaga tgtgtatgcg gagtttaata
    21241 ataagtatat acactcatat gatgaagcaa agattgtaga gggtgctaca gaggtaatta
    21301 gcacattatc taaaggacat aatttatctt ttgtaacggc tagacatgag tgtttaactg
    21361 atgtaactaa aaattggcta tcgagacaag gattttcaga tatagatgtt tacttattag
    21421 gaagtgatta taaagttgaa aaggcaagag aactgagttg tgacatattt atagaagata
    21481 atcctttaaa ctcagtgcaa ctagctgatg atggtgttaa agtaatactt ctggatacta
    21541 actataataa agatgttaaa catcaaaata tagttagagt tagtaattgg atagatattg
    21601 aaaagattat aaaacaaggt atttaaagat ttgtagattg aaagggggag catatgatag
    21661 atttaaaaat tgaaaataga aaaggaaaaa tccatgtaaa gagcagtgaa ataaaagaca
    21721 ttttagaatt acgtccagac ttcgaatatg tacaagatat atcaaatact ataaatcaag
    21781 aaaatatatt ggtatttgat tgccagttga caggaaattc ttttgatatg gatgatttag
    21841 atatagaaga aatattggaa gagttaggtg aagaaataga tgagtcttat ttcagtgttt
    21901 tatttgaaga tgtaagagcg tatttaaaag atgctactga tgagatagaa gcagacttac
    21961 aggataatta cttatttgat aatttgagat gttattttga tatatacaat ataaatcaag
    22021 aatttacaga ttttaagttt gtatttttag tttcttttaa agatataaaa atttcttcat
    22081 tagcaaacct agctaagatt gtttctaaga gacagcttat aggtgcatct aagttttata
    22141 gttaaaatga aatattatta taataaaagc tagtaacctt gtaaaaatat aggttactag
    22201 ttttttattt attcattttc acaaaatttc agaaaactat ttacattcta aaaaaagtaa
    22261 tgtatattaa acataatgta cattataatg gataaaaagt ttctattaaa ttactaagtt
    22321 tatttaataa tcaaaataat ttatcttata ttagtatgta ttagggggta tttatgcaaa
    22381 gtttaaatga aataattgct gaaaatttaa aaaagataag gaaagaaaaa catcttagtt
    22441 tagacaagat tgcacaactt agtggtgtaa gtaagagtat gctatctcaa attgaaaagt
    22501 gtgaggtaaa tcctactata tctactttga agaaaataac taatgggcta aaaatttcat
    22561 ttacatcatt gatggagagg caggaaagtg acatagaatt gattcaaaaa agtgatatag
    22621 accattttat tgaagataat ggaaagtata taagttatcc aatatttcca tttgactcca
    22681 aaagaagatt tgagatattt atgattgaaa tagaagaagg tggaaattta gattcaaatg
    22741 ctgaacttcc aggaacacaa gagtttataa ctgtttttag tggcgaagta accattaaaa
    22801 taaatggaga agattacatt gtatctagtg gaaattctat aagatttaaa gctgatgtat
    22861 cacatatata tagaaactca ggcaaaggta tagctaaaat gagtatggta gtatattata
    22921 tataaataat ttaatggaat tagagtgata tttagatgat tttaggtatg aagatatatt
    22981 atatttaagt tataggagtg tgatttatgg atgaataata aaaaagcagt ttttttcttt
    23041 tgcagtgatt taaagaaaga cccagtagcc agtaatgtga taaaatgttg tgaagaaata
    23101 atggatttaa atcaaactga tattgttatt gatgataatt ttgtattaga gtttaaggat
    23161 aaaaacaata acttatttca ttttgtaaaa acaaaagatg taataagtca taattataaa
    23221 tattatcttc caattttaaa tagacatttt agagattatg attttgcagg agttgtaaat
    23281 tggcatgagg gagaaaatgc tccagaacat atcctaacag ctcatacaat tggagatgtt
    23341 ccaacaggag aatttggaaa ttcaaatcca agatacttta aaaatctaat caatgctatt
    23401 gaggatataa aaaatgaaaa tctacttgat gaatttacta cattaacaga agcaactcac
    23461 tggtctggaa caacatatgg tgaagaatct aaattaatta cagaatattc tgtacctatg
    23521 ttggatattg agataggaag tagtagtgat agttttaata atagtatagc aatacaggta
    23581 ttggcaaaat cattaattag agtatttgat tgtgatgaac ctttgaagac tttgttatgt
    23641 gttggagggg tacattttga gaaatctttc tcagatatta taaaaaataa agaatataac
    23701 atatcaattg gacatgtatt gccaaatcaa tggattgtaa gtggaatgta tgatgatgaa
    23761 tctggatttg agaaactaga aaagtgtata aatagcattg aaggaggaat tgattgtata
    23821 gtttttcatg ataaattaaa aggtacctat aaagagcaat gccgtaaact aggtgaaaaa
    23881 cttaatgtac ctgtatttaa acataaaata ttaaaaaatc caaaagactt acctatatgg
    23941 tagtcttata cagttaatat aacaataagt cggattaatt tttaagcgag gtcaaaaatg
    24001 atattatctt attttgcatt attaattaga gtagtgctat tagcttttga aagagtagtt
    24061 gtaagattat taggtgatga agaaggagat atttataaaa atatagcttc atcatttcta
    24121 tttttcttta tagggggagt atgtttactt ccatttagca taatggatag agttagtgat
    24181 tggtcgtttt taataccatg ttatataagt agtttagtct attcaattgg ttcagtagcg
    24241 tatgtaacgt ctttagcaac tggggaagtt tcacttgtta ctccaataaa tagtttaaat
    24301 tcattgtttt tactgctttt atcagttata tttttaggtg aaggtttaag tttagcaaaa
    24361 gttgcaggaa tcataattat gattggtgga gtgtttatat taaaaaaagt aagttctttt
    24421 ttaaagaatg tctctgtaat ttttaacaat ttaccatgta gattaatgtt tttatacata
    24481 tttttgcagt cagtaggaag agtattggat aaggcttttt ttgtacaagt atctcctata
    24541 ttatattcaa ctatactgta ttttttcgta ggtttaaatt tatttatctt tttagcattt
    24601 aaaaagaaac aaaaaataat ttgtgagatt tttactaata aaaaggggct ttcaatttta
    24661 agtggtgcta ttaatggata ttcttattta gcattattaa ttgctttaaa taatctagaa
    24721 cttagtatag cagagccatt ttctcaagta tctatgataa taactttaat acttgctcat
    24781 tttatattca aagaaaatat aaaagaaaaa ataccaggtt caattttgat actaattggt
    24841 gggtggctac tgttacttta attgacataa aaaatgaatt ataaaggtgc tattagttag
    24901 tatcagaaaa tttaaaaaag tattgacaat tcttttaggc aaatgttaat ataataatac
    24961 aaaatagtat aaatagaaga catgttactg gtaatgcagg caggatcgaa tatattgctt
    25021 tgatttttca aggtgtttat ataggttctg ccttttttgc atcttgaatg gccattcata
    25081 aaaaattatg gagaaggaga ttacaagatg aattataaaa aaactgccat tgacattatt
    25141 gaacaagttg gtggttcaaa aaatatttta gctttagaac actgttcaac tagactacgc
    25201 tttaagttga ttgatagaag taaagtcaat caagatgctt taaaaaaagt acaaggtgtt
    25261 atgagtatag ttaatggggc acaatttcaa gttgtcattg gaaatagtgt tgttgatgtg
    25321 tatgatgaaa ttttaaaagt ttgcccttta gatacaaatg atagtactgt aaaaactgaa
    25381 gaaaaaataa acttaggaac aagatttata gaatttatta ttaatatttt tcaaccactg
    25441 atttttgcta ttgcaggagc tggtatttta aaatcactgt tgatgttatt agcaatgttt
    25501 aatattttaa aatcagattc tactatatat acattattag ttgctatttc agatgcaaca
    25561 ttctatttcc tacctcttat ggtagctgta actactgcca atgtattgaa atgtaatcgt
    25621 ttagtagcta ttgccgctgt aggatactta ttgcttccag caacaacaac tgctttaagt
    25681 gaaggtgttg aactatttgg atttacaatt ccaaacattg cctataatgc acaggttttc
    25741 ccggctatct tatgtgtgtc tttcttggca acaatggaga aaatttttaa caagtattca
    25801 ccaaaaccaa ttcgaacttt ctttgttcct atgatgtctt tggcaattac tgttccaatt
    25861 actctaacta ttttaggtcc tttaggatat aacgttggta caatttttac aaccattatt
    25921 ttattcttat ataacaaaat gggattctta gttgtaggat tacttgctgc ttttcttcca
    25981 tttatggttg caacaggaat gcacaaagca ctaatacctt attcaattaa tacaattgga
    26041 aagttgggtt atgaagcttt atatatgaca tcttcattag cccacaatat ttctgaaagt
    26101 ggtgcttgtt ttgcagtagc cttgcgaaca aaagatgaaa cattaaaaca aacagcatta
    26161 tctgcaggaa tttctgcctt gatgggaatt acagagccag ctttatatgg tattacctta
    26221 caacataaaa gagcaatgtt aggtgttgta ttctcaagtg caatttctgg taccttttta
    26281 ggattatttg cagtaaaagg atttgtaatt gttggatcag ggcttgccag tatgagtatg
    26341 tttattgacc caaacaatgg aaacaatttg atttttgcga gtattggttt tgttattgca
    26401 atattaggct cgtttattat tacactgatt atttggaagg aagatacaaa tacagtagag
    26461 tcatcaattg gagatgttgt tgaagaagag ctagaagaag aaaaagaagt aaatatctta
    26521 gtaactccag tagaaggaaa agtaatagat ttaagtaagg ttaatgatga actatttgca
    26581 agtaagactt tgggagatgg agttgcaatt ataccaacca atggaaattt atacgcacct
    26641 tgtgattcag aagttgtgat gttatttgaa acaaaacatg caattggttt aagaacaaaa
    26701 aatggggctg agattttgat tcatattgga ataaatactg taagtatgaa tggagatgga
    26761 tttaaaacat ttgttaagac aggcgataat gtaaaagaag gagatttatt aattcaattt
    26821 gatttagaca aaatctcaca tgctaattta gattcaactg ttatgattgt aaacaataat
    26881 ggagcagatt atgcttataa agtgttaaac cagtcttatg gcaatgtaaa aaaaggaagt
    26941 atcttgtttg atgtaaaggg aggaatataa atatgagaaa atttccagaa ggatttcttt
    27001 ggggaggagc tacagctgct aatcaatttg aaggtggttg gaatttaggt gggaaagggt
    27061 ggtctgtatc agatgtagca aaggcacact ttgatgcaga tgtgaaagat tataaatcta
    27121 ataatgaaat cacaacaaaa gatatagaag aaggattagc acatcctgaa gatgaagtaa
    27181 attatccaaa acgtcatggt agtgattttt atcatcacta taaagaagat attgctctaa
    27241 tggcagaaat gggatttaag acatatcgaa tgagtattgc ttggtctcgt atttttccaa
    27301 atggagatga taaagagcca aatgaagaag gtttacagtt ttatgatgat gtatttgatg
    27361 agttgataag ttatggaatt gaaccacttg ttactatgtc acattatgaa ccaccattaa
    27421 atatcgtttt aaactatgat ggatggtatt cacgacaagt tatcaatatg tttgttaggt
    27481 atgtagaaac tatctgtgaa agatataaaa acaaagtgaa atattggctt acatttaatg
    27541 aagttgattc tatgattcgt catccgtaca ctactggtgg tttagttcga gaccgtttta
    27601 aggataaaaa ctttgaggaa gttatttttc aagctatgca tcatcaattt gtagctagtg
    27661 ccattgcaac aaaaatttgc catgagatta ttccaaattc aaaagtaggg tgtatgttaa
    27721 caaaattaac gtattatcca tatacatgta gaccagaaga tgttttggca actcaacaaa
    27781 aaatgagaag tatttatgca tatagtgata cgcaggtttt tggtgagtat ccagtatatt
    27841 tactgtcgta ttttaaaaat aataacattc aaatagtaaa agaagaacat gatgatgaaa
    27901 ttatgaaaaa gtatccagta gattttattt cattctctta ctatatgtct tcttgtgagg
    27961 cagctgatac aactggatta gatattacac ctgggaatac gttattagct gtaaaaaatc
    28021 cttatttaga aatgagtgaa tggggttggc aaattgattc aataggtcta cgtatatctt
    28081 tgattgaatt atatgataga tacagaaagc ctttatttat agttgaaaat ggattgggag
    28141 ctaaagatat tttaactgaa gataaaaaag ttcatgacca atatagaatt aattatttaa
    28201 aagaacactt taaatgtatg ttagatgcga ttatcgaaga tggcgttgaa ctttggggat
    28261 atacttcatg gggttgtatt gatttggtca gtgaatcaac gaaacaaatg tcaaaacgtt
    28321 atggatatat ttatgtggat gctgatgact atggaaaggg gacatataat cgatataaga
    28381 aagatagttt ttattggtat aaaaaggtaa ttgaaaataa tagtatagat tttaaatgac
    28441 caatagaagg tgagcaaata aaatgaacta cataataaag aaagttttga actcgagcgt
    28501 tgttttagtt catgatgcaa agtataatga atttattttg ctagggaaag gaattggata
    28561 tggtaaaaaa acaggagaat atatttgtgg ttccaatgat aatcaaatgt ttgtccctgt
    28621 tgaaaataca aaatcaaaac aatttttaga attaatggat gatattcctg tcgacatttt
    28681 aaagataaca caggaaataa tagtagaggc agaaaagtta ttgaactcat cttttaataa
    28741 aaacttatac ttaatattag cagaccattt taactttgca attgaaagga tgcgtaaagg
    28801 aataaaaatt acaaatcgag tattttggga aataaaaaat tattatccaa atgagtttaa
    28861 ggttggaatg gttgcaattt atatggtaga ggagagattg ggcattcaat taccagagga
    28921 agaagcagct aacattgctt tccattttgc aaatgctatg gcttcagatg gaaattcata
    28981 tgatacgatt aagtatgcca aagtaattgg agaaataatt aatatttttg ttttttcttt
    29041 gaatagaacc ttagataaaa agagtatgca ttatatgaga tttataacac atataaaatt
    29101 ttttgtggaa agattttttt cagatagtat gttaagcagt ggtgatgatt tattatttaa
    29161 tcaaatgaaa aggtcaaatc caaaagaaat gttaattgca ttaaaagtta gagatttttt
    29221 agaaaagaaa tatggaaaaa agttaacaaa tgaggaaata gctttcttgg ttgtacatat
    29281 cgcacgagtt aagcaataga gtgaattact aatattatct tatacgtcta catggtagaa
    29341 aattgaaaga aggtaaagta tataaagaaa ctgagacata ttattttgtt gttcattatg
    29401 tttattttat gagtgtatcc tgttaaaaat ttaagttaat atttataatt aaaatataca
    29461 aatagttaaa ataagtttat gtggttatga atttatttta actatttttt tgtttaatgg
    29521 aaaatatgtt ttataactag aattttattt ttaattaatt ataatacaaa aaactttata
    29581 aaatcttcag aatttcttaa agaatatgta agtaacataa gatatattat atttagttgg
    29641 taatataaag ggggcaatat ttatgaagaa taaaaaattc aatgttataa cactgataat
    29701 acttgataat catatttatg ccattaataa agagcagatt agtactaatt caaaaagaat
    29761 ttactttgaa aaaagtcgat ttttcagtga ttataagtga ataaatatat ataaacattt
    29821 aataaattta gaagttaaat gttttaatac gaaaggatac acatatgata aatttagaag
    29881 aaaagtattt aacacgaaaa gacacatata tgataaaaat tctagaatac aatgggcata
    29941 ttcgaaactg gaaagttctt tgtgaagaac ttggaatcga ttcttcatta tgtagagatg
    30001 agcgtgaacg agcaatttta gtggaagcat ataagacatg gggatatgat atggcaaatc
    30061 acatgcatgg aatgtttgct tttgcattat gggatactgt ggaaaagaaa ctcttctgcc
    30121 taagagacca gtttggggta aaacctttct attattatga gactgaaaat gggaagcttc
    30181 tctatggttc atctattcgt aagattatgg agcaaccagg atttgtgaaa gagttaaatg
    30241 aagacatgtt acagatttat atgtctttca catatgtagc aggtgaaaat acattcttcc
    30301 gtggagtaaa gaagcttatg ccaggacatt accttgtcta tcagaataaa acagtatgta
    30361 ttggtcgtta ttggaaacct gaatttcatc ctgaccacag caagtctatt gaggaatgga
    30421 cggatgaaat tcatacaaca cttcagaaaa ttatgccaga ggtaaaatca gagaatgaaa
    30481 ctgcagagtt attcctatca ggaggtgttg attcatctta tatattggca atgtcagata
    30541 tagaaaaaac aggttcatgt ggttatgagg aagagcgttt tgatgaatca aaattagcac
    30601 aacagacagc taatattctt gggtgtaaaa attcgagata tataattaca cctgaagagt
    30661 attttgcgtc agtaccttat gtaatgtacc atatggagca accaactgga gatgcatctg
    30721 ctatcgtttt tgctattgga tgcaaggcag cagctgaaaa cacaaatatc tgttactctg
    30781 gagaaggagc agatgagttt tttggtggat ataatatata ccataaggca gagtgttatg
    30841 gagagaattt gaagacattt tatattggaa atacaaacat tatgaatgag ggtgagaaaa
    30901 gaaaaattct taagaaatac aatcctgatg tgcttcctat tgaagtggta aaaggaattt
    30961 atgaagaaac agaagaacta gatacactta ctaacatgtc aaatgtagat attcaaatat
    31021 ggttggaagg agatatttat tttaatatag ataaaatgag tactgcagta ggattggaag
    31081 tcagaatgcc tcttacagat acaagaatat ttgatattgc atccagaata ccatcagaat
    31141 ataaagtgaa aggaaaagag aataaaattg cctttcgtac agctgcatca aaaacattac
    31201 cagaagagat tgcttttaga aataaattag gatttattgt gccaattcgt atatggatgg
    31261 ctgatgaccg atataataag gatatccgag ataaattcaa tagtgagata gcagataaat
    31321 tctttaacat agatgagatt aatgagattt ttaatgacta cattagtgga aactctgata
    31381 attggagaaa gatttggatg atttacacat tcctagtgtg gtatgaaatc tattttgtaa
    31441 aatgttaata caagaggaag aatcacctga aataccattc aggtgattct taatgtttta
    31501 taattttact tgctaattct tatgtctaac tcttaatggt atatcaagtt tttttgccag
    31561 ttgtttagat tcttctattt cttctggaga tatttcatct actactgaaa aagctacttc
    31621 ttttatatat tttttgcaat ctcttgcaaa atctaacata taatcaaatg atttttctcc
    31681 aaactttggt tgagtaactc tattataagc ttctttattt ggggcattaa gacttattga
    31741 tactgcatct ataacatttt ttaacagaat agctgttttt ttgttatgta ttaaatcact
    31801 tagaccattt gtatttattc ttatctttat gctacttttt tcttttataa actttgctat
    31861 ctctatcaat tcatttattc tcattaatgg ttcgccatat ccacaaaata cgatttcatc
    31921 atagtcgtct aaattgtatt tattgaaggc ttcttttact tcatctacac ttggctcatg
    31981 ctccaaccat aaactaccac tatttgcaac ttcatctttt tcgtttctta tacaaaaaac
    32041 acaactacat ggacatgtat tagttatatt tacatagata ctattttcaa ttgtatataa
    32101 gatattcata attttccctc cataaattta aattcttaat taaaataacg ttttttaaaa
    32161 tcaagtttat caagtgccat acctaagatt ataaaaacaa taaaacttcc tattggctgt
    32221 aataagccaa gtaagctcat tacaaatgca cttgtaaaac ttccaataat tataccttca
    32281 gcaaacatgt ataaaactaa tcctactata cctgctacaa ccgaagcaac tatatttctc
    32341 ttatttatta tcttgtcact tttagaagtg aaaaataata caagtattgg ttttatgatt
    32401 atagttggta ttacccagat agcagcacct gtagataaat cagctagacc agcaccaatt
    32461 gcagaagcag ctatagcata gtttgttggc aaaatagttg cagctagata aataaaagca
    32521 tctcctatat gaacatatcc attgtttcca ccaactggaa tatgtaatat atatgctatt
    32581 gtcaggcata ttatggatgc aaataatgct gaagtaacaa tataggtagt ttttttagaa
    32641 gtaactttat tcattttttc caatatactc cctccctaaa aatccagagc taacataatt
    32701 gttatgtttt cttataaata tattaatatt aatcatacaa ttttcatagt ttgttaggtg
    32761 ttttttttgt aaaatacaga ttgtacccat tcaaatgtat ataattagaa aagtaaaaat
    32821 aggtaaaatg tatagagtag gagtagttag aataagttaa tataaattta atttggtatg
    32881 aataagaaga gtacaagttt aatataaaaa ataatataag agagtctact caatatatac
    32941 tgagctgact ctcttatatt tgggaaatta aaggctattt tgttagataa tagctaatta
    33001 atgaaaaaat atatttataa aatactaatt tactctatta gtagcagttc ctgtttttat
    33061 aacttctaca gcactactta aactagaata aactatattt tcaatcgctg tactagtgaa
    33121 gaaaccaagg tgatgagtga atataacttg ttccatagaa agaagtttat ttatttctgg
    33181 gtcagttaat tctccaggat tcattttttt gtttaagaac aatccttcag tttcaaatgt
    33241 atcaagggca gcagctctaa tttttcctga ctctagtgct tctattaaat cccctgtatt
    33301 aattaaacca ccacggccag tatttactat gtaagctcca tccttcatta tagctagagt
    33361 atctttattt atcatatgtt ttgttccttc aagtaaagga gtatgtaatg ttataaggtc
    33421 agcttctttt agaaggtctt ctaaagaatc tttgtaagtt aatatatcat ttaaatcact
    33481 atttggatat tggtcaaatg caattacatt agctcctagg cctttgaata attttgcaga
    33541 agtagcacct atttttcctg tacctataac accaactgta atagatctaa cttctgttcc
    33601 aagaagttca gctatccaac ggtaatcacc ttcacagact tttttcttta ctagaggagt
    33661 ctttcttaaa aggttcatag cttgagtaac agctaattca gctattgcat taggtgaata
    33721 agaaggaacg tttgtaacga taagtccatt ttcattaact aaatcaaaat gtatcatgtc
    33781 aacccctgca gttcttgaag ctataacttt aaccccagca tcttttaaag tttcataaat
    33841 ataaggatta tctatatagt tagtttgttg tatagatata ccatcatacc ctttagcttt
    33901 aactacattt tcttcagtca tgttttcagg ataaatatcc acttgaacat ccttatgttc
    33961 ttcagaccat ttttttatta ctggttcttc ataatcgcgt gctccaaata ctagtatttt
    34021 catatcaata ccctcctgta attattaaat tattatggta atttttcatt tagaaataat
    34081 atgtagcata taaggttata ttttttatac aaaattttta aggttaaaaa tttagttttg
    34141 aaattgtttt ccctgtgtta ttttgatatt tagtaatttt ttatttaatg taataattac
    34201 tctaaaattt atcaaagaaa ttgttatttt ttagattaaa tattattaaa aaattatcta
    34261 agtttgaaat tagttaacta acttgctgat taattacaat gataacatgt gtttttgagt
    34321 ttagcaatga aaactttttt tgaaatgtca agctttttca taaaaaaata tataaaaaaa
    34381 acttttataa gcatagaaag aatagcaaaa tgcaatggat agtggcaaga tgccacgata
    34441 tgaaaaagat tattcaattg catattgtta aaaaacattc aaatcaagcg atattttgat
    34501 taaatataaa gttggcacga taaatgctta acaatatagg tgtaagacaa taaaacaata
    34561 aaaaataatt ttaataattt ttaagttatt ttagataaga ttaggaactt tgacatcaga
    34621 cagttaatat cagaaaaaag tattttatga gtgatttaat cgaaatttta taattgatac
    34681 tattaaggag gaaaacgtta tgcttttaga aggagttaaa gtagtagaac tttcaagttt
    34741 catcgcagca ccatgttgtg caaaaatgtt aggtgactgg ggtgcagagg ttattaagat
    34801 tgaacctata gaaggtgatg gaataagagt tatgggtgga acatttaaat ctccagcatc
    34861 agatgatgaa aaccctatgt ttgaattaga aaatggaaat aaaaagggtg taagtattaa
    34921 tgtaaaatca aaagaaggag tagaaatatt acataaatta ttatcagaag cagacatatt
    34981 tgtaactaat gttagagttc aagcattaga aaaaatgggt atagcttatg accaaataaa
    35041 agataagtat ccaggattaa tattctctca aatattagga tatggtgaaa aaggaccttt
    35101 aaaagataaa ccaggatttg actatactgc atacttcgca agaggaggag ttagccaatc
    35161 tgttatggaa aaaggaacat ctccagcaaa tacagcagca ggatttggtg accactatgc
    35221 aggtctagca ctagcagcag gaagtttagc agcattacat aaaaaagctc aaactggtaa
    35281 aggtgagaga gtaacagtaa gtcttttcca tacagctata tatggaatgg gaacaatgat
    35341 aacaacagca caatacggaa atgaaatgcc tttatcaaga gaaaatccaa acagcccatt
    35401 aatgactaca tataaatgta aagatggaag atggattcaa ttagctttaa tacaatacaa
    35461 caagtggtta ggcaaattct gtaaggttat aaatagagaa tatatattag aagatgatag
    35521 atataataac atagattcaa tggttaatca tgttgaagat ttagttaaga tagttggaga
    35581 agctatgtta gaaaaaacat tagacgagtg gtcagcttta ttagaagaag cagacttacc
    35641 atttgaaaaa attcaaagct gtgaagattt attagatgac gaacaagctt gggcaaatga
    35701 cttcttattt aagaaaacat acgatagcgg aaatacaggt gtcttagtta atactccagt
    35761 tatgtttaga aatgaaggaa ttaaagaata tacaccagca ccaaaagtag gtcaacatac
    35821 tgtagaagta ttaaaatctt taggctacga tgaagagaaa ataaataact ttaaagatag
    35881 taaagttgta agatattaat tagtaattct agatttttta aaaggagaat gctaaagatg
    35941 tacacaatgg gattagatat aggttcaact gcatcaaagg gagtaatctt aaagaatggg
    36001 gaagatattg tagcttctga aacaatatcc tctggtactg ggactactgg accatcaaga
    36061 gttttagaaa aattatatgg caagacaggt cttgcaagag aagatattaa aaaagttgta
    36121 gttacaggat atggaagaat gaactattca gatgctgata agcaaataag tgaattaagc
    36181 tgtcatgcta gaggggtaaa tttcataatt ccagagacaa gaaccattat tgacataggt
    36241 ggtcaagatg caaaggtatt aaaattagat aataatggaa gactattaaa ctttcttatg
    36301 aatgacaaat gtgctgcagg tacaggaaga tttttagatg taatggcaaa aataatagag
    36361 gttgatgtat ctgaactcgg aagtatatct atgaattctc aaaatgaagt atcaataagc
    36421 agtacatgta cagtatttgc agagtctgag gttatatcac atttatctga aaatgcaaaa
    36481 attgaagata tagtggcagg tattcatact tcagtagcaa agagagtttc tagcctagta
    36541 aaaagaatag gagtacaaag aaatgtagtt atggttggtg gagttgctag aaatagtggt
    36601 attgtaagag ctatggcaag agaaatcaac acagaaatta ttgtacctga tatacctcaa
    36661 ttaactggtg ctttaggagc agcgttatat gcttttgatg aagcaaaaga atcacaaaaa
    36721 gaagtgaaaa atatataaaa agagggatga aaatgtctga aaaaaaagaa gctagagtag
    36781 taattaatga tttattagct gaacaatatg caaatgcatt taaagctaaa gaagaaggaa
    36841 gacctgtagg ttggtcaaca tcagtatttc ctcaagagtt agcagaagta tttgacttaa
    36901 acgtattata tccagaaaac caagcagctg gagtagcagc taaaaaaggt tctttagaat
    36961 tatgtgaaat agctgaatct aaaggatatt ctattgacct atgtgcatat gcaagaacaa
    37021 attttggtct tttagaaaat ggtggatgtg aagctttgga tatgccagct ccagatttcc
    37081 tactttgctg taacaatata tgtaaccaag ttataaaatg gtatgaaaat atttcaagag
    37141 aattagatat acctttaata atgattgata caactttcaa taatgaagac gaagttactc
    37201 aatcaagaat agattatatt aaagctcaat ttgaagaagc tataaaacaa ctagaaatta
    37261 tatcaggaaa gaaatttgac cctaagaagt ttgaagaagt aatgaaaata tcagctgaaa
    37321 acggaagact atggaagtat tctatgagtt taccagcaga ttcttctcct tctccaatga
    37381 atggatttga cttatttact tacatggctg taatagtttg tgctagaggt aaaaaagaaa
    37441 ctacagaagc atttaagtta cttatagaag aattagagga caacatgaaa actggtaaat
    37501 cttctttcag aggggaagaa aaatacagaa taatgatgga aggtatacct tgttggccat
    37561 atataggata caagatgaaa acattagcta aatttggagt taacatgaca ggtagtgttt
    37621 acccacatgc ttgggcatta caatatgaag ttaatgattt agatggaatg gcagtagcat
    37681 atagtactat gtttaacaat gtaaacctag accgtatgac aaaatataga gttgattctt
    37741 tagtagaggg taaatgtgat ggagcattct atcatatgaa cagaagctgt aaacttatga
    37801 gtttaataca atatgaaatg caaagaagag cagctgaaga aactggatta ccatatgctg
    37861 gatttgatgg tgaccaagca gaccctagag ctttcactaa tgctcaattt gaaacaagaa
    37921 ttcaaggttt agttgaagta atggaagaaa gaaaaaaact taatagaggt gagatataat
    37981 ggaagctatt ttatctaaaa tgaaagaagt agttgaaaat ccaaatgcgg ctgtaaaaaa
    38041 atataaaagt gaaactggta aaaaagctat aggttgtttc ccagtttatt gcccagaaga
    38101 aattatacat gcagctggaa tgcttccagt tggtatatgg ggagggcaaa cagaattaga
    38161 tttagctaaa caatatttcc ctgcatttgc atgttcaata atgcaatcat gtttagaata
    38221 tggattaaaa ggtgcttatg atgaattatc tggagttatt ataccaggta tgtgtgatac
    38281 actaatttgt ttaggacaaa actggaaatc agcagtacct catataaaat atatatcatt
    38341 agtacaccca caaaatagaa aacttgaagc tggtgtaaaa tacttaatca gtgagtacaa
    38401 aggcgtaaaa agagaacttg aagaaatttg tggatatgaa atagaagaag caaaaattca
    38461 tgaaagtata gaagtttaca atgaacatag aaaaactatg agagactttg ttgaagtagc
    38521 ttataaacat tctaatacta taaaaccatc aataagaagc ttagtaatta agagtgggtt
    38581 ctttatgaga aaagaagaac atactgagct agtgaaagat ttaatagcaa aattaaatgc
    38641 tatgccagaa gaagtctgtt ctggaaagaa agttttatta acaggtatat tagctgattc
    38701 taaagatata ttagacattt tagaagacaa caatatatca gttgtagctg acgacttagc
    38761 acaagaaaca agacaattca gaacagatgt accagcaggt gatgatgcgt tagaaagatt
    38821 agcaagacaa tggtcaaaca tagaaggatg ttcattagct tatgacccta agaaaaaacg
    38881 tgggtcactt atagtagatg aagttaaaaa gaaagatata gatggtgtta tcttctgtat
    38941 gatgaaattc tgtgacccag aagaatacga ttatccttta gttagaaaag atatagaaga
    39001 tagtggaata cctactttat atgttgaaat cgaccaacaa actcagaata atgaacaagc
    39061 cagaactcgt attcaaactt ttgctgagat gatgagttta gcgtaagttc attaaaataa
    39121 atttactata aaatatgaaa attggaggaa gctatgttat ataacaaaga acaagaactt
    39181 ttaagaaaag cagtaagaga ttttgttagt aaagaattag atactttacc agcagaaatg
    39241 gataaaacag gtgtaatgcc taaggaatta atcaaaaaat tagctgatgc aaaatttata
    39301 agcagtaata tcccagaaga atatggtggt gggggagcag gatatgtttc ttacgctata
    39361 gtaatggaag aaatagctag aagatgtgct tcaacagcta cttttgttac agctggttct
    39421 tctcttgctt cattaccaat actttacaat ggtactgaag agcaaaaaca aaaatactta
    39481 aaaggtatag caacaggtga attaatagga gcatttggtt taactgagcc aggagctggt
    39541 tctgatgcag gtggacaaca aacaacagca gaattagttg gagaccacta tatattaaat
    39601 ggtagaaaaa ctttcataac taatggacca ttctgtgatg tagctatagt aatagcagtt
    39661 acagatagaa gtaaaggact tagaggaaca tcagcgttta tagtagaaag taaatgggat
    39721 ggtttctcaa caggagctca tgaagataag atgggtataa gaggaactga aacttctgac
    39781 ttaatatttg aaaacgttaa agttccaaaa gaaaacttac ttggaaaaga aggtcaagga
    39841 tttaagatag caatgggtac tctagaagtt ggtagaatag gtgttgctgc cttagctcta
    39901 ggaatagctc aaggtgcttt agatgaagct gttaaatata caaaacaaag agttcaattt
    39961 ggtaagccta tagctaaatt ccaaaatact caatttacta tagctgacat ggaaacaaaa
    40021 gtttgtgcag ctagaggatt agtttatgat gcagcacaaa agagagatgc aggaatgaga
    40081 gttgctcaag aatctgctat ggctaaatac tatgcatcag aaattgcaaa tgaagttgct
    40141 tataaagcat tacaacttca cggtggatat ggatttataa aagattatga aatcgaaaga
    40201 atgtacagag atgctagaat cgtatcaata tacgaaggaa catcagaagt tcaaaaaatg
    40261 gtaatttcat caaacgtatt aaaataataa ataatctaat gaaattggag gtatagactt
    40321 tgaaaatatt agtttgcgta aaacaagttc cagatactaa cgaagtaaga ataaataaag
    40381 aaacaggtac tcttataaga gatggagttc caagtatatt aaacccagat gatgcaaatg
    40441 cattagagga agctttaaaa attaaagatg agcatgatga tgtaactata acagttataa
    40501 caatgggacc tcctcaagca gactttatgc taagagagtg tttagctatg ggtgctgatg
    40561 atgcaatatt attaagtgat agagcatttg gaggagctga tacttgggct acatcaaata
    40621 ctattgcagc gggaatatct aaagtaggtg actatgacat aatatttgca ggaagacaag
    40681 caatagatgg agatactgca caagttggac cacaaattgc agagaaatta gacattcctc
    40741 aagttacata tgtacaagat ttcaaaatag aaggaaaaga tataatagtt caaagacaat
    40801 tagaagatgg atacgaatta ataaaagtaa gtacacctgt acttttaaca gcagtaaaag
    40861 agttaaatac acctagatac atgtctgttg ataaaatagt aaaagcatat aaacatgatg
    40921 taaaagtttg gacaattgat gatttagatg taaataaaga agaagttggt ttaaaagcat
    40981 caccaactaa agtatttaga tcatttactc ctgaaccaag aggaaaagga gaaatcttag
    41041 aaggtaaagc tgatgaaata gctagtaaaa taataatcgg tctaaaacaa aagcacatta
    41101 tataagttgg aggagtacaa actatgaatg atataaaaga tttaagttct tataaaaacg
    41161 tatggatatt tgcagaacaa agagaaggaa aaatagctcc agtagttata gaattattag
    41221 gagaaggaag aaaattagct aaagaagtag atgcagaact ttgtgcaata ttattaggaa
    41281 aagatgttga tggattagct aaagaattaa tcacttttgg agctgacaaa gtttatgttg
    41341 cagatgatgc tcttttagaa aaatatacaa ctgatgcata tacaaaagta ataaaagatg
    41401 caatagatga aataaaacca gaaataatgc ttttcggagc aactcatata ggtagagact
    41461 tagcacctag aatagcttca agagttggaa ctggattaac agctgactgt actaagttag
    41521 aaatagaccc agaagataag aaaataaaac aaactcgtcc agcatttggt ggaaacataa
    41581 tggctacaat catttgtcca aaccatagac ctcaaatgtc tacagttaga cctggtgtta
    41641 tggataaagc tgaaaaagac gaaacaagaa ctggtgaagt tatagcatta gactacaaaa
    41701 taactcaaga tgatataaga actactgttt tagaaacagt taaaactaag aaagatttag
    41761 tatctcttac agatgcaaat gttatagtat caggtggtct aggattaggt ggaccagaag
    41821 gatttgaaat gcttaagaaa ttagctgaca aattaggtgg agtagttggt tcttctcgtg
    41881 cggctgttga tgctggatgg atagaccatt ctcaccaagt aggtcaaaca ggaactactg
    41941 ttaaaccaaa cctatatata gcttgtggta tatcaggagc aatacaacat ttagcaggta
    42001 tgcaatcatc agatttcata attgctataa acaaaaaccc agcagctcca attttagaaa
    42061 tcgctgacta tggagtagtt ggagacttac atgaaatagt tccaatgctt atagaaaaat
    42121 tagatagcgt tgatgattta ttagaagcta taaaagctta atagatacaa actatataaa
    42181 tattactgat tgaataagtc ttattagtta gtaacataat tattaaccct ttgataagtt
    42241 attgctagtg tgtatttgtc agttattaaa aagtctgttt gaataaaatt ttataataca
    42301 agataatctg gataatcctt atatgtatat tgcttacaaa ttgtgagtta tattctgtaa
    42361 ggattatctt tgttttttta aataaatctt aaatttaatt aaattgtatt aaatagacaa
    42421 ataattacta aatatgtgat aaaatacaat taaaagcaaa atgaaatttt taacaaacta
    42481 taatcattaa aattatatct tagttacgtt ttaatgaaat aaactacttg aaaagacgaa
    42541 tattataagg agttgattat atgtgctgat ggtatttatt gtaagcaaac aataaatttt
    42601 gtatgtagtt caataaatta cttaatgaaa ggtgcgaata ttaatggata ataatttaat
    42661 agggcttata gaacatgtag aaaatccagc cattttatgt aaagaatcag gcgaaataat
    42721 atactgtaat catctaatag atagtatttt tagttttcta gatataaaaa agcctagaaa
    42781 tataaatgaa ttagattcaa attttgacaa aacagaaata ctgacagata gtaaaaagaa
    42841 aatagctttc agagagttaa ggatgactgc acatatatac aatatgaaag ataataataa
    42901 tgaaaataat atagtttatt tatttgagaa gtctctaata tctgataaag taattgaaga
    42961 tataatagag catatagatg aagttgttgt tgtgtttaac aaagatgggg taattgaaaa
    43021 gatgaacact gtcagtgatg agatattacc ttttaaaaga actgaggtac ttggtagaaa
    43081 tataacagac cttgtgagac aaggattagt tgaagaacca ataatattaa acatgcttaa
    43141 agtgaagaaa aagatttata gaaatatcgt ttacccagat gggaagctta ttgcatatac
    43201 ggcagttcca agatgggatt ctaagggaaa gcttacagga ggagtactaa cagggagaga
    43261 tatttcaagg gttattaagc ttgaatctca gataaaatat agtgatatat cagaagacac
    43321 agagtatata agtcaaagta agattatgga caatataaaa aaagttgtta agagagctgc
    43381 agcctcagat tcttctatat ttataaatgg agaatcaggt gtaggaaaag aaataatagc
    43441 aagaacaata tataagtata gttcaaggag agacaaacct tttatagcta taaactgtgg
    43501 agctatacca aatgaattat tagagtcaga gttttttgga tatgaagaag gttcttttac
    43561 tggagctaag aaaaaaggta aaaagggact ttttgaagag gcgaatggtg gaactatttt
    43621 cttggatgag ataggtgagt taccaatgca gatgcaaaaa aaattactta gggttataca
    43681 agaaaatact attactagaa taggtggtag taagcctata aaaatagatg ttagatatat
    43741 aagtgctact aatatttctc atgaagacct tagaaataac cttaaattta gacaagattt
    43801 gtactataga ttaagtgtta ttccagtaaa aatacctcct cttagagaaa gaaaagagga
    43861 tatagtacca ttagtaaatt atttcttaaa actttacaat gaaaagtaca atagagaagt
    43921 agaagtttcg cctaaagtta ttgagttatt agaagaatat tcttggccag gaaacataag
    43981 agaattaaaa aacatcattg aaagatttgt agtattatca gctaaaaatg taattggaga
    44041 agatgaattt aacatgctga taaatttaga tatgattgat aatgaaacag atgatttatc
    44101 accaatagtg gtaaatggaa ttatgaatct taatgatgca tataaaatag tggaccaaat
    44161 aatgataagt aaggctataa ataagtatgg ttcaataaca aaggctgctg aagttatagg
    44221 tatatatcct tctaccatcc atagaaagat aaagagtgga catattcacg tttagctgtc
    44281 agtttaaaaa gacaatataa ttaaaatatt ataagataca taatttatac aacttaaaag
    44341 agatggctta aaaataaatt taattacttt aagtcatctc ttttctttta taaatattta
    44401 aaagttatat tagtttatag agttagcaga acctaaaaca tcatctatct tgctttcaac
    44461 tacagcttgt atagcatctc taccagcacc aatgtatttt cttgggtcaa attcttttgg
    44521 attttcagct aagaattttc tgatagcagc agtcatagct agtcttaagt cagtatccat
    44581 gtttatttta caaacagcca tagaagatgc ttttcttaac atatctacag gtacaccttt
    44641 agcaccagct atatttccac caaattcatt acatgtagca acagcgtttt ggtcaacagc
    44701 agatgcacca tgaagaacta ttgggaaacc tggtaatttg ctttggattt cttctagtat
    44761 atcgaatctt aatttagctt ctcctttgaa tttgaaagca ccatgagaag ttccaatagc
    44821 tattgctaat gaatcaacac ctgttctttc aacgaactca actgcctcag ctggttgagt
    44881 atacttgtga acatcagaag taacatcatc ttctgttcca gctagaacac caagttctgc
    44941 ttcaacaaca acacctttag agtgtgcata ttcaacagct tctttagtta ttctaacatt
    45001 ttcttcaaag tcaaaatgag aaccatctat cataactgaa gagaaaccag catcaataca
    45061 agttttaata gcatccatat ttggaccatg gtctaagtga agagctacat ctacacctat
    45121 ttcatcagaa gcagccttaa ccatttcaac taatgtatga ggtccagcat atttaacagc
    45181 tgacatagaa gcttgtatca taacataaga atttttagct ttagcagctt ttaaaacacc
    45241 ttgtaattgt tctaagtcac ttatgttaaa tgcacctata gcaaatccac cttcgtaagc
    45301 ttttttaaac atttcttttg tagtaattaa tgccatttta aactcctcct attaactttt
    45361 aaaatttacc catcacttat attataacgt taaatcaaaa aaagtatata gtaaattgta
    45421 ataactataa attacaagta taatgttaaa tagaagacaa taggattaaa taaaataata
    45481 aagaatataa acaatttagg aaaactagct atataatgct aactataagg gtaggaacta
    45541 ccttattagt ttggagatac tgataacaat agttgccttg accaagaagt taccacttca
    45601 aacgttatcg aaaggaatta agtggatgat aattcactaa aaatttaaaa taaaggagat
    45661 aaactatgcc acagataaaa ataagaggaa ttaatgaaaa tgatatatgt aaaataagtg
    45721 aaaaaatgat aaatgattta gttgaagctg taaaatgtcc aagagactac tttgaaatag
    45781 aatgtataaa gtcagttgca ataagagatg gtaaaatagc agatgtatat ccttttgttg
    45841 aagtagcttg gtttgataga ggacaagaag tacaagatat agtagcaaga ataataactg
    45901 atagtataag aaataattta gatgtagaaa gtatagattt agcatttaca gtatttgaaa
    45961 aagaaaaata ttatgagaat ggagagcatt tttaatggct aaaaagcaac gtatagataa
    46021 aattctttca aatttaggtt atggaagtag aagtgaaata aagaagtatt gtaaacaagg
    46081 gtctgtagta gtaaatggaa gtgaagtttc aaatccagga actcaagtag acactgaaaa
    46141 tgatgagata ttatttaatg gagaagaagt tatatataga gaatatatat atttgatgat
    46201 gaataaacct gatggatata tatcagcaac tacagataaa tatgacccaa cagtattaga
    46261 tttaattgat ttatcatact tagcttttga accatttcct gttggaaggt tagataaaga
    46321 cacagaggga ttattagttt taactaatga tggaaagctt tctcatagag ttttatctcc
    46381 taagaagcat gtgcctaaga cttattatgc aaaaattgat ggagtagtta ctgaagaaga
    46441 tgtagaagct tttttagaag gtgtagtgct tgatgacgga tataaaacta tgccatcaca
    46501 gttaaatata ttaaaaagtg atgatgaatc agaaatagag cttacaatac atgaaggtaa
    46561 gtttcaccaa gtaaaaagaa tgtttgaaag cgtaggcaaa aaagtagtat acttaaaaag
    46621 attgtctatg ggcaatttaa aattggatga aagtttagag ttaggtgagt atagagagtt
    46681 aacagatgaa gaagtaaaat tgattgaaga aagataataa agatactata gtaaattgga
    46741 ggaatgtctg tgaagaaaaa agatgttata gaatttgaag tagataaaat ggaatttggt
    46801 ggtacatctt taagccaagt tggagataga gttatccata tgaagggtgg aataagtggt
    46861 caaaaggtga gagctggagt taaaaaagtt agaagtaaga aagctgaagt taagatgata
    46921 gaattattag agaactcacc acttgaaact gaagaaactt gcaagcactt tagagagtgt
    46981 ggaggatgta cactattgtc tgtgccatat gaaaaacaat tagaaataaa agaaaaacaa
    47041 gttatggatt tatttttaaa gcaagattta tttggatttc agtttttagg gatagaagga
    47101 agtccagaaa acaaatatta tagaaataag atggaatata cttttggaga tgaagtaaaa
    47161 aatggacctt tgacattagg tcttcataaa aaaggaaagc atatagatat acaaactgtt
    47221 gaggagtgta tgttggttga tgaagacttc tcaaagatat tagtttctag tgtagagttt
    47281 ttcaatgaaa aaaagcttcc ttattataga acaatgaatc acaaaggata tttgagacat
    47341 cttgtagtta gaaaagggat tcatactaat gagattatgg ttaatatagt aacttcttct
    47401 caagaagatt ttgatatgta tgagtttaaa gatatgcttt tagggattga tttaaaagct
    47461 gagttagtag gtgtacttca tactattaat gatggtttag cagatgcagt ccaatgtgat
    47521 gagttaagag tattgtatgg aagagattat atacaagaag aaattttagg tcttaagttt
    47581 aagatttcac cattttcgtt tttccaaacc aatactaagg gagcagaggt tctttatagt
    47641 attgctaggg attttattgg agattacaat gataaagttg tatttgactt gtatagtggt
    47701 actgggtcta ttggacaggt tatggctggt gctgctaaga aagtgtatgg tattgagata
    47761 gttgaggaag ctgttgttgc tgctaatgag aatgctaagt tgaatggact tactaattgt
    47821 gagtttattg ctggggatgt ggctaaggtt gttaaggatt taaaggacaa gcctgatttg
    47881 attattgttg accctcctag accaggcatt cataaggatg ctattaggga tatttgtgga
    47941 tttggtgcta aggagattgt ttatatttct tgtaatccta agtctttggt tgttgatttg
    48001 gttgatttta aggggtatgg ttatgagatt aagatggtta agtgtatgga tatgttccca
    48061 aatacgccac attgtgagac tgtagtgttg ctacgtcgaa aataatgcta gaaatcttga
    48121 gctttagaca gtttcataga catataatat ttagattaga gggtaataaa attaggaata
    48181 aagaattgaa aaggtgtttt gatgtgtctg tagttatata tatggagtgt gggaatacga
    48241 aataaaaaaa gttttaatta tagaaataga tattaaattt ataaatttaa tatctatttt
    48301 ttatgtgaaa atatatttaa tctaaagaat gatatttcat aaaaaaaatt aaatatattt
    48361 ttaaaatatt tacaatagag ttatttttta ttcgtataat aatagaaata ttttagcata
    48421 agatgtataa taaaggaaaa aatacagaat taaaaaacat aagatagata agtggactta
    48481 ggggagagaa attattatgc aattgacaaa aataattctt agtaactata ggtgttttgg
    48541 agaagaacct acaactattg aaattaataa tttaactgga tttataggtc ataatagcag
    48601 tggtaaaact gctttattaa gtgcacttat gaaacttttt ggagaaaagt ctagtgatag
    48661 aattattgaa agatcagatt tccatatacc tgaaagtatt gatccagata gtatttctaa
    48721 gaatgaatta tatattgaag cacaatttga gtttcctgaa ttggagagag gtaaagacag
    48781 catatctata ccagtatttt ttaaaaatat ggttgttagt gaaccaggtg ggaaacctta
    48841 tttaagaatt agacttgaag caaattggga gaaaagctca aatcctgaag gaagtattga
    48901 ttcaaatgta tactatataa catctacaac agaggagata aatcctgaag ataagcgtaa
    48961 tatcaaaaga tatgagcttg atcaaataaa gatgatttat gtacctgcca ttaggagacc
    49021 agatgaacag ttaaaaaatg tctcaggaac aataatttca agattattaa atggtataag
    49081 ttggtcagaa caaacaaagg caagaattaa aacgaaagca agtgaaacgg aggaaatttt
    49141 ctttgaagaa aaaggggttg aatcattaaa gaaatcactc gaaactcaat ggaatagtta
    49201 tcataaggat attagatatt ctaatccaaa gataaacttc aatagtactg atttagagac
    49261 aattttaaaa aaagttgaag taactttttc acctacaggg acacatcgag attatcgggt
    49321 tgaagagctt ggagatgggt tacgttcttt attttatctt tcacttgtaa atacattttt
    49381 agaaattgaa gaagaaattc taaaatctat taatgatggt aaagaagaag atatatttac
    49441 attaataccg cctgtattaa caattgttgc ggttgaagaa ccagaaaatc atatttcacc
    49501 tcatctttta ggaagggtag ttgaaaaatt aaattttatt tctacaaaag aaaattcaca
    49561 gacaatattg acatcacatt caccagcaat agtaaaaaga attgaaccaa cagacataag
    49621 gtattttagg atttgtaagg aatatgaatg tacaaaagtg aagtcaatta tattaccaaa
    49681 tgaagaaaag gaagcagaac aatttaaatt tgtaaaggaa tcagtattag catatcctga
    49741 actttatttt gcaaaacttg ttgtattggg cgaaggtgat agtgaagaga tcattattaa
    49801 gcagatgatt gaattaaaag cagaatctgt agattcatca gaaatttcaa tagtaccatt
    49861 aggtggtagg catgttaatc atttttggcg tttattaaat gatttagaaa ttccatttat
    49921 tactttgtta gatttagata gagaacgaga tggaggtggt tggggacgta taaagtatgc
    49981 aatacaacaa ttaataaata ttggtcatga taagaatgta ttactttata catgtgaagg
    50041 aatttcacaa gataatgaat ttaaagagat gcatacttgg gatgtaactg atactgaaaa
    50101 tatggctaaa tggattgaaa tgctaaaagg ttatgatgtt tatttttcag ctccgttaga
    50161 tatagatttt gcaatgttac aaagttttaa agataaatat atttcagcat taacaagtgc
    50221 ggaaggtcct aggataaaag atcatggaaa aatacaagat attgtgatca atgaagatgc
    50281 tgaagatgaa tcattgaaag ctgcttataa agatagaata gatagtgata ttaaatcaac
    50341 cttaaaacaa gaaggtggtg atggatctac ttatactgag ggagagaaag aactaatgat
    50401 atggtattca tatttctttt taggaagagg taaaccaact actcatttat ctttattttc
    50461 taataatact gatatagatt ttgaaagttt tccatactgt ctaaaggagt ttgtaaatag
    50521 tattattgaa aagatgatag atgattcagg gggtggaaga aaatgaagag gaattgggtt
    50581 agtaaagaag attggagtcc agcggctgga ttcagactag aagttgaagc gatgaataca
    50641 gttattaatg ataagaatac acttgttgta gctggtcctg gcgctggaaa aacagagtta
    50701 ttagctcaga gagcctgctt tttactagag actaatacct gtagatatcc taaaaaaatc
    50761 cttgctatta gttttaaaaa ggatgctgct gaaaatttaa aagagcgttt agaattgaga
    50821 tgtgggaaag aattagcttc aagatttgaa tcaaagacct atgatgcttt tgcaaaagaa
    50881 atcgtagata gatttagaaa tagtttagat gaagcatata gacctttaaa taattacaat
    50941 atagctgaaa atcgtgatgt tagaagagca tttgagatag caggattaaa tttcagagga
    51001 aatcaaactg aatttaataa agtatatgga aataaactat cgataaataa attgccttta
    51061 catacagatt ttgtagataa gatttttata gatgcttgga atgtactact taaaggcaac
    51121 aaagatacta attttgtaag ttcacttact tttggtatga tatcacgttt agccgaatat
    51181 ttgataagaa ccaataggta tattaagaaa gcaattgaaa tgacttatag tcatgtgttt
    51241 ttagatgagt ttcaagatac taaatctatt caatatgatc ttgttaaagc ttgttttttt
    51301 aaaacagaaa caataattac tgctgtaggg gatggcaaac aacgaattat gttatgggct
    51361 ggtgctagaa agtcaatatt tgaagatttt caaaatgatt ttttaagtca aaaaagaaca
    51421 ttaattatga atcatcgttc agcgccaaga cttgtagaga ttcaaaaagc aatgtataac
    51481 agtttgaatg aagaggcaat tgatttaaaa actaatgaaa agtggaatta tgaagatgga
    51541 gaagtgtatt taagactttt tgaggattat ataaaagaag ctgatatact tagtgaggaa
    51601 atagtcgaat tggtggaaac aggtatagaa attaatgaaa tatgtatatt agtaaaacag
    51661 agcgtagata tttattcaaa agagattata aataaacttt ctgaacgtaa tattaaggcg
    51721 cgtaatgaag caatgtatca ggagatatta aaagaagata taataaagac actggtttcg
    51781 ctttttaggt tgtcgttaag tgatagaaat cccgatgatt gggattatat ttacgatatt
    51841 ctaggtgaat tatatggaat agacgaaggg tataacccta aaatattaaa tgatttcatt
    51901 accaaagtag aattaatgat taatgatctc aaggtaaatt taaatattac tgatgaaaaa
    51961 caattttcag atttagttga ttctaaggtt gaatatattt catatgaaaa atttgcatca
    52021 aagtttcaaa aatataaatc taaagattat tttgatgatt tggtagataa atttaaaaag
    52081 ctggtatgga ttgaatataa tgaaactaaa gattggatta aagcgattga taactttgaa
    52141 ggtaaaaatt caattccaat aatgacaatt cataaaagta aaggacttga atatgatact
    52201 atcttttttg ttgggttaga agattcagca ttttggaatt ttaaaaatca accagatgaa
    52261 gatagatgtg cattttttgt tgcattatca agagctaaaa gaagaattga ttttacattt
    52321 agcttagata gaccagcagg attttcgaat tcacagaagc attattgtat taatgaattc
    52381 tacgaattgt ttgataatac tgagattgta aaaaagatag agtattgatt aagatgataa
    52441 aaactttagt atattatatt ttaagatatt agttatataa gtagacattg aatttatgta
    52501 tttgatgtct attttttata taaaaatata ttaaagaaag gatgaatttg catgaagaaa
    52561 aaaacaaaaa tatctaaaaa gattgtaagt tttattatgg tttttataac tatagttact
    52621 actatactta catcatcagt ttcagcttat gctagcgagt tggatatgag tgaacagaca
    52681 ggctttaatt atttaggtat tagtccaatt acaggaaaaa aattaatcat aacatttatc
    52741 gtatgaagat ggataataaa attgtatttt gtgtagagcc aggaattaaa acttcaagtg
    52801 gaggaggata tatatcggag gagttaggag ataaatttat atctacaaca cttccaaatt
    52861 atcataaaag aaaagctgaa atacttgaga aggtaaatag acataatata ttaccttcat
    52921 ggaataatga aaaagttgca gttaaaagtg gagaaacaat tgagttagaa gataagaatg
    52981 gtattattag agaaatgcaa ttagaatcaa ataatactgg aacagatata ttacttgaag
    53041 aaaatacttt gaaaattaca gcaaataaaa attctaattc aggagttatt agttatataa
    53101 agattcctaa aaatgaggtt ggaatatcaa tagtttatcg taagcataac tatcaaagct
    53161 tatcagaatt tcatatggaa agttcgatga gtgcaaattt aaatataaat gtaatcaagt
    53221 taggaattgt taaagtaaaa aagattgatg aaggcacagg aaaggaatta gcaaatgcaa
    53281 aacttagatt tgagtatgat ggtgatagta aagaaattat aacgggttct aatgaaattg
    53341 ctagtataga agatattatt ggttgattaa aaagtgaagt atacttttgt atctatgaaa
    53401 aagactataa gcaatatata aaattagata tacctattga tgaagcaaaa ataaaaaata
    53461 gatttgaaat aaggttaaaa aatgaaagag catatcatgc agcagttgat ttgttagcaa
    53521 atagagatga agaaaagaca gcattttcaa ttattaatcg ttatatacgt tttgttgata
    53581 aagatgatga aaaaattaga agtgaatgga aaactaatga tcagtggagt tattttattg
    53641 gtgaaggtag agcgaagtta aaactaacaa caaatccaga accatataat attcaaaaaa
    53701 ctttaaattg gttatcaaga caagttgcac caacgttaaa aacaattaaa aggttagata
    53761 gtttgaacaa ctcaacatta attgagggct taataaggta tgcaagacta acagataaac
    53821 ataaaaaaat aattgaacaa aattcagtaa atgttgaaga cattatttat gatgaataaa
    53881 aaaatgtaat tagtattgca gattttaata taaaagaagg gagatatacg aatgaatttt
    53941 ggtcaaaatt tatataatta gtttttatca aatgcacaat cattggtatt aatggctata
    54001 gctataattg gtgtatattt aggattttag agagagtttt caaaacttat aggattttta
    54061 gtagttgcat taattgcagt agggcttgtg tttaatacag caggagttaa agatatatta
    54121 ttggagctat ttaataaaat aataggtgtg taaggattaa aagagaatag aaaattatga
    54181 gtatatgatg aagggttcta ataagtttta ttaaaatata tattgaaaga caagtagagc
    54241 tatttcgagt tattacatgt aatgctaata tatataactg cattttggaa attaaataca
    54301 taattagaaa tagcaaattt tataggtgac ttattaatat gtttacttat tgtatactat
    54361 ttgatatatt taatatgagg tgattcttga aaatggacat agtgaaagtt tttgctaaca
    54421 atgtgagaaa atatagaaat aaaaaaggtc tatcacaaga agcttttgct gaaaaagctg
    54481 gattgcatag aacttatatt tgtgctattg aaagaaaaaa gagaagtatt gctttagata
    54541 atgtgcagaa aattgctgat gcgcttgaga ttgagactta cttactattt atagaaggtg
    54601 aggagaaaga atgtctatga aaaaattacc aatagaaaag cttatagaaa atttaggttt
    54661 ttcagggtca aagaatcttg tgaatataga tatgcttaca aaattagata tatctaaaca
    54721 tgatgtaaaa actttaaaag ttataaatcc ttatgcaatt tatttagtaa atagtaagcc
    54781 atttatatta tttatagagt cttcttttga agaaaaaaaa ttacaacaaa ttagtaagct
    54841 tatatggaat gctcaaatac caattgcttt tatatgcgat tctaattctg ttaaaatatt
    54901 taatggaaaa gctttggatt taaagtcata tttaattgag gaaatatata atcaatctat
    54961 tgaggatttt tcggaagaat ctgagttttc ttatttgaaa atatctgatc cattattttg
    55021 ggatcaatac actaaacaat ataccaaaac gcatttaaat gattatttgc tagataatat
    55081 tacttcattg acaaataaat taaagaaaaa atataaggtg aaatttgcaa cgaagcttgt
    55141 tctaagatta atatttatta gatatttaat cgatagaggt gtcgatatag cttataaaaa
    55201 ttttaatcat gatattaaag cttcacaaaa agaactgcta aagattacta aaaacaaagt
    55261 tgaattatat gaactgttta aatacttaaa agaaaagttt aatggtaatt tatttgagtt
    55321 aaatgacgaa attaataata cttgtttaac agatgaagtg tttattttac tatctgattt
    55381 tttatcaggt aaaataagta ttgacaatgg acaaatgtct ttattttcaa tgtatgactt
    55441 taatatcata ccagttgaac taattagtaa tatatacgaa attcttttag gaaaagaaat
    55501 tcgtaataaa gataacgcat tctatactcc gaattactta gcagaatata ttttagataa
    55561 aacaacactt gaatttctga aaaataatag gcaatacaaa attctagatc cttcttgtgg
    55621 atcaggagta tttttagtaa atagttttag acgtattatt gatatgaatt tgggtgataa
    55681 acttttttgt gaagatgata aacttttaaa agaactttta ttatctaata tttatggaat
    55741 tgatatcaat gaagatgcta tcgatgttac tattttctcg ttatatctaa ctattttaga
    55801 ttacaaagac cctaagatat tatcagaatt taaactgcct aatttaaaag ggtgtaattt
    55861 aatagcgagt gatttttttg atgataataa attggagagt ttaaagaaaa ttaactttga
    55921 ttttatcatt ggaaatccgc cttggggaag tgtctcagat ggattacatt tagattattg
    55981 caataaaaat ggctataatg atatgcaaca aaacaaagaa atcagtagaa gttttatttt
    56041 tagagcaaaa gattttagct ctagaaatac agtatgttct tttgtagtgc attctaaaat
    56101 actatatact caaaaaaagc catcaaaaaa attccgtgaa tttttgctta aaaaaagtca
    56161 aatatttagt gtagttgaaa tgtcatctgt aagaaaatta gtgtttaaaa atgcagacgc
    56221 tcctgcagca gttatatcat ttaagtataa cgaaagtgaa gaaaatttaa ataatagaat
    56281 catctataca tctttaaaac caaatgtatt ttttaaatta tttaacatta ttgtaattga
    56341 aaaatatgat gttaaatata tttcacaaaa actattattg gagaatgatt gggcttggaa
    56401 aactattgtg tatggattca gtaaagatat agatataatt atgaatatca aaaaaaaata
    56461 tcaaactgta aatgaaatta ttttgaaaaa cagttttgtt catggaacag ggatacaaat
    56521 caatggtaat gaaagccatg atgcgacaca tttaaaagga aagtggtatg ttgattcaaa
    56581 gaaaggaata gattcattct atgttgatat aaataaaggg aaagaactta ctcaagataa
    56641 aatgagaaga cctaaggcta atcagcaaga aatatttatt cctccatatg tattattaaa
    56701 aaagggagtt gacacgaaaa catatagata tagagcagca ttttcaaatg atgcatttgt
    56761 atattcagat gcagttacag gaatatgtgg aaaaaaagat aatttaacta cactttattg
    56821 cttgactggt atgcttaact cttcttttta ctcatactta aatataatgc taggtacatc
    56881 aattggaata gaaagagaac aaggattttc aacggaaatt tttacgtatc cagcaataga
    56941 aagtgatgaa attgctaatc tggtagtaaa aatacaagaa gcgactaaat tagaaaaaac
    57001 aactatgttc ttgaatgaaa aaaatagttg taagtatatc aaacaattag ataagttaat
    57061 tttgaagtct tttaatttaa atgatgataa atttattgac tatgcaataa atattcaaat
    57121 tcctgagctt acaaattcta agtcaactaa catatataga aaaataacta aggaagattt
    57181 aattaattat agtgaatgtt tcaaagaaca gttttcatcg atatatcgta gggttgggaa
    57241 aagtatttca atttcggtat atccaaaaat attaaatcgt tttacagtat ttgaactaga
    57301 agtaacagat gaaaaaacag atagagagat tatggttaaa gcagaagctg ataataatat
    57361 ggagttgttt acgaaaataa ttagatatga ttataatgat gtttttcatc aaattagaga
    57421 tattattcat tttggagaaa attcatttta tatcataaag cctaattgct ataaatattg
    57481 gcatcctgct atcgcagaaa tggatcttgc tgatgttttg gatcagattt tatctgatac
    57541 agggggtgaa gaataatggg aggatttaaa aattcttcac taaactttta tttaaagcaa
    57601 gggctttatg aaataattat agatggatta atagactgtt gtttacttat gagcaaatca
    57661 tgtattgaac aatctagaaa aatattaaat cacgaagaaa agataagaac gcatttagtt
    57721 gaaaattatt tagaaaatga tattgaaaga agaaaaacat ctttatctaa acaacatcta
    57781 agatttgaag tagaagcaca agaaaattat gacaacaaaa atgaatctta tgagggtagg
    57841 gttgatataa aagttatatc taaagacact ttagcggata gaagggctta ttatatcatt
    57901 gaatgtaaaa ggatagatgg taaggaaact ttaaataaaa aatatataac cgaaggtgta
    57961 caacgattta ttactgagaa atattcttcg cattatggca aaaatataat gcttggattt
    58021 atagtaaaag atataaatat ccagagcaat atacaaaaaa ttaattcact gaatcagaac
    58081 atattatata catatataga tacagatatg ttgacagtta gaagtgattc tgaaaataat
    58141 tatgctgttt gtgaaagtaa atataaagta aaatctaaac tactattgtt aaatcatatt
    58201 ttttataact tttcgagtat aataagataa tcttatgaat ataaaatatt actatgttaa
    58261 aattatagtt tggttttgat aatattataa aaataagttt aagaataaaa tataaaggaa
    58321 aaaaggggcg tagcactatt ttttagtgtg acagcccctt taattttaaa atcggtaagg
    58381 aggagtgtat ttgaaaaaaa ttaagtcata tacagggatt ttgaatgtgg agaaggttat
    58441 atatgcaata aatgattttc agcttccatt tccagttact tttacgcaga tgacatggtt
    58501 tgtattaaca ctttttataa ttatattatt tggtaagtta cctccattat ttatgataga
    58561 aggagcattt ttaaagtatc ttggcatacc aatttttata acttagttta tgtctcaaaa
    58621 gacttttgat ggaaagaaac catatggatt tttaaagtca ataatactat attcattaag
    58681 acctaaaata acatacgcag gaaaaaacat taaatttaaa aataaaatta ttgatgaaaa
    58741 tataactata gtaaggagtg aattatatgt tcccgataaa atatatagag aacaatcttg
    58801 tatttaataa ggaaggagaa tgttttgcat attatgaatt aataccatat aattattcat
    58861 tcttataagc tgaacaaaaa tttattgtac atgataattt taggcaatta atatcacaaa
    58921 gtagaaatgg taaaattcat gcacttcaaa tagccactga aagttctata agagttacac
    58981 aagaaaggtt aaagaaaaat attacaggaa aattaaaaga aattgcttat gaaaaaatag
    59041 acgagcaaac agaggcactt gtttctatga ttggcgataa tcaaattgat tatcgttttt
    59101 ttattgggtt taagctttta gttacagaga aagaaatgaa tataaagagt ataaaaaagt
    59161 caatattagc taatctatca gattttatat atgatgttaa taataaattg atggatgact
    59221 ttgtcagtat aaataatgat gaaattatga gatttttaaa aatggaaaag ttattagaaa
    59281 ataaaatctc aagaagattt aaagttagaa ggttagataa aaatgatttt ggatatttaa
    59341 ttgaacataa ttatggaaag aaaggcacag tttttgaaga ttatcaatac catttaccta
    59401 caaagaaact taaaagagaa acattagtaa agaaatacaa tcttataaag ccaactagat
    59461 gtcttataga agagaagcaa agatacttaa aaattataca tgaggattca gaaagttttg
    59521 tagcttattt tactattgaa attattattg gagaaatgaa ttttccatct agtgagatat
    59581 tctattatca gcaacaacag tttgcatttc ctattgatac tagtatgaat gtggaaattg
    59641 taacaaataa aaaggcttta actacagtta gaaataagaa aaaagaatta aaagatttag
    59701 acaatcatgc ttggcagtca gggaatgaaa cagtaacaaa tgtagtagaa gcattagagg
    59761 ctgtaaatga gcttgtaaat aatttaaatc aaacaaaaga atcaatgtat aagttaagct
    59821 atgtaattag ggtatcagca gatagcattg atgaattaaa acgccgttgt gatgaagtta
    59881 aagattttta tgacgattta aatataaaat tagtacgcct aatgggagat atgataggat
    59941 ttcacaatga atttatacct tcaagcaaaa ggtatataaa tgattatatt caatatgtaa
    60001 ctagtgattt tctagcagga ttagggtttg gagcaactca atagcttgga gagaacgaag
    60061 gaatatatat tggatatagt ttagatacag gaagaaatgt ctatcttcaa ccatctcttg
    60121 caagtcaagg agtaaaagaa tctgtaacta atgcgttggt agcagcattc tttggatttt
    60181 taggaggtgg gaaatcattt gctaataact tacttgttta ctattcagta ttgtttggag
    60241 ggcaagctgt tttggtggat ccaaaagctg aacgtggcaa atggaaagaa aatttaccag
    60301 atatatatca tgaagtaaat attgttaatt taacaagtga tatagaaaat aagggaatgc
    60361 tagatcctta tgtaattatg aaagaagtaa aagatagtgg aagtctagct attgatatat
    60421 taacttttct tacaggaata agtagtcatg atggagagca gtttcctata cttagaaaat
    60481 caatcataaa tgttactcaa gacaaatgca gaggactttt gaaggtaata gatgaattaa
    60541 ggaaagataa ttctcaaata tcaaataata ttgcagatca tattgaaagt tttacagatt
    60601 atgattttgc acaattactt ttctcagatg gaaatattaa aggctcaatt aatctagaaa
    60661 aacaaatgaa tataatacaa gttgcagatc ttgttttacc gaataaagat actttatttg
    60721 aagaatatac aacaatggaa agtctttcag tagctatgtt gatagtaatt agtacttttg
    60781 cattagattt tatccataca gatagaagta cttttaaaat agtagattta gatgaagctt
    60841 ggacatttct taatgtagca caaggaaaaa ctttatctaa taaattagtt agagcaggat
    60901 gtgctatgaa tgcaggagtg tattttgtaa ctcaaaatgc aggtgatgta tcagatgaaa
    60961 atttaaaaaa caatattgga ttaaaatttg cattcagaag cacagatatc aatgaaatta
    61021 agagaatact tgaatttttt ggagttgata aggaagatga gaataatcaa aaaaggttaa
    61081 gagagttaga gaatggacag tgtttaatac aagatttata tggacgagtt ggggtaatac
    61141 aaatacatct agtttttcaa gaactcctta ctgcatttga tacaagacca cctataagaa
    61201 aagaggtgga ttaatgaaat cgaaagtatt tagaaattta agctggataa ctattttaat
    61261 agtagtactt ttactatttt ttatttatat aaatttatag atttagagaa acaaatagat
    61321 acattagata agaaaagaaa aaaactcata gatatgagat tagaagatat aattgataaa
    61381 gaatcatatg aagaaaagta tgatgattta acagttgaaa taaagaaact tagtaaagag
    61441 aaaaaaactc ttaaagcatc attaataaat gaaaagagta taaaagcaag acttagagaa
    61501 tttagaaaga tacttgaaag aaatgaattg ttagaaaaat ttgatagata tgtatttgca
    61561 agtatagtag ataaggttat agttggagtt attaatgaag atggtatagt tgatccttat
    61621 aaaataactt ttgtttataa aactagcttt gatgataaac aagatggaca taaatttata
    61681 aataagagtc cgttagaaac gtattcaaaa gataacaacg ataataaaaa gaagtgttca
    61741 tatactaata atgagacatt gcgagactgt agttaaactt attagagaat aacaaggttt
    61801 cagactttta tattgtgtct taaaagtaga tttgccacct atttgccacc ataattattt
    61861 ttgggtggca aatttattct acaatgattt caaaaatatt taccgtctgg tttctcatgt
    61921 tgttagttac atgtaaatat gtatccatag ttgttgaagt tttagcatgt ccgagtatat
    61981 gctggatatc ttttatatta gtaccatttt ctaataacat agtatcaggg tttttaaaat
    62041 aaagtgtgta ttcttctaaa gtagtgataa ttaaaatatc aaatatcact atacaaagga
    62101 aagtgcacgc tttttatgtt taacaaaaac gaaatattaa aaaacttatt gaagaatatg
    62161 atgtcaaaac aactacagat attcaagata tgctaaaaga tttatttaca aatacaattc
    62221 atcaaatatt tacattgtcg aattttagcg gtttaaacat aatatattga ctgatataat
    62281 aaaatcatag aatattttag ggggaaatag attatgttta agaaaaagtt aatagctgtt
    62341 gcaatgagta taactatgat tagtgtaggg agcttttcgt atgctcattc aggaagaact
    62401 gattcatcag gaggtcatcg tgataataaa aataaatctg gattaggaag ttatcactat
    62461 cattgtggtg gttatccagc tcatttacat aataatggtg gttgtcctta tactggagga
    62521 ggaagcagtt ctggaacaac aacttcggtt aataatgaag aaaagcaaaa gaggtctgtt
    62581 ggagaaaaag gatataatca agggtatgaa gatgggtata aaggaaatta tagttcatca
    62641 aattatagtg gagattatag tgatacatat gaatcaaagt actcagaagg atatgaaaaa
    62701 ggtaaggcta aattagaaga ggaagaaaag gtggctaaag agactggata taatttaggg
    62761 cttacaggtg ctaaatctaa taatacatat gaaaaagaag ttttaaaaaa tgcttatgat
    62821 accggatatt caactggata caatgaatat aagactaaaa agatagaaga atataaagct
    62881 aaagggatag aggatagcaa taaagataag gaaaaaatga catttgaaga aaacatagat
    62941 tctgaattta tagatgctta taataatgct tatgacgaaa tacaagaaca attaaaaaat
    63001 gattacacta ctcaaggatt tgagagtgct atcaaaggag aaagatttga cacatcaact
    63061 ataggtaatg ttaaatatgc taattggttt aaagaaggat atgataatgg taaggttaag
    63121 ttacctaaag caaaagaaag tgtatataat caaggttaca atgaagaaga ttttagtata
    63181 ccagatgaaa tgaagtctat tgaaactaag ttaaaaggtg tatatgatga aggtttagaa
    63241 aaaagagaag aagagaaaag tagaaatgct acttatgggg ttggagctgg aacagcagct
    63301 gtagttgctg gagtagtata taagaagaaa aaacgtaaaa agatatagat gctagatata
    63361 ccaatgatga caagtgtata acaaatataa ttttaagtat aaatatttaa aatatagaag
    63421 ggaaggttat atctatggga tttaacttta ggaaaagcat aaatctagga ggaggactca
    63481 aattaaattt aggtaagaag agtgtaggta taagtgctgg tgttaaaggt gctagagtgt
    63541 cagttaattc aaaaggaaga aaatcagcta cattgagtat acctggaact ggaatatcat
    63601 atacaaaaac tagtacaaag aaacgtaaac ctaaataaat atttgatata ctaagaaata
    63661 gactgttaca aatagtctat tttttagtat atagatttaa aaagtgacaa aattttgaaa
    63721 tataaactaa tttcataaag gaaaatatta ttttatgtag aattataata tttaagtaat
    63781 attataaaat ttataggagg atttcattat gaaattaagc aaaatactat tggcaatagg
    63841 gatgtctgtt tcattattga ttgctagttg tccaacatca aacgctctta gttctattaa
    63901 ttcaataaaa ggtacaaata agtatgaaac agcaggttta atagcagata aacaaaatta
    63961 tgatattgca atacttatta attctgaaaa tggattatct gatggattgt cagcaagtgg
    64021 attgtcagga gctaaaaatg ccccaatatt gttaactaag aaagatacaa tcccttcaga
    64081 aacattaaaa agattagaaa aggtaaaaga agtatatcta attggaggaa aaaattcgat
    64141 aggagcatca gttcagaaaa tattaagtga taaaaaaata agcataaata gaataagtgg
    64201 aactgataga atagatacaa gtcataaagt tgcaaaagaa ataggaagag taagtacggt
    64261 taaaaaagta atattaacta atgcttttaa aggcgaacca gatgctatga gtgttgcttc
    64321 tatagcagtt agagataaat ctccaatagt attaactgat ggaaatacta caagttttgc
    64381 tacagatgga ttagaaactt atgcaattgg tggaaaagtc agtatgagtg ataagttaat
    64441 aaatgaaact aaagcaacaa gaataggtgg agtagataga tacgatacaa ataaacaaat
    64501 aataaataaa ttttataatg gctcaaaaga attttacata gcaagtggga ctgatttagt
    64561 ttattcttta gttggttcta caattgcaca aaaaacacct atagtgttag ttggaaatgg
    64621 aagtaataag agtatattaa aaaatgcaag taaaataact gctattggaa atattgatga
    64681 tgttgttata aaacaatgtt taaatataac taataatgtt ggggattcaa atacaggtat
    64741 tgtaaaagat actaattcaa ataatacgaa caaaccaagt aatgagccta gctctaataa
    64801 tcctggatta actgataaaa gtacagtata tgtaactcct aatggaaaat catatcatct
    64861 aacaaaaaat tgttctacac taaaaagaag taaaacaata aataaagtaa cattaaaaca
    64921 agctaagtca caaggtaaaa tagatccttg taatgtttgt gtaaaataat gtattagcca
    64981 aatatatatt aaaaaagaca attaattaag attgtctttt ttattgaaga aatata
//
LOCUS       DAEHWM010000008        64376 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.008, whole genome shotgun sequence.
ACCESSION   DAEHWM010000008 DAEHWM010000000
VERSION     DAEHWM010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 64376)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 64376)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..64376
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.008"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            382..1578
                     /locus_tag="KNP36_000554"
     CDS             382..1578
                     /locus_tag="KNP36_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HBF0872445.1"
                     /translation="MKILVLNCGSSSLKYQLIDMNNEEVLCIGLVERIGIEGSILKHE
                     KAGRDDKYVVEQPMKDHKDAIALVLEAVAHPEFGAVKEMKEIDAVGHRVVHAGEKFAT
                     SVVITPEVEEALKECIDLAPLHNPANIMGIDACKAILPDVPMVGVFDTAFHQTMPKSS
                     YLYGLPHELYTKYGVRRYGFHGTSHNYVSQRAAEILGKDIKDLKIVTCHLGNGASIAA
                     VDGGKCVDTSMGFTPLEGLIMGTRCGDIDPAILPFLMRKEGLDADGLDKLMNKESGVY
                     GMTGISSDFRDIEDAAKNGDERAQATLEAYVKKVQKYIGAYAAEMNGLDVVVFTAGVG
                     ENGKAIRADIASNMEFLGMKLDKEANDVRGKETVISTADSKVKMLLIPTNEELMIARD
                     TLRLVK"
     gene            1671..2195
                     /locus_tag="KNP36_000555"
     CDS             1671..2195
                     /locus_tag="KNP36_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HBF0872446.1"
                     /translation="MKVSIEKINRKETDKIDLNFCEKIDTISYCDEIYKLVSPVNLKG
                     KVSKTNKGLYLDIDVNFTIVDNCSRCLKEVEIPLEYSIQGFLVKEEDYDEDEFEEFDP
                     FIFDGEEIDLIDIIEQTLDFNVPHKVLCSENCKGLCQVCGANLNEEECSCSEITNDEE
                     YIDPRFAKLKDLFN"
     gene            2220..2396
                     /gene="rpmF"
                     /locus_tag="KNP36_000556"
     CDS             2220..2396
                     /gene="rpmF"
                     /locus_tag="KNP36_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HBF0872447.1"
                     /translation="MAVPKRKTSKSNTKMRRAANSKMEATGFVSCPQCHEPKLPHRVC
                     PDCGYYKGKEVVSK"
     gene            2603..3160
                     /gene="fapR"
                     /locus_tag="KNP36_000557"
     CDS             2603..3160
                     /gene="fapR"
                     /locus_tag="KNP36_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription factor FapR"
                     /protein_id="HBF0872448.1"
                     /translation="MKKKSKAQRQKELIDMLKTDPFYTDEELSSLFDVSIQTIRLDRM
                     SLNIPELRERVKSIAETQSSKVKTLGVKEITGEIIDLSVGRLGISMLEVTQDMIYSKT
                     NTLKDTYIFSLADSLAMAIIDAPKVIMRVANVKSFKLIEQQDRLIAKAEVYRNIDKKH
                     YVKVVINNKAQEQIFRGKFIFEELD"
     gene            3171..4193
                     /gene="plsX"
                     /locus_tag="KNP36_000558"
     CDS             3171..4193
                     /gene="plsX"
                     /locus_tag="KNP36_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HBF0872449.1"
                     /translation="MKIVIDGMGGDNAPKSNVEGAVNAIKEYQVDLIITGDKDLLEKE
                     FSNYEFDRNKLEIVHTTEIIENEDKPVKAIRSKKDSSMVVALNLVKEGKADAIISAGN
                     TGALLAGGLFVVGRIKGIDRPCLCSAIPNVKRGMTLIADCGANADCKPKNLVEFAAMS
                     NIYSRKVLGLENPKVALANVGLEEGKGNDLVKRSYEEIKKLDLNFIGNVEAREVINAY
                     TDIIICDGFTGNILLKSAEGVALSVMSLIKETFMASTKSKIGALLIKDDLRKLKSFID
                     YSEYGGAPLLGLNGGVIKAHGSSDAKAIKNAINQGIKFSKGKVVEDINQFISKYNEEN
                     KNNEDE"
     gene            4219..5205
                     /locus_tag="KNP36_000559"
     CDS             4219..5205
                     /locus_tag="KNP36_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HBF0872450.1"
                     /translation="MNTKAGILGVGSYLPEQSYDNFHFEKIMDTSDEWISTRTGIKER
                     RFAKESEATSDLASKAALKAIECAKLNVEDIELIILATITPDMSLPSTACIVQDAIGA
                     VNATAFDISAACSGFVYGVTIAKQFVETGCYKNVLVIGAETCSKFLNYDDRTTAVLFG
                     DGAGAAVIGPVNEGGILSTHMGSDGKGKDCLKVPAGGSRLKASKETVEANLHTIEMAG
                     SDVFKFAVRKMAETSLRALEKANLNTTDIDYLVPHQANIRIIQASSKRLELDMKKVYV
                     NIDKYGNMSAASIPVALDEAYREGKIKKGDNVVLVGFGGGLTWGASVVKWTL"
     gene            5314..6243
                     /gene="fabK"
                     /locus_tag="KNP36_000560"
     CDS             5314..6243
                     /gene="fabK"
                     /locus_tag="KNP36_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HBF0872451.1"
                     /translation="MNKICKILNIKYPVIQGGMAWVATASLASAVSNAGGLGIIAAGN
                     APKEAIKKEIVECKKLTDKPFGVNVMLMSPFVDDIIDLIIEEKVQVITTGAGNPAKYM
                     DRLKEAGTKVIPVVPTIALAQRMEKLGATAVIAEGTEGGGHIGELTTMVLVPQVADAV
                     NIPVIAAGGIVDGRGIAASFALGASAVQVGTRFICSEECSVHSNYKNLVLKAKDRDAI
                     VTGRSTGHPVRTLKNKLSKEFLKMEQNGATPEELDKKGTGALRFATVDGDIEKGSFMA
                     GQSAAMVKEITPCKEIIEAMVNQAREIMPAIEL"
     gene            6259..7209
                     /gene="fabD"
                     /locus_tag="KNP36_000561"
     CDS             6259..7209
                     /gene="fabD"
                     /locus_tag="KNP36_000561"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HBF0872452.1"
                     /translation="MGKVALVFPGQGAQYVGMAKDLYENNAVAKSVIDEASDALNMDL
                     KNLMFNGNEEELSKTENTQPAMVTHSVAVLKAVQAQIDLKYNACLGLSLGEYSALVAA
                     DAIDFKDAVCLVKKRGKFMQETVPAGVGAMAAVLGLDRNVLENVVKDIQGGIVEVANY
                     NSPGQIVISGENEKIEEAMVKCKEAGAKRAVKLNVSGPFHSSMLKEAGVKLASELEKV
                     NITKPKVDVVANVNADYYKNEGKDLLIKQVSSSVLWEDSIERLLNDGYDTFIEMGPGK
                     TLKAFIKKIASNKKANVNIYNIDGIDSLNEFVQNYRNGEI"
     gene            7209..7958
                     /gene="fabG"
                     /locus_tag="KNP36_000562"
     CDS             7209..7958
                     /gene="fabG"
                     /locus_tag="KNP36_000562"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HBF0872453.1"
                     /translation="MINLTGQVAVVTGGSRGIGKEIAKKLASFGADVVINYTSKEDEA
                     LKTKNEIESMGVKCTSIKCDVSKFDEVNQMIDSVVSEFGKIDILVNNAGITKDGLLMR
                     MKEEDFDRVIDINLKGVFNCTKAVTKPMMKKKYGRIINMTSVVGIMGNAGQTNYCASK
                     AGVIGFTKASARELASRNININAVAPGFIETDMTKVLSDDVKESTLANIPKKSYGKPE
                     DVANAVAFLVSDMSSYITGQVINVDGGMVMQ"
     gene            8012..8236
                     /gene="acpP"
                     /locus_tag="KNP36_000563"
     CDS             8012..8236
                     /gene="acpP"
                     /locus_tag="KNP36_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HBF0872454.1"
                     /translation="MFNKVVEIIIEQLGVEDKEITMETSLMKDLEADSLDAVEIIMAL
                     EDEFGIEIPDTEAENFKSIGDIVKYIEANK"
     gene            8265..9503
                     /gene="fabF"
                     /locus_tag="KNP36_000564"
     CDS             8265..9503
                     /gene="fabF"
                     /locus_tag="KNP36_000564"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HBF0872455.1"
                     /translation="MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDAST
                     YQTQIAGEVKNFHPEEYISKKELKRLDKFAQFAIVSAKLAVEDANLDLDKVDRERFGV
                     IIGSGIGGVEAIETQHKILLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVC
                     TACASGTHSIGDAFKVIQRGDADLMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTA
                     SRPFDKDRDGFVMGEGAGIVILEDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENG
                     EGAARSMNMALKDGNVPLEEVDYINAHGTSTYYNDLYETMAIKTVFGEKAYDLCVSST
                     KSMTGHLLGASGAIEAVVCAMSIEDSFVPPTINIQEVGEDLDLDYVPNQGKEKNIRYA
                     LSNSLGFGGHNATIVLKKYV"
     gene            9729..11447
                     /locus_tag="KNP36_000565"
     CDS             9729..11447
                     /locus_tag="KNP36_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0872456.1"
                     /translation="MNFRLPKKRLPKKIIFICIILISIILFIKYDQNGLKEREIINKG
                     KYMSESLVADKEYDEAKKVVKTSFESIPEKKYNKVYNEVWDMLKTISYVPDGTKIVID
                     SLEKMRESDVKLSDECRFNIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKA
                     RLDVDLASIFLKIGGYETGEKLIKDSFKIDIDEGEKNGMVRLYAIINLAEIYVEEGEY
                     DKAIEISSRIKDYKKFVNTDNYNDFDIMASIMQSNAYVGKNNIQKAKTFLEKADYLIK
                     SDRTVYILDKDMYYYMAMGNLEYKSENYNSAIDNYKKSLEISTKRKLTQEKIKNLNKI
                     LNIYEKQGNIESLNEYQKMLINEYKENKSIRDSETSFYIIDKVSNESKLFEKTKKEIK
                     YYKILFTVILIAILGSTFLYNRLKYFKAQNLHDGLTNVYNRKSFDIMYEKYREKDDNF
                     ALVMIDIDNFKLINDNYGHKFGDTVIKGITNTICVMLEQDDKVFRYGGEEFSVLIRNK
                     SGDEVADIIDSIRVAIANKKWNDDVTVTISAGVAHVSDSKDVLEEADKNLYKAKQLGR
                     NKVVYK"
     gene            11478..13478
                     /locus_tag="KNP36_000566"
     CDS             11478..13478
                     /locus_tag="KNP36_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872457.1"
                     /translation="MKQSIAIVTDKITKLSSFLEENIRLVLGNYIDINHYYLEVLKEN
                     DKIQGDFVLVMNDDRLNSMRKHLVQDSKIIVIRRTLKENEIYGLFSIPNGTEVLVVND
                     TKETTLETISLFYKIGVKNLKFTPYIEGKIYKNIDIAITPGVKGKVPSYINKVIDLGN
                     RYIDISTFIEIINGLRIDVKEIRKNLMAYSESLISLDNGVKDNYRQLFLKIEEQDVIL
                     NLSKDGIIFTSADGIINTFNKEALKILGINENPQGKNIEDIISEDLNILLEDKEIIDE
                     VVFTNKKYINVNKKSIFSMGNKAGIYYNLQEITYIKKLEQNLTNKLREQGQIARYTFK
                     DIKTKNKNMVKCVELAKKISKSDLSVLIIGESGTGKELLSQSIHNASNRSNQPFIAVN
                     CAAVPDSLLESQLFGYEKGSFTGALREGKKGLFELANNGTIFLDEIGDMPPLLQTKLL
                     RVLQEKQVMPIGSHNVINIDVRVIAATNKNLLKMIREGKFREDLYYRLNVLPIDVPSL
                     RNRKEDIITLMNFFLKNNIRLSPEVITILEKYNWPGNIRELQNVASYVSLMCDSMVFR
                     DDLPPYIRVECANNYEDGFGYTRKEFEEILRILYERRESSSGIGRGFIIEKLIQEGIE
                     ISESKVRKVLSYLSECGYISSKSGRGGSQITSEGIKLYNNIN"
     gene            13829..14074
                     /locus_tag="KNP36_000567"
     CDS             13829..14074
                     /locus_tag="KNP36_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03905 family TSCPD domain-containing
                     protein"
                     /protein_id="HBF0872458.1"
                     /translation="MKYKTTGTCATEIEFEVKENKVTNVNFIGGCDGNLKGLKVLVEG
                     MNIEDVIQKLKGIECKTKPTSCPDQLSLALENYMNIK"
     gene            14109..14834
                     /locus_tag="KNP36_000568"
     CDS             14109..14834
                     /locus_tag="KNP36_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HBF0872459.1"
                     /translation="MKPIIGILGNLIIMENGMFPGLERSYVNNDYINAVLKGGGSPVI
                     IPVNTDKEVIKKQIEMVDGVLISGGWDINPQLYGEETREETTFIYPEVDEFDLIAISI
                     ALELKKPILGVCRGLQILNVSLGGTLYQDNNLIEGSYIKHTQSSKRHVATHKVDVKEG
                     SILEGILGKQLLTNSYHHQSVNQLGKGLKAIAYSKDGIIEAIEKEDENFVVGVQWHPE
                     MMVDYCDKMEKLFKYFINICSNL"
     gene            14856..16169
                     /locus_tag="KNP36_000569"
     CDS             14856..16169
                     /locus_tag="KNP36_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0872460.1"
                     /translation="MNEKNKMGLISIILLGINAVVGAGVFLLPGDAMKSFGVASIFVY
                     IFDMLLVLSMAFCFAEVAGKFNKNGAAYVYTKEAFGDFCGFEVGLMKWVIGCISWGAL
                     IVGFPTSLSAVWAPAGEPHIQKIIIVAMIVGLTIINLLGVSLSKIVQNVITVGKLIPL
                     ILFIGIGIFFIKGVNFTSSTMVPPGAGATEFGAAALLMFYSFTGFESIAVAAEDMENP
                     QKNIPIAIISVIVIASIIYILNQVVCVGILGDSLSSTSTPVADAARICFGNMGAGLVT
                     FGTLVSVGGICMCGAFVNPRSCVALADDKMLPRIFARKDKKGTPYVAIIATMLITIPI
                     ALSGSFAELAAISAVARFIQYIPTSLSVLVFRKKRPELVGTFKTPFGAVIPLIAVCVG
                     TWLLFQASMHQLIMGLGALAIGVPLYFIMKSYNRKIYGENLKKIV"
     gene            16375..16914
                     /locus_tag="KNP36_000570"
     CDS             16375..16914
                     /locus_tag="KNP36_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0872461.1"
                     /translation="MPTITLKNGVDVLIREGVREDAQSIIDFYNEVGGETHFLSFGKD
                     EYKISLEEQENAIESAKASDNSVKLIAFIDGEIVGIATIDSNQKAKGKHVGVLGIVVK
                     EKYWGIGLGKRLMLDLIEWCKSNGITKKITLVTNEENYNAIGLYKKVGFEVESILKKE
                     CYYNGVYTDLIGMSLLLGI"
     gene            17003..18988
                     /locus_tag="KNP36_000571"
     CDS             17003..18988
                     /locus_tag="KNP36_000571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-1,6-bisphosphatase"
                     /protein_id="HBF0872462.1"
                     /translation="MKNLCKISDDYLNSKLKYLKLLSKQYPSISKASTEIINLEAILN
                     LPKGTEHFITDVHGEYEPFVHVLKNGSGVIKRKIEELFSNTIRDSEKKMLATLVYYPE
                     QKLDLIIKQEENIDDFYRINIYRLIELCKYASSKYTRSKVRKLLPENFKYIIEELLHE
                     HVKSEHKEEYYKSIVETIVDIGIAKEFIIAISTVIQKLVVDRLHVIGDIYDRGPRPDI
                     IVDKLIEHHCVDIQWGNHDILWMGAASGEKTCIANALRISARYANLDIVEDIYGINLL
                     PLATFAIEMYKDDPCKEFIPKVNDQSVTTTEKSLMAKMHKAISIIQFKLEGEVIRRRP
                     EFEMEHRLLLNMINYDEGTINLKGKTYKLKDTYLPTIDKKDPYKLTMEERNVIDKLVS
                     SFRGSEKLQKHVSFLFSKGSIYLKANSNLLIHGCVPLNEDGSFMSMNIMGKEYKGKAL
                     MDKMESLAREGFFFKDKAEEKLYGMDIMWYLWTGKCSSLFGKDDMTTFERYFIAEKET
                     HKENKNPYFKLRENEMACKRLFEEFDLELDESHIINGHVPVESKNGESPIKANGKILV
                     IDGGFSRAYQKTTGIAGYTLIYNSRTLQLVSHEPFNSAEEAIANESDILSTTVVVEHK
                     AKRKMVRDTDEGIKIQEEIEDLKLLLMAYKKGLIKEM"
     gene            19212..20180
                     /gene="spoIIIAA"
                     /locus_tag="KNP36_000572"
     CDS             19212..20180
                     /gene="spoIIIAA"
                     /locus_tag="KNP36_000572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AA"
                     /protein_id="HBF0872463.1"
                     /translation="MNKLSDEIINSLSTTIREKVEKVSNNNLNIEEIRLRSQKPLILN
                     ANSKDYFYNQKTMTLDLNQQNSYVVTREDVEQTFQIICKYSIHSFMDDIKKGFITLRG
                     GHRVGLVGKAIVEDGQVKNIKHISSLNIRVSREIIGCSDKILSHIIKGKNQINNTLII
                     SPPQCGKTTLIRDIVRNLSNGNEDYGFKGLKVALVDERNEIAGAYLGVPQMDVGIRTD
                     IIETCPKDLGITMLLRSMSPNVIVTDEIGSEKEIKALYTALNGGIGLITTVHGDSIED
                     IQNRKELNRLLDKELFKKVIILSAKRGAGTIEKIYDLEEKRWYFAN"
     gene            20170..20691
                     /locus_tag="KNP36_000573"
     CDS             20170..20691
                     /locus_tag="KNP36_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AB"
                     /protein_id="HBF0872464.1"
                     /translation="MQIKIIIIAFLIGSSYLIGEQIYKTYTRRHKQLNDLIRVLEILR
                     MDLSFGLYTLEEIFNRIGGNKEFCFWKFFYQISEGLHNEQSKTLEIIISENIDVLSKE
                     TYLGNKEIEELKNLILTLGKSDIESQQRMIDLSIENLKKQTYETKEDINKKGVLYKKL
                     VTFIGIGICIILI"
     gene            20708..20905
                     /gene="spoIIIAC"
                     /locus_tag="KNP36_000574"
     CDS             20708..20905
                     /gene="spoIIIAC"
                     /locus_tag="KNP36_000574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018589775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AC"
                     /protein_id="HBF0872465.1"
                     /translation="MEISLILKVAGVGILISVLNMILEKTDRKDWAGLTTLAGVIIVL
                     GMVITEISDLFNTVRTMFQLY"
     gene            20921..21307
                     /gene="spoIIIAD"
                     /locus_tag="KNP36_000575"
     CDS             20921..21307
                     /gene="spoIIIAD"
                     /locus_tag="KNP36_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AD"
                     /protein_id="HBF0872466.1"
                     /translation="MEIMQLIGIAIISTTLCLVIKKDRPEIANFIAIITGVIILLSVM
                     FKLNFIVDSIQDLANKANIPTMYISLIIKLIGIAYLMEFAIQLCKDCGEGNIASKLEF
                     GGKIIVMSMSFPILLSIVEMVVNIIP"
     gene            21392..22597
                     /gene="spoIIIAE"
                     /locus_tag="KNP36_000576"
     CDS             21392..22597
                     /gene="spoIIIAE"
                     /locus_tag="KNP36_000576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AE"
                     /protein_id="HBF0872467.1"
                     /translation="MKKRFLPMIIGFLFTFFFVNIFAIMIFANEVPSSEDKEYGETKN
                     SIDKYIDGQLDKLDINEIQDYINKEIVINDVNLKSFVKDLISGEKNILDLFNKDGLKI
                     LMFDEFKASLKVVAVILVLALLSSILKSLENSFSSGAVSQIATYIIFITMVSLTLIGF
                     KDVLQICYDAIDHTVGLMQVIMPILITFLLLIGFPITSTTLNPIFIGGVTFINVFFKN
                     FLFVSITVAFGILIINNLSKNIRLKRFFSFVKQINYVSIGAMFTVYLGLVSIQGLYVT
                     SFDKFSVKTAKFAIGNFIPVVGGFVSDSVDILLSSSQLIKNIFGGIGLILLVGICLLP
                     VIKILSVIVVYKLAAIIVEPVGEDGISNFLNEVANLMIIMLASVIAITVMFFVTVAIL
                     TSISVVSQG"
     gene            22657..23274
                     /locus_tag="KNP36_000577"
     CDS             22657..23274
                     /locus_tag="KNP36_000577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AF"
                     /protein_id="HBF0872468.1"
                     /translation="MLEGIKAWIVSVLIGAFIVNIVDMILPSSKIKPYVNLVLNFMFV
                     FIVITPVVGFFSKDMSLEDRILKSMGNYNKQYVDSTNALAKETGNNSLSKGYEDGLKE
                     VLKLKLDEYGYDLEDIELNGANINNIKIKEKNNSAKSNNSSNEENKNNSTKREEENIN
                     SNDKENSKQVFKKGTEYGLNLNEEKLKNDLIKVLDVSIEDIQIDK"
     gene            23286..23840
                     /locus_tag="KNP36_000578"
     CDS             23286..23840
                     /locus_tag="KNP36_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage III sporulation protein AG"
                     /protein_id="HBF0872469.1"
                     /translation="MLKNLNDKDKRKVYSLITIAGICVVSLVLLSCFPSSKSDKQVGK
                     TETNKNAEKQVTKEQEKDDLESKLTAILSKIDGAGDVDVMVTFESSEEIQPAFNSNNT
                     TETTEEKDAQGGERTVTTSSENKTMITSNSSDPVVIKTTEPKIKGVIVVASGASDPSV
                     KETLYSAVQTSLQVAGHQVEIYSK"
     gene            23867..24556
                     /locus_tag="KNP36_000579"
     CDS             23867..24556
                     /locus_tag="KNP36_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SpoIIIAH-like family protein"
                     /protein_id="HBF0872470.1"
                     /translation="MKFNYKGRGFVIITLTAMLVVVGTVNYQLSKKSLLETSKEFKAY
                     EEAQLQKNTDESDSSKTEDSSNVDKQDGKESADIDIVDSKASKVKEKATETSKEIKAQ
                     LSSEKNMKKASYILDMKMNREKQRNELVQDLNEMINNPSTTEESRKEASNMKLNIVKI
                     QEKELQIENLLSTKGYEEALVYISDNKVNVVVNEAKLEKKDAAKIFDLVAEQANVKYE
                     NIKLTNNNSNK"
     gene            24666..25028
                     /locus_tag="KNP36_000580"
     CDS             24666..25028
                     /locus_tag="KNP36_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HBF0872471.1"
                     /translation="MEDNKFGQVKISNDVIATIAGLAALEVEGIETTATLTDKLLKNN
                     GVKIQIEEEDVNLDVMVTIKYGMSIPDTAFKVQENVKNTVETMTGLKVSQVNIHIQGI
                     SFKKDKVDKEEAKATKKN"
     gene            25113..25619
                     /gene="nusB"
                     /locus_tag="KNP36_000581"
     CDS             25113..25619
                     /gene="nusB"
                     /locus_tag="KNP36_000581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HBF0872472.1"
                     /translation="MKKDRAQKSTTREYIMKLIYQININKEDFETLEDKVDNFLKDNS
                     EHIINRYKELALQYSKNTNLKLEDTEIEDVIDKKYINTVCKALKENHDKIDELINKHA
                     KNWTVDRMPKVDVSILRLSVCEILYLDTPNKVSINEAVELAKIYCDDKSPKFINGILG
                     SVVDEIGK"
     gene            25603..26673
                     /locus_tag="KNP36_000582"
     CDS             25603..26673
                     /locus_tag="KNP36_000582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-sialoglycoprotein endopeptidase"
                     /protein_id="HBF0872473.1"
                     /translation="MKLGNNIIIGIDTSCYTTSIAAISLDKKVIFNEKIMLEVRDNSK
                     GLRQSEAVFQHINNLGILSDRIKSFKDKFNVEGVCSSKKPRPVENSYMPVFNVGHNFG
                     KLLSSIYGCRFYETTHQENHIEASLLNSKLKNNNKFISVHMSGGTTEILLTSKQDSHH
                     NVCDTNLGKIAKISIKKDDKSKLYNNFGYNIDIIGGSKDISFGQLIDRVGIKLGYKFP
                     SGKYLDENALNCNLKIESGLKTSVRDGYMNLSGLENQVNKIINDNGDNTNQKEYISKL
                     VLDSVVRNMFKSLVYLCETYNVNEVVFAGGVSASKYILRELSMKLRKKHIEAYFTEPQ
                     YSTDNAVGCAIIGLNNFLGERV"
     gene            26670..27875
                     /locus_tag="KNP36_000583"
     CDS             26670..27875
                     /locus_tag="KNP36_000583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HBF0872474.1"
                     /translation="MKLRALDISEANSYIKRILINDPILSNLKVKGEISNFKVHSSGN
                     VYLSLKDETSKLNCVIFKSNFNRNLKLDNGVKIIANGYISVYERDGAYQLYINEIEIE
                     GIGNLHIEFNRLKEKLNKEGLFDPKYKIPIPKMPNSIGVITSPTGAVIRDIINVIKRR
                     YPKVNIKLYPVTVQGDKSAEEICEAIRFFNHMKNVDTLIVGRGGGSIEELWSFNDEMV
                     AREVFNSQIPIISAVGHETDFTICDFVSDMRAPTPSAAAEIATPSLDDINYKLGNIKS
                     RMSKSLTNQIELDQYRLETVFNKINNYLDSYTIKDKVIQLDKIYDKIIFGIENNLKLE
                     DEKLVKIGALLHNLSPLATMDRGYSITQKNGKVINSIKGLKIKDSIDIVLKDGNLECM
                     IDKIENKEG"
     gene            27877..28092
                     /gene="xseB"
                     /locus_tag="KNP36_000584"
     CDS             27877..28092
                     /gene="xseB"
                     /locus_tag="KNP36_000584"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HBF0872475.1"
                     /translation="MNLTYEEAYKRLESILSELESKNASLDESLSLYEEGISLYKHCN
                     KLLDDAKLKISKFNQLGIEEDFKIEEE"
     gene            28095..28982
                     /locus_tag="KNP36_000585"
     CDS             28095..28982
                     /locus_tag="KNP36_000585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HBF0872476.1"
                     /translation="MEFKQCLKEKASFVEKVLKEYMPKEEGYQKTVIEAMNYSLSAGG
                     KRLRPILTLEACKIVGGNEDEAIPFAIAIEMIHTYSLIHDDLPALDNDDLRRGRPTNH
                     KVYGEAMGILAGDALLNYAFEVMLAGSINKENPEKYLKAINEIAKGAGIYGMIGGQVV
                     DVESENKQIGKEKLDYIHMNKTAAMMVGCMRAGATIGGANSEQMEEITKYAKNIGLSF
                     QIVDDILDIVGDEAKLGKKVGSDIENHKSTYPSLLGLDKSKEIAHNLIDEAKKSIEKL
                     SDDVDFLKGLAEYIIDREY"
     gene            29012..29449
                     /locus_tag="KNP36_000586"
     CDS             29012..29449
                     /locus_tag="KNP36_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divergent PAP2 family protein"
                     /protein_id="HBF0872477.1"
                     /translation="MDFFSEIFNNGALGISLIACFLAQFIKIFTGKEKRIELSRILIS
                     GGMPSSHSSFVTSLATVVGIEKGFNSTDFAIITVLALIIMYDAAGVRRAVGKQATILN
                     QMVADIQHGKHIEQKKLKELIGHTPLEVWFGALLGIVTALILM"
     gene            29483..31348
                     /locus_tag="KNP36_000587"
     CDS             29483..31348
                     /locus_tag="KNP36_000587"
                     /EC_number="2.2.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="HBF0872478.1"
                     /translation="MYKYLDKVNSPKDIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHL
                     ASNLGVVELTLALHKVFDSPKDKIVWDVGHQSYVHKIVTGRKDCFVSLRQFNGLSGFP
                     KENESPHDIFDTGHSSTSISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQ
                     LGYIDTNMIVILNDNEMSIDKNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEI
                     LSKTAHRFKDKLMYSFSPQDCSFFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVL
                     LHVITKKGKGYRFAEEQPDKYHGVSKFDIKTGVTSAKVKSMSISVGEKLVDMANSNEN
                     IVAITAAMPSGTGLNLFESAYPKRYYDVGIAEQHATGFAAGLAKNGMKPYFAVYSSFL
                     QRAYDQVIHDVCITKKPVTFLIDRAGLVGNDGETHHGMFDLSYLNSIPNIVVMAPKDT
                     REMELMMDLSLKLDCPLAIRYPRGSSYYLDKGEYGEIVLGKYEVLDDGQDTVILCIGS
                     MVKHALEAKEILSREGINPTIVNARFLKPIDEGMLKALLKNHKNVVTIEDNIVTGGFG
                     SRINKFIIDNEYNVNILNIAIPEEFVKHGNIDELYDFVGLSPKSIADKIRKLVIE"
     gene            31481..32293
                     /locus_tag="KNP36_000588"
     CDS             31481..32293
                     /locus_tag="KNP36_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family rRNA
                     (cytidine-2'-O)-methyltransferase"
                     /protein_id="HBF0872479.1"
                     /translation="MKKRIDLLLVEQGYFESRERAKKAIMAGLVFVDNQRCDKAGTEV
                     KEDCSIEVKGNPIPYVSRGGLKLEKAMKNFDLTIDGKVCMDIGASTGGFTDCMLKNGA
                     IKVFSIDVGYGQLAWKLRQDDRVVCMERTNIRNVTIEDTKQFADFASIDVSFISLKLV
                     LPKAKELVRHDGEVVALIKPQFEAGREKVGKKGVVREKSTHIEVIKMISDFSVENGFE
                     ILGLDFSPIKGPEGNIEYLIHLRNGNEGYEFDGETYNNKIVEVVEASHNLDK"
     gene            32313..33992
                     /gene="recN"
                     /locus_tag="KNP36_000589"
     CDS             32313..33992
                     /gene="recN"
                     /locus_tag="KNP36_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HBF0872480.1"
                     /translation="MILELYMKNCALVEELRLNIDKNLNILTGETGSGKSIIIDALGL
                     CLGDKYDRSFLRKGTDKGLVEAVFFSDNRYLKKILEENDISMEDDNLLVITRLIYSDG
                     KSTARVNGRTVKVSLLKEIASTLIDIHGQHQNQALFNKDTHLKFLDLFGENELEEFKI
                     AYKNVYHKYSEVKKALNCLTENKDEMQIQREIDLLRFQINEIEAANLNKNEYEDLLKQ
                     REVYRNSEKIYNNLNSSYSKLHNGEYNVIDLIGLASKELNDISKYDSVLSEYSDTVER
                     IMYELQDISGEIRNYKDNIDFEPYELEQIELRIDEINNLRRKYGDSIDDIFEYYGKIK
                     DRLDEILNRDERVEQLRSKLMNIEEDLKIKASKLTKARIEVATTLEKILLDELKSLNM
                     KNVMFKVNFEKGPFTLDGVDDIEFMISFNLGEDIKPIYKVASGGEMSRFMLAFKTILA
                     DIDDIDTLVFDEIDTGISGIAAQIVGEKLSDIAKKKQIICITHLPQIAANADTHYCIE
                     KDTSNNRTFTNVSKLNESQRKNEIARLIAGNNITEKTIEHASEIIELAKKC"
     gene            34206..35072
                     /locus_tag="KNP36_000590"
     CDS             34206..35072
                     /locus_tag="KNP36_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872481.1"
                     /translation="MNKKDTMHLIFTIVIFILLWYIVVAVSEINKNIESCSNKLDYLS
                     QEIMSTKSDISNTINEEMSKSYITKSIDLKVKKIEKKECVIDVDVQLSKLGKNGKVFF
                     MYKEDSDKWNETEMTKHGELSYACEIKINTGSEYDYKVVTSGAISESSDVQKLTKSDY
                     MPEQPIFNSGIRDNREYFIEIVENSNLFNHESEKSKNKVYDNIRLEKVDIIVNEGKKD
                     TIYKAKLAEGLDDGKTNNSNRNQVNYEVSFPKRDIDDIIYIKAKLTYNNGVEYTKDIT
                     EDITMGLQDLEK"
     gene            complement(35165..35656)
                     /locus_tag="KNP36_000591"
     CDS             complement(35165..35656)
                     /locus_tag="KNP36_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0872482.1"
                     /translation="MADKMAQNITLQFVEEKDLENLENVKLLFTEYSNSLNIDLCFQD
                     FNNELKTLPGKYKKPSGSLILAFVDENLAGCVALKKLEGKICELKRLYVRNQFRGLKI
                     GKILLEEIIEEAKKFGYTHMRLDTLPSMKSAQGLYEKFGFYDIEPYTYNPIEGARYME
                     LKL"
     gene            complement(35717..36157)
                     /locus_tag="KNP36_000592"
     CDS             complement(35717..36157)
                     /locus_tag="KNP36_000592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0872483.1"
                     /translation="MKLNVRIADINNWHDLVSLSVDKSQLDYIESNALSIAESKFITA
                     WVPVGIYDENSLIGFAMYGRLEDDRVWLDRFMIDSKYQGKGYGKASLDFLVNHLKNEY
                     NCDELYLSIFEDNKMAIKLYKDFGFEFNGELDYGGEKVMVLKSN"
     gene            36318..37376
                     /locus_tag="KNP36_000593"
     CDS             36318..37376
                     /locus_tag="KNP36_000593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S55"
                     /protein_id="HBF0872484.1"
                     /translation="MNKINKNFKNIWIILGAVSIFTMVIIFNKNCNVNKETQIEAFTI
                     KNHDKKFVYPMGNIIGVKANTDGVLVLGYEEEDVDYIGGIQIGDNIVKIDNKRIKNSQ
                     DVSEILNKIKKSKVEVTFERKNKYKTEVIETKKENGKYKLGLWVRDKISGIGTMTFYD
                     PSMEKFKAIGHAIKDSDTNELLKIKQGYIYKPEQLKIVKASNEKVGKIKGDFNDSNLM
                     GNFSNNSELGISGNITENHNKEFNVANKEKQLIEVGRPQDVKIGDAVILFEDKNKNIT
                     SYDIKIESIVYDKGNYRDMVIKVVDDKLLEYTGGIVQGMSGAPIIQNNKIIGAITHVF
                     RDNPKKGYGIFIDEMIKL"
     gene            37518..38342
                     /gene="spo0A"
                     /locus_tag="KNP36_000594"
     CDS             37518..38342
                     /gene="spo0A"
                     /locus_tag="KNP36_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="HBF0872485.1"
                     /translation="MGGFLVEKIKIVLADDNKDFCQVLKEYLSNEDDIDILGIAKDGI
                     EALDLVKKTQPDLLILDVIMPHLDGLGVIEKLNTMDIPKMPKIIVLSAVGQDKITQSA
                     INLGADYYIVKPFDFVVFINRIRELVSNRVTQVEPKPRPVQETQMTRSDFVKNVGNIE
                     TEITNIIHEIGVPAHIKGYLYLREAIKMVIDNVELLGAVTKELYPSIAKKFNTTPSRV
                     ERAIRHAIEVAWSRGKVDTINQLFGYTVHNTKGKPTNSEFIAMIADKLRLEHSMVK"
     gene            38755..39876
                     /locus_tag="KNP36_000595"
     CDS             38755..39876
                     /locus_tag="KNP36_000595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872486.1"
                     /translation="MRVEAPIKVDRKTKKLAKRVESGEIAVINHIDIDEVAANSLVEA
                     KIKLVINAAPSISGRYPNKGPGILTENNILIIDNVGEELFEELKEGETIEVVDGKIYR
                     KGKFLGAGEVLDKYEVSHQIKAAYENLAVELDRFIDNTIDYAKKEKGFILGEVEIPKV
                     KTNYANKHVLIVVRGQDYKEDLSTMLSYIEEVKPVLVGVDGGADALIEFGYTPDVIVG
                     DMDSVSDEALKKASEIVVHAYTDGRAPGLKRVEELGLDAVVFPAPGTSEDIAMLIAYE
                     YKAELIVAVGTHSNMIDFLEKGRKGMASTFLVRLKIGSKLIDAKGVNLLYRSKLKIKY
                     IWALIATALFPVLVVASLSPGVQQFIQLMQLKFRVLLQM"
     gene            39894..40769
                     /locus_tag="KNP36_000596"
     CDS             39894..40769
                     /locus_tag="KNP36_000596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper transporter"
                     /protein_id="HBF0872487.1"
                     /translation="MHINMKYYIVTIGAIFIALGIGMLVGFNLNNNQQLSEQQANIIN
                     DLDDKFNILKEKNDKLDSDLASVNRDYEEAVNFINKNVDKILAGSLNGKSIGIISANE
                     NDDYTKNIEDIINKSNGSIAFNIILKENITNPEKLKEMSTKLGTDVKNANDAVNYIID
                     TLKKEDASDILTYLQELDVIKFNFIGDTYLKYDSVVIAGGNDAKDSTKQFEKIEKFVV
                     SKLKSENKYLVEVQNTGVKTSYVELYSKNKVATIDNIDEGIGSISLAILLQQGNIVGN
                     FGRLDTATSLLPSIK"
     gene            40793..41485
                     /locus_tag="KNP36_000597"
     CDS             40793..41485
                     /locus_tag="KNP36_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0872488.1"
                     /translation="MDSYISIIIPAYNEESRIKYTLESILDIKQINEIIVVDDGSIDN
                     TAKVVSELENEKIKFFKLDKNRGKGYALNYGIKLAMKNADIIGFLDGDLGSSAKEVEK
                     LIVPILNGEADVTIAKFPPAKRKGGLGFVKGLAKNSVFEMTGVELDATLSGQRIFKRE
                     VLEKFDEIPFGYGVEVGMTIDILKYGFKIKEVLVNMTHNETGRNLKGFIHRGKQYYHI
                     KKVLGQKKKEWR"
     gene            41493..42317
                     /locus_tag="KNP36_000598"
     CDS             41493..42317
                     /locus_tag="KNP36_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBF0872489.1"
                     /translation="MKDYILYTILLLTGLFGTYAVIPLFKNLLINGNVLRPNYKKDMI
                     PVSMGIVFLPMIVINGIILAFFTTEFKNLAYIFMFMFGMISMFFAGILDDVIGNRDVS
                     GLKGHFKSLFKGSLTTGGFKALFGGFVGLIVSVAISKDIIDIIVNTLIIALSTNLMNL
                     LDLRPGRAIKAYLFIMVIVFLTLTGFVQVLPLLIVPNVLAYFNYDLKARAMMGDTGSN
                     VLGISIGMLISFGYPFNIRLGWLIFVVIMHIFTEKYSLTKIIEKNKLLNFIDKLGR"
     gene            42322..43389
                     /locus_tag="KNP36_000599"
     CDS             42322..43389
                     /locus_tag="KNP36_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3866 family protein"
                     /protein_id="HBF0872490.1"
                     /translation="MISKRVGIVESIVSQTETLDDIRVNINGEIQKAYNYPKISGTIN
                     IGDEVVLNTTAVELSLGTGGYHFVITNLNNIESTLTEGGHIMKLRYTPLQIKVDSVEE
                     QESIYHDKFANFKGLEGLSVVVGTLHSMLTPFAASFKRNNPNKKLVYIMTDGASLPIY
                     LSKNVDTLKEKKLIDSTITIGNAFGGDYECINIYTALITAKEILKADAVFVSMGPGIA
                     GTGTKYGFTGIEQGSILDAVKKLEGRAIAIPRISFADKRERHQGISHHSMTVFKEIVN
                     VNVDIPITIYDDEKLNFIKEQINLNGLDKKHNIIYIDNNKTKEDLDYFNLKVKSMGRN
                     YEQDEAFFKAASTAAYYLMEV"
     gene            43391..43927
                     /locus_tag="KNP36_000600"
     CDS             43391..43927
                     /locus_tag="KNP36_000600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBF0872491.1"
                     /translation="MVLEEKTISSDRVYTGKVITLKVDTVEIPGQGYQKRELVEVGGA
                     VGIVAITDDNKVVLVKQFRKPIEKPIFEIPAGKLEKNESPKECAERELKEETGYSAKN
                     IKLIHKFFTSAGFSNEIMFVYLATGLTPGENNLDADEFLDVYEIELEEAYNMVLKNDV
                     EDAKTSIGLLLVKDMFKN"
     gene            43995..44600
                     /locus_tag="KNP36_000601"
     CDS             43995..44600
                     /locus_tag="KNP36_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein M"
                     /protein_id="HBF0872492.1"
                     /translation="MRRTYRKNDFRELNRQIIIIGLLFMMSIVVGSYINKILPGSSNN
                     ILNNINPAVEYYNLNISIKDTVIQNLKSDAIFMGSIALLSLFVVTIPAVLVAFVLKGM
                     SIGYTINSCILALKFKSIKMILIILFKNLIIIPCAIILALISLSYFKEMVYEFKKKSR
                     KNMQFLIKRYILNIIIIIALSLGLQLILNTASIGIIKFLAK"
     gene            44612..45526
                     /locus_tag="KNP36_000602"
     CDS             44612..45526
                     /locus_tag="KNP36_000602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBF0872493.1"
                     /translation="MDIIEGYIDYIKDKKKLSENTVASYFMDIKKYMEYINQKSIKLV
                     DIVENDIISYLIKLEKDNVSIATIARMISSIKSFHDYLFLNHICTNNPAKDIKKPKIK
                     KENINILTEEEIERLLNFPKLTTPKLIRDKAIFEVLYGTGIKVSELVEMNIEDIDLDI
                     DYIYCNSCCKNQRVIPLCDITKLYLEKYLKEARPKMAAEGEKSLFVSSLGQRFTRQGL
                     WKVIKKYSNLANIDKNINPTMLRHSFAIHLLNEGANIAVVSKILGNVNLSSLQVYLNH
                     IDKNVRREIKEKHPRNDVDVELQKAEAK"
     gene            45568..46740
                     /locus_tag="KNP36_000603"
     CDS             45568..46740
                     /locus_tag="KNP36_000603"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HBF0872494.1"
                     /translation="MSRVIWIVIDSVGIGALPDAEKFGDSKDVSTLGNIFKEYPDIQI
                     PNMRNLGIGNIEGIDFFESIKEPIGCFGKCKEMSQGKDTTTGHWEMTGIIVDKPFKTF
                     EHGFSKEIIEEFEKKTGRKVVGNKPASGTVIIDEYGEHQIKTGDVIVYTSADSVFQIA
                     ANEEVIPLEELYNMCKIAREIMMGDNAVARVIARPFIGKKKGEFVRTSNRRDYSLDPF
                     EPTVLDNIKESGLDVLAVGKIEDIFNGKGITDAIHTKSNMDGVDETLNYMKQDNKGLI
                     YSNLVDFDSKYGHRRDPEGYKKALEEFDSRLPEIMANMREDDILIINADHGNDPTYKG
                     TDHTREYIPVMIYGNKIKKGFNLGVKDTFADIGATVADILNVKLPKHGSSFKEDLF"
     gene            46787..47599
                     /locus_tag="KNP36_000604"
     CDS             46787..47599
                     /locus_tag="KNP36_000604"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HBF0872495.1"
                     /translation="MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIK
                     YSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRFHYYEGYSQKEATFPVRVMKELG
                     VEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSS
                     KYVDVVKNCAKECNIDVKEGVYMFFSGPNYETPAEVRMAQILGADAVGMSTVPEVIVA
                     SHSNIGVIGISCITNMAAGILNQPLSHEEVIETTQKVKSEFMNLVKTTVKNL"
     gene            47803..49128
                     /locus_tag="KNP36_000605"
     CDS             47803..49128
                     /locus_tag="KNP36_000605"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HBF0872496.1"
                     /translation="MRMYDIIKKKRDNLELSKKEINYFIENYSKGDIPDYQASALLMS
                     IYLNKMNKQETVHLTEAMMNSGDMINLSEIDGIKVDKHSTGGVGDKTTIALIPLVASC
                     GAPVAKMSGRGLGHTGGTIDKLESIPGFSTEMEISKFIDSVNKSKIAVCGQSAKVAIA
                     DKKIYALRDVTATVDNISLISSSVMSKKLASGADAIVLDVKTGDGAFMKTLEESFELA
                     KSMVDIGTGMNRDTIGIVTDMDEPLGFAVGNSLEVIEAIETLKGNGPKDLVELCEVLG
                     AYMLVLSKVAHDFEDGVEKIRESIKSGTAIQKLKEFIENQGGNKDVVDDYSLFKKSKY
                     KYPVKSTKSGYISKIKAEDVGVSAMILGAGRETKDDILDLSAGIILEKKVGDYVNEGE
                     VLAYMYYNDEQKLSLAKGRFIDSYSIVDSKIEKNKLIYGIVTKEEIKKF"
     gene            49341..50420
                     /gene="mltG"
                     /locus_tag="KNP36_000606"
     CDS             49341..50420
                     /gene="mltG"
                     /locus_tag="KNP36_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HBF0872497.1"
                     /translation="MNFKENRLKIAVLIIVILIILAGIFVFIQIGPYDKNNKKDVIID
                     VPSGASVGKISDILYENKLIKNELLFKLLVKVSNKAPSIKSGTYLLNQSYSNNDIISL
                     LVSGKIYQDGIKVTIPEGATSKEIIAMLVSKNLGDKATFENLIKKPQEFYDKFSYLKE
                     DGITSLEGFLYPETYYFNSKKQSEEDILSEMLKVFDSKYTDKFKKKQKELNMTLQEVM
                     EMASIIEKEAVLDKDRPIIASVFYNRLKVGMPLQSDATIQYIFEERKKIVTYDDLKID
                     SPYNSYKNKGLPPTPISNPGIKSIEAALYPEKTDYLYFVAKIDGGNNYSTNYQDHLKY
                     VKEYKEARDKQSKDTKATNKENTKK"
     gene            50592..51266
                     /locus_tag="KNP36_000607"
     CDS             50592..51266
                     /locus_tag="KNP36_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HBF0872498.1"
                     /translation="MSNIVNDLVEDYIRVTLKEKEGFLKDLEIYAEENSVPIIHKEVS
                     DLLKVLLKVQKPKRILEVGCAIGYSSIFFATIIGKDADIITVERNEKMIEKAKENIKL
                     AGFDNNITILEGDAEEKLSQVQGEFDLIFIDAAKGQYKLFFDLVIDKLKDGGLLVSDN
                     ILYKGMVAHDDFVVRRKKTIVKRMRKYLDYICNCDYLSTSLVPIGDGVALSYKESKRG
                     DVDGIK"
     gene            51253..52500
                     /locus_tag="KNP36_000608"
     CDS             51253..52500
                     /locus_tag="KNP36_000608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HBF0872499.1"
                     /translation="MELNKVELLAPAGDLERLKIAITYGADAVYIGGEIFGMRSAAKN
                     FSKEDMAEGVAFAHERGKKVFVTVNIIPHNEDFLQLEDYLLELEEIGIDAVIIADPGV
                     LSVIKKVIPNMEIHLSTQANTTNYLSANFWYEHGIKRVVVARELSFDEIYEIRAKTPL
                     DMDIEAFMHGAMCISYSGRCLISNYMTGRDANKGSCAQSCRWQYHLVEEKRPGEYFPI
                     YEDERGTFFFNSKDLCMIEYIPELIKSGITSLKIEGRMKTAYYVATVVRAYRMAIDEF
                     YRDPENWKFNPMWMEELKKGSHRHFTSGFYLNKPTTEDQNYQSASYVRNYDFIGIVRE
                     TEDEDGLIVVEQRNKMCVGDEIEVMGPYKETMFTKIEEMYNEEGEAIESAPHPRQIVK
                     LKLSVKVGKDYMLRKVIEEKVEE"
     gene            52572..54242
                     /locus_tag="KNP36_000609"
     CDS             52572..54242
                     /locus_tag="KNP36_000609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2"
                     /protein_id="HBF0872500.1"
                     /translation="MSKKKTPFLKKVGKRSWCIFTIILIIYSVLIYRLVDIQVLKGDK
                     YKQSVESQSVEKVELNSGRGIIYDRNNKKLTDTSKSQVLIVEKEKLNNNYKILELIKK
                     ATKMNDLDIYKAVQEQLTRPIIQIQTKNIDIDKSMKKELEKNGIMVEEKTMRYAKDGL
                     LSHTIGYIKEDDKSGQSGIEKSMDSVLRNSNEKYISAFKAGDAGNEKSLNILKGSVKT
                     VDNKDKDRHLKTTIDYNIQKKLEQILNKEENPTAAIISEASTGEILAMCSRPNFDQND
                     ISKSLKGKNGEFENRVIKATYPPGSVFKMVVLFSALENGVIDENYTYNCTGKTKVGNT
                     NEILRCNKRDGHGFQNLRQAFSNSCNPAFLDIAMKLGKEKILKSAEKLHLFEKVDIGL
                     DEEKIREAPKNISIRNLAIGQENIEFTPLQINQMTQIIANNGTFKPLYLYKSLVDNNM
                     NTIKTYKSSKKEELISPYVCTQVKEYMKSVSRTGTAKDLKDIEGGCGVKTGTAQSSLN
                     KKAIDHGWITGFYPEERPKYVITVLVEGTQKGNKSATPIFKEICESIK"
     gene            complement(54339..54623)
                     /locus_tag="KNP36_000610"
     CDS             complement(54339..54623)
                     /locus_tag="KNP36_000610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0872501.1"
                     /translation="MCNEISLLDILGTEANYVLDEVELKVQVGKLYEQLNKILTPRER
                     EIVQLRYGLTPYGYKTQREIAQKLDISRSYVSRIEKKALKKLEKELVQES"
     gene            complement(54646..56163)
                     /locus_tag="KNP36_000611"
     CDS             complement(54646..56163)
                     /locus_tag="KNP36_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBF0872502.1"
                     /translation="MSVAIYLRKSRADEEAEKQGEFETLSRHKSTLLKLAKEQNLDVI
                     EIKEELVSGESIIHRPKMLELLKEVEENKYDAVLVMDLDRLGRGDMKDQGIILETFKE
                     SKTKIITPRKTYDLTDEFDEEYSEFEAFMARKELKLISRRMQRGRIKSVEEGNFIGTS
                     APFGYDAVTTGRKERILVPNKDADVVRTIFDLYINEDMGCSKISKYLNNLGIKTATGA
                     NWYNSAITNIIKNKAYCGYIQWQKKDYKKSKNPNKIKTVKLRPKDEWIEAKGKHEPLI
                     SEITWKKAQNILKKNGHVSYGNQIKNPLAGIVICKNCGRPLVYRPYADHDYIICYHPG
                     CNKSSRFEFIEAAILKSLEDTVKKYQLKASDIDLDKNNKDSNIEFQKRVLKGLETELK
                     ELGKQKNKLYDLLERGIYDEDTFIERSNNISSRTEEIKDSIKTVKNRLSTVKKDNSKI
                     IEDIKTVLSLYHDSDSLGKNKLLKSVIDKAVYYKSKEQKLDSFELMVHLKLHEDQ"
     gene            complement(56288..57109)
                     /locus_tag="KNP36_000612"
     CDS             complement(56288..57109)
                     /locus_tag="KNP36_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBF0872503.1"
                     /translation="MIISKKITAILVSFLIMISMVGCAPKESATEVAKKYLDSIEIKD
                     YEVAYNLLSKDSKESVSLEKFEEYQDTLFKLQTLKDYKLGEENKVEKYKYSNKEYTNL
                     VKIKETDTIKYITENKEDTANFDRYFIIEDNEYKLLWHKDFKRALSSNYVKIARSETE
                     KDEDKDYNKAAIDIKKAIEIDDKNPLAYYTQSYIYIELQRYDEALKSIDKYLEYLDKN
                     NEAYKIDASDAYNLRGVIFMSKSEFNKARESYNKALELNPDNEYAKTNLNDIKGL"
     gene            57300..58727
                     /locus_tag="KNP36_000613"
     CDS             57300..58727
                     /locus_tag="KNP36_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp26"
                     /protein_id="HBF0872504.1"
                     /translation="MKIKKLLTIGLSLSIFIASCPISVNALDKIESIKGADKYETAGI
                     IADKQNYTTAILINADSTMADGLSASGLAGAINAPILLTKKNNIPNATLKRLEKAKKV
                     YIIGGENSIDKYTETVLKGKGIEIKRLQGSDRIKTSYNVAKEINSINKVNKVILTNAF
                     KGEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGVESYVIGGTSSMNDKIVKDTNSTR
                     LGGTDRYDTNKKIINKFYSGVKEFYIASGTDLVYALVGSTVAKNNAIVLVDNDSNKSV
                     LKSTTKLTAIGNLSDSILQQCLNVTKNIGDSNTGREYTVEDAANAVKKLLGVKKFYYE
                     PNYSEDEDLIFLLDKNFDFSGKEYYVFAYIKQGAEGDVRYCVAKNDMSKVYTYDVNGN
                     MKVCNPDDYKNKGSITEEQAKQIALKECAKRHKVSINNLVVDMIDFRDDIYSGNVYAV
                     KINSKNSNGTFGWFFIDIETGKVYN"
     repeat_region   59683..59909
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=59683..59711
                     /rpt_unit_seq="gttttatattaactaagtggtatgtaaag"
     gene            complement(60196..60420)
                     /locus_tag="KNP36_000614"
     CDS             complement(60196..60420)
                     /locus_tag="KNP36_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872505.1"
                     /translation="MDVNQRIKYIRENMNSSQKELLEKTNINTSVMNRIESGERPTRD
                     DGLIIFAKIFGLYTDYILGLSDTEKLNIGN"
     gene            61131..61286
                     /locus_tag="KNP36_000615"
     CDS             61131..61286
                     /locus_tag="KNP36_000615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="regulator"
                     /protein_id="HBF0872506.1"
                     /translation="MALDVKIEVKIIKDVVILNITHWKKETSLLTVKIARSQGDLSYV
                     KYFANES"
     gene            61532..61783
                     /locus_tag="KNP36_000616"
     CDS             61532..61783
                     /locus_tag="KNP36_000616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872507.1"
                     /translation="MSSYFITRGDVMKILQQFKPYKYDKEKNIEYDEKIIANQNTEVY
                     IVYPRISDEENRRRWEEFNEVAKEVAINIAMKKVETVES"
     gene            complement(62993..63376)
                     /locus_tag="KNP36_000617"
     CDS             complement(62993..63376)
                     /locus_tag="KNP36_000617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872508.1"
                     /translation="MRKKFFIGILIVLIISVIAILNIKNDKNVFIGESENWKAKFVTT
                     EGHSKLEIKYKNSKDVVEQKFNYSYQFIDGEDAVVVVKNEILEAGQEKAIKIQRPGLY
                     SNRESSYKLIISWNGNEETINLKKK"
     gene            63503..63847
                     /locus_tag="KNP36_000618"
     CDS             63503..63847
                     /locus_tag="KNP36_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872509.1"
                     /translation="MNYRLKKSVTTILSLLIMTILLPTNASASKVEDSSMKVMYSEKQ
                     VTDMDKLYDMAKNGITDVKSSNEKGIIKNARTGESIYVDSISTTQLLEVKQSKNLTSK
                     IYSKTVFLILIQ"
     gene            64030..64245
                     /locus_tag="KNP36_000619"
     CDS             64030..64245
                     /locus_tag="KNP36_000619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872510.1"
                     /translation="MHINQTGFISNELGIKQQQKKEPTSNSFSYNAPSSWKPVGRDSV
                     QYNCGFELIATLVRGGSSWAFNFIVQP"
BASE COUNT        25819 a         6667 c        11514 g        20376 t
ORIGIN      
        1 aaattaaaaa acgtaaaaaa atttataaaa atgtagaaat gttacctaca taaaaaactg
       61 gttaaatgtt attaaaataa ctttattagc tctttatatt atattattat aacaaatggg
      121 aaagaataat ctacattaag ttaacttgtt aatatattat tagtgaaata cacaatttac
      181 catactagaa atatgatata atataaaaaa aaagtatata cttttatatt aaaaggtgat
      241 atattattta tgaaaatcgt ttaatgtata caataatata tctataacaa aataataaaa
      301 gatagagttt tatttagaca tttattacaa atcaaaattt attacatatt atttataaaa
      361 aaatctaagg aggaaataat aatgaaaata ttagtattaa actgtgggag ttcttcatta
      421 aaatatcaat taatagatat gaataatgaa gaagttttat gtataggatt ggttgaaaga
      481 ataggaatag aaggttctat attaaaacat gaaaaagcag gtagagatga taaatacgtt
      541 gttgaacaac caatgaagga ccacaaagat gcaatagcat tagttttaga agctgttgct
      601 catccagaat ttggtgcagt taaagaaatg aaagaaatag atgcagtagg acatagggtt
      661 gtacatgctg gagaaaaatt tgcaacttca gtagtaataa ctccagaagt agaagaagct
      721 ttaaaagaat gtatagattt agctccactt cataatccag caaacataat gggaatagat
      781 gcttgtaaag ctatacttcc agatgtacca atggtaggtg tatttgatac tgctttccat
      841 caaacaatgc ctaaatcttc atacttatat ggtttacctc atgagctata tactaaatat
      901 ggggtaagaa gatatggatt ccacggaact tctcataatt atgtatctca aagagcagca
      961 gagatattag gaaaagatat aaaagattta aaaatagtaa cttgtcactt aggaaatggt
     1021 gcttctatag ctgctgttga tggtggaaaa tgtgtagata catctatggg attcactcca
     1081 ttagaaggat taataatggg aactagatgt ggagatatag acccagctat attaccattc
     1141 ttaatgagaa aagaaggttt agatgctgat ggattggata aattaatgaa taaagaatct
     1201 ggagtatatg gaatgactgg aatttctagt gacttcagag atatagaaga tgcagctaaa
     1261 aatggagacg aaagagctca agctacatta gaagcgtatg ttaaaaaagt acaaaaatat
     1321 ataggcgctt atgctgctga aatgaatgga ttggatgttg tagtatttac tgcaggcgtt
     1381 ggtgaaaatg gaaaggctat aagagcagat attgcttcta acatggagtt tttaggaatg
     1441 aaattagata aagaagctaa tgatgttaga ggaaaagaaa cagtaatatc tactgctgat
     1501 tctaaagtaa aaatgctttt aataccaact aatgaagaat taatgatagc tagagataca
     1561 ttaagattgg taaaataatt aaattaaacc tatgcctatc aagtaaaaat acttgacaaa
     1621 caaatgctag atttgtataa taaatttggt gatatgttga ggtgaactta atgaaagtta
     1681 gcatagaaaa aataaataga aaagaaactg acaaaataga cttgaatttt tgtgaaaaaa
     1741 ttgatactat tagttattgt gatgagattt acaaattagt atcacctgta aatttaaaag
     1801 ggaaagtgtc aaagactaat aaaggtttgt atctagatat agatgtcaat tttacaattg
     1861 ttgacaattg ttcaagatgt cttaaagaag tagaaatacc actagagtat tctatacaag
     1921 gttttttagt aaaagaagaa gattatgatg aagatgagtt tgaggaattt gatcctttta
     1981 tattcgatgg tgaagaaatc gaccttattg atataataga acagacatta gattttaatg
     2041 tacctcataa agttctttgt agtgaaaact gtaaaggtct ttgtcaagta tgcggggcaa
     2101 acttaaatga agaagagtgt tcttgcagtg aaattacaaa cgatgaggaa tacatagatc
     2161 ctcgttttgc taaattaaaa gatttattta attaaatttt gactaaggag gtggcgtaaa
     2221 tggcagtacc aaagcgtaaa acgtctaaat caaacacaaa aatgagaaga gcagctaact
     2281 caaagatgga agcaacagga tttgtaagtt gcccacaatg tcatgagcca aaattaccac
     2341 atagagtgtg tccagactgt ggatattata aaggtaaaga agttgtgtct aagtaatagc
     2401 ttctaaaaag catgtagagt atactctaca tgtttttttt gtacatataa aaaaataaga
     2461 taatttacta gagaaaataa gtggatttta tgcatattaa aaaatagaaa aataataata
     2521 taagtattga aaatttttgt gtgttactat atactactat tagtagctgg tactaattac
     2581 agctataaaa tttggaggga acatgaaaaa gaaaagtaaa gcccaaagac aaaaagagct
     2641 tatagatatg ctaaagacag atccttttta tactgatgaa gaattatcaa gtctgtttga
     2701 tgtaagtata cagaccataa gattagatag aatgagtcta aacataccag agctaagaga
     2761 aagagtcaaa tcaatagcag aaactcagag ttcaaaagta aagactttag gagtaaagga
     2821 aattacagga gaaatcattg atttatctgt agggcgatta ggtatatcta tgttagaagt
     2881 tacacaggac atgatttact ctaagactaa tactttaaaa gatacgtata ttttttctct
     2941 agcagattca ttggcaatgg ctataataga tgcacctaag gttattatga gagttgcaaa
     3001 tgtaaaaagt tttaagttga tagaacaaca agataggctt atagcaaaag cagaagtgta
     3061 tagaaatata gataaaaagc attatgtaaa agttgttatc aacaataaag cccaagagca
     3121 aatatttaga ggaaagttta tctttgaaga attagattag gagggaaatt atgaaaatag
     3181 taattgatgg aatgggtgga gataatgcac ctaaatctaa tgtagaaggc gcagtaaatg
     3241 ctataaaaga atatcaggtt gatttaataa tcacaggaga taaagattta cttgaaaagg
     3301 aattttcaaa ttatgaattt gatagaaata aattagagat agttcatact actgagatta
     3361 tagaaaacga agataaacca gtaaaggcta taagaagtaa aaaagattca tctatggtag
     3421 tagcattaaa tcttgtaaaa gaaggaaagg cagatgctat aatatcagct ggaaatacag
     3481 gagccttact tgctggtgga ttatttgttg ttggtagaat aaaaggaatc gatagacctt
     3541 gcttatgttc agcaatacca aatgtaaagc gaggaatgac acttatagca gactgtggcg
     3601 caaatgcaga ttgtaaacct aagaatctag ttgaatttgc agctatgagt aatatttatt
     3661 caagaaaagt tttaggtctt gaaaatccta aggtagcatt agcaaatgtt ggactagaag
     3721 aaggcaaagg caatgattta gtcaaaaggt catatgaaga aattaaaaaa ttagatttaa
     3781 attttatagg gaatgtagaa gctagagaag ttataaatgc atacacagat ataatcatat
     3841 gtgatggatt tacaggtaat atattactta aatctgctga aggtgtagca ctttcagtta
     3901 tgagtcttat aaaggaaact tttatggcca gtacaaaaag taaaatagga gcattactta
     3961 taaaggatga tttaagaaaa ttaaaaagtt ttatagatta ttctgagtat gggggagctc
     4021 cacttttagg tctaaatgga ggagttataa aagctcatgg tagttctgat gctaaagcta
     4081 taaaaaatgc tataaatcaa ggaataaaat tttcaaaggg aaaagtcgtt gaagatatta
     4141 accaatttat aagcaaatac aatgaagaaa ataaaaataa cgaagatgaa taaactcgtt
     4201 ttggaggttt aatatataat gaatacaaag gctggaatat taggagtagg aagttatcta
     4261 cctgagcaat catatgataa ttttcacttc gaaaaaataa tggatacatc agatgagtgg
     4321 ataagtacta gaactggtat taaggaaaga agatttgcca aagagtctga agcaacttct
     4381 gacttagcat ctaaagctgc cttaaaagct atagaatgtg caaagttaaa cgtagaggat
     4441 atagagctga ttatattagc tacaattact cctgatatgt ctttgccttc aactgcatgt
     4501 atagtacaag atgcaatagg agcagtaaat gctactgcat ttgatatatc agcagcttgt
     4561 tctggatttg tatatggagt aactattgca aagcaatttg tggaaacagg ttgctataaa
     4621 aatgtgcttg taataggagc agaaacttgt tctaagtttt taaattatga tgatagaaca
     4681 acagcagtat tgtttggaga tggagctgga gcagctgtta ttggccctgt aaatgagggt
     4741 ggaatactgt ctacacatat gggctctgat ggtaaaggaa aagattgttt aaaagtacct
     4801 gctggaggtt caagacttaa ggcaagtaaa gagactgtag aagctaatct acatacaata
     4861 gaaatggcag gtagtgatgt gtttaaattt gcagttagaa agatggcaga aacttcttta
     4921 agagctcttg aaaaagcaaa tctaaataca actgatatag actacttagt gccacatcaa
     4981 gctaatataa gaatcataca agcttcttct aagagattag agcttgatat gaaaaaagtt
     5041 tatgtaaata tagacaaata tggaaatatg tctgctgcat ctataccagt agcattagat
     5101 gaagcttata gagaaggtaa aattaaaaag ggtgataatg tagttttagt tggctttggt
     5161 ggaggtctaa cttggggggc ttcagttgtc aagtggactt tatagtataa aatatctaaa
     5221 atgatttaat taacaaaatt aaacttatac acaaaataaa gttgattaat aataaaaagt
     5281 ttacttttat gatttcaagt gaaggagaat tgtatgaata aaatttgcaa aatattaaat
     5341 ataaaatacc cagttatcca agggggaatg gcatgggtag ctactgcatc attagcaagt
     5401 gctgtatcta atgcaggagg acttggcata atagcagcag gaaatgcacc aaaagaagct
     5461 ataaagaaag aaattgttga gtgtaaaaaa ttaacagata agccttttgg agtaaatgta
     5521 atgcttatgt cgccatttgt tgatgatata attgatttga ttatagaaga aaaagttcaa
     5581 gttattacta ctggtgctgg aaatcctgca aagtatatgg atagattaaa ggaagctgga
     5641 acaaaggtta ttcctgtagt acctacaata gctttggcac aaagaatgga aaagctagga
     5701 gctacagcag taatagcaga aggtactgaa ggtggaggac atataggaga acttactact
     5761 atggtcttag ttccacaagt tgctgatgct gtaaacatac ctgtaatagc tgctggagga
     5821 attgtagatg gtagaggaat tgcagcatca tttgcattag gtgccagtgc agttcaagta
     5881 ggaactagat ttatttgcag tgaagagtgt tctgtccatt caaactataa aaacttagta
     5941 ctaaaagcaa aagatagaga tgcaattgta acaggaagaa gtactggtca tccagtaaga
     6001 acattaaaaa ataaactatc aaaagaattt ttaaagatgg aacaaaatgg agctactcct
     6061 gaagaactgg ataaaaaagg tacaggagct ttaagatttg caacagtaga tggagacata
     6121 gaaaaaggtt catttatggc aggtcaaagt gctgctatgg taaaagaaat aacaccttgt
     6181 aaggaaatta tagaggctat ggtaaatcaa gcaagagaga ttatgccagc aatagaactg
     6241 taaatcagga ggagcaagat gggaaaagtt gcactagtat tccctggtca aggagctcaa
     6301 tatgtaggta tggccaagga tttatatgaa aataatgctg ttgctaaaag tgtaatagat
     6361 gaggctagtg atgccttaaa tatggattta aaaaacctta tgtttaatgg aaatgaagaa
     6421 gaactttcta aaactgaaaa cactcaacct gctatggtta cacatagtgt agcagtatta
     6481 aaagcggtac aagctcaaat agatttaaaa tataatgcat gcttaggatt atccttagga
     6541 gagtatagtg cgttggttgc agcagatgca attgacttta aagatgctgt atgtttagtt
     6601 aaaaaaagag gtaagtttat gcaggaaaca gttccagcag gtgttggagc tatggcagca
     6661 gttttaggtt tagatagaaa tgtacttgaa aatgtggtta aagatataca aggaggtatt
     6721 gtagaagtag caaattacaa ttctcctgga caaatagtta tatctggtga aaatgaaaag
     6781 atagaagaag caatggtaaa atgcaaagaa gcaggagcaa aaagggcagt taaattaaat
     6841 gtaagtggac cttttcactc atcaatgtta aaagaagctg gtgtaaaatt ggccagtgaa
     6901 ttagaaaaag ttaacataac taaacctaaa gttgatgtgg tggcaaatgt aaatgcagat
     6961 tactataaaa acgaaggtaa agacctgctt ataaaacaag taagttcatc tgttctttgg
     7021 gaagattcta tagaaagact tttaaatgat ggatatgata cttttataga aatgggacct
     7081 ggaaaaactt taaaagcatt tattaagaaa atagcttcca ataaaaaagc aaatgtcaat
     7141 atttataata tagatggtat agattctctt aatgaatttg tacaaaatta tagaaatgga
     7201 gagatataat gataaatctt acaggacaag tagcagttgt tactggtggt tctaggggta
     7261 taggaaaaga aatagcaaaa aaactagcat cttttggagc tgatgtagta atcaattata
     7321 cttctaaaga agatgaagca ctaaaaacta aaaatgaaat agaaagtatg ggggtaaagt
     7381 gtacctctat aaaatgtgat gtgtctaaat ttgatgaagt gaatcaaatg atagattctg
     7441 ttgtaagcga atttggaaaa attgatatat tggttaataa tgcaggcata actaaagatg
     7501 gtctgcttat gagaatgaaa gaagaagatt ttgatagagt tatagatata aacttaaaag
     7561 gtgtctttaa ttgtacaaaa gcagttacta aacctatgat gaaaaagaag tatggaagaa
     7621 taataaatat gacttcagta gttggaatta tgggtaatgc agggcaaact aattattgtg
     7681 catcaaaagc aggtgtaatt ggatttacaa aagcttctgc aagagagtta gcatcaagaa
     7741 acataaatat aaatgcagta gcacctggat ttatagaaac agatatgact aaagtactaa
     7801 gtgatgatgt aaaagaatca acactagcaa acataccaaa gaaatcttat ggtaaaccag
     7861 aagatgtagc caatgccgta gcatttttag ttagtgacat gtcaagttat ataacaggac
     7921 aagtaataaa tgtagatggt ggaatggtaa tgcaataata atttaaaaag tagagaaatc
     7981 tattaaaata aaaaatttta ggaggtacac aatgtttaat aaagttgtag aaataataat
     8041 agagcaatta ggagtagaag ataaagaaat aactatggaa acatcattaa tgaaggattt
     8101 agaagcagat tcattagatg cagtagaaat aataatggca cttgaagatg aatttggtat
     8161 agaaatacca gatacagaag cagaaaactt caaatctata ggagatatag ttaagtatat
     8221 agaagctaat aaatagtcga gctttaaaaa agtggaggta tccgatgaat aaaagagtag
     8281 taataacagg acttggatgt gttacgccgt tgggaacagg aaaagaagag ttctggagta
     8341 atataaaatc tggagtatct ggtatagata aaataactaa ttttgatgct agcacatatc
     8401 aaactcagat agcaggagaa gttaagaatt ttcatccaga agaatatata agtaaaaagg
     8461 aattgaagag attagataaa tttgctcaat ttgcaatagt atctgctaaa ttagcagttg
     8521 aagatgcaaa tcttgattta gataaagttg atagagaacg ttttggtgtt ataataggtt
     8581 ctggaatagg tggagttgaa gctatagaaa ctcaacataa aattcttttg gaaaaaggaa
     8641 ataaaagagt aagttcactt tttgtaccta tgatgatagg aaatatggca gctggtcaag
     8701 tttcaatatt tttaggagca aaaggaccta acactaatgt atgtacagct tgtgcatcag
     8761 gaactcattc aataggtgat gcttttaagg taattcaaag aggtgatgca gaccttatgg
     8821 tagcaggggg ttctgaagct gctgtaacag gtcttgcttt tgctggattc tgtaacatga
     8881 aggctatgtc aactagaaat gatgacccta aaactgcatc aagaccattt gataaagaca
     8941 gagatggttt tgtaatggga gaaggagcag gtattgttat cttagaagac ttagaacatg
     9001 ctttagcaag aggtgctaaa atatatgcag aagtagttgg atatggttta actgctgatg
     9061 cataccatat gacaactcca gctgaaaatg gagagggagc agctaggtct atgaatatgg
     9121 ctttgaaaga tggaaatgtt ccattagaag aagtagatta tataaatgct catggaactt
     9181 caacttatta caatgattta tatgaaacta tggctataaa aactgtattt ggagaaaagg
     9241 catatgactt atgtgtgtca tcaacaaaat ctatgactgg tcacttatta ggagcatcag
     9301 gtgctataga ggctgttgtt tgtgctatga gtatagaaga tagttttgtg cctccaacta
     9361 taaacataca agaagttggt gaagatttgg atttagatta tgttccaaat caaggtaaag
     9421 aaaaaaatat tagatatgca ctatcaaatt ctttaggatt tggtgggcat aatgctacaa
     9481 tagtactaaa aaaatatgta taaataaata ttaaatataa aactaaaaaa caagcacttg
     9541 ttttaactgt ataaatttat attagcttaa atttaaagtc tcctaaatta ttttaggaga
     9601 tttttttatt aagatttaag tctaggatat gttgtaaatc attttgatat attgtattat
     9661 taattattaa gaggttattt atatatgcaa gttttcattc tacaatatac aaaaggagga
     9721 ctaaaatttt gaattttaga ctaccaaaga aaaggttacc caaaaagata atttttatat
     9781 gtataatact tattagtatt attttgttta taaagtatga ccaaaatgga ttgaaagaaa
     9841 gagaaattat aaataaggga aaatatatgt ctgaaagcct tgtggcagat aaggagtatg
     9901 atgaagcaaa aaaagtggtt aagacttctt ttgaatctat tccagaaaaa aaatacaata
     9961 aagtatataa tgaagtttgg gatatgttaa agactatttc atatgttcca gatggaacga
    10021 agatagtcat tgattcttta gaaaagatga gagaatcaga tgtgaaatta tctgatgaat
    10081 gtagatttaa tatagaaaaa agattagcat cagtgtatat aatggataat aattattcta
    10141 aggcagtaga tttaactgta aagtctataa agttggctga gaaattgggg aataattatg
    10201 aaaaagcaag actagatgtt gatttggcga gcatattttt aaagataggt ggctatgaaa
    10261 caggagagaa attaataaag gattctttta aaatagatat tgatgaaggt gaaaaaaatg
    10321 gaatggttag attatatgct attataaatc tagcagaaat atatgtagaa gagggcgaat
    10381 atgataaagc tattgaaata agtagcagga taaaagatta taaaaagttt gtaaatacgg
    10441 ataattacaa tgattttgat ataatggcct ctataatgca gtcaaatgcg tatgtgggca
    10501 aaaataatat acaaaaggca aagacttttt tagaaaaagc tgattatctt ataaaatcag
    10561 atagaacagt ttatatatta gataaagata tgtactatta tatggcaatg ggaaacttag
    10621 aatataaaag cgaaaattat aattctgcaa tagataatta taaaaaaagt ttagagatat
    10681 ctactaaaag aaagttaacc caggagaaaa taaaaaattt aaataagata ttaaatatat
    10741 atgaaaaaca aggaaatata gaatctttaa atgagtatca aaagatgtta ataaatgaat
    10801 ataaagagaa caaaagtata agagattcag agactagttt ctatataatt gataaagtat
    10861 caaacgaaag taagctattt gaaaaaacta aaaaagaaat aaaatattat aaaatattat
    10921 ttacagtaat tttaattgct atattagggt ctactttttt atacaaccga ttgaagtatt
    10981 ttaaagcaca aaatttacat gatggtctta caaatgttta taatagaaaa agttttgata
    11041 ttatgtatga aaagtacaga gagaaagatg ataattttgc acttgtgatg atagatattg
    11101 ataatttcaa gctcataaat gataattatg gacataaatt tggtgacact gttataaagg
    11161 gaataacaaa taccatttgt gttatgttag aacaagatga taaagtcttt aggtacggag
    11221 gagaagaatt ttctgtatta ataagaaata aatctggtga tgaagtagca gatataattg
    11281 acagtataag ggttgcaatt gcaaataaaa agtggaatga tgatgtgact gtgactataa
    11341 gtgcaggtgt agctcatgtt tcagatagca aagatgtact agaagaagct gataaaaatt
    11401 tatataaagc aaaacaactt ggtagaaata aagtagtata taagtaatta tatactatat
    11461 aaataagagg tataaatatg aaacaatcaa tagctatagt aactgataaa ataactaaac
    11521 tatcatcttt cttagaagaa aatatacgtt tggttttagg taattatatt gatataaacc
    11581 actattatct ggaagtttta aaagagaatg ataaaataca aggtgatttt gtactagtaa
    11641 tgaatgatga tagattaaac agtatgagaa agcatttagt acaagatagt aagattatag
    11701 tgataaggag aacacttaaa gaaaatgaaa tatatggatt attttcaata ccaaatggaa
    11761 ctgaagtatt ggttgtaaat gatacaaaag aaactacctt agaaacgata agcttatttt
    11821 acaaaatagg agtaaaaaat ttaaagttta ctccatatat tgaaggaaaa atttataaaa
    11881 atatagacat agctataaca cctggagtaa agggaaaagt accaagttat ataaataaag
    11941 taatcgacct tggaaataga tatattgata tatctacctt tatagaaata ataaatggtc
    12001 ttagaataga tgttaaagaa atacgtaaaa atttaatggc atattctgag agtttaataa
    12061 gtttagataa tggagttaaa gataattata ggcaactgtt tttaaaaata gaagaacaag
    12121 atgttatatt gaatctatca aaagatggaa taatatttac ttcagcagat ggtataataa
    12181 acacatttaa taaagaagct ttaaaaattt taggtataaa tgaaaatcca caaggcaaaa
    12241 acatagaaga tatcatttct gaagatttaa atattttact tgaagacaaa gaaataattg
    12301 atgaagtggt atttacaaat aaaaaatata taaatgtaaa taaaaaaagt attttttcta
    12361 tggggaataa agctgggata tattataact tacaagaaat aacgtatata aaaaaattag
    12421 aacaaaatct tactaataaa ttaagagaac aaggtcagat agcaagatat acatttaaag
    12481 atataaaaac taaaaataaa aatatggtaa agtgtgtaga attggctaaa aaaatatcta
    12541 aatcagacct ttctgtatta ataataggag aaagtggtac tggtaaagaa ttattatcac
    12601 aatcaattca taatgcttcc aatagaagta atcaaccgtt tatagcagtt aattgtgcag
    12661 cagttccaga tagtctatta gaaagtcaac tgtttggata tgaaaaaggc tcttttacag
    12721 gagctttaag agaaggaaaa aagggtctat ttgaacttgc taataatgga actatatttc
    12781 tggatgaaat tggagatatg cctccattgc tacagacaaa gttactaagg gtattacaag
    12841 aaaagcaggt tatgcctata ggttcccata atgttataaa catagatgtt agggtcatag
    12901 cagcaacaaa caaaaactta ctaaagatga ttagagaagg aaaatttaga gaggacctgt
    12961 attatagact aaatgtattg ccaatagatg taccatcatt gaggaataga aaagaagata
    13021 taataacact tatgaatttc tttttgaaaa acaatataag actttcgcca gaagttataa
    13081 ctattttaga aaaatataat tggccaggaa atataagaga gttacaaaat gttgcttctt
    13141 atgtaagtct aatgtgtgat agtatggttt ttagagatga cttaccacca tatataaggg
    13201 tagaatgtgc taacaattat gaagatggat ttggttatac aagaaaagaa tttgaggaaa
    13261 tactgaggat tctatatgaa agaagagagt catcctctgg aattggaaga gggtttataa
    13321 tcgaaaagct tatacaggaa ggtattgaga tttctgaaag caaagttaga aaggtgctat
    13381 cttatttaag tgaatgtgga tacatatcat ctaaatctgg tagaggagga agtcaaataa
    13441 cctcagaggg gataaaactt tataataata taaattaagc taagtatttg atattgaaat
    13501 cacatatttt gaatttagat atttaaataa taataaactt ttatatttat agagattaat
    13561 ttatattatg tcagaaagaa tattgtaatt tataattaaa tattaatagg tttttaaaat
    13621 aggattagat aggtaatagg ttaagttaga ataacccatt acctattttt atttgtaaga
    13681 aaagtgtaca tagaattaga agtaaaaaat acaactaata aaactattga aaatactaga
    13741 taaataataa ataaaaataa ttatagattt tggcatacat attgctaatt atagagataa
    13801 gacgacaaaa taattgggag gtttaatgat gaaatacaaa acaacaggga cttgtgctac
    13861 agaaattgaa tttgaagtaa aagaaaataa agttacaaat gtaaacttta taggtggatg
    13921 tgatggaaat ttaaaagggc taaaagtatt agttgaaggc atgaatatag aagatgtaat
    13981 acaaaagtta aaaggaatag agtgtaaaac aaagccaaca tcttgcccag accaactgtc
    14041 tctagcattg gaaaattata tgaatataaa gtaatacata aaacaatcga ttagttagga
    14101 gtttaattat gaaaccaata atagggattt taggaaattt aataataatg gaaaatggta
    14161 tgtttccagg tcttgaaagg tcatatgtaa ataatgatta tataaatgca gtgctaaaag
    14221 gtggcggtag tccagtaata attcctgtaa atacagataa agaagttata aaaaaacaga
    14281 ttgaaatggt tgatggagtc ttaatatctg ggggatggga tatcaatcct caactgtatg
    14341 gagaagaaac aagagaagaa acgacattta tatatccaga agtggatgaa tttgatttaa
    14401 ttgcaataag tatagcatta gaacttaaaa agcctatatt aggtgtatgt aggggactac
    14461 aaattttaaa tgtaagttta ggaggaactt tatatcaaga taataatctt atagaaggaa
    14521 gttatataaa acatacacaa tcttctaaaa gacatgtagc tactcataaa gttgatgtta
    14581 aagaaggaag tattttagag ggaattttag gaaaacaatt acttacaaat agttatcatc
    14641 atcaaagtgt caatcagctt ggaaaaggat taaaagccat agcatactca aaagatggta
    14701 taatagaagc tattgagaaa gaggatgaaa attttgtagt aggagtacag tggcatccag
    14761 aaatgatggt agattactgt gataaaatgg aaaaactatt taaatatttt ataaatattt
    14821 gttcgaattt ataatatacc ttggggggat tgaacatgaa cgaaaagaac aaaatgggat
    14881 taataagtat tatactttta ggtattaatg cagtagtagg agctggagtt tttctattac
    14941 caggagatgc aatgaaatca tttggtgtag caagtatatt tgtatatata tttgatatgt
    15001 tgttagtttt atctatggca ttctgttttg ctgaggttgc aggtaaattc aataaaaatg
    15061 gtgctgccta tgtatataca aaagaagctt ttggagattt ttgtggtttt gaagtaggtc
    15121 ttatgaaatg ggtaatagga tgtatttctt ggggagcttt aatagtaggt tttcctacat
    15181 cattatcagc agtatgggct ccagcaggtg aaccacatat acaaaaaatt ataattgtag
    15241 ctatgatagt tgggcttaca attataaact tattaggtgt atctctatca aaaattgtac
    15301 aaaatgttat aactgtaggt aaactaattc cattaatact atttatagga ataggtatat
    15361 tttttataaa aggagttaat tttacttctt caacaatggt acctccagga gctggagcaa
    15421 cagagtttgg agcagcagca cttttaatgt tttattcatt tacaggattt gaatctatag
    15481 cagttgcagc agaagatatg gaaaatccac aaaaaaatat accaatagca attataagtg
    15541 taatagtaat tgcatcaata atatatatat taaatcaagt tgtatgtgtt ggtatactag
    15601 gagattcgtt atctagtaca tctacaccag tggcagatgc tgcaagaata tgctttggaa
    15661 atatgggagc tggattggtt acctttggaa cattggtttc tgttggtgga atttgtatgt
    15721 gtggtgcttt tgtaaatcca agaagttgtg tagctttagc tgatgataaa atgttaccga
    15781 gaatatttgc aagaaaagat aaaaaaggta caccatatgt agcgataata gctactatgt
    15841 taatcactat accaatagct ctatctggaa gttttgctga attagcagca ataagtgcag
    15901 ttgctagatt catacaatac ataccaacat ctttatccgt attagtgttt agaaagaaaa
    15961 gaccagaatt agtaggtact tttaaaactc cttttggagc agtgattcct ctaattgctg
    16021 tatgtgttgg aacatggttg ttattccaag catctatgca tcaattaatt atgggattag
    16081 gagctttggc aattggagta ccattatact ttataatgaa gtcttataat agaaaaatct
    16141 atggtgaaaa tttaaagaaa atagtttaat tatgttataa caatttattg agttaaaatt
    16201 agacattggc agaaaattaa atacaaataa gtatctacaa ggctatatta aaatattatt
    16261 aattttttat tttaatatag ccttatattg ttatcaataa atgaaaaata ttgtaacaac
    16321 agaagaacaa tagtattatg tttatagaca aaaaacttat taggaggtaa atttatgcca
    16381 acaataacat taaaaaatgg tgtagacgta cttattagag aaggtgtaag agaagatgct
    16441 caaagcatta tagattttta taatgaagtg ggtggagaaa ctcattttct gtcatttgga
    16501 aaggatgaat ataaaatatc tttggaggaa caagaaaatg ctatagaatc agcaaaagca
    16561 tctgataatt ctgttaaact gattgcattt atagatggtg aaatagttgg gattgcaacg
    16621 attgattcta atcaaaaagc aaaaggaaag catgttggag tattaggaat tgttgtaaaa
    16681 gaaaaatatt ggggaattgg attgggtaaa aggcttatgt tagaccttat agaatggtgt
    16741 aaatcaaatg gaataaccaa gaagataact cttgtcacta atgaagaaaa ttataatgct
    16801 ataggattat acaaaaaagt tggatttgaa gtagaaagca tactaaagaa agaatgttat
    16861 tataatggtg tttatactga tttaatagga atgtcacttt tattgggaat ataattagtg
    16921 tacattttat ctcgaaaaaa gtatattaag tatggtataa ttaaaaaaga atataactta
    16981 atataatttt ggaggacgaa ttatgaaaaa tctgtgtaaa atatcagatg attatttaaa
    17041 cagcaagctt aagtatttaa agttattatc aaaacaatat ccaagtatat caaaagcaag
    17101 tacagaaata ataaatttag aggctatatt aaatcttcca aagggaacag agcattttat
    17161 aacagatgta catggtgaat atgaaccatt tgtacatgta ttaaaaaatg gttctggtgt
    17221 aataaagaga aaaatagaag aattgttttc aaatacaata agagacagcg aaaaaaaaat
    17281 gttagcaact cttgtatatt atcctgaaca aaagttagac ctaataatta agcaagagga
    17341 aaatatagat gatttttata gaataaatat ttatagactt atagaacttt gtaaatatgc
    17401 ttctagcaaa tatactaggt ctaaagttag aaaactgtta ccagaaaatt ttaaatacat
    17461 aatagaagaa cttttgcatg agcatgttaa aagtgaacat aaagaagagt attataaaag
    17521 tatagttgaa acaatagttg acataggaat agctaaggag tttataattg ctatttctac
    17581 agttatacaa aaattggttg tagatagact tcatgtaata ggagatattt atgatagagg
    17641 tccaagacca gatataattg tcgataagct tattgaacat cattgtgtag atattcaatg
    17701 gggaaatcat gatatattgt ggatgggtgc agcctcaggt gaaaaaactt gtatagcaaa
    17761 tgcactgagg atatcagcta gatatgcgaa tttagacatt gtagaagaca tatatggaat
    17821 aaatctattg cctttagcca cttttgctat agaaatgtat aaagatgacc cttgtaaaga
    17881 atttattcca aaggttaatg accaaagtgt aacaacaaca gaaaagtctt taatggcaaa
    17941 aatgcacaaa gcaataagta taattcaatt taagcttgaa ggtgaggtta tcagacgaag
    18001 acctgaattt gaaatggaac atagactctt gcttaatatg ataaactatg atgaaggtac
    18061 gattaattta aaaggtaaaa catataaatt aaaagatact tatttaccta caatagacaa
    18121 aaaagaccca tataaattaa ctatggaaga aagaaatgtt attgataaat tagtatcttc
    18181 atttagaggt agtgaaaaac tacaaaaaca tgtttcattt ttgttttcta aaggaagtat
    18241 atatttaaag gctaactcaa atttactgat tcatggatgt gtaccgttaa atgaagatgg
    18301 aagctttatg tctatgaata taatgggaaa agagtataaa ggtaaggctc ttatggataa
    18361 gatggagtct ctagcaagag aaggattttt ctttaaagat aaggcagaag aaaaactgta
    18421 tggcatggat attatgtggt atttatggac tgggaaatgt tcatcattat ttggtaaaga
    18481 tgatatgact acatttgaaa gatactttat agctgaaaaa gagactcata aagaaaataa
    18541 gaacccatat tttaaactta gagaaaatga gatggcttgt aaaagattat ttgaagaatt
    18601 tgatttagaa cttgatgaat ctcatataat aaatggtcat gttcctgtgg agagtaaaaa
    18661 tggagagagc ccaataaaag ctaatggtaa aattctcgtt atagatggtg gtttttctag
    18721 ggcttaccaa aaaactactg gtatagctgg atacactttg atatacaatt ctagaacttt
    18781 gcaattagta tcgcatgaac catttaattc tgctgaagaa gccattgcaa atgaaagtga
    18841 tatcttatcg acaactgttg tagtagagca taaggcaaag agaaaaatgg tgagagatac
    18901 tgatgaagga ataaagatac aagaggaaat agaagattta aaactacttt taatggctta
    18961 taagaaaggg ctaataaaag aaatgtagat gttatagagg cacttcatga ttgaagtgtc
    19021 tttttgttaa tacttattaa atatattata aagattaata atagtagttt atattatact
    19081 tactaagtga atccaagata aatgggttca ctttttttat ttataaacat tattaaaaaa
    19141 atatagatgt tttggttata ttccttgtcc tttataaata gaattatata aacaaaggag
    19201 gaggacaaga gatgaataaa ctttctgatg aaataataaa ctctctttct acaactataa
    19261 gagaaaaggt agaaaaagtc tcaaacaata atctgaacat agaagaaatt aggttacgct
    19321 cacaaaaacc attgatacta aatgcaaact ctaaagatta tttttacaat caaaaaacta
    19381 tgacacttga tttaaatcaa caaaactcat atgtagtaac aagagaagat gtagagcaaa
    19441 cttttcaaat aatatgtaaa tattcaatac attcatttat ggatgacata aaaaaaggat
    19501 tcataacttt gagaggaggt catagagtag ggttagttgg aaaagcaata gtagaagatg
    19561 gacaagtcaa aaatataaag catatatcat ctttaaatat aagggtatca agggaaatta
    19621 ttggatgctc ggataagatt ttaagtcata tcataaaggg aaaaaatcag attaataata
    19681 ctttgataat atcaccacct caatgtggaa aaacaacttt aataagagat atagtaagaa
    19741 atttaagtaa tggtaatgaa gattatggat ttaaaggttt aaaagtggct ttagtagatg
    19801 agcgtaatga gatagcagga gcttatctag gtgttccaca aatggatgtg ggaataagga
    19861 ctgatataat agaaacttgc ccaaaagact tgggtattac aatgctttta aggtctatgt
    19921 caccaaatgt tattgtgaca gatgaaattg gaagtgaaaa agaaataaag gcattataca
    19981 cagcattaaa tggaggtata ggattaataa ctactgtgca tggagattca atagaggata
    20041 tacaaaatag aaaagaatta aatagacttc tggataaaga gttatttaaa aaggttataa
    20101 ttctttctgc aaaaagagga gcaggaacaa ttgaaaaaat ttatgattta gaagaaaaga
    20161 gatggtattt tgcaaattaa aataattatt atagctttct tgataggaag tagttatttg
    20221 ataggtgaac aaatatacaa aacttatact cgtagacata aacaattaaa cgatttaata
    20281 agagttttag aaattttgag gatggattta tcttttggac tttatacatt agaagaaatc
    20341 tttaatagga taggtggaaa taaagagttt tgtttttgga aatttttcta tcaaatatca
    20401 gaaggacttc acaatgaaca aagtaaaact ttggaaataa taatatcaga aaatattgat
    20461 gtcttaagta aagaaactta tctaggcaat aaagaaattg aggaactgaa aaatctaata
    20521 cttactttag ggaaaagcga tatagagtca caacaaagaa tgatagattt atctatagaa
    20581 aatttgaaaa aacaaaccta tgagacaaag gaagatataa acaaaaaagg cgtattgtat
    20641 aaaaaattag tgacattcat aggtataggt atatgtatta tattgattta atatggggag
    20701 gtttattatg gaaatatcat tgatattaaa ggttgcaggt gtcggtattc taatatcagt
    20761 attgaatatg atattggaaa aaacagatag aaaagattgg gcaggtctta ctacattagc
    20821 aggtgtaata atcgtattgg gtatggtaat aacagaaata agtgacttgt ttaatactgt
    20881 aagaacaatg tttcaacttt actaaagagg agggagtaat ttggaaataa tgcaattaat
    20941 aggaattgca atcatttcaa ctacactctg tttagtaatt aaaaaagata gaccagagat
    21001 agcaaatttc atagctataa taactggagt aataatacta ttgtcagtta tgtttaagct
    21061 aaattttata gtagatagta tacaagattt ggctaacaag gctaacatcc caactatgta
    21121 tatatcatta ataataaaat taattgggat agcatactta atggaatttg cgatacaact
    21181 ttgtaaagat tgtggggaag gaaacattgc ttcaaaacta gaatttggag gtaaaataat
    21241 agttatgtca atgtctttcc ctatactttt gtccattgta gaaatggtgg tgaatataat
    21301 tccatagatg tgtatcttgg aatgaatata agtatattag agagctttcg ttgtattgag
    21361 gtttatagag tgaagagagg catggttgct tatgaaaaaa agatttttac caatgattat
    21421 aggtttttta tttactttct tttttgtaaa tatctttgct attatgatat ttgctaatga
    21481 agtaccaagt agtgaagata aagaatatgg tgaaacaaaa aatagcatag ataagtatat
    21541 agatggtcaa ttagacaagc tagatataaa tgagattcaa gactatataa ataaagaaat
    21601 agttattaat gatgttaatt taaaatcatt tgtaaaagat ttaattagtg gagaaaaaaa
    21661 tatcttagat ttattcaata aagatggatt gaagatattg atgtttgatg aatttaaagc
    21721 aagtttaaag gtagtagcag taattttggt actggctctg ttatcatcta ttttaaagag
    21781 tctggaaaac tctttttcat caggtgcagt aagtcaaata gcaacatata taatatttat
    21841 cacaatggta tcacttacac ttattggttt taaagatgta ttacagattt gctatgatgc
    21901 aatagaccat actgtaggtc ttatgcaagt tataatgcca atattaataa catttttact
    21961 tttaattgga ttcccaataa cgtcgactac tttgaatcct atcttcatag gaggagtaac
    22021 atttataaat gtatttttta aaaattttct atttgtatct attactgttg catttggaat
    22081 tttaataata aacaatttat caaaaaatat aaggctaaag agatttttct cctttgtaaa
    22141 acaaataaat tatgtttcta ttggagctat gtttactgtt tacttaggtc ttgtatccat
    22201 acaaggattg tatgtaacca gttttgataa attcagtgta aagactgcta aatttgctat
    22261 aggtaatttt attcctgttg taggtggatt tgtatctgac tctgtggata ttttattatc
    22321 ttcatctcag cttataaaaa atatatttgg aggaatagga cttatcttac ttgttggaat
    22381 ttgcttactt ccagtaataa aaattttatc agtaatagta gtgtacaaat tagcagcaat
    22441 aattgtagag cctgttggag aggatggaat atctaatttt ttaaatgaag tggcaaattt
    22501 aatgataata atgctagcat cagtaattgc tataacagta atgttctttg taactgtagc
    22561 tatcttgacc tcgataagtg tcgtaagtca agggtaattt atatatcagt gaaaaataat
    22621 tacatttaat ctaatgtttt tagagaggag gatgctatgt tagagggcat aaaggcatgg
    22681 atagttagtg ttttgatagg agcatttata gtaaatatag tagatatgat tttaccaagt
    22741 tctaagataa aaccttatgt caacctagtt ttaaacttta tgtttgtatt tattgtaata
    22801 actccagtag taggattttt ttcaaaagat atgagtttag aagatagaat attaaaatct
    22861 atgggaaact acaacaagca gtatgtagat agtacaaatg ctttggcaaa agagactgga
    22921 aataatagtc tatccaaggg atatgaggat gggttaaaag aagtacttaa attaaaactt
    22981 gatgaatatg gttatgattt agaagatata gagcttaatg gggcaaatat aaataatata
    23041 aaaataaaag aaaagaataa tagtgcaaaa agtaataaca gttccaatga agaaaataaa
    23101 aataatagta ctaaaagaga ggaagaaaac ataaactcta atgacaaaga aaattctaaa
    23161 caagtcttca aaaaaggtac agagtatggg ttgaacctaa atgaagaaaa attaaaaaac
    23221 gacttaataa aggtgctgga tgtttctata gaagatatac aaattgataa ataggagttg
    23281 ggagaatgtt gaaaaactta aatgacaaag ataagagaaa ggtatattca ctaataacta
    23341 tagcaggaat atgtgtggtt tcattagtat tattatcttg ttttcctagt agcaaaagcg
    23401 ataaacaagt tggaaaaaca gagactaata aaaatgctga aaagcaagtc actaaagaac
    23461 aagaaaaaga tgatttagag tcaaaattaa cagcaatact atctaaaatt gatggtgcag
    23521 gagacgttga tgtaatggtt acatttgaat caagtgaaga aatacaacct gcttttaatt
    23581 caaataatac aacagaaaca acagaggaaa aagatgcaca aggtggagaa agaacagtta
    23641 cgacttctag tgaaaataaa acaatgataa cttcaaattc aagtgaccct gtagttataa
    23701 aaactacaga gccaaagata aagggagtga tagtggtagc aagtggagca agtgacccaa
    23761 gtgttaaaga gacactttat agtgcagtac aaacatcatt acaagtagct ggtcatcaag
    23821 tagaaatata ttctaaataa atacatataa ccggggggat aaatgaatga agtttaatta
    23881 taagggaaga ggatttgtaa taataacttt aactgcaatg ttagtggtag taggaacagt
    23941 gaattatcaa ctaagtaaga aatctttatt agaaacatca aaagagttta aggcatatga
    24001 agaagcacag ttgcaaaaaa atactgatga gagtgatagt agtaagacag aggattctag
    24061 taatgtagat aaacaagatg gtaaggaaag tgctgatatt gatatagttg atagcaaagc
    24121 tagtaaagta aaagaaaagg caactgagac aagtaaggaa ataaaagctc aattatcatc
    24181 agagaaaaat atgaaaaagg catcttatat tttagatatg aaaatgaata gagaaaaaca
    24241 aagaaatgag ttagttcaag atttaaatga aatgataaat aatccatcta caacagaaga
    24301 atctagaaaa gaagcttcta atatgaaatt aaatatagtt aaaattcaag aaaaagaact
    24361 tcaaatagaa aaccttttga gtacaaaagg gtatgaagaa gcgttagttt atataagcga
    24421 taacaaagtt aatgtagttg taaatgaagc taaattagaa aagaaagatg cagcaaaaat
    24481 atttgattta gttgcagaac aagccaatgt gaagtatgaa aatattaaac ttacaaataa
    24541 taatagtaat aagtaaagta taaacctcag aattaactga ggttattttc ttgcaaagta
    24601 gacttgtatt tggtattatt atacttataa aaatagttcc ttaaaatcag gaggtaagtt
    24661 ttaatatgga agataataaa tttggacaag taaaaatatc taatgatgta atagctacaa
    24721 tagctggttt agcagcatta gaagttgaag gcatagaaac tacagcaaca ttaacagata
    24781 agttgttaaa aaataatgga gtaaaaatac aaatcgaaga agaggatgtt aatttagatg
    24841 taatggttac gataaagtat ggaatgtcaa taccagatac agcttttaaa gttcaagaaa
    24901 atgtaaaaaa tactgttgag acaatgacag gactgaaggt ttctcaagta aatatacaca
    24961 ttcaaggaat cagctttaag aaggataaag ttgataaaga agaagcaaaa gcaactaaga
    25021 aaaattaata ttagccctct gaaaagtcag agggtttttt gctggtaatt gattttatat
    25081 ggataattaa acttaaagga gaattttgat tgatgaaaaa agatagggca caaaagagta
    25141 caacaagaga atatataatg aaacttatat accaaataaa tattaataaa gaagattttg
    25201 aaactttaga agataaagta gataattttt taaaagataa ttcagaacat attataaata
    25261 gatataaaga acttgcactt caatactcaa aaaatacaaa tttaaagtta gaagatactg
    25321 aaattgaaga tgttatagac aaaaaatata taaatacagt atgcaaagca ttgaaagaaa
    25381 atcatgacaa aatagatgag ttaataaata agcatgctaa aaactggaca gtagatagaa
    25441 tgccaaaggt agatgtttct atacttagat tgtctgtgtg tgaaatactt tatttagaca
    25501 ctcctaataa agtatcaata aatgaagcag tagaacttgc aaaaatatat tgtgatgata
    25561 agtctcctaa atttataaat ggtatattgg gaagtgttgt tgatgaaatt gggaaataat
    25621 ataataattg gaattgatac tagctgctat actacttcta tagcagctat ctctttagat
    25681 aagaaagtta tattcaatga aaaaataatg ttagaagtaa gggataattc aaaaggttta
    25741 aggcaaagtg aagctgtatt tcaacatatc aataatttag ggattcttag tgataggata
    25801 aaatctttta aagataagtt taatgtagaa ggagtttgct catcaaaaaa accgagacct
    25861 gttgaaaact catatatgcc tgtattcaat gtaggtcata attttggaaa attattgtct
    25921 agtatatatg gttgtaggtt ttatgagact actcatcaag agaatcatat tgaagcaagt
    25981 ttattaaata gtaaattaaa aaataataat aaatttattt ctgttcatat gtctggtggt
    26041 actacagaga tacttttaac aagcaaacaa gatagtcatc acaatgtatg tgatactaat
    26101 ttaggtaaaa ttgccaaaat aagtattaaa aaagatgata aaagtaagtt atacaataat
    26161 tttggatata atatagatat aattggagga agtaaagata ttagctttgg tcaacttata
    26221 gatagagtag gaattaagct tggatataaa tttccttcag gaaagtattt ggatgaaaat
    26281 gctttaaatt gtaatcttaa aatagaaagt ggtctgaaaa cttctgtaag agatgggtat
    26341 atgaatttat caggattaga aaatcaggta aataagatta taaatgataa tggagataat
    26401 actaatcaaa aagaatatat atctaaattg gtattagatt cagtagttag aaatatgttt
    26461 aaatctttag tgtatttatg tgaaacttat aatgtaaatg aagtagtatt tgctggtgga
    26521 gtttctgcaa gtaagtatat tcttagagaa ttaagcatga agttaagaaa aaagcatata
    26581 gaagcttatt ttacagaacc acaatattca actgataatg ctgtcgggtg tgctataata
    26641 ggattgaata actttttagg agaaagagta tgaaactaag agctttagat ataagtgaag
    26701 caaactcata tattaaaaga attttaataa acgacccaat actttctaat cttaaagtta
    26761 aaggagaaat ttctaatttt aaggttcata gtagtgggaa tgtatattta tcacttaaag
    26821 atgaaacatc aaagttaaac tgtgtaattt ttaaaagtaa ttttaatcgc aatttaaaat
    26881 tagataatgg tgtaaaaatt atagctaatg gatatatatc agtctatgaa agagatggtg
    26941 cgtatcaatt atacattaat gaaattgaaa tagagggaat aggaaattta cacatagagt
    27001 ttaatagatt aaaggaaaaa cttaataaag aaggattatt tgaccctaaa tacaagatac
    27061 ctatacctaa aatgccaaac tcaattggcg ttataacatc tccaacaggt gctgttataa
    27121 gagatataat aaatgtaata aaaagaagat atccgaaagt taatataaag ctttatccag
    27181 taacggttca aggagataaa tcagctgaag aaatctgtga agcaattaga tttttcaatc
    27241 atatgaagaa tgttgataca cttatagttg gtagaggtgg gggttcgata gaagaacttt
    27301 ggtcttttaa tgatgaaatg gtagcaagag aggtttttaa ttctcaaatt ccgataatat
    27361 cagcagttgg gcatgaaacg gattttacta tttgtgactt tgtgtctgat atgagagccc
    27421 caacgccatc agcagcagct gagattgcta ctccatcatt ggatgatata aactataaac
    27481 ttggaaacat aaaaagtagg atgagtaagt ctcttacaaa tcaaatagag ctagaccaat
    27541 ataggttaga aacagtattt aataagataa ataactattt agattcgtac acaataaaag
    27601 ataaagttat acaattagac aaaatatatg ataaaataat ttttggaata gaaaataatt
    27661 taaaattaga agatgaaaaa ttagtaaaaa ttggagcatt actccataat ttaagtccat
    27721 tagctactat ggatagaggt tatagtataa ctcaaaaaaa tggaaaagta ataaatagta
    27781 taaaaggatt aaaaataaag gatagtatag atatagtatt aaaagatgga aatttagaat
    27841 gtatgataga taaaattgaa aataaagagg gatagtatga atttaaccta cgaagaagct
    27901 tataaaagat tagaaagtat tttaagtgaa ttagaatcta aaaatgctag cttggatgaa
    27961 tctttaagcc tatatgaaga aggtataagc ctttataaac attgtaataa gcttttagat
    28021 gatgctaaat tgaaaataag taaatttaat caattgggaa tagaagaaga ctttaaaata
    28081 gaggaggaat aaaattggaa tttaaacaat gtctaaaaga aaaagcaagt tttgtagaaa
    28141 aagtacttaa agaatatatg cctaaagaag aagggtatca aaaaactgtt attgaagcta
    28201 tgaactatag cttaagtgct ggaggtaaaa gattaagacc aatacttaca ttggaggctt
    28261 gtaaaatagt tggaggtaat gaagatgaag ctattccttt tgctattgca attgaaatga
    28321 tacatacata ttcactaata catgatgatt tgccagctct tgacaatgat gatttaagaa
    28381 ggggaagacc aacaaatcat aaagtatatg gagaagctat ggggatttta gcaggagatg
    28441 ctttgttaaa ctatgctttt gaagtaatgc ttgcaggctc aatcaataaa gaaaatccag
    28501 aaaagtatct aaaagctata aatgaaattg ccaaaggtgc tggtatatat ggaatgatag
    28561 gtggtcaagt agtagatgta gaaagcgaaa ataaacaaat tggaaaagaa aaattagatt
    28621 atatacatat gaataaaact gctgcaatga tggtaggctg tatgagagca ggagctacta
    28681 taggtggagc aaattctgaa caaatggaag aaataactaa atatgcaaaa aatatcggat
    28741 tatcattcca gatagtagat gatatactag acatagtagg agatgaagct aagttaggta
    28801 aaaaggttgg aagtgatata gaaaatcata agtcaacata cccatctctt ttaggtttag
    28861 ataaatctaa agaaattgca cataatttga ttgatgaagc aaagaaaagt atagaaaaat
    28921 tatctgatga tgtagatttt ttaaagggat tggctgaata tataatagat agagaatact
    28981 aaaatataca gctaaaatcg aggagggaaa aatggatttt ttttcggaga tttttaacaa
    29041 tggggctttg ggaataagtc tgattgcttg tttcttagca caatttataa aaatatttac
    29101 tggtaaggaa aaaagaattg agttatcaag aatacttatt tcaggaggta tgcctagttc
    29161 ccatagttct tttgttacaa gtttagctac agtggtaggt attgaaaaag ggtttaattc
    29221 tactgatttt gctataatta ccgtgcttgc cttaattata atgtatgatg cagcaggtgt
    29281 tagacgggct gttggtaaac aagctactat attaaatcaa atggtggcag atatacagca
    29341 tggaaagcat atagagcaga agaaattaaa agaattaata ggtcatacac cactagaagt
    29401 ttggtttgga gctttacttg gaatagtaac agctttaata ttgatgtaaa ttgaaaattt
    29461 acagaataaa ggtgaggata atatgtataa atatttagat aaagtaaatt ctccaaagga
    29521 tataaaaaat atgagtatag aagaaatgga tttacttgca aaggatataa gaaagttctt
    29581 agtaaaatct gtttcaaaga caggaggaca cttagcttct aatctaggag tggttgagtt
    29641 aacattagca cttcataaag tatttgatag ccctaaagat aagattgtat gggatgtagg
    29701 gcatcaatct tatgttcata aaatagttac tggaagaaaa gattgttttg tatctttgag
    29761 acagtttaat ggactaagtg gttttccaaa ggagaatgaa agtcctcatg atatttttga
    29821 tacaggacat agcagtacat ctatttctat agctacaggt attgcctgtg ctagggatat
    29881 aaaaaaagaa aactatagtg ttatatctgt gataggagat ggttctataa caggaggtat
    29941 ggcacttgaa gctttaaatc aattaggata tatagatacc aatatgatag taatccttaa
    30001 tgataatgag atgtccatag ataaaaatgt tggaggaatg tctaaatatc tgtcaagtat
    30061 tataagaaac tcaacagttg agaaaatgac agatgaagtt gataaaattt taaatgttac
    30121 acaaacaggt gaaattttat ctaagactgc acatagattt aaagataaac taatgtatag
    30181 cttttctcct caggactgtt cattttttga ttcattaggt ataagatatt atggacctat
    30241 agatggccat aatactaaag aactaataga tatattgaga aaagctaaac acaaaaaagg
    30301 gcctgttctt ttacatgtaa ttacgaaaaa aggaaaaggg tacagatttg cagaagaaca
    30361 acctgataaa tatcatggag tatcaaagtt tgatataaag acaggtgtta catctgcaaa
    30421 agttaagtct atgtcaatta gtgttggaga aaaacttgtt gatatggcta atagtaatga
    30481 aaatatagta gcaataacag ctgcaatgcc atctggtaca gggttaaacc tgtttgaaag
    30541 tgcatatcca aaaagatatt atgatgttgg tatagctgaa caacatgcaa caggatttgc
    30601 agcaggtctt gcaaaaaatg gtatgaaacc ttactttgct gtgtactcat catttttgca
    30661 aagggcatat gaccaagtta ttcatgatgt atgcataaca aaaaagccag ttacttttct
    30721 tatagataga gctggattag ttggaaatga tggagaaact catcatggta tgtttgattt
    30781 aagttactta aattctattc caaatattgt agtaatggct ccaaaagaca caagagagat
    30841 ggagcttatg atggatttgt cattaaaatt agattgtcca ctagcaatta gatacccaag
    30901 aggaagtagt tattacctag ataagggaga gtatggagag attgtactgg gtaaatatga
    30961 ggtattagat gacggtcaag atacagtcat actttgtatt ggaagtatgg taaaacatgc
    31021 tttagaggct aaagaaatat tatcaagaga aggaataaat ccgacaatag ttaatgctag
    31081 attcttaaag ccaattgatg aaggtatgtt aaaagcatta ttaaaaaatc ataaaaatgt
    31141 agttactata gaggataata ttgtaactgg aggatttgga agtagaataa ataagtttat
    31201 tatagataat gaatataacg taaatatact taatatagca ataccagaag aatttgtaaa
    31261 acatggcaat atagatgaat tatatgattt tgtaggatta tcgccaaaaa gtattgctga
    31321 taaaataagg aaattagtta ttgagtaaaa atctaatgta gatattgtaa attaaaattt
    31381 atataaaata tagaatttat caattagaat aaatatcaag tgtgttactt caagctactt
    31441 tagttatcat taaagtagct tttaacagaa aggtaattgt atgaaaaaaa gaatagattt
    31501 attattagta gaacaagggt actttgaaag tagagaaaga gccaaaaaag caataatggc
    31561 tggattggtt tttgttgata atcaaaggtg tgataaggct ggtacagaag taaaagaaga
    31621 ttgtagtata gaagtaaaag gaaatccaat accatatgtc agtagaggtg gtttaaagct
    31681 tgaaaaagca atgaaaaact ttgatttgac tattgatgga aaggtatgta tggatatagg
    31741 ggcatccaca ggtggtttta cagattgtat gctcaaaaat ggagcaataa aagtattttc
    31801 tatagatgtt ggttatggtc aacttgcatg gaaattgaga caagatgata gggttgtgtg
    31861 tatggaaaga accaatataa gaaatgtgac aatagaagat acaaagcagt ttgctgattt
    31921 tgcgtcaatt gatgtgtctt ttatatcgtt aaagttagta cttccaaagg caaaggagtt
    31981 agtacgtcat gatggggaag ttgtcgcttt aattaaacct caatttgaag caggaagaga
    32041 aaaagtaggt aaaaaaggag tagttagaga aaaatctaca catatagaag ttataaaaat
    32101 gatttctgat ttctcagtcg aaaatggatt tgagatttta gggttagatt tttctcctat
    32161 taaaggtcct gaaggtaata tagaatatct aattcatttg agaaatggaa atgaaggata
    32221 tgaatttgat ggtgagacat acaataacaa aatagtagaa gttgttgaag cttctcataa
    32281 tttagacaaa taggttaaaa gggggcttag atttgatcct cgaattatat atgaaaaatt
    32341 gtgccttagt tgaagaacta aggttgaata ttgataaaaa cttaaatata cttacaggtg
    32401 aaactggttc aggaaaatct ataataatag atgcacttgg actttgttta ggtgataaat
    32461 atgataggtc ttttttaaga aaaggaacag ataagggact tgttgaggct gtattttttt
    32521 cagacaatag atatcttaaa aaaatattag aagaaaatga tataagtatg gaagatgata
    32581 atttattggt aataactagg ttgatatact cagatggtaa gagtactgct agagtaaatg
    32641 gaaggactgt taaagtgtct cttcttaaag aaattgcatc tacacttata gatatacatg
    32701 gtcaacatca aaatcaagct ttgtttaata aagatactca tttaaaattt ctagaccttt
    32761 ttggagaaaa tgaattggaa gagtttaaaa ttgcttataa aaatgtgtac cataagtata
    32821 gtgaagtaaa aaaagcttta aattgcttga cagaaaataa agatgagatg caaattcaac
    32881 gagaaataga tttattaaga tttcaaataa atgaaattga agctgcaaat ctaaataaga
    32941 atgaatatga agatttatta aaacaaagag aagtttatag aaatagtgaa aagatatata
    33001 ataatctaaa ttcgagttat agcaagttac ataatggtga gtataatgtt attgacctaa
    33061 taggtcttgc atctaaggaa cttaatgaca tatctaaata tgacagtgtt ttaagtgaat
    33121 atagtgatac tgtagaaaga atcatgtatg agttacaaga catatctggt gagataagaa
    33181 attacaaaga taatatagac tttgaacctt atgagctaga gcagattgag cttagaatcg
    33241 acgagattaa taacttaaga agaaaatatg gagacagtat agatgatata tttgagtatt
    33301 atggaaaaat taaagataga ttagatgaaa tattaaacag agatgaaaga gttgaacagt
    33361 taagaagcaa actgatgaat atagaagaag atttaaaaat aaaagccagt aaattgacta
    33421 aagcaagaat agaagtagca actactttag aaaaaatact tcttgatgaa ttaaaaagct
    33481 taaatatgaa aaatgtaatg ttcaaggtta attttgaaaa aggtccattt actttagatg
    33541 gagtagatga tattgaattt atgatatctt ttaacttagg agaagatatt aagcctatat
    33601 ataaagttgc atcaggtggt gagatgtcca gatttatgtt agcgtttaaa accatattgg
    33661 ctgatataga tgatattgat acattagtgt ttgacgagat agatactgga ataagtggga
    33721 tagcagcaca gatagttggt gagaaattga gtgatatagc aaagaaaaaa cagataatat
    33781 gtataactca tttacctcaa attgctgcaa atgcagacac tcattattgt atagagaaag
    33841 atacttcaaa taataggacg tttaccaatg ttagtaagtt aaatgaatct caacgaaaaa
    33901 atgaaattgc cagacttata gcaggtaaca atataacaga aaaaactatt gaacatgcaa
    33961 gtgaaattat tgagttggct aaaaaatgtt agtgaaaaac aagcatttta ataggtgtaa
    34021 agaattttta tagaaatgct ttacatctat tttttatgat gaaattattt taaaatatct
    34081 agtgcctata ttgaagaaaa gtagatttaa aaatagaaga aaatttgtat aaatttgtaa
    34141 ctttgaaatt tctaaatgct taagtataat attatttatt aaggtagtag tgagggggac
    34201 ataaaatgaa taaaaaagat actatgcact taatttttac aattgtaatt tttattttat
    34261 tatggtatat tgtggtagca gtaagtgaga ttaataaaaa tattgaaagt tgtagtaata
    34321 aattagatta tttgtcacaa gagattatga gtactaaatc ggatattagt aatactataa
    34381 atgaagaaat gtcaaaaagt tatataacaa agagtattga cttaaaagta aaaaaaatcg
    34441 agaaaaaaga gtgtgttatt gatgtagatg ttcaattaag taaacttgga aaaaatggaa
    34501 aagtattttt tatgtataaa gaagatagtg ataaatggaa tgaaactgag atgacaaaac
    34561 atggagaatt atcatatgca tgtgaaatta agataaatac aggaagtgaa tatgactata
    34621 aagtagttac aagtggagct atatctgaaa gttctgatgt gcaaaaattg actaaatctg
    34681 attatatgcc tgaacaaccc atatttaatt ctgggataag agataataga gaatacttta
    34741 ttgaaatagt agaaaatagt aatcttttca atcatgagag tgaaaagtca aaaaataaag
    34801 tttatgataa tattagatta gaaaaagtag atattattgt aaatgaagga aaaaaagaca
    34861 ctatatacaa agccaaatta gctgaaggct tagatgatgg caaaactaat aattcaaata
    34921 gaaatcaagt gaattatgaa gtaagttttc ctaaaaggga tattgatgac ataatttata
    34981 ttaaagctaa acttacatac aataatggag tagaatatac aaaggatata actgaagata
    35041 taactatggg attacaagat ttagaaaaat aaatacatat ttaaataaat attcaaatag
    35101 atttgttcaa taaaatagag tataaataaa actgtagtag ttttacttat actctattaa
    35161 aaaattataa ttttaattcc atatatctag ccccttcaat tggattataa gtataaggtt
    35221 ctatatcata aaaaccaaac ttttcatata atccttgtgc acttttcatg cttggaagag
    35281 tatctaatct catgtgtgta tatccaaatt ttttagcttc ttcaatgatt tcttccaata
    35341 gtatttttcc tatttttaat cctctaaatt gatttcttac atataatctt tttaattcac
    35401 atattttacc ttcaagtttt tttaaagcaa cacaacctgc caaattttca tcaacaaatg
    35461 ccaatatcaa tgagcctgaa ggttttttat attttcctgg aagtgttttt aattcattat
    35521 taaagtcttg aaaacataag tctatattta gagaatttga atattcagta aatagaagtt
    35581 ttacgttttc aaggttttct aaatcttttt cttcaacaaa ttgtaaagtt atattttgag
    35641 ccattttatc cgccattata taaacatgtt tatataatga cttcacctcc ttgatatatg
    35701 tatatttttc ttaatatcaa ttagatttta ataccattac tttttcacca ccatagtcaa
    35761 gctctccatt aaactcaaat ccaaaatctt tataaagctt aatagccatt ttattgtctt
    35821 cgaatatact aagatatagt tcatcacagt tatattcatt tttaagatga tttacaagaa
    35881 aatctaatga tgcttttcca tatcctttac cttgatattt tgaatcaatc ataaatctat
    35941 caagccaaac tctatcatct tctaaacgac catacatagc aaatcctatt aaagaatttt
    36001 catcatatat tccaacaggt acccaagctg ttataaattt agattcagca atagaaagtg
    36061 cattgctttc tatataatct aactgacttt tatctacaga caaactaact aaatcatgcc
    36121 aattatttat gtctgcaatt cttacattta atttcaagat attaccgccc ttcaaacttt
    36181 ttgttacaat ctaatactat catattatgt attaaaaatc acttattaag attttaaata
    36241 aactttttaa atgaataaat tctcaggaaa aaggaattat aaatacataa taatacagca
    36301 taggagtaga tggatatatg aacaaaataa ataaaaattt caaaaatatt tggataatat
    36361 taggagctgt atcgattttt accatggtta taatttttaa taaaaattgt aatgttaata
    36421 aagagactca aatagaagct tttacaatta agaatcatga taaaaaattt gtatatccta
    36481 tgggaaatat aattggagta aaagcaaata cagatggtgt attggtctta ggatatgagg
    36541 aagaggatgt agactatatt ggaggcatac aaatcggtga taatatagta aaaatagata
    36601 ataaaaggat aaaaaatagt caagatgtat cagagatttt gaataagatt aaaaaaagta
    36661 aagttgaagt gacttttgag agaaaaaata agtataaaac agaagtaata gagactaaaa
    36721 aagaaaatgg caagtataaa cttggattat gggtaagaga taaaatatct ggaattggaa
    36781 ctatgacttt ttacgaccct agtatggaaa agttcaaagc aatcggtcat gccataaaag
    36841 attcggatac taatgaacta ttaaagataa agcaaggata tatatataag ccagaacaat
    36901 taaaaatagt aaaagctagt aatgaaaaag taggtaaaat aaaaggagat tttaatgaca
    36961 gcaatttaat gggtaatttc tcaaataatt cagagttagg tataagtggt aatattacag
    37021 aaaaccataa taaagagttt aatgtagcaa ataaagaaaa gcaattaata gaagttggaa
    37081 gaccgcaaga tgtaaaaata ggagatgcag taattctttt tgaggataaa aacaaaaata
    37141 taacaagcta tgatataaaa atagaaagta tagtatatga taaaggaaat tatagagata
    37201 tggtaataaa agtagtagat gacaagttat tggaatacac aggaggtatc gtacagggga
    37261 tgagtggagc tccaataata caaaataata aaattattgg tgcaataact catgttttta
    37321 gagataatcc gaaaaaagga tatggtattt ttatagatga aatgataaaa ttgtaggtga
    37381 ggcattaaaa aattttatta ttttatcaat tatctaggag gaatataatt ttggagtgtc
    37441 gaatatgctt tagagtagat aattaggaag caattgtgta aaaagtttag ttttctgtaa
    37501 taagaagatg ttttttaatg gggggatttt tagtggaaaa aatcaaaata gttttagcag
    37561 atgacaataa ggatttttgt caggtattaa aagagtattt gtctaatgaa gatgatatcg
    37621 atatattagg catagctaag gatggaattg aagcattaga cttagtaaaa aagacacaac
    37681 cggacttatt aatactagat gtaataatgc cacatctaga tggattaggt gtaattgaaa
    37741 aattgaatac tatggatata cctaaaatgc caaaaataat agtactatca gcagtaggtc
    37801 aagataagat aactcaaagc gcaataaatc taggagcaga ttactacata gtaaagccat
    37861 ttgattttgt tgtgtttata aacagaatta gagagctagt ttctaataga gttacacaag
    37921 ttgagccaaa acctagacca gttcaagaga ctcaaatgac tagaagtgat tttgttaaga
    37981 atgtaggaaa tatagagaca gaaatcacaa atataataca tgaaatagga gtaccagctc
    38041 atataaaagg atatttatat ttaagagaag caataaaaat ggttattgat aatgttgagc
    38101 ttttaggtgc agtaacaaaa gagttatatc caagtatagc taaaaaattc aatacaacac
    38161 caagtagagt tgaaagagca ataagacatg caatagaggt tgcatggagt agaggaaaag
    38221 ttgacacaat aaatcaatta tttggatata cggtacacaa tactaaagga aaaccaacta
    38281 attcagaatt tatagcaatg attgctgata aattaagatt agaacatagt atggttaaat
    38341 aaacaagaca taaaaagtaa ggctttttaa ttaaggcatt ggctataaat gcgtattaca
    38401 agcagcgaaa cggtataacc actagggtta taccgtttcg ctattttaat aaatataaaa
    38461 attttcttta ttatttgctt actatatcaa tataataatt ttattatact atggatatag
    38521 tatgtgtctt tacaagttgt aaactgacag tggtttattt tttaatataa atattgactt
    38581 tgatgcaggt aaactttgta tttttaagcg tattatggaa tatgttaaat aaaaaaatga
    38641 tgaaatatag tattgtaaat gccaaagatg caaaacaaac ttaaaacatt tattttattg
    38701 ttaagtaatg ctataatata atgtgatttt aataatgata gtggaggttt aaatatgaga
    38761 gtcgaggccc ctataaaagt agatcgaaaa accaaaaaac ttgctaaaag agttgaaagt
    38821 ggggaaatag cagttataaa tcatatagac atagatgaag ttgctgcaaa ctctttagta
    38881 gaagctaaaa taaaacttgt cataaatgcg gctccttcta taagtggtag gtatcccaat
    38941 aaaggtccag ggatattaac tgaaaataat atactaataa ttgataatgt tggagaagag
    39001 ttatttgaag aattaaaaga aggagaaact atagaagttg tagatggaaa gatatataga
    39061 aaaggaaaat ttttaggtgc aggagaagtt ttagacaagt atgaggtttc acaccaaata
    39121 aaggctgcct atgagaattt agctgtagaa ttggatagat ttatagataa tactatagat
    39181 tatgctaaaa aagaaaaagg atttatactt ggagaagtag aaattccaaa agtgaaaact
    39241 aattatgcta ataaacatgt attgatagtt gtaagaggtc aggactacaa agaagattta
    39301 agtactatgc tttcttatat agaagaggta aagccagtat tggttggtgt tgatggagga
    39361 gcagacgctt taattgagtt tggatatact ccagatgtga ttgtaggtga tatggatagt
    39421 gtaagtgatg aagctttaaa aaaggctagt gaaatagtag tacatgctta tacagatgga
    39481 agagcaccag gtcttaagag ggttgaggaa ttaggcttag atgcagttgt atttcctgcg
    39541 ccaggaacta gtgaagatat agctatgctt atagcctatg agtataaggc tgagttaata
    39601 gtagcagttg gtacacattc aaatatgatt gattttcttg aaaaaggaag aaaaggtatg
    39661 gcaagtactt ttttagttag actaaaaata ggttcaaagc ttatagatgc taaaggcgtt
    39721 aatttgttat acagaagtaa attaaaaata aagtacatat gggcattaat agcaacagca
    39781 ttatttcctg tgttggtagt tgcatcattg tcaccaggag ttcaacagtt catacaacta
    39841 atgcaattaa agtttagagt attattacag atgtaaattt taggaggata aatatgcata
    39901 ttaatatgaa atattatata gtcactatag gggctatatt tatagctttg ggtataggca
    39961 tgttagtagg atttaattta aataataatc aacaattaag tgaacaacaa gcaaatataa
    40021 taaatgattt ggatgataag tttaatatct taaaagaaaa aaatgataaa cttgacagtg
    40081 acttagcaag tgtaaataga gattatgaag aggcagttaa ttttataaat aaaaatgtag
    40141 ataagatttt agctggttcg ctgaatggta agagtatagg aataatatct gctaatgaaa
    40201 atgacgatta tacaaaaaat atagaagaca taataaataa atctaatgga agcattgcat
    40261 ttaatataat attaaaagaa aacataacaa atccagaaaa gttaaaggaa atgtcaacta
    40321 aactaggtac agatgtaaaa aatgcaaatg atgcagttaa ttatataatt gacactctta
    40381 aaaaggaaga tgcaagtgac attttaacat atcttcaaga actagatgta ataaagttta
    40441 attttattgg agatacatat ctaaaatatg attccgttgt aatagctggt ggaaatgatg
    40501 caaaagacag tacaaaacag tttgaaaaaa tagaaaaatt tgtagtttca aaacttaaat
    40561 cagagaataa atatttagta gaagttcaaa atacaggagt taaaacttct tatgtagaac
    40621 tatattctaa aaacaaagtt gcaactatag acaatattga tgaaggtata ggaagtatat
    40681 ctctagcgat tcttctacaa caaggtaata tagttggtaa ttttggtaga ttggatactg
    40741 caacttcatt gttgccatct attaaataga aataatttta aggagagaaa aaatggattc
    40801 ttatataagt ataataatac cagcttataa tgaagaaagt agaataaaat atacattaga
    40861 aagcatattg gacattaagc aaataaatga aataatagtt gtggatgatg gttcaattga
    40921 caatactgct aaggttgtat ctgagctaga aaatgaaaag attaaatttt ttaagttaga
    40981 taaaaataga ggtaaaggat atgctttaaa ttatggtatc aagttagcaa tgaaaaatgc
    41041 agatattata ggttttctgg atggagattt aggaagttct gctaaagaag ttgaaaaatt
    41101 aatagtacct atattaaatg gtgaggcgga tgttacaata gccaagtttc ctcctgcaaa
    41161 gagaaaagga ggtttgggat ttgtaaaagg tttagctaaa aattctgtgt ttgagatgac
    41221 tggtgttgag ttagatgcaa ctttatcagg tcaaagaata tttaaaagag aagttttaga
    41281 aaagtttgat gaaatacctt ttggatatgg agtagaagtt ggaatgacca ttgatatatt
    41341 aaagtatgga tttaaaatta aagaagtatt agtaaatatg actcataatg aaacaggaag
    41401 aaatttaaaa ggttttattc atagagggaa acagtattat cacataaaaa aggttttagg
    41461 acaaaaaaag aaagaatgga ggtaatatct tagtgaaaga ttatatactt tataccattt
    41521 tattattaac tggattattt ggaacctatg ctgtaattcc actatttaaa aatttattga
    41581 taaatggaaa tgtacttaga ccaaactata aaaaagatat gataccagta agtatgggaa
    41641 ttgtattttt gcctatgatt gtaatcaatg gaataatact tgctttcttt actacagaat
    41701 ttaagaattt agcgtatata tttatgttta tgtttggtat gatatccatg ttttttgcag
    41761 ggatactaga tgatgtcatt ggaaatagag atgtaagtgg tttaaagggg cattttaaaa
    41821 gtttatttaa aggaagtctt acaacaggag gttttaaagc tttatttggt ggatttgtag
    41881 ggcttatagt ttctgttgct atatcaaaag acataattga tataatagta aatacactaa
    41941 taatagctct atcaactaat ttaatgaatc ttttggattt aagaccagga agggcaataa
    42001 aagcatattt attcataatg gtaattgtat ttttaacatt gacaggattt gttcaagttc
    42061 ttccattact tatagtacca aatgtacttg catactttaa ttatgattta aaagcaaggg
    42121 ctatgatggg agatactggt tcaaacgtcc ttggaatatc tattggaatg ctcatttctt
    42181 ttgggtatcc atttaacatt agattaggat ggttaatatt tgtagttatt atgcatatat
    42241 tcactgagaa atactcatta actaagataa tagaaaaaaa taaactatta aattttatag
    42301 ataaattggg aaggtagtat tatgataagc aaaagagtgg ggattgttga atcaatagta
    42361 agtcaaactg aaactctaga tgatataaga gtaaatataa atggagaaat acaaaaggca
    42421 tataattatc caaaaatatc tggaactata aatataggtg acgaagtggt tttaaataca
    42481 acagcagtag aactgagctt aggtacaggt ggataccatt ttgtaataac taatttaaat
    42541 aatatagaat ctactttaac tgaaggtgga catataatga aacttagata tacgcctctt
    42601 caaataaaag tggattctgt tgaggaacaa gaaagtattt atcatgataa atttgcgaat
    42661 tttaaaggat tagaaggtct ttctgttgta gtagggactc ttcatagtat gttaactcca
    42721 tttgcagctt catttaaaag aaataatcca aataaaaaat tagtgtatat aatgactgat
    42781 ggagcatctc ttccaattta tttaagtaaa aatgtggata ctttaaaaga aaaaaaatta
    42841 atagatagta caataactat aggaaatgcg tttggtggag attatgaatg tataaatata
    42901 tatactgcat taattacagc aaaagaaata ctaaaagcgg atgcagtatt tgtcagtatg
    42961 ggacctggaa ttgctgggac aggaacaaaa tatggattta cagggattga acaaggctct
    43021 attcttgatg ctgtaaaaaa acttgaagga agagcaattg caattccaag aattagtttt
    43081 gctgacaaac gagaaagaca tcaaggtatt tcacatcata gtatgactgt atttaaagaa
    43141 attgtaaatg taaatgtaga cataccaata actatatatg atgatgaaaa attgaacttt
    43201 ataaaagagc aaatcaattt aaatggttta gacaaaaagc ataatataat ttatatagat
    43261 aataataaaa cgaaagagga tttagactat tttaatctaa aagtaaagag tatgggaaga
    43321 aattatgaac aagatgaggc atttttcaaa gctgcaagca cagcagcata ttacttaatg
    43381 gaggtttaag atggtattag aagaaaaaac tattagtagt gatagggttt atacaggtaa
    43441 agtaattact ttaaaggttg atactgttga aattccaggg caaggatatc aaaaaaggga
    43501 gttagtagaa gttggtggag cagtaggaat agttgcaatc acagatgata ataaagttgt
    43561 gttagttaag caatttagaa aacctataga aaagccaatc tttgaaattc cagctggtaa
    43621 actagaaaaa aatgaaagtc caaaagaatg tgctgaaaga gaattaaaag aagaaactgg
    43681 gtatagtgca aaaaatatta agctaataca taaatttttc acttcagcag gtttttctaa
    43741 tgagataatg tttgtatatt tagcaacagg tcttactcca ggagagaata atttagatgc
    43801 agatgagttt ttagatgttt atgaaattga gcttgaagaa gcatataaca tggtattaaa
    43861 aaatgacgtt gaagatgcaa aaacatctat tggattatta ttagtaaaag atatgtttaa
    43921 aaattaatat ttataaaatg aataaccctt tgtcctaaag catattattt tataaaggac
    43981 aagggggaat taaattgaga agaacatata gaaaaaatga ttttagagaa ttaaatagac
    44041 aaataattat tataggattg ttgtttatga tgtctattgt tgttgggtct tacataaata
    44101 aaatattgcc aggttctagt aacaatatat taaacaatat aaatcctgct gtagagtatt
    44161 ataatctaaa tataagcata aaagatacag tgatacaaaa tttaaaatca gatgcaatct
    44221 ttatgggctc aatagctcta ttaagtctat ttgtagtaac aattccagca gtgttggtag
    44281 cttttgtatt aaaagggatg tcaattggtt atacaataaa tagttgtata ttggcattaa
    44341 aatttaaaag tataaaaatg attttaataa tattatttaa aaatttgatt attattccat
    44401 gtgcaatcat attagcatta attagtttaa gttattttaa agaaatggtt tatgaattta
    44461 aaaagaaaag tagaaaaaat atgcaatttt taattaagag gtatatacta aatattataa
    44521 ttataatagc actatcattg gggttgcaat taatattaaa tactgcaagt attggtatta
    44581 ttaagttcct agctaaataa aggagtttat aatggatatt atagagggat atatagatta
    44641 cataaaagat aaaaaaaaat tatcagagaa tacagtggca tcatacttta tggatataaa
    44701 aaaatatatg gaatatataa atcaaaaaag cattaaacta gtagatatag tagaaaatga
    44761 tattataagt tacttaataa agttggaaaa agataatgta tcaatagcta caatagcgag
    44821 gatgatatcc tctataaaat cttttcatga ttatttattt ttaaatcata tatgtacaaa
    44881 taatcctgca aaggatataa aaaaacctaa aataaaaaaa gaaaatataa atatacttac
    44941 agaagaagaa attgaaagac tattaaattt tccaaagtta acaacaccta agttgattag
    45001 ggacaaggct atttttgaag tattatatgg tactggtata aaagtatctg aattagtaga
    45061 gatgaatata gaggatattg acctagatat tgattatata tattgtaatt catgttgtaa
    45121 aaatcaaaga gtgataccac tttgtgatat tacaaaactt tacttagaaa agtatctaaa
    45181 agaagcaaga cctaaaatgg ctgcagaagg tgaaaaatca ttattcgtaa gttcattagg
    45241 tcaaaggttt acacgacaag gtctttggaa agtcataaaa aaatattcta atctagccaa
    45301 tatagataaa aatataaatc ctacaatgct tagacattca tttgctattc atttgttaaa
    45361 tgaaggtgct aacattgctg ttgtaagtaa aattttagga aatgttaatt tatctagttt
    45421 gcaagtatat ttaaatcata tagataaaaa cgtgagaaga gaaataaagg agaaacatcc
    45481 tagaaatgat gttgatgtag aattacaaaa agcagaagct aaatagacta tatagcaaat
    45541 tttataattt agaaggagca tatttatatg agcagagtaa tttggattgt aattgatagt
    45601 gttgggatag gagcattacc tgatgctgaa aaatttggtg atagtaagga tgtaagtacc
    45661 cttggaaata tatttaagga atatccagat attcagattc ctaatatgag aaatttaggt
    45721 ataggaaaca tagaaggtat agattttttt gaaagtataa aagaaccaat aggttgtttt
    45781 ggaaagtgta aggaaatgtc tcagggaaaa gatactacta caggtcattg ggaaatgact
    45841 ggtataatag ttgacaaacc atttaagaca tttgaacatg gattctctaa ggagataata
    45901 gaagagtttg agaaaaaaac tggaagaaaa gtagtaggaa ataaaccagc ttcaggaact
    45961 gtaataatag atgagtatgg agagcatcaa ataaaaactg gagatgtaat agtgtataca
    46021 tcagctgata gtgtatttca gattgctgct aatgaagaag taattcccct agaagaactc
    46081 tataatatgt gcaaaatcgc tagggaaata atgatggggg ataatgcagt agctagagta
    46141 attgctagac cattcatagg taagaaaaaa ggtgagtttg tgaggacttc aaatagaaga
    46201 gattattcac tagacccatt tgaaccaaca gttcttgata atataaaaga atcaggactt
    46261 gatgttttag cagttggaaa aatagaagat atttttaatg gaaaaggaat tacagatgct
    46321 atccacacta aaagcaatat ggatggagtg gatgaaactt taaattatat gaaacaagat
    46381 aataaaggtc taatatattc aaatctcgtt gattttgatt ctaaatatgg tcataggaga
    46441 gacccagaag gatataagaa agctcttgaa gagtttgata gtagacttcc tgaaataatg
    46501 gctaatatga gagaagatga tattttaata atcaatgcag accatggaaa tgacccaaca
    46561 tataaaggta cagaccatac aagagaatat atacctgtta tgatttatgg caataagatt
    46621 aaaaaaggtt ttaatttagg agtaaaagat acttttgctg atattggagc aactgttgca
    46681 gatatactaa atgtaaagtt gcctaaacat gggtcaagct ttaaagaaga tttattttaa
    46741 actataaaat gataaaaact tagcttaata ggatggagag attggaatgt ttgaaaagat
    46801 agcacaaagt agtaaattta taaattctaa aagtaatata aaacctaaga ttggtttgat
    46861 attaggttct ggactaggtg atttagcaaa tgatatagaa gaccctgtca caattaaata
    46921 tagtgaaatt ccaaacttcc ctgtatcaac agtagcagga catgctggac aacttgtaat
    46981 tggaaaactt gaaggaaaag aagttattgc tatgcaaggt agatttcatt actatgaagg
    47041 atattctcag aaagaagcta cttttccagt aagggttatg aaagaattag gagtcgagat
    47101 tcttatagta actaacgctg ctggaggcgt aaataaagaa tttaaagcag gagatttgat
    47161 gcttataaga gaccatataa actttagtgg aagtaatcca ttagtaggaa aaaatgatga
    47221 cagatttggt gctagatttc cagatatgtc agatgcatat tcttctaaat atgtagatgt
    47281 agttaaaaac tgcgctaaag aatgcaatat agatgtcaaa gaaggcgttt atatgttttt
    47341 tagtggtcca aactatgaaa caccagcaga agtgagaatg gcacaaattt tgggagctga
    47401 tgctgtaggt atgtctactg ttccagaagt catagtagct tctcactcta atataggagt
    47461 tattggtata tcttgtataa caaatatggc tgctggcatc ttaaatcaac cactaagtca
    47521 tgaggaagta atagaaacta ctcaaaaagt taaatcagaa tttatgaatt tagttaaaac
    47581 aacggttaaa aatttataag ttaaagctta ttatagattt tttgaggaag tttataataa
    47641 aatagttaat gtttaatttg aaaagaatta ataaaaagct gtcttgatat agaaagttat
    47701 ttctaataaa ggacagtttt tttataatac tacaacattt gaaagtgttt taaagtttaa
    47761 tatttattta aattattata ggttagaatg gagatttcaa ttatgagaat gtatgatatt
    47821 ataaaaaaaa agagagataa cctagagctt agtaaaaaag agataaacta ctttatagaa
    47881 aactattcaa agggagatat acctgactat caagcttctg cactattaat gtcgatttat
    47941 ttaaataaga tgaataaaca ggaaactgta catcttacag aagcaatgat gaactctgga
    48001 gacatgataa acctatctga gatagatgga ataaaggtag ataagcatag tactggtggt
    48061 gttggagata agactaccat agctcttata cctttggttg cttcatgtgg agcaccagtt
    48121 gcaaagatgt caggtagagg tcttggtcat actggtggta ctattgataa attggagtct
    48181 ataccaggtt tttcgacaga aatggagata agtaaattta ttgattctgt aaataagtct
    48241 aaaatagcag tttgtggtca aagtgcaaag gtagcaattg cagataagaa aatatatgct
    48301 cttagagatg ttacagcaac tgttgataat atatcattga tatcatcaag tgtaatgtct
    48361 aaaaagttag cttcaggagc tgatgcaatt gtgctagatg taaaaactgg tgatggagca
    48421 tttatgaaga cattagaaga gtcttttgag ttagctaaat ctatggttga tataggtact
    48481 ggtatgaata gagatacaat agggattgta acagatatgg atgaaccttt aggttttgca
    48541 gtgggaaact ctttagaagt tatagaggca attgagacat taaaaggaaa tggacctaaa
    48601 gaccttgttg agctatgcga agtattagga gcatatatgt tggttttatc aaaggtagca
    48661 catgattttg aagatggtgt tgaaaaaata agagaatcaa taaaatctgg tactgctata
    48721 caaaaactca aagagtttat agagaatcaa ggtggtaata aagatgtagt agatgattat
    48781 tctttattca aaaaatcaaa gtataaatat ccagttaaat caactaaatc aggttatata
    48841 agcaaaatta aagctgaaga tgttggtgta tcggctatga ttcttggagc aggtagagaa
    48901 actaaagatg atattttaga tttatcagca gggataattt tagaaaagaa agtaggagat
    48961 tatgtaaatg aaggtgaagt tttagcttac atgtattata atgatgaaca aaagctttca
    49021 ttggcaaagg gaagatttat tgattcctac tctattgtag attcaaaaat agaaaaaaat
    49081 aaattaatat atggtattgt aactaaagaa gagattaaaa agttttagaa aattttagaa
    49141 aagtgattat aaaaggccta acatgtcaaa aataatgtta ggttttttat tttttgataa
    49201 actataaatt ataccaaaaa tatatatttt aaaacatttt ttacaatata aataagttta
    49261 ttctacaaga tgattgaaaa ttaaagtatc tagttttata atagaaaatg gataaatata
    49321 cataaggagt agattatatt atgaacttta aagaaaatag attgaaaata gcagtattaa
    49381 taattgttat tttgattatc ttagcaggta tatttgtgtt tatacaaata ggtccttatg
    49441 ataaaaataa caaaaaagat gtaattatcg acgttccaag tggagcatct gttggaaaaa
    49501 tatctgacat attatatgaa aataaattaa taaagaatga actattattt aaacttttgg
    49561 taaaggttag caataaagct ccgtctataa aatcaggaac atacttactt aatcaatcgt
    49621 attcaaacaa tgatataata agtcttttag tttcaggtaa aatatatcag gatggtataa
    49681 aagtgactat tccagaggga gctacatcta aagaaattat agcaatgtta gtaagtaaaa
    49741 atttaggaga taaagctact tttgaaaatt taataaaaaa acctcaagaa ttttatgata
    49801 aattttcata tttgaaggaa gatggaataa cctctttaga agggttcttg tatccagaaa
    49861 cttattattt taattcaaag aaacaatcag aagaagatat tttaagcgaa atgttaaaag
    49921 tatttgacag taaatacacg gacaagttta aaaagaaaca aaaagaatta aatatgactc
    49981 ttcaagaagt aatggaaatg gcatcaataa ttgagaaaga agctgttctt gacaaagaca
    50041 gacctataat agcaagtgtg ttttataata gacttaaggt aggtatgcct cttcaatcag
    50101 atgctacaat acaatatata tttgaagaga gaaagaaaat tgtaacatat gatgatttaa
    50161 aaattgattc accatataat agttataaaa ataagggatt acctcctaca ccaatatcaa
    50221 atcctggtat aaaatctatt gaagcagcat tatatccaga gaaaacagac tatttatatt
    50281 ttgtagctaa gattgatggt ggaaataatt atagtacaaa ctatcaagac catttaaaat
    50341 acgttaaaga atataaagaa gcaagggata aacaatcaaa agatacaaaa gcaacaaata
    50401 aagaaaatac aaaaaaataa accatgatta taaaaagtct aacagggtaa gaataatgtt
    50461 gggctttttt attgaaaatt gttattctta gatttataat aaagaaagtg taaatatata
    50521 taacaatatg aatttaaaaa ataataaatt aatataaaac ttggatattt attattttag
    50581 ggagtgtttt tatgagtaat atagttaatg atttggttga agattatata agagtgacat
    50641 taaaagaaaa agaaggattt ttaaaagatt tagaaattta tgcagaggaa aatagtgttc
    50701 ctataataca taaagaagtt tcagatttat taaaagtctt gttaaaggtt caaaaaccaa
    50761 agagaatttt agaagtagga tgtgcaattg gttattcttc tatttttttt gcaactatta
    50821 taggaaaaga tgcagatata ataactgttg agagaaatga aaaaatgata gaaaaagcaa
    50881 aagaaaacat aaaattagct ggatttgaca ataacataac tatactagaa ggagatgcag
    50941 aagaaaaact tagtcaagtc caaggtgaat ttgaccttat atttatagat gcagccaaag
    51001 gtcaatataa gctatttttt gatttagtta tagataaatt aaaagatggg ggacttttag
    51061 tatctgacaa tattttgtat aaaggtatgg ttgctcatga tgattttgtt gtaagaagaa
    51121 aaaagactat agttaaaaga atgagaaagt atttagatta tatatgtaat tgtgactatt
    51181 taagcacatc attggtacca ataggtgatg gtgtagcact aagttataaa gaaagtaaaa
    51241 gaggtgatgt agatggaatt aaataaagta gaacttttag ctccagcagg tgatttggag
    51301 agattgaaaa tagctataac atatggagca gatgccgttt atataggtgg agaaattttt
    51361 ggaatgaggt ctgcagcgaa gaattttagt aaggaagata tggcagaggg agtagctttt
    51421 gcacatgaaa gaggcaagaa agtattcgta acagtaaata taatacctca taatgaagat
    51481 tttctacaat tagaagacta tttgttggaa ctagaagaga taggaataga tgcagttata
    51541 atagctgacc caggagtgct tagtgtcatt aaaaaagtaa ttccgaatat ggaaatacat
    51601 ttaagtacac aagcaaatac aaccaattat ctaagtgcaa acttctggta cgagcatgga
    51661 ataaaaagag ttgtagtggc aagagaatta tcttttgatg aaatatatga gataagagca
    51721 aaaacacctt tagatatgga tatagaagcg tttatgcatg gtgctatgtg tatttcttat
    51781 tctggcagat gtttaataag caactatatg actggaagag atgcaaacaa aggttcttgt
    51841 gctcaatctt gtagatggca atatcatttg gtggaagaaa aaagacctgg tgagtatttt
    51901 ccaatatacg aagatgaaag gggtacattc ttctttaact caaaagattt atgtatgata
    51961 gagtatatac cagagttaat caaatctggt ataacaagtt taaaaataga aggtagaatg
    52021 aagactgcat actatgtagc tactgttgta agagcataca gaatggcaat agatgaattt
    52081 tacagagacc cagaaaactg gaagtttaat ccaatgtgga tggaagaact aaaaaaaggt
    52141 agtcatagac attttacatc aggtttttac ttgaataaac caacaacaga agaccaaaat
    52201 tatcaatcag catcatatgt tagaaactat gattttatag gtatagttag agaaacagaa
    52261 gatgaagatg gtcttattgt tgttgagcaa agaaataaaa tgtgtgttgg tgatgaaata
    52321 gaagttatgg gaccatataa agaaactatg tttactaaaa ttgaagaaat gtataatgaa
    52381 gaaggagaag ctatagaatc agctcctcat cctagacaaa tagtgaagtt aaagctatca
    52441 gtaaaagttg gtaaagatta tatgcttaga aaagttatag aagaaaaggt tgaagaataa
    52501 taaaaaattg ataaaaatag tattagcccc ttagaaattg tcaataatga aattatctaa
    52561 ggggtgattt catgtcaaaa aagaagactc catttttgaa aaaagtggga aagagaagct
    52621 ggtgtatatt tactataatt ttaataattt atagtgtttt aatttatagg ctagttgata
    52681 tacaagtatt aaaaggtgat aaatacaaac aaagtgttga atcacaaagc gttgagaaag
    52741 tcgagttaaa tagtggaaga ggaataatct atgatagaaa caacaagaag cttacagata
    52801 caagtaaatc tcaggtatta attgttgaaa aagaaaaatt aaataataac tataaaattt
    52861 tggagcttat taagaaagct actaagatga atgatttaga tatatataaa gctgtacaag
    52921 agcaattgac acgccctata atacagattc agactaaaaa tatcgatatc gataagagta
    52981 tgaaaaaaga acttgagaaa aatggaataa tggtagaaga aaaaactatg aggtacgcaa
    53041 aagatggttt attatcacat acaataggat atataaaaga agatgataaa tcaggtcaat
    53101 caggaattga aaagagtatg gatagtgtac ttagaaattc aaatgaaaag tatataagtg
    53161 cttttaaagc tggagatgca ggaaatgaaa aatctctaaa catactaaag ggaagtgtaa
    53221 aaactgttga taataaggat aaagatagac atctaaaaac tactattgat tataacattc
    53281 aaaaaaaatt agaacaaata ctaaataaag aagaaaatcc tacagcagca ataatctcgg
    53341 aagcatctac aggtgaaatt cttgcaatgt gctctagacc taattttgac caaaatgaca
    53401 tatcaaaaag tttaaaagga aaaaatggag aatttgaaaa tagagttata aaagcgacat
    53461 atccaccagg gtctgtattt aagatggtag ttttattttc tgcacttgaa aatggtgtta
    53521 tagatgagaa ctatacttac aactgtacag gtaagactaa agttgggaat actaatgaaa
    53581 tactgcgatg taataaaaga gatggtcatg gtttccaaaa cttaagacaa gctttttcta
    53641 attcatgcaa tcctgcattt ttagatatag ctatgaaact tggaaaagaa aagatactca
    53701 aatctgctga aaaattacat ttatttgaaa aggttgatat tggtcttgat gaagaaaaaa
    53761 ttagagaagc tccaaaaaac atatcaataa gaaatttagc tataggtcaa gaaaatatag
    53821 aatttacacc acttcaaata aatcaaatga ctcaaataat agctaataat ggaacattca
    53881 aaccactata cttatataaa agtcttgtgg acaataatat gaatacaata aaaacttata
    53941 agtcttcaaa aaaagaagaa cttatttctc cttatgtgtg tacacaagtt aaagaatata
    54001 tgaagtctgt atctaggact ggtacagcta aagacctaaa agatattgaa ggtggttgtg
    54061 gagttaaaac tggtacagct caaagtagtt taaataaaaa agctatagac cacggatgga
    54121 taacaggatt ttatcctgaa gaaagaccta agtatgtaat aactgtgtta gtagaaggaa
    54181 ctcaaaaagg aaataaatct gcaacaccta tatttaagga aatatgtgaa agtataaaat
    54241 aaattatgta ctataaaatt taaggatata tcgtaacttt gattttagat agaaaatttt
    54301 gtctaatgat gtacgatata tccttttaaa atatagtatt aactttcttg aacaagctct
    54361 ttttctagtt ttttaagagc ttttttttcg attctagata catatgacct tgatatatcg
    54421 agtttttgtg caatttctct ttgtgtctta tagccataag gagttaaccc atatcttaac
    54481 tggacaattt ctctttctct aggagtaaga attttgttta gttgttcgta aagttttcca
    54541 acttgaactt ttagttcaac ttcatcaaga acatagttag cctctgtacc aagtatatct
    54601 aaaagactta tttcattaca cactactctt tatatgttat tggtattact ggtcttcatg
    54661 taatttcaaa tggaccatta attcaaaaga atctagtttt tgttctttag acttataata
    54721 aactgcttta tcaattacag attttaggag tttatttttt ccaagggaat ctgaatcatg
    54781 gtaaagtgat aacacagttt taatatcttc tattatttta gaattgtctt ttttaacagt
    54841 actcaatcta ttttttactg tcttaattga atctttaatt tcttcagttc ttgaacttat
    54901 attgttggac ctttcaataa atgtatcttc atcatatatt cctcgttcta gtaaatcata
    54961 taacttattt ttttgcttgc ctaattcttt taattcagtt tctaagccct ttaagactcg
    55021 tttttgaaat tctatattac tatctttatt atttttatct aagtctatat cagatgcttt
    55081 taattgatat ttttttacag tgtcttccaa agattttaaa atggcagctt caataaattc
    55141 aaatcgagaa cttttattgc aaccaggatg ataacaaatt atatagtcgt ggtctgcata
    55201 tggtctatat actaatggtc taccacaatt tttgcaaatc actattcctg caagtggatt
    55261 ttttatttga ttaccatagc tgacatgacc attttttttg agtatatttt gagctttttt
    55321 ccatgttatt tcacttatta aaggttcatg ctttcctttt gcctcaatcc attcatcttt
    55381 aggtcttagt ttaactgttt ttattttatt tggattttta gattttttgt agtccttttt
    55441 ttgccactga atgtagccac aatatgcctt attttttatt atatttgtaa ttgcagaatt
    55501 gtaccaatta gcacctgtag cagttttaat gcctaagtta tttaggtatt ttgatatttt
    55561 actacaaccc atatcttcat taatatataa gtcaaagata gtcctaacta catcagcatc
    55621 tttatttggt acaagtattc tttcttttct accagttgtt acagcatcat atccaaatgg
    55681 agcagaggtt cctatgaaat tcccttcttc aactgatttt attctacctc tttgcatcct
    55741 tcttgatata agttttaatt cttttcttgc cataaatgct tcaaattctg aatactcctc
    55801 atcaaattca tctgttaggt cgtatgtttt tctaggtgtg atgattttgg tcttactttc
    55861 tttgaatgtt tctaatatga taccttggtc tttcatgtct ccacgaccaa gtctgtctaa
    55921 gtccattact aagactgcat catatttatt ttcttcaact tcttttagaa gttcaagcat
    55981 tttgggtcta tgtattatac tttcaccaga aactaattct tcttttatct caattacatc
    56041 taagttttgt tcttttgcta gttttagtag ggttgattta tgtctactta aagtttcaaa
    56101 ttcgccttgt ttttctgcct cttcatcagc acgggatttt cttaagtata tggcaacact
    56161 cataataagt aatcacactc cttatgcact attatatagt aaatcaatag agtttaaaat
    56221 atagaaaata agcatgtcaa aagttaattt aacttttgac atacttattt tctataatat
    56281 taatgcctta taatccttta atatcattta gattagtttt tgcatattca ttatccgggt
    56341 taagttcaag cgccttattg taagattctc tagctttatt aaattctgat ttactcataa
    56401 aaataacacc tcttaaattg taagcatcac tagcgtctat tttataagct tcattatttt
    56461 tatctagata ttctaagtat ttatcaattg actttaaagc ctcatcatat cgttgtaact
    56521 ctatataaat atatgattgt gtataatatg caagtggatt tttatcatca atttctatag
    56581 cttttttgat atcaatagca gctttattat aatccttatc ttcatctttt tctgtttctg
    56641 acctagcgat tttgacataa ttagagctaa gagctctttt aaagtcttta tgccataata
    56701 atttatattc attatcttcg attataaaat atctatcaaa atttgcagta tcttctttat
    56761 tttcagtgat atactttata gtatcagttt cttttatttt aacaagattt gtgtactctt
    56821 tattagaata tttgtatttc tctactttat tttcttcacc aagtttataa tcttttaggg
    56881 tttgaagttt aaataaagta tcttgatatt cttcaaattt ttctagactg acactttcct
    56941 tactgtcttt acttaataaa ttatatgcta cttcgtagtc tttgatttct atactatcaa
    57001 ggtacttttt agctacttct gtagcacttt cttttggagc acatccaacc attgatatca
    57061 taattaaaaa tgatactaat attgctgtta tttttttact gattatcata atataatccc
    57121 ccttatattg tctctcatta attttatttt atcaccatat tctaccaaag tcattaattt
    57181 aagagtgata tttttcatta atattatatt aagtaataat aaccttttaa atttatggta
    57241 aaattttcct gaaaagtatt atataattta ggtgaaaata tttaagagaa ggagatatta
    57301 tgaaaattaa aaaattatta acaatagggt tatctttatc tatatttatt gctagttgcc
    57361 ctatatctgt aaatgctctt gataaaattg aatcaattaa aggtgcagat aaatacgaaa
    57421 ctgctggtat aattgcagac aaacaaaact atactacagc tatattaatt aatgcagaca
    57481 gtacaatggc tgatggatta agtgcaagtg gacttgcagg agctataaac gctccaattc
    57541 ttttgactaa gaaaaataac ataccaaatg ctacacttaa aagattagaa aaggcaaaaa
    57601 aagtatatat aattggagga gaaaactcta ttgataaata tactgaaact gttctaaaag
    57661 gcaaaggaat agagattaaa agacttcaag gtagtgatag aattaagaca agctataatg
    57721 tcgcaaaaga aataaactca attaacaaag taaataaagt catattgact aatgcattta
    57781 aaggagagcc tgatgcaatg agtgctgcac ctgtagcagt tagagataaa gcagctatag
    57841 tattaactga tggaaaaagt gttccattta atacaactgg tgtagaaagt tatgtaatag
    57901 gtggtacttc atcaatgaat gacaaaatag ttaaggatac taattcaact agattaggtg
    57961 ggacagatag atatgatact aacaaaaaga taataaataa attttatagt ggagtaaaag
    58021 aattttatat agcaagtggt actgatttag tgtatgctct tgttggttct actgttgcta
    58081 aaaataatgc tattgtgtta gttgataatg atagtaataa aagtgtattg aaaagtacaa
    58141 ctaaattaac tgctatagga aatttgagtg atagtatatt acagcagtgt ttaaatgtaa
    58201 caaaaaatat aggcgattct aatactggaa gagaatatac agtagaagat gctgctaatg
    58261 cagtgaaaaa actattaggt gtgaagaaat tttattacga acctaattat tcagaagatg
    58321 aagatttaat atttctacta gataaaaatt ttgatttttc aggaaaagag tactatgtat
    58381 ttgcttacat taaacagggt gcagagggtg atgttagata ctgtgtagct aaaaatgata
    58441 tgagcaaagt ttatacatat gatgttaatg gtaatatgaa agtatgtaat ccagatgatt
    58501 ataaaaataa aggaagtata acagaggaac aagcaaaaca gatagcatta aaagaatgtg
    58561 ctaagagaca taaagtcagt atcaataact tagtagttga tatgatagat tttagagatg
    58621 atatatatag tggtaatgtc tatgctgtta aaatcaattc aaaaaatagt aatggtactt
    58681 ttggttggtt ttttatagat atagaaactg ggaaagttta taattaaaat tagaactttt
    58741 aaacaagtgt ttttaattat ataatttacc ataatatgtt ataatatttt tagcaagaag
    58801 atttaactta caatctatag agtggagttc atgtacaaaa gattatcctc ccaacgattc
    58861 gaagggaggt gagttcatgg ataacttttt gtttaatgtt ttagctagtt taacagctag
    58921 tgtggtagtt tacttaatta gtaaactatt caaaaaagca aaaagccact ctcgcacaaa
    58981 gagtgactta cgagttgaat ttaaatttat atttaaatcc aaaaaataaa ctctgtttat
    59041 gatgaactcc actctaacgc aaaatagatt gtagttcttc ttgcttttat tataccacaa
    59101 aacattataa ataaaactgt tgtttataaa aaaatgcaaa gtaaaatttt ttataaacaa
    59161 tgataaaaat tttattatag agctattaac ttattaaata tctgtaaatg agcagatatt
    59221 tcataagtta atatttattg tttacataaa atatttggta aaaataagta agttttatat
    59281 gttataatag ttgtagcaag aataataatc taaagtggca agcatgtcag ctggtgttat
    59341 atcagtttat atttatgata aaataaaaat ctcccaaacg ccaataagaa tgatttaaaa
    59401 aaataatatt ttcacttaaa aataatcact ctttatagga gtaaattatt ttcttgattt
    59461 tattatacta caaattggta cagatattta aaaataatat attcataata ttataaatag
    59521 ttttgcagtg agcgatattt ttgataaaat agggcttaac agttgaaaca taaggcattg
    59581 agggtatatg ataaatatta tcatttgcac tactcgtggt tcactgcaaa tttgagagaa
    59641 ttgtatagat gtaagtcttg gaaatgctca atttattttg gggttttata ttaactaagt
    59701 ggtatgtaaa gtcgtaaatt acgaccgtac ctttcgtaaa ataacaatcg ttttatatta
    59761 actaagtggt atgtaaagct ttttgagtat gagtacaagc ataggaaaat taatagtttt
    59821 atattaacta agtggtatgt aaagaacaaa aaagatacat ctgtaactaa tttttatact
    59881 gttttatatt aattaagtgg tatgtaaaga cagatataat atcaaaataa ggttaggact
    59941 tttaaaagca tagccatatc agtaaaaatt taattatcat ttaaaaaata aatttttatt
    60001 taaagaatac acataaatat ttccagactc aactctctta aactattttc atatctttta
    60061 gtagatacct ttgttgtttt ttaatcttta gcaacttgtt cttgagtgaa cctcttattt
    60121 tttctaagtt atttcaagct tttcaaaaaa ttctctattt atattcatca cacatataat
    60181 acaattaatt cagctttaat tgccaatatt tagtttttct gtatctgata aaccaagaat
    60241 ataatcagta tataaaccaa aaattttagc aaatattatt aacccatcgt ctcttgttgg
    60301 tctttcacca gactctattc tattcataac acttgtattt atatttgttt tttcaagcaa
    60361 ttctttttga gaactattca tattttccct aatatattta atcctttgat ttacatccat
    60421 acataattat ctcgaaaagt ttctgttttg gaaatattgt tattgaaata tagcaattaa
    60481 tgtgaatata tgaaaaagat acactatgat tttataaaaa agaagacata cataaaattt
    60541 atacttacaa agtgttgcaa atgagttagg ttttaaaaat gcatcaattt attttaagta
    60601 caggaaaggg gaatattcaa ttagagttga tatgttacct ataaactatc taagatactt
    60661 gattatgata tagaaaattt ttttacaaat taaatttcta agatagaaat ttaattaaga
    60721 ggatgatgag gatgaataat ttacaagtaa tataaagaaa taataagaga attttaaatg
    60781 catagcaact agcagatata tatgaaaatg atgtaaacaa tatataaact aacttcaata
    60841 gaaataaaga gaatgtaaat tatgttttat tacaattcga gtatttgaaa gaatttaaga
    60901 actaatctat taatagtcag ttgatttcaa aacattctag tcaattatac ctttggatcg
    60961 aaagatgtgc aaatagacac tgcaaaatat tagatattga taaaacttgg gaacaatttg
    61021 acaatttaga gaaaatatat ttcaagatta agcgagagaa actaagctgt atagaagatg
    61081 tattaataga aaatttaaga tttaaggata caaattaata aagcaataat atggcattag
    61141 atgtaaaaat agaagttaaa ataataaaag atgttgttat attaaatata acacattgga
    61201 aaaaagaaac aagtctatta acagttaaaa tagctagaag tcaaggtgat ttaagttatg
    61261 taaaatattt tgctaatgag agctaagagc ttcttaacaa gagttttggt gtgtctcttg
    61321 aaacaaggtt aacaattaat aaaagacgaa tggcagaaga aggcgtatgt aagtttaaaa
    61381 gagataagtt aaacaaacta gatactatgt aagaggataa gaaacttata gaagaatatg
    61441 ttacttttgt aaaggattta gctttaaaat atagaatata aagtgatttt aagtaaaaat
    61501 tgtaacaatt aaataagtat aagacaagtt tatgagttca tattttataa caaggggtga
    61561 tgttatgaaa atactacaac aatttaaacc atacaaatat gataaagaaa aaaatataga
    61621 atatgatgaa aaaattatag ctaatcaaaa cacagaagtt tatatagtat atccacgtat
    61681 atctgatgaa gaaaatagga gaagatggga agagttcaat gaagtagcta aagaagtagc
    61741 tattaatata gctatgaaga aagttgagac agtagaaagt taagagaata gagaagttgc
    61801 taatacttag cactttctca tagaagaaaa ttggacaact atttttaaat aattaggaat
    61861 aaaaaagtta aatcatattt gaaaaaaggc gataaaattg ttgagtattg ttattagtaa
    61921 taagaatata ttaactatgt attaaaagaa attataagtt tttagtaaat atagtattta
    61981 aggatattaa aactggtaaa aaatatcatt tagactatta aataaaaaag tgctggtcaa
    62041 agtagcaaca caataaataa aaaaacttat agaaattata agataaaaag atgagatttg
    62101 aaatggtcga agttaatata aaaattaaag gtgaagtaag tgaaataatt aactcaatta
    62161 gaggtatatt taatagcttt gatgaagaat taatattaga tataaaatca gagtaagaat
    62221 ataaaggtag atacgtagaa agttataagt aattcaagac ttaaattaat ttctagtttt
    62281 tttaatgcaa aaatttaata aatttcaaaa tataataatt ctgacatcta aaaagagcta
    62341 ttaaaaatga ataatattga ctattaagat atgaatagtg tacatatatt aaattaagat
    62401 atcaagtagg ttaattttat ataatgatgg ggctcaaatt gaagaggcga tataaaaatg
    62461 tattaatata tataaatata agaactataa tacatattaa ctgtaaaatt aagtttatag
    62521 agttatattt aacatttaat gaactgaaaa ataaattagc aaataatgaa aaaacaacag
    62581 taataaatga gaataacaaa gtattttcag gattagtgga tttttctaat tgagctttaa
    62641 tcctagtttg ttcaatttcg atatttctaa tattatcaat ttatttgtaa taattatcaa
    62701 tttttgcgaa atatttttga taatttatag aactttatat attttccttg aagtattttt
    62761 cgcccttatt gtttggtttc caattttaaa actcataaac tcccaataaa ttcatgtata
    62821 atatacctta atttataata tatttaagag tttatttcag taatttttcg aacgattttg
    62881 atatatttca tttatagttt tcaaaaactt atacaaaaaa gagtgtttca tctttctaaa
    62941 cactcttttt ataagaattt gaataataat tttttaaaaa ttgataatat ggttatttct
    63001 ttttcaagtt tatagtttcc tcatttccat tccaagatat aattagcttg taactagatt
    63061 ctctatttga ataaagacct ggtctttgta tttttattgc tttttcttga cctgcttcta
    63121 aaatttcatt ttttacaact acaactgcat cttcaccatc tataaattga taggaataat
    63181 taaatttttg ttcaactaca tctttactat ttttatattt tatttctaat tttgagtgtc
    63241 cttcagtagt tacaaattta gctttccaat tttctgattc tccaataaag acatttttat
    63301 cattttttat attaagtata gctatcacag agattattaa aactataaga atacctataa
    63361 aaaatttttt cctcatatca atccctcctt tgaataatta taacatgaga atagttattc
    63421 aatactaatt ttaaaaatat tgtggattta tattctatta caatagaatg tctgttataa
    63481 caaataaaaa gtaaggatta atatgaatta taggttaaaa aaatctgtaa caactatttt
    63541 atctttactc ataatgacaa tactattacc aacaaatgca agtgctagta aggtagaaga
    63601 ttcatctatg aaagtaatgt attcagagaa acaagtaaca gacatggaca aattatacga
    63661 tatggctaaa aatggaatta ctgatgttaa aagttccaat gaaaaaggta taatcaaaaa
    63721 tgcaagaaca ggagagtcca tatacgttga ttctatatca acaactcaat tattagaagt
    63781 taaacaatct aaaaatttaa catcaaagat atattctaag acagtttttt tgatactaat
    63841 acaataaagc ctcttagaaa agcaagtata tcagaagatg gatgggataa aactggtggt
    63901 gtaaaagcat ctggtacagt tacatataca atatcaaaag gagatggagc atttcaatat
    63961 atttccgtta gtaaagtttc tggaaactgg tctattgcag acggccagat tcgtgtaaca
    64021 aatagaaggg tgcatataaa tcaaactgga tttatttcta atgagctagg aattaagcag
    64081 caacaaaaga aagagccaac atcaaattct ttctcatata atgcaccttc tagttggaaa
    64141 ccagtaggta gagattcagt tcaatacaat tgtgggtttg aattaattgc aacattagta
    64201 agaggaggaa gttcttgggc attcaatttc attgttcaac cttaaaatat tttaagtgaa
    64261 ttttattaaa atcaaagata tacatatact ttaaaattag agaatgtaaa ttaatttgtg
    64321 tttttaaaga taattcctat gttatagtaa caattgctta tttactatta atattt
//
LOCUS       DAEHWM010000009        64349 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.009, whole genome shotgun sequence.
ACCESSION   DAEHWM010000009 DAEHWM010000000
VERSION     DAEHWM010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 64349)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 64349)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..64349
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.009"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(359..871)
                     /locus_tag="KNP36_000620"
     CDS             complement(359..871)
                     /locus_tag="KNP36_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0872511.1"
                     /translation="MLEVIKNRRSIRTYIDKNIEEDKITEILKSAMQAPSSKNAQPWE
                     FIIVDDKELLKQLSKSQHRAKHIEFAPLCIVVLGNRDKFLKPGKWIQDLGACTQNLLL
                     EVTNQGLAACWAGVFPKNKVVNKVRQTLDLPLKLVPYALISIGYSEEKNEFIDRFDEN
                     KIHRNVYKNR"
     gene            1321..1797
                     /gene="purE"
                     /locus_tag="KNP36_000621"
     CDS             1321..1797
                     /gene="purE"
                     /locus_tag="KNP36_000621"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HBF0872512.1"
                     /translation="MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQL
                     SIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPVIGLPIKSSTMDGLDSLLSIVQM
                     PKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDNNLRG"
     gene            1803..2501
                     /locus_tag="KNP36_000622"
     CDS             1803..2501
                     /locus_tag="KNP36_000622"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HBF0872513.1"
                     /translation="MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGI
                     LNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKVEILPLEVIVRNIAAGSICKRVG
                     LEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA
                     FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDL
                     VEGYTEVLSRMNNK"
     gene            2513..3880
                     /gene="purF"
                     /locus_tag="KNP36_000623"
     CDS             2513..3880
                     /gene="purF"
                     /locus_tag="KNP36_000623"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HBF0872514.1"
                     /translation="MCGVLGIYSNKDVTKELYYSLYSMQHRGQESCGLALLDDGEIKY
                     KKDMGLVGDVFKENELSKLKGNIGIGHVRYSTAGGSHVSNCQPLVGSCRKRQLAIAHN
                     GNLVNANYLKDMLEEDGYMFQTNSDTEVILYILARYYKGDIVESLKVTMDYIKGAYAL
                     VIMSQEELVAVRDPHGFRPLVLGKKGDEYIFASENCAIDILGGEVIRDVEPGEIIVVK
                     GGELKSYFYSENYKPVKKSCIFEHIYFARNDATIDNVNAYEFRIKCGERLAQNETVKA
                     DMVVPVPDSGWPGAIGYANASGLKISEGLVKNRYVGRTFIKPTQEEREIAVKIKLNPL
                     STIIKGKSIILVDDSIVRGTTSKQLVKSLREAGAKEIHLRITSPPVAYSCYYGIDTPN
                     RSKLIASSNNVEEMREYIGCDSLKFLDIEGMLDATEHKSTFCKACFDGEYPVKKIDKE
                     ELLSC"
     gene            3874..4950
                     /locus_tag="KNP36_000624"
     CDS             3874..4950
                     /locus_tag="KNP36_000624"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HBF0872515.1"
                     /translation="MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLY
                     SLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTVGIDLVAMCVNDLICQGAKPLFF
                     LDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI
                     ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMERYVEELGMTVG
                     EALLTPTKIYVKLALDVLAKHDIKAVAHITGGGLIENITRVIPKGLGLDINKKSWEKP
                     PIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFINNRENDNADYVDKKY
                     SELLEDKAYIIGEVVDSHEGVELC"
     gene            4944..5537
                     /locus_tag="KNP36_000625"
     CDS             4944..5537
                     /locus_tag="KNP36_000625"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HBF0872516.1"
                     /translation="MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGL
                     ERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGYLKIISPKLVNEFRNKMINIHPS
                     LIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK
                     TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE"
     gene            5530..7062
                     /gene="purH"
                     /locus_tag="KNP36_000626"
     CDS             5530..7062
                     /gene="purH"
                     /locus_tag="KNP36_000626"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HBF0872517.1"
                     /translation="MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGV
                     NVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDKESHVETVNEHKIHSIDLVAVNL
                     YDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDT
                     MTLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQ
                     NGFLYSQSNAKNPILNYEQLGGKELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHAN
                     SCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKLNEIFLEIVVAYDFE
                     PEALEILKQKKNLRILKLAKIENSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKEKP
                     TDAQLKDMEFGMRVVKNMKSNAIAIVKNGQTLALGCGQTSRIWALKNALENNKDKDFT
                     GAVLASDAFFPFDDCVTLAHEYGISAVVQPGGSIKDKDSIEACDKYDMVMVFTGIRHF
                     KH"
     gene            7073..8323
                     /gene="purD"
                     /locus_tag="KNP36_000627"
     CDS             7073..8323
                     /gene="purD"
                     /locus_tag="KNP36_000627"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HBF0872518.1"
                     /translation="MKILVVGGGGREHAICWKLSKEKNVEKIYCAPGNAGIANVAECV
                     NIGDTNIEELLKFAKENEIGLTIVGPEVPLVMGIVDEFEKEGLRVFGPNKKCAQLEGS
                     KAFSKEFMIKHNIPTAKYKEYTNLEEAISEIDSFGYPVVIKADGLAAGKGVVIPENRE
                     DAIATLKEMMSDKKFGAAGDKIVIEEFLKGIETSILAFVDNDTIVPMASAKDHKKVNN
                     YEQGPNTGGMGTFSPSEIYTEELANKVKETVLEKTLEGFKKDGLNFKGILFVGLMITE
                     DGEKVLEYNVRFGDPETQSVLFRLETDLHEIMEAILDNKLKDIEINYSDDEAVCVMLT
                     SGGYPDSYEKGKIITGLENLDDDIVVFHSGTKMFDGNLVTNGGRVIGITAKSTTVKDA
                     AEKVYENIKKINFEGMHYRTDIGR"
     gene            8348..12154
                     /locus_tag="KNP36_000628"
     CDS             8348..12154
                     /locus_tag="KNP36_000628"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HBF0872519.1"
                     /translation="MLNTENKDSMVRRVLVEKREGFDLEAKALKKDLVESLHIDNIEN
                     LRILNRYDVEGISEEVYENAAKTIFSEPNLDVVYYEEIPKLNDERVFAIEFLPGQYDQ
                     RGDWAAQCVQIVNQGIRPAINTAKVYILSGKITDEEFSKIKDYCINPVDSREASLEKP
                     ETLKMETEIPTTVEVLDGFIDLDENGLKTFVSEKGLAMTLGDLQHVQKYFKDTEKRNP
                     TITEIKVLDTYWSDHCRHTTFMTEIENVKIEDGKFNDIVKEAYQMYLNSRDNVYVNRH
                     KDICLMDIATVAVKELKKNGKLNDLDESEEINACSINVDVEVDGKMEKYLVMFKNETH
                     NHPTEIEPFGGAATCLGGAIRDPLSGRSYVYQAMRVTGSADPRTTLEDTLPGKLMQRK
                     ITTEAAHGYSSYGNQIGLTTGQVAEVYDENFVAKRMEIGAVIAAAPKENVVRERPEAG
                     DVIVLLGGKTGRDGCGGATGSSKEHSEESILTCSAEVQKGDAPNERKIQRFFRNKEVA
                     QMIKRCNDFGAGGVCVAIGEIADSLDINLDLVPKKYDGLDGTELAISESQERMAVAIK
                     KENKDKFIQLAVEENLEATHVATVTDTGYLRMFWNGKAIVDINREFLDTNGVKQTTDV
                     HVTKVDEENTFFSSNEIVKDVKCASMKDKFTKVLSDLNVCSQKGLVEMFDNTIGGNTV
                     LMPFGGKYQATPTQGMVAKIPVLGGETNTSTIMTYGYNPKVGKWSPFHGALYAVVESV
                     CKLVAIGGNYSTTRLTFQEYFEKLGNNPEKWGKPFSALLGAFYAQSKFEIPAIGGKDS
                     MSGTFKDIEVPPTLVSFAVDTVDAKKVVSPEFKKADSKVVMLCVNKAENDVVDFEELK
                     RNLDKVRELIHGNKVLSTYALGFAGVGEAISKMAFGNKIGFKFSEEAEKAFTDDKLFE
                     ASYGNIVLELANDDLSMLEGYNYVVLGSTVKETSIFIKGEELALDELYKAHCSTLEPI
                     FPTKTEEVKSKIETISYISQGEAKKSSLSIATPRVFIPAFPGTNCEYDSARAFERAGA
                     NASIRVFKNLTYKDIEDSIDTIVNEIKSSQIIMLPGGFSAGDEPDGSGKFIATVFRNP
                     RVQEAINEFLTQKDGLMLGICNGFQVLIKLGLVPYGEIRVPSESAPTLTYNNIGRHQA
                     KIARTRISSNKSPWLAQTNVGDIHNIAISHGEGKFVASEDVMRELIANGQVATQYVDF
                     NNEATYDIEFNPNGSFYAVEGITSADGRVFGKMGHSERIGEEVYKNIIGEKDQKIFES
                     GVKYFR"
     gene            12360..13232
                     /gene="rfbD"
                     /locus_tag="KNP36_000629"
     CDS             12360..13232
                     /gene="rfbD"
                     /locus_tag="KNP36_000629"
                     /EC_number="1.1.1.133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="HBF0872520.1"
                     /translation="MKILITGSNGQLGKELVNQLEAINQSINQPKYVILATTRSDLDI
                     SNQTNVDNFILHNKPDVVVNCAAYTKVDACEDNIEIAYKINALGVRNLAIASEKVNAK
                     LIHISTDYVFNGFSKYPYREDNKTEPNSVYGKSKLMGEKFVEQFSHKYFILRTAWLYG
                     NGNNFVKTMIKLSLENKEVNVVNDQFGTPTSTVDLAKIIIKIMETEHYGVYHATCEGE
                     CSWYDFAKKIFKLKNIDIKVNPIKSNEFKCKAPRPLYSVLDNFMLKLIGLNSFRKWEE
                     SIEEYLERYDINEK"
     gene            13341..14210
                     /gene="rfbA"
                     /locus_tag="KNP36_000630"
     CDS             13341..14210
                     /gene="rfbA"
                     /locus_tag="KNP36_000630"
                     /EC_number="2.7.7.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="HBF0872521.1"
                     /translation="MKGIILAGGSGTRLYPITKCISKQTLPIYDKPMIYYPMSVLMLA
                     GIQDILIISTPRDIKAFEELFGDGSSLGLNITYAIQEKANGIAEAFIIGEEFIGNDRV
                     SLVLGDNIFYGYGFSERLENAVKRKGATIFGYHVSNPNSFGVVEFDKDFNVLSIEEKP
                     TVPKSNYAIPGLYFYDNDVVEIAKLVEPSDRGELEITSINSEYLKRGKLKVELLGRGM
                     AWLDTGTHKGLLDASNYVEVVQTRQGLYIACLEEIAYTKGYISREQLMKLAKPLIKTE
                     YGQYLLKLASEDM"
     gene            14259..14816
                     /gene="rfbC"
                     /locus_tag="KNP36_000631"
     CDS             14259..14816
                     /gene="rfbC"
                     /locus_tag="KNP36_000631"
                     /EC_number="5.1.3.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="HBF0872522.1"
                     /translation="MGKINVIKTKIEGLYIVEPNVFYDERGYFMESYNKKDFIEQGLD
                     MCFIQDNESSSRKGVLRGMHFQVKYPQGKLVRVTEGEVFDVAVDLRKDSQTFGKWEGV
                     ILSDKNKKQFYIPEGFAHGFLVLSEKAVFSYKCTNYYYPEFENGFIWNDKQISIEWPL
                     KGIEEIFLSEKDKKQKSFKDICTRR"
     gene            14854..15837
                     /gene="rfbB"
                     /locus_tag="KNP36_000632"
     CDS             14854..15837
                     /gene="rfbB"
                     /locus_tag="KNP36_000632"
                     /EC_number="4.2.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="HBF0872523.1"
                     /translation="MKKILITGGAGFIGSNFIHYMLNKYVDYFIVNLDLLTYAGNLET
                     LIEIQDNSNYKFVKGDISNREQVYKLFEEERFDIVVNFAAESHVDRSVENPDLFIKTN
                     IIGTQVLLDASIKYGVKRYHQISTDEVYGDLPIDRKDLFFTEQSSINPSSPYSASKAS
                     ADLLVSSYYRTYGLLTTISRCSNNYGPYHFPEKLIPLMILNALENKQLPVYGNGENVR
                     DWLHVYDHCTAIDLIIHKGNIGEIYNIGGHNERSNLEVVKMILNLLGKSEELISYVND
                     RPGHDLRYAIDATKIENELGWKAKYDFDLGIKETVKWYIENESWWKAVLSV"
     gene            15867..16535
                     /locus_tag="KNP36_000633"
     CDS             15867..16535
                     /locus_tag="KNP36_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing
                     protein"
                     /protein_id="HBF0872524.1"
                     /translation="MNEISSLINILALTQLSGSNTTNQCNCTYNNSSGFDMIMMTLLK
                     ALSQNNQHTSNSYNLLSNSENLFNELDNVVNNTTSRFIDVDTKDKNVKLRIENAVNQA
                     SKKYNVDSNLIKAIIKVESDFNPNTVSSAGAKGLMQLMPENCRDLGVTDPFNIEQNID
                     AGTRHIKEYIDMFGGSIEMGLMAYNGGPGRMKSRGVESISDLYKMPKETQNYIPKVMK
                     YYRG"
     gene            16544..16972
                     /locus_tag="KNP36_000634"
     CDS             16544..16972
                     /locus_tag="KNP36_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YaaR family protein"
                     /protein_id="HBF0872525.1"
                     /translation="MGINIDKLNISPSINMEVKKLKESNKFSDKLNSLKQSSSLEDIK
                     RNLESVKKAGERLVLTQNYGDISIYKNAVKEYLKSVVDNMYSLDKNSSFWEHQYYKNV
                     KIVDSKLEDMTSKLISEEKENIDIVSTVDMIQGLLIDMYR"
     gene            16996..17310
                     /locus_tag="KNP36_000635"
     CDS             16996..17310
                     /locus_tag="KNP36_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBF0872526.1"
                     /translation="MNSKKEDIYELNFGQLIEEKSGVIEENQNVFNAKVKVAVSIGNT
                     TETIKNILDLKEGSIIKLSKNVDEKLDIYANDRLFAYGESIITNEKLSVRLSKIEDSD
                     VN"
     gene            17461..17736
                     /gene="flgM"
                     /locus_tag="KNP36_000636"
     CDS             17461..17736
                     /gene="flgM"
                     /locus_tag="KNP36_000636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis anti-sigma factor FlgM"
                     /protein_id="HBF0872527.1"
                     /translation="MDIKNVSSNIVVNNYLKNTSGIKKVEEVKKINKTDKIELSKFAK
                     EMASVSNMSDENIRNKKVDEIKNALENGTYKIKPKEIAKKMIEDMRG"
     gene            17741..18157
                     /locus_tag="KNP36_000637"
     CDS             17741..18157
                     /locus_tag="KNP36_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FlgN"
                     /protein_id="HBF0872528.1"
                     /translation="MITDLKVIIYEEKNIISKMMELLKEQFDYIVEKDLENLNMLNPK
                     LEDISRELASIEIKRRQLFGNDISMSEVVENSNDGYLKEIYTDLKRILALAKNQQESN
                     DSLIKKELIFTKKMINFIKPADKQTTTYNSYGNIRK"
     gene            18175..19485
                     /gene="flgK"
                     /locus_tag="KNP36_000638"
     CDS             18175..19485
                     /gene="flgK"
                     /locus_tag="KNP36_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-associated protein FlgK"
                     /protein_id="HBF0872529.1"
                     /translation="MAGLFSILNTANSGMNAHQKAIQTISHNISNLDTDGYSRQRTEF
                     ATNSPMYMPSLSNSIARGQLGTGVHVTDVTRARNSFYDYQFRAEAHKYGKTVSKYDYY
                     NTIETILNEPSDYGISAGIDDFFKGWESLSKDINSDSKKSLVVENASNLATLISESYK
                     KLDKLKEDIDSNIDTEIKQINDMLKSLEDLNKSIDIISGSGSTPNDLLDERDRILDNL
                     SFKLDFENSDVKNMLADGKLELNELKNPDGTWKTGISGTLQGLFEMHGKIDTYKSDLK
                     DVSDGLAKQINDVYNTSAGITVTDFFITSNVDGEDIIKINPAIKSNPNELKLTADEAS
                     KIAKLKDEKIDIGVAGGKVSTISDHYKAFAESIGLDSQKVNQDEANQRKIINNIDNSR
                     MSVSGVSLDEEMTELIKIQRSYQASAKVMSTAVQLLDVVINGII"
     gene            19504..20436
                     /gene="flgL"
                     /locus_tag="KNP36_000639"
     CDS             19504..20436
                     /gene="flgL"
                     /locus_tag="KNP36_000639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-associated protein FlgL"
                     /protein_id="HBF0872530.1"
                     /translation="MRVSTGMMSSSYLNSLQDNLQRLDKVNRQVNTTKEINKLSDNPY
                     KAIKILNSKSEIKTMETYVENCKDTGNWLETTDTALDQLGKLLSDIKKTLVASGDGAY
                     SDDELKTLSNETNEKMKEIANALNATHEGKYIFSGSNTGVPPVECIDNADGSVSLKFN
                     SSLNLNKLNDSLSMDIAQGISVDYNVKLSSLGFDPTKTDPFEELNNISKKLANPDADA
                     IKELTTTCLGDMEQLIENTVNVRSIYGTKANTVEAMKEKNDDSLIQLKDILSQNEEID
                     YGEKLVQLKAAELTYQASLQTGGKLFNVSILDYI"
     gene            20452..20844
                     /locus_tag="KNP36_000640"
     CDS             20452..20844
                     /locus_tag="KNP36_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar assembly protein FliW"
                     /protein_id="HBF0872531.1"
                     /translation="MMKVTLKKGILGFENLKEYELLDIEDNDYLKEFNSTEEEGIGFV
                     VVSPFEIINEYEIVLNQETIEKLEVKSPKDVVLFNIITLGQTFEESTVNMKAPIVINI
                     KTNFGMQIILQDDKYSIRHPLLRGDNGC"
     gene            20838..21050
                     /gene="csrA"
                     /locus_tag="KNP36_000641"
     CDS             20838..21050
                     /gene="csrA"
                     /locus_tag="KNP36_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon storage regulator CsrA"
                     /protein_id="HBF0872532.1"
                     /translation="MLVISRKKDEAVLIGESIEVKIVGVDGNNVKLAISAPNNISILR
                     KEIYEKVKSENIKATNKNIKILKSLK"
     gene            21072..21467
                     /gene="fliS"
                     /locus_tag="KNP36_000642"
     CDS             21072..21467
                     /gene="fliS"
                     /locus_tag="KNP36_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export chaperone FliS"
                     /protein_id="HBF0872533.1"
                     /translation="MYGENPYNSYKQNAVFMASKEQLLLMLVDGAVKYTKIARAAILD
                     KNTQKAHRELVRVQDIFTELMVTLDQNAGQWAKDMYKVYDFVRYELSRANIRKDIQVI
                     DNVLPVIEQIKDTWHEADKKSKEERSRYK"
     gene            21467..21823
                     /gene="fliS"
                     /locus_tag="KNP36_000643"
     CDS             21467..21823
                     /gene="fliS"
                     /locus_tag="KNP36_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export chaperone FliS"
                     /protein_id="HBF0872534.1"
                     /translation="MELNLAELDKLSKEELLLMLVDGTVKYTNISKEALLNNDYLKAH
                     NELVRVQNIFTELMTTLDQNAGQWAKDMYKVYEFIKSELAIADENKDIKIIDDILPIV
                     KQIRDTWHEVYNQLKI"
     gene            21844..23367
                     /gene="fliD"
                     /locus_tag="KNP36_000644"
     CDS             21844..23367
                     /gene="fliD"
                     /locus_tag="KNP36_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar filament capping protein FliD"
                     /protein_id="HBF0872535.1"
                     /translation="MSSISPIRVTGLSGNFDMEGIIEASMIRDKEKVDKAKQEQQIVK
                     WKQEIYRNVIQESKDLYDKYLSINSPNSIVSEKAYSSTRITSSDESIIVAKGSAGAEK
                     INYQFAVSQMAEPAKFTIKLNSSEPIVRQFPPNASGASSLTIGDVNIPISEQDTTSTI
                     VSKINSLCADNDIKASYSEMTGELIISRKQTGSSSDINLRVIGNDNLAQQIANDNGIT
                     FINDAGGNKVANVYGKNLEADVTDEHGRVTHISKEQNSFNIDNIDYNVNSKGTAKLTS
                     VTDTEEAVKNMQAFVDDYNKLMDKVYGLVTTKKPKDYPPLTDAQKEDMTTEEIEKWEK
                     KAKEGILRNDDELRGFVEDIQSAFFGDGKNIIALRKLGINESENYNKKGQISFNADTF
                     SKALIDDSDKVYKTLAGYSSNYDDKGMFEKLKDIVYEYSGSSTSKLPKKAGIEKTASA
                     SENVYSKQIAEQERNISRLVEKMNDKEKRLYAKYSALESLLNQYSSQMNYFSQAQGN"
     gene            23370..23705
                     /gene="fliT"
                     /locus_tag="KNP36_000645"
     CDS             23370..23705
                     /gene="fliT"
                     /locus_tag="KNP36_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FliT"
                     /protein_id="HBF0872536.1"
                     /translation="MDKLKEKLNLYKDISLQIINLIEKEEYIKISIKLGERQEIINSV
                     SEIDRNDFIQLYNRMELIEIDSRIRDILQGQLLEVKKELHEYKLTKQVNTMYYNLNRE
                     KVNIFNKKV"
     gene            23807..24679
                     /locus_tag="KNP36_000646"
     CDS             23807..24679
                     /locus_tag="KNP36_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellin"
                     /protein_id="HBF0872537.1"
                     /translation="MRVNTNVSALIANNQMGRNVNAQSKSMEKLSSGVRIKRAADDAA
                     GLAISEKMRAQIKGLDQAGRNVQDGISVVQTAEGALEETGNILQRMRTLSVQSSNETN
                     TAEERQKIADELLQLKDEVERISSSIEFNGKKLLDGSSTEIRLQVGANFGTNVAGTSN
                     NNNEIKVALVNTSSIMSKAGITSSTIASLNADGTSGTNAAKQMVSSLDVALKELNTSR
                     AKLGAQQNRLESTQNNLNNTIENVTAAESRIRDTDVASEMVNLSKMNILVQASQSMLA
                     QANQQPQGVLQLLG"
     gene            24772..26913
                     /locus_tag="KNP36_000647"
     CDS             24772..26913
                     /locus_tag="KNP36_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBF0872538.1"
                     /translation="MLLSIVMIVKNEEKILEKTLKSLTTLRNSIESELIIVDTGSTDD
                     TIKISKKYTEKVYFHNWNNDFSSMRNISISYAKGEWLLILDADEILIDSSTIVKFFKD
                     GLDKKFNSASIQLKNLYSYDKKLYGYCSVLRLFKNVDFRYHGKVHEQPIYKNPIFNNV
                     ADFEHYGYLFEDEEIRLNKVKRNEKLLFQELKENDNSPYTNYQLGKNFIILGKYQEAL
                     YYLEKSYELYSKLELAPGYLITSLVKTYLYLGKHKKCERLCLKYIKKDMNNIDIYYYI
                     AQAQVDLGKYENSIDSYKRYIYLLDNYEISTQANSLFSDTDTVGLRDEAIITLIKIYY
                     KLEKYEFVISEYNNIEDVEKKKNVYFSLFMSLYKLNRFEDIKNYYKEVSNSKIEKNSF
                     YRNIEEVINNIKEDEKEYVYKILCDIEGNYGILNQIRINKCVSIDKCKEILNEEKEII
                     YAYIIKIAFEEKIDLLDIFYEMEYVWIEKYLKYLLALERSFNLVLYKYIISRPNTSDM
                     EKIRVYKAISKVVLESISLSDEKYKEIFYLYIMYSYKYIRYIYSNLSDFELIKFVCND
                     LDKFTIEFKHLLDIKNKVNNANEKLEYIHSMRKLLNEYPFYNKIIKILIGELEENIKE
                     SEEFKDLKDSFIISIENMIETGKINDAKLLVDDYSKTFVDDIKILNIKGILYMFENKL
                     DKADFMLKKALSLDVENEDTIYNIEYLKSLR"
     gene            26937..28814
                     /locus_tag="KNP36_000648"
     CDS             26937..28814
                     /locus_tag="KNP36_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBF0872539.1"
                     /translation="MNIPIVVNEKSKDIIKDWQYTCTNEDIKFTSIIILTYNQIEYTK
                     LCIESIRKFTPKNKYEIIIIDNNSSDGTVEWLKGQSDIKSVYNNKNLGFPKGCNQGIE
                     LATGENILLLNNDVIVTPNWLYNLNKALWSQDNIGAVGPITNACSYYQQIDVDYKSIE
                     DMFIFAHKINKSNINLWKYRLKLVGFCMLIKKTVLDNVGVLDELFTPGNFEDDDLSFR
                     MIESGYKLLLCQDTFIHHFGSVSFKENRNKYTDIMYINRRKFETKWGFNPEYSGMIRT
                     DLISKIDDSLEANINVLEIGCGIGATLLEIKNIYKNASIYGIEISESAGKLAKYSADV
                     LIANIEKVKLDYKKDFFDYIILGDVLEHLIDPWKIVNELKQYLKKDGYLVSSIPNIMH
                     VSVLRNLVLGNFTYEDSGILDKTHLRFFTLNEITKMFNDSNYIINSITATSMPLSEID
                     NSFIDTICKESCKEMRQQYESYQYIVKASKILDTKRYSSISMINLKYALMRIDNELDV
                     DSNLSYIFDNYNITEPCFVDDIEYLIDTFVINKATLLNRLGVEAFNRGLGDFSINMFM
                     TVLEMDRDDIDSIYNITSVLCELEEFDTAYNLIKNSSEKVQSESDIQEILCFIEGKKY
                     E"
     gene            28807..30921
                     /locus_tag="KNP36_000649"
     CDS             28807..30921
                     /locus_tag="KNP36_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBF0872540.1"
                     /translation="MNNDKICFITCVNDERLYEECLVYINSLDIPKNFSIETVALRGA
                     DSIASAYNKAMRETDSKYKVYLHQDTFIINKNFIHDILEIFKKNTDVGMIGVAGVKDM
                     PVNGIWWDSDKKAGKVYDSHTGKMDIYEFSNFEECFNEVMAIDGLIMITQYDVFWRED
                     KFDGWHFYDLSQSMEFRQNKYKVIVPKQNKPWCMHDSGVVNINNGYDEYRIKFVKEYI
                     NLDLYRENFYEFDKKKASTILKSNKHVMDCMKEELTEQLRLKNYKDVLGIVSKIAHFS
                     VFNHTGLYSCEECERALLECANNLPEIENTKLFTKKDLKRRKVLHVLSEGYSTGGHTR
                     LVKNWIEIDKDSVHSVVTTWQSDTLPDWLLKAINDSGGEVISLDLISDDYLKRAVALR
                     KIAYDWADIVILYVHMWDTIPVVAFGVDGKIPILHVNHYDSTFWLGTSIADIVIDFSE
                     ASQLITLDKRGIDKSEILPMPLKEKEVFSKSEVRKRYNLEDDVTIILTIASERKYNSV
                     NDINYFKIAKTLIENTDNTIIIVVGVDTENLYWKTLSNVTDNRVICFGTTANIDDFYK
                     ISDIYMESFMVGSHTSKLDAILYDLIPVKFKNEVSPIFTNMWNFIDKFDYKNIKEVID
                     MIKRYNTSEFDRDRIKEKQSEIKHFVIDKHCIEIKNYIDKIYNEANHHKVKYDLYKND
                     EIEDYQLFVALYGYMVKNKNMS"
     gene            30930..31925
                     /locus_tag="KNP36_000650"
     CDS             30930..31925
                     /locus_tag="KNP36_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation glycyltransferase
                     FemA/FemB family protein"
                     /protein_id="HBF0872541.1"
                     /translation="MNNIHINKFEKSCERNWDYFVENKSINGTFLQTRNFLNYHEEGK
                     FTDHSLIICKGEEILAVVPACETYEDGERIFFSHLGSTFGGIIIRSGFNDIRHVNAIT
                     NKLEIYLREQNFDKVYLKNTSRIFCKEDTSLLEYFLFKNNYMFYDELSMFLELSKYKE
                     DILANFKYSKRRDFKYSLKNNLTFKRLYSDEDIVCFFNLLSNCLDSKGAKVIHSVEEL
                     LEFKNNRLKDIVEFYAVYIDDIMICGSMVFNFQERVYHTQYLASNSTYNKYYPMIFLY
                     YNLIKDALERNFKYLSFGISTLNRGKYLDEGLATFKEGFGSSAICNRTYYKNINK"
     gene            32017..33249
                     /locus_tag="KNP36_000651"
     CDS             32017..33249
                     /locus_tag="KNP36_000651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HBF0872542.1"
                     /translation="MKRLMILGSIKYFENIVISAKKEGIYTIVCDNRIDTPAKKICDE
                     AIDVDVFDFDKIKSIAIDKKIDGILTGFTDSLMKPYVYIANELNLPCVISCNQLESVT
                     NKAIMKKYFKNNAIPTTDYCIIESLKDLEKIQGLNFPLVIKPVDGYGSRGVYFVSNIE
                     ELIEKFEYSKEASQDGQVIIEEFYESEEIQGLAWVHNGESHVFYIGDRELVNIHTGRA
                     GKPDRLLYPSKYCFQYEEEIKSIYQNITQAFDIKNGPLYVQMLVGAYGIKVSEVMPRL
                     PGGCDYMAISQITDLDIGSLFANFSVNNEVNFDEIKKYNMHLSKCVYALPIYIRPGTI
                     KKINNIDKIENLDYVTQFLLLVKEGDTIELYEDERQDCGRVYGIANNIFDANIKKKCI
                     HEMIEILDENNENMIENF"
     gene            33269..34213
                     /locus_tag="KNP36_000652"
     CDS             33269..34213
                     /locus_tag="KNP36_000652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase"
                     /protein_id="HBF0872543.1"
                     /translation="MKLITHEQIMSLNISQKQGYEWIKESFLTKKDCQLPPKISMVEE
                     GHVFYNVMPSLNHNHMIGGIKMVTRLPGRNPSLNSEIFLYNMEDAKLKAILDGNYITA
                     FRTAAVAALAIDTFAKKDFNTIAIMGLGVTASAIMNMLSYTLKDKNINIKLLKYKDQA
                     ELFVKKYEKNEQFSFEICDTHEELIVDSDVVISTVTYTDEYLSEFKWFKKGALLLPVH
                     VMGFGNVDYLFDKVYLDDYNHLKHLENIDRYKYSCEFYDVLSKQAKGRENDDERIISY
                     NIGLSIHDILFANKIYELCETLSCEEIELKEPKEKYWI"
     gene            34307..34714
                     /locus_tag="KNP36_000653"
     CDS             34307..34714
                     /locus_tag="KNP36_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WxcM-like domain-containing protein"
                     /protein_id="HBF0872544.1"
                     /translation="MDKYNLIRFVSIGNEYIGNLVALESNKVIPFDIKRVYYIYDVPN
                     NVKRGFHAHKNLEQVLVCLNGSVKIKCYDGVKETIFNLHKNDVGLYIGTGVWHEMFDF
                     DEKTVLISIASEHYNEEDYIRDYKEFLKYLNNV"
     gene            34801..35892
                     /locus_tag="KNP36_000654"
     CDS             34801..35892
                     /locus_tag="KNP36_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="HBF0872545.1"
                     /translation="MLVKFNNLLKQFQTHKEEYEQKIKDVMESGYYILGNEVKHFEEE
                     FANYVGSKYCVGLASGLDALIIAFRALGISKGDEVIVQSNTYIASVMGISINGATPVF
                     VEPNEYYNIDSSKIEEKINSKTKAILVVHLYGQASNMKDIQELCDKYNLYLIEDCAQS
                     HGAKYDGKMTGTFGDIGCFSFYPSKNLGAFGDAGAIVTSNEEIADKVKILRNYGSEKR
                     YYNKFVGYNSRLDEIQAGLLRVKLKYLNEIEIEKSKIVDRYLNEINNPKVILPKIENN
                     CTHVWHLFVLQVEKRDTFMEYLKKSGIESIIHYPIPPHLSEAYAYLGYKKGSFNIAEN
                     YSDKVVSIPLFIGMEDEEVSYIIKIINEY"
     regulatory      36201..36291
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            36700..37017
                     /gene="flgB"
                     /locus_tag="KNP36_000655"
     CDS             36700..37017
                     /gene="flgB"
                     /locus_tag="KNP36_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgB"
                     /protein_id="HBF0872546.1"
                     /translation="MNTYDIIKMGLDATNLRSQTIANNIANINTEGYKRHYITFEETL
                     NDAMPKIEEKTDNSKGLRVDGNNVDIEEEKVNQAMATLQYNALISFANGKIAMTKSII
                     SGR"
     gene            37025..37429
                     /gene="flgC"
                     /locus_tag="KNP36_000656"
     CDS             37025..37429
                     /gene="flgC"
                     /locus_tag="KNP36_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgC"
                     /protein_id="HBF0872547.1"
                     /translation="MSVFSGMRISASGLTAESLKMDIISSNVANINATRGPNGEAYRR
                     KVVSFEENYDNKLGMLGVKVTSVEDDKSPLKEVYDPSHPDAKPNGYVEYPNVNILVEM
                     TDLITASRAYDSNVDTLNAQKSMISKALEIGK"
     gene            37439..37756
                     /gene="fliE"
                     /locus_tag="KNP36_000657"
     CDS             37439..37756
                     /gene="fliE"
                     /locus_tag="KNP36_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-basal body complex protein FliE"
                     /protein_id="HBF0872548.1"
                     /translation="MPITQINNLMQGAKLDNLIGEAKPLTLNNKEEKKNFEDVIIDTI
                     DKVNFQQVTADDMKEKFIKGEDVSMHEVMLIGQEAQLSMQYLIEVRNKIHDAYQEMNK
                     VQI"
     gene            37781..39331
                     /gene="fliF"
                     /locus_tag="KNP36_000658"
     CDS             37781..39331
                     /gene="fliF"
                     /locus_tag="KNP36_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar M-ring protein FliF"
                     /protein_id="HBF0872549.1"
                     /translation="MITSFKNKIKEQVAKSRTKISSLKKGTKIALGIGVIAICLALVF
                     TAISASKNKYAVLFSELDAQDAADISAELESKKIDTKVKGSTIYVPRTEVDKLRLELA
                     PSLTGGSKGFALMDDSSSIGLTDEEFQIKKQRMIQGEIEKTIKSFPQVEDTRVHITFG
                     ESSVFEKEAVPGSAAVYLMLKPGTTLEKNQIKSVMALISGSVTNIPEKNVQVIDNKMN
                     LLSEGILEDENVDENNQPINSGISVDKNKASEQALNKQLEKSILEMLEPIFGKGKVKA
                     TVNADLSFDTAEKTEIKIDPDKVAIKETRSKNSSKSAANNVQGVDANMNNQGNNNGTN
                     TEDSLDESFEYETGKIETHTIVAPGELNRLTASVAIDGKIAKGVQADVEDIVNNAIGM
                     DGARGDTLSVVSMVFDPEGKKEAKQELEEIKKEGFKKNIIKAVIGVVAVIAVGAIGYL
                     IYKKRSEREDMDYEDEDYISKSDSVDRKDNPLLGDDPELTLEEAVKMYAEEKPDQVTE
                     IIKTWLNE"
     gene            39344..40414
                     /gene="fliG"
                     /locus_tag="KNP36_000659"
     CDS             39344..40414
                     /gene="fliG"
                     /locus_tag="KNP36_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar motor switch protein FliG"
                     /protein_id="HBF0872550.1"
                     /translation="MSTEITNVNAFDLSDINESDKNEKVEGEGLKKAAVLLMTLGPNV
                     SSDIIKSLPDKQVQKIGLEIANISSIASKERREILKEFVEINRAKDYVIEGGLEYARE
                     LLSNALGNVKANKLLEGISINTSTKPFKHIIKLDVKKILEILRNESAQTIAVLLAHME
                     PENGAEVLSYLDFDLQNEVAMRISSMGSISPEVIKVIESSLEDKLHSISGDDFNDYGG
                     VSTLVQILINSDRKTEKNILGTIEEQNPDLAAQIKSHIFVFEDIVKLDDISIQKVLKE
                     VTMKDLVYALKGVDDEISDAIYRNQSSRAADALKEEMEMVGVIKVTQVEASQQKIANI
                     VRKLEREGAITIVRNFGGDFVE"
     gene            40407..41138
                     /locus_tag="KNP36_000660"
     CDS             40407..41138
                     /locus_tag="KNP36_000660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar assembly protein FliH"
                     /protein_id="HBF0872551.1"
                     /translation="MNNKIIKSKKALYKGVLDLTIIDKVRVGESNVNKENDCRFRDEV
                     IKEAIESAEIRKNEILEEAKMNAQNIEKQAYEKGYSQGQKNGYEDGYKESYDEYTQKA
                     KDEADFIKNQADLILLQANEKMTEYIKEKNKEIVRLAINMASSVLKKHFEDEESMSDL
                     LKQIIQDYEGSSSFIVRCNSFYKDNIEKEFELFKEETSLKSSVFVIADDSIDKGNAII
                     QKENGRIIVGIDCAMEKLKEELLGE"
     gene            41142..42461
                     /gene="fliI"
                     /locus_tag="KNP36_000661"
     CDS             41142..42461
                     /gene="fliI"
                     /locus_tag="KNP36_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein export ATPase FliI"
                     /protein_id="HBF0872552.1"
                     /translation="MYKTDISIDFDKINKKIENLELTISEGRVKKIIGLTVEVEGIKA
                     FVGELCVIYNQVNKPVNCEVVGFKDKEVILMALGELTLIAPGCKVISKGIPLSVMCSD
                     NLLGKVLDGLGNPIDNSDAVLGDRYNLNNEPPDPMKRKKIRNIMETGVRAIDAFTTCG
                     EGQRIGIFAGSGVGKSTTLGMIARNAKADVNVIALIGERGREVLDFIDKDLGEEGMKK
                     SVVVCATSDKAPLVRLKGALTATAIAEYFRDQGKKVILMMDSVTRFAMAQREVGVAIG
                     EPPAQKGYTPSVFAMLPKLMERTGTSDKGSITAFYTVLVDGDDFNEPIADTTRGILDG
                     HIVLSRDLANKNHYPSIDVLNSLSRLMNEIASKEDIKIASFARDMLAEYREAEDLINI
                     GAYASGTNKKIDEAIYYHEHIINFLKQGINEKSSFNETISSLRRIFE"
     gene            42493..42939
                     /gene="fliJ"
                     /locus_tag="KNP36_000662"
     CDS             42493..42939
                     /gene="fliJ"
                     /locus_tag="KNP36_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012815984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar export protein FliJ"
                     /protein_id="HBF0872553.1"
                     /translation="MELDKNFKFRLQKVLDLKIKDEEEIKMEFAKIQQKKIDIETNLE
                     NLESNYSKYSISKNNDNVQNQKITINYLLALNNSIMDLSEELDKSTNELEKARKQLIS
                     KQIERKSLEKLKEKKYGQYYKEEQLKEQSTNDEFASMSYLRNRQVL"
     gene            42967..44172
                     /locus_tag="KNP36_000663"
     CDS             42967..44172
                     /locus_tag="KNP36_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-length control protein FliK"
                     /protein_id="HBF0872554.1"
                     /translation="MKIQADSYNIIKDIGNRKNSSKNKNIKNNKFEDNLYKTTDHKNV
                     KDRRETSKQNVSSDRPGNSDNECHLDEDKSNHLEDENTYEKDCSKNNEALQQLLNLLK
                     ENYKKDKDINTILNNIKKLSISDELKQELKLNKNILNKIANQNLELNGANTNNPNDIE
                     NLDIMKLRELLENNASEDIQVISKTTENDTKSIDLYSFDSNRMDTLNSNKQKDDSSDI
                     LEKLAGLNGNKSGNFGQVINKSVDMNKIKNDNVNLKQIESNVMDDSIKAIKHMKTNDI
                     QELTIKLRPKELGDMNIQLLKDGESMRAVVTVFNKDVFDSINKNIADLKQHLELTNVN
                     IKDVSVQMHSDNTNTSDTFDKAFEQQNRQNNQENMSNQNTNDKRNNVVIEDEIKENII
                     DDDRVDLLA"
     gene            44190..44798
                     /locus_tag="KNP36_000664"
     CDS             44190..44798
                     /locus_tag="KNP36_000664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlgD"
                     /protein_id="HBF0872555.1"
                     /translation="MYGIATALAGTQVNYRSNNLSQLERNINDIANKQVRSKGNQTVT
                     DNGTPIIGQGDDADKDLFMKILVAQMGNQDPMNPQDPTEYVSQLAQFATLEKMSAMND
                     KLDILLALSNSTLINSALSMATSLIGKEVEVSGEEDEDENIVGVVKSTYIKDGEVHLE
                     LEVDGSDKTVDVKYEKLLKIGEVEANSGEENDSSEQESPEEV"
     gene            44825..45808
                     /locus_tag="KNP36_000665"
     CDS             44825..45808
                     /locus_tag="KNP36_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar hook-basal body complex protein"
                     /protein_id="HBF0872556.1"
                     /translation="MIKAMYSGVSGMKANQTKLDVIGNNVANAGTTSFKKSSARITDS
                     FYQTVLYASAPTAALGGTNLGQVGVGSKISSINKDMTQGNVQPTNRPSDLMIDGDGYL
                     PVVRQGTVMYTRDGSFNLDTGFKAADGALKNIKGGRLVNGDGYMLQGMIYDGEYKADT
                     GEFVKKGDAKGKEPIVIPLQSISPKDGTVQNVLEYNISKDGTVEFLLSDGQRTQFVYD
                     IPDGAKVGDTPAGIDKLKGTIQKVQTYAFQNPAGLDAEGGNLFKPSANSGDPQIAGAT
                     GTIIQGAIEASNVDIAEEFTEMIIASRSFQANSKIISTSDEILQEIINLKR"
     gene            45821..46024
                     /locus_tag="KNP36_000666"
     CDS             45821..46024
                     /locus_tag="KNP36_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar FlbD family protein"
                     /protein_id="HBF0872557.1"
                     /translation="MIRVTDLNGRKYILNSDLIVRIDSVPESRILLTTGEKNLVKESV
                     DEIVDKVIKYKRKINVGYIRSEK"
     gene            46024..46842
                     /locus_tag="KNP36_000667"
     CDS             46024..46842
                     /locus_tag="KNP36_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MotA/TolQ/ExbB proton channel family protein"
                     /protein_id="HBF0872558.1"
                     /translation="MKKTDSLTFIGLILSTVLVLFGAVKGSSSGLKSFFDFASILITV
                     FGSFGALMITFTIDDIKLIKDALQYSFKTMNISKLDLLNQFKTLSKKARREGLLSIES
                     DVMKIQDPFMKKGLELCIDGLEINEIRSILELEIDSVEETNNRYSKLFKTWGTFAPAF
                     GMLGTLIGLIQMLSDLTSPDLIASGMGKALITTFYGSLLANIALNPIAYNIDEKTEKE
                     IYVKEMMLEGIISIQSGESSIVVEERLATYLSNNEKLEIMKSNKNTERAMSNGA"
     gene            46832..47527
                     /locus_tag="KNP36_000668"
     CDS             46832..47527
                     /locus_tag="KNP36_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBF0872559.1"
                     /translation="MARKKNKKKDEINPDAWLATYADTITLILTFFVLLYATSVVDME
                     KFKNIADALKGQFSGTSMFSTGSSTSEKSPIESVLVDKNDKSNLEQDLKDKVNNSNLQ
                     NSVTVKDDSRGILLELDDSILFDSGISELKEDSKATLNKVYDMIKMMKNKIVIEGHTD
                     NVPVKSSTHESNWDLSSSRAVSVVRYFVEEKGMDPKLFSATGCGEYQPLVSNETAKGR
                     AENRRVNILITID"
     gene            47539..47982
                     /locus_tag="KNP36_000669"
     CDS             47539..47982
                     /locus_tag="KNP36_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body-associated FliL family
                     protein"
                     /protein_id="HBF0872560.1"
                     /translation="MFKNKKIIIIILILIIFSAGAGFFILGEGGNKQIDKIAGLFIPT
                     GKGKDEVKTENLDLEEMVLKLADEGVRYLKVSITVSYDSSYKDIEKNTPLIRDNIINC
                     FMAKRADDFTADNLKNIKEEIKNTLNIQLGENVIQNIYFTNIVVQ"
     gene            47997..48371
                     /locus_tag="KNP36_000670"
     CDS             47997..48371
                     /locus_tag="KNP36_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FliZ"
                     /protein_id="HBF0872561.1"
                     /translation="MILYLLKILICIPIILILIVLSLKISQGTLLKKYNDKYIKILDI
                     VNISKNNSIIILKIGEEGCIMASSSSSMSKIKDLTKEEILRIENDIKERNFKIQDFKM
                     ERIKKKYDFSRYIGKFTKKEDK"
     gene            48372..49037
                     /gene="fliP"
                     /locus_tag="KNP36_000671"
     CDS             48372..49037
                     /gene="fliP"
                     /locus_tag="KNP36_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425215.1"
                     /note="The bacterial flagellar biogenesis protein FliP
                     forms a type III secretion system (T3SS)-type pore
                     required for flagellar assembly; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar type III secretion system pore protein
                     FliP"
                     /protein_id="HBF0872562.1"
                     /translation="MELLSKLPLADVPYTSSMQLFLFLTALMFLPFVMFMMTSFVRIV
                     ISLSFLKSALGAQQAIPSQILVGLAIVLTIFIMRPVLNEINEKALQPYMKEEVTMEEA
                     MKEAEGPIKEFLLKQTRQTDLDLFVEQAGLKEKKLTRENIPLSVVVPAFAISELKTAF
                     QIGFLIYIPFLIIDLVVASVLMSMGMFMLPPVMISLPFKLLLFVMVDGWNLIVKTLIL
                     GFG"
     gene            49050..49319
                     /gene="fliQ"
                     /locus_tag="KNP36_000672"
     CDS             49050..49319
                     /gene="fliQ"
                     /locus_tag="KNP36_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FliQ"
                     /protein_id="HBF0872563.1"
                     /translation="MSEFMIMSVLKNGMFTGAMIAAPVLIVSLVVGLLISVFQATTQI
                     QEQTLTFVPKLIAILLVVAIGGSWMLHTLISFTSEIFNMMSLITK"
     gene            49331..51145
                     /locus_tag="KNP36_000673"
     CDS             49331..51145
                     /locus_tag="KNP36_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fused FliR family export protein/FlhB family
                     type III secretion system protein"
                     /protein_id="HBF0872564.1"
                     /translation="MIFVFIRIVAFFGTLRILFPAGTPALFKSLFAIIISILISSTMQ
                     IEYATNIDNIVLFTLYGINETITGIMLGYITNLCFYSIRMAGSMMDQQMGLSMINMFD
                     PNSMTQTTLINNLMNWTALMIFFSMDGHHVLIRGIRYSFELIPIGKSFIDNNIDYIIN
                     IFVQCFLTGFKIAIPIVLCLLMADFILGLISRSVPQLNVMIIGMPLKILVGIALFIIS
                     IPLIVNQISHLLSQIPKMYEGTFALAPMFFMGSTDKTEEATPKKKGEQRKKGNIAKSK
                     ELPIAMTLLAFTLLVPTLFSYVVNTLKSSLNYFLSLDFYMNINYSSIEKLVIAGLMDF
                     FKIFLPIAIPFLVLGIVANLFQVGILFTGETLKPNLSKLNPISGFKNMFSMRSLSTLI
                     KDTAIISILAYIGYTFFQDNYLDILKLGNIYLPTLMYTVKDLVYSILSKICVAMIVIA
                     VADYVYQRYSHKKQLRMTKQEVKDEYKNSEGDPEIKAKIKQKQRQISSQRTMQAVPSA
                     TVIVTNPTHLSIAVRYEKGKDQAPVVVAKGADYLAFKIREIAKGNDIPIIENKPIARL
                     LYKQVEIDQEIPEDMYQAFAEILVAVYKIKNRYKVPKR"
     gene            51154..53229
                     /gene="flhA"
                     /locus_tag="KNP36_000674"
     CDS             51154..53229
                     /gene="flhA"
                     /locus_tag="KNP36_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlhA"
                     /protein_id="HBF0872565.1"
                     /translation="MNKFNLKENMDVIVAFGVVGIVLMMIVPLPTFILDILLAINISL
                     SVLILLMTLFTTNVLDLSIFPTVLLVTTLFRLGLNLSSTRLILTQGYAGEVIEAFGSF
                     VVGGNYVVGIIIFLIILIVQFVVITNGSGRVSEVTARFTLDAMPGKQMSIDADLNAGV
                     IDDKTARKRRKELQQEADFYGSMDGANKFVKGDAIAGLIVTAINIIGGIVIGAVMLNM
                     TLMGAAQTYVRLTIGDGLVSQIPALLISTSAGIIVTRASTDENFGGLVGKQLTAIPKA
                     VMMTGCVLIVLGMMPGLPKPAFFSLGIGAIAAGYFLGREKKDTLEDLEFEKPDMVNPD
                     KNEVEDVTNLINVESIEVEIGYGLISLADESAGGDLLQRIASIRRQCAIDMGIVVQPI
                     RIRDNLQLNPNQYNIKIKGNVVGGYEIMPNMVLCMDPMNQGFSIFGIKTIEPTFGIEA
                     LWIESDKVEDAELKGYTVVDSSTILITHLLDIIKSNAHELLGRQEVKTIIDAARENYS
                     AVVDELIPDLMTLGEIQKVLKNLLREKVNIKDRVTILETLADQSRNTKDIELLTEYVR
                     IALARSICNNLVDEDKAIVVATLSPETEELVSNNLQRSVNGTYPAVDPENTNKIFESI
                     QEVMNNVYFNHNIPVIVVSPKIRAPFRKLVEIVYPNLTVLSLNEIPNDIKIKAEGVVS
                     IYDDEKVYS"
     gene            53204..54220
                     /gene="flhF"
                     /locus_tag="KNP36_000675"
     CDS             53204..54220
                     /gene="flhF"
                     /locus_tag="KNP36_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar biosynthesis protein FlhF"
                     /protein_id="HBF0872566.1"
                     /translation="MMTKKYTANTIQDAMNLAKMELGDNITLIDKKEVRKSGIRGIFS
                     KKDIELTIGWEKKDNLEQKDLKREIEQLKSIINNMGFDNKNDNDIDKICKNLLNLDLN
                     QEIVEFIKADLQEMKFNGIDTSKNLVESLKKKIKIENQAINGKIALVGPPGVGKTTTI
                     AKLAAKLVFEENKKVGVITIDTYRIGAVEQLKIYTDIMNIPFKGVISPDEMELALDEM
                     KDCDVVLIDTTGRGYKNSMQILEIKNLIDKAETDNIHLVLNCTTRESDTKAIIDSYRN
                     VNFKSLIITKLDETITYGSIFNIMNYAQKPISYITTGQNVPDDIIKPNEDKIIRLLLG
                     VESI"
     gene            54217..55095
                     /locus_tag="KNP36_000676"
     CDS             54217..55095
                     /locus_tag="KNP36_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MinD/ParA family protein"
                     /protein_id="HBF0872567.1"
                     /translation="MIDQAQILRKMAMEKRGSDEIIVENENMPKIITIASGKGGVGKS
                     NLATNLSICLTKLDKKVLILDADIGMSNIDIIMGVNVKGTIIDVINGEKNIEDIISQT
                     KYGVNIISGGSALNHIEDFTEAQRNKFIHSIEQIHNVDFIIIDTGAGMSKSLLSFIYC
                     STEFFLITTPEPTSLTDAYSLLKAISNFGIKKSANIIINRVIDLEEAKSTYKRIKMVV
                     DKFLNLNLELYGYIIDDKKVGVCVKKQIPFILEYPTSIASKCIIAIAKRMVSQSREDI
                     VDNKSFLRKMFSIFKS"
     gene            55109..55810
                     /locus_tag="KNP36_000677"
     CDS             55109..55810
                     /locus_tag="KNP36_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliA/WhiG family RNA polymerase sigma factor"
                     /protein_id="HBF0872568.1"
                     /translation="MNREELIKENMPLVKSIARKFFIPGKGFEYQDLVNSGVIGLIDA
                     INKFDTEKGAKFSSYSYIKIKSAILDEIRNQSPISKHNLTKVNKYNRVVEKLQSKLLR
                     EPTSYEIAKELKVSEKELHDIESNIDMLNIVSLNYVIFEDTNETVQDVISDREEEAPE
                     NIIEEEEKLEILSKAISNLNEREKLILSLYYYEDLNLKEIGKVLGVSESRVSQLHRKS
                     IRNLRNKIKELKYSI"
     gene            55826..56248
                     /locus_tag="KNP36_000678"
     CDS             55826..56248
                     /locus_tag="KNP36_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein"
                     /protein_id="HBF0872569.1"
                     /translation="MIQIILIVVSILIIVTIVINLQKESKNKDNRYFDKIFEQEYEAN
                     DRLIIAEKRRFFLDKVLAEKRINSHIKVYENYNLIKANEERKENIFIESKKEVRQENE
                     LSLKVKHLISSGYDDVEICKMLDIGKGELLLIRSCYKI"
     gene            56233..56418
                     /locus_tag="KNP36_000679"
     CDS             56233..56418
                     /locus_tag="KNP36_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein"
                     /protein_id="HBF0872570.1"
                     /translation="MLQNIRILLCDKKVFLGIGIGILISTLCIMLFSNNDMSKAEIEK
                     KARALGMKYTSEMKVLE"
     gene            56459..57232
                     /gene="flgG"
                     /locus_tag="KNP36_000680"
     CDS             56459..57232
                     /gene="flgG"
                     /locus_tag="KNP36_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgG"
                     /protein_id="HBF0872571.1"
                     /translation="MIRGLYTAVSAMITNQQKQNVVVNNLANMDTNGYKSKQLLTKSF
                     DELKLEGYNNYANGTKQKQIIGDISPGISMDETITNFNQGPIKTTDNKMDVAIQGKGF
                     FLVSDAAGNQFYTRNGNFRTDNQGDLITSEGYYVLGTNTATGAVGHINVGNQKFEVAK
                     DNTISLDGNAMYKFNIVDFNNYNNLKKEGDNLYSGGGAMKVNNALTIQSAIESSNVDM
                     VSEINNMMTISREYEANQKIIQAMDSKLAKIASEIGSVR"
     gene            57253..58014
                     /gene="flgG"
                     /locus_tag="KNP36_000681"
     CDS             57253..58014
                     /gene="flgG"
                     /locus_tag="KNP36_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar basal body rod protein FlgG"
                     /protein_id="HBF0872572.1"
                     /translation="MYTMFYTSKTALSANQSKLDIISNNIANSDSTGYKKINMEYSDL
                     VDEVLNRPSYPTNGKDISTGTGAKATAPMRNYEQGALAPTDSKSNLAIDGEGFFRVIR
                     KDGTYAYTRNGGFNVDALGKIVDDNGNILDVQFDAGYNYNNTNIDSTNLTVSRNGELF
                     VDNKKIGKINLYQPIGTQNFISEGDSLFVATDAAQIKQVEKVDIVQGYRERSNVSLQE
                     EFVDLIATQRAFQMNSKGIKTADEMWQIANNLRAK"
     gene            58037..58918
                     /locus_tag="KNP36_000682"
     CDS             58037..58918
                     /locus_tag="KNP36_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBF0872573.1"
                     /translation="MNDMKEYDFGKPQSYSRENLTCLNFLLAEFCKKYKNYIIYELKC
                     NSSMVVDSIDQVNYQTFLDRVTSSCVVVQNAMEPVMKNFSFRIDRSVADMWIDITSGG
                     TGVVKDNDRELTELDKKVLLHLMDDLVRNMHLFEGFENIQVLDTHTHINLPQLCSPTA
                     PVCVVDLKVLNDNECIGSVSLCFPYNGLEALLESISVIEFFDNDVGDDSEEFTQKIYN
                     SVSNIELSVIAEIGKVSINVEDLLKLEVGDVIVTNKKINDYIDIFVENSKSYTATPGF
                     ISSKKGVKINDAVGKEV"
     gene            58921..59295
                     /locus_tag="KNP36_000683"
     CDS             58921..59295
                     /locus_tag="KNP36_000683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FliM/FliN family flagellar motor switch protein"
                     /protein_id="HBF0872574.1"
                     /translation="MDNSNLISDEEAKMLLNDKVESEVDGDDELALDVSEVNRNNIQR
                     ILDLKLELSVVIGRTKMTLRDILNLHKGSLIELDTLADQDVEILIDNKVLAYGKVVVV
                     DLNFGVKITSIVSEEDMVKSLV"
     gene            59327..60730
                     /locus_tag="KNP36_000684"
     CDS             59327..60730
                     /locus_tag="KNP36_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HBF0872575.1"
                     /translation="MVLILNLNDIKKDILKLNKKDSCSLYNESINNINNNCISTGLKF
                     LKQARDLNPDDVDILNLTGLVNLLKCNFDDAVESFYKSSLCEKTALCEKYINMLTSEE
                     FLIFFEKYNQLIRLINKGMYKEAIQGFKLITDQYCDLIEPYELLALLYDKEEEYIKFD
                     ECLEVLKIIDKENYLLNQENNTLDMYNSANIQTKSNIKVDDYKNEFLHKSSSNHKIND
                     YNDVTKEKSSSKNQKSSDSNKKKSIKKNKYLYIAIILGILLVGQSIYNSYKMNNLTDK
                     ISKNNETKNEESIDSNLTKKENNIEENEDMSKASNINKSNKNINKEDDVKSKKNTVEN
                     EDDKDSDLFTEDELMSKANTLKSEKKTKSSIQLYKKVADIGENKGNTSEATYQVAILS
                     EKLKDYKTAEEYYKMYVENYSEKDAYFDESYYNLGMMYYNNGDLKNSKLTLKKLVNKV
                     PNSMYNNSKVKEILKEE"
     gene            60846..62783
                     /gene="htpG"
                     /locus_tag="KNP36_000685"
     CDS             60846..62783
                     /gene="htpG"
                     /locus_tag="KNP36_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone HtpG"
                     /protein_id="HBF0872576.1"
                     /translation="MEFEKGSISIHTENIFPIIKKWLYSDKDIFIRELISNGCDAVSK
                     HKRLVSLGEISENKSSDYKITVSVNKGEGTLKFIDNGIGMTEEEIKKYINQVAFSGAE
                     DFFNKYKDKMEESNDIIGHFGLGFYSAFMVSKKVQIDTLSYTEGATPVRWISEGGTEY
                     EISESDARNDRGTTITLFIDDDSKEFLDEFTVRGIINKYCSFLPVEIYLEDVERLERE
                     AKEAEEKAKKQKEDGKEEIVDAKVIEPLNDTNPLWLKSPKDCTDEEYKEFYRKVFNVF
                     DEPLFWIHLNVDYPFNLKGILYFPKLKNEFELTEGKVKLYNNQVFVADNIKEVIPEFL
                     LLLKGVIDCPDLPLNVSRSFLQNDRDVSKISKHIIKKVADKLKSLCKNEREEYNKFWD
                     DIQIFIKYGCLKDESFYEKVKECILFKTIDDEYITLQDYLEKCKDKHENKVFYVSDKE
                     QQSQYIKLFKEYDLSAVVLNSSIDTHFISFMEYKENGVKFNRIDADLSDVLKDKNENK
                     DSEENKEEIAKIEGLFKEAVGERVKNYSVEGLKNEDTPAMVLVSEQSIRMAEMQSRFA
                     GMDLGMNFEEEKTLVINENSPIIKKLVSLKDDEEKKDKITLICNQIADLALLSNKELK
                     PDELDSFVQRSNKLMSLLIEL"
     gene            63171..64301
                     /locus_tag="KNP36_000686"
     CDS             63171..64301
                     /locus_tag="KNP36_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBF0872577.1"
                     /translation="MNFNYNLPVNILFGSGRINDVGKEVSKYGKKVLIVTGKNSTKKT
                     GLLDKTIDLLKDSKIEYEVFDRVEQNPLITTIYSGVEIIKSTGCDCVLGLGGGSIMDA
                     AKSIAFSYKNPGDLNDYIFGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKK
                     SIKKNSMYAKASIIDPELMVTMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYG
                     IELISENLIKVYNDVNDLEAWEKITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMH
                     GKGLAALTPTIIESSWDSDIERFGNISKVLGGTCAEDCSDAIRNFLKKIDLDIKLSDL
                     GIEKSDIDWLTDNCMKISVANIKRHPKYFNKEQIKEMYHKSL"
BASE COUNT        26492 a         6607 c        11780 g        19470 t
ORIGIN      
        1 ggtagtagtg gcgaagacac cgtccgaagt agcttggctt tgtaaccacc tctgttgtac
       61 tgtttaagta taaataagtg tgttagccac caagaatccc cttgctttag ctatggggag
      121 tgtgtcaata aaatacttta atgaaaaata gctaacttta attgtaggat attcttaata
      181 tatttgaaat aaataaaaat attgaaggat ataatattca actggtatat aaataataaa
      241 tgatagttaa attttacctt agaggctaat taggtgttta gtcaaagcta atgcctttag
      301 aatacaaatg tattctaaag gcatttttac tatgtatttt catttatatt actaaacatt
      361 atctattttt atatacattt ctatgtattt tattttcatc aaatcggtct ataaactcat
      421 ttttttcttc actatatcca atagatataa gtgcataagg aactaatttt aatggtaagt
      481 ctaaagtttg tctaacttta tttaccactt tatttttagg aaatactcct gcccaacaag
      541 cagctagacc ttgattagta acttctaata ataaattttg tgtgcaagca cctaaatctt
      601 gtatccattt accaggtttt aagaatttat ctctatttcc aagcactact atacataatg
      661 gtgcaaattc tatatgcttt gctctatgct gtgactttga gagctgtttc agcagttcct
      721 tatcatctac tataataaat tcccaaggtt gagcattttt tgatgaaggt gcttgcatag
      781 ctgattttag tatttcagtt attttatctt cttctatatt tttatctata tatgttctta
      841 ttgaacgtct attttttata acttctaaca tacagattct cctttaaata aaattatttc
      901 tatttatata atatcattac tttaaatttt agctattact tatataaaga ataaactttg
      961 tgttggtttt atctaagtaa aagtaacatt cagaactaaa aaacaagact ataaatccaa
     1021 agtattaatt aaaaaagaag taataaaaaa taatatacaa gatttaaaaa agagtattgg
     1081 gcttaaaatt taattagaaa accaattttg agataatctg ttttttattt taacaaaaaa
     1141 acataaataa agttcgatac gtagcgaatg aaaaaattac aagaaatatt ttttttaaaa
     1201 aatttcaaaa aagagttgat aatatatgta tattaatata aaatttaagg tgtataattc
     1261 gtataataat acgaatgatt tgtagtgtaa aataacttat aaacggagag gggaagtcta
     1321 atgaaagtag cagtagttat gggttcaaaa tcagattatc caaaattaga agaagggata
     1381 aaactgcttg aaaaatatgg aatagaagtt gtagcaagag cattatcagc tcatagaaca
     1441 ccagaacaac tttcaatatt cctaaaagaa atagaagatg atactgatgt aataatagca
     1501 gcagcaggaa aagcagcaca cttaccaggt gtaatagctt cacaaacatt aattcctgta
     1561 ataggattac ctattaaatc atcaactatg gatggactag actcactttt atcaatagtt
     1621 caaatgccaa aaggaatccc agttgcaaca gttacaatag acttaggttt aaacgcagct
     1681 ttattggcat tacaaataat gactttaaaa tacccaaaat taaaagagga tttgaaatca
     1741 tatagagaag agatggcaca aaaggtgtta gaagacgaca ataatttaag ggggtagcag
     1801 aaatgttatt atatgaagga aaagcaaaac aagtatattc tacagataat gaaaatgaat
     1861 atgttgttta ttataaagat gatgcaacag catttaatgg agaaaaaaaa gcagaaatat
     1921 cttcaaaagg tatactaaat aataagatat caacaataat ctttgaaatg ttaaaagaaa
     1981 ataatataaa tactcacttt ataaaaagtt tatcagatag agaaatgtta gttaaaaaag
     2041 tagagatttt accattagaa gtaatagtaa gaaatattgc tgctggttct atctgtaaaa
     2101 gagttggtct tgaagaaggt gtagttttcg atgagccaat ttttgaaata agctacaaaa
     2161 atgatgctta tggtgaccca atgctaaatg atgattatgc agtggcaatg aagttagcaa
     2221 ctagagaaga gttaaaattc ttaagagaag aaactttaaa aataaatgag ttactaaaag
     2281 catttttctt aaaattaaac ctaaagttag ttgactttaa aatagaattt ggtaaggatt
     2341 ctgaaggaaa tataatattg gcagatgaag tatcaccaga cacttgtaga ctttgggatg
     2401 taaatacaaa tgaaaagtta gataaggaca gatttagaaa agaccttgga gaccttgtag
     2461 aaggttatac ggaagtactt tcaagaatga ataataaata ggaggcaaat gtatgtgtgg
     2521 agttttaggg atttactcta ataaagatgt aactaaagaa ctatattatt ctttatattc
     2581 tatgcaacac agggggcaag aaagctgtgg tttagctctt ttagatgatg gagaaattaa
     2641 gtacaaaaaa gatatgggat tagttggaga tgtttttaag gaaaatgaat tatctaagtt
     2701 aaaaggaaat atagggattg gacatgttag atattcaaca gctggaggaa gtcatgtttc
     2761 taattgtcaa cctttagttg gaagttgtag aaaaagacaa ttagccatag ctcataatgg
     2821 aaatctagtt aatgcaaatt atttaaaaga tatgctagaa gaagatggat atatgttcca
     2881 aactaattca gatacagaag tgattttata tatacttgct agatattaca aaggggatat
     2941 agtagaaagt ttaaaagtga caatggatta tataaaaggt gcatatgctc ttgtaataat
     3001 gagtcaagaa gaattggttg cagttagaga cccacatgga ttcagacctc ttgtacttgg
     3061 taaaaagggt gatgaatata tatttgcatc agaaaattgt gcaatagata tacttggcgg
     3121 agaagttata agagatgtag agccaggaga gataatagta gtcaaaggtg gagaactaaa
     3181 atcatatttt tattcagaaa attataaacc agttaagaaa agttgtatat ttgaacacat
     3241 atactttgca agaaatgatg caactataga caatgtaaat gcatatgaat ttagaattaa
     3301 atgtggtgag agattagctc agaatgaaac tgtaaaggca gatatggtag ttccagttcc
     3361 agattcaggt tggccaggag ctattggtta tgcaaatgct agtggattaa aaataagtga
     3421 aggcttagtt aaaaatagat atgtaggaag aacatttata aaacctacac aagaagaaag
     3481 agaaatagca gtaaaaataa aattaaatcc tctttcaaca ataataaaag gaaaatctat
     3541 aattttagta gacgactcaa ttgtaagagg aactacatct aaacaattag taaaatcttt
     3601 aagagaagca ggtgcaaaag aaattcatct tagaataact tctcctccag tagcttactc
     3661 ttgttactat ggaatagata ctccaaatcg ctctaaatta attgcatcaa gtaacaacgt
     3721 agaagaaatg agagaatata ttggatgtga tagtttaaaa ttcctagata tagaaggaat
     3781 gttagatgca acagaacata agtctacttt ctgtaaagct tgttttgatg gagaataccc
     3841 agttaagaaa attgataagg aggaactact ttcatgttaa catataaaga atcaggtgta
     3901 gatatagatg aaggaaatag agcagtagac cttataaaag gtaaaataaa aggaacttat
     3961 gatggaaatg tagttggaga tttaggtaac ttcagtggat tatacagttt aaaagatttt
     4021 gtaggtatga aagaaccagt tttgcttgca tctacagatg gtgttgggac taagttaaaa
     4081 atagctcaga tgatggacaa gcatgatact gttggaatag atttagttgc aatgtgcgtg
     4141 aatgatttaa tttgtcaagg agcaaaacca ttattcttcc ttgactatat agctcttggg
     4201 aaattagtgc ctgagcatat agaaaaaata gttggtggaa ttgcagatgg ttgcaaaatg
     4261 tctggttgtg cactaattgg tggagaaact gctgaaatgc ctggaatgta tggagaagat
     4321 gactatgatt tagcaggatt ttctgtggga atagcagaca aagaaaagat tgtttctgga
     4381 aacaatgtta aatcaggaga tgtattggtt ggtatatctt caagtggagt acacagcaat
     4441 ggattttctt ttataagaaa gatattttta gaaacttaca attataaaat ggaacgatat
     4501 gttgaagaac taggaatgac agttggagaa gcacttttaa caccaactaa aatatatgtt
     4561 aaattagctt tagatgtatt agctaaacat gacataaaag ctgtagctca cataactggt
     4621 ggagggctta tagaaaatat aacaagagtt atacctaaag gattaggact agatatcaat
     4681 aaaaaatctt gggagaagcc tcctatattt aaaatgatag aaggttttaa tgctgttgat
     4741 gagagagaac ttcataagag ttttaacatg ggtattgggc tagttttaat agtagataaa
     4801 gaaaatgctg atgatgttgt aaactttata aataatagag aaaatgacaa tgctgattat
     4861 gtagataaaa aatatagtga attattagaa gataaagctt atataattgg tgaagtagta
     4921 gatagtcatg aaggtgtaga attatgctaa atataggagt tttaatatct ggtgggggaa
     4981 caaatttaca agcagttata gatggtactg agtctggaga aataaaaggt caggttaaag
     5041 tagttatctc aagtaagcaa ggtgcttatg ggctagagag agctaaaaat cataacataa
     5101 aagcaatttg tgaaactgat gaagacaaga taatagaaat tcttaaggaa aataaaatag
     5161 atttagtagt tttggctggt tatttaaaaa taatcagccc aaagctggtt aatgagttta
     5221 gaaacaaaat gataaacata catccatcat taattccttc attttgtgga gctggattct
     5281 atggagaaaa agttcatcaa ggtgttatag attacggagc taaagtaact ggtgctacag
     5341 ttcattttgt tgatgaaggt gctgatactg gaccaatcat aatgcaagat gtagttaagg
     5401 taaatcaaga tgatgatgca aagacacttg caaaaagagt gttagaagtt gaacatagga
     5461 ttttaaaaga aagtataagt cttttttgtg aaaataaatt aaaacttcaa ggtaggagag
     5521 tgtttataaa tgagtaagag agctttaata agtgtaactg acaagactgg tgtagtggaa
     5581 tttgctaaag agttaaataa attagattat gaaattatat ctacaggaaa tacatttaaa
     5641 acattaaaag aaaatggtgt taatgtaatg caagttgaag atgttacaaa ttttccagaa
     5701 atattagatg gaagagtaaa aacattaaat ccatatatac atggtggtat actttataaa
     5761 agagataaag aatctcatgt agaaactgta aatgaacata aaatacattc aatagattta
     5821 gtagctgtaa atctatatga ttttgaagga actttaaaag ctggaaaaag tcatgatgaa
     5881 ataattgaaa atatagatat tggtggacca tctatgatac gttctgctgc caaaaactat
     5941 aaggatgtaa tagtagtagt agatataaaa gattatgatt ctataataga aaaattaaaa
     6001 acagatacaa tgacattaga agacagaaaa aaattatcat ataaagcttt ctcaactaca
     6061 ggaagatatg atgcgttaat atctagttat tttgctggag aagttggaga tacgtatcct
     6121 gacatattaa atttaacttt ccaaaaagaa caaactttaa gatatggaga aaatccacat
     6181 caaaatggtt tcttatattc acagtcaaat gcaaaaaatc caatcttaaa ttatgagcaa
     6241 ttaggcggta aagaactttc ttttaacaac ttaaatgatt tacatggatg tttagaagta
     6301 atgagagaat ttaaagatag tgaagaagta gtttcagtag ctataaaaca tgctaattca
     6361 tgtggggtag gtttaggaaa agatgctttt gaagcatata caaaatgtta tgaagcggat
     6421 aaggtttcaa tatttggagg aatagtagga ataacttcta ctatagataa agctacagca
     6481 gagaaattaa atgaaatatt cttagaaata gtagtagcat atgattttga accagaagct
     6541 ttagagatac ttaaacaaaa gaaaaatcta agaatattaa aattagctaa aatagaaaat
     6601 agtttacaac catatgaaat gaaatattta gatggaaaat tattgataca agatagaaac
     6661 aatatattag cagaaaaaag tgaaaatgta acaaaggaaa aaccaacaga tgcacaactt
     6721 aaggacatgg aatttggtat gagagtagta aaaaatatga aatcaaatgc aattgcaata
     6781 gtaaaaaatg gacaaactct agctttaggt tgtggacaaa catcaagaat ttgggcatta
     6841 aaaaatgctc ttgaaaataa caaagataaa gattttacag gagctgtttt agcgtcagac
     6901 gcatttttcc catttgatga ttgtgtaaca ttagctcatg aatatggaat atcagcagta
     6961 gttcaaccag gtggctctat aaaagataaa gattcaatag aagcttgtga caagtatgat
     7021 atggttatgg tatttacagg aataagacac ttcaaacact aaggaggata ttatgaagat
     7081 attggttgta ggcggtggcg gaagagagca tgctatatgc tggaaactaa gcaaagaaaa
     7141 aaatgtagaa aaaatttatt gtgcaccagg taatgcagga attgcaaacg tagcagaatg
     7201 tgtaaatata ggtgatacta atatagaaga acttttaaaa tttgccaaag aaaatgaaat
     7261 aggtctgaca atagtaggac cagaagtacc actagttatg ggaatagtag atgagtttga
     7321 aaaagaagga ttaagagtat ttggacctaa taaaaaatgt gctcaacttg aaggaagtaa
     7381 agctttttca aaagaattta tgataaaaca taacatacct actgcaaaat ataaagaata
     7441 tacaaactta gaagaagcta tatcagaaat agatagtttt ggatatccag tagtaataaa
     7501 agcggacgga ttagctgctg gaaaaggtgt tgtaatacct gaaaatagag aagatgctat
     7561 agcaacttta aaagaaatga tgtcagataa gaagtttgga gctgctggag ataaaatagt
     7621 aattgaagag tttttaaaag gaatagaaac ttcaattcta gcatttgtag ataatgatac
     7681 aatagttcct atggcaagtg caaaagacca taaaaaagta aacaactatg agcaaggtcc
     7741 aaacactggg ggaatgggaa ctttttcacc tagtgaaata tatacagaag aattagcaaa
     7801 taaagtaaaa gagacagtat tagaaaaaac tttagaaggc ttcaaaaaag atggacttaa
     7861 ttttaaaggt attttatttg ttggtcttat gataactgaa gatggagaaa aagtacttga
     7921 atataatgta agatttggag accctgagac acaatctgtt ttatttagat tagaaacaga
     7981 tttacatgag ataatggaag ctatactaga taataagtta aaagatatag aaataaacta
     8041 tagtgatgat gaagctgtat gtgttatgct tacatcagga gggtatccag acagttatga
     8101 aaaagggaaa attataactg gtcttgaaaa cttggatgat gatatagtag tattccatag
     8161 tggcactaag atgtttgatg gtaatttggt taccaatgga ggaagagtaa ttggtataac
     8221 tgcaaagtca actacagtta aggatgcagc agaaaaagtt tatgaaaaca taaagaagat
     8281 aaactttgaa ggaatgcact atagaacaga cataggaaga taatttttct aaaatggagg
     8341 ataaggtatg ttgaatactg aaaataaaga ctcaatggtt agaagagtat tagttgaaaa
     8401 aagagaaggt tttgaccttg aggctaaagc tttaaaaaaa gacttagtag aaagtttaca
     8461 catagataat atagaaaatt taagaatatt aaatagatat gatgtagaag gaatatcaga
     8521 agaagtttat gaaaatgcag caaagacaat attctctgaa ccaaatttag atgtagtata
     8581 ttatgaagaa ataccaaaat taaatgatga aagagtattt gcaatagaat ttcttcctgg
     8641 tcaatacgac caaagaggtg attgggcagc tcaatgtgta caaattgtaa atcaagggat
     8701 aagacctgct attaatacag caaaagttta tatattatca ggcaaaataa ctgatgaaga
     8761 gttttctaaa ataaaagatt actgtataaa tccagtagat agtagagaag catctttaga
     8821 aaaaccagaa acgttaaaaa tggaaactga aataccaaca acagttgaag tattagatgg
     8881 atttatagat ttagatgaaa atggattaaa aacatttgta agtgaaaaag gattagcaat
     8941 gactttagga gacttacaac acgttcaaaa atactttaaa gatacagaaa agagaaatcc
     9001 aactataaca gaaataaaag tattagatac ttattggtct gatcattgta gacatactac
     9061 ttttatgact gaaatagaaa atgtaaagat agaagatggt aagtttaatg atatagtaaa
     9121 agaagcgtat caaatgtatc ttaactcaag agacaatgta tatgtgaaca gacataaaga
     9181 tatatgttta atggatatag ccactgttgc agtaaaagaa ttaaagaaaa atgggaaatt
     9241 aaatgaccta gatgaaagtg aagaaataaa tgcatgtagt ataaacgtag atgttgaagt
     9301 tgatggtaag atggaaaaat atctagtaat gtttaaaaat gaaactcaca accatccaac
     9361 tgaaatagaa ccatttggtg gagcagctac ttgtttagga ggagctataa gagacccatt
     9421 atcaggaaga agttatgttt atcaagcaat gcgtgttaca ggaagtgctg acccaagaac
     9481 gactttagaa gatactttac ctggaaaact tatgcaaaga aaaataacta cagaagctgc
     9541 tcatggatat agttcatatg gtaaccaaat aggtcttaca actggacaag ttgcagaagt
     9601 atatgatgaa aactttgttg caaagagaat ggaaataggt gcagttatag cagcagcacc
     9661 aaaagagaat gtagtaagag aaagacctga agcaggagat gtaatcgttc ttcttggagg
     9721 aaaaacagga agagatggct gtggaggagc aactggttca tctaaagaac atagtgaaga
     9781 gtcaatctta acttgtagtg cagaagttca aaaaggagat gctcctaacg aaagaaaaat
     9841 acaaagattc tttagaaata aagaagttgc tcaaatgata aaaagatgta atgattttgg
     9901 agcaggtgga gtttgtgttg ctataggaga gattgctgat agcttagata taaacttaga
     9961 cttagttcct aaaaaatatg atggacttga tggaactgag cttgcaattt cagagtcaca
    10021 agagcgtatg gcagtagcca taaaaaaaga aaataaagat aaatttatac aattagcagt
    10081 agaagaaaac ttagaagcta cgcatgtagc tacagtaaca gatacaggat atttaagaat
    10141 gttctggaat ggaaaagcaa ttgtagatat aaatagagag tttttagata caaacggagt
    10201 aaaacaaact actgatgttc atgttactaa agtagatgaa gaaaatacat tctttagctc
    10261 taatgaaata gtaaaagatg ttaagtgtgc aagtatgaaa gacaagttta caaaagtact
    10321 atctgacctt aatgtttgtt ctcaaaaagg attagtagag atgtttgata atacaattgg
    10381 tggtaataca gtacttatgc catttggagg aaagtatcaa gcgactccaa cacaaggtat
    10441 ggttgctaag ataccagtac ttggaggaga aactaatact tctacaataa tgacttatgg
    10501 atacaatcca aaggtaggaa aatggagccc attccatggt gccttgtatg cagtagtaga
    10561 atctgtgtgt aaattggttg ctattggagg aaattatagt acaacaagac ttacattcca
    10621 agagtatttt gaaaaacttg gtaacaatcc agaaaaatgg ggtaaaccat tctcagcact
    10681 tttaggagca ttttatgcac aaagtaaatt tgagatacct gctataggtg gaaaagacag
    10741 tatgtctggt acatttaaag atattgaagt tccaccaaca ttagtttcat ttgctgttga
    10801 cacagtagat gcgaagaaag tagtatctcc agaatttaaa aaagcagact caaaagtagt
    10861 aatgttatgt gtaaacaagg cagaaaatga tgttgtagat tttgaggaat taaagagaaa
    10921 cttagataaa gtaagagaac ttatacatgg aaataaagtt ttatcaacat atgcattagg
    10981 atttgcaggt gtaggtgaag caataagtaa aatggctttt ggtaataaaa taggatttaa
    11041 gtttagtgaa gaggctgaaa aagcatttac agatgataaa ttatttgagg ctagttatgg
    11101 aaatatagta cttgaattag caaatgatga tttaagtatg ttagaaggat acaattatgt
    11161 tgtgcttgga agtacagtta aagaaactag tatatttatc aaaggtgaag aacttgcatt
    11221 agatgaatta tataaagcac attgtagtac tttagagcct atattcccaa ctaaaacaga
    11281 agaagtaaaa tcaaagatag aaactataag ttatatatca caaggagaag ctaaaaaatc
    11341 atcattaagt atagctactc caagagtatt tataccagca ttccctggaa caaactgtga
    11401 atatgactct gcaagagcat ttgaaagagc aggagctaat gcaagtataa gagtatttaa
    11461 gaatttaact tataaagaca tagaagattc tatagataca atagtaaacg aaataaaatc
    11521 ttctcaaata ataatgttac caggtggatt tagtgctggt gatgagccag atggttctgg
    11581 taaatttata gctactgtat ttagaaatcc tagagtgcaa gaagctataa atgaattttt
    11641 aactcaaaaa gatggactaa tgttaggtat ctgtaatgga ttccaagtat taattaaatt
    11701 agggttagtt ccatatggag aaataagagt tccaagtgaa agtgctccaa cacttactta
    11761 caataatatt ggtcgccatc aagctaagat tgctagaact agaatttcat ctaataaatc
    11821 tccttggtta gctcaaacta atgttggaga tattcataat atagcaattt ctcatggaga
    11881 aggtaagttt gttgccagtg aagatgttat gagagaatta attgctaatg gacaagtagc
    11941 aactcaatat gttgacttta ataatgaagc tacttatgat attgagttta atccaaatgg
    12001 ttcattctat gctgttgaag gtataactag tgctgatggt agagtgtttg gtaaaatggg
    12061 acattctgaa agaattggtg aggaagtata taagaatatt ataggtgaaa aagaccaaaa
    12121 gatatttgaa tctggagtta aatattttag ataaagcttt gatgtttaat tgatagctag
    12181 aatatataat ttagatattt agatttaaag agatgtaata atatgatgat aatcatttaa
    12241 tattacatct cttttttatt tatctaagaa ataataagtt caacctaagt taaaatacaa
    12301 gctgtgttat aattaattat taagtaaaat tgaatattta ttggaggaca acataattaa
    12361 tgaaaatatt aataacaggg tctaatggtc aattaggaaa agaattggtt aaccaattag
    12421 aagcaatcaa tcaaagtata aaccaaccaa aatatgttat attagctaca acaagaagtg
    12481 atttggacat atccaatcag actaatgtag ataattttat tttgcataat aaacctgatg
    12541 tagttgtaaa ctgtgcagca tatacaaagg ttgatgcatg tgaagataat atcgaaattg
    12601 catacaaaat aaatgcttta ggagtgagaa atctagcaat agcatcagaa aaagttaatg
    12661 ctaagcttat tcacatatca actgactatg tattcaatgg tttttctaaa tatccatata
    12721 gggaagacaa taaaactgaa cccaattctg tatatggaaa aagtaaactt atgggagaaa
    12781 aatttgttga acaattctca cataagtact ttatattgag aacagcatgg ttatatggta
    12841 atgggaataa ttttgtaaag accatgataa aactttcttt agaaaataaa gaggttaatg
    12901 tggttaatga ccagtttgga actccaacaa gtacagtaga cttagcaaaa attataataa
    12961 aaatcatgga aacagaacat tatggagttt atcatgctac atgtgaaggt gagtgtagtt
    13021 ggtatgattt tgccaaaaag atatttaaac taaaaaatat agatataaaa gtaaatccaa
    13081 ttaagagtaa cgaatttaaa tgtaaggctc caagaccact atattctgta ttggataatt
    13141 ttatgttgaa gttaattggt ttaaattctt ttagaaagtg ggaagaatcc attgaagaat
    13201 atttagaaag atatgatata aatgaaaagt aaatgtatta ttttgagaaa agaaaataag
    13261 atattataaa aaatataaat atttctttta tttatccgat aatcataata tgacaaaaac
    13321 aaatttaagg atggaaaaag atgaaaggaa ttattttagc aggagggtct ggtacaagac
    13381 tatatcctat aacaaaatgt atatcaaaac aaacacttcc aatatacgat aaaccaatga
    13441 tatattaccc tatgtcggtt cttatgttgg cagggataca agatatatta ataatatcta
    13501 caccaagaga tataaaagca tttgaagaat tatttggaga tggaagttca ctagggctta
    13561 acataacata tgcaattcag gagaaagcaa atggaattgc agaagcgttt ataataggag
    13621 aagaatttat aggaaatgac agagtgtctc ttgtattagg ggataatata ttttatggat
    13681 atggatttag tgaaaggttg gagaatgcag ttaaaagaaa aggagcaact atatttgggt
    13741 atcatgtaag taatccaaat tcgtttggag ttgtagaatt tgataaggat tttaatgtat
    13801 tgtcaataga agaaaaacct acagttccta aatctaatta tgctatacca ggattatatt
    13861 tttatgataa tgatgttgta gagatagcaa agctagttga accgtcagat agaggtgaat
    13921 tagaaataac ctctataaac agtgaatatc taaaacgagg aaaactaaaa gtggaacttc
    13981 taggaagagg tatggcttgg cttgatactg gtacacataa aggtctattg gatgcttcta
    14041 attatgttga agtggttcaa acaagacagg gactgtatat agcatgttta gaagagattg
    14101 catatacaaa aggatatata agtagagaac aattaatgaa actagccaag ccactgataa
    14161 aaactgaata tggtcaatat ctattaaaat tggctagtga agatatgtaa tatggtagat
    14221 aaaatttatt ataaatttta ttaagggagt ttattataat gggaaaaatc aatgttataa
    14281 agactaaaat agaaggatta tatatagtcg aaccaaatgt attttatgat gaaagaggat
    14341 attttatgga aagctataat aaaaaggatt ttatagagca gggtcttgat atgtgtttta
    14401 ttcaagataa tgagtctagc tcaagaaaag gcgttttaag aggaatgcat tttcaggtta
    14461 aatatcctca aggaaaatta gtcagagtta cagagggaga agttttcgat gttgcagttg
    14521 atttaaggaa agattcacaa acatttggga aatgggaagg tgtaatattg tctgataaga
    14581 ataaaaaaca attttatatt ccagaagggt ttgcacatgg atttttagtt ttatcagaaa
    14641 aagcagtatt tagttacaaa tgtacaaatt attattaccc agaatttgag aatggcttta
    14701 tatggaatga caagcaaata tctattgagt ggcctttaaa aggaattgaa gaaatatttt
    14761 tatcagaaaa ggacaaaaaa caaaaaagtt ttaaagatat ttgtacaaga cgttaataaa
    14821 aatttattag aattaacatt taggagaaaa aatatgaaaa aaatactgat aactggagga
    14881 gcaggattta ttgggagtaa ttttatacat tatatgctta acaagtatgt agattatttt
    14941 attgttaacc tagacttgtt gacttatgct ggtaatttag agacattaat agaaatacaa
    15001 gacaattcca attataaatt tgttaaagga gatatttcaa atagggagca ggtgtataag
    15061 ctatttgaag aagaaaggtt tgatatagtt gttaactttg ctgctgaatc tcatgtagat
    15121 aggtcagttg agaatcctga tttatttatt aaaacaaaca ttataggaac acaagtactt
    15181 ttagatgcat ctataaaata tggagttaaa aggtatcatc aaatatctac agacgaagtg
    15241 tatggtgatt taccaattga tagaaaggat ttattcttta cagaacaatc ttctatcaat
    15301 ccaagttctc catattcagc ttctaaagca tcagcagatt tattggtaag ttcttattat
    15361 agaacatatg gattgttaac aactatatct aggtgttcca acaattatgg gccatatcat
    15421 tttcctgaaa aattgattcc tcttatgatt ttaaatgctt tggaaaacaa acaattgcca
    15481 gtatatggga atggggaaaa tgtaagagat tggttacatg tatatgacca ttgtactgct
    15541 atagacttaa taatacataa aggaaatata ggggagattt acaatatagg aggtcataat
    15601 gaaagaagta atctagaagt agtaaaaatg atattaaatc ttttaggtaa atctgaagag
    15661 ttaatatcct atgtaaatga tagacctggt catgatttaa gatatgctat tgatgcaact
    15721 aaaatagaga atgagttagg ttggaaggca aaatatgact ttgatttggg tataaaagaa
    15781 actgttaagt ggtatataga aaatgaatct tggtggaaag ctgttttatc agtataactt
    15841 taaaatttag aaaggggcgt tttatattga atgagataag ttcactaatt aatatattag
    15901 cattgactca attatctggt agtaatacta caaatcaatg taattgtaca tataataatt
    15961 catctggatt tgatatgatt atgatgacct tgttaaaagc attatcacaa aataatcaac
    16021 atacttctaa tagctacaat ttattgtcta attctgagaa tttatttaat gaacttgata
    16081 atgtagtaaa taataccact agtagattta tagatgttga tacaaaagat aaaaatgtaa
    16141 agttgagaat tgaaaatgct gtaaatcaag catcaaaaaa atataacgta gattcaaatc
    16201 ttataaaagc aataattaaa gttgaatcag attttaatcc aaataccgtt tcttctgctg
    16261 gtgctaaggg tcttatgcaa cttatgccag aaaactgcag agacttaggg gttacagacc
    16321 cttttaatat agaacagaat atagatgctg gaactagaca tattaaggaa tacattgata
    16381 tgtttggagg gagcatagaa atgggattga tggcatataa tggtggtcct ggaagaatga
    16441 aaagtagagg agtagaatca atctctgacc tgtataaaat gccaaaagaa acacaaaatt
    16501 atattcctaa ggttatgaaa tattatagag ggtaggcttt attatgggaa taaatataga
    16561 taagctaaac ataagtccaa gtataaatat ggaggttaaa aaactaaaag agagtaataa
    16621 attttctgac aaattaaact ctttaaaaca atcttcttca ttggaagata taaaacgaaa
    16681 tttggaaagt gtaaaaaagg caggagaaag gcttgtactt actcaaaact atggcgatat
    16741 tagtatatat aaaaatgcag taaaagaata cctaaaatct gttgtagata atatgtattc
    16801 acttgataaa aatagtagct tttgggagca tcagtattat aagaatgtaa agattgttga
    16861 tagtaaactt gaggatatga ctagtaagtt aattagtgaa gaaaaagaaa acatagatat
    16921 tgtttctact gttgacatga tacaaggctt attgatagat atgtatagat aaggttatac
    16981 aaggagaaaa attttatgaa tagcaaaaaa gaggatatat atgaattgaa ttttgggcaa
    17041 ttaatagaag aaaaatctgg tgttatagaa gaaaatcaaa atgtttttaa tgcaaaagta
    17101 aaggtagctg tttctatagg aaatacaaca gaaacaataa aaaatatatt agatttaaaa
    17161 gaaggctcta taataaaatt aagtaagaat gtggatgaaa aattagatat atatgcaaac
    17221 gatagattgt ttgcttatgg agaaagcatt attacaaatg agaagttatc tgtaagatta
    17281 tctaaaatag aagattcaga tgtaaattag cattttaaat atatcccttt agtctattct
    17341 gtatgagttt agctaagggg atatttttat aaaaaattta aaatatgtgt gaattatata
    17401 aatattttta ttttatgagc gataactaaa ttataagtat gtaattttgg aggtgaaact
    17461 atggatatta aaaatgtaag ttcaaatatt gtagtgaata attatttaaa gaatacatct
    17521 ggtataaaaa aagtggaaga ggttaaaaaa attaataaaa cagacaagat agagttatct
    17581 aaatttgcaa aggaaatggc aagtgtgtca aatatgagtg atgagaatat tagaaataaa
    17641 aaagtcgatg aaataaaaaa tgcattagaa aatggaactt acaaaataaa accaaaagaa
    17701 attgcgaaaa aaatgataga ggatatgcga ggataaagtc atgattacag acttaaaagt
    17761 tataatatat gaagaaaaaa atataattag taagatgatg gaattattaa aagaacaatt
    17821 tgattatata gttgaaaaag acttagaaaa tttaaatatg ttaaatccta aactagaaga
    17881 tattagcagg gagcttgcat ccatagaaat aaagagaaga caactttttg gtaatgatat
    17941 ttcaatgagt gaagttgttg aaaatagtaa tgatggatat ttaaaagaaa tatatacaga
    18001 cttgaaacgc attcttgctt tagctaaaaa tcaacaagaa tcaaatgatt ctctaataaa
    18061 gaaagaactt atttttacga aaaaaatgat taatttcata aaaccagctg ataagcaaac
    18121 tacaacttat aattcttatg gaaatattag aaaataaata ttaggaggag aaatatggca
    18181 ggattatttt ccattttaaa tacagctaat tcaggaatga atgcgcacca aaaagcaata
    18241 cagacaattt ctcataatat aagtaatcta gatacagacg gttattctag gcaaaggacc
    18301 gagtttgcta caaatagtcc aatgtatatg cctagtttga gtaattcaat tgcaagagga
    18361 caattaggga ctggagtaca tgtaacggat gtaacaagag ctagaaatag tttttatgat
    18421 taccaattta gggcagaagc tcataagtat ggtaagacag tttcaaaata tgattattac
    18481 aatactatag aaactatact aaacgaacca tcagactatg gaatatctgc aggtatagat
    18541 gattttttta aaggatggga gtcattatca aaggatataa atagtgacag taaaaaaagt
    18601 ctagtggtag aaaacgcatc taatttagca actttaataa gtgaaagtta taagaagctt
    18661 gataagttaa aagaagatat agattctaat atagacactg agataaaaca aataaatgac
    18721 atgttaaaaa gtcttgaaga tttaaataaa tctattgata ttatatctgg ttctggctct
    18781 acaccaaatg atttgcttga tgaaagagat agaattttag ataacttgag ttttaaacta
    18841 gactttgaaa atagtgatgt taaaaatatg cttgcagatg gtaaattaga acttaatgaa
    18901 ttaaaaaatc cagatggaac ttggaaaaca ggtatatcag ggaccttaca aggcttgttt
    18961 gaaatgcatg gtaagattga tacatataaa agcgatttaa aagatgtatc tgatggatta
    19021 gctaaacaga taaatgatgt ttataatacg tctgcaggaa taacagtaac agattttttt
    19081 ataacttcaa atgtagatgg tgaagatatt ataaagataa atccagctat aaagagtaac
    19141 ccaaatgaat taaagcttac tgctgatgaa gcttcaaaaa ttgctaagtt aaaggatgaa
    19201 aaaatagata ttggggtggc tggtggaaaa gtaagtacaa taagtgacca ctataaagcc
    19261 tttgcagaat caatcggttt agattctcaa aaagtaaatc aagatgaagc aaatcaacgt
    19321 aaaattataa ataatattga taactcaaga atgagtgttt caggtgtatc tttggatgaa
    19381 gaaatgacag agcttataaa aatacaacgt tcatatcaag ctagtgcaaa agttatgtca
    19441 acagctgtgc aactactgga tgttgtaata aatggaataa tttaatagaa gggggaattt
    19501 ataatgagag tcagtacagg tatgatgtct agcagctatc taaactcact acaagataat
    19561 ctacaaagat tggataaggt taatagacaa gttaatacaa caaaagaaat aaacaagcta
    19621 tcagataatc catataaagc aataaagata ttaaactcaa aaagtgaaat aaagactatg
    19681 gagacttatg ttgagaattg taaagataca gggaattggt tagaaactac tgatactgca
    19741 ttagatcagc ttggaaaatt attatcagac ataaagaaaa ctttggtggc aagtggtgat
    19801 ggtgcatact cagatgatga attaaagact cttagtaatg aaactaatga aaaaatgaaa
    19861 gaaattgcaa atgctttaaa tgcaacacat gaagggaagt acatattttc aggttcaaat
    19921 acgggggtac cacctgttga atgtatagat aatgctgatg gttcagtgag tttaaagttt
    19981 aattctagtc taaatcttaa taaattaaat gactctttga gtatggatat agctcaagga
    20041 ataagtgtag attataacgt taaattgagt agccttggat ttgacccaac aaaaactgac
    20101 ccatttgaag agttaaataa catatcaaaa aaattagcaa atccagatgc tgatgctata
    20161 aaagagctta caacaacttg tttgggcgat atggaacaac taatagaaaa tacagtaaat
    20221 gttaggtcta tatatgggac aaaagcaaat acagtagagg ctatgaagga aaaaaacgat
    20281 gatagtttga tacagttaaa ggatattttg tcacaaaatg aagaaataga ttatggtgaa
    20341 aaacttgttc aattaaaggc agcagagtta acttatcaag cttcactaca aacaggagga
    20401 aagttattta atgtatctat attagattac atataataaa ataacgcaga tatgatgaag
    20461 gttacattaa aaaaaggtat attaggtttt gaaaatttaa aagaatatga gcttttagat
    20521 atagaagata atgattattt aaaagaattt aattctactg aagaagaagg tataggattt
    20581 gttgttgtat ctccatttga gattatcaat gaatatgaaa tagttttaaa tcaggaaaca
    20641 atagaaaaac tagaagtgaa atctccaaag gatgttgtat tatttaatat aattactctt
    20701 ggtcagacat ttgaagaatc aactgtgaac atgaaagctc ctatagtgat aaatataaaa
    20761 actaattttg gaatgcaaat aattttacag gatgataaat attcaataag gcatccatta
    20821 ttgagaggtg ataatggatg ctagtaattt caagaaaaaa agatgaagca gtacttatag
    20881 gagaaagcat agaagtaaaa attgtaggag tagatggaaa caatgtaaaa ctagctatat
    20941 cagcgcctaa caatataagt atattaagaa aagaaatata cgaaaaagta aagagtgaga
    21001 atataaaagc tacaaataaa aatataaaaa ttttaaagtc attaaaataa taagcttgga
    21061 ggaagtaata tatgtatgga gaaaatcctt ataattctta taaacaaaat gctgttttta
    21121 tggcatcaaa ggaacaattg ttacttatgc ttgttgatgg agcagtaaaa tataccaaaa
    21181 tagccagagc agctatctta gataaaaata cacagaaagc gcatagagaa cttgtaagag
    21241 ttcaggatat atttacagaa ctaatggtta cattagacca aaatgcagga caatgggcaa
    21301 aggatatgta caaagtttat gattttgtaa gatatgaact ttcaagagcc aatattagaa
    21361 aagacatcca ggtaatagat aatgtgttac ctgtaataga acaaattaaa gatacatggc
    21421 atgaagctga taaaaaaagt aaagaagaaa gaagtaggta caaataatgg aattaaattt
    21481 agctgaatta gataagttat caaaagagga attactattg atgcttgtag atggcacagt
    21541 aaaatatacc aatatatcca aagaagctct tttaaataac gactatttga aagcacataa
    21601 tgaacttgta agagttcaaa atatatttac agaactaatg actacattag accaaaatgc
    21661 aggacaatgg gcaaaggata tgtataaagt ttatgaattt ataaaatctg aattagcaat
    21721 agctgatgaa aataaagata ttaaaataat tgatgatata ttgccaatag taaaacaaat
    21781 tagagataca tggcatgaag tttacaatca actaaaaata taattagatg gagggataaa
    21841 ggtatgtcaa gtataagtcc tataagagtt acaggtcttt caggaaattt tgatatggaa
    21901 ggcataatcg aagctagtat gattagagac aaggaaaaag ttgataaagc aaaacaagaa
    21961 caacaaatcg ttaaatggaa gcaagaaata tatagaaatg ttatacaaga atcaaaagat
    22021 ctttatgata aatatctaag cataaattct cctaatagta tagtaagtga aaaagcatac
    22081 tcttctacaa gaataaccag ttctgatgaa agtattatag tagcaaaagg ttcagctggt
    22141 gcagaaaaaa taaattatca atttgcagtt tctcaaatgg ctgaaccagc aaaatttact
    22201 attaaattaa attcaagtga acctattgtt cgacagttcc ctccaaatgc cagtggagcg
    22261 agttctttaa ctataggaga tgtaaatata ccaatatctg aacaagatac tacaagtact
    22321 attgtaagta agataaactc cctttgcgca gataatgata taaaggcttc ttatagtgag
    22381 atgacaggtg aattgattat ttcaagaaaa cagactggtt cgtcatcaga cattaattta
    22441 agagtaattg gaaatgacaa tttagctcag caaattgcta atgataatgg tatcacattt
    22501 ataaatgatg ctggtggaaa caaagtggca aatgtatatg gaaagaatct agaagctgat
    22561 gtaactgatg aacatggaag agtaactcat ataagtaaag aacaaaattc atttaatata
    22621 gataatattg actataatgt aaattcaaaa ggaactgcaa agttgacttc tgtcactgat
    22681 actgaagaag ctgttaaaaa tatgcaagca tttgtggatg attataataa actgatggac
    22741 aaggtctatg gtttagttac tactaaaaaa ccaaaagatt atccgcctct tacagatgcc
    22801 caaaaagaag atatgacaac tgaagaaata gaaaaatggg aaaagaaagc taaagaaggt
    22861 atacttagaa atgatgatga gttaagaggt tttgttgaag atattcaatc tgcatttttt
    22921 ggagatggaa aaaatattat tgcattaaga aaactaggta tcaatgaaag tgaaaattac
    22981 aataaaaaag gtcaaatatc atttaatgca gatacttttt caaaggctct tatagatgat
    23041 agtgataagg tatacaaaac actagcaggt tattcttcga attatgatga taagggaatg
    23101 tttgaaaagc taaaagatat tgtatatgaa tattctggaa gttcaacttc taaacttcct
    23161 aaaaaagcag gtatagaaaa aactgcttct gctagtgaaa atgtatattc aaaacaaatt
    23221 gcagagcaag aaagaaatat aagcaggtta gttgaaaaaa tgaatgataa agagaaaaga
    23281 ctttatgcta aatattcagc cttagaatct ttgttgaatc agtattcttc ccaaatgaat
    23341 tatttctcac aagcacaggg taattaatta tggataaatt aaaagaaaaa ttaaatttat
    23401 ataaagatat atctttacaa attataaatt tgattgaaaa ggaagaatat ataaagataa
    23461 gtattaagtt aggtgaaaga caagagatta taaatagtgt aagtgaaatt gatagaaatg
    23521 attttataca gctttataat agaatggaat taattgaaat tgatagcagg ataagagata
    23581 ttttacaagg acaattatta gaagtaaaaa aagaattaca tgagtataag cttactaaac
    23641 aagtgaacac aatgtattat aacttaaata gagaaaaagt aaatattttt aataaaaaag
    23701 tataaagtta tgtaccatct tgtccgatta tataaatgaa gaattaataa aaaagattaa
    23761 aagtagaaat gacaaggatg tcaactatac taaggagggt aaaataatga gagttaatac
    23821 aaatgtaagt gctttgatag caaataacca aatgggaaga aacgtaaatg cacaaagtaa
    23881 gtctatggag aagctatctt ctggtgttag aattaagaga gctgctgacg atgctgctgg
    23941 gcttgctata tctgagaaaa tgagagctca aataaaaggt ttagaccaag caggaagaaa
    24001 cgttcaagat ggtatatctg ttgtacaaac agcagaaggt gcattagaag aaactggtaa
    24061 catactacaa agaatgagaa ctttatcagt acaatcttca aatgaaacta atactgctga
    24121 agaaagacaa aagatagctg atgagttact acaattaaaa gatgaagttg aaagaatatc
    24181 aagctcaatt gagtttaatg gtaagaaatt acttgatgga agttctacag aaataagatt
    24241 acaagttgga gcaaactttg gaacaaatgt tgcaggaaca tctaacaaca acaatgaaat
    24301 aaaagttgct ctagtaaata cttcaagtat aatgagtaaa gcaggtataa caagttctac
    24361 aatagcaagc ttaaatgcag atggaacttc tggaacaaat gcagctaaac aaatggtatc
    24421 tagcttagat gtagctctta aagaattaaa tacatcaaga gcaaaattag gggcacaaca
    24481 aaatagacta gaatcaactc aaaacaactt aaataatact atagaaaatg ttacagcagc
    24541 tgaatcaaga ataagagata cagatgttgc ttcagaaatg gttaacttat ctaaaatgaa
    24601 tatattagtt caagcatcac agtcaatgct tgctcaagct aatcaacaac cacaaggagt
    24661 tttacaatta ttaggataaa ataattttgt atattggata tagaagaaag ggtaaggctt
    24721 tgctttactc ctttcttttt ttacaaatat acttttgaaa ggaaaattta tatgttactt
    24781 agtatagtta tgattgttaa aaatgaagaa aaaatacttg aaaaaacttt aaaatcatta
    24841 accacattaa gaaattctat agaaagtgaa cttataatag tcgatacagg ttctacagat
    24901 gatactataa aaatatctaa gaagtacacg gaaaaagtgt attttcataa ttggaataat
    24961 gatttttcta gtatgagaaa tatatcaata tcctatgcta aaggtgaatg gttacttata
    25021 ttagatgcag atgaaatact aattgattct tcaactattg taaaattttt taaagatggt
    25081 cttgataaaa aatttaattc tgcttcaata caattaaaaa atctttactc atatgataaa
    25141 aaattatatg gatattgttc agtgcttaga ctttttaaaa acgttgattt tagataccat
    25201 ggtaaagtac atgaacaacc aatatacaaa aaccctatat ttaataatgt tgctgatttt
    25261 gaacattatg gatatttgtt tgaagatgaa gaaataagat taaataaggt gaaaagaaat
    25321 gaaaaactat tatttcaaga gttaaaagag aatgataatt ctccatatac aaactatcaa
    25381 ttagggaaaa attttattat attaggaaaa tatcaggagg ctttatacta tcttgagaaa
    25441 tcttatgaat tatattctaa actagaattg gcacctggtt acttgataac aagccttgta
    25501 aaaacatatt tatatttagg aaaacataag aagtgtgaaa gattgtgctt aaagtatatt
    25561 aagaaagaca tgaataatat tgatatatat tattatattg cacaagcaca agtagattta
    25621 ggaaagtatg aaaatagtat agattcgtat aagagatata tttacttgtt agataattat
    25681 gaaataagta cacaagcaaa tagtttattt tcagacactg atactgtagg gcttagagat
    25741 gaggctatta ttacactgat aaagatttat tataagcttg aaaaatatga gtttgtaatt
    25801 tcagagtata ataacattga agatgtggaa aagaaaaaga atgtgtactt tagcttattt
    25861 atgtcactat ataaattgaa tagatttgaa gatataaaaa attattataa agaagtttca
    25921 aattctaaaa ttgaaaaaaa tagtttttat agaaatatag aagaagttat aaataatatt
    25981 aaagaggatg aaaaagagta tgtatataaa atcctttgtg acattgaagg taattatggc
    26041 attttaaatc aaataaggat aaataaatgt gtatctatag ataaatgtaa agaaatactc
    26101 aatgaagaaa aggaaataat ttatgcatat attataaaaa tagcttttga agagaagatt
    26161 gatttactag atatttttta tgaaatggaa tatgtatgga tagagaaata tctaaaatat
    26221 cttttagcat tagaaagaag ttttaattta gtactatata agtacataat tagtcgtcca
    26281 aatacatcag atatggaaaa gataagagta tataaagcta tatctaaagt agttttagaa
    26341 agtataagct taagtgatga aaaatataag gagatttttt atctttatat aatgtattct
    26401 tataagtaca taagatacat atatagcaat ttaagtgatt ttgaattaat aaaatttgtt
    26461 tgtaatgatt tagataagtt cactatagaa tttaagcatc tacttgatat taaaaataaa
    26521 gtaaataatg ctaatgaaaa attagagtat atacatagta tgaggaaatt actaaatgag
    26581 tatccttttt ataataaaat aataaaaata cttataggtg aattagaaga aaatataaaa
    26641 gaaagtgaag aatttaagga tttaaaagat agttttatta ttagtataga aaatatgatt
    26701 gaaactggca aaataaatga tgcgaaatta ttggtagatg actattcaaa aacatttgtg
    26761 gatgatataa agattttaaa tataaaggga attttataca tgtttgaaaa taagcttgat
    26821 aaagctgatt ttatgttaaa aaaggcatta tcattagatg tagaaaatga agatactata
    26881 tataatatag aatacttaaa aagtttaaga taagtcaaaa ataggagaat tgaagaatga
    26941 atataccaat agtggttaat gaaaaatcta aagacataat aaaagattgg caatatacat
    27001 gtacaaatga agatataaaa tttacaagca taataatatt gacatataat caaatagaat
    27061 atactaaatt atgtattgaa agtattagga aatttacccc aaagaataaa tatgaaataa
    27121 taataattga taataactct tctgatggaa cagttgagtg gttaaaggga caatctgata
    27181 taaaatctgt gtataataac aaaaacttag gatttccaaa aggatgcaat caaggtattg
    27241 agttagctac tggtgaaaac atattgttgt taaataatga tgtaatagtt actccaaatt
    27301 ggctctataa tttgaataaa gctttatggt ctcaagataa tataggtgct gtaggaccta
    27361 ttacgaatgc atgttcatat tatcagcaaa ttgatgttga ttataagtca attgaggaca
    27421 tgtttatatt tgcacacaaa ataaataaat ctaatattaa cctatggaaa tatagattga
    27481 agttagttgg attttgcatg ttaataaaaa aaactgttct ggataatgta ggggttttag
    27541 atgaattatt cacacctgga aattttgaag atgatgattt atcttttagg atgatagagt
    27601 caggatataa gttattatta tgccaggata cttttataca ccattttgga agtgtgtctt
    27661 ttaaagaaaa tcgtaataaa tatacagata taatgtatat taatagaaga aaatttgaaa
    27721 ctaagtgggg atttaatcca gaatatagtg gaatgataag aacagatttg atttctaaaa
    27781 tagatgatag tttggaggca aatattaatg ttttagaaat aggatgcggt ataggggcta
    27841 ctcttttaga aataaaaaat atatataaaa atgcatcaat atatggaata gaaattagtg
    27901 agtcagcagg taaacttgca aagtatagtg cagatgtact tatagcaaat atagaaaaag
    27961 taaaattgga ttataaaaaa gatttttttg attatataat attgggagat gtacttgaac
    28021 atttgattga cccatggaag atagtcaatg aattgaaaca atatctaaag aaggatggtt
    28081 atctggtatc tagtatacca aatattatgc atgtttctgt tttaagaaat cttgtgttag
    28141 gtaattttac atatgaagat tcaggaattt tggacaagac tcatttaagg ttttttacat
    28201 taaatgagat aacaaaaatg tttaatgata gtaattacat aattaatagt attacagcta
    28261 ctagtatgcc actttcggaa attgataata gcttcattga tacaatatgt aaggaaagct
    28321 gtaaagaaat gagacaacag tacgaatctt atcaatatat agtaaaagcc tctaaaatcc
    28381 tagatactaa aagatattct agtattagta tgattaattt aaaatacgct ttaatgagaa
    28441 ttgataatga attagatgta gatagtaatt taagttatat atttgataat tataatataa
    28501 ctgaaccatg ttttgttgat gatattgaat atctaattga tacatttgtg ataaataaag
    28561 caactctatt aaatagatta ggagttgagg catttaacag aggtctagga gattttagta
    28621 taaacatgtt tatgacagta ttagagatgg atagagatga tattgactca atatataata
    28681 taacaagtgt attatgtgaa ttagaagaat ttgatactgc ttataattta attaaaaata
    28741 gtagcgaaaa agtacagagt gaaagtgata tacaagagat actttgtttt attgagggga
    28801 agaaatatga ataatgataa gatatgtttt ataacctgtg taaatgatga aaggctttat
    28861 gaagaatgtc ttgtatatat aaatagccta gacattccta aaaactttag tatagaaaca
    28921 gtagctttaa gaggagccga ttctattgcc tctgcttata ataaagctat gagagaaaca
    28981 gattctaagt ataaggtata cttacatcaa gatactttta taattaataa aaatttcata
    29041 catgatattt tagagatatt taaaaaaaat acagatgtcg gaatgattgg tgtagctgga
    29101 gtaaaagata tgcctgtgaa tggaatttgg tgggattctg ataaaaaagc agggaaagta
    29161 tatgatagtc atacaggtaa aatggatatt tatgaattta gtaactttga agaatgtttt
    29221 aatgaagtta tggctataga tggattaatt atgattactc aatatgatgt attttggaga
    29281 gaggataagt ttgatgggtg gcatttttat gatttgtcac agagtatgga gtttagacaa
    29341 aataaataca aagttattgt accaaaacaa aataagcctt ggtgtatgca tgattctgga
    29401 gtagtaaata taaataatgg atatgatgaa tataggataa aatttgtaaa agagtacata
    29461 aatcttgatt tatatagaga aaatttttat gaatttgata agaagaaagc aagtaccata
    29521 cttaagagta ataagcatgt aatggattgt atgaaagagg agcttacaga acaattaaga
    29581 ttaaagaatt acaaggatgt tttaggtatt gtttctaaaa ttgctcattt ttctgttttt
    29641 aatcatactg gtttgtattc ttgtgaagaa tgtgagagag cattgctaga atgtgcaaat
    29701 aatttaccag aaatagaaaa tacgaaatta tttacaaaaa aagatttaaa aagaagaaaa
    29761 gtattacatg ttttaagtga aggatattca acaggaggtc atacaagact agttaaaaat
    29821 tggattgaaa ttgacaaaga ctctgttcat tcagttgtaa ctacatggca atcagataca
    29881 ctgccagact ggttattaaa agcaataaat gatagtggtg gcgaagttat atctttggat
    29941 ttaatttcag atgattattt aaaaagagct gtagctttga ggaaaatagc ttatgactgg
    30001 gctgatatag ttattttata tgttcatatg tgggatacaa tacctgttgt tgcttttgga
    30061 gttgatggga aaatacctat tttacatgtt aatcactatg atagtacttt ttggttaggg
    30121 acaagtattg cagatattgt cattgatttt agcgaagcta gtcaattaat tacattagat
    30181 aaaagaggca tagataaatc tgaaatatta ccaatgccat taaaagaaaa agaagtattt
    30241 tcaaaatctg aagttagaaa acgatataat ttagaggatg atgtgacaat aatattgact
    30301 attgctagtg aaagaaaata caatagtgta aatgatatta attactttaa aattgctaaa
    30361 acattgattg aaaatacaga taatacaatt attattgttg taggagttga tacagagaat
    30421 ctctattgga aaactttaag taacgttaca gataatagag ttatatgttt tggaacaaca
    30481 gcaaatatag acgattttta caagatttcg gatatatata tggagtcttt catggtagga
    30541 agtcatactt caaaactaga tgcaatttta tatgatttaa ttcctgttaa gtttaaaaat
    30601 gaagtttcac caatttttac aaatatgtgg aattttatag ataagtttga ttataagaat
    30661 ataaaagagg ttatagatat gataaaaagg tacaatacta gtgaatttga cagggatagg
    30721 ataaaagaaa aacaatcgga aataaaacat tttgttatag ataaacactg tattgaaata
    30781 aaaaactata tagacaaaat atataatgaa gctaatcatc ataaagttaa gtatgattta
    30841 tataaaaatg atgaaatcga ggactatcag ctttttgtag cattatatgg ctatatggta
    30901 aaaaataaaa acatgtcata ggtggtaaaa tgaacaatat tcatatcaat aaatttgaaa
    30961 aaagctgtga aagaaactgg gattattttg tagaaaataa atctataaat ggtacatttc
    31021 tgcaaactag aaatttcctt aattatcatg aggagggaaa attcactgac cactcattaa
    31081 taatatgtaa aggtgaagaa atactagcag tcgtacctgc atgtgaaact tatgaagatg
    31141 gtgaaagaat atttttttct catttaggga gtacttttgg tggtattata ataagaagtg
    31201 gttttaatga tattaggcat gtaaatgcca ttacaaataa gttagaaata tatttacggg
    31261 aacaaaattt cgataaagta tatttaaaaa atacatcaag aatattttgt aaagaggata
    31321 cttcattact agaatatttt ttatttaaga ataattacat gttttatgat gaattaagta
    31381 tgtttttaga attaagtaag tataaagaag atatattagc caattttaaa tacagtaaaa
    31441 gaagagattt taaatattct ttgaagaata atcttacctt taaaagactg tatagtgatg
    31501 aagatatagt ttgttttttt aatttacttt ctaattgttt agatagtaaa ggagctaaag
    31561 taatacattc agtagaagaa cttttggagt ttaaaaataa tagattaaaa gatattgtag
    31621 aattttatgc agtatatatt gatgacatta tgatttgtgg gagcatggta tttaactttc
    31681 aagaaagagt ttatcatact caatatctag catcaaattc gacatataat aaatattatc
    31741 caatgatatt tttatactat aatctaataa aagatgcttt agagagaaat tttaagtatc
    31801 tttcttttgg aattagcact ctaaatagag gcaaatactt agacgagggt ttagctacat
    31861 ttaaagaagg ttttggttca agtgcaattt gtaacagaac atactataaa aatataaata
    31921 agtgagaatc atgttttata gagtttttag aatatagtaa atatctagta ctctaacatt
    31981 acataaaaat aattagttta taaagaaggt ttgtatatga aaagattaat gattttaggc
    32041 tcaattaagt attttgagaa tattgttata tcagctaaaa aagagggaat atatacgatt
    32101 gtttgtgata atagaattga tactcctgcg aaaaagattt gtgatgaagc aatagatgtt
    32161 gatgtatttg attttgataa aataaaaagt atagctatag ataaaaagat agatggaatt
    32221 ttaactggat ttacagattc tttaatgaaa ccatatgttt atattgcaaa tgaactaaat
    32281 ttaccatgtg tgatttcttg caatcaactt gaatctgtaa ctaacaaggc tattatgaaa
    32341 aaatatttta aaaataatgc aatacctaca actgattact gtattattga aagtctaaaa
    32401 gatttagaaa aaatacaagg attaaatttt ccacttgtaa taaaacctgt tgatggttat
    32461 ggttcaagag gtgtatattt tgtatcaaat atagaagaat taatagaaaa atttgaatat
    32521 tctaaggaag cctcacaaga tggacaagta ataattgagg aattttatga aagtgaggaa
    32581 atacaaggac tagcttgggt tcataatgga gagtcacatg tattttatat tggagataga
    32641 gagcttgtaa acatacatac aggaagagct ggaaaaccag atagattact ttatccatca
    32701 aagtattgtt ttcaatatga ggaggaaata aaatctatat atcaaaatat aacacaggct
    32761 tttgatataa aaaatggacc tctttatgta caaatgttag tgggagcata tggaataaag
    32821 gtatctgaag taatgccaag attacctgga ggttgtgact atatggctat ttctcaaata
    32881 acagatttag acataggaag tttatttgca aactttagtg tgaataatga agtaaatttt
    32941 gatgaaataa agaaatataa tatgcatcta tcaaaatgtg tatatgcatt accaatatac
    33001 ataagacccg ggacaataaa aaagataaat aatatagata aaatagaaaa cttagattat
    33061 gtcactcaat ttctattact agtaaaagaa ggagatacaa tagaattata tgaagatgag
    33121 agacaggatt gtggaagagt ttatggaata gcaaataata tatttgatgc aaatataaaa
    33181 aagaaatgta ttcatgaaat gatagaaata cttgatgaaa ataatgaaaa tatgatagaa
    33241 aatttttaaa taagggagta tgatagatat gaagctaata actcatgaac aaattatgtc
    33301 attaaacatt tctcagaaac aaggatatga gtggataaaa gaatctttct taacaaaaaa
    33361 agattgtcaa ttaccaccaa aaataagcat ggtagaagaa ggacatgtat tttacaatgt
    33421 aatgccatcc ctaaatcata atcatatgat tggtggaata aaaatggtta caagattgcc
    33481 agggagaaat ccaagtttaa actcagagat atttctatac aatatggaag atgctaaatt
    33541 aaaggctatt ttggatggta attatattac agcttttagg actgctgctg ttgctgcctt
    33601 ggctatcgat acatttgcta aaaaagattt taatactatt gctattatgg gtttaggtgt
    33661 aactgcttct gctataatga atatgctttc atatactctt aaagataaaa atataaatat
    33721 aaagttactt aaatataaag accaagcaga gttgtttgta aaaaagtatg aaaaaaatga
    33781 acaatttagt tttgaaatat gtgatacaca tgaagaactt attgtagatt cagatgtagt
    33841 tatttctact gtgacatata cagatgaata tttatcagaa tttaaatggt ttaaaaaagg
    33901 tgctttatta ttacctgtac atgttatggg atttggaaat gttgattatc tatttgataa
    33961 agtatattta gatgattata atcatttgaa acatctagaa aatatagata gatataaata
    34021 ttcttgtgaa ttttatgatg ttttaagtaa acaagctaaa ggaagagaaa atgatgatga
    34081 gagaataata tcttacaata taggtttgtc aatacatgat atattatttg caaataaaat
    34141 ttacgaattg tgtgaaacac taagctgtga agaaatagaa ttaaaagaac caaaagaaaa
    34201 atattggata tagtttattt cattcatatt tacaatagtt tattgtaaat atgaatatga
    34261 agtaatatat tgttagaaaa ttagcatgaa taggatagat aaatttatgg ataaatataa
    34321 tttaattagg ttcgtatcta ttggaaacga atatatagga aatttagttg cattagaatc
    34381 aaataaagta ataccttttg atataaagag agtttattac atatatgatg taccaaacaa
    34441 tgtaaagaga ggatttcatg cacacaaaaa cttggaacaa gtactagttt gcctaaatgg
    34501 aagtgtgaag ataaaatgtt atgatggtgt aaaagagact atatttaatt tacataaaaa
    34561 tgatgttgga ttatatatag gaacgggagt gtggcatgag atgtttgatt ttgatgaaaa
    34621 aactgtttta atttctatag catctgaaca ttataatgaa gaagattata ttagagacta
    34681 taaagaattt ttaaagtatt taaataatgt gtagttatta tacaattagt gatgtatttt
    34741 cttaattaaa taaatttaag atagccacat agagaataga tagattagga tgtgaattta
    34801 ttgttggtta aatttaataa tttattaaaa cagttccaaa ctcataaaga agaatatgaa
    34861 cagaagatta aggatgtaat ggaaagtgga tattatatcc ttggaaatga agtaaagcat
    34921 tttgaagaag aatttgctaa ctatgtaggt agcaaatatt gtgttggttt agccagtggt
    34981 ttagatgcac tgataattgc ttttagagca ttaggaataa gcaaaggtga tgaagtaatc
    35041 gtgcaatcaa atacatatat tgctagtgtt atgggaatca gtataaatgg agcaacacca
    35101 gtatttgtag aaccaaatga atattataat atagattcat ctaagataga agaaaagata
    35161 aatagcaaaa caaaagctat attagtagtg catttatatg gtcaagcaag taatatgaaa
    35221 gatatacaag aattatgtga taagtataac ttgtatttaa ttgaagattg tgctcaatct
    35281 catggagcta aatatgatgg aaaaatgaca ggaacatttg gtgatatagg ttgttttagt
    35341 ttttatccaa gtaaaaattt gggtgcattt ggagatgcag gagctatagt aactagtaat
    35401 gaggaaatag ctgataaagt gaaaattctt agaaactatg gctcagaaaa gcgatattat
    35461 aataaatttg tcggatataa ttcaagattg gacgaaattc aggcaggttt attaagagta
    35521 aaacttaaat atctaaatga aattgaaatt gaaaaatcaa aaatcgtaga tagatatctt
    35581 aatgaaatta ataatcccaa agtcatactt ccaaagatag aaaataattg tactcatgta
    35641 tggcatttat ttgttttaca agttgaaaaa cgagatacat ttatggaata cttaaagaaa
    35701 agtggtatag agtctataat acattatccg ataccaccac atctatctga agcatatgct
    35761 tatttgggat ataaaaaggg gagttttaat atagctgaga actattcaga taaagttgtt
    35821 agtatacctt tatttattgg tatggaagat gaagaagtta gttatataat taaaattata
    35881 aatgaatatt aaactactca taataatatc aaaaataaat tttttatata tcatttattt
    35941 aaatttcgtt aattgacatt tttaaatatt gatatattgt acaaataaaa ttgaaatata
    36001 tggaaaaata tagaattaag atgagatttg tcttatattt ttataaatta aaaatatttt
    36061 caaagagttt attataaaat tgtaaactat agtgtttata atctttgtaa ttattggtaa
    36121 ttaaatttaa aaaataaaat atttaattat acacaaaaaa gatatttaaa aaatttgtta
    36181 tttattgtat acttaagtta aaactaaata ggcaaatcta gagaaatcta gtgacgcaaa
    36241 gctataggga ctaaggttta tatacataaa ctatgtcagc cagttgccaa aaagagtcct
    36301 aggtgtattg tatacctaag aaaagtctat aatgactgcc tttttggcag tcattttgtt
    36361 atggaaaaat cactttattt cagtagaaaa tacacataat aacatatttt accaattata
    36421 acataaaata aagaaaaatt atctcaaaaa gttactattt tacaaaaaag agcaactttt
    36481 cgaagaaata tttaaataca tattaaaatt tttttatatt ttcatgggac ttcattaaaa
    36541 aaatattagt tttcttacta aattgataca ttattgtatt aatgtaatgg aaatgcgatt
    36601 aatttaaata aataaagaag tcattttttg taatatagca acttcatttt ttttattaat
    36661 aaacaaaata gataaaatat attttgagga ggggtgagtg tgaatacata tgacattata
    36721 aaaatgggat tagatgcaac taatctaaga agtcagacaa tagcaaataa tatagcaaat
    36781 ataaatactg aaggatataa aagacattat ataacttttg aagaaacact aaatgatgct
    36841 atgcctaaaa tagaagaaaa aacagacaat tctaaaggtt taagagtaga tggtaataat
    36901 gtagacatag aagaagaaaa agtaaatcaa gcaatggcaa cattacaata taatgctttg
    36961 ataagttttg caaatggaaa aatagcaatg accaaatcaa taataagtgg gaggtaatta
    37021 gaagatgagt gtgttcagtg gaatgagaat atctgctagt ggattaacag cagaaagttt
    37081 gaaaatggat atcatatcat ccaatgtagc taatataaat gctacaagag gtccaaatgg
    37141 agaagcatat aggagaaaag ttgtttcatt tgaagaaaac tatgataata aattaggtat
    37201 gctaggagta aaagttacat ctgttgaaga tgataaatca cctcttaaag aagtatatga
    37261 cccatctcat ccagatgcaa agccaaatgg atatgtagaa tatccaaatg taaatatatt
    37321 ggtagaaatg acagatttaa taacagcttc acgagcatat gattctaacg tagatacatt
    37381 gaatgctcag aagtctatga tatcaaaagc tttggaaata ggaaagtagg gataaattat
    37441 gccaattaca caaattaaca atttaatgca aggtgcaaag ttagataatt tgattggaga
    37501 agcaaagcca ttaactctta ataataaaga agaaaaaaag aattttgaag atgtaataat
    37561 agatactata gataaagtta attttcaaca agtaacagca gatgatatga aagaaaaatt
    37621 tataaaaggc gaagatgttt ctatgcatga agttatgtta ataggtcaag aagcacaact
    37681 atctatgcaa tatttaatag aagttagaaa taagattcat gatgcatatc aagaaatgaa
    37741 taaggtgcaa atttagcctt ttgaacagga gtaataatca atgataacca gttttaaaaa
    37801 taagattaag gagcaagttg ctaaatctag gacaaagata agttctttaa aaaagggaac
    37861 taaaatagca ttaggtatag gggttattgc tatatgttta gcgctagtat ttacagcaat
    37921 atctgcgagc aaaaataagt atgcagtctt attttcagaa ctagatgctc aagatgctgc
    37981 agatatatca gcagagctag agtctaaaaa gatagatact aaggtaaaag gaagtacgat
    38041 ttatgtacct agaacagaag ttgataagtt aaggctggag ttagcgccaa gtcttacagg
    38101 tggttctaaa ggatttgcac taatggatga tagttcatca atagggctta ctgatgaaga
    38161 atttcagatt aagaaacaaa gaatgataca aggtgaaata gaaaaaacaa taaagagttt
    38221 tccacaagtg gaagacacta gagtacatat aacatttgga gagtcatcag tatttgagaa
    38281 ggaggctgtt ccagggagtg cagcagttta tttgatgcta aaaccaggga cgactttaga
    38341 aaaaaaccaa ataaagtctg ttatggcact tatatcagga agcgttacaa atataccaga
    38401 gaaaaatgtt caggttattg ataacaaaat gaatttatta tctgaaggta ttttggagga
    38461 tgaaaatgtt gatgaaaata atcaaccaat aaatagtggc attagtgttg ataaaaataa
    38521 ggcatctgaa caagcattga ataaacaact agaaaagtct attttagaaa tgctagaacc
    38581 gatatttggt aagggaaagg tgaaagctac agtaaatgct gatttaagtt ttgatacagc
    38641 tgaaaaaact gagataaaaa ttgaccctga taaagttgca ataaaggaga caaggtcgaa
    38701 aaattcatct aaatctgctg caaataatgt tcaaggtgta gatgctaaca tgaataacca
    38761 aggaaataac aatggtacta atacagaaga tagtttagat gagagttttg agtatgaaac
    38821 aggtaagatt gaaactcaca ctatagttgc gcctggagaa cttaatagat tgacagcttc
    38881 tgttgcaata gatggaaaaa tagctaaagg tgttcaagct gatgtagagg atattgttaa
    38941 taatgctata ggtatggatg gagcgagggg agatactctt agcgttgttt caatggtatt
    39001 tgacccagaa ggtaagaaag aggctaaaca agagctggaa gagattaaaa aagaaggatt
    39061 taaaaagaac ataataaaag cagttattgg agtagtagca gtaatagcag ttggagctat
    39121 tggatactta atatataaga aaagaagtga acgagaagat atggattatg aagatgaaga
    39181 ttatatttct aaatctgatt ctgttgatag gaaggataat cctctattag gagatgaccc
    39241 agaactgaca ttagaggaag ctgttaaaat gtatgcagaa gaaaagccag accaagtaac
    39301 agagataata aagacttggt taaatgagta agggggatag aaagtgtcca cggaaattac
    39361 aaatgttaat gcgtttgact taagtgatat aaatgaaagt gataagaatg agaaggtaga
    39421 aggtgagggt ttaaaaaaag ctgctgtatt attaatgaca ttaggcccaa atgtgtctag
    39481 tgatataata aaaagcttgc ctgataaaca agttcaaaaa ataggtttgg aaattgcaaa
    39541 tatttcttca atagcttcaa aagaaagaag agaaatctta aaagagtttg tagaaataaa
    39601 tagggcaaaa gattatgtta tagaaggtgg gcttgaatat gcaagagagt tattaagtaa
    39661 tgctttagga aatgttaaag caaacaaatt acttgaaggt atatcaataa atacaagtac
    39721 aaagcctttt aaacatatta taaaactaga tgtaaagaag atattagaaa tacttaggaa
    39781 tgaaagtgca caaactatag ccgttttact tgcacatatg gaaccagaaa atggagcaga
    39841 agttttatca tacttagatt ttgatttaca aaatgaagta gctatgagaa taagctcaat
    39901 gggttcaata tctccagaag taataaaggt aattgaaagt tcattagaag ataaattaca
    39961 ttcaataagt ggtgatgatt ttaatgatta tggaggggtg tctaccttag ttcaaatatt
    40021 gattaattct gatagaaaaa cagaaaagaa tattttggga actattgaag aacaaaaccc
    40081 ggatttagca gctcaaatta aatctcatat atttgtcttt gaagatattg tcaagttaga
    40141 tgatataagc atacaaaaag tgttaaaaga agtgactatg aaagatttag tatatgcctt
    40201 aaaaggtgta gatgatgaga tttcagatgc tatatataga aatcaatctt ctagagcagc
    40261 agatgcactt aaagaagaaa tggaaatggt tggtgttata aaggttacac aagttgaggc
    40321 ttctcaacaa aagatagcta atatcgtaag aaaacttgaa agagaaggtg ccataactat
    40381 tgtaaggaat tttggtggtg actttgttga ataataagat tattaaaagt aaaaaagcat
    40441 tatataaagg agtgctagat ttaaccataa tagataaagt tagagtggga gaatcaaatg
    40501 taaataaaga aaatgattgt agatttaggg atgaggtaat aaaagaagct atagaatctg
    40561 ctgagataag aaagaatgag atattagaag aagcaaaaat gaatgcacaa aatatagaaa
    40621 agcaagcata tgaaaaaggg tatagtcaag gtcaaaaaaa tggatatgaa gatggatata
    40681 aagagtcata tgatgaatat acccaaaaag ctaaagatga agcagatttt ataaaaaatc
    40741 aggcagactt aatactatta caagctaatg agaagatgac tgagtacata aaagaaaaaa
    40801 ataaagagat tgtaagactt gctattaata tggctagttc tgttctaaaa aagcatttcg
    40861 aagatgaaga atctatgagt gatttgttaa agcaaattat tcaagattat gaaggaagta
    40921 gttcatttat agtaagatgt aattctttct ataaagataa tatagagaaa gagtttgaat
    40981 tattcaaaga ggaaacatca ctaaaatcaa gtgtatttgt tattgcagat gatagtatag
    41041 ataaaggcaa tgctattatc caaaaggaaa atggaagaat aatagttggt attgattgtg
    41101 ctatggaaaa actaaaagaa gaattgcttg gtgaataaag tatgtataaa actgatatat
    41161 ctatagattt tgacaaaata aataagaaaa tagaaaattt agaactcact atatcagaag
    41221 gtagagtaaa gaagataata ggacttactg tagaagttga aggaataaaa gcttttgttg
    41281 gggagttatg cgttatatac aaccaagtta ataaaccagt gaattgtgaa gtagtaggtt
    41341 ttaaagataa agaagtcata ttaatggcgt tgggagaatt aacattgata gcacctggtt
    41401 gtaaagttat ttctaagggg atacctttaa gtgttatgtg tagtgataat ttactaggta
    41461 aagtacttga tggtcttgga aatcctatag acaactcaga tgctgtttta ggagatagat
    41521 acaacctgaa caatgaacct cctgacccaa tgaagagaaa aaagatacga aatataatgg
    41581 aaacaggtgt aagagcaata gatgcattta ctacttgtgg tgaaggacag agaatcggca
    41641 tatttgcagg aagtggagta ggtaagagta cgactctagg tatgattgct aggaatgcaa
    41701 aagcagatgt aaatgtaatt gctcttattg gagaaagagg aagagaagta ctagatttta
    41761 ttgataaaga tttaggtgaa gagggaatga aaaaatctgt tgttgtgtgt gcaacatcag
    41821 ataaagcccc tctagttagg ttaaaaggtg ctcttactgc tactgcaata gcagaatatt
    41881 ttagagacca aggcaaaaaa gtaatactta tgatggattc agtaactaga tttgctatgg
    41941 cacaaagaga agttggtgta gcaataggag agccaccagc tcaaaaagga tatacaccat
    42001 ctgtatttgc aatgttgcca aaacttatgg agagaacagg gacatcagat aaaggttcta
    42061 taactgcatt ttatacagta ttagttgatg gagatgactt taatgagcca atagcagata
    42121 caacaagagg gatacttgat ggtcatatag ttttatctag agacttggca aataagaatc
    42181 actatccttc tatagatgta ttaaacagtt taagtaggct tatgaatgaa attgcttcaa
    42241 aagaagacat aaaaatagcg tcttttgcaa gagacatgct tgctgagtat agagaagcag
    42301 aagatttgat aaatataggt gcatatgctt caggtacaaa caaaaaaata gatgaagcaa
    42361 tctattatca tgagcatatt attaattttt taaaacaagg aataaatgaa aagagttctt
    42421 ttaatgaaac tataagtagt ttaagaagaa tctttgaata aacaatttaa aaaaatattt
    42481 gaataggttg tgatggaatt ggataaaaat tttaagttta gattacagaa agttttagac
    42541 ttaaaaataa aagatgaaga agagataaaa atggaatttg ctaagattca acaaaaaaaa
    42601 atagatatag aaactaattt agaaaactta gaaagtaatt acagcaaata ttctataagt
    42661 aaaaataatg ataatgttca aaatcaaaaa ataactatta actatttgct agctttaaac
    42721 aactctataa tggatttatc agaagaactg gataagtcga caaatgaact tgaaaaagct
    42781 agaaaacagc ttataagcaa acagatagag agaaagtcat tagaaaaatt aaaagaaaaa
    42841 aaatatggac agtattataa agaagaacag ttaaaagaac aaagcactaa tgatgagttt
    42901 gcaagcatga gttatttgag aaatagacaa gttctataaa ataataggaa gtgaggatat
    42961 tattgtatga agatacaagc agattcttat aatattatta aagatattgg gaatagaaaa
    43021 aactcatcta agaataaaaa tataaaaaat aataaatttg aagataatct atataagaca
    43081 acagaccata aaaatgttaa agatagaaga gaaacaagta agcaaaatgt tagttcagat
    43141 agaccgggaa atagtgataa tgagtgtcat ttagatgaag ataaaagtaa tcacttagaa
    43201 gatgaaaata catatgaaaa agattgtagt aagaataatg aagctttaca gcaattactg
    43261 aatcttttaa aagagaatta taaaaaagat aaagatataa acactatatt gaataatata
    43321 aaaaaactaa gtatatcaga tgaattaaaa caagaactta agcttaataa aaatatattg
    43381 aataaaattg caaatcaaaa tttagagtta aatggagcta atacaaataa ccctaatgat
    43441 atagaaaatt tagacataat gaagttaaga gaacttttag aaaataatgc tagtgaagat
    43501 attcaagtaa ttagtaaaac tacagaaaat gatactaaaa gcatagactt atacagtttt
    43561 gatagtaata gaatggatac tcttaactca aataaacaga aagatgatag ttctgatatt
    43621 ttggaaaaac tagcagggtt aaatggaaat aagagtggaa attttggaca agtaataaat
    43681 aaaagcgttg atatgaataa aattaaaaat gataatgtta atttaaaaca gatagaatct
    43741 aatgtaatgg atgattctat aaaagctatt aagcatatga aaacaaatga tatacaagaa
    43801 ttgacaatta aattaagacc aaaagaatta ggagatatga acatacaatt attaaaagat
    43861 ggtgaaagta tgagagctgt tgtgactgtt ttcaataaag atgtctttga ctctataaat
    43921 aaaaacatag cagatttaaa gcaacatctt gaacttacaa atgtaaatat aaaagatgta
    43981 tcagtgcaaa tgcatagcga taatacaaat acatctgata cctttgataa agcatttgaa
    44041 caacagaata gacaaaataa ccaagaaaac atgagtaatc aaaatacaaa tgataagcgt
    44101 aacaatgtag tcatagaaga tgagattaaa gaaaatatta ttgatgatga tagagtagat
    44161 ttactagctt agtaaggggg aagtattgca tgtacggaat agcaacggct ttggcaggaa
    44221 ctcaggtaaa ctataggtca aataacttaa gccaacttga aagaaatatt aatgatattg
    44281 ccaacaaaca agttagaagt aaaggaaatc agacagtaac agacaatggg actccaatta
    44341 taggacaagg tgatgatgct gataaagact tgtttatgaa gattcttgta gcacagatgg
    44401 gtaatcaaga cccaatgaat ccacaagacc caacggagta tgtatcacaa ttagcacagt
    44461 ttgcaacttt agaaaaaatg tcagctatga atgataagct agatatactt ttagccttaa
    44521 gtaactctac tctaataaac tctgctttga gtatggcaac atcattaatt ggtaaagaag
    44581 tagaagtatc tggggaagaa gatgaagatg aaaacattgt aggagtagta aagtccacat
    44641 acataaaaga tggggaagta cacttagaat tagaagtaga tggaagtgac aaaactgtag
    44701 atgttaaata tgaaaaatta cttaaaatag gagaggtaga ggcaaattca ggagaagaaa
    44761 atgactcttc agaacaagaa tctccagaag aagtataata ttaaatggga aaagaggtaa
    44821 atttatgata aaagcaatgt attcaggtgt aagtggaatg aaagcaaatc aaacaaaact
    44881 agatgtaatc ggtaacaatg tagccaacgc tggaactact tcttttaaga aaagttcagc
    44941 tagaataaca gattcatttt atcaaactgt actatatgca agtgctccaa cagcggcatt
    45001 agggggaaca aacttaggac aagtaggtgt aggtagtaag atatcaagta taaacaaaga
    45061 tatgacacaa ggaaatgtac aaccaactaa tagaccatct gatttaatga tagatggaga
    45121 tggatatctt ccagtagtaa gacaaggaac agttatgtat acgagagatg gttcttttaa
    45181 tttagataca ggatttaaag cagctgatgg tgctttgaag aatattaaag gtggaagact
    45241 tgtaaatggt gatggatata tgttacaagg tatgatttat gatggggaat ataaagctga
    45301 tactggagaa tttgttaaaa agggtgatgc taaaggaaaa gagcctattg taataccact
    45361 tcaaagtata agtcctaagg atggaacagt tcaaaatgta ctagagtata atatatcaaa
    45421 ggatggaaca gtagaatttt tattgagtga tggtcaaaga actcaatttg tctatgatat
    45481 acctgatggt gctaaggtag gagatacacc tgctggaata gataaattaa aaggtacaat
    45541 acaaaaagtg caaacatatg cattccaaaa tccagcagga ctagatgcag aaggaggaaa
    45601 cttgttcaag ccatcagcaa actcaggaga cccacaaata gcaggagcta caggcacaat
    45661 aatacaagga gctatagaag cttccaatgt agatatagca gaagaattta cagaaatgat
    45721 aatagcaagt aggtctttcc aagcaaacag taaaataata tcgacatcag acgaaatact
    45781 tcaagaaata ataaatctta agagatagta ggtacatatt atgataagag taacggattt
    45841 aaacggaaga aaatacatat taaattcaga tcttatagtg agaattgact ccgtgccaga
    45901 aagcaggatt ctccttacaa caggagaaaa aaatcttgta aaagagtcag tagatgagat
    45961 agtagataaa gtaataaagt ataaaagaaa aataaatgta ggttatatta ggagtgaaaa
    46021 ataatgaaaa aaacagattc actaacattc attggactaa tattatctac agtattagtt
    46081 ttatttggag cagtaaaagg aagtagttca ggattgaaaa gttttttcga ttttgcatct
    46141 atattaatca cagtatttgg gtcatttgga gctttgatga ttacatttac tattgacgat
    46201 ataaaactta taaaagatgc tctacaatac tcattcaaga caatgaatat atcgaaatta
    46261 gacttattaa atcaatttaa aacactttct aaaaaagcaa gaagagaagg acttttatct
    46321 atagaaagtg atgtaatgaa aatacaagac ccatttatga aaaaaggatt agagttatgt
    46381 attgatggtc ttgaaataaa tgaaataagg tctatactag agctcgaaat agattctgtt
    46441 gaagaaacca ataacagata ttctaaacta tttaaaactt gggggacttt cgcacctgca
    46501 tttggtatgt tgggaactct aataggttta atacaaatgt tatccgacct tacatctcca
    46561 gatttaatag catctggtat gggaaaagca ttaattacga cattttatgg gtctttactt
    46621 gccaatatcg ctttgaaccc aattgcatat aatatagatg agaagactga aaaagaaatt
    46681 tatgtaaagg aaatgatgct ggaggggata ataagcatac aatctggaga gagcagcata
    46741 gtagttgagg aacgtttagc tacatacctt tcaaataatg agaagttaga aattatgaaa
    46801 tccaataaaa atacagaaag agcaatgagt aatggcgcgt aaaaaaaata agaaaaagga
    46861 tgagataaat ccagatgcat ggttggctac ttatgcagat acgataacac tgattcttac
    46921 attttttgtg ttattgtatg ctacatcagt tgtagatatg gaaaaattta aaaatatagc
    46981 agatgcgtta aaaggtcagt tttctgggac aagtatgttt agtacaggtt caagtacaag
    47041 tgagaaatct ccaatagaga gtgttttagt ggataaaaat gataagtcaa atttagaaca
    47101 ggatttaaaa gataaagtta ataattctaa cttacaaaat agtgtaacag tcaaagatga
    47161 tagtagaggg attttactag agctagatga ttcaatttta tttgactctg ggatttctga
    47221 attaaaagaa gatagtaaag ccactcttaa taaagtatac gatatgataa agatgatgaa
    47281 aaataagata gttatagaag gccatactga taatgtacct gtaaaatcaa gtacgcatga
    47341 atccaattgg gatttatctt ctagtagagc agtaagtgtt gtaagatact ttgtagaaga
    47401 aaagggcatg gaccctaaac tattttcggc aacaggatgt ggagagtacc aacctttggt
    47461 atcaaatgaa acagcaaagg gaagagctga gaatagaaga gttaatatac ttataactat
    47521 tgactaggag gaagaggttt gttcaaaaat aaaaaaatta ttataattat tttgatactg
    47581 attattttct cagcaggagc aggttttttt atattaggag aaggtggaaa taaacaaatt
    47641 gacaagattg caggtttgtt tattccaaca gggaaaggca aagatgaagt aaagaccgaa
    47701 aatcttgact tagaagagat ggtattgaag ctagctgatg aaggtgtaag atatttaaaa
    47761 gtatcaataa ctgtatctta tgattcttca tataaagata tagaaaaaaa tacgccttta
    47821 attagggata atattataaa ttgttttatg gcaaaaaggg cagatgattt tactgctgat
    47881 aatttaaaga acataaaaga agaaattaaa aatacattaa atatacaact aggtgaaaat
    47941 gtaattcaaa atatatattt cacaaatata gtagtgcaat aaaaggatgg taagacatga
    48001 tactttattt actaaaaata ttaatatgta tcccaataat tttaatattg atagtcttat
    48061 ctttaaaaat tagccaagga actttattaa aaaaatataa tgataaatat ataaaaatac
    48121 tagatattgt aaatataagt aaaaacaata gcataataat tttaaaaata ggtgaagaag
    48181 gatgcattat ggcatcttct tcttctagca tgagtaaaat aaaagatttg accaaagaag
    48241 aaatattaag aatagaaaac gacattaaag aaagaaattt taaaattcaa gattttaaaa
    48301 tggaaagaat taaaaagaaa tatgatttca gtagatatat tggaaaattt acaaaaaagg
    48361 aagataagta aatggaacta ttatcaaaat tacctttggc tgatgtacca tatacaagtt
    48421 caatgcaatt gtttttattt ctaactgcat taatgttttt accatttgta atgttcatga
    48481 tgacaagctt tgtcagaata gttataagtt tatcattttt gaaatcagca ttaggagcac
    48541 agcaagcaat tccaagtcaa attttggtag ggcttgcaat agtattgaca atatttataa
    48601 tgagaccagt attaaatgag ataaacgaaa aggcattaca accatatatg aaagaagaag
    48661 ttactatgga agaagctatg aaggaagcag aaggacctat taaagaattt ttattaaagc
    48721 aaaccagaca gacagattta gatttatttg tagagcaagc tggtttaaaa gaaaagaaat
    48781 taactcgtga aaatatacca ttatctgttg tagttccagc atttgctata agtgaactaa
    48841 aaactgcttt tcaaataggt tttttaatat atataccatt tttgataata gaccttgttg
    48901 tggcaagtgt tttgatgtct atgggtatgt ttatgttacc tccagttatg atatcattac
    48961 catttaaatt attattattt gtaatggtgg atggatggaa cttgatagta aaaacattga
    49021 tattgggatt tggataggag aaaaatagta tgagtgaatt tatgataatg agtgttctta
    49081 aaaatggcat gtttacagga gctatgattg cagctccagt gctaattgtt tctcttgtag
    49141 tggggctttt aataagtgta tttcaagcca caactcaaat ccaagagcaa actttgactt
    49201 ttgtaccaaa actaatagca attcttttag tagtagctat tggtggaagc tggatgttac
    49261 atactcttat tagctttact tcggagatat tcaatatgat gtctctcata actaaataag
    49321 taggatatat atgatttttg tatttattag aatagtagca ttctttggaa cattaaggat
    49381 actatttcca gctggtacac ctgctttatt taagtcgctc tttgcaatca ttatatcaat
    49441 cttgatttca agtactatgc aaattgaata tgcaacaaat atagacaaca ttgtattgtt
    49501 taccttatat ggtataaatg agaccataac tgggattatg cttggatata taaccaatct
    49561 atgtttttat agtatcagaa tggctggttc tatgatggac caacagatgg gattatcaat
    49621 gattaatatg tttgacccaa attcaatgac tcagacaact ttaatcaata atcttatgaa
    49681 ctggacagca cttatgatat tttttagcat ggatggtcat catgttttaa ttagaggcat
    49741 aaggtatagt tttgagttaa ttccaatagg gaaatcattc atagataata atatagatta
    49801 tataataaac atatttgtgc agtgcttttt aactggattc aaaatagcaa tacctattgt
    49861 actttgtctg cttatggcag attttatatt agggcttata tcaagaagtg tacctcaact
    49921 aaatgtaatg ataattggta tgccattaaa aatactggtt ggtattgcat tatttatcat
    49981 atcaatacct ttaattgtca atcaaataag tcatttatta agtcaaatac caaagatgta
    50041 tgagggaact tttgcactag ctcctatgtt ttttatgggt tcaacagata aaacagaaga
    50101 agctactcca aagaaaaagg gagaacaaag aaaaaaaggt aatatagcaa agagtaaaga
    50161 attacccatt gcaatgactc tacttgcatt cactttatta gtacctacat tattttcata
    50221 tgtagtgaat acacttaaat cttctcttaa ttattttttg agtctagatt tttatatgaa
    50281 cataaattat tcaagtatag agaaattagt tatagcagga ttaatggatt tttttaagat
    50341 atttttacca atagctattc cattcttagt tttaggtata gtcgcaaacc tatttcaagt
    50401 aggaatactg tttactggtg aaactttaaa acccaattta tcaaaattaa atccaattag
    50461 tggattcaaa aacatgtttt ctatgagaag tttgtcaacc ttaataaaag atacagcgat
    50521 tatatctatt ttggcttaca taggatatac attcttccaa gataattatt tagatatatt
    50581 aaagttaggt aacatatacc tgccaacttt aatgtacaca gttaaagatt tagtatattc
    50641 aatattaagt aagatttgtg tagctatgat agttatagca gttgcagatt atgtttatca
    50701 aagatacagt cataaaaagc aacttagaat gacaaaacaa gaagttaaag atgaatataa
    50761 aaactcagaa ggagacccag aaataaaagc taagataaaa caaaaacaaa gacaaatttc
    50821 gtctcaaaga accatgcaag cagtaccaag tgctactgta atagtaacca atcccaccca
    50881 cttatctata gcagtgagat atgaaaaagg gaaagaccaa gctccagtag tggtggcaaa
    50941 aggtgcagat tatttagctt ttaaaataag ggaaattgca aagggaaatg acatacctat
    51001 aatagaaaat aaacctattg ctaggttgtt atataagcaa gtagaaatag accaagaaat
    51061 tccagaggac atgtatcaag cttttgcaga gatattagta gcagtatata aaatcaaaaa
    51121 tagatacaaa gtccccaaaa ggtaggataa gtaatgaata agtttaattt aaaggaaaat
    51181 atggacgtaa tagtggcatt tggtgttgta gggattgttc ttatgatgat agtgccgtta
    51241 cctacattta tattagatat tttactggca attaacataa gtttatctgt gctaatttta
    51301 ctaatgacac tatttacaac aaatgtactt gatttatcta tatttccaac agtgttactt
    51361 gtgacaacac tatttagatt gggattaaat ctttcatcaa ctagattgat tttaacacag
    51421 ggatatgcag gtgaagttat agaggcattt ggaagttttg ttgtaggtgg aaattacgta
    51481 gtaggaataa ttatattctt aattatatta attgttcaat ttgttgttat aaccaatggt
    51541 tctggaagag tatctgaagt aacagctaga tttacgttag atgccatgcc aggtaagcag
    51601 atgagtatag atgcagattt aaatgcagga gttatagatg acaaaactgc tagaaaaaga
    51661 agaaaagagc ttcagcaaga agcagatttt tatggctcta tggatggagc aaataagttt
    51721 gtaaagggag atgccatagc aggtcttata gtaacagcaa taaacataat aggtggaatt
    51781 gtaataggag ctgtaatgct gaatatgact cttatgggtg cagcacagac atatgtaaga
    51841 cttactatag gggatggtct tgtaagccag atacctgctc tattaatatc tacatcagca
    51901 ggtataatcg taacaagagc ttctactgat gaaaactttg gtggattagt aggtaaacag
    51961 ttaacagcaa taccaaaagc agtaatgatg actggctgtg ttctaatcgt acttggtatg
    52021 atgcctggat tacctaaacc agcatttttt tcactaggta taggtgctat agcagcaggt
    52081 tactttttag gaagagaaaa gaaagatact ttagaagact tggagtttga aaaacctgat
    52141 atggtaaatc cagataaaaa tgaagtagaa gatgtaacaa acttaataaa tgtagaatca
    52201 atagaagtag aaattggata tggtttaata tctttagctg atgaatcagc aggaggagat
    52261 ttacttcaga gaatagcatc aataagaaga caatgtgcaa tagacatggg tatagtcgta
    52321 caacctataa gaataagaga taatttacag ttaaatccaa accaatacaa tataaaaata
    52381 aaagggaatg tagttggtgg gtatgagata atgcctaata tggttttatg tatggatcct
    52441 atgaatcaag gatttagtat atttggaata aagacaattg agcctacttt tggaatagag
    52501 gcactttgga tagaaagtga caaggtagaa gatgcagagc taaagggtta tacagttgta
    52561 gattcatcca caatacttat aactcactta ctagatataa taaaatcaaa tgcacacgaa
    52621 ttactgggaa gacaagaagt taagactatt atagatgcag caagagaaaa ttatagtgct
    52681 gtagtagatg aattgatacc agatttaatg acacttggtg aaattcaaaa agtacttaaa
    52741 aatctgttaa gagaaaaagt aaatataaag gatagagtta caatacttga gacacttgca
    52801 gaccagtcta gaaatacaaa agatatagag cttcttactg aatatgtaag aatagctttg
    52861 gctagaagta tttgtaataa tttagttgat gaagataagg caattgtagt ggctacattg
    52921 tctccagaaa ctgaagaatt ggtatctaat aatttacaaa ggtctgtaaa tggaacttat
    52981 ccagcagttg acccagaaaa tacaaataaa atatttgaga gtatacaaga agtaatgaac
    53041 aatgtatatt tcaatcataa tataccagta atagtagtat caccaaagat aagagctcca
    53101 tttagaaaat tagttgaaat tgtatatcct aatttgactg tattatcatt aaatgaaata
    53161 cctaacgata ttaaaatcaa agcagaaggt gtggtgagca tatatgatga cgaaaaagta
    53221 tacagctaac acaattcaag atgctatgaa tctagccaaa atggaattgg gtgacaatat
    53281 tacattaata gataaaaaag aggtaagaaa atctggaata agaggcattt tttcaaagaa
    53341 agatattgaa ttgactattg gatgggaaaa gaaagataat ttagaacaaa aagatttaaa
    53401 acgagagata gaacaactaa agtcaattat aaataatatg gggtttgata ataaaaatga
    53461 taatgatata gataaaatat gcaagaattt actaaactta gatttaaatc aagaaattgt
    53521 agaatttata aaagctgatt tacaagaaat gaagttcaat ggaattgata caagtaaaaa
    53581 tttagtagaa agtctaaaga aaaagattaa aatagaaaat caagcaataa atggtaaaat
    53641 tgctttagtt ggaccaccag gagtaggtaa aacgactaca atagcaaagt tggctgccaa
    53701 attagttttt gaggaaaata aaaaagtagg agtaataact atagatacat acaggattgg
    53761 tgctgtagaa cagttaaaga tatatactga tataatgaat attcctttta aaggggtaat
    53821 aagccctgat gagatggaat tggcacttga tgagatgaaa gattgtgatg ttgtattaat
    53881 agatacaaca ggtagaggct ataaaaactc tatgcaaata ttagaaatca aaaatcttat
    53941 agataaagct gaaactgata atatacattt agttttgaac tgtacaacaa gagaaagtga
    54001 tacaaaagca attatagatt catatagaaa tgtgaatttt aaaagcttaa taattacaaa
    54061 gttagatgaa acaataacat atggctcaat atttaacata atgaattatg cacaaaaacc
    54121 aatatcatat attacaacag gacaaaatgt tcctgatgat attataaaac ctaatgaaga
    54181 taagattata agattactat taggagttga aagtatatga tagaccaagc tcaaattttg
    54241 agaaaaatgg caatggaaaa aagaggttct gatgagatta tagtagagaa tgagaatatg
    54301 cctaagataa ttacaatagc ttctggtaaa ggcggcgttg gaaagagtaa tctcgctaca
    54361 aatttgtcta tatgcttaac caaacttgat aaaaaagttc ttatattaga tgcagatata
    54421 ggaatgtcta atatagatat aataatgggg gtaaatgtaa aagggactat aattgatgta
    54481 attaatggcg aaaaaaatat agaagatata atttcacaga ctaagtatgg tgtaaatata
    54541 atatctggag gttctgccct taatcatata gaagacttta cagaagctca aagaaataag
    54601 tttatacata gcatagaaca gattcacaat gtggatttta taataattga tacaggagct
    54661 ggtatgagca aaagcctatt gtcatttata tactgtagta ctgaattttt cttaataaca
    54721 actccagaac cgacatcatt gactgacgca tatagtttat taaaagctat aagtaatttt
    54781 ggcataaaga aaagtgcaaa tataataatc aatagggtaa ttgatttaga agaagcgaaa
    54841 tctacataca aaagaataaa aatggttgtg gacaaatttc taaaccttaa tctggaattg
    54901 tatggatata taatagatga caaaaaagta ggtgtatgtg taaaaaaaca gataccattc
    54961 attttagaat atcctacaag tattgcatca aaatgtatta tagctatagc aaagagaatg
    55021 gtaagtcagt caagagaaga tattgttgat aataaaagtt ttctaagaaa gatgtttagt
    55081 atatttaaaa gctaaggagg cgtagttaat gaatagagaa gaattaataa aagagaatat
    55141 gcctcttgta aagagtatag caagaaaatt ttttatacca gggaaaggtt ttgaatatca
    55201 agacttagta aatagtggag tcattggatt gattgatgca ataaataaat ttgatactga
    55261 aaaaggagca aagttttcta gttactctta tataaagata aaatctgcta tattagatga
    55321 aattagaaat caaagtccaa tttctaaaca taatctaact aaagtaaata agtataatag
    55381 agtggtagaa aagttgcaat ctaaattatt aagagagcca acttcatatg aaattgcaaa
    55441 agaattaaag gtttcagaaa aagaacttca tgatatcgaa agtaatatag atatgttaaa
    55501 tattgtatca ttaaactatg taatctttga agatacaaat gaaactgtac aagatgtaat
    55561 aagtgataga gaagaggaag ctccagaaaa tataatagaa gaagaagaaa agttagagat
    55621 tctatccaaa gcaattagta atttaaatga aagagaaaaa ttaatacttt cactgtacta
    55681 ttatgaagat ttaaatctaa aggagatagg gaaagtgcta ggtgtttcag aatcaagagt
    55741 ttcacaactc cacagaaaat caataagaaa cttaagaaac aagataaaag aacttaaata
    55801 ttctatatag atggtgattg ataagatgat acaaattata ttaatagtag tgtctatttt
    55861 aataatagta actatagtta taaatttaca gaaggaatca aaaaataaag ataacagata
    55921 ctttgataaa atatttgagc aagaatatga agcaaatgat agattaataa ttgcagaaaa
    55981 aagaagattc tttttagaca aagtacttgc agaaaaaaga attaatagtc atataaaagt
    56041 ttatgaaaat tataacctaa taaaggctaa tgaagaaaga aaggaaaaca tatttataga
    56101 atcaaaaaag gaagtaagac aagaaaatga gttatctctt aaagtgaaac atcttataag
    56161 ttcaggttat gatgatgtgg aaatatgtaa gatgctagat attggaaagg gggaactgtt
    56221 attaataagg agttgttaca aaatataagg atattattat gtgataaaaa agtattctta
    56281 ggaataggta ttggtatatt aatatcaact ttatgtataa tgctttttag taataatgat
    56341 atgagtaagg cagagataga aaaaaaggcc agagcgttag gcatgaaata tacaagtgag
    56401 atgaaagttt tagaatagat gatactgttt agacatttac aaaaaaggag gtcataatgt
    56461 gataagagga ttatatacag cagtttctgc tatgataact aatcaacaaa agcaaaatgt
    56521 tgttgtcaat aacctagcta atatggatac aaatggatat aaaagtaaac aacttttgac
    56581 taaaagtttt gatgaattaa agttggaggg ttacaataac tacgcaaatg gaactaaaca
    56641 aaagcagatt ataggcgata taagtccagg tatttctatg gatgaaacta tcacaaattt
    56701 taatcaagga cctataaaaa ctactgataa taaaatggat gtagctattc aaggtaaggg
    56761 attttttcta gttagtgatg cagctggaaa tcaattttac actagaaatg ggaacttcag
    56821 aacagacaat caaggtgacc ttataacaag tgaagggtat tatgtacttg ggacgaatac
    56881 tgctactggt gctgtaggtc atataaatgt aggaaatcaa aaatttgaag tggcaaaaga
    56941 taatacaata tcactagacg gaaatgctat gtataaattt aatattgtag attttaataa
    57001 ctacaataac ttaaaaaaag aaggagataa cttatattct ggaggaggag ctatgaaagt
    57061 aaataatgca cttacaatac aaagtgcgat agagtcctct aatgtagata tggtatctga
    57121 aattaataat atgatgacaa tatcaagaga atatgaggca aatcaaaaga taattcaggc
    57181 tatggattct aaattagcaa aaatagcaag tgagattggt tcagtaagat aggtaatagg
    57241 aggtgaattt ttatgtacac aatgttttat actagtaaaa cagctttatc agcaaatcaa
    57301 agtaaactag atataatatc taacaatata gcaaattctg attcaacagg atataaaaaa
    57361 ataaatatgg aatattctga tttagtggat gaagtactaa atagaccatc ataccctaca
    57421 aatggtaaag atatatcgac tggaacagga gctaaggcaa cagctcccat gagaaattat
    57481 gaacaaggtg cattggctcc tacagatagt aagagtaatt tggcgataga tggagaagga
    57541 ttctttagag tgataagaaa agatggtaca tatgcatata caagaaatgg tggatttaat
    57601 gtagatgctt taggtaagat tgtagatgat aatggaaata tattagatgt ccaatttgat
    57661 gcaggatata actataataa tacaaatata gatagtacaa acctgacagt ttcaagaaat
    57721 ggagagctat tcgtagataa taaaaaaata ggaaaaatta acttatatca acctatagga
    57781 actcaaaatt ttatatctga aggagatagt ttatttgtcg caactgatgc agcacagatt
    57841 aaacaagttg agaaagtcga tatagttcaa ggctatagag agaggtcaaa tgtttcttta
    57901 caagaagaat ttgttgactt aatagccact caaagagcat ttcaaatgaa ctcaaaggga
    57961 ataaagacag cagatgaaat gtggcaaata gcgaataatt taagagctaa ataattatgt
    58021 aaggagagga atattcatga atgatatgaa agagtacgat tttggcaaac ctcagagtta
    58081 ttcaagagaa aatttaactt gtttaaattt tttattagct gaattttgta aaaaatataa
    58141 aaactatata atttatgaac ttaagtgtaa ttctagtatg gttgttgata gtatagacca
    58201 agtaaattat cagacttttt tagatagagt aacttcttca tgcgtagtag tacaaaatgc
    58261 aatggaacct gttatgaaaa acttttcttt tagaatagat agaagtgtag ctgatatgtg
    58321 gattgatata acttctggag gaactggagt tgtaaaggat aatgatagag agcttacaga
    58381 acttgataaa aaagtgcttt tacaccttat ggatgattta gtaagaaata tgcacttatt
    58441 tgagggtttt gaaaatatac aagtattgga tacacataca catattaatt tgccacaatt
    58501 atgttctcca actgcaccag tatgcgttgt agatttaaaa gtgctaaatg ataatgagtg
    58561 tattggaagt gtttctcttt gttttccata caatggttta gaggctctgt tagaaagtat
    58621 atctgttata gaattttttg ataatgatgt aggagatgat tcagaggaat ttacccaaaa
    58681 aatctataat agtgtatcta atatagaatt atcagttatt gcagagatag gaaaagtatc
    58741 aattaatgtt gaggatttac ttaaactaga agttggagat gtaatagtaa caaataaaaa
    58801 aataaatgat tatatagata tatttgtaga aaattcaaaa tcatacacag caacaccagg
    58861 atttatatca agtaaaaaag gtgtaaaaat aaatgatgct gttggaaaag aggtgtagtt
    58921 atggacaata gtaatcttat ttcagatgaa gaagcaaaga tgttattaaa tgataaagtt
    58981 gaaagtgaag ttgatggaga tgatgagtta gccttagatg tctctgaagt taatcgaaat
    59041 aatatacaaa ggatacttga ccttaagtta gaattatctg tagttatagg aagaactaag
    59101 atgactctaa gagatatttt aaatttacat aaaggttctc ttattgaact ggatacttta
    59161 gcagaccaag atgtggaaat actaatagat aataaggttt tggcttatgg aaaagtagtg
    59221 gtggtagatt taaattttgg tgtaaagata acaagtatag taagtgaaga agacatggta
    59281 aaatctcttg tttagagata acatcaatta atacttaagg catgaggtgg tacttatttt
    59341 aaacttaaat gatataaaaa aagatatact aaaactcaat aaaaaagact catgttctct
    59401 atataatgaa tctattaata atataaataa taattgtata tcaactggat taaaattttt
    59461 aaaacaagca agagatttaa acccagatga tgttgatata ttaaatctca caggtcttgt
    59521 aaacttacta aaatgtaatt ttgatgatgc tgtagaaagt ttctataaga gttcactttg
    59581 tgaaaaaact gctctgtgtg aaaagtatat aaacatgctt acatctgagg agtttttaat
    59641 tttctttgaa aagtacaatc aacttataag gttaataaat aaaggaatgt ataaagaagc
    59701 tatacaaggg tttaaactca taactgacca atactgtgat ttaatagaac cttatgagtt
    59761 gcttgcctta ctgtatgaca aggaagaaga atatataaaa tttgatgaat gtttagaagt
    59821 attgaagatt attgataagg aaaattattt attaaatcaa gaaaataaca cattagatat
    59881 gtataatagt gctaatatac aaactaaaag taatataaaa gtagatgatt ataagaatga
    59941 gttcttacat aaaagtagta gtaaccataa aattaatgat tataatgatg taactaaaga
    60001 aaagagttca agcaaaaacc agaaaagttc agattctaat aagaaaaaaa gtattaaaaa
    60061 aaataagtac ctatatatag ccataatatt aggaatatta ttagtaggac aaagtatata
    60121 taattcttat aagatgaata atttaactga taaaatatct aaaaataatg aaactaaaaa
    60181 tgaagagtca atagattcta acttgactaa gaaagaaaat aatatagaag aaaatgaaga
    60241 tatgagtaag gcttctaata taaataagag taataaaaac attaataaag aggatgatgt
    60301 aaaatctaaa aaaaatactg tagaaaatga agatgataaa gattctgact tatttacaga
    60361 ggatgaattg atgtctaagg cgaatacttt aaaatcagaa aagaaaacta aatcttctat
    60421 acaactatat aagaaagttg cagatatagg tgaaaataaa gggaatacat ctgaagcaac
    60481 ttatcaagtt gctattctca gtgaaaagtt aaaagactat aaaactgctg aagaatatta
    60541 taaaatgtat gtagaaaatt actcagaaaa agatgcttat tttgatgaat cttattataa
    60601 tttaggtatg atgtactata acaatggtga tttaaaaaat tctaaattga cattaaagaa
    60661 gttggttaat aaggtaccaa atagtatgta taataattca aaagtaaaag aaattttaaa
    60721 agaagaatag ttaaattaga taagaaaaat aaattatttt attttaaaat aatatgatta
    60781 taatatattg acataccatt ttaaaaaatt taaaatatta attataaaat gaggagggat
    60841 aaaaaatgga atttgaaaaa gggagtattt caattcatac agaaaatatt tttcctataa
    60901 ttaaaaaatg gttatactct gataaagaca tatttataag agagcttata agtaatggat
    60961 gtgatgcagt aagtaaacat aaaagacttg tatcactagg agaaatatca gaaaataagt
    61021 catcagatta taaaattaca gtatctgtaa ataaaggaga aggtacactt aaatttattg
    61081 acaatggaat tggtatgact gaagaagaga taaaaaaata cataaatcaa gttgcttttt
    61141 caggtgctga agatttcttt aataaatata aggataaaat ggaagagtca aatgatataa
    61201 taggtcattt tggattagga ttttattctg catttatggt gtctaaaaag gtacaaatag
    61261 atacactttc atatacagaa ggagcgactc ctgtaagatg gatatctgaa ggtggtacag
    61321 aatacgaaat atctgaatca gatgctagaa atgatagagg aactactata acactattta
    61381 ttgatgatga tagtaaagaa tttttagatg aatttactgt aagaggaata ataaataaat
    61441 actgttcttt cttaccagta gaaatatatt tagaagatgt tgaaagatta gaaagagaag
    61501 ctaaagaagc agaagaaaaa gctaaaaaac aaaaggaaga tggaaaagaa gagattgtag
    61561 atgcaaaagt aattgagcct ttaaacgaca ctaatcctct atggttaaaa tctccaaaag
    61621 actgtactga tgaggagtat aaagagtttt atagaaaggt attcaatgta tttgatgaac
    61681 ctttattttg gatacattta aatgtagatt atcctttcaa tttaaagggt atactttact
    61741 tccctaaatt aaaaaatgag tttgaactga ctgaaggaaa agtaaaatta tacaacaatc
    61801 aagtgtttgt ggctgacaat ataaaagaag ttataccaga atttttactt ttattaaaag
    61861 gagttataga ctgcccagac ttaccattaa atgtatcaag aagtttctta caaaatgaca
    61921 gggatgtaag caaaatttct aaacatataa ttaaaaaagt agctgataag ttaaaatctc
    61981 tttgtaaaaa tgaaagagaa gaatacaata agttttggga tgatatacaa atatttatta
    62041 aatatggttg cttaaaagat gaaagtttct atgagaaggt aaaagaatgt atattattca
    62101 aaactattga tgatgagtat ataacattac aagattattt agaaaagtgt aaggacaaac
    62161 atgaaaataa ggtattttat gtaagtgata aagaacagca atctcaatac attaaactat
    62221 ttaaagaata cgacttaagt gctgttgttt taaactcatc aatagatact cattttattt
    62281 catttatgga atataaagag aatggagtta agtttaatag aatagatgca gacctttctg
    62341 atgtattaaa agataaaaat gaaaataaag atagtgaaga aaacaaagaa gagatagcta
    62401 agatagaagg tctgtttaaa gaagctgttg gagaaagagt gaagaattat tctgtagaag
    62461 gattgaaaaa tgaagacact ccagctatgg tgttagtatc agaacaatct attagaatgg
    62521 cagaaatgca gtcaagattt gctggaatgg atttaggaat gaattttgaa gaagaaaaaa
    62581 ctcttgtaat aaatgagaac agtccaataa tcaaaaaatt ggtttctctt aaagatgatg
    62641 aggaaaagaa agataagatt acgcttattt gtaaccagat agcagattta gctttacttt
    62701 ctaataaaga attaaagcca gatgagttag attcatttgt acaaagaagt aataagctta
    62761 tgagtctttt gatagaatta taagattgaa tttgaataca ttgaagcaaa tttataaaaa
    62821 gtattcaata tcagtgataa gaaagaagtg tctcaaaatg aacttttcag ttcatgaggc
    62881 gcttttttta tgtgaaatta aatttatttt aatcatttca acaatgaaaa atatatttat
    62941 ctctattttg agacagaccg ttctttattt ttttatcttt ggttaatttt taaatattta
    63001 agtaggttct aataaaaaac tctatttagt taaatatagt taacttgata tataataaga
    63061 taatacatat aattaagtaa aagattgttt tttagtttat gtttaaatac ataattacac
    63121 tttgttaaaa acataaaatt attactaaag tagaaatagg aggttttagc atgaatttta
    63181 attataattt gccagtaaat atcttatttg ggagcggcag aattaatgat gtgggaaaag
    63241 aagtatctaa atatggcaaa aaagtattga tagtaacagg taaaaatagt acaaagaaaa
    63301 ctggattact tgataaaaca atagatttac taaaagactc taaaatagaa tatgaagttt
    63361 ttgatagagt agaacaaaat cctcttataa ctactatata ttcaggagta gaaattataa
    63421 aatcaactgg atgtgattgt gttttaggtc ttggtggtgg aagcattatg gatgctgcca
    63481 agagtatagc tttttcttat aaaaacccag gagatttaaa tgattatata tttggaatta
    63541 gacaaggtga agaagcttta cctataatct tagttccaac aacatcaggt acaggtagtg
    63601 aaggaaattg ttttgcagta cttacaaatt cagaaactaa agataaaaaa tctataaaga
    63661 agaatagtat gtatgcaaaa gcatcaataa ttgacccaga acttatggtt acaatgccaa
    63721 aacatataat tgcatcagtt ggatttgatg cacttgccca taatatggaa gcatatcttt
    63781 ctaatggaag aaaccctctt gcagatgtac aagctattta tgggattgaa cttatatcag
    63841 aaaacctaat aaaggtatat aatgatgtta atgatttaga agcatgggaa aaaataacac
    63901 ttgcaagtac tattggagga atgacgattg gtacagcggg tacagccttg ccacatggaa
    63961 tggagcatcc tgtaagtggt cttagagatg taatgcatgg aaaaggactt gcagctttga
    64021 ctcctactat tatagaaagt tcatgggata gtgatattga aagatttggt aatatttcaa
    64081 aggtattagg aggaacttgt gcagaagatt gttcagatgc aattagaaat ttccttaaaa
    64141 aaatagattt agatataaag ctaagtgatt taggtattga aaaatcagat atagattggt
    64201 taactgataa ttgtatgaaa atatcagttg caaatattaa gagacatcca aagtatttta
    64261 ataaggaaca aataaaggaa atgtaccata agtctttata atttgacttt acatatttag
    64321 ttttatataa aaattataaa ttaataata
//
LOCUS       DAEHWM010000010        60758 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.010, whole genome shotgun sequence.
ACCESSION   DAEHWM010000010 DAEHWM010000000
VERSION     DAEHWM010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 60758)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 60758)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..60758
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.010"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(880..1389)
                     /locus_tag="KNP36_000687"
     CDS             complement(880..1389)
                     /locus_tag="KNP36_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CarD family transcriptional regulator"
                     /protein_id="HBF0872578.1"
                     /translation="MVMFLFKIDDYIMYGMTGVCKVMDITNERFTNGIKKEYYVLSPI
                     YSNNTVIKIPVDNEKVPMRKLLSKINVLSLINDIPNMDTSWIDNEKLRSEQFKKILRG
                     GKCEELIKLVRSIDNNREYVKSIGKKTHQADDNIMKEAERLLNEEFATILDISPNEVS
                     SYISSHIPQ"
     gene            complement(1600..3009)
                     /locus_tag="KNP36_000688"
     CDS             complement(1600..3009)
                     /locus_tag="KNP36_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VWA domain-containing protein"
                     /protein_id="HBF0872579.1"
                     /translation="MENYFDKQAKELYNKASEIINTHSMLKANRANEKFDIDIPQDFK
                     YEFFSLVDKVNLSLMEEEDNFYGYFLFQMSREIRFDISSPTGVNFKGAKYIIYFNPII
                     FLTLDIKQMETTIKHEIHHILSMHLMRAKELKGKYSTLAINMAMDIVVNKFLNNLPPY
                     ATTLEWVNLKYSLKLEPYEPFEYYVEKIQTELDLMEVDEDGEEDDSDKYGDIEIDYSP
                     ERTHDIWDESNEIDENTLREFTEKFINSSQKGKVPAYLESMISSLKNSKGELPWNLYL
                     NRIMGTVENNKKKTITRRNRRQPNRLDLRGELRSHKSEIAVALDVSGSISDEEFKQAI
                     KEVLSIVKNYNHEITIIECDNEIRRVYKVRTEKDIKDRIRIGGGTRFSPVFEYANNKK
                     INLLVYFTDGKGENKLQVIPRGYKILWVISGRGDKISLKEPYGAVKKLTKVKTNDEIL
                     EINDVRNDGYSMNSQAPIL"
     gene            complement(3013..4143)
                     /locus_tag="KNP36_000689"
     CDS             complement(3013..4143)
                     /locus_tag="KNP36_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872580.1"
                     /translation="MNFIDTLKSVDLILSTGEVPLIVGESGIGKTALANKLAKENDWS
                     LIVIDGNLLKEGEIGGLPTIESYVGVNSNGYKTEKKTTVYAVHNKLREIDEEISKSKT
                     VLLFIDEINRCEHTVQQELMNLILNREINGYKLHDDVKILAAMNPSSKYGSDFDYQVV
                     DMDAAQENRFVWLNMESDHTQWIKWAIDEGIERKVIEFISTFPEYLHKINEDDVRATP
                     RSYERVSKIYKVYKEKNNSIPRAVFLNVVKGNVGKVIAEEFISFIESNSEPLISYEDV
                     FLGESIDESIVERVKNESHTRLYLSAMNILKDLELNIKNDKYESNHYINRFIEFLKMY
                     PVDLMIGIMKDIRNSYIEVYKKAIENEEFVKSYFESYSLIRG"
     gene            complement(4155..4958)
                     /locus_tag="KNP36_000690"
     CDS             complement(4155..4958)
                     /locus_tag="KNP36_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872581.1"
                     /translation="MEKLRVIEMIKNNPNIIATIDNPTDEMKLLAIKENGLVLEYINN
                     PTREMQELAIDNNIRAIKFIDNPTEDMMIKAVNEGWSILDYIKNPTDKVIEMAINQAG
                     WAIKYAKNPSEELQLLAVRKNYDSIKFIKQPYESVQEEAVRISYDALRYIDSPSYNAE
                     LIAIKNNEAAISFITDLDKNKMLEFLKVNILVIKYILKKVSKDELESALKEVLSKEDV
                     EEKYIRDFLNCSVIDRNSESIPIDKIMFIYKYGSKTAKKIAVDEKLKIM"
     gene            complement(5340..6221)
                     /locus_tag="KNP36_000691"
     CDS             complement(5340..6221)
                     /locus_tag="KNP36_000691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline iminopeptidase-family hydrolase"
                     /protein_id="HBF0872582.1"
                     /translation="MKITEGYMPFKGFKTYYRIVGENTEGKKPLVLLHGGPGSTHNYF
                     EVLDKIAESGRQVIMYDQIGCGNSFVEGHPELFNADTWIEELIELRKHLGLDEIHLLG
                     QSWGGMQAIWYAIEYKPKGIKSYILSSTLSSAKLWEKEQKRRISYMSEVDQKALLDAV
                     NTGDYSSKEYNDALERFMEMYCAGEVTEDSPECLRRPKKSGSEAYIVGWGQNEFSPTG
                     TLSGYEFTDRLHEIKEPCLVTSGAIDLCSPYIAKTMYDRIPNSKWELFEYSRHMPFVE
                     ENEKYIKVLTEWLNAND"
     gene            6677..7651
                     /locus_tag="KNP36_000692"
     CDS             6677..7651
                     /locus_tag="KNP36_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872583.1"
                     /translation="MNNINSLKVIKLSLGCSLAIFIAWLLKLEYSMVAGVIVLLTVKD
                     TKRETLKGSIGKIYGFLLCTIFSYLCFNILGYNLTSFSIFIFIIIPLCFLLNIQDVIA
                     MCVVIASHYYLQGETSIKWILNEAGIFAVGTGIGVLINMYIPTNIHKIHEVQKKLQEE
                     VSIVLIDIADIIVNPKKENGYSRDLYTLNSLIDSSISETYDNINNTLLSDTRFFLEHM
                     DIIKSQRDILENLYSYVSQLNSTPPQAHILSAFIHKIGYTEFEAETGNLLLEELKRLM
                     LSMKNQPLPVDRTEFENRAILFLCLTELKQFLVNRKHAQMLRDNNFYK"
     gene            complement(7767..8828)
                     /locus_tag="KNP36_000693"
     CDS             complement(7767..8828)
                     /locus_tag="KNP36_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBF0872584.1"
                     /translation="MKKIRKLATKLLITTIVLISGMSMTVYGMTAKEVTAKTPKSYVT
                     GTNSVYGPKLSQAQLNSVAQATADFMNKKITKNMTTDAKILVAYNHIKNNTTYVDWNA
                     VEGANTAYTLVTKKGACSGMARSMKALCDAMGIESYYVHSTSNDHQWNLIRFGDGRLY
                     HVDIDANKSAGKDIIYKSLSHPLPFDKTAYPKVGAIVQTVKPEQTQKPAPPGKHTMLP
                     HQEGAKAVGNFGKKGEDINEKHVMYEGVRCSVVNSSVNTITFTGSESNLDPSNLTIAV
                     IGFMNTPYGMFALAPEGKPVEYPFKYDKPFSLDFSGKNRSGAELAKYCKKNDVTIKIE
                     ITDEKANIGLGQIMYVRYE"
     gene            complement(9440..10291)
                     /locus_tag="KNP36_000694"
     CDS             complement(9440..10291)
                     /locus_tag="KNP36_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0872585.1"
                     /translation="MSCILKLKQIYEDLTEVDKKIADYILNNTEAISKLSVSELASNS
                     KTSTASIVRFSRKMGYSGFGDLKIEIAKDLMGKENEYTYVDENYDCNIDSVINKITNK
                     NIETINQTRLLNEKDIIKEAVEQIIKAKNVYIFGVGGSALVALDLQMKLLRINKQAFT
                     SLDSHTQLMVSSNVDKEDIAIAISYSGESKEVIKSIENAKLKGCKVICITKYSDNHLS
                     KISDLKLVVPNIEKRLREGAISSRIAMLTLIDIIYISIIQENLNEAEQKLQETKRILD
                     YLNINNA"
     gene            complement(10308..11228)
                     /locus_tag="KNP36_000695"
     CDS             complement(10308..11228)
                     /locus_tag="KNP36_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA reductase"
                     /protein_id="HBF0872586.1"
                     /translation="MYFLGVDGGGTKTTFTLVDEELNIVGTITKGTCHYNQIGFDNLT
                     KLLITGLEEVCKDAKINVEEITYAFVGLAGYGKIKEVLYALEVATKNAYSHINYTLGN
                     DVEIALAGSLNGEKGINIIAGTGSIAQALDKDGNLHRCGGWGYVLGDEGSAYYIGMAT
                     LKMFTMQSDGRCSKTKLYDLIKRHLNIENDYDIIKYVNDEIKGDRIEIAKFATICLKA
                     VIEGDNTASKIFDDAAYELSRLIIGLEHHFEQGTKIKVSYSGGVFKSGDLILEPLKKY
                     LNKTRFGIVRPVLTPDLGACLLAKKKYYSK"
     gene            complement(11338..12252)
                     /gene="murQ"
                     /locus_tag="KNP36_000696"
     CDS             complement(11338..12252)
                     /gene="murQ"
                     /locus_tag="KNP36_000696"
                     /EC_number="4.2.1.126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramic acid 6-phosphate etherase"
                     /protein_id="HBF0872587.1"
                     /translation="MLIKTLENLVTEGRNKNTLQIDKEDTLGIIELINNEDKTVAYAV
                     EEQKESIAKAVNIIVDRMKQGGRLFYIGAGTSGRIGILDATECPPTYGVDFELVQAII
                     AGGNQAIFKAIEGAEDDKELGKQDIIDRGVTSKDVICGIAASGRTPYVIGAMEYAKEL
                     GCAVLSITMNPNSEMSKKADLPINIIVGAEVIMGSTRMKSGTAQKMVCNMLTTASMVK
                     MGKVYSNLMVDVKTSNEKLVERAKRIIMIATNVKYDVAEKFLEEADNSVKLAIFMIKS
                     GLDKDSAKSILDRQEGYISEALKSIEKL"
     gene            complement(12351..13448)
                     /locus_tag="KNP36_000697"
     CDS             complement(12351..13448)
                     /locus_tag="KNP36_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF871 domain-containing protein"
                     /protein_id="HBF0872588.1"
                     /translation="MGRLGISIYPEKTTSKEIYDYIDKAAENGFTRIFSCLLSVKDTK
                     ENIIKKFKSINEYAKFKGFEVILDVNPRVFGELEISYKDLNFFKKTKADGIRLDMGFT
                     GSEEALMTFNPQNLKIEINMSNNTNYIDTIMDYQPNKENLIGCHNFYPHRYSGLNLEH
                     FIKCTERFNKYGLRTAVFVTSQNETTFGPWPVTDGLPTIEMHRNLPIDIQVKHIIAMN
                     NINDIIISNCYPTYEELKVLGSMRKDMVTFDVAIEENIREVEKKILFEEIHFNRGDIS
                     DSLIRSTQSRVKYKGYKFELFNTPKIIKRGDIVIESSEYGHYAGELQIALTDMKNSGK
                     SNVVGYIRKEELFILDYIKPWQKFNFKPSTK"
     gene            complement(13681..15027)
                     /locus_tag="KNP36_000698"
     CDS             complement(13681..15027)
                     /locus_tag="KNP36_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872589.1"
                     /translation="MLDKFTEFLDTKLSTSMARLAEQRHLRAVRDGIVASLPLIIVGS
                     FFLILAFPPLPDSWGVTQYLKENAVTILLPYRMTFFIISVYSTFGIGYSLAKSYKLDG
                     LTGGLLATATFLLTIVPTAIEGLTPDLLKIVEKSPELLAWYNSIPQGWQMPMANLGGG
                     SMFVAIVTSIIGVEIYRFTDKSKFKITMPEAVPASVTRSFEALTPAALIIILMAIVTY
                     FLGFDWHGFIAKLVTPLVSATDTLPSVIILIFLITFFWSFGIHGVSIIGSLARPLWIQ
                     LLDANTASYAAGQAVPGIAAEPFFQWFIWIGGSGATIGLALLLAFRAKSAYGKSLGKA
                     TVIPAIFNINEPIIFGAPIVLNPILIIPFVVAPIVMATVSWFAMSANLVSRVVVTAPW
                     TLPGPVGAYLATGGDWRASVLNLLCIAISIIIYYPFVKMYDKRLLHEEKVEEQEAY"
     gene            complement(15116..15424)
                     /locus_tag="KNP36_000699"
     CDS             complement(15116..15424)
                     /locus_tag="KNP36_000699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872590.1"
                     /translation="MRVLFVCSSGMSSAIAVNALQKEGAKNGIDIDVLAVGTQEFEDE
                     VKNGWDIAMVAPQVRHRFDYLKAFADEVSVPCALIQAQAYSPLGGPKLLKQVQELLSK
                     "
     gene            complement(15687..16085)
                     /locus_tag="KNP36_000700"
     CDS             complement(15687..16085)
                     /locus_tag="KNP36_000700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872591.1"
                     /translation="MSNNKKKKRKKNNNYKNAKSTKSNKNTKKQMEKNQRTDYNIPTI
                     SFKSGLILIVSSLVSTVVFPLLLSIFGIDNRFGVVIGNSLITSFAVAYTRYFVETKRG
                     FSLGFFRLYILFALSFAIIGYFWIYKGIHI"
     gene            complement(16087..17247)
                     /locus_tag="KNP36_000701"
     CDS             complement(16087..17247)
                     /locus_tag="KNP36_000701"
                     /EC_number="2.7.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anhydro-N-acetylmuramic acid kinase"
                     /protein_id="HBF0872592.1"
                     /translation="MITMYSVGLMSGTSLDGVDAVLAEISGNGRNTKVKQIEFITLEI
                     PKDIKDEIRKCCIEEESSVDLICSLNFKLGYLFSKAVKSVCHKANFHIANLDFIASHG
                     QTIFHIPRSYNNFVSSTLQIGEPAVIAYETNTKVISNFRVMDIAAGGEGAPLVPYSEF
                     LLYSDNNKNLALQNIGGIGNITIIPKSCNIDDVFAFDTGPGNMIIDGVCQRLFNRKYD
                     KNGYFASKGKINEEMLKDLMSHKYLSQAPPKSTGREVFGQVYLDNMLNKYKHVDKYDL
                     IATVTMFTAKAIYYNYKNFILPKVNVDTLLIGGGGAHNLTLIGYIKELLLEVEVLTQD
                     EYGYSSDAKEALAFVILGNETLNNSFSNVISATGAKNKVILGNITPKPFGGK"
     gene            complement(17678..18697)
                     /locus_tag="KNP36_000702"
     CDS             complement(17678..18697)
                     /locus_tag="KNP36_000702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872593.1"
                     /translation="MLVKYLKGRSKYIALPLVVVSIINIYLFAIDIFKNKYSELIYLD
                     FLVLFIIMVFFVIDYINFRNSYTNLYNCIENSGEIDSYLVDGQSFEENLIKDIIENLK
                     IKNNSDIETYKQSLKELDEYIAKWVHEIKIPISSLSIITDRLSSIEDSLDIKNQVAKI
                     NFLVNSILYSSRSNTMFEDVFINKFNLEKLIKMSIKNNSFLLIKNNVEVSLNELENDV
                     YTDSKCMSYVLDQIINNAIKYSKEVGKIEFNSKKLENGVVLSIKDFGIGINEEDISRV
                     FDKGFTGKNGRNQLYKSTGMGMYFVKKMIDSLGHEIEVCSENGSYTIFNIYFYDISDY
                     LSLDS"
     gene            complement(18691..19371)
                     /locus_tag="KNP36_000703"
     CDS             complement(18691..19371)
                     /locus_tag="KNP36_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898117.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872594.1"
                     /translation="MYRILLVEDDIDLSKEIALALEKWGFKVELIDDFEVVLDEFIDK
                     KPDVVLLDVNLPLYNGFYWCEKIRAISNVPLIFLSSRDSDMDLIMGINNGADDYITKP
                     FSIEILVTKINGIIRRVYNYSDSNSILYCEDLMFDVGKGIIKHKYKDKSIELTKNEIK
                     ILTLLLKNKNRVVSRESLMMTLWDNDEFVTDNALTVNMNRLRSKVKELGFDDFIKTKK
                     GVGYIIQC"
     gene            complement(19523..21430)
                     /locus_tag="KNP36_000704"
     CDS             complement(19523..21430)
                     /locus_tag="KNP36_000704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0872595.1"
                     /translation="MSILGIAYNNFKSNIRTYLAFFISMVFSVVVLTNFELLRYGDAI
                     NVLQDENKKFTLSVLVAVIMILSVFLFFFIWYATNIFFKNRSKEIGILSFMGLDLYTI
                     GKIYFVENMLIGISSCITGIIIGIITSRFFQVVIIKLSGFNIKVSNGLSIEAILYATL
                     IFISIFIIMAVKGFITICRSSVINLINISKKQEKIPKVGIGIYILAIVSIIVIGYGYY
                     LSTNIRTGDITSVLPVIGIIIVGTYGLFKSVMPVIFDIIIKNKKILFNGNNIIAINNI
                     NYRLNKNYKTYAIIAIIITTTISTLGASVAMKRIHKNAQEQRNVYTISIVSMDKDEVN
                     KKQIENIIKDTNKIKYSVNPELTILKKTDIKEAYDTTDTIMKYSDFCNTLKVNGNDKE
                     LKEYGERLVSGNNVIELKSPQTIASIATKEAKIKLDGQLYNISRGEVKVPVLGTGLNQ
                     SIIVVNDDTYFKLRDKGQQVYFYGAKVFQEENSQVMFNNIEKNLSLKNGYIQNGYKAQ
                     GESQWMKFAYVVLVFLFLVFAIVAGSIIYMKIYSDAYEDKEKYKILLKIGTTEKDINR
                     AILKEVAMFYTLPMLSATISSYFALRLAGDLLMTDLFGIYILSLVICLIIFIIYGAVS
                     VNKFKSVVYKN"
     gene            complement(21431..22183)
                     /locus_tag="KNP36_000705"
     CDS             complement(21431..22183)
                     /locus_tag="KNP36_000705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872596.1"
                     /translation="MKEILKIKNISKDYGIKGFKTNVLKNISLTVNEGDFISIMGPSG
                     AGKTTLLNLMSTLDKQTSGEIILDGINISKVKNNELSKLRREKIGFIFQDYNLLDNMK
                     LMDNIALPLALGKKKSKEIEAKVFSIAKKFGLENHLDKYPYQLSGGQKQRGAAARSLI
                     TNPTVIFADEPTGALDSKSAYELLESLEKINRENNATIIMITHDPLTASYSNEVYMIN
                     DGNIKCKLNKGNSRKEFYGKIMDMLASMGGEM"
     gene            complement(22499..23653)
                     /locus_tag="KNP36_000706"
     CDS             complement(22499..23653)
                     /locus_tag="KNP36_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0872597.1"
                     /translation="MINKAIKFKFIIFYFFSYIIFAFASTKFTPFLSKLGYSAFERGI
                     ILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGIASVIMFSTESATFIIYLLL
                     VALSGGLLNTCCSLYDTWIIGCGDNINNYLSFIKTFGSIGWAIGSMVASYLILRFSYF
                     GLSVAIGLIVVLLIINILLLPDIEKINKKINVTNKDIIELLKDKKYILLVCILFLLYS
                     MVVANNCTVIDKMIALNATNSQISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSA
                     IMITVQFLLFALTNDSNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSSSQLIAL
                     SIFMGGSSLIIPTVAGFLSINIGYNYTLMVLSLFGCLAYCLIVLLNYLQE"
     gene            complement(23656..24123)
                     /locus_tag="KNP36_000707"
     CDS             complement(23656..24123)
                     /locus_tag="KNP36_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0872598.1"
                     /translation="MFFKRKKEAITINSYIDGKIINLGEIPDKVFSTKVMGDGFAMIA
                     KDNILKSPTKGVISFIAQTNHAIGIKLQNDVQILIHIGLDSATTKKENFKLEVKQGQE
                     VNMGEKLVEIDNKLLENTLYIPLVIVENPNTVKYHLSNLNQEGNSGIKVINFD"
     gene            complement(24137..24625)
                     /locus_tag="KNP36_000708"
     CDS             complement(24137..24625)
                     /locus_tag="KNP36_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872599.1"
                     /translation="MITNKIKNITAVLKDENIFLSVVMVCFLILPVLYIVYLELTSLF
                     TNISFSQLLNNDVNASLNLISNFSAVYSAYVIYNIKKNKEIKENMIAFYLVLLGQIFQ
                     IYTITIVIMFTYIYKFVGIKQIISSIKELQWGKSYKALFSSIAVCLISLFVMIIRIKL
                     IM"
     gene            complement(24639..25970)
                     /locus_tag="KNP36_000709"
     CDS             complement(24639..25970)
                     /locus_tag="KNP36_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBF0872600.1"
                     /translation="MERKRQRILIAGGGSTYTAGIVTMLIESVAKFPIESIKLYDNND
                     ERQRKVAEACAIIVREKNPEIKFSYTTNPEEAFTDIDFVMAQIRVGLYALREQDEKIP
                     LKYGVVGQETCGAGGIAYGLRTIGPIIEMIDYMEKYSPNAWMLNYSNPAAIVAEACRV
                     LRPNSRIINICDMPVCLEEIFARVLGLNSRKDFDVRYYGLNHFGWWTSIKDKEGNDLM
                     PKLQEYCAKKGYEEFTPQGQHKESSWLETMRAAKDLLEIEPTTLPNTYLKYYLMADET
                     VEHANPNYTRANEIMDRREKDTFEECERIIKNGTARDTWFDASEHSQFIVELACALAF
                     NTQERFLLIVPNNGAIENFADDAMVEIPCLVGKDMVEPMSIGKIPTFQKGLMEQQVAS
                     EKLAVEAWIEKSYQKLWQSFTMSKTVPSAKVAKEILDEMIVANKDFWPTFK"
     gene            complement(25984..27549)
                     /locus_tag="KNP36_000710"
     CDS             complement(25984..27549)
                     /locus_tag="KNP36_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003233606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0872601.1"
                     /translation="MMKKIQRFGGAMFTPTLLFAFAGIMVGFSIVFQNQSIMGSLATP
                     ENIWYQFWGVISSGAWMVFNQLPLLFAISLPIALAKKQQARACMEALATYLTFNYFVG
                     SMLSFWGKSFGVDFAAEISAGSGLVSIAGIKTLDTGMVGALLISGIVIYIHNRFYDKE
                     LPDFIGLFRGSSLVVAICFFVMIPVALLTCFIWPHIQNVIRHLQTFFINSGNIGVWCY
                     AFLQKILIPTGLHHFVYAPICYDSVVVPGGTSVYWATHIQDFQTSAKTLKEMYPIGFS
                     LSGLSKVFGSLGVFGAFYVTAKPEKKKKVLGLMIPATLTAVLTGITEPLEFTFLFVAP
                     LLFLVHAFLDACLQTISFALGVVGDFGGGIINWVVLNWLPLGMYHWKVYVVQVVVGII
                     FSFIWFFVFTFLIKKFDMKTPGREEDSEETKLYTKNEYLETKDEKGNKLSKASQQASE
                     YIKLVGGAENVVDVTNCATRLRLTLKDDSIISKEEDFKAVGAHGLVHNGKAIQIIIGL
                     SVPSVREEFENLL"
     gene            complement(27719..28504)
                     /locus_tag="KNP36_000711"
     CDS             complement(27719..28504)
                     /locus_tag="KNP36_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0872602.1"
                     /translation="MRLEEMIFLNYNKLNDTDLLIWKYITANKKHCSKMSINELAMKC
                     NVSRATITRFVKKLDLKGFSEFKVLLSWESEKVHVIENQSFDIACNSIIKYVEDQKNK
                     DYDALCKLLYESRTIYAYGSGDIQNVVAKQIKRMFLSCQEIIYDFEGRTFDDSFYNIV
                     SKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNI
                     SFLQMHPSYKLTMLYFILIELLFIKYSIYKRHRMITEGIDCKL"
     gene            complement(28671..29870)
                     /locus_tag="KNP36_000712"
     CDS             complement(28671..29870)
                     /locus_tag="KNP36_000712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S41"
                     /protein_id="HBF0872603.1"
                     /translation="MKKKVLFLVIILAFIILLGNSTYSQKNQLSEEEKVDDFNYVYNV
                     VKTGYPYLGVNKRLNNIDWLANKDEYTKRIKNTENDEEFIEELSSILSDLNNKHTEVI
                     DNKKRYELFKKSYSNNDWYDFLNDKKVVDRYDSMNLKIKMPDDIFVKKELILKDVIKG
                     QIGYMYLPSMSSKNGSINNDLKIIGDYINTLEKHKALIIDIRGNLGGSDRYWQGIVSK
                     LIKNDVKINGYRIYRNNNEIVKKYTNARNIKLNPVENLPASVKENAPKEIIKDFNDFE
                     DTSYTIKSTDDSKFKGNIYLLVDRKIYSSSESFAMFCKENKFATLVGETTGGDGGCID
                     PVLFNLKNSGLIVRMASCMYLNKNGICDEEFKTIPEFKVKDCKRTADFKDDNCIRKAL
                     ELENINY"
     gene            complement(30392..31729)
                     /gene="xylA"
                     /locus_tag="KNP36_000713"
     CDS             complement(30392..31729)
                     /gene="xylA"
                     /locus_tag="KNP36_000713"
                     /EC_number="5.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylose isomerase"
                     /protein_id="HBF0872604.1"
                     /translation="MSEIFKGIGQIKFEGVKSDNELAFRYYNPEQVVGNKTMKEHLRF
                     AMSYWHTLCGEGNDPFGVGTVERPWNNITDPIEIAKIKVDAGFEFMSKMGIEYFCFHD
                     RDIAPEGRDLEETNKILDEIVEYIKVNMEKTGIKLLWGTANMFGNPRFVHGASTTCNA
                     DVYAYAAAQVKKAMEITKYLGGENFVFWGGREGYETLLNTNTELEMDNFARFLQMAVD
                     YAKEIGFTGQFLIEPKPKEPTKHQYDFDTATVLGFLRKYNLDKYFKMNIEANHATLAG
                     HTFQHELNIARINNVLGSIDANQGDLLLGWDTDQFPTNIYDATLAMYEVLKQGGIAPG
                     GFNFDSKVRRASFEVEDLFLAYIAGMDTFAKGLLIAHKLLEDEVFENFTKERYASFSE
                     GIGKDIVEGKVGFKELESYALQMPVIKNKSGRQEMLEAILNRYIYEVDTISNK"
     gene            complement(31825..33375)
                     /gene="xylB"
                     /locus_tag="KNP36_000714"
     CDS             complement(31825..33375)
                     /gene="xylB"
                     /locus_tag="KNP36_000714"
                     /EC_number="2.7.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xylulokinase"
                     /protein_id="HBF0872605.1"
                     /translation="MKLEYVLGVDIGTSGTKTVLFDKLGNTIKSCTYEYPLIQEKSGW
                     AEQDANDWWKAVVESIREVVQSSNISSECIKGIGLSGQMHGLVMLDNEGKTLRNSIIW
                     CDQRTVKECEEITDLVGEERLIEITANPALTGFTASKILWVRNNEPDIYKNTNKILLP
                     KDYIRYKLTGEYATEVSDASGMQLLDIRKRDWSDEVLEKLNIDKNLLGKVYESQEITG
                     YVTRDVSSLTGLKEGTIVVGGAGDQAAGAIGNGIVKDGVVSSTIGTSGVVFAYTKEPK
                     IDKEGRVHTFCHAIPNTWHVMGVTQGAGLSLKWFKDNFCQSEVEVSNSLGEDVYEIIN
                     NQVSKVPTGCNGLLYLPYMMGERTPHLDPYARGVFFGLSPIHSKKEIARSIMEGVSYS
                     LKDCMDIIENLNIDVNEVRASGGGGKSKVWRQMQADMFNQDVYTINSSEGPALGVAIL
                     ALVGAGIYENIQKACDAIIKTSTKLEPISENVDTYNIYHRLYKRIYKSLKDDFKLLDE
                     VVNAKINN"
     gene            33583..34743
                     /locus_tag="KNP36_000715"
     CDS             33583..34743
                     /locus_tag="KNP36_000715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HBF0872606.1"
                     /translation="MVTDKYTIREMNERLVLEQIIKNGPISRASIASTIGLNKATISA
                     ITKKLIDESLVHEIGIGNSTHSGGRKPILLVFNKCAGISLSMDIGYDYIFSSLSYLDG
                     TIINSKKLTDIQVSKDNVIQLIDEIINSYNISKIDTPYKVIGLTLAIHGITCENKVLF
                     TPYYNLNEIDLYSILSKKYDFPIHIENEANLTALAENTFSTVHNSLLSLSIHSGFGSG
                     IIINNKLYSGRNGMSGEIGHTIIMPNGKLCPCGNRGCLEQYCSEKKVFEQLSSLENIP
                     KIDSDIVKQLYYEDNHNAKKVIHEFCSYLTIAINNAITTYAPEIIYLNSQIISDIPEI
                     LQITKDMLVSSFNKGINIEISSLGSEASLYGGSAVNIKSFLNIQNLTLINEI"
     gene            complement(34899..35303)
                     /locus_tag="KNP36_000716"
     CDS             complement(34899..35303)
                     /locus_tag="KNP36_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0872607.1"
                     /translation="MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGT
                     IEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANNDSRIKIISGLNLGMVIESAF
                     LDTKELAAKLEKIGKDNISMVEQNANLLSDDE"
     gene            complement(35324..35806)
                     /locus_tag="KNP36_000717"
     CDS             complement(35324..35806)
                     /locus_tag="KNP36_000717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872608.1"
                     /translation="MEMKGIKNIRIDDRLIHGQVATMWSNKLGVTRLMVVNDAVANNS
                     VQKQVLRMATPAGIASSIITEETAIKNITAGKYEGQNVLLIVKSPVDLIPFVEAGFKI
                     HNINVGNMSSRKDTTVLRPNISVTEEEKEAFKRLLDEGIEITTIMTPDDKKTYLVDIL
                     "
     gene            complement(35826..36635)
                     /locus_tag="KNP36_000718"
     CDS             complement(35826..36635)
                     /locus_tag="KNP36_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBF0872609.1"
                     /translation="MSDKVSLNKSNEKVKKSVLWRWFFTSSVSSNYEKMQALAYCYAV
                     LPFLKVVYKDNPEKLQSAVLNHLQFFNTNPWVAPYILGINVAMEELSSEETEEAVASI
                     KTGLMGPVAGLGDSLFVVIPWTIFGAIAANMAIDGSPFGILLWIVVSVALKLLSIPLF
                     NAGYTSGTKLISSIEKSLKILTESTSILGLMVVGALIPSVVKANVALNFQQGDFTMKG
                     QEILDQIMPGLVPAILVVIVYWALKKNIKPIYLILGVMVVSIILYALGILK"
     gene            complement(36628..37407)
                     /locus_tag="KNP36_000719"
     CDS             complement(36628..37407)
                     /locus_tag="KNP36_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872610.1"
                     /translation="MEPQLWQLLLIVLYGFFINYEKNSTMFGTYQPVTAGFITGLILG
                     DINTGLYIGGTLQLLSLGISNFGGASIPDYQTASIVATFITITTKQEASVGISIGIPV
                     ALLMVQLDVLRNTIGIWLVHKAEDGAKKGNYKNITYMQMLGVLLTAATTGIPVALSVI
                     FGPSLINTILKYTPEWLTGGLTVAGGLLPAVGIGLLLRYLPAKEYFSYLVIGFVLAVY
                     MKVPLLGVALIGGAIALIIYKKNLENQEQQYTVVGGMDEDE"
     gene            complement(37407..39485)
                     /locus_tag="KNP36_000720"
     CDS             complement(37407..39485)
                     /locus_tag="KNP36_000720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase"
                     /protein_id="HBF0872611.1"
                     /translation="MIKISEDYIEKRFDNELLRIEAWGKNSLRIRSFVDQNFVDENYA
                     LNEKPKLNKDDITINKNEDGSAIIKNGKIKAVLDHRDRITFYNDKNEILLKEYIRLRA
                     VKHDDGGEDVGTIEITKDFNSTLKLKSREYRPSYSGEFEVTTRFESEPSEKIFGMGQY
                     QHKFLDLKNTVLELAQRNSQISVPFYISSLGYGLLWNNPGIGKVSFAKNMTEWKMFST
                     NFIDYWITCGESPKELNKNYSQVTGTVPMMPENLLGLWQSKLRYRTSEEVLDVVKEYS
                     KRGIKLSSIAIDYFHWPKQGEYKFDLDYWKNPKELVKKLKEEYSVEPIVSVWPTVQSD
                     AENYNDYLENGYLVNVNRGVRMTMQIQGNTVFVDMTNENAREYVWDRIDKNYKQLGID
                     YYWLDVAEPGYSVYDFDNYRYKKGNVLSCGNIYPIDYLKMIYDGLHNDIESVVTLVRG
                     AWAGAQKYGALVWSGDIDSSFEAFNNQVNTGLNMGLAGIPWWTTDIGGFHGGNPKDPE
                     FRELMVRWFQYATFSPILRMHGDRLPHSKPLSNKGGGSMVTGAPNEIWSYGEEVEVIL
                     TKFIKIRESLKTYLKKLMKEAHEDGTPVMRTLFYEFPEDDKTWEVDNTYMLGDEILVA
                     PIMNYKDRSRKVYLPKGHTWENIFSGVSYEGGKTYEVECPLEEIPIFLKQDSSYNFKE
                     LKNILGEVKS"
     gene            complement(40284..40805)
                     /locus_tag="KNP36_000721"
     CDS             complement(40284..40805)
                     /locus_tag="KNP36_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF523 domain-containing protein"
                     /protein_id="HBF0872612.1"
                     /translation="MKRNREIVVVCHCILNCNSKVEGLSEFKGAQNIAINLINKGYGI
                     IQLPCPEMIMYGINRWGHVKEQFDNLFFREQCRQMLIPHVRQFDEYLKNDYDIKSIIA
                     IDGSPSCGYNKTCSSKRWFGELSGCNELMDKIKDIQMVDGKGIFIEELEKLLKEYNLE
                     IPIVGFDELREDK"
     gene            40971..41537
                     /locus_tag="KNP36_000722"
     CDS             40971..41537
                     /locus_tag="KNP36_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBF0872613.1"
                     /translation="MDTKKVTFSSMCIVINIVLGMVISMINIPLLFLDTVGTVLGAVV
                     LGPFWGALIGGCTNLVLGVISGPTNIPFALVNIVLGLIVGYISKKKGFGYKEAIITGV
                     ILSIVCPLIGTPISVLLFGGLSGSGADLLVGFLVQSGQKIFTAAFFPRILSNIVDKPL
                     SCIMVVYFISKMPKGFIKQYSKNTSSSY"
     gene            complement(41754..43817)
                     /locus_tag="KNP36_000723"
     CDS             complement(41754..43817)
                     /locus_tag="KNP36_000723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF262 domain-containing protein"
                     /protein_id="HBF0872614.1"
                     /translation="MKAGEIEFLSYLEGSNKSFVVPVYQRNYNWKKEQCKRLFDDLED
                     IIDSGFRTHFLGSVVSIYSMGKEYLIIDGQQRVTTVSILLIAMCQIIKEFGESKGIIT
                     TEEQIKECYLINKHSRDKDGKIKLKPIAEDRKAYYELFEEEMNTDRNSNIVSNYLYFY
                     NRIKEDNISIDDLFDAIQKLTIVEIELKNGEDDPQLIFESLNSTGLDLSEADRVRNFV
                     LMGRSSKLQEEFYNNYWYKIEKNTSSNVSSFIRDYLTIKERSIPNKNKVYFSFKRYVS
                     DNGIDIEILLKDLLKFSNYYREISYSCTDDNDVNKVLKRINKLEIFVSYPFILELFDD
                     YNEGIINKKVLVESLNLVECFILRRIVCDVPPNALNKVFMNLGREIKKFSDYKENYSN
                     ILRYIFINKKSSQRFPTDSEFSNAFETKDIYNTKSKNKLYILERLENYSNKEIVDLEN
                     LINNNMLNIEHIMPQTLTNKWKESLGDNYKEIHDKYLHTIGNLTLTGYNSKLSNKTFE
                     EKKEMEDGFKDSRLYLNKYISSIDKWNEEEIKNRTKILLDRAVEIWKYPSVTYEPPSN
                     SENIFTLEDDDVNFTNESIVSFSILGESYKAKNWTEFYEQVALTLYDLDSVRFNSIVD
                     KTYKRDFIDNIKSRDAYKLRKGIKISENIYLETNLNTEAKLNIIRFLLNEFDIELNEV
                     IFSIK"
     gene            complement(44198..47533)
                     /locus_tag="KNP36_000724"
     CDS             complement(44198..47533)
                     /locus_tag="KNP36_000724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBF0872615.1"
                     /translation="MGNFDFLQKKKNFNSFNTACLEAEKSILVSPSTCATITRRALEL
                     AVKWLYANDSDLVLPYQDNLSTLIHNNSFIELIDYDMLPLLKYIVKLGNLSVHTSANI
                     ERGEAILSLNNLHQFVSWIDYCYSDEYTAEDFNEDLLLHGEEKRTRPDELKNLYERLS
                     SKDKKLEEVIKENEELRKSLTEKRKVNTVNYDFKIDEVSEFETRKRYINIELKLAGWE
                     FGKDIGEEIEVQGMPNESGVGYVDYVLYGENGKPLAVVEAKRTSKDPKIGQQQAKLYA
                     DCLEKRYSQRPVIFLTNGFDMYIWDDYSDRKVYGFYKKSELQLMMDRRKSKKSLSSVT
                     INDEISNRYYQKEAIRAVCEALENKQRKTLLVCATGTGKTRIAISIVDVLSRHNWIKN
                     ILFLADRKALVKQAKKSFTKLLPNLALCNLLDSKDSPEDARMIFSTYPTMMNAIDDTK
                     SKDGKRLFTPGHFDLIIIDESHRSIYKKYKSIFDYFDSYLMGLTATPKDEIDKNTYSV
                     FDMENGVPTYAYEYNKAVEDGYLVDYTSIEFKTKIMEDGIKYDELSDEEKEEYENTFN
                     DDESIGDEIGNNAVNEWLFNSDTIDLVLNKLMTEGLKIEGEEKIGKTIIFAKNTKHAR
                     AIVERFNKLYPKYGGNFVKAVDYSINYVDSIIDDFSDKNKLPQIAVSVDMLDTGIDIP
                     EILNLVFFKKVRSKTKFWQMIGRGTRLCPDLLGVDMDKERFLIFDFCNNFEFFKFNPK
                     GFEGNKAETLTEKLFNIKVSMVKELQDIKYIEGEYAELRKELLEELITSVKALNEDSY
                     IVRMNLSYVHKYKNENVWSNIGAVAQNEIREYISPLITSYSDDELAKRFDVVMYNIQL
                     AYLQNNNASKGIRHVMATAEKLSKLGTIPQIQQQKYTIEKAMTENFWEDSDIFEVEEV
                     RISLRELIKYLEKSSQKIYYTSFEDMIVAEDRNDSVYNANNLKNYKKKVEYYLNSHKD
                     ELAIFKLRNNKKITKQDVETLEEILLKQLGNCDDYKKEFGDTPVSQLVRRLVGLDREA
                     ANEAFSEFLNNKSFNTKQIHFVKLIVDYVVKNGFIEDNKVLMEDPFRTVGSIIDLFEN
                     HIEERNKLIKTINKIKENASEIG"
     gene            complement(47583..48011)
                     /locus_tag="KNP36_000725"
     CDS             complement(47583..48011)
                     /locus_tag="KNP36_000725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872616.1"
                     /translation="MVIRNKLSWNSIEEVNRDFGSCLYDLQNFKILYDKEEMPELWAR
                     YIKEGFKSYMVSFLELTKAMLYYKSIDLNIKSKNFYDYLLACEYHNLLPKNSSIVIET
                     LRKLRNDDSHGYDIPQFEDMYELFTENEEVFVSIRNSCKK"
     gene            complement(48001..48381)
                     /locus_tag="KNP36_000726"
     CDS             complement(48001..48381)
                     /locus_tag="KNP36_000726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing
                     protein"
                     /protein_id="HBF0872617.1"
                     /translation="MRNIPNEIKNSIINVFPKENTLAIIIFGSYGTDKHTSESDIDIA
                     WIPIKKVPITELATKTEALRNILDIDVDLKIVTDNYTIALKKAILEGEVIYESKDFKD
                     YINKFYFENSDVIDILDWRDMYGN"
     gene            complement(48414..49586)
                     /locus_tag="KNP36_000727"
     CDS             complement(48414..49586)
                     /locus_tag="KNP36_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HBF0872618.1"
                     /translation="MEYIKLNELCYINIGKTPSRNTSDYWGSGNRWLSISDLKEKYIS
                     KSKEEITDLAVEKANMKLVPKNTVVMSFKLSIGRVAILKEDMFTNEAIANFQIKNNEL
                     ITSEYLYYALRTLNFNNTDRAVMGATLNKSKLNDIKIPYFTICIQNKMVEVLNKAQEL
                     INKRKEQIEALDELVKSRFIEMFGEPINNTKKFDMKKIKEISIYLKRGVSPKYVEQSN
                     IKVINQKCIYWRNLKVENCKYYDENLKEKIEDIFLKQNDILINSTGTGTLGRCVKFNK
                     IDNSEYIADSHVTVLRSISNNLNSDYFAALFEFTNIQDTIYRKCVNGSTNQIELSVSK
                     LGEYLIMVPPIEFQNQFSEFVKQVDKLKLKIETNLKELEDNFNSLMQKAFKGELFN"
     gene            complement(49590..51053)
                     /locus_tag="KNP36_000728"
     CDS             complement(49590..51053)
                     /locus_tag="KNP36_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HBF0872619.1"
                     /translation="MITGELRSKVDKIWETFWTGGLTNPLEVIEQFTYLLFIKGLDEV
                     ETKNEAEATLLGVSFERIFDDEHQHLRWSKFSNEGNSEKMYEIVQNEVFPFIKKLHGN
                     KDSAYAKYMGDAIFKIPTPLMLSKIVDGISNLELSKDRDTKGDLYEYLLSKVATAGTN
                     GQFRTPRHIIDMIVRLIKPTPEDIIVDPAAGSAGFLVSSQQYLRDNHSSLFLVQGLKE
                     HFNNGMFYGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSEVNTDKDKFTLVLANPP
                     FKGSLDYEAVSADLLKVTKTKKTELLFLALFLRVLKIGGRCACIVPDGVLFGSTGGHK
                     SIRKEIVDNHKLEAIISMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYS
                     LDDKRNEIKDSDIEDIIKRFDNLDGEVDRKRTEQSFFVDVEEIRENGYDLSINKYKEV
                     VYEEVVYDAPSVIIGRVRELEKEIAVGLEELERMLEV"
     gene            complement(51563..52432)
                     /gene="gatY"
                     /locus_tag="KNP36_000729"
     CDS             complement(51563..52432)
                     /gene="gatY"
                     /locus_tag="KNP36_000729"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase subunit GatY"
                     /protein_id="HBF0872620.1"
                     /translation="MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSP
                     VILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHLDHGSSFGLAMQALRVGYTSIM
                     IDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGAYTDPLEAK
                     EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIRDVVSVPLVLHGGSGIPDEVIK
                     ESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEV
                     CGCVGKAIEIVKC"
     gene            complement(52452..54368)
                     /locus_tag="KNP36_000730"
     CDS             complement(52452..54368)
                     /locus_tag="KNP36_000730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIABC"
                     /protein_id="HBF0872621.1"
                     /translation="MGKKMILGVTGCPTGIAHTFMAEEALKNSARELGCDIKVETNGA
                     IGVENKLTAKDIEMADAIIVACDKNVDMDRFNGKPVIEVPVKEGIHKANELIQRCIDG
                     KVAIRKGNLSSSKIAEEGNLSFGQKLYKDLMNGVSHMLPLVVAGGVLTAISFLWGIYS
                     FDPNSEQYNQIAATLKSVGGYSMNLMVPVLAAFIAQSISGRAGMLAGLVGGMISFDTG
                     SGFLGGIISGFLAGYLVKLFVHLLRKLPRQLEGLKSIFIIPIVSVGLVGVAMLLLGGP
                     CSALNNAMMNFLSGLQNSSPIILGIVIGCMSAFDMGGPVNKAAYVTGTMLLGQGNYLF
                     MAGVSAACITPPLVIAIASTLFKNRFTEEDRAAGLINYILGSTHITEGAIPFAAKNPL
                     KVLPVLMIASSISSILTYIMKIEVPAPHGGFLVLGLVNKPLLWVGCIFVGSLVGAVLY
                     MMVTPKVVNEKNTIENTNVTKDEHKNESAESENVSNNISLYSEETVILDVKGKNKTDV
                     IDEMIGILDKSSVLLDKKKFKEEILKREEISSTGFGMGIAIPHAKTDAVKVPRVAVGV
                     SKEGFDFESEDGSLAHIIFMIAATDNGDNLHLKTLSQLSSKLMNEEFLNELLNSKTSR
                     EIVAKLNNEEIKSV"
     gene            complement(54371..55291)
                     /locus_tag="KNP36_000731"
     CDS             complement(54371..55291)
                     /locus_tag="KNP36_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase family hexose kinase"
                     /protein_id="HBF0872622.1"
                     /translation="MIYTLTTNPAIDMNISTNGIKRKLVNRTSNAVYSPNGKGLNVTF
                     VLGHYGIESKILGFFGGFSGKYIVEESEKRGFDVLPTWVEDTTRINIFLNDGSDEFKF
                     VNSGSYVNEKQKLDMLDKIQSLADISYLSISGSLPPGIDDNYYEDIFKICKNKSIKTI
                     LDISSPKLKELLQYNPYLIKPNDEEIKDIFGIIVRDEEDIKDVLKLLHLKGAQNILLT
                     LGEKGSYFYNGKSIYYASAQPVTVVSSACAGDSALAAFLSIWLENPEHIEEALKRSAA
                     TGASVAESNGIGNLENVEDYIKNIRVRKVV"
     gene            complement(55393..56145)
                     /locus_tag="KNP36_000732"
     CDS             complement(55393..56145)
                     /locus_tag="KNP36_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0872623.1"
                     /translation="MIIELNKSNSENLTKTELEIIKFINENESILPELSIVEIAHETY
                     SSPATVSRAIRKCGLNGFNELRYRLTVKDENDDIQNMGDIINKSFIEAQRVIEQISLT
                     TLINIIKTINKSSKIYILARGLTEYVAKEFSLKLQLLDFNVVFINDPNIMKIKSKSIK
                     KDELIIIFSLNGNTIELVESAQNANLVGAKVITCCCSESAKLIKYSDLYIVGYKHEHI
                     SISEYEVSSRLPLYIISRIIIDYMVRYNNSEN"
     gene            complement(56537..57982)
                     /locus_tag="KNP36_000733"
     CDS             complement(56537..57982)
                     /locus_tag="KNP36_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBF0872624.1"
                     /translation="MIKLGKFPKGFLWGGAVAANQLEGAWNEGGKGWCLADVHMYDKD
                     RDISKPYESDMTIERIKFAMKDNNGYYPKRSGIDFYHTYKEDLKLLKELGLKCFRFSI
                     NWARIFPNGDDLEPNEEGLKFYDNLINEVIDNGMEPIVTLLHYETPLNLVLKYKGWSN
                     RKVVDFFVRYAELILNRYKNKVKYWIVINQINLIHYESFNSVAFCVDQVDNVEETRYQ
                     AIHHQFIATALTKKLGKEINSDMMIGMMMADCTSYPEDCDPENVVFALKRNRLQYFFT
                     DVSFRGEYPVYIKRFFKENNINIVMEEGDDKILKENTMDFLALSYYYSTTVSASKNTM
                     NPTDNIKNPYLKANPWGWAIDPKGLYNTLSQYYDRYQKPIMIAENGFGMHDKFEDGKV
                     HDSYRIDYLGKHIEQIGEAIADGTEILAYCMWSPIDIVSCSSQEMEKRYGFIYVDIDN
                     NGNGSKERYKKDSFYWYQNVIRTNGEELREK"
     gene            complement(58004..58357)
                     /locus_tag="KNP36_000734"
     CDS             complement(58004..58357)
                     /locus_tag="KNP36_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBF0872625.1"
                     /translation="MTIEEHIIDEELVEVAMQIILRAGEARTEIKHALNDLEKFDYRN
                     ADLKLAKAKGFMTEAHRAQTKIIQGEAGGEKRAHSLLFAHAQDTLMTIFSELNITMSL
                     VGIVKSIEYKVNNSK"
     gene            complement(58386..59633)
                     /locus_tag="KNP36_000735"
     CDS             complement(58386..59633)
                     /locus_tag="KNP36_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872626.1"
                     /translation="MGRVFMNKFIDFLSEKFTPVVNNMTKNIWVQSVQSTIMKVLPMV
                     FVGSLVTIVSVLKNYISFLPDLSPINQYTFGLLGLFIAFLLPMETMKNKKFESMSVVA
                     GLAGAGLMLMMIRPEITNEGAIFNFNRFGGEGMLVSLVAGLFSGLIMSLFGSFSFFGE
                     DSALPDFVSKWFDNMLPITVIMFVGWGLIYGLNFDMFEIIVRVFKPVSDIAQTLPGFV
                     LLNFLVVFIYSLGISGWVLSPITYSIQLGAIAANAAAVASGGVATNIYVYEVIQTGWI
                     TLGGLGATLPLVIMMCLSRVGRIKAIGRACIVPSIMNINEPVIFGAPVAWNPFLMLPM
                     WIGTVVISITTYLSMSMGFVTIPSKVFNLWYVPFGISTFMVNQDVRGLIVLAINIVLL
                     FMIWYPFFKAYEKEEIKLESQEV"
     gene            complement(59641..59958)
                     /locus_tag="KNP36_000736"
     CDS             complement(59641..59958)
                     /locus_tag="KNP36_000736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872627.1"
                     /translation="MKNIRVLLACGSGASTGFMATSMRKSAKKKGIEADIKARSESEI
                     DKYLSEIDCLLLGPHLDYMKEEIQQKANEYNVPVACISKTAYGRLDGAKALEEALELI
                     SNK"
     gene            60200..>60758
                     /locus_tag="KNP36_000737"
     CDS             60200..>60758
                     /locus_tag="KNP36_000737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /protein_id="HBF0872628.1"
                     /translation="MKTSKKELFLNFIKTQHDWIDSSTLANYLNVSTRSIRKYVNEIN
                     SNGAFILSSKKGYKVNLNTNCQTKIDSSENISPDNRLNLILKELIVNSNGINIFDLSE
                     ELFVSPATIEGDIVKANKFIGSYNLKIKQSKFLLKLVGNESAKRKLMSSIIFKETGSD
                     FLSLFDVQKIYQEYNLTKLKENIIYI"
BASE COUNT        19784 a        10796 c         6233 g        23945 t
ORIGIN      
        1 taagaaaatt tgttaagttg attgaatact tttttatgta tttaattaat tttataaatt
       61 caattatttt ctaaatttag gtatgcttta ctatataaaa atgatttttt atcttaatct
      121 tctgaatata agtgaatgct atcattttaa gtatcttata agcaatgtaa ctatatatct
      181 ctaataacta cttttttaac atgcttaaac tatttataag ctattatatt tatgtattaa
      241 cctaataact ttttcactaa aaaataacaa tctattcaaa gataaactat agtacttctt
      301 ctactttgtt tcaataaaat actaaataaa tttcgtacat ccacaatttt tcaggctaca
      361 ctataaatat acaatattta tcttagttat aagtttaaga atatttttag tcttattttg
      421 tcgaatatct ttttaataaa acttcataat tctaagcata tttttacact gtgttttcat
      481 gtacaaaaat aatgcttaca aataaacaac ataaataaaa cttaaataag atggattcta
      541 ttcaacatag tatccatctt attcattcaa aacctaaaag gattttttat aatattatat
      601 attttaaaat ctaagtaact cattatagta tcaatttcac ttaaagctta caatacactt
      661 attaatcttg ttttatatta aaaacatcta caataacaat ttaaatcttt aagtgatatc
      721 catctcacac ctaaaggagt aggctctccg cactattctg taattcttca atacaatcat
      781 tattattttt tatataattt aattatatat tttattttac caaaaccagc atacataaat
      841 aatacttaaa atagattaaa taaaggatac taaaacactt tattgaggta tatgacttga
      901 aatatatgaa ctaacttcat taggagaaat atctaaaata gttgcaaatt cttcatttaa
      961 taacctttca gcttctttca ttatattatc atctgcttga tgtgtttttt taccaataga
     1021 ttttacatac tctctgttat tatctatact tcttactaat tttattaact cttcacattt
     1081 accacctctg agtatttttt taaattgctc acttctcaat ttttcattat ctatccatga
     1141 tgtatccata ttaggaatat catttattaa tgaaagcaca ttaattttag aaagtaactt
     1201 tctcattggt actttttcat tatctacagg aatttttatt actgtattat tagaataaat
     1261 aggactcaat acataatact ctttttttat tccatttgta aatcgttcat ttgttatatc
     1321 catgactttg cagactcctg tcataccata cattatataa tcatcaatct taaacaaaaa
     1381 catcaccatc cttaataaaa aaaatagttt tgacaactaa atccaccttg ccaaaactat
     1441 ctgctatata ttatatttta acacattttg agacttaaat gtaagtaaaa cttatattat
     1501 taaaattaaa aaatacatta accattgatt aatgtatttt ttagattttt ataacaagca
     1561 tatcaaaata aattaataca gcttatctcc tgtgaatacc tataaaattg gtgcttggct
     1621 attcattgag tacccatcat ttcttacatc atttatttct aatatttcat catttgtttt
     1681 aaccttagta agttttttaa ctgctccata aggttctttt aatgaaattt tatctcctct
     1741 tccagaaata acccataaaa ttttgtaccc tctaggtatt acttgtagtt tattttcacc
     1801 tttaccatca gtaaagtaga ctaacaaatt aatcttttta ttattagcat actcaaagac
     1861 tggagaaaat ctagtacctc cacctatcct aattctatct tttatatctt tttcagttct
     1921 cactttatat acacgtctaa tttcattatc acattctata attgtaattt catgattata
     1981 gtttttcact atactaagaa cttctttaat agcttgttta aactcttcat cactaatact
     2041 tccacttaca tcaagtgcaa ctgctatttc tgacttatga cttctaagtt ctcccctcaa
     2101 atctaaacga tttggttgtc ttctatttct tcttgttata gtcttctttt tattattttc
     2161 aactgttccc attattctat taagatataa attccatggc aattcaccct tactattttt
     2221 aagtgatgat atcatacttt ctaaataagc aggaacttta cctttttgag aactgttaat
     2281 aaatttttca gtaaattctc taagggtatt ttcatctatc tcattggatt catcccatat
     2341 atcatgagtt ctttcggggc tataatcaat ttctatatct ccatatttat cactatcatc
     2401 ttcctcacca tcttcatcca cttccatcaa atctaattca gtctgaatct tttctacata
     2461 atattcaaaa ggttcatatg gttcaagttt taaggaatat tttaaattta cccactctaa
     2521 ggtagttgca tatggtggta aattgtttag aaatttattt actactatat ccattgccat
     2581 attaattgct aatgtactat actttccttt taactccttt gctctcatca aatgcataga
     2641 taatatatga tgaatttcat gtttaattgt agtctccatt tgctttatgt caagcgttaa
     2701 aaagattatt ggattaaaat atataatata tttagctccc ttaaaattca cacctgtagg
     2761 actacttata tcaaatctta tttctcttga catctgaaac aaaaaatatc cataaaaatt
     2821 atcttcttct tccataagac ttaaattcac tttatctaca agactaaaaa actcatactt
     2881 aaaatcttgt ggtatatcta tatcaaattt ctcattagca cgatttgcct ttagcataga
     2941 atgagtattt ataatttcac ttgctttatt ataaagctct tttgcttgtt tatcaaaata
     3001 attttccata cattatcccc ttattaaact ataagattca aaatatgatt ttacaaactc
     3061 ttcattttct atagcttttt tatatacttc aatataactg tttctaatat ccttcataat
     3121 acctatcatt aaatctacag gatacatttt taaaaattca ataaatctat taatatagtg
     3181 gtttgattca tatttatcat tcttaatatt taattctaag tcttttagaa tgttcatagc
     3241 tgatagataa agtcttgtat gactctcatt ttttactctt tctacaatag actcatcaat
     3301 agattctcct aaaaaaacat cttcatagga tattaatggt tcagagtttg attcaataaa
     3361 acttataaat tcttctgcaa taactttacc tacattaccc tttacaacat ttaaaaatac
     3421 tgctctagga atagaattat ttttttcttt ataaacttta taaattttag atactctctc
     3481 ataacttcta ggagtggctc ttacatcatc ttcatttatt ttatgcagat attctggaaa
     3541 agtggaaata aactcgataa cttttctttc aataccctca tctattgccc attttatcca
     3601 ttgtgtatgg tcactctcca tatttaacca aacaaaccta ttttcttggg ctgcatccat
     3661 atctaccact tgataatcaa aatctgaacc atatttactt gatggattca ttgctgctaa
     3721 aatctttaca tcatcatgca gtttatatcc attaatttct ctatttaaaa ttaaattcat
     3781 aagttcttgc tgtactgtat gctcacaacg atttatctca tctataaata aaagaactgt
     3841 cttactttta gatatctctt catcaatttc tcttaatttg ttatgaacag catacactgt
     3901 tgttttcttt tcagtcttat atccattaga attaactcct acataagatt ctatagttgg
     3961 aagaccacct atttcaccct ctttaagtaa gtttccatca ataacaatta aactccaatc
     4021 attttctttg gcaagcttat ttgctaaagc tgtttttcct attccacttt cacctactat
     4081 taaaggtact tctccagtgg ataatattaa gtcaacgctt tttaatgtgt ctataaaatt
     4141 catttttctc tctcctacat aatctttaat ttctcatcta cagctatttt ttttgctgtc
     4201 ttacttccat atttataaat aaacataatt ttatctattg gtatactttc gctatttcta
     4261 tctataacac tacaattcaa aaaatctcta atatactttt cctcaacatc ttctttggat
     4321 aatacttctt ttaatgcact ctctaattca tctttagata cttttttcag aatgtactta
     4381 atcactaaaa tattcacttt taaaaattcc aacattttat ttttatctaa atcagttata
     4441 aagctaatag ctgcttcatt attttttata gctataagtt ctgcattata actaggtgaa
     4501 tctatatatc tcaaggcatc ataacttatt ctcactgcct cctcttgtac actttcataa
     4561 ggttgtttta taaactttat cgaatcataa ttttttctta ctgctaacag ttgtaattct
     4621 tcacttggat ttttagcata tttaattgcc catcctgctt gatttatagc catttcaata
     4681 actttatcag ttgggttttt gatataatcc agtatactcc atccctcatt tactgctttt
     4741 atcatcatat cttctgttgg attatctata aatttaattg ctctaatatt attatctatt
     4801 gctagttctt gcatctctct ggttggatta tttatatatt ctagtacaag cccattttct
     4861 ttaatagcta acaatttcat ttcatcagtt ggattatcta ttgtagctat aatattggga
     4921 ttatttttta tcatttcaat aactctcaat ttttccataa tgtgcctttc cttctataat
     4981 tatttttata tctatattaa ttataataat ctattcctat ttatataatt gtttcttatt
     5041 ataattaata tactttttaa tcaaatttaa acagaataat tataccaata tataaaaaaa
     5101 tttctaaaaa acaataaaat taagttataa acaccaatat atttctatta tttcaataag
     5161 tatacaatta gattagaatc taacgctagt aataaaaaat tactttccca aaatagatat
     5221 aagcctcatt ttatcgttca aataatgaaa atatatttga tttcatgcaa aaagagtgcc
     5281 taatgaacta aaaagttcat tttgagacac tcattttttt atataaattt atatagtttt
     5341 taatcgttcg cattcaacca ctcagttaag acttttatat atttctcatt ttcttcaacg
     5401 aatggcatat gtcttgaata ctcaaataat tcccacttac tattaggtat tctatcatac
     5461 atagtctttg caatatatgg tgaacataaa tctattgctc cactagttac tagacaaggc
     5521 tcttttattt catgtaatct atctgtaaat tcatatccag aaagagttcc tgtaggagaa
     5581 aattcatttt gtccccatcc tacaatatat gcttcagaac ctgatttttt aggtcttctc
     5641 aggcactctg gagaatcttc tgtcacttca cctgcacaat acatttccat aaatctttct
     5701 aatgcatcat tatattcttt gctagagtaa tctccagtat ttactgcatc aagtaatgct
     5761 ttttggtcaa cctcactcat atatgatatt cttctttttt gttctttctc ccaaagtttt
     5821 gcagaagaaa gagtagatga aaggatgtaa gacttaatac cttttggttt atattcaata
     5881 gcataccaaa tagcctgcat acctccccaa gattgaccta acagatgaat ttcatcaagt
     5941 cctagatgtt ttcttagttc aataagctcc tctatccaag tatctgcatt aaatagctca
     6001 ggatgccctt ctacaaatga atttccacaa ccaatttggt catacattat tacttgtcta
     6061 ccactttcag ctatcttatc caatacctca aaatagttgt gtgtagaacc tggacctcca
     6121 tgaagtaata ctaatggctt cttcccttcc gtattttctc ctactatacg gtaatacgtt
     6181 ttaaaacctt taaaaggcat atatccttca gtaattttca tgtttatctc ctccaatttg
     6241 taattataaa caataatcaa gttcattaac aatactattt aaaacctctt atacatattt
     6301 gattatgtat tttaatcttt atacctactt ttataaatag tataacataa aagttaaaaa
     6361 tctctatact aaaccaatta taaaattata ttaactatat aattttattt tttaataata
     6421 gtatatacat atttgattat tttcatttgc tatttaaaat caattttaag ttttcttctt
     6481 ataataaact tcctctttgt ggtctcatgt tagtctctaa atttaaaatt ttacaaaaaa
     6541 ttttcataaa ataaaattat attgattgta tctaaacaaa tagggcaata aaataattaa
     6601 gtatagttac ttacctttca agcaatatta gttttatgtt agaattttat tatattgatt
     6661 tacaggaggt ttgcatttga ataatattaa ttcacttaaa gtaataaaat tatctcttgg
     6721 atgttctctt gctatattta ttgcttggct attaaaatta gaatattcaa tggttgctgg
     6781 agttatagta ctacttacag taaaggacac taaaagagaa actcttaaag gctccattgg
     6841 aaagatttat ggttttcttt tatgtactat tttttcatat ttatgtttta atattttagg
     6901 atataatttg acttcatttt caatatttat atttataatt ataccacttt gttttttgtt
     6961 aaatattcaa gatgttattg ctatgtgtgt agtcatagca tcccattact accttcaagg
     7021 agaaacttct atcaaatgga ttttaaatga agctggaata tttgcagtag gaactggaat
     7081 aggtgtctta ataaatatgt atattccaac aaatatacat aaaatccatg aagttcaaaa
     7141 aaagttacag gaagaagtga gtattgtact tatagacatt gcagatatta ttgtaaatcc
     7201 taaaaaagaa aatggatata gtagagattt atatacatta aattcactta ttgacagcag
     7261 tatttctgaa acttacgata atattaataa tactttatta agtgatacta gattcttctt
     7321 agagcatatg gatattataa aaagtcaacg ggatatctta gaaaatttgt atagttatgt
     7381 atctcaacta aattctacac caccacaagc tcatattcta tctgctttta tacataagat
     7441 aggttatact gaatttgaag ctgaaacagg caatcttctt cttgaagaat taaagagact
     7501 aatgcttagt atgaaaaacc agcctctacc tgttgacaga acagagtttg aaaatagagc
     7561 tattttattc ctatgcttga ctgagttaaa acagttttta gttaatcgta aacatgctca
     7621 gatgcttaga gataataatt tttataaata aaaaggggag aaatctagca gttgacctga
     7681 ctacaaaata tcagatataa tattaaatgc gcccctagta agagggcgca atgtttataa
     7741 cttattctac tgtcatgatt aaatcattat tcatatcgaa catacattat ttgaccaagt
     7801 ccaatattag ctttttcatc agtgatttct attttaatag tcacatcatt ttttttacag
     7861 tacttcgcta attctgcacc agaacgattt ttaccactaa aatctaaaga aaatggctta
     7921 tcatatttaa aaggatattc aacaggttta ccctctggtg ctaatgcaaa catcccatat
     7981 ggtgtgttca taaatcctat tacagcaatc gtaagatttg atgggtctaa atttgattca
     8041 ctacctgtaa atgtaattgt atttactgat gaattaacta cactacatcg aacaccttca
     8101 tacattacat gtttttcatt tatatcttct ccttttttcc caaaatttcc aacagccttt
     8161 gccccttctt gatgtggtaa catagtgtgc ttcccaggtg gtgctggttt ctgtgtctgt
     8221 tctggtttta ccgtctgtac tattgcacca acttttggat atgctgtctt atcaaatggt
     8281 aatgggtggc taagactctt gtatatgata tcctttcctg ctgatttatt agcatcaata
     8341 tctacatgat acaaacgccc atcaccaaaa cggataagat tccactggtg gtcatttgat
     8401 gtgctgtgta cataataaga ttcaattccc atagcatcac acaaagcttt catgctccta
     8461 gccattcctg agcatgcacc ttttttagta accaatgtat aggcagtatt tgctccctct
     8521 actgcattcc agtcaacata tgttgtgtta tttttaatgt gattgtaggc aactaaaatc
     8581 ttagcatctg tggtcatatt ctttgtgatt ttcttgttca taaaatctgc tgttgcttgt
     8641 gctactgagt ttagttgggc ttgtgacagc tttggaccat atacgctatt ggttccagtg
     8701 acatagcttt ttggtgtttt tgctgttacc tctttggctg tcataccata aactgtcata
     8761 ctcatacctg agattaaaac tattgttgta atcaataact tggtagctaa cttcctaatt
     8821 ttcttcatac ttaatattct cctttataaa acattgttac ttcctattct ctaccattaa
     8881 taaaattaat ttaggattta aaaaggtgga ttgtcaacat gtatatttct ccattcatac
     8941 attcgtgaaa tatttaaatt tcatggaaaa tctaatagat attttctaga taatttgtat
     9001 acaatacaac tcgcaaatca gggtgtttgc tgttagtttg agaaaatgat gatgattaat
     9061 acattcggaa tctttgacct ataataaata ccattgtctt caatcattaa taatggtaag
     9121 agtaaagaga attatcaata atacagttaa aatcaacttt gtatacattt catacattct
     9181 ctcccaacaa cattatactt cttataattt gtatattcaa tacgttttct gggaaaatat
     9241 aggatatatc tataaaaata taaaaaagga gttgaactta aaatttgatt aaaaaaaatc
     9301 aattttaaga caactcattt gtattataaa aatgctatat attattatta agtaagtcaa
     9361 tattttagat atttatctat ttcttattga cttacgctta tagtctaact tatttgttta
     9421 gttgatatat aacctagttt taagcattat taatatttaa ataatcaagt atcctttttg
     9481 tttcttgtag tttctgttct gcctcattta agttttcttg aattatagaa atatatatta
     9541 tatctatcaa cgtaagcatt gctattcttg aagaaatagc tccttctcta agcctttttt
     9601 ctatatttgg tactactagt tttaaatcac taatcttact aagatgattg tcactatatt
     9661 tagttataca aatgacctta catcctttta attttgcatt ttctatagac tttattactt
     9721 cttttgattc tccagagtaa gatattgcta tagctatatc ttctttatct acatttgaag
     9781 ataccataag ttgtgtatga ctatctaaag aggtaaatgc ctgtttattt atccttaaaa
     9841 gtttcatctg taaatctagt gcaactaaag ccgaaccacc tactccaaat atatatacat
     9901 ttttagcctt tattatctgt tcaactgctt cttttattat atctttttca ttcaacaacc
     9961 ttgtttggtt gatagtctct atgtttttgt ttgtaatttt gtttataaca ctatctatat
    10021 tacaatcata gttttcatct acatatgtgt attcattttc tttgcccatc aaatctttag
    10081 ctatctcaat ttttaaatcc ccaaaacccg aatatcccat ttttctagaa aacctaacta
    10141 tacttgctgt acttgttttt gagtttgacg ccaattctga tacagaaagc ttacttatag
    10201 cctctgtatt attaagtatg taatcagcta tttttttatc tacttccgtt aaatcttcat
    10261 atatctgttt taattttaaa atgcaactca tactctatca cctctaccta tttactataa
    10321 tatttcttct tagcaagtaa acatgctcct aaatctggag tcaacactgg tctcactata
    10381 ccaaatctcg ttttattcaa atatttttta agtggctcta atattaaatc tcctgactta
    10441 aacactccac ctgaataaga tacctttatc tttgtacctt gttcaaaatg atgctctaat
    10501 cctattataa gcctacttaa ttcataagct gcatcatcaa atattttact agcagtatta
    10561 tcaccttcaa taactgcttt taaacatatc gtagcaaact ttgctatttc tattctatct
    10621 ccttttattt catcatttac atattttatt atgtcataat cattctctat attaagatgt
    10681 ctttttatta aatcatataa ttttgttttt gaacaccttc catcagactg cattgtgaac
    10741 atttttaagg tagccattcc tatataatac gctgaacctt catctcctaa tacatagccc
    10801 catcctccac atctgtgaag attcccatct ttatctaaag cctgtgctat tgaaccagta
    10861 cctgcaatta tatttatacc tttttcccca tttaaagaac ctgctaatgc tatttctaca
    10921 tcattaccta gagtataatt tatatgacta tatgcatttt ttgttgctac ttctaatgca
    10981 tacaatactt cttttatttt tccatatcca gcaagtccaa caaatgcata cgttatttct
    11041 tctacattta tcttagcatc tttacaaact tcttccaacc cagttattaa taatttcgtt
    11101 agattatcaa atcctatttg attataatga caagttcctt tggttatggt tcctactata
    11161 tttaattctt catctactaa tgtaaatgtt gttttcgttc ctccaccatc tacacctaaa
    11221 aaatacatac tatcctccta caatatcttt aataattctt tcaatactta atatctaaaa
    11281 ataaccttcc aatgctgttt ttttaatatt gaaaggttat cagtactatt atttatttta
    11341 caatttttct attgatttta aagcttcact tatataacct tcttgtctat ctaggatact
    11401 ctttgcacta tccttatcta aaccactttt tatcataaat atagccaatt taacgctatt
    11461 atctgcttct tctaagaatt tttctgcaac atcatatttt acatttgtag ctatcattat
    11521 tattcttttt gctctttcaa ccaacttttc atttgatgtc ttaacatcta ccatcaagtt
    11581 tgagtatact tttcccatct taaccataga agctgttgtt aacatattac ataccatttt
    11641 ttgagctgta ccacttttca ttctagttga acccattatt acttctgccc ctactataat
    11701 gtttattggt aaatccgctt ttttactcat ttcactattc ggattcatag ttattgatag
    11761 tactgcacac cccaattcct tagcatactc cattgcacct ataacataag gagtccttcc
    11821 tgatgcagct ataccacata taacatcctt agatgtaact cctctatcta ttatatcttg
    11881 ctttccaagt tctttatcat cttcagcacc ttctattgct ttaaatattg cttgatttcc
    11941 accagctatt atagcttgaa caagctcaaa atccactccg taagttggag gacattctgt
    12001 ggcatctagt attcctatcc tcccactggt acctgctcct atatagaata atctacctcc
    12061 ctgtttcatt ctatctacta ttatattaac agcttttgct atactctcct tttgttcttc
    12121 aacagcatag gctacagttt tatcttcgtt atttattaat tctattatgc ctaatgtatc
    12181 ttctttatct atttgcaatg tattcttatt tctaccttct gtaactaaat tttctaaagt
    12241 ttttattaac atatcatttc ctcattttct taatattaaa tttttaaaca cattttaatt
    12301 ccaactttca taattatatt tttataataa attaatattt tcataataaa ttattttgtt
    12361 gagggtttaa aattaaactt ttgccatggt ttaatataat ctaatataaa taattcttct
    12421 tttcttatat atcctactac attcgattta ccactgtttt tcatatcagt caaggctatt
    12481 tgtaactccc ctgcataatg accatattca ctactttcaa ttactatatc tcctcttttt
    12541 attattttag gagtattaaa tagttcaaat ttatatcctt tatatttaac acgagattga
    12601 gtagacctta tcagactatc agatatgtcc cctctattaa aatgtatttc ttcaaagagt
    12661 atcttcttct caacttctcg tatattttcc tctattgcta catcaaatgt aaccatatct
    12721 tttctcatag aacctaatac ctttagctcc tcatatgttg gataacaatt tgatattatt
    12781 atatcattta tattattcat agctattata tgctttactt gaatatctat aggtagattt
    12841 ctgtgcatct caattgttgg aagcccatca gttacaggcc atggtccaaa tgtagtttca
    12901 ttttgacttg ttacaaaaac tgctgttctt aatccatact tattaaatct ttctgtacat
    12961 tttataaagt gttctaaatt taatccacta tatctatgtg gataaaagtt atgacatcct
    13021 atcaaatttt ctttatttgg ttggtagtcc attattgtat ctatataatt agtattatta
    13081 ctcatattga tttctatttt aagattttga ggattaaaag tcattaatgc ctcttcagaa
    13141 cctgtaaatc ccatatcaag ccttattccg tctgccttcg tctttttaaa aaaattcaaa
    13201 tctttgtagc ttatttctaa ttcaccaaat actctgggat ttacatcaag tattacctca
    13261 aaacctttaa acttagcgta ttcatttata cttttaaatt ttttaattat attttcttta
    13321 gtatctttaa ctgataataa acatgaaaat atacgtgtaa atccattttc agcagcttta
    13381 tctatataat catatatttc cttagatgtt gttttttctg gataaattga tattcctaat
    13441 cttcccatct gtgtcatctc cttatatcct atatgtgttt aaatttattt cgaattacac
    13501 gaaacttttt taaaaatttg atgaaaaaaa gtttcatata tatttataaa aaaagaaaag
    13561 tttacctttt ctttttttat aaacaatcaa caaaatatct tcgttactta tttcataact
    13621 gttatacttt gaaatttata ctaatctaat atagttttta atttccaata tagtttctaa
    13681 ttaataagct tcttgctctt caactttttc ttcatgaagc aacctcttat cgtacatctt
    13741 gacaaatgga tagtaaatta ttattgatat agctatacat aataagttaa gaactgaagc
    13801 tctccaatct ccaccagtgg ctaaatatgc ccctactggt cctggtaatg tccaaggagc
    13861 agtaactact actctggata ctaaattagc actcatagca aaccatgaaa ctgttgccat
    13921 tactattggt gctacaacaa atggtattat taatattggg tttaatacta ttggcgctcc
    13981 aaatattatt ggttcattta tattgaatat tgctggtatt acagttgctt ttcctaaaga
    14041 ctttccataa gctgattttg ctctaaatgc aagaagtaaa gctaagccta ttgtagctcc
    14101 agaacctcca atccatataa accattgaaa aaagggttca gcagcaatac ctggaactgc
    14161 ttgacccgca gcatatgaag ctgtattagc atctaataat tgtatccata aaggtcttgc
    14221 caatgaacct attattgata caccatgtat tccaaatgac caaaaaaacg ttattaaaaa
    14281 tattagtata attactgatg gtaatgtgtc agtggctgaa actaatggag ttactaattt
    14341 agctatgaag ccatgccaat caaaccctag gaaataagta acaatagcca ttaaaattat
    14401 tattaatgcg gctggtgtca gagcttcaaa agaccttgtg actgatgctg gaactgcttc
    14461 tggcatggtt atcttgaatt tagatttgtc agtaaatcta taaatctcaa cacctattat
    14521 agatgttaca atagcaacaa acattgaacc tccaccaaga ttagccattg gcatttgcca
    14581 tccttgagga attgaattat accaagctaa aagttctgga ctcttttcaa ctatctttaa
    14641 taaatcaggg gtaagaccct ctattgcagt aggaactatt gtcaaaagga atgtagctgt
    14701 agctaataaa cctcctgtca atccatctaa cttatatgac tttgccaaac tataacctat
    14761 gccaaatgta gaatatactg atataataaa aaatgtcatt ctatatggta gtaatattgt
    14821 aactgcattt tcctttagat actgagttac cccccatgaa tctggtaatg gaggaaatgc
    14881 taatatcaag aaaaatgacc caactattat aagtggtaat gaagctacga ttccatctct
    14941 tacagctctt aagtgacgtt gttctgccaa tctggccata gaagttgata atttagtgtc
    15001 taaaaattct gtaaatttat ctagcatctt ttctctcctt aattaatatt tatttttatt
    15061 atcattaaaa tttttataaa attaactttc ttctaatcta acaacactgc aactactatt
    15121 tactcaacag ctcttgaact tgttttaata actttggtcc tcctaatgga ctataagctt
    15181 gtgcttgtat taatgcacat ggtacactaa cctcatcagc aaaagctttt aaatagtcaa
    15241 atctatgtct aacttgtgga gctaccatag caatatccca tccattttta acttcatcct
    15301 caaactcttg agtaccaaca gccaaaacat ctatatctat tccatttttt gctccttctt
    15361 tttgtaatgc attaactgct atagcacttg acatccctga tgaacaaaca aataatactc
    15421 tcatattgat tccccctgtt tttttatttc ttttcaatca ttatagcatg tatttttgat
    15481 tacaggaata cgtttgtata tatttttttc atattttaca ttttaaattg taattttatt
    15541 tcatacattt atatcttgct ttaattgctt tatttatcta atcattcttt tgtctaaaat
    15601 tacacactac ttaaaatact catatctttt cttaaaaaag aaaaaagact atcttattat
    15661 taacataaaa tagtctcaat acttttttaa atatgtattc ctttatatat ccagaagtaa
    15721 cctattattg caaatgataa agcaaataaa atatacagtc taaaaaatcc caaagaaaaa
    15781 cctctcttag tttcaacaaa gtatcttgta tatgcaactg caaaagatgt aattaatgaa
    15841 tttcctataa caactccaaa tctattatct attccaaata tagataataa caaaggaaaa
    15901 actacagtac ttactagaga tgaaactatt aatattaatc cacttttaaa acttatagtt
    15961 ggaatattat aatctgttct ttgatttttc tccatttgtt tcttagtatt tttattactt
    16021 tttgtacttt ttgcattttt ataattatta tttttctttc ttttcttttt tttattatta
    16081 gacatgtcat ttacctccaa aaggtttagg tgttatattc cctaaaataa ctttattttt
    16141 agcccctgtt gcagatatta cattagaaaa agaattattt aatgtttcat tgcccaagat
    16201 tacaaatgcc aaagcctcct ttgcatcaga agaataccca tattcatctt gagttaatac
    16261 ttcaacctct aataataact cttttatata tcctattaaa gttagattat gagctcctcc
    16321 acctccaatt aataaagtat ctacattaac ctttggaagt atgaagtttt tataattata
    16381 atatatagct tttgccgtaa acatagttac tgttgctatc aaatcatatt tatctacatg
    16441 tttatatttg ttaagcatgt tatccaaata aacttgtcca aatacctctc ttccagtgct
    16501 tttaggtggc gcttgactaa gatacttatg actcatcaaa tcttttaaca tttcttcatt
    16561 aattttacct tttgatgcaa agtatccatt tttatcatac tttctattaa ataatctttg
    16621 acatactcca tctattatca tatttcctgg tcctgtatca aatgcaaata catcatctat
    16681 gttacatgat ttaggtatta tagtaatatt tcctattcca ccaatatttt gaagtgctaa
    16741 atttttattg ttatcactat ataataaaaa ttcactatat ggtactaatg gagcaccttc
    16801 tccacctgct gctatatcca ttactctaaa attagatatt acctttgtat ttgtttcata
    16861 tgctataact gctggttcac ctatttgaag cgttgaagat acaaaattat tataacttct
    16921 tggtatatga aagattgttt gaccatgaga tgcgataaaa tccaaatttg ctatatgaaa
    16981 gtttgcttta tgacacactg attttacagc tttactaaat aaatatccaa gcttaaaatt
    17041 taagctacag attaaatcaa cactcgattc ctcttctata cagcactttc ttatttcgtc
    17101 ttttatatct ttaggaattt ctagagttat aaattctatt tgcttaactt tagtatttct
    17161 accattccca ctaatttcag ctagtactgc atcaactcca tctaaggaag ttcctgacat
    17221 taaacctaca ctatacatag ttatcatcct tttaagttta tagttattcc tccccaaatc
    17281 aaggtattaa gtttaataat tttagaatta atcttatttc atctttaatt acgataattt
    17341 actcttatga aattaattga gttaatctta tacacgtttt ttaccttagc taaatcttac
    17401 attaatttat tttcagtgtc aatgtaatac catgtaattt tttttcacaa acaaaacata
    17461 ttctctctcc aaaaaccata ttaaaatagt tactacaaat aaaaaacata ccaggtacct
    17521 atctgatatg tttttcatat ataataatta ttattttata atatagatag agcatcattt
    17581 aaggcactaa ttaaatcttc actattttca agaactaaat ttattcttat tgtatatgtc
    17641 gatttgtata tgatgataga ttttatagtc taataaccta actatctagg cttaaataat
    17701 ccgatatatc ataaaaatag atattaaaaa ttgtatatga accattttcc gaacatacct
    17761 caatctcatg ccctaaacta tctatcattt tctttacaaa atacatcccc attccagtag
    17821 acttatacaa ttgatttctt ccatttttcc ccgtaaatcc cttgtcaaaa accctagata
    17881 tatcttcctc atttatacct ataccaaaat cttttataga taataccact ccattttcta
    17941 acttttttga attaaattca atcttaccaa cttcctttga atactttata gcattattaa
    18001 taatttggtc taaaacatat gacatgcatt tagaatctgt gtaaacatca ttttctaatt
    18061 cattcaaact aacttctaca ttatttttta taagcaaaaa tgaattattt tttatagaca
    18121 tttttatcaa tttttctaaa ttaaatttat ttataaatac atcttcaaac atagtgttgc
    18181 ttctactact atacaaaata gagtttacta aaaaatttat ctttgcaacc tgattcttaa
    18241 tatccaaact atcttctatg ctacttaacc tatctgtaat tatacttaaa gaagatattg
    18301 gaatttttat ttcatgaacc catttagcta tgtactcatc caattctttt aatgattgtt
    18361 tataagtctc tatgtcacta ttatttttta tttttaagtt ttctataata tcttttatta
    18421 gattttcttc aaaagattgt ccatcaacta aataactgtc tatttcacca ctattttcta
    18481 tacaattata taaatttgtg taactatttc taaaatttat ataatctata acaaaaaata
    18541 ccattattat aaacagtact aaaaaatcta aatatattaa ctctgaatat ttatttttaa
    18601 aaatatctat agcaaataag tagatattta ttatactaac tacaactaaa ggtagagcaa
    18661 tatacttaga cctacctttc aaatatttta ctagcattgt attatatatc ctaccccctt
    18721 cttagttttt ataaaatcat caaaacctag ttctttaact ttacttctca atctattcat
    18781 atttacagta agtgcattgt ctgtcacaaa ctcatcatta tcccatagag tcatcataag
    18841 actttccctt gatacaaccc tattcttatt ttttaataat aatgttaaaa tttttatttc
    18901 gtttttagtc aactctatac ttttatcctt atacttatgt tttataatcc ctttccccac
    18961 atcaaacatc aaatcttcac aatacaaaat actattagaa tcactataat tatagactct
    19021 tcttattata ccatttattt tggtaaccaa tatttctata gaaaatggtt tggtaatgta
    19081 atcatctgct ccattattta tacccattat taaatccata tcagaatctc ttgatgataa
    19141 aaatattaat ggtacatttg aaatagctct tattttttcg caccagtaaa atccattata
    19201 taatggtaaa tttacatcta aaagtactac atctggtttt ttatctataa attcatctaa
    19261 tactacctca aaatcatcaa ttaattctac tttaaatccc catttttcaa gtgctaatgc
    19321 aatctctttt gataaatcaa tatcgtcctc tactaataaa attctataca tttgtatatt
    19381 ctccattatc ctaatatttc actatgctat gaattattaa tatcataaca tattttatat
    19441 gaatttatta cccaaattat ttagttaatc aacaaggaga ctcttattac aagaatctcc
    19501 tttctcttta ttaatatatc aactaatttt tatacactac actcttaaac ttattaacag
    19561 atactgctcc atatattatg aatattatca aacatatcac taaacttagt atatatatac
    19621 caaataaatc ggtcatcaat aaatctcctg ctaatctcaa tgcaaaataa ctagatatag
    19681 ttgcacttaa cattggcaaa gtataaaaca tagctacttc tttaagtata gctctattta
    19741 tatctttttc tgtagtacct atttttaaca aaatcttata tttctcttta tcttcatatg
    19801 catcactata tattttcata tatattatac ttccagctac aattgcaaag actaagaata
    19861 aaaacacaag cactacatat gcaaacttca tccattgact ctcaccttga gctttatatc
    19921 cattttgaat atacccattt tttaaactta aattcttttc aatattgttg aacattactt
    19981 gactattttc ttcttgaaat acctttgcac cataaaaata cacttgttga cccttatctc
    20041 ttagtttaaa atatgtatca tcatttacca ctataatact ttgattaagt cctgtcccta
    20101 gtactggaac ttttacttct ccccttgaaa tattatataa ctgaccatca agttttatct
    20161 tggcttcttt tgtagctatt gatgctatcg tttgagggct ttttaactct attacattat
    20221 ttccactaac taatctttca ccatactctt ttaattcttt atcattgcca ttcactttaa
    20281 gagtattaca aaaatcacta tatttcatta tagtatctgt tgtatcataa gcttctttta
    20341 tatctgtttt ctttaaaatt gttagttctg gatttactga gtactttatc ttattagtat
    20401 cttttattat attctctatt tgttttttat tcacttcatc tttatccatt gaaactatgc
    20461 taatagtgta cacatttctt tgttcttggg cattcttatg tatacgcttc atcgcaactg
    20521 aagcaccaag agttgatatt gttgtagtta taattatagc tattatagca taagttttat
    20581 agtttttatt taatcggtag tttatattgt ttattgcaat tatattattt ccattaaata
    20641 atattttttt atttttgatt ataatatcaa atataacagg cataactgat ttgaataatc
    20701 cataagtacc tactattatt atacctataa caggtagtac actagttata tctccagttc
    20761 ttatattggt agaaagatag tagccatatc ctattactat aattgatact atagctaata
    20821 tatatatacc tattcctacc tttggtattt tttcttgttt tttagatata ttgattagat
    20881 ttattacact acttctacat attgttataa aaccttttac agccattatt ataaatatag
    20941 aaataaagat taaagtagca tatagtatag cttctatact aagtccatta gataccttta
    21001 tattaaatcc agataacttt attatcacta cttgaaaaaa tctagatgtt attatcccta
    21061 taattattcc tgttatacaa gaacttattc ctataagcat attttctaca aaatatattt
    21121 ttcctatagt atataaatct aatcccataa aagacaatat tccaatttct ttagacctat
    21181 tcttaaaaaa tatatttgtt gcataccata taaagaaaaa taaaaatact gatagtatca
    21241 ttattacagc tactaacact gatagtgtaa attttttatt ttcatcttgt aacacattta
    21301 tagcatcacc atatcttaat aattcaaaat tagttagcac aactactgaa aaaaccatag
    21361 atataaaaaa tgctagataa gttcttatgt tactcttaaa attattataa gcaattccaa
    21421 gtatactcac ttacatctca cctcccatag aggctagcat atccataatt tttccataaa
    21481 attcttttct actatttcct ttgtttaatt tacactttat atttccatca tttatcatat
    21541 atacttcatt tgaataactt gctgttagag ggtcatgtgt aatcattata atagtagcgt
    21601 tattttctct gtttattttt tctaatgatt ctaaaagttc atatgctgat ttagagtcta
    21661 aagcaccagt tggctcatca gcaaatatga ctgttggatt tgtaattaat gacctagctg
    21721 ctgcgcctct ttgtttttgt cctcctgata actgatatgg atatttatct aaatgatttt
    21781 ctaatccaaa ttttttagct atagaaaata ccttagcttc tatctcctta cttttctttt
    21841 ttcctaatgc tagaggaagt gctatattgt ccattagttt catattgtct aatagattat
    21901 agtcttgaaa tataaaccct attttttctc ttcttaattt tgatagttca ttatttttta
    21961 cttttgatat attaattcca tctagtatta tttctcctga agtttgtttg tcaagtgtag
    22021 acattaaatt tagcaatgtt gtctttcctg caccagatgg acccattatt gatataaaat
    22081 caccttcatt gactgtaaga gatatatttt ttaacacatt tgttttaaat ccttttattc
    22141 cataatcttt tgatatattt tttattttta atatttcttt cataataata gcctccagtt
    22201 gctaattttt taatatatat ttattttaaa ggttttatat aaataaatcc ttaagtaaat
    22261 attacatttt aactgttagc attacacttt tgtaacatat ggaagactat tataattata
    22321 gtagaaatat cttaaaataa aagcatgatt tacttctttg tataaacaaa gaaaagaagc
    22381 tcctaagaag cctctaatct atacaattat tcttctctat aaaaaaccaa aatacacatt
    22441 gattgtggca aatacagata ctataaacaa gtgatattac tactatatat taaaacaatt
    22501 attcctgaag ataattcaat aagactatca agcaataagc taagcatcca aaaagactta
    22561 ataccattaa tgtataatta tacccaatat taatgctcaa aaaaccagca acagttggaa
    22621 taatcagaga tgaacctccc ataaatatac ttaaagctat taattggcta ctacttctaa
    22681 gttttttagg agaaacttca aatattaatc tttttgaagt aattaaaatt aaaggagtag
    22741 aaaacacttg aaaaacacac agtataataa tgatatttga atcatttgtt aaagcaaata
    22801 atagaaactg aactgttatc ataatagcac ttaattttaa taagtttaaa ctgctatatt
    22861 tttttaataa ataagaacca gccagatatg ttggtatctc taacaatgac tgtaaagacc
    22921 actttaaaga tatctgagaa tttgtagcat ttaaagctat cattttatct attacagtac
    22981 agttatttgc taccaccatt gagtataata agaataaaat acatactagt aagatatatt
    23041 ttttatcttt taataattca ataatatctt tattagttac atttattttc ttattaatct
    23101 tttcaatatc aggtaataat agtatattta taataagtaa tactacaatt aaaccaatcg
    23161 ctacagataa tccaaaatat gagaatctaa gaatcaagta agatgctacc atacttccaa
    23221 tagcccatcc aatcgaccca aaagtcttaa taaatgacaa ataattatta atattatctc
    23281 cacaacctat tatccatgta tcatataaac tacagcaagt atttaataat cctcctgata
    23341 aagcaacaag taataagtat attataaaag ttgcagattc agtagaaaac ataataactg
    23401 atgcaattcc ataaactgat aaactaatta aaacaatttt tttcattgtt tgatacttat
    23461 cagctaatac tccaaataat aattgaaaca atatattggt tattgcatag ctcgataata
    23521 taattcctct ttcaaacgct gagtaaccta attttgataa gaaaggtgtg aattttgttg
    23581 aagcaaaggc aaaaataata tatgagaaaa aatagaatat gataaattta aatttaatcg
    23641 ctttattaat cataatcaat caaaattgat aactttaata ccactatttc cttcctgatt
    23701 taagtttgaa agatgatatt ttaccgtatt aggattctct acaataacta aaggaatata
    23761 taaagtattt tcaagtaact tattatcaat ttctactaac ttttccccca tattaacttc
    23821 ttgaccttgt ttaacttcta atttaaagtt ttcttttttt gttgttgcac tatccaatcc
    23881 aatatgaata agaatttgaa catcattttg caatttaatt cctatagcat ggttagtttg
    23941 agcaataaaa cttattactc ctttagtcgg tgatttaaga atattgtcct ttgctatcat
    24001 agcaaatcca tctcccatta ccttagttga aaatacttta tcaggaattt ctccaagatt
    24061 aattattttt ccatcaatgt atgaattaat tgtaattgct tctttttttc ttttaaagaa
    24121 cattatagac actcctctac ataattaact ttattctaat tatcattaca aataacgata
    24181 ttaagcatac tgcaattgag gaaaaaagag ccttatagct ctttccccat tgtagttctt
    24241 taatactgct tatgatttgt ttaattccaa caaatttata aatataggta aacatgataa
    24301 caatagttat tgtgtaaatt tggaatatct gccctaataa gactaaatag aaagcaatca
    24361 tgttttcttt tatctcttta ttctttttta tattgtaaat aacatatgca ctgtatactg
    24421 cactaaagtt agagattaaa tttaaacttg cattaacatc attgtttaaa agttgtgaaa
    24481 atgaaatatt tgtaaataat gatgtcaatt ctaaatacac tatatataaa acaggtaata
    24541 ttagaaaaca aaccataacc actgaaagaa atatattttc atcttttaat actgctgtga
    24601 tattttttat tttatttgtt atcatgtttt tgttctcctt atttaaaagt tggccagaaa
    24661 tccttattag ccacaatcat ttcatctaag atttcttttg ctacttttgc acttggaaca
    24721 gttttactca tagtaaacga ctgccataat ttttgataac ttttttctat ccatgcttct
    24781 acagctaatt tttcagaagc aacttgttgt tccattaaac ctttttggaa agttggaatt
    24841 ttacctatag acataggttc aaccatatct tttccaacaa ggcaaggaat ttcaaccatt
    24901 gcatcatctg caaaattttc aatagctcca ttattaggaa caatcagtaa aaatctttcc
    24961 tgagtattaa atgctaatgc acaagctaat tcaacaataa attgagaatg ttcacttgca
    25021 tcaaaccatg tatctcttgc tgtgccattt tttataattc tttcacattc ttcgaatgta
    25081 tccttttctc ttctatccat aatttcattt gctcttgtat aatttggatt agcatgttca
    25141 acagtttcat cagccattaa ataatatttt aaataagtat taggtaatgt agtcggttct
    25201 atttccaata aatcctttgc tgctctcata gtttctaacc aactagattc tttgtgttga
    25261 ccttgaggtg taaattcctc atatcctttt ttagcacaat attcctgtaa tttaggcatt
    25321 aaatcatttc cttctttgtc cttaatactt gtccaccacc cgaaatgatt caatccataa
    25381 tatctaacat caaagtcttt acgagaattt aaacctaaaa ctctagcaaa tatttcctct
    25441 aaacatactg gcatatcaca aatattaata attcttgaat ttggtcttaa tacacgacat
    25501 gcttctgcaa ctatagctgc tggatttgaa taattaagca tccaagcatt tggagaatat
    25561 ttttccatat aatcaatcat ttcgattatt ggacctattg ttcttaatcc ataggcaatt
    25621 ccacctgccc cacaagtttc ttgaccaaca accccatatt ttagtggaat tttttcatct
    25681 tgttcacgta aagcatataa accaacacga atttgtgcca ttacaaaatc aatatcagta
    25741 aatgcttctt ctggatttgt tgtataacta aatttaattt ctggattttt ctctctaaca
    25801 attattgcac atgcttcagc aacttttctt tgtctctcat cattattatc atataattta
    25861 attgattcaa taggaaattt agcaacactt tcaattaaca ttgttacaat tccagcagta
    25921 taagtactac ccccaccagc aattagtatc ctctgtcttt ttctttccat ctttccttct
    25981 cctttataat aaattttcaa attcttctct tacacttggt actgaaagcc caataataat
    26041 ctgaatagct tttccattat gcactaaacc atgtgcacct actgccttaa aatcttcttc
    26101 tttagaaata attgagtcat ctttcaaggt taatctcaac ctcgtagcac agtttgtaac
    26161 atctacaaca ttttctgctc caccaactaa ttttatgtat tcagatgctt gttgagaggc
    26221 tttactcaat ttatttcctt tttcatcttt agtttctaag tattcatttt tagtatatag
    26281 ttttgtttct tcactatctt cctctctacc aggagttttc atatcaaact tcttaattaa
    26341 gaaagtaaat acaaagaacc agataaatga aaatataatc cctacaacaa cttgaacaac
    26401 atataccttc cagtgataca ttccaagagg aagccaattt aatacaaccc agttaataat
    26461 tcctccacca aaatcaccaa caactcctag ggcaaacgaa atcgtttgca agcatgcatc
    26521 taaaaatgca tgtactagga ataaaagtgg tgctacaaat aaaaatgtaa attctaacgg
    26581 ctcagtaatt ccagttaata ctgcagtaag agtagcagga atcattaaac ctaatacttt
    26641 tttctttttt tctggctttg cagttacata gaaagcacca aatacaccta atgaaccaaa
    26701 caccttcgat aatccggata atgaaaatcc gattggatac atttccttta gagtcttagc
    26761 tgaagtttga aaatcctgaa tatgagtagc ccaatatact gatgtaccac ctggaacaac
    26821 aacactatca taacaaattg gtgcatatac aaaatgatgt aatccagttg gtattaaaat
    26881 cttttgtaag aatgcataac accaaactcc tatatttcca ctatttataa aaaacgtttg
    26941 caaatgtcta ataacatttt gaatatgagg ccaaataaaa caagttaata atgcaactgg
    27001 tatcataaca aagaaacaaa ttgcaactac aagtgatgag cctctaaata atccaataaa
    27061 atctggcagt tctttatcat aaaatctatt atgaatataa atgacaatac ctgatattaa
    27121 caaagcacca accataccag tatctaatgt tttaatacca gcaatgctta caagtccact
    27181 tccagcactt atttcagctg cgaaatcaac tccaaagctt tttccccaaa aacttaacat
    27241 agaacctaca aaataattaa aagtcaaata cgttgctaaa gcctccatac aagctcttgc
    27301 ttgttgcttt tttgcaagtg ctattggtaa agaaatagca aataataatg gcaattgatt
    27361 aaataccatc caagctccac tagatattac accccaaaat tggtaccaaa tattttctgg
    27421 tgtagcaagt gaacccataa ttgactgatt ttgaaataca attgagaatc caaccattat
    27481 cccagcaaaa gcaaataata gtgttggtgt aaacattgcc cctccaaaac gctgtatttt
    27541 cttcatcata taaattactc ccctcctcat atttttagtt tatctttggc cttagatatc
    27601 tattatttta acaggttaat aaatatatac aatctttagg gtacattcgg agcttattca
    27661 cagtcaaata agtttttgca catttttatg ttcaaattct cataaaaaaa aagaatgact
    27721 acaatttgca atcaatccct tctgtaatca ttctatgcct tttataaata ctatatttaa
    27781 taaataataa ctcaatcaat ataaaatata acattgtcaa tttataacta gggtgcattt
    27841 gtaaaaatga gatattagtc gctgaaatat aaattgattc atcacttaaa tcagtcaatg
    27901 tattattttt aaactctgta attgaaatta ttttagttcc tattaatttt aatcttctag
    27961 caatattaag tgtattctca ttctcaccac ttagggatat aataatcata acatcatttt
    28021 tactgacaat attgtaaaaa gaatcatcaa atgttcttcc ctcaaaatca tatattattt
    28081 cttgacatga taagaacatt ctctttatct gttttgcaac cacattttga atatcacctg
    28141 aaccataagc gtatattgtt cttgattcat aaagaagttt acacaatgca tcataatctt
    28201 tatttttttg atcttcaaca tacttaatta ttgaattaca tgcaatatca aatgactgat
    28261 tttctatgac atgaaccttt tctgattccc agcttaataa tactttaaac tcactgaaac
    28321 cttttaaatc taatttttta acaaatcttg taatagttgc acgagacaca ttacatttca
    28381 tagcaagttc atttattgac atcttactac aatgtttttt atttgcagtt atatatttcc
    28441 atattaataa atctgtatca ttcaatttat tataatttaa aaaaatcatt tcttctaatc
    28501 tcataaacta ttaccccctt taattaaaaa tcgtcataaa tattatacca atattcaaca
    28561 ttaaattaca gcgtattctt atatttacta tttagcccat aaaattgact ataaaaaata
    28621 ctgctataat tgatgtttaa aaaaatgtag ttttaatttt attcttttat ctaataatta
    28681 atattttcaa gttctagtgc ttttcttata caattatcat ctttaaaatc agcagtcctt
    28741 ttacaatctt ttactttaaa ttctggaata gttttaaatt cctcatcaca tattccattc
    28801 ttatttaaat acatacaact tgccattcta actattagac cactattttt taaattaaac
    28861 aatacagggt ctatacaccc tccatctccg ccagtagttt caccaactaa agtcgcaaat
    28921 ttattttctt tacaaaacat tgcaaatgac tctgatgatg aatatatttt tctatcaaca
    28981 agtaagtata tattaccctt aaattttgaa tcatctgtag attttatagt ataggaagta
    29041 tcttcaaaat cattaaaatc ttttataatt tctttaggtg cattttcctt tacacttgct
    29101 ggtaaatttt ctacaggatt taattttata tttcttgcat ttgtatattt ttttactatt
    29161 tcattattat ttctataaat tctataacca tttattttga catcattttt tatgagttta
    29221 gatacgattc cctgccaata cctatcactt ccacctaaat tacctcttat atcaataatt
    29281 aaagctttat gtttttctaa agtgttaata taatctccaa ttatttttaa atcattattt
    29341 atagagccat tctttgatga cattgatggt aaatacatat atccaatctg acccttaata
    29401 acatccttta aaattaattc tttttttaca aaaatatcat ctggcatttt tattttaaga
    29461 ttcatagagt catatctatc cacaactttt ttatcattaa gaaaatcata ccaatcatta
    29521 ttagagtatg atttcttaaa aagttcatat cttttcttat tatctattac ttctgtgtgt
    29581 ttattattta aatcagataa tatagatgac agttcttcta taaattcttc atcattttca
    29641 gtgtttttta ttcgttttgt atattcatcc ttatttgcta accaatcaat attattaagc
    29701 ctcttattta cacctagata tggatatcct gtctttacaa cattatacac ataattaaag
    29761 tcatccacct tttcctcttc agacaactga ttcttttgag aataagtaga attacctaat
    29821 aatattataa atgctaaaat aattactaaa aataatactt tctttttcat gtaattctca
    29881 tccactttca gattttatat tttaatacat tgtatcatta ttttattatc acctaaacag
    29941 ttaaaagaaa ttcttgaaga tatattccac tattattctc tttaaaaatt tttatttgta
    30001 ttttcaaaat tatttcatga aagttataaa ataacaatta tattcaaata tctattttac
    30061 tgctatatcc tgaaagtaaa ttcttatcag tgatatacta aaaaagatat gctaaaaaat
    30121 ttatccatta taatgactta aatttagata ctttactgat ttttatttat tagttgagaa
    30181 agatattgat aattaaaaat attgataact atagaaatga ttatttttta tagaaatttt
    30241 aaggatataa actaattata cttaagtcta tatccttaat ttatcatgat tatgagaatt
    30301 tttacaaata cttatctttg tccgttttag aataaaaaca agaacatatc ctgttatttt
    30361 attcaaacat ccaagtttaa ttactacaca attacttatt agaaattgta tctacttcat
    30421 atatatatct gttaagtata gcttctagca tttcttgtct tccagactta ttctttataa
    30481 ctggcatttg cagtgcataa gattctaact ctttaaatcc aaccttacct tctactatat
    30541 ccttacctat accttcacta aaacttgcat atctttcttt agtaaagttt tcaaatacct
    30601 catcttctaa taatttatga gctattaata atccctttgc aaatgtatcc attcctgcaa
    30661 tataagctag gaataagtct tctacctcaa aagatgctct tcttacttta gagtcaaaat
    30721 taaaccctcc tggtgctatt ccaccttgct ttaacacttc atacatagca agtgttgcat
    30781 catatatatt tgttggaaat tggtctgtat cccaacctaa taataggtct ccttgatttg
    30841 catctatact acctaaaaca ttgtttattc ttgctatatt taattcatgt tggaaagtat
    30901 gtcctgcaag tgttgcatgg tttgcttcta tattcatttt gaagtattta tccagattat
    30961 actttcttaa aaatcctaaa acagtagcag tatcaaaatc gtattgatgt ttagtaggct
    31021 cttttggctt aggctctatt aagaattgtc cagtgaatcc tatttcctta gcatagtcta
    31081 cagccatttg taagaatctt gcaaagttat ccatttcaag ttctgtatta gtgttaagta
    31141 aagtttcata accttctctt ccaccccaga atacaaaatt ttctcctcct aagtacttag
    31201 ttatttccat agctttttta acctgagctg ctgcatatgc atatacatct gcattacatg
    31261 ttgtagatgc accatgaaca aatcttggat ttccaaacat attggcagtt ccccataata
    31321 actttatacc tgtcttttcc atattaactt ttatatactc aactatttca tctaatatct
    31381 tatttgtctc ttctaaatct cttccttctg gtgctatatc tctgtcatga aaacagaaat
    31441 actcaattcc catcttagac ataaattcaa atcctgcatc aactttaatc tttgctatct
    31501 caattgggtc tgttatatta ttccaaggtc tctctactgt gcctactcca aatgggtcat
    31561 taccctctcc acataaagta tgccaatagc tcattgcaaa tcttaagtgt tctttcatag
    31621 tcttattacc taccacttgt tcaggattgt agtatctaaa tgctaattca ttgtcagatt
    31681 ttactccttc aaattttatc tgtcctattc ctttaaatat ttcactcatt tcatgtcctc
    31741 ctaatatttt acacatataa tatatgtagt atgttttctt aatttaaaac tattttctat
    31801 ctttattttt ctttttaagc taatttaatt atttattttt gcattaacta cttcatctaa
    31861 taacttaaag tcatctttca aagatttgta tattctttta tacaatctat gatatatatt
    31921 gtatgtatct acattttcac ttattggttc taatttagtt gaagttttta ttatagcatc
    31981 acaagctttt tgtatatttt catatattcc agctcctact aatgcaagaa ttgcaactcc
    32041 aagtgctggt ccttcacttg aatttatagt atatacatct tgattaaaca tatctgcttg
    32101 catctgtctc catactttac tttttccacc tccacctgag gctcttactt cattaacgtc
    32161 tatattaaga ttctctatta tatccataca gtctttaaga ctatatgaaa caccttccat
    32221 tattgacctt gcaatttctt ttttagaatg gattggagat aatccaaaga acacacctct
    32281 tgcataaggg tcaagatgag gagttctttc tcccatcata tatggtaagt aaagcaatcc
    32341 attacatcct gttggtactt tacttacttg attatttata atctcatata catcttcacc
    32401 taaagaattt gaaacttcca cttcactttg acagaaatta tctttaaacc attttaatga
    32461 caagccagct ccttgagtaa ctcccataac atgccatgta tttggtattg catgacagaa
    32521 agtatgaact ctaccttctt tatcaatttt tggctctttt gtataagcaa atactacacc
    32581 tgatgtacct atagtagatg aaactactcc atctttaact attccatttc ctatagctcc
    32641 tgctgcttgg tctccagctc ctcctaccac tattgttcct tctttaagcc ctgtcaaact
    32701 tgatacatct ctagtcacat aacctgtaat ctcttgtgat tcataaactt tacctaaaag
    32761 atttttatct atatttaact tttctagtac ttcatcgctc caatctcttt ttcttatatc
    32821 gagcaactgc ataccacttg catctgatac ctctgtagca tattcacctg tcaatttgta
    32881 tcttatataa tcttttggaa gaagtatttt attagtattt ttatatatat ctggttcatt
    32941 gtttctaacc cataatatct ttgatgctgt aaatcctgta agtgctggat tagcagttat
    33001 ttcaatcagt ctttcttcac ctactaaatc agttatctcc tcacactctt ttactgttcg
    33061 ttggtcacac catattatag agtttctcaa tgttttacct tcattgtcca gcataactag
    33121 accatgcatc tgccctgata atccaattcc ttttatacat tcactgctta tatttgaact
    33181 ttgaactact tctcttatag attcgactac agctttccac caatcatttg catcctgctc
    33241 tgcccaacct gatttctctt gtataagagg atattcatat gtacaacttt ttatagtatt
    33301 tcctagttta tcaaataaaa ctgttttcgt acctgatgta ccaatatcca cacctaatac
    33361 atactccaac ttcatccctc cttgaatgcc acttcataac tatcgttttc ctatcctaat
    33421 ttttttatat tttaggtata ttttacttgc tttatttttg ttagtatatt aaactaactt
    33481 atgaactaat aataaaatat ttaattatct ttgtcaatgc aaaataacct tttatttttg
    33541 tgtaaaaagt attacaatat tattttaagg aggaatatca aattggttac tgataaatac
    33601 actattcgag aaatgaatga aagattggta cttgaacaaa ttataaaaaa tggtcctatt
    33661 tctagggcaa gtatagcttc tactatagga ttgaataaag caactatatc cgctattacc
    33721 aaaaaactta ttgatgaatc tctagttcat gaaataggaa ttggaaatag tactcatagt
    33781 ggcggaagaa aacccatatt attagtattt aataaatgtg cagggatttc tttaagtatg
    33841 gacattggat acgactatat attttcttct ctatcttact tagatggaac tattataaat
    33901 tctaagaaat taacagatat acaagtaagt aaagacaatg ttatacaatt gatagatgaa
    33961 attataaata gttataacat atccaaaata gacactcctt ataaggtaat tggtcttact
    34021 ttggctatac atgggattac ttgtgaaaat aaagtattgt ttactccata ttacaatctt
    34081 aatgagattg acttatatag catccttagc aaaaagtatg actttcctat tcatatagaa
    34141 aatgaagcaa acttaacagc tttagctgag aatacttttt caactgtaca taactcacta
    34201 cttagtctca gtattcacag tggatttggt tcaggcatta taataaataa taaattatat
    34261 agtggcagaa atggtatgag tggagaaatt ggtcacacta tcatcatgcc taacggtaaa
    34321 ctatgtcctt gtggaaatcg tggctgttta gaacagtatt gttcagaaaa aaaggtattt
    34381 gaacagcttt cttctttaga aaatattcct aaaatagatt ctgatatagt aaagcaacta
    34441 tattatgaag ataaccataa tgccaaaaaa gttattcatg agttttgtag ttacttaaca
    34501 atagctataa ataatgctat tacaacttat gctcctgaaa taatatattt aaatagccaa
    34561 ataattagtg atatccctga gatattacag attacaaaag atatgttagt tagctctttt
    34621 aacaaaggaa taaatataga aatttcatca ttagggtctg aggcatctct atatggtggc
    34681 tctgctgtaa atatcaagag ctttttgaat atacaaaatt taactttaat taatgaaata
    34741 taagggttat gactatatac agccataacc ctttaaatta tacattctaa aattagattt
    34801 attatatagt ttatgcaaga ttagctatat tttttaaaaa ttgtatatca attaagtatt
    34861 aacataagta tttcgtttta aatattaata taatcttcct actcatcatc agataataaa
    34921 tttgcatttt gttcaaccat agaaatatta tctttaccta ttttctctaa ttttgctgcc
    34981 aattcctttg tatctaaaaa agctgattca ataaccatac ctaaatttag ccctgaaata
    35041 attttaattc gactgtcatt attggctact aataaagcag cattgcatgg agttccacct
    35101 agtaaatctg ccattataat tatttctgaa ctttccttgt acacttctaa agcttttttt
    35161 aatttttcta ttgttccttc tattccatca tcttgtttca tatttacagt aggataatct
    35221 atagaatccc ctattatcat ttttgcagaa tttaagactt cttcagccat attgccatga
    35281 ctcatcaaaa taatactatt caatttaata cacctcttta aatctataag atgtctacaa
    35341 gataagtttt cttatcatca ggcgtcatta tagttgtaat ttcaattcct tcatctaaaa
    35401 gtcttttaaa tgcttctttc tcttcttcag taacactgat attaggtctt agaactgttg
    35461 tatcttttct acttgacata tttcctacat ttatattatg tattttaaat cctgcctcta
    35521 caaatggaat aaggtccaca ggagacttaa caattaataa tacattttgt ccttcatact
    35581 ttcctgcagt aatatttttt atagcagtct cttctgtaat tatagatgac gctatacctg
    35641 caggtgtagc cattcttaaa acttgttttt gaacagaatt gttagctact gcatcattta
    35701 ctaccattaa tcttgtaaca cccaatttat tactccacat agttgcaact tgaccatgga
    35761 ttaaacggtc atctatacga atatttttaa tacctttcat ttccatatct aatatcatcc
    35821 tttccttatt ttaaaatacc taatgcatat aaaattattg aaacaaccat tactcctaaa
    35881 attaagtata taggttttat attcttttta agagcccaat aaacaatcac aactaaaatt
    35941 gcaggaacta acccaggcat aatttgatct aatatttctt gacctttcat tgtaaaatca
    36001 ccttgttgaa agttcaaagc aacattagct tttacaactg aaggtattaa tgcacctaca
    36061 accattaaac ctaaaataga tgtactctca gttaaaatct ttaaactttt ttcaattgaa
    36121 gatattagct tagtacctga tgtataacca gcattaaata gtggtatact taataatttc
    36181 aatgctacac tcactacaat ccacagtaag attccaaatg gacttccatc tatcgccata
    36241 ttagctgcta tagctccaaa aattgtccac ggaataacga caaataaact atctcctaaa
    36301 cctgctactg gtcccatcaa gcctgtttta attgaagcaa cagcctcttc agtctcttca
    36361 cttgataact cctccattgc tacattaata cccaaaatat aaggggcaac ccaaggatta
    36421 gtgttaaaaa attgtaaatg atttaataca gcactttgta acttttctgg attatctttg
    36481 tatactactt ttaaaaaagg tagtactgca taacagtatg ccaaggcctg catcttctca
    36541 taatttgaag aaacagaact agtaaaaaac cagcgccata agacactttt tttcaccttt
    36601 tcatttgatt tatttaatga taccttatca ctcatcttcg tccatacctc ctactacagt
    36661 atattgttgt tcttgatttt ccaaattctt tttgtaaatt ataagtgcaa ttgctccacc
    36721 aattaaagct acacctaata atggtacttt catatatact gctaaaacaa aaccaattac
    36781 taagtaacta aaatactcct tagcaggaag atatctaagt aataatccta tccctactgc
    36841 tggaagtagt cctccagcta ctgttaaacc acctgttaac cattcaggtg tatatttcaa
    36901 aatggtatta attaaagaag gtccaaatat tacagataga gcaactggaa tacctgttgt
    36961 agctgctgtt aatagtactc ctaacatttg catataggtt atatttttat aatttccttt
    37021 tttagctcca tcttctgctt tatgaactag ccatatacca atagtatttc taagaacatc
    37081 taattgtacc atcaataaag caactggaat acctatagag attcctacag atgcttcttg
    37141 cttagtcgta atagttataa atgtggctac tatacttgct gtttgataat caggtattga
    37201 tgctccacca aagttactaa tacctaatga taatagctgt aatgtacctc caatatataa
    37261 ccctgtattt atatctccta agataagacc agtaataaaa cctgctgtta ctggttgata
    37321 tgttccaaac attgttgaat ttttttcata gtttataaaa aatccatata gtacgattaa
    37381 taataattgc cataattgtg gctccattat gatttcacct ctcccaaaat attttttagt
    37441 tctttaaaat tataactgga atcttgcttt aggaaaatag gaatttcttc cagtgggcat
    37501 tcaacttcat aagttttccc accttcataa ctaactccac taaatatatt ttcccatgta
    37561 tgtccttttg gtaaatatac ttttctactt ctatctttat aattcattat tggagctact
    37621 aaaatttcat ctccaagcat atatgtatta tccacctccc aagttttatc atcttcagga
    37681 aattcataaa ataaagttct cataactggt gttccatctt catgcgcttc tttcatcagt
    37741 ttttttaaat aagtttttaa gctctctcta atttttatga attttgtaag aattacttca
    37801 acttcttcac cataagacca tatttcatta ggagctccag ttaccattga gcctccacct
    37861 ttatttgata atggtttact atgaggcaat ctatctccat gcattctcaa aattggtgaa
    37921 aaagtagcat attggaacca tcttaccata agttctctaa attctgggtc tttaggattt
    37981 cctccatgga aacctccaat atcagtagtc caccatggta tacctgccag tcccatattt
    38041 aaccctgtat ttacttgatt attaaaagct tcaaaactag aatcaatgtc accagaccat
    38101 actaaagctc catacttttg agctcctgcc caagctcctc ttacaagagt tacaacagac
    38161 tctatgtcat tatgtaaacc atcataaatc atttttaaat aatcaatagg ataaatatta
    38221 ccacaactta aaacatttcc ttttttatat ctatagttat caaaatcata cacagaatag
    38281 ccaggttcag ctacatctaa ccaataatag tcaatcccaa gttgtttata atttttatct
    38341 attctatccc aaacatattc tcttgcattt tcatttgtca tatctacaaa gactgtattt
    38401 ccttgaattt gcattgtcat tctaacacca cgattaacat tgactaaata gccattttct
    38461 aaataatcat tgtagttttc tgcatcactt tgaactgtag gccatacaga tactattggt
    38521 tctactgaat actcttcttt caatttttta actaattctt taggattttt ccaataatct
    38581 aagtcaaatt tatattcacc ttgcttaggc caatgaaaat agtcaattgc aattgatgaa
    38641 agcttaattc ctcttttaga atattccttc acaacatcta aaacttcttc tgaagttcta
    38701 tatcttagtt tactttgcca tagtcctaaa aggttttcag gcatcatagg aacagttcca
    38761 gtaacttgag agtaattttt atttaactct tttgggcttt ctccacaagt aatccaataa
    38821 tctataaaat ttgtagaaaa catcttccat tctgtcatat ttttagcaaa agatactttt
    38881 ccaattcccg gattattcca taaaagtcca taacctagac tagaaatata aaaaggaact
    38941 gatatttgag aatttctttg ggctaactcc aaaacagtat tctttaaatc taaaaattta
    39001 tgttgatatt gtcccattcc aaaaatcttt tcagaaggct cagattcaaa tctagtagtt
    39061 acttcaaatt ctccactata gcttggtcga tattctcttg attttaactt tagagtagag
    39121 ttaaagtctt tggtaatctc aattgtccct acatcttctc caccatcatc atgttttaca
    39181 gctcttaatc gaatatattc tttcaataat atttcatttt tatcattata aaaagtaatt
    39241 ctatctctat ggtctaagac agcttttatc tttccatttt taatgattgc acttccatct
    39301 tcatttttat taattgtaat atcatcttta tttaacttag gtttttcgtt aagagcatag
    39361 ttttcatcaa caaaattttg gtctacaaac gacctaatac gtaaagagtt ttttccccat
    39421 gcttctattc gcaatagttc attgtcaaat cttttttcaa tatagtcttc agatattttt
    39481 atcacggcta cctcctaaat caatggtata atattctatc tttgtgtaac ttaagttaaa
    39541 taatgtcgtt tagtatcgtt atttataaat taggttttat atataattca tttgtacatt
    39601 aaactaactt accaataata tactttattt gactttgttt gtcaatcgct ttccggattt
    39661 tagtaaaatt ttctaatata ttgctggaaa gttgttctta atatctttta tttatacttt
    39721 taatatctgt gatgatacct atatacatct agttttttta aaacacatac aggaataaca
    39781 tttgcctatt atgtagataa tatcggactt gaaaatatgt atagtgacct tataaataca
    39841 gataataata tattagatat tgttcaaaac aatggatttt ataattataa ataatttatg
    39901 aaattattta agaaaatata caattgtata ccaagtcaaa aacgacaaca aataaataaa
    39961 actaaaaaag atgttgtctc aaaatataga taaatttatt tttcattgct aaaatgatta
    40021 aaatatattt gatttaatat acttgattta atataaaaaa agagtgtctc ataaactaaa
    40081 aagttcactt ttagacactc ctttatatat attatctact tcttaattca tttattacct
    40141 ttctacattt tctttcagct agtggataca tctttataag tactaattac tccacttaaa
    40201 aatggttcct gtactgtcca tcagtcatat ttttctgcca aatataatgg tgtttcataa
    40261 tgagacaata aatatttata tctctactta tcttctctaa gctcgtcaaa tccaactata
    40321 ggtatctcta aattatattc tttaagtagc ttttctagct cttctataaa aatacctttc
    40381 ccatccacca tttgtatatc ctttatttta tccatcaatt cattgcaacc acttaactca
    40441 ccaaaccaac gtttagaact acatgtctta ttataaccac aacttggact gccatctatt
    40501 gcaatgatac tttttatatc ataatcattt tttaaatatt catcaaactg ccttacatga
    40561 ggtattaaca tttgcctaca ttgttctcta aaaaacaaat tgtcaaactg ttcttttaca
    40621 tgtccccacc tatttattcc atacataatc atttctgggc atggtagttg aattattcca
    40681 taccctttat ttattaaatt tatcgctata ttttgtgctc ccttaaattc tgacaatccc
    40741 tccactttag aattacaatt taatatacaa tgacatacta ctacaatctc tctatttctt
    40801 ttcataataa tctccttagt tattcttaat tttaatgata ctacatattt tgataattat
    40861 attatttatt tgttctatat ttccaatatt ctatatagaa atatacaatt agtaatcttt
    40921 tataatctat actatgataa atgtatatat ttttttagga ggtattataa ttggatacta
    40981 aaaaagtcac attttcttca atgtgcatag ttattaatat tgtcttaggt atggttatat
    41041 ctatgataaa tataccatta ttatttttag atacagttgg tactgtactt ggggctgtcg
    41101 tattaggtcc tttttggggt gctcttattg gtggatgtac aaacttagtt ttaggtgtta
    41161 tatcaggtcc tacaaatata ccttttgccc ttgtaaatat tgtccttggt cttattgttg
    41221 gatatatttc taagaaaaaa ggttttggtt ataaagaagc tattattaca ggagtaattt
    41281 tatctattgt ttgtccttta attggtactc ctatttcagt tttattgttt ggtggtttaa
    41341 gtggaagtgg tgctgattta ttggttggtt ttttagttca gtctggtcag aagatattta
    41401 ctgctgcgtt ctttccaagg attcttagta atatagtaga caaacctttg tcttgtatta
    41461 tggtggtata ttttataagt aaaatgccta aaggttttat aaaacaatat agtaaaaata
    41521 cttctagttc atattaataa atcatttatt atgtaaggtt tattactctt taaaatgcta
    41581 tatactcatt tttatataac atttttatta ataatttaat tagatagtat ttgtattact
    41641 ttaattaaac gtaacctctt gatataaatt tgagctataa atctatatca agaggtgcta
    41701 ttttattttt aatataatta atattctatt acgcaaaaaa tgcatatatt tcattatttt
    41761 atggaaaata ttacttcatt taactctata tcaaactcat taagtaaaaa tctaattata
    41821 tttaatttag cctctgtatt taaatttgtt tctaaatata tattttctga tattttaata
    41881 ccttttctta atttatatgc atctctagac ttaatattat ctataaaatc tcttttataa
    41941 gttttgtcta caatactgtt aaaccttaca gaatccaaat catataaagt aagagcaact
    42001 tgttcataaa attctgtcca atttttagcc ttatatgact ctcctaatat actaaatgat
    42061 actatacttt catttgtaaa attaacatca tcatcctcta acgtaaatat attttcactg
    42121 ttacttggag gttcatatgt aacacttgga tatttccaaa tttctacagc tctatctagt
    42181 aatatcttag ttctattttt tatttcttct tcattccatt tatctataga tgaaatatat
    42241 ttatttagat aaagcctact atctttaaat ccatcttcca tttctttctt ttcttcaaat
    42301 gttttattac ttagttttga attatatcct gtcaaagtta aatttccaat tgtatgtaaa
    42361 tatttatcat gtatctcctt atagttatct cctagtgatt ccttccattt atttgttaat
    42421 gtctgtggca ttatatgctc tatatttagc atattattat tgattaaatt ttctaaatca
    42481 acaatttctt tattactata attctctaac ctctcaagta tatataactt attctttgac
    42541 ttagtattat atatatcttt agtttcaaaa gcatttgaaa attcactgtc agtaggaaat
    42601 ctttgagatg atttcttatt tataaaaata tatcttaata tattagaata gttttcttta
    42661 taatcactaa attttttaat ttcccttcct aagttcataa atactttatt cagtgcattc
    42721 ggaggtacat cacatactat tcttcttaat ataaaacatt ctactaaatt aagggattct
    42781 acaagtactt ttttatttat tataccttca ttataatcat caaataattc taatataaac
    42841 ggatatgata caaatatttc aagtttgttt atccttttca aaactttgtt tacatcatta
    42901 tcatcagtac atgaataaga tatctctcta taatagttag aaaatttaag taaatctttt
    42961 aataaaattt ctatatctat accattatct gatacatacc ttttaaaact aaaatatact
    43021 ttatttttat tcggtatact tctctccttt atagtcaaat agtctcttat aaaactactt
    43081 acgttgctac ttgtattttt ttcaatttta taccaataat tattataaaa ttcctcttgt
    43141 aacttagagc ttctacccat taacacaaag tttcttactc tatcagcttc acttaaatct
    43201 aagccagttg aatttagact ttcaaagatt aattgagggt catcttcacc attttttaac
    43261 tctatttcta ctatagttaa tttctgtata gcatcaaaca aatcatctat tgatatatta
    43321 tcttctttta ttctattata aaaatataaa taatttgaaa ctatattaga atttctatct
    43381 gtattcattt cttcttcaaa tagttcatag tacgcttttc tatcttctgc tattggtttt
    43441 aactttattt ttccatcttt atctcttgag tgcttgttta taagataaca ctccttaatc
    43501 tgttcttctg ttgtaataat tccttttgat tccccaaact cttttattat ttgacacatg
    43561 gcaatcaata atattgacac agtagtcact ctttgttgtc catctattat taaatattct
    43621 tttcccatac tatatataga tacaactgac cctaagaaat gagttctaaa tccagaatct
    43681 attatatcct ctaaatcatc aaacaatctt ttacattgtt ctttcttcca gttataattt
    43741 ctttgatata caggtactac aaaacttttg tttgacccct ctaaataact aagaaattca
    43801 atttctcctg ctttcatatt aactccccct ataagttaaa taaattccat tcataactcc
    43861 atgtatctat atattatatc aaaattttga ctcataaatg tatatgaaag ccttattata
    43921 taccttttta tacctgtttt tattttatta aagtaaatac atgattattc tataaaatat
    43981 acaaatactt aattttaaaa attattattt aatcttcttc atgagtaatt catagttatt
    44041 tatcaattaa aaagagatat tgcataatta ttcaatacct ctctttgtat atttacatta
    44101 tccatatcta gttatctatt tcaacccaat attagactac ctactaataa atttattctc
    44161 tacatcatta acaataattt tgcactaaat aacatcatta gcctatctct gatgcatttt
    44221 ctttaatttt atttatagtt ttaatcaatt tatttctctc ttcaatatga ttttcaaata
    44281 aatcaattat acttccaaca gttctaaatg ggtcttccat caacactttg ttatcctcta
    44341 taaatccatt cttgactaca taatcgacta taagtttaac aaaatgtatt tgcttagtat
    44401 taaagctctt attatttaaa aactctgaaa aagcttcatt tgcagcttct ctatccaatc
    44461 ccactagtct tctcactaat tgacttactg gagtatctcc aaactccttc ttataatcat
    44521 cacaattacc taactgtttt aagagtattt cctccaacgt ttcaacatct tgctttgtta
    44581 tctttttatt atttcttaat ttaaatattg ctaattcatc tttatggcta tttaaataat
    44641 actctacctt ctttttataa ttcttaagat tgtttgcatt atatacagaa tcatttctat
    44701 cttctgctac aatcatatct tcaaaacttg tataatatat cttttgacta gacttttcaa
    44761 gatacttaat aagctctctt aatgatatac gtacttcttc tacctcaaat atatctgaat
    44821 cttcccaaaa attctctgtc attgcttttt caatagtata tttttgttgc tgaatctgtg
    44881 gtatagtccc aagttttgaa agtttttctg ctgtagccat tacatgcctt atacctttac
    44941 ttgcattatt attttgtaag tatgcaagtt gtatattata cataactaca tcaaatcttt
    45001 tagccaattc atcatcacta tatgaagtta tgagtggtga tatatattct cttatctcat
    45061 tttgtgctac tgctccaata ttgctccaaa cattttcatt tttatactta tgtacataac
    45121 ttaaattcat cctaactata taactatcct catttaaagc ttttacagaa gttataagtt
    45181 cttctaacaa ttcttttcta agttctgcat actcaccttc tatatattta atatcttgaa
    45241 gttctttaac catacttacc tttatattaa ataatttttc agtaagtgtt tctgctttat
    45301 ttccctcaaa tcctttagga ttaaatttaa aaaattcaaa attattacaa aaatcaaata
    45361 ttaagaatct ctccttatcc atatcaacac ctaataaatc tggacataat ctagttcctc
    45421 tacctatcat ttgccaaaac ttagtcttac ttctcacttt cttgaaaaaa acaagattta
    45481 gtatttcagg tatgtcaatt cctgtatcaa gcatgtctac tgaaactgct atttgaggta
    45541 atttattctt atcagaaaaa tcatctatta tagaatctac ataatttata ctatagtcaa
    45601 ctgcttttac aaagttccca ccatactttg gatacagctt attaaatctt tcaactattg
    45661 ccctagcatg ctttgtattc tttgcaaaaa ttatagtctt accaatcttt tcttctcctt
    45721 ctattttcaa cccctctgtc attagcttat ttaaaactaa atctattgtg tcagaattaa
    45781 atagccactc atttactgca ttattcccta tttcgtctcc aatactctca tcatcattaa
    45841 atgtattttc atattcttcc ttctcttcat cagaaagctc atcatactta attccatctt
    45901 ccataatctt agtcttaaac tcaatactag tataatctac taaatatcca tcctcgactg
    45961 ccttattata ctcataagca tatgtaggta ctccattttc catgtcaaaa actgaataag
    46021 tatttttatc tatctcatcc tttggtgtag cagtaagacc cattaagtaa gaatcaaaat
    46081 aatcaaagat tgacttatac tttttataaa tacttctatg cgattcatct attataatta
    46141 aatcaaaatg accaggtgta aacaatctct ttccatcctt agacttcgta tcatcaattg
    46201 cattcatcat tgttggatat gtagaaaata tcatcctagc atcttctggg ctgtctttgc
    46261 tatccaataa attacataac gccaagttag gtaatagctt agtaaaactt tttttagctt
    46321 gctttaccaa tgcttttcta tctgctagaa ataatatatt tttaatccaa ttatgtcttg
    46381 aaagtacatc aactatagat atagcaattc ttgtttttcc tgtaccagta gcacatacca
    46441 aaagagtttt gcgttgctta ttttcaaggg cctcacatac agcccgaata gcttcttttt
    46501 gataatatct attggatatt tcatcattta ttgttacaga acttaaagac ttcttactct
    46561 ttcttctatc catcataagt tgtaattctg attttttata aaatccataa acttttctat
    46621 ctgaatagtc atcccaaata tacatatcaa aaccattagt caaaaatatt actggtcttt
    46681 gactatatct cttttccaaa caatctgcat ataatttagc ttgttgttga ccaatttttg
    46741 ggtctttgct cgttcttttc gcctcaacta ctgctaatgg cttaccattt tcaccataaa
    46801 gaacataatc tacatatcct acaccacttt cattaggcat accttgtact tctatttcct
    46861 cccctatatc ttttccaaat tcccaacctg caagctttaa ttctatattt atatatcttt
    46921 ttcttgtctc aaattcgctt acttcgtcta tcttgaaatc atagtttaca gtattaactt
    46981 ttctcttttc agttagtgac tttcttaatt cctcattttc ttttattact tcttcaagct
    47041 ttttatcttt tgaacttaat ctctcgtaaa gatttttaag ttcgtctggt ctcgtccttt
    47101 tctcttctcc atgaagtaat aaatcttcat taaagtcttc tgctgtatat tcatctgaat
    47161 aacaatagtc tatccaacta acaaattgat gcaaattgtt aagtgaaagt attgcttctc
    47221 ctctctctat gttcgcacta gtatgtacag ataaattacc taacttaact atatatttta
    47281 ataaaggtaa catatcatag tctataagtt ctataaaact attattatga atcaacgtac
    47341 tgagattatc ttgataaggc aatactaaat cactatcatt agcatatagc cattttactg
    47401 caagctctaa agctcttctt gttatagttg cacaagtaga tggactaact agtatacttt
    47461 tttctgcttc taagcaagca gtattaaaac tattgaaatt tttcttcttt tgtaaaaaat
    47521 caaaattacc caaggctttt atcccccttt tgtcccttag ttaaaataaa tctctctaaa
    47581 aactatttct tacagctgtt tcttatacta acaaatactt cttcattttc tgtaaacaat
    47641 tcgtacatat cttcaaactg tggtatatca tatccatgag aatcatcatt tctcaatttt
    47701 ctaagtgttt ctataactat agaagaattt ttaggtaata aattgtgata ctcacaagct
    47761 aaaaggtagt cataaaagtt tttagatttt atgtttaaat caattgattt ataatacaac
    47821 attgcttttg ttaattctag aaatgatacc atatagcttt taaagccttc ttttatgtat
    47881 ctagcccata actcaggcat ttcttcctta tcatataaga ttttgaagtt ttgcaggtca
    47941 tacaagcaag aaccaaaatc cctatttact tcttctattg agttccaaga taatttgttt
    48001 ctaattacca tacatgtccc tccaatctaa gatatctatt acatcactgt tttcaaaata
    48061 gaatttattt atataatcct taaaatcttt agattcataa ataacttcac cttctaaaat
    48121 agctttttta agtgctattg tataattatc tgtaacaatt tttaggtcta catcaatgtc
    48181 taatatattt cttagagctt ctgtcttagt tgcaagttct gtaattggta cttttttgat
    48241 gggaatccaa gctatgtcta tatcactttc tgatgtatgt ttatctgttc cataactacc
    48301 aaatattatg attgctagag tattttcttt tggaaataca tttattattg agtttttaat
    48361 ctcatttggt atatttctca tttaatcacc tcttgtttat taggtaatat tgtttagtta
    48421 aataattctc ctttgaaagc tttttgcatt aatgaattaa agttatcttc taactctttt
    48481 aagttggttt ctatttttaa ttttaattta tccacttgct taacaaactc agaaaactga
    48541 ttttgaaatt caattggagg aaccattatt aaatattcac ctaacttact aactgataac
    48601 tcaatttgat tcgttgaacc attaacacat tttctatata ttgtgtcttg tatatttgta
    48661 aattcaaata acgctgcaaa ataatctgaa tttaagttat ttgaaatact tcttaaaact
    48721 gtaacatgac tatctgctat atattcagaa ttatcaattt tgttaaattt tacacatctt
    48781 cctaatgtcc cagttccagt agaatttatt aatatatcat tttgtttcaa aaatatatct
    48841 tctatcttct cttttaagtt ttcatcataa tatttacaat tttctacctt caaatttctc
    48901 cagtatatac atttttgatt tataactttt atatttgatt gctctacata tttaggagat
    48961 acacctcttt ttaaatatat agaaatctct ttaatcttct tcatatcaaa tttttttgta
    49021 ttattaattg gctccccaaa catctcaata aatcttgatt taactaattc atccaatgct
    49081 tctatttgct cttttctttt atttattaac tcttgagctt tatttaaaac ttctaccatt
    49141 ttattttgta tacaaattgt gaaatatggt atttttatat catttaactt gcttttattt
    49201 aaagttgcac ccataactgc tctatcagta ttattaaaat ttaaagttct caaagcataa
    49261 tataaatatt cagatgttat aagttcatta ttttttattt gaaagttagc aattgcttca
    49321 tttgtaaaca tgtcttcttt taatatggca actctaccta tagacaactt aaaactcatt
    49381 acaacggtat ttttaggtac taatttcata ttagcttttt caacagctaa atctgttatc
    49441 tcttcttttg attttgatat atatttttct ttcaaatcag aaattgataa ccatctatta
    49501 ccacttcccc aataatcaga agtatttcta gatggtgttt tgccaatatt tatatagcac
    49561 aattcattta attttatata ctccataccc tatacctcta acattctttc taattcttct
    49621 aatccaacag ctatttcctt ctctaactcc ctaactctac ctataatcac actaggagca
    49681 tcataaacta cttcctcata cactacctct ttatacttat taatagataa atcataccca
    49741 ttctctctta tctcttccac atcaacaaaa aagctttgtt ctgttctttt tctatctact
    49801 tccccatcaa gattatcaaa tctcttaata atatcctcta tatcactatc ctttatctca
    49861 tttctcttat catccaaaga ataaccatca gctttcatat catagaacca taccttatca
    49921 gttccacctg tccctgtttt agtaaatatc attatagctg tagatactcc tgcataaggc
    49981 ttaaacactc cacttggcat tgatattata gcttccaatt tatgattatc aactatttct
    50041 tttcttatcg atttatgtcc acctgttgaa ccaaacaata ctccatctgg cactatacat
    50101 gcgcatcttc caccaatttt taaaactctt aaaaaaagtg ccaagaataa taactctgtt
    50161 ttctttgtct tagtcacttt taataaatct gctgacactg cttcataatc taaacttccc
    50221 ttaaaaggag gatttgctaa caccaatgta aacttatctt tatctgtatt aacctccgat
    50281 aaagaatcct tatactctat attaggattg tcaacgccat gcaacatcat attcatagca
    50341 cctattctaa gcatagttct atccatatca aatccataga acataccatt attaaaatgc
    50401 tccttcagcc cttgcactaa gaaaagactt gaatgattat cccttaagta ttgttgtgat
    50461 gatactaaaa aacctgctga acctgctgcc gggtctacta taatatcttc tggtgttggt
    50521 ttaataagtc ttactatcat atctattatg tgtcttggag tcctaaattg accattagta
    50581 cctgctgtag ccactttgga taataaatac tcatacaaat ctccctttgt atctctatcc
    50641 ttacttaatt ctaaattact aataccatca actattttag ataacataag aggcgtagga
    50701 attttaaata ttgcatctcc catgtacttt gcataagctg agtctttatt tccatgtaat
    50761 ttttttatga aaggaaacac ttcattttgt actatttcat acattttttc tgaatttcct
    50821 tcattagaaa acttactcca tcttaaatgt tgatgttcat catcaaatat cctttcaaaa
    50881 gaaactccca aaagagttgc ttctgcttca ttttttgttt ctacttcatc caatccttta
    50941 ataaataaaa gatatgtaaa ttgttctata acttctaatg gattagttaa tccaccagtc
    51001 caaaatgtct cccaaatctt gtctactttg ctccttaatt ctcctgtaat catatatgac
    51061 tttccctcca gtgttcataa aataatttaa atatatattt tagtcgtacg ccttaataat
    51121 tagtgtctta tattaaattc aaaattttac tacacagtta ttaaattatt tttcctattt
    51181 acatgtttta gttaaaaaac taatgcaata ctcttatttt atgattatta tacatcccat
    51241 acaaaattat tttatcatat atccagcata gaagtcatct acctggataa ctcttaccat
    51301 attataactt tttaatatta atttaaactt agaaagaaat tttttattta attatatcat
    51361 cttccttatt tcaaatttct caattacaat ctcaatcaaa aaataaaata agatgctgtc
    51421 tcaaaataga tataatcttc ttttttattt tcggaatgat gaaaatatat ttaatttcat
    51481 acaaaaaaga gtgcctcctg aactaaaaag ttcattttga gacacccctt aatttaatct
    51541 tacttattct ctccctttat tattaacact tcactatctc tattgctttt cctacacatc
    51601 cacaaacttc catcctactc ttaacaaaat ctttaactga ctctaaacct tttttaccat
    51661 atttcttagg gtcaattacc tctgggtcag aattaagcac atccttaacc ccattgctat
    51721 aagcaatcct taattcagtt gcataattaa ccttgcaaat ccctcttttt atagattcct
    51781 taataacttc atctggtatt ccagacccac catgtaatac taatggaact gatacaacat
    51841 ctctaatttc agataatcta tctaaatcaa gctttggctc tcccttatat aatccatgtg
    51901 ccgtacctat tgctactgcc aaagatgata cccctgttct ctctacaaac tcttttgctt
    51961 ctaatgggtc tgtatatgct cccccatcac caccatctaa atcgtcttcc ttacctccaa
    52021 ctttacctaa ttcagcttca acaggtatat ctgaaggcat acatgcatct acaacagatt
    52081 tagatattga aatattatct tcgtaacttt catgagaacc atcaatcata atagaagtat
    52141 atccaactct aagtgcctgc atagctagtc caaagcttga accatggtct aagtgcattg
    52201 ctactggaac acttgccttc tctgatgcta cctttacatt cgctaaataa taatctagcc
    52261 ctgcatactt tattgttgaa ggtgttgttt gcaatattac tggtgattta agttcttcag
    52321 cagcctctat tactgccata accatctcca tattttcaac attaaatgca cctactgcat
    52381 aatgtccttc ttgtgcatct aataatattt gtttagttgt cactaatgcc ataatttctc
    52441 ctcctatatg tttatactga tttgatttct tcgttattta attttgctac tatttctcta
    52501 cttgttttgc tatttaataa ctcatttaaa aattcttcat tcattaattt tgaagatagt
    52561 tgagataatg tttttaagtg taaattatca ccattatctg tagctgctat cataaatata
    52621 atatgtgcta agcttccatc ttctgattca aagtcaaacc cttcttttga tacacctact
    52681 gctacacgtg gtacctttac tgcatctgtt tttgcatgtg gtatcgctat ccccatacca
    52741 aaacctgtag atgatatttc ttctctttta aggatttctt ctttaaactt ctttttatct
    52801 aaaagaacac tagatttatc aagtattcca atcatttcat caattacatc tgttttattt
    52861 tttcccttaa catctaaaat tactgtttct tcgctatata aagagatatt attagatacg
    52921 ttttccgatt ctgcactttc atttttatgt tcatcttttg ttacatttgt attttctata
    52981 gtatttttct catttactac tttaggtgta accatcatat aaagtacagc acctactaat
    53041 gaacctacaa atatacaccc tacccataaa agtggcttat tgactaatcc tagaaccaaa
    53101 aaccctccat gtggagctgg tacttctatt ttcattatat aagttaaaat tgatgatatt
    53161 gatgatgcaa tcataagtac tggcaacact tttaatggat tttttgctgc aaaaggtatt
    53221 gccccctctg ttatatgagt actacctagt atataattga ttaatcctgc tgctctatct
    53281 tcttctgtaa atctattttt aaataaagta gatgctattg ctattaccaa tggtggtgtt
    53341 atacaagctg cagatacacc tgccataaat aaataatttc cctgtcctag aagcatagtt
    53401 ccagttacat atgctgcttt atttactgga cctcccatat caaatgctga catacatcct
    53461 attactattc ccaaaattat agggcttgaa ttttgtaacc ccgatagaaa gttcatcata
    53521 gcattgttaa gtgctgaaca tggcccacca agtaacaaca ttgctacacc cacaagacct
    53581 acgctgacaa taggaattat aaaaatcgat ttaagacctt ctaattgtcg tggtaatttt
    53641 cttaacaaat gtacaaatag tttaactaag taacctgcta aaaatcctga tatgattcca
    53701 cctaaaaacc ccgaacctgt atcaaatgat atcattcctc caacaagtcc tgctaacata
    53761 ccagctcttc ccgatataga ttgagctata aatgctgcca atacaggaac catcaagttc
    53821 atagaatatc caccaacaga ttttaatgta gctgctattt gattatattg ttctgaattt
    53881 gggtcaaatg aataaatccc ccataaaaat gatatagcag taagtactcc acctgctact
    53941 actaaaggta acatgtgaga tacaccattc attaagtctt tatacaactt ttgaccaaac
    54001 gataaatttc cttcttctgc aattttactg cttgataagt ttccttttct aatagctact
    54061 tttccatcaa tacatctttg tataagttca ttagctttat gtataccttc tttgacaggt
    54121 acttctatta ctggctttcc attgaatctg tccatatcaa catttttatc acaagcaact
    54181 attattgcat ctgccatttc gatatctttt gctgttaact tattttctac acctatagct
    54241 ccattcgttt caacttttat gtcacaccct aattccctgg ctgaattttt taatgcttct
    54301 tctgccataa aagtatgagc tattccagtt ggacaacctg ttacccctag aatcattttc
    54361 tttcccattt ttataccacc tttctgactc ttatattttt tatataatct tccacattct
    54421 ccaaattacc tataccatta ctttcagcca cacttgctcc tgttgctgct gaccttttta
    54481 atgcttcttc aatatgttct ggattttcca accatatact taaaaaagca gctaatgcag
    54541 aatcaccagc acatgcagag ctgactactg taactggttg agcactagca taataaattg
    54601 attttccatt ataaaaataa gaaccttttt ctcctaaagt tagcaatata ttttgagcac
    54661 cttttaaatg tagtaattta agtacatcct taatatcttc ttcatctctt acaataattc
    54721 caaatatatc tttgatttct tcatcatttg gttttatcaa atatggatta tactgtagta
    54781 actcctttaa ttttggtgaa cttatatcga gtattgtctt tatactttta tttttacaaa
    54841 ttttaaatat atcctcatag taattatcat caataccagg aggtagactt ccacttattg
    54901 ataagtaact tatatctgct aatgactgta tcttatctag catatctagt ttttgttttt
    54961 catttacata tgacccagag tttacaaatt taaattcatc acttccatca tttaaaaata
    55021 tatttatacg agttgtatct tctacccaag taggcaatac gtcaaatcct ctcttttcgc
    55081 tttcttcaac tatatatttt cctgaaaatc ctccaaaaaa tcctaatatc ttagattcta
    55141 taccataatg acctagtaca aaagttacat ttaatccctt tccattagga gaatatacag
    55201 catttgatgt acgatttact aattttctct ttatcccatt agtagatata ttcatatcta
    55261 ttgcaggatt tgtagttaat gtatatatca ttgtcttccc ccttgcttgt gctgtgtatg
    55321 ttttcattat aataaaaaag tctatgaaaa tcttttcaca aatagaaaat cgattttcat
    55381 agacttttca atttaatttt cagaattatt atatctgacc atataatcta taattatcct
    55441 agatataata tacaagggca atctggaaga tacttcatat tcagaaattg atatatgttc
    55501 atgtttgtat cctacaatat ataaatccga atactttata agttttgcac tttcactaca
    55561 acagcaagtt ataaccttag ctccaactaa attggcattc tgtgctgatt ctacaagctc
    55621 tatggtattt ccattcaatg aaaatataat tataagttcg tcttttttta ttgatttaga
    55681 ttttattttc attatgttgg ggtcatttat aaaaacaaca ttaaaatcaa gtaattgcaa
    55741 tttaagacta aactcttttg ctacatattc agtaagccct cttgctaaaa tatatatctt
    55801 actagattta tttatagttt ttattatatt gattagtgta gttaaagata tttgttctat
    55861 aactctctgt gcttctataa aggatttatt tattatatcc cccatatttt gtatatcatc
    55921 attttcatct tttactgtta atctatacct aagttcattg aatccattta aaccacattt
    55981 tctaattgct cttgaaacgg ttgctggaga tgaatatgtt tcatgagcaa tctctactat
    56041 agataattct ggtaatattg attcattttc atttataaat ttaattattt caagttccgt
    56101 cttcgttaga ttttcagaat tacttttgtt tagctcaatt atcatatgtt atctcccctt
    56161 atataagttt tatttgtcta aatttatcga gtaatataat atattacctc ttaactactt
    56221 atttttatat acaattaaga tttagtcaat gtctatatat gtaaatttat aatataataa
    56281 ttttttgctt aaagtttatt atgttatctt atagcatttt aaaataaaaa agaattgtac
    56341 ctctaccaaa atttggatga agtacaatag atattcctca tactgatatg tttatgatta
    56401 aaagtataaa tataaatttc gctatgaatc atataattaa taaatcattt tatttacaat
    56461 tataaccccc cttataaaac tatattaata atatatacag tatttataag gggggttgtt
    56521 tatatttaaa aactatttac ttttctctta attcttctcc attagttctt attacatttt
    56581 gataccaata aaaactatct tttttataac gttctttact tccatttcca ttgttatcta
    56641 tatccacata tataaatcca tatctttttt ccatttcttg agatgaacaa cttactatat
    56701 ctattggcga ccacatacaa taagctaata tttcggttcc atcagctata gcttcaccta
    56761 tttgttctat atgttttcct aaataatcta ttctgtaact atcatgaact tttccatctt
    56821 caaatttatc atgcattcca aatccatttt cagctatcat tattggcttt tggtatctat
    56881 cataatattg agataaagta ttgtataatc cttttgggtc aattgcccac ccccaaggat
    56941 ttgcttttaa atatggattc tttatattgt cagttggatt catggtgttt ttacttgctg
    57001 atactgttgt agaataatag tatgataaag ctagaaaatc catagtattt tcttttaaga
    57061 ttttatcatc accttcctcc ataactatat ttatgttatt ttctttgaaa aatctcttaa
    57121 tatagactgg atactctccc ctaaaactta catcagtgaa aaaatattgt agcctatttc
    57181 tttttaaagc aaatactaca ttttcagggt cacaatcttc tggataagat gtacaatctg
    57241 ccatcatcat acctatcatc atatctgaat ttatttcttt tccaagcttc ttagtcaaag
    57301 ctgtagctat gaattgatga tgaatagctt gatatctagt ctcttctaca ttatcaactt
    57361 ggtctacaca aaatgcaact gaattaaatg attcataatg tattaaattt atttgattta
    57421 taactatcca atatttaact ttatttttat atctatttag tattaattct gcatatctaa
    57481 caaagaaatc taccactttt ctattagacc atcctttata ttttaatact aaattcaaag
    57541 gagtctcata gtgaagtagt gttacaatag gttccatacc attatctatt acttcattta
    57601 taagattatc ataaaacttt aatccctctt cattaggctc taaatcatct ccatttggaa
    57661 atattctagc ccaatttatt gaaaatctaa aacactttaa ccctagctct ttcaaaagct
    57721 ttaaatcttc tttgtatgta tgataaaagt ctattccact acgcttagga taatatccat
    57781 tattatcttt catagcaaac tttattcttt ctatagtcat atcagactca taaggtttag
    57841 atatatctct atctttatca tacatatgta catcagctaa acaccaacct ttgccacctt
    57901 cattccatgc accttctaat tgattagctg ctacagctcc tccccataaa aaacctttag
    57961 gaaacttacc caatttaatc actccttatt ttatttattt aaatcattta ctattattta
    58021 ccttatattc tatagacttt actattccta ctaaagacat agttatattt aactcgctga
    58081 atatggtcat aagagtatct tgagcatgtg caaataacag cgaatgtgct cttttctctc
    58141 caccagcttc cccttgtata atcttggttt gagctctatg tgcttctgtc ataaaccctt
    58201 ttgctttagc tagttttaaa tcagcatttc tataatcaaa cttttccaaa tcattaagag
    58261 catgtttaat ttctgttcta gcctcacctg cacgaagtat tatttgcatt gctacttcta
    58321 ctaattcttc atctattata tgttcttcaa ttgtcatatt tataatttcc tttcaatttc
    58381 taaatttaaa cctcttgact ctctaatttt atctcttctt tctcataagc tttaaaaaat
    58441 ggataccata tcataaatag caatactata tttattgcta aaacaataag acctctaaca
    58501 tcttgattta ccataaaagt agatatacca aaaggaacat accataaatt aaacacctta
    58561 cttggaattg taacaaatcc catactcatt gataaataag tagttattga tattactact
    58621 gttcctatcc acataggtaa cattaaaaat gggttccatg ccactggagc tccaaatatt
    58681 actggttcat ttatattcat tatagaaggg acaatacatg ctcttcctat tgcttttatt
    58741 cttccaactc tggataaaca catcattata actaatggta atgtagcacc caaccctcct
    58801 aaagttatcc agcctgtttg aataacttcg taaacatata tattagttgc tactcctcct
    58861 gatgctactg ctgctgcatt agctgcaatt gcaccaagtt gaattgaata agttatagga
    58921 gatagtaccc acccacttat tcctaaagaa tatataaata ctactaagaa gtttaagagt
    58981 acaaatccag gtaatgtctg tgctatatct gatactggtt taaatactct aactattatt
    59041 tcaaacatgt caaagttgag tccataaatt aatccccagc ctacaaacat tatcactgtt
    59101 ataggtaaca tattatcaaa ccacttgctt acaaaatccg gaagtgctga atcttctccg
    59161 aaaaatgaaa aagaaccaaa taaagacatt attaatccag agaataatcc tgcaactagc
    59221 gatacaagca ttccttctcc tccaaacctg ttgaagttaa atatagctcc ttcattcgta
    59281 atctctggac gaatcatcat taacattaat ccagcacctg caagaccagc tactacactc
    59341 atactttcaa atttcttatt cttcattgtt tccataggca ataaaaatgc tataaataat
    59401 cctaaaagtc caaatgtata ttgatttatt ggacttaaat caggtaaaaa gcttatgtaa
    59461 ttcttcaaga cagaaactat agttactaat gagcctacaa ataccattgg caaaactttc
    59521 attatagttg attgaactga ttgtacccat atattcttag tcatattatt tacaacagga
    59581 gtaaattttt cacttaaaaa atctataaat ttattcataa acactctccc cataaatatt
    59641 ttatttgttt gatattagtt ctagtgcttc ttccaaagcc tttgcaccat ctagtcttcc
    59701 atatgcagtt ttagatatac atgctactgg aacgttatat tcattagcct tttgttgaat
    59761 ttcttccttc atataatcta aatgtggtcc tagtaataaa caatctattt ctgataaata
    59821 cttatctatc tctgactcac ttctcgcttt tatatctgct tctatacctt ttttctttgc
    59881 actctttctc atactagttg ccataaaacc tgtacttgct cctgaaccac acgccaaaag
    59941 cactcttata tttttcataa taatacctcc aatattttta tccattaatt tatttcttaa
    60001 tgaacttttt attttattat gtttatattt tacttcccaa ataagttcat ttcacataaa
    60061 tatatttcct aataatagga aatcatttac tcttaattag acctattaat atagtataat
    60121 gtatcttata atacgtacat tcaattatat aattatcata tcatacagat tttattttaa
    60181 aactatgcga gggaatctaa tgaaaacatc taaaaaagag ctatttttaa atttcataaa
    60241 aacgcaacat gattggatag attcatccac attagctaat taccttaatg tatcaacacg
    60301 ttcgattaga aaatatgtaa acgagattaa ttctaatggt gcatttatat tatcttctaa
    60361 aaagggctat aaagtaaatc tcaatactaa ttgtcaaact aagattgata gttcagagaa
    60421 tatatcacct gataacagat taaatttaat tttaaaagaa cttatagtta atagtaatgg
    60481 aattaatata tttgatttaa gtgaagaatt atttgttagc ccagctacta ttgaagggga
    60541 tatagtcaaa gctaataaat ttataggaag ttataattta aagataaagc aatcgaaatt
    60601 tttattgaaa ctagttggaa atgagtctgc aaagcgcaag ttaatgagct ctataatatt
    60661 taaagaaacg ggaagtgatt ttttaagctt atttgatgta caaaaaatat atcaagagta
    60721 taatttgact aaactaaaag aaaatataat atatatat
//
LOCUS       DAEHWM010000011        59526 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.012, whole genome shotgun sequence.
ACCESSION   DAEHWM010000011 DAEHWM010000000
VERSION     DAEHWM010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 59526)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 59526)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..59526
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.012"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            493..1530
                     /locus_tag="KNP36_000738"
     CDS             493..1530
                     /locus_tag="KNP36_000738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872629.1"
                     /translation="MLKKWFGIVKKRQKSESVKEEGEVILKNEKILSEEKLIDEEGVV
                     VNIDNQILTKVVNDDNEIEEKIIEEDLLISENTIKLDDKEAIINDKNIELCKKEVQVE
                     SEKIGLNKFEGLDQNENYNLEKNVIEEKKVSECLTEEDLEYIKEIKIKRGKSIKAINL
                     YTKEEWVFDTHIQCSKKLKVPLGYIRENLKYGYMDYFGDAINYLSEVLNIDEYCKSEW
                     SYLDNSKSPSEIFNILNNKIFSIRLSNEKRNEILTNDKIEALKMNYRFECIDEEYDEY
                     FKKYKSIIKRGGKKKVELVNKKGDILEIFKSLEECAIYLQKEKNEVIQMLKYGDTKVG
                     RNFIRYSLRSI"
     gene            1641..2783
                     /locus_tag="KNP36_000739"
     CDS             1641..2783
                     /locus_tag="KNP36_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBF0872630.1"
                     /translation="MSEEKNPKENTLDESKNSDNVNSKKDDVSDEKNTDNKVKKREIK
                     LNNKTLKAIVAIVAVGAICLGGGYVFGKEAGRKLPATSKHYNSSEVVATIGDKKITGE
                     MLRKRMEPLFYLNAKTTMTDDEIRSYESNMIETMITSDILSSEAAKEKISITNDQLDA
                     QYNNLMSSIESAMGMTKEEFLKQFDLTEKYIKDDMKKELVASKYLNEKSKVTDKEAEN
                     YYNKNKSNYLQVRASHILIKTVDDKGKQVSSSKKAELKKEAEEILKKAQAGEDFATLA
                     KKYSEDSSAESGGDLGFFGKGQMVESFEKAAFALKKGEVSNKLVESDYGYHIIKKTDE
                     KYQPFEEVKSDLVSSLTSEKQNLLIQNLKEKYNVKITDKYQMKAKE"
     gene            3237..4628
                     /locus_tag="KNP36_000740"
     CDS             3237..4628
                     /locus_tag="KNP36_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBF0872631.1"
                     /translation="MSSTESVSKKSGHPKSFWLICMTILWERFSYYGLTALLVLFFTA
                     SVAQGGLGLSTQEATSMFGLFTGLIYLTPLVGGWLADKVLGQQKCISIGALLIAIGDF
                     VLFASSTSIAMVWVGLSIIILGNGFFKSSCSNIVGDIYPKTDVSRKDAAYSLFYMAVN
                     VGAFIAPIICGLLSDNVFAVRGASGDIVSYGYKMAFLICGIGMMLGMIIFTLLAPKLL
                     NEVGKYPVTKGNKGEKIEYGPLTKLEKNRIIAMVILFLFVVLFWTAYYQTQSSFMIYV
                     RDNVNRTLFGFEMPVAWLTSLNAILCVALCPVLATLWVKLSHTKRGDFSIPVKMGLGM
                     IIMGVGFIVMVFATLANGPDGMVKASILFIVLTYIFTTVGELFLSPIGLAMFNKLAPA
                     KYATLSMGAWYLTSFFASLLSGKIAGFTATLGFLQIFGGIATVLIIFGLILLGIRNVL
                     TRLMAMDLLTKEK"
     gene            4881..6674
                     /locus_tag="KNP36_000741"
     CDS             4881..6674
                     /locus_tag="KNP36_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0872632.1"
                     /translation="MNIKDRLSGLRKFMEEKNIDAYMIPSSDNHQSEYVGDYFKSREF
                     ISGFNGSAGTVIVTKDEAGLWTDGRYFIQAESQLEGSTIKLFKMGQEGCPTTDEYLYK
                     NIPEGGTLGFDGRVISAREGATLAEKLSKKGIKIEYQYDLIDSIWPDRPALSDSKAFL
                     LDVKYCGESFSSKLARLREKMSEKGTSTHVITTLDDIAWLFNIRGGDVKYNPVVLSYA
                     VITLKEVYLFVDESKLNEEILNELAKENVQIKPYNDVYEFVKNIDKTEKVLLDGTKLS
                     YTIYNNIPCEVEKVDEFNPVMFFKAQKNEVELENIRNSHVKDGVAFTKFMYWLKKNVG
                     KMEITEISATQKLEDLRREQEGFFEPSFNTIAAYKEHAAMMHYSATPESNYKLEAEGL
                     FLVDSGGQYYDGTTDITRTTVLGPISDELKLHFTSVARGMINLSKAKFLHGCRGYNLD
                     ILSRSCMWNMGIDYQCGTGHGIGFVLNVHEAPNGFRWRVVPERFDSAVLEEGMVTTNE
                     PGIYIEGSHGIRTENEIVVRKAEKNFYGQFMEFEVVTLAPIDLDGIAPELMNKDEKDY
                     LNWYHKLVYDKISPFLTDEEREWLKVYTRAI"
     gene            complement(6755..8137)
                     /locus_tag="KNP36_000742"
     CDS             complement(6755..8137)
                     /locus_tag="KNP36_000742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBF0872633.1"
                     /translation="MSVLKTQEKLKQPRDLYFCCSIFTFVGLAYYGMKLVLLLFLAEQ
                     VSKGGLGLTPAESASMLASFLAWTYFSPVIGGWVSDRFLGPKNCIILGMLMVSIGYFL
                     GYIANSKMDINIMIFLSGLGIGFYKGNLHTMVGNLYTNDDPRKDGAFSITYMATNLGT
                     LFGPLICGLVANEWFAMKSGLSISMYGYRYVFLFSSITVLIGLFFFIFGNRKFYKPLN
                     NDPINGRESIRKSLEYKKMLASRPLTLIEKKRIIVILVLAFFTVFFWIAYNQASMSIA
                     LYTKEHINLTVGNFQIPTSWIDSYNGLLCVILGPISALVWVKLSQTKKGDLSVPKKMS
                     LGFILLAIAFLFMIVAVIQTGTDPNSIHKASVFWVVGFLTFQSIGEICFSPVGYGMVN
                     KLSPEKYISFLMGVWFLGKFAANKLSGYTQAIIDQLGMLQVFIVIPSFLLIFGIILLI
                     MNKKLVELSN"
     gene            8395..8742
                     /locus_tag="KNP36_000743"
     CDS             8395..8742
                     /locus_tag="KNP36_000743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBF0872634.1"
                     /translation="MIRKKSELQVEVKENLNGGIGKVKLENIIQNEELKGKGRLFKRV
                     ALPVGSSIGVHDHTTDFEVYYILKGKGKVFDNGEFVEVNEGDVVYTADGEKHSIENIG
                     EEDLEFVALVLYM"
     gene            8760..9794
                     /locus_tag="KNP36_000744"
     CDS             8760..9794
                     /locus_tag="KNP36_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872635.1"
                     /translation="MTGKIEEIKDKINRFCNSNLNQEYKDISFKILQNLLDNNKEIIH
                     SSRADIWSSAILNIVLEQNLLYNKKHPLHITKKEFSKQIGVSLNTINNKSSLIKDVCS
                     IDFLNQDTIAISNVEFWVKETNSKSKSVDLDLEKKKILYKRYIKLSQDANSDIESIRY
                     MEEAVNIGKSMITKEDKELGFWKGLSTRAYMIALESLARKLESINNLKESKKVLEYLI
                     EINPSDEQGIRYKLLNVLIRLNDRTSINKLFELYKEEKSATWMYSKALYYFKNKSMFL
                     ANDSIKVARSKNKYVGLYLLDWRNAFGREFVTEEEKAEAVYYYDENIVIWNEVKGSMD
                     WLLKKMLEFS"
     gene            complement(9843..10892)
                     /locus_tag="KNP36_000745"
     CDS             complement(9843..10892)
                     /locus_tag="KNP36_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872636.1"
                     /translation="MEINYKKRNFKSFAKRKNIEISVQRYLIDALSYMALGLFSSLLI
                     GTIFNTLGDNFNISLFTEVISPLAKQVTGPAIAVAIAYGLQAPPLVLFSCALVGACGN
                     ELGGPVGAFVATLFAVEVGKLVSKETKIDILVTPAVTILIGVLVAELIGPAVSAFMTS
                     FGNIIMQATTMQPIIMGALVSALVGIALTLPISSAAICMMLSLGGLAGGAATVGCCCQ
                     MVGFAVMSFRENGVGGLVAQGLGTSMLQVPNIIKNWKIWIPPTVASILLGPLSTTIFK
                     MENIPIGSGMGTCGLVGQFGTVTAMQSAGKGGISMWVGILLLNFILPAIVTLLISEFM
                     RKKGLIKPEDLKLDV"
     gene            11167..12702
                     /locus_tag="KNP36_000746"
     CDS             11167..12702
                     /locus_tag="KNP36_000746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872637.1"
                     /translation="MIFVKNKKYRKIAIIISIPILLVAQYYLFKFGILRPMVKGVEIE
                     IVDGEYVKDIDKYVVKLNETVTLSTGEYIKVPSYAKNPNIWFNVLDNSGTLKIDGNKM
                     TALKVGYSSVGIMKNSRVLKKATIKVVDPEVESLDMEINGDLKHVGDSATIESTIEVD
                     YDKFKKSYKPVYKSSNENILKIKGNKVSAVGVGKATIYAKCGNKEIERTFRIQARVAE
                     INMDDIKIEVDQNEKLKPDIITSPPGLEPPKIYYELVDSKLPVERAISLSSNGNVVGL
                     REGKDRVRITCGDKSKVITVTVVKETITNDYIQNLVGSHKIVNNKVIIKLEWDYMKDV
                     FDYDIYLKDKLSGESFKKIKSITINESDLGKSNKVYATIEVDMKGNQNIDFDIYVIGK
                     KDSDTTKPSNVINITNGNGNSNNDNNIKDMRVENISANVDRDNNVIRVNWSSISHKDC
                     TYSIYVKNNTNGDGEFTLYQSDIQGNEHTISIPEGDLNLDIYVVANYNGNSSQNSDVI
                     NVR"
     gene            complement(12887..13573)
                     /locus_tag="KNP36_000747"
     CDS             complement(12887..13573)
                     /locus_tag="KNP36_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="HBF0872638.1"
                     /translation="MKTIGLIGGMSWESTITYYQVINTVIKERLGGLHSSKCILYSVD
                     FQEIEECQSSGNWEKSAKILADAAIKLQEAGADFIVICTNTMHKVSDKIQESIHIPLL
                     HIADVTATVLREKEIKKVALLGTKYTMEQDFYKNVIINNGIEVLIPNEEDRIIVNDTI
                     FNELCLGIISESSKKAFLSIIDKLGKQGAEAVILGCTEIGLLIKQNDTSIPLFDTTVI
                     HAIEAALSSI"
     gene            13698..15080
                     /locus_tag="KNP36_000748"
     CDS             13698..15080
                     /locus_tag="KNP36_000748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0872639.1"
                     /translation="MPINSFENYPMTWKPKLDNRKPPIYKTLAMLLEEDIKRGNLNPG
                     DKLPPQRELADFLDLNLSTITRAFKLCEEKGLICAKVGKGTFISSDVNVSNTLLYQTE
                     SKDIIELGTVHPPYEQNTYIIDFIKNVLKQPEMDRFLQYMSPSGTYMQKKSIAKWIER
                     NNVYTSEENILLSTGGQNAICATLLGLFKAGDRIATDSLSFSGIKSIAKMIGIQLVPI
                     PQENNEISIEYLESYCKNENIKGIYLIPDYHNPTTHTMSDLSRKKIAKIAKQYNIIII
                     EDAINSIFRDGIQTPIFSLASDNTIYIFSTSKFLCAGLRVAFVVAPKRYIENLENALY
                     NMNLMVSPFTAEIVHRLLYSPIIDKIIEEKRDAIIERNEVADKVLSDYNLIGDKNCSF
                     RWLLLPDELDGKSFEISAKNLGVQVYCAERFSVGNSTVPKAVRICVTAPKDVEELEKG
                     LNIIKSLLKS"
     gene            15482..16750
                     /gene="eam"
                     /locus_tag="KNP36_000749"
     CDS             15482..16750
                     /gene="eam"
                     /locus_tag="KNP36_000749"
                     /EC_number="5.4.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 2,3-aminomutase"
                     /protein_id="HBF0872640.1"
                     /translation="MNEQTRISLERAAELKSKIDDYIQARKTINRGLEKEEEINKRKQ
                     KILSILNGTEEDWNNYKWQLSNRITDVDTLSKIITLTKKEKEYIKEVGTQFRWAISPY
                     YLSLIDPEDTCDPIKLLSIPTHIELEDEQEDLDPMGEEYTNPAGCITRRYPDRLIINV
                     TNECAMYCRHCQRRRNIGQQDSHKSKAIIQESIDYIRENEEIRDVLVTGGDALTLKDD
                     YLEWILSQLKEIPHVDYVRLGTRTLVTMPQRITDEFCNMLKKYHPVYINTHFNHPMEI
                     TKESKEACEKLANAGVPLGNQAVLLNGINNDKFVMRCLNQELLKIRVKPYYIFQSKHV
                     KGTKHFNTSVDDGLEIMEYLRGYTSGMAIPTYIVNAPKGGGKTPLLPQYLVSKGTDYV
                     MLRTWEGKVIKMEDEPAVDIKKLIKEQAQD"
     gene            complement(16843..17199)
                     /locus_tag="KNP36_000750"
     CDS             complement(16843..17199)
                     /locus_tag="KNP36_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872641.1"
                     /translation="MKKALISLLVLSCLLLTAPVNESSYADSQKNVPVSQNTKLTQEQ
                     AKELLVKYNNEVDYIYQGNASDFEALKAKNLNGYVFLPDADGDIGYFVNENTSEIYYF
                     HPSGYLELVNQQQNNK"
     gene            complement(17350..18444)
                     /locus_tag="KNP36_000751"
     CDS             complement(17350..18444)
                     /locus_tag="KNP36_000751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBF0872642.1"
                     /translation="MQDKKIYLNIVLTVVVSYILIKVIDNYKYFFGVISLLMSLLTPF
                     IIAFVLAYIFNPLVKFLESKLNFKRIYSLLLTYGVLIVILISFILFTVPSIVNSLADL
                     VAQIPTYIDKTEQFLFDLGKSLQSVDPNTLKEYGDKIMSVMPKFSNLLIGSLGGIFST
                     TFSVGKFIVQFLLGFIICFYILLEKEKFLLFTKKVVYISLGKKYGDFIIELCQSLNLN
                     IGKYFTGKILDSFIVGVLSGIGLYFLKSEYALLFGTLMGVMNMVPYFGPVIGMAPVVI
                     INLFSNPTIALTSLIYLIIIQQVEVTFIEPKIVGGQLGLSPFFTILAVTVGGGFFGIP
                     GMILSAPVMGVIKIYFCEFVNRRHDKIQME"
     gene            18908..19729
                     /locus_tag="KNP36_000752"
     CDS             18908..19729
                     /locus_tag="KNP36_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MoxR family ATPase"
                     /protein_id="HBF0872643.1"
                     /translation="MIKKEISNFRGSSDYVVSPELMASVNVAIALEKPLLIKGEPGTG
                     KTMLAQAISNELKKDLVIWNIKSTTKAQEGLYVYDTVQRLYDSQFGGEGVDDISKYIK
                     YGKLGEAFSSNQQVILLIDEIDKADLEFPNDLLWELDKMEFYINETKETVRAKQRPIV
                     IITSNAEKELPDAFLRRCIFHYIEFPDRDMMEEIVKVHFDKVEEHLLEQVMTTFYWIR
                     SLKDIQKKPSTSELIDWIQALTLSGMPIEKIEKEVPFAGILLKNNEDIESMQRHL"
     gene            19750..20946
                     /locus_tag="KNP36_000753"
     CDS             19750..20946
                     /locus_tag="KNP36_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VWA domain-containing protein"
                     /protein_id="HBF0872644.1"
                     /translation="MFIEFFYLLRSRGLNVSLNEWMTLIEALDKGLCYSNFSNFYYLC
                     RMILIKSESDFDKFDAVFLEYFKGIEHQEEIPEEIMNWLKKPDIDLEEFERLEQNPNI
                     NLDKLRAKLEERIKEQDSPHNGGNYWIGTGGTSELGHSGKGQTGIRIGGNSTYGRAVL
                     EVAGERKYRDFRDDEVLNMRQFQVALKRLRQFSTRIDAPKTELDLDKTIEETCNNAGY
                     LKLFFEKPRKNTVKLLLLMDSGGSMRGYSTLCNTLFQSVSKSNHFKDVKIYYFHNCIY
                     DRLFTTPECWLSKSINTEWILKNIDKNYKVIIVGDASMSPSELLHIGGNYRGPYNYTP
                     GIEWLKRFKRKYSKIVWMNPELRDGWDSISYWYQTQRMIQSEFNMFPLTVKGLEKALK
                     NLMVSR"
     gene            21113..24511
                     /locus_tag="KNP36_000754"
     CDS             21113..24511
                     /locus_tag="KNP36_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBF0872645.1"
                     /translation="MIIINYELIVKYNGDILRLEEELGVSVEILNSSYAIITSSNEED
                     VNILLTYPEIEFIEKPFILQTQDVQSFSSTGITGFKNRTGLTGKGTIIGIIDSGIDYT
                     LPVFRDSDGRSKILYYWDQSIQGNPPEGFREGTLYTNEDINNAIDGSMYIPISTTSLH
                     GTHVAGICATIASDARIIVVRVGNIQTDIFSRSTEFMRAIKFILDRALELRMPVTLNI
                     SYGSNEGSHRGTSLFEQYIDDMCLFWKNNIVVAAGNNADKGGHKRIRLQNNITEEVEF
                     IVGEGERILNINIWPDFVDDFSVHLVNPSNNQTQAISLTSGEIRNTLGETRITGYFYP
                     IAPYSLTRRVTLQLSSNTQITPGLWKIVFEPIDIVTGNVNIYLPTSEGLNRNTRFLIP
                     TQELTVTVPGTASRVITVGSFNSRTDIVSIFSGEGDTQLGVFKPDLLAPGEDIVSFLP
                     GGTSGALTGTSMATPHVTGVCSLFMEWGIVNGNDLFLYSQKLRALLLKGARRLSNQSY
                     PNNSSGFGFLNLSDIDLYTLSNINQDLETEDIGYRSINKSFKDEENSYKFIDGYNMQI
                     HNDLENEIYISKNASRQSGILSGIDIVHTPEFEEELAGLGMSQRFFKISDSLGVLSIN
                     NTDYNSIQRVLQLPSIIRTVSTTKMTLLGEINRGTFGGVVATEEMGVNFFKNNPNINI
                     TGRGTLISIADTGIDYLHPDFIYPDGTSKIVYLWDQTKEGTPPDGFYIGTEYTREDIN
                     RAIAENDPSLSQDEVGQGTMLSGICAGLGNVNSEYAGIAEDSELIIIKLGKIDDFYNS
                     AMLFAASQYAYKKAFELGRPLVINMSLGTSSLAGLTNRSNSEKAFFTRGLCITAGAGN
                     EGNTQTHTSGIIPYVGGSVEVELELNEDEEELSLELWLNRPDKADVIIVSPTGEESKS
                     VGISNYNKVTGLFDLEGTEYSITYIYPTTFSGQQFTNVTLKNAKRGVWKIRLVGVYII
                     TGRYNLYLPNRELLKSGTRFREVDPFYTINYPAIQDDLITIGAYNTINGSLWQSSSRG
                     PTIEDRLKPDIVAPGVNIIAAYPGNTYATITGTAAASAHAAGAAAMYFQYTFVDGRYP
                     NQAYVQKIKTFMQAGARKDSNTVYPNTNSGYGLLDVRGMFDVLR"
     gene            24521..26194
                     /locus_tag="KNP36_000755"
     CDS             24521..26194
                     /locus_tag="KNP36_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBF0872646.1"
                     /translation="MEKSYCIIYQGDIESALQENGINRYMVLNSQLAVIYVPLDFDET
                     ILNNIIQVAWWEESEPMSSLIEITNNVNNGETITTAAETDYIYENPYNDITGRGILLA
                     VIDSGIDYLHPDFINDDGTSKVLYLWDQEANTNPPPEGFIFGSEFTRSELNIAINRND
                     GSLSQDNIGTGTLVSGILVGNGRINSQYRGITTESDLIVVKLKSYTDTYYAGRINYSV
                     SDFLAAITYVTNIARTENKPLIINLTIGVKSSAVATTSILDTFNILSSAGVVVVSGAG
                     NQGNTDIHYSGRFSSVGEVQDVIIQDGDDYALDITLNTNGPDKVGAQIISPSGEVSHD
                     IRYSPDFYIYRGKFNLENTTYAMRFIYPYITSGKENLEIRLRDIKPGVWILRLTSELI
                     INGEYDIYLPNKNLIAPDTRFLEPDSVATITMYAASDDVITVGTFNNKTDSMWIGSSK
                     GPIRGRGIKPDIVASGVDIISTYKNGTYNTGTGTGVSSSIVTGVLALLMEYLEKQDNV
                     PRLSLFTQVLKTYLILGATKLEIYTYPNVSQGYGILNLKNTIQQIANTL"
     gene            26467..26661
                     /locus_tag="KNP36_000756"
     CDS             26467..26661
                     /locus_tag="KNP36_000756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3787 domain-containing protein"
                     /protein_id="HBF0872647.1"
                     /translation="MESKKARALKGKDNKRLKSSLLVGNESTAAWADVEKLKPHSKVS
                     IPSIKGVEEAKDWVDNGSKL"
     misc_binding    26830..27063
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            27140..28537
                     /gene="asnS"
                     /locus_tag="KNP36_000757"
     CDS             27140..28537
                     /gene="asnS"
                     /locus_tag="KNP36_000757"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HBF0872648.1"
                     /translation="MQKEFITVKELYREKEQYIGKTVKVAGWIRTSRVSKNFGFIELN
                     DGSFFKNMQIVFDEKVENFKEVGKLAISSSILVEGELVSTEGAKQPVEIHAKSIVVEG
                     ESDSSYPLQKKRHTLEYLRTIAHLRPRSNTFSAVFRVRSIAAYAIHKFFQERNFVYAH
                     SPIITGSDCEGAGEMFRITTMDLNDIPKTEDGKIDYTQDFFGKEANLTVSGQLNAEIM
                     ALSFRNVYTFGPTFRAENSYTGRHASEFWMIEPEIVFADLEDNMELAEDMIKYVISYV
                     LENAPEEMEFFNSFIDKGLLERLNKIVNSEFIRITYTKAVELLIESGHEFEYPVEWGC
                     DLQTEHERYITEQIYNCPVFVTDYPKDIKAFYMRMNEDGKTVRAMDLLVPGVGEIVGG
                     SQREEREDVLLDRINEMGLREEDYWWYLELRKFGTATHSGFGLGFERIIMYMTGMSNI
                     RDVIPFPRTPKNAEF"
     gene            complement(28710..29885)
                     /locus_tag="KNP36_000758"
     CDS             complement(28710..29885)
                     /locus_tag="KNP36_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0872649.1"
                     /translation="MNLEKIKKFFGFPLDKKHKDNVEKELCNYLYHTGKIICIIIVIS
                     QIIMMISISAREGGPFVTPRRQWYFYMYVTLFCVSSVFMFVFSYLWNKKKDCCTFYIN
                     LWIIYVTFFCLWGCVITLLDQLGGNDLSVFSYIMLAAAAFSVLKFGESVIVFGGCFLF
                     LNLFLPGIQTIPGNEFSNIVNTFFITSLAIFVSTMLYRNRVFTYYDKLLISQQYEEIS
                     HINNLLNDKVMTDDLTKMNNRRYLEDILQKKLISHANQEPITGMMIDIDYFKQFNDNY
                     GHQKGDYCLQNIAKVILDFTSSENEHAIRYGGEEFFICIFNCNEADAKLKSECLRKII
                     ESCNFERDDVPLKCVTVSIGVYTKKIGKTITLNEFISNCDKALYTAKEQGRNCVAFY"
     gene            30304..31668
                     /locus_tag="KNP36_000759"
     CDS             30304..31668
                     /locus_tag="KNP36_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0872650.1"
                     /translation="MGEKKINNMNYSHNNYSKKTGEPTRKIKNSHITLKSKEEKICSS
                     CNKENNTKDNYCKFCGNELYEIASLRPLETKLDLKSKIKELSYHANKRGVFLTTFTTI
                     FILFIIALIFKAIITIQFNDISYLINPAHIILALNLGQISVSMSTMMGSGFINANIGL
                     LILLIIPILVLLISNLIFMRKRCRDSKTVLANSLGVGIFYGLVLAILSIFTNVKTSSH
                     SMLEYGYALEYSYEFFSVLLNGFVLGFICTYITTYKKSYEKENMYLSLFSNSIRTFIL
                     GYVLVLVILLVLTISDSSYLNELDMSSYSNGLNLFTILPQIASYMWAFANGISVTIIN
                     STVSMFTLSSSSLFGDTKLMFYAMGALSMLILLLNGYKLRFKYNTDSIRPIIVFSIYY
                     AFLMGILALFSTFILDSNINFFNTTNYGTTLIMQFKVLQAIVISFVYSFVISLIGYKL
                     NSAD"
     gene            31690..32181
                     /locus_tag="KNP36_000760"
     CDS             31690..32181
                     /locus_tag="KNP36_000760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0872651.1"
                     /translation="MEGNTNNKVDDKFSKVKKKFGSGKFKVELYKEKSKLNREIDDIQ
                     EKKAKIFLEMGILTYQKIREDSINDNSFDKFCDELLELDKLIYEKNMEINEMEMAESN
                     VTCECGYVGNVNDKYCAECGKKFELENECDDFIICGYCESEIDTEAEFCPCCGRKIIM
                     DLE"
     gene            32454..33125
                     /locus_tag="KNP36_000761"
     CDS             32454..33125
                     /locus_tag="KNP36_000761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HBF0872652.1"
                     /translation="MLDKVKGRLIVSCQALEDEPLHSPFIMGRMAKAAMEGGAVGIRA
                     QGVEDIIEIKKVTGLPVIGIIKRNYEDSDIYITPTKKEVDELLTTGCEMIALDATNRV
                     RPNNEDLKELIKYIKENGVLVMADISNYDEAIKAQEYGVDCVSTTLSGYTPYTKTLEG
                     PDFVLMERLVKDLEIPVIAEGKVNTPQDLKKVFELGVHSSVVGSAITRPQLITEKFVK
                     AIEIN"
     gene            33210..34076
                     /locus_tag="KNP36_000762"
     CDS             33210..34076
                     /locus_tag="KNP36_000762"
                     /EC_number="4.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HBF0872653.1"
                     /translation="MKGIYSALLVSFDKEGNINEKGLRQIIRHNIDVCKVDGLYVGGS
                     TGENFMLSTDEKKRIFEIAKDEVKEEIKLIAQVGSVNLKEAVELAKFTTDLGYDAISA
                     VTPFYYKFDFEEIKHYYNTIINSVDNRLIIYSIPFLTGVDMSLDQFGELFENEKIIGV
                     KFTAADFYLLERMRKTFPNKLIFAGFDEMMLPATVLGVDGAIGSTFNVNGVRARQIFE
                     LTKNEKISEALEVQHVTNDLITDILGNGLYQTIKLLLEEQGVEAGYCRQPMKEATDEM
                     KSRAKEIYRKYF"
     gene            34109..35611
                     /locus_tag="KNP36_000763"
     CDS             34109..35611
                     /locus_tag="KNP36_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBF0872654.1"
                     /translation="MVGFTWIDFAILVVYLLAVLFAGLLFSKKEMKGKEFFKGDGTIP
                     WWVTSVSIFATLLSPISFLSLAGNSYGGTWILWFAQLGMFIAIPLTIKFFLPLYSRLE
                     IDTAYEYLEMRYESKGLRVLGALMFIIYQIGRMSIIMYLPSIVLAGLTGIPVNVLIIV
                     MGVIAIIYSYTGGLKAVLWTDFIQGMVLIVGVTGTLFYLIASINGGFGTVMDTLTTGH
                     KFLASNEVMFDKNILSTSAFIIFVGAGLNTFSSYVSSQDIVQRFTTTTDIKQLNKMTY
                     GNGVLSMGLATVFYLIGTCLFIYYTQNPDLAQTVQQDQVFASYIAYELPVGITGILLA
                     AIYAASQSTLSTGLNSVATSWTLDIQTIITKDISMEKQTKIAQYISLGVGILSIAVAI
                     VLANGEIKSAYEWFNSFMGLVLGVLAGIFVLGAFCKKATKMGAYVGFIVSAILVVYLK
                     YRMPEVTSWAYSLITITTSVVVGTIVSAIEAKVKAKVSLPKAETTVYYEK"
     gene            35741..36193
                     /locus_tag="KNP36_000764"
     CDS             35741..36193
                     /locus_tag="KNP36_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HBF0872655.1"
                     /translation="MIFGNINHSKTYSTLHEDLLRCFEYAKDNSLIDYEKGTYTIDGD
                     DIFVNIVEYKTCEKEDRFWEAHKKYIDVHLMLDGCERIDINFIENLEQKIYEEKGDFL
                     PLDGKNNGYMELRKGDFLVCYPEDAHMTGIKVLEKENIKKAIFKVLVR"
     gene            36353..37156
                     /locus_tag="KNP36_000765"
     CDS             36353..37156
                     /locus_tag="KNP36_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872656.1"
                     /translation="MENIDVFLLIGQSNARGLGNPKESIIPNENCFEYLSTDEIINMR
                     CELETSEGDGTIAPAFSNEWNKLTGNKVCFIHNAKDGSRIKNWNHDNNWFLNDTIEKF
                     NTGCTTLSKHYNIENKYVIWIQGESDAKYGSDVLYYKESLKKIAYRLKEECMIDKMFV
                     SLTGYWLGEDEYFIRTRRIAAAQESACSECDILCVGSKIAMQFHDRGLTIDDVHYTQE
                     GLNMLGEDLCKNIYKYHITKEKSVLSDTIDLSEARKYICELEKISKRFV"
     gene            37214..38101
                     /locus_tag="KNP36_000766"
     CDS             37214..38101
                     /locus_tag="KNP36_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBF0872657.1"
                     /translation="MKNYVCIDVGGTSIKYGFIREDGFIIDKSSLDTEAKEKGGEGIL
                     AKIKDIVKKYIEENEISGICISTAGMVDPVEGKILFALEELIPNYKGMQLKKEVEKEF
                     NIKCEVENDVNCAGLGEMWLGAGKDATSSICLTIGTGIGGCIIINNKLINGFSNSAGE
                     VGYMNVNGSSFQELASTSSLIKKVAKIKNLNENDLNGKIIFDLAKNNDEDCLKELDNM
                     IKSLAVGIANICYVINPEVVILGGGIMAQEKFLKPKIDKALKEVLIERVYKNTNIEFA
                     KRQNDAGMLGALYNFLNKI"
     gene            38120..38968
                     /locus_tag="KNP36_000767"
     CDS             38120..38968
                     /locus_tag="KNP36_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0872658.1"
                     /translation="MSILEQLESPTFKVTKSDKLLIAYIKENIDDVFYKPISQIAKES
                     NIGEATITRFVKKMNFNGLQDFKVTLAQEISTINKKNIINKNIQNDEPALDTAKKLLS
                     SNVTTLENTVEIINSKDVHDCARLIINAKKVYFIGIGYSGIIAQDSNYKFMRIGLNCV
                     SFDSSHTMIMMSSIMEEGDLIIAISHSGETEEIIKTVKLARANNAKIISITENKNSEL
                     KDISDVHLSYVSGETVLETGSISSKLAQFFIIDLVYTQVVKELSNEAIERKIKTTNAI
                     KLFKNE"
     gene            39031..39720
                     /locus_tag="KNP36_000768"
     CDS             39031..39720
                     /locus_tag="KNP36_000768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBF0872659.1"
                     /translation="MSKLKDYNIDKVIIFNNLSTKTKNQLKEKVKLKRLQKKEILFYE
                     KDSLDSVYILLEGKVSIFKISENGERKVIFILNSGEVINDITLDASKNSTVGCEAFEN
                     SIVAYYSIEEFLEIMQNDFQLTKDIISYMERRIRRLYRQLKNSISIKVDKKLAAKLYR
                     LSREFGVCCGEWTLLNVNITVTYLADMLGCKRETVSRMIKVLQKEELIKIDNKGFYVK
                     ETELSRYFKNN"
     gene            40111..41118
                     /gene="asrA"
                     /locus_tag="KNP36_000769"
     CDS             40111..41118
                     /gene="asrA"
                     /locus_tag="KNP36_000769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrA"
                     /protein_id="HBF0872660.1"
                     /translation="MKLKLDSSKFNEGLNYLKKDYKIFAPVLIPFKGTFSDTDVIRYK
                     EVNAFEEMEFAKKANFSPKEVVLPINQVLFYFTEKEFKESDLDNKKILIFLRACDING
                     IKRLDEIYLNNGEEKDYFYKNIRDKVKFALVGCKESFRNCFCVSMDSNKTDNYSIGLN
                     IEGDTLYLDIKDSEFEVFNGEATEFNVDYVTDNLISVDVPENIDSNEMIGNSIWDEYD
                     TRCIGCGRCNFVCPTCSCFTMQDIFYKENENVGERRRVWASCQVDGYTDIAGGNSFRK
                     KQGERMRFKTMHKIHDFKKRFGYHMCVGCGRCDDACPQYISFSKCIEKINDLVISKEE
                     V"
     gene            41119..41910
                     /gene="asrB"
                     /locus_tag="KNP36_000770"
     CDS             41119..41910
                     /gene="asrB"
                     /locus_tag="KNP36_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrB"
                     /protein_id="HBF0872661.1"
                     /translation="MNPYIPVSAKILDIVKHTDKEWTFRVNCNTKGVLPGKFYEISIP
                     KYGESPISVSGYGEDYIDFTIRNVGKVTSELFNYKEGDSFFIRGPYGNGFDVSLYEGR
                     EIVVVAGGSALAPVRGIVEYFYNNKEKCEKFKLIVGFKSPKDILFADDLKRWSKKLDI
                     LVTVDGAEEGYSGNVGLVTKYIPELDMKDINNTSIVVVGPPMMMKFTVEEFLKRDLDE
                     KNIWVSYERKMCCGIGKCGHCKMDDTYICLDGPVFDYSYAKNLID"
     gene            41923..42894
                     /gene="asrC"
                     /locus_tag="KNP36_000771"
     CDS             41923..42894
                     /gene="asrC"
                     /locus_tag="KNP36_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite reductase subunit C"
                     /protein_id="HBF0872662.1"
                     /translation="MIRDLNTKKVMKNAYRITKTKYETSLRVRVPGGLIDPESLAVVS
                     KIASEYGNGQVHITTRQGFEILGINMEDMEEINKIIQPVIEKMNINQSEKNAGYPAAG
                     TRNIAACIGNKVCPKAQYNTTEFAKRIEKAIFPNDLHFKVALTGCPNDCIKARMNDFG
                     IIGMALPIYEKDRCVNCGACVKKCSKISVGALKTENNKVVRDKDKCIGCGECVLNCPT
                     NAWTRDEKKYYRLAIMGRTGKKNPRLAEDFLLWVDEDSIIKIILNTYRYVEKYIDKDA
                     PGGKEHIGYIIDRTGFMEFKKWALEGVELPEITKMYENIYWSGIKYL"
     gene            42951..43727
                     /locus_tag="KNP36_000772"
     CDS             42951..43727
                     /locus_tag="KNP36_000772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBF0872663.1"
                     /translation="MHKETLDKLTNAAINKINLLNTSKVKYLVSSAFAGLYVGIGILL
                     IFTIGGLLTDAGSPMTKIVMGLSFAIALSLVIMTGTELFTGNNMVMSAGMLNKGVSIK
                     DTSKIWAYSWVGNLIGALVLGIIFVGTGLIDKGPVAEFFANTAASKASMPFTALFFRG
                     ILCNILVCVSVLCSFRTNSDTAKIIMIFLCLFAFITSGFEHSVANMTIYSVSLFSPTI
                     NTVTIGGAIYNLVAVTLGNIVGGALFMGLGTYILGKEKLN"
     gene            43998..46016
                     /locus_tag="KNP36_000773"
     CDS             43998..46016
                     /locus_tag="KNP36_000773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBF0872664.1"
                     /translation="MTKKLVISKTKLFIFIIAFISIFIYLFGSKNTLIGVGIVTAMLT
                     LLERDLTISPIKNLLKYLAINIILGILSFFAVQNMYLGVLLNFIALFIIGYVFSYDLK
                     RAVYVPFGLMYIFMVSIPVGKSEFPMRLSALAVGAVIIMIAQFVMNRNRMKNVGDKEL
                     ISICDELLEKISLLKNTINDDSSIIKSSMRKIDSCNYRINSISKNLKMVIFDNRKDDF
                     YISIRGIDIMNILFSLERISLILERYKKDSKEFEDEDIKNILEESSINSKSDVLVVAT
                     KEINYIKMCLENKDTITDKEILGFRDYVIAQDTKNINLKEIYSVLENLYEFLVDYKKV
                     KSRDEKKAERKSKIPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLR
                     DGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLA
                     GYINSYVVDYRKLMVCVTVSALGSAVVMGDPNVLTISRISYVALGAIIALIVNKFILP
                     YDAKTGYQHVIEMYKGIVKNIIDEVNKSIENVADVYYIKNLLLIPSLIEDRLMLINAI
                     YKDKHQEDFLENQKLLISNMYNLYINVNKNKIKDEDVEKILRDTNYISNYNVDKYDEG
                     RSVILESIINTKSLGDKIICLNLLQTLNGVKEMYRISNITKVSIKEAA"
     gene            46231..47088
                     /locus_tag="KNP36_000774"
     CDS             46231..47088
                     /locus_tag="KNP36_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0872665.1"
                     /translation="MSKDVKVKRNKKYDTFSITMELERPLLYDEVENKDDKNNNRKFN
                     IKNKIFKGIGILFVLILLGFFIWINKTYEPQKLAKEALVSNSKVEVTVNENISFTPKG
                     RKVSKGLILYPGAKVEIESYAPLARKIAESGYEVVIVKMPLNLAILGTNKAQKVMDSY
                     NNIEHWVIGGHSLGGVAASNFARDNKLIEGVVFLASYPMGDELKELGKKVISIWGSKD
                     GVVNFKSLVESKQKLPDDTTYVEIEGGNHAQFGDYGKQKGDNDAIISQEKQLNITANS
                     IIKFLKNIS"
     gene            47185..48054
                     /locus_tag="KNP36_000775"
     CDS             47185..48054
                     /locus_tag="KNP36_000775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0872666.1"
                     /translation="MEYDMPLYRPPSEAYSLIIQVTLGCSHNKCTFCSMYKSKKFKIK
                     PLEVIKNEIDIFRRYYKHVERIFLADGDALIIPMEKLRDIILYIKEVFPECERITMYG
                     SPKSIEKKSDDELKELRKLGVKMIYLGLESGSNEVLEDIKKGFSSEQLIKVGRKVKKS
                     GIKLSATVIAGLGGTKKTHQHAVDTGKMLGAISPDYVGVLSLMVEPNTELYDLLKAGE
                     FTILEDKAVLQEIKEMIKNIDANEKIVFRSNHASNYANLKGVLPDDKQRLIDEIDYYL
                     SNQKLKREEYRRL"
     gene            complement(48424..49056)
                     /locus_tag="KNP36_000776"
     CDS             complement(48424..49056)
                     /locus_tag="KNP36_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="HBF0872667.1"
                     /translation="MTIPSSNKVYPRSNDYQTVYLKNVITRENIEVGDYTIYNDFYND
                     PRDFEKNNVLYHYPINNDKLIIGKFCSIACNAKFLMTSGNHSMKSKSTYTFPIFYEEW
                     KLDINHITDAWDNKGNIIIGNDVWIGYDSIIMSGVNIGDGAIIGTRAVVTNDVPPYSI
                     VGGVPAKIIKKRFNNDTISKLLEIKWWDWPYKKIQSNIKHIQSGNIDKLV"
     gene            complement(49128..49481)
                     /locus_tag="KNP36_000777"
     CDS             complement(49128..49481)
                     /locus_tag="KNP36_000777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase DNA-binding domain-containing protein"
                     /protein_id="HBF0872668.1"
                     /translation="MSTEKRRDNKDRILRTGESQRKDGRYAYKYVYSFGKPQFVYSWK
                     LVPTDKPPKGKRDDISLRDKEKAIQNDLDDSIDTIGKKMTVCQLYAKKNGLRKNIRLN
                     TKKGRHYLMKILNKE"
     gene            complement(49559..49762)
                     /locus_tag="KNP36_000778"
     CDS             complement(49559..49762)
                     /locus_tag="KNP36_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBF0872669.1"
                     /translation="MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKRADENLDSGWVI
                     MNSNRIQIKRKQFEKIVDTLDVI"
     gene            complement(50152..50382)
                     /locus_tag="KNP36_000779"
     CDS             complement(50152..50382)
                     /locus_tag="KNP36_000779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872670.1"
                     /translation="MKPTKEVLPFTIILLAVHGDVNAINVILKHFEHYIIRLSQKTLF
                     DEYGNPYIHVEEETKRMLGTKLITAILRFNLS"
     gene            complement(50384..50791)
                     /locus_tag="KNP36_000780"
     CDS             complement(50384..50791)
                     /locus_tag="KNP36_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0872671.1"
                     /translation="MVDEKTIEHQFDSFCKTVLRNYARDIYDENKRRNDYLVSLESLS
                     LAELSKLSILDDYDSNYICMVSYDYNIRIEDVLMAQAIGKLTKRKQDIILLSFFFNMT
                     NADIATLMDLAENTIHYHKTNALKELKELMQEH"
     gene            complement(51151..51600)
                     /locus_tag="KNP36_000781"
                     /pseudo
     CDS             complement(51151..51600)
                     /locus_tag="KNP36_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729090.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            complement(51614..52540)
                     /locus_tag="KNP36_000782"
     CDS             complement(51614..52540)
                     /locus_tag="KNP36_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872672.1"
                     /translation="MSDILSRITNKIGDKNIVDKLSALSKSDLNSLLLEVFDRQANTL
                     TATDILKSYQLNRFTIPSGIDPEEIHALESKLLRKAFNMDIKTIMLSPSAPLGSCSVF
                     GSVDQYNVVSALRGTETLADPSNMLAIIIADKLKRKEENNTIPIHMATTARVIRAQNF
                     VGKGLYSHFGLYCMVSSGIDTGSYTCEKMLLEKHLNYYKDILSEIENVRFSIILRKRN
                     GYKDNDGFFDRMVETIKLIFPNIELSIHNDDVDNNYYKGINFKLSVKQGNETVEIVDG
                     GFVDWTYQMLGNKRERCLISGIGLERFLVAVS"
     gene            complement(52665..53447)
                     /locus_tag="KNP36_000783"
     CDS             complement(52665..53447)
                     /locus_tag="KNP36_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /protein_id="HBF0872673.1"
                     /translation="MTKTQQKMIQNVLEFSKRDSRIIGLAISSSYITKSLDEYSDLDF
                     LIVADDKSYEEVIEERLLIVEQFGTLVSAFTGEHVGEPRLIISLYDSPVLHVDFKFTT
                     LDGLLDRVEDSAILYEENNCITEIYSKKEAYFPTPDLQWIEDRFWIWVHYACTKIGRR
                     ELFETIDFLSFLRQSVLAPLIQLLLGKLPRGVRKIELDAPQYIEALEKTVANHEYKSC
                     VNALQATINLYLELREELSQSPIVRKVEAERVALQYFQDLIK"
     gene            complement(53603..54223)
                     /locus_tag="KNP36_000784"
     CDS             complement(53603..54223)
                     /locus_tag="KNP36_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBF0872674.1"
                     /translation="MHLIDFMNEDIKKKLVKKTYKKKETILFAEQENEYVILMIDGIA
                     EAFILNVKGNISTIHLYRSGSFFGEMEQFNDGKKPVEIVAFTDCNVYKLHRDDFLNWL
                     RGDFEATKFLIREISSKLVVNAELIEELSSLSVKERLLRCISLHYYRSELNLLTKKQL
                     ASEVNAPIRSINRAINECVQEHLIAYENKRFSVINQREVLKNLPTT"
     gene            complement(54311..55009)
                     /locus_tag="KNP36_000785"
     CDS             complement(54311..55009)
                     /locus_tag="KNP36_000785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872675.1"
                     /translation="MYKLSYVVRVSTKNLDELKRRCDEVKDFYDDLSIKLVRPFGDML
                     GLHGEFIPVSKRYINDYIQYVTSDFLAGLGFGATQTLGEHEDIYLGYNLDTGKNVYLK
                     PALASQGVKGSITNALASAFIGSLGGGKLFSNNMLVYYAVLFGGQAVIVDPKAERGKW
                     KETLPEIAHEINIVNLTSNDENKGLLDPYVILSRKKDSESLAIDILTFLTGISSRDSD
                     KFLQKNDNWKIIME"
     gene            55110..55925
                     /locus_tag="KNP36_000786"
                     /pseudo
     CDS             55110..55925
                     /locus_tag="KNP36_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897377.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            56597..57364
                     /locus_tag="KNP36_000787"
     CDS             56597..57364
                     /locus_tag="KNP36_000787"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HBF0872676.1"
                     /translation="MKRKVQVKNITIGEGRPKICVPIIGKNKKDIIKEAKELKDACLD
                     IIEWRVDFFENVENIKEVKEVLYELRSYIHDIPLLFTFRSVVEGGEKLISRDYYTTLN
                     KEISNTGLVDLIDVELFMGDEVIDEVVNFAHKKEVKVIISNHDFNKTPKKEEIVSRLC
                     RMQELGADLPKIAVMPQNEKDVLVLLEATNEMFKIYADRPIITMSMSGMGVISRLCGE
                     IFGSALTFGAAKSVSAPGQISFKELNSVLNLLHKSIN"
     gene            complement(57692..58369)
                     /locus_tag="KNP36_000788"
     CDS             complement(57692..58369)
                     /locus_tag="KNP36_000788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872677.1"
                     /translation="MIVIEGSDKFKIAKEYIDVEYTLFSKVTFRYEKLKFKDNAELEK
                     IKMFKYKNGYIPNKLNLSFGYGFSSYKKQIIRETVDTLRLTEIFSSENIEDIKFIKDG
                     TKKLEISIEKVVKFKRRKKRNYVCCYCPDMYRDIKLDKESINKIYNRKIKIEREVNIF
                     EDEDVIINKKVLKFPKSWTKNMQKYWLSENKYPIHSTVIDDDRYKCCNVQYTKNRVII
                     LYYIYNH"
     gene            complement(58519..58836)
                     /locus_tag="KNP36_000789"
     CDS             complement(58519..58836)
                     /locus_tag="KNP36_000789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872678.1"
                     /translation="MNYIGKRLKEERKKANLTSKEFANMVGVSPWYITQIESGKKNPS
                     LKTFIKFVNILNISADVLIKDITSTGKTYLENDINEELKDLNSRELNLISQIIDIIKK
                     NKI"
     gene            complement(58858..59196)
                     /locus_tag="KNP36_000790"
     CDS             complement(58858..59196)
                     /locus_tag="KNP36_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872679.1"
                     /translation="MANIGKIIGDRIKVYRTKLGYSQEFLAEKAGLHPTYIGQIERAE
                     TNTSINIIMKIATALDIPLELLFANIITTEGVDNSVPLECYEMINKLTEKEQIAMLEL
                     IKCIIKYKEI"
BASE COUNT        22936 a         6917 c         9895 g        19778 t
ORIGIN      
        1 atttaattaa tcatgttgag tttcaaggtc tatatgatta attaaatcca tttttgttat
       61 ttataattat tattgaatat atttttacat ataagatata aggtgataga tagaaattgt
      121 tggattatgt aaataattaa tatataatac cattatgggc aataaataca aatcaaatga
      181 taatatagtc tatttatgta aatgttatat tgtatcctaa gtataatagt aagttttttg
      241 atagtggtgt agaaagtaaa aatctactag cctaaattga tgtatggatt agtttaggaa
      301 cagtaattgc atatcttaag tttgatgtca tgttgggcta ctagaaatag gtcatctttt
      361 tcacttgaat atcttttctt taaacatggg gagtatcata tcaaaaacat atgaaaatta
      421 agtgatttat gagaacagta atattttata tgatagtata gaatagtaat aaagtattag
      481 gaggaacatt gagtgttaaa aaagtggttt ggtattgtga aaaaaagaca aaaaagtgag
      541 tcagtaaaag aagaaggtga agtaatatta aaaaacgaaa aaatattatc tgaagaaaag
      601 ttgatagatg aagaaggagt tgtagttaat attgataatc aaatattaac taaagtagta
      661 aatgatgaca atgaaataga agaaaaaata atagaagaag atttgttaat tagtgaaaat
      721 accataaaat tagatgataa agaagcaatt attaatgata aaaacataga attatgtaaa
      781 aaagaagttc aagttgaaag tgaaaaaata ggtttaaata agtttgaagg actggaccaa
      841 aatgaaaatt ataatctaga aaaaaatgtt attgaagaaa aaaaagtaag tgaatgtttg
      901 acagaagaag atttagagta cataaaagaa attaaaataa aaagaggaaa aagtataaaa
      961 gctataaact tgtatactaa agaagagtgg gtttttgaca ctcatataca gtgtagtaaa
     1021 aaactcaaag ttccattagg gtacataaga gaaaatttaa aatatggata tatggattac
     1081 tttggagatg caataaatta tttaagtgaa gtattaaata tagatgaata ctgcaaaagt
     1141 gaatggagct atctcgataa tagcaaatct ccatctgaga tatttaatat tctaaacaat
     1201 aaaatattta gtataaggct ttctaatgaa aaaagaaatg aaattttgac aaatgataaa
     1261 attgaagcat taaaaatgaa ttatagattt gaatgtattg atgaagaata tgatgaatat
     1321 tttaaaaaat ataagtctat aatcaaaaga ggtggaaaga aaaaagttga attagtaaat
     1381 aaaaaaggtg acattttaga aatatttaag tctttagaag aatgtgccat ttatttgcaa
     1441 aaggaaaaga atgaagttat acaaatgtta aaatatggag atacaaaagt aggaagaaac
     1501 tttataaggt atagtttgag aagtatttaa tttcatttta aattcataag agtttcattt
     1561 ctgattcaca catttaatat tattttaatg taaaataata aaggtgaagt attgcacaat
     1621 taaaattaag gagggtatta atgtctgaag aaaaaaatcc aaaagaaaat acattagatg
     1681 aatctaaaaa ttcagataat gtaaattcta aaaaagatga tgtgtcagat gaaaaaaata
     1741 ctgataacaa agttaaaaaa agggaaataa agctaaacaa caaaacactt aaagctattg
     1801 tagcaattgt tgcagtagga gctatatgtt taggtggagg ctatgttttt ggcaaagaag
     1861 ctggaagaaa attgcctgct acttcaaaac actataatag cagtgaggta gtagctacta
     1921 ttggggataa aaaaataaca ggtgaaatgt taagaaagag aatggagcca ttattttatt
     1981 taaatgcaaa aactactatg actgatgacg aaatacgttc atatgaatca aatatgattg
     2041 aaactatgat tacatctgat atattatcct ctgaagcagc aaaagagaaa ataagtataa
     2101 ctaatgacca actagatgct cagtataata atttaatgag tagtatagaa tcagcaatgg
     2161 gaatgactaa agaagagttt ttaaaacagt ttgatttgac tgaaaaatat ataaaagatg
     2221 atatgaaaaa agagctagta gcatcaaaat atttaaatga aaaatcaaaa gttactgata
     2281 aagaagcaga gaactattac aataaaaaca agagcaatta tttacaagtt agagcttcac
     2341 atattttaat aaaaactgtt gatgataaag gtaagcaagt tagtagtagc aaaaaagctg
     2401 aacttaagaa agaagctgaa gaaatactta aaaaagccca agctggggaa gattttgcta
     2461 ctctagctaa aaaatactct gaagatagta gtgcagaatc aggtggagat ttaggtttct
     2521 ttggtaaagg tcagatggtg gaatcttttg aaaaagcagc ctttgcattg aagaagggag
     2581 aggtatctaa caaacttgta gaaagtgatt atggatatca tataattaag aaaactgatg
     2641 aaaaatatca gccatttgaa gaggtaaaat cagatttagt aagcagttta acatcagaaa
     2701 aacaaaacct acttatacaa aatctaaaag aaaaatataa tgttaaaatt acagataaat
     2761 atcaaatgaa agctaaagaa tagataaagt caatttatta aaaaaaagaa aaattaactg
     2821 tatggataaa agctattttt actctcaata tagagagtat aaaatagctt ttattatttt
     2881 gcaataaaat ctatttatat atatgaagtg ataaagaaat aacatgcaaa aaggtattaa
     2941 aaagaaatat ttttaatttg aattttttca ataaaaattt acaaaaatga aaaaataaac
     3001 aaaaaagaat tgaagattta agttgttatt taaatatata tatattaaga ttttctgctg
     3061 aagatactaa aaaaataata tttttcataa ttttaaaaat aataataaaa aaatgaaaat
     3121 acaggctata atctattgag taaacataga aaagatgata ttataagtat gtgctaaaat
     3181 ggttaaagca atattaatat taaatttaac tataaaacaa aagggggcgt ttttttatgt
     3241 caagtacaga aagcgtatct aaaaaaagtg gtcatccgaa gagtttttgg cttatttgca
     3301 tgacaatttt gtgggaaaga tttagttatt atggtttaac agctttattg gtattatttt
     3361 ttacagcaag tgtagctcaa ggtggtttag gtctttctac tcaagaagca acatctatgt
     3421 ttggcttatt tacaggtctt atatatctta caccattagt cggtggctgg ttagcagata
     3481 aagttttagg tcaacaaaaa tgtatttcta taggtgcact tttaatagca ataggagatt
     3541 tcgtactatt tgcttcatct acatctattg caatggtttg ggtaggtcta tcaataatta
     3601 ttttaggaaa tggttttttt aaatcaagtt gctcaaatat agttggggat atatatccta
     3661 aaactgatgt gtcaagaaaa gatgcagcat acagtttatt ctatatggca gtaaatgtag
     3721 gagcatttat agctccaata atatgtggat tgctttctga taatgtattt gcagtaagag
     3781 gagcaagtgg agatatagta tcttatggat ataagatggc atttttaatt tgtggtatag
     3841 gcatgatgtt aggtatgatt atatttacac ttcttgcacc aaaattatta aatgaagtcg
     3901 gaaaatatcc tgtgactaaa ggtaataaag gtgaaaaaat tgagtatgga ccacttacta
     3961 agttggagaa aaataggata atagcaatgg ttattttatt tttatttgtg gtcttattct
     4021 ggacagcata ctatcaaaca caaagttctt ttatgattta tgtaagggat aatgtaaata
     4081 gaactctatt tggatttgaa atgccagtag catggcttac atcactaaat gctatattat
     4141 gtgtggcttt atgcccagta ttagctaccc tatgggttaa attatctcat accaaaagag
     4201 gtgatttctc tattccagtt aaaatgggat taggaatgat aataatgggt gttgggttta
     4261 tagttatggt atttgctaca ttagctaatg gtccagatgg aatggtaaag gctagtatat
     4321 tgtttatagt attgacttat atatttacaa cagtaggtga attattctta tctcctatag
     4381 gacttgcaat gttcaataaa ttagctccag ctaagtatgc tacgttgtct atgggagcct
     4441 ggtatctaac aagttttttt gcaagtttat tatcaggaaa gattgctggt tttacagcca
     4501 cacttggttt tttacagata tttggaggaa tagcaacagt tttaataata tttggtttaa
     4561 tattattggg aataagaaat gtattaacaa gattaatggc tatggattta ctaacaaaag
     4621 aaaaataatt catgacgaat tattgtaaat aaatgaatta ctttaaataa aggaagttac
     4681 atttaaatat aaaattaaat gtaatttcct ctttgattat gaaaaaaagc tttacacaaa
     4741 tagatattat aattaaaatt ataattgtga taattagagt gtataagatt tatataaatt
     4801 atacaaaaaa tatttatgta ataaacttta catacttata tatttagtta ttcaaactat
     4861 tatttcgagg aggtcttgtt gtgaatataa aagatagatt aagtggatta agaaaattta
     4921 tggaagaaaa aaatatagat gcctatatga ttccatcttc tgataatcac caaagtgaat
     4981 atgtaggaga ttacttcaaa tcaagagaat ttatatcagg gtttaatggt tcagcaggga
     5041 cggttattgt gactaaagac gaagctgggt tatggacaga tggaagatat tttatacagg
     5101 cagaatctca attagaagga agtacaataa aattattcaa aatgggacaa gaaggttgcc
     5161 caactacaga tgaatattta tataaaaata ttcctgaagg aggaacttta ggatttgatg
     5221 gtagagttat atctgctaga gaaggagcta cattagctga aaaattatct aaaaaaggta
     5281 taaagataga atatcagtat gatttaatag atagtatatg gccagataga cctgctttat
     5341 cagatagtaa agcattttta ttagatgtta aatattgtgg agaaagtttt agctcaaaat
     5401 tagctagatt aagagaaaaa atgagtgaaa aaggtacttc tactcatgta ataactactc
     5461 ttgatgatat agcatggtta ttcaatataa gaggtggaga tgttaaatat aatccagttg
     5521 tactttctta tgcagtaata actttaaaag aagtttatct atttgttgat gaaagtaagt
     5581 taaatgaaga aatactaaat gaactagcta aggaaaatgt tcaaataaag ccatataatg
     5641 atgtgtatga atttgtaaaa aatatagaca aaactgaaaa agttttatta gatggaacta
     5701 agcttagtta tacaatttac aataatatac cttgtgaagt tgagaaagtt gatgagttca
     5761 atccagtaat gttttttaaa gctcaaaaaa atgaggtaga attagaaaat ataagaaatt
     5821 cacatgtaaa agatggtgta gctttcacta aatttatgta ctggttaaag aaaaatgtag
     5881 gtaagatgga aatcactgaa ataagtgcta ctcaaaaatt agaggactta agaagagagc
     5941 aagaaggttt ctttgagcca agtttcaata caattgctgc atataaagag catgctgcaa
     6001 tgatgcacta tagtgcaact ccagagtcaa attataaatt agaggcagaa ggattatttt
     6061 tagtagattc aggtggacaa tattatgatg gaactactga tataactagg actacagttt
     6121 taggacctat aagtgatgaa ttaaaactac actttacttc tgtagcaaga ggaatgataa
     6181 atctttctaa ggctaagttc ttgcatggtt gtagaggata taacttagac atactatcta
     6241 gaagttgcat gtggaatatg ggaattgatt atcaatgtgg aactggacat ggtataggat
     6301 ttgtgctaaa tgttcacgaa gctccaaatg gatttagatg gagagtagta cctgaaagat
     6361 ttgatagtgc agttcttgaa gaaggaatgg taactactaa tgaaccaggt atatatatag
     6421 aaggttctca tggtataaga acagagaatg aaattgtagt tagaaaagct gaaaagaatt
     6481 tctatggtca atttatggaa tttgaagttg ttacgttagc tcctattgac ttagatggta
     6541 tagcaccaga attaatgaat aaggatgaaa aagattattt aaattggtat cataagttag
     6601 tttatgataa aatatcacct ttcttaactg atgaagaaag agaatggtta aaagtttaca
     6661 ctagagctat atagtttgta ctagatacaa taaaaatcga ggtattataa tgcctcgatt
     6721 ttttattgta tattttatta actttaaaaa atttttaatt tgataattct actaattttt
     6781 tattcattat aagtagtata attccaaata tcaataaaaa tgatggtatc actatgaaga
     6841 cttgtaacat accaagttgg tctataatag cttgcgtata gccagataat ttatttgctg
     6901 caaatttgcc taaaaaccaa acacccatta ggaatgaaat atacttttca ggcgaaagtt
     6961 tatttaccat accatacccg actggagaaa agcaaatttc tcctatactt tggaatgtta
     7021 aaaatccaac tacccaaaat acacttgctt tgtgaattga attagggtct gttcctgttt
     7081 gtataactgc tactatcata aacaaaaatg ctatggctaa tagtataaaa cctaagctca
     7141 ttttttttgg cacacttaaa tcgccttttt tagtttgaga taattttacc catactaaag
     7201 cagagatagg tccaagaata acacaaagga gaccattgta tgaatctatc catgaagtag
     7261 gaatttgaaa attgccaaca gtaagattta tgtgttcctt tgtatagagt gcaatagaca
     7321 tagaggcttg gttatatgct atccaaaaaa atactgtgaa aaaagctaac accaatatta
     7381 ctattattct ttttttctca atcaaagtta aaggtcttga agcgagcatt ttcttatatt
     7441 ctagtgattt tcttatagac tctctcccgt taatagggtc attattcaaa ggtttataaa
     7501 actttctgtt tccaaatata aagaagaata aacctattag aaccgtaatt gatgaaaata
     7561 aaaatacata tctatatcca tacatactta tagataatcc gcttttcata gcaaaccatt
     7621 cattagcaac taaaccgcat attaaagggc caaataaagt acctagatta gtagccatat
     7681 acgtaataga gaaagctcca tcttttcttg ggtcatcatt ggtatataag tttccaacca
     7741 tagtatgtaa gtttccttta taaaaaccta ttcctaatcc agataaaaat atcatgatgt
     7801 ttatatccat cttactattt gctatgtatc ctagaaaata accaattgaa accattagca
     7861 ttccaagtat aatacagttt ttgggaccta aaaatctatc actgacccat ccaccaataa
     7921 ctggagagaa ataagtccat gctaaaaaag atgcaagcat tgatgcggat tctgctggtg
     7981 ttaaccctaa accacctttg gagacttgtt cagctaaaaa caataataat accaatttca
     8041 taccatagta tgcaagtcct acaaaggtaa atattgaaca gcagaaatat aaatctctag
     8101 gttgtttaag tttttcttgc gtttttaaaa ctgacatatg tcgagaacct ccagataaat
     8161 agtttaacaa aattttacca tactatatga gtatatgttt ttttcatata gacgtcaact
     8221 tgtaagataa tttaattaag tcgaaatata tgtaaaaata gtatcatttt tgtgtattca
     8281 gtaatatttt tttatgataa tatatgttat tattatatta aaatacaaac atatttatgg
     8341 aaaggatatg ccaatttagt agttagattg attgtttggc aggtgggatg agctatgata
     8401 agaaagaaat ctgaattaca agtagaagta aaagaaaatt taaatggtgg tataggaaag
     8461 gttaagcttg aaaacataat acaaaatgaa gagcttaaag gaaaaggaag actatttaaa
     8521 agagtagctt taccagtagg aagttcaatt ggtgtgcatg accatacaac agattttgaa
     8581 gtatattata tactaaaggg aaaaggtaaa gtatttgata atggggaatt tgtagaagta
     8641 aatgagggtg atgtagtgta tacagctgat ggcgaaaaac attctataga aaatatagga
     8701 gaagaagatc ttgagtttgt agcactagtt ttatatatgt aaaatatgga ggaggagtca
     8761 tgacaggcaa gatagaagaa attaaggaca agataaatag attttgcaac tccaatttaa
     8821 atcaagaata caaagatata agctttaaaa ttttgcaaaa ccttttagat aataataaag
     8881 agataattca ttcttctaga gctgatatat ggtcttcagc tatactaaat atagttttag
     8941 aacaaaatct tttatacaat aagaagcatc cactacatat aacaaaaaaa gagttttcaa
     9001 aacaaatagg tgtttcttta aatactataa ataataaatc gtctttaata aaagatgttt
     9061 gtagtattga ctttttaaat caagatacta tagctatttc taatgtagaa ttttgggtaa
     9121 aagagactaa ttccaaatca aagtctgtag atttagattt agaaaagaag aaaatactat
     9181 ataaaagata tattaagcta tcacaagatg cgaatagtga tattgaatca attagatata
     9241 tggaggaagc tgtaaatata ggtaaaagta tgattactaa agaagataaa gaacttggat
     9301 tttggaaagg tttatctacc agagcctata tgatagcact tgaatccctt gctagaaagt
     9361 tagaaagtat taataatcta aaggagtcca aaaaagtatt agaatattta atagaaatta
     9421 atcctagtga tgagcaggga ataagataca aattattaaa tgtattaatt agattaaatg
     9481 atagaacttc aataaataaa ttatttgaac tttataaaga agaaaaatct gctacatgga
     9541 tgtacagtaa agctctttat tactttaaaa ataaaagtat gtttttggca aatgattcta
     9601 ttaaggttgc tagaagtaaa aataagtacg ttggattata tttgttagat tggcgaaatg
     9661 cttttggtag agaatttgtt acagaggaag aaaaggcaga agctgtctat tactatgatg
     9721 aaaacatagt gatttggaat gaagttaaag gttctatgga ttggctatta aaaaaaatgt
     9781 tggaattttc ataaaaaaaa ctactcctta cttttatata agtcaaagga gtagttttta
     9841 atttatacat ctagttttaa atcttcaggt tttattagac ctttttttct cataaattct
     9901 gaaatcaaca aagttacaat agcaggaagt ataaaattaa gtaaaagtat accaacccac
     9961 atagatatac ctccttttcc agcactttgc atagcagtta ctgttccaaa ttgtccaacc
    10021 aatccacaag tacccatacc agaaccaata ggaatattct ccattttgaa tattgttgta
    10081 gataatggtc caagtaatat tgaagctaca gtaggtggta tccaaatttt ccaatttttt
    10141 attatattag gtacttgcaa catagatgtc ccaagacctt gtgccacaag gccaccaact
    10201 ccattttctc taaagctcat aacagcaaag cctaccattt ggcaacaaca acctacagtt
    10261 gctgcaccac cagcaagacc acctaaactt aacatcatac aaatagctgc actacttata
    10321 ggtaatgtaa gagctattcc aacaagtgca gagactaaag ctcccattat tataggttgc
    10381 atagttgtag cttgcattat tatatttcca aatgaagtca taaaagcaga aacagctgga
    10441 ccaataagtt cagctacaag tactccaatt agtattgtta cagcaggtgt aaccaatata
    10501 tctatttttg tttcttttga aactaatttt ccaacctcta cagcaaaaag tgtagcgaca
    10561 aatgctccaa caggtcctcc taattcatta ccacaagctc caacaagtgc acaagaaaat
    10621 agtacaagtg gaggtgcttg aagtccatac gcaatagcca ctgctatagc tggaccagta
    10681 acctgtttag caagagggct tataacttca gtaaaaagag aaatattgaa attatctcct
    10741 aatgtattga aaattgttcc aattaaaagg gacgaaaaaa gaccgagtgc catataactt
    10801 agtgcgtcaa taagatacct ttgaacagaa atttcaatat tttttctttt agcaaatgat
    10861 ttgaaatttc tttttttata attgatttcc aatttaaaat cctcctcata taatataagt
    10921 ataatttctt tttaattaat tatataactt ttcagctgac aagacaaatg ttatttcact
    10981 aaaattagac tattgtaata gtaagaaatt aacattaatt ttagttttaa attttaaatt
    11041 tatggtttat aattagtata gggatattct gaaatataat aattttccag tttatcccaa
    11101 tatttaactt aggtagattg cttacaaaac aaatgattat atattaggct aaaaggaagt
    11161 ggatagatga tatttgtaaa aaataagaaa tacagaaaaa ttgccataat tatatctatt
    11221 cctatattgc ttgttgcgca gtactacctt tttaaatttg gaatacttag accaatggta
    11281 aagggagtag aaattgaaat tgtagatggg gaatatgtta aagatataga taaatatgta
    11341 gtaaaattaa atgaaacagt tactttgtct acaggtgaat atattaaggt tccttcgtat
    11401 gctaaaaatc caaatatttg gtttaatgta ttggataact cagggacttt aaaaatagat
    11461 ggaaataaaa tgacagcatt aaaggttggg tattcttctg tgggtatcat gaaaaattca
    11521 agagtattaa aaaaggctac tataaaagta gtagacccag aggtagaatc actagatatg
    11581 gagattaatg gggatttaaa acatgttggt gatagtgcta ctatagaaag tacaatagaa
    11641 gttgattatg ataagtttaa aaaatcatat aagccagttt ataagagtag caatgaaaat
    11701 attttaaaaa tcaaaggaaa taaagtaagt gcagttggag ttggtaaagc tacaatatat
    11761 gctaagtgtg gaaataaaga aattgagaga acatttagga ttcaagctag agttgctgaa
    11821 ataaatatgg atgatataaa aatagaagtt gaccagaatg aaaaattgaa accagatata
    11881 ataacttctc cgcctggttt agaaccacca aaaatatatt atgagttagt agattcaaaa
    11941 ttacctgtag aaagagcaat aagtttaagt agtaatggaa atgttgtagg gcttagagaa
    12001 ggtaaagata gggtgagaat aacttgtgga gataaatcta aagtaataac agtaacagta
    12061 gtcaaagaaa ctataacgaa tgactatata caaaacttgg ttggttcaca taaaatagta
    12121 aacaataaag ttattattaa acttgaatgg gattatatga aagatgtctt tgattatgat
    12181 atatatctta aagataagtt gtcaggagaa tcatttaaga aaattaaatc tataactata
    12241 aatgaaagtg atttaggtaa gtctaacaag gtatatgcaa ctatagaagt agatatgaag
    12301 ggtaatcaaa atatagattt tgatatttat gtcataggga aaaaggattc agatacaact
    12361 aagccaagta atgtaataaa tattaccaat ggaaatggaa attcaaataa tgataataat
    12421 attaaagata tgagggtaga aaatatatca gctaatgttg atagagataa taatgtcatt
    12481 agagttaact ggagtagtat atctcataag gactgtactt acagtatata tgtaaaaaat
    12541 aatactaatg gagatggaga atttactcta tatcaaagtg atatacaggg aaatgagcat
    12601 actataagta ttcctgaagg agatttaaat ctagatattt atgttgttgc aaattataat
    12661 ggaaatagct ctcaaaatag tgatgttata aatgtaagat agatttgtat acaaattgaa
    12721 agtgttgagt ttatttaaat attaaattaa gaaaaaggat agtatagggt aattatacta
    12781 tccttttttg ttacaatata taggtttaaa atctctagta atataaatta taaaaagtct
    12841 tatttacaca aatctataga tatttttttt attaatcaat attgtcttaa attgaactta
    12901 gtgcggcttc tattgcatgt attactgtcg tatcaaatag tggaatagaa gtgtcatttt
    12961 gtttaattaa aagacctatt tctgtacatc ctaatataac agcctctgca ccttgtttgc
    13021 caagcttatc tataatagat aagaaagctt tttttgaaga ttcagatata attcctaagc
    13081 aaagttcatt aaatattgtg tcatttacta ttatacggtc ttcttcattt ggaattaaga
    13141 cttcaattcc attattaata attacatttt tataaaaatc ttgttccatt gtatatttag
    13201 tacctaataa ggccactttt tttatttctt tttcccttaa taccgtagca gttacatctg
    13261 ctatgtgaag taatggaata tgtatacttt cttgtatttt atctgatacc ttatgcatag
    13321 tattagtaca gataacaata aaatctgccc ctgcctcttg taatttaatt gcagcatcag
    13381 ctaaaatttt ggcgcttttt tcccaatttc cactagattg gcattcttca atttcttgaa
    13441 aatctacact gtaaagtata catttagaag agtgtagtcc acctaatctt tcttttatta
    13501 ctgtattaat aacttgataa tatgtaatgg tactttccca actcatacca ccaattaagc
    13561 ctatagtctt catattatac ctctcttatt tatttatttt gaaatagcta tttacaaata
    13621 caagtatagc atctaaaata gaagcataca atgataaaat tgtatggagt acaattataa
    13681 ttaagaggag taattatatg ccaataaatt cttttgaaaa ctatcctatg acatggaaac
    13741 caaaattaga taaccgaaaa ccaccaatat ataaaacttt agcaatgtta ttagaagaag
    13801 atattaaaag aggaaattta aatcctggag ataaactgcc tccacaacgg gaattagcag
    13861 attttctaga tttaaactta agtacaataa cacgagcatt taaactttgc gaagaaaagg
    13921 gactaatatg tgcaaaagtg ggaaagggaa cattcatttc ttctgatgta aatgtaagta
    13981 atacattatt atatcaaacg gaatcaaaag acataattga attagggaca gttcatcctc
    14041 cgtatgagca aaatacatat attattgact ttattaaaaa tgtactaaaa caaccagaaa
    14101 tggataggtt tttacaatac atgtctccat ctggcacata tatgcaaaaa aagtcaattg
    14161 caaaatggat agaaagaaat aatgtataca ccagtgaaga aaatatatta ttatctacag
    14221 gagggcaaaa tgctatatgt gcaactttac taggattatt taaagctggt gatagaattg
    14281 ctacagattc tttaagtttt tctggaatta agtcaatagc taaaatgata ggtattcaat
    14341 tagtcccaat tcctcaagaa aataatgaaa tatcgattga atatcttgaa agttattgta
    14401 aaaatgaaaa tataaaaggc atatatctta taccagatta tcataatcca acgacacata
    14461 ctatgtctga tttatctcgt aaaaagatag ccaagatagc aaagcaatat aatataataa
    14521 ttattgaaga tgctataaat agcattttta gagatggtat acaaactccc atattttctt
    14581 tagctagtga taatactata tatattttta gtacatctaa atttttatgt gctggtctta
    14641 gagtagcatt tgtagttgct ccaaaacgat atatagaaaa tttagaaaat gcactatata
    14701 atatgaatct aatggtttct ccatttacag cagaaatagt acaccgttta ttatattctc
    14761 ctattataga taaaattata gaagagaaaa gagatgcaat tatagaaaga aatgaagttg
    14821 ctgataaagt tttgtcagat tataatttga ttggtgataa gaattgcagt tttcgttggt
    14881 tacttcttcc tgatgaattg gatggaaaat catttgaaat ttctgcaaaa aatctaggag
    14941 ttcaagtata ttgtgctgaa cgattttcag taggaaactc tacagttcca aaagcagttc
    15001 gtatttgtgt aacagctcca aaagatgtag aagaattaga aaaagggctt aatataataa
    15061 agtcacttct taagagttaa atttatttta ctattattta attaaataaa taaaaaggcg
    15121 gagaaattta ttataataaa cctccgcttt tattatttaa tgaaatactt tactttttat
    15181 taaaaaattt aattttaata atcttgaaaa tataatcgtt ttatggtaaa ataattctta
    15241 aaaatagaaa aaattaatca tttgttaaaa aaaatgcata atttattgta atttattgac
    15301 gaaggttgaa aaatattcat aaatgtgcga aataacagaa aaaatgcaaa aattaattca
    15361 atttcatttg ttataaaatc tatatggcaa aattaaatct gcctatcaga atgatataaa
    15421 cacaccagaa aggaggacgc tatcaaataa tacaagtagt taactttgat agcaaaaaat
    15481 tatgaatgaa caaactagaa tatccttaga gagagctgct gaattaaaat caaaaattga
    15541 tgattatatt caggctagaa aaacgattaa cagaggtctt gaaaaagaag aagagataaa
    15601 taaacgaaaa cagaaaatat taagtatctt aaatggaact gaagaggatt ggaataacta
    15661 caaatggcaa ttatcaaata gaataacaga tgtagatact ttatcaaaaa ttataactct
    15721 aactaaaaaa gaaaaagaat atataaaaga ggttggtact caatttagat gggcaatatc
    15781 tccatattat ttgagtctta tagacccaga agatacatgt gacccaataa aattactgtc
    15841 tataccaaca catatagagt tggaagatga acaagaagat ttggacccaa tgggagaaga
    15901 gtatacaaac ccagcaggat gtataactag aagatacccg gatagattaa taataaatgt
    15961 aacaaatgag tgtgctatgt attgtagaca ctgtcagaga agaagaaata ttggacaaca
    16021 agattctcat aagtcaaaag ctattatcca agaatctata gactatatca gagaaaatga
    16081 agaaataaga gatgtactag taactggtgg agatgctctt acattaaaag atgattattt
    16141 agagtggatt cttagccaac ttaaagagat accacatgtt gattatgtta gattaggtac
    16201 taggactctt gttacaatgc cacaaagaat cacagatgaa ttttgcaata tgctaaaaaa
    16261 atatcaccct gtatatataa atactcattt taatcatcca atggaaataa ctaaggaatc
    16321 taaagaagct tgtgaaaagt tagcaaatgc aggagttcca ttaggaaatc aggcagtatt
    16381 attaaatgga ataaataatg ataaatttgt aatgagatgt ttaaatcaag aattactgaa
    16441 aataagagta aaaccttatt atatattcca aagtaaacat gtaaagggaa caaaacattt
    16501 caatacatca gtagatgatg gtcttgaaat catggagtat ttaagaggat atacatcagg
    16561 aatggctata ccaacatata tagtaaatgc tccaaaagga ggcggaaaga ctcctttgct
    16621 tcctcaatac cttgtatcaa aaggaacaga ttacgttatg cttagaacat gggaaggaaa
    16681 agttataaaa atggaagatg aacctgctgt agatataaag aaacttataa aagaacaagc
    16741 gcaggattaa aaaagtattt aaagtttata aaaagaaaca actttaaaat aaaaagaaaa
    16801 tggatgtcaa atttatatca atttgcatcc attttttatt agttatttat tattttgttg
    16861 ttgattaact aattcaagat atccacttgg gtggaagtaa tatatctcag aagtattttc
    16921 atttacaaag taaccaatat caccatctgc atctggtaaa aatacataac cattaagatt
    16981 tttagctttt aatgcttcaa aatcactagc atttccttga tatatgtaat caacttcatt
    17041 gttgtatttt actaaaagtt ctttagcttg ttcttgagtc aatttagtat tttggcttac
    17101 aggaacattc ttttgagaat ctgcataaga agattcattt actggtgcag ttaataacaa
    17161 acaagataaa actaataaag atataagtgc ttttttcata ctaaaaccct ctttcatgtt
    17221 taattatata agattcatta cttaataata ttgtatgttt cctataatta aatattacca
    17281 ttaaagagaa taatattaca gttacacagc tgtaactttt gattacaaaa tcgtaattaa
    17341 attgtatttt tattccattt gtattttatc atgtctacga tttacaaact cacagaagta
    17401 tatctttata acgcccatca caggagcaga tagaatcata ccaggtatac caaagaatcc
    17461 tccaccaaca gtaactgcta ggattgtaaa gaatgggcta agacctagtt gtccacctac
    17521 gatttttggc tctataaatg taacttcaac ttgttgaatt attattaagt aaattaaaga
    17581 agttaaagca attgttggat tggagaataa attaattatt acaactggtg ccatacctat
    17641 tactggacca aaatatggaa ccatattcat gacacccata agtgtaccaa ataatagtgc
    17701 atattcagat tttaaaaagt aaagaccaat tccagaaagt actccaacta taaaagaatc
    17761 taaaatctta cctgtaaagt atttaccaat atttaaattt aagctttgac atagttctat
    17821 tataaagtct ccatattttt tacctaagga aatataaact actttttttg taaacagtaa
    17881 gaatttttct ttttctaata atatatagaa acaaattata aaacctaaaa gaaattgtac
    17941 tataaatttt ccaactgaaa atgtagtgct aaatatccca ccaagtgaac caataagcaa
    18001 gttactaaat ttaggcatta cactcataat tttgtcacca tactctttta atgtattagg
    18061 gtcaactgat tgtaaactct tgcctaagtc gaataaaaac tgctctgttt tatctatgta
    18121 tgtaggaatt tgagcaacta aatcagctaa actatttact atggatggaa ctgtaaataa
    18181 tataaacgaa attagtataa ctatgagtac accataagta agaagtaacg aatatattct
    18241 cttaaaattt aatttacttt ctaagaactt tactagtggg ttgaatatat atgctaatac
    18301 aaatgctatt ataaatggtg ttagtagtga cattaataaa cttatcactc caaaaaaata
    18361 tttgtaatta tcaataactt taatcaagat atatgaaaca actacagtga gtacaatatt
    18421 tagataaatt tttttatctt gcaaaataac acaacctttc ttatatttat taaatttaga
    18481 tatacttaaa tctaagttaa agttaatatt tatagcttat tatacaataa aaagcagtat
    18541 taatatagta tgattaatat gaaattataa atacgttaaa actttatgtt tatagctaaa
    18601 ataataaaaa ttatttatat tgtgtttata tataatctaa aatgaaaaaa agtggtgcct
    18661 ttgattaaac taagttttta taatttaaat tttgtacaat aagctatctt ttattattct
    18721 ttaaaatata tatttcattt aattatgaca aataaagata aaaattaaat attttagagg
    18781 tgattttatt tagatataga attttagaat aatactatac aaatgtattg tattattatt
    18841 tttatatcaa aaatagtaat aaagtctata tacatttaga aaatactgtt taaaaggagt
    18901 aggatttatg ataaaaaaag agatatctaa ctttagagga agtagtgatt atgtagtatc
    18961 accagaattg atggcatcag ttaatgttgc tattgctctt gaaaagccac ttttgattaa
    19021 gggcgaacct ggaacaggta aaactatgct agcacaagca atttcaaatg aattaaaaaa
    19081 agatttagta atttggaata taaaatcaac tacaaaagca caagaagggc tttatgtata
    19141 tgatactgtt caaagacttt atgatagcca atttggagga gaaggtgtag atgatattag
    19201 caagtacata aaatatggta aactaggaga ggcctttagc tcaaatcaac aagtaattct
    19261 tttaatagat gaaatagata aggcggattt agaatttcca aatgacttgc tttgggaatt
    19321 ggataaaatg gagttttaca taaatgagac aaaagaaact gtaagagcta aacaaagacc
    19381 aatagttatt ataacttcaa atgcggaaaa agaacttcca gatgcttttt taagaagatg
    19441 catatttcat tatatagaat ttcctgatag agacatgatg gaagaaatag ttaaagtaca
    19501 ttttgataaa gtagaagaac acctattgga acaagtaatg actacttttt attggattag
    19561 aagtttaaag gacatacaaa aaaagcctag tacatcagag ttaatagact ggatacaagc
    19621 attaactttg agtggaatgc ctattgaaaa aatagaaaaa gaagttcctt ttgcaggaat
    19681 actacttaag aataatgagg atattgaatc tatgcaaaga cacttatagt taataggagc
    19741 tggataatta tgtttattga atttttttat ttattgaggt caagaggatt aaatgtatct
    19801 ttaaatgaat ggatgacttt aattgaagca ttggataaag gactgtgcta ttcaaacttt
    19861 tcaaattttt actatctttg caggatgatt ttaataaaaa gtgaaagtga ttttgataag
    19921 tttgatgcag tgtttttgga gtattttaaa ggtatagaac accaagaaga aattccagaa
    19981 gagattatga attggcttaa aaaaccagat atagatttag aagagtttga aagattagaa
    20041 caaaatccaa atataaatct tgataaatta agagctaaat tggaggaacg aataaaagaa
    20101 caagattctc ctcataatgg tggtaattat tggataggca caggaggcac ttcagagtta
    20161 ggacattcag gaaaagggca aactggtata cgtataggtg gaaattctac ttatggtaga
    20221 gctgttcttg aagttgcagg agaaagaaaa tacagagatt ttagagatga tgaagtttta
    20281 aatatgcgtc aatttcaagt tgcactaaag agacttcgtc aattttctac tagaatagat
    20341 gctccaaaga cagagcttga tttggataag actattgaag agacttgtaa taatgcagga
    20401 tatttaaagt tattttttga gaagccaaga aaaaatacag tgaagctttt attgcttatg
    20461 gattcaggtg gttcaatgag agggtatagc actttatgta atacattatt tcagtctgta
    20521 agtaaatcaa atcattttaa agatgtaaag atatattatt tccataactg tatttatgat
    20581 agattattta caacacctga atgttggtta agtaaatcta ttaatactga atggatatta
    20641 aaaaatatag ataaaaacta taaagttata attgttggag atgcttctat gtcgccttct
    20701 gagttgcttc atattggtgg taactatcgt ggtccatata attatacacc tggtatagag
    20761 tggcttaaaa ggtttaagag aaagtacagt aaaattgtat ggatgaatcc agaacttaga
    20821 gatggatggg attcaattag ttattggtat caaactcaaa gaatgataca aagtgaattt
    20881 aatatgtttc cattgactgt aaaaggtctt gagaaagcat tgaaaaattt aatggtttca
    20941 agataaagta aatataaatg atggtatgat ttattcaaaa ttgtaccatc attatttatt
    21001 tttttaatat atctattata aattgtataa ctgaaactta aaaaattata tagtctaata
    21061 cattttagac tcacacaaaa catatacatt aataataatt ttagaagtcg aggtgattat
    21121 aataaattat gaattaattg taaaatacaa tggagatata ttgaggttag aagaagaatt
    21181 aggtgtatca gtagagatac ttaattcatc atatgcaata ataacatcaa gtaatgaaga
    21241 agatgtaaat atacttttaa cttatccaga aattgaattt atagaaaagc cttttatatt
    21301 acagactcag gatgtgcaaa gtttttcaag tacaggaata acaggattta aaaatagaac
    21361 tggtttaact ggaaaaggaa ctataattgg tataattgat tcgggaatag attatactct
    21421 acctgtgttt agagatagtg atggaaggtc taagatatta tattattggg accaatctat
    21481 tcaaggaaat ccaccagaag gttttagaga aggaacatta tatactaatg aagatataaa
    21541 taatgcaata gatggaagta tgtatatacc tatttcaaca actagcttac atggaacaca
    21601 tgttgcaggt atttgtgcaa ctattgcaag tgatgccaga ataatagtgg ttagagttgg
    21661 aaatatacag accgatattt tttcgagaag tacagagttt atgagggcaa ttaaatttat
    21721 tttagatagg gcattagaat taagaatgcc tgttacatta aatataagtt atggaagtaa
    21781 tgaaggttca catagaggaa catctttatt tgaacaatat atagatgata tgtgtttatt
    21841 ttggaaaaac aatatagttg tagcagctgg aaataatgca gataaaggag gtcataaaag
    21901 gattaggctt caaaataata ttacagaaga agttgagttt atagttgggg aaggagagcg
    21961 tatattaaac ataaatatat ggccagattt tgttgatgat tttagtgtac atttggtaaa
    22021 cccatcaaat aatcaaacac aagcaatctc tctaacttca ggtgagataa ggaatacttt
    22081 gggtgaaact agaataactg gttattttta ccctatagca ccgtattctc tcacaagaag
    22141 agttactcta caattaagtt caaatacaca gataactcct gggttatgga aaattgtatt
    22201 tgaaccaata gatatagtaa ctggtaatgt aaatatatat ttgccaactt ctgaaggtct
    22261 aaatagaaat actagatttc tgattcctac tcaagagctt actgtaacag ttcctggaac
    22321 agcaagtaga gttataacag taggtagttt taattcaaga acagatatag tatctatatt
    22381 ttctggtgaa ggagatacac aattaggtgt ttttaaacct gatttattag ctccaggtga
    22441 agatatagta tcttttttac caggaggtac aagtggagca ttaactggaa ctagcatggc
    22501 tacacctcat gttacagggg tttgttcatt gtttatggaa tggggaattg taaatggaaa
    22561 tgatttattt ttgtattcac agaaattaag ggcattactt ctaaagggag caaggagatt
    22621 aagtaatcaa tcttatccaa ataattcatc aggatttggt tttttaaatt tatcagatat
    22681 agatttgtac actctatcta atataaatca agatttagaa acagaggata ttggatatag
    22741 aagtattaat aagtcattta aagatgagga aaatagttat aagtttatag atggttataa
    22801 tatgcaaata cataatgact tagagaatga aatttatata agtaaaaatg caagtagaca
    22861 atcaggaata ctatcaggaa tagatatagt ccatactcct gaatttgaag aagaactagc
    22921 tgggttaggt atgagtcaaa ggttttttaa gataagtgat tcattaggtg tactatctat
    22981 aaataataca gactataata gcatacaacg agttttgcaa cttccttcaa tcataagaac
    23041 tgtatcgact acaaagatga cattacttgg agaaattaat cgaggtactt ttggaggtgt
    23101 agttgcaaca gaagaaatgg gcgtaaattt ctttaaaaat aatcctaata ttaatataac
    23161 aggaagaggg actctaatat caattgcaga tacaggaata gactatctac acccagattt
    23221 tatttatcca gatggcactt caaaaatagt atatttatgg gaccaaacaa aagaaggaac
    23281 tcctcctgat ggtttttata ttgggacaga atatacacga gaagatataa atcgagctat
    23341 cgcagaaaat gaccctagtc tatctcagga tgaagttggt caaggaacta tgttgagtgg
    23401 gatatgtgca gggcttggaa atgtaaatag tgaatatgca ggtatagcag aagattctga
    23461 gctaataata ataaaactcg gcaagataga tgatttttat aatagtgcaa tgttgtttgc
    23521 tgcatctcag tatgcatata aaaaagcttt tgaacttgga agaccattag ttataaatat
    23581 gtctttaggt accagtagcc tagcaggttt aaccaatagg agtaatagtg aaaaagcgtt
    23641 ctttactaga gggttatgta taacggcagg agcaggaaat gagggcaata cacagacaca
    23701 tacatctgga ataataccat atgttggagg ttctgttgaa gttgaattag agttaaatga
    23761 agacgaggaa gaattatcat tagaactttg gttaaataga ccagataaag ctgatgtaat
    23821 aatagtatct cccactggtg aagaaagtaa aagtgttgga atttcaaatt ataataaagt
    23881 aacaggttta tttgatttag aggggactga atattctata acatatatat acccaacaac
    23941 tttttctgga cagcaattta ctaatgttac tttaaagaat gcaaaaagag gtgtatggaa
    24001 gattcgatta gtaggagttt atattataac aggaagatat aacttatacc ttccaaatag
    24061 agaactttta aaaagtggaa ctagatttag agaggtagac cctttttaca ctataaatta
    24121 tcctgcgatt caagatgatt taataaccat aggagcctac aataccatta atggtagttt
    24181 atggcaaagt tcatcaagag ggccaactat tgaagacagg ttaaaaccag atatagtagc
    24241 accaggtgtc aatataatag ctgcttatcc tgggaacacg tatgcaacta taactggtac
    24301 agcagcagca agtgcacatg cagctggtgc tgctgcaatg tattttcaat atacttttgt
    24361 tgacggtaga tatccaaacc aagcatatgt gcaaaaaata aaaactttta tgcaagctgg
    24421 tgctagaaaa gattcaaaca cagtatatcc aaatacaaat tctggatatg ggctcttgga
    24481 tgttagagga atgtttgatg ttttaagata ggagggattt atggaaaaat cttattgtat
    24541 aatttatcaa ggtgatatag aatctgccct acaagaaaat ggaataaata ggtatatggt
    24601 tttaaatagt cagcttgcag taatatatgt acctttagat tttgatgaaa ctattttaaa
    24661 taatataata caagttgctt ggtgggaaga atctgaacca atgagcagtc taattgaaat
    24721 aactaataat gtaaataatg gagaaaccat tacaacagca gctgaaactg attatattta
    24781 tgaaaatcca tataatgata taacagggag aggaatttta ttagcagtta tagattctgg
    24841 gatagattat ttgcatcctg attttataaa tgatgatgga actagtaaag ttttatattt
    24901 atgggaccaa gaagcaaata caaatccacc tccagaaggt tttatttttg gaagtgaatt
    24961 tacaagaagt gagttaaata tagccataaa tagaaatgat gggagtttga gtcaagataa
    25021 tataggtact ggaactttag tttctggtat attagttgga aatggaagga taaattctca
    25081 gtacagaggt attactacag aatcagactt aatagtagtt aaattaaaat catatacaga
    25141 tacttattat gctggaagga taaattacag tgtttcagat tttttagcag ctataacgta
    25201 tgttactaac atagcaagaa cagaaaataa accactgata ataaatttga ctattggagt
    25261 taagtcaagt gctgtagcaa ctacttcaat actagatact tttaatatat tgagtagtgc
    25321 tggtgtggta gtagtgagtg gtgcaggaaa tcaagggaat acagatattc attattctgg
    25381 cagatttagc agtgtgggag aagttcaaga tgtaataata caagatggag atgactatgc
    25441 tcttgatata acactaaata cgaatggtcc agataaagtg ggagcacaga taatatctcc
    25501 ttcaggtgaa gttagtcatg atataaggta ttctccagac ttttatatat atagaggaaa
    25561 atttaactta gaaaatacta cttatgcaat gagatttatt tatccatata ttacctctgg
    25621 aaaagaaaat ttggagataa gattaagaga tataaaacct ggagtatgga ttttaagatt
    25681 gacttcagaa cttataataa atggagaata tgacatatac ttgccaaata aaaatttgat
    25741 agctccagac acaaggtttt tagagcctga ttcagtagct actataacta tgtatgctgc
    25801 tagtgatgat gtaattacag ttggtacatt taacaataag actgatagta tgtggattgg
    25861 ttcttcgaaa ggaccaatta gaggaagagg aattaagcca gatatagtag cttcaggtgt
    25921 agatataata tccacatata aaaatggaac atataataca ggaacaggaa caggagtgag
    25981 cagttctata gtcacaggtg ttttagcctt attgatggaa tacttagaaa aacaggataa
    26041 tgtaccgaga ttatcattgt ttacacaagt tttaaaaaca tatttaatat tgggtgctac
    26101 aaaacttgag atatatacat atccaaatgt atcgcaggga tatgggattt taaatttaaa
    26161 aaatacgatt caacagatag caaatactct atagataaga acctatgtaa aattataatt
    26221 gattattagt ttaattgtat caaatacttt agatagagta gaaaaatagc ataaaaaata
    26281 aatatgaaaa ttaaaaaaca gttttatatt ttgaatacac aaagtaaata ttttgtatat
    26341 aaataggtat aaattaagta ttgaaaagat attatgttaa tttaaaaata attataattt
    26401 agacttatga attttatttg taaaattgct aaaactatta caaaataaat aatagaggtg
    26461 atagttttgg aaagtaaaaa ggcaagagca ttaaaaggta aagataataa aagacttaaa
    26521 agttcacttt tagttggaaa tgagtcgaca gcagcatggg ctgatgttga aaaattaaaa
    26581 cctcatagta aagtttcaat accttcaatt aagggtgtcg aagaagcaaa agactgggtt
    26641 gacaatggaa gtaaattata aaattttgga aattgaagta ataaagaagt aatgaagata
    26701 agtatttatt atcattatgt aaggtagaat tattatattt taaataacaa tcagtatcaa
    26761 ttatataaat ttattgacta aaaatttata aattggtata attttgttaa ttagcagaaa
    26821 taataaaaga taaatactgt gaagagaaga gtagatataa aatgtagttc tagcgagttg
    26881 aggatggtga aagctcaata cgaggtttat attgaagaac atcttggagt ttctaatcga
    26941 aagcttattt agtaagtaga cttagacgga aggcaccgtt ataggcttta agcattgctt
    27001 aactaagagg tcattatgac aactagggtg gtaccgcgag agtaatagtc tttcgtccct
    27061 ttatataggg atgaagggct ttttttattg aaattatatt taaaagaaat taataacaat
    27121 tatactagga ggatttaaaa tgcaaaagga atttataaca gtaaaagaat tgtacagaga
    27181 aaaagaacag tacataggga agactgtaaa agtagctgga tggataagaa catctagagt
    27241 atctaaaaat tttggattta tagagctaaa tgatggaagc ttctttaaaa atatgcagat
    27301 agtatttgat gagaaagtag aaaattttaa agaggtagga aaattagcaa taagctcatc
    27361 tatacttgta gagggagagt tagtatctac agaaggggct aaacaaccag tcgaaataca
    27421 tgcaaaaagc atagttgtag aaggggaatc agatagttcg tatccactac aaaagaagag
    27481 acatacgctt gaatatttaa gaacgatagc acatttaaga ccaagaagta atactttttc
    27541 agctgtattt agagtaagat caatagctgc ctatgcaata cacaaattct tccaagaaag
    27601 aaactttgta tatgcacatt ctccaatcat aacaggtagt gactgtgaag gtgcaggaga
    27661 gatgtttaga ataacaacta tggatttaaa tgatattcca aaaactgaag atggcaaaat
    27721 agactatact caagatttct ttggaaaaga ggctaattta acagttagtg gtcaattaaa
    27781 tgccgagata atggcacttt cttttagaaa cgtttatact tttggaccta catttagagc
    27841 tgaaaactct tatacaggaa gacatgcttc agaattttgg atgatagagc cagaaatagt
    27901 ttttgcagac cttgaagata acatggaact tgcagaagat atgataaaat atgttataag
    27961 ctatgtatta gaaaatgctc ctgaagaaat ggaatttttt aatagtttta tagataaagg
    28021 attgttagaa agattaaata agatagtaaa ctctgagttt attagaataa cgtatactaa
    28081 agcagtggaa ttattaattg aatctgggca tgaatttgag tatcctgttg agtggggatg
    28141 tgaccttcaa acagagcatg aaagatatat aacggagcaa atatataatt gtccagtgtt
    28201 tgttacagat tatccaaaag atataaaagc tttctatatg agaatgaatg aagatggtaa
    28261 aactgttaga gcaatggatt tactagttcc tggagttgga gaaatcgtag gaggttctca
    28321 aagagaagaa agagaagatg tattgttaga tagaattaat gaaatgggat taagagaaga
    28381 agattattgg tggtatttag aacttagaaa gtttggtact gctactcact ctggatttgg
    28441 tcttggattt gaaagaataa ttatgtatat gacaggtatg tctaacataa gagacgttat
    28501 acctttccca agaactccta aaaatgctga attttaataa ttatatataa taaaacttat
    28561 ataactttaa gtataaacac taaaatgact tgcatattta tctattttag agatatgcaa
    28621 gttattttta ttgtactata aatatataat ttgattactt ttattttgcg atataatact
    28681 tataggttta tgtaatagta tgtaaccttt taataaaatg caacacaatt acgtccttgt
    28741 tcttttgcag tatatagggc cttatcacaa ttacttataa actcatttaa tgttattgtc
    28801 tttccaattt tctttgtata aactccaata ctaacagtta cacattttaa aggaacatca
    28861 tcacgctcaa aattgcagga ctctataatt tttcgtaaac attctgattt aagtttagca
    28921 tctgcctcat tacagttaaa aatacatata aaaaattcct caccaccata tcgtatagca
    28981 tgttcatttt cagaacttgt aaaatctaaa attactttgg caatattttg tagacaatag
    29041 tctccctttt gatgtccata attatcatta aattgtttaa aataatctat atctatcatc
    29101 attccagtta taggttcttg atttgcatgg ctgattaatt ttttttgtag aatatcttca
    29161 aggtacctac ggttgttcat tttagtaagg tcatctgtca taactttgtc gttaagtaaa
    29221 ttatttatat gagatatttc ttcatattgt tgactaatta aaagtttatc atagtaagta
    29281 aatacacgat ttctatatag cattgtagaa acaaaaatgg caagggatgt tataaaaaat
    29341 gtgttgacaa tattactaaa ctcattgcct ggtatagttt gaatcccagg taagaataaa
    29401 ttaagaaaca aaaagcatcc tccaaaaact attactgatt ctccaaattt taatactgag
    29461 aaagctgcag ctgctaacat aatataacta aatacactta ggtcatttcc acctaactgg
    29521 tcaagtagag taattacaca accccatagg cagaaaaaag tcacataaat tatccataaa
    29581 tttatataaa acgtacagca atcctttttt ttattccaaa ggtaagaaaa tacaaacata
    29641 aagacagaag atacacaaaa tagtgttaca tacatataaa aataccattg gcgtcttggt
    29701 gtgacaaaag ggcctccttc tctagctgag attgatatca tcataattat ttgagatatt
    29761 actattatta tgcaaatgat tttacccgta tgataaagat aattgcagag ttctttctca
    29821 acattgtctt tgtgtttttt gtctagagga aatccaaaaa atttttttat tttttctaag
    29881 ttcatataag cctccattaa aaataaagca taaaaataag tattcctttc tatcattaga
    29941 tatttggaat acttcgttta tgatttaatt atatcaaaat atattgtgtg taacaatcta
    30001 aaattgtgat agataaaatt tattagataa tgtcgagtaa ctttattgat taatacttta
    30061 ttataattaa gatttacaga tagtttacta ctgaaaataa agaatagaat aaatttaaat
    30121 taagcataat aaaatataaa taataaagtt cgcattaaca aactatttaa atatcaagac
    30181 ctgttaaaaa acaacagcaa taaacaaata aaatagataa atatatccaa ttaaggtata
    30241 attaagtttt atatgatata gttatatttg ataatttaca atagtaaaac ttggagggaa
    30301 aaaatgggtg aaaagaaaat aaataatatg aattattcac ataataatta ttccaaaaag
    30361 acaggtgaac caactagaaa aataaaaaat agccatatca ctcttaaaag taaagaagaa
    30421 aaaatttgtt ctagttgcaa taaagaaaat aatactaagg ataattactg taaattttgt
    30481 ggaaatgaac tttatgaaat agcatcatta agaccacttg aaacaaaact agacttgaaa
    30541 tctaaaataa aagagctttc atatcatgca aataaaagag gtgtattttt aacaacattt
    30601 acaaccatat ttatattgtt tattattgca ttgatattta aagctattat aactattcaa
    30661 tttaatgata ttagttattt aataaatcca gcacatataa tcctagctct caacttgggt
    30721 caaattagtg tatctatgtc taccatgatg ggttctgggt ttataaatgc caatataggt
    30781 ttgttgatat tacttataat ccctattttg gtattattaa tatcaaacct aatttttatg
    30841 agaaaaagat gtagagattc aaaaactgta ttagcaaatt ctctaggagt tggaattttt
    30901 tatggattag ttttagctat tttatctatt tttactaatg taaaaactag ttcacatagt
    30961 atgttagaat atggatatgc attagaatat agttatgaat tttttagtgt tcttttaaat
    31021 ggatttgtat tagggtttat atgtacatac ataactactt ataaaaaaag ttatgaaaag
    31081 gaaaatatgt atttatctct tttttcaaat tctataagaa cattcatatt aggttatgtt
    31141 ttagtattag taatactatt ggtactaact atatctgata gtagttactt aaatgaacta
    31201 gatatgagta gttattcaaa tggattaaat ttatttacta tactcccaca aatagctagt
    31261 tatatgtggg cttttgcaaa tggaatttca gtaaccataa taaactcaac agtatcaatg
    31321 tttactttaa gttcttcatc tttatttgga gatactaaat taatgtttta tgcaatggga
    31381 gcattgtcta tgttaatatt attattaaat ggatacaagc taagatttaa gtataataca
    31441 gatagtataa gacctataat agtatttagt atatattatg catttttgat gggaatattg
    31501 gctttattta gtacatttat actagatagt aatattaatt tctttaatac aactaattat
    31561 ggaacaactt taataatgca atttaaagtc ttacaagcta ttgtaatttc atttgtatat
    31621 agttttgtga tatctttaat aggatataag ctaaattcag ctgattaaat atgattggag
    31681 ggaatttctg tggaaggaaa tactaataat aaagtagatg ataaattttc taaggttaag
    31741 aaaaagtttg gtagtggaaa atttaaagtt gaattatata aagaaaaatc aaaattaaat
    31801 agagagattg atgatattca agaaaagaaa gcaaagatat tcttggaaat gggaatactg
    31861 acatatcaaa aaattagaga agattctatt aatgataata gttttgataa attctgtgat
    31921 gagttactag aacttgataa gttaatttat gaaaaaaata tggaaattaa tgaaatggaa
    31981 atggcagaaa gtaatgtaac ttgtgagtgt ggttatgttg gaaatgtaaa tgataaatat
    32041 tgtgctgaat gtggtaaaaa atttgaattg gaaaatgaat gtgatgattt tataatttgt
    32101 ggttattgtg aaagtgagat agatacagag gctgaatttt gtccatgctg tggaagaaaa
    32161 attataatgg atttagaata atattgggaa acctatgtat agtatacatg ggttttttta
    32221 ttgaaattat ttaaatggac ttataacagt agttatataa aatgaaaata aacaccaaaa
    32281 aaatgaaata aaatttcttt taaatgtaaa aaacaagcta atatataaaa taaatcagta
    32341 aaaatataga tgcgagaaaa aaatatgaaa aaatattgca aagaaaaagt tttcatgtta
    32401 ttattaatac ataaatcaag aaaataaatt tcagaaacga ggtaatttaa aaaatgctag
    32461 ataaggtaaa gggaagatta atagtatcat gccaagcttt agaagatgaa cctcttcata
    32521 gtccttttat aatggggaga atggctaagg ctgctatgga aggtggagct gttggaatta
    32581 gagctcaagg agttgaagat attattgaaa taaaaaaagt tactggactt cctgttatag
    32641 gtattataaa gagaaactat gaagattcag atatatatat aacgccaact aaaaaagaag
    32701 ttgatgaact tttaacaaca gggtgtgaaa tgatagcatt agatgctacc aatagagtta
    32761 gaccaaataa tgaagactta aaagaactta taaagtatat aaaagaaaac ggtgttctag
    32821 taatggcaga tatttcaaat tatgatgagg ctatcaaagc acaagagtac ggtgtagatt
    32881 gcgtttcaac tacactatct ggatatactc catatactaa aacattagaa ggtccagatt
    32941 ttgtattaat ggaaagatta gttaaagatt tagaaatacc tgtaatagct gaaggaaagg
    33001 taaatactcc tcaagattta aaaaaggtct ttgagttggg tgttcattca tcagtagtag
    33061 gttcagcaat aacaagacca caattaataa cagaaaaatt tgttaaagca attgaaatta
    33121 attaaaaatt aatttataaa ttaaaaaatt attatattta actatatttg aaaattaaaa
    33181 ttggaggtaa agatatgaga acaacagata tgaagggaat ttattcagca ttattagttt
    33241 catttgataa ggaaggaaat ataaatgaaa aagggttaag acaaataatt agacacaata
    33301 tagatgtttg taaagtagat ggtctttatg taggaggaag tacaggggaa aacttcatgc
    33361 tttcaactga tgaaaagaaa agaatatttg aaatagctaa agatgaagtg aaagaagaaa
    33421 taaaattaat agctcaagtt ggttcagtta atttaaaaga agctgtagaa cttgctaaat
    33481 ttacaactga tttaggatat gatgcaataa gtgctgttac acctttttac tataaatttg
    33541 attttgaaga aataaaacac tattataata caataataaa ttctgtagat aatagattaa
    33601 taatatactc tataccattt ttaactggtg ttgatatgag tttagaccag tttggagaat
    33661 tatttgaaaa tgaaaaaata ataggtgtta agtttacagc agcagatttc tacttattag
    33721 agagaatgag aaaaacattc ccaaataaat taatatttgc aggatttgat gaaatgatgt
    33781 taccagctac agttttaggt gtagatgggg caattggttc tacattcaat gtaaacggtg
    33841 tcagagctag acaaatattc gaattaacta agaatgaaaa aatatcagaa gcacttgaag
    33901 tacaacatgt gactaatgat ttaataacag atatattagg aaatggctta tatcaaacaa
    33961 ttaaattact acttgaagaa caaggtgttg aggctggata ctgtagacaa cctatgaaag
    34021 aagcaactga tgaaatgaaa tcaagagcaa aagaaatata cagaaagtat ttttaataaa
    34081 atacttttag tatgggagga ttagtcaaat ggtaggattt acttggatag attttgcaat
    34141 actagtggtt tacttattgg cagttttatt tgcaggattg ttattttcaa aaaaggaaat
    34201 gaagggaaaa gagttcttca aaggtgatgg aactattccg tggtgggtta catcagtatc
    34261 aatatttgcc acattattaa gtccaatatc atttttatca ttagcaggaa attcttatgg
    34321 tggtacttgg attttgtggt ttgcacaatt aggtatgttt atagcaatac ctttgacaat
    34381 aaaatttttc ttacctctat atagtaggtt agaaatagat acagcatatg aatacttaga
    34441 aatgagatac gaaagcaaag gtcttagagt acttggagct ttgatgttta taatatatca
    34501 aataggacgt atgtctatca taatgtatct tccatcaata gttctggctg gtcttacagg
    34561 aatacctgta aatgtactga taatagttat gggtgtaata gcaataattt actcatatac
    34621 aggtggatta aaggctgtct tgtggaccga ttttatacaa ggaatggtat taatagtagg
    34681 tgttacaggg acattgttct atttaatagc aagtataaat ggtggttttg gaacagtaat
    34741 ggatactctt acaactggac acaagttctt agcaagtaat gaagttatgt ttgataaaaa
    34801 tatactatct acaagtgcat ttataatatt tgttggagct ggtcttaata ctttttcatc
    34861 atatgtatcg agtcaagaca tagttcaaag atttactaca acaactgata taaagcaact
    34921 taataaaatg acatatggaa atggtgtttt atcaatggga cttgcaacag tattttatct
    34981 aattggaact tgtttattta tatactatac tcaaaaccca gatttagctc aaacagttca
    35041 acaagaccaa gtatttgcat catatatagc ttatgaatta ccagtgggta taacaggaat
    35101 actacttgca gcgatatatg cagcttctca atcaacttta tcgacagggc ttaattcagt
    35161 tgctacaagt tggactttag atatacaaac tatcataaca aaagatataa gtatggaaaa
    35221 gcaaactaag atagcacaat atatatcatt aggtgtaggt atactttcta tagctgttgc
    35281 aatagtatta gcaaatggag aaataaagtc agcatatgaa tggtttaata gttttatggg
    35341 gctagtacta ggtgttttag caggaatatt tgtacttggt gcattttgta aaaaagcgac
    35401 taaaatggga gcatatgttg gattcatagt atcagcaatt ttagttgttt atttaaaata
    35461 ccgtatgcca gaagtaactt cttgggcata ttctctaata acaatcacga cttctgtagt
    35521 ggtaggtaca atagttagtg caatagaagc taaagttaaa gcaaaagtat ctttaccaaa
    35581 agctgagact actgtttatt atgaaaaata atatttaaat gataaattgt cttatagagt
    35641 gattagataa ataatttagt tactctataa gattgtataa tatactttgt atataaaagt
    35701 ataaaaatag actttataat tatataggga gatagtgctt atgatatttg gaaatataaa
    35761 tcatagtaag acatattcaa cattgcatga agatttactt agatgttttg aatatgctaa
    35821 agataattca ttaatagatt atgaaaaagg tacttataca atagatggtg atgatatttt
    35881 tgtgaatatt gtagagtata aaacttgtga aaaagaagat agattctggg aagctcataa
    35941 gaagtatata gatgttcatt tgatgcttga tggatgtgaa cgaatagata taaattttat
    36001 agaaaattta gaacaaaaaa tatatgaaga aaagggcgat ttcttgcctc ttgatggtaa
    36061 aaataatgga tacatggaac ttagaaaagg tgatttttta gtttgttatc cggaagatgc
    36121 tcatatgaca ggaataaaag ttttagaaaa agaaaatatc aaaaaagcta tttttaaggt
    36181 tttggttaga taatgataat ttatataacc actagggctg aaaatagtga tttaactttc
    36241 agcgattagt gagacttcgt aaattttagt tagattacta ttttcagcct tagtttttta
    36301 tgagaaaatt gaaaataatt aaaagcttaa aattttgtaa aggagttaac ttatggaaaa
    36361 tatagatgta ttcttattaa taggacaaag caatgctaga ggattgggaa atccaaaaga
    36421 gagcatcatt ccaaatgaaa attgttttga atatttgagt actgatgaaa ttataaatat
    36481 gagatgtgag ctagagactt cagaaggtga tggtactata gcacctgcat tttcaaatga
    36541 atggaataag cttactggaa ataaagtttg ttttattcac aatgcaaaag atggttcaag
    36601 aataaaaaac tggaatcatg ataataactg gtttctaaat gacactatag aaaaatttaa
    36661 tacaggctgt actaccttaa gtaaacatta taatatagaa aataaatacg ttatttggat
    36721 tcaaggtgaa agtgatgcaa aatatggtag tgatgtattg tactataaag aaagtctaaa
    36781 aaaaattgcg tataggctta aagaagaatg tatgattgat aaaatgtttg taagtttaac
    36841 tggttattgg cttggagaag atgaatattt tattagaaca agacgaattg cagcagcaca
    36901 ggagtcggct tgtagtgaat gtgatatatt atgtgtagga agcaaaattg ctatgcagtt
    36961 tcatgacaga ggattaacta ttgatgatgt tcattacact caagaaggtc ttaatatgtt
    37021 aggagaggac ttatgtaaaa atatttataa gtatcatata accaaagaaa aaagtgtatt
    37081 aagtgatact atagacttat cagaagcaag gaaatatatc tgtgaattgg aaaagataag
    37141 taaaagattt gtgtaatata aaattttaaa tagagttgtt aatttataaa aataatttgt
    37201 atggagatat gttatgaaaa attacgtttg tatagatgtt gggggtactt caataaaata
    37261 tggttttatt agagaagatg gatttataat tgataaatca agtcttgata ctgaagcaaa
    37321 ggaaaaaggt ggagaaggaa tattagccaa aataaaagat atagtaaaaa aatatataga
    37381 ggaaaatgaa ataagtggta tatgtatatc aactgcaggt atggttgacc cagttgaagg
    37441 taaaatacta tttgcattag aagaattaat tccaaactat aagggcatgc aattaaaaaa
    37501 agaagtagaa aaagagttta atataaaatg tgaagttgaa aatgatgtta attgtgctgg
    37561 acttggtgaa atgtggcttg gagcaggtaa agatgcaaca tcttctatat gtttaacaat
    37621 aggtactgga attggtggat gtattataat aaataataaa ctgataaatg ggtttagtaa
    37681 tagtgctggt gaagtaggat atatgaatgt aaatggaagt tcttttcaag aattggcatc
    37741 tactagcagt ctaattaaaa aagtagcaaa aataaaaaat ttgaatgaaa atgacttaaa
    37801 tggaaaaata atttttgatt tagcaaagaa taatgatgaa gattgtttaa aagaactcga
    37861 taatatgata aaatcattag cagttggaat cgcaaatata tgttatgtaa taaatccaga
    37921 agtggtaatt ttaggtggtg ggattatggc acaagaaaag ttcctaaaac caaaaataga
    37981 caaagcatta aaggaggttc ttatagagag agtttacaaa aacactaata tagaatttgc
    38041 aaagagacaa aatgatgcag gaatgcttgg agcattatat aattttttaa acaaaatata
    38101 aagaatagaa gggtttttaa tgagtatttt agaacaattg gaatcaccaa cttttaaagt
    38161 cacaaaatca gataaattat taatagctta tataaaagaa aatatagatg atgtatttta
    38221 taaaccaata tcacaaatag ctaaagagag caatattggt gaagcaacta taactaggtt
    38281 tgtaaaaaaa atgaatttta atggattaca ggattttaaa gttactttag cacaagaaat
    38341 atcaactatc aataaaaaaa atattataaa taaaaatata caaaatgatg agccagcttt
    38401 ggatacagca aaaaaacttt taagttcaaa tgtaaccact ttagagaaca cagtagagat
    38461 aatcaatagt aaggatgtac atgactgcgc aaggcttata ataaatgcaa agaaagttta
    38521 cttcataggt attggatatt ctggtataat agcacaggat tcaaactata aatttatgag
    38581 aataggtctt aattgtgtaa gttttgacag tagtcataca atgataatga tgtcttccat
    38641 aatggaagaa ggagatttaa taattgcaat ttcacattct ggtgaaacag aagagattat
    38701 aaaaactgta aagcttgcaa gagccaataa tgctaaaatt atatcaatta ctgaaaataa
    38761 aaattctgaa ttaaaggata tttcagatgt acacttatct tatgtatcgg gagaaacagt
    38821 actggaaact ggttcaatat cttctaaatt agcacaattt ttcattattg atttagtata
    38881 tacacaggta gtaaaagaac tttctaatga agctattgaa aggaaaatta aaactacaaa
    38941 tgctataaaa ttgtttaaaa atgaataaaa taagaaattt gtaatgtttt atagagctct
    39001 cttaaaaatt taggaatgga gagatattac atgtctaaat taaaagatta taatattgat
    39061 aaagtaataa tttttaataa tttaagtact aaaacgaaga atcaacttaa agaaaaagtt
    39121 aaactaaaaa gattacaaaa aaaagaaatt ttattttatg aaaaagatag cttagacagt
    39181 gtttatatac ttttagaagg aaaggtatct atttttaaga taagtgaaaa tggagagaga
    39241 aaagtaattt tcatattaaa tagtggggaa gtcataaatg atattacact tgacgcttct
    39301 aaaaactcta ctgttggctg tgaagcattt gaaaattcaa ttgtagctta ttatagtatt
    39361 gaagaatttt tagaaattat gcaaaatgat tttcaactta caaaggatat tatttcttat
    39421 atggaaagaa gaataagacg tttatataga cagttgaaaa attctatatc cataaaagta
    39481 gataaaaaac ttgcagcaaa attatatagg ttaagtagag aatttggagt ttgctgtgga
    39541 gaatggactt tactaaatgt aaatattaca gttacatatt tagctgatat gcttggctgt
    39601 aaaagggaga ctgtttccag aatgataaag gtattgcaaa aagaagaact tattaaaatt
    39661 gacaataaag gtttttatgt taaagaaact gaattatcaa ggtattttaa aaataattaa
    39721 ttatgattaa gtaagagtat tattagaatt ttaattaaat aaaaatatta ttaagagaat
    39781 ctatttatag attctttttt attgtctaat ttattaattt ttattttacc ctattgaatt
    39841 gtataaaaaa acaaataaga ttctttttta ttcaaaaaat tgagtagata gtagttttat
    39901 tgtacttaat gattgtattt aagtgattag atttgaaatc gaataatgta gataataaaa
    39961 aaatattaac agaacttaat aaactccatt aatatttttt ttattatttt tgaaactgtg
    40021 ataattatca cggaagcata gaaaataaag tgttaagatt taaacaagat agcaagtaag
    40081 taaaactaaa atataagaaa ggtgataaaa atgaaactaa aattagattc atctaagttc
    40141 aatgaaggtc tgaattatct aaaaaaagac tacaagatat ttgcaccagt tttaatccca
    40201 tttaaaggta ctttttcaga tactgatgtt ataagataca aggaggtaaa cgcttttgaa
    40261 gaaatggaat ttgctaagaa agcaaacttt tcaccaaaag aagttgtact tcccataaat
    40321 caagtattgt tttattttac tgaaaaagag tttaaggaaa gcgatttaga caacaagaaa
    40381 attttaattt tcttaagagc ttgtgacata aatggtataa aaagacttga tgaaatatat
    40441 ctaaataatg gtgaagaaaa agattatttt tataaaaata tcagagataa agtaaagttt
    40501 gcacttgtag ggtgtaagga aagttttaga aactgttttt gtgtgagcat ggattctaac
    40561 aaaactgata attattcaat tggattaaat atagaaggag atacactgta cttagatata
    40621 aaggatagtg aatttgaagt atttaatgga gaagcaactg aatttaatgt tgattatgta
    40681 actgataatt taatatctgt agatgtgcca gagaatattg attcaaatga aatgatagga
    40741 aattcaatat gggatgaata tgatacaaga tgtataggat gtggtagatg taattttgta
    40801 tgtccaacat gttcatgttt tacaatgcag gatattttct ataaggaaaa cgaaaatgta
    40861 ggtgagagaa gaagggtttg ggcttcttgt caagtagatg gatatacaga tatagcaggt
    40921 ggaaattctt ttagaaaaaa acaaggcgaa agaatgagat ttaaaactat gcataaaata
    40981 catgatttta aaaaaagatt cggatatcat atgtgtgttg gctgtggaag atgtgatgat
    41041 gcctgtccgc aatacatatc attttcaaag tgtatagaaa aaataaatga tttagtaatt
    41101 agtaaggagg aagtataaat gaacccatat ataccagtaa gtgcaaaaat actagatata
    41161 gttaaacata ctgataaaga atggactttt agagtaaact gcaatacaaa aggtgtattg
    41221 cctggaaagt tttatgagat atctatacct aaatacggtg aaagtccaat atcagtatca
    41281 ggatatggag aggattatat tgactttaca ataagaaatg taggaaaagt aactagcgag
    41341 ttgtttaatt ataaagaagg agattctttt tttataagag gtccttatgg aaatggattt
    41401 gatgtatccc tttatgaagg aagagaaatt gtagtagtgg caggaggaag tgcattagcc
    41461 cctgtaagag gaatagttga atatttttat aataataaag aaaaatgcga aaagtttaaa
    41521 ttaatagtag gatttaaatc accaaaagat attttatttg cagatgattt aaagagatgg
    41581 agtaaaaaac ttgatatttt agttactgta gatggagcag aggaaggata tagtggtaat
    41641 gtaggattag taacaaaata cataccagaa ttggatatga aagatataaa caatacttct
    41701 atagttgtag ttggacctcc aatgatgatg aaatttacag tagaagaatt tttaaaaaga
    41761 gatttagatg aaaagaacat ttgggtttct tatgaaagaa aaatgtgttg tggaataggt
    41821 aaatgtggac attgtaaaat ggatgatact tacatatgtt tagatggacc agtatttgat
    41881 tattcatatg ctaaaaatct tattgattag ggggtgaagt ttgtgataag agatttaaat
    41941 accaaaaaag taatgaaaaa tgcttataga attacaaaaa caaaatatga gacttcttta
    42001 agagttagag tacctggagg tcttattgac cctgagagtt tagctgtagt ttctaaaatt
    42061 gcaagtgagt acggcaatgg acaggtgcac ataactacaa gacaggggtt tgaaatatta
    42121 ggaataaata tggaagatat ggaagaaata aataaaatta tacaacctgt tattgaaaaa
    42181 atgaatataa atcaaagtga gaaaaacgca ggttatccag cagcaggtac aagaaatata
    42241 gcagcttgta taggaaataa agtctgtcca aaggctcaat ataatacaac tgaatttgct
    42301 aaaagaatag aaaaagctat atttccaaat gatttacatt ttaaagtggc tttaactggt
    42361 tgtccaaatg attgtataaa agctagaatg aatgactttg gaattattgg tatggcttta
    42421 ccaatatatg aaaaggatag atgtgtaaat tgtggagcat gtgtaaaaaa atgttctaag
    42481 atatctgttg gagcattaaa aacagaaaat aataaggtgg taagagataa agataagtgt
    42541 ataggctgtg gagagtgtgt gctaaattgc ccaacaaatg catggactag agatgagaaa
    42601 aaatactata gattagctat aatgggtaga acaggaaaga aaaaccctag actagcagaa
    42661 gattttcttt tatgggtaga tgaggacagc ataataaaga taatacttaa tacttataga
    42721 tatgtagaaa agtatataga taaagatgca ccaggaggaa aagaacatat aggatatata
    42781 attgatagaa caggatttat ggaatttaaa aaatgggcac ttgaaggtgt agagcttcca
    42841 gaaataacta aaatgtacga aaacatatac tggagtggaa ttaaatatct ataaattgag
    42901 taaaacatat atttgaataa attaaaattt aatagaagga agagggaatt atgcataaag
    42961 aaactttgga taaattaact aatgcagcta taaataagat aaatttatta aacacaagta
    43021 aagtaaaata tttggtatct tctgcgtttg caggacttta tgtaggtata ggtatacttt
    43081 tgatatttac tattggagga cttttgactg atgcaggttc acctatgact aagatagtaa
    43141 tggggttatc atttgcaata gcactaagtt tggttataat gacgggaaca gagttattta
    43201 ctggaaacaa tatggttatg tctgctggta tgttaaataa aggtgtaagt ataaaagata
    43261 cttctaaaat atgggcatac agttgggtag gtaatttaat cggagctttg gttttaggca
    43321 ttatatttgt aggaactggt ctaatagaca aaggacctgt agctgaattt tttgcaaata
    43381 cagcagctag taaagcatcc atgccattta cagctctttt ctttagaggg attttatgta
    43441 atattctagt atgtgtatca gtgttgtgtt cgtttagaac taatagtgat actgcaaaaa
    43501 taattatgat attcttatgt ttatttgctt ttataacatc aggctttgag catagtgtag
    43561 caaatatgac aatttatagt gtttcattat tttcaccaac aataaataca gttactattg
    43621 gaggagctat ttataattta gtagctgtaa cacttggaaa tattgttgga ggagctttat
    43681 ttatgggtct tggaacttat atattaggta aagaaaagct taattaaatt tattgtataa
    43741 attataactc tcttgataaa tgcattttta gtattgttga gagagttatt tttatatttt
    43801 tgaaaaaata tttgaaacaa aaaaaatatg ggagcatacg aaaatatatc ggttatatat
    43861 ataaaaaata cgtttatata tgaattatat agttctaaat ataaaaaaag ttaaagtcct
    43921 accgtaaaaa agcgcatttt gaataagata acaaatatga taaaattggt cttgttgaaa
    43981 tttttagggg ggatatgatg acaaagaaac tagtaatatc aaaaacaaag ttgtttattt
    44041 ttataatagc atttatttct atatttatat atttatttgg aagtaaaaat acacttatag
    44101 gtgtaggtat agtaacagct atgctaacgc tcttggaaag agatttaact atttctccaa
    44161 ttaaaaattt actgaagtat ttagcaataa atataatctt aggaatacta tcattttttg
    44221 cagtacaaaa tatgtattta ggagttttat taaattttat agcattattt ataatagggt
    44281 atgtatttag ttatgactta aaaagagcag tatatgtacc ctttggtcta atgtatatat
    44341 ttatggtaag tatacctgta ggaaaaagtg aatttcctat gagattgtcg gctttagctg
    44401 ttggagcagt tataataatg attgctcaat ttgttatgaa tagaaatagg atgaaaaatg
    44461 tcggagataa agaactgata tctatatgtg atgaattatt agaaaaaatt agtcttttaa
    44521 aaaatactat taatgatgat agttctataa ttaaatctag tatgagaaaa atagatagct
    44581 gtaattatag aataaattct atatctaaaa atttgaaaat ggttattttt gataatagaa
    44641 aagatgactt ttatatcagt attagaggta tagacataat gaatatttta ttttcattag
    44701 aaagaataag tttaatccta gaaagataca aaaaggatag taaagaattt gaagatgaag
    44761 atataaaaaa tattttagaa gaaagtagca taaatagtaa atcagatgtt ctagttgtag
    44821 caacgaaaga aataaactat attaagatgt gtttagaaaa taaagatacc ataactgata
    44881 aagagatatt aggatttaga gattatgtta ttgctcagga tactaaaaat ataaatttaa
    44941 aagaaattta tagtgtttta gaaaatttat atgagttttt agtagattat aaaaaagtaa
    45001 aatcaagaga cgaaaagaaa gctgaaagaa aatcaaagat acctcatgaa tttaaacgac
    45061 tatcaatata taagaaaaac tttaatttaa attctataag attttcttat gcagtaaaga
    45121 ttgctttagc tacagctgta gcgggtttta ttatggatta tttccattta agagatggaa
    45181 gatggataat gttaactgtc ttttcattaa cacaacctta cgcagaaaat tgtatacaaa
    45241 ggtctagaaa aagaatagaa ggtacattta taggagctgt aatatttatt gtattatttt
    45301 caataataaa agatagtaca ttaaggtcgt taatagttct tttagcaggg tatataaact
    45361 cttatgtagt tgattataga aaattaatgg tatgtgtaac tgtttcagct cttggttcag
    45421 cagtagttat gggagaccca aatgttttaa ccataagcag gatttcatat gtagcattag
    45481 gagcaattat tgcattaata gtaaataagt ttatattacc atatgatgct aaaacaggct
    45541 atcaacatgt tatagaaatg tataaaggaa tagttaaaaa tataattgat gaagtcaata
    45601 agtctataga aaatgtagct gatgtttact atataaaaaa tttattattg ataccatcac
    45661 ttattgaaga tagacttatg ttgataaatg ctatatataa agataaacat caagaggatt
    45721 ttttagaaaa tcagaaatta ctaataagta atatgtataa tctatatata aatgttaata
    45781 aaaataaaat aaaagatgaa gatgttgaaa aaatattgag agatactaat tatatttcaa
    45841 attacaatgt agataagtat gatgaaggaa gaagtgtaat tttagagagt attataaata
    45901 ctaaaagtct aggtgacaag ataatatgtc taaacttact gcaaactcta aatggtgtca
    45961 aagaaatgta tagaataagt aatataacta aagtttcaat aaaagaagca gcttagatat
    46021 taaattatag aatagccata tatttaaaat aaagtatatg gctatttgtt ttataaaata
    46081 ctaaaagaaa ataatatata aaaaacaaaa aacatatatt tatgaatttt atatgaaaat
    46141 agttaaaata ttgatttttt tcattggttg aaaaaacaat ttacttagga taaactataa
    46201 tagtattcaa atattatggg ggttagattt atgagtaaag atgtaaaggt aaagcgtaat
    46261 aagaaatatg atacatttag tataactatg gaacttgaga gacctttact ttatgatgag
    46321 gttgagaaca aagatgataa aaataataat agaaaattta acataaagaa taagatattt
    46381 aagggaatag gtatactatt tgtattgatt ttgcttggct ttttcatatg gataaataaa
    46441 acatatgaac ctcaaaagct ggcaaaagaa gctctagtca gcaatagtaa agttgaagta
    46501 actgtaaatg aaaacatttc atttacacca aaaggaagaa aagtttctaa aggtttaatt
    46561 ttgtatccag gagctaaagt agaaatagaa tcttatgctc cacttgcaag aaaaatagca
    46621 gaaagtggat atgaagttgt aatcgtaaag atgccactta atctagctat acttggaact
    46681 aataaggcac agaaagttat ggattcttac aacaacatag aacattgggt aataggaggt
    46741 cattcattag gaggagttgc agcatcaaat tttgcacgtg ataataaatt aattgaaggc
    46801 gttgtatttt tagcttctta tccaatgggt gatgagttga aagaattagg aaaaaaagtt
    46861 atatctatat gggggagcaa agatggagta gtcaatttta aaagtcttgt agaatcaaaa
    46921 caaaaacttc ctgatgatac aacttatgtt gagattgaag gaggaaatca tgcacaattt
    46981 ggagattatg gaaaacaaaa gggagataat gatgctatta taagtcaaga aaaacaactt
    47041 aatattactg ccaatagtat cattaaattt ttaaagaata tatcttaaac taaaatttaa
    47101 aaaatataat tttataagtt attatttaaa gtaaatatta ataatataat agaatgaata
    47161 ttttattaca agggggattt taatatggaa tacgatatgc cactttacag accaccaagt
    47221 gaggcttata gtcttataat acaagtcaca ctaggatgtt ctcataacaa atgtacgttt
    47281 tgtagtatgt acaaatctaa aaaatttaaa ataaagccac tagaagtaat aaaaaatgaa
    47341 attgatatat ttagaagata ttataagcat gtagaaagaa tattcttagc agatggagat
    47401 gcattgataa taccaatgga gaaattaaga gatattattt tatatataaa agaagttttt
    47461 ccagagtgtg aaagaattac tatgtacggc tctcctaaat ctatagagaa aaaatctgat
    47521 gatgaactta aagaattaag aaaacttggt gttaaaatga tttatctagg gcttgaaagt
    47581 ggaagcaatg aagtattaga agatattaag aaaggtttta gtagtgaaca attaataaaa
    47641 gttggtagaa aagttaaaaa aagtgggatt aaattatcag ccactgtaat agcaggtctt
    47701 ggaggaacta aaaaaacaca tcagcatgca gttgatacag gaaaaatgct aggagcaatt
    47761 tcaccagatt atgtgggtgt acttagttta atggtagaac ctaatactga actttacgat
    47821 ttacttaagg caggagagtt tacaatacta gaggataagg ctgtgttaca agaaattaaa
    47881 gagatgataa agaatataga tgctaatgaa aaaattgtat ttagaagtaa tcatgcatca
    47941 aattatgcta atttaaaagg tgtattacct gatgataaac aacgtctaat tgatgaaatt
    48001 gattactatc taagtaacca aaagctaaaa agagaagaat atagaagact atagtttttg
    48061 atatatcaat ctatactgat aggtaaatac taagattatt tagatacaaa aaatcatgct
    48121 acattaatag ttgcttacta ttgatgtagc atgatttttt attaaaaaac aaaatggtat
    48181 attcatatat aatatatcaa taataatgaa aatgtgaact agtttaatag aattttacct
    48241 attataataa aaacaggaat ttaaataata aaaagtaaag taacttttta ttaagtaact
    48301 ttacttttta ttttatttaa tgttgtatta aatttatata tattaaaata atatacaaat
    48361 tttgaaaaag ctcttataaa atgattatta aagtaaagtt taatataaat aaattataaa
    48421 atattaaact aatttatcaa tatttcctga ttgaatatgc ttaatgtttg attgaatttt
    48481 tttatatggc caatcccacc atttaatttc taataatttt gaaattgtat cattattaaa
    48541 tctctttttt ataatttttg caggtactcc tccaacaata gaatacggtg gaacgtcatt
    48601 agtaactact gctcttgttc caataattgc accatcacca atatttacac ctgacataat
    48661 tatagaatca taacctatcc acacatcatt tccaattata atgttaccct tattgtccca
    48721 agcgtccgtt atatggttga tatcgagttt ccattcttca taaaagatgg gaaaagtata
    48781 tgtggatttt gatttcattg agtgatttcc actagtcatt agaaattttg cattacatgc
    48841 tattgagcaa aacttaccaa ttattaattt atcattgttt atagggtaat gatacaatac
    48901 attgtttttc tcaaaatctc ttgggtcatt ataaaagtca ttatatattg tgtaatctcc
    48961 aacttctata ttttcccttg ttattacatt tttaagatat acagtttgat aatcattact
    49021 tcttggatat accttatttg aacttggaat agtcatattt aaatctctcc tttaatatat
    49081 attatgtttt tgactattcc actactacaa tacatctctt cacagaatca ctccttgtta
    49141 agaatcttca taagataatg gcgtcctttt ttagtgttaa gtcggatatt ctttcttagt
    49201 ccattctttt tagcgtataa ctgacaaact gtcattttct taccaatagt gtcaatgcta
    49261 tcatcaaggt cattttgtat tgctttttcc ttatccctta atgatatatc atcacgtttt
    49321 ccctttgggg gtttatcagt aggtacaagt ttccaagagt aaacaaattg tggtttacca
    49381 aatgaatata catacttata tgcgtatctt ccatcttttc tctggctctc tccagttctt
    49441 aaaattctat ctttattatc tcgtcttttt tcagttgaca tgataagaag ctcctctcaa
    49501 taaccgaatt gagcttgata cgtcatatga atattataac atataaggct caatttcatt
    49561 agataacgtc aagtgtatca acgattttct caaattgttt tctctttatt tgaatgcgat
    49621 tgctattcat aatgacccag ccagaatcaa ggttttcatc agcacgttta cgtaattttt
    49681 tctctccaat acgaaagtat tttgacgctt cttcaatcgt caaggtatat ttttcccaaa
    49741 taggtacatc agtattgttc atataatgta tcactccttt ctatgttcgt agttcagaag
    49801 tagatagatg gctttgataa gctccattgg tatttcaacc aatcccattc ttatggacag
    49861 aaccgtgtca tacaggtgta tcattatact gtggtacagg ttacggcaaa acaaccgttc
    49921 caaaggttat tcacaaatca ctatatagta gctctcttga ttaaggtcat ggcgtatagt
    49981 atttgttggc tatctgtatc acaaacgtat ctatctactt tattcagttg tcaaagaaca
    50041 gtcggcattg atttgcctat aaaaaatcac aatagcttgt gggcttttat agacaaataa
    50101 ttagtgattc tccatgtacc aaatagcttg atacatggag agagggcgag attaagacaa
    50161 attaaatctc aaaatagcag tgattagttt tgttcctagc attcgctttg tttcttcttc
    50221 tacatgaata tagggatttc cgtattcatc aaataaagtt ttctgtgaaa gacgaatgat
    50281 atagtgttca aaatgtttaa gtattacgtt tattgcattt acatcgccat gtacagcaag
    50341 taaaataatt gtaaaaggta atacttcttt agtaggtttc atttcaatgt tcctgcatga
    50401 gttctttcaa ctcttttagt gcatttgttt tgtgataatg tatggtattt tctgctaaat
    50461 ccatcaatgt tgctatgtca gcatttgtca tgttgaaaaa gaatgaaagt agaattatat
    50521 cttgttttct ttttgtaagt tttccgattg cttgcgccat taatacatct tcaattcgta
    50581 tgttgtagtc gtaagaaacc atacagatgt agttagaatc ataatcatct aaaatactca
    50641 atttacttaa ttctgcaagt gacaaagatt cgagagatac caaataatca tttctgcgtt
    50701 tattttcgtc ataaatatct ctagcatagt tacgcaaaac tgttttacag aaactgtcga
    50761 attgatgttc aattgtcttt tcatcaacca taagatttca ccctctttcc atcgcaagga
    50821 gttaaataac cttgcttact cctatcacgg tgggagggcg ttaaatcttc gataaatttc
    50881 aaaaaaaaga gaaaaaaata cacactctgc ctatagggca aaaatgtgta ttctttaaaa
    50941 cgtatttaat ttatattggt tgtaagccac caccatattg atgtatggaa atatgcattg
    51001 gctagctttt cataaaaata caaagatgca taagaaatta atagagggga aaaacttatt
    51061 ctgttattaa aaagtaggtt aattctaata aatgctattg cggtcgaatt aaactatata
    51121 catggcaatc aatcatgttt ctattcttta ttatgaattg tgacagtatt cttcaatctt
    51181 aaagccacat ttttccaata ctttacttga ctctctattg taggaatata cattagcatg
    51241 aattttgtta aggttgtatt tttcaaaggc aattttgcat atttctttta ctgcatttgt
    51301 tgctatccct ttgcctcaat agttcctagc aagccagtaa cctaattcag catttttatt
    51361 aatagaggta tcttcttcaa atgttaggct gatacttcca atagcccttt cttgataaaa
    51421 aatagcatag ctaagttgtt taacatctga agttgccaaa caaaaactaa caaaatctct
    51481 agcgttttgc tccctataag ggtgggggaa gttgtcacga agattctttg caatttcttt
    51541 atcattcgca aactcaacta aatcggtaat ataagcataa ttccactcta taagttccat
    51601 ttttcttctc cttttatgaa acagctacaa gaaatctttc taagccaata ccacttatca
    51661 aacagcgttc tcttttattt ccaagcattt gataagtcca gtcaacaaat ccaccgtcaa
    51721 ctatttcaac ggtttcattt ccttgtttga ccgataattt gaaattgata cctttataat
    51781 aattattatc aacatcatca ttatgaattg ataactctat attaggaaaa ataagtttga
    51841 tagtttcaac cattctgtcg aaaaatccgt cattatcttt gtatccgttt cttttgcgta
    51901 gaataataga gaaacgaaca ttttctattt cacttaatat atctttataa tagtttaagt
    51961 gcttttctaa caacattttt tcacaagtgt aagaccctgt atctatacca gatgaaacca
    52021 tacaatataa gccaaaatgt gaatataaac ctttacctac aaaattttgt gctcttatta
    52081 ccctagcagt agtagccatg tggataggta tggtattatt ttcttctttt ctttttaatt
    52141 tatcagcaat aattattgcc aacatatttg aggggtctgc aagtgtttct gtccctcgta
    52201 gagcacttac tacgttatat tgatctacgg agccaaaaac gctacagcta cctaatgggg
    52261 cagagggaga aagcataatc gtcttgatat ccatattgaa tgcttttctc aataattttg
    52321 attccaaagc atgaatttct tctggatcta taccgctagg gatagtaaat ctatttagtt
    52381 ggtatgactt tagaatatca gttgcagtta aagtatttgc ttgtctatca aacacttcta
    52441 atagaagtga gttcaaatct gattttgata gagctgataa cttatcaact atattcttat
    52501 ccccaatttt atttgtaatt ctacttaaaa tatcactcat agttatcctc catactgtta
    52561 ctttcaaaat aattatagaa ttgttacaac aactaatcta ggtcatttga ccaaaaatga
    52621 aaaaacactg aatatttact attcaatatt tttttacttt gggtttattt gattaaatct
    52681 tgaaaatact gtaatgcaac cctttcagct tcaacctttc ggacaatagg actttgtgat
    52741 aattcctctc ttaactcaag atacaggttg atagtagcct gcaatgcatt aacacagctt
    52801 ttatattcat ggttagcaac cgtcttttct aatgcttcaa tatattgggg tgcgtccaat
    52861 tcaatttttc taactccacg aggtaattta cctaagagaa gctgtattaa tggggcaagt
    52921 actgattgtc ttaaaaaaga taaaaaatca attgtttcaa atagttctct acgtccaatc
    52981 ttagtgcaag cgtaatgaac ccaaatccaa aatctatctt caatccactg taagtctgga
    53041 gttgggaagt atgcttcttt tttagaataa atttctgtta tgcagttgtt ttcttcatag
    53101 agaatagctg aatcttcaac cctatctagt aaaccatcta aggttgtaaa cttaaaatca
    53161 acatgaagaa caggggaatc atagagggaa attatcaatc gaggttctcc aacgtgttcg
    53221 ccagtaaaag cagaaactaa tgttccaaac tgttccacaa taagtaatct ctcttcgata
    53281 acttcttcat aggatttatc atctgctaca atcagaaaat ccaaatcaga atattcatct
    53341 aacgattttg tgatataaga actgctaatt gcaagtccta ttatcctact atctcttttt
    53401 gaaaattcta atacgttttg tatcattttc tgttgtgttt tagtcataat ataacacctc
    53461 tcactgtctt ttattagcta tcaatccaac ataattatgc ataggagtat tatataatga
    53521 agaaataaaa aaaaataggt cacttgaccc gaaataaaaa agcattgaat aattattatt
    53581 caatactttt ttgaaattat acttatgttg taggaagatt ctttaatacc tctcgctgat
    53641 taattacact aaatcttttg ttttcataag caattagatg ttcttgtaca cattcattta
    53701 tagcacgatt aatgcttcta attggagcgt ttacttcgct agcaagctgt tttttggtaa
    53761 gcagatttaa ttcacttcta taatagtgta aggatataca cctcagaagt cgttctttaa
    53821 cacttaaaga tgataattct tcaattaatt cagcatttac aactaattta ctagatattt
    53881 ctcgaatcag aaattttgta gcttcaaaat ctccccttaa ccagtttaaa aaatcatctc
    53941 tatgaagttt atatacatta caatctgtga aagcgacaat ttcaacgggt tttttcccat
    54001 cattaaattg ttccatttct ccaaaaaaac taccacttct ataaagatga atcgttgaga
    54061 tgtttccttt cacatttaag atgaatgctt ctgcaatacc gtcaatcata agaattacat
    54121 attcattttc ttgctcagca aaaagaatag tctctttctt tttatacgtt tttttaacaa
    54181 gcttcttttt aatatcttca ttcataaaat caattaaatg catattcatc cctccttacc
    54241 aaatctttga ttaaattata tcatctttca attagttagg taagatagta aaaatatatt
    54301 tacatagaaa ctattccatt attattttcc agttgtcatt tttctgcaaa aacttatcac
    54361 tgtcacgact ggagatacca gtaaggaatg ttaggatatc aatcgctaaa ctttcagaat
    54421 cctttttacg gctcaaaatg acgtaagggt caagcaatcc tttgttttca tcattactgg
    54481 ttaaattgac aatgtttatc tcatgggcta tttctggtag cgtttctttc catttgccgc
    54541 gttctgcttt agggtcaact atgaccgcct gtccgccgaa tagtaccgca tagtaaacaa
    54601 gcatattgtt actgaataat ttaccaccac ccaatgaacc gataaacgca gacgctaacg
    54661 cattggtaat agaacccttt accccttgac tagcaagggc aggttttaga tagacattct
    54721 ttccagtgtc cagattgtag ccaagataga tatcctcatg ttcgccaagg gtttgtgtcg
    54781 ctccaaaacc aagtccagcc aaaaaatccg aagtgacata ttgaatataa tcattgatgt
    54841 aacgtttgct gacaggaata aattcgccat gcaatcccaa catatcccca aagggacgca
    54901 cgagcttgat tgataagtcg tcgtaaaagt ctttgacttc atcacaacgc ctttttagct
    54961 cgtcaagatt ctttgtagat acacggacaa catagctaag tttatacata gattctttac
    55021 agttaaaagt ctgtttttaa aaaaatgtat aaattataaa tcaaaatata gatactatca
    55081 atgacccact aggtgcaaaa agcattgata tggttaaatt atcagacgct aaaagctggg
    55141 ctatccgaat gagtgaagat gggtgtgctt ataaatccat tgacaattat aagcgctcac
    55201 tgaaagcgtc gtttttcatg gcaattcaag acgactgtat tagaaagaat ccatttaatt
    55261 tttagttaag tgatgttttg gaagatacaa cagaaccaaa aatcgctcta acaccagaac
    55321 aggaaatggg cttattatcc tttatgggga gcgataagac ttattgtaaa tattatgatg
    55381 atgttgttat cctcttagaa acaggactac gcatttctga attatgcggt ttgactttag
    55441 aattggatat gaaaaataaa gccattatgg tagaccatca attgttgagt gatactaaga
    55501 ttggctatta tgtagaagtt ccaaagacca cacagggtaa gcgagaaatt ccaatgactg
    55561 aaagagctta tcaatcattt gaacgtatcg tggaacggcg taagaacgct aaagcagaac
    55621 caatcattgt tgatggttac cagaacttcc tatttcttaa acaagatgga ttaccaaaac
    55681 aagcaactca ttatcaaagc atgttaagag cgttagtcaa gaagtataat aagacccatg
    55741 aggacaagct accaaagatt acgccacata cctttaggca tacactctgt acaaatatgg
    55801 ctaacaaagg aatgagtcct aatatattgc aatatattat ggggcataaa aacattacta
    55861 tgacgcttgg ctattatgca catggttcat ttagttcttc gagagctgaa atggaacggt
    55921 tataatccta gtagtatgac tagagtttac tacttattta ctacttttga tggcattctt
    55981 atacggttaa atgccaactt atgcaaagta tcttccaaaa agaaaatgcc gatactcctt
    56041 gtagatacag gatatatcga catttaccaa cttatgaaaa gataatcaaa tttaatataa
    56101 gtttttcaaa taaaaagata ccaaattctt tttcgagaat ctatataaca ttacttaagc
    56161 ttggttgggg tataaacaat tgagtagcta cttttgtatg gtgttcaact ttagtcaaaa
    56221 ctcttaagta atgcaaatga tttagattca ttaatattca atctcttcat aagtagtgaa
    56281 attcgagtta tttctgcata attatactat gatttataga ttaattctat tagcatccag
    56341 aataatattg tttatatgag taaaatttaa agaatattgt gaaaattata ggatgttaaa
    56401 ataaatttag gtaaaaaaga agtgtttgta tattatagag taccttttct aaaatatgtg
    56461 ggattgtttt aagaattaga ataaaaatta tttttaaatt agtattttta taatgtatag
    56521 tatttttaat gtataattaa attgtgcaga aaatagaatt taaagtccta tagaatttct
    56581 gattatggag gagaatatga aaagaaaagt tcaagtaaaa aatattacta ttggagaagg
    56641 tagacctaaa atttgtgtac caattattgg gaaaaataaa aaagatatta taaaagaggc
    56701 taaagagtta aaagatgcat gtttggatat tatagagtgg cgagttgatt tttttgagaa
    56761 tgtagaaaat attaaagaag ttaaggaagt tctctatgaa ttaagaagtt atatacatga
    56821 tatcccttta ttattcacat ttagaagtgt agtagaaggg ggagaaaaat taatatcaag
    56881 agattattat actactttga ataaagaaat ttctaataca ggtttagtag atttaataga
    56941 tgtagagtta tttatgggag atgaggtcat agatgaagta gttaattttg ctcataaaaa
    57001 agaagtgaaa gtaattatat ctaatcatga ttttaataaa actccaaaaa aagaagagat
    57061 tgtatctcgt ttatgtagaa tgcaggaatt gggcgcagat ttacccaaaa tagctgttat
    57121 gccgcaaaat gaaaaagatg tgttagtgct acttgaagct acaaatgaaa tgtttaaaat
    57181 ttatgcagat agaccaataa taacaatgtc aatgtcagga atgggtgtta taagtagatt
    57241 gtgtggtgaa atatttggtt ctgcattgac ttttggagct gcaaaaagtg tttcagcacc
    57301 agggcaaata tcatttaaag agttaaattc agtacttaat ctattacata agagtattaa
    57361 ttaaattaat tatatagaaa tattagacgg tatttttgaa gatataaatt aaatataaaa
    57421 aacttttcag atagtaaaat ttaaattggg caattatatc tgaaaagcaa ctatttagtg
    57481 tgtattttga aagtgatata gaaaatctta taaatcaact atggcatatt taaaatatgc
    57541 cattaaaacc tactagacat tagattatag atggtatact agcatttcta ttatttatag
    57601 atagtaagtt ttcataataa ctgttttatc taaagtagaa gatatatttg tattatgtat
    57661 atttgtcatt atttttttgt aattatgtat attaatggtt atatatgtaa tataatatta
    57721 tcactctatt ttttgtatat tgtacattac aacatttata tctatcatca tcaattacag
    57781 tagaatgtat gggatactta ttttcactta accaatattt ttgcatattc tttgtccaag
    57841 actttggaaa cttcaatact ttcttgttta ttataacatc ctcatcttca aaaatattaa
    57901 cttctctttc tatttttatt tttctgttgt atatcttatt gatagattct ttgtcgagtt
    57961 ttatgtctct atacatatca gggcaatagc aacaaacata atttcttttt tttcgacgtt
    58021 taaatttcac aactttctct atgctaattt ctaatttttt tgtaccatct tttataaatt
    58081 taatatcttc tatgttctcg cttgaaaaaa tttctgtcaa tcttaaagta tctacagttt
    58141 ctctaattat ttgcttttta taagaagaga atccatatcc aaaagaaagg tttaatttat
    58201 tagggatgta gccattttta tatttaaaca tcttaatttt ttccaattca gcattatctt
    58261 taaatttcaa cttttcatac ctaaaagtta ctttgctaaa aagagtatat tctacatcaa
    58321 tatattcttt tgcaatctta aatttatcgc taccttcaat cacaatcata gcctatctcc
    58381 aatcgtttta tattaaaata aggccataga acatggtcta atagtactca ttagcactat
    58441 aagacaatgt taacacaaaa agacaaaaaa aggttattta tttcaaataa cctttttttt
    58501 tatataaaat ataaagaatt atattttatt cttttttatg atgtctataa tctgtgatat
    58561 cagatttagt tctcttgaat ttaagtcttt taactcttca tttatatcat tttctaaata
    58621 tgtttttcca gtggaagtaa tatcttttat aagaacatct gcagaaatat ttaatatatt
    58681 tacaaatttt atgaatgttt taagacttgg attcttttta ccactttcga tttgagttat
    58741 ataccaaggc gatactccaa ccatatttgc aaattctttt gaagttaaat ttgctttttt
    58801 ccgttcttct ttaagtcttt tacctatata attcattatt gttactattt ccctcactta
    58861 tatttctttg tatttaatga tgcactttat taactctagc attgcaattt gttctttttc
    58921 agttaattta ttaatcattt cataacattc taaaggtaca gagttatcaa cgccttctgt
    58981 tgtaataata tttgcaaata acaattcaag tggtatgtct aaagcagtag caattttcat
    59041 tataatattg atagatgtat ttgtctcagc tctttcaatc tgaccaatat atgttggatg
    59101 taaacctgcc ttttctgcta gaaactcttg actatatccc aattttgttc tatagacttt
    59161 tattctatct cctattattt ttcctatatt tgccaattat tatccctcca ctttagatta
    59221 tattcatagt ttaagttgtt ttatatagac tatttatact tttttagtct aaatatagac
    59281 tatatatgtt tttatactga aataagtgct atttattttt gtatagtctg tatctacaat
    59341 aaacaaatat ggataaatca tatttttaat tagagaaata ttttcataat ttcatagcca
    59401 tactacaata ataaaacgaa ttaataatat gttaattata gcatttttta ttgtaattac
    59461 atattagata tgtagaatat attttgaaaa ttaaaaaaat tttctatttt atatattgaa
    59521 caattt
//
LOCUS       DAEHWM010000012        58212 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.013, whole genome shotgun sequence.
ACCESSION   DAEHWM010000012 DAEHWM010000000
VERSION     DAEHWM010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 58212)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 58212)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..58212
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.013"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            215..1258
                     /gene="holA"
                     /locus_tag="KNP36_000791"
     CDS             215..1258
                     /gene="holA"
                     /locus_tag="KNP36_000791"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HBF0872680.1"
                     /translation="MNYKDIIRNVKEKNFEKMYLFYGREYYLIENAIKAFKDSLNEGM
                     LDFNLDIIDGKEIVLNQLISSIETLPFMDDRKIVIIKDFELLKGKKKNFTDSDEKYLI
                     EHLDNIPDTTTIVFVVYGDVDKRKSLVKKIGNNGIVFDCDKLSDMDLFKWIKKSFALN
                     DVIIDNSQIMYFIEQEGYRDKSSEKTLSDLENEINKISSFVGKGNNVTNDVIDKLSQK
                     KVENDIFKLIDYIGEQNASNAMKILNDMIQEGESVLGIFSMIARQFKIIMQVRQLQLD
                     GYSTKLIADKLKMHQFVVGKALKQTKNFSDDIIVEILNYILESDYKIKTGLIRDTLAV
                     EMLVSRYCKREAI"
     gene            complement(1445..1711)
                     /gene="rpsT"
                     /locus_tag="KNP36_000792"
     CDS             complement(1445..1711)
                     /gene="rpsT"
                     /locus_tag="KNP36_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HBF0872681.1"
                     /translation="MANIKSAKKRISVIEKKTALNRVRKSQIKTAIRRFEDAVAAGNR
                     EDAVAKFQYAQKRIYQVASKGTIHKNAAARKVAKLAQKLNGMNA"
     gene            2289..2810
                     /locus_tag="KNP36_000793"
     CDS             2289..2810
                     /locus_tag="KNP36_000793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872682.1"
                     /translation="MDIAKLILNPARLRILQYIRLYGSVRTSDIVKYLNDIPRATVYH
                     HVKILEENNMIEVIKENRVRGTIEKVYALKEYTTSMEGETFVALSTAFYVGLMQEMNE
                     YFSRKEQDHKKDNVFFSSALLYMSDNEYENLLKSIADLLKPYIEQKPKSNLKLRKLSI
                     ISSPPVADNDKTK"
     gene            2844..3620
                     /locus_tag="KNP36_000794"
     CDS             2844..3620
                     /locus_tag="KNP36_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0872683.1"
                     /translation="MKFHEFGNKNRPHIMLIHGGGNAWWNYLRQAEVLSNKYHVILPT
                     LDGHGEEYETTYISTEDTADKLISYIDENCSGHLFALCGVSLGGQIVMELLSRKPNIT
                     KKAIIDGSICYPRPLMARFCIAGIRFFGGLLFSEKACRFQIAMMPKLLPENMQYPDKI
                     KAYYMTDMPHVRKETFYNMYRTYMMNYTLKENVKKTTAQVMYWYGEKEMKCVKKSAKL
                     FQSYVPSCEIYEAKSYNHGYLSLYLPNEWLEIAEPFFQKE"
     gene            3962..4915
                     /locus_tag="KNP36_000795"
     CDS             3962..4915
                     /locus_tag="KNP36_000795"
                     /EC_number="3.4.24.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GPR endopeptidase"
                     /protein_id="HBF0872684.1"
                     /translation="MISVRTDLALEASEMCEKSQEGSSIPGVKIETKELENCIVTKVE
                     VIDRQGAEIMNKDIGKYITLESNLMKFDDDESREEMISYLKEELVDIFGQDKNKKTLV
                     IGLGNRNITSDALGPKSVSKTLVTRHLFKNYNKDYDDDFTEVSALSPGVMGVTGIETS
                     EIVKSLVEKVKPDRVVAIDALASRKMERVNSTIQISTAGISPGGGVGNTRKSLTKETL
                     GVDVIAIGVPTVVDAATLTIDVLDMAIDNLIAQSEETESFYEMLKKLKEEEKYHLIKD
                     SLDPYDKNLIVTPKDIDDTIENLSIIISEGLNRSLHPGRLV"
     gene            4933..5952
                     /locus_tag="KNP36_000796"
     CDS             4933..5952
                     /locus_tag="KNP36_000796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein P"
                     /protein_id="HBF0872685.1"
                     /translation="MFKKCIKVVTLTFILVCILPGKSLALNQDDFLKFLVNSSYPEAK
                     VEGNDTENKKNNKNKETSKENKEESKEGNTKSKDASKVDNKKESEKEYIKLYVGKENV
                     PDIESKNSDTTETNTTSSSDYKDDLRVTKENPRILIYHTHGCETYSNSPDGNYHSRDK
                     KNSVMEVGSALTSALDSKGWGVVHTTKYHDYPSYNNSYASSLKTIQSILPKYNSVDIA
                     IDLHRDARDLTNPATKEKDHLKYTTMINGERVSKFFFVVGGKNTNRKQLRALAEDITA
                     FAEKKYPGLVSPIVEKDYARFNQFAVKNHMLVEIGNNATSVEESKATTKYLAEILDEY
                     FKQKN"
     gene            5983..6234
                     /locus_tag="KNP36_000797"
     CDS             5983..6234
                     /locus_tag="KNP36_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872686.1"
                     /translation="MSRLEKNIESKSKLRKYKYIMRILFLITMIICTSVCVFIVDSNA
                     KSMLGMKQYDFPSIKFDITKFDFDIPNFDIHEIIKKFNK"
     gene            6516..8321
                     /gene="lepA"
                     /locus_tag="KNP36_000798"
     CDS             6516..8321
                     /gene="lepA"
                     /locus_tag="KNP36_000798"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HBF0872687.1"
                     /translation="MDNKQSRTRNFSIIAHIDHGKSTLADRLIQQTGLVSERDMKSQL
                     LDNMDLERERGITIKLQNIRLMYKAKDGNEYYLNLIDTPGHVDFNYEVSRSLAACEGA
                     LLVVDAAQGVEAQTLANVYLAIDQDLEILPIINKIDLPSARPEEVKNEIEDLIGLDSS
                     EAPLISAKTGLNIEDVLEDIVKNVPPPKGDNEAPLKALIFDSYYDAYKGVVAYVRVFE
                     GTVKKGMTIKMMNTNKKFEVTEVGVMAPGQTELSELSAGDVGYIAASIKDIRSCRVGD
                     TITDSNNPTEEPLPGYKKATPMVYCGIYPGEGEKYENVRDALEKLQVNDAALEYEAET
                     SAALGFGFRCGFLGLLHMEIMQERLEREFNLDIITTAPSVIYRVTKMDGEVVMIQNPA
                     NLPEPSEIKMIEEPIVKGDIIVPKDYVGVVMELCQERRGNMLNMEYIDDRRVMLHYDL
                     PLNEVVYDFFDALKSRTRGYGSLDYEVKGYVASTLVKLDILINKEQVDALSFIVHETR
                     AFPRGKAMCEKLKGEIPRHQFAIPIQAAVGNKVIARETISALRKDVLAKCYGGDISRK
                     KKLLEKQKEGKKRMRQIGSVEVPQKAFMSVLKLDE"
     gene            8470..9807
                     /locus_tag="KNP36_000799"
     CDS             8470..9807
                     /locus_tag="KNP36_000799"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HBF0872688.1"
                     /translation="MINIEIPKKVDYIIKELEKNGYEAYIVGGCVRDCLLERVPNDWD
                     ITTSARPEVVVELFEKTIPTGIQHGTVTVMIEHEPFEVTTYRIDGNYSDGRHPDSIEF
                     TNNIVKDLSRRDFTINSIAYNSKTGLVDPFNGYEDIQNKYIRCVGNPVDRFEEDALRM
                     LRAVRFSAQLNFKIAEGTKQSIHKKADLIKNVSIERIQTEFNKILVSDSSKLNLLKST
                     GLLKFIIPEICELEDVTQHNPYHIYDVQKHTLIATEVIEDELYLKLTMLFHDLGKKVT
                     KTTDKNGVDHFYTHSRESVKIAKKILKRLKYDNYTINKVLILIQYHDYRIEPKRKIIK
                     KLLNKLEDVELFEDLIKVNWADTLAKNPKYAKQKILNLIECEKEFKHIINQKECFNLK
                     DLAINGKDLISIGIKPGKDIGYILNKMLEIVINNPELNEKEILKEKALNIYTF"
     gene            10040..11353
                     /locus_tag="KNP36_000800"
     CDS             10040..11353
                     /locus_tag="KNP36_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0872689.1"
                     /translation="MHTQLQKTIGLSAALSTVVGMVIGSGVFFKPQAIYTTTNGAPGL
                     GIIAWLLGGFITITAGLTATEISAAIPKTGGMMIYIEEIYGEKLGFLTGWMQTVLFFP
                     GTSAALGVIFAQQASELLGMSPNNMANVLPIAIGVILFLALLNIIGSSLGGKVQTVAT
                     IGKMIPLILIIVFGFIKGQSSEVLNPFVGDGVNASNALGQVLIATLFAYDGWINVGAI
                     SGEMKSPEKDLPRAIVGGLSLVMAVYIIINIAYLWVVPASELATVTSPATLVATRLFG
                     NIGGKVITVGILISVFGTLNGYLLTGSRIPYTLAEMGTLPASKTLLKVNSGGSPVNSI
                     LLITVLACVYALSGQFNLLTDLTIFSIWVFYVLTFIGVMRLRRQKPDLHRPYKVPLYP
                     IIPIIAILGGLFVIINQILTSTVISLGGIFITLLGLPVYYYMKKR"
     gene            11525..12700
                     /locus_tag="KNP36_000801"
     CDS             11525..12700
                     /locus_tag="KNP36_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HBF0872690.1"
                     /translation="MLGLYVHIPFCVKKCKYCDFNSYKMDIDSKKRYIEDLKIEMELY
                     SNKLYKDNKYKNKECCSLNKNDKITSIFVGGGTPSILTSDEIREVFISIKEMFDIDEN
                     AEITIECNPGTLTLEKLKTMKEIGINRLSIGLQAIQEKHLNFIGRIHTYEEFEKNYKD
                     ALSVGFKNINIDLMYSLPNQTLCDWKETLEKVVHLNPTHISAYSLILEEGTELYNMYE
                     SNKFELIDENVDIEMYEYTINYLKSKGYNQYEISNYSKEGYNCEHNILYWECEHYIGI
                     GAGASGYINENRYNNVESLEDYHLSLVKREKPIQENEILSEKDMIEEKIFMGLRMNKG
                     IKFEDFKKKFGIDFREKYNKQIEMLLARKLINQSFEGIQLTQKGREISNSVFIEFME"
     gene            12803..13822
                     /gene="hrcA"
                     /locus_tag="KNP36_000802"
     CDS             12803..13822
                     /gene="hrcA"
                     /locus_tag="KNP36_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcription repressor HrcA"
                     /protein_id="HBF0872691.1"
                     /translation="MELNERKLNILKAIVKDYIETAEAIGSRTISKRHDLGVSAATIR
                     NEMADLEELGYLIQPHTSAGRVPSEKGYKLYVNSLMSKSELDDNDKILIEQCMNHNIN
                     HIKELIHETSKLLSQLTNYTTVAVTKSLINQSVIKHIQLVAMNDNNILLIVVTDKGDL
                     KKANLTTNVYLDQSKLNLISDNLTRKLLGKSITDLDDNLIAFIKYEISEYSGLIDELL
                     NALNSNMKEEDFSLSLNGATNIFSYPEFNDVLKAKSFLNMLEKKETIADIIKSKGIQK
                     DNLNIIIGSDNDCELAQDCSIVTATYNVDRDLVGRISFIGPTRMDYARIYSIINYMSL
                     LINRK"
     gene            13852..14472
                     /gene="grpE"
                     /locus_tag="KNP36_000803"
     CDS             13852..14472
                     /gene="grpE"
                     /locus_tag="KNP36_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HBF0872692.1"
                     /translation="MDKKNEQQEVREENDTSINQESETQVELEEEVVNEECETSSEKT
                     DEKEVDDENVTDINSKLAEKKLQDELDELNDKYQRLQAEYANYRRRTQQEKETIGVFA
                     NEKIITELIPVIDSMERALDACEDKEDTMYKGISLVHKQLIDTLVKFGVEEIEAESKE
                     FDPNLHLAVMQESVDGVEANQIVMVLQKGYKLGTKVVRPSMVKVSC"
     gene            14564..16411
                     /gene="dnaK"
                     /locus_tag="KNP36_000804"
     CDS             14564..16411
                     /gene="dnaK"
                     /locus_tag="KNP36_000804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000034699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HBF0872693.1"
                     /translation="MGKIIGIDLGTTNSCVAVLEGGEAQIIANSEGMRTTPSVVAFTK
                     DGERIVGEPAKRQAVTNADKTITSIKTHMGTDYKVNIDGKSYTPQEISAIILQKLKSD
                     AESYLGQTVTEAVITVPAYFTDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGMDKL
                     DQEKKILVFDLGGGTFDVSILEIGDGTFEVLATAGNNRLGGDDFDQIVIDYLAEEFKK
                     AEGVDLRNDKMALQRLKEAAEKAKKELSSTMSSNINLPFITATAEGPKHLNIDLSRAK
                     FEELTRGLVEKTMEPTKTALQDAGLSTGDIDDVLLVGGSTRIPAVQEAVKKFIGKEPH
                     KGINPDECVAAGASIQAGVLAGDVKDLLLLDVTPLSLGIETMGNVMTKIIERNTTIPT
                     KKSQIFSTAADNQTAVDIHVLQGERSMAYDNTTLGRFQLTDIPPAQRGIPQIEVTFDI
                     DANGIVNVSAKDLGTGKEQKITITSNTNLSEAEIEQKIKEAEMNAEADKQKKEKIEAF
                     NQAESTIYQTEKTLNELGDKISSGEKEDIEKAIADLKAVKDNQDATAEELKKATDEVM
                     TKFQKVSQEMYQKAAQEQQAAQGAEQAQDNGPKDDNVVDADFKEVDEDK"
     gene            16622..17776
                     /gene="dnaJ"
                     /locus_tag="KNP36_000805"
     CDS             16622..17776
                     /gene="dnaJ"
                     /locus_tag="KNP36_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HBF0872694.1"
                     /translation="MSTKRDYYEVLGISKGAEAQEIKKAYRKLAMKYHPDRNPGDKEA
                     EEKFKEINEAYEVLSDDTKRKTYDQFGHDGLNGQGGFGGQGGFGGQGFGGFEDMFGDI
                     FGDMFGGSFGGGRARRRGPQRGADIRQSVTISFEEAAFGKKMSIKVNRSEECEECNGT
                     GAKPGTSKKTCSTCNGTGQVRTVQRTPFGNIASSRPCSACNGTGEVIESPCSKCHGTG
                     NTRKVKTIEVDIPAGIDDGQMIKLSGQGEVGEKGAPRGDLYIVVNVKSHPLFTRDGND
                     IYFEMPITFVQATLGDEIEVPTLDGKVKYSVPEGTQTGTVFRLKEKGIPRIRGNSRGD
                     QYVKVVVEIPKKLNDKQKELLREFAKECGSNVHEKKKTFGQKIEDMFKKK"
     gene            18742..19677
                     /locus_tag="KNP36_000806"
     CDS             18742..19677
                     /locus_tag="KNP36_000806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBF0872695.1"
                     /translation="MYYIGVDIGGTGIQAGVVDNYGKIIFRSECKTVIEKGFEGILND
                     IKIMIYKLLEDNKLTMSDIKSIGFGVPGFINKEGLVTCVNLKWNKKAFNKELKRRFPD
                     VEIHGENDATVAALGEAKFGSMKGANVGVLYTLGTGVGGGIVINQKVFSGAHGLGSEI
                     GHQIIGENYFNCNCGNNGCVETFCSATAIIKYSQKLIEEGEKSRILDLAEGNLENVNA
                     KMVFDAYRENDLVAIKVINRFKEYLAKTFANTINSLDPEIISIGGGISKSSDIILDGI
                     EDLVRKFVLYKTEDIATITCATLGSDAGIIGAAFL"
     gene            19713..21086
                     /locus_tag="KNP36_000807"
     CDS             19713..21086
                     /locus_tag="KNP36_000807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0872696.1"
                     /translation="MGKTNARRTLFLIAIGSGTMLNPLNSSMISLALHSIQNDFHISF
                     TTVSWIVSAFYLASAIAQPVSGKIGDLIGRKVLFLSGLMLVILSASIVPLVQSFFILI
                     FIRVIQAIGTSTLYPSGVALIQNNIKERQSSALAVLTIFASTTAGLGPTLGGLLLDLG
                     GWHAIFLVNIPVVLVSICLGYFLFPKEVKEKKSIKETLKNVLSRLDIIGILLFSIAMI
                     FILLFLLSMKESFNLEQLVFGIILMCLFIWHELRTKLPFIDIKLFVSNPKLSKVYLQF
                     IILNFFNYILFFGLPSYFQDALHYSAKSTGLFMLFMSGIGIFISPLTGKWIDKSGTRF
                     PLVTSSIFMFISAVLLSVVFIHIPVIGKGIILSLAGISYGVGNVALQSSMFEESPRDS
                     IGTASGLFQTSRYLGSILATVLLGMVFEVNITSEQFQILGYVMVVLGTISFLLNFILK
                     KELRKVE"
     gene            complement(21274..22041)
                     /locus_tag="KNP36_000808"
     CDS             complement(21274..22041)
                     /locus_tag="KNP36_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872697.1"
                     /translation="MEELKDFLERQLNKKINIYPYENQKLDASSHLVTFNNAIYVIDF
                     LDKNNLDNLKGNFYLIYQSHIDFEYLKNIFYNLFEDINIIQHNGFFIVNSKYNLDINV
                     TTQNIIETETYQSTYIFYLGELDSKADFDFRLQLCSDLLPHIIKDNAENKFLNLFDFI
                     RYKTLDLINEDNILNKLIDFNKIKSIDEELLYTGIKFINNDLNISKTSTSMFLHRNTL
                     VYRLEKINEILGFDLKNFENAMIFYLSVKSYFLYKKI"
     gene            complement(22071..23180)
                     /gene="ugpC"
                     /locus_tag="KNP36_000809"
     CDS             complement(22071..23180)
                     /gene="ugpC"
                     /locus_tag="KNP36_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003242648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HBF0872698.1"
                     /translation="MSEVILKNISKLYSNGFNAVKNINIDIKDKEFIVLVGPSGCGKS
                     TTLRMIAGLEEISEGELYIGDKLVNNIEPKDRDIAMVFQNYALYPHLSVYENMAFALK
                     LRNLPKDEIDKKVKEAAKILDLLPLLNKKPKTLSGGQRQRVALGRAIVRNPKVFLMDE
                     PLSNLDAKLRTAMRTEITKLHQQLGTTFIYVTHDQVEAMTMADRIVVMKDGVVQQIAT
                     PQDVYDYPANIFVAGFIGAPQMNFIDVILIEENDEIYAQNEHIKLKLNKEKHYDLIKD
                     NYINNEVVIGIRPEDIHVEDTFIKSNPDTCFKSRIEIKELMGAETYAHLKLGENTITI
                     RFDSKNRINVGDDLTLSVDNSRVHIFDKETTLAIR"
     gene            23438..24175
                     /gene="cas6"
                     /locus_tag="KNP36_000810"
     CDS             23438..24175
                     /gene="cas6"
                     /locus_tag="KNP36_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endoribonuclease Cas6"
                     /protein_id="HBF0872699.1"
                     /translation="MSRISIFMESCNGKFPNENSMLSVSFIKNILNAENKDFAKNIFN
                     YGEERKNNKQIKDINTAIYIPNLIRSKNELLVDGDIIFNISFYNYSMFSKLYNGILKV
                     KELEYKGYRFKIKNIKIHKEHEIKENGVIFKTMSPIIVKNKEGKYLDVEDSNYIECLN
                     YIANLTLESIRGSGLRKPLEFIPINFKKRVLKEKIRGFKVREYYYINAYAGTFFLKGD
                     MEDLNALYKMGIGYRRTENAGMVDILK"
     gene            24180..25655
                     /locus_tag="KNP36_000811"
     CDS             24180..25655
                     /locus_tag="KNP36_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872700.1"
                     /translation="MREIKAKFYRSGDIVRDIGIVYFYELLMDLKNELEKNDYKLKFT
                     CELNRNYLSLESAEYIDPKYISDYILENRLFKVFKNGKKETLEKIFSNIDNLTYVNFI
                     EELDKSSATAKQKEDIKKDFKNRRFPYVRNSGKYGLNTSLENMETNVKRIVDTVIKSN
                     IEIDEIDKLDLTQYEEKDSVCNVCNINKTTKLDIDLRERKDSKYNFLFRGAEKSGFKR
                     SGQVESNICFECEFFNLMCLLYINLKRPMVFAYTNDLRELAFLNHKIMLKRKMYSDKS
                     FYKKLLHEKISSIRLYSFDIDTNKGIILKFDSIIEYKELLKKIELIDIIDNYNFSREP
                     GNTRNLGKRMIDNGNLSNLKELLLDNISVLKQSTGTSREMDFVSSSYNIGLYIKLCWI
                     VDGGEEYKMKNYMESNLIYSRVGKDLFNKMTDESRRKNFSMKVIQLLKSNDRTQLFQT
                     IMHVLVSNGILIGEGFVEGLMQSSELELNTNVGLFIQEIMK"
     gene            25675..26688
                     /locus_tag="KNP36_000812"
     CDS             25675..26688
                     /locus_tag="KNP36_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DevR family CRISPR-associated autoregulator"
                     /protein_id="HBF0872701.1"
                     /translation="MNEKRVKGVTLTILTESPVPLSYDQGYGNYTPIKKEQYREKIHA
                     KTSIATITYDLRRMLHQEYGWNLSNIVFGKKGNIYPSIKKNVGCVDENGLETDVFGYL
                     IPLKDKGSISKASPLRIIPFRSLNPYKGSTQLITNRGFLSSEFGRKYYDEKEENEVPR
                     DENFPTSQALAIEETLSDYYVYTITLELDRIGVVEVEDGKLLLPEERKFMSKELREKA
                     VKDILDAITVFTRNIKHSSVLLKPLAVIGGAFDKVVPFFWDDVDYNADSGEINLEGVI
                     ETIESYSLKESNTILAINDRLKISNKKELNKFNLSKYPVKEIKNLADRLEIGEDNMWY
                     LKE"
     gene            26704..27501
                     /gene="cas5"
                     /locus_tag="KNP36_000813"
     CDS             26704..27501
                     /gene="cas5"
                     /locus_tag="KNP36_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas5"
                     /protein_id="HBF0872702.1"
                     /translation="MKVLQCKLKQPTAHYRDPKVFQNEYISTLNLPSKTTIMGMITYL
                     CDRRLNSDIDIGIIGTHHHRELEFSRGENIDFWNEYIKMGKGKDKEKFLLKGNYYDYY
                     KEHKAQNSILNYEVLKEVELTIFISCKDDEELEFIRKKLESPCKYANLGRKEDFVIPS
                     EKGCFVKEVKLKEVIPMNTRDAIKENIKLKNTYVRVDLRDKENVETIINQGVLIALPH
                     KYKDLEANRDDRVYEFCHYIYVDNDGIYPKNIKVNVCIDTKEVFTWL"
     gene            27528..29936
                     /locus_tag="KNP36_000814"
     CDS             27528..29936
                     /locus_tag="KNP36_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated helicase/endonuclease Cas3"
                     /protein_id="HBF0872703.1"
                     /translation="MKNIMQKEILAKSYNLRTNQQEQTLVEHIKDLFEVLESILELNL
                     YSDKDVEILKICCALHDLGKINSIMQQKMEINNKISYSCSEEERKKLESDKKSLKKIA
                     RHNIFSGAFLKDILEKMNLSEEDKLYIYKSIMLHHGNYEDYMRLSISKVQEEIYEYIE
                     KGILEKEEFNLKDIESYINSILNVDFKFGEDVLDYDYIDKLSESMFIDSDYNNGQIDD
                     SVLNYRKFKYILYKGMLNLIDHSASSRQKGIKFYNDFTDEEIDNMILNEIYKSQGNLE
                     KNNIEFNTIQKRLRELSGRNVLTVAFTGSGKTAADYRKTFKRKFFLVPNKISAESFYR
                     KNIFQNKNDLDTRSSNDYIGLLHGDINLYSENEDNGEHDFVLTLRDIDLSINFCKPCV
                     IATVDQLLLSMFKFPGYEKIFAAVKNASITVDEVHLLEPKMFLILIYFMQFACKYLDV
                     DFHLMTATLPKSYKEQMINKGIIFQEESNENVTDKGEIVFIESNKEEEICEGKDVKVS
                     FIKEKEIKSIVEDALENKQKILIIKNTIDSVNRTYEFLKENLSDKYGGVDIDVLHSRF
                     KFKDKKEKYSKILNGEGDIWISTQSVEISLDLDFNIIISDLATMDSLIQRMGRCNRNN
                     KYEYGNFYILPSEDKIYDNKLKSTTKNILKDILKTNSIFTMGIRKTILDDYYDNSVVK
                     KYFEENFISCDKEIKNIYGVNKEIFDGLDLIFNFEPYKNIVDSKKEAAKIFRDVDVSY
                     KIILEEDFYKEDRELQQDSIQVSGFIFNRLYYYGLISKVEGYMVLKSSSKFEYNSTVG
                     LILK"
     gene            30377..31324
                     /gene="prmA"
                     /locus_tag="KNP36_000815"
     CDS             30377..31324
                     /gene="prmA"
                     /locus_tag="KNP36_000815"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HBF0872704.1"
                     /translation="MNNWIEVTIKTTTEAVEPITNILYEQGAGGAVIEDPKDFLFQKK
                     NELDWDYVEEEVFKKNEEDDVLIKTYVSEEKNVMEFVEIIKQKVLGLKDFGIDIGEGS
                     VSLDQVNEADWANAWKAYYKPTKVGQRVVVKPTWEDYAMQEGDLIIELDPGMAFGTGT
                     HETTSMCIRELEKYVNKDSKVFDIGCGSGILAIAAAKLGAKEVVAVDLDEVAVKVAKE
                     NVLENKVEKSVSVMHGNLTDVIKDKADVIVANIIADIIKILAKDVQNFMKEDAIFISS
                     GIILDKVEEVKESLIENGFEIVEVQKLGEWSAIVSKLKK"
     gene            31343..32101
                     /locus_tag="KNP36_000816"
     CDS             31343..32101
                     /locus_tag="KNP36_000816"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HBF0872705.1"
                     /translation="MDRFFVEKNNINLQDKTCTIEGEDVKHISKVLRCKLGEKLEICD
                     KNNNEYICEIMNIDKSIVNLEILEKVDINRESELKVRLYQGLPKAPKMEIILQKLTEV
                     GVEEIILVQTKRSVVKVDDKKEDKKFERWERIIYEAAKQSKRGKIPKLRGVLSFKEAL
                     EDMKKNSVNICPYENERTVSIKHALKKCDSNIDSVGIFIGPEGGFSEEEIEQIQKNNC
                     NVVSLGPRILRTETASVVASTIALYELSDLGGEK"
     gene            32103..33401
                     /gene="mtaB"
                     /locus_tag="KNP36_000817"
     CDS             32103..33401
                     /gene="mtaB"
                     /locus_tag="KNP36_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-
                     methylthiotransferase MtaB"
                     /protein_id="HBF0872706.1"
                     /translation="MKKVAFYTLGCKVNQYETEAMLELFEKDGYEQVNSEEYADVYVI
                     NTCTVTHMSDRKSRQYIRRVKKKNPDAIIAVVGCYSQVSPEEILDIEEVNLVMGTNDR
                     RKIVEEIKKINSSKKVSTVDDIMKVKAFEEIEISQTNGKTRAFMKIQDGCDRFCTYCI
                     IPYARGRVRSRDIDSIVDEVKKLANNGYKEVVLTGIHVASYGKDLKDRDIKLLDVIKQ
                     INQIEKIERIRLSSVEPILFTDEFVNEVLKMDKVCPHYHLSLQSGCDETLKRMNRRYT
                     TLEYKTIVDRLRSKMPDVAITTDVIVGFPGETNEEFKKTYEFLKEIELSQMHIFKYSP
                     RKGTPAATMENQVDPQMKHFRSEQLLNLSKVNFNKFATKFIGRELDVLFEQNIEGNKY
                     EGLTSNYIRVVVESDKNIQGQILKVKINDVKDEYVEGILL"
     gene            33444..33794
                     /locus_tag="KNP36_000818"
     CDS             33444..33794
                     /locus_tag="KNP36_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine triad nucleotide-binding protein"
                     /protein_id="HBF0872707.1"
                     /translation="MDCIFCKIANGEIPSTKVYEDDRVLAFNDLNPVAPYHILVVPKK
                     HYDSLIDIPDKEMDIVSHIHVVINKIAKEKGFDQTGFRVINNCGSDGGQEVKHLHYHI
                     LAGKKLPNYEAGQN"
     gene            33957..34136
                     /locus_tag="KNP36_000819"
     CDS             33957..34136
                     /locus_tag="KNP36_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HBF0872708.1"
                     /translation="MSEVRVRENETLDSALRRFKRQCAMSGIMSEVRKREHYDKPSVK
                     RKKKAEAARRKNAKK"
     gene            34166..34609
                     /locus_tag="KNP36_000820"
     CDS             34166..34609
                     /locus_tag="KNP36_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GatB/YqeY domain-containing protein"
                     /protein_id="HBF0872709.1"
                     /translation="MSLKQKLQEDLKSSMKNKDTVRKSVVTLIRASIKQYEVDNRVEL
                     DEDGIIDVIAKQLKQRRDALVEFEKAGREDLIKETEGEIEVLKEYLPQQLSEEELEEI
                     VKSTISEVGATSMKDMGKIMSVIQPKVKGRADGKLINKLVKQNLQ"
     gene            34720..35217
                     /locus_tag="KNP36_000821"
     CDS             34720..35217
                     /locus_tag="KNP36_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416623.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan-rich sensory protein"
                     /protein_id="HBF0872710.1"
                     /translation="MIISVKEIRNFLINIFIPLIIGYLSSILTMIISGTDISTYYLQL
                     TKPSFAPPAFIFPIVWTILYILMGISSYLILRKGYNLPKVRDAIFYYGLQLVLNFIWS
                     ILFFGFGLRFTALIDIIIMILVSIIMISKFSKIDKRSGYINLIYLMWLVYAGFLNYFI
                     WFINK"
     gene            35410..35973
                     /gene="raiA"
                     /locus_tag="KNP36_000822"
     CDS             35410..35973
                     /gene="raiA"
                     /locus_tag="KNP36_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HBF0872711.1"
                     /translation="MQIIVSGRQMKLTDGIKGYVDGKLSRLEKYLDPESEVKVTVSAK
                     KDRQKVEVTIIPINGQIIRAEDVEDDLYAAIDIVCDKLSRQVVKYKTKVKDKVQNNKS
                     IRFENLDFIDNSSEFDDYDYDDEEDENIVIERRKKFNVKPMSSEEAILQMELVGHNFY
                     MFRNQDNFEINIVYKRKAGGYGLIEQD"
     gene            36186..36422
                     /locus_tag="KNP36_000823"
     CDS             36186..36422
                     /locus_tag="KNP36_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YabP/YqfC family sporulation protein"
                     /protein_id="HBF0872712.1"
                     /translation="MLEISTDLQVNQPVITVTSNTFISIENYLSILEYEVDLIRIKTK
                     VKTIKISGDKLSLKYITDSEIGIKGIIYNVEYVD"
     gene            36435..37778
                     /gene="yqfD"
                     /locus_tag="KNP36_000824"
     CDS             36435..37778
                     /gene="yqfD"
                     /locus_tag="KNP36_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YqfD"
                     /protein_id="HBF0872713.1"
                     /translation="MISFIRGYYVIVVEGVGLEQFLNHLIRNGISVYNVTRIKNTKME
                     FHIDRQDIKDFKNVYRGSKFDIKVKQKTGVPFIIKRVYKHKGMWICALVSLFLLMSTS
                     QFVTDVYIQSPEGIKKEALRNELYKVGVRPGVYKKSIDRKEVRDHMMSKFNDVAYLSI
                     NVKGTNIFVTVTKKAESLKSTDQSNYCNVIALKNGIIEKVIPRSGKSVIKSGDIVQKG
                     DVLLNGANTKSIPEVWASTFYESTKKASYVDTVNKKTGEKKNIYTLSFYDKEFTMRKN
                     IKYKDYVVENKEKKLSIGNYTFPIKIKTSTFYETKKVEVKRNKEELKKELSEKALKEL
                     EYIIPASARIIDVKHNFKVNKNMLEYLITVQTSENIAKIYPLSKSEAERFIKEESKPD
                     EGEEEVPSNPEKRPLNDIRNEFDEDNKDNKDQNNSDENNSNQNSNNSQNNNSNNN"
     gene            37717..38832
                     /locus_tag="KNP36_000825"
     CDS             37717..38832
                     /locus_tag="KNP36_000825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HBF0872714.1"
                     /translation="MKIIVIKIVIIVKIIIAITTNKIKLKILGGLIQLIIQKKFTIAD
                     GNFERELFGNFDENVKLIEKTLNIDVILREGNIILIGEEKNVDSALKLMNELHQTVSN
                     GKHLDKQSISYSLSLLLEGSEQKIKELEGTIVITQRGKAVQPKTLGQKEYIKLIENND
                     ITFGVGPAGTGKTYLAVAMAVKAFKRDEVSRIILTRPAVEAGESLGFLPGDLKDKVDP
                     YLRPLYDALFEMLGADKFNKYLERGTIEVAPLAFMRGRTLDNSFIILDEAQNTTSEQM
                     KMFLTRLGFGSKAVVTGDVTQTDLPQNKKSGLIQATEILKGVPGIGSIMLTDRDVVRH
                     ELVQRIIRAYEKHDKREEFKKEERKKAKMQEKTFKRK"
     gene            38889..39350
                     /gene="ybeY"
                     /locus_tag="KNP36_000826"
     CDS             38889..39350
                     /gene="ybeY"
                     /locus_tag="KNP36_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HBF0872715.1"
                     /translation="MDLILDDRQDKLEVSEELIEKIKDIIIECLDYEGYDDNYEVSLS
                     FVDNKEIHELNREYRGVDRVTDVLSFPLLSDDFEDVELEEESLGDIVVSLERALEQSI
                     EYNHSFEREVCFLICHSMFHLLGYDHDTDENTKEMREKEEHILNKLNITRE"
     gene            39356..40075
                     /locus_tag="KNP36_000827"
     CDS             39356..40075
                     /locus_tag="KNP36_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HBF0872716.1"
                     /translation="MKPEKTRQGIIKAFNAAIEGILYTFKFERNMKIHYLGSVAVLII
                     SLFFNFSKLEMIMLLMSICLVVVAEMFNTAIEKAVDLVTDEYHVLAKIAKDVAAGGVL
                     VAALNSVVVGYILFYDKLTDISGILIYKIRESELHITLICILLVLIAVVVVKALTSTG
                     TPLKGGMPSGHAALAFAIATAITLMTERVVASTLAYIMAVLVAQSRIEGKIHTFWETI
                     AGALLGVLIAILVFQLGMFYN"
     gene            40194..40595
                     /locus_tag="KNP36_000828"
     CDS             40194..40595
                     /locus_tag="KNP36_000828"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HBF0872717.1"
                     /translation="MDNIELLRLAEDARQHSYAPYSGFRVGAALLTKSGKVYTGCNIE
                     CASLGGTNCAERTAIFKAISEGDKDIYKIAIASDNSENNEQTYPCGICRQVIIEFGSD
                     IKIITGYTKGEVFEHSIKDLLPNYFSGNDLK"
     gene            40659..41552
                     /gene="era"
                     /locus_tag="KNP36_000829"
     CDS             40659..41552
                     /gene="era"
                     /locus_tag="KNP36_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HBF0872718.1"
                     /translation="MFKSGFVSIVGRPNVGKSTLMNNVVGEKIAIMSDKPQTTRNTIQ
                     AVYTDEEMQIVFLDTPGIHKPKNKLGEFMVKAATEAFKNVDLILFVVDDSKKIGPGDR
                     KIIEDLRSVKTPIILVVNKIDQLDQKDELFDIIKMYDREGIFKEIVPISALKGKNTDT
                     LIKVIQNYLEEGPKYFPDYMITDQPERVLIAELIREKVLHYLNDEIPHGVAVEIEKMK
                     ARNDKEIVDVSAVIYCERDSHKGIIIGKNGRKLKGIGKSARQDIELLLGSQINLQLWV
                     KVKENWRNLQNYINNFGYNDK"
     gene            41564..42943
                     /gene="mgtE"
                     /locus_tag="KNP36_000830"
     CDS             41564..42943
                     /gene="mgtE"
                     /locus_tag="KNP36_000830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter"
                     /protein_id="HBF0872719.1"
                     /translation="MDRKLDASQDLLYEVKSLIDNNKVLELRELIEEYHIIDIFDIME
                     NLEEDMKIQLFEVLPLDMASSILEEGSVEFFISILSKLDVEHSKNILELMSLGDMADK
                     LSELEEEEREHIINLLNQENADYVKELLFYDEDSAGGTMTTGYISINKDMTALEAIDH
                     MREEAEEAETIYYIYVVDDEEKLVGVLSLRELIIARDANIVEDLMSENIISVYVDEDR
                     EEAVRLVSKYNLIAIPVVDRQEKLKGIITVDDIIDVMEEEATEDMYKFAGSSEHEREV
                     AEKENPTLREQIISALRGRLPWLIITLVGGLLASLILSNLDYIMNPVYAPLVFFIPVV
                     IGMGGNIGTQSSSVTVITLSNKDLNFSNVVREGIVGIITGLLCSIITGIVIYFVMRKL
                     DIVLIVSISLFINMVLGATIGAFMPVLLKKMDADPSTVSSPIISTALDITGIAVYFII
                     TTALLSKIV"
     gene            43016..43171
                     /locus_tag="KNP36_000831"
     CDS             43016..43171
                     /locus_tag="KNP36_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqzL family protein"
                     /protein_id="HBF0872720.1"
                     /translation="MNNISWEVFKKTGSIDAYLYFCDCKNIHEEIEEVREKKEDDDNP
                     EHPGDST"
     gene            43137..43910
                     /gene="recO"
                     /locus_tag="KNP36_000832"
     CDS             43137..43910
                     /gene="recO"
                     /locus_tag="KNP36_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HBF0872721.1"
                     /translation="MIILNTQGIVLKAIRYKESDIILTLFTRKLGKVSAIAKGAKKNK
                     SSLLSSSQLFSYSNFTLKKQGNMYKVTQSEIIKSFYNISYDIEAFSYATYITKLVENS
                     ILENQTNNRLFILLAQTLYLYTQDNTDNRFITAAFELKFLDYIGFKPIVNKCINCECK
                     ILQNSVFNIYEGGILCSKCSKLFDNNIKLDLTTISLMEYVLRNDILTCSKAKVSKYIT
                     HELENILDKYLKVYVDNINFKSLHVLQSVKNNKGVDNDE"
     gene            43903..44502
                     /locus_tag="KNP36_000833"
     CDS             43903..44502
                     /locus_tag="KNP36_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4342 domain-containing protein"
                     /protein_id="HBF0872722.1"
                     /translation="MSSNITIEMVDSVFERVPGATYAEAKEALVMCNGDVIEAVIYLE
                     NKKNTCNCKAKSAKETMEEVFGKDGENIKFQLKELLRKSSVVRIIVEKDGKTMMNIPL
                     TVGVVGLAFVPLATLVGLSAAVISKYRIKVQNEEDGEIVDLGELNEEKLHVLKNMITN
                     AAKDVKDVVVDKKEDDKDVTADLMKEESEKNKEDEDENK"
     gene            44662..45540
                     /gene="glyQ"
                     /locus_tag="KNP36_000834"
     CDS             44662..45540
                     /gene="glyQ"
                     /locus_tag="KNP36_000834"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HBF0872723.1"
                     /translation="MNFQEMILALQKYWSKQGCIMMQPYDIEKGAGTMNPNTFLRSLG
                     PEPWQVCYVEPSRRPADGRYGENPNRLYQHHQFQVILKPSPDNIQELYLESLKEIGID
                     PSEHDIRFVEDNWEAATVGAWGLGWEVWLDGMEITQFTYFQQVGNIECELETGEITYG
                     LERLAMYIQEVDSVYDLKWNDKITYGEVFNKAEYENSMYAFELCDADMLFNLFDIYEK
                     EALRLMENGLVIPSYDYVLKCSHAFNTLDARGAIGVSQRASFIGRVRNMAKTVAETFV
                     KQREEMGFPLLKDGDK"
     gene            45540..47606
                     /locus_tag="KNP36_000835"
     CDS             45540..47606
                     /locus_tag="KNP36_000835"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HBF0872724.1"
                     /translation="MKNYLLFEIGVEEMPSRFVGSTLEQLKNNLSKLFDENRIAFDKI
                     NAYGTPRRLTLVVEGLSDRQNDLEEEIKGPAKKIAVDAENNLTKPALGFIKSKGLSES
                     DIYFKQVGKEEYIFATIKQDGKETSEVLKDILPETIKSVVFPKAMRWGGKNLKFARPI
                     RWIVALLNDKVLEFDLEGIISSNVTKGHRFLGESTIEVDSIEDYFEKLEKNYIVLDQN
                     KRKEMIRKQCIEVANSLGGEVEFDEDLLEEVTYLVEYPTAFYGEFDVDYIKLPKEVVI
                     TPMKQHQRYFPVLKEGKLLPNFIAVRNGDSYRIDNVKAGNEKVLEARLADALFFYRED
                     TKRNLESYIEKLKTVVFQVKLGTIYDKTLRLEKLSADILDSLGLVDEKADTIRAAKLS
                     KADLVTGMVGEFDELQGFMGKEYAKVGGENDVVSEAIFEHYLPRFAGDILPKTNAGVA
                     LSIADKLDSIAGFFAIGIQPTGSQDPYALRRQALGILSILMDRKVAVDIKVLIEHALD
                     NYSELDFNKEEVVEQIMNFFNERVKNLFKDLGIRYDVVDAVLSSDINDVSDMHMRALE
                     LNNWLEKDELVEMLTAFNRVSTLAQKAESDKIDESLLKEDAEIKLYNEFKQVKVKVNE
                     LLKDKKYGIALDEFASLRPVVDNLFDTVMVMDNDEAIKNNRLALLKQVYDTMLGICDL
                     SKIVYK"
     gene            complement(47772..49319)
                     /locus_tag="KNP36_000836"
     CDS             complement(47772..49319)
                     /locus_tag="KNP36_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitrite/sulfite reductase"
                     /protein_id="HBF0872725.1"
                     /translation="MDNFKKILLNELPNFKEYSSKFLNGEINKMQYKGFSGGYGVYAQ
                     RDKKSFMIRLRVSAGVLSQYQLNKIYEIAIKHNLDKIHLTTRQAIQLHDLSINSIVDI
                     MEEGIKNDIFTRGGGGNYPRNVGLSPLSGVDPSEVFDVTPYAVATDKYFIKNATTYHL
                     PRKLKVSYSNCYTDTAHCSIQDLGFVATLKNDEPYFRVFLGGGLGKQPKVALELDELI
                     KPKDALYCVEGMIKFFMDYGNYENKNRARVRYMVESLGEKLFLEKFKEYYKLEKENGS
                     LELNIEEIDYSKPGVKIDIQDSRLIPQKQDGLYTVYIHPVGGILLTKDLSTLLKELDN
                     IENPMIRLGMTEGLYILNLNGNEAKRILEISKTISCNSQLEQSISCIGVPICQMGIQN
                     SQKMLHEIIDYFRLQNNKEILNKAPKLYISGCLNSCGVHQVGSIGLCGKKKNVDGIST
                     DAFELFVGGSFEIGKTRLGKSLGDFKASDIPEMLYKISDASSGNFYEWVNSNDNILNK
                     ITDKYKI"
     gene            49599..50366
                     /locus_tag="KNP36_000837"
     CDS             49599..50366
                     /locus_tag="KNP36_000837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IclR family transcriptional regulator"
                     /protein_id="HBF0872726.1"
                     /translation="MGEIINALDRALDIILLLYHEKREMGITEISKAMGVYKSTVHRT
                     LVTLENKGFVIQNAENGKYWLGINLYAIGMVVGEKMSLTEIVKPYTKKLNQEFNEVVN
                     VSILEERAQDSPRSIIIHKEYGSNQLLSVNPSVGSSSECYCSAVGKCLMAFNDSIDFE
                     KYRKTPIHKYTEHTIDNWDDMMLFLAKIKEQGYAIDDEELEHGLTCIGAPILDKNNKA
                     IAAISLSGPTIRMREGDFEYKIKRVIETAKSISELFR"
     gene            50649..50846
                     /locus_tag="KNP36_000838"
     CDS             50649..50846
                     /locus_tag="KNP36_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0872727.1"
                     /translation="MEKVKLSVERCKGCYLCIEACKKDAISLSDYTNKKGFVTIKVDE
                     EKCIQCGACYTMCPDLVFEIL"
     gene            50875..51951
                     /gene="vorB"
                     /locus_tag="KNP36_000839"
     CDS             50875..51951
                     /gene="vorB"
                     /locus_tag="KNP36_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBF0872728.1"
                     /translation="MQSLLIKGNEALAEGAIRGGCRFYAGYPITPQSEILEMMAWRQK
                     EVGGVFIQGESEIASVNMVMGASALGARAMTSSSGPGFSLKQEGIAYWVSAGLPAVVA
                     CVQRYGIGDGFIGAGQDNYWQAVKGGGNGDYHLIVLAPNSVQENMDMAYESFELAEKY
                     MHPVLILSDATIGQMVEPCIAPPMKEYDMDKAPWAAKGTPVGEKNKVITDITYFEDQD
                     TWQKGYIEKMRKVQEDEQRWEEIEIEDAEVVFVAYGISSRIAEGAVRDARAKGMKLGL
                     IRPKTLWPYPRKAFKKLSDSLKGLVTVEMNMMAQMKEDVIIACDNRFPVYSVATAQYM
                     AEVNQLIDFAQQIIDGKAKQEEVF"
     gene            51954..52673
                     /locus_tag="KNP36_000840"
     CDS             51954..52673
                     /locus_tag="KNP36_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBF0872729.1"
                     /translation="MAKKAPAIMMCENMFCGGCGHSIVDRIIGEVLTEMDICQDTIIC
                     SDIGCNHMFQFSMNVDVVVPPHGKMGAAMAAMKRVRPDKYIFTIAGDGGAYAIGLGET
                     MSAATRNDNVIFLVMNNNMFAMTGGQMAPTTIEGQYTASTPAGRNYADHGSTFDVVKV
                     MGNLDIAYLARGTITNPKEINTTKRYIKKALEKQKEKKGFCLIEVLVPCPTNWGLKPV
                     DAMKRIENELVPKYPLGEFID"
     gene            52686..53225
                     /locus_tag="KNP36_000841"
     CDS             52686..53225
                     /locus_tag="KNP36_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBF0872730.1"
                     /translation="MLNEIICAGFGGQGVLTAGKIIMYVAYKAEKKITWFPSYGNEMR
                     GGSANCNVVVSDEKIANPCVKNPDILLGMNSVSVDKYESLMKKNGYMFVNESLVSKDR
                     KYREDINVIKVPVTEIAQNLGNEKAANICMLGAMVKSLDLFTKEEFESGMCEYFENQG
                     KGKFNSKNVEAFEAGYDYE"
     gene            53382..54440
                     /gene="buk"
                     /locus_tag="KNP36_000842"
     CDS             53382..54440
                     /gene="buk"
                     /locus_tag="KNP36_000842"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBF0872731.1"
                     /translation="MKVLVINPGGTSTKISVFQDENEILKKNITHTREDLKNFSKVFD
                     EYDYRKQLIVDILSSENHSINSFDAVVGRGGLMKAIKGGTYTVSEEMIEDMRNEINGE
                     HASNLGALLAKTIADEIGVQSFVVDPVSVDEFDDVSRITGISDIEKASWLHALNHKAV
                     SRKIAQKLGGKYEDYNFIVAHLGSGISIVAHKQGKMIDGSGGRSDGPFSPERSGGLLA
                     YPLIELCYSGKYTHDEMVAKVSSIGGMYDYLGTKDMIEIENRIKEGDEKAKLIMDAFI
                     YQVAKEISMYGASLSGNVDRVILTGGISHSEMVVKGVAEKVSYLAPIEIVPGEMEMEA
                     LALGALRVLNGEEIAKTY"
     gene            54458..55351
                     /locus_tag="KNP36_000843"
     CDS             54458..55351
                     /locus_tag="KNP36_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional enoyl-CoA hydratase/phosphate
                     acetyltransferase"
                     /protein_id="HBF0872732.1"
                     /translation="MLKDFNNLLEEAKKLEPVIVSVAVAEDKEVLKAVKSATDLNIIK
                     PILVGDKDKIESISREIGLKGHEIIGCQNPDESVKKAVEIVKNKEAKVLMKGLVNTSV
                     YMRAILNKETGLRTGRLLSLLAVYELPQYHKLLYCTDSGINVSPNLNQKKDIMTNALL
                     TMKSIGMENPKTAILTANEMVDPKIQSTVDANLLVEMEKSGEIPKCIVEGPIAFDVAF
                     DAHAAEHKGIKSNIAGDVDLLVFPNIEAGNILGKSWLRFNKAKWAGIVLGATNPIILG
                     SRSDTAEIKINSIALACLASQ"
     gene            55381..56589
                     /locus_tag="KNP36_000844"
     CDS             55381..56589
                     /locus_tag="KNP36_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0872733.1"
                     /translation="MKYAKRMDMVKASAIRDSQKKIAQKVASGGTVISFAAGLPDPNL
                     FPIEEISEITQKVLNERGKFALAYGPTKGEDELLDLLVKRMKEEENIDTKAENIIITT
                     GSQQGIALSAMILLEKGDVVVTENPSYLGAINAFRPYECDFLGVDTDEEGMVTDDLDK
                     LLSENSNIKVIYVIPTFQNPTGKTWSLQRRKDFMEVVNKYDVIVIEDNPYGEIRFTPE
                     PLPTLKSLDTKDKVLYLGSFSKVLCPGFRVAWMCGNVDIIDKAELLKQGIDLQSNQFS
                     QVQVIEFLKKYNLNEHIEKIRAEYKKRCLLMLDAMKKHFPEEAKYTEPDGGMFIWVEL
                     PESINVDDLLDKAIDAGVAYVSGESFFANNGPKNTMRLNYTTMSEEQIVKGVEILAEV
                     IKKELNYACE"
     gene            56613..57872
                     /locus_tag="KNP36_000845"
     CDS             56613..57872
                     /locus_tag="KNP36_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0872734.1"
                     /translation="MGEKENGIKFGKLMFQLVIIAISWELVYIIPFIQYTLYDPILKA
                     LECTNTQLGFLLTIYGLGNIFGAPIGGWLADRFDYRKIILGSVFLNGVVSFLFAFNMN
                     YPFAVATWVGCAITSLVMNYPSMVKILRVIGKDNQGKVYGFNEAMVGVSGVVMGAIFL
                     YIYTCFATPTLGMRWVMISLGILSIAMCPVLWFVIKDVDIKEEREEAGEKMSAGDFIT
                     VLKSPNTWLVGISIFCVYSFTVTMSYFTPYITSVLGGSVALSGALAIIRQHGLKLFGA
                     PFGGYCADKLKSPTKVLLPIYVFGIAVIVLFLVLPASTPMTIFIALTFVVGILGYMGK
                     GIYYAVQDEVKVPVKYSATTIGIAAALGFSPDVFQFALIGHWIDTYGNKGYTYTFIFQ
                     IAILVIGILSCLYILKVKKRRASKLEA"
BASE COUNT        23218 a         6126 c        10488 g        18380 t
ORIGIN      
        1 gtatttaaag taagtgtagt aatagctaaa attatatctt tttttaatag tacatttata
       61 gaaagcatat tttttttact agaaaaaatc agcaatttaa gttttgcata cattaatata
      121 gaaaatccta aattttatat tgttgttatt tattacatag gagtgttttt ttacatattt
      181 tacatagaag gaaaagagat aaaggagcaa gagaatgaat tacaaggata ttataaggaa
      241 tgtaaaagag aaaaactttg aaaaaatgta tcttttttat ggaagagagt attatttaat
      301 tgagaatgca ataaaagcat ttaaagatag tctaaacgag ggaatgcttg attttaactt
      361 agatataata gatgggaagg aaatagtctt aaatcagctt ataagctcta tagaaacact
      421 tccatttatg gatgatagaa agatagtaat aataaaagac tttgaactat taaaaggaaa
      481 gaaaaagaat tttacagata gtgatgagaa atacttaata gagcatttag acaatattcc
      541 agacaccaca actatagttt ttgttgtata tggagatgta gacaaaagaa aatcattagt
      601 taagaaaata ggaaacaatg gaattgtttt tgattgtgat aagctttctg atatggattt
      661 gtttaaatgg ataaaaaaat cttttgcttt aaatgatgtt ataatagata attctcaaat
      721 catgtatttt attgaacaag aaggatacag agataagagt agtgaaaaga cattatctga
      781 tttagaaaat gaaataaata aaataagttc atttgttggt aaagggaata atgtaaccaa
      841 tgatgtaatt gataaattat ctcaaaaaaa agttgagaat gatatattca aattaatcga
      901 ttatattgga gaacaaaatg cttctaatgc aatgaaaata ttaaatgata tgatacaaga
      961 aggcgaatct gtattaggta tattttctat gatagcaaga caatttaaaa taattatgca
     1021 agtaagacag ttacaacttg atggatattc aacaaaactt atagctgata aattaaaaat
     1081 gcatcaattt gttgtaggaa aagcattaaa gcaaactaaa aatttttctg atgatataat
     1141 tgtggaaata ttaaactata tattagaaag tgattataaa ataaagacag gtcttataag
     1201 agatacttta gcagttgaaa tgttggttag tagatactgt aaaagagaag caatttaaaa
     1261 aatctatata ttaataaaaa ataaatagca agatatgtta tagttcagag tagatgtaag
     1321 ctaaattaag tttgatatac aatcaactat aatatgtcta actatttatt ttttattgta
     1381 taaatttaca aaataaaaaa cccctacata ggggttatta tatataagaa atataaactg
     1441 gtaattaagc gttcataccg tttaattttt gagctaattt agctactttt ctagctgcag
     1501 cattcttatg tatagttcct ttagaagcta cttggtatat tcttttttga gcgtattgga
     1561 acttagcaac agcatcctct ctgtttccag ctgcaacagc atcttcgaat cttcttattg
     1621 cagtttttat ttgagatttt ctaactctat ttaaagcagt tttcttttcg ataacactta
     1681 ttcttttctt agctgatttt atatttgcca ccgtgttcac ctccctgtat ttttttatca
     1741 tattcatcgt caacatatta gattttaaca gaaataaatc taaaaatcaa ggattattat
     1801 ttatatattt taataatgtt ttttattttg attttttaga ctgtaaattg tgtataaata
     1861 atttgcaata tcttgttttt aaattggtat attttgtgtt ttaaatattt tgacatatat
     1921 aaattaatat tttatttttg taacaaatat tttgagataa tacaaactat taacatacat
     1981 tttgatagta tttccaataa ttataagata atacaagaaa ttactcattt ttgtaaattt
     2041 aatgaaaaat tataaaaata taaatttata tgcttaatta agataatttt tttcattagt
     2101 atgtatgata gatgcatcaa acaatataac taatatgtta gaaggttata tgtaattaat
     2161 gtcagtgttt atatagaata gcatttgtag catttattat agttgtaatt actatttata
     2221 tcatagactt gaatagtcta aaaaaataga ctataatatt tttatagact aaagaaaggg
     2281 ctgataagat ggacatagca aaactaattt taaatcctgc aaggcttcgt attttacaat
     2341 atattcgact ttatggcagt gttcgtacat ctgatattgt aaagtattta aatgatattc
     2401 ctcgtgcaac agtttatcac catgtaaaaa ttttagaaga gaacaatatg attgaagtaa
     2461 ttaaagaaaa tcgtgtgcgt ggtactattg aaaaggttta tgcactaaag gaatatacaa
     2521 catctatgga aggagagacc ttcgttgcac tttctacagc attttatgta ggtctgatgc
     2581 aggaaatgaa tgaatacttt agcagaaaag agcaagacca taaaaaggat aatgtatttt
     2641 tctcttcagc attactatat atgagtgata atgaatatga aaatcttctt aaaagtatag
     2701 ctgatttatt gaaaccatat atagaacaaa aacctaaatc aaatctaaaa cttagaaaac
     2761 tttcaattat atcttctcca cctgtagctg ataatgataa aacaaaataa catgcaaccc
     2821 atttttataa aaggaggtta tatatgaaat ttcatgagtt tggaaataaa aacagaccac
     2881 atattatgtt gattcatggg ggagggaatg catggtggaa ctatttgcga caagcagaag
     2941 ttttgtctaa caaatatcat gtgatacttc ctacattgga tggtcatgga gaagaatatg
     3001 aaacaacata catttctaca gaggatacag cagataagtt gatatcatat atagatgaaa
     3061 attgcagtgg acatcttttc gctttgtgtg gggtatcact tggtggtcaa attgtcatgg
     3121 aacttttatc tcgaaaacct aatattacta aaaaagcaat tattgatggt agtatttgct
     3181 acccaagacc tcttatggca aggttttgta ttgctggtat tcgatttttt ggaggacttt
     3241 tgtttagtga gaaggcttgt cgctttcaaa ttgctatgat gccaaaattg ttacctgaaa
     3301 atatgcaata tccagataaa ataaaagcgt attatatgac agatatgcca catgtaagaa
     3361 aagaaacatt ctataatatg tatcgtactt acatgatgaa ctatacactt aaagagaatg
     3421 ttaaaaaaac cacagcacaa gtaatgtact ggtatggaga aaaagaaatg aagtgtgtca
     3481 aaaaatctgc aaaactgttt cagtcttatg tgccctcttg tgagatttat gaagctaaga
     3541 gctataatca tgggtattta tcactttatc ttccaaatga atggttggaa attgcagaac
     3601 catttttcca aaaggaataa aggtgttagg tgattattgt ataattattg ctgttttttt
     3661 atatagtaaa taaattaggt ataaatataa aaaattattt tagttaatat attagtgaaa
     3721 gcttaatagg aaaattataa atagattaaa ggtagcacct atataaatag ttgctacctt
     3781 tttctgtttg taaataaatg atagataaga aggtttactg acaaatcact gactaaaccc
     3841 aattttctta cattgaaagc cttaatttta cttgttttaa ataaatttac aatttcttgt
     3901 tataaaatac taaattttgt taacaattat aattagcatt taatttatac tggaggttta
     3961 tatgattagt gtaagaacag atttagcttt agaagctagt gaaatgtgtg aaaagtctca
     4021 agaaggaagt agtattcctg gtgtaaaaat agaaactaaa gaattagaaa attgcattgt
     4081 aactaaagtt gaagtaatag acaggcaagg cgcagagata atgaataaag atataggaaa
     4141 gtatataact ctggaaagta atcttatgaa gtttgatgat gatgagtcaa gagaagaaat
     4201 gataagttat ttaaaagagg agttagtaga tatatttggc caagacaaaa ataaaaaaac
     4261 cctggtaatt ggtcttggaa atagaaatat tacttctgat gcgttaggac caaagagtgt
     4321 atcaaaaaca cttgtaacta gacatctttt taaaaattat aataaagact atgatgatga
     4381 tttcactgag gtatcagctt taagcccagg agttatgggt gttactggaa tagaaactag
     4441 tgaaatagta aaatcattgg ttgagaaggt taagccagat agagtagtag caatagatgc
     4501 attggcttca agaaaaatgg aaagagtaaa ctctactata cagatatcaa cagcaggaat
     4561 atcacctggt ggaggtgttg gcaatactag aaaatctcta actaaagaaa ctttaggcgt
     4621 ggatgttatt gcaataggcg ttccaacggt ggttgatgca gcaactctta caatagatgt
     4681 cttagatatg gcaatagaca atttaatagc tcaatcagaa gaaacagaaa gtttttatga
     4741 aatgttgaaa aaacttaaag aagaagaaaa atatcatcta ataaaagatt cgttagaccc
     4801 atatgacaag aacttaatag taacaccaaa ggatatagat gatacaatcg aaaatctatc
     4861 tataataata agtgaaggct taaataggtc tttacatcca ggtagattgg tataaaataa
     4921 ggaggagcaa ttatgtttaa aaaatgcatt aaagtagtaa ccttgacttt tatattagta
     4981 tgcattttac caggaaaatc attagctttg aatcaagatg attttttaaa gtttttagta
     5041 aattcatctt atccagaagc taaagtcgaa ggaaatgata cagaaaataa aaagaataat
     5101 aaaaataaag aaacaagtaa ggaaaataag gaagaaagta aagaaggaaa cactaaatct
     5161 aaagatgcaa gtaaagttga taataaaaaa gagagtgaaa aagaatatat aaaactttat
     5221 gttggtaaag aaaatgttcc agatattgag tcaaaaaatt cagacacaac tgaaactaac
     5281 acaacatcta gttcagatta taaggatgat ttaagagtaa ccaaagaaaa tccaagaatt
     5341 ttgatatatc atactcatgg atgtgagact tattcaaatt cacctgatgg aaattatcat
     5401 tcaagagata agaaaaattc agtaatggaa gtaggaagtg cattaactag tgctttagat
     5461 agcaaaggat ggggtgtagt ccatactact aaataccatg actatccatc ttataataac
     5521 tcttatgcaa gtagcttaaa aacaatacaa agtatattac ctaaatataa ctcagtggat
     5581 atagcgatag acttacatag agatgctagg gatttaacta atccagccac taaggaaaaa
     5641 gaccatttaa aatatacaac tatgataaat ggagagagag tatcaaagtt cttctttgtt
     5701 gtaggaggta aaaatacaaa tagaaaacaa cttagagctt tagcagaaga tataactgct
     5761 tttgctgaga aaaagtatcc tggtctagta tctccaatag tagaaaaaga ctatgctaga
     5821 ttcaatcagt ttgcagttaa gaatcatatg ttagtagaaa tagggaataa cgcaacaagt
     5881 gtagaagaat ctaaggctac tacaaagtat ttagccgaga ttttggatga atattttaaa
     5941 caaaaaaatt agagctttaa gttataatta ggagcacgct aaatgagccg attagaaaaa
     6001 aatatagaaa gtaaaagtaa actaagaaaa tacaagtata ttatgagaat cttatttttg
     6061 attactatga ttatatgtac atcagtttgt gtatttatag tggacagtaa tgcaaaaagt
     6121 atgctaggaa tgaaacaata tgattttcca agtattaaat ttgatataac aaaatttgat
     6181 tttgacatac caaattttga tatacatgaa atcataaaaa aatttaataa gtagtaataa
     6241 gtgaataagg tttattgatt aaaataagcc ttattttagt tatatatttt taatgtataa
     6301 aataaaaatt cattaactgt attttatagg atttacttta agtttatgat attatataat
     6361 atttagtgtt agacttgata atccacatat aatgtggata attttgttta gtgccaatta
     6421 gtttatattc aaaaatttta aatttggtat ataaagagtt tttagataat gtaaaataat
     6481 aactataaga ataatcaaga ggagggaatt ttaaggtgga caataaacaa agtagaacta
     6541 gaaattttag tataattgca catatagacc atggaaagtc taccttagct gatagattaa
     6601 tacaacaaac tgggcttgtt agtgaaagag acatgaaaag tcaattactt gacaatatgg
     6661 accttgaaag agaaagagga atcactataa agcttcaaaa cataagatta atgtataaag
     6721 cgaaggatgg aaatgaatat tatttaaatc ttatagatac acctggacat gtagacttta
     6781 actatgaggt atcaagaagt ttagctgcat gtgaaggagc actattagta gttgatgcag
     6841 ctcaaggtgt tgaggcacaa actttagcca atgtttatct tgctatagac caagatttag
     6901 aaatattacc aataataaat aaaatagatt taccaagtgc aagaccagag gaagtaaaaa
     6961 atgaaataga agatttaata gggcttgatt caagtgaagc tcctcttatt tcagctaaaa
     7021 ctggtttaaa catagaagat gttttagaag atattgtaaa aaatgttcct ccacctaaag
     7081 gagataatga agctccatta aaggcattaa tattcgattc ttactatgat gcttacaaag
     7141 gtgttgtagc ttatgttaga gtatttgaag gaactgttaa aaagggtatg acaataaaaa
     7201 tgatgaatac caataaaaag tttgaggtaa ctgaagttgg tgttatggct ccaggtcaaa
     7261 ctgaacttag tgaattatca gcaggtgatg ttggttatat tgctgctagt ataaaagata
     7321 taagaagttg tcgtgttggt gatacaataa cagattcaaa taatcctaca gaagaacctt
     7381 taccaggata caaaaaagct actccaatgg tatattgtgg tatatatcca ggagaaggag
     7441 aaaagtatga gaatgttaga gatgctcttg aaaagcttca agtaaatgat gctgcacttg
     7501 aatatgaagc tgagacttca gcagcactag gatttggttt tagatgtggt ttcttaggtc
     7561 ttttacatat ggagataatg caagaaagac ttgagagaga atttaacctt gatataatta
     7621 ctacagctcc atctgttata tatagagtta caaaaatgga tggagaggtt gtaatgatac
     7681 aaaatcctgc aaacttacca gaaccatctg agataaagat gatagaagag cctatagtaa
     7741 aaggagatat aatagttcct aaagactatg tgggtgttgt tatggagctt tgccaggaaa
     7801 gacgtggaaa tatgttaaat atggaatata tagatgatag aagagtaatg cttcactatg
     7861 accttcctct caatgaagtt gtttacgatt tctttgatgc tttaaaatca agaactagag
     7921 gttatggttc tcttgattat gaggttaaag gttatgtagc atctacactt gtaaaacttg
     7981 atatattaat caataaagag caagtggatg cacttagttt tattgtccat gagacacgtg
     8041 ctttccctag aggaaaggca atgtgtgaga aattaaaagg agaaattcca agacatcagt
     8101 ttgctatacc aatacaagct gctgttggta ataaggttat tgcaagagaa acaataagcg
     8161 ctctaagaaa agatgttctt gctaaatgtt atggtggaga tatatctcgt aagaagaaac
     8221 ttcttgaaaa acaaaaagaa ggtaagaagc gtatgagaca aattggttct gttgaagttc
     8281 ctcaaaaagc atttatgtct gtgcttaaat tagatgagta aatccttata aatttagata
     8341 aagatattta aaagctagag tgattttaga attatttcta aattagtcta gcttttttat
     8401 ggtatatttt aagtaaactc atagagaata taagtaagaa tattaaagaa gaataaaaag
     8461 gtgatattta tgattaatat agaaattcct aaaaaagtag actatataat taaagaatta
     8521 gaaaagaatg gttatgaagc ttatatagtt ggaggatgtg ttagagattg tttattagaa
     8581 agagttccaa acgattggga tataacaact agtgctagac cagaagtggt agtagaatta
     8641 tttgaaaaaa caattccaac tggtatacaa catgggactg taacagttat gattgaacat
     8701 gaaccatttg aagtgacgac ttatagaatt gatggaaatt atagtgatgg tagacatcca
     8761 gattcaatag aatttacaaa taacatagtt aaggacttgt caagaagaga ttttactatc
     8821 aattcaattg catacaattc aaagacagga ttagtcgacc catttaatgg ctatgaagat
     8881 atacaaaata agtatatacg ttgtgttgga aatccagtag atagatttga agaagatgca
     8941 cttagaatgc ttagagcagt tagattttca gcacaactca attttaaaat agctgaaggt
     9001 actaagcaaa gtattcataa aaaagcagat ttgataaaaa atgtttctat tgaaagaatc
     9061 cagacagagt ttaataaaat attagtatct gattcatcta aattaaactt attaaaatca
     9121 acaggtttgt tgaaatttat aattcctgaa atatgtgaat tagaagatgt tactcaacac
     9181 aatccatatc acatctatga tgtacaaaaa catactttaa tagctacaga agtaattgaa
     9241 gatgaactgt atttaaaact tacaatgttg tttcatgatt taggtaaaaa agtaactaaa
     9301 acaactgata aaaatggtgt tgaccatttt tatactcata gtagagaatc tgtaaagatt
     9361 gcaaagaaga ttttgaaaag acttaagtat gataattata ctattaataa agttttaata
     9421 ttaatacaat atcatgatta tagaatagaa cctaaaagga agataattaa aaagttatta
     9481 aataaacttg aagatgttga attatttgaa gatttaataa aagttaattg ggctgataca
     9541 cttgcaaaaa atccaaagta tgcaaaacaa aagatattaa atcttattga gtgtgaaaaa
     9601 gaatttaaac atataataaa tcaaaaggag tgctttaatc ttaaagattt agctattaat
     9661 ggaaaagatt tgatatctat aggtataaaa ccaggtaaag atataggata tattttaaat
     9721 aagatgcttg aaatagtcat aaataatcca gagttaaatg aaaaagaaat actaaaagaa
     9781 aaagcattaa atatatatac attttagatt caaatataaa aaatttaatt actttaaaaa
     9841 acatagaata aaatacttat ttagataaaa taaataattt ttagagaata ttttagaagt
     9901 tacgattgta tgatttttaa atgcataggc atttactcta ggactataga ctaatataaa
     9961 aaaaaacttt gggaatacta aaaccataaa tttataaaat taatatttta tatactgtaa
    10021 aacagtgagg agggacagta tgcatactca actacaaaag actattggtc tttcagcagc
    10081 tctttctact gttgtaggta tggttatagg ttcgggagtt ttttttaagc cacaagcaat
    10141 atacactaca actaatggag ctccaggtct aggtattata gcgtggcttt taggtggttt
    10201 tataacaata actgctgggc ttacagctac agaaatttca gctgctatac caaaaactgg
    10261 tggtatgatg atttatatcg aagaaatata tggagaaaag ttaggttttt taactggatg
    10321 gatgcaaact gtattatttt tcccaggtac atcagcggca ttaggagtaa tatttgctca
    10381 acaagcatct gaacttttag gaatgagccc aaataatatg gcaaatgtac ttcctatagc
    10441 aattggagtt atactatttt tagcgttatt aaatataata ggttcatcct taggaggaaa
    10501 agttcagaca gtagccacta ttggaaagat gataccttta attttaataa tagtctttgg
    10561 atttattaaa ggtcaaagta gtgaagtatt aaatccattt gtaggagatg gtgtaaatgc
    10621 atcaaatgca cttggacaag tattaatagc tactttgttt gcatatgatg gttggataaa
    10681 tgttggagct atatcaggag aaatgaagtc tccagagaaa gatttaccaa gagcaatagt
    10741 tggtggttta tcattagtta tggcagttta tattataata aatatagctt atctttgggt
    10801 agtaccagca agtgaattag caacagttac ttccccagct acattagtag caacaagatt
    10861 gtttggaaat ataggtggaa aagtaataac tgtgggtata ttaatatcag tatttgggac
    10921 attgaatgga tatttattaa caggttcaag gataccttat acattagctg aaatgggaac
    10981 tttaccagca tctaaaactc ttttaaaagt aaattctgga ggttctcctg taaattcaat
    11041 actacttata actgtgttag cctgtgtata tgcattatct ggtcaattta atcttttgac
    11101 agacttaaca atattttcaa tatgggtatt ttatgtattg acttttatag gtgttatgag
    11161 gcttagaaga caaaagccag atttacacag accatataaa gtccctttat atccaataat
    11221 accaattata gctatattag gtggactgtt tgtaataata aatcaaatat tgacttcaac
    11281 agtcatatct ttaggcggaa tatttataac actattaggt ttaccagttt attattatat
    11341 gaaaaaaaga taactactta atttaagtta gataaatttg ggtaaaggtg aaaattaact
    11401 tttatccaaa ttttttatac tgttatacaa tataagtatt atatattgct tgatgtgcta
    11461 ttttgtttga tttataattt agtaattgat gttttaagat aatttaagaa atgaggagtg
    11521 aaagatgcta ggactttatg tacatattcc attttgtgtg aaaaaatgta agtattgtga
    11581 ttttaattct tataaaatgg acatagattc aaaaaaaaga tatatagaag acttaaaaat
    11641 agaaatggaa ttatatagta ataaattata taaagataat aaatataaaa ataaagaatg
    11701 ctgtagtcta aataaaaatg acaaaataac gagtatattt gtagggggag gtacacctag
    11761 tatactaacc tctgatgaaa taagagaagt atttataagt ataaaagaaa tgtttgatat
    11821 agatgagaat gcagaaataa ctatagagtg taatcctggg acattaacat tagaaaaatt
    11881 aaaaactatg aaagagattg gcataaatag acttagtata gggctacaag ctattcaaga
    11941 aaagcatttg aactttatag gaagaataca tacttatgaa gaatttgaga aaaactataa
    12001 agatgcatta agtgtaggtt ttaaaaatat taatatagat ttaatgtaca gtcttccaaa
    12061 tcaaactcta tgtgattgga aggaaactct tgaaaaagtt gtacacttaa atccaacaca
    12121 tatatcagct tattccctta tactagaaga aggaactgaa ctatacaata tgtatgaaag
    12181 taataaattt gaacttatag atgaaaatgt agatatagaa atgtatgagt atacaataaa
    12241 ctatttaaag tcaaaaggat ataatcaata tgaaatatca aactactcaa aagaaggcta
    12301 taattgtgag cataatattt tatattggga atgtgaacat tatataggga ttggagcagg
    12361 agcttctggc tatattaatg agaacagata caataatgta gaatctttag aagattatca
    12421 tttaagtttg gtaaaaagag aaaaaccaat acaagaaaat gaaattcttt ctgagaaaga
    12481 tatgatagaa gaaaagatat ttatggggct tagaatgaat aaaggcataa aatttgaaga
    12541 ttttaaaaaa aaatttggaa tagattttag agagaagtat aataagcaaa tagaaatgct
    12601 attagctaga aagcttataa atcagagctt tgaaggtata caattaactc aaaaaggaag
    12661 agaaatatct aatagtgtat ttatagaatt tatggaataa tttttaaggt gttgacaaaa
    12721 taaatttata atggtatata atatatataa tctttttagc actcgaactt agtgagtgct
    12781 aacagctagg aggtataata atatggaatt aaatgaaaga aaattaaata tcctcaaagc
    12841 tatagttaaa gattatatag aaacagctga agctataggt tctagaacaa tatctaaaag
    12901 acatgattta ggtgttagtg ctgctaccat aagaaatgaa atggctgacc ttgaagaatt
    12961 agggtattta attcagcctc atacttctgc gggtagagtt ccatctgaaa aaggctataa
    13021 gttatatgta aactctctta tgagtaaaag cgaattggat gataatgata agattcttat
    13081 tgaacaatgt atgaatcata atataaatca tataaaagaa ttgattcatg aaacttctaa
    13141 gctattatcg caactaacaa actatacaac tgtagcagtt actaagagtt taataaatca
    13201 aagtgttata aagcacatac agttggttgc tatgaatgac aataatattt tacttatagt
    13261 tgtaacagat aaaggggact taaaaaaagc taaccttaca actaatgtat atttagatca
    13321 atctaagtta aatttgattt ctgataatct tacaaggaag ctcttaggta aaagtataac
    13381 agatttggat gataatctaa ttgcttttat taaatacgaa ataagtgagt attctgggct
    13441 tatagatgag cttttaaatg ctttgaactc aaatatgaaa gaagaagatt tttctctatc
    13501 attaaatgga gctactaaca tatttagtta tccagaattt aatgatgtat taaaagcaaa
    13561 gtcattttta aatatgttgg aaaaaaagga aacaatagct gacataatta aatcaaaggg
    13621 aatacaaaaa gacaatctaa atataataat tggtagtgat aatgattgtg aactggcaca
    13681 ggattgtagt atagttacag caacttataa tgtagataga gacttggttg ggcgaataag
    13741 ctttataggc cctaccagaa tggattatgc tagaatttac tctataataa attatatgag
    13801 tttattaatt aatagaaagt aaagaaattt taaattgcga ggtgtaaagt cttggataaa
    13861 aaaaatgagc aacaggaagt aagagaagaa aatgatactt ctattaacca agaatcggaa
    13921 actcaagtag agttagaaga ggaagttgtt aatgaagaat gtgaaacatc aagtgaaaaa
    13981 actgatgaaa aagaagttga tgatgaaaat gtaacagata taaattctaa gttagcagaa
    14041 aaaaaattgc aggatgagtt ggatgaatta aatgataaat atcaaagact tcaagccgaa
    14101 tatgcaaact acagaagaag aactcaacaa gagaaagaga caataggcgt atttgcaaat
    14161 gaaaaaataa taactgaatt gataccagtt atagatagta tggaaagagc cttagatgca
    14221 tgtgaagata aggaagatac tatgtataag ggtataagcc ttgtacataa acaattaata
    14281 gacactttag taaaatttgg agtagaagaa atagaagcag aatctaagga atttgaccct
    14341 aatctacatc tagcagttat gcaagaaagt gtagatggag ttgaagcaaa tcaaatagta
    14401 atggtacttc aaaaaggata taagctagga actaaagttg taagaccttc aatggttaaa
    14461 gtttcttgct aagtataaat taaaggttaa attatttaac ctaatataaa atattaaaat
    14521 aagtaaaact taattatata attactcgag gaggatttta gtcatgggaa aaataatagg
    14581 aatagattta ggaacaacaa attcatgtgt tgcagtgtta gaaggtggag aagcacaaat
    14641 aatagcaaat agtgaaggta tgagaactac tccatcagta gtagcattta caaaagatgg
    14701 tgaaagaata gttggagaac ctgcaaaaag acaagcagtt acaaatgcag ataaaacaat
    14761 aacttctata aaaactcata tgggaactga ttataaagta aatatagatg gaaaatcata
    14821 tactccacaa gaaatatcag caataatatt acaaaaatta aaatcagatg cagaaagtta
    14881 cttaggacaa acagtaacag aagcagttat aacagtacca gcttacttta cagatgctca
    14941 aagacaagca actaaagatg ctggtagaat agcagggctt gatgttaaga gaataataaa
    15001 tgagccaaca gcagcagctc ttgcttatgg tatggataaa ttagaccaag aaaagaaaat
    15061 attagtattt gacttaggtg gaggaacttt tgacgtatct atacttgaaa taggagatgg
    15121 aacttttgaa gttttagcta cagctggtaa caatagatta ggtggagatg actttgacca
    15181 aatagtaata gattatttag cagaggaatt taaaaaagct gaaggtgtag atttaagaaa
    15241 tgataaaatg gctcttcaaa gattaaaaga agcagcagaa aaggctaaga aagaattatc
    15301 atcaacaatg agttcaaaca taaacttacc tttcataact gctacagcag aaggaccaaa
    15361 acacttaaat atagatttat caagagctaa atttgaagaa ttaactagag gtttagttga
    15421 aaaaactatg gaaccaacta agacagcttt acaagatgca ggactttcta caggtgatat
    15481 agatgatgta ttattagtag gtggttctac aagaatacca gcagtacaag aagctgttaa
    15541 gaagtttata ggaaaagaac ctcataaagg tataaaccca gatgagtgtg ttgcagcagg
    15601 tgcttctata caagctggag ttttagcagg ggatgttaaa gacttattat tactagatgt
    15661 tactccatta tctcttggta tagaaactat gggtaatgta atgactaaga taatagaaag
    15721 aaatactaca ataccaacta agaagtctca aatattctca actgctgctg ataaccaaac
    15781 agctgttgat atacatgttc ttcaaggtga aagaagtatg gcttatgaca atacaacttt
    15841 aggaagattc caattaacag atataccacc agcacaaaga ggaatacctc aaatagaagt
    15901 tacttttgat atagatgcaa atggtatagt taatgtttca gctaaagatt taggtacagg
    15961 aaaagagcaa aaaataacta taacatcaaa cactaattta tcagaagcag aaatagagca
    16021 aaagataaaa gaagcagaaa tgaatgcaga agctgacaaa caaaagaaag aaaaaataga
    16081 agcattcaat caagctgaat ctactatata tcaaactgaa aaaactttaa atgaacttgg
    16141 agataaaata agttcaggtg aaaaagagga tatagaaaaa gctatagcag acttaaaagc
    16201 tgtaaaagat aatcaagatg ctacagcaga agaacttaag aaagctacag atgaagtaat
    16261 gactaagttc caaaaagtat ctcaagaaat gtaccaaaaa gcagctcaag aacaacaagc
    16321 ggcacaaggt gcagaacaag cacaagacaa tggacctaaa gatgacaatg tagtagatgc
    16381 tgactttaaa gaagtagatg aagataaata agctatataa tatgtaacac taaatgataa
    16441 ttggaacata tatgatttgt gaaaatcata tagatgttaa agatatatgg acaatataca
    16501 tcataaagaa tataatatat catagattat ataacttaaa gtagaatata agaattaatg
    16561 atagcttgta gtttattatt ctacaagcta tcgttttgta aaatgaaggt ggtgtcaatt
    16621 tttgagtaca aaaagggatt attatgaagt cttaggtatc agtaaaggtg cagaagctca
    16681 agagataaaa aaagcttata gaaaattagc aatgaagtac catccagata gaaatcctgg
    16741 agataaagag gcggaagaaa aatttaaaga gataaatgaa gcttatgaag ttctatctga
    16801 tgatacaaag agaaaaactt atgaccagtt tggacatgat gggctaaatg gtcaaggcgg
    16861 ttttggtggt caaggaggat ttggcggtca aggctttggt ggttttgaag atatgttcgg
    16921 agatatattt ggtgacatgt ttggaggaag cttcggaggt ggaagagcaa gaagaagagg
    16981 gcctcaacgt ggtgcagata taagacagag tgttactata tcttttgaag aagctgcatt
    17041 tggtaaaaag atgtctataa aagtaaatag aagtgaagaa tgtgaagaat gtaatggaac
    17101 tggagcaaaa ccaggaacat caaagaaaac ttgttcaact tgtaatggaa ctggtcaagt
    17161 tagaactgtt caaagaactc catttggtaa tatagcaagt tcaagaccat gtagtgcttg
    17221 taatggaact ggagaagtga ttgaatctcc atgtagtaaa tgtcatggaa ctggaaatac
    17281 aagaaaagtt aagactatag aagtagatat acctgctggt atagatgatg gtcaaatgat
    17341 aaaactttct ggtcaaggtg aagtaggaga aaaaggtgct ccaagaggag acttatatat
    17401 tgtagttaat gttaagtcac atccactatt tactagagat ggaaatgata tttattttga
    17461 aatgccaatt acatttgttc aagcaacttt aggtgatgag atagaagtac ctactttgga
    17521 tggaaaagtt aaatatagtg tgccagaggg gacacaaact ggaactgtat ttagacttaa
    17581 agagaaagga atccctagaa ttagaggtaa ttcaagagga gaccaatatg ttaaggttgt
    17641 agttgaaatt cctaaaaaat taaacgataa gcaaaaagaa ctattgagag aatttgcgaa
    17701 ggagtgtggg tcgaacgtcc acgaaaagaa gaaaaccttc ggacaaaaga tagaagatat
    17761 gtttaagaaa aagtagttaa agtagccaat atataatcat atttttaaaa tcttagttat
    17821 ttataagatt gtcaaaggag atattatgat ttttatattg gctatttttg tataaaaaat
    17881 aaatgtgcat aaaataaaac tgaatataaa taattttctg aaaaatactt gtcctaaaat
    17941 atataatatg ctataatata atcaaataaa agaaaggggt gattccagtg ggaacggatg
    18001 tggcactgcc aaatgatgaa gaaaacttta ttgtaatata caaaataaaa ttagatactt
    18061 ttagtgctag attaagtact ggaaaaactc atgagctggg ataattattg taattaccta
    18121 gactcaaact tttagtagta aaatagtaat attatataga caaggtatct aatttttaaa
    18181 tcttttgtat gaattaaaat ttttataaag ggtatatctg attagaatgt aattagggaa
    18241 acctagttgt gaattacttt tagtatatac atgtgtaaag aaatatgtat atggtattgg
    18301 ttattgtgct agatgtgtat gtaaaggaat atgtgtctag ttgggtatat gtaaagaaat
    18361 atacttataa tctatgaaaa atttttagta taaattgcta aaacattgag attgtttttt
    18421 atagaaagtt agtttatacc aactaaaaat gtgcttaaga tttgtttgat gtttaattat
    18481 aaataaggtt gtagataaaa aaataagtaa agacaaaggt ttaaaatact tgctttaaat
    18541 atagtttgtt ttgaacactt gccaaattaa aataattaat aaaatagaca tcttctcata
    18601 gtaaaatata ctgtgagagg atgtttttgc tttgttcata aacttttatg aaaaatttgc
    18661 atagtgtcac attttaatat actatatata taataaaata tagataaaat taaatgattc
    18721 aaaagagaaa ggtgaaaaga gatgtattat ataggtgtag acataggagg aacaggtata
    18781 caagcaggag tagttgataa ctatgggaaa ataattttta ggtcagagtg taaaacagta
    18841 attgaaaaag gctttgaagg aatacttaat gacataaaaa taatgattta taagttgttg
    18901 gaagataata aacttactat gagtgacata aaatctattg gatttggtgt tccaggtttt
    18961 ataaataaag aaggattagt aacttgtgta aatttaaaat ggaataaaaa agcttttaat
    19021 aaagagttaa aaagaagatt tccagatgtt gaaattcatg gagaaaatga tgcaacagta
    19081 gcagcacttg gagaagcaaa gtttggaagt atgaaaggtg ctaatgttgg agtattatat
    19141 actttaggaa ctggagtagg tggaggaata gtaattaatc aaaaagtctt ttctggagca
    19201 catggattgg gttcagaaat aggtcatcaa attataggag aaaactattt taattgtaat
    19261 tgtggaaata atggttgtgt agaaactttt tgttcagcaa ctgcaattat aaagtattct
    19321 caaaaactga tagaagaagg agaaaagagt aggattttag atttggcaga gggaaattta
    19381 gaaaatgtaa atgcaaagat ggtgtttgat gcatatagag aaaatgattt agtggcaatt
    19441 aaagtaataa atagatttaa agagtattta gcaaaaactt ttgcaaacac aataaattct
    19501 ttagacccag aaattatatc tataggagga ggcatttcta aatctagcga tataatactt
    19561 gatggaatag aagatttggt aagaaaattt gtattataca aaacagaaga tatagctaca
    19621 attacatgtg caactttagg ttcagacgca ggaattatag gagcagcttt tttataatgt
    19681 aaatgaactg cttattggag gcgtgatgat atatgggtaa aacaaatgct agaagaacgc
    19741 tttttttgat agcaataggt tcaggaacta tgctgaatcc tcttaattct tctatgattt
    19801 cacttgcttt acatagtata caaaatgatt ttcatattag ttttacaact gtatcttgga
    19861 ttgtttcagc attttaccta gctagtgcta ttgcacaacc agtttcaggt aagataggag
    19921 atttaatagg tagaaaggtc ttatttttga gtggtttgat gcttgtaatt ttatcagcat
    19981 ccatagtacc acttgttcaa tcattcttta tattgatttt tataagagta attcaagcaa
    20041 ttggaacaag taccctatat ccatctggag ttgctcttat acaaaataat ataaaagaaa
    20101 gacaatcttc tgcattagca gttctaacca tttttgcttc aactacagca ggattaggtc
    20161 cgacacttgg aggattattg ttggacttag gaggatggca tgctatattt cttgtaaata
    20221 tacctgttgt tttggtttct atatgcttag ggtatttttt attcccaaaa gaagtaaaag
    20281 aaaagaaatc tataaaagaa actttaaaaa atgttttgtc aagattagat attattggca
    20341 tacttctatt ttcaattgca atgattttta tattactatt tttgctatct atgaaggagt
    20401 cttttaactt ggaacaactt gtatttggta taatactgat gtgtcttttt atttggcatg
    20461 aattgagaac aaaattgcca tttatagata ttaagctttt tgtaagtaat cctaaattgt
    20521 caaaagttta cttgcaattt attatattaa atttctttaa ttatattttg ttttttggtc
    20581 ttcctagtta ttttcaagat gccttacatt atagtgcaaa gtcgactgga ttatttatgc
    20641 tatttatgtc tggtataggt atatttatat ctccattaac tggaaaatgg atagataaat
    20701 ctggaactag atttcctctt gttacatcat caatctttat gtttattagt gcagtacttc
    20761 tttcagtagt ttttatccat atacctgtaa taggaaaggg tattatatta tcattagcag
    20821 gtattagtta tggagttggt aatgtagccc tgcaatcctc tatgtttgaa gaaagtcctc
    20881 gtgacagtat agggacagct tctggtctgt ttcaaactag tcgttattta ggttctattt
    20941 tagcaactgt tttacttgga atggtatttg aagtaaatat aacatcagaa caatttcaga
    21001 tattaggtta tgttatggtg gtcttaggta caataagttt tttattaaat tttatattaa
    21061 agaaagaatt aagaaaagta gaatagtgga tttatggatt taataagtct aataactgat
    21121 aagtttaaaa atattgtttg taaaacataa ctggtttgat atttattaat tctaagtttt
    21181 gaagcataga gtactcgata agtatacaat attttgaatt aaaattaagc agaaatttga
    21241 actagtcttt caaatctctg cttaatttag tagttaaatt tttttataga gaaaataaga
    21301 tttgacactt agataaaaaa tcattgcatt ttcaaaattc tttaaatcaa acccaagtat
    21361 ctcattaatc ttttccaatc tatatactag cgtgtttcta tgtaaaaaca tactagtaga
    21421 tgtcttagaa atatttaaat cattatttat aaattttatt cctgtatata gaagttcttc
    21481 gtcaatagat ttaatcttat taaaatctat taatttattg agtatattat cctcattaat
    21541 taaatctaaa gttttatatc taataaagtc aaacaaattt aaaaacttat tttcagcgtt
    21601 gtcttttata atatgaggta gtaaatcaga acataactgt aatctaaaat caaaatcagc
    21661 tttactatct aattcaccaa gataaaaaat ataagtactt tgataagttt cagtttcaat
    21721 tatattttgt gtagttacat taatatctaa gttatattta gaatttacta taaaaaaacc
    21781 attgtgttgt attatattta tatcttcaaa taaattataa aaaatatttt ttagatattc
    21841 aaagtctata tgagattggt aaattaaata aaagttgcct tttaaattat cgagattatt
    21901 tttatctaga aaatcaataa cataaatagc attattgaaa gtaactaaat ggctactagc
    21961 atctaacttt tggttttcat atggatagat atttattttt ttattaagct gtctttctaa
    22021 aaaatctttt aactcttcca taaagtctcc ttaaaaataa gattatattc ttatcttata
    22081 gctaaagtag tttctttgtc aaatatgtgt actctactat tgtcaactga aagtgttaag
    22141 tcatcaccaa cattaattct gtttttactg tcaaatctaa ttgttatcgt attttcgcct
    22201 agttttaagt gagcataagt ttctgctccc ataagttctt ttatttcaat tcttgattta
    22261 aaacaagtat ctggattaga tttaataaaa gtatcttcta catgaatatc ttctggtctg
    22321 atacctataa caacttcatt attaatataa ttgtctttta ttaaatcata gtgtttttct
    22381 ttattcaatt taagcttaat atgttcattt tgtgcataaa tttcatcatt ttcttctatt
    22441 aatattacat caataaaatt catctgtggt gctccaataa atcctgcaac aaatatatta
    22501 gctggataat cgtatacatc ttgtggagtt gcaatctgct gaactactcc atccttcatt
    22561 actacgattc tatcagccat agtcatagct tcaacttggt cgtgtgttac atagataaat
    22621 gtagttccaa gctgttggtg tagcttagtt atctctgttc tcatagcagt tctaagtttt
    22681 gcatctaagt tggatagagg ttcatccatt aagaatacct taggatttct aactattgca
    22741 cgtcctaagg caaccctttg tctttgtcct ccagataatg ttttaggttt tttatttaaa
    22801 agaggtagta agtctaatat tttagcagct tctttaactt ttttgtctat ttcatcttta
    22861 ggcaaatttc taagtttaag tgcaaatgcc atgttttcgt aaacagataa gtggggatat
    22921 aaagcatagt tttgaaaaac catagctata tctctatctt ttggttctat attattgaca
    22981 agtttatctc caatgtatag ttctccttca gagatttctt caagaccagc aatcattcta
    23041 agtgtagtcg atttaccaca accagatggt cctactaaaa cgataaattc tttatcttta
    23101 atgtctatat ttatattttt tactgcgtta aatccatttg agtaaagttt tgatatattt
    23161 tttaaaatta cttctgacat aatatcctcc ttgatattta aattttaatt atatagtatc
    23221 aaattttttt attatattaa atgtgtaaaa tgactaaatg tatttgttta atatgtatat
    23281 ttagttttta gcaaagaata aaactaacag tagaatatat ttaaaaaatt aaaaaacaaa
    23341 attaaattta ttatcaaaaa atcattttat gatatgtttt atttttatat tacaaataga
    23401 gaataatgaa ttatactaga aagtaggagg tgaaaatatg agcagaattt caatttttat
    23461 ggaatcatgt aatggcaaat ttccaaatga aaattcaatg ttgtcagttt cctttataaa
    23521 aaatatttta aatgcagaaa acaaagattt tgctaaaaac atatttaact atggggaaga
    23581 aagaaaaaac aataagcaaa taaaggatat aaatacagcc atttacatac caaatcttat
    23641 aagaagcaaa aatgagttac ttgttgatgg agatataata ttcaatataa gtttttataa
    23701 ttattctatg ttcagtaaat tatacaatgg aattttaaaa gtaaaggagc tagaatataa
    23761 aggttataga tttaaaataa aaaatataaa aatacataaa gaacacgaga taaaagaaaa
    23821 tggtgttata tttaaaacta tgtctcctat aatagtaaag aataaagaag gtaaatattt
    23881 agatgtagaa gattcaaatt atatagaatg tttaaactat atagctaatc taactctgga
    23941 gagtataaga ggtagtgggc ttagaaagcc attggaattt atacctatta acttcaaaaa
    24001 aagagtgtta aaagaaaaga ttcgtggatt taaagtgaga gaatattact atataaatgc
    24061 ttatgcagga acattttttt taaaaggaga tatggaagat ttaaatgcac tgtataaaat
    24121 gggaattgga tatagaagga cagaaaatgc aggaatggtt gatatattaa agtagcgagg
    24181 tgagagaaat aaaagctaaa ttttatagat caggtgatat tgtaagagat attggcattg
    24241 tttactttta tgaattacta atggatttaa aaaacgaact agaaaaaaat gattataagc
    24301 taaaatttac ttgtgagtta aatagaaatt atttatcttt agaatctgca gaatatatag
    24361 accctaagta tatatctgat tatatattag aaaatcgact ttttaaggta tttaaaaatg
    24421 ggaaaaagga aaccttagaa aaaatattta gtaatataga taatttaacg tatgtaaatt
    24481 ttattgaaga attagataaa tcttctgcaa ctgctaaaca aaaggaagat attaaaaaag
    24541 attttaaaaa caggaggttt ccatatgtta gaaatagtgg taagtatgga ttaaacacga
    24601 gtttagaaaa tatggaaaca aatgtaaaaa gaatagtaga tactgtaatt aaatcaaata
    24661 tagagataga tgaaatagat aaacttgatt tgacacaata tgaagaaaaa gatagtgtat
    24721 gtaatgtttg caatataaat aaaacaacaa aactagatat tgatttaaga gaacgaaagg
    24781 actctaagta taacttttta tttagaggtg cagaaaaatc aggctttaaa agaagtggac
    24841 aagttgaaag taatatttgt tttgagtgtg aatttttcaa cttaatgtgt cttttatata
    24901 taaatttaaa aagaccaatg gtttttgcat atacgaatga tttaagagaa ttagcatttt
    24961 taaatcataa gataatgctt aaaagaaaaa tgtattcaga taaatcattt tataaaaaac
    25021 ttttgcatga aaaaataagt tcaattagac tatatagctt tgatattgat acgaataaag
    25081 gtataattct aaagtttgat tctattatag agtataaaga attattaaaa aaaattgaac
    25141 ttatagatat tatagataat tataattttt caagagagcc aggtaatact agaaatttgg
    25201 gtaaaagaat gattgataat gggaatttat caaatttaaa agaattatta cttgataata
    25261 taagtgtttt aaagcaatca actggaactt ctcgagaaat ggattttgta tctagctcat
    25321 ataatatcgg tttatatata aaattgtgtt ggattgtaga tggaggggag gagtataaaa
    25381 tgaaaaacta tatggaaagt aatttaatat attcaagagt aggtaaagac ttatttaata
    25441 aaatgacaga tgaatccaga agaaaaaatt tttctatgaa agtgattcaa ctacttaagt
    25501 ctaatgatag aactcagcta tttcaaacta taatgcatgt gttagtttct aatggaatct
    25561 taataggaga agggtttgta gaaggtctaa tgcagagttc tgaattagaa ttaaatacga
    25621 atgtaggtct atttattcaa gaaatcatga aataaaaaag ggggaaaatt taaaatgaat
    25681 gaaaaaagag taaaaggagt aacattaact atactgacag aaagcccagt tccactttca
    25741 tatgaccaag ggtatggaaa ttatacacca ataaaaaaag aacaatatag agaaaaaata
    25801 catgcaaaaa ctagtatagc cacaataaca tatgatttaa gaagaatgct ccaccaagaa
    25861 tatggttgga atttaagtaa tattgttttt ggaaaaaaag gaaatatata tccatctatt
    25921 aagaaaaatg taggatgtgt agatgaaaat ggattagaga ctgatgtatt tggttattta
    25981 ataccactta aagataaagg ttctataagt aaagcttctc cacttagaat aatacctttt
    26041 aggtcattaa atccatataa aggttcaaca cagctaataa caaatagagg ctttttaagt
    26101 agtgaatttg gtagaaaata ttatgatgag aaggaagaaa atgaagtacc tagagatgaa
    26161 aactttccaa catcacaagc attagcaata gaagagactt tatcagatta ctacgtttat
    26221 acaataacat tggagcttga tagaatagga gtagtagaag tagaagatgg aaagttactt
    26281 ttaccagaag aaagaaaatt tatgagtaag gagttaagag aaaaagcagt aaaagatata
    26341 ttagatgcaa ttactgtgtt tacaagaaac ataaaacatt catcagtact attaaaacca
    26401 cttgcagtaa taggtggagc ttttgataaa gttgtaccat ttttttggga tgatgtagat
    26461 tataatgctg atagtggtga gataaattta gagggagtca tagaaactat agaaagttat
    26521 agccttaaag aaagtaacac aatacttgct atcaatgata gattaaaaat ttctaataaa
    26581 aaggaattaa ataagtttaa tttaagtaaa taccctgtaa aagagattaa aaatctagca
    26641 gatagattgg aaattggaga agataatatg tggtatttaa aagagtagga ggttttttga
    26701 attatgaaag tattacaatg taaacttaag caaccaactg ctcactatag agacccaaaa
    26761 gtatttcaaa atgaatatat aagtacttta aatttaccat ctaagaccac aataatggga
    26821 atgataacgt atttatgtga tagaagatta aactctgata tagatatagg aataattgga
    26881 acacatcatc atagagaact agaattttca agaggagaaa acattgattt ttggaatgaa
    26941 tatataaaaa tgggaaaagg taaagataaa gaaaagtttt tgcttaaagg aaactactat
    27001 gattactata aagagcataa agctcaaaat agcatattaa actatgaagt tcttaaagaa
    27061 gtagaactga ctatatttat ttcttgcaag gatgatgaag aacttgaatt tattagaaaa
    27121 aagcttgaaa gtccatgtaa atatgcaaat ttaggaagaa aagaagattt tgtaatacca
    27181 agtgaaaaag ggtgttttgt gaaagaagtt aagttaaaag aggttatacc tatgaatact
    27241 cgtgatgcta taaaagaaaa tataaaatta aagaatacat atgtaagagt tgacttaaga
    27301 gataaagaga atgtcgagac tataataaat caaggtgtat tgattgcatt gcctcataaa
    27361 tataaagatt tagaagcaaa tagagatgat agagtttatg agttttgcca ttatatatat
    27421 gttgataatg atggtatata tcctaaaaat attaaggtaa atgtatgtat tgatacaaaa
    27481 gaagttttta catggcttta aattattttg aaagataggt gtttatcatg aaaaatatca
    27541 tgcaaaaaga aatattagct aagtcataca atttaagaac taatcaacaa gaacaaacat
    27601 tagttgaaca tattaaggat ttatttgaag tattagaatc tatattagaa ttaaatctat
    27661 attcagataa agatgtagag atactaaaaa tatgttgtgc tttgcacgat ttaggaaaaa
    27721 ttaattcaat tatgcaacaa aaaatggaga ttaataataa aatatcgtat agttgctcag
    27781 aagaagagag gaaaaagtta gagtctgaca aaaaatcttt aaaaaagata gcaagacata
    27841 atatattttc tggagcattt ttaaaagata tattagaaaa aatgaacttg tcagaagaag
    27901 ataagttata tatatataaa agtataatgt tacatcatgg aaactatgaa gattatatga
    27961 ggttaagtat tagtaaagtt caagaagaaa tttatgagta tattgaaaaa ggcattttag
    28021 aaaaagaaga gtttaatctg aaagatatag aaagttatat aaatagcatt ttaaatgtag
    28081 actttaaatt tggtgaagat gtattggatt atgattacat agataaatta agtgaaagta
    28141 tgtttataga cagtgattat aacaatggtc aaatagatga ttcagtttta aattatagaa
    28201 agtttaagta tattttatat aaagggatgc tgaacttaat agaccatagt gcatcaagta
    28261 gacagaaagg tataaaattt tataacgatt ttactgatga agaaattgat aatatgattt
    28321 taaatgagat atataagagt cagggtaatt tggaaaaaaa taatatagag ttcaatacta
    28381 tacaaaaaag gttgagagaa ctttctggaa gaaatgttct gactgttgca tttacaggtt
    28441 caggaaaaac agctgcagat tatagaaaga cttttaaaag aaaattcttt ttagtgccaa
    28501 ataaaatatc agcagaaagt ttttatagaa aaaatatttt tcaaaataaa aatgatttag
    28561 atacaagaag tagtaatgat tacattggat tacttcatgg agatataaac ttatattcag
    28621 agaatgaaga taatggagaa catgattttg tattgacatt aagggatata gatttgagta
    28681 taaacttttg caaaccttgt gtaattgcaa cagttgatca gttattactt agtatgttta
    28741 aatttccggg atatgaaaaa atattcgcag ccgtaaaaaa tgcatctata actgttgatg
    28801 aagtacattt attggaacca aagatgtttt tgattttgat atattttatg cagtttgcat
    28861 gcaagtactt agatgttgat tttcacttaa tgacagctac acttccaaaa tcatataaag
    28921 agcaaatgat aaacaaggga attatttttc aagaagaaag taatgaaaat gttactgata
    28981 aaggagaaat agtttttatt gagagcaaca aggaagaaga gatttgtgaa ggtaaagatg
    29041 taaaggtttc ttttataaag gaaaaagaaa tcaagtcaat agttgaagat gctttagaaa
    29101 ataaacaaaa aattcttata ataaagaata ctattgattc agtcaataga acatatgagt
    29161 ttttaaaaga aaatttatct gataagtatg gtggtgtaga tatagatgtt ttacatagta
    29221 gatttaagtt caaagataaa aaagagaaat atagtaaaat attaaatgga gagggtgata
    29281 tttggatatc aactcaatca gtagaaatat ccttggattt ggatttcaat ataataataa
    29341 gtgatttagc aactatggat agcttaatac aaagaatggg tagatgcaat agaaataata
    29401 agtatgaata tggaaacttt tatattctac ctagtgaaga taaaatttat gacaacaaac
    29461 ttaagagcac aactaaaaac atcttaaagg acatattaaa aactaactct atttttacaa
    29521 tgggaattag aaaaactatt ttggatgatt actatgataa tagtgtagtc aaaaaatatt
    29581 ttgaagagaa ttttataagt tgtgataaag aaattaagaa tatttatggt gtaaataaag
    29641 aaatttttga tggattggat ttaattttta attttgaacc ttacaaaaat attgttgata
    29701 gtaagaagga agcagctaaa atttttagag atgttgatgt tagttacaaa attattctgg
    29761 aagaagattt ttataaggaa gatagagagt tacaacaaga ttcgattcaa gtatcagggt
    29821 ttatatttaa tagattatat tattatgggt taataagcaa agtagaagga tacatggtac
    29881 taaaatctag tagtaagttt gagtataata gtactgtagg cttaattttg aagtgagcat
    29941 atgtttaaat ataatatacc tttagacatt gaaaatacaa aaagtactac tgtaagctca
    30001 ctgtaaaaac tattttttaa aaggaaaaat aagttgtgag atagagtgtt tacaagtgta
    30061 tatagataat aaatttgagg tttaagatta actaagtggg tttcaggtac atcgcgaaaa
    30121 taattataag ttggagattt tgtatgttta agattaacta agtggatttc aaatattgat
    30181 atagtagata taatagaagt tttattatta ggtttaaaat taactaatcg gatttttaaa
    30241 tattctgact attatataag gatattatta gattgaattt aaaaccaata atataaaaca
    30301 acaaaatatt atatttatga tataataaaa gttatggaaa aacaggaata ttactataga
    30361 gaagagaggt aaacttatga ataattggat agaagtaact ataaaaacaa caacagaagc
    30421 agttgaacct ataacgaata tactatatga acaaggagct ggaggagctg taatagaaga
    30481 cccaaaagac tttttattcc aaaagaaaaa tgaactagac tgggattatg ttgaagaaga
    30541 agtatttaaa aagaatgaag aagatgatgt tcttataaaa acttatgttt ctgaagaaaa
    30601 aaatgtgatg gaatttgtcg aaataataaa gcaaaaagtt ttaggattaa aagattttgg
    30661 tatagatata ggtgaaggaa gtgtatcatt ggaccaagta aatgaagctg attgggcaaa
    30721 tgcatggaaa gcatactaca aaccaacaaa agtaggacaa agggtagtag taaagcctac
    30781 atgggaagat tatgctatgc aagaggggga tttaatcata gagcttgacc ctggaatggc
    30841 atttggtaca ggtacacatg agactactag tatgtgcatt agagaattag aaaagtatgt
    30901 gaataaagat tctaaagtat ttgatattgg atgtggtagt ggaatccttg caatagcagc
    30961 agctaaatta ggagcaaaag aagttgtagc tgtagattta gatgaagtgg ctgtaaaagt
    31021 tgcaaaagaa aatgttcttg aaaataaagt tgaaaaaagt gtatctgtaa tgcatggtaa
    31081 tttaactgat gtaataaaag ataaagcgga tgtaatagtt gcaaatataa tagctgatat
    31141 aataaagata cttgcaaaag atgttcaaaa ctttatgaaa gaagatgcta tattcatatc
    31201 ttcaggtata attttggata aagtagaaga agttaaagaa agcttaattg aaaatggatt
    31261 tgaaatagtt gaagttcaaa aattaggtga atggtcagca atagtttcta agcttaaaaa
    31321 ataagggata tggtgacgta taatggatag attttttgtt gaaaaaaata atataaatct
    31381 acaagataaa acttgcacta tagaaggtga agatgtaaaa catatttcaa aagttttaag
    31441 atgcaaatta ggtgagaaac ttgaaatatg tgacaagaat aataatgagt atatttgtga
    31501 gataatgaat atagataaga gtatagttaa tttagaaatt ttagaaaaag ttgatataaa
    31561 tagagaatca gaacttaaag taaggctata ccagggactt ccaaaagctc caaaaatgga
    31621 aataatactt caaaaattaa ctgaagtggg tgtagaagaa ataatattag ttcaaactaa
    31681 gagaagtgtt gttaaagttg atgacaaaaa agaagataaa aaatttgaac gttgggaaag
    31741 aataatttat gaagcagcaa agcaaagcaa aagaggtaag ataccaaaat taagaggtgt
    31801 tttaagtttt aaagaagctt tagaagatat gaaaaaaaat agtgtaaata tttgccctta
    31861 tgaaaatgaa agaacagttt caataaaaca tgcactaaaa aaatgtgatt ctaatataga
    31921 tagtgttgga atttttatag gtccagaagg tggattttct gaagaagaaa tagaacaaat
    31981 acaaaaaaat aattgtaatg ttgtatcatt ggggcctaga atattaagaa ctgagacagc
    32041 ttctgttgta gcatcaacaa tagctttgta tgaactaagt gatttaggag gagaaaaata
    32101 aattgaaaaa agtagctttt tatacacttg ggtgtaaagt taatcaatat gaaacagaag
    32161 ctatgctaga actatttgag aaagatggtt atgaacaagt caatagtgaa gagtatgctg
    32221 atgtttatgt tataaataca tgtacagtta ctcatatgag tgatagaaaa tctcgtcaat
    32281 atataagacg agttaaaaag aagaatccag atgcaataat agccgttgta ggatgttatt
    32341 ctcaggtatc tccggaagaa attttggata tagaagaagt aaatttagtc atgggtacaa
    32401 atgatagaag aaagattgtt gaagaaatta aaaagataaa ttcaagtaag aaagttagta
    32461 cagttgatga cataatgaaa gttaaagctt ttgaagaaat agaaatcagc caaactaatg
    32521 gaaagactag agcatttatg aaaatacaag atggatgtga cagattttgt acttattgta
    32581 tcattcctta tgcccgagga cgcgttagaa gtagagatat tgatagtata gtcgatgaag
    32641 ttaaaaaatt ggctaataat ggctataaag aggttgtatt aacaggaata catgttgcct
    32701 cttatggaaa agatttaaag gatagggata ttaaacttct tgatgtaata aaacaaataa
    32761 accagataga aaaaatagaa agaattaggc ttagttctgt tgaaccaatt ttatttacag
    32821 atgaatttgt aaatgaagtt ttaaagatgg ataaagtttg tcctcattac catttatcac
    32881 ttcaaagtgg atgtgatgaa actctaaaaa gaatgaatag acgatacaca actttagagt
    32941 acaaaactat tgtagataga ttgagaagta aaatgccaga tgtggcaata actacagatg
    33001 taatagtagg ttttcctgga gagacaaatg aagagtttaa aaaaacgtac gagtttttaa
    33061 aagaaataga gctttcacaa atgcatattt ttaaatattc accaagaaaa ggaactccag
    33121 ctgcaactat ggaaaatcaa gttgaccctc aaatgaaaca ctttagaagt gaacaacttt
    33181 taaatttaag taaagtaaat tttaataaat ttgcaactaa atttatcggc cgtgagttgg
    33241 atgttttatt tgaacaaaat atagaaggca ataaatatga gggattaact tcaaattata
    33301 taagagttgt tgttgaaagt gacaaaaata tacaaggtca gatattaaaa gtgaaaataa
    33361 atgatgtaaa agatgaatat gtagaaggaa ttttgctata acatgtagaa attataatat
    33421 ttataagata ggaggtggaa agaatggatt gtattttttg taaaatagcg aacggagaaa
    33481 taccttcaac taaagtttat gaagatgata gagtcttagc ttttaatgac ttgaacccag
    33541 ttgctccata tcatatatta gttgtaccta aaaaacatta tgatagttta attgatattc
    33601 ctgataaaga gatggacatt gtgtcacata ttcatgttgt tattaataaa atagctaaag
    33661 agaaaggttt tgaccaaact ggattcagag tcataaataa ttgtggaagt gatggagggc
    33721 aagaagttaa acatttgcac tatcatattt tagctggtaa aaagcttcct aattacgaag
    33781 cgggacaaaa ctaaactaaa ttattgaaaa attgagttcc ttcttgataa aaatacttga
    33841 taaaagtaaa aatttagttt ataataaaca aagtgttagg ttgtaatgca tattatgcaa
    33901 aaagaacata gttacagtcc cagcataatt gcgctattgg agggagggaa aaagaaatgt
    33961 cagaagtaag agttagagag aatgaaacat tagacagcgc tttaagaaga ttcaagcgtc
    34021 aatgtgcaat gtctggcatc atgtcagaag tgagaaaaag agagcactat gataagccaa
    34081 gcgttaagcg taagaaaaaa gctgaagcag caagaagaaa aaacgctaag aaatagtagt
    34141 aaataagaat aaagaggtga aggggatgtc ccttaagcaa aagttacaag aggatttgaa
    34201 atcttcgatg aaaaacaaag atacagtgag aaaatctgta gtaactttaa taagagcttc
    34261 tataaagcag tatgaggttg ataatagggt cgagcttgat gaagatggaa ttatcgatgt
    34321 aatagcaaaa caattaaagc aacgtagaga tgcattagtt gaatttgaaa aagctggaag
    34381 agaagactta ataaaagaaa cagaaggtga aattgaagtt ttaaaagagt acctacctca
    34441 acaattaagc gaagaagagt tagaagaaat tgtaaaatct actatatccg aagtaggggc
    34501 aacttctatg aaggatatgg gaaaaataat gtcagttatc caaccaaaag ttaaaggaag
    34561 agctgacgga aaacttataa ataagttggt aaaacaaaac ttacaataga ttgatatagc
    34621 ctagagagaa atctctaggc tttttatagt ttttgggaat aacgagtcat atttgagcat
    34681 atctataatc aaagaaaatt ttgaaagaag gggaaaaatt tgattatatc agtaaaagag
    34741 attaggaatt ttttgataaa catatttata ccactaataa taggttactt aagtagcatc
    34801 ttaacaatga ttatcagtgg aacagatatt tcaacctatt atttacaact cacaaagcca
    34861 agctttgcac caccagcttt tatctttcct atagtttgga ctatattgta catattgatg
    34921 ggtatatctt catacctaat attaagaaag ggttacaact tacctaaagt aagagatgca
    34981 attttttatt atggattaca acttgtatta aactttattt ggagtatact attttttgga
    35041 tttggactta gatttacagc tttgatagat ataataataa tgattttggt ttctataata
    35101 atgatttcga agttttctaa aatagataag agatctggat acataaattt gatttattta
    35161 atgtggcttg tttatgcagg atttttgaac tattttatat ggtttattaa taaatagaat
    35221 gtaaagattt tgtaaattac cctgtacttt taataatatc ataacaaacg aaaaataaat
    35281 agactattaa aaataatcat tttcatatac aataatatta atttaaatac aataaattta
    35341 taaaaattgt atttaaagat taacatatta aagtattaga attggaaagg cttgaaggga
    35401 gaggttttta tgcaaataat agtatctggg agacaaatga aattaactga cggaataaaa
    35461 ggatacgtag atggaaaatt aagtaggtta gaaaaatacc ttgatcctga atcagaagtg
    35521 aaagtaacag taagtgcgaa aaaggataga caaaaagtgg aggttacaat aattcctatt
    35581 aacggtcaaa taataagagc agaagatgta gaagatgact tatatgcagc aattgatatt
    35641 gtttgtgaca aattaagtag acaagttgtc aaatataaaa ctaaagttaa agacaaagtt
    35701 caaaataata agagcataag atttgaaaat cttgacttta tagataatag cagtgaattt
    35761 gatgattatg attatgatga tgaagaagat gaaaatatag taatagaaag aagaaagaaa
    35821 tttaatgtaa aacctatgag ttctgaggag gcgatacttc aaatggaact agtaggacac
    35881 aatttctata tgtttagaaa ccaagataat tttgaaataa acatagtgta taagcgtaaa
    35941 gctggtggat atggtttaat agaacaagat taataaaaat tgtatacgtt tagattttat
    36001 ataagaaaaa ataaaaaggt aatcatgttg attttttatc aatatgatta cctttttctt
    36061 gtttaaataa tatattagat attaggtatt tattatataa aaattttaaa actaatctgt
    36121 tacaacatca ataaagtgca taaataccta tttcaagcat aaaattaatt aagggggtaa
    36181 tgcttatgtt agaaatatcc actgatttac aagtaaatca accagttatt actgttacaa
    36241 gtaatacgtt tattagtata gaaaattatc tatcaatatt agaatatgaa gttgatttaa
    36301 taagaataaa gactaaagtt aaaacaatta aaatatctgg ggataaactt tcacttaagt
    36361 atattactga tagtgagata ggtataaaag ggattatcta caatgttgag tatgttgatt
    36421 aggaggagat acacttgata agttttataa ggggatacta tgttatagtt gtggaaggag
    36481 taggactcga acaattttta aatcatctta taagaaatgg gataagtgtt tacaatgtaa
    36541 ctagaataaa aaatactaaa atggagtttc atatagatag acaagatata aaagacttta
    36601 agaatgttta tagaggaagt aagtttgata taaaggtaaa gcaaaaaact ggggtccctt
    36661 ttattatcaa aagagtttat aagcacaaag gtatgtggat ttgtgctctt gtttctttat
    36721 ttttattgat gtctacatca cagtttgtga cagatgtata tatacaatct cctgaaggta
    36781 taaaaaaaga agctcttaga aatgagcttt ataaggttgg agtaaggcca ggagtctata
    36841 agaagagtat tgatagaaaa gaagttagag accatatgat gtcaaaattt aatgatgtgg
    36901 catatttatc tatcaatgta aaaggaacaa atatatttgt tactgttaca aaaaaggcag
    36961 aatccctaaa atctacagac caatcaaatt attgtaatgt aattgcttta aaaaatggta
    37021 taatagaaaa ggtaatccct agaagtggta aatcagttat taaatctgga gacatagtcc
    37081 aaaagggaga tgtcttatta aatggagcta ataccaagtc aataccagaa gtatgggcaa
    37141 gtacttttta tgagtccaca aaaaaggcaa gttatgtaga tactgtaaat aaaaaaactg
    37201 gagaaaagaa aaatatatat acactaagtt tttatgataa agagtttaca atgagaaaaa
    37261 atataaaata taaagattat gttgttgaaa ataaagaaaa aaaactatca ataggaaact
    37321 atacttttcc aataaagata aaaacgagta ctttttatga aacaaaaaag gttgaagtaa
    37381 aaaggaataa agaagagtta aaaaaagaat tatctgaaaa agctttaaaa gagttagaat
    37441 acataatccc agcttcggct agaataatag atgtaaaaca taactttaag gttaataaaa
    37501 atatgttaga atatttaata acagttcaaa ctagtgaaaa tattgctaaa atttatcctc
    37561 ttagtaagtc agaagcagaa aggtttataa aggaagaaag taaaccagat gaaggtgaag
    37621 aggaagttcc ttccaatcca gaaaaaagac cattaaatga tataagaaat gagtttgatg
    37681 aggataataa ggataataaa gaccaaaaca attctgatga aaataatagt aatcaaaata
    37741 gtaataatag tcaaaataat aatagcaata acaactaata aaattaaact taaaatctta
    37801 ggaggactaa ttcaattgat aatacaaaag aaatttacaa tagcagatgg taactttgaa
    37861 agagagttat ttggcaactt tgatgaaaat gtaaaattaa tagagaagac tttaaatata
    37921 gatgtaatac ttagagaagg caatataatt ttaattggag aagaaaaaaa tgtagattct
    37981 gcattaaaac ttatgaatga attacaccaa actgtatcaa atggtaagca tttagataag
    38041 cagagtattt cttattcatt atctcttttg cttgaaggaa gtgaacaaaa aataaaagaa
    38101 cttgagggga caatcgtcat aactcaaagg ggaaaagctg ttcaacctaa aactttaggt
    38161 caaaaagaat atataaaact tatagaaaat aatgatataa cttttggtgt tggacctgct
    38221 ggaacaggaa agacttatct tgcggttgct atggcagtaa aagcttttaa aagagatgaa
    38281 gttagtagaa ttatacttac aagaccagct gtggaagcag gagagagtct aggtttttta
    38341 ccaggagatt taaaggacaa agttgaccca tatttaagac cactatatga tgccttattt
    38401 gaaatgttgg gtgctgataa atttaataag tatttagaaa gaggtactat tgaggttgca
    38461 ccacttgcat ttatgagagg tagaacactt gataattcat ttataatatt ggatgaagct
    38521 caaaatacta cttctgaaca aatgaaaatg tttttaacta gacttggatt tggctctaaa
    38581 gctgtagtta caggagatgt aactcaaaca gatttaccac aaaataagaa gagtggtcta
    38641 atacaagcta cagagattct taaaggtgtt ccaggtattg ggtctataat gctaacagat
    38701 agagatgttg taagacatga gttggtacag agaataataa gagcttatga gaagcacgac
    38761 aaaagagaag aatttaaaaa agaagaacgt aaaaaagcga aaatgcagga aaagactttc
    38821 aaaagaaagt aaaagtgtag taatatagat atatagcatt attaatgaat aaaaagtagg
    38881 tgtagtgaat ggatttgata ctagatgata gacaagataa attagaagta agtgaggagt
    38941 taattgaaaa gataaaggat ataatcatag aatgtttaga ttatgaagga tatgatgata
    39001 attatgaagt gagtctttct tttgtagata ataaagagat tcatgaatta aatagagaat
    39061 atagaggagt tgatagagtg actgatgttt tatcatttcc tcttttaagt gatgattttg
    39121 aagatgttga gttagaagaa gaatccctag gtgacatagt agtatctctt gaaagagcct
    39181 tagaacagag tatagagtat aaccatagtt ttgaaagaga agtatgtttt ttaatatgtc
    39241 atagtatgtt tcatctttta ggttatgacc acgatacaga tgaaaataca aaagaaatga
    39301 gagaaaaaga agaacacata ttaaataagt taaacataac aagggagtag tttttatgaa
    39361 accagaaaaa actcgtcaag gtataattaa agcatttaat gcagctatag aagggatatt
    39421 gtatacattt aaatttgaaa gaaatatgaa aatacattat ttaggttcag ttgctgttct
    39481 tataataagt ttgtttttta acttttcaaa attagaaatg ataatgttac ttatgtccat
    39541 atgtttagtt gtagttgctg aaatgtttaa tacagctata gaaaaagctg ttgatttagt
    39601 aactgatgaa tatcatgttc ttgctaagat agcaaaagat gttgcagctg gaggcgttct
    39661 agtggcagca ctaaattcag tagtagttgg atatattttg ttttatgata aattgacaga
    39721 tatatctgga atattaattt ataaaataag agaatcagaa ttacatataa ccttgatatg
    39781 tatattattg gttcttatag ctgttgtagt tgtaaaagca ttgacttcta caggtactcc
    39841 tctaaaagga ggaatgccaa gtggtcatgc tgccttagca tttgctatag caactgcaat
    39901 tacacttatg actgaaagag ttgttgcctc tactcttgca tatataatgg ctgtattagt
    39961 tgcccaaagt agaattgaag gaaaaataca tacattttgg gagactattg ctggagcttt
    40021 gttaggtgtg ttgatagcta tattagtatt tcagcttgga atgttctata attaaaataa
    40081 atgtacataa aatatttaaa ataaaacaaa tctgtgctaa ttaaattttt atgatataat
    40141 gtagagtatt aaataaaaat aacttttaat tattgtatac aggaggagtt gttgtggata
    40201 acatagaatt gttaaggttg gcagaagatg ccagacaaca ttcttatgct ccttactcag
    40261 gttttagagt aggtgcagct cttttaacta agagtggtaa agtttatact ggatgtaata
    40321 tagaatgtgc atcattaggt ggaacaaatt gtgcagaaag aacagctatt tttaaagcaa
    40381 tatcagaggg tgataaggat atctataaaa tagctatagc aagtgataac tcagaaaata
    40441 atgagcaaac atatccatgt ggaatatgca ggcaggtaat tatagagttt ggttctgata
    40501 taaaaataat aacgggatat actaaaggag aggtgtttga gcatagtata aaggatttgt
    40561 tgccaaacta tttctctgga aatgatttaa aataaattta aaagtataaa taaatttaag
    40621 taattaaaac aagaagataa aaagttagga gacagttaat gttcaaatca ggttttgtca
    40681 gtatagtggg tagaccaaat gtaggaaaat ctactttaat gaataatgta gttggagaaa
    40741 aaatagctat aatgagtgat aagcctcaaa ctacaagaaa tacaatacaa gcagtatata
    40801 cagatgaaga aatgcagata gtattcttag atacaccagg tattcacaaa ccaaaaaata
    40861 aattaggtga atttatggta aaggcagcaa cagaagcttt taaaaatgta gatttaatat
    40921 tatttgtagt tgatgattct aaaaaaatag gtcctggaga tagaaagata atagaggatt
    40981 taagaagtgt taagacacca ataattttag ttgtaaacaa aatagaccaa ctagaccaaa
    41041 aagatgagct atttgatata atcaaaatgt atgatagaga aggtattttt aaagaaatag
    41101 taccaatatc agcattaaaa ggaaagaata cggatacctt aataaaagtt atacaaaatt
    41161 atttagaaga agggccaaag tattttccag attatatgat tacagaccag ccagaaagag
    41221 tattaatagc agaacttata agagaaaaag ttcttcacta tcttaatgat gaaatacctc
    41281 atggtgtagc tgttgaaatt gaaaaaatga aagcgagaaa tgataaggaa atagtagatg
    41341 tatctgctgt aatatactgt gaaagagatt cacataaggg aataataata ggaaaaaatg
    41401 gtaggaaact aaaaggaata ggtaagtcag caagacaaga tatagaattg cttttaggtt
    41461 cacaaataaa tcttcaatta tgggttaaag tcaaggaaaa ttggagaaat ttacaaaatt
    41521 atataaataa ttttggatat aatgataaat aaaggtgggt tatatggata ggaaactgga
    41581 tgcttcccaa gatttattat atgaagtaaa atcattaatt gataataata aagtattgga
    41641 gttaagagaa ttaatagagg aatatcatat aattgatata ttcgatataa tggaaaattt
    41701 agaggaagac atgaaaattc aattatttga agtacttcct ttagatatgg catcttctat
    41761 attagaagaa ggtagtgtag agttttttat tagtatttta tctaaactgg atgtagaaca
    41821 ctcgaaaaat atacttgaac ttatgtctct tggagatatg gcagacaagt tgagtgaact
    41881 tgaagaagaa gaaagagaac acataataaa tcttttgaat caagagaatg ccgattatgt
    41941 aaaagagtta ctattctatg atgaagattc tgctggtgga acaatgacca ctggatatat
    42001 ttctataaat aaagatatga cagctcttga ggctatagac catatgagag aagaagctga
    42061 agaagctgaa actatttatt atatatatgt ggttgatgat gaagaaaaac tagttggagt
    42121 attgtcatta agagaattaa taatagctag agacgcaaat atagtagaag atttgatgag
    42181 tgaaaatata atctctgttt atgtagatga agatagagaa gaagcagtaa gattagtatc
    42241 taaatacaat ttaatagcaa ttccagtagt agacagacaa gaaaaattaa aaggaataat
    42301 aacagtagat gatataattg atgtaatgga agaagaagca actgaagata tgtataaatt
    42361 tgcaggaagt tcagaacatg aaagagaagt tgcggaaaaa gaaaacccta cattgagaga
    42421 gcaaataata tcagcactta gaggacgatt accttggtta attattacct tagttggagg
    42481 gttgttggct tcgttaatac tttctaactt agactatata atgaatcctg tatatgctcc
    42541 attagtattt tttatacctg tagtaattgg tatgggtgga aatattggaa ctcaatcatc
    42601 atctgttaca gtaataacat tgtctaataa ggatttaaat tttagcaatg tggttagaga
    42661 aggtattgta ggtattatta caggtctttt gtgtagtata ataacaggta ttgtaattta
    42721 ctttgttatg agaaagttag acattgtatt aattgtttca atatcattat ttataaatat
    42781 ggttttaggt gcaacaatag gtgcgtttat gcctgtttta ttaaaaaaaa tggatgcaga
    42841 cccatctaca gtttcatcac caattatatc tacagctctt gatataactg gtatagcagt
    42901 ttactttata ataacaacgg cattattgtc aaaaattgtt taataacttt atgtatgatt
    42961 tatcctcttc ttactaaaaa tataagtata aatgtaagaa gggggttttt taaaaatgaa
    43021 caatatcagt tgggaagttt ttaaaaaaac aggtagtata gatgcatatt tatatttctg
    43081 tgattgcaaa aacatacatg aagaaattga agaagtaagg gagaaaaaag aagacgatga
    43141 taatcctgaa cacccagggg atagtactta aagctataag gtataaggaa agtgatataa
    43201 tacttacact atttacaaga aagcttggaa aagtatctgc aatagcaaaa ggagctaaaa
    43261 aaaataagag ctctttgctt tcatcatcac agttattttc ttatagcaat tttaccttaa
    43321 aaaaacaagg taatatgtac aaggttactc aaagtgaaat aataaaaagt ttttataata
    43381 tatcctatga tatagaggca ttttcttatg ctacatatat tacaaaatta gttgaaaatt
    43441 ctatacttga aaatcagact aataataggc tatttatatt acttgcgcag actctgtatt
    43501 tgtatacaca ggataataca gacaataggt ttataacagc agcattcgag ttaaaatttt
    43561 tagactatat aggatttaaa cctatagtaa ataaatgcat taattgtgaa tgtaaaattt
    43621 tacaaaattc tgtgtttaat atctacgaag gtggtatact atgtagtaag tgtagtaaac
    43681 tttttgataa taatataaaa ttagacttaa caactataag tcttatggaa tatgtattaa
    43741 gaaatgatat tttaacatgt agtaaagcta aagtatcaaa atatataaca catgaacttg
    43801 agaatattct agacaagtat ttgaaagttt atgttgataa tattaatttt aaatcattac
    43861 acgtattgca aagtgtaaaa aataataagg gagtggataa tgatgagtag taatataact
    43921 attgaaatgg ttgattcagt ctttgaaaga gttccaggag caacttatgc agaagcaaaa
    43981 gaagcattag taatgtgcaa tggagatgta attgaggcag taatatattt agaaaataaa
    44041 aaaaatactt gtaattgtaa agcaaaatct gctaaagaaa ctatggaaga agtatttggc
    44101 aaagatggag aaaatataaa gtttcaatta aaagagcttc ttagaaaaag tagtgtagtg
    44161 cgaataatag ttgaaaaaga tggaaaaact atgatgaaca ttcctttaac agttggagtt
    44221 gttggattag cttttgtacc attagctact ttagttggat tatcagctgc tgttataagt
    44281 aaatatcgta taaaagttca aaatgaagaa gatggagaaa ttgtagattt aggtgaattg
    44341 aatgaagaaa aacttcacgt tttgaagaat atgataacta atgcagcaaa agatgtgaag
    44401 gatgtagtag ttgacaaaaa agaagatgac aaagatgtaa ctgctgacct tatgaaagaa
    44461 gaatctgaaa agaataaaga agacgaagac gaaaataaat agatataaag tgacttttaa
    44521 aaaatgaaga gaagataatt ataagaatta tcactaacat tgacaaattt tatagaattt
    44581 gatattctaa aagttgtaga agaactatta aaatagcctt tcgtgtagac gagaggcttt
    44641 attgttatag gagggatttt tatgaatttt caagagatga tactggcgtt gcaaaaatac
    44701 tggtcaaagc aaggttgtat catgatgcag ccttatgata ttgaaaaagg tgcaggaact
    44761 atgaatccta atactttttt aagatcatta ggacctgagc cttggcaagt atgctatgta
    44821 gagccttcaa gaagaccagc agatggaaga tatggtgaaa acccaaacag actatatcaa
    44881 catcatcaat tccaagttat actaaaacct tctccagata atatacaaga attatatttg
    44941 gaaagtttaa aagagattgg aattgaccca agtgagcatg acataagatt tgttgaagat
    45001 aactgggaag ctgctacagt tggtgcttgg ggacttggat gggaagtttg gctagatggt
    45061 atggaaataa ctcaatttac gtattttcaa caagtaggta atattgaatg tgagcttgag
    45121 acaggagaaa ttacatatgg attagaaaga ttagctatgt acattcaaga agttgatagt
    45181 gtttatgatt taaaatggaa tgataaaata acttatggtg aagtatttaa taaagctgag
    45241 tatgaaaact caatgtacgc atttgaatta tgtgatgcag atatgttgtt taatctgttt
    45301 gatatatatg aaaaagaagc attaagactt atggaaaatg gccttgtaat accttcatat
    45361 gactatgtgt taaaatgctc tcatgcattt aatacattgg atgcaagagg tgcaatagga
    45421 gttagtcaaa gagcttcatt tataggtaga gttagaaata tggcaaagac tgttgcagaa
    45481 acttttgtaa aacaaagaga agaaatggga ttccctcttt taaaggacgg tgacaaataa
    45541 tgaaaaatta tcttttattt gaaatcggtg ttgaagaaat gccatcaaga tttgtaggca
    45601 gtacactaga acaattaaaa aacaatctta gtaaattatt tgatgaaaat agaatagctt
    45661 ttgataaaat aaatgcgtat gggacaccaa gaagacttac tttagtagtc gaaggattga
    45721 gtgatagaca aaatgattta gaagaggaaa taaagggtcc tgctaagaaa attgctgttg
    45781 atgcagaaaa taatttaaca aaaccagcat taggatttat aaaaagcaaa ggattaagcg
    45841 aatctgacat atattttaaa caagttggaa aagaagaata tatatttgcg actataaagc
    45901 aagatggaaa agaaacttca gaagtactaa aagacatatt accagagact ataaaatctg
    45961 tagtattccc aaaagctatg cgttggggag gaaaaaatct taaatttgca agacctataa
    46021 gatggatagt tgcattgtta aatgataaag tattagagtt tgatttagaa ggaataatat
    46081 cttctaatgt aacaaaaggt catagatttt taggtgaaag tacaatagaa gttgattcta
    46141 tagaagatta ttttgaaaaa ttagaaaaaa attatatagt tttagaccaa aacaagagaa
    46201 aagaaatgat aagaaaacaa tgtatagaag tggcaaattc tttaggtgga gaagttgaat
    46261 ttgatgaaga tttacttgaa gaggtaactt acttagttga atatccaact gctttttatg
    46321 gagaatttga tgtggattat ataaaactac caaaagaagt tgttataact cctatgaaac
    46381 aacatcaaag atattttcca gtacttaaag aaggaaaact gttacctaac tttatagctg
    46441 ttagaaatgg tgattcttac agaatagaca atgttaaagc tggaaatgaa aaagttttag
    46501 aagcaagact tgcagatgct ttatttttct atagagaaga tactaagaga aacttagaaa
    46561 gctacataga aaaattaaaa actgttgtat tccaagtaaa actaggaact atttacgaca
    46621 aaactttaag acttgaaaaa ttaagtgctg atatacttga tagtttaggt ttagtagatg
    46681 aaaaggcaga tactataagg gctgctaaat tatctaaggc agatttagtt actggaatgg
    46741 taggagaatt tgatgaatta caaggtttta tgggaaaaga atacgcaaaa gttggaggag
    46801 aaaatgatgt tgtaagtgaa gctatttttg aacattatct tccaagattt gcaggagata
    46861 tacttcctaa gactaatgca ggagttgcct tatcaatagc tgataagttg gattcaatag
    46921 caggtttctt tgctatagga atacaaccaa caggttctca agacccatat gctttaagaa
    46981 gacaagcttt aggtatactt agtatactta tggacagaaa agttgctgtg gatataaaag
    47041 tacttattga acatgcttta gacaattatt ctgaattaga ttttaataaa gaagaagttg
    47101 ttgagcaaat aatgaatttc ttcaatgaga gagtaaaaaa tctatttaaa gatttaggaa
    47161 taagatatga tgttgttgat gctgttttaa gttctgatat aaatgatgtt tctgatatgc
    47221 atatgagagc tttagagctt aataattggc tagaaaaaga tgaattagtg gagatgctta
    47281 ctgcatttaa tagagtttct actctagctc aaaaagcaga aagtgataaa attgatgaat
    47341 ctttattaaa agaagatgct gaaattaaac tttacaatga atttaaacaa gtaaaggtaa
    47401 aagttaatga attattaaag gataagaaat atggtattgc tttagatgaa tttgcatctt
    47461 taagaccagt agttgataat ttatttgata cagttatggt tatggataat gatgaagcta
    47521 ttaagaacaa tagacttgct ttacttaaac aagtatatga tactatgcta ggaatttgtg
    47581 atttatctaa aattgtttat aaataaaatt taaactattt ataagaaata aggctgtctc
    47641 aaaatagaga tagtcttatt tttcattgtt gagatgatga aaatatattt gatttcatag
    47701 aaaaagagtg tctcataaac taaaaagttc attttgagac acccatgctt tttgtaagta
    47761 aatataataa attatatttt atacttatca gttattttgt ttaaaatatt atcatttgaa
    47821 tttacccatt cataaaaatt gcctgatgat gcgtccgata ttttataaag catttcagga
    47881 atatcactag ctttaaaatc tccaagtgat tttcccaatc tagtcttacc tatttcaaaa
    47941 ctgcctccaa caaataattc aaatgcatct gtagatatac catcaacatt cttcttttta
    48001 ccacataaac ctatgctacc aacttgatga acaccacatg aatttaaaca tcctgatata
    48061 tataacttag gtgctttatt taaaatttct ttattatttt gtaatctaaa ataatctatg
    48121 atttcatgta acattttctg actattttgt atgcccattt gacaaattgg aacacctatg
    48181 caagatatac tttgttctaa ttgagaatta caactaatag ttttacttat ttctaatatt
    48241 ctttttgctt catttccatt taaatttaaa atatataatc cctctgtcat tcctagtcta
    48301 atcataggat tttcaatatt atctaattct ttaagtaaag tacttaaatc ctttgttaac
    48361 aaaatacctc caactggatg tatatataca gtgtataaac catcctgttt ttgaggtatt
    48421 agtctagaat cctgtatatc tattttaacc ccaggtttag agtaatctat ttcttcaata
    48481 ttgagttcaa gactaccatt ttctttttct aatttatagt attctttaaa tttttctaag
    48541 aataattttt caccaagtga ttcgaccata tatctaaccc tagctctgtt tttattttca
    48601 taatttccat aatccataaa gaatttaatc ataccttcaa cacaatataa ggcatctttc
    48661 ggttttataa gttcatcaag ttctaaagca actttgggtt gtttacctag acctccacct
    48721 aagaaaactc tgaaatatgg ttcatcattt ttcaaagtag caacaaatcc taagtcttgt
    48781 atactacaat gagcagtatc tgtgtaacaa ttagaataag aaacttttaa ttttctaggt
    48841 aaatggtatg tagtagcatt tttgataaaa tatttatcag tagcaactgc atatggagta
    48901 acatcaaaga cttcactagg gtcaactcca gataatggag ataatccgac atttctagga
    48961 taattaccac caccacctct agtgaatata tcatttttta ttccttcttc catgatatca
    49021 acaattgaat ttatagataa atcgtgtaat tgtatagctt gtctagttgt taagtgtatc
    49081 ttatctaagt tgtgtttaat agctatttca tagattttat taagttgata ctgagataaa
    49141 actccagcag atactctaag tcttatcata aaagattttt tgtctctttg agcataaaca
    49201 ccatatccac cagaaaatcc cttatattgc attttattta tttctccatt taaaaatttt
    49261 gaagaatatt ctttaaaatt aggtagttca tttaacaata tctttttaaa attatccatt
    49321 atttcacctc attgttagtc ttgtataaaa atatatctat tgtataatag atatatatat
    49381 tattatctag tcaggataaa aatataacag aataattcta ttaaaagtaa gaataataag
    49441 gacatagtga gtattttgtt tttattttac aaattaagta taatattttt gttttataaa
    49501 atataattaa gataaataga taattttgta attttaatat ataatattta gtagagtgtg
    49561 ggagtagcac ttaatatttg aaggaggagt ttttgtatat gggagaaata ataaatgcat
    49621 tagatagagc cctagacata attttgctgt tatatcatga aaagagagaa atgggaataa
    49681 ctgaaataag caaggctatg ggagtatata aaagtactgt acatagaact ttggttactc
    49741 ttgaaaacaa aggttttgtt atacaaaatg cagagaatgg taagtattgg ctaggaataa
    49801 atttatatgc aataggtatg gttgtgggag aaaaaatgtc attgactgaa atagtaaaac
    49861 catatacgaa aaaattaaat caagaattta acgaagtagt taatgtatct atattagaag
    49921 aaagagctca agattctcca agaagtatca taatacataa agagtatggt tcaaatcaat
    49981 tactttcagt aaatccatcc gttggttcaa gtagtgaatg ttattgttca gcagttggta
    50041 aatgtcttat ggcatttaat gattctatag attttgaaaa atatagaaaa acaccaatac
    50101 acaagtatac agaacataca attgataatt gggatgatat gatgcttttt ttagcaaaaa
    50161 taaaagaaca aggatatgct atagatgatg aagaactaga acatggacta acttgtattg
    50221 gagcacctat cttagataaa aataataaag ctattgcagc cataagtttg tcaggtccaa
    50281 ctataagaat gagagaaggg gactttgagt ataagattaa aagagttata gaaactgcaa
    50341 aaagtatatc tgaacttttt agatgatttt taatctcgat aataaaaata ggctatattt
    50401 aaattgttat ttgtaaatat cagtttaaat gtagcctatt tttctttaat ctaaaattaa
    50461 atattcttaa aatttaaaat gttattgaaa tatataagcg aatgtgttat cttttaatta
    50521 agcaataaaa atagaacaag gttctatact atagaacaaa attgatgcat atatagtatt
    50581 tatacaaaat ataaatatta tatatttaaa attaagtaaa aatattacat aaaggggaga
    50641 tttgagaaat ggaaaaagtc aagttgagtg ttgaaagatg taagggatgc tatctttgta
    50701 ttgaagcttg taaaaaagat gcaataagtc tttctgacta cacaaataaa aaaggctttg
    50761 taactattaa agtcgatgaa gaaaaatgta ttcaatgtgg cgcttgttat acaatgtgcc
    50821 ctgatttagt atttgagata ttataaatta tttttattag aggggagaaa aggtatgcaa
    50881 agtttattaa ttaaaggaaa tgaagcttta gcagaaggtg ctatacgtgg tggctgcaga
    50941 ttttatgcag gttatccaat aacgccacaa tcagaaatat tagaaatgat ggcatggaga
    51001 caaaaagaag ttggaggagt atttatccaa ggtgaatcag aaatagccag tgtaaatatg
    51061 gttatgggag caagtgcact tggagcaaga gctatgactt cttcatctgg tccaggattt
    51121 tcattaaaac aagaaggtat tgcatattgg gtatcagctg gtttgccagc agttgtagca
    51181 tgtgtgcaaa gatatggtat aggtgatgga tttataggag ctggtcaaga taattattgg
    51241 caagcagtaa aaggcggtgg aaatggagat tatcatttaa tcgtgttagc acctaatagt
    51301 gttcaagaaa atatggatat ggcatatgaa tcttttgaat tggctgaaaa atatatgcat
    51361 ccagtactta tactttctga tgctacaata ggtcaaatgg tagaaccttg tatagcacca
    51421 ccaatgaaag aatacgatat ggataaagct ccatgggctg caaaaggaac acctgtagga
    51481 gaaaaaaata aagtaataac tgatataaca tattttgaag accaagatac atggcaaaaa
    51541 gggtatatag aaaaaatgag aaaagttcaa gaagatgaac aaagatggga agagatagaa
    51601 atagaagatg ctgaagtggt atttgtggca tacggtattt catcaagaat agcagaaggt
    51661 gcagttagag atgctagagc aaaaggaatg aaattaggtc taataagacc aaaaacattg
    51721 tggccttacc caagaaaagc atttaagaaa ttaagtgatt cattgaaggg acttgtaaca
    51781 gttgaaatga acatgatggc acagatgaag gaagatgtaa ttatagcatg tgataataga
    51841 tttccagtat attcagtagc aacagctcaa tatatggcag aagtaaatca attaatagat
    51901 tttgctcaac agattataga tggaaaagct aagcaagagg aggtatttta attatggcta
    51961 aaaaagcacc agcaataatg atgtgtgaaa atatgttctg tggaggctgt ggacactcta
    52021 tagtcgatag aattattgga gaagtattaa cagaaatgga tatatgtcaa gatacaatta
    52081 tatgttcaga tataggttgt aatcatatgt ttcaatttag tatgaatgta gatgttgtcg
    52141 ttccacctca tggtaaaatg ggagcagcaa tggcagctat gaaaagagtt agaccagata
    52201 aatatatatt tacaatagct ggagatggtg gagcttatgc aatagggctt ggagaaacta
    52261 tgtcagctgc tactagaaat gataatgtaa tatttcttgt tatgaacaat aatatgtttg
    52321 caatgacagg agggcaaatg gctccaacta ctatagaagg tcaatataca gcttctactc
    52381 cagcgggtag aaattacgca gatcatggtt caacatttga tgttgtaaaa gttatgggaa
    52441 atttagatat agcatatcta gcaagaggaa caataactaa ccctaaagaa ataaatacaa
    52501 caaaaagata catcaaaaaa gctctagaaa aacaaaaaga aaagaaaggt ttttgcttaa
    52561 tagaagtgct tgtaccatgt ccaacaaact ggggattaaa gccagtagat gctatgaaga
    52621 gaattgaaaa tgaacttgtt ccaaagtatc cacttggaga atttattgat tagggaggaa
    52681 ataatatgtt gaatgaaatt atatgtgctg gttttggagg acagggagtt cttacagcag
    52741 gaaaaattat aatgtatgtt gcatataagg cagaaaagaa aattacatgg ttcccatctt
    52801 atggaaatga gatgagggga ggaagtgcaa attgcaatgt tgttgtaagt gatgaaaaaa
    52861 ttgcaaatcc ttgtgtaaaa aatccagata tactattggg aatgaacagc gtatcagtag
    52921 ataagtatga aagtttaatg aaaaaaaatg gttatatgtt tgtcaatgaa tcactagtaa
    52981 gtaaggatag aaagtacaga gaagacatta atgttataaa agtacctgtt actgaaatag
    53041 cacaaaattt aggcaatgaa aaagctgcta acatttgcat gttaggtgct atggtaaaga
    53101 gtttggattt atttacaaaa gaagaatttg aaagtggtat gtgtgaatac tttgaaaatc
    53161 aaggcaaagg taaattcaat tctaaaaatg tagaagcatt tgaagctgga tacgactacg
    53221 aatgaatatt ttaaatattt aaaataatta ttgaaatact tatttttata tgttagtatt
    53281 taattaataa aatatagaac gtcgttctgg acaatgggac gaagtcttta ggtcggaata
    53341 caagaacggc gttctgtata atagaactag ggggtgttaa attgaaagtt ttagtaataa
    53401 atcctggtgg tacatccaca aaaatttctg ttttccaaga tgaaaatgaa attttgaaaa
    53461 aaaatataac ccatacaaga gaagatttaa aaaatttttc taaagtattt gatgaatatg
    53521 attatagaaa acaactgata gtagatattt taagtagtga gaatcatagt ataaattctt
    53581 ttgacgcagt agttggtcgt ggtggactta tgaaggctat aaaaggtggt acctatactg
    53641 tgagtgaaga aatgattgag gatatgagaa atgaaataaa tggggaacat gcatcaaatt
    53701 taggtgcatt attagctaaa actatagctg atgaaatagg agtacaatca tttgtagtag
    53761 acccagtttc tgtagatgaa tttgatgatg tatcgaggat tacaggaata tcagacatag
    53821 aaaaagcaag ttggttacat gcattaaacc ataaagctgt ttcaagaaaa attgcacaaa
    53881 aactaggggg aaaatacgag gattataact ttattgtagc tcatttaggt tcaggaatat
    53941 cgattgtagc acataaacaa ggcaaaatga ttgatggaag tggtggtagg tctgatggtc
    54001 cattttctcc agaaaggagt ggtggattac ttgcatatcc tcttatagaa ttgtgttact
    54061 ccggaaaata tactcatgat gaaatggtcg caaaagtaag ttcgattggg ggaatgtacg
    54121 attatttagg aacaaaggac atgatagaaa ttgaaaacag aatcaaggag ggtgatgaaa
    54181 aggcaaaact tataatggat gcatttattt atcaagtagc aaaagaaatt tctatgtatg
    54241 gagcttcact ttcagggaat gtagatagag ttatcttgac aggagggata tctcactcag
    54301 aaatggtagt caaaggagta gcagaaaaag tttcatatct agctccaata gagatagtac
    54361 caggagagat ggaaatggag gcacttgctc taggggcact tagagtactt aatggagaag
    54421 aaatagcaaa aacttattaa tatttaggag aaagagtatg ttaaaagatt ttaataattt
    54481 attagaagag gctaaaaagc ttgaacctgt tattgtaagt gttgctgttg cagaagacaa
    54541 agaagtatta aaggctgtga aatcagcaac agatttaaac attataaagc caattcttgt
    54601 aggagacaag gataaaatag aaagtatatc aagagaaatt ggattaaaag gtcatgaaat
    54661 aataggttgt caaaatcccg atgaatcagt taaaaaagct gtagagatag ttaaaaataa
    54721 ggaagctaaa gttcttatga agggattagt aaatacaagt gtctatatga gagctatatt
    54781 aaataaagaa acgggtctta gaacaggaag attattaagt ttgcttgcag tatatgaatt
    54841 acctcaatat cataaacttc tttattgtac tgatagtgga ataaatgtat cgccaaactt
    54901 aaatcaaaaa aaagatataa tgacaaatgc acttcttact atgaaaagta taggcatgga
    54961 aaatcctaaa actgcgatac ttactgcaaa tgaaatggta gaccctaaga tacaatctac
    55021 agtggatgcc aacctacttg tagagatgga aaaatcggga gaaataccaa agtgtatagt
    55081 ggaaggtcca atagcatttg atgtagcatt tgatgcacat gcagcagaac ataaaggtat
    55141 taaaagtaat attgctggtg atgttgattt attagtattt ccaaatatag aagcagggaa
    55201 tatattagga aagtcatggc ttagatttaa taaagctaag tgggcaggta tagttttagg
    55261 agcaacaaat ccgataattt taggttcacg ttctgacaca gctgaaataa aaataaattc
    55321 aatagcatta gcgtgcctag catcacaata agaaattatt attaaggagg aaaaagtatt
    55381 atgaaatatg caaaaagaat ggatatggta aaagcttcag ctataagaga ttctcaaaag
    55441 aaaatagctc agaaggtagc aagtggtgga actgttatat cttttgctgc agggcttcct
    55501 gacccaaatt tatttccaat agaagagata agtgaaataa ctcaaaaagt acttaatgaa
    55561 aggggaaaat ttgccctagc atatggacct actaaaggtg aagatgagtt gttagatcta
    55621 ttagtaaaaa gaatgaaaga agaagaaaat attgatacaa aagcagaaaa tattataata
    55681 actactgggt cacaacaagg gatagcatta agtgctatga ttttattaga aaagggagat
    55741 gtagtagtta cagaaaatcc aagttactta ggtgcaataa atgcatttag accttatgaa
    55801 tgtgattttt taggagtaga tacagatgaa gaaggaatgg taacagatga tttagacaaa
    55861 ttattatctg aaaattctaa cataaaggtg atatatgtaa taccaacatt tcaaaaccct
    55921 acaggaaaaa catggtcttt acaaagaaga aaagatttta tggaagtcgt gaataaatat
    55981 gatgtcatag taatagagga taatccttat ggagaaataa gatttacacc agaacctcta
    56041 cctacactta aatctcttga tactaaagat aaagtattgt accttgggtc attttcaaag
    56101 gtattatgtc caggatttag agttgcttgg atgtgtggta atgtagacat catagataag
    56161 gcagaacttt taaaacaagg tatagattta cagtcaaatc aattttcgca agtacaagta
    56221 atagaatttt taaagaaata caacttaaat gaacatatag aaaaaataag agcagagtat
    56281 aagaaaagat gtctgctaat gttagatgct atgaagaaac atttcccaga ggaagctaaa
    56341 tatacagaac cagatggagg aatgtttata tgggttgaac ttcctgaaag tataaatgta
    56401 gatgatttat tagataaagc cattgatgct ggagttgctt atgtttctgg agagtccttc
    56461 tttgcaaata atggtccaaa aaatactatg agacttaact atacaacaat gtcagaagaa
    56521 caaatcgtta aaggtgttga gatacttgca gaagttataa aaaaagaact caattatgct
    56581 tgtgaataaa tataaaaagt gagggtttaa atatgggaga aaaagaaaac ggtataaagt
    56641 ttggaaagtt aatgtttcaa cttgttatta tagcaatatc ttgggaatta gtttatatta
    56701 taccatttat ccaatataca ttatatgatc caatcctaaa agcattagaa tgtacaaaca
    56761 ctcaactagg ttttctactt acaatttatg ggttaggtaa tatatttgga gctcctatag
    56821 gaggctggtt agcagataga tttgattata gaaagataat tttaggttct gtatttctta
    56881 atggagtagt atcattttta tttgcattta atatgaacta tccatttgca gttgctactt
    56941 gggtaggttg tgcaatcaca tcattagtta tgaactatcc ttctatggta aaaatactta
    57001 gagttatagg aaaagataat caaggtaagg tttatggatt taatgaagct atggttggag
    57061 tttctggagt agtaatggga gcaatattct tatatattta tacatgcttt gcaactccta
    57121 cattgggtat gagatgggta atgatatctt taggaatatt atcaatagca atgtgtccag
    57181 tattatggtt tgtaattaaa gatgtagata ttaaagaaga aagagaagaa gcaggtgaaa
    57241 aaatgtctgc tggtgatttt ataacagtac taaaatcacc aaatacttgg ctagtaggaa
    57301 taagtatatt ctgtgtatat tcattcacag ttacaatgtc ttattttaca ccatatataa
    57361 catctgtact tggaggttct gtagcattat ctggtgcatt agcaataata agacagcatg
    57421 gtctaaaatt atttggagca ccatttggag gatattgtgc agacaaatta aaatctccta
    57481 caaaagtact tttaccaata tatgtatttg gtatagcagt aatagtttta ttcctagtat
    57541 tacctgcatc aactccaatg actatattca tagctttaac atttgtagta ggtatattag
    57601 gttacatggg aaaaggtata tattatgcag tacaagatga agtaaaagtt ccagttaaat
    57661 attcagcaac tactataggt atagctgcag ctttaggatt ttcaccagat gtattccaat
    57721 ttgcattaat aggacactgg atagatactt atggcaataa aggttacaca tatacattta
    57781 tattccaaat agcaattcta gttattggaa tactatcttg tttatatata ttaaaggtta
    57841 aaaagagaag agcaagtaaa ttagaagctt aaatattcaa tttggtaatt aagtatatat
    57901 aaatacaata cttattttga tgaatgtgat tgtataaata acataaaaaa tatcaataga
    57961 ttaagtttta taataatgtt tagagaataa agtataaaaa tcaaaatgtt atcaagtttt
    58021 ctaggtttta acataaagtt acccctgaag gtgtaaaatt gagtggcaat tattatctat
    58081 tttcttacct acataaacct atttaattta aattctaaga gattttcaaa atagatggta
    58141 gttgtactca attttaaacc tcataataaa tacgaaaatt taaaatctaa ctagatacta
    58201 tttaattata ta
//
LOCUS       DAEHWM010000013        57055 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.014, whole genome shotgun sequence.
ACCESSION   DAEHWM010000013 DAEHWM010000000
VERSION     DAEHWM010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 57055)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 57055)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..57055
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.014"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(223..1062)
                     /locus_tag="KNP36_000846"
     CDS             complement(223..1062)
                     /locus_tag="KNP36_000846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBF0872735.1"
                     /translation="MSDIKNEVSKKTLSKKDVIKSWLRWFFFAQSNYNYERLQSTAFS
                     HSMLPVLKKLYPDKEELKQEVETHLAFFNTEPICGCVIHGITIAMEEEKANGADEISG
                     DGMNAIKTGLMGPLAGIGDTLTQGVITPIVLAVCIGLTEGGASIAGPILFVIAQYIIM
                     TSISFGMWTNGYKYGKKAVESILQGGIVNKVIEGASILGTLVMGGLVGRFINLSTPIS
                     YTSGDFKFSLQTDLLDKIFPGLIPLVLTLLVLFALKKGLSPIKIMFILIVVGAITGIL
                     GLF"
     gene            complement(1086..1844)
                     /locus_tag="KNP36_000847"
     CDS             complement(1086..1844)
                     /locus_tag="KNP36_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872736.1"
                     /translation="MHISLIQAVLIAIFYYLSWSPWLTYVGFFTWNRPLLAGFVTGII
                     LGDPVQGAIIGAGINMIYLGFISAGGAQMGDPAFAGYVGTALAIASKLDVSTAMAIAV
                     PLGTVATVLWIGKMTVNSFFAHWADREVQKGNVDRVAFINIVPPQILLFAMSFIPALL
                     VVYFGPNAIDGMLEVMNDNVLHVFNVIGAMLPALGIAMNLKLIGNKFTMPFFILGILM
                     AVYFKVDIIVISVIGVILALTITSIKYGKDSATS"
     gene            complement(1891..2364)
                     /locus_tag="KNP36_000848"
     CDS             complement(1891..2364)
                     /locus_tag="KNP36_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872737.1"
                     /translation="MSNIALTRIDDRLIHGQVITAWCKITSAKRIVIVDDLVVKDPFI
                     VQVLQMAAPSTVKVEVHDVESGAEVLKSHNGDENLIVLVKYPKTVLGLVNSGVDLKEL
                     NVGGMGAGLGRKSFYKNISVSDEEKEIFRELISKDVKCFIQIVPDAKKIDVGTLL"
     gene            complement(2393..2809)
                     /locus_tag="KNP36_000849"
     CDS             complement(2393..2809)
                     /locus_tag="KNP36_000849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0872738.1"
                     /translation="MIHMAGIIIATHGNMAKAMLESAELIVGKQENVETLGLNHGDSI
                     DEFSRKLEDGIEKYKDEGVLVLLDFYGGTPFNTSAIVINKFAKVCELECLTGVNLPML
                     LELFLNRDTMKLKDLKNLCEEVGISGIKDVKTVLKL"
     gene            complement(2856..3908)
                     /locus_tag="KNP36_000850"
     CDS             complement(2856..3908)
                     /locus_tag="KNP36_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBF0872739.1"
                     /translation="MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISK
                     YSKTGPHMVGEILGHEFSGEVAQVGKEVRSFKIGDRVAVCPAMPCFECDECKKGLYSR
                     CNNVAIIGNKELGGCFAEYTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAK
                     VGDTVVVLGTGPIGLFSIQWAKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNI
                     VEEIKRLTDGDGADIVIESAGTPLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEK
                     IVRSELTVKGTWFGNSFPFPGKEWSAGLYHMQKGDMNVEKLVTHRINLEEVPAYFEKV
                     YKRDIFFGKIMINIDN"
     gene            4304..4984
                     /locus_tag="KNP36_000851"
     CDS             4304..4984
                     /locus_tag="KNP36_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HBF0872740.1"
                     /translation="MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGENSVGL
                     SIDGIGRANLETSVKFFEILNNAGIKTHYVSANLEEATMEVLPAKVFGNGLEVICRYR
                     AVGSFLRRYGSCVEEGAKLDCYVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKS
                     MTQKISNIVRDTIAEKGLELYDIKFEFGFYNDEVILIDEIASGNMRVYKDGVIVDPMD
                     LTALLLDK"
     gene            complement(5117..5437)
                     /gene="sugE"
                     /locus_tag="KNP36_000852"
     CDS             complement(5117..5437)
                     /gene="sugE"
                     /locus_tag="KNP36_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000118520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quaternary ammonium compound efflux SMR
                     transporter SugE"
                     /protein_id="HBF0872741.1"
                     /translation="MKWLFLFVAGLFEVFWAFQLKNSHGFSKLTPSILTVVGMIVSFY
                     FLSLALKHLPLGTSYAIWTGIGTVGTAIVGMAILNEPISISRIACIGFIVVGIVGLKL
                     LSTN"
     gene            5819..6646
                     /locus_tag="KNP36_000853"
     CDS             5819..6646
                     /locus_tag="KNP36_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="HBF0872742.1"
                     /translation="MNFYKIAVCQMITTENKIENINHAVDMVTEAAINGAKIVVLPEM
                     FNCPYENKYFPKFAEEYPGETTTILSKLAEKHGIYLVSGSIPELEDGKIYNTCYVFDK
                     NGALIGKHRKMHLFDIEVTGKVSFKESDTLTAGNDVTVIDTEYGKVGIAICYDIRFPE
                     LSRLMALKGAEIVILPAAFNMTTGPAHWELSIRMRALDNQIFYVGAAPARNMNASYIA
                     FGNSRISDPWGRIIAQADEKECIIYADIDRDLIPDIRQQLPLLKHRRTDLYELNTLK"
     gene            7468..8142
                     /locus_tag="KNP36_000854"
     CDS             7468..8142
                     /locus_tag="KNP36_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872743.1"
                     /translation="MNNKILVVDDEEGIITLLKDYFEMNGYEVYTAQSGKDALKKISK
                     NPDIILLDINMPEIDGIEVCNRIRDYVSCPILFLTARIENTDKINGFRAGADDYIVKP
                     FDLDELGARVSAHLRREQRKSNQTKIKFYNDLTIDYEKRLICIYNNQISLSKKEFDIV
                     ELLSMNPGQVFDKEKIYDRVWGYNSNGNSDVIMEHIRKIRIKLSKHTLENYIETVWGV
                     GYKWIK"
     gene            8130..9290
                     /locus_tag="KNP36_000855"
     CDS             8130..9290
                     /locus_tag="KNP36_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0872744.1"
                     /translation="MDKINNMSLKKAFFVLTLSSLIIASVLTTFAYILLNNLYNSIQD
                     KYLKTPINTGIITIVQNNVNQFSDYDKTLLNIINILQLVLPLIFFIGLLLLADIIFYK
                     VKLKTPIEILNKGAMEISNNNLDFCLEYNNNDELGNLCNAFEKMRSELNKNNIKMWTM
                     INDRKQLNAAFSHDLRNPLTVLKGYSNYLTKYIPTGKLSDEKILSTTQLMSEHINRIE
                     YYVENMSNAQRLEDLVVSKSMSNINKFIENLDENISIIAKQEGKSFTLKSQINNINLF
                     FDENIILRVVENIISNAFRYARNNVSILIYLEQELLTFVIEDDGIGFSKESLKLALRP
                     FYRDKTLNDSNAHFGMGLYISKILCEKHGGSISIENNSTNSAKITAKFSTRN"
     gene            9506..10033
                     /locus_tag="KNP36_000856"
     CDS             9506..10033
                     /locus_tag="KNP36_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014118918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="HBF0872745.1"
                     /translation="MKSFANNITFSRIVFALLMLSSTFSSLPFWICYFWCGISDILDG
                     LIARKLRQQSGIGAKLDSIADFIFAVTILVTVGKNIALPMYLWWCIVAIALLRLISYS
                     IGFFKYRTFSSLHTLMNKITGISIFAFPLLYICFGLDVAGIMICIVAFLSSFEEIAIM
                     IKSKELNRDIKSIFM"
     gene            10319..10987
                     /locus_tag="KNP36_000857"
     CDS             10319..10987
                     /locus_tag="KNP36_000857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872746.1"
                     /translation="MIIKAKQLSKIYGSNNNKVIALNNVNLEINSGEFVSVIGPSGSG
                     KSTLLHILSGLDNPTSGQVLLDDKDIYKHTEKELSALRRKSFGFVFQQFNLLPVLTAS
                     ENISMPVLLDKKQPDKDYLNEISSLLGIADRLNHLPHELSGGQQQRVAIARALIAKPD
                     IIFADEPTGNLDSKSGSEVMNLLIKTSKQFGKTLVVITHDDRIAKLADRKISIIDGVL
                     MEVK"
     gene            10990..13458
                     /locus_tag="KNP36_000858"
     CDS             10990..13458
                     /locus_tag="KNP36_000858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872747.1"
                     /translation="MKNYLSLSIKELKSQKFMTTFIIIAIVLSTIMTTVVGQSIGILQ
                     NLRIEQARSFNGDRHVSFHQLTKNQVDDIKKDDRVYQAGTSITIGSSKIKDSGISVLV
                     KEYDKTGLSNYPKLMKLKSGHLPKDKNEIALDENTLKLMGIKPRLGVTIPMNLDISLL
                     NDTIPPYNYTANFKLSGILEDDYTGYVSGIVNGIVGKGTSENLLPKRYILSSLDFKIK
                     QQEKFQEIVNQLAKKINLSHNSIQYNWIYLNALKIQFEKDENSSNSDGISMIILVSLF
                     VALLVLLASGLVIYNILKISVTKKIKEYGCLRAIGAEPNQIYKIVILQILILCTVAIP
                     IGAVIGIISSKGITGMVTNILNPDILLANDNKEITELIHKNTTAYIFPLVLSTNVSLI
                     FSFISALPSAIYASHVSPKIAMVGSTTKIKRKIKREKTIKNFERHLAWLNLKRNKGRT
                     IITILSLFMSITVFVALSEFSNVLDVSRSVSNLKEGDFSLTNEISGFDKSTLDKIAKM
                     KNVNRTSFIKYSEYKQGEIDTDINFENSGEMLKIIGIDEQTLKDLMPSITDSILEDFK
                     NGSICFIKNPIAISTPGVKTRYTNLKPKDSITINKKQLDIYSTVDKMFFLQGNGWING
                     VDVIVYDSVYNTLTNKNKFNQINIYAKDKSKLEQIRLSIEQICENNPGSHWISYIESD
                     KQLKESFKQIEFLAWAVILFVGLIGTLNIINTTHTNINTRTNEIGVKRAIGMSNRSLY
                     KMFLWEGVYYGIFAAIFGSIAGYASAIIINMATIEKLDFTNIPITSILQATIISVLAC
                     IIATLIPLRKVKKMNIIDCIDINL"
     gene            complement(13698..15122)
                     /locus_tag="KNP36_000859"
     CDS             complement(13698..15122)
                     /locus_tag="KNP36_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872748.1"
                     /translation="MKNQSLITQFRHTFIFIIIASIVATVITYVFALYLYIHSLNKDI
                     YPPNYYERQVPRIEKYINEKNIALLSQSNEEGLKRTIRGDDMLYQVVDNNGNILYGTN
                     PKKLFKTKEELFNNFINKTVRKGGYIHTVPIKGDNGKIEGAVILFYQVKITFANIRGR
                     FVFAVIIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYY
                     SDNELGKLCSAFSEMKDELKGSLSAQWKMEQERVEMVEALAHDLKSPLSIILGYTDAL
                     IGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQ
                     KVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGGNISI
                     TVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVE
                     QLGGSVKIENSKSGGACVKFWHSI"
     gene            complement(15141..15833)
                     /locus_tag="KNP36_000860"
     CDS             complement(15141..15833)
                     /locus_tag="KNP36_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872749.1"
                     /translation="MSKILIIDDEMDLVMLLEDELKAKGHEVLIAYDGQAGIELSKQE
                     PDLIILDIMMPKMNGFEVCQAIRDDVLCPIIFLSAKQSETDKIKGLTFGGDDYVTKPF
                     GLRELMARIEANLRREKRSQYINEENKRSTLYFGKLCLYMKERAIKIDGKNIDLTKIE
                     YDIVELLALHAGQVFSREQIYEKVWGCDSEGDSSTVVERVKKIRAKFSAVTPEKEYIS
                     TVWGIGYKWNKM"
     gene            complement(15885..16664)
                     /locus_tag="KNP36_000861"
     CDS             complement(15885..16664)
                     /locus_tag="KNP36_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HBF0872750.1"
                     /translation="MIKLLSSEWLRAKRTAVQWLTLCMPIIFSLCVVFYLTTKSGSTQ
                     EFAFEGFFTVWTVFIIPIGVGILAGFIVQEEELAGNFNGFLCVGISRVRLYLGKFLFL
                     LFCLTICTFIATLILCIGMSIAVPSGATIWLFLSAAGLVVIGTLPLLAIHLWVSFAWG
                     MGASIGISIGGILMAAILGLTSVGEKVWAFVPWTWPVKLGMLPGIYFIKEAGTISTEA
                     FYSKVMQTASIELIVVAIGLIIFLIGGVIWFKMWEGRKSYE"
     gene            complement(16661..17431)
                     /locus_tag="KNP36_000862"
     CDS             complement(16661..17431)
                     /locus_tag="KNP36_000862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="HBF0872751.1"
                     /translation="MNALQSELLKYKRTFMGKLIVFFPVSFAAYAFIMQSTLMQNPLS
                     QTTSWAWQNLLALIFNWWSFLFLPIGFALFATLVAFQEKKAGNYRALRTHNVSPMTLW
                     INKVIAMAVYSFISTLVLIVVTIITGLILKAGPVPFGQIIGASIVCWVVSLAILPLQL
                     WLATWKGMFLSMGVGALGMIFGVLAATKPFWIAVPWSWAVRMVCPIINIHPNGTILEA
                     GDPLLNTSVIPIGIVVSLVVFIVLTALTAAWFNRRDDK"
     gene            complement(17428..18132)
                     /locus_tag="KNP36_000863"
     CDS             complement(17428..18132)
                     /locus_tag="KNP36_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HBF0872752.1"
                     /translation="MKDLILETKNLSKRYGEQMAVNNVSLQIERNSIYGLLGPNGAGK
                     STTLKMLVGLLRPTNGRIIFDRKPWKRESLAKIGSLIESPALYGNLTAEENLLVHTKI
                     LGIPKDKIYEVLEIVNLKNTGKKRASQFSMGMKQRLGIAIALLSDPELLILDEPTNGL
                     DPFGIQELRELIASFPKKGITVILSSHILSEVAQVVDNIGIINGGRLLFQGMPDPNEN
                     LEEFFTDVILKGGQNR"
     gene            complement(18387..18899)
                     /locus_tag="KNP36_000864"
     CDS             complement(18387..18899)
                     /locus_tag="KNP36_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872753.1"
                     /translation="MKKISQEKISTHIQEIPQEKIEQWKSLYEKYKSILKVNSKSVLE
                     IIEFLKRKYVIVEETSEEFKHVVINNIKLNKPFSQKISSDKELKPIVFTIPNEGNAKK
                     LYDTQEEIYSDCKIIVGMEFETGCVFVEGSDELNDEITSFKGLDKYDINNYYLVANYI
                     RCLKKYKLID"
     gene            19225..19482
                     /locus_tag="KNP36_000865"
     CDS             19225..19482
                     /locus_tag="KNP36_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872754.1"
                     /translation="MILNRAELFRGYSLNRFNEICNILSVNKIKYKYKVKNNAYSKKP
                     FFNEITLGNLGQKEDFSYEYLIYVHKDDYEQAESLINSKLR"
     gene            19625..20251
                     /locus_tag="KNP36_000866"
     CDS             19625..20251
                     /locus_tag="KNP36_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HBF0872755.1"
                     /translation="MKINIKSKLSEFIKQNNLFDDSRIISYLPNITIETDKIKTIMIN
                     EVVPTNTNDDFYSVDKDADYLKTTIPLFDSAGIKVSNINDILDMGIYITNAVKLPKSE
                     YTITRDTIKLHMPILEEEIKLFKNLEVVMLMGDVAKKSFNMITKKHIKKNVIPSISTY
                     KLRNNELYYDNLRVFPSYIMTGGNILIEKSKFEMASEDIKKMFEIING"
     gene            complement(20498..21277)
                     /locus_tag="KNP36_000867"
     CDS             complement(20498..21277)
                     /locus_tag="KNP36_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901940.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBF0872756.1"
                     /translation="MNSKIYYFSGTGNSLVVSNILKETLNGSKEVIPLAIHRKENNID
                     INEDILVIVFPVYFADVPDIVKSFVEKLNFNINTHIYAIATCNGVAGHSLFTIDKLLK
                     KRGKKLSAGFLINMPGNALITPPDVEEERLKNQTNRVAEIAKCINNLEIGNIEGKNNL
                     KSHIDSVVLRLVGKNMQIATTKFFAENKCNGCGTCKRVCPVENISIVDKKPKWGNECE
                     RCLACFHWCPKEAINVKKSFLTNRKKYHHPDITVKDIFLDK"
     gene            complement(21345..21806)
                     /locus_tag="KNP36_000868"
     CDS             complement(21345..21806)
                     /locus_tag="KNP36_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0872757.1"
                     /translation="MGGARDYLNGGKMKDFEKLYEATTKLVSTSLKVKDDLKKMFKQN
                     GYDITTDHYALLRFLWEQDGISQIDLCEKSCKDKSNTTRILDVMKNKGLIVRKVDVKD
                     RRKFQIFLTDLGRELEEPLNEIASIYATETFKSISDEELPLFTDILDRIGK"
     gene            complement(21782..22459)
                     /locus_tag="KNP36_000869"
     CDS             complement(21782..22459)
                     /locus_tag="KNP36_000869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0872758.1"
                     /translation="MIITVINGSPRKNGATSKVLTYLYKDIERLIPDVKINYFDLSEV
                     NPSYCIGCLNCYKMGKCINQNDKVEYIHDIITKSDGVIFGSPTYGSSVTGLFKVFTDR
                     AHMMLERLLYRKPCIAVTTYENARGSKAISFIKSMVLDSGGYVCGSLSIKTGFNQNPI
                     TEKVESKIQKVSKKFIYCIEEKKNPPVLSQIYNFIAINAVLKPMAFKDIEQYKGIIDR
                     WEEQGII"
     gene            22692..23078
                     /locus_tag="KNP36_000870"
     CDS             22692..23078
                     /locus_tag="KNP36_000870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0872759.1"
                     /translation="MKKLPHISEAEYQVMKIIWKYAPISTTEVIEKLVETSTWSPKTI
                     QTMLLRLVKKGALTYEKNSRVFVYTPLVKEEEYVATESSSFLNRFYNGTLNSMVLNFL
                     ENDKLSEDDIEELREILNKRTTKGDK"
     gene            23081..24880
                     /locus_tag="KNP36_000871"
     CDS             23081..24880
                     /locus_tag="KNP36_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaR1 family beta-lactam sensor/signal
                     transducer"
                     /protein_id="HBF0872760.1"
                     /translation="MYAPFFIRFLLSTLTLSILIAVILLAKKVFKKHISAKYQYNIGF
                     ILLIMLIIPFVPLKYINLGNVFNYLYTFNQLGSSTNRTSMIKNSPNSIINNSNALNDF
                     SVSLNQVNFDSLNILLLISWIIGILIMIAITIHCNIKIKNMKKSIQILRDEEIVFIFE
                     KCKKDIGINKDFILCKSPIINTPITFGYFKPHIILPDKSISKLSLKDIKYILLHELQH
                     FKNKDILINYIMCFLQILYWFNPLVWYAFKEMRIDREIACDISVLKKLDKDSHIEYGQ
                     TLINFVDNISRPSNLTLTSDIGGSKKQIKKRLLKIMDFHNESNTLKFKSILIFTLIAL
                     IVFGNIPKLSIMADINEKYRPTNEQTVYEDLSQYFKGFDGSFVMYDLKSKQYHIYNKE
                     KSKTRISPNSTYKIYSALLGLENGIITRNNSHIPWDGKHHSNSSWNEDQDLFSAMENS
                     VNWYFQTLDKKTGLKNIQTYLRQIGYGNYDVSGGISNFWLESSLKISPIEQVELLESF
                     YTNKFKFEDKNIETVKDSLLISKKDGVSLFGKTGTANINGKDVNGWFIGYVEKNENTY
                     FFATNIQSKDYSNGSSASKITLSILNDKKIYNP"
     gene            complement(25235..27109)
                     /locus_tag="KNP36_000872"
     CDS             complement(25235..27109)
                     /locus_tag="KNP36_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0872761.1"
                     /translation="MNKYNKIANELIKIIGEDNIISITHCATRLRVMVKDREIINDKK
                     VEKVDEVKGVFFTSGQYQIILGTGIVNKVYAEVEKMGLKTLSKKEQDELVKNNETGFK
                     KVMRTLADIFVPIIPVIAATGLFLGLKGCLFNDNVLGLFGMSSANIPLYIQTLVSVLT
                     ETAFAFLPAIIVWSAFKVFGGTPVIGLVIGLMLVSPILPNAYSVADPSNEIEAIMAFG
                     FIPIVGCQGSVLTAIVTAFIGANLEKWFRKHMPNVLDLIFTPFFVMLITMLVILLGVG
                     PIMHTIELKMVDIISLLIDLPLGIGGFIIGFTYPLAVITGLHHTYVMIETSLLANTGF
                     NALITLCAMYGFANIGTCLAFMKKSKNNQVKQTAVGAMLSQLFGISEPVLFGIQLRYN
                     LKPLIIMCASSGLGAAILSILHIQSNSYGLAVLPSYLMYIYDGYNLITYLLASIFVVA
                     FCFIVTCLFGVPKEAINEDEDEELVFNENNENFVSPAKGKIVALENVPDETFSKKMLG
                     DGFAIDIIDGKIVSPISGKLETVVSSGHAFGIKGTNGEVLIHVGIDTVALNGDGFDIA
                     VKQGDMVKQGDVLVNVDLKRIHELGKSTLTMVLFPDGKKVNILDINKDVKIGQRICVE
                     "
     gene            complement(27114..28778)
                     /locus_tag="KNP36_000873"
     CDS             complement(27114..28778)
                     /locus_tag="KNP36_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HBF0872762.1"
                     /translation="MEKKWWQKEIVYQIYPRSFQDSNNDGIGDLQGIISRLDYLKDLG
                     ITSLWLCPIFKSPMDDNGYDISDYLDIASEFGSMEDLKELIKKSKDRGIKIILDLVLN
                     HTSDEHPWFQEALKNPESPYHDYYIFKKGNDLPNNWRSVFGGSVWEKVENRDEYYFHS
                     FGKKQPDLNWENPILRSELYQMINTWSQMGVAGFRVDAITFIKKNLSFQSLESDGVDG
                     LVKCTKTVRNQPGIEKMLYELKENTFKKYDCMTVAEAAGISYDQLGDFIGEDGFFSMV
                     FDFKHADLDVASGSEWFKRISWTIPDLRKCILDSQMYVQEHGWAANFIENHDQPRATT
                     KYLLQYERNDDAVKMLGAMYFFLRGTPFIYQGQELGMTNFKRDTINDFNDLSSIDQYY
                     RSIDEGYSEEEALEFVNLRSRDNARTPFPWADKENAGFSDTTPWLKVIENYKDINAQS
                     QINNSESILEFYKKMIKLRQDSEYSDCLIYGSIEPIDIESDDIIAYRRQLDLVVIDCY
                     YNFSDKPVEIRVEEKYDIVFQNLDDINLLNKTVRLKPFHAVLLKVR"
     gene            complement(28792..29613)
                     /locus_tag="KNP36_000874"
     CDS             complement(28792..29613)
                     /locus_tag="KNP36_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBF0872763.1"
                     /translation="MKLYKLLILDIDGTLRDEVYGIPESAKHAIRLCQKNHCSVVICT
                     GRSMGTIQDDVLSLGVDGYIAGGGNYIQYHGELLYNQSFNQRLIKEVVCLLKNREVAF
                     SIESQEKVFMNQKAKEIFETMNQLKGTNSCINKQHIQEKITYENNIEEYKSQDIHKIC
                     LWSNEKVFDEVKDILQDKMELAQRDISSQYYEIIQKDFHKGKAIKRLQERLGVTQKET
                     ICFGDGQNDIVMFQASDVTIAMKNSHQQLKDIATSICEDIFDNGIYKELKRRNII"
     gene            complement(29712..30476)
                     /locus_tag="KNP36_000875"
     CDS             complement(29712..30476)
                     /locus_tag="KNP36_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0872764.1"
                     /translation="MKIEGLFNKYYNSFTANDKYICECILNHKEDCIKLSIDEFADKY
                     HISTSALSRFAQKLQLPGYSELRVIIRLNETEVEYKNQSKHQLMDCYNKVINDIEKKD
                     CSIMFERMKKANRIIVFGEGYSQERVAKEMKRIFLPTGKIIYDVYGYDMIQALNHFIK
                     TDDMIFFISLNGDASTIIDFAKEMRMKGIYMVSITKMISNPLARLCDENLYIQSISIS
                     VDKQLDYDVTTPYFILIELLYIKYKMYLESEHIPRK"
     gene            complement(30473..31222)
                     /locus_tag="KNP36_000876"
     CDS             complement(30473..31222)
                     /locus_tag="KNP36_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0872765.1"
                     /translation="MRLESLVNQNYDNLNENDKIIIKQILICQREYRNFSCEKIANEC
                     NVSRATLLRLCRKIGLDSFSDLKYLLKNNQLEFVNNDNNFHDVCENYRLLMNELQKIS
                     FQDICKIIYDAETIYIYGTGNEQKSLAQEIKRIFLSVGKCVIDLFDIGEIEFMRESFQ
                     KSDLFIIISLSGETKAGIEIAKFINNHIHTISLTRLDNNTIATLCEYNLYVETQKLDT
                     LQAISYEVVGAFYALLDLLHMNYIEYRRRKE"
     gene            complement(31726..32331)
                     /locus_tag="KNP36_000877"
     CDS             complement(31726..32331)
                     /locus_tag="KNP36_000877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0872766.1"
                     /translation="MKIKENVLMLDSTRGSNCFIVFDKEIILIDTGLPFMGKNIIKEL
                     KTLGIKLTDIKHILLTHHDVDHISNIKLLKEKTGAKVWAHVEDIPFIIGEKDRPGFKK
                     FIGKAISRRLIKDVEPYGENMQIGNIKIIHTPGHTPGHVCMIFEDVLFAGDLVKNKNG
                     NIVPYPNPWNWDYKKMMKSIRELDNLKYEWICMSHGTPCIK"
     gene            32510..33148
                     /locus_tag="KNP36_000878"
     CDS             32510..33148
                     /locus_tag="KNP36_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0872767.1"
                     /translation="MSELSKRDKEKIQRENEIIDKAEKLFCLNGFDNTTMNELAKEVE
                     YTKRTIYKYFSCKEDLFFAVVLRGYKRLWDNVKIESAKGKTGFEKIKLSYFAFHKFYS
                     VEPSLLCLMGMIGIVNSEKSDTDMLFKEKFFSFNKFMFDEIQGMFEIGKNDRSIRHDI
                     EIPTLMYSSIFTLTGFFNLLSVTGKSYLNNFNIDEEKFIETTLALLIDSIKA"
     gene            33280..33942
                     /locus_tag="KNP36_000879"
     CDS             33280..33942
                     /locus_tag="KNP36_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872768.1"
                     /translation="MAKILLLEDNDTITFGIKTSLEKKNHTVCCYNTIAEAKKNFDKT
                     IDLILLDLNLPDGIGYEFCQYVKSIEDTPVIFLTVRDDEKDIIRGLDMGADDYVVKPF
                     LLSVLQSRINAVLRRTHSNTNNTITCENISLNKVEVKAYLDNVEVPLTAGEYKLLLSL
                     MENKNRAMTRTKLLEMLWDVDGNFVNDNTLTVTIKRLREKLKNPPCIKTLRGIGYRME
                     DN"
     gene            33942..35123
                     /locus_tag="KNP36_000880"
     CDS             33942..35123
                     /locus_tag="KNP36_000880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872769.1"
                     /translation="MKTPRNINSTVVFIIFCLIVTFLLSVILTTITSFNEYNVLSKAL
                     GASYEYNPKSTESILKSLKNSSDKDFKTGNEILSKHGYSKSTFWSKNFFYFLVISFGI
                     ISTMATVVYIIKHRTNKQKLSRINNLTQYLEEVNLGKESVLLRCEDEFSHLEDEIYKT
                     VGELRCSKEFALKERQTLSDNLADIAHQLKTPITSMSLMAQLLSENCPDEEIDYINRL
                     TNQISRLERLVSSLLTLSKLDASTLIFESKLIDVHSLLTYAIEPIEGSLREKHQTFTI
                     EASPSVEFEIDINWTLEALLNILKNCSEHIEDGGYIVAYYSQNPLYVEIIIEDNGKGF
                     AQEELPYIFNRFYRGKNASKDSIGIGLALSKSIIERQNGTLHAENCHNGGARFIIKFY
                     T"
     gene            complement(35304..37964)
                     /locus_tag="KNP36_000881"
     CDS             complement(35304..37964)
                     /locus_tag="KNP36_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872770.1"
                     /translation="MNILQEYTLDFVRRNKRSSIAIMLAILLTTTMMSSLCGLLYTMW
                     TDFIKLSIEKEGNWHGELFDYTYGSDLPLIENFSSVDDVMVKGQWYVGKINDEKRDYI
                     IYRNATSEYWNSMPEKDTIIEGRRPNNANEIALSKQYFENNPSVKIGDKITLPIGDRI
                     LNGKPLEPIAPKSKGESFKKISEATLTIVGKVDVSTSSVIPAYTALGYLDKTSIKPND
                     SITVYLRFKNIRDTYKELPKLAKSLGWKTNEYGKYNLKYNSNYLLKMLVFSPEQKASM
                     SSISKFSTPIMYLTIAIFTVAVFVMVIYNAFSLSANARLTQLGILSSVGASPKQIKRS
                     VVFEGFLLTIIPLPIGLFLGWLLCNRLIVYVNSVNYHTDVPEVVFTYGIPAFLPAVLL
                     TIVTVWISALIPARKVSKISPIEAIRQGDSVKIKKSHKYSLGKIFGIEGELASNALRA
                     RKKSYRTATISLTLSFLLLTCFLHIIANQEGAKAVYGSDNYKDQRDIAVYLENSEPVE
                     SAFIEKLDNTEGVKSSLYYQKMSASTWLTEKDASKELAKNGGFKNIASSKKYSPIERD
                     GKFRIISNIIGLDDKSFTEYCRQISVDPKLFYDTKNPTSIVYNKEEDINRSTRRNKVY
                     IDYLNLSIGDNIKLNEKVYDEDKGDYTYNMKVGAITSTLPKIVDTSSKYTLMQIVPMS
                     MVQEISKNYDEVSRLRSNRLIGVFKVNNREDIPRVREKLESIYNKDYGSGDYSIEDVL
                     ESEKQKASGIKTMNLIVGFITGLLAMIGLSNVLATVSGNIRSRRQEFAMLRSVGLSPE
                     GIKKMLILEGLFLGITPLLLSIPVQIGIVYAFLRINEIYFIEYLPFAPISTIIGFTIL
                     ILFIVIASYMTGYKQLKNENIVESIKNETI"
     gene            complement(37961..38644)
                     /locus_tag="KNP36_000882"
     CDS             complement(37961..38644)
                     /locus_tag="KNP36_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872771.1"
                     /translation="MEILKCENLTKIYGSNQTRVTALNNVNLSVQKGDFVSIVGASGS
                     GKSTLLHLLGGVDRPTSGKIYVEDTEISSLKEEALAVFRRRKVGLIYQFYNLIPTLDV
                     RKNILLPMLLDKRKVDEDRFSEIVSILGLSDRLNHLPSQLSGGQQQRVSIARSLIYRP
                     AILLADEPTGNLDRKNSEEIVDLLNLSNKRFNQTILLITHDEKIALEANRIVTMEDGV
                     IVSEKVVKK"
     gene            complement(38988..39941)
                     /gene="blaCDD"
                     /locus_tag="KNP36_000883"
     CDS             complement(38988..39941)
                     /gene="blaCDD"
                     /locus_tag="KNP36_000883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDD family class D beta-lactamase"
                     /protein_id="HBF0872772.1"
                     /translation="MKRKKNFIWIAILLVGVVMVMYYVGKKHNDINQKTDKNYIKSEL
                     NKSELNKSKIENNNKNKKEKINMVDYSDCFEGISGGAIFYNTKNKEYNIYNKELIETR
                     RSPCSTFKIVSTLIGLEKGVINSKESVMGYDGTEYPNKNWNKNLSLEEAFKESCVWYY
                     KKLIDKVDAKSVQNILDDLKYGNCDISEWEGDLKNGKGHLNGFWLESSLQISPKEQVQ
                     TMAKIFEGDTNFKKEHINILRDIMKIDVNDKNINVYGKTGTGFDEKNKRVDAWFVGML
                     EREGDTYYFAIKSDDSNKEITGPKVKEIAINIIKKYYSVRE"
     gene            complement(40482..42596)
                     /locus_tag="KNP36_000884"
     CDS             complement(40482..42596)
                     /locus_tag="KNP36_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding domain-containing protein"
                     /protein_id="HBF0872773.1"
                     /translation="MSENKQVVNCDIIASNSKHNMCEYDAELLTFFPDEIAHLIEINN
                     KLDNAFKKAENLVDKLDKDYMDAKMYMVKNRGEIDPHEMFQNEQGLKQIDNYGAFMVK
                     VRDKINKIKDSPYFARIDFRLKDMDDESKYYIGRFAFDYEDELIILDWRSPIASMFYD
                     YEIGKAGYDAPIGWVDGEITRKRQFKIKNGKLEYALESSINIQDDILQKELSHTSDEK
                     MKSIISTIQKEQNQIIRNDKADTLIIQGVAGSGKTSIALHRIAFLLYRFKDKISANNV
                     IILSPNKVFGDYISNVLPELGEEPLCELSFENIAEVQLDRVINFESEKDPLEINDAKW
                     SERVRFKSTLDFVKLIDDYIKQMPNKIFIPKDYTFGSFTAKSDWIQSRFEAYNRYPVK
                     KRLEKVAEDIHYKFESDNIMEEDLPKVKSILKSLNGMLTIKNTLTLYKDFFKQMNISN
                     MFVMATKKTLEWSDVYPFIYIHAAYEGIQEDKIIRHVVIDEMQDYTPIQYAVINLLFK
                     CKKTILGDFGQLVNPNHTHTLDDMKQLYNDGELVMLNKSYRSTFEIINFAKKIQDISS
                     LEPIERHGEEPALLKCNNEQDEINKIKIEIEEFKKSDNATLGIILKTDNDAKAVYDAL
                     REKYSVHLISSESSSFTKGVSITSIKMSKGLEFDEVIVPSVNNKTYYSDYDRSLLYIA
                     CTRAMHKLKLTYTGELTQLIDM"
     gene            complement(42854..43714)
                     /locus_tag="KNP36_000885"
     CDS             complement(42854..43714)
                     /locus_tag="KNP36_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872774.1"
                     /translation="MSYKVINVITAIDYIEEHLSEKLDLDIVANAVHYSKYHLHRTFT
                     TSVGLTMHDYIKRRKLTEAAKLLVFSKKPIIEIALIAGYESQQAFTSIFKAMYKKSPN
                     KYRKEQEFYPLQLRFVLKKDNLFSKNVLELEKEIKLASMSDIPLWMNLVRLVIDGFPN
                     LQEEEYIYQLEQYILEERALILKLNNVAIANMVFNRETRSIDFFGIHPQYRNSDIAQV
                     FLKKVIEDFLIDTDISITTFREGDKADTGHRDMIKKLGFAEAELLVEFGYPTQKFILP
                     CVEERDNRQN"
     gene            complement(44309..44671)
                     /locus_tag="KNP36_000886"
     CDS             complement(44309..44671)
                     /locus_tag="KNP36_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBF0872775.1"
                     /translation="MKIYDILTRFYIQDIEKAIPFYENLLKEKCSLRFSYKEVGLELA
                     QIGNVLLLSGSDDALKPFIETKSTFMVDSVDEWRSYLLDNGAVVVRDKKKVPTGYNMT
                     LRHPDGTIIEYVQHTKQD"
     gene            complement(44905..45369)
                     /locus_tag="KNP36_000887"
     CDS             complement(44905..45369)
                     /locus_tag="KNP36_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBF0872776.1"
                     /translation="MTRISNITIAEQSEYCFLAIRKTIDFMVEFSEFSKQSFEKISKY
                     LEERGILSSGAPIVCFHNMDLAKLDVEVGFPVATYIDGKNEILQRIVPAQKIITAIDL
                     GPYELQDPTLEDLFSWANSNGYKLHGDIYYQYLNDINRPASEYLTKMMLPII"
     gene            complement(45798..47219)
                     /gene="nhaC"
                     /locus_tag="KNP36_000888"
     CDS             complement(45798..47219)
                     /gene="nhaC"
                     /locus_tag="KNP36_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="HBF0872777.1"
                     /translation="MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAA
                     AVAGLVAVYRLGFKWKELELSMFNSIKMAMQAILIIIIIGVLIGTWIVSGVVPCMIYW
                     GLKILSPNIFLVASTLVCAIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSII
                     SGAYFGDKLSPLSETTNLAPAMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSG
                     QALDIKQIELIRSTLDSTFNTLSPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFA
                     VVFQGESMNTILDAAQNGYVSSTQIQEVDALLSKGGIMNMMSTVSLTICALSLGGILE
                     KTGMLEVVASSLLRLAKGVFGTVLCTMVTCTITNIIAGEQYLSIVIPGRMYNKEYKKR
                     GIHPKMLSRALEDSGTLTSPLVPWNTCGAYITATLGVSALTYGPYALLNIINPIVSLV
                     LIACKFKIARIEDEPETCLNFDV"
     gene            complement(47249..48313)
                     /locus_tag="KNP36_000889"
     CDS             complement(47249..48313)
                     /locus_tag="KNP36_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine/ornithine racemase family PLP-dependent
                     enzyme"
                     /protein_id="HBF0872778.1"
                     /translation="MYPRLEIDIEKLKHNAKLISQMCHERNIKISFVTKSFCAQKEIV
                     EEICSEGIDHIADSRIQNLKNLQDINLPKILIRIPMLSELEEVINYCDISFNSELGTI
                     KKLNELCESKNIIHKIVLMFDLGDLREGYFYEEDFFSNVREIVRLKNIEIIGIATNLT
                     CYGAIIPSRENIGRLVSIAKRMEEKFGINLEIVSGGNSSSIHLLINNNMPEGITNLRI
                     GESILLGRETAYGENINGTYQDAFKLICQVVECKEKPSVPIGEIGVDAFRNKPVYEDK
                     GILKRAIIAIGKQDINIDSLIPIDTDIKILGASSDHMILDVSNTKYDYKLGDNLEFLL
                     TYGGIMSSSTSKYVSKKIIV"
     gene            complement(48298..49707)
                     /locus_tag="KNP36_000890"
     CDS             complement(48298..49707)
                     /locus_tag="KNP36_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate mutase L"
                     /protein_id="HBF0872779.1"
                     /translation="MENSKVSLKIDVLVAEIGSTTTVVNAFHDINTNNPIFLGQGQAP
                     TTVFEGGDVRNGLSGAIKDLANKLSVDDIEYNDMFATSSAAGGLKMTVHGLVYDMTVK
                     AAKEAALGAGAVIRQITSGRIKRTDLNKIKEINPNIILIAGGVDYGERDTAIYNAEMI
                     ASMNLGIPVIYAGNVENQEEIRLIFEDTNYKLYITENVYPKIDLLNIEPTRRIIQSVF
                     EEHITTAPGMKYIKEMVNENITPTPGAVMEASKLLYKNIGDLLTLDVGGATTDVHSVT
                     DGSDYINKILVNPEPTAKRSVEGDLGVYVNMKNIVEVIGKENLQSELSIDIDAVIENY
                     PPIPKSKEEILFVERLTKEAVVKAMLRHSGKIRNIYGTTGKVKIAEGKDLTEVRYIVG
                     TGGALTRLPSRIEILDNMLKYNKNNELLFPKEKTKILIDNDYIMASMGVLSKKYEEAS
                     LKLLLKSLNFEEERLCILG"
     gene            complement(49707..51911)
                     /locus_tag="KNP36_000891"
     CDS             complement(49707..51911)
                     /locus_tag="KNP36_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892628.1"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on
                     a cobalamin-like analog; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin-dependent protein"
                     /protein_id="HBF0872780.1"
                     /translation="MLKENKKLDIDYILKDLDKYKPKRRGWVWREHLENLEMGPFKYK
                     DCTKPLKKSVGLPSSKYFNNIDPQPSPVITTEIASGRFEDDIRRMRMAAHHGADHLMV
                     IRTAGQSHFDGLIEGTPQGIGGVPITRKQVRAQRKALDFIEEEVGRPINYHSYVSGVA
                     GPEVAVMFAEEGVNGAHQDPQYNVLYRNINMVRSFVDACEAKKIMAFANIAQIDGAHN
                     ANATAREAWKVMPELMVQHALNSIFSEKIGIDKSNICLSTVPPTAPPAPCLKIDLPYA
                     VALRELFSDYKMRAQMNTKYMESSTREATVTHVLNLLTSVLTRADIQSTITPDEGRNV
                     PWHIYNIEACDTAKQALVGMDGLMDMIELKDVGELRDKARELKERAVLYMEEISEVGG
                     YFESVEQGFFVDSGNYPERNGDGISRKIKGGVGEGTVYEREEDYLAPVTAHFGYNNVA
                     QYDENAIDNPSMLIDGCTFENPDKIIYIDELDDFDNVENRLKESYEYRNGTKIKPEME
                     WCADGIVMITMMLPTDKRTAEFAALEFVKKMNLQEIEVISREVMHESEGTRIEVKGRV
                     PFDIDLNNLVIPEEPKVLTDEEIRADIEEKPMKIVSATVGEDEHSVGLREIIDIKHGG
                     IEKYGIECHYLGTSVPVEKLVDAAIELNADAILASTIISHDDIHYKNMKKLHDYCVEK
                     GIRDKVMIACGGTQVTPEIAVEQGIDAGFGRNSKGIHVATFLVEKRREMSNK"
     gene            complement(51905..52279)
                     /locus_tag="KNP36_000892"
     CDS             complement(51905..52279)
                     /locus_tag="KNP36_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine aminomutase subunit alpha"
                     /protein_id="HBF0872781.1"
                     /translation="MKKREDDFEVRRKHLQELSDDELKERFWSLATQIVEPMIELGKK
                     NTTPSIERSVLLRMGFSSLEVKPILEGVMERGLIGKGAGHVVYKLAKSKNITVREAGL
                     LLVKGEYWDEVTCLFREGVESC"
     gene            complement(52357..53787)
                     /locus_tag="KNP36_000893"
     CDS             complement(52357..53787)
                     /locus_tag="KNP36_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent lyase/thiolase"
                     /protein_id="HBF0872782.1"
                     /translation="MNNSTSMKDMSYQAVMGRNNEIMKNAIGLDYSYFEQEGIGFDYE
                     KMMSETGYTLQDIEAIQSQYAVGNTPLIELKNLTKLARKCAKEGKGARIFVKDEAMNA
                     SGSFKARRAATAVYHAKQMGYKGVIAATSGNYGAAVASQAAMQGLKCIIVQECYDSNG
                     VGQPEIIEKARKCEAYGAEVVQLTVGPELFYTFLVLLEETGYFNASLYSPFGIAGVET
                     LGYELAIQFREKYKKDPDIVVCTNAGGGNLTGTARGLIKAGSINTKVVGASVDLKGLH
                     MASDNQFNKKSFTTGHTGFGIPYCTWPDRSDVPRSAARPLRYMDRYVLVKQGEVFYTT
                     ELLAQLEGIERGPAGNTSLAAAFSLAQELDEDKVIVVQETEYTGAGKHICPQLTFARE
                     NGIDIKFGNPREEIAGVNLILPERPELLKCVDIDMNKIRKSFIKNCISNNHIDNIDKL
                     SNRDIEFLMEEVKSSRDFVVDVLNNL"
     gene            complement(53780..54088)
                     /locus_tag="KNP36_000894"
     CDS             complement(53780..54088)
                     /locus_tag="KNP36_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-ketopentanoate thiolase"
                     /protein_id="HBF0872783.1"
                     /translation="MDAKINDWVIIHNIVLTPEERAPQVPEDTKKVSLEMWVKGFIQS
                     DASIGDLVEVKTITGRLVKGNLLKINPYYTHDYGKCIPELLQIGIQAKEILFGGVYNE
                     "
     gene            complement(54232..55299)
                     /locus_tag="KNP36_000895"
     CDS             complement(54232..55299)
                     /locus_tag="KNP36_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-binding protein"
                     /protein_id="HBF0872784.1"
                     /translation="MRKVRVGIWGFGAMGIGMANMILKKEGIEIVSVCSRSTSGKSMY
                     NVLGIERGERPEVIINKNYEEVFREKSVDVVLLATDSFTKKAFDKIIFLLNRKINVIS
                     TAEQMAYPQADDADLAKKMDEVAKENGVSILGTGINPGFVLDLLVLALSGTCEEVTSI
                     KAKRVNDLSPFGKSVMEEQGVGVTREEFIKGVEDKTIAGHVGFVESINMIADGLGWKL
                     DKIEQTKEPIMTIVDRKSKYGEALAGNVAGCRQCGYGYVNGEVLIEMEHPQQIIPEAE
                     GIKTGDYVSIKGIPNIDLQINPEIPGGVGTYAMIVNSIPLIINARPGLKTMLDIPVPR
                     AIMGDIRNQIEVELEEESKAN"
     gene            complement(55555..56928)
                     /locus_tag="KNP36_000896"
     CDS             complement(55555..56928)
                     /locus_tag="KNP36_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872785.1"
                     /translation="MNEILENIDEGVHFVNKDGKTIIYNNSVQKMEKMNRHDILTNSF
                     FDIVNKMKINRSTLLEVLEKREVIKDNIQKYLDKNGREITAINTTIPIDIKGEFVGAL
                     EISKNMTTIENLLNRNYKKNLVNKVSIRQKKGYEFDDILGESNLIKEAIAKSKKACKS
                     DASVFIYGETGTGKELFSQSIHYGSNRKNYPFIAQNCAALPESLFEGILFGTSKGGFT
                     GAIDRPGLFEQANKGTLLLDEINSMPIMLQAKLLRVLQEGYVRRVGGTKDIPIDVRII
                     ATTNESPKVILNEHKMRKDLYYRLNIIHIKIPPLRDRKEDIPLLCKKFISKYNKKLNK
                     KVVGISDEAIKILKNYDWQGNIRELENIIYCTMSMMEDEVQIETSMINLNDYYNLKEN
                     KESNNYSLNDLEDKTLSKIISEIEEKYIYESLEKASYNITKAASILGMNRQNLQYKIK
                     KYNIKIL"
BASE COUNT        19355 a         9709 c         6754 g        21237 t
ORIGIN      
        1 acttaatatt ttatataaaa atgaaaaagc acctcattct gattaaaaat ctttctgaga
       61 tactttttaa aatattaaat actacatata gcttacataa gtttaaaatt taatctatta
      121 taaaattacc ctaattgcca aactttttaa tataaatttt ccaacatcct acaaatataa
      181 tcaatagata tagaatccta acttacacca atatatattt atttaaaata gtcctaaaat
      241 acctgtaata gctcccacta ctatcagtat aaacattatt tttattggag aaagaccttt
      301 ttttaatgca aagagtacta ataaagtaag taccaaagga attaatcctg gaaatatctt
      361 atcaagtaaa tccgtttgaa gactaaattt aaaatcacca ctagtataac ttattggtgt
      421 agataaattg ataaacctac ctacaagccc ccccatgact aaggtaccta gtatagaagc
      481 cccttctata accttattta ctattccacc ttgaagtata ctttcaacag cttttttccc
      541 atacttatat ccatttgtcc acattccaaa agaaattgaa gtcattatta tatattgagc
      601 tattacaaat aatataggtc ctgcaattga tgctcctccc tcagttaaac caatacaaac
      661 agctaacact ataggagtta taactccttg agttaaagta tctccaattc ccgctagtgg
      721 acccatcaag cctgttttga tagcattcat accatctcca cttatttcat ctgctccatt
      781 agctttttct tcttccatag ctattgttat tccatgtata acacatccac atataggttc
      841 tgtgttaaaa aatgctagat gagtctccac ttcttgtttt aactcttcct tatctggata
      901 taatttttta agtactggca acattgaatg tgaaaaagct gttgattgca atctttcata
      961 attgtaatta gattgtgcaa agaaaaacca tcttaaccat gattttatta catctttctt
     1021 gcttaacgtt ttcttagata cttcattttt tatatctgac ataatatttt ccccctcaca
     1081 tgtatttaag atgtagcact atcttttccg tacttaattg aagtaattgt aagagcaagt
     1141 attactccaa taacagatat tactattata tctactttaa aataaacagc cattagtatt
     1201 cctaatatga aaaagggcat agtaaactta tttccaatca attttaaatt catagcaatc
     1261 ccaagtgctg gcaacatagc cccaattaca ttaaatacat gtaacacatt atcattcatt
     1321 acttccaaca taccatctat cgcatttgga ccaaaataaa caactaataa tgctggtata
     1381 aaactcattg caaataacag tatctgtggt ggtactatat ttataaatgc tactctatca
     1441 acattccctt tttgaacctc tctatcagcc caatgtgcaa aaaaagaatt tactgtcatc
     1501 tttccaatcc aaagtacagt tgcaacagtt cccaatggta cagctattgc cattgcagta
     1561 cttacatcta gcttagatgc tatagctaaa gcagtaccta catatcctgc aaaagctggg
     1621 tcccccatct gagctccccc tgctgatata aaacctagat atatcatatt tatacctgct
     1681 cctataattg ctccttgaac agggtctcct aatataattc ccgttacaaa tccagccaat
     1741 agaggtctat tccatgtaaa aaatccaaca taagtcaacc acggactcca agaaagataa
     1801 taaaaaattg ctattaatac tgcttgaatt agtgaaatgt gcatattctt cctccctatt
     1861 ttcttttaaa gatttacaag atagtcttct ttacaataat gttcctacat caattttctt
     1921 tgcatctggt actatttgta taaagcattt aacatctttt gatattagct ctctaaatat
     1981 ttctttttct tcatctgaca cagatatatt tttataaaaa ctttttctac caagccctgc
     2041 tcccatacct ccaacattca attcctttaa atctacccca ctatttacta aacctaagac
     2101 agttttaggg tatttgacca atactattaa attttcatct ccattatgtg attttaagac
     2161 ttcagcacct gattctacat catgtacttc aaccttaaca gttgatggag ctgccatttg
     2221 taaaacttga actataaatg ggtcctttac tactaaatca tccacgatta ctatcctttt
     2281 tgctgatgta atcttacacc aagcagtaat aacttgccca tgtattaatc tatcatcaat
     2341 tcttgttaat gctatattac tcataattat tcctccagat ttttaattta ttttacaact
     2401 ttaaaacagt tttaacatct ttgattcctg atatcccaac ttcctcacat aaattcttca
     2461 agtcttttaa cttcatagta tctctgttta aaaataactc taaaagcata ggtaaattta
     2521 cacctgtcaa acattctaac tcacatacct tagcaaattt atttattaca atagcagatg
     2581 tattaaatgg agttccgcca taaaaatcaa gcaatactaa aaccccttca tccttatatt
     2641 tctcaattcc atcttctaac tttctactaa actcatctat gctgtcacca tggtttaatc
     2701 ctaaagtttc tacattttcc tgtttgccta ctattaattc agcactttct aacattgctt
     2761 tagccatatt tccatgtgtg gctataatta ttcctgccat atgaatcata cctttcttaa
     2821 ccttttttat atggattatt atttagtact ctaatctaat tatctatatt aatcattatc
     2881 ttaccaaaga aaatatccct tttgtatact ttttcaaaat aagctggtac ttcttctaaa
     2941 tttattctat gtgttactaa tttttcaaca ttcatatcac ccttttgcat atgatacaat
     3001 ccagcactcc attcttttcc tgggaatgga aaggagtttc caaaccaagt tccctttaca
     3061 gttaattcac ttcttactat cttttcaaat tgctctctag tcaaagctac atccccatat
     3121 ggtacacctg catacaatac tgtacctccc tttttagcta gcaacagtac ttgaccacat
     3181 gtcagtggag taccagccga ttcaataaca atatctgcac catctccatc agttaacctt
     3241 tttatttctt ctacaatatt cttttctttt gcatttatac aaatatctgc ccctaactct
     3301 tttgccaagt ctaacttctc atcaaataca tccacagcta ttatttttgt agaaccaaat
     3361 atttttgccc attgtattga aaataatcct attggacctg taccaagtac tacaacagta
     3421 tctccaactt tagcttctga cctaaaaaga ccatgtcctg ctatacatac tggttctagc
     3481 gcagcggcag tctcataact tatctcatct ggtattttta ttaaatttct ctctttcacc
     3541 tttgtatact ctgcaaaaca acctccaagt tctttatttc ctattattgc tacattatta
     3601 catcttgaat acaagccttt tttacattca tcacattcaa aacatggcat agctggacaa
     3661 acagcaactc tatctcctat tttaaaactc cttacttctt taccaacctg tgccacttct
     3721 ccagaaaatt catgccctaa aatttctcca accatatgtg gacctgtctt tgaatatttt
     3781 gatatatcag aaccacatat tccagctact tttactttaa ttattacatc atctttttct
     3841 aatatttttg gtacatccac atcctccact cttgtgtctc ttataccata gaatctaact
     3901 gacttcacta ttaaccaccc ctacttttta tttgagaata tatccctatt gtttatatgt
     3961 taaatatcta aagcaacttt catgccaata tatgtaagca ttgtattcat gcattttata
     4021 aaattatcat taaatgtgtg tcaaagtgtg tcaaaagttt cttatattaa aacttatgtg
     4081 tgtcaatata aacgacacta acattttata ttagttctct tattataagt tttataaaat
     4141 gtactttttt tgttattttt ataaaattgt tcggaaattt cccttctatt tgtgatataa
     4201 tattaaatat aaggtatcaa tataaatttt catgcgaata tcagaacttt tttgacacta
     4261 atgccttatt caatataata atttaacttt ttggaggttg tttatgaaaa aagtgtatca
     4321 aggaaagact aaagatgttt ttgaattaga taatggaaat tacttactta aatttaaaga
     4381 cgatgtaact ggtaaagatg gagtatttga cccaggcgaa aatagtgtag gtctaagtat
     4441 agatggaatt ggtagagcta atttagagac atctgttaag ttctttgaaa ttctaaacaa
     4501 tgctggaatt aaaactcatt atgtaagtgc taatttagaa gaagcaacta tggaagttct
     4561 accagcaaaa gtttttggta atggattaga agttatttgt cgttatagag ctgtaggtag
     4621 tttcttacgt cgttatggtt catgtgttga agaaggtgct aaactagatt gttacgtaga
     4681 agcaacttta aaagatgatg accgttgtga ccctcttata acatctgaag gtttagaagc
     4741 tttaaacatt atgactcaag ctcaatttga ttcaatgaaa agcatgactc aaaaaatttc
     4801 taacatagtt cgtgatacta tagctgaaaa aggtcttgag ctttatgata ttaaatttga
     4861 atttggattc tacaatgatg aagtaatctt aatagatgaa atagcatctg gaaatatgcg
     4921 tgtttataaa gatggtgtaa tagttgaccc tatggattta actgctcttt tattagataa
     4981 atagtatata catataattt acaaatataa taaacttata aataagataa gctatgaagt
     5041 aaagactttt taaatgttga ttatttttaa acattttctc gcctttaatt tcatagctta
     5101 tttaaattaa tatactctaa ttagtagata atagctttaa ccctacaatt cccaccacaa
     5161 taaaacctat acatgcaatt cttgatatac taataggctc atttaaaata gccatgccta
     5221 caatagctgt accgacggta ccaattccag tccatattgc atatgaagtt ccaagtggaa
     5281 gatgttttag tgctaatgac aaaaaataaa aacttacaat cattccaaca acagtaagta
     5341 tacttggagt taatttagaa aatccatgtg aattttttag ttgaaaagcc caaaacactt
     5401 caaacaaacc tgcaacaaac aaaaataacc atttcataaa ttcatccctc ttttcaaata
     5461 tgtctcttat ttttccaata aaataacctg agaaatatta taaaatatct cccaggtttt
     5521 tgtccttccg tgttcacaac aaaaactatg ttgtgggttt tatctcggac cagaccaatc
     5581 attaataatt gcggaaccct ataaaactct attaattatt ctattttatc tataataata
     5641 ctatcaacat atataaaaaa agtcaatata tgggttccat atataataaa aataactttt
     5701 atataccttt taatattctt attcacttct ctccataccc atttgggtca atctaagaat
     5761 atctaatttt tatttaatat gttataataa cataaaaata ttgaaaggag taatttctat
     5821 gaatttctat aaaattgcag tatgtcagat gattactaca gaaaataaaa ttgaaaatat
     5881 caatcatgct gtagatatgg taacagaagc tgccatcaat ggagctaaaa ttgtagtttt
     5941 gccagaaatg tttaactgcc catatgaaaa taaatatttt cctaaatttg ctgaagaata
     6001 tccaggtgaa acaacaacga tattaagtaa attagctgag aaacatggaa tttatctagt
     6061 ttctggtagt attcctgagt tagaagatgg aaaaatctat aatacttgct atgtatttga
     6121 taaaaatgga gctctaattg gaaaacatcg taaaatgcac ttatttgaca ttgaagttac
     6181 aggaaaagtt agttttaaag aatcagatac tcttacagct ggaaatgatg tcactgtaat
     6241 agataccgaa tatggaaaag ttggtatagc tatttgctat gatattcgtt tccctgagtt
     6301 atcacgttta atggctctta aaggtgctga aatcgttatc ttacctgctg catttaatat
     6361 gactactggt cccgcccatt gggagttatc tataagaatg cgtgctttag ataatcagat
     6421 attctatgtt ggtgctgcac ctgctagaaa tatgaatgct tcttatatag cttttggaaa
     6481 ttcaagaatt tcagaccctt ggggaagaat aattgctcaa gctgatgaaa aagaatgtat
     6541 tatttatgct gacattgata gagatttaat tcctgacata agacaacagt taccacttct
     6601 taagcacaga agaactgatt tatatgaact taatactttg aaataaaaca gaacataacc
     6661 ccataaatca taaattaagt gttaaaaaaa tttatggggt tctcattaat ttgatttaaa
     6721 attaatttca taaaaataat gctaatatta atttaattaa ataatactaa taattactaa
     6781 tgattatgct aattatcagc atttactaat ttaatcacta ttagttattt cttttattaa
     6841 atatctttac ttttttactt attatgtctt ctagctttac atttggatta tggtatttct
     6901 ttctattttt agtcacatct ttctattgaa ttacttgctt aaaacaccaa tgcacacatg
     6961 ccagataatg ttcacaatta tttagaaatc ttgctctacc ttcttcaatg ttgatattat
     7021 ctctcctagt tgatattatc tttcctaaaa tttcttttaa ttaaaaaaca acattagttg
     7081 atatatcaag tatattttaa gcaactgaaa aaaacaataa taattgatat atcaactaat
     7141 taatgtagat taattcattt ttataattta tatacttttt aattaatcta ccttatttaa
     7201 ttaaaatcct tcctttctat ttatccattt tcaacttaaa ttataagatt tcatcagcta
     7261 tatttttgca taccaataat tattaaatat caaatatata ttctattaaa atttctaata
     7321 atttcatcct tgatttattt aatatataaa aatatactaa ctttaatgat taagttttga
     7381 aatataacta agaatttgat aatttattga gatttttata ctaaaatata catactatac
     7441 aaacttaatt tagaagggag cattcttatg aacaataaaa tactcgtcgt agatgatgag
     7501 gaaggtataa taacactctt aaaagattac tttgaaatga atggttatga ggtttacact
     7561 gctcaaagtg gaaaagacgc attaaaaaaa atatctaaaa atccagatat cattctactt
     7621 gatataaaca tgcctgaaat agatggaatt gaagtttgta atagaattag agattatgta
     7681 tcatgcccta ttctatttct tacagctaga attgaaaata ctgacaagat aaatggtttt
     7741 cgtgctggtg ctgatgatta tattgtaaaa ccttttgatt tagacgaact tggagctaga
     7801 gtatctgccc atttaagacg tgaacaaagg aagtcaaatc aaactaaaat taaattttat
     7861 aatgatttaa caatagatta cgaaaaaagg ttaatttgta tatataataa tcagatttca
     7921 ctttcaaaaa aggaatttga tatagtagag cttctctcta tgaatcctgg acaagtattt
     7981 gataaagaaa aaatatatga tagagtctgg ggatacaata gcaatggaaa tagtgatgtt
     8041 ataatggaac acattagaaa aatacgaatc aaactatcaa aacatactct tgaaaattat
     8101 atagaaacag tctggggagt tggttataaa tggataaaat aaataatatg tcattaaaaa
     8161 aagctttctt tgttcttact ttatcttcac taattatagc atcagtgctt actactttcg
     8221 catacatttt acttaataat ctatataatt ctatacaaga taagtattta aaaacaccta
     8281 taaatacagg tattataacc atagttcaaa acaatgtgaa ccaatttagt gattatgata
     8341 aaacattact taatataatc aacatacttc agcttgtact tccacttatc ttttttatag
     8401 gacttttatt attagctgat ataatttttt acaaggtaaa attaaaaaca cccatagaaa
     8461 tactcaataa aggtgcaatg gaaatatcca acaacaattt agacttttgc ttagaatata
     8521 ataataatga tgaattaggt aatctatgta atgcttttga aaaaatgagg tctgaactaa
     8581 ataaaaacaa cataaagatg tggactatga ttaatgatag aaaacaactt aatgctgctt
     8641 tttctcatga tttaagaaat cccctaacag ttctaaaagg ttactcaaac tatttaacaa
     8701 aatacatacc aacaggtaag cttagtgatg agaagatttt atcaaccaca caacttatgt
     8761 ctgagcatat taacagaatt gaatactatg tagaaaatat gagtaatgct caacgattag
     8821 aagatttagt tgtttcaaaa tctatgtcga atataaacaa gtttatagaa aacttagatg
     8881 aaaatatatc tatcattgct aaacaagaag gaaaatcttt tacacttaaa agtcaaataa
     8941 ataatataaa tctatttttt gatgaaaata tcattcttag agtcgtcgaa aatataatat
     9001 cgaatgcttt tagatatgct agaaataatg tatccatact tatatatctt gaacaagaac
     9061 tccttacctt tgtaattgaa gatgatggta taggatttag taaggaatct ctaaaattag
     9121 ctttaagacc tttctataga gataagactt taaatgacag caatgcacac tttggtatgg
     9181 gtctttatat ctcaaaaata ttatgcgaaa aacatggtgg ctctatttct attgaaaata
     9241 attctactaa cagtgctaaa attactgcta aattctcaac aagaaattaa aatgattttg
     9301 taagctttca ctgttcttat ataaaatttg ttagtttaga atttataaaa tgtatttcaa
     9361 tttacaacca atatatatac tattttgtag aagttgtaag agttgcttca attataatat
     9421 ttggcaaaag gcatttgaaa taataataga aatatatatt taaatatgta gaatagtatg
     9481 aaattagaat tttggaggtg attatattaa aagttttgct aataatatta cattctctcg
     9541 tattgtgttt gcattgctaa tgcttagttc tacattctct tcactgcctt tctggatatg
     9601 ttatttttgg tgtggaatta gtgatatact tgatggtctt attgcccgaa agttgagaca
     9661 acaaagtgga ataggtgcaa agttagatag tattgctgat ttcatttttg cggttacaat
     9721 tttggttact gtcggaaaaa atattgctct tcccatgtat ctatggtggt gtattgttgc
     9781 aatagcattg ttacggttga ttagttacag tattggtttt tttaagtatc gcacattttc
     9841 atcgcttcat actttgatga ataaaatcac tggaatttct atctttgctt ttccattact
     9901 ctatatttgc tttggtcttg atgttgcagg aattatgata tgtatcgtgg cttttctttc
     9961 ttcttttgaa gaaatagcaa ttatgataaa atcaaaagaa ttaaatcgtg atataaaaag
    10021 tatatttatg tgacaactta gaatttgtga caaaaataat ttatataata atgaggaagt
    10081 aaaacataaa aaattatcca caagtttatg tgtaaaatag ttttaaagca atagagttgt
    10141 attgtaaagc ctttagtgca taaattacat tttaaattaa aaatgatact gaaactgctt
    10201 atcagcactg cgaattatcc gcaaatagtg aagacttttt agatttaagc taaaagttgg
    10261 gaaaaaattg agttttaaaa cttacactct tcttatatag aaaaggagag tgttttttat
    10321 gattataaaa gcaaaacaat tatcaaaaat atatggttct aataacaata aagttatagc
    10381 acttaataat gtaaatttag aaataaactc aggtgaattt gtttctgtaa ttggaccttc
    10441 tggaagtgga aaaagcacac ttttgcatat tttaagtgga ttagataatc ctacctctgg
    10501 acaagtgtta cttgatgata aagatatata taaacacact gaaaaagaac tatctgcact
    10561 tagaagaaaa tcctttggat tcgtctttca acaatttaat cttttacctg ttcttacagc
    10621 atctgaaaat atttcaatgc ctgtacttct agataaaaaa caacctgata aagactattt
    10681 aaatgaaatt tcatcattac ttggaattgc agatagactc aatcatcttc cccatgaact
    10741 ttcaggcggt cagcaacaaa gagttgcaat tgctagagca cttattgcaa aaccagatat
    10801 aatatttgct gatgagccta caggaaactt ggacagtaaa agtggcagtg aagttatgaa
    10861 tcttcttata aaaacttcaa aacagtttgg aaagacttta gtggtaatta ctcatgatga
    10921 tagaattgca aaacttgctg atagaaaaat ttcaattatt gatggtgttc ttatggaggt
    10981 gaaatagaaa tgaagaatta cctttcactt tcaataaaag aattaaaaag ccagaaattt
    11041 atgactacat tcatcattat agcaatagta ctatcaacta ttatgacaac tgtggttgga
    11101 cagtcaattg gtatcctaca aaatttaaga attgaacaag cccgttcttt taatggtgat
    11161 agacatgtat cctttcacca actcactaaa aatcaagttg atgacataaa gaaagatgat
    11221 agagtttatc aagctggtac ttcaataact attggcagta gtaaaataaa ggattctggt
    11281 atctctgtac ttgtaaaaga gtatgataaa acaggacttt ctaactaccc aaaattaatg
    11341 aaattaaaat ctggacattt gcctaaagat aaaaacgaaa tagccttaga tgaaaacaca
    11401 ctaaagctta tgggtataaa accaagacta ggagtgacta tacctatgaa tttagatatt
    11461 tcacttttaa atgataccat accaccatat aattacacag ctaactttaa attgagtggc
    11521 attttagagg atgattatac aggatatgta agtggtatag taaatggtat tgtaggtaaa
    11581 ggtacatcag aaaatctatt acctaagaga tatattttat cctctttgga ttttaaaata
    11641 aaacagcaag aaaagtttca agaaatagta aatcaattag ctaaaaaaat aaatctttct
    11701 cacaattcaa ttcaatataa ttggatttac ttaaatgctc ttaagataca gtttgaaaaa
    11761 gatgaaaata gttctaatag tgatggtata tctatgatta tattggtatc tttatttgtt
    11821 gccttattgg ttttactggc ttctggactt gtaatttata atattttaaa aatctctgtt
    11881 acaaagaaaa ttaaagagta tggatgttta agagcaatag gagctgaacc aaaccagata
    11941 tataagatag ttattttaca aatcttaatt ttatgtactg ttgccatacc tattggagct
    12001 gtaattggaa ttatatcttc taaaggcata actggaatgg tcactaatat cttaaatcca
    12061 gatatacttc tagcaaatga taataaagaa attactgagc ttatacataa aaatacaaca
    12121 gcatatatat tcccattagt attaagcact aatgtatctt tgattttttc atttatttca
    12181 gcattaccat cagcaatata tgcttcacat gtctctccca aaattgctat ggttggtagt
    12241 actaccaaaa tcaaaagaaa aattaaaaga gaaaaaacaa taaaaaactt tgaaagacat
    12301 ctagcatggc taaacttaaa aagaaataaa ggaagaacta taataactat actatcatta
    12361 tttatgagta taacagtatt cgttgcactg agtgagttct ctaatgtatt agatgtatct
    12421 aggtcagtaa gtaatttaaa agaaggagat ttttccttaa caaatgaaat atctggtttt
    12481 gataaatcaa cactagataa aatagctaaa atgaaaaacg tcaatcgcac ttcctttata
    12541 aagtactctg aatacaaaca gggtgaaata gatacagata taaattttga aaatagtggt
    12601 gagatgttaa aaatcattgg aattgatgag caaactttaa aagacttaat gccttctatt
    12661 acagattcta tactagaaga ctttaaaaat ggttctatct gttttataaa aaatccgatt
    12721 gctatttcta caccaggtgt aaaaactaga tatacaaatt taaaacctaa agatagtatc
    12781 acaatcaaca aaaaacaact agatatatat agtacagtag ataaaatgtt ctttttacaa
    12841 ggcaatggct ggataaatgg tgttgatgtt attgtatatg attctgttta taacactttg
    12901 acaaataaaa acaagttcaa ccagataaat atttatgcta aagataaatc aaaattagaa
    12961 caaataagat tgtctattga acagatttgt gaaaataatc ctggctctca ttggatatca
    13021 tatattgaat cagataaaca acttaaagag agttttaaac aaatagaatt tctagcatgg
    13081 gcagttatat tatttgtggg attgattggt actttaaaca tcattaacac aactcataca
    13141 aatataaata ctaggactaa tgagattgga gttaaaagag ctattggtat gagtaatagg
    13201 agcttatata aaatgttttt atgggaaggt gtttattatg gaatttttgc tgctatattt
    13261 ggttcaattg ctgggtatgc cagtgctatt atcataaaca tggcaactat agaaaagctt
    13321 gatttcacta atataccaat tacttcaatt ttacaagcta ctattatttc tgtacttgca
    13381 tgtattatag ctactcttat tccgttaaga aaagttaaaa agatgaatat aattgactgt
    13441 atagatatca atttataact attttacaga taataatata aattaaatta tcaatgactg
    13501 tctctatttt ctttcaaatc taactaataa atctttttaa ctataatata agctttaaaa
    13561 aaggcctgtc tcaaaataga gataagcctt ttttcattgt cgaaataatg aaaatatatt
    13621 taacttcaca aaaaaagagt gcctcacgaa ttaaaaattt cgctttgaga cactctcctt
    13681 taatttaaaa tatatagtta aatgctatgc caaaatttca cacatgctcc acctgatttt
    13741 gaattttcta ttttaacaga acctccaagc tgttccacta attgtttgac aatgtaaagc
    13801 ccaagaccag aatgtccacc ttttgtctgc ctagcttcat ctcctcgata aaatttatca
    13861 agagcctttt ttaaatcttt agagctaaac cctctaccag aatcacaaat ctcataagaa
    13921 atacaatttt tttcatcctt tacagtaata ctaatattac cacctgatgg agtgtattgc
    13981 agactgttgg atatgatatt atcaaaaatt cgtgtcaacc tatcaacgtc gatttgaatt
    14041 ggggattgta tattcccctg cattttcaat ataagttcaa cttccttttg atgagcctgt
    14101 aattcatagt cttgcacctt ttgcctcaaa aattcaggta aatttatagg aacaagattt
    14161 aattgtatat ttgacttttc taagtcagac gtatattgca tcttttggac aagagcagca
    14221 cttttttctg tattttctct tatcactgta agatacctat gaagtttttc attgtcatct
    14281 gtattattac caataagtgc atctgtatat cccaaaataa tagaaagagg agattttaaa
    14341 tcatgtgcta gagcttccac catttcaaca cgttcctgct ccatcttcca ctgtgcagat
    14401 aaagagcctt ttaattcgtc tttcatttca gaaaaggcac tacaaagttt accgagttca
    14461 ttatctgaat aatagtcgat ttcaaaatca aggtcctttt cttttatctt cttggacgca
    14521 tcaatcaata gatgtaatgg ttgattgata ttctttacaa agcgcttaga aagccatcta
    14581 gtaaaaccca cgatatatag aaatggagaa aacaaagcca ttataataac tgcaaataca
    14641 aatctccctc taatatttgc aaaggtgatt ttcacttggt agaatagaat aacagcaccc
    14701 tcaatctttc cattatcccc tttgattgga acagtatgga tataaccacc tttacgaaca
    14761 gttttattga taaaattatt aaataattct tcttttgttt taaatagttt tttggggtta
    14821 gtaccatata aaatattgcc attattatcc acaacttgat atagcatatc atccccacga
    14881 atcgttcttt ttaaaccttc ttcattcgat tgtgataaca aagctatgtt tttttcattg
    14941 atgtattttt caattctagg aacttgtcgc tcataatagt ttggtggata gatatcctta
    15001 tttaaggaat gaatatacaa atagagagca aatacataag taatcactgt ggcaactata
    15061 ctggctatta taataaaaat aaaagtatgt ctaaattggg taataaggga ttgatttttc
    15121 atttaataac ctctctctct ttacatttta ttccacttat acccaatacc ccaaactgtg
    15181 gaaatatatt ctttttctgg tgtcacagca gaaaacttag ctcgtatttt ttttactcgt
    15241 tcaacaacag ttgaggaatc accttcagaa tcacaccccc atactttttc atagatttgt
    15301 tctcttgaga aaacttgtcc tgcatggagt gctagtaatt caacaatatc atactctatt
    15361 tttgttaaat caatattctt accatcaatt ttaattgcac gttccttcat atataagcat
    15421 aacttcccaa aatacaaagt agatctcttg ttctcttcat tgatatactg tgaacgcttt
    15481 tccctacgca gattagcttc aatccttgcc ataagttcac gcagtccaaa tggctttgtt
    15541 acataatcat cccctccaaa ggtcaaccct ttgattttgt cggtttctga ttgctttgca
    15601 cttaaaaata taattgggca taaaacatca tctctaattg cctgacatac ctcaaatcca
    15661 ttcattttag gcatcataat atccagtata ataaggtcag gctcctgttt tgataactct
    15721 atacctgcct gaccatcata agctatcaac acttcatgtc cttttgcctt caattcatcc
    15781 tcaagtagca ttactaggtc catttcatca tcaataatca atattttact caatataaca
    15841 ccacctttct cttatgggaa ggtcagtatt aaaacaatat tcgtctactc ataacttttc
    15901 cttccctccc acattttaaa ccaaataacg cctcctatca agaatataat caaacctatt
    15961 gctactacta taagctctat actagctgtt tgcatcactt tagagtaaaa tgcctcagtt
    16021 gaaatagttc cagcttcttt aataaaataa attcctggaa gcatacctag ttttactggc
    16081 catgtccatg gaacaaatgc ccatactttt tcaccaacgc tagttaatcc aagtattgct
    16141 gccatcaaaa ttccaccaat actaatacca atagatgcac ccatacccca tgcaaaactc
    16201 acccaaagat gaatagctaa tagtggaagt gtcccaatca ccacaagtcc tgctgctgac
    16261 aggaataacc atattgttgc tccagatggc actgcaatac tcattcctat gcaaagtatc
    16321 aacgtagcaa taaatgtgca tatagttagg caaaacagaa gaaaaagaaa ttttcccaga
    16381 tataatctga cacgagaaat acctacacat aaaaaaccat taaaatttcc agcaagctct
    16441 tcctcctgca ctataaatcc tgctaaaata cctactccaa taggaatgat gaatacagtc
    16501 catactgtaa aaaatccttc aaaagcaaat tcttgtgtac ttccagattt agttgtgaga
    16561 taaaaaacca cacataatga aaaaataata ggcatacaaa gagtaagcca ctggacagct
    16621 gtcctctttg ctcgaagcca ttctgatgat aatagtttta tcatttgtca tccctcctat
    16681 tgaaccaagc tgcagtaagt gctgttaata ctataaacac aaccaaagaa acaacaatcc
    16741 caataggaat cactgaagta ttcaaaagtg ggtctccagc ttctaatata gtaccgttag
    16801 gatgtatgtt gatgattggg cataccattc taactgccca actccaaggt actgcaatcc
    16861 aaaatggttt tgtcgcagca agaacaccaa atatcatacc taaagctcca actcccatac
    16921 ttaggaacat acctttccat gtagctagcc atagctgaag tggaagtata gcaagagaaa
    16981 caacccagca tacaatactt gcccctataa tctgtccaaa aggaactgga ccagctttca
    17041 atattaaacc agttataatt gttacgacta ttaaaactag cgttgaaata aaactgtaga
    17101 ctgccatagc tataacttta ttaatccaaa gtgtcatagg agacacattg tgtgtacgta
    17161 aagcacgata atttccagct tttttttcct ggaaagctac caaagtagcg aacaatgcaa
    17221 atccaatagg cagaaataaa aatgaccacc agttaaaaat taatgctaaa agattttgcc
    17281 acgcccaaga agttgtttga gataatggat tttgcatgag tgttgattgc attataaatg
    17341 catatgctgc aaaagacact gggaaaaaaa caataagttt acccataaat gttcttttat
    17401 actttaaaag ttctgattgt aaagcattca tctgttttgt cctcctttaa gaataacatc
    17461 tgtaaaaaat tcttctagat tttcattagg gtcaggcatt ccttgaaata atagtcgtcc
    17521 tccatttata attcctatat tatctacaac ttgagcaacc tctgatagaa tatggctaga
    17581 aagaattaca gttatacctt ttttgggaaa agaagcaatc aattcacgca attcttgaat
    17641 gccaaagggg tcaagaccat tggttggttc atctagtatt aacaactctg ggtcactcaa
    17701 aagtgcaata gctattccta acctttgttt catacccata gaaaattgtg aagctctctt
    17761 tttacctgta tttttcaaat ttactatttc caacacttca taaattttat ctttaggtat
    17821 tcccaatatt tttgtatgta ctaacaaatt ttcctctgct gtaaggtttc catacaatgc
    17881 aggggattct attaaagaac ctatttttgc aagagattct cgtttccaag gctttctatc
    17941 aaaaataata cgaccatttg ttgggcgaag aagaccaaca agcattttaa gtgttgtgga
    18001 ctttcctgct ccatttggtc ctaaaagtcc atatatacta tttcgttcaa tttgtagaga
    18061 aacattgtta actgccattt gttctccata tctttttgat aagttttttg tttcaagaat
    18121 taaatctttc atattaattt ctcccttctt gtaatacctt aaatctgtta ctaagagaat
    18181 actaacatga aaaaataaca attctataac acctactaat tttaataaaa tttaaaataa
    18241 aaaatagagt taccaatttt attttggcaa ctctatttaa gtttatgttt tacagttata
    18301 ttagatttaa acttagtttc attatcacac taacttcaaa tttactctat aatctttaaa
    18361 tcaaacacta atttattaat caaacactaa tctattaatt tatatttctt tagacatcta
    18421 atatagtttg ctactaaata ataattattt atatcatatt tatctaatcc tttaaaagaa
    18481 gttatttcat cattaagctc atcactacct tctacaaaaa cacaacctgt ttcaaattcc
    18541 atacctacaa taatcttaca gtcactataa atttcctctt gagtatcgta caattttttt
    18601 gcatttcctt catttggaat tgtaaataca ataggtttta attctttatc actggaaatc
    18661 ttttgtgaaa aaggcttgtt taacttaata ttattgataa ctacatgttt aaattcctct
    18721 gaagtttctt ctactattac atattttcgc tttaaaaact ctattatttc taaaacagac
    18781 ttagaattta cttttaaaat acttttatat ttttcatata aagatttcca ctgttcaatt
    18841 ttttcctgtg gtatttcttg gatatgtgta cttatttttt cttgagatat ttttttcaat
    18901 taaactctcc tttcaatact taaatatcct tatgaatctc acatgactaa agttacaagg
    18961 tttctactta atagaatttt gcatacttaa atatgtctta ttaattctct acaggatatc
    19021 tccgtagttc ctacgattct tacataagtt acttatttta aattgttatt agttatattc
    19081 taaaaattat ttattttatc actaatataa tactcttaaa aactttacaa atcaatttaa
    19141 atttgctacc ttttatttat aacaacttat agtacatttc tcctatgctt ttcaatatat
    19201 tacttttaaa aggaggtttt cattatgatt ttaaatagag ctgagctttt ccgaggatat
    19261 tctttaaata gatttaacga gatatgcaat atattatcag taaataaaat taaatataag
    19321 tataaagtga aaaataatgc ttactctaaa aaaccttttt ttaatgaaat aacacttggc
    19381 aatttaggcc aaaaggaaga tttctcttat gagtacttaa tttatgttca taaagacgat
    19441 tatgaacagg cagagtctct aataaattct aagttgcgat agattatcta taaaacatga
    19501 cattctgttg tcatgtttta tatgttatta tactttcaaa tatgctacta tattttcaaa
    19561 attgtgtgct ttaaaactag ctttttttag taatttaaag cttaaaacta aggagactcg
    19621 ttatatgaaa ataaatataa aatcaaagtt aagtgaattt attaaacaga acaatctttt
    19681 tgatgacagc agaataatat cctatcttcc taatataaca atagaaacag acaaaataaa
    19741 aactataatg attaatgagg ttgtcccaac taacaccaat gacgattttt atagtgtaga
    19801 taaagatgct gattatttaa aaactactat tcctttattt gacagtgcag gaataaaagt
    19861 atctaacata aatgatatcc tagatatggg tatctatata actaatgcag taaaacttcc
    19921 taaatcagaa tatacaataa ctcgtgatac aattaaatta catatgccta ttttagaaga
    19981 agaaattaaa ttatttaaaa acctagaggt agtaatgtta atgggagatg ttgcaaaaaa
    20041 atcttttaat atgattacta aaaagcatat aaaaaagaat gtcatccctt ccatttcaac
    20101 atataaactt cgtaataatg aactttatta tgataattta agagtatttc catcatatat
    20161 tatgactggt ggaaacatac tgattgaaaa atcaaaattt gaaatggcat cagaagatat
    20221 aaaaaaaatg ttcgagatta taaacggttg atattacaaa ataataaaaa ctaatataaa
    20281 ataaaaagtg cctcaaaaac ttctatttat gaggcacttt tattttatat tagtgtaact
    20341 atatactatt aacataattt attatttata ttgttctttt taatctctat tccatttagt
    20401 ctaggtaaca ttactcttta caagattact ttatatttct tttatatctc taacgttttt
    20461 atttaataaa acaattatta atacaagtca aatatatcta tttatctaaa aatatatctt
    20521 ttacagtaat atctggatgg tgatacttct tcctattcgt taaaaaagat ttttttacat
    20581 taatagcctc ttttggacac cagtgaaaac aagctaggca tctttcacac tcattacccc
    20641 actttggctt tttatcaact atacttatat tctctacagg acaaaccctt ttacatgtcc
    20701 cacatccatt acatttattt tctgcaaaaa atttagtagt tgcaatttgc atattcttac
    20761 ctactaaacg aagtacaaca ctatctatat gtgactttaa attgtttttt ccttctatat
    20821 ttccaatctc caagttattg atacattttg caatctcagc taccctatta gtctgatttt
    20881 tcaatctttc ttcttcaaca tctggaggtg ttatcaaagc atttccaggc atattgatta
    20941 aaaaaccagc agataatttt ttcccccttt ttttaagtaa cttatctata gtaaataaac
    21001 tatgtccagc taccccatta caagtggcaa tggcatatat atgagtatta atattaaaat
    21061 ttaatttctc tacaaaagac tttactatat caggaacatc agcaaaataa acaggaaaaa
    21121 caattaccaa tatatcttca tttatgtcta tattattttc ttttctatgt atagctaagg
    21181 gtataacttc tttacttcca tttaacgttt cttttaaaat atttgaaact actagcgaat
    21241 ttcctgttcc agaaaaataa taaatcttac tattcattct tatccctctt tctatatttc
    21301 tacatcatca atagttaaaa agtctcttaa aataggattt atatttactt tccaattcta
    21361 tccaaaatat cagtaaacaa aggcaattct tcatcagaga tagatttaaa tgtctctgtt
    21421 gcatatatac ttgcaatttc atttaatggt tcttctaatt ctctacctaa atctgttagg
    21481 aatatttgaa acttacgtct atctttaaca tctactttac ggacaattaa tcccttattt
    21541 ttcataacat ctaaaattct tgttgtatta gatttatcct tacatgattt ttcacataaa
    21601 tctatctgag aaatcccatc ttgctcccat agaaacctta ataacgcata atggtcagtt
    21661 gttatatcat atccattttg tttaaacatc ttttttaaat catcttttac ttttaacgaa
    21721 gtacttacta acttagttgt agcttcatat agtttctcaa aatctttcat tttacctcca
    21781 tttaaataat cccttgctcc tcccatctat caattattcc cttatattgc tcaatatctt
    21841 taaaagccat tggctttaaa acagcattta tagcaataaa attatagatt tgagaaagca
    21901 caggtggatt tttcttttcc tctatgcaat aaataaattt tttagatacc ttttgtatct
    21961 ttgattctac tttttcagtt ataggatttt gattaaatcc agtttttata gataaactac
    22021 cacaaacata acctcccgaa tctaagacca tggattttat aaaagaaatt gcttttgaac
    22081 cacgtgcatt ttcatatgta gtaactgcta tacatggctt acgatacaat aatctttcaa
    22141 gcatcatatg tgctctatct gtaaacacct tgaaaagtcc agttacacta cttccataag
    22201 ttgggctacc aaatataaca ccatcactct tagtaattat atcatgaata tactctactt
    22261 tatcattttg attgatacac ttgcccattt tataacaatt taaacaacca atacaatatg
    22321 atggatttac ctcacttaaa tcaaaataat taatttttac atctggtatt aatctttcta
    22381 tatctttata caagtaagtt aaaacttttg atgtagctcc attttttcta gggcttccat
    22441 ttataactgt aattatcatt tctatatctc ctttttagtt gttatatcaa caataagtat
    22501 atcaactata attttagctg tcaatataaa ccatttattt aaagctatac ttacacagct
    22561 taaataaaag ttttatttaa ctacatgtgc ttatttaatc aactataaat gaattatttt
    22621 taataattga caaactaaat taatgataat atactttatg tattacaaat gtaagtagaa
    22681 ggaggtatag tatgaaaaag ttaccacata tttcagaagc agaatatcaa gttatgaaaa
    22741 ttatttggaa atatgctcct atcagcacta ctgaagtaat tgaaaagttg gtagaaacaa
    22801 gtacatggag tcctaaaaca attcaaacaa tgttattgag attagttaaa aaaggagctt
    22861 taacatatga aaaaaatagc agagtattcg tttatactcc acttgttaaa gaagaagaat
    22921 acgtagctac agaaagtagt tcttttttaa atcgttttta taatggtact cttaattcta
    22981 tggtactaaa ctttttagaa aatgataaac tatctgaaga tgatattgag gaactgagag
    23041 aaatcttaaa taaaaggacg actaaggggg ataaataaat atgtatgccc cattctttat
    23101 acgattttta ctcagtacat taaccttatc aatattaatt gctgtaattt tacttgccaa
    23161 aaaagtattt aaaaaacata tttctgcaaa gtaccaatac aatattggat ttatattgct
    23221 tataatgtta ataattccat ttgtccctct taaatatatt aatcttggaa atgtatttaa
    23281 ctatttatat acttttaatc aacttggaag cagtactaat aggacttcta tgataaaaaa
    23341 tagtccaaat tctataatta ataactcaaa tgcattaaac gatttttcag tatccctaaa
    23401 ccaagttaat tttgatagtt taaatatttt attactaata tcatggataa ttggaatttt
    23461 aatcatgata gctattacta ttcattgcaa cattaaaata aaaaatatga aaaaatcaat
    23521 acaaatttta agagatgagg agatagtatt tatatttgaa aagtgtaaaa aagatattgg
    23581 tataaataag gattttatac tatgcaaatc acctattata aatacaccta ttacatttgg
    23641 atactttaaa ccacacatta tattaccaga taagtctata tctaaattat ctttaaaaga
    23701 tataaaatat atcttacttc atgaattaca acactttaaa aataaagata tactgataaa
    23761 ttatataatg tgcttccttc aaatattata ttggtttaat cctcttgtat ggtatgcatt
    23821 taaagaaatg cgtatagacc gtgaaattgc atgtgatatt tcagttttaa aaaagcttga
    23881 taaagatagt catatagaat atggacaaac tctaataaac tttgtggata atatttcaag
    23941 accatcaaat cttacactta catcagatat tggtgggtca aaaaaacaaa taaaaaagcg
    24001 actattgaag ataatggatt ttcataatga atcaaatacg ttaaaattca aaagcatttt
    24061 aatttttaca ttgatagctt taattgtatt tggaaatatt cccaaactat ctattatggc
    24121 agatatcaat gaaaaatata gacctacaaa tgaacaaact gtgtacgagg acttaagtca
    24181 gtattttaaa ggttttgatg gaagttttgt tatgtatgat ttaaaatcca agcaatatca
    24241 tatttacaat aaagaaaaaa gtaaaacaag aatttctcca aattctactt ataagattta
    24301 tagtgcctta ttgggattgg aaaatgggat aataacaaga aataattcac atatcccttg
    24361 ggatggaaag catcattcta atagttcttg gaatgaagac caagacttat tttctgctat
    24421 ggaaaactcc gtaaactggt actttcagac tctagataaa aaaacagggc taaaaaacat
    24481 acaaacttat cttaggcaaa ttggatatgg caattatgat gtttcaggtg gtatctcaaa
    24541 cttttggcta gaatcttcat taaaaatatc acctattgaa caggtagaat tacttgaaag
    24601 tttttataca aataagttta aatttgaaga taaaaatata gaaacagtaa aagattcatt
    24661 gttaatatca aaaaaggatg gggtatcact ttttggtaaa acaggcactg ccaatataaa
    24721 tggaaaagat gtaaatggtt ggtttatagg ttatgtggaa aaaaatgaaa atacttattt
    24781 ctttgctaca aatattcaaa gcaaagatta ttctaatggt agttcagcat ctaagataac
    24841 attatccata ttaaatgaca aaaaaatcta taatccttaa tatatttact gtacattcta
    24901 aaaaattcac ataattttca tattaattat caattaaatt catatacaag gcttattata
    24961 taaacataga agatagtaaa actagcttaa aaacataata taatacccta tacaaatagt
    25021 ggcaactctc cctcacatcc tcaattgttg ccactattta attttttgta tgaagttaaa
    25081 tatattttca tcatttcaac aatttgggtg caatacaatc tctattttga aacaacctct
    25141 ttaattgttt tagagtttat gaattatttc tcatacttta aaaagattga attactcttg
    25201 ataatcttct tttgtagtca ttacatatca cctactactc aacacatatt ctttgaccta
    25261 tttttacatc cttgtttata tccaaaatat ttaccttctt accatctgga aacaatacca
    25321 ttgttaaagt agactttcct aattcatgta ttctctttaa atcaacatta acaagaacat
    25381 ctccctgttt aaccatatct ccttgtttaa cagcaatatc aaagccatct ccatttaatg
    25441 caactgtatc aattccaaca tgaattaata cttctccatt agttccttta atcccaaatg
    25501 catgtccact tgaaaccact gtttctaatt tacctgaaat aggagaaaca atttttccat
    25561 ctataatatc aatagcaaaa ccatcaccta acattttttt agaaaatgtt tcatctggta
    25621 cattttctaa tgcaacaatt ttccccttag ctggagacac aaagttttca ttattttcat
    25681 taaacactaa ttcttcgtct tcatcttcat ttatagcttc tttaggcact ccaaataaac
    25741 atgttacaat aaagcagaat gcaaccacaa atattgatgc taataagtat gtgattaaat
    25801 tatatccatc atagatatac attaaataag aaggtaaaac tgctaatcca tatgaattag
    25861 attgaatatg taaaattgat aatattgctg ctcctaaacc tgaagatgca cacataataa
    25921 tcaaaggctt taaattatat cgaagctgaa tcccaaataa aacaggctca cttataccaa
    25981 aaagttgaga tagcattgct ccaactgcag tttgtttaac ttgattattt ttagattttt
    26041 tcataaatgc tagacatgtt ccaatattcg caaatccata cattgcacaa agagtaataa
    26101 gggcattaaa tcctgtattt gctaatagtg atgtttcaat cattacataa gtatgatgta
    26161 agccagtaat aacagctaat ggatatgtaa atccaataat aaatcctcca attcctaaag
    26221 gcaaatcaat caataagctg atgatatcaa ccatttttaa ttctattgta tgcattatag
    26281 ggcctacacc taacaaaata actaacattg ttattagcat aacaaaaaat ggtgtgaaaa
    26341 taaggtctaa tacattaggc atatgtttac ggaaccattt ttcaagatta gctccaataa
    26401 atgctgtaac aatagctgtt aaaacacttc cttgacaacc tacaatagga ataaatccaa
    26461 atgccataat tgcttcaatt tcatttgatg ggtcagcaac agaatatgca ttaggaagta
    26521 ttggggaaac taacataagt ccaataacaa gtccaataac aggtgttcct ccaaatactt
    26581 taaatgctga ccatacaata attgctggta aaaaagcaaa tgctgtttct gtaagaaccg
    26641 aaacaagtgt ctgaatatac aatggaatat ttgcagaaga cattccaaat aatccaagta
    26701 cattatcatt aaacaaacaa ccctttaatc ccaagaataa tcctgttgct gcaataactg
    26761 gaataatagg aacaaatata tctgctagag ttctcataac tttcttaaat ccagtttcat
    26821 tatttttaac taattcatct tgttcttttt ttgataaagt ttttaatccc attttttcaa
    26881 cttctgcata aactttatta actattcctg ttcctaaaat aatttgatac tgtccagaag
    26941 taaagaaaac ccctttaacc tcatcaactt tttcaacttt cttatcatta ataatttctc
    27001 tatctttaac catcactctt aatcttgtgg cacaatgtgt aatagaaata atattatctt
    27061 caccaataat tttaataagc tcatttgcta ttttattata tttattcatt tttctacctc
    27121 actttcaata atactgcatg aaatggtttc aaacgcactg ttttatttaa tagatttata
    27181 tcatctaaat tttggaatac aatatcatat ttttcttcta ctcttatttc tacaggttta
    27241 tcagaaaaat tataataaca atcaataact accaaatcta attgccttct atacgcaata
    27301 atatcatcac tttctatatc aataggttct attgaaccat aaatcaaaca atcagaatac
    27361 tcactatctt gtctcaactt tatcatcttt ttataaaatt ctaaaatact ctctgaattg
    27421 ttaatctgac tctgtgcatt aatatcttta taattttcaa taacctttaa ccatggtgtt
    27481 gtatctgaaa aacctgcatt ttctttatct gcccatggaa atggcgttct tgcattatct
    27541 cggcttctta aattcacaaa ttctaacgct tcttcttctg agtaaccttc atctattgaa
    27601 cgatagtatt ggtcaatgct agataaatca ttaaaatcat ttatggtatc tcttttaaaa
    27661 tttgtcattc ctaattcctg tccctgataa ataaatgggg ttcctcttaa aaagaaatac
    27721 attgctccca acatttttac tgcatcatca ttcctttcgt attgcaaaag atactttgtt
    27781 gtagctcttg gttggtcatg attttcaata aaattagctg cccatccatg ttcctgaaca
    27841 tacatttgac tatctaaaat gcattttctt aaatctggaa ttgtccatga aattctttta
    27901 aaccactcac taccagaagc aacatctaag tcagcatgtt taaagtcaaa gaccattgaa
    27961 aagaaaccat cttctccaat aaaatcacct aactggtcat agctaatacc tgctgcttca
    28021 gcaacagtca tacaatcata ttttttaaac gtattttctt ttaattcata aagcattttt
    28081 tctattccag gctgatttct aactgttttt gtacatttaa caagaccatc aacaccatca
    28141 ctttctaaac tttgaaaact taaattcttt ttgatgaatg taatagcatc aactctaaat
    28201 cctgccactc ccatttgaga ccaggtatta atcatttggt aaagttcact tcttaatatt
    28261 ggattttccc aattaaggtc aggttgtttt tttccaaaag aatgaaaata atattcgtct
    28321 ctattctcta ccttttccca aacacttcca ccaaaaacag acctccagtt atttggcaaa
    28381 tcgtttcctt ttttaaaaat ataataatca tgataaggac tttctggatt ttttaatgct
    28441 tcttgaaacc aaggatgttc atcacttgta tgattaagaa ctaaatctaa tataattttg
    28501 attcctctat ctttactttt tttaattaac tcttttaaat cttccatact tccaaattca
    28561 cttgcaatat ccaaataatc actaatatca tacccattat catccatagg tgatttaaaa
    28621 attggacata accacaatga tgtaatacct aaatctttta aataatctaa acgagaaata
    28681 attccctgta aatctccaat tccatcatta ttactatctt gaaagcttct tggataaatt
    28741 tgataaacga tttctttttg ccaccatttc ttttccataa attactcctt tttatatgat
    28801 atttcttctt tttaattctt tataaattcc attatcgaat atgtcctcac atatagatgt
    28861 cgctatatct ttaagttgtt gatgactatt tttcattgca attgtaacgt ctgatgcttg
    28921 aaacatgaca atgtcatttt gaccatcacc aaaacatatg gtttcttttt gagttactcc
    28981 taatctttct tgtaatctct taattgcttt gcccttatga aaatcttttt gaataatttc
    29041 ataatactga ctagaaatat ctctctgtgc taattccatt ttatcttgta gtatatcttt
    29101 cacttcgtca aatacctttt catttgacca taaacaaatt ttatgtatat cttgtgactt
    29161 atactcttca atgttatttt catatgttat tttttcttgg atatgttgtt tatttataca
    29221 agaattagtt cctttcaact gattcattgt ttcaaatatt tctttggctt tttgattcat
    29281 gaaaactttt tcctgactct caatcgaaaa agcaacttct ctatttttta ataaacaaac
    29341 aacttccttt atcaatcttt gattaaaaga ttgattataa agtaattcac catgatattg
    29401 aatgtaatta cctcctcctg caatatatcc atcaactcct aatgataaaa catcatcttg
    29461 tattgtaccc atacttcttc cagtacaaat aacaacactg caatgattct tttgacataa
    29521 acgtatagca tgctttgcag attctgggat tccatatacc tcatctctaa gcgtaccatc
    29581 tatatcaagt attaataatt tgtacaattt catcttcctt tcttactatc aaaatcataa
    29641 tagcattcaa aaaaaaagat atcaatattt tgatatcttt taaaaaatat gttcattttt
    29701 agcacaaatt ttcattttcg gggaatatgt tcactttcta aatacatctt gtatttaata
    29761 taaagcagtt caattaaaat aaaataaggt gttgttacat cgtagtccag ttgtttatct
    29821 acagaaatag atatagattg aatatacagg ttttcatcac ataatcttgc taaaggatta
    29881 cttatcattt ttgtaataga aaccatataa attcctttca ttctcatttc tttagcaaaa
    29941 tcaataattg tagatgcatc tccattcaat gaaataaaga aaatcatatc atctgttttt
    30001 ataaaatgat taagtgcctg aatcatatca taaccataaa catcatatat aattttccct
    30061 gttggtaaga aaatcctttt catctcttta gcaactcttt cctgagaata accttctcca
    30121 aagacgatta tacgatttgc ctttttcatt ctttcaaaca taatcgaaca atccttcttc
    30181 tctatatcat ttatcacctt attatagcaa tccattaatt ggtgtttact ttgattttta
    30241 tattctactt ctgtttcatt taagcgtata ataactctta attcactata tccaggtaat
    30301 tgtagttttt gagcaaaacg agaaagtgca cttgtagata tatggtattt gtctgcaaat
    30361 tcatctatag aaagtttaat acaatcttct ttatgattaa gaatacactc acagatatac
    30421 ttatcatttg ctgtaaatga attataatat ttattgaaaa gtccttcaat tttcattctt
    30481 ttctccttct atactctatg taattcatat gaagcaaatc taatagagca taaaatgctc
    30541 ctacgacttc ataagatata gcttgtaatg tatcaagttt ttgagtttca acatacagat
    30601 tatactcaca aagtgttgca attgtattat tatcaagcct agttaaagaa atcgtatgta
    30661 tatgattgtt gataaatttt gcaatttcaa ttcctgcttt tgtttctcca gacaaagaaa
    30721 tgataataaa taaatcactt ttttgaaatg attctctcat aaattcaatt tcacctatat
    30781 caaataagtc aataacacat ttacctactg aaagaaatat tctctttatt tcttgagcta
    30841 aacttttctg ttcattacct gtcccataaa tataaattgt ttctgcatca tatattattt
    30901 tacaaatatc ttgaaatgat attttttgta attcattcat taatagtcga taattctcgc
    30961 aaacatcatg aaaattatta tcattattaa caaattctag ttgattattt ttaagtaaat
    31021 actttaaatc agagaatgaa tctaatccaa tttttctaca aagccttaat aaagtagctc
    31081 tagaaacatt acattcattt gcaatttttt cacacgaaaa attacggtat tctctttgac
    31141 aaatcaatat ttgtttaata ataattttat cattttcatt taaattatca taattttggt
    31201 taactaacga ttctaatctc attttttcca ctccctaaat attattttaa tatacattag
    31261 ttgctttttc tagggaagag ttttaaataa taaggataaa ataatcattt gattttattt
    31321 ttattaaaat aaaaataacc tgctaaaagc aggcaccaaa aagtacttat cctttcgaac
    31381 atgtacttta gatattgctt tcttcggaag cttcatctct tcatactcta aaatagagtt
    31441 ttttctaact caaaagtatt ttccatggta gaaattactt taattcatct gccatttatt
    31501 ttttatctta tttaataatt actactactt gaatatttac ttctttaagt aaatttcata
    31561 gttaacaaag ctaaaattat tattatagat gttaaaatac aaaattgtaa gtattgttat
    31621 aaatatgctt acagctacaa atatacatga tatattaaaa agaagctgta aattattatc
    31681 atacatacaa gcaactacgc ctctattaat ccatgttaat ttttattatt taatacaagg
    31741 agttccatga gacatacata tccattcata ttttaaatta tccaattctc ttatagattt
    31801 catcatcttt ttataatccc aattccatgg attaggataa ggaactatat ttccattctt
    31861 atttttgact aaatcacctg caaataatac atcttcaaaa atcatgcaga catgccctgg
    31921 agtatgacca ggagtatgga taatttttat attcccaatc tgcatattct ctccataagg
    31981 ttcaacatcc ttaatgagcc ttctggaaat tgcctttcca ataaacttct taaacccagg
    32041 tctatccttc tctcctataa taaaaggtat atcctctaca tgagcccata cttttgctcc
    32101 tgttttttct ttcaataatt taatattaga tatatggtca acatcatgat gagttaataa
    32161 aatatgctta atatctgtaa gtttaatgcc aagtgttttt aattctttaa ttatattttt
    32221 ccccataaaa ggaagacctg tgtctataag aataatttct ttatcaaaca caataaaaca
    32281 atttgagcca cgagtactat ctaacattaa tacattttct tttatcttca taaataaatt
    32341 ccccttattt ggtattttac ctatataatt aattaataaa gttataaata gttataatac
    32401 ttgatattaa ttttattttt tattaaagta tactataggt atacaaatat tatatttaca
    32461 taaatatacc atcagtatac ttttttatca atagaaagga ataatttata tgtcagaatt
    32521 atcaaaaaga gataaagaaa aaatacaaag agaaaatgag attattgata aggcagaaaa
    32581 attattttgt cttaatggat ttgataatac aactatgaat gaattagcaa aagaagttga
    32641 atatactaaa cgcaccatat acaagtactt ttcatgtaaa gaagatttat tctttgctgt
    32701 tgtcttaaga ggatataaaa gactttggga taatgttaaa atagaaagtg caaaaggcaa
    32761 aacagggttt gaaaaaataa aactttcata ctttgctttt cataaatttt actctgtaga
    32821 accttctcta ttatgcctta tgggaatgat tggtattgta aactctgaaa aatcggatac
    32881 tgatatgctg tttaaagaaa agtttttttc ttttaataaa tttatgtttg atgaaataca
    32941 aggaatgttt gaaattggaa aaaatgatag aagtattagg catgatattg aaatacctac
    33001 tcttatgtat tcatcaatat ttacacttac aggatttttt aatttactat ctgtaacagg
    33061 aaaatcatac ctgaacaact ttaatataga tgaggaaaaa tttattgaaa caactcttgc
    33121 tcttttaata gattcaatta aagcataaac ctaagtttat aaattaaagt ttatatactt
    33181 aaatgataat tttttctatc tctaatatga aaaatattaa acataaaact aataacttag
    33241 ttaatggaat aactaaatta ctgaaaggat taaaagtaaa tggctaaaat acttctttta
    33301 gaagataatg atacaattac atttggaata aaaacttccc ttgaaaagaa aaatcacact
    33361 gtatgttgtt ataatacgat tgctgaagct aaaaaaaatt ttgataaaac tattgattta
    33421 attctgcttg atttaaatct acctgatggt attggatacg agttttgcca atatgttaaa
    33481 agtatagaag atactccagt gatatttttg acagtccgtg atgatgaaaa agacattata
    33541 cgtggattag atatgggtgc agatgactat gtggttaaac cgtttttgct ctcagtactt
    33601 caatccagaa ttaatgcagt tcttagaaga actcattcaa atactaacaa tactattaca
    33661 tgtgaaaata taagcttgaa taaggttgaa gtcaaagcat atttagataa tgttgaagta
    33721 cctttgacag caggagaata taaacttctt ctaagtctta tggaaaataa aaatagagct
    33781 atgactcgta caaagttact agaaatgctc tgggatgtag atggtaattt cgtaaatgat
    33841 aacactctta ctgttacaat aaaacgtctt agagaaaaat taaaaaatcc accttgtata
    33901 aaaacattaa gaggcatagg atatagaatg gaggacaact agtgaaaact ccaagaaata
    33961 tcaacagtac agttgttttt ataatattct gcttaattgt aactttttta ttgagtgtaa
    34021 ttctaacaac tataacttct tttaatgaat acaatgtact gtctaaggct cttggtgcat
    34081 catatgagta caatcctaag tctacagaaa gtatactaaa atcactgaaa aattctagtg
    34141 ataaggattt taaaacagga aatgaaattt tatcaaaaca tggatattct aaaagtacat
    34201 tttggagtaa aaactttttt tattttctag tgatatcgtt tggtataatt tcaacaatgg
    34261 ctacagttgt atatataatc aaacatagaa caaataagca aaaactgagt agaataaaca
    34321 atcttactca atacttagaa gaagtgaatt taggaaaaga gtctgtactt ttacgatgtg
    34381 aagatgaatt ttctcacctt gaagatgaga tatataaaac agttggggaa cttcgttgtt
    34441 caaaagaatt tgctttaaaa gaaagacaaa ctctttcaga taaccttgca gatattgctc
    34501 atcaacttaa gactccaatt acctctatgt cacttatggc acaattactt tcagaaaatt
    34561 gtccagatga agaaatagat tatattaaca gacttacaaa tcaaatctca agacttgaga
    34621 gactagtttc atctttactt acattatcaa aattggatgc aagtacttta atatttgaaa
    34681 gcaaacttat agatgtacat tctcttctta cttatgcaat tgagcctata gaaggttctt
    34741 taagagaaaa acatcagaca tttactatcg aggcttctcc ttcggtagaa tttgaaatcg
    34801 atattaattg gactttagaa gctcttttaa atattcttaa aaattgtagt gagcatatag
    34861 aagatggtgg atatatagtt gcttattata gtcaaaatcc tctatatgtt gagattatca
    34921 tagaagataa tggtaagggg tttgctcagg aagaacttcc atatattttt aatagatttt
    34981 atcgtggtaa aaatgctagt aaggacagta ttggtatagg gcttgctcta tcaaagtcta
    35041 ttatagaacg tcaaaatggt actctacatg cagaaaattg ccataatggt ggtgcaagat
    35101 tcataattaa attttacaca taaaatgctg gattataggt aaaataccta taatccagct
    35161 atatctatat tctatgttat ctattgtttt agtaatatac ttctatttac atttaaggtt
    35221 ttattaaaca aacaacttaa ctatccctat acttgtaagt agtcttaaat cgaaaccttt
    35281 aaataagttc aaatagattt tgtttatatt gtttcatttt ttatagattc tactatattt
    35341 tcattcttca actgcttgta tcctgtcata tatgatgcta ttacaataaa aagtatcaat
    35401 atagtaaaac ctattattgt agatataggt gcaaatggta aatactctat aaaatatatt
    35461 tcatttatac gtagaaaagc atacactatt cctatttgca caggaatact aagtagtaat
    35521 ggtgtaattc ctaagaataa accttccaaa ataagcatct tttttatgcc ttctggagat
    35581 aatccaacag aacgcaacat agcaaactct tgtcgtctac ttctaatatt tcctgacact
    35641 gtagcaagta catttgataa tccaatcata gccaataaac ctgtaataaa gcctactatt
    35701 aaattcatgg tctttattcc actagccttt tgtttttcac tttctaaaac atcctcaata
    35761 ctataatctc ctgaaccata gtctttatta taaatggact ctaatttttc tcttactcta
    35821 ggaatgtcct cacgattatt tactttaaat actcctatca gcctatttga acgtaaccta
    35881 cttacttcat cataattttt agatatttcc tgcaccatag acattggaac tatttgcatt
    35941 aatgtatact ttgaactagt atctactatt ttaggaagtg tgcttgtaat agctcccact
    36001 ttcatgttgt aagtataatc ccctttatct tcgtcatata ctttttcatt taatttaatg
    36061 ttatctccta ttgaaagatt taaataatct atatatactt tatttctacg tgtactacga
    36121 ttaatatctt cctccttatt atatacaatt gaggttggat tttttgtatc ataaaataac
    36181 tttgggtcta cagaaatttg cctacaatat tctgtaaaac tcttatcatc aagcccaatt
    36241 atatttgaaa ttatacgaaa cttgccatca cgttctatag gagagtactt tttagatgaa
    36301 gctatatttt taaatcctcc atttttcgca agttcttttg aagcatcttt ttcagtcaac
    36361 caagtggaag cagacatttt ttgataatat agtgaacttt ttacaccttc tgtattatct
    36421 aatttttcaa tgaaagcaga ctctacaggt tcactatttt ccaaataaac tgctatatct
    36481 ctttggtcct tataattatc acttccataa acagcttttg ctccttcttg atttgcaatt
    36541 atatgcaaaa aacatgtaag taataaaaaa gataatgtta aagatattgt tgcagtacga
    36601 taagattttt tacgagcacg tagtgcgttt gatgcaagtt ctccttctat tccaaatatc
    36661 tttcctaatg aatatttatg cgactttttg attttaacac tatctccttg tcgtattgct
    36721 tctataggag atatctttga tacttttcgt gctggtataa gtgcagaaat ccagactgtt
    36781 actattgtaa gtaaaactgc tggcagaaaa gcaggaatac cataagtaaa taccacttct
    36841 ggaacatcag tatgataatt aactgaatta acataaacta taagcctatt acacaataac
    36901 catcctaaaa ataaacctat tggtaatggt ataattgtca gtaaaaagcc ttcaaacact
    36961 acagaccttt taatttgttt tggtgatgca ccaacactag ataatatccc taattgagta
    37021 agtctagcat ttgcagacag tgaaaacgcg ttgtaaatca ccattacaaa cacggctact
    37081 gtaaaaattg ctattgtaag atacataata ggagttgaaa attttgatat actactcata
    37141 gatgctttct gttctggtga aaagactaac atctttaaaa gataattact attgtattta
    37201 agattgtatt ttccatattc attagtcttc catcccaatg atttagcaag ttttggaagt
    37261 tccttatacg tgtctcttat atttttaaat cgcaagtaca cagttatact atcattaggt
    37321 tttatacttg ttttatcaag atatccaaga gctgtatatg caggtattac tgatgaagta
    37381 gaaacatcta cctttcctac tattgtcaat gtagcctctg aaattttttt aaaactttcc
    37441 cctttcgatt ttggggctat gggttcaaga ggctttccat ttaggattct atctcctatt
    37501 gggagagtaa ttttatcacc aatttttaca cttggattat tctcaaaata ttgttttgat
    37561 aatgcaattt cattagcatt atttggtcga cgaccctcta ttatagtatc cttttctggc
    37621 atagaattcc aatactctga tgtagcattt ctataaatta tataatctct tttctcatca
    37681 ttaattttgc ctacatacca ttgtcctttt accattacat catcaactga agaaaaattt
    37741 tcaattaatg gtaagtcact tccataagta tagtcaaaca attcaccatg ccagttacct
    37801 tctttctcaa ttgaaagttt tataaaatct gtccacatgg tatacaacag tccacacaaa
    37861 gaagacatca tggttgtagt aagtaatata gctaacatta tagctatact actacgttta
    37921 ttgcgtcgta caaagtctaa ggtgtattct tgaagaatat tcatttcttc accacctttt
    37981 cagagacaat cactccatct tccatagtta caatacgatt tgcctctagt gctattttct
    38041 catcatgagt aataagaagt attgtctgat taaatcgttt atttgataag tttaacaagt
    38101 ctacaatttc ttctgaattt tttctatcaa gattaccagt tggctcatct gctaataaaa
    38161 tagctggtct atagattaaa cttctagcta tagataccct ttgttgttgt ccacctgaaa
    38221 gttgacttgg aagatggttt aatctatcag ataatcccaa tatagataca atctcagaga
    38281 atctatcctc atccaccttt cttttatcaa gtaacatggg taataatata ttttttctaa
    38341 catcaagggt aggtataaga ttataaaatt gataaataag acctactttt ctacgtctaa
    38401 aaactgcaag agcttcttcc tttaaacttg atatttctgt atcttcaaca taaatctttc
    38461 cagatgtagg tctatctact cccccaagca gatgtaacaa tgtagatttg ccagaaccag
    38521 atgctcctac aatggataca aaatcacctt tttgaactga taaatttaca ttattaaggg
    38581 ctgtcactct ggtttgattt gaaccatata tttttgtgag attttcacat tttaatattt
    38641 ccatatacaa tcatctcctt tatggttaaa ttttagcaac ctaaaatgac attatagtga
    38701 catgaataca aatataaatt actattaaaa atattgttta gtttttgcac attatttaaa
    38761 attataatat aaaacaaaaa ctatgcaata tattttattt atacttttaa tatattacat
    38821 agtctttaaa aggtattaac tttaaatcta taggtattca atttaataat caatagcaag
    38881 tattttatgt actaaaggag ttttgctcta tatagactca atttagtaaa attatttaat
    38941 aaatattaca gactataggt aaataatatt tacaaataaa attaagttta ttcccttaca
    39001 ctataatatt tcttaattat attaattgca atttccttta cctttggccc tgtaatttct
    39061 ttattggaat catctgattt aatagcaaaa taataggtgt caccttcacg ctctagcata
    39121 ccaacaaacc atgcatccac acgtttattt ttttcatcaa atcctgttcc agtttttcca
    39181 tatacattta tgtttttatc atttacatct attttcataa tatctcttaa aatattaata
    39241 tgctcttttt taaagtttgt atctccctca aatatttttg ccattgtttg cacttgttct
    39301 tttggagata tttgtaatga agattctaac caaaatccat ttaaatgtcc ctttccattt
    39361 tttaaatctc cttcccattc gctaatatcg caattcccat actttaaatc atctaaaatg
    39421 ttttggacag atttagcatc aactttatct atcaattttt tgtagtacca aacacaagac
    39481 tccttaaatg cctcttctaa actaagattt ttattccaat ttttatttgg atactctgta
    39541 ccatcatatc ccataactga ttcttttgag tttattaccc ctttttctaa accaattaaa
    39601 gttgaaacta ttttaaaagt agaacatggt gaccttcttg tttcaattaa ttctttgtta
    39661 tatatattat attctttatt tttagtatta taaaaaatag ctcctccact aataccttca
    39721 aaacaatcac tatagtcaac catattaatt ttttcttttt tgtttttatt attgttttca
    39781 attttggatt tatttaattc agacttattt aattcagatt ttatataatt cttatcagtt
    39841 ttttgattta tatcgttatg ttttttccct acataataca ttaccataac tacaccaacc
    39901 aataagatag ctatccaaat aaaattcttt tttcttttca taatttatat catctcccat
    39961 atttaaattt ataacctact attaaaatag tagacattat ttgtaatata ctccaatcta
    40021 ggttctactt ataagaaaca agactaaatg aatagctgta tctcttatat tttcttcacc
    40081 tagtacaatt atgttgatta aacctattgc gaagataatt aagtaactat taataacatc
    40141 ctgtcctcct tttaatttgt gatataataa ttgattccac atttaaaact tactattgta
    40201 atatttaaat attacaatag taagttttaa atgtcaagtt agtttgggaa agttatttta
    40261 attgtataat tgttattaca tttataaaat atggcatgtt taaaattatt ttgctattgg
    40321 gaggattaag ataagcagta ttataaaagc tataaattat aaaatttaat atataattta
    40381 tagcttttac ttttacaaat attgttttta ttgatttatt aatgaatttt attgacaggt
    40441 tatatttata taagtaaaca cttacataat aagtatataa tctacatatc tataagttga
    40501 gtcaattcac cagtatatgt caacttaagt ttatgcatag ctcgtgtaca agcaatatat
    40561 aacaaactgc ggtcataatc actataatat gttttattat ttactgaagg tacaataact
    40621 tcatcaaact ctaaaccttt tgacatttta atagaagtta tggatactcc ttttgtaaag
    40681 ctagaacttt cagaagatat taagtgaaca ctatattttt ctcttaacgc atcatataca
    40741 gctttagcgt cattatctgt ctttaatata ataccaagag tcgcattatc actcttttta
    40801 aattcttcaa tttctatttt tatcttattt atttcatctt gctcgttatt acattttaat
    40861 aaagctggtt cttcaccatg tcgttcaata ggctctaatg aagatatgtc ttgaatcttt
    40921 ttggcgaaat taataatctc aaaagtagaa cggtaactct tattcaacat aactagttcc
    40981 ccatcattat atagctgttt catatcatct agtgtatgag tgtgattagg attaaccaat
    41041 tgtccaaaat ctccaagaat agtcttttta cacttaaaaa gtaagtttat tacagcatat
    41101 tgaataggtg tgtaatcctg catttcatca ataacaacat gtcttataat cttatcttct
    41161 tgtatacctt catatgcagc atgaatatat ataaatgggt atacatctga ccattcaaga
    41221 gttttttttg ttgccatcac aaacatgttt gatatattca tttgtttaaa gaaatcctta
    41281 tatagtgtaa gagtattttt tattgtcaac attccattca aacttttaag tatacttttt
    41341 acctttggta aatcttcttc cataatatta tctgattcaa atttataatg aatgtcttca
    41401 gctaccttct ctaatctctt cttaactgga tatctgttat atgcctcaaa tctactctgt
    41461 atccagtcac ttttagctgt aaaacttcca aaagtgtagt cttttggaat aaaaatctta
    41521 tttggcattt gttttatata atcatcaata agttttacaa aatcaagtgt agatttaaaa
    41581 cgcactcttt cagaccattt agcatcattt atttctaatg ggtctttctc actttcaaaa
    41641 ttaataactc tatctaattg tacctctgct atattttcaa aacttaattc acataatggc
    41701 tcttctccaa gctcaggaag gacattggaa atatagtctc caaagacttt attaggtgat
    41761 aggataatta cattatttgc tgatatttta tctttaaatc gataaagaag aaaagcaatt
    41821 ctgtgtaatg ctatagatgt tttcccagaa ccagctaccc cttgaataat cagtgtatca
    41881 gctttatcat ttctaataat ttgattttgt tccttttgta ttgttgaaat gattgacttc
    41941 attttttcat ctgaagtgtg actaagttct ttttgaagaa tatcatcttg tatattaatg
    42001 gaactttcta gtgcatattc taattttcca tttttaattt taaattgtcg ttttcttgtt
    42061 atttctccat ccacccatcc tattggagca tcatatccag cttttccgat ttcataatca
    42121 taaaacatac tggcaattgg agaacgccag tcaagtatta taagctcatc ttcataatca
    42181 aatgcaaatc taccaatata atacttagat tcatcatcca tatctttcag cctaaaatct
    42241 attctagcaa agtatggaga atctttgatt ttattaatct tatctcgaac ttttaccata
    42301 aaagccccat agttatctat ttgttttagt ccttgttcat tttgaaacat ttcatgtggg
    42361 tctatttcac cacgattttt taccatatac attttagcgt ccatataatc cttatcaagc
    42421 ttgtcaacaa gattttcagc tttcttaaaa gcattgtcta gcttgttatt tatctctatt
    42481 agatgtgcaa tctcatctgg aaaaaaagtt aataactctg catcatattc acacatatta
    42541 tgtttagaat tagatgcaat aatatcgcaa tttactactt gtttattttc agacatttaa
    42601 atcctccttt gttaattaag tacttacact gaatcattat acttaattgt gttttggagt
    42661 ttttaatcat tcttgctatt taacttaaat gttagctttt tagctttaaa gttccttttt
    42721 taaaaaacta aatctttcta tatttattac cataagtaca cttacaagca aaatacatta
    42781 aaagcagaaa tgctcttata tataaaataa ttcaaacaaa aaatatgtgg taaacttttc
    42841 atttaatcta caattaattt tgtctattat ctctttcttc tacacaagga agaataaatt
    42901 tttgagtagg atatccaaat tccacaagca attctgcttc tgcaaagccc aacttcttta
    42961 tcatatctct atgtcctgta tcagctttgt caccctctcg aaaggtagta attgaaatat
    43021 ctgtatctat caagaaatct tcaataactt tcttcaaaaa cacttgtgca atgtctgaat
    43081 tacgatactg tggatgtatt ccaaaaaaat caatacttct agtttctcta ttaaacacca
    43141 tatttgcaat agcgacatta ttaagtttta atattaaagc tctttcttct aaaatatact
    43201 gttctaattg atatatatat tcttcctctt gcaaatttgg aaatccatct atgactaatc
    43261 tcactaaatt catccataat ggtatgtcag acatacttgc aagtttaatt tctttttcca
    43321 actctagtac attctttgaa aataggttat cttttttcaa aacaaatctt agctgcaaag
    43381 gataaaattc ttgttctttc ctatatttat ttggagattt tttatacata gctttaaata
    43441 tagaagtgaa tgcctgttga ctttcatatc cagctatcaa tgcaatttca ataattggtt
    43501 tctttgaaaa taccaataat tttgctgctt ctgtcaactt tctccgcttt atgtaatcat
    43561 gcattgttag accaacagaa gttgtgaaag ttctatgcag gtgatatttt gagtaatgaa
    43621 cagcattagc aactatatct aaatccagct tttctgataa atgctcctct atatagtcaa
    43681 tagcagttat gacattaatt actttgtaag acattgcagc ttccctcctt ttatccatgc
    43741 aacattatat caattattac ttagttatat ttaatgaatc ttgctatttt ataaacaaat
    43801 ttgttgttta agttttcaat tcataaattt aatatattac tttttacttt ctgattaaag
    43861 actctaatcc tttaattttc aataactttt catttagtaa atctaaaaag ttatttatta
    43921 ttttcttctt attagattcc ttttatattc cttaattaaa tgataaatat ttatattata
    43981 cgactaaaaa cagcttttta caattattta atatgattac aaacttaccc tatcttaaag
    44041 tttaatgggg tcctgttatg aatcttttta ttttaattta agctcttcat cagtttattt
    44101 tatatattga tgtatttgat ttcatacaaa aaagagtgct tcatgaacta aaaagttcat
    44161 ttttaaacac tctcttttat gtaaataaat ttctattcta ttttgaaata ttataatttg
    44221 acttataatc tgttaatacc aaaaataata aattgtacgt ctaagaatag attctaatta
    44281 gttgctcagt agtaaaatct gtttttaact aatcctgctt tgtatgttga acatattcta
    44341 taattgtacc atctggatgt ctcaatgtca tattatatcc tgtaggaact tttttcttat
    44401 ctcttactac aactgctcca ttatccaata gataacttct ccattcatca acagaatcaa
    44461 ccataaaagt agattttgtt tctataaatg gtttaagagc atcatcagaa ccagataata
    44521 gtaaaacatt tcctatttgc gctaattcca acccaacttc tttataggaa aaacgcaaag
    44581 aacatttttc ttttaaaaga ttttcataaa aaggtatggc tttttctata tcttgaatat
    44641 aaaaacgtgt taatatatca tatattttca tattttcccc ctatatatct atataatatt
    44701 acctctaaat tataccactc tacaaattat ataacaataa attaagcata gccttttgag
    44761 catcttaagt agaccttaac aatatattgg ggttacatta gaatacataa attaaatcac
    44821 cttgatatta tttaggataa aatttatgta gtagcagtaa atgttcttct aattatcaac
    44881 taacaaacga taatctttaa ctttctatat aatgggtaac atcattttcg taagatattc
    44941 actagctgga cgattgatat catttaaata ctggtaatat atatcgccat gaagtttata
    45001 tccattgcta tttgcccatg aaaataagtc ttctaaagta gggtcttgta attcataagg
    45061 tcctaaatca attgcagtta ttattttctg tgcaggaaca atcctttgta gaatctcatt
    45121 tttcccatct atataagtgg ctacaggaaa ccctacttca acatccaatt ttgctaaatc
    45181 catgttatga aaacatacaa tcggtgctcc tgaagataaa attcctctct cctccagata
    45241 tttagaaatt ttttcaaaac tttgttttga aaactctgaa aactctacca taaagtcaat
    45301 tgtttttcgt attgccaaaa aacagtactc agattgttca gctattgtta tattggatat
    45361 tctagtcatt ttattcctcc attactttat tttcatttct aatcttttta taccaaatta
    45421 tacgaaaatt tactgtgtaa ctaattattt catatgaata taaaacataa cctccttcca
    45481 tttcttatat cgaaagtata gcaaaaataa tctcatcatt cttgtcacac agtgctctta
    45541 taatcagaac atacttaaaa gacttgccta atttttaggc aagtctaaaa gaaatctttt
    45601 tctataaaaa atttatacaa acaattaaaa gatcaaaata tagactaata taaaactata
    45661 aatttactaa tctgaacctc ccatggctaa agtcacaaga ttactgattt atagaatttc
    45721 gcacactaaa atatgtctta ctaattcccc acaggctacc cccctagttc ctacgttctt
    45781 acataagtta tctattatca aacatcaaaa tttaaacaag tttcaggttc atcttctatt
    45841 cttgctattt taaacttaca tgcaattaat actaaagata ctattggatt tataatattt
    45901 aataaagcgt atggaccata tgttagtgca gatacaccta atgttgctgt tatatacgcc
    45961 ccgcatgtat tccatggtac taatggagag gttaaagttc cactatcttc taaagctctc
    46021 gacaacatct taggatgtat acctctcttt ttatattcct tattatacat tcttcctggt
    46081 ataactatag atagatattg ttcacctgct attatattgg taattgtaca agttaccata
    46141 gtacataata ctgttccaaa tacacccttt gctaatctta gtaaagaaga tgctactact
    46201 tcaagcatac ctgttttttc taaaatacct ccaagagata aagcgcatat tgttaaggat
    46261 acagtggaca tcatattcat aatcccacct ttagataata aagcatctac ctcctgtatt
    46321 tgtgttgacg aaacatatcc attttgtgct gcatctaata tcgtattcat agattctcct
    46381 tgaaaaacta ctgcaaacaa tactcccaat acagcaccta ctataagccc tggtatagca
    46441 ggaactttaa atacaaccaa tccaattact attgctggag ctaataataa tactggtgat
    46501 aaagtattaa atgtagaatc taatgtagac ctaattaatt ctatttgttt tatatctagt
    46561 gcttgacctg aatacttcat tccaattaca ccataaatta ctaaacaaat taataatgat
    46621 ggtatagtcg aatatagcat atattttata tgtgtaaaca aatctgttcc tgccattgct
    46681 ggagctaagt tagtcgtttc agataaaggt gatagtttat ctccaaagta agctccagat
    46741 attatagaac ctacgattaa tccaattggc atacctaaac tttgaccaat gcctaaaaga
    46801 gctactccta ctgtacccat tgtgctccaa gatgaacctg tcgcaagaga tactattgca
    46861 cagactaatg ttgatgctac taaaaaaata tttggtgata aaatttttag tccccagtaa
    46921 atcatacatg gaactactcc acttactatc caagttccta taagtacgcc tattataatt
    46981 atgattaaga ttgcttgcat tgccatcttt atactattaa acatacttaa ttctaactct
    47041 ttccatttaa atccaagtct atatacagcc acaagtcctg ctactgctgc tgctcctatt
    47101 agtggtacat gaggtgatga accatacact aatactccta gacttaaaaa taatatcaaa
    47161 caagtaattg gtatcattgc atcaaacaga cttgcttttc tacattctcg ctctttcata
    47221 aaatagtttc ctcctaatta tttaaacact acactataat tttttttgaa acatatttgc
    47281 tcgtactaga tgacatgata cccccataag ttaataaaaa ttctaaattg tcacctaatt
    47341 tataatcata ttttgtgtta cttacatcta gtatcatgtg gtctgaactt gcccctaata
    47401 tttttatatc agtgtctatt ggaattaaag agtcaatatt tatatcttgt ttacctatag
    47461 ctatgattgc cctttttaag attcccttat cttcataaac aggtttattt ctaaaggcat
    47521 caactcctat ttctccaata ggaactgatg gtttttcttt acattcaact acttggcata
    47581 ttaatttaaa tgcatcttga tatgttccat ttatattttc accgtatgcc gtttctctac
    47641 caagtagaat ggactcgcct attctcaaat tagtaatacc ttctggcata ttattattta
    47701 tcaacagatg aatagaactt gaattacctc cagatactat ttctagattt attccaaatt
    47761 tttcttccat tctttttgct atacttacca gtctgcctat attttcccta gatggtataa
    47821 tagctccata acaggttaag tttgtagcta taccaattat ttcaatattt tttaatctta
    47881 ctatctctct tacattacta aaaaagtctt cttcataaaa gtatccttct cgtaaatcgc
    47941 ctaagtcaaa cataagaact atcttatgaa taatattttt actttcacat aattcattta
    48001 atttctttat tgttcctaat tctgagttaa aactaatatc gcaataattg ataacttctt
    48061 ctaattcact taacattggg attctaatca atatcttagg tagatttata tcttgtaaat
    48121 tttttaagtt ttgtattctt gaatctgcta tatggtctat tccttcacta catatttctt
    48181 ctactatttc tttttgtgca caaaatgatt tagtaacaaa agatatctta atatttcttt
    48241 catgacacat ctgcgaaatt aattttgcat tatgctttaa cttttctata tctatttcta
    48301 acctaggata cataatcttt cctcctcaaa attcaaactt tttaacagga gcttaagaga
    48361 tgcttcttca tattttttag ataaaacacc catagatgcc ataatatagt cattatctat
    48421 taatatcttt gttttttcct ttggaaatag taattcatta tttttattgt atttgagcat
    48481 attatctaat atttcaattc tactagggag cctagtaagt gctccccctg taccaactat
    48541 atatcttact tctgttaaat ctttcccttc tgcaattttg acttttccag ttgttccata
    48601 gatatttctt atttttcctg aatgtcttag catagcttta acaacagctt cttttgtcaa
    48661 cctctcaaca aataatattt cttcttttga ttttggtatt ggaggataat tctctattac
    48721 tgcatcaata tctatagata gttcactttg taagttttct ttacctataa cttctactat
    48781 attcttcata tttacatata cacctaaatc cccctcaaca cttctctttg cagtaggttc
    48841 aggattaacc aaaattttat taatatagtc acttccatct gtaacagaat gtacatcagt
    48901 agttgctcca cctacatcca gagttaataa atctccaata tttttatata aaagtttaga
    48961 agcttccatt acagctcctg gggttggagt aatattttca ttaaccattt ctttaatgta
    49021 tttcattcct ggtgctgtag ttatgtgttc ttcaaataca ctttgaatga ttcttcttgt
    49081 aggttctata ttcaataaat ctattttagg gtatacattt tcagttatat aaagcttata
    49141 attagtatct tcaaatatta accttatttc ctcttgattt tcaacattac cagcatatat
    49201 aactggtatg cctagattca tagaagctat catttctgca ttataaatag ctgtatctct
    49261 ttctccataa tcgactccac cagctattaa aattatgttt gggtttattt cttttatttt
    49321 atttaaatca gttcttttaa ttctacctga tgttatttga cgaataacag ctccagcccc
    49381 taaagctgct tctttagctg cttttactgt catatcatag actaatccat gaacagtcat
    49441 ttttaatcca ccagctgcac tagaagttgc aaacatatca ttatactcta tatcatctac
    49501 agataattta ttagctaaat ctttaatagc acctgataag ccatttctta catcgccacc
    49561 ttcaaacact gttgttggag cttgaccttg acccaaaaat ataggattgt tagtattaat
    49621 atcgtggaaa gcatttacca ctgtagtagt acttccaatt tcagctacca acacatctat
    49681 ttttaaagaa accttgctat tttccattat ttattactca tttctcttct tttttcaact
    49741 aagaaagtgg ctacatgtat gcctttactg tttcttccaa atccagcatc tatgccttgt
    49801 tcaacagcta tttcaggtgt tacttgtgtt cctccacacg caatcattac tttatctctt
    49861 ataccttttt ctacacaata atcgtgtaat tttttcatgt ttttatagtg aatatcatca
    49921 tgacttatta ttgtagatgc aagtattgca tctgcattca gttcaatcgc tgcatctacc
    49981 aatttttcta caggtacaga agtccctaga tagtggcatt ctatgccata tttttcaata
    50041 cctccatgtt ttatatctat tatttctctt aaaccaactg aatgttcatc ttctccaacc
    50101 gtagctgaaa ctattttcat aggtttttct tctatatctg ctcttatttc ttcatcagtt
    50161 agtaccttag gttcttctgg tattactaaa ttgtttaaat ctatatcaaa cggaactctt
    50221 cctttcactt ctattctagt cccttcagat tcatgcataa cttctctact tatgacctca
    50281 atttcttgta agttcatttt tttgacaaat tccaaagctg caaactctgc tgttctttta
    50341 tcagtaggaa gcatcattgt tatcattaca attccatctg cacaccattc catttcaggc
    50401 ttaattttag ttccatttct gtactcatat gattctttta gtctattttc tacattatca
    50461 aaatcgtcaa gctcatcaat atatattatt ttgtctggat tttcaaatgt acatccatct
    50521 attaacattg atggattatc tatagcattt tcatcatatt gagctacatt attgtatcca
    50581 aagtgagcag ttacaggtgc taaataatct tcttctcttt cataaacagt accttcacca
    50641 actccacctt ttatttttct agatattcca tcaccatttc tttctggata atttccagaa
    50701 tcaacaaaaa atccttgttc cacagattca aaatatccac caacttcaga tatttcttcc
    50761 atatataata cagctctttc tttaagttct cttgctttgt ctcttaattc acccacatct
    50821 ttaagttcta tcatatccat aagcccatcc ataccaacta aagcttgctt tgctgtatca
    50881 catgcttcta tattgtatat atgccaaggt acatttctac cttcatcagg tgttatagtt
    50941 gattgtatgt cagctctagt taatactgat gttaataagt ttaatacatg agtaactgtt
    51001 gcttctctag ttgatgattc catatattta gtattcattt gagctctcat cttataatca
    51061 ctaaataact ctctaagtgc aacagcgtaa ggtaagtcta tttttaaaca tggtgctgga
    51121 ggtgctgttg gtggaactgt tgataagcat atattacttt tatctatacc tattttttct
    51181 gaaaatatag agtttaaagc gtgttgaacc ataagttcag gcattacctt ccatgcttct
    51241 ctagcagtag cattagcatt atgtgctcca tcaatttgag ctatattggc aaaagccatt
    51301 attttctttg cctcacaagc atctacaaaa gaccttacca tgtttatatt cctatacaga
    51361 acattatatt gtgggtcttg atgtgctcca ttgactcctt cctcagcaaa cattactgct
    51421 acttcaggac cagcaacacc acttacatat gaatggtaat taataggtct accaacttct
    51481 tcttctataa aatcaagagc cttcctttga gctcttactt gttttcttgt tattggaact
    51541 ccacctatac cttgtggagt tccttctata agcccatcaa aatgtgattg tccagcagtt
    51601 ctgataacca ttagatggtc agctccatga tgagctgcca ttctcattct tcttatatca
    51661 tcctcaaatc taccagaagc tatttcagta gtaataactg gacttggttg agggtctata
    51721 ttattgaaat acttagatga tggtagccct acactcttct ttaaaggttt tgtacagtct
    51781 ttatatttaa aaggtcccat ttcaagattt tccaagtgtt ctctccaaac ccaacctctt
    51841 cgttttggtt tatatttatc caaatctttt aatatatagt ctatatccaa ttttttattt
    51901 tcctttaaca tgattctacc ccttctctaa ataaacatgt aacttcatcc caatattcac
    51961 ccttaactaa taacaaacct gcttctctaa ccgttatatt tttagattta gccaatttat
    52021 aaactacatg ccctgctcct ttacctataa gacctctttc cataacccct tctaaaatag
    52081 gttttacttc aagagaagaa aatcccattc tcaacaagac agacctttct attgatggtg
    52141 ttgtattctt tttaccaagt tctatcattg gttctactat ctgggtagct aaactccaaa
    52201 acctttcttt taactcatca tcactcagtt cttgaagatg ttttcttcta acttcaaaat
    52261 catcctctct ttttttcatg aacattcctc cattcgtatt gatttaatcg aattttctga
    52321 atttttattt tatattaaat taaaaaacaa taattactat aaattattta atacatcaac
    52381 aacaaaatct cttgaacttt ttacttcttc cattaaaaat tctatatctc gattacttag
    52441 cttatcaata ttatcaatgt gattattaga tatacaattt tttataaatg actttcttat
    52501 tttattcata tcaatatcaa cacatttcaa taattctggt ctttctggta atattaagtt
    52561 tactcctgca atttcttctc ttggatttcc aaattttata tctattccat tttctcttgc
    52621 aaaagtaagc tgtggacata tatgtttacc tgcgcctgta tattctgttt cttgtaccac
    52681 tataacttta tcctcatcta actcttgagc taaagagaat gctgctgcta aagatgtatt
    52741 tcctgctgga cctctttcta taccttctag ctgtgccaat aattcagttg tataaaaaac
    52801 ttctccttgt tttactaata catatctatc catatatcta agtggtctag ctgcagacct
    52861 aggtacatct gacctatcag gccatgtaca gtatggtatc ccaaaacctg tatgtcctgt
    52921 tgtaaatgat tttttattaa attgattatc actagccatg tgtaatcctt ttaaatctac
    52981 acttgctcct actactttag tattaataga accagctttt atcaatcctc ttgcagttcc
    53041 agtaagatta ccaccacctg catttgtaca aacaactata tcagggtctt ttttatactt
    53101 ttctctaaat tggatagcta actcataacc taaagtttct acacctgcaa ttccaaatgg
    53161 tgaatataat gatgcgttaa aatagcctgt ttcttctaat aaaactaaga acgtataaaa
    53221 taactctggt ccaacagtta actgaacaac ttctgctcca tatgcctcac attttcgtgc
    53281 tttttctata atttcaggtt gacctacacc attagaatca taacattctt gaactattat
    53341 acattttaat ccctgcattg ccgcttgtga tgctacagct gcaccatagt taccactagt
    53401 agctgctatt acacctttat atcccatttg tttggcatga tatactgcag tagctgctct
    53461 tcttgcttta aaactaccag atgcattcat tgcttcatct tttacaaata ttctagctcc
    53521 tttaccttct ttagcacatt ttctagctaa tttagtcaaa tttttaagct ctattaaagg
    53581 agtatttcca acagcatact gtgattgaat tgcttcaata tcttgtaatg tatatcctgt
    53641 ttcactcatc attttctcat aatcaaaccc tattccctct tgttcaaaat aagaataatc
    53701 caatccgatt gcatttttca ttatttcgtt atttcttccc ataacagctt gataactcat
    53761 atctttcatt gatgttgaat tattcattat atacacctcc aaataatatt tctttagctt
    53821 ggattcctat ttggagtaac tctggtatac atttaccata atcatgagta taatatggat
    53881 ttattttaag taaattacct tttacaagtc tgcctgtaat tgttttaact tctactaagt
    53941 cgcctataga agcatcactt tgtataaaac ctttaaccca catttctaag gatactttct
    54001 tagtatcctc tggaacttgt ggagctcttt cttctggagt caatactata ttgtgtataa
    54061 taacccaatc attaatttta gcatccattt tttcatcccc ttattaattg actattgcct
    54121 tactaattaa tttactgtta ttttaaatta aacattattt taccaattag ctaactgtta
    54181 tcttactaat tagctagttg ctatcttact aattagttag ctgttatctt actaattagc
    54241 ctttgattct tcttccaatt caacttctat ctgatttctt atatctccca ttattgctct
    54301 aggtactggt atatccaaca tagttttaag acctggtcta gcatttatta ttaatggaat
    54361 agagtttact atcattgcat aagtacctac tcctccaggt atttcaggat ttatttgtaa
    54421 atcaatgttt ggtatacctt ttattgatac atagtctcct gttttaatac cttctgcttc
    54481 tggtattatc tgttgtggat gctccatttc aattaaaact tctccattta catatccata
    54541 tccacattgt ctacaaccag caacatttcc agccaatgcc tctccgtact tagattttct
    54601 atctactata gtcattattg gctcttttgt ttgttctatc ttatctaatt tccaacctaa
    54661 tccatcagct atcatattta ttgattctac aaaacctaca tgacctgcta tagtcttatc
    54721 ttctacacct tttataaatt cttcccttgt tactccaaca ccttgttcct ccataacaga
    54781 ctttccaaat ggagataaat catttactct cttagctttt atactagtaa cttcttcaca
    54841 agtgcctgaa agcgccaata ctagtaaatc taatacaaat cctggattta ttcctgttcc
    54901 aagtatactt actccatttt cctttgcaac ttcatccatt tttttagcta aatctgcatc
    54961 atcagcttgt ggatatgcca tttgttctgc tgttgatata acatttattt ttctatttaa
    55021 taagaaaatt attttatcaa aagccttttt agtaaatgaa tcagttgcta acaaaacaac
    55081 atctacactt ttttctctaa aaacttcttc ataattttta ttgataataa cttctggtct
    55141 ttctcctctt tcaattccta aaacattata catacttttt cctgaagtac ttctactaca
    55201 aacagatact atttctatac cttctttctt tagaatcata ttagccatac ctattcccat
    55261 agctccaaat ccccatattc ctactcttac ttttctcata tatacaccct cctaaaaatt
    55321 tatatattct caataattag ttaaagcata aatcgtgcca actttaaaat taaagtaaat
    55381 atttattgaa acgttgaaac tataattatt ttattatgta ttttcataaa taaaaaataa
    55441 tatttcttat gagaaataaa aaaaagagca aaatattttg ctcttttata ataattttgc
    55501 tcctctattt tgctttttta ttttactttg attttgtttt tttatcttgc ttatttataa
    55561 tattttgata ttatattttt ttattttata ctgtaaattt tgcctattca tacctaaaat
    55621 tgatgcagct ttagttatat tgtaagatgc cttttctaat gattcatata tatacttttc
    55681 ttctatctca ctgataatct tactaagtgt tttgtcctcc aaatcgttta aagaataatt
    55741 gttactctct ttattctctt taagattgta atagtcgttt agattaatca tacttgtttc
    55801 tatttgtacc tcatcttcca tcatactcat agtacaataa attatgtttt ctagctctct
    55861 tatgttacct tgccaatcgt aattttttaa aattttaata gcttcatctg aaattcctac
    55921 tactttttta tttaactttt tattatactt tgaaataaat tttttgcaca atagaggtat
    55981 gtcctctttt ctatctctaa gaggaggaat ttttatatga attatgttaa gcctataata
    56041 taaatctttt cgcattttat gctcgtttaa aattaccttt ggactttcat ttgtcgttgc
    56101 aataattctt acatctatag gtatatcctt agttcctcca acccttctta cataaccttc
    56161 ttgtaaaacc cttaatagtt tagcctgtaa cataataggc atggaattta tctcatccaa
    56221 taacaatgtc cctttgttag cttgttcaaa taagcctggc ctatctattg ctcctgtaaa
    56281 tcctcccttg ctagttccaa aaagaatacc ttcgaatagt gattccggca aagctgcaca
    56341 attttgtgct ataaatggat agtttttcct attacttcca tagtgaatgg actggctaaa
    56401 taactcttta cccgttccag tttcaccgta tataaatact gaagcatcag acttgcaagc
    56461 tttcttagat ttagctattg cttctttaat caaattactt tcccctaaaa tatcatcaaa
    56521 ttcataaccc tttttttgtc taatactaac tttattgact aaattttttt tataatttct
    56581 gtttagtaaa ttttctatcg ttgtcatatt ctttgatatc tcaagtgccc ctacaaactc
    56641 gcctttaata tcaattggta ttgtagtatt aattgctgtt atctctcttc catttttatc
    56701 cagatatttt tgaatattgt ctttgataac ttcccttttt tccaaaactt ctaatagtgt
    56761 actcctgttt attttcattt tgttgactat atcaaaaaat gaattggtta aaatatcgtg
    56821 tctgttcatt ttttccattt tttgtacaga attattgtag attatagttt tcccgtcttt
    56881 attaacaaaa tgtacccctt catcaatatt ttccaatatt tcattcatta ttttaaaaaa
    56941 tatctcttgg ttcaactata tcaccccagt acctaaatat ataaaaaccc aaaaaattaa
    57001 taaaatgttg ctattgtatt tatcttatca tatatttatg atatttttta tgtac
//
LOCUS       DAEHWM010000014        56950 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.015, whole genome shotgun sequence.
ACCESSION   DAEHWM010000014 DAEHWM010000000
VERSION     DAEHWM010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 56950)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 56950)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..56950
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.015"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(275..1876)
                     /locus_tag="KNP36_000897"
     CDS             complement(275..1876)
                     /locus_tag="KNP36_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBF0872786.1"
                     /translation="MIYDLILKNGFIIDGTGNPGFYGDIAIKDNLIAKIDSKINSNTN
                     KEIDCYGKIITPGFIDPHVHEEIVAILDGKFEKFLKQGVTTTINGNCGHSITPYSSEN
                     VYEYMYKNGLLLEEEKKYLIDKNKCWNNFTEYCDLISKSGISVNMGFLLGHGTIRWSV
                     MGGSKDRPPTEKEKNEITDIINDGMKSGAFGISTGLAYIPSKYADIDELVDIARQIKE
                     HDGIYTSHIRDYIGRYNAVKEAIEVGQKSGARVQVSHLSPVEIEAFDEILKARYNGVE
                     IMVDTVPRSSGHCMKKKRVIQFIMAISSSLFELGIDGVMDALRNEEGRTLILKEAFIL
                     GDRGSIILLNTKDINMEKKSIREIATQKGIDEDKLLLDLLLDGDEELIFCLGGMYRAD
                     FPDKLHDDKIIDNPFVMVGSDCLFSVGGDMSWFELQRRGAFPIFFNMYRKSGVRLEEI
                     VRRVTSLPARQFKIKNRGILKEGLIADIAVIDMDNYSYPRSEDIDFSKPQLLANGVEY
                     VIVNGKIALENGEITENKCGEVLKR"
     gene            complement(1987..2664)
                     /locus_tag="KNP36_000898"
     CDS             complement(1987..2664)
                     /locus_tag="KNP36_000898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872787.1"
                     /translation="MSKVKSIYNEEYLPFMIRYGRLTLSLGIIAALVPGIILSFGFGI
                     MPPISALLASTMAIVSMSAPNYIIEPVSYSPILGIPGTYMSFLSGNISNMRLPCSIAA
                     QKAAEVESGTEEGSIISTIGIAVSILVNISILTIGVILGGSVLSKIPAEVVEKLNLIL
                     PALFGSVFGQVFLQDKKLGLVAIVISVLTIILSKQGIIPQSLVVLICVFGTILIARAM
                     YKDKLSD"
     gene            complement(2677..3372)
                     /locus_tag="KNP36_000899"
     CDS             complement(2677..3372)
                     /locus_tag="KNP36_000899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5058 family protein"
                     /protein_id="HBF0872788.1"
                     /translation="MDYLKLANHPLLWIASTVAVSIVVVQSLIFAIKSCKVGKTMGIT
                     DKQIKSAVKSSAISAIGPSMTIFAGMVSLIVTMGGPIAWMRLSFIGSVIFESMSAGFG
                     TDALGITLGSPEMTKLAFTNAVWTMILGSLGWIIFTLLFGHKLDKITNVISSGKKSFI
                     PIISLGAMLGSFAYLNADRVLRFDNGTIACISGMAIMVILCMLEKKKNIKWLREWGLT
                     ISMFSGMIIASVI"
     gene            complement(3424..4623)
                     /locus_tag="KNP36_000900"
     CDS             complement(3424..4623)
                     /locus_tag="KNP36_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="HBF0872789.1"
                     /translation="MKSAYKGYEAYSYLEKGKDISSIEMCKGDKRVKEYLIELDDIQE
                     AKVKSIVDEKIFISLHEHPVLFPEHLERDIFEYNREGKQRCAYEALSRGYYDAIFDNL
                     MDGVCTITSNSGWKWDDILIDLGMRLCDLAHQDFVIKCEKVEDIYRAKSEGKVALIPT
                     LEGAAPIENELDRIDILYGFGIRLMGITYSESNALGSGLKEEKDGGLTNFGKKAVERM
                     NKIGMAIDCSHVGVQTTLDVIEYSKDPIILSHVGARSLWNTKRLTPDEVLIACAKKGG
                     VIGVEAAPHTTITEKNKEHSIESFMEHFEYIKNLVGIDHVAFGPDTVYGDHVKLHSVL
                     AAKFDIKKITGTKEHPKVEYVKGLENPTETSKNIVRYLVKHGYSDEEIEKVLGGNILR
                     VLKQVWK"
     gene            complement(4884..6929)
                     /locus_tag="KNP36_000901"
     CDS             complement(4884..6929)
                     /locus_tag="KNP36_000901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872790.1"
                     /translation="MKKHNILFVSTDDKINIDISKQLENIFGEFCNIDNLVYVNRINI
                     ELSSYELVVCSDNDIKEYIHNNIDKNIPIVIVHRTINIENINQIISIENDSDVMVIDA
                     YKESADETAKIIRKLGLIHINLIPYYPGCDKSKCEIGIITGSRNSIPQNIKQIIDIGD
                     KVIDINTVIEIFTKLNISIDKLHIIKEKYNEDTVSGYRYYTTMNKTMKSFLEIIDEGI
                     ASVDKLGKFIYCNKVFSNLVGIDQNEIISNNFMDLFSDKVVKKIFFQEDEVNDEVVNL
                     NNKKLIINKVNVYENNERIKSIISIKNISAIQVLEDKIQNKLQSKGFVSKYTFESVVG
                     ESKIIKEKINIARKIATTDFSVLILGENGTGKEIFAQAIHNESLRKNKPFVAVNLSSL
                     SDTLIESELFGYDEGSFTGAIKGGKMGIFERAHTGTIFLDEIGDISLDVQQRLLRVLQ
                     EKEVMRMGGSKIIPIDVRIIAATNKDLKKKIKEGSFREDLYYRINVLHIEIPRLRERK
                     EDIPLISKYFLDEINSNKCFTEESMQALTLYEWPGNVRELKNLIYYIDTIVEEDRVDY
                     EHLPEQFRFEKNNTLVNENFDSIILDFKQSNFFEESICILTSIETWNNKNILLGRNKL
                     QEILKEKDIVLSVDQIRKRIDKLKSHGLLLSGVKKQGSFITDEGKNFISYVKIKGVI"
     gene            complement(7340..8149)
                     /locus_tag="KNP36_000902"
     CDS             complement(7340..8149)
                     /locus_tag="KNP36_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0872791.1"
                     /translation="MYYVYVNDINIAVYDLNPSAKKTVLFIHGWPLGHKIFEYQTNIL
                     PKLGYRTVSIDLRGFGKSDATSGGYTYSQLADDIYKVVHAIGLKDFTLVGFSMGGAIV
                     LRYMSLFNGYGVSKLVLAAAAAPSFVQRPPEFPYGMTREDVNKLIAQACTDRPEMVTD
                     FGEKVFASNPPESFRRWFNDIGFSASGIGTIGTAVSLRDEELFNDLKCVRVPTGIFHG
                     KLDEICPYEFAVFMNEKIEDSILYTFEYSGHAIFYDELKLFNQEFLQFLEE"
     gene            complement(8233..8766)
                     /locus_tag="KNP36_000903"
     CDS             complement(8233..8766)
                     /locus_tag="KNP36_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBF0872792.1"
                     /translation="MSGAHYDMHKRNGYSSDEPYPEIKVLGPNKYYAELLMDDYAGVS
                     SEFTSVNQYLYHNFDLDETHRELSEMWINISITEMLHMEILAKTIRLLGGNPVYRGST
                     SSCGAYWNGGFVCYGNSICNRLKLDLHLEHVAINNYYKDISLIEDPYIKAILNRIILD
                     EKLHVSLFEKAIEKYCK"
     gene            complement(8916..10265)
                     /locus_tag="KNP36_000904"
     CDS             complement(8916..10265)
                     /locus_tag="KNP36_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TldD/PmbA family protein"
                     /protein_id="HBF0872793.1"
                     /translation="MELKNFKDILFKKALSEGFEECEIYYYTGENLSINIYEGEVEKY
                     NLDKSFGLSFRGKVNGKIGYSYTEILDDKAVDMLIKNVKDGVNTIENEDVQFIYEGDK
                     HYNDVKTYSKELENLEADKLIDLALEMERETKAYSDKVVNLSKCTISYSVSSNGISNT
                     KGLNLSNKTNMLIGFVVPIIEDNGQKYDGIGYNIANSIEEIKPCEIAKLGVDNALSKV
                     GGKSITSGKYKTILLNEAMVSLLSTFSGIFNADSAQKGLSLLKNREGDMIASPIVTIV
                     DDPLLENGMASTPFDDEGVATFKKEVVLNGKLITLLHNLKTANKAGVKTTGNGIKSSY
                     SSPISIYPTNFYIEKGDKSLDEIIKDIDEGLMVTSFAGLHSGANSVTGDFSLAAKGFY
                     IKEGKKVFPVEQITVAGNYFDLLKDIEAIGEDLEFPMSSIGSPSVVIKELSVAGKDE"
     gene            complement(10277..11659)
                     /locus_tag="KNP36_000905"
     CDS             complement(10277..11659)
                     /locus_tag="KNP36_000905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011967718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TldD/PmbA family protein"
                     /protein_id="HBF0872794.1"
                     /translation="MLSKNIASKVLEKCLITGGDFAEIFEEDTINNSISLIDNKVENA
                     IGGRNYGIGIRIFKGLKSIYAYTSDNSLNSLLDVAYKAAVALGKLEDGKSVILNDSIK
                     INNIHNIKIYPNSIGNKDKVSVMKVAYKSAKEFSNDISQVSVSYLDKDQKILIANTEG
                     IYVEDRRIRTRLGISSIASKGNENQTGFEGPGGCKGFEIFEEIDPEYYAKESARVAHT
                     MLHAKNCPAGNMMVAIDNGFGGVIFHEACGHSLEATSVAKGNSVFADKLGQQIASTKI
                     TAIDDGTIPNYWGSMNIDDEGNPTQKNILIESGILKSYMIDKLNGRRMGMNPTGSSRR
                     QNYKFAPTSRMTNTYIAAGEDRPEDIIKSIPDGLYAKKMGGGSVNPVTGEFNFAVSEG
                     YLIKNGEIQEPVRGASLIGKGSDILMNIDMVGNNVKQAQGMCGSSSGSIPTNVGQPMI
                     RVKEITVGGR"
     gene            11903..13117
                     /locus_tag="KNP36_000906"
     CDS             11903..13117
                     /locus_tag="KNP36_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HBF0872795.1"
                     /translation="MNQEYVKGNPIFTNINKVPRQFPYLTDDIDTDVIIVGGGVTGCI
                     CAYYLAKNNIKSVILEKGRIAHGSTSVTTSLLQYELDDNLIDLTEVMTLKDALKAYNL
                     CTSALEELDTFIELYGNKCDYAKRDTLLYTANKLEVKAIKEEYNLRKENGFDVEYIDE
                     STNPFSFDLKSGLIAKNGGRELDPYKYSHHLIDVSLKNGLQVYENTEVKKVDLSNDKV
                     TAEVSYGYKVHGKKLIVATGYNTSLFTKRNFATKSNTFNIATKPLKNIASWKNNILIR
                     DNCDPYNYLRTTKDNRLIIGGEDVSFDDIENETLANEKYDILEQRLKSMFKDIKDIEV
                     EYKYCGCFASTLDNLGFIGPDNKNNNLWYCLGYGANGILFAILGGIMLSELYLGKQNK
                     NMKLFKVDRFDK"
     gene            13294..15207
                     /locus_tag="KNP36_000907"
     CDS             13294..15207
                     /locus_tag="KNP36_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872796.1"
                     /translation="MKYGGIIMKEILVIAPTKGTYEKSIHIVKKNKYTNIDVVFGNLK
                     EGIPLAEKSINHGTRIIISRGGTYNMLKATYNIPIVEIKVDAYDIIKSYKEVKNSNEP
                     FGIIGFNNVIYGFDIIEEILNKKITMIEIEKEEEIYDAIEKYRKKGINTYIGDTTVAH
                     IVKRLNCKGILIESREENILRAIQQAEQILEATKDEQKRRLQIEAMTDFVHDGIITVD
                     KNFKITLFNKSAEKIFGIKKENALYHNVVDVIPNTVLPQVVETMEPQIGEIQNIGSTK
                     IITNRVPIIVDGQIQGAVSTFQDSKEISSFEHTIRRSLLSKGLSAKYTFDDIIHASEK
                     TKDCIELAKKYACYDTPMIITGESGVGKELFCQSIHNYSKRKNAPFVAVNCAAIPPSL
                     IESEFFGYEEGSFTGARKKGKAGVFELAHEGTIFLDEISEIPLELQGRLLRVLQEKQV
                     MRIGGDKVIPIDVKIICASNKDLKNMMRNGLFRQDLYFRINILTLYLPSLKERKEDII
                     KLSEFFIHKYSSKYNKTPLIITPNIKKALLEREYEGNIRELEGMMERAVIVESFDSIL
                     LEKLSNEYTNNIVDKDNSDFECSNLDLKTLEKKYIYKIYNENNRNTTKTCEILKITRS
                     TLWRKLKEIEDDV"
     gene            15478..16452
                     /locus_tag="KNP36_000908"
     CDS             15478..16452
                     /locus_tag="KNP36_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-keto-3-deoxygluconate permease"
                     /protein_id="HBF0872797.1"
                     /translation="MHILKSVKKIPGGLMVCPLLLGALFNTVCPQALEIGGFTTSLFK
                     TGAMSILALFCLCNGAQINIRQAGKPLTKGIVLTATKFIIGAVLGIIVSKFIGPKGII
                     GITPLAIVATMTNSNGGLFAALAGEYGDSTDVGAISILSLNDGPFFTMLAFGVTGLAN
                     VPIVALFAALIPILLGFILGNLDEDIREFLAPGTTLLIPFFAFPLGAALNFNQIITAG
                     LPGVVLGLGVTIITGMGGYFVMKLIRAEHPAVGAATGTTAGNAAGTPEALAAIDPTLA
                     TIAAVSTVQVAAAIIVTAICCPMLVSYLDKREKKKKSIFKTNKNIEVN"
     gene            16473..16748
                     /locus_tag="KNP36_000909"
     CDS             16473..16748
                     /locus_tag="KNP36_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBF0872798.1"
                     /translation="MNAIIHANEKDNLVTCVRPLIKGEKVSIDGKSYIVNDNIPVFHK
                     MATEDVKKGDVVYKYGEIIGIATVDIKTGDYVHVHNIESTRGRGDKK"
     gene            16761..17924
                     /locus_tag="KNP36_000910"
     CDS             16761..17924
                     /locus_tag="KNP36_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBF0872799.1"
                     /translation="MKLMGYLRENGQFGIRNHVLIIPTSVCSSETATRIASLVPGAIA
                     IPHQHGCCQIGSDIELTAKTLIGFGKNPNVAAVLVVGLGCDGIQAKELASEIATTGKK
                     VNYVVIQECGGTLKTVSKGAEIVSKMAREVSKEVRVEFGMSEITLALECGGSDPTSGI
                     ASNPSIGVASNLLVDEGGSSILSETTEVIGAEHLLATRFEDEEMKDKFLKFVSDVEKR
                     AIAMGEDLRSGQPTPGNKAGGLSTIEEKSLGCMYKAGNKPFKGALEYADIVPPDKKGL
                     YFMDTPGQDIDSITGMVAGGAQIVIFSTGRGTPTGSPISPVIKITGNSDTYNKMPDNI
                     DINAGRIITDGAKIADIGQEIFNEIIEVCNGKHTKAESLGHREFGIYRISSTF"
     gene            18261..20540
                     /locus_tag="KNP36_000911"
     CDS             18261..20540
                     /locus_tag="KNP36_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0872800.1"
                     /translation="MNFENTKNKKIIATLLLTLLLIVSLTCVTFIMNLNKVTHNETER
                     YLVEVSQSISTTINVKCKSIFRTLYSMGDTYFEINDSEKEVNRYLSKKLKLFEFDWLG
                     IIDSNGNFVSALKDTGNVKGQDFYRKALQGKETITPVKSQSGTYGILYSVPLYNGDKI
                     VGAVAAWNTIDTMRNLLSVESFHGEGFSQIIDQDGNFIVSSANKNAPKNVVNFFDMIK
                     HQGKQVDKNKLEEMKINLKKNKTGSMYYTLNDGISKAMHYLPLQEENLYLLSIVPTKT
                     ASAQFDLLLKKAIFINILIVILFLLLIILIMFINQKNRAQLIKIAYVDSVTKGYSKAR
                     FDIEAKKIIQSSSSESYSLVSINIQKFKLINDSFGSEAGDKTLKYIHDVISNYLEPGE
                     LLCRVSNDQFNVLIKTIPQKEILKYIENITNDINSFNKNEECKYFIALSIGVYKIDDP
                     NLPLVSIQDRANVARKNNKGNIGNHPLYTCVFYSDLERLKMIKEKEMENRMEEALNNN
                     EFIVYLQPKISLKDNTIVGAEALVRWQDPNKGLIPPDEFIPFFEKNGFITKLDHYVFE
                     KVCSMIRKWIDNGETPIPVSVNFSRANLNNIDFLEKYRMLRNKYNIPAKLLEIELTET
                     LVFENLQKLINIIDQIHEEGFQCSLDDFGSGYSSLNMLKEIKVDTLKLDRAFFSSPNA
                     DNIAENHVIESIVNLAKKLNMNSISEGVETILQMDYLKKINCDMIQGYVFSKPLPQEI
                     FEKMTFGKKLEETSMDSSV"
     gene            complement(20635..21975)
                     /locus_tag="KNP36_000912"
     CDS             complement(20635..21975)
                     /locus_tag="KNP36_000912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0872801.1"
                     /translation="MENQEALRHEKIWILLFRYSIPAIIAMMVTSLYNVVDRAFIGSM
                     EGIGSIAIAGLGVTMPVFTLIIAFGMLVSVGASTRLSIKLGERNREEAEKILGNALTL
                     SIIISLIITILGLVFLEDILFILGASKDSIFYAKDYMSVILVGSIFNLVAFSLNNAIR
                     AEGNPKLAARTMIVGCVLNLILDPIFIFVFNLGIKGAAIATVLCQIVVFFWVIHYFIR
                     GKSNLKLKKCNLKLNKDIVKKVFAIGMTPFAMEVAISITHMFTNNSLKVYGGDLAIGA
                     MTALTSILLMFMMPVFGLNQGMQTIISYNYGAKQYERAKKTLILSIIVSVVILSFGFL
                     VVQVFPEVFVGIFNKDSDLMDIAVRGISLNLITLPIMGISIVGPVYFQCISKVKHSMF
                     LTLLRQFILFIPLIIVLPIQFNLDGVWLAQPVADFIAMIIVLLFLKREFKTSRV"
     gene            complement(21987..22769)
                     /locus_tag="KNP36_000913"
     CDS             complement(21987..22769)
                     /locus_tag="KNP36_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004460318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872802.1"
                     /translation="MNCINTKNLNVSYGNTDIIKNLNLNIPKGKITTIIGANGCGKST
                     ILKTIGRIISPNSGKIYINGEDIYKKKSKEIAKDMAVLPQSPQAPSGLTVSELISYGR
                     FPHKSGFGNSSKEDREIVNWSLEVTGIAEFKDRNMEDLSGGQRQRAWIAMALAQETDI
                     LLLDEPTTYLDLAHQLEILKLLDELNKKQGRTIVMVIHELNNAARFADHMIGIKKGKI
                     VCEGDAYDVMTKDNLKELFNIDAEIATDPRTNKPICITYDMV"
     gene            complement(22784..23806)
                     /locus_tag="KNP36_000914"
     CDS             complement(22784..23806)
                     /locus_tag="KNP36_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBF0872803.1"
                     /translation="MKNIIKINSKTLLVISILMVLIFITFLLSLNMGSFSIEPMDVIK
                     TFLGQGQRNHEIAIFKLRLPRIVIALLVGSALSTAGVILQGVTKNDLADSGILGINSG
                     AALFVVVYIYLMNGNVYEGMSNLTVFTMPIVALIGALFGAFLIYSLAWKGGINSSRLL
                     LIGIGVNIAFTSILTIFQLKFTTQEFNRVMAWTSGSIWGTSWKYVIAVLPFIVIFMGI
                     TIYKSKYIDVLNLGDEVSISLGVDVEKQRRRLIIYAVILSGVSTAVAGSISFLGLIAP
                     HIGRKIIGPKHKRLIPVSALIGTLLLLIADTISRNLLAPIEIPVGIVVSIIGVPYFIY
                     LMLVND"
     gene            complement(23812..24825)
                     /locus_tag="KNP36_000915"
     CDS             complement(23812..24825)
                     /locus_tag="KNP36_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBF0872804.1"
                     /translation="MTKLSKKNITYLLILVSIVVLVFGIVLSITIGAKDMNLSTVIDS
                     LIKMEDGINMRIVKDVRLPRAIAAALVGGFLAVSGAIMQGITRNPIAEPSVIGITQGA
                     TFAISISLVLQKKLPQLIHGSFSVMMFAFIGASISGLFIYFISSKSRGRVNNVKLALA
                     GVALGTLLISLASAISMYFNLSQQLSFWISGGLVGVKWEGIKLLFVAGGIGFILAIIM
                     APRITILSLGEEVAIGLGQKTNFVRFICIVLVILMTGASVSVSGNIIFIGLIVPQIAK
                     GIVGSDYKYIIPSSLVLGAVLLVYTDILSRMINPPYETPVGSITALIGVPIFIYLVRK
                     GEK"
     gene            complement(24953..25891)
                     /locus_tag="KNP36_000916"
     CDS             complement(24953..25891)
                     /locus_tag="KNP36_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0872805.1"
                     /translation="MKKIKSLAIFISIITTLVLVTACSDKNTEDKDKSETRVVQSVKG
                     EVKIPSNPKKIVDISGSSEELLLAGYKPVATANVDSYETDKLPSYIREELKGVKIVGH
                     SMMDTMDMEAILEVNPDLIIMSQRQEKIYDQLKEIAPVVMMKDYANDWRSKLTDVSKL
                     FDKEEEAKSWLQKYDEKATKLGKEVIEKNGEKTYLPVLASSGQFMVFSDGGIGTLIND
                     DMKLAKPKNMPKQDGITLPMVSMEGLTDIDADHIVVIATEADKKDLENSAIWAQIRAV
                     KDGNVTILDAAPFFSQSYNPIGKELLLESVKNELTK"
     gene            26161..26625
                     /locus_tag="KNP36_000917"
     CDS             26161..26625
                     /locus_tag="KNP36_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016208838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872806.1"
                     /translation="MVHLVYCDNAGKKGEKVLDKILAGTKTMVIRGAAGRKIPHSRVF
                     EDELLYFMEKGTAKISAKATVKKVENYVKLTEDEISKILNENQPKLNLSEKQKVRWHK
                     KCLCLVEFENVEEITPLDFDHQGNMDDWLIVEKIEDVVVGTSIPYNYEKSKF"
     gene            complement(26737..27054)
                     /locus_tag="KNP36_000918"
     CDS             complement(26737..27054)
                     /locus_tag="KNP36_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBF0872807.1"
                     /translation="MDEKMIEISFGIIGFAGDAKGLAFEAIKEAKSGNIDKARECIEK
                     SKESIHKAHKFQTELIQNEANGNKTEISVILIHAQDHLMTAMNFQQLAEEFIDVYERL
                     ESK"
     gene            complement(27067..27798)
                     /gene="chbG"
                     /locus_tag="KNP36_000919"
     CDS             complement(27067..27798)
                     /gene="chbG"
                     /locus_tag="KNP36_000919"
                     /EC_number="3.5.1.105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chitin disaccharide deacetylase"
                     /protein_id="HBF0872808.1"
                     /translation="MTKIIINADDFGYCEAVNYGIISAHNNGIVRSTSMMANMPGVEH
                     GVGLLKENKTLNCGVHMTLSCGRPLLSNLKTIVDKDGFFIRRITDEIIEKMDCDEIYR
                     ELCAQIDRVKGLGIDISHLDSHHHIHTLLSLKPVIEKIVTKYNLPIRGGFEYNLEYSK
                     VVPLIDSFYKENVSEEYFIKNIDEIMKYDVVDIMSHPAFLDDYILNSTSYAIDRTKEH
                     KILTSKKVKEFLEKNGLVISSYRDI"
     gene            complement(27824..29134)
                     /locus_tag="KNP36_000920"
     CDS             complement(27824..29134)
                     /locus_tag="KNP36_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861728.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBF0872809.1"
                     /translation="MKKGLKIVTIGGGSSYTPELVEGFINRYEELPVKELWLVDIEAG
                     KEKLEIVGNLAKRMVKKAGVDMKINLTLDRREALRDADFVTTQLRVGLLDARIKDETI
                     PLSHGVMGQETNGAGGLFKALRTIPVIFDIIKDVEELCPNAWMVNFTNPTGIITEAVF
                     KYTNFRRYIGLCNVPIHLKNDVAKLFNVESDRISMDFAGLNHMVYGLNVSLDGEDVTK
                     EAIDKFVKADISMQNIKAIDFNAEFVKSLGAIPCPYHRYYYKTKEMLEDELREFKEGK
                     ARGQVVKELEEQLFELYKDEKLDVKPPQLEKRGGAYYSDAACNLISSIYNDKKDIQVV
                     NTLNKGSIRDFKDEQAVEVSSVITKNGPKPISIGYLPDSVHGLVSQIKSFEVLAAKAA
                     VYGDYESALLALCINPLIPSDDLAKTILDEMLEAHKDYLPRFNR"
     gene            complement(29231..30544)
                     /locus_tag="KNP36_000921"
     CDS             complement(29231..30544)
                     /locus_tag="KNP36_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872810.1"
                     /translation="MEKFMSFMDKYIVPVAAKIGAQRHLVAVRDAFIVMIPITMVGAL
                     GTLINNLPLEAYKNLMASIFGENWTTFGGDLWWGAIGTMAVFLVIGVAYFLAKSYESD
                     GLQSGLIALSIFFIMAPQIGKIVPEGGTTVVEGWGMIQQTYLGTAALFSSILIGLLST
                     EIFVRLSKVKKLTIKMPDGVPPAVSRSFAKLIPGMLTIMIFTVIGIFIKMLSNGSFLT
                     DILNTYLGAPLSNVADSLGSTMLIAFIIHILWTVGLHGANIALPFTETILMKLGGENA
                     ALAQAGATEGYHVLAGAFFDAFVYLGGSGMVLGLIVALLIAGRRRKEMIVLGGPPAIF
                     NIGEPLIFGLPIVLNPIFMIPFVLAPVICSAVSYLAIDFGLVAPVILPKIPWVTPPIL
                     GGAMATGDWTGGALALFNLILSILIYIPFVIASEKMEANKLKINN"
     gene            complement(30566..30877)
                     /locus_tag="KNP36_000922"
     CDS             complement(30566..30877)
                     /locus_tag="KNP36_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872811.1"
                     /translation="MIKIMLACSAGMSTSLLVTKMEDAAKENGIEAKIWAISEVNLKN
                     EIENCDVLLLGPQVRYVLGKATEMAKPYNIPVEVINMMDYGRCNGKAVLDRAVELNSS
                     K"
     gene            complement(31077..31781)
                     /locus_tag="KNP36_000923"
     CDS             complement(31077..31781)
                     /locus_tag="KNP36_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0872812.1"
                     /translation="MKEPIYKVIENHVRELINSDSLKEGDLIPSEKQLSEEFNVTRMT
                     VRSALNNLVKEGYITRQRGVGSIVIANNIYDNISSVSGFTKEMESKGYKVSNILVSLE
                     IVQADENLSSKLNISLEENVWEIKRVRLANDVRVSYMITYMPVKLFPNLNKTHCENSL
                     YNFVEEVCGYKIAMSEREVQAVISNEECMDNLKLEEPEPLLYISQICKLQNSEIFEYS
                     HTYHYGYTLTLNAVVE"
     gene            complement(31872..33233)
                     /locus_tag="KNP36_000924"
     CDS             complement(31872..33233)
                     /locus_tag="KNP36_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0872813.1"
                     /translation="MKDRLNLTEGRITEKLLKLSLPIMGTSFIQMGYNMIDMIWVGKA
                     GSKAVAAVGTAGFFPWLAMAFIMISKVGGEIKVAQSIGANNISTTKSYMKSAIEINII
                     LAIIYTISLIVLNKQLIGFFRLGDLEVITMSRQYLIIVALGMVFYFINPVFTAIFNGL
                     GNSKTPFRINTVGLITNIILDPILIFGWGFAPKLGVAGAAIATVFAQIVVTTCFIYII
                     VKSKEEYFKLRLFKEIETKYYKVLYKLGLPIAIQSGMFTVFSMLLGVIVASWGPVAVA
                     VQKVGSQIEAISWMTAEGLSVALGSFVGQNYGAKKYSRINKGCKIAITVSSVLGIITT
                     LVLVFAGESIFSIFIDESEAIEKGAVYLKILGYSQFFMCLEIITTGAFKGLGRTYIPS
                     IIITILTGARVPLAYFISRPEMLGLNGVWWSITLSSILKGILMISLFISLLKLGKLYK
                     ISE"
     gene            33732..34886
                     /locus_tag="KNP36_000925"
     CDS             33732..34886
                     /locus_tag="KNP36_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0872814.1"
                     /translation="MKINKKFNRVDMQVSILTAIIVIISSSCVYFFNYTLTYKSMIYS
                     LSERSKHIYEYVERNIDKNTFTEINSKEDQSKKSYKSSKILLESVKNTTGVMYLYTAK
                     KTKDGSLVYVVDGLNSSRSDFRNAGDLIEKEIWGDLNKALDNHILLPKKIKSTSWGYI
                     FISYFPIHNDVGKVVGVIGIEFEAKHQYNTFKFISIVTPIIALLTCLISALIAVILFK
                     RISNPTYTDFANTDYLTGLKNRNAFEIDMNNLNNSNLKNLISIISIDLDGLKKINDKF
                     GHQTGDLYIKQASKIIQYVINKKYIVYRIGGDEYIIILKNLSHKEINNIINNINLKIV
                     EENSTNELKLSMSIGYAIFDEKVDVSLFDTYRRADSQMYDNKRKINKQYQ"
     gene            complement(34968..36686)
                     /locus_tag="KNP36_000926"
     CDS             complement(34968..36686)
                     /locus_tag="KNP36_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBF0872815.1"
                     /translation="MNNNAISSKSISLKSKMNLDIKKCMLTVLVMSLVIFLLAPIIYL
                     FVQAFLDKDGVFVGLQNFQEYLASESLLNSLKNTVFVSVISTVISLTLALVYAYALTR
                     TKIKFKGFFKSLAMFPMFAPTMMHAIGLVYLFGNQGLVTNLLGVHVPIYGAVGIILAQ
                     IIYVFPQSFQILYISLSSTDYRLYEASNTMGISKIREFISITIPSIKYSLISSAFVSF
                     TLCFTDFGAPKVIGGEFNVLSIDVYKQIIGQQNMPMGATVSILLLIPAIISFIVTKKI
                     EKNQNSYITSKSIPYKVKTNKLRDSILGGVVGIIAFGIIAVMLTVILSSLISVWPYDL
                     RLTLEHFSMKNSIDGIKPFINSIKMSLLTAILGTSFVFLFAYLNEKTEKAPYLKSFGY
                     FLSTLPMALPGLVLGIAYVLFFNKLEFNFMDTIYIKNLFNGLYGTLLIMVICNIVHFF
                     SVAFITATTAIKKVDKELDMVAKSMGINSASILKNVTIPLCLPAVLENFMYFFLNSMV
                     TISALVFIYTASSKVAAISIVQLDDKGSTAQAASLAVLILVTNILVKVIYEFIKNRLE
                     KRTNFN"
     gene            complement(36691..37680)
                     /locus_tag="KNP36_000927"
     CDS             complement(36691..37680)
                     /locus_tag="KNP36_000927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0872816.1"
                     /translation="MSYLKINNVFKSYDQKRVLNNISLDIEEGEFLCLLGPSGCGKTT
                     LLRIIAGLEDVNSGTIILQDKDITNLEPSKRGFGIVFQSYALFPNMTAYNNIAFPLKE
                     RKVSKGKIDNKVKEVLETVGLTNEAHKYPKALSGGQQQRIAIARALALEPKFLLLDEP
                     MSALDAKVRHKLRMDIKRLQKELNITTIMVTHDQEEAITMADKIAILNGGDIMQIGTP
                     EEIYQNPQNLFTAQFIGDTNCFDNGDSILTVRPEYVQIEKSTKENYQGIISNIEFRGN
                     LLRVEIKDKLNENFIISDASIKEWVNLNLVEGDLVKISIDEKYYLKYPKVKGA"
     gene            complement(37776..38825)
                     /locus_tag="KNP36_000928"
     CDS             complement(37776..38825)
                     /locus_tag="KNP36_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0872817.1"
                     /translation="MKEFIFTCLCIVVITFMTSCISTTPQTTQGKGNNKLTIYAALEE
                     EQIAYYMEGFREEYPNIDVEIVMDSHGVIASKLLAEKDNPQADIIWGLSAMNMIELKK
                     DGALEAYKPKNYDKVDKKFKDTEDDVSWVGMSVPETAIVVNYKELKKLGIDIPKSYED
                     LIKPEYKGLITMPNPASSGTGYLTVSGLIQMMGEKDAYNYMDKLHKNIATYTHSGSKP
                     AKLAGSGEYPIGITLGYRATQQLSSGEPIEVVFPKEGSGWDLEANALVKKDNIKKEAK
                     LFLDWAISDSAMDRYAHEVAVTSIKTDNPVPKGYSKQPFEQLIKEVDLNSAAKNRSTV
                     LKTWESKYGSKSESK"
     gene            complement(39102..39770)
                     /locus_tag="KNP36_000929"
     CDS             complement(39102..39770)
                     /locus_tag="KNP36_000929"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit D"
                     /protein_id="HBF0872818.1"
                     /translation="MARLNINPTRMEMTRLKKLLKTATRGHKLLKDKLDELMKQFLEI
                     VRENKRLREEAENALDTAYKNFIIARAVMSQEYLGSALMMPKQSVSVDVSTRNIMSVD
                     VPVFDFKTENNQSDIYPYGLAFTSGELDSAMEAFSDAMQPLLRLAESEKSAQLLAQEI
                     EKTRRRVNALENVMIPNYIETIKYIAMKLEENERASTTRLMKVKDMVLKKALEEKKKN
                     DLVV"
     gene            complement(39776..41149)
                     /locus_tag="KNP36_000930"
     CDS             complement(39776..41149)
                     /locus_tag="KNP36_000930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit B"
                     /protein_id="HBF0872819.1"
                     /translation="MIKEYKSIQEVAGPLMLINGVEGVKFDELGEIELSNGEIRRCKV
                     LEVNGDTALVQLFESSTGINLAESKVRFLGKSLDFGVSPDILGRVFSGMGRPIDGGPE
                     IIPDKRLDINGAPINPAARDYPAEFIQTGVSAIDGLNTLVRGQKLPIFSGSGLPHANL
                     AVQIARQAKVRGTDSKFAVVFAAVGITFEDAEFFISDFKATGAIDRSVVFVNLANDPA
                     VERVSTPRMALTAAEYLAFEQDMHVLVIITDITNYAEALREVSAAKKEVPGRRGYPGY
                     LYTDLATMYERAGKMKGHEGSITMIPILTMPEDDKTHPIPDLTGYITEGQIILSRELY
                     KKDIQPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFAAYSRGKDAKELMAILGES
                     ALSEIDLMYAKFADEFEKEYVSQGFRTDRTIEQTLEIGWKLLSMLPKSELKRIRDEYF
                     EKYMPKE"
     gene            complement(41146..42924)
                     /locus_tag="KNP36_000931"
     CDS             complement(41146..42924)
                     /locus_tag="KNP36_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit A"
                     /protein_id="HBF0872820.1"
                     /translation="MKTGTIVKVSGPLVVAEGMRDANMFDVVRVSDKHLIGEIIEMHG
                     DKASIQVYEETSGLGPGEEVVSLGMPMSVELGPGLISTIYDGIQRPLEKMYDISGTNI
                     TKGVEVSSLDRTTKWEFKPKKSVGDKVVAGDIIGGVQETAVVECKIMVPYGVKGTIKE
                     IYSGEFTVEDTVCVITDEKGNDIPVTMMQKWPVRKERPYREKKTPDSLLVTGQRVIDT
                     FFPITKGGVAAIPGPFGSGKTVTQHQLAKWADADIVVYIGCGERGNEMTDVLLEFPEL
                     KDPRTGESLMQRTVLIANTSDMPVAAREASIYTGITIAEYFRDMGYSVALMADSTSRW
                     AEALREMSGRLEEMPGEEGYPAYLGSRLAQFYERAGKVNCLGMDEREGTLTAIGAVSP
                     PGGDTSEPVSQATLRIVKVFWGLDASLAYKRHFPAINWLTSYSLYQEKVDVWADKNVN
                     DNFSAQRAQAMKLLQVESELQEIVQLVGVDSLSDGDRLILEVTRSIREDFLHQNSFHE
                     VDTYTSLHKQYRMMGLILKFYKSAQDAIKQNVTINDIIKLSVLEKIGRAKYVEEGDID
                     AAYDSIEDEIDNELADLIKKRGAEEL"
     gene            complement(43041..43364)
                     /locus_tag="KNP36_000932"
     CDS             complement(43041..43364)
                     /locus_tag="KNP36_000932"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit F"
                     /protein_id="HBF0872821.1"
                     /translation="MLMYKVGVVGDKDSIMGFLALGIDIFPAYDSDEIKKSIHKLVED
                     EYAIIYITEQASLLAKESIAKYKDYQLPAIIVIPGIGGSMGLGMNEVRESSKRAIGAD
                     ILFKE"
     gene            complement(43351..44328)
                     /locus_tag="KNP36_000933"
     CDS             complement(43351..44328)
                     /locus_tag="KNP36_000933"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit C"
                     /protein_id="HBF0872822.1"
                     /translation="MAEEKTYPYAVARIRVLEKQLLNRQMFIQMAEAKSPEDSLRIIA
                     EAGYADTSNNNIHNFENILTQELSKTYEILKSLAPEEKFVDVFLYKNDYHNLKVLIKE
                     EISGVDGEKYLIDGGTIPLIKLRESLANRSFSDLPKIMSSAILEAFDVYNKTQNGQMV
                     DIVLDKATFTSMKETAKESQNKFVIDYVMKVCDLTNLKSFIRVKNMKKDFDMFMNVFV
                     SGGSLDKEKFLEAFSSDTPASCFKSTSYSDVCKNGMDSGFTVFEKLCDDYLMEYVRGA
                     KFKPLTLEPLIAYLYAKESEIKTIRIILTSKLNNIDADTIKERLRDAYV"
     gene            complement(44343..44906)
                     /locus_tag="KNP36_000934"
     CDS             complement(44343..44906)
                     /locus_tag="KNP36_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit E"
                     /protein_id="HBF0872823.1"
                     /translation="MGNEQKMIDRIIADAKQEAQEILDKAKSEADLKVNSANEKAEKE
                     MASYTKLAEAEAEKAASKEISGAYMEAKKQILSKKQEILEEVILEAKNKLLNLKDNEY
                     EEIILNMIEKSNCTDDSEIVLSKKDKKTLKDVLSKKGIKVSDETRDITGGFIVKKGDI
                     EYNYSFEAIIAVEHEYIEQIAAEILFN"
     gene            complement(44958..45449)
                     /locus_tag="KNP36_000935"
     CDS             complement(44958..45449)
                     /locus_tag="KNP36_000935"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit K"
                     /protein_id="HBF0872824.1"
                     /translation="MEFLNALGNGQFLAISGAAIAALFAGMGSAKGTSIAGQAAAGVV
                     TEDPSKFGQLLVLQLLPGTQGLYGFIIAFLILSKAGIIGGDAIPTSAQGLQLLMAGLP
                     IGLVGLVSGIAQGKAAAAGVGIVAKRPEELGKAITFAAIVETYALLGLLVSFLAYNGI
                     AIG"
     gene            complement(45452..47377)
                     /locus_tag="KNP36_000936"
     CDS             complement(45452..47377)
                     /locus_tag="KNP36_000936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="V-type ATP synthase subunit I"
                     /protein_id="HBF0872825.1"
                     /translation="MAIVNMNKISIVGLEAQKSQILKLLMNRGFVQIDDSAFLTEEEE
                     LKNYLVKDSEESEVIMLEQKMSHVNQAINIVSSLVKQKKSLLAPKREFNKIDSEKEGQ
                     VYAEALELNNLHKEIGTIRSNINLLNNNKSMLEPWVNFDIPLENMETKYTKTILGTVP
                     ISANIDALRVKLEDEIPESVIGIVNSDKLMNYVYLITLKETFDDVLEVLKEFNFSVVS
                     LPNEEGTPLQAIKKYNEMIIRQENVSKDKTEEIKRHADSIHMLENLYDFYTIERDQKK
                     IIERLVKTKTTFCLNGWLPSKRADELIKEITEKFNCCVQTEEGSKEEGFPILLENNKL
                     VTPFESVTNMYSYPSTKDIDPNTILTFFFVVFFGMMLSDAAYGLIIAVVCGFVVYKLK
                     IQKGEGNLIKLIGICGVSTTVWGLIFGGILGDLIPIKALINPLEDVMTLMGMSLLFGI
                     IHIYVGLGIKAYTLIRSGKVIDAIFDIGFWYLCITGVCLLIIPFVAGDIGVFSEVGKY
                     LAIIGAIGLVLTQGRSFKGIPVKLFKGFSSLYGITSYFADILSYTRIMALCLTTGVIA
                     QVINLLGAIAGPILAVVIGVVGHTINLLINALGAYVHTSRLQYVEFFNKFYEGGGVPF
                     VPFKYKTKYTSINKKEM"
     gene            complement(47379..47690)
                     /locus_tag="KNP36_000937"
     CDS             complement(47379..47690)
                     /locus_tag="KNP36_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872826.1"
                     /translation="MAFEIIKSIVEAEQTADSIKVKAVTDAESIRADAVNKCESIFAD
                     VKKQAKLMEETLIEKAVTDSRAEVDKILANAKSECLKIEKTAEERKSKAIEAVIGKVV
                     R"
     gene            complement(48320..48595)
                     /locus_tag="KNP36_000938"
     CDS             complement(48320..48595)
                     /locus_tag="KNP36_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="HBF0872827.1"
                     /translation="MNEKLTKILEEAKNDDEFRKELIKTREQRDVMDSFCKVVTSRGY
                     DMTVGELFSMGEEYTSNLLKSVNGGAAYPIEDWSDWYEDFFIMLSNI"
     gene            complement(48710..50119)
                     /locus_tag="KNP36_000939"
     CDS             complement(48710..50119)
                     /locus_tag="KNP36_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L,D-transpeptidase/peptidoglycan binding
                     protein"
                     /protein_id="HBF0872828.1"
                     /translation="MIDGKEVKQESGQKNLKFKIAIVVGVLFVAYIGMAIFFRNHFYF
                     GTTINGVKASGKTVEQVNDLLTSSTNSYTLNLEERNNKKEQIKAKDIDLKFTPDDKVQ
                     KIKDSQSAIGWIGGIFKSKEYNNMITLSYNKDLLEKRFNALSCFDSKNVVEPKSAYPK
                     YDSTKNAYVIVPEVLGNKVKKDDFYKLVQNSINSGNTSISLDESKVYEAPNNTKDSEK
                     LKQAIKTLDKYVGVVVTYDFSDRKETLDGSEINKWLKVDSEKNYDITFDNDAMVEYTR
                     GLSKKYSTFGDSRPFKTATGKDITISGGIYGWLIDKKKEAEALVDVVKAGKNVTREPI
                     YIQKAVSRNKDDIGNTYVEISLSGQHMWFFKNGEMLVSTDVVTGDLARGFATPSGIYP
                     LNYKARNVSLTGQGYSSPVSYWLPFNGNIGIHDATWRNSFGGSIYKSSGSHGCVNTPF
                     SKAKKIYENIEPGTPIILY"
     gene            complement(50490..51152)
                     /locus_tag="KNP36_000940"
     CDS             complement(50490..51152)
                     /locus_tag="KNP36_000940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-binding protein"
                     /protein_id="HBF0872829.1"
                     /translation="MIDISIDDKLKERWPNAKLGCIQAKVAVNKSSEKLINEINEFCD
                     TINQSLKVEDITKLDKIKDARNAYKELGKNPSRYRTSSEALVRRIIQGKGLYTINNIV
                     EINNLISIKSLYPVGTYNVSKLHSPVCFTVGDEGEQYKGIGKELINIENLPILSDSVG
                     KFGSPTSDSERAMITEDANEILICIFSFSQESDIEEYFGYAKELLKEYADGKDIETKI
                     IK"
     gene            complement(51406..53625)
                     /locus_tag="KNP36_000941"
     CDS             complement(51406..53625)
                     /locus_tag="KNP36_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0872830.1"
                     /translation="MTGRNKSFTLITILFLTSLFLTMGYIYIEDTKHLLMSEAKIHIK
                     EVAVQGSQLAQRQIEKDLDVLNIFSNYYASNPDIPNEEKMKNLLDEMENQKFYTMAIV
                     DINGNAENTKGDKFSVKDREFFKNSIKGKKYVSSPYVDEVNKSIKKIAISVPLLNNDK
                     VVGVLYCTYNINTLMKLINISFYENNSISYVVKNNGTIILHPQGDSLSKNIYKLLKQD
                     NDIQEVNRLKKELQENKTGATVLNMLEERRYLGYATMDNGNSENNYIKDWNLIFSIPE
                     TVVFSNSKQIINRAVYAVLSIVLIFIAIIFYIIYIKKSNEKEILSLAYEDKVTYIGNQ
                     NKFYRECSKYLLDKPSLNYIIVYFDINNFKMINDTFGYEFGDNLLITIAKALKEELTE
                     GEVYARLSSDYFAIFCDYKNGRNKIIRKLDNIRSNIESNLSIVFEISLCVGIYFVEEG
                     EVDIQKAVNKANMARSVAKGKNINYAIYNEDVRNKLSEESMILDDIKIALVKNQFEVY
                     YQPKFSLVTGEMIGSEALIRWNHPEHGFISPAVFIPIAEKSKLILKIGRFVFERVCND
                     LYEWKKQGKKIVPVSVNLSRVELYQPDIVKFINKTIKMYNLSSDFIEIEITETVAINE
                     LNILKNVLNELRTYGFSISMDDFGTGYSSISCLRDMPIDILKLDKSFLGGIEHDERSR
                     NIAKSIVSLAKSLDLVVIIEGVESKEQAELMKQFGCDLVQGFYFARPMPAKNFLDLL"
     gene            complement(53901..56555)
                     /gene="adhE"
                     /locus_tag="KNP36_000942"
                     /gene_synonym="adhC"
     CDS             complement(53901..56555)
                     /gene="adhE"
                     /locus_tag="KNP36_000942"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HBF0872831.1"
                     /translation="MAHKEQVIIENKKENEVMSVGLDTVNNVESLVKKLAKIREAQKI
                     FATYSQEQVDKIFLAASLAANKQRVPLAIMAQKETGMGIAEDKVIKNHYASEYIYNAY
                     KETKTCGVIEKDEAFGMTKIAEPIGVIAAVVPTTNPTSTAIFKALLALKTRNGIIFSP
                     HPRAKNSTIEAAKVVLEAAVLAGAPEGIIGWIDEPSLELTTTVMKEVDLTLATGGPGM
                     VKSAYSSGKPAIGVGAGNTPAIIDDSADIKTAVNSILVSKTFDNGMICASEQSVIVLE
                     NIYNEVKKEFKERGAYLLDKDETEKIRNIILVNGGLNSKIVGQTACTIAKLAGFEVPV
                     DTKVLIGEVESVEIEEAFAHEKLSPVLAMYKASDFDDAVRKAEKLVEDGGFGHTSSLY
                     IDDVNQREKLDKFTSAMKTCRILINTPSSQGGIGDLYNFKLAPSLTLGCGSWGGNSVS
                     ENVGVKHLLNIKTVAERRENMLWFRAPEKVYFKKGCLGVALKELKDVMNKKRAFIVTD
                     TFLYNNGYTKAVTDLLDEMNIKYTTFFEVEPDPTLECAKIGAKAMREFNPDVIISIGG
                     GSAMDAGKIMWTLYEHPDVDFQDLAMRFMDIRKRVYTFPKMGEKANFVAIPTSAGTGS
                     EVTPFAVITDQDTGVKYPLADYELMPNMAIVDSDMMMNMPKSLTSASGIDALTHALEA
                     YVSMLATDYTNGLALQAIKSIFEYLPRAYDNGAKDPEAREKMANASTMAGMAFANAFL
                     GVCHSMAHKLGAFHHVPHGVANALLITEVMKFNSSDAPKKMGAFSQYKYPEALKRYAE
                     IASFLGLKGNSDEEKFQSLLVAIEDLKLKVGIPKSIKEFGVEESKFMDSIDEMVIQAF
                     DDQCTGANPRYPLMNEIKDMYLNSYYGR"
BASE COUNT        18944 a         9930 c         6823 g        21253 t
ORIGIN      
        1 ataaatatta aaggggttat ttagttatca ttttttattt ctaaaaatct tttctcaaat
       61 gatttagtta tctatttatc caatttttta cataatttaa tgattaaaaa tattaatttt
      121 ttcactataa agtataaata ttatctgatt attaaaataa atattaatac tataaataaa
      181 aacgaagcat gatttttatt taaataaatc tcaaacttcg tctttactta cttagatatt
      241 tatttacttt ctaaatccta ttatttttaa aaccttatct ttttaatact tcaccacatt
      301 tattctcagt aatctctcca ttttctagcg caatttttcc atttacaatt acatattcaa
      361 caccattggc tagtaattgt ggctttgaaa aatcaatatc ttctgaccta ggataactat
      421 agttatccat gtcaataact gctatatcag ctatcaaccc ttctttaaga atacctctat
      481 tttttatttt aaattgccta gctggtaatg aagtaactct tcttacaatc tcttccaatc
      541 taacaccaga ctttctgtac atattgaaga aaattggaaa agctcctctt ctttgtagtt
      601 caaaccatga catatcccca cccacactaa acaaacaatc tgaaccaacc ataacaaatg
      661 gattatcaat tattttatca tcatgtagtt tatctgggaa atcagctcta tacattcctc
      721 ctaaacaaaa gataagttct tcgtctccat ctaaaagtaa atcgagtaat aacttgtcct
      781 catctattcc tttttgtgta gctatttcac gtattgattt cttttccata ttaatatctt
      841 tagtgtttag aagtattata ctccccctat ctccaagtat aaatgcttct tttaatataa
      901 gtgttcttcc ctcttcattt ctaagagcat ccattacccc atctatacct aattcaaata
      961 gactagatga tattgccata ataaattgaa ttactctttt tttcttcata caatgcccag
     1021 aacttcttgg tactgtgtca accattattt caacaccatt atacctagcc tttaatatct
     1081 catcaaatgc ttctatttca actggactta agtgagatac ttgaacccta gcaccacttt
     1141 tctgcccaac ctctatggct tcttttactg cattatatct tcctatgtaa tctctaatat
     1201 gagatgtata tataccatca tgctctttaa tctgccttgc aatatcaaca agttcatcaa
     1261 tatcagcata cttacttggt atatatgcca atccagtaga tattccaaaa gcaccacttt
     1321 tcattccatc atttattata tctgtaattt catttttttc cttttctgta ggaggtctat
     1381 ccttagaacc tcccataaca ctccatctta tagtcccatg ccccaacaag aatcccatat
     1441 tgacagaaat accactttta gatataaggt cacaatattc tgtaaaatta ttccaacatt
     1501 tatttttatc tataagatac tttttttctt cttcaagtaa tagaccattt ttatacatat
     1561 attcatatac attttcagaa gaatatggtg ttatagaatg tccacaatta ccatttatag
     1621 ttgttgtaac tccttgtttt agaaactttt caaatttacc atctagtatt gctactattt
     1681 cttcatgaac atgagggtca ataaatccag gtgttataat ttttccataa caatcaatct
     1741 ctttatttgt attgctattt atcttagaat ctatttttgc tattaagttg tctttaattg
     1801 ctatatctcc ataaaaacca ggattacctg taccatctat tataaatcca ttttttaaga
     1861 ttaaatcata tatcaaaata ttccctcctt aaaaaccaat ttttaaataa tcttaatgta
     1921 atttttatat ttgaaaatca aattattaaa tttcatattt gaaaattcac tattatttca
     1981 ttgtaattag tcactaagct tatctttata catagctctt gcaattaata tagtaccaaa
     2041 tacacatata agaactacta gagactgtgg tattatacct tgctttgata atataatagt
     2101 caatacagat attacaattg ctactagacc taatttttta tcttgtaaaa atacttgtcc
     2161 aaaaactgac ccaaatagag ctggtaaaat taagtttaat ttttctacta cttcagctgg
     2221 aattttagat agtacgcttc ctcctaaaat tacccctata gttagtatac ttatattcac
     2281 taaaatagat acagctattc ctattgtaga tattatcgag ccttcttctg tacctgattc
     2341 aacttctgct gccttttgag ctgctattga acatggtagc ctcatattag atatattacc
     2401 agaaagaaaa ctcatataag ttcctgggat acctaagatt ggtgaataag aaactggttc
     2461 tattatgtaa tttggagcac tcatactgac aattgccatt gtacttgcta ataatgctga
     2521 tattggaggc ataataccaa atccaaagct caaaattatt ccaggaacta atgctgctat
     2581 aatacccaaa gatagtgtta gtcttccata ccttatcata aaaggtaaat attcttcatt
     2641 gtatatagat tttactttac tcataaaact ccccccttat attactgaag ctattatcat
     2701 tccgctaaac attgatattg taagccccca ctctcttaac cattttatat ttttcttctt
     2761 ttcaagcata cacaatatta ccattatagc cattccactt atacatgcaa ttgttccatt
     2821 atcaaaacgc aacaccctat cagcatttag atatgcaaat gaacccaaca ttgctcctag
     2881 agatattatt ggtataaatg atttcttgcc actagatata acattggtta tcttatctag
     2941 tttatgtcca aatagtaatg tgaatattat ccatcctaaa gaacctaata tcatagtcca
     3001 aactgcattt gtaaatgcaa gttttgtcat ttcaggagaa cctaaagtta tacctaatgc
     3061 atctgttcca aatccggctg acattgattc aaaaattaca gaacctataa atgataatct
     3121 catccatgct ataggcccac ccatagttac tataagcgat accattccag caaatatagt
     3181 cattgaaggc ccaatagctg aaatagcact actcttaaca gctgacttta tttgtttatc
     3241 tgttattccc attgttttac caactttgca agattttata gcaaatataa gggattgtac
     3301 cactactatt gatactgcta ctgtactcgc tatccacaaa agtggatgat tagctaattt
     3361 taaataatcc atttataaaa cctccctata aatcctcaaa ttttattaat atttctaata
     3421 tatctatttc caaacctgtt ttagtactct aagtatattt ccacctagta ccttctctat
     3481 ttcctcatca ctatatccat gctttactaa atatctaaca atgttttttg aagtttctgt
     3541 tgggttctca agacctttta catattctac tttgggatgt tcttttgttc ctgttatttt
     3601 ttttatatca aatttagcag ctagtactga gtgtaatttt acatggtcgc catatactgt
     3661 atctggtcca aaagctacat ggtctattcc tactaaattt ttaatatact caaaatgttc
     3721 cataaatgac tctattgaat gttctttatt cttctctgtt attgtagtat gaggtgctgc
     3781 ttctacacct ataacccctc cttttttagc acatgctatt aatacttcat ctggagttag
     3841 tctctttgtg ttccataaac ttcttgcccc aacatggctt aatattattg ggtccttgct
     3901 atattctatt acatcaagtg tagtttgaac tccaacgtga gagcaatcta ttgccattcc
     3961 aattttattc attctttcaa cagctttttt tccgaaattt gtaagacctc catctttctc
     4021 ttcttttagt cctgaaccta atgcattgga ttcgctgtat gttataccca ttaaccttat
     4081 accaaatcca tacagtatat ctattctatc aagttcattt tctattggtg ctgcaccttc
     4141 taatgttggt atcaatgcta ctttaccttc acttttagct ctgtatatat cttctacttt
     4201 ttcacacttt ataacaaaat cttgatgagc taaatcacat agtctcatgc ctaaatctat
     4261 taatatatca tcccatttcc accctgaatt tgatgttatc gtacatacac catccattaa
     4321 attatcaaat atagcatcat aatatcctct tgataatgct tcataagcac atctttgttt
     4381 accttcccta ttatattcaa atatatctct ttctaggtgt tctggaaata atactggatg
     4441 ttcatgtaat gatataaata ttttttcatc cactatactt ttaaccttag cttcttgaat
     4501 atcatctaat tcaataaggt attctttaac tcttttatct cctttacaca tctcaataga
     4561 tgaaatatct tttccttttt ctaaataact ataggcttca tatcctttgt aagctgactt
     4621 cataacaaca tcctccaagt tctacaattt tttatatttt tcctatgtag caattgatgt
     4681 gccaaaatat aaattttaat tgtataataa atcttgcaaa aaataaaaac agtagtaagg
     4741 ttgatattta ctactgtttt attaaaaata atcttcttag attatttatt caatattttt
     4801 gaattatctt aatcttaaag ataattttat ttatttctat ccattatagg gattttttta
     4861 gggtgttttg cctttttagt cccctatatc actcccttaa tttttacata tgatataaag
     4921 ttctttcctt catcagttat aaaactacct tgttttttta ctccagataa aagtaaacca
     4981 tggctcttta acttatctat tctttttcta atttggtcta cacttaaaac tatatctttt
     5041 tcttttaaaa tctcttgcag tttatttctt cctaataata tatttttatt attccaagtt
     5101 tctatactgg tcaatataca tatactttcc tcaaagaaat tagattgttt gaaatctaag
     5161 ataattgaat cgaaattttc attaactaaa gtattgtttt tttcaaatct aaattgttct
     5221 ggcaaatgct cgtaatctac tctatcttcc tcaactatag tatcaatata ataaattaaa
     5281 tttttaagct ctcttacatt tcctggccat tcatacaatg ttaaagcttg cattgattcc
     5341 tctgtaaaac atttgttgct atttatttca tctaaaaaat acttacttat aagaggtata
     5401 tcttccttac gttctctaag tctaggtatc tctatatgta atacattaat cctataatac
     5461 aaatcttctc taaaagaacc ttctttaatt tttttcttta aatctttatt tgttgcagct
     5521 ataattctaa catctattgg tataatttta cttccgccca ttctcataac ttctttttcc
     5581 tgtaatactc ttagcaatct ctgctgtaca tctaaagata tatcacctat ctcatctaaa
     5641 aaaattgttc ctgtatgtgc tctttcaaat atacccattt ttccaccttt tattgctcct
     5701 gtaaaacttc cttcatcata gccaaaaagt tcactttcaa taagtgtatc tgacaaagaa
     5761 gatagattaa ctgcaacaaa tggcttgttt tttcttagag attcattatg tattgcctgg
     5821 gcaaatattt cttttcctgt tccattttct ccaagtatca acacagaaaa gtctgtagtt
     5881 gctatttttc ttgcaatatt aattttttct tttattattt tactctcacc tacaacactc
     5941 tcaaatgtat actttgatac aaaacctttt gactgaagtt tattttgaat cttgtcctca
     6001 agcacttgaa ttgcacttat atttttaatg cttataatac tctttattcg ttcattattt
     6061 tcataaacat ttactttatt aattatcagt tttttgttat ttaaatttac tacttcatca
     6121 ttaacttcat cttcttgaaa aaatattttt ttgacaacct tatcactaaa taagtccata
     6181 aagttattag atataatttc attttggtct attccaacta gattagaaaa tactttgttg
     6241 caatatataa attttcctaa tttatcaaca gaagcaatac cttcatctat aatctccaaa
     6301 aaactcttca tggttttatt catagttgta taatacctat atccacttac tgtatcttca
     6361 ttgtattttt ccttaataat atgtagttta tctatagata tatttagttt tgtaaagatt
     6421 tctataactg tatttatatc aattacctta tcacctatgt caattatttg ctttatgttt
     6481 tgtggtatgc tgtttctgct tcccgtaata attccaatct cacatttaga cttatcacaa
     6541 cctggataat atggtattag attaatatga attaatccta gttttctaat tatcttggca
     6601 gtttcatctg ctgactcttt ataagcatct ataaccataa catcagaatc attttctata
     6661 cttattatct gatttatatt ttcaatattt atagtacgat gtactattac aataggtata
     6721 tttttatcaa tattattatg tatatattcc tttatatcat tgtctgaaca tactacaagc
     6781 tcatagcttg acagttcaat atttatccta tttacatata ccaagttatc tatattacaa
     6841 aattctccaa atatattttc caattgtttt gatatatcta tatttatttt gtcatcagtt
     6901 gatacaaata aaatattatg ttttttcata gtcccacctc ctgtttaacg agtatagaaa
     6961 gtaataattt ggtctattgt agcacttttt aaaaaagttt taaatcttaa aaatcaaatt
     7021 ttgtaccatt tactattatt ttccataata aaataatgta agctatcttt tttcacatat
     7081 aatttaattt ctaaaacggt tagtttgaca ttattggaat ataaataaaa atttaatata
     7141 aattcgttaa tatattaata catttttaag aatgacaagg aataaattat aacaaatttt
     7201 aggaatatat aataataggg tctcagaact tagttacaag ttctaaaacc ctatttgttt
     7261 agtgtaaaaa acatcataaa atttagctta aatcttttca cataatatta ctctttttct
     7321 aagtgataat aaaatatatc tattcctcta aaaactgtaa aaattcctga ttaaatagtt
     7381 taagctcatc atagaatata gcatgaccac tatactcaaa agtatataaa attgaatctt
     7441 ctattttttc attcataaaa actgcaaatt catacggaca tatttcatct aatttcccat
     7501 gaaatatacc agtaggcact cttacacatt ttaaatcatt aaataattct tcatctctta
     7561 aagatacagc agttccaata gtgccaatac ctgatgcact aaaaccaata tcattaaacc
     7621 atcttctaaa gctttctggt ggatttgatg caaatacttt ttcgccaaaa tcggttacca
     7681 tttctggtct atcagtacat gcttgtgcta tcaatttatt tacatcttca cgtgtcatac
     7741 catatggaaa ttctggaggt ctttgtacaa atgatggtgc agcagctgca gctaatacca
     7801 attttgacac tccatatcca ttaaataaac tcatatacct aagtacgatt gctcctccca
     7861 ttgaaaaacc aacaagggta aagtctttta atccaatagc atgtaccacc ttataaatat
     7921 cgtctgctaa ttggctataa gtatatcctc ctgatgttgc atcagattta ccaaaacctc
     7981 ttaaatcaat tgaaactgtt ctatatccga gttttggcaa tatatttgtt tgatattcaa
     8041 atatcttatg tcctaagggc caaccatgta taaaaagtac agttttttta gcactcggat
     8101 tcaaatcata tactgctatg tttatatcat tcacatatac ataatacata tcaacagcaa
     8161 ctcccttcaa gaaaatgtat gatggttatt ttatatatat gaataaaatg atgaataact
     8221 aaattttcaa atttatttac aatacttctc tattgccttt tcaaataaac ttacatgaag
     8281 tttttcatct aggattattc tatttaatat agcttttata taagggtctt caataagact
     8341 tatatcttta taataattat taatagccac atgctccaaa tgcaaatcta gttttaatct
     8401 gttacaaata gaatttccat aacatacaaa accaccattc caatatgcac cacaagaact
     8461 tgtagaacct ctatatacag gatttccacc caataatctt atagtctttg ctaatatctc
     8521 catatgtaac atttctgtta tagatatatt tatccacatt tcacttaact ctctatgcgt
     8581 ttcatctaaa tcaaaattat ggtatagata ttgatttaca ctcgtaaatt cacttgatac
     8641 tccagcatag tcatccatca ataattctgc ataatactta tttggaccta aaacttttat
     8701 ctctggatat ggctcatcac ttgaatatcc atttcgcttg tgcatgtcat aatgtgcacc
     8761 actcataata tctcctcctt taaatttaat gtatgatatt aattgtatgc atcacaactt
     8821 tttcatataa cttagataat aaaatctact taaataataa aaagccatat taattaaaat
     8881 taacatgacc ttttatccac aaaattactt tttaattatt catcttttcc agctactgat
     8941 agctctttaa taacaactga aggtgaacct atactactca ttggaaattc taaatcttct
     9001 cctatagctt caatatcttt caacaggtca aaatagtttc ctgctactgt aatttgctcc
     9061 actggaaata ctttttttcc ttctttgata taaaagccct tggcagctaa agaaaagtct
     9121 cctgttactg aatttgcacc tgaatgaagt cctgcaaagc tagtaaccat caatccttca
     9181 tctatatcct ttataatttc atctaaagat ttatctcctt tctctatata aaaattagtt
     9241 ggatatatgc ttataggtga tgaatatgaa gattttattc catttcctgt agtctttaca
     9301 cctgccttat tagccgtttt taagttatga agtaaagtta taagctttcc atttaaaaca
     9361 acttcttttt taaatgtagc tactccttca tcatcaaaag gagtagatgc cataccattt
     9421 tctaaaagtg ggtcatcaac tattgtaact ataggagatg ctatcatgtc tccttctcta
     9481 tttttcaata aagataatcc tttttgagct gaatctgcat taaatatccc agaaaatgtg
     9541 ctaagcaaag ataccatagc ttcattaagc aatatagttt tatatttacc tgatgtaata
     9601 ctcttaccac ctactttaga taaagcatta tcaacaccaa gttttgctat ctcacaaggt
     9661 tttatttctt caatagaatt tgctatatta tatcctattc catcatattt ttgtccattg
     9721 tcttctatga taggaactac aaaccctata agcatattag ttttattgct taaattaaga
     9781 cctttagtat tagatatacc attacttgat acagaataag atatagtaca tttagataaa
     9841 tttaccacct tatctgaata agctttagtc tctctttcca tttctaaagc taaatcaatc
     9901 aacttatctg cctctaaatt ttctagctct ttagaataag tctttacatc attatagtgc
     9961 ttatctcctt catatataaa ttgtacatct tcattttcaa tagtgtttac tccatctttt
    10021 acatttttta tcaacatatc aacagcttta tcatctaaaa tttctgtata agaataacct
    10081 atctttccat ttaccttacc tctaaaagat aaaccaaaag atttatcaag attgtatttc
    10141 tcaacttctc cttcatatat atttatactt aaattttctc ctgtataata atatatttca
    10201 cactcttcaa aaccttcact tagagccttt ttaaataata tatctttaaa atttttaagt
    10261 tccacaatta tccctcctat cttccaccta cagtaatttc ttttaccctt atcataggtt
    10321 ggcctacatt agttggtata cttcctgatg atgagccaca catcccctga gcttgtttta
    10381 cgttattccc aaccatatct atattcataa gtatatcgct accttttcca attaaactag
    10441 cacctctaac tggctcttgt atttctccat tttttattaa gtaaccttct gaaactgcaa
    10501 aattaaactc tcctgttaca ggatttacag aaccaccacc cattttttta gcataaagtc
    10561 catctggtat tgactttata atatcttctg gtctatcttc tccagcagca atataagtgt
    10621 tagtcatcct tgaagttggt gcaaatttgt agttttgtct acgagaactt cctgtaggat
    10681 tcattcccat tcgtctacca ttaagtttat ctatcatata agacttcaaa attccacttt
    10741 caatcagtat attcttttga gttggatttc cctcatcatc tatattcata gaaccccagt
    10801 agtttggtat tgtaccatca tctatagctg taatctttgt ggaagcaatc tgttgaccta
    10861 atttatctgc aaatacagag ttcccctttg caactgatgt agcttccaaa gaatgtccac
    10921 aagcttcatg aaatattact ccaccaaatc cattatctat tgctaccatc atattacctg
    10981 caggacaatt tttagcatgc aacatagtat gcgctactct agctgattct tttgcataat
    11041 attctgggtc tatttcttca aatatttcaa accctttaca acctccagga ccttcaaatc
    11101 cagtttgatt ttcattaccc ttagatgcaa ttgaacttat ccctagtcta gttcttattc
    11161 ttctatcctc aacatatata ccttcagtgt ttgcaattaa tattttttgg tctttatcca
    11221 aataactgac acttacttga gatatatcat tactaaattc ttttgcactc ttatatgcaa
    11281 ccttcataac acttacttta tctttatttc ctattgaatt tggataaatt tttatattat
    11341 gtatgttatt tattttaata ctgtcattta atattacact ttttccatct tccaatttac
    11401 ctaaagcaac agcagctttg tatgctacat ccaacagact atttaatgaa ttgtcacttg
    11461 tataagcata tatacttttc aatcctttaa atattcttat tcctatacca taatttcttc
    11521 cacctattgc attttctact ttattatcta ttaaactaat agaattattt atagtgtctt
    11581 cttcaaaaat ctcagcaaaa tctcctccag taattagaca tttttctaat accttagaag
    11641 ctatattttt tgaaagcata aatttacctc ctactttaaa tttttaatta acttttattc
    11701 aatcttttta cttgttaaca aacattatat actatattac ttaaaataag gtaattatga
    11761 atatattata catatgtttt atactaaaat gttatcacat tttatctata catacccata
    11821 taactagata attaaaatgt ataatattat ttgctataga aaataataca ctcatacata
    11881 ataaatttta ggagtgaagt atatgaatca agaatatgta aaaggaaatc ctatttttac
    11941 taatattaat aaagttccaa gacaatttcc ataccttact gatgatattg atactgatgt
    12001 tataattgtt ggtggtggcg taactggatg tatttgtgct tactatctag ctaaaaacaa
    12061 tataaagtct gtcattcttg aaaaaggaag gattgcacat ggaagcacta gcgtgacaac
    12121 ttctctatta cagtatgaat tagatgacaa tttgatagat ttaacagagg ttatgactct
    12181 aaaagatgct ctaaaagcat acaacctttg tacttcagca cttgaagaat tagatacatt
    12241 tatagagcta tatggaaata agtgtgatta tgccaaaaga gatactctac tttatactgc
    12301 caacaaactt gaagttaagg ctatcaaaga agaatataac ttaagaaaag aaaatggatt
    12361 tgatgttgaa tatattgatg aatccacaaa cccttttagc tttgatttaa aatcaggatt
    12421 gatagcaaag aatggaggac gagaattaga cccatataaa tatagtcacc atttgattga
    12481 tgtaagttta aaaaatggtc ttcaagtata tgaaaataca gaagtaaaaa aagtagattt
    12541 atcaaatgat aaggttactg ctgaagtatc gtatggatac aaagttcatg gtaaaaaatt
    12601 aattgtagct acagggtaca atacaagttt atttacaaaa agaaattttg caactaagtc
    12661 aaatactttt aatatagcaa cgaaaccact taaaaacata gcttcttgga aaaacaacat
    12721 tttaattaga gataactgtg acccatataa ttatctaaga actactaaag acaatcgatt
    12781 aattataggt ggtgaagatg taagttttga tgatatagaa aatgaaactt tagccaatga
    12841 aaagtatgat attttagaac aaagattgaa aagtatgttt aaggatataa aagacattga
    12901 agttgaatat aaatattgtg gttgttttgc ttcaacttta gataatttag gttttattgg
    12961 tccagataat aaaaataaca atctatggta ttgcttaggt tatggagcaa atggtatact
    13021 ctttgcaata ttaggaggta taatgttaag tgaattatat cttggcaaac aaaataaaaa
    13081 tatgaaatta tttaaagtag atagatttga taaatagata ttatatatta aaagactgta
    13141 aaaagatgaa actttataat tctaaaagtt aactttgata cagtctttta taatgttcct
    13201 tttaaaaata ctttatttat aattaaatat aaagtaaaat gttaaaatat aactaataaa
    13261 atttagtcat aagataatat ttaagtttat ttgatgaaat atggaggaat tattatgaag
    13321 gaaatactcg ttattgctcc cactaaagga acctatgaaa aatcaattca catagttaaa
    13381 aaaaacaaat atacaaatat tgatgttgta tttggcaatc taaaagaagg tatacctctt
    13441 gctgaaaaaa gtattaatca tggtactaga attatcataa gccgaggtgg aacttacaat
    13501 atgttaaaag ctacttacaa tatacctata gttgaaatta aagtagatgc ttatgatatt
    13561 ataaaaagct acaaggaggt aaaaaattcc aacgaaccat ttggaataat tggatttaat
    13621 aatgtcatct acggtttcga tattatagaa gaaatattga ataagaaaat aactatgatt
    13681 gaaattgaaa aagaagaaga aatttatgat gctatagaaa agtacagaaa gaaaggtata
    13741 aacacatata taggagatac cactgttgca catattgtta agagacttaa ttgtaaggga
    13801 atattaatcg aatctagaga agaaaacata cttagagcca ttcaacaagc agaacaaata
    13861 ctcgaagcaa ccaaggatga acaaaaaaga agattacaga tagaagctat gacagatttt
    13921 gtacatgatg gaataataac agttgataaa aattttaaaa taacattatt taataagagt
    13981 gctgaaaaaa tatttggtat aaaaaaagaa aatgcacttt atcataatgt tgtagatgtt
    14041 atcccaaaca cagttcttcc acaagtagtt gagactatgg aacctcaaat tggtgaaata
    14101 caaaatatag ggagtacaaa aattattaca aatagagttc caataattgt tgatggtcag
    14161 attcaagggg ctgtttcaac atttcaagat agcaaggaga taagttcttt tgaacataca
    14221 ataagaagga gcttattaag caaaggtcta tctgctaaat acacttttga tgatataatt
    14281 catgctagtg aaaagacaaa agattgtata gaacttgcaa aaaaatatgc ttgttatgat
    14341 actcctatga ttattactgg agaatctgga gttggtaaag aactattttg tcaaagtata
    14401 cataactata gtaagcgtaa aaatgcacct tttgttgctg taaattgtgc tgccatacct
    14461 ccatctctaa tagagagtga gttttttggt tatgaggaag gttcatttac aggtgctaga
    14521 aaaaaaggta aagcaggtgt attcgaacta gcacatgaag gcacaatctt cctagatgaa
    14581 ataagtgaaa tccctcttga acttcaaggt cgattattga gggtattgca ggaaaaacaa
    14641 gttatgagaa ttggtggtga taaagttatt cctatagatg taaaaattat ctgtgcttca
    14701 aataaagact taaaaaatat gatgcgcaat ggtttattta gacaagacct ttattttaga
    14761 ataaatatac taacattata tcttccttca ttaaaagaaa gaaaagaaga tattataaaa
    14821 ttatcagaat tttttataca taaatattca agcaaataca ataaaacgcc tttaattatc
    14881 actccaaata ttaaaaaggc acttcttgaa cgagaatatg aaggtaatat aagggaattg
    14941 gaaggtatga tggaaagggc tgttattgtg gaatcatttg actcgatttt attagaaaag
    15001 cttagcaatg aatatacaaa taatatagtt gataaagata atagtgattt tgaatgcagt
    15061 aatttagatt taaaaacttt agaaaaaaaa tatatctata aaatttataa cgaaaataat
    15121 agaaatacta caaaaacctg tgaaattcta aagataactc gctccactct atggcgtaag
    15181 ttaaaagaaa tagaagatga tgtttaaaaa taatacatat ctatatatat caaaacgttt
    15241 tatgtttaat tttaatacat aagacgttta tttgttttca ataaaaaata caattatatg
    15301 ctaaaaagaa tctttgtaag tgaaattctc gtcaatcata cttttaatta taagtaatct
    15361 acagcatttc aatcgattat taaaaataat catgataact aaagatacaa actctatata
    15421 ttggcatagt aattgctttt ataataccta tataaaaatg aaagggagtg atactagatg
    15481 cacatcttaa aatcagtgaa aaagatacca ggaggactta tggtctgtcc cttgttattg
    15541 ggagcactat ttaatacagt atgtccacaa gctcttgaaa ttggaggatt cacaacatcc
    15601 ttatttaaaa ctggtgcaat gagtatactt gctctatttt gtctatgcaa tggagctcaa
    15661 atcaatatca gacaagctgg taaaccattg actaaaggta tagtacttac agcaacaaaa
    15721 tttataattg gtgcagtatt aggtattatt gttagtaaat ttattggacc taaaggtata
    15781 attggtatta cacctcttgc catagttgct accatgacta attcaaatgg aggtctattt
    15841 gctgctcttg caggtgaata tggagactcc acagatgttg gagcaatatc tatcttatct
    15901 ctaaatgatg gtcctttttt tacaatgctt gcttttggag taactggact tgcaaatgta
    15961 cctatagtag cactatttgc agcacttata ccaatactac ttggatttat acttggtaac
    16021 cttgatgaag atatacgaga atttcttgca cctggtacaa cattattaat tcctttcttc
    16081 gcttttcctt taggagcagc attaaacttt aatcaaatta taactgctgg actacctgga
    16141 gttgtacttg gtttaggagt tactataata acaggtatgg gtgggtactt tgtaatgaaa
    16201 cttatacgtg cagaacatcc agcagtaggt gcagctacag gtacaacagc cggaaatgca
    16261 gctggtactc ctgaagcttt agcagctata gaccctactc tagctacaat agcagctgtt
    16321 tcaacagtac aagttgctgc tgctattatt gttacagcaa tatgttgtcc aatgttagtt
    16381 tcctatctag ataaaagaga aaaaaagaaa aaatctattt ttaaaacaaa taaaaatatt
    16441 gaagtaaatt aatacttaag gaggtaaaat taatgaatgc aattattcat gcaaatgaaa
    16501 aagataatct agttacatgt gtcagacctt taattaaagg tgaaaaagtt tcaattgatg
    16561 gaaagtctta catagtaaat gataatatac ctgtctttca taagatggct acagaagatg
    16621 taaaaaaagg tgatgttgta tacaaatacg gtgaaattat aggaattgca acagttgaca
    16681 taaaaactgg tgactatgtt catgtacata acattgaaag tacacgtggt cgtggagata
    16741 aaaaatagga ggaagttaaa atgaaattaa tgggttattt aagagaaaat ggtcagtttg
    16801 gtattcgtaa tcatgtttta attattccaa catctgtatg ttcaagtgag acagctacaa
    16861 gaatagcatc acttgtgcct ggagcaatag caatccctca tcaacatgga tgttgtcaaa
    16921 ttggttctga tatagagctt acagcaaaga cattaatagg atttggaaaa aatcctaatg
    16981 ttgccgcagt tttagtagtt ggtcttggat gtgatggtat tcaagcaaaa gaattagcat
    17041 ctgaaatagc tacaacagga aaaaaggtaa attacgttgt tatacaagaa tgtggtggaa
    17101 cattaaaaac agtttctaag ggagctgaaa tagtaagtaa aatggctcgt gaagtatcaa
    17161 aagaagtaag agttgaattt ggtatgagtg aaattacatt agcacttgaa tgtggtggtt
    17221 ctgacccaac aagtggaata gcttcaaacc cttcaatagg cgttgcatca aaccttcttg
    17281 tagatgaagg tggaagtagc atactaagtg aaactacaga agtaattggt gcagaacatt
    17341 tgttggctac ccgttttgaa gatgaagaaa tgaaagataa gtttcttaaa tttgtaagtg
    17401 atgtagaaaa aagagcaatt gctatgggag aagatttacg tagtggtcaa cctactccag
    17461 gcaataaagc tggtggactt tcaacaattg aagaaaagtc acttgggtgt atgtataagg
    17521 caggcaataa gccattcaaa ggtgctcttg aatatgctga tattgtacct cctgataaaa
    17581 aaggattata ttttatggat actccaggtc aagatataga ttctatcact ggtatggtag
    17641 caggtggtgc acaaattgta atcttttcaa ctggtagagg tactccaaca ggaagcccta
    17701 tttcaccagt tattaaaatc actgggaata gtgatacata caacaaaatg ccagacaata
    17761 tcgatataaa tgcaggtaga attataacag atggtgctaa aatagcagat ataggtcaag
    17821 aaatatttaa tgaaataata gaagtctgta atggtaaaca taccaaagct gaaagtcttg
    17881 gtcatagaga atttggcatt tacagaattt catctacatt ttagattgta acaaaatatc
    17941 ttttataaat ataatactta tgtagataca taagctaaaa gttctttcta atactataaa
    18001 aattttctat actgaaaagg aactgtatca aaattatttt gaaaacagtt ccttttttaa
    18061 cctcttttac tcaaaatatt ataaaataag atttaaacaa taaacgtatc ttgattaatc
    18121 tctaagaaga cataaataaa gctaaatgta aagtgggata aataaaattt aatatctttg
    18181 tatgaaaaga tatttggtat aatatgtctg agagaattct tatttgtaaa caaataaagg
    18241 atggaggatg aaacaaaaga atgaactttg aaaacacaaa aaataaaaaa ataatagcta
    18301 ctttactatt gacactcctt ttaatcgtgt cattaacatg tgtcactttt attatgaatc
    18361 taaataaagt aacacataat gaaacagaac gatatcttgt agaagtttca caaagtattt
    18421 ccactacaat taatgtgaaa tgtaaaagta tatttaggac actatattct atgggagata
    18481 cttattttga gattaatgat agtgaaaaag aagtcaatag atacttatca aaaaaattaa
    18541 aattatttga atttgattgg ttaggtatta tagattctaa tggaaatttt gtaagtgccc
    18601 ttaaagatac aggtaatgtt aaaggacaag acttttatag aaaagccctt caaggcaaag
    18661 aaacaattac tcctgttaaa tcacaatctg gtacatatgg aattttatat tctgtaccac
    18721 tatacaatgg tgataaaatt gttggagctg ttgctgcttg gaatactatt gatactatga
    18781 gaaatttatt aagtgtagaa agctttcatg gtgaaggatt ttcccaaatt atcgaccaag
    18841 atggaaattt tattgtaagt tcagcaaaca aaaatgctcc aaaaaatgtg gtaaattttt
    18901 ttgacatgat taaacaccaa ggaaaacagg ttgataaaaa taaacttgaa gaaatgaaaa
    18961 taaacttaaa aaagaacaaa actggttcta tgtattatac attaaatgat ggtatttcta
    19021 aggcaatgca ttatcttcca ttacaagaag aaaacttata cctcctttca attgttccaa
    19081 caaaaacagc aagtgcacag tttgatttac ttctaaaaaa agcaatcttc atcaatattt
    19141 taattgttat actattttta ttgcttatta tattgattat gtttataaat caaaagaaca
    19201 gggcacaact tataaaaatc gcctatgtag actctgtaac taaaggttac agtaaagcac
    19261 gttttgatat tgaagctaaa aaaattatac agtcatcttc atcagaaagc tattcattgg
    19321 tatctataaa tattcagaaa ttcaaactta ttaatgattc ttttggtagt gaagcaggag
    19381 ataaaacatt aaagtacata catgatgtca ttagtaatta tctagaacca ggagaattgc
    19441 tttgtcgagt ttctaatgac cagtttaatg tacttattaa aactattcct caaaaagaaa
    19501 ttcttaagta catagaaaat atcaccaatg atattaatag tttcaataaa aatgaagaat
    19561 gtaaatattt tatagctcta tctataggtg tatataaaat tgatgaccca aatctacctt
    19621 tagtttcaat tcaagaccgt gcaaatgttg cacgaaaaaa taataaagga aacattggaa
    19681 atcatccact ttatacatgt gttttttata gtgatttaga gcgtttaaaa atgattaaag
    19741 aaaaagaaat ggaaaataga atggaggaag cattaaataa taacgaattt atagtatatc
    19801 ttcagcctaa aataagcctc aaagataata ctattgtagg tgcagaagca ttagtaagat
    19861 ggcaagaccc aaataaaggt cttataccac cagacgagtt tattcctttc tttgaaaaaa
    19921 atggttttat tacaaaactc gaccactatg tttttgaaaa agtatgcagt atgataagaa
    19981 aatggataga taatggagaa actccaatac ctgtttcagt taatttttca cgtgctaatt
    20041 taaataatat agatttttta gaaaaataca gaatgcttcg taataaatac aacattcctg
    20101 ctaagctctt agaaattgaa ttaactgaaa cacttgtatt tgaaaatctc caaaaattaa
    20161 ttaatataat agaccaaatc catgaagaag gttttcaatg ttcactagat gactttggaa
    20221 gtggatactc ttcactcaat atgttaaaag aaataaaagt tgacacatta aaacttgacc
    20281 gtgctttttt tagctcacct aatgcagata atattgctga aaatcatgta atagaatcta
    20341 tagttaattt ggcaaaaaaa ttaaatatga atagtatatc agaaggtgtt gaaacaatct
    20401 tgcaaatgga ttatcttaaa aaaattaatt gtgatatgat acaaggatat gttttttcaa
    20461 aacctctacc tcaagaaata tttgagaaaa tgacttttgg aaaaaaacta gaagaaacca
    20521 gtatggatag ttccgtttaa ataaaataaa aaacttgtct ctataaaata attttaatca
    20581 ttttataaag acaagtcttt ttattttcca atttaatttt attttctaaa tttcttacac
    20641 tcggcttgtt ttaaattccc tttttaagaa taataataca attatcatag caataaaatc
    20701 tgcaactggc tgtgccaacc aaacaccatc taaattaaat tgaattggaa gtacaatgat
    20761 taatggtata aataaaataa attgtcttaa aagagttaaa aacattgaat gtttaacttt
    20821 acttatacac tgaaaataca caggtcctac aatagaaatc cccattatag gcaatgtaat
    20881 tagatttagg cttatacctc ttactgctat atccatcaaa tctgaatctt tattaaatat
    20941 acctacaaat acttctggga aaacttgtac tactaaaaat ccaaatgaca atatgacaac
    21001 tgacactatg atagataata ttaaagtttt ctttgcacgc tcatattgtt ttgcaccata
    21061 attgtatgat attatagttt gcataccttg attcaatcca aacacaggca tcataaacat
    21121 caataaaata gatgtaagtg ctgtcatagc tccaatagct aaatctccac cataaacctt
    21181 tagagaatta tttgtaaaca tgtgagttat acttatagct acttccatag caaaaggtgt
    21241 cattcctatt gcaaatacct tctttactat atctttattc aattttaagt tacatttttt
    21301 tagttttaaa ttggacttcc ctcttataaa ataatgtatt acccaaaaga atactactat
    21361 ttgacagagt actgttgcta tagctgctcc ttttatacct aaattaaata caaatataaa
    21421 tatagggtcc aatatcaggt ttaatacaca tcctacaatc attgtccttg ctgctaattt
    21481 tggattacct tctgccctaa ttgcattatt aagagaaaat gcaactaaat taaatatact
    21541 tccaaccaat atgacactca tatagtcttt tgcataaaat attgaatctt tacttgcacc
    21601 caaaataaaa agtatatctt ctaagaaaac taatcctaat atagttataa ttaaagagat
    21661 aattatagat agtgtcaaag cattacctaa tatcttctct gcttcttctc tatttctttc
    21721 ccctaacttt atagacaatc ttgtgctagc acctactgat accaacattc caaaagctat
    21781 tattagagta aatactggca tagttacacc aagacctgca atagctatag agccaatacc
    21841 ttccatagaa ccaataaaag ctctatctac tacattataa agtgaagtta ccatcattgc
    21901 tattattgca ggtatcgaat acctaaataa taaaatccat attttttcat gtcttaatgc
    21961 ttcttgattc tccatgttgt caccatttac accatgtcat aagttataca aattggttta
    22021 tttgttcttg ggtctgttgc tatttctgca tcaatattaa ataattcttt tagattatcc
    22081 ttcgtcataa catcatatgc atcaccttca caaactattt tacctttctt aatacctatc
    22141 atgtggtcag caaatcttgc tgcattatta agttcatgta ttaccatgac aatagttctt
    22201 ccttgttttt tatttagttc atctaataat tttagtatct ccaattgatg tgccaaatct
    22261 aaatatgttg taggctcatc cagtaataat atatcagttt cttgtgccaa agccatagct
    22321 atccatgccc tttgtctttg tcctcctgat aaatcttcca tatttctatc cttaaattct
    22381 gcaattccag taacttctaa actccaattt acaatctctc tgtcttcttt actagaatta
    22441 ccaaatccac ttttatgagg aaatcttcca taagaaatta attctgaaac ggtaagacca
    22501 ctaggagctt gagggctttg tggaagtaca gccatatctt ttgctatttc tttagacttc
    22561 tttttgtaga tgtcctctcc atttatatat attttcccac tattagggct aataattcta
    22621 cctatagttt taagtattgt cgattttcca caaccattag cccctatgat ggtagttatt
    22681 tttccttttg gtatatttaa atttaaattt tttataatat ctgtgtttcc atatgataca
    22741 tttagattct tagtatttat acagttcata acaacaccct ttcctaatca tttaccaaca
    22801 ttaaataaat aaagtacggc actcctatta tagaaactac tatacctact ggtatttcta
    22861 taggtgctag aagatttctt gatatagtat ctgctattaa aagtaataat gttcctatca
    22921 atgctgatac tggtattaat cttttatgct ttggtcctat tatttttcta cctatatgtg
    22981 gagctattaa acctaaaaat gaaatactac ctgctactgc tgtcgataca ccagataaaa
    23041 ttactgcata tattataagt cttcttcttt gtttttctac atctacacca agacttatag
    23101 atacttcatc acccaaattt aaaacatcta tatatttaga tttataaata gttataccca
    23161 taaaaatcac tataaatgga agcacagcta ttacatattt ccaactggtt ccccaaatgc
    23221 ttcctgatgt ccatgccata accctattaa attcctgtgt tgtaaatttc aattggaata
    23281 ttgtcaaaat tgaagtaaaa gctatgttta cacctatacc aataagtagt aatcttgatg
    23341 aatttatacc acctttccat gcaagagaat atataagaaa tgctccaaat aaagctccta
    23401 taagtgcaac aataggcatt gtaaatacag tcaagttact cataccttca tatacattac
    23461 cattcataag gtatatataa actactacaa acaatgcagc acctgaattt attcccaaaa
    23521 ttccagaatc agctaaatca ttctttgtaa ctccttgaag tattacacct gctgttgata
    23581 atgcagaacc aaccaaaagt gctattacta ttcttggtaa tcttaattta aatattgcaa
    23641 tttcatgatt acgctgaccc tgccctaaaa aagtctttat aacatccatt ggttctatag
    23701 aaaatgagcc catatttaaa ctcaataaaa aagtgataaa aataagcacc attaaaattg
    23761 atataacaag taatgtttta gaatttattt ttataatatt tttcatagta cctatttctc
    23821 cccctttcta acaaggtata taaatattgg cactcctata agtgctgtta tagaacctac
    23881 tggtgtctca tatggaggat ttatcatcct acttaatata tctgtatata caagcaatac
    23941 agctcctaat actaaagagc tcggtattat atacttataa tctgaaccta ctattccttt
    24001 agctatttga ggaactataa gacctataaa aataatatta ccagacactg acacagatgc
    24061 tccagtcatt aatattacaa gtactataca tataaatcta acaaagttag ttttttgtcc
    24121 taatcctatt gccacttctt ctccaagact taatatagtt attcttggag ccataataat
    24181 agctaaaata aatccaatac caccagctac aaatagcaat tttatacctt cccacttcac
    24241 tcctacaagc cctcctgata tccagaaact taattgttga gataggttaa aatacataga
    24301 tattgctgat gccaaagaaa ttagcaatgt accaagagcg actcctgcaa gagctaattt
    24361 tacattatta actcttcctc ttgatttaga acttataaaa tatataaata atccacttat
    24421 acttgctcca ataaatgcaa acatcattac actaaaactt ccatgtataa gttgaggaag
    24481 ttttttttga agtaccagtg atatcgaaat tgcgaatgta gctccttgtg taattcctat
    24541 aacagatggt tcagctatag gatttctcgt tattccttgc attattgccc cagaaactgc
    24601 taaaaatcct ccaacaagtg cagctgctat tgcccttgga agtctaacat cctttactat
    24661 tctcatattt attccatctt ccatttttat caaactatct ataacagttg atagattcat
    24721 atcttttgcc ccaatagtta tggataatac aattccaaat acaagtacaa ctatacttac
    24781 taatatcaac aaataagtta tatttttttt actcagctta gtcaattatc ctacctcctt
    24841 ttccctttta atcgtcagta taatatcatc tattaagtat tttaatttta agatttatta
    24901 aaaataggtg tgaaaaatga atatcattat ctcacaccta ctaagttaag aattactttg
    24961 ttaattcatt tttaactgat tctaataata actcttttcc aattggattg tatgattgac
    25021 tgaaaaatgg agcagcatca agtattgtta cattaccatc ttttactgct cttatttgag
    25081 cccagatagc actattttct aaatcttttt tatctgcttc tgtagcaatt acaactatat
    25141 ggtctgcatc tatatctgtt aaaccttcca tacttaccat tggtagtgtt attccatcct
    25201 gttttggcat attcttaggt ttagctaatt tcatatcatc attgattaga gtacctattc
    25261 caccatcact aaataccata aattgacctg aacttgccaa cactggtaaa taagtttttt
    25321 ctccattctt ttctataact tccttaccta actttgtagc tttttcatca tacttctgta
    25381 gccaactttt agcttcttct tctttgtcaa ataactttga aacatcagtt aacttgcttc
    25441 tccagtcatt tgcataatct ttcatcataa ctacaggagc tatttctttt aattggtcat
    25501 atattttttc ttgtctttga ctcattatta ttaaatcagg atttacttct aatatagctt
    25561 ccatatccat agtatccatc attgagtgcc caactatctt tacaccttta agctcttctc
    25621 ttatgtaact tggtaattta tcagtttcat atgagtctac atttgctgtt gcaacaggct
    25681 tataacctgc taataatagt tcttcactac ttcctgatat atcaactatt tttttaggat
    25741 ttgatggtat cttaacctct cctttaacag attgtacaac tcttgtctct gatttatctt
    25801 tatcctctgt attcttatct gaacatgctg taacaagtac taacgtagtt ataatagata
    25861 taaatattgc aagtgatttt atttttttca tgattacttc tcctacttgt ttattatact
    25921 tacatgatat tgattatcat aagcacatat ttattatagc atttttctat ttttagtcaa
    25981 tattattttg taaaaggata aaaattccta attaatctta attatatata gcttagataa
    26041 ggttttctta tattaaacag tattttttta aagaattgga cacaaataca atgacttttc
    26101 agttaaacaa tgataaaatg caatttatag ataatgaatt tagtaaggag gattcaaaac
    26161 atggtacatt tagtatattg tgataatgca ggaaaaaaag gagaaaaggt cttagataaa
    26221 atcttggctg gaacaaaaac aatggttatt agaggtgctg ctggtagaaa aataccacat
    26281 agtagagtat ttgaagatga gttactttat tttatggaaa aaggaactgc aaaaatatct
    26341 gcaaaagcca ctgttaaaaa ggtagaaaac tatgttaaat taacagaaga tgaaatttct
    26401 aaaattttaa atgaaaatca accaaaatta aatttatctg aaaagcaaaa agttcgttgg
    26461 cataaaaaat gtttatgctt agttgaattt gaaaatgttg aagaaataac acctcttgat
    26521 tttgaccatc aaggaaatat ggatgattgg cttattgttg aaaaaattga agatgtagtt
    26581 gttggtacta gtatacctta caattatgag aagtctaaat tttaaagtat caataacata
    26641 atactatatt gctaaactct acttaaataa aaaaagagtg catttaataa ttataaaaat
    26701 tatttttata cactcttttt taataataat tttaaattac ttactttcta atctttcata
    26761 tacatctata aattcttctg ctaattgttg aaaattcata gctgtcatta aatggtcttg
    26821 tgcatgaata agtataacac ttatttcagt tttattacca ttagcttcat tttgtatcaa
    26881 ttctgtttgg aatttatgag ctttatgaat tgattctttc gacttttcaa tacattctct
    26941 agctttatct atattcccgc tctttgcttc ttttattgct tcaaatgcta gccctttcgc
    27001 atcacctgca aatccaatta ttccaaaaga tatctctatc atcttctcat ccatttattc
    27061 gacctcctaa atatctctat agcttgatat gactaatcca ttcttttcta aaaattcttt
    27121 gactttttta gatgtaagta tcttgtgctc tttcgttcta tcaatagcat aagatgtaga
    27181 atttaaaata taatcatcta aaaaagctgg gtgagacata atatccacta catcatactt
    27241 cattatttcg tctatatttt ttataaaata ttcttcactt acattttcct tataaaaact
    27301 atctattaaa ggaactactt tagaatactc taaattatat tcaaatccac ctcttattgg
    27361 aagattatac ttggttacaa tcttctctat tactggcttt aaacttaata aagtatggat
    27421 atgatggtga ctatctaaat gagatatatc tattccaagc ccttttaccc tatctatttg
    27481 agcacaaagt tctctataaa tctcatcaca atccattttt tcaataattt cgtctgtaat
    27541 cctcctaata aaaaaaccgt ctttatcaac aatagttttt aagttagata ataatggtct
    27601 accacaactt aaagtcatat gaactccaca atttaaagtt ttattttctt taagtaagcc
    27661 tactccatgt tctaccccag gcatatttgc catcatagaa gtagacctaa ctataccatt
    27721 attatgagct gaaattattc catagttcac agcttcacaa tatccaaaat catctgcatt
    27781 tattataatt ttagtcatac cataacctac tttctataga caactatcta ttaaatctag
    27841 gaagataatc tttatgagct tccaacattt cgtctaatat agtttttgct aagtcatcag
    27901 atggaatcaa tgggtttata caaagtgcca aaagagcaga ttcataatcg ccatatacag
    27961 ctgctttagc tgccaatact tcaaatgatt tgatttgact tactaatcca tgcacagaat
    28021 ctggtaaata tcctatactt attggttttg gaccattttt tgttattaca ctacttactt
    28081 ctaccgcttg ttcatcttta aaatctctta tagaaccctt atttaatgta ttaactactt
    28141 ggatatcttt tttgtcgttg tatatagaac ttattaaatt acaagcagca tcactatagt
    28201 aagcccctcc tcttttttca agttgaggtg gttttacatc taatttttca tccttatata
    28261 attcaaataa ttgttcttcc aattctttaa ctacttgacc tctagctttt ccctctttaa
    28321 actctctcaa ctcatcctca agcatttctt tagttttata gtagtatcta tgatatggac
    28381 aaggtattgc acccaaagat tttacaaatt cagcattaaa atcaattgcc tttatatttt
    28441 gcatacttat atctgctttg acaaatttat caattgcttc ttttgtaaca tcttctccat
    28501 ctaaagatac atttagacca taaaccatat gattaagacc tgcaaaatcc atacttattc
    28561 tgtcactttc tacattaaat agtttggcaa catcattttt taaatgaatt ggcacgttgc
    28621 atagacctat atatcttcta aaattagtat atttgaatac agcctctgtt attattcctg
    28681 ttggatttgt aaaattcacc atccatgcat ttggacataa ttcttccaca tcttttatta
    28741 tatcaaatat aactggtatt gtgcgaaggg ctttaaataa acctccagca ccattagttt
    28801 cctgccccat aactccatga gataaaggaa tagtttcatc ttttattctc gcatctaaaa
    28861 gacctactct aagttgtgtt gtcacaaagt ctgcatctct tagagcttct cttctatcta
    28921 aagtaagatt tattttcata tctactccag ctttttttac catcctctta gctagatttc
    28981 caactatctc taatttttct tttccagctt ctatatctac aagccataat tcctttacag
    29041 gtaactcttc atatctattt ataaaaccct ctacaagctc aggagtataa cttgaacctc
    29101 ctccaattgt aactattttt agtccctttt tcatctcatt ataccatcct tacctataat
    29161 ttaatatact ctacaaaacc ccatacattt atttaaaact ctatacattt atttaccgaa
    29221 ataaaactac ctagttgtta attttcaatt tattagcttc cattttttca gacgctatga
    29281 caaatggaat atatattaat attgataata ttaaattaaa tagtgctaaa gctccaccag
    29341 tccagtcacc tgtagccatt gctccaccta atataggagg tgttacccaa ggtattttag
    29401 gtaaaattac tggtgctact aatccaaaat ctattgctaa gtatgataca gcactacata
    29461 ttactggtgc aagtacaaat ggaatcataa atataggatt taaaactatt ggaagtccaa
    29521 atatcaatgg ttctcctatg ttaaatattg caggtggacc acctaatact atcatctctt
    29581 tacgtcttct tccagctatt aataaagcta ctattaatcc caataccatt ccagaaccac
    29641 ctaaatatac aaatgcatca aagaatgcac ctgcaagtac atggtatcct tccgttgctc
    29701 ctgcttgagc caaggcagca ttttctccac ctaatttcat aagtatagtt tctgtaaaag
    29761 gaagtgctat atttgcacca tgaagtccaa cagtccaaag tatatgaatt ataaatgcaa
    29821 taagcattgt agaacctaga ctatcagcta catttgatag tggtgctcct aaataagtat
    29881 ttaaaatatc tgttaagaaa cttccattag aaagcatttt tataaatatt cctattacag
    29941 taaatatcat tatagttaac attcctggta ttaactttgc aaatgatctt gaaactgctg
    30001 gtggaactcc atctggcatt tttatagtta atttctttac cttagataat cttacaaata
    30061 tctcagttga taataatcct attaatatag aagagaataa agctgctgta cctaagtagg
    30121 tttgttgtat cattccccat ccttcaacta ctgtagttcc tccctcagga actattttac
    30181 caatttgtgg agccattata aaaaagatag ataaagctat aagcccagat tgtaacccat
    30241 cactctcata agattttgct agaaaataag caacacctat tactaagaat actgccattg
    30301 tacctattgc tccccaccaa aggtcgcctc caaatgtggt ccagttttct ccaaatatac
    30361 ttgccatcaa atttttgtat gcttccaatg gtaagttatt tatcaatgtt cccaatgcac
    30421 ctaccatagt tataggtatc attactataa atgcatctct tactgctact aagtgccttt
    30481 gagctcctat tttagcagct acaggcacta tatatttatc cataaatgac atgaattttt
    30541 ccattttaca tcctccagta caactttatt ttgaactatt taactctaca gctctatcta
    30601 acacagcttt tccattacat cttccataat ccatcatatt tataacttct actggaatat
    30661 tatatggttt tgccatttca gttgcttttc ctaatacata tctaacttga ggccctaaaa
    30721 gtaagacatc acaattttct atttcatttt ttaagttcac ttctgatata gcccatattt
    30781 ttgcttctat accgttttcc tttgctgcat cctccatttt tgtaactaat aaactagttg
    30841 acattcctgc tgaacaagct aacattattt ttatcatttt ttcccctcca aattagattc
    30901 attaaatatt ttttaagtca taagtttttt aaactataca tttaaaatat gtttttctat
    30961 taattttttc ttaatgtata tatcttattt ttaaatgtat atacatttaa ttcttgatat
    31021 tattatatac caaatgtata tacatttcaa gaaaactttt tcattttatt taaattttat
    31081 tcgacaacag cattcaaagt taatgtatat ccatagtgat atgtgtgtga gtactcaaaa
    31141 atctcactat tttgtaactt acaaatttgg cttatatata aaagtggctc tggttcttct
    31201 aattttagat tatccataca ctcttcattc gatattacag cttgtacttc tctctctgac
    31261 atggctatct tgtatccaca cacttcttca acaaaattat aaagagaatt ttcacaatga
    31321 gtcttattta aatttggaaa taacttaact ggcatataag taatcatata tgaaactctt
    31381 acatcattag ctaatcttac tctttttatt tcccaaacat tttcttctaa acttatattc
    31441 aacttacttg ataaattttc atctgcctga actatttcaa gagataccaa tatattagat
    31501 actttatagc ctttactttc catctcttta gtaaatccac ttacagacga tatattatca
    31561 tatatattat ttgcaataac tatactacct acacctcttt gtctagttat atagccttct
    31621 ttaactagat tattaagtgc agaccttaca gtcattctag ttacattaaa ttcttcactc
    31681 agctgttttt cagaagggat taaatcccct tctttcaaac tgtctgaatt tattaactct
    31741 ctaacatgat tttctataac tttataaatt ggctctttca tttaattcac tccttattaa
    31801 atcttttata taataagata attttatata caaacaaaga aaatgtctat acatttaaga
    31861 taatttaaat tttattcaga aatcttgtac aactttccga gttttaataa agatataaat
    31921 agacttatca ttaatatacc ttttaatata cttgataagg ttatactcca ccatacacca
    31981 tttagaccca acatttctgg tctagatata aagtaagcca atggtactct tgcaccagtc
    32041 agtatagtaa ttataataga aggtatatag gttctcccta atcctttgaa agctcctgtt
    32101 gttattattt ctaaacacat aaaaaattga gaatagccta atattttaag ataaactgct
    32161 cctttttcta ttgcctcact ttcatctata aaaatagaaa atatactctc tcctgcaaac
    32221 actaatacta aagtagttat tataccaagt acagaagata cagttatagc tattttgcaa
    32281 cctttattta ttctagaata cttcttggca ccataatttt gtccaacaaa actgcctaat
    32341 gcaactgata gcccttcagc cgtcatccag gaaattgctt ctatttgtga gcctactttt
    32401 tgtactgcaa cagccacagg cccccatgat gctactatta ctcctaatag cattgagaat
    32461 actgtaaaca taccactttg tattgctata ggtaatccca atttatacag aactttataa
    32521 tatttagtct ctatttcttt aaatagtctt aatttaaaat attcttcttt acttttaact
    32581 attatatata taaaacatgt agtaactact atctgagcaa atacagttgc aatagcagct
    32641 cctgcaacac caagttttgg agcaaatccc catccaaaaa ttaatatagg gtcaagtata
    32701 atattagtta ttaatcctac tgtattaata cgaaaaggag ttttactatt tccaagacca
    32761 ttgaaaattg cagtaaatac tggattaata aaataaaata ccatacctag agctactatt
    32821 atcaaatact gtctagacat ggttataact tctaagtctc ctaatctaaa aaaacctatc
    32881 aattgtttat taagtactat taaagaaatt gtatatatta ttgctagtat aatatttatt
    32941 tctattgctg acttcatata tgatttagta gtgcttatat tatttgcacc aatactttgt
    33001 gctactttta tctctccacc tacttttgaa atcataataa atgccattgc aagccatgga
    33061 aaaaaaccag ctgttccaac tgcagctact gctttacttc cggctttacc aacccatatc
    33121 atatctatca tgttataccc catctgtata aatgaagtcc ccattattgg aagtgatagc
    33181 ttaagtaatt tttctgtaat tcttccttct gttaaattaa gtctgtcttt cattttccac
    33241 ctcttttata ttaaatttat ttgcttatat agctagatta atcattttat ttgattgagt
    33301 tcactatcct tcaatttata ttatcatatc tcaggattgc atctcaatca tacttatgtt
    33361 taagatacag tattttacct atctatgata aaattaatac ttatgaatat aaatctagcc
    33421 atttcatcaa tacatattct aacctttaac ttaacttcaa ttaagtatac atatcgtaac
    33481 caattagaat attttatacg gtatcttcca ttaataaaca accaatatca atgatttata
    33541 tataatttta tttatacata aaatagtata ctataataat aaaaaaacta tatttgaatg
    33601 ctttaagcat gtttactaat tgtaatttcc acacaaattt gataatatat gaatatatta
    33661 tggtgaaatt tatagatata tattaattat ggggagattg tgggaggttc ttttcacaag
    33721 acatttaagc tatgaaaata aataaaaaat tcaatagagt tgatatgcag gtttcaatac
    33781 ttactgcaat tattgtaata atatcttcct catgtgtata tttttttaat tatacactaa
    33841 cttataagag catgatatac tctttaagtg agaggtcaaa acatatctat gaatatgtag
    33901 aaagaaatat tgataaaaat acctttactg aaattaattc taaagaagac caatcaaaaa
    33961 agtcttataa aagttctaaa atccttttag aatctgtaaa aaatactact ggagtcatgt
    34021 atctatatac tgctaaaaaa acaaaagatg gatcactagt atatgttgtt gatggtttaa
    34081 attcatctag gagtgatttt agaaatgctg gtgatttgat agaaaaagag atttggggag
    34141 accttaacaa agcattagat aatcatatat tgttacctaa aaagattaaa tcaacatctt
    34201 ggggatacat atttatatcg tattttccta ttcacaatga tgttggtaag gttgttggag
    34261 taataggaat tgaatttgaa gcaaaacatc aatacaatac atttaaattt ataagtatag
    34321 ttacaccaat aatagcatta ttaacttgtc taatatcagc attgattgca gtgattctat
    34381 ttaaaagaat atctaatcct acatatactg attttgctaa tacagattat ttaacaggcc
    34441 taaaaaatag aaatgctttt gaaatagata tgaataactt aaacaattca aatctaaaga
    34501 atctaatatc tatcatatca atagatttag acggtttaaa aaagattaat gataaatttg
    34561 gccatcagac aggagactta tatattaagc aagcaagtaa aattatacaa tatgtaataa
    34621 ataaaaaata tatagtttat cgtattggag gtgatgaata cataattatt ctaaaaaatt
    34681 tatctcacaa agaaataaat aatattataa ataatattaa tttaaaaata gttgaagaaa
    34741 actcaactaa tgaattaaaa ttatcaatgt ctattggata tgctattttt gatgaaaaag
    34801 tagatgtttc tttatttgat acatatcgtc gtgcagattc tcaaatgtat gataacaaaa
    34861 ggaaaattaa taaacaatat caataataaa tttaaaaagt ctattcttta aataataaat
    34921 cacaagaata gactttttta aatttgtgtt tttataagat aaattattta attaaagttt
    34981 gttctttttt ctaaacgatt ctttataaat tcatatatta ctttcactaa tatatttgtg
    35041 actaatatta acacagctag tgatgctgcc tgtgcagtac tccccttatc atctagttgt
    35101 acaattgata ttgcagctac ttttgaactt gcagtatata taaaaactaa tgctgatatt
    35161 gtcaccatgg agtttaggaa aaagtacata aagttctcta aaactgctgg caaacaaagt
    35221 ggtatagtta cgttcttaag aattgatgcg ctgtttattc ccattgattt agctaccata
    35281 tccaattctt tatctacttt cttaatagca gtagtagctg ttataaatgc tactgaaaag
    35341 aaatgaacta tattacatat aaccattata agtaatgttc catataatcc attaaacaaa
    35401 ttcttaatgt atattgtatc cataaaatta aactctaatt tattaaaaaa taatacataa
    35461 gctataccta aaactaatcc tggcaatgcc ataggcaatg tacttaaaaa atacccaaat
    35521 gattttaaat atggagcttt ttctgttttt tcattcaaat atgcaaataa gaaaacaaag
    35581 ctcgtcccta gaatagctgt caatagtgac atttttattg aatttataaa tggtttaatc
    35641 ccatcaatac tgtttttcat agaaaaatgt tccagtgtca gtcttaaatc atatggccaa
    35701 actgatatta atgaagataa gattacagtt aacattacag ctattatacc aaatgcaata
    35761 attcctacaa cccctcctaa aatactatct cttaacttat tagttttaac cttatatgga
    35821 attgactttg aagttatata tgaattttga tttttttcaa tttttttagt tactataaac
    35881 gatattattg caggtattaa aagtaatatt gatacagttg ctcccattgg catattctgt
    35941 tgccctataa tttgcttata tacatctatt gataatacat taaactctcc tcctatcacc
    36001 tttggagctc caaaatctgt aaaacataat gtaaacgata cgaatgcaga acttattaaa
    36061 gagtatttta tacttggtat tgttatgctt ataaattctc ttatcttgct tatccccata
    36121 gtattactag cttcatatag tctataatcg gttgaactta gagatatata aagtatttga
    36181 aatgattgag gaaatacata tataatttgt gccaatatta ttcccactgc tccatatatt
    36241 ggaacatgca ctccaagtaa attagttacc aaaccttgat ttccaaataa atatactaga
    36301 cctattgcat gcatcattgt tggagcaaac ataggaaaca tagctaatga tttaaaaaaa
    36361 cctttaaatt taatctttgt tctagttaat gcatatgcat atactaatgc aagtgttagt
    36421 gatattacag ttgatataac tgatacaaat actgtatttt ttagagaatt taatagagat
    36481 tcagaagcca agtattcttg aaagttttgt aatcctacaa agactccatc tttatctaaa
    36541 aaagcctgta caaatagata tattataggt gctaataaaa atattactaa agacataact
    36601 aatactgtaa gcatacattt ttttatatct aaattcattt ttgatttaag acttatactt
    36661 ttagaactta tagcattatt attcatacac ttatgctcct ttaacttttg gatactttaa
    36721 atagtatttt tcgtctatac ttatttttac aaggtcacct tctactaaat ttaaattaac
    36781 ccactctttt atagaagcat cacttattat gaaattttca tttaatttat cttttatttc
    36841 aactctcaat aaattccctc taaactctat atttgatatt attccttggt agttttcttt
    36901 tgtcgatttc tctatttgaa catattctgg tcttacagtt aatatagaat ctccattatc
    36961 aaaacagttt gtatctccta taaattgagc tgtaaatagg ttttgaggat tttggtatat
    37021 ttcttctgga gtccctattt gcattatatc tcctccattt agaatagcta ttttatctgc
    37081 catagttata gcttcttctt ggtcatgtgt taccattatt gtcgttatat taagttcttt
    37141 ttgtaatctt ttaatgtcca ttctaagctt gtgtctaacc tttgcatcta atgcggacat
    37201 tggttcatct aaaagtaaaa actttggttc aagagctaat gctcttgcta ttgcaatcct
    37261 ctgttgttgc ccacctgata atgctttagg atatttatga gcttcattag tcaatccaac
    37321 tgtttcaagt acttccttaa ctttattatc tatttttcct tttgaaactt ttctctcttt
    37381 tagtggaaaa gctatattgt tataagcagt catattcgga aataatgcat atgattgaaa
    37441 tactatacca aaacctctct ttgatggctc taaatttgta atatctttat cctggagaat
    37501 tatagttccg ctatttacat cttcaagacc tgctattatt ctaagtaatg tagttttacc
    37561 acatccacta ggtccgagta aacatagaaa ttctccttct tcaatatcca aactaatatt
    37621 atttaaaacc cttttttggt cataactttt aaacacatta tttattttta agtaactcat
    37681 atcttatctc tccttatata gttatttttt tattttaaat tttatatcct actttttctt
    37741 ctaaaattct ttcatctaaa ttattaattt aaactttact tactttcaga ttttgaaccg
    37801 tattttgatt cccaagtttt aagtactgta cttctgtttt tggcagcaga gtttaaatca
    37861 acttctttta taagctgttc aaatggttgt ttagaataac cttttggaac tggattatct
    37921 gtctttatgg aagtaactgc tacttcatgt gcatatctat ccatagctga atcacttatt
    37981 gcccaatcta aaaatagctt tgcttctttt tttatattat cttttttaac taaggcattt
    38041 gcttctaagt cccagcctga accttccttt ggaaatacaa cctctatagg ttctccacta
    38101 gataattgtt gtgtagctct atatccaagt gtaataccta ttggatactc tccagagcca
    38161 gctaacttcg caggttttga acccgagtgt gtatatgtgg ctatattttt atgtaattta
    38221 tccatgtaat tgtaagcatc tttttcaccc atcatttgaa taagccctga tactgtaaga
    38281 taccccgttc cagatgatgc tggatttggc attgttataa gtcctttata ttctggtttt
    38341 attaaatctt cataactttt tggaatatct atacctagtt tcttaagttc cttataatta
    38401 actactattg ctgtctctgg gacactcatt cctacccaag atacatcatc ttcagtatct
    38461 ttaaattttt tatcaacttt atcataattt ttaggcttat atgcttcaag tgcaccatct
    38521 ttttttagct ctatcatgtt cattgctgat aatccccata taatatctgc ttgtggatta
    38581 tctttttctg ctaatagttt tgaagctatt acaccatgag aatccataac tatctctaca
    38641 tctatattgg gatactcttc tctaaaacct tccatataat aagctatctg ctcttcctct
    38701 agtgctgcat atattgtaag tttattattt ccttttcctt gagtagtttg tggtgttgtt
    38761 gatatgcaac ttgtcataaa tgtaatcact acaatgcaca gacaagtaaa tataaattct
    38821 ttcatatctt ccccctttgt gttttttcct ttttttattt gttttttatt gtttttgctt
    38881 atgtttatat aatacaccta atttgttaat ataaagttaa gtgtaaatta acagttcgtt
    38941 aatttttaga aatttttgtt aaatatatta tttttagtta aatacagtct gtttttaaac
    39001 aatatattaa tttttatagt atctacattt taatttaaac ataaaaaata agtctaacct
    39061 ctataaagta gaatgttaga cttattttta taagtattta attatacaac caaatcattt
    39121 tttttctttt cttcaagtgc ttttttaagc accatatcct taaccttcat aagtctagta
    39181 gtacttgctc tctcattttc ttcaagcttc atagctatat acttaatagt ctcaatgtaa
    39241 tttggtatca ttacattttc aagagcatta acacgtctac gtgtcttttc tatctcttgt
    39301 gcaagaagct gtgcactttt ttcactttct gcaagtctta aaagtggttg catagcatct
    39361 gagaaagctt ccatagcaga atctaattca cctgatgtaa aagcaagacc ataaggataa
    39421 atatcacttt gattgttttc agttttaaag tcaaacacag gaacatcaac actcattata
    39481 tttctcgtag aaacatctac tgaaactgat tgctttggca tcataagtgc tgaacccaga
    39541 tactcctgac tcataactgc tcttgcgatt ataaagtttt tataagcagt atcaagagca
    39601 ttttctgctt cttcacgcaa tcgcttattt tctcttacaa tctcaagaaa ttgtttcata
    39661 agttcatcaa gtttatcttt aagaagctta tgacctcttg tagcagtttt aaggagtttc
    39721 ttaagtctag tcatttccat acgtgttgga tttatattta atctagccac agatatcact
    39781 ccttaggcat atatttttca aaatattcat cacggatacg tttaagttca ctttttggta
    39841 acatactaag aagcttccat ccgatttcta atgtctgctc aatagttcta tcagttctaa
    39901 atccttgtga aacatattct ttctcaaatt catctgcaaa cttagcatac attaaatcaa
    39961 tctcagaaag tgcagattca ccaagtatag ccataagttc ttttgcatcc ttacctcttg
    40021 aataagctgc aaaaagctgg ttcattgtat ctgcatggtc ttcacgagtc ttacctttac
    40081 caataccttt atcttttaga cgagaaagtg atggtaaaac atctatagga ggctgtatat
    40141 cttttttata aagttcacgg ctaagtataa tttgcccttc tgtaatgtat cctgtaaggt
    40201 caggaattgg atgtgtctta tcatcctcag gcattgtaag tattggaatc atagttatag
    40261 acccttcatg ccctttcatt tttcctgctc tttcatacat agtagcaagg tcagtataaa
    40321 gatatcctgg atatccacga cgtcctggaa cttctttttt agctgctgaa acttcacgca
    40381 acgcctctgc atagtttgta atatccgtta ttataacaag tacatgcata tcttgctcga
    40441 aagcaaggta ttctgctgct gtaagtgcca ttctaggtgt agatacacgc tctacagctg
    40501 ggtcatttgc aaggtttaca aacactacag aacggtcgat tgcaccagtt gctttaaaat
    40561 cgcttataaa aaattcagca tcttcaaaag ttataccaac tgcagcaaat acaacggcga
    40621 acttagaatc agttccacgt acttttgcct gtcttgcaat ctgaactgca agattggcat
    40681 gtggcaaacc agaccctgag aatataggaa gtttttgccc tctaaccaat gtattaagtc
    40741 catctatagc agagactcca gtttgtataa actcggccgg ataatcacgt gctgctggat
    40801 ttattggagc tccatttata tcaagtcttt tatctggtat aatttctgga cctccatcaa
    40861 taggtctacc cattccacta aaaacacgac ctaatatatc tggtgaaact ccaaagtcaa
    40921 gactctttcc taaaaaacga actttacttt cagcaaggtt tatacctgtt gagctttcga
    40981 aaagctgaac aagtgcagta tctccattta cctctagaac tttgcaacgg cgaatttctc
    41041 catttgaaag ttcaatttct ccaagttcat caaattttac accttctacg ccgtttatta
    41101 acataagagg accggctacc tcttgtattg acttatattc ctttatcata gttcttcagc
    41161 ccccctcttt ttaataaggt ctgcaagctc gttatctatt tcatcttcaa ttgaatcgta
    41221 agctgcatct atatcgcctt cttctacata cttagcacga ccaatctttt caagaactga
    41281 aagcttgata atatcgttta tagtaacatt ttgcttgata gcatcttgtg ctgacttata
    41341 gaattttaat ataagtccca tcattctata ttgtttatga agtgatgtat aagtatcaac
    41401 ttcatggaaa gagttttgat gaaggaagtc ttctcttata gaacgagtaa cctctagtat
    41461 caatctatct ccatctgaaa gtgaatcaac cccaaccaat tgaactattt cttgaagttc
    41521 agattcaact tgtaaaagtt tcatagcttg agctctttga gctgagaaat tatcatttac
    41581 atttttatct gcccatacat caactttttc ctgatagagt gaataactag tcaaccagtt
    41641 aattgctggg aaatgacgtt tatatgctaa agatgcatca agaccccaga atacttttac
    41701 tatacgaaga gttgcttggc tgacaggttc tgatgtatca ccaccaggag gagaaactgc
    41761 accaattgct gtaagtgttc cttctctttc atccatacct agacaattta cctttcctgc
    41821 tctctcatag aattgagcaa gacgtgaacc taagtatgca ggataacctt cttcaccagg
    41881 catctcctct aaacgaccac tcatctctct aagagcctca gcccatcttg atgtagagtc
    41941 tgccataagt gcaacactat atcccatatc tctaaaatat tcagctattg taataccagt
    42001 gtatatagaa gcttcacgtg cagcaaccgg catatctgat gtatttgcta taagcacagt
    42061 tctttgcata agtgactcgc ctgttcttgg gtcttttaat tcaggaaatt caagaagaac
    42121 atctgtcatt tcatttccac gctcgccaca gcctatatat acaactatat ctgcatctgc
    42181 ccatttagca agctgatgct gtgtaacagt ttttccactt ccaaaaggtc ccggtatagc
    42241 tgctacccca ccttttgtga ttgggaaaaa tgtatctata actctttgac ctgtaacaag
    42301 aagtgaatct ggtgttttct tttctctata tggtctttct tttctaactg gccatttttg
    42361 catcatagtt acaggtatat cattaccttt ttcatctgta ataacacaaa ctgtatcttc
    42421 aacagtaaat tcaccagaat atatttcttt tatagtaccc ttaactccat aaggaaccat
    42481 aattttacat tctactactg ctgtttcttg aacgccacca attatatctc ctgctacaac
    42541 cttatcacca acagattttt taggtttaaa ttcccactta gttgttctat caagtgaaga
    42601 tacttcaaca cctttagtta tattagtacc tgaaatatca tacatttttt caagtggacg
    42661 ttgaatacca tcataaatag ttgaaataag acctggtcca agttcaacac tcataggcat
    42721 tccaagagaa actacttctt cccctggtcc tagaccggaa gtttcctcat aaacctgtat
    42781 agaagcttta tctccatgca tttctataat ctcgcctata agatgtttat ctgaaactct
    42841 tacgacgtca aacatattcg catctctcat gccctccgct acaacaagcg gtcctgacac
    42901 ctttacaatt gtgcctgttt tcatattctc tcacctgcaa tcatatactt tatcaaaatt
    42961 taaatattcc ctcctatatt ttattagcac atatatttag caccaataaa atttgagatt
    43021 gtcttttatt caactttcat ctattcttta aataatatat ctgcacctat agcacgttta
    43081 ctagattctc ttacttcatt catacctaat cccatacttc ctccaatacc tggaataact
    43141 ataatggcag gaagttggta atctttgtat tttgctattg attcttttgc aagcaatgat
    43201 gcctgttctg taatataaat tatcgcatat tcatcttcaa ccaacttatg tatacttttt
    43261 ttaatttcgt cactatcata ggctgggaag atatctattc caagagctaa aaatcccatg
    43321 atgctatctt tatctccaac tactcctacc ttatacataa gcatccctta gcctttcttt
    43381 tatagtatct gcgtctatat tattaagctt actagtcaaa ataattctaa ttgtttttat
    43441 ctctgattct ttagcatata aatatgcaat tagtggttct aatgtaagag gcttaaattt
    43501 tgctcctcta acatattcca taagatagtc atcacaaagt ttttcaaaga cagtaaaacc
    43561 actatccatg ccatttttac agacatcaga gtaagaagta gatttaaaac atgatgctgg
    43621 agtatctgag gaaaaagctt ctaagaattt ttccttatca agtgagccac ctgaaacaaa
    43681 cacattcata aacatatcaa aatctttctt catatttttg actcttataa aactctttag
    43741 atttgttaaa tcacaaactt tcataacata atctattaca aatttgtttt ggctttcttt
    43801 agcagtttct ttcatactgg taaaggttgc tttatctaga acaatatcaa ccatctggcc
    43861 attttgtgtc ttattataaa catcaaatgc ctctaatata gctgatgaca ttatcttagg
    43921 taaatcacta aaactacgat ttgctaaaga ttctctaagc ttaataagag gaattgtacc
    43981 tccatcaatt aaatatttct caccatctac accagaaatt tcttctttaa tcagcacttt
    44041 taaattgtga tagtcatttt tataaagaaa tacatcaaca aatttttctt caggagctag
    44101 acttttaaga atttcatatg tctttgataa ttcttgagtc aaaatattct caaaattatg
    44161 tatattatta tttgatgtat cagcataacc tgcctcagct ataattctta aagagtcttc
    44221 agggcttttg gcttctgcca tttgaataaa catttgtctg ttaagaagct gtttttcaag
    44281 cactcttatt cgtgcaacgg catagggata agttttttct tctgccattt tttaacccct
    44341 ccttaattaa acaaaatttc tgctgcaatt tgttcaatat attcatgctc tactgcaatt
    44401 atggcttcaa atgaataatt gtactcaatg tcaccttttt taactatgaa acctccagta
    44461 atatctctag tttcatcaga cactttaatg cctttttttg atagcacatc ttttaatgtt
    44521 tttttatctt ttttagataa tactatctct gaatcatctg tacaatttga tttttcaatc
    44581 atgtttagta taatctcttc atattcatta tctttaagat ttaaaagttt gtttttagct
    44641 tctaaaatta cctcttctaa aatctcttgt ttttttgata atatttgctt tttagcctcc
    44701 atataagctc ctgatatttc cttagaagcc gctttttctg cttctgcctc tgcaagcttt
    44761 gtataggaag ccatttcctt ttcagctttt tcattagctg aatttacttt taaatctgct
    44821 tcacttttag ctttatccaa tatttcttgt gcttcttgtt tggcatcagc tataattctg
    44881 tcaatcattt tttgttcatt acccatagga gtgcttcctc cttttcattt tttttactta
    44941 tgaattataa tttataatta accaattgca attccattgt aagctaagaa agaaacaagt
    45001 agtcctaaaa gagcatatgt ttcaactatt gctgcaaatg ttatagcttt accaagttct
    45061 tcaggtcttt ttgcaactat tccaactcct gctgctgctg ctttaccttg tgctatacct
    45121 gatactaaac caactaaacc aattggaagt cctgccataa gaagttgtaa accttgagct
    45181 gatgttggta ttgcatctcc accaataatt cctgcttttg ataaaataag gaaagctatg
    45241 ataaatccat acagaccttg tgtaccagga agaagttgta aaactagaag ttgaccgaat
    45301 ttactagggt cttctgttac aacacctgct gcggcttgac ctgctattga agtaccttta
    45361 gcagaaccca tacctgcaaa taatgctgct atagcagctc ctgatattgc caaaaattga
    45421 ccatttccta acgcgtttaa aaattccata tttacatctc ctttttatta atgcttgtat
    45481 attttgtttt atacttaaac ggaacaaaag gaactcctcc gccttcataa aacttattga
    45541 aaaattctac atactgtaac ctacttgtat gaacatatgc acctagtgca tttataagaa
    45601 ggtttattgt gtgtcctaca acaccaatta caactgcaag tatcggacca gctatagctc
    45661 ctaaaaggtt gataacttgt gctataactc ctgttgttaa acaaagcgcc ataattcttg
    45721 tataagataa tatatcagca aaataacttg ttataccata gagacttgaa aatcctttaa
    45781 aaagcttaac aggaatacct ttaaagcttc ttccttgagt aagtacaaga cctatagcac
    45841 ctataattgc taaatatttt cctacttctg aaaatacacc tatatcccct gcaacaaaag
    45901 gtattataag tagacataca cctgttatac acaaatacca aaaacctatg tcaaagattg
    45961 catctattac ctttccactt cttattaatg tatatgcttt tattcccaaa cctacatata
    46021 tatggataat accgaacagt aacgacattc ccataagtgt cataacatcc tctaaaggat
    46081 taattaatgc ttttatagga attaaatccc ccaaaatacc cccgaatata agaccccata
    46141 cagtagttga aactccacag ataccaataa gtttaattaa atttccttca cctttttgta
    46201 tctttaattt atatacaaca aatccacaga ctactgcaat tattaaccca tatgcggcgt
    46261 cacttagcat cattccaaag aatacaacaa agaagaaagt taaaattgta tttgggtcaa
    46321 tatcttttgt acttggatag ctgtacatgt tagttacact ttcaaaaggt gttactaatt
    46381 tattgttttc aagcagaatt gggaagcctt cttctttact tccttcttca gtctgaacac
    46441 aacaattaaa cttttctgta atttctttaa ttaattcatc tgcccttttg cttggtaacc
    46501 aaccattaag acagaatgtt gtttttgttt tgacaagtct ctctataatc tttttttggt
    46561 ctctttctat agtgtaaaaa tcatataggt tttcaagcat gtgtatacta tctgcatgtc
    46621 ttttaatttc ctctgttttg tccttagaaa cgttttcctg tctaattatc atttcattgt
    46681 atttcttgat agcttgtaac ggtgtacctt cttcatttgg taatgaaacc actgaaaaat
    46741 taaattcttt taaaacttct aaaacatcat caaaagtttc ttttaaagta attaaataaa
    46801 catagttcat taacttgtca gaattgacaa tcccaataac actttctggt atttcatctt
    46861 ctaattttac tcttaaagca tcaatgtttg cgcttatggg cacagttcca agtatagttt
    46921 ttgtatactt agtttccata ttttcaagag gaatatcaaa gttcacccat ggttctaaca
    46981 tacttttatt gttgttaagt aagtttatgt tagaccttat tgtacctatc tccttgtgca
    47041 aattgtttaa ctccagagct tcagcataaa cttgcccttc tttttcacta tcaattttgt
    47101 taaactctct ttttggtgca agtagggatt ttttttgttt cactagtgaa gaaacaatat
    47161 taattgcttg gtttacatga gacattttct gctctagcat tataacttca gattcttcac
    47221 tatcttttac aagataattt tttaattcct cctcctcagt aagaaaggca ctatcatcaa
    47281 tctgaacaaa cccacggttc ataagtagct ttaaaatctg gcttttttga gcttctaagc
    47341 caacaataga tattttgttc atattaacta ttgccatatt atctcactac ctttccaata
    47401 accgcttcaa tagccttact ttttctttct tcagcagttt tttcaatttt cagacattca
    47461 cttttagcat tagctaagat tttatcaacc tctgctctac tgtcggtgac tgccttctca
    47521 ataagagttt cttccataag ctttgcttgt ttttttacat cagcaaatat gctttcacat
    47581 ttgtttacag catcagctct gatagactct gcatcagtaa cagcttttac tttgatactg
    47641 tctgctgtct gctctgcctc aacaatgctt tttattattt caaaagccat ccaaatcacc
    47701 tctcttacct ttttactatg tatataacca attagatttt tttattctaa ttagattact
    47761 acctcattgt taaagtataa acagcatttt tatataataa ttaatatttt tcaacgttta
    47821 tttcttaata aaacatattt tagaatagta cttgcctaga tttacatcct tttttgactt
    47881 acttttagac tatgacatga gtatggtttt taaataccat tattttcaat aattataatt
    47941 taaagcgata tagtttgtca atagcgttat tttgttttaa aattaacgtt atgtcgacat
    48001 tttaaatttt tattttattt tttttataat tttaatttaa tttattacat ataaaagttt
    48061 tttatattct ttttcaacct ctaaccattg aagtttattg ttttttttga atttttagaa
    48121 atatctcgca ctattttatc taacttttat aaatcatcaa gctatatcga tttttgtcac
    48181 cttattttta atctaatttt tttatatcta gttagaaata aatcaatatt tttaaagatt
    48241 gataaaactt acacctagtt ctaatagttt tattttaagg caatgtatta atcttaagta
    48301 gataatatca ttagttactc tatatattcg acaacattat aaaaaaatcc tcgtaccaat
    48361 cactccaatc ttcaatagga tatgctgctc ctccatttac acttttcagt agattggatg
    48421 tatattcttc tcccatagaa aaaagttccc ctactgtcat atcataacct ctagatgtaa
    48481 caaccttaca aaatgaatcc ataacatcac gttgttctct tgtttttata agttcttttc
    48541 taaattcatc atcattctta gcttcttcta aaattttagt taatttttca ttcattatgt
    48601 atttctcctt ttaagtagtc tttctgtaaa cttcaataag ctttatataa aaaggaagcc
    48661 atcctaaata aactaagatg acttcgctta actgttagca acacatttac tagtataaaa
    48721 taattggtgt acctggttct atattttcat atattttctt tgccttagaa aaaggtgtat
    48781 ttacacatcc atgtgaacct gaagacttat atatacttcc accaaaagaa tttctccaag
    48841 tagcatcatg aatgcctatg ttcccattaa acggaagcca ataacttaca ggtgaactgt
    48901 aaccttgacc agttaatgaa acatttctag ccttataatt aagaggatat atacctgatg
    48961 gtgtagcaaa tcctctagct aaatcacctg ttacaacgtc tgttgataca agcatttctc
    49021 catttttaaa gaaccacata tgttggccag aaagactaat ctctacatat gtatttccaa
    49081 tatcatcttt attacgagat acagcttttt gtatgtaaat aggttctctt gtaacatttt
    49141 taccagcttt tacaacatca actaatgctt cagcttcttt ctttttatct atcaaccaac
    49201 cataaattcc acctgaaatt gtaatatctt tacctgtggc agttttaaat ggtcttgagt
    49261 caccaaaagt actgtatttt ttacttaaac ctcttgtata ttctaccata gcatcattat
    49321 caaaagttat gtcataattc ttttctgagt ctacttttaa ccatttatta atttcagaac
    49381 catctaaagt ttccttacgg tcactaaaat catatgtaac gactacacca acatacttat
    49441 ctaatgtctt aatagcttgt ttcaactttt ctgaatcctt tgtgttgttt ggtgcttcat
    49501 aaactttact ttcatccaga gaaatagaag tattcccaga attaattgag ttttgtacta
    49561 acttataaaa atcatctttt ttcactttgt ttccaagtac ctctggtact ataacataag
    49621 cgtttttagt gctatcatac ttaggataag cactcttagg ttctacaaca tttttactat
    49681 caaaacaaga taaagcatta aacctttttt ctagtaaatc tttattatat gaaagagtta
    49741 tcatattatt atactcttta gacttaaata ttccaccaat ccatccaata gcgctctgac
    49801 tatcttttat cttttgaact ttatcatctg gtgtaaattt taaatcaata tcttttgctt
    49861 ttatttgttc tttcttattg tttctttcct ctaagtttaa agtataggaa ttagtactag
    49921 atgttaacaa atcatttact tgctcaactg tttttcctga agcctttacg ccattaatag
    49981 tcgttccaaa gtaaaaatga tttctaaaaa agattgccat tcctatataa gctacaaaca
    50041 aaacacctac tactatagct atcttaaatt ttagattttt ttgtccactt tcttgtttta
    50101 cctcttttcc atcaatcata attaaatcct tccttacatt gtaattacct atgtacctta
    50161 ttggttttta aacaaaacca tgtatgcctt attttatata cccaaattac tgtatcatta
    50221 tttatatttt taaatatata gttatttcta taaaaccatt ttatctttta gataaaatga
    50281 ttattataaa tccccccttt caaaatccct taaacacaat ctctgctata ttaatatatt
    50341 accatacttt taataatcgt gggactatct atctattttt gtaacactaa actactattt
    50401 taaaaaagaa actaattttg tgttagtttc tttatcttaa cttattttta tattgaattt
    50461 tagcttaaca taacgttgtt atatagattc tatttaatta ttttagtttc tatatctttt
    50521 ccatctgcat attctttaag taattcctta gcatatccaa aatattcttc aatatcagat
    50581 tcttgactaa aagaaaatat acaaattaat atttcatttg catcttctgt tatcattgct
    50641 ctttcagaat cactagttgg actcccaaat ttacccactg aatcagataa tataggaaga
    50701 ttttctatat ttattaattc tttcccaata cccttatact gttctccttc atctcctaca
    50761 gtaaaacata ctggtgaatg taatttgctt acattatatg tacctactgg atataatgat
    50821 tttattgata ttaaattgtt tatttctact atattattta ttgtataaag acccttccct
    50881 tgaataattc ttctaaccaa tgcttctgaa gatgttctat atctacttgg attttttcca
    50941 agctctttat aagcatttct tgcatcttta attttatcta gtttcgtaat gtcttcaact
    51001 tttagacttt gatttatagt atcacaaaac tcatttattt cattaattaa tttttctgag
    51061 cttttattta ctgctacttt tgcttgaatg caacccagct tagcattagg ccatctttcc
    51121 ttaagtttgt catcaatact tatatctatc atacttaaac aactcctata cactaaattt
    51181 ttattaaagt ttttatcatc tatacattat agtactattc ttttgttaat aacatgttta
    51241 ttagcaaaat aaatttattt ttaatataat ttttataaaa tacaattatt ttttgcttta
    51301 tattagacaa tacattgata aaataaaaaa acactaatta tttagcaatg atttattaaa
    51361 atcaagcatt cataatagtg ctttatataa aaatcaaatt ttgttttaaa gtaaatctaa
    51421 aaaattctta gctggcattg gtcgtgcaaa ataaaatcct tgaactaaat cacatccaaa
    51481 ttgtttcatt aactcagctt gttctttact ctcaacacct tctataatta caactaaatc
    51541 tagtgatttt gctagagaca ctattgattt tgctatattg cgacttctct catcatgttc
    51601 aatgccacca agaaaagact tatctagctt caatatatca attggcatat ctcttaaaca
    51661 actaatagaa gaatatcctg taccaaagtc atccatagaa atagaaaatc catacgtcct
    51721 caactcattt aaaacattct ttaaaatatt taactcatta atagccacag tttctgttat
    51781 ctctatttca atgaaatctg aacttaaatt atacattttt attgttttat tgataaattt
    51841 tacaatatct ggttgataca actcgaccct agataaattt actgaaactg gaactatctt
    51901 tttaccttgc tttttccatt catataaatc attgcaaacc ctttcaaata caaatctccc
    51961 aatttttaaa atcaacttac ttttctctgc tattggaata aatactgcgg gacttataaa
    52021 accatgttct ggatgattcc atcttattag tgcttcactc cctatcattt ctccagttac
    52081 aagtgaaaac ttaggttgat aatacacttc aaattgattt tttaccaatg ctatttttat
    52141 atcatctaaa atcattgatt cctcactaag cttattccta acatcttcat tataaatagc
    52201 ataatttata tttttacctt tagcaacaga cctagccata tttgctttat ttacagcctt
    52261 ttgaatatct acttcacctt cttcaacaaa ataaataccc acacacagag aaatttcaaa
    52321 gactatactc aaattacttt caatattact tcgtatatta tcaagttttc ttataatttt
    52381 atttcttcca tttttataat cacagaaaat tgcaaaataa tcacttgaaa gtcgtgcata
    52441 tacctcacct tctgttaatt cttcttttaa agcttttgct attgtaatta ataaattgtc
    52501 accaaattca tatccaaaag tatcattaat catcttaaag ttattaatat caaaatatac
    52561 tataatataa tttaaagatg gtttatctaa aagatactta ctacattctc tataaaattt
    52621 attttgattt cctatatatg taactttatc ttcataagcc aaacttaata tttctttttc
    52681 attagatttt tttatataaa ttatataaaa aataattgca ataaatatta atacaataga
    52741 taacactgca tatacagctc tgttgattat ttgttttgaa ttactaaata caacagtttc
    52801 tggaattgaa aaaattaaat tccagtcttt tatataatta ttttcactat tcccattatc
    52861 catagtggca tatcctaaat atcttctttc ttccaacata tttaatacag ttgcacctgt
    52921 tttattttct tgcaattctt tttttaatct atttacttct tgaatatcat tatcctgttt
    52981 taacaattta taaatatttt ttgataggct atccccttgt ggatgaagga taattgtacc
    53041 attatttttt acaacataag atatactatt attttcataa aaagatatat taataagttt
    53101 catcagagta ttgatattgt aagtacaata taaaactcca actactttat cattatttaa
    53161 taatggtact gaaatagcaa tcttctttat agacttattt acttcatcaa catatggact
    53221 tgaaacatac ttcttacctt taattgagtt tttgaaaaat tctctatctt tcactgaaaa
    53281 cttatcacct ttggtatttt cagcattacc atttatatca actattgcca tagtgtaaaa
    53341 tttttgattt tccatttcat ctaaaagatt tttcattttt tcctcattag gtatatctgg
    53401 atttgaagca taatagttag aaaaaatatt taaaacatct aaatcttttt caatttgtct
    53461 ttgtgctagt tgagagcctt gtactgcaac ttcttttata tgtatttttg cctctgacat
    53521 aagaagatgt tttgtatctt ctatatagat ataccccatt gtcaaaaata atgatgttaa
    53581 aaaaagaatt gtaattaatg taaaactttt atttctccct gtcattcgac tcctccccta
    53641 attagtcaat acttcatata gataatatat cctttttata ccaattcatc atttatattg
    53701 tatataacta ttcttaaatg ttacacataa aatcaacata ataaccataa aaacattctt
    53761 ttattattat aataacacta tttaattgaa ttttaaatta aagaataaaa actatccatt
    53821 ttctcaaaca aaaaaactct tatacaataa aactttgttt tatgtataag agtttttatt
    53881 ttatctattt tatagcaaac ttatcttcca taatatgaat ttaaatacat atcttttatt
    53941 tcattcataa gtggatatct tggatttgct cctgtacatt ggtcatcaaa tgcttgaatt
    54001 accatttcat ctattgaatc cataaactta gattcttcaa cgccaaactc ttttatagat
    54061 ttaggaatac caactttaag ttttaaatct tcaatagcta ccaataaact ttggaatttc
    54121 tcttcatcag aatttccttt taatcctaaa aatgaagcta tttcagcata tctctttaat
    54181 gcttctggat atttatattg agagaatgct cccattttct ttggtgcatc tgaagaatta
    54241 aatttcataa cttctgttat caaaagagca tttgcaacac catgtggtac atggtggaaa
    54301 gcacctaatt tatgagccat agagtgacaa acacccaaaa atgcatttgc aaaagccata
    54361 cctgccattg tagaagcatt tgccattttt tctctagctt ctgggtcttt tgcaccatta
    54421 tcatatgcac gtggaagata ttcaaatata ctcttaatag cttgtaaagc taatccattt
    54481 gtataatcgg ttgcaagcat agatacatat gcttctaatg catgagttaa agcatctata
    54541 ccagaagcag atgttaagct ttttggcata ttcatcatca tatcagaatc aactatagcc
    54601 atatttggca tcagttcata atctgctaat ggatatttta ctcctgtatc ttggtcagtt
    54661 ataacagcaa atggtgttac ttctgaacca gtacctgctg atgttggtat agctacaaaa
    54721 ttagcttttt cacccatttt agggaatgta tatacccttt ttcttatatc cataaatctc
    54781 atagctaggt cttggaaatc tacatctgga tgctcataca atgtccacat tatctttcct
    54841 gcatccattg cacttcctcc acctatagat attattacat ctggattaaa ttctctcata
    54901 gctttagcgc ctatcttagc acattccaaa gttgggtctg gttctacttc aaagaatgta
    54961 gtgtacttaa tattcatttc atctaataaa tcagtaactg ctttagtata tccattattg
    55021 taaaggaatg tatctgttac aataaaagct ctcttcttat tcattacatc tttaagttct
    55081 tttaatgcta ctcctaaaca accttttttg aaataaactt tttctggtgc tctaaaccaa
    55141 agcatatttt ctctcctctc agctactgtt ttaatattaa gtaaatgctt aactcctaca
    55201 ttttcagata ctgaatttcc accccaagac ccacatccta aagtaagaga aggagctagt
    55261 ttaaaattat ataagtcccc tataccacct tgagaagaag gagtattaat taaaattcta
    55321 caagttttca tggctgaagt aaacttatca agtttttctc tttgatttac atcatcaata
    55381 tataatgaag atgtatgccc aaatccacca tcttctacta atttttctgc ttttctaact
    55441 gcatcatcaa aatcacttgc cttgtacatt gcaagtactg gtgaaagttt ctcatgagca
    55501 aaagcttctt ctatttcaac tgattctact tcacctatta aaaccttagt atctactggg
    55561 acttcaaagc ctgcaagttt tgctatagta caagctgttt gcccaactat tttagaattt
    55621 aatcctccat ttactaaaat tatatttctt attttttctg tttcatcttt atctaataaa
    55681 taagcaccac gctctttaaa ttcttttttg acttcattgt atatattttc taatactata
    55741 accgattgtt cagaagcaca tatcatacca ttgtcaaaag tcttagatac aagaattgag
    55801 tttacagcag tttttatatc tgcactatca tcaattattg ctggagtatt acctgcacca
    55861 actccaatag ctggttttcc agatgaatat gctgatttaa ccattccagg acctcctgta
    55921 gcaagggtca aatccacttc tttcataaca gttgtagtta attctaaaga tggctcatct
    55981 atccatccta ttataccttc aggagctcca gctaaaacag cagcctcaag aacaactttt
    56041 gcagcctcta tagtagaatt ttttgctctt ggatgtggag agaaaattat tccatttcta
    56101 gtttttaaag ctaaaagtgc tttaaagata gcagtagaag ttggattagt tgtaggtaca
    56161 actgctgcaa taacacctat tggttcagca attttagtca taccaaatgc ttcgtctttc
    56221 tctataacac cacaagtttt agtttcttta tatgcattat atatatactc tgaggcataa
    56281 tgattcttta taaccttatc ttcagcaatt cccataccag tttctttttg tgccattata
    56341 gctagaggaa ctctttgctt attagctgcc aaagatgctg ctaaaaaaat tttatctacc
    56401 tgctcttgac tatatgtagc aaatattttt tgagcttctc tgatttttgc tagtttttta
    56461 actaagcttt caacgttatt tacagtatct aaaccaactg acataacttc attttctttt
    56521 ttattttcta ttattacttg ttctttatga gccattttaa caacctcctg agatagtttt
    56581 ttatttatta tgttaattta ttaacattat agcatttact tttcctattt tcaagttatt
    56641 tttttaacat tttatttttt atctaatata acatcatttc tactaataat atctagcttt
    56701 acaaatactt aatttaacta gatatcactt tattttttac gcaaatcact aatgaaatca
    56761 tctaaaaact taaggataac gttatttttt taacgtttat atttttgtat tttttgcaaa
    56821 taaaacttta taaaaagaat ttttaatatg atactctatc aagtttaaaa ataaaaatcc
    56881 ttgaaaatga aaattaaaac ttaattaaca agttaaagta aatatagtta aatgtacaaa
    56941 catttacaac
//
LOCUS       DAEHWM010000015        56309 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.016, whole genome shotgun sequence.
ACCESSION   DAEHWM010000015 DAEHWM010000000
VERSION     DAEHWM010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 56309)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 56309)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..56309
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.016"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(74..919)
                     /locus_tag="KNP36_000943"
     CDS             complement(74..919)
                     /locus_tag="KNP36_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872832.1"
                     /translation="MIYIIEILKISVINIFCFIGIFIVFGLIFSITENLNNKFIFSSF
                     GKTGIIVTGAIGTFVHELSHLIMCLIFMHKINSVKFFRPIESKNDGILGYVSHSYKKD
                     NLYQSIGNFFIGIAPIIGGTIMIILIFKILLPDSYMKVTQNIDLKLYVSMINNLNING
                     FIHIILGDISNFIRIMLLTPSVYSLKYFIFMFLMYSISTHMSLSSADLKNSLNGLSFI
                     VIVIFVISSITYLFGFDNLNISSLIVKYNIFISFFMAIGFIFSIVTLIISYILSLVSP
                     FKNFS"
     gene            complement(949..1320)
                     /locus_tag="KNP36_000944"
     CDS             complement(949..1320)
                     /locus_tag="KNP36_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBF0872833.1"
                     /translation="MKLKLLVEEYAVCRLNNDSKIPTWIDTEKFYSITRTDDELSVVC
                     LNNNIPSDVKSEKEWRILKILGPLDFSLVGILSKLSSLLADNKISIFAISTYDTDYIL
                     VKEKDIENACKILSCNGYEVE"
     gene            complement(1473..1733)
                     /locus_tag="KNP36_000945"
     CDS             complement(1473..1733)
                     /locus_tag="KNP36_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003866776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein S"
                     /protein_id="HBF0872834.1"
                     /translation="MEVLKVSSKSNPNSVAGALAGVLRERGVAEIQAIGAGALNQAIK
                     SIAIARGFVAPSGMDLVCIPAFTDIEIEGDKKTAIKLIIEPR"
     gene            complement(1922..2866)
                     /locus_tag="KNP36_000946"
     CDS             complement(1922..2866)
                     /locus_tag="KNP36_000946"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit alpha"
                     /protein_id="HBF0872835.1"
                     /translation="MIENNSEKIKVLENDIKQLITISKANNIDLSDKINSLNEKLEKL
                     KEDAFSHLSAYEKVTLSRDIKRPTTLEYIEHICSNFLELHGDRLFKDDPSMVGGIGQI
                     GKFNVTIVGHQKGRDTKENIKRNFGMPHPEGYRKALRLMKQAEKFNRPIITFIDTSGA
                     FCGLEAEERGQGEAIARNLLEMSKLSVPVITFVIGEGGSGGALGIGVGNDVCMLEHSV
                     YSVISPEGLSSILFKDSSKAKEACDVMKLTSNDLYDLKIIDKIIKEPLGGAQKDVEAV
                     SKEIKAYILERLNHYKDMDKEEIIAQRYKKFRNIGKCL"
     gene            complement(2887..3741)
                     /locus_tag="KNP36_000947"
     CDS             complement(2887..3741)
                     /locus_tag="KNP36_000947"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HBF0872836.1"
                     /translation="MIKKFLSSKESKYVTISLDDNFKKNSVDDKFWTYCKGCDSHVFR
                     KDIEENSFVCPKCSRHYGLRARKRINLLIDKGTFMEFNSDVEFQNPLNFPKYKEKVDS
                     YKEKTKESEAVVTGYGRINGIKTVICVMNPDFMMGSMGSIVGEKITYSIEYAAENNLP
                     IIICSASGGARMQEGMVSLMQMAKTSQALSKLEEKSLPYISVLTDPTTGGVTASFAML
                     GDIIISEPNTLIGFAGPRVIEQTINQKLPEGFQTSEFLLEKGFIDMIVDRRKMKEVLY
                     QILAMHKK"
     gene            complement(3756..5117)
                     /gene="accC"
                     /locus_tag="KNP36_000948"
     CDS             complement(3756..5117)
                     /gene="accC"
                     /locus_tag="KNP36_000948"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HBF0872837.1"
                     /translation="MIKKILVANRGDIAVRIIRTCKELGIKTVAIYSEIDKDCFHRYI
                     ADESICIGPNNISKSYNNIENIIYLALKLKCDAIHPGFGFLSENPEFAKQCEDNNIIF
                     IGPTREQMILMGDKSRARETMMELNIPVVPGSESVLKTKEEALEVAREIGYPVMIKAS
                     SGGGGKGMRIVRKEEELFSNFDMASSEALAAFSNSDLYMEKFIENPRHIEVQVFGDKH
                     SNAIHLGDRDCSMQRRNQKVIEESLSPYLSDEERQKLHKIAVDIVKGVGYIGAGTIEF
                     IVDKDKNFYFIEMNTRIQVEHPVTEMVTNLDLIKLQISIANGDKIPFKQEDITFRGHA
                     IECRINAEDSSKNFAPSPGKIESLNLPGGFGVRFDTFVYAGYTIPPLYDSMIGKLICW
                     AETREECISRIYRALDEIIVEGINTNVEFQKALVTSEEFREDTHHTKFIEDVFMKKEF
                     ATL"
     gene            complement(5133..5585)
                     /gene="accB"
                     /locus_tag="KNP36_000949"
     CDS             complement(5133..5585)
                     /gene="accB"
                     /locus_tag="KNP36_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HBF0872838.1"
                     /translation="MNINEIKELLKAIDSTNLEYVKLESSDLRLEVSKKAQSTSSPVL
                     SVQQESVVDLSLEKPVVNDTPVTSNENLSVVVAPLMGTFYDSPSPDADSFVKVGDVVE
                     EGDTLCILEAMKLMNEITSEIKGEIIEVLVSNEELVEYNQPLFKIKPL"
     gene            complement(5855..6301)
                     /locus_tag="KNP36_000950"
     CDS             complement(5855..6301)
                     /locus_tag="KNP36_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872839.1"
                     /translation="MESKFFNWYTQSLGGTFGIISCICAYLNGYMFVYTNSASKYFES
                     IGFLGIISSYTLLPLCMLTLIFGVIYSYTPETSDKSIFNIPFFTLNKRLILITVVFGF
                     IGARVYFIIPAILITFNLYSNVLIAKLKYILCKNKENDTNLKESEV"
     gene            6576..6854
                     /locus_tag="KNP36_000951"
     CDS             6576..6854
                     /locus_tag="KNP36_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424072.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872840.1"
                     /translation="MVDTLEFGLKILFFILSIIWMGKIMILRTDKQIVINPLLIGISA
                     ILVMLHTSQSNIEFFGLDVQYIRIVLYIIYSLIILIGIWATNRRNGIF"
     gene            complement(6983..7729)
                     /locus_tag="KNP36_000952"
     CDS             complement(6983..7729)
                     /locus_tag="KNP36_000952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872841.1"
                     /translation="MWEGTMNLANLIPFIISAAALSPINSNDKVLSENQLKDIFPDAN
                     LRAVVKRYINPDEMTISNIKALDGEFYATGESISNLKGISYLENVDNFIFWNNNIKEV
                     PKEALSLKDMDSINLANNYLIDDDVVNSLSHNGVDVNCDLNFIDTKDNQYKLDSKYHN
                     VDIAKGESIDLRKIITKKIDSYYKYWEVTDNLPKDLNFIVSVSDKSVLSCEDMIIKGN
                     KTGKAVVKVILSDKNDLNTSQEVLITVNVK"
     gene            complement(7858..8502)
                     /gene="trmB"
                     /locus_tag="KNP36_000953"
     CDS             complement(7858..8502)
                     /gene="trmB"
                     /locus_tag="KNP36_000953"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HBF0872842.1"
                     /translation="MRRRRKKGADEKLLSYTKYVLRDDIDKLKGKWNLKFRNDNPIHV
                     EFGTGKGKFITTLAKQNPDINYIAMELKEEVLLKAVEKADASNLNNILFLWGDVSNIL
                     DYFEAKELSRIYINFCDPWPKNRWSKRRLTHSGFLEMYNRVLEDDGEIHFKTDNEKLF
                     EFSLNEIAANNWLLKNISLDLGNSEYENNVTTEYEDKFMSQGMRIFRCEAKKRN"
     gene            complement(8640..8960)
                     /locus_tag="KNP36_000954"
     CDS             complement(8640..8960)
                     /locus_tag="KNP36_000954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein HesB"
                     /protein_id="HBF0872843.1"
                     /translation="MKITLPETAIDTLKSILKDNQDKPNNIRVYFAGVGCGGPSFGLA
                     LDEKKEDDLTYEVGELQFVMSSDEYSQYGDIIIEDTGFGFRVIPENMKDQGGGGCSGC
                     SGCH"
     gene            complement(9413..9661)
                     /locus_tag="KNP36_000955"
     CDS             complement(9413..9661)
                     /locus_tag="KNP36_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBF0872844.1"
                     /translation="MQKTKAWGIIEPEKPESQQQMAHMDFAVKDLEEAVQYAIHCGAT
                     IAEEQFTDDWRVMIDPAGHPFCLCQMKSIMESSHFSLL"
     gene            complement(9692..10153)
                     /locus_tag="KNP36_000956"
     CDS             complement(9692..10153)
                     /locus_tag="KNP36_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase/bleomycin resistance/dioxygenase
                     family protein"
                     /protein_id="HBF0872845.1"
                     /translation="MKFGGVLLIVKDINKSKKFFEDVMEQKITLDLGEHVSFENGFGL
                     QSNYKAIIGYDLPIYQQSNNFQLYFEVNDIKQWESKINRIGNIEFLHYIKEYPWGQRT
                     FRFYDFDKNIIEISESMESVIKRLLKQGLALEEISKRTMYPVEFITQFQQV"
     gene            complement(10191..11024)
                     /locus_tag="KNP36_000957"
     CDS             complement(10191..11024)
                     /locus_tag="KNP36_000957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872846.1"
                     /translation="MLKKESIHFINKNRSLIVCEDNFVYLLPCIQLRNWISNFTISFP
                     NQTIISDNYTIIPHGSVTLVFFYDATGLHSLLFGPTTKPKTVGNIANRCDVILIIEFQ
                     PAGFFPLIGIQQSELIDKVVPFSIINTSLDLEIKKIFNESLSIDKLILKLEELLISNI
                     KIEYSYEFILAIQLIIQNSGNISSQEISKKVFYSSRHLNRLFNQYLGLSMKSFSRLVR
                     INKSIKLLNNNKTSWMSICNELGFYDIPHFIKDFKIVCGITPQKYRANMSDFYSEIAK
                     F"
     gene            complement(11298..11984)
                     /locus_tag="KNP36_000958"
     CDS             complement(11298..11984)
                     /locus_tag="KNP36_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872847.1"
                     /translation="MKITHNSLAVEAKNIIKEYKIGNTTTRVLKEVSLQVMKGEFVSI
                     MGQSGSGKSTLLYILGGLDTPTSGKVYMNGADISHFNDEKMSIIRRRNIGFVFQFYNL
                     IPNLNVEENIMLPLLLDGKNLKDYKNQLDEILDIVGLTDRRKHTPRELSGGQQQRVAI
                     ARALIGKPEILFADEPTGNLDSKTGIEIIDLLNKINRDNGQTIIMVTHSPEAAKSSSR
                     TITVSDGLIV"
     gene            complement(11999..14476)
                     /locus_tag="KNP36_000959"
     CDS             complement(11999..14476)
                     /locus_tag="KNP36_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0872848.1"
                     /translation="MKIILKYIFTNIKERKIRTAVMLLSIVLSTVLLFVSFSIGLSYE
                     SAQRKMAKGMYGTATISVQSKNPDILTNLEDIPDLNTIKSKVGVLESSAIYNKGGYYE
                     EFSLISADLSQLNKINKPRLENGDSITDFSGDKIILPNRFTSKYKIKKGDSITLQIYG
                     KSYTFQVSDIASYDTVFLRNTRGVNALLPKETLSKIINKGSGYTRVLIESEEEITENL
                     VNKLSEELSTEKYMVSNTINETKIISDARQKTMPFFLISFFALTLSIFIIYSSYKVIT
                     LERLPFIGTFRSIGANEKTVTRILMLESILYGSIGGLIAIPIGVVVLNLMLHGLGNSL
                     EQGISIPVVISPIGVIISVIVAIIVSSFSAYIPVKKASHLPIKNIVLGTVEEKNVSNR
                     SILFIGSIMFILSILLPRISPENTLYLAGGFSLLGLIVATIVLIPLITDIMSIVFEFV
                     YKNILGNEGKLAARNMKNNKNIIQNITLLFISISAVIAISVVGNFVKTYITDVFRDAE
                     LQGFADGNMNEEFIEDVRHMEGIKKILPLYVMNNEISGNGVTLSRLEGTDNIKLYNSM
                     FGINYTNFEIKKQVIEAFNDKRSVILNEDTLKKVGLSIGDTITLSNDKYDFSYKIVGS
                     FKSRANDVEAVIPSHYAVNDFDKTNYGFLVYTAVNPDAVMIQIRYLFGDTYNWSRTVE
                     EFNNDSLNTISSFLSPMNKMTYFIFLLATVGIINNLLINYIQKRRSIAMYKSIGLSNK
                     QNIKVTLIEGVTSGLLGAVIGIVISILEIQTIFIVAGPKISMKPDLDFKTFIIVGLLG
                     IIVTLIGSIVPIIKGKKMKLIEEIKFE"
     gene            complement(14695..16098)
                     /locus_tag="KNP36_000960"
     CDS             complement(14695..16098)
                     /locus_tag="KNP36_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872849.1"
                     /translation="MHKPSYKTVFHSYIIFFMIFICLILTVIGIFLSLITIQKPNGEF
                     IRSDWPKKFTENFNEQIVFIDNKPQVKQSGLEKLRENQLWLQILDSSGNRVYGFLEPK
                     EHKDYYSNSELLALANQNNSSNGTVYFNTIKNNKNDYIYIIYFPLNISKVNMFFDGGK
                     FIGGKSIVFSIIGIIFLIILVSGIAYGYWVTKCISNITSAVSDISKRSYLPVNIKGVF
                     ADIYNSLNILNEEIHKSDEIQNKTDIMREEWISNITHDLKTPLSPIKGYAELLTDSST
                     NYSPEKVYKYASIMLKNIEYTNTLINDLKLTYQLKNGIIPLNKNNYDLVRFLKELSID
                     ILNYPEYESNIVEFKSNIDNINFDFDCTLLKRAFSNLIVNAFTYGDKNTKVCVHVTLN
                     ERIEIIISDNGKGMSREEASNLFNRYYRGSNTKQKIEGTGLGLAITKQIIEVHGGNIS
                     VESIPGLGSSFYITFPI"
     gene            16597..17457
                     /locus_tag="KNP36_000961"
     CDS             16597..17457
                     /locus_tag="KNP36_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBF0872850.1"
                     /translation="MKKQKSPILLEMLGLFFGCISMSIGINMFLKPHTIAPGGLSGLS
                     LVLNKVTGLPVSAIMLIIGVPLVILAFRIMGTKNSLKTLFGTVVFSAIVQLTDPLSKL
                     RFTNDLLLSSIAGGILVGIGLGIMFKSDASTGGTDLIALILSKKFPGIKATKFMSCLD
                     GMVVISSGIVNRSLETALYSGIALCVLIKIADMIMEGFDHSKAFFIISDEPESLRQAI
                     TEELDRGLTILDGKGGYTRENKEVLLVVVSKKQELYLKRLVKRTDPTAFVIVTDVHEV
                     LGEGFKNLEN"
     gene            complement(17696..18253)
                     /locus_tag="KNP36_000962"
     CDS             complement(17696..18253)
                     /locus_tag="KNP36_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0872851.1"
                     /translation="MSDSEYPQMKTLETRSCILRPASLDDVEDFFDCYKNKIVVKHLP
                     FSEHKSLEDTRKFIKSFFLNPYKKGKIGHFAIVYKRDNKVIGNMGFNNINPKALEAEI
                     GICINPSYWGHDFATEITKRVIQYGFRELNLNKIIAITYEENQNSTKSLDLLGFKCTG
                     KYIKKIHTGNTVKNVPCYQYELKKQ"
     gene            complement(18443..19330)
                     /locus_tag="KNP36_000963"
     CDS             complement(18443..19330)
                     /locus_tag="KNP36_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0872852.1"
                     /translation="MNIKLELYKVFNAVVNNKSFSLAAKELFMSQPAVSQSIKQLEEQ
                     LDTLLFYRNNKGVKLTPEGKILSEHVTTALKLISSGEDRINKFKKLEYGSLKIGVGDT
                     AARFFLLKYLEIFHKKYPHIHVSTINRTSRELISLLKDGNIDIAIINMPIEDDTLNIV
                     ECIEIHDIFVCANDYIEYKGRKISLEELNTLPLIMLENKANSRLYVNEYFLSKGIKLN
                     PDIELGSHELLLEFAYINLGVSCVIEEFSIDYLENEKLFKLDIKEPIPKRNIGYCHLK
                     DISLSLATKEFLSMISNNI"
     gene            19449..20648
                     /locus_tag="KNP36_000964"
     CDS             19449..20648
                     /locus_tag="KNP36_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003493023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coenzyme F420-0:L-glutamate ligase"
                     /protein_id="HBF0872853.1"
                     /translation="MDRLVGTVSRGVRAPIIRQGDDLVKIVVDSVLNASKSENFEVRD
                     KDVIAVTEAVVARAQGNYAHVDNIAKDVKDKFGDDTVGVIFPILSRNRFAICLKGIAK
                     GCRKVVLMLSYPSDEVGNHLISIDELDDKGINPWSDVLTEEKYRELFGYNKHTFTGVD
                     YVDYYKNLIKDCGAEVEIVFANNPKTILNYTTSILTCDIHTRQRTKRILRQNGAKKVY
                     SLDDIMTASVDGSGYNDQYGLLGSNKATEETVKLFPINCDEVVNKIQGNIKEITGKDV
                     EVMVYGDGAFKDPVGKIWELADPVVSPAYTKGLEGTPNEVKLKYLADNDFADLSGDEL
                     KEAISKYIVEKDNKSDDLTGNMVSQGTTPRRLTDLIGSLADLTSGSGDKGTPIIYIQG
                     YFDNYTK"
     gene            complement(20842..23397)
                     /locus_tag="KNP36_000965"
     CDS             complement(20842..23397)
                     /locus_tag="KNP36_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0872854.1"
                     /translation="MMSLVKFSIQYIKHYKKQSISIVLSIVLSVALLTGIGSLVHSAD
                     KSRIEKIREDSGDYHYFYKVDKEQLNKIKKNKKSKEYTVDRLGVTKPKNQIDEPFIIE
                     FLNADSSYLDMTGRKLLKGTLPSKDGEIVLDTYSLNNLNVNKEIGTEINLDGKIYKLC
                     GILSSLSNPETALEGFVNDYFQPKEKDSYIVYVKYDENKNIKKQNYKFMKKFNISKEK
                     TYINWPLSVEFGVKPPKNIEKYNIFEFLKNLELNTNAIILLVGVFGAAAVYSIFHVSI
                     LQRISQYGVLEVLGANNKQLLFLLFLELFLLFIVGFPIGCFLGIEVASTIYEQFPHIF
                     LSSDIVPGAFFISEKSIYLGFLFILLLLILIAVRVVHQLNKYSSIESMKNFKITNKKK
                     RILESVKHSNMTKVLSHKYMTQKKGMFIGILFSLSLGGIIFLCSSYSIQLTKNNNELT
                     MKADDGLNSDYQITMQTTDFDVGIPKDKISRLNNVEGISKVYPVRYLFGAMQIKEEQL
                     FWKNFFKPLEKDYRIKTFFDGICTKQNEGGYLLKTNIYGYNNGMLEGLNSYIIDGEIN
                     THDMVKNNKVIVRLPMDGTGMYDAVDINPGDTIKVKVPKTMKPTDEIVKFKEENKNDY
                     TTKEFVVAATVKRVMANNIYFIGDYGMDIVMTNGQMKNNFDIENYNSVSIKKTEDSNS
                     EELSENIKSVVSDVKRCIVTDYTIAIEKNNTYLNQKLLFIYGIVFVLLAISLFHIINT
                     VSYLIFSRRHEFGILRAMGITDNKFLLMMIREGFLYGFYASIIMVIGSVIGQFMIYFM
                     VKRVYLYINPILKINTPLYIGMIILNITISIVAVIIPVRQILKSDIISEINKN"
     gene            complement(23394..24080)
                     /locus_tag="KNP36_000966"
     CDS             complement(23394..24080)
                     /locus_tag="KNP36_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872855.1"
                     /translation="MSILVTNNLVKHYGKGETKVKALNGVSIEIERDTFTAIVGTSGS
                     GKSTLLNIIGGLDNPTSGDVIIKGKNISKIGKKDLTVFRRRNIGFIFQNYSLMPVLNT
                     YDNIALPVTLDKGNHIDHEYIEMLMKTLGIWDKRLKFPSELSGGQQQRVAIARALANK
                     PALILADEPTGNLDSKTTMEVVCLLKESSAKFHQTILMVTHNENIAQVCDSIIHIEDG
                     VVVNTGGEVL"
     gene            complement(24157..25065)
                     /locus_tag="KNP36_000967"
     CDS             complement(24157..25065)
                     /locus_tag="KNP36_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872856.1"
                     /translation="MFILAFIICTVVIFIVSTKINRKRYDELNLMLNQILEGKEVTYP
                     DTKDTRASKISHQVKKIKDMIEIEVEQSKSEKEAIKGLISNMSHQLKTPLSNITIYCE
                     LLENINISTLQKKEFLQKMKNETFKIDWLLQSLFKMTKLEDGVIEFEVEELLIKDTLI
                     QSISTIFNKAEAKNIRINLEPFSDIKLVHNKKWTIEAIVNVLENAIKYSPSDSTITIS
                     VIKMELYTKITIKDEGIGIDSRELNDIFKRFYRSKNVENQNGTGIGLYLTRLILEKEN
                     GNIIVESKLGSGCCFSIFLQNCKSLN"
     gene            complement(25067..25738)
                     /locus_tag="KNP36_000968"
     CDS             complement(25067..25738)
                     /locus_tag="KNP36_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872857.1"
                     /translation="MNLLIIEDDINLNEGLFYAFENDGFNVFKAYTKQEGLNIFNSKN
                     IDFIILDCNLPDGDGFDVCQIIREKSDIPIIMLTARDSEIDEVKGLEIGLDDYITKPF
                     SLSVLKARVKVAIRKKSNNKVIYSNGIKLDQKLLKVYKNKECLELSSVEYKLLSYLIE
                     NKGQILLKEQILHHIWDSEENYVDDNIVSVNIRRLRVKVEDDPSNPKYIKTAYGMGYL
                     WNEVE"
     gene            26000..27064
                     /locus_tag="KNP36_000969"
     CDS             26000..27064
                     /locus_tag="KNP36_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S ferredoxin"
                     /protein_id="HBF0872858.1"
                     /translation="MKRVDERNTMFARANYKKDSTAYNDYYKKNPDKKEIDDSIRNRP
                     NLCSEGTMTYNELNSPMASSAFDFLSDIKSLCEGKVSDTKVDVDAKSMTKKIKGLAKQ
                     YGASVVGITKLKDYHIYTNRGRHEENYGEEINLTHKYAIVFGCEMDKEMINRAPMICE
                     VIETSKCYVDASIVGMILSYYIRNLGYDARNHMDANYLVMPVFIARDAGLGDIGRNAI
                     LTNKDYGSRLRLGVVTTDIPLLEDEYVDFGLEDFCKVCKKCSFNCPSHSLSNDIKIGD
                     DGKYNWVIEHETCYIKWRYLGTDCGMCISACPFSQNLETIKNTTSFKGNNELIQKALD
                     EYTSKFGKRIFIPGNPSWLK"
     gene            27222..27908
                     /locus_tag="KNP36_000970"
     CDS             27222..27908
                     /locus_tag="KNP36_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872859.1"
                     /translation="MEKILVVEDDSILNKTLSYNLIEDGYIITSKFTAKSALKSIFEC
                     EFDLIILDINLPDKSGFELCNEIKENYNIPIIFLTANDMECDMIKGYELGALDYITKP
                     FNINIFKQKIKAFLNHLTIKTKQDYYRDGYLEINFSELSANINGNQIIFTPLEYRTLK
                     LLTENPKSILTRKVLLEKLWDIDANFVDEHTLTSVISRIRSKIEKDNLKYIKTVYGMG
                     YMWLGERNEF"
     gene            27898..28929
                     /locus_tag="KNP36_000971"
     CDS             27898..28929
                     /locus_tag="KNP36_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0872860.1"
                     /translation="MNFKKFSFSSIYLIIAVGIIFTAILFSISIYLITDDLKLIALLL
                     IYTIVLCGFIALIIFLLHKKIVIFCSRICHTLDSMMNSEDNIEIELEEETILSRINHR
                     LIRMYEVIQENRNSIAIEKADLQELVSDISHQIKTPIANLKMINTTLLNQTFKTEIQK
                     DFLMDMENQLDKLDFLMQSMVKTSRLETGIITLSKKKNSIYETIATALSGILFDAEKK
                     NIEVTVDCDPNLYIIHDKKWTSEAIFNILDNAVKYTSSNGKIRVATECWVMYTKIDII
                     DNGKGISESRQAEIFKRFYREEDVHDIEGIGIGLYLSRKIISLQGGYIKVTSDIGKGS
                     TFSIFLPNK"
     gene            29011..29676
                     /locus_tag="KNP36_000972"
     CDS             29011..29676
                     /locus_tag="KNP36_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872861.1"
                     /translation="MSILQVINLKKYYGQSSNITKALDGVTLSIEKGEFISIVGTSGS
                     GKSTLLNMMGGLDNPTSGKVIIKGKELSTMSDEQLTIFRRRNIGFIFQNYNLVPLLNV
                     YENIILPIGLDGETIDKDFINEIINMLSLEEKLYDIPSNLSGGQQQRVAIARALVTKP
                     AIILADEPTGNLDSRTSSDVLSLLKVTSKKFNQTIVMITHNNEIAQLTDRIIRIEDGK
                     IVN"
     gene            29689..32106
                     /locus_tag="KNP36_000973"
     CDS             29689..32106
                     /locus_tag="KNP36_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872862.1"
                     /translation="MFRNNNRTFIRKIALNDLKINKLKTYLSGIIIMISTCLLLTVTL
                     VSYNASVDLVNASPYHAIYKSVDEKAKNILYKDKNFSGVGTYKLIGSNKKTDCIMSIV
                     YADDTAIKLMNFQPLKGKLPTNKNEIAISEKYLQEFGLDKDIGDSIKLNYYDDITNKE
                     VQCDFIIVGFLENYYQDNAKQYYTVVSNDYFKNIASTPLQNKSNTFDESRPDTVDVLV
                     KLSEENTEKDSASIKTQLNKIGLSLGIKKYNIYLNDNYIESNLIDGEQIITVLVVGIV
                     VLFSSVFVIYSIFYISVVNSVQMYAKLKSLGMTSFQLKKIISLQGNILSIIFIPLGVI
                     ASCIIAYIIQPLAWQMIADLFIILILSLVMFLTVRISLFKPARIISKISAIEAMQYTE
                     TKFRKKAKNFSYINIKNLALKNIESNRKKNLIALISLSISGVLFISIANLANSIDFKK
                     QLSQQFVYNEDYIISIKSDNLYEHITEIQQNNPLTDSLKNEIKSIHGVKKLIESKSIK
                     SNIIEPYIKDRDEKQFITLIKGITPELSKSLEEYIVSGKIDYTHLDSDSLIINKYRTK
                     YYGLNLKVGDTVTFNIFSGNDIIKKKMKIIGIIDNSNTGGMFFASDKTLESLTPYNTN
                     LDFSILIDKKHSKEVEEKLLSIIQKNSNLMLYSYEDDYRMITRAFQYIIIASYIFVGL
                     ISCFGILNMTNTLINSVLIRKKEFALLQAVGMTRKQLRNMLYREGLNISIKAICTSSI
                     LGYFGSNLLCTFIKDVIRLDFINFKFSIFTILIFSFVLIGIQVLVTELLVRNIEKKSL
                     TERLRSQ"
     gene            complement(32287..33078)
                     /locus_tag="KNP36_000974"
     CDS             complement(32287..33078)
                     /locus_tag="KNP36_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBF0872863.1"
                     /translation="METKQYLIDFYNTYDEDSRLALKHGMVEFLTTMHYIDKYIKSGD
                     CVLEIGAATGRYSHTLARQGYDVDAVELVEHNIEVFHKNTQSNENISITQGNAMDLSV
                     FPDNKYDITLLLGPLYHLYNKEDKQQALHEAIRVTKPGGVVFAAYVISDGCLIDEGFH
                     RGNINVSEYIEKGLIDPQTFAAKSEPKDLFELVRKENIDDLMSAFNVTRLHYVASDGL
                     ALYMREAVDSMDDDAFALYLKYHLATCEREDLVGVTSHAIDIFRK"
     gene            complement(33111..33698)
                     /locus_tag="KNP36_000975"
     CDS             complement(33111..33698)
                     /locus_tag="KNP36_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0872864.1"
                     /translation="MPPKVKITKEMILNTVLDITREVGFEAVNARSIASKLQCSTRPI
                     FTCYENMNELKNEFLAFAYEYYNQYVVNYRNSKSVSPYLLLPLSYIEFAQEETYLFKL
                     LFINDLDLMMKEANDFYKEIDNEKKARLFSESIGIDLECAKVIFLDLFLYTHGIAVLT
                     ATKKLTLDRYSAEKMLKNILTAFIRQEKSDWNLSI"
     gene            complement(33875..35266)
                     /locus_tag="KNP36_000976"
     CDS             complement(33875..35266)
                     /locus_tag="KNP36_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate/H(+) symporter BenE family transporter"
                     /protein_id="HBF0872865.1"
                     /translation="MERLARREQPHIKFGMFKIRIPFIHYRFEKPEAIQGIISSMTSL
                     GTIGLSTQILGLPYEVAWSMAIINSILYCLHVFMGDPVVPGWITASITLTTAYLLKFS
                     MGIERIQALTALQIDLGIIFILMGITGVAGKLVSKIPNSIKGGILMGVGISTIISEFN
                     PKGRFDSYPISITVGILVACFVMFSERFDTLKVKNKFLFHLGEYGVVSAILVSLIVGI
                     FSKEIEIPRFSFDNLVYIVDFKNLINTVSPFGIGFPSVMLFIQGIPMAFMIYIIAFGD
                     FITGENLVLSESENRKDEYIDFNSNRSNVISGIRNIFMAIFSPYIPMCGPLAATLTGS
                     VAQRYKVGKEAMQSVFSGMGTLVWVSAIFICFYPIAQIATPLIPLALSVTLLVQGYLC
                     TKLSMELCNTGVEKGLIGLMGGVIAAKGGTWGLAVGFILYFILIDSKKRKEKDINSIE
                     DCVYEILDKKKSI"
     gene            complement(35450..36754)
                     /locus_tag="KNP36_000977"
     CDS             complement(35450..36754)
                     /locus_tag="KNP36_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA thioesterase/BAAT N-terminal
                     domain-containing protein"
                     /protein_id="HBF0872866.1"
                     /translation="MKVNVYNVESFVDERLKIMVSDLIPNTKLKISVKMEFPWCKGEE
                     FSSYGVFCSNEKGEVDLDLVEPIEGTYKADNCMGLIYSLEKSKTEGKNFAENISIDKP
                     IIMNMIFETSIERKEVELKRIFKSEDITTKYISDEFIGKLFYKQNSNNKTILMLGGSD
                     GNLDALDLLAAPLASRGFNVLTVAYFALEGLPDKLEEVPLEYFEKVFEWISENEITST
                     KEIFVHGTSKGGELAFLLASRYEQIKKVVVSQPHIYCFQALNGLMSGNDTSSWSYKGE
                     PFPYIKVDNDIFFEEQKKNISKGIPFGFNSTYKKSLKRAENRKEARIKIENSKADILM
                     IAGKEDNIWNSYEACLKALEIFEENNYPYNVELLTYNNMGHPLPIPYIMPLKETLCMS
                     MSGGIFSSGGTVEGNSKGQFESWNRTIEFYKKPLSSDLNNYY"
     gene            complement(37113..37988)
                     /locus_tag="KNP36_000978"
     CDS             complement(37113..37988)
                     /locus_tag="KNP36_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="kinase"
                     /protein_id="HBF0872867.1"
                     /translation="MITFDVNGAIIRFDDTKNNYNKIRKIFKLYALEISKNFERDCLN
                     SFQNLKQISDRGLSLGEKYIEESFKKGIETIVSFGIITIDINTFKSVYCEKYLDFKRL
                     FNNLNKTFIIPNKNKKNGHASFLEIESTIKKMSNYLYNDCFKIHYAVVDALIENRITA
                     VHSYIDEESIKKSNALFNNYKDGFIGKADECKVVKQIITLNPYREDVYEFLVKEDGDF
                     SKEIERLTEFLGYDIREYKASLMDIYINELMESDENDVENAKEKIEKYARYIGCSDEN
                     LYVARVNAIYTFANA"
     gene            complement(38192..38878)
                     /locus_tag="KNP36_000979"
     CDS             complement(38192..38878)
                     /locus_tag="KNP36_000979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF554 domain-containing protein"
                     /protein_id="HBF0872868.1"
                     /translation="MFGVIANSLAIAGGCIVGLIIKGGLPQRVSDTIMNGIALCVLYI
                     GISGALEGKNTLVTIISVAVGALIGELIDIDKWVNKLGAFLQSKFSKGNKKDSIAEGF
                     ISSSLLFCIGAMAVVGSLESGLTGSHDTLFVKSVIDGIASIIFTASLGIGVMFSAISV
                     FLYEGIICVGASFLNGFLSDPVVTEMTAAGSLLIIGLGLNVLKLTNIKVANLLPAIFI
                     PILFGVFGII"
     gene            complement(38927..39460)
                     /locus_tag="KNP36_000980"
     CDS             complement(38927..39460)
                     /locus_tag="KNP36_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolyl-tRNA synthetase associated
                     domain-containing protein"
                     /protein_id="HBF0872869.1"
                     /translation="MSDLNNKKEQDENESSMNETKIYDILDKLNVEYDVVEHEAVYTA
                     EQLVILDGITKGCQCKNLFLRNAKGNKYYLIVVKGEKQVDLNSLKDKIGSSRLSFASP
                     ERLYNVLKLLPGSVNPFSLINDTERKVELYIDKDVIKEDYLNFHPNINTKTVNISRKG
                     FEEFLEYLKYPIQSIDV"
     gene            complement(39504..40136)
                     /locus_tag="KNP36_000981"
     CDS             complement(39504..40136)
                     /locus_tag="KNP36_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclase family protein"
                     /protein_id="HBF0872870.1"
                     /translation="MKVFDLTHVTHNDMPVYAEPNRPDIKKVAIIEENGYQETLISVF
                     SHNGTHMDSPRHMYTKGETLDKLDIENFVGKAYVLELEKGNENIELEYLKKYEDEIKN
                     SDFIIFKSGWSKFWDKKQYYVGYPTLTKEAANYIANTNIKGIGIDMLSVDRYDTSVFE
                     VHHILFEKGKIIIENLTNLENVPEKFLFIAAPFKYNDADGAPVRAIAIVE"
     gene            complement(40226..41305)
                     /locus_tag="KNP36_000982"
     CDS             complement(40226..41305)
                     /locus_tag="KNP36_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HBF0872871.1"
                     /translation="MKIAIFLGAGASAAENLPIQNELFSEYFKKLNPTNYNTKMNREL
                     YIFFKQMFNIDIVKDNIDNANFPTFEEVLGLLDLAEQRKEAFRNFGLENLNNRSDSIR
                     FLRQYLILLMAEAIHNTPRTDNKYHKLLVENLLENDLLLDTTFISANYDIHIDNTVTG
                     LRDKNDLPIMLDYGVEFTNFKEELNWRKPKEPLIKLYKIHGSLNWLYCPICNSVTLTP
                     HEGGVMKLIENSSETKCLECGELTEPIIVPPTYFKNMSNIFLSDVWNETEKTLRDTDL
                     LIFCGYSFPEADMHIKYMLKRVQTNRKKPPLKIMVFNNHSQKQRITLKKEEGRYKRFL
                     GEDVIFTDNSFQDFSVNPLRFIKNI"
     gene            complement(41438..42784)
                     /gene="pepV"
                     /locus_tag="KNP36_000983"
     CDS             complement(41438..42784)
                     /gene="pepV"
                     /locus_tag="KNP36_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HBF0872872.1"
                     /translation="MKEQIKEKVNSLQDEMISSIQESVKIPSVISEATENCPFGENVD
                     KALRGILDLCKSLGFKTVYKDGYYGYAEIGQGEKMIGILGHVDVVPEGDLESWNYPPF
                     EAVLEDGKLYGRGTQDDKGPTISAIYAVKALMDLNVDFNKRIRFIFGADEENLWRCIN
                     KYKENNEEIPNYGFTPDSRFPITNAEKGLLQVHLTCDSKSDIELSVGKALNAVPGKAI
                     YIGKYSDKLKKELNKLNFEYTVEGNKICIIGKSVHSAASDTGINAVARLCIALNNIGI
                     DSNIIKFLAEVIGEDANGNNIIPNCKDDVSGKLTVNIGRVTIDNEKEFAGIDVRIPVT
                     YKKDDFVKELKKMTDKYNLNYEEYDFLDSIYVPEDTLLVKTLRKVYEEETGLDGTPLS
                     SGGATYARALDNCVAFGAIFPGKPETEHQANEYLIVEDIIKATQIYALSIYELLKI"
     gene            complement(42853..44133)
                     /locus_tag="KNP36_000984"
     CDS             complement(42853..44133)
                     /locus_tag="KNP36_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine gamma-lyase family protein"
                     /protein_id="HBF0872873.1"
                     /translation="MLNETKELLKDYYGIDDDTFKLSQEIMEEIKDKFEEIKEIREYN
                     QYKVLKAMQESKLSDMHFNWTTGYGYNDIGREKIEEIYSKVFNTEDALVRPIIVNGTH
                     ALTLCIQGIVRPGDEILSVTGRPYDTLEGVIGIREEKGSLKEYGVTYDDVDFLEDGNL
                     DLEGIKNKINDRTKLVMIQRSKGYSWRKSLSISDIKEAIEVIKSVKPEAIVMVDNCYG
                     EFLDTKEPTDVGADVMAGSLIKNPGGGLALTGGYIAGRKDLIELISYRMTSPGIGKEC
                     GLTFGTTRNVLQGFFLAPYIVSQAVMGAIFCSRAFEKLGYDVLPKYDDLRSDIIQCIR
                     LNNADEVISFCEGIQEAAPVDSYVKPVPWDMPGYESEVIMAAGAFIQGSSIELSADAP
                     IRPPYNVYFQGGLTFDHSKMGTLKAIEFIKKLKK"
     gene            complement(44260..44520)
                     /gene="hfq"
                     /locus_tag="KNP36_000985"
     CDS             complement(44260..44520)
                     /gene="hfq"
                     /locus_tag="KNP36_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA chaperone Hfq"
                     /protein_id="HBF0872874.1"
                     /translation="MKNTVLNLQDLFLNNARKERIPVTIYLVNGVQVKGLVKGFDSYI
                     ILIEGDNRQQNMIYKHAVSTIQPGKYINLTNQNQNNNNNNNR"
     gene            complement(44634..45569)
                     /gene="miaA"
                     /locus_tag="KNP36_000986"
     CDS             complement(44634..45569)
                     /gene="miaA"
                     /locus_tag="KNP36_000986"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HBF0872875.1"
                     /translation="MKKIPLIILTGPTAVGKTDLSIKLAKDMNAEIISADSMQIYEYM
                     DIGSAKVTEEEMQGVKHYLIDEVKPDYPFSVSEFQQRAKKYIHEINKKEKCVLVTGGT
                     GLYLNSLIYNMDFAQSDANNELREELQKQLAEKGIDYMHNKLKELDEESANRIHKNNT
                     KRVIRALEVCLSGKKMNDFSSDLKFNEEYQPIIIVLNRDREHLYQRINMRVDIMLKNG
                     LVEEVKKLLSMGFKKDMISMQGIGYKEILKYLDGEYTYEEAIEIIKRDSRRYAKRQIT
                     WFKRYKTAKWFDLDQYENIDELKNEIILYIKDSIK"
     gene            complement(45607..47574)
                     /gene="mutL"
                     /locus_tag="KNP36_000987"
     CDS             complement(45607..47574)
                     /gene="mutL"
                     /locus_tag="KNP36_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HBF0872876.1"
                     /translation="MKNIINILDDLTINKIAAGEVVERPSSVVKELIENSIDAGANKI
                     SIDIIDGGKSLIKITDNGIGIPSSEVEKSFLRHATSKIKKIDDLYDLYSLGFRGEALA
                     SISAVSKLEMTTKTKDEIIGTKIYVEGGKIISKEPIGSTNGTTIIIKDIFFNTPARQK
                     FLKSTHAETINISDLINKLAIGNPNIQFKYTNNNKQMLNTPGDGKLVNTIRSIYGKEI
                     TENIIDVEFKCNHFKMNGYIGNNNIYRSNKNLQHIYINKRFVKSKIIIDAITESYKSI
                     IPIGKHAVCFLNIEVDPSCIDVNIHPNKLEIKFEKEQEVYIELRDFLKVKLIHSNLIG
                     KYATYSDKKTQPRIAINSREKSTDYKLRNNDLLESTPKNSNITKGKDEVIEVVTLSSE
                     KPINEFQSVSEVLNASVEDDVKNINYLSEDSANDNIQEEFQVDGIKNEGNYYLGDSIK
                     DSEEEYLCSSKRKFSLYGYSVIGVVFNTYIILSKDDSMYLLDQHAAHERILYERYMEK
                     FYRQDINMQILLDPVVIEVSNVDMLQIENNLELFMKFGFELEIFGNNHIMVRCVPTIF
                     GVPETEKFILQIIDNIEEITSNYDLKGERFASMACRSAIKANDKIYDIEIKSLLEQLE
                     KCENPFTCPHGRPIMVEISKTEIEKMFKRIM"
     gene            complement(47585..50428)
                     /gene="mutS"
                     /locus_tag="KNP36_000988"
     CDS             complement(47585..50428)
                     /gene="mutS"
                     /locus_tag="KNP36_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HBF0872877.1"
                     /translation="MQIDMNKLTPMMKQYLEVKNRYKDCILFFRLGDFYEMFFEDALV
                     ASKALEIALTGKACGLEERAPMCGVPFHSANSYISKLVENGYKVAIGEQMEDPSTAKG
                     IVRREVIRVITPGTVLDGNLLENKKNNYLLSLYKDGTNIGLTYVDISTGETNATCLNE
                     DKVIEEIAKIHPTEIIINDLDFIENLRDIATVSNIYINESFSDNYLDINILKEYFPDV
                     YLQKLKFDDKGLIKSSLSILLNYIYNTQKQITSNINNINIYNSSEYMVLDMFTRTNLE
                     LTQTIRGNKKKGSLLHVLDKTSTAMGGRLLRKYVEEPLINKSKIENRLDVIEEIKDDF
                     ILREDLNDILKNIYDIERICGKIAFERVTPKELIHLKNSIEKLPNLKDTINLSNAKIL
                     KEYVSEMDKLDDIYNLIDEAILEEPTITIKDGNIIKSDFSDELKELREISKNGAFLVK
                     EIENREREKTGVKSLKIGFNKVFGYYIEITKANFKQAKLDETYIRKQTLSNAERYITP
                     ELKEIEEKILHAEEKIKSLEYEIFVEIRDTIYKNIDRIQKVAKTIANIDVFVSLATVA
                     HINNYVKPAINENNKLDIRNGRHPVVENIVGEENFVPNDTYLNRGENIINIITGPNMS
                     GKSTYMRQTAIIALMAHIGSFVPAESADIPILDRIFTRVGASDDLSQGQSTFMVEMNE
                     VSLILKNATERSLVILDEIGRGTSTYDGISLAWSIVEYIQKNIRCKTLFATHYHELTD
                     LEEEFKEVKNYSIAVKEDGEGIIFLRKIIPQGADKSYGIYVAKLAKLPDEVIERAKYI
                     LKDLEKNHVYNSVAINGDKENNNIINSNLDEELVKVNQSNFKNKYESLKIEHELIVKD
                     YKHIKKDYDKLNSKFKALNDEVALIKQNDDKEKINQVDSVKEVALTQISFDSVNRDIL
                     SEEILNLDILNMTPLDAINSLYNLQRKAKEIKS"
     gene            complement(50588..51322)
                     /locus_tag="KNP36_000989"
     CDS             complement(50588..51322)
                     /locus_tag="KNP36_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872878.1"
                     /translation="MLTQMNFYHNKKVKVSIENVSKTYKDIEVLKDISIDVYEGEFVS
                     ILGPSGCGKSTIFNIITKLTDYDSGKVNINGKYSYMYQKDLLLPYKTIIDNVSLPLIL
                     KKEKKSKARSMVKPYFEVFGLSGYEDKYPSELSGGMRQRANFLRTFINSNDIMLLDEP
                     FGALDSLTKTSMQKWLLDVKKKVNSTILLITHDIDEAIMLSNRIYVISKKPSIVKKEF
                     VIDSRKLNEDNLENIIKLKKEIISLL"
     gene            complement(51291..52304)
                     /locus_tag="KNP36_000990"
     CDS             complement(51291..52304)
                     /locus_tag="KNP36_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0872879.1"
                     /translation="MNFKKLGILGLVSVFTLATITGCSSNNNKDKNNDKDTSSKKVTM
                     VLDWTPNTNHTGLFVALDKGYYKEEGLDVEIVQPPESGAETLVATGKADFGISYQEQV
                     TYAKTSEDPLPIKAVATVIQHNTSGFASPKEKNITTAKDFEGKTYGGWGSPSEEAVFK
                     AVMKKNGADFNKLKIVNTGQDDFFAAMKTVDFAWIFEGWDAVKADLIGYDLNFIPVKD
                     LDERLDYYTPLIISNETVLKDNPELAKKFLKATTKGYEYAIKNPEESAKILVKHAPEV
                     DEKLALKSQEYLASKYKDDAPRWGEMKDSVWNNYTSFLKEYKLIDKDMKASDAYTNEF
                     LPQ"
     gene            complement(52326..53096)
                     /locus_tag="KNP36_000991"
     CDS             complement(52326..53096)
                     /locus_tag="KNP36_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872880.1"
                     /translation="MKNLEIIDKVKDSIYPIATFLFILILWQSMVGVLEVPQYILPTP
                     VDIINVFFKDYQNLSMHAVVTIGEAILGFIVAIIISLVIGILMDFVSIIKKCLYPIML
                     VTQMIPTIIIAPLFMIWFGFGTMPKVLMVMLTCFFPILISFVDGIENIDKDYLNLFKT
                     MDSNKVNTFIHLKFPMAMDKFFSGLKISATYAVMAATVAEWLGGTKGLGVYMLRSKSA
                     YALDKVFASTILVVIFSLMFVGIVQAVKKVVIRHRLID"
     gene            complement(53071..53361)
                     /locus_tag="KNP36_000992"
     CDS             complement(53071..53361)
                     /locus_tag="KNP36_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MTH1187 family thiamine-binding protein"
                     /protein_id="HBF0872881.1"
                     /translation="MVIADIAVMPLRPYKGEEEMYKVVDACIAEIEKSGLKCEIGAMS
                     TTVEGDFDEVFELLKKVHKIPFNLGCERVITVARVDEKAGGLTIDEKLRNHR"
     regulatory      complement(53492..53591)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     regulatory      54211..54300
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            54353..54529
                     /locus_tag="KNP36_000993"
     CDS             54353..54529
                     /locus_tag="KNP36_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872882.1"
                     /translation="MFMDKMDRCTHILTAYICSSRDYCNFIDTQLNDFILEYGENVVE
                     SCLHQVMVLVSRYN"
     gene            complement(54644..55000)
                     /locus_tag="KNP36_000994"
     CDS             complement(54644..55000)
                     /locus_tag="KNP36_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872883.1"
                     /translation="MDIDNNFEEFPNIEERQKDFNCSIGFTMTVIGSKWRAIILWHIL
                     KQEPIRYSQLKKEVVHISHKILSQELKYLERDGLIKRISYPTIPPKVEYLSTKRGKSL
                     ESILLELCNWGKQYMR"
     gene            55467..56215
                     /locus_tag="KNP36_000995"
                     /pseudo
     CDS             55467..56215
                     /locus_tag="KNP36_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816229.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis isomerase"
BASE COUNT        19258 a         8859 c         6364 g        21828 t
ORIGIN      
        1 tactagaatc ttttttatat aatattttta tatgtttcta acgaaaccaa atattagtaa
       61 aatatgtatt tatttaacta aagtttttaa atgggctgac taagcttaaa atataggata
      121 ttatgagagt tactattgaa aaaataaacc ctattgccat aaagaaactt ataaatatgt
      181 tatacttaac tattaaactg gatatattca agttatcaaa tccaaataag tatgtaattg
      241 aacttattac aaaaataact ataactataa agctcaggcc atttaagcta ttttttaaat
      301 cagcactact aagtgacata tgtgtagata tagaatacat taaaaacata aatataaaat
      361 acttcaatga atatacacta ggtgttaaca acattattct tataaaattg gaaatatcac
      421 ctaaaataat gtgtataaaa ccatttatat ttaaattatt aatcatgctt acatataact
      481 ttaaatctat attttgagtc actttcatat aactatctgg cagtaatatc ttaaaaatta
      541 aaataatcat tattgttcca cctataatag gtgcaattcc tataaagaaa tttcctatac
      601 tttgataaag attatctttt ttatagctat gacttacata tcctagtata ccatcatttt
      661 tactttctat tggtctgaaa aacttaactg aatttatttt atgcatgaaa attaaacaca
      721 ttatcaaatg actcaattca tgaacaaatg ttcctatagc tccagttaca ataattccag
      781 tttttccaaa agatgaaaat ataaatttat tatttagatt ttctgtaatg ctaaaaatca
      841 atccaaatac aataaatatt cctatgaaac aaaaaatatt tattacactt atttttaaaa
      901 tttcgattat ataaatcata agttaaatcc tcatgtaaaa gtatttaact actctacttc
      961 atatccatta cagcttaaaa ttttacaagc attttctata tccttttctt ttactaagat
     1021 atagtctgta tcataagtag aaattgcaaa tatgcttatt ttgttgtctg ctaacaaact
     1081 acttaactta gataaaattc ctacaagtga aaagtctaaa ggacctagta tcttaagtat
     1141 tctccactcc ttttctgact taacatcaga aggaatatta ttatttaaac atacaacact
     1201 taattcatca tcagttctag ttatagagta aaacttctct gtatctatcc atgttggtat
     1261 tttactgtca ttatttaatc tacatactgc atactcttct accaataatt ttaatttcat
     1321 aatgtatatt tcctccaatc ttatttgttt acttaagatt atacattaaa agttacataa
     1381 aataaaacat ataaagtaaa aaaggttcac tatagtgtcc tatttctata gccaaccttt
     1441 aaaacttaat taaattctaa taaagagata tattatctag gttcaattat aagtttaatg
     1501 gctgttttct tatcaccttc gatttctata tcagtaaatg cgggaatgca aactaaatcc
     1561 attccactag gtgcaacaaa acctcttgct attgcaattg attttatcgc ttgatttaga
     1621 gctccagctc ctatagcttg tatttctgca acgcctcgtt ctcttagtac tccagccaag
     1681 gctccagcta cagaattagg attagatttt gatgaaactt ttagtacctc catttcaaca
     1741 tctccttgtt aatttgttaa agtatccatt acctaaagta ctaaatcata attgccattt
     1801 actaattaca atcatcattt aaagtatact tttataaaaa tatacttcta taatcgtttt
     1861 aagaaaacct ttattttttt taaccatttt attatgaaaa aactacaaat ttctttatat
     1921 tctataagca ttttccaata tttctaaatt ttttatatct ttgagctata atttcctctt
     1981 tatccatatc tttgtaatga tttaatcttt ctaaaatgta agcttttatt tcttttgaaa
     2041 cagcttctac atctttttgt gctcctccaa gaggttcttt tataatctta tctattattt
     2101 ttaaatcata taaatcatta cttgtaagct tcataacatc acaagcttct ttagctttag
     2161 atgaatcttt aaatagaata ctagaaagcc cttctggaga aatcacagaa taaactgaat
     2221 gttctaacat acatacatca tttcctactc cgatacctaa agctcctcca ctaccacctt
     2281 caccaattac aaaagtgatt actggaacag aaagtttact catttcaagt aagtttcttg
     2341 caatagcttc tccttgtcct ctttcttctg cttctagacc acaaaaagct cctgatgtat
     2401 caataaacgt tattataggt ctattaaatt tttcagcttg tttcataagt cttaatgctt
     2461 ttctgtatcc ttctggatga ggcattccaa aatttctttt tatattttct tttgtatctc
     2521 ttcctttttg gtgtccaact atagtaacat taaactttcc tatctgacca attcctccaa
     2581 ccatagaagg gtcatcttta aaaagcctat ctccatgaag ttctaaaaaa ttagaacaaa
     2641 tatgttctat gtattccaat gtcgtaggtc tctttatatc tctacttaat gttacctttt
     2701 catatgctga tagatgtgaa aaagcatctt ccttaagctt ttccaatttc tcattaagtg
     2761 aatttatttt atcacttaaa tctatattat ttgccttaga aatagttatt aattgtttaa
     2821 tatcattttc taagactttt attttttcac tattattttc aatcaaaaca gttcctcctt
     2881 tatgccctat ttcttgtgca tagcaagaat ttgatataat acttccttca tttttcttct
     2941 atctactatc atgtcaataa aacctttttc aagtaaaaac tcagaagttt gaaatccttc
     3001 aggaagtttt tgatttattg tttgctctat tactcttgga cctgcaaaac ctatcaacgt
     3061 atttggctca gaaattataa tatcaccaag catagcaaaa ctagcagtta ctcctccagt
     3121 agtagggtca gttagaactg atatatatgg caatgatttt tcttcaagct tagaaagtgc
     3181 ttgagaagtc tttgccatct gcataagaga taccatacct tcttgcattc tagctcctcc
     3241 tgaagcagaa caaataatta taggtaaatt attttcagca gcatactcta ttgaataagt
     3301 tattttttcc ccaacaatag aacccatact tcccatcata aaatcaggat tcattacaca
     3361 aataactgtt ttaattccat ttattcttcc ataacctgtg acaacagctt ctgactcttt
     3421 tgttttttcc ttataagagt ctactttttc tttgtattta ggaaaattta gtggattttg
     3481 aaattctaca tcagaattaa actccataaa agttccttta tcaatcaata aatttattct
     3541 ttttcttgct cttaagccat aatgtcttga acattttgga catacaaatg aattttcttc
     3601 tatgtccttt ctaaatacat gactatcaca acctttgcaa taggtccaaa atttatcatc
     3661 tacactattc tttttaaagt tgtcatctaa agaaatcgta acatacttag attcttttga
     3721 tgataaaaat ttttttatca taatctattt actccttata atgtagcaaa ttctttcttc
     3781 ataaagacat cttctataaa tttggtatga tgagtatctt ctctaaactc ctcacttgtt
     3841 acaagtgcct tttgaaattc tacatttgta ttaatacctt ctacaataat ttcgtctaga
     3901 gctctatata ttctacttat acattcttct ctagtttcag cccaacatat taacttacct
     3961 atcatagaat catataaagg tggtatagta tatcctgcat atacaaaagt atcaaatcta
     4021 acaccaaaac ctccaggtaa atttaatgat tctatcttac ctggtgatgg agcaaaattc
     4081 tttgatgaat cttctgcatt tattctacat tcaatagcat gacctctaaa agtaatatct
     4141 tcttgtttaa aaggaatttt atccccatta gctatagata tttgaagttt tataaggtca
     4201 agatttgtta ccatctctgt aactggatgt tcaacttgta ttcttgtatt catctctata
     4261 aaataaaagt ttttatcttt gtcaactata aactcaatag tacctgcacc gatataacct
     4321 actcctttta ctatatctac tgcaatttta tgaagttttt gtctttcttc atctgaaagg
     4381 tatggactta aagattcttc tattactttt tgatttcgcc tttgcataga acaatctcta
     4441 tcacctaaat gtattgcatt tgaatgttta tctccaaata cttgtacttc tatatgtcta
     4501 ggattttcta taaacttttc catatataaa tcactattag aaaatgctgc tagagcttct
     4561 gaacttgcca tatcaaaatt tgaaaaaagt tcttcttctt ttctaacgat tctcatacct
     4621 tttccaccgc ctccacttga ggcttttatc ataacaggat atccaatttc tcttgcaact
     4681 tctaaagctt cttccttagt tttcaaaaca gattctgaac caggaacaac agggatattc
     4741 aattccatca tagtttctct tgctctagat ttatctccca tcaaaatcat ttgttctctt
     4801 gttggaccta taaaaataat attattatct tcacattgct ttgcaaattc aggattctct
     4861 gataaaaatc caaagcctgg atgaatagca tcacacttta atttaagagc aagatagatt
     4921 atattttcta tattattata actcttactt atattatttg gtcctataca aatagattca
     4981 tcagctatat atctatgaaa acaatcttta tctatttcag aatagatagc aacagttttt
     5041 atacctagtt ctttacatgt tctgatgatt ctaactgcta tatcgcctct atttgcaact
     5101 agtatttttt ttatcaactt aaatacctcc tactacaatg gttttatctt aaataaaggt
     5161 tgattatatt ctactagttc ttcattacta actaatactt caattatttc acctttaatt
     5221 tcacttgtta tctcattcat aagcttcatt gcttctaata tacataaagt gtcgccttct
     5281 tcaactacat cgccaacttt aacaaagcta tctgcatctg gacttggaga atcatagaat
     5341 gttcccatca aaggagctac tactactgat agattctcat tagatgtgac aggtgtatcg
     5401 tttacaactg gcttttctaa agaaagatcc actactgatt cttgttgtac acttaaaaca
     5461 ggtgaacttg tagattgagc ttttttagat acttctaatc ttaaatcgct actttcaagt
     5521 tttacatatt ctaagttagt tgagtctatg gcctttaata attccttaat ttcattgatg
     5581 ttcattttgt tacccccttg tattattacc tggtgctaat attatatcac aaaaaacaaa
     5641 tttataaaag aaaaagtgct gactagagaa tcaacacatc aatatatctt ttaattttaa
     5701 attaacaacc agtaacttat atttgtttta attttccatt attaatataa attataagta
     5761 taaaatgaat aaaattcaat attttttgca aaatacaaga gaatacaaat taatacctcg
     5821 ggaattttta agacaaatac caatattatg caatttagac ttcgctttct ttcaaattag
     5881 tatcattttc tttattttta cataggatgt actttaattt agctatcaaa acattgctat
     5941 ataggttaaa agttattaga attgcaggaa ttataaagta aactctagca cctataaaac
     6001 caaaaactac tgtaataagt attaatcttt tatttaaagt aaaaaaaggt atattaaaaa
     6061 tacttttgtc ggatgtttct ggagtataag aatatataac tccaaaaatc aaagtaagca
     6121 tacaaagtgg aagtagtgta taacttgaaa ttattcccaa aaatcctata ctttcaaaat
     6181 atttgctagc actatttgta taaacaaaca tgtatccatt taaatatgcg catatacatg
     6241 atataatgcc aaaagttccc cctaaggatt gagtgtacca attaaaaaat ttagattcca
     6301 tatacctcac ctcctaaaac tgtatatata atgatatgca tttaaatagt aaaatatatc
     6361 tttatatgtt tctgaataaa attttgttaa tttcattaat ttatgtttaa gaaatttgaa
     6421 gtatagtgta gtatatatta atgtagatga agttttatag tacttatttc atagtgctta
     6481 atcaagttat cttattatgg attcaaaagt tgtttgtagg gttttatatt ttgttgagct
     6541 gaaaaattta ttataaatga agggatgttt tcgctttggt agatacatta gaatttggtc
     6601 ttaaaatttt attttttata ttatcaataa tttggatggg taaaataatg attttaagaa
     6661 ctgataagca aatagtaatc aatcctttgc ttattggtat atctgcaatc cttgtgatgt
     6721 tgcatacctc acagagtaac attgaatttt ttggattaga tgtccaatat ataagaatag
     6781 ttttgtatat aatatattca ctgataattt taataggaat atgggctact aacagaagaa
     6841 atggaatttt ttagataatc tatttctata aaatttaaag gttgctagta acaaatcact
     6901 aatattagcg ttctgttact aacaaccttt attttgatta tacacttaaa ttgaaaatag
     6961 aatgattgaa taagttgaca gattatttta cattgacagt aattagaact tcttgagatg
     7021 tatttaaatc atttttgtcg cttagtataa cttttaccac tgctttacct gttttattac
     7081 ctttaattat catatcttca catgaaagta cactcttatc acttacagat acaataaaat
     7141 ttaaatcttt tggaaggtta tcagtaactt cccagtattt ataataacta tcaattttct
     7201 tcgtaattat ttttctcaaa tcaatacttt caccttttgc tatatcaaca ttatgatatt
     7261 tagagtccag tttatactga ttatcttttg tatcaataaa atttaaatcg caatttacat
     7321 ccacaccatt atgagaaaga gaatttacta catcgtcatc aatcaaataa ttattggcaa
     7381 gatttattga atccatatct tttagactta aagcttcctt aggaacctct tttatattat
     7441 tattccaaaa aataaaattg tctacatttt caagatatga tatacctttt aaatttgaaa
     7501 tactctcacc agttgcataa aattctccat ctaaagcctt tatattgctt atagtcatct
     7561 catctggatt tatatatctt tttacaactg ctcttaaatt tgcatcagga aaaatatctt
     7621 taagttgatt ttcgctcaaa accttatcat ttgaatttat tggacttaaa gctgctgcag
     7681 aaataataaa tggtattaaa ttagctaaat tcatagtacc ctcccacata aattttttat
     7741 tataataatt taatttctat gagagggttc tgtttccttg ttatatatac ctactttcgt
     7801 acactttatt aatataaatt aaaataaatt tctactatta aacttataaa catattacta
     7861 gttacgtttt ttagcttcac atctaaatat tcgcatacct tgtgacataa atttgtcttc
     7921 atactctgtt gtaacattat tttcatactc actatttcct aaatcaagag aaatattctt
     7981 taatagccaa ttatttgcag caatttcatt taaactaaac tcgaataatt tttcattatc
     8041 tgttttaaag tgaatttcgc catcatcttc caaaacccta ttgtacattt ctaaaaatcc
     8101 agaatgagtg agtcttcttt tactccatct atttttaggc catgggtcac agaaatttat
     8161 ataaattctc gataattctt tagcttcaaa gtaatccaaa atattgctta catctcccca
     8221 taaaaatagt atattattca aattagaagc atctgctttt tcaacagctt ttaaaagaac
     8281 ttcttcctta agttccatgg caatataatt tatgtcaggg ttctgcttag ctaaagttgt
     8341 tataaactta ccttttccag tcccaaattc aacatgtatt ggattatcat ttctaaactt
     8401 taaattccac ttgcctttta atttgtctat atcgtctctt aaaacatatt ttgtataact
     8461 taaaagcttt tcatctgcac ctttttttcg tcttcttctc acaataattc tccttacata
     8521 taaaaaatta gtaaaataca tttttattat acattatctc accaaaaaat aaaaagaact
     8581 ctcttaaaat agaaatttat ttctataaag agagttctaa acttactaaa aacttaatct
     8641 tagtggcacc ctgaacaacc agagcatcct cctccacctt gatctttcat attttcagga
     8701 ataactctaa atccaaatcc tgtatcttct attattatat ctccatactg actatattca
     8761 tcagagctca ttacaaattg taattctcca acttcataag ttaagtcatc ttcttttttc
     8821 tcatctaaag ctaatccaaa agaaggacct ccacaaccaa cacctgcaaa gtatactctt
     8881 atattattag gtttatcttg attgtctttt aagatacttt ttaaagtatc aatagctgtt
     8941 tctggtaaag taattttcat caaatcattc cctttcaaat attttattaa aacaatatct
     9001 attatatacc catacaaggt acataatcaa ttagtttttg catattttac taaaacttct
     9061 acctaatatt acctaaggct ttaaaatatt ttatataata ttttattacc ttaaataaat
     9121 accctatcat aaacttagta aacaaataaa attattattc taaaaaatat aataatttta
     9181 tttgttgttt taatattata acacatttga taatgtccaa ttcatatatg caaaatttat
     9241 atactttaaa atatctaaga aattattcaa taaaaaaata ctatttttta aaaattatca
     9301 ttattgataa agctctacta tttatatttt ttagtgtatt catgtataat aagtaaaagc
     9361 acaacggtat atactgttgt gcttttttgt aattaataaa caatattttg gtctataaca
     9421 atgaaaaatg gctactttcc ataattgatt tcatctgaca taagcaaaaa gggtgtccag
     9481 ctgggtcaat cataactctc cagtcatcag taaattgctc ctctgcgatt gtagctccac
     9541 aatgaattgc atattgaact gcttcttcta aatccttaac agcgaaatcc atatgagcca
     9601 tttgctgttg agattcaggt ttttctggtt ctattatgcc ccaagccttt gttttttgca
     9661 atataaagaa aaaattatat attttaatat tttatacttg ttgaaattgt gtaataaatt
     9721 caactggata catagtgcgt tttgaaattt cttctaaagc taaaccttgt tttaaaagcc
     9781 tctttatgac gctttccata ctttctgaaa tttctataat atttttatca aaatcataaa
     9841 acctaaaagt tctttgaccc catgggtatt cttttatata atgcaaaaat tcaatatttc
     9901 ctattctatt tatcttactt tcccattgtt tgatgtcatt aacctcaaaa tacaactgaa
     9961 agttatttga ttgttgatat attggtaaat catatccaat tatagcttta taattacttt
    10021 gtaatccaaa tccattttca aatgatacat gttctcctaa atctaatgtg attttttgct
    10081 ccataacatc ttcaaaaaac ttttttgatt tatttatgtc tttgacaatt agcaatactc
    10141 ctccaaattt catcttatca ctatcctttc tttgttataa gtattataac ttaaaatttt
    10201 gcaatttcac tgtaaaaatc agacatatta gctcggtatt tttgaggagt tattccacag
    10261 acaattttaa aatctttaat aaaatgtggt atatcataga atcctaattc attacatata
    10321 gacatccatg aagttttatt attgtttaga agttttatag atttattaat acgtaccaaa
    10381 cgagaaaatg acttcatact caaccctaga tactgattaa agagtctgtt taaatgccta
    10441 gaactataaa atactttttt agaaatttct tgtgaagata tatttccaga gttttgaata
    10501 atcaactgaa ttgccaaaat aaactcatat gagtattcaa ttttaatatt agaaatcaat
    10561 aattcttcca actttaaaat caatttatct atagataaag attcattaaa tattttttta
    10621 atttctaaat ctaatgaagt attaattata gaaaatggaa caactttatc aataagttca
    10681 ctttgctgta tacctataag cgggaaaaaa ccagcaggtt gaaattctat aattagtata
    10741 acatcacatc tattagcaat atttcctact gtttttggtt tagtagttgg accaaataat
    10801 agactatgta accctgtggc atcataaaaa aacaccaaag ttacacttcc atgaggaata
    10861 atcgtgtaat tatcagaaat tattgtttga tttggaaacg atatagtaaa attcgatatc
    10921 caatttctta attgtataca aggcaagaga taaacaaaat tgtcttcaca aactataagt
    10981 gacctatttt tatttataaa atgaatactt tcttttttta acatatatta tatcctgtcc
    11041 tatcgtgaat atttattaaa gtaagaagaa tccatattat ctctatatat cattaactgc
    11101 ttttaataat agagatagta tgaatactca ttagatattt aataaacaaa taaaattaaa
    11161 ataatcaata aaaaatatag tacttttatc tgttatttta atattatagc acatttatag
    11221 tatttaactt atatccactt tacatatgtc taatttatat aattaaaaat gcttatctca
    11281 aatacaataa ttagtcctta tacaattaaa ccatctgaaa ctgtaatagt acgactacta
    11341 cttttggctg cttctggtga gtgagttacc ataattatag tttgtccatt gtctctgttt
    11401 attttattca gtaaatctat tatttctatc cctgttttac tatctaaatt tccagtaggc
    11461 tcatcagcaa atagaatctc tggttttcca attaaagctc gagctatagc aacacgttgt
    11521 tgctgaccac cagataactc tcgtggtgta tgtttacgtc tatcagttaa accaactata
    11581 tctaagattt catctaattg atttttataa tcttttaaat ttttaccatc taataacaaa
    11641 ggaagcatta tattttcctc cacatttaaa tttggtatta agttataaaa ttgaaatacg
    11701 aatcctatat ttctacgacg tattatgctc attttctcat cattaaaatg tgatatatca
    11761 gctccattca tatacacttt tccgctcgtt ggagtatcta aaccacctaa aatatataaa
    11821 agagtacttt taccagaacc agattgaccc atgatagaaa caaattcacc tttcattact
    11881 tgtaaagata cctcttttaa cactcgagtt gttgtatttc caattttata ttctttgata
    11941 atattttttg cttctacagc taaactatta tgtgtaattt tcatattaac ctccataatt
    12001 attcaaactt aatttcttct atcagtttca ttttcttccc ttttataata ggcactatcg
    12061 aacctattaa agttactata attcccaata acccaacaat aataaatgtt ttaaaatcta
    12121 aatctggttt cattgaaatt tttggtcctg caactataaa gatagtttga atctcaagta
    12181 tagatatcac aataccaata acagctccaa gtaaacctga agtaacccct tcaatcaatg
    12241 ttacttttat attttgttta ttacttagtc ctatagattt atacatagct atagaacgtc
    12301 ttttttgaat ataattaatc agtagattat taataatacc tactgtagca agaagaaaaa
    12361 tgaaataggt catcttattc ataggagaca aaaaactact tatagtattt aaagaatcat
    12421 tattaaattc ttcaactgta cgactccaat tatatgtatc tccaaataaa tatcttatct
    12481 gaatcataac agcatctgga ttgactgctg tatatactaa aaaaccataa ttagttttat
    12541 caaaatcatt aactgcataa tgtgatggta taacagcttc tacatcattt gcacgggatt
    12601 taaaactacc tactatttta taagaaaaat catacttatc attagataga gttattgtat
    12661 ctcctataga taagcctact ttttttagag tatcttcatt caaaataaca gaacgtttat
    12721 cattaaaagc ttctattact tgttttttta tctcaaaatt tgtataattg attccaaaca
    12781 tagagttata tagttttata ttatctgtac cctctagtct tgataatgtt acaccattac
    12841 cagaaatctc attattcata acataaagag gtaatatttt tttaattcct tccatatgtc
    12901 taacatcttc aataaactct tcattcatat ttccatctgc aaaaccttgt aattctgcgt
    12961 cacgaaacac atctgttata taagttttga caaagttacc aacaacactt attgcaataa
    13021 ctgcagaaat acttataaat agtaaagtga tattctgtat tatatttttg ttatttttca
    13081 tatttctagc agctaattta ccctcattcc ctaaaatatt tttataaaca aactcaaaaa
    13141 ctatagacat gatatcagta ataagaggaa tcaacacaat agtagctaca attaatccta
    13201 gtaatgaaaa tccaccagct agatacaatg tattttcagg ggatattctt ggaagtaaaa
    13261 tagataaaat aaacattata cttcctataa aaagtataga acgatttgaa acattctttt
    13321 cttctactgt tcctagtaca atatttttta tcggcaaatg gctagctttt ttaacaggta
    13381 tatatgcact aaatgaagaa acgattattg ctactataac agatataatc actccaatgg
    13441 gtgatattac tactggaatt gatattcctt gttcgagaga atttcctaac ccatgaagca
    13501 ttaaatttaa aacaactaca ccaataggaa tagcaattaa tcctcctata cttccgtata
    13561 atatactttc aagcatcaat atacgagtta cagttttttc attggcacca atacttctaa
    13621 atgttccaat aaaaggaaga cgttctaatg taataacctt ataactgctg tatattataa
    13681 atatactaag ggttaatgca aaaaaactta ttaaaaagaa aggcattgtc ttttgtctag
    13741 catctgaaat tatcttagtt tcatttatag tatttgatac catatatttt tcagtagaaa
    13801 gttcttcgga taatttattt actagatttt ctgtaatttc ttcttctgac tctataagaa
    13861 ctcttgtata tccactgcct ttatttataa tttttgatag agtctctttg ggtagcagtg
    13921 catttacacc tcttgtgttc ctcaaaaata ctgtatcata agatgcaata tcactaactt
    13981 gaaaagtata agactttcca taaatctgca aagtaataga atcacctttt tttattttat
    14041 attttgatgt aaagcgattt ggaagaataa ttttatcacc agaaaaatca gtaatactat
    14101 cgccattttc taatcgtggc ttgttgattt tatttagttg acttaagtct gctgatataa
    14161 gactaaattc ttcatagtat ccccctttat tataaatagc agagctttcc aatacaccaa
    14221 cctttgattt tatagtattt aaatcaggta tgtcttctaa attggttaat atatctggat
    14281 ttttactttg gacagatata gtcgctgtac catacatacc ttttgccatt tttctttgtg
    14341 cactttcata agataatcca attgagaatg aaacaaaaag taaaactgtt gataaaacta
    14401 tggacaataa cataactgct gttctaattt ttcgttcttt aatatttgtg aaaatatact
    14461 ttaatataat tttcaaactt acaccttctt cccttatcta agatatttca atctaatatt
    14521 tttatacttt aatctaaatt aaatctctaa tagactcctc catactttta tcattctatt
    14581 tataatattt ttaatcaaat caccccttaa ataaaaaaga ttgataaact actatataaa
    14641 tataataatc tatcaacctt aatatatttt ttatttaacc ttaattaacc ttaattaaat
    14701 aggaaaggtg atataaaatg agctacctaa tccaggtata ctttcaacag atatattccc
    14761 tccatgaact tcaataattt gcttcgttat tgctagtcct aaaccagttc cttctatttt
    14821 ttgttttgta ttgcttcctc tataataacg attaaacaaa tttgatgctt cttctcttga
    14881 catccctttt ccattatcag atataatgat ttcaattctt tcatttaatg ttacatgtac
    14941 acaaacttta gtatttttat ctccatatgt aaaagcattg acaataagat tactaaaagc
    15001 tcgttttaat agtgtacaat caaaatcaaa gttaatatta tctatattac tcttaaattc
    15061 aactatattt gattcatatt ctggataatt taaaatatca atggataatt ctttcaagaa
    15121 tcttactaaa tcataattat ttttatttaa agggattatt ccatttttta attgataggt
    15181 taattttaaa tcgtttataa gtgtatttgt atattctatg ttctttaaca tgattgaagc
    15241 atatttatat actttttcag gtgaataatt agtactacta tctgtaagaa gctctgcata
    15301 cccttttatt ggtgaaagtg gagtttttaa atcatgagtt atatttgaaa tccactcttc
    15361 tctcataata tcagttttat tttgtatctc atcactttta tgaatttctt catttaaaat
    15421 atttaaacta ttatatatat cagcaaaaac acctttaata ttaactggaa gatagcttcg
    15481 ttttgaaata tcactaacag cagatgtaat atttgatatg cactttgtta cccagtaacc
    15541 ataagcaatt ccagaaacca aaattattaa aaatataatc cctatgattg aaaatacaat
    15601 tgacttacca cctataaatt tacctccatc aaaaaacata ttcactttag atatatttaa
    15661 tggaaaatat ataatataaa tatagtcatt tttattattt ttaattgtat taaagtatac
    15721 agttccatta cttgaattat tttggttagc taatgctaat aattcagaat tagaataata
    15781 atctttatgc tcttttggtt ctaaaaaccc ataaactcta tttccactag aatctaaaat
    15841 ttgcaaccac aattgatttt ctcgaagttt ttctaatcca gactgtttta cttgtggctt
    15901 attatctata aatacgattt gttcattaaa gttttctgta aattttttcg gccagtcact
    15961 acgaataaat tccccatttg gtttctgaat agtaataagt gataagaaaa tacctattac
    16021 tgtcaggatt aagcaaataa aaatcatgaa aaaaataatg tatgaatgaa atactgtttt
    16081 ataactaggt ttatgcattt aatcaactct tttcttaaac ttttatttta gtttgattgt
    16141 tgcttatata aaatagacaa taattattga tatgtaaaaa tttatttaaa aatacaacta
    16201 tctacataaa ttatatttat ataattacat gttatcaagc tgtctgttgt atttaataaa
    16261 tcattttgat aacatataaa agtaagataa atttttccat taaatacctt ataattatac
    16321 acaaaatctc tatatacgtt aaacaatata gagaaaattt tcatagaacc atctttatag
    16381 gggatacttt ataaaagaat aaaaaaatta taatatataa aaaacttcat aggagtgtaa
    16441 caacatcagt aaagatatga aaacactata taaaaattca aaaatattaa gaataatgaa
    16501 atacttgaaa ttgcttatat caagaaattt tatataatat aaactggtca aatatgttat
    16561 aatattaaat tgtgacaagt tcatggaggt gtttatatga aaaaacaaaa gtcgccaatt
    16621 ttacttgaaa tgcttggact attttttggt tgtatatcaa tgagtattgg tataaatatg
    16681 tttttaaaac cacatacaat tgctcctgga ggacttagtg gtctatcatt agtactaaac
    16741 aaggttacag gacttccagt atcagctatc atgttaatta taggtgtccc attagtaata
    16801 cttgctttta gaattatggg tacaaaaaat tcattaaaaa ctttatttgg aacagttgta
    16861 ttttcagcta tagttcaatt aacagaccca ttatcaaaac taagatttac taatgactta
    16921 ttattgtctt ctattgcagg aggaatccta gttggtatag gtttaggaat aatgtttaaa
    16981 tcagatgctt ctactggagg aacagactta attgcactca tacttagtaa gaaattccca
    17041 ggaataaaag ctacaaaatt catgtcatgc ctagatggaa tggttgttat atcttctggt
    17101 atagtaaatc gtagtttaga aactgctctt tactctggta tagcactttg tgtattaata
    17161 aaaatagcag atatgataat ggaaggattt gaccattcaa aagcattttt tattatctct
    17221 gatgagcctg aaagtttaag acaagctata actgaagaac ttgatagagg tcttactatt
    17281 cttgatggta aaggtggata cactagagaa aataaagaag ttctattagt cgtagtttct
    17341 aaaaaacaag aactttatct aaagagatta gttaaaagaa ctgaccctac tgcatttgtt
    17401 attgttacag atgtacatga ggttcttgga gaaggattta aaaatttaga gaactaataa
    17461 aaattaatat tttaagtata tatactattt taattaaaat acgatttatt caaaaagagt
    17521 gtctcataaa ctttttagtt catgagacac tcttttttgt ataaaatcaa atgcattttc
    17581 agtattttaa caataaaaac aggattatct atattttgag gcaaccactt tattgaaatt
    17641 ttatttagaa aacaatcatt actaaataac cagcatagat attaaatgat tatatctatt
    17701 gttttttcaa ttcatattga taacaaggaa cattttttac agtatttcca gtatgaattt
    17761 ttttgatata ctttcctgta catttaaatc ctaataaatc taatgatttt gtagaatttt
    17821 ggttttcttc ataggttatt gcaattattt tatttaagtt tagttcccta aatccatact
    17881 gtattactct ttttgttatc tcagtagcaa aatcatgtcc ccaatagctt ggatttatac
    17941 atatacctat ttctgcttct aatgctttag gatttatatt attaaacccc atattcccaa
    18001 taactttatt gtctctttta tatactatag caaagtggcc aattttccct tttttatatg
    18061 gatttagaaa aaatgatttt ataaactttc ttgtatcttc taaagattta tgctcactaa
    18121 atggtaaatg ttttactact attttatttt tataacagtc aaaaaaatct tcaacatcat
    18181 ctaatgatgc aggtcttagt atacaacttc tagtttctaa ggttttcatt tgaggatatt
    18241 cagaatcaga catttctaat ccccctttat acattaatct aaatatactg ttcatattta
    18301 aaatacgata ttaattatat aaatgttctc aaattaacct tatttttatt tttaataaaa
    18361 actaattact atatgaatct ttcaaattta cgaatttatc tctattttta tattaaatta
    18421 cttgtgaaat atgtattcta aattatatat tattagatat catgcttaaa aattctttgg
    18481 ttgctaagga taaagatata tcttttaaat ggcaataacc tatatttctc ttaggtattg
    18541 gctcttttat atctaattta aacaatttct cattttccaa ataatctatg ctaaattctt
    18601 ctataacaca agacactcca agatttatat acgcaaattc taaaagtaat tcatgagaac
    18661 ccaattctat atctgggttt agttttatac cttttgataa aaaatattca tttacataaa
    18721 gtcttgaatt tgctttattt tctagcatta ttaaaggcaa tgtgtttaat tcttccaatg
    18781 atattttcct acctttgtat tctatgtaat catttgcaca tacaaatata tcatgtattt
    18841 caatacactc aacaatattt agtgtatcat cttctattgg catgtttata attgctatat
    18901 ctatattccc atctttgagt aaagatataa gttctctact cgttctattt attgtagata
    18961 catgtatatg tggatacttc ttatgaaaaa tttctaaata ttttaacaag aaaaaacgtg
    19021 cagctgtatc tcctactcct attttcagag aaccgtattc taatttttta aatttattta
    19081 ttctatcttc tcctgatgat attaacttta atgcagtagt gacatgttca cttagaattt
    19141 tcccctctgg agttaatttt actcctttat tgtttctata aaataataaa gtatctaatt
    19201 gttcttctaa ttgctttatt gactggctta cagctggctg tgacataaac aattccttag
    19261 cagcaagaga aaaactctta ttatttacaa ctgcattaaa aaccttataa agttcaagtt
    19321 ttatattcat atataattac tccttatgtc aaatattagt attatttatt ttacttataa
    19381 ttatatttga attataatat acatggtact aatatgacaa tattaattct ttaggaggat
    19441 tttagataat ggatagatta gttggaactg tttcaagagg ggttagagca cctattataa
    19501 gacaaggaga tgacttagtt aaaatagttg ttgattctgt tttaaatgcg tcaaaaagtg
    19561 aaaactttga agttagggac aaagatgtaa ttgccgttac agaagctgtt gtagctagag
    19621 cacagggaaa ttatgctcac gttgacaata ttgcaaaaga tgtaaaagat aaatttggag
    19681 atgatactgt tggagttata ttcccaattt taagtagaaa tcgttttgct atatgtttaa
    19741 aaggaattgc aaaaggatgt agaaaagtcg tattaatgtt aagctaccct tctgatgaag
    19801 ttggaaatca cttaataagt attgatgaac ttgatgataa gggaataaat ccttggtcag
    19861 atgttttaac agaagaaaaa tacagagaac tatttggata taacaagcat acatttactg
    19921 gtgtagatta tgttgattat tataagaatt taatcaagga ttgtggtgca gaggtagaaa
    19981 tagtatttgc aaacaatcca aaaactattc ttaactatac aacaagtatt ttaacttgtg
    20041 atatacatac aagacaaaga acaaagagaa ttttaagaca aaatggagct aaaaaagtat
    20101 attcacttga tgatataatg acagcaagtg tagatggtag tggttacaat gaccagtatg
    20161 gacttttagg ttcaaacaaa gctacagaag aaacagtaaa attattccct ataaattgtg
    20221 atgaagttgt aaacaaaatc caaggtaata taaaagaaat aacagggaaa gatgtagaag
    20281 taatggttta tggagatgga gcttttaaag accctgtagg taaaatatgg gaattagctg
    20341 acccagtagt atctcctgct tatacaaaag ggctagaggg aactccaaac gaagtaaaat
    20401 taaaatactt agcagataat gattttgctg acttatctgg tgatgagtta aaagaagcaa
    20461 tttcaaaata catagttgaa aaagataata aatctgatga tttaacagga aacatggttt
    20521 ctcaaggtac tactccaaga agattaacag accttatagg ttctttagca gatttaacat
    20581 ctggaagtgg agataagggt actcctatta tttacataca aggatatttc gataactata
    20641 caaaatagta tgttttaata agatttaatt tttttggatt atatatatta acatgaaaat
    20701 ttattaaaac ctcttaatag atatgacttt tcaagagtta tatctattaa gaggtttatt
    20761 taatgttcac agataagata tatttaaata atttaaacaa gattgtcaga aagttatata
    20821 atcttaaaaa tttatataac tctaattctt atttatttct gaaataatat cactcttcaa
    20881 aatttgtctt actggaataa ttacagcaac tatactaata gtgatattta aaataatcat
    20941 acctatgtat agaggtgtat ttattttaag aattggattt atatataaat atacacgttt
    21001 taccataaaa taaatcataa attgtccaat aacacttcca attaccatta taatacttgc
    21061 atagaatcca tataaaaaac cttctcttat catcataagt aaaaacttat tatccgtaat
    21121 acccatagct cttaaaattc caaactcatg tcttcttgaa aaaattaagt agcttactgt
    21181 attgattata tggaacaaac ttattgcaag aagtacaaat acaataccat atataaataa
    21241 gagtttttga tttaagtagg tattattttt ttcaatagca atggtataat ctgttacgat
    21301 acatcttttt acatcactta caacactttt tatgttctca gacaattcct cactgttact
    21361 atcttctgtc ttttttatac ttactgaatt ataattttcg atatcaaagt tatttttcat
    21421 ttgcccattc gtcataacta tatccatacc ataatcacca atgaaatata tgttatttgc
    21481 catcacacgt tttacagtag cagcaactac aaattctttt gttgtataat cattcttatt
    21541 ttcttcttta aatttaacaa tttcatctgt tggtttcatt gtctttggca ctttaacttt
    21601 tattgtatct cctggattta tatcaactgc atcatacatc ccagttccat ccataggtag
    21661 tctaactata accttattat ttttaaccat atcatgggta ttaatctccc catctataat
    21721 ataagaattt aatccttcta acataccatt gttataacca taaatatttg tttttaaaag
    21781 atagccacct tcattttgct ttgtacaaat accatcaaaa aaagtcttta tcctgtaatc
    21841 tttttcaaga ggtttaaaga aatttttcca aaatagttgt tcttctttaa tttgcatagc
    21901 tccaaataaa tatcttactg gatagacttt tgatattccc tcaacattgt ttaatcttga
    21961 aattttatct tttggtatac ctacatcaaa atctgttgtt tgcatagtta tttggtagtc
    22021 agaatttaaa ccatcatcag ctttcattgt aagttcatta ttatttttag taagctgtat
    22081 agagtaacta gaacataaaa atataattcc accaagtgat aatgaaaaca aaattccaat
    22141 aaacattccc tttttttgag tcatgtattt atgagataat acttttgtca tgttagagtg
    22201 ttttacactt tctaatattc tctttttctt attagtaatc ttaaagtttt tcatagattc
    22261 tatactagag tatttattca actgatgtac aacacgtaca gcaattaaaa ttaacaacaa
    22321 taagataaat aaaaagccta aataaataga tttttcactt ataaaaaatg ctcctggaac
    22381 aatatcacta ctcaaaaata tatgtggaaa ttgttcatat attgtagacg ccacttcaat
    22441 acctaagaag caacctatag gaaatccaac aataaaaagt aaaaataact ctaaaaatag
    22501 tagaaataaa agttgtttat tattagcgcc taatacttct aaaaccccat attgtgatat
    22561 tctctgaagt attgaaacat ggaaaatact atatactgct gctgcaccaa acactccaac
    22621 aagtaatata attgcatttg tatttagttc taaatttttt aagaactcaa atatattata
    22681 tttttctata ttttttggtg gttttactcc aaattcaact gaaagaggcc agtttatata
    22741 agttttttct tttgatatgt tgaatttttt cataaattta taattttgct ttttaatatt
    22801 tttattttca tcatatttta cataaactat ataagaatcc ttttctttag gctgaaaata
    22861 atcgtttaca aatccctcca gagcagtttc tgggtttgaa agacttgata aaataccaca
    22921 taacttatag attttaccat ctaaattgat ttctgttcca atttctttgt ttacatttaa
    22981 attgtttaga gaatatgtgt caagtactat ctctccatct ttactaggaa gagttccttt
    23041 taataatttt ctacctgtca tgtctaaata tgaagaatca gcatttaaaa attctataat
    23101 aaaaggttca tctatctgat ttttaggttt tgtaacgcca agtctatcta cagtgtattc
    23161 ctttgatttt ttattttttt taattttatt aagttgttcc ttatctactt tatagaaata
    23221 atgataatct ccactatctt cccttatctt ttcaattcta cttttgtctg cactatgaac
    23281 taaagaacca attcccgtca ataatgctac tgatagtact atacttaaaa ctatagatat
    23341 agattgtttt ttataatgct ttatatattg aattgaaaat tttactagag acatcatagt
    23401 acttcaccac cagtattcac cacaactcca tcttcaatat ggataattga gtcgcatact
    23461 tgtgctatat tttcattgtg tgttaccata agtatcgttt gatggaattt tgcactactt
    23521 tcttttaata aacataccac ttccattgta gttttactat cgagatttcc tgttggttca
    23581 tctgctaata taagcgcagg tttatttgcc aaagctctag caattgctac cctctgttgt
    23641 tgaccaccag atagttcgct tggaaatttt aaacgcttat cccaaattcc caatgtcttc
    23701 atcagcattt caatatattc atggtctata tggtttcctt tatctaatgt aacaggaaga
    23761 gctatattat cataagtgtt taatacgggc attaaactgt agttttgaaa tataaatcct
    23821 atatttcttc ttctaaacac tgtcaaatct ttttttccta ttttagatat gttctttcct
    23881 ttaattatta catcacctga ggttggatta tctaatccac ctataatatt taacaatgtg
    23941 ctttttccag aaccagaagt tccaactata gcagtaaatg tatctcgttc aatttctata
    24001 cttactccat ttaaggcttt tactttagtc tcaccttttc catagtgttt tactaaatta
    24061 ttcgtcacta atatactcat ttaatttctc ctttcaatac agatatatgt tctataaaat
    24121 attgtaagtg acgataatta cactcatcct acaaaattag tttaaactct tacaattctg
    24181 taagaagata ctaaaacaac atccacttcc tagtttagat tctactataa tgtttccatt
    24241 ttctttttct aaaattaatc ttgtaagata tagaccaatc cctgtgccat tttggttttc
    24301 aacattttta cttctgtaaa atcttttaaa aatatcattt agttctctac tatcaatacc
    24361 tattccctca tctttaatag taatcttcgt atatagttcc atttttatta cagaaatagt
    24421 aatcgtgcta tctgatggtg agtattttat tgcattttct aaaacattta caattgcttc
    24481 tatggtccac tttttattat gaactaattt tatgtctgaa aatggttcga gatttatcct
    24541 tatattttta gcttctgctt tattaaagat agtactgata ctttgaataa gagtatcttt
    24601 aattagtagt tcttctactt caaattctat aactccatcc tctaatttag tcattttaaa
    24661 taaggattgt aacagccagt caatcttaaa agtttcattt ttcatctttt gtaaaaactc
    24721 cttcttctgt aatgtggaaa tatttatatt ctccagaagt tcacaataaa tggttatatt
    24781 tgaaagtgga gtttttaatt gatgtgacat atttgatatt aaacctttaa tcgcttcttt
    24841 ttctgacttt gactgttcta cctctatttc tatcatatcc ttaatttttt ttacttggtg
    24901 agaaattttt gacgctcttg tatcctttgt atctggataa gtaacttctt taccttccaa
    24961 tatttgattt aacatcaaat ttaattcatc atatcttttt cgatttattt tagtagatac
    25021 tataaatata acaactgtac atattataaa ggctaatata aacatattat tctacctcat
    25081 tccataaata acccattcca taagctgttt ttatatattt tggattagat gggtcatcct
    25141 ctacttttac tctaagtctt cttatattta cagatacaat attatcatca acataatttt
    25201 cttcgctgtc ccaaatatgg tgtaaaattt gttcctttaa taatatttga cctttatttt
    25261 caattagata acttagaagc ttatattcta cagagctaag ttccaaacat tctttatttt
    25321 tatatacttt tagtaacttt tggtccaatt ttattccatt ggaatatatt actttattat
    25381 tcgatttttt tcttattgct actttgactc ttgcctttaa tacagataaa gaaaatggtt
    25441 ttgtaatgta atcatcaagc cctatttcta atccttttac ttcatcaatt tctgagtctc
    25501 ttgcagtaag cattataatt ggtatatctg acttttccct tattatttga catacatcaa
    25561 atccatctcc atctggaaga ttgcagtcta agattataaa atctatattt ttactattaa
    25621 atatatttaa tccttcttgt tttgtataag ccttaaatac attaaatcca tcattctcaa
    25681 atgcataaaa aagaccttca tttaagttta tatcatcttc aataattaat aagttcaatt
    25741 ttactctcct ttagattttt tagataaata attattttct tgcattatca tactaaaaat
    25801 attttaattt tatttatttc actaaaaaga ttgtatttaa atttgttttc aaaataaaaa
    25861 cattataatc aagcatatag ttatatattt cccaatttaa ttacgcttaa attgaaaata
    25921 taactttatt cttatataat taaattatac aacaataaag ttatattttt taaatatatt
    25981 tttactaggg ggaatagaat tgaaaagggt tgatgagaga aatactatgt ttgcaagagc
    26041 aaattacaaa aaagatagta ctgcttataa tgactattat aagaaaaatc ctgacaaaaa
    26101 agaaattgat gatagtataa gaaatagacc aaatttatgt agtgaaggaa caatgactta
    26161 caatgagtta aactctccaa tggcaagtag tgcattcgat tttttatctg atatcaaatc
    26221 tttatgcgaa ggaaaagttt ctgatactaa agtagatgta gatgcaaagt caatgacaaa
    26281 aaaaattaag ggtcttgcaa agcagtatgg agcttctgta gttggtataa ctaaattaaa
    26341 agactatcat atttatacaa ataggggtag acatgaagaa aattacggtg aagaaattaa
    26401 tctaactcat aagtatgcaa ttgtatttgg atgtgagatg gataaagaaa tgataaatag
    26461 agctccaatg atatgtgaag ttatagaaac atcaaagtgc tatgtggatg catctatcgt
    26521 cggcatgatt ttaagttact atataagaaa tttaggatat gatgctagaa atcatatgga
    26581 tgctaattat ttagtaatgc ctgtttttat agctcgtgat gctggtttag gagatatagg
    26641 aagaaatgct atacttacaa ataaagatta tggctctaga cttagattag gtgttgttac
    26701 tacagatatt cctcttttag aagatgaata tgttgatttt ggactagaag atttttgtaa
    26761 ggtctgtaaa aaatgctctt ttaactgccc ttctcattcg ctttctaatg atattaaaat
    26821 tggtgatgat ggaaaatata attgggtaat tgaacatgag acatgctata ttaaatggag
    26881 atatttaggt acagattgtg gtatgtgtat atctgcttgc ccatttagcc aaaatctcga
    26941 aactataaag aatactactt catttaaggg taataatgag cttattcaaa aagctttaga
    27001 tgagtatact tcaaaatttg gtaaaagaat atttatacct ggaaatccat cttggttgaa
    27061 ataattttat ttaataaaga atctgtacta gaatttatca taggacaggt tctttattaa
    27121 atatataaat ttttaaatac tttttctcgt ttataacaat tcagcaatgt ttttagtcta
    27181 taattgacat tataaaatat taaactaaaa ggagtaactg tatggaaaaa atattagtag
    27241 tagaagatga ttctatatta aataaaactc tatcatataa cctaattgaa gatggatata
    27301 taattacttc aaaatttaca gctaaatctg cactaaagtc tatttttgaa tgtgaatttg
    27361 atttaataat tttggatatt aatttaccag ataaaagtgg gtttgaatta tgtaatgaaa
    27421 taaaggaaaa ttacaatata ccaataattt ttttaactgc taatgatatg gaatgtgata
    27481 tgattaaagg ctatgaactt ggagctttgg attatataac aaaaccattt aatatcaata
    27541 tatttaaaca aaaaattaaa gcttttttaa atcatcttac aataaaaaca aaacaagatt
    27601 actataggga tggatatctt gaaattaact tttctgagtt atctgccaat ataaatggaa
    27661 atcaaattat atttacacca ttagaatatc gtactttaaa actgcttact gaaaatccta
    27721 aaagtatttt aacaaggaaa gtacttttag aaaaactctg ggatatagat gctaactttg
    27781 tagatgaaca tactttaaca tctgttataa gtaggattag aagcaaaatt gaaaaagaca
    27841 atcttaagta tatcaaaacg gtatatggta tgggatatat gtggttaggt gaaagaaatg
    27901 aattttaaaa aattttcttt tagttctatt tatttaataa ttgctgttgg tataattttt
    27961 acagctattt tatttagtat ctcaatttat ctaataactg atgatttaaa actaattgct
    28021 ctattattaa tatatacaat agtactttgt ggatttatag cattaataat atttttactt
    28081 cataaaaaaa tagttatatt ttgttctaga atatgtcaca ctttagatag tatgatgaat
    28141 agtgaagata atattgaaat tgaattagaa gaagaaacta ttttatcacg tatcaatcac
    28201 agattaatta gaatgtatga agttattcaa gaaaatcgca atagtattgc tatagagaaa
    28261 gctgatttac aagaactagt ttctgatata tctcatcaaa ttaaaactcc tattgcaaat
    28321 ttaaaaatga ttaatactac tctactaaat caaacattta aaacagaaat tcaaaaggat
    28381 tttttaatgg atatggaaaa ccaattagat aaattagatt ttttaatgca atctatggta
    28441 aaaacctcca gactagagac aggtataatc acactatcta aaaagaaaaa ttcaatttat
    28501 gaaacaattg ctacagcact tagtggaatt ttgtttgatg ctgaaaaaaa gaatattgaa
    28561 gttacagttg attgtgaccc aaatttatat ataattcatg acaagaaatg gacttctgaa
    28621 gctattttta atatattaga taatgctgta aaatacacaa gttctaatgg taagatacgt
    28681 gtagctacag aatgttgggt tatgtataca aaaatagata ttattgataa tggaaaagga
    28741 atatcagaaa gtcgccaagc agaaatcttt aaaagatttt atcgtgaaga agatgtccat
    28801 gacatagaag gtattggaat aggtctctat ctttcaagaa aaattatatc tcttcaaggt
    28861 ggctatatta aagttacatc agatattgga aaagggtcga ctttttctat tttcttacct
    28921 aataaataaa tttttaaata tttcatttgt aatgattctg caacattttg gttttatact
    28981 gtatttacaa gatgttaagg aggtattatt atgagtattt tacaagtaat taatttaaag
    29041 aaatattatg gacaaagttc aaacattaca aaagctcttg atggtgtaac tctatctatt
    29101 gaaaaaggcg aatttatttc tattgtaggt acatctggta gtggcaaatc cacattatta
    29161 aatatgatgg gaggattaga taatcctaca tctggaaagg ttattataaa gggtaaggaa
    29221 ttatctacta tgtctgatga acagcttaca atctttagac gcagaaatat aggttttata
    29281 tttcaaaatt ataatcttgt tcctttactt aatgtatatg aaaatattat cttaccaata
    29341 ggattggatg gagagaccat agataaggat tttataaatg aaattataaa tatgctttct
    29401 cttgaagaaa aattatatga tataccaagt aatctttctg gtggtcaaca gcaacgtgtt
    29461 gctatagcta gagcacttgt aacaaaacca gctattatac tagctgatga accaacaggt
    29521 aaccttgata gtagaactag ttcagatgta ctgagtttac ttaaagtgac aagtaaaaaa
    29581 ttcaaccaaa caattgtaat gattacacac aataatgaaa ttgcacaact aactgataga
    29641 attattcgta ttgaagatgg aaaaattgtt aactaggagg tgtagtatat gtttagaaat
    29701 aataatcgca catttataag aaaaatagct ttaaatgatt taaaaattaa taaacttaaa
    29761 acatatcttt caggtatcat tataatgatt tctacatgtt tattattaac agtgacctta
    29821 gtttcatata atgcctctgt agatttagtt aatgcatctc catatcatgc tatatataaa
    29881 tctgtagatg aaaaagcaaa aaatatacta tataaagata aaaactttag tggcgtagga
    29941 acttacaaat taattggaag taataaaaag acagattgta ttatgtcgat tgtttatgca
    30001 gatgatacag caattaaact tatgaatttt caaccattga aaggcaaact acctacaaat
    30061 aaaaatgaaa ttgctatttc agaaaaatat ttacaggaat ttggtttaga taaagatatt
    30121 ggagatagca ttaaattaaa ttattatgat gatattacga ataaagaagt tcaatgtgat
    30181 tttattattg ttggatttct agaaaattat tatcaagata atgccaagca atactataca
    30241 gtcgtttcaa atgattattt taagaatata gcttctacac ctttacaaaa taaaagtaat
    30301 acttttgacg agtcaagacc tgatactgta gatgtattag ttaaactatc agaagaaaat
    30361 acagagaaag attcagcttc aattaagaca cagttaaata aaattggttt atctttaggt
    30421 attaagaaat ataatatata cttaaatgat aactatattg aatcaaattt aattgatggt
    30481 gagcagatta ttacagtttt agtagttgga atagttgttc ttttttctag cgtttttgtt
    30541 atatatagta ttttttatat ttcagttgtt aattcagttc agatgtatgc taagttgaaa
    30601 tcgttaggta tgacttcttt tcagttaaaa aaaattattt ctctacaagg aaatattttg
    30661 tcaattattt ttattccatt aggggttata gcttcttgta taattgctta cataattcaa
    30721 ccattagcat ggcaaatgat agctgattta tttataattt taattttatc actggtaatg
    30781 tttttaactg ttagaatttc tttatttaaa ccagctagaa ttatttctaa aatatctgct
    30841 attgaagcca tgcaatatac agaaactaaa tttagaaaaa aagcaaaaaa ttttagttat
    30901 ataaatataa aaaatctagc attaaagaat atcgagtcaa atagaaagaa aaatttgatt
    30961 gcattaatat cgctaagcat tagtggagtt ttatttattt caatcgctaa tcttgctaat
    31021 tcaatagatt tcaaaaaaca actatctcaa caatttgtct ataacgaaga ttatataatt
    31081 agcattaaga gtgataactt atatgagcat attacagaaa tccaacaaaa taatccacta
    31141 acagattctc ttaagaatga aattaaatct attcatggag taaaaaaatt aattgaatcc
    31201 aaatcaatta aaagtaatat tatagaacct tacatcaaag atagagacga aaaacaattt
    31261 attactctaa ttaaaggtat tacgcctgaa ctttcaaaat cacttgaaga atatattgtc
    31321 agtggaaaaa tagactatac acatttagat tcagatagtt taattataaa taaatataga
    31381 acaaaatatt atggattaaa tttaaaagtt ggagatacag ttacatttaa tatctttagt
    31441 ggaaatgata ttattaaaaa gaaaatgaaa attataggaa tcattgacaa ttccaataca
    31501 ggaggtatgt tttttgcttc agacaaaact ttagaatctc taacaccata taatacaaat
    31561 ttagattttt ctattttaat agataaaaag cattctaaag aagttgaaga aaagttgtta
    31621 agtataattc agaaaaattc aaatttaatg ctttattcat atgaagatga ttatagaatg
    31681 attactagag catttcaata tataattata gcttcataca tttttgttgg tttaatttct
    31741 tgctttggta tactaaatat gaccaatacc ctaataaaca gcgttttaat tagaaaaaaa
    31801 gagtttgcat tacttcaagc cgttggaatg acaagaaagc aactgcgaaa tatgctttat
    31861 agagaaggtc taaacataag tatcaaagct atatgtactt caagtatact aggttatttt
    31921 ggttcaaatc tactttgcac ttttataaaa gatgtaatta gattagactt tattaatttt
    31981 aaattttcta tatttactat tttaattttt tcattcgtat taattggtat acaagtttta
    32041 gtgactgaat tacttgtaag aaatatagaa aaaaaatcac ttacagaacg cttacgttct
    32101 cagtaagaat gtatataaaa aatagccatt ttttatacaa gttttaacat aattttttaa
    32161 aagctaaaag gatagaaaat tttgacttta cataattttc tatccctata cttgttttta
    32221 ttttatacag atacacttac ttatatctcc gagcaacatc accagagaca taaacaagca
    32281 tattccttat tttctaaata tgtcaattgc atgacttgta acccctacta aatcttcacg
    32341 ttcacaagta gcaaggtgat attttaaata taatgcaaat gcatcatcat ccatagagtc
    32401 tactgcttca cgcatataca aagccaaacc atctgatgcg acataatgca gtctagttac
    32461 attaaatgca gacatcaaat catcaatgtt ttctttacgt acaagctcaa acaaatcctt
    32521 tggttcagac ttagcagcaa atgtctgtgg atcaatcaaa cctttttcaa tatattcaga
    32581 tacattaata tttcctctat ggaacccctc gtcaataaga cagccatcag atataacata
    32641 tgcagcaaaa accacaccac caggttttgt tacacgaatt gcctcatgta aagcttgttg
    32701 tttatcttct ttgttataaa gatgatatag tggtcctaac agtaacgtaa tatcatattt
    32761 attatctggg aaaacagata aatccatagc attaccctga gtaatgctta tattttcatt
    32821 tgattgagta tttttatgga aaacctctat attatgttcg actaattcca ctgcgtcaac
    32881 atcatatccc tgacgtgcca gtgtgtgaga ataacgacca gttgcagcgc caatttcaag
    32941 cacacaatca cctgatttta tgtacttatc aatgtaatgc atagtagtga gaaattccac
    33001 cattccatgt tttaatgcaa gtcgactatc ttcatcataa gtattataaa agtcaattaa
    33061 gtattgtttt gtttccataa tttcacctct tctatattag ttaataaaca tcaaatagac
    33121 aaattccaat ctgatttttc ttgtcttata aaagctgtta atatattttt caacattttt
    33181 tcagcactat atctatctaa tgttaatttt tttgttgctg ttaagacagc tatgccatga
    33241 gtataaagaa ataaatctaa aaatattact tttgcacatt ccaaatctat tccaatgctt
    33301 tccgaaaaaa gtcttgcctt tttttcattg tcaatttctt tataaaaatc attcgcctct
    33361 ttcatcatca aatctaaatc atttataaat aacaacttaa ataaatacgt ttcttcttga
    33421 gcaaattcaa tgtatgaaag cggaagcagt aaataagggc ttacactttt agaattacga
    33481 taattaacaa catactgatt ataatattca tatgcaaaag caagaaattc attttttaat
    33541 tcattcatgt tttcataaca agtaaaaatt ggtcgagtgg aacactgtaa tttacttgca
    33601 atactcctcg catttacagc ttcaaatccc acttctcttg taatatccaa gactgtattc
    33661 aaaatcattt cttttgttat ctttacttta ggtggcatat atgttcacct ctccattaaa
    33721 tttttataaa acacatgtgt tatataacta tagtaacata tcaagaaatt atgtcaagaa
    33781 aaagctttgc atttttttgc aattcctaaa acttataaat aaaacatgag ttgcaattaa
    33841 tctattaata gataacagca actcagattt tcctttaaat actcttcttt ttgtctaata
    33901 tttcatatac acaatcttct attgaattaa tatctttttc ttttcttttt ttagaatcaa
    33961 ttaaaatgaa atacagtata aaacctacag caagtcccca tgttccgcct ttagcagcaa
    34021 ttacacctcc cataagtcca atcaatccct tctcaacacc tgtattacat agctccattg
    34081 atagctttgt acataaatat ccttgaacta aaagtgttac tgacaatgct aatggtataa
    34141 gaggtgtagc aatctgcgca attggataaa aacagataaa aattgctgaa acccatacta
    34201 atgtacccat gccactaaaa acagactgca tggcttcctt tccaaccttg tacctttgag
    34261 caacacttcc tgtaagtgtc gcagctaatg gaccgcacat tggtatatat ggagaaaaga
    34321 ttgccataaa aatatttctt atcccactta taacattaga cctatttgaa ttgaaatcta
    34381 tatattcatc ttttctattt tcactttcag aaagtactaa gttttcacct gttataaaat
    34441 caccaaaggc aattatgtat atcataaaag ccattggtat cccttgtata aataacatta
    34501 cacttggaaa acctattcca aaaggagata ctgtatttat cagattttta aaatctacta
    34561 tgtaaactaa attgtcaaaa ctaaatctag gaatttctat ttctttacta aatataccta
    34621 ctattaaact cactaaaata gctgatacta caccatattc tcctaaatga aataaaaatt
    34681 tattcttaac ttttagagta tcaaatcttt cagaaaacat tacaaaacaa gcaaccaaaa
    34741 ttcctactgt tatagatata ggataagaat caaatctccc tttaggatta aactctgata
    34801 ttatagtcga tataccgaca cccattagta ttccaccttt aatagaattt ggtatcttac
    34861 taactaactt tccagctaca ccagttatac ccattaaaat aaatattatt cctaaatcta
    34921 tttgtaaagc tgttaatgct tgtattcttt caatgcccat gctgaacttt aacaaatatg
    34981 cagttgtaag agttatagaa gctgtaatcc agccaggtac aactgggtct cccataaaaa
    35041 catgcaaaca gtataatatt gagttaatga tagccatact ccatgccact tcatagggta
    35101 atcccaaaat ttgtgtacta aggccaattg tgcctaaact tgtcatactt gatattatac
    35161 cttgaatagc ttctggtttc tcaaatctgt aatgtataaa tggaattctt atcttaaaca
    35221 ttccaaattt tatatgaggt tgttcccttc tagcgagtct ttccataact tcactccacc
    35281 tttcaataac tcttataagt ttacaacttt ataattgttt ataaattatc aatgtcatta
    35341 aaattagtat ataacatgca aattatataa acaataaatt aaatctataa aattgataga
    35401 ttttgtgcat atatagaaag accgcttcat ttttagttac ttaaatcact taatagtagt
    35461 tatttaaatc acttgataaa ggttttttat aaaattcaat agttctattc catgattcaa
    35521 actgtccttt tgaatttcct tctacagttc cacctgaaga aaaaatccct ccactcatac
    35581 tcatacataa agtctccttt agaggcataa tatatggaat tggtaacgga tgacccatat
    35641 tattgtatgt taataattct acgttatatg gataattatt ttcttcaaag atttctaatg
    35701 cctttaaaca agcttcataa ctattccata tgttatcttc ttttccagca atcataagta
    35761 tatctgcttt ggaattttct atttttattc tagcctcttt tctattctct gctcttttaa
    35821 gacttttctt ataagtacta ttaaatccaa atggaatacc ttttgatata ttttttttct
    35881 gttcttcaaa gaatatatca ttgtctactt tgatatatgg aaatggctct cctttatatg
    35941 accatgatga agtatcattt ccactcatca atccattaag agcttggaaa caataaatgt
    36001 gaggttgtga tactacaacc tttttaattt gttcatatct tgaagcaagt aaaaaggcca
    36061 attctccacc ctttgatgtc ccatgtacaa atatttcttt agtactggta atttcatttt
    36121 cactaatcca ctcaaatact ttttcaaaat attctaatgg aacctcttct aatttatctg
    36181 gtaacccttc taaagcaaag tatgcaactg ttagtacatt gaatcctcta gatgcaagtg
    36241 gagctgctaa aaggtctaga gcgtctaaat ttccatcaga accacctagc attaaaattg
    36301 ttttattatt agaattttgt ttataaaata attttcctat aaactcatca gatatatatt
    36361 ttgtggtaat atcttctgat ttaaatattc tctttaattc aacttctttt ctttcaatag
    36421 aagtttcaaa tatcatattc ataattattg gtttatcaat agatatattt tctgcaaaat
    36481 ttttaccttc agttttagat ttttccagcg aataaattaa ccccatacaa ttatcagcct
    36541 tataagtacc ttctataggt tcaactaaat ctaaatctac ttctcctttt tcatttgaac
    36601 aaaacactcc ataagatgaa aattcttctc ccttgcacca tggaaattcc attttcacac
    36661 ttattttaag tttagtattt ggaattaagt ccgaaaccat aatcttaagt ctttcatcca
    36721 caaatgattc tacattgtat acatttactt tcataatcta tttctcctta taataattat
    36781 ttatgtttta tataaaacag ctttatctaa tacaacataa ataaattttt aaattaagac
    36841 accatattga ctatttcatt ttatcaacat attctatttt tgtcaacata ttgtcttttt
    36901 tagcaattta aaattatgta gtctatatga aatccagttg atttttggct aattaaagat
    36961 aggaatgcta ttaggtttag aatatatata ttcaaaataa aaaaccactc attttaagaa
    37021 tggtttttaa tataaactat ttgttattaa taaggatatt tttttattta aatttatata
    37081 atcgaacatc taatatttaa tgtttaataa aattatgcat ttgcaaaagt atatatggca
    37141 ttaactcttg ctacatataa attctcatca ctacatccaa tatatctagc atatttttca
    37201 atcttttctt ttgcattttc aacatcattt tcatcgctct ccattaactc atttatataa
    37261 atatccatta atgacgcttt atattctctt atatcatagc ctaaaaattc agtcaatctc
    37321 tcaatttcct tactaaaatc tccatcttct tttaccaaaa attcgtatac atcttcccta
    37381 tatggattta aagttattat ttgttttact actttgcatt cgtcagcctt cccaataaaa
    37441 ccatctttat aattattaaa taaggcatta gattttttta tagattcttc atcaatataa
    37501 gaatgtaccg cagttatacg attttctata agggcatcta caacagcata atgaatttta
    37561 aaacaatcat tgtataaata attgctcatt ttctttattg tcgattctat ttctaagaag
    37621 ctcgcgtggc catttttttt atttttattt ggtataataa aagttttatt caagttatta
    37681 aaaagtctct taaaatctaa atatttttca caataaacac ttttaaaggt attgatatct
    37741 atagttataa ttccaaaact tactatagtc tcaattcctt tcttaaaaga ctcttctata
    37801 tatttttctc ctaaacttaa acctctatca gatatttgct ttagattttg aaaactattt
    37861 aaacaatctc tctcaaagtt tttagatatt tccaaagcat ataatttaaa gattttcctt
    37921 atcttattat aattattttt tgtatcatca aatctgataa tagctccatt tacatcaaaa
    37981 gtaatcattg agttttaacc tccccattag tttcatcaat aaaataaatt taatataaac
    38041 tttataatca taatattaaa cttatttata ctataattat taatttgatg ataaaagcta
    38101 ttttccttct aaataaaaaa tttgtctaaa gtttctaaaa aatttagaca aatcttaggt
    38161 tattactctt taaattattt ttaaattatt tttaaattat tccaaatacg ccaaataata
    38221 ttggtataaa tatagctggt aacaaattgg ctacttttat attcgttaat ttaagtacat
    38281 ttagaccaag tcctataatt aataaacttc cagctgctgt catttctgtg actacaggat
    38341 cacttaaaaa tccatttaaa aatgatgctc ccacacatat aataccttca tacaaaaata
    38401 cagatattgc agaaaacatt acacctatac ctaaagaagc agtaaatata attgaagcta
    38461 ttccatctat aacagatttt acaaataaag tatcatgact tcctgtaaga ccactttcta
    38521 atgaaccaac tactgccatg gctcctatac agaataataa actagatgat ataaaaccct
    38581 ctgctataga atctttttta tttcctttag aaaatttact ttgtaaaaaa gcacccaact
    38641 tatttaccca tttgtcaata tctattaatt ctcctatcag agcacctaca gctacggata
    38701 ttattgtcac taatgtgttt tttccttcta gtgctcctga tataccaatg tacaatacac
    38761 ataaggcaat tccattcatt atagtatcgc ttactctttg aggtaatcct ccttttatta
    38821 taagacctac tatacatcca cctgcaattg ctagactatt tgctattact ccaaacattt
    38881 tttctcccct cgattagcta attgaaattt atcctattat taaaacctaa acatctatac
    38941 tttgtattgg atattttaaa tattccaaaa attcttcaaa accttttcta gatatattta
    39001 cagttttagt atttatgtta ggatgaaaat ttaagtaatc ttctttaatt acatctttat
    39061 ctatgtaaag ctcaactttt ctttctgtat catttattaa tgaaaaagga tttacacttc
    39121 caggaagaag tttaagtaca ttgtatagtc tttcaggtga agcaaacgat aatctagaac
    39181 ttcctatctt atctttaagt gagtttaaat caacttgttt ttctccttta actacaataa
    39241 gataatactt atttcctttg gcatttctta aaaataaatt tttacattga cacccctttg
    39301 ttattccatc taaaatgact aattgctctg ctgtatatac agcttcatgc tctactacat
    39361 catattcaac atttaattta tccaaaatat catatatttt agtttcattc atgctagatt
    39421 cattttcatc ttgttctttt ttattattta aatcactcat acttttctcc ttaaacactt
    39481 catcataata tcattgtgag gtattattct actatagcta ttgctcttac tggagctcca
    39541 tcagcatcat tatacttaaa tggtgctgct ataaatagaa atttttctgg aacattttct
    39601 aaatttgtaa gattttctat gattattttt cctttttcaa ataaaatatg atgcacttca
    39661 aatactgatg tgtcatatct atccactgat agcatatcta ttcctatgcc ttttatatta
    39721 gtattagcta tatagtttgc agcttctttt gttaatgtag gataacctac atagtactgc
    39781 tttttatccc aaaattttga ccaacctgat ttaaatatta taaaatcact attttttatt
    39841 tcatcttcat atttttttag atattctaat tctatattct catttccctt ttcaagttcc
    39901 aatacataag ctttcccaac aaaattttct atatccaact tatctagggt ctcaccttta
    39961 gtatacatat gtcttggtga atccatatga gttccattgt gagaaaatac actaattaat
    40021 gtttcttgat aaccattttc ttcaataata gctactttct tgatatctgg tctattaggc
    40081 tctgcatata caggcatgtc attatgtgtc acatgagtta aatcaaaaac cttcatcttt
    40141 atataccccc tatgttttta ttttctatta tatacctaaa ttcattttat ttctatcaga
    40201 ttttattcca ttatatacca tactactata tattttttat aaacctcaag ggatttaccg
    40261 aaaaatcttg gaaagaatta tcagtaaata taacatcttc acccaaaaaa cgtttatacc
    40321 ttccttcttc tttctttaaa gtaattctct gtttttgtga atgattatta aaaaccatta
    40381 tcttaagagg aggttttttt ctattagtct gcactctttt taacatgtat tttatgtgca
    40441 tatcagcttc aggaaatgaa tatccacaaa atattaaaag gtcagtatct cttaaagttt
    40501 tttctgtttc attccaaaca tcacttaaaa atatgtttga catattctta aaatatgttg
    40561 gtggcactat aataggttct gttaactcac cacactctaa acattttgtc tctgaactat
    40621 tttcaataag cttcatgaca ccaccttcat gtggtgtaag agttacacta ttacaaatgg
    40681 ggcaataaag ccaattcaat gacccatgta tcttatataa tttgattaat ggttcttttg
    40741 gttttctcca atttaactcc tctttaaaat ttgtaaactc cacaccataa tcaagcataa
    40801 ttggcaaatc attcttatct cttaatccag taactgtatt gtctatatgt atatcataat
    40861 ttgcactaat aaaagtagta tcaagaagca aatcattttc caaaagattt tcaactaaaa
    40921 gtttatgata tttattatct gttctaggtg tattatgaat tgcttcagcc attagcagta
    40981 ttaaatattg tcttaaaaaa cgtatactat cacttctgtt atttagattt tctagtccaa
    41041 aatttctaaa tgcttctttt ctttgttctg ctaagtctaa aagacctaaa acttcttcaa
    41101 aggtaggaaa atttgcatta tctatattat cttttactat atcaatattg aacatctgtt
    41161 taaagaaaat atacaattct ctattcattt tggtattata atttgtggga tttagttttt
    41221 taaaatattc gctaaaaagt tcattttgaa taggtagatt ctctgctgct gaagctcctg
    41281 ctcctaaaaa tattgctatt ttcatatagt tcctcctaat ataaatatta ctcctatttt
    41341 tatatccatt aaatatccat atcatttatt ttatgataca acaataaagc tgtcttttac
    41401 tagaaaaaat cctattacaa gacagcctta tattatatta aatctttaat aattcgtaaa
    41461 tagaaagagc atatatttga gtagctttta taatatcctc tactattaag tattcattag
    41521 cttggtgttc tgtttctggt tttcctggaa aaatagctcc aaatgcaaca caattatcta
    41581 aagctcttgc gtatgttgct cctccagatg aaagtggtgt tccatcaaga ccagtttctt
    41641 cttcatatac ttttctaagt gtcttaacaa gaagagtatc ttctggaaca tagattgaat
    41701 ccaagaaatc atattcttca taatttaaat tgtatttatc tgtcattttc tttaactctt
    41761 ttacaaaatc atcctttttg tatgttactg gaatccttac atctattcct gcaaattctt
    41821 tttcgttatc aatagttact ctacctatat ttactgttag tttacctgat acatcatcct
    41881 tgcagttagg aattatattg tttccattag catcttcacc aataacttct gctaaaaact
    41941 taattatatt agaatctata cctatattat taagagctat acaaagtcta gccactgcat
    42001 ttataccagt atcacttgct gctgaatgga cactctttcc aattatacag attttattac
    42061 cttcaacagt atactcaaaa tttaatttat taagttcttt ttttaattta tcagagtatt
    42121 ttccaatata gattgcttta cctggaactg catttaaagc ctttccaact gacaactcta
    42181 tatcactttt gctatcacaa gtcaaatgaa cttgtaaaag acctttctct gcatttgtta
    42241 ttgggaatct agaatctgga gtaaatccat agtttggtat ttcttcatta ttttctttat
    42301 atttatttat acatctccaa agattttctt catcagcccc aaaaatgaat cttatcctct
    42361 tattaaagtc tacatttaaa tccataagag ctttcactgc ataaattgct gatattgtag
    42421 gtcctttatc atcttgtgtt cctcttccat acaatttacc atcttctaaa acagcttcaa
    42481 atggagggta attccagctt tctaaatcac cttctggaac cacatcaacg tgaccaagta
    42541 tacctatcat tttttcacct tgtcctattt ctgcatatcc ataatatcca tctttgtata
    42601 ctgtcttaaa tcctaaagat ttacataaat ctaatatacc tcttaaagct ttatctacat
    42661 tttcaccaaa tgggcaattt tcagttgctt cagatataac actaggtatt tttacacttt
    42721 cttgtattga agaaatcatt tcatcttgta gagaatttac tttttcttta atttgctctt
    42781 tcatattatc acccttcaat tttcatcata atatactaat aaatattttg accttttaaa
    42841 aaaaaaatat gcttattttt tcagtttttt tataaattca atcgctttta aagtccccat
    42901 ttttgaatgg tcaaatgtaa gtccaccttg gaaataaaca ttataaggag gtcttattgg
    42961 agcatctgca cttaattcta tagaagaacc ttgtataaat gctcctgctg ccattatgac
    43021 ttcactttcg tatccaggca tgtcccaagg aacaggtttt acataagaat cgactggtgc
    43081 agcttcttgt ataccttcac aaaaacttat tacttcatca gcattattaa gtctaataca
    43141 ttgaataata tcacttctta agtcatcata ttttggtaat acatcatatc ctaatttttc
    43201 aaaagctctt gagcaaaaga tagctcccat tacagcctga gatactatat aaggcgccaa
    43261 gaaaaaaccc tgaagtacat ttctagttgt tccaaaagta agaccacatt cttttcctat
    43321 tccaggagaa gtcattctat aagatataag ctcaatcaaa tcttttctac cagctatata
    43381 tccacctgtc aatgcaagcc caccaccagg attttttatt aaagagccag ccataacatc
    43441 tgctccaaca tcagtaggct ctttggtatc taaaaactca ccataacaat tatcaaccat
    43501 tactatagct tctggtttaa cagactttat tacttctata gcttctttta tatcactaat
    43561 tgaaagtgat tttctccaag aatatccttt tgacctttgt atcataacga gtttagttct
    43621 atcatttatt ttgtttttaa ttccttctaa atctaagttt ccatcctcta aaaaatctac
    43681 atcatcatat gtaacaccat actctttcaa tgaacctttt tcttctctta tgcctataac
    43741 tccctctaaa gtatcatatg gtctaccagt aacagataaa atttcatctc ctggtctaac
    43801 tataccttgt atacataaag taagtgcatg tgtaccattt acaattattg gtcttacaag
    43861 agcatcttct gtattaaata ctttagaata aatttcctct attttttcac gaccaatatc
    43921 attatatcca tatcctgtag tccagttaaa gtgcatatca cttagtttag attcttgcat
    43981 agcttttaaa actttatatt gattatattc tcttatttct tttatttctt caaacttatc
    44041 ttttatttct tccattattt cttgcgatag tttaaaagta tcatcatcta ttccatagta
    44101 gtcttttaat aattcttttg tctcattaag cattttatca cctgtctctt tattatttta
    44161 tttaaacatg taaaggagac tattttacta aaacaaataa attatagttt ataagttagt
    44221 ataagtctcc tctcaatcat cttaaattaa attaattatc tatctgttgt tattattatt
    44281 gttgttttgg ttttgatttg ttagattaat atactttcca ggttgtatag ttgatacagc
    44341 atgtttataa atcatgtttt gttgtctatt atccccttct attaatatta tataactatc
    44401 aaaccccttt acaagccctt taacttgcac tccattaact aaatatatag taacaggtat
    44461 cctttctttc cttgcattat ttaaaaacaa atcttgtaaa tttaaaactg tatttttcat
    44521 tagatttgta ccctcccaag attaaattga acttctaaaa tattcctacc ttatattcta
    44581 tataagttat gacaaatttt caatattaag ttgtatactt aaaaatttat atattatttt
    44641 atagaatctt taatatataa gattatttca ttttttaatt cgtctatatt ttcatattgg
    44701 tctaaatcaa accattttgc tgttttatat cttttaaacc atgttatctg acgttttgca
    44761 taccttctag aatctctttt aattatttca atagcttctt cgtatgtata ttctccatcc
    44821 agatacttta atatctcttt ataacctata ccttgcattg atatcatatc ttttttaaat
    44881 cccatactta aaagtttttt tacctcttca accaatccat ttttaagcat aatatcaact
    44941 ctcatattta ttctttgata caaatgttct ctatctctat ttagaactat tattattggt
    45001 tgatattctt cattaaattt taaatcactt gaaaaatcat tcattttctt accacttaga
    45061 caaacttcaa gagctcttat gaccctttta gtattgtttt tatggattct attagcagat
    45121 tcttcatcaa gttcttttaa cttattatgc atgtaatcta ttcccttttc agcaagttgt
    45181 ttttgaagtt cttctcttaa ttcattattg gcatcagatt gtgcaaaatc catattatat
    45241 attaaagagt ttaaataaag tcctgtgcct ccagttacta aaacacattt ttccttttta
    45301 tttatttcat gtatatattt ttttgctctt tgttgaaact ctgaaactga aaatggatag
    45361 tcaggcttaa cttcatctat aaggtaatgc ttcactcctt gcatctcttc ctctgtaact
    45421 tttgcacttc caatatccat atattcatat atttgcatag aatcagctga aattatctct
    45481 gcattcatat cttttgctaa ttttattgac aaatctgttt ttccaacagc agttggacct
    45541 gtaagtatta taagtggtat ttttttcata acattccttt ccatatattt taaatatcca
    45601 aatattttac ataattcttt taaacatttt ttctatttct gtcttagata tttcgaccat
    45661 tataggtctt ccatgaggac atgtaaatgg attctcacac ttttctagct gttccaataa
    45721 actttttatt tcaatatcgt atattttatc atttgctttt atagcagacc tacatgccat
    45781 agatgcaaat ctctctcctt ttaaatcata attacttgta atttcttcta tattatcaat
    45841 tatttgaagt ataaatttct cggtttcagg tactccaaat atagtaggaa cacatcttac
    45901 cattatatga ttattgccaa aaatttctag ctcaaaacca aatttcataa ataactccaa
    45961 gttattttca atttgaagca tatctacatt tgatacttca ataaccactg ggtctaaaag
    46021 tatttgcata tttatatctt gtctatagaa cttctccata tatctttcat atagtattct
    46081 ttcatgtgca gcatgttggt ccaacaaata catagaatcg tctttgctca aaattatata
    46141 agtattaaat acaactccaa ttacagaata tccgtataaa gaaaacttgc gttttgaact
    46201 acacaagtat tcttcttcac tgtccttaat actatctcct aagtaataat ttccttcatt
    46261 tttaattcca tcaacttgaa actcttcttg tatattatca tttgcactat cttcacttag
    46321 ataattaatg ttttttacat catcttctac acttgcattt aggacttcac ttactgattg
    46381 aaattcattt attggttttt cacttgataa agtaacaact tcaatgactt catccttacc
    46441 tttagtaata ttactatttt taggagtaga ttctaataaa tcattatttc ttaatttata
    46501 atctgtactt ttttctctac tgttaatagc gattctaggt tgtgtttttt tatcactata
    46561 agtagcatat tttccaataa gatttgagtg tattaattta acctttaaaa aatctctaag
    46621 ttctatatac acttcttgtt ctttttcaaa tttaatttca agtttattgg ggtgtatatt
    46681 tacatctata catgatgggt ctacttctat atttaagaag cacactgcat gtttacctat
    46741 tggaattata gacttataac tttctgttat tgcatctatg attattttac tttttacaaa
    46801 tcttttattt atatagatat gttgtaagtt tttatttgaa cggtatatat tgttattacc
    46861 tatatatcca ttcattttaa agtgattgca cttaaactct acatctatta tattttccgt
    46921 tatttctttt ccatatatac ttctaatagt gtttacaagc tttccatccc ctggagtatt
    46981 tagcatctgt ttattgttat ttgtatattt aaattgaatg tttggattac ctattgcaag
    47041 tttatttatc aaatcactta tatttatagt ttctgcatga gtagatttta aaaatttctg
    47101 tcttgctggt gtattaaaga aaatatcttt tataatgatg gtagttccat tagtagaacc
    47161 tattggttct ttcgatatta tttttccacc ttcaacatat attttagttc ctattatttc
    47221 atctttagtt ttagttgtca tttctaattt tgatacagct gaaatagatg ccaatgcttc
    47281 tcctctaaaa ccaagagagt ataaatcata caaatcatca atttttttaa ttttactagt
    47341 agcatgtctc aaaaatgatt tttcaacttc acttgaaggt attcctattc cattatctgt
    47401 aatcttaatt agactttttc ctccatcaat tatatctatg gaaattttat ttgcacctgc
    47461 atcaatggag ttttcaataa gttcttttac tacagaagaa ggtctttcta caacttcacc
    47521 tgctgctatc ttatttatag tcaaatcatc taggatgtta attatatttt tcatttttac
    47581 acctctaaga ttttatttct tttgcttttc tttgaagatt ataaagagag tttatagcat
    47641 ctaatggagt catatttaaa atatccagat ttaaaatttc ttctgatagt atatctctat
    47701 ttacactatc aaaagagatt tgagttaagg ctacttcttt tacagaatcc acttgattaa
    47761 ttttctcttt atcatcattt tgctttatta aagcaacttc atcatttaat gctttaaatt
    47821 tagaatttaa tttatcataa tcctttttta tatgtttgta gtcttttact ataagttcat
    47881 gttctatttt tagagattca tatttattct taaaattact ttgatttacc ttaactaatt
    47941 cttcgtccaa attactatta attatattat tgttttcttt atctccattt attgcaacac
    48001 tgttgtaaac atgatttttt tccaagtctt taagtatata ttttgctctt tctatgactt
    48061 cgtctggtaa tttagctaat ttagcaacat atattccata actcttgtct gctccctgag
    48121 gaattatttt tcttaaaaat attattcctt ccccatcttc tttgactgct attgaataat
    48181 ttttaacctc tttaaactct tcttctaaat cagtaagttc atgataatgt gttgcaaata
    48241 atgtcttaca tctaatattt ttttgaatat attccactat tgaccatgct aaacttatac
    48301 catcataggt actagttcca cgacctattt catctaatat aactaaactt ctctctgttg
    48361 cattttttaa tataagggat acttcgttca tctctaccat aaaagtagat tgaccttgag
    48421 ataaatcgtc actagctcca actcttgtaa atattctatc taatattgga atatcagcag
    48481 actctgctgg tacaaatgag cctatatgtg ccataagagc tattatagca gtttgtctca
    48541 tatatgttga tttacctgac atattaggac cagttattat gttaataatg ttttctccac
    48601 gatttaaata agtatcattt ggaacgaaat tttcctctcc tactatattt tcgacaacag
    48661 gatgtctacc atttcttata tcaagtttat tattttcatt tattgctggt tttacatagt
    48721 tatttatatg tgcaactgtt gcaagggaca caaaaacatc tatattagct atagtcttag
    48781 ccactttttg tattctatct atgtttttat atattgtatc tcttatctct acaaatatct
    48841 cgtattctaa agatttaatc ttttcctctg catgtagtat cttttcttct atttccttta
    48901 attctggagt tatatatctt tctgcattac taagtgtttg ctttcttata tatgtctcat
    48961 ctagctttgc ctgtttaaag ttagcttttg ttatttctat ataatatcca aaaactttat
    49021 taaagcctat ttttaatgat ttaactcctg ttttttctct ttccctgttt tctatttcct
    49081 ttacaagaaa ggctccattc ttagaaatct ctcttagttc cttaagttca tcactaaaat
    49141 ctgatttaat tatgtttcca tcttttatgg ttatcgtagg ttcttctaga atagcttcat
    49201 ctattaaatt gtatatatca tctaatttat ccatttctga aacatactct tttaggattt
    49261 ttgcatttga taaatttata gtatctttta aattaggtaa cttttctatc gaatttttta
    49321 agtgaattaa ctcttttggt gttactctct caaatgctat ctttccacat attctttcta
    49381 tatcgtatat atttttaagt atatcattta ggtcttctct taatataaag tcatctttta
    49441 tttcttctat tacatctaat ctattttcaa ttttagattt atttatcaaa ggttcttcta
    49501 catattttct taaaagtcta cctcccattg ctgtagaagt tttatcaagt acgtgtaata
    49561 atgaaccttt tttcttattc cctcttatag tttgagtaag ttctaaatta gttctagtaa
    49621 acatatctag aaccatatat tctgatgaat tgtatatatt tatattatta atgttagatg
    49681 ttatttgttt ttgagtattg tatatataat tcagaagaat tgataagctt gactttatta
    49741 gacctttatc atcaaacttt agtttttgta gataaacatc tggaaaatat tcttttaata
    49801 tatttatatc caaatagtta tcactaaaac tttcatttat gtatatatta cttacagtag
    49861 ctatatctct aagattttct ataaagtcta aatcatttat aattatttca gttggatgga
    49921 tttttgcaat ttcttcaatt accttatctt catttaaaca tgttgcatta gtttctcctg
    49981 tacttatatc aacataagtt agacctatat tagtaccatc cttatacaaa gataataaat
    50041 aattattctt tttattttca agtaaatttc catctaaaac tgtaccagga gtgatgactc
    50101 ttataacctc tcttctaaca attccttttg ctgtagatgg gtcttccatt tgttcaccta
    50161 ttgctacttt atatccattt tcaactaatt ttgatatata tgaattggct gagtggaaag
    50221 gaacaccaca cataggagca cgttcttcta aaccacaagc ttttcctgtc aatgctattt
    50281 caagagcttt tgaagctact aatgcatctt caaaaaacat ttcataaaaa tctccaagtc
    50341 taaaaaacag tatacagtct ttatatctat tttttacttc aagatactgt ttcatcatag
    50401 gagttaattt attcatatct atttgcatta tcaaacctcc ttcttttcta attaaatatt
    50461 atatcatagt agatgattat tattaacaca atatataaaa ttttgacata taactaaaaa
    50521 caatccaaaa tgtatactca cattttggat tgctaagttt aatgcttatt aaataaaaat
    50581 atttttttta caataaagat attatttctt ttttaagttt aatgatattt tcaaggttat
    50641 cttcatttaa ctttctacta tctataacaa attctttctt tactattgat ggtttttttg
    50701 aaataacata aattctgttt gatagcatta tagcttcgtc aatatcatga gttataagaa
    50761 gtattgttga atttactttt ttcttaacat ctaaaagcca tttttgcatg gatgttttag
    50821 ttaatgaatc aagtgcccca aaaggctcat ctaaaagcat tatgtcatta gaatttataa
    50881 aagttctcaa gaagttagct ctctgtctca ttcctccaga aagttctgaa ggatatttat
    50941 cttcatatcc gcttaatcca aacacctcaa aataaggttt taccattgac ctagctttac
    51001 tctttttttc tttttttaaa attagtggta gtgacacatt atctattata gttttatatg
    51061 gcaagagtaa atctttttga tacatataac tatacttacc atttatattc actttgccac
    51121 tatcataatc tgtaagttta gttataatat taaaaatagt actttttcca catccacttg
    51181 gccctaatat agaaacaaac tcaccttcat aaacatcaat acttatatct tttaaaactt
    51241 caatatcttt ataagttttt gatacatttt ctatagatac ttttactttt ttattgtggt
    51301 aaaaattcat ttgtgtaagc atcacttgcc ttcatatcct tatctattaa tttatattct
    51361 tttaagaatg atgtatagtt gttccataca ctatctttca tttctcccca tcgtggtgca
    51421 tcatctttgt acttgcttgc taaatattct tgactcttta aagctagttt ttcatctact
    51481 tcaggtgcat gttttactaa aatttttgct gattcttctg gattttttat tgcatattca
    51541 taaccttttg ttgtagcttt taagaatttt ttagcaagct ctggattatc tttaagcaca
    51601 gtttcattag aaattataag tggtgtataa taatccaatc tctcatctaa atcttttact
    51661 ggtataaagt ttaagtcata tccaattaaa tcagctttaa ctgcatccca accttcaaat
    51721 atccatgcaa aatctacagt tttcatagct gcaaagaaat catcttgacc agtattaact
    51781 atctttaact tattaaaatc agctccattt ttcttcataa ctgctttaaa aacagcttct
    51841 tctgatggag agccccaacc accataagtt tttccttcaa aatctttagc tgttgttata
    51901 ttcttttctt ttggtgatgc aaacccagaa gtattatgtt gtataacagt tgctacagct
    51961 tttattggaa gtggatcttc actagtcttt gcataagtaa cttgttcttg atagcttata
    52021 ccaaagtcag cttttcctgt tgctactaaa gtttctgctc cactttcagg tggttgtact
    52081 atttcaacat ccaaaccttc ttctttatag taacccttat caagtgctac aaataatcca
    52141 gtatgatttg tatttggtgt ccaatcaagc accatagtta cttttttaga agaagtatct
    52201 ttatcattgt ttttgtcttt attgttattt gaagaacatc cagttattgt tgccaatgta
    52261 aaaacactta ctaaacctaa tattcctaac tttttaaaat tcataattgc ctccctcaaa
    52321 tacctttaat ctattaatct atgtcttata acaacttttt ttacagcctg tacaattcct
    52381 acaaacatta aactaaatat aactactaat atagtagatg caaatacttt atcaagtgca
    52441 tatgcacttt ttgacctaag catataaaca ccaagtcctt tcgttccacc tagccattct
    52501 gcaacagttg ctgccattac agcatatgtt gcagatattt taagtccaga aaaaaattta
    52561 tccattgcca taggaaattt aaggtgaatg aatgtattaa ctttatttga gtccatagtc
    52621 ttaaataaat ttaaataatc tttatcaata ttctcaatgc catctacaaa acttattaat
    52681 ataggaaaaa aacaagtaag cattaccatc aatacttttg gcattgttcc aaatccaaac
    52741 catatcataa agagtggtgc tataattatt gtaggtatca tctgtgtaac caacataata
    52801 ggataaagac atttttttat tattgataca aaatccatca atattccaat taccaatgat
    52861 attataattg cgactataaa accaagtatt gcttctccta tagtaaccac agcatgcatg
    52921 gataaatttt gataatcttt aaaaaacaca ttaattatat ctactggtgt gggtagtata
    52981 tactgaggaa cttctaaaac tcctaccata gattgccaaa gaataagtat aaacaaaaat
    53041 gttgctattg gatatatact atctttgact ttatctatga tttctaagtt tttcatctat
    53101 agtcagacct ccagcttttt catctactct agctactgtt atgactcttt cacatccaag
    53161 attaaaaggg attttatgta ccttttttaa taattcaaaa acttcatcaa aatcaccttc
    53221 aacagtagtg ctcattgctc ctatttcaca tttaagacca cttttttcaa tttcagcaat
    53281 acaagcatct actactttat acatctcttc ttcacctttg taaggtctta gtggcattac
    53341 tgctatgtct gcgattacca tttaaatcac tcctttaaaa ataattaata cctactaggt
    53401 atattttgtt ttttattaaa aaattttatt actaaaaaga tattatattt aaataaaaga
    53461 aaagtcttat ccaaaatagg ataagactta tttttatctt aactggtctc cctacactgg
    53521 cattatccaa acaggttcaa agggtcgaga taaaatctcc tctcagcaca ttagctcccc
    53581 gaaatatatt atatcttttc tacttgatta tactacactt atcatatttt aacaaatttt
    53641 ttatttatat tagatatttt atccgttcaa aaatatctaa tataaattgt acattattac
    53701 accaaataaa ttatcttaaa atggtatttt atcaacatct tccaaaacta gattaactga
    53761 attttctagt ttttattttg ctatttcaag catatttgga tgtatatcaa ttccatacaa
    53821 atattgtgct aaatttctgt tttcactcat ctaatttgca atcgttacag attacagatt
    53881 agaaacagtt tttagactct acttatcttt atctacaaaa aatctttcaa taaattcatt
    53941 aataatattc agtaatctaa aaataaacct ctatctggat ttttaagata caaacctttt
    54001 aggaagtatc ttttgtgata atataaaaat tactcgtcat tatcatcaaa atcctcagca
    54061 accaacattt tatataagaa tcaaactcta taatataatt attttatcca atttattttt
    54121 gagaaataaa atattttttt aatttttaaa ttttttaata tgcaccttga aaaaagaaac
    54181 gttttcctat attatggtaa tagtagaata aaactaaata ggcaaaacta gagaaattta
    54241 gtgacgcaaa gctataggga ctaagactta tgaaatgagt tatgtcagcc agttgccaaa
    54301 gagatatttt ctttttgttt ttatgaatgt tttttagggg gatatatgat atatgtttat
    54361 ggataaaatg gatagatgta cacatatact aactgcatat atatgcagtt cacgcgatta
    54421 ctgcaatttt atagatacac aattaaatga ttttatacta gaatatggag agaatgtggt
    54481 agaatcttgt ttgcatcaag tgatggtatt ggtaagcaga tataattaaa gaaattttat
    54541 tttctagaaa acccttttta gttttatcta cgttttataa ttcattaaag aactaattaa
    54601 aataagcttc attatatatt tttcatgaag taaacagtta agtttatctc atatactgtt
    54661 taccccaatt acataattct aataatatag attccaatga tttaccacgt ttagtagaca
    54721 aatattcaac ttttggagga atagtcggat aagaaatcct cttaataagt ccatctcttt
    54781 caagatactt taattcttgt gacagtatct tatgacttat atgaacaact tcttttttta
    54841 attgactgta acgtattggc tcttgtttta aaatatgcca taaaataatt gccctccatt
    54901 tacttcctat cacagtcatg gtaaaaccaa ttgaacaatt aaaatctttt tgtctttctt
    54961 caatatttgg aaattcttca aaattattat ctatatccat ctcaatcctc tctttcaaaa
    55021 tagtaagtat ctaactaaaa agtgcattct tgtttagcgt actaattcgt aatataatct
    55081 tgattaaaaa atagctatgc acactcgtga ctttagtcat gggaggttca gtgtagcata
    55141 gagccttaca taatactact tttttagatg tatatgttta aattttaata tagacatatg
    55201 ttattttatt aattttattt aaacagataa taataaataa taatttatct caagttttct
    55261 atgtagataa actaatctaa tgtttagaaa ggattatata atatgaataa aaaatttcgt
    55321 ctttatcaag ttgactcatt acaaaagaaa aatttacagg taatccagct ggtgtaatta
    55381 caaatgctga tggcttatct gaatcacaaa tgcaaaaaat agcaagagaa ttaaataatt
    55441 cagaaactgc ttttattttc aataacttgg ctaaaaatca tcaagaaaat tatgatgtac
    55501 atatcagatt ttttacacca actaatgagg ttcctatatg tggtcatgct actattgctg
    55561 cccattatgt tagagcaata gaaaaccaat tcaataacaa aacagtattt caaaaaactg
    55621 gtgctggaat attaccagtt gatattataa aaaaagataa tgattatgaa ataattatga
    55681 cacaaggaaa aattgaagta tctccaccat tacaacaaac ctatcaaaaa agattactta
    55741 atgcatttgg tatttaaagg aagatattcg tacagattgt cctattgcca tatcatctac
    55801 aggacattca aaagttatga ttggaataaa ggaattatca acattaaata gtttatctcc
    55861 aaatttatat gaattatcga aaataagtca agaaataaaa tgtaatggat attatatttt
    55921 tacattacat aataaagaaa ctctacaagt tcatggaaga atgtttgctc ctgcaattgg
    55981 tatttcagaa gaccctgtta caggaaatgc taatggaccc ttaggtgcgt accttgtaca
    56041 ttataaagta atacctacac ccaacacaga gtttatattt gaagcagttc aaggagaagc
    56101 aataaaacgc aaaggcaaga tgttagtaaa agtaattatt ttagataata agccagttga
    56161 agtaaaaata attggaaaag ctgtaattgc attctcaaca aacatagaaa tctaattata
    56221 gattccttct aagtaaattt ttgaactttt taatactaat ttaataacaa actaatttat
    56281 atacaatcaa attaattttt ttattattt
//
LOCUS       DAEHWM010000016        54702 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.017, whole genome shotgun sequence.
ACCESSION   DAEHWM010000016 DAEHWM010000000
VERSION     DAEHWM010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 54702)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 54702)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..54702
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.017"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(152..751)
                     /locus_tag="KNP36_000996"
     CDS             complement(152..751)
                     /locus_tag="KNP36_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HDOD domain-containing protein"
                     /protein_id="HBF0872884.1"
                     /translation="MYPNKEIAIEELEVAGKMNPGPWIKHSYNVANVAKLIAEQCENL
                     NSEKAFVCGLLHDIGRRTGISSVRHIIDGYDYVISKGWDEVARVCLTHSFPVKDIEAD
                     IGNKDISKEQYDFINHYLNNLEYNDYDKLIILCDALADANGFCILEKRFVDTTRRYGI
                     YPFSVERWNKTYEYKEYFEKIINKSIYTLLPNIEKSIYY"
     gene            complement(847..1500)
                     /locus_tag="KNP36_000997"
     CDS             complement(847..1500)
                     /locus_tag="KNP36_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0872885.1"
                     /translation="MKVDPLTTQVYDYISKKIQNGEYEANQRITESEICKSIGVSRTP
                     AREALTRLAGENLLEKIPNKGFVVKEFQEKEKLDTYSVIGVLDALAGSSALQNLTESD
                     LVKMEELTEMMAVSIKYKNYNSYLKLSNEFHDIYITKSDNQVLVNLLNSLRYNFMSKS
                     YTSDNEDELYKMLTYSNNQHIEVVKSMRENDLENVERILREHWKTIPMEEMKKEKLL"
     gene            complement(1745..3610)
                     /locus_tag="KNP36_000998"
     CDS             complement(1745..3610)
                     /locus_tag="KNP36_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="HBF0872886.1"
                     /translation="MQSVIEYNSWDKNFKAPFGALKFDEELTICVKVNEGYNIKSISL
                     EINREEEMRTITLNEELDNDKLGKCFCGKIEKFDGTGVYFYYFKVDVEMDGQIKTLFY
                     GKNRDNGYSCEYNYSDINKYQITVYKDFKVPTWYKEGILYHIFVDRFNNGNRSGKVDN
                     PKKNSFIYGNWEDTPMYIKDSQGDVIRWDFHGGNLRGIINKLGYLKKLGVSILYLSPI
                     FEASSNHKYDTGDYKKIDPMFGDEDTFKELIDKAKEKGISIVLDGVFSHTGADSKYFN
                     MYGNYNSLGAYQSKESPYYSWYMFEEFPQKYKSWWDVKTLPNINELEHSYMDYIIYDN
                     DSVINKWVNMGIKGWRLDVADELPTKFIRELKKELKKADDDSILIGEVWEDASNKISY
                     GQRRSYLLGEELDSVMGYPFRNNMFSFLKGEINSYELCNRYMQIKENYPKESFRSNLN
                     LIGTHDVTRAKTELNDDVDLVKLAVAIQMTFEGVPYIYYGDEAGLCGGVDPDNRRTYP
                     WKNEDEDMLNFYRDVIRIRNKNKLLSSGNTEFIYTNNDSVFSFIRVNENNDRMLILVN
                     RSENVESISLCIESSFIEEIPIKYSLKNANSTIQIENNELKVDLDSKSFRIFRVN"
     gene            complement(3615..6035)
                     /locus_tag="KNP36_000999"
     CDS             complement(3615..6035)
                     /locus_tag="KNP36_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan phosphorylase"
                     /protein_id="HBF0872887.1"
                     /translation="MVTISKKKFKQKFEVKMYSLYAQSIKEATDEQLLNVLCSLLKDE
                     IAKKWVATKLDKKKEVYYFSLEFLIGRQLKSNLLNLNIEEEVREGLSELGINLDDLIE
                     AEVDPALGNGGLGRLAACFLDSMASLNISGQGYGIRYKYGLFEQKFVNGYQVEVPDNW
                     LTEGRYAWETVRPNEATMVKFGGEVELIKEGSHLKVIHKNYLPVMAMPYDIPIIGYQN
                     QCINTLRLFKSEIPKRDFGELTSNALNYSGSYEEALKHKYYTEEISQVLYPDDSNYAG
                     KLLRLKQEYFFVSAGIQDIIRKYKKNKLNINNLFDKVAIHINDTHPTLCIPELMRVLL
                     DEENLSWDEAWEITKKTVSYTNHTIMSEAMEKWPVSMMKELLPRIYMIIEEINRRYVE
                     ELNNKGYDQDRIKRMSIIDCDNINMANLCIVTSHSVNGVAKLHTHILETEVLKDFYQD
                     EPNKFNNKTNGIAHRRWLISSNPQLSNLITDLIGDSWKKDTLQLKNIEKFKNDSSVLQ
                     RLDDIKYNNKANLAKFIKDKYDLNVDPSSIFDVQVKRLHAYKRQLLNIFNVLHMYHEL
                     LDNPNLNLDPRTFIFGAKAAPGYYLAKCIIKFINSVASTINNDVRVKDKLKVVFLENY
                     GVSLAEIIIPAANVSEQISTTTKEASGTSNMKFMMNGAITLATLDGANVEICEQVGKE
                     NMFLFGLSAEQVLNYNKYGGYSSLDLYHSNMDIKRVVDDLINGFIPNLGEEGRSIYNS
                     LTTYNDEYFVLRDFENYGQAQADINRLYRDKEKWNKMSLVNIANSGFFSSDRTISEYA
                     KDIWFKRV"
     gene            complement(6049..7491)
                     /gene="glgA"
                     /locus_tag="KNP36_001000"
     CDS             complement(6049..7491)
                     /gene="glgA"
                     /locus_tag="KNP36_001000"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011053260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HBF0872888.1"
                     /translation="MKVFYVTAECWPFAKTGGLGDVSYALPKELKKEGVDVRVIMPKY
                     STIPSYLKDQLKEIAVFSVRVGWRNQYCGLLEMELDGVKFYFIDNEFYFRREDERKSI
                     YGYGDDAERYTFFTDAVLEAISRIDFYPDVIHINDWHTGMLPLILKERYATLEGYKNI
                     KTMYTIHNLQYQGVFDKHVLYDILDLPQKYFDNGDIEYYGSINFMKAGINFADKIITV
                     SPTYANEIQTSFYGEQLDGLLRKESGKLKGILNGIDYDLNDPAKDKDIFVHYDVDSID
                     KKVENKLRLQDILGLKKDSSIPLIGIVSRLVSQKGFDLIAYMMPELMREDLQIVVLGT
                     GEHQYQSMFNYYDSNFSDKVSARITFNASLAQQIYAASDMFLMPSLFEPCGIGQMLAM
                     RYGSLPIVRETGGLRDTVTPYNKFTGEGNGFSFKNYNAHEMFFCLKNAIKVFKDKEKW
                     IKLVENAMKTDNSWKKSAKEYIETYRDICD"
     gene            complement(7520..8650)
                     /gene="glgD"
                     /locus_tag="KNP36_001001"
     CDS             complement(7520..8650)
                     /gene="glgD"
                     /locus_tag="KNP36_001001"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HBF0872889.1"
                     /translation="MRNECLGIINLNKKGDPAINKLNYGRPIASTPIAGRYRIIDFAL
                     SNMINSGITKVGIFAKEKYRSLTDHIGSGKDWDLSRKKGGLSIFSPENTKYRNTYSHR
                     EGDIYTILANLDYIEKSEEEYILIAPSYMLCNLNYSQALEYHKKSHNDITIIYKNVNN
                     ANKDFAGNLTLNLDSNNRVINVGNNLGKFPRANICMETYIMKREDFVECIYNIVNKGN
                     YCYLEEFIIEEAENMKIGAYEYTGYLKCVNSVESYFEMSKDLLNLEVADELLYSERKI
                     FTKEKNESPTIYTDSAKVENSFIASGCLIEGTVKDSIIFRKVNVEKGTVIENSIVMQN
                     CVIKSNAKLYNAILDKNTSVSNGKELRGDEKYPLVVEKNTNI"
     gene            complement(8652..9812)
                     /locus_tag="KNP36_001002"
     CDS             complement(8652..9812)
                     /locus_tag="KNP36_001002"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HBF0872890.1"
                     /translation="MKKEMLAMILAGGQGSRLGVFTKRIAKPAVSFGGKYRIIDFVLS
                     NCSNSGIDTVGVLTQYRPLILNSHIGMGSHWDLDRINGGVYVLQPFMNEKEGNWYNGT
                     AHAIYQNMDFVDTYNPEYVLILSGDHIYKMDYSKMLKFHKEKGSKATIAVIEVPWDEA
                     SRFGIMNTNEDSSIYEFEEKPSEPKSNLASMGVYIFDWKMLRNYFKEAEKNPEINYDD
                     FGKNLIPKMLEDNVGMYAYPFKGYWRDVGTIQSLWDANMDIIKSPETLDLADPKWKIY
                     TNTMAMPPQYIGKNANVHRSMIADGCRILGEVGNSVLSHGVVVGKGSKVIDSVIMPNV
                     VIGENVTIEKAMIGECATINDNVQIKNVNNEINVVSEYENIEPRCVLIEGGL"
     gene            complement(10583..11626)
                     /locus_tag="KNP36_001003"
     CDS             complement(10583..11626)
                     /locus_tag="KNP36_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH/Band 7/PHB domain protein"
                     /protein_id="HBF0872891.1"
                     /translation="MGTKIVLSIVLIVVVVAISLTCIRVIKQSKVGIIMRLGKFQKVA
                     ETGVHFLIPFLDKMAYVIDLREIVIDFPPQPVITKDNVTMQIDTVVYYKVTDPVRYVF
                     EIANPIAAIENLTATTLRNIIGELDLDETLTSRDIINVKMRTILDEATDKWGIKVNRV
                     ELKNIMPPQDIQVAMEKQMRAERERREAILQAEGNKSAAILQAEGEKQSAILTAEAKK
                     EAMVRVAEGEKESAILVAEGEAEAIRQTAIAKAQGEAEMIKRTQMATAEGLKLVFSAM
                     KEADIDNNILALKSMEALEKMAEGKSTKLVLPSEAVNFLGTFKGIKEVMSDDNKEVLD
                     IKEVLNDNESLKK"
     gene            complement(11647..12093)
                     /locus_tag="KNP36_001004"
     CDS             complement(11647..12093)
                     /locus_tag="KNP36_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NfeD family protein"
                     /protein_id="HBF0872892.1"
                     /translation="MKLIWLIVAVLFGIAEMLTPSLTLIWFSVGAVILIFLSSFIESI
                     FLQILIFAVISIAMLVVATKKIVKKDKGYKSNTNLQAMMSKKGIVTEEISPNNTGLVV
                     VEHETWTAISIDGEKIEKGSTVEVLKIEGVKLVVKKVDATVNVTNQ"
     gene            complement(12267..13847)
                     /locus_tag="KNP36_001005"
     CDS             complement(12267..13847)
                     /locus_tag="KNP36_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional ADP-dependent NAD(P)H-hydrate
                     dehydratase/NAD(P)H-hydrate epimerase"
                     /protein_id="HBF0872893.1"
                     /translation="MLIGTSKLSRNVDTACVEEVGIPMIVLMENAVISAMKNMDIDMY
                     NSYTVVCGVGNNGGDGLGIARHLNTYGKEVNVFLVGNLEKLSECSKINYNVLLNMGIN
                     IININKNDLSEKNYGEENEVDKIIKVEKQNIIKNKNLTIFKDRVSKSDVVVDAIFGTG
                     LKRDITGIFKEVIDIVNDNSKNTYSIDIPSGIDSDNGNVLGTCIRANKTISFEFYKRG
                     FLNYDTSALIGDVVVEKIGVPDFITRKYHDEEFITDKTFVKNNIRRRDKHGFKSDFGK
                     VSIVAGSKGFYGASFIATESAVKSGSGLVTLISSEDVQEKVSIRLTEAMTLNFEEERL
                     NKLLNSSDAIGFGPGMGDNSQTFDKLLKIVENSNCPIVLDADGLNVMKDRCYKFLEWK
                     NRFVITPHLGEMARLTGDSIGYIREHRVDVAKEFAQKYNLVVLLKGYQTVITDGKKTY
                     INPTGNSCMATGGMGDCLLGMITSFIGQGMDILEATVSGAYIHGYIGDKLSKAMYTVN
                     ATDLISNISLTMKELLDI"
     gene            14646..15548
                     /locus_tag="KNP36_001006"
     CDS             14646..15548
                     /locus_tag="KNP36_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872894.1"
                     /translation="MSGIISVMTQSLILSIMALGVYITYKILDFPDMSADGSYTMGAS
                     IVAFSLTNGISPVVATLMAILCGCTAGLVTGILHIKFKISNLLSGILVLGMLYSINLR
                     IMGKSNIPLFSFKHLFNGEISPIVLALAFVFICKVLLDLFLKTGLGYTLKGVGDNSQM
                     IKSLGINIGSIKILGLMISNGLIALSGSLMAQFLGFSDVNMGIGTLVLGIASIIIGIT
                     LFKKFTFIKDTTAIIVGSFIYQFTIYFAMSLGMLSTDLKLITAIVIIAFLATGNLNIS
                     LKKNKCKASTKNKSEKRGVVDVTN"
     gene            15535..16290
                     /locus_tag="KNP36_001007"
     CDS             15535..16290
                     /locus_tag="KNP36_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003399531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0872895.1"
                     /translation="MLQIKNLSKSFPNPYGEPNTIFENLSIDIEDGEFVSIIGSNGTG
                     KSTLLNIISGLIKESSGQITLDSTTITNLAEYKRTQIVSRVFQDPSLGTCPSMTVREN
                     LSLALNKGKLLNLKKCLRHKTNDLEHLLEGISLDLKKYLDIKVQYLSGGQRQSLSLIM
                     SSLASPKVLLLDEHTAALDPKTSNEVIELTDKIVREKNITTLMVTHNLKHALQYGDRL
                     IMLHKGEVVLDVKDKEKKDLTVEEILEKFEYAV"
     gene            16387..17424
                     /locus_tag="KNP36_001008"
     CDS             16387..17424
                     /locus_tag="KNP36_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0872896.1"
                     /translation="MIKSKKILSLIIAGVLGVSMLTGCSQNDGSNASNENKETDSKKQ
                     KNIGITQLVEHPSLDKAKKGFIKALEDKGYKDGDNIKIDFQNAQNDMPTTQSIASKFV
                     SDKKDLIYAISTPSAQAAYNATKDIPIIMTAVTDPVEAGLVKSLEKPGGNVSGTSDYL
                     SIDKTLELVKTLTPKAKKIGVIYNTSEVNSKIQVDSLHDYAKKNNYEVVEKGISSSSE
                     VNQAISSLVGKIDVLYVPTDNLIVSSMPIVSKVANENKIPIIASEEGSVSSGALACCG
                     IDYEKLGYKAGELAIEVLEGKSVGDIPVTTLDETEIIINEDTLKALDMQKLSADNIKY
                     IKSDENAKSTK"
     gene            18233..19135
                     /locus_tag="KNP36_001009"
     CDS             18233..19135
                     /locus_tag="KNP36_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872897.1"
                     /translation="MSGIISVMTQSLILSIMALGVYITYKILDFPDMSADGSYTMGAS
                     IVAFSLTNGISPVVATLMAILCGCTAGLVTGILHIKFKISNLLSGILVMGMLYSINLR
                     IMGKSNIPLFSFKHLFNGEISPIVLALAFVFICKVLLDLFLKTGLGYTLKGVGDNSQM
                     IKSLGINIGSIKILGLMISNGLIALSGSLMAQFLGFSDVNMGIGTLVLGIASIIIGIT
                     LFKKFTFIKDTTAIIVGSFIYQFTIYFAMSLGMLSTDLKLITAIVIISFLATGNLNIS
                     LKKNKCKASTKNKSEKRGVVDVTN"
     gene            19122..19877
                     /locus_tag="KNP36_001010"
     CDS             19122..19877
                     /locus_tag="KNP36_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0872898.1"
                     /translation="MLQIKNLSKSFPNPYGEPNTIFENLSIDIEDGEFVSIIGSNGTG
                     KSTLLNIISGLIKESSGQVLLNKHNLSNLAEHRRTQIVSRVFQDPSLGTCPSMTVREN
                     LSLALNKGKLLNLRKCLRYKRDFLENLLEGVSLDLKKYLDVQVKFLSGGQRQSLSLIM
                     SCLTNPSVLLLDEHTAALDPKTSNEVIELTNKIVREKNITTLMVTHNLKHALHYGDRL
                     IMLHKGEVVLDVKGKEKEQLTVEEILEKFEYAV"
     gene            20008..21030
                     /locus_tag="KNP36_001011"
     CDS             20008..21030
                     /locus_tag="KNP36_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0872899.1"
                     /translation="MINKKRLASLILAGALSISMLTGCSQGGDSGNSKQESNSKGKEV
                     KKIGITQLVEHPALDATRTGFVKALEKNGFKDGENIDIDFQNAQNDMPTTQSIASKFA
                     SDKKDLIFAISTPSAQAAFNATKDIPILITAVSDPVAAGLVKTLEKPGTNVSGTSDFV
                     SVDKGLELLKIFAPKAKTIGVMYNTSEVNSKVQVDALKEYASKNGFKVVEKGITTSNE
                     VNQGISSLVGKIDVLYVPTDNLVASSMPIVSKIATENKIPVIAAESGPVEKGALACQG
                     INYEKLGYKTGEMAVKILNGESVSDMPVATSDDTDIIVNEDILKALGMEKPSNENISY
                     VKTKQE"
     gene            complement(21194..21751)
                     /locus_tag="KNP36_001012"
     CDS             complement(21194..21751)
                     /locus_tag="KNP36_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBF0872900.1"
                     /translation="MTEKEKMLSGKGYYANDELLVKEREYCKKLTRLFNNTLEDEYEK
                     REDILRQLFGSVGKQINVEQNIRCDYGYNIHVGENFFANYDCIFLDVCKIEIGDNVML
                     APNVQIYTAYHPIDAQLRNSGIEYGSPIKIGDNVWIGGGVIITPGITIGDNVVIGAGS
                     VVTKDIPPNTVAVGNPCRVIKKIEE"
     gene            complement(21757..22833)
                     /locus_tag="KNP36_001013"
     CDS             complement(21757..22833)
                     /locus_tag="KNP36_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfate/molybdate ABC transporter ATP-binding
                     protein"
                     /protein_id="HBF0872901.1"
                     /translation="MSLYVDIEKDLSSFKLKVEIKQEKGTLGFLGESGSGKSMTLKCI
                     AGLEKPTRGKIVLNDRVLFDSEKKINLSTQDRKVGFLFQNYALFPHMTVSQNIELGLL
                     KLSKSEKKEIVARYLDILKLNGFEGRYPWQLSGGQQQRVALARALATSPDILLLDEPF
                     SALDHHLRSNMEKELMNMLKDYKGDILFVTHDIEEAYRVCDDIIVYNKGEGLPKRPKK
                     ELFESPKYLIEAKITGCKNISKLNRLDKNTIYATDWGCELTLNREIGDNIEYVGIREH
                     HIKVLDSNEDLNEKLCFELINIVENPFTYTIYVRKTDLSNECVPIQIELEKSKMRFKK
                     GDRIYLDFPQEYLFCFRYNYNKKE"
     gene            complement(22834..23517)
                     /gene="modB"
                     /locus_tag="KNP36_001014"
     CDS             complement(22834..23517)
                     /gene="modB"
                     /locus_tag="KNP36_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter permease subunit"
                     /protein_id="HBF0872902.1"
                     /translation="MGTDWSPLWISLKTSILSTIITFVIGIFVSYIMANYRGKWKGLI
                     DGLFTLPLILPPTVVGFFLLLLCGKNGFIGKFLLNFDRTLIFSWTATVISAVVVSFPM
                     MYRTSRSAFEQIDNNMLSAARTLGLNEWKVFFKIAVPLAWPGIIGGLVLSFARALGEF
                     GATLMIAGNIPGKTQTMPIAIFFAVEGGDMNKAMMWVMIIVAISIAMILLLNYWSEFQ
                     QKIIGKRCG"
     gene            complement(23666..24478)
                     /gene="modA"
                     /locus_tag="KNP36_001015"
     CDS             complement(23666..24478)
                     /gene="modA"
                     /locus_tag="KNP36_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0872903.1"
                     /translation="MKKILGILGLVACLTLGTVGCNSNEDKKDDGKQEKTTKSSDSVE
                     LNISAAASLKEAMAKIEEEYKKVDSNVKLTVNYGASGSLQQQIEQGAPCDLFISAGQK
                     QMKALDEEKLLVSDTMKDLVKNDLVLISSADSSVSGMKDLTTDKVKKIAVGEAESVPA
                     GKYADEVLTNLNLKDKLKDKLVFAKDVKEVLAWVQSGNADVGFVYFSDTVNNDKIKVV
                     EKTDEKTHSPITYPVSVIKASKNVDAAKKFEEFLLSESGQKIFEEFGYKKVE"
     gene            24671..25600
                     /locus_tag="KNP36_001016"
     CDS             24671..25600
                     /locus_tag="KNP36_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0872904.1"
                     /translation="MDSLSSLTPVEVAELLKITKNTVYELIKRGELPSYKVGKKIRVD
                     TKDVEEYINSQKTGKVKDTHFNNKNIDINNNFKIIISGQDVILDILARSVEKKLDGIS
                     TFRSYIGSYNALYELYNGRVSIASSHLWDFETDEYNSTFVKKLLPGIPCVLINLAYRM
                     QGFYVAKGNPKEITTWEDLTKPSITIVNREKGSGTRVLLDGKLRLLNFNGKHIKGYDN
                     EELSHLGVASTVSRGIADVGLGNEKAALQVNNIDFIPLHKERYDLVIKKEDLQNPVYQ
                     TIINIINSPEFKAELQGLGGYDLTDTGKTIAKV"
     gene            complement(25761..26210)
                     /locus_tag="KNP36_001017"
     CDS             complement(25761..26210)
                     /locus_tag="KNP36_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872905.1"
                     /translation="MKNKNNKDKNMLNIKVLRVLGVLLILFDYTGDTLNFYNFFAKPL
                     VSGNLYKTTGTDCIVFLLFIVECVYLVGRYILKVKINWSEIIENEKGNFINNLLVEKI
                     QEESNIVYNLLNSYVLPNIYKKARGLMFKTYHMLIYIKEKYYYVNIY"
     gene            complement(26413..27393)
                     /locus_tag="KNP36_001018"
     CDS             complement(26413..27393)
                     /locus_tag="KNP36_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0872906.1"
                     /translation="MKNSFKNCISLRNKFIIISIVFLLILLIVSYIFGKLVYNSSVGL
                     EQLIKNEDIVKIFSERKDRPLEKLKNYKTSELMIQSSNNYKLESLFITSNIKTRDTMI
                     LVHGIGSSYYEMLKVAYRYLDKGYNVLVYNQRNTGNSGGDNYTFGLYERYDLDSLVKF
                     VKNKFPEGRLGVHGFSMGAGTAAMHSEINSKDDKVDFYILDSPYSEMKDAIRMGVLEK
                     RIPDILINYVVTCGDLYNKFKSGFWYSDVKPYESVEKSNVPILFIHGTKDTVCNYQNS
                     KKMYDLVKHDKKDLWLIEGIGHVDGFEHDSTVYFNKIFKFIDSNVLSDKS"
     gene            complement(27598..28458)
                     /locus_tag="KNP36_001019"
     CDS             complement(27598..28458)
                     /locus_tag="KNP36_001019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-ADP-ribose hydrolase"
                     /protein_id="HBF0872907.1"
                     /translation="MAMKWRDYADDVNLFEDFDKTIKPLTDEQRRKNINTLIAYFSKE
                     VPSKIYNLSNDEIKPRDILRGLLNVYPPKEIAPEILNMLHNLLLIECEERELVDVNDI
                     EEIEEGIAIWRGNITNLRADAIVNAANNKLLGCLQPLHLCVDNEIHSCAGPRLREDCD
                     KIIKKQGHLEYTGDAKITRGYCLPAKFVVHTVGPIVSGGQPSKEQEKQLLHCYKSCLN
                     TIKEIDEIKNIVFCGISTGVFGYPKKEAANLAVSRVRLWLKENPEKNLKVVFNVFTEE
                     EEEKYRRIFK"
     gene            complement(28775..30103)
                     /locus_tag="KNP36_001020"
     CDS             complement(28775..30103)
                     /locus_tag="KNP36_001020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBF0872908.1"
                     /translation="MEKFSVVIAGGGSTYTPEIILMLLDNLDRLPLRAIKLYDNDEER
                     QNKVAKACEILIKEKDPNIEYLATTCPKEAYTDVDFCLAHIRVGKLEMRELDEKIPLK
                     HGVVGQETCGPGGIAYGMRSIEGVLENIDYMEKYSPNCWMLNYSNPASIIAEAVRRLR
                     PNSRVINICDMPIGMEHNIARIAGLKSRKHMDIRYFGLNHFGWYTSIKDKKGNELLPK
                     LVEHIKEYGFINGEEGMKNDKKDSWFETNLFTKEIVKTDLTTIPSSYLKYYLFPDYVV
                     NHSDVNYTRANEVIDGREKEVFGSCALIEKQGHSKGSGLKIGIHAEFIVDLATALAFN
                     TQERMLLIVQNNGAIENIQDDAMVEIPCIVGKDGYEPLSIGKIPTFQKGLIEQQLAVE
                     KLVVDAWIEKSYNKLWQALMLSKTVPSATVAKELLDDLIEANKNYWPKLN"
     gene            complement(30251..30580)
                     /locus_tag="KNP36_001021"
     CDS             complement(30251..30580)
                     /locus_tag="KNP36_001021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBF0872909.1"
                     /translation="MVPEMEEKVFSIISEAGDAKSDVMMSLKEIKKGDYNKAKHLLNS
                     ASEKIQTASKHHLELLSNAMNSEDSGTDFLVVHSEDHYSNALFAHSLVSELVDIFEMM
                     DPRINKN"
     gene            complement(30604..31893)
                     /locus_tag="KNP36_001022"
     CDS             complement(30604..31893)
                     /locus_tag="KNP36_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0872910.1"
                     /translation="MEALQNNLRRFLLPIAQKIEKQRHLQAIKEGMISITPIIIVGSL
                     SMLFMALNNMLPEGSAKTLLSENMDTLLIPNKFTMSLLSIYSAFFIAQALAKKYNLNH
                     VEIGMTAVVAQLVVCGQVVDGVLDTSYLDAQGLFVSILVALLVVDITKFMNDKNLVIR
                     FPKEVPSVVNKSFRNLTPMIVCIMLFTAIAAITKNVSGQPLPAIIMNFLAPAISSVDN
                     VFAVTIILFITQLLWFFGLHGAAITSSIWMPIAATYMAENATLIAAGGDPKYVFTIGF
                     YYGFLQVTGSGITLGLVYLMSRSKCKSFNSMGKVVILPSLFGINEPVIFGTPIVMNPY
                     MFVPFVFGPVLVGALNFMALKVGLVGLPIAEPPGFLPPGVAAFLMTLDWKAIVLVFAS
                     IILMTLIYYPFFKIMEKEELNKNAELATTLDDDSFDF"
     gene            complement(31909..32235)
                     /locus_tag="KNP36_001023"
     CDS             complement(31909..32235)
                     /locus_tag="KNP36_001023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872911.1"
                     /translation="MNILLVCANGASTGVLVEKMKSFCSEHEKLKTKTINIEATSFEN
                     LKSYIEANDTDVVLVAPQIRFKEDDVVEACKNYKIAVGLIDTKHYGRMDAPSVMKSAI
                     ELYKNR"
     gene            complement(32370..32999)
                     /locus_tag="KNP36_001024"
     CDS             complement(32370..32999)
                     /locus_tag="KNP36_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872912.1"
                     /translation="MQDKILRDKKANDPWARMTTRNGFSADEIISSFQKAIRRNMVEE
                     ACEFAYELYISSPELEDKLWRRILTISVEDIGMGDPSAVIIINNLNQVRKEYSYADGD
                     RPLFFIHAIRYLCACEKDRSSDLLKNIIIKGFAMGKVPEVMDVALDKHTYRGLEMGRD
                     SFHFLNEASIVIPEKEVDNDYKERYLKILEKYKQEEVIDTAFKFNHWQY"
     gene            complement(33214..35871)
                     /locus_tag="KNP36_001025"
     CDS             complement(33214..35871)
                     /locus_tag="KNP36_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0872913.1"
                     /translation="MIYKKDKVMKVLESSYRENEKGITANQLSEKTGIARNNISTYLN
                     QLFNEGMVTKIKGRPVYYIPANLNLNKNELLDTQSELLGIKKGTKVENKIKKDSFETL
                     IGKEHSLRPIIEKCKVAMLYPTNGLHTIIYGETGVGKSMIARYMYDYSIDSGIRKNKA
                     PFVTFNCADYANNAQLLMGHIFGVEQGAYTGAESSRKGLLEIANGGILFLDEIHRLPA
                     EGQEMLFTFIDKGTFKRLGDATKERESKVLIICATTENPTSTLLDTFNRRIPMKIEIP
                     SLRDRTMIERMELVKNFFKEESKSISISIKVHKEIIKSLLLYDCKNNVGQLQNDIKLA
                     VANGYLRYKRDNKEPVYIEKKYFDKSINEVSDDYREKSIKADEVITHGIEYFVFTSLG
                     EEEVINYNDINIINAVNTNLNKSVEMNIADASLFNNVKFKSMCESIRQIIKEDEEIDI
                     SESIFKSMAIYIKSVLDKSSSTNNIDLNQIRRNNRSEFKTALKIVGIIENEFDLFLSI
                     ETVAYITLFIVQAKQDEQNKIVNNINIIVAMHGETTASSMVKAVGDIIGKCSAISFDM
                     KLDKSYDEVIVDFKNLINNIDNKDVLLFTDMGSLNSFDEIIKKEKKCGVRVIPMVTTL
                     TVLEAVQKANMGLPLNDVYNSITNTRKYYFGTNEIQNKENLSKTIIIASHVSEGVDNK
                     TRKILEEKMSRYLDGIDIISVPYKTEKDLSLNITKLKESSNIVAVINEQRINIRGIDY
                     ISKKDIDKDENINKLKNIIKISIGYDDVVEGLKTSLKSSNYNRIFKDIKYVSDELFLV
                     FNIEKKYDKVIGLMMHLAFMVDGLIGNTREIEKLDKEKTLDYHKSLSKIKDIVSQLDK
                     KYNIEINEKECYQILLILEYAEIIEKDYQ"
     gene            complement(36230..37174)
                     /locus_tag="KNP36_001026"
     CDS             complement(36230..37174)
                     /locus_tag="KNP36_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009524518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872914.1"
                     /translation="MNREKILEIKNLKQYFHLDKSTTVKAVDDISFDIYKGEIFGLVG
                     ESGSGKSTTGKTIIRLHESTGGEVIYKGNCISDKKTYKFIKKDVNKSMQIIFQDSTSS
                     LNPRMTIADIISEPLKIQGICKNKTDRMNKVYEMLKLVGLDRSYANKYPSDFSGGQRQ
                     RIGIARALSVDPEFIIADEPIASLDVSIQAQIVNLFKKLQQEKNLTCLFIAHDLSMVR
                     HISDRIGVMYNGKLVELADSNELYNNPIHPYTKSLLSAIPVPDPRYAKSRNRIEYNSN
                     GYDCSNEKSLSWIDVSDGHFVYSSKSEINKYQQNLKVV"
     gene            complement(37167..38192)
                     /locus_tag="KNP36_001027"
     CDS             complement(37167..38192)
                     /locus_tag="KNP36_001027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0872915.1"
                     /translation="MEHLLEVNNLSVSFKVEEGEVQAVRNVSFNLKKGETLAIVGESG
                     CGKSVLCKSLMRILPYNGYIKNGEVLLKSSDLVKKSEKEMEDIRGKNISMIFQDPMTS
                     LNPTISIGKQIAEAVIIHQGISKSEAKKRAIELIELVGIDNPEKRFKQFPHHFSGGMR
                     QRIVIAIALACNPDVLIADEPTTALDVTIQAQIIDLIKDLQHKIGLSIIFITHDLGVV
                     ATIADRIAVMYAGKIVEIGTVEDIFYDPRHPYTWGLLGSLPTLDSQDDYLYNIPGMPP
                     NLLNPPKGDAFAIRNKNALKIDYEKEPPMFKINDTHSAATWLLHPDAPEVDVPVRVNC
                     GRVISNE"
     gene            complement(38267..39835)
                     /locus_tag="KNP36_001028"
     CDS             complement(38267..39835)
                     /locus_tag="KNP36_001028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0872916.1"
                     /translation="MKLKKLKVLSLVMILSLMAGCSSGGDKDKKADTPKDGKVLVYGS
                     NDYTSINPALYEHGEINSLIFNGLTAHDENNKVVPCLAKDWKFDEATNTYTFNLRDDV
                     KWHDGEKFTANDVKFTIETIMNPDNASEIASNYEDITKIDVVNDNTIKITLKAPNTAM
                     LDYLTVGVLPKHALEGKDIATDEFNQKPIGTGPFKLEKWDKGQSITLVKNSDYFVKEP
                     GLDKVVFKIVPDDKAKAMQLKSGELDLAQITPKDMSNFEKDEKNFKVNIMKTADYRGI
                     LYNFNSKFFKDKKAKGLPNALSYAIDRKAIVDSVLLGHGVPAYSPLQMGPYNNPDIEK
                     FEYNPEKAKQEIEKLGWKLGSDGIYEKEGTKLAFEITAGESDQVRVDMAKICAQQLKE
                     IGVDAKAVVVTETDWANQDAHLIGWGSPFDPDDHTYKVFGTDKGANYSAYSNPTIDKI
                     LQKARETEDKDEKLKLYKQFQVEMTKDMPYTFIAYIDAIYVGKPNIKGLTPDTVLGHH
                     GVGIFWNIADWTIE"
     gene            complement(39948..40859)
                     /locus_tag="KNP36_001029"
     CDS             complement(39948..40859)
                     /locus_tag="KNP36_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872917.1"
                     /translation="MKPQYSDFEIVGENYILVAEDEHIETKKTLSKKIKELPYISIII
                     LSIIVIGSVFSSFIMTHEPTYMDLASSNLAPNKTFLFGTDSMGRDIYSMIWYGGKISL
                     FIGLFSTVISTVIGIVYGSISGSASELVDDAMMRFTEIILSIPSILIIIFVQAILGNS
                     NPVSMSIVIGITSWMNISKIVRTEVRQIKNSEYILAAKSMGGGFFYVLKQHLLPNFVA
                     SIMFMVVTNIGAAIGTESTLSFLGIGLPIEIVSWGSMLSLSEEALLSNRWWIILIPGI
                     FLVTTLVCITNIGNYIRKNNNKKSSNL"
     gene            complement(40843..41829)
                     /locus_tag="KNP36_001030"
     CDS             complement(40843..41829)
                     /locus_tag="KNP36_001030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0872918.1"
                     /translation="MLKDILKKLLQFILVMFLLSFIVFYMARLAPGDPLISYYGDGVE
                     RMSTQEKENAMKKLGLDEPIYSQYIKWISNASKGEFGISFKYKQNVTSVINDVYINTI
                     ILGGSGYILTFVLALLLGIFCTLHEDKLIDRIICKLGTITNCIPSFWVALVLILIFSI
                     NLSILPSSGAYSMGEESSILSRISHLILPLTVLILSHLWYYTYMIRNKLLEEIREDYV
                     LLCKAKGLNNRTIVFKHCLRNIMPSYISIMAISIPHILGGTYVVEKVFSYPGLGTLCF
                     ESAKYHDYNMLLVLCLITGALVVFGNMLAQIINNKIDPRMKYDRGDTNEATI"
     gene            42189..42590
                     /locus_tag="KNP36_001031"
     CDS             42189..42590
                     /locus_tag="KNP36_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBF0872919.1"
                     /translation="MLLKELYSKTMYTVEENFKENGLTHQQIIVIKLIAHNQELTISQ
                     LCDEMSLAKGTVSGIISRLEQIGYIEKFKKSNDKRNTYVKFTTTGFEFATNFKIKMQE
                     SFDDIFKNCDENELSDLVKNLRNILAKVKER"
     gene            42593..42991
                     /locus_tag="KNP36_001032"
     CDS             42593..42991
                     /locus_tag="KNP36_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03987 family protein"
                     /protein_id="HBF0872920.1"
                     /translation="MNYKLILAIVFITSALIFYTIGVFGERKAKILKKKHVIIFWLGF
                     IFDTLGTFTMSNIANSHTFEVKSALSQNLHSITGLLAIVLMLFHASWATFVLYKDDEE
                     KKKFFHKFSIVVWTIWLVPYFIGMFIGMAG"
     gene            complement(43441..43665)
                     /locus_tag="KNP36_001033"
     CDS             complement(43441..43665)
                     /locus_tag="KNP36_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NifU family protein"
                     /protein_id="HBF0872921.1"
                     /translation="MREKVEKVLEEKIKPVLQRDGGDVELIDVNENGVVLVRLQGACS
                     GCPGVTMTIKAIIENVLVSEVPGVTQVLGV"
     gene            complement(43700..45067)
                     /locus_tag="KNP36_001034"
     CDS             complement(43700..45067)
                     /locus_tag="KNP36_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0872922.1"
                     /translation="MKEYIINNVEEIREELIDLSKKIWENPELAFEEKYASSIQKEYL
                     KSKGFKIEEVENLPTGFIASFGEGKPVIGILGEYDALPELSQCVSAERKPLVEGKAGH
                     GCGHNLLGVAGVGAVVSIKKLIEENKFNGTIKYFGCPAEEEGGGKTVMCINGCFDDVD
                     CAFTWHPFDINAPWRGGSLANLSVKFKFKGITAHAAQAPHNGRSALDAVEIMNVGANY
                     LREHVIDSIRMHYVITNGGGRPNVVPGFAESWYFIRGKKAKDAEHVLDRLIKVAQGAA
                     MMTETEMEYKVTDGIYDYIPNQCLTDLVYDNMVFVGCPKNTPEEEEFAKKLCDTLTRE
                     ERLGVATSLQNDKSIVESYIHKEIVDGDKDKGLAGSTDVGDVSYVIPVAQFAMAAWPV
                     GIASHTWQSCSSAGSNIGFSAMINSAKVLACSAYDVFMDTKIIDEAKIEFDKSLDGQK
                     FKPLV"
     gene            complement(45151..46686)
                     /locus_tag="KNP36_001035"
     CDS             complement(45151..46686)
                     /locus_tag="KNP36_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872923.1"
                     /translation="MLNNLSNININENNLIKNQYSISLLKECLNCKVIDEREVYNIQQ
                     EVSLILMDLIKKYTNGQSTSVKTEVAEKLLISIWYAIDAYINKLGDIEKRVVELTAKN
                     VKKVYLGGIEILEEELVRLKDFYKLMMSRKLDTNSIAYNDTLMELSSFFKSYIVKFEA
                     QDVPVSIDYPLALDDMDVKGIYYVKNYIESIDIENRFCNLFKKKDREKLFYDYGMTYK
                     IDCDVILVNLFELIMNNCIFSTILGNEVTNLEISKYEYEFLEKQFKNMYNNITEDKVI
                     DSEESNIIELIEVDDSFNTEVDSNLDYNDFEEINREIRINKKITLLLMEAIEVLIKRL
                     SIEDEDVIRYIKKYEKIFIESVLSSIKSNTFKSMVTVSKNKKEHLEDYIVDDESKLDD
                     ESFREIFNEILDSTSIIEKIRIIKENINAKKDFIDILESECLFGEEYLMLFASLSELE
                     LAILGSVVFYEDIRMREINILEFMLNEKTETTLWKIEYIKFMKRQSEDKIYSIEEHMN
                     KIN"
     gene            complement(46709..47143)
                     /locus_tag="KNP36_001036"
     CDS             complement(46709..47143)
                     /locus_tag="KNP36_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872924.1"
                     /translation="MISPIILSSINQNLKEIERNELLETNIESGDYGLALSESDVKDI
                     INSRDNTLKGYGRIELDIKVTKQLIENIYTSQYTNVDNYLEAINDMQEIFYYLKNETD
                     DKICDDEIIEILGEFYEKFSGNMDNVRGEADEFAKKFKFGEV"
     gene            complement(47403..48314)
                     /locus_tag="KNP36_001037"
     CDS             complement(47403..48314)
                     /locus_tag="KNP36_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="HBF0872925.1"
                     /translation="MNKKIELIGNFASDWIRYSDYEYKITEEDELYIVPTEDAVFTMY
                     NPFDVADDIIVDIIRIGQEALQDISKETKEMKLKKEVLEFVKKYGLLGLIYSSVYNRD
                     IVGEERVLMIEKNYITKENILSTDEYVNMFIPFASDEDVYFKKYRRGIDVSKREESPK
                     FFGKRPLILDLVFSKFYTEQLDWIVSFAKDMCKHFNQICVYKNTSNLLTESVTIMSGG
                     FNPQKIGFSISQLDKPIIAWEFDSLKTAIETIYAFAITSEPSSLNKCKYCGKIYIPTN
                     SKSQYCSPSCRNCSNVKKSRSRAKKDK"
     gene            48610..48963
                     /locus_tag="KNP36_001038"
     CDS             48610..48963
                     /locus_tag="KNP36_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HBF0872926.1"
                     /translation="MDRKRELKQLYKEMKFDTGVFIIKNDITKKIYLGKSNDIKSKFN
                     SLKFQLGAGSCMIKELNNEWKKYGEKAFTFEVLELIKHDDNKTEKDYLEELDILEMVW
                     LEKLKEDNTYEIYSI"
     gene            complement(49182..50123)
                     /locus_tag="KNP36_001039"
     CDS             complement(49182..50123)
                     /locus_tag="KNP36_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp25"
                     /protein_id="HBF0872927.1"
                     /translation="MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAG
                     LISDKQDFTTAVLINADSTMVDGIAASGLAGVNNAAILLTNKDDIPEATLQRLNRVTK
                     IYVIGGENSISKDVEKMLLMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNG
                     FKDEADAVSVASVAYRDGAPIILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSD
                     YIVSRYRATRIGGVDRYQTNKNVIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVV
                     LVSNKSDKSILSGASKVTAIGISDKSIIEQCLDAVKK"
     gene            complement(50224..51459)
                     /locus_tag="KNP36_001040"
     CDS             complement(50224..51459)
                     /locus_tag="KNP36_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HBF0872928.1"
                     /translation="MKILHIITQKPNSTGSGIYLSGMIKGFEKIGHKQAVIAGIDVND
                     DVNCFPSEVSFYPVKYNCGELNFPVVGMSDSMPYESTRYKDLNIDMINRLKYQFKVNI
                     DKAMNDFKPELIICHHLYLLTAFVREMVKDIKVMSICHGTCLRQLNTIDLEKEYIIAN
                     IRKLDLIFALHENQKYDIIKTFGVSESKVVVIGSGYNDDIFYNKNYKIKDDKIKIVFA
                     GKICKSKGLIPFIKAISKLKYSKDLIEVNFAGTGSDIESYNEIVKLASKSPFKMNFLG
                     KLEQRDLAELFNRSQIFVLPSFYEGLPVVVLEALSCGTDVITTDILGVKEWIGSEINN
                     SGKIEYVSLPFMEKEGIPKDEELYDFENNLYNAIDSKIQSLLNNSNKKTSVDMSKKTW
                     DGLAYRINEVILMDELCLV"
     gene            complement(51503..52357)
                     /locus_tag="KNP36_001041"
     CDS             complement(51503..52357)
                     /locus_tag="KNP36_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872929.1"
                     /translation="MALNIRNYSLLCNQGTAKFNEDVVGINPFGAWVLDGATGLNGKN
                     LVSTESDARWYVQWWNRYLYKNINKEESLKSIINTGIIEVKKEYELRLNGFKVEKLDL
                     PSSSIVVVKFHENKVEYFLLGDCALFIKNGDSKVIKDRSICKFDNTVFDEMSKLSNLE
                     EMAFDEIRTSVMDTIVSNRLKKNTKEGYWILDFDEEAVENSIYGYIEIKKDFQLMLTS
                     DGFTSACDRYNLIKEEELIRIAEKFGIGYIHNKVRDFEDNDYKAVKVPRFKVKDDSSC
                     LYLDIYND"
     gene            complement(52485..53660)
                     /locus_tag="KNP36_001042"
     CDS             complement(52485..53660)
                     /locus_tag="KNP36_001042"
                     /EC_number="2.1.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolecarboxamide
                     formyltransferase"
                     /protein_id="HBF0872930.1"
                     /translation="MARELELKYGCNPNQKPSKIYMKNGELPIEVLNGKPGYINFLDA
                     FNSWQLVKELKEATGLPAATSFKHVSPAGAAVGVPLSDTLKQIYFVDDLELSPLACAY
                     AMARGADRMSSYGDFIALSDVCDKETATIIAREVSDGIIAPGYTDEALEILKGKRKGN
                     YNIVKIDENYTPEPIETKDVYGITFEQGRNEILINEDLLKDIPTDNKIFTDSAKRDLI
                     IALITLKYTQSNSVCYAKDGQVIGVGAGQQSRIHCTRLAGNKADTWYLRQHPKVLNLK
                     FKKDIGRPDRDNTIDVYLSDDYMDVLADGIWQNFFEEKPEPLTGEGKRAWLKTLTGVA
                     LGSDAFFPFGDNIERAKRSGVSFIAQPGGSIRDDNVILTCNKYNIVMAFTKNRLFHH"
     gene            complement(53759..54643)
                     /locus_tag="KNP36_001043"
     CDS             complement(53759..54643)
                     /locus_tag="KNP36_001043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="HBF0872931.1"
                     /translation="MKFVTFCSSNEEKIGVFNSETNSIYEINSLGLSKLYTDMNDFIE
                     NVSTGDLEKIKNNSFENAKCYKLEEVKLCSPIVRPKKDIICLGLNYKDHVNEIPDGVI
                     KNVVMPDYPIYFSKRADKIIGVDDKISLHGDLVEKLDYESELAVIIGKEGINISKEDA
                     YEYIFGYTIVNDISERALQDKHVQWFRGKSLDTHTSMGPCIVHKEEFEHPLKLDISSV
                     VNGEVRQDSNTEYFIFDIPTIINDLSRGMTLKPGDIISTGTPAGVAMGMNPQVYLKHG
                     DIVECKVEGIGVLKNIVD"
BASE COUNT        17899 a         9472 c         5889 g        21442 t
ORIGIN      
        1 ttttaattga taaaataaat tctcttttca ttccatataa ctttgatata cacaaaccat
       61 agtgtatttt tttaatataa gcataataaa agcagtcaat cataatgacc aactgctggt
      121 gatactggat attaaattat taacttagga tttaataata tatagatttt tcaatattgg
      181 gtaacaatgt atatatagac ttgttgatta ttttctcgaa atattcttta tactcataag
      241 tcttattcca tcgttcaact gaaaatggat atattccata tcttcgtgtt gtatcaacaa
      301 atcttttttc taaaatacaa aacccatttg catctgctaa tgcatcacaa agaataatca
      361 acttatcata atcgttatat tcaaggttgt ttaaatagtg attgataaaa tcatactgtt
      421 ctttactaat atctttattt ccaatatcag cttctatatc cttaacagga aaagaatgtg
      481 tcaaacatac cctcgccact tcatcccatc ccttagaaat aacataatca tatccatcaa
      541 taatatgcct tacagaagaa ataccagttc ttcttccaat gtcatgtaat aatccacata
      601 caaaggcctt ttcactattc aaattttcac attgctctgc aatcaattta gctacattag
      661 caacattgta agaatgtttt atccatggac cgggattcat tttgccagcc acttctaact
      721 cttctattgc aatttcttta tttggataca tattagtttt cctcctcaag tttaaattaa
      781 ttattatttt ctacttaata attcaaaaaa atagtgataa aatggtataa aaaataaaga
      841 gaaactttat aaaagcttct cttttttcat ctcttccata ggtatcgttt tccaatgttc
      901 tctcaaaatt ctttcaacat tttctaaatc attctccctc atagatttta ctacttcaat
      961 atgttgatta ttgctgtatg tcaacatttt atataactca tcttcattat cactagtata
     1021 tgactttgac ataaaattat atcttaaaga gttcaataga tttactaaca cctgattatc
     1081 tgatttagtt atgtatatat cgtgaaattc attacttaat tttaaatagc tattgtaatt
     1141 tttatacttt atagagaccg ccatcatttc tgttaattct tccattttta ctaggtctga
     1201 ttcagttaaa ttttgtaatg ctgaagaacc ggctaacgca tccaatactc caattacgga
     1261 ataggtgtct aatttctcct tttcctgaaa ttcttttact acaaatccct tattaggtat
     1321 tttttctagt aaattttcac ctgctaacct agttaatgct tctctcgctg gtgttctact
     1381 aactccgata gatttacaaa tctcagattc agtaattctc tgattagctt catattctcc
     1441 attttggatt ttctttgata tatagtcata tacttgagtt gtaagtggat ctaccttcat
     1501 aagacgttcc tccatattaa gattataaaa gttaaatctc cctacaactt tggtagagag
     1561 ttcagtttta tcttactaat ttatataata tcacaattat gatatttttt atacttcttt
     1621 gtaatatttt gaaatactaa aattcttatg ataatttata caaaaaaagt agaaaaagtt
     1681 ttgataaaac aaaactcttt ccacattcac cttattttct atttattttt ctaaaaaaag
     1741 atatttaatt tactctaaaa attctaaatg atttagagtc taaatctact ttcaactcat
     1801 tattttcaat ttgtatagta ctatttgcat ttttaagact atactttata ggtatttcct
     1861 caataaaact actctctata cataatgata tactttccac attttcactt ctatttacta
     1921 aaattaacat tctatcatta ttttcattaa ctctaataaa agaaaataca gaatcattat
     1981 tagtatatat aaattctgta tttccagaac ttaaaagttt attcttattt ctaattctta
     2041 taacatctct ataaaaatta agcatatctt cgtcttcatt tttccatgga taagttcttc
     2101 tattatctgg gtcaacacct ccacaaagac ctgcttcatc tccataatat atatatggta
     2161 ctccttcaaa tgtcatctgt atagctacag caagcttcac taaatctaca tcatcattta
     2221 attccgtttt agctcttgta acatcatgtg ttccaattaa atttaaatta gacctaaatg
     2281 attcttttgg ataattttct ttaatctgca tatatctatt acaaagttca tatgaattaa
     2341 tttctccttt taagaaagaa aacatgttat ttctaaaagg ataacccata acagaatcta
     2401 attcttcacc taataaataa cttcttctct gaccatagct aatcttattt gatgcatctt
     2461 cccatacttc acctataaga attgagtcat catctgcctt ttttaattcc ttttttaact
     2521 ctcttataaa cttagttggt aattcgtctg caacatctag tctccagccc ttaataccca
     2581 tatttaccca tttatttata acgctatcat tgtcatatat tatataatcc atatagctat
     2641 gttctaattc atttatattt ggcaatgtct taacatccca ccaactttta tatttttgag
     2701 gaaattcttc aaacatatac catgaataat atggagattc tttagattga tatgccccta
     2761 aactattata gtttccatac atattaaaat atttactatc tgctccagta tgactaaaaa
     2821 ctccatctaa tactattgat ataccttttt cttttgcttt atcaataagt tctttaaatg
     2881 tatcttcatc cccaaacatt gggtcaattt ttttatagtc acctgtatca tacttatgat
     2941 tactagaggc ttcaaatata gggcttagat atagtatact tacacctaat ttttttaaat
     3001 atccaagttt attgattatc cctcttaaat ttccaccatg gaaatcccat cttataacat
     3061 ccccttgact atcctttatg tacataggtg tatcttccca atttccatat atgaaactat
     3121 tttttttagg attatcaacc ttaccactac gatttccatt attgaatcta tctacaaata
     3181 tatgataaag tattccttct ttgtaccatg ttggtacttt aaaatctttg taaacagtga
     3241 tttgatattt attaatatca ctataattat attcacaaga atatccatta tctctgtttt
     3301 ttccataaaa taaagtcttt atctgaccat ccatttcaac atcaacttta aagtaataaa
     3361 aataaacacc tgtaccatca aacttttcaa tcttaccaca aaagcacttt ccaagtttat
     3421 cattatctaa ttcttcattt aaagttattg ttctcatttc ttcttctcta tttatttcta
     3481 gggaaataga cttgatattg tatccctcat ttactttaac acaaatggtc aattcctcat
     3541 caaattttaa agctccaaac ggagccttaa aatttttatc ccaagagtta tattctatta
     3601 cactttgcat ttaatcacac ccttttaaac caaatgtctt ttgcatactc agaaattgtt
     3661 ctatcagaag aaaaaaatcc agaattagct atattaacta aagacatttt attccatttt
     3721 tctttatctc tatataacct gtttatatct gcttgagctt gaccataatt ttcaaaatct
     3781 ctcaatacaa aatactcatc attgtaagta gtgagtgaat tataaatact tcttccttct
     3841 tcgccaagat taggaataaa tccatttatt aaatcatcta ctaccctttt tatatccata
     3901 ttagaatgat ataggtcaag tgaagaatat ccaccatatt tattataatt tagtacttgt
     3961 tctgcactaa gtccaaataa aaacatattt tctttaccaa cctgttcaca tatctctaca
     4021 tttgcaccgt caagtgtagc caaagttata gcaccattca tcataaactt catattactt
     4081 gttccagatg cttccttagt tgtagttgaa atttgctcac taacatttgc tgctggtatt
     4141 attatttctg ctaatgatac tccataattc tctaaaaata ctacttttaa cttgtccttt
     4201 actctaacat cattatttat agtacttgca acagaattta taaatttaat tatacattta
     4261 gccaaataat atcctggtgc tgcttttgcg ccaaatataa aagttcttgg gtcaagattc
     4321 aaattaggat tatcaagtaa ttcatgatac atatgaagta cattaaatat attcagtaac
     4381 tgtcttttat acgcatgcaa tctcttaact tgaacatcaa atatcgaact tgggtctaca
     4441 tttaaatcgt atttatcttt tataaacttt gctagatttg ctttattatt gtattttata
     4501 tcatcaagtc tttgtaaaac agaggaatca tttttaaatt tttcaatatt ttttaattgt
     4561 aatgtatctt tcttccatga atcaccaatt aaatctgtaa ttaaattgct aagttgagga
     4621 tttgaactta taagccatcg cctatgtgca attccattag tcttattatt aaatttattt
     4681 ggttcatctt gatagaaatc ttttaatacc tctgtttcaa gaatatgagt atgaagctta
     4741 gcaactccat ttacactatg acttgtgaca atacataagt ttgccatatt gatattgtca
     4801 cagtctatta tactcattct ttttattcta tcttggtcat atcctttatt atttaattcc
     4861 tctacatatc ttctatttat ttcttctatt atcatataaa ttcttggtaa tagttctttc
     4921 atcatactta caggccattt ttccattgct tctgacatta tagtatgatt agtataggac
     4981 actgtttttt tagttatttc ccatgcttca tcccaagata aattttcttc atcaagcaaa
     5041 actctcataa gttctggtat gcataaggta ggatgtgtat catttatatg aattgctacc
     5101 ttatcgaata aattattaat atttaatttg ttctttttat attttcttat tatatcttgt
     5161 atccctgcac ttacaaaaaa gtattcttgt ttcaacctca acaacttacc tgcatagttt
     5221 gaatcatcag gatataatac ctgtgatatt tcctcagtat aatacttatg ttttaaagcc
     5281 tcttcatagc taccagaata atttagagca tttgaggtaa gttcaccaaa atctctcttt
     5341 ggtatttcac tcttaaacaa tcttaaagta tttatacatt ggttttggta tccgattatt
     5401 ggtatatcat aaggcattgc cattacagga aggtagtttt tatgaattac ttttaaatga
     5461 ctaccttcct tgattaattc tacctcacca ccaaacttca ccattgttgc ttcatttggt
     5521 cttacagttt cccatgcata tcgtccttct gtaagccagt tatcaggcac ttctacctga
     5581 taaccattta caaatttttg ttcaaacaga ccatatttat accttattcc atatccttga
     5641 ccacttatgt tcaaagatgc catagaatct aaaaagcaag ctgctaatct accaagtcca
     5701 ccatttccta aggctgggtc tacttcagct tcaattaaat catccaagtt gattcctaat
     5761 tcagataaac cttctctaac ttcttcttca atatttaaat ttaataaatt agattttaac
     5821 tgtctcccta ttaaaaattc taaactaaaa taataaactt cttttttctt atctaacttt
     5881 gtagcaaccc atttttttgc tatctcatct ttcaatagac tacataatac atttaacaat
     5941 tgttcatcag tagcttcctt gatagattgt gcatataagc tatacatttt tacttcaaat
     6001 ttttgcttga atttcttttt gcttattgtt accaaaaaaa ccactccttt aatcacatat
     6061 gtctctatat gtttctatat actccttagc tgattttttc caactattat ctgttttcat
     6121 tgcattttca actaatttaa tccatttttc tttgtcctta aatactttga ttgcattttt
     6181 caaacagaaa aacatctcat gagcattgta atttttaaaa ctaaatccat tgccttctcc
     6241 agtaaattta ttataaggtg ttactgtatc tctaagccct ccagtctctc taactattgg
     6301 taaagaacca tatctcatag ctaacatttg acctatacca caaggctcaa ataatgatgg
     6361 cattaagaac atatcacttg cagcatatat ctgttgagcc aatgatgcat taaaagtaat
     6421 tctagctgat actttatctg aaaaattaga atcgtaatag ttgaacattg attgatattg
     6481 atgttctcca gttcctaaaa cgacaatctg taaatcttct ctcataagtt ctggcatcat
     6541 gtatgctatt aaatcaaatc ctttttgaga aactaatctc gaaactatac ctatcaacgg
     6601 aatagatgaa tcttttttta gtcccaatat atcttgtaat ctcaatttat tttctacttt
     6661 tttgtcaatt gagtctacat cataatgaac aaatatatct ttatcttttg cagggtcatt
     6721 taaatcataa tctataccat ttaatatacc ttttaatttt cctgactctt ttctaagtaa
     6781 tccatctaat tgttcgccat aaaaagatgt ttgtatttca tttgcataag taggactaac
     6841 agttataatt ttatctgcaa aatttatacc agctttcata aaatttattg agccataata
     6901 ctctatatct ccattatcaa agtatttttg tggtaagtcc aatatatcat ataaaacatg
     6961 cttatcaaat acaccttgat attggagatt atgtatagta tacatagttt ttatattttt
     7021 atacccctca agggttgcat atctttcttt tagaattaat ggtaacatcc ctgtatgcca
     7081 atcatttata tgtattacat ctggataaaa atcaattcta cttatagctt ctaaaactgc
     7141 atctgtaaag aaagtatatc tttctgcatc atctccatat ccatagatac tctttctttc
     7201 atcttctctt ctaaaataaa attcattatc tataaagtaa aattttacac catccaattc
     7261 catttctaaa agaccacagt attgatttct ccatccaaca cgtacactaa acacagctat
     7321 ttcttttagt tgatctttta aataacttgg tatagttgaa tatttgggca ttattaccct
     7381 tacatctaca ccttcttttt ttaattcttt aggcaatgca taagaaacat ctcctaatcc
     7441 tccagttttt gcaaagggcc aacactctgc tgttacataa aaaaccttca ttagtcattc
     7501 ccccttctaa aaaatttatt tatatatttg tattcttttc cactacaaga ggatattttt
     7561 catctcctct taattctttc ccatttgata cacttgtatt tttatctaat attgcattat
     7621 atagttttgc atttgacttt attacacaat tttgcattac tattgagttc tctataactg
     7681 ttcctttttc aacatttacc tttctaaata tgatactatc ttttacagta ccttctatta
     7741 aacaaccaga tgctataaag ctattttcta ctttagcact atctgtataa attgtaggtg
     7801 attcattctt ttcttttgta aatatctttc tttcagaata taataattca tctgcaactt
     7861 ctaaatttaa taaatctttg ctcatttcaa aatatgattc aacagaattt acacatttta
     7921 gatatcctgt atattcatag gctcctattt tcatgttttc tgcttcttca ataataaatt
     7981 cttctaaata acaataattg cctttattta caatgttata tatacattca acaaaatctt
     8041 cacgcttcat aatatatgtc tccatacata tgtttgctct agggaactta cctaaattat
     8101 ttcctacatt tattacccta ttgttactat ctaaatttag agttaagtta ccagcaaaat
     8161 ctttatttgc attatttaca tttttatata ttatagttat atcattatga gattttttat
     8221 ggtattccaa tgcttgagaa taatttaaat tgcatagcat atagcttgga gctattaaaa
     8281 tatattcttc ttcactcttt tctatataat ctagattagc taagatagta tatatatcac
     8341 cttctctatg tgagtaagta tttctatact tagtgttttc tggactaaaa attgataggc
     8401 cacctttttt tctacttaaa tcccaatctt taccactacc tatatggtct gttaatgatc
     8461 tgtatttttc ttttgcgaat attccaactt tagtgattcc tgaatttatc atattagata
     8521 aagcaaagtc tattattcta tatcttccag ctattggtgt agatgctatt ggtcttccat
     8581 agttaagttt gtttattgct gggtctcctt ttttgtttaa atttattatc cctaaacatt
     8641 catttctcat cttaaagacc tccttctatt aatacgcatc taggttcgat attttcatac
     8701 tcagaaacta catttatttc attatttaca ttctttatct gaacattatc atttatagtt
     8761 gcacactcac ctatcatagc tttttctata gttacatttt cacctattac aacatttggc
     8821 attattactg aatcaattac tttacttcct ttaccaacaa caactccatg tgataataca
     8881 gagttaccta cttcacctaa aattctacaa ccatcagcta tcattgatct atgaacattt
     8941 gcatttttac ctatatattg tggaggcatt gccatagtat ttgtatatat cttccactta
     9001 gggtctgcta aatcaagtgt ttctggagat tttattatat ccatattagc atcccataga
     9061 ctttgtatag ttcctacatc tctccagtat cctttaaatg gataagcata cattccaaca
     9121 ttatcttcta acattttagg tattaaattt tttccaaaat catcataatt tatttctgga
     9181 tttttttctg cttccttaaa ataatttctc aacattttcc aatcaaatat gtatactccc
     9241 atagatgcca aattgctctt aggttcactt ggtttttctt caaattcata gatacttgaa
     9301 tcttcatttg tattcattat cccaaatctt gaagcttcat cccaaggaac ttcaatcact
     9361 gctattgtag ctttagagcc tttttcctta tgaaatttta acattttgct ataatccatc
     9421 ttgtatatat ggtcaccaga taatatcaat acatattctg gattataggt atctacaaag
     9481 tccatatttt gatatatcgc atgtgctgta ccattatacc aatttccttc tttttcattc
     9541 ataaatggtt gtaaaacata gacaccacca tttattctgt ccaaatccca atgacttccc
     9601 atgcctatat gtgaatttaa tatcaacggt ctatattgag ttaaaacacc tacagtatca
     9661 ataccagagt ttgaacaatt gcttaacaca aaatctataa ttctatactt acctccaaat
     9721 gatacagctg gtttggcaat tctttttgta aaaacaccta atcttgaacc ttgccctcct
     9781 gccaaaatca tagctaacat ctcttttttc atttaatgac actcccctca tctagtaatt
     9841 aatatttata attgcatttt tacttttata aactttatca gtcaataaat gtcgtgtata
     9901 aatgttgctt aaataatacc ttaataaaaa taaaataata tcaactatac aattgatata
     9961 atgtataccc cataatggac ttaccgacgt atacattatt ttccataagc actatagtat
    10021 ttattaatat tcaattatcg gttaaaaaat aatacaaatt ttattttata aatataaaaa
    10081 cattttttat aaatcctttg tgtcatatga acatgcttat tttttaattt gttaaattcg
    10141 taatagcaaa atataatcta atatttgtta aataattatc caaggaaaat caagtaatta
    10201 ttaatcaact ttatttttta attgatactt ctttgtctat aatttaaaca aaaggatata
    10261 aacttttaaa ttatttatta gttttcttag tattaatgtt tatattttta taaatatata
    10321 ttaataatat aaatagaata actaaaacca tgcttatttg ctatatgttt tatataatat
    10381 tatataacac tttttacatt agtaaaggat aaattgtata aaaattctgt taatttattt
    10441 ttataatttc atctttctaa taaaaacaaa gaagaagact taaaaattta taagtcctct
    10501 tcttttcaac gtgcattttt gtgctatatt taattaattc gacctttaat ttccatatcc
    10561 ttcctatgat aacaaaactc ttttattttt ttaatgattc attatcattt aaaacttctt
    10621 ttatatcaag tacttctttg ttatcatcac tcataacttc ctttattcct ttgaatgttc
    10681 ctaggaaatt aactgcttct gaaggtaaaa ccagttttgt tgacttacct tcagccattt
    10741 tttcaagagc ttccatagat tttaatgcta gaatattatt gtctatatca gcctctttca
    10801 ttgctgaaaa aactaatttt aaaccttctg ctgttgccat ttgagttctt tttatcattt
    10861 cagcttcacc ttgtgcctta gcaatagctg tctgtcttat agcttcagct tcaccttctg
    10921 ccactaatat agcagattct ttttcacctt ctgctacacg taccatagct tcttttttgg
    10981 cttctgctgt taatatagca gattgttttt caccttcagc ttgaagtatt gcagctgact
    11041 tattaccttc tgcttgaagt attgcctctc ttctttctct ttctgctctc atttgttttt
    11101 ccattgcaac ttgaatatcc tgaggaggca ttatattttt taactctact ctatttactt
    11161 ttatacccca tttatctgtt gcttcatcaa gaatagttct catttttaca tttattatat
    11221 ctcttgatgt taatgtttca tctaaatcaa gttcaccaat tatatttctt agtgttgtag
    11281 ctgttaaatt ttcaatagca gctattggat tagctatctc aaacacatat ctaactgggt
    11341 ctgtaacttt ataatataca actgtatcaa tctgcatagt tacattatct ttagttataa
    11401 ctggttgagg tggaaaatct attacaattt ctctaaggtc aattacatat gccattttat
    11461 ctaaaaatgg tattaagaaa tgtacacctg tttcagccac tttttgaaac ttaccaagtc
    11521 tcattattat acctacttta gattgtttta taactcttat acaagttaaa cttattgcta
    11581 cgactactac tattaataca atacttaaaa caattttagt acccatacta taaatcctcc
    11641 tttattctat tggtttgtca cattaactgt ggcgtctact tttttaacaa ctaattttac
    11701 cccttcaatt tttaatactt ctactgtaga acctttttct atcttttcac catctataga
    11761 aatagccgtc catgtttcat gttcaactac aactagacct gtgttatttg gagaaatctc
    11821 ttctgtaaca ataccttttt tagacatcat tgcttgtaaa ttagtgttag atttatagcc
    11881 tttatctttt tttactattt ttttagtagc tacgactaac attgctatag aaattactgc
    11941 aaatattaaa atttgtaaga aaatactctc tataaagcta cttaaaaata taagtattac
    12001 agctcctaca ctaaaccata tcaatgttaa gcttggtgtt aacatttctg ctattccaaa
    12061 taagactgct actatcaacc atattagctt catactatct accctctttt catatgaatt
    12121 ataaaaccct atataaatta tatgtttata caatgttttt gaatataaat ttaaattaca
    12181 aaacaataaa ataaattaat taattaatag tattatatca acatactttg ttaaaattgt
    12241 tacaaagtag tatcaaatat caccaattat atatccaaca actctttcat tgttaatgaa
    12301 atgttactta ttaaatccgt agcatttacc gtatacattg ctttgctcaa tttatctcct
    12361 atatagccat gtatatatgc tccactaact gtagcttcca atatatccat accttgacct
    12421 ataaatgaag taatcattcc aagcaaacaa tcacccattc caccagttgc catacagcta
    12481 tttcctgtag gatttatata tgttttttta ccatctgtta tgacagtttg ataacctttt
    12541 aaaagcacca ccagattata tttttgagca aattcttttg caacatctac tctatgttct
    12601 cttatatacc caattgaatc tcctgtcaac ctggccattt ctcccaaatg aggtgtaatt
    12661 acaaatctat ttttccattc taaaaactta taacatctgt ccttcataac gttcaatcca
    12721 tctgcatcta atactattgg gcaattagaa ttttctacta tcttaagtaa tttatcaaat
    12781 gtttgactat tatctcccat acctggacca aaaccaattg catcactaga attaagtaat
    12841 ttatttaatc tttcttcttc aaaatttaaa gtcattgctt ctgtaagtct aatagatacc
    12901 ttttcttgca catcttcact actaattaat gttacaagtc cactcccact cttaacagca
    12961 gattcagttg ctatgaaact tgcaccataa aatccttttg aacctgcaac tatagatact
    13021 tttccaaaat cacttttaaa accatgctta tctcttcttc taatattatt ttttacaaaa
    13081 gtcttatcag ttatgaactc ttcatcatgg tattttcttg taataaaatc tggaacacct
    13141 atcttttcta caactacatc acctataagt gcgctagtgt catagtttag aaaacctctt
    13201 ttataaaact caaagctaat cgttttgttt gctctaatac aagttcctaa tacatttcca
    13261 ttatcgctat ctatacctga aggaatatct atagaatacg tatttttgct attatcgttt
    13321 actatgtcaa taacttcttt aaaaatacca gttatatcac gttttaatcc agtcccaaat
    13381 atagcatcta ctacaacatc acttttagat actctatctt taaaaattgt taaattttta
    13441 ttttttataa tattttgttt ctcaacttta ataattttat ctacttcatt ttcctctcca
    13501 taattttttt cacttaaatc atttttatta atatttataa tattaattcc catatttaaa
    13561 agtacattgt aatttatttt agagcattca cttagttttt caagattacc tactaaaaat
    13621 acgtttactt cttttccata tgtatttaga tgtcttgcta ttccaagacc atctcctcca
    13681 ttatttccaa caccacatac aactgtataa ctattataca tgtctatatc catatttttc
    13741 attgcagata taaccgcatt ttccatcaat acaatcattg gaatccctac ttcttctaca
    13801 catgcagtat caacatttct gcttaattta gatgtaccta ttagcataaa ttatcactcc
    13861 tataaagtta aagacttctt aaatacttac caaaaatatc tattgaaatc tttttaatcc
    13921 cataaatatc ataaataaaa tcactaaaac taagagtttt gaaataattt aaaataacaa
    13981 aaaattttga attaaaacaa ttatttaatt tattatacca tataatttaa gttattatgt
    14041 tgatttaaaa cctatttaca ctaattatct aaatatctct ttatttttat aatcttttat
    14101 aacttattta tatttttcat ttttataaaa aaacaataat taagaatata actatattct
    14161 acatgtaaaa atttttttat ttaaactcaa ttttctgata atttgataat ttttcaaaat
    14221 ttatagttga cttttatttt ttactgtatt aaactaatta ctatacaaaa cagaaaacaa
    14281 aattttcaaa attattaaat taaaaggaga ggtaaatatg aagactttat taaacaaaca
    14341 agtacgattt tttagtagcc aatttagtta gggtttgtac ctaagttaag acaaattgtc
    14401 ataacataga tacaagcccc ttaggattat gatttttaag gattgtatct atgttggcta
    14461 tagtaattgt tgttaaagtt tttattttat catcataata tagagccaca tggattatac
    14521 tgtgtggctt attcgaattt ttgccataca gttatatata ctgtgtggtt tttttatatc
    14581 aaaatcattt tttaaaacca aattttaaaa accatttaaa atattttcaa aggggtgttt
    14641 tatttatgtc aggtattata tctgtaatga cgcaaagttt aattttatcg attatggcac
    14701 tgggggttta tataacttac aaaatcttag attttccaga tatgtctgct gatggtagct
    14761 atacaatggg tgcttctatt gtagcatttt ctcttactaa tggtatttct cctgtagtag
    14821 caactttaat ggctatctta tgtggttgta ctgctggtct tgttacaggg attcttcaca
    14881 ttaagtttaa gatatctaat ttactttctg gtattttagt tctgggaatg ctatactcta
    14941 tcaatttaag aataatggga aaatcaaata ttcctctatt tagctttaaa cacttattca
    15001 atggggaaat atctcctata gttttagcct tagcttttgt attcatctgt aaagtccttt
    15061 tagatttatt cctaaaaaca ggtcttggat acactttaaa aggtgttggt gataactctc
    15121 aaatgattaa atctctaggt ataaatatag gttctataaa aatactagga cttatgattt
    15181 caaatggact tatagcttta tctggtagtc ttatggctca gttcttggga ttctcagatg
    15241 taaatatggg tataggaact ttagttcttg gaattgcctc tatcataatt ggtattacac
    15301 tatttaagaa atttactttt atcaaagata ctactgcaat aattgttggc tcttttatat
    15361 accaattcac tatatacttt gcaatgagtt taggaatgtt atcaactgac ttaaaactaa
    15421 taactgccat agttataata gctttcctag ctactggtaa cttaaatatt tcactaaaaa
    15481 aaaacaaatg caaagctagt accaaaaata aatcagaaaa aagaggtgtt gtagatgtta
    15541 caaattaaaa atctttcaaa gagtttccct aatccatatg gtgaacctaa tactatcttt
    15601 gaaaatttat caatcgatat agaagatggt gaatttgtaa gtatcatagg tagtaatgga
    15661 actggtaaat ctactttatt aaatataata tctgggctta taaaagaatc ttctggtcaa
    15721 attactttag atagtactac tataacaaat ttagctgagt ataaaagaac tcaaatagta
    15781 agtagagttt ttcaagaccc aagccttgga acttgtcctt ctatgacggt tagagaaaat
    15841 ttatctctag cacttaataa agggaaatta ttgaacttaa aaaaatgtct tcgtcataaa
    15901 acgaatgact tggaacactt acttgaagga atttctttgg atttaaaaaa atatttagat
    15961 attaaagtac aatatctttc agggggtcaa agacaatcac tatcactaat tatgtctagc
    16021 ttagcaagtc ctaaggtctt attactagac gaacatacag cagcacttga cccaaaaaca
    16081 tcaaatgaag taatagagtt aacagataaa atcgtaagag agaaaaatat aactacactt
    16141 atggttactc acaacttgaa acacgctctt caatatggag ataggttgat aatgcttcat
    16201 aagggtgaag ttgtattaga tgtaaaagat aaagaaaaaa aagatttaac agttgaagaa
    16261 atcttagaaa aatttgaata tgcagtataa gaaattaaaa tcttagtttt aatcagaaat
    16321 atttataatc tatcatatga atatatgaac aaatataatt attaaatttt aagggaggaa
    16381 aataaaatga taaaaagtaa aaaaatatta agtttaatta tagcaggagt acttggtgta
    16441 tcaatgctta ctggatgttc tcaaaatgat ggctccaatg cttcaaatga aaataaagaa
    16501 acagatagca aaaaacaaaa aaatataggt attactcaat tagtggaaca tccatctctg
    16561 gataaagcaa agaaaggatt catcaaagca cttgaagata aaggctataa agatggagat
    16621 aatataaaaa tagatttcca aaatgcacaa aatgatatgc ctactacaca aagtattgct
    16681 agtaagtttg tatccgacaa aaaagatttg atatatgcta tatctactcc atctgcacaa
    16741 gcagcttata atgctactaa agatattcca ataataatga ctgctgttac agaccctgta
    16801 gaagctggac ttgttaaatc tcttgaaaaa ccaggtggaa atgtttctgg tacatctgat
    16861 tatctttcaa ttgataaaac attagaattg gttaaaacat tgactccaaa agcaaagaaa
    16921 ataggggtta tatacaatac tagtgaagtt aattcaaaaa tccaagttga ttctctacat
    16981 gattatgcta agaaaaataa ttatgaagta gttgaaaaag gaatcagctc ttcaagtgaa
    17041 gttaaccaag ctatttctag tttagttggt aaaatagatg ttttatatgt ccctactgac
    17101 aatttaatag tttcttctat gccaatagtt tctaaagttg ctaatgaaaa caagattcct
    17161 ataatagcct ctgaagaagg ttctgtatct tctggtgctt tagcttgttg tggaatagat
    17221 tatgaaaaac taggttataa ggctggagaa cttgctattg aagtattaga aggaaaatct
    17281 gttggcgata taccagttac tacattagat gaaactgaaa taataattaa cgaagataca
    17341 ctaaaagcac ttgacatgca aaagttatca gcagataata taaagtatat aaagtcagat
    17401 gaaaatgcaa aatctacaaa ataaaactta ttaatttcaa aaaataggta atatgaagta
    17461 ggtaatatga aaactttata taataagtac tcttatccac cctaaccctt tgaaaattgt
    17521 gcttattgta gcaatttgaa tattgcatat aaagttattc attttccata aaagtcgtct
    17581 atattgacga ctgattatga aagttatata actttctaat cactacttga gctgtccaaa
    17641 agaattttaa tattctccag acagcttttt tttatgatat ttgattgata tacatgtcta
    17701 gttattccat atttagtaaa tattttgata aaatttccac attcacttat aacttaggat
    17761 aacgtttttt tcaaacaata cattaattta aaagtattct gagtatacat tatttagtat
    17821 tttaattaaa tttagcagtt gacttttatt attgtataat ttataattta taacaagtcg
    17881 agaatacata taattttctg actaattaaa atattaaaag ggagagataa ttatgaatac
    17941 tttattaaac aatagaaaat attattatta ttatagccac tatttttagg gtttgtacct
    18001 acgttttaac atagatacag accccttaag actactaaaa ttttgggatt gtatctatgt
    18061 tggctatatt gtttataaag ttttcatcta actatataag agccacatag attaaactat
    18121 gtggcttatt cgtgttttta ccacatagtt ttgtacacta tgtggttttt ttatacacaa
    18181 aattagcaaa taattaaaat tataaaaata ttttcaaagg agtgttttat ttatgtcagg
    18241 tattatatct gtaatgacgc aaagtttaat tttatcgatt atggcactgg gggtttatat
    18301 aacttacaaa atcttagatt ttccagatat gtctgctgat ggtagctaca caatgggtgc
    18361 ttctattgta gcattttctc ttactaatgg tatttctcct gtagtagcaa ctttaatggc
    18421 tatcttatgt ggttgtactg ctggtcttgt tacagggatt cttcacatta agtttaagat
    18481 atctaactta ctttctggta ttttagttat gggaatgcta tactctatca atttaagaat
    18541 aatgggaaaa tcaaatattc ctctatttag ctttaaacac ttattcaatg gggaaatatc
    18601 tcctatagtt ttagccttag cttttgtatt catctgtaaa gtccttttag atttattcct
    18661 aaaaacaggt cttggataca ctttaaaagg tgttggtgat aactctcaaa tgattaaatc
    18721 cctaggtata aatatcggtt ctataaaaat actaggactt atgatttcaa acggacttat
    18781 agctttatct ggtagtctta tggctcagtt cttgggattc tcagatgtaa atatgggtat
    18841 aggaacttta gttcttggaa ttgcctctat cataattggt attacactat ttaagaaatt
    18901 tacttttatc aaagatacta ctgcaataat tgttggctct tttatatacc aattcactat
    18961 atactttgca atgagtttag gaatgttatc aactgactta aaactaataa ctgccatagt
    19021 tataatatct ttcctagcta ctggtaactt aaatatttca ctaaaaaaaa acaaatgcaa
    19081 agctagtacc aaaaataaat cagaaaaaag aggtgttgta gatgttacaa attaaaaatc
    19141 tttcaaagag tttccctaat ccatatggtg aacctaatac tatctttgaa aatttatcaa
    19201 tcgatataga agatggtgaa tttgtaagta tcataggtag taatggaact ggtaaatcta
    19261 ctttattaaa tataatatcc gggcttataa aagaatcttc tggtcaagta ttattaaata
    19321 aacataactt gtctaattta gctgaacaca gaagaactca aatagtaagt agagtttttc
    19381 aagacccaag tcttggaact tgcccttcta tgactgttag agaaaacttg tctttagctc
    19441 ttaacaaagg aaaactatta aatctaagaa aatgtcttcg ttacaaaaga gatttcttag
    19501 aaaatttatt ggaaggtgta tctcttgatt taaaaaaata ccttgatgtt caagtaaaat
    19561 ttttatcagg aggtcaaaga caatcattat cactaattat gtcgtgctta acaaatccat
    19621 cagttttatt acttgatgaa catacagcag cacttgaccc aaaaacatca aatgaagtaa
    19681 ttgaattgac taataagatt gtaagggaaa aaaatataac tacacttatg gttactcaca
    19741 acttaaaaca cgctcttcat tatggtgata gattgataat gcttcataag ggtgaagttg
    19801 tattagatgt aaaaggtaaa gaaaaagaac aattaacagt tgaagaaatc ttagaaaaat
    19861 ttgaatatgc agtttaaaat aatatatcta ttgtattaaa ctcggcttta aaataaagtt
    19921 aaaattacaa taattatggt tactttgtaa taattcatat gaatatatga acatatataa
    19981 caataaattt ttgaggggga tataaaaatg attaataaaa aaagattggc aagtttgatt
    20041 ttagctggtg ctcttagtat atctatgctt acagggtgtt cacaaggagg agactctggt
    20101 aattcaaaac aagaaagtaa ttctaaaggt aaagaagtta aaaaaattgg tataactcaa
    20161 ctggttgaac atccagcatt agatgccact aggacaggtt ttgtaaaagc attagaaaag
    20221 aacggattta aagatggaga aaatattgat atagacttcc aaaatgctca aaatgacatg
    20281 cctactacac aaagtattgc gagtaaattt gcatctgata agaaggactt aatatttgct
    20341 atatctactc catcagctca ggcagcattt aatgctacta aagatatacc tatacttatt
    20401 actgctgtga gtgaccctgt tgctgctgga ttagttaaaa ctcttgaaaa gccaggcaca
    20461 aatgtatctg gaacatcaga ttttgtttct gtagacaaag gtttagaact tcttaaaata
    20521 tttgctccta aggcaaaaac tataggagtt atgtacaata ctagtgaagt aaattccaaa
    20581 gttcaagttg atgctttaaa agaatatgca tctaaaaatg gatttaaagt tgttgaaaaa
    20641 ggtataacta cttcaaatga agttaaccaa ggtatttcta gtttagttgg caaaatagac
    20701 gtattatatg tccctacaga taacttagtg gcttcttcta tgcctatagt ctctaaaata
    20761 gctactgaga ataaaatacc tgttatagca gctgaatctg gtccagttga aaaaggtgct
    20821 cttgcttgtc aaggtatcaa ctacgaaaaa ctaggttaca aaacaggtga aatggcagtt
    20881 aaaattttaa atggcgaatc agtatctgat atgcctgtgg ctacatcaga tgatacagat
    20941 atcattgtta atgaagatat attaaaagct ttaggtatgg aaaaaccttc taatgaaaat
    21001 atttcttatg taaagactaa acaagaatag aaagatattt tctatatacg attaatatgc
    21061 ctgtttctat aaattaattt atagaaacag gcatatattt ttattttaat gtattatcta
    21121 tttaaagatt atatgtaaat gctcttaatt tgtttgtata aattttactt gtataaactt
    21181 tatacaatca tatttattct tctattttct ttattactct acatggattt ccaacagcta
    21241 cagtatttgg tggtatatct tttgtgacta cacttcctgc acctattact acattatcac
    21301 ctatagtaat tcctggtgtt atgattactc ccccacctat ccatacatta tcacctattt
    21361 ttataggaga accatactct atgcctgaat ttctaagttg tgcatcaatt ggatgatagg
    21421 ctgtatagat ttgaacgttt ggagctaaca ttacattgtc acctatttca attttacata
    21481 catctaaaaa aatacaatca taatttgcaa agaaattttc gcctacatgt atgttatatc
    21541 cataatcaca cctaatattt tgttctacat ttatttgctt gccaactgaa ccaaatagtt
    21601 gtcttaaaat atcttctctt ttttcatatt catcctctaa agtattatta aacaatctag
    21661 ttaatttttt acaatactct ctttctttta ctaacaattc atcatttgca tagtatcctt
    21721 tcccagacaa cattttttct ttttcagtca tatagtttac tcctttttgt tataattgta
    21781 tctaaagcaa aataaatatt cctgtggaaa atctaaatat attctgtcac ctttcttaaa
    21841 tctcatttta cttttttcca attctatttg aataggtaca cattcgttag ataaatcagt
    21901 ttttctaaca tatatagtat atgtaaaagg attttctaca atgttaatca attcgaaaca
    21961 taacttttca tttaaatctt cattagaatc caagacctta atatgatgct ccctgattcc
    22021 cacatattct atattatcac ctatttctct atttaatgtc aactcgcatc cccagtctgt
    22081 agcataaata gtatttttat ccagtctatt taatttggat atatttttac accctgttat
    22141 cttagcttct ataaggtact ttggagattc aaagagctct tttttaggtc tctttggaag
    22201 accttctcct ttgttgtaca ctataatatc atcacaaact cggtaagctt cttcaatatc
    22261 atgagtaaca aatagtatat ctcccttgta atcttttaac atattcataa gttctttttc
    22321 catattgctt cttaaatgat ggtccaatgc tgagaaaggt tcatctaaaa gtaatatatc
    22381 tggagatgtt gccaatgctc tagctagtgc taccctttgt tgttgaccac cagataattg
    22441 ccaagggtat ctcccctcaa acccatttaa tttaagtata tctaagtacc ttgctactat
    22501 ttcctttttt tcactcttac ttagttttaa aagcccaagt tctatatttt gacttacagt
    22561 catatgtgga aacaaagcat agttttgaaa taaaaatcct acctttctat cttgtgttga
    22621 taaatttatc ttcttttcag aatcaaatag aactctatca tttaatacaa ttttacctct
    22681 tgttggtttc tcaagccctg ctatacattt taatgtcata ctttttccag aaccagattc
    22741 tcccaaaaac cccagagtac ctttttcttg tttaatttct acctttagtt taaaagagga
    22801 taaatctttt tcaatatcca cgtataagct caactatcca cacctctttc ctataatttt
    22861 ctgctgaaat tccgaccaat aatttagtaa taaaatcatt gctatagata ttgctacaat
    22921 aatcataacc cacatcatag ctttattcat atctccgcct tcaacagcaa aaaatatagc
    22981 tattggcata gtttgagttt ttccaggtat atttccagct atcataagtg tagcaccaaa
    23041 ttctccaaga gctctggcaa acgacagcac caatccacca attattccag gccatgctaa
    23101 tggaactgca atcttaaaaa atactttcca ttcattaaga cctaatgttc tagcagctga
    23161 caacatatta ttatcaatct gttcaaaagc tgaccttgaa gttctataca tcataggaaa
    23221 agacaccact actgctgaaa ttacagttgc tgtccaacta aatattaaag tcctatcgaa
    23281 atttaataaa aactttccta taaatccatt cttcccacat agtaataata aaaagaaacc
    23341 tacaactgtt ggtggcaaaa ttagtggaag tgtaaatagt ccatctataa gacccttcca
    23401 cttacctcta tagttagcca taatatatga cacaaatatt cctattacaa aagttattat
    23461 tgttgacaaa atagatgtct taagtgatat ccataagggt gaccaatctg ttcccatctt
    23521 tccctcctta attttaaatg gaaatagtga aactaataac tctattaatt tcactatttc
    23581 cattttatta taatacacaa ttattttcaa ttttcattta tttatatata atttatactt
    23641 aattacacat aatttatttc taagtttatt ctactttttt atatccaaat tcttcaaaaa
    23701 tcttttgtcc tgactcactt aataaaaatt cttcaaattt cttagcagca tctacgtttt
    23761 tactagcttt aattactgaa actggatatg taataggcga atgagttttt tcgtctgttt
    23821 tttcaactac ttttatctta tcattattga cagtatcact gaagtaaacg aatccaacat
    23881 cagcatttcc tgattgcacc catgctaaaa cttcttttac atcttttgca aatactagct
    23941 tatcttttaa cttatctttt aaatttaaat tagttaacac ctcatctgca tacttaccag
    24001 ctggaacact ttcagcttca ccaacagcaa ttttcttcac tttatctgta gtcaaatctt
    24061 tcatacctga tacactactg tcagcagaag aaataagaac taaatcattt tttactaaat
    24121 ctttcatagt atcagaaact aataacttct cttcatccaa agctttcatt tgtttttgac
    24181 ctgctgaaat aaataaatca caaggtgctc cttgttctat ttgttgttgt aatgagcctg
    24241 atgctccata gttaactgta agttttacat ttgaatcaac ttttttatat tcttcttcaa
    24301 tctttgccat tgcttctttt aaacttgcag cagccgatat atttaactct actgaatcac
    24361 tacttttagt tgttttttct tgttttccat catctttttt gtcttcatta ctattgcacc
    24421 caactgtccc caaagttaaa catgcaacta atcctaatat tcccaatatt tttttcataa
    24481 caatctccct ttttgtaaat ttgatacaca ttttaacatg ttttattatg ttttatcatg
    24541 ttttgttata tatagtttaa ttatatatac atgataataa attttcaagt aatttattta
    24601 cactactttt aaatattttg ctacattttc ctttttttaa tgttaaaata accttatatg
    24661 gaggtggatt atggactcat tatcatcttt gacacctgtc gaggtagctg aattattaaa
    24721 gataacaaaa aatactgtat atgaattaat caaaagaggt gaacttcctt cttataaagt
    24781 agggaaaaaa ataagagttg atactaaaga tgttgaagaa tatatcaaca gccaaaaaac
    24841 tggtaaagta aaggatacac atttcaacaa taaaaatata gatataaata ataatttcaa
    24901 aattattatt tctggtcaag atgtaatatt agacatttta gctaggtctg ttgaaaaaaa
    24961 attggatgga ataagtacat ttcgctctta tataggtagt tataatgctt tgtatgagtt
    25021 atataatggc agagtttcta tagcatcatc ccatctatgg gatttcgaaa cggatgaata
    25081 taatagcact tttgttaaaa agctattgcc aggaatacca tgtgtactta taaatctagc
    25141 ttatagaatg caaggtttct atgttgctaa aggaaatcct aaagagataa caacctggga
    25201 ggatttaaca aaaccaagta taaccattgt aaatagggaa aaaggttctg gaactagggt
    25261 tttactagat ggtaaactta gacttctaaa ctttaatggt aaacatataa aaggttatga
    25321 taatgaagaa ttatcacatc ttggagttgc aagtactgtt tctcgtggaa tagcagatgt
    25381 tggtttggga aatgaaaaag ctgctttaca agtaaataat atcgacttta ttcctcttca
    25441 caaagagcgc tatgatttag ttattaaaaa agaagactta caaaatccag tttaccaaac
    25501 tataattaac ataataaact ctcctgagtt taaagctgaa cttcaaggtc ttggcggata
    25561 tgatttaact gatactggaa aaactatagc aaaagtttaa gattaaaatc gcaatctatt
    25621 ttataagatt tataattttt cacaaaattt ataacttaaa cacgaaataa attgcgattt
    25681 tagtgtctca aaaaatttat gtctttcatt ttatcatcca atacaaaata taatataatt
    25741 aattgtgcaa tcatattata ttaatatata tttacataat agtatttttc tttaatgtag
    25801 attaacatat gatatgtttt aaacatcaat ccccttgctt tcttatatat atttggcaac
    25861 acatatgagt ttaataaatt atatacaatg ttgctttctt cttgtatttt ttcaaccaac
    25921 aagttattta taaaattacc tttctcattt tcaataatct cactccaatt tatcttaact
    25981 tttaatatat atcttcccac taggtataca cactctacaa taaataataa aaatacaatg
    26041 cagtcagtac ctgttgtctt atataaatta cccgatacta atggctttgc gaagaaatta
    26101 taaaaattca aagtatcacc cgtataatca aaaagtatta atagcactcc tagaactctc
    26161 aatactttaa tattcaacat gtttttatct ttattatttt tgtttttcat atatactacc
    26221 tctcttttct ttagatttga ttgtaatcta atactaactc ttttatttga ggtataaatg
    26281 aatttaattg gtagttattt tcatttttac tagaaattaa ttcacattac taaacaaaac
    26341 ttatatttaa acataaaaat agcctatcta ttttttaata aatacaaaaa taaataagct
    26401 actaatattc aattaacttt tatcacttaa aacattacta tctataaatt taaatatttt
    26461 attgaagtat actgtactat catgttcaaa tccatcaaca tgaccaatac cttctataag
    26521 ccataggtct tttttatcat gtttaactaa atcatacatt ttcttgctat tttgataatt
    26581 acaaacagta tcttttgttc catgtataaa cagtatgggt acattagatt tctcaactga
    26641 ctcatatggt tttacatcac tgtaccaaaa tccagattta aacttattat ataaatctcc
    26701 acaagtcacc acataattga ttaatatatc tggtattcgt ttttctagta ctcccattct
    26761 aattgcatct ttcatttcag aataaggaga atccagtata taaaaatcga ccttatcatc
    26821 ttttgaattt atctctgaat gcatagcagc tgtccctgcc cccatggaaa atccatgcac
    26881 tcctaatctt ccttcaggaa atttattttt tacaaattta actagactat ctaaatcata
    26941 cctttcataa agaccaaatg tgtaattatc tccaccacta ttaccagtat ttctttgatt
    27001 ataaactaat acgttataac ctttatctaa atatctatat gctaccttta acatttcata
    27061 gtaactactt ccaattccat gaacaagtat catagtatct cttgtcttta tatttgaagt
    27121 tataaaaaga ctttcaagct tgtaattatt agaactttgt atcattaatt cagatgtctt
    27181 gtagtttttt aatttctcca gtggtctatc ttttctctca gaaaatattt ttactatatc
    27241 ttcgtttttt attaactgct ctaaaccaac tgaactatta tacactaatt tgccaaatat
    27301 ataagataca attaatagga ttaatagaaa cacaattgat ataattataa atttatttct
    27361 taaactaata caatttttaa aactattttt catatttatt taccatacaa ttttcctata
    27421 ttatattttc taagtaatag cataattgat tatactattc ttataatttc tattatacct
    27481 acttatttat taaaaataca aattatattt tattaatttt tactacttgt aaattattat
    27541 cttatacaat gaatttgtat tatataataa gtatttttag gattctgtta cataatatta
    27601 tttaaatatt cttctatatt tctcttcttc ttcttcagta aacacattaa atacaacttt
    27661 taaatttttt tcaggatttt cttttagcca tagtctaact ctacttacag caagattagc
    27721 tgcctctttt tttggataac caaatacacc tgtagaaatt ccacaaaaaa caatattttt
    27781 tatttcatca atttctttta ttgtatttaa acatgattta taacaatgaa gcagttgctt
    27841 ttcttgctct ttacttggct gaccaccaga tacaataggt ccaacagtat gtactacaaa
    27901 ttttgcaggt aaacaataac ctctagttat cttagcatct ccagtatatt ctaaatgccc
    27961 ttgttttttt attattttgt cacaatcttc tctaagtcta ggacctgcgc atgaatgtat
    28021 ctcattatcc acgcatagat gtaatggttg taaacaccct aataacttgt tatttgcagc
    28081 atttactatt gcatctgctc ttaaattcgt tatattacct ctccatatgg caatcccttc
    28141 ctctatttct tctatatcat ttacatctac taactctctt tcttcacatt caatcaacaa
    28201 taaattatgt aacatattaa gtatctctgg agcaatttct tttggtggat atacattcaa
    28261 aagtcctcta agtatatctc taggcttaat ttcatcattt gataaattgt atattttaga
    28321 aggaacttct tttgaaaaat atgcaattaa agtgtttata ttttttcttc tttgttcgtc
    28381 agttagaggc ttgatagttt tatcaaaatc ctcaaataaa tttacatcat cagcataatc
    28441 tctccacttc atagccatct ctccattctt gtattttaga cttaaaaata attatgtatt
    28501 tatgtacata tttatttatt tctataaaca cctacataaa tcctgttaaa agtgtaaatt
    28561 ttttattatg caacttctct ggttatttct attgattgat agtaaattat tgtacctaaa
    28621 tttaatccaa ctaacaagta actaaaccta ctttcctaac tgcaaaatac actatgtttg
    28681 ccacttgtat ctcatttgta aataaataaa gtccctacaa atacattaac taggctatgt
    28741 actaaactgt aggaacttta aaaatatatt attcttaatt aagttttggc caataatttt
    28801 tatttgcttc tattaaatca tctagtaatt cttttgcaac tgttgcacta ggaactgtct
    28861 tagatagcat aagtgcttgc cacaatttat tataagactt ctcaatccaa gcatcaacta
    28921 ctaatttttc aactgctaat tgttgttcta ttaaaccttt ttggaatgtt ggtattttcc
    28981 ctattgataa tggttcatac ccgtcttttc caactataca tggaatttca accatagcat
    29041 catcttgtat attttctata gctccattat tttgaactat caataacata cgctcctgtg
    29101 tattaaaagc tagagctgta gctaaatcca ctataaactc tgcatgtatt cctatcttaa
    29161 gcccactgcc cttagaatgt ccttgctttt ctatcaatgc acatgaacca aaaacttctt
    29221 tttctcttcc atcaataact tcattggcac gagtataatt tacatcagaa tgatttacaa
    29281 cataatctgg aaatagatag tactttaagt aactacttgg tattgtagtt aaatctgttt
    29341 ttactatttc tttagtaaat aaattagttt caaaccaact atctttcttg tcatttttca
    29401 ttccttcttc accatttata aaaccatatt cttttatatg ttctactaat tttggtaaaa
    29461 gttcatttcc ttttttatct ttaattgaag tataccaacc aaagtggttt aatccaaagt
    29521 atcttatatc catatgttta cgagatttga gtcctgcaat ccttgctata ttatgttcca
    29581 tacctattgg catatcacaa atatttatta ccctagaatt aggtctcaac cttctaacag
    29641 cttccgctat tattgatgct ggattagaat aatttaacat ccaacaattt ggagaatact
    29701 tttccatata atctatgttt tcaagaacac cttctataga cctcattcca taagctattc
    29761 cacctggtcc acaagtttct tgaccaacta ccccatgttt tagaggtatc ttttcatcta
    29821 gttctctcat ttcaagtttt ccaactctta tatgagctaa acaaaaatct acatctgtat
    29881 aagcctcttt agggcatgtt gttgctaaat actctatatt agggtccttt tcctttatta
    29941 gtatttcaca agctttagct accttatttt gtctttcttc atcattatca tataatttga
    30001 ttgctcttaa tggtaaccta tctaagttat ctagcaacat taatatgatt tctggggtat
    30061 atgtacttcc tcctccagct attactactg aaaatttttc cataataata tctccttttc
    30121 tatttaaaaa tttactgtat ttataaataa atttataaat actagtactt taaagtaaaa
    30181 gggagttcat ttattaaatc tattgattta ataaactata gccaaacttc aagcactatt
    30241 tacaagaaat ttaattctta ttaattcttg ggtccatcat ctcaaatata tctacaagtt
    30301 cagatactaa agaatgagca aataatgcat ttgaataatg gtcttcagag tgcacaacta
    30361 aaaaatcagt cccactatct tcactattca tagcatttga tagtaattct aaatgatgct
    30421 ttgatgctgt ttgtattttc tctgaggctg aatttaaaag gtgttttgct ttattgtagt
    30481 cacctttttt tatttcctta agagacatca ttacatcact tttagcatct cctgcttctg
    30541 atattatact aaatactttt tcttccattt caggtaccat atccttctcc ttctaatgac
    30601 ttgttaaaaa tcaaagctat catcatctaa tgttgtagct aattctgcat ttttatttaa
    30661 ttcttccttc tccattatct taaagaatgg ataatatatc aaggtcataa gtattatact
    30721 tgcaaatact aatacgattg ccttccaatc taatgtcatc aaaaatgctg caacccctgg
    30781 aggtaaaaag cctggtggtt ctgcaatagg taatcctact aatcctactt ttaatgccat
    30841 aaaattaagt gctccaacca atacaggtcc aaatacaaat ggtacaaaca tatatgggtt
    30901 cataactatt ggtgttccaa atattaccgg ctcatttatt ccaaatagtg atggtaaaat
    30961 cacaactttt cccatactat taaaactctt acacttactt cttgacataa ggtacactaa
    31021 tcccaaagtt atccctgaac cagttacttg caagaaacca tagtaaaaac ctattgtaaa
    31081 cacatatttt gggtctcctc ctgctgctat taacgttgca ttttctgcca tatatgtagc
    31141 tgctattggc atccatatac ttgaagttat tgctgctcca tgaagcccaa agaaccataa
    31201 taattgagtt ataaatagta ttatagttac tgcaaaaaca ttatctacac tgcttatagc
    31261 tggtgctaag aaattcatta taatagctgg taatggttga cctgagacat ttttagttat
    31321 tgctgctatt gctgtaaata acattataca tactatcatt ggagttaagt ttctaaaact
    31381 tttatttact acactaggta cttcttttgg aaatctaatt acgagatttt tatcattcat
    31441 aaacttagta atatcaacta ctaaaagtgc tactaatata cttacaaata aaccttgtgc
    31501 atctaaataa cttgtatcta atacaccatc tactacttgt ccacatacaa caagttgtgc
    31561 aacaactgct gtcataccta tttctacatg attaagatta tattttttag ctagtgcctg
    31621 agctataaaa aatgctgaat atatagataa taaactcata gtaaatttat tagggataag
    31681 taatgtatcc atattttcag ataataatgt ttttgcactt ccttcaggta acatattgtt
    31741 taatgccata aataacatac ttaaagaacc aacaattatt attggggtaa tgcttatcat
    31801 accttctttt atagcttgaa gatgcctttg tttttcaatc ttttgtgcta ttggaagaag
    31861 aaatcttctt aaattatttt gaagtgcttc catttttatt ccccccaatt atctattttt
    31921 atataattcg attgccgact tcataacaga aggagcatcc atacgaccat aatgcttagt
    31981 atctattaaa ccaactgcta ttttgtaatt cttacaagct tcaactacat catcttcctt
    32041 aaacctaatt tgtggtgcta caagtactac atcggtatca ttagcttcaa tgtatgattt
    32101 taaattttca aatgatgttg cctctatatt tatagtttta gtttttaact tttcatgctc
    32161 actacaaaaa cttttcatct tttccacaag tacacctgtt gaagctccat ttgcacatac
    32221 taataaaata ttcataatta ccctcctaca atatctaacc tcttttattt tctaattttt
    32281 tatcagccaa ttcttactct aattcctatc agtttttact ttaattctta ttattttatt
    32341 ttaattctta ttaatattta ctctaattct tagtactgcc aatgattaaa cttgaaagcc
    32401 gtatctataa cttcttcttg cttatatttt tctaatattt ttaagtatct ttctttataa
    32461 tcattatcta cttctttttc tggtattact atactagctt catttaaaaa gtggaatgaa
    32521 tcccttccca tttctaatcc tctatatgta tgcttgtcaa gtgccacgtc cataacttct
    32581 ggaactttac ccattgcaaa tccttttata attatatttt ttaataaatc acttgatcta
    32641 tctttctcac atgcacaaag atatcttatt gcatgtatga aaaataaagg tctgtctcca
    32701 tctgcatatg aatattcctt tcttacttga tttaaattat ttatgattat tacagctgat
    32761 gggtccccca ttcctatatc ttcaactgat attgtaagta tccttctcca tagcttatct
    32821 tctaattctg gtgatgatat atatagttca taagcaaatt cacaagcttc ttccaccata
    32881 tttcttctta tagctttttg aaatgacgat attatttcat ctgcactaaa tccgtttctt
    32941 gtagtcattc ttgcccatgg gtcatttgcc tttttatctc ttaatatttt atcttgcata
    33001 ttatttactc ctttttattt aaattttaat tatttatatt actcatttaa taatataagc
    33061 aagtattatg ccagtttttt tagacacttt aaaacactgt tatttcaatc atttttatca
    33121 tcaaaactta gatactttgt ctaagtatat ttatatgtgt ctaatattaa tattatttta
    33181 gactaaaaaa aattaccaaa taagttttta tactcattgg taatcttttt cgattatttc
    33241 tgcatattct aatattaata atatttgata gcactctttt tcattaattt ctatattata
    33301 ttttttatct aattgagata ctatatcttt tattttgctt aggctcttgt gataatcaag
    33361 tgttttttct ttatcaagct tttcaatttc tctagtattt ccaatcaatc catctaccat
    33421 gaaagctaaa tgcatcataa gtccaattac tttatcgtat ttcttttcta tattaaatac
    33481 taaaaacaat tcatcagaca catattttat atctttaaat atcctattat aattagagct
    33541 ttttaaggat gtctttaaac cttcaactac atcatcataa cctatactta tctttataat
    33601 attttttaat ttattgatat tttcatcctt atctatatct tttttgctaa tatagtcaat
    33661 tcctctaata ttaattcttt gttcattgat tactgcaaca atattactac tttctttaag
    33721 tttcgtaata tttaaactta aatctttttc tgttttatat gggacagata taatatctat
    33781 tccatctaag tacctactca tcttttcttc taatattttt cttgttttat tatctacacc
    33841 ttctgaaaca tgtgatgcta taataattgt tttagacaga ttttctttat tttgaatttc
    33901 attagttcca aaatagtact ttctcgtgtt agttatagag ttgtatacgt catttaaagg
    33961 taatcccata ttggccttct gaactgcttc taacacagtt aatgttgtca ccataggaat
    34021 tactcttact ccacactttt tttctttctt tataatttca tcaaaagagt ttaatgaacc
    34081 catatctgta aatagtaata catctttatt gtctatatta ttaattaaat ttttaaaatc
    34141 tacaataact tcatcatagc ttttatctaa cttcatatcg aaagaaatag cactgcactt
    34201 tccaataata tcaccaactg cttttaccat actacttgct gtagtttctc catgcatagc
    34261 aactataata ttaatgttat tcactatttt attttgttca tcttgtttag cttgtactat
    34321 gaataatgta atatatgcta cagtttctat agataaaaat aaatcaaatt cattttcaat
    34381 tattccaact atttttagtg ctgttttaaa ttcacttctg ttatttcttc taatttgatt
    34441 caaatctatg ttgtttgtag agctactttt atccaatacg ctttttatat aaattgccat
    34501 tgacttaaat attgattcac ttatgtctat ttcttcatct tctttaataa tttgtcttat
    34561 tgattcacac atgcttttaa acttaacatt attaaataga gaagcatctg ctatattcat
    34621 ttctacagat ttattaagat tagtatttac tgcattaata atatttatat cattgtagtt
    34681 aataacttct tcttctccta atgacgtaaa tacaaaatat tctattccat gtgttataac
    34741 ttcatctgct ttaatagact tctctctata atcatcactc acttcattta tagatttatc
    34801 aaaatatttt ttctctatat aaactggttc tttattatct cttttatatc ttaggtatcc
    34861 atttgcaaca gctaatttta tatcattttg aagttgacct acattatttt tacaatcata
    34921 aagtaatagt gatttaatta tttctttatg tacttttatt gaaatagaaa tactttttga
    34981 ttcttccttg aaaaaatttt tgactaattc cattctttca atcattgtcc tatctctcag
    35041 tgatggtatt tctattttca ttggtattct tctattgaat gtatctaata gtgttgatgt
    35101 cggattttct gtagtagcac atattattaa taccttagac tctctttctt tcgttgcatc
    35161 tcctagtctt ttaaatgttc ccttatctat aaaagtaaac aacatttctt gaccttctgc
    35221 tggtagtcta tgaatttcat ctaaaaatag tatccctcca tttgcaattt ccaaaagacc
    35281 ttttctggaa gattctgcac ctgtataagc tccttgttct accccaaaaa tatgtcccat
    35341 aagtaattgt gcattattag cataatcagc acaattaaat gttacaaaag gagctttatt
    35401 ttttctaatt ccactatcta tagaataatc gtacatatat ctagcaatca tactctttcc
    35461 tactcctgtt tctccataga taatagtatg aagtccattt gtaggataga gcattgcgac
    35521 cttgcatttt tctattatag gtcttaaact atgttcttta cctattagtg tttcaaaact
    35581 atcttttttt attttgtttt ctacttttgt tccttttttt atgccaagca actcactttg
    35641 tgtatcaagc aattcattct tgttaaggtt aagatttgca gggatataat acacaggtct
    35701 tccttttatc ttcgtaacca taccctcatt gaataattgg tttaaatatg tacttatatt
    35761 gtttcttgca attcctgtct tttctgataa ttggttagct gtaatccctt tttcattttc
    35821 cctatatgat gattctaaaa ctttcattac tttatctttt ttatatatca ttacaagctc
    35881 ccctacatta tagtatttta ttaactaaaa cccctataca cactttattt tttaataaac
    35941 tcttattctt taactaaggt tataatttat caaactttcc ttactttaaa ttatagaaaa
    36001 ttattgtaga aaaaataaga ttattgctca ttttttctac attactattt ttaattttat
    36061 agtactttct taacaacata ctttacttgt ttttaatttt attatatttg aatttattat
    36121 atttgaaaag tagaaataaa aaaccctatt ttggagtagt tttaaaattt ctccaaaaat
    36181 agggttttag tttgtatttc aaataaatac ctgttcaagt atttttatac taaacaactt
    36241 ttaaattttg ttgatattta tttatttctg atttagaaga atatacaaaa tgtccatctg
    36301 aaacatcaat ccaacttaat gacttttcat ttgaacaatc atatccatta gaattatact
    36361 ctattctatt tcttgactta gcatatctag ggtcaggaac aggaattgca gaaagtagtg
    36421 attttgtata tggatgaata ggattattat acaattcatt tgaatctgcc aattctacta
    36481 attttccatt atacataact cctatacggt cactaatatg tctcaccata gataaatcat
    36541 gagctataaa taaacaagtt aaattctttt cttgttgcaa ttttttaaat aaatttacta
    36601 tttgtgcttg tatagacaca tccaaagaag ctataggctc atcagctatt ataaattctg
    36661 ggtctactga aagagctcgt gctatgccaa tacgctgtct ttgtccacct gaaaaatcag
    36721 atggatactt atttgcataa cttctatcaa gtcctactag ctttagcatc tcatatactt
    36781 tattcattct atctgtttta tttttacaga taccttgaat ttttagtggc tctgaaatta
    36841 tatctgcaat tgtcatacgt ggatttaatg atgaagtaga atcttgaaaa ataatctgca
    36901 tacttttgtt tacatctttt tttataaatt tgtacgtttt tttatctgat atgcaatttc
    36961 ctttgtaaat tacttctcca ccagtagatt catgtagtct tattatagtt ttaccagttg
    37021 tagattttcc tgaacccgac tctcctacca atccaaatat ctcaccctta tatatatcaa
    37081 aacttatatc atcaactgct tttacagtag tacttttgtc caaatgaaaa tattgcttta
    37141 agttttttat ttccagtatt ttttctctat tcattagaaa tcacccttcc acaatttact
    37201 ctaactggta catctacttc aggtgcatct gggtgcaata accaagttgc tgcactatgt
    37261 gtatcattaa ttttaaacat tggtggctct ttttcataat ctatcttaag tgcattttta
    37321 ttccttattg caaaagcatc tccttttggt gggttcaata aatttggagg cattccaggt
    37381 atattatata aatagtcatc ctgcgaatct aaagtaggta atgaacccaa caacccccaa
    37441 gtatatggat gtctagggtc ataaaatata tcctctacag ttcctatttc tacaatcttt
    37501 cctgcataca taactgctat tctatcagct atagttgcaa ctactcctaa atcatgagtt
    37561 ataaatatta ttgacaaacc tattttatgt tgtaaatcct ttattaaatc aattatttga
    37621 gcttgtatag ttacatctaa agcagttgta ggttcatcag caatcaatac atctggatta
    37681 caagcaagtg ctatagctat tactatacgt tgtctcattc cacctgaaaa atgatgtgga
    37741 aattgtttaa atcttttctc aggattatca attccaacca attcaataag ctctatggct
    37801 ctcttttttg cctcactttt acttatacct tgatgaatga ttacagcttc tgcaatttgc
    37861 tttcctattg atatagttgg attgagagat gtcatagggt cttgaaatat cattgatata
    37921 ttctttcctc ttatatcttc catctctttt tcagacttct taaccaaatc acttgattta
    37981 agtaaaacct ctccattttt aatatatcca ttgtatggga gtatcctcat caaactctta
    38041 cacagtacag atttcccaca accagattct ccaactatag ccaatgtctc accttttttt
    38101 agattaaaag atacatttct tacagcctga acttctcctt cttctacttt aaaacttaca
    38161 gatagattat taacctccaa taaatgttcc aaaaaccatc aacccctatg ctattcaaac
    38221 cttagggata tatttttatc cctaaggttt ctaattaatt tcagtattat tcaattgtcc
    38281 agtcagctat gttccagaat atacctacac catgatgacc taaaactgta tcaggtgtta
    38341 atccttttat gtttggtttt ccaacatata ttgcatctat ataagcaata aatgtataag
    38401 gcatatcctt agtcatttct acttggaatt gtttatataa ctttaatttt tcatctttat
    38461 cttctgtttc tcttgctttt tgaagtattt tatctatagt aggattagag taagcactgt
    38521 aatttgcacc tttatctgtt ccaaatactt tatatgtatg gtcatctggg tcaaatggac
    38581 ttccccaacc tattaaatga gcatcttgat tagcccaatc tgtttcagtt acaacaacag
    38641 ctttagcatc aacaccaatt tcttttaact gttgtgcaca tattttagcc atatcaactc
    38701 taacttggtc actctcacct gctgttatct cgaaagctaa cttagtacct tctttttcat
    38761 agattccatc agaacctaat ttccaaccta gcttttcaat ttcttgttta gctttttctg
    38821 gattatattc aaacttttct atatcaggat tattatatgg tcccatttgt aaaggtgaat
    38881 atgctggtac accatgtcct aataatacac tgtcaactat tgcttttcta tctattgcat
    38941 agcttaaagc atttggtaat cctttagctt ttttatcttt aaagaattta gaattaaaat
    39001 tgtataatat acctctatag tcggctgttt tcattatatt tactttaaaa ttcttttcgt
    39061 ctttttcaaa gttagacata tctttaggag ttatttgagc taggtctaat tctcctgatt
    39121 ttaattgcat tgccttagcc ttatcatctg gaacaatctt aaagactact ttatctaatc
    39181 ctggttcttt tacaaaataa tcactattct taacaagtgt tatactttga cctttgtccc
    39241 atttttcaag tttaaatggt ccagtaccta ttggtttttg attaaattca tcagtagcta
    39301 tatccttacc ttccaaagca tgttttggta atactcctac tgttaaataa tcaagcattg
    39361 ctgtatttgg agcttttaaa gtaattttta tagtattatc attaaccaca tcaatttttg
    39421 ttatatcttc ataatttgat gctatctcag aagcattatc tggattcatt atagtttcta
    39481 ttgtaaactt aacatcattt gctgtaaatt tttctccatc atgccactta acatcatctc
    39541 ttaaattaaa agtatatgta tttgttgcct catcaaattt ccagtccttt gctagacaag
    39601 gaaccacctt attattttca tcatgagctg ttaatccatt aaatattaac gaatttattt
    39661 ctccatgttc atatagtgca ggatttatac ttgtatagtc attacttcca taaacaagca
    39721 cctttccatc tttaggcgta tctgccttct tatctttgtc tcctccacta gaacaacctg
    39781 ccattagact aagtatcatt actaaactta aaacttttaa cttctttaat ttcatgatgc
    39841 tccccctttt gctttttata aaatattttt caaagctttg accccattta tttaaataga
    39901 tatttcaaat acctcagtat ttgcttattt aatactcaaa tgctgattta taaattacta
    39961 gattttttat tattattctt tcttatataa ttacctatat ttgttataca caccaatgtg
    40021 gtaaccaaaa atatacccgg aatcagtata atccaccatc tatttgaaag taatgcttcc
    40081 tctgacaaag ataacatact tccccaagaa acaatttcta ttggtaaacc aattcctaaa
    40141 aagctaagtg tcgattcagt accaatagct gcgcctatgt ttgttacaac catgaacatt
    40201 attgatgcca caaaatttgg aagtaaatgt tgctttaata catagaagaa tcctcctccc
    40261 atgctcttag ctgctagtat gtattcgcta ttttttattt gtctaacttc tgttctcact
    40321 atcttagata tattcatcca acttgttatc cctattacta tggacataga tactggattt
    40381 gaatttccaa gtatagcttg tacaaatatt ataattaata ttgaaggtat actaagtatg
    40441 atttctgtaa acctcatcat tgcatcatct acaagttcag atgctgaacc acttatacta
    40501 ccataaacaa ttcctataac agttgatatt acagtggaaa atagtcctat aaataaagat
    40561 atttttcctc cataccatat catagaatat atatctctac ccattgagtc tgttccaaat
    40621 aaaaaagttt tatttggagc taaattagaa cttgctaaat ccatgtatgt tggttcatgt
    40681 gtcattataa aagatgagaa tacacttcca atgactatga ttgataaaat aataattgat
    40741 atatatggta attctttaat ttttttagat aaggttttct ttgtttctat atgttcatct
    40801 tctgctacta aaatataatt ttctcctaca atttcaaaat cactatattg tggcttcatt
    40861 agtatcacct ctatcatatt tcattctagg gtctatttta ttgtttataa tttgagctaa
    40921 catattccca aatactacta aagcccctgt tattaagcat aaaactaata acatattata
    40981 atcatgatac tttgcacttt caaaacaaag tgttcctaac ccaggataag aaaaaacttt
    41041 ttcaactaca taagttcctc ctagtatatg aggtatcgaa atggccatta tactaatata
    41101 tgatggcatt atatttctca ggcaatgctt aaaaacaata gttctattat ttaaaccttt
    41161 tgctttacat aaaagcacat aatcttctct tatttcctct agtaatttat ttcttatcat
    41221 atatgtgtaa taccatagat ggcttaatat aagtactgta agaggtaaga ttagatgtga
    41281 tatcctactt aatatactgg actcttctcc cattgaataa gcaccactac ttggaagtat
    41341 acttaagttt atactaaata taagtatgag tactaaggca acccaaaatg atggaataca
    41401 gttggttatt gttcctaatt tgcatatgat tctatcaatg agcttatctt catgtaatgt
    41461 acaaaatatt cctaacaata aggctagcac aaaggtaagt atatatcctg aaccacctaa
    41521 tattatagtg tttatataga catcatttat aacagaagta acattttgtt tatatttaaa
    41581 tgaaattcca aattcccctt ttgatgcatt tgaaatccat tttatatatt gactgtatat
    41641 tggttcatcc aaaccaagtt ttttcatagc attttctttt tcttgtgtac tcattctttc
    41701 tactccatcc ccatagtaag agattaatgg gtctcctgga gcaagtcttg ccatgtaaaa
    41761 aacaataaaa gataataaaa acattactaa aataaactgc aacaactttt tcagtatatc
    41821 ctttaacaaa ccccaacccc cctttgttgc aataaaaaaa accacataaa agcaaacgta
    41881 aagtaacgtt aaaaccttcg tggttccatt atcattaaac aaaattaaat tttctatatt
    41941 tatctatgag ttaattttag catcatttat taactgtgta aacaaacttt ttaaaaattg
    42001 ttaaaatttc atcaaattat tttatttata cctaaaataa aatttttata ttctattctt
    42061 cattattttc tataaaatta taaaatttta ggttgactat ataagaaaag tatattatat
    42121 tagtttgtat gcaaaccatt taagaggtga ttttattgaa aagtaattat gactgtttta
    42181 gaatagccat gctcttaaaa gaactttatt ctaaaactat gtacacagta gaagaaaatt
    42241 ttaaagaaaa tggattaaca caccaacaga ttatagttat aaaactgata gctcataatc
    42301 aagaacttac aatatcacaa ctatgtgatg aaatgtcttt agctaaaggt acggtttcag
    42361 gcataatcag cagattagaa cagattggat atatagaaaa attcaagaaa tctaatgata
    42421 aaagaaatac atacgttaag tttacaacaa caggatttga atttgccaca aattttaaaa
    42481 ttaaaatgca agaaagtttt gatgatattt ttaaaaattg tgatgaaaac gaattgagtg
    42541 acttagtaaa aaatcttaga aatatattgg caaaagtaaa ggagagataa ttatgaatta
    42601 taaattaata cttgcaatag tatttataac atcagcttta attttctaca ctataggtgt
    42661 atttggagaa agaaaggcaa aaattttaaa aaagaaacat gtaattatat tttggcttgg
    42721 ttttatattt gatactttag gaacatttac aatgagtaac atagccaaca gccatacttt
    42781 tgaagtaaaa tctgctttat cacaaaacct tcatagtatt acaggtcttc ttgcaattgt
    42841 gcttatgctt tttcatgcaa gttgggctac ttttgtccta tacaaagatg atgaggaaaa
    42901 gaaaaaattc tttcataagt ttagtatagt tgtatggact atatggttag ttccatattt
    42961 tataggtatg tttattggta tggctggata gtaaaataaa aagtgtgtaa gaaatactgt
    43021 aggtaaattt gtataagaca aatttatcta catccttctt tcacactttt acatatttat
    43081 ttataatact ccattatttc tttcatgttt cttaatacct atatagaata tttaattgtt
    43141 tctatagtat tttattattt tctcacactt tttcatatat atattgtttt actatttctt
    43201 catatgtata tatgaaatat tccattattt ctataaatgt tttattatct ttctcatact
    43261 ttttcatata tatattgctt cactattttt tcttatttct tcatatacat atgaaatatt
    43321 tcattatttc tataatgttt tattatcttt ctcatacttt ttcatatata ttgcttcact
    43381 atttttttta cttctttatt aaatacttat gtataacata catttaataa acgctaacta
    43441 ttaaacacct aatacttgag ttactcctgg aacttcactc accaaaacat tttcaataat
    43501 agctttgatt gtcatagtca ctcctggaca cccactacat gccccttgta gtctaactaa
    43561 aaccacacca ttttcattta catctataag ctctacatct ccaccatctc tttgtaatac
    43621 tggttttatc ttttcctcaa gcactttttc aactttttct ctcatagcta ttccccccag
    43681 aaatatttta ttagcaaaat tataccaatg gtttaaattt ttgtccatct aatgatttat
    43741 caaattcaat ttttgcttca tcaataattt tagtatccat aaatacatca taagcactac
    43801 aagccagtac tttagctgaa tttatcatag cagaaaatcc tatatttgaa cctgctgatg
    43861 aacatgactg ccatgtatga cttgcaattc caacaggcca agctgccatt gcaaattgag
    43921 ccactggtat tacataactt acatctccaa catcagtaga accagctagt cctttatctt
    43981 tgtcaccgtc aactatttcc ttgtgtatat agctttctac aatagattta tcattttgta
    44041 atgatgttgc tacacctaat ctttcttctc tagtaagagt atcacacaac ttttttgcaa
    44101 attcttcttc ttcaggagta tttttagggc aaccaacaaa aaccatattg tcataaacta
    44161 aatcagtcaa acattggttt ggtatatagt catatattcc atctgtaacc ttatactcca
    44221 tttcagtttc tgtcatcatt gctgctcctt gagctacttt tattaatcta tcaagaacgt
    44281 gttctgcatc ctttgctttt ttacctctaa taaagtacca actttcagca aatccaggaa
    44341 ctacattagg tcttccacca ccattagtta taacatagtg cattcttata gagtcaataa
    44401 catgttctct caaataatta gctccaacat tcataatttc aacagcatca agtgcgcttc
    44461 taccattatg aggagcttga gctgcatggg ctgttatccc tttaaattta aattttacag
    44521 ataagtttgc cagacttcca cctctccaag gtgcatttat atcaaaagga tgccatgtaa
    44581 atgcacaatc tacatcatca aaacagccat ttatacacat aactgtcttt cctccacctt
    44641 cttcttcagc aggacaacca aaatatttta ttgttccatt aaatttattt tcttctatta
    44701 atttttttat agaaacaact gctcctacac ctgctacacc caacaggttg tgcccacatc
    44761 catgtccagc ttttccttct accaatggct ttctttctgc acttacacat tgtgatagct
    44821 ctggtaaagc atcatattct ccaagtatgc caatcacagg tttaccctct ccaaaacttg
    44881 ctataaatcc agtaggtaaa ttttctactt cttcaatttt aaatcctttt gactttaggt
    44941 attctttttg aatgctactt gcatactttt cttcaaaggc taattctgga ttttcccata
    45001 ttttcttaga taaatcaatt aattcttctc ttatttcttc aacattattt atgatatact
    45061 ctttcataat tttcctccaa atatatgtat ttttgatatg ctttacagat tatattatat
    45121 actaacattc tatttattca caattttttg ttaattaatt ttattcatat gctcttctat
    45181 ggagtatatc ttatcttcac tttgcctctt cataaattta atgtactcta tcttccataa
    45241 agtagtttca gttttctcat ttaacataaa ttctaatata ttaatttctc tcattctaat
    45301 atcttcataa aatactacac tacccaatat tgccaattct aattcactta atgatgcaaa
    45361 caacattaaa tactcttctc caaataaaca ttcagattca agaatatcga taaagtcttt
    45421 tttagcattg atattttcct ttattattct tattttttca attatagatg tactatctaa
    45481 tatctcattg aatatctctc taaacgattc atcatccaat ttactttcat catcaacaat
    45541 ataatcttct aagtgttcct ttttattttt actcacagtt accatacttt taaaagtgtt
    45601 actttttatt gagcttagca cagattcaat aaatatcttt tcatattttt taatatatct
    45661 tattacatct tcatcttcta tgcttaatct ttttattaat acttcaattg cttccataag
    45721 tagtaaagtt atttttttat ttattctaat ttctctgtta atttcttcaa aatcattata
    45781 atccaaatta ctatctactt cagtgttaaa actatcatct acttcaatca attcaattat
    45841 attactttct tcagagtcta taactttatc ttcagtaata ttattgtaca tatttttaaa
    45901 ttgtttttct aaaaattcat actcatattt tgaaatttct aaattagtca cttcatttcc
    45961 taaaatagta gaaaaaatac aattattcat aataagttca aataaattta caagtataac
    46021 atcacaatct attttataag tcatcccata gtcataaaat aatttttctc tatctttttt
    46081 cttaaatagg ttacaaaatc tattttctat atctatactc tcaatataat tcttcacata
    46141 ataaataccc ttaacatcca tatcatctag tgccaatgga taatctatac ttactggaac
    46201 gtcctgagct tcaaatttta caatataact tttaaagaaa cttgataact ccatcaaggt
    46261 atcattatat gctattgaat tagtatccaa ttttctactc atcattagtt tataaaaatc
    46321 ttttagccta actaactctt cctctaatat ttcaatgcct ccaaggtaca cttttttaac
    46381 attcttagca gtcaactcca caactctttt ttctatatct ccaagcttat ttatatatgc
    46441 atcaatagca taccatattg aaatcaacag tttttcggca acttctgttt ttactgatgt
    46501 gctttgacca tttgtatatt ttttaatcaa gtccataagt attagagata cttcttgttg
    46561 tatattatat acttctcttt catctatcac tttacaattt agacattcct taagtagaga
    46621 tatggaatat tggttcttta ttaaattatt ttcgtttata ttaatattac ttaaattatt
    46681 taacatacaa aatctctcct atcatatatt aaacttctcc aaatttaaat ttctttgcaa
    46741 attcgtctgc ttctcctctt acattgtcca tattgcctga aaatttttca taaaattcac
    46801 ccagtatttc tataatctca tcatcacata tcttgtcatc agtttcattt tttaaataat
    46861 aaaaaatttc ttgcatatca ttaatagcct ctaaataatt gtccacattt gtatattgtg
    46921 atgtatatat attttctatt aactgttttg taacttttat atctaattct attcttccat
    46981 acccctttaa agtattatct ctcgaattta ttatatcttt tacatcagat tcagaaagag
    47041 ctagaccata atctccagat tctatattag tttcaagcag ttcatttctt tctatttcct
    47101 ttaaattctg atttatagaa ctcaaaataa taggtgatat catttttaaa ttctcctttt
    47161 ttattttttc cattgacttt ttttgttttt tatgctatac ttaaattaat gtatattatt
    47221 ttaccaacca cttataatag tagtgttaaa agtggttttt gtcaactcaa aattactatc
    47281 tcaattaaac ttttcaattt tctcaacaaa aaaataccat catttagata tataattttc
    47341 tataacaact tttaattcag tagttattta ctaaaatcta aacaatgata tatttattaa
    47401 ttttatttat cttttttggc tctacttcta cttttcttta catttgagca atttctacaa
    47461 gaaggtgaac agtattgaga tttagaattt gtaggaatat aaattttacc acagtacttg
    47521 catttattta aagaagaagg ttcacttgta attgcaaagg catagatagt ctcaatagct
    47581 gttttcaaag aatcaaactc ccatgcaata attggtttat ctaattggct tatagaaaat
    47641 cctatctttt gaggattaaa ccctccagac ataatagtaa cactttcagt taatagatta
    47701 gatgtatttt tatatacaca aatttgatta aaatgcttac acatatcttt agcaaaactt
    47761 acaatccaat ctagttgttc agtgtagaac tttgaaaata ctaaatctaa aatcaatggt
    47821 ctctttccaa aaaactttgg agattcttct ctctttgata catctatacc ccttctatac
    47881 tttttaaaat acacatcttc atcacttgca aatggtataa acatgtttac atattcatct
    47941 gtactcaata tattctcttt tgtaatataa ttcttttcaa tcatcagtac tctttcttct
    48001 ccaactatat ctctattata tacacttgaa tatattaaac ccaataatcc atactttttt
    48061 acaaattcaa gtacttcttt ctttagtttc atttcttttg tctcttttga tatatcttgt
    48121 aatgcctctt gtcctatgcg aattatatct actattatat catctgctac atcaaatggg
    48181 ttatacatgg taaacacagc atcttctgtt ggaactatat ataattcatc ttcttcagta
    48241 attttatatt cataatcact atacctaatc caatcacttg caaaattccc tattaattct
    48301 atttttttat tcataataat cattcacacc tttcaatgta atatataact tcatattact
    48361 attacacttt tagtttattc catattttct acactgtcaa ctattctttt tatattttta
    48421 gcatattaaa atttataata gcctttataa tggattttta cagctaaatt tcttgtttat
    48481 tgatgactaa ttcataatta aatttataaa aactatttac atataaaatt aatctcttta
    48541 taattgatat gtaatatatt tttacactta catattacat atcaattata aagagaggta
    48601 tctaaaatca tggatagaaa acgtgaatta aaacaattat acaaagaaat gaaatttgac
    48661 acaggtgtat tcataataaa aaatgatatt actaaaaaga tttaccttgg aaaaagtaat
    48721 gacataaaaa gcaaatttaa ctctctcaaa tttcagcttg gtgctggctc atgtatgata
    48781 aaagaattaa ataatgaatg gaaaaaatat ggtgaaaaag catttacatt tgaagtttta
    48841 gaacttataa aacatgatga taacaaaaca gagaaagact atttagaaga actagatatt
    48901 ttagagatgg tttggttaga aaaattaaag gaagataata cttatgaaat ttattccata
    48961 taaaaaataa tataatataa gaaaagtaga tagtgtctca aaatagacat ttagttcata
    49021 agatactttt ttatataaaa taaagtatct tttcataatt ttaacaatga aaaagaggct
    49081 tatctccatt tgatagcctc ttcccatata ttttatacca ttataaaatg aacaatctac
    49141 taattttcaa tgtatatatt cattttacta ataacactcc attacttctt tacagcatcc
    49201 aaacattgct ctataatact cttatcactt atacctattg ctgttacttt actagctcca
    49261 cttaatatac tcttatcact tttatttgaa actaaaacaa caggagcatt ttttgcaagt
    49321 ggtgatgcaa ctaaagcata aactaaatca tctccacttg ttatatagaa ctcttttgct
    49381 ccattataga acttttcaat aacattttta ttagtttgat atctatcaac accaccaatt
    49441 ctagttgctc tatatctgct cactatgtaa tcacttaatg tagactctcc tccaatagca
    49501 tatactggaa caggagaaac tccaaaccat gggtctaagt ctgtgtcttc ttctgctgaa
    49561 ggtatatctt ttgtcaatat tataggagct ccatctctat aagcaacaga tgcaacactt
    49621 actgcatcag cttcatcctt aaatccattt actaaaaaca tcttatcact gtttttaatt
    49681 ttttctattt cacctgcaat tttataactt gtatctactc tatctacacc atcaattctt
    49741 ataacttgca ttcttctcat aagtaacatt ttttctacat ctttacttat agaattttct
    49801 ccacctatta catatatctt agtaactcta ttcagtcttt gaagtgttgc ttctggtata
    49861 tcatccttat tagttaataa aatagctgca ttatttactc ctgcaagacc acttgcagca
    49921 atcccatcta ccattgtaga gtctgcattg ataagaactg ctgttgtaaa atcttgctta
    49981 tctgaaataa gcccagctgt ttcatattta tctactcctt gaatattttc aatcttatct
    50041 agtgcgttta ttgatgttgg aaaactaaca cttaacagta atgctgaaat acctaacgcc
    50101 aatacctttt tactaatcct cataaattac ctccctaaaa caaatatatt tagtattagt
    50161 ataatataaa atcatttaaa aatagtgtaa aaatagttac acttttttat aatttaaata
    50221 attttagact aaacacaatt catccattaa aataacttca tttattctat atgctaagcc
    50281 atcccacgtt ttttttgaca tatctacaga tgttttctta tttgagttat tcaataaaga
    50341 ttgtatctta gaatctattg cattatacaa attattttca aaatcatata actcttcatc
    50401 ttttggaata ccttctttct ccataaaagg tagagaaaca tattctatct ttccagaatt
    50461 attaatctca ctaccaatcc actctttaac accaagaata tcagtagtga ttacatctgt
    50521 gccacaagat aaagcttcta aaactacaac tggtaatccc tcataaaatg atggtaacac
    50581 aaatatttgt gacctgttga atagctcagc taaatctctc tgttctaact ttcctaggaa
    50641 attcatttta aatggagact tacttgccag tttaactatc tcattatatg attcgatatc
    50701 gcttccagta cctgcaaaat tgacttctat taaatcttta ctatatttta atttagatat
    50761 agcttttata aatggaatca gtccctttga tttacatatc ttacctgcaa atactatttt
    50821 tattttatca tcctttattt tataattttt attataaaat atatcatcat tataaccact
    50881 accaattaca actactttac tttcacttac tccaaaagtc tttataatat catatttctg
    50941 attttcatga agagcaaata ttaaatctaa tttccttata tttgctatta tgtattcttt
    51001 ctctaaatca atggtattta actgtcttaa acaagttcca tgacaaatag acataacctt
    51061 tatatctttt accatttccc taacaaatgc agttaagagg tacaaatgat gacatattat
    51121 aagttctggt ttaaaatcat tcatagcctt atctatattt actttaaatt gatatttcaa
    51181 tctatttatc atgtctatat ttaaatcttt atatcttgta ctttcatatg gcatagaatc
    51241 actcatacct acaacaggaa aatttaactc cccacaatta tactttactg gataaaaact
    51301 tacttcactt ggaaaacaat ttacatcatc atttacatct atacctgcaa ttacagcttg
    51361 cttatgaccg attttttcga acccttttat cataccagac aaatatatac cactacctgt
    51421 actatttggt ttttgtgtta ttatatgaag aattttcact tttcacttgc ctcctttcta
    51481 aaattaaata gttttataca gtctaatcat tatatatatc taaatataaa caagatgaat
    51541 catcttttac tttaaatctt ggcactttaa ccgctttata gtcattatct tcaaaatccc
    51601 ttactttatt atgtatatat cctataccaa atttttctgc tatacgtatc aattcttctt
    51661 cttttattag attatatcta tcacatgcac ttgtaaaacc atcactcgtt agcatcaatt
    51721 gaaaatcttt ttttatttca atgtatccat atatagaatt ttccacagct tcctcatcaa
    51781 aatccaatat ccaatagccc tcttttgtat ttttcttcaa tctattgctt actattgtat
    51841 ccataacact agttctaatc tcatcaaaag ccatctcttc caagttagaa agtttactca
    51901 tttcatcaaa tacagtatta tcaaatttac aaatactcct atcttttata actttggaat
    51961 ctccattttt aataaacaaa gcacaatctc ctaataaaaa atactctact ttattttcat
    52021 gaaattttac aacaactata gaactagatg gtaaatctaa tttttcaacc ttaaacccat
    52081 ttaatcttag ttcatactct ttttttactt ctattattcc agtattaata atactcttta
    52141 atgattcttc tttatttata tttttatata aatacctatt ccaccactga acataccacc
    52201 ttgcgtcact ttcagttgac actaaatttt ttccattaag tcctgtagca ccatctaaaa
    52261 cccatgcccc aaatggattt ataccgacta catcttcatt aaatttagct gttccttgat
    52321 tacataatag gctatagttt cttatattta aagccatatc aacctccaaa ttgaatatct
    52381 aaaaataaag ttctatttaa aattatacag caaataaaaa aatctacaac aaaacttgtt
    52441 gtagattttt acttaatcta tattatcttt atactttcag tattttaatg atggaataat
    52501 ctatttttag taaatgccat gactatgtta tacttattac aagttaatat aacattatca
    52561 tcacgaatag aaccacctgg ttgtgctata aaacttaccc cacttctttt tgcacgttct
    52621 atattatctc caaatgggaa aaatgcatct gaaccaagtg ctactcctgt taaagtttta
    52681 agccatgctc tttttccttc tccagttaga ggctctggtt tttcttcaaa aaagttttgc
    52741 catatgccat cagcaagcac atccatataa tcatcagaaa gatatacatc aatagtgtta
    52801 tctctatctg gacgacctat atccttttta aattttaagt ttaatacttt aggatgttga
    52861 cgaagatacc aagtatcagc tttgttacct gcaagtctag tacaatgaat acgtgattgt
    52921 tgacctgcac ctacccctat tacttgtcca tctttagcat aacaaacaga atttgattgt
    52981 gtatatttta atgtaataag agctataatt aaatcacgtt ttgcactatc tgtaaaaatt
    53041 ttattatcag ttggaatatc ttttaatagg tcttcattta ttaatatttc atttctacct
    53101 tgttcaaaag taattccata aacatccttt gtttcaatag gttcaggagt ataattttca
    53161 tctattttta caatattata gttaccttta cgctttcctt ttaatatttc aagggcttca
    53221 tctgtatatc ctggagctat tataccatca gaaacctctc ttgctataat agttgcagtc
    53281 tccttatcac atacatctga aagtgctata aaatcgccat aagaagacat tctatctgct
    53341 cctcttgcca ttgcataagc acaagctaat ggagaaagct ctaaatcatc aacaaaatat
    53401 atttgcttta aagtatctga taaaggtacc cctactgctg ctcctgctgg acttacatgt
    53461 ttaaatgaag ttgctgctgg aagacctgta gcttctttta attccttcac aagttgccaa
    53521 ctattaaatg catctaaaaa atttatgtat ccaggttttc catttaatac ctctatagga
    53581 agttctccat tcttcatata aatctttgat ggtttttgat ttggattaca gccatacttt
    53641 aattctagtt ctcttgccat atactcatcc ctctctataa taaattaatc ataagtttga
    53701 ttaatcctat attaattaaa ttattcgtac taataaaatt atatggcata tttatccatt
    53761 aatcaactat attttttaaa actcctattc cttcgacttt acattcaact atatcgccat
    53821 gctttaaata tacttgagga ttcatcccca tagcaacccc tgctggagtt ccagttgaaa
    53881 ttatatctcc tggctttaga gtcattcctc ttgataaatc atttattata gtaggtatat
    53941 caaatataaa gtactctgta ttagaatctt gtcttacttc tccatttact acactactta
    54001 tatctaattt taaaggatgt tcaaattctt ctttatgtac tatacaaggt cccatagatg
    54061 tatgtgtgtc taagcttttt cctctaaacc attgaacatg tttatcttga agtgctcttt
    54121 cacttatatc atttactatt gtatatccaa atatatattc ataagcatct tcttttgata
    54181 tatttatacc ttctttacct atgattactg caagttctga ttcatagtcc aacttctcta
    54241 ccaaatctcc atgtaagctt atcttatcat ccactccaat tattttgtct gctctcttag
    54301 aaaaataaat tggataatct ggcataacta cgttttttat aactccatct gggatttcat
    54361 tgacatggtc tttatagttt agacctaaac atataatatc ttttttaggt cttacaattg
    54421 gggaacataa tttaacttct tctaacttat aacactttgc gttttcaaat gaattgtttt
    54481 ttattttttc taaatctcct gtagatacgt tttcaataaa atcattcata tcagtatata
    54541 atttacttaa tcctaaacta ttaatttcat atatactatt tgtttctgaa ttaaatacac
    54601 ctattttttc ttcattgcta ctacaaaaag tcacaaattt catttttatt cctccattca
    54661 ataagttgat taatattatt taatttttat tagtttatat aa
//
LOCUS       DAEHWM010000017        54691 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.018, whole genome shotgun sequence.
ACCESSION   DAEHWM010000017 DAEHWM010000000
VERSION     DAEHWM010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 54691)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 54691)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..54691
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.018"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            77..1057
                     /locus_tag="KNP36_001044"
     CDS             77..1057
                     /locus_tag="KNP36_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBF0872932.1"
                     /translation="MNLKLIWINILNPVFIKNEIKRKKIQIIIFFFINFGLTYSLGLL
                     LYYNKFIDPENFASFMMILPLSSVAIAKFYTEGLNNDMYEFYSLIILFFLIYSLLIVL
                     KLLNLINNNEFIIINLILTFISSLSIIIYSSNKKNLYPVKNIKLGSLLIIYFMISVIV
                     PTSFILILQGAQPNYSGIIKFIFTPITSLTTIYIFFSEEYAWRGFLQNIFFDKFGKKL
                     GVIILGMCWSLWHLPLIFTLYTPEAPILGIILRSIHIVGISIFLGYLYIKTKNIWFCA
                     IIHVLNNSAFLITNSKESTITYHDILIVSMVVLIFYVPFLFTKEYKNNLE"
     gene            complement(1156..2118)
                     /locus_tag="KNP36_001045"
     CDS             complement(1156..2118)
                     /locus_tag="KNP36_001045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBF0872933.1"
                     /translation="MNKSWSNLIIKNKDKKVRSGWIIIAVMATFYILQYYLSMILVEI
                     IRKILVATGDINLKTNYFSEYANWLNDVGLQIVFQILTDSLMIIIPIIVWRFIMKNPI
                     SEMGLHSYRIKKKEGYVGMLLGIFNCTVIFIITITIGGGHVTSWVPKISPLTVSWILV
                     FILVAFAEEILNRGFFMAVLRRCKNIYFIMIVPSVIFGLIHIWNPDVTFLSVINIIII
                     GILFSYMFIKSSNIWMCIGYHFAWNVFQGIIYGMPVSGLQVPGIITTQITHGNLLNGG
                     MFGIEGGILTTFVNLLSFIFVWYYYRDSKYDFVSDKVNVTNIKN"
     gene            complement(2434..3384)
                     /gene="hpdA"
                     /locus_tag="KNP36_001046"
     CDS             complement(2434..3384)
                     /gene="hpdA"
                     /locus_tag="KNP36_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase activase"
                     /protein_id="HBF0872934.1"
                     /translation="MSSQKQLEGMIFDVQSFSVHDGPGCRTTVFLNGCPLSCKWCANP
                     ESWTVRPHMMFSELSCQYENGCTVCHGKCKNGALSFNLDNKPVIDWNICKDCESFECV
                     NSCYYNAFKLCAKPYTVDELVQVIKRDSNNWRSNGGVTFSGGEPLLQHEFLHEVLLKC
                     HEVNIHTAIETSACVSNEVFNKIFNDIDFAFIDIKHMDREKHKEQTGVYNDLILENIS
                     NLANSDWNGRLVLRVPVISGFNDSVENISDIISFMHKNNLVEINLLPFHRLGESKWIQ
                     LGKEYEYSDKGDVDEGHLEELQDIFLDNGIACYVGHETAF"
     gene            complement(3377..3634)
                     /gene="hpdC"
                     /locus_tag="KNP36_001047"
     CDS             complement(3377..3634)
                     /gene="hpdC"
                     /locus_tag="KNP36_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase small
                     subunit"
                     /protein_id="HBF0872935.1"
                     /translation="MRKHSDCMNFCAVDATKGICRLSKQMINLDDAACPEIKVMPKCK
                     NCKNFVEANDEGIGKCVGLEKEDWVYSTLNAITCEGHVFNE"
     gene            complement(3638..6346)
                     /gene="hpdB"
                     /locus_tag="KNP36_001048"
     CDS             complement(3638..6346)
                     /gene="hpdB"
                     /locus_tag="KNP36_001048"
                     /EC_number="4.1.1.83"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxyphenylacetate decarboxylase large
                     subunit"
                     /protein_id="HBF0872936.1"
                     /translation="MSQSKEDKIRSILEAKNIKSNFQNKENLSEFNEKKASKRAEDLL
                     DVYYNTLSTADMEFPYWYNREYRKSDGDIPVVRRAKALKAAFSHMTPNIIPGEKIVMQ
                     KTRHYRGSFPMPWVSESFFVAQGEQMREEAKKLASNTADELTKFGSGGGNVTESFGNV
                     VSIAGKFGMRKEEVPVLVKMAKEWVGKSVEDLGFHYEKMMPDYDLKENLMSTLICMFD
                     SGYTLPQGREVINYFYPLNYGLDGIIEMAKECKKAVAGNASGDGLIGMDRLYFYEAVI
                     QVIEGLQTWILNYAKHAKYLESIETDLEAKKEYSDLVEILEHIAHKQPRTFREALQLT
                     YTIHIASVNEDAISGMSIGRFGQILYPWYEQDIEKGLITKEEVIELLELYRIKITCID
                     CFASAGVNGGVLSGNTFNTLSIGGLKEDGSTGANELEELLLEASMRCRTPQPSLTMLY
                     DEKLPEDFLMKAAECTKLGSGYPAWVNNSNGTTFMMKQFADEGMTVEEARAFALGGCL
                     ETSPGCWKQLTLNGKTYSIAGGAGQSAGSGVHFIANPKILELVLMNGKDYRMNIQVFE
                     PHNKPLDTYEEVIEVFKDYYKQAINVLERANNIELDIWRKFDTSIINSLLKPDCLDKG
                     QHIGNMGYRYNATLNVETCGTVTMVNSFAALKKLVYDDKAFTIEEMKDAILNNFGFKD
                     ALEVGNYSMADQVKVDKTGKYDAIYKACLDAPKYGNNDLYADNILKNYEVWLSKVCEE
                     AQSLYAKKMYPCQISVSTHGPQGAATLATPDGRLSGTTYSDGSVSAYAGTDKNGVYAL
                     FESATIWDQAVVQNSQMNLKLHPTTIKGQQGTKKLLDLTRSYLRKGGFHIQYNVVDSE
                     TLKDAQKNPDNYRQLMVRVAGFTQYWCELGKPIQDEVIARTEYEGV"
     gene            complement(6643..7659)
                     /gene="tsaD"
                     /locus_tag="KNP36_001049"
     CDS             complement(6643..7659)
                     /gene="tsaD"
                     /locus_tag="KNP36_001049"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HBF0872937.1"
                     /translation="MSDIITLAIESSCDETAASVLKNGREVLSNIISTQIETHKKFGG
                     VVPEVASRKHVENIDIVVQEALDKANIGFNDIDHIAVTYGPGLVGALLVGLSYAKALA
                     YTLNIPLVGVNHIEGHLSANYIEHKDLKPPFITLIVSGGHTHLVEVKDYGKYEILGKT
                     RDDASGEAFDKISRAMNLGYPGGPIIDNLAKNGNKHAIEFPRAYLEEDSYDFSFSGLK
                     SSVLNYLNGKRMKNEEIVVEDVAASFQEAVVEVLSTKALKAVKDKGYNIITLSGGVAS
                     NSGLRAKITELAKDNGITVKYPPLILCTDNAAMIGCAGYYNFINGKTHDMSLNAVPNL
                     KINQ"
     gene            complement(7665..8141)
                     /gene="rimI"
                     /locus_tag="KNP36_001050"
     CDS             complement(7665..8141)
                     /gene="rimI"
                     /locus_tag="KNP36_001050"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HBF0872938.1"
                     /translation="MEDNTKLIVDDIKIEEMTTEDIDEVFEVEKNCFEDYWSKESFRK
                     ELSNEVARYIVAKLNGKIVGYVGIWLILDEGHINNVAVHSDYRGKKIGDKLIKGIVDL
                     CKDNNIASMTLEVRASNKIAQNLYRKYGFKMGGIRKEYYSDNKEDAIIMWNQLKEV"
     gene            complement(8131..8847)
                     /gene="tsaB"
                     /locus_tag="KNP36_001051"
     CDS             complement(8131..8847)
                     /gene="tsaB"
                     /locus_tag="KNP36_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HBF0872939.1"
                     /translation="MKILGMDTSSMAASVAVVEDDNLICEFTVNNKKTHSQKLMPMIE
                     NMLSMSDLSIKDMDLLAVCIGPGSFTGLRIGMATVKAMAHVNNIPIIAVNSLESLANN
                     INFCDRKICCILDAQKNQVYSAKYKFENGEMIELDGVDVVEFDALVDEIVSTNEEFII
                     VGEAVYKYKDKLENIKNIKIPSPANNVSNAGSLCSLALNKYNKNIDVHTCYTINPMYI
                     RKSQAEVQYDEKMKRLNNGR"
     gene            complement(8847..9299)
                     /gene="tsaE"
                     /locus_tag="KNP36_001052"
     CDS             complement(8847..9299)
                     /gene="tsaE"
                     /locus_tag="KNP36_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HBF0872940.1"
                     /translation="MAKIYLENENKTREIGYKLGKLLKEGSVICLVGDLGAGKTTMTQ
                     SLADSLGIEDYITSPTFTIINEYEGKIPLYHFDVYRIGSSDEMYDIGYDEYVNSNGIC
                     IIEWANLIEDILPKEYLNIELRYKDEGREMILTPKGEFYKEIVEELIK"
     gene            complement(9438..10478)
                     /locus_tag="KNP36_001053"
     CDS             complement(9438..10478)
                     /locus_tag="KNP36_001053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBF0872941.1"
                     /translation="MHLSKKIKKLFLDDKGYYFNSNWKDIHIGIYDTKLGDSLKYITN
                     EYIENMERVKYDYRELKNIENQTDGMCILAIRQNYKALEYVKNQTEELCLEAIKYNYK
                     ALEYVKEQTEYLCLEAIKKDCNALKYVRNKTEGLIIKAISHSSNIDVVSILKALETQT
                     RRICLEAIKKDGRCLAYVREQSEELCIEAIKQNYKALKYVKNQTEKMCIESVRQNGMA
                     LQYVNKQTDKICIEAVKQDGRSIQFVNNKTEEICINAIRYLNKKYNIKDVLSYIDKYT
                     EDICIEIVRQNGKMLMYIKNQTEKMCIEAVKENYKSLKYVKEQSERICKEALKQNHKA
                     KEYVKIAIDDCI"
     gene            complement(10807..11412)
                     /locus_tag="KNP36_001054"
     CDS             complement(10807..11412)
                     /locus_tag="KNP36_001054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBF0872942.1"
                     /translation="MQNTAKRGNMISTRTLVVMSILSAISYLLMFIQAPIPGIFPDFL
                     KIDLSDIPAIFGGMSLGPLVGFGIVVVKNVLQAITATTTGGIGEFANILIGGSYVMIL
                     CYSYKRSGDLKGVLIGFVLGTISMTIIGSLVNYFVMLPLYGQLMGLDAIIGLGSAINP
                     QVHDLFTFVIWMIAPFNVLKAVIISLVTLPLYKKMGNIIKK"
     regulatory      complement(11537..11654)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            complement(11714..12880)
                     /locus_tag="KNP36_001055"
     CDS             complement(11714..12880)
                     /locus_tag="KNP36_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0872943.1"
                     /translation="MIFIKNGKINTITNGIIHGDILIDEGKIIEIGEDLIAPLDVEVI
                     DASNKLVFPGFIDAHTHLGLWEDGIGFEGADGNEETDPITPQLNPIDGINPMDRTFKE
                     AFEGGITSVCTTPGSANVMGGQCIAIKTCGKRIDKMVIKNPVASKIAFGENPKSCYGQ
                     DDKSPQTRMAIAALLRENLKKAEEYLEDIDMYESHDDEDCEKPEYDIKMESLIPVLRR
                     EIPFKAHAHRADDMFTAIRIAKEFNLKLTLDHCTEGHLIVDELVEEGFPVIVGPSLSE
                     RSKFELRNLTFNTAGILSNAGLDVCIMTDHPVIPVQYLPICAGIAVKHGMKEEKAIES
                     ITINPAKALGIEDRVGSIEVGKDADLVIWDNSPLEIQSNVLYTIINGKVVYEKK"
     gene            complement(13028..15169)
                     /locus_tag="KNP36_001056"
     CDS             complement(13028..15169)
                     /locus_tag="KNP36_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HBF0872944.1"
                     /translation="MDINQILKKEFNLRDEQINNTLKLIDEGNTIPFIARYRKEMTGE
                     MSDVTLREFYEKLMYLRNLQSRKDDVVRLIDEQGKLTDEITQNIEKAKTLQEVEDIYA
                     PYKQKKRTRATIAKEKGLENLALSILENNLDNIEIEAKNYLDEEKEVLSIEDALKGAR
                     DIIAELVSDDAKIRKYIRELALREGMIVSKSATDEKSVYDMYYDYSEAVKSMAPHRVL
                     AINRGEKESFLKVKLEINNDKVLNYIINEYVNDKNFKNKEEIVSSIEDSYKRLIFPSI
                     EREIRNHLTEIAQERAISVFGKNVKSLLLQPPVKDKVVMGFDPAFRTGCKIAVVDKNG
                     KLLDYTTVYPTDPQNDVEGAKKVLKGLIEKYDIDIISIGNGTASRESETFVSEMIKEI
                     DSEVQYVIVSEAGASVYSASELANEEHPDINVSIRGAISIARRLQDPLAELVKIDPKS
                     IGVGQYQHDLNKKRLEEVLDGVVEDSVNSVGVDLNTASYSLLEHVAGISKAIAKNIIA
                     YREENGDFTSRAQLKKVKRLGPQAFTQCAGFMRILEGKNPLDNTGVHPESYDICKKMI
                     EIIGYSLDDVKNKNIGEIDEKIKEIGLRELSEKLEVGQVTLKDIIAEIKKPGRDPREE
                     GIKPILRTDVLKIEDIQEGMTLKGTIRNVVDFGAFVDIGIKNDGLVHKSEMSNSFVKD
                     PMSIVTVGDIVDVKVIGIDLNKKRVALSMKK"
     gene            complement(15313..16420)
                     /gene="prfB"
                     /locus_tag="KNP36_001057"
     CDS             complement(join(15313..16344,16346..16420))
                     /gene="prfB"
                     /locus_tag="KNP36_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_153309863.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HBF0872945.1"
                     /translation="MLKLQEYRHSMEQMASNLEELRVSLDIASLMKNIQINEEKMNQQ
                     DFWNDNEVAQRVLQENKSLKETLEEYESLKSLLEDIEVLIEIGLEEDDDSVERDIEKS
                     IESMEEKLSEMKIKTLLNGEYDKNNAILSINAGTGGLDAQDWAQMLLRMYIRWSESKG
                     YKVKLLDIISDPEAGIKTATILVEGTNAYGYLKSEKGVHRLVRISPFDPSGKRHTSFA
                     SIDVTPELDENIEVEINPSDLKIDTYRASGAGGQHVNTTDSAVRITHIPTGVVVQCQN
                     ERSQHLNKDRAMRLLMAKLIELKELEQKEKIEDIQGKYSQITWGSQIRSYVFQPYKLV
                     KDHRTNAEFGNVDSVMNGNIDLFINEYLKMNKIV"
     gene            complement(16435..19110)
                     /gene="secA"
                     /locus_tag="KNP36_001058"
     CDS             complement(16435..19110)
                     /gene="secA"
                     /locus_tag="KNP36_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HBF0872946.1"
                     /translation="MSFMDNLFNMADKKELKKFNKTVDIIDSLEPKFESMADSELKNM
                     TNIFKERLANGESIDDILPEAFAVVREVSKRVLGLRHYRVQMIGGIVLHQGRIAEMKT
                     GEGKTLVATAPVYLNALTGKGVHVVTVNDYLAKRDRDQMAKIYEFLGMSVGVIIHGQN
                     PKVRKEQYDCDITYGTNNEYGFDYLKDNMVIHKEQRVQRGLNYAIVDEVDSILIDEAR
                     TPLIISGPGDKSTHLYSDANTFVLTLKPDDYELEEKDKAVSLTASGIQKAEVYFNVDN
                     ITDISHTELYHHINQALRAHVIMKKDVDYVAKDGEIVIVDEFTGRLMFGRRYSEGLHQ
                     AIEAKEGLKIQRESKTLATVTFQNYFRMYKKLSGMTGTAKTEEEEFKAIYKMDVFQVP
                     TNKLMIREDLPDCVYKSEIGKFNAVAQEIIERHKVNQPILVGTVSIEKSELLSQILKK
                     KGIKHEVLNAKHHDKEAEIIAQAGRLGAVTIATNMAGRGTDIVLGGNPDFLTKREMRR
                     NGFKEEIVNRVDTPIEGIPVKGNEILFEAREEYEKLFEKFKQQTQEEQKQVVEAGGLA
                     IIGTERHESRRIDNQLRGRAGRQGDPGSSRFYIGLDDDLMRLFGSDRISGIVDKIGLE
                     EDMPIEHRILSKSIEGAQKKVEGKNFGIRKHVLQYDDVMNKQREIIYAERKRVLEGED
                     LQEQIQSMTHSIIEEAVTLYTQDKGFDEEGFKEHMYNLFLPKGSIEIPEIEKLNPVEI
                     TEKVYEIAMKIYTSKEEQVGYERMREVERVILLQAVDNHWIDHIDAMDQLRQGIGLRA
                     VGQQDPVIAYKMEGFDMFDEMNKHIKEDTVRYLFNITIETPVERKAVVDVENLSSPSD
                     GTLPTSKTVKKDEKVGRNDLCPCGSGKKYKNCCGR"
     gene            complement(19242..19793)
                     /gene="raiA"
                     /locus_tag="KNP36_001059"
     CDS             complement(19242..19793)
                     /gene="raiA"
                     /locus_tag="KNP36_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HBF0872947.1"
                     /translation="MNIIISGKQIELTDAIKNKIETKLSKLDNYIHPDTDVKVTVSAR
                     KARQKIEVTIATVNGPIIRAEDMQENLYTAIDVVYDKLSKQLKKYKKRLQDKHKDNKS
                     IRFQDAEINLADEQENYGDENQELVIQRRKKFSVKPMSEEEAVLQMELIGHDFYMFKN
                     IDSDEIAVVYKRNNGGYGIIEHE"
     gene            complement(20346..21020)
                     /locus_tag="KNP36_001060"
     CDS             complement(20346..21020)
                     /locus_tag="KNP36_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HBF0872948.1"
                     /translation="MLEIIGMSVEDAKIIEDCGADRIELVSALTEGGLTPSFGLIESV
                     VNSVKIPVNVMIRHHAKSFVYSKEDISIMQKDISVVKEIGANGVVFGVLDKNNSIDEK
                     NLNVLLKCCDNLDVTFHRAIDESNTIDSVKILKDYDKITNILTSGGKGSIVDNIQMIK
                     NMMLSSNHIKILLGGGLNFNNIEKIKELTKASNFHFGTAIRINNSPFEDIDRQKLKQL
                     VNIISR"
     gene            complement(21023..22075)
                     /locus_tag="KNP36_001061"
     CDS             complement(21023..22075)
                     /locus_tag="KNP36_001061"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Sapep family Mn(2+)-dependent dipeptidase"
                     /protein_id="HBF0872949.1"
                     /translation="MNIISNKIDELKEDLLSDIIDIVKIPSVKGESENGFPFGEKVGE
                     ALNKALEISEKLGFKVRNLDNYIGYAEHGDSDDYVCVIGHVDVVHEGDGWKHQPYKGE
                     ETNGRIYGRGVLDNKGPIMSALYGLYAIKELNLKLDKRVRIIFGTNEESGFEDIPYYL
                     EKEKAPIMGFTPDCKYPVVYGEKGMAKIRIKSKINYEEDVYLGFIENMSENVLVTYKE
                     LNIENSDTILDIKVKYDFSYKLKDVLDEIKASFPNSIDIEVISNFNPVYFDKESNLVK
                     KLQLAYERVTSLDGTPVTTNGGTYAKVMPNIVPFGPSFPGQKGIAHNPDEYMDIEDII
                     LNAKIFANAIYELAKE"
     gene            complement(22124..23083)
                     /locus_tag="KNP36_001062"
     CDS             complement(22124..23083)
                     /locus_tag="KNP36_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase"
                     /protein_id="HBF0872950.1"
                     /translation="MWGMIATWRMALEGITEASEHLEKGMEAGDAVELAVRRVEDYPF
                     YKSVGYGGLPNENCEVELDAAFMDGNTLDIGAVAGIRDYSNPVSIARKLSYEKVNNFL
                     VGIGAEDYAHKNGFERKNMLTDRAKLHYKKRKKETLDKGLSPYAGHDTVGMISLDKTG
                     KMCAATSTSGLFMKKRGRIGDSALSGSGFYVDSSIGGATATGLGEDLMKGCISYEIVR
                     LMKEGKHPQEACDIAVNELDKQLIKRRGKAGDLSLVAMNNKGEWGVATNIADFTFSVV
                     TKEESPTVYISNRVDGKTIHKVISNEWMEAYEARIKAPIEVSE"
     gene            complement(23176..23697)
                     /locus_tag="KNP36_001063"
     CDS             complement(23176..23697)
                     /locus_tag="KNP36_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/betaine/sarcosine/D-proline family
                     reductase selenoprotein B"
                     /protein_id="HBF0872951.1"
                     /translation="MKKIVMILDQIQAGAGGKEKSNIPPAGKSSPLGPGVMMEQFLNE
                     SKVIATLFCGDEFFVNNQEEVTSKMIAMVKKLNPDVVICGPSFNYENFSKMSAILSKN
                     INDKTDIPAFAAMSEENIDVINEYKNDICIVKTPKKGGIGLNDSLNNICKLAKAIANK
                     EDITLMKEEFCYQ"
     gene            complement(23708..25042)
                     /gene="celB"
                     /locus_tag="KNP36_001064"
     CDS             complement(23708..25042)
                     /gene="celB"
                     /locus_tag="KNP36_001064"
                     /EC_number="2.7.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIC"
                     /protein_id="HBF0872952.1"
                     /translation="MNRLERILMPLAEKIGKNKLLIAIRDGFLVSSPLLIIGSLFLLV
                     ANFPIKGWNEFVGQIFGPDWAVKLQQPTVATFEVMTLLAVLGIGYSYAKQIDVDPIAS
                     AAVAIVAFFIITPFVIPYTPEGTESVYMVTGIPLGWMGSKGMFVGMITAITSVKLFAA
                     VVKKGWTLKMPDGVPPTVSKSFAALIPSAIVMVVFFLVKIAFEATPYGSIHEFIFKFL
                     QMPLLKLGNSLGAMAIAYIFLHLFWFFGINGSSVVGAVYNPILKILSAENLAAFQAGS
                     KIPNIITGQFQDMFATFGGAGSTLSLVIAMLLICKSKRIKSMGKLSILPGIFGINEPL
                     IFGLPIMLNPILLIPFAIVPTINIIIAYFCMSAGLVPLTNGVQLPWTTPIIFSGFLTT
                     GWQGAVLQLVLLILGIFMYIPFIKMLDKQYLREENETVEEEDDDISFDDLVL"
     gene            complement(25081..25407)
                     /locus_tag="KNP36_001065"
     CDS             complement(25081..25407)
                     /locus_tag="KNP36_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0872953.1"
                     /translation="MKRKVYLFCSFGMSTSLLADKMQKVADEHNLPIEVEAFPIAEID
                     KIVEEKNPDCILLGPQVKYMLKELKPKFEAQGKLIDIINEVDYGTMNGEKVLKLAIKL
                     IKSKQA"
     gene            complement(25431..25739)
                     /locus_tag="KNP36_001066"
     CDS             complement(25431..25739)
                     /locus_tag="KNP36_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBF0872954.1"
                     /translation="MEEIVLKIIIHAGNAKSMLYEALDYAKENDFKKADELIENANEE
                     ILKAHKVQTELIQKEAGGDKSDISILLIHSQDHLMTCMSERNLIKEMIMLRKEIQKLK
                     "
     gene            complement(25880..27793)
                     /locus_tag="KNP36_001067"
     CDS             complement(25880..27793)
                     /locus_tag="KNP36_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0872955.1"
                     /translation="MICLNKRQENLLTTLLLKEEFINVNKIANDFECSERTIRNDCKY
                     IDEWLSTFCNAYIKRKPNIGIKFSGDGTDKILVNQKLRGEVKRVNSELHKQVEILNLL
                     LCNNKKVTLNDLSNKLYINKNIVREEISKLSVALNNYNLNISTKKGSGIYIEGDEKDI
                     RIMLVSFLFKYIDKYRLNIDEIEYFHIVDIIIVKNIMLTIEEDMDIRLTDISFKQLML
                     FLLINIIRIRLGNSLKVSNTKKELKLKMLILDIEDELKSNLSIVLNYEEKLFIESLIL
                     GMNKQINSNNIKKSLYLNEELASYTKKIINLVSEESGINFNNDILLYEQLICHLNVTM
                     HQMKSNVYLENPLLDNIKTKFCFLFTVISSSIEIELKGKQITEDEIGYLTLHFQTSLE
                     RKYSKRESNKKASIVCPFSFGVSMLLKVKIEKRFDNIKIIETLREEDLKRDNFNKTID
                     FIIAFQEYENIQKPIFITTPLFTDEDENKLKEFTNKIKEKDTSYKLMNRLMMSDYLIR
                     ELEHDDIYEAITYLTNLLIEKHYAEKEYLQSIITREKSYPTNVGKGILFPHGDMKYIK
                     QSVLCFARLKTPIKIRNGKDIKIILLLAYKKDDDRKVFRELFKEISNLTEDENMLDIL
                     SKCDIEKVKDILI"
     gene            complement(28125..28907)
                     /locus_tag="KNP36_001068"
     CDS             complement(28125..28907)
                     /locus_tag="KNP36_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HBF0872956.1"
                     /translation="MKICNDNFIKNFKNMINKCLDFIYPENISCIICDKSIKKTNTYS
                     ICKSCFKEMNFIQDGCMKCGKPIIRHSIEKEFIEECSYCFNKDFYFDKSISCIEYNDV
                     TKKMVLGLKYNQKTFMAKYIAQIMKEKLYLENIKFDYILFVPLHKKRLNKRGFNQAQK
                     IAFNLSKIVNIPLLDCISRKKYTRMLYKLNKKERKEELKNVFVVKENVKLINNKNILL
                     IDDIFTTGLTTNEISKLLKLSGANKVFVLTLLTKANDNYIME"
     gene            complement(28910..31129)
                     /locus_tag="KNP36_001069"
     CDS             complement(28910..31129)
                     /locus_tag="KNP36_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HBF0872957.1"
                     /translation="MEKLEGMISEIVFKNEDNGYTIAHLVNENDEIVVVGCMPTLAIG
                     ESIEVEGKWVNHKIYGTQFEVNSFMPVTPSSLEGIYVYLSSGMIHGIGEKMAKRIIDK
                     FGVDTLEVIQNSPEKLQEVEGIGSKKVKQIVKSYEEDRELRNIIIQLSPFGITPNYCL
                     KIYKKYKSSAIEVINKNPYQLAEDIRGIGFKVADSIASKIGIDKNSKDRICQGILYTL
                     NKSLSNGHTYLPEHVLIQDSEKLLELNGEIIKECVMMLVYNQKIHIEKVNNENLIYLM
                     PYYLAENGVCSQIVKLSQYEFEDLKIDIDNEINVLEEDKKIKLAEKQILAVKESVNSG
                     VLIITGGPGTGKTTTINAIIDIFENNGKSVTLAAPTGRAAKRMSETSNKEAKTIHRLL
                     EMGFSTDDDLTFFKDEEDPINSDVIIVDEVSMVDIILMYNLLRAIKLGTRVILVGDSD
                     QLPSVGAGNVLKDMINSNIINVVKLNEIFRQAQESMIIVNAHKINNGEPLYLNTKGKD
                     FFFIRKSTNEEILNEIIGLVNERLPKFYKVDKLKDIQVLSSMRKGELGVTNLNIELQK
                     YLNKKEKFKVEENFSKRLFRVGDKVMQVKNNYTKKWETEDQKESGEGIYNGDIGYVYH
                     IDKDKKTIYILFDQTKIVSYLYDELDEIDHSFCTTIHKSQGSEFPVVVLPIAWAPPML
                     LSRNLLYTAVTRAKKLVVLVGDVKYLEYMIKNNRVNQRYSNLGYKLNKFKQEGLLIE"
     gene            complement(31393..32490)
                     /locus_tag="KNP36_001070"
     CDS             complement(31393..32490)
                     /locus_tag="KNP36_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872958.1"
                     /translation="MSGKVNIKTVISFAGAYVATVIGSGFATGQEILQFFTFYGYAGI
                     IGGIISMVLFSWFGAEVIDKGRELKLKEPIKIYQVYCGKYLGTFFEWFGPLFLFGTLV
                     IMIAGAGATLSEYYGLNPYVGRIGMAIVSLITVSLGLTRLSKILGNIGPIIIIFTLLV
                     GAISLFSNIDALSNAGNMVDSLNIKTATSNGYFSGVLYTCYNVIIVITFLTGMGASAV
                     NKKDAVWGGIVGGVALMAAAIMMNLALLSDIGNIYTKEIPALYLADKISPIIGILFSV
                     VLLLGIYTTAVPLLWSVTNRFVEDDHPKFKIITIVVSILACIGGLLPFDKLVGTLYPY
                     TGYMGILILLCMLYRRITKTEGYKENKSEIS"
     gene            complement(32805..33998)
                     /locus_tag="KNP36_001071"
     CDS             complement(32805..33998)
                     /locus_tag="KNP36_001071"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HBF0872959.1"
                     /translation="MARHLFTSESVTEGHPDKICDQISDSILDALLEKDPQSRVACET
                     TVTTGLVLVAGEISTSAYVDIPKLVRETVREIGYTRAKYGFDCDTCAVITSIDEQSGD
                     IAMGVDEGLESKTGEEIEEEIEKVGAGDQGIMFGFACNETPELMPLPISLAHKLSRRL
                     TEVRKTGLVDYLRPDGKTQVTVEYEGSKAVRVHTVLISAQHCETVSNDKIREDLINHV
                     IKEVIPAELLDEETKIYINPTGRFVIGGPQGDTGLTGRKIIIDTYGGYSRHGGGAFSG
                     KDPTKVDRSAAYAARYVAKNIVAAGLADKCEIELAYAIGIARPLSIFIDTFGTGKVSE
                     EKLVELVNKHFDLRPGAIIRDLDLRKPLYKKVAAYGHFGRTDIDLPWERTDKVEQLRK
                     DALGE"
     regulatory      complement(34135..34238)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            34427..34936
                     /gene="yyaC"
                     /locus_tag="KNP36_001072"
     CDS             34427..34936
                     /gene="yyaC"
                     /locus_tag="KNP36_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protease YyaC"
                     /protein_id="HBF0872960.1"
                     /translation="MYLAKVNYSDDDVIQMLSSVLKTIINENTIVVCIGTDRAIGDTL
                     GPLVGTILKNSNFKYPVYGTLDNPIHALNIYESLDTIKNTHIQGNFLAIDACLGSQSN
                     IGNIQIREGPILPGKGVGKKLPQIGNYSIVGIVDKIDENNKLSFNNIRLSFILDLAET
                     IALALLVST"
     gene            complement(35047..35475)
                     /gene="fabZ"
                     /locus_tag="KNP36_001073"
     CDS             complement(35047..35475)
                     /gene="fabZ"
                     /locus_tag="KNP36_001073"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HBF0872961.1"
                     /translation="MLNIDEIKKLIPHRYPFLLVDKITELEVGKRAVGIKNITVNEPF
                     FQGHFPEYPLMPGVLIVEALAQVCGVAMMSVEENKGKLGVFAGIDKVRIKREVRPGDT
                     LTMEVEMTTLRKNIAKADAKAYVGEELVCKGELMFALVEK"
     gene            complement(35491..36510)
                     /locus_tag="KNP36_001074"
     CDS             complement(35491..36510)
                     /locus_tag="KNP36_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein"
                     /protein_id="HBF0872962.1"
                     /translation="MAGADIGIDLGTANVLVYVSGKGIVLEEPSVVAIDKRTDSVLAV
                     GEEAKKMIGRTPGNIVAIRPLRDGVISDYDVTEKMLKSFIDKIVDKKGFGRFFMPRIM
                     VCVPTGVTEVEKRAVEDATRQAGAREVYIIEEPIAAAIGAGVDISQPNGNMIIDIGGG
                     TVDIAVISLGGAVVSESIKVGGDRFDDAIVKYMKKQHNLLIGERTAEKIKFEIGSAFK
                     REEEKYMKITGRNLITGLPSSITINSTEMLEALRECVEQIVVATHAVLEKTPPELAAD
                     IGDVGIIMTGGGSLLYGLDKIIEQRTGITVTIADEPLSCVAKGTGIALGSIDLLETGG
                     SFKRK"
     gene            complement(36707..36967)
                     /gene="spoIIID"
                     /locus_tag="KNP36_001075"
     CDS             complement(36707..36967)
                     /gene="spoIIID"
                     /locus_tag="KNP36_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation transcriptional regulator SpoIIID"
                     /protein_id="HBF0872963.1"
                     /translation="MRSHIEERAIVVAKYILEKNTTVRQTAKTFGVSKSTIHKDVTER
                     LKEINPSLAKEVKNVLDKNKSERHIRGGLATKLKYEKEHKKM"
     gene            complement(37065..37733)
                     /locus_tag="KNP36_001076"
     CDS             complement(37065..37733)
                     /locus_tag="KNP36_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M23 family metallopeptidase"
                     /protein_id="HBF0872964.1"
                     /translation="MKKKLLEKDGFYLSLFVCVCLLAVGGVWFTNNNVDKLASNKGIM
                     ENANKDSEEEIHLIEKDKKDAIPTATDSKQNLEKAKSKEENKSSTTKLNYIGDKVIRG
                     YSEKEPSYSKTLDVWETHKGVDISCTKGKEVKSLLNGIVVDVFDDEEYGQSVKIKSDN
                     NIVVVYSNLDKNVSVKKEQKVTEGQSLGTVGSTSQIESEEGIHVHLEAYSGEKSIDPM
                     SLIK"
     gene            complement(37799..38863)
                     /gene="spoIID"
                     /locus_tag="KNP36_001077"
     CDS             complement(37799..38863)
                     /gene="spoIID"
                     /locus_tag="KNP36_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage II sporulation protein D"
                     /protein_id="HBF0872965.1"
                     /translation="MKNPLVVLLGFVTCSVLVPSLITLVSYKNVELTEKPESPVSINK
                     TIKKSDIEDKGNKEEKNTVNYETVNKKAPIINVYNHITGKTEKMDMENYLCGVLAGEM
                     SSEFDIEALKAQSVAARTYVVYKQEHGKSSKHKNAVVCTDYKHCQEYKSYDTLKKLNG
                     EEWIKNKYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKS
                     VESPYDKYSPKFASTLKISNTDFVKSLRRAYSTIVIDVNNLSKQVSITKRSDAGTVEK
                     IKLGNKELTGKDIRTVFKLNSANFDIKFGEGYIDFVVKGYGHGVGMSQWGAEGMAEEG
                     YKYYDILSHYYTDTKIKDIY"
     gene            complement(38950..40203)
                     /gene="murA"
                     /locus_tag="KNP36_001078"
     CDS             complement(38950..40203)
                     /gene="murA"
                     /locus_tag="KNP36_001078"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HBF0872966.1"
                     /translation="MAKIIVKKSNPLKGSVKIDGAKNAVLPIIAATLLANGKSTLNGV
                     PNLRDVHVISDLLRHVGAEVEYKENTLTVDASNIKTCEAPYELVRKMRASFLVMGPLL
                     ARFNSTKISMPGGCAIGTRPIDLHLKGFKALGAKIEMDHGFVEAATEKLVGNKLYLDF
                     PSVGATENIMMAASLAEGTTIIENAAEEPEIVDLANFLNEMGADVKGAGTNTIKIKGV
                     KELKGAEHNVIPDRIEAATYMVAAAMTKGDITVENVLMEHLKPVVAKLREAGCEITEM
                     DNSVRVVGPKVLKPIDIKTLPHPGFPTDVQAQFMAMLTVANGTGVVIETVFENRFMHV
                     AEFNRMGANIKIDGRSAVVNGVDELHGAAVNATDLRAGAALILCGLIAEGETQIGEIY
                     HIQRGYVDIDKKITALGGQIEIVED"
     gene            complement(40224..40961)
                     /locus_tag="KNP36_001079"
     CDS             complement(40224..40961)
                     /locus_tag="KNP36_001079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YwmB family TATA-box binding protein"
                     /protein_id="HBF0872967.1"
                     /translation="MKKVKLAISFFILMIIGMTISYADTSINTRYNRLSKALEISEAN
                     FKFYNVKINSVINHNLSNKEFHNIFIEIINNLKLDKKGINWNQKGSGDKIQLCATIKG
                     SDKEISIKGINKNNKESYIVVDILDNKVYKHKEVIYSNVENVLNKYSSQVDVSACIVG
                     EYTKRLQNNKYDDILQKILYNMSAKQIDEVKDVNFLSITAYSKVLNDYELEYLGEKIN
                     LNIGIKYNEDDGKTLIYIATPIIKLDY"
     gene            complement(41417..42712)
                     /locus_tag="KNP36_001080"
     CDS             complement(41417..42712)
                     /locus_tag="KNP36_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiosulfate sulfurtransferase"
                     /protein_id="HBF0872968.1"
                     /translation="MTNDFKKEKKEDYFVNLKAISTEVLQEKVQDNAWVIVDTRLNDA
                     YNGWKLDGVKRGGHIKGAVDFSANWLSVYSDRKDEVLEQALKTKRIDLDKNIVLYDAN
                     GKDALVVADYLSKKGYKYLYKYDIKQWADDENLPMERYKNYQMIVPAFIIKDILDGKI
                     PETFEDSKNIKMIEASWREESYTKGHIPTSVHVNTDIIEPPPTWMLDNDDNLTKFALD
                     YGLTKDDTVIVSSSTPMASYRLAVILRYIGVKDVRVLNGGTNSWLSAGYELEFISNPK
                     HSCTNFGADIPVNSQLIVTTSELRQKLKEKNKFILVDNRTWDEHIGKVSGYTYYDKKG
                     RIPGALYGHSGSDSVSLEEYRNIDNTMRNKYEILEMWDKENIDVNKQLIFMCGSGWRA
                     AEVLTYANVIGVENTSLYSDGWMGWSLDNSNLIEVGEHK"
     gene            complement(43163..44995)
                     /gene="glmS"
                     /locus_tag="KNP36_001081"
     CDS             complement(43163..44995)
                     /gene="glmS"
                     /locus_tag="KNP36_001081"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003401499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HBF0872969.1"
                     /translation="MCGIVGYLGSRKAAEVIVEGLSKLEYRGYDSAGVAVNSSNEKEL
                     NIRKFKGRLSVLAEDLEKNPIDGNLGIGHTRWATHGEPSDVNSHPHFNQAKTIAVVHN
                     GIIENYMEIKEELISEGVKFESQTDTEVIAHLVDKYYEGNLLDAVYKTISKLRGAYAL
                     GVICKEHGNELVAVRKDSPLVVGVGEGENFIASDIPALLKYTRDVYFLENGEVVHLKD
                     ENVTVYDSNRNLVEKEVFHVTWDVEAASKGGYDYFMSKEIHEQPTGVRETLERRLDDN
                     GNIILDSINISKEDLEKINKVYIVACGTAYNAGLLGKYAIEKFVNIPVITDIASEFRY
                     SDPFVDENSLVILVSQSGETADTLAVLRDSKAKGARILSITNVVGSSIARESDDVFYT
                     WAGPEVAVASTKAYTTQITSLYMIALDFAIKKGTITREFYDSMISKMKEIPSKIQEIL
                     DNEEYIKEVAKTVVSSEHAFYLGRGIDYSLAMEGSLKLKEISYIHAEAFAAGELKHGT
                     IALIEKGTPVIAIATQEKLFEKMVSNMEEVRARGAYVVAIAQSHNKDVEKAADKIIYI
                     PNSDDILSPILAVVPMQLLAYHVSVLRGCDVDKPRNLAKSVTVE"
     gene            complement(45262..46608)
                     /locus_tag="KNP36_001082"
     CDS             complement(45262..46608)
                     /locus_tag="KNP36_001082"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HBF0872970.1"
                     /translation="MRKYFGTDGVRGVANTELTCDLAYKLGRAGGFVLAQGDHRVKVV
                     VGKDTRISGDMLEASLIAGLMSVGCDVITVGIIPTPAVAYLTRKYGADCGVVISASHN
                     PVEYNGIKFFNKNGYKLDDEIELKIEEYIDDIDKIDCLPIGENVGRKLHEHCAQRDYV
                     DYLKSIISTDFKGLKVVLDCANGASYKVAPIVFDELGASVISINSSPDGNNINYKCGS
                     THPEQLQRAVLEHNADLGLAYDGDADRLIAVNEKGQIVDGDHIMILSALNLKKNNKLA
                     QDTLVVTVMSNIGLTIAAKENGINLSTTAVGDRYVLEDMVKNGYNLGGEQSGHMIFLD
                     YNTTGDGVLSSLILANIILQEKKPLSEIASIMSQYPQVLVNATIKNENKNKYMEYPEI
                     KTEIERIESILDGNGRVLIRPSGTEPLVRVMLEGKEEGQIKELATNLANLIQEKLS"
     gene            complement(46778..47335)
                     /locus_tag="KNP36_001083"
     CDS             complement(46778..47335)
                     /locus_tag="KNP36_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBF0872971.1"
                     /translation="MSTARVICAGFGGQGVMSMGQLLTYAGMLEGKEVSWLPSYGPEM
                     RGGTANCAVTVSNEPVGSPLITDDATAAILLNIPAFEKFKDDVIPGGKIIVNSSLIKE
                     KVDRTDVDVYYIPANELAAELGNDKVANMIMLGAYLKVSDTVDIESVLEAFKKVFGPR
                     KEKFVPLNREALQKGMDATCSKATN"
     gene            complement(47336..48088)
                     /locus_tag="KNP36_001084"
     CDS             complement(47336..48088)
                     /locus_tag="KNP36_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBF0872972.1"
                     /translation="MAVVFKKTEGLQDTQTHYCPGCTHGIIHRLVGEVLEELGVLGDA
                     VGVVPVGCSVLGYKYFNCDTQEAAHGRAPAAATGIKRVHPENTVFTYQGDGDLASIGT
                     AEIVHAAARGEKITTIFVNNTTYGMTGGQMAPTTLVGQRATTAQSGRNAETQGYPIRV
                     SEMLATLTGAVFVERVAVDTPAHVRQAKKAIKKAFQVQQAGLGFGIVEVLSTCPTNWG
                     LAPNDALQWLRDNMIPYYPLGNFKNVEVEEVK"
     gene            complement(48088..49167)
                     /locus_tag="KNP36_001085"
     CDS             complement(48088..49167)
                     /locus_tag="KNP36_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBF0872973.1"
                     /translation="MAKILMKGNEAFGKAAIEAGCKYFFGYPITPQSELPEYLSRELP
                     KIGGAFVQAESEVSAINMVYGGAGAGARVMTSSSSPGVALKQEGITYAVGAEVPCVVL
                     NVMRGGPGLGSIQPSQADYFMSTRGGGNGDYRTPVFAPATVQEAVDMIMEAFDVADYY
                     RSPVMVVADGMIGQMMEPVEFRAPEKKRELPPKDWATVGTKGKRKPNVINSLYLEPEV
                     LEDHCWHLQEKFDAMEKNEVQYEMYKTEDAEFVFAAYGTTSRVVKSAIDILREEGIKA
                     GLIRPKVLWPFPFEAFNQIPNARNILTVEMSMGQMVEDVKMAVEGKLPVYFHGRPGGM
                     TPTPAEIVEKAKKIIAGELVAGGAR"
     gene            complement(49196..49411)
                     /locus_tag="KNP36_001086"
     CDS             complement(49196..49411)
                     /locus_tag="KNP36_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0872974.1"
                     /translation="MAKGKVSFNQERCKGCGLCVEACPVKIIQLDSNVINKKGYNPAT
                     VFEMEKCIGCASCATMCPDVVITVERD"
     gene            complement(49454..50131)
                     /locus_tag="KNP36_001087"
     CDS             complement(49454..50131)
                     /locus_tag="KNP36_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0872975.1"
                     /translation="MITNDKRIRIITGHYGSGKSEFAMNYVVKLRDMVSGKVAIADLD
                     VVNVYFRTREKKELMKSLGIQPIDSSINAPTLDLPAVSAEVMSPMVDHSYNSVIDLGG
                     DNVGARVIGRFSHLLKEGDYDMLFVINANREKTQTSEEVIQYIKEIEKSSKLKVTGLI
                     NNTHLIRFTTIDDVLRGQKVAKEVSEKCNIPIRYVACLENLVEQLPKDLEGEIFPIKL
                     YMREDWM"
     gene            complement(50121..51200)
                     /gene="buk"
                     /locus_tag="KNP36_001088"
     CDS             complement(50121..51200)
                     /gene="buk"
                     /locus_tag="KNP36_001088"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBF0872976.1"
                     /translation="MSKIFKILTINPGSTSTKIAVFDNEDLVFEKTLRHSSEEIGKYE
                     KVSDQFEFRKQVIEEALKEGGVKTSELDAVVGRGGLLKPIKGGTYSVSAAMIEDLKVG
                     VLGEHASNLGGIIAKQIGEEVNVPSYIVDPVVVDELEDVARISGMPEISRASVVHALN
                     QKAIARRYAREINKKYEDINLIVAHMGGGVSVGAHKNGKIVDVANALDGEGPFSPERS
                     GGLPVGALVKMCFSGKYTQDEIKKKIKGNGGLVAYLNTNDAREVEERIEAGDEKAKLA
                     YEAMAYQISKEIGASAAVLKGDVKAILLTGGIAYSKMFTEMIADRVKFIADVKVYPGE
                     DEMIALAQGGLRVLTGEEEAQVYDN"
     gene            complement(51222..52124)
                     /gene="ptb"
                     /locus_tag="KNP36_001089"
     CDS             complement(51222..52124)
                     /gene="ptb"
                     /locus_tag="KNP36_001089"
                     /EC_number="2.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate butyryltransferase"
                     /protein_id="HBF0872977.1"
                     /translation="MRSFEEVIKFAKERGPKTISVACCQDKEVLMAVEMARKEKIANA
                     ILVGDIEKTKEIAKSIDMDIENYELIDIKDLAEASLKSVELVSQGKADMVMKGLVDTS
                     IILKAVLNKEVGLRTGNVLSHVAVFDVEGYDRLFFVTDAAMNLAPDTNTKKQIIENAC
                     TVAHSLDISEPKVAAICAKEKVNPKMKDTVEAKELEEMYERGEIKGCMVGGPFAIDNA
                     VSLEAAKHKGINHPVAGRADILLAPDIEGGNILYKALVFFSKSKNAGVIVGAKAPIIL
                     TSRADSEETKLNSIALGVLMAAKA"
     gene            complement(52428..53609)
                     /locus_tag="KNP36_001090"
     CDS             complement(52428..53609)
                     /locus_tag="KNP36_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872978.1"
                     /translation="MINRLKNNTKIKIISFLSAIALWMYVMAVVDPEETKGFEDIPVS
                     ISNMSDLKDKNLVIYPDEKLTADVYIKGSLSKVQSVKKEDIHVYGTIEDPIQGQKEVY
                     LKANIPQGVTLEFKHDVLVVNLEKNIKEKRDIKVEVSGNSKRNINKIELSKEFVDVSG
                     PRTLVKEVKSVRANLDVGNETDDFSKKLQLIPLNSDGTKVEGVTLSSSFVTAKIELLK
                     EKIVPIRVSLNDNKDNDVLKNYKLSKEQVTIKGKKEDIDKISYIKTKPIDLADLANGE
                     EKEVSLEIPEGITLEDSSITIKLNDTKQLSAEFLYNAGDIELRNIPTNMDNPNVISDV
                     DIKVVVESMEDLSKLNKKDISLYIDLSQGPEEDSKYKIKYETTYQFKKINIEPNIVEV
                     E"
     gene            complement(53606..54445)
                     /locus_tag="KNP36_001091"
     CDS             complement(53606..54445)
                     /locus_tag="KNP36_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HBF0872979.1"
                     /translation="MLDINSFLNGFFNIILRMSIYDLIDISIVAYIFYKIFMFIKDTR
                     AEQVFKGIIFLLLATQLSNTFKLHTVYWISLKALDYGVIAALIIFQPEFRAGLEHIGR
                     AKFNLFGKNVNTSEETLNRNIEEIVEALYSLSRQKIGALIIMERETRISDIINTGTII
                     DAEISRQLLINIFIPNTPLHDGAVVIRDSKVKAAACFLPLTESKDLSKDLGTRHRAGI
                     GVSEVSDCITLIVSEETGGVSIAKAGKLYRDISRERMMNILRSNLKTNTETRSFFKGG
                     IFK"
BASE COUNT        16504 a        10329 c         5807 g        22051 t
ORIGIN      
        1 ctgtcattaa tttataatat tcaataaaat attttaattt agttaagaat ctatattgta
       61 aaggagtatt aaattaatga acttaaaatt aatatggata aatattctaa acccagtatt
      121 tattaaaaat gaaataaaaa gaaaaaaaat acaaattatt atctttttct ttataaactt
      181 tggtttaact tattcattag gtttactgtt atattataat aaatttattg atccagaaaa
      241 ctttgcatca ttcatgatga tattacctct atcttcagtt gccattgcaa agttttatac
      301 tgaaggatta aataatgata tgtatgaatt ttattcacta atcatattat tttttcttat
      361 ttattcatta ttaattgttc ttaagttatt aaatctaata aataataatg aatttataat
      421 tataaaccta atattaactt ttataagtag cttatcaatt ataatatatt catcaaataa
      481 aaaaaattta tatcctgtaa aaaatattaa actaggttct ttattaatta tttactttat
      541 gatttctgta attgttccaa catcatttat actaatacta caaggggctc aacctaatta
      601 tagtggtatc ataaaattta tatttactcc aataacatca ttaactacta tttatatttt
      661 ttttagtgaa gaatatgcct ggagaggttt tttacagaat attttttttg ataaatttgg
      721 taaaaagtta ggagttataa tattaggtat gtgttggagc ttgtggcact taccactaat
      781 atttacatta tatacacctg aagcgccaat attaggaata atattacgtt caatacatat
      841 agttggaatt tcaatatttt taggatatct ttatataaaa actaagaata tctggttttg
      901 tgctataatt catgttttaa ataatagtgc ttttcttatc acaaattcta aagaatcaac
      961 tatcacttac catgatatac taatagtatc tatggttgtt ttaatttttt atgttccatt
     1021 tctatttaca aaagaatata aaaataactt ggagtaaata gaatatccaa gttattttta
     1081 tatttttgca aatttccaac aatcctacag aatactttaa gcttagaaga tattattaaa
     1141 atttattata atcaactaat tcttgatatt ggtcacattt actttatcac taacaaaatc
     1201 atacttagaa tctctatagt aataccatac aaatataaag ctaagtagat taacaaaagt
     1261 agtcaaaatt ccaccttcaa taccaaacat tcctccattt aatagattac catgagtgat
     1321 ttgtgtagtt ataatccctg gaacttgaag tccacttaca ggcataccat atataatccc
     1381 ctgaaataca ttccatgcaa aatgataacc tatacacatc catatattcg acgattttat
     1441 aaacatatat gaaaaaagaa tcccaataat tataatatta attacagaca aaaaagtaac
     1501 atcaggattc catatatgaa tcaacccaaa aataacagat ggaacaatca ttataaaata
     1561 aatattttta catcttcgta aaactgccat aaaaaaacca cgatttaaaa tttcttctgc
     1621 aaaagcaact aaaataaaga ccagtatcca agaaactgtt aaaggtgaaa tttttggtac
     1681 ccatgaagta acatgaccac caccaattgt tattgttata ataaagatta ctgtacaatt
     1741 aaatattcct aataacattc ctacatatcc ttcttttttc ttaattctat aagaatgtaa
     1801 tcccatttca ctaataggat ttttcataat aaatctccat acaattatag gaataataat
     1861 cataagtgaa tctgttagaa tttgaaatac aatctgtaac ccaacatcat ttaaccaatt
     1921 agcatattct gaaaaatagt ttgtttttaa attaatgtca cctgtagcaa ccaggatttt
     1981 tcttattatt tccacaagta tcatgcttaa ataatactga agtatgtaaa aggtagccat
     2041 aacagctata ataatccacc ctgaacgtac ttttttgtct ttattcttaa taatcaagtt
     2101 gctccatgat ttgttcatat agatgtcttc ctcctaacta ttatttttag ttgtttctaa
     2161 aatatattct attaaatttt ttcatagtag tattttacca caaaacttct gcttcaatga
     2221 agtaagcgta atatattctc taactgtaat ttaaactata aaaaatatat aaagtatatt
     2281 taaagcaata tttatggaca taaagcaata taaacaatat ataaaacata taaaacttta
     2341 cttaattatt tctacataaa aaccacataa aaaaggatgt aactctagct tttagtgtaa
     2401 catccttttt ttaattaaaa cttgtattta attttagaaa gctgtctcat gaccaacata
     2461 acaagctata ccattatcca aaaatatatc ttgtaattct tcaagatgac cttcatcaac
     2521 atcaccctta tcagaatact catattcctt gcctaattga atccattttg attctcctaa
     2581 tctgtgaaat ggtaatagat taatttctac caaattattt ttgtgcataa aagatataat
     2641 atcacttata ttttcaacac tatcattaaa cccagagata actggtactc taagtactaa
     2701 tcttccattc caatcagaat ttgcaaggtt tgatatattt tctaatatta aatcattata
     2761 cacacctgtt tgttctttgt gtttttctct atccatatgc tttatatcaa taaatgcaaa
     2821 atcaatatcg ttaaatattt tattaaaaac ttcatttgat acacatgcac tcgtttcaat
     2881 ggcagtgtgt atatttacct catgacactt taataatact tcatgtaaaa attcatgctg
     2941 aagtagtggc tcacctccac taaatgttac tcctccatta cttctccaat tgttagaatc
     3001 acgtttaatt acctgcacaa gttcatctac agtgtaaggt tttgcacata atttaaacgc
     3061 attataataa catgagttga cgcattcaaa actttcacag tccttacaga tgttccaatc
     3121 tataactggc ttattatcaa gattaaagct caatgcacca tttttacact taccatgaca
     3181 tacagtacat ccattttcat attgacaaga taattcacta aacatcatat gtggtcttac
     3241 agtccaactt tctggatttg cacaccattt acaactcagt ggacatccat ttaaaaatac
     3301 agttgttcta caacctggac catcatgaac tgaaaagctt tgtacatcaa aaatcatgcc
     3361 ttctaattgc ttttgactac tcattaaaca catgtccttc acaagtaatt gcattcaatg
     3421 ttgaatatac ccagtcttct ttctctaggc caacacattt gcctatacct tcatcattag
     3481 cttcaacaaa atttttacaa tttttacatt ttggcattac ttttatctct ggacatgctg
     3541 catcatctaa attaatcatt tgttttgata atctacaaat tcctttggtt gcatctactg
     3601 cacaaaaatt catacaatca ctatgctttc tcatatttta caccccttca tactctgttc
     3661 tagcaattac ttcatcttgt attggtttac ctaattcaca ccaatattga gtaaacccag
     3721 caacacgtac cattaattga cgataattgt caggattttt ttgtgcatct tttaatgttt
     3781 ctgaatctac aacattatat tgaatatgga acccaccttt tcttaaataa cttcttgtta
     3841 aatctaataa ttttttagtt ccttgttgtc cttttatagt agttggatga agttttaaat
     3901 tcatctgaga attttgaact actgcttggt cccaaatagt tgcagattca aataatgcat
     3961 atactccatt tttatctgtt cctgcatatg cagagactga accatctgaa tatgttgttc
     4021 cacttagtct accatctgga gtagccaagg tagcagctcc ctgtggccca tgtgtagaaa
     4081 cagatatttg gcaagggtac atcttcttag catataaaga ttgtgcttct tcacatactt
     4141 ttgataacca tacctcatag tttttaagaa tattatctgc atacaaatca ttatttccat
     4201 atttaggtgc atcaagacag gccttataaa tagcatcata tttaccagtc ttatctactt
     4261 ttacttggtc tgccatagaa taatttccta cttctaatgc atctttaaat ccaaaattat
     4321 ttaatatggc atccttcatt tcctctattg taaatgcttt gtcatcatat acaagtttct
     4381 taagtgctgc aaatgaattg accatagtaa cagtaccaca agtttctacg tttaatgttg
     4441 cattataacg atatcccata tttcctatat gttgaccttt gtctaaacag tctggcttta
     4501 gtagtgaatt tattatagaa gtatcaaatt ttctccatat atctaactca atgttatttg
     4561 ctctttctaa aacatttatt gcttgtttat aataatcttt aaatacttct atgacttctt
     4621 cataagtatc taatggctta ttatgaggct caaatacttg tatattcata cgatagtctt
     4681 taccattcat aagaacaagt tctaaaattt ttggattagc tataaagtga actccagagc
     4741 cagcagattg acctgctcca cctgcaatag agtatgtttt tccgtttaaa gttaactgtt
     4801 tccaacaccc tggagacgtt tccaaacatc cacctaatgc aaatgctctt gcttcttcaa
     4861 cagtcatacc ttcatcagca aattgtttca tcataaatgt tgttccattt gagttgttta
     4921 cccatgctgg ataaccagaa ccaagctttg tacattcagc agctttcatt aagaaatctt
     4981 ctggaagctt ttcatcatat agcatagtta aactaggttg aggagttcta catctcatac
     5041 ttgcttctaa taataactct tctagttcat tagctcctgt agaaccatct tcttttaatc
     5101 cacctataga taaagtatta aatgtattgc ctgatagtac tcctccattt acgcccgctg
     5161 aagcaaaaca gtcaatacaa gtgattttta ttctataaag ctctaataat tcgataacct
     5221 cttcttttgt aattagtcct ttttctatat cttgttcata ccaaggatat aaaatttgac
     5281 caaaacgtcc tatagacata ccagatatag catcctcatt tactgatgct atatgaattg
     5341 tataagtcaa ctgaagagct tccctaaatg tacgaggttg tttatgtgca atatgttcta
     5401 atatctccac taaatctgag tattcttttt tagcttctaa atctgtctct atactttcta
     5461 aatattttgc atgttttgca taatttaaaa tccaagtttg taatccttca ataacttgaa
     5521 taacagcctc ataaaaatat agacggtcca taccaataag cccatctcca gatgcatttc
     5581 ctgcaactgc ctttttacat tcttttgcca tttctataat tccatctaat ccataattta
     5641 aaggataaaa ataatttata acttctctac cttgaggaag tgtataccct gaatcaaaca
     5701 tgcatataag tgtactcatt aggttttctt ttaaatcata atctggcatc attttttcat
     5761 agtgaaaacc taaatcttca acagactttc caacccattc ctttgccatt tttacaagta
     5821 caggtacttc ttcttttctc attccgaatt taccagctat tgaaacgaca tttccaaaac
     5881 tttcagtaac atttcctcca ccagacccaa attttgtaag ttcatcagct gtgttactgg
     5941 ctaatttctt tgcctcttct ctcatttgtt ctccttgagc aacaaagaag ctttcactta
     6001 cccatggcat tggaaaagaa cctctataat ggcgtgtctt ttgcattact attttctcac
     6061 caggtattat atttggtgtc atatgtgaaa aagcagcttt aagagcttta gctcttctaa
     6121 ctactggtat atcaccatct gattttctat attctctatt ataccaatat ggaaattcca
     6181 tatcagcagt agataatgta ttataatata catctaataa gtcttctgct cttttacttg
     6241 cttttttttc attaaattca cttaaatttt ctttattttg aaaatttgat ttaatatttt
     6301 ttgcttccaa aatacttctt attttgtctt ctttactttg actcatttct tcccctcctt
     6361 aatctttcta taattagtat aaaacttttt aagaatgaaa aaaaagggta tattacccac
     6421 tttttaaaat aatctttcta tagaaaaaaa taaacttgaa gcaaatctaa gccaaagaca
     6481 atctgtatat cctaaaattt gttgcaattc attggaatat aaagattata aatagtttta
     6541 cttcaagttt taatatatac tatatttatt tttattatat ttaatttcac ttctacttac
     6601 ttttttgaaa caatactttt atatttacaa attcatctaa ctctactgat ttatctttaa
     6661 atttggaact gcatttaaac tcatatcatg cgttttccca tttataaaat tataatatcc
     6721 tgcacaccct atcatagctg cattatctgt gcataaaatt agaggaggat acttaacagt
     6781 aataccattg tctttagcaa gctctgttat tttagctcta agccccgaat tagaagcaac
     6841 cccaccagaa agagttatga tattgtatcc tttgtctttt actgctttta gtgctttagt
     6901 agataaaacc tctactacag cctcttggaa agatgctgct acatcttcaa ctactatttc
     6961 ttcatttttc attctttttc catttagata atttaataca gaagatttta atccactaaa
     7021 actaaaatca tagctatctt cttctaaata ggctcttgga aattctatag catgtttatt
     7081 tccattcttg gccagattat caataatagg acctcctgga tagcctaaat tcatagctct
     7141 tgaaatctta tcaaatgctt ctccagatgc atcatctctt gtttttccta aaatttcata
     7201 cttgccataa tcttttactt caaccaagtg agtatgacct ccagatacta ttaatgttat
     7261 aaaaggaggt tttaaatcct tatgctctat atagtttgca cttagatgcc cttctatatg
     7321 atttactcct acaagtggaa tattcaaagt atatgcaagt gctttagcat aagatagacc
     7381 aaccaataaa gcacctacta gcccaggtcc atatgtaact gcgatatggt ctatatcatt
     7441 aaaacctata tttgctttgt ctaaagcttc ttgaacaact atatcaatat tttccacatg
     7501 ttttcttgag gccacttctg gaactacacc accaaatttt ttatgtgtct cgatttgagt
     7561 agagattatg tttgaaagta cttctctacc attttttaaa actgatgcag ctgtttcgtc
     7621 acaactactc tctatagcta atgttattat atcactcata aactctacac ctcttttaat
     7681 tggttccaca ttataattgc atcttcttta ttatcactgt agtattcttt tcttattcca
     7741 cccattttaa atccatattt tctatataaa ttttgtgcta ttttatttga tgctctaact
     7801 tctaatgtca tagatgcaat attattatct ttacataaat caactatgcc ttttatcaac
     7861 ttgtccccta tttttttccc tctatagtca ctatgaacag ccacattatt tatatgccct
     7921 tcatcaagta taagccaaat tcccacatat ccgacaattt ttccatttaa cttagctact
     7981 atataccttg ctacttcatt agacaactct tttctaaaag actcttttga ccaataatct
     8041 tcaaaacaat ttttttctac ttcaaaaact tcatctatat cttctgtagt catttcttct
     8101 atttttatat catctactat tagttttgta ttatcttcca ttatttagcc tcttcatttt
     8161 ttcatcatat tgtacttcag cttgagattt tctgatatac ataggattta tcgtataaca
     8221 agtatgtaca tctatatttt tattatattt atttaatgct aaagagcata agcttcctgc
     8281 gttagataca ttattagctg gtgaaggtat ttttatattt tttatattct ctaacttgtc
     8341 tttatatttg tatacagctt ctccaactat tataaattct tcattagttg atacaatttc
     8401 atctactaaa gcatcaaact ctacaacatc aacaccatct aattctatca tctctccatt
     8461 ttcaaacttg tatttagctg aataaacttg atttttctgt gcatctaata tacaacatat
     8521 ctttctatca cagaaattta tgttatttgc tagagattcc aaagaattta ctgctattat
     8581 tggtatatta tttacatggg ccatagcttt tactgtagcc atacctattc taagtcctgt
     8641 aaacgaacct ggacctatac atacagctaa taaatccata tcttttatac ttaaatcact
     8701 catactcaac atattttcta tcattggcat aagcttttgt gaatgagttt ttttgttgtt
     8761 tactgtaaac tcacatatta agttatcatc ttcaacaact gctacacttg ctgccataga
     8821 agacgtatcc atacctagta ttttcattat ttaatcaact cctcaactat ctctttataa
     8881 aactctcctt ttggagttaa tatcatttct cttccttcat ctttatatct caattctata
     8941 ttcaaatatt cttttggaag tatatcttct attagattag cccattctat tatacagatt
     9001 ccatttgaat ttacatattc atcataacca atatcataca tttcatcact actacctatt
     9061 ctataaacat caaaatgata caaaggtatt tttccttcat attcatttat tatagtaaaa
     9121 gtaggacttg ttatataatc ttctatccct aatgaatctg ccaaactttg tgtcattgta
     9181 gttttaccag ctcctaaatc tcctactaaa cagataacac tgccttcttt taaaagttta
     9241 cctaatttat atcctatttc tctagtttta ttttcatttt ctaaatatat ttttgccatc
     9301 aattcatctc cattttgata taatcgtcat gtgaatttat atcactgctt aattaattat
     9361 agtataagcc tagattatta taaagtactt gtctttatct ttttttatct ttcactattg
     9421 atggctgtat ctacacctta tatacaatca tcaatagcaa tttttacata ctcttttgct
     9481 ttatggtttt gcttcaatgc ttctttacat attctctcag attgctcttt tacatactta
     9541 agagacttat agttctcttt tactgcttca atacacattt tttctgtttg attttttata
     9601 tacataagca tttttccatt ttgtcttaca atctctatac atatatcttc tgtatactta
     9661 tctatgtaac ttagtacatc tttaatatta tattttttat ttaaatatct tatagcattt
     9721 atacatattt cttctgtctt attgttgaca aattgtatac ttcttccatc ttgtttgaca
     9781 gcttctatac atattttatc agtttgttta tttacatatt gtaatgccat accattttgt
     9841 cttacggatt ctatacacat tttttccgtt tgatttttta catattttaa tgctttataa
     9901 ttttgcttaa tggcctctat acataattct tcactctgtt ctctaacgta tgcaagacac
     9961 ctgccatctt ttttaattgc ttctaaacat atccttcttg tttgagtctc taaagccttt
    10021 agtatactta caacatctat attggaagaa tgacttattg cttttataat aagcccttct
    10081 gttttatttc gtacatactt aagtgcatta caatcttttt ttatagcttc aagacacaag
    10141 tattctgttt gttcttttac atattcaagt gctttataat tatactttat tgcttctaaa
    10201 cataattctt cggtttgatt ttttacatac tctaatgcct tgtaattctg ccttattgct
    10261 aaaatacaca taccatcagt ttgattttct atatttttta attcacgata atcgtatttt
    10321 accctttcca tattttcaat atattcatta gtgatatact ttaaagaatc tcctaatttt
    10381 gtatcataaa taccaatatg aatatctttc caattactat taaaataata ccctttatca
    10441 tctaaaaata atttttttat ttttttagat aaatgcatga atatacaccc ctatcattat
    10501 taaattagtt attattaaaa gtttgattat taatctttat agttttttaa taataacttt
    10561 attttttgtt tattataaat tcgctctgta tattgtagat acctttttca tattttaata
    10621 gttaatcgtt ttaattcttc ctttatttta aaatttaaat ttgtctaaat atttcttatt
    10681 ttatatacat tttttgataa attaataaag ccataatata tttaatatat caatcacaat
    10741 ataggactga agttataaat aaattatggc tattcaatac atttaatttt atattttctt
    10801 gtctaattat ttctttatta tatttcccat ttttttataa agtggcaatg ttactaaaga
    10861 tattataaca gccttcagca cattaaatgg agctatcatc caaattacaa aagtgaataa
    10921 atcatgaact tgaggattta tagctgaacc taaacctatt atagcatcta gtcccataag
    10981 ttgaccataa agtggcaaca ttacaaaata atttactaat gaaccaatta tagtcataga
    11041 tattgttcct aatacaaaac caatcagtac accttttaaa tctccacttc tcttatatga
    11101 ataacaaagt atcattacat aagaaccacc aattaatata tttgcaaatt ctcctattcc
    11161 tccagttgtt gttgctgtta ttgcttgtaa cacatttttt actacaacta ttccaaatcc
    11221 aactaatggt cctagagaca ttcctccgaa tattgctgga atatctgata agtcaatttt
    11281 taagaaatct ggaaatatac ctggtattgg tgcttgaata aacattaata aataagatat
    11341 tgcagataaa attgacatta ctactaaagt tcttgttgaa atcatattgc ctctttttgc
    11401 tgtgttttgc ataattattt tccccctaat caatatgttt atatttttta ggaaaaacaa
    11461 aaaactcgaa gaccctatct tcgagttttt atggatatag tttaaacaaa ctaaaataaa
    11521 cttatttatc ttccataaat atcttctctc atccagactt tactgtcggc tttggaatct
    11581 caccaaatca accacctaag tagttcgcgg gctataccgc cggtagggaa tttcaccctg
    11641 ccccgaagat cttctttgat tttttaattt tccttacact cttatattag ttaatttttt
    11701 aataattgtc aagttatttt ttctcataca ctactttgcc atttattata gtgtaaagta
    11761 cattactttg aatctctagt ggagaattat cccaaattac taggtctgca tctttaccaa
    11821 cttctataga gcctactcta tcttctattc ctaaagcctt agctggattt atcgtaattg
    11881 attctattgc tttttcttct ttcataccat gttttactgc aatacctgca catattggaa
    11941 gatattgaac tggtattact ggatggtctg tcattataca tacatcaaga cctgcatttg
    12001 aaagtattcc tgctgtatta aatgtcaaat ttctaagctc aaatttagac ctttctgaca
    12061 aagatggccc tactattaca ggaaaccctt cttccactaa ttcatctaca ataagatgac
    12121 cttctgtaca atggtctaat gtaagcttta aattaaattc ttttgcaatt cttattgctg
    12181 taaacatatc atctgctcta tgagcatgtg ccttaaaagg aatttctctt cttaaaactg
    12241 gtattaaact ttccattttt atatcatatt caggtttttc acagtcttca tcatcatgac
    12301 tctcatacat atcaatatcc tctaaatatt cttctgcttt ttttaggttt tctctaagta
    12361 aagcagctat agccattcta gtttgaggag atttatcatc ctgaccataa cagctctttg
    12421 gattttctcc aaaagcaatt ttagatgcaa ctggattttt tattaccatt ttatcaattc
    12481 tttttccaca tgtctttata gctatacatt gaccacccat aacatttgca cttccagggg
    12541 ttgtacaaac agaagttatt ccaccttcaa aagcttcttt aaaagttcta tccattggat
    12601 taattccatc tataggattt aattgtggtg ttattgggtc agtctcttca tttccatctg
    12661 ctccttcaaa ccctatacca tcttcccata aacctaagtg agtatgagca tctataaatc
    12721 caggaaacac aagtttatta ctagcatcta ttacctctac atctaaagga gctatcaaat
    12781 cttctccaat ttctattatt tttccttcat ctataagtat atctccatga attatcccat
    12841 ttgttatggt atttatttta ccatttttta taaaaatcat tcattttcct cctgattttc
    12901 aagactatcg ttcttatttt aatatatttt cttactatat acttttacaa atttttaaca
    12961 tttatacact cgagtaatct tatttacaaa tatagaatct aagtactata accatacata
    13021 aacttatcta ttttttcatt gataaggcaa ctcttttttt gtttaagtca attccaatga
    13081 cttttacatc tactatatca cctactgtaa caatactcat agggtctttc acaaaactat
    13141 tactcatttc tgatttatga actaatccgt cattttttat tccaatatct acaaatgcac
    13201 caaagtctac aacatttctt attgtacctt ttaaagtcat accctcttgt atatcttcaa
    13261 tttttaagac atcagttcta agtataggtt ttataccttc ttctcttggg tctcttcctg
    13321 gttttttgat ttcagctatg atatctttta acgtaacttg tcctacttcc agtttttcac
    13381 ttaattccct caagccaatt tcttttattt tttcatctat ttcacctata ttcttattct
    13441 ttacatcatc taaagaatat ccaattatct caatcatttt tttacatata tcataacttt
    13501 caggatgcac acctgtatta tctagtggat ttttaccctc taagattctc ataaatccag
    13561 cacattgagt aaatgcttga ggtcctagtc tttttacttt tttcaattgt gctcttgacg
    13621 taaaatctcc attttcttct ctatatgcta ttatattttt tgctatagct ttacttattc
    13681 ctgcaacatg ttctagtagg gagtatgatg cagtatttaa atctactcca acactattta
    13741 cagaatcttc aacaactcca tctagtactt cttctaatct ctttttgttt aaatcatgct
    13801 gatattgacc aacaccaata cttttagggt ctatttttac aagctctgct aatgggtctt
    13861 gtaatcttct agctatagat atagctcctc ttattgatac atttatatct ggatgttcct
    13921 catttgcaag ttcagatgct gaataaacag atgctcctgc ttcactaact atcacatact
    13981 gcacttcgct atctatttct tttatcattt ctgatacaaa agtttctgat tctctagatg
    14041 cagtaccatt tccaattgaa attatatcta tatcgtattt ttcaatcaat ccttttaaaa
    14101 ctttctttgc tccctctaca tcattttgag ggtctgttgg atatactgtt gtataatcta
    14161 gtagtttacc atttttatct actacagcta ttttacatcc agttctaaat gcagggtcaa
    14221 atcccataac tactttgtct ttaactggtg gttgaagcaa taaactttta acattctttc
    14281 caaatacact tatagctctt tcttgagcta tttctgttaa atgatttctt atttctcttt
    14341 ctattgatgg gaaaattaat cttttataag aatcttctat tgaacttacg atttcttctt
    14401 tatttttgaa atttttatca tttacatatt cgtttattat gtaatttaaa actttatcat
    14461 tatttatttc caacttaacc tttaggaagc tttctttttc tcctctgttt attgccaaaa
    14521 ctctatgtgg agccatactt tttactgctt cgctataatc ataatacata tcataaaccg
    14581 atttctcatc agtagcactt ttgctaacta tcataccttc tcttaaagct aattctctta
    14641 tatactttct aatcttagca tcatctgaga ctagttctgc aattatatct ctagcacctt
    14701 ttagagcatc ttcaatagaa agaacttctt tctcttcatc aagataattc tttgcctcta
    14761 tttctatatt atctaaatta ttctctagta ttgacaatgc taaattttct aatccttttt
    14821 cttttgctat tgttgctcta gttcttttct tttgtttata tggagcatat atatcttcta
    14881 cttcttgtaa tgtttttgct ttttctatat tttgtgttat ttcatctgtt aatttccctt
    14941 gttcatctat tagtctaact acatcatctt ttctactttg aagatttctc aaatacatta
    15001 atttttcata aaattctctt agtgtaacat cactcatttc gccagtcatt tcttttctat
    15061 atctagctat aaatggtatt gtatttcctt catcaataag ttttaatgta ttatttattt
    15121 gttcatctct aagattaaac tcttttttta agatttgatt tatatccaat ttattcactc
    15181 ctaatgttag tttttcataa gtataacaaa acagaacgaa ggctgagggt tatcgtcctc
    15241 agcctaagtg ctgtaagtgc atattaagca ctaaccttct tatacatata tcttaattac
    15301 agtgcatatt tattaaacta ttttattcat ttttaagtat tcattaataa acaagtctat
    15361 atttccattc attacactat ctacatttcc aaactcagca tttgttctat ggtctttaac
    15421 caatttatat ggttgaaaaa catatgacct aatttgacta ccccaagtta tttgtgagta
    15481 tttgccttgt atatcttcta ttttttcctt ttgctctaac tcttttaatt ctatcaattt
    15541 cgccattaaa agtctcatag ctctgtcctt atttagatgc tgagaccttt cattttggca
    15601 ctgaactact acaccagtag ggatatgtgt tattctaact gctgaatcag tcgtatttac
    15661 atgttgccct ccagctccag aagctctata tgtgtctatc tttaaatctg atggattaat
    15721 ttctacttct atattttcat ctaactctgg tgttacatct atagatgcaa atgaagtatg
    15781 tctttttcct gatgggtcaa atggagatat tctcactaat ctatgaactc ctttttcact
    15841 ctttaaatac ccataagcat ttgttccttc tacaagaatt gtagctgtct ttatccctgc
    15901 ttcagggtct gatattatat ctaaaagctt aactttataa cccttacttt ctgaccatct
    15961 tatatacatt ctcaaaagca tttgagccca atcttgagca tctaagccac cagtaccagc
    16021 atttatagat aatatagcat tatttttatc atactctcca tttagaagag tctttatttt
    16081 catttcagat aatttttctt ccattgattc tatggacttt tctatatctc tttctacaga
    16141 atcatcatct tcttctaaac ctatttcaat taatacttct atatcttcta ataagctttt
    16201 taagctttca tattcttcta atgtctcttt taaagattta ttttcttgaa gtactctttg
    16261 agcgacttca ttatcattcc aaaaatcttg ttgattcatc ttttcttcat taatttgtat
    16321 atttttcatc aatgaagcta tgtcaaagag aaaccctcaa ttcttctaaa tttgaagcca
    16381 tctgctccat actatgtcta tactcttgta actttaacat ttaatcctcc gagattatct
    16441 tccacaacag tttttatatt ttttaccact tccacaaggg cataagtcat ttcttccaac
    16501 cttttcatct tttttaacag ttttacttgt tggaagtgtt ccatctgatg gagaagatag
    16561 attttcaaca tctacaactg cttttctttc cactggagtt tctattgtta tattaaataa
    16621 atatcttaca gtatcttctt tgatatgttt attcatttca tcaaacatat caaaaccttc
    16681 cattttataa gcaataactg ggtcttgctg acctacagca cgaagaccaa taccttggcg
    16741 taattggtcc atagcatcta tatggtctat ccaatggtta tcaacagctt gaagtaagat
    16801 tactctctca acttctctca ttctctcata gccaacttgt tcttcttttg aagtatatat
    16861 cttcatagct atttcataaa ctttttctgt tatttcaact ggattaagtt tttctatttc
    16921 tggtatttct atgctacctt ttggcaagaa cagattatac atatgttctt tgaatccttc
    16981 ttcatcaaat cctttatctt gtgtataaag agtaactgct tcttctatta tagaatgagt
    17041 cattgattgt atttgttctt gtaaatcttc accttctaat acacgttttc tctctgcata
    17101 tattatttct ctttgtttat tcataacatc atcatattga agtacatgct ttcttattcc
    17161 aaagttttta ccttcgactt tcttttgtgc tccttcaata gacttagata atattctatg
    17221 ttctatcggc atgtcttctt caagacctat tttatctaca ataccagata ttctatcact
    17281 accaaacaat ctcataaggt catcatcaag acctatatag aatcttgaac tccctgggtc
    17341 accttgacgt ccagcacgac ctctcaactg gttatctatt cttcgagatt cgtgtctttc
    17401 tgtacctatt atagcaagtc cacctgcttc tacaacttgt ttttgttctt cttgtgtttg
    17461 ttgcttaaac ttttcaaata gtttttcata ctcttctcta gcttcaaata gaatttcatt
    17521 accttttaca ggtatacctt ctattggagt atctactcta tttactattt cttctttaaa
    17581 tccatttctt ctcatttctc tcttagttaa aaagtctgga tttccaccta gaactatatc
    17641 tgtaccacga ccagccatat tagtagctat tgtaacagct ccaagtctac cagcttgtgc
    17701 tattatttct gcctctttat catgatgctt agcatttaat acctcgtgct ttatgccctt
    17761 tttctttagt atttgtgata ataattctga tttttctatt gatactgtac ctacaagtat
    17821 tggttgattg actttgtgcc tttcaattat ttcttgtgct acagcattaa atttacctat
    17881 ttcacttttg tatacacagt ctggtaagtc ttcccttatc ataagcttat tagtaggtac
    17941 ttggaaaaca tccattttgt agattgcttt aaactcttct tcttctgttt ttgctgtacc
    18001 agtcatccca gaaagttttt tgtacattct aaagtaattt tggaatgtta cagtagctag
    18061 tgttttagat tctctttgta ttttaagacc ttctttagcc tctattgctt gatgtaaacc
    18121 ttctgaatat cttctaccaa acataagtct acctgtgaac tcatctacta ttactatttc
    18181 tccatcttta gcaacataat caacatcttt cttcattatt acatgtgctc ttaaagcttg
    18241 atttatatga tggtataatt ctgtatgaga tatatctgtt atattatcaa cattaaaata
    18301 cacttctgct ttttgtatac ccgatgctgt tagagataca gccttatctt tttcttctaa
    18361 ttcataatca tctggtttta aggttaaaac aaatgtgttt gcatctgaat ataagtgagt
    18421 tgatttgtct ccaggtccag atatgataag tggtgttcta gcctcatcta ttagtataga
    18481 gtcaacctca tccactatag cataatttaa tcctctttga actctttgct ctttgtgtat
    18541 taccatattg tcctttagat agtcaaatcc atattcatta tttgtaccat aagttatatc
    18601 acaatcatat tgttcttttc taacttttgg attttgaccg tgtataataa cgcctacact
    18661 cattcctaaa aactcataga tttttgccat ttggtctcta tcacgttttg caaggtaatc
    18721 atttactgtt acaacatgta caccttttcc agtaagcgca ttcaaataaa caggagcagt
    18781 tgcaaccaaa gttttacctt cacctgtttt catttctgct attcttcctt gatgtagtac
    18841 tatacctcca atcatttgaa ctctgtagtg tctaagtcct aacactctct tagaaacttc
    18901 tctaactact gcaaaagctt ctggaagtat atcatctata ctttcaccat ttgctaatct
    18961 ttctttaaat atatttgtca tatttttaag ttccgagtct gccatagatt caaatttagg
    19021 ttctaatgaa tctattatat caacagtttt attgaacttt tttaattctt ttttatctgc
    19081 catgttgaat aaattatcca taaagctcat attttacatc tctcctcgtt ctttattgta
    19141 ctattattca ttttaccata aaaactatac ttttaatatt aatttaaaaa gctatcgata
    19201 atttatttat cgatagctaa tatgattaaa tctaaattgc tttattcatg ttctattata
    19261 ccatatccac cattattacg cttataaact actgctattt catctgaatc tatgttcttg
    19321 aacatataaa aatcatgtcc tattaattcc atctgtaata cagcttcttc ttcactcatt
    19381 ggcttaacac taaatttctt acgtctttga attactaatt cttgattttc atccccataa
    19441 ttctcttgtt catcagctag atttatctct gcatcttgga atcttatact cttgttgtct
    19501 ttatgtttat cttgtaatct ctttttatat ttttttaatt gtttacttaa tttatcatat
    19561 acaacatcta tagctgtgta taaattttcc tgcatatctt ctgctctaat tataggacca
    19621 tttacagtag ctattgttac ttctattttt tgtcttgctt ttctcgcact tactgtaact
    19681 tttacatcag tgtctggatg aatgtaatta tctaacttac ttagtttagt ttcgatttta
    19741 ttttttattg catcagttaa ttcgatttgt tttccagata taattatgtt cataaataca
    19801 tctcccttca attatgccag tataagaaaa tttatacttt aataatatat tctacacgaa
    19861 ctctcataat cctcttttta ttatttactt ttatgatttt ttctattcaa ttgatagaat
    19921 tatttatcat ttttagttac attgatactt atgtggatta atattattac aaacacctgt
    19981 ggataatgtg gataaaactg ttaataactc ttgtttttgt ttatttaaag ctatttttac
    20041 tcctatttct atccacaaaa atctccatta attgtttatt aatatgtgaa ttcatgtcat
    20101 aagatggtaa ttttaggaaa ttatgtgtat tatatgccaa tataccttta taatttttta
    20161 ataaatataa accctctaaa acctccataa tctatctttt ctttcattat ttatatttaa
    20221 aactaattaa aagttataaa gcatactcaa caataatttc atatttaata cctattaaca
    20281 ttcatatacc caaattataa ttaacttact ctctttattt aaactaagta ttttatattc
    20341 atatactatc ttgaaattat atttacgagt tgtttaagct tttgtctatc tatatcttca
    20401 aaaggactgt tatttattct aatcgctgta ccaaaatgaa aattacttgc cttagttaat
    20461 tcctttatct tttctatatt attaaaatta agacctccac ctaaaagaat ttttatgtga
    20521 ttagaactaa gcatcatatt ctttatcatt tgtatgttat caactatact tcctttccct
    20581 cctgatgtta atatattcgt aattttatca taatccttca aaattttaac actatctatt
    20641 gtatttgatt catctattgc tctatgaaat gtaacatcaa gattatcaca acatttcaat
    20701 aaaacattta gatttttctc atctatacta ttgtttttat ccaatacacc aaatacaact
    20761 ccattagcac caatctcttt aaccacactt atatcttttt gcattatact tatatcttct
    20821 ttactgtata caaaactttt cgcatgatgt cttatcatta cgttcacagg tatctttaca
    20881 ctgttaacaa cactttctat aagaccaaaa cttggtgtca atccaccttc agttaaagca
    20941 ctaactaact ctattctatc tgcaccacaa tcttctataa ttttagcgtc ttctactgac
    21001 attcctatta tttctaacat aactactcct ttgctaattc atatattgca tttgcaaata
    21061 tctttgcatt taatattata tcttctatat ccatgtattc atcaggatta tgagctattc
    21121 ctttttgtcc tggaaatgaa ggtccaaacg gaactatatt tggcattact tttgcatacg
    21181 tacctccatt agttgttacg ggagttccat ctaatgatgt aaccctttca taagctagct
    21241 gaagcttttt aacaagatta ctctctttat caaaatatac aggattaaaa ttagaaatta
    21301 cctctatatc gatactattt ggaaaactag cttttatttc atccaataca tctttcaatt
    21361 tataactaaa atcgtatttt acctttatat ctaatatagt atcactattt tctatattca
    21421 gctctttata tgtaacaagc acattttcag acatattttc tataaaacct aggtatacat
    21481 cttcttcata attgatttta ctttttattc taatctttgc catgcctttt tcaccatata
    21541 caacaggata tttacaatct ggtgtaaatc ccataatagg tgctttttct ttttctaaat
    21601 aatatggtat atcttcaaat ccactttctt catttgtacc aaatattatt ctaactctct
    21661 tatctaattt taagtttaat tctttaatag catataatcc atataaggca gacattatag
    21721 gtcctttatt gtctagtact cctcgtccat aaattcttcc attagtttct tctcccttat
    21781 aaggctgatg cttccaacca tctccttcat gtacaacatc tacatgtcca attacacaaa
    21841 cataatcatc actatctcca tgctctgcat aaccaatata attatccaag tttctaacct
    21901 taaatcccaa tttttctgat atttctaatg ctttattaag tgcctcccct actttttcgc
    21961 caaaagggaa gccattttct gactcccctt tgacactagg tatttttaca atatctataa
    22021 tatcacttaa taaatcttct tttaactcat ctattttatt acttatgata ttcataaaaa
    22081 tctccttatt ataaaactct attttaatta tgtaaccact actttactca cttacttcta
    22141 ttggtgcttt tattctagcc tcatatgctt ccatccactc atttgatata accttatgta
    22201 tagtctttcc atctactcta tttgaaatat atacagtagg agattcttct ttagttacta
    22261 ctgaaaaagt aaaatcagct atatttgtag ctactcccca ttcaccttta ttattcatgg
    22321 caactaatga taaatcacca gcttttcctc ttcttttgat aagctgttta tcaagttcat
    22381 ttactgcaat atcacatgct tcttgtggat gcttcccttc tttcataagt ctaactatct
    22441 cataagatat acatcccttc attaaatctt ctcccaaacc agtagctgta gctcctccta
    22501 tactactatc aacatagaat cctgaaccag atagtgcaga atctcctatt ctacctcttt
    22561 tcttcataaa caatccactt gttgatgtag ctgcacacat ttttccagtt ttgtctaaag
    22621 atatcatacc aacagtatca tgaccagcat atgggcttaa tcctttgtct aaagtctctt
    22681 tttttctctt tttataatgt aacttcgctc tatcagtcaa catatttttt ctttcaaatc
    22741 catttttatg agcataatct tcagcaccta ttccaactaa aaaattattt accttctcat
    22801 aacttaactt cctagctatg ctgacaggat tagaataatc tcttatacca gcaactgcgc
    22861 caatatctaa tgtgttacca tccataaatg cagcgtcaag ttctacctca caattttcat
    22921 ttggaagtcc accatatcca accgatttat agaatggata gtcttcaact cttcttacag
    22981 caagctctac agcatcacct gcttccatgc ctttttctaa atgttctgat gcctcagtta
    23041 ttccttctag ggccattctc catgtcgcta tcattcccca catgttaaaa ttcccctcct
    23101 taaattatat agattttact aatgtatgct tattataaat agtataatat ttaaacttgc
    23161 taataattaa tactcttatt gataacaaaa ctcttctttc atcaaagtta tatcttcttt
    23221 atttgctatt gcttttgcca atttacatat gttatttaat gaatcattaa gaccaattcc
    23281 accttttttt ggagtcttaa ctatacatat gtcattttta tattcgttta tcacatctat
    23341 attttcttct gacatagctg caaaagctgg tatatctgtt ttatcattta tatttttaga
    23401 cagtattgct gacatcttag aaaagttttc gtaattaaag cttggtccac agattactac
    23461 atcagggttt aattttttta ccatagctat catcttactc gttacttctt cttgattatt
    23521 tacaaaaaat tcatccccac aaaataaggt agctattacc ttagattcat ttaaaaattg
    23581 ctccatcatt acacctggtc ctaatgggct tgattttcca gcaggaggta tattactttt
    23641 ctcttttcct ccagctccag cttgtatttg gtccaatatc ataactattt tcttcataat
    23701 cttcctccta taatactaaa tcatcaaaag atatatcatc atcttcctct tcaacagttt
    23761 cattttcttc tctcaagtat tgcttatcta gcatttttat aaatggtata tacataaata
    23821 ttcctagtat aagaagtact aattgtaaga ctgcaccttg ccatcctgtt gttaaaaaac
    23881 cagagaatat aattggagtt gtccacggta actgaactcc atttgtaaga ggcactaatc
    23941 ctgctgacat acagaagtaa gctattatta tatttattgt tggaactatt gcaaatggta
    24001 tcaatagtat tgggttaagc attattggta gaccaaatat caatggctca tttataccaa
    24061 atattcctgg taaaattgat agttttccca ttgactttat acgtttactt ttacatatta
    24121 ataacatagc tatgactaat gatagtgtac tacctgctcc accaaatgtc gcaaacatat
    24181 cttggaattg acctgttatt atgtttggta tttttgaacc agcttgaaaa gcagctaagt
    24241 tttcagctga tagaattttt aatattggat tatacacagc cccaacaaca ctacttccat
    24301 ttattccaaa gaaccagaat aaatgtaaga atatataagc gattgccata gcacctaaac
    24361 tatttcctaa ttttaataat ggcatttgta aaaacttaaa tataaattca tgtatacttc
    24421 catatggtgt agcttcaaaa gctatcttaa ctaaaaagaa aactaccata actattgcac
    24481 ttggtattaa tgctgcaaat gattttgata cagttggagg aactccatct ggcattttca
    24541 atgtccatcc tttttttaca actgcagcaa ataattttac agaggttatt gctgttatca
    24601 tacctacaaa cattccctta gaacccatcc aacctagtgg tatacctgtt accatgtaaa
    24661 ctgattctgt tccttctggt gtatatggta ttacaaatgg tgttattata aaaaaggcaa
    24721 ctattgcaac tgctgctgat gctattgggt ctacatctat ttgctttgca taagaatatc
    24781 caatccctaa aactgcaagt agagtcatta cttcaaatgt tgctacagtt ggttgttgca
    24841 attttacagc ccaatctgga ccaaaaattt gacctacaaa ttcattccat ccttttatag
    24901 gaaaatttgc tactaataaa aataatgaac ctattattaa taatggtgat gatactaaaa
    24961 aaccatctct aattgcaatt aataatttat ttttacctat tttttcagcc aatggcataa
    25021 gtattctttc caatctattc atctatccac cctcatttcc tattattttt tactataatt
    25081 ctacgcttgt ttagatttta ttagctttat agcaagtttt aatacttttt ccccattcat
    25141 agttccataa tcaacttcat tgattatatc tataagtttt ccttgagctt caaactttgg
    25201 ttttaactcc tttagcatgt atttaacttg tggtcctaat aatatacaat ctggattttt
    25261 ttcttcaact attttgtcaa tttctgctat cggaaatgcc tctacttcta ttggtaaatt
    25321 gtgttcatct gctaccttct gcattttatc tgcaagtaaa cttgttgaca taccaaagct
    25381 acaaaataaa tatacttttc ttttcatttt ttaaatcccc cttaattttt ttattttaat
    25441 ttttgaattt cttttcttaa cataatcatt tcttttataa ggtttctctc actcatacaa
    25501 gtcattaaat ggtcttgaga gtgaatcaat aaaatagata tatctgattt atctccccca
    25561 gcttcctttt gtataagttc agtttgtact ttatgtgctt ttaaaatttc ttcatttgca
    25621 ttttcaatta attcatctgc ttttttaaaa tcgttttcct ttgcatagtc aagtgcttca
    25681 taaagcatag attttgcatt tccagcatga attataatct ttaaaactat ttcttccatt
    25741 ttttcctcct aagttgcttc tctactttta gattatttat accttacaaa catataatat
    25801 cttataaaaa caaaaaaaca tgcacaactt tttccatcac atggaaaatt ttgtgcttat
    25861 ccatagttca ctatgaattt tatataagaa tatcttttac cttttcaatg tcacatttac
    25921 ttagaatatc tagcatattt tcatcctctg ttaaattaga tatttcttta aataattctc
    25981 taaatacttt tctatcatca tcttttttat acgctaacaa aagtataatc tttatatcct
    26041 ttccatttct aatttttatt ggtgttttta accttgcaaa acataaaaca gattgtttta
    26101 tatatttcat gtctccatga gggaataata ttccttttcc aacattggtt ggatatgact
    26161 tttctcttgt tataatagat tgtaaatact ctttttctgc ataatgtttt tcaattaata
    26221 aattagttaa atatgttata gcttcataaa tatcatcatg ttctaactct cttattaaat
    26281 aatcagacat cattaatctg ttcataagtt tatatgaagt gtctttttct tttattttgt
    26341 ttgtgaactc tttaagttta ttctcatcct catcagtaaa taatggtgtt gttataaaaa
    26401 ttggtttttg gatattttca tactcttgaa atgcaattat aaaatctata gtcttattaa
    26461 agttatctct ttttaaatct tcctctctta atgtttcaat aatttttatg ttatcaaatc
    26521 tcttttctat ctttactttt aatagcatac ttactccaaa actaaatgga catacaatac
    26581 ttgccttttt atttgattcc cttttgctgt attttctttc tagagaggtt tgaaagtgaa
    26641 gtgtaagata accaatttca tcttccgtta tttgttttcc ttttaattca atttctattg
    26701 aacttgatat tactgtaaat aaaaaacaaa atttagtttt tatgttatct aaaagtggat
    26761 tttctaagta aacattgctt ttcatttgat gcattgtaac attcaaatga catattaatt
    26821 gttcataaag taatatatca ttattaaaat ttattcctga ttcttctgat actaaattta
    26881 taattttttt tgtataactt gctaattctt catttagata taaagatttc ttaatattat
    26941 tactatttat ttgtttgttc atacccaata ttaaagattc tataaacaat ttttcttcat
    27001 aatttaatac tatggataaa ttagatttca attcatcttc tatatccaat ataagcattt
    27061 ttagcttaag ctctttctta gtatttgata cttttaaaga atttcccagc cttattcgta
    27121 ttatatttat aagcaaaaat agcatcaatt gcttgaatga tatatctgta agtcttatat
    27181 ccatatcctc ttctatagta agcattatgt tttttacaat tattatatct actatatgga
    27241 agtactctat ttcatctatg tttaatctgt atttatctat atatttaaat aagaatgata
    27301 ctaacattat tcttatgtct ttctcatccc cttcaatata tataccactg ccttttttag
    27361 tcgagatatt taaattataa ttatttaatg ctactgataa tttacttatt tcttctctga
    27421 caatattttt atttatgtac aacttattag ataaatcatt taaagtaact tttttattat
    27481 tacaaagtag taaatttagt atctcaactt gcttatgaag ctcactattt actcttttaa
    27541 cttcacctcg caacttctga tttaccagta ttttgtctgt tccatctcca ctaaatttaa
    27601 tcccaatatt aggttttctt ttgatataag cattacaaaa agtagataac cattcatcaa
    27661 tatatttgca atcatttctt attgtccttt ctgaacactc aaaatcattg gcaatcttat
    27721 taacatttat aaactcttct tttaatagca atgttgttaa taaattttct tgtcttttat
    27781 tcaaacatat cacctcttta tgactcaacc taaatttatt atatataaaa aagagctata
    27841 cataaaggta tgctagctct cttttaatat gatatttagc tgacctggtt tttgacccca
    27901 cactcgccta ctggagggtt cgcttgggtt cgccgcacta ctactctctc tcgattttat
    27961 tatcggtagg tcttacttct aagccgcacc atgatcatta acccaatttt tagtgttaac
    28021 ttacgtggat ccctttgcct gcgactggct tggactttca accacagacc taaatatcac
    28081 ttattcattt taatatttta aactaaaatt gtcaatatat aagattattc cataatataa
    28141 ttatcatttg cttttgtaag tagagtcaat acaaaaacct tattagcacc tgataacttt
    28201 aaaagtttag aaatttcgtt tgttgttaga ccagtagtaa atatatcatc tattaaaagt
    28261 atatttttat tatttattaa tttaacattt tctttaacaa caaatacatt ttttaattct
    28321 tcttttcgtt ctttcttatt caatttatat agcattcttg tatatttttt tctacttatg
    28381 caatctaata atggaatatt tactatttta cttaaattaa atgctatttt ttgtgcctga
    28441 ttaaaacctc ttttatttag ccttttttta tgaagtggaa caaataatat ataatcaaat
    28501 tttatgtttt ctaaatataa tttttctttc attatttgag ctatatactt agccataaag
    28561 gttttttggt tatacttcag ccctaacacc atcttttttg tcacatcatt gtattcaata
    28621 caagatattg atttatcaaa ataaaagtct ttattaaaac aataactaca ctcttcaata
    28681 aattcttttt caattgaatg acgtattatt ggttttccac acttcatgca accatcttgt
    28741 ataaaattca tttctttaaa acaactttta catattgaat aagtatttgt tttctttatg
    28801 gatttatcac aaattatgca acttatattc tcaggatata taaaatccaa acatttatta
    28861 atcatatttt taaaattctt aataaaatta tcattgcata ttttcatatt tattctatca
    28921 acaacccttc ttgtttaaat ttatttagct tatatcctaa atttgaatac ctttgattaa
    28981 ctctattatt ttttatcata tattcaagat atttcacatc tccaactaat acaactaatt
    29041 tttttgctct tgttactgct gtatataata aattacggct aagtaacata ggaggagccc
    29101 acgctattgg caatactaca actggaaatt cacttccctg gcttttatgt attgttgtac
    29161 aaaaactatg atcaatttca tctaattcat catataggta tgatacaatt ttagtctggt
    29221 caaataatat ataaatagtt ttcttatctt tatctatgtg ataaacatat cctatatctc
    29281 cattatagat accttctcca ctttcttttt ggtcttctgt ttcccatttt tttgtataat
    29341 tattttttac ttgcattacc ttatcgccaa ctctaaataa tcttttagaa aaattttctt
    29401 caactttaaa tttttctttt ttgttaagat acttctgtaa ctctatattt agattagtaa
    29461 ctcccaattc accttttctc attgaagata aaacttgtat atcttttaat ttatcaactt
    29521 tataaaattt aggtaatctt tcattaacca atcctattat ttcatttaaa atttcttcat
    29581 tagttgattt tcttataaaa aagaaatctt taccttttgt atttagataa agtggttctc
    29641 cattgtttat cttatgggca tttacaatta tcatactttc ttgcgcttgt ctaaatattt
    29701 catttaattt aactacattt atgatattag aattaatcat atccttaagt acatttccag
    29761 cacctacaga aggtaattgg tcactatctc caactaaaat tactcttgtt cctaacttta
    29821 tagctctaag taaattgtac attaagataa tgtctaccat tgatacctca tcaacaatta
    29881 ttacatctga atttattggg tcttcttcat ccttaaaaaa agttaaatca tcatctgttg
    29941 aaaatcccat ttctagcaac ctatgtatag tttttgcttc tttattagaa gtttcactca
    30001 ttctctttgc tgctcttccc gttggagctg ccagagtcac acttttacca ttattttcaa
    30061 atatatctat gatagcatta atggtagttg ttttaccagt tcctggtcca ccagttataa
    30121 ttaatactcc actattaaca gattctttga ctgctaaaat ttgtttttct gctaacttaa
    30181 ttttcttatc ttcttctaaa acattaatct cgttatctat atctattttt aagtcttcaa
    30241 attcatactg tgataatttt actatttgac tacatactcc attttcagct aaatagtatg
    30301 gcataaggta tataagattt tcattgttta ctttctctat atgtattttt tgattataaa
    30361 ctagcatcat tacacactct tttattattt ctccatttag ctccaataat ttttccgaat
    30421 cttgtattag aacatgctct ggtaaatatg tatgcccatt acttaaagat ttatttaaag
    30481 tgtataagat tccctgacaa attctatctt tagagttttt atctatacca attttacttg
    30541 ctatactatc agctacttta aatccaattc ctcttatatc ttcagcaagt tggtatgggt
    30601 ttttatttat aacttctatt gcactgcttt tatatttttt atatattttt aggcagtaat
    30661 ttggtgttat tccaaaagga gatagctgta ttattatatt tctcaattct ctgtcttctt
    30721 cataactttt tactatttgt tttacttttt tactccctat accttctact tcttgtagtt
    30781 tttctggtga attttgtatc acctctaacg tatctacacc aaacttatca attattcttt
    30841 ttgccatttt ttcaccaata ccatgtatca ttccagaaga taagtaaaca taaattcctt
    30901 ctaaggatga tggtgttact ggcataaaac tattcacttc aaattgagtc ccataaatct
    30961 tatgatttac ccactttcct tcaacttcta tgctttctcc aattgctaaa gtaggcatac
    31021 atcctacaac cacaatttca tcattttcat ttaccaggtg agctattgta taaccattat
    31081 cttcgttttt aaagactatt tcacttatca ttccttctaa tttttccatt tttatctcct
    31141 aaaaatacta ataatcgctc catttaaatg ttagtataat tttatatatt aaaactatga
    31201 taatcgtaga aaagttttat atttttatac ttaacgtaat ttccaactat tatacatttt
    31261 atcagaaaca aaaaaaatct gcatccataa aatatggtac catgaaatac aggtaccata
    31321 tttaaatagc tattttattt taattactct atatttagag tataaattaa atttcataag
    31381 tatattacag tactaactta tttcagattt attctccttg tacccctcag ttttagtaat
    31441 tcttctataa agcatacata gtaaaattaa aattcccatg taacctgtat atggatatag
    31501 tgtacctact aacttatcaa atggcagtaa acctcctata caagctaata tacttaccac
    31561 tattgttata attttaaact tagggtggtc atcttctaca aatcggtttg ttactgacca
    31621 taacaatggt acagctgtag tgtatattcc tagtaaaagt actactgaga ataaaatacc
    31681 tattattgga gatatcttat cagctaagta aagtgctggt atctcttttg tgtatatatt
    31741 tcctatgtct gaaagtaatg ccaaattcat cattatagct gctgccataa gtgctactcc
    31801 acctactata ccaccccata cagcatcttt cttatttact gcagaagctc ccattcctgt
    31861 caagaatgtt attactatta ttacattgta acaagtataa agtactcccg agaaatatcc
    31921 atttgatgta gcagttttaa tatttaaact atcaaccata tttccagcat ttgataaagc
    31981 atcaatattg ctaaataaac taattgctcc tactaaaagt gtaaatatta ttattatagg
    32041 tcctatatta cctagtattt tagaaagcct tgtcaaacct aatgaaacag ttattaggga
    32101 aacgattgcc ataccaatcc tacctacata tggatttaat ccatagtact ctgataatgt
    32161 agctcctgct cctgcaatca ttattactaa tgttccaaat aaaaacaatg gaccaaacca
    32221 ttcaaaaaat gttccaagat attttccaca atatacttga taaattttta ttggctcctt
    32281 aagtttcaat tctcttccct tatctataac ttctgctcca aaccatgaaa atagtaccat
    32341 agagattatt ccacctataa tacccgcata tccataaaac gtaaaaaatt gcagtatttc
    32401 ttgaccagtt gcaaatccag aacctattac agtagcaaca taagctccag caaaacttat
    32461 aaccgtttta atatttactt tgcctgacat acactactcc ccccaattaa aattattttt
    32521 aaagtgtaag tttattaaga ttatattaga ctcattattg tgatatttca atatattttt
    32581 aattatttaa cattagttaa cacattctta accatccttt aacatatatc ccataatatg
    32641 tataaattta gtagagtatt atataaaatg tattgaccag attaaatact gtttattcat
    32701 tatatgatga taaattaaca tttattaaaa atatttaact cataataaaa aagctgttag
    32761 aaagtaatcg taaaattaca ttctaacagc tttttagtta aaaattattc acctaaagca
    32821 tcttttctta actgctcaac cttgtcagtt ctttcccaag gtaaatctat atcagttcta
    32881 ccaaagtgac cataagcagc aaccttttta taaagaggct ttcttaaatc taagtctctt
    32941 attatcgctc ccggtcttaa atcaaagtgt ttatttacta attcaacaag tttttcttct
    33001 gaaaccttgc ctgtcccaaa agtatctata aatatagata atggtctagc tatacctata
    33061 gcatatgcaa gttctatctc acatttgtct gcaagaccag ccgcaacaat attttttgca
    33121 acatatctag ctgcgtaagc agcagatcta tcaacttttg tagggtcttt tcctgagaaa
    33181 gctcctccac catgtctaga atatccacca taagtatcta ttattatttt tcttcctgta
    33241 agacctgtat ctccttgtgg tcctcctata acgaatcttc ctgttggatt tatataaatt
    33301 ttagtctctt catcaagtaa ttctgctggt ataacttcct taataacatg attaattaaa
    33361 tcttctctta ttttatcatt tgatactgtt tcacaatgtt gagctgatat aagaactgta
    33421 tgtactctta cagctttact tccttcatat tcaacagtaa cttgagtttt tccatctggt
    33481 cttaaataat caactaaacc tgtttttcta acttctgtaa gtcttcttga taatttatgt
    33541 gccaaagata tcggaagtgg cattaattct ggagtctcat tacatgcaaa tccaaacatt
    33601 ataccttggt ctccagctcc aactttttct atttcttctt ctatctcttc tccagtctta
    33661 ctttctagac cctcatcaac tcccatagct atatctccag attgttcatc aatagaagtt
    33721 ataactgcgc aagtatcaca atcaaatcca tattttgctc ttgtatatcc aatttctctt
    33781 actgtttctc ttactaattt aggaatgtct acataagcag atgtacttat ttctcctgct
    33841 actaaaacta aaccagtagt aactgtagtt tcacaagcta ctctagattg tgggtctttt
    33901 tctaataatg catctaatat tgaatctgat atttggtcac atatcttatc aggatgtcct
    33961 tctgtaactg attctgacgt aaataaatgt cttgccattt ttattccccc ttatttattc
    34021 ttaattttta ttataggttt taccttgttt ttaattttag aaatttactc aaaataaaaa
    34081 aacctctcct ttataagaag aggttaataa tcgtaattac atactaatta actgacctca
    34141 tctttcaaga cttttgtctt gtaggaatta gcaccttttc ccatttgggt ggttgctggg
    34201 cttcacaggg cctatccctc agcctctctt gataaggtaa tcaagattta agttttgttt
    34261 tactttacta gcttactatt tttttaaaat tttgtcaata tttttagtca tattttttct
    34321 attccttttt ttgtaagaca aataaaattt tctatctatc tgaaatttaa agttaggtct
    34381 ttttaatgct ttttattcat atattttttt gaagggggtg ttcctattgt atttagctaa
    34441 agtaaactac agcgatgatg atgttataca gatgctaagt tcagttctaa aaactataat
    34501 taatgaaaat acgattgttg tttgcatagg aacagacagg gctataggtg atactttagg
    34561 ccctttagtt ggaacaatac ttaagaacag taactttaaa taccccgttt acggtacact
    34621 agataaccct attcacgcct taaatatata tgagtcttta gatactataa aaaatacaca
    34681 tatacaaggt aacttcttgg ctatagatgc ttgcttgggg tcgcagagta acataggtaa
    34741 tatacagatt agagaaggac ctatcctgcc cggaaaaggt gttggtaaaa aactacctca
    34801 aataggaaat tattctatag taggaattgt agataaaatt gatgaaaata ataaactttc
    34861 atttaataat atacgcctta gctttatatt agatttagct gaaacaatag ccttggcttt
    34921 attagtatcc acctaatcta aatataaact aaatgataaa attctttata taaaaaggta
    34981 gatattttag agtatctgat taaatactcc aaattatcta cctttttact tttatatttc
    35041 aagtttttat ttttctacta aagcaaacat taattcacct ttacagacaa gttcttcacc
    35101 tacatatgcc ttagcatctg ccttagctat attttttcta agagttgtca tttcaacttc
    35161 catagttaat gtatctcctg gtcttacttc tctcttgatt ctaactttat ctatacctgc
    35221 aaatacacct agttttcctt tgttttcctc tacagacatc attgccactc cacatacttg
    35281 tgctagagct tctactatta gtactcctgg catcaaagga tattctggaa agtgaccttg
    35341 gaaaaatggt tcattaactg ttatattctt tataccaaca gctcttttcc caacttctag
    35401 ctctgtaatc ttgtctacta ataaaaatgg atatctatgt ggtattaatt tttttatttc
    35461 atctatattt aacattctaa actctcctaa ttattttctt ttgaaagacc caccagtttc
    35521 aagtaagtct attgaaccta aagctattcc tgtacctttt gcaacacaag ataatggttc
    35581 atctgctatt gtaacagtta ttcctgtcct ctgttctatt attttatcta atccatataa
    35641 taatgaacct cctccagtca ttattatacc gacatctcct atatctgctg ctaactcagg
    35701 aggcgttttt tccaaaacag catgagtagc aactactatt tgctcaacac attctctaag
    35761 tgcttccaac atttctgttg aatttatagt tatagaacta ggaagtcctg taattaaatt
    35821 tcttcctgtt atcttcatat atttttcttc ttctctctta aatgcagaac ctatttcaaa
    35881 cttgattttc tctgctgttc tttctcctat aagaagattg tgttgttttt tcatatattt
    35941 aactatagca tcatcaaatc tatctccacc aacctttata gattcactta caacagctcc
    36001 tcctagagat attacagcta tatctacagt acctccacca atatctataa tcatattacc
    36061 attaggctgt gatatgtcta caccagctcc tatggcagct gctattggtt cttctatgat
    36121 atatacttct ctagctccag cttgtctcgt agcatcttct actgctcttt tttccacttc
    36181 tgtgacacct gttggtacgc ataccataat tcttggcata aaaaatcttc caaatccctt
    36241 tttatcaact atcttatcta taaaagattt taacatcttc tcagttacat cataatctga
    36301 aattacacca tctcttaaag gtcttatagc gactatatta cctggtgttc tccctatcat
    36361 ctttttagct tcttctccca cagctaaaac agaatctgtt cttttgtcta tcgccacaac
    36421 agatggttct tctaaaacga ttcccttacc actaacataa acaagcacat ttgcagtacc
    36481 taaatctatg cctatatcag ctccagccat tttttcaact cctttattta taatattaga
    36541 ttatattata agcctatttt aatactccta taataaagca tatacaaaaa tctcgcttta
    36601 atcaagagaa aataaatctt ttgagagtat tattattttg ctatttataa ttacttaata
    36661 tatttctttt tataatttaa ttcaataaaa aaagtaggtt tttaacctac atttttttat
    36721 gttccttctc atattttaat ttcgttgcta atccccctct aatatgtctc tctgatttat
    36781 ttttgtccag cacattttta acttctttgg caagggatgg atttatttcc ttcaatcttt
    36841 ctgtaacatc cttatgaatt gtacttttac ttactccaaa tgtcttggcg gtttgtctta
    36901 ctgtagtgtt tttttcaagt atatattttg ctaccactat ggccctttcc tctatatgag
    36961 atctcaaaga ttacccccct cacataatag ctttaatgat atatatgtaa aaacaccaaa
    37021 aaatataaca agcttaacca aatatgatta aacttgttat actattactt aattagactc
    37081 attgggtcta tagatttttc tccactatac gcctctaaat gcacatgtat accttcttca
    37141 ctttctattt gagaagtact acctacagta cctagagatt gtccttctgt taccttctgt
    37201 tctttcttaa cactaacatt tttatctaga tttgaatata ctactacaat gttattgtca
    37261 ctttttattt tgactgattg tccatattct tcatcatcaa atacatctac tactattccg
    37321 tttaatagag attttacttc tttgccttta gtacaactaa tatctacacc tttatgagtt
    37381 tcccaaacat caagtgtttt agaataacta ggctcttttt ctgaatatcc tcttattact
    37441 ttatctccaa tgtaatttaa ttttgttgta ctcgatttat tttcctcttt tgacttagct
    37501 ttttctaagt tttgttttga atccgttgca gtagggatag catctttctt gtctttttca
    37561 attaaatgta tttcctcttc actatcttta ttagcatttt ccataattcc tttattagaa
    37621 gccaatttat ctacattatt atttgtaaac caaactccac ctactgctaa taaacaaaca
    37681 catacaaaca aagataaata aaaaccatct ttttctaaca gctttttctt cattttgcac
    37741 ctccaaatat atttctacat ttggattatt gacgtgtttt tggcatttta tacaattatt
    37801 agtatatatc ttttattttt gtatctgtgt agtaatgtga taatatatca taatatttat
    37861 aaccctcttc tgccattcct tctgctcccc actggctcat accaacacca tgaccatatc
    37921 cttttaccac gaaatctatg tatccttctc caaattttat gtcaaagttt gcagagttca
    37981 acttaaaaac agttctaatg tcttttccag tcaattcttt atttcctaat tttatttttt
    38041 ctacagttcc ggcatcactt cttttagtta ttgaaacttg tttacttaaa ttattcacat
    38101 ctatcacaat agtgctatat gcccttctaa gacttttaac aaaatctgtg ttacttattt
    38161 taagtgttga cgcaaattta ggggaatact tatcataagg actttccaca gactttaaat
    38221 aaggatattt tgcagaaaat acttcttcac tattttctgt ttttcctgaa gatgtagaaa
    38281 aataaagagg aagtatcgcc ttatcattat aagttattat ttgaccttta gttcctctaa
    38341 ctgcttcttg gattttggaa tatttattct taatccattc ttcaccattt aattttttaa
    38401 gagtatcata actcttatat tcttgacaat gtttataatc agtacatact actgcatttt
    38461 tatgtttact agatttacca tgttcctgtt tatatactac atatgttcta gctgctacag
    38521 attgagcttt taaagcttct atatcaaact ctgaagacat ctcaccagct agtactccac
    38581 ataaatagtt ctccatgtcc atcttttcgg ttttccctgt tatatgatta tatacattga
    38641 taattggtgc ttttttattt acagtttcat agttcactgt atttttttct tctttattac
    38701 ctttgtcttc aatatcactt tttttaatag ttttgtttat agatactggg ctctctggtt
    38761 tttcagttaa ttctacattt ttataagaaa ctaaagttat aagtgatgga actaacacag
    38821 agcaagtcac aaatcctaac aaaacaacca atgggttctt catatactct cctccttagc
    38881 ttttaaaacc ttgtatttaa gtatatgaac aaccctatta atttataact ttcttctata
    38941 aaccaattat taatcttcta ctatttcgat ttgaccacct agtgctgtta tcttcttatc
    39001 tatatcaaca taacctcttt ggatatggta tatttctcct atttgagttt ctccttctgc
    39061 tataagaccg cataaaataa gggctgcccc tgctcttaaa tcagtagcgt ttactgctgc
    39121 accgtgtagc tcatctacac cattaacaac cgcacttctt ccatctattt ttatattagc
    39181 acccattcta ttaaattcag caacatgcat aaatctgttt tcaaaaacag tttctataac
    39241 tacaccagtt ccattggcta cagtaagcat agccataaat tgtgcttgaa catctgtagg
    39301 aaatcctgga tgtggtaaag tttttatatc tattggtttt aatacttttg gacctacaac
    39361 tcttacagaa ttgtccattt ctgttatttc acaaccagct tctcttaatt tagctacaac
    39421 tggttttaaa tgctccatta aaacattttc aacagttata tcaccttttg tcatagctgc
    39481 tgcaaccata taagttgctg cttctattct gtctggaatt acattatgtt ctgctccttt
    39541 taactcttta acacctttta tttttatagt attagtacct gcacctttaa catctgctcc
    39601 catttcgttc aagaagtttg ctaaatctac tatttctggc tcttctgctg cattctctat
    39661 tattgtagtc ccttctgcta aagaagctgc catcattatg ttttcagttg ctccaacaga
    39721 tgggaaatct aaatataatt tatttcctac taacttttct gttgctgctt caacaaaacc
    39781 atggtccatt tctatctttg cacctaaagc tttaaatcct tttaaatgta aatctatagg
    39841 tcttgttcct atagcacatc ctcctggcat agaaattttc gtactattaa atctagcaag
    39901 caatggtccc ataaccaaaa aagaagctct catctttctt acaagctcat atggagcttc
    39961 acaagttttt atattgcttg catcaacagt aagtgtattt tctttatatt caacttctgc
    40021 tcctacatgt cttaataaat ctgatataac atgaacatct cttaaatttg gtactccatt
    40081 taatgttgat tttccgtttg ctaataaagt cgctgctatt attggtaaaa ctgcattttt
    40141 tgcaccatct attttaacac tacctttaag tggattactc ttttttacta ttatcttagc
    40201 catatttttt gatctcctca taattaataa tctaatttta taattggtgt ggcaatatat
    40261 atgagtgttt ttccgtcatc ctcattatat ttaattccta tatttaaatt aattttttcc
    40321 cctaaatatt ctaattcata atcatttaat actttactat atgctgttat agataaaaag
    40381 tttacgtctt taacttcatc tatttgctta gcactcatat tatataatat tttttgtaaa
    40441 atatcatcat atttgttgtt ttgtaacctt tttgtgtatt ctccaacaat acaagcagac
    40501 acatctactt gagatgaata tttatttaac acattttcta cgttactata aataacctct
    40561 ttatgtttat atactttgtt atccaatatg tcaactacta tgtaactttc tttgttattt
    40621 ttatttattc cttttataga aatttcttta tcgctacctt ttatagtagc acataattgt
    40681 attttatcgc cagacccttt ttgattccaa tttattcctt ttttatccaa ctttagattg
    40741 ttaattattt ctataaaaat attatgaaat tctttatttg ataaattatg atttataaca
    40801 gaattaattt taacattata aaatttaaaa tttgcttctg atatttcaag agctttactt
    40861 aatctattgt atctagtatt tatacttgta tctgcataag atattgtcat tcctataatc
    40921 attaatataa aaaagcttat agctaatttt acttttttca tagtaaaaaa tcccccttaa
    40981 atatgttttt ctgtataata gaattattaa caaatttaag agagatatac tttctcaata
    41041 tgtattttta tacatttttg tatttttcat ctaataatct ctttcaaact cttcaatctc
    41101 aattttctct atccttctcc tggacttgcc aatttcttat atgtatcaaa tacatcttgc
    41161 attaattctt atatattctc ttctgtaata taaattactt agtctatact taaatctata
    41221 atctataatc tataatctat aatctataat ctattcatat tttaccaaca aaataaacag
    41281 ataatacttt tttatcaatt tccatagctc caaatgaaca tacctaagta cacttcccaa
    41341 tacacaattt acacactctt cctaataaat caaaaacacc tttgttttaa acaactctat
    41401 tgcactttca aaaactttat ttgtgttctc ccacttcaat taaatttgaa ttatcaagac
    41461 tccagcccat ccatccatca ctataaaggg aggtattttc cactcctatg acatttgcat
    41521 atgttaatac ttcagcagca cgccatccac ttccacacat aaatataagc tgtttattca
    41581 catctatatt ttccttgtcc cacatttcta aaatctcata tttatttctc attgtattat
    41641 caatattacg atattcttct agtgaaacac tatcactacc tgaatgtcca tataaagctc
    41701 ctggtatacg ccctttttta tcataatatg tatatccaga tacttttcct atatgttcat
    41761 cccaagtacg gttatctact agtataaact tatttttttc ttttagtttt tgtcttaatt
    41821 cagatgtagt aacaattaat tgtgagttaa ctggtatatc tgctccaaaa ttagtacatg
    41881 aatgttttgg attactaata aattctaatt catatcctgc tgataaccat gagtttgttc
    41941 caccattcaa aactcttaca tcttttactc ctatatatct caatataaca gctagtctat
    42001 aagatgccat aggtgtacta cttgaaacta ttacagtatc atcctttgtt aatccatagt
    42061 ctaaagcaaa cttagttaag ttatcatcat tatcaagcat ccatgttgga ggaggttcta
    42121 taatatcagt atttacatga acacttgtag gtatatgccc ttttgtatac gattcttctc
    42181 tccaactcgc ttcaatcatt tttatattct ttgaatcttc aaatgtctca ggaatttttc
    42241 catctaatat atcttttatt ataaaagcag gaactatcat ttgataattt ttatatcttt
    42301 ccattggaag attttcgtcg tctgcccatt gtttaatatc atatttatat agatatttat
    42361 atcctttttt agataaataa tctgctacaa ccaaagcatc ttttccattt gcatcataca
    42421 atactatatt tttatctaaa tcaattcttt tagttttcaa tgcttgttct aacacttcat
    42481 cttttctatc tgagtataca cttaaccaat tagcagaaaa atctactgct ccttttatat
    42541 gtccacctct ttttactcca tctaacttcc agccattata agcatcattt aagcgagtat
    42601 caactataac ccaagcgtta tcttgcactt tttcttgtaa aacttcagta gatattgcct
    42661 taagattaac aaaataatct tctttctttt cttttttaaa atcatttgtc ataatttata
    42721 ctcccaattt aaaaaaattt ttatttgaaa ttattttact aaaataaagt aattttctta
    42781 tactctatta gcttcattat attcttttat aaatagttcc ttatattctt attttaaact
    42841 actcacttta tcttatcaca aggttactaa taccttgtat tttaattttt ctcataagct
    42901 attatttttt tatctgatat tgactatatg tttattaagt actcactata ttttatatga
    42961 actatattta tcgttcccta tacctggtat ggtctatata tttatcattt tacagatgat
    43021 ttaatatcaa tctttttata aaatttatta tagcaaaaac aaaacaaatt taatatttat
    43081 ctaaaaaact catcctataa aatacaaata acaggatgag ttcttttcaa taaatattat
    43141 ctatttaatt tttaatctgt ttttattcaa ctgttactga tttagctaga tttcttggct
    43201 tatctacatc gcatcctctt agtacagaga catgataagc aagtaattgc attggtacaa
    43261 ctgctaatat tggtgataaa atatcatctg aatttggtat atagattatt ttatcagcag
    43321 ctttctcaac atccttatta tggctttgag ctattgctac tacataagct cctcttgctc
    43381 ttacttcttc catattagaa accatttttt caaataactt ttcttgagta gctatggcaa
    43441 ttacaggagt tcctttttct attaaagcta ttgttccatg ctttagctct cctgctgcaa
    43501 aagcttctgc atgtatatat gaaatctctt ttaatttcaa tgaaccttcc attgctaagc
    43561 tatagtctat acctcttcct aaatagaatg catgttcaga actaacaact gttttagcaa
    43621 cttcttttat atattcttca ttgtctagta tttcttgtat ttttgatggt atttctttca
    43681 tcttagaaat catactatca taaaattctc tagttattgt tccttttttg atagcaaagt
    43741 ctaaagctat catgtataaa gaagttattt gagtagtata tgccttagtt gatgcaactg
    43801 ctacttcagg tcctgcccaa gtatagaata catcatctga ttctcttgct atagatgaac
    43861 ctacaacatt agttattgaa agtattcttg ctcctttagc ctttgaatct cttaatactg
    43921 ctagagtatc tgctgtctca ccagattgac taactaatat tactaatgaa ttttcatcta
    43981 caaatgggtc gctatatcta aattctgatg ctatatcagt tattactggt atatttacaa
    44041 atttttctat ggcatactta ccaagtaatc cagcattata tgctgttcca caagccacta
    44101 tataaacttt atttattttt tctaagtctt ctttagaaat atttatactg tctagaatta
    44161 tatttccatt atcatcaagt cttctttcta aagtttctct tactcctgtt ggttgctcat
    44221 gaatttcttt tgacataaag tagtcatatc cacctttaga cgcagcttct acatcccaag
    44281 ttacatgaaa tacttctttt tcaacaagat ttctattaga gtcataaact gttacatttt
    44341 cgtcttttag atgaactact tctccatttt ctaagaaata aacatctcta gtatatttta
    44401 ataatgcagg tatatctgat gctataaagt tttcaccttc accaacacca actacaagag
    44461 gactatcttt tcttactgca actaattcat ttccatgttc tttacatata acacctaatg
    44521 cataagctcc tcttaatttt gatatagttt tgtatacagc atctaataaa ttaccctcat
    44581 agtatttatc tactaaatgt gctattacct ctgtatctgt ttgagattca aacttaacac
    44641 cttcagaaat taattcttct tttatttcca tatagttttc tattatccca ttatgaacaa
    44701 ctgctattgt tttggcttga ttaaaatgag gatgtgagtt tacatcagat ggttctccat
    44761 gagttgccca tctcgtatgc cctataccta aatttccatc aataggattc ttttctaagt
    44821 cttctgcaag tacagaaagt ctacctttaa actttctaat attaagttct ttttcattag
    44881 aactattaac tgctactcct gctgagtcat aacctctgta ctctagctta gaaagccctt
    44941 ctactataac ttctgctgcc tttctacttc ctaaatatcc aactattcca cacattattt
    45001 gtgtcctcct aaaaatatta tttatatatt ttaagagtta ggtcatataa gtttactttg
    45061 gcttcccttt gtccatagga ttgctcctat tatttaaaga agtctttcga tggtaaacac
    45121 accgcagagc atccgccgac aattcgatta actctgacct cgtcaactta gttcctatat
    45181 tactcaataa ttatgtctat aactaagttc tggcgcttag aaaggtgtcc tcagtattta
    45241 tatctgagaa taccctttaa attacgataa tttttcttgt ataagattag ctaagtttgt
    45301 tgctaattct tttatttgac cttcctcttt accctctaac ataactctaa ctaatggctc
    45361 agttcctgat ggtcttatca aaactctacc atttccgtct aaaatagatt ctattctttc
    45421 tatctcagtt tttatttctg gatattccat atatttgttc ttattttcat tttttattgt
    45481 tgcatttact aatacttgtg ggtattggct cattattgat gcaatttctg ataaaggttt
    45541 cttttcttgc aagattatat ttgcaagtat tagagaacta agcactccat ctccagtagt
    45601 gttgtaatct aaaaatatca tatgtccaga ttgctctcca ccaagattat atccattttt
    45661 aaccatatct tctaaaacat atctgtctcc aactgctgta gtagataaat ttattccatt
    45721 ttccttagca gctattgtca accctatatt actcataact gtaactacca aagtatcttg
    45781 tgccaattta ttatttttct ttaaatttaa ggcactcaat atcattatat ggtctccatc
    45841 aacaatttga cccttttcat ttactgcaat taatctatca gcatctccat catatgcaag
    45901 acctaagtca gcattatgtt ccaaaacagc cctttgaagt tgttctggat gtgtagagcc
    45961 acatttatag tttatattat ttccatctgg tgaactattt attgaaatta cacttgctcc
    46021 tagttcatca aacactattg gtgccacttt atatgacgca ccattagcac agtccaaaac
    46081 tacttttaat cccttaaagt cagtgcttat tattgatttt aggtagtcta catagtctct
    46141 ttgtgcacaa tgttcatgta attttcttcc tacattttca ccaattggaa gacaatcaat
    46201 tttgtctata tcgtctatat attcttctat tttcaattca atttcatcat ctaatttata
    46261 tccattctta ttaaagaatt tgattccatt atattcaaca ggattgtgag atgcagatat
    46321 aaccacacca caatcagcac catattttct agttaaatat gccactgcag gtgttggtat
    46381 tattccaaca gtaataacat cacatccaac agacataagt cctgctatta aagatgcttc
    46441 caacatatca cctgatattc tagtatcctt acctactact acttttactc tgtggtctcc
    46501 ttgagctaag acaaatccac cagctctacc aagtttatat gctaaatcac atgttagttc
    46561 tgtatttgct actcctctaa ctccatctgt tccaaaatac tttctcacta aagattctcc
    46621 tttcataatt gaaaagcttg taatttgtat tatattttta tagttcataa aatatcatta
    46681 taggcttaat ttcagtcata aaaatatttt aatacttatc agcaaaaaag acaatagaaa
    46741 taattctatt gtcttttttt tgacatcttt ttctttatta gttagttgct ttagaacatg
    46801 tagcatccat acctttttgt aaagcttctc tgtttaatgg aacgaatttt tcttttctag
    46861 gtccgaaaac ttttttgaat gcttctagta cagattctat atctacagta tcagatactt
    46921 ttaagtaagc gcctaacatt atcatgttag caactttatc atttcctaat tcagctgcta
    46981 attcatttgc tggtatataa taaacatcta catctgttct atcaactttt tcttttatta
    47041 aagaactatt tactattatt tttccaccag gaataacatc atctttgaat ttttcaaatg
    47101 ctggtatatt taataatata gctgcagttg catcatctgt tataagtgga gaaccaactg
    47161 gctcattaga tacagttact gcacagtttg ctgtacctcc acgcatttct ggtccataag
    47221 atggtaacca agaaacttct tttccttcta gcattcctgc ataagtaagt aattgtccca
    47281 tagacataac accttggcct ccgaagcctg cacatattac tctagctgta gacatttact
    47341 tcacctcctc aacttcaaca tttttgaaat ttcctaatgg atagtatggt atcatgttgt
    47401 ctcttaacca ttgtaaagca tcgtttggag ctagtcccca gtttgtagga caagtagata
    47461 atacttctac tattccaaat cctaatcctg cttgttgaac ttggaatgct ttctttatag
    47521 cttttttagc ttgtctaaca tgagctggag tatcaactgc tactctttct acaaatacag
    47581 ctcctgttaa tgtagctaac atttcactta ctcttattgg ataaccttga gtttcagcat
    47641 ttcttcctga ttgagcagta gtagctcttt gtccaactaa tgtagttgga gccatttgtc
    47701 caccagtcat accataagtt gtattgttta caaatatagt agttattttt tctcctctag
    47761 cagctgcatg aactatttca gcagtaccaa ttgaagctaa gtctccatca ccttgataag
    47821 tgaatactgt attttcagga tgaactcttt ttattcctgt agcagcagct ggcgctctac
    47881 catgagcagc ttcttgagtg tcacagttaa aatatttata tcctaaaact gaacatccaa
    47941 ctggaacaac acctacagca tcacctaata ctcctagttc ttctaatact tcaccaacta
    48001 atctatggat tataccatgt gtacatcctg gacagtagtg agtttgagta tcttgtaatc
    48061 cttcagtttt cttaaataca acagccatta tctagcacct cctgcaacca attctccggc
    48121 aataattttt ttagcttttt caactatttc tgctggtgtt ggagtcattc ctcctggtct
    48181 tccatggaag taaactggta atttaccttc tactgccatt ttaacatctt ccaccatttg
    48241 tcccatactc atttcaacag tcaatatgtt tctagcatta ggaatttggt tgaatgcttc
    48301 gaatgggaat ggccataata ctttaggtct tataagacct gcttttattc cttcttctct
    48361 taatatatca attgcgcttt ttactactct tgaagtagtt ccataagctg caaatacaaa
    48421 ttcagcatct tctgttttgt acatttcgta ttgtacttca ttcttttcca ttgcatcaaa
    48481 tttttcttgt aaatgccaac aatggtcttc tagtacttct ggctctaagt atagagagtt
    48541 tattacatta ggttttcttt ttcctttagt tccaacagtt gcccaatctt taggaggcaa
    48601 ttctcttttc ttctcaggag ctctaaattc aactggctcc atcatttgac ctatcatacc
    48661 atctgcaact accataactg gtgatctgta ataatctgca acgtcaaaag cttccattat
    48721 catatcaaca gcttcttgaa ctgtagctgg tgcgaatact ggagttctgt agtctccatt
    48781 tcctccacct cttgtagaca taaagtagtc agcttgtgaa ggttgtatac ttccaagtcc
    48841 tggaccacct ctcattacat taagtacaac acaaggaact tctgctccta ctgcatatgt
    48901 tataccttct tgctttaaag caactcctgg tgaagatgaa gaagtcataa ctcttgctcc
    48961 tgcacctgct ccaccataaa ccatgtttat cgcagaaact tctgattcag cttgaacgaa
    49021 cgctccacct attttaggta actctcttga taaatattct ggtaattcac tttgtggagt
    49081 tattgggtaa ccgaagaaat atttgcaacc agcttctata gctgcttttc caaatgcttc
    49141 gttacctttc ataagtatct tagccattaa aattccccct taaatattaa ttaaattaat
    49201 ctctttctac tgttataact acatctggac acatagttgc acaacttgca catcctatgc
    49261 atttttccat ttcaaaaaca gttgctgggt tatacccttt tttgtttatt acatttgagt
    49321 ctaattgtat gatttttact ggacatgctt caacacacaa tccacaacct ttacaacgtt
    49381 cttgattaaa agatactttt cctttagcca tttacctaag cctccttaaa ctttctatat
    49441 atttgagctc aaactacatc cagtcttctc tcatatataa ttttatagga aaaatttctc
    49501 cttctaaatc ttttggtaac tgttcaacaa gattttctaa acatgcaaca tatcttatcg
    49561 gtatattaca tttttcagaa acttcttttg caactttctg acctcttaaa acatcatcaa
    49621 tagtagtaaa cctaataaga tgagtattat taattagacc tgttaccttt aatttagaag
    49681 atttttctat ttcttttata tattggataa cttcttcaga agtttgagtt ttctccctat
    49741 ttgcatttat tacaaaaagc atatcataat cgccttcttt taacaaatga ctaaatcttc
    49801 ctataaccct agcacctaca ttatctccac ctaaatctat aacagaattg tatgaatggt
    49861 ctaccatagg agacattacc tctgctgata ctgctggtaa atctaatgtt ggagcattaa
    49921 ttgagctatc tattggttgt atacctaagg atttcattaa ctctttcttt tctctagttc
    49981 taaagtatac atttaccaca tctaaatcgg ctatagcaac tttgccagaa accatatctc
    50041 ttaacttaac aacatagttc atcgcaaatt cacttttacc acttccatag tgaccagtta
    50101 tgattcttat tcttttatca ttagttatca taaacttgag cctcttcttc accagttaaa
    50161 actctaagtc caccttgagc taatgcaatc atttcatctt cacctggata aacttttaca
    50221 tctgctataa atttaactct atctgcaatc atttctgtaa acatttttga atatgcgatt
    50281 ccaccagtta ataatattgc ttttacatct cccttaagaa ctgcagcact agctcctatt
    50341 tctttagaga tttgatatgc catagcttca tatgctaatt tagctttttc atcaccagct
    50401 tcaattcttt cttcaacttc tctagcatca ttagtgttta agtatgcaac taatccgcca
    50461 ttacctttta ttttcttttt aatttcatct tgagtatatt ttccactaaa gcacattttt
    50521 actaatgcac ctactggtag tccaccactt ctttctggag agaaaggtcc ttctccatct
    50581 aatgcgtttg caacatctac tattttacca tttttatgag ctccaacaga aactcctcca
    50641 cccatatgtg caactataag atttatatct tcatatttct tgtttatttc tctagcatat
    50701 cttcttgcta ttgccttttg atttaaagca tgtactacac ttgctctact tatttcaggc
    50761 ataccagaaa ttctagcaac atcttctaat tcatctacaa caacagggtc tactatgtat
    50821 gaaggaacat ttacttcttc acctatttgt tttgctatta ttccacctag gtttgaagcg
    50881 tgttctccta aaactcccac ttttaaatct tcaatcatag cagcacttac tgaataagta
    50941 ccacctttta taggtttaag aagtcctcct ctacctacta cagcatctaa ttcagatgtt
    51001 tttactccac cttcttttag agcttcttct attacttgtt tacgaaattc aaattggtca
    51061 gacaccttct catattttcc tatttcttct gaagaatgtc ttaaagtttt ttcaaatact
    51121 aaatcctcat tatcaaatac agctatttta gttgatgtcg aaccaggatt tattgttaag
    51181 attttaaata ttttgctcat ttgcctattt cccccttaaa attatgcctt tgctgccatt
    51241 aaaacaccta aagctattga gtttagttta gtttcttcac tgtctgctct agaagttaat
    51301 attattggtg ctttagcccc aactataact cctgcatttt ttgattttga gaagaatacc
    51361 aaagctttat ataatatgtt accaccttca atatctgggg ctaataatat atcagctctt
    51421 cctgctacag gatgatttat acctttatgt ttagctgctt ctaaagatac tgcattatca
    51481 attgcaaaag gtccaccaac catacaacct ttgatttctc ctctttcata catttcttct
    51541 agttctttag cttcaactgt atctttcatt tttggattta ctttttcttt tgcgcatatt
    51601 gcagcaactt ttggttcact tatatctaat gaatgtgcta ctgtgcaagc attttctatg
    51661 atttgctttt tagtatttgt atcaggagct aagttcatag ctgcgtcagt tacgaaaaat
    51721 aatctatcat atccctctac atcaaatact gctacgtgac ttaatacatt tccagttcta
    51781 agacctactt ctttatttaa aactgctttt agtattattg atgtgtctac taagcctttc
    51841 attaccatgt cggcttttcc ttgtgaaact aattcaacag attttagaga tgcttctgct
    51901 aaatctttta tatctatcag ttcataattt tcgatatcca tgtctatgct ttttgcaatt
    51961 tctttagtct tttctatatc tcctactaaa atggcatttg ctattttttc ttttctagcc
    52021 atttcaactg ccattaaaac ttctttatct tggcaacatg ctactgatat agttttaggt
    52081 cctctttctt ttgcaaactt aattacttct tcaaaacttc tcatgcattt ccacctcatc
    52141 ttgaattttt tgaaatagaa ctttttatat ctcaattaaa ttataactcg ttcagcaacg
    52201 ttttcctaga gataattgaa atatttaatt caaaatattt atttaaatct atttatcagt
    52261 cttttttcat atatctagcg ctttttagat ttaacaaata tctcattgtc cttattttat
    52321 aatataacta aaataaacaa gatgcaacaa aaacataaaa ttaacaaact taattttata
    52381 ggtttttttg tcgcatcttg taacaactaa atattcgaaa tatttgttca ttccacttca
    52441 acaatattag gttctatatt tattttttta aattgatatg ttgtttcata ttttatttta
    52501 tatttactat cttcctcagg accttgtgat aaatcaatat ataatgaaat atctttttta
    52561 tttaacttac tcaaatcctc cattgactct acaacaactt ttatatctac atcagaaatt
    52621 acatttggat tatccatatt tgttgggata tttcttaatt caatatctcc cgcattatat
    52681 aaaaattctg cactcaattg ttttgtatca tttaatttaa ttgttataga gctatcctca
    52741 agagttatac cctctggaat ttctaagcta acttcttttt cttcaccatt agccaaatca
    52801 gctaagtcaa taggttttgt cttaatataa cttattttgt ctatatcttc tttctttcct
    52861 tttattgtaa cttgttcctt acttaattta tagtttttca gtacatcatt atctttatta
    52921 tcatttagac ttactcttat tgggacaatt ttttccttca atagttctat ctttgcagtc
    52981 acaaaggatg aacttaatgt tactccttca accttagttc catcactatt taatggtatt
    53041 aattgcaatt ttttagaaaa atcatctgtc tcattaccaa catctagatt agctcttaca
    53101 cttttgactt ctttaactag agttcttgga cctgatacat cgacaaattc cttactaagt
    53161 tcaattttat ttatatttct ttttgaattt ccacttactt ctacctttat atctcttttt
    53221 tcttttatgt ttttttcaag atttactact aaaacatcat gcttaaattc tagagtaaca
    53281 ccttgaggaa tatttgcttt taaatatact tccttctgtc cttgtattgg gtcttcaatg
    53341 gttccatata catgtatatc ttctttttta acactttgta cctttgataa actacctttt
    53401 atatatacat ctgctgttaa tttttcgtct ggatatataa caagattttt atcctttaaa
    53461 tcactcatat tacttataga tacaggtata tcttcaaacc ctttagtttc ttcagggtca
    53521 actacagcca taacatacat ccataatgca attgcactta aaaatgatat tatttttatt
    53581 ttggtattat tttttagtct atttatcatt taaatatacc acctttgaaa aaacttcttg
    53641 tttctgtatt tgtttttaaa ttactacgta atatattcat cattctttct ctagaaatat
    53701 ctctatataa cttacctgct ttagcaattg atacgccacc tgtttcctct gatacaatca
    53761 aagttataca gtcagacacc tcacttaccc ctattcctgc tctatgtcta gtacccaaat
    53821 ctttacttaa atccttactt tctgtcaatg gcaaaaaaca tgcagctgct tttaccttag
    53881 aatctctaat tacaacagct ccatcgtgta atggtgtatt tggtataaat atatttatta
    53941 atagttgcct agaaatttca gcatcaataa tagttcctgt atttattata tcacttattc
    54001 tagtttctct ctccattatg ataagagctc ctattttttg tctagaaagt gaatataaag
    54061 cttctacaat ttcttctata tttctattga gagtttcttc agaagtattt acattctttc
    54121 caaataaatt aaactttgct cttcctatat gttcaagtcc tgctctaaat tctggttgaa
    54181 aaattataag agcagctata actccataat ctaaagcttt aagagatatc caataaacgg
    54241 tatgcaattt aaaggtgtta ctaagttgag ttgctaataa aagaaatatt atacctttaa
    54301 acacttgttc tgctcttgta tcttttataa acataaatat tttgtaaaaa atatacgcta
    54361 ctatagatat gtcaattaaa tcatatatac tcattcttaa tattatatta aaaaatccat
    54421 ttaaaaaaga atttatatct aacacagttt tatcctcctg tttgataact tcttaattat
    54481 ttacactaag tattatacta tataaatcta actctataca aactatttaa cttttatgta
    54541 aataattcta gttttatatt tggagattgt taaataatct ctaaacacat taaaaatatc
    54601 aacttaataa atacatattt cttattaaag ttagttttta ctcaaataac tcaaaccatc
    54661 aaggcgcgaa tacaaaatag tactcgcgcc t
//
LOCUS       DAEHWM010000018        52240 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.019, whole genome shotgun sequence.
ACCESSION   DAEHWM010000018 DAEHWM010000000
VERSION     DAEHWM010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 52240)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52240)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52240
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.019"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(76..270)
                     /locus_tag="KNP36_001092"
     CDS             complement(76..270)
                     /locus_tag="KNP36_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0872980.1"
                     /translation="MINYMVEIIYSEKISEVENMLKIENIQYEFTSRDGFIFFGFYDM
                     TDAYRFETLCSDEKIRFKRI"
     gene            complement(644..2263)
                     /locus_tag="KNP36_001093"
     CDS             complement(644..2263)
                     /locus_tag="KNP36_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HBF0872981.1"
                     /translation="MNIVISLIGGLGLFLYGMSLMGEGLQKSAGDKLKKIIELLTSNV
                     VMGVLVGTVVTGIIQSSSATTVMVVGFVNAGIMNLSQAIGVIMGANIGTTVTAQLVSF
                     NLEGIAPIALGIGILFYLFTSNQKTKHLSEILIGFGILFTGMEFMKDAVAPLAEYKAF
                     TDALLYFSKNPVLGILAGFAITGIVQSSSASMGMLIALASQGILPLSSALPILYGDNI
                     GTCVTSLLSSVGASRNARRAAVMHLSFNVIGTIIFMLVLNKPISAIVTHFDPTDTARQ
                     IANAHTLFNLTNVIILLPFSKYIVKLANRLIPIKETESEIVNNTKYLDERMFSTPSIA
                     LGNTVQEVVRMGHKATNSLEHSIAGFLNKSNEDINKAFESEKVVNKLQKDILNYLLKL
                     SKEPLRDDERFRTDLLFNTVNDIERVSDHAENIAELAMSVKEMNISFSDSAIREIYEI
                     YNKTITNFKDALIVLDVKDFELANKVLEVENEVNYLEKTFRNSHMIRLNNGSCTIDAG
                     VLYLDLLTNLERISDHSTNIVKQVLKLKQKI"
     gene            complement(2572..2790)
                     /locus_tag="KNP36_001094"
     CDS             complement(2572..2790)
                     /locus_tag="KNP36_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872982.1"
                     /translation="MFFSLFKKKSGYTFTNFLSKVRVEKSKKYILKKDLSILDVAVLI
                     GFNSQNYYSIIFKKFNNFTPIEYKNIYN"
     gene            3083..3274
                     /locus_tag="KNP36_001095"
     CDS             3083..3274
                     /locus_tag="KNP36_001095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872983.1"
                     /translation="MERLMELIERKFLKDVELLELEDIENVIECKMTQPYNAHYNEYL
                     VKVKNGDEVEEYFVYLKHR"
     gene            complement(3363..4175)
                     /locus_tag="KNP36_001096"
     CDS             complement(3363..4175)
                     /locus_tag="KNP36_001096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mrp/NBP35 family ATP-binding protein"
                     /protein_id="HBF0872984.1"
                     /translation="MADCNSCPSKGNCNSQSNCSIENNPNNKFGKIIGVMSGKGGVGK
                     STVTALLANKLNKMGYKVGILDSDITGPSIPRLMGVKNVKAYSDGSYIYPVENSNNIK
                     VMSINLMIDDENEPVVWRGPLLGGVVKQFYTDVLWEELDYLLIDMPPGTGDVALTVMQ
                     SIPISGIVMVSVPQDLVSMIVSKAVNMAKKMNINVLGVIENMSYIQCPDCSKKIKLFE
                     GESTEKFLDDLDLELLGELPMTKEIIDITHNGVTEISDDLDSILTNVVEKIK"
     gene            4597..5748
                     /locus_tag="KNP36_001097"
     CDS             4597..5748
                     /locus_tag="KNP36_001097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004452985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0872985.1"
                     /translation="MELRPRSAKLEEFDKVIELINYVFRISRNHKPTMMEEFPLLLSK
                     NNIENMIIISEDDKVISDVNYLIQDVSIQGNRLKVAAIGGVCTHPDYEKRGYSSKILD
                     KVEEKMFYDGVDIVIISGTRSLYSRRNCSLVKSFYKYTIKPEDVKIAYEIVEFDETNF
                     EKDNDLDKMIELYNQNSTRFIRTRDEFQKLLHAATIAWGPIGYKKVFIKENNNIIGYL
                     IIRTIKKEDSTVGEVAEIGLNSVNVENILKYVANKFGLEYLNYKVHVKNLKDQLKCNG
                     TKSLDYQQGTMKIINFTKLCDSLRSYFSQYVDFELLKYMEFKQVENKYIIKYKEEELV
                     IENLDKLNKLFFEKNEEQYNEFKHLKNIYEFATKAFPVDFPWTANLNYQ"
     gene            5866..6504
                     /locus_tag="KNP36_001098"
     CDS             5866..6504
                     /locus_tag="KNP36_001098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423639.1"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on
                     a cobalamin-like analog; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin-dependent protein"
                     /protein_id="HBF0872986.1"
                     /translation="MDILDDIAECILNMGVDNIENLVKIAIDKNIDVEDIYEYGLNKG
                     MIGALDKFENKEYYLSEVIVCTDALNKGINLLKGTGKVKKKSKGVILMSVVEGDTHEI
                     GKNIVKVMVEATGYKVIDLGVNRKSEDIIEEAIKNNVDIIGLSSMMTTTMENMKSVID
                     ELNMIEIDKRPKVIIGGGPVSMEFAEEIGADGYSSNAPKAVKLINKLIGGEV"
     gene            6505..7527
                     /locus_tag="KNP36_001099"
     CDS             6505..7527
                     /locus_tag="KNP36_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uroporphyrinogen decarboxylase"
                     /protein_id="HBF0872987.1"
                     /translation="MFSDMTLLQYINSEDRGFFLPDMGTNGLFLINKKAYEVYDSVDL
                     QLELAKTMDKYFESDFIYSFCDGITFCETLGLETLRPDYDFPSVLTHTITDRDKLRKL
                     DVPDPYTSGRMPLNIESLSVISKSIKKPLYESIQGPFTLAGQLAGATQLLRCIITDKK
                     FVEELLEFTTELVRRYAVAANKAGAKYISIAEPTSVTLSKDRFDEFIVKNLNKIYNEL
                     DCWKGMHICGDTRELLDNMLSCNIDAVSLDQILDYEEIAPMIPRDIVLIGNLDPIKLL
                     GRSKPDKIRRETLKLLKKMRRYDNFLCDFGCNCLNTTPVENLQAAIKAGRISYKELDR
                     IDIDEL"
     gene            7517..8137
                     /locus_tag="KNP36_001100"
     CDS             7517..8137
                     /locus_tag="KNP36_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872988.1"
                     /translation="MNYNSNKNKYLLKDINLDDIFIDKNIVLKFLGYGNRKAPDTISK
                     IVEREIRNINDILDIKIYISEVDINKTPKECKKAFAVLYTIGDKIDIKMNDYMENCNM
                     MAGLALDKIGIVCLDYINEKIKMYLKGKYDSLKISHEIYPGDKDFEVERQKDIYNYVK
                     NKYNSIEIEINDYHQLSPIKSVAMLILMGDEENLESRCSKCPRKCF"
     gene            complement(8261..8947)
                     /locus_tag="KNP36_001101"
     CDS             complement(8261..8947)
                     /locus_tag="KNP36_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HBF0872989.1"
                     /translation="MKTYKFIFFDADDTLFDFKKSESHAFKKLLSEFDLEFNFENYIE
                     SYRNISDKLWLDLEKNIITLNELKLLRFELFANKISLDVDSETLSKMYLNFLGECTFL
                     IPGAIDILQYLKKKYTIVIITNGISAVQNKRLENSKIKGYIDGMVVSEELKISKPNPE
                     IFKYALKKFNCHDKSSALIIGDSLTSDVLGGINSGIDTCWLNSNNSINYTNHIPTYEI
                     NTLIELKKLL"
     gene            complement(8961..9506)
                     /locus_tag="KNP36_001102"
     CDS             complement(8961..9506)
                     /locus_tag="KNP36_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0872990.1"
                     /translation="MNDLNLGEKIAEVRKKQNLSIRDLAKLADVTPSLLSQIERGLAN
                     PSVNSLKSIASSLNVPLFTFFVSEVDKKNLIVRHDNRKKVILPGSKEVIYEILIPDSS
                     GNLEFAIMDLAPNTSSCVDRITHNGDEIAYVLEGEVKLFMDDDEFTLSKGDSVKVPLG
                     TKHKWQNDSNSESKVIFAVIL"
     gene            9734..10981
                     /locus_tag="KNP36_001103"
     CDS             9734..10981
                     /locus_tag="KNP36_001103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBF0872991.1"
                     /translation="MQITTFGAIFGLLIAIILIIKKFQAVYSLMLGAFIGGLVGGANI
                     TQTVDFMANGAMNISPSILRALASGVLAGSLIKTGAVDKISEQIVKIFGEKRALFSIA
                     ISTMVLAGVGVNLDVSIITVAPIGLYIGRKLNYSKLSILLAMLGGGKAGNIISPNPNT
                     IAVADNFSVNLSSVMMANIIPAIIGVVITVILASILINKGNKVQSYEILEQREDLPSL
                     FKSLCGPIIAIFLLFLGNVSPIVIDPMIALPIGGIVTLIVTGNLNNSREYLTFGLSKM
                     QGVCILLLGTGTIAGIIQMSELQQSTIGALQFLNMPQFLLAPVSGILMSLATASSTAG
                     ATIASSTFHDAIINGGLSPISGASIVNAGSSVFEQLPHGSLFHTSAGSINMDIGERFK
                     LIPYEALIGIVMTIISTSIQLVL"
     gene            11068..13062
                     /locus_tag="KNP36_001104"
     CDS             11068..13062
                     /locus_tag="KNP36_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBF0872992.1"
                     /translation="MNKKKIVIIGIIYSFLVVFSLTNMYVNMEYNLNVFEYIKKSLPF
                     TEEEKKWLEKHKNLIYSSDQSSPPLRYKGKEDGQYKGIIVDLINSLSIQIGRDFYFKP
                     NNWWKESFVNSIDDSIKFFDLIPSKERANKFIFTDPIYTLSANILKDKKSQDINSYMD
                     LKGKTVAIPEGDYSINFLKQKIQDINILLTPDIKTGVNHLMSGKVDAVVGDEPVLRYY
                     INNYGLSNKYSVLSNPIYTKKAVLAVPKQYEELVSILNKGIFKLQKNGVYKDLKKKWY
                     STYNEVDDILYERGIVPSIYLFIGIILISIYVFYSYTYLLKIEIKRKTEQVIENKKTL
                     EATFNSITDIIMLVDENNNIVESNKVLYDFMGEMSYKIADLISMIKGVIENTFSENTN
                     KTSEIEIHNKILKINTFPVEYKKNNTEYIVVLIKDITNDKIVEAKLLRENKMISIGQL
                     ASGVAHEIRNPLGIIRNNCYLLKDNVTMEEVNDCVKSIESNVDRASNIITNLLNFARI
                     SDDNLEHINIKNFIENIVKLQYKMLQLKNVEIKIDCEHNLICYINGESLKHVFINLIS
                     NSIDAIHQDGKIIIYCYEKNHCLFIDFKDNGEGIKEDVLKDIFNPFYTTKPIGEGTGL
                     GLYITYNEIKKNNGDISVESKLGVGTCFHIKIPLNKEVTI"
     gene            13062..14384
                     /locus_tag="KNP36_001105"
     CDS             13062..14384
                     /locus_tag="KNP36_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="HBF0872993.1"
                     /translation="MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDK
                     NYDLVLSDVMMKNMDGVQLLDRIKSINRDIEVILVTGYGSIENAVDAMKRGALSYFIK
                     SNPIENLLEEVEKVKASKISVSVQKNNFEFTLESKNRDFNNIIKIAKKAACKDVNILI
                     LGESGVGKDILARYIHSISPRKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSR
                     KGRFELSNKGTLFLDEIGDIPLNVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNK
                     EPKVEISNGNIREDFFYRISTITITIPPLRKRREDLTTLIEFFLNKYQIEHDKKIHSI
                     DKEVKDFLLNYNYPGNIRELKNIINRLVVLSEEGNLSKDNLNLISNNVYIDDKISIRP
                     LREIRKEFECEYIEKVLSLCGNNISNTAKKLEISRRQLTNKISEYNIK"
     gene            14663..15949
                     /locus_tag="KNP36_001106"
     CDS             14663..15949
                     /locus_tag="KNP36_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006807454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase component B
                     subunit"
                     /protein_id="HBF0872994.1"
                     /translation="MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIV
                     SVNVELARPGESIRIAPVKDVIEPRVKIGDESKIFPGIINKVKTVGSGRTHVLLGACV
                     VTCGNIVGFQEGVIDMSGPTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKI
                     GAYVGEAGREVEPDEVIVYETKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVD
                     AKQIVPTFMYPTEIMDGAIISGNCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGV
                     ILTNENVFLVDKERSSDMVAKLIEFLGVDGVLVTEEGYGNPDTDLMMNCRKCSEVGAN
                     VVLITDEFPGKDGKSQSIADATKEADAVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIG
                     GYKGCLNEDGSMDAELQIIIASTIANGYNHLTARYY"
     gene            16035..17342
                     /gene="grdB"
                     /locus_tag="KNP36_001107"
     CDS             16035..17342
                     /gene="grdB"
                     /locus_tag="KNP36_001107"
                     /EC_number="1.21.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:17082..17084,aa:Sec)
                     /transl_table=11
                     /product="glycine reductase complex selenoprotein B"
                     /protein_id="HBF0872995.1"
                     /translation="MSKIRVVHYINNFFAGIGGEEKADIPPEKRAGVVGPGIAFQSQF
                     NDDAEIISTVICGDTYFGENIESATQELLKMIKEESPDLFIAGPAFNAGRYGVACGTI
                     CKAVEEELNIPVITGMYKENPGVDMFKLDLHIVSTGNSAASLRKVVPIMTKLGLKLVR
                     GEEIGPPEEEGYIMRGIRKNFFHELRGSERAIDMLVKKMKGESFETEYPMPEFDRVTP
                     MKPVKDLSKIKLALVTSGGIVPIDNPDKIESSSATKYGIYDLTDMDSMSNKEFTTIHG
                     GYDRAYVLENPNLVVPLDVVRELEKEGVIGELVDYFITTTGTGTSVGNSKRFGEEFSK
                     KLLEDDVDAVILTSTUGTCTRCGATMVKEIERAGIAVVHICTVVPISLTIGANRIVPA
                     VGIPYPLGNPMLGEEESKKIRKNIVLKALNALTEDIEEQTVFE"
     gene            17619..18350
                     /locus_tag="KNP36_001108"
     CDS             17619..18350
                     /locus_tag="KNP36_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0872996.1"
                     /translation="MIRKKVYILISIAICDDESYMLNHLKENIELYMKQKNLLYNIEL
                     FNKVEDLLCNHEKFNIVFLDIQMEEINGMQAARKLRSYGNECFIIFVTVLNEFVFDAF
                     EVDAINYLIKPLSNEKLYKTLDKIVTKLDDNESNYITIQKGYSYWKLKLADILYCEVI
                     KRKIYVHLKKETVDYYETIENLERSLPTNFFRCHRSYIINLQYVYGYENGNAVMESGD
                     RIPVSRLRQQIFSKVMLEFMKNRRI"
     gene            18352..19710
                     /locus_tag="KNP36_001109"
     CDS             18352..19710
                     /locus_tag="KNP36_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0872997.1"
                     /translation="MINLFSSDLFLKYSFFFSFIVYRILMVIVQYYFLINFTNFNSKF
                     WCFILYSIISIFLIIINTYFNLYNLFSSQILFFLMTFLFVKYIIKQSTVLSIVSTLLV
                     YLIEQLVYGFTAPLNYLIFTSDINTDIYKFDINMGLSSLITIIIAGFIYWYSSKKFNI
                     KVMNFDKYIAILMIPLLLIILFMQSFEYSSNINIDTSLGIVKLLLNTSITEEIQAFLF
                     SIIGTICVFFSLFTFKKLIQALEDDKERAIMNQQIHAQKNYIEEAKSRLSQTISFRHD
                     FNNHLAIVNGLLKKDQILKAQDYLNKLEKVTSDLSFSCNTQNIVIDALFNNKLSIAKQ
                     LGIEVDCEVIIPQSTNMNDFDLCIVFANAIDNAIKACRVVDKQNRYLKLSTKLEGGFF
                     MIEIKNSYNPINNYTSGSGIGLLNIKEIAKKYQGAISIDKTSDYFQINVLLVISLHCA
                     SI"
     gene            19749..20234
                     /locus_tag="KNP36_001110"
     CDS             19749..20234
                     /locus_tag="KNP36_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872998.1"
                     /translation="MYLKRESLIYRNEEVTKMKVGNINGQAPITNGLDSCQSEVQGLE
                     QKKKALQDEIEKVRSDKSIDGETAKLKIEALKKEMEEIENKIQELKGNKGKKTNKEEN
                     NVSEVNNNLLERKKEPSNNENVKQLYDVFERSNVDEQWDNTYRVLQDDKNLKVKFNRP
                     I"
     gene            complement(20497..20733)
                     /locus_tag="KNP36_001111"
     CDS             complement(20497..20733)
                     /locus_tag="KNP36_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0872999.1"
                     /translation="MLLTHIYFNGQFKQTIELYKQAFNATVKTLIEDSCYLLIVHNEI
                     VIHNKFLILNDFGNKNGVSISEGYQPTYKIQTAS"
     gene            complement(20889..21113)
                     /locus_tag="KNP36_001112"
     CDS             complement(20889..21113)
                     /locus_tag="KNP36_001112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBF0873000.1"
                     /translation="MTVYNLKLGQKGIIDNIAGNEKLMKRLLALGLIDGTEVEVKKIA
                     PLNDPIVIRFRGFDLAIRKSDAKNINLKNN"
     gene            complement(21210..22463)
                     /locus_tag="KNP36_001113"
     CDS             complement(21210..22463)
                     /locus_tag="KNP36_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:glutamate symporter"
                     /protein_id="HBF0873001.1"
                     /translation="MITLSFDIVQTLTLSIFFFLIGNLLKNKVNFLNNFCIPAPVIGG
                     LLFCFLNLFFKYFNIADISISGNLMPNFITFFFTTIGLEISINLIKKGGSVLFRYWIL
                     CGVLAFCQNILAITISKIIKLEPLLGLMCGNVSMEGGHGYSAAFGLTIENLGIEGAVG
                     VGLSAATIGLIMGGILGCPVAKFLINKYKLKPSSNIDLSIPRYNRNLKRFGSKFFRNK
                     NRIKNNNFSETITPSVFLEQVLLIFICINTGEIISRCFYITFNILLPSVVTCMFSAVI
                     FRNLNDKINILELNFKLIDFLKELSLGIFLTLSLMNIDLFELSTLLPPILLIVTFQVI
                     FIILFSIFICFRVLGKDFDSAIIISGLIGHGIGATPNALANMSSLTQKYGDSPKAFLV
                     VPLVSGFLLDAISIPCILFFINILT"
     gene            22723..23712
                     /locus_tag="KNP36_001114"
     CDS             22723..23712
                     /locus_tag="KNP36_001114"
                     /EC_number="3.5.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosine deaminase"
                     /protein_id="HBF0873002.1"
                     /translation="MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKK
                     LAKVSFNCTSLDEYLEKFDLPLKVMQSKENLKRITFELLEDASRENVKYIEIRFAPLL
                     HTQKGMSVKNIIEGIIEGIREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNK
                     GVVAVDLCGPEKEGFCKEYKDVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRI
                     GHGVKIKDHKKAYNLVKDKKILLELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINT
                     DNRTVSDINLSSELNVIFDTFKLGLEDYKIIYRNAVEASFADKETKEYLNSLI"
     gene            23784..24524
                     /locus_tag="KNP36_001115"
     CDS             23784..24524
                     /locus_tag="KNP36_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EcsC family protein"
                     /protein_id="HBF0873003.1"
                     /translation="MKDYEDVVYIKLVKKELEEWKKNILKKPSIFDKASKGIQNKFNG
                     VLPDKYHEIITSSIKVMTKTVLFGYKYATKPSLRNMSLEEREKLVLEKAKTYKTTAMI
                     EGAGTGAGGILLGLSDFPLLLGIKVKFLYDVASIYGYDVKDYRERIYILNILQLAFSS
                     QQHINKTFKLMNNWDEYVNSLPEDINDFDWRTFQQEYRDYLDLAKFLQLMPGIGAFVG
                     FYVNGKLIDKLCETAVSAYRLRIRELKL"
     gene            24724..25875
                     /locus_tag="KNP36_001116"
     CDS             24724..25875
                     /locus_tag="KNP36_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="HBF0873004.1"
                     /translation="MTNLPKQFDSFNEARQKGFINAKELKESGKKMVGVFCTFTPVEI
                     PMAAGATVVGVCGVSEEPIPDAERVLPRNLCPLIKSSYGHAITDTCPYFYFSDLLIGE
                     TTCDGKKKMYEELAKVKPTYVMHLPNTSKGEFAYKLWKDEMIRLKEEVEKSLGVTITE
                     EDIRTAIKDKNEERELLKEFYALGKLQPSALTGLELHNVLYQAGFKFDRAELKHSLRK
                     VIDDMKERYEKGECPVQKDKPRILITGSPIGGISEKIVKTLEDAGASVVAYELCGAIR
                     SNDLLVDEEIEDVYDALTQKYINIGCSCMMNNDNRIELLDRIIDEYNVDAVIDVVLQA
                     CHTFNIESYRIREFVTKEKNKPFMSLETDYSKSDTEQLRTRFEAFVEML"
     gene            25900..26655
                     /locus_tag="KNP36_001117"
     CDS             25900..26655
                     /locus_tag="KNP36_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyglutaryl-CoA dehydratase"
                     /protein_id="HBF0873005.1"
                     /translation="MFSIGVDSGSVATKGVLFDGEKIIKKIIIPTGWSPKSTSKQVYE
                     LLSSEIDKKDIKKVVGTGYGRGVMDFADKKVTEITCHTRGIYFLNKNIRTILDVGGQD
                     SKVINLDRDGNVFNFIMNDKCAAGTGRFLEITSNLLGSDIESIDTLAKGYEPVNISSM
                     CTVFAESEIVSLLAQNISTGEVAAGILKSIANKSTSMLARGEVIDEVAFTGGLAKSKE
                     LVKMIEEILGKKIFIAEDTQIIGALGAAVIGFR"
     gene            26847..29234
                     /locus_tag="KNP36_001118"
     CDS             26847..29234
                     /locus_tag="KNP36_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding cysteine protease Cwp13"
                     /protein_id="HBF0873006.1"
                     /translation="MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEY
                     SETYKQYLNDAKNGRTEKYNGIIPNPYQLEGTQIQSKGRTAPTSYDPRKLGLMTSIKN
                     QEDLGICWDFAAMATLESFLKLNNYGDYDLSEEHLRWWASDGEYGWSVNDMNGALNYE
                     AMGYLTSWSGPKLEKDIPYNGRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTK
                     NAILQYGAVTSGYYEDIKYQSDDQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANI
                     RPSKNGAWLIKNSWGDYNSEGGYFWISYEDKTLMSDIDNFSIKGGKKPNDDEKMYQHD
                     YASIVPLISKKITAANVFDFNRGDETLKSVMFLTESIGAKYEVYYAPVVNGIPQENNM
                     KKLKEGTAQYSGYITVPIDSFDIPEGKGAIVVSIEGKNGESTIGSESNVPGYDTFKAK
                     ANLGESYIIDNTGKFFDINRDSNFYPCNFTIKAVTEKSSGESIPNESLIGSDRYETAI
                     KVSQNGFNSSENVVLVNGSSIVDALAATPFTSAINSPILLTQKEALNSKTKAEIQRLG
                     AKKVYLIGGENSISKEIEQQLKSLNISIERISGSDRYKTSLLLAQKLNGIKNVSQIAV
                     VNGVKGLADAISVGAAAAENNIPIILANEKSELQGADEFLNSLNIEKSYIIGGTASLS
                     NNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNAFVVKNGIKNQNDLIDGLAVG
                     PLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGANKNAFKELVKLKSAK"
     gene            complement(29465..29698)
                     /locus_tag="KNP36_001119"
     CDS             complement(29465..29698)
                     /locus_tag="KNP36_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase"
                     /protein_id="HBF0873007.1"
                     /translation="MATTTKNRFYDYVQENLNKYVEVHSYFSSCPLYGEIIEADSLSI
                     TLCSRYIDESNPTLNETYTLYLPLSSIISIRTL"
     gene            29987..30577
                     /locus_tag="KNP36_001120"
     CDS             29987..30577
                     /locus_tag="KNP36_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0873008.1"
                     /translation="MPKSYSDKEREYIIKRLKEEARLCMEQYGIRKTTVDELVKRVKI
                     PKGTFYLFFQSKELLFFEVLRDIHDSIQKEILYEINRVDESITCEQLTDIFMKFYRMV
                     DSTSILNLMINGEFEILVRKLPDSIIEEHFRHDDFEIGEIISCIPNAKNKDIESFSGA
                     FRAVFLTMLYKREVGSNCFEDALRLMINGLVIQLME"
     gene            30691..31536
                     /locus_tag="KNP36_001121"
     CDS             30691..31536
                     /locus_tag="KNP36_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873009.1"
                     /translation="MIKVDDLSFSYTERDFLQNINFGVGKGEILGFLGPSGAGKSTLQ
                     KILIGMITNYGGSVIVNGVESKRHSNKFYENIGVDFEFPSLYEKLTAIENLKYFGSLY
                     SKKLLSIDELLKSVGLENEANKRVSEYSKGMKSRLNFIKALLHNPDILFLDEPTSGLD
                     PSNSKVMKDIILSEKSKGKTIILTTHNMLDATELCDRVAFIVNGKISALDTPHNLIMS
                     KGAIKVRYTYFDNGEKTSECFLNNTANDKNLNMLIEKNKLLSIHSSEPTLNDIFIEIT
                     GRNLQ"
     gene            31533..32216
                     /locus_tag="KNP36_001122"
     CDS             31533..32216
                     /locus_tag="KNP36_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873010.1"
                     /translation="MRLKNLILGDIKFQFKYGFYFLYLFLSIIYICIINVFPTFMREK
                     IAIIMIYSDPAAMGLFFMGAIVLLEKSQRVLNSLAVSPVKVSEYILSKVISLGVISSI
                     VAMFIAITLNLDNIIISTIGTFFSSIIFSLLGLILASKASSLNQFIVLSIPIEIICFI
                     PPILNVLLDTKSYANLYPFNICISLISGDKNFIMINILILISIIIIIYFITYYFICSS
                     WKKVGGVKL"
     gene            32213..32929
                     /locus_tag="KNP36_001123"
     CDS             32213..32929
                     /locus_tag="KNP36_001123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873011.1"
                     /translation="MIKIINAFKQEFEQIKRDAMLFIVCVSPILCGVFIKFGIPLIQN
                     ISLNKFYYQLNLEPYFLMFDLLLAFITPFMFFFASTMVILGEIDDSISRYLIVTPLGK
                     TGYLISRFGIPGILAFIITMILLIFFSLTKISFLLNLSISLLVLLQGIIISILVISLS
                     SNKLEGMVITKFSGVFMMGILAPFFILNKAQYILFFLPTFWISKAFKEDNYVYMFISI
                     VISLIWILLLFKKFSKKIVK"
     gene            33026..33289
                     /locus_tag="KNP36_001124"
     CDS             33026..33289
                     /locus_tag="KNP36_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873012.1"
                     /translation="MKNKIKILREKLGLTQEQLGRLVGTSRQAINAIETGKNEPSIWL
                     AYDISRIFNEPIESVFLFEESERKSRAQISRGEYYGYKKDKNI"
     gene            33261..33716
                     /gene="def"
                     /locus_tag="KNP36_001125"
     CDS             33261..33716
                     /gene="def"
                     /locus_tag="KNP36_001125"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HBF0873013.1"
                     /translation="MAIRKIRTFDDEILRKKSKYVENVDNKIREILNDMAETMYNTPN
                     GGGLAACQVGVLKRLVVIDLGEGLIKLVNPEIIKQEGEQIVVEGCLSFPEVWGKLKRP
                     KKVTVQALNEYGEKIEIKGSGFMAKCLCHEIDHLNGIVFTDKIIEHVKL"
     gene            33768..34229
                     /locus_tag="KNP36_001126"
     CDS             33768..34229
                     /locus_tag="KNP36_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine dimer DNA glycosylase/endonuclease V"
                     /protein_id="HBF0873014.1"
                     /translation="MRLWHKDLIDVLPKNQLVSQWRELLAIKGSIDKKGTPNHLLVNK
                     VLNYSIDEFKFYTKIVHDEMLKRNYKPNELKYTSILKWKNRNFANDISNEHSLNLENL
                     YDDWHNKMYLKQCLYNLEEKATCGGIPINEWNILLCKYSKDYELWSGNIMF"
     gene            34279..35181
                     /locus_tag="KNP36_001127"
     CDS             34279..35181
                     /locus_tag="KNP36_001127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0873015.1"
                     /translation="MYNKIKYIPINCEIACNKLKRSMPYKWDLNIYRGCEHGCKYCYA
                     IYSHKYINSNNYFEEIYVKTNIVEKLERQLKSSKWKKEVINIGGVTDSYQPIEADYKI
                     MPEILNLLIKYKTPAIISTKSDLILRDYDLIDKLSRITYINVASTITTVNEDTQRLIE
                     PNGVDSMRRFKMLKEFRKTNASVGLHIMPIIPYITDDFDNINSLFRHAKECNVHYVLP
                     GTLYLRGITRGVFFDFVKKEFPELFDKLSILYSEGSLNREYKNQLYKMVNELRYKYSL
                     SSSYSKIMKEKLKNSGDVQISFFD"
     gene            35551..36363
                     /locus_tag="KNP36_001128"
     CDS             35551..36363
                     /locus_tag="KNP36_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBF0873016.1"
                     /translation="MYLERPELYKQSEINFWDDEYISEQLLKAHLDTNFEGASRNFNF
                     IEDSVNWIVTVANPVNYPKLLDLGCGPGLYAEKFAQKGYKVTGIDFSKRSINYAQNRN
                     KETNLNINYLFQSYLNMNYNEEFDLATLIYCDYGALSTENRRLLMEKIYDSLKPGGKL
                     ILDVFTINKYNNFEEIKYWEINEDGGFWSNEKYMCLQDNCKYNDYNTLEQTLVITEKD
                     ENVFYVWNHYFSKESFLLEVENIGFKSVEFFSNVKGEAYSDDSMTMGLVLQK"
     gene            37412..38173
                     /locus_tag="KNP36_001129"
     CDS             37412..38173
                     /locus_tag="KNP36_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896901.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBF0873017.1"
                     /translation="MIGIYFSGTGNSRYCVEKFLQEYDITANSYSIEDNELLQHINNH
                     ENIIFSYPVQYSNVPKILKDFIINHSTLWNGKRVFIIATMALFSGDGSGVLARILKKY
                     GAITVGGLHVKMPDSIGDEKVLKHSLEYNRKLVIKAEKKVTKAAKKLKHGSPPKEGLG
                     FLSHIVGLFGQRLYFINKTNMYTDKLKINTEECIVCGKCVNLCPMKNLVIKNCMIVAN
                     GQCTMCYRCVNNCAKKAITLLGKKVVEQSNIKKYM"
     gene            38238..39020
                     /locus_tag="KNP36_001130"
     CDS             38238..39020
                     /locus_tag="KNP36_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="HBF0873018.1"
                     /translation="MEYYIVDSFATKLFKGNPAGVCVLDRRIPLELMQKIAEENNLPE
                     TAFVVKCKGNYELRWFTPKAEIDLCGHATLAAAYVISNFIDVNVKRIDFFTQSGKLEV
                     TRNGNLYEMIFPEIMPIEIELSPQQANLIGCVPSAVYSSRDLILLLNSEQEVINYKPN
                     YAQLRKLTDWLGIIITAQGSNTDFVSRYFCPELDSEDPVTGSSHCNLIPYWSEKLGKH
                     KMVAAQLSNRGGIIQCEVLKDNTVKISGEAVLFMQGTIKIDI"
     gene            39287..39706
                     /locus_tag="KNP36_001131"
     CDS             39287..39706
                     /locus_tag="KNP36_001131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjdF family protein"
                     /protein_id="HBF0873019.1"
                     /translation="MDKISGKLTVLFEEPFWVGIFERQDGKKYEACRVVFGAEPKEVE
                     VYEFILERFFSLDFGSIKLEKNVTKDNIGYKRMQRKVKKEQEKETIGTKAQNALKLQY
                     EERKQDRKNLAKNRKEEEKERLFNLKQEKRKAKHKGH"
     gene            complement(39809..40075)
                     /locus_tag="KNP36_001132"
     CDS             complement(39809..40075)
                     /locus_tag="KNP36_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HBF0873020.1"
                     /translation="MKNFILIYFIVINSIAFFSMYIDKKRAIRNEWRIKEATLMSIAV
                     IGGSIGSIIGMYSFRHKTKHIKFTFGIPFILFLQFLLVYFYILK"
     gene            40302..41003
                     /locus_tag="KNP36_001133"
     CDS             40302..41003
                     /locus_tag="KNP36_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873021.1"
                     /translation="MKFIVEKEVFDKLENVCFGVVVAKGIDNTKEIERISNLLDISID
                     RVEDYFKDKKVKESEEIIPYREAFRSLGMNPNKFMSSIEAMTTRVAKNKKLPHINPIV
                     DLGNSISLKYLLPMGAHDMDFRNDDVYVRFSKKGDKFVPFGETDVELMEEGELIYSVG
                     DMVKTRRWIWRQGEEGKITNSSKNIFFPIDGFTDANLDKVMSAREELAKLLKEIFNCE
                     IKVGFVDKDNPEMEI"
     gene            41085..41693
                     /locus_tag="KNP36_001134"
     CDS             41085..41693
                     /locus_tag="KNP36_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBF0873022.1"
                     /translation="MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSE
                     QLKNIYLKNEEDSVDAVVIVGLHKSSKKLILIRQFRVPINGYIYELPAGLVDEGESID
                     ISVERELREETGLTLLEIKKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDE
                     EIEALLISQEDAKEILQSNHKIDTKAFLILQMFVSLGAKLFE"
     gene            42017..42481
                     /locus_tag="KNP36_001135"
     CDS             42017..42481
                     /locus_tag="KNP36_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4624 family lipoprotein"
                     /protein_id="HBF0873023.1"
                     /translation="MKKLVIILISIISMVSLTACKKSNESKYNNLNNKESGQTTIEMD
                     LDKNYDTSDPFVNARLFCVSNDIDVLDTEISFKMDGDSGIVEIKDNKTYETLWSNTWH
                     GSVDNDTFTISLSNIQKEKEYAICFTGIKINHAVVKVTFESNLVKEKEKPSK"
     gene            43118..44134
                     /gene="gap"
                     /locus_tag="KNP36_001136"
     CDS             43118..44134
                     /gene="gap"
                     /locus_tag="KNP36_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HBF0873024.1"
                     /translation="MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVAINARATTESLA
                     HLFTYDSCYGTFRGEVEAKDEDTLVVNSKEIKILRYNDPEELPWKELGVDIVIESTGL
                     FTQREKAEKHIKAGAKKVIITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCL
                     APFAKVLDEKFGIVKGLMTTVHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKA
                     VSRVLPQLEGKLNGFSLRVPTPTVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVL
                     GYCDKPLVSIDYKGDSRSSIIDALSTMVIEDNMVKVVSWYDNEWGYSSRTVDLVKYVA
                     EKLK"
     gene            44529..45698
                     /locus_tag="KNP36_001137"
     CDS             44529..45698
                     /locus_tag="KNP36_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873025.1"
                     /translation="MEKLTDRRQVKAVSMETFIFLILLVVGFGYVGSIMGAGMMFKVI
                     MSTAHALLLETVFLIMAMAVLAGALSALLSEFGVIALINKIFAVFMKPLYGLPGASIA
                     GAITTYLSDNPAIIPFAKDKTFTQYFKQYQVPALCNLGTAFGMGLILTTFMISQGTEY
                     VLPALIGNLGAIIGSVISVRIMLTFTKKFYKYSPEEDKATGTLEKKDEFREIREGNVF
                     QRALDAILEGGKMGVDMGMAIIPGVLVVCTLVMLLTFGPSTDPVTGQEVYTGAAYEGI
                     KLLPVIGDKLGFILEPLFGFTSPEAIAFPITSLGAVGAAMSLVPEFIKSGAITPNDIA
                     VFTAMGMCWSGYLSTHIGMMDALNARQLAGKAILSHTIGGLCAGAAAHFIFTLVG"
     gene            46078..50331
                     /locus_tag="KNP36_001138"
     CDS             46078..50331
                     /locus_tag="KNP36_001138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="HBF0873026.1"
                     /translation="MDELFHIGIDVGSTTVKVVVLNNSNNIVHKEYRRHYSDVKKSVK
                     EVLNGIYEKLGDINTTIIITGSGGIGISKKLGVKFVQEVISSTKSIEYFHPETDVVIE
                     LGGEDAKITYLSGGIDQRMNGICAGGTGAFIDQMASLLKTDASGLNELAKGYNVIYPI
                     ASRCGVFAKTDIQPLINDGANQTDIAMSIFNAVVVQTVSVLSCGRKIEGNVAFLGGPL
                     YFLSELREAFKRVLDLKDENIIFPENAQLYIAIGAGLLSVDEDNIQLKSLIEKLDSIK
                     NIEDGEVNLLEPLFKDKNEYEEFSRRHEKEKINYVDINSIKSNCYLGIDAGSTTTKAA
                     LIDEDGRLVYSYYNSNEGNPLKTTIKVINEVYDILPKNIKILSSTVTGYGEGLIKKAL
                     KIDNGEIETIAHYKAAKFFNKDVDFILDIGGQDMKCLKIKDGVIDNIILNEACSSGCG
                     SFLETFASSLSMTIEEFAHEGIYSQNPVDLGSRCTVFMNSRVKQAQKEGASVGDISAG
                     LSYSVIKNALFKVIKIRDLNEIGNNIVVQGGTFYNDLVLRSFEKLIGKNVIRPNISGI
                     MGAFGSALIAKEKYESGYKTSLLSKEELNNIKLEASVTRCKGCSNHCLLTINKFSDNE
                     IFISGNRCEKGEAIYGDKKIGLEKKKPINLFKYKYNRIFRYKPLEKEEAKNGEIGIPR
                     VLNMYEDYPFWFTFFNAMGFRVVLSDRSSKQLYETGITSIASETVCYPGKLVHGHIEN
                     LIAKGIKNIFYPSVTNENKEDSNADNYYNCPVVISYSEVIKNNVENIRNKNINYINPF
                     ISLNDKEKLKKRLYDELSRHFSDIKITKEEVNHAVDKATDEQNLFKMEIQAAGERALK
                     EIKERNMKGIVLCGRPYHIDPEINHGMPELINSLDMAVLTEDSICHLANVQRPLRVVD
                     QWVYHSRLYKAASFVRDKNYLELVQLNSFGCGLDAVTTDQVQEILNEKSKIYTIIKID
                     EGNNLGAAKIRMRSLKAAMFERESKNIDVKNIKVNRIQYAKNNQITNKHTILAPQMSP
                     IHFQFLEKAVNLSGYNIEILKDTDSSVIEEGLRYVNNDACYPAIIVVGQLITALKSGK
                     YDLNNTSVTITQTGGGCRATNYIGFLRKAIYDAGFKDVPVIALSVNGIEDSGIMDNIS
                     LKLINRLFMSVVYGDLLMKVLYRVRPYEKVTGSANALYEKWVDICKSSLVKAKISVFT
                     RNIKDIVKEFDNLEILDIKKPKVGLVGEILVKFHPIANNNLVDILEREGAEAVVPDLT
                     NFFLSCAFNTIYKHTHLEGSRKSRMIGEAFIYITGIYQRVYKKALDKSERFYAPANIK
                     NVAKSTEPVVSLGNQTGEGWLLTGEMVELLNEGVENIICMQPFGCLPNHIIGKGSIKE
                     LKRLYKNANIIPIDYDPSASEVNQLNRIKLMLSKAFKNI"
     gene            50480..50974
                     /locus_tag="KNP36_001139"
     CDS             50480..50974
                     /locus_tag="KNP36_001139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HBF0873027.1"
                     /translation="MSLVYDVYKSKLGNLYILSEDGFIVSIYIGDEKFNNLKNECIKK
                     GIDIKRSKEDLKEAISQIDDYFNGKRKVFNLNIRIEGTEFQKSVYREMLKIPYGETLC
                     YSDIARNINNPKSVRAIGQASKSNKIPIIIPCHRVVGKKDIGGYMGNHSDLKEILLNL
                     ERQS"
     gene            51090..51467
                     /locus_tag="KNP36_001140"
     CDS             51090..51467
                     /locus_tag="KNP36_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="monooxygenase"
                     /protein_id="HBF0873028.1"
                     /translation="MCDKVIASKYHEKGFNCAESVIKAYNEEFNTDIPVCLGSGLGSG
                     CGVASLCGAVNASNIIIGYVKGRNHEDESTKAKVYAKDLTTTVRKEYGSELCIDLKKD
                     LVACREIMDFAYDSLKETLKKEL"
     gene            51673..52113
                     /locus_tag="KNP36_001141"
     CDS             51673..52113
                     /locus_tag="KNP36_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SufBD protein"
                     /protein_id="HBF0873029.1"
                     /translation="MKNLNLLINKLYSKNHNEAYKTFLFLENESLKSNITYCFFDSFL
                     EMIDNENSYIRTRGLLLISANAQWDIDNKIEINIDSILSHIVDKKPSVSRMFIKSIPN
                     ITKYKENLINRIKMELSNADISIYNNNMKPLVEKDINDTLSNIS"
BASE COUNT        20893 a         5437 c         8577 g        17333 t
ORIGIN      
        1 taatatcaac actacattaa aacacaacct aaatttgaaa aacaaatagt ttagaaatat
       61 gtactttttt atctattata ttcttttaaa tcgaattttt tcatctgaac ataaagtctc
      121 aaatctatat gcgtctgtca tatcataaaa accaaaaaat ataaagccat cacgagaagt
      181 aaattcatat tgtatatttt caattttcaa catgttttct acttcgctta ttttttcgct
      241 atatataatt tctaccatat aatttatcat tgtagaatcc ctcctattaa tatgaaaata
      301 tccaaatata taataacata tttagatgat ataatagtat ccaaataaaa aataatatta
      361 ttacattatt gaatgaagaa ttaaaatgaa gataaataaa acaaatattg gttataattg
      421 attaaaaaat agttatgtat acttgtgact ttatttatgg gcagttcaag ttttatgaaa
      481 gaagtcatat atatatggaa tattctaggc agaaactgtt taataataag agaatactat
      541 aaaaatttga gtattacata aaaaataaga agccataaat gatataagca ttatctatag
      601 cttcttactt ctcattgatt aagattatat ataaaaataa tcactatatt ttttgtttaa
      661 gttttagtac ttgttttact atatttgttg agtggtcaga aattctttct agattagtaa
      721 gtaagtcaag ataaagtaca ccagcatcaa ttgtacaact tccattattt agtctaatca
      781 tatgtgaatt tctaaaagtt ttttctaaat aatttacttc attttcaact tctaaaactt
      841 tatttgctaa ctcaaaatct ttaacatcta aaactattaa ggcatcctta aaattagtaa
      901 ttgtcttatt gtatatttcg tatatttctc ttatcgcact atcagaaaaa ctaatgttca
      961 tttccttaac actcatggcc aattcagcta tattttctgc atggtcagag actctttcaa
     1021 tgtcatttac agtattaaaa agcaaatctg ttctaaagcg ttcatcatct ctaagaggtt
     1081 ctttagaaag ttttaacaaa tagttcaata tatctttctg taacttattg acaacttttt
     1141 ctgactcaaa agctttatta atatcttcat tgctcttatt taaaaatcct gcaattgaat
     1201 gttccaaaga gtttgtagct ttatgaccca ttcttacaac ttcttgtaca gtattaccaa
     1261 gtgctataga tggagtgcta aacatccttt catctaagta cttagtatta tttactattt
     1321 ctgattcagt ttctttaata ggtataagtc tatttgctaa tttaactatg tatttagaaa
     1381 atggtaataa tattataaca tttgtaagat taaataaagt atgtgcattt gctatttgtc
     1441 tagctgtatc agttgggtca aaatgagtaa ctatggctga tataggttta tttaaaacaa
     1501 gcataaatat tattgtacca attacattaa aacttaaatg cattacagct gcacgtcgag
     1561 catttctact tgcaccaaca cttgataaaa gtgaagtaac acaagtacct atattatctc
     1621 cataaagaat aggtaaagca gatgatagag gaagtattcc ttgagaagct agtgctatta
     1681 acatacccat agatgcactt gaactttgaa caataccagt tatggcaaat cctgccaata
     1741 tacctaatac aggattttta ctaaaatata aaagtgcatc agtgaatgct ttatattcag
     1801 caagtggagc tactgcatct ttcataaact ccattcctgt aaataatata ccgaaaccta
     1861 taagtatctc agataaatgc tttgtttttt gatttgatgt aaataaatag aataaaatac
     1921 ctatacctaa agcaattggt gcaattcctt caagattaaa tgaaactaat tgagcagtaa
     1981 ctgtagtacc tatatttgcc cccattatta caccaatagc ttgacttaga ttcattatac
     2041 ctgcatttac aaatcctaca accataacag tagtagcact tgaactttgt ataatacctg
     2101 taacgactgt acctaccagt acacccataa caacattact tgttaagagt tcaataattt
     2161 tttttaattt gtctcctgct gatttttgta aaccttctcc cattaaactc attccgtaaa
     2221 gaaaaagtcc aagtccaccg ataaggctaa ttactatatt cacgatattt cctcccttaa
     2281 gaaattaata atttttttat ctgaattata aactttatta actaaaattt attgtttcca
     2341 taatatagaa taacaaattt tgtcaataaa aatattaatg ttttgttaag tatacgttaa
     2401 gagaatgtta aatttttaag ttgttgttaa ttttagaaaa tttatgatat atagcaattt
     2461 aaatacttga acttagattt ttagtatttt atgtacaatc aatttaacaa agaattaact
     2521 ataattgtaa aaaatatgta aaaaaataac atccttttag aatgatattt tttagttata
     2581 aatattttta tattcaattg gtgtaaagtt attaaacttt ttaaaaatta tactatagta
     2641 attttgacta ttgaatccaa ttagtacagc aacgtctaaa atagacaagt ctttttttaa
     2701 tatatacttt ttgctttttt caactctaac tttacttaaa aaattagtaa aagtatatcc
     2761 actttttttc ttaaataaag aaaaaaacaa cttttattaa gttgtaattc attacatata
     2821 ttacttactg ttatatcttc tgagtaattt ttgtgaatat aatctatagt tttctttaag
     2881 ttttctttac ataaaactaa gagttggtct atgtttcatt ttatcaaggc atatttatta
     2941 aaaaatcaat ctctatttgt taaaataatt tatgaatgat gttagaaact gtaatatatt
     3001 ggatataata taataaacag ataaactctg tattaagagg atatatagtt tatcttaatt
     3061 ataggggaag tgaggatata ttatggaaag attaatggaa ctcatagaaa gaaaattttt
     3121 aaaggatgta gaacttttag aattagaaga catagaaaat gtaatagaat gcaaaatgac
     3181 acagccatat aatgctcatt ataatgaata tttagtaaaa gtaaaaaatg gagatgaagt
     3241 agaagaatat tttgtgtatt taaaacatag ataaacataa aagaggttta tatttatttg
     3301 tatgattata aaataaatac aagcctcttt ttttgataaa tataaaatta taaaattttt
     3361 atttatttaa ttttttcaac aacattagtc aatattgaat ctaaatcatc actaatttct
     3421 gtaactccat tatgagtaat atctataatt tctttagtca taggaagttc tcctaaaagc
     3481 tctaagtcta aatcatctaa aaacttttca gtagattctc cttcaaataa cttgattttt
     3541 ttagaacaat caggacattg gatataactc atattttcaa taactccaag gacatttatg
     3601 ttcatttttt tagccatatt aacagctttt gatacaatca tagataccaa atcttgaggt
     3661 actgaaacca taactattcc acttatagga atagattgca taactgttaa ggcaacatct
     3721 ccagtaccag gaggcatatc tattaataaa tagtctaatt cttcccaaag aacatcagta
     3781 taaaattgct ttacaacccc tccaagtaaa ggtcctctcc aaacaacagg ttcattttca
     3841 tcatctatca taaggtttat agacattact tttatgttat ttgagttttc tacagggtaa
     3901 atataagagc catcagaata agcttttaca ttttttacac ccataagtct aggaatactt
     3961 ggtccagtta tatctgagtc taatatacca accttatatc ccattttgtt tagcttatta
     4021 gcaagtaaag cagttacagt tgattttcca actccaccct tcccactcat aacaccaatt
     4081 atttttccaa atttattgtt agggttattt tcaatagaac aatttgattg actattacaa
     4141 tttccctttg atggacatga attacaatct gccatatcta ttacctccaa actttaatat
     4201 ttattagatt atttgtaacc tacatatact attttagtac aattgaacca taaagtcatt
     4261 atttaaaagc aacttagaag attttctatt gatttattca tagactatag caaaaagaat
     4321 acaataaaaa aattataaca ttcttgaaaa agtgattatt tcaatttagt tatagaactt
     4381 agtcatataa atatatagaa aatattttaa tatgttatac ataacgggtt attttataag
     4441 tttaactata aattaggttt atattttata aaaatttgct aaaaaaaaca attaaaaatt
     4501 gtaaagaaaa aagatataat tagaactgta gtaataaatg ttttattata gataatagag
     4561 ttttaagtat cttaaataat atttggagga atatgaatgg aattaagacc aagaagtgca
     4621 aaattagaag aatttgataa agtaatagaa ttaataaact atgtatttag aatatcaaga
     4681 aatcataaac caactatgat ggaagaattt cctcttttac taagtaaaaa taatatagaa
     4741 aatatgatta taatatcaga agatgataaa gtgatttctg atgtaaacta tctaattcag
     4801 gatgtatcta ttcaaggaaa cagattgaag gttgcagcta taggtggagt atgtactcat
     4861 ccagattatg aaaagagagg ctattcatct aagatattgg ataaagtaga agaaaaaatg
     4921 ttttatgatg gtgtagatat tgtaattata tcaggaacaa gaagtctata cagtagaaga
     4981 aattgtagtt tggtaaagag tttttataaa tatacaataa aacctgaaga tgtaaaaata
     5041 gcatatgaaa tagttgaatt tgatgaaact aattttgaaa aagataatga tttagataaa
     5101 atgattgaac tatataatca aaatagtact agatttataa gaacgagaga tgagtttcaa
     5161 aaactattgc atgcagcaac tattgcctgg ggaccaattg gttacaagaa ggtatttata
     5221 aaggaaaata ataatataat aggatatttg ataataagaa caataaaaaa agaagattct
     5281 actgtaggag aagttgctga aatagggtta aactctgtaa atgttgaaaa tatattgaaa
     5341 tatgttgcaa ataaatttgg attagaatat ttaaattata aagtacatgt gaaaaatctt
     5401 aaagaccagt tgaaatgtaa tgggacaaaa tctttggatt atcaacaagg aactatgaaa
     5461 ataataaatt ttactaagtt gtgtgatagt ttaagaagtt attttagtca atatgtagat
     5521 tttgaattac taaaatacat ggaatttaaa caagttgaaa ataaatatat tattaaatac
     5581 aaagaagaag aacttgtaat agaaaatttg gataagctta ataaactgtt ttttgaaaaa
     5641 aatgaggaac agtacaatga atttaaacat ctaaaaaata tatatgaatt tgctacaaag
     5701 gcatttcctg tagattttcc atggactgca aatttaaatt atcaatagtt ttagatgata
     5761 ttaaataaaa ttgattgata cctagagtta gtccttgtta aataagagaa attattggat
     5821 attgaaaaag caattttgta agtaattaga aaggatgagt attatatgga catacttgat
     5881 gatatagcag aatgtatatt aaatatgggt gtagataata tagagaattt agtaaaaatt
     5941 gctatagata aaaatattga tgtggaagat atttatgaat atggtttaaa caaaggtatg
     6001 ataggagctt tagataagtt tgagaataag gaatactatc tttcagaagt tatagtatgc
     6061 acagatgcat taaataaagg tattaatctt ttgaagggaa ctggaaaagt aaagaaaaaa
     6121 tcaaagggag taattctgat gtctgtagta gaaggagata ctcatgagat aggaaaaaat
     6181 attgtaaaag taatggtaga agccactgga tataaggtta ttgacttagg tgtaaataga
     6241 aaaagtgaag atataataga agaagctata aaaaacaatg tagatataat aggcttatct
     6301 tcaatgatga caactacaat ggaaaatatg aaatcggtta tagacgaact taatatgatt
     6361 gagatagata aaagaccaaa agtaataatt ggtggaggac ctgtaagtat ggagtttgca
     6421 gaagaaatag gagcagatgg atacagttca aatgctccaa aagcagttaa attaataaat
     6481 aaacttatag gaggtgaagt ttaaatgttt tcagatatga ctttacttca gtatataaat
     6541 agtgaagata gaggtttttt tctgcctgat atgggtacaa atggattgtt cttaataaat
     6601 aaaaaggcat atgaagtata tgatagtgta gatttgcaat tagaattagc aaagactatg
     6661 gacaagtatt ttgaatcaga ttttatatac tcattctgtg atgggattac attttgtgaa
     6721 actctgggtt tagagacatt aagaccagat tatgattttc caagtgtatt gacacatact
     6781 ataactgaca gagataaatt aagaaaatta gatgttccag acccttatac gagtggacgt
     6841 atgccactca atatagagag cttatcagtt atatcaaaaa gtattaaaaa accactatat
     6901 gaatcgatac aaggtccatt tacacttgca ggtcaattag ctggagctac tcaactttta
     6961 agatgtataa taactgataa aaaatttgta gaagaattat tggaatttac aactgaattg
     7021 gtaagaagat atgctgtagc tgcaaataaa gcaggagcaa aatatatttc aatagcagag
     7081 ccaacatcag taaccctaag taaagataga tttgatgaat ttatagtaaa aaatttaaat
     7141 aaaatctaca atgaacttga ttgttggaaa ggtatgcata tatgtggaga caccagagaa
     7201 ttattagata atatgctaag ttgtaatata gatgcagtaa gtttagacca aattttagac
     7261 tatgaagaaa ttgctccaat gattcctaga gatatagttt tgattggtaa tttagaccca
     7321 ataaaacttc ttggacgttc taagccagat aagattagaa gagagacgct aaaattgtta
     7381 aagaagatga gaagatatga taacttttta tgtgattttg gctgtaactg cttaaatacc
     7441 actccagtag aaaatttaca agcagctata aaggcaggaa gaattagtta taaagaatta
     7501 gataggattg atattgatga attataatag taataaaaat aaatatcttt taaaggatat
     7561 aaatttagat gatattttta tagataagaa tattgtgcta aagtttttgg ggtatggaaa
     7621 tagaaaagct ccagatacaa ttagtaaaat cgttgaaaga gaaataagaa atataaatga
     7681 tattttagat atcaagatat atataagtga agttgatatt aataaaacac ctaaagaatg
     7741 taaaaaagca tttgctgtac tatatacaat aggggataaa attgatatta agatgaatga
     7801 ctatatggaa aattgcaata tgatggcagg gctagcattg gataaaatag gtatagtatg
     7861 tttagattat attaatgaga aaataaaaat gtatttaaaa ggaaagtatg atagtctcaa
     7921 aatatcgcat gaaatatatc caggagataa agattttgaa gtagagagac aaaaggatat
     7981 ttataactat gtaaaaaata aatataatag tatagaaata gaaattaatg attatcatca
     8041 actatccccc ataaaaagtg ttgcaatgct tattttaatg ggggatgaag aaaatttaga
     8101 atcaagatgt agtaagtgtc ctagaaaatg cttttagtta attttcaaga ctaagatttg
     8161 ttttgtgtat aaattgcaat aatttttttg gtcattttat gtataaacta aaaaaattat
     8221 tgcaaagtaa tattctattt aatttgaaca gacttacaaa ctatagtagt ttctttaatt
     8281 caataagtgt atttatttca taagttggta tatgattagt ataatttata ctgttattgg
     8341 aatttaacca acaagtatct attcctgaat ttattccacc taagacatca gaggttaagc
     8401 tatccccaat tattaaggca gaagatttat catgacaatt aaactttttg agagcgtatt
     8461 taaatatttc aggatttggt tttgatattt tcaactcttc agatacaacc attccatcaa
     8521 tatatccttt tatttttgaa ttttcaagtc ttttattttg aactgcagaa attccatttg
     8581 ttattataac aatagtatac ttttttttaa gatattgtaa tatatcgatt gcacctggaa
     8641 ttaaaaatgt acattcacct aaaaaattta agtacatttt gctaagagtt tcagaatcaa
     8701 catccaaaga tattttattt gcaaaaagtt caaatctaag taatttaagt tcattcaaag
     8761 ttataatatt tttttcaagg tcgagccaaa gcttatcact tatatttcta tatgactcta
     8821 tataattctc aaaattaaat tctaaatcaa actcagatag aagtttttta aaagcatgtg
     8881 attcactttt cttaaaatca aataaagtat catctgcatc aaaaaatata aatttatatg
     8941 tcttcatggt ttttactcct ttacaagatg actgcaaaaa ttactttact ttcactattt
     9001 gagtcatttt gccatttatg ttttgttcct aaaggaactt ttacactatc tcctttggac
     9061 aaagtaaatt catcatcatc cataaaaagt ttaacttctc cctccaaaac atatgcaatt
     9121 tcatctccat tatgagtaat cctatcaaca caagaagaag tgtttggagc taaatccata
     9181 attgcaaatt ctaaattacc actagagtct ggaattaaaa tctcatatat aacttctttg
     9241 cttccaggta aaataacttt ttttctatta tcatgtctta ctatcaagtt ttttttatct
     9301 acttcagata caaaaaatgt aaataaagga acatttagag aagaggctat agattttaat
     9361 gaatttacag atggattagc aagacctcgt tctatttggc tcaataatga tggtgtaaca
     9421 tcagctagtt ttgctaaatc tcgaatactt aagttttgtt tttttcgaac ttcagctatt
     9481 ttttccccta aatttaaatc attcatataa atatcctctc tttttaattt aaaaaatatt
     9541 aacttaaaat aatcaagtaa aatgattatg tagtatgaaa ttattataac atatagaatt
     9601 aggttttgaa aaaactatgt tcaatataat taaataaatt aaaatataat tgacaaagtg
     9661 gatacagaat acttaaaata tatttaaata aaattaagca aaagatagtt aatttatgat
     9721 aggaggggat attatgcaaa taacgacttt tggagctata tttggtttat taatagcaat
     9781 tattttaatt ataaaaaaat ttcaagctgt atatagttta atgttaggag catttattgg
     9841 aggattagtt ggaggagcaa atataacaca aactgtagat tttatggcaa atggagctat
     9901 gaatatatca ccatcaattc ttagagcttt ggcatcaggt gtattagctg gaagtttaat
     9961 aaaaacaggg gcagtagata aaatatcaga acagattgta aaaatatttg gtgaaaagag
    10021 ggctttattt tcgattgcca tttcaactat ggtacttgct ggagtaggtg taaatttgga
    10081 tgtatctata ataactgtag cacctatagg attatatata ggtagaaaat taaattattc
    10141 taaattgtca atactattag ctatgttggg agggggtaaa gcaggtaata taatatcacc
    10201 aaatccaaat actatagcag tagcagataa tttttctgtc aatctctcta gtgttatgat
    10261 ggcaaatata attccagcaa ttattggagt tgttattaca gttattttag caagtatatt
    10321 aataaataaa ggaaataaag tacaatcata tgaaatttta gagcaaagag aagatttacc
    10381 aagtttattt aaatcattat gtggtccaat tatagctata tttctattgt ttttaggaaa
    10441 tgtatctcct atagttatag acccaatgat agcccttcca ataggaggaa tcgtaactct
    10501 aattgtcaca ggaaacttga acaattcaag agaatattta acttttggat tatctaagat
    10561 gcaaggggta tgcatattat tacttggaac agggactatc gcaggaatta tacagatgtc
    10621 tgaattacaa cagagtacaa taggtgcttt acaattttta aatatgccac aatttttatt
    10681 ggcaccagtt tcgggtatac ttatgtcatt agcaacagca tcatcaacag ctggtgctac
    10741 tatagcatca tctacttttc atgatgctat aataaatggt gggctatcac cgatttcagg
    10801 tgcatcaata gtaaatgctg ggtctagtgt attcgagcaa ttaccacatg gctcactatt
    10861 tcatactagt gcaggtagta taaacatgga tataggtgaa agatttaagt taattccata
    10921 tgaagcattg ataggaatag taatgactat aatttcaaca tctattcaat tagttttata
    10981 ataaatataa atatttaatg aaaaaagtag gattttgtta ttaaatattg aacttattat
    11041 agtaaaaaag aagattggag ttttaaagtg aataaaaaaa agattgttat tatagggatt
    11101 atttattcat ttttagtagt attttcactt acaaatatgt atgtaaatat ggagtataat
    11161 ctaaatgtat ttgaatatat taagaagtca cttccattta cagaagaaga aaaaaagtgg
    11221 ttagaaaaac acaagaattt gatttacagc tctgaccaaa gttcacctcc tttgagatat
    11281 aaaggtaagg aagatggaca gtataaggga attattgttg atttaataaa ttctctgtca
    11341 attcaaattg gtagagattt ttattttaaa ccaaataatt ggtggaaaga atctttcgta
    11401 aattcaatag atgatagtat aaagtttttt gacttgattc catcaaaaga aagggcaaat
    11461 aaatttatat ttactgaccc aatatacact ttgagtgcaa atatattgaa agataaaaag
    11521 tcccaagata taaatagtta catggattta aaggggaaaa cagtagcaat tccagaaggt
    11581 gattattcta taaatttttt aaagcaaaaa attcaagata taaacatttt attgactcca
    11641 gatataaaga ctggagtcaa ccatttaatg tctggaaaag tagacgcagt tgttggtgat
    11701 gaaccagtat tgcgatacta tataaataat tatggacttt caaataaata cagtgtttta
    11761 agtaatccta tatatactaa aaaagcagtt cttgctgtac ctaaacaata tgaagagctg
    11821 gttagtattt taaataaagg catttttaaa cttcagaaaa atggagtgta taaagattta
    11881 aagaaaaaat ggtattctac gtataatgaa gttgatgata tattgtatga gcgaggaatt
    11941 gtgcctagta tttatctttt tataggtata attttaatat caatttatgt tttttatagc
    12001 tatacatatt tgttaaagat agaaatcaaa aggaaaacag aacaggtaat agaaaataaa
    12061 aaaactttag aggcaacttt taatagtatt acagatataa taatgcttgt agatgaaaat
    12121 aacaatatag tagaatcgaa caaagtacta tatgacttta tgggtgaaat gagttataag
    12181 atagcagatt tgattagcat gataaaaggt gttattgaaa ataccttctc tgaaaatact
    12241 aataaaacta gtgaaataga aatacacaat aaaattttaa agataaacac ttttcctgta
    12301 gagtataaaa aaaataatac tgagtatata gtagttctta ttaaagatat aactaatgat
    12361 aaaatagtag aggcgaaatt acttagagaa aacaaaatga tatctatagg gcaattagct
    12421 tctggggtag cacatgagat aagaaatcct ttgggtataa taagaaataa ttgctatctc
    12481 ttaaaagata acgttacaat ggaagaagta aatgattgtg ttaaatcaat agaaagtaat
    12541 gtagataggg caagtaatat aataaccaac ttgttaaatt tcgcaagaat atcagatgat
    12601 aatttagaac atataaatat aaaaaatttt attgaaaata tagtgaaact tcaatataaa
    12661 atgttacagt taaagaatgt tgaaataaaa attgactgtg aacataattt aatatgctat
    12721 ataaatggag aatcgttaaa acatgtattt ataaatttaa tttctaattc aatagatgca
    12781 atacatcaag atggaaaaat tattatatac tgttatgaaa aaaatcattg tttatttata
    12841 gattttaaag ataatggtga aggaataaaa gaagatgtcc taaaggacat atttaatccc
    12901 ttctatacaa caaaaccaat tggtgaggga actggtttag gtttatatat tacttataat
    12961 gagattaaaa agaataatgg agatataagt gttgaaagta aattgggggt tggaacttgt
    13021 tttcatataa aaattccatt aaataaagag gtgactatat aatgaaaata ctattagttg
    13081 atgatgagct agaatatgga gtggtaatga aaaaaattct acaaaagaag ggctatcttg
    13141 tagatatagc actaagtggt gaagaagcta taaatataat taaaaaagat aaaaattatg
    13201 atttggtttt atctgatgtt atgatgaaaa atatggatgg agtacagcta ttagatagaa
    13261 ttaaatctat taatagagat atagaggtta tattagttac aggatatgga agtattgaaa
    13321 atgcagttga tgctatgaaa agaggagctt tatcttattt tataaaaagt aatcccattg
    13381 aaaatttatt agaagaagtt gaaaaggtaa aggcaagtaa aatatctgtt tctgtacaaa
    13441 aaaataattt tgaatttact ttggaatcta aaaatagaga ttttaataat atcataaaaa
    13501 tagcaaaaaa agctgcttgt aaagatgtta atatattaat cttgggggaa tctggtgtag
    13561 gaaaagatat attagctaga tatatacata gcataagtcc aagaaagaat gagatatttg
    13621 tacctgtaaa ttgttgttct ttttcagaaa atctattgga gtctgagctg tttggtcatg
    13681 aaaaaggttc ttttacagga gcagtagata gtagaaaagg tagatttgaa ctttcgaata
    13741 aaggaactct atttttggat gaaataggag atatacctct aaatgttcag gtaaaacttt
    13801 tgaggacact tgaggacaaa tctatagaga ggataggaag taataaatct attaaagttg
    13861 actttaggtt aatttgtgct atgaataaag aaccaaaagt ggaaatatca aatggaaata
    13921 taagagaaga ttttttttat agaataagta caataacaat aactatacca ccactaagaa
    13981 agagaagaga agacttaact actcttatag aatttttctt aaataagtac caaattgaac
    14041 atgataaaaa gatacactcg attgataagg aagtaaagga ttttttatta aattacaatt
    14101 atccaggaaa tataagagaa ttaaaaaata taataaatag acttgtagtt ttaagtgaag
    14161 aaggtaattt atcaaaagac aatttaaatt taatatcaaa taatgtatac atagatgata
    14221 aaataagtat tagaccttta agagaaataa gaaaagagtt tgaatgtgag tatattgaaa
    14281 aagttttatc tttgtgtgga aataatattt caaatacagc taaaaaattg gagattagta
    14341 gaagacagtt aaccaataaa atatcagagt ataatattaa gtgagaaaaa aacttctcat
    14401 taagtgagaa aaaaatttct caaactgtat taaaagataa acagaaaaaa tctgtttatc
    14461 tttttttatt ataattttaa aaattaatat ttacaataat tattgctaaa ttcaatattg
    14521 gtgtaaatta aaaatgaaaa tttctatgac attaatacat agaatatata ttttaaataa
    14581 ttggcataga aaatgcttta tatattaata aacgtaataa atacttttaa ttgcgattaa
    14641 atatattaag ggggattttc atatgaagct agagctaggg aatatattta taaaaaatgt
    14701 tgaatttgga gaaaagacag aagtaaaaga tggagtacta tatattagta gcgaagaaat
    14761 agaaaagata gtattagaag atgaaaggat tgtaagtgta aatgttgaac ttgcaagacc
    14821 tggcgaatca ataagaatag ctccagttaa agatgtaata gagcctagag ttaaaattgg
    14881 agatgaaagc aaaatatttc ctggaattat aaataaagtg aagactgtag gaagtggaag
    14941 aacccatgta cttttaggag cttgtgttgt aacttgtgga aatatagttg gatttcaaga
    15001 aggcgtaatt gatatgagtg gtcctactgc taaatataca cctttttcaa aaacaaataa
    15061 tatatgtatt gttataaaag caaaggatgg tatagatact catgattatg aagaagcagc
    15121 tagaattgca ggattaaaaa taggtgcata tgtaggtgag gcaggaagag aagttgagcc
    15181 agatgaagtc attgtatatg agacaaagcc attattaaaa caagtaaaag aatatccaga
    15241 cctgccaaca gtagcatatg ttcacatgtt acaatcacaa ggacttttac atgacactta
    15301 ttactatggg gtggatgcta aacagatagt gcctacattt atgtatccaa ctgaaataat
    15361 ggatggagct ataatatctg gaaactgtgt agcaccatgt gataaggtta caacattcca
    15421 tcatttaaat aatccagtta tacatgactt atataaaaga catggaaaag atttaaactt
    15481 tataggagtt attttgacta atgagaacgt attcttagtc gataaagaga gaagctctga
    15541 tatggtagct aaattaatag aatttttagg agttgatgga gttctagtga cagaagaagg
    15601 ttatgggaat ccagatactg acctaatgat gaattgtaga aaatgtagtg aagttggagc
    15661 aaatgtagtt ttgataacgg atgaatttcc tggaaaagat ggcaagagtc aatctatagc
    15721 agacgctact aaggaagcag atgcagttgt ttcttgtggt caaggaaatc tagtggttca
    15781 tttcccagca atggaaaaaa ttataggaac tttagattat gttgaaatga tgataggtgg
    15841 gtataaagga tgcttaaatg aagacggaag catggatgca gagctacaaa ttataatagc
    15901 atcaactata gcaaatggct ataatcattt gacagcaaga tattattaaa taagtatttg
    15961 aatataaagt tctgttgatg taatcattgg tctaactgat gtaataacta taaagtgatt
    16021 tggaggatta agagatgagt aaaatcagag tggttcatta tataaacaat ttctttgctg
    16081 gtataggtgg agaggaaaaa gcagatattc cgccagaaaa aagggctggt gtagtaggac
    16141 ctggaatagc atttcagagt caatttaatg atgatgcaga gataatctca actgtaattt
    16201 gcggagatac gtattttggt gaaaatattg agagtgcaac tcaagaactt ttaaaaatga
    16261 taaaagaaga aagccctgat ttatttattg caggcccagc atttaatgca ggtagatatg
    16321 gagtagcttg tgggactatt tgtaaggcag ttgaagaaga gttaaatatt cctgtaatta
    16381 caggcatgta taaagaaaat ccaggtgtag atatgtttaa attagatttg catatagtgt
    16441 ctacaggaaa ttcagcagca agtcttagaa aggtagttcc aataatgacg aaactaggtc
    16501 ttaaattggt tagaggtgag gaaataggac ctcctgaaga ggaaggatat ataatgagag
    16561 gaataagaaa aaatttcttc catgaactta gagggtctga aagagcaatt gatatgttgg
    16621 ttaaaaagat gaaaggggaa agctttgaaa ctgagtatcc aatgcctgaa tttgatagag
    16681 ttacacctat gaaacctgtt aaagatttat ctaagataaa acttgcccta gtaacttctg
    16741 gagggatagt tccaattgat aatccagaca aaattgaatc ttcaagtgct actaaatatg
    16801 gaatttacga tttaacagat atggattcta tgtcaaataa agaatttaca actatacatg
    16861 gggggtatga cagagcatat gtccttgaaa atccaaattt agttgtacca ctagatgtag
    16921 ttagagagct tgaaaaagaa ggtgtaattg gagaattagt agattatttt ataactacta
    16981 caggaacagg aacgagtgtt ggcaattcta agagatttgg agaagagttt tctaagaaat
    17041 tgttagaaga tgatgtagat gctgtaattt taacttctac atgaggtact tgtactcgtt
    17101 gtggagcaac gatggtaaaa gagattgaga gagctggtat agcagttgtt catatatgta
    17161 cagtagtacc aatatcactt acaataggag ctaatagaat tgttccagca gtagggatac
    17221 catatccact tggaaatcct atgttaggag aagaggaaag taaaaaaatt agaaagaata
    17281 tagttttaaa agctttaaat gcactaacag aagatataga agaacaaaca gtatttgaat
    17341 aataaaaata caacacaaca ctgaaataaa aaaagatatc aaaaaataat tttttaaaat
    17401 tattttacga tatctttttt tattaggtaa attcgaaatt tgcatttttt taaattaaat
    17461 ttataaaagt gataaattag tttattataa tattgataca caaattcaaa ttagatatac
    17521 tatgaaaagc gagattatta cattttggaa caaatattca acatattaga tcatattaat
    17581 tgaacagaaa aaattaactt tatataataa ttagaataat gataagaaag aaggtgtata
    17641 tattgatttc aattgccatt tgtgatgatg aatcctatat gctaaatcat ttaaaggaaa
    17701 atatagaatt atacatgaag cagaagaatt tattatataa tatagagctt tttaataaag
    17761 tagaagattt actatgcaat catgaaaagt ttaatattgt atttttagat atacagatgg
    17821 aagagattaa cggaatgcag gcagctagaa aattaaggtc atatggtaat gagtgcttta
    17881 taattttcgt tacagtttta aatgaatttg tatttgatgc ttttgaagta gatgctataa
    17941 attatctgat aaaacctcta tctaatgaga aactatataa aactttggat aaaatagtta
    18001 caaaacttga tgataatgaa agtaattata tcacaataca aaaaggttat tcatattgga
    18061 aattaaaact tgctgatatt ttatattgtg aagttataaa aagaaagatt tatgttcatt
    18121 taaagaaaga gactgtagat tattatgaga ctattgaaaa tttagagaga agtttaccaa
    18181 caaatttttt taggtgtcat cgtagttata taatcaattt acaatatgta tatggatatg
    18241 aaaatggtaa tgcagttatg gaaagtggag atagaatacc tgtttctaga ctacgtcaac
    18301 aaatattttc aaaagttatg cttgagttca tgaaaaatag gaggatataa gatgattaat
    18361 ttattttctt ccgatttatt tttaaagtac agttttttct tctcttttat tgtatataga
    18421 attttaatgg taatagtgca atactatttt ctaatcaatt ttacaaattt taattcaaaa
    18481 ttttggtgtt ttattttata ttcgataatt tcaatttttt taatcattat aaatacatat
    18541 tttaatttat ataatttatt ttcttcacag attctatttt ttcttatgac ttttttattt
    18601 gtaaagtaca taataaaaca atctactgtt ttatctatag tatcaacttt gttagtatat
    18661 ttaattgaac aattagtata tggatttaca gctccattaa attacttgat atttactagt
    18721 gatataaata cagatattta taaatttgat ataaatatgg gactatcttc tttaattact
    18781 attataatag ctggatttat atattggtat agttctaaaa agtttaatat taaggtcatg
    18841 aactttgata aatatatagc aattttgatg attccattgt tgcttataat attatttatg
    18901 caatcatttg aatatagttc aaatataaat atagatacaa gtcttgggat tgtaaagctg
    18961 ctattaaata cttctataac tgaagaaatt caagcttttc ttttttctat aattggaact
    19021 atatgtgtat ttttttctct atttaccttt aagaaactaa ttcaagctct cgaagatgac
    19081 aaggagaggg caattatgaa tcaacagatt catgctcaaa aaaactatat tgaagaagcg
    19141 aaatcacgat tatcacaaac tatatccttt agacatgatt ttaataatca tttagctatt
    19201 gtcaatggat tgttgaaaaa agaccaaatt ttaaaagcac aagattattt aaataagctt
    19261 gaaaaagtaa caagtgacct atcattttct tgtaatacac agaatattgt tattgatgct
    19321 cttttcaaca ataaattaag tatagcaaaa caattaggca tagaggtaga ttgtgaagta
    19381 attatacccc aaagcactaa catgaacgat tttgacctat gtatagtgtt tgctaatgct
    19441 attgacaatg caattaaagc ttgtagagtt gtagataaac aaaataggta tttaaagctt
    19501 tccactaagt tagagggtgg attttttatg atagaaataa aaaatagcta taatccaata
    19561 aataattata caagtggctc aggtataggt cttttaaata taaaagaaat tgctaaaaaa
    19621 tatcaagggg ctataagtat agataagaca tcagactatt ttcaaataaa tgtattgcta
    19681 gttatttcat tacattgcgc tagtatttga gaacaatttc attgaaaata gtatttgtaa
    19741 gctatattat gtatttgaaa agagaaagtt tgatatatag aaatgaggag gttactaaaa
    19801 tgaaagttgg aaatataaat ggtcaagcac caattacaaa tggtttagat agttgtcaaa
    19861 gtgaggtaca aggcttagaa caaaagaaaa aagcattaca ggatgaaata gagaaagtaa
    19921 gaagtgataa aagtattgat ggtgaaacgg ccaaattaaa aatagaagct ttaaaaaaag
    19981 aaatggaaga gattgaaaat aaaattcaag agttaaaagg aaataaagga aaaaaaacaa
    20041 ataaagaaga aaataacgtt tcagaagtaa ataataatct attagagaga aaaaaagaac
    20101 cttctaataa tgaaaatgta aaacaattat atgatgtttt tgaaagaagc aatgtagacg
    20161 aacaatggga taatacttat cgtgttctcc aagatgataa aaacttaaaa gtaaaattta
    20221 atagacctat atagtttatt tataaaaata gttaatattt taattatcac cactttttag
    20281 aagaatacac actttatttt aaagacccac atatttattt acagttagca catttatatg
    20341 tggttttata actattattt acaagtctat attgataact tttacatagt atatgatgtt
    20401 taaatactta ttcaaattta tctatacata aacaaaaaaa gagattttaa aatctctttt
    20461 tagattgttg acttatggct ttttgattta ataaaatcaa gaagccgttt gaattttata
    20521 tgttggctga tacccttctg atattgaaac accatttttg tttccaaaat cgtttaaaat
    20581 taagaactta ttatgaatga ctatttcatt atgaacaata agcaaataac atgaatcttc
    20641 aatcaatgtt ttaacagtag cattaaatgc ttgcttatat agttctatcg tttgtttgaa
    20701 ctgcccatta aagtaaatat gagtcaataa cataactata tctacacaaa ttaatataaa
    20761 ttttttatac tgtacattat ctaactgttg attatctgta ttacaacatg attgaattta
    20821 aaaagccatc aacacataga atgttgatgg cctgaaaata gattttaaaa tctctttttt
    20881 attatatatt aattattttt taaatttata ttttttgcat cagattttct aatagctaag
    20941 tcaaaccctc taaatctaat cactataggg tcattaagag gagctatctt tttcacttca
    21001 acttcagtgc catctattag tcctaaggct agaagtctct tcataagttt ttcatttcca
    21061 gctatattgt ctataattcc cttttgtcca agttttaagt tgtaaacagt cattattaac
    21121 acctcctaat gaaaatcatt atcaaacttt atatttataa tatataacaa aaagagcaaa
    21181 ttgtcaatat ataacaaaaa ataaacatac taagttagta tgtttataaa aaatagtata
    21241 catgggatac taatagcatc tagcaaaaaa ccacttacta atggtacaac taaaaaggct
    21301 tttggagaat caccatattt ttgtgtcaaa gaactcatat ttgccagagc gttcggagta
    21361 gctcctattc catgtccaat caaaccactt attatgatgg cagaatcaaa atcttttcca
    21421 agtactctaa agcaaataaa tattgaaaat aggattataa agattacttg aaaagttact
    21481 attaagagaa taggaggtaa taatgtagat aattcaaata aatctatatt cataagtgat
    21541 aaagttaaaa aaattcccaa tgaaagttct tttaaaaaat ctataagttt aaaatttaat
    21601 tctagtatat ttatcttatc atttaaattt ctaaaaataa cagccgaaaa catacaagtt
    21661 acaacagagg gtaatagtat attaaacgtt atatagaagc atctacttat aatttctcct
    21721 gtatttatac aaataaatat gagaagaacc tgttccaaaa atacagatgg tgttattgtt
    21781 tcggagaagt tattattttt tatcctattc ttatttctaa aaaatttact tccaaatctc
    21841 tttagatttc tattatatct aggaatcgac aagtctatat ttgatgatgg ttttaattta
    21901 tatttattta ttagaaattt agctacagga catcccaata taccacccat aataagtcct
    21961 attgttgcag cagataatcc aaccccaact gctccttcta taccaagatt ttctattgta
    22021 agtccaaatg cagcagaata accatgacca ccttccatag atacatttcc acacataagc
    22081 cctaaaagag gttcaagttt tataatcttt gatattgtaa tagctaatat attttgacaa
    22141 aatgccaata ctccacacaa aatccaatat ctaaataata cactaccacc tttctttata
    22201 agatttatgc ttatttcaag tcctatagtt gtaaaaaaga aggttatgaa atttggcatt
    22261 aaatttccac ttatagatat atctgctata ttaaaatatt taaaaaataa atttagaaaa
    22321 caaaataata gacctcctat tactggtgca ggtatacaga aattatttaa aaagttaact
    22381 ttattcttca ataaattacc aattaaaaag aagaatatag atagtgtcaa ggtttgcact
    22441 atatcaaaac ttaaggtaat caaaataagt cctcctttgt aattcaaagt tttaattata
    22501 taacttaaat tcttatgtat tgaaatttta ttatcaaatg tatattaata aatgtatatt
    22561 aaaaagaatc agtagatata attagatagt cataaattaa attaaaatat tttaatgaga
    22621 tatgactttt ttagaattaa aaaccgtagt atattgatat aatagaaata agacttaaaa
    22681 atctgttgat agtattattt ataagtacag taggaggata aaatgtttga aaatttacct
    22741 aagatagatt tacattgcca cttagatgga agtgttagag tagaaaccat gcttgatata
    22801 gctattaaag agaaaataga tttaccttca aataatatgg atgaaataaa aaaattagca
    22861 aaggtttctt ttaattgtac ttcactagat gaatatttag aaaaatttga tttaccctta
    22921 aaagtaatgc aatctaagga aaatttaaaa agaattactt ttgaactttt ggaagatgca
    22981 agtagagaaa atgtaaaata tattgaaatt agatttgcac cattacttca cacccaaaaa
    23041 ggtatgagtg ttaaaaatat aattgagggt ataattgaag gaattagaga agctgaaagt
    23101 atttatgata taaaaggcaa tttaatatta ggttgtatga gaacaatgac ctcaaaagag
    23161 gcattattag taattgaaga agggaaatca tttgtaaata aaggtgttgt agcagtagac
    23221 ttgtgtggtc cagagaaaga gggattttgt aaggaatata aagatgtttt taaattagca
    23281 agagaatatg gatataaagt tacaatacat gcaggagaag ctgcaagtgg agaaaatgta
    23341 ttggatgcta taaatatttt aaaggcggat aggattggtc atggggtaaa aattaaagac
    23401 cataaaaagg cgtataattt agttaaagat aaaaaaatat tgcttgaatt atgtccaact
    23461 agtaatgtac aaactaagac agtagattct tatgaagcac atccatttta tactttttat
    23521 aaagataatt tacatgtaag tataaatact gataatagaa ctgtatcaga tataaattta
    23581 agttcagaac taaatgttat atttgatact tttaaactag gattagaaga ctataaaata
    23641 atttatagaa atgcagtaga agctagtttt gcagataaag aaactaaaga gtatttgaat
    23701 agtttaattt aatagataaa aatatttaaa ctttaaatta agctattaaa ttgataaaaa
    23761 tacattgtat taggagaaaa aatgtgaaag attatgaaga tgttgtttat attaaactag
    23821 tcaaaaaaga acttgaagaa tggaagaaaa atatattaaa gaaaccttct atatttgaca
    23881 aagcatcaaa gggtatacag aataaattta atggagtatt gccagataaa tatcatgaaa
    23941 taattacttc ttctataaaa gtaatgacaa aaaccgtact gtttggatat aaatatgcta
    24001 caaagccatc acttagaaat atgtcattag aagaaagaga aaaattagtt ttagaaaaag
    24061 ctaaaactta caagactaca gcaatgattg aaggggcagg aacaggggca ggaggaatcc
    24121 tcttaggttt atctgatttt cctttgcttt taggtattaa agtgaaattt ttatatgatg
    24181 tagcttcaat atatggatat gatgttaaag attatagaga aaggatttat atattaaata
    24241 tattacagtt ggctttttct agtcaacagc atataaacaa aacttttaaa ttgatgaata
    24301 actgggatga atatgtaaat agtctaccag aagacatcaa tgattttgat tggagaacat
    24361 ttcaacaaga gtatagggat tatttagatt tagctaagtt tttacaacta atgcctggaa
    24421 taggagcatt tgtaggattt tatgtgaatg gaaaattaat tgataaatta tgtgaaactg
    24481 ctgtgtctgc ttatagattg aggattcgag agcttaagtt ataagagaaa ttataacata
    24541 aaaaattagt tatacaatat atctatatgt atctaatttt gcattgataa aaacaattat
    24601 ggataaaagg taaagcatga tagaatctaa tgtagaggtt tgtattttaa tggaaaaatt
    24661 tagtttttat tgcttaagat acaaattgaa ttacgaagag aagtaattgg gaggaatatt
    24721 ttcatgacaa atttgccaaa acaatttgat agcttcaatg aagctagaca aaaaggattt
    24781 ataaatgcaa aggaacttaa ggaaagtggg aaaaagatgg ttggagtttt ctgtacattt
    24841 actccagttg aaattccaat ggcagctgga gcaactgtag taggtgtatg cggcgttagt
    24901 gaagagccaa tacctgatgc agaaagggtg cttccaagaa atctttgtcc tttaattaaa
    24961 tcaagctatg gacatgcaat aacagatacc tgtccttatt tctatttttc tgatttgttg
    25021 ataggagaaa ccacttgtga tggtaagaaa aaaatgtatg aagaacttgc aaaagttaag
    25081 ccaacatatg taatgcattt gccaaatact tcaaaaggag aatttgccta taaactttgg
    25141 aaagatgaaa tgataagatt aaaagaagag gttgagaaat ctttaggtgt aactataact
    25201 gaagaagata taagaactgc tataaaagat aaaaatgaag aaagagaact tttaaaagag
    25261 ttttatgcac ttggtaaatt acaaccatct gcacttacag gccttgagtt acataatgtt
    25321 ttatatcaag caggttttaa atttgaccgt gcagaactta aacattcttt aagaaaagtt
    25381 atagatgata tgaaagaaag atatgaaaaa ggtgaatgtc ctgttcaaaa agataagcca
    25441 agaatattga taacaggttc tcctattggt ggaataagcg aaaaaatagt taaaacttta
    25501 gaagatgcag gggcatcagt cgttgcatat gaactttgtg gagctattag atcaaacgat
    25561 ttattggttg atgaagaaat agaagatgta tatgatgctt taacacaaaa atatataaat
    25621 ataggttgtt cttgtatgat gaataatgac aatcgtattg aattattaga tagaataata
    25681 gatgaatata atgtagatgc tgtaatagat gtagttttac aagcatgtca tacatttaat
    25741 atagaaagtt atagaataag agaatttgtt acaaaagaaa aaaataagcc atttatgtct
    25801 cttgaaactg attattcaaa atcagatact gaacaattaa gaactagatt tgaagcgttt
    25861 gtagagatgt tgtaggaata aataaaagta ggaggaacta tgtttagtat aggagttgac
    25921 tcagggtcag tggcaacaaa gggtgtgcta tttgatggtg aaaaaattat taagaaaata
    25981 attataccaa ctggatggag ccctaaaagt acatctaaac aggtctatga gttgctaagt
    26041 agtgaaattg acaaaaaaga tataaaaaag gtggtaggta caggttatgg aaggggagta
    26101 atggattttg ctgataagaa agtaacagaa ataacttgtc atactagagg tatttacttt
    26161 ttaaacaaga acataaggac tattttagat gtaggtggtc aagatagtaa agttataaat
    26221 ttagatagag atggaaatgt atttaacttt ataatgaatg ataagtgtgc tgcaggaact
    26281 ggtcgatttt tagagattac ttctaacctt ttaggaagcg atattgaaag tatagataca
    26341 ttagctaaag gatatgaacc agttaatata tctagtatgt gtacagtttt tgctgagtct
    26401 gaaattgtaa gtcttctagc tcaaaacatt tctactggag aggtagcagc agggatactt
    26461 aaatctattg caaataaatc cacctcaatg ttagcaagag gtgaggtaat agatgaagtt
    26521 gcatttactg gagggcttgc aaaaagtaaa gaactagtaa aaatgataga agaaatactg
    26581 ggtaaaaaaa tttttattgc agaagatact caaataatag gagctttagg agctgctgta
    26641 ataggattta gataaaaaca tataaaagga aaatgagaag ctgaatttat tataaataaa
    26701 ttcagttttt tattttattt tatttattta taaaggaaaa ctttggtata attgatttaa
    26761 atgattgtat atttgtaaat acttgatatt tagtcatata taacattata attttaaaaa
    26821 ttagctcaaa ataaggggga gaaagcgtga aaaaatttac ttcaaaaaaa gtaacaaggt
    26881 ttgttgcgct gtttttaata tctattttag taatgtcaac aattcctgta tcagctgaca
    26941 atagcaatac attgaatcag ataaaaaaag cagaatacag tgagacgtat aaacaatatc
    27001 taaatgatgc taaaaatgga cgtacagaaa aatataatgg gattatacca aatccatatc
    27061 agttggaagg tactcaaatc caaagtaaag gaagaacagc tccaacatct tatgacccta
    27121 gaaaattagg tcttatgaca tcaataaaaa atcaagagga tttaggaatc tgttgggatt
    27181 ttgctgcaat ggcaacctta gaaagtttct taaagttaaa taattatgga gactatgatt
    27241 tatcagaaga acacttaaga tggtgggctt cagatggtga atatggatgg tctgtaaatg
    27301 atatgaatgg tgctttaaat tatgaagcta tgggatattt aacatcttgg tcaggtccta
    27361 aactagaaaa agatattcca tacaatggta gagtatctaa agcacaagga gcaaaaaaac
    27421 caactaatat gaatacagca cctactgttt ttaatgtgac agatgctgtg tgtgtaagta
    27481 atgacataaa ttctacaaaa aatgctatat tacagtatgg agcagtaaca tctggttatt
    27541 atgaagatat taaatatcaa agtgatgacc aaaattcata ttattgtcca acaaaaagtt
    27601 ttaatacaaa tcatgctatt tcaattgtag gttgggatga taactattct aaagataatt
    27661 ttaatgcaaa tattagacca tcaaaaaatg gtgcttggtt aataaaaaat agctggggag
    27721 attataattc tgagggtgga tatttctgga tatcttatga agacaagaca cttatgtctg
    27781 atatagataa tttttcaatc aaaggtggta aaaaaccaaa tgatgatgag aagatgtatc
    27841 aacatgacta tgcaagtatt gtacctttaa tttcaaaaaa gataacagct gcaaatgtat
    27901 ttgatttcaa tagaggcgat gaaactctaa aatctgtaat gttcttaact gaaagtatag
    27961 gagctaagta tgaagtatat tatgctccag tagtaaatgg tatacctcaa gaaaacaata
    28021 tgaaaaaatt aaaagaaggt actgcccaat attcaggata cataacagtt ccaattgatt
    28081 cttttgatat accagaagga aagggtgcaa ttgtagtcag tatagagggg aaaaatggag
    28141 agtcaactat aggttctgag tcaaatgtac caggatatga tacatttaaa gcaaaagcta
    28201 atttaggtga aagttatatc atagataata ctggaaaatt ctttgatata aatagagata
    28261 gtaacttcta tccgtgtaat tttactataa aagctgttac agaaaagtct tctggtgaga
    28321 gtatcccaaa tgagtcttta attggtagtg atagatatga aactgctatc aaagttagtc
    28381 aaaatggttt caattcttca gaaaatgtag ttttagtaaa tggcagttca atagtagatg
    28441 cattggcagc aactcctttt acatctgcta taaattcacc aatattattg acacaaaaag
    28501 aagctttaaa ttcaaaaact aaagctgaga tacagagatt aggtgctaag aaagtatacc
    28561 taataggtgg agaaaattct ataagtaaag aaattgaaca acaattaaaa agcttaaata
    28621 tatcgataga gagaatatca ggaagtgata gatacaagac aagtttatta ttagctcaaa
    28681 agttaaatgg tataaaaaat gtatctcaaa tagcagttgt aaatggagtg aaaggattag
    28741 ctgatgcaat tagtgtaggc gctgcagcag cagaaaataa cataccaatc atacttgcaa
    28801 atgaaaagag cgaattgcaa ggagctgatg aatttctaaa ttcattaaat atagagaaat
    28861 cttatattat tggaggaaca gcatccctat caaacaatct agaaagtaag ttaaaaaatc
    28921 caactagatt atctggtagt agtagagacg aaactaattc aaagataata gataattttt
    28981 ataaaaaaga tactttaaaa aatgcatttg tagttaaaaa tggaatcaag aatcaaaatg
    29041 atttaataga tggattggca gttggtcctt taggagcaaa aactgggtca ccagtaattt
    29101 tagttggtga taaattagct gatagccaaa aagaagttct taaaaataag actttagaaa
    29161 aagtaactca agttggtgga ggagcaaata aaaatgcatt taaagagtta gtaaaattaa
    29221 aaagtgctaa atagagtact taagtattaa catatattag tgtgtattag taacttatct
    29281 taataaaagc tgaaaataat tacttcaaat tattgataaa taagataatc aatgattgta
    29341 aagttttgtt ttcagcttta aatttatgta gtataagttt aaaaacataa aaaagggtta
    29401 ctttatatag aaatatagaa aatcttacat tttatatata aataacccat atttaattaa
    29461 ctttttatag tgttctaata gatattattg aacttaatgg taaatataat gtgtaagttt
    29521 catttaaagt tggattagat tcatctatat atcttgagca aagtgtaatt gataagctat
    29581 ctgcttctat aatttcacca tatagaggac aactgctaaa gtaagaatgt acttcaacat
    29641 atttatttaa gttttcttga acataatcgt aaaaacggtt ttttgtagta gtagccataa
    29701 aatcaactcc tttatttttt attaaagttg aaacttttaa aaagataaat atgattactt
    29761 ctattagaaa ctaagttaaa aaataagcaa atagatatga aaattagaat aatatattat
    29821 ttatatctta attataacac tagataataa aaaatgctat ataaaattca gaattttcga
    29881 aagtttttaa gcttattttt aaatatacta ataatactat tgacattaga tagaaaaagt
    29941 attatattga ctatataaat tattttagtc aaactggagg gaaaagatgc ctaaatcgta
    30001 ttctgataaa gaaagagagt atataataaa aagacttaaa gaagaagcaa gattgtgtat
    30061 ggagcaatat ggtattagaa aaactactgt tgatgagctt gtaaaacggg taaaaatacc
    30121 aaaaggaact ttttatctat tttttcaatc aaaagaattg ctcttttttg aggtattaag
    30181 agatatacat gactctatac aaaaagaaat cttatatgag ataaatagag tagatgaaag
    30241 tattacatgt gaacaattga cagatatatt tatgaaattc tataggatgg ttgatagtac
    30301 ttcaatttta aatcttatga taaatggaga atttgagata ttggtgagaa agttaccaga
    30361 ttctataatt gaagaacact ttagacatga tgactttgaa attggagaga ttatatcttg
    30421 cataccaaat gcaaaaaata aagacataga aagctttagt ggagcattta gagcagtttt
    30481 tcttaccatg ctatataagc gcgaggttgg aagtaattgt tttgaagatg ctttaagatt
    30541 aatgataaac ggattagtta tacaacttat ggaatagaat ttaaattttg tttgctaata
    30601 acttttatta aaaattatta acaaacaaaa aaattatatt ttattgacca tatagtcaaa
    30661 atagtcaaaa atttgaaagg gtgatattga atgattaaag ttgatgattt atcatttagt
    30721 tatacagaga gagatttttt acaaaatatt aactttggag taggaaaagg ggaaatacta
    30781 ggatttttag gaccatcagg tgcaggaaaa tctacattac aaaagattct aattggaatg
    30841 ataactaatt atggaggaag tgtcattgta aatggagtag agagtaaaag acactcaaat
    30901 aaattttatg aaaatatagg agttgatttt gaatttccta gtttatatga aaagttgact
    30961 gcaatagaaa atttaaaata ttttgggtct ctatattcta aaaaactact atctattgat
    31021 gagttattaa aatcagtagg actagaaaat gaagcaaata aaagggtatc tgagtattca
    31081 aaaggtatga aatctcgatt aaattttata aaagctttat tacataatcc agatatttta
    31141 tttttagatg aaccaacaag tggtcttgac ccatcaaata gcaaggttat gaaagatata
    31201 attttatcag aaaaatctaa aggtaaaact attattttaa caactcataa catgttagat
    31261 gcaacagagc tttgtgacag agtagcgttc attgtaaatg gtaaaatatc tgctttagat
    31321 acaccacata atcttattat gtcaaaagga gctattaaag ttagatatac ttactttgat
    31381 aatggagaaa aaacttctga atgttttctg aacaatactg ctaatgataa aaatttgaat
    31441 atgcttattg agaaaaataa acttttatca atacatagta gtgaaccaac attaaatgat
    31501 atttttattg agataacagg gaggaattta caatgaggct aaaaaatctt attttaggag
    31561 atataaagtt tcaatttaag tatggttttt attttttata tcttttttta agtattatat
    31621 atatttgtat tatcaatgta tttccaactt ttatgagaga aaaaatagct ataattatga
    31681 tttattctga cccagcagca atgggattgt tttttatggg agctattgta cttcttgaga
    31741 aaagtcaaag ggttttaaat tccttagctg tatctccagt aaaagtatct gagtatattt
    31801 tatcaaaggt aatttcatta ggagtaatat ctagtattgt agctatgttt attgctatta
    31861 cattaaattt agataatatt ataatatcaa ctataggtac ctttttttct tctattatat
    31921 tttctttgct tggattgata cttgcaagta aagcatctag tttgaatcag tttattgttt
    31981 taagtattcc tattgagatt atatgcttta ttccaccaat actcaatgta cttcttgaca
    32041 caaaatcata tgcaaatttg taccctttta atatatgtat ttctcttatt agtggagata
    32101 aaaattttat aatgattaat attttaattt taatatcaat tataataata atttatttta
    32161 taacttatta ttttatttgt agcagttgga aaaaggtagg tggagtaaaa ctatgataaa
    32221 gattataaat gcgtttaaac aagagtttga acaaattaag agagatgcta tgctttttat
    32281 agtatgtgtt tctccaatat tatgtggagt atttataaaa tttggaatac cattaataca
    32341 gaatatatca cttaacaagt tttattatca attaaattta gagccgtatt tcttgatgtt
    32401 tgatttactt ttagctttta ttacaccttt tatgttcttt tttgcttcta caatggtcat
    32461 attgggagaa attgatgaca gcatttcaag atatttaata gtaactccgc ttggtaaaac
    32521 tggttatctt atttcacgat ttggaatacc aggtatctta gcatttatta ttactatgat
    32581 tctacttatc tttttttctc taactaaaat ttctttcttg ttaaacttat caatttcttt
    32641 attagtttta ttacaaggaa ttattatatc aatattagtg atttctttat catcaaataa
    32701 actagaagga atggtaatta cgaaattctc aggtgttttt atgatgggta ttttagcacc
    32761 attttttatt ttaaataaag cacaatatat tctgttcttc ttaccaactt tttggatatc
    32821 gaaggcattt aaggaagata attatgtcta tatgtttatt tcaattgtta tatcattaat
    32881 atggatttta ttattattta aaaagtttag taaaaaaata gttaaataag aaaatttaat
    32941 atataaatgt aaggttgact tgacagtaat gttgaaaaat gttacattta agatgtaaag
    33001 ttaaccttac atgaatggag caaatatgaa aaataaaata aagatattaa gagaaaaatt
    33061 aggattgaca caagaacaac tagggagatt agttggaaca tctagacagg ctataaatgc
    33121 tatagaaact ggtaaaaatg aaccttcaat atggttggca tatgatattt caagaatttt
    33181 taatgaacca attgaaagtg tatttttatt tgaagaaagt gaaagaaaat caagagcaca
    33241 gataagtagg ggagaatatt atggctataa gaaagataag aacatttgat gatgaaattt
    33301 taagaaaaaa gagtaagtat gtagaaaacg tagataataa gataagagaa atattaaatg
    33361 acatggcaga gaccatgtac aatactccaa atggaggagg attagctgca tgccaagtag
    33421 gagtattaaa gcgattagtt gttatagatt taggagaagg acttattaag cttgttaatc
    33481 ctgaaattat taaacaagaa ggggaacaaa ttgttgttga aggatgttta agttttcctg
    33541 aagtatgggg taaattaaaa agaccaaaaa aagttacagt gcaagctcta aacgaatacg
    33601 gtgagaaaat agaaattaaa ggttcaggtt ttatggcaaa atgtctttgt catgagatag
    33661 accatttaaa tggtatagtt tttacagata aaattattga acatgtaaaa ttgtaagata
    33721 gattggttat tgaatttata aaatatttta tagtaaggag ttaaattatg agattatggc
    33781 ataaggattt aattgatgta ttacctaaaa atcaattagt aagtcaatgg agagagctac
    33841 ttgctataaa aggttctata gataaaaaag gtactccaaa ccatctatta gtgaataaag
    33901 tattgaatta tagtatagat gaatttaaat tttatacaaa aattgtacat gatgaaatgt
    33961 taaaaagaaa ttataaacct aatgaactta aatatacaag tatattaaaa tggaaaaata
    34021 gaaattttgc aaatgatata tctaatgaac atagtttaaa tttagaaaat ttatatgatg
    34081 attggcataa taaaatgtat ttaaagcaat gcttatataa tttagaagaa aaagcaacat
    34141 gtggaggaat accaataaat gaatggaata tattactttg taaatatagt aaagattatg
    34201 aattgtggtc tggaaatatc atgttttaat tactatagat taacattata gtattattgt
    34261 atataaagag gtgattattt gtataataaa ataaaatata ttccaataaa ttgtgaaata
    34321 gcttgtaata aattaaaaag gagtatgcca tataaatggg atttaaatat ttatcgtgga
    34381 tgtgagcatg gatgtaaata ttgttatgct atttactctc ataagtacat caactccaat
    34441 aattattttg aagagattta tgtaaaaaca aatatagtag aaaaacttga gagacaactt
    34501 aaaagcagta aatggaagaa agaagtaatc aatataggag gagttacaga tagttatcaa
    34561 ccaatagaag ctgactataa aattatgcca gaaatattaa acctgctaat aaaatacaag
    34621 acaccagcta ttatttctac aaagtcagat ttaattttaa gagattacga tttaattgat
    34681 aagctatcta ggattacata tatcaatgta gcatctacaa ttaccacagt aaatgaagat
    34741 acacaaaggc ttattgagcc aaatggtgtg gattcaatga gacgatttaa aatgttaaaa
    34801 gaatttagaa aaactaacgc atcagttggt ctacatatta tgccaattat accatatatt
    34861 acagatgatt ttgataatat aaattcgcta tttagacatg caaaagaatg taatgtacat
    34921 tatgttttac ctgggacttt atacttaagg ggtataacta gaggtgtttt ttttgacttt
    34981 gttaaaaaag agtttcctga attatttgat aaattatcaa tactatatag tgaaggttca
    35041 cttaataggg agtataaaaa tcaattgtat aaaatggtta atgaacttag atataaatat
    35101 tctctatcaa gcagttactc taaaataatg aaggaaaagt taaaaaactc aggagatgta
    35161 cagatatctt tttttgatta gttttatata aaaaaatttt ttttactatg atgattaaaa
    35221 tttattaaaa ttaaaattta ttgacaaata taaaatttaa atatataatt aattcataaa
    35281 ataaaaatat gaaaggatga tgttgttcgg tgatatttga tatcataaaa tcgttgatat
    35341 aagtattgct ggaaaagagt gaataaaatc aaatttaata agcaaacaaa gtaaagctat
    35401 agttttattg ttgtgcttaa aaatatttgg ttctatttta ctcttattta aactcatctt
    35461 tttgaagtta aaccacagag taaactctgt ggttttttta ttttaaaaat aaattttaag
    35521 gagtggtatg ttttgttaaa caaattatgt atgtatttag aaagaccaga gctttataaa
    35581 caaagtgaaa ttaatttttg ggatgatgag tatatttcag agcaattatt aaaagcacac
    35641 ttagacacta attttgaagg agcaagtaga aattttaact ttatcgagga ttctgtaaat
    35701 tggatagtta cagttgcaaa tccagttaat tatcctaaat tacttgattt aggttgtggt
    35761 ccaggtttat atgcagagaa atttgcacaa aaaggttata aggtaactgg aattgatttc
    35821 tcaaaacgtt ctattaacta tgcacaaaat agaaataagg agactaattt aaatataaat
    35881 tacttgtttc aaagttattt aaatatgaac tataatgagg aatttgattt ggctacctta
    35941 atttattgtg attatggagc tttgtcaact gaaaatagaa ggttattaat ggaaaaaatt
    36001 tatgatagtt taaaacctgg aggaaaatta atattagatg tatttacaat aaataaatac
    36061 aataattttg aggaaattaa atattgggaa ataaatgaag atggaggatt ttggagtaat
    36121 gaaaaatata tgtgtctaca agataattgt aaatacaatg attataatac attagaacaa
    36181 actcttgtaa taaccgaaaa agatgaaaat gtattttatg tttggaatca ctatttttca
    36241 aaagaaagtt tcttattaga agttgaaaat attggattta agtctgttga gttttttagt
    36301 aatgttaagg gtgaagcata ttctgacgat agtatgacta tgggattagt tttacaaaaa
    36361 taataatttt tttaaaatga ataaataaaa acttgaaacc tttaacaata aaataacata
    36421 agaaaagctt acatattgaa aaatggaaac ttttatgtta tttttagtac attacaaatt
    36481 tgtttatata aaaatcaata cttgaattat tatttttatg tgaaatttat ctatagtata
    36541 tttttataaa caagtaatgt tattaaaatt aagtatatag ttaaaagtgt atagcaaaaa
    36601 ggctgttata ttaatgttag aggttcaggg aaaatatata aagcaaagat atttacagat
    36661 aatgtagatt gcacagctat aagttagata atagaattat gtaatcaaga atttacaaca
    36721 aagtataaga taaggataat gctaaattgc catacaggtg ctagatgtgt aaatggattt
    36781 aattaatact attgataaag tgcaacaagc acataaacca attgatgaga ttattgaaac
    36841 tataagagat atagttgaca taattaaaat attggaacct gtttataatt ttaaatcaaa
    36901 tcaataatga ttaagattaa aataatatta aggcatcaat gttataagag tacaatataa
    36961 ggagtactat atagtactcc ttacttatac atattaggca atagggaatt tttttatagt
    37021 taaattttca aatatttttt agggaacttt ataattgaga attaagggta tagtatgtga
    37081 tgaacttact aaatttataa ttaggttata taatggaata atcatcaata gttttacttt
    37141 agggaaaata tatgcttaag gaagtatagc ttactaatat tattaaaatg tatatttaaa
    37201 atgataaaaa aagaattaga caagtattta gtaaattgac tatgcaaaat tctatcaagc
    37261 aggaacacta tgactttagt catgggaggt tcagtaggta acttgttgaa ttaagtttat
    37321 attatttaaa taaactactt aatttagata atataaaaag tcagaatttt aagaatagag
    37381 ctatataatc ttagctatta ggagaagtac tatgatagga atatatttta gtggaacagg
    37441 aaattcaaga tactgtgtag aaaaattttt acaagaatat gatataacag caaattctta
    37501 ttctattgaa gataatgaac ttttacagca catcaataat catgagaata ttatttttag
    37561 ttatcctgtg caatatagta atgtgccaaa aatattgaaa gattttataa taaatcattc
    37621 aactttgtgg aatggtaaac gtgtttttat tattgcaact atggctctat ttagtggaga
    37681 tggctctggt gtgttagcta gaatattaaa aaaatacggt gctataactg ttggtggatt
    37741 acatgtgaag atgccagata gtataggaga tgaaaaggta ttaaaacatt ctttagagta
    37801 taatagaaag cttgtaataa aagcagaaaa gaaagtaact aaagctgcta aaaaactgaa
    37861 acatgggtca ccaccaaaag aagggttggg ttttttgagt catattgtag ggttatttgg
    37921 acaacgattg tattttatca ataaaacaaa tatgtataca gataaactaa aaattaatac
    37981 tgaggaatgt attgtatgtg gtaaatgcgt taatttatgt ccaatgaaga atctagtaat
    38041 taaaaattgt atgattgttg caaatgggca atgtacaatg tgttatcgtt gtgtaaataa
    38101 ttgtgccaaa aaagcaatta cattgttagg taaaaaagtt gttgaacaga gtaatattaa
    38161 aaaatatatg taagaaattt aaagttttat tgaatgtaaa ttgatgtata ttttatgtta
    38221 gaaagagagg ttaaataatg gaatactaca tagttgattc atttgcaact aaactattta
    38281 aaggaaatcc tgctggagtt tgtgttcttg acagaagaat acctttagag ttaatgcaga
    38341 aaatagcaga agaaaacaat ttaccagaaa cagcatttgt agttaaatgt aaaggaaatt
    38401 atgaattacg atggtttact cctaaagcag aaattgattt atgtggtcat gcaactttag
    38461 cagcagctta tgtaatatca aattttattg atgttaatgt aaaaaggata gatttcttta
    38521 ctcaaagtgg aaagcttgaa gttacacgaa atggaaatct atatgaaatg atatttccag
    38581 aaataatgcc tattgaaata gagttatcac cacaacaagc taatttgata ggctgtgtac
    38641 caagtgctgt ttattcttca agagatttaa tcttattgct aaacagtgaa caagaagtta
    38701 taaattataa acctaattac gcacaattgc gtaaattgac agactggtta ggtataataa
    38761 tcacagcaca aggaagtaat acagattttg tatcaagata tttttgtcca gaattagatt
    38821 cagaagaccc tgttactggt tcatcacatt gtaatcttat tccatactgg tctgaaaagt
    38881 tgggaaaaca caaaatggta gctgctcaac tttctaatcg tggtggtata attcagtgtg
    38941 aagtgttgaa ggataatact gtaaaaattt ctggtgaagc agtcttgttt atgcagggaa
    39001 caataaagat tgatatttaa ataagtataa taactaattt attatgaaaa ataattaatt
    39061 ttcttagtgt taacaataat aaagtagagt taaaaagctt gatttcactt aaatcaatat
    39121 gatagatgtt gatactaaga ttgacaagca tgattaaaaa agataatatt taatctataa
    39181 agataaaaac acagtctggt tggtagtcca gacgcagcaa tagctgtcag taacctgcct
    39241 ccttggttgt ccgttcttta gaaagtaatt taaggaggaa ctagcaatgg acaaaattag
    39301 tggaaaatta acagttttat ttgaagaacc attttgggta ggtatatttg aaagacaaga
    39361 tggtaaaaaa tatgaagcat gtagggtagt ttttggagca gaacctaaag aagtagaagt
    39421 gtatgaattt atacttgaaa gatttttctc attagatttt ggtagcatta aattagaaaa
    39481 aaatgtgacc aaagacaaca ttggatacaa aagaatgcag agaaaagtaa aaaaggaaca
    39541 agaaaaagaa actataggga ctaaggctca aaatgctctt aagcttcaat atgaagaaag
    39601 aaaacaggat agaaaaaacc tagctaaaaa tagaaaagaa gaagaaaaag aaagactatt
    39661 taatttgaaa caagaaaaga gaaaagctaa acataagggt cattaatttt aattaaatat
    39721 ctttttaata attgctagaa aaaggtgtat aaaattttta attttataca ccttaattta
    39781 ttgaaaagaa taaggtttta tatttcaatt actttaaaat ataaaaatat actaataaaa
    39841 attgtaaaaa tagtataaat ggtataccaa atgtaaattt aatgtgttta gttttatgtc
    39901 taaaagaata cattccaatt atagaaccta tactacctcc aattactgct atagacataa
    39961 gagtagcttc ttttattctc cattcgtttc taattgctct tttcttatct atgtacattg
    40021 aaaagaaagc aatagaatta atcactataa aatatattag aataaaattt ttcacagtct
    40081 tgcctccata aaaatatatt atacattata aaacaagata tttgttttgg aaagttaaat
    40141 ttgtaattag tacatataaa atatttgata agaacaaata taatattaat tggaaaattt
    40201 aaaaaaatta aacaattagc aaataggggg tatatttata agacacaaag tgataaaatc
    40261 tatttagaaa ataatgtaaa ataacaggag gataaagcaa aatgaaattt atagtagaaa
    40321 aagaagtttt tgataaatta gaaaatgtat gctttggtgt agtagttgca aaaggaatag
    40381 ataatactaa agaaatagaa agaataagca accttttaga tataagtata gatagagtag
    40441 aagattactt caaagataaa aaagtaaagg aatcagaaga aattatacca tatagagagg
    40501 catttagaag tctaggcatg aacccaaata aatttatgag ttcgatagaa gcaatgacaa
    40561 caagggttgc taagaataag aaacttcctc atataaatcc tattgtagat ttaggaaact
    40621 ctatttcttt aaaatattta cttccaatgg gtgctcatga tatggatttt agaaatgatg
    40681 atgtatatgt tagattttct aaaaaagggg ataaatttgt accatttgga gaaactgatg
    40741 ttgaattaat ggaagaagga gaattaattt attcagttgg agacatggta aaaactagaa
    40801 gatggatatg gagacaagga gaggaaggaa aaattactaa tagctcaaaa aatatatttt
    40861 ttcctataga tggttttact gatgctaatt tagataaggt aatgagtgca agagaagaat
    40921 tagcaaaatt gttaaaggaa atatttaatt gtgaaattaa agtaggtttt gtagataaag
    40981 ataatcctga aatggaaata taataagttg ttgaatactt gttaagatat tatatttact
    41041 taatgatgtt aaaaaggtat taaaaaagaa aggtcgtagt aaatttgaaa aaaactataa
    41101 taaagaatgt aaatccaatg attgaaaata agtttatagg actttttgaa atagagtata
    41161 aaaacaaatt agatgaagat aaggtttgga tggtagcatc aagaaaaagt agtgagcaat
    41221 taaaaaatat ttatttgaag aatgaagaag atagtgtaga tgcagttgta atagttgggc
    41281 ttcataaaag tagtaaaaaa ttaattttaa taagacaatt tagagtacct attaatggat
    41341 atatatacga gttaccagca ggtcttgttg atgaaggaga gtctatagat atttccgttg
    41401 aaagagaact tagagaagaa acaggactta ctcttttaga aattaaaaaa aataaaagta
    41461 ttgataaagt ttatttatct cctggaatga gtgatgaatc tgttgccttt gtttattgta
    41521 tatgtgatgg tgatataaca gatgaatttt tagaaccaga tgaagagatt gaagcgcttt
    41581 taatttcgca agaagatgca aaagagattt tacaaagtaa tcataagata gacacaaaag
    41641 catttttgat tttacaaatg tttgtgagtt taggagctaa attatttgaa tagatatata
    41701 gaaaagaggt tatatagaag agtaaaataa taaagtttat tttacttgta taaattataa
    41761 tctctttttt tatacaataa agtataattt tgtgtatttt taaataagtg acttgactct
    41821 taaattttca taatatgtta taaaccaatt taagatacta caataattaa aattccaaaa
    41881 ttatttaaca tatttgcaat taaaatgaga aaaggtaaag gttgaatgat tgaaaaattt
    41941 gatgtaaaat agtagcttag tttaatatta tagtttgtag ggttaaaaat tagaaattgt
    42001 aagggagata aattctatga aaaaattagt tattatttta attagtatca ttagtatggt
    42061 tagcttgaca gcttgtaaaa aaagcaatga aagtaaatat aataatttaa acaacaaaga
    42121 atccggacaa acaaccattg aaatggactt agataaaaat tatgatactt cagacccatt
    42181 tgttaatgca cgtttgtttt gtgtgtctaa tgatatagat gttttagaca cagagatttc
    42241 ttttaaaatg gatggagata gtggtattgt ggaaataaag gacaataaaa catatgaaac
    42301 tttatggagt aatacatggc atggaagcgt tgataatgat acattcacaa tttctctttc
    42361 taatatacaa aaagagaaag agtatgctat atgctttact ggaattaaaa taaatcatgc
    42421 agttgtaaag gttacttttg aaagcaattt agttaaggag aaagaaaaac cctcaaaata
    42481 aattccagat tgtctataac ttgatattca gtacataaaa gcagttgata tttatgattg
    42541 actgcttttt cttatcaaaa aggagagttt gtgcattttt acttgaaata gtttatgcac
    42601 atcaaaagtt ggtgagcatg atattggaaa tggtaagcat gaaatcttga taagacaagg
    42661 aaataaattt aagttttcaa ttaagtatat ttccataatt tagttaacaa taagctaatt
    42721 attatttata ttttgatata taaataataa ttgtagcaaa tttcaaaaaa tcatatattt
    42781 tttgaactaa ataaaaattt atttttatta ttttaaatta gaggagattc ttgaagatat
    42841 attattttta aaaataagta tagtttaaaa attcaaaaaa aagatggcaa aatatgtccc
    42901 aagggacatt gagtaaaata aatgatttca gcttatttac actaaaaagt acatactaaa
    42961 tgaggggtaa aataaagaaa aatgatatac taattgtctt ttgataataa aaaaacatgg
    43021 aatttgatta tttaatcaag aaaaagtatt gaacaaatga tttatttagt gtacaataat
    43081 catgtaaaaa catagtaatg gagggagaca tttcataatg aaaattaagg taggaatgaa
    43141 cggatttgga agaataggaa gagctgtatt aagaatagct caagaagaat taggagataa
    43201 tatagaaatt gtagccataa atgcaagagc aacaacagaa tctttggcac atttatttac
    43261 atatgattca tgctatggaa cttttagagg tgaagtagag gcaaaggatg aagacactct
    43321 agtagtaaac tctaaagaga taaaaatatt aagatataat gacccagaag aattaccatg
    43381 gaaagaactg ggggttgata tagtaataga atcaacagga ttatttacac aaagagaaaa
    43441 ggcagaaaag catattaaag caggagcaaa aaaagtaatt ataacagctc caggaaaaaa
    43501 tgaagatata actatagtta tcggagttaa tgagaaagaa tatgataatg aaaagcacaa
    43561 tataatttca aatgcatctt gtactacaaa ttgtctagct ccttttgcta aagtattgga
    43621 cgaaaaattt ggtatagtaa aagggttaat gactacagta cattcatata ctaacgatca
    43681 aagaatatta gataaaagcc ataaagattt gagaagagca agagcagcgg ctgaatctat
    43741 aatacctacc actacaggag cagcaaaagc tgtgtcaaga gtactaccac aattagaagg
    43801 aaaattaaat ggtttttcac ttagagtacc aacaccaaca gtttcacttg ttgatttagt
    43861 gtgcgaactt aaagaaaacg ttacatctga gcaagttaac tctgtgttaa aagatgctgc
    43921 tgaaggagaa ttaaaaggtg ttttaggata ttgtgacaag ccacttgttt ctatagatta
    43981 taaaggagat tcaagatcat ctattataga cgctctatcc acaatggtta tagaagacaa
    44041 tatggttaag gtagtttctt ggtatgataa tgaatgggga tattcttcaa gaactgttga
    44101 cttagtaaaa tatgtagctg aaaaattaaa ataatatata tttcttaaag caaattttaa
    44161 aaaaattttt taaaaaaatt atataaaact aaaaaaaaag attatgaaaa atattgaagg
    44221 aaaaattttt tcataatctt ttttctttca tgcaaaaaga tacaagttac aacttatatt
    44281 tgcatattag gtcgttagag aagtatatat atatttagta aggaatcata ctttttataa
    44341 aatgaaagat aagatgtcga aaacttgcat aaatctgaaa aatttttatt attaaaatac
    44401 tgatttccat tttaaaaatg ataaaaaaat gacaaataaa gttgcaaata gtaatactta
    44461 taagtataat taaaaaagag aaaaggtttt gttaaacttt ataacaaaaa aagaagggat
    44521 gattcaaaat ggagaagtta acagacagga gacaggttaa ggcagtaagc atggaaacct
    44581 tcattttcct aatattacta gtagttggtt ttgggtatgt tggtagtatt atgggagcag
    44641 gaatgatgtt caaagtaata atgagtacag cacatgcttt actattggag acagttttct
    44701 taattatggc tatggcagtt cttgcaggcg cattaagcgc actactttca gagtttggag
    44761 taatagcgtt aattaataaa attttcgctg tatttatgaa gcctttatat ggactacctg
    44821 gtgctagtat agcaggagct ataacaactt atttatcaga taatccagct attatacctt
    44881 ttgctaaaga taaaacattc acacagtatt ttaaacaata ccaagttcca gcattatgta
    44941 acttaggaac agcctttggt atgggactta tcttaacaac atttatgatt tctcaaggta
    45001 cagaatatgt acttccagca ttaattggta atttaggtgc aattataggt agtgtcataa
    45061 gtgttagaat aatgttgaca tttactaaga agttttataa atacagtccg gaagaagata
    45121 aagcaacagg aacattagag aaaaaggatg aatttagaga aatcagagaa ggaaatgtat
    45181 ttcaaagagc tttagatgca attcttgaag gtggtaaaat gggggtagat atgggaatgg
    45241 ctataattcc tggagtccta gtagtatgta cattggtgat gttattaact tttggaccat
    45301 ctacagaccc tgttacaggt caagaagttt atacaggagc tgcatatgaa ggaataaaat
    45361 tacttccagt tattggagat aaacttggat ttatattaga accattattt ggatttacat
    45421 caccagaggc aatagcattc cctataactt cattgggagc tgttggcgca gcaatgtctc
    45481 tagttccaga gtttataaag tcaggagcta taactcctaa tgatatagca gtatttacag
    45541 ctatgggtat gtgttggagt ggatatttaa gtacacatat tggtatgatg gatgcattaa
    45601 atgctagaca gttggcaggt aaagctattc tttctcatac aataggtggt ttatgtgcag
    45661 gagcagctgc tcactttata tttacactcg taggataaat gtaatcagct aagataaaaa
    45721 ataatataca aaaaatggtt gttgatatgt aataagaatt tacatatcaa caaccatttt
    45781 tttctgacta aagataattt ataatacata aacattaagt ggatattaga gttaagttat
    45841 atttatgtaa aaagtaacaa aaatctgtag aaatttatga caaaatttag tacactaact
    45901 atatgttctt atttaaaatt taaggttaga attaggaatt acctagtaga gtaagctttg
    45961 attaataaaa gaatcataaa ataaaaatat tagtcataaa gattataaat aacttactta
    46021 aaataaagcc atagaactta caaaaattaa aaaagcatat aaatatggag gggtacaatg
    46081 gatgaattat ttcatatagg aattgatgta ggttctacaa cggtgaaggt tgtggtactt
    46141 aataatagta ataatatagt tcataaagaa tatagaagac attattctga tgtaaaaaaa
    46201 tcagttaaag aagtactaaa tggtatatat gaaaaattgg gagatataaa tactaccatt
    46261 ataataactg gttcaggtgg aattggaata tcaaaaaaat taggtgtaaa atttgttcag
    46321 gaagttatat ctagtacaaa atcaatagag tattttcatc ctgagactga tgttgtcata
    46381 gaacttgggg gtgaagatgc aaagataaca tatctaagtg gaggaataga ccaaagaatg
    46441 aatggaatat gtgcaggtgg cactggagca ttcatagacc agatggcatc actcttaaag
    46501 acagatgcca gtggattaaa tgaacttgct aaagggtata atgttatata tcccatagct
    46561 tcaagatgtg gtgtttttgc taaaacagat attcaacctc ttataaatga tggagccaat
    46621 cagactgata tagcaatgag tattttcaat gcagttgtcg tacaaactgt gagtgtcctt
    46681 tcttgtggaa gaaaaataga aggaaatgtt gcgtttttgg gtggtccatt gtacttttta
    46741 tctgaactta gagaagcatt taaaagagta ttagatttaa aagatgaaaa cataatcttc
    46801 ccagaaaatg cacaacttta tattgctatt ggagcaggat tattatcagt agatgaagat
    46861 aatatacaac taaaatctct aatagaaaaa ttggatagta taaagaatat tgaagatgga
    46921 gaagtaaatt tattagaacc tttatttaaa gataaaaatg agtatgaaga attttcaaga
    46981 agacatgaaa aagaaaaaat aaattatgtg gacataaatt caataaaaag caattgttat
    47041 ttaggaattg atgcaggctc aactacaact aaagcagcac ttattgatga ggatggaaga
    47101 cttgtatatt cttattataa tagcaatgaa ggaaatccat taaaaacaac cattaaagtt
    47161 ataaatgaag tatatgatat attaccaaaa aatattaaaa tattgagttc aactgtaact
    47221 ggatatggag aaggtcttat taaaaaagct cttaaaatcg ataatggaga gatagagact
    47281 atagcacatt acaaagctgc taaatttttc aacaaagatg tagattttat acttgatatt
    47341 ggtggtcaag atatgaagtg cctaaaaata aaagatggag taattgataa tataatatta
    47401 aatgaggctt gttcatcagg ttgtggctca tttttagaga catttgcaag ttctttatct
    47461 atgacaatag aagaatttgc gcatgaaggt atttattctc aaaatcctgt agatttaggt
    47521 tcaagatgta ctgtatttat gaattctaga gtaaaacaag ctcaaaaaga aggtgcaagt
    47581 gttggagata tatcagcagg gctatcttat tcagtaataa aaaatgcttt atttaaagta
    47641 ataaagatta gagatttaaa tgagattggt aataatattg ttgtacaagg tggaaccttt
    47701 tataatgatt tggtgcttag aagctttgaa aaactaattg gaaaaaatgt aattagacct
    47761 aatatttcag gaattatggg agcttttggt tcagcactta tagctaaaga aaaatatgaa
    47821 agtggataca aaacatcctt gttatctaag gaagagttga ataatatcaa gctagaagca
    47881 agtgtaacta gatgtaaagg ttgttcaaat cattgtcttc ttacaataaa taaattttct
    47941 gataatgaaa tttttatttc aggtaataga tgtgagaagg gtgaagctat ttatggtgat
    48001 aaaaaaatag gattagaaaa gaaaaaacca ataaatttat ttaagtacaa atacaataga
    48061 atttttagat acaaaccatt ggaaaaagaa gaagcaaaaa atggggaaat agggatacca
    48121 agagtattaa atatgtatga agattatcca ttttggttta cttttttcaa tgctatgggc
    48181 tttagagttg tactttcaga taggtcatca aaacagttat atgaaactgg tataactagt
    48241 attgcatctg aaacagtttg ttatccagga aaattagttc atggacatat agaaaattta
    48301 attgcaaaag gtataaaaaa tatattttat ccaagtgtaa caaatgaaaa taaagaggat
    48361 tcaaatgcag ataattatta taattgtcct gttgtaatat catattctga agtaataaaa
    48421 aacaatgtag agaatataag aaataagaac ataaattata taaatccatt tataagtcta
    48481 aatgataagg aaaaattgaa gaaaagactc tatgatgaat tatcaagaca tttttctgat
    48541 ataaaaataa ctaaagaaga agttaatcat gcagttgata aagctactga tgaacagaat
    48601 ttatttaaaa tggagataca agcagcaggt gaaagagcac ttaaagaaat aaaagaaaga
    48661 aatatgaagg ggattgtgtt atgtggaaga ccatatcata tagacccaga aataaatcat
    48721 ggaatgccag agcttataaa ttcattagat atggcagtgc ttactgaaga ctctatatgt
    48781 catttagcca atgtacaaag accacttaga gttgtagacc aatgggtata tcattcaaga
    48841 ttgtataaag cagctagttt tgtaagagat aaaaactatt tggaacttgt tcaacttaat
    48901 tcatttggct gtggattaga tgcagtaact acagaccagg ttcaagaaat acttaatgaa
    48961 aaatcgaaga tatatactat tataaagatt gacgaaggca acaatttagg agcagctaag
    49021 ataaggatga ggtccttaaa agcagctatg tttgagagag aaagcaaaaa tatagatgta
    49081 aaaaatataa aggtaaacag gatacagtat gctaaaaata atcagataac gaacaaacat
    49141 actatattag caccacaaat gtctccaata catttccaat tccttgaaaa agctgttaac
    49201 ttaagtggtt ataatataga aattctaaaa gatactgata gtagtgtaat tgaagaaggg
    49261 ttaagatatg taaataatga tgcatgttat ccagctataa tagttgtagg tcagctaata
    49321 acagcattaa aatctggcaa atatgattta aataacactt ctgttactat aactcagact
    49381 ggtggaggtt gtagagctac aaattatatt ggattcttaa gaaaggctat atacgatgct
    49441 ggatttaaag atgttcctgt cattgcactt agtgtaaatg gaatagaaga tagtggtata
    49501 atggataata tatcactaaa attaatcaat agactcttta tgtctgttgt ttatggtgat
    49561 ttgctgatga aagtactata tagagttaga ccatatgaaa aagttactgg aagtgcaaat
    49621 gctctatatg aaaaatgggt tgatatatgc aaatcttctc ttgttaaagc aaaaatttct
    49681 gtatttacta gaaatataaa agatatagta aaagaatttg ataatttaga gatactagat
    49741 atcaaaaaac caaaagtagg tttggttgga gaaatattgg tgaaattcca tccaattgca
    49801 aataataatt tagtagatat attagagcga gaaggtgctg aagcagtcgt gccagacctt
    49861 acaaatttct tcttaagttg tgcctttaat actatataca aacacactca tttagaagga
    49921 agtagaaaga gtagaatgat aggagaggca tttatataca taactggaat atatcaaaga
    49981 gtatataaaa aagcacttga taagagtgag agattttatg ctccagccaa tataaaaaat
    50041 gttgctaaaa gtacagaacc agtagtgtca ttaggtaatc aaactggaga aggttggctt
    50101 ttaacaggtg aaatggttga attattaaat gaaggtgtag aaaacattat ttgtatgcaa
    50161 ccttttggat gtttacctaa tcacataatt ggtaagggtt ctataaaaga attaaagagg
    50221 ttgtataaaa atgcaaatat aatacctatt gattatgacc cttctgcaag tgaggtaaat
    50281 caacttaaca ggataaaact tatgctttct aaggctttta aaaatatata agatttatat
    50341 tttgatatgt taaaagttaa tgaatttaaa aatatactct atattaagta tctataaaaa
    50401 agagttatcc tattttttag ggtaactctt tattagttaa aaaattatat gtatactgat
    50461 attaaagggg ggaagtaata tgagtttagt atatgatgtt tataaatcaa aattaggaaa
    50521 tttgtacata ttaagtgaag atggttttat agttagtata tacataggag atgaaaaatt
    50581 taataattta aaaaatgaat gtattaaaaa aggaattgat ataaagagaa gtaaggaaga
    50641 tttaaaggaa gcaataagcc agatagatga ttactttaat ggaaaaagaa aagtctttaa
    50701 tttaaatatt cgtattgaag ggactgaatt tcaaaaatca gtttataggg aaatgttaaa
    50761 aataccttat ggagaaacat tgtgttattc agatatagca agaaatataa acaatccaaa
    50821 atcagtaaga gcaataggac aagcaagtaa aagtaataaa attccaataa taataccttg
    50881 tcatagagta gttggcaaaa aagatattgg tggatatatg gggaatcatt ctgatttgaa
    50941 agagatacta ttaaatttag aaagacagag ttaacttaga aagaaatgtt tttattgtta
    51001 atatttgata taataatagt aaaaagaagt attttttaca aaaacaatga agaatttatt
    51061 ttaatttaca aaaatgaggg ggaattttaa tgtgtgataa agttatagca tcaaaatatc
    51121 atgagaaggg atttaattgt gcagaatcag ttataaaagc atataatgag gaatttaata
    51181 cagatatacc agtttgttta ggaagtggac tgggttcagg gtgtggggtt gctagtttat
    51241 gtggtgcagt aaatgcatca aatataataa ttggatatgt aaaaggcaga aaccacgaag
    51301 atgaaagtac taaagctaaa gtatatgcta aagatttaac tacaacagta agaaaagagt
    51361 atggttcaga gttatgtata gacctaaaaa aagatttagt tgcttgtaga gaaataatgg
    51421 atttcgcata tgatagtcta aaggaaactt taaaaaaaga attataagaa aataagctat
    51481 caaatataaa ttatttgata gcttattttt atagccgata ctaaataaat caaatatatt
    51541 ttagaattat tatttgtaaa taaacagcaa ataattttag gctttttatt taatatagtt
    51601 tttatttata tttatttttg aatatgttat actttgttta aataaatatt tgtaatgagg
    51661 gagatgagaa gattgaagaa tctcaattta cttattaata aattatattc aaaaaatcat
    51721 aatgaagcat ataaaacttt tttattctta gaaaatgaaa gtttaaaatc aaatattaca
    51781 tattgttttt ttgactcatt cctagaaatg attgataacg aaaactcata tattcgaaca
    51841 aggggattgt tattaatctc tgcaaatgct cagtgggata ttgataataa aattgaaata
    51901 aatatagata gtatactaag tcatatcgta gataaaaaac cttctgtatc aagaatgttt
    51961 attaaatcca tacctaatat tacaaagtat aaagaaaatc ttattaatcg cataaaaatg
    52021 gaattaagta atgcagatat aagtatttat aataataata tgaaaccatt agtagaaaag
    52081 gatataaacg atacattatc taatattagt taaatattaa tatagaaatt gaatattatc
    52141 tagttacaat tatttataac taagataata aaacaacaat ggtgctaatt tatatgtata
    52201 aattaattat gaaaaattta tataagtaaa atatattaac
//
LOCUS       DAEHWM010000019        51471 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.020, whole genome shotgun sequence.
ACCESSION   DAEHWM010000019 DAEHWM010000000
VERSION     DAEHWM010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 51471)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 51471)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..51471
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.020"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            14..643
                     /locus_tag="KNP36_001142"
     CDS             14..643
                     /locus_tag="KNP36_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2953 domain-containing protein"
                     /protein_id="HBF0873030.1"
                     /translation="MELNELFNFKYLIIAVIFIISVTMLILISHINILIIADIKNKDI
                     CLKLNIKYMFNLININRQLYPAENSKNNDKKEGMKNNIDSSILLADDLLSIYRLLKKI
                     KIHELYSNINFGTGNIGLTSSVYVLINTLYGNLFNMIDAEKMYLNVNPDFTKDYVLGN
                     IRIHIRPRIKALFNIIIMINKIMNKNKGNKEGDSNESNRFDTESYGNNS"
     gene            597..1025
                     /gene="ytfJ"
                     /locus_tag="KNP36_001143"
     CDS             597..1025
                     /gene="ytfJ"
                     /locus_tag="KNP36_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GerW family sporulation protein"
                     /protein_id="HBF0873031.1"
                     /translation="MRATGSIQSLMETTLETIKGSIDANTIIGDPIKTDTTVVVPISK
                     VTIGFGIGGGEYSKGYDDKDREIELKNEKSDTNFAGGSAGAISVQPVAFVVVESGETR
                     IMSLDSNINLVDNILSITPRVLEKIQNISQSNKNQDKNNM"
     gene            1273..1713
                     /locus_tag="KNP36_001144"
     CDS             1273..1713
                     /locus_tag="KNP36_001144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0873032.1"
                     /translation="MSDKELSILLLESMNNFHNLIKIINNERYKKDKVLTERQFFALV
                     KIRKHDKIELKNLSRDLHVSTSSLCILLNKLVEQEYVYREEDSRDRRNTFYGITKNGE
                     KILDNEILKFVSIISDKMDCLDINNKDKLFTSLEESKNIIEQLF"
     gene            1729..3180
                     /locus_tag="KNP36_001145"
     CDS             1729..3180
                     /locus_tag="KNP36_001145"
                     /EC_number="3.4.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucyl aminopeptidase"
                     /protein_id="HBF0873033.1"
                     /translation="MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNS
                     KENSIDTVTLVENNNLVNVCLVGFGKRELLNREKIRIIGGNLCKKLKNILKNEAYKSS
                     DVNVLNLNLNSDEIGCFVEGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQI
                     EKAKILANSTIIARNLVNEPSNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMD
                     AFFAVSRGSINKPRFIVMRYFGDKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTD
                     MAGAASVIGAMCAISQSKLKKNVIAVVAACENALSGGSYKPGDIISSMAKKTIEVLNT
                     DAEGRLTLADAIYYIINNEKVTKVVDVATLTGAALILLGNVATPIVTNNDDFYCELEK
                     AATLSGERVWKMPIYDEFKDMIKGEEADLKNTGGKNAGCITAGAFIGEFVGNTPWIHM
                     DIAGTSTSSKSIGYKAKGATGEPVRTLYYLAEI"
     gene            complement(3271..3939)
                     /locus_tag="KNP36_001146"
     CDS             complement(3271..3939)
                     /locus_tag="KNP36_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896207.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YwaF family protein"
                     /protein_id="HBF0873034.1"
                     /translation="MFKIFLFSSEQFVSLFIFGLFLYYCPKLTKNILPYSYTVEKIIC
                     TLLVIIMALEQLLLISSGNYSTLNSLPIGINYICIYLCIAILIFKQYHLFNIFFSWSL
                     VCSVGELIFSKNLGYEFPSLIYFIFIFSKCLIIYADIYMVDVRKFRVNRYALRDNLAI
                     CFIYFSFIFLLNTFTNSRYYYGFLSHSTTAIFTFIFVTSIMYIPALLFNRDTFILEKK
                     KKSK"
     gene            4208..4348
                     /locus_tag="KNP36_001147"
     CDS             4208..4348
                     /locus_tag="KNP36_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873035.1"
                     /translation="MGIIESASKLAEMVHLLAVEKGITDIEAWDEAVKEYSKIYEERR
                     NE"
     gene            complement(4523..4843)
                     /locus_tag="KNP36_001148"
     CDS             complement(4523..4843)
                     /locus_tag="KNP36_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like family protein"
                     /protein_id="HBF0873036.1"
                     /translation="MKLKTISLPELNNLDPTLESTFIKMGEEQGELAECIGKFRNLSG
                     ENNDLDEVDIIKKTAKELMDVAQTCVTMMFKLEEQYGINLDEIRKEHIKKLEKRGYIK
                     NMDK"
     gene            complement(4963..5700)
                     /locus_tag="KNP36_001149"
     CDS             complement(4963..5700)
                     /locus_tag="KNP36_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent protein deacylase"
                     /protein_id="HBF0873037.1"
                     /translation="MDANSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKL
                     NKQFTAEQLVSHTFFVRYPEEFFEFYKDKLIYPNAKPNNAHIALAKLEEMGKLKAVIT
                     QNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLGGNIPYCDNCGSIVKP
                     DVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYKGDYIALINKAN
                     TVYDKSASLVINKPIGEVLYEAVLRQI"
     gene            5915..7738
                     /gene="acd"
                     /locus_tag="KNP36_001150"
     CDS             5915..7738
                     /gene="acd"
                     /locus_tag="KNP36_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosaminidase"
                     /protein_id="HBF0873038.1"
                     /translation="MKKKAALATLAMLPLGVVNAHADGDIGIVTINYLNVRNEPTAES
                     SIAFVAKKDDKVLIKDSSNGWYKIKAESGQEGWASSKYIAKSNSDSLRTSTNKEKQVI
                     SNSLNMRNGAGTSYRVITVLKKGQKVEVISESNGWSKIKYDGRLGYVSSSYLGDVSNS
                     TNKSKTKQVNTTSLNVRSGPNTSYGLLGKLPKGSKVEVISEGNGWSKIKYNGKDAYVS
                     SMYLSDVSQSNSDNSSQSNDKKNTDKVVNTASLNVRSGPGSTYSKLGKVYKGSKVTVL
                     SESSGWAKINFNNKEAFVVGNYLSTSADTSNNNSNSNSDNSSNSNGNNSSSSGQVNGM
                     SGISGAKIDYKSLSYTLESHISKQVEKAASGGNVIAPSNRKSTPSPEFSTFSAQRTSS
                     FVNASSSDIEYYLNPKNFTNTTKGMMQFLKINSYRDGISESSLNSYLNGLSSSVFKNQ
                     GAAFINAAKKYNIDVVYLVSHAMWETAYGKSTLAQGQTLTSYKGQPLSKPVKVYNFFG
                     IGAIDKSANVSGAEAAYSNGWTSVEATIDGSAKWISQNYVNSSKYNQNTIYKMKWNYD
                     YTWHQYATDVNWANGISGIMENLIGLYGGGSSLVFEVPQYK"
     gene            7953..12251
                     /locus_tag="KNP36_001151"
     CDS             7953..12251
                     /locus_tag="KNP36_001151"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HBF0873039.1"
                     /translation="MESIKEYLDKLEINNSGLGKQLKEVYINRVVYFKEDKIVYFYLT
                     SKDIVSHELLDKFKEELMYKLDYFKDMRMKIRFTGLERKSNKDVIKKYWNNILYILKY
                     LCPSIAGWYKQVEFLCLEEELKIKLPKGIFYERLMKKNVTYVLKTVLSEELGLDLNIT
                     IEKAVDEKVNKERLIRINDREMEEKIRALEIGKVNNCEENEEESYVIKSDVDENLIYG
                     DNANAMIENIVELNASSGTVAVVGDIFDVDTKELKNGKILMIASITDYTSSISCKLFL
                     TDTNKDGVLENVKKGAYLKIKGDIVYDTYQREISMMISGIRKETRIEREDKSEEKRVE
                     LHAHTQMSSMDAICSVKKLVERAAKWGHSAIAITDHGVVQGFPDAMNAGKSNNIKILY
                     GVEGYLVEDDSLIIEDANDKELSQTFVVFDIETTGFSNTNDKITEIGAVKIENFKIVD
                     RFSELINPEKDISYKIQELTGITNELIKDKPTIEEVLPKFMEFVGDSVLVAHNAEFDT
                     GFISQKCREQGLLYNNKKVDTLMLARVMLPNLKRHRLNVVAKELGIPLLNHHRAVDDA
                     EATALIFNKFLQMLTEKGAKTLSDVNNILGKIDYTKLSTNHITLIAKNSIGIKNLYKI
                     ISDAHVNHFFRAPRILRSVLNEYKEGLIIGSACEAGVVFQAVKKNVSDEEMKKIIDLY
                     DYIEVMPIDNNRFMIDKGEVKDEEELRELNRKLIDTAKKFDKIPVATGDVHFLDKHEA
                     VLRKVLKYSQGFKVDEEETYLHFRTTDEMLEEFSYLGEELAYEVVVENSNLIADMVED
                     IKPIPDDTYPPIIEGSDVELREMCYKKAKRIYGDPIPEIVQKRLDRELNSIISNGYAV
                     MYIIAQKLVAKSLSDGYLVGSRGSVGSSFAATMSDITEVNPLPAHYICENEDCKYSFF
                     YEIGEWGSGVDLPDKDCPKCGRKLAKNGHDIPFEVFLGFEGDKEPDIDLNFSGNYQPT
                     IHKYTEELFGEGYVYRAGTIGTVAEKTAFGYARKYVEENNISVPNAEVLRLSNGCTGV
                     KRTSGQHPGGVMVIPDYKDVYDFTPIQYPANDTSCGVITTHFDYHSISGRILKLDILG
                     HDGPTIIRMLEDMTGINITEIPLDDKETMSLFTSTEALGVTPEEINCPIGCLAVPEFG
                     TKFVRQMLLDTKPTTFAELVRISGLSHGTDVWVNNAQDLVREDIVGLKDVISTRDDIM
                     NYLIFKGLPPKMSFTIMESVRKGKGLKPEHIEEMKKNNVPEWYIGSCKKIKYMFPKAH
                     AVAYVMTSFRIAYCKVHYPEAFYATYFTTKVEDFDADLIVKGLDAIKSKINEIESLGN
                     DATTKEKGMLTVLEVALEMYARGIKLLPVDIYKSDATEFIVVGEKTLLPPMAAIQGLG
                     GNAAINIQNERKNGEFISKEDLRKRTKISKTVIETLTNHGSLENMSERNQLSLF"
     gene            12455..12916
                     /locus_tag="KNP36_001152"
     CDS             12455..12916
                     /locus_tag="KNP36_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HBF0873040.1"
                     /translation="MKKNLEATIEEIVTKITDEHGFEMVDVEYVKEAGEYYLRVYIDK
                     EEGISLNECELVSRELSPILDEKDPIKENYFLEVSSPGLDRALKKDRDFVRYQGRDVD
                     LKLYKPLNGCKQFEGELVGLTEDNNIKIIANGKEMEFNRKDVAIVRLAIKF"
     gene            12946..14100
                     /gene="nusA"
                     /locus_tag="KNP36_001153"
     CDS             12946..14100
                     /gene="nusA"
                     /locus_tag="KNP36_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HBF0873041.1"
                     /translation="MNHEFMEALDELVVDRGIDKEILIDTIEQALLTAYKKNFGSAQN
                     VRVEFDRDKGDIKVFSQRVVVDESDLYDTFLEIELADAREINPNYELGDIIEHEVTPK
                     NFGRIAAQTAKQVVVQRIREAEREIVYNEFIEKENEIVTGEVARANKNVVYVNLGRIE
                     GIMTQSEQIPFENYKAGQKIKFYILEVKKTNKGPQIVVSRSHPGLVKRLFEEEVPEIY
                     EGIVQIKSVAREAGSRTKMAVRSIDEKIDPIGACVGPKGLRVKNIVDELGDEKIDIIK
                     YSEDPAEFISAALSPSKVVRVDIDEDEKSALVIVPDYQLSLAIGKEGQNARLAAKLTN
                     WKIDIKSESQAEQEMLNLENSKEIEAEDVEAEFIDQEELDTSEDNFSEEE"
     gene            14107..14388
                     /locus_tag="KNP36_001154"
     CDS             14107..14388
                     /locus_tag="KNP36_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HBF0873042.1"
                     /translation="MILKKVKKVPQRKCIACQDRDSKKELIRIVKNKEGKIFLDPTGR
                     ANGRGAYVCKSSECLKKAIKSKALNKAFKIDVPDEVYDNLLMELEEYEK"
     gene            14378..14689
                     /locus_tag="KNP36_001155"
     CDS             14378..14689
                     /locus_tag="KNP36_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal L7Ae/L30e/S12e/Gadd45 family protein"
                     /protein_id="HBF0873043.1"
                     /translation="MKNNKEKVLSFLGLATRAGKIVSGDDSTLLDLKKGKVNLILIAE
                     DASNNTKKLFKDKSTFRNIPYLFFSTKEEIGFAIGKSPRAVVGIKDENFSKKIIELIE
                     I"
     gene            14711..16651
                     /gene="infB"
                     /locus_tag="KNP36_001156"
     CDS             14711..16651
                     /gene="infB"
                     /locus_tag="KNP36_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HBF0873044.1"
                     /translation="MSKTRVYQIAEELNISNEELINKLAELDINVTDKDSVLEGEELE
                     LALEMLGEDLSQENGNVIEIDGKLTVQVLATKLDKSPSEIIMKLMKMGTMATINQEIS
                     FEIAALAAKDYGFELTVAESDDTEALEIEALMEIEEDKEEDLKPRPPVVTVMGHVDHG
                     KTSLLDAIRKTDVISGEAGGITQHIGASEVKINGHKIVFLDTPGHEAFTSMRARGAQV
                     TDIAILVVAADDGIMPQTVEAINHAKAAGVPLIVAINKIDKPGANPDKVKQELADQGL
                     LVEDWGGEVIAVPVSAKKKEGIDTLLEMVLLVAEMEELRANPNKRAVGTVIEAELDKG
                     RGPVATVLVQGGTLTVGDPIVAGVACGKVRAMINAKGKRVKTAGPSTAVEILGLSEVP
                     QGGDQFVEVPTDKIARSVAARRQQIVRDEMLKSTQRLSLDALFSQMSEGSIKDLNIVI
                     KADVQGSVQAVKQSLEKLSNEEVQVKVIHGGVGAVTESDILLAAASNAIIIGFNVRPV
                     PGAESLGEKENVDIRTYTIIYKAIEDIQAAMTGMLDPEYVDEETGKAEIREIYKISGV
                     GTVAGCYVTNGKIFRNCKVRLVRDSIIIHEGELAALKRFKDDVKEVNSGYECGMSFVN
                     YNDIKEGDIVEAYITKEVERKL"
     gene            16694..17074
                     /gene="rbfA"
                     /locus_tag="KNP36_001157"
     CDS             16694..17074
                     /gene="rbfA"
                     /locus_tag="KNP36_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HBF0873045.1"
                     /translation="MASYNRTRRIAEEIRKVVSTMLINGVKDPRITSMVSVTDVEVTN
                     DLRYAYVYVSILGGDEESTLTGLKSAGGYIRREVGKNIKLRYIPEIVFKLDDSIEKGM
                     YMDSLIKRVNEKNAQQNEDENYDE"
     gene            17055..18038
                     /locus_tag="KNP36_001158"
     CDS             17055..18038
                     /locus_tag="KNP36_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HBF0873046.1"
                     /translation="MKIMMNNMDSIINYIYEGDYFIVTSHISPDGDNIGSTLSMYYTL
                     KNLGKNVYYVLDDEAPLNLRFLVEDVKIYKSNEFNMKNYSLIALDCGDKMRICVSDEI
                     KNNASKLICIDHHASNDSYGDLNYVDIDASSTCELVYNLLVRFQQIKDINIINEDIAT
                     CLYTGLVTDTGNFSYSNVHASSFEMAKNLLVLGAQKNTIIQNIYQSNSSGYYKLLGEA
                     LKGLEIFDSKVSSIVLTQDMMNRNNISFNDVDGITTYTRDIKGIEVGILFKEKKQNEI
                     KVSFRSKNYVDVSEIAKLFGGGGHVRAAGCTIRDSIDNAKKMVLEAVLKSI"
     gene            18051..18956
                     /gene="truB"
                     /locus_tag="KNP36_001159"
     CDS             18051..18956
                     /gene="truB"
                     /locus_tag="KNP36_001159"
                     /EC_number="5.4.99.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HBF0873047.1"
                     /translation="MNKIISILKPTGMTSHDVVSRVRKILNIKKVGHTGTLDPDASGV
                     LPICIGKATKVCEVILNKDKSYICELTLGISTDTYDASGEILKKVDDFKFSNEDIERA
                     FDTQRGEINQLPPIYSALKVNGKRMCDLVRSGRQSEITLKTRRVNIKDIKILSIKGNK
                     VMFYVECSKGTYVRSICHDIGEYLGCGAHMSFLNRTSSGKFDLDNSITLEELELFYEN
                     KTLDKYLYDIDYVLDSFNYVVLNPNAIKYYSNGGSIDDKRFLKNNFDKDDEFVRVYST
                     DNFLGLGKLSKHNNTISVKSDKMFI"
     gene            19087..20016
                     /locus_tag="KNP36_001160"
     CDS             19087..20016
                     /locus_tag="KNP36_001160"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HBF0873048.1"
                     /translation="MVIIKSIKEIANIKESVITIGNFDGVHKGHQVLIGKTVEHAKKE
                     NIQSIVFTFANHPVNYFRPNSTKNIISNDDKIKLLEDLGIDIVVIIPFDEYMTKIPAK
                     DFVDEILVKKLKAKKIVIGHDFTFARAKEGNVNLLKSLEHEFGFEVEVIKPIKINDVR
                     VSSTYIRSLVSQGDMANVKEYLGRNYKLEGCVIHSKHLGRTIGFPTANIDLKNNMLVP
                     KRGIYASIVHIGDETYFGATNVGYNPTVNGKTLSIETNILEFDRDIYGENIIVEFLER
                     IRDERKFNSIDDLKNQLYNDTNYVYENYVCKNK"
     gene            20120..20377
                     /gene="rpsO"
                     /locus_tag="KNP36_001161"
     CDS             20120..20377
                     /gene="rpsO"
                     /locus_tag="KNP36_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002843739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HBF0873049.1"
                     /translation="MINKSEIIKEYGRAEGDTGSPEVQIALLTARINELNGHLKTHKK
                     DHHSRRGLLKMVGRRRNLLAYLKEKDLEGYRALIAKLGLRK"
     gene            20617..21462
                     /locus_tag="KNP36_001162"
     CDS             20617..21462
                     /locus_tag="KNP36_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBF0873050.1"
                     /translation="MKIKLVCDSLCDIPDEISEKDYIEIVPLTVIFNDREYIEGVDIK
                     KEEFYKKVKEIKQIPKTSQATYMEFKEVFDKFITEGYHIICMTGAANASGTFQSAMIA
                     KNDVNENEKIHIFDTRNLSLGSGQYVIKACELLEEGLGFEEIIDELENTRSSVRLLFA
                     PYTLDFLKQSGRVPVATALIGNMLNIKPIFFFDNGEAKLVNKVRGIKNIASKLVDIIL
                     EMNEGSLEGKIVTIGCGDNLHDCEILKDEVNKRIKARRVLFTRGGVSICSHTGPDILA
                     ISCSN"
     gene            21587..23698
                     /gene="pnp"
                     /locus_tag="KNP36_001163"
     CDS             21587..23698
                     /gene="pnp"
                     /locus_tag="KNP36_001163"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HBF0873051.1"
                     /translation="MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNT
                     TKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKREGKPSEKAILTSRLIDRPIRPL
                     FPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA
                     FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEF
                     IEGIVAEVGKEKMPVELYHAGEEITQLVREFATDKMKKAVQTFEKLERMENMDRVKEE
                     TLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDNRKLEEIRPIWCETG
                     MIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEA
                     RPSRGPGRREIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTL
                     SLLDAGVPIKDMVAGIAMGLIKHDGKVAVLSDIQGMEDHLGDMDFKVAGTEYGITAIQ
                     MDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKMQINPDK
                     IKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVG
                     KTYKGKVSRIMNFGAFVEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEID
                     EKGRVNLSRKVLLPKPEHKNK"
     gene            23964..24707
                     /locus_tag="KNP36_001164"
     CDS             23964..24707
                     /locus_tag="KNP36_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0873052.1"
                     /translation="MIMMVLNKSKLKKIIILILVVLLVLSGGVMVLKLFNNKPVFNLF
                     NGVDLPYERGTKDKSGYVALTCNIDLGWETEYVESILETLKKENVKITFNVTGKWAEK
                     NKDELLKIKKQGHEIGNHGYKHLDYSTLSYEDNYEQIETSKKIIEEIIGEKTKFFQAP
                     AGSFGPETVKAAKALGYTSIKWDADTIDWKYKDQPEVIIDRMKKKDIKDSSIILMHPT
                     NATTKCIDDIIAIVREKGLKAGKLSDVFK"
     gene            24865..26112
                     /locus_tag="KNP36_001165"
     CDS             24865..26112
                     /locus_tag="KNP36_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HBF0873053.1"
                     /translation="MYKTKILENGLTIIGEEIPYLKSITLGIWINAGSRIEEAQVSGT
                     SHFIEHMMFKGTKNRTSKEIASSIDNLGGQINAFTSKECTCYYVKLIDEHIDTGIDVL
                     SDMILNSKFDKNDIDKERLIILEELKMYEDSPDDLSYDLLVENIYANDGLGMNIIGTK
                     ESLYNITRESMLEYLNKYYIPNNAVISIAGNFNFDDMVEKIKSKFGHWEKKNLSIDIS
                     EAKFNPCFISKNKDTEQVNLAMCLKGIPFENDEEVYSMAVVNNIFGGSISSRLFQKIR
                     EEKGLVYSIYSSQTLYRKCGELGIFASMSTENLQDVYNLIKKEIENIRENYLTEKEIS
                     ESKEQLKGNYILDLESTSSRMMSTGKSMLLSKKVKTTDEILECINSVNINSIKKVVDK
                     VFNIENIGTCIVGRDVEKILHLD"
     gene            26147..26392
                     /locus_tag="KNP36_001166"
     CDS             26147..26392
                     /locus_tag="KNP36_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlmC/YmxH family sporulation protein"
                     /protein_id="HBF0873054.1"
                     /translation="MNLSEIAGKEIVNLVTGERLGVIGECDLILDETTGGILALLIPK
                     EKGFFARRKDKSFLEVPWRNVKKIGNDMIIIEYEGYI"
     gene            26402..27625
                     /gene="dapG"
                     /locus_tag="KNP36_001167"
     CDS             26402..27625
                     /gene="dapG"
                     /locus_tag="KNP36_001167"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HBF0873055.1"
                     /translation="MSILVQKFGGTSVESYEKMNEVCKIVKAYKKNDEELQLVLVVSA
                     MGRKGAPYATDTLINLCSAVNDEPSKRELDLIMSCGEIISGTILANLLNAQGIDSVFF
                     TGQQAGIITSDEYSNAKIKYINPKKVKRALDDGKVVVIAGFQGVTDDGEITTLGRGGS
                     DTSAVAIGKALECETVEIYTDVDGIMTADPRVEPNAKVLSFIDYEEVFQMADKGAKVI
                     HPRAVQLAKSGNITLAIKNTMNPTFEGTKIGSLCRHLEDNIEYEQERDFKVAVANKDS
                     VAQVKIKSAEEVFTEVLNEIEKKLITIDMINFFISEKAFVVEDADIKSLKEILDKFEL
                     DYEVNRDCAKVTLICSRIADEMSGIMSKVVRGLSKAGVSLLQTSDSNMTISCLVSEED
                     MHTAVHAIHQQFYLK"
     gene            27738..28472
                     /locus_tag="KNP36_001168"
     CDS             27738..28472
                     /locus_tag="KNP36_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit"
                     /protein_id="HBF0873056.1"
                     /translation="MKDYREDNERFDKDNCSEESSCEERECIKQFGTNEMPPQPPKDI
                     QCITIIGEIEGHFIGNPQKKATKYEHIIPMLYSIEESNDVKGVLVVLNTVGGDIEAGL
                     AIAELLNSTSKKVVTLVLGGSHSIGVPLATAGDYSFIAPTATMIIHPVRTTGLVIGIN
                     ETFEYFKKMQDRIIQFIIRTSNIKKDVLEKLMHEKDELVSDVGSVLIGKEAVDYGLID
                     EVGGLKEALKKLRELIKESEEEKNND"
     gene            28595..31006
                     /locus_tag="KNP36_001169"
     CDS             28595..31006
                     /locus_tag="KNP36_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HBF0873057.1"
                     /translation="MATKKKKKKKVNTLSFNAEYHNLITIFIGVFLLYSLNSNSMGWI
                     PVLMQNLFKGLFGGLSIAIPFIVIITGLLGFFDGNEYIYRLRKTKLYYIIILFIFVFY
                     GLLNAGTLPVDSPLKGNMFDDVMKLGVSGQGSGLIATTIAYYMSKIFGIAGGWLISIF
                     ALILSVMFIFNISIKDLVSNAKSKSKASKDSNLTFKDKIANMKKSAIDMMTDEVDDTT
                     INKKPGFFKGLMSKGLNNDDEEDEYFEEENSDGVDDKTIKIVGFNKAEDEYLEILEGT
                     QSMPELDVLKELQKATNENPVVDTKPEKKVDIAKPNLNIEKTQPMSIVAEPVNEDYSN
                     YKKPSIELLNKVNKKSDENGKKKVLKNASLLEKTLSDFGVEAKINQVTVGPTITRYEI
                     QPSPGVKVSKIVNLTDDIALSLAAKSIRIEAPIPGKSAIGIEVPNEEAQMVGVREVLE
                     SEEFNNFNSPLAMGLGKDVAGKIIIGDIGKMPHLLIAGSTGSGKSVCVNTLISSILYK
                     ANPDEVKLLLIDPKVVELANYNGIPHLLIPVVTDPKKAANALNWAVTEMNRRYKLFAD
                     AQVKDVTSYNEKAEEKLPKIVIIIDELADLMMASANDVEDYICRLAQMARAAGMHLIV
                     ATQRPSVDVITGVIKANIPSRIAFAVSSQTDSRTILDMGGAEKLLGKGDMLFYPLGAA
                     KPVRLQGAFISESESEKVIDFVKSQVKDGIKYEEDIIETISKVNTSKGSDEDEFLSEA
                     IEFVVESGQASASMLQRRFKIGFNRAARLIDSMEERGIIGASEGSKPRKVLISKQDLQ
                     NLEGE"
     gene            31009..32067
                     /gene="mnmH"
                     /locus_tag="KNP36_001170"
     CDS             31009..32067
                     /gene="mnmH"
                     /locus_tag="KNP36_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-selenouridine(34) synthase MnmH"
                     /protein_id="HBF0873058.1"
                     /translation="MSVIKIEKALKLDKVIFVDVRTEGEYEEDHILNAINMPLFKNNE
                     HNDVGTIYKMQGKHEAIQKGFDYVSYKLKDIYLQAAELALNYDNIVIYCARGGMRSGS
                     IVNLLSSLGVNVYQLEGGYKAYRNFVLEYLRHVMDTKNFVSVHGLTGTGKTDLLHLLD
                     EKGIDVLDLEGIAKNSGSTFGFITFDKKPPSQKNFETKLFESIFFSKENYIFVESESK
                     RVGSVTVPNEIFEAMTREGHHILLECDIENRVDRLCRDYIYDKDEGNILILKECINKF
                     RKRLGNKVVDDYIDLLESGEYKELVKRYLLEYYDPLYMHSVEKYKYSKIINFNDTQKA
                     LEDVIDLYESILEGESEC"
     gene            32061..33395
                     /gene="rimO"
                     /locus_tag="KNP36_001171"
     CDS             32061..33395
                     /gene="rimO"
                     /locus_tag="KNP36_001171"
                     /EC_number="2.8.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12 methylthiotransferase
                     RimO"
                     /protein_id="HBF0873059.1"
                     /translation="MLKIALESLGCSKNLVDAEIMMGILNNKGYKLIGDFEEADVIIV
                     NTCGFIESAKQESIDTIINFAELKKTGNLKLLIVTGCLAQRYSEELKTEIPEIDAIVG
                     TGSYQNIDKILKELSEMHKIVSLNDIEFVFNEDLPRYISTPSYMAYLKIGEGCSNNCT
                     YCIIPKLRGKYRSRKFEDIIKEAKKLAESGVKELVVIAQDTTKYGFDLYGKERLSELL
                     EELAKIDGFKWIRVMYSYPESITEELIQVIKKYDNICSYFDMPIQHASNNILKLMNRK
                     TTKEDILNKINLIRSNIPDAILRTTIIVGFPGETEDDFKQLVDFVEEVKFDRLGAFAY
                     SREEDTPADRLPNHIDEEVKIQRRDTLMMIQQKISEELNDKKIGKTYEVLIEEQIEDN
                     VYTGRTQGDAEEIDSIVYVKSVDNLEVGEFVSVQINDAMEYDLMGDVLYELA"
     gene            33382..33924
                     /gene="pgsA"
                     /locus_tag="KNP36_001172"
     CDS             33382..33924
                     /gene="pgsA"
                     /locus_tag="KNP36_001172"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HBF0873060.1"
                     /translation="MNLPNKLTLFRIFLIPVFVLIMLLNIPNKFLIACIIFIIASITD
                     ALDGKIARKYNLVTDFGKFMDPLADKLLVISALTCMIEDHLVSSWMVIIIVARELTVS
                     ILRAIAAADGKVIAAGNSGKLKTITQMVSIVFLLLGAQFENVLILNIGEILILIATLL
                     TLYSGWEYLYKNKELFMSSK"
     gene            34212..35258
                     /gene="recA"
                     /locus_tag="KNP36_001173"
     CDS             34212..35258
                     /gene="recA"
                     /locus_tag="KNP36_001173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HBF0873061.1"
                     /translation="MSVDQEKLKALNEALGKIEKDFGKGSVMKLGEATSMSIDVISTG
                     AIGLDIAIGIGGLPRGRIVEVYGPESSGKTTVALSCVASAQKDGGIAAFIDAEHALDP
                     VYAKALGVDVDNLIISQPDTGEQALEIAEALIRSGAIDIIVIDSVAALVPKAEIDGDM
                     GDSHVGLQARLMSQALRKLTGSIKKSNCVAIFINQLREKVGIMFGNPETTTGGRALKF
                     YSSVRLDVRKIDTIKQGDKVIGSRTRVKVVKNKVAPPFKQAEFDIMYGEGISKIGDLL
                     DIAADVDIVKKSGSWYSYNDTKLGQGRENVKKFLEDNLDLTTEIDEKVRAFYNLNEEH
                     EESGTSVSKEIVEE"
     gene            35434..36975
                     /gene="rny"
                     /locus_tag="KNP36_001174"
     CDS             35434..36975
                     /gene="rny"
                     /locus_tag="KNP36_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HBF0873062.1"
                     /translation="MDVIDSVVMIVIGAAVGIIAGYFVRKNISEAKIGQAENLAKEII
                     DKAHHDSETVQKEKLLEAKEEIHKWRTEAERENRERRTEVQKYEKRVVQKEEVLDRKL
                     QNLESKEVNLSEKLKVVEKKEEEVEVIKTQQLEKLESISGITSDKAKEIILTNAERDV
                     RREMSIMIKEIESQAKEEADKKSREIIGYAIQKCAADHVAETTVTVVSLPNDEMKGRI
                     IGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRREIARIALEKLIADGRIHPAR
                     IEEMVEKARKEVDNIIKEYGEQAAFETSVHGIHPELIRLLGRLNYRTSYGQNVLKHSI
                     EVAHIAGIMAAEIGADIRLAKRAGLLHDIGKAVDHEMEGTHVEIGMDLLRRYKESKEV
                     IHAMSTHHGDYEPQTVEAVLVTAADAISAARPGARRETLEAYIKRLEKLEEIANSYEG
                     VEKSFAIQAGREIRIMVKPEAINDEEIHLLARDMTKKIEDELEYPGQIKVSIIRETRA
                     IEYAK"
     gene            37289..39625
                     /locus_tag="KNP36_001175"
     CDS             37289..39625
                     /locus_tag="KNP36_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0873063.1"
                     /translation="MKKNTLLHTNIMVCIIITLGFVATSIIGYQSNTNIFKNDIEHVS
                     TLAAEGIYYQIDKLLSEPINVSLTMANDSLLKNFLDGEKEHLNDEEFIYKLQDYLNVY
                     RNKYSYDSVFLVSTKTNNYYHFNGLDRNLSANNSENQWYYTFLKNDDEYSLNVDNDEA
                     SNNSITVFVNCKIKDDNGATMGIIGVGLKVNSLQMLLKGYNDKFDVVARLIDDKGFVQ
                     LAVDKTGHENINFFENSSSDLSNSKQLILNNKKEQKSFWYSSEKSKSYIVCQYIPSLK
                     WHLVLENDFTLMIKQLHLQFFKGIAVIVLIIIFVLFTITHVLKKYKNQIIKLSVSQKL
                     EYQKLLSKSTEGLYENIFEIDITNNKAGCEDENRYFHEFGLGLNTPYDEALHTIAKNQ
                     IKEEYAQGYLDTFLPENVIKRYNSGINNISYDFLIKKDEESYHWIRINARIFFWTSDE
                     SVRMISYRKNIDEEKNRELLLLERSQRDSLTGLYNKATTEEFIRSFLKNESNQDLEHV
                     FLIFDIDNFKNVNDKYGHVFGDFVISEFALELKSQFREDDIVGRIGGDEFVVLIKDFN
                     NNNYVLIDKLERFCSKINQKKFVEQAEFSIACSIGVAMYPEHGYVYSELYEKADQALY
                     YAKSHGKNSYHIFSEDSIDSISFHIDSRDIKVLLEMATDGVVKFACMENLKLLYFNQK
                     MLEFTGYSAQTVTSIGFDIFSPVLQDDLQMVLDTLREAISKRETFEIVFRFCHTDGHI
                     FPVRMQGKFVSELYQNRYPVFYAIYTDISSINTLLENK"
     gene            40007..41788
                     /locus_tag="KNP36_001176"
     CDS             40007..41788
                     /locus_tag="KNP36_001176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="HBF0873064.1"
                     /translation="MSQYININSQLDALKLKEFEKIFYENINEDVKVVPKVTPFKGIN
                     TDLLYVKDGRILFIKFMDTTEDIFFILEEELLEVMNEEYELLKLKMGQKNRNISYNYV
                     YIMPYVEVEETYEFEEFVNNNIIDKNKLQDIMNKGSLEEYLNDENDEINLNLFLLDIC
                     SEYYIINDKLHLNEKFKKISFYNDDYKYTATMMEDVQIKDVVSIKYGNTLIEGGSGIG
                     KTAIMLSRAIKLAKVYPHHKLVIFTHTKQLCNELRERIELLYKDNNNLEVHTFSSFIF
                     KLAKKFNLIVDYNMLKNDYEKTFNNLVKQAQNIIKNKNMFKAIFIDEAESFLEYEIDF
                     IREFLYKTKFIFNVCSCNSLNISNRLNIFKKLYNGIEFDDKIILSKNYRQAKEIVDFT
                     NKFSNNSNSYINELRPNTEFSTFFYTKALRGGNKSVDIIKVSDLDDQISSVIWEIEYL
                     ISKKGLDYSEVAIVYPYNKKKLKSGKTIYFQYMLKKALEEAKIPYICAEDNLTNISKK
                     VGTTIANIYAIKNLEYKAVIVCELEMLYNQTINDIEQDYQVNDFVGDLNKVYLAMSRA
                     TDYLSIVTTFNEEASDIIRLITESKDI"
     gene            complement(41870..42400)
                     /gene="lepB"
                     /locus_tag="KNP36_001177"
     CDS             complement(41870..42400)
                     /gene="lepB"
                     /locus_tag="KNP36_001177"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBF0873065.1"
                     /translation="MSVKKEIFDWIKSIAMAIVLAFVILQFIRPSIVSGESMYPTLDD
                     KDYLILNRISYKVGKPEKGDIVVFKTNLVDGETGKKKDLIKRVIATEGDRIKISNSKV
                     YVNGKLLNEPYIHNNYTSGDIDTVVPKGKLFAMGDNRENSNDSRFPDVGMVDEDEVLG
                     KVMVRLLPLDNIGKVD"
     gene            complement(42440..43264)
                     /locus_tag="KNP36_001178"
     CDS             complement(42440..43264)
                     /locus_tag="KNP36_001178"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HBF0873066.1"
                     /translation="METFSLLEIFKAVILGIVQGITEWLPVSSTGHMILVDEFIKLNF
                     SNTFISTFLVVIQFGSILAVLVIFFRKLNPFDSAKNIKQKKETVRLWLKVIIAVIPSG
                     VIGILFEDDIDRLFFNSTVVAIALIVYGIIMIGLEKRNKKPKYKDFSQVTYKLALCIG
                     LFQCLALIPGTSRSGSTIIGAVLLGTSRYVAAEFSFFLAIPTMLGASALKLLKAGFGF
                     TGFEWLILGVGSVVAFVVSIVVIKFFMDYIKKHDFKVFGYYRIVLGIVVLAYFFLL"
     gene            43521..44429
                     /locus_tag="KNP36_001179"
     CDS             43521..44429
                     /locus_tag="KNP36_001179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBF0873067.1"
                     /translation="MYSTKILDDYEYETFNVFSTKLNPNTKHDYLSKVILFKEFLKGK
                     ELIYATKEDCKNFVDYIQTKYAKSTCEKIYSYLHSFYNFLKKEGYIDINPFRYVEKPT
                     VTRIKTKDDVLSIQEINKLIGILPKLNIRDRVIIVCLVTTGCLLNELVSLKWKDLMVD
                     ENDNSYVRLGKGRKERVVKLHPYFFKLLEDYRNYSGLPEVIIPSDDFIFTTQKSNSIT
                     DRNVRLIVKKALDLAGLSQYSARDFRHSFAAISLRLGADESDVKNQLGWSDKYYAIRY
                     KYVLNFVDSEIVDYLIEKDNLDINKK"
     gene            44573..46018
                     /locus_tag="KNP36_001180"
     CDS             44573..46018
                     /locus_tag="KNP36_001180"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HBF0873068.1"
                     /translation="MIDNKYTTYSNPLTDRYCSKDMSYIFSPQFKFSTWRRLWVALAE
                     GEHELGINITEEQLDELRANIDNINFDEARKIEKEVRHDVMSHVKAYGLQCEKAKGII
                     HLGATSAYVGDNTDVIQMNEALKLLRVKLVNLINNLKEFALKYKDMPALGFTHFQAAQ
                     LTTVGKRACLWAQDLILDLEDLNYRIDNMKLRGVKGTTGTQASFLSLFEGDHEKVKEL
                     DKKICKKMGYHSSYAVSGQTYTRKLDYQVISILSGIAQSMHKMTNDIRLLQSLKELEE
                     PFEKNQIGSSAMAYKRNPMRSERIASLSKYIISESISPAMVQATQWLERTLDDSANKR
                     LAIPQAFMAADAILEIGINVTDGLVVYENMINRRVNEELPFMATETILMEAVKRGGDR
                     QELHEIIREYSMKAAYRVKHEGKDNNLIELIMNDDSFKMSKEEILSIMDPKNFIGRAP
                     EQVVEFVNEVVEPAIKDYKEDLGKVDVDLRV"
     gene            46329..46781
                     /locus_tag="KNP36_001181"
     CDS             46329..46781
                     /locus_tag="KNP36_001181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0873069.1"
                     /translation="MNYIVKDTISFLVKTFPKIYSSLYLEDLKKFAPDYNVNKTQLRA
                     LVFIKNYGVISMTDLCSKLNIEKGSLTSMVDDLTDKKYVTRKRDLVDRRKYLIDITEE
                     GDKIATDFMDKLSDGLGEKLSKLTEEDRKKYLEAINTLQYILNKEEFR"
     gene            complement(47116..48312)
                     /locus_tag="KNP36_001182"
     CDS             complement(47116..48312)
                     /locus_tag="KNP36_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0873070.1"
                     /translation="MNYSNRVSAMQASPIRKLVPFAQAAKDKGIKVYHLNIGQPDIKT
                     PKGFFDAVKNFDSEVLEYATSEGIPELLEALQNYYKTYDMNFEKDELLVTNGGSEALL
                     FTMMAVCDPGDNLLVPEPFYTNYNGFGQSVNVEVNAVTTKAENGFHLPSKEEILSKVD
                     DKTKAIILSNPGNPTGAIYTKEELNILAEIAKEKDLWIIADEVYREFVYDGLEYTSCG
                     NLEGVQDRVIIIDSVSKRYSACGARIGSIACKNKGLIAQILKLCQGRLCVPTLEQIGA
                     VELYKTPVSYFKEVNEEYKKRRDVLYNELMKVEGVICKKPTGAFYIVAKLPVENAEDF
                     TIWMLKEFNKDNETVMVCPAEGFYATPGLGRDEIRLAYILNEKDLHRAATLLKEGLEQ
                     YVALQK"
     gene            48697..49647
                     /gene="galT"
                     /locus_tag="KNP36_001183"
     CDS             48697..49647
                     /gene="galT"
                     /locus_tag="KNP36_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="HBF0873071.1"
                     /translation="MKELRIDPITNDVVIFATDRLKRPLDTADIPNEDEETNEYDEEC
                     PFCKGNEAHATDALFEIDSEEGWLVKSVYNKFPIIDDMARDVYGVHEVMIESDKHNRS
                     FYNMSQKEFEDVFFMYRNRFRDLSKDDKVEYVSIFKNFLRKAGASLMHPHAQILSMSF
                     IPPEITNELLVSKEYYDSNKSSLYDDLIENEISLDRRVVYNGEAFLVLIPYATKYSGE
                     VRIIFKDKIEFGELNDNNIQELSTIFEKLFKKLYNINGYMPFNLCIHTHPTKIETKSY
                     FNVHMHIIPRKYNFGGFELGTNMYVSSMSPEDLTKKLKID"
     gene            49808..50560
                     /gene="xth"
                     /locus_tag="KNP36_001184"
     CDS             49808..50560
                     /gene="xth"
                     /locus_tag="KNP36_001184"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HBF0873072.1"
                     /translation="MKFISWNVNGIRACVGKGFLDFFKEVDADIFCLQETKLQEGQIE
                     LDLPGYFQYWNYAERKGYSGTAIFTKKEPLKVMYGINIEEHDKEGRVITLEFEDFYFV
                     TVYTPNSQSELKRLEYRTRWEDDFIDYLTKLDNHKPVIVCGDMNVAHKEIDLKNPKNN
                     MKNAGFTKEEREKFSKLLDSGFIDTYRYFNPDKEGVYSWWSYRFNARKNNAGWRIDYF
                     CASKKLEDRLVSADIHTEILGSDHCPVELEIK"
     gene            complement(50652..51428)
                     /locus_tag="KNP36_001185"
     CDS             complement(50652..51428)
                     /locus_tag="KNP36_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBF0873073.1"
                     /translation="MEYIIFDLEFNQGFDKKLNKTVSNEKCPFEIIQIGAIKLDSKFN
                     IIDTFNSYVKPTIYKDIHPFISRMTNIKSSDFNDSPTFPEVYNNFIKFISSQDPILCV
                     WGAGDLKELYRNINYHKLPSNSLPKSYINIQQHASKYFNNPAGKSIGLQNAISILELD
                     EKMSYHNALNDAYYTAKVFIKIYNPSIVPDIYLYTSIKPKTIRYSNKKRVDYDKLFDE
                     FRKILNRELTKDEKKIINLAYNMWKTNQFTLENVKQRKNK"
BASE COUNT        20667 a         5584 c         9180 g        16040 t
ORIGIN      
        1 tgataatata aacatggagc ttaatgaatt atttaatttt aagtatttaa taatagctgt
       61 aatttttatt ataagtgtaa ctatgttgat tttaatatct catataaaca tcttaataat
      121 agctgatata aaaaacaaag atatttgttt aaagcttaat ataaaataca tgtttaattt
      181 aataaatata aatagacaac tttatccagc tgaaaatagt aaaaataatg ataaaaaaga
      241 ggggatgaag aataatatag attcaagtat attattagct gatgaccttt tgagcattta
      301 tagattatta aaaaagataa aaatacatga actttattca aatattaatt ttggaactgg
      361 aaatattggc ttaacatctt ctgtatatgt attgataaat actttgtatg gaaatttatt
      421 taatatgatt gatgcagaaa aaatgtattt aaatgtaaat ccagatttca caaaagatta
      481 tgttttagga aatataagga tacatataag gccaagaata aaagctttat ttaatattat
      541 aataatgatt aataaaatta tgaataaaaa taaaggaaat aaggaaggtg atagtaatga
      601 gagcaacagg ttcgatacag agtcttatgg aaacaactct tgaaacaatt aaaggttcta
      661 tagatgcaaa tactattata ggagacccta taaaaacaga tactacagtg gttgtaccta
      721 tatcaaaggt tacaattggc tttggtatag gaggaggaga atactcaaaa ggatatgatg
      781 ataaagatag ggaaattgaa ttaaaaaatg aaaaatcaga tacgaatttt gctggaggta
      841 gcgcaggggc tatatctgta caaccagtag catttgtagt agttgaaagt ggagagacta
      901 gaataatgag tttagatagt aatatcaatc tagtggataa tatattatct ataactccta
      961 gagtattgga gaaaattcaa aatatatcac aaagtaataa gaatcaagat aaaaacaata
     1021 tgtaagaata aaatattttt aaatatgtat atagttttaa gtaaagtagt ggggttaata
     1081 taaatcccac tattttgttg tgtactttaa acatttatat ctaataagat tttagtttaa
     1141 aacaatttaa atagataata aagttgatat atagtataat tataaaaaga aaagaagtat
     1201 tatattatag atatataaac gcatttgaga tataagaggg agttataaat cattagtttt
     1261 gaggtgaatg ttatgagcga taaagaatta tctattttgt tgttagaaag tatgaataat
     1321 tttcataatt taataaagat tattaataac gaaagatata aaaaagataa ggttcttaca
     1381 gaaagacagt tctttgcctt agtaaaaata agaaaacatg ataaaataga gcttaaaaat
     1441 ctaagtagag atttgcatgt atctacttct agtctgtgta tactacttaa taaattggtt
     1501 gagcaagagt atgtatatag ggaagaagat agtagagata gacgaaatac tttttatgga
     1561 ataactaaaa atggagaaaa gatattggat aatgaaatac taaagtttgt atctataata
     1621 agtgataaaa tggattgcct agatataaat aataaagata aattatttac ttctttggaa
     1681 gagtctaaaa atataataga acaattattt tgaaaaggag aatttattat gaatataaag
     1741 tattctaaag aaatattaaa aagtttagaa aatgctataa cagtagtagc tctatttgag
     1801 ggagaagatg tttctacgac atttgataaa ataaatatga taagcagaaa ttttaattct
     1861 aaagaaaata gtatagatac tgtaacattg gttgaaaata acaatttggt aaatgtttgt
     1921 cttgttggtt ttggtaagag agagttattg aatagagaaa aaattagaat cataggtggg
     1981 aatttgtgta aaaaattaaa aaatatattg aaaaatgaag catataagag tagtgatgtt
     2041 aatgtactga atcttaattt aaatagtgat gaaataggtt gttttgtaga agggatatta
     2101 cttggaaatt ataagtttga taaatataag acaaaaagta aggattttga aagaaaagaa
     2161 gttgatacta taactatatt tactgaaaaa gaagttgagt gtcaaataga aaaggctaaa
     2221 atattagcta attcaactat aatagctaga aatctagtta atgaaccatc aaacgtaata
     2281 tatccaaaaa cattagcagt agaaacagtt aaacttggtg cagagtttgg gtttaatgtt
     2341 gatgtttatg aagaagaaaa aataaaggca ttgggaatgg atgctttttt cgctgtttca
     2401 agaggttcaa ttaataaacc aagattcata gtaatgagat actttggaga taaagaaagt
     2461 acagatatat taggtctagt aggtaaagga ttgacttatg atactggtgg atattcttta
     2521 aaatcaaatg cttctatgct agatatgaag acagatatgg ctggtgctgc gagtgttata
     2581 ggtgctatgt gtgctatatc tcaaagtaaa ttaaagaaaa atgttatagc agtagtggca
     2641 gcatgtgaga atgctttatc aggaggttca tacaaacctg gagatataat tagttctatg
     2701 gcaaagaaaa ctattgaagt tttaaatacg gatgcagaag gtagacttac attagctgat
     2761 gcaatatact acattataaa caatgaaaaa gtaacaaagg tggttgatgt agctacatta
     2821 actggtgctg ctttaatatt gttaggtaat gtcgcaactc ctatagtaac aaataatgat
     2881 gatttttatt gtgaattaga aaaagctgcc actttatcag gggaaagggt atggaagatg
     2941 ccaatttatg atgaatttaa agatatgata aaaggagaag aagcagacct taaaaacact
     3001 ggtggtaaaa atgctggatg tataacagca ggagctttta ttggtgaatt tgttgggaat
     3061 actccttgga tacatatgga tatagcgggg acaagtacat catcaaaatc aattggatac
     3121 aaagcaaagg gggctacagg agaacctgtt agaacattgt actatttggc agaaatctaa
     3181 aaaacaatta taaaatataa tttataaagc cacgtggata tttttgtaat ttaagattat
     3241 ctatgtggct ttatttttta tttaaataaa ttatttactc tttttctttt tttcaagtat
     3301 aaaagtatct ctattaaata aaagagcagg tatgtacata atactagtaa caaaaataaa
     3361 cgtaaaaata gcagttgtgc tatgacttaa aaaaccataa tagtacctag agttggtaaa
     3421 tgtgtttagt aaaaatatga atgaaaaata aataaaacat atagctaagt tatctctaag
     3481 tgcatatctg ttaactctaa attttctaac atcaaccata tatatatctg cataaattat
     3541 caagcactta gagaagataa agataaaata tattaagcta ggaaattcat agcccaagtt
     3601 tttagaaaaa atgagttctc caactgaaca aactaaactc caagaaaaaa atatattaaa
     3661 aagatgatac tgcttaaaaa ttagtatggc tatacacaga tatatacaaa tataattgat
     3721 tccaattggt aaagagttta gagtactata attacctgaa gaaataagta ataattgctc
     3781 tagagccata attattacaa gtaatgtaca aattatcttc tcaactgtat agctataagg
     3841 taaaatattt ttggttagtt ttggacaata gtataaaaat aatccaaata taaagagact
     3901 tacaaattgt tcactagaaa aaagaaaaat tttaaacata taacattctc tcctataata
     3961 aatttaatat gtatctatat aaatatattc attatatctc aatttaatat ataaaaaaga
     4021 taataatagt tagatttttt atatgaattt taataggtaa aatatcctat tgttttgtag
     4081 atatatccta attatgtcaa aaaataaaaa aatttttatt tattagagtt tttggaaata
     4141 ataataacag atattataat taattaacag tttttgtaag tatttgacaa tagagagggt
     4201 gtaacaaatg ggaataatag agtcagcatc aaaattggct gagatggttc atttattggc
     4261 tgttgaaaag gggataactg atatagaagc atgggatgaa gctgtgaaag aatacagcaa
     4321 aatttatgaa gaaagaagaa atgaatagaa tgataaaaaa tgaaaacttg atgataaaaa
     4381 ataactttat ttaaagaaat tcaattttta tagaagtatt aaaaataata taaataaaaa
     4441 gatggtattt caaatgtaag taaaaaatca ttttgggata ccatccttat tatttatttt
     4501 aataatatat aagtaataaa tcttacttat ccatattttt tatgtaacct cttttttcta
     4561 acttttttat atgctcctta cgtatttcat caagattaat accatattgt tcttctagct
     4621 taaacatcat agtaacacat gtctgagcta catccattag ttccttagca gttttcttta
     4681 taatatcaac ttcatctaaa tcattatttt ctccacttag atttctgaat ttacctatac
     4741 attcagctaa ttcaccttgt tcttcaccca ttttgataaa tgtagattct agtgttgggt
     4801 ctaaattatt aagctctggt aaagatatag tttttagttt cataaaagct cctttcaagt
     4861 tattcgtatt tatactaaaa catcataaca aaaataatac taaaaaaaaa ctttaaattc
     4921 aacataaaaa cttacatata taataaaaat cgtgaaataa atctatattt gtcttaatac
     4981 agcctcatat aaaacttctc caataggttt atttattaca agagaagctg acttatcata
     5041 gactgtattt gctttattaa taagagcaat ataatcacct ttgtaataat ctataaaact
     5101 tgctgctggg tacacagcta atgatgtacc tcctataatc aataaatcag cattacttat
     5161 agcagaaatt gttttagtaa tgacatcact gtcaagagct tcctcataaa gtactacatc
     5221 tggttttact atagaaccac agttgtcaca gtaaggaata ttacctccca gatttaacat
     5281 agattctaag tcaaaaaact taccacattt agtacaataa tttctatgta cagaaccatg
     5341 aagttctagc acatttttac ttccagccat ttgatgaagt ccatcaatat tttgagttat
     5401 gacagcttta agcttaccca tttcttcgag ttttgctaaa gctatatgag cattattggg
     5461 ttttgcatta ggatatatta atttatcctt ataaaattca aaaaattctt ctggatatct
     5521 aacaaaaaaa gtatgtgaaa ctaattgttc agcagtaaat tgtttattga gtttttggct
     5581 aaataatcca gtagaacttc taaagtctgg aatattagat tcagttgaaa cacctgctcc
     5641 accaaaaaat acaatattat tgtgattagc tattaagtct tttaagctat ttgcatccat
     5701 agttacacct ccaaattatt atatataaat tgtactacat attaggtcgt ttatgtttta
     5761 ttaatttaaa taaatatata gtttaataag ttaaataaag ggaatataaa taaaatgtat
     5821 acagagtata aatagacaat atttactaaa ataacaagtt gtcgtataat tatattaaaa
     5881 ttgttttagt gtataagaag ggcgggggaa gtacgtgaag aaaaaagcag ctttagcaac
     5941 attggctatg ttacccttag gtgtggtaaa tgcacatgct gatggagata taggtatagt
     6001 gactataaat tatttaaatg taagaaatga accaactgcc gaaagtagca tagcctttgt
     6061 tgctaaaaaa gatgataaag ttttgattaa agactcttct aatggatggt ataaaataaa
     6121 agctgaatct ggacaagaag gttgggcttc atcaaaatat atagcaaaat caaatagtga
     6181 ctctttaaga acgtctacaa ataaagaaaa acaagttatt tcaaatagtt taaatatgag
     6241 aaatggagca ggtacaagtt acagagtaat aactgtacta aaaaaaggtc aaaaagtaga
     6301 agtaatatca gagagtaatg gatggtctaa aatcaaatat gatggaagac taggatatgt
     6361 atctagctct tatttaggag acgtttcaaa ctcaactaat aaatcaaaaa ctaaacaagt
     6421 gaatacaact tcactaaatg taaggagtgg accaaataca agttatggtt tgttaggcaa
     6481 gttgccaaaa ggaagtaaag tagaagtaat atcagaaggt aatggatggt ccaaaataaa
     6541 gtataatgga aaagatgcct atgtatctag tatgtactta tcggatgtaa gtcaaagtaa
     6601 ttcagacaat tctagtcaaa gcaatgataa aaagaatact gataaggtcg taaatacagc
     6661 ttctttaaat gtaagaagtg gaccaggttc tacatatagt aagttgggaa aagtttataa
     6721 aggaagtaaa gtaactgtac tatcagaaag tagtggatgg gctaagatta attttaacaa
     6781 taaagaagca tttgtagtag gcaattattt atctacttca gcagatactt caaataataa
     6841 ctcaaatagt aactctgata acagttctaa tagtaatggc aataattctt catcatcagg
     6901 tcaagtaaat ggtatgtcag gtataagtgg ggctaaaatt gattataaat ctttgagtta
     6961 tactttagaa tctcatataa gtaaacaagt tgagaaagca gcatcaggag gaaatgtgat
     7021 agctccaagt aataggaaaa gcactccaag tcctgaattt agtacttttt cagctcaaag
     7081 aacaagctca tttgtaaatg caagttcaag tgatatagaa tattatttaa atcctaaaaa
     7141 ttttacaaat actactaaag gtatgatgca gtttttaaag attaacagtt atagagatgg
     7201 tatttcagaa tcaagtctta actcgtatct taatggttta tcttctagtg tatttaaaaa
     7261 ccagggagca gcctttataa atgctgccaa gaagtataat atagatgttg tatatctagt
     7321 atctcatgct atgtgggaaa ctgcttatgg taagtctaca cttgcccaag gtcaaacatt
     7381 aacatcttat aagggacaac ctcttagtaa gccagttaaa gtatacaatt tttttggtat
     7441 aggagcaata gataaaagtg ctaatgtttc aggtgcagaa gcagcgtatt ccaatggctg
     7501 gactagtgta gaagctacaa tagatggctc tgcaaagtgg atatcacaaa attacgtaaa
     7561 tagttctaag tacaatcaga atactatcta caagatgaag tggaattatg attatacatg
     7621 gcatcagtat gcaactgatg tgaactgggc taatggaatt tctggaatta tggaaaattt
     7681 aattggtctt tatggaggag gaagtagttt ggtttttgaa gttcctcaat acaagtaata
     7741 cataaataaa aaatatagac tatgggtagt tttcatttta tttaaattat ctatagtctt
     7801 tttgtatata atttataatc tgtaaattta atgctaacaa aacttttatg ttataatatt
     7861 aattctaagt aaatataagt gagtaatagg tagaaataga taaaaagtgg taataatata
     7921 tataaagata attttgagaa aggaggatat atatggaaag tattaaggaa tatttggata
     7981 agttagaaat taataatagt ggtcttggaa agcaacttaa agaagtttat ataaatagag
     8041 tagtttattt taaggaagat aagatagttt atttttatct aacttctaaa gatattgttt
     8101 ctcatgaact tttagataaa tttaaagaag aattgatgta taaactcgat tattttaaag
     8161 atatgaggat gaagataaga tttactggtc ttgaaagaaa atccaataaa gatgttataa
     8221 aaaaatattg gaataatata ttgtatatat taaagtatct ttgtccatct attgcagggt
     8281 ggtataaaca agtagaattt ctttgtttag aagaagaatt aaaaataaaa cttccaaaag
     8341 gtatatttta tgagcgatta atgaaaaaaa atgtaactta tgtacttaaa accgtgctta
     8401 gcgaagagtt gggattagat ttaaatataa caatagaaaa agctgttgat gaaaaggtaa
     8461 ataaagaaag actcataaga atcaatgata gagaaatgga agaaaaaatt agggctttag
     8521 aaattggaaa agttaataac tgtgaagaaa atgaagagga aagttatgtc attaagtctg
     8581 atgtagatga aaatttaatc tatggagata atgcaaatgc tatgattgaa aatatagttg
     8641 aattaaatgc atcttctgga acagttgcag ttgttggaga tatatttgat gttgacacta
     8701 aagaacttaa aaacggaaaa atacttatga tagcttcaat tacagattat actagctcaa
     8761 taagctgtaa acttttttta acagatacaa ataaggatgg agtacttgaa aatgttaaaa
     8821 aaggagcata cttaaaaatc aagggtgaca tagtttatga tacatatcaa agagaaatta
     8881 gtatgatgat tagtgggata agaaaagaaa ctagaataga gagagaagat aaatcagagg
     8941 aaaaaagagt agaactccat gcacatacac aaatgtcttc tatggatgct atttgttctg
     9001 ttaaaaagct tgtagagcgt gcagccaaat ggggtcattc tgctattgct ataacagacc
     9061 atggtgttgt acaaggattt ccagatgcta tgaatgcagg taagtcaaat aatataaaaa
     9121 tactttatgg agtagaaggg tacttggttg aagatgattc tctcattata gaggatgcaa
     9181 atgataaaga actttcgcag acatttgttg tatttgacat agagacaact ggtttttcta
     9241 atacaaatga taaaataact gagattggtg ctgtaaaaat agaaaacttt aagattgtag
     9301 atagatttag tgagttaata aatcctgaaa aagatatttc ttataagata caggaattga
     9361 caggaataac taatgaatta attaaagaca agccaaccat tgaagaagtt cttcctaagt
     9421 ttatggaatt tgttggagat agtgtattag tagcacataa tgcagagttt gatactggat
     9481 ttatatcgca aaaatgtagg gaacaaggct tgttatataa taacaaaaaa gtagatacac
     9541 ttatgttagc aagagtaatg ttgccaaact taaaaagaca tagattaaat gtcgttgcaa
     9601 aagaacttgg tattcctctt ttaaatcacc atagagcagt ggatgatgct gaagctacag
     9661 cacttatatt taataagttt ttgcagatgc ttacagaaaa aggtgcaaaa actctaagtg
     9721 atgtaaacaa tatacttgga aagattgatt acacaaagct tagcacaaat catataacct
     9781 tgatagcaaa aaattctata ggtataaaaa atttatataa aataatttca gatgcacatg
     9841 taaatcattt ttttagagca ccaagaatcc ttagaagtgt attaaatgaa tataaagaag
     9901 gattaataat tggttcggct tgtgaagctg gggtggtttt tcaagctgta aagaaaaacg
     9961 tgtctgatga ggaaatgaaa aaaataatag atttatacga ttatattgaa gtaatgccta
    10021 tagataataa tagatttatg attgataaag gagaagtaaa ggacgaagaa gagttaaggg
    10081 agttgaatag gaaattaatt gatacagcca aaaaatttga caaaattcca gtagctactg
    10141 gggatgttca ttttttagac aaacatgaag ctgtcttaag aaaagttctt aaatattctc
    10201 aaggttttaa agtagatgaa gaagaaactt atttacattt tagaacaaca gatgaaatgt
    10261 tggaagagtt tagttatctt ggagaagaat tggcatatga agttgtagtt gaaaatagta
    10321 atctgattgc cgatatggtt gaagatataa aacctatacc agatgatact tatcctccaa
    10381 ttatagaggg ctcagatgtg gagttaagag aaatgtgtta caaaaaagcc aaacgaatct
    10441 atggagaccc aataccagaa atagttcaaa aaagactgga tagagaatta aattcaataa
    10501 taagcaatgg gtatgcagtt atgtatatta tagctcaaaa actggttgca aaatctcttt
    10561 cagatggata tttagttggt tcaagaggct cagttggctc atcttttgca gctactatga
    10621 gtgatataac agaagttaat cctcttccag cacattatat ttgtgaaaac gaagactgta
    10681 aatattcatt cttttatgaa ataggtgaat ggggctcagg tgttgattta ccagacaagg
    10741 attgtccaaa gtgtggaaga aaacttgcta aaaacggtca tgatattcca tttgaggttt
    10801 tcttaggttt tgaaggtgat aaagaaccag atatagactt aaatttctca ggaaattatc
    10861 agccaacaat tcataaatac acagaagaac tatttggaga ggggtatgta tatagggctg
    10921 ggactatagg tactgtagca gaaaaaacag cttttggata cgcaagaaaa tatgtggaag
    10981 aaaataatat aagtgtacca aatgcagaag tacttaggct ttcaaatgga tgtactggag
    11041 taaaaagaac ctcaggacaa catcctggtg gagttatggt tataccagac tataaagatg
    11101 tatacgattt tacacctata cagtatccag caaatgatac ttcttgtggt gttataacta
    11161 ctcactttga ttatcattca ataagtggta gaatacttaa acttgatata cttggacacg
    11221 acggtcctac cattataagg atgcttgaag atatgactgg aataaatata acagaaattc
    11281 ctttagatga taaagagact atgtctctat ttacatctac agaagcatta ggtgttacac
    11341 cagaagaaat aaactgtcct ataggttgcc ttgctgtacc agagtttgga actaagtttg
    11401 tacgacaaat gttacttgac acaaaaccta ctacatttgc agaacttgta cgtatatctg
    11461 gtctctctca tgggacagat gtttgggtaa ataatgcaca agacttagtt agagaagata
    11521 tagttggatt aaaagatgtt atatctacac gagatgacat aatgaactat ttaatattta
    11581 aaggattacc tcccaaaatg agctttacaa taatggagag tgtaagaaaa ggtaaaggtt
    11641 taaaaccaga acacattgaa gaaatgaaaa aaaataatgt tccagaatgg tatataggct
    11701 catgtaaaaa gattaagtac atgttcccaa aagcacatgc tgttgcttat gtaatgacat
    11761 catttagaat tgcatattgt aaagttcact atccagaagc attttatgcg acttatttta
    11821 cgacaaaagt tgaggatttt gatgcagatt taattgttaa aggattagat gctataaaat
    11881 caaaaataaa tgaaattgag tcactgggaa atgatgcaac cacaaaagaa aaaggtatgt
    11941 tgaccgtttt agaagttgct cttgaaatgt atgctagagg aataaaatta ttaccagttg
    12001 atatatataa atcagatgca actgagttta tagttgtagg agaaaaaaca ttacttccac
    12061 caatggcagc aatacaaggt cttggaggaa atgcggctat aaacatccaa aatgaaagaa
    12121 aaaatggtga atttatatca aaagaagatt tgagaaagag aacaaaaata tcaaaaacgg
    12181 taatagaaac tcttactaat catggttcac ttgagaatat gagtgagaga aatcaattgt
    12241 cattgtttta agttagccca aaaagttgca aataaaagaa ttttatgata tcatagtata
    12301 gaaaatagta tactttgcag aaactaagag tgagacagct gttctcactc ttttatttta
    12361 aatatattat taaaaagctg gtttattttt attaaatata ttttatttaa gattatataa
    12421 actggtcatt tacaattgaa taggaggaac tttaatgaaa aaaaatttag aagctacaat
    12481 tgaggagatt gtaactaaaa taacggatga acatggattt gaaatggttg atgttgaata
    12541 tgtaaaagaa gcaggagaat actacttaag agtatacata gataaagaag aaggaatatc
    12601 tttaaatgaa tgtgaattag ttagtagaga attaagtcca atactagatg aaaaagaccc
    12661 tataaaagaa aattactttt tagaggtatc ttctccaggg cttgatagag cattaaaaaa
    12721 agacagagat tttgttagat atcaaggtag agatgtagat ttaaaattat ataaaccatt
    12781 aaatggatgt aagcaatttg aaggtgaact tgtaggatta acagaagata ataatataaa
    12841 aatcattgca aatggtaagg aaatggaatt taatagaaaa gatgttgcta ttgtcagatt
    12901 agcaataaag ttttagtggt atattaaata gggaggatat aaaaaatgaa tcatgaattt
    12961 atggaagcat tagatgaatt agtagttgac agaggtatag ataaagaaat acttatagat
    13021 actatagaac aagctctttt aactgcatac aagaaaaact ttggttcagc acaaaatgtt
    13081 agagttgaat ttgatagaga caagggagat ataaaagtat tttctcaaag agttgttgtt
    13141 gatgaatcag atttatatga tactttctta gaaatagagt tagcagatgc tagagagata
    13201 aaccctaatt atgaattagg tgatattata gaacatgaag ttacacctaa aaactttgga
    13261 agaattgcag ctcaaacagc aaagcaagta gttgttcaaa gaataaggga agctgagaga
    13321 gaaatagtgt ataatgaatt tatagaaaaa gaaaatgaaa tagttacagg agaggttgct
    13381 agagcaaata aaaatgttgt ttatgtaaat cttggaagaa tagaaggtat aatgactcaa
    13441 agtgaacaaa taccatttga gaattataaa gcaggtcaaa aaataaaatt ctatatactt
    13501 gaagttaaaa agactaacaa aggacctcaa atagttgtat caagaagtca tccgggtcta
    13561 gtaaagagat tgtttgaaga agaagttcct gaaatatatg aaggaatagt tcaaataaaa
    13621 tctgtagcaa gagaagcagg gtcaagaact aaaatggcag taagatctat agatgaaaaa
    13681 atagacccaa ttggagcttg tgttggacca aaaggactta gagtaaaaaa tatagtggat
    13741 gaacttggcg atgagaaaat agatataata aaatatagtg aagacccagc agagtttata
    13801 tcagcagcac ttagcccatc aaaggttgtt agagtagata tagatgaaga tgaaaagtct
    13861 gccttagtaa tcgttccaga ttatcagtta tcgcttgcta taggtaaaga aggtcaaaat
    13921 gcaagactag cagcaaaatt gactaactgg aaaatagata ttaagagcga atctcaagca
    13981 gaacaagaaa tgttaaatct tgaaaattcc aaagaaatag aagctgagga tgttgaagct
    14041 gaatttatcg accaagaaga gttagatact tcagaggata attttagtga agaagagtaa
    14101 ggagggatga ttttgaaaaa agtaaaaaaa gtgcctcaaa gaaaatgcat agcatgtcaa
    14161 gatagagact ctaaaaaaga gcttataaga atagttaaaa ataaagaagg aaaaatattt
    14221 ttagacccaa caggaagagc caatggaaga ggagcatatg tatgtaaaag ctctgaatgt
    14281 ctaaaaaaag ctataaagag taaagcatta aataaagctt ttaaaataga tgttcctgat
    14341 gaagtctatg ataatctact tatggagtta gaagaatatg aaaaataata aagaaaaagt
    14401 actttcgttc ttagggctcg caactcgtgc agggaaaata gtgtctggtg atgattcaac
    14461 tttgcttgac cttaaaaaag gaaaagtaaa tttgatttta atcgcagaag atgcatcaaa
    14521 taatactaaa aaacttttta aagataaatc aacttttaga aatattccat atctattttt
    14581 ttcaacaaaa gaggaaatag gatttgcaat aggaaaatct ccaagagcag ttgtaggaat
    14641 aaaagatgaa aatttttcta aaaagataat tgaactaata gaaatttaaa ataaaatagg
    14701 gggtgatctt gtgtcaaaaa caagagtata ccaaatagca gaagaattaa atatatcaaa
    14761 tgaagagctt ataaataagt tagctgaatt agatataaat gtaactgaca aagattcagt
    14821 attagaaggt gaagagttag aattagcact tgaaatgtta ggtgaagatt tatctcaaga
    14881 aaatggaaat gttatagaaa tagatggaaa gttgacagta caagtattag caacgaaatt
    14941 agataaatct ccatcagaaa taattatgaa gcttatgaaa atgggaacta tggcaacaat
    15001 aaatcaagag ataagttttg agattgctgc tttggctgcc aaagactatg gatttgaatt
    15061 aacagtagct gaaagtgatg atacagaagc tttagaaata gaagctttaa tggaaattga
    15121 agaagataaa gaagaggatt taaaacctag accaccagtt gttacagtta tgggacatgt
    15181 tgaccatggt aagacatctt tactagatgc aataagaaaa actgatgtga tttcaggtga
    15241 agctggagga ataactcagc atataggtgc ttcagaagtt aaaatcaatg gacacaaaat
    15301 agtattttta gatactccag gacatgaggc tttcacatca atgagagcaa gaggagcaca
    15361 agttacagat atagcaatat tagtagttgc agcagatgat ggtataatgc ctcaaacagt
    15421 tgaagctata aaccatgcta aagcagcagg tgtaccttta atagttgcta ttaataaaat
    15481 agataaacca ggtgcaaacc cagataaggt taaacaggaa ttagcagacc aaggattatt
    15541 agttgaagac tggggtggag aagtaatagc agttccagta tcagctaaga aaaaagaagg
    15601 aatagataca cttttagaaa tggtattatt ggttgctgaa atggaagagt taagagctaa
    15661 tccaaataaa agagcagtag gaactgttat agaagctgag cttgataaag gaagagggcc
    15721 agttgcaaca gtacttgttc aaggtggtac tttaacagta ggtgacccaa tcgttgcagg
    15781 tgttgcatgt ggtaaagtta gagcaatgat aaatgcaaaa ggtaagagag taaaaacagc
    15841 aggaccatct acagcagtcg agatattagg tctatcagaa gttccacaag gaggagacca
    15901 atttgtcgaa gttccaactg ataagattgc tagaagtgta gcagcaagaa gacaacaaat
    15961 agttagagat gaaatgttaa aatcaactca aagattatca ctagatgctc tatttagtca
    16021 aatgagtgaa ggttctataa aagaccttaa tatagttata aaagcagatg tacaaggttc
    16081 agtacaggca gttaaacaat ctttagaaaa attatcaaat gaagaagttc aagttaaagt
    16141 aatacatggt ggtgttggag ctgtaacaga atcagacata ttacttgcag cagcttctaa
    16201 cgcaataata ataggattca atgtaagacc agttccaggt gcagaatctc taggagaaaa
    16261 agaaaatgtt gatataagaa catatactat aatatacaag gcaatagaag atatacaagc
    16321 ggctatgact ggtatgttag accctgaata tgttgatgaa gaaacaggaa aagctgaaat
    16381 aagagaaata tataaaatat ctggtgttgg aacagtagct ggatgttatg tgactaatgg
    16441 taagatattt agaaattgta aagtaagatt agttagagat agcataataa tacatgaagg
    16501 tgagcttgca gcacttaaga gatttaaaga tgatgtaaaa gaagttaatt ctggatacga
    16561 atgtggtatg agttttgtaa attataacga cataaaagaa ggcgatatag tagaagctta
    16621 tataactaaa gaagtagaaa gaaaattata aattcgtatc aaagaaaatc agttagtaaa
    16681 gaaggtcgat ggtatggcat catataatag aacaagaagg atagcagaag aaataagaaa
    16741 agtcgtaagc actatgctta taaatggagt aaaagaccct agaataacat ctatggtgag
    16801 tgtaactgat gtagaagtta caaatgacct aagatatgct tatgtatatg taagcattct
    16861 aggtggagat gaagaatcca cactaacagg tcttaaaagt gctggaggat atataagaag
    16921 agaagtagga aaaaatataa aacttagata tattcctgaa atagtattta aacttgatga
    16981 ttcaatagaa aaaggaatgt atatggatag ccttataaaa agagttaatg aaaaaaatgc
    17041 tcaacaaaat gaggatgaaa attatgatga ataatatgga tagtattata aactatattt
    17101 atgagggtga ctattttata gttacctctc atatcagtcc agatggagac aatattggtt
    17161 ctacactttc aatgtattat acattgaaga atttaggaaa aaatgtatat tatgtacttg
    17221 atgatgaagc tccattaaat ttaaggtttt tggttgaaga tgtaaaaatc tataagtcta
    17281 atgaatttaa tatgaagaac tattctctaa ttgcacttga ttgtggggat aagatgagaa
    17341 tatgtgtgag tgatgaaatc aaaaataatg catcaaaatt aatctgtatt gaccatcatg
    17401 ctagtaatga ttcatatgga gatttaaatt atgtagatat tgatgcatct tctacatgtg
    17461 aattagttta taatttatta gttagatttc agcaaataaa agatattaat attataaatg
    17521 aagatatagc aacatgttta tatacaggtc ttgtaactga tactggaaac ttttcgtatt
    17581 caaatgtaca tgcaagtagc tttgaaatgg caaaaaattt acttgtttta ggtgcacaaa
    17641 aaaatactat aatacaaaat atatatcaaa gcaattcttc tggttattac aaattattag
    17701 gagaagctct aaagggtttg gagatatttg attcaaaggt atctagtata gttttaactc
    17761 aagacatgat gaatagaaat aatattagct ttaatgatgt tgatggaata acaacatata
    17821 caagagacat aaaaggtata gaagttggaa ttttatttaa agagaaaaaa caaaatgaaa
    17881 ttaaagtgag ttttaggtca aaaaattatg ttgatgtaag tgaaatagcc aagttatttg
    17941 gtggtggtgg tcatgtaagg gctgctggat gtactattag agatagtatt gataatgcaa
    18001 agaaaatggt actagaggca gtgttaaaat caatttaagg tgacagtaaa atgaataaga
    18061 ttataagtat attgaaaccc acaggtatga catctcatga tgttgtaagt agagtgagaa
    18121 agattttaaa tataaaaaaa gttggtcata caggtactct tgacccagat gcttcaggtg
    18181 ttttaccaat ctgtataggg aaagctacaa aagtatgtga agttatttta aacaaagata
    18241 aatcgtatat atgtgagctt actttaggta taagtacaga tacttatgat gcttcaggtg
    18301 aaattttaaa aaaagttgat gattttaaat ttagtaatga agacatagaa agagcttttg
    18361 acacacaaag aggagagata aatcaacttc ctccaattta ttcagcttta aaggtaaatg
    18421 gaaagagaat gtgtgattta gtaagaagtg gtagacaatc tgaaattact ttaaaaacaa
    18481 gaagagtaaa tataaaagac ataaaaatac taagtataaa aggtaataaa gtaatgtttt
    18541 atgttgagtg ttctaaaggg acttatgtga gaagtatttg ccatgatata ggagaatatc
    18601 taggttgtgg agctcatatg tcgtttttga atagaacatc ttctggtaaa tttgacttag
    18661 ataattcaat aacattagaa gaattagaat tattttatga aaataaaact ttagacaaat
    18721 acttatatga tatagattat gtccttgatt cgtttaatta tgttgtatta aaccctaatg
    18781 ctataaaata ttatagtaat ggtggctcaa tagatgataa aaggttttta aagaataatt
    18841 tcgataaaga tgatgaattt gtaagagtat acagtacaga taatttctta ggattaggaa
    18901 agttatcaaa acacaataat acaataagtg ttaaaagtga taagatgttc atataaccaa
    18961 tgtatttaaa aaaacaacaa aagagatagt actataataa cttctatagt ctatctcttt
    19021 tacttatgct ataatagttt gtgaataagt taagagtaaa ttatatttta gcggggaaca
    19081 tttattatgg tgattataaa atctataaaa gaaatagcaa acataaaaga aagtgtcatt
    19141 accataggaa attttgatgg tgtacacaaa ggacatcaag ttcttatagg aaaaacagtt
    19201 gaacatgcaa aaaaagaaaa tatacagagt attgtattta catttgcaaa tcatcctgta
    19261 aattacttta gaccaaactc aacaaaaaat attataagca atgatgataa aataaaatta
    19321 ttagaagatt tgggaataga tatagttgta atcataccat ttgatgagta tatgactaaa
    19381 atacctgcaa aggatttcgt agatgagata ctagtaaaaa aattaaaagc taaaaagata
    19441 gtaattggac atgactttac atttgcaagg gcaaaagaag gcaatgttaa tctattaaaa
    19501 agcttagaac atgaatttgg ttttgaggta gaagtaataa aacccatcaa aatcaatgat
    19561 gtaagagtga gtagtactta tattagaagt ttagtatccc agggtgatat ggctaatgtc
    19621 aaggaatatt tgggtagaaa ttacaagtta gaaggttgtg ttatacattc taaacacctt
    19681 ggaagaacta taggattccc aacggcaaat attgacctta agaataatat gctcgttcca
    19741 aagagaggta tttatgcttc tattgtacat attggagatg agacttattt tggtgctaca
    19801 aatgtaggct ataacccaac agttaatgga aaaactttgt ctattgaaac aaatatttta
    19861 gagtttgata gagatattta tggggaaaat ataattgttg aatttttgga aagaataaga
    19921 gatgaaagaa agtttaattc aatagatgac ttaaaaaatc aattgtataa tgatacaaat
    19981 tatgtgtatg aaaactatgt ttgcaaaaac aagtaatgta tgataaaatg attaaggaaa
    20041 ataaccatta ctcggcattt gaatactcca atcaatgctt agtaataggc gtttctaaaa
    20101 aaatacggag gtaatctaaa tgataaacaa atcagaaata ataaaagaat atggaagagc
    20161 tgaaggggat actggttctc cagaagtaca aatagcttta ttaacagcta gaataaacga
    20221 gttaaatgga catttaaaaa ctcataagaa agaccaccat tcaagaagag gactattaaa
    20281 aatggttggt agaagaagaa acttattagc ttacttaaag gaaaaagatc ttgaaggata
    20341 tagagcatta atagctaaat taggattaag aaagtaattt cattctttat aaaaaagcag
    20401 gtatagtgta tacctgcttt tttatagtta attcattata aagtaaaata gttaataata
    20461 aaagtagttt atatgttata aaaaattata aaatgaataa tattgggtaa gaatattaaa
    20521 atagtataca aatacataat caatttaaaa ggaaagacag gataaatata gaaattttat
    20581 aacaggataa ttagttggaa taaggaggat attattttga aaataaagtt agtatgcgat
    20641 agtttgtgcg atattccaga tgaaatatcg gaaaaagatt atatagagat agttccactt
    20701 acagttattt ttaatgatag ggaatatata gaaggagtag atataaagaa agaagagttt
    20761 tataaaaaag taaaagaaat caagcaaata cctaaaactt cacaagctac atatatggag
    20821 tttaaagaag tgtttgataa gttcataaca gaaggttatc atataatctg tatgacaggg
    20881 gctgcaaacg catcaggaac ttttcaaagt gctatgatag ctaaaaatga tgtaaatgaa
    20941 aatgaaaaaa tacatatatt tgatactaga aatttatctc taggtagtgg acaatatgtt
    21001 ataaaggcat gtgaacttct tgaagaagga ctgggatttg aagaaattat agatgaatta
    21061 gaaaatactc gcagtagtgt aagattgctt tttgcaccat atacacttga ttttttaaag
    21121 cagagtggaa gagttccagt tgcaactgct ttgataggaa atatgttaaa tataaagcct
    21181 atatttttct ttgataatgg ggaagctaag ttggtaaata aggttagagg aataaagaat
    21241 atagcaagta aattggtcga tataatttta gaaatgaatg aagggtcttt agaaggaaaa
    21301 atcgtcacaa taggttgtgg agataattta cacgattgtg aaatattaaa agatgaagta
    21361 aataaaagaa taaaagcaag aagagtatta tttactcgag gaggagtttc tatttgctct
    21421 catacaggac cagatatatt ggctataagt tgttctaatt agtagtaata taaggttttt
    21481 gcatatatat gtgaagataa ttttatattg ttaatttata gtatttttga taatatagta
    21541 aatagagtga tatacgtgtt ttttaataag aggaggacaa gcattaatgt ttgaacataa
    21601 aatatttaaa atggattttg caggaagaga actttctgta gaaataggaa agatttgtga
    21661 aatggctagt ggtagttgta tagttcgata cagtgatagt atggtaatgg taaatacaac
    21721 taaatcagcc aaacctagag acggaataga cttttttcct ttaagtgtgg attatgaaga
    21781 aaaattatac tctgtaggta agatacctgg aggtttttta aagagagaag gcaagccttc
    21841 agagaaagct atacttacat caagattgat agatagacca ataagacctt tattcccaaa
    21901 aggatttaga aatgatgttc aggtagttgc aacagttcta tcagtagacc aagattgtac
    21961 accagatata gtagcaatga taggttcttc aatagccctt tctatatcag acataccatt
    22021 taatggacca acaggttcag tatgtgttgg ccttgtagat ggtgcatttg ttgtaaatcc
    22081 aaacgcagag caaagagaaa aaagttcaat gcatctagtt gtttcaggta caaaggaagc
    22141 aataatgatg gttgaagccg gagctgatga agttccagat gaggtaatgc ttgatgctat
    22201 tttatttgct caccaagaaa taaaaaaaat agttgagttt atagaaggta tagttgcaga
    22261 agttggaaaa gaaaaaatgc ctgttgaatt ataccatgca ggagaagaaa taactcaatt
    22321 ggttcgcgaa tttgcaactg ataagatgaa aaaagcagtt cagacttttg aaaagttaga
    22381 gagaatggaa aatatggata gagttaaaga agaaacttta gctcactttg aagaaacttt
    22441 agaagatttt gaagattttg ttggagatat agaagaagta ttacaagata taataaaaga
    22501 agaagtaaga aaacttatag tacatgaaaa tgtaagacca gataatagaa aacttgaaga
    22561 aataagacct atatggtgtg aaactggcat gatacctaga gctcatggtt cagccatatt
    22621 tactagagga caaactcaag tacttaatgt tgctacttta ggtgctttag gagatgttca
    22681 aaaactagat gggttagatg aagaagaaaa caagagatat atgcatcatt ataatttccc
    22741 tgcatatagt gttggagaag ctagaccatc aagaggtcca ggaagaagag aaataggaca
    22801 tggtgcttta gcagaaagag ctttattacc agtaatacca tctcaagaag aatttcctta
    22861 tgctattaga ttagtttctg aagtattaag ttcaaatggt tctacatctc aagcaagtgt
    22921 atgtggttca acattatctt tacttgatgc aggtgtacct ataaaagata tggttgcagg
    22981 tatagcaatg ggacttataa agcatgatgg taaggttgca gtgctttcag atatacaagg
    23041 tatggaagac catttaggcg atatggactt taaagtagct ggaacagagt atggtataac
    23101 agcaatacaa atggatataa aaattgatgg tatagataaa gaaattctac aacgtgcttt
    23161 aaaacaagct aaagagggta gaatccatat actaggagag atgagaaaaa ctatatctca
    23221 gccaaaacca gaactttcac catatgcacc taagattgtt aaaatgcaaa taaatcctga
    23281 caagataaaa gatgtaatag gacctggtgg aaagataata actaagataa tagacgaaac
    23341 tggagttaag atagatattg aacaaactgg ggaagtattt atatcaggta ttgagattga
    23401 tatgattaag aaagctcaag aacttataaa taatatagta gttgaaccag aagtaggaaa
    23461 aacttataaa ggtaaggtaa gtagaataat gaactttgga gcatttgttg agatacttcc
    23521 aggaaaagaa ggattacttc atatatctca tatagctcat gaaagagttg ccaaagttga
    23581 agatgtattg aatatagggg atgaagttga agttaaagtt acagagattg atgaaaaagg
    23641 aagagttaat ttatcaagaa aagttctttt accaaaacca gaacataaaa ataaataact
    23701 tattatataa ttaaaagcaa agtcttagga ttttgctttt ttaaatacaa aaaagtagat
    23761 aattttaaaa tgatagttat ggatggctta tagttctttt tctgtcagtc tttactctta
    23821 taaagaagct atttaaaagc tgattaatag aaagctttat tgatatatat agaatcactt
    23881 aagttatatt tagtgcataa acagagctta tttttaatag tattaaataa gaaacaattt
    23941 gtacataatt agggggagtt ttaatgataa tgatggtact taataagagt aagctcaaaa
    24001 aaatcataat actaatttta gtagtgttat tagtattatc aggaggggta atggtattaa
    24061 agttatttaa caacaagcca gtatttaatt tatttaatgg tgtagattta ccatatgaaa
    24121 gaggtacaaa ggataaaagt ggatatgttg cattaacctg taatatagac cttggatggg
    24181 aaacagagta cgtagaatcc attttagaaa cacttaaaaa agaaaatgta aagattacat
    24241 ttaatgtaac tggaaaatgg gcagaaaaga ataaggatga attattaaag ataaaaaaac
    24301 aaggacatga aataggtaat catggatata aacatttaga ttattctaca ttatcatatg
    24361 aagacaatta tgagcaaata gagacctcta aaaagataat tgaagaaatt ataggtgaaa
    24421 aaactaaatt ttttcaagca ccagcaggtt cctttggtcc agaaacagta aaggctgcta
    24481 aagcattagg gtatacttct atcaaatggg atgccgatac tatagattgg aaatacaaag
    24541 accaaccaga ggtaatcatt gatagaatga agaaaaaaga cattaaagat agtagtataa
    24601 tcttaatgca tccaaccaac gcaacgacaa aatgtataga tgatattata gctattgtaa
    24661 gagaaaaagg actaaaagca ggaaaactta gtgatgtatt taagtagaca aagtataaat
    24721 atttggttaa gattgtataa gttgtagttg aattaattaa aagactgact tataatgtaa
    24781 tacatataaa aaataaatat aattaaaaca tagtgttttc aataatccaa tatgaaacaa
    24841 agaataaatt gttaggagaa tgtaatgtat aagacaaaaa tactggaaaa tgggcttaca
    24901 ataattggtg aagaaatacc atatctaaag tcaataacat taggtatttg gataaatgca
    24961 ggctctagga tagaagaagc acaggtgagt ggaacttctc attttataga gcatatgatg
    25021 tttaaaggaa ccaaaaacag aacatcaaaa gagattgcta gttcaataga taatttgggt
    25081 ggtcaaataa atgcatttac aagtaaagaa tgtacatgtt attatgtaaa actaatagat
    25141 gagcatatag atacaggaat tgatgtattg agtgatatga tactaaattc taaatttgat
    25201 aaaaatgata tagataagga aagacttata atattggaag aacttaagat gtatgaagac
    25261 tctccagatg acttatctta tgatttatta gtggaaaata tatatgctaa tgatggatta
    25321 ggaatgaata taattgggac aaaagaatct ctatacaata taactagaga atccatgtta
    25381 gaatacttaa ataagtatta tattccaaat aacgctgtta tttctatagc tggaaacttt
    25441 aactttgatg atatggtgga gaaaatcaaa tcaaaatttg gacactggga aaagaaaaat
    25501 ttgagtatag acataagtga ggctaagttt aatccttgct ttatatcaaa aaataaagat
    25561 actgaacagg tgaacttagc tatgtgccta aaaggtattc cttttgaaaa tgatgaagaa
    25621 gtctattcaa tggcagtggt aaataatatt ttcggtggaa gtataagctc aaggcttttt
    25681 cagaaaataa gggaagaaaa aggtttagta tattcaatat actcatcaca gacattatat
    25741 aggaaatgtg gtgaattagg tatatttgca agcatgagta cagaaaattt acaagatgta
    25801 tataatttaa taaagaaaga aattgaaaat ataagagaaa actatcttac agaaaaagaa
    25861 atatctgaaa gcaaggaaca gttaaaagga aattatatat tggatttaga aagtactagc
    25921 agtagaatga tgtctactgg taaatctatg ttacttagta aaaaagtaaa aactacagat
    25981 gaaatacttg aatgtataaa tagtgttaat attaattcaa taaagaaggt tgttgataag
    26041 gtattcaata tcgaaaatat tggtacatgt atagttggaa gagatgtaga aaagattcta
    26101 cacttggatt aatattgaaa aaagtaaatc tctggaggta taaaatatga atttatctga
    26161 aatagcaggt aaggaaatag ttaacttggt cacaggagaa agattggggg tcattggaga
    26221 atgtgacctt atactagatg aaactacagg cggtatatta gcgcttctaa ttccaaaaga
    26281 aaaaggattt tttgccagaa gaaaagataa gtcattttta gaagtaccat ggagaaatgt
    26341 aaaaaaaata ggtaatgaca tgataattat agaatatgag ggatatattt aggaggaaaa
    26401 aatgagtatt ttagtgcaaa agtttggtgg gacatcagta gaatcatatg aaaaaatgaa
    26461 tgaagtatgt aagatagtaa aagcatacaa aaaaaatgat gaagaattac aattagtatt
    26521 agtagtttca gcaatgggaa gaaaaggagc tccatatgct acagatacac ttataaattt
    26581 gtgtagtgca gtaaatgatg agccaagtaa aagagaactt gatttaataa tgtcttgtgg
    26641 agaaataata tcaggaacaa ttcttgctaa tttattgaat gcacagggga tagattctgt
    26701 tttctttact ggtcagcaag caggtataat tacaagtgat gaatattcta atgcaaagat
    26761 aaagtatata aatcctaaaa aggtaaaaag agctttagat gatggtaagg ttgtagttat
    26821 agctgggttc cagggtgtaa cagatgatgg agaaataact actcttggaa gaggcggaag
    26881 cgatacatca gcagttgcta ttggtaaagc tttagaatgt gaaacagttg aaatttacac
    26941 tgatgtggat ggtataatga ctgcagaccc tagagtagaa ccaaacgcta aagtattgag
    27001 ttttatagac tatgaggaag tattccaaat ggctgacaaa ggtgcaaaag taatacatcc
    27061 aagagcagta cagttggcta aaagtggaaa tataacttta gccataaaga atacaatgaa
    27121 tccaactttt gaaggtacaa aaataggttc tttatgtaga cacttagaag acaatataga
    27181 atatgaacaa gaaagagatt ttaaggttgc tgttgcaaat aaagatagcg tagcacaagt
    27241 taagattaag tcagcagaag aagtgtttac agaagtatta aatgagatag aaaagaaact
    27301 tataactata gatatgataa atttctttat atcagaaaaa gcatttgttg tagaagatgc
    27361 tgatataaaa tcattaaagg aaatactaga taaatttgaa ttagattatg aagtaaatag
    27421 agactgtgct aaggtaacat tgatatgttc aagaattgct gatgaaatgt ctggtatcat
    27481 gtcaaaggta gttagaggat tatcaaaagc aggggtatcc cttttacaaa catcagactc
    27541 aaatatgact atatcttgtt tagttagtga agaagatatg catacagcag tacatgctat
    27601 acatcaacaa ttttatttaa aataaactgt ataatacaat tattttttaa tcaaatttaa
    27661 gaatttcata tatatcttaa tatatttgat ttatttggta aaactaaatt aaatataatt
    27721 ttgataggag tttttttatg aaagattata gagaagataa tgaaagattt gataaagata
    27781 attgtagtga agaatctagt tgcgaagaga gagaatgtat aaagcaattt ggtaccaatg
    27841 aaatgccacc tcaacctcct aaagatattc aatgtataac tataattgga gaaattgagg
    27901 gacattttat aggaaatcct caaaaaaaag ctacaaagta cgagcatata attccaatgc
    27961 tatactcaat tgaggaaagt aatgatgtta aaggagtgtt agttgtttta aacactgttg
    28021 gaggagatat tgaagcaggt ttagctattg cagaactttt aaacagtaca tctaaaaaag
    28081 tagttactct tgttctagga ggaagtcata gtataggtgt tcctcttgct acagcaggag
    28141 attactcatt tatagcacca acagcaacca tgattataca tccagtgcga actactggtc
    28201 ttgtgattgg gataaatgag acttttgagt attttaaaaa gatgcaagat agaataattc
    28261 aatttataat aagaacatca aatatcaaaa aagatgtact tgaaaaactt atgcatgaaa
    28321 aagatgaact tgtaagtgat gttggtagtg tattaatagg aaaagaagct gtggattatg
    28381 gtcttataga tgaagttgga ggactaaaag aagcacttaa aaaattaaga gagcttataa
    28441 aagaatctga ggaagaaaaa aataatgatt aaaatttgtt taaataataa aatttatgat
    28501 ataatgatgt aataaagtag gagtgttagt gttaaggcat tagcactttt tgctgtgaag
    28561 gggtaaaact tgctaaaaat aaggagtgat attaatggcc acgaaaaaga agaaaaaaaa
    28621 gaaggtaaat accttaagtt ttaatgcaga atatcataat ttaataacaa tatttatagg
    28681 tgtattttta ttatatagtt taaattctaa ttctatggga tggatacctg tgttaatgca
    28741 aaatcttttt aagggactat ttggagggct ttcaatagca ataccattta tagtaattat
    28801 aacaggactt ttaggatttt ttgatggaaa tgaatatata tataggctaa gaaagactaa
    28861 actatactac ataattattt tatttatatt tgtattttat ggattattaa atgcaggaac
    28921 tcttcctgta gatagcccac taaaaggtaa catgtttgat gatgttatga aattgggtgt
    28981 aagtggacaa ggtagtggtt tgatagcaac aactattgcg tattatatga gtaaaatatt
    29041 tggtatagca ggtggatggt taataagtat cttcgcactt atactttctg taatgtttat
    29101 atttaatatt tctataaaag atttggtgtc aaatgcaaaa tcaaaatcta aagcatctaa
    29161 agacagcaat ttaacgttta aagataaaat tgcaaatatg aaaaaatctg caatagatat
    29221 gatgactgat gaagtagatg atactactat aaataaaaaa ccaggtttct ttaaagggtt
    29281 aatgtcaaaa ggtcttaata atgatgatga agaagatgaa tattttgaag aagaaaatag
    29341 tgatggtgta gatgataaaa ctataaaaat agttggattt aataaggcag aagatgagta
    29401 tttagaaata ttagaaggaa ctcaaagtat gccagagtta gatgttttaa aagaattaca
    29461 aaaagctacc aatgaaaatc cagttgtaga tactaaacca gaaaaaaaag ttgatatagc
    29521 taaacctaat ttaaatatag aaaaaactca acctatgagt attgtagcag agccagttaa
    29581 tgaggattat tcaaactata aaaagcctag cattgagctt ttaaataaag taaataagaa
    29641 gtctgatgaa aatggtaaaa agaaagtgtt gaaaaatgct tctcttttag aaaagacact
    29701 atcagatttt ggagtggaag caaaaattaa tcaagttaca gttggaccta ctataacaag
    29761 atatgaaata caaccaagtc caggagtcaa ggtaagtaaa attgtaaatt taactgatga
    29821 tatagcttta agtttagcag ctaaaagtat aagaattgaa gccccaattc ctggtaaaag
    29881 tgcaattgga atagaagttc caaatgaaga agctcaaatg gttggtgtga gagaagttct
    29941 agaaagtgaa gaatttaata attttaactc tcctcttgca atgggacttg gaaaagacgt
    30001 agcaggaaaa attataattg gagatatagg taagatgcca cacttactaa tagctggttc
    30061 tacaggttca ggaaagagtg tgtgtgtaaa tacattaata agtagtattt tatataaggc
    30121 aaatcctgat gaagtaaaat tactattaat agacccaaaa gtagttgaac ttgcaaatta
    30181 taatggaata ccacatctat tgataccagt agttactgac cctaaaaaag ctgcaaatgc
    30241 tttaaattgg gcagttacag agatgaatag aaggtacaaa ttatttgcag atgctcaagt
    30301 aaaagatgta acaagttata atgagaaagc ggaagaaaaa cttcctaaaa tagtaataat
    30361 aatagatgag ttagcagatt taatgatggc aagtgcaaat gatgtagaag attatatttg
    30421 tagattagct caaatggcaa gagctgctgg aatgcacttg attgtagcaa ctcaaagacc
    30481 atctgttgac gttataacag gggtaataaa ggctaatata ccatctagaa tagcatttgc
    30541 agtatcatct caaactgatt caagaacaat ccttgatatg ggtggtgcag agaagcttct
    30601 aggtaaaggt gatatgttat tctatccact tggtgcagca aaaccagtta gacttcaagg
    30661 ggcattcata tcagagagtg agtcggaaaa agtaatcgat tttgtaaaaa gtcaagttaa
    30721 agatggaata aaatatgaag aagatataat tgaaactata tctaaggtta atacttcaaa
    30781 gggtagtgat gaggatgagt ttttgagtga agcgatagaa tttgtcgtgg aaagtggtca
    30841 agcatctgcc tctatgctac agagaagatt taaaatagga ttcaatagag cagctagact
    30901 tatagattct atggaagaaa gaggaataat tggagcaagt gagggaagta aaccgagaaa
    30961 ggtattaata agcaaacagg atttgcagaa tttagaaggt gaatagaatt gtcagttata
    31021 aaaatagaaa aagcacttaa gctagataaa gtaatatttg tagatgtgag aactgaagga
    31081 gaatatgaag aagaccatat attgaatgca atcaatatgc ctctttttaa aaataatgaa
    31141 cataatgacg ttggaacaat ttataagatg cagggaaaac atgaagcaat acaaaaaggg
    31201 tttgactatg tatcgtataa attaaaggat atatatttac aagcagcaga acttgcatta
    31261 aattatgata atattgtcat atattgtgca agaggcggaa tgagaagtgg cagtatagta
    31321 aatttattat catcattagg tgtaaatgta tatcaacttg aaggtggata taaggcttat
    31381 agaaattttg tattagagta tctaaggcat gtaatggata caaaaaactt tgtatctgtt
    31441 catggattga ctggtacagg aaagactgat ttgttacatt tattagatga aaaaggaata
    31501 gatgtactgg atttagaagg catagctaaa aacagtggtt ctacctttgg ttttataact
    31561 tttgataaaa agccaccttc tcaaaagaac tttgaaacaa aactatttga aagtatattt
    31621 ttttcgaaag agaattatat atttgtcgag agtgaaagca aacgagttgg aagtgttaca
    31681 gttccaaatg aaattttcga ggcaatgaca cgagaaggac atcatatatt attagaatgt
    31741 gatattgaaa atagagttga tagactttgt agagattata tttatgataa agatgaaggt
    31801 aatatattga ttttaaaaga atgtataaac aagtttagaa aaagattggg taataaagta
    31861 gtagatgatt atattgattt attagaatca ggtgaatata aagaacttgt aaaaagatat
    31921 cttttagaat actacgaccc actttatatg cattcagtag aaaaatataa gtatagtaag
    31981 attataaatt ttaatgatac acaaaaagct ttagaagatg ttatagactt atatgagagt
    32041 atattggaag gagaaagtga atgttaaaaa tagcattaga atcattagga tgctcaaaaa
    32101 atttagtaga tgcagaaata atgatgggaa ttttaaataa caaaggctat aaattaattg
    32161 gagattttga agaagctgat gtaattatag taaatacatg tggatttata gagtcagcta
    32221 aacaagaatc tatagatacg ataataaact ttgcagagtt aaaaaaaact ggcaatttaa
    32281 agttgttgat agtaacaggg tgtctagccc aaagatattc tgaagaatta aaaactgaaa
    32341 ttcctgaaat agatgctata gtaggaacag gaagctatca aaatatagat aaaatactta
    32401 aagaattaag tgaaatgcat aaaattgtaa gccttaatga tatagagttt gtatttaatg
    32461 aagatttacc aagatatata tctacaccta gctatatggc ctatttaaaa attggagaag
    32521 gatgttccaa taattgtact tattgtataa taccaaaact aagaggtaaa tatagaagta
    32581 gaaaatttga agatataatt aaagaagcta agaaattagc tgaatctgga gtaaaagaac
    32641 ttgtggttat agcacaggat acgacaaagt acggttttga tttatatgga aaagaaagat
    32701 tatcagaact tttagaagaa cttgcaaaaa tagatggatt taagtggata agggttatgt
    32761 attcatatcc agaatctata acagaagaat tgatacaagt tataaagaaa tatgataata
    32821 tatgtagtta ctttgatatg ccaatacagc atgcaagtaa caatatttta aaattaatga
    32881 atagaaaaac tactaaagaa gatatattaa ataaaatcaa tctgataaga agtaatatac
    32941 cagatgctat acttagaact acaataatag tagggtttcc tggtgaaaca gaagatgact
    33001 tcaaacaact tgtggacttt gttgaagagg ttaaatttga tagacttggt gcatttgcat
    33061 attcaagaga agaagataca ccagcagata gattgccaaa ccatatagat gaagaagtaa
    33121 aaatacaaag aagagatact ttaatgatga ttcaacaaaa aatatctgaa gaacttaatg
    33181 acaaaaagat aggaaaaact tatgaggtgt taatagaaga acagatagaa gataatgtat
    33241 atacaggaag aacacaaggt gatgcagagg aaattgacag tatagtgtat gtaaaaagtg
    33301 tagacaatct tgaagtagga gaatttgtaa gtgttcaaat aaatgatgca atggaatacg
    33361 atttaatggg agatgtttta tatgaacttg cctaacaagt taactttgtt tagaatattt
    33421 ttaataccag tatttgtttt aattatgttg ctcaatatac caaataaatt tttaatagct
    33481 tgtattattt ttataatagc ttcaattact gatgctttag atggaaaaat agctagaaaa
    33541 tacaatctag tcactgactt tggaaaattt atggacccat tagcagataa gttattggtt
    33601 atttcagcac ttacatgtat gatagaagac catcttgtaa gtagttggat ggtaattata
    33661 atagtggcta gagagcttac agttagcata ttaagagcta tagctgctgc tgatggaaaa
    33721 gtaattgctg ctggaaacag tggaaaactt aaaacgataa ctcaaatggt atctatagtg
    33781 tttttattgt taggtgctca gtttgaaaat gtattgatat taaatattgg tgaaattctc
    33841 attcttatag ctacactact tacattatat tctggatggg aatatctata taaaaataaa
    33901 gagcttttta tgtcttctaa gtaaaaaatt atgctttaat aaataaaaac taatgattaa
    33961 taaataaaaa ataacaactt aaaattttaa aaatgtaaaa aagggtatac tattatagta
    34021 tacctctttt cattttaaga atattttctt ttgtgtatat aattattaat aatggtttat
    34081 aaataaaatg taatgaataa aaatataatc attagtagcg tttttaaatt gactaggttt
    34141 gatttatgtt atataattaa tatataacaa gagaacaaat gtttgtagat aaatgaaggg
    34201 atggtataga gatgagtgta gatcaagaaa aattaaaagc gttgaatgaa gctttaggta
    34261 aaattgaaaa agattttggt aaaggttcag taatgaaatt gggagaagca acatctatgt
    34321 ctatagatgt tatatcaaca ggagcgattg gtttagacat agctattggt ataggaggtc
    34381 tacctagagg gagaatagtt gaagtatatg gtccagaatc ttctggtaag actactgttg
    34441 cgcttagttg tgtagcatca gctcaaaaag atggaggaat agctgcattt atagatgcag
    34501 aacatgcact tgacccagta tatgcaaaag ctttgggtgt ggatgttgat aacctaataa
    34561 tatctcaacc agatacaggt gaacaggctt tagagatagc agaggcattg ataagaagtg
    34621 gagcgataga tataatagta atagactcag tagcagcatt agttccaaag gctgaaatag
    34681 atggagatat gggtgattct catgtaggtt tacaagctag acttatgtca caagcactta
    34741 gaaagttaac tggttcaatt aaaaaatcaa attgtgttgc tatatttata aaccagttaa
    34801 gagagaaagt aggaataatg tttggaaacc cagaaactac tactggagga cgtgcactaa
    34861 aattctattc atcagttaga ttggatgtta gaaaaataga tacaataaaa caaggtgata
    34921 aagttatagg tagtagaact agagttaaag ttgttaaaaa caaagtagca ccaccattta
    34981 agcaagctga atttgatata atgtatggag aagggatttc aaaaattgga gaccttttag
    35041 atatagctgc tgatgtagat atagttaaaa aatcaggttc atggtatagt tacaatgata
    35101 ctaaacttgg acaaggaaga gaaaatgtta aaaaattctt ggaagataat ttagatttaa
    35161 ctactgaaat agatgagaaa gttagagcat tttacaattt aaatgaagaa catgaagaat
    35221 caggtacttc agtatcaaaa gaaattgtag aagaataagt aaaaatacaa aaaaataact
    35281 agtaattaaa gacatgccac gctccctatt agcttgacac aatgttgaaa aaattataaa
    35341 attaagtgag gataaaatat ctaaatttaa ttttaattat taggaatatt ttttaatcat
    35401 agtgatgaca ttttgggatt attaacgaag gaggtggatg tcatagatag tgtagtaatg
    35461 attgtaatag gtgcagctgt tggtattata gctggatatt ttgttagaaa aaatatatct
    35521 gaagcaaaaa ttggacaagc tgaaaacttg gccaaagaaa taatagataa agcacaccac
    35581 gactcagaaa cagtacaaaa agaaaaatta ctagaagcta aagaagagat ccataagtgg
    35641 agaacagaag ctgaaagaga aaacagagaa agaagaacag aagtacaaaa gtatgaaaaa
    35701 agagtagtac aaaaagaaga agtcttagat agaaaattac aaaatttaga atctaaagaa
    35761 gtaaacctaa gtgaaaaatt aaaggtagtg gaaaagaaag aagaagaagt tgaagtaata
    35821 aaaactcaac agttagaaaa attagaaagt atatcaggaa ttacttctga taaggccaaa
    35881 gaaatcatct taaccaatgc ggagagagat gtaagacgtg aaatgtctat aatgataaaa
    35941 gagatagaaa gtcaagctaa agaagaagct gataagaaat caagagaaat tataggatat
    36001 gcaattcaaa aatgtgcagc agatcacgta gccgaaacta ctgtaacagt agtaagcttg
    36061 cctaatgatg aaatgaaagg tagaataata ggtagggaag gtagaaatat aaggacttta
    36121 gaaaccttaa caggtataga ccttataata gatgacactc cagaagccgt aattttatca
    36181 ggatttgatc caataagaag agaaattgca agaattgctc tagaaaaatt aatagcagat
    36241 ggaagaatac atccagctag aattgaagaa atggttgaaa aggcgagaaa agaagttgac
    36301 aatattataa aagaatatgg tgaacaagct gcatttgaaa ctagtgtaca tgggattcat
    36361 ccggaattaa taagattatt aggtagactt aactatagaa ctagttatgg acaaaatgta
    36421 cttaaacatt ctatagaagt tgctcatata gctggtataa tggctgctga aataggagca
    36481 gatattagat tggctaagag ggcaggttta ttacatgata taggtaaggc tgtagaccat
    36541 gaaatggaag gtacacatgt tgaaataggt atggatttac ttagacgtta taaagagtct
    36601 aaagaagtta tacatgccat gagtactcat catggagatt acgagcctca aacagtagag
    36661 gctgtattag ttacagcagc agatgcaata tcagctgcta gacctggtgc gagaagagaa
    36721 actttagaag catatataaa gagacttgaa aaattagaag aaatagctaa ttcatatgaa
    36781 ggtgtagaaa aatcatttgc tatacaagct ggtagagaaa taagaataat ggtaaaacca
    36841 gaagctataa atgatgaaga aatacatcta ttggctagag atatgactaa gaaaatagag
    36901 gatgaacttg aatatcctgg acaaataaaa gtaagcataa taagagaaac aagagctata
    36961 gagtatgcga agtaaaagaa ataatatcta aataataaga aaatattttt agaaatttaa
    37021 atttgccaca agatatgata atatatcttg tggcttttaa attgtttaag tttaatttta
    37081 tataatgcaa aaataatcta agtgctaaaa gtgctactta caaaagatta ataaaataaa
    37141 gctttatata tgtattattt atataattat ccaagtttgt ttgatataat gaagttgtaa
    37201 aataaatata ttactacttg gaatgcttgt acttaaataa gatgaaaata caatgacgct
    37261 aaagtgagga ttagagagag ggtacactat gaaaaaaaat acacttttac atacaaatat
    37321 tatggtttgc attattatta ctcttggttt tgtggctacc tctataattg gatatcaatc
    37381 taataccaat atttttaaaa atgatattga acatgtatct acattggctg ctgaaggtat
    37441 ttattatcag atagataaac tactttcaga acctataaat gtatctctta caatggcaaa
    37501 tgacagtcta ttaaaaaatt ttttagatgg tgagaaagaa catttaaatg atgaagaatt
    37561 tatttataaa ttacaagatt atctgaatgt gtatagaaat aaatattcat atgattctgt
    37621 ttttttagta tcaactaaaa ccaataatta ttatcatttt aatggacttg atagaaatct
    37681 tagcgctaat aactcagaga atcaatggta ttatactttc ttaaagaatg atgatgaata
    37741 ctcattaaat gttgataatg atgaagcaag taacaatagt attacagtct ttgtaaattg
    37801 taagataaaa gatgataatg gagcaactat gggaattata ggtgttgggt taaaggttaa
    37861 ttcattacaa atgttgctta aaggatataa tgacaaattt gatgttgttg cacgcttaat
    37921 tgatgataaa gggtttgtac aattagcagt agataaaacc ggtcatgaga atataaattt
    37981 ttttgaaaat tctagtagcg acttgtctaa ttcgaaacaa ttaatattaa acaacaaaaa
    38041 ggaacaaaag agtttttggt attcatctga aaaatcaaaa agttatattg tatgtcagta
    38101 catacctagt ttaaaatggc atcttgttct agaaaatgat tttactttaa tgattaaaca
    38161 gcttcatctg caatttttta aaggcattgc agttatagtt ttaattataa tatttgtact
    38221 ttttactatt acacatgtgc ttaaaaaata caaaaaccaa ataataaagc ttagtgtttc
    38281 acagaaattg gaatatcaaa aattgttgag caaatctact gaaggtcttt atgaaaatat
    38341 ttttgaaatt gatattacta acaataaagc tggttgtgaa gatgagaata ggtattttca
    38401 tgaatttgga ttagggctta ataccccata tgatgaagcc ttacatacaa tagctaaaaa
    38461 ccaaatcaaa gaagaatatg cacaaggtta tttagataca tttttacctg aaaatgtaat
    38521 taaacgttat aatagcggaa ttaataatat cagctatgat tttttaatta aaaaagatga
    38581 agaaagttat cattggatta gaattaatgc acgaattttc ttttggacat cagatgaatc
    38641 tgttcgtatg atatcttatc gtaaaaatat agatgaagaa aaaaatagag aattactact
    38701 tctcgaacgt tcacaacgtg attctcttac agggctttac aataaagcta caacagagga
    38761 atttattcgt tcatttttaa aaaatgaaag taatcaagat ttagaacacg tttttctaat
    38821 tttcgatatt gataatttta aaaatgtaaa tgataaatat ggtcatgtat ttggagactt
    38881 tgttataagt gaatttgcct tagaattaaa atctcaattt cgtgaggacg atattgtggg
    38941 acgtattggt ggagatgagt ttgtagtatt aataaaagac tttaataata ataactatgt
    39001 gcttatagac aaattagagc gtttttgttc taagattaat cagaaaaaat ttgttgagca
    39061 agcagaattt tctattgcat gtagtattgg tgtagcaatg tatcctgaac atggatatgt
    39121 atactctgaa ctatatgaga aagcagacca agcactttac tatgcaaaaa gccatgggaa
    39181 aaattcttat catatatttt cagaggattc tattgatagt atttcatttc atatagactc
    39241 tagagatata aaagtattat tagaaatggc tactgatggt gttgtcaaat ttgcttgtat
    39301 ggaaaactta aaattacttt atttcaacca aaaaatgctt gaatttactg gatattcagc
    39361 tcaaactgtt acttctatag gttttgatat tttttcgcct gtattacaag acgacttaca
    39421 aatggtacta gatacattaa gagaagcaat ttctaaaaga gagacttttg aaatagtttt
    39481 tcgtttttgt catacagatg gtcatatttt tcctgtaagg atgcaaggta agtttgtaag
    39541 tgaattatat caaaatcgtt atcctgtttt ttatgcgatt tatacagaca tatcaagtat
    39601 caatacttta ctagaaaata aatagtaaat actacagtaa aatctaaaaa taggatataa
    39661 tagtattaat ataagaagat tataaataaa acctgctaat gaaaatagat tatttttagc
    39721 aggtttttaa attttttata ataaatctta tttttggcta acaagattta ttttttttaa
    39781 gactttactt attattttaa gcattaatta tgaaatttat cattttatta tttacagaaa
    39841 gtattttata acaataaata tctatactta ttgcaaaatt tttttagcag ttttgtattt
    39901 atttgtattt attttgaatt tatttactaa atttgcctat aaaaagtata tataaaaata
    39961 tagttcaaaa tggtataatt aagtataaca gaaggaggta atgtaagtga gccaatacat
    40021 aaatataaat tctcagttag acgccctaaa attgaaggag ttcgagaaaa tattttacga
    40081 aaatatcaat gaggacgtta aagtagtgcc aaaagttact ccttttaaag gaataaatac
    40141 cgatttgttg tatgttaaag atggaagaat tttatttata aaatttatgg atacaacaga
    40201 agatatattt tttattttag aagaagagtt acttgaagtt atgaatgagg aatatgaact
    40261 tttgaaacta aaaatgggac aaaagaatag aaatataagt tataactacg tttacattat
    40321 gccatacgtt gaagttgagg aaacatatga atttgaagaa tttgttaata ataatataat
    40381 agataaaaat aagcttcaag atataatgaa taagggttcg ctggaggaat atcttaatga
    40441 tgagaatgat gaaataaact taaatttatt tttactagac atatgttcag aatactatat
    40501 aataaatgat aaacttcatc taaatgaaaa atttaaaaaa atttcattct acaatgatga
    40561 ctataagtat acagcaacta tgatggaaga cgttcaaatt aaagatgttg tttctattaa
    40621 atatgggaat acacttattg aaggtggttc tggtataggc aaaacagcaa ttatgctttc
    40681 tagggctata aaattagcaa aagtatatcc acatcataaa ttagtcatat ttacacatac
    40741 aaaacaactg tgcaatgagc ttcgagagag gatagagtta ttatacaaag ataataacaa
    40801 tttagaagtt cacacattta gttcttttat atttaaacta gctaaaaaat tcaatttaat
    40861 tgtagattat aacatgttaa aaaatgatta cgaaaagacc tttaataatc ttgtaaaaca
    40921 agcacagaac attataaaaa ataaaaatat gttcaaggct atttttattg atgaagcaga
    40981 aagcttttta gagtatgaaa tagattttat aagggagttt ttatataaaa caaaattcat
    41041 atttaatgtg tgttcttgta actccttgaa tatctctaat agattgaata tatttaaaaa
    41101 attatataat ggtatagaat ttgatgataa gattatctta agtaaaaatt atagacaagc
    41161 taaagagatt gtagatttta caaataaatt ttcaaataat tctaactcat atatcaacga
    41221 attaagacca aatacagaat ttagtacttt cttttatact aaagcactta gaggtggaaa
    41281 taagtctgtt gatataataa aagtaagtga ccttgatgac caaataagtt ctgtaatctg
    41341 ggaaattgag tatttaataa gtaaaaaagg tcttgattat tctgaagttg ctatcgttta
    41401 tccttacaat aagaagaaat taaaaagtgg aaaaaccatt tactttcaat atatgttaaa
    41461 aaaagcattg gaagaggcaa aaattcctta tatatgtgca gaagataatt tgacaaatat
    41521 aagtaagaag gtaggaacta caatagcaaa tatatatgca ataaagaatt tagagtataa
    41581 agcggtaata gtatgtgaat tagagatgtt atacaatcaa actataaatg atattgaaca
    41641 agattatcaa gtaaatgact ttgtaggaga tttaaataag gtttatttag ctatgagtag
    41701 agcaacagac tacctaagta tagtaacaac ttttaatgaa gaagcaagtg atataataag
    41761 acttattaca gaatcaaaag atatttagta aaaaaatatt tgtaatttaa gaaaataaaa
    41821 agagactgag atttgtaaaa taaactttac caattcagtc tcttattttt tagtctactt
    41881 tcccaatatt atcaagaggt aatagtctca ccataacctt accaagaact tcatcttcat
    41941 caaccatacc tacatcaggg aatctactat cattactatt ttctctatta tctcccattg
    42001 caaatagttt accttttgga acaacagtat ctatatctcc agaagtatag ttattgtgta
    42061 tatatggttc atttaataat tttccattta catacacttt agaatttgat atttttattc
    42121 tgtcaccttc agtagctata actcttttta ttaagtcttt tttctttcct gtttctccat
    42181 caactaaatt ggttttaaaa actacaatat cgcctttttc aggtttacca accttgtatg
    42241 atatcctatt taaaatcaga taatctttat catctaaagt aggatacatt gattctccac
    42301 ttacaataga aggtcttata aattgtagaa ttacaaatgc aagtacaata gccatagcta
    42361 ttgacttaat ccaatcaaat atttcttttt taacactcat aacttttctc cttatcattt
    42421 gttattaaat tagaatacat tataatagaa agaaataagc aagaaccact atacccaaga
    42481 ctattctata ataaccaaat actttgaagt catgtttttt gatatagtcc ataaaaaatt
    42541 taataactac aattgaaaca acaaatgcta ctacagaacc aacacctaaa ataagccatt
    42601 caaatccagt aaatccaaat ccagctttta gaagttttaa tgcactagct ccaagcattg
    42661 tagggatggc taagaagaat gaaaactctg ctgctacata tctagaagta ccaagtaata
    42721 ctgcacctat tatagtagaa ccagacctag atgtacctgg tataagagct agacactgga
    42781 ataatcctat acaaagagct aatttatatg taacttgaga aaaatcttta tacttaggtt
    42841 ttttatttct cttttcaagc cctatcatta ttataccata tacaataaga gcaatagcaa
    42901 ctactgttga attaaagaat aatctatcta tatcatcttc aaacagtatt ccaataactc
    42961 cagatggtat aactgcaatt ataaccttaa gccataaacg gactgtttct tttttctgct
    43021 taatattctt tgcgctatca aaaggattta attttctaaa aaatataaca agtacagcta
    43081 atattgaacc aaattgaatt acaactaaaa atgtacttat aaatgtattt gaaaaattca
    43141 attttataaa ctcatcaact aatatcatat gccctgtact acttactggt agccattctg
    43201 ttattccctg aactatgccc aaaatgactg ccttaaaaat ttcaagcaaa ctaaatgttt
    43261 ccaaatcaaa atacctccaa tacaaattta tagtagcata ttttattcat agattaataa
    43321 aaaaatgcca ccttttacta acttataata ccatagtact gtgtagtgca caatggaaga
    43381 ttgatatttt cataaaacct tcataatata acaaaataaa cttaaaagtt atctattgaa
    43441 taaggggtat atttgagggg gaaatatatg gtatagtaaa agtatagcta ttttatttta
    43501 tgaaaaggaa aggagttatt atgtatagta caaaaatact agatgattat gagtatgaaa
    43561 cttttaatgt tttttctaca aaattaaatc caaacacgaa acacgattat ttatcaaagg
    43621 ttatactgtt taaagaattt ttaaaaggga aagaattgat ttatgctacg aaagaagatt
    43681 gtaaaaattt tgtagactat atacagacta aatatgcgaa atcaacttgt gaaaagatat
    43741 atagttattt acatagtttt tataacttct taaaaaaaga aggatacata gatataaatc
    43801 catttagata tgtagaaaaa cccacagtaa caagaataaa aacaaaagat gatgttctaa
    43861 gtatacaaga aataaataaa cttataggta tcctaccaaa attaaatata agagatagag
    43921 taataatagt ctgtctagtt actactgggt gtttattaaa tgaattagtt agcttaaagt
    43981 ggaaagacct tatggtagat gaaaacgata actcatatgt aaggttaggt aagggaagaa
    44041 aagaaagagt agttaaatta catccatact tttttaaact tttagaagat tacaggaatt
    44101 attctgggct tccagaggta ataataccta gtgatgattt tatttttaca actcaaaaga
    44161 gtaattctat aacagataga aatgtcagac ttatagtcaa aaaagcatta gatttagctg
    44221 gactttctca atattcagca agagatttta gacattcatt tgcagcaata agtttaaggc
    44281 ttggggcaga tgaaagtgat gtaaaaaatc agcttggatg gagtgataaa tactatgcaa
    44341 ttagatataa gtatgtatta aattttgttg atagtgaaat agtggattac ttaattgaaa
    44401 aagataattt ggatataaat aaaaaatagt aataaataaa aaatactata tataaatgtg
    44461 aacaaaaaat aaaaaagtct tgttatagtt cgtaaaatta tatataatta tttatgtact
    44521 aatgtgtaca cagtaatcac acgacaaaag atttaaggaa ggtgctaata taatgataga
    44581 taataaatat actacttact caaacccact tacagacaga tattgtagca aggacatgag
    44641 ttatatattt tctccacaat ttaaattctc tacatggaga aggttatggg ttgcacttgc
    44701 agaaggtgaa catgagttag gaatcaatat aactgaagaa caattagatg agctaagagc
    44761 taatatagat aatataaatt ttgatgaagc tagaaaaata gaaaaagaag taagacatga
    44821 tgtaatgtct cacgtaaaag cttatggttt acaatgtgaa aaagccaaag gaataataca
    44881 tttaggagca acatctgcat atgttggaga taatacagat gttatacaaa tgaatgaagc
    44941 tttaaaactt ctaagagtaa agcttgtaaa tttaataaac aatttaaaag aatttgcact
    45001 taagtacaaa gatatgccag ctcttggatt tacacacttc caagctgctc aacttacaac
    45061 agtaggaaaa agagcttgtt tatgggctca agatttaatt cttgatttgg aagatttaaa
    45121 ctatagaata gacaacatga agttaagagg agttaaaggt actactggta ctcaagcaag
    45181 ttttttaagc ttatttgaag gagaccacga aaaagtaaaa gagttagata agaaaatttg
    45241 taaaaagatg ggataccatt cttcctatgc agtaagtgga cagacatata ctagaaagtt
    45301 agattatcaa gtaataagca tactatcagg gatagctcaa agtatgcata agatgactaa
    45361 tgatataaga cttttacaaa gtttaaaaga attagaagag ccatttgaaa aaaatcaaat
    45421 aggttcatca gcaatggctt ataagaggaa tccaatgaga agtgagagaa tagcatcttt
    45481 atctaagtat ataatctctg aatctataag ccctgcaatg gtacaagcca ctcaatggtt
    45541 agagagaaca ttagatgact cagccaataa gagattggca atacctcaag catttatggc
    45601 agcagatgct atacttgaaa tagggataaa tgtaactgat ggtttagtag tatatgaaaa
    45661 tatgataaat agacgtgtaa atgaagaact tccttttatg gctacagaaa caatacttat
    45721 ggaagctgta aaaagaggtg gagatagaca ggaattgcat gaaataataa gagaatattc
    45781 tatgaaagct gcctatagag taaagcatga aggcaaggat aataacttaa ttgaacttat
    45841 aatgaatgat gattcattta aaatgagcaa ggaagaaata ctatctataa tggacccaaa
    45901 aaactttata ggtagagctc cagaacaagt tgtagaattt gtaaatgaag ttgtagaacc
    45961 tgctataaaa gattataagg aagacttagg aaaagtagat gtagacctaa gagtatagaa
    46021 ttgtacagat aaaatataat taaaaacggc tatcttattt ataaataaga tagccatttt
    46081 aatgggctag cgtcttctct ccaccgctgt gaagagttct tctttactta ctataccatg
    46141 aatttaataa aatagctata taaataatat ttaataggaa taatataaat aaaaataaaa
    46201 aaatgataag attactaatt aaatttaaac attcagcaaa aactattgta cttgcaatat
    46261 ttttaatgta aactgaaata aagttattta gataatttaa taaattttaa aacaaccgag
    46321 gtgattatat gaactatata gtaaaagata ccataagttt tttagtaaaa acatttccta
    46381 agatttattc tagcctgtac ttagaagacc taaaaaaatt tgcaccagat tataatgtaa
    46441 ataaaacaca attaagagca ttagttttca taaaaaatta tggagtaata agtatgactg
    46501 atttatgctc taagttaaat atagaaaaag gcagtttaac tagtatggtt gatgatttaa
    46561 ctgataagaa gtatgtaaca aggaaaagag atttagttga tagaagaaaa tatctaattg
    46621 acattactga agagggagat aagatagcaa ctgattttat ggataaatta agtgatggtt
    46681 taggagaaaa actttctaaa ttaactgaag aagacagaaa aaaatattta gaagcaataa
    46741 atactcttca atatatatta aacaaagaag aatttagata gaaaaaatat aaaaattttt
    46801 gtatttaatg gtactaagat taattctttg ttattcattt aactatataa ttataagtct
    46861 aaatacaatc taaaaagtac atcttaaatt ttcttgatgt acttttttat aatttctcta
    46921 actaaggcaa gacaagtttt agatgcttta attaaagtga ataaagatta ctggccaaca
    46981 ctatataaag aaaatgaaaa atagtcaggt ctaagtctta attaatatat taattaagaa
    47041 atgtcccctt ttcaaataat atctgaaaag gggacatttt atatcattaa atttatataa
    47101 attaagttta aaaaattatt tttgtaaagc tacatattgc tctaaacctt cttttaataa
    47161 tgtagcagct ctatgaaggt ctttttcatt taagatgtaa gctaatctta tttcatcacg
    47221 tcctaaacct ggagtagcat agaatccttc agcagggcaa accataactg tttcattatc
    47281 tttattaaat tcttttaaca tccaaattgt gaaatcttct gcattttcaa ctggtaattt
    47341 agcaactata tagaaagcac cagttggttt tttacatata acaccttcaa ccttcattaa
    47401 ttcattgtat aatacatctc ttcttttttt gtactcttca ttaacttctt tgaagtaaga
    47461 aacaggagtt ttgtataact caacagctcc tatttgctct aatgtaggaa cacaaagtct
    47521 tccttgacat aatttaagta tttgagcgat aagaccttta tttttgcaag cgatagaacc
    47581 aattctagca ccacaagcac tgtatctctt agaaacactg tctattatta taactctatc
    47641 ctgtacaccc tctaagttac cacagcttgt atactcaagc ccatcataaa caaattctct
    47701 ataaacttcg tctgctatta tccataaatc tttttcttta gctatttcag ctaggatatt
    47761 aagttcttct tttgtataaa ttgcaccagt tggatttcct gggttagaaa gaattatagc
    47821 cttagtttta tcatctactt tagacaatat ttcttcttta gatggaaggt ggaaaccgtt
    47881 ttctgccttt gttgtaacag cattaacttc tacgtttaca gattgaccaa atccattgta
    47941 gtttgtatag aatggttctg gaactaatag attatctcct gggtcacaaa ctgccatcat
    48001 agtgaaaagt aaagcttcac taccaccgtt agttactaat aattcatctt tttcaaaatt
    48061 catatcgtaa gttttatagt aattttgaag tgcttctaat aattctggaa taccttctga
    48121 tgtagcatat tctaagactt cgctatcaaa gtttttaaca gcatcaaaaa atcctttagg
    48181 agtttttatg tctggttgtc ctatgtttaa gtgatatact ttgattcctt tatcttttgc
    48241 tgcttgtgca aatggaacaa gttttctgat tggagaggct tgcattgcac taactctgtt
    48301 tgaataattc attttaatac cccctattta atttaaatac gtatattgta ttatgtaaat
    48361 tgtatgtttg aatacaagac atctttacaa gataataata acatacttat gggtaaaaat
    48421 catcaaaaaa aattaatata gctttaaaat aaacttttaa caaattatag taaaataccc
    48481 atgtttatgc cactaaatta tgtattcata aattaattta tagtaagata atattctgat
    48541 gtactgatag tgatttttta gttataatct ttcagctata gacaaaatat ataataataa
    48601 atatgcaaaa ttataaaaaa tattataaat ttatttaaca gatacgataa atatcatata
    48661 attatattaa aggctattaa ctaagaggtg ttaattatga aagaattaag aatagatcca
    48721 attaccaatg atgttgttat atttgctaca gataggttaa aaagaccttt agatacagca
    48781 gatatcccaa atgaagatga agaaactaat gaatatgatg aagaatgccc attttgcaaa
    48841 ggaaatgaag ctcatgcaac tgatgcatta tttgaaatag atagtgaaga aggatggctt
    48901 gtaaaatctg tctacaataa atttcctata attgatgata tggcaagaga tgtatatggt
    48961 gttcatgaag taatgataga gagcgataaa cataatcgta gtttttataa catgagtcaa
    49021 aaagaatttg aagatgtttt ttttatgtat agaaatagat ttagagattt gtcgaaagat
    49081 gataaagtag agtatgttag tatcttcaaa aacttcttga gaaaggcagg agcatctttg
    49141 atgcatccac atgctcaaat attgtctatg tcttttattc cacctgaaat tacgaatgaa
    49201 ctgttggttt caaaggagta ttatgacagc aataaaagct ctttgtatga tgatttaata
    49261 gaaaatgaaa taagtttaga tagaagagtt gtttataatg gagaagcttt tttggtactt
    49321 ataccatatg caaccaagta tagtggagaa gtaagaataa tatttaaaga taaaatagag
    49381 tttggtgagt taaatgataa taatatacag gagctttcta caatatttga aaagttgttt
    49441 aagaagttat acaatatcaa tggatatatg ccatttaatt tatgtattca cactcatcca
    49501 acaaagattg aaacaaaatc gtattttaat gttcatatgc acataatccc aagaaaatat
    49561 aattttggag gatttgaact tggaacaaat atgtatgttt cttcaatgag ccctgaagat
    49621 ttaacaaaaa agttaaaaat tgattaaaac atatattttt aggtattaag taaatagtaa
    49681 ttttagatga aattatagta tagcattgtt aaaataaaag taaattaaga atttacaata
    49741 aaattgttga aaagccccca tctttagcta tggggagtgt gtcaatgttt agatgaggag
    49801 tataagtatg aaatttatat catggaatgt taatggaata agagcttgtg ttgggaaagg
    49861 atttttagac tttttcaaag aagtagatgc agatatattt tgtttacaag aaactaaatt
    49921 gcaagaaggg caaatagagt tagatttacc aggatatttt caatattgga attatgctga
    49981 gagaaagggt tattcaggta ctgctatatt tacaaaaaaa gagcctttaa aagtaatgta
    50041 tggaataaat atagaagaac atgacaaaga gggtagagtg ataactctag agtttgaaga
    50101 tttttacttt gttacagtat atacgccaaa ttctcaatct gaattaaaga gactagaata
    50161 tagaactaga tgggaagacg actttataga ttatttaacc aaactagata atcataagcc
    50221 tgtaattgtg tgtggagata tgaacgttgc acataaagaa atagatttaa aaaatcctaa
    50281 aaataatatg aaaaatgcag gttttactaa agaagaaaga gagaagtttt ctaaattatt
    50341 agacagtggg tttatagaca catatagata ttttaatcct gataaagaag gtgtttatag
    50401 ttggtggtcg tatagattta atgcaagaaa aaataatgca gggtggagaa tagattattt
    50461 ttgtgcatcc aaaaaattag aagatagatt agtaagtgcg gatatacaca ctgaaatatt
    50521 aggttcagac cattgtccag ttgaattaga gataaaataa aaattaatta tgataaaaat
    50581 tgggctgtag atataaattt aaagttaact agttttttaa tctacatgcc tattttttat
    50641 ctaaataaac tctatttgtt ttttctttgc ttaacatttt ctaatgtaaa ttgatttgtt
    50701 ttccacatat tataagctaa gttaatgatt tttttctcgt ctttagttaa ttcacgattt
    50761 aaaattttcc taaattcatc aaataactta tcataatcaa ctcttttttt gttagaatat
    50821 cttatagttt taggttttat actcgtataa agatatatat ctgggactat acttggattg
    50881 tatatcttaa taaaaacttt agcagtataa tatgcatcat ttaaagcatt gtgataagac
    50941 attttttcat caagttccaa tatagaaata gcattttgta ggccaatgct ttttcctgct
    51001 ggattattga aatatttaga tgcatgttgt tgtatattaa tataagattt aggtaaggaa
    51061 tttgatggta gcttgtgata gttgatattc ctgtataatt ccttcaaatc tccagctccc
    51121 caaacacata atatagggtc ttgtgatgat ataaatttta taaaattgtt gtagacctca
    51181 gggaaagtag gcgaatcatt aaaatcagaa cttttaatat tagtcatacg actaataaag
    51241 ggatgtatgt ctttataaat tgtaggtttt acatagctat taaacgtatc tattatattg
    51301 aatttagaat ccaatttaat tgctcctatt tgtataattt caaaaggaca cttttcattg
    51361 gatacagttt tattgagttt tttatcaaat ccttggttaa attccaaatc gaaaattatg
    51421 tattccataa agtttatctc ctaaattttt ttattatttc ttttactata g
//
LOCUS       DAEHWM010000020        47529 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.021, whole genome shotgun sequence.
ACCESSION   DAEHWM010000020 DAEHWM010000000
VERSION     DAEHWM010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 47529)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47529)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47529
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.021"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            316..2076
                     /locus_tag="KNP36_001186"
     CDS             316..2076
                     /locus_tag="KNP36_001186"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873074.1"
                     /translation="MDRFEVLKYLKFNVWHSEWPLELLKGAITKDNATGNLLLQLKMC
                     NISDKEIKSAYFTIECFNDAGDLIDNNLKYVYQDINIKPHECLGDDIAIKINDNKTRA
                     INIILEQVVFSDDKVHKYEREEGLIIPKLDKIELLNIELLEELKKDYEEYDFQYEIKY
                     MPNIIEKKAWSCCCGKINKLEKDKCDNCKRSKILQIKKINKNYLESIYKKSLKKKKEI
                     EIKLEKDNRHKLKNINKNNRRTSILLISILLIFIIFIGKNIINKHAFLDEIKYKNEYS
                     KKISVEKDNVYMLKNNGKVTHRKVNGESSSIPGWENIISIASYDNSIIGIKKDGTVVS
                     KGLGNSDSDNISKWRDIIDIECDSGTFIGLKKDGTVVATGNNDYGQCNVNNWFDVVSI
                     EITKSTIEYMKNTTVIGIKKDGKVLLTGYDSLNHRKETDKWRDISKIKCGSYGIFGIK
                     NNGTVVVSGSAYDIKNWKDIVDIHIGLCGIVGIKRDGTIISTDEKFNEIIKNWKDIIS
                     AEIIDNHEGISIVGINSNGDILTSSRGQNLDNIKRLEDVEYINFDDSIDNFLVGIRKD
                     NVIFIRGINNTINEEYNEEI"
     gene            2110..2466
                     /locus_tag="KNP36_001187"
     CDS             2110..2466
                     /locus_tag="KNP36_001187"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873075.1"
                     /translation="MKNYIARCLSNMGVLLAGIQVLAGIIIMCQKVEVPYDYLSDTYE
                     QYSPIMIGIGAGVIVSGIVICLVLKGLAELVENSADQTQYQKEILMLLKNNNVNEKIN
                     EVKIEQQFTNEELPKL"
     gene            2675..3388
                     /locus_tag="KNP36_001188"
     CDS             2675..3388
                     /locus_tag="KNP36_001188"
                     /inference="COORDINATES: protein
                     motif:HMM:NF012301.1,HMM:NF016296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873076.1"
                     /translation="MIITICENDDMQRDIIYDFVKIFLTKIKVKHYDILMFKNGEELL
                     EEYPNKVDLILMDINLGGRNGFDISKDIRKFDKDARIIFVTVSEKYAIKCYEINAFRY
                     MIKPIYYKEFEKYMLDFAIDWRKREAIITIKRKKQIIKIEEHNILFVEIVNRKLRVVT
                     KNEEHIINDKMDMFEEKLKEDIFFRCHKSYLINLLEVTNFNYNFVYLTSEKIKIKVAP
                     KKTKKLKEKLANFFREIIW"
     gene            complement(3852..4205)
                     /locus_tag="KNP36_001189"
     CDS             complement(3852..4205)
                     /locus_tag="KNP36_001189"
                     /inference="COORDINATES: protein motif:HMM:NF024252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873077.1"
                     /translation="MNENLKELRIKLGLSQKEFAEKLLVSDATISRLEKGERKLTDRF
                     IFQICEVFNVNEDWLRNGNGEMFKNIDDIELAAMMGKTFSSNDEFLKKVFLTFAELTD
                     DEREVIQKVIDKLSK"
     gene            4385..4555
                     /locus_tag="KNP36_001190"
     CDS             4385..4555
                     /locus_tag="KNP36_001190"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873078.1"
                     /translation="MYNNNDKKLINLFESFKKIDYTEQSLVYFLSLSFIVNRKCHKDA
                     NLYSRRGECNYE"
     gene            4548..5354
                     /locus_tag="KNP36_001191"
     CDS             4548..5354
                     /locus_tag="KNP36_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage antirepressor KilAC domain-containing
                     protein"
                     /protein_id="HBF0873079.1"
                     /translation="MNNLNIKGKQKFMDLEIPIIEGGFGEGKKCITDKTISEIHNMEI
                     KHVRELINRNIRRFINAIDFIDLKVVVDNDYNLEVLELLSYRKMQISKANNIYLLSER
                     GYSKLIKIMDTDLAWEIHDKIMDEYFNMREQLIDSYMIQDSIERAKRWIEEEKERLLL
                     KETIQVQQPKVEYHDKVLNPDKLVTTTDIAKDLGMTAQALNKLLHLNRIIYPERINGR
                     IKCWKPYKNYLWLIPEYADFKITEHDTQLKWTEIGRKWLIEFVENIKKIS"
     gene            5418..5642
                     /locus_tag="KNP36_001192"
     CDS             5418..5642
                     /locus_tag="KNP36_001192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873080.1"
                     /translation="MIKQILNKRGSLLNLASEYLTEQDYLKFQGWYTHRYSKLDAYDA
                     SINEYLNYKNDKKLITYVFNLKFQEALIEI"
     gene            5666..6202
                     /locus_tag="KNP36_001193"
     CDS             5666..6202
                     /locus_tag="KNP36_001193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873081.1"
                     /translation="MNYNYVTKIDLKYGNTQFGFEKYSDALDKYRELKEEFKYVPCII
                     KLHSYVAHQDLYVKEIKADGFEKKYLDIKNLIKLFKEHKQNISDELSLCDKKKEEVLH
                     VIEEMNLDTASLNDKIDTIKELKNTLVKRRLVKYELNKYFAFCNTLYEIEEELKKYES
                     KYKQKENQGKSRFKKNKK"
     gene            6211..6351
                     /locus_tag="KNP36_001194"
     CDS             6211..6351
                     /locus_tag="KNP36_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873082.1"
                     /translation="MEEYHFNLIKKLCAERKIHKGWFRNIEKCGCGGKCNKKNCKMLE
                     KL"
     gene            6362..6595
                     /locus_tag="KNP36_001195"
     CDS             6362..6595
                     /locus_tag="KNP36_001195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873083.1"
                     /translation="MENQIELTEKDIENTLSALNIIKYICIKSKHCKNCPLGYMKNLD
                     EHNCMLYELIDKGLLPCDWSVKKVTRLLDTTEE"
     gene            6614..7027
                     /locus_tag="KNP36_001196"
     CDS             6614..7027
                     /locus_tag="KNP36_001196"
                     /inference="COORDINATES: protein motif:HMM:NF021182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873084.1"
                     /translation="MELDFRIWNGFRMIHGEELRLLTEEMFIKSGYSEQYYNDICIPR
                     VEDLKIMQYIGLKNCFEKKIFQYDIVKFIFDGVWKVCLVNLSLPKGATVTFESIGGKY
                     TFNLSEIFSKDRKLEIIGNFYENKDVIKKYNLSIE"
     gene            7037..7231
                     /locus_tag="KNP36_001197"
     CDS             7037..7231
                     /locus_tag="KNP36_001197"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873085.1"
                     /translation="MDEMIIRVKMGEPLPTLGKIIKCTTCLTNEEKCFKVNKICKLSW
                     INDRNSEGLIVECKGKYIKY"
     gene            7438..7992
                     /locus_tag="KNP36_001198"
     CDS             7438..7992
                     /locus_tag="KNP36_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003479931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA 2'-phosphotransferase"
                     /protein_id="HBF0873086.1"
                     /translation="MSKKDKLSIFISLILRHKPETIGIKLDDYGYADVNELIEKINNT
                     GRNINIEILEQIVKEDNKQRYSFNDDRSKIRANQGHSINVEVELKELEPPKCLYHGTA
                     TRFLENIKKEGIIRQSRLYVHLSNDIDTAVKVGKRHGVPVVLKINTGKMYENGYKFYL
                     SENNIWLCKYIPFEYVEKISRVVK"
     gene            8019..8345
                     /locus_tag="KNP36_001199"
     CDS             8019..8345
                     /locus_tag="KNP36_001199"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873087.1"
                     /translation="MDFNFRKICEKDELTDDFIIKICQLSHEEFGGTIYVPCNIHPCG
                     WDELEVPNPKDLDSDKLMEEFLLEYKFECENISSNIYDSDHPFIGKTLREILMIVDCR
                     FIIGVI"
     gene            8360..9136
                     /locus_tag="KNP36_001200"
     CDS             8360..9136
                     /locus_tag="KNP36_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873088.1"
                     /translation="MENIELTPRDYFEDIKNKKQKNTNENLDIVYENSLILLNKYIVT
                     GQKKGAKKLMFLLECIEKERNVIELGIDTFVYKEDIEKYIDDISKNTVKIIELENYER
                     EIPDEIVEIIEKTKDIFDKMYVLFTDYTGKITKEISKERRDKDPILFGVFSDEKSRAI
                     VDRFYYLGDWEDEYCDLTLEKMINDYKKKGRQDILKHIITPKSLDELKKELDSLEKNN
                     DTYKQVANIKPLPTTKNSSVEPPKLNIFKKIKNRVFKNEK"
     gene            9126..9527
                     /locus_tag="KNP36_001201"
     CDS             9126..9527
                     /locus_tag="KNP36_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873089.1"
                     /translation="MKSNVDLTENRDFRDVRGRGINILGIEDAPNRMLSFSDFGIGRL
                     YGKNLEFEFNKNEVFLTGNANDREEKKFLILCEENKVCVRCGDELREGWDKVSIELCN
                     ECYEMLDVEYKNKKIIRELFFRDRDVNIELL"
     gene            9716..10036
                     /locus_tag="KNP36_001202"
     CDS             9716..10036
                     /locus_tag="KNP36_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873090.1"
                     /translation="MFIKSFRCIFRHKFSRIKDCQLITTRSQQYTCKIWMCKYCGQIV
                     AGSTPVYHPNMKVNEYCVKCEFSACANNYEGYCNSKDKEIEFKSICLKGNKEILQCKN
                     FDLE"
     gene            10067..10252
                     /locus_tag="KNP36_001203"
     CDS             10067..10252
                     /locus_tag="KNP36_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873091.1"
                     /translation="MKINVHVKTNKIGSDCELEFEIDDDDLKDMSDEEREGYIDKIAW
                     DYVFENFIDWNWYEVED"
     gene            10307..10708
                     /locus_tag="KNP36_001204"
     CDS             10307..10708
                     /locus_tag="KNP36_001204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA ligase"
                     /protein_id="HBF0873092.1"
                     /translation="MKELLEVKKIFDSLASTSSRKEKERILEKYKNNRMFVECLQFLL
                     DSNILTGISKNKICKNLNNTGHNELENIYDMLDYLIKNNTGRNIDVKTIQVFASKDEK
                     LKDFIFNLATKSIKLGITYKTVDKIMPGLII"
     gene            10810..11313
                     /locus_tag="KNP36_001205"
     CDS             10810..11313
                     /locus_tag="KNP36_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873093.1"
                     /translation="MTDKIIIASVDGEEMIFRTEMKKLEKGDSLIVSVNGVKRLALFI
                     RYISTCEEYIEDIAFQKVDEILYENTIAKEKERVKKVFKDKCMKNYKPIVNTEIDSYL
                     RECGFNCDGRQFFKSIDNTQILISRDCDKDVLTVSKGLTITKTDITNKNLITVIKIIN
                     NSLLIVR"
     gene            11373..13598
                     /locus_tag="KNP36_001206"
     CDS             11373..13598
                     /locus_tag="KNP36_001206"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside triphosphate reductase"
                     /protein_id="HBF0873094.1"
                     /translation="MKNVIKRDGRIVPFDEKKIINAIEKSFLSLRNKGKSEVFDRELA
                     TLIAKKIKNKPCEKMHIEDIQDIIEFSLMASKKKDVAKEYITYREKRNIARGRKTYND
                     YMSIVNTESNDITKENANMNADTPAGMMMKFASEATKTFTDHVLLSEEAKEAMMDNYI
                     HIHDKDYYPTKSLTCIQHPLDKIFNNGFRAGHGSSRPTKRIETSSILGCISLETVQNE
                     MHGGQAIPAFDFYNAPSVRKTFIEEIKNIEIKDDIDLSHLYNIEIEDYIIKDLKELDS
                     EKRNVQHAINRTVWRVHQSMESFIHNMNTIHSRGGNQVVFSSINYGTDTSAEGRCIIR
                     EILKSTYEGVGNGETPIFPIQIWKVKEGVNYNPTDRNYDLYELACKVSAKRFFPNFLN
                     LDATFNKHVKWKMCDPNRYIYEVATMGCRTRVFEDLHGEKTSIGRGNLSFTTLNLVKM
                     ALEAKEKYPNNEANRVAEFIFLLDKYSDVVARQLYDRYLFQCTAKAKQFPLLMSGLWK
                     NSENLNPNDDVSEVLKHGTLGVGFIGLAECLIALIGEHHGESEKAQKLGLEIISLLKS
                     KVEKYKKKYNLNYSVLGTPAEGLSGKFTQKDKKIFGEIKNITDKDYYTNSSHVPVWYN
                     CNVEHKAKIEAPYHELEGGGHIFYVELDGDATHNPKAIMKVVDLMKKYNMGYGSVNHT
                     RSRCMNCGFENADSELKECPKCGSNSINIIQRITGYLVGTTDSWNNAKLAELKDRVTH
                     G"
     gene            13591..14088
                     /gene="nrdG"
                     /locus_tag="KNP36_001207"
     CDS             13591..14088
                     /gene="nrdG"
                     /locus_tag="KNP36_001207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HBF0873095.1"
                     /translation="MDKDYIYILDIKHDTIVDGEGFRTSIYCSGCNHMCRGCHNPQSW
                     DIKNGTLTKVLDIYKEIISNKFSDVTFSGGDPLLQLQGFVHLAKLIKKNTNKTIWCYT
                     GFKFEELITDNEKLELLKLIDVLVDGKFEEDKKSLELIFKGSSNQRIIDVQKTLYEKQ
                     IVLYE"
     gene            14289..14696
                     /locus_tag="KNP36_001208"
     CDS             14289..14696
                     /locus_tag="KNP36_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873096.1"
                     /translation="MYFETDIIKNKNTVNKIIKYCGGNTEKLKDWLKEIENKSISSLE
                     ELKEYPLKRNYKFVFSKEEAPNLDKLIKMKLRDNCLEKCEICSLENLLSMLNDEILDL
                     NKEDISYEDNIEWIENCKEELIKLKVGSICIDW"
     gene            14717..15028
                     /locus_tag="KNP36_001209"
                     /pseudo
     CDS             14717..15028
                     /locus_tag="KNP36_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900673.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            15119..15469
                     /gene="tnpA"
                     /locus_tag="KNP36_001210"
                     /pseudo
     CDS             15119..15469
                     /gene="tnpA"
                     /locus_tag="KNP36_001210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003378761.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
     gene            15487..16926
                     /locus_tag="KNP36_001211"
     CDS             15487..16926
                     /locus_tag="KNP36_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015978935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0873097.1"
                     /translation="MSNYILTLQLKTEKFQEDIICNAFDKYRKVYNSCLSELFKRYNH
                     MIESKEHQANCKYKGKDRNKIFSEINKKYNLTEYSLHKFVKFIGKYYKLHSAITQKIA
                     TRCFNAFNKYIYHQAKRVNYIRYNELTSIEGKQNSTGISYKDGIIKFNKMTIPVIIKN
                     NDNYAQRAIQDKIKYCRILKKEIKGKIKWYVQLVLEGIPPKKTTNQGKIKGQIGLGNV
                     GIDIGTQTIAISSKCDVKLLELAPNVNNIDRQIKLIQRKMDRSKRATNLNKFNDNGTI
                     KQGNRDKWIFSNHYLKLKRLRKELYRKQAEIRKQDHYILINKLLNLGNKFYVETMSYK
                     RLQTRVKDTTINEKTGRINKKKRFGKSLANKAPSMFLTMLDNKLKYNNERLYKIDTAK
                     CRASQYNHFSDEYNKKELKDRWNNGMDIQRDCYSAFLIMNVNEDLKSINRELCVKTYD
                     NFKILHDKEINRLKKLKLNGYKLISSMGI"
     gene            17175..17351
                     /locus_tag="KNP36_001212"
     CDS             17175..17351
                     /locus_tag="KNP36_001212"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873098.1"
                     /translation="MYDYGMSLSSIMKVILNHQEDIEKLKEEEVAEFIKNKLENEHDC
                     DELKIISEVFNEIY"
     gene            17338..17448
                     /locus_tag="KNP36_001213"
     CDS             17338..17448
                     /locus_tag="KNP36_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase"
                     /protein_id="HBF0873099.1"
                     /translation="MKYIKHVDNGVMRAIGIDNYKPLLNIIKEKVNLESN"
     gene            17477..17944
                     /locus_tag="KNP36_001214"
     CDS             17477..17944
                     /locus_tag="KNP36_001214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873100.1"
                     /translation="MGLDLGFYSVKTKVTDLDIYLNKTRGEKYKELNNDEEEFYKFEE
                     LLDIDISLEDWSVIRMIYKAKWEKGYESYEDEAILITKEDLEDYIIPFLKQKDINSKI
                     YNKDKEYYYKNDKKVTVDDRYTQEFWDLVLKEFQKMLNIIDFEKHSLIIMYWY"
     gene            17980..18360
                     /locus_tag="KNP36_001215"
     CDS             17980..18360
                     /locus_tag="KNP36_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="HBF0873101.1"
                     /translation="MKKMYIAINSDLNMSPGKVGAQVAHAVYDYLYNKILDTVSCSYE
                     TEIIAHELIDLKCDLTSFKNNGDTICILKAKEAQLLKFKEKGYLTIVDRGLTEIPKNS
                     ITCVNLGIFNEDEIPSTIKRLRLY"
     gene            18376..18531
                     /locus_tag="KNP36_001216"
     CDS             18376..18531
                     /locus_tag="KNP36_001216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873102.1"
                     /translation="MYSKGDVVKVWCYQCERIEFQEFVGYFNSYFDNYKLKKRWKCSK
                     CDVINNF"
     gene            18558..19004
                     /locus_tag="KNP36_001217"
     CDS             18558..19004
                     /locus_tag="KNP36_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873103.1"
                     /translation="MKIKKIILGLDNLENVELGIGDVGGFYLDNIHEIIGGFALSYIG
                     KCKKADYLHIQIHKRVDEIQRLHDYKDITNVKIEYEDGSVEDIYVPYKQEGDFLGLDN
                     LYQTSFISKQGYLHIVISKDKTVEEVFNEEFEDDEGVEFSFNMYGI"
     gene            19282..19446
                     /locus_tag="KNP36_001218"
     CDS             19282..19446
                     /locus_tag="KNP36_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873104.1"
                     /translation="MTDKEMEEYIINLIKDKIKEEYGENILPEILMEKFIKLERKGSV
                     TVDVRDLIEG"
     gene            19490..20743
                     /locus_tag="KNP36_001219"
     CDS             19490..20743
                     /locus_tag="KNP36_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RtcB family protein"
                     /protein_id="HBF0873105.1"
                     /translation="MEVQGKYNKAKIFTENVDSITIGQIINLCNQKEFKESSIRIMPD
                     CHAGKGCTIGTTMTISDKVVPNLVGVDIGCGMATIPLEKYINNINYTKLDKIIRDYIP
                     HGFKIHNKSREKLLKNLFNIDINNLRCEVNKNRAYMSLGTLGGGNHFIEVDKSEKGQM
                     YLTVHTGSRNLGKQIADYYQDKAIKYCIEKYKKSYDDAKEFLISTLKKDNKEHLINKY
                     LKDLSDRKLNKPHDDLCYLENDLMEDYLHDMSIAQKYAAANRMVIIADILFKYNSLEV
                     NYDHFIRDIKCDVIECIHNYIDMDSKILRKGAISANKDETVIIPVNMRDGIILGKGKG
                     NSEWNYSAPHGAGRILSRGKAKEKISLDEFEESMKEIFTTCVGQSTLDEAPQAYKPIE
                     DILNNIGDTIEIMEVLKPIYNFKSN"
     gene            20785..21687
                     /locus_tag="KNP36_001220"
     CDS             20785..21687
                     /locus_tag="KNP36_001220"
                     /inference="COORDINATES: protein motif:HMM:NF014342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873106.1"
                     /translation="MIKLITHNDLDGVSCCIIAKYILREQIDVNYCNYKNINDVVLDT
                     LKNHDKYEQILITDISVNEDVAKKLDRIKNKVQLLDHHPTALFLNNYDWANVEIECNK
                     GKTCGTQMLFNYLQRYYDDTSESTLKYFIELVRRYDTWEWKDKYNDLDAKYLNDLMYI
                     MGIEDFIMDMLTKIDSDEMCLFDKLSLKLLEIKQKEIDRYVEKKDENIMVKEILGYNA
                     GIVFAENHISELGNKLSELHPELDFIVIINREIISYRTIKDNINLSEIAKVFGGGGNP
                     KASGSQIDESCIDNYIKDIFNIKS"
     gene            21795..22073
                     /locus_tag="KNP36_001221"
     CDS             21795..22073
                     /locus_tag="KNP36_001221"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873107.1"
                     /translation="MMIDKFNYELYNEFPHLSPIIELYNLNIEYIREVVSILINTDMT
                     FQRFKYSKSRVECSMKAYIISPNSKLSVVFAYDCELNGIDLDNLKAII"
     gene            22120..22530
                     /locus_tag="KNP36_001222"
     CDS             22120..22530
                     /locus_tag="KNP36_001222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873108.1"
                     /translation="MCKFCESIIDNTKDILLTSRSRLLEDNTCEIIAEDNCNNCYDGC
                     YEYFKLNGYKIRGNTYVNVDYYKKIRKIIIAPCSESVHINYCPYCGKQVSKDIKDFNC
                     IPEHIVDVRYKNGDVYDYDMEKSVQEVMDNANNN"
     gene            22561..22734
                     /locus_tag="KNP36_001223"
     CDS             22561..22734
                     /locus_tag="KNP36_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873109.1"
                     /translation="MNLWSKIEEPVMRAVSGIVFNIWGNVCFSIYYIEENKQIELEIY
                     DRPYRYEGKKNSC"
     gene            22844..22987
                     /locus_tag="KNP36_001224"
     CDS             22844..22987
                     /locus_tag="KNP36_001224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873110.1"
                     /translation="MNKGIKNYITAVNYLLDNLEYMMEDDEFNNEKLQKRIDVIRKFE
                     REL"
     gene            22989..23294
                     /locus_tag="KNP36_001225"
     CDS             22989..23294
                     /locus_tag="KNP36_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873111.1"
                     /translation="MGKIKNGEIDTEDYRLFKNIQKEKDRVYSKYINEEYIMEEFINY
                     LRLEDKDYTTEILERYARYIDENLDNRCPYCVYNICSEHDNCFDGILENLKEKIKIK"
     gene            23452..23652
                     /locus_tag="KNP36_001226"
     CDS             23452..23652
                     /locus_tag="KNP36_001226"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873112.1"
                     /translation="MIKERFKAKDSFNMDEFTKIWLMDFKEDFDLSLKKMIENTIKKS
                     IKDTYEETERAITNIENLINKL"
     gene            23857..24141
                     /locus_tag="KNP36_001227"
     CDS             23857..24141
                     /locus_tag="KNP36_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5052 family protein"
                     /protein_id="HBF0873113.1"
                     /translation="MKKFLLTGLLGTMLIAMSGCTGIQSSMKDAESDVSGLNRTVNVY
                     SDNGEVLKTYTSKSMRVKDGDGGTITLDFDGKRVIICNAHVVIEENSSNK"
     gene            24153..24320
                     /locus_tag="KNP36_001228"
     CDS             24153..24320
                     /locus_tag="KNP36_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873114.1"
                     /translation="MFKILKTILIIIWVVDILNFPQFQFLDTTYPINTLAWLLIWILI
                     PSSSIYIDKKE"
     gene            24499..24651
                     /locus_tag="KNP36_001229"
     CDS             24499..24651
                     /locus_tag="KNP36_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873115.1"
                     /translation="MKITISIEEAMDIIKQHYENKGIEIKDLSFNLEKTGMVRNIKFK
                     GEIILK"
     gene            24685..25284
                     /locus_tag="KNP36_001230"
     CDS             24685..25284
                     /locus_tag="KNP36_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873116.1"
                     /translation="MFISSTNRSDARSFHISDYYRTPITKIKEFLTEFSRYENILNSN
                     IKILDPCAGGDNTNPMSYPTAIQEFSNQEISIDTVDIRDDSRANIKQDYLKFQPKEKY
                     DVIITNPPFNLSLDIINKALNDVREGGFVIMLLRLNYLGGKVRQRLWGNNMPKYIFVH
                     NRRMSFTDDGKTDSIEYAHFVWQKGYNPKFSQLKVLISQ"
     gene            25310..25522
                     /locus_tag="KNP36_001231"
     CDS             25310..25522
                     /locus_tag="KNP36_001231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873117.1"
                     /translation="MEINRRRCEYAARTGRYPNSLILWEGYYSLLNIQYIEDKTRGYI
                     TKFNGMDVIKCNDFLKIELFEKNINN"
     gene            25551..28622
                     /locus_tag="KNP36_001232"
     CDS             25551..28622
                     /locus_tag="KNP36_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBF0873118.1"
                     /translation="MRYNNYHSHKIYSNIRSLDVITKPQQYIDRAIKLGQNTYFTTEH
                     GYQGNVYEAKTLCDEYKLKMIIGAEFYYVNDINEKDRGNYHLIVIAKNNDGYKQINKA
                     LSLANKNGYYYKPRIDEKILFEIFKPGDVVITTACVAGILKLENREELILKLKNYFKN
                     NFFLEVQSHPHKTQALHNKDVLELSNKYNIDIIHANDSHYIYPEESKYRTKFLKAKGI
                     NYPEEDGFILDYPNSEDIFKRYEKQNVLTKQEVERALKNTLIFDECEEITLINDDIKL
                     PSISKNPNKELKEILNKEWLEKRKNIPKNRWNEYLDAIRYEFDIIEKTHMEDYFIIDY
                     KIVQRAKQEYNGLLTKTGRGSAPSFIITNLLGLTEIDRLNAPVPLFPTRFMSVERILS
                     AKSLPDIDLNAEDAEPFIQSTRDLLGEENCAWMISYKPLQDASAFRLWCKANDMKLSE
                     YDEVAKNLDKYTNDVFWKDVIKESKVFVGVVESVSFSPCSMLIYDRPIDEEVGLLKTK
                     DGVCCNIDGYYCDKYKYLKNDYLTVKVWSLIRKICELANISIPTIEELNILLDAKTYD
                     IYKDKLTCTINQVDSDYATNLASKYKISSVAETSAFVASIRPGFASLLDNFINRESYT
                     TNVKELDILLEDSYHYLMYQESIMKYLIWLGIEESESYDIINKIKKKRFKEKELKELH
                     IKLKNNWIKKVGTENNFEDTWQVVNDAASYSFNASHSLSYAYDSLYCAYLKSHYPLEY
                     YTVAFNLYNEDTERTRKLTDEIEYFSIKLENPKFRFSKSEYFFNRDTNSIYKGIESIK
                     FLNSDIGEYLYSLKDNKYDSFLELLIDLQGHINSKQLSILIKLDFFEEFGKSNKLLET
                     YDIYNSIYSKKQFKRDNLPCDINTMRKYSNKETEKIFKEVDTKELCSYLESQIENTDI
                     PTNEKIQAHFEFVGSCNIKDSNSNPRYCLVIDIDTKYSPKVTLYNISSGNIKIFKVSK
                     PIFEDNKIDVYDLVYLKSIKEKAKSKKVDGKWIRSNTETEWWIQEYWKIEN"
     gene            28725..28976
                     /locus_tag="KNP36_001233"
     CDS             28725..28976
                     /locus_tag="KNP36_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873119.1"
                     /translation="MISILIDEQRYYSLLEEKKDLSMRIDELKEENAFLKQENEEYEE
                     ILNEWECVRKEIVATCKKKEILGEKPSELEMVLQKIEDI"
     gene            28976..29296
                     /locus_tag="KNP36_001234"
     CDS             28976..29296
                     /locus_tag="KNP36_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873120.1"
                     /translation="MSVNKIYEKKEYIIIKSKSGYIVYNTNKEFKEGHTHLKSYNAAK
                     TAIDLVIKRRLPKSYSIYFLTSLMRISNDVQYIKHISDIVYIRNNKGLKEKYINSKNI
                     KKNY"
     gene            29371..30492
                     /locus_tag="KNP36_001235"
     CDS             29371..30492
                     /locus_tag="KNP36_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112623.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PcfJ domain-containing protein"
                     /protein_id="HBF0873121.1"
                     /translation="MKSYKEKQFLVFEFEDGKNVKYNLATGEYVGKSGRIVKDVCTQL
                     RGYNLHEVINSFEDENYKCFLNFVDGRVNRSKSSRAWGRRVERIRNIGSFLNEINNYS
                     EYEQLFSAGLKKIIYPIHCDIKSIPKGLISICRNYSITLSDRLIQGYSKNPNLYNNLL
                     SLELNSIRKTNLISILDSGYDRMIFDRLIDIYKYKPQSLINYIDNLMTYEALNGLEST
                     LNELYDYVVMMSVISDKYEKYPRHFLTTHKIASRNYNRLKTQFEEEVFNKRIDKSLEY
                     SYQDYKFIYPKNTNEIKDEAVQQNNCVSSYIQNVIDGKCHILFMRKKDNPSKSLVTIE
                     VRNGKIVQAKGKYNRDVNEREQEAIDKYNNRIERMKKIC"
     gene            30486..30929
                     /locus_tag="KNP36_001236"
     CDS             30486..30929
                     /locus_tag="KNP36_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873122.1"
                     /translation="MLIEGTKIRLMKEIQGFEMLKIGDIFVITSVGNNGAIHFKTNYG
                     MGFMNYSELKKYFEVAIETKKKEHIWSEWRTATVFGTNKTCTYRTNGKKVEVRMGDFK
                     ASATCHDSDEFELNKGVELCLARIEVKKANKQVNLVLDKINNKEI"
     gene            30939..31094
                     /locus_tag="KNP36_001237"
     CDS             30939..31094
                     /locus_tag="KNP36_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873123.1"
                     /translation="MSCKFKERCENKNRDCDYCCYNPNAYLEDAFEWNGEGRKPTDEE
                     LDDALEE"
     gene            31138..31698
                     /locus_tag="KNP36_001238"
     CDS             31138..31698
                     /locus_tag="KNP36_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873124.1"
                     /translation="MRWRNILVTSVLVMGSSIHIFANTKEMSTSRMDKNIVADTAKNI
                     NLMYKYEWEQHKNSSEYKLEIKRINLEKDLGIKIEKLIPVTWEVSYYTSLNCENSKYG
                     AITATGEKLQYGFVANNYLKFGTKILVDGNLKVVKDRGSNKYFGNSNAIDVFVPKLEG
                     ESDYKYYKRVNNMGRHYKEGYIIVEG"
     gene            31710..32378
                     /locus_tag="KNP36_001239"
     CDS             31710..32378
                     /locus_tag="KNP36_001239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873125.1"
                     /translation="MNVNGIKIPGIIDVSNVYVYGIKESIIASGYPMYEQQVIDMKKI
                     NISEKDLKRANQLGKSKQGSGHDCFSKGIIIQMDLQWSEYMWRQWDRYHHNDYVSSQS
                     KMHRLSKFNLDDMCNKYVDKNTINFLNELIHEYNNFEELKLNNSNNIILRNGEKVEVT
                     KETLWKIIISNCPSGLMLTARVTLNYLQIKSMINQRENHKMEEWRILCDFFKTLPKYK
                     ELMM"
     gene            32424..33317
                     /locus_tag="KNP36_001240"
     CDS             32424..33317
                     /locus_tag="KNP36_001240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873126.1"
                     /translation="MAEKRINYNQVFVSGEVLDILNIARMNQGTGQEAIRFTLKVETA
                     PNESVNVDYFTSMFKSDGSPNQMFLGIETIANEIKTRAEDGKGDIVRCVCSLDNNLYY
                     KDGEKKERFQISGTFCNREKYDDKGNPIDDKGEVVKSIKASQVWRVYTLIENIEEKED
                     DLGKYLEIKGLINKYGKQGCNMTFRIHNEDMIEGFKSLYKIGDVGLLEGTVKSMVVSK
                     SAGFGSRIKKSAFTFLEIEGGDEPLKDGDKIFSDKNYPFTDKNIEAMREKIKEKDKKE
                     KQRDIDKNGKTIEIRDDDVPF"
     gene            33357..33914
                     /locus_tag="KNP36_001241"
     CDS             33357..33914
                     /locus_tag="KNP36_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ERF family protein"
                     /protein_id="HBF0873127.1"
                     /translation="MEVKEKTMNDGFKKVVNEEIKTYISNLYSDRIDGLKESDSQIEI
                     TKALIAFHLDIESIPKDNTNPFFRSKYANLDTILKAVNPLLAKHDLILMQSAEDAGND
                     KVYIKTKLKHSSGEYIESNSAPFKPAKTNDIQARGALETYLRRYAVQSVLALSFEEDD
                     DGNSLTNKSKGKSEEENSTIKKSRV"
     gene            33975..34526
                     /locus_tag="KNP36_001242"
     CDS             33975..34526
                     /locus_tag="KNP36_001242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873128.1"
                     /translation="MNCKCRFCKKKLNTNDAYKVEHITSGGNKQNRYYCNEQEYRKEQ
                     QDIYFWKQCQLGIDYIMGYTVINNQKNKMLQEIIKGGYTREELYDCIIEKKDEVIELL
                     NYRKDIEEEYPKLCYVFTILKGSIRDITIKNKQMKYEKENERIYKEVEKSEEYYEIIA
                     PKKVIYNKRQSLFDKVKGVYQDE"
     gene            34567..36093
                     /locus_tag="KNP36_001243"
     CDS             34567..36093
                     /locus_tag="KNP36_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873129.1"
                     /translation="MVLGTMLKSLTLFSEYKISESDFIIDKVKFFFSLGRIMSKTHNE
                     LDEISVAKFVSSNKLKSEYERYGGWNSLSSAMEYGKETNIAAYIDDLAKNNLLIALDK
                     RGFNVIKEMEHNGLKFIPFEIFQSMKCREVEEFYEGLISSCSVNSIKNNMKVENLLLT
                     KDDREKLKQKTEAGTPYNIIFEYTEKEIGLSNNEESKYIYSLPILSNRTNGIGKGGGI
                     NIIAGFSGIGKTTLLFFNYILAMIYRGEKIVIFANEQKSQYFKSMLVSFIAYNIFNYH
                     DLDRNKIDNGDFTDFEEDLMEKIEKFLRDRCFAENLKFIYMEEFEISEILRKSKELVT
                     HQGFTGIAVDTFKSEDSSDAHYTGKLIENSKLLDSFGNKYNVITMLSMQLLTAQENKS
                     SYLSAGDLSEAKAVKNVCGLLKLMRKVVNELELDSTNKKFFLKPYKLKYNKLKKTTER
                     EYIQFDAKDLQKEYRLLFLNKSRRGQDGDVILLRFYGKTGRLEEIGRCEKVYRGQLSY
                     "
     gene            36103..37164
                     /locus_tag="KNP36_001244"
     CDS             36103..37164
                     /locus_tag="KNP36_001244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873130.1"
                     /translation="MEIKDLTNEQVINFMEYLGSDLSPKSNDRQLIFNTCLCHNGDSY
                     KLFYYTESKTFHCYSSCGHIGSLIDLLIHINKYEFKDAINEIKDFFGISNQPMLRKGF
                     RIKKKVEQIHDIKDIQIELLPTPKKPYVYKTFQQVPIEEWENENISFEVLKTYQVYYN
                     LYENQIVIPHFCWHDRARPVGIRVRNLDEDKAKSFGKYIPLWYDNRCYNHRLSLNLYG
                     LNVNKKSIKNSKKVIVFEGEKSVLQMATMYKNNPSVAICGSNFSREQKKILIDLGIEE
                     LIIAFDRQFKVKDDEEYVIWRDKIYKLVQDIKDVVNISVIWDKYNLLGYKDSPSDKGK
                     TIFEKLLKNRINIENFVKQ"
     gene            37269..37541
                     /locus_tag="KNP36_001245"
     CDS             37269..37541
                     /locus_tag="KNP36_001245"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873131.1"
                     /translation="MIKFLIKNVHMGDKLYCINNIGNYKKGEIYTVSDTSFFGLFHKT
                     KGENCLPIECYFIHLPKKEELESNPKSMTKEEIEDELGYKIKIVSK"
     gene            37562..38413
                     /locus_tag="KNP36_001246"
     CDS             37562..38413
                     /locus_tag="KNP36_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873132.1"
                     /translation="MSIFNKKYGRNVKITEEEPPSPPPKQPIYNRDNIQYDKEMERKL
                     LDIDRLKIELEKEKKIEEERKKVERVKENEGKEWAWVEGYKCTDKNMKCKEFQYELNK
                     AYSMDGDDINIWNWGFHLCLDLGDVFQYYAPNLSNRFFKVKALVKKADKYKYGKEYGE
                     VTLLSGSVLRGHKINKIAAKEIIFLEELTFDKLKLHIQNSFPEVNTKSKWYAICKLGE
                     QEYYHRMFMNQMKKIRFSDTFSQLLFDECRNYCEILEILNKAIAYSKENLSKDMIIYL
                     LMKDIRK"
     gene            38437..38880
                     /locus_tag="KNP36_001247"
     CDS             38437..38880
                     /locus_tag="KNP36_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873133.1"
                     /translation="MDKINKIDLIKLKEMNIYDNYQLKKIASKMILHLRYEIMDFCGC
                     GSPEDISFMIKGVLTAIQNKEKNCNLEYTERCYIFEIEFNNVCGIIGSKNDLIQEFIL
                     NALNSYGLLEHGSSIWGSWLSDYGKQILCAFEIVGDCILDVSYLD"
     gene            38907..39566
                     /locus_tag="KNP36_001248"
     CDS             38907..39566
                     /locus_tag="KNP36_001248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003401688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine protein phosphatase"
                     /protein_id="HBF0873134.1"
                     /translation="MIKYVMSDLHGMYDKFISMLEQINFNSNDHLYILGDVLDRGDKS
                     LEIIDYIRKYKNITLLKGNHELMFQESYTDVNSSFLWFYNGGKDTFYDLGMKSYEYKE
                     NFYKYIKNLPYLEIIDNFILVHAGLYLPNNYENLSIEQIIELQEEDICVWDRTILNTN
                     KHIKGYTIIIGHTPTQNIKDYEKAEIYKQEGIINIDCGACFDNGKLACLRLDDMKEFY
                     I"
     gene            39577..40104
                     /gene="yyaC"
                     /locus_tag="KNP36_001249"
     CDS             39577..40104
                     /gene="yyaC"
                     /locus_tag="KNP36_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protease YyaC"
                     /protein_id="HBF0873135.1"
                     /translation="MDILKISYNNLNAISKISEVLRDIVNEDTLIVCIGSDRVLADSL
                     APMIGSILEKSTIRNKIFGVLGDSIHALNLEQKIQAIKNNYPNSNIIAIDACISKISD
                     KGTIIISNKPVKPGLGVDKKLLEVGDYSIVGIIGRNKYDIYDTSDPELILDLADVISK
                     SLISILLEKEERMIV"
     gene            40101..40355
                     /locus_tag="KNP36_001250"
     CDS             40101..40355
                     /locus_tag="KNP36_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873136.1"
                     /translation="MIQEVRQEILLKNGLILYTGDLVEIKYKSDEDVIEHTCKGKIKE
                     AKELFIKLDTSKKYKTSERMIYSWELKEIKKVDDEDEKDN"
     gene            40339..40596
                     /locus_tag="KNP36_001251"
     CDS             40339..40596
                     /locus_tag="KNP36_001251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873137.1"
                     /translation="MKKIINSKYRALYLFIFFLIFNLIYSLYFGRNTEIGFYSSTSCI
                     EEYILDIITSIGLFFSMMLAGFDVTENFINSLRDYCEEDAK"
     gene            40607..40816
                     /locus_tag="KNP36_001252"
     CDS             40607..40816
                     /locus_tag="KNP36_001252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873138.1"
                     /translation="MELKDYISKVELNDMPLTLDNKYMLNEISISEDSKIFAVKDTSG
                     ITSYYTEIEFNKLFRGINSILENII"
     gene            40891..41730
                     /locus_tag="KNP36_001253"
     CDS             40891..41730
                     /locus_tag="KNP36_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="HBF0873139.1"
                     /translation="MEKELYSFSKLNAFNTCPFQYYLTYVKNLNREQSCYGYYGNELH
                     SLLEQLQQRKITNQEAIQKYNEVIEYANLMDYNFPTPNSRINYLECILHYIENFVPIE
                     CDRYYIEEYFEFDINGITMRGYIDLYYIIGNKIYVIDYKSSSKFSKKDLPKKSMQLIL
                     YAMYLKEKYPDKIIEYVAFDMCKYMNNEKGVLIERNKIDSINDYERAIVKIKYTKELE
                     KQLIDFVVDTVTQIKQLDSNDESVWCKSDDKSNQFFCKTLCSHYNKGCKHKENKSFRK
                     SKS"
     gene            41768..42064
                     /locus_tag="KNP36_001254"
                     /pseudo
     CDS             41768..42064
                     /locus_tag="KNP36_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895083.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            42081..42662
                     /locus_tag="KNP36_001255"
     CDS             42081..42662
                     /locus_tag="KNP36_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HBF0873140.1"
                     /translation="MDKLKNIFVFLGYSGSGKDSIVTEISKQFNIPILISHTTRPPRN
                     YLEIINKTYYFVDNKFFKKEKNNFIEMRKYIVHDGSTWLYGIHKSELENKKYALTIVD
                     ASGYKALEKYFTGTKTKLVPFFINADEDTIRKRLIDRGDNLKEIERRLVDDKIKFKEF
                     LNSENYIVIANNLSITNAVEQVKIHMKEGIQWS"
     gene            42653..43147
                     /locus_tag="KNP36_001256"
     CDS             42653..43147
                     /locus_tag="KNP36_001256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="crossover junction endodeoxyribonuclease RuvC"
                     /protein_id="HBF0873141.1"
                     /translation="MVLALDVSMSSTGWAVINRNKNILKYGKIVTKKDKFKSEDERMC
                     YICNAIQELIITHNIQIVLIEDQFTSRNSKTILSLRKLLGAIMRTVKLNNIEIEYMYP
                     VSIRKYLLNNGKAKKEEVAAYVRENIIDIGEYIDRTCKAKTSDIYDAIALGIAYLNKL
                     DTNR"
     gene            43171..43674
                     /locus_tag="KNP36_001257"
     CDS             43171..43674
                     /locus_tag="KNP36_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyuridine 5'-triphosphate
                     nucleotidohydrolase"
                     /protein_id="HBF0873142.1"
                     /translation="MSINVKIKKLNQNAIVPSYAKEGDSGIDLYTLKDTVIPAKSAVA
                     ISTGISLEIPYGYEMQVRPRSGISLKGMFFTRYVTIYDKVQPKKQIRKIFVAHPTVRL
                     GTVDSGYRGEIKIITYNEEDFDILIPKHTKLAQGVFQQVPRAILKVVDELTSSERGSN
                     GFGSTGI"
     gene            43839..44012
                     /locus_tag="KNP36_001258"
     CDS             43839..44012
                     /locus_tag="KNP36_001258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873143.1"
                     /translation="MYRYDDYVNLINDLELPKEIRNKCVRVIMTLENMQDIMVVHKFK
                     TYVVNEKYIEKVA"
     gene            44132..44881
                     /locus_tag="KNP36_001259"
     CDS             44132..44881
                     /locus_tag="KNP36_001259"
                     /inference="COORDINATES: protein motif:HMM:NF019976.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009617778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NERD domain-containing protein"
                     /protein_id="HBF0873144.1"
                     /translation="MFKEIFEKVFMSEEVSKTVKEVNNIIKDTKIQVKGGFGELRLDF
                     ILSRLGKDYIIIKDIIVPGSNKTTQIDSIVISMYGIFVIECKNFSGYIYGNDKDKVWT
                     QIVGKTKNTFYNPVRQNYAHIKAIENIIGNKYNIYSIIVFSDKATLKNVMISGNNIIV
                     INESEILSTISKCKDVTIDKEEIKIIRDKIFDCMKTTNQNTREHVRNLKNITEEDKCP
                     RCQIGHLIKRKGQYGEFWGCSQYPKCKYTRK"
     gene            45170..46282
                     /locus_tag="KNP36_001260"
     CDS             45170..46282
                     /locus_tag="KNP36_001260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBF0873145.1"
                     /translation="MNAFIRKRNKNYVVYLEFRDDESGKRKQKNMGAFDKKRDANKRL
                     AEVKDSIYKDSFLVPNEITLAGFILDFLEKYKDNISASTYKSYIAICKNHINPSIGKY
                     RLQELRNIHIQNYIDDLAGNLNPQTIKVHINVLRLAIKRAYRIKLIKENIIDGIESPR
                     IKKFKNEIYDKEQMLKLLELAKGTNMELPISLAIGLGLRLSEVLGLTWDNIDFDENTI
                     TVNKITSRLDGSVILKEPKTESSVRKIFAPIELMNLLKNYRLEQNKKLLRSIVRNEYN
                     LLFFDRKGNPIAEDVMSKKFRKFLENNDLPHIRFHDLRHSHVTLLINSKVPIKVISER
                     VGHSNINTTLNVYSHVLKEMDKEASDRISENLFKAN"
     gene            complement(46780..46974)
                     /locus_tag="KNP36_001261"
     CDS             complement(46780..46974)
                     /locus_tag="KNP36_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873146.1"
                     /translation="MPELEINISISIPIFLVISYLAIVSIVMLGISALNNFTNITSVP
                     INALGSTVGFVIFQLLVSFF"
BASE COUNT        20510 a         4121 c         8048 g        14850 t
ORIGIN      
        1 taattacttt gatgtatagt tttttcttat tttctaatta ttgaatttaa tttttgtatt
       61 aattgctatt aataatttct gtattaaact aatgagtaag ttataactat gaaacttatc
      121 ttacaaagtt aataaatata tattgcatta agtaataata taattacatt caaagcgtta
      181 tataaatata tattatttaa tacttcatat cttatatatg ttatcatttt tatttacctt
      241 atttttacaa attattccat aagtatatta taattatctt gagggaaata atcatataga
      301 gggagaaatt agaaaatgga tagatttgaa gtattaaaat atctaaaatt taatgtttgg
      361 cattcagaat ggccattaga gcttctcaaa ggggctataa caaaggataa tgctactggt
      421 aatttattat tacaattaaa aatgtgtaat atatctgata aggagataaa gtctgcatat
      481 tttacaatag aatgttttaa tgatgcagga gatttaatag ataataattt aaagtatgtt
      541 tatcaagata taaacattaa accacatgaa tgtcttggtg atgatattgc tataaaaata
      601 aatgataata aaacaagagc aataaatatt atattagaac aagtagtatt ttcagatgat
      661 aaagttcata aatatgaaag agaagaaggt ttaattatac ctaaattaga taaaatagaa
      721 ttgttaaata tagaattatt agaagaactt aaaaaagatt atgaagaata tgattttcaa
      781 tatgaaatta agtacatgcc taatataata gaaaaaaaag catggagctg ttgttgtgga
      841 aaaataaata aattagaaaa agataagtgt gataattgta agagaagtaa aatactgcaa
      901 ataaaaaaga taaataaaaa ttatttagaa tctatttata aaaaaagcct aaaaaagaaa
      961 aaagaaatag aaataaagct tgaaaaagat aatagacata aattaaagaa cataaataaa
     1021 aataatagaa gaacatcaat attattaata agtatattat tgatttttat tatttttatt
     1081 ggtaaaaata ttattaataa gcatgctttt ttagatgaaa taaagtataa aaatgaatat
     1141 agtaaaaaaa tatctgtaga aaaagataat gtatatatgt taaaaaataa tggaaaagta
     1201 acacatagaa aagtgaatgg tgaaagtagt tctatacctg gttgggaaaa tataatatct
     1261 atagcatcat atgataactc aataatagga ataaaaaaag atggtacagt tgtttctaaa
     1321 ggacttggaa attcagattc agacaatatt agtaaatgga gagatataat agatatagaa
     1381 tgtgatagtg gaacttttat aggattaaaa aaggatggta ctgtcgttgc tactggaaat
     1441 aatgattatg gtcaatgcaa tgtgaataat tggtttgatg tagtaagtat agaaataaca
     1501 aaatcaacca ttgagtatat gaaaaataca acagtaatag gcataaaaaa agatggaaaa
     1561 gtattactta caggatatga tagtctgaat catagaaaag aaacagacaa atggagagat
     1621 atatcaaaga taaaatgtgg gtcttatggc atatttggaa taaagaataa tggcacagta
     1681 gttgtatcag gtagtgctta tgatattaag aattggaaag atatagtgga tatacatatt
     1741 ggattatgtg gaatagtggg tattaaaaga gatgggacaa taataagcac agatgaaaag
     1801 tttaatgaaa tcattaaaaa ttggaaggat attatttctg ctgaaataat agataatcat
     1861 gaaggaattt ctattgtagg aattaattca aatggagata ttttaacatc tagtagaggt
     1921 cagaatttgg ataatataaa aagattagaa gatgtagaat atataaattt tgatgactcg
     1981 attgataatt ttttagtagg tataagaaaa gataatgtaa tttttataag aggaataaac
     2041 aatactataa atgaagaata caacgaagaa atataaaaat aaatatttta atttggagga
     2101 atagaaaata tgaaaaatta catagcaaga tgtttatcaa atatgggagt attgttggca
     2161 ggtatacaag tattagcggg tataataatc atgtgtcaaa aagtagaagt tccatatgat
     2221 tatttgtcag atacttatga acaatatagt cctattatga ttggtattgg tgctggggtt
     2281 atagtaagtg gaatcgttat atgtttagtt ttaaagggat tagcagagtt agttgaaaat
     2341 tcagctgacc aaacacaata tcaaaaagaa atattaatgt tgttgaaaaa taataatgta
     2401 aatgaaaaaa ttaatgaggt taaaattgaa caacaattta caaatgagga attaccaaaa
     2461 ttataaaatg ttttaaatta tatactaata ctcagtacta attaaagtac tgagtatttt
     2521 tatgtaacag taaattatat taatataaaa atatattcta catacataaa atgataaaat
     2581 aaccatttat aatacattaa attacattaa atcaaaaaag tatatgtcga aaacatataa
     2641 tattaaataa atatatactt taaggagtga tttaatgatt ataactattt gcgaaaatga
     2701 tgatatgcaa agagatatca tctatgattt tgttaagata tttttaacta aaatcaaggt
     2761 aaaacattat gacattttaa tgtttaagaa tggggaagaa ctgttagaag aatatccaaa
     2821 caaagtggat ttaattttaa tggatataaa tttaggaggt agaaatggat ttgatatttc
     2881 aaaagatatt agaaaatttg ataaagatgc aagaataatt tttgtaactg tatcagagaa
     2941 atatgctatc aaatgttatg agataaatgc atttagatat atgataaaac cgatatatta
     3001 taaagaattt gaaaaatata tgcttgactt tgcaattgat tggagaaaaa gagaagctat
     3061 tattactata aaaagaaaaa aacaaataat aaaaatagag gaacataata ttttatttgt
     3121 tgaaatagtg aatagaaaat taagagttgt tactaaaaat gaagaacata taataaatga
     3181 taaaatggat atgtttgaag aaaagttaaa agaggatata ttttttagat gccataagag
     3241 ctatcttata aatttacttg aggtaactaa tttcaattat aatttcgttt atttaacaag
     3301 tgagaaaata aaaattaaag tagctcctaa aaagaccaaa aaacttaaag agaaattagc
     3361 aaattttttt agggaaataa tatggtaaat taaagaaaaa tttctataat cgaatatatg
     3421 ttcttgataa aagtatgtgt acaagatata atattattag taggaaaata ggaaaaatat
     3481 taatattttt gaacattttg acattaattg tgattttagt gttgaatttc tgttaaaaaa
     3541 atcttattat ttaatcatag aaatctactg ttatagagta gaagattgtt aattataaat
     3601 gattttaaat tatctgagat aaaatttttt gtttctgaaa agaacgaatg ttcgaatgag
     3661 gtgtagagtg agaggatgtt tattaaaaga tattagatta tcttacttaa ttcataatgc
     3721 atatatgggg gttctataat aatgaaaaaa caagtcacaa aagaaatact taaaatgcta
     3781 gaaaaaatgg atttatctta tttactcata attaaaagtt ttgtatctaa attaaaatag
     3841 cccttattgg gctatttact aagtttatca attactttct gtatgacttc tctttcatca
     3901 tcagtaagtt cagcaaatgt taagaatact ttttttaaaa attcatcatt acttgagaat
     3961 gttttaccca tcattgctgc taattcaata tcatctatat ttttaaacat ttctccattt
     4021 ccatttcgta accagtcctc atttacatta aaaacttcac atatctgaaa tataaatcta
     4081 tctgttagct ttctttctcc tttttcaagt ctagaaatag ttgcatcact tactaataat
     4141 ttttctgcaa attctttttg tgagagacct aatttaattc ttaattcctt taaattctca
     4201 ttcatattta cacctcctat tatatagtat attaataaaa attgacaatg tcaataaaat
     4261 aggaatgata aattgcaaaa agcaaaaaaa ataattgaca aatacagaat gtggtactac
     4321 aatgtaaata tacaaaacgc aattaataat ttgacaaacg caaataaata aggaggtaga
     4381 ttatttgtat aataataatg ataaaaaatt aataaattta tttgaatcat ttaaaaaaat
     4441 agactataca gaacaaagtt tagtgtattt tttatcttta agctttatag taaacagaaa
     4501 atgtcataaa gatgcaaatt tgtatagtag gagaggtgaa tgtaattatg aataatttaa
     4561 atatcaaagg aaaacaaaaa tttatggatt tagaaatacc tattatagaa ggaggttttg
     4621 gagagggtaa aaaatgtata acagataaaa ctatatcaga aatacacaat atggagataa
     4681 aacatgttag agaattaata aataggaaca taagaagatt tataaatgct attgatttta
     4741 tagatttaaa agtggtcgtt gataacgact acaatttaga agtattggag ttgcttagtt
     4801 atagaaaaat gcaaatatca aaagcaaata atatttatct tttatctgaa agaggatatt
     4861 caaaattaat taagataatg gatactgatt tagcttggga gatacacgat aaaataatgg
     4921 atgaatactt caatatgaga gaacaactca tagatagtta tatgatacaa gattctattg
     4981 aaagagctaa aagatggata gaagaagaaa aagaaagatt attacttaaa gaaacaattc
     5041 aagttcaaca acctaaagta gaatatcatg ataaagtatt aaatcctgac aaattagtta
     5101 cgacaacaga tattgcgaaa gatttaggaa tgacagcaca agcattaaat aaattactac
     5161 atttaaacag aattatatat ccagaaagaa taaatggtcg aataaaatgt tggaaaccat
     5221 ataaaaatta tttatggttg atacctgaat atgcagattt taaaataaca gaacatgata
     5281 cgcagcttaa atggactgag ataggtagaa aatggttaat agaatttgta gagaacatta
     5341 aaaaaataag ttaaatcaag aagttaaaat gtaccttgaa aagtagatat ttaaaaatat
     5401 aaaagatagg tgattaaatg ataaaacaaa tactaaataa aagaggtagt ctattaaatc
     5461 tagcaagtga gtatttgaca gaacaagact acctcaagtt tcaaggatgg tatacacata
     5521 gatatagtaa gctggatgct tatgatgctt ctataaatga atatttaaat tataaaaacg
     5581 acaaaaaatt aataacttat gtatttaatt taaaatttca agaagctctc atagaaatat
     5641 aatattacta aacatggtga ttgaaatgaa ttataattat gtaactaaaa ttgacttgaa
     5701 atatggaaat acacaatttg ggtttgagaa atatagcgat gctttagata agtacagaga
     5761 acttaaagaa gaatttaagt atgttccatg tattataaaa cttcattcat atgtagcgca
     5821 ccaagattta tatgtgaaag aaattaaagc tgatggtttt gaaaagaaat atttagatat
     5881 taaaaattta ataaaattgt ttaaagaaca taaacaaaat atatcagatg aactaagtct
     5941 ttgtgataag aaaaaggaag aagtattaca tgtaatagaa gaaatgaatt tagacacagc
     6001 ttctttaaat gataagattg ataccattaa agaattaaaa aacactttag ttaagagaag
     6061 gttggttaaa tatgaactaa ataaatactt tgccttttgt aatacattat atgaaattga
     6121 agaagagtta aaaaaatatg aatctaaata taaacaaaaa gaaaatcaag gaaaaagcag
     6181 attcaaaaaa aataaaaaat aggtgattag atggaagaat atcattttaa cttaataaaa
     6241 aagctttgtg ctgaaagaaa aatacacaaa ggttggttta gaaatattga aaaatgtggt
     6301 tgtggaggta aatgtaataa gaaaaattgt aagatgttag aaaaattata aggagataca
     6361 tatggaaaat caaattgaat taacagaaaa agatatagag aacactttaa gtgctttaaa
     6421 tattattaaa tatatttgta taaaatctaa acattgcaaa aattgtcctc ttggatatat
     6481 gaaaaatctt gatgaacata attgtatgct atatgaatta atagacaagg gtttacttcc
     6541 atgtgattgg tctgtaaaaa aagttacaag attgttagat acgacagaag aataaaacaa
     6601 aggagctggt taagtggagt tagatttcag aatttggaat ggatttagaa tgatacatgg
     6661 agaagaatta agattactaa cagaagagat gtttataaaa agtggatatt ctgaacaata
     6721 ctataacgat atttgtatac caagagtaga agatttgaaa ataatgcaat acatagggct
     6781 aaaaaattgt tttgaaaaaa agatatttca atatgatatt gttaaattta tctttgatgg
     6841 tgtttggaaa gtatgtttag taaatttatc tttgccaaaa ggagcaacag ttacatttga
     6901 aagcataggt ggaaaatata cttttaattt aagtgaaata ttttcaaaag ataggaaatt
     6961 agaaatcata ggtaattttt atgaaaataa agatgtaatc aaaaaatata atcttagtat
     7021 tgaataggag aagaaaatgg atgaaatgat aattagggtg aaaatgggag aaccattacc
     7081 aacactagga aagataatca aatgtactac atgtttaact aatgaagaga aatgttttaa
     7141 ggttaataag atatgtaaat taagttggat taacgatagg aatagtgaag ggttaattgt
     7201 agaatgcaaa ggtaaatata ttaaatatta ataagaataa tgaagttaaa atcaagattt
     7261 taatagaaaa ggagtgatta aaaatgaaga aaaatccaat aaaaattaaa aaatgtgact
     7321 gtggtggaga tatatatgaa cttaatacac aattaggcac tatgtatcaa tgtaaaagtt
     7381 gtggcgagat gtatagatag tgctgaaata ttagctaaag aagatgaggt gaagtcaatg
     7441 agtaaaaaag ataagttatc tatttttata agtttaatat taagacataa accagaaact
     7501 attggaatta aattagatga ctatggatat gcagatgtta atgaattgat tgaaaaaata
     7561 aataatactg gtagaaatat taatatagaa atccttgagc aaatagttaa agaagataat
     7621 aagcagaggt acagttttaa tgatgataga agcaagatta gagcaaatca aggacattca
     7681 attaatgttg aggttgaatt gaaagaatta gaaccgccaa aatgtcttta tcatggaacg
     7741 gctactagat ttttagagaa tattaaaaag gaaggtatta ttagacaaag tagactgtat
     7801 gtacacttat caaatgatat agatacggct gttaaggttg ggaaaaggca tggtgtacct
     7861 gtagttttaa aaattaatac aggaaaaatg tatgaaaatg gttataaatt ttatttatct
     7921 gaaaataata tttggttatg taagtatata ccatttgaat atgtagagaa aataagtaga
     7981 gtagttaaat aaaattatag aaaataggag gttattgaat ggatttcaat tttagaaaga
     8041 tttgtgaaaa agatgaactt actgatgatt ttattataaa aatttgccag ttgtcacatg
     8101 aggagtttgg aggcactatt tatgtaccat gtaatattca tccatgtggg tgggatgagt
     8161 tggaagttcc gaatccaaag gatttagatt cagataaatt aatggaagaa tttttattag
     8221 aatataaatt tgaatgtgaa aatatttcga gcaatattta tgatagtgac catccattta
     8281 taggcaaaac attgagagag attcttatga tagtggattg tagattcata attggtgtta
     8341 tataaggagg gtattaaata tggaaaatat agaattaaca cctagagatt attttgagga
     8401 tataaaaaat aaaaagcaaa aaaatacaaa tgaaaatctt gatatagtat atgaaaactc
     8461 tttgattctt ttaaacaaat atattgtaac tggtcaaaaa aagggtgcta agaaattaat
     8521 gtttttactt gaatgtattg aaaaagaaag aaatgtaata gagctgggaa tagatacatt
     8581 tgtgtataaa gaagatatag aaaaatatat tgatgatata tctaaaaata cagtaaaaat
     8641 aatagaactt gaaaattatg aaagagaaat accagatgaa atagtagaaa taatagaaaa
     8701 aacaaaagat atatttgata aaatgtatgt tttgtttact gattatacag gtaaaattac
     8761 aaaggagata agcaaagaga gaagagataa agacccaata ttatttggtg ttttttcaga
     8821 tgagaaaagc agagctattg tagatagatt ttattatctt ggagattggg aggatgagta
     8881 ttgtgattta acattagaga aaatgataaa tgattataag aaaaaaggaa gacaagacat
     8941 attaaaacat ataattacac ctaaatcatt agatgagtta aaaaaagaat tagattcttt
     9001 agaaaaaaat aatgatacat ataagcaagt tgccaatata aagccattac ctactacaaa
     9061 aaactctagt gtagaaccac ctaaattaaa tatatttaaa aaaataaaaa atagagtgtt
     9121 taaaaatgaa aagtaatgtt gatttaacag agaataggga ttttagagat gtaagaggaa
     9181 gaggcatcaa tattttaggt atcgaagatg cgccaaatag aatgttgagt tttagtgatt
     9241 ttggaattgg acgtctttat ggtaaaaatt tagaatttga atttaataaa aatgaagtat
     9301 ttttaactgg aaatgctaat gacagagaag aaaaaaagtt tcttatcctt tgtgaagaaa
     9361 ataaggtttg tgttagatgt ggtgatgaat taagagaggg gtgggataaa gtaagcatag
     9421 aactatgtaa tgaatgttat gaaatgttag atgttgagta taaaaataaa aagataatta
     9481 gagaattatt ttttagagat agagatgtaa atatagagtt actttaaaaa atatataaga
     9541 aaaataagta gaggaggaat ttatatgaaa gatgtttgat tatatagctg ggatgatgag
     9601 tgctttggaa gtgatgaata cgaaagtaga gaggaagcta ttcaaggagc taataaaact
     9661 agtattttta gtgatgacaa cagtatgaca agaataatga gaatataaag gagtgatgtt
     9721 tattaaaagt tttagatgta tattcagaca taagttttca aggataaaag attgtcaatt
     9781 aattacaaca aggagtcagc aatatacctg taaaatttgg atgtgtaaat attgtggaca
     9841 aattgtagct ggttcaactc ctgtttatca tcctaatatg aaagtcaatg agtattgtgt
     9901 aaagtgtgag ttttcggcat gtgcaaataa ttatgaggga tattgtaact ctaaagataa
     9961 agaaattgaa tttaagtcta tttgcttaaa aggtaataaa gagattttgc agtgtaaaaa
    10021 ttttgatttg gaataaaatt tagcttaagt aggagaattt tagaatatga aaataaatgt
    10081 acatgttaaa actaataaaa ttggttcaga ctgtgagctg gagtttgaaa tagatgatga
    10141 tgatttaaaa gatatgtctg atgaagagag agagggttat atagataaaa ttgcatggga
    10201 ttatgttttt gaaaatttta tagattggaa ttggtatgag gttgaagatt aagttaaaac
    10261 atttgtttta atgtgatttt acctagtaga tacaaggagg tttttaatga aagagctttt
    10321 agaagtaaaa aaaatatttg atagtttagc atctacatct agtagaaaag aaaaagagag
    10381 aatattagaa aaatataaaa ataatagaat gtttgttgaa tgtttacaat ttctactaga
    10441 ttcaaatatt ctcactggaa tatctaagaa taaaatatgt aagaatttaa ataatactgg
    10501 tcataatgaa ttagagaaca tatatgatat gcttgactat ttaattaaga ataatactgg
    10561 cagaaatata gatgtaaaaa caatacaagt atttgccagt aaagatgaaa aattaaaaga
    10621 ttttattttt aatttagcta caaaatcaat taaattagga ataacatata agactgtaga
    10681 caaaataatg ccaggtttaa ttatctaata aattttgtat tttttacaaa aaactattga
    10741 gaacatagag gttatatgat ataataaaaa tatattgaga acagagaagt taaaaagggg
    10801 ggcaatgaga tgactgacaa aataataata gcaagtgtag atggagagga aatgatattt
    10861 agaactgaaa tgaaaaagtt agaaaaagga gatagtctta tagtttctgt aaatggtgta
    10921 aaaagattag ctctattcat taggtatata agtacttgtg aagaatatat agaagatata
    10981 gcatttcaaa aagtagatga aatattatat gaaaacacaa ttgccaaaga aaaagaaaga
    11041 gttaaaaagg tatttaaaga taagtgtatg aaaaattata aacctattgt taatacagaa
    11101 atagactctt atttgagaga atgtggtttc aattgtgatg gtagacaatt tttcaaaagt
    11161 atagacaata cacaaatttt aattagcagg gattgtgata aagatgtttt gactgtatcg
    11221 aaaggtttga caataactaa aacagatata acaaataaaa atttaattac agttattaaa
    11281 ataataaata atagtctatt aatagttagg taatagaaat aaatattgaa cttttaataa
    11341 gaaaaaagat tttaaataaa aggagtgatt taatgaagaa tgttattaaa agagatggga
    11401 ggatagttcc ctttgatgaa aagaaaataa taaatgcaat agaaaaaagc tttttatcat
    11461 taaggaacaa aggaaaaagt gaagtatttg atagagaatt agcaacacta atagctaaaa
    11521 aaataaaaaa taaaccatgt gaaaaaatgc atatagaaga tatacaagat ataatcgaat
    11581 ttagcttaat ggctagtaaa aagaaagatg tcgctaaaga atatataaca tacagagaga
    11641 aaagaaatat agcaagagga agaaaaactt ataatgatta tatgtctatt gtaaatactg
    11701 aaagtaatga tataactaaa gaaaatgcaa atatgaacgc agatactcca gcaggtatga
    11761 tgatgaagtt tgcaagtgaa gctactaaaa cttttactga ccatgtactt ttatctgaag
    11821 aagcaaaaga agcaatgatg gataattata tacatataca tgataaagac tattatccta
    11881 cgaaatcatt gacttgtatc caacatcctt tagataaaat ttttaataat ggttttagag
    11941 cgggacatgg ctctagtaga cctactaaaa gaatagagac ttcaagtata ttaggatgta
    12001 ttagtttaga gactgtacaa aatgaaatgc atggaggaca ggcgatacca gcttttgatt
    12061 tttataatgc tccgagtgta agaaaaacat ttatagaaga aataaaaaat atagaaataa
    12121 aggatgatat tgatttatct catttataca atatagaaat agaggattat ataattaagg
    12181 acttaaaaga attagacagc gaaaaaagaa atgttcaaca tgctataaac agaactgtat
    12241 ggagagttca tcaatcaatg gagtcattta tacataatat gaacacaatt cattcaaggg
    12301 gtggaaatca ggtcgtgttt agttctataa attatggtac agatacttca gcagaaggta
    12361 gatgtataat aagagaaata ctaaaatcta cttatgaagg agtcggaaat ggagaaacac
    12421 caattttccc aattcaaatc tggaaagtga aagaaggtgt gaactataat cctactgata
    12481 gaaattatga cttatatgaa ttagcatgta aagtatcagc taaaagattt tttcctaatt
    12541 ttttaaattt agatgcaacc ttcaataagc atgtaaaatg gaaaatgtgc gacccaaaca
    12601 gatatattta tgaagtagca acaatggggt gtcgtacaag ggtatttgaa gatttgcatg
    12661 gagaaaaaac aagtatagga agaggaaatc tatcttttac gactcttaat ttagtaaaaa
    12721 tggcattaga ggctaaagaa aaatatccaa ataatgaagc taatagagtt gcagagttta
    12781 tttttcttct tgataaatat tcagatgtag tagcaagaca attatatgat agatacttat
    12841 ttcaatgtac tgctaaagca aaacagtttc cactattaat gagtgggtta tggaaaaact
    12901 cagaaaattt aaatccaaat gatgatgtaa gcgaagtttt aaagcatgga acacttgggg
    12961 taggatttat aggtctagca gaatgtttaa tagctcttat aggtgagcat catggtgaaa
    13021 gcgaaaaggc acaaaaatta ggtttagaaa tcatatcact tctaaagtct aaagtagaaa
    13081 aatataaaaa gaaatataac ctcaattatt ctgtattagg cacacccgca gaaggtcttt
    13141 ctggaaaatt tactcaaaaa gataaaaaaa tatttggaga aataaaaaat attacagaca
    13201 aagattatta tactaatagt tctcatgttc cagtttggta taactgcaat gttgaacata
    13261 aagcgaaaat agaagcacct taccatgaat tagaaggtgg tggccacata ttttatgttg
    13321 aattagatgg ggatgcaaca cataatccta aagctataat gaaagttgtg gatttaatga
    13381 aaaagtacaa tatgggatat ggttctgtaa atcatacaag aagtagatgt atgaattgtg
    13441 gttttgaaaa cgcagattca gagttaaaag aatgtcctaa atgtggcagc aatagtataa
    13501 atattatcca aagaattaca ggttatttag ttggaactac ggatagctgg aataatgcaa
    13561 aattagctga gttaaaggat agagtcacac atggataaag actatattta tattttagat
    13621 ataaaacatg acacaattgt tgatggagaa gggtttagaa catctattta ttgttctgga
    13681 tgtaatcata tgtgtagagg ctgccacaat cctcaatctt gggatataaa aaatggaact
    13741 ttaactaaag tattagatat ttataaggaa atcatttcaa ataaattttc agatgtaaca
    13801 ttttcaggag gagacccact tctacaactg caaggatttg ttcatttagc taaattaatt
    13861 aaaaagaata caaacaaaac aatatggtgt tatacaggtt ttaagtttga ggaactcata
    13921 acagacaatg aaaagctaga attgttaaaa ttaatagatg ttcttgtgga tggaaaattt
    13981 gaagaagata aaaaatcttt agagttgatt tttaaaggtt cgtcaaatca aaggataatt
    14041 gatgttcaaa aaacattgta tgaaaaacaa atagtattat atgaataaga gaggcttagc
    14101 cctctctttg gaggtaaatg ttatgaccaa agaagaattt attactaaat ttcttaaaga
    14161 gcagcagaga agaataaagg ttttatatta tgaagttgaa aatttcaaga tggatagaag
    14221 gtttaatgag aggaaaaagt ctaggagaca ttaaaatgtt tcttttaata taaggaggaa
    14281 gtagctatat gtattttgaa acggacatta taaaaaataa gaatactgta aataaaataa
    14341 taaaatattg tggtggaaat actgaaaaat tgaaagattg gctaaaagaa atagaaaata
    14401 aaagtatcag tagtttagaa gaattaaaag aatatccatt aaaaagaaat tataaatttg
    14461 tattttccaa agaagaagct cctaatttag ataagcttat aaaaatgaaa ctaagagata
    14521 attgtttaga aaaatgtgag atttgtagtt tagaaaatct cttaagtatg ctaaatgatg
    14581 agattttaga tttaaataaa gaagatatct cttatgaaga taatattgaa tggattgaaa
    14641 attgtaaaga agaactaatt aaattaaagg taggaagtat ttgcatagat tggtagaaaa
    14701 ataaaggagt gatattgtga gattttggtg tgagaattgt aataaatact tcaatgcgga
    14761 agaaacatta caggaatata attatttttt aaatgaagag atacttatat gccctagttg
    14821 caaaaaagat ttaataccta tagctaggga aacagaatta tcattaggtt ttgatagtga
    14881 tacaaaccaa ttaacttatg ttgaatatga ttctagtgat tatagtttac ttagaaaggt
    14941 aaatgcagat gttgaagatg tagtaaaacc tataatacat tacataagaa atttaaataa
    15001 aaatagttta gatttaaatg gaattacaga atagtgcgga aagcccactc ctttaggtgt
    15061 gggatggata gcacaaacag tgtataaaaa gtattgacac atacacgtat aatgttaata
    15121 ctttgtattc tgccctagat ataaaagaaa aatatttaat atagaaggtt tagaagatag
    15181 atttaaaaca ttagttaaaa ataagtgtaa ggaaatggat atcgaaattg ttgcaataga
    15241 atgcgataaa gaccatacac atatgttttt aaatagtctt ccgactctaa atccttctga
    15301 tataatgcaa aatataaaag gctatacaag taaaatatta agagaagaat ttattgaatt
    15361 atcaaaaatg cctagtttat ggactagaag ctattttgta tctacagcag gaaacgtatg
    15421 tagtgaaact attaaaaaat atgtgaaaaa ccagaaaaca agatactaga aagtgaggtg
    15481 aacactatgt caaattatat attaacattg caattaaaaa cagaaaagtt tcaagaagac
    15541 attatatgta atgcttttga taagtataga aaagtatata attcatgttt atcagagcta
    15601 tttaaaagat ataaccacat gatagaatct aaagaacacc aagcaaattg taaatataag
    15661 ggtaaagata gaaataaaat atttagtgaa attaataaga agtataattt aacagagtat
    15721 tcacttcata agtttgttaa atttattggt aaatattata aactacattc tgctataact
    15781 cagaagatag ctacaagatg ttttaatgct tttaataagt atatctatca tcaagctaaa
    15841 cgagttaatt atattagata taatgaatta acatcaatag aagggaaaca aaattcaact
    15901 ggtattagtt ataaagatgg tattattaaa tttaataaga tgactattcc agtaataata
    15961 aagaataatg acaattatgc tcaaagagcg atacaagata aaataaaata ttgtagaata
    16021 cttaaaaaag aaattaaggg taaaattaaa tggtatgtac aattagtctt agaaggaatt
    16081 ccacctaaaa aaacaaccaa tcaaggaaaa ataaaaggac aaattggttt aggtaatgta
    16141 ggtatagata ttggaactca aactatagct atatctagta aatgtgatgt taagttattg
    16201 gagttagccc ctaatgttaa taatatagat aggcaaataa agttaattca acgtaaaatg
    16261 gatagaagta aacgtgcaac taatcttaat aaattcaatg ataatggtac tataaaacaa
    16321 ggaaatagag ataagtggat atttagtaat cactatctta aattaaaaag actaagaaaa
    16381 gagttatata gaaaacaagc tgaaataaga aaacaagacc actatatatt aattaacaaa
    16441 ttactaaatt taggcaataa gttttatgtt gaaacgatga gttataaaag acttcaaact
    16501 agagtcaagg atactactat taatgaaaaa actggtagaa ttaataaaaa gaaacgtttt
    16561 ggaaaatcat tagcaaataa agcaccatca atgtttttga ctatgttaga caataagtta
    16621 aaatataata atgaaagatt atataagata gatactgcta aatgtagagc cagtcaatat
    16681 aatcactttt cagatgagta caataagaag gaattaaaag atagatggaa taatggtatg
    16741 gacattcaaa gagattgcta ttctgcattt ttaataatga atgttaatga agatttaaaa
    16801 tcaatcaaca gagaattgtg tgttaaaaca tatgataact ttaaaatatt acatgataaa
    16861 gagataaata gattaaaaaa attaaaatta aatggttata aattaatatc tagtatgggg
    16921 atataaaaac tatataggtt gagaaacgag cctaatatta atgttaatgg tgtcaacaga
    16981 tactttgtta ataaaagtct tagggaatat gattagtgat aatatgttgt aggttatgat
    17041 ttattataac tgagagtatt gtagaaattc atgtagtacc taagaacccc acgcctttag
    17101 gcgtaggagt ttcagaataa caatgaatgg taatatataa gaataaaaag aaggatatta
    17161 taagagatga gtcgatgtat gattatggga tgtctttgtc atctattatg aaggttatct
    17221 taaatcatca agaagatata gaaaagttaa aagaagagga ggtagcagaa tttataaaaa
    17281 ataaattaga aaatgagcat gattgtgatg aattaaaaat aataagtgag gtatttaatg
    17341 aaatatatta aacatgtaga taatggagta atgagagcaa taggtattga taattataaa
    17401 cctttattaa acatcataaa agaaaaagtg aatttagaat ctaattaaaa cagttttaat
    17461 tagcgaggtg atacatatgg gattagattt aggtttttat tcagtaaaaa caaaagttac
    17521 agatttagat atttatttaa ataaaacaag aggtgagaaa tataaggaat tgaataatga
    17581 tgaagaagag ttttataagt ttgaagaatt attagatatt gatatatctt tagaagattg
    17641 gtcagttatt cgtatgatat ataaagccaa atgggaaaaa ggttatgaaa gttatgaaga
    17701 tgaagccata cttattacaa aggaagattt ggaagattat ataattcctt ttcttaaaca
    17761 aaaagatata aattctaaga tatacaataa ggataaagag tattattata aaaatgataa
    17821 aaaagtaaca gttgatgata ggtatacaca ggagttttgg gatttagtat taaaagaatt
    17881 tcaaaaaatg ttaaacataa ttgattttga aaaacatagt ttaattatta tgtattggta
    17941 ttaagataat aattttaatt tatttggagg tttataataa tgaaaaaaat gtacatagca
    18001 attaattcag acttaaatat gagtccaggc aaagttggag cacaagttgc acatgcagtt
    18061 tatgattatt tgtataacaa aattttagac actgtttctt gctcttatga aacagaaata
    18121 atagcacatg aattaataga tttaaaatgt gatttaacgt catttaagaa taatggggat
    18181 acaatatgta tattaaaagc taaagaggca caattattaa aatttaaaga aaaaggttat
    18241 ttaactatag tggatagagg attaacagaa attcctaaaa atagcataac atgtgttaac
    18301 ttaggaatat ttaatgagga tgaaatacca tctacaatta aaagattgag attatattaa
    18361 ggagaaagac aataaatgta ttctaaaggt gatgtagtaa aagtatggtg ttatcaatgt
    18421 gaaaggatag aatttcaaga atttgtagga tattttaatt cttattttga taattataaa
    18481 ttaaagaaac gatggaaatg ctctaagtgt gatgtcatca ataattttta agagtttaat
    18541 taatggagga atgagttatg aaaataaaga aaataatttt aggattagat aacttagaga
    18601 atgtagagtt gggtattgga gatgtaggag gtttttattt agataatata catgaaatta
    18661 ttggaggatt tgctttgagt tatataggta aatgcaagaa ggcagattat ttacatatac
    18721 aaatacataa acgtgttgat gaaattcaaa gattgcatga ttataaggat attacaaatg
    18781 taaagataga atacgaagac ggaagtgtgg aggatatata tgtaccttat aaacaagaag
    18841 gggatttctt gggtttagat aatctttatc aaacttcttt tattagtaaa caaggttatt
    18901 tacatatagt tatctctaag gataaaacag tagaagaagt cttcaatgaa gaatttgagg
    18961 atgatgaagg ggtagaattt agttttaata tgtatggaat ataaaactta aaatggaagg
    19021 agatgagcaa atataattaa ctcttttaag aaattaataa agtcaaaata tataaaaaat
    19081 aacgaatcaa taaaaccatt agaaagaatt tttgaatatg aaataagaat caaagaaaaa
    19141 agaacatatt ttaatttaga attattgatt tatgaaaaaa gaattaagat aattaaaaaa
    19201 atatttttaa aagatatact atgccattat cgaagagata tagaacaact cgtcatttat
    19261 gacctggata aatatcttaa tatgacagat aaagaaatgg aggaatatat tataaattta
    19321 ataaaagata aaataaaaga agagtatggg gagaatatac ttcctgaaat actaatggaa
    19381 aaatttataa aactcgaaag aaaaggttcg gtgactgtag acgtacggga tttaatagag
    19441 ggataataaa taacaagtta aaatacaggt tttaaaagga gaataacaaa tggaagttca
    19501 agggaaatat aacaaagcta aaatatttac agagaatgta gattcgataa caataggaca
    19561 aataataaat ttatgtaatc aaaaggaatt taaagaatcc agtataagaa ttatgcctga
    19621 ttgtcatgct ggtaaaggat gtacaatagg aacaacaatg actataagtg ataaagtagt
    19681 accaaatctg gtaggggtgg atataggttg tggaatggct actattccat tagaaaaata
    19741 tattaataat ataaattata caaaattaga taagattata agagattata ttcctcatgg
    19801 atttaaaata cataataagt caagagaaaa actattaaag aatttattta atatagacat
    19861 aaataatctt agatgcgagg tgaataaaaa tagagcatat atgtcgttag gaactttagg
    19921 tggaggcaat cactttatag aagttgataa aagtgaaaaa ggtcaaatgt atcttactgt
    19981 tcatacaggt tcaagaaatt taggaaaaca aatagctgat tattaccaag acaaagctat
    20041 aaaatattgt attgaaaaat ataaaaagtc atatgatgat gcaaaagagt ttttaatatc
    20101 tactctaaaa aaagacaata aagaacattt gataaataaa tatttgaaag accttagtga
    20161 tagaaaattg aataagccac atgatgattt atgttattta gaaaatgatt taatggaaga
    20221 ttatttacat gatatgagta tagctcaaaa atacgctgct gcaaatagaa tggttataat
    20281 tgcggatata ttgtttaaat ataacagcct agaagtaaat tatgaccatt ttataagaga
    20341 tattaaatgt gatgttatag aatgtattca taactatata gatatggata gtaaaatact
    20401 tagaaaagga gcaatttctg caaataaaga tgaaacagta ataattccag taaacatgag
    20461 agatgggatt atattaggaa aaggtaaagg taattctgag tggaattatt cagcaccaca
    20521 tggagcagga agaattttat caagaggaaa agctaaagaa aaaatatctt tagatgaatt
    20581 tgaagagtct atgaaagaaa tatttacaac ttgtgtaggt caatcaacac tagatgaagc
    20641 accacaagca tacaaaccta tagaggatat cttaaacaat ataggagata ctattgagat
    20701 aatggaggtg ttaaagccaa tttataattt taaaagcaat tagaatcttg ttatttaaat
    20761 aaaatcaaaa ggagaaaaaa gggtatgata aaattaataa cacataatga tttagatggt
    20821 gtaagttgct gtattatagc aaagtatatt ttacgagaac aaatagatgt taactattgt
    20881 aattataaaa atataaatga tgtagtatta gatacattaa aaaatcacga taaatatgaa
    20941 caaatattaa taacagatat atcagtaaat gaagatgttg ccaagaagtt agataggatt
    21001 aaaaataaag ttcaattgct tgaccatcat ccaacagcac tatttttaaa taattatgat
    21061 tgggctaatg tagaaataga gtgtaataaa ggcaaaacat gtgggactca aatgttattt
    21121 aattatttac aaagatacta tgatgatact tcagaatcta cattaaaata ttttatagaa
    21181 cttgttagaa ggtatgatac atgggaatgg aaagataaat ataatgattt agatgccaaa
    21241 tatttaaatg atttaatgta tattatggga atagaggatt ttataatgga catgttaact
    21301 aaaatagata gtgatgagat gtgtctattt gataaattaa gtttaaaatt attagaaata
    21361 aaacaaaaag aaatagatag atatgtagag aaaaaagatg aaaatataat ggttaaagaa
    21421 attctaggat ataatgcagg aattgtattt gcagaaaatc atataagcga attaggaaat
    21481 aaattaagtg agttacatcc agaacttgat tttatagtta taattaatcg agaaatcatt
    21541 tcatatagaa ctataaaaga taatataaat ttaagtgaaa tcgctaaagt atttggaggt
    21601 ggaggaaatc cgaaagcatc aggaagtcag attgatgaga gttgtataga taattacata
    21661 aaagatatat ttaatataaa atcttaattt taaatggagg tatatatgaa atttgaaaac
    21721 aacatgatta aatacaattt agatttaata actatgatat gtaagatgaa actaataatt
    21781 tatgaggtgt aataatgatg atagataaat tcaattatga attatataat gagtttccac
    21841 atttatcacc aataatagaa ttgtataatt taaatataga gtacataaga gaagttgtaa
    21901 gtatacttat caatacagat atgacatttc aaaggtttaa atattccaaa tctagagttg
    21961 agtgttctat gaaagcgtat attatttcac ctaatagtaa gctaagtgtt gtatttgcat
    22021 acgattgtga attaaatgga attgacttag acaacctgaa ggcaattata tgagtataaa
    22081 caaataaaaa taatacttta caagaaaggt aaattgaata tgtgtaagtt ttgtgaaagt
    22141 ataattgata atacaaaaga tatactttta acctcaagaa gtagattatt agaagacaat
    22201 acatgtgaaa ttatagcaga agataattgt aataattgtt atgatggatg ttatgaatat
    22261 ttcaaactaa acggatataa aatcagggga aatacatatg ttaatgtcga ctactacaaa
    22321 aaaattagaa aaataataat tgctccatgt tcagaatcag tacatataaa ctattgtcca
    22381 tattgtggta aacaagtttc taaagatata aaagatttta attgtattcc tgagcatata
    22441 gtagatgtta gatataaaaa tggtgatgta tatgattatg atatggaaaa gtctgtacaa
    22501 gaagtcatgg ataatgcaaa taataattaa ataaaatgat acttttaata ggggataaat
    22561 atgaatcttt ggtctaaaat tgaagaacca gtgatgagag cagtaagtgg aatagtattt
    22621 aatatatggg gaaatgtttg tttttccata tattacatag aagaaaataa acaaatagag
    22681 ttagaaatat atgatagacc ttatagatat gaaggtaaaa aaaatagttg ttgagaagtt
    22741 atttgattac aagttaataa atgcagatta taaagaaata catgatattg tttctatgat
    22801 agaaagattt ttactagaaa attattaaaa ggagatattt aaaatgaata aaggaattaa
    22861 aaactatata acagcagtga attacttact tgataattta gagtatatga tggaggatga
    22921 cgaatttaat aatgaaaagt tacagaaaag aattgatgta attagaaaat ttgaaagaga
    22981 attataagat gggaaaaata aaaaatggag aaatagatac tgaagattat aggcttttta
    23041 aaaacattca aaaagaaaaa gatagagtat atagtaagta cattaatgaa gaatacataa
    23101 tggaagaatt cataaactac ttaagattgg aagataaaga ttatactaca gaaatattag
    23161 aaagatatgc acgatatatt gatgaaaatt tagacaatcg ttgtccatat tgtgtatata
    23221 atatttgtag tgaacatgat aattgttttg atggaatact tgaaaattta aaagaaaaaa
    23281 ttaaaataaa ataaatattt taatatgaaa ggatgttgtg ataataagta taagagaaat
    23341 tatggaaata gatatagaaa atctatcaat gaagcagcat gaagtgatta aaatatagaa
    23401 ttattaaaaa aatatgatac atatatatat aagaaggggc attatagaga aatgataaaa
    23461 gagagattta aagcaaaaga tagctttaat atggatgagt tcactaaaat ttggcttatg
    23521 gattttaaag aagattttga tttaagctta aagaaaatga tagaaaatac gataaaaaaa
    23581 tcaataaaag atacttatga agaaacagaa agggcgataa caaatataga aaatcttata
    23641 aataaactat aagtcaaaat attactaacg acacctctaa tataagatta gttatagagg
    23701 aaatctatta ttagagaagg catagattgc gtcactggaa caattcaagt taaaaactta
    23761 gataatcata tcaaataaaa tcttttacaa caaatcaaaa tttctaaaat aaattcttat
    23821 taataattca attaaaacta aaggagtgaa attatattga aaaagttttt attaacaggg
    23881 ttattaggaa caatgttaat agccatgtct ggatgtacag gaatacaaag ttcaatgaaa
    23941 gatgctgaaa gtgatgtatc agggcttaat agaactgtaa atgtatattc agataatggc
    24001 gaggtattaa aaacatatac aagtaaaagc atgagagtta aagatggaga tggtggtact
    24061 ataacactag attttgatgg taaaagggtg attatatgta atgctcatgt agtaatagaa
    24121 gaaaattcat ctaataaata aaggagagtt aaatgtttaa aattttaaaa acaattctta
    24181 taataatttg ggtagtagat attttaaact tcccacaatt tcaattctta gatacaacat
    24241 atccaatcaa taccttagca tggttgctaa tctggattct tataccatcg agtagtatat
    24301 atattgacaa aaaagaataa aagaaaggag tattaatttg attttaaata ttgctacaat
    24361 ttttaattta ggttgtatgg tggctaatta cttgcaagat aatactaatg ggatactact
    24421 taatggattt tgtcttatag cattattatt attgaataat gacttagatt aaaagtatta
    24481 ttttaaggag attaaaagat gaaaataaca atatcaattg aagaagcaat ggatattatt
    24541 aaacaacact atgagaataa aggaattgaa atcaaagact taagttttaa tttagaaaaa
    24601 actggaatgg ttagaaatat taaatttaag ggagaaataa tacttaagta ggagatattt
    24661 atatttgtta aaaaaaaggg gaagatattt ataagtagta caaatagaag tgatgctaga
    24721 agtttccata taagtgatta ttatagaact ccaattacta aaatcaaaga gtttttaact
    24781 gagttcagta gatatgaaaa tatactcaat tcaaatataa aaatattaga cccatgtgca
    24841 ggtggagata atacaaatcc aatgagctat ccaactgcaa tccaagaatt ttcaaatcaa
    24901 gaaatttcaa tagatacagt agatataaga gatgattcaa gagcaaatat aaagcaagat
    24961 tatttaaagt ttcagccaaa agaaaaatac gatgtaatta ttactaatcc tccctttaat
    25021 ttaagcttgg atataattaa taaagcttta aatgatgtaa gagaaggtgg tttcgttatt
    25081 atgctgctaa gattaaatta tcttggagga aaagtaagac aaaggctgtg gggaaataat
    25141 atgcctaaat acatatttgt tcacaataga agaatgagtt ttacagatga tggaaagaca
    25201 gatagcatag aatatgctca ttttgtatgg cagaaggggt ataatccaaa attttctcag
    25261 ttaaaagtat taataagtca atgaaataga ggtgtaaagt ttattagaga tggaaataaa
    25321 tagaagaaga tgtgagtatg ctgccagaac aggaagatat cctaattctc ttattttgtg
    25381 ggaaggttac tatagccttc ttaatatcca atatatagag gataaaacaa gaggatatat
    25441 tactaaattt aatggcatgg atgttataaa atgtaatgac tttttaaaaa tagaattatt
    25501 tgaaaagaat attaataatt aaaatttgtt ttttaagttg aggtgatgag ttgagatata
    25561 ataattatca tagtcataaa atttattcaa atataaggtc gttagatgta attactaaac
    25621 cacaacaata tatagataga gcaataaaac taggtcaaaa tacatatttt acgacagaac
    25681 atggatatca aggaaatgta tatgaggcaa aaactttatg tgatgaatat aaattaaaaa
    25741 tgattattgg agcagaattt tactatgtaa atgatataaa tgagaaagat agaggaaatt
    25801 atcatttaat agtaatcgct aaaaataatg atggttacaa gcaaataaat aaagctttaa
    25861 gtttagctaa taaaaatgga tattactata aaccaagaat agatgaaaaa atattatttg
    25921 agatatttaa accaggggat gtagttatta ctactgcatg tgtagctgga atattaaaac
    25981 ttgagaatag agaagaatta atactaaaac taaagaatta ttttaaaaat aatttctttc
    26041 ttgaagtaca atctcatcct cataaaactc aagctttgca caataaggat gttttagaat
    26101 taagcaacaa atataatata gatataatac acgccaatga cagtcattat atttatccag
    26161 aagaatcaaa atatagaact aaatttctta aagctaaagg tataaattat cctgaagaag
    26221 acggttttat tttagattat ccaaattcag aggatatatt taaaagatat gaaaaacaaa
    26281 atgtattaac aaagcaagaa gttgaaagag cattaaaaaa tactctaata tttgatgagt
    26341 gtgaagaaat caccttaata aatgatgata taaaattacc atcaatatct aaaaatccaa
    26401 ataaagaact gaaagaaata ttaaataaag aatggttaga gaaaagaaaa aatataccta
    26461 aaaatagatg gaatgaatac ttagatgcta taaggtatga atttgatatt atagagaaaa
    26521 ctcatatgga ggattacttt attatagatt ataaaatagt tcaaagagca aaacaagaat
    26581 ataatggtct tcttactaaa acagggagag gttcagcacc ttcatttata ataactaatc
    26641 ttttagggct tactgaaata gatagattaa atgctccagt accattattc cctactagat
    26701 ttatgagtgt tgaaagaata ctatcagcaa aatctttgcc agatatagat ttaaatgctg
    26761 aagatgctga accatttata caatcaacta gagatttatt aggagaagaa aattgtgcat
    26821 ggatgataag ttataagcca ttacaagatg cttcagcttt taggctatgg tgtaaagcaa
    26881 atgatatgaa actatctgag tatgatgaag tagctaaaaa cttagataaa tatacaaatg
    26941 atgttttttg gaaagatgta ataaaggaat caaaggtatt tgtaggagta gtagaaagtg
    27001 tttctttctc accatgctct atgcttatat atgatagacc aattgatgaa gaagtaggat
    27061 tattaaaaac taaggatggg gtatgttgta atatagatgg atattattgt gataagtata
    27121 aatatttaaa aaatgattat ttaacagtga aagtatggtc attaataaga aaaatttgtg
    27181 aattagcaaa tattagtatt cctacaattg aagaactaaa catcttatta gatgctaaaa
    27241 cctatgacat atataaggac aaattaactt gcactataaa tcaggtagat tcagactatg
    27301 ctacaaacct ggcatctaaa tacaaaatat ctagtgtggc ggaaacaagt gcatttgtag
    27361 ctagtatcag accaggattt gcatctttat tagacaattt tattaacaga gagtcatata
    27421 caactaacgt taaagaacta gatatattat tagaagatag ttatcattat cttatgtatc
    27481 aagaatcaat aatgaaatat ttaatatggt taggaataga ggaatctgag agttatgata
    27541 ttataaataa gattaaaaaa aagagattta aggaaaaaga gttgaaagaa ttgcatatca
    27601 aactaaaaaa taactggatt aaaaaagtcg gaactgaaaa taattttgaa gatacatggc
    27661 aagttgtaaa cgatgctgcc tcatattcct ttaatgcttc acatagtctt tcatatgcat
    27721 atgacagctt atactgtgca taccttaagt cacattatcc attggaatat tatactgtag
    27781 cattcaattt atataatgaa gatacagaga gaacaagaaa attaacagat gaaatagagt
    27841 attttagtat taaattagaa aatcctaaat ttagattttc aaaatctgaa tacttcttta
    27901 atagagacac aaatagtatt tacaagggca ttgaatctat taaattttta aattctgata
    27961 taggagagta tctatattct cttaaagata ataaatatga ttcattttta gagctattaa
    28021 tagatttgca ggggcatata aactctaaac aattatctat actgattaag ctagatttct
    28081 ttgaggaatt tggaaagtcc aacaaacttt tagagactta tgatatctat aactcaatct
    28141 atagtaaaaa acaatttaaa agagataatt taccatgcga tataaatacc atgagaaaat
    28201 actctaataa agaaacagaa aaaatattta aagaagttga tacaaaagaa ttatgttctt
    28261 atcttgaaag tcaaattgaa aatacagata taccaaccaa tgaaaaaata caagctcatt
    28321 ttgagtttgt gggttcatgt aacataaaag atagcaattc aaatccaagg tattgtttag
    28381 taatagatat agatactaaa tattctccta aagtcacatt gtataatata agttcaggaa
    28441 atataaagat tttcaaagta agtaaaccta tttttgagga taataaaatt gatgtttatg
    28501 atttagttta tttaaaatca attaaagaaa aagctaaaag taaaaaagta gatggaaaat
    28561 ggattaggag caatacagaa acagaatggt ggatacaaga atattggaaa atagaaaatt
    28621 aagaatatga cctcgtatat gcgtttctaa gagtttacat aagagtctgc ttgtatttat
    28681 acattgattt cttaaaatgg catatacgaa gttggtgaaa ggtagtgatt tcaatactta
    28741 tagatgaaca aagatattat agcttattgg aagaaaaaaa agacctaagt atgagaatcg
    28801 atgaattaaa agaggaaaat gcttttttaa aacaagaaaa tgaagagtat gaagaaattc
    28861 ttaatgagtg ggaatgtgta agaaaagaaa ttgtagcaac ttgtaaaaaa aaagaaatat
    28921 taggtgaaaa accaagtgaa ttagaaatgg ttcttcaaaa aatagaggat atataatgag
    28981 tgtaaataaa atttatgaga aaaaagaata cattattatc aaatcaaaat ctggatatat
    29041 agtttataat acaaataaag agtttaaaga aggccacact cacttaaaaa gttataatgc
    29101 tgctaaaaca gctatagatt tagttattaa gagaaggctt cctaaaagtt attctattta
    29161 ttttcttaca agtttgatga gaatatctaa tgatgtacaa tatataaaac atataagcga
    29221 tattgtatat ataagaaata ataaaggact aaaagaaaaa tatataaatt ctaaaaatat
    29281 taaaaaaaac tattgagaac atagaaggta tatgatatac tatgaatata acaagaacat
    29341 agaaggtaaa aaggaggtag tgattaatat ttgaaatctt ataaagaaaa acagttttta
    29401 gtatttgaat ttgaagatgg gaagaatgta aagtataatt tggcaacagg agaatacgtt
    29461 ggtaaatctg gaaggattgt aaaagatgtg tgtactcaac ttagaggata taatttacat
    29521 gaggtaataa attcttttga agatgaaaat tataagtgtt ttttaaattt tgtagatgga
    29581 agagtaaata gaagtaagag tagcagagct tggggaagga gggttgaaag aataagaaat
    29641 ataggaagtt ttttaaatga aataaataat tattctgagt atgaacaatt attctcagca
    29701 ggattaaaaa aaataattta tccgatacat tgtgatatta agagtatacc taaaggtctt
    29761 atttctatct gtaggaatta tagtattact ttgagtgacc gattgataca agggtatagt
    29821 aaaaacccaa atttgtataa taatttatta agtttagaat tgaattcaat aagaaaaact
    29881 aatttaattt caattcttga ttctggttat gatagaatga tatttgatag gttaatagac
    29941 atatataaat ataaacctca atcacttata aattatatag ataatctgat gacatatgaa
    30001 gcattaaatg ggcttgaaag cactctaaac gaattatatg actatgttgt tatgatgagt
    30061 gtaataagtg ataaatatga aaaatatcca agacatttct taacaactca taaaatagca
    30121 tctcgaaatt ataatcgtct taaaactcaa tttgaagaag aagtatttaa taaaagaata
    30181 gacaagtcac tagaatattc atatcaagat tataaattta tataccctaa aaatacaaat
    30241 gaaattaaag atgaagcagt acaacaaaat aattgtgtaa gtagttatat tcaaaatgtt
    30301 atagatggaa aatgtcatat attatttatg agaaaaaagg ataatccaag taaaagttta
    30361 gtaacaattg aagttagaaa tggcaaaata gtccaagcta aaggtaaata taatagagat
    30421 gtcaatgaaa gagagcaaga agcaattgat aaatataata atagaataga aaggatgaag
    30481 aaaatatgtt aatagaagga actaaaataa gattaatgaa agaaatacaa ggttttgaga
    30541 tgttaaaaat aggagatata tttgttatta catctgtggg aaacaatgga gctatacatt
    30601 tcaaaacaaa ttatgggatg ggattcatga attatagtga attaaaaaaa tattttgaag
    30661 ttgcaataga gactaagaaa aaagaacata tttggagcga atggagaact gcgactgtat
    30721 ttggaacaaa taaaacttgc acatatagaa caaatggaaa gaaagtagaa gttagaatgg
    30781 gagattttaa agcatcagct acttgccatg attcagatga gtttgaatta aataaaggtg
    30841 ttgagttatg tctggcaaga attgaagtta aaaaagcaaa taaacaggtg aatttagtat
    30901 tagataaaat aaataataaa gaaatttagg aggttagaat gagttgtaaa tttaaagaaa
    30961 gatgtgagaa taaaaataga gattgcgatt attgttgtta taatccaaat gcatatttag
    31021 aagatgcttt tgaatggaat ggagaaggga gaaagccaac agacgaagag ttagatgatg
    31081 ctcttgaaga ataaataagt atttaaaatt atcattttaa tatgattgga ggtctttatg
    31141 aggtggagaa atatattagt aacaagtgtt ttagtaatgg gtagtagcat acatatattt
    31201 gctaatacta aagaaatgag tactagcagg atggataaaa atattgtagc agatacagct
    31261 aaaaatatta acttaatgta taaatatgag tgggagcaac acaaaaatag ttctgaatat
    31321 aaattagaaa tcaagagaat taatttagaa aaggacttag gaataaaaat agaaaaattg
    31381 attcctgtaa catgggaagt aagttactat acttctttaa actgtgaaaa tagtaaatat
    31441 ggagctatta cagctacagg agaaaaatta caatatgggt ttgtggccaa taattatctt
    31501 aaattcggaa ctaaaatatt agtcgatgga aatttaaagg tggttaaaga tagaggttct
    31561 aataaatatt ttggtaattc taatgctata gatgtatttg taccaaaatt agagggggag
    31621 agtgattata aatattataa gagagtaaac aacatgggaa gacattataa agaaggatat
    31681 attatagttg aaggttagga gttgataaat tgaatgtaaa tggaataaaa ataccaggaa
    31741 ttattgatgt gtcaaatgtg tatgtttatg gaattaaaga aagcataatt gcaagtggtt
    31801 atccgatgta tgaacaacag gtaatagata tgaaaaaaat aaacatttca gaaaaagatt
    31861 taaaacgagc aaatcaatta ggcaaatcaa aacaaggttc aggtcatgat tgcttttcta
    31921 aaggaattat cattcaaatg gatttacaat ggtcagaata tatgtggaga caatgggaca
    31981 gatatcatca taatgattat gtgtctagtc aaagtaaaat gcatagatta tctaaattta
    32041 atcttgatga tatgtgtaat aaatatgttg ataaaaatac aataaatttt ctaaatgaat
    32101 taattcatga gtacaataac tttgaagaat tgaaattgaa taattctaat aatattattc
    32161 ttagaaatgg agaaaaagtt gaagtcacaa aagaaactct ttggaaaatc ataatatcaa
    32221 attgcccatc aggattgatg ctaactgcaa gagttacatt aaattatcta caaataaaat
    32281 ctatgataaa tcaaagagaa aatcataaaa tggaggaatg gagaattctg tgtgactttt
    32341 ttaaaacact accaaaatat aaagaattaa tgatgtaata gttttgttag caattaaatt
    32401 ttaaatataa aggagaagtg ggtatggcag aaaaaagaat aaattataat caagtatttg
    32461 tatcaggaga agttttagac attttaaata tagctagaat gaatcaagga actggccaag
    32521 aagctataag atttacctta aaggttgaaa cagcaccaaa cgaatcagta aatgtagatt
    32581 actttacatc aatgtttaag tcagatggtt caccaaatca aatgttttta ggaatagaga
    32641 caatagctaa tgaaataaaa actagagcag aagatggaaa aggtgatatt gttagatgtg
    32701 tttgttcatt agacaataac ttatattata aagatggtga aaagaaagag cgattccaaa
    32761 tatcaggaac tttttgcaat agagaaaaat atgatgacaa aggtaatcct attgatgaca
    32821 aaggcgaagt agtaaagtca ataaaagcga gtcaggtctg gagagtatat acattaattg
    32881 aaaatataga agaaaaagaa gatgatttag gtaagtattt agagattaag ggtttaatta
    32941 ataaatatgg taagcaaggt tgtaatatga catttagaat acataatgaa gatatgatag
    33001 aaggatttaa aagtttatat aaaataggag atgttggcct tcttgaaggt acagtaaaat
    33061 ctatggttgt tagtaaatca gcaggatttg gttcaagaat taaaaaaagt gcttttacat
    33121 ttttagaaat agaaggtggc gatgaacctt tgaaagatgg agacaaaata tttagtgata
    33181 aaaattatcc tttcacagat aagaatatag aggcaatgag agaaaaaata aaagaaaaag
    33241 ataaaaaaga aaaacaaaga gatattgata aaaatggtaa gacaattgag ataagagatg
    33301 atgatgtacc attttaaatt ataaattaaa taatctatta aaaaggagag atgtgaatgg
    33361 aagttaaaga aaaaacaatg aatgatggtt tcaagaaagt ggtaaatgag gaaataaaga
    33421 cgtatatatc aaatttatat tcagatagaa tagacggatt aaaagagagt gatagtcaaa
    33481 ttgagataac aaaagcatta atagcctttc atttagatat agaatcaatt ccaaaggata
    33541 atacaaaccc atttttcagg tctaaatatg caaaccttga tacaattctt aaagcagtaa
    33601 atccattatt agcaaaacat gatttaatac taatgcaatc agcagaagat gcaggtaatg
    33661 ataaagtata tataaaaact aaactaaagc attcatcagg cgaatacata gagtcaaatt
    33721 ctgcaccatt taaaccagct aaaactaatg atatacaagc tagaggagca ttggaaactt
    33781 atttgagaag atatgcagtt caatcagtat tagcattatc attcgaggaa gacgatgatg
    33841 gaaattcttt aacaaacaaa tcaaagggta aatcagaaga agaaaattca actattaaga
    33901 aaagtagagt gtaaataaaa ttgctacctc ttaaatgagg tagcaataaa tacataacat
    33961 aaggagggga aatcttgaat tgtaagtgta ggttttgtaa aaagaaatta aatacaaatg
    34021 atgcttataa agtagagcat attacatctg ggggaaataa gcagaataga tattattgca
    34081 atgaacagga atatagaaaa gagcaacagg atatatattt ctggaaacaa tgtcaacttg
    34141 gaatagatta tattatggga tatacagtta taaataatca aaaaaataag atgttacaag
    34201 agataataaa aggtggttat acgagagaag aattatatga ttgcatcatt gagaagaaag
    34261 atgaagttat agaattactt aactatagaa aagatataga agaagaatat cctaaattat
    34321 gttatgtgtt tacaatattg aaaggaagta ttagagatat aacaattaaa aacaagcaaa
    34381 tgaaatatga aaaagaaaat gaaaggatat acaaagaagt agagaaaagt gaagaatatt
    34441 atgaaataat tgctcctaaa aaagtaattt ataataaaag acaaagttta tttgacaaag
    34501 tgaaaggagt gtatcaagac gagtagttat gaaaaaataa tagaggatag gggtattata
    34561 gaaacattgg ttttaggcac aatgttaaaa tcattaactc tttttagtga atataaaatt
    34621 agcgaaagtg actttataat agataaggta aaattctttt tctcgttagg aagaataatg
    34681 tctaaaacac ataacgagct tgatgaaata agtgtagcta aatttgtatc ttcaaataaa
    34741 ctcaaatctg aatatgaaag atatggtggt tggaatagtt tatcatctgc tatggagtat
    34801 ggaaaagaaa ctaatatagc agcatatatt gatgatttag ctaagaataa tttactaatt
    34861 gctttagata aaagaggttt taatgtaata aaagaaatgg agcataatgg gttaaaattt
    34921 attccatttg aaatatttca atctatgaaa tgtagagaag tggaagaatt ttatgagggg
    34981 ttaatatctt catgtagtgt aaattctata aaaaataata tgaaagttga aaatctttta
    35041 cttactaaag atgatagaga aaaattaaag caaaaaactg aagcaggaac accttataat
    35101 attatatttg aatacactga aaaagaaata ggattgagta ataatgaaga atctaagtat
    35161 atatatagct taccaatatt atcaaatagg actaatggga ttggtaaggg tggtggtata
    35221 aatataatag cagggttttc aggcatagga aaaactactt tactattttt taattacata
    35281 ttagctatga tatatagagg agagaagata gtcatatttg cgaatgaaca aaaatctcaa
    35341 tattttaaga gtatgttagt atcgtttata gcatataaca tatttaatta tcatgattta
    35401 gatagaaata aaatagataa tggagatttt acagactttg aagaagactt aatggaaaaa
    35461 atagaaaaat ttttaagaga tagatgtttt gcagagaatc taaaatttat ctatatggaa
    35521 gaatttgaaa tatctgaaat actaaggaaa agtaaagaac ttgttacaca tcagggattt
    35581 actggaatag cagtggatac atttaaatca gaagattcgt cagatgcaca ttatacagga
    35641 aaattaattg aaaattctaa attactcgat agttttggga acaaatataa tgtaataact
    35701 atgttatcta tgcaattact tacagctcaa gaaaataaaa gctcatatct ttcggcagga
    35761 gatttgtcag aagcgaaagc tgtcaaaaat gtatgtggtt tattaaaact tatgagaaaa
    35821 gtagtaaatg agttagaatt agattctact aacaagaaat tctttttaaa accatataaa
    35881 ttaaaatata ataaattaaa aaagactact gaaagagaat atatccagtt tgatgcaaaa
    35941 gatttgcaaa aagaatatag attattattt ttaaataagt caagaagagg tcaagatgga
    36001 gatgtaattt tactaagatt ttatggtaag actggtagat tagaagagat aggaaggtgt
    36061 gagaaggtct acagaggaca attgtcatac taggtgatga ctatggaaat aaaggatttg
    36121 actaatgaac aggtgataaa ttttatggaa tatttaggtt cggacttatc tcctaaaagc
    36181 aatgatagac agttaatatt caatacttgt ttatgtcata atggtgattc atacaaatta
    36241 ttttattata cagaaagcaa aacgtttcat tgctatagtt cttgtggcca tataggtagc
    36301 ttaatagatt tattaataca cataaataaa tatgagttta aagatgctat taatgaaata
    36361 aaagatttct ttggtatttc aaatcaacca atgctaagaa aaggatttag aataaagaaa
    36421 aaagtagaac agatacatga tattaaagat atacaaatag aattacttcc tacccctaaa
    36481 aagccatatg tatataaaac ttttcagcaa gtcccaattg aagagtggga aaatgaaaac
    36541 atatcttttg aagtccttaa aacatatcaa gtatattata atctatatga aaatcaaata
    36601 gtaattccac atttctgttg gcatgataga gctaggcctg ttggtattag agttagaaac
    36661 ttagatgaag ataaggctaa aagttttggc aaatatattc cattatggta cgacaatagg
    36721 tgctataatc atagattaag tcttaatcta tatggattaa atgtaaataa aaaatctatc
    36781 aaaaattcca aaaaagttat tgtatttgaa ggtgaaaaat cggtgttaca aatggctact
    36841 atgtataaaa ataatccctc tgtagctata tgtgggagta attttagtag agagcaaaaa
    36901 aagatattaa tagatttagg tattgaagaa ttaatcatag cttttgatag acaatttaaa
    36961 gttaaagatg atgaagaata tgttatatgg agagataaga tatataaatt agttcaagat
    37021 attaaagatg tagtgaatat aagtgtaata tgggataaat ataatttatt gggctacaaa
    37081 gatagtccta gcgataaagg aaagacaata tttgaaaaac tattaaaaaa cagaattaat
    37141 atagagaact ttgttaaaca ataaaaaagt aaagaaatta attttatgag aaaattttta
    37201 ttgtttaggg atttattagc agatgctaaa taaaatatgt gttttaatat gaattggagg
    37261 tagattacat gataaaattt ttaataaaaa acgtacacat gggagataaa ttatattgta
    37321 taaataacat aggaaattat aaaaaaggtg aaatttatac agtgagtgat actagttttt
    37381 ttggactctt tcataaaact aaaggagaaa attgcttacc aattgaatgt tattttatac
    37441 acttaccaaa aaaagaagag ttagaaagta atcctaaatc aatgactaaa gaagaaattg
    37501 aagatgaact aggatataaa attaaaatag tttctaaata ataaagtgag gtgatattat
    37561 attgagtatc ttcaataaaa aatatggtag aaatgtaaaa ataacagaag aagaacctcc
    37621 ttctcctcct cccaaacaac caatatataa tagagataat atacaatatg ataaagaaat
    37681 ggaaagaaaa ctattagata ttgataggtt aaaaatagaa ttggaaaaag aaaaaaagat
    37741 agaagaagaa agaaaaaaag tagaaagagt aaaggaaaat gagggaaagg aatgggcttg
    37801 ggttgaagga tataaatgta cagataaaaa tatgaaatgt aaggaatttc aatatgaatt
    37861 aaacaaagcc tatagtatgg atggtgatga tattaatata tggaattggg gattccattt
    37921 atgtttagac ttgggtgacg tatttcaata ttatgctcca aatttaagca atagattttt
    37981 taaagtaaaa gctctagtga aaaaagccga taaatataaa tatggtaaag aatatggtga
    38041 agtgactctc ctttcaggta gtgttttacg tggtcataaa ataaataaaa tagctgctaa
    38101 agagataata tttttagaag aattaacttt tgataaatta aaactacata tacaaaatag
    38161 ttttcctgaa gtaaacacta agtctaaatg gtatgccata tgtaaattag gagaacaaga
    38221 atattatcat agaatgttta tgaatcaaat gaaaaagatt agattttcag atacattttc
    38281 tcaattatta tttgatgaat gtcgtaatta ttgtgaaata ttagaaatct taaataaagc
    38341 aatagcatat tcaaaagaaa atttatctaa agatatgata atatatttgc ttatgaaaga
    38401 tataagaaag taacatataa aaagaaggga gataatgtgg acaaaataaa taagatagat
    38461 ttgattaagt taaaagaaat gaatatatat gataattatc aattaaaaaa aatagcaagt
    38521 aaaatgatat tacatctaag atatgaaata atggactttt gtggttgtgg ttctcctgaa
    38581 gatatatctt ttatgataaa aggagtattg actgccatac aaaataaaga aaaaaattgt
    38641 aatttagaat acacagaaag atgttacata tttgaaatag aatttaataa tgtttgtgga
    38701 ataattggta gtaaaaatga tttgatacaa gaatttatat taaatgcttt aaattcatat
    38761 gggttattag aacatggtag tagcatttgg gggtcatggc tatctgatta tggtaaacaa
    38821 atattatgtg cttttgaaat agttggtgac tgtattttag atgttagcta tttagattaa
    38881 aaagttagtt ttaataggag gtggtaatta ttaaatatgt aatgagtgac ttacatggta
    38941 tgtatgataa atttatttca atgttagagc aaatcaattt caattcaaat gaccatttgt
    39001 atattttagg agatgtatta gatagagggg ataagtcttt agagattata gattatataa
    39061 gaaagtataa gaatataact cttctaaaag gtaatcatga gttaatgttt caagaaagtt
    39121 atacagatgt aaatagtagt tttctttggt tttataatgg aggtaaagat acattttatg
    39181 atttaggaat gaagtcttat gaatataaag aaaattttta taaatatatt aagaaccttc
    39241 catatttaga gataatagat aattttatac tagtccatgc tggactatac cttccaaata
    39301 actatgagaa tctcagtata gagcaaataa ttgagttaca agaagaagat atttgtgtgt
    39361 gggatagaac aatattaaat actaataaac atataaaagg atacacaatt attattggtc
    39421 atacaccaac tcaaaacatt aaagattatg aaaaggctga aatatataaa caggaaggaa
    39481 ttataaatat agattgtgga gcatgttttg ataatggtaa attggcttgt ttaagattgg
    39541 atgatatgaa agaattttat atttaagagg tgttatatgg acatattaaa aatcagttac
    39601 aacaatctaa atgctatatc aaaaatatca gaagtattaa gggatattgt aaatgaggac
    39661 actttaatag tatgtatagg tagtgataga gttttagctg actcattagc ccctatgatt
    39721 ggcagtatac tagaaaaatc tactattaga aataaaatat ttggagtatt aggagattca
    39781 atacatgctt taaatttaga acaaaaaata caagcaataa aaaataatta tccaaattca
    39841 aatataatag ccattgatgc ttgtataagt aaaatttcag ataaaggaac aattataatt
    39901 agcaataaac ctgttaaacc aggtttgggg gtagataaga agttactaga agttggtgat
    39961 tattcaatag ttgggattat aggtagaaat aaatatgata tatatgatac ttcagaccct
    40021 gaacttatac ttgatttagc tgatgttata tcgaaatctt taatatctat attattagaa
    40081 aaagaagaaa ggatgattgt atgatacagg aagtcagaca agaaatacta ttaaaaaatg
    40141 gtttgatttt atatacaggt gatttggtag aaataaaata caaatcagat gaagatgtaa
    40201 tagaacatac ttgtaaaggt aaaattaaag aagcaaaaga attatttatt aaattagata
    40261 caagtaagaa atataaaact tctgaaagaa tgatttattc ttgggaatta aaagaaataa
    40321 aaaaggtgga tgatgaagat gaaaaagata attaatagta aatatagagc attatattta
    40381 tttatatttt ttctaatttt caatttaata tatagtttat attttggaag gaatacggag
    40441 attggatttt attctagtac atcttgcata gaagaatata tactggatat tataacctct
    40501 ataggactat ttttctcaat gatgttagct gggtttgatg ttacagaaaa ctttataaac
    40561 agtttaaggg attattgtga agaagatgca aagtgaggtg aataaattgg aattaaagga
    40621 ttatataagt aaagtagaat taaatgacat gccattgacc ttagacaata aatacatgtt
    40681 aaatgaaata agcatatctg aagatagcaa aatctttgct gtaaaagaca catcaggaat
    40741 aacatcttat tatactgaaa tagaatttaa taaactattt agaggaatta atagcatcct
    40801 agagaatatt atctaatata tatttttaag gaactgaggg ttgagagcta ttaattaata
    40861 gctctctatt tttttgaaag gggagaatta atggaaaagg aactatacag ctttagtaaa
    40921 ttaaatgcat ttaacacatg tccatttcag tactatctta catatgtaaa aaatttaaat
    40981 cgagaacaaa gttgttacgg ttattatggc aatgaattac atagtttact agaacaatta
    41041 caacaaagaa aaataacaaa tcaagaagct attcaaaaat acaatgaagt tatagaatat
    41101 gcaaatctaa tggattacaa ttttcctaca ccaaattcaa gaattaatta tttagaatgt
    41161 atattacatt atatagaaaa ttttgtacca attgaatgtg atagatacta tatagaagaa
    41221 tattttgagt ttgatattaa tggaattaca atgaggggat atatagactt atattatata
    41281 ataggtaata aaatttatgt tatagattat aaatcgagta gtaaattttc taaaaaagac
    41341 ctacctaaaa aatcaatgca gcttatctta tatgcaatgt atcttaaaga aaaatatcca
    41401 gataaaataa ttgaatatgt agcttttgat atgtgtaaat atatgaataa tgaaaaagga
    41461 gtattaattg aaagaaataa gattgatagt ataaatgatt atgaaagagc tatagtaaaa
    41521 attaaatata ctaaagaact agagaaacaa ttaattgatt ttgttgttga tacagttact
    41581 caaataaaac agctagattc caacgatgag agcgtttggt gcaaaagtga tgacaaaagt
    41641 aatcagtttt tttgtaaaac tttatgctct cattataaca agggttgcaa acataaggaa
    41701 aacaagagtt ttagaaaatc aaaatcataa taaaatgtag attttaataa gattggagag
    41761 tgtttaaatg aatataccaa agcaagtaaa agtaggaggt ttattctata aaatagaaga
    41821 gacagaagaa cctattttag taaataatca attatgttat ggattagctg attatggaac
    41881 tgaaacaata aaattatcta ataatctaca atcagaaaga gtaaaagaag ctactttctt
    41941 acatgagtta ttccattgta tatttagaga tagatgtata gagagtgaag atgaggaata
    42001 tttagtagat gtattaagca agggacttca tcaagtgatt attgataatc ctaatatatt
    42061 tgaacttaag gtgagtatag atggataaat taaaaaatat atttgtattt ttaggttatt
    42121 ctggctcagg taaagatagt atagtaacag aaatttcaaa gcaattcaat attccaattc
    42181 taatatcaca tacaacaaga cctccccgta attacttaga aatcattaat aaaacctatt
    42241 attttgtaga taataaattc tttaagaaag aaaaaaataa ctttatagaa atgagaaagt
    42301 atatagttca tgatggcagc acttggctat atggtataca taaatctgaa ttagagaata
    42361 aaaaatatgc tttgactata gtagatgcaa gtggatataa agcactagaa aaatatttta
    42421 caggaacaaa aactaagtta gtaccatttt ttataaacgc agatgaagat actataagaa
    42481 aaagattaat agatagaggt gataatctta aagaaatcga aagaagatta gttgatgata
    42541 agattaaatt taaagagttt ttaaatagtg aaaactacat tgtaatagca aataacttaa
    42601 gtataactaa tgcagtagag caagttaaaa tacatatgaa agaggggatt caatggtctt
    42661 agccttagat gtatccatgt cctcaactgg atgggcagtt ataaatagaa ataagaatat
    42721 attaaaatat ggaaaaatag taactaaaaa agataaattc aagtctgaag atgagcgaat
    42781 gtgttatatc tgtaatgcaa ttcaagagtt aattataact cataatattc aaatagtctt
    42841 aattgaagac caattcactt caagaaactc taaaacaatt cttagtttaa gaaaactctt
    42901 aggagcaata atgaggactg taaaattaaa taatatagag attgaatata tgtatccagt
    42961 ttctattaga aaatatctcc tgaataatgg taaagctaaa aaggaagaag tagctgcata
    43021 tgtaagagaa aacattattg atattggaga atatattgat aggacttgta aggctaaaac
    43081 aagtgatata tatgatgcta tagcacttgg aatagcttat ttaaacaaac ttgatactaa
    43141 tagataattt taaaaaggga gattaaatta atgagtataa atgttaaaat aaagaaatta
    43201 aatcaaaatg caatagtgcc atcttatgca aaagaaggtg atagtggaat agatttatat
    43261 acactaaaag atacggtgat tccagctaaa tcagcagtag caatatctac aggtatatca
    43321 ttagaaattc catatggata tgaaatgcaa gtcagaccta gaagtggtat aagcttaaaa
    43381 ggaatgtttt ttacaagata tgtgactata tatgataaag tgcaacctaa aaaacaaatt
    43441 agaaaaattt ttgtagcaca tccaactgta agattaggta cagtggattc aggatataga
    43501 ggtgaaatta aaataattac atataatgaa gaggattttg atattttaat tcctaaacat
    43561 actaaacttg cacaaggagt atttcaacaa gttccaagag ctatattaaa agtggtagat
    43621 gaattgacta gctctgaaag aggaagtaat ggatttggaa gtacaggtat atagatgaat
    43681 aagtatataa tcctagaaaa atataattat tactatgatg acaaatgtat gacattatat
    43741 catttagaaa atatctatac aggattaaga ttttctattg aaaaaattga attagagtac
    43801 tataatatat cctagactaa ctttgggagg agtattaaat gtacagatat gatgattatg
    43861 taaatttaat aaatgactta gaattaccaa aagaaattag gaataaatgt gttagagtta
    43921 taatgacact agagaacatg caggatatta tggtagtaca taagtttaag acttatgttg
    43981 ttaatgaaaa atatattgaa aaagtagcat aaaataatta agtcatctat taatttaggt
    44041 gacttttttg catttatgtc gaatatttca tctacttcat attgtattag atgctataat
    44101 taaaatatat gtcgaaaggt agatggtgag gatgtttaag gagatatttg aaaaggtatt
    44161 tatgtcagaa gaagttagta aaactgtaaa agaagttaat aatattatta aggatactaa
    44221 gatacaagta aaaggtggat ttggagaact tagattagat tttatactta gcagattagg
    44281 caaagattac ataataatta aagacattat tgtaccaggc tcaaataaga ctacacaaat
    44341 tgatagtatt gtgatttcta tgtatggaat atttgttata gaatgtaaaa attttagtgg
    44401 atatatttac ggaaatgata aagataaagt atggactcaa attgtaggaa aaactaaaaa
    44461 tacattctat aatccggtaa gacaaaatta tgctcatatt aaagcaatag aaaatataat
    44521 aggaaataaa tataatatat attcaataat tgttttttca gacaaagcta cactaaaaaa
    44581 tgtaatgata agtggaaata atattatagt tataaatgaa agtgagatat taagtacaat
    44641 aagtaaatgt aaagatgtga ctattgataa agaagaaata aaaattatca gagataaaat
    44701 ttttgattgt atgaaaacca ctaatcaaaa tactagagag catgttagaa atttaaaaaa
    44761 tattactgaa gaggataagt gccctagatg tcaaattgga catttgatta aaagaaaagg
    44821 tcagtatggt gaattttggg gatgtagtca gtatccaaaa tgtaaataca ctagaaaata
    44881 aaaaacaacc tcttaaattc gattttaagg ctttgtaaaa attaatgctt ataattaatc
    44941 ctgttcggaa aatcgattgc ttaaaatgga aaatatataa aaataatagc gtgatagtgt
    45001 aaggcataga attgtgtatt ctatgtctta tttctttaca actaagtaat ttcaataatt
    45061 atataaataa aagaattaaa aaagtcagtt gaaagtcagc taaaatgact attttttgcc
    45121 tcctctgtat ggtataataa gtatatgaat tttgatagga gggatagtca tgaacgcttt
    45181 tataagaaaa agaaataaaa attatgtagt gtacttagaa tttagagatg atgaatcagg
    45241 aaaaagaaaa caaaaaaata tgggagcatt tgataaaaag agagatgcta ataaaagatt
    45301 ggctgaagtt aaggacagta tatataaaga tagttttctt gttccaaatg aaatcactct
    45361 agctggattt atattagact ttcttgaaaa atataaagat aatatttcgg catctacata
    45421 taaaagctat attgctattt gtaaaaatca tattaatcct tctattggaa aatatcgtct
    45481 tcaagagttg agaaatattc atatacagaa ttatatagat gatttagctg gtaacttaaa
    45541 tcctcaaact attaaagtac atataaatgt attgagactt gcaataaaga gagcgtatag
    45601 aattaagtta ataaaagaaa atattataga tggtatagaa agtccaagaa ttaaaaaatt
    45661 taaaaatgaa atttatgata aagagcagat gctaaaatta ttagagttag ctaaaggaac
    45721 taatatggag cttcctatta gtttagctat aggtctagga ttaagacttt cagaagtttt
    45781 gggattaact tgggataata ttgattttga tgaaaataca ataacagtaa ataagataac
    45841 tagtagatta gatggttctg ttatacttaa agagccaaag acagaaagct ctgttagaaa
    45901 aatatttgca ccaatagagc ttatgaattt actaaaaaat tataggctgg agcagaataa
    45961 gaaattattg agaagtattg ttagaaatga atataactta ctattttttg atagaaaagg
    46021 gaatccaatt gctgaagatg taatgagtaa gaaatttaga aaattcttag agaacaatga
    46081 tttacctcat attagatttc atgacttaag acattcacat gttactttac ttataaattc
    46141 caaagtacct ataaaggtta tatctgaaag ggtgggacat tcaaatatta atactactct
    46201 taatgtatat tctcatgtac ttaaagaaat ggacaaagaa gcttctgata gaatatctga
    46261 aaacttattt aaggctaatt aataattatt atcaataaat acaaaattaa taataaaagc
    46321 aaaggtataa acataaaggg gaatttttac aaagccttag aatggcatat agagcgtcag
    46381 attttagaag atattaaaat tttatatttc caatatttat gatataataa acatagcaag
    46441 gaataaatat ttgaaaaagc tgtgagtggt gtttccatag aaatttcctc actttcttat
    46501 gaaaggaggt gaaaaactat ggaaaatcta atgatgagta ttatagctgg tgttatagct
    46561 agttatatct acgataaatt aaaaagccac tcaaacgcga ctaagagtgg ctgggaactt
    46621 aatattaagt tccaaagaaa atccaaataa actaatttag tttggaaaca tcactcaaag
    46681 ttaagtaaaa tatgtttcct tgcttttatt ataccacaaa ttaagaatat taaaacaaaa
    46741 tttcatgtaa ataacattta atctgtaatt tttctatttt caaaaaaaac taactaaaag
    46801 ttgaaatata acaaatccaa ctgttgaacc taaagcattt ataggtactg atgttatatt
    46861 agtaaagtta tttaaagctg atatccctag cattactata gaaactatag ccaaataaga
    46921 gataactaaa aaaattggta ttgatatact tatattaatc tctaattcag gcaatttcat
    46981 aatatcattc ctttcaacat tcttatattt aaccttatta taccattaaa tataagaaat
    47041 cataatgtac aaaataactt atttttaatt acatactatg aaagagagtg cttttaatgg
    47101 ggtctatgtt ttatatatac tattccttaa aaatctattt aaagaatact atcatagaaa
    47161 catatcttgt tagattttga gttaaaagct acattatttg attcatttcc tatctgaaat
    47221 tatattgtat gtaaatcccc tgaaaattta tggttaaata catattcttg attatcaata
    47281 gtaactattt ctgtaaaatc ttttttagaa gcattataag tattgttttc agttagataa
    47341 gtattgtttg tctttgtaaa attaacactc ctatctatga atgataattc aacctaactt
    47401 aatcatattg ttgtcacaca acctaatgca attaatctac tctgtatttt tttatcttgt
    47461 tataccctct acttcaattc tattttaata gaattttatc atgtatagta acaattggca
    47521 atataaatt
//
LOCUS       DAEHWM010000021        46470 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.022, whole genome shotgun sequence.
ACCESSION   DAEHWM010000021 DAEHWM010000000
VERSION     DAEHWM010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 46470)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46470)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46470
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.022"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(63..150)
                     /locus_tag="KNP36_001262"
     tRNA            complement(63..150)
                     /locus_tag="KNP36_001262"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(114..116),aa:Leu,seq:caa)
     gene            302..2950
                     /gene="polA"
                     /locus_tag="KNP36_001263"
     CDS             302..2950
                     /gene="polA"
                     /locus_tag="KNP36_001263"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HBF0873147.1"
                     /translation="MEKKLIIIDGNSIINRAFYALPEMNNKEGLKTNAIYGFTTMLFK
                     MIDIYKPTHISVAFDRKAPTFRHLEYKEYKAGRKGMPDELAEQLQPLKDLLDKFRINR
                     LEIDGYEADDIIGTVSKKAEENGYKVYIVTGDKDAIQLASDNTTTLITKKGVGEVEEY
                     NFNSVIEKYEMTPTQFIDLKGLMGDKSDNIPGVPGIGEKTGIKLIKEFSSIENLIENT
                     DKLKGSVKKKIEENKEIAIQSKRLATIIRDVPIEVDLDSMIFGDYDKDELLDKFRYFG
                     FTSLLSRLVDLVDSDDTEHVEEKIEILKLKDIEKFIDEVNKKGQVILKTVRGQGNILE
                     KNIIYIFISVDGEKIYYVDSNEVSKLDSIFSNNEIKKYGYNLKDDYISLKPYNINLEN
                     MYFDITIAEYLIDSTSSTSYDCSAIAMKYLSKKVKSKEELLGKGVKSKNYEDLEFEDL
                     AEYMGQIICTVKETVPMMERSLMDMSMDGLFYHVEMPLVEVLGHMEYEGIKVDKSILD
                     ELSVEFKEIIATLEKEIYELSGEPFNINSPKQLGVILFEKLELPIIKKTKTGYSTNAD
                     VLEKLRDKHPIIDKITEYRQIVKLNSTYVEGLLNIINPESNRIHSSFNQTITTTGRIS
                     STEPNLQNIPIKMEMGRKIRKVFIADDNCKLVDADYSQVELRVLAHMSQDENMIEAFK
                     HHEDIHTKTASQVFNVPMEDVTSELRGAAKAVNFGIIYGKSDFGLADDLNIPVPKAKE
                     YIESYFAKYHKIKEFMDTTVEKASEDGYAVTILNRRRYIPEIKSSNFMERNRGKRFAM
                     NAPIQGSAADIIKIAMINVHKKLEENNLKSKLILQVHDELIVEAIDDEIDIVKKIVKE
                     EMENAVNMDVHLDVDLNVGSSWYETK"
     gene            2959..3561
                     /locus_tag="KNP36_001264"
     CDS             2959..3561
                     /locus_tag="KNP36_001264"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HBF0873148.1"
                     /translation="MLILGLTGGIGCGKSSLSNIFRNLNIPIVDADIISRKIFEDKLL
                     LEKVFVHFGQSIKNDDGTLNRKALGKIVFSDEEKLKELNNLTHPRIREKIISEIEKLR
                     KKGENIVVLDAAILVESGFLDMVDKLLVVTCKQEVQISRIQKRDNCSEQEALSRINSQ
                     MSQEEKSKYGDYIIDNSGTITELESKAHKFIEYMKENWRE"
     gene            3554..4108
                     /locus_tag="KNP36_001265"
     CDS             3554..4108
                     /locus_tag="KNP36_001265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing
                     protein"
                     /protein_id="HBF0873149.1"
                     /translation="MNSKKVLILSIFIILFGALLMESKVIHKFLYPKKYSEYVEKYSK
                     EFNLDENIVYSVIKAESKFNSSAVSKKEAKGLMQILDITRDWGAEELNLKNVDIFDPE
                     TNIRLGCWYLSKLYKEFGKLDLVIAAYNGGSGNVKKWLENNEYSKDGENLHDIPFKQT
                     SKYVEKVKNNYEHYNKIYGKKGKN"
     gene            4108..5823
                     /locus_tag="KNP36_001266"
     CDS             4108..5823
                     /locus_tag="KNP36_001266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0873150.1"
                     /translation="MKRIKVLTVVLAITLMVAGCSNTKTKQSSSDSSLQSQSSIDAKY
                     INLTMVTPKTINPITNTDKSVGYIMNLVYDSLFTIDENYNVIPQLVKEYNIAQDGMSI
                     DIKLKDAKWHDGKNVTSNDVNYTIGLIQKSADSPYNEFTKNIASVNIKSDKDFTIKFK
                     ARYAFSIDSLIFPIVSQNHLDSKDVNDKNNNMIGNGKYKIESYTEREGMVLSVNKDYY
                     EEVPKTMKNIKVGMVPNEDARTSMVMALDSDITNVTLNDLSKFQEKEFNITKYQGRDY
                     ECVLFNYNNPFFKDVNFRKAIAHSIDKDRIISEGYMDDATPVNFPLNSKSKYYNSEMK
                     DLEFNKDKAIECLAKVEYANVNSVNQNDNKVKNQKKSAKKNSKKLTPEEEAKVKKAEE
                     DRIKKEAEEKKNREKEEVKKSLSEMNLKIIVNRDNSERIKTANIINENLKAIGINSTV
                     NQLSDKDMENALNSKNYDLALVGWKLSIIPDASSIIASSGYTDDKLNGYMSALTSSTS
                     EIETKKAYKDVQTYIKDNATFISLAVRNNYIVSNSRLKGKITPNDFDVYEGISNLDIK
                     SNESN"
     gene            5896..6108
                     /locus_tag="KNP36_001267"
     CDS             5896..6108
                     /locus_tag="KNP36_001267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy-metal-associated domain-containing
                     protein"
                     /protein_id="HBF0873151.1"
                     /translation="MKKKLLVEGMSCGHCVNHLKTALTEDIDGIEVLDVDLENKCASV
                     DMKDDVSIEKLKEVIAELGFELKGIE"
     gene            6309..6908
                     /locus_tag="KNP36_001268"
     CDS             6309..6908
                     /locus_tag="KNP36_001268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873152.1"
                     /translation="MESRGYKEDLKKMILDMAHKELESYVSQKGAKKYFEGNLDKIIN
                     NNIKKFNQSIGLNRVYLKMLKKCAYQESVTSISRTIKKEALFKSKKELFAFSEYLKLD
                     INKRLSYNQILRKISRYIYYNRSSYAQKYVVFKRGDEEYLLEPEKIKDELISSYRSKT
                     REDMRSIAKLLDIEVEDDYNAEDIRKKVINYIIKEKLKS"
     gene            7136..7507
                     /locus_tag="KNP36_001269"
     CDS             7136..7507
                     /locus_tag="KNP36_001269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBF0873153.1"
                     /translation="MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILV
                     YLGDGITSHTLELTWLRDWDRPYNLGDNEFHLALEVEEFDEAKKLHKDLDCICFENES
                     MGIYFIADPDNYWIEILPKNH"
     gene            7639..8913
                     /locus_tag="KNP36_001270"
     CDS             7639..8913
                     /locus_tag="KNP36_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBF0873154.1"
                     /translation="MKKAIAALGIGAVAVSVSSINASALEKGTVTASALNIRSGPSSD
                     CDKVAKLYKGKTVEILEKSNGWYKVRVSSSVVGWGSAKYISTSGSSEGTSSQNNPTSS
                     GTTISGNGKVNVSSRLNVRSGAGTNYSLVGKANNGDVVKLLEQSNGWYKIKLSNGVTG
                     WASSQYISKTSEDVGTNNSSNSNSTNNSDKKPSSEESIEGKNGKVTSAVSLNVRSGPG
                     TSYSIIGKLNGGDVVELKAKSNGWYKVKLSSGTIGWVSASYISETNEDTKEKPNSSSN
                     QNSQSNSNSKPSFTGNSDKSTAKGSTIVDFAYTLIGIPYQWGASGPDKFDCSGFTQYV
                     FKHSVGVSIPRVSREQANFGSAISMGNYAPGDLVYFDTDGDGTTNHVGIYVGNSKFIH
                     CSGTQTNPNKVKVDNLTSSYWSKVLLGARRFV"
     gene            9024..9968
                     /locus_tag="KNP36_001271"
     CDS             9024..9968
                     /locus_tag="KNP36_001271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873155.1"
                     /translation="MNRRKTIYRGFNNNRHKIDLRKYVITIACLCLIGYYSYTKIKDS
                     KILEYVSAKIPFLNNSSDITYKDISDELNSIKKGKKSKSQTNSDDKQETNPEKAVNNT
                     KEPEEVKLATIEGWDMYTIQVAAIDNNDDLKKIQTSLVNNDIPFSVMEKDGVKKIQTY
                     SSFDENDVRKQISSVRKVFPDAFLSHLDAPMLSLEYTSNYAYIESISKELNKLITNFK
                     EESSFWSNAENNVDMEKYNTILTNRKAISQNISKEAEKIDYSEMRLFKDNLIEYVKNV
                     NEKIDTASKAANEEKYSVSKSLLLSSMQEYSMFINSIK"
     gene            10184..11521
                     /gene="rsxC"
                     /locus_tag="KNP36_001272"
     CDS             10184..11521
                     /gene="rsxC"
                     /locus_tag="KNP36_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit RsxC"
                     /protein_id="HBF0873156.1"
                     /translation="MKLLTFKGGIHPPYRKEYSNTKALEKAQAPKIVYIPLQQHIGAP
                     AKPIVEVGDEVKFGQKIGEQQGFVSCNVHSSVSGKVIAIEQHEVPGGSAQCVVIENDF
                     KEELHESVQPKGQLEDLSKEDIVGIIKEAGIVGMGGATFPNHVKVSPPPDSKAEVVIL
                     NGAECEPYLTADHRLMVENPEDVVFGLRALMKVLDVKKGFIGIETNKPDAIEAIQNVA
                     KDYSEIEVVGLQVKYPQGAEKQLIYACTGKEVPSGGLPIAAGAVVDNVATAAQIAKSI
                     KTGMPLVERITTITGSCIKEPKNLITKVGTLVSEIIEQCGGFKEDKKIGKVIMGGPMM
                     GIAQYTTEIATNKGSSGILCLDEEESRTPDIQNCLRCGRCTDVCPSFLQPLFISAYSL
                     KDDYDTAEYHRAMDCIECGSCSFICPARRPLLQSIRSAKREIGAKRRKQAAQK"
     gene            11544..12521
                     /locus_tag="KNP36_001273"
     CDS             11544..12521
                     /locus_tag="KNP36_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit D"
                     /protein_id="HBF0873157.1"
                     /translation="MENKLIVSSSPHVRSNEDTSYIMKQVIIALLPAAVAGVYFFRLN
                     ALSAMFFCILGTVGTEFLYQKFTKQKSTIGDFSAVVTGLLLAFNVPASLPWWMCLVGG
                     IFAILVVKMVFGGIGCNFVNPALAARAFLLASFPVAMTAWTQPGVNWIGKNLDAVTTA
                     TPLSFLKNGAAGLADLSSNGISLADMMIGNIGGCIGETSAILLLLGGVYLMYKGIINY
                     VIPVFYIATVFILTFLLGGFNITFAIYQLFAGGLMLGGFFMLTDYTTSPMTKKGQIIY
                     AVLAGLITTVIRMYGGYPEGVSYSILLVNCLAPLIDKFVRNRVFGEVAK"
     gene            12521..13090
                     /locus_tag="KNP36_001274"
     CDS             12521..13090
                     /locus_tag="KNP36_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit G"
                     /protein_id="HBF0873158.1"
                     /translation="MNSMVRLGGTLLAISAIAALALGATNQVTAPVIEQRNIQANNEL
                     RKAVLPEAKEFKEMKEDTYKGLGDGLIAEVYEGLDGSEVVGYTLKAKPSGYGGEIEVM
                     VGISSEGQVTGVDIGNMSETAGLGAKAKDDAFKGQYKGKTAEPLEVAKGSTTADNQIL
                     AISGATITSTAVTTGVNAAIDVFNSALNK"
     gene            13103..13696
                     /locus_tag="KNP36_001275"
     CDS             13103..13696
                     /locus_tag="KNP36_001275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit E"
                     /protein_id="HBF0873159.1"
                     /translation="MNLAKVFKNGLIDENPTFVQVIGMCPTLAVTTSAINGIGMGLST
                     AAVLICANLVISLIRKITPDKIRIPIFIVVIATFVTIVGMLLKAYVPALDKALGIYIP
                     LIVVNCLILARAESFAFKTGAMPSIVDGVGQGLGFTVALTIIGAVRELLGNGSLFGMT
                     LFGASFQPVLIFILPPGAFLTLGFLFAGFNKLRSKKA"
     gene            13711..14286
                     /gene="rsxA"
                     /locus_tag="KNP36_001276"
     CDS             13711..14286
                     /gene="rsxA"
                     /locus_tag="KNP36_001276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transport complex subunit RsxA"
                     /protein_id="HBF0873160.1"
                     /translation="MNLILLFLSIVLVNNVITSQFLGICPFLGVSKKVDTAVGMGVAV
                     TFVLTLASIITYFIQILLVKTGTGFLQTIAFILVIASIVQFVEMVIQKMSPSLYQALG
                     VYLPLITTNCAVLGIALVNVQKSYNLVETIINGFGAGAGFTLAIVIFAGIRERLELAD
                     IPEAFKGFPITLISAGLMSIAFLGFTGLIKL"
     gene            14302..15273
                     /locus_tag="KNP36_001277"
     CDS             14302..15273
                     /locus_tag="KNP36_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RnfABCDGE type electron transport complex
                     subunit B"
                     /protein_id="HBF0873161.1"
                     /translation="MVILTAVLVLGIMGLIFGIVLDFASKKFAVEVDERVEAILGVLP
                     GANCGGCGFPGCGGLANAIVEGNAPVNGCPVGGADVGAKVGEIMGISAEAGEKQVAKV
                     ICKGTCSSAKDKYEYEGISDCRAANVLNSGAKMCKFGCLGLGTCKDACKFDAISIVDG
                     IAVIDEEKCVNCGKCKEVCPKGIIITKPESQEVVVECNSKEFGKAVKEKCTAGCIGCG
                     MCVKACKFDAIIFEDKIAKIDPNKCVGCMQCVAKCPTKVISGDITKKKKVTIDQELCV
                     GCTVCKKQCKFDAIEGELKEKHKVDADKCVGCHLCMEKCPKKAIKIL"
     gene            15493..16077
                     /gene="maf"
                     /locus_tag="KNP36_001278"
     CDS             15493..16077
                     /gene="maf"
                     /locus_tag="KNP36_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation inhibitor Maf"
                     /protein_id="HBF0873162.1"
                     /translation="MNIILASASPRRKEILENTNVRFDIIKNEIDEIILEGETPKHLV
                     MRLAFEKSMSVASEHNEDVVIGADTVVVLDNAILGKPKDESCARDMLKRLSGREHQVI
                     TGISLINLCEDKKVIDYVISNVKFKTLSEQDIEDYLKTNESFDKAGAYGIQGYGALLV
                     EEIRGDYFNIVGLPISRLGDLLKKYFSINLFYGV"
     gene            16122..16781
                     /gene="radC"
                     /locus_tag="KNP36_001279"
     CDS             16122..16781
                     /gene="radC"
                     /locus_tag="KNP36_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HBF0873163.1"
                     /translation="MAPEERPREKMLAKGVKSLSNAELLAILLRTGNKNKNAIELANY
                     IINRDIQGIRHLEDMTIEELCNIDGIGLSKSTQIKAALELGSRVASFKPIKYKIRNPW
                     DIQRYYMDSLRYLKKEVFKAVLLNTKNEIISDVDVSIGTLSSSLVHPREVFKEAIRRS
                     ASKIIVMHNHPSGSVEPSREDKNITSRLIKCGEIIGIEIIDHIIIGDGLYFSFKENMI
                     I"
     gene            16902..17912
                     /locus_tag="KNP36_001280"
     CDS             16902..17912
                     /locus_tag="KNP36_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein"
                     /protein_id="HBF0873164.1"
                     /translation="MTKDMGIDLGTANTLVYIKGQGIVVREPSVVAIRDDSKEVLAVG
                     EEAKKMIGRTPGNIVAIRPMKDGVIADFDITQSMISYFIQKAADKKGVVSPRIAICVP
                     FGVTEVEKRAIEEAARQAGAKDAFLIEEPMAAAIGAGLKVEEPEGNMVVDIGGGTSEI
                     AVISLGGIVTAKSIRIGGDEFDESIVAYVKKEYNLMIGERTAENVKINIGSTFKDDEE
                     INMQIRGRDLISGLPKTIEICSTEVREALKEPVSSIVDAIKSTLERTPPELASDIMEN
                     GIMLTGGGALLRGLDKLITQETGMSVQIAETPLDCVALGTGKSVEDQEIFEKVLMMNT
                     KN"
     gene            17922..18815
                     /gene="mreC"
                     /locus_tag="KNP36_001281"
     CDS             17922..18815
                     /gene="mreC"
                     /locus_tag="KNP36_001281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HBF0873165.1"
                     /translation="MALRFDKNKNEKKRINVKVIATGVVAITLIGIVGISIGKFSSGS
                     PVNLGVASDAITSVGKGINDGFSFIKNGFKDVANFKDNSKKVKKLEEENEKLKKNMIA
                     LNAKLDKTESLEELKKTLNFVQEEYKATSISASVVGKNDGNWYESFVIGAGKNSGVKK
                     ESIVMNGSGLVGIVYEVSNNYSKAISLLDSKASVSFKLAKDANAKGTITQNTTLDNKD
                     SYNSKGYLQGYMFDSSYNVIQGDIITTSGLGFFPDGIPIGEVEKVVDDKDKSLKYVVV
                     KPYVDFKNINDVVVIEPRNIG"
     gene            18830..19318
                     /gene="mreD"
                     /locus_tag="KNP36_001282"
     CDS             18830..19318
                     /gene="mreD"
                     /locus_tag="KNP36_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HBF0873166.1"
                     /translation="MKKVLLCLLGIVLMTIENSITNYIDIFGISFNLVLIYVTIISLY
                     LDELEGGIIAAIIGLIKDITVGGIFGVNALILFIIAYAIGYMRDQLYKGSYIITFVLI
                     FIGSLIDSIVNIGTSSIIYQSYNISTLFVKGLLVAPIVNSLIGLVIYRLSKRAVLKLK
                     ED"
     gene            19330..22308
                     /locus_tag="KNP36_001283"
     CDS             19330..22308
                     /locus_tag="KNP36_001283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HBF0873167.1"
                     /translation="MEENKQVDRLKIIKIVMGVIFLAILVKIIYMTTFKYEYYNELAE
                     NKTYKKLAIEAPRGEIKDRYGRLLAGNKNLFTVQVSGNDINKKDANKHSRANEISLKL
                     INLLERNGEEYVDEFPIYVENGKYYYTYDRDIREYKSENGIPNDYNAKESFYYLVDKL
                     ISAGILSQEDKRLDATRLQAKLNENGYYPPILVSKWMFTAERDKRDWLASYKIKETKL
                     SAKEAFEKVRNSDALEIDKSLSDEDARKIMVVRDLIKSKGYSQYNPVTIAKDVGETTI
                     AQIEESAMDLVGVSIAVEPVRYYPNGSLASHMLGYVGKMPSTQIESYLQKGYETGDMV
                     GLAGVEKSNESRLRGTDGYKMVKVDALGRISKEIESKKPKSGDTVYLTLDKDLQEVSD
                     NALKQIIEVASKGGTFKSKFGDKPISAYAGKAQSAALIAIDVKNGEVLASSSYPNYDP
                     NKFAKGISTEDYKALQPKNPNDLLAGSPLLNLVTQGEFQPGSSFKMVTSMAALENGLD
                     PNFTINDPGVIMLGKKSFGDYVWNHGRGNHGMTNLYKAIQESCNIYMATIGTGKTWPD
                     GKSIGIDMNANKILEYAKLFGLDQNTGLQDEVEERAGKVPSTEDKLKSTQALLKSNLE
                     REMANDFVDITREKNPKEYEKRINEIVSWAAEKKTPGRVETMNRLKKLDVKEDRIEEV
                     ADLAVFSYFNFAKWSTADTFNLAIGQGENAYTPAQISRYVAAIANGGNLVELSVVDRA
                     VSSDYSSVKINDQKKVEKIPFKNPDNLKELTKGMKLVARQGTAKSAFADFPIDVAAKT
                     GTAEKSGKIPTDNEYEYLKSHMSSYNVNLNDAIKLADKMKAEKEKELSLAKEKEIKKK
                     LENKDLKDEERKKLEEELEDGVKVRLEDTDKVNSSYLRKAIKELNPKITDDQIDRFKQ
                     DYGSFTWTVAFAPADDPEIAVVCVIPQGDSSVFSLLPTREVIGTYMGLEPTNSKNDNK
                     TNDVNNSSDENINFESQINR"
     gene            22406..23089
                     /locus_tag="KNP36_001284"
     CDS             22406..23089
                     /locus_tag="KNP36_001284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum site-determining protein MinC"
                     /protein_id="HBF0873168.1"
                     /translation="MSLREICSQELVEFKGNKRGIIVNIKREAPFEEIQEKIINKLEA
                     YVGFFNGAKISKINSDCLTDMEILELKEGITSRFDVEFVEDQKIEENSNFPTKYVNTL
                     RSGENIEFEGDVVILNDMKPGSKVLSKSNTVVMGDINAGAKVVAGGNVFVMGKIEGFV
                     HAGAEGNEFAYVVAGNLNPKILQIADNIAEAPDDEENYESESEISPEIAFVSNGRIVI
                     ESYLSKLDK"
     gene            23113..23910
                     /gene="minD"
                     /locus_tag="KNP36_001285"
     CDS             23113..23910
                     /gene="minD"
                     /locus_tag="KNP36_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum site-determining protein MinD"
                     /protein_id="HBF0873169.1"
                     /translation="MSEVIVITSGKGGVGKTTTAANLGTALSLENKKTVVVDADIGLR
                     NLDVVMGLENRIVYDIVDVVEGTCRLKQALIKDKRFDNLYLLPAAQTRDKNAVSVEQM
                     IDLCEKLKESFEYIIIDCPAGIEQGFKNAVAGADRAIVVTNPEISAVRDADRIIGLLE
                     ANEIKEIRLVINRIRNDMVKRGDMMDKQDIIEILAIDLLGLVPDDESIIISTNKGEPA
                     ILDSKSLAGQAYKNIAKRILNEEVPLLDLEVEDGFFGRLKKMFSMAK"
     gene            23928..24212
                     /gene="minE"
                     /locus_tag="KNP36_001286"
     CDS             23928..24212
                     /gene="minE"
                     /locus_tag="KNP36_001286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division topological specificity factor
                     MinE"
                     /protein_id="HBF0873170.1"
                     /translation="MLDLFRVFSNEAKTSKSVAKERLKLVLVHDRVDCSPQLLEMIKT
                     DILKVIANYAEIEDDGLEIKMSKCRGEHDDKPVSALVANIPLKNIKDRCM"
     gene            24297..25427
                     /gene="rodA"
                     /locus_tag="KNP36_001287"
     CDS             24297..25427
                     /gene="rodA"
                     /locus_tag="KNP36_001287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein RodA"
                     /protein_id="HBF0873171.1"
                     /translation="MKKININYKSTIKLIKQLDWKLIVTVLAIFIFGLVILSSATHAN
                     STGSYNQLIKQGLAFVLGIGMIIVILFFDYNLLGRYYKALYIISLILLAIVLLPGIGT
                     VKGGARSWINLGPLDLQTSEIVKLTFVLSYAKILESKKDKLNTLKEVMPVVVYSLPFI
                     GLLIAQPDLGTGIVFCCMIFAMLFTAGLSSKLIKRGIIILLVSMPLMYLMMADHQKVR
                     IEAFLNPEDVTLKGNYQVMQSLIAIGSGGVTGKGLYNGSQNQEDFLPVQDSDFIFAVV
                     GEELGVIGMAVLIILFMIFLLRLLAIARDAKDFYGTLIVVGVMGMFGYQIIQNIGMTV
                     ALIPVTGVTLPFVSYGGSSLLTSLANLGLVLNVCMRRKKINF"
     gene            25468..25881
                     /locus_tag="KNP36_001288"
     CDS             25468..25881
                     /locus_tag="KNP36_001288"
                     /EC_number="4.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylglyoxal synthase"
                     /protein_id="HBF0873172.1"
                     /translation="MNIALVAHDQMKNTMVGFCIGYESILKKYGLYATGTTGKRIMDE
                     TELNINRLASGPLGGDQQIGSLIVTQEIDLVIFLRDPLTSQAHETDIQALIRLCDVYH
                     VPIATNLASAEIFIKALDRGELSWREVRKSKSQRI"
     gene            26366..26695
                     /locus_tag="KNP36_001289"
     CDS             26366..26695
                     /locus_tag="KNP36_001289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873173.1"
                     /translation="MQLNKEVLKGYIDILIVSILEKKDCYGYEIAKQVRERSEFELKE
                     GTMYLALKRMESKNLIKSYYSNEQSSGGRRKYYNLTNEGKDFLEIKKQEWRFIKKVMN
                     QFLGEVD"
     gene            26699..27490
                     /locus_tag="KNP36_001290"
     CDS             26699..27490
                     /locus_tag="KNP36_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873174.1"
                     /translation="MKLIDEYLDKLYKKCDNKSTIELKQEMRCHLIESANEFKLEGLD
                     EEEACKKAIERFDDGDEMQYELCNIIKELSLSLDRHKSIVMGFKKVLGYISIIAFLIS
                     GFMWYYNNSLQHNMYNLGKELDGEIKQLAERHDMTKIGEYKLELEKILDKDKYSKVKA
                     LRLYVIDMKDGNTNLSSSGLNANMVYEREADYNNISNFIQHLGYNGKDFLDKNGNIVN
                     PDIFLEYFFYFESEMLIPVAFVFGLLCIIAYFILRFKISLIKNNN"
     gene            27620..28440
                     /locus_tag="KNP36_001291"
                     /pseudo
     CDS             27620..28440
                     /locus_tag="KNP36_001291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428476.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
     gene            complement(28652..29845)
                     /locus_tag="KNP36_001292"
     CDS             complement(28652..29845)
                     /locus_tag="KNP36_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FprA family A-type flavoprotein"
                     /protein_id="HBF0873175.1"
                     /translation="MSKVFEVKKDIYFTGVVDEGLKVFDIIMETEFGTTYNSYLIKDE
                     KTVLFDTVKANFKDEFLSNLSEVTDIAKIDYVVIHHTEPDHAGSLKYLLDINPNIEVY
                     CTKAAKLYLDGQINRPFNCHVIKDGEILNIGKRNLRFITAPFLHWVDTMFTYIEEDKT
                     LLTCDAFGCHFASVDAEVVNSEDYLKSAKHYYDCIVKPFAKHVLSAVDKVVGLNIEFD
                     TILTSHGPMLTKDPMAAVKRYVEWSTEAVNTTNQNQVSIFYLSAYSNTLEMAKKIKEG
                     LDKEGAKAELYDLEDMTLTEMHDTLVVSKVILLGSPTINKTMVKPMWDLFSVIDPMAN
                     QGKIAGVFGSFGWSGEGITMAETLLKSMSFKMPVESLKKKFFPSEETLKECMAFGAEF
                     AKLVK"
     gene            30164..32008
                     /locus_tag="KNP36_001293"
     CDS             30164..32008
                     /locus_tag="KNP36_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03960 family B12-binding radical SAM
                     protein"
                     /protein_id="HBF0873176.1"
                     /translation="MNKVDLKKILKKVEKPARYLGNEINSIHKDTSNSELIRYAHCFP
                     DLYEVGMSHLGSHILYDVINKDEDVFCERVYSPAVDMENIMREKSIPLFALESREPIT
                     NFDFVTFTLQYELSYTNILNILDLANIPILKEERTLEDPFIMVGGPCAYNSEPLADFV
                     DVVILGEGEEVNLEVVNEYKEWKKNKTTREDFLYKISSIEGVYIPSFYDVKYNEDGTV
                     QSVTPNREGITKNPTKRIIKDVETVDYPEKLIVPYIDTVHDRIVLELFRGCTRGCRFC
                     QAGMIYRPIREKSVKRLKEILDKLVKNTGYDEISLSSLSTSDYSKLSELTDYLVDEYA
                     SNNIGISLPSLRLDNFSMEIADKIQQVRKSGLTFAPEAGTQRLRDVINKGVTEEDLEN
                     ATERAFEMGWNSVKLYFMIGLPTETYEDLDGIAKLAYKVIDIYRKVNGGKLKRSFSVT
                     VSTSTFVPKPFTPFQWHGQDTTEEVINKQRHLVNKLRNNNIKYNYHDSKTSLMEAVVA
                     RGDRRIGKVIYDAFRLGAKFDGWAEHFNLDIWKEAMEKNNLSIDFYAHRNRNYEEVFP
                     WDHIDVGISKKFLIREDENAKKEKITSDCRHNCNGCGINIHDIGRGLC"
     gene            32010..32711
                     /locus_tag="KNP36_001294"
     CDS             32010..32711
                     /locus_tag="KNP36_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2344 domain-containing protein"
                     /protein_id="HBF0873177.1"
                     /translation="MSKIIRVKFKKEGDMIYISHLDLQRLLQRAFRRAEINLSHSQGF
                     NPHPKMSYGNALALGAESQGEYVDIEIEEDDLSVEEFLNKVSIQLPDGIDFIKAKEID
                     RQTPSLSSVIDYGEYLFNIDLKRPMTKEFVKRKVIDFMNNKEIIITKKNKKGKMVEVD
                     IRPMIRTFDVLNLEDEHITLTATIATGSKTNLNTNILIPKILEMFELDIDPLDVDILR
                     RDLYVLEDGELVTPM"
     gene            32729..34150
                     /locus_tag="KNP36_001295"
     CDS             32729..34150
                     /locus_tag="KNP36_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rne/Rng family ribonuclease"
                     /protein_id="HBF0873178.1"
                     /translation="MKKIVIESLIGSQKTAVLEDERLTELFVEDNLNKKTVSNIYRGI
                     VKKVIPGIEACFVDIGFKKLAYLQLKKGSTIKSGQDILVQINKEEIGTKGAKLNTEIS
                     ISGRYIVYIPSNDRTTISNKITDEKERFRLKKITKAVNKENLGLIIRTEAQGCTHDEI
                     KKDIEELKLKYENILKEYKLGIGPKLLYKSLDFATKYVKDNVNDDIESIITNSYDKYS
                     ELKSILRGIDKTYVDKLCLEENRDVFDLYRIESKIEKLLNKKVWLKSGGYLIIEKTEA
                     LTVIDVNTGKFIGTGKLDETVYKTNLEAAKEIVRQLRIRDIAGIIIIDFIDMHKKKHQ
                     KEILHILEEEFNKDKRKAEVLGMTKLGLVEVARRREKESIDKYYLMSCPCCDGEQTIK
                     SVHYILDSIEKEIMRISEHTVYKNIMVEFNDFIFEQIKEYYMDIIDKIGEKYNIKISL
                     NANSTLKHNKTNVIFDKIVDNKM"
     gene            34251..34562
                     /gene="rplU"
                     /locus_tag="KNP36_001296"
     CDS             34251..34562
                     /gene="rplU"
                     /locus_tag="KNP36_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012063435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HBF0873179.1"
                     /translation="MYAIVKTGGKQYKVSEGDVLFVEKLEANAGDVVTLNEVLACSKD
                     GELKLGSPVVEGASVQAKVVEQGKAKKVIVFKYKAKKDYRRKQGHRQSYTKIVVEKIN
                     A"
     gene            34577..34894
                     /locus_tag="KNP36_001297"
     CDS             34577..34894
                     /locus_tag="KNP36_001297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HBF0873180.1"
                     /translation="MIKVKYYYNDDFLLQGFCLKGHADFAEIGYDIVCAAVTSNAIAV
                     INSLDKLQKIEFEKVVGEEGHIECIVKDTHVKDAQLLLNHFQLAVKEIKREYPKNIKI
                     LKK"
     gene            34908..35198
                     /gene="rpmA"
                     /locus_tag="KNP36_001298"
     CDS             34908..35198
                     /gene="rpmA"
                     /locus_tag="KNP36_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HBF0873181.1"
                     /translation="MLNMNLQLLASKKGVGSSKNGRDSISKRLGVKRFDGQLVTAGSI
                     IVRQRGTKIHPGTNVGKGSDDTLFALVDGTVKFERKDKKRKKVSIYPVAIAE"
     gene            35309..36586
                     /gene="obgE"
                     /locus_tag="KNP36_001299"
     CDS             35309..36586
                     /gene="obgE"
                     /locus_tag="KNP36_001299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000469293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HBF0873182.1"
                     /translation="MFIDKARIFVKAGNGGNGSVAFRREKYVPAGGPDGGDGGRGASI
                     IFEVDLGLRTLMDFKYQKKYQAQNGGDGSKGKRAGKNGENLVLKVPAGTVIRDEATGL
                     VLADLKKEGDTAIVAKGGIGGKGNQHFANAVRQAPAFAKSGTDGEERWITLELKMIAD
                     VGLLGFPNVGKSTFLSVVTKAKPKIANYHFTTLTPNLGVVQTKFGDSFVLADIPGIIE
                     GASEGIGLGHEFLRHVERTKVLIHIVDISGLEGRDPIEDFDKINDELKLYNEKLSKRP
                     QVVVANKFDILEDESKFEKFKSELEGRGYTVFKMSAATRQGIDEVIAYVSKMLKEVED
                     VELVSEEEMYRPELDIGTEEELSIDIEDGVYVVTGKALRRIMYSVNFDDMESLQYFQK
                     AMESQGVFDRLREMGIEDGDVVKIYELEFEFYN"
     gene            36638..37006
                     /locus_tag="KNP36_001300"
     CDS             36638..37006
                     /locus_tag="KNP36_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhbY family RNA-binding protein"
                     /protein_id="HBF0873183.1"
                     /translation="MLKGKQRAYLRSLANTLKPTTQIGKEGVTESFLEQLDGMLRTRE
                     LVKVTILENAGLDTKETANAVCEALRAEFVQAIGFKFTIYKRNIEEPKILFPGHEQAK
                     AKTKNNNVTKKGKPTKRAVR"
     regulatory      37098..37204
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            37307..38512
                     /locus_tag="KNP36_001301"
     CDS             37307..38512
                     /locus_tag="KNP36_001301"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HBF0873184.1"
                     /translation="MKIAILGYGTVGSGLIDLIENNTSKRDIEVVGILVKNKEKHKYK
                     KYFDKITTDIEDIFDKDIDILVEVIGGLNPAFDYVTRALNKKIHVVTANKDLLAEKGS
                     DLIELANLNNVSIKFEASVAGGIPVLKPLIESLEGNNIKSINAILNGTCNFILSKMYD
                     ENLPYDVALKQAQELGFAEVNPDADVLGYDSARKLSILSTLSYGKIVYWKDLLLEGIT
                     SIDEKDIEYAKKLNCKIKLVARSKYESGEVSGFVRPALVDNNNMLSKIDNEFNVVILV
                     GDSVGELSFVGKGAGRGATGSAVYADIIDIIDNRSSNIKSFSKGKLDLSGLIEDECSA
                     VVRFGGYNNKDGILECLDKYVDSYDIIDDEELAIFVSAKSEHEIDRVLEIVKRNNYSE
                     SAKKLLKID"
     gene            complement(38713..39279)
                     /locus_tag="KNP36_001302"
     CDS             complement(38713..39279)
                     /locus_tag="KNP36_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBF0873185.1"
                     /translation="MATRPIEIDEYKKIMELLHTGFTYSENGVEKRFRKNPKVALALM
                     LEANLGLRISDILRLKIGNFKGNMLEINEKKTGKLQYRPVNKNIIESINEHARKYNLK
                     SNDYLVNIKTKAIQKQLRIICKYLNLYNISTHSFRKLYATTQFEKSNNNLELVKELLN
                     HSSVATTQRYIRVTQQAINEASENFFIG"
     gene            complement(39559..40818)
                     /locus_tag="KNP36_001303"
     CDS             complement(39559..40818)
                     /locus_tag="KNP36_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YlbJ"
                     /protein_id="HBF0873186.1"
                     /translation="MKKNKIIAFFAPSIIVGVLVLGIILYPNEAIKSAREGFSIWSNV
                     LVPSLLPFIIGANLIVDLKIVDIIGFIINPITRFVFNVSGKSALAFAISTVSGYPVGV
                     SLASEFRSNGQISKYEAQRLVSFCSTSGPLFIIGSVGTGMFQNSNLGYLMILCHYLGT
                     ILVGLFFRNYGNENLPKTKLDLKTNIKNVINIRNSSGNGFFVLFGNAVFNGVNTLLTV
                     GGFVIVFSVVFKILSLFNVISLIASVIYLPLSFLGVSKELCQAFVSGLFEITIGCNKV
                     SSITSSPEILRASLASFLIGFSGLSILAQCCTFLSKTDIDLKLYILSKFAHGVLAAIF
                     IFILYPIANSAVLVSSFADTYNVIYNNLIWFYYLSYYDTILQIVVIIYLISAVFIAKK
                     HMKTLSTNGKLMRYKNTFFTKKFSRKK"
     gene            40943..41656
                     /locus_tag="KNP36_001304"
     CDS             40943..41656
                     /locus_tag="KNP36_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HBF0873187.1"
                     /translation="MFNSIASKKVYEQVIEQIQYKILNGELKKGDKLLSERELSEQMN
                     VSRTSIREAIRVLETMGVIESRQGEGNFICTNIEKTLIEPLSMIFKLNNGTLEDILEL
                     RIILEIEIAKLASKRITSSEVIELKHIIDEMRVETNKKDNNRVLVLLDQKFHSKLATL
                     SKNYLIQSLFMTASKLFDGFIEDAREKIIAEPFNENILLKQHEAIYNAVVENDVELAC
                     EKAKEHMDFISKNYRKNEN"
     gene            41774..43048
                     /gene="larA"
                     /locus_tag="KNP36_001305"
     CDS             41774..43048
                     /gene="larA"
                     /locus_tag="KNP36_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nickel-dependent lactate racemase"
                     /protein_id="HBF0873188.1"
                     /translation="MVKLKVPYSKQGMILEIPDERFLGVLESKSDNYIEHKTQEEIVE
                     ESMNNPIGSNSLEELVKGKKNVVIITSDHTRPVPSRITMPIILRRIRNVNPEIDVKII
                     VATGFHRPSTREELIYKMGEEIVDNEDIVMHISTDDKSMCKVGILPSGGDLYINKLAY
                     EAELLIAEGFIEPHFFAGFSGGRKSVLPGIASAKTIMYNHCSDFIDSDNSRTGKLNNN
                     PIHEDMVYAAKVAKLAFILNVVIDKDKKIIASFAGDVEKAHTKGCRFVTELSKVNSIK
                     SDIVVTTNGGYPLDQNIYQSVKGMTAAEATCKDGGVIIMISACNDGHGGQSFYENVAN
                     ADSPKQLLDKIRSVDRVDTIPDQWEFQILARILSKYTVIMVTDKCNPEMIKKMHMKHA
                     FNFKEALEMANSIVGKESKVVVIPDGVSVIVK"
     gene            43065..43853
                     /locus_tag="KNP36_001306"
     CDS             43065..43853
                     /locus_tag="KNP36_001306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003457975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBF0873189.1"
                     /translation="MEILTCIKQVPGTTSVEVDETTGVLKRDGVDSKMNPYDLYALET
                     ALRIKEDKKANLKVLSMGPPQAKKVIEESFMMGADEGALISDRRFGGADVLATSYTIS
                     QGIKKMGKVDLIICGKQTTDGDTAQVGPEVAEFLDIPHVTNVTKLIEVKDESIVVEID
                     MPNDLQVCEIEYPCLITVEKDIFQPRLPSFKLKLNTKDREIPVYSLDDFEDKDENNYG
                     LNGSPTQVVRIFPPKPNTDKNIVRGNADELSFALVNKLEELKLV"
     gene            43867..45087
                     /locus_tag="KNP36_001307"
     CDS             43867..45087
                     /locus_tag="KNP36_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding protein"
                     /protein_id="HBF0873190.1"
                     /translation="MSKIVVNQDKITDLKRILEICPFGAIEEKSGIVEISAGCKMCKL
                     CVKSGPKGAFEFIESSKVQINKDEWRGIAVYVEHHNGNIHPVTYELIGKAREMASKIK
                     QPVYCVFVGKDIKDKCSNLISYGVDEVFVYDEDEFKDFRIEPYSKAIENFIDKIKPTI
                     VLVGGTTLGRSLAPRLAARFRTGLTADCTILDIQSNTDLDQIRPAFGGNIMAHINTPN
                     NRPQFATVRYKIFSAPEKIENTTGKITLCKVEKKELKSKIKVLSVKEKNKEVGLEEAE
                     VIVVASRAIKKQEDMEMIYKLADKLNAQVAGTRPVIEAGWIDAKKQIGLSGRTVKPKL
                     IITCGVSGAVQFVAGMQGADYIVAINKDDKAPILDVAHLALIGDIYDIIPKLIEKIEN
                     NKDNNQKYMASAAK"
     gene            45098..>46470
                     /locus_tag="KNP36_001308"
     CDS             45098..>46470
                     /locus_tag="KNP36_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HBF0873191.1"
                     /translation="MYKLIDKKDIDFLIDTCGEENVLVGSDINEDFSHDELGGIEKYP
                     EVLVNVLETEQVSKIMKYAYKNNIPVTPRGQGTGLVGAAVAINGGIMINLCKMNKILE
                     VDYENLTLTVEPGVLLMTIGQYVQDRDLFYPPDPGEKSATIAGNINTNAGGMRAVKYG
                     VTRDYVRGLEVVLPNGEIINVGGKVVKNSSGYSIKDLLVGSEGTLGIVTKAILKLLPL
                     PKKSISLLIPFPDLSMAIETVPKIIKSKSIPTAIEFMERDVILAAEEFLGKKFPDNTS
                     DAYLLLTFDGNSTEDIEKEYEKVANLCLENGALDVFISDTQERNDSIWSARGAFLEAI
                     KASTTQMDECDVVVPRDKIAEFIRYTHELQDKLKIRIKSFGHAGDGNLHIYILKDGMD
                     DNTWKIRLKETFDYMYKKSRELSGQVSGEHGIGYAKKEYLHESNSDAYMMLIKNIKLA
                     FDPKNIL"
BASE COUNT        18342 a         5105 c         8789 g        14234 t
ORIGIN      
        1 aatttaaatc aaaaataaaa aaactcctaa tctattgaat aaatagcttt aggagttttt
       61 aatggtgccc gaggccggac tcgaaccggc acggagtatt agtccggtgg attttgagtc
      121 cactgcgtct accaattcca ccactcgggc atgtcatgta tattattata gcaaaaaaat
      181 atattgtttg caacatattt aattttaata tactattatt attatgggaa tattaaataa
      241 cagtatattg gtatataata tatatgttac aaaaatagat aatttttagg agtgatataa
      301 tttggaaaaa aaattaatta taatagatgg aaattcaata ataaatagag ctttttatgc
      361 tcttccagaa atgaataata aagaagggct aaagaccaat gcaatatatg gatttacaac
      421 aatgctattt aaaatgatag atatatataa accaacacat ataagtgtag catttgacag
      481 aaaagcacct acatttagac atttagaata taaagagtat aaggctggaa gaaagggaat
      541 gccagatgaa ctggcagaac aattacagcc attaaaagac cttttagata aatttagaat
      601 aaatagattg gaaatagatg gctatgaggc agatgatatt ataggtactg tttctaaaaa
      661 agcagaagaa aatggatata aggtatacat agtaactgga gacaaagatg ctattcaact
      721 tgcttcagac aatacaacta ctcttataac aaaaaaagga gttggagaag ttgaagaata
      781 caactttaat tctgtaattg aaaaatacga gatgactcca acacaattta tcgatttaaa
      841 gggtcttatg ggagacaagt ctgataatat acctggagta cctggaatag gtgaaaaaac
      901 aggtataaag cttataaaag agttttctag tatagagaat ctaatagaga atacagataa
      961 gcttaaaggt agtgtaaaaa agaaaataga ggaaaacaaa gaaatagcta ttcaaagtaa
     1021 aagacttgca acaattataa gagatgtgcc aatagaagtg gatttagata gtatgatttt
     1081 tggcgattat gataaagatg aacttttaga taaatttaga tactttggat ttacaagtct
     1141 cttatcaaga ttagttgatt tggtcgattc agatgacaca gaacacgtag aagaaaaaat
     1201 agaaatatta aaattaaaag atatagaaaa atttatagat gaagtaaaca aaaaaggaca
     1261 agttatttta aaaactgtta gaggacaagg taatatactt gaaaaaaata taatatatat
     1321 ttttataagt gtagatggag aaaaaatata ttatgtagat tcaaatgaag tgtcaaagtt
     1381 agatagtata ttttcaaata atgaaattaa aaagtatgga tataatttaa aagatgatta
     1441 tatatcttta aaaccatata atataaactt agaaaatatg tattttgata taacaatagc
     1501 tgagtactta atagattcaa cttcatctac ctcatatgat tgtagtgcaa tagctatgaa
     1561 gtatttatca aaaaaggtta aatcaaaaga agaattatta ggaaagggtg ttaaatctaa
     1621 aaactatgag gatttagaat ttgaggattt agcagagtat atgggtcaaa taatatgcac
     1681 agttaaagaa acagttccta tgatggaaag aagtctaatg gatatgagta tggatggtct
     1741 tttttatcat gtagagatgc ctttagtaga agtcttaggt catatggagt atgaaggtat
     1801 aaaagtagac aaaagtatat tggatgaatt gagtgttgaa tttaaagaaa taatagctac
     1861 attagaaaag gaaatttatg aattatcagg agagccattc aatataaatt caccaaaaca
     1921 attgggtgtt atattatttg aaaaattaga gcttccaata attaaaaaaa ctaaaactgg
     1981 atattcaact aatgcagatg ttttagaaaa attaagagat aagcatccaa taatagataa
     2041 gataactgag tatagacaaa tagtaaagtt aaattctact tacgttgaag gacttttaaa
     2101 tataataaat ccagaaagta atagaataca ttcatcattt aatcaaacta taacgactac
     2161 aggaagaatt tcatctacag aaccaaatct tcaaaatata cctataaaaa tggaaatggg
     2221 tagaaaaata agaaaagtgt ttattgcaga tgataactgt aagttggttg atgccgatta
     2281 ctcacaagta gagctaagag ttcttgcaca tatgagtcag gatgaaaata tgatagaagc
     2341 atttaaacat catgaagata ttcataccaa aacagcttca caagttttta atgttcctat
     2401 ggaagatgtt actagtgaat tgagaggtgc agctaaagct gtaaactttg gtattatata
     2461 tggtaaaagt gactttggtc tagctgatga tttaaatata cctgttccaa aggcgaaaga
     2521 atatatcgaa agttattttg ctaaatacca taaaataaaa gagtttatgg acacaacagt
     2581 agaaaaggct agtgaggatg gatatgctgt aacaatttta aacagaagaa gatatatacc
     2641 agaaataaag tcaagcaatt ttatggaaag aaatagagga aagagatttg caatgaatgc
     2701 accaatacaa ggaagtgcag cagatataat aaaaattgct atgataaatg ttcataaaaa
     2761 attggaagag aacaatttga aatcaaaact tatactacaa gttcacgacg agttgatagt
     2821 tgaagcaatt gatgatgaaa tagatatagt taagaaaata gtaaaagaag aaatggaaaa
     2881 tgctgtaaat atggatgttc acttagatgt agatttaaat gtaggtagtt cttggtatga
     2941 gacaaagtag gtgattttat gttgatatta ggacttacag gaggaatagg ctgtggaaaa
     3001 agcagcctat caaatatatt tagaaatctt aacattccta tagtggatgc tgatattata
     3061 tccaggaaga tatttgagga taagttgtta ttggaaaaag tatttgtcca ttttgggcaa
     3121 agtataaaaa atgatgatgg aactctaaat agaaaagctc ttgggaaaat agtttttagt
     3181 gatgaagaaa aacttaagga attaaataac ttgactcatc cacgaataag agaaaaaata
     3241 ataagtgaaa tagaaaaatt gagaaaaaaa ggcgaaaata tagtagtgtt agatgcggca
     3301 atattggtag aaagtggttt tttagatatg gttgacaagc tattagtagt tacttgtaaa
     3361 caagaagtac aaattagtag aatacaaaag agagataatt gcagtgagca ggaagcactt
     3421 agtaggataa attcacagat gagtcaggaa gaaaaatcca aatatggtga ttatataata
     3481 gataattcgg gaacaataac tgaattagaa agtaaagcac ataaatttat tgagtacatg
     3541 aaggagaatt ggcgtgaata gtaagaaagt attgattcta tctattttta taatcttatt
     3601 tggggcacta ttaatggaaa gcaaagtaat acataaattt ttatatccta aaaaatattc
     3661 agagtatgta gaaaagtatt cgaaagaatt taatttagat gaaaatatag tttacagtgt
     3721 tattaaagcc gaaagtaagt ttaatagttc tgctgtttca aaaaaggaag caaaaggatt
     3781 aatgcaaata ttagacataa ctagagattg gggagcagag gaactaaatt taaaaaatgt
     3841 ggatattttc gacccagaga ctaatataag acttggctgt tggtatttaa gtaagttata
     3901 caaagaattt ggtaaattag atttagtgat agctgcatat aatggtggtt caggtaatgt
     3961 gaaaaaatgg ttagaaaata atgaatatag taaagatggc gaaaatctac atgatatacc
     4021 ttttaagcaa acttcaaaat atgtagaaaa agtaaaaaat aattacgaac attataataa
     4081 gatatatggc aagaaaggaa aaaactaatg aagagaataa aagtcttaac agtcgtttta
     4141 gctataactc ttatggtagc tggttgtagt aatactaaaa caaaacaaag tagtagtgat
     4201 tcaagtttac aaagtcaaag ttctatagat gctaagtata taaacttaac aatggtaact
     4261 ccaaaaacta taaatcctat aactaatact gataagtctg ttggttatat aatgaattta
     4321 gtttatgata gtttatttac tatagatgag aactacaatg taattcctca attagttaag
     4381 gagtataata tagctcagga tggaatgagt atagatataa agctaaaaga tgcaaagtgg
     4441 catgatggaa aaaatgttac ttcaaatgat gtaaactata ctattggttt aattcaaaaa
     4501 agtgcagata gtccatataa tgaatttact aaaaatatag cttctgtgaa tattaaatca
     4561 gataaagatt ttacaataaa atttaaagct agatatgctt tttcaattga tagtttaatt
     4621 tttccaattg tatctcaaaa tcatttagat tcaaaagatg taaatgacaa gaataataat
     4681 atgataggaa atgggaaata taaaatagaa tcatatacag aaagagaagg aatggtttta
     4741 tctgtaaaca aagattacta tgaagaagtt ccaaaaacca tgaagaacat aaaagtaggt
     4801 atggtgccta atgaagatgc aaggacatct atggttatgg ctcttgatag tgatataacc
     4861 aatgttacat taaatgattt aagtaagttt caagaaaaag agtttaatat aacaaaatat
     4921 caaggaagag attatgagtg tgtattattt aattataata atcctttttt caaagatgtt
     4981 aattttagaa aagcaattgc acactctata gataaagata gaattattag tgaaggttat
     5041 atggatgatg ctactccagt taattttcca cttaattcaa aatcaaaata ctataatagt
     5101 gaaatgaagg atttagagtt taataaagat aaggcgatag agtgtcttgc taaggtagaa
     5161 tatgcaaatg taaactcagt aaatcaaaat gacaataaag taaaaaatca gaaaaaatca
     5221 gctaaaaaga actcaaagaa gcttacgcca gaagaagaag caaaagttaa aaaagcagaa
     5281 gaagatagaa tcaaaaaaga agctgaagag aaaaaaaata gagaaaaaga ggaagtaaag
     5341 aaaagtcttt ctgaaatgaa cttaaagata atagtaaaca gagataatag tgagagaata
     5401 aaaactgcaa acataataaa tgaaaactta aaagctatag gaataaatag tacagtaaat
     5461 cagctctcag ataaggatat ggaaaatgct cttaattcta aaaattatga tttagcatta
     5521 gttggatgga aactatcaat tataccagat gcaagtagta ttatagcgag tagtggatat
     5581 actgatgata agttaaatgg atatatgtct gcacttacaa gttctacgtc tgaaattgaa
     5641 acaaaaaaag catacaaaga tgtacagaca tatataaaag ataatgcaac atttataagt
     5701 ttagctgtga gaaacaacta tattgtaagt aatagtagat taaaaggtaa aattactcca
     5761 aatgattttg atgtatatga gggaatatct aatttagata taaaatcgaa tgaatcaaat
     5821 taaatgatta atttctattt aaaaagtata aactatatga tagaataccc ttatagggta
     5881 taaggaggta attaaatgaa gaagaaacta ttagtagaag gtatgagttg tggtcattgt
     5941 gtaaaccatc ttaaaactgc attaacagaa gatatagatg gtattgaagt tttagatgta
     6001 gatttagaaa ataagtgtgc atctgtagat atgaaagatg atgtatctat tgaaaaatta
     6061 aaagaagtga tagcagaatt aggatttgaa ctaaagggaa ttgaatagaa attgataaac
     6121 taaaaaaaga cctctattgg gggagtaata gaggtctaaa aatgggggag attgagtatg
     6181 tttgatttta cattactatt atctcccctt ttaaattaat atatacataa aaagtaaaaa
     6241 aattttgtaa tgactcacat ttcttgagct ttttgaatat actataaata gctaagggag
     6301 ggagtatcat ggaatctagg ggatataaag aggatttaaa aaaaatgata cttgatatgg
     6361 cccacaaaga acttgagagt tatgtatcac aaaaaggagc aaaaaaatac tttgaaggta
     6421 acttggataa gattattaat aataatataa aaaaattcaa tcaaagtatt ggtcttaata
     6481 gagtatattt aaaaatgtta aaaaagtgtg catatcaaga aagtgtaact tcaatatcaa
     6541 gaactataaa gaaagaagca ttatttaaat caaaaaaaga gctatttgct ttttcagagt
     6601 acttaaaact tgatattaac aagcgacttt catataatca aattttaaga aaaatatcaa
     6661 gatatatata ctacaataga agttcatatg ctcaaaaata cgttgttttc aaaagaggag
     6721 atgaagaata tcttttagaa ccagagaaaa taaaagatga attaatatca agctataggt
     6781 caaagactag agaagatatg aggtcaatag caaaactttt ggatatagaa gtagaagatg
     6841 attataatgc tgaagatatt agaaaaaaag taataaatta tattattaaa gaaaaactta
     6901 aaagttagag ttttaaagaa taagttctgc caatttgcat gattaagtat aacttgggta
     6961 taaatttttt atgcatttga aagagcttat tctttttttg acatattctt ttaaataatt
     7021 taccatgatt tggtaattgg tcatcatcat tcaaattttt aacttaatat gatttaaata
     7081 aatttataat aatgatataa tataaaaaaa ataaaaattg gagagtgatt tcaaaatgaa
     7141 gtttaatttt tgtcataaca atttcaatgt tactaattta gaaaaaagtt tagattttta
     7201 taaaaaagct ttagggctta aagaggtaaa gcgcaaggaa gcagaagatg gaagttttat
     7261 attagtttat ttaggagatg gcattactag tcatacatta gaattaactt ggcttagaga
     7321 ttgggataga ccatataatt taggagacaa tgaatttcat ctggctttag aagttgagga
     7381 gtttgatgag gcaaaaaaac ttcataaaga tttagattgc atatgttttg aaaatgaaag
     7441 tatgggaatt tattttatag cggacccaga taattattgg attgaaatac ttcctaaaaa
     7501 tcactaattt taaggatatg tttataattt ctttacaatt aataagaaaa taagttatca
     7561 ttaaattgta gggactaaaa atggataata atgttatgaa tttatgacta taaaaatttg
     7621 ttggggggag tgatagtagt gaaaaaagct atagcagctt taggaattgg ggcagtagca
     7681 gtatctgtta gctccataaa tgcaagtgct cttgaaaagg gaacagtaac agcaagtgcc
     7741 ttgaatataa gaagtggacc aagttctgat tgcgataagg tagcaaaatt atacaaggga
     7801 aaaactgtag agattttaga aaagtctaat ggatggtata aagtaagggt atcgagttct
     7861 gttgttggat ggggaagtgc aaaatacata tcaacaagtg gttcgtctga aggtacatca
     7921 agtcaaaata atccaacttc aagtgggaca actattagtg gaaatggtaa agtaaatgtg
     7981 agttctagac tgaatgtaag aagtggtgca ggtactaact attcattagt tggtaaagca
     8041 aataatggag atgtagtaaa gttactagaa caaagcaatg gatggtataa aataaaacta
     8101 tcaaatggag ttactggatg ggctagtagc caatatattt ctaaaacatc agaagatgtt
     8161 ggaacgaaca attctagtaa ttcaaatagt actaataatt ctgataaaaa accatctagc
     8221 gaagaatcaa ttgaaggcaa gaatggtaag gtaacatctg ctgtgagttt aaatgtaaga
     8281 agtggtcctg ggacaagcta ttctataata ggaaaattaa atggtggaga tgttgttgaa
     8341 ttaaaagcta aaagtaatgg ttggtataag gtaaagttat cgagtggaac aattggatgg
     8401 gtgagtgcca gttatatttc tgagactaat gaggatacaa aagaaaaacc aaattcatca
     8461 tctaaccaaa attctcaatc taatagtaac tcaaagccat catttactgg aaattcagat
     8521 aaatctacag caaaaggttc aacaatcgta gattttgcat atactcttat tggaatacca
     8581 tatcaatggg gagcttcagg acctgataaa tttgactgtt ctggatttac acagtatgtt
     8641 tttaaacatt ctgtaggcgt ttctattcct agagtttcta gagaacaggc taattttgga
     8701 agtgcaattt ctatgggaaa ttatgcacca ggagatttag tttattttga cactgatggt
     8761 gatggaacaa ctaatcatgt aggtatatac gtaggaaata gtaaatttat ccattgtagt
     8821 ggtactcaga ctaatcctaa taaggttaaa gtggataatt taactagttc atattggtct
     8881 aaagtattac ttggtgcaag aagatttgtt tagtaagtac aatttcttat taaaaaatta
     8941 gaagaaataa ttatttatat tcataaattg tgactcttaa aaatatactt tattaataat
     9001 ataattttgg gagggacaaa ctaatgaata gaagaaaaac gatatacaga ggatttaata
     9061 ataatagaca taagattgat ttacgtaaat atgttataac gattgcttgc ttgtgtctaa
     9121 ttggctatta ttcttataca aaaataaaag atagcaagat attggagtat gtatcggcta
     9181 aaataccatt tctaaataat tcatcagata taacttataa agatatatct gatgaattaa
     9241 attcaataaa aaaagggaaa aaatctaaat cacaaaccaa ttcagatgat aaacaagaaa
     9301 ctaatccaga aaaagcggta aataacacta aagagccaga agaagtcaaa ttagctacta
     9361 tagaaggctg ggatatgtat actattcaag ttgctgcaat agataataat gatgatttga
     9421 aaaaaataca gacatcatta gttaataatg acataccttt ttcagttatg gagaaggatg
     9481 gagtaaaaaa aatacagacc tattcctctt ttgatgaaaa tgatgttaga aagcagataa
     9541 gcagtgtaag aaaggtgttt ccagatgcat ttttatcaca cttagatgca cctatgttgt
     9601 ctttagagta tacaagtaac tacgcttata tagagagtat atctaaagaa ttaaataaat
     9661 taataacaaa ctttaaagaa gaatcaagtt tttggtcgaa tgctgaaaat aatgtagata
     9721 tggaaaaata taatactatt ttgacaaata gaaaggcaat atcacaaaat atatcaaaag
     9781 aagctgaaaa gattgattat tctgaaatgc gtttatttaa agataattta atagagtatg
     9841 taaagaatgt gaatgaaaaa attgatacag cttcaaaagc agcaaatgaa gaaaaatata
     9901 gtgtaagtaa aagtctgctt ttatcatcca tgcaggagta ctctatgttt ataaattcta
     9961 taaaataaaa tacagaaaat ttggacttta gaaagctata tgaaaaggat tgtttaatta
    10021 agcaatcctt ttcctcaatt tgacttaata tagaggtgtt gatttataaa ataaattata
    10081 aaaatacgga tattttttta acaattgtta agatttttta atatatatag tatacttata
    10141 gaaggcagaa aaaatgtttt tttatagata agggggtaaa acaatgaaac tcttaacttt
    10201 taagggaggg atacatcctc catatagaaa agagtactct aacacaaagg cacttgaaaa
    10261 agctcaagct ccaaagatag tttacattcc tcttcagcaa catatagggg caccagctaa
    10321 acctattgtt gaagttggtg atgaagtaaa gtttgggcaa aaaataggtg aacaacaagg
    10381 ttttgtttca tgtaacgttc attcttcagt atcaggtaaa gttattgcta ttgaacaaca
    10441 tgaagtacca ggaggttcag ctcaatgtgt agttatcgaa aatgacttta aggaagaatt
    10501 acatgagagt gttcaaccaa aaggtcagtt agaggatttg agcaaagaag atatagtagg
    10561 tatcataaaa gaggcaggaa tagtaggtat gggtggagct acattcccta accatgtaaa
    10621 agtatctcct ccaccagata gcaaggcaga agtagttata ttaaatggtg cagaatgtga
    10681 accatactta actgcagacc acagattaat ggttgaaaat ccagaagatg ttgtgtttgg
    10741 tttaagagca ttaatgaagg tattagatgt caaaaaagga tttataggaa ttgaaacgaa
    10801 taaaccagat gctatagaag caattcaaaa tgtagctaaa gactatagcg aaatcgaagt
    10861 tgttggcctt caagtgaaat atccacaagg agcagagaaa caacttattt atgcgtgtac
    10921 aggcaaagaa gttccatctg gtggattacc aatagcagca ggtgcagttg ttgacaatgt
    10981 tgccacagca gcacagatag ctaagtctat taaaacaggt atgcctttgg ttgaaagaat
    11041 cactacaata acaggtagtt gcatcaaaga gccaaagaac ctaataacaa aagttggaac
    11101 attagtttca gaaataatag aacaatgtgg tggatttaaa gaagataaga agattggtaa
    11161 ggttataatg ggtggaccta tgatgggaat agctcaatat actactgaaa tagcgactaa
    11221 caaaggttct tcaggaattt tatgtttgga tgaggaagaa tcacgtactc cagatattca
    11281 aaactgttta agatgtggaa gatgtacaga tgtatgtcca tcattcttac aaccactttt
    11341 cataagtgca tattctttaa aagatgacta tgacacagct gaatatcata gagcaatgga
    11401 ttgtatagaa tgtgggtctt gctcatttat ttgtccagca agaagaccat tacttcaatc
    11461 tataagatca gcaaagagag aaataggagc aaagagaaga aagcaagctg ctcagaaata
    11521 aagaaagtta agggggaaaa acgatggaaa ataagttgat agtatcatct tctcctcatg
    11581 tgagaagtaa tgaagatact tcatatataa tgaaacaagt tattatagca ctccttccag
    11641 cagcagtagc aggagtatac ttctttagac ttaatgcttt gagtgctatg tttttttgta
    11701 tacttggtac agtaggtact gaatttttat atcaaaaatt tacgaagcaa aaaagtacta
    11761 taggagattt ttcagctgtt gtaacaggat tattattagc atttaacgta ccagcatcac
    11821 ttccttggtg gatgtgtcta gtaggaggaa tatttgcaat attagtagtt aaaatggtat
    11881 ttggtggaat tggatgtaac tttgtcaatc cagcacttgc tgcaagagca tttttattag
    11941 catcattccc agtagcaatg actgcttgga ctcaaccagg tgttaactgg ataggtaaaa
    12001 atttagatgc agttactaca gcaactccat taagcttttt gaaaaatgga gcagcaggac
    12061 tggcagacct ttctagcaat ggaattagtc ttgctgacat gatgataggg aatattggtg
    12121 gatgtatagg tgagacatca gcaatattat tattattagg tggagtatac ctaatgtata
    12181 aaggcataat aaattatgtt ataccagtat tttacatagc aactgtattt atattaacat
    12241 tccttttagg tggatttaat ataactttcg caatatatca actgtttgct ggaggactta
    12301 tgttaggtgg attcttcatg cttacggatt atacaacttc gcctatgact aaaaaaggtc
    12361 aaataatata cgctgtatta gctggtctta taacaactgt tataagaatg tatggtggat
    12421 atccagaagg tgtatcttac tcaatactat tagtgaactg tcttgctcca cttatagata
    12481 agtttgttag aaatagagta tttggggagg tggctaaata atgaacagta tggtgagatt
    12541 aggtggtact ttacttgcta taagtgcaat agctgcatta gctcttggag ctactaatca
    12601 ggttacagct ccagtaatag aacaaagaaa tatacaagca aataatgaac ttagaaaagc
    12661 agtccttcca gaagcaaaag aatttaaaga aatgaaggaa gatacttaca aaggccttgg
    12721 agatggtctt atagctgaag tgtatgaagg tttagatggt tctgaagtgg ttggatatac
    12781 tttaaaagct aaaccaagtg gatatggtgg agaaattgaa gttatggtag gtatatcatc
    12841 tgaaggtcaa gttacaggtg ttgacattgg taatatgtca gaaacagcag gtcttggagc
    12901 aaaagctaag gatgatgcat ttaagggtca atacaaagga aaaactgctg agcctcttga
    12961 agtagcaaaa ggaagtacaa cagcagataa tcaaatatta gcaatatcag gtgcaactat
    13021 tacatctaca gcagttacta caggagtaaa tgctgctata gatgttttca atagtgctct
    13081 taataaataa ggagggttaa ttatgaattt agctaaagta tttaaaaatg ggctaataga
    13141 tgagaaccca acatttgttc aagttatagg tatgtgtcca acactagccg ttacaacttc
    13201 agcaataaat ggaattggta tgggtctttc aacagcagca gttttaatat gtgcaaattt
    13261 agttatatct ttaataagaa aaattacacc agataagata agaataccta tatttatagt
    13321 agttatagct acatttgtta caatagtagg tatgctttta aaagcatatg ttcctgctct
    13381 tgataaggct cttggtatat atataccatt aatagttgtt aactgtttaa tattagctcg
    13441 tgcagaaagt tttgctttca aaacaggagc tatgccttca atagttgatg gtgtaggtca
    13501 aggtcttgga tttactgttg cacttacaat aataggtgca gtaagagaat tacttggaaa
    13561 tggtagttta tttggaatga cattatttgg agcatctttc caaccagtat taatatttat
    13621 attaccacca ggtgcattct taacattagg attcttattt gcaggattta ataaattaag
    13681 aagtaaaaaa gcatagtgga ggtgtaataa atgaatttaa tacttttatt tttaagtatc
    13741 gttcttgtta ataacgttat aacatctcaa ttcttgggta tatgtccttt cttgggagtt
    13801 tctaagaagg ttgatacagc agtagggatg ggagttgcag ttacgttcgt tttaactcta
    13861 gcttcaatta taacttattt tatacagatt ttattagtaa aaactggaac tggattctta
    13921 caaacaatag cttttatatt ggttatagct tctatagttc agttcgttga aatggtaatt
    13981 caaaagatga gtccatcttt atatcaagca ttaggagttt atttacctct tataactaca
    14041 aactgtgcag ttcttggtat agctctagtt aatgttcaaa aaagttataa tttagtagaa
    14101 acaataataa acggatttgg agccggagct ggatttactt tagcaatagt aatattcgca
    14161 ggtataagag aaagactaga attagctgat ataccagaag catttaaagg tttccctata
    14221 acgcttatat cagcaggttt aatgtcaata gctttcttag gatttacagg acttataaag
    14281 ctataaaaaa gaggggtgaa aatggtgata cttacagctg tattagtttt aggaattatg
    14341 ggcttaatct tcgggatagt actagatttt gcatctaaaa agtttgctgt agaagtagac
    14401 gagagagtgg aagctatact aggagtactt ccaggagcca actgtggagg ttgtggattt
    14461 ccaggttgtg gaggtcttgc aaatgcgata gttgaaggca atgcaccagt taatggttgc
    14521 cctgtaggtg gagcagatgt tggtgcaaaa gttggagaaa taatgggaat aagtgctgaa
    14581 gcaggtgaga aacaagtagc aaaagttatt tgtaaaggaa cttgttcaag tgcaaaagat
    14641 aaatatgagt atgaaggaat atcagattgt agagcagcaa atgttttaaa ctcaggtgct
    14701 aagatgtgta aatttggatg tttaggtctt ggaacatgta aagatgcttg taaatttgat
    14761 gctatttcta tagttgatgg aatagcagta atagatgaag aaaagtgtgt aaattgtgga
    14821 aaatgtaaag aagtttgtcc taagggtata ataatcacaa aaccagaaag tcaagaagta
    14881 gttgtagagt gtaatagcaa agagtttggt aaagctgtta aagaaaaatg tactgctgga
    14941 tgtattggct gtggaatgtg tgtaaaagct tgtaaatttg atgcaataat atttgaagac
    15001 aaaatagcta agatagaccc taataagtgt gtaggttgta tgcaatgtgt agcaaaatgc
    15061 cctacaaaag taatatcagg tgacataact aagaaaaaga aagttactat tgaccaagaa
    15121 ctttgtgttg gatgtacagt gtgcaaaaaa caatgtaagt ttgatgcaat agagggagaa
    15181 ttaaaagaaa aacataaggt agatgcagat aaatgtgtag gatgccattt atgtatggaa
    15241 aaatgtccaa agaaagctat taaaattttg taatatggac aaaataagga tatggaataa
    15301 tttccatatc tctaatgagt acataaaaca gaggtatgga ataatttcca tacctctatt
    15361 ttatgtatat ttattctaat ggtaataaat ataacaatag tgtaacaaaa aaggttcgac
    15421 atttctgttg aattttttac aatatagtga tagactaaat aggtacaaat tacgtacaaa
    15481 tgaggtgaat aaatgaatat aatcttggca tcagcctctc caagaaggaa agaaattcta
    15541 gagaatacga atgtaagatt tgatataatt aaaaatgaaa ttgatgagat tatattggaa
    15601 ggtgaaacac caaaacattt agttatgaga ttagcttttg aaaaaagtat gtctgtagca
    15661 tctgaacata atgaagatgt tgttattgga gctgatacag ttgttgtttt agacaatgct
    15721 attttaggaa aaccaaaaga tgagtcttgt gcaagagata tgttaaaaag actatctgga
    15781 agagagcatc aagtcataac aggtattagc ttaataaact tgtgcgaaga taaaaaggta
    15841 attgactatg taatcagcaa tgtgaaattt aaaacgttat cagagcagga tattgaggat
    15901 tatctgaaaa ctaatgagtc atttgacaaa gcaggagcct atggtataca aggttatgga
    15961 gctttgttag ttgaagaaat tagaggagat tattttaata tagttggtct tccaatttca
    16021 aggttaggcg acctattaaa aaaatatttt agtataaatc ttttttatgg agtgtgattt
    16081 atctgaaaaa gtcatttaat tcaaccatta aggtaaaaga aatggcacca gaggaaagac
    16141 ccagagaaaa gatgcttgcc aaaggcgtaa aaagcttatc aaatgctgag ttgttggcta
    16201 tacttttaag aactggcaac aagaataaaa atgctattga attagccaac tatataataa
    16261 atagagatat tcagggtatt agacatttag aagatatgac aatagaggag ctgtgtaata
    16321 tagatggaat tgggttatca aaatcaaccc aaattaaagc agctttagaa ctaggctcta
    16381 gagtagctag ttttaaacct ataaagtata aaataaggaa tccttgggat atacagaggt
    16441 attatatgga tagcctaagg tatttaaaaa aagaggtttt taaagcggtt cttttaaaca
    16501 caaaaaatga gataatatct gatgtagatg tatctatagg gactttaagc tcgtcattag
    16561 tccatccaag agaggttttt aaagaagcta taagaagaag tgcaagtaag ataatagtga
    16621 tgcataatca cccttcagga agtgtagaac catcaagaga agataaaaat atcacatcaa
    16681 gacttattaa atgtggagaa ataattggaa tagaaataat agaccatata attattggag
    16741 atggattata ctttagcttt aaagaaaata tgataatttg actttatatg tgataaaata
    16801 atagaagaat gttttaaaca tgattcttaa tagtaggaag gagtaaaatc atggctaagg
    16861 aaaaaaagaa agaaaaaaaa ggttttttta gttttaataa gatgacaaag gatatgggaa
    16921 tagatttagg gactgcaaat acattagttt acataaaagg acaaggtatt gttgttagag
    16981 aaccatcagt tgtcgcaata agagatgata gtaaagaggt attagcagta ggtgaagaag
    17041 ccaaaaaaat gataggtaga acaccaggaa atatagtagc tataagacct atgaaagatg
    17101 gagtaatagc tgattttgac ataactcaat caatgattag ctattttata caaaaagcgg
    17161 ctgataaaaa aggtgttgta agtccaagaa tagctatatg tgttcctttt ggagttacag
    17221 aagtagaaaa gagagctata gaagaggctg caagacaagc aggagctaaa gatgcattcc
    17281 ttatagaaga gccaatggca gcggctatag gggctggatt aaaagttgaa gaaccagaag
    17341 gtaatatggt agttgatatt ggtggaggta cttcagaaat agctgtaata tctttaggag
    17401 gaatcgttac tgctaaatct ataagaatag gtggagacga atttgacgag tctatagtgg
    17461 cttatgtaaa aaaagaatat aatcttatga taggtgaaag aactgctgaa aatgtaaaaa
    17521 ttaacatagg ttctacattt aaagatgatg aagaaataaa tatgcaaata agaggtagag
    17581 atttaatctc aggattacct aaaacaatag aaatatgctc tacagaagtt agagaagcat
    17641 taaaagaacc tgtaagttca atagtagatg caataaaatc tacactagaa agaactccac
    17701 cagaattagc ctcagatata atggaaaacg gaataatgct aacaggagga ggcgctttgc
    17761 ttagaggtct tgataagctt attacacagg aaactggtat gtctgtacaa atagcagaaa
    17821 cacctcttga ttgtgttgca cttggaacag gtaaatctgt tgaagaccaa gaaatctttg
    17881 aaaaagtatt aatgatgaat actaagaatt agaagttggt gatggccttg agatttgaca
    17941 agaacaaaaa tgagaaaaaa aggattaatg ttaaagtgat agcaacgggc gtagttgcta
    18001 tcactttaat tggaattgtg ggtatatcaa ttggtaaatt ttctagtggt agtccagtaa
    18061 atttaggagt agcttcagat gctattacaa gtgtaggtaa gggaataaat gatggatttt
    18121 cttttatcaa aaatggtttt aaagatgtag caaattttaa agataattct aaaaaggtaa
    18181 aaaaattaga agaagaaaat gaaaaactta aaaaaaatat gatagcttta aatgccaaac
    18241 tagataaaac agaatcgcta gaagagttaa aaaagacact gaactttgta caagaagagt
    18301 ataaggcgac aagtatttca gcaagtgttg ttggtaaaaa tgatggaaac tggtatgaga
    18361 gttttgtcat aggtgcagga aaaaattcag gtgtaaaaaa agaaagtata gttatgaatg
    18421 gtagtggatt agttggcata gtttatgaag tttccaacaa ttatagtaag gcaatttcac
    18481 tattggattc taaggcatct gtaagcttta aactagcaaa ggatgccaat gctaaaggta
    18541 caattactca aaatactact ttagataata aagatagtta taatagtaaa ggatatttgc
    18601 aaggatatat gtttgactca tcatataatg taattcaagg agatataata acaacatcag
    18661 gtcttggatt cttcccagat ggtataccaa ttggcgaagt tgaaaaagtg gttgatgata
    18721 aagataagtc attaaaatat gtagttgtaa aaccttatgt tgattttaag aatataaatg
    18781 acgttgtagt catagaacca agaaatatag gataaagggg ataaaaacaa tgaaaaaagt
    18841 tttactttgt ctgttgggga ttgtgcttat gactatagaa aatagtataa caaattatat
    18901 agatattttt ggcataagct ttaatttagt tcttatatat gtaaccataa tctctcttta
    18961 tttagatgaa ttagaaggtg ggattatagc agcaataata gggcttatta aagacataac
    19021 cgttggtgga atttttggtg taaatgcatt aattttgttt attattgcat atgcaattgg
    19081 atacatgaga gatcagctat ataaaggtag ttatattatt actttcgttt taatttttat
    19141 aggcagttta attgattcaa ttgtcaatat aggtacatct agtataattt atcaaagcta
    19201 caacatatca acactttttg taaaaggtct actagtagca ccaatagtga atagtttaat
    19261 tggtttagta atatatcgct tatctaaaag agcagtttta aaacttaaag aagattagtt
    19321 ggtgatttca tggaagaaaa taaacaagtt gatagactaa aaataattaa gatagtcatg
    19381 ggcgtgatat ttttagctat tttagtaaaa ataatctata tgactacatt taaatatgaa
    19441 tattacaatg agttagctga gaataaaaca tataaaaagt tggcaataga agctccaaga
    19501 ggagaaataa aagatagata tggaagactg ttggcaggaa ataaaaactt atttactgtt
    19561 caagtttcag gtaacgatat taataagaaa gatgcaaata agcattcaag agcaaatgaa
    19621 atatcattaa aacttataaa tttgctggag agaaatggtg aagaatatgt agatgagttt
    19681 cctatatatg tagaaaatgg aaagtactat tatacatatg acagagatat tagggaatat
    19741 aaatcagaaa atggtattcc aaatgattat aatgctaagg aaagttttta ttacttggtg
    19801 gacaaactta tatcagctgg aatattatct caagaagata aaagattgga tgcgacaaga
    19861 ttacaggcaa aactaaatga aaatggatat tatccaccta ttttagttag taaatggatg
    19921 ttcacagcag aaagagataa gagagattgg ttggctagtt ataagataaa agaaactaaa
    19981 ctgagtgcca aagaagcgtt tgaaaaagta agaaatagtg atgcattaga aattgataaa
    20041 agtttgagtg atgaagatgc aagaaaaata atggtcgtaa gggatttgat aaaatcaaaa
    20101 ggatattctc aatataatcc agtaactatt gctaaggatg taggagaaac tacgattgct
    20161 caaattgaag aaagtgctat ggaccttgtt ggtgtttcaa tagcagtaga accagtaaga
    20221 tattatccta atgggtcatt agcttctcat atgttaggat atgtaggaaa aatgccatcc
    20281 actcaaatag aatcatacct tcaaaaaggt tatgaaactg gagatatggt aggtcttgca
    20341 ggagtagaaa agagtaatga aagtagatta agaggaactg atggttataa aatggttaaa
    20401 gttgatgcat tgggtagaat cagtaaagaa attgaatcta aaaaacctaa atcaggagat
    20461 actgtgtatc ttacactaga taaagattta caagaagttt cagacaatgc attaaaacag
    20521 ataatcgaag ttgcttctaa aggaggtact tttaaaagta aatttgggga caaaccaatt
    20581 agtgcatatg caggaaaagc acagtcagca gctcttatag ctattgatgt taaaaatgga
    20641 gaagtattag cttcatcaag ttatcctaat tatgacccaa ataaatttgc aaaaggtatt
    20701 tctacagagg attataaagc acttcaacca aaaaatccaa atgacttact agcaggaagt
    20761 ccacttttaa acttggttac acaaggggaa tttcagccag gttcttcatt taagatggta
    20821 acttcaatgg cagcgttaga aaatggtctg gatccaaact ttactataaa tgaccctggg
    20881 gttataatgt taggtaaaaa atcttttggt gactatgtat ggaaccatgg tagaggaaac
    20941 catggtatga caaacttata taaagcaata caagagtctt gtaatatata tatggcaaca
    21001 attggtacag gtaaaacatg gccagatgga aaaagcattg gtatagatat gaatgcaaat
    21061 aaaatacttg agtatgcaaa attatttggg cttgaccaaa atacagggct tcaagatgaa
    21121 gtagaagaaa gagcaggtaa agttcctagc acagaagata aattgaaatc aacacaagct
    21181 cttctaaagt caaatttaga aagagaaatg gcaaatgatt ttgttgatat aactagagaa
    21241 aaaaatccta aagaatatga gaaaagaatc aatgagattg taagctgggc agcagaaaag
    21301 aaaactcctg gtagagttga aacaatgaat aggctaaaaa aattggatgt taaagaagat
    21361 agaattgaag aagtagcaga tttagcagta tttagttatt ttaactttgc aaaatggagt
    21421 actgcagata catttaactt agctataggt caaggtgaaa atgcttatac accagctcaa
    21481 atatcaagat atgtagctgc tatagcaaat ggaggtaatt tagtagaatt atctgtagtt
    21541 gatagagctg tttcaagtga ttattcatca gttaaaatta atgaccagaa gaaagtcgaa
    21601 aaaatacctt ttaaaaatcc agataactta aaagaattaa caaaaggtat gaaattggtt
    21661 gcaagacaag gtacagcgaa gagtgctttt gctgattttc caatagatgt agcagcaaaa
    21721 actggtacag ctgagaaaag tgggaaaata cctacagata acgagtatga atatttaaaa
    21781 agtcatatgt catcttataa tgtcaaccta aatgatgcga ttaaactagc tgataagatg
    21841 aaagcagaaa aagaaaaaga gctttcatta gctaaggaaa aggaaataaa aaagaaatta
    21901 gaaaataaag atttgaaaga cgaagaaaga aagaaattag aggaagaatt agaagatgga
    21961 gtaaaagtta gattagagga cactgataag gtgaattctt catatctaag aaaagctata
    22021 aaagaattaa atccaaaaat aacagatgac caaatagata gatttaaaca agattatggt
    22081 tcttttacgt ggactgttgc ttttgctcca gcagatgacc cagaaatagc tgttgtatgt
    22141 gtaattcctc aaggtgattc aagtgtattc tcacttttac caactagaga agttattgga
    22201 acttatatgg gattagagcc aactaatagt aaaaatgaca acaagacgaa tgatgttaac
    22261 aattcttctg acgaaaatat aaatttcgag tcacaaatta atagatagct caatctatgt
    22321 ataaacttta gctttatata gaaaaaataa aagggtttaa agcgtatttg aagaatataa
    22381 atgatatatc actctggagg ttgttatgtc tttaagagaa atttgtagtc aagaactagt
    22441 agagttcaag ggtaataaaa gagggataat agtaaatata aaaagagaag ctccatttga
    22501 ggaaatacag gaaaaaataa taaacaaatt ggaagcatat gttggctttt ttaatggggc
    22561 taaaattagt aaaattaata gtgattgttt aactgacatg gagattctag aacttaaaga
    22621 aggaattact tctagatttg atgtggaatt tgttgaagat caaaaaattg aagaaaatag
    22681 taattttcca acaaaatatg tcaataccct aagatctggt gaaaatattg aatttgaagg
    22741 tgatgtagtt atattgaatg atatgaaacc tggttcaaaa gtcctttcaa aatcaaatac
    22801 agttgttatg ggagatataa atgctggtgc taaggttgta gcaggaggta atgtttttgt
    22861 aatgggtaaa atagaaggtt ttgtacatgc aggtgcagaa ggcaatgaat ttgcatatgt
    22921 tgttgctgga aatcttaatc ctaaaatatt acaaatagca gataatattg cagaagctcc
    22981 agatgatgaa gaaaattatg aaagtgaatc agaaattagc ccagaaatag cctttgtaag
    23041 taatggaaga attgtaatcg aaagctattt gtcaaagtta gacaaataga aagaaaaata
    23101 gggggtagta ttatgagcga agttatagtt ataacatctg gtaaaggtgg ggttggaaaa
    23161 actactaccg cagcaaactt aggaactgcg ctaagcctag aaaataaaaa aacagtagtt
    23221 gtggatgcag atattggact tagaaactta gatgtagtaa tgggtcttga aaatcgaata
    23281 gtttatgaca tagtagatgt agttgaagga acttgtaggc ttaagcaagc tctaataaaa
    23341 gacaaaagat ttgataatct atatttatta ccagcagcac aaactagaga taaaaatgct
    23401 gtctcagttg agcagatgat tgacctgtgt gagaaactaa aagaatcttt cgagtatata
    23461 ataatagatt gtccagcagg tattgagcaa ggctttaaaa atgcagtagc tggggcagat
    23521 agagctattg tagttactaa tccagaaata tcagcagtaa gagatgctga tagaataata
    23581 ggtctattag aagcaaatga aataaaagag ataagattag ttataaatag aattagaaat
    23641 gatatggtta agcgtggaga catgatggat aaacaagata taatagaaat attagcaata
    23701 gatttgttag gtcttgttcc tgatgatgaa agcataatta tatcaacaaa taaaggagag
    23761 ccagctatac ttgattctaa gtcacttgct ggtcaagcat acaaaaatat cgcaaaaagg
    23821 atactaaatg aagaagttcc tctacttgat cttgaagttg aagatggatt ctttggtaga
    23881 cttaaaaaaa tgtttagcat ggctaagtag caaaggagga tacatctgtg ttagatttat
    23941 ttagagtttt ttctaacgag gctaaaacta gtaaatctgt tgctaaagag aggttaaagc
    24001 tagttttagt tcatgataga gtagattgtt caccacaact tttagagatg ataaaaacag
    24061 acattttgaa agtaatagct aattatgcag aaatagaaga tgatggtctt gaaataaaaa
    24121 tgtctaaatg cagaggtgag catgatgaca aacctgtatc tgcattagtt gctaatatac
    24181 cactaaagaa tataaaagat agatgtatgt aattagtgct taaaaggggg atatccttat
    24241 tggtatatgc cccttttatt taattatatg tttaaagata gaaagacggt gattctttga
    24301 aaaaaatcaa tattaattat aagtcgacaa ttaagttgat aaaacagtta gactggaaac
    24361 ttatagttac agtattagct atctttattt ttgggcttgt tatacttagt agtgcaacac
    24421 atgctaattc aacaggttca tataatcaat tgattaaaca aggattagct tttgtacttg
    24481 gtataggaat gattatagtc atattatttt ttgactataa ccttctaggc aggtattata
    24541 aagcgcttta tataataagt cttattttgt tagccatagt tttattacct ggaattggga
    24601 cagtaaaagg tggagctagg tcgtggatta acttaggacc acttgacttg cagacatctg
    24661 aaatagtcaa attaacattt gtactaagtt atgcaaagat acttgaatcc aaaaaggata
    24721 aattaaatac gttaaaggaa gttatgcctg ttgtagttta ttctcttcca tttatcggat
    24781 tattgattgc acaaccagac ttgggaacag gaattgtatt ttgttgtatg atatttgcaa
    24841 tgctgttcac agcaggtctt agttcaaagt tgataaaaag aggaataatc atactattag
    24901 tgtcaatgcc actgatgtat ttaatgatgg cagaccatca aaaggtaaga atagaagctt
    24961 ttctaaatcc agaagatgta actctaaaag gaaactatca agttatgcaa tctctgattg
    25021 caattggttc tggaggcgta actggtaaag gactttacaa tggaagtcaa aatcaagaag
    25081 attttttacc tgtacaagat agtgatttta tatttgctgt tgtaggtgaa gaacttggtg
    25141 taataggaat ggcagtgttg ataatcttat ttatgatatt cctattaagg cttttagcaa
    25201 ttgcaagaga tgcaaaagat ttttatggaa ccctcatagt ggttggtgtt atgggaatgt
    25261 ttggttacca gataatccaa aatataggta tgacggttgc gttaatacca gtaactggag
    25321 taacattacc ttttgtaagt tatggaggaa gttcgttatt gacatcttta gcaaacttag
    25381 gattagtact aaatgtgtgt atgagaagaa agaaaataaa tttctaaatt taaatacatc
    25441 taaacataaa ttgaggagat tagatatatg aatatagcat tagtagcaca tgaccaaatg
    25501 aaaaacacta tggtcggatt ttgtataggt tatgaatcaa ttttaaaaaa gtatggacta
    25561 tatgcaactg gaactacagg aaaaagaata atggatgaaa ctgaattaaa tataaataga
    25621 ttagcatctg gtcctttagg tggagaccag caaataggtt ctttaatagt aacacaagaa
    25681 atagatttag ttattttttt aagagaccca ttgacatctc aggctcatga aacagatata
    25741 caagcgttaa taagactttg tgatgtttat catgttccaa tagctacaaa tctagcttca
    25801 gcagaaatat ttataaaagc tcttgataga ggagaactat catggagaga agttagaaaa
    25861 agcaaaagtc aacgtattta aaaaatatta atattacagt ctaaagaaac agatatataa
    25921 gtgtttaatg ccctagtttt tctgttggaa taaatctagt acctgtagaa atcttatgaa
    25981 agatttaaat gatgaagagc taaatttgag attaaataat taggaaatag attatagata
    26041 gagtagtaga atttaaacta ttactctatt ttaataatat gaaatagaat caagtctatt
    26101 attatatata tttaaactta taggtaatac tatttcaacc aagtaaatgt tgttatgaca
    26161 acattaataa aacaaaaatt tatttttaaa atttgataaa tagctgtata ttagtattta
    26221 tagattaaat attaatatac agctatttat tatttttaag tctattgtag aatataaacc
    26281 ttgtattata gagtactatg taatattata gtaaatataa gtactataca ttatagagta
    26341 gtaggtgaaa aggcggtggt acataatgca gttaaataaa gaagtgttaa aaggttatat
    26401 cgatatatta attgtttcta tattagaaaa gaaagattgt tatggatatg aaattgcaaa
    26461 gcaagtaaga gaaagaagtg agtttgaatt aaaagaagga acaatgtatc ttgcacttaa
    26521 aagaatggaa tctaaaaatt taattaaatc ttattatagc aatgaacaaa gttcaggtgg
    26581 aagaagaaaa tattataatt taactaatga aggtaaagat tttttagaaa taaagaaaca
    26641 agaatggaga tttattaaaa aggttatgaa tcaatttttg ggagaggtgg attaatttat
    26701 gaaactaata gatgaatatt tagataaact atataaaaaa tgtgacaata aaagtactat
    26761 agaattaaaa caggaaatga gatgccatct tatagaatct gcaaatgaat ttaaattaga
    26821 aggattagat gaagaagaag catgtaaaaa agcaattgaa agatttgatg atggtgatga
    26881 aatgcagtat gaattatgta atataataaa agaactatct ttatcattgg ataggcataa
    26941 atcaattgta atggggttta aaaaagtatt aggttacata agtataattg catttttaat
    27001 ttctggattt atgtggtatt acaataatag tttacaacat aatatgtata atttaggaaa
    27061 agaacttgat ggagaaataa agcaattggc agaaagacat gatatgacaa agattggtga
    27121 atataagtta gaacttgaaa aaatacttga taaagataag tatagtaaag tcaaagctct
    27181 tagactatat gtaatagata tgaaagatgg aaacactaat ttaagttctt ctggattgaa
    27241 tgctaatatg gtatatgaga gggaagcaga ttataataac ataagtaatt ttatacagca
    27301 tttaggatat aatggaaaag attttttaga caagaatggg aatatagtaa atccagatat
    27361 tttcttagaa tatttctttt attttgaatc ggagatgtta attccagtag cattcgtatt
    27421 tggattatta tgtataatag cgtattttat attaagattt aaaatttctt taataaaaaa
    27481 taataattaa ataattcacc aaataatttt aatttgtaga gtaaataaga tgtttcaaaa
    27541 taaaatttga atcatcttat tttttattgt ttgttatatt cttttctttt atatttctcc
    27601 atagtggatt gtatctatac ataatcacat taaaaacaac acaacatatg ttaactggaa
    27661 cgcagcagag ggagccaata ctgcttatac attggttact aaaaaaggtg cttgttctgg
    27721 aatgtgtagg agcttgaaag ctttatgtga tgctatggga attgaatgtt attatgtaca
    27781 tagtacaaca aatgaccatc agtggaatct tattcgtttt gaggatggac gtttgtatca
    27841 tgtagatatt gatgccaaca aatcagcagg agcagacatc atatacaaga gtcttactca
    27901 cccattacca tttgacaaga aagcatatcc agctgttggc gaagtagtaa agacacagaa
    27961 tccaacgcca actgttaaga aacctacgcc agctaagcct tctgcgccag ttggacctgg
    28021 gaatcacact atgatagcag atcaacaagg ggcaatactt gatgaagttt atggaaataa
    28081 tctacgtcca aaaattgaaa tgtatgaggg agttccgtgt agtttaatca actcatcaat
    28141 aaatacaatt aagtttacaa gcaaaaattc aaatttagac ccatcaaagc atacagttac
    28201 tgtaataggg tttatgaata caccatatgg tatggttgca ttagcaccag agagcaaacc
    28261 tgttagttat ccttttgagt atgataaggc attttcttta gattttactg gtaagaacct
    28321 ttctgcagca gaattatcaa aaaagtgtaa aaaaataata taattattaa agtagaaatt
    28381 ggtgaaacaa catctaattc tggaataggg ctagtagcat atactagata cgtgaattaa
    28441 tacaagtata ctagtataca aatagaacag actataaata atgcaccctg tgcgaaaggg
    28501 tacatttatt attatattag tcattttgga aaataaaaaa ggagttgaac ttaaaattag
    28561 attagaaaaa ttaattttga gacaactcca ttttaattta tttttaaata taaaatcatt
    28621 tattttaaat aatattatgt ttgattaatg gctatttaac taattttgca aattctgcac
    28681 caaatgccat acactctttt aatgtctctt cactagggaa gaattttttc ttaagagatt
    28741 ctacaggcat tttgaatgac atagatttaa gtaaagtctc agccatagtt ataccttcac
    28801 cactccaacc aaatgaacca aatactcctg ctatcttgcc ttggttagcc attgggtcta
    28861 taacagagaa taaatcccac ataggtttaa ccatagtttt gtttatagtt ggagagccta
    28921 gtaatattac ttttgacact actaatgtat cgtgcatttc tgttaatgtc atatcttcta
    28981 aatcatataa ttcagccttt gcaccttctt tatcaagtcc ttcttttatc tttttagcca
    29041 tctctaaagt attactataa gctgataagt agaatataga aacttgattt tgattagttg
    29101 tattaacagc ttctgtagac cactcaacat atcttttaac agcagccatt gggtctttag
    29161 taagcattgg accatgagaa gtcaatatag tatcaaattc tatgtttagt cctaccacct
    29221 tatctacagc acttaaaaca tgtttagcaa atggcttaac tatacaatca tagtagtgtt
    29281 tagctgattt tagataatct tcactattca ctacctctgc atcaacactt gcaaagtgac
    29341 aaccaaatgc atcacaagtt aaaagagtct tgtcctcctc aatgtaagta aacattgtat
    29401 caacccaatg taagaatgga gcagttataa atctaagatt tcttttaccg atatttaaaa
    29461 tttcaccatc ttttattaca tgacagttaa aaggtctatt tatttgacca tctaagtata
    29521 gtttagcagc tttagtacaa taaacttcta tattaggatt tatatctaat aagtatttta
    29581 aactacctgc atggtctggt tctgtgtgat gaattacaac atagtcaatt ttagctatat
    29641 cagtaacctc tgataaatta cttaaaaact catctttaaa atttgccttt acagtgtcaa
    29701 ataaaaccgt tttttcgtcc ttgattaaat aagagttgta agttgtccca aactcagttt
    29761 ccattattat gtcgaatact tttaaacctt catctactac tccagtaaag tagatatctt
    29821 tttttacttc aaaaacttta ctcattttta accctcctaa aatttatcat tatataagta
    29881 acatacccca ttttgaggtg aatgaaacaa aagatgtcat gataagtcat gtaaaacaat
    29941 agttttatgt ttataatata tcatactttg taaaaaaatt gtatttcaat aaaaatttaa
    30001 tagaaaatat tcttaaatat ttttagctat tctattttgt gaataatatg tattttaaat
    30061 tcaatatttt agttatattt ttgatagaaa atattttatc gtgtataata ttacttataa
    30121 ataagaataa aaataaagag cttgtttgga ggaattttaa taaatgaata aagtagactt
    30181 gaaaaaaatc ttaaaaaaag tagaaaagcc tgctagatat cttggaaatg aaataaattc
    30241 aattcataaa gatactagta atagtgaatt gataagatat gcacattgct ttccagattt
    30301 atatgaagtt ggtatgagtc acttagggag tcatatatta tatgatgtaa taaataagga
    30361 tgaagatgta ttttgtgaga gagtgtattc tcctgcagtt gatatggaaa atataatgag
    30421 agaaaaaagt ataccattat ttgcattaga gtcaagagag cctataacaa actttgattt
    30481 tgtcactttt acacttcaat atgaactttc atacactaat atcttaaata tattagattt
    30541 agccaatata ccaatattaa aagaagaaag aactttggaa gacccattta taatggttgg
    30601 tggtccttgt gcttataatt ccgaaccatt agcagatttt gtagatgtag taatattagg
    30661 tgaaggtgaa gaggttaatt tagaagtagt aaatgagtat aaagaatgga agaaaaataa
    30721 aacgactaga gaagattttt tatataaaat atctagcata gaaggagtat acataccaag
    30781 tttttatgat gtcaagtaca atgaagatgg tacagttcaa agtgtaactc ctaatagaga
    30841 agggattact aaaaatccta ctaaaaggat aataaaagat gttgagactg tagattatcc
    30901 agaaaaacta atagtacctt atatagatac tgttcatgat agaatagtac tagaattatt
    30961 tagaggatgt actagaggat gtagattctg tcaagcaggt atgatataca ggccaataag
    31021 agaaaagagt gttaaaagac ttaaagaaat attagataaa ttagttaaga atactggata
    31081 tgatgaaata tcattatcat cacttagtac gagtgattat agtaagttat cagagttgac
    31141 tgattatttg gtagatgaat atgcatctaa taatattggg atttcgcttc catcccttag
    31201 attagataat ttttcaatgg aaattgctga taaaatacaa caagtaagaa aatctggact
    31261 tacttttgct ccagaagcag gaactcaaag acttagagat gttataaata aaggtgttac
    31321 agaagaagat ttggaaaatg caacagaaag agcttttgag atggggtgga atagtgttaa
    31381 gttgtatttt atgattggtt taccaactga gacttatgaa gatttagatg gtatagctaa
    31441 attggcttat aaagttattg atatttatag aaaagtaaat ggaggaaagc taaagagaag
    31501 ttttagtgtt acagtgagta cttctacatt tgtaccaaag ccatttacac ctttccaatg
    31561 gcatggtcaa gatactacag aagaagttat taataagcag agacatttag taaataaatt
    31621 aagaaataac aatataaaat acaattatca tgattcaaag actagtttga tggaagcagt
    31681 agtagctaga ggcgatagaa gaataggaaa agttatatat gatgcattta gactaggtgc
    31741 taaatttgat ggatgggcag aacattttaa tttagatata tggaaagaag ctatggaaaa
    31801 gaataatctt tctatagatt tttatgcaca tagaaataga aactatgaag aggtatttcc
    31861 ttgggaccat atagatgtag gtattagtaa aaaattctta attagagaag acgaaaatgc
    31921 taaaaaagaa aaaatcactt ctgattgtag acataactgc aatggttgtg gaataaatat
    31981 acatgatata ggaagggggc tttgctaata tgagtaagat aataagagta aaatttaaaa
    32041 aggaaggcga catgatatat atatcacatc ttgaccttca gagattgtta caaagagcgt
    32101 ttagaagagc tgaaataaac ttatcacatt ctcaaggatt taatcctcac cctaaaatga
    32161 gttatggcaa tgctttggct ttaggggcag aaagtcaagg tgagtatgta gatattgaaa
    32221 tagaagaaga tgatttatca gtagaggaat ttttaaataa agtatcaatt caacttccag
    32281 atgggataga ttttatcaaa gcaaaagaaa ttgatagaca aacaccttct ctttcttctg
    32341 tgatagacta tggagaatat ttgtttaata tagatttgaa aagacctatg acgaaagagt
    32401 ttgtaaaaag aaaagtaatt gactttatga ataataaaga aataatcata acaaaaaaga
    32461 ataaaaaagg taagatggtt gaagtagata taagacctat gataagaacc tttgatgttt
    32521 taaatttaga agatgaacat attactctta ctgctactat agctacaggc tcaaaaacta
    32581 atttaaatac taatatactt ataccaaaga tattagagat gtttgaactt gatattgacc
    32641 cattagatgt tgatatattg agaagagatt tatatgtatt agaagatggg gaattagtga
    32701 ctcctatgta agctcgagag gtgaagttgt gaaaaagata gttattgagt ccctaatagg
    32761 gtcccagaaa acagcagtac ttgaagatga aagattaaca gaactttttg ttgaagacaa
    32821 tttaaataag aagactgtat ccaatatata tcgtggaatc gtaaaaaaag ttataccagg
    32881 aatagaagct tgttttgtag atattggatt taagaaactt gcttatttac aattaaaaaa
    32941 gggaagtact ataaaatctg gtcaggatat tttggttcag ataaataaag aagaaatagg
    33001 aactaaaggc gcaaaattaa acactgagat tagtatttct ggaaggtata ttgtctatat
    33061 accttccaat gatagaacta caatatcaaa taaaattact gatgaaaaag aacgatttag
    33121 attaaaaaaa attactaagg cagtaaataa ggaaaatcta ggattaataa taaggactga
    33181 ggctcaaggt tgcactcatg atgaaataaa gaaagatata gaagagttga aattaaagta
    33241 tgaaaacatt ttaaaagaat ataaacttgg tataggtccg aaattattat ataagtcttt
    33301 agattttgca actaaatatg taaaagataa tgtgaatgat gatattgaat ctataattac
    33361 caatagttat gataagtact ctgaacttaa gtctatttta agaggtatag ataagactta
    33421 tgttgataaa ctgtgtcttg aggaaaatag agatgtattt gatttataca gaatagaatc
    33481 taaaatagaa aaattattaa ataaaaaagt atggttaaag agtggaggtt atttaataat
    33541 tgaaaaaaca gaagctctta cggttataga tgtaaatacg ggtaagttta ttggaactgg
    33601 taaacttgat gaaaccgttt ataaaactaa tcttgaagct gcaaaagaaa ttgtaagaca
    33661 gcttagaatt agagacatag ctgggataat aataatcgat tttattgata tgcataaaaa
    33721 gaagcatcaa aaggagattt tacacatcct agaagaagaa tttaataaag ataaaagaaa
    33781 agctgaagta ttaggtatga caaaacttgg tttagtagaa gttgctaggc gtagagaaaa
    33841 agaatccatt gataagtatt atttaatgtc ttgtccatgt tgtgatggtg aacaaacaat
    33901 aaaatctgta cattatatac tagatagtat tgaaaaagaa attatgagaa taagtgaaca
    33961 tactgtttac aaaaacataa tggtagaatt taatgatttt atttttgaac aaataaaaga
    34021 atattatatg gatataattg ataaaattgg tgaaaaatat aatataaaga tttctttaaa
    34081 cgcaaatagt acattaaagc acaataaaac caatgttatt ttcgataaaa tagttgacaa
    34141 taaaatgtaa atattttata attaataatt gtaatgccgc acagtaaagg tttaaatctt
    34201 caaatgaagt accttgtact ggcgagtttg aggccgagga ggtgtattta atgtacgcta
    34261 tagtaaagac tggtggaaag caatataaag tttctgaagg tgatgtatta ttcgttgaaa
    34321 aattagaagc taacgcaggt gatgttgtta ctttaaacga agtattagct tgctctaaag
    34381 atggagaatt aaaattaggt tctccagtag tagaaggagc atctgttcaa gctaaagttg
    34441 ttgaacaagg taaagctaag aaagttatag ttttcaagta taaagcaaaa aaagattaca
    34501 gaagaaaaca aggacatcgt caatcataca ctaagatagt tgtagaaaaa ataaacgctt
    34561 agttattggt taagttatga taaaagttaa atattattat aatgatgatt tcttgttgca
    34621 aggtttttgt ttaaagggac atgctgattt tgctgaaata ggctatgata tagtatgtgc
    34681 tgcagttaca tctaatgcta ttgcagttat aaattcttta gacaaattac agaagattga
    34741 atttgaaaaa gtagtaggag aagaaggtca tatagagtgt atagtcaaag atacacatgt
    34801 aaaagacgca caattattac taaatcactt tcaattagcg gttaaagaaa ttaaacggga
    34861 atacccaaaa aatataaaaa ttttaaaaaa gtagggggtg actccatatg ttaaacatga
    34921 atttacaatt attagcatct aaaaaagggg taggttcttc taaaaatggt agagattcta
    34981 tatctaaaag attaggtgtt aagagattcg atggtcaatt agtaactgct ggaagtataa
    35041 tagttagaca aagaggaact aaaatacatc caggaactaa tgttggaaaa ggtagtgatg
    35101 atactttatt tgcattagtt gatggtactg ttaaattcga aagaaaagac aagaagagaa
    35161 aaaaagttag tatatatcca gtagcaatag ctgagtaata tacataaaag gagtgttgag
    35221 gcactccttt ttcttataat actgatgaat ttataatggt atttttggta atgctaatta
    35281 aaagttttta attaagtagg tgaagaattt gtttatagat aaggcaagaa tatttgttaa
    35341 ggctggaaat ggtggaaatg gttcggtagc atttagaaga gaaaaatacg ttccagctgg
    35401 tggtccagac ggtggagatg gtggtcgtgg agcaagcatc atatttgaag ttgatttggg
    35461 gcttagaact ctaatggact ttaagtacca gaaaaaatat caagctcaaa atggtggcga
    35521 cggaagcaaa ggaaaaagag ctggtaaaaa tggagaaaat ttagtattaa aagtaccagc
    35581 aggtacagta ataagagatg aggctacagg tcttgtatta gcagatttaa aaaaagaagg
    35641 agatacagct atagttgcaa aaggtggtat aggtggtaaa ggtaaccaac actttgcaaa
    35701 tgcagtaaga caagctccag cttttgcaaa atctggtaca gatggagaag aaagatggat
    35761 aactcttgaa cttaaaatga tagcagatgt tggtctttta ggatttccaa atgtaggtaa
    35821 atcaacattt ctatcagttg taactaaagc taaacccaaa attgcaaact atcattttac
    35881 aacacttaca ccaaatctag gtgttgttca aactaagttt ggagatagtt ttgtacttgc
    35941 agatatacct ggaattatag agggtgcttc tgaaggcata ggattaggtc atgagttctt
    36001 aagacatgtt gagagaacaa aggtattgat acatattgta gatatatctg gattagaggg
    36061 aagagaccct attgaagatt ttgacaagat aaatgatgag cttaaattgt acaatgaaaa
    36121 gctttcaaag agaccacaag ttgtagttgc aaataaattt gatatattag aagatgagag
    36181 taagtttgag aagtttaaga gtgaattaga aggcagagga tatacagtat ttaaaatgtc
    36241 agcagcaact cgtcaaggca tagatgaagt aatagcctat gtttctaaaa tgctaaaaga
    36301 agtagaagat gtggagctag tttcagaaga agaaatgtat agaccagaac ttgatattgg
    36361 tactgaagaa gagttaagta tagatattga agatggtgtg tatgtagtta caggtaaagc
    36421 acttagaaga ataatgtatt ctgtaaattt tgatgatatg gaatcccttc aatatttcca
    36481 aaaagctatg gagagtcaag gtgtttttga taggcttaga gaaatgggaa tagaagatgg
    36541 agatgtggtt aaaatttatg aattagaatt tgagttttac aattaattta aatatagatt
    36601 atagataatt taagtataga attatagagg tgagaatatg ttaaaaggaa aacaaagggc
    36661 gtatttaaga tctttggcaa atactttaaa gcctactaca caaattggta aagaaggtgt
    36721 tacagagagt ttcttagagc aattagatgg tatgttaaga actagagaat tagtaaaagt
    36781 tactatatta gaaaatgcag gtcttgatac taaagaaact gctaatgcag tatgtgaagc
    36841 tttaagagct gaatttgtgc aggctattgg ttttaaattt actatttaca agaggaatat
    36901 tgaagagcct aaaatacttt ttccaggaca tgaacaggcg aaagcaaaga ctaaaaataa
    36961 taatgttaca aaaaagggta aaccaactaa aagagctgtt agataatagt ttatatcctt
    37021 ttagggaaat aagttaaaaa aatagtgaca attggaagaa attgtattat actattaaac
    37081 ataaatttaa attagcaatc ttatcaagag tggcagaggg actggccctg tgaagcccgg
    37141 caaccagtat atttaattat acattggtgc taaatcctgc agcatttatg ctgaaagatg
    37201 agtataaacc cgtcatatgg cttgagttta tactcaagct ttttttattg gtatatttat
    37261 atatataaat aatttaatat aatcaaaatg atgggggtat gttacagtga agatagcaat
    37321 attagggtat ggaacagtag gaagtggatt aattgattta atagaaaata atacttcaaa
    37381 aagagatata gaagttgttg gaattttagt taaaaataaa gaaaaacaca agtataagaa
    37441 gtattttgat aagataacta ctgatataga agatatattt gacaaggata ttgatatact
    37501 agttgaagta attggaggat taaatccagc ttttgattat gtaacaagag cgttaaataa
    37561 aaaaatacat gtagtgacag ctaataaaga tttactggct gaaaaaggta gtgaccttat
    37621 agaattagct aacttaaata atgttagcat caagtttgaa gcatctgtgg caggtggtat
    37681 tccagtttta aaaccattga tagaatcact ggaaggcaac aatataaaga gcataaacgc
    37741 tattttaaat gggacttgta attttatatt atcaaagatg tatgatgaaa atttaccgta
    37801 tgatgtcgct ttaaaacagg cacaagagtt gggatttgca gaagttaatc cagatgcaga
    37861 tgttttagga tatgatagtg ctagaaagtt atctatattg tctactttat cttatggaaa
    37921 aatagtatat tggaaagatt tattattaga aggaataact tcaatagatg aaaaagatat
    37981 agaatatgca aaaaaattaa attgtaagat aaaattggtt gctagaagta agtatgaatc
    38041 aggagaagta agtggatttg ttagaccagc attagtggac aataataata tgctttcaaa
    38101 gatagataat gagttcaacg tagttatttt agtaggtgat tcagtaggtg aactttcttt
    38161 tgtaggtaag ggagctggaa gaggtgcaac aggaagtgct gtttatgcag atattataga
    38221 tataatagat aatagaagtt caaatataaa gtctttttca aaagggaaat tggatttaag
    38281 tggacttata gaagatgagt gtagtgcagt agttagattt ggtgggtata ataataaaga
    38341 tggaatttta gaatgtttag ataaatatgt agatagttat gatattatag atgatgaaga
    38401 attggcgatt tttgtaagtg caaagtcaga acatgagatt gatagagttt tggaaattgt
    38461 aaaaagaaat aattacagtg aatcagctaa aaaattattg aagatagatt aatatgttta
    38521 tgcaagaatt atgaaaattt aatagggtgt ctcaaaatag agagataagc cttttttcca
    38581 gtgttgaaat aataaaaata tatttgattt tataaaaaaa gagtgtctca tgaactaaaa
    38641 agttcatttt gagacactct tttttaatat ctggtgaatt aataagataa tagaaaaatg
    38701 tatacgttat aattaaccaa taaagaaatt ttcactagct tcattaatag cttgctgagt
    38761 tacccttata tatcgctgtg tagtggctac agagctgtga tttaaaagtt ctttaaccaa
    38821 ctctaaatta ttgttactct tttcaaattg agtagtagca tagagctttc taaagctatg
    38881 tgtacttata ttatacagat ttaagtattt acaaattatc ctcaactgtt tttgaatagc
    38941 ctttgtcttt atatttacta agtagtcatt tgatttaaga ttatactttc ttgcatgttc
    39001 atttatggac tcaattatat ttttattaac tggtctatac tgtaatttgc ccgtcttttt
    39061 ttcatttatt tccaacatat tacctttaaa attacctatc tttaatctta aaatatctga
    39121 tattcttaga cctaaattag cttctaacat tagtgccaat gcaactttag gattttttct
    39181 aaatcttttt tcaacgccat tttcactata agtaaagcca gtatgtaata gttccattat
    39241 ctttttatat tcgtctattt ctataggtct tgttgccatt ttcaaccact cctcttagtt
    39301 tgatttggta agtttaggtc ggtatttatt atataatata aatgaaatat tatataatgg
    39361 aaaaatttcc cagtaaactt atacaagtgt gatatatgtg attaaggaga attttttgaa
    39421 aaatatttct aataaaatta ttaaattgtg atgaaataac tatgctgtta aactaattaa
    39481 aaaggttatt aaaattatga caaatataat aaaaaaatgg aagtatttag ttaagtttta
    39541 ttagttttat ttttagtttt atttttttcg tgaaaatttc ttagtgaaaa aagtattttt
    39601 atatcgcatt agtttcccat ttgtagataa agttttcata tgtttttttg caataaatac
    39661 ggctgagatt agataaatta ttactacaat ttgaagaatt gtatcataat agctaagata
    39721 ataaaaccag attaaattat tatatataac gttgtatgta tcagcaaagc tagaaaccaa
    39781 cacagcagag tttgcaattg gataaagtat aaatataaag atagcagcta aaactccatg
    39841 cgcaaattta cttagtatgt ataattttaa atctatgtcc gtttttgata gaaatgtaca
    39901 acattgagct aggatggata atccactaaa tcctatcaaa aaactagcta aagatgctct
    39961 taaaatttct ggagaacttg ttatactaga tactttattg catcctatag taatttcaaa
    40021 tagaccactt acaaatgctt gacagagttc tttactaaca cctaaaaatg aaagaggcaa
    40081 atatataact gatgctatta atgagattac attaaaaaga gatagtattt taaatactac
    40141 tgaaaaaaca attacaaatc caccaactgt aagtaatgta tttactccat taaatacagc
    40201 atttccaaat aaaacaaaaa aaccattccc acttgaattt ctaatgttga ttacattttt
    40261 tatatttgtt tttaaatcca attttgtctt tggaagattt tcattaccat aatttctaaa
    40321 gaaaagacca accaatatag ttcctagata atggcagaga atcattaaat aacctaagtt
    40381 tgaattttgg aacatacctg taccaaccga acctattatg aataaaggtc ctgatgtaga
    40441 acaaaaagac acaagtcttt gtgcttcata cttagaaatt tgtccattac tcctaaattc
    40501 agaagctaaa cttactccta ctggataacc agatactgta gatatagcaa aagctaaagc
    40561 gctctttcct gaaacattaa atacaaatct agttatggga ttgatgataa accctataat
    40621 atccactatt tttaaatcaa caattaagtt tgctccaatt ataaatggta gtagtgatgg
    40681 aactaaaaca ttagaccata tagaaaagcc ttctcttgca gattttatag cttcatttgg
    40741 gtataggata atccctaaaa ctagaactcc aactatgata gatggagcaa aaaaagcaat
    40801 aattttattt tttttcataa tatcacctgt aaatttgagt tataagatat tatattaaaa
    40861 gtaataaaaa tatatgaatg taatggctta agatatataa tagatatata ttacaacaac
    40921 gattatcata ttggaggaaa aaatgtttaa tagtatagct agtaaaaaag tttatgaaca
    40981 agtaattgag caaatacaat ataaaatact aaatggagag ttaaaaaagg gggataaatt
    41041 actatcagaa agagaactgt ctgaacaaat gaatgtgagt agaacttcca taagggaagc
    41101 tattagggta ttagagacta tgggagtgat agaaagcaga cagggtgaag gaaattttat
    41161 atgtacaaat atagaaaaaa ctttaataga acctttatct atgattttta aacttaataa
    41221 tggtacactt gaagatatat tagagcttag aataatccta gaaattgaga ttgcaaaact
    41281 tgcttcaaag agaataactt cttctgaagt tatagaattg aaacatataa tagatgaaat
    41341 gagggtagaa actaataaaa aagataataa tcgagtactg gtgttattag accaaaaatt
    41401 tcacagtaaa ctagcaacat taagtaaaaa ttatttaatt caaagtcttt ttatgacagc
    41461 atcaaaatta tttgatggat ttatagaaga tgcaagagaa aaaataatcg cagaaccttt
    41521 taatgaaaat atattgctta aacagcatga agctatatac aatgcagttg tagaaaatga
    41581 tgtagaactt gcatgtgaga aagcaaagga acatatggat tttataagta aaaattatag
    41641 aaaaaatgaa aattaaaagt ttgttataaa ataaattatt cttgcaaatg gtagataatg
    41701 gtactatcat ataaatgtaa aactggtatg accacatacc aattttatag tttattataa
    41761 tgggagatta aaaatggtaa agttaaaagt accgtattca aaacaaggaa tgattttaga
    41821 aatacctgat gaacgttttc tcggtgtttt ggagtcaaaa tcggataatt atatagaaca
    41881 taagactcaa gaagagatag ttgaagaatc tatgaataat cctataggct ctaattctct
    41941 ggaagaactg gttaagggga aaaagaatgt agtcataatt acaagtgacc atacaagacc
    42001 tgtaccaagt agaataacta tgccaattat attaagaagg attaggaatg ttaatccaga
    42061 aattgatgtg aagattatag tggcaactgg atttcatagg ccaagtacaa gggaagagct
    42121 aatttataaa atgggagaag aaatagtaga taatgaagat atagttatgc atatatctac
    42181 tgatgataaa tctatgtgta aagtagggat attgccttca ggtggagatt tatatataaa
    42241 caaactagca tatgaggcag aacttttgat agcagaaggt tttatagaac ctcatttctt
    42301 tgcaggtttt tcaggtggca gaaaaagtgt acttccagga atcgcatctg caaagactat
    42361 aatgtacaat cattgtagtg actttataga tagtgataat tcaagaactg gaaaattgaa
    42421 taataatcct attcatgagg atatggtata tgcagctaaa gttgcaaaat tagcattcat
    42481 attgaatgtt gtaatagata aagataaaaa aataattgct tcctttgctg gtgatgtcga
    42541 aaaagcacat actaaaggat gtagatttgt aacagagtta tcaaaagtaa attctataaa
    42601 atctgatatt gttgtaacta caaatggtgg atatccacta gaccaaaata tttatcaatc
    42661 tgttaaagga atgacagcag ctgaagctac ttgtaaagac ggtggagtaa taataatgat
    42721 ttcagcatgt aatgatggtc atggaggtca atctttttat gaaaatgtag caaatgcaga
    42781 ttctccaaaa caacttttag ataaaattag aagtgtcgat agagtagata cgattccaga
    42841 ccaatgggaa tttcagatac tagcgagaat attatctaaa tatactgtga taatggtaac
    42901 agataagtgt aatcctgaaa tgataaaaaa aatgcatatg aaacatgcat ttaactttaa
    42961 agaagcttta gaaatggcga atagtatagt tggtaaggag agcaaagtag tagttatacc
    43021 tgatggagta tcagttatag ttaaataaaa aaggagtgta ctttatggaa attttgacat
    43081 gtattaaaca agttcctgga acgacttcag tagaagttga tgaaactaca ggagtactaa
    43141 aaagagatgg agtagattca aaaatgaatc cctatgacct atatgcttta gaaacagctc
    43201 ttagaataaa ggaagataag aaagcgaatc taaaagtact tagcatgggt cctcctcagg
    43261 caaagaaggt aattgaagaa agttttatga tgggagctga tgaaggagca ttaataagtg
    43321 ataggagatt tggaggagca gatgtattgg ctacttccta taccatatca caaggtatta
    43381 agaagatggg aaaggtagac ctaataattt gtggaaaaca aactactgat ggtgatacag
    43441 cacaggtggg acctgaagta gctgaatttt tagatatacc tcatgttact aacgttacaa
    43501 aattaattga agttaaagat gaaagtatag ttgttgaaat agatatgcca aatgatttac
    43561 aagtatgtga gattgaatat ccatgtttaa taactgtaga aaaagacatt tttcaaccaa
    43621 gactaccttc atttaaatta aaacttaata ctaaagatag agaaatacct gtatatagct
    43681 tagatgactt tgaagataaa gatgaaaata actatggact taatggttct cctactcaag
    43741 ttgtaagaat atttcctcca aagccaaata cagataaaaa tattgtaaga ggaaatgcag
    43801 atgaactaag ttttgcactt gtaaataaat tagaggaatt aaagttggtg taagggggag
    43861 taataaatgt caaagatagt tgtaaatcaa gataaaataa ctgacttaaa gagaatttta
    43921 gaaatatgtc cttttggggc tatagaagaa aagtcaggta tagtagaaat aagtgctggc
    43981 tgtaagatgt gcaagttgtg tgtcaaaagt ggaccaaaag gcgcatttga atttatagag
    44041 agtagtaaag tacaaattaa taaagatgaa tggaggggaa ttgcagtata tgttgaacat
    44101 cataatggaa atatacatcc tgtaacgtac gagcttatag gtaaagctcg tgagatggca
    44161 tcaaaaataa aacaacctgt gtattgtgta tttgtaggaa aagacataaa agataagtgc
    44221 agtaatttga tttcttatgg ggtggatgaa gtatttgtat atgatgaaga tgaatttaaa
    44281 gattttagga tagaaccata ttcaaaagca atagaaaact ttatagataa aataaaacca
    44341 acgatagtat tagttggtgg aactacatta ggtaggtcat tagctccaag acttgccgct
    44401 agatttagaa caggtcttac agcagattgt acaatacttg atattcaatc aaatactgat
    44461 ttagaccaaa taagaccagc atttggtgga aatataatgg ctcatataaa cacacctaat
    44521 aatagaccac aatttgccac tgtaagatat aaaatatttt cagcaccaga aaaaatagag
    44581 aatactacag gaaagataac tttatgtaaa gtagaaaaaa aagaactaaa atctaaaatt
    44641 aaggtactga gtgtaaaaga aaaaaataaa gaagttggtc tggaagaagc tgaagtgata
    44701 gttgtggcaa gtagagcaat aaaaaaacaa gaagatatgg agatgatata taaattagct
    44761 gataagttaa acgctcaagt ggcaggaaca agacctgtaa tagaagcagg ttggatagat
    44821 gctaaaaaac aaataggtct tagtggtaga actgtaaaac ctaaattgat aataacttgt
    44881 ggtgtatctg gagcagttca atttgttgca gggatgcagg gtgctgacta tatagtagca
    44941 ataaataaag atgataaagc gcctatactt gatgtagcac atttagcttt aataggtgat
    45001 atttatgata ttattcctaa attgattgaa aaaatagaaa ataacaaaga taataatcaa
    45061 aaatatatgg catcagcagc taaatagggg gatagaaatg tataaattaa tcgataaaaa
    45121 agatatagat tttttaatag atacttgtgg agaagaaaat gtattagttg gaagtgatat
    45181 aaatgaagat ttttcacatg atgaacttgg agggattgag aagtaccctg aagttttagt
    45241 aaatgtactt gaaactgaac aagtatctaa aataatgaaa tacgcatata aaaataatat
    45301 accagtcaca ccaagaggtc aaggtactgg tcttgtaggt gctgctgttg ccataaatgg
    45361 tggaataatg attaatctat gtaaaatgaa taaaatactt gaagttgatt atgaaaattt
    45421 aacattgaca gtagaaccag gtgttttatt gatgacaata ggtcaatatg ttcaagatag
    45481 agatttattt tacccacctg acccaggtga aaaaagtgct acaattgcag gtaatataaa
    45541 cactaatgca ggtggtatga gagcagtaaa atatggcgtt acaagggatt atgtaagagg
    45601 acttgaagtt gtactaccaa atggagaaat tataaatgta ggtggaaagg tggttaaaaa
    45661 tagttctgga tatagtataa aggatttatt agtgggctca gaaggtactt taggaatagt
    45721 tactaaagct atattaaaat tgcttccttt accaaagaaa agtataagtt tgcttatacc
    45781 atttccagat ttatcaatgg caatagaaac tgttcctaaa ataataaaat caaaatcaat
    45841 accaacggct atagaattta tggaaagaga tgtgatattg gcagcagaag aatttttagg
    45901 taaaaagttt ccagataata catcagatgc ttatcttttg cttacatttg atggaaatag
    45961 cactgaagat atagaaaaag aatatgaaaa agtagctaat ttatgtttag aaaatggtgc
    46021 attagatgta tttatatcag atacacaaga aagaaacgat tctatatggt cagccagagg
    46081 tgcattttta gaagctataa aggcatctac gacacaaatg gatgaatgtg atgtcgttgt
    46141 tccaagagat aagatagcag agtttataag atacactcac gagcttcaag acaaattaaa
    46201 aataagaata aaaagttttg gtcatgcagg agatggaaat ctacacatat atattttaaa
    46261 agatggtatg gatgataata catggaaaat aagattaaaa gaaacttttg actatatgta
    46321 taaaaaatct agagaactta gtggtcaagt ttctggtgaa catggcatag gatatgctaa
    46381 aaaagagtac ttacatgaat caaattcaga tgcttatatg atgttaatta aaaatataaa
    46441 gttagctttt gaccctaaaa atattttaaa
//
LOCUS       DAEHWM010000022        46457 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.023, whole genome shotgun sequence.
ACCESSION   DAEHWM010000022 DAEHWM010000000
VERSION     DAEHWM010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 46457)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46457)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46457
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.023"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            490..4038
                     /locus_tag="KNP36_001309"
     CDS             490..4038
                     /locus_tag="KNP36_001309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0873192.1"
                     /translation="MMNRLKPRILGISILFIIIIILTCGAVFKFKFKLDNKLKETTHT
                     YLSEFTEHNIINLKTRLSGQFDMLESIANFIGNLNNINDEMVIDLMDSDVKRSSLIRM
                     TISTLDGECYSNDGITHNVQDRDYFKKAKNGEKNISEPLKSIVNNKEIIVLSTPVYKS
                     GKIVGVLSGIYDSKKLNELLGLSAFDEKADVFVAKKNGDIVAQKTNKNRKTLSCIFQL
                     FDKDNCDEDDCLKTIKENMKNDKSGYFNYNLDNEKFMLNYQPLGVNDWYVFSVVPNKI
                     VSIQSENISYDVYIFALEILLVILIFIIYIACIINNNTKIIINEKEKFKVLTDNILGG
                     VKTCLKDEYMTMTYVSQGFLELTGYSCEDLNKIFKNRFKDMIYKDDLDKFNCIILNQL
                     EKQDKIEVEYRIVRKDGSIIWILERSKSINDNKGSECIQGVLTDITELKKIQEELDSK
                     RFEIQAINDSIVGGIVITEINDDFDSIYLNEGYLNMIGYTRKQLEDELNNKLIKLIFK
                     DDRTELINSINKQLKLSDTFASEQRVEKRDGTIIWILLKGRKMIYDNGKSVLCCVIVD
                     ITSAKLLEQELKKSEERHEIILKQTQNIIIEWDIEKDKMNISPNWYNKFKYDPITENA
                     TKNIIKSVDIYHDDMDKFISLIKLTSQGSEYEECEIRLRTRDTIYAWFSIKATTLFDN
                     NGKPYKVVGSLTDIDESKREAEKLKERAEKDPLTDLYNKKASQSLIEEYITLDKKRKG
                     ALMIIDIDDFKGINDNLGHLYGDAVLSEIANDLINLFRATDIVGRIGGDEFIVFIKDI
                     SETRDIINKAEELVKTFERSFLGKGRNYKISLSVGIAKFPQDGMDYMTLFRNADIALY
                     SAKGKGKNCYTLYDKKFDKVQYITNTRNAGDSDNVEMSFKEHITNYIFDILYESSDIE
                     VAVNLILSIVGKHFNVSRMYIFENSDDNRVCKNTFEWCNEGVTSEINNLKNICYKDLG
                     NYLLNFNADGLFYCNDIENLGSDVKKVLKPQGIRSILQCKILEGNEFRGFIGFDECSY
                     NRMWTNDEVNTLTFISKTLSMFLLKMRIQSKLEESLTIQKSVMDNMDIWAYVVDRNTY
                     ELLFINKKMLESAPNTHVGDLCYKAIWNNQDKPCKKCPMIYLKDGDDTYKSFMHNKKF
                     EVQANITTTTLKWFDGKDACLIFGSEITSIEAEENT"
     gene            4223..6157
                     /locus_tag="KNP36_001310"
     CDS             4223..6157
                     /locus_tag="KNP36_001310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgiQ family radical SAM protein"
                     /protein_id="HBF0873193.1"
                     /translation="MENKFLPISKQDMIDRGWEELDFVLVTGDAYVDHHSFGTAIISR
                     VLESAGYKVGIIAQPDWRTTDDFMKLGKPRLAFLVNAGNMDSMVNHYSVSKKHREKDM
                     YSPGGKMGYRPDRATIVYCNKIREAYSDVAIVIGGIEASLRRFAHYDYWSDKVRKSML
                     IDSGADLLVYGMSEKQIVEVANALNDGYDPKYIRHIDGTCYISDTLEEIYDKYILIPS
                     YKEICEDKMKYVEAFKIQYDEQDPFRGNIIVQPHGSKYLVQNKPEKPLSREELDEVYG
                     LPYQKTYHPVYEKFGGIPAIEEVKFSIVSSRGCFGSCSFCAITFHQGRAVQSRSEKSI
                     IDEAIGITNLDDFKGYIHDVGGPTANFRRPACKKQITKGACKNRQCLSPSPCKNLDAD
                     HSEYLHLLRAVRKLPKIKKVFVRSGIRYDYVMADKNNKFLRELIEHHVSGQLKVAPEH
                     ISEEVLKYMQKPAGKTYDKFRQKFFAINEELGKKQYLIPYLMSSHPGSTLNSAIELAE
                     YLRDTHYQPEQVQDFYPTPGTLSTTMFYTGIDPLTMKPVYVPKSKRDKAMQRALLQYR
                     APRNYDLVYSALVEAGREDLIGFGHRCLIKPKNEKPYFNRNNSKKNVSKGTNKNKKTN
                     TNNRSNKNQQKSSTKKKKKH"
     gene            6263..7258
                     /locus_tag="KNP36_001311"
     CDS             6263..7258
                     /locus_tag="KNP36_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0873194.1"
                     /translation="MKKYISIILLVVLTMVVLVGCSPGKDNPKNKELSVVKQVKVAVP
                     DGLPAVAIAKLANENPEIKEGYETVYSIEKTPEAISTRVMKKDADIAIVPSNMAAIAY
                     NKTSSYNIVGTVGMGSLYLVSTENIKDYSDLVGKEVGCTGKGLTPDITIKSLLLQKDI
                     NYSDIKFNYVNSASELVPLLATGKVKTGIVPEPALSALMSKNPDIKIIKSLNDSWKEV
                     SGSKDGYPQSTLIVKSEFLRDNKDFVDSFVGQLSNSIDWANKNPEELGAYSEKIKIST
                     ESKIIGKSLERANLKYIPVKDMIKDYKNYYEKLANFDDKTLGGKVPDEAIYFVEK"
     gene            7230..8015
                     /locus_tag="KNP36_001312"
     CDS             7230..8015
                     /locus_tag="KNP36_001312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBF0873195.1"
                     /translation="MKQYTLLRNKKNKEQFIDKMEVTLSCVILLFLWQIIALKIDNDI
                     FLPTVGQVFNSIKEIMLNSSFYIDILYSMGRCFFSFLLAMIFAIILSIVSYLNRFFRN
                     LLKPINALTRSIPTMILVVLALIWFEKDSTPFIVGFTIVFPILYDNVLGAILNIDKNL
                     LEMANVYKIRFIDKVLKIYLPAIKFQIISILVSTFSLSLKVAIAGEVYSQPTYGIGTM
                     IQTEKINFNTSGIFAWIIIVLLISAILQIAQKFLARRAFLWKR"
     gene            8003..8701
                     /locus_tag="KNP36_001313"
     CDS             8003..8701
                     /locus_tag="KNP36_001313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873196.1"
                     /translation="MEKIKLSIENINKRYDSRIIFRDFNIDFYVNEVNCILGKSGCGK
                     TTLLNIISGIIKNDTNNLNIKENLNRVGNKLEASYIFQDDRLIDWLTVEENIKIVVNK
                     YYNKTQLNKICDEYLELVGISDYKKFYPQMLSGGIRQRVNIARAFIYPSKNIIMDEPF
                     KSIDAKNTQLIMDNFRNILRKEKRTVLFVTHNIEEALFLADRIFILGDSPIRIKKILK
                     NSKELEKNEVLKLI"
     gene            8824..9297
                     /gene="ybaK"
                     /locus_tag="KNP36_001314"
     CDS             8824..9297
                     /gene="ybaK"
                     /locus_tag="KNP36_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-tRNA(Pro) deacylase"
                     /protein_id="HBF0873197.1"
                     /translation="MVKTNAMRILDSNKIDYKVMSYEVKSEHVDGVEVAHDIGRDVNE
                     VYKTLVTQGVSKNIYVYVIPVHENLDLKKAAKVAKEKSVEMIHVKDINKLTGYIRGGC
                     SPIGMKKFYKTFVNESAKNLDTIIVSAGKIGYQIELSPFDLQRLIKVEFVDVIKK"
     gene            9494..10333
                     /locus_tag="KNP36_001315"
     CDS             9494..10333
                     /locus_tag="KNP36_001315"
                     /EC_number="4.2.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarate hydratase"
                     /protein_id="HBF0873198.1"
                     /translation="MRKIKSEQIVEQVKKLCIEASLYLGEDVLSCIKEKAKSEKSEVG
                     KNILNILVENAEIAKEKNIPICQDTGMAVFFVEIGQEVLIEGDTLTDAINEGVRQGYE
                     EGYLRKSVVSPINRVNTKDNTPAVIHYDMVKGDKIKIEFAAKGFGSENMSKMKMLKPS
                     DGLEGIKKFIIDTVSEAGPNPCPPMVIGVGIGGTVDKCAQIAKKALFRELGEFNKDEN
                     IAKLESELLTAINKLGIGPQGLGGTTTALGLNIETFPTHIAGLPVVVNINCHASRHKN
                     VVI"
     gene            10346..10894
                     /locus_tag="KNP36_001316"
     CDS             10346..10894
                     /locus_tag="KNP36_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S-containing hydro-lyase"
                     /protein_id="HBF0873199.1"
                     /translation="MIKITTPVNEIDIAKLNCGDTISLSGILYTARDAAHKRLIDCIN
                     KGEELPFDVYGQGIYYVGPTPTKPGEVIGAAGPTTSYRMDDLTIPLLERGLRLMIGKG
                     KRSDEVIEGMQKYGAVYLAAIGGAGAYISNSIKSCEIIAYEDLGAEAIRKIVVEDLKL
                     TVAIDSYGNNIYEQGRAIYECK"
     gene            10960..12141
                     /locus_tag="KNP36_001317"
     CDS             10960..12141
                     /locus_tag="KNP36_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent malic enzyme"
                     /protein_id="HBF0873200.1"
                     /translation="MSKDYAKLALEMHEINKGKVSVESKVEIKTKDDLSTAYTPGVAE
                     PCLKIHENQDDVYRYTSKGNLVAVVSDGSAVLGLGNIGAEASIPVMEGKAILFKQFAD
                     VDAFPICLKTNDVDEIVKSVELMEPVFGGINLEDISSPRCFEIEERLKKSLSIPVFHD
                     DQHGTAIIVAAAIINSIKLIENKKIEDLEIVINGAGAAGIAIAKILLNMNVKNIILCD
                     RSGALEASIENLNYVQKEMLKVTNIRNEKGPLKDIIKGKDVFIGVSGPGAVTKEMVES
                     MSEKPIILAMANPTPEIMPEEAKLGGAFIMGTGRSDFPNQVNNVLAFPGIFRGALDVK
                     AKEINEEMKIAAAYAIANTISDEEICPEYILPDVFNKNVVKNVAKAVKEAAIKTKVNR
                     I"
     gene            12436..12822
                     /locus_tag="KNP36_001318"
     CDS             12436..12822
                     /locus_tag="KNP36_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009248914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0873201.1"
                     /translation="MEYKVNDQELNASMFIPFVNRIWPGDYDMDKTQTALSKTLNITA
                     YDDKVLVGCLRVLSDGYYFGTITELLVLPEYQKQGIGSKLFQLAKENTPTMLYFGAQP
                     GVEAFYEKNGCQRSLQSYIIKKKDSY"
     gene            12972..13235
                     /locus_tag="KNP36_001319"
     CDS             12972..13235
                     /locus_tag="KNP36_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0873202.1"
                     /translation="MEETKFCQCCAMPMGQTDELYGTNKDGSKSTDYCSYCFKDGEFT
                     ADISMEEMIEVCIPHMLQSNKDMTEDEARTMMNNFFPTLKRWK"
     gene            complement(13364..14206)
                     /locus_tag="KNP36_001320"
     CDS             complement(13364..14206)
                     /locus_tag="KNP36_001320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBF0873203.1"
                     /translation="MINIGDFNKLTVKRKTEFGYFLDGQTNNTKDDILLHNRLIGKNE
                     INIGDEVNAFIFKDSDDRTAATLIPPLAKVGDVAHLKVVDNTDIGTFIDMGLPKDILV
                     PFKAKTYPLFRDEKYLFYIYLDKSKRIAATTDIDSYLLTDHTYNVGDIVTGVVYGFQT
                     NNSAMICVDNKYAGVILHNEYFTELKTGDVLENLHVIKIYEDGKLGLSPRGNRKDELD
                     TLENKILSYLEGSDGYMRFNDKSDPKDISILFNSSKKNFKRALGVLMKKGLIYQDEEG
                     TYLK"
     gene            14501..15235
                     /locus_tag="KNP36_001321"
     CDS             14501..15235
                     /locus_tag="KNP36_001321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0873204.1"
                     /translation="MKIVNKSSNIPLHTQLSSIIREMIETGELKEGDAIMPERELCNI
                     QNVSRMTVNKTIVGLVTEGLLYRVQGKGTFVAKQKKKYQFSNVKGFTDVMKEKGVNIK
                     TDILSFEMELPDDLVKRKLGISDNTTNIYKIVRLRYTDGEPFGLEIVYLSEEMCKGLT
                     KGILDNSSLYRVLNEKYGYKIQKAEQVMEPVILSDEESKLLETDEGALALKLHRNSYN
                     REGSPIEYTISIFRTDKYQYEIVLSE"
     gene            15245..16378
                     /gene="nagA"
                     /locus_tag="KNP36_001322"
     CDS             15245..16378
                     /gene="nagA"
                     /locus_tag="KNP36_001322"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HBF0873205.1"
                     /translation="MKCLINGKIILKNQILENKVLVFDEKIIDIADSVPKDCEVIDAD
                     GKYISPGLIDIHIHGNMGKDTMDSTDESIETISKSIMRHGVTSFLPTTMTMDKEHVYD
                     ALEVIKKAQNRKLEGAQVLGAHLEGPFINENYKGAQNEKFIINSKYEFIKEYKDVIKV
                     ITYAPEKDIDFDFTREIKRCTDIVLSIGHSNANYDQAKEAINLGVTNVTHMFNAMTGL
                     NHRDPGVVGAALTTNVYSELIADTIHINKDLFQFILNNKGKERLILITDSIEAGGLED
                     GNYSLGGQKVIVKGNEARLENGALAGSVLSLNKMVFNFLDNTNLKVNEAINLASLNPA
                     TSLGINDKKGSLEIGKDADIAVFDENLDCKMTLCLGDVVYKNI"
     gene            16477..17226
                     /gene="nagB"
                     /locus_tag="KNP36_001323"
     CDS             16477..17226
                     /gene="nagB"
                     /locus_tag="KNP36_001323"
                     /EC_number="3.5.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012425552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HBF0873206.1"
                     /translation="MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMY
                     RDLVKKYNDNIVDFSDVMSFNLDEYYKLPISNDQSYDYFMKENLFNHVNIKPENTHLP
                     NGMADDIEKECMNYEASIDAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTES
                     TIEANARFFKSREDVPKKAVSMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEV
                     PGSILQLHKDTIVIVDEAAASKLNPKDYKLV"
     gene            17401..17673
                     /locus_tag="KNP36_001324"
     CDS             17401..17673
                     /locus_tag="KNP36_001324"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873207.1"
                     /translation="MLKIIMFSGILSSIIKLPIIGILPTGNIKKNTGISDSKKDGKQR
                     RSNLGISIYQLPSFLYSLINNSVPSNKPIPPEEIKLIKMYLLKSCI"
     gene            18333..19037
                     /locus_tag="KNP36_001325"
     CDS             18333..19037
                     /locus_tag="KNP36_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873208.1"
                     /translation="MSKLIYIADDEDNIRNLVKTFLKNEGHDVMDFKTGDELLEQFNI
                     KECDLVILDIMMPGSSGFEVCTKLREKSTVPIIMLTARDTDIDYITGITLGSDDYFTK
                     PFSPMSLVMRVKSIFRRIEFEKKQNYDKYSNSIDMELKFGDVIINKKNKIVTSKNVNI
                     DLTPNEYNLLTYLFENIDRAVSRDELLNKIWGYDIEVETRAADDTVKRLRKKILNTNI
                     LIETVWGFGFRLKEKS"
     gene            19039..20526
                     /locus_tag="KNP36_001326"
     CDS             19039..20526
                     /locus_tag="KNP36_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0873209.1"
                     /translation="MKNGNDKNRIGKIKSKFKLKFSKKNISIKTRILLSILCLIIIVF
                     MIILVSFNVFLDTYIKTTANEELTKSTEIVEHMDSNFRPIKPPQDDGKLPPKVLSNFM
                     RNVQDKVRMAETQSDADAMVVDSKYNLIFPTREDDFLKNVDEMELIRECIQNEKLDLN
                     SDENTRISTRNKDYYISTVKITSIYGEQDKYLILFIDISKTLNLAQKINIVLISVMCF
                     AGILAIFTAVILSEKIAKPIKELCEFVKKMGQGDFKRTYFDFSDKELVELSTVMNKSA
                     EYLDKYDNEQKIFFQNASHELRTPLMSIKGYAEAIKYNVIDSKHASDIILEESDRLSD
                     MVEDLLYISKIDNITKDFELVECDLREVLSNCGARQNVRAINKGIKFIYEFDEEMVLF
                     ECDEKNISKAFMNLIENALRYAKSEIKIVCKYNQKNIVVIIEDDGIGIKKEDLPHVFE
                     RFYKGVGGNHGIGLSIVKSIVNKHGGRIYVENGKKGAKFTILFKL"
     gene            20731..22344
                     /locus_tag="KNP36_001327"
     CDS             20731..22344
                     /locus_tag="KNP36_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0873210.1"
                     /translation="MKEQLIFNITNLVTVVFEAFVIHMFLSDFLGQKEGYIKVVRYAK
                     LGFIICLGFCNLITLNPKITMPLIFILIFSTSFLYKGNLKTRLFTTVLLSIFFILSEI
                     VVTSIFVLFVKEGFEIMLENNSIRVLATILSKIVFLLTCKIICLFKKDVHLDMPIKYW
                     LPLFLIPIFSLFLSVSIFDVSKFFSLESLKFLSLISSVGILYINFIVFYLFKFIIDKT
                     KLSMKYELLEKEIIHKEELRLSNECYKIIVEQTDSVVFEWNIKENKSFVSQAWTEKFG
                     YNNACKNIFKEIKDKDLVHSEDKAIFEGFLESIKKKNMHNQAVYRLKKSNGEYIWCRT
                     SITSIYNDENELLRVVGVIVDVDSDIKKYEELRTRAESDSLTNIYNKGTFEKLVEETI
                     VMNTGDKKDALFIIDLDDFKEINDNFGHPFGDFVLKTFADKIQTSFGSKDLVGRIGGD
                     EFVVYMQDYVTEVNLHKKAKELNRVLSDNYTDLSFSFDASVSIGIARYPQDGTSFFEL
                     FKNADRALYSIKASGKNSYCLFEEELYVQ"
     gene            complement(22707..23537)
                     /locus_tag="KNP36_001328"
     CDS             complement(22707..23537)
                     /locus_tag="KNP36_001328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0873211.1"
                     /translation="MSQVSKNYFTTGEFAKICGINKKTLFHYDDIGLFSPELKKENGY
                     RYYSYHQLSIFGIISSLREVKMPLKEIKAYIDKRTPNLLIELLEKKTIDIKNEIEKLN
                     NIQALMESTISFTKSACNIDANTITLKEHEEEYLVKTPVTYKEQFLGDEEENFLYECI
                     NFMDNYELSDYGTIGSIIKGEDIINKDFESYSYLFTKVNKEYKKYPVSIKPKGLYVTA
                     YHKGSYETIYKAYEKLLNFFNQNNLRIGDFVYEEYLLYDISVRDSNEYLTQISAEVKM
                     "
     gene            23610..25337
                     /locus_tag="KNP36_001329"
     CDS             23610..25337
                     /locus_tag="KNP36_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873212.1"
                     /translation="MKKLIHFLKPYRVLIVVVLIFTFLQTLGTLYIPTLTANIVNNGV
                     VKGDIDYIVKTGLMMMIVAGITALSAVLVCKVSANLSSGFCRDIREAVFIKSQDLSIN
                     DFNNIGTASMITRSTSDITLIGQSVFMFIQLVLPAPIITVSGLFLAYSIDKAMTIIIV
                     VVMFLFMLSAFLVGKKLIKLFKMMQIKMDNMNRVLREVVTGVRVIRAFNRSRFEKKRF
                     DRTAIDYSETAISINKIFAVLMPIVMLIMNLGIVSIIWFGGMRVSNGNMEIGHIMALV
                     EYCILILFYLIMGVMVFMYIPRAGACADRVNQILDIEPEIVDGNGHKDTVSERGHLVF
                     KNVTFSYAQSEEPVLNNITFEAKSGEVTAIIGSTGSGKSTIANIIPRFFEIQSGEISI
                     NGQDIKKIPQKELRDKIGFVPQKAFLFSGTIEENIRYGKEDASIEEVKHAASIAQADE
                     FIYDMEDKYDSFVAQGGNNLSGGQKQRISIARALVRKPEVYVFDDSFSALDFKTDKRL
                     RKALKNEIKDSSAIIIAQRISTIMDANQIIVLNDGKIVGIGKHKDLLENCEVYKQIAD
                     SQLSKEELA"
     gene            25374..27236
                     /locus_tag="KNP36_001330"
     CDS             25374..27236
                     /locus_tag="KNP36_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873213.1"
                     /translation="MSEKRIDEQDIEVLSFEDGMSAEKAKDAKKTTKRLLKYMAKQKF
                     KILIIFISVLISSALTVLAPMVMGKAIDQLFNGIKTAVQTGTKFSVNFSTMGGIVSIL
                     LGLYLISAVFIYIQQYIMSGVAQNLVLSMRKDLSDKLNKLPLKYYDSHKKGETLSIVT
                     NDLEKVADSLQEGLMQLITAVVTVVGSIVMMISISVPLTIVSAITLLVSLGITVVIAR
                     KSQERFSENQKALGELNSNIEEIFTGQIVVKAFSKEKDTIRNFKILNQNLYNASRKAQ
                     FSSYAISPIIRFINLIGYVIIAVVGGIFASTGAMTLGSIQAFIQYVNQASEPTTEISY
                     IVNMLQAAIASAERVFTVMDEVEEIKDEESSKVISMPKGKVQFEHVKFGYSDDFILMK
                     DININLNAGDKIAIVGPTGAGKTTLVNLLMRFYEIQGGRITIDGVNIKDLKRGELRTM
                     FGMVLQDTWLFNGSIKENIAYSKSDATMDEIVRAAKSARVDHFIRTLPQGYDTILTED
                     ASNLSQGQKQLLTIARAILSDPSVLILDEATSSVDTRTEVEIQKAMNNLMKGRTSFVI
                     AHRLSTIRDADLILVMKEGTIIEQGSHKELIEKKGFYEELYNSQFTSEYDEDVV"
     gene            27569..28258
                     /locus_tag="KNP36_001331"
     CDS             27569..28258
                     /locus_tag="KNP36_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyphosphate polymerase domain-containing
                     protein"
                     /protein_id="HBF0873214.1"
                     /translation="MNKKLNYRFEMKHKITEADVLALKSRLYPIMKKDENASKDGKYL
                     IRSLYFDTPEDKALLDKLNGVAIREKFRIRFYNNDCSYIRLEKKIKHYNMTSKLSTNL
                     TKKEVINILNNDIEFLKESTNCLLREFYLKLKCERLEAKSIVDYNREAFIYPVGNVRV
                     TIDSDIKTSVNSVDLFNKDLPTISVIDENMTVLEVKYDEFIPDFIKDLIQINKTTSTA
                     VSKYASSRLYI"
     gene            28363..29049
                     /locus_tag="KNP36_001332"
     CDS             28363..29049
                     /locus_tag="KNP36_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4956 domain-containing protein"
                     /protein_id="HBF0873215.1"
                     /translation="MILIMTFNDIFKSSFIENVSGFSFVDSALALGSAFLVGLFIYMV
                     YKKTYMGIMYSRPFNVSLVALTMLTTFVILAVTSNVVLSLGMVGALSIVRFRTAIKDP
                     MDLVFLFWSLGSGIVLGAGLIPLAVMGSIIMGLILIFFSNKTISETPYILMVNCNNED
                     SEDIATDKIKKVFTKYQIKSKSVTPEKGIELVFEVRMKDGETSLINDLSQVDGVTNAV
                     LVSYNGDYVA"
     gene            29066..30973
                     /locus_tag="KNP36_001333"
     CDS             29066..30973
                     /locus_tag="KNP36_001333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CotH kinase family protein"
                     /protein_id="HBF0873216.1"
                     /translation="MKDKKFTLLISIMIIFLCAVVGVYSTSSNKSADLYSDVYIEKYF
                     NRDKVMEVNIEIDESDLKDMNENAIKEEFKVAKVTVDGDTYGNVGIRTKGNSSLISVA
                     NSDSDRYSYKINFDKYNTSQSMEGLTQLNLNNCYSDPSYMREFLTYSICEEMGLATPE
                     FAYAKVSINGEYHGLYLAVEGLKESYLENNFGNVTGDLYKSDEGSSLQYKGDDPESYS
                     NLIVESDKKTADWSKITKLLKSLDTGEDIEKYLDVDSVLKNIAINTALLNLDSYQGSF
                     AHNYYLYEQDGVFSMLPWDFNMSFGGFSGFGGGSQSIAIDEPTTGNLEDRPLISSLLK
                     NETYKTKYHKYLEEIVTKYLDSDYLENMTTKLHDMIASYVKEDPTAFYTYEEFEKNIT
                     SSIEDSSDNKGFGNKGFDNNNSNNSDSNNNSNSENKRSGNQSDEKEVNAELTSSVVKA
                     NTDNETKNKTTNDSESKNNTDKDKSGNDNNQKLEGPMGKGGKSIPGVLEVAEDMSKTI
                     KSQLSGETSSTKQNSGDESSSGIKGSEKFDEDMSGMPEPPEGMDGKMPPGMGNMDKGD
                     MNGKNGNMNMDRNQDNPREAGGFGNRGGGSVSKTTTYFKLILGGASMIIMSIMLVGVS
                     RVKRRRFIKSK"
     gene            31426..32115
                     /locus_tag="KNP36_001334"
     CDS             31426..32115
                     /locus_tag="KNP36_001334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873217.1"
                     /translation="MLQKVLWKFLKLVVGLFICSVGIVLTINCNLGLSPWDVFHQGLS
                     NHIGITIGTASIIVGSIVVIADVVLGENVGWGTVFNMLLIGFFMDLLLYSNLIPEADS
                     LFVGIIMLILGLVLLSVGMVFYMGSGLGSGPRDGLMVAIQKKTGKSLKLIRGTIEVGA
                     LIVGFLLGGKVGIGTIISAFGLGYFTQMVFGLFKLDCSKIKHRFIVDDIKFIKVYMSG
                     EKKAAVQNIVK"
     gene            32551..33090
                     /locus_tag="KNP36_001335"
     CDS             32551..33090
                     /locus_tag="KNP36_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007286148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873218.1"
                     /translation="MDIGEKIKRLRTEKQLTQEELANRCELSKGFISQLENNLTSPSI
                     ATLIDILEILGTNLREFFNEIDDERISFTKEDMFETEDEDLKYKLKWLIPNSQKNEME
                     PIIITLYPGGQYKEEKPHEGEEFGYVLAGSIYVHIGEKKNKVKKGESFYFRPKANHYI
                     SNEGKTTAKVIWVSTPPSF"
     gene            33109..34152
                     /locus_tag="KNP36_001336"
     CDS             33109..34152
                     /locus_tag="KNP36_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873219.1"
                     /translation="MVENIIELRDISKHYEELTVLDNFNLDIKKNEFLTLLGPSGCGK
                     TTTLKIIAGFEYADDGKVLFEGKEINNLPPYERQVNTVFQKYALFPHMDVYENVAFGL
                     KIKKTPKDVIDAKVKEVLKLVALEGFERRQVESLSGGQQQRIAIARALVNEPKVLLLD
                     EPLGALDLKLRQEMQIELKRIQKKLGITFVFVTHDQEEALTMSDTIVVMYKGKIQQMG
                     TPQDIYNEPKNSFVAKFIGESNIFDGIMIEDYKVNFCNRDFECVDKGFEKNENIEVVI
                     RPEDIKMVKPEEGMLKGKVTSTVFKGVHYEIELNENGRLWILHNTKNAEVGTELGMDI
                     YPEDIHIMRKENN"
     gene            34154..34990
                     /locus_tag="KNP36_001337"
     CDS             34154..34990
                     /locus_tag="KNP36_001337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873220.1"
                     /translation="MKRKSFLAYPYVVWSAIFVIIPLILVVFFSFTKESGGGYAFTLE
                     NYKEVIDPIYMKVFGRSILLAGGATLICLIVGYPVAYIISKARVSRRGSLILLFILPM
                     WMNFLLRTYAWVAILGKNGLLNTFLGWFGIQPLAILYTNFAILLGMVYNFLPFMVLPI
                     YTALSKMDNDLINAAHDLGANNMTVFRKIIFPLSLPGVMSGITMVFMPAVTTFAISRL
                     LGGGKIMLVGDLIEQQFTVVGDWNFGSAISIFMMIVILISMSIMSKFGDESDKEGGGL
                     LF"
     gene            35095..35769
                     /locus_tag="KNP36_001338"
     CDS             35095..35769
                     /locus_tag="KNP36_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873221.1"
                     /translation="MARWNGFTWKWYGQLLQNESIMSALYYTIVIAILASVISTIVGT
                     ISAIGIHKMRGKSKKLILNVNYLPILNTEIVTAVALMSLFVFVKMEFGFTTMLLAHIM
                     FCLPYVILSVLPKMKQLPDNIEDAAMDLGATPIYALRKVILPQIKPGIVSGFLIAFTM
                     SIDDFIISFFNAGNGVSNLSIEIYGMARRGIKPEINALSTIMFAVVLGLLLLANKKES
                     IVRGIK"
     gene            35769..36821
                     /locus_tag="KNP36_001339"
     CDS             35769..36821
                     /locus_tag="KNP36_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spermidine/putrescine ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0873222.1"
                     /translation="MIKFKKAISLIAVGMMTVTLFTGCNKATDSTKVLNVYNVGDYID
                     ESLIDKFEKETGIDVQYSTYDTNEMMYQKVKSGSTHYDLVFPSDYMVEKMKNEGLLEK
                     LDFKNIPNMKYLDKSFLNPVYDKTNEYSVAYMWGTLGILYNKKEVKDPMDSWNILWNP
                     KYKGNIMMFDSVRDTIGITLKKLGYSMNSVNPKEINEAKNLLMKQKDLVLAYVNDEGK
                     DRLLGGEVAMGMLYSGDAVTLMEQNPDLDYAIPKEGTNKWVDAMCVPTTAQNKKEAEL
                     FINFLLDPENAKVNAEYIGYSTPNTGALKLLDPEITQNPVAYPSKEVLDKCETFEDIG
                     ENIKLYDKAWIELKSK"
     gene            37051..37899
                     /locus_tag="KNP36_001340"
     CDS             37051..37899
                     /locus_tag="KNP36_001340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0873223.1"
                     /translation="MNRINKKIDLLILALLVFIFLIVGIVILSIRTENKLNVFIMLAI
                     IFFIIMLTYLSNSVVGLITSSIIIFMYTSYILYNNITHNMDVEFISYMWIIATPVSSI
                     IMGNLNKSINELQNTNKKLSEQYKELVTIDSETGLRNLKIFYNDVNMEISKSIRHNTD
                     FSLMIVKLPYYGNLQTIFGENKTNKIVKYIGSNIIECTRNEDIIYSLQKDMIGILMPN
                     TSLEGSKVVKDRIKKRIKELNLDLNNRGKYVNIDVKIAFLQYKSSFGDSINFKNIVEE
                     ELQYDV"
     gene            37889..39553
                     /locus_tag="KNP36_001341"
     CDS             37889..39553
                     /locus_tag="KNP36_001341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0873224.1"
                     /translation="MMFKIFNKSLLKLVVVLSIVLTISNFSLSSYASEITSSTDKVLI
                     IYDSKKETAYNRDILNIMRTLLGRFSSDIELLKLSNYDGEINKNYYSHIFILGINENS
                     YNNDKNTKNLISSLNLYKGTICWLGYGIENLLEHKKYNLDYVGKTNNIVSVNYRGKSY
                     NLDEHYVFNIVESKDTSNKVIGSINDTLNKYPYIINDKNLFYVSKLDLDGVLFYIFCD
                     SLNDIFNIKTFDKGRIFVRIEDVHAFREPKNLVEIADYLSSKNIPFTIALIPAYVNPK
                     NHKVITLSESPEIVKAIKYMQDKGGTVILHGYTHQYKKEEVSGEGYEFWDGKKDEPLK
                     ENMKIFVKDRVLNGLRVCIENGIYPLAFEAPHYAMESEGYKELKKYFSTYIGQHQNND
                     KKFSTNTYPYIIRDTEEFNIFIPENLGYIDPEDKFTFQNIKENLDKLSIVRGFSGGFF
                     FHSYLNIEYLKNTIEYLEKQNIEFMNLRDFNNWVKVDEIQIRNNGDEIIVNYDKDLDE
                     LTKSDTRFKSISNISKVLIFIVSISVLIFVIIFIYFKRIDKKKFLK"
     gene            39602..40858
                     /locus_tag="KNP36_001342"
     CDS             39602..40858
                     /locus_tag="KNP36_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003362983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0873225.1"
                     /translation="MRDLNVSEYLFVFSLFSIWSLLLINIILAMGGYIFYFKNFDKEI
                     KEIDEYPMISILVPAHNEAKVIGRTVESLLLLNYPKSKMELIVINDNSSDNSKEILEN
                     IKDRYNNYNFTIINTDSLTGGKGKSNALNIGYTISKGDFIAVYDADNTPDKNALRYLV
                     QTIVMNDELGAVIGKFRTRNKNKNLLTKFINIETLSFQWMSQAGRWQLFNLCTIPGTN
                     FILRRSIIEEIGGWDSKAIAEDTEISFRIYKLGYKIKLVPQSITWEQEPETVKVWIKQ
                     RTRWAKGNIYVLMKYIKNIFKQGRNKIVFDIAYFFSVYFLFLTSVIISDILFVLSISK
                     LVEISIPINFFLIWILSYLLFIIEVSISLTIEKGEATIENIFIVAIMYFTYSQLWLFV
                     AIKGMIEYLKDIIFKREVKWYKTERF"
     gene            40881..42962
                     /locus_tag="KNP36_001343"
     CDS             40881..42962
                     /locus_tag="KNP36_001343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cellulose biosynthesis cyclic di-GMP-binding
                     regulatory protein BcsB"
                     /protein_id="HBF0873226.1"
                     /translation="MKKFIISIISLVLFFSNISLIYKVNADETKVKNYKFERDITIDG
                     VIGSNSTFFEVNKNWDIEEVLLHLNFSKSQILNGDVSSLTVLINNVPIKSIKLNAKTN
                     YKNTLEVLVPKDYIIQGYNEIKIKTYKTISDKICQDDSNTGNWMVIHKESYISIRYKQ
                     KKVENSINEYPYPYAEIENNHKLDTTIVVPDNMTRGETTAVFNLASAFGKITKNDDLK
                     LDVKLYSEMKNWSDDNIIYIGKPENTAEEILDILSIKEQTLLSSNCIIKQVDSPYNKN
                     KKMMVVIGSNEDDLIKASNLLIENRLSNQVLSSSVLVNKETNIKINREQKLNLGHLTL
                     KDLGYSDFLLEGAFNQQALFDVKIPTGKVLDDGSKIILNLRYSDNLDFEKSLVTVSIN
                     DVIVGSKKLDRSHSNNDKLELKIPKDIDNKNYYQVKLTFNLSIKNSNCVTRESNNPWA
                     YVSNNSYLALSTKENETLSFENYPYPFVRDDEFNDLTVIMPDYSGSQAMTWMFRLGVT
                     LGANINSHNGNINVIRGKEFSDKYKDTNIVVFGVPHNNSVIKMLNNNLNIKFDKNYSN
                     FISNDKISFIDDYGKNISTIQLIKSPYNNQKNIMVISSMNEKNLYLGMDYLLNKSKVN
                     DLKGDTLIIDEYGEVEDLAYNLKSKKEVKDSSWNMSINKTTKVFLMISFITIIIVMIL
                     SMLYIKKYKRR"
     gene            42999..44084
                     /locus_tag="KNP36_001344"
     CDS             42999..44084
                     /locus_tag="KNP36_001344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBF0873227.1"
                     /translation="MRKYMNEFKLKRSILISLIILIFIFIVYFVSIELKDRSLVNNQY
                     KGKIKSANLSVDYEINQVMKDIDKLGLNTVNVPIIINVESINSDIMSIDNNSKEKAIK
                     LIKKLNKKGISTILEAYPWIENGKLYETDWNPINKKRFFYTWQNAILNELIIDVANPL
                     DVNVLNIGSNFVHLEEYQQNWGEIIDFVQSKFDGLVTYRTNWWYTKKDDLSSKLFYEQ
                     KLNNNFFDKLDFISIAAYFELSNKPVNTVDELISALHSSTVNNRGQNIKQEIYNLYKA
                     HRKPIFFGELGFSNRESASSQPWNHTPSKAVNGEEQARCFEAYKKVFENEDWINGFSV
                     FCVGKIDDEKNFYPSKESIKVIKSWYE"
     gene            44138..45262
                     /gene="wecB"
                     /locus_tag="KNP36_001345"
     CDS             44138..45262
                     /gene="wecB"
                     /locus_tag="KNP36_001345"
                     /EC_number="5.1.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 2-epimerase
                     (non-hydrolyzing)"
                     /protein_id="HBF0873228.1"
                     /translation="MNDIKVMTVFGTRPEAIKVAPLIKELEKRENIKSIVCVTAQHRE
                     MLDQVIETFNINVDYDLDIMEKGQSLNDITCKILNKLPLILNKENPNIILVHGDTTTT
                     LATSLTAFYNKTLVGHIEAGLRTYDKYSPFPEELNRQLTGIIADMHFAPTNLARKNLI
                     SEGKPNNNIFVTGNTAIDALKMTIKENYNHPIIDEIGNDRMILLTSHRRENLGKPMKN
                     IFRAIKRIVDDFEDVQIVYPIHLNPKIRTIADEIFGKFPEKIHIIEPLDVADFHNFLN
                     KSYMIMTDSGGIQEEAPSLGKPVLVLRDKTERTEGIEAKTLKLVGTNEDRIYNSVSDL
                     LINKDNYVQMSKASNPYGDGNASKYIVDIIIKKFNCKYLN"
     gene            45340..46314
                     /locus_tag="KNP36_001346"
     CDS             45340..46314
                     /locus_tag="KNP36_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBF0873229.1"
                     /translation="MARKLIKNLGKSKSVKRVKLLFKKIFITVFIVASIVAIFNITKY
                     FEELYKVRDLKSTKIEYYMDVADEAGDGKVQLSWKALLAIDMVIHDEDLSNIKKKDTL
                     DIGEKFIVEDKNGKGEKVYKVKKFNKVLSELKFDSSQKSRARKYMKDLEYTYLGNKQL
                     DSSDEKIKFIKKLEDSAIREYIDYGILPSITIGQAILESGWGNSKLTKQSNNLFGIKA
                     DKAWKGKSVEISTSEHYNEKIVASFRSYNSLQDSVKDHSLFLINNKRYRKHGLFEAKD
                     YISQAQALENAGYSTAEDKKGNRIYAELLIDVIRSYNLQLIDNKVETK"
BASE COUNT        18542 a         4689 c         8038 g        15188 t
ORIGIN      
        1 taaaaataaa atagtaaaag gatattataa tattttacta gaattattat ctggtaactt
       61 aagttttgag tattaatcta aagtatatgt ttttatatgg tttaaatttt atgtatacaa
      121 aattaatttg ctaactgaat catataaaaa aaaacaaaat attttttaga gggaatgatt
      181 agatagaatt tttttgttat gaaattaatt gaagagtaat taattagaaa aggaatgaat
      241 aataatgaat atattacatt attacttttt gataaatcaa aaataaagtt ataattttta
      301 atattaatta agaatgatga aatatgaata aagattttac aaataaatct taagctatct
      361 tatttaattc taatacagga agaaggtaaa tgtatattga aaaaatcata gaaatagaag
      421 taaacaattt aaataaatac aaaggtttgc aaaagaagta atataattat atacaatgag
      481 gatgtgagta tgatgaacag actaaagcca agaattttag gtattagtat cttgtttatt
      541 attataatta ttttaacatg tggagctgtt ttcaagttta aatttaaatt agataataaa
      601 ttaaaagaaa ccacacatac atatttgtct gagtttacag aacacaatat aattaatctc
      661 aagacaagac ttagtggtca atttgacatg cttgaatcta ttgctaactt cataggaaac
      721 ttgaataata taaatgatga aatggtgatt gatttaatgg attctgatgt aaagcgaagt
      781 tctttaatta gaatgactat ctctacatta gatggggaat gttattctaa tgatggaatt
      841 acccataatg ttcaagatag agattatttt aaaaaagcta aaaatggaga aaagaatata
      901 tcagagcctt taaaatctat tgttaataat aaagaaataa tagttttatc taccccagtt
      961 tataaaagtg ggaaaatagt tggtgtttta agtggaattt atgattcaaa aaagttaaat
     1021 gagttattag gattatctgc atttgatgaa aaagcagatg tttttgttgc aaagaaaaat
     1081 ggagatatag ttgctcaaaa aacaaataaa aatagaaaga cgctatcatg tatatttcag
     1141 ctttttgaca aagataattg tgatgaagat gattgtctaa aaactataaa agaaaatatg
     1201 aaaaatgata agtctggata ttttaattat aacttagata atgaaaaatt tatgttaaac
     1261 tatcagccac ttggagttaa tgattggtat gttttttctg ttgtgccaaa taaaatagta
     1321 tctattcagt cagagaatat atcttatgat gtatatattt ttgcattaga aatactacta
     1381 gttatattga tttttataat atatatagca tgtattataa ataataacac caaaattatt
     1441 ataaatgaaa aagaaaaatt taaagtactc actgataata tattaggagg ggttaaaacc
     1501 tgtttaaaag atgaatatat gactatgaca tatgtaagtc aggggttttt agagcttaca
     1561 ggttactctt gtgaagattt aaataaaata tttaaaaata gatttaaaga catgatttat
     1621 aaagatgatt tagacaagtt taattgtatt attctaaatc aattagaaaa acaagataaa
     1681 attgaagttg aatatagaat tgtaagaaaa gatggaagta taatttggat tttggagaga
     1741 agtaagtcta taaatgataa taaaggaagt gagtgtattc agggagtttt aactgatata
     1801 acagaactta agaaaataca agaagaatta gattcaaaaa gatttgaaat acaggctatc
     1861 aatgatagta ttgttggtgg aatagtgata actgagataa atgatgattt tgatagtata
     1921 tatttaaatg aaggttattt aaatatgatt ggatatacac gcaaacaact ggaagatgag
     1981 ctaaataata aattaatcaa acttattttt aaagatgata gaacagaatt aattaatagt
     2041 ataaacaaac aactcaaatt aagtgataca tttgcatctg aacaaagagt tgaaaaaagg
     2101 gatggcacta ttatatggat tttattaaaa ggaagaaaga tgatttatga taatggaaaa
     2161 tctgtacttt gttgtgttat tgtagatatt acttctgcta aattattaga gcaagaactt
     2221 aaaaagagtg aagaacgtca tgaaatcatt ctaaagcaga cgcaaaatat tataatagaa
     2281 tgggatatag aaaaagataa aatgaatata tcacctaatt ggtataataa gtttaaatat
     2341 gaccctataa ctgaaaacgc aacaaaaaat ataattaaat cagtagatat atatcatgat
     2401 gatatggata agtttatttc attaattaaa cttacttcac aaggtagtga gtatgaagag
     2461 tgtgaaatta gacttagaac tagagatact atttacgctt ggtttagtat aaaggcaaca
     2521 actttatttg ataataatgg taaaccttat aaagtagtag gaagtttgac tgatattgat
     2581 gaatcaaaac gagaagctga aaagttgaaa gaaagggcag aaaaagaccc tcttacagat
     2641 ctgtataata aaaaagcatc acaatcactt atagaggagt acataacatt ggataaaaaa
     2701 agaaaaggtg ctttaatgat tattgatatt gatgacttta aaggaataaa tgataattta
     2761 ggacatttat atggggatgc tgtattaagt gaaattgcaa atgacctaat aaatctattt
     2821 agagcaaccg atatagtagg cagaattggt ggagatgagt ttattgtatt tataaaagat
     2881 atttctgaaa caagagatat tataaataaa gcagaagaat tggtaaaaac atttgaaagg
     2941 tcttttttag gtaaaggacg aaattataaa atatcattaa gtgtaggaat tgctaagttt
     3001 ccacaagatg gtatggacta tatgacacta tttagaaatg cggatatagc tctttactca
     3061 gccaaaggga agggcaagaa ttgttataca ttgtatgata aaaaatttga taaagtccaa
     3121 tatataacta atacaagaaa tgcaggagat agtgataatg tagagatgtc ttttaaagaa
     3181 catatcacaa attatatatt tgatatacta tatgaatcaa gtgatataga agtggcagta
     3241 aatttaattc taagtattgt aggtaaacac tttaatgtga gtcgcatgta tatatttgaa
     3301 aattcagatg ataatcgagt atgtaaaaat acatttgaat ggtgtaacga aggtgtaacc
     3361 tcggaaatta ataatcttaa aaatatttgt tacaaggatt taggcaacta tcttttaaat
     3421 tttaatgcag atgggttatt ttattgtaat gatattgaaa atttaggtag tgatgtgaaa
     3481 aaagtactta agccacaagg catacgttca atattacaat gtaaaatttt agagggtaat
     3541 gaatttagag ggttcatagg atttgatgaa tgttcatata atcgtatgtg gactaatgat
     3601 gaagtgaaca ctttgacatt tatatctaaa acgctcagta tgtttttatt aaaaatgcgt
     3661 attcagagta agctagaaga gtctttaaca attcaaaaat ctgtgatgga taatatggat
     3721 atatgggcat atgttgttga caggaatacc tatgaattac tatttatcaa taaaaaaatg
     3781 cttgagtcag caccaaacac tcatgtaggt gatttatgtt ataaagcgat atggaataat
     3841 caagataaac cttgtaaaaa atgccctatg atatatttaa aagatggtga tgatacttat
     3901 aaatcattca tgcataataa aaagtttgag gtacaggcaa atataactac aactactttg
     3961 aaatggtttg atggtaaaga tgcatgttta atatttggaa gtgaaataac tagtattgaa
     4021 gctgaagaaa atacttaaaa tactgtgtta tatatatact taaaatcgca atttgaattt
     4081 attagactta aaatgtctat ataaatcatt taagttgtgg ttttaagtat tttttatgat
     4141 ataattaagc gttaagaaca aaattaaaag atacttttgt ataaaaaaat atttgttaaa
     4201 tatatattga gcaggtgata atatggaaaa taagttttta ccaataagca aacaagatat
     4261 gatagataga ggatgggaag aattagattt tgttctagtt acaggagatg cttatgtgga
     4321 ccatcatagt tttggaacag caataatatc tagagtttta gaaagtgctg ggtataaagt
     4381 tggaataata gctcaaccag actggagaac tacagatgat tttatgaagc taggaaaacc
     4441 tagacttgca tttctagtta atgcaggaaa tatggattca atggtcaatc attattctgt
     4501 aagtaaaaag catagagaaa aggatatgta ttctccaggt gggaaaatgg gttatagacc
     4561 agatagagct actatagtat attgcaataa aataagagaa gcatacagtg atgttgcaat
     4621 agtaataggt ggaattgaag cgagcttaag aagatttgca cactatgatt attggagtga
     4681 taaggttaga aagtctatgt taatagatag tggagcagat ttattagttt atggtatgag
     4741 tgaaaagcag attgtagaag tagccaatgc acttaatgat ggatatgacc caaaatacat
     4801 tagacatatt gatgggacat gctatatttc agatacattg gaagaaatat atgataaata
     4861 tatattaatt ccatcatata aagaaatttg tgaagataaa atgaagtatg tagaagcttt
     4921 taaaattcaa tatgatgagc aagacccatt tagaggtaat ataattgttc aacctcatgg
     4981 aagtaagtat ctggttcaaa ataagccaga aaaaccactt agtagagaag aattagatga
     5041 agtatatgga ttaccatatc agaagacata ccatcctgta tatgaaaaat ttggaggaat
     5101 accagctata gaagaagtaa aatttagtat agtaagttca agaggctgtt ttggtagttg
     5161 ttcattttgt gcaataacat ttcatcaagg tagagcagtg caaagtagaa gtgaaaaatc
     5221 aattattgat gaagcaatag gaataacaaa tttagatgat tttaaagggt atatacatga
     5281 tgttggaggt ccaacagcta attttagaag accagcatgt aaaaaacaaa ttactaaagg
     5341 tgcttgtaaa aatagacaat gcttatctcc atcaccatgt aaaaatttag atgcagacca
     5401 cagtgaatac ttacatttac ttagagctgt aagaaaatta cctaaaataa aaaaggtgtt
     5461 tgtgcgttct ggaattagat acgattatgt aatggcagat aagaacaata aatttcttag
     5521 agagttgata gagcatcatg taagtggtca gttaaaggta gccccagaac atatatcaga
     5581 agaagtttta aagtatatgc aaaaaccagc aggaaaaact tatgataaat ttagacagaa
     5641 gttttttgct ataaatgaag aattaggtaa aaagcaatat ttgataccct atttaatgtc
     5701 tagtcaccct ggttctacct taaatagcgc tatagagtta gcagagtatt taagagatac
     5761 tcactaccaa ccagagcagg ttcaggattt ttatccaact ccagggactc tatctacaac
     5821 catgttttat acaggtattg acccgcttac aatgaagcca gtttatgttc ctaaatcaaa
     5881 acgtgacaag gcaatgcaaa gggctttatt acaatataga gcacctagaa attatgattt
     5941 ggtatactct gcgttagttg aagcaggaag agaagactta attggttttg gacatagatg
     6001 tcttataaag ccaaaaaatg aaaagcctta ttttaataga aataattcta aaaaaaatgt
     6061 atctaaagga acaaataaaa acaaaaaaac taatacaaat aacagaagta ataaaaatca
     6121 acaaaaaagt tcaactaaaa aaaagaaaaa acattaaagt ataaataaaa atacttaaaa
     6181 aagaaggatt attcgataaa ttaacagaaa ttagtataaa taaatataat tattttaatg
     6241 acgttacctt tgggaggaag agatgaaaaa gtatatttct ataatattat tagtggtgtt
     6301 gactatggtt gttttggtag gatgttcacc aggaaaagat aaccctaaaa ataaggagct
     6361 atcagttgtc aaacaagtaa aagtagctgt tccagatgga ctaccagcag tggcaatagc
     6421 taaacttgca aatgaaaatc cagagattaa agaaggatat gaaacagtgt atagcattga
     6481 aaagacacct gaagcgattt ccactagagt gatgaaaaaa gatgcagata tagctatagt
     6541 tccttcaaac atggctgcaa tagcgtataa taaaacttca tcatataata ttgttggaac
     6601 tgtaggaatg ggttcacttt atttggtgtc aacagaaaat ataaaagatt actctgattt
     6661 agttggtaaa gaagttggat gtactggaaa aggacttact ccagacataa ctataaaaag
     6721 tcttttgtta caaaaggata taaattattc agatataaaa tttaattatg taaattcagc
     6781 aagtgaactg gtaccattat tggctactgg taaagttaaa acaggtattg ttccagaacc
     6841 tgcacttagt gctttgatgt ctaaaaatcc agacataaaa attataaaaa gtttaaatga
     6901 ctcatggaag gaagtaagtg gttcaaaaga tggttatcct caatctactt taattgtaaa
     6961 gtctgaattt ttaagagata ataaagattt tgttgattct tttgtaggtc aattatcaaa
     7021 tagtatagat tgggcaaaca aaaatcctga agaattaggt gcatattctg aaaaaataaa
     7081 aatatctact gaatcaaaga taataggaaa atctcttgaa agagctaatt tgaaatatat
     7141 tccagttaag gacatgatta aagattataa aaattactat gagaaattag ctaattttga
     7201 tgataagaca ttaggaggca aagtaccaga tgaagcaata tactttgttg agaaataaaa
     7261 aaaataaaga acaatttata gataaaatgg aggtaacact ttcttgtgtt atcctcttat
     7321 ttttatggca aattattgct ttaaaaattg ataatgatat ttttttacca acagtaggtc
     7381 aagtgtttaa tagtataaaa gagattatgc taaattctag tttctatata gatatacttt
     7441 actctatggg gagatgtttt tttagttttt tactggctat gatttttgct attatacttt
     7501 caatagtgtc ttatttaaat agatttttta gaaacttatt aaagccaatc aatgctttga
     7561 cacgttcaat accaactatg atattggtag tacttgcact tatttggttt gaaaaggata
     7621 gtaccccttt tatagttgga tttactatag tttttcctat attgtatgat aacgttttgg
     7681 gcgctatatt gaatatagac aagaacttat tagaaatggc taatgtgtat aaaataaggt
     7741 ttatagataa ggtgttaaaa atttatttac cagccataaa atttcaaatt atatctatac
     7801 tagtatcaac attttcttta agtttgaaag ttgctatagc aggagaggtg tatagtcaac
     7861 ctacatatgg tattggaact atgatacaga ctgaaaaaat taactttaac acatctggaa
     7921 tatttgcatg gataattatt gttcttttaa tatctgctat tttacaaata gctcaaaagt
     7981 ttttagcaag gagagctttt ttatggaaaa gataaagttg agtattgaaa atataaataa
     8041 aagatatgat agtcgtatta tatttagaga ttttaatatt gatttttatg taaatgaggt
     8101 aaattgtatc cttggaaaat ctggttgtgg aaaaactaca ctcttgaaca taataagtgg
     8161 gattattaaa aatgacacca acaatctaaa tatcaaagaa aatttaaata gagtaggaaa
     8221 taagcttgaa gctagttaca tatttcaaga tgatagactt atagactggt taacagtaga
     8281 agaaaatata aagatagttg taaataaata ctataataaa actcaattaa ataaaatttg
     8341 tgatgaatac ttggaattgg ttggaattag tgattataaa aaattctatc ctcaaatgct
     8401 tagtggaggt attagacaaa gagtaaatat tgctagagct tttatatatc catcaaaaaa
     8461 cattataatg gatgaacctt ttaaatctat tgatgcaaag aatacacagc ttataatgga
     8521 taattttaga aatatattaa gaaaagaaaa gagaactgtg ttatttgtaa ctcataatat
     8581 tgaggaagca ttgtttttag cagataggat atttatttta ggagactctc caattagaat
     8641 aaaaaaaata ttaaaaaatt ctaaggaatt ggaaaaaaat gaagttttga agttgatata
     8701 gagttataat aatactgtcg ttttaaaata tatttggtta aaatctataa gactatatta
     8761 aaatagtaca gaatattcaa aactgtgtat aatgttcgta ttttataaaa aggaagtgaa
     8821 tgtatggtta agactaatgc tatgagaata ttagattcaa ataagattga ttataaagta
     8881 atgtcttatg aagtgaaaag tgaacatgtg gatggtgttg aggtggcaca tgatatagga
     8941 agagatgtaa atgaagtgta taagacatta gtaactcaag gagttagtaa gaatatatat
     9001 gtatatgtaa taccagtaca tgaaaactta gacttaaaaa aggctgcaaa agtagctaaa
     9061 gagaaaagtg tagagatgat tcatgtaaaa gatataaata agcttacagg ttatattaga
     9121 ggcggatgtt ctcctatagg tatgaaaaag ttttataaaa cttttgtaaa tgaaagtgca
     9181 aagaatttag atacaattat tgtgagtgca ggaaaaatag gatatcaaat agaactatct
     9241 ccatttgatt tacaaagact tataaaagta gaatttgtag atgtaataaa aaaataagaa
     9301 ttacatataa aatatagagc ttatattctc aataataggt gttgtaatat taataaaatg
     9361 aataagaatt ttaaaataaa tattcagtta cttatgtgta attggtataa aaatattgag
     9421 aaattttaaa aacaatggta aagtgtaagt ataatcacga atatttttta taaagtaatg
     9481 gagggatgtt cgcttgagaa aaataaaatc tgaacaaatc gtcgagcagg taaaaaaact
     9541 ttgtatagaa gcgagcctat atttaggaga agatgtttta agttgtataa aagaaaaagc
     9601 gaaaagcgaa aagagtgaag ttggaaaaaa tatattgaat atattagttg aaaatgctga
     9661 aatagctaaa gaaaaaaata taccaatatg ccaagatact ggtatggctg tattttttgt
     9721 tgaaatagga caagaagttt taattgaagg agacacactt actgatgcta taaatgaggg
     9781 agtaagacaa gggtatgaag aaggctactt aagaaaatct gttgtaagtc caattaacag
     9841 agtaaataca aaagataata cacctgctgt tattcattat gatatggtaa aaggtgataa
     9901 aattaaaata gaatttgcag ctaagggatt tggaagcgaa aatatgagta agatgaaaat
     9961 gttaaagcca tcagatggat tggaaggaat taaaaaattc ataatagata cagtttcaga
    10021 agctggacct aacccatgcc ctcctatggt aattggagtt ggtataggtg ggactgtgga
    10081 caaatgtgct caaatagcta aaaaggcact ttttagagaa ctaggtgaat ttaataagga
    10141 cgaaaatata gcaaaacttg aaagtgaact attaacagct attaataaac ttggtatagg
    10201 acctcaaggc ttaggtggta ctacaacagc tttgggatta aacatagaga cttttcctac
    10261 acacatagca ggtctacctg ttgttgtaaa tataaactgc catgcatcaa gacataagaa
    10321 tgtagtaatt taggaggaaa ataaaatgat aaaaataact acacctgtaa atgaaattga
    10381 tatagcaaaa ttaaattgtg gagatacaat tagtttgagt ggtatacttt atacagcaag
    10441 agatgctgct cataaaagat tgatagattg tataaataaa ggtgaagaat taccatttga
    10501 cgtatatggt caaggaatat attatgtagg acctactcct acaaagccag gagaagttat
    10561 aggtgctgca ggtccaacga cgagttatag aatggatgat ttgactatac ctcttttaga
    10621 aagaggtctt agattgatga taggcaaggg aaaaagaagt gatgaagtta tagaaggtat
    10681 gcaaaaatac ggagcagttt atcttgctgc aataggagga gctggagcgt atatttcaaa
    10741 ttcaataaaa tcatgtgaaa ttattgcata tgaagattta ggagctgaag ctataagaaa
    10801 gattgtagta gaagacctta agcttacagt agcaatagat agctatggaa ataatatata
    10861 tgagcaaggt cgagcaattt atgaatgtaa ataatgttta gaaataaata tgaatatcaa
    10921 aattaaaaat agttgtgtat attttaagga ggaaaattga tgtctaagga ttatgcaaaa
    10981 ttggcattag aaatgcatga aatcaacaaa gggaaagtaa gtgtagaaag caaggtagaa
    11041 attaaaacta aggatgattt atcaacagca tatacaccag gggttgctga accttgttta
    11101 aaaatacatg aaaatcaaga tgatgtttat agatacactt ctaaagggaa tctagtagca
    11161 gtagttagtg atggaagtgc tgtacttgga ttaggtaaca ttggtgctga agcatctata
    11221 cctgttatgg aaggtaaagc tatattattt aaacaatttg cagatgtaga cgcttttcca
    11281 atatgtttaa agactaatga tgtagatgag atagttaaat ctgtagagtt gatggagcct
    11341 gtatttggag gtataaattt ggaagacata tcttctccaa gatgttttga gatagaagag
    11401 agattaaaaa aatctttaag tatacctgtt tttcatgatg accaacatgg gacagcaata
    11461 atagttgcag ccgccataat aaactcaata aagttaattg aaaataaaaa aatagaagat
    11521 ttagaaatag ttataaacgg agcaggagct gctggtatag ccatagcaaa gatactactt
    11581 aatatgaatg ttaaaaatat aatcttatgt gatagaagtg gagcattgga agctagtata
    11641 gaaaatctaa actatgttca aaaagaaatg ttaaaagtaa caaatataag aaatgaaaaa
    11701 ggacctttaa aagatattat aaaaggaaaa gatgtattta ttggtgtttc aggtccagga
    11761 gctgttacaa aggaaatggt tgaaagtatg tctgagaagc caataatatt ggcaatggca
    11821 aatcctactc cagagataat gccagaagaa gcaaaattag gtggagcatt tataatggga
    11881 acaggtcgtt cagacttccc taatcaagtc aataatgtac tggcttttcc tggaatattt
    11941 agaggtgcac ttgatgttaa ggctaaagag ataaatgaag aaatgaagat agctgctgca
    12001 tatgcaattg ctaatacaat aagtgatgaa gaaatatgcc cagagtatat attaccagat
    12061 gtatttaata agaatgtagt aaaaaatgtt gctaaggcag ttaaagaagc agcgataaaa
    12121 actaaagtaa atagaatata aatttttata tgttcatata tccttatatt atcgggtata
    12181 tgggcatttt tattataggt ttatactcat atatccttac ttttatatac atatctttat
    12241 gattaaaggt gttagaaaat gtagtaaatt ttatactatc agactctatc tttattactt
    12301 tagtagatac atggttgtaa aggtttatag aaaaaaatat aggaaggcag atttttattg
    12361 ttgcgtatat atgagaatga tataatatga atattataaa ttaataaatt taaatttatg
    12421 gaggtacaag agatgatgga atataaagtt aatgaccaag aacttaatgc ttcaatgttt
    12481 atcccattcg tcaacaggat atggccagga gattatgata tggataaaac acagactgca
    12541 ttatcaaaaa ctttgaatat aactgcttat gatgataaag tgcttgtagg atgtctgcga
    12601 gttctttcag atggttatta ttttggaaca attacagaat tgcttgttct tccagagtat
    12661 cagaaacaag gcattggtag taagcttttc cagcttgcta aagagaacac cccaactatg
    12721 ctatattttg gtgcacagcc aggagtagaa gcgttctatg aaaaaaatgg gtgccaaaga
    12781 agtctgcaat cctacataat aaaaaagaaa gatagttatt aaagttccag ctttcaataa
    12841 tcttaaaagt acaatatttt agtggaatca tttcattttt tattactaat atgacataaa
    12901 catgtcatat tagtattgat atacttttaa tatggttaag agccaaagaa aaatataagg
    12961 agtgatttaa aatggaagaa actaaatttt gccaatgctg tgcaatgcca atgggacaaa
    13021 ctgatgaatt atatgggaca aataaagatg gaagtaaaag tactgattat tgtagttatt
    13081 gttttaaaga tggtgagttt acagctgata taagtatgga agagatgata gaagtttgta
    13141 tccctcatat gcttcaaagt aataaggata tgactgaaga tgaagcaaga acaatgatga
    13201 acaatttctt tccaacatta aaacgctgga aataatttta tgcaaaatta gttatatgca
    13261 aaacatgaaa tatggtgttg agaataaggg gtggtgtgct ttatagcata ccacctgttt
    13321 tgttacttgg agttcagtta ttttcctaaa tattttaaat atactatttt agataagttc
    13381 cctcttcatc ttgataaatt aatccttttt tcataagcac tccaagagct cgtttaaaat
    13441 ttttcttact tgaattaaat aatatagaaa tatctttagg gtcagattta tcattaaatc
    13501 tcatatatcc atcagaacct tctaaataac ttaaaatctt attttctaaa gtatcaagtt
    13561 catcctttct atttcctcta ggagaaagac caagttttcc atcttcatat atttttatga
    13621 catgtaaatt ttcaagaaca tcaccagttt ttagttcagt aaagtactca ttatgaagta
    13681 ttacaccagc atatttattg tctacacata tcattgcaga attattagtt tggaatccat
    13741 atacaactcc agttacaata tctcctacat tgtaagtatg gtctgttaat aagtatgaat
    13801 ctatgtctgt agtagcagca attcttttgc ttttgtctaa atatatataa aataaatatt
    13861 tttcgtctct aaatagtgga taagtcttag ctttaaaagg aactaatatg tctttaggaa
    13921 gtcccatatc tataaaagta ccaatgtctg tattatcaac tacttttaaa tgtgctacat
    13981 ccccaacctt agctaaaggc ggtattaaag ttgcagcagt tctgtcatca gaatctttaa
    14041 atatgaaagc atttacttca tcacctatgt ttatttcatt ttttccgatt aatctattat
    14101 gaagaagtat atcgtctttt gtgttattag tttgtccatc caaaaaatat ccaaattcag
    14161 tttttctttt tactgtaagt ttattaaaat cacctatgtt tatcaaatta aaatcatcct
    14221 ctcattttat atttataatt tagccataat atacttatgt agtagtttgt cacagtatcc
    14281 atattagtat tagtgaaatt tacaataaat aatatagtta tttatgtatt tttcaattct
    14341 ctagcttctt atatagtata aactccaatt tcttttttgt ctttaggttt tattaaaatt
    14401 tttacaaaat aagttaaaaa gtattgaaat aaaatttctt ttaaagtata attggtatat
    14461 accaaaattg gtatatacca tatcgaaaag tggtgactat atgaaaatag taaataaatc
    14521 tagtaatata ccattgcata ctcaattaag ttcaataata agagagatga tagaaactgg
    14581 tgagcttaaa gagggcgatg caataatgcc agaaagagaa ctttgcaaca tacaaaatgt
    14641 aagtcgtatg acagtaaata aaaccattgt tggattagtt acagaaggac ttctttatag
    14701 ggtacaaggt aaagggacat tcgttgcaaa gcaaaaaaag aagtatcagt tttcaaatgt
    14761 aaaaggtttt actgatgtta tgaaagaaaa gggagtaaac ataaaaacgg atatattatc
    14821 ctttgagatg gaactaccag atgatttagt taaaagaaag cttggaataa gtgataatac
    14881 tacaaatata tataagattg tcagacttag atatactgat ggagagccat ttggattaga
    14941 aatagtatat ctatcagaag aaatgtgtaa gggtctaaca aaagggatat tggataattc
    15001 ttcattatat agggttttaa atgaaaaata tggctataag atacaaaaag ctgaacaggt
    15061 aatggagcca gtaatacttt cagatgaaga aagtaagctt cttgaaacag atgaaggtgc
    15121 tttagctctt aaacttcata gaaattccta taatagagaa ggtagcccta tagaatatac
    15181 catatcaata tttagaacag ataaatatca atatgaaata gtattgagtg agtaggtgaa
    15241 taatatgaaa tgtttaatta atggaaagat aatattaaaa aatcaaatct tagaaaataa
    15301 agtattagta tttgatgaaa aaataattga tatagctgat agtgtaccaa aagattgtga
    15361 agttatagat gctgatggaa aatatatatc tccagggctt attgatattc atatacatgg
    15421 aaacatggga aaagatacaa tggattcgac tgatgaatct attgaaacaa tttcaaagtc
    15481 aattatgaga catggagtaa catcttttct tccaactaca atgactatgg ataaagaaca
    15541 tgtttatgat gcacttgaag ttattaaaaa agcccaaaat agaaagcttg aaggggcaca
    15601 agtattagga gcacatttag aaggaccttt tataaatgag aattataagg gagcacaaaa
    15661 tgaaaaattt ataataaatt caaaatacga atttataaaa gaatataaag atgttataaa
    15721 agttataact tatgctccag aaaaagatat tgattttgat tttactagag aaataaaaag
    15781 atgtacagat atagttttat ctattggtca tagtaatgca aattatgacc aagctaaaga
    15841 agctataaat ttaggagtaa ctaatgtaac tcacatgttc aatgcaatga ctggtttaaa
    15901 ccatagagac ccaggcgttg ttggtgcagc acttacaact aatgtgtaca gtgagttaat
    15961 agcagataca atccatataa ataaagattt atttcaattt atactaaata ataaaggaaa
    16021 agaaagactg attttaataa cagattctat agaagctggt ggtcttgaag atggcaatta
    16081 ttctcttgga ggtcagaaag tcatagttaa gggtaatgaa gctagacttg aaaatggagc
    16141 attagctgga agtgtgttgt ctttaaataa aatggtattt aacttcttag ataatacaaa
    16201 ccttaaagtg aatgaagcaa ttaatttagc ttctttaaat ccagcaacat ctttgggaat
    16261 aaatgacaaa aaaggaagct tagaaatagg taaggatgca gatatagctg tatttgatga
    16321 gaatttagat tgtaaaatga cactttgctt gggggacgta gtatataaaa atatatagta
    16381 tacaaaacaa accttaaaga cagtaaaaac aatataaaaa ataataaatt aaacttacat
    16441 tagtaaaagt agtagttaaa atttaggagg aataagatga gagtattagt gtgtaaagat
    16501 tatgatggaa tgagtaaaaa agccgctgaa atgatagcag ctcaaatagt tttaaaacca
    16561 aattcaatac tgggactagc tacaggaagt acaccagtag gtatgtatag agatttagta
    16621 aaaaaataca atgataatat agtagatttt tcagatgtga tgagctttaa tttagatgaa
    16681 tattataagt taccaatatc taatgaccaa agctatgatt attttatgaa agaaaatcta
    16741 tttaatcatg taaacataaa gccagaaaat actcatctac caaatggaat ggctgatgat
    16801 attgaaaaag agtgtatgaa ctatgaagct tctatagatg cagctggtgg tatagatgta
    16861 caagtacttg gaataggtcg taatgctcat ataggtttta atgaacctga tactaaattt
    16921 gcaaagagaa ctcatgtagt tgaacttaca gagtctacaa tagaagctaa tgcaagattc
    16981 tttaaatcaa gagaagatgt tcctaaaaaa gctgtaagta tgggaatagg ttcaatattg
    17041 aagtctaaga aaatattgct tttagcttca ggagaagaaa aagctgatgc agtatataat
    17101 actgtttatg gagatataac tccagaagtt cctggttcta tacttcaact tcataaagac
    17161 actatagtta tagtagatga agcagcagca agtaaattga atccaaaaga ttataaatta
    17221 gtataagaat agaatgtagt ttaagtaaaa aatagctatc attgagtaat caaatttatt
    17281 taatgatagc tatttttatt taaatttttt acttcttttt atttaaatta gttattattg
    17341 tttaaattac ttgcttatta ctttttacga aaactcgtta tcaagaagta tccaaataag
    17401 atgttaaaaa ttattatgtt tagtgggatt ctatcaagca taataaaatt acctataatt
    17461 gggatattac caactggaaa cataaagaag aatacaggca tcagtgatag taaaaaagat
    17521 ggaaaacaaa gaagaagtaa tcttggaata tcaatatacc aactaccatc ctttttgtat
    17581 tctctaatca ataattcagt tcctagtaat aaaccaatac caccagagga aattaaatta
    17641 ataaaaatgt atcttttaaa gtcttgcata taaccagtgt aaaattgagt atagaaatca
    17701 taatttaatt taacagctaa aaaatacata agcaatagaa tgattaaaaa taaaagatat
    17761 ctaagagctt ttttcatttt aaattctccc ttcagaaata ctttattcag ttttattttg
    17821 ttggaatctg attttatcat ttagtttaag aaatccataa tattagtgaa gaatgaaata
    17881 agtattatat atgaataaat atttttagaa ttaaggtgaa ttgtagtgct taatataact
    17941 ataatattaa ttgtttgaat attcaataaa aagtttgaaa aatatcaatt ttgatataaa
    18001 ctgaataaat acagttgaat attaaattat tattttatca aaaatatgca aagtactaca
    18061 ccttcaaata tcacctaaag taattaaaag gcaattaagg tgaagtagtt caagtatttc
    18121 taaaataagt ttaataaatt ctataataat ttattttttg ccttaaaatt gccttaaaat
    18181 ccaaacaatt ttaaaactaa tgtactataa aaagctggta taatttaaat atagtaaaaa
    18241 ataagattta tcttatctat tgggatttaa ttatttaatc aatatattta taccatttaa
    18301 tttaaataaa aagtctatta aggagtgagc ttatgagtaa gttaatttat atagcagatg
    18361 atgaagataa tataagaaat ttggtaaaga cattcttaaa aaatgaaggt catgatgtta
    18421 tggattttaa aacgggtgat gaacttttag aacaatttaa tataaaggag tgtgacttag
    18481 taatactaga tataatgatg cctggctcaa gtggttttga agtatgtaca aaacttcgtg
    18541 agaaaagtac agtcccaata atcatgctta ctgcaagaga tacagatata gattatatta
    18601 cagggataac cttaggtagt gatgattatt ttacaaaacc atttagccca atgtctttgg
    18661 ttatgagagt aaaatctata tttagaagga tagagtttga aaagaaacaa aattatgata
    18721 aatatagtaa ctcgatagat atggaattaa aatttggtga tgtaataata aataaaaaga
    18781 ataaaatcgt tacaagtaaa aatgtaaata tagaccttac accaaatgaa tataacctat
    18841 tgacttattt gtttgaaaat atagatagag cagtttccag agatgaatta ttaaacaaaa
    18901 tatggggata cgatatagaa gttgagacaa gggctgctga tgatacagtg aagagattac
    18961 gtaaaaaaat tttaaataca aatattttaa tagaaactgt atgggggttt ggatttaggt
    19021 tgaaggagaa aagttaagat gaagaatgga aatgacaaga atagaattgg aaagattaaa
    19081 tccaaattta aattaaagtt ctcaaagaaa aatataagca taaaaactag gattttgttg
    19141 agtatacttt gtttgataat tatagtattt atgataatat tagtatcttt taatgtattt
    19201 cttgatacat atataaaaac aactgcgaat gaagaattga caaagtctac agaaatagta
    19261 gaacatatgg atagtaattt tagacctatt aagccaccac aagatgatgg aaagcttcct
    19321 cccaaagtat tatctaattt tatgagaaat gtacaagata aagttaggat ggcagaaaca
    19381 caatcagatg ctgatgctat ggtagttgat tctaagtata acctgatatt tccaacaaga
    19441 gaggatgatt tcttaaaaaa tgttgatgag atggagctga ttagggagtg tattcaaaat
    19501 gaaaaattag atttaaattc agatgaaaat acacggatat ctaccagaaa taaggattat
    19561 tatatttcaa ctgtaaaaat tactagtata tatggtgaac aagacaagta tcttatactt
    19621 tttatagaca tatcaaaaac tctaaatcta gcacaaaaga taaatattgt attaatatct
    19681 gtaatgtgtt ttgctggaat attagcaata tttacagctg tgattttatc tgagaaaatt
    19741 gctaaaccga taaaagagtt gtgtgagttt gtaaaaaaaa tgggtcaagg agatttcaaa
    19801 agaacctact ttgacttttc agataaagaa ttagtagagc tctcaactgt tatgaataag
    19861 agtgctgagt atctggataa gtatgataat gaacaaaaaa tattttttca aaatgcatct
    19921 catgaattaa ggacaccact tatgtctatt aaaggttatg cagaagctat aaaatataat
    19981 gttatagata gtaaacatgc aagtgatata attcttgaag aaagtgatag gttaagtgat
    20041 atggttgaag atttattata catttctaaa atagataata taactaaaga ttttgaactt
    20101 gtagaatgtg atttaagaga agtactttca aattgtggag ctaggcaaaa tgtaagagct
    20161 ataaataagg ggataaaatt tatttatgaa tttgatgaag aaatggtttt atttgaatgt
    20221 gatgaaaaaa acatttccaa agcatttatg aatcttatag aaaatgcttt gagatacgct
    20281 aagagtgaaa taaaaatagt gtgtaagtat aatcaaaaaa atatagttgt gataatagaa
    20341 gatgatggaa ttggaatcaa gaaagaagat ttacctcatg tttttgaaag attctataag
    20401 ggagtagggg gaaatcatgg aattggatta tcaatagtta aatctattgt aaataagcat
    20461 ggtgggcgta tatacgtaga aaatggcaaa aaaggagcta aatttactat attatttaaa
    20521 ttgtaaaaaa attagagaaa atatagagat gtttgaagtt gttttttata tatatctgtt
    20581 gtatactgtt gaaaaaagaa caatattaag ctgacatata ttacgatagt tgacatttaa
    20641 agtaaatgct taaatataga tacgaaagga aaagtaaaat ctgaagtgta tttaggttta
    20701 agtaagcttc ttattttata aaaaatatgt atgaaagaac agctgatttt taatattaca
    20761 aatttagtaa cggttgtatt tgaagctttt gtcatccata tgtttttatc agacttttta
    20821 ggtcagaaag aagggtatat aaaagttgta agatatgcta aactgggttt tataatatgt
    20881 ttaggattct gtaatttaat aactttaaac cctaaaatca caatgccttt aattttcatc
    20941 cttatttttt caacatcatt tttatataaa ggaaatttaa agacacgatt gtttactact
    21001 gttttattaa gtatattctt tatactgtca gaaattgtag ttacaagtat ttttgtttta
    21061 tttgtaaaag aaggctttga aataatgctt gaaaataata gtataagagt attggcgaca
    21121 attttatcta aaattgtctt tttgttgact tgtaaaatta tttgtctatt taaaaaggat
    21181 gtacatttag atatgcccat aaagtattgg ctccctttat ttttaatacc tatatttagt
    21241 ttatttctgt ctgtttctat ctttgatgta agtaaatttt ttagtcttga aagtttaaaa
    21301 tttctaagct taatatctag tgttggtatt ttatatatta attttattgt cttttattta
    21361 tttaaattta ttatagataa aactaaacta tctatgaaat atgaactact tgaaaaagaa
    21421 ataattcata aggaagaatt aagacttagt aatgagtgtt ataaaattat tgttgaacag
    21481 actgattctg tcgttttcga atggaatatc aaagaaaata aatcatttgt atcgcaggct
    21541 tggactgaaa aatttggata taacaatgca tgtaagaata tttttaaaga aattaaagat
    21601 aaagacttag ttcattctga agataaagct atatttgaag gttttcttga aagtattaaa
    21661 aaaaagaata tgcacaatca agcagtatat cgtttaaaaa aatctaatgg tgaatatatt
    21721 tggtgtagaa catcaattac aagcatttat aatgatgaaa atgaactttt aagagttgtc
    21781 ggagtaattg tagatgtaga tagtgatata aaaaaatatg aagagttaag aactagagca
    21841 gaaagtgact cattgaccaa tatatacaat aaaggtacat ttgaaaaatt agtggaagaa
    21901 actatagtta tgaatacagg tgataaaaaa gatgcattat tcattattga tttggatgat
    21961 tttaaagaaa taaatgataa ttttggtcat ccatttggtg attttgtact aaaaacattt
    22021 gctgataaga tacaaactag ttttggtagt aaagacttag tcggaagaat tggtggagat
    22081 gaatttgttg tatatatgca agattatgtt acagaagtaa atttgcataa aaaagctaaa
    22141 gaattaaata gagtactttc ggataattac actgatttga gttttagttt tgatgcttct
    22201 gtcagtatag gtattgcaag gtatcctcaa gatggaactt cattttttga attgtttaaa
    22261 aatgcagata gagcacttta tagcataaaa gcatcaggta aaaattcata ttgtttattt
    22321 gaagaagaac tatatgtaca gtgaatttga atttagattt tatgtgagag taagatttat
    22381 atatacttgt ggctgtctga tttataaaat atgttacttt gtatattttt atatgtttca
    22441 gtaaggttaa ttaacatgag caaaggtgta agtaaattta tattagttta agtttactta
    22501 cacctttata aaaatacaaa taatagattc atttacattc ttaaatgatt aaagctcttt
    22561 accttctaaa catgcataac atatcgttat aattccagta aataagacta aaatgcccat
    22621 tactaagatt acaatttcat catctattac tccaaatgtt tttaaagtaa cttatttcgc
    22681 tttgtatcat aataatttgt ctctttttac attttaactt ctgctgagat ttgagttaga
    22741 tattcattag aatctcgcac acttatatca tatagaagat attcttcata aacaaaatcc
    22801 ccaatacgta aattattctg attaaaaaaa tttaataact tttcataagc cttgtaaata
    22861 gtttcataac tccctttatg ataagcagtt acataaagtc cctttggttt gattgataca
    22921 ggatatttct tgtactcttt attaactttt gtaaataaat atgaatatga ttcaaagtct
    22981 ttattaatta tatcttcacc tttaatgatt gagccaatcg taccataatc actcaattca
    23041 tagttgtcca taaagttaat acattcatat aaaaaatttt cttcctcatc tcctaaaaac
    23101 tgttctttat atgtaacagg tgttttgacc aagtactctt cttcatgttc ttttaaagta
    23161 atagtattcg catctatatt acatgcactt ttagtaaatg aaatagtaga ttccattaga
    23221 gcttgaatat tatttagttt ttcaatttca tttttaatat caatggtttt cttttctaaa
    23281 agctcaatta gtaaattagg tgttcttttg tctatataag ctttaatttc ttttaaaggc
    23341 atttttactt ccctaagtga agaaattata ccaaaaatgc taagttgatg gtatgagtag
    23401 tatctatatc cattttcttt ctttaattct ggtgagaaaa gacctatatc atcataatgg
    23461 aaaagtgttt ttttattgat tccacaaatc tttgcaaatt ctccagttgt aaaataattt
    23521 tttgaaactt gactcataat tataattcct ccttgactat cctgttacag tatagtttat
    23581 catagtattt tgtaaaggag tgtgattata tgaaaaaatt aattcatttt ttaaaaccat
    23641 atagagtttt aattgttgta gttttgatat ttacgttttt acaaacactt ggaactttgt
    23701 atataccaac acttacagca aatatagtaa ataatggtgt agtaaaggga gatatagatt
    23761 atattgtaaa aacaggttta atgatgatga tagtagctgg tataacagct ttatcagctg
    23821 tgttagtttg taaagtatca gcaaatcttt catctggatt ttgtagagat attagagaag
    23881 cagtatttat aaaatcacaa gatttatcaa taaatgattt taataatata ggtacagcat
    23941 caatgattac taggagtact agtgatatta ctttaatagg tcagtctgtg tttatgttta
    24001 ttcaattagt attaccagca ccaattataa ctgtttctgg tctattctta gcatattcta
    24061 tagataaagc aatgacaatt attattgttg tagtaatgtt tttattcatg ctttcagcat
    24121 ttttagttgg taaaaagctt ataaagttgt ttaaaatgat gcaaataaag atggataata
    24181 tgaatagggt gttacgtgag gtagtaactg gagtaagagt tataagagct tttaatagga
    24241 gtcgttttga aaaaaagaga tttgatagaa ctgcaataga ttattctgaa acagcaattt
    24301 caataaataa aatatttgca gtacttatgc ctattgtaat gttaataatg aatttaggta
    24361 tagtaagtat tatttggttt ggtgggatga gagtcagtaa tggaaatatg gaaataggtc
    24421 atataatggc acttgttgaa tattgtatct taattttatt ctatttaatc atgggagtaa
    24481 tggtatttat gtacatacct agagcaggtg catgtgcaga tagagtaaat cagatattag
    24541 atatagaacc tgaaattgta gatggaaatg gtcataaaga tactgtctca gagagaggac
    24601 atttagtatt taaaaatgta accttttcat atgcacaatc agaagaacct gtgttaaata
    24661 atataacatt tgaagcaaaa tctggagaag taactgcaat tataggaagc actggctcag
    24721 gcaaatctac tattgcaaat ataataccac gtttttttga aattcaatct ggagaaatat
    24781 ctataaatgg tcaggatatt aagaagattc ctcaaaaaga acttagagat aagattggat
    24841 ttgtaccaca aaaagctttt ttatttagtg gaacaataga agaaaatata aggtatggaa
    24901 aagaagatgc aagtattgaa gaagtaaagc atgctgcaag tatagctcaa gctgatgaat
    24961 ttatttatga tatggaagac aagtatgact catttgtagc acaaggtgga aataatttgt
    25021 caggtggtca aaaacagaga atatccattg caagagcgtt agttagaaag cctgaagtat
    25081 atgtctttga tgatagtttt tctgcattag attttaaaac agataaaaga cttagaaaag
    25141 cgttgaaaaa tgaaatcaaa gattcatcag ctataattat agcacaacgt ataagtacaa
    25201 tcatggatgc taatcagatt atagttttaa atgatggaaa aattgtaggt attggaaaac
    25261 ataaagattt acttgaaaat tgtgaagttt ataagcaaat tgcggattca caacttagta
    25321 aagaagaact tgcataaaat gaagaattaa tctgatattt ggaggtgtat gatatgagtg
    25381 aaaaaagaat agatgaacaa gatatagaag tacttagttt tgaagatggc atgtcagcag
    25441 aaaaagctaa ggatgcaaaa aaaactacta agagattatt aaaatatatg gcaaaacaaa
    25501 agtttaaaat attaattatt tttatttcag tattgataag ttcagcgctt acagttttag
    25561 cacctatggt tatgggaaaa gctattgacc aactatttaa tggaataaaa actgcagtcc
    25621 aaacaggtac aaaattcagt gtgaatttta gtactatggg agggatagta tcaatacttc
    25681 tagggttgta cttaattagt gcagtattta tatatattca acagtatatt atgtcaggag
    25741 ttgcacaaaa tctagttctt agcatgagaa aagatttaag tgataaactc aataaacttc
    25801 ctcttaagta ctatgattct cataaaaagg gggaaacact tagtatagta acaaatgatt
    25861 tagaaaaagt agcagatagt ttacaagaag gattaatgca acttattaca gcagtagtta
    25921 cagtagttgg ttctattgta atgatgataa gtataagtgt accacttaca atagtatcag
    25981 ctataacatt acttgtttca ttgggtatta ctgttgtaat tgcaagaaaa tcacaagaaa
    26041 gattctctga aaatcaaaag gcactaggag agttaaatag caatatagaa gagatattta
    26101 ctggtcaaat agtggttaaa gcatttagta aagaaaagga tactataaga aactttaaaa
    26161 tattaaatca aaatctttat aatgcaagta gaaaagcaca gttttcgtca tatgcaatat
    26221 ctccaattat tagatttata aacctaattg gctatgttat tatagcagtt gtaggtggga
    26281 tatttgcatc aactggagca atgactcttg gtagtataca agcgtttatt caatatgtaa
    26341 atcaagcatc agagcctact acagaaatat cttatattgt aaatatgctt caagcagcaa
    26401 tagcatctgc agagagagtt tttacagtta tggacgaggt ggaagagata aaggatgaag
    26461 aatcttcaaa ggttattagc atgcctaaag gtaaagtaca atttgagcat gttaaatttg
    26521 gatatagtga tgattttatt cttatgaaag atattaatat caatctaaat gcaggagata
    26581 agattgcaat tgttggacct acaggagctg gaaagacaac tcttgtaaat ttacttatga
    26641 gattttatga gatacaaggt ggaagaatta ctattgatgg tgttaatata aaagatttaa
    26701 agcgtggaga acttagaact atgtttggta tggttcttca agatacatgg ctgtttaatg
    26761 gaagtataaa agaaaatatt gcatatagta agtcagatgc cacaatggat gaaattgtaa
    26821 gagcagcaaa atcagcaaga gtagaccatt ttataaggac tttaccacaa gggtatgaca
    26881 ctatattgac tgaggatgct tctaatctat ctcaaggtca aaagcaactt ctaacaattg
    26941 ccagggcaat actttcagac ccatcagtat tgattcttga tgaagcaaca tctagtgtag
    27001 atactagaac agaggtagaa attcaaaagg caatgaataa cttgatgaag ggaagaacta
    27061 gttttgttat tgcacataga ttatcaacta ttcgagatgc tgatttaata ttagtaatga
    27121 aagaaggaac tattattgaa caaggaagcc ataaggaact tattgaaaag aaaggattct
    27181 atgaagaact ttataacagt caatttacaa gtgaatatga tgaagatgtt gtatgattat
    27241 caagttttag gcaactaaat gattgataaa tattaagtta aatatagtaa catgtaaggt
    27301 tatatggaat aagagtattt ctctatttca tataaccttt tttatttatc aaaataagat
    27361 aaaatttcct ttctaaatta gattgaagaa tgtatttatc aatataaaag taaaataatc
    27421 attattatta gtgaagtaaa tattgtttgc cacatatatg ccataaagat gcacttattt
    27481 tacggagatt taacaaagta gtgtaaagta tactctaaat ataaaataaa tcaaatagag
    27541 ttaaataaat tgagaggtga tataaatagt gaataaaaaa ttgaactata gatttgaaat
    27601 gaagcacaaa ataactgaag cagatgtgtt agctttaaaa tcaagactct atccaataat
    27661 gaagaaagat gaaaatgcat ctaaagatgg aaaatatctt attaggagtt tatattttga
    27721 tactcctgaa gataaagcac ttttggataa attaaatggc gttgcaataa gagaaaagtt
    27781 taggataaga ttttataata atgactgctc ttatataagg ttagagaaaa aaatcaaaca
    27841 ttacaacatg acatcaaagc tatcaactaa tttaaccaaa aaagaagtaa taaatatact
    27901 aaataatgat attgaatttc taaaagagtc gacaaattgt ttattaagag aattttattt
    27961 gaaattaaaa tgtgaaagat tagaggcaaa aagcatagtt gattacaata gagaagcttt
    28021 tatttatcca gttggaaatg taagagttac aatcgatagt gatattaaaa cttctgtaaa
    28081 ttcggtagat ttatttaata aagatttgcc aactatttcg gtaattgatg agaatatgac
    28141 tgtattggag gttaaatatg atgaatttat accagatttt ataaaggatt taattcaaat
    28201 taataagact acctctacag cagtttcaaa gtatgcttca agtagattat atatttaaga
    28261 ataaaggcta tgatttatat aaagatatac ataaataagg ttaaaaaaca aataagttaa
    28321 aaataaataa aataaaaaat aaataagtta aaaataggaa ggatgatttt aattatgaca
    28381 tttaatgata tttttaaatc aagttttata gaaaacgtat caggtttttc atttgtggac
    28441 agtgctttag cactaggttc agctttttta gtaggtttgt ttatatatat ggtctataaa
    28501 aagacttata tgggaattat gtattctcga ccattcaatg tgtcgcttgt agcacttaca
    28561 atgcttacaa cttttgtaat attggcggtt acttcaaatg tagttttatc cttaggtatg
    28621 gttggtgctt tatctatagt aagatttaga acagcaatta aagacccaat ggatttagta
    28681 tttctatttt ggtcattagg ttcaggtata gttttaggag caggtttgat tcccttagct
    28741 gtcatgggtt caataattat gggattgatt ctaatattct tttcaaataa aacaatatct
    28801 gaaactccat atatattgat ggtaaattgt aataatgaag attcagaaga tatagcaact
    28861 gataaaatta aaaaagtatt tactaaatat caaataaaat caaaaagtgt tacaccagaa
    28921 aaaggaatag aattagtgtt tgaagtaaga atgaaagatg gagaaacaag tcttataaat
    28981 gacttgagtc aagtagatgg agttactaat gcagttcttg taagttataa tggtgactat
    29041 gtagcataga gaggagtaat cttttatgaa agataaaaaa tttacccttc ttatctcgat
    29101 tatgattata tttttatgtg ctgtagttgg agtttatagt acatctagca acaaaagtgc
    29161 tgatttatat agtgatgtat atattgaaaa atattttaac agagacaagg ttatggaagt
    29221 taatatagag atagatgaaa gtgacttgaa ggatatgaat gaaaatgcta taaaagaaga
    29281 atttaaggtt gcaaaagtaa ctgtagatgg agatacatat ggaaacgtag gtataagaac
    29341 taaaggaaat tcaagtctta tatctgtagc aaatagtgat agtgatagat acagctataa
    29401 gattaatttt gataagtata atactagtca aagtatggaa gggcttactc aattaaatct
    29461 taataactgt tactctgacc catcttatat gagagagttt ttaacatata gtatttgcga
    29521 ggaaatggga ttagcgactc cagaatttgc atatgctaaa gtctctataa atggcgaata
    29581 tcatggtttg tatttggcag tagaaggatt aaaagagtct tatcttgaaa ataattttgg
    29641 taatgtaact ggagacttat ataagtcaga tgaaggaagc tcgttgcaat ataaaggaga
    29701 tgacccagaa agttactcaa acttaatcgt tgaaagtgat aaaaagacag ctgattggtc
    29761 taaaatcaca aaactattaa aatctttgga tacaggtgaa gatattgaaa aatatcttga
    29821 tgtagattct gtccttaaaa atatagcaat aaatacagct ttattaaacc ttgatagcta
    29881 tcaagggagt tttgcccata actattattt atatgagcaa gatggagtat tttctatgtt
    29941 accatgggat tttaatatgt catttggtgg atttagtggt tttggtggag gtagtcaatc
    30001 tatagcaatt gatgaaccta cgacaggtaa tttagaagac agacctctca tatcctcgtt
    30061 attaaaaaat gagacataca aaacaaaata ccataaatat ctggaagaga tagtaacaaa
    30121 atacctagat tcagactatt tagagaatat gacaacaaaa ttgcatgaca tgatagcatc
    30181 atatgtaaaa gaagacccaa cagcatttta tacttatgaa gaatttgaaa aaaatataac
    30241 atcttcaatt gaagattcta gtgataataa gggatttggt aataaagggt ttgacaacaa
    30301 taactctaat aacagtgatt ctaataataa ttctaatagt gaaaataagc gctctggaaa
    30361 tcaaagtgat gaaaaagaag ttaatgctga attaacatca agcgtagtca aagctaatac
    30421 agataatgaa actaaaaata aaactacaaa tgatagtgaa agtaagaata atacagataa
    30481 agataaaagt ggaaatgata ataatcaaaa gctagaaggt cctatgggta aaggaggtaa
    30541 gtcaatacca ggggttttgg aagttgcaga agatatgagt aaaactataa aatctcaatt
    30601 aagtggagaa acttcttcga caaagcaaaa ctctggtgat gaaagttcaa gtggaattaa
    30661 aggtagtgaa aagtttgatg aggatatgag tggtatgcca gaaccacctg agggaatgga
    30721 tggtaaaatg ccaccaggaa tgggtaatat ggataaggga gatatgaatg gtaaaaatgg
    30781 caatatgaat atggatagaa atcaagataa tccaagagaa gctggaggtt ttggcaatag
    30841 aggaggaggc tctgtgagta aaacaacaac atacttcaaa ttaattttag gtggagcttc
    30901 aatgataata atgtcgatta tgttagttgg tgtatcaagg gtaaagagaa gaagatttat
    30961 aaagtcaaaa taagattaaa attgaatata aataatttta atactgttaa gtctaaatat
    31021 ttacttagca gtattttttt agaaaataat gtatttggtt aataatataa ggtaataaat
    31081 tgataaaaat taaatacagc atattaataa tacataataa agtaataaaa aaactgttta
    31141 agtataataa cttatattta gacagttttt ttcatttata aataatataa atgaaattga
    31201 aaacatttga aggatagaaa ttggttggat aaatgtataa attacttcac caaaaaataa
    31261 tgacaaaaat tgtaactaag ttgtaataaa atggtagtta tttagcataa aataatgtat
    31321 catagaagta tattataaaa ttaataaaat aagatttttg taagaaaact gctggctttt
    31381 gatatttaga gtgagtagtt aaattatgtt taggaggggt agaatttgtt gcaaaaagta
    31441 ttatggaaat ttttaaagct agtagtcggt ttatttatat gttcagttgg tatagtattg
    31501 acgataaatt gtaaccttgg attatctccc tgggatgtat ttcatcaagg actttcaaat
    31561 catataggaa taactatagg aactgcttct ataattgtag gctctatagt agttattgct
    31621 gatgtcgttc ttggagaaaa tgtaggatgg ggaactgttt ttaacatgct actaattgga
    31681 ttctttatgg atttactttt atatagtaat ttaattccag aggctgatag tttatttgta
    31741 ggaataatta tgttgatatt aggattggtt cttttgtctg ttggaatggt attttatatg
    31801 ggaagtggtt taggaagtgg acctagagat ggtttgatgg ttgcaattca aaagaaaaca
    31861 ggaaaatcac ttaaattaat aagaggtact atagaagttg gagcattaat agtaggattt
    31921 ttattaggtg gaaaagttgg tataggaact ataataagtg catttggatt ggggtatttc
    31981 acacaaatgg tatttggctt atttaaatta gattgtagta agattaaaca tagatttata
    32041 gtagatgata taaaatttat caaagtgtat atgagtggtg agaaaaaagc tgctgttcaa
    32101 aatatagtta agtaatttaa gaataaattc aacgaaatgt taagtatttt aaattaacat
    32161 tttgtttaga tagataaatt gaatattaaa agaatattaa aatatgagga ttgctagaac
    32221 actataaaat atagatttct agcaattttt tatttgttca atattttttt agtactagaa
    32281 gtcttattct ctatttaatg aatgaattaa tttataatta gagatactaa actttataga
    32341 tattaatata aacaccttta aactgtgtat tttccaaagc ctttaaaatg cttgtattta
    32401 ttctaaataa aaaaataaaa aaatgtcaaa aaaactcttg tattatatcc aaattttata
    32461 tataattacc tatgttgttt agaaatttta aactcaatgt ttagtaaaca aaatgtttag
    32521 taaaataaaa cagaaactag gaggtgcaac atggatatag gtgaaaagat aaaaagatta
    32581 agaacagaaa aacaactgac ccaggaagag ttagctaata gatgtgaatt gtcaaaggga
    32641 tttatttctc aattagaaaa taacttaaca tcaccatcca tagctaccct tatagatata
    32701 cttgaaatac taggtacaaa tttaagggaa ttttttaatg aaatagatga tgaaagaatc
    32761 agttttacaa aagaagatat gtttgaaaca gaagatgaag atttaaaata taaattaaag
    32821 tggttaattc caaattcaca aaaaaatgaa atggagccaa taataataac attgtatcca
    32881 ggaggacagt ataaagaaga aaagccacat gaaggtgaag aatttggata tgtattagca
    32941 ggttcaatat atgtccatat aggcgaaaag aaaaataaag taaaaaaagg agagagtttt
    33001 tactttagac cgaaagcaaa tcactatata tcaaacgagg gcaaaactac agcaaaagtg
    33061 atttgggtaa gtacgccacc atcattttag aatagaggtg tttaataatt ggtagaaaat
    33121 ataatagaat taagggatat atctaaacat tatgaagaac ttactgtttt agataatttc
    33181 aatttagata taaagaaaaa tgagtttcta acattacttg gaccaagtgg atgtggaaaa
    33241 actacaacat taaaaataat agcaggattt gagtatgctg atgatggtaa agttttattt
    33301 gaaggtaagg agataaataa tttgccacca tatgaaagac aagtaaacac agtatttcaa
    33361 aaatatgctt tatttccaca catggatgtt tatgaaaatg tagcttttgg attaaaaatt
    33421 aaaaagactc caaaagatgt aatagatgct aaagtaaaag aggttttgaa acttgttgca
    33481 ctagaaggtt ttgaaagacg acaagttgaa tcattgagtg gaggacaaca acaaagaatt
    33541 gcaatagcaa gagctctagt taatgaacca aaggtattat tactagatga accacttgga
    33601 gcacttgatt taaagttaag acaagagatg caaatagaat taaagagaat ccaaaaaaaa
    33661 ttaggaataa catttgtttt tgtaactcat gaccaagaag aggctcttac tatgtcagat
    33721 actattgttg taatgtataa gggcaaaatt caacaaatgg gaacaccaca agatatatac
    33781 aatgaaccta aaaattcatt tgtagctaag tttataggtg aaagtaacat atttgatgga
    33841 attatgatag aagattataa agttaatttc tgtaatagag attttgagtg tgttgataaa
    33901 ggattcgaaa aaaacgaaaa tatagaagta gtaataagac cagaagatat aaaaatggta
    33961 aagccagaag aaggaatgtt aaaggggaaa gttacatcta cagtgtttaa aggagtgcat
    34021 tacgagatag aattgaatga aaatggaaga ttgtggatac ttcataatac taaaaatgct
    34081 gaggttggga ctgaactagg catggatata tatccagaag atatccatat aatgagaaaa
    34141 gagaataact aagatgaaaa gaaaatcttt tttagcatat ccatatgtag tttggagtgc
    34201 gatatttgta ataattcctt taatattagt agtatttttt agttttacaa aagaatcagg
    34261 tggaggttat gcctttacac ttgagaatta taaagaagta attgacccta tatatatgaa
    34321 agtttttggg cgttctattc ttttagcagg aggagctaca ttaatatgcc ttatagttgg
    34381 ttatccagtg gcatatataa tttcaaaggc tcgtgtaagt agaagaggtt cattaatatt
    34441 attgtttatt cttcctatgt ggatgaactt tcttttaaga acatatgcat gggttgctat
    34501 attaggaaaa aatggacttt taaatacatt tttaggttgg tttggaatac aaccattagc
    34561 aattttgtat actaattttg ccatactttt aggtatggtg tataactttt taccatttat
    34621 ggttcttcca atatatacag cactatcaaa gatggataat gatttgataa acgctgctca
    34681 tgacttgggt gcaaataata tgacagtttt tagaaaaatt atatttcctt tgagtttgcc
    34741 aggtgtaatg tctggaataa ctatggtatt tatgccagca gtcactactt ttgcaatatc
    34801 aagactgtta ggtggaggta aaataatgct ggttggagat ttgattgaac aacagtttac
    34861 agttgttgga gattggaact ttggttcagc tatatcgata tttatgatga tagtaatatt
    34921 aatatctatg tctataatgt caaaatttgg agatgaatct gacaaagaag gcggtgggtt
    34981 actattttaa aattaaagaa aataacttct aatatatatt tagcattagt attcttattt
    35041 ttgtatgcac ccatatttgc tttggtacta ttttctttca atgattcaaa atcaatggca
    35101 agatggaatg gatttacatg gaagtggtat ggtcaattac ttcaaaatga gagtataatg
    35161 agtgctttat attatactat tgtaatagct atattagcgt ctgtaatatc tacaatagta
    35221 ggaactataa gtgctatagg aatacataag atgagaggta agagtaagaa attaatacta
    35281 aatgtaaact atcttcctat tttaaataca gagatagtta cagcagtagc tcttatgagt
    35341 ctgtttgtat ttgtaaaaat ggaatttgga tttacaacaa tgctattggc acatataatg
    35401 ttttgtttgc catacgttat actttcagtt ttgccaaaaa tgaagcaatt acctgataat
    35461 atagaagatg cagctatgga cttgggagca acacctatat acgctcttag aaaagtaatt
    35521 ttaccacaaa taaaaccagg tatagtttct ggatttttaa ttgcatttac tatgtcaata
    35581 gatgacttta taataagttt ctttaatgct ggaaatggtg taagcaatct ttctatagaa
    35641 atctatggaa tggctagaag aggtataaaa cctgaaataa atgcattatc aacaataatg
    35701 tttgcagtgg ttctaggttt acttttacta gctaataaaa aagaatctat agtaaggggg
    35761 attaaataat gattaagttt aaaaaagcaa tatcccttat agctgtaggt atgatgacag
    35821 ttactttatt tacaggatgt aataaagcaa ctgattctac aaaagtttta aatgtatata
    35881 atgttggaga ttatatagat gagtctctta tagataagtt tgaaaaagaa acaggaatag
    35941 atgttcaata ttcaacttat gatactaatg aaatgatgta tcaaaaagta aagagtggta
    36001 gtacacacta tgatttagta tttccttcag actatatggt agagaaaatg aaaaatgaag
    36061 gtcttttgga aaaattagat tttaagaata tacctaatat gaaatattta gataagagtt
    36121 ttttaaatcc tgtatacgac aaaactaatg aatatagtgt tgcatatatg tggggaactc
    36181 ttggaatact gtacaataag aaagaagtta aagaccctat ggatagctgg aatatacttt
    36241 ggaatccaaa gtataaggga aatataatga tgtttgactc tgttagagat actataggga
    36301 taactcttaa aaaattagga tatagcatga atagtgtaaa tccaaaagaa ataaatgaag
    36361 ctaaaaatct tttaatgaaa caaaaggatt tagtattggc ttatgtaaat gatgaaggta
    36421 aggatagatt gcttggtgga gaagtggcaa tgggtatgct gtattctgga gatgcagtta
    36481 cactaatgga gcaaaatcct gaccttgatt atgctatacc taaagaggga actaataaat
    36541 gggtagatgc tatgtgtgta cctacaacag cacaaaataa gaaagaagct gagctgttta
    36601 taaacttttt attagaccca gagaatgcaa aagtaaatgc tgagtacatt gggtattcaa
    36661 cacctaatac aggagcacta aaattattag acccagaaat aactcagaat cctgttgcat
    36721 atccatctaa agaagtgctt gataaatgtg aaacttttga agatattggt gaaaatataa
    36781 aattatatga caaggcttgg atagagttaa aatcaaaata gggtcttgtt ggtttaagta
    36841 aatttactta ataaatactt aataaaactg ttctttttta gaaaatttat tttctaatta
    36901 ttgaacagtt ttattttttg tttaagttat attcatatgc aatttaaata gtttattaat
    36961 aaatgaaaac ttatttgtat aatgacttta ataataatta gaaaaaatgg gcaacttaat
    37021 agaataattg gaggtgtaaa tttataaaaa atgaatagga taaataaaaa aatagattta
    37081 ttaatattgg ctttgctcgt ttttatattt ttaattgttg gaatagtaat actatcgatt
    37141 aggacagaaa ataaattgaa tgtgttcata atgttagcaa taattttttt tataataatg
    37201 ttaacttatt tatcaaattc agtagtgggg ttgataacaa gttcaataat tatatttatg
    37261 tatacatcct atattttata taacaatatt actcacaata tggatgttga atttatatca
    37321 tatatgtgga taatagcaac accagtatct tcaattataa tgggtaatct gaacaaaagc
    37381 ataaatgaat tgcaaaatac aaataaaaaa ctatctgaac agtataagga attagtgact
    37441 attgatagtg aaactggact tagaaattta aagatttttt ataatgatgt aaatatggag
    37501 ataagtaaat ctattagaca taatactgat ttttctctta tgatagtaaa attaccatac
    37561 tacggaaacc tacagactat atttggtgaa aacaaaacta ataaaatagt aaaatatatt
    37621 ggttcaaata ttatagaatg tacaagaaat gaagatataa tttatagttt acaaaaagat
    37681 atgataggga tactaatgcc aaatacatct ttggaaggtt caaaagttgt taaagacaga
    37741 ataaagaaaa ggataaaaga attaaattta gatttaaaca ataggggaaa atatgtaaat
    37801 atagatgtca aaattgcatt tttacaatat aagagtagtt ttggagatag tataaatttt
    37861 aagaatatag ttgaagagga acttcaatat gatgtttaaa atatttaata aaagtctatt
    37921 aaaattagta gttgtattat caatagtact gacaatatca aattttagct tatcttcata
    37981 tgcatcagaa attacttcca gcacagataa ggtattaatc atatatgatt ctaagaaaga
    38041 aacagcttat aatagagata ttttaaatat tatgaggact ctattgggaa gatttagttc
    38101 agatatagag ctattaaaat tgagtaacta tgatggtgag ataaataaaa attattacag
    38161 tcatatattt attttaggaa tcaatgaaaa ctcatataat aatgataaaa acactaaaaa
    38221 cttgattagt tccttaaatt tatataaagg aactatatgt tggttaggat atggtataga
    38281 aaatcttttg gaacataaaa aatacaattt agactatgta ggaaaaacaa acaatatagt
    38341 tagtgtaaat tatagaggta aatcatataa cttggatgaa cattatgttt ttaacattgt
    38401 agaatcaaaa gatacaagta ataaagtaat aggaagtatt aatgatacct taaataagta
    38461 tccatatata ataaatgata aaaatctttt ttatgtatca aaattagatt tagatggagt
    38521 tttattttat atattttgcg attcacttaa tgatattttt aatattaaga cgtttgataa
    38581 aggacgtata tttgtaagaa tagaagatgt acatgctttt agagaaccaa aaaatcttgt
    38641 agagatagcg gattatttaa gtagtaagaa tataccattt acgattgcat taataccagc
    38701 atatgtaaat cctaaaaatc ataaggtaat aactttatca gaaagccctg aaattgtcaa
    38761 agcaataaaa tatatgcaag ataaaggtgg aactgtgata ttgcatggat atactcatca
    38821 atacaagaaa gaagaagttt ctggagaagg gtatgaattt tgggatggta aaaaagatga
    38881 acccttaaaa gaaaatatga agatatttgt caaagataga gttttgaatg gtcttagagt
    38941 atgtatagag aatggaattt atcctcttgc atttgaagcg ccacattatg caatggaatc
    39001 agagggatat aaagaattaa aaaaatattt ttctacttat atagggcaac atcaaaataa
    39061 tgataaaaaa tttagcacaa atacatatcc ttatattatt agggatacag aggagtttaa
    39121 tatatttata cccgaaaatt taggatatat agacccagaa gataagttta cttttcaaaa
    39181 tataaaagaa aatttagata aattatccat tgtaagaggt tttagtggag ggttcttctt
    39241 tcattcatat ttaaacatag agtatctaaa aaacacaata gaatatttag aaaaacagaa
    39301 tatagaattt atgaatttaa gagattttaa taattgggta aaagttgatg aaatacaaat
    39361 aagaaataat ggagatgaaa ttatagtcaa ctatgataag gacttagatg aactaactaa
    39421 aagtgatact agatttaaat ccatatccaa tattagtaaa gttttaatat tcatagtatc
    39481 tataagtgtt ttaatatttg tgattatatt tatatatttt aagagaatag ataaaaagaa
    39541 atttttaaaa taaaggattt tatattagaa tcaatatttt aaaatatttt aggagaaatt
    39601 tatgagagat ttaaatgtat cagagtattt gttcgtattt agtttgttta gtatatggtc
    39661 tttattgctt ataaatatta ttttagctat gggtggatat atattttatt ttaaaaactt
    39721 tgataaagaa ataaaagaaa ttgatgaata tcctatgata tcaatacttg ttcctgctca
    39781 taatgaagct aaagtgatag gtagaactgt ggagtctttg ctattactca attatcctaa
    39841 gagtaagatg gaacttattg ttataaatga caattcttct gataatagta aagaaatttt
    39901 agaaaatata aaggataggt acaacaatta taatttcact ataataaata cagatagttt
    39961 aacaggtgga aaaggaaagt ctaatgcatt aaatattgga tatacgattt caaaaggaga
    40021 ttttatagct gtttatgatg cagataacac accagataaa aatgcactta ggtatctagt
    40081 acaaactata gtaatgaatg atgaattagg tgctgttatt gggaaattta ggactcgaaa
    40141 taaaaataaa aacctattaa ccaaatttat aaatatagaa acattaagct ttcaatggat
    40201 gtcacaagct ggtagatggc aactttttaa tctatgtaca ataccaggaa ctaactttat
    40261 attgaggaga agtatcatag aagaaattgg aggatgggat agtaaagcaa ttgcagaaga
    40321 tacagaaata agttttagga tatataaatt gggatacaag ataaagcttg taccacaatc
    40381 tataacatgg gaacaagagc cagaaactgt taaggtgtgg ataaagcaac gtactagatg
    40441 ggcaaaaggg aatatatatg tattaatgaa atatataaaa aatatattta aacagggaag
    40501 aaataagatt gtgtttgata tagcttactt tttttctgta tattttctat ttttaacatc
    40561 tgtaattata tccgatattt tatttgtttt aagtatatct aaactagtag aaatttctat
    40621 tccaattaac ttttttctaa tatggatact atcttatctt ttatttatta tagaagtgag
    40681 tataagcctt actatagaaa aaggtgaagc aacaattgaa aatatattca tagtggcaat
    40741 aatgtatttt acatactctc aactatggct gtttgtagct ataaaaggaa tgatagagta
    40801 tctaaaagat ataattttta aaagagaggt taaatggtat aaaacagaaa gattttgatt
    40861 catgtacagg aggaattaac atgaaaaaat ttattatatc aattatatct ttagtattgt
    40921 ttttttcaaa tatatcactt atatacaaag taaatgctga tgagactaaa gttaaaaatt
    40981 ataagtttga aagagatata actattgatg gtgttatagg aagtaatagt actttttttg
    41041 aagtaaataa aaattgggat attgaagaag ttttattgca tcttaatttt agtaagagcc
    41101 aaatattaaa tggagatgtt tcaagtttaa ctgtattgat aaataatgta ccaataaaat
    41161 ctattaaatt aaatgctaag acaaattata aaaatacatt agaagtatta gttccaaaag
    41221 attatataat tcaaggatat aatgaaataa aaataaaaac atacaaaaca atatctgata
    41281 aaatttgcca agatgattcc aatactggga actggatggt tattcacaaa gaatcatata
    41341 tatcaattag atataagcag aaaaaggtgg aaaactcaat aaatgaatat ccgtatccat
    41401 atgcagaaat tgaaaataat cataaattag atacaactat agtagtacca gataatatga
    41461 ctagaggaga gactacagca gtgtttaatt tggcatcagc atttggaaaa ataacaaaaa
    41521 atgatgattt aaagttagat gttaaattat attcagaaat gaaaaattgg tcagatgata
    41581 atattatata tattggtaaa cctgaaaata cagcagaaga aattttggat attttaagta
    41641 taaaggaaca aaccctatta tcttcaaact gtataatcaa gcaagtagat tcaccataca
    41701 ataagaataa gaagatgatg gtggtaattg gtagtaatga agatgattta ataaaggcat
    41761 caaatttatt aatagaaaat agactttcta accaagtttt atcatcatca gtacttgtaa
    41821 acaaagagac taatataaaa attaataggg aacaaaaatt aaatttaggt catttaacat
    41881 taaaagattt aggatattct gactttttgt tggaaggagc atttaatcaa caagctttgt
    41941 ttgatgtcaa aataccaacg ggtaaggtat tagatgatgg ttcaaagatt atcttaaatt
    42001 taagatattc tgacaattta gattttgaaa aatctttagt tacagtgtct ataaatgatg
    42061 ttattgtggg aagtaaaaaa ttggataggt cacattctaa taatgataag ttagaattaa
    42121 aaatacctaa agatatagat aataaaaact attatcaagt taaattgaca tttaatttga
    42181 gtataaaaaa ttcgaattgt gttactagag agagtaataa tccttgggca tatgtatcaa
    42241 ataattctta tttggcgtta tctacgaaag aaaatgaaac cttatctttt gaaaattatc
    42301 cgtatccatt tgttagagat gatgaattta atgatttaac tgtgataatg ccagattatt
    42361 cagggtcaca agctatgacc tggatgttta gattaggtgt tactttaggt gcgaatataa
    42421 attcacataa tggaaatata aatgtaatta gaggaaaaga atttagtgac aagtataagg
    42481 atactaatat tgtagttttt ggagtgccac ataataattc tgttataaag atgttaaata
    42541 ataatttaaa tataaagttc gataaaaatt actccaattt tatatcaaat gataagataa
    42601 gctttattga tgattatgga aaaaatattt ctactattca attaataaaa tcaccatata
    42661 ataatcaaaa aaatatcatg gtaattagtt caatgaatga aaaaaactta tatttaggaa
    42721 tggattattt gttgaataaa agtaaagtta atgatttaaa aggagataca ttgataattg
    42781 atgaatacgg agaggtagaa gatttagctt ataatttaaa atctaagaaa gaagtaaaag
    42841 attcaagttg gaatatgagt ataaataaga caactaaagt atttttaatg atttctttta
    42901 ttactataat tatagtcatg atattatcaa tgctatatat aaaaaaatat aaaagaagat
    42961 aatatgataa atttattatt ttaaaagagg tatataattt gaggaaatat atgaatgaat
    43021 ttaaattaaa aagaagtatt ttaatctcat taataatctt aatttttata tttatagttt
    43081 actttgtaag tattgagtta aaagatagga gtctagtaaa taatcaatat aaaggtaaga
    43141 ttaaatcggc caatttatct gtagattatg aaataaatca agttatgaag gatatagata
    43201 aattgggatt gaatacagta aatgtaccta taattataaa tgtagagtcc attaattctg
    43261 atattatgtc aatagataat aatagtaaag aaaaggcaat taagttaata aaaaaattaa
    43321 ataaaaaagg tatttcaaca atattagagg catatccatg gattgaaaat ggaaaattgt
    43381 atgagactga ctggaaccct ataaataaaa aaagattttt ttatacttgg caaaatgcca
    43441 tattaaatga acttataatt gatgtagcaa atccactgga tgtaaatgtt ttaaatattg
    43501 gttctaattt tgtacatttg gaagaatatc aacaaaattg gggtgaaata atagattttg
    43561 tacaatccaa atttgacggt cttgtaacgt acagaactaa ttggtggtat acaaaaaaag
    43621 atgatttaag tagtaagttg ttttatgaac aaaagctgaa caataatttt tttgataagt
    43681 tagattttat atctatagca gcatattttg agttaagtaa taaacctgtt aatacagtgg
    43741 atgaattaat ttctgcctta cactcatcta ctgtaaacaa tagaggacaa aatataaaac
    43801 aagaaatata taacctttat aaagctcata gaaaacctat attttttgga gaattaggtt
    43861 tttcaaatag agaaagtgca agttctcagc cgtggaatca tactccttca aaagctgtaa
    43921 atggcgaaga acaagcaagg tgttttgagg catataagaa agtttttgaa aatgaagact
    43981 ggataaatgg tttttctgtg ttttgtgtag gtaaaataga tgacgaaaaa aatttttacc
    44041 catcaaaaga gagtataaaa gttattaagt cttggtatga ataattttga aagtgtagaa
    44101 tttatataga ttaaatagat gattaggaga gatataaatg aatgacatca aggttatgac
    44161 tgtatttgga actagacctg aagctatcaa agtagcacct ttaataaagg aacttgaaaa
    44221 aagagagaat ataaaaagta ttgtttgcgt tacagctcaa catagagaaa tgcttgacca
    44281 agttatagaa acctttaata taaatgtaga ctatgatttg gatataatgg aaaaaggaca
    44341 aagcctgaat gatataacat gtaagatttt aaataaactt cccttgattt taaacaagga
    44401 aaatccaaat ataatattgg tacatggaga tacaaccaca actctagcta caagtttgac
    44461 tgcattttat aataaaactc ttgttggtca tatagaagct gggcttagaa cctatgataa
    44521 atattctcct tttccagagg agctaaatag acaacttaca ggtattattg ctgatatgca
    44581 ctttgctcct actaatttgg ctagaaaaaa cttgatttct gaaggaaaac ctaataataa
    44641 tatatttgta actggtaata ctgctattga tgctttaaag atgacaataa aagaaaacta
    44701 taatcatcct ataattgatg agattggtaa cgataggatg attttgttaa cctctcacag
    44761 aagagaaaat ttgggtaaac ctatgaaaaa tatattcaga gctataaagc gaatagtaga
    44821 tgactttgaa gatgtacaga tagtatatcc catacattta aatcctaaaa tacgaactat
    44881 agctgatgag atatttggaa aatttcctga aaaaattcat attatagagc ctttagatgt
    44941 agctgatttt cataactttt taaataaatc ttatatgata atgactgata gtggaggaat
    45001 acaggaagaa gctccatcat taggtaagcc agttcttgtg ttgcgtgata aaacagaaag
    45061 aacagaagga attgaagcaa agacacttaa attagtaggt actaatgaag atagaatata
    45121 taattcagtg agcgatttat taataaataa agataactat gttcagatga gtaaagcatc
    45181 taatccatat ggagatggaa atgcaagcaa atatatagtg gatataataa ttaaaaaatt
    45241 taattgcaaa tatttaaatt agataaggcc taaaacatta actaattgat ataagattta
    45301 tgataatatt aaggaataca atttttaagg gggagtaata tggctagaaa attaataaaa
    45361 aatttgggta aaagtaaaag tgtaaagaga gtgaaacttt tatttaagaa gatttttatt
    45421 actgtattca tagtagcaag tatagttgct atttttaata taacgaaata ttttgaggaa
    45481 ttatacaaag taagggattt aaaaagtact aaaattgaat actatatgga tgtggctgat
    45541 gaagcaggag atggaaaggt ccaattaagt tggaaggcct tacttgctat agacatggta
    45601 atacatgatg aagatttaag taatataaaa aagaaagaca cattggatat aggggaaaag
    45661 tttatagtag aagataaaaa tggtaaaggc gaaaaggtgt ataaggtaaa aaagtttaat
    45721 aaggtattaa gcgaattgaa atttgactct tctcaaaaaa gtagagcaag aaaatacatg
    45781 aaagatttag aatacacata ccttggaaat aaacaattag atagtagtga tgaaaaaatt
    45841 aaatttataa agaagttaga agactcagct ataagagaat atattgatta tggaatattg
    45901 ccctctataa caattggaca agctatatta gaatctggtt ggggaaattc taaacttaca
    45961 aaacagagta ataatttatt tggtataaaa gcagataaag catggaaagg aaaaagtgta
    46021 gaaatttcaa cttcagagca ttataatgaa aaaattgtag ctagttttag gtcgtataat
    46081 tcattacaag attctgtcaa agaccacagt ttatttttaa ttaataataa aagatataga
    46141 aaacatgggt tgtttgaggc aaaagattat attagtcaag ctcaagcatt agaaaatgca
    46201 ggatatagta cagcagaaga taaaaaagga aatcgtatat atgcagagct attaatagat
    46261 gttattagga gttataattt gcaattgata gataataaag ttgagacaaa ataattgtta
    46321 actttatatg aggagataac aagataagat ttttttctac aaaaagaata gaaaaattgt
    46381 aaaaaaaact aaaaaaatgt attgacttgt tatttaaaag gtgatattat tattactgta
    46441 ctcgaaagag aacaaaa
//
LOCUS       DAEHWM010000023        45864 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.024, whole genome shotgun sequence.
ACCESSION   DAEHWM010000023 DAEHWM010000000
VERSION     DAEHWM010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 45864)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 45864)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..45864
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.024"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            207..1424
                     /locus_tag="KNP36_001347"
     CDS             207..1424
                     /locus_tag="KNP36_001347"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase"
                     /protein_id="HBF0873230.1"
                     /translation="MMNVTLTDVKEARETIKNIVKRTDLLESVKLSEKTGANVFYKCE
                     NLQKTGSFKLRGACNKIASLTDEEKANGVIASSAGNHAQGVALGAKMTGIKSTIVMPA
                     TAPLAKVSATKGYGAEVVLNGAVYDDAYAKAVEIQKETGATFLHPFNDKYVIAGQGTI
                     SLEIFEQLDNKVDTILCPVGGGGIISGVAVAAKALNPNVKIVGVQTANIPSMKESIKN
                     GKVTTAFNDTTIADGIAVKTPGDLTFEIINELVDEIVVVEETEIAESILFMMESQKIV
                     SEGAGAVCTAAILSGKYVPAKDENVVCIISGGNIDINTLYRIIGVALAKEGRRYSFST
                     IMEDKPGNFAELTRIISENGGNILSANQGKLSAGEALGKQSAEFILETIDYDHIARIK
                     KAIEEKGFKIIEL"
     gene            1519..1899
                     /locus_tag="KNP36_001348"
     CDS             1519..1899
                     /locus_tag="KNP36_001348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBF0873231.1"
                     /translation="MKHEVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVV
                     EGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYFGENKP
                     ARACVEVARLPKDVKVEIEVIAVL"
     gene            2183..2665
                     /locus_tag="KNP36_001349"
     CDS             2183..2665
                     /locus_tag="KNP36_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0873232.1"
                     /translation="MLNFFKKNKSYKLHAVVSGNSINIEKVNDSVFSKKLMGDGVAII
                     PNSNVVVAPCNGKVTVLTESKHAFGMVSDEGVEILVHIGIDTVSLQGEGFKNEVSQGD
                     TVKKGSPIISFEREKINSQGIDCTTIIIVLNHSEFSEINCMVENEVVAGQDTVIEIMK
                     "
     gene            2686..3501
                     /locus_tag="KNP36_001350"
     CDS             2686..3501
                     /locus_tag="KNP36_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0873233.1"
                     /translation="MRVVKIFNNNALSTVTNDRKEAILLGLGIGFNKRPGDKVNEDKI
                     EKIYYVQDHMQTKFLELLKNVSPEVMDASQQIISLIPGNEGKFNNKGILSLVEHISFA
                     IDRMKNNVFLPNLMLLDIKMMYSKEFELGVKALEIIYRVCHIHLPEDEAGYIALHFVN
                     LQSNDNLAYDTLKFVKGSIDLIKECYGLELDESSLSTLRFRTHLKFLAQRIFKNEICQ
                     DDKMIEMYDYLINNHPKNKEYLEKLNVYIEKEFRYKLDKPEKIYLLLHLTKIL"
     gene            3552..5102
                     /locus_tag="KNP36_001351"
     CDS             3552..5102
                     /locus_tag="KNP36_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0873234.1"
                     /translation="MKEKLLGGLETFAKAMVQPLMYLSSAGILMVVGVLLTNDMLLGV
                     LPFFKWEPIQIFGSLIYNCIMAIINNLAVIFAIGIPAALAKKEKHKAALIGFMSYIIY
                     LTASNTMLTSLGQLAKESKMLGLIGTGQATILGIQVVDTSVFGGIILGCIAGYVFNRT
                     SNKTFKGALQIYSGANFSFICMFFVSILIGVVSNFIWPLAQQGIASLANVIKDTGTFG
                     LFLYGFLERILVPTGLHHLIYTPFQFSDLGGVLKVGADTVSGAYAIVMTEMNLPVERF
                     SDSIYYMATGFTKMFGYIGIGAAFIYTAYKQNKKKVKATIIPLIITAVLASVTEPLDF
                     MFVFCAPFLFFVHAVIAGLFIALLKIFDVTALCGGNLLVSIIMNTTVGVEKTHWPVMM
                     ILGLAQIIVYFVVFSFLIKKFNYKTPGREDESTATGEEQSKQLNLDAGIENIIDGLGG
                     KENINTVENCITRLRVNVKDESKINEDIINLTPNSGIVRKGKDIQIIFGLHVHEVRRA
                     VEDFLEAY"
     gene            5199..6551
                     /locus_tag="KNP36_001352"
     CDS             5199..6551
                     /locus_tag="KNP36_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-alpha-glucosidase"
                     /protein_id="HBF0873235.1"
                     /translation="MIITIVGGGSTFTPGIVKSIALREKELELEEIRLFDIDKERQDK
                     VAVVVNWILKEDVKTDVKLTVTNCEKEAYTDATFIFAQMRVGKYEMREQDEKIPLKYG
                     CVGQETCGCGGMAYGLRTIQPMIKVIDDVEKYAKKDYWILNYSNPAAIVSEACRKLRP
                     NARIINICDMPIAIIDMIAGSLNINDVHNIRYDYFGLNHFGWFTSIDYKHRDLMEEIK
                     EYIKENKILLPKSYIENLNKSRSTGNRHAVSSWIHVWESVYTMLESFPKYLPNTYLTY
                     YLLSKETVEHSNINRTRANEVMESREKDLFEGVRHYLETGEISEKAFYAGSHGDWISD
                     LAVSIKNDTRSRFLVITENRGAIPNMPYDAMVEIPAYIGKDGPEVIARGPIPLFQQGL
                     MMQQLNSEKLIVEAYIENSYEKALQAFTLNKTIPSMNVAKEILDEMIEVNKEYWPELR
                     "
     gene            6682..7440
                     /locus_tag="KNP36_001353"
     CDS             6682..7440
                     /locus_tag="KNP36_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873236.1"
                     /translation="MNIINKIFWEEDRIGMITNNLEADTHSHCMLQLFLGIEDSIEIT
                     VNEKLVKCNCIIVDKNISHSFSARKKVYYSAIIEPTSIYAEQLTSKMNDFGYWICDND
                     GLEKLRQQGTFLIDNSSKEQYLRFMEMLNNYLNIPITLKHYDDRITELLNLLRTCNCD
                     NHTISSFADKVSLSASRLSHLFKEQIGIPLKSYILFHQMECAFRELLSGKNVTEASMT
                     AGFDTPSHFAGTVKRMMGMPVSLSLKDSEFLKVY"
     gene            7487..8206
                     /locus_tag="KNP36_001354"
     CDS             7487..8206
                     /locus_tag="KNP36_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglutaminase domain-containing protein"
                     /protein_id="HBF0873237.1"
                     /translation="MNKEYLEETKMLNYNEPQLKLLVSSKNWLELDDFHKIKSIYEFV
                     QNDILFGYNASDMLSATQVLNDGMGQCNTKATLLMALLRAVNIPCRLHAFDVTKDFQR
                     GATSKLISLLAPKYILHTWVEVFYQDRWIALEGVITDKKYLEAIQKKFFNHGGTFKKY
                     AIATNDLKNTSIDWDGKDTFIQKEAIVYDYGIFPSPDVFFSTHSQHMSKLKNFIYVHL
                     IRKIMTKNVCKARNNYIDKNE"
     gene            complement(8330..9730)
                     /locus_tag="KNP36_001355"
     CDS             complement(8330..9730)
                     /locus_tag="KNP36_001355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HBF0873238.1"
                     /translation="METQSNNKKGNLIIAIVMTGAFISSLSQTLLSTALPNIMSDFKI
                     TADIGQWLTTIYLLIAGIIVPTTAYLINRFSTRKLFITSMSIFSIGCIIALFSNNFST
                     MLIARVLQAMGSGSLMPLLQVIILYLCPEEKRGAAMSLVGITVGFAPAIGPTLSGWLV
                     DSFGWHSLFLFLSPIAILDVILSFILLRNVGETQKLKLDIPSIVLSSLGFGGLLIGFT
                     NQGNYGWTNIATYLPILIGIMSLILFTLRQLKSKEPFLELRVFKNKPFLISTILIMIV
                     YASMMSATLMIPLYVQSVRGFSALSSGSLMLPGAILMVVLNPIAGRHLDKYGPHALSI
                     LGTGCLFLGTLSFAFLGRDTSLIHVSLMYCIRMIGISMVLMPLTTWGIKTLDRELISH
                     ATAINNTLRQISGAIGSAILITIMTSATKKAHMSSNMLSNIHGIDVAFSIAATLAFTG
                     LIVSICFIKRHQIIRS"
     gene            complement(9734..10642)
                     /locus_tag="KNP36_001356"
     CDS             complement(9734..10642)
                     /locus_tag="KNP36_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0873239.1"
                     /translation="MKGDNKVTEKQRLIITIAQKIFDQKGFQNTSISDVVKECKMSKA
                     TFYKHFETKESFICEIINYYDEKFLEIIHSINENNDIPSSEKLNRKIIAVWKNIFSRT
                     TINTYIRENFSEEQRKATSKLQTKSRANLLNEYKLSLFDNYGDKIEKIIFDLVFLLDA
                     LIHQFIYIIHVQKREINVYFIAKFTIQILDLVVENMDNLNPLIEKSMFLHKQEDEVYF
                     SLHNKSLFFKTIQDIEELIKTDTSLLENPKLLEAIKKLYVEGKNQQYDSLIMDAMIAY
                     LEKEDTLRPKVLLLNSIKNQLKKETL"
     gene            10903..11550
                     /locus_tag="KNP36_001357"
     CDS             10903..11550
                     /locus_tag="KNP36_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBF0873240.1"
                     /translation="MKKKICVAIIFALFIVFVEMFIDSSSEGSKIMTAELSKYRKGVN
                     VLSINNIIVANKKYSLPKDYSPQESSEARDAFYKMNKDAQKSGLNLKAFSTYRSYEYQ
                     DRLFKSYVKEHGEKEANRFSAKPGESEHQTGLAFDIGGDDQSCWANKKFNNTKEAKWL
                     YENAYKYGFILRYPEGKENITGYMYESWHYRYVGTEHSKNFAMNNLTLEEYLHIN"
     gene            11875..14514
                     /locus_tag="KNP36_001358"
     CDS             11875..14514
                     /locus_tag="KNP36_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HBF0873241.1"
                     /translation="MSYKSTYQEVIKNLDSSLSGLSKERAEELLEKNGANELKEADKV
                     PTYKLFLESFKDPLVIILLIAALVQIFLGETVESIIIFAVIIINSVLGVVQTKKAESS
                     LESLKNLSAPNAKVIRDNKKMTIPAKNLVVGDIVFLEAGDYIPADGRLIEAQSLKVVE
                     GMLTGESEPVLKHIEKISEDVSLGDQKNMVFSGAVVVYGRGSFVVTGTGMNTEMGKIA
                     GLLESAENKLTPLQQKIEDFSKKLGVGIVILALLIFIIQVARNYFMAGNGEMTQIILD
                     SFMFSVAVAVAAIPEALSSIVTIVLAVGTNSMAKKQAIIRKLPAVETLGSTSVICTDK
                     TGTLTQNKMTVVDYYMYGTNNDELDKEKVNYSYHAKLLTMVSTLCNDSHITSDGKEVG
                     DPTEVALINYSSKNDLDYDKLRSKYIRINEIPFDSDRKLMSTVNSIYGDYIMFTKGAP
                     DIVFSRCKYALKNGSKVDITDEIIEEYKHKNEEFSNRALRVLAFAIKDVPEEDFIPSI
                     DDEHDMTLVGIMAMIDPPREEVMDAVKEAKSAGIKTVMITGDHKTTAAAIAKEIGIME
                     EGDLALTGKELDALSEEQLYEKLENISVYARVSPENKIRIVKAWQHKNNITAMTGDGV
                     NDAPALKQADIGIGMGSGTDVAKDASAMVLVDDNFASIVNAVEVGRTVYSNIIKSITY
                     LFAGNLGAIVSIVFAVFAGWSNPFTALQLLFINLVNDSLPAIALGFEKSEKNIMNKPP
                     RHPDESILAGGTLKAVAIRGCIIGVVTIIAQYIGLQVSPELGVAMAFSTLILARIMQT
                     LPARSNNQTVIKLGFFSNKYVIGAVLVCLGLYSLTLIPVLRGIFSIPTTFGLYQLGIC
                     LGLALISSILMELNKLINRSEVK"
     gene            complement(14572..15675)
                     /locus_tag="KNP36_001359"
     CDS             complement(14572..15675)
                     /locus_tag="KNP36_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate aminotransferase family
                     protein"
                     /protein_id="HBF0873242.1"
                     /translation="MKLKINKAIEMQLKKSYAIESGHSEDVFEIDCGEGINTVSYSNK
                     AVEAFNALKFDMIRGYPHSIALKDNIVDYWKDFIALDTDRICLADGSIHVIYLLNRLF
                     IEKGDKVLGYSPQFSEYETDIKMHGATYDYVLLKKEDNFKFNEKEFIEKINPEYKVIY
                     IDNPNNPTGQIIPLSSIENIVREAAKYDIAVMVDEAYGEYMPKENSAVKLLNNYDNVI
                     ALKTFSKGFGLAGLRAGYAVLPEQLVSPIKKISTPYEVSEISRSIAANLLDDVQFIEE
                     LKEKTKDIKNQLLIPWKNLNIAETSDTVSIMTVEHKNKDIDLQQEFAKLKIRVISGSD
                     FTGLDKNFIRFRMPEEKELPEVIKAFQIIDNIE"
     gene            16035..16856
                     /locus_tag="KNP36_001360"
     CDS             16035..16856
                     /locus_tag="KNP36_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBF0873243.1"
                     /translation="MGYKLIVTDMDGTLLGNNHKVTDENKTALQKVIKSGINVTLATG
                     RAFDSAKCNVDFLKEDMPIIACNGSLIREQNGNIIYSNKIDTRTCLNILDVLDKYDIY
                     YQCNSIDSMLSKKIEGREDRLSVFLGSETEVIVKDDLREEIFKKDILKFVIIEEKNPS
                     ILDEIRKELRKVQGIKITSSWPNNIEVMNEGVDKGNAVKILAEKMNIDREDIIAFGDN
                     YNDIEMIKFAGLGVAMGNAEELIKQEADYVTDTNQDSGVAKAIYKFLELKESLSS"
     misc_binding    16935..17146
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            17233..18549
                     /gene="argH"
                     /locus_tag="KNP36_001361"
     CDS             17233..18549
                     /gene="argH"
                     /locus_tag="KNP36_001361"
                     /EC_number="4.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HBF0873244.1"
                     /translation="MKLWGGRFRKAENQLMEEFNKSFGYDCVLYKKDIEGSVAHVHMQ
                     VKCGLLTEEEGKSITEGLKGILEDVENGKLVLDGEYEDIHSFTEINLIQRIGDVGKKL
                     HTARSRNDQVAVDMRLYAKEKANDLVDLISEFKATIKDVADKNPVMMPGYTHLQRAQV
                     VTFKHHLMAYYSMFDRDEKRIKNAIEILDESPLGCGALAGTTHDIDRSITCEQLGFKK
                     VVDNFMDGVSDRDYLLELMSDFSIIMMHLSRLSEELILWSSQEFGFVEIDDLYTTGSS
                     IMPQKKNPDGAELIRGKTGRVYGNLFGLFTVMKGIPLAYNKDMQEDKEGFFDSVHTLE
                     MCIQIMDRMIATLKVNEDKMKQAVKNGFLNATEVADYLVKNNVAFRDAHGIVGSIVIY
                     CEDNKKAIEDLTLEELQKFSDAFKEDIYDFIDYESILNKGIKKNLK"
     gene            18798..19136
                     /locus_tag="KNP36_001362"
     CDS             18798..19136
                     /locus_tag="KNP36_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2325 domain-containing protein"
                     /protein_id="HBF0873245.1"
                     /translation="MNLLVIGGHERMEKDYMVMAKKKGYKTKVYTTMSSKLNNSIGKP
                     DAVVILTSTVSHKMSRTVESQAKKQDILIVRHKNSSKVAFNECLDMVDECLGNCSKCK
                     LKDKQKQKNI"
     gene            complement(19263..20552)
                     /locus_tag="KNP36_001363"
     CDS             complement(19263..20552)
                     /locus_tag="KNP36_001363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBF0873246.1"
                     /translation="MKRNLSLLLICLLIFTSFLGSSNISFADNEPAIVAKHAVLMDYE
                     SGKILYNKDGNSKLYPASTTKVWTACLVLKEVKDLNQVIEIKDLPQIDGSSMYLKNGE
                     SFTVKQLLDALLVHSANDAAFVLARYVGGGNVQKFIDLMNSEAKKIGATNTHFNNPHG
                     LPDPNHYTTAHDMALIAREAMNNDTFRQIVKTKSLKFEATKAYPYERYFVNTNKFLTS
                     HDKITYKGQPINIKYDIVDGIKTGYTDAAGKCLLSSAVKDGRRVIVAVFNSTNADLYL
                     DSRILIDYGFDNFKCATIVDKEKYTDTKKVLFTKQHELIYEPKNSYRIFLEKDESQGN
                     YDTKTELNKIDLPIKKGAKVGTLNVYNNGKLENSIDLIAKNNLDSSLPFLTENNVLMT
                     FVKIIAGILVLLVLFIIASNIKKKKRKKARSKKNMKK"
     gene            20632..21336
                     /locus_tag="KNP36_001364"
     CDS             20632..21336
                     /locus_tag="KNP36_001364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HBF0873247.1"
                     /translation="MKKKVKFISFFVLFILIISSIIVYKSLIFKDDIYVVSKKNLPNE
                     KTHVVENEIKGEDNNHSKVTKDIDKNFQNNKITIYISGAVNRPGIVTIESDKRLYDAV
                     ELLGGTTKEADLNGVNLSVRLEDEQHYIIPKIGEATSVTSNDDSNKLNQKNESRGEPK
                     NKSNKNISNESKVNINVATIEELDSLPGVGEATANKILQHREENGQFSSIEEIKNVNG
                     IGDKKYENIKDLICVD"
     gene            21428..22474
                     /gene="selD"
                     /locus_tag="KNP36_001365"
     CDS             21428..22474
                     /gene="selD"
                     /locus_tag="KNP36_001365"
                     /EC_number="2.7.9.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015617929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:21476..21478,aa:Sec)
                     /transl_table=11
                     /product="selenide, water dikinase SelD"
                     /protein_id="HBF0873248.1"
                     /translation="MKKEQKKLTEMTTAGGUAAKIGPEVLASVLSQLPKNDNIENLLV
                     GLDTADDAAVYKLNDDMALIQTLDFFTPMVDDPYVFGQIAASNSLSDVYAMGGKPLVA
                     MNIVCFPSCHDMDVLAEILKGGFDKVKESGALLVGGHTVDDKEPKYGLSVSGIVSPNK
                     VLSNATAKPGDKLIITKPIGVGVLNTAMKEGMVEQHIADKVIEIMIHLNKYAAMSFEK
                     FDVNSVTDITGFGLLGHTLEMAKASEVSIEIESKHVPIIEGAIEMAQMGIIPAGMYKN
                     MHYVSKDVEVVGNIEVAVQDILYDPQTSGGLLISVKEELAEELVKDMKLNGAIEAKII
                     GSVVPKGEKYITVL"
     gene            22492..23904
                     /locus_tag="KNP36_001366"
     CDS             22492..23904
                     /locus_tag="KNP36_001366"
                     /EC_number="2.9.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-seryl-tRNA(Sec) selenium transferase"
                     /protein_id="HBF0873249.1"
                     /translation="MIVLSKRELFAMLPSVDEVLSDNRIVEIINEYPRSLVLESVREV
                     IDLKRQFILRLKEDASNSVTIEFGEIIESAIERVKLNYSLSLKKVINATGTVIHTNLG
                     RSLLSEDIKDELWCAASRYSNLEYDLDNGERGSRYSHLTSTIKRLTGAEDVLVVNNNA
                     AAVLLVLSTMAKGGEAIVSRGELVEVGGSFRIPSIMALSGAELVEVGSTNKTHLKDYK
                     EAITEDTNVLMKVHTSNYRIMGFTESVSIEELVNLGKKYKLPVIEDLGSGVFIDLSKY
                     GLSYEPTVLDSIRQGADVVTFSGDKMLGGPQAGIIVGKKEYIEKMKKNQLTRALRVDK
                     LTICALEATLRMYLDETKAIENIPTLKMLTYKIEELEVKANKLFEKITALNLNANINI
                     EDGFSQVGGGSMPLETISTKVISITPEHMNVSSLEKKLRLSEAHIIARVYDNKYVLDV
                     RTIFDDEFDVIVEELRKAFN"
     gene            24018..25901
                     /gene="selB"
                     /locus_tag="KNP36_001367"
     CDS             24018..25901
                     /gene="selB"
                     /locus_tag="KNP36_001367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="selenocysteine-specific translation elongation
                     factor"
                     /protein_id="HBF0873250.1"
                     /translation="MKNVVIGTAGHIDHGKTTLIKALTGRETDTLDEEKKRGISINLG
                     FTYFDLPNNRRAGIVDVPGHEKFIKNMLAGASGIDIVLLVVAADEGVMPQTVEHLDIL
                     SFLNIKNGIVVLTKSDTVDDEFRELVKEDICEKIKGTFLEDAEIIEVDSISKRGIDTL
                     IEKIDKMSDDIEDKNENSPARLNIDRVFSIKGFGTVITGTLIEGKISIEDDLVIYPQV
                     LKTKIRSIQVHGENKDTAYAGQRTAINISNVKVDDIKRGDVLAAPNSLEESMMLDVKL
                     SLVNHLDKGLKHWDRLRLYHGTREILCRAVPLDKELIESGESGYVQLRLEESIVSKKG
                     DTFVVRRYSPMETIGGGVIIDPSPKKHKKFDEKVIEALKIKEKGELKDIIEEYLKRNL
                     KNYPNIKEIMSYSGAHEEDVKRALETLISEDKVFIIGNMYMHINQYNKLKENTIKLLS
                     EYHKKYRLRKGILKEEVRSKIESNFKTREMDILLEKLSTENAIKIENNIVSLLDFEVI
                     LNDKQKEIAKKIEKRLKSCGVSSILTIDEVSEGNHNYAEVLESMIGNKVEKLDDLYIM
                     DKDIYENAKNILINYIKENKEITLGEYRDLIDSSRKNCMIILENFDRNKITKRVENKR
                     ILF"
     gene            26006..28744
                     /locus_tag="KNP36_001368"
     CDS             26006..28744
                     /locus_tag="KNP36_001368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation-associated two-component system
                     sensor histidine kinase"
                     /protein_id="HBF0873251.1"
                     /translation="MKNIIPDVKPDIKEREDMSLLFIIMGSVLLLFIIKDIEKYETLL
                     HAIYTIFLVATGVIIFNTTKFKVDSFSTFLGLIFIATGVLECIYLFNSLGIKTKSIME
                     INITISAITDLFPILGVYLSFKFVKDNKQIYSSVILFIATATLTITSLFIISGICDYL
                     GNGKSQYALGVIISIFIIIISIISGIELNSSSNKGKWEYDEKKIFNRIIVIIILSRVP
                     NLLHIVIDNRNVERILSQIIINVALYYLYNYIVSKNIKKTALELHDTNEELTKKTESL
                     KEKNKKLIYETEKIEELKGILMKRESRLQSTLDVAVNSIVVFSKDGEITYANKSFRNT
                     FGDYKEQDKLTDKIKNFNDLIESIHYVFVHEKNAEKLISTSDNKVYQAIFAPLIIASQ
                     TEGVLCVLEDKTKKKEYERKLIEANKRSKDFLESIGDGIVVLEGNNKIYVNNACREIF
                     KNNLESIDFSLVCKSEESIEKRYVIDGEVKYVEMSFSQYTNAGTNKTIIVIRDTTSRK
                     ISQIKLEESQSSYSRFIDILPDGICLLKEDLSINYANKSFLDMLAFTNIDDIKDSNIK
                     LLMNANTEEKMKFTDNMAKVLNENRSILLLEHELINSYDDIVEVELSALPFAIYNTRY
                     IMLIIKDLVHKKYSEQAEKELLERFKTDKIKTEFFANMSHELKTPLNVISSSNQLVDS
                     FYRNEKIKDYNNNIKSHVDLVRQSSYRLQRLINNIIDLTKMESGFYTLKLAKYNIVSV
                     IEDLFMNIEEYALRKDIKILFDTDLEEINVYIDKVEIERIMLNLLSNCIKFTDNGGWI
                     YVSIHYKIDKVIISVKDTGVGIPQDKLELIFEEFSQVDKTLSRNTEGSGIGLAIVKNL
                     VSLHGGDIEVVSEVNKGTEFLISLPMKGFSSEHYTEDKRIYNIQEKIKIEFSDIYY"
     gene            complement(28863..29807)
                     /gene="manA"
                     /locus_tag="KNP36_001369"
     CDS             complement(28863..29807)
                     /gene="manA"
                     /locus_tag="KNP36_001369"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HBF0873252.1"
                     /translation="MEPLFLKPIFMDRIWGGTALKDKFNYEIDSPTTGECWAISSHKN
                     GDCLIENGKYKGKKLSELWNKNRELFGNTPGDKFPLLTKILDANDNLSVQVHPNDEYA
                     KKNENGELGKTECWYVIDCSDDAEIIIGHNAKSHKEFVNMVNNNEWDKLLRKVNIKKG
                     DFFYVPSGTIHAICKGTLILETQQNSDTTYRVYDYDRTDNSGNKRELHVQKSIDVTNV
                     PHINFDTDYKIVSTSDFKCTTFVSNEFFSVYKLDVFGKCNFTHNTPFSLYSVLDGNGK
                     LIHNSVEYNLKKGMHFILPNDFGDFSFEGNLEIICSHI"
     gene            29980..31341
                     /locus_tag="KNP36_001370"
     CDS             29980..31341
                     /locus_tag="KNP36_001370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0873253.1"
                     /translation="MELFKAESKKYKKEFLKLLEQWVSIPSFYDRKTVSKDMPFGKGV
                     YDALNWFENLGRENNFKVKNIDNHAVQIEYGNGKEYVDIFGHCDVVNPGEGWDSEPFK
                     LNIIGDKLVARGVSDNKGPMIVNFLALKMIKDLDINLKRKVRLIAGGNEESGFKCIKH
                     YYSKEPYGVCGFTPDAKFPVLNGEKGGAIIKLISNIDDKSLYISGGIEFNTIPDKVYI
                     KNVEKLGKDNICFDINNISINYDNGNYIVYGKGGHSSKPEKSINPILATIKLLSENID
                     EKWTKDLYKLINQDNINGNLFGLNIEGKCGILSMVPTIINIVDGKLEVVLSVRYPEIL
                     TIEDIIKKFNLYMEQNNINKFELIGENLKQANYIDRNSKLVRSLHDIYIKYSGDLKND
                     VRVTSAGSYASEMNNSVIFGCEFPDGSFGNVHSANEFASLDRFITAIGIYAEAIITLC
                     NKI"
     gene            31429..33318
                     /locus_tag="KNP36_001371"
     CDS             31429..33318
                     /locus_tag="KNP36_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0873254.1"
                     /translation="MITKKHAIIVKSLSNKDGYMTSNELAIKLDVSTKTIKRYIADLN
                     SVLSKYDLVIASSRGIGYKLSGSKNNIARAVKEANKYIDGFLDDSEESRMSNIICMLI
                     NRNYMSIEAMAEELNLSIAAINKLSSKLKRKLEKYDLVIKSKPYYGSYIHGEEINIRQ
                     LITDYAIKLDEKSKVKVFLDDISENDIHCIESILEKHLREKDTIISDKDFNLLLSKII
                     VSVFRSKRGHSNNINLMDTSYRFHNYYFIENLMKEISDKIGFKLIEDEVIYISNYSGV
                     IAYKGTQGRKNTSEIEERISSVISSALQDIFLISGSDYTKDDEFMVAISDHIKRFLNR
                     ARANVKSNNPLLHQIKEKFPIAFNLAVFLSNKLETEFNLKLDEDELGYIAIHFAASNE
                     RMKKNTSKKICIVCHYGIGTGQLISEKLKQNISDLSVVGVYPVRYLDMAISQDVDLIV
                     STVELKGYEKPVLYIENIFDDSLIENVNKAFYEKEERRKIISNMFDEKAFFSIKANTK
                     EEVIISLSNKLKERDFIEESSIKSIIDRENISSTEIGNLVAIPHTIVKGDKKSIIGVG
                     ILENPIIWDKQEVQLVFMVFFNTKEKHNFSIFKYLYNFIKDEGGVRGIIKICDFNKLM
                     ALIGN"
     gene            33333..33788
                     /locus_tag="KNP36_001372"
     CDS             33333..33788
                     /locus_tag="KNP36_001372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0873255.1"
                     /translation="MGTNIFNKEYVFLNVDAKSKVEVLKFISKKAKDLNLAEDESLVY
                     EGLMAREEQFTTNLGESIAIPHTKNDAIENPAVVVLKFNEDVVWNEGEDKVKLAISLL
                     MPGKSKENIHLKLLSSLSRKLINKEFKDSLLKSDNVEEISNLINEALGL"
     gene            33847..34164
                     /locus_tag="KNP36_001373"
     CDS             33847..34164
                     /locus_tag="KNP36_001373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_311294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBF0873256.1"
                     /translation="MNKKLVALCACPMGLAHTFMAAEAIEQAAKALGYEAKVETQGAD
                     GVQNELTRDDILGATMIIHAVAITPEGMERFDGCEVYEVELQEAIKNAEGVIKEIEED
                     LGI"
     gene            34189..35451
                     /locus_tag="KNP36_001374"
     CDS             34189..35451
                     /locus_tag="KNP36_001374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBF0873257.1"
                     /translation="MAIKKKVINSSGASTTGGNNVGKSTPSSPTQSKGNGKWKEISKH
                     IMTGISYMIPVLVMGGLIGALSQLIPYAILGLDPSVGIVDAMNSGEFTGFKLSLLNIA
                     QLMSNFGFTLFGFAIPLFAAFCANSIGGKTALIAGFIGGYIANKPVGVPQFVDGQWTE
                     VVPVASGFLGAILIAFIIGYFVKWLNKSIKVSHNWLAFKTTFLIPLIASLACMVLMIF
                     IITPFGGLINESMKNFLTAAGAAGEYVYATALAAATAFDLGGPINKAAGFVALGLTTE
                     NVLPITARTIAIVVPPIGLGLTTLLDKRLVGRRVYDRQFYQAGKTSIFLSFMGISEGA
                     IPFALERPGFVIPLNIVGSVIGAITGIILGAIQWFPESAIWAWPLVDNLFGYIIGIAV
                     GAIFIAVGNIFYRNKLIKDGKLVVDYID"
     gene            35556..36620
                     /locus_tag="KNP36_001375"
     CDS             35556..36620
                     /locus_tag="KNP36_001375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0873258.1"
                     /translation="MDKIEKVREYFREYDIDGFLINSPTNKFYVGNLFSSSGYVFITK
                     ESQYIIVDFRYFEEIKRKSSLFNVVLMDKTRTHFDIINDICREQNIKEIGFEGNEVSF
                     DLYRSMSNKLSATLKSVDLSTLRETKNEDEIKYIKKACEIVDATFYHIVDFIKVGMTE
                     KQVENEIVRIIKDLGGQKESFDTIVASGLRGALPHGKASEKVIEYGDFVTFDFGAKYN
                     NYCSDITRTICMGTINKELEEIYNIVRKANEECIRVLRPGMTTGEIDKVARDIIGSYG
                     YAGNFGHNLGHGVGIMVHEYPALAPESNEVLKEGMIVTIEPGIYVPSLGGVRIEDDVL
                     ITQDGCMRLTTSTKDLIVVS"
     gene            36674..37852
                     /locus_tag="KNP36_001376"
     CDS             36674..37852
                     /locus_tag="KNP36_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PatB family C-S lyase"
                     /protein_id="HBF0873259.1"
                     /translation="MYNFDDKPDRVSEKCRKWDLNIIRDKFGDIREDFIPMWIADMDF
                     KIPTEIENKFIEAVRRGVFGYTYCYDEFYDSVIGWQKNMHEVNVEKEWITLTYGTVST
                     LHYVVQAFCKKGDSIILNTPVYDPFESSAKKQGVNVICNTLDVVNDRYYINFDKLEVQ
                     IKENKPKLMMFCTPHNPSGRIWTIEEMTRVATICKENNVILVADEVHAEHIHYGTFNS
                     ILKIGKELLENVILLTSPNKGFNLGGLKTSYSIVINKDIRDKFRNKLKQNSITSPNVF
                     GIIGLITAYNECHEWLSGVNEYIKSNYELLETWVNKYNKIKLMKMESSYLAWMDISGL
                     GISASEFTDKLAIDTGVLLEDGSHFVKDGEKYVRINLGTQKENVIEALNRMDLFLKSL
                     "
     gene            complement(38043..39101)
                     /locus_tag="KNP36_001377"
     CDS             complement(38043..39101)
                     /locus_tag="KNP36_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HBF0873260.1"
                     /translation="MNKKKITFIFVILILALILFSFFRSSSQNTKYSKTSYYLGTVNE
                     VTVFNVKESKSDKILNECDSILRYIDNKMSTHIPGSDVSKINDNAGKKFVRVSDDTFF
                     VVKEAIQYSKLSDGYFDITIGPLSNLWAIGTDKAKVPSDSEIQKLLPLIDYKNIILDE
                     KNKSIKLTKENMKIDLGAIAKGYAADKIVAYLKSEDVKKGLVNLGGNIFTLENGKNDK
                     PFKIGIQDPTSKNGESIGNIETTNKSVVTSGIYERFIEKNGKIYHHMLNPFTGYPFEN
                     NLSSVTIISDKSINCDALSTSTFGLGLEKGMNLINKIDNVDAIFITKDKKVYLTKGIK
                     DNFKLTDKSFSIEKLNKQ"
     gene            39168..39539
                     /locus_tag="KNP36_001378"
     CDS             39168..39539
                     /locus_tag="KNP36_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NusG domain II-containing protein"
                     /protein_id="HBF0873261.1"
                     /translation="MKKKDILLILGILVVITACYGIINVINSKNAGNIEIYVDNKLYK
                     TVSINAKEEFKIENRGGYNIVKIHDKGVEIVDASCPDKVCVHTGFINKPSQSIVCIPN
                     RVSIKINTNEKNDNQEDIISK"
     gene            39576..40250
                     /locus_tag="KNP36_001379"
     CDS             39576..40250
                     /locus_tag="KNP36_001379"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HBF0873262.1"
                     /translation="MVNLGNDWDELLKEEFEKDYYLNLRKFLIEEYKTRQIFPNMHNI
                     YEALKHTSYKDTKVLILGQDPYHGDNQAHGLAFSVQPQVKTPPSLLNMYKELKDDLGC
                     FIPNNGYLMPWADQGVLLLNTALTVRAHEANSHKNKGWEIFTDRVISILSEREDPVIF
                     VLWGSNARKKVELIDTSKHYILEAPHPSPLSASKGFFGCKHFSKINEILKKLGKEPIN
                     WQIENI"
     gene            40499..41338
                     /locus_tag="KNP36_001380"
     CDS             40499..41338
                     /locus_tag="KNP36_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HBF0873263.1"
                     /translation="MNFKKLSNAKVSVMAVVLSVGILSGYSALNKQVTLVVRGEERTI
                     STFSSNVGDLLESQNISYDANDIVTLDENTKLSNGDKIEVIDVKEKTVVETKDIPFEV
                     TVVEDGSLLKGDSKVKEEGKSGKSELIYKETYHNGKKVEKEFVKKVVKAEPVNKVVSK
                     GTKVEMQVASSRGESSRRMASSSSSSSSSNNGKNMRVVATAYTGHSITATGTKPKWGT
                     IAVDPKVIPYGTKVYIPQFDMVFTAEDCGGAIKGNKIDIYMNDSKTVYNWGRKTIDIR
                     ILK"
     gene            41582..41678
                     /locus_tag="KNP36_001381"
     tRNA            41582..41678
                     /locus_tag="KNP36_001381"
                     /product="tRNA-Sec"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:41616..41618,aa:Sec,seq:tca)
     gene            41828..42535
                     /locus_tag="KNP36_001382"
     CDS             41828..42535
                     /locus_tag="KNP36_001382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA threonylcarbamoyladenosine dehydratase"
                     /protein_id="HBF0873264.1"
                     /translation="MENNFTTRTSFLVGDDGIEKLNNSNIIVFGVGGVGSFTVEALAR
                     AGVGNITIVDFDDVDITNINRQIPALHSTVGRYKVDVMEERILDINPNINIKKIRSLY
                     NKDTSDEILTERYDYVVDAIDMVSSKIHLIETCEKKGLKIISSMGMGNKLDPTKIVVT
                     DIHKTSTCPLAKVMRKELRDRGIKKLKVVYSTEQPIELKKKVMNGRKVTPGSVSFVPS
                     VGGLIIASVIVNELLGQ"
     gene            complement(42677..43513)
                     /locus_tag="KNP36_001383"
     CDS             complement(42677..43513)
                     /locus_tag="KNP36_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0873265.1"
                     /translation="MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPT
                     NKNILIDGGDEDSENIIISYLRQKRIKTIDIIIATHPDSDHIGSLDNIIKKFNVNSIY
                     MPEQSTDSEAYQNLINSCTDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNS
                     IVFKLTFNDNSFLFMGDAEEENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKIS
                     PDIAAISCGYKNQYGHPHREVINNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEI
                     DT"
     gene            43701..44606
                     /locus_tag="KNP36_001384"
     CDS             43701..44606
                     /locus_tag="KNP36_001384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2156 domain-containing protein"
                     /protein_id="HBF0873266.1"
                     /translation="MFFKDIELNSKKELDPYFDLVDYEACEYCFSTLYMWQHVYKTGY
                     YIGEDFAVLVGEYEGDSFSILPLAKKDKLPEVVDFVLEYFSKNNKKIYLRGITTEVVE
                     FLKEKYPGRFEYIEERDLFDYIYDAESLRTLAGKKNQKKRNHINYFLKEYAGRYEAKL
                     LDKENFDECLVLMKEWESNKEENNEFDESMDDELIGIKKIFNHYDILKDKVKVFGVYV
                     DGKLEAFSIGELLNPNMALIHIEKANPDIRGLYPFINQQFLVSEFKDVEFVNREEDLG
                     IEGLRKAKLSYHPCRFVEKYSVREA"
     gene            44615..45799
                     /locus_tag="KNP36_001385"
     CDS             44615..45799
                     /locus_tag="KNP36_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893611.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0873267.1"
                     /translation="MEIRYAKEEEIESIKEIWSYCFNDTESFMKYYFNDKYKSENTVV
                     ALDEGKIISSLQLNQYKLLLNSKVYNTSYVVGVSTLPEGRGAGYMNKVMKFTLNELYK
                     KGQLVSILMPIDYRLYRRFGYEHCYDQIEYTINTDDLKNFKSSGKMIKSNLSQIDDLI
                     QIDRTFLNEVNGNVLKDEHYYENLFKEIQSEDGFLYIHEGNEKDGYIVYFLQEDKMFV
                     RELFYKNIDALKSMLKFIYNHNTQCKIVTISTPTIDKIRFILDNPKDSDIKIKPFMMG
                     RVINVKKFIEDIDIENDINSSFNLLIEDKFIDENNGLFKISIQNKKVSVEQLDKKGAE
                     KPQEDFDIKLDINTLTQLSFSYIDVNEAIFLNDIKDVSEETLETLNCIFSKKNNYINE
                     YI"
BASE COUNT        17978 a         4991 c         7926 g        14969 t
ORIGIN      
        1 gtaaaaaata tttttaaatt atcatttaat gtaatttaaa tgaattgaag atatatgttt
       61 attgtatgca attgttgtat ttttaggttt tttgtgatta attaaaaaat tataaaaatc
      121 gtttacatgt tgatttttaa aaaaaaaaga tatagaatta tatagaaagt aataaacaaa
      181 aattggattt acgggagtgg aatgaaatga tgaatgttac cttaacagat gtgaaagagg
      241 ctagagagac cattaagaac atagtaaaaa gaactgactt acttgaaagt gttaaactta
      301 gcgaaaaaac aggagcaaat gtgttctata aatgtgagaa tcttcaaaaa acaggttctt
      361 ttaaattaag aggagcttgt aacaaaatag cgagtttaac agatgaagaa aaggcaaatg
      421 gagttatagc ttcaagtgca gggaatcatg ctcaaggagt tgcattggga gcaaaaatga
      481 ctggtataaa atctacaata gtaatgccag caactgcgcc tttagcaaaa gttagtgcaa
      541 ctaaaggtta tggagcagaa gtagttttaa atggtgcggt ttatgatgat gcatatgcaa
      601 aagctgttga aatacaaaaa gaaacaggag caactttctt acatccattc aatgataagt
      661 atgttatagc aggacaagga actatatctc ttgaaatttt cgaacaatta gacaataaag
      721 ttgatactat actatgccca gttggtggag gaggaatcat ctctggtgtt gctgttgcag
      781 caaaagcatt aaatcctaat gtaaaaatag tcggtgttca aactgcaaat ataccttcaa
      841 tgaaagagtc aataaaaaat ggaaaagtaa caacagcatt taatgatact acaatagctg
      901 atggtatagc tgttaaaact ccaggagatt taacttttga aataataaat gaattggttg
      961 atgaaatagt agtggttgaa gagacagaaa ttgcagaatc aatattattt atgatggaaa
     1021 gtcaaaaaat agtttcagaa ggtgctggtg ctgtatgtac agctgctata ttaagtggta
     1081 agtatgtacc agcaaaagat gaaaatgtag tttgtataat atctggtggt aatatagaca
     1141 taaatacgtt atatagaata ataggtgttg ctttagctaa agaaggaaga agatattcat
     1201 ttagtacaat tatggaagat aagccaggaa actttgctga gttaactaga ataataagtg
     1261 agaatggtgg aaacatttta agtgctaatc aaggtaaatt atcagcaggg gaagctctag
     1321 gaaaacaaag tgcggaattt atattagaga caatagatta tgaccatata gctagaataa
     1381 agaaagctat agaagaaaaa ggttttaaaa ttatagaatt ataataaaaa gtgtatataa
     1441 tatacaagaa aaatagtata atagtgtatg aagatacatt ttatgtgtat tagattaacg
     1501 aattaggagg attttaaaat gaaacatgaa gtaatacata ctaatgatgc accagcagct
     1561 ttaggaccat attctcaagc tataaaagct ggaaacttgt tatttgtatc tggacaagtt
     1621 cctcttgtac cagagactat ggaagtagtt gaaggagatg tacaagctca aactgctcaa
     1681 tctttaaaaa atcttaaagc tatattagct gaaagtggag ctgatttttc aaatgtagtt
     1741 aagactacag tatttataaa agatatgaat gaatttgggg ctataaacga agtttatgct
     1801 gaatattttg gagaaaataa accagcaaga gcttgtgtag aagttgctag attaccaaaa
     1861 gacgttaaag ttgaaataga agtaatagct gtattataaa aatacaatat ttttaatttg
     1921 aaaaggctga aaaactatat tctagtgatt cagccttttt ataaaaaaat aaatcacaat
     1981 aaagaacatg ataaatattg tcgaattaaa aaataaaatt aaaataaata ttgcaatatt
     2041 tttgagaagg ttttataatg agtatataat ttgaaacgtg taactattaa attaggcatg
     2101 agttcttgga tatttttatc ctgaggattc atgccttttt tgtattgaaa ttcaaaaatc
     2161 tatttaataa ggaggaagta ctgtgttaaa ttttttcaag aaaaataaaa gctataagtt
     2221 acatgcagta gtgagtggta acagcattaa tattgagaaa gtaaacgatt ctgtgttttc
     2281 aaaaaagtta atgggagatg gagttgcaat tattcctaat agtaatgttg ttgtagcccc
     2341 ttgtaatggt aaagtaactg tgcttacaga atcaaagcat gcctttggta tggtctcaga
     2401 tgagggtgtt gaaatattag tccacatagg aattgataca gttagtttac agggtgaggg
     2461 gtttaaaaat gaagtgtctc aaggagatac tgttaaaaaa ggtagtccaa taataagttt
     2521 tgaaagagaa aaaataaatt ctcagggaat tgattgtaca acaataataa ttgtattaaa
     2581 tcatagcgaa ttttcagaaa taaattgcat ggtagaaaat gaagttgttg cagggcaaga
     2641 tactgttatt gaaattatga aataatagga agggattaat tcaatatgag agtagtaaaa
     2701 atctttaata ataatgcatt atctacagta actaatgata ggaaagaagc tattttacta
     2761 ggtcttggta taggttttaa taaacgtcca ggagataaag ttaatgaaga taaaatagaa
     2821 aagatttatt atgttcaaga ccacatgcaa acaaaatttt tagaattatt aaaaaatgtt
     2881 agtccagaag tgatggatgc ttcacaacaa attataagtc ttataccagg aaatgaggga
     2941 aaatttaata ataaagggat attatcttta gtggaacata ttagttttgc aatagataga
     3001 atgaaaaata atgttttttt acctaattta atgcttttgg atataaagat gatgtattca
     3061 aaagagtttg aattaggagt aaaagcttta gaaattatat atagagtatg tcatatccat
     3121 ttgcctgaag atgaagcagg ttacatagct ttacattttg tcaatttaca atcaaatgat
     3181 aatttggcat atgatacttt aaaatttgta aaaggtagta ttgatttgat taaagaatgt
     3241 tatggattag aattagacga atcgagttta agtacattac gttttagaac tcatcttaaa
     3301 tttcttgctc aaagaatttt taagaatgaa atttgtcagg atgataaaat gattgaaatg
     3361 tatgattatt taattaacaa tcatcctaaa aataaagaat atttagaaaa gttaaatgta
     3421 tatattgaaa aggagtttag gtataaatta gataaacctg aaaaaattta tctactacta
     3481 cacctaacaa aaatcttata agaatgagat gaattagtaa tagaaatata taattttagg
     3541 gggggataag attgaaagaa aaactacttg gaggactgga aacatttgca aaggcaatgg
     3601 ttcagccatt aatgtattta tcgagtgcag gaatattaat ggtggtaggt gtactactta
     3661 caaatgatat gttattagga gtacttccat tttttaaatg ggagccaatt caaatatttg
     3721 gaagcctaat ttataactgt ataatggcta ttattaataa tcttgctgtt atatttgcta
     3781 taggtattcc tgctgcacta gcaaaaaaag agaagcacaa agcagcgtta ataggattta
     3841 tgagttatat aatatacctt acagcttcca acactatgtt aacatcacta ggtcaactag
     3901 caaaagaaag caagatgctt ggactgatag ggactggaca agctactatt ttaggtattc
     3961 aagttgtaga tacaagtgta tttggtggaa ttattttagg gtgtatagct ggatatgtat
     4021 ttaatcgtac aagcaacaaa acatttaaag gagctttaca gatatactcg ggagcaaatt
     4081 ttagttttat atgcatgttc tttgtatcca ttttaattgg agttgtgagt aactttatat
     4141 ggccattagc tcaacaagga atagcttctc ttgcaaatgt catcaaagat acaggtacat
     4201 ttggtttatt cttatatggt tttttagaga gaatattagt accaactgga cttcatcatt
     4261 taatctatac accatttcag ttttctgatt taggaggagt gcttaaagtt ggtgcagata
     4321 cagtttcagg agcctatgct atagttatga cagaaatgaa tttaccagtt gagcgtttct
     4381 cagatagtat atactacatg gcaactggat ttacaaagat gtttggttat ataggtatag
     4441 gagctgcctt tatttatact gcatataagc aaaataagaa gaaagttaag gcaacgatta
     4501 ttccactaat aattacggca gtattagcct ctgtaacaga accattagac tttatgtttg
     4561 tattctgtgc accattttta ttctttgtac atgcagttat agctggtctt tttatagctt
     4621 tattaaaaat atttgatgtt actgcattat gtggagggaa cttattagta tcaattataa
     4681 tgaatactac agtaggcgta gaaaaaacac actggccagt aatgatgata ttaggacttg
     4741 cacaaattat tgtatatttt gtagtattta gttttttaat taagaaattt aattataaaa
     4801 ctccaggtcg tgaagatgag agtacagcta caggcgaaga acaatcaaaa caacttaatt
     4861 tagatgcagg gatagaaaat ataattgatg ggttaggcgg aaaagaaaat attaatacag
     4921 tagaaaattg catcactaga ttacgtgtta atgtaaaaga tgaaagtaag attaatgaag
     4981 atataattaa tttaacgcca aatagcggga ttgtaaggaa aggaaaagat atacaaataa
     5041 tttttggact tcatgtgcat gaggtaagac gtgcagtaga agatttttta gaagcttatt
     5101 aaagatatat atttatatag caagggtaaa taacagcttt aagtgctgtt tactatttat
     5161 taaagataca tataatttat agaggaggaa taattattat gattattact attgttggtg
     5221 gaggaagcac atttactcca ggtattgtta agtcaattgc attaagagaa aaagagttag
     5281 agcttgagga aattcgctta tttgacattg ataaagaacg ccaagataaa gtagctgtag
     5341 ttgtcaactg gatactaaaa gaagatgtta aaacagatgt taaactaact gtaactaatt
     5401 gtgaaaaaga agcgtataca gatgctacat ttatatttgc acaaatgcgt gttggtaaat
     5461 atgaaatgcg tgagcaggat gaaaaaattc cattgaaata tggttgtgta ggtcaagaaa
     5521 cttgtggttg tggagggatg gcatacggac tgcgtacaat acaaccaatg ataaaggtta
     5581 ttgatgatgt agagaaatat gctaaaaaag attattggat attaaattac tctaatcctg
     5641 ctgcaatcgt ttctgaagct tgtcgtaagt taagaccaaa tgcaaggatt ataaatatct
     5701 gtgatatgcc aatagctatt atagatatga tagcggggtc attaaatatc aatgacgttc
     5761 ataatatacg ctatgattat tttggtctaa atcattttgg ctggtttact tcaatagatt
     5821 ataaacatag agacttaatg gaagagatta aggaatacat aaaagaaaat aaaatattat
     5881 taccaaaatc ttatatagaa aacttaaata aaagtcgtag tacaggaaat cgccatgctg
     5941 taagtagctg gatacatgtt tgggaatctg tttatacaat gttagaaagc ttcccaaaat
     6001 atctgccaaa cacttattta acatactatc ttttaagtaa agaaacagtg gaacattcaa
     6061 acataaatcg tactcgtgca aatgaggtta tggaaagccg tgaaaaagac ttatttgaag
     6121 gtgtgagaca ttacttagaa actggagaaa tttctgaaaa agcattttat gcaggttcac
     6181 atggagattg gattagtgat ttggcagttt caattaaaaa tgatacacgt agtcgttttt
     6241 tagttataac tgaaaatcgt ggagctatac caaacatgcc atatgatgca atggtagaaa
     6301 ttccagcata tattggtaaa gatggtccag aagttattgc tcgaggtcca atacctctat
     6361 ttcaacaagg attaatgatg caacaactta acagtgaaaa attgatagta gaagcttata
     6421 tagaaaatag ttatgaaaaa gctttacaag cattcacatt aaataaaact attccaagta
     6481 tgaatgttgc taaagaaatt ttggatgaaa tgatagaagt taataaggaa tactggccag
     6541 aattaagata gtaggataaa ggaaagggtt tttatttaat aattagatat gttttcagag
     6601 tcttttatca aaatgtattc acaaacatat ggcaatatat taaaataaag agtgatattt
     6661 ttagaagaat ggggtgatgc aatgaacatt ataaataaaa ttttttggga agaagatagg
     6721 attggcatga ttacaaataa tttagaggca gatacacata gccactgtat gttacaactg
     6781 ttcttaggga tagaagacag cattgaaata acagtcaatg aaaaattagt taaatgtaat
     6841 tgtatcatag tagataaaaa tatctctcat tcattttcag caagaaaaaa agtttattac
     6901 tctgctatta ttgaacctac atctatatat gcagaacagc ttacctcaaa aatgaatgat
     6961 tttggctact ggatatgtga caatgatgga ttagagaaat tacgtcaaca aggaactttt
     7021 ttgatagata actctagtaa agaacaatat ttaagattta tggaaatgct taataactat
     7081 ttgaatatac ctataactct caaacattat gatgacagaa ttactgaatt gctcaattta
     7141 ttacgtactt gtaattgtga taatcatact atttcaagtt ttgcagataa agtgtcccta
     7201 tcagcaagta gattatcaca tctgtttaaa gaacaaatag ggataccttt aaaaagctat
     7261 atcttatttc atcaaatgga gtgtgctttt agagaattac tttctgggaa aaatgttacc
     7321 gaagcttcta tgactgctgg attcgatact ccatcacact ttgcagggac agttaagcga
     7381 atgatgggaa tgcctgtttc tttatctttg aaagatagcg aatttttgaa agtatattaa
     7441 atattctcgt tatataatga agttgtacta agaaaggggc tttgttatga ataaagaata
     7501 tttagaggaa acaaaaatgt taaattataa tgaaccacaa cttaagcttt tggtatcatc
     7561 aaagaattgg ttggaattag atgattttca taaaataaaa tctatttatg agtttgtaca
     7621 gaatgatatt ttatttggat ataatgcttc tgatatgtta agcgcaacac aggtattaaa
     7681 tgatggtatg ggacaatgca atacaaaagc tactctttta atggcattat tacgtgcagt
     7741 gaatatccct tgtaggcttc atgcttttga tgtaacaaaa gattttcaac gaggagctac
     7801 atccaaattg atttcactat tagcaccaaa atatattctt catacttggg tagaggtatt
     7861 ttatcaagat aggtggattg ctcttgaggg tgtcataact gataaaaaat atttagaagc
     7921 aattcagaag aaatttttta atcatggtgg aacatttaaa aagtatgcaa tagctacaaa
     7981 tgatttgaaa aatacatcta ttgattggga tggtaaagat acttttatcc aaaaagaagc
     8041 tatcgtgtat gattatggta tttttccatc accagacgta tttttttcta ctcattcaca
     8101 acatatgtca aaattaaaaa atttcatata tgtacatctt atcagaaaaa taatgacaaa
     8161 aaatgtatgt aaggctagaa acaattatat tgataaaaac gaatgagtgt ttaagaggta
     8221 actatatagg aaatatatag aataattaaa actgtactgg ttaaaatgaa taaaaaggag
     8281 ttatcacaga gcaaacttaa attgttcata ggataactcc ttttctgtat taacttctaa
     8341 taatttgatg tctttttata aaacatatag atacaattaa accagtaaat gcaagagtag
     8401 ctgctattga aaatgcaaca tctattccat gaatgttaga cagcatgttt gaactcatat
     8461 gagctttctt agtagcactt gtcattatag taataagtat agcagaacct atagctccag
     8521 atatctgacg gagtgtgtta ttaattgctg tggcatgaga tataagttct ctatctaatg
     8581 ttttaattcc ccatgtagtt aatggcatta aaaccattga aataccaatc atacgaatac
     8641 aatacatcaa tgacacatga attaaagatg tatctctgcc taaaaaagcg aaggataaag
     8701 ttcctaaaaa caaacatcct gttcctaata ttgatagagc atgaggtcca tatttatcta
     8761 aatgacgtcc tgcaattgga ttgagtacaa ccatcaatat agcaccaggt aacattaatg
     8821 aacctgaaga taatgcagaa aatcctctta cagattgaac gtacagagga atcattaatg
     8881 tagcagacat cattgaggca tatacaatca taattaatat tgtagaaata agaaatggtt
     8941 tatttttaaa aaccctcaat tctaaaaaag gttctttaga ttttaattga cgcaatgtaa
     9001 ataaaattaa tgacataatt cctattaata ttggtaaata tgtggcaata ttagtccacc
     9061 cataattacc ttgattagta aatccaatta ataaaccacc aaaacctaga gatgatagta
     9121 ctattgaagg tatatctaat tttagttttt gagtttcccc aacatttctt aatagaataa
     9181 atgatagtat aacatctaat atagcaatag gggaaagaaa cagaaataaa ctatgccaac
     9241 caaatgaatc tactaaccat cctgataaag ttggacctat tgctggagca aatcctactg
     9301 taataccaac taaactcata gctgcaccac gtttttcctc agggcataaa tagagtataa
     9361 taacttgtaa aagtggcatt agagaaccag aacccattgc ctgcaacaca cgagcaatca
     9421 acatagttga aaaattatta gaaaaaagtg caataataca tcctatagaa aagatagaca
     9481 ttgatgtaat aaataacttt ctagtactaa atcgatttat taaataagct gttgtgggta
     9541 caataatacc tgcaataagt agataaattg ttgttaacca ctgaccaata tcagcagtaa
     9601 ttttaaaatc tgacattata ttaggtaatg ctgttgacaa tagtgtttga ctgagagaac
     9661 ttataaaagc accagtcatt acaattgcta ttattaaatt tcctttttta ttgttacttt
     9721 gggtttccat aatttataac gtctcctttt ttaattgatt tttaatgctg ttcaataaaa
     9781 gtacttttgg tcttaaagtg tcttcttttt ctaaatatgc aatcattgca tccataatta
     9841 aagaatcata ttgttgattt tttccttcga cgtataattt ttttattgct tctagtaatt
     9901 taggattttc aaggagagaa gtatcagttt tgattagttc ttctatatct tgtatcgttt
     9961 taaaaaatag cgatttatta tgaagggaaa agtaaacttc atcttcttgt ttatgtaaaa
    10021 acattgattt ttcaattaaa ggatttagat tatccatatt ttctacaact aaatctagaa
    10081 tttgtatagt aaatttggca ataaagtata catttatttc tcttttttgt acatgaataa
    10141 tgtatataaa ctgatgaatt agagcatcca ataagaaaac taaatcaaat ataatttttt
    10201 ctattttatc accatagtta tcaaataagc ttagtttgta ttcattcaat aagttagctc
    10261 ttgattttgt ttgcaattta cttgtagcct tacgttgctc ttcagaaaag ttttctctta
    10321 tataggtatt tatggtagtt ctagaaaaaa tatttttcca tacagcaatt atctttctgt
    10381 ttaacttttc tgatgatgga atgtcattat tttcatttat ggaatgtata atttctaaaa
    10441 acttttcatc ataataattg attatttcgc agataaaact ttccttagtt tcaaaatgct
    10501 tgtaaaaagt agctttagac attttacact cttttacaac atccgatatt gaagtatttt
    10561 gaaaaccttt ttggtcaaaa attttttgtg caatagttat aatgagcctt tgtttttctg
    10621 tcactttatt atctcctttc acgcaaaaac gtttagtact atatagtacc tacaagtttt
    10681 gataaatata ttatacatca tttggaaaaa aaatcaatat atagactgta atatgaaatt
    10741 tttgaaaaat ttgttgttat ttttagtcgt ataaaaaaga aacttaagag tttcttaaga
    10801 attgtttaaa gaagttgcaa taaattagtg gtatgattat agtatgaaag agaatgtctt
    10861 gaaatttttc tgtatcaaat tccaattatg gaggtgtagt atatgaaaaa gaaaatttgt
    10921 gtagcaataa tttttgctct atttatagtt tttgtagaaa tgtttattga tagctctagc
    10981 gaaggaagta aaattatgac agctgaatta agtaaataca ggaaaggcgt aaatgtatta
    11041 tcaataaaca atattatagt agcgaataaa aaatatagtt tgcccaaaga ttattctcct
    11101 caggaaagca gtgaagcgag agatgctttt tataaaatga ataaagatgc tcaaaagtca
    11161 ggattaaatt taaaagcttt tagtacatat agaagttatg aatatcaaga tagattattt
    11221 aagtcatatg taaaagaaca tggagaaaaa gaagcaaata gattttcagc taaacctgga
    11281 gagagtgagc atcaaactgg acttgctttt gatattggag gagatgacca gtcttgttgg
    11341 gcaaataaaa agttcaacaa tacaaaagaa gctaagtggt tgtatgaaaa tgcatataaa
    11401 tatggtttta tacttagata tccagaaggt aaagagaata taacaggata tatgtatgaa
    11461 tcttggcact atagatatgt tggaactgaa catagcaaaa actttgcaat gaataatttg
    11521 actttagaag aatatttaca tataaattaa gagatggttt gttaaaatta ggttaaaata
    11581 aaaaataacc tagactatta gctgtgtaaa gtgatataat gtaaatacaa tttaagataa
    11641 ctactcgaag gggagtagct tacacgaaag tggtaattaa tcgtcaagac agtagaaata
    11701 ctcggttaat tagcaaggga ttccttgata gcaagacctt caaaataagc attaggtatg
    11761 tttgttttgg ggtctttttt tattcaagga atttttattt aaaaaaattt aaatttcaag
    11821 tatacataag agcccccaaa cataaaataa atttattgaa gaggagggca acaaatgtct
    11881 tacaaaagta cttatcaaga agtaattaaa aatttagact caagtttatc tggtttgagt
    11941 aaagaaagag cagaagagtt gttagaaaaa aatggagcta atgaattaaa agaagcagat
    12001 aaggttccta cttataagct tttcctagaa agttttaaag acccattagt aataattcta
    12061 ttgatagctg ctttagtaca aatattttta ggtgaaacag tggagtctat aataattttt
    12121 gcagttatta ttataaactc tgttctgggt gttgtacaaa caaaaaaagc agaaagttca
    12181 ttagaaagtt tgaaaaattt atctgcacca aacgcaaagg taataagaga caataaaaaa
    12241 atgacaattc cagcaaaaaa tctagtagtt ggagatattg tattcttaga agctggcgat
    12301 tacataccag cagatggaag gcttatagaa gcacaatctc tcaaggttgt agaagggatg
    12361 ttaactggag aatcagaacc agttttaaag catatagaaa aaataagtga agatgtaagt
    12421 ttaggtgacc agaaaaatat ggtatttagt ggtgctgtag ttgtttatgg tagaggttct
    12481 tttgtagtga ctggaacagg tatgaatact gagatgggta aaatagctgg gcttttagaa
    12541 agtgctgaaa ataaacttac accattgcaa caaaaaatag aggattttag taaaaaactt
    12601 ggtgtaggta ttgtaatact tgctctttta atatttataa ttcaagtagc aagaaattac
    12661 tttatggctg gaaatggaga aatgacacaa attattttag attcattcat gttctctgta
    12721 gcagtagcag tagcagctat accagaagct ctatcatcaa tagtcactat agtattggct
    12781 gttggaacaa atagtatggc aaaaaaacaa gccataataa gaaaattacc agcagtagaa
    12841 actttaggtt caacaagtgt aatatgtact gataaaacag gtactcttac acaaaataaa
    12901 atgacagtag ttgattatta tatgtatgga actaataatg atgagttaga taaagaaaaa
    12961 gtaaactatt cttatcatgc taaattattg actatggttt ctacattgtg taatgactct
    13021 catataacta gtgatggtaa agaagttggt gacccaacag aagtggcttt aataaattat
    13081 tcaagtaaaa atgatttaga ttatgataaa ttaagaagta agtatatcag aataaatgaa
    13141 ataccatttg actcagacag aaagcttatg tctactgtaa atagtatata tggagattat
    13201 ataatgttta caaaaggtgc tccagatatt gtgtttagta gatgtaaata tgctttgaaa
    13261 aatggttcaa aagtagatat aacagatgag ataatagaag aatataaaca taaaaatgaa
    13321 gagttctcaa atagagcact tagagtatta gcttttgcaa taaaagatgt cccagaagaa
    13381 gattttatac cttcaattga tgacgaacat gacatgacat tggttggaat aatggcaatg
    13441 atagacccac caagagaaga agtaatggat gcagtaaaag aggcaaagag tgctggtata
    13501 aaaactgtta tgataactgg tgaccataaa acaacagcag cagcaattgc aaaagagatt
    13561 ggtataatgg aagaaggaga cttggctctt actggaaaag agcttgatgc tttgagtgaa
    13621 gaacaactat atgaaaaact agaaaatata agtgtatatg ccagagtctc gccggaaaat
    13681 aaaattcgta tagtaaaagc atggcaacat aagaataata taacagcaat gactggtgat
    13741 ggtgttaatg atgcacctgc attaaaacaa gcagatatag gaatcggtat gggaagtggt
    13801 actgatgtag caaaagatgc ttctgctatg gtattggttg atgataactt tgcaagtata
    13861 gtaaatgctg ttgaagttgg tagaacagta tacagtaata taataaaatc aattacttat
    13921 ctatttgcag gaaacttagg agctatagta tccatagtat ttgcagtgtt tgcaggttgg
    13981 tcaaatccat ttacagcttt acaacttttg tttataaact tagtaaatga ctctttacca
    14041 gcaattgcat tagggtttga aaagtcagaa aaaaatataa tgaataaacc tcctagacac
    14101 ccggatgaaa gtatactagc aggaggaaca ttgaaggcag ttgctataag aggttgtata
    14161 ataggtgtag ttacaataat tgcacaatat ataggattac aagtatctcc agaacttgga
    14221 gtagcaatgg cattttcaac attgatatta gctagaataa tgcaaacatt acctgcacgt
    14281 tctaataatc aaacagtaat aaaattaggt tttttcagca ataaatacgt tataggagca
    14341 gttttagtct gtcttgggct ttactcttta acactaatac cagtgctaag aggaatattc
    14401 tctataccaa caacgtttgg attgtaccag ttggggattt gcctagggtt agcattaatt
    14461 tcatcaatat taatggaact taacaaatta ataaatagaa gtgaagtaaa ataatcaaaa
    14521 aattaaaggg catattgatt ttaacaatat gccttttata aatagtctaa tttattctat
    14581 attatcgatt atttggaatg cttttataac ttcaggtaat tctttttctt caggcattct
    14641 aaatcttata aaatttttat caagtccagt aaaatcactt ccagatataa ctcttatttt
    14701 taatttagca aactcttgtt gtaaatctat gtccttgttt ttatgttcaa ctgtcataat
    14761 tgatacagta tcactagttt cagctatatt aaggtttttc catggaatta ataattgatt
    14821 ttttatatct tttgtttttt cttttaattc ttctataaat tgaacatcat ctaataaatt
    14881 tgctgcaata ctacgagata tttcagacac ttcgtaagga gtagaaatct ttttaatagg
    14941 gctaacaagt tgttctggaa gaactgcata tcctgctctt agtcctgcta aaccaaatcc
    15001 ttttgaaaat gtttttaaag caattacatt atcataatta tttagaagct tgacagctga
    15061 attttctttt ggcatgtatt caccataagc ttcatctacc ataactgcta tatcatattt
    15121 agctgcttcc cttactatat tttcaattga tgataaaggt ataatttgtc ctgtaggatt
    15181 gtttggattg tctatgtaaa ttactttata ttctggattt attttttcaa taaattcttt
    15241 ttcattaaac ttgaaattat cctctttctt taaaagaaca taatcataag ttgcaccatg
    15301 catttttata tctgtctcat attctgagaa ctgaggtgaa tatcctaaaa ctttatctcc
    15361 cttttcaata aatagtctat ttaaaaggta aataacatgt atagaaccat ctgccaaaca
    15421 aattctgtca gtatctaatg ctataaaatc tttccaataa tcgactatat tatcttttaa
    15481 agcaattgaa tgaggatatc ctcttatcat atcaaatttt aaagcattaa aagcttctac
    15541 agctttgttt gagtaagaca cggtatttat accttcacca cagtctatct cgaatacatc
    15601 ttctgaatgt ccagattcta ttgcataact ttttttcaac tgcatttcaa tagctttgtt
    15661 aatttttagt ttcatacttt atcactcctt atttagtcaa taataaatgt tataaaagtt
    15721 gctagattta aaatattatg aaaatatata atagtaaaaa tgaatataaa tattataata
    15781 gctcacttta tttaatatga ttatatatca tatattgtaa aatttctagc attataagac
    15841 tataaattga aaatattcag aaaaatacta caagaaacga tttattttgc tcttaaaata
    15901 agttaaatga atgttattaa ttttgtaaat tgaaatagtt taagtataaa gttatgatat
    15961 aatctaataa gggtaattct ttagattata ttaaggaaat ataggtatac aataaaaagt
    16021 tatggagttg gattatggga tataaattaa ttgtaacaga tatggatgga actttattag
    16081 gcaataatca taaagttaca gatgaaaata aaactgcact acaaaaagtt ataaaaagcg
    16141 gtattaatgt aactttagca acaggaagag ccttcgattc agctaaatgc aatgtagatt
    16201 ttcttaaaga ggacatgcca ataatagctt gtaatggttc attaataaga gagcaaaatg
    16261 gaaatataat atattcaaat aagattgata caagaacatg tttaaacatt ttagatgtat
    16321 tagataaata cgatatttac taccaatgta atagtataga ttctatgctt tcgaaaaaaa
    16381 tagaaggacg tgaagataga ttaagtgtat ttttaggctc tgaaacagaa gtaattgtaa
    16441 aagatgattt gagagaagaa atctttaaaa aagatatact aaaatttgta atcatagaag
    16501 aaaaaaatcc atctattttg gatgaaataa gaaaagaatt gagaaaagtt caaggaataa
    16561 agataacctc ttcatggcca aacaatattg aagtcatgaa tgaaggtgtt gataaaggta
    16621 atgcagttaa aattttagct gaaaaaatga atatagacag agaagatata attgcatttg
    16681 gagacaatta caatgacata gaaatgataa agtttgctgg tcttggggta gctatgggaa
    16741 atgcagaaga attgattaaa caagaagctg attatgttac agatacaaat caagacagtg
    16801 gagttgcaaa ggcaatttat aaattcctag agttaaaaga atcacttagc tcttaaaaca
    16861 gtatataata ggaaaaaata ggttgactat tttgtagata gtaattataa tacaaataga
    16921 taaaatataa aaatttagat tcagtgaaaa agagagtaga tatagagaaa atctcagcga
    16981 attgggggat ggtgtgagcc taatgataac actttatatt gaaaagaact ttggagaata
    17041 ctacttgaaa ttcagtatgg tagtaggtaa tctcgcctta agagaataga gtgggtaaac
    17101 attgtttacc aactagagtg gtaacacgga atatttcgtc tcttggtctt tttgaccaag
    17161 agatttttta gtttcattga gttacaagac ttataattaa aatacaaaaa attaaaatat
    17221 gaggtgaaag ttatgaaatt atggggtgga cgctttagaa aagcggaaaa tcaacttatg
    17281 gaagaattta ataaatcttt tggctatgat tgtgtactgt acaaaaaaga tatcgaagga
    17341 agtgtagcac atgttcatat gcaagtaaaa tgtggacttt taacagaaga agaaggaaag
    17401 tctataacag aaggtttaaa agggatactt gaagatgtag aaaatggaaa gttagtattg
    17461 gatggagagt atgaagatat acatagtttt actgagataa atttaattca aagaattgga
    17521 gatgttggca agaagcttca tacagcacgt agtagaaatg accaagttgc agttgatatg
    17581 agattgtatg ctaaagaaaa agcaaatgat ttggtggatt taatatctga atttaaagct
    17641 actataaaag atgttgctga caaaaaccca gtgatgatgc caggctatac tcatcttcaa
    17701 agggcacaag tagtgacatt taagcatcac ttaatggcat attatagtat gtttgataga
    17761 gatgagaaaa gaataaaaaa tgctatagaa atattagatg aatcaccttt aggctgtgga
    17821 gctttagcag gaactacgca tgatatagat agaagtataa cttgtgaaca attaggattt
    17881 aaaaaagtag tagataattt tatggatgga gtaagtgata gagattattt actagagcta
    17941 atgagtgatt tttcaattat aatgatgcac ttaagtagat taagtgaaga gttgatactt
    18001 tggagttctc aagaatttgg atttgttgag atagatgatt tatatacaac tggaagtagt
    18061 ataatgcctc agaagaaaaa tccagatggt gcagagctta taagaggtaa gactggtaga
    18121 gtatatggaa acttatttgg tctttttaca gtaatgaaag gaataccatt agcatataat
    18181 aaagacatgc aagaagataa agaaggtttt ttcgatagtg tacatactct tgaaatgtgt
    18241 atacaaataa tggatagaat gatagccaca ctaaaggtaa atgaggataa aatgaaacaa
    18301 gcagtaaaaa atggtttttt aaatgcaaca gaagttgcgg attatttggt taaaaataat
    18361 gttgctttta gagatgcaca tggtatagta ggaagtatcg ttatatattg tgaagataat
    18421 aaaaaagcaa tagaagattt aacattagaa gaattacaaa agttttcaga tgcttttaag
    18481 gaagatattt atgattttat cgactatgag agtatattaa ataagggaat aaaaaagaat
    18541 ttaaaataat gtatttattt ttaaaagctg taaatttgaa tgttatcatt taaatttaca
    18601 gctttttatt gtgtaagatt ttattatata aaagtaagaa acttaaaagg agtagtattt
    18661 aaaataaata caaataaaaa attattatta aaatgataat taatatcaat aagtattgac
    18721 aaaattattt ctaaatacta ttatatataa tataaataat aatgaaaatc aatatcaaat
    18781 aaatgggagg aaatctaatg aacttattag tgattggtgg tcatgaaaga atggaaaaag
    18841 attatatggt tatggccaag aaaaaaggtt ataagacaaa ggtatatact accatgtcat
    18901 ctaaattaaa taattctata ggaaaaccag atgcagttgt catacttaca tcaactgttt
    18961 cacataagat gtctagaacg gttgagtctc aagctaaaaa acaagatata ttaatcgtaa
    19021 ggcataaaaa tagtagtaag gtagcattta atgaatgtct agatatggtt gatgaatgtc
    19081 tgggaaattg ttcaaaatgt aagcttaaag acaaacaaaa acaaaaaaat atataggtat
    19141 aaaaaataca taaacataaa attaaaagta ctgagataat agttataatt attatctcag
    19201 tacttttaga tttataagga taagtatagt ataaattttt tattataatt tccaactact
    19261 tgttactttt tcatattttt tttacttcta gctttttttc tttttttctt ctttatattt
    19321 gaagctatta taaataaaac taaaagcact agaatacctg caataatctt aacaaaagtc
    19381 attaaaacat tattttcagt caaaaatgga agactgctat caagattatt ttttgcaatt
    19441 aagtctatac tgttttctag tttaccatta ttatatacat ttaaagtacc aaccttagct
    19501 ccttttttta taggcaaatc aattttattt aactctgttt tggtatcata attgccttga
    19561 gattcatctt tttctaagaa tatcctataa ctattttttg gttcataaat caattcatgt
    19621 tgttttgtaa acaatacttt tttagtatct gtgtattttt ctttatcaac aatagtagca
    19681 cacttaaagt tatcaaatcc ataatcaatc agaatacgtg agtctaaata taaatcagca
    19741 ttagttgaat taaatacagc aacgataact cttctgccat cttttacagc actcgataaa
    19801 agacatttac cagcagcatc agtatatcca gtttttatac catcaactat atcatatttt
    19861 atatttatag gttgaccttt gtatgtaatc ttatcatgtg atgtcaaaaa cttattagtg
    19921 tttacaaagt atctctcata aggatatgct tttgtagctt caaatttaag tgacttagtt
    19981 tttacaattt gtctaaaagt atcattattc atagcttctc tagctatgag agccatatca
    20041 tgagctgttg tgtagtgatt tgggtctggt aatccatgag gattattaaa atgagtatta
    20101 gtagctccaa ttttttttgc ctcagagttc atgaggtcaa taaatttttg tacattgcca
    20161 ccaccaacat atctagctaa tacaaaagca gcatcattag cagaatgaac caaaagagca
    20221 tctagtaact gctttacagt aaaagattcc ccatttttta gatacatact agagccatct
    20281 atttgaggta aatctttaat ttctattact tgatttaaat ctttaacctc ctttagaact
    20341 aaacaagctg tccatacttt agttgttgaa gctggataaa gcttagaatt tccatcctta
    20401 ttatatagta ttttgccaga ctcatagtcc attaaaactg catgtttagc aactatagct
    20461 ggttcattat ctgcaaaaga gatattagag cttcctaaaa atgaagtaaa tatcaataaa
    20521 cagattaata aaagtgataa atttcttttc attgtgagcc tccaaatttt aaattcatct
    20581 tttagtatag catatatttg tcaataatta aaagaaagga gtgattaata tatgaaaaaa
    20641 aaggtaaaat ttatttcgtt ttttgtttta tttattttaa taatatcatc aataatcgtt
    20701 tataaatcgc ttattttcaa agatgatatt tatgttgtaa gtaaaaaaaa tttacctaat
    20761 gaaaaaacac atgttgtaga gaatgaaatt aaaggtgaag ataataatca cagtaaagta
    20821 actaaagaca tagataaaaa ttttcaaaat aataaaataa ctatatacat aagtggagca
    20881 gtaaatagac ctggaattgt aactatagag tcagacaaga gactttatga tgctgtagaa
    20941 ttactaggag gaacgacaaa agaagcagat ttaaatggag tcaatctatc agtaagatta
    21001 gaagatgaac aacattacat aatacctaaa ataggtgaag caacatctgt tacaagtaat
    21061 gatgattcca ataaactaaa tcagaagaat gagtcaagag gtgagcctaa aaataaatcc
    21121 aataaaaata tatctaacga atcaaaagta aatataaatg tagcgacgat agaagagttg
    21181 gattctctac ctggggttgg agaagctaca gccaataaaa ttttacaaca cagagaagaa
    21241 aatggacagt ttagttcaat tgaggaaata aaaaatgtaa atggtattgg agataaaaag
    21301 tatgaaaata taaaagattt aatttgtgta gactaaaata taatacaaaa cttacatata
    21361 gatatgttat tataaatatg tatgtatatg tgtgtacatg tggaaattta gtaaaggagg
    21421 cacttttatg aaaaaagaac aaaaaaaact tacagagatg acaacagcag gtggttgagc
    21481 cgctaaaata gggccagagg ttctggcatc agttttatct caattgccta aaaatgataa
    21541 tatagaaaat ttattagtag gactagatac agcagatgat gctgcagttt ataaattaaa
    21601 tgatgatatg gcacttatcc aaactttaga cttctttaca ccaatggtag atgacccata
    21661 cgtatttggt caaattgctg catcaaattc actatcagat gtatatgcta tgggaggcaa
    21721 acctttggtt gctatgaata ttgtttgttt tccatcatgc catgatatgg atgtacttgc
    21781 agaaatatta aaaggtgggt ttgataaagt gaaagaaagt ggagcacttt tggttggagg
    21841 gcatactgta gatgacaaag agcctaaata tggtctttca gtttctggga ttgtaagtcc
    21901 aaataaagtt ttatcaaatg ctactgcaaa acctggtgat aagttaatta taacaaaacc
    21961 aattggagtg ggtgtattaa atacagccat gaaagaaggt atggtagaac aacatatagc
    22021 agataaagta atagaaataa tgatacattt aaataaatat gcagcaatga gttttgagaa
    22081 atttgatgta aattcggtta cagatataac tggttttggt ctacttggtc atactttaga
    22141 aatggccaaa gcttctgaag taagtattga aattgaatca aaacatgtac caattattga
    22201 aggtgcaata gaaatggcac aaatgggaat tatacctgct ggtatgtata aaaatatgca
    22261 ttatgtatct aaagatgtag aagttgtagg aaatatagaa gttgcagttc aagatatttt
    22321 atacgaccca caaacatcag gagggttgtt aatttcagta aaagaagaac ttgcagagga
    22381 gcttgtaaaa gatatgaaat taaatggagc aatagaagct aaaattatag gttctgtagt
    22441 tccaaaaggg gaaaaatata ttacagtttt ataaaatatt atagagaaag agtgattgtt
    22501 ttgagcaaaa gagaattgtt tgcaatgttg ccttcagttg atgaagtatt aagtgataat
    22561 agaattgtag aaataataaa tgaatatcct agaagtttag ttttagaatc tgtgagagaa
    22621 gtaatagatt taaaaagaca atttatatta agattaaaag aagatgcatc aaactctgta
    22681 acaatagagt ttggtgaaat aatagaatct gcaatagaga gagttaagtt aaattactca
    22741 ttatctttaa aaaaagttat aaatgcaact ggtacagtta ttcatacaaa tttaggaagg
    22801 tctttactta gtgaagatat aaaagatgaa ttatggtgtg ctgcttcaag gtattcaaac
    22861 ttagaatacg atttggataa tggagaaaga ggttcaagat actctcattt aactagtaca
    22921 ataaaaagac ttactggagc agaagatgta ctagttgtaa ataataatgc agcggcagta
    22981 cttcttgtac ttagcacaat ggctaaagga ggagaagcaa ttgtatctcg tggagaatta
    23041 gttgaagtag gtggttcatt taggattcca agtataatgg ctcttagtgg tgcagaatta
    23101 gttgaagttg gttcaactaa taaaactcat ttgaaagatt acaaggaggc cattacagaa
    23161 gatacaaatg tattgatgaa ggttcataca agtaattata gaataatggg attcacagag
    23221 agtgtttcta tagaagaatt ggttaattta ggtaaaaaat ataaactacc tgtaatagaa
    23281 gacttaggaa gtggagtttt tatagattta tcaaaatatg gtttatctta tgaaccaact
    23341 gtattggatt ctattcgaca aggtgcagat gtagtaactt ttagtggaga taagatgctt
    23401 ggaggtccgc aagcaggtat tatagttggg aaaaaagagt atatagaaaa aatgaagaaa
    23461 aatcaactta ctagagcact tagagttgat aagcttacaa tatgtgctct tgaagcaaca
    23521 ttgagaatgt atttagatga gacaaaagct atagaaaata tacctacttt aaaaatgttg
    23581 acatataaaa ttgaagaatt agaagtaaaa gcaaataaac tatttgaaaa aataactgct
    23641 ttaaacttaa atgcaaacat aaatatagaa gatggatttt cacaggtggg aggagggtct
    23701 atgcctcttg aaactataag tacaaaggta atatcaataa ctcctgaaca tatgaatgtt
    23761 tcatctttag aaaaaaaact aagacttagt gaagcacata taatagccag agtgtatgat
    23821 aataaatatg tactagatgt aagaactata tttgatgatg aatttgatgt aatagttgag
    23881 gaattgagaa aagcatttaa ttaaataaat ttgagttaat aaatattaaa tttagaagta
    23941 taagtatgaa gttttgatta aaaaatagct acacacactt gtgactttag tcatagcagg
    24001 tttagagggg gcaaaaaatg aaaaatgtag taattggaac agcaggtcat attgaccacg
    24061 gaaaaactac tcttataaaa gcattgactg gaagagagac tgatacgtta gatgaagaaa
    24121 aaaagagagg tatttcaata aacttaggat ttacttattt tgatttacca aacaatagaa
    24181 gagctggaat tgttgatgtc ccaggacacg aaaaatttat aaaaaacatg ttagctggag
    24241 catcaggaat tgatatagtt ttacttgttg tagcagcaga tgaaggggtt atgccacaga
    24301 cagttgagca tttagatatt ctaagctttt taaatatcaa aaatggaata gtggttctaa
    24361 ctaagtctga tactgtagat gatgaattta gagagctagt aaaagaagat atttgtgaaa
    24421 aaataaaagg aacttttctt gaagatgctg aaataattga agttgattct atatctaaaa
    24481 gaggtataga cactcttatt gaaaaaatag ataaaatgag tgatgatata gaagataaaa
    24541 atgaaaactc tccagcaaga cttaatatag acagagtatt ttcaataaaa gggtttggta
    24601 ctgtaataac aggcacttta atagaaggaa agataagtat agaagatgat ttggttatat
    24661 atccacaggt attaaaaaca aaaataagaa gtatacaagt tcatggagaa aataaagata
    24721 cagcttatgc aggtcaaaga acagcaatca atatatcaaa tgtaaaagtg gatgatataa
    24781 aaagaggaga tgttttagct gcaccaaact cattggagga atcaatgatg ttagatgtaa
    24841 aattatcatt ggtaaatcat ttagataaag gattaaagca ctgggataga ttaagattgt
    24901 atcatggaac tagagagata ctttgtagag cagttccact agataaagaa ttaattgaaa
    24961 gtggagaaag tggctatgtt cagttgagac ttgaagaaag catagtatct aagaaaggtg
    25021 atacgtttgt agtgagacgt tattctccaa tggaaactat aggtggaggt gtaataattg
    25081 acccatctcc taaaaaacat aagaaatttg atgaaaaagt tatagaagca ttaaaaataa
    25141 aagaaaaagg cgaactaaaa gatataatag aagagtactt aaaaaggaat ttaaaaaatt
    25201 atccaaatat aaaagaaata atgagctata gtggtgctca tgaagaagat gtaaaaagag
    25261 cgcttgaaac acttatatca gaagataaag tatttattat aggaaatatg tatatgcata
    25321 taaatcaata caataaatta aaagaaaata caataaagct tttaagtgag taccataaga
    25381 agtataggct tagaaaaggg atactaaaag aagaagtaag gtctaagata gagagtaatt
    25441 ttaagactag ggagatggat attttattag aaaaattgtc tacagaaaat gctataaaaa
    25501 tagaaaataa tatagtatct ctattagatt ttgaggttat tttaaatgat aagcaaaaag
    25561 aaatagcaaa aaaaatagaa aaaagattaa aatcatgtgg agtttcttct atactgacaa
    25621 tagatgaagt ttctgaagga aatcataact atgctgaagt attggagtca atgataggta
    25681 ataaagtaga gaaattagat gatttgtata taatggacaa agatatttat gaaaatgcaa
    25741 agaacatttt gataaattat ataaaagaaa ataaagaaat aacattagga gaatacagag
    25801 atttgattga ttctagcaga aagaattgca tgattatatt ggaaaacttc gatagaaaca
    25861 aaataactaa aagagtagaa aacaaaagaa ttttgtttta gcagaaaatg tctgtttttg
    25921 ctttaaggta taaagaagga attataatgt cgagtatcgt ataattaatt agtataaaat
    25981 attaattaag aggaagtgta aagtattgaa gaatataata cctgatgtaa aaccagatat
    26041 aaaagaaaga gaagacatga gccttttatt tataataatg ggctcagtac ttttattatt
    26101 tattataaaa gatatagaga aatatgaaac tttattacat gccatatata cgatattttt
    26161 agtagctaca ggagtaatta tatttaatac tacaaaattt aaagtagatt cattttctac
    26221 atttttagga ttaattttta tagctactgg agtattggag tgtatatatt tatttaattc
    26281 cttggggatt aaaactaagt ctataatgga gattaacatc acaatatcag caataacaga
    26341 tttatttcct atactgggtg tatacttaag ttttaaattt gttaaggata acaaacaaat
    26401 ttattcaagt gtaattttat ttatagcaac tgctacatta acaataacat ctttattcat
    26461 aatatcagga atttgtgact atctgggaaa tggtaaatca caatatgctt taggagttat
    26521 aatatctata ttcataataa ttatttctat cattagtgga attgaattaa attcaagttc
    26581 aaataaaggt aaatgggaat atgatgaaaa aaagattttt aacagaataa tagtaataat
    26641 aatcttatca agagttccaa atctattgca tatagttatt gataatagaa atgtagagag
    26701 gatattatca caaataataa taaatgtagc cttatattat ttatataatt acatagtatc
    26761 taagaatatt aagaaaacag cactggaatt gcatgatacg aatgaagaat taacaaaaaa
    26821 aacggaaagt ttaaaagaaa agaataaaaa attaatctat gagacagaaa agatagagga
    26881 acttaaggga atacttatga aaagagaatc taggctacaa tctacattag atgtagcagt
    26941 aaatagcata gtagtattta gcaaagatgg agaaattaca tatgcaaata agagctttag
    27001 aaatactttt ggagactata aagaacaaga taaattgact gataaaataa aaaacttcaa
    27061 tgatttgata gaaagcattc attatgtgtt tgttcatgag aagaatgcag agaaacttat
    27121 tagtacaagc gataataaag tttatcaagc tatatttgca cctttaatta ttgcttcaca
    27181 aacagaagga gtattgtgtg tactagaaga taagactaag aaaaaggagt acgaacgcaa
    27241 acttattgaa gcaaataaga gaagtaaaga ttttttagaa agtattggag atggcatagt
    27301 agtgcttgaa ggtaataaca aaatatatgt taataatgca tgtagggaaa tttttaaaaa
    27361 taatttagag agtattgatt tttcattagt atgtaaaagt gaagaaagta tagaaaaaag
    27421 atatgtaata gatggtgaag taaagtatgt agagatgagt ttttctcagt atactaatgc
    27481 tggtactaat aaaactatta ttgtaatacg tgatacaacc tctcgaaaaa tatctcaaat
    27541 aaaacttgag gaaagtcaat catcatattc aagatttata gatatattac ctgatggcat
    27601 atgcttatta aaagaagatt taagtataaa ctatgcaaat aagtcgtttt tagatatgct
    27661 agcttttaca aacatagatg atataaaaga ttctaatatt aaactattaa tgaatgcgaa
    27721 tactgaagaa aaaatgaaat ttacggataa tatggctaaa gttttaaatg aaaatagaag
    27781 tatactttta ctggaacatg aattgataaa tagttatgat gatatagtag aagtagaatt
    27841 aagtgcatta ccttttgcta tatacaatac tagatacata atgcttatta taaaagattt
    27901 agtacataag aaatattccg agcaagcaga aaaagaactg cttgaaagat ttaaaacaga
    27961 taaaatcaaa acggagtttt ttgcaaatat gtctcatgaa ctaaaaactc cactaaatgt
    28021 tatatctagt tcaaatcaac tggtagattc tttctataga aatgaaaaga taaaagatta
    28081 caataacaat attaaatctc atgtggattt agttagacaa agttcttata ggcttcaaag
    28141 attaataaat aacattatag atttaacaaa gatggagtct gggttctata cactaaaact
    28201 tgcgaaatac aatattgtat ctgtaataga agacttattt atgaatatag aagagtatgc
    28261 acttagaaaa gacataaaaa ttctttttga tacagacctt gaagaaatta atgtttatat
    28321 agacaaggtt gaaattgaga gaattatgtt gaatctattg tcaaactgta ttaagtttac
    28381 tgataatgga ggctggatat atgtaagtat tcattataaa atagataaag taatcataag
    28441 tgtaaaagac actggagttg gaataccaca agataaatta gagttgattt ttgaagaatt
    28501 ttcacaagtt gataagactt tatccagaaa tactgaagga agtggaatag ggcttgctat
    28561 agttaagaat ctagtaagtc ttcatggtgg agatatagaa gtagtaagtg aagtgaataa
    28621 aggcacagag ttcttaattt cacttccaat gaagggattt agtagtgaac attacacaga
    28681 agataagaga atatataata ttcaagaaaa aataaaaata gaattttctg atatatatta
    28741 ttaaaaatga ttatgagcaa aaataaaata aaaatactat ttgtttaaat atttaagttg
    28801 taagaaatag gctatcataa ggtaaattat tatgatagcc tatttttagc taggttttat
    28861 atctatatgt gagaacatat aatctctaaa ttaccttcaa aactaaaatc tccaaagtcg
    28921 tttggcagta taaaatgcat accctttttt aaattatatt ctacagaatt gtgtataagt
    28981 tttccatttc catccaacac actgtataaa gaaaaaggtg tattgtgtgt aaaattacat
    29041 tttccaaaaa catctaattt ataaacacta aaaaattcgt ttgacacaaa tgttgtgcat
    29101 ttaaagtctg atgttgatac gattttatag tcagtatcga aatttatatg aggaacattc
    29161 gtaacatcta ttgatttttg aacatgaagt tcacgcttat tacctgaatt gtcagttcta
    29221 tcataatcat agactctata agtagtatct gagttttgtt gagtttctaa aatcaatgtt
    29281 cctttgcata tagcatgtat agtgccactt ggaacataga aaaagtctcc cttttttata
    29341 ttaacctttc taagtagttt gtcccattca ttattattta ccatatttac aaattcttta
    29401 tgagattttg cattatgacc tattataatt tctgcatcat cagaacaatc tattacatac
    29461 caacactctg tcttacctaa ctctccattt tcattttttt tagcatattc atcatttgga
    29521 tgaacttgaa ctgataaatt atcatttgca tccaatattt ttgtaagtaa aggaaactta
    29581 tcaccaggtg tgtttccaaa taattctcta tttttattcc acaattcaga tagtttttta
    29641 cctttatatt ttccattttc tattaagcaa tctccatttt tatgagagct tatagcccaa
    29701 cattcaccag ttgttggcga atctatttca taattaaatt tatctttaag tgcagtacca
    29761 ccccatattc tatccataaa aataggtttt aaaaataatg gttccataat cctgttcctc
    29821 ctatgatatt aaatttatcc tacaaataat tatatataaa tagattataa aatcaatagt
    29881 aaaaaagttt tgtcccttga aatgacataa agtataagga gttattaaat aagataaact
    29941 atgatatata atataaagtt ctaaattgga gtgataatta tggagttgtt taaggcagaa
    30001 agcaaaaaat ataaaaaaga atttttaaaa ttattggagc aatgggttag tataccttca
    30061 ttttatgata gaaaaactgt atctaaagac atgccttttg gaaaaggagt atatgatgca
    30121 ttaaactggt ttgaaaatct aggtagagaa aacaatttca aagtaaaaaa tatagataat
    30181 catgctgttc aaattgaata tggaaatggt aaagagtatg tagatatatt tggacattgt
    30241 gatgttgtaa atccaggtga aggatgggat agtgaaccat ttaaactaaa tattataggt
    30301 gataaattag ttgctagagg tgtatctgat aataaagggc ctatgatagt gaatttttta
    30361 gcactaaaaa tgataaagga tttagatatt aatttaaaaa gaaaggttag attaatagct
    30421 gggggaaatg aagagagtgg atttaaatgt ataaagcatt attatagcaa agagccatat
    30481 ggtgtatgtg gatttactcc agatgctaaa tttcctgtat taaatggaga aaaaggtgga
    30541 gcaataataa agttaatttc aaatatagac gataaatctt tatatataag tggtggaata
    30601 gagtttaata caataccaga taaagtttat ataaagaatg tagaaaaatt gggtaaagat
    30661 aatatatgtt ttgatattaa caatatatcg ataaattatg ataatggcaa ttatattgtg
    30721 tatggaaaag gtggtcattc atctaaaccc gaaaaatcaa taaatcctat attagctaca
    30781 attaaacttt tgtcagaaaa tattgatgaa aaatggacaa aagatttata taagttgata
    30841 aatcaagata atataaatgg aaacttattt ggtttaaata ttgaggggaa atgtggaatt
    30901 ttatcaatgg tgccaacaat aataaatata gtagatggaa aattagaagt agttttaagc
    30961 gttagatatc cagaaatatt aaccattgaa gatataataa aaaaatttaa tttgtatatg
    31021 gagcaaaata atattaataa atttgagctt attggggaaa atttaaagca agcaaattat
    31081 atagatagaa attcaaaact tgtaagaagt ttgcatgata tatatataaa gtattctgga
    31141 gatttaaaaa atgatgttag agtaactagt gcaggaagtt atgcttctga aatgaataat
    31201 tcagtaatat ttggttgtga atttcctgat ggtagctttg gcaatgtcca tagtgcgaat
    31261 gaatttgcta gcttagatag atttataact gcaataggta tatatgcaga ggcaataatt
    31321 acattatgta ataaaatata aatacaaaat gtcccttata tagacatatt atatatacaa
    31381 ttaaaatttt acttgatata taattgaaat caaagagaag gtgatacaat gataactaag
    31441 aaacatgcaa taatagtaaa gagtttaagc aataaagatg gatatatgac atcaaacgaa
    31501 ttagctatca aattggatgt gtctactaaa actattaaaa gatatatagc agatttaaat
    31561 agtgttttaa gcaaatatga tttggtaata gcttcttcta gaggtatagg atacaagtta
    31621 agcggttcta aaaacaatat agccagagct gttaaagaag caaataaata tattgatggt
    31681 tttttagatg actctgaaga gtcaagaatg tcaaatataa tatgtatgct tattaataga
    31741 aattatatga gtatagaagc aatggcagaa gaattaaatc taagtatagc cgctataaat
    31801 aaattgtcta gtaagcttaa aagaaaactt gaaaagtatg acttagttat aaaatctaaa
    31861 ccttactatg gaagctatat acatggtgaa gaaattaata taaggcaatt aattactgac
    31921 tatgcaataa aattagatga aaaaagtaaa gtgaaggtgt ttttagatga cattagtgaa
    31981 aacgatatac actgtataga aagtatttta gaaaagcact taagagaaaa agatacaata
    32041 atttcagata aagattttaa tcttttgctt tcaaaaataa tcgtttctgt atttaggagt
    32101 aagagaggtc atagtaacaa tataaactta atggatacaa gttatagatt tcataactac
    32161 tactttatag aaaatctaat gaaagaaata tctgataaaa ttggatttaa acttattgaa
    32221 gatgaagtaa tttatatttc aaattattct ggtgtaatag cctataaagg tacacaagga
    32281 agaaaaaaca caagtgaaat tgaggaacga ataagtagtg ttataagtag tgcacttcaa
    32341 gatatattcc ttatttcagg tagtgattat acaaaagatg atgagtttat ggttgcaatc
    32401 tctgaccata taaagagatt tttaaataga gctagagcta atgtaaaatc aaataatcct
    32461 ttacttcatc aaataaaaga gaagtttcct atagctttta atttagccgt gtttttatca
    32521 aataaactag aaactgagtt taatttaaaa cttgatgaag atgagcttgg atatatagct
    32581 atccactttg ctgcttcaaa tgaaagaatg aaaaaaaata ctagtaagaa aatttgtata
    32641 gtttgtcatt atgggatagg aacaggacaa cttatttctg aaaagctaaa acagaatata
    32701 agtgatttaa gtgttgtagg tgtttatcca gttagatatc tcgatatggc tataagtcaa
    32761 gatgttgatt tgatagtatc taccgttgaa ttaaaaggat atgaaaaacc tgtcttatat
    32821 atagaaaata tatttgatga tagcttaatt gaaaacgtaa acaaagcctt ttatgaaaag
    32881 gaagaaagaa gaaagataat aagcaacatg tttgatgaaa aagctttttt cagtataaag
    32941 gctaatacta aagaagaggt cataatttca ctttcaaata aactaaaaga aagagatttt
    33001 atagaggaaa gttctataaa aagtataata gatagagaaa atatttcatc aactgaaata
    33061 ggaaatctag tagcaatacc ccacacaata gtgaagggag ataaaaaatc tataatagga
    33121 gttggaatac ttgaaaatcc aataatttgg gataagcaag aggttcagct agtatttatg
    33181 gtatttttta atactaaaga aaaacataat ttctcgatat ttaaatacct ttataatttt
    33241 ataaaagatg aaggcggagt aagaggaatt attaaaatat gtgactttaa taaattaatg
    33301 gcactgatag gtaattaagg aggaaattaa taatgggaac aaacatattt aacaaagaat
    33361 atgtattttt aaatgttgat gctaagtcaa aggttgaagt tttaaaattt atatcaaaaa
    33421 aagctaaaga cttaaacttg gcagaagatg agagcttagt atatgaaggt ttaatggcta
    33481 gagaagaaca atttactaca aatttaggag aatctatagc aatacctcac actaaaaatg
    33541 atgcaattga aaatccagca gtagtagtat tgaagtttaa tgaagatgtt gtttggaatg
    33601 aaggtgagga taaggttaaa ttagcaataa gcttacttat gccaggaaaa agtaaagaga
    33661 atattcatct taaattatta tcatctcttt caagaaaatt aataaataaa gaatttaaag
    33721 attctctttt aaaaagtgat aatgttgaag aaatatctaa cttaataaat gaagctttag
    33781 gtttataatt aaacactaag gttataaaat aaaaaaataa ttaactaaaa ataggaggaa
    33841 tttgaaatga ataaaaaatt agtagcatta tgtgcttgtc caatgggact agctcacact
    33901 ttcatggcag cagaagcaat agagcaagca gcaaaggcat taggttatga agcaaaagtt
    33961 gaaactcaag gtgctgatgg tgtacaaaat gagttaacaa gagatgatat attaggagca
    34021 actatgataa tacatgcagt agcaataaca ccagaaggta tggaaagatt tgatggttgt
    34081 gaagtttatg aagttgaatt acaagaagct ataaaaaatg cagaaggtgt tataaaagaa
    34141 atagaagaag atttaggaat ataataaatt tattgtggag gaaatagaat ggcaattaag
    34201 aaaaaagtta taaacagttc aggtgcttct acaacaggag gaaataatgt aggaaaatct
    34261 actccatcta gtccaactca atcaaaggga aatggaaaat ggaaagaaat aagtaaacat
    34321 ataatgacag gtatatcata tatgatacca gttttagtaa tgggtggact tataggggcc
    34381 ttatctcaat taataccata tgctatatta ggacttgacc catctgtagg tatagttgat
    34441 gctatgaact caggagaatt tacagggttc aagcttagtc ttttaaatat agcacaatta
    34501 atgtcaaatt tcggatttac tttgtttgga tttgcgatac cactgtttgc agcattttgt
    34561 gcaaactcta taggtggaaa aacagcttta attgcaggat ttataggtgg atatatagct
    34621 aataaacctg taggtgtacc acaattcgtt gatggacaat ggactgaagt tgttccagtt
    34681 gcatcaggat ttttaggtgc aatactaata gcatttataa taggatattt tgtaaaatgg
    34741 ttaaataaat ctataaaagt ttctcataac tggttagctt ttaaaacaac atttttaata
    34801 ccattaatag cgtcattagc ttgtatggta ttgatgatat ttataataac tccatttggt
    34861 ggattaatta atgaaagtat gaaaaacttc ttaacagcag caggagcagc tggagaatat
    34921 gtatatgcaa cagctttggc agcagctaca gcattcgact taggaggacc aataaataaa
    34981 gcagcaggat tcgttgcact tggtttaact acagagaatg tacttccaat aacagcaaga
    35041 acaatagcta tagttgttcc tccaattgga ttagggttaa caacattatt agataaaaga
    35101 ttagtaggaa gaagagtata tgatagacaa ttctatcaag caggaaaaac ttctatattc
    35161 ttatcattta tgggtatatc tgaaggagca ataccatttg cacttgagag accaggtttt
    35221 gttatacctt taaacatagt tggaagtgta ataggagcta ttacaggtat aattctagga
    35281 gcaattcaat ggttcccaga gtcagctata tgggcatggc ctctagtaga taacttattt
    35341 ggatatataa taggtatagc agttggtgct atattcatag cagtaggaaa tatattctat
    35401 agaaataaat taataaaaga tggtaaactt gttgtagatt atatcgacta gtatttaatt
    35461 tttactatct ataaataact ttggctggta atatggtttt aatcaatatt accagcctta
    35521 cctatatgat taattaaagg cggtggagat aagatatgga taagatagaa aaagtaagag
    35581 agtattttag agaatatgat atagatggat ttcttataaa tagtcctaca aacaagtttt
    35641 atgttggaaa tttatttagc tcttcaggtt atgtttttat aacgaaagaa tcacaatata
    35701 taatagtaga ttttagatat tttgaagaaa ttaaaagaaa atctagtttg tttaatgtag
    35761 tattaatgga caaaactaga actcattttg atataattaa tgatatttgt agagagcaga
    35821 atataaagga aattggattt gagggaaatg aagtatcttt tgatttatat agaagtatga
    35881 gtaataagtt aagtgcaacc ttaaaatcag ttgatttatc tacattaagg gaaacaaaaa
    35941 atgaagacga aataaaatat ataaaaaaag cttgtgaaat agttgatgct acattttatc
    36001 atatagtaga ctttataaag gttggtatga ctgaaaagca agttgaaaat gaaattgtta
    36061 gaattataaa agatttaggt ggtcaaaaag aatctttcga tacaatagtt gcatctgggc
    36121 ttagaggagc attacctcat ggaaaagcaa gtgaaaaagt tatagagtat ggagattttg
    36181 ttacctttga ctttggtgct aagtataata attattgttc agatattacc agaaccattt
    36241 gtatgggtac tataaataaa gagttagaag aaatatataa tatagtaaga aaagctaatg
    36301 aagagtgtat aagggtttta agaccgggaa tgactactgg agagatagat aaagttgcaa
    36361 gagacataat tggttcatat ggatatgctg gtaattttgg tcataatctg ggtcatggtg
    36421 taggaattat ggttcatgaa tatcctgcat tagctcctga atcaaatgaa gtattaaaag
    36481 aaggaatgat tgtaactata gagcctggta tatatgttcc aagtcttgga ggcgtaagaa
    36541 tagaagatga tgtacttata acacaagatg gatgtatgag attgactaca tctactaagg
    36601 atttaatagt tgtaagctaa aaataaatta gataaatatt ttataacaat aagaaaagaa
    36661 gaggtaaatt taaatgtata attttgatga taaaccagat agagtaagtg aaaagtgtag
    36721 aaaatgggat ttaaatatta taagagataa atttggagat attagagaag attttatacc
    36781 aatgtggatt gctgatatgg attttaaaat accaacagaa atagaaaaca aatttattga
    36841 agctgtaaga agaggtgtat ttggatatac atactgttat gatgaatttt atgattcagt
    36901 tattggttgg caaaaaaata tgcatgaggt aaatgtagaa aaagaatgga ttacattaac
    36961 ttatggaact gtatcaacac ttcattatgt agtacaagct ttttgtaaga aaggtgatag
    37021 tataatatta aatacaccag tttatgaccc ctttgaatca tcagcaaaaa aacaaggtgt
    37081 aaatgtaatt tgtaatacat tagatgttgt aaatgataga tattatataa attttgataa
    37141 attagaagtt caaattaaag aaaataagcc taaattaatg atgttttgta caccacataa
    37201 tccatctgga aggatatgga caattgaaga aatgacaagg gtagcaacta tatgtaaaga
    37261 aaataatgtt attttggttg cagatgaagt acatgcagag catattcatt atggtacatt
    37321 taattcaata cttaagattg gaaaagagct tttagaaaat gttattctat tgacatcacc
    37381 aaataaagga tttaatcttg gtggattaaa gacttcttat tcaatagtta taaataagga
    37441 tataagggac aaatttagaa ataaattaaa gcaaaattct ataacttctc caaatgtgtt
    37501 tggaataata ggattgataa ccgcttataa tgaatgtcat gagtggttaa gtggtgtaaa
    37561 tgaatatata aaatcaaatt atgaactttt agaaacttgg gtaaataaat ataataagat
    37621 aaaattgatg aaaatggaat catcttactt agcttggatg gatataagtg gattaggtat
    37681 tagtgcaagt gagtttacag ataaattggc tatagataca ggagtattat tagaagatgg
    37741 gagtcatttt gtaaaagatg gtgagaagta tgttagaata aatttaggaa ctcaaaagga
    37801 aaatgtaatt gaagctttaa atagaatgga tttattttta aagtctttat aaaaatttgg
    37861 ttgaattagt attttatata aatttaaact attaatatgg tatatacata agtagaattt
    37921 gttttagatt acttaagtat ataccatatt ttatataaaa attaaatttg cattagtcat
    37981 gtgataacta tttaaattca tatgtatttt gtatgtataa tagatataat tattatttaa
    38041 acttattgtt tatttaattt ttcaatagaa aaagatttat ctgtaagttt aaaattatct
    38101 tttataccct tagttaagta tactttctta tccttagtta tgaatatagc atctacatta
    38161 tcaattttat taattaaatt catacctttt tcaagaccaa gaccaaatgt agaagtggat
    38221 aaggcatcac aattaataga tttatcagag attattgtaa cactacttaa attgttttca
    38281 aaaggatacc ctgtaaatgg atttaacata tgatgatata tttttccgtt tttttcgata
    38341 aatctttcat aaattccaga agtaacaaca gacttatttg tagtttctat gtttcctatg
    38401 gattcaccat ttttactagt tgggtcttga atacctattt taaaaggttt atcattttta
    38461 ccattttcta aagtaaatat atttcctcct aagtttacta aacctttttt tacgtcctct
    38521 gattttaaat aggctacaat tttatcagca gcatatcctt tagctatggc acctaaatca
    38581 attttcatat tttctttggt taattttata gatttatttt tttcatccaa tatgatgttc
    38641 ttataatcaa taagaggcag aagtttttgt atctcagaat cacttggaac tttagcttta
    38701 tctgttccaa tagcccataa atttgataat ggaccaattg ttatgtcaaa atatccatct
    38761 gataatttgg aatattgtat agcttctttt acgacgaaaa atgtatcatc agaaactctg
    38821 acaaattttt taccagcatt atcatttatt ttagaaacat cacttcctgg tatatgagtg
    38881 ctcattttgt tgtcaatata tcttaaaatt gaatcacatt catttaagat tttatcactt
    38941 ttggattctt ttacattaaa tacagtaact tcgtttactg taccaaggta gtagctagtt
    39001 ttactatatt tagtattctg gcttgaactc ctaaaaaatg aaaataaaat taatgctaaa
    39061 atcaatatca caaaaataaa tgtgattttt ttcttattca tggtatattc ctcctatgaa
    39121 attgtgttat tattttatta taacataatt tcataggagg acaaaaaatg aagaaaaaag
    39181 acattcttct tattttaggc attttggttg ttattacagc atgttatggg ataataaatg
    39241 ttataaattc taaaaatgct ggaaatattg agatttatgt agataataaa ttgtataaaa
    39301 ctgtttcaat aaatgccaaa gaagaattta aaatagagaa tagagggggg tataacatag
    39361 taaagattca tgataaaggg gttgagatag tagatgcttc atgtcctgat aaggtttgcg
    39421 tacatactgg atttataaac aagccaagtc aaagcatagt ttgtatacct aatagagtga
    39481 gcataaaaat aaatacaaat gaaaagaatg ataatcaaga agatataatt tctaaataaa
    39541 ataataaaaa taattgaaag gaattggtga taattatggt taacttagga aacgattggg
    39601 atgaattatt gaaagaagaa tttgaaaaag attactactt aaacttaaga aaatttctta
    39661 tagaagaata taaaacacgc caaattttcc caaatatgca caatatatat gaagctttaa
    39721 aacacacttc atacaaagac acaaaagtct taatattagg acaagaccct tatcatggag
    39781 ataatcaagc tcatggttta gctttttcag ttcaaccaca agtgaaaact ccaccatctt
    39841 tattaaatat gtataaagaa ttaaaagatg atttaggttg ttttatacct aataatggat
    39901 atttaatgcc ttgggcagac caaggagtgt tacttttaaa tactgctctt actgttagag
    39961 cgcatgaagc taattctcat aagaacaaag gatgggaaat tttcactgat agagtaatat
    40021 ctattttaag tgagcgtgaa gacccagtta tttttgtact atggggaagt aatgcacgta
    40081 aaaaagtaga gttgattgat acaagtaaac attatatttt ggaagcacct catccaagcc
    40141 cattgtcagc aagtaaaggc ttttttggat gtaaacactt ctctaagata aatgaaattt
    40201 tgaaaaagct aggaaaagaa cctattaatt ggcagataga aaatatataa aagtaaaagg
    40261 taacaaaatg ataacaaaac aacaataaac aatgacattg ttgtaactaa tagaaatatg
    40321 cttaaatagt tgaaaatact atgtatgcat atttctattt ttttgtcaag ttgacaactc
    40381 ttgaaaaaat agttacaatt tagttacaca aaaaacacaa ataaaaaaag aaacttacaa
    40441 agcagaattt tatgaagcaa aatatatagt gtaaaaaatc ttagggagga aattttatat
    40501 gaattttaaa aaattgagta atgctaaagt ctcggtaatg gcagttgttt tatcagttgg
    40561 aatattatcg ggatactctg cgcttaataa acaagtaaca ttagtagtaa ggggagaaga
    40621 aagaactata tcaacattta gttctaatgt aggagacctt ttagaatctc aaaacattag
    40681 ctatgatgca aatgatatag taactttaga tgaaaataca aagttatcta atggagataa
    40741 aatagaagta attgatgtaa aggaaaaaac agttgtagaa actaaagaca ttccatttga
    40801 agttacagtt gttgaagatg gctctttatt aaagggtgat tctaaggtta aagaagaagg
    40861 aaagtctggt aaaagtgaat taatatataa agaaacttat cacaatggaa agaaagtaga
    40921 aaaggaattt gtgaaaaagg ttgttaaagc tgagccagta aataaggttg taagcaaagg
    40981 gacaaaggta gaaatgcaag tagcctcatc aaggggagaa agttcaagaa gaatggcttc
    41041 atcatcatct agtagcagta gtagtaacaa tggtaaaaat atgagagtgg tagcaactgc
    41101 atatactggt cacagtataa ctgcaacagg aacaaaacct aagtggggaa caatagctgt
    41161 agaccctaag gttataccat atggaactaa agtttatata cctcaatttg acatggtgtt
    41221 tactgcagaa gactgtggtg gagcaataaa aggaaataaa attgatatct acatgaatga
    41281 ttcaaaaaca gtttataact ggggaagaaa aactatagat atacgtatat taaaatagtt
    41341 aaataattta tatttttact ggaaattata ttttgattat atagagaaga aactctttat
    41401 agattctaaa aatataattt ccagtttttt attttggata tgtaataaaa caggtaaatt
    41461 ttaaccatgt atagataaaa gctatttaaa ttataattta ctatcatata aatctataaa
    41521 aattgttgca aagagtcaaa atatatgata ttatagattt cgttgagaag gatttcatta
    41581 tgggagtgga tgggtgccgg tgtgccctct agtcttcaaa actagtatga ggggttaaga
    41641 gcctcttagg tgggttcgat tcccacgcat tcccgccaat atgtaaaagg tatcttttaa
    41701 ttaaaagata cctttttaaa tttgttttaa gataatttag ttttaatgat atataatatt
    41761 ttgtattata taatgtaaat tttataatac tattattgtt cagataaaag tctaggagag
    41821 tgaaaagatg gaaaataatt ttacaacgag aactagtttt ctagttggag atgatgggat
    41881 agaaaaactt aataattcaa atataatagt atttggagtt ggaggagttg gtagttttac
    41941 tgttgaagct ttagcaagag ctggagtagg caatattact attgtagatt ttgatgatgt
    42001 agatataacc aatataaata gacaaatacc agccctacat tcaactgtag gaagatacaa
    42061 agttgatgtc atggaagaaa gaatattaga tataaatcct aatatcaata taaaaaaaat
    42121 aagaagtctt tataataaag atactagtga cgaaatacta actgaaagat atgattatgt
    42181 tgtggatgcg atagacatgg taagttccaa aatacatcta attgaaactt gtgaaaaaaa
    42241 aggattgaaa ataataagtt ctatgggtat gggaaataaa ttagacccaa ctaaaatagt
    42301 cgttacagat atacacaaaa caagtacttg tcctctagct aaagttatga ggaaagaact
    42361 tagggataga ggtatcaaaa agttaaaagt agtatattct actgaacaac caatagaact
    42421 taagaagaaa gtaatgaatg gtagaaaagt aacacctggt agtgtatcat ttgtcccatc
    42481 tgtaggaggt ttaataatcg catctgtaat agtaaatgaa ctattaggac aataagtttt
    42541 aaatatttta atttataaat tttatataca aatttgaagg ctagaaggat gaatataaag
    42601 caattttata ttcatacttt tagcctagtt attttatatt accttatttt atgtagttgt
    42661 agctttattt tttagattat gtatctattt cataattata ttttgtaaat ataatttctc
    42721 catcactata aaaaacaata tctcctattc tgtctgttct ataaattgat acatggtttt
    42781 gttttagatt attaataacc tccctatgtg gatgaccata ttgattttta tatccacatg
    42841 atattgcagc tatatctgga ctaatttttt ttataaattc taaagatgaa gaagaattac
    42901 ttccatgatg acctattttt ataaaattaa tattatttaa tttaaaagaa tgtaaaattt
    42961 ctttttcatt ttcttcttca gcatcaccca taaataaaaa agaattatca ttaaaagtta
    43021 atttgaaaac tatagaattt aaattagatt cttcttgtat atatgatgga cttaatacat
    43081 atatatttat attgttatct atgtttaaaa catcattttt atagagatgc tgaatagata
    43141 agtttttatc cgtacaagaa tttattagat tttgataagc ctcactatca gttgattgtt
    43201 caggcatata tatggagttt acattaaatt tttttataat attatcaaga cttcctatgt
    43261 ggtctgaatc tggatgagtt gctattataa tatcaatagt ttttattctt ttttgtctaa
    43321 gataactaat aattatattt tcgctatctt catcacctcc atcaattaat atattcttat
    43381 ttgtgggtgt ttgaactaaa atactatcac cttgtccaac atcaatcata tgtatagata
    43441 gtagagattt tttgtcacag ccgattaaaa gtgatattat aataagtatt gataaaaaaa
    43501 ttttatttct caataaaaaa tcactccatt cattacatgt ttatataaat ttatgatggg
    43561 taatataaga tatatatgac ttattatatt ttatatttta aacaatataa atgaaattaa
    43621 taccataata aaattggagt tttttatata tacaaaataa aatttttaaa attaagcaat
    43681 aaaaaaggta ggaggatttt atgtttttca aagatattga actaaattca aaaaaagagt
    43741 tagacccata ttttgattta gtagattatg aagcttgtga gtactgtttt agtactttat
    43801 atatgtggca acatgtttat aagacaggat attatatagg tgaagatttt gccgttttag
    43861 ttggggaata cgaaggagat agcttctcaa tattaccact tgctaaaaaa gataaacttc
    43921 cagaagttgt agattttgtc cttgaatatt tttctaaaaa taataaaaaa atatacttaa
    43981 gaggtattac tactgaagta gtagagtttt taaaagaaaa atatccaggt agatttgagt
    44041 atatagaaga aagagattta tttgactata tttatgatgc agaaagttta agaactctag
    44101 ctggtaaaaa gaatcaaaag aagagaaacc atataaacta tttcttaaaa gagtatgcag
    44161 gtagatatga agctaaatta ttagataaag aaaactttga tgagtgttta gtactaatga
    44221 aggaatggga aagtaataag gaagaaaata atgaatttga tgaaagtatg gatgatgaat
    44281 taataggtat caaaaagata tttaaccatt atgacatatt aaaagataag gtaaaagtgt
    44341 ttggtgttta tgtagatgga aaattagaag cttttagtat aggagagctt ttaaatccaa
    44401 atatggcatt gattcatata gaaaaagcta atcctgatat aagaggtctg tatccattta
    44461 taaatcaaca atttttggta agtgaattta aggacgttga gtttgtaaat agagaagaag
    44521 atttaggtat tgaaggatta agaaaagcta aactttctta tcatccttgc agatttgttg
    44581 aaaagtacag tgttagggag gcttaataga ctatatggag attaggtatg ctaaagaaga
    44641 agagatagaa agtataaaag agatttggag ttattgtttt aacgatacgg agagttttat
    44701 gaagtactat tttaatgata aatataaatc tgaaaatact gtagtagctt tagatgaagg
    44761 aaaaattatt tcttctcttc agctaaatca gtataagtta ttactaaata gcaaggtata
    44821 taatacatca tatgtagtag gagtttctac acttccagag ggaagaggag ctggatatat
    44881 gaacaaagta atgaaattta ctttaaacga attgtataaa aaagggcaat tagtttctat
    44941 attgatgcct attgactata gactttatag aagatttgga tatgagcatt gttacgacca
    45001 gattgaatat actattaaca cagatgattt aaaaaatttt aagtcaagtg gaaaaatgat
    45061 aaagtctaat ttatcacaaa ttgatgattt gatacaaata gatagaactt ttttaaatga
    45121 ggttaatggt aatgtgttaa aagatgaaca ttattatgaa aacttattta aagagattca
    45181 aagtgaagat ggatttttat acattcatga aggaaatgaa aaagatggat atatagttta
    45241 ttttcttcag gaagataaaa tgtttgtcag agagttattt tataaaaata tagatgccct
    45301 taaatcaatg cttaaattta tatataatca caatactcaa tgtaagatag ttactatatc
    45361 tactcctaca atagataaga taagatttat attagacaac cctaaagata gtgatataaa
    45421 aataaaacct tttatgatgg gaagagttat aaatgtaaag aagtttattg aagatataga
    45481 tattgagaat gatattaata gctcatttaa tttattaata gaagacaagt ttatagatga
    45541 aaataatggt ctatttaaaa tttctataca gaataagaag gtatctgtag agcagttaga
    45601 taaaaaaggt gcagaaaagc ctcaagaaga ttttgatatt aaattagata taaatacctt
    45661 aacacagtta tcattttctt atatagatgt aaatgaagct attttcttaa atgatataaa
    45721 agatgtttca gaagaaacac tagaaacact taattgtatt ttttctaaaa aaaataacta
    45781 tataaatgaa tatatatagg tagagtacgt taaaagattt taaaaatctt ttgacgtatt
    45841 tttttgttta gataacaatt tatc
//
LOCUS       DAEHWM010000024        44022 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.025, whole genome shotgun sequence.
ACCESSION   DAEHWM010000024 DAEHWM010000000
VERSION     DAEHWM010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 44022)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44022)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44022
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.025"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(88..699)
                     /locus_tag="KNP36_001386"
     CDS             complement(88..699)
                     /locus_tag="KNP36_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0873268.1"
                     /translation="MKMVKKLILSTIMALVLVLTIGCSNAEEKVKSNFEANLAALEMY
                     KYDEKGISDALTEAEYKQIQTYNSKDKVSMIAQLTPLYGKENAEKIYETIVKLIQGVE
                     KTVTVESSSKDKITLKVVSKALDTSKVMSEANTLVKSYVTDEKNYDKKEKEVQDDMTK
                     MIIDLYNKKPTKEVTTMITYTKKDGKWQPPSNIQKLCEGIYTI"
     gene            complement(791..1780)
                     /locus_tag="KNP36_001387"
     CDS             complement(791..1780)
                     /locus_tag="KNP36_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="HBF0873269.1"
                     /translation="MLLLKKDDIKKVFTMRDAIEADKEAFRIYCEGKSVNPLRTNISV
                     PSQDASMLFMPGYVEELGCGGIKIVSVFPKNAQKGKPVIPATVLLLDGETGEVSAVLD
                     GTYVTQIRTGAASGAAIDVLAKKDSKIGALIGLGGQGEPQLEAMIEARNLDEVRVFSR
                     NKESREKFAEEMNLKLSKYNTKIVAVESSDEAIDNADVIVLATPSKQPVLNGNLVKKG
                     ALISAVGSYMPDMQELCPNCLTRASKIFFESTDAVLSESGDILIPLKEGKISKDDFSG
                     DLGNVINGTIPGREDDDEIIVFKTVGIGVQDVVTAKRIYDKAKENGIGIDWKW"
     gene            complement(1847..2710)
                     /locus_tag="KNP36_001388"
     CDS             complement(1847..2710)
                     /locus_tag="KNP36_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 and DUF4163 domain-containing protein"
                     /protein_id="HBF0873270.1"
                     /translation="MKFFKVDTKAKVLRYVFVLTLTIMAVLAIKHDYKYNNLRKDASI
                     NLNSNKEAVTVMSNQSLPKGNTNSKQTLSVSTIGSKTIVKNDEYLESTINMPVITNSN
                     KIVERSTNDKIKNDIFEFYNKSYKEAKQYLKDNPDEKNKFVANVDFELKKNTDSALSI
                     KVRYYTYSGGAHGFYQDIAYNVDMRTGKFLELMDLFKDNTKYKEVIDEEIKRQIAELE
                     KKDEENIGIYNFKGIKENQNFYLQDENLVVYFDLYDITPYAAGIPEFSINKALISSML
                     KPEYVDLFDLK"
     gene            complement(2816..3412)
                     /locus_tag="KNP36_001389"
     CDS             complement(2816..3412)
                     /locus_tag="KNP36_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheB"
                     /protein_id="HBF0873271.1"
                     /translation="MERFNNMVIAIGASVGGTEAILEIIKDLPKSTPGIVVVQHMPAI
                     FTYMYAQRLDKQCIMNVREAKNNDRVEQGNVLIAPGGYQMKLCTDKQGYYVTCEKGER
                     ISGHCPSVDVLFDSVAEVAGKNSIGIILTGMGYDGASGLLKMKENGSFTIGQDENSCI
                     VYGMPMVAFDRGSVMLQLPLGEISNCLIRHINILKQKD"
     gene            complement(3452..4255)
                     /locus_tag="KNP36_001390"
     CDS             complement(3452..4255)
                     /locus_tag="KNP36_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-glutamate O-methyltransferase CheR"
                     /protein_id="HBF0873272.1"
                     /translation="MIKLTDEEFIVLVNHVKKEYGIDLSKKRALIEGRLYNTMIEKKL
                     SSFSQYMNLLFKDRTGNEAINLINRLSTNHTFFMREPQHFEFIQNSILPFWEENNKIR
                     NINIWSAGCSSGEEAYSIAMTLDDYFGYNKELWNIKIIATDISTNSLEKAKRGIYIES
                     NVNNVPELWKKKYFIDNKDGTFKICDKIRKSVIFKPFNLMNDFSYQHFDLIFCRNVMI
                     YFDLKTREELINKFYNATKKDSFLFVGHAEVINRSSTKYKYVKPAIYKR"
     gene            complement(4291..4731)
                     /locus_tag="KNP36_001391"
     CDS             complement(4291..4731)
                     /locus_tag="KNP36_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheW"
                     /protein_id="HBF0873273.1"
                     /translation="MAKDEIIKQVLTFYVNDVIYGIELENVIETIRFQSITYVPCLPT
                     YISGVINLRGRIIPVINMHIKYNLPKADYNERTCIIITKVDEYQVGIIVDKVVDVIHI
                     ENLNLLETTNSNNTNINKDIKEIAKVEDNSILILDIRKFLINSI"
     gene            complement(4744..6846)
                     /locus_tag="KNP36_001392"
     CDS             complement(4744..6846)
                     /locus_tag="KNP36_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheA"
                     /protein_id="HBF0873274.1"
                     /translation="MRQMLDMFIFETSLLLEQLDEIMIQIEKEKVFTHNNINETFRIM
                     HTIKGSASMMGLDNISALAHSVEDLFYAIREGKIEVLDNDLLFDLVFQSLDFIRRDID
                     ELQSRGCISSDYSNFIEGIEEYVSTLELSSSMKSKDNANLESKDEKEVIDSNFEYKED
                     SDVVKIIFEQGCMMENVRAFMLVFELRDYCEFIDFYPKDVETNAESTEYIKSYGFYIQ
                     FVAKEDKAIVYKTIEDNLYVKEYINISKKEIEMKSTSNNDAVENKLKDNNKVSKSYQN
                     NYTEDEIQEDVLNEKTDMEKDSLSEENEHLPISKQSIMSVNLEKLDLLQNIVGEIVIM
                     ESMVVNSVNSTGVDIDNFNKATRQLHKLTDELQDIVMSMRMIQIAGVFQKMHRIVRDM
                     NKKLDKNVELITIGAETEVDKSVIDNLAEPFMHLIRNAMDHAIEPIEERIAKGKEEVG
                     KIVLSAENLGGEAVISISDDGRGIMRDKILAKAKEQGLLKHQSNEYTDDEVNSLIMTP
                     GFSTKESITEFSGRGVGMDIVRKSIEKVGGSIEVKSKQDEGTTFTIKIPLTLSIVEGM
                     KFKVGDSLFTLPISSIRRTFKLTDLNQIITEGNKTELITIYGACIPIIRLHKIYNIQT
                     KVTNLMNGNMIIIENEHKAVCIFVDEIIGNQQVVVKPFPVYFNRFNIKNKGLSGCTIL
                     GDGSISLIIDADSIIEIY"
     gene            complement(7107..8810)
                     /locus_tag="KNP36_001393"
     CDS             complement(7107..8810)
                     /locus_tag="KNP36_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing protein"
                     /protein_id="HBF0873275.1"
                     /translation="MKREVKLSKLAIVLLIIIVLAVLAGIFSSISSYKAFEKVEKSIN
                     DMNNLRTQSQYIKDTTREISDVLRRYVFTGEKKNKDIYEKELYGKTRESALNKLEKIG
                     LTKSESNKILEAKEISDSLVPTEQSAIKAVESNDKSKAQSIIFGSDYINSQEKMDSLI
                     NEFQEDIVTRSNSKIVEVKKELQSLILRTIFILSLLIILTIIEYTVIKLKIVIPINKV
                     EKHFSRIASGDLRTSIDVEESKSEIGLLVSSVKKMQSMLLNYIDLIDSTLTSIAKGDL
                     RVEIDQEFIGDFKSIKISLESIINSFNGDFSEINLSAEQVASASEQVAAGAQALSQGA
                     TEQASSVEELASTINEISDGIKKCADSASLACEVSDQSASQVGFGSRCMDDMMTSMGE
                     ISEKSSEISKIIKTIDEIAFQTNILALNAAVEAARAGQYGRGFAVVADEVRSLAGKSA
                     KAAQNTAILIEEAIKTVENGVRIAKETANALDLVVNGVEKTTNYINGISSAVHSQEVA
                     ITQILSGIEQISIVVQMNSATAEESAAASEEMSAQAQILKELVEKFHLKESEVRESSW
                     V"
     gene            complement(8836..9795)
                     /locus_tag="KNP36_001394"
     CDS             complement(8836..9795)
                     /locus_tag="KNP36_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0873276.1"
                     /translation="MKNKQQGTILVVDDSVLMCDLIDKTLTKDNFKVKKAFNAIEAKE
                     FIEEFIPDIILLDIILPDNSGFEFCKEVKSNARTADIPIIFITSKNTDTDIVKGFGVG
                     AIDYMVKPFSMTELKARVIAHLEVKKSQDKLKKINNELESSLEKLNRLVVRDYLTGLY
                     NRRHIINQLMEQRRINKYSETSISLILGDIDDFKVINDTYGHEAGDFVLTVISSIIKK
                     NCRQIDTVSRWGGEEFLIMLTNTPIEGAKILSERIRKEIKEFDFNYKEHKIKCTITLG
                     VVEVNSNISLEENISLADKAMYEGKNLGKDCSVVSTMKGLKKI"
     gene            complement(9931..10449)
                     /locus_tag="KNP36_001395"
     CDS             complement(9931..10449)
                     /locus_tag="KNP36_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-binding chemotaxis protein CheW"
                     /protein_id="HBF0873277.1"
                     /translation="MRFPDDPYLDYGLIDEGIKYLKFKVDEQDFGVELEKVIEITGNQ
                     EIIFIPELPTYSKGIINLRGKIIPIIDMRLRLKKDELMTTNCMYIVVTEIKDLVVGFV
                     VDRVDDIVSLEKSKISPPPRVTIEYSDYFVSGVGELEGKIITLLDLEKLLTDKDEVLI
                     DELINGFDCTIM"
     gene            complement(10492..10977)
                     /locus_tag="KNP36_001396"
     CDS             complement(10492..10977)
                     /locus_tag="KNP36_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheD"
                     /protein_id="HBF0873278.1"
                     /translation="MNREIVVNIADMKIAYRPNVLVTYALGSCVGVCLIDKVAGIGGM
                     LHVMLPYSKDAINIENKCKFADTGINELIKSMENIGANRIYIKAKIAGGAQMFLGSSN
                     SVIASIGHRNVEAVKKTLLGLNIPILAEDTGMNYGRTIRFYTETGELLVDSINKGKKK
                     L"
     gene            complement(10974..11591)
                     /locus_tag="KNP36_001397"
     CDS             complement(10974..11591)
                     /locus_tag="KNP36_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheC"
                     /protein_id="HBF0873279.1"
                     /translation="MINYLELDDVHIDALREIGNIGSGNAITALASMINSNVEVLIPM
                     VKILEYNEATNLLGGPENKVVCILLDMKGDINGMFMFLLDESITQLMLSSLFNKEEAF
                     LDEIEAIEISAIKEIGNIMASSYVNAIASMLNMTISVSIPDICIDMVGAVLNVPMIRF
                     SDVGDKVLFIENKFKMSDNYFTSHILMIPEMSSLREILVRLGLEV"
     gene            complement(11656..12018)
                     /locus_tag="KNP36_001398"
     CDS             complement(11656..12018)
                     /locus_tag="KNP36_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBF0873280.1"
                     /translation="MENKILIVDDAIFMRMIIKEALSKSGYNNLIEANDGEEACNIFK
                     YEKPDLMLLDITMPKKDGLEVLREIKKLDSSAKVVMCSAIGQENMIVEAIKLGALDFI
                     VKPFKTETLVKVVDNALK"
     gene            complement(12762..13259)
                     /locus_tag="KNP36_001399"
     CDS             complement(12762..13259)
                     /locus_tag="KNP36_001399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="effector binding domain-containing protein"
                     /protein_id="HBF0873281.1"
                     /translation="MNYEIVEINEKIVIGISKETTNKDGQAVNDIGELWKKFMGKGIY
                     NAIKGKKNDKTIGLYTDYQGDFTSPYSFVACCEVNSNSDKEKNLEELNTNNTVGESII
                     SKVIPAGKYAKFVIVGGQKEVGDFWFEFWQMDFDRTYISDFEEYQCNTFDTKKQEIHI
                     YIGIK"
     gene            complement(13434..14345)
                     /locus_tag="KNP36_001400"
     CDS             complement(13434..14345)
                     /locus_tag="KNP36_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YafY family transcriptional regulator"
                     /protein_id="HBF0873282.1"
                     /translation="MKINRLTEIIVILLNKKLVTAKELADRFEVSTRTIYRDIETLSM
                     SGVPVYMTKGKGGGISLIEEYSIDKAILSKKDKESLIVALKTLQATKYPEINSVVNKI
                     GSIFGEQNFSNWIEIDFTEWGSNFNEDDKFTKIKEAILRRNTINFNYVNSLSSQTNRT
                     VEPLKLMYKSKTWYLYGFCKLKDDFRIFRISRIRNLSIKDEVFSRKIIEEVCLNDSKV
                     IKENTITLKLRFKEKMLFRVFDDFNKDLITKNEDDTYDVITEFPIGEWIYGYILSFGD
                     NVEVLEPKDVRDNVITRLRELSKIYSL"
     gene            15269..16120
                     /locus_tag="KNP36_001401"
     CDS             15269..16120
                     /locus_tag="KNP36_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3100 domain-containing protein"
                     /protein_id="HBF0873283.1"
                     /translation="MEINKKHFIQVFLTCLILVVICEFIGQRTIAIGKASIVLFPMLY
                     AVIIGLIITPDLLGKKIKALKKVVGEKEINIAGEVVGIALVMLGIKYGTTVGPNIDKI
                     IQAGPAFIAQEFGHILAPIVALPLALMFGMKREAVGATASISREPSLGVISEKYGINS
                     PEGSGVLGTYLMGTVLGTIYFSVLGSISIYSGLHPYALGMACGVGSGSMMTAAAGSLS
                     TMVPPEMADTILAYAATSNMMSSITGIIFLVFVSLPFTNFMYKILEPKFSRNKKTKEI
                     KSTEGEC"
     gene            16124..16594
                     /locus_tag="KNP36_001402"
     CDS             16124..16594
                     /locus_tag="KNP36_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873284.1"
                     /translation="MFANLNLKKSSYQLLVMSVIGVIILIGQRISVGTSIVTALPGMV
                     MLILAAMAAMIIKDLFPKSIFPAFGFATIIGLLLSMPYSPTSEVFLTNTNNINFMAIT
                     TPLLAFAGISVGNKIEALKEMSWKIVIISLIVFTTIFFACASIAHIVLSIQGKI"
     gene            16607..17917
                     /locus_tag="KNP36_001403"
     CDS             16607..17917
                     /locus_tag="KNP36_001403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0873285.1"
                     /translation="MNKEQLKSLVIKTIDENREKILKIGQGIYKNPEYGYKEFKTTEA
                     VSNFFEQELNLSVEKNIAVTGCKADANSSKKGPHISILGELDGISCKEHKDANEIGAS
                     HTCGHNIQIAGMLGAAVGLVKSGVLEHLDGKVSFMATPAEEFIELEYREQLKKEGKIT
                     YFGGKQELIKRGYFDDIDISMMFHASDLGEDKALVGPESNGFVGKKVKFIGKESHAGS
                     APHDGINALNAAMLAINNVNALRETFKESERVRFHPIITKGGDIVNVVPADVHMESYV
                     RARTINGMIDANERINKALMAGGMAVGADVEITEIPGYLPILRYKSLDNLFKNNLEDL
                     GLKGKVIDGGDFTGSFDFGDVSHIMPTLHPMIGGVKGALHTRDFEIVDEDLAYIIPAK
                     AMALTVVDLLFDNAKDAKDILDTFTPVMTKEEYLTFLEKHDKTL"
     gene            18129..18875
                     /locus_tag="KNP36_001404"
     CDS             18129..18875
                     /locus_tag="KNP36_001404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0873286.1"
                     /translation="MFNAGNRIINTWLYPIQDGFVLIDTGYENGFKHFKKRISKFNIK
                     IKDIRYIFLTHAHDDHVGFLNQILDESPNTKIVMHDKALEILYKGQNSFIGGCTSRTA
                     FLFCQIMKLFGKGEHSFSPLKQEFEKRCILVSDKNRKEIEKELNGKIIDTPGHTDDSI
                     SLLIDEGVLFCGDSAMNGFPSTHKITIFAESKLEFIQSWKTIINTKPKMIYPGHGKPF
                     EYSKLEQNLIYVNKINLYPLHNSKDIHRFL"
     gene            19237..20778
                     /locus_tag="KNP36_001405"
     CDS             19237..20778
                     /locus_tag="KNP36_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBF0873287.1"
                     /translation="MNDNVVKKKNFFDRTLNRIETVGNKLPDPVTIFLGLCVLLLILS
                     SLVGSMGISVVHPGTGETITAVNLLTVEQLQILLGNIVSNFQGFAPLGLVLVTMIGAG
                     VCDKTGLMTATIKASVSKIPETRVTLVVMTIGMLANIASDAGTILFPPLAALVYLGVG
                     RHPLIGLFSGYAAVCLGFAANIMISVNDILAASFTVPAAQMIDSGFQANATMNLFFMI
                     ASTFVLILLATWVTEKIVAPRFGKYEGNAELDVDGSLSDVEKKGLKKASISILIYVAI
                     IVALSVIGKKPFLADPETGDLLSNNAPLMKGMVPIIALAFFIPGVVYGKTIGKIKKDK
                     DVVSIMASAMSDMGGYIILAFAASQFLQLFTNSNLGLILAVKGGEFLKSAGINGPLLL
                     IGFIILSCFINLFIGSASAKWAILAPIFVPMFMMVGYNPALTQMAYRIGDCITNPLSP
                     LFPYFPIILAFTRKYDKDAGMGTVIANMIPYSISFLIVWTILLILFMVFNIPLGPGIL
                     PSYSM"
     gene            20813..21919
                     /locus_tag="KNP36_001406"
     CDS             20813..21919
                     /locus_tag="KNP36_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HBF0873288.1"
                     /translation="MLDKNRLINNFMDMVRIDSPSNQELEMSKWLVNYLKERNIDAII
                     DDAGEKYGGNTGNVIAYIKGEEGSRPLCLCAHMDQVQPCLGVKPILDGNVVRSDGTTT
                     LGADDKAGIAAILEALEHVITEKIPHRDIYLCFTICEEAGMHGVKNFNPDNLPCKDMV
                     ILDSGGAIGSIAYKAPAQQSIKISFQGKKAHAGIEPEKGLNAILVASHAISNMHIGRI
                     DSLTTSNIGEIEGGGATNIVTDKVTLTAEIRSHIPETLEYELNHMEKCCKDAASKFNT
                     TYTFEHNMSYPSFELSRDSHVFKLSEEAIRQVGVVPNPMVIGGGSDANILANLGYNCA
                     ILSLGMYDVHTVNEYVNIDELYDTAKIVYHMIKL"
     gene            complement(22298..23584)
                     /locus_tag="KNP36_001407"
     CDS             complement(22298..23584)
                     /locus_tag="KNP36_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBF0873289.1"
                     /translation="MIVGIIGPSDSGFKIKDDLKQIDSDLKTKIYVREKVVDTIEVIS
                     KCEDECDAIIFTGCAVYEFIKSKYEISKPHSFVPRSGTSIMKAFWAIKSANIKLDKFS
                     IDVVDRYVVEDALKEFDIKATSVFCNPFSLEVGESELVEWHIKLFEENKTDIMLTGFG
                     AVYNELKERGYPVFRLQATIQLIKESYDKVKSEYALSKARFSQIAVEILSLIDYKEKI
                     DNYYSDMIKKSDMDKLVVNYVRSIQGSLFLLGRNDYVVFVHKGVADNEYNYDKLFNLK
                     REIKDMGFSLSIGIGTGVTAYQAENNAHKALRHSIDSKEIGIYLVDEDENIRGPLASE
                     NELNYSLMLSDEKVIEISKKTGMSCESVAKIIAINENRKSKIYDSKELAEYLNVSERS
                     ARRILNKIVNAGLGRICAKETSIGGGRPKNITEILF"
     gene            complement(23707..26805)
                     /locus_tag="KNP36_001408"
     CDS             complement(23707..26805)
                     /locus_tag="KNP36_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBF0873290.1"
                     /translation="MDVINLIDELDEIVYVSSLDTYELLYINEIGKKAMGLNDISHLK
                     CYKALQGKDSPCEFCTNSILKEDEYYIWENTNTRTNRHFILKDKLIKWEGKHARLEIA
                     LDITEKEDISKSIAEKLEIKELLVGCIKHLITESNFSDAVNLVLTNIGKFHKADRAYV
                     FEVSEDRKKVTNTYEWCNEGVDEQKQALTNLDINELKNWFLLFEQKGFVIIDDIENIK
                     EEQPIEYEILKPQKIESLMTSSLKQDDKVVGFIGVDNPHKAVGDTSLLTSLSYFLLTE
                     MKKRKVENKLNYMSYYDFLTGAYNRNKYIKYIDNFQKGKVKSIGVVFVDINGLKDIND
                     NFGHANGDSAIVSACVIIKKYFHSYNVYRIGGDEFVVLCEDISKQLFEELVSWLSEEF
                     KDEMIYSVAVGSIWSDDNIDIHKLIKVADERMYQDKKRYYNKNKLRNNEMKVISDLAD
                     STNNILFKHKELVDKVYFDDLMIKGYSKAYEKLAYNTYDIILSICIDTNLITPIYQSE
                     SNIFSFPIKENLEKTFSYIKKHLIHPDDIILFNDNHLLKSLDSLNNSKQDDLELNFEY
                     RRLGIDKKYYWALIYMLKISSKNKLGEKQTHILVAIKNIDYLMQLHKNQKDTLTGLYN
                     YESFCEQISLMLKRYPDKRYAIIMMDIDKFKVINDIYGVRGGDKALIYVAELIQKNIG
                     SNGICCRMYADVFCIFYESYSDRDIHKVIYKIKNSLNRKKFEYMLVPCFGVYRILDNH
                     IPITNACEMAGYAHKKVKKQSINNYIFYDDTIRNDALEEKQMEREMEYALENGQFHVY
                     LQPKYNLNANKIVGAEALVRWVHPEKGIIPPIKFISLFEKNGFIIRLDMYVWEQVCSL
                     IRKWIDLGEEPVPISVNVSRLHLHNPHFKEIVLSLINKYSIPKSFLELELTESLFIKN
                     IKLFTKIIADLRMDGIVLNMDDFGSAYSSLNMLKNINIDTLKIDCGFFNEEGITDREK
                     IVLKHTIAMAKDLDMDVVAEGVETKEQAEFLVTLDCVVIQGYYYCKPIPSADFEKLLY
                     QK"
     gene            27531..27689
                     /locus_tag="KNP36_001409"
     CDS             27531..27689
                     /locus_tag="KNP36_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873291.1"
                     /translation="MKIFSFLLFVIGICLCIAGFIGHYPVFVGTTLSFLAIAMIAVRQ
                     VKTKKKMK"
     gene            complement(27976..28680)
                     /locus_tag="KNP36_001410"
     CDS             complement(27976..28680)
                     /locus_tag="KNP36_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873292.1"
                     /translation="MEIKPLVLIVEDDKPICKFIKVSLETQNYRCVETDNGGTAISLI
                     HSLDPDLIILDLGLPDIDGIEVIGRVRACAKTNKIIVVSAREHERDKVEALDGGADDY
                     LTKPFSVTELLARVRVALRNKAQQDNINNDAPKSFEVKNLKIDYENHIVSINGEEIHL
                     TPIEYKIIELMSKYSGRVLTHKFIIDKVWGNYYESENQSLRVFMASIRRKIEKNPAQP
                     EYILTEVGVGYRMADE"
     gene            complement(28671..30278)
                     /locus_tag="KNP36_001411"
     CDS             complement(28671..30278)
                     /locus_tag="KNP36_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4118 domain-containing protein"
                     /protein_id="HBF0873293.1"
                     /translation="MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGI
                     SVVFEKVGFNESNIILVYILGVLFATSITYGYFFGILSSVIGVLSFNFFFTHPLYTFL
                     AYRKDYPMTFCIMLMAAIITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKN
                     QIIEFCGSNLVNILNRTVIVTIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEA
                     FRTGNPVGIGTKYCKNSSAYYFPIKGQESNVLGVIGVACFKIDIITENEKILLEAVST
                     QVALAIDRENLFEKNKKANLEAERERLRGNLLRSISHDLRTPLTSILGSSSTILENDD
                     VIDKETRVELLKNIYEDTSWLTHSVENILSMTRIDEGKLDIEKRPEVVDEIIAESILR
                     VKKFANSRDIKTNIPDEIIIVHVDVLLIEQVLVNLIDNAIRHTPKNSKIELTVKKESN
                     QVLFEVADNGKGIPNEDIGNIFNRFYTKNKSRNLERRGIGLGLEICKSIVEAHGGEIV
                     AFNNPSGGATFRFSIPMYDEEGKDKWK"
     gene            complement(30532..31710)
                     /locus_tag="KNP36_001412"
     CDS             complement(30532..31710)
                     /locus_tag="KNP36_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873294.1"
                     /translation="MEKLSDKRRVKAVSMETFVFIVLLAVGFGYVGSIMGAGMMFKVI
                     MSTAHALLLDTVFLIMAMAVLAGALSALLSEFGVISLVNKIFKGLMRPIWGLPGASIA
                     GVVATYLSDNPAIIPFAKDKTFTQYFKKYQVPALCNLGTAFGMGLIVTTFMIAQGKEY
                     VLPAIIGNVAAIIGSIISVRIMLTFTKKYYNYDPKNDTEKQINDKGAKLEEFREIRDG
                     NVFQRTLDAILEGGKLGVEMGMAIIPGVLVVCTLVMLLTFGPSTDPATGQAVYTGAAY
                     EGIKLLPAIGDKISFIIEPLFGFTSPEAIAFPVTALGAVGAAISLVPEFIKSGAITPN
                     DIAVFTAMGMCWSGYLSTHIGMMDALDARPLAGKAILSHTIGGLCAGICAHFIFMLVG
                     "
     gene            complement(31936..32430)
                     /locus_tag="KNP36_001413"
     CDS             complement(31936..32430)
                     /locus_tag="KNP36_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBF0873295.1"
                     /translation="MHLFIEVIAAFFTALSFGVLFNMKGKNLILAGIGGSIAWFSYKF
                     LLNIGVTENLCFFIATVCFAIYCELCARIYMTPATTLSVCCLIILVPGYGIYNTMYSV
                     LTNNYIKAVEYGVSTLSCASSIALGLVFITTVFRKVNLYGVLTKIKENEKYKKSINKI
                     KQQK"
     gene            complement(32431..33192)
                     /locus_tag="KNP36_001414"
     CDS             complement(32431..33192)
                     /locus_tag="KNP36_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBF0873296.1"
                     /translation="MDIDRILNFSSNAGKAMLQSGGETYRVEETIARICQSFGIDHVD
                     VFATPTAVMASVFVDGKLHSAIKRISSRRVDLNLVHEVNSLSRAISINNLDIELCEKI
                     LDEISEDNYYSDLITIFFAGIAAATFSILFGGNVEEFIAAFTVGILTKFVIMYLSKSS
                     LNDFFVNAIGAVIIASCSILILKLGFIKTLDHLIAGAIMLLVPGLALTNALRDLLDGQ
                     LISGLAKLAEVFFVGVSIAVGMFLVLGLYFKLGGI"
     gene            33894..36728
                     /locus_tag="KNP36_001415"
     CDS             33894..36728
                     /locus_tag="KNP36_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0873297.1"
                     /translation="MLRKDKVLLSLHKLCENMTLKDLQSDKTGFTTIEIANHSSLDRS
                     NTSKELNNLYNEKKVLKISGKPILFLHASIIENLIGRTLNSDEFSINNCNELLKSSKN
                     DSEDIFSTLLGHDSSLKLPIEKAKSAILYPPKGLNTLLIGPTGVGKSTFAETMYKYAV
                     ESKIFSSESKFVVFNCAEYAENANLLLSNLFGYVKGSFTGANKDKFGIVAQADGGILF
                     LDEIHRLPPEGQEMLFLLMDKGIYRRLGESDIMHKANVFIVCATTEDIHSSLLGTFLR
                     RIPVTINLPALQDRSLKERLSLIKYFFIIESKYTNATIKVHKDVIKSLLLYDCFGNIG
                     QLKSDIQLMSARAFLNYKTGLKDNIEIDLSLVPDYIYIGLLKLNENRSNLNKLSELDY
                     MLFYEFNGNNLEVEYTKELSKYNIDTSNNGFKYSTEIPYLENDIRSMFINYMEKYSTK
                     LLSISSVTHSDYTSNEIFKVINPKIYYAVEHSLKEAEKISRNKYTKQTYIALSMHISA
                     LIENINQDTYNPKYNLYNDKIFLDKDLNIAKIVLSIIENDLQTSLPKDEVKFISMFLN
                     SMYLEPNNQSESIGVIILAHGNSTASSMCDVANSLLGTNHCNAIDMPLDVKVSTILDK
                     TIELVKECDEGKGVLLLTDMGSLIAFGELISEKTKIKTRSIEMVSTPIVLEAVRKSTL
                     PEMTLDELANSLSSLNPYIGRAAIDSTEINYPEKSREYVIITTCITGYGSAMKVADFI
                     NSSLKNISKYNINLVPHNIESFKMYKNKFSNTKILAVVGSVDFNVANTPFIHIEELLN
                     GYGLDMLNKIIEGTFNANSITNIKETNLSYNSLIINFMTQNLELLDSVKLFNYVNSSL
                     FTIIELIDENLKSKFKLGYILHCSFMIERCFKNTTFPYNNITELISKNHELYSLIREA
                     FKPTEAYFNILIPDEEIAYIIDMINEYLNK"
     gene            36771..38015
                     /locus_tag="KNP36_001416"
     CDS             36771..38015
                     /locus_tag="KNP36_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBF0873298.1"
                     /translation="MEDEILKGKIKQLTILALIFIFITPVFAFADTPPVPNSSRAALL
                     IDQETKRILFEKNIDEKMPLASLSKMMTFLLAIEAVDKNQVKETDMVKIDKSTASVGG
                     STCKLKDGDEISLGELMQGLMLVSGNDAAIAIAKHIGKTEKNFVNMMNKKAEEIGMID
                     TYYFNPNGLPIYTDPEHKEPPIENMSTAHDIVTLGKYMYDHYENQVTRITTMQVYNDT
                     KKDFTHYNTNPLLVSVPGVDGIKTGYTDNAGYCLAFSMMVPKDAKNERNHRLIGVVLG
                     DGNKKNRISSSATLLKYGKDNFHSKKIAHKGDIIETPCVDGIDDFKITVKVDKDLYGV
                     VSDNENINPKVVFKNMNYPIHKGDIVGVAKYYNDSGKFVGSVDVKSESNIGCIPLKDK
                     IKIKVAKINKKLEIKNSVCFKA"
     gene            complement(38430..40172)
                     /locus_tag="KNP36_001417"
     CDS             complement(38430..40172)
                     /locus_tag="KNP36_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873299.1"
                     /translation="MKKTINNNLFRILNIIVYKNKTKLIVSFIMVFIIAGVNIVIPQL
                     IRCIIDDGIGNKNIFLLINLILIYIFIRILSATFDVILSYLYTSIKNKVTINLKVKLL
                     NHISKLSGRYYSSKKTGNILSIMESDIFMIENFGAEIIFDIIVNVFTAIISLIFLINL
                     QFDLFLVVLFLQLILTFSQNKMTKLISKKISEIRSDSGSLSNLIQEYVSNIMDIVILN
                     SKKNFFNKYLKRERDLIKKDLNLNIIMSSNIAISQILTGLITILIYGIGGYKIINNKM
                     TMGELIAFQQYTGMLIGPCIAIVRANTRIAQSKVSINRVFSVIDEKIDIKVDNNGYRI
                     DNSEIKKIDFKNVSFRYGEDLNLVLNDINLQFEKGEVTGIVGGSGCGKSTITNLIYRL
                     WDINEGDILIDGVNIKDINLKSLRNNIDIVTQDQFVFDDTIKNNIVLNNKISDKELDE
                     ILEVTCLDDFIKNLDKGLDEVVGEKGVKISGGQKQRISIARALVSNKKVLILDEATSA
                     LDNISQKEILNNLKEYIQDKIVIIIAHRLSTIKSADNIYVLDKGRVIESGNDAELLHK
                     DGLYNKLVETADFA"
     gene            complement(40156..40830)
                     /locus_tag="KNP36_001418"
     CDS             complement(40156..40830)
                     /locus_tag="KNP36_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873300.1"
                     /translation="MKILKVKDLKKIYGKYENEVRALDGIDLDIEPHKFTAIVGASGS
                     GKSTLLHCVAGLDKPTLGNVYLDDVDLYTLNDDKLSEIRRQEFGFIFQSYNLIPVINV
                     YDNIVLPVLLDGKKEDKEYVMRLINKLGIEKQIKKYPNELSGGQQQRVAIARALANRP
                     SVIFADEPTGNLDSKTTNEVMNMLEWCVKEYKQTLVMITHNDNIAKTADRIITIKDGK
                     IDEKNY"
     gene            complement(40867..41856)
                     /locus_tag="KNP36_001419"
     CDS             complement(40867..41856)
                     /locus_tag="KNP36_001419"
                     /inference="COORDINATES: protein motif:HMM:NF012311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBF0873301.1"
                     /translation="MTKVRIAVLDTGLDVNDDDINGNYVYDSNFQLKDLGGKEINDIN
                     GHGTFVSKTILNISKNTQIYPINIFNDSGKTSSLNLLSTLSKLTMSDIQIINISAASI
                     NSMYEKELEKVCNILNSQGRFIICSKHNKYEDKESIPTIFESVIGVVGNENIYKNNQY
                     IYEPENKIQMYANSKDNFIKFKDKVTHFGKNSKACAVATGIVANILKNNPYIKFNELE
                     EILIQKSKSKEDLKIENLNTPSYKSNLIRLDIARKIINVINRNFSKIKIDFEFVSEYS
                     LFNNFTCIGNYNAYNFLTILNKEFNISIDYKEVYLYQLENLDMAVDLIYENLI"
     gene            complement(41904..43148)
                     /locus_tag="KNP36_001420"
     CDS             complement(41904..43148)
                     /locus_tag="KNP36_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0873302.1"
                     /translation="MNSSNKYFLDCICEKIINNNQVILSNKVNGRWVKIPIECYEVLK
                     YSVDNALQLGNLYDVFQENEDKKYYERVIDKLEHIGLLSDSILSEFRLERINKISFSP
                     TNRCNLSCDYCCVDSKIDNNDYLDTSQVRKVIDNIVKLNPRILTITGGEPLMRNDFLE
                     LLDYIKEKFKGKIILSTNATLIKEKQIDDIINGLYAIEISLDGYDELSCSEVRGKGVF
                     CKVLNVIRLIKLKKFENVGLSMVVGKNNEKDIEKFNKLNEDLGTTPIIRNFMNIGRGN
                     ENYSKYLNDKLDIDYICKDDYVDESSLCSNMCKAGVNQISIDHKGDVYPCPNLEYKDL
                     KIFNILEFNENILERILNREMDIFNIFDKLKPVNIESCKECKVNLFCTTCPSKIYTLK
                     NNKKMFDANCKKMKNILEPILW"
     gene            complement(43190..>44022)
                     /locus_tag="KNP36_001421"
     CDS             complement(43190..>44022)
                     /locus_tag="KNP36_001421"
                     /inference="COORDINATES: protein motif:HMM:NF014717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873303.1"
                     /translation="NVLLVNNFYSRIKLSNNTQIIKSPKIGDLIDIKIPVYKDGEYKY
                     INTKVRIAGIMKNSYISEQDGESQSGGIQIIFNEKDLKELTGISDYNKVFVKIKKETD
                     KKVIKEINNIIEKSGFSDIEGRYVRNHFGDHYNKSSYKLAMICVFGVLLISSINIIFI
                     VRSNIIVRLSEICTFRAIGMSKKNVKRMLIKENMIYGVLSMIVAGIISSFNYYKIVSE
                     TNKLNQQVYGINNSIKFEIPIYEILIFGSISVFVCVIAVYFSNKMINKLSIVSGIKEN
                     "
BASE COUNT        14761 a         7324 c         4914 g        17023 t
ORIGIN      
        1 tataatttat actttgaaaa taaaataaac tatcttccaa acattttatt atatgcttaa
       61 aagatagttt tgtgtcttta aaataaatta aattgtatat attccttcac ataacttttg
      121 tatattacta ggtggttgcc atttaccatc ttttttagta tatgtaatca tagttgtaac
      181 ttccttagtt ggtttcttat tgtaaaggtc tataatcatt tttgtcatat catcttgaac
      241 ttctttttct tttttatcgt aattcttttc atcagttaca taagatttta ctaaagtgtt
      301 cgcttcactc attactttac tagtatctaa agctttactt acaactttca aagttatctt
      361 atccttacta gaagattcca ctgttactgt cttttcaaca ccttgaatta atttaacaat
      421 tgtttcgtat atcttttcag cattttcttt accataaaga ggtgtcaatt gagcaatcat
      481 tgaaaccttg tccttgctgt tataagtttg aatctgttta tattcagctt ctgttaatgc
      541 atcagaaatt cctttttcat catacttata catttctaat gcagctaaat tagcttcaaa
      601 attcgacttt actttttctt ctgcattaga acaccctata gttagaacta aaactagagc
      661 cataatcgta gataatatta acttttttac cattttcata caaacatcct ccctcaatta
      721 aaataataaa aaatttattt atcaacatta taacataaat ttgtctaact atagaattat
      781 tttgaatatt ttaccacttc cagtctattc caataccgtt ttcttttgct ttatcgtata
      841 ttctttttgc tgttacgaca tcttgtacac ctatcccaac agttttaaat acaattatct
      901 catcatcatc ttctcttcca ggaatagttc cgtttataac atttcctaaa tcaccactaa
      961 aatcatcttt acttatctta ccttctttta atggaattaa tatatctcct gactcagata
     1021 aaactgcatc tgttgattca aaaaatatct tagacgctct agttaaacag tttgggcaca
     1081 actcttgcat atctggcata tatgaaccta ctgcacttat taaagctcct tttttcacta
     1141 agtttccatt aagtactggt tgttttgatg gagtagctaa aactatcaca tctgcgttat
     1201 ctatggcttc gtcagatgat tcaactgcaa ctattttagt attatattta cttaatttta
     1261 agttcatttc ttctgcaaat ttttctctac tttccttgtt tctactaaaa actcttacct
     1321 catccaaatt tctagcttct atcatggctt caagttgtgg ctcaccttgt cctcctagac
     1381 ctatcaaagc tccaatctta gaatcttttt tagccaatac gtctatagct gctccagagg
     1441 ctgctccagt acgaatctga gttacataag taccatccaa tactgcacta acttctccag
     1501 tttctccatc taataatagt actgttgctg gaattactgg tttgcctttt tgagcatttt
     1561 taggaaatac agatacaatt tttattcccc cacagcctaa ttcttctacg tatcctggca
     1621 taaataacat actagcatct tgacttggaa cagatatatt ggttctcaaa ggatttacac
     1681 tctttccttc acaataaatt ctaaaagctt ccttatcagc ttcaattgca tctctcattg
     1741 taaatacttt ttttatgtcg tcttttttta aaagtagcat ttttataccc ccaattttaa
     1801 taagtctcta tgctaaatat tatagcataa catttaattt aatcttctat ttcaaatcaa
     1861 ataaatctac atactctggt tttagcatag aacttatcaa cgctttattt attgaaaatt
     1921 ctggtattcc tgctgcatat ggagttatat catacaaatc aaaatataca actagattct
     1981 catcttgcaa gtaaaagttt tgattctctt ttataccttt aaaattatat attccgatat
     2041 tttcttcatc ctttttttca agttcagcta tttgtctttt aatttcttca tctataactt
     2101 ctttatattt agtattatcc ttaaacaagt ccattaattc taaaaatttt ccagttctca
     2161 tatccacatt atatgctata tcttgataaa atccatgtgc tccaccacta taagtataat
     2221 atctcacttt tatactaaga gcagaatcag tattcttttt aagttcaaag tctacatttg
     2281 caacaaactt atttttctcg tcaggattat ccttaagata ctgctttgct tctttatatg
     2341 atttattata aaattcaaat atgtcatttt ttatcttatc atttgtagac ctttcaacaa
     2401 ttttatttga atttgttatt acaggcatgt ttatagtact ttctaaatac tcatcatttt
     2461 tcactattgt tttacttcct attgtactta ctgataaagt ttgtttacta tttgtattac
     2521 cctttggtaa tgactggtta ctcataacag tcactgcttc cttattacta tttaaattaa
     2581 ttgaagcatc tttccttaaa ttattatatt tatagtcatg tttaattgcc aaaacagcca
     2641 ttatagtcaa tgttaaaaca aatacatatc ttaaaacttt agcttttgta tcgactttaa
     2701 aaaatttcat attatcattt tcctcctaaa tataaatctc tcttattata tttggagttt
     2761 ctagggtttt ttatccatat aatttaataa aagattaatt tttatttata aaaaattaat
     2821 ctttttgttt taaaatatta atatgtctta tcaaacagtt tgaaatttca ccaagaggta
     2881 attgtaacat aacagaacct ctatcaaaag ctaccattgg cattccatat actatacaag
     2941 aattttcatc ctgtccaatt gtaaatgaac cattttcttt catttttaaa agtccacttg
     3001 ctccatcata acccatacct gtaagtatta ttcctattga atttttacct gctacttctg
     3061 ctactgaatc aaacaaaacg tctactgatg gacagtgacc acttattctt tctccttttt
     3121 cacaagttac ataatatcct tgtttatccg tacacaattt catctggtaa cccccaggtg
     3181 caattaacac atttccttgt tctactctat cattattctt agcttctctt acattcataa
     3241 tacactgctt gtcaagccgt tgtgcataca tataagtaaa tatagctggc atatgttgaa
     3301 ctacaacaat ccctggtgtt gattttggta ggtcttttat aatttcaagt attgcctctg
     3361 taccacctac agatgcgcct atagcaataa ccatattatt aaaacgttcc acattaccgc
     3421 ctccaaaaaa tcatatatca aaaatacctt tttatcgttt atatatagca ggttttacat
     3481 atttgtattt agtactactt ctgttgatta cttctgcatg tcctacaaac aaaaaactat
     3541 cttttttggt agcattataa aatttattta taagttcttc tcttgttttt aaatcaaaat
     3601 aaatcataac atttctacaa aaaatcaaat caaaatgttg atatgagaaa tcattcatta
     3661 aattaaacgg cttaaaaatt acactttttc taatcttatc acaaatttta aatgtaccat
     3721 ccttgttgtc tataaaatac ttcttcttcc ataactcagg aacattgtta acatttgatt
     3781 ctatgtatat acctctttta gctttttcaa gtgagttagt tgaaatatct gtggctatga
     3841 ttttaatgtt ccacaactct ttattatatc caaaataatc atccaaagtc atagctattg
     3901 aatacgcttc ttctccacta gaacatcctg cactccatat atttatgttt cttattttat
     3961 tattttcttc ccaaaaagga agtatactat tctgtataaa ctcaaaatgt tgaggttctc
     4021 tcataaaaaa tgtgtggtta gtactcaatc tatttattag gtttatagct tcatttcctg
     4081 tcctatcttt aaataataga ttcatatatt gactaaaaga actaagtttt ttctctatca
     4141 ttgtattgta taagcgacct tcaattaacg ctcttttttt acttaaatca ataccatatt
     4201 ctttttttac atggtttaca agaactataa attcttcatc tgtgagtttt atcatgcaaa
     4261 aacttcctcc tgctaattta tcagaactaa ctatatgcta ttaatcaaaa actttcgaat
     4321 atctaaaatt aatatagaat tatcttcaac tttcgcaatc tcttttatat ctttattaat
     4381 attagtgttg ttagaattag tcgtctctag taaatttaga ttttctatat gaataacatc
     4441 aacaacttta tctacaataa ttccaacttg atactcatca acctttgtaa ttattataca
     4501 agttctctca ttataatcag ctttaggaag attgtacttt atatgcatat taataactgg
     4561 tattattctt cctctcaaat taataactcc acttatatat gttggaagac atggtacata
     4621 cgttattgat tgaaatctta tggtttcaat cacattttct aattctattc cataaataac
     4681 atcattgaca taaaatgtta atacttgttt aataatttca tctttagcca tactttaaat
     4741 cccctaatat atttctataa tgctatctgc atctataatt aaacttatac ttccatcccc
     4801 aagtattgta catcccgata aacccttatt ttttatatta aatcggttaa aataaactgg
     4861 aaatggtttc acaacaactt gctgattacc tattatttca tcaacaaaaa tgcatactgc
     4921 tttatgctca ttttcaataa ttatcatatt accattcatc agattggtta cttttgtttg
     4981 aatattatat attttatgta accttataat gggaatacat gctccatata ttgtaattaa
     5041 ctctgtctta tttccttctg taattatttg atttaagtct gtaagtttaa atgttcttct
     5101 tatggatgat attggtaaag taaatagtga atctccaact ttaaacttca taccctctac
     5161 tatagaaaga gttaatggta tttttatagt aaaggttgtc ccctcatcct gtttactttt
     5221 tacttcaatt gaacctccaa ctttttcaat acttttacga acaatgtcca tgcctactcc
     5281 tcttccagaa aattcagtta tagattcttt tgtagaaaag cctggagtca taatcaaaga
     5341 attgacctcg tcatcagtat actcattact ttgatgttta agaagacctt gttccttagc
     5401 ttttgccaaa atcttatctc tcataatgcc tctaccatca tctgaaatac ttatcacagc
     5461 ttctccgcct agattttcag cagataaaac tatctttccc acttcttctt tacctttcgc
     5521 tatacgctcc tcaataggct ctattgcatg gtccatagca tttcttataa ggtgcataaa
     5581 aggttccgct aaattatcaa ttacactctt atccacctct gtttctgctc ctatagttat
     5641 taactctaca tttttatcta attttttatt catatctcgt acaattctat gcattttttg
     5701 aaatacacca gcaatttgaa tcatacgcat agacattact atatcttgca attcatctgt
     5761 aagcttgtgt aattgtcttg ttgccttatt gaaattatct atatcaacac ctgtagaatt
     5821 tacgctattt acaaccattg attccataat tacaatttct ccaactatat tttgaagtaa
     5881 gtccaatttt tctaaattta cactcataat actctgctta cttattggta aatgttcatt
     5941 ttcttcactt agactatctt tttccatatc agttttttca tttaaaacat cttcttgtat
     6001 ctcatcttct gtatagttat tttgataact tttacttact ttattattat cttttaattt
     6061 attttctact gcatcattgt ttgatgtact tttcatttct atttcttttt tactaatatt
     6121 tatgtattct tttacataga gattatcttc tatagtttta taaactattg ccttatcctc
     6181 tttagctaca aattgtatat aaaacccata acttttaata tactctgtag actctgcatt
     6241 tgtttctaca tcttttggat aaaaatctat aaattcacag taatctctaa gttcaaatac
     6301 aagcatgaaa gctctcacat tttccatcat gcaaccttgt tcaaagatta tttttactac
     6361 atcagagtct tctttgtatt caaaatttga atcgattact tctttttcgt ctttactttc
     6421 taaatttgca ttatcctttg atttcataga acttgataat tccaaagtac tcacatactc
     6481 ttcaattcct tcaataaaat tagagtaatc agaagatata caacctcttg attgtaactc
     6541 atctatatct cttcttataa aatctaatga ttgaaagact aaatcaaata ataggtcatt
     6601 gtctaaaact tctattttac cttcacgtat agcataaaac aagtcttcta cactatgtgc
     6661 taaagcagat atattgtcta accccatcat agatgctgaa ccttttatcg tatgcattat
     6721 tctaaaagtt tcattaatgt tgttatgagt aaatactttc tctttttcta tttgaatcat
     6781 aatttcatct aattgttcga gtaataaact tgtctcaaat ataaacatat ctaacatttg
     6841 tctcatactc ggttcaatat aattcacatt tatcacctac gacctacaaa taattttcta
     6901 ttatatatgc atctcataat ttaaatcctt gatgattctc ttatctcact atatgtacct
     6961 cataatttaa atacacaatt attctcttac ttcaatatat atacatctca taatttaaat
     7021 ccttgataat tctcttattt caatatatat acatctcata atttaaatac atgataattc
     7081 tcttacttca atattcacct cataatttaa acccatgatg attctcttac ttcactttcc
     7141 tttagatgaa atttttctac taattctttt aaaatttgag cctgagcaga catctcttct
     7201 gaggctgctg cactttcctc tgctgttgct gagttcattt ggactactat ggaaatttgc
     7261 tctattccag ataaaatctg tgtaattgct acttcttgac tatgtacagc cgaagaaata
     7321 ccattaatat aattagtagt tttttctaca ccatttacta ccaagtccaa tgcatttgca
     7381 gtctctttag caattctgac accattttct actgttttaa tagcttcttc tatgagaata
     7441 gctgtatttt gagctgcttt tgcactttta ccagccaaag acctaacttc atctgctaca
     7501 actgcaaatc ctctaccata ttgacctgct cttgctgctt caacagctgc atttaatgca
     7561 agaatattag tttggaatgc tatctcatct attgttttga ttatttttga tatttcactc
     7621 gatttttcac ttatttcacc cattgatgtc atcatatcat ccatacatct acttccaaaa
     7681 ccaacttgtg atgcagattg gtcagatacc tcacatgcaa gactagcact atctgcacac
     7741 ttcttaattc catctgatat ctcattaatc gtggaagcta attcttctac tgaactagct
     7801 tgttcagtag caccctgtga aagagcttgt gcacctgctg caacttgttc tgaagcactt
     7861 gcaacttgct ctgctgataa atttatttca gaaaaatcac cattaaaaga gtttattata
     7921 ctttctaaag atattttaat tgatttaaaa tcacctataa attcttggtc tatctctact
     7981 cttaaatctc cttttgcaat actagttaat gtactgtcta taaggtctat gtaatttaaa
     8041 agcatacttt gcatcttttt gacagaactc actaatagcc ctatttcaga tttactttct
     8101 tcaacgtcta tacttgttct taagtcccca gatgcaattc ttgaaaagtg tttttctact
     8161 ttattaatag gaatcactat ttttaatttt attactgtat attctattat tgtcaatatt
     8221 attaaaaggg aaagtataaa tattgttctt aatattagac tttgtaattc tttttttact
     8281 tctacaattt tggaatttga acgggtaact atatcctctt gaaattcatt tattaaagaa
     8341 tccattttct cttgggagtt tatatagtca ctaccaaaaa ttatactttg agctttactc
     8401 ttatcattac tttcgactgc ctttattgca ctttgttctg ttggtactaa agaatctgat
     8461 atttcttttg cttctaagat tttatttgac tcgctctttg taagaccaat tttttctaat
     8521 ttgtttaaag ctgattctct tgtttttccg tataattctt tttcataaat atctttattc
     8581 tttttttctc ctgtaaatac atatcttctt aatacatcac ttatctctct agttgtatct
     8641 tttatatact gactttgagt cctcaaatta ttcatatcat taatactttt ttctactttt
     8701 tcaaatgctt tataagatga aatagaagaa aaaatccctg ctagaacagc caatactata
     8761 ataatcagca atacaattgc taatttagaa agctttactt ctcttttcat atctgtactc
     8821 cttcataaag taagtttata tcttttttaa tcctttcatt gtactcacta cgctacaatc
     8881 ttttcctaag tttttaccct catacattgc tttatctgct aaggatatgt tttcttctaa
     8941 tgatatattt gagtttactt ctactactcc taatgtaata gtgcacttta ttttatgttc
     9001 tttatagttg aaatcaaact cctttatctc tttacggatt ctttctgaaa gtatcttagc
     9061 accttctatt ggagtatttg tgagcattat caaaaactct tctccacccc atcttgatac
     9121 agtatcaatt tgtctacaat tcttttttat tatacttgat attactgtta acacgaaatc
     9181 ccctgcttca tgcccataag tatcattgat aaccttaaag tcatcaatat caccaaggat
     9241 aagggatatt gatgtttcac tatatttatt aattcttctt tgctccataa gctgattaat
     9301 tatatgtcgc ctattgtaaa gacctgtaag ataatctctt acaacgagtc tattcaattt
     9361 ttcaagagaa gattccagtt cattatttat cttttttaat ttatcttgag atttctttac
     9421 ttcaagatga gctataacac gagcttttaa ttctgtcata ctaaaaggtt tcaccatata
     9481 gtcaattgct cctacaccaa atccttttac tatgtctgta tctgtatttt ttgaagttat
     9541 aaaaattata ggtatatctg ctgtacgagc attagatttt acttccttac aaaactcaaa
     9601 accagagtta tctggtaaaa ttatatcaag caaaataatg tctggtataa attcttcaat
     9661 aaattctttt gcctctattg cattaaatgc ttttttaacc ttaaaattat cttttgtaag
     9721 tgttttatct attaagtcac acatcagaac actatcatca acgactaaaa ttgttccctg
     9781 ttgcttattt ttcatataca aacctctctt aaacataata tattcaaatt ttaatgattt
     9841 aaaattttta tacttaataa ttataccact atattcttaa atgttctcat cacaatcttt
     9901 ttataataac actccaacta catccctatg ttacatgata gtgcaatcaa acccattgat
     9961 taattcatct attaaaactt catctttatc tgtcaaaagt ttctccaaat ctagtaaagt
    10021 aattatttta ccttctaatt ctccaactcc acttacaaaa taatccgaat attctatagt
    10081 aactcttggt ggaggtgata ttttactttt ttctaagctt actatatcat caactctatc
    10141 aaccacaaat ccaactacca agtcctttat ttcagttact actatataca tgcaatttgt
    10201 agtcattaat tcatcttttt taagtctcaa acgcatatct attatcggaa tgatttttcc
    10261 tcttagattt attatgcctt tagaatatgt aggtagttct ggaataaata taatttcttg
    10321 atttccagta atttctatta ccttttcaag ttcaacccca aaatcttgct catctacttt
    10381 aaactttaga tacttaattc cttcatcaat tagtccataa tctaaatatg ggtcatctgg
    10441 aaatctcatt taatacctcc ctcctaaaat acactttcta tgaaatatat attataattt
    10501 cttcttacct ttatttattg aatctacaag taattcaccc gtctcagtgt aaaaacgtat
    10561 tgttctacca taattcatac ctgtgtcctc agctaatatt ggaatattta atcctaaaag
    10621 agtttttttt actgcctcaa cattcctatg tcctatactt gcaattactg aattgctact
    10681 tcctaaaaac atctgagcac ctccagcaat ttttgctttt atatatattc tatttgcacc
    10741 tatattctcc atagatttaa tgagctcatt tattcctgtg tcagcaaatt tacacttatt
    10801 ttcaatgtta atagcatctt tactatatgg caacataacg tgtaacattc caccaattcc
    10861 agctacttta tctatcaaac atactcctac acaagaacca agtgcataag taactaaaac
    10921 atttggtcta taggctatct tcatatctgc aatgttcact actatctctc tattcatact
    10981 tctaatccca acctcacgag tatttctcta agtgagctca tttctggaat catcaaaatg
    11041 tgactagtaa aataattatc actcatttta aatttatttt ctataaataa gactttgtca
    11101 ccaacatctg aaaatcttat cataggtaca tttagaacag ctccaaccat atcaatacat
    11161 atatctggaa ttgaaacact tatagtcatg tttaacatag atgcaatagc atttacatat
    11221 gaacttgcca taatatttcc tatttcctta attgctgaaa tttcaattgc ctcaatctca
    11281 tctaaaaaag cttcttcttt attaaaaaga gaacttagca taagttgagt tattgattca
    11341 tccaacaaaa acataaacat tccattgata tcacctttca tatcgagtaa aatacatact
    11401 actttgtttt ctggaccacc aagcaaattt gtcgcttcat tatattcaag tatcttgacc
    11461 ataggtatta atacttctac attgctattt atcatggatg caagtgcagt aattgcattc
    11521 ccagagccta tattaccaat ttctctaaga gcatctatat gaacatcatc aagttctaaa
    11581 taatttataa tataaacccc tccctttatt attgcattta tttgcttttc attgtattag
    11641 tgtatattta cacttttatt ttaaagcatt atctacaact ttaactaatg tttctgtttt
    11701 gaagggcttc actataaaat ctaacgctcc aagttttatg gcttctacaa tcatattctc
    11761 ttgtcctatt gcagagcaca ttacaacctt agcacttgaa tccaactttt ttatttctct
    11821 tagcacctct aaaccatctt tttttggcat tgtaatatca agcaacatca aatcaggctt
    11881 ttcatattta aatatattac acgcttcttc tccatcattt gcttctatta aattattata
    11941 gccactttta ctcagagctt ctttaattat cattctcata aaaatagcat catctactat
    12001 caaaatttta ttttccataa aactaactcc tccatatgta caacaataaa cgcttttatc
    12061 ttcagttatt gtctatacta tctgactatt tttcgctaca caataaatac atttcattga
    12121 taaataaaag taattattta tgccatatta tacttaattc tcttaacata atttgtcaac
    12181 aaaaaaactt atatatctat tgtaatatat gtttggcgtt ttgacgagtt attaaaaata
    12241 taattgtata aaacataaaa agttatcaaa agtaattaaa ttataataaa acaactttat
    12301 acctttttta tgtttgtata aaaaaaattt tcagattcat taaaatcatt tctgtagatt
    12361 catataggat ttgactttct caatatctaa tagatagttg tttatttact taattatatt
    12421 tctctatatg tattatcgat taaattagat ttagctttat acattatttt ttatattttt
    12481 caaattgtat actcataaat ccagaagtat tctaatgtgt ttataatact ttttttcata
    12541 ttttaaatta aataacaaat cattatattt acaagtatca tttatcaata aacaatatta
    12601 aatgaagaat atgtctgaag attcaaagtg atactgatac tattaattac taaaaaagca
    12661 gtaaatcttt tacagattta ctgcttatag ttataaataa taaaactatc tataataaat
    12721 gtactatact caatatttca ttcaatatag taataacaaa tctactttat tcctatgtaa
    12781 atatgaattt cttgtttctt tgtatcaaaa gtattacatt gatactcttc aaaatcactt
    12841 atataagtcc tatcaaaatc catttgccaa aactcaaacc aaaaatctcc tacttctttt
    12901 tgacctccta ctataacaaa ctttgcatac ttacctgctg gtataacttt actaataata
    12961 ctttctccaa cagtattatt agtgtttaat tcttctaaat tcttctcttt atcagaatta
    13021 ctatttactt cacaacatgc aacaaagcta tacggacttg taaaatcacc ctggtaatct
    13081 gtatatagac ctattgtctt gtcattcttt ttacccttta tagcattata tatccctttg
    13141 cccataaatt ttttccacaa ttcacctata tcatttaccg cttgtccatc tttatttgta
    13201 gtctccttcg atattcctat aactattttc tcatttatct ctactatttc ataattcata
    13261 ctttatacct cactttgttt ttattaatct attttatttt gaactaattc aattataatt
    13321 tataatatac gacaccttta tgtcatattt ttaatataat taaactcagt gagatattat
    13381 atactaaatg caagatatta tatatttaat aaaatcttta atctagcatt atattataat
    13441 gaataaattt tagacaactc ccttagtcta gttattacat tatccctaac atctttaggt
    13501 tcaagtactt caacattgtc accaaatgat aaaatatatc cataaatcca ttcaccaata
    13561 ggaaattctg taattacatc atatgtatca tcttcatttt tagttattaa atccttatta
    13621 aaatcatcaa atactctaaa aagcatcttt tctttaaacc tcaatttcaa cgttatagta
    13681 ttttccttaa ttactttaga atcattcaaa catacttctt ctattatctt tcttgaaaat
    13741 acttcatcct ttatagataa attccttatc ctactaattc taaatatcct aaaatcatct
    13801 tttagtttac aaaatccata caagtaccaa gtcttactct tatacataag cttcagtggt
    13861 tcgacagttc tgtttgtctg gcttgacaaa ctatttacat aattaaaatt tatagtatta
    13921 cgccttaaaa tagcttcttt tatttttgta aatttatcat cttcattaaa attacttccc
    13981 cattcagtaa agtctatttc aatccagttt gaaaaattct gctctccaaa tattgagcca
    14041 attttattta ctactgaatt tatttctgga tacttagtcg cctgtaatgt tttcagtgca
    14101 actattaaac tctctttatc tttttttgac aatatagcct tgtctataga atattcttct
    14161 attaaagata tccctcctcc tttgcctttc gtcatatata ctggtactcc cgacatagac
    14221 agagtttcta tatctctata tatggttctt gtagaaactt caaatctatc tgccaactct
    14281 ttagctgtta ctaatttttt atttaataga attactatta tttctgttaa tctatttatt
    14341 ttcattcatt accacctact aaaattatta aatttattta atctaaatta atcatactaa
    14401 tttttaaata aataaaatct tagaatctta tctaaattat ttttacatga ttttatttac
    14461 tttctattat ctttctcact ttggatatta tcatcttaat ttatttatta ctatatcaat
    14521 ttacttatta tcatctcatt tgttatcgtc ttacttaatt tacttatttc tatatcaatt
    14581 cacttattat tacctcactt gttatcatct tacttaattt acttatttct atatcaattt
    14641 acttattatc atctcatttg ttatcgtctt acttaattta cttattgcta tgtcaattca
    14701 tttattatta tctcacttgt tatcgtctta cttaatttac ttatttctat atcaattcac
    14761 ttattatcat cttaattcat ttgcttatta tcatttactt tattcaattt ctatatcaaa
    14821 attagtattt gtacttaata cttaaaatta atttaaagtc tttacatatt atttattttc
    14881 tattgtaata ttcatttcca tactttacta agctacttcc actcatttat tttaaaattt
    14941 caatttacta tttctcaact ctatattatt atttttcaat tttatattac taattttaaa
    15001 gctttttagc tattattcct acaatattta aacaattttt tcataataaa gctatattac
    15061 aatatattca aaatatgtaa tattttagat atttttcgtt gacaatgtta aatttttgtt
    15121 ttatccttaa ttaaggacat gttattgaca tttctgaaac ttatttgaaa tagttttttc
    15181 attttattta ggaaaacgta ttatacttaa gaaaacgtat tttctcattt cagataagta
    15241 aaatatttat tcttttgggg aggaaatcat ggaaattaat aaaaaacatt ttattcaagt
    15301 atttttaact tgcttaatct tggtagtaat atgtgaattt atagggcaaa gaactatagc
    15361 tattggaaaa gcctctatag tactgttccc tatgctttat gcagttataa ttggacttat
    15421 aataacacca gatttattag gtaaaaaaat taaagcactt aaaaaagtgg ttggagaaaa
    15481 agaaataaat attgctggtg aagttgttgg aattgcacta gtaatgcttg gtataaaata
    15541 tggtactaca gttggaccaa acattgacaa aataattcaa gctggaccag cgtttatcgc
    15601 tcaagaattt ggtcatatac ttgcaccaat cgttgcatta cctcttgcat taatgtttgg
    15661 aatgaaaaga gaagctgttg gagctactgc aagtataagt cgtgaacctt ctttaggagt
    15721 tatatcagaa aaatatggga taaactcacc agaaggtagt ggtgtacttg gtacatattt
    15781 aatgggaaca gttcttggta ctatatactt tagtgtacta ggttcaatat ctatttatag
    15841 tggtcttcac ccatatgctt tgggaatggc ctgtggtgtt ggtagtggaa gtatgatgac
    15901 agcagctgct ggttcattat ctaccatggt accacctgaa atggcagata caatacttgc
    15961 ctatgctgca acaagcaata tgatgtctag tataacagga attatattct tagtttttgt
    16021 atccttacca tttactaatt ttatgtataa gattttagaa cctaaatttt cgagaaataa
    16081 aaaaactaaa gaaattaaat ctacagaagg agagtgctaa taaatgtttg ctaatttaaa
    16141 tttaaagaaa agttcatatc aattattggt tatgtctgtt attggagtta taattcttat
    16201 aggacaaaga attagcgttg gtacatctat agttacagct cttcctggta tggtgatgct
    16261 aatattagct gctatggcag ctatgattat aaaagattta tttcctaaat caatctttcc
    16321 agcttttgga tttgcaacta taatcggcct tttacttagt atgccatata gtccaacatc
    16381 tgaagtattc ttaactaaca ctaataatat taactttatg gctataacta ctccactact
    16441 agcttttgca ggaatttctg ttggaaacaa aatagaagct ttaaaagaaa tgtcatggaa
    16501 aatagttata atttcactta ttgtatttac aactatattc tttgcatgtg cgagtatagc
    16561 tcatatagtt ttaagtattc aaggtaaaat ataggaggaa tttattatga ataaagaaca
    16621 attaaaatct ctagtaataa aaactataga tgaaaataga gaaaaaatat taaaaatagg
    16681 tcaaggaata tacaaaaatc cagaatatgg atataaagaa tttaaaacta cagaagctgt
    16741 ttcaaacttt tttgagcaag aattaaattt atctgtagaa aaaaatatag cagttacagg
    16801 atgcaaagca gatgcaaatt ctagcaagaa aggtcctcat atatctatac ttggagaatt
    16861 ggatggtata tcatgtaaag aacataaaga tgctaatgaa ataggtgctt ctcatacttg
    16921 tggacataat attcaaatag ctggaatgtt aggtgctgct gttggtttag taaaaagtgg
    16981 cgttttagaa catttagatg gtaaagtatc ttttatggct actcctgctg aagagtttat
    17041 tgagttggaa tacagagagc aattaaaaaa agaaggaaaa ataacttatt ttggtggaaa
    17101 acaagaatta ataaaaagag gttattttga tgatatagac atatctatga tgtttcatgc
    17161 ttctgattta ggagaagata aggctctagt tggtcctgag agtaatggat ttgttggaaa
    17221 aaaggttaaa tttataggta aagaatctca tgctggttct gctccacatg atggaataaa
    17281 tgctttaaat gcagcaatgc ttgctataaa caacgtgaat gcacttagag aaacttttaa
    17341 agagtctgaa agagttagat tccaccctat catcacaaaa ggtggagata tagtaaatgt
    17401 tgttcctgct gatgttcata tggaatcata tgttagagct agaactataa atggtatgat
    17461 tgatgctaat gaaagaataa ataaggcttt gatggctggt ggaatggcag ttggagctga
    17521 tgttgagata actgaaattc ctggatatct tccaatatta cgatacaaaa gtcttgataa
    17581 tttatttaaa aacaatcttg aagatttagg tctaaaagga aaagttattg atggtggaga
    17641 ttttacaggc tcttttgatt ttggagatgt gtctcatata atgcctactc ttcaccctat
    17701 gattggtggt gtaaaaggag ctcttcatac aagagatttt gaaatagttg atgaagattt
    17761 agcttacata attcctgcta aagcaatggc acttacagtt gtagaccttc tttttgataa
    17821 tgctaaggat gctaaagata tattagatac ctttactcca gttatgacta aagaagaata
    17881 tctaacattc ttagaaaaac acgataaaac tttataagtc tatttttata atagggtggt
    17941 atctactgta aaagttatac cactctttgt ttttgtaaca gtatacttct tttcttttag
    18001 tttttagatt aaactaaaat atattatcct ccttaaaact tttagagcta cgttgaaata
    18061 tcagtagaac tatgctatat tctttctaat taatataaat ttctattcta attcaaggtg
    18121 gtgaaaaaat gtttaatgca ggaaatcgaa ttataaatac atggttgtac cctattcaag
    18181 atggctttgt cttgattgat actggatatg aaaatggttt taaacatttc aaaaaacgaa
    18241 tttctaaatt caacataaaa atcaaagata ttcgatacat atttctaact catgctcatg
    18301 atgaccatgt tggttttcta aatcagattc tagacgaatc tcctaataca aagattgtta
    18361 tgcatgataa agctttagaa attctatata aaggtcaaaa ctcttttatt ggtggttgta
    18421 ccagccgtac tgcctttctc ttttgccaaa ttatgaaact atttggaaaa ggtgagcata
    18481 gtttttctcc acttaaacaa gaatttgaaa aaaggtgtat tcttgtgtct gacaagaatc
    18541 gtaaagaaat tgaaaaagaa ctaaatggaa aaattataga tacaccagga catactgatg
    18601 attcaatttc actactaatt gatgaaggtg ttttattttg tggagattct gcaatgaatg
    18661 gatttccaag tactcacaaa attaccatat ttgcagaaag caaactagaa tttattcaat
    18721 cttggaaaac aatcatcaat acaaaaccta aaatgattta tcctggacat ggaaaaccat
    18781 ttgaatacag taaattagaa caaaatctaa tctatgtaaa taaaataaat ttatatcctc
    18841 tacataattc aaaagatatt cacagatttt tgtagaaaat acaaagtaaa tttatttgat
    18901 taattaaaaa atctaacact ttactacgct acttatttta ataacttaat cttccactag
    18961 cttttcataa aattttgttt taaaattaat tttaaagtgc atatgttatt taaatacatt
    19021 agataaaatt cgtcattaat ctacttaaag catatttaac taacaccact caaccagaaa
    19081 attcagaaaa ctgcattgac acaggaaaaa gtttatttta tacttttttt aggacatatt
    19141 gtggacacgt cttaaatcga caaacagaat ttaaattgta agattaacca caatacttat
    19201 tttttaatta tatttttaaa cattagggag gatattatga atgataacgt agttaagaag
    19261 aaaaactttt ttgacaggac attaaacaga atagaaactg ttggtaataa actaccagac
    19321 ccagttacaa tatttttagg gttatgtgta cttttactta tactatctag tctagttggt
    19381 tctatgggta tatcagtagt tcatcctggt actggagaaa ctataaccgc tgtaaattta
    19441 ttgactgtag aacagcttca aattctttta ggaaacatag tcagcaattt ccaagggttt
    19501 gctcctttgg gtctagttct agtaactatg ataggtgctg gtgtatgtga caaaacagga
    19561 cttatgacag caacaatcaa agcatcagta agcaagattc ctgaaacaag agtaactctt
    19621 gttgtaatga ctataggtat gcttgccaat atagcttcag atgcaggtac aatattattt
    19681 ccaccattag ctgcacttgt atatcttggt gttggtagac atccacttat aggtttattt
    19741 tctggatatg cagcagtctg tctaggattt gccgcaaaca ttatgataag tgtcaatgat
    19801 atacttgctg caagttttac agttccagca gctcaaatga ttgattctgg atttcaagcc
    19861 aatgcaacaa tgaacttatt ttttatgata gcatcaactt ttgttctaat acttttggca
    19921 acatgggtaa cagaaaaaat tgtagctcct agatttggta aatatgaagg aaatgcagaa
    19981 ctagatgttg atggaagtct tagtgatgta gaaaagaaag ggcttaaaaa agctagtata
    20041 agtatattaa tatatgtggc tattatagta gctcttagtg taatcggtaa aaaaccattc
    20101 ttagctgacc cagaaacagg agatttacta tcaaacaatg ctcctcttat gaaaggtatg
    20161 gtacctataa tagcactagc atttttcata cctggtgttg tatacggaaa aactataggt
    20221 aaaataaaga aggataagga tgtagtctct ataatggcta gtgcaatgag tgatatgggt
    20281 ggatatataa tactagcatt tgctgcttca caatttttgc aattattcac aaatagtaat
    20341 ttaggtctga tactagctgt aaagggcgga gaatttttaa aatcagcagg aataaatgga
    20401 cctttattgt tgataggatt tattatatta tcatgtttta taaatttatt tataggtagt
    20461 gcatctgcaa agtgggctat tcttgcacct atatttgtac caatgtttat gatggttgga
    20521 tacaatccag cacttactca gatggcttat cgtataggtg attgtataac aaatccactt
    20581 agcccattat ttccgtactt ccctattata ctagcattca caagaaaata cgataaagat
    20641 gctggtatgg gtactgtaat tgctaatatg ataccatact ctatatcatt cttaatagtg
    20701 tggactatac tattaatatt gtttatggta tttaatattc cactaggacc tggaatactt
    20761 ccttcatata gcatgtaatt tatttaaatc tttctaaaag gagaaataat ttatgttaga
    20821 taaaaataga cttataaata attttatgga tatggttaga attgatagcc catctaatca
    20881 agaattagaa atgtctaagt ggttggtaaa ctacttaaaa gaaagaaata tagatgccat
    20941 tatagatgat gcaggtgaaa aatatggtgg taatacaggt aatgtcattg cctatataaa
    21001 aggtgaagaa ggaagtagac cactttgttt atgtgcacac atggaccaag ttcaaccttg
    21061 tttaggtgta aaaccaatac tagatggtaa tgtagttaga agtgatggaa ctactacact
    21121 tggtgcagat gataaagctg gaatagctgc tatacttgaa gctttagaac atgttattac
    21181 agaaaaaata ccacatagag atatttatct ttgttttaca atctgtgagg aagctggtat
    21241 gcatggtgtc aaaaacttta atcctgacaa cttgccttgt aaagatatgg tgattttaga
    21301 ttctggtgga gctattggtt cgatagcata caaagctcct gctcaacaat ctataaaaat
    21361 ctcttttcaa ggaaagaaag cacatgctgg tatagaacct gaaaaagggt taaatgctat
    21421 attagtagcc tctcatgcaa taagcaacat gcacataggc agaatagatt cattgactac
    21481 ttcaaatata ggtgaaatag aaggtggtgg agctacaaac atagtaactg ataaggttac
    21541 attgactgct gaaattaggt ctcatatacc tgaaacttta gagtatgagc ttaatcatat
    21601 ggaaaaatgt tgtaaggacg ctgcatctaa atttaatact acttatactt ttgaacataa
    21661 tatgtcttac cctagttttg aacttagtag agatagtcat gttttcaagt taagtgaaga
    21721 agcaataaga caagttggtg ttgttccaaa tccaatggta attggtggtg gaagtgacgc
    21781 aaatatatta gctaatcttg gatataattg tgctatatta agtctaggta tgtatgatgt
    21841 acacacagtt aatgaatatg taaatataga cgaattatat gatactgcca aaatagttta
    21901 tcatatgatt aaattataaa tatcataata gaactcttta aattataaaa ataaaaacct
    21961 atgtatcctc aactttataa gttatatatt agagttgttt tacataggtt ttagtatttt
    22021 tatataataa tttgttttaa catttttcat aataagcttt gatattttat atagtaattt
    22081 gttctaacat ttttcataat aagcttcaat attttgcata ataatttatt ctagcatttt
    22141 taataatagg ctctagtatt ttatattaat aatttattct agtattttac ataattattt
    22201 gttctaattt ttttcataat aagctttaat actttatata gtaatttgtt gtagaatttt
    22261 atacaatata atgatttata cagttttata aaatatctta aaacagtatt tcagtaatat
    22321 tttttggtct tcctccacca atactagtct cttttgcaca tattcgacct aaacctgcat
    22381 ttactatttt atttaatata cgtcttgcac ttctttcact tacatttaga tactctgcta
    22441 actcttttga atcataaatc ttactttttc tattctcatt tatagcaata atttttgcaa
    22501 ctgactcaca actcattcca gtctttttag atatttcgat taccttttca tcagatagca
    22561 tcaaagaata atttaattca ttttcggaag ctaaaggtcc tcttatgttt tcatcttcat
    22621 ctaccaaata tataccaatt tcttttgaat ctatggagtg tcttaatgct ttatgtgcat
    22681 tattttcagc ctgatacgca gttactccag taccaattcc tatactaaga gaaaagccca
    22741 tgtcttttat ctctctcttt agattgaata gcttatcata attatactca ttatcagcta
    22801 cccctttatg aacaaataca acataatcat ttcttccaag taaaaataag gaaccttgaa
    22861 tgcttcttac atagtttact acaagcttat ccatatctga tttttttatc atgtcagaat
    22921 aatagttatc tatcttctct ttataatcta ttaaactcaa tatttcaaca gcaatttggg
    22981 aaaatcttgc cttacttaga gcatattcac tctttacctt gtcataactt tctttgatta
    23041 attgtatagt agcttgtaaa cgaaatacag gatagcctct ttcttttaat tcattatata
    23101 ctgcaccaaa accagtcaac attatatccg tcttattttc ttcaaataat tttatatgcc
    23161 attctacaag ttcagactct cctacttcca aagaaaatgg attacaaaat acactcgttg
    23221 ctttaatatc aaattcttta agtgcatctt ccacaacata tctatcaact acatctatac
    23281 tgaatttatc taattttata tttgcacttt ttattgccca aaatgccttc attatactcg
    23341 tcccacttct cggtacaaat gaatgtggct tacttatctc atacttagat tttataaatt
    23401 cataaactgc acatcctgta aatataatag catcacattc gtcttcacat ttagaaataa
    23461 cttctattgt atctactact ttttctctta catatatttt agtctttaaa tcactgtcta
    23521 tctgttttaa atcatccttt atcttaaacc cagagtctga aggacctata atacccacta
    23581 tcataaactt cgctcctaat ccataaatat tatacttttt aaaaattata tcctcactat
    23641 tttctacttc tatttaatta ttttgaacta ctccatccta cctacattta gaatggaata
    23701 attagcttat ttttgataaa gtaacttctc aaaatcagca cttggaatag gcttacaata
    23761 ataataacct tgaattacca cacaatctaa agtcactaaa aattcagctt gttcttttgt
    23821 ctctacacct tctgccacta catccatatc taaatctttt gccatggcta tagtgtgctt
    23881 taaaactatt ttttctctgt ctgtgattcc ttcctcatta aagaaaccac aatctatctt
    23941 taatgtatca atattaatat tttttaacat atttaatgaa gaatatgctg aaccaaagtc
    24001 atccatattt aaaacaatac catccattct aaggtcggct attatcttag taaataattt
    24061 tatattttta ataaataaac tttctgtaag ctctaattct aaaaaagatt ttggtatact
    24121 atatttattt attaaactta aaacaatttc tttaaaatgt ggattatgca aatgtaatct
    24181 tgatacattt acagagatag gaactggctc ttcacctaaa tctatccatt ttctaatcaa
    24241 agaacatact tgttcccata catacatatc taatctgata ataaacccat tcttctcaaa
    24301 tagtgaaata aatttaattg gaggtattat acctttttct ggatgaaccc atctaaccaa
    24361 tgcttctgca ccaacaattt tatttgcatt aagattatac ttaggttgta aatatacatg
    24421 gaattgccca ttttcaagtg cgtattccat ttccctttcc atctgttttt cttcaagtgc
    24481 atcatttctt atagtatcat cataaaatat atagttattg atactttgtt tctttacttt
    24541 tttgtgagca tatcctgcca tttcacacgc atttgtaatt ggaatatgat tatccaaaat
    24601 tctataaacc ccaaaacatg gtactaacat atattcaaat ttttttctat ttaagctatt
    24661 tttaatctta taaattacct tatgaatatc tctatcagag taactctcat aaaaaatgca
    24721 aaatacatct gcatacatac gacaacatat accattagaa ccaatgtttt tttgaatcaa
    24781 ctctgcaaca tatattaaag ctttatctcc tcctctaact ccataaatgt cattaattac
    24841 cttgaactta tctatatcca tcattataat tgcataacgc ttgtcaggat atcttttaag
    24901 cattaaactt atttgttcac aaaaactttc ataattgtat agtcctgtta atgtatcttt
    24961 ttggttttta tgtagttgca taagataatc tatatttttt atagcaacta aaatatgtgt
    25021 ttgtttctca cctaacttat ttttactact aatctttaac atataaatta atgcccaata
    25081 gtacttttta tctattccta aacgtctata ctcaaaattt agttctaaat cgtcttgctt
    25141 gctattatta agactatcaa gagattttag aaggtggtta tcattaaata atattatatc
    25201 atcaggatga attaaatgtt tttttatgta tgaaaaagtt ttttcaagat tttcctttat
    25261 aggaaaacta aaaatattgc tctctgattg ataaattgga gtaattaaat tcgtatcaat
    25321 gcaaatagat aaaattatat catatgtatt ataagctaat ttttcataag ccttagaata
    25381 cccttttatc attaaatcat caaaataaac cttatcaact aactctttat gtttaaataa
    25441 aatattattc gtcgaatcag ctaagtcact aattactttc atttcattat ttctaagttt
    25501 gttcttatta taatacctct tcttatcttg gtacattctc tcatcagcaa ctttaattag
    25561 cttatgtata tcaatattat cgtcactcca aatactgccc actgctacac tatatatcat
    25621 ctcatcctta aattcttcac ttaaccaact cactaattct tcaaatagtt gttttgatat
    25681 atcttcacat aatacaacaa actcatctcc tccaatacgg taaacattat aagaatgaaa
    25741 gtattttttt attattacac atgctgacac aatagcagaa tcgccattag catgtccaaa
    25801 gttatcatta atatctttta acccatttat atctacaaat acaactccta tggatttaac
    25861 ttttcctttt tgaaaattat ctatatactt aatatattta tttctattat atgcaccagt
    25921 caagaagtca tagtagctca tataatttaa tttattttct acttttcttt ttttcatctc
    25981 agttaataaa aaataagata gggatgtcaa aagagaggta tctccaacag ctttatgtgg
    26041 attatcaact ccaataaacc ctactacttt atcatcttgt tttagtgaag atgtcattaa
    26101 actttcaatt ttttgaggtt ttaaaatttc atattctatt ggctgttctt cttttatatt
    26161 ttctatatca tcaattatta caaaaccttt ttgttcgaat aataaaaacc aattctttaa
    26221 ttcattaata tcaagatttg ttagtgcctg tttttgttca tcaacacctt cattgcacca
    26281 ttcatatgta ttagttactt tttttctatc ttctgatact tcaaaaacat atgctctatc
    26341 agctttatga aatttaccaa tattggttaa tacaagattt acagcatcag aaaaattaga
    26401 ttctgttata agatgtttaa tacatccaac taataactcc tttatctcta atttttctgc
    26461 tattgactta cttatatctt ccttttctgt aatatcaaga gctatttcta atcgtgcatg
    26521 tttgccctcc catttaatta acttgtcctt taatataaaa tgtctatttg ttcgagtatt
    26581 cgtattttcc catatgtaat attcatcttc ttttaaaata gagtttgtac aaaattcgca
    26641 gggagaatct ttcccctgta atgctttata acattttaaa tgggatatat cattaagtcc
    26701 cattgccttt ttcccaattt cattaatata taaaagttca tatgtatcta aagaagaaac
    26761 atatacaatt tcatccaact catctattaa atttattaca tccatttata tatatctcct
    26821 tttattcatt ttccagattg aatttttaaa gcttttaaaa ttttgctata tatttggcaa
    26881 tgatattata tttctttatg ttttaaaata gtaccttaat gaggttctat tttttagtaa
    26941 atagaattat tattgtgtca atcgtacaat agagttttgt aatacctaat ttaatatatt
    27001 tataattaat tatctcatta tgtgtttata attaattctc atataaatga caaatctcca
    27061 cctcaattaa gtattccaat catatatgaa gataatactt cattcattta aaaatataaa
    27121 actattatat attaaaattt cttcaataat aaattatcta gattgttact ttgatatatt
    27181 atataatatc acaaaggctg atataaaaag acaaaaaggg caattttttt atatcaaaaa
    27241 aaaatgttaa attgatatta tccatatata aattgatatt atccatatag atgctatatt
    27301 taacaattct acttacttcc cttacactta ttagcatata gttattaaga gtttgttgca
    27361 aaacaacact tagcacactt taaaaagtgt ggtctaataa gtaatcaacg aagaagacat
    27421 aataaagcat aaaatatgat atacttttcc acgccatcaa aactgaggat tttattatta
    27481 atatatgcta aaatatgctt aataaattaa attttaatgg gagaatagtt atgaaaatat
    27541 ttagtttctt gttgtttgtg ataggaatat gtttatgtat tgctggattt ataggacatt
    27601 acccagtatt tgttggtaca acattgagtt ttcttgcaat tgcaatgata gctgtaagac
    27661 aagtcaaaac taagaaaaaa atgaaatagg caaatcctaa ctttacaagt taatattaca
    27721 caagtaatta gtctaaaatt ggatactttt tctattacag aaatacatca tccactttgt
    27781 attttcttaa aaaaataaaa tagctatgta aattcaagat tagatagatt aactctctat
    27841 ccatttcatt gtaaaatata catagctatt tgtattcgat ttaaaatact tagattttct
    27901 tacataacaa ataatttcta tctgattatt actcatattc atttagtaac cactcagcaa
    27961 ctaatcattt agtatctatt catccgccat acggtaacct accccaacct cagtcaaaat
    28021 atattctggc tgagcaggat tcttttcaat tttccttctt atacttgcca taaaaactct
    28081 aagcgactga ttttcacttt catagtaatt tccccaaact ttatctatta taaacttatg
    28141 ggttaagact cttcctgaat acttagacat caactcaata atcttatatt cgattggagt
    28201 taaatgtatt tcttcaccat taattgacac aatatgattt tcataatcta tctttaggtt
    28261 tttaacttca aaagactttg gagcatcatt atttatatta tcctgttgag ctttatttct
    28321 aagagccaca cgtactctag ccaaaagctc tgttacacta aaaggtttag ttaaataatc
    28381 gtctgctcct ccatctaaag cttccacctt atccctctca tgctctctcg ctgaaacaac
    28441 aattatttta ttagtctttg cacatgccct aactcgtcct attacctcaa tcccatcaat
    28501 atctggtagt cctaaatcca aaattatcaa atctgggtca agagaatgta taagtgatat
    28561 agctgttcct ccattatctg tctctacaca cctataattt tgagtttcaa gagatacttt
    28621 tataaattta caaattggct tatcatcttc tacaattaga actaatggct ttatttccac
    28681 ttgtctttcc cctcctcatc atacataggt atgctaaatc taaatgtagc tcctccagaa
    28741 ggattattaa aggcgacaat ttctccacca tgagcttcta ctatagattt acatatctcc
    28801 aatccaagac caatacctct tctttcaaga tttctagact tattcttagt ataaaaccta
    28861 ttaaaaatat tcccgatatc ttcatttggt attccttttc cattatctgc aacttcaaat
    28921 agtacttgat ttgactcttt ttttacagtt agttctatct tagaattttt aggtgtatgc
    28981 cttatagcat tatcaattag atttactaac acttgttcta ttaataatac atccacatga
    29041 acgattatta tctcatctgg aatatttgtt tttatgtctc tactattggc aaactttttg
    29101 actcttaata tagattcagc tattatttca tcaacaactt ctggtcgttt ttcaatatcc
    29161 aattttcctt catctattct ggtcatacta agtatattct caacagaatg agttagccaa
    29221 ctcgtatctt catatatatt tttcaataat tctactctag tttctttatc tatcacatca
    29281 tcattttcaa gtattgttga agatgaacct aatatacttg taagtggagt tcttaaatca
    29341 tgagaaattg acctaagcaa gtttcctctt aatctctctc tctctgcctc aagatttgct
    29401 tttttatttt tctcaaataa attttctcta tcaattgcca acgcaacctg tgttgaaact
    29461 gcttctaata gtatcttttc attttctgta ataatatcta tcttaaaaca cgcaacacct
    29521 ataacaccaa gaacatttga ttcttgacct tttataggga aataatatgc actgctgttt
    29581 ttacaatatt ttgtcccaat tccaactggg ttacctgtcc taaaagcttc ttttatagct
    29641 tctttttcta atactgaatg gaatatattc tcacttccat cattgttaca aatataaata
    29701 cttggcttac ctagattatt attctcatct gcaatagtca ctattacagt tctatttaat
    29761 atatttacta aattagaccc acaaaattca ataatttgat ttttattttt tgctttaagc
    29821 aacgttttgt tattctcata gagcaatctt atcatttttt ctctcttatg agaaagtctc
    29881 acttctcttt ttatcctaga agttaaagta cttgttataa ttgctgccat tagcataata
    29941 caaaaggtca taggataatc ttttctataa gctaaaaaag tatataatgg atgcgtaaag
    30001 aaaaaattaa atgatagcac tcctattact gaagaaagta ttccaaaaaa atatccatag
    30061 gttatacttg tagcaaatag tacacctaat atgtatacta gtataatatt agattcatta
    30121 aaacctacct tttcaaaaac tactgatatt ccagtagcaa ttgtcataac caatatagtt
    30181 tttatgaagt ccttaataat tatcttttta ctgagatagc catcttcatc ataatcatac
    30241 tcttttaagt cttcatgttg tagtcgttcc tttttcattt actacaattc ctccttattg
    30301 ttactgttta aattggctct attttatata atacaatttt atcataataa attcaatcaa
    30361 tacatttaat taatgtactt aaattactaa aaggtgctgt cttaaaatga aaataaatct
    30421 ctatttcaaa acagcaccta tatatttaaa ttactaattt agtttttaca tacttaaatc
    30481 aatagtttta ttcaatttca taaattataa tacttcaatt ataaaacatt tctatccaac
    30541 aagcataaat ataaagtggg cacatatacc tgcacataaa ccacctatag tatgcgaaag
    30601 tatcgcttta ccagccaatg gtcttgcatc taaagcatcc atcataccta tgtgtgtact
    30661 taaatatcca ctccaacaca tacccattgc tgtgaatact gctatatcat taggagttat
    30721 agcgcctgat tttataaact ctggtactaa agatattgct gctccaacag ctcctaatgc
    30781 agttacaggg aatgctattg cctctggtga tgtgaatcca aataatggtt ctattatgaa
    30841 gctaatctta tcaccaatag caggtaataa ttttatacct tcatatgcag ctcctgtgta
    30901 aacagcttga cctgtagcag ggtctgtaga tggtccaaaa gttaataaca taactaatgt
    30961 acaaactact aaaactcctg gtattatagc catacccatt tcaacaccta acttaccacc
    31021 ttcaagtata gcatccaatg ttctttggaa tacattacca tctcttattt ctctaaactc
    31081 ttcaagtttt gcacctttat catttatttg cttttcagta tcatttttag ggtcataatt
    31141 ataatacttt ttagtaaaag tcaacataat tctaacacta ataatactac ctattattgc
    31201 cgcaacatta cctattatag ctggtagtac atattcttta ccttgagcta tcataaaagt
    31261 tgttacaata agtcccatac caaaggctgt tcctaaatta cataaagcag gtacttgata
    31321 cttcttaaaa tattgtgtaa atgttttgtc tttagcaaat ggtataatag ctggattatc
    31381 agataaatat gttgcaacta ctcctgctat actagcacca ggtaagcccc atataggtct
    31441 cataagaccc ttaaatatct tattaactaa agatattact ccaaactctg aaagcaatgc
    31501 actaagtgca cctgcaagaa ctgccatagc cattattaaa aatactgtgt ctaataaaag
    31561 cgcatgtgct gtactcatta ttactttaaa catcattcct gcacccatga tgcttcctac
    31621 atatccaaat cctaccgcca atagtacaat aaatacgaag gtttccatac ttactgcctt
    31681 gactcttctc ttatccgaca gcttttccat cttgaaatct tccccctttt aattttaaat
    31741 taaggttcct aacattggta caaatttttt ggtacaaact gagttctaaa acttacactc
    31801 gtaatgcaag ttgtcagttt tttgaaataa aaaaaaatta cgtttataga ataagaatat
    31861 cctctttaat ttggatactc ttattctatt ttatgttatt atattatcat ccttttgttt
    31921 aaaagtcaat tttttctatt tttgttgttt aattttattt atactctttt tatatttttc
    31981 attttctttt atctttgtaa gtactccata taagttgact tttctaaata cagtagttat
    32041 aaataccaat cctaatgcaa ttgaacttgc acacgataat gtactcaccc catattctac
    32101 agcttttata taattattgg tcaaaacaga atacatagta ttatatattc cataacctgg
    32161 tactaatatt attaaacagc aaacacttaa tgtagttgct ggagtcatat aaattcttgc
    32221 acataactca caatatatcg caaaacaaac tgtagctata aaaaaacata agttttctgt
    32281 tactcctata tttaaaagaa atttatatga aaaccaagct atacttccac ctattcctgc
    32341 tagtattaag ttttttcctt tcatattaaa tagcactcca aagcttaagg cagtaaaaaa
    32401 agctgctatt acttctataa acaaatgcac ttatatcccc cctaacttga agtacaatcc
    32461 aagtaccaag aacattccta ctgctataga tacacctaca aaaaatactt ctgctaattt
    32521 tgcaagacca gaaatcaact gtccatctaa caaatctctt aatgcattag tcaaagcaag
    32581 cccaggaact aagagcatta ttgctcctgc tattaaatgg tctaacgtct ttatgaatcc
    32641 gagctttaaa attaaaattg aacaagaagc tataataact gctccaattg catttacaaa
    32701 aaagtcatta agggaagatt tacttaaata cataataaca aacttagtca gaatcccaac
    32761 agtaaatgca gctataaatt cttccacatt tcctccaaat aatatcgaaa aagttgctgc
    32821 tgcaatacct gcaaaaaata ttgttattaa atctgagtaa tagttatctt cacttatttc
    32881 atctaaaatt ttctcacata attcaatatc taaattattt atacttattg ctcttgataa
    32941 tgagttaact tcatgaacca agtttaggtc tactcttctt gagcttattc ttttaattgc
    33001 tgaatgtaat ttcccatcta caaatacaga tgccattaca gctgttggag ttgcaaatac
    33061 atctacgtgg tctattccaa aagattgaca tattctagct atcgtttctt caactctata
    33121 ggtttctcct ccactttgca acatagcttt acctgcattt gaggaaaagt ttaaaattct
    33181 atctatatcc acaaaacata tctcccattc ttttatagta ttattcatat tttaatacaa
    33241 gatattattt atttaaacta ttttaaataa ttcatatcca atatttacat tttatgaaaa
    33301 aacttgtttt ttatgcttgt caaaatcaaa ttttaagctt gtttacacca taaaatggct
    33361 gaattaatat ttgacaaaca ctttcaacca tttatataac cttctaaatt gtataacttt
    33421 ttactacaaa taaaattata tctcttttaa ttctttctct tgagtattta gcttatagta
    33481 acttcatatt tatatatgta caatataaaa cattattttt atgatacaaa atataatttg
    33541 taaatgtata tatgtattaa ctgtgtatat ataaattatt cttgacctta tcagtttttt
    33601 catatatctt catctatacc aaccatatat taataaatga tattacatag acttaagtat
    33661 attaaaaaac ttaaatttag ttatttaaca acataatact ctaatttaat ctataaaaat
    33721 ccatacttaa tataatgcaa ctcttatttt aacaccatct attacacaaa acaacatatt
    33781 aaaaagtaaa atacaaaata tccactataa accttatttt aatactgaat atatattata
    33841 atatatttaa tgtagcttaa atatagttta aacataaaga aaggaaacgg tatatgctaa
    33901 gaaaagataa agttctatta tctctacata aattatgtga aaatatgact ttaaaagacc
    33961 ttcaatcaga taaaacagga ttcactacaa tagaaattgc taaccattca tctcttgata
    34021 gaagtaatac cagtaaagaa ttaaataacc tatacaatga aaaaaaagtt ctgaaaatat
    34081 ctggtaagcc aattttattt ctacatgcta gtattataga aaatttaatt ggccgtactt
    34141 tgaacagtga tgaattttct ataaataatt gtaatgagct acttaaatca agtaaaaatg
    34201 actcagaaga tattttttca acattacttg gacatgattc tagtcttaaa ctacctatag
    34261 aaaaagctaa atctgctata ctctatcctc caaaaggtct taatacgtta ctaataggac
    34321 ctactggtgt tggaaaaagt acatttgctg aaacaatgta caaatatgct gtagaaagta
    34381 aaatcttttc ttctgaaagc aaattcgtag tatttaactg tgctgaatat gcagaaaatg
    34441 ctaacttatt attaagtaat ttatttggtt atgtcaaagg ttcttttact ggtgctaata
    34501 aggataaatt cggcatagtt gcacaggctg atggaggcat attattctta gatgaaatac
    34561 acagattgcc accagaaggt caagagatgc tttttctttt gatggacaaa ggcatataca
    34621 gacgattagg agaatctgac attatgcaca aagctaatgt ctttattgtg tgtgccacaa
    34681 cagaagatat acattcttct ctgcttggga cttttttaag aagaatccct gttacaatca
    34741 acctacctgc tttacaggat aggtctttaa aagaaagatt atctcttatt aaatacttct
    34801 ttattataga atcaaaatac accaatgcaa ctataaaagt tcacaaagat gtaattaaat
    34861 cattactcct ttatgattgt tttggtaata taggtcagct taaatctgac atacaactta
    34921 tgagtgcaag agccttctta aattacaaaa ctggacttaa ggataatata gaaatagatt
    34981 tatcccttgt tcctgattac atctatattg gtcttttaaa attgaatgaa aatcgtagta
    35041 atctaaataa attatcagaa cttgattata tgctttttta tgaatttaat ggtaataact
    35101 tagaagttga atatacaaaa gaactatcta aatacaatat agatacatca aacaatggat
    35161 ttaaatactc tacagagatt ccttatctgg aaaatgatat aaggagtatg tttataaatt
    35221 acatggaaaa gtactctaca aaattacttt cgatatcttc agtaactcat tctgattata
    35281 caagtaatga gatttttaaa gtaatcaatc caaagattta ctatgctgtt gaacattctt
    35341 taaaagaggc tgaaaaaata tcgagaaaca aatacacaaa acaaacttat attgctcttt
    35401 caatgcatat aagtgcactt atagaaaata taaatcaaga cacatataat cctaagtaca
    35461 atttatataa tgataaaatt ttcttagata aagatttaaa tatagctaaa atagttttaa
    35521 gtataattga aaatgactta caaacatctt tacctaaaga tgaagtaaaa tttatatcca
    35581 tgtttctaaa tagcatgtat cttgaaccaa acaatcaatc tgaaagtata ggagtcataa
    35641 tacttgctca tggaaattca acagcaagca gtatgtgtga tgtagcaaat tcattgcttg
    35701 gtacaaacca ttgtaatgca attgacatgc ctcttgatgt aaaagtaagt accatacttg
    35761 ataaaactat agagttggta aaagaatgtg acgaaggtaa gggtgtactt cttttaacag
    35821 atatgggctc tcttatagct tttggagaac ttatttcaga aaaaacaaaa atcaaaactc
    35881 gctcaattga aatggtatct actccaatag ttttagaagc agtaagaaaa agtacactac
    35941 cagaaatgac tttggatgaa ttagctaatt ccttaagctc tttaaatcca tatattggac
    36001 gagcagcaat cgattcaaca gaaataaact atcctgaaaa gtcaagagag tatgtaataa
    36061 taactacttg tataacagga tatggttcag ctatgaaagt agcagacttt ataaattctt
    36121 cacttaaaaa tattagtaaa tacaatatta atttagttcc tcataatata gaaagtttta
    36181 aaatgtataa gaataaattt agtaatacta aaattctggc agttgttgga agtgtagatt
    36241 ttaatgtagc caacacccct tttatacaca tagaggaact actaaatgga tatggcctag
    36301 atatgctaaa caaaataata gaaggtacat tcaatgccaa tagtattaca aatataaaag
    36361 aaacaaatct atcatacaac agtttaataa taaactttat gacccaaaac ttagagcttt
    36421 tggactctgt taaattattc aactatgtca attcttcctt atttacaata atagaattaa
    36481 tagatgaaaa cttaaagagc aaatttaagc taggatatat actacattgc tcttttatga
    36541 tagaaagatg ttttaaaaat acaacttttc catataataa cattactgaa ttaattagta
    36601 aaaatcatga actatatagt ttaatacgtg aagcctttaa gccaacagaa gcttatttta
    36661 atattttgat accagacgaa gaaattgctt atataataga catgattaat gagtatctaa
    36721 ataaataaaa tttatagcac ttattttgtg catattaatt aatatatgaa atggaggacg
    36781 agattttgaa aggaaaaata aaacagttaa caatacttgc attaattttt atatttataa
    36841 ctcctgtatt tgcatttgca gatactccac cagtaccaaa ttcttcaaga gcagcactac
    36901 ttatagacca ggaaactaaa agaatattat ttgaaaaaaa cattgatgaa aaaatgccat
    36961 tagcgagttt aagtaaaatg atgacctttt tattggcaat agaagcagtt gataaaaatc
    37021 aagttaaaga gactgatatg gtgaaaatag acaagtctac agcttcagta ggaggttcta
    37081 cttgtaaact taaagatggt gatgaaatat ctctaggaga gcttatgcag ggtctaatgc
    37141 tagtatctgg aaatgatgct gctatagcca tagctaaaca tattggtaaa actgaaaaga
    37201 attttgtaaa tatgatgaac aaaaaagcag aagaaatagg aatgattgat acgtattatt
    37261 ttaatccaaa tgggcttcct atatatactg acccagaaca taaagaacct cctattgaaa
    37321 atatgtcaac tgctcacgat atagttacac ttggaaagta tatgtacgac cattatgaaa
    37381 atcaagttac aagaataacc actatgcaag tatataatga tactaaaaag gattttacac
    37441 attataacac aaatcctctg cttgtttcag tacctggtgt tgatggaata aagacaggat
    37501 atacagataa tgctggatat tgccttgcat tttctatgat ggtacctaaa gatgctaaaa
    37561 acgaaagaaa tcatagattg ataggtgttg tacttggtga tggtaacaag aaaaatagaa
    37621 tttcttcttc cgctacttta ttgaaatatg gtaaagataa tttccattct aaaaagatag
    37681 cacataaggg tgatattata gagactcctt gtgttgatgg tattgatgat tttaagataa
    37741 cagttaaggt tgataaagat ttgtatggtg ttgtttcaga taacgaaaat atcaatccta
    37801 aggtagtgtt taaaaatatg aattatccta tccataaggg agatattgtt ggtgttgcaa
    37861 agtattataa tgactctggt aaatttgttg gaagtgttga tgtaaaaagt gaaagtaata
    37921 taggatgtat tcctttgaag gataagatta agattaaggt tgctaagata aataaaaaac
    37981 ttgagattaa aaattctgtt tgttttaaag catagtaaag catattatta aaagggtatg
    38041 ttaaatttat aaagactcca ctttgtggag tctttttgtt ttttacaaaa aattaaaata
    38101 gtggcaacaa ttgaggatgt gagggagagt tgccactatt ttgtataggg tattatatta
    38161 tgtttttaag ctagttttac tatcttctat gtttatataa taactcttgt gtgtgaattt
    38221 aattgataat taatatgaaa attatgtgaa gttttgattt atttgtaata tattctacta
    38281 ctattataat ttttctactg gatatactaa tcatttgttt aacattatct gagattgatt
    38341 tgcaaacttt tatataacta aattagttat ataacttata gattccatta aataccctaa
    38401 taatcatata tgtacataca aagtcatgct tatgcaaaat ctgcagtttc aactaactta
    38461 ttatataaac catctttatg tagaagttca gcatcatttc cagattctat tactctacct
    38521 ttatctaata catatatatt atcagcactc ttaattgttg aaagtctatg agctattata
    38581 ataactatct tatcttgtat gtactctttc aagttgttca atatctcttt ttgtgaaata
    38641 ttatctagag ctgaagttgc ttcgtccaga ataagtacct ttttattact tactaaagct
    38701 ctagctattg atatacgttg tttttgacct cctgatattt tgacaccttt ttctcctact
    38761 acttcgtcca atcccttatc tagatttttt ataaaatcat ctaaacaagt aacttctaat
    38821 atctcatcta attctttatc acttatttta ttatttaata ctatattatt ttttattgtg
    38881 tcatcaaata caaattgatc ttgagttact atatcaatat tatttcttag tgattttaaa
    38941 ttaatatcct ttatattaac accatctatt aatatatcac cttcatttat atcccaaagt
    39001 cggtatatta gatttgttat tgttgatttg ccacatccac ttccaccaac aattcctgtt
    39061 acttcccctt tctcaaattg taaatttata tcatttaaaa caaggtttaa atcctcacca
    39121 tatctaaaag atacattttt aaaatctatt ttcttaattt cactgttatc tattctatat
    39181 ccattattat caactttaat atctatcttt tcatctatta ctgaaaatac tctattgata
    39241 gacacttttg attgtgctat tctagtattc gcccttacta tagctataca tggtccaatt
    39301 aacattcctg tatattgttg aaatgctatt aactccccca tcgtcatctt attatttatt
    39361 attttatatc ccccaattcc atatattaat attgttatca atcctgttag tatttgagat
    39421 attgctatat tactactcat aatgatgttc aaattcaaat ctttttttat caaatctctc
    39481 tctctcttta aatacttatt aaagaaattc ttttttgaat ttaatataac aatatccata
    39541 atattagata cgtactcttg aatcaaattt gataaactgc ctgaatcact tcttatttca
    39601 gaaattttct tagatataag ttttgtcatt ttattttgag aaaatgttaa tatcaactgt
    39661 aaaaataaaa ctactaaaaa taaatcaaac tgcaaattaa ttaagaaaat taacgatatt
    39721 atagctgtaa acacatttac aataatatca aatataatct ctgctccaaa gttttctatc
    39781 ataaatatat cactttccat aatggataaa atattacctg ttttcttact tgaataatat
    39841 ctaccagaaa gttttgatat atggttaagc aactttactt ttagatttat agtaacttta
    39901 ttttttattg aagtatataa atatgataat ataacatcaa atgtagctga taatatcctt
    39961 ataaaaatat atatcaatat taaatttata agcagaaaaa tatttttatt tcctattcca
    40021 tcatctatta tacatctaat tagttgaggt attacaatat ttacgccagc aattataaaa
    40081 accattataa atgatactat caacttagtc ttattcttat atactattat atttagtatt
    40141 ctaaataaat tattattaat agtttttttc atctattttt ccatctttta tagttataat
    40201 tctatcagct gtctttgcaa tattatcatt atgagttatc ataactagtg tttgtttgta
    40261 ctctttaaca caccattcaa gcatattcat aacttcattt gtagtcttac tatctaagtt
    40321 gccagtaggt tcatctgcaa atattactga cggtctattg gctaaagctc tagctattgc
    40381 aactctttgt tgttgacctc ctgatagttc attcggatat ttctttattt gtttttcaat
    40441 ccccaactta ttaattaatc tcataacata ttctttatct tcttttttcc catcaagcaa
    40501 cacaggaagt actatattat catatacatt tataactggt attaaattgt aactttgaaa
    40561 tatgaagcca aattcctgtc ttcttatttc agacagctta tcatcattta atgtatataa
    40621 atctacatca tctaagtaca cattccctaa agttggcttg tctaagcctg caacacagtg
    40681 aagtagtgta cttttaccag aaccacttgc acctacaata gctgtaaatt tatgtggctc
    40741 tatatctaaa tcaataccat caagagctct aacttcattc tcatattttc catatatttt
    40801 ttttaaatct tttaccttaa gtattttcat aacgtatctc cattcccatt taaaaaacat
    40861 atatttttaa attaaatttt cgtaaataag atctactgcc atatctaaat tctctaattg
    40921 atataagtat acttctttgt agtcaatact aatattaaac tctttattta aaatagttaa
    40981 aaaattatat gcattataat ttccaataca tgtaaaattg ttaaataaag aatattcact
    41041 tacaaattca aagtctattt ttattttaga aaagtttcta tttatcacat ttattatttt
    41101 ccttgctata tccaatctta tcaaattaga tttataactt ggagtgttca agttttctat
    41161 ttttaaatct tctttacttt tgcttttttg aataagtatt tcttccaatt cattaaactt
    41221 aatatatgga ttgtttttta atatatttgc aacaatgcca gttgccactg cacaagcctt
    41281 actattttta ccaaaatgag ttactttatc tttaaattta ataaaattat cttttgaatt
    41341 tgcatacatt tgaatcttat tttctggttc gtatatatat tgattatttt tatatatatt
    41401 ttcattacct actacaccaa taacactttc aaatatagta ggaatacttt ctttatcttc
    41461 atatttatta tgttttgaac aaataataaa tctaccttga ctatttaaaa tattacaaac
    41521 cttttctaat tctttttcat acatactatt aatagatgca gctgaaatgt ttattatctg
    41581 tatatccgac atagtcaact tgctcagtgt actaagaaga tttaaagaac ttgtttttcc
    41641 agaatcatta aatatattaa taggataaat ttgggtattt ttacttatat ttaatatggt
    41701 tttcgataca aaagttccat gtccatttat gtcatttatt tccttccccc ccaaatcttt
    41761 caattgaaaa tttgaatcat aaacataatt tccattaata tcatcatcat ttacatctaa
    41821 tcctgtgtct aagactgcta ttcttacttt agtcaattaa taatcacctc taaaataaat
    41881 taccttgaat ataaaactaa tccttaccat aatataggtt ccaagatgtt tttcattttt
    41941 ttacaatttg catcaaacat ttttttgtta ttttttaaag tatatatttt cgatggacaa
    42001 gttgtacaaa ataaatttac tttacattct ttacaactct caatatttac tggttttaat
    42061 ttatcaaata tattaaatat atccatttct ctattaagaa tcctctctaa tatgttttca
    42121 ttaaattcta atatattgaa tatctttaaa tccttatact ctaagtttgg acacggatat
    42181 acatctcctt tatgatctat acttatctga ttaacacctg ctttacacat atttgaacat
    42241 aaactacttt catccacata atcatctttg caaatgtaat caatatcaag tttatcatta
    42301 agatatttgc tatagttctc attacctcta ccaatattca taaaatttct tattataggc
    42361 gttgtaccta aatcttcatt taatttattg aatttctcta tgtctttctc attattcttt
    42421 cctaccacca tagacaaacc tacgttctcg aattttttta gttttataag tctaatcaca
    42481 tttaatactt tacagaatac tcctttacct cttacttcac tacaacttaa ttcatcataa
    42541 ccatctaaac taatttctat tgcatataaa ccattaatta tatcatcaat ctgtttttct
    42601 ttaattaaag ttgcatttgt agacagaatt attttacctt taaatttttc ttttatataa
    42661 tccaacagct ctaagaaatc atttctcatc aatggctctc cacctgtaat ggttaatatc
    42721 cttggattta atttaactat attatctatt acttttctta cttgagatgt atctaaataa
    42781 tcgttattat ctattttaga atctacacag caataatcac aacttagatt acatctatta
    42841 gttggagaaa atgaaatttt gtttattctc tctagtctaa attcacttag aatagaatca
    42901 cttagaagtc ctatatgctc taacttatct ataactcgtt cataatattt tttatcttca
    42961 ttttcttgga atacatcata caaattacca agttgtaatg cattatctac tgaatacttt
    43021 agaacttcat aacattctat tggaatttta acccatcttc catttacttt attactaaga
    43081 ataacttgat tattatttat tattttttca catatacaat ctaaaaaata tttgtttgag
    43141 ctattcattt attttatttc cttcctatat atttaaatta gaaatttcat taattttctt
    43201 ttataccact tactatacta agtttattta tcattttatt agaaaaataa actgcaatga
    43261 cacaaacaaa aacagatata gatccaaata ttagaatttc atatattgga atttcaaatt
    43321 taatagagtt atttatacca tatacctgtt gattaagttt gttagtttca gaaactattt
    43381 tataataatt gaaactagat ataattccag ctacaatcat acttaatacc ccatatatca
    43441 tattttcttt tattaacatt ctttttacat tttttttgga catccctatt gctctaaatg
    43501 tacatatctc actcaacctc acaattatat ttgatctaac tataaaaata atgtttatag
    43561 atgatattaa taaaactcca aatacacaaa tcattgctaa tttatatgag gatttattat
    43621 aatggtctcc aaaatgatta cgtacatatc ttccctctat atctgaaaat ccactttttt
    43681 ctattatatt atttatttct tttattactt ttttatctgt ttcttttttt atcttcacaa
    43741 aaactttatt ataatcactt atccctgtta attcttttaa atccttttca ttaaatataa
    43801 tttgaattcc acctgattga gattctccat cttgctctga tatatagcta tttttcatta
    43861 ttccagcgat tcttactttt gtatttatat atttatactc tccatcttta tatacaggaa
    43921 tttttatatc tattaagtct cctattttag gtgattttat aatctgagta ttatttgaca
    43981 atttaattct agaataaaaa ttatttacca ataaaacatt tt
//
LOCUS       DAEHWM010000025        44010 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.026, whole genome shotgun sequence.
ACCESSION   DAEHWM010000025 DAEHWM010000000
VERSION     DAEHWM010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 44010)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44010)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44010
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.026"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            22..555
                     /locus_tag="KNP36_001422"
     CDS             22..555
                     /locus_tag="KNP36_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor"
                     /protein_id="HBF0873304.1"
                     /translation="MTEVIIVNDARIISQIKAGKKELFDTLIKKYYDSIYCYCYRHVD
                     NKMTAQDLTQDVFVTVINNIENYKHYGKFENYLYVIAKNKCKDFWKKKQPIYLESLDK
                     EISNQELSDIENKMFIKEALTKLPELEFEVIILRYYHDLRFKDIAKIMESSVSVTKYR
                     MSRALKKLELYLEGGKL"
     gene            552..1313
                     /locus_tag="KNP36_001423"
     CDS             552..1313
                     /locus_tag="KNP36_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873305.1"
                     /translation="MNNKEIKRSLQKYKVPKYDSSALEKTIKTIHELTLSNTYKRMNN
                     KDFFISQIGFIRKRTWIMQFLILCTICIFLFSTSADSNSFYNSLSLISIASPLFVLTN
                     IEELTKVYNSSILEIEFSTKNTLHKIIATRMLIFGISDLLFMIIILVSAKQIIDVNIL
                     YIIIYILVPFNLMCIGCMEIINRNKGKHTNYYCMIYGISLVLLIVTLSNFRDNLYQFE
                     AINQWLIVFLVTAVTLIYEIRKTWRHLCSFENIII"
     gene            1351..2217
                     /locus_tag="KNP36_001424"
     CDS             1351..2217
                     /locus_tag="KNP36_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873306.1"
                     /translation="MELSVERLTKQYNNKIIVDKIDFKLNEGIYGFLGENGAGKTTLM
                     RMICGILSPTSGEVKVDGKNNLDMGEDFRDMIGYLPQNFGYYPDFTAKEFMLYIASLK
                     GLMPSYAKRKTQELLEMVGLSEVINKKIRTFSGGMKQRLGFAQTLLNDPKILILDEPT
                     AGLDPKERVRFRNLISEFSKEKIVILSTHIVSDVEYIADKILIMKKGRFVLTGSIEEV
                     TSKIKDKVWKCVVNENEIDYMSDRYCLANIHHSGGVANLRIVSDIKPHDNACNLKPTL
                     EDLYLYCFNEVL"
     gene            2238..3479
                     /locus_tag="KNP36_001425"
     CDS             2238..3479
                     /locus_tag="KNP36_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873307.1"
                     /translation="MSTLIKFELKKIIKRKSTIAVILGSLFLSIILFALMPIQEKAND
                     ESGKEYRGLQAIELKKQQSKLNEGYITDKKVKNSIRDYQKMFNNPNNITTDEGGFSNF
                     KPDIYWKFFYPNKAFYNFIIESYSNPNDYNPEIIKSMPLEDGVNFYKFRNEKVNTILN
                     MEYPDKNYTQKEKDFWLSKNKDIEEPYLNGYYQGWNYFLLARDLLIFTIVAVCISTAS
                     VFSGEYQSGADSIILSSKYGKTKVITAKIVSSFLFGTIIFTINTIVSIGILLLSFGID
                     GWNLPLQLTTSSIPYPYTFLQAILLSVLIIYMILILLISFTLLLSSYMKSPFPVLITN
                     IILLFVPIFLKYSETNKLYNQILNVLPSNAISFSFTNYVDYKFGNLIIALPTMIIFTC
                     LVLTVVFLPFIKNNFKKHQVN"
     gene            complement(3703..4275)
                     /locus_tag="KNP36_001426"
     CDS             complement(3703..4275)
                     /locus_tag="KNP36_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0873308.1"
                     /translation="MFKKIVAIASSIIVSTICLTGCDFNSNDKKGESSSSKNLDKVTI
                     AEVTHSVFYAPQYAAITKGFFEDEGIKIDLINTQGADKTMAALISGEANVGLMGPEAS
                     IYVYNQNKNDYAVNFAQLTKRDGSFLVARKKMPNFSYNDLKGTEILGGRKGGVPLMTF
                     EYVLKEKGLTIGENLKAGNVNVRTDVQKSV"
     gene            4661..5395
                     /locus_tag="KNP36_001427"
     CDS             4661..5395
                     /locus_tag="KNP36_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBF0873309.1"
                     /translation="MKQNKYDDDRFFNKYSKMERSTNGLAGAGEWHVLKKMLPDFKGK
                     RVLDLGCGFGWHCQYAVENGAISAVGVDISEKMLKEARNKTQLDNINYICMPIEDINF
                     PKDSFDVVISSLAFHYIQSFEDICKNISNCLSNKGNFVFSVEHPIFTAYGSQEWYCDK
                     DGTNLHWPVDGYFEEGVRKSNFLGEEVIKYHKTLTTYLNTLMKTGFEILEIIEPQPEE
                     KLLDTIPDMKDELRRPMMLLVSAKKR"
     gene            complement(5538..6029)
                     /locus_tag="KNP36_001428"
     CDS             complement(5538..6029)
                     /locus_tag="KNP36_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolyl-tRNA synthetase associated
                     domain-containing protein"
                     /protein_id="HBF0873310.1"
                     /translation="MNNQQQEVYKKLDELSIPYEAVNHPPVYTIEEMEELKTLHMEFV
                     VKNLFLRDAKGKEHFLVVLGKDKKADLKDIRQQIDSKPLSFASEERLQKYLKLTKGAV
                     TPFGILNDKEAVVKVVFDKDLLKMDKIGIHPNDNTATVFLKFEDMKKLIEENGNEIYY
                     VEV"
     gene            6378..6761
                     /locus_tag="KNP36_001429"
     CDS             6378..6761
                     /locus_tag="KNP36_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873311.1"
                     /translation="MSTDKVVGIIDEETAELAGIEYTGKIYASSGVIKHIKKKHRCQL
                     SKDIFNDIIDTIKMVLKSPEYIGSHPKKPGKSVEFIKKIDDYILVATELDTKKGYLYV
                     SSMYAIKEAKLESRVNSGRVKQYNG"
     gene            7269..7652
                     /locus_tag="KNP36_001430"
     CDS             7269..7652
                     /locus_tag="KNP36_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HBF0873312.1"
                     /translation="MNLSKKIEDKRKAKQRAEKVKKAKIATAGVVLGAVTGAVSGVLL
                     APKSGKETREDIKDASQQIAEKINMKTVDVKGKVSEKLEDKKGNFIESKKKIKKYIDN
                     KKSVENSSEEDKIIDIVEPVSVTEE"
     gene            7654..8004
                     /locus_tag="KNP36_001431"
     CDS             7654..8004
                     /locus_tag="KNP36_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873313.1"
                     /translation="MDNTITINISIIYVLLAILACIALVYLIIVLVKLHKILNNVGTM
                     LNENTQNINTTLNNLPNVVETFGEVGENMKDVTEVVTEVTADFLVTKDSVKSNMDVIV
                     DILTIIKNIFLDKK"
     gene            complement(8105..8563)
                     /locus_tag="KNP36_001432"
     CDS             complement(8105..8563)
                     /locus_tag="KNP36_001432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873314.1"
                     /translation="MIRTKVVELIATVCRENKPHKWVDENYTPYDKSGKVELMSIEDL
                     NELISSSGRADFLYSSRLQKLLEEVYINQSRASYISGCGLFWSSYWDILEEKFEEWLY
                     NSYIFFDEDDEYLEGMEDFELECKDVLMDVIETTSIDIYVQMIKRNITNY"
     gene            complement(8608..9396)
                     /locus_tag="KNP36_001433"
     CDS             complement(8608..9396)
                     /locus_tag="KNP36_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0873315.1"
                     /translation="MKVVIIPGHTLIGKGTGAVGYINESKETRILNDLIVKWLKIGGA
                     TVYTGRVDESSNHLADQCAIANKQETDLAVQIHFNSNATTSTPVGTETIYKTNNGKTY
                     AERVNTRLATVFKDRGAKSDVRGLYWLNHTIAPAILIEVCFVDSKADTDYYVNNKDKV
                     AKLIAEGILNKSISNSQEGGENKVYENVIVYTGDADKVAAQILHWQLKDSLIIEASSY
                     KQGLGKKVYVVGGEANKLVKGDVVINGADRYETVKLALQEIDKL"
     gene            complement(9535..9972)
                     /locus_tag="KNP36_001434"
     CDS             complement(9535..9972)
                     /locus_tag="KNP36_001434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HBF0873316.1"
                     /translation="MNKKLENRCSWQEYFMRLCETVAERGTCDRAYVGAIIVNSENRI
                     VSTGYNGSISGDKHCSEVGHEMRDGHCIRTIHAEQNALYYCAKEGISVKNCSIYVTHF
                     PCLNCTKAIIQAGIKHIYYRTGYRIDEYAIKLLQSSNVLYTKL"
     gene            10794..11303
                     /locus_tag="KNP36_001435"
     CDS             10794..11303
                     /locus_tag="KNP36_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873317.1"
                     /translation="MLSENIKTIRKSKGLSQQELAIKLNVVRQTISKWEQGLSVPDSD
                     MLISISEVLETPVSTLLGETIVESEVDNLKVISEKLEIINLQLAQRKNMRRKMFHWLF
                     ILLCAVILIVFVVLGGLNSPYLDWNYTDPETAVFGVAFHAFEWLFVRLVPIVLIGAII
                     GIFLTRKKI"
     gene            11709..12245
                     /locus_tag="KNP36_001436"
     CDS             11709..12245
                     /locus_tag="KNP36_001436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HBF0873318.1"
                     /translation="MQGGVNIRQVKSFVFPVISLIFLDQISKVLIGLFLMDFEIDIIG
                     KFLRFNPVQNTNLSYGGNFIGILSNLWVLVLFNILVILVIISGYAFYKSKNEQTSYSV
                     KVIMSCGLAGTICSLIDKLFWGGSLDFLQIPSFFIFDLKDCYLTVAEIIFVVIGILHN
                     REISMKEYIYFCYRQFKK"
     gene            complement(12672..13472)
                     /locus_tag="KNP36_001437"
     CDS             complement(12672..13472)
                     /locus_tag="KNP36_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873319.1"
                     /translation="MRLNKRSEGYINYVKGVKREKRNVLFYQLLILIGFIVIWELLAD
                     LNVINTFLFSKPSDIYNLFIQYAFSGQLFKHIGISVYETVLGLVIGTVLGILVAIALW
                     WSEKLSKILDPFLVVLNALPKTALAPIIIVWVGAGIEGIVVTAVTISVVVTILSAYNY
                     FMNIDEEKIKMLKSFGATKSQILFKLILPANTGNLINLTKINIGMAWVGVIVGEFLVS
                     RYGIGYLIVYGSQVFKLDLVMMGVFVLAICAWAMYAVVNIIEKIYNSR"
     gene            complement(13667..15265)
                     /locus_tag="KNP36_001438"
     CDS             complement(13667..15265)
                     /locus_tag="KNP36_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBF0873320.1"
                     /translation="MKAAIYSRKSRFTGKGDSIENQIQLCIDYAKSIGVKDFLIYEDE
                     GFSGSNIDRPQFKKMMQDAKDKKFSYLVCYRLDRISRNVSDFSTLIEKLNELSISFIS
                     IKEQFDTSTPMGRAMMFISSVFAQLERETIAERIKDNMYELARSGRWLGGNTPHGFNS
                     EKITFLDENLKERSMYKLQVNDEQMEIVKLIYNKYLELRSLSKLYKYVYNNGIRGPRG
                     GKFDPSSLSRILRNPAYVKANDEILDYLKNSGMDVVGTPDRKCGILTYAKNTSNSIAA
                     IAKHHGVIEPEIWLEVQNQLDKNRDKTPRISTGKTALLSGLIKCGKCGSNMRITYKGK
                     KTDKDLKYYYICGTKKTLGSDSCNCKNLNGPLVESLVIDKIKNCKEESIISAFNSNNI
                     KTDNVFNIFKSETNLLKNQILDKERLIKNLVIELAKNTGSTASDYIVSQIESLNNEIS
                     ILKDKINTLESSNINISSDSINIDIIVSNLKRFNDEVDNASLDDKRLLLSTIINSIVW
                     DSSLGNLNIVYMGAEVDNSVSLSN"
     gene            15593..15769
                     /locus_tag="KNP36_001439"
     CDS             15593..15769
                     /locus_tag="KNP36_001439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873321.1"
                     /translation="MEINVIEIFPKDKAKLNKIEMDKASWFVNIISKKYPKEALNEAF
                     STLEKELNISKANT"
     gene            15943..17073
                     /locus_tag="KNP36_001440"
     CDS             15943..17073
                     /locus_tag="KNP36_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBF0873322.1"
                     /translation="MNNFEIKTRIKFGEGSLKALQELKNKNVLIITDPFMVKSKTIDK
                     ITSNLINSTYQVFEEIVPDPPIEVVVAGIEAFKSINPDVIIALGGGSAIDAAKSIMDF
                     SKKILKINEVEFIAIPTTSGTGSEVTSFAVITDSQKKCKYPLVSDDLLPDMAILDPEL
                     VKTVPNFITADTGMDVLTHAIEAYVSTNSNDFSDALAEKAIKLVFKYLIKAYKDGNDI
                     EAREKMHNASCLAGMAFNQASLGINHSIAHVLGGKFHIPHGRTNSILLPHVIEYNSSI
                     VGYTNTTYSATAKKYAQIAELVGLGSANIRISVRNLVNEIKKLQKEMNMPTKLTQCKL
                     SLEDITNEEREIAKLAIKDTCTLTNPKVPTEDDIINILKNIK"
     gene            17314..17664
                     /locus_tag="KNP36_001441"
     CDS             17314..17664
                     /locus_tag="KNP36_001441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003453843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBF0873323.1"
                     /translation="MTEESKQRVIQEYVPGKQVTLAHIIANPNEDIYKKLGLVLDKKD
                     AIGILTITPSEASIIAADVATKASNVSLGFIDRFSGSVVISGDVSSVESALNDVLEVL
                     GNMLNFSSTKITRT"
     gene            17672..18121
                     /locus_tag="KNP36_001442"
     CDS             17672..18121
                     /locus_tag="KNP36_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EutP/PduV family microcompartment system
                     protein"
                     /protein_id="HBF0873324.1"
                     /translation="MKNIIFMGKTGSGKTTLCQKLDQLELKYKKTQSVELYNNAIDTP
                     GEYMENRNLYNALITTSADAKIIAIVYDATQEENYIAPGFASMFCKDVIGIITKINKA
                     TENEVNIAYERLSLAGASQIFKIDTVDNIGLEKLFKYLEKYKNIDEV"
     gene            18223..18798
                     /locus_tag="KNP36_001443"
     CDS             18223..18798
                     /locus_tag="KNP36_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBF0873325.1"
                     /translation="MGKKILLVDDEPLLRMDTKDILESHGYEIIGEASDGFEAVEMCK
                     KHKPDLVIMDIEMPILDGIKAGKIICKENIAGGVLLLTSFEDKEYVEKAKSIGAYGYL
                     VKTASEKSLIPTIEMCLNKVNEFEKMKKDLEKVNSKLNERKLVERAKGILIREFKISE
                     DEAYTRIRKLSMDKRTTMMEIAKMIIIGYDD"
     gene            18791..20200
                     /locus_tag="KNP36_001444"
     CDS             18791..20200
                     /locus_tag="KNP36_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase N-terminal domain-containing
                     protein"
                     /protein_id="HBF0873326.1"
                     /translation="MTNTIKKISTAQTYLNNNEIEKIIEVSKSLDLMASFYEADVFID
                     VLSKFDDEAIVVAHGRPKEKSMYCENVIGKKALIENEPGVIKCLKTGERVRDIKALTQ
                     EYKLVKQNIQPITLDDKVLAVLIVEKDISSEVKNEFNASEDEENKNLHQFIKLIGNND
                     FLVDNLNSAILIFDKNGKLKIKNRIATEIYKNLGFGYDIQDMHYNDLDIETNTFENIL
                     MDENYDETNEVSIGNMFFKIKTIYIKDDEFKVCKIVQDISDLKRKEEELVLKTVAIRE
                     AHHRVKNNLHTVISIIKKQSRLSQNDEVKQCLDNIINRVFAILSTHYLLSKEVDNNIS
                     IREGINLLVSNIQGGYLFSKDIDIRITGEDFKISGEKATAILLVINEILQNCYDHAFS
                     DREHGTIQILINKDNDYRNIAIIDDGIGFDSNNINKNSLGTYIIDSYITQMLKGNIER
                     KSSENGTEVLITIPTQINI"
     gene            20384..21817
                     /gene="eutA"
                     /locus_tag="KNP36_001445"
     CDS             20384..21817
                     /gene="eutA"
                     /locus_tag="KNP36_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004458698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase reactivating factor
                     EutA"
                     /protein_id="HBF0873327.1"
                     /translation="MREELLSVGIDIGTSTTQLIFSKLIVENTESNFSVPRISIVDKE
                     IIYKSKVYFTPLISNNEINGQQIKDIVENEYKKANISKEDIHTGAVIITGETARKENA
                     NDVLHTLSGFAGDFVVATAGPDLESIISGKGAGAHIYSKEHSTTIVNIDIGGGTSNIA
                     SFKRGEVTDTGCLDIGGRLVKIDKISKKITYISPKIDKIIKDNNLNLQVGTMATVENT
                     KPIVDIMVDLLMESIGLKKQTPLFDFIITNKSISIDENIKNVSFSGGVADYIYYDGEI
                     KDYFEYGDLGILLGQAIKNCEYLKKVNVVKSMETIRATVVGAGSHTTEVSGSTITYTS
                     EKFPLKNLPVLKLSIDEETGTSKQISEAIKNKLNWFKLENDLQKVAIAMIGKKNPTFL
                     DIQEYAKGFVDGMQQIIENDLPFIVIVENDMAKVLGQAIYALLNYEKEIVCIDSVKVE
                     NGDYIDIGKPIVEGKVLPVVIKTLVFN"
     gene            21835..23199
                     /locus_tag="KNP36_001446"
     CDS             21835..23199
                     /locus_tag="KNP36_001446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase subunit EutB"
                     /protein_id="HBF0873328.1"
                     /translation="MILNTKLFGRTYQFKGLYDVMAKANEEKSGDKLAGLAAESAEER
                     IAAKVVLSHIKLEDIRNNPAVAYEEDEVTRIIQDAVNEKVYEEIKNWTVSELREWLLD
                     SNTTSLDIRRISRGLTSEMIAAVAKLMSNMDLVYAAKKIKVTAHCNTTIGEQGTLSAR
                     LQPNHPTDDPDGILASLLEGLTFGIGDAVLGLNPVDDSVESVTKVLKRFEEVKQKYQI
                     PTQTCVLAHVTTQMEAIRNGAPADLIFQSIAGSEKGNEAFGFNGDTIEEARQLALKHG
                     TATGPNVMYFETGQGSELSSEAHHGIDQVTMEARCYGFAKKYEPFLVNTVVGFIGPEY
                     LYDAREVVRAGLEDHFMGKLHGLPMGVDVCYTNHMKADQNDMENLAILLTTAGCTYFM
                     GIPHGDDVMLNYQTTGYHETASLREMFGLTAIKEFDAWMEKMGFSKDGKLTELAGDAS
                     VLLG"
     gene            23212..24093
                     /gene="eutC"
                     /locus_tag="KNP36_001447"
     CDS             23212..24093
                     /gene="eutC"
                     /locus_tag="KNP36_001447"
                     /EC_number="4.3.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014952556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine ammonia-lyase subunit EutC"
                     /protein_id="HBF0873329.1"
                     /translation="MNEKDLKALVEQLVGQMVGELDTNVVSETVKKATEVVVDNNACI
                     DDITEVDIRKQLLVKNPKDAEAYLDMKAKTPARLGIGRAGTRYKTETVLRFRADHAAA
                     QDAVFSYVDEEFIKENNMFAVETLCKDKDEYLTRPDLGRKFSPETINNIKSKFGTNQK
                     VLILVGDGLSSAAIEANLKDCVPAIKQGLKMYGIDSSEILFVKHCRVGAMDHLGEELG
                     CEVICMLVGERPGLVTAESMSAYIAYKPYIGMAEAKRTVISNIHKGGTTAVEAGAHIA
                     ELIKTMLDKKASGIDLK"
     gene            24113..24766
                     /gene="eutL"
                     /locus_tag="KNP36_001448"
     CDS             24113..24766
                     /gene="eutL"
                     /locus_tag="KNP36_001448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003761789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization microcompartment
                     protein EutL"
                     /protein_id="HBF0873330.1"
                     /translation="MKNDVIRPNILGIKIISNISPEMAQKLELKSHHKSLGLITADCD
                     DVTYTALDEATKASEVDVVYAKSMYAGAANASTKLAGEVLGIIAGPSPAEVRSGLNAV
                     VDFLEYGATFISANDDDSIAYYAHCVSRTGTYLSEVAGIREGEALAYLVAPPLEAMYA
                     LDAAMKAADVKMCELFAPPTETNFGGALLTGSQSACKAACDAFAEAVKSVADNPTGF"
     gene            24777..25478
                     /locus_tag="KNP36_001449"
     CDS             24777..25478
                     /locus_tag="KNP36_001449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBF0873331.1"
                     /translation="MDAIGLIEVIGYVAAIEASDACLKSANVNIVRVDKVGAGIVTLT
                     ICGDVGAVKAALEAGEIAASRVGTLRTSHIIPRIHNEVTNALFKTKEPKVCEVSEDKE
                     KNFEITLEIADNVSKNLSEKENVILDVNENSGDTENLYSDIDKTNKKIETVDDSLTEA
                     NEEKIENTNDKEVLEQVKIENSDFDRDDLSKNSVKKLKAMAKKLDSSITYKDLNVLKK
                     EELINLVKKLSRRDR"
     gene            25481..26950
                     /locus_tag="KNP36_001450"
     CDS             25481..26950
                     /locus_tag="KNP36_001450"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetaldehyde dehydrogenase (acetylating)"
                     /protein_id="HBF0873332.1"
                     /translation="MTLLDKDLVSIQEVRTLVRRSKVAQEKLSKMSQEQIDKIVKAVV
                     DAAFNNATKLAKMANEETGFGKWEDKVIKNTFASMGVYETLKNTKTIGIIGEDKEANT
                     IDIATPVGVVAGLIPSTNPTSTVIYKTIISLKAGNTIVFSPHPNAKNCILETVNIISD
                     AAIKAGAPEDSILCITNPSIVGTNELMKHKDTNLILATGGEAMVRAAYSSGTPAIGVG
                     PGNGPAFIDKSANVKLAIKRIIDSKTFDNGVICASEQSIVIEKSMEETVLKELKNQGA
                     YVLNEEESERLAKFILRANGTMNPQIVGKSVEVIANLADLTNVPKNTKVLVARENKVG
                     HNVAYSREKLTPILAFYVEENVEAIMNRCREILLNEGAGHTFSMHVNDEELVKRFALN
                     MPVSRILVNTPSALGGIGASTNLVPALTLGCGAIGGSSTSNNIGPLDLINVKRVAYGI
                     KEIEELGRDKSQVEKSMFDSMDKEELINLLVQKLVKELA"
     gene            27046..27333
                     /gene="eutM"
                     /locus_tag="KNP36_001451"
     CDS             27046..27333
                     /gene="eutM"
                     /locus_tag="KNP36_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization microcompartment
                     protein EutM"
                     /protein_id="HBF0873333.1"
                     /translation="MASANALGMIETKGLVGAIEAADAMVKAANVQLVGKEQVGGGLV
                     TVMVRGDVGAVKAATDAGAAAAERVGELISVHVIPRPHFEVDAILPKVSAE"
     gene            27460..28221
                     /locus_tag="KNP36_001452"
     CDS             27460..28221
                     /locus_tag="KNP36_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin adenosyltransferase"
                     /protein_id="HBF0873334.1"
                     /translation="MGVLTENEVKRKIGKNKNNITEFYIEKGQIITPSAKSYLAERSI
                     ELKYVDKLSDVNNEPKEVVKEVVKEKKYRYTTVFGAKLDEKPEHMTQLNGNLLVFKDH
                     KRIILRGKIDSLESEILKVQILCQKLDMPKLVKELQEVLDFVRNIMRCEVLDEKLGDF
                     KLLGLTPQELREQSHYPKKYFGIGHEFPSYEMGEVVVAINSIRSNTREVELAAYEAFK
                     GEYGNVHREDLIKALNRLSSVFWIMIYKVRTNKYK"
     gene            28234..28863
                     /locus_tag="KNP36_001453"
     CDS             28234..28863
                     /locus_tag="KNP36_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate propanoyltransferase"
                     /protein_id="HBF0873335.1"
                     /translation="MENLLNEIVEEVITRVKKEAFIEVEASGRHVHLSREDVDKLFGE
                     GYTLTKLKDLSQPGQYACKERVTITGPKGSIKNVVVLGPCRNETQVEISLTDGSTLGL
                     KAPIKQSGDLEGTLSIKISTQYGEVELDKGLMVAKRHIHMTPKDAEKFNVCDKEIVEA
                     KVMGQRPLTFDDVVIRVSDSFKTYMHIDYDEANACGYSKGTVAKIIKKA"
     gene            28905..29630
                     /locus_tag="KNP36_001454"
     CDS             28905..29630
                     /locus_tag="KNP36_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02536 family ethanolamine utilization
                     protein"
                     /protein_id="HBF0873336.1"
                     /translation="MNYDNLVDLITEEIYKKINSNEIKISNKPKAVIVFEQDNNKFNL
                     LKDEFEIVEFDKSIRECEIVIVSRLCMRGLSNIALGNSTSDEERFILKMIMKGKEVYV
                     LDEGIEYKKYKDTAPKALYKKFMSFEDEICKFGVEIIKDLNVITKNKLNIKKELESTR
                     GSKKEDTKVLDKDVLNLTSVESVKIDNEFSLDLRNKKLISEADLRKPTINGVKNILVN
                     KKSIITPLAVDFMRIHHLKLKKV"
     gene            29643..29915
                     /locus_tag="KNP36_001455"
     CDS             29643..29915
                     /locus_tag="KNP36_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EutN/CcmL family microcompartment protein"
                     /protein_id="HBF0873337.1"
                     /translation="MDIGKVVGNVWATRKDEKLCGQKLLVVKILKTKDTYKEGFMVAA
                     DNAGAGNGDLVLISKGSSARESIEKSHVPVDATIVGVVDSFEVFDE"
     gene            29908..30459
                     /locus_tag="KNP36_001456"
     CDS             29908..30459
                     /locus_tag="KNP36_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMC domain-containing protein"
                     /protein_id="HBF0873338.1"
                     /translation="MNKSIGAIEFKSIAKGIEVSNEMIKKSSVDVLYLKSICPGKFLI
                     IVGGETSYINECVDYGIKLGEGYIVDNFVINAISQEILDGFKNKYQKLDSIVSIGVVE
                     SSKVCAGIKMLDKTLKSGDLVLVKLQLSFAIGGKLVYIVAGDLSSLEYALKESENVVR
                     EKEVIYKTVIPSVDSQIIKSLIK"
     gene            30471..31562
                     /gene="eutH"
                     /locus_tag="KNP36_001457"
     CDS             30471..31562
                     /gene="eutH"
                     /locus_tag="KNP36_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethanolamine utilization protein EutH"
                     /protein_id="HBF0873339.1"
                     /translation="MSINEIIIYVMVVFMVLGAIDKCIGNKFGLGEQFEEGIMAMGSL
                     AVAMVGVICLAPVLADVLRPIVVPVFNILGADPAMFAGSLLANDMGGAPLALELAKDP
                     NAGLFGGLIVGAMMGPTIVFIIPVALGIIEKEDQKFLATGILAGIITIPIGAFVGGLV
                     AGFEVMMVLRNLVPIIIFAVVIALGLLKFENAMIKGFTYFGKGVVIVITLGLAAAIVE
                     ALTGIVVIPGMKPISEGIEIVGDIAIVLAGAFPLVFVITKVFNKPLMALGKVLGMNDV
                     SAAGLVASLANCIPMFGMMKDMDNRGKIINVAFSVSAAFVFGDHLGFTAGFNSNMITP
                     MIVAKLVGGITAVLLAMVIANKTLKKENV"
     gene            31564..32037
                     /locus_tag="KNP36_001458"
     CDS             31564..32037
                     /locus_tag="KNP36_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF861 domain-containing protein"
                     /protein_id="HBF0873340.1"
                     /translation="MDISNIDKNLIETLVRQIIEEKISGTKDTVDFVRNKDISGITSI
                     KLPTVKVSESDRLDTGNPSDVVYTKDLFTLEESPRLGCGMMEMKETTFDWTLNYDEID
                     YVIDGTLDIIIDGRKVSASSGELIFIPKGSKIQFSVPDYARFIYVTYPADWASQN"
     gene            complement(32157..32258)
                     /locus_tag="KNP36_001459"
                     /pseudo
     CDS             complement(32157..32258)
                     /locus_tag="KNP36_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433047.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
     gene            32553..33074
                     /locus_tag="KNP36_001460"
     CDS             32553..33074
                     /locus_tag="KNP36_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0873341.1"
                     /translation="MEEIVKKEQASMNDIFLYLKAKSNSLYKFVILYNEFINKPKDYG
                     TGELINMVEVHMLTAIEENPGISPTQLAKIWNRTKGAISQTISKLEKKGYITKEKKEG
                     NAKTILLYPTTSGVELSKAHKLYDTIDVTRTFEYLIKECTLEEIDSFYKVIDLFINLL
                     EESPQENNDSEKV"
     gene            33453..34628
                     /locus_tag="KNP36_001461"
     CDS             33453..34628
                     /locus_tag="KNP36_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0873342.1"
                     /translation="MNLKQLSEKYEEYVIQMRREFHKYPELSFKEIRTTQRIREELQK
                     IGVPFVSIEPNIVIATIQGKNEGKTIAIRGDIDALPMQEDSDVEYKSEYDGIMHSCGH
                     DAHGAMLLGLAHMLNDIRKDLKGRVLLVFQAAEEVGGGHKEIIQYFKENGGPDRLIAT
                     HVWSDIEAGKISVEPGPRMAGGSGWRIDITGRGGHGSRPDQSIDPIKPACDIVLKVSS
                     IPVNHISVLEQCVVHACAIHGGTTIGNVIPNNAEVIGGYRYFTEESGKKVFDIIKQMS
                     NGVGQVYGVDVKVTHTGGIGPVINDEEAVKMAKEIVSNIDGLELDSYEPICASDCYGE
                     ILKEYSGFYCYLGVGNKEKGIIYAQHHPKYNIDEDTLKLGCEFMAKYAVEFLNKNNN"
     gene            34663..36201
                     /locus_tag="KNP36_001462"
     CDS             34663..36201
                     /locus_tag="KNP36_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBF0873343.1"
                     /translation="MQGALKENKKKSGGGFLGWIEKVGNKMPHPLALFTYITLIVVAL
                     SAIASFLGFSATSPATGKLIKVMNLISAKGLVLFMQEFVKNFQNFPVLGVVLVMAVAT
                     GVCEKTGFFSTAIKMSLSKVKGNAVVFIIAFIGVFANQAGDAAFVLVPTLAGAIFYGL
                     NRNPLAGIFCGFASVGGGFATAVIPGGWDVTLTPITVSAAQTIQPAFDMTLLASYYAL
                     FVSAFIVATVSTIVTVKFIEPKLGKYTGKPEGIDDNQGFEVTKEQAKAAKLAGFTVLA
                     YVALLIALCIPANSFLRSPEGSLIFGAPLMSCLQFFIVILFFLPGIVYGMRVGKIKTV
                     KDLNDILCQSMAAMAPFIVLAIVIGQFLTLFSVSNLAQVLAIKGGALLNSLPLPPQAI
                     ILLFLVLVAFINIFVISGSTKWMIFGPVFVPMLMQLNIHPAFTQFVYRLGDSVTNHLS
                     PLNAFFIILLATVQKYDKNAGMGTIFSAMIPYTIGYFVVLAVLVVVWMTIGIPVGIGG
                     QVWL"
     gene            36233..37435
                     /locus_tag="KNP36_001463"
     CDS             36233..37435
                     /locus_tag="KNP36_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0873344.1"
                     /translation="METTEIRYNFDEVIDRSGTNCLKYDLKSQFMPESPEDALPLWVA
                     DMDFACAPEIINAMHERIDRKIFGYSSQQTDDYYEAVCGWFKRRFDWKIEKENIFFSP
                     GVVPALGFFTQILTQKGDGIIIEKPVYYPFEDKITNNERKVVNSPLKFEDGHYSMDYD
                     GFEELAKDENNKVFILCSPHNPVGRVWKKEELRKIVDICKKYDLWIISDEIHCDIIRK
                     GEKHIPLEVACPDYKDRIITCTAPSKSFNLAGMQLSNIVINNKELQKKWMLETDSKLA
                     IFLPNPFAIVATKVAYNDCEDWMNQVNEYIDGNIKYVEDFVNEYMPKVKIIKSQGTYL
                     VWLDFRGYGLDAKQLEYVMLNKAKVLLDEGYIFGEEGAGFERINVASPRTIIEECMNR
                     IKCAFEGL"
     gene            complement(37602..38201)
                     /locus_tag="KNP36_001464"
     CDS             complement(37602..38201)
                     /locus_tag="KNP36_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0873345.1"
                     /translation="MNDNIVEVKNINMNFYTKEGELEVLKDVNFNLKEGEILTLLGPS
                     GSGKSTILNILTNLLKPTSGDIKITGNIGYMFQKDNLLEWRNIMDNITIGLEIQGKKD
                     KKSLDRVESLLKTYGLWDFRSMYPKELSGGMRQRVALIRTLSVNPDILLLDEPFSALD
                     YQTRLLVCDDVYSIIKNENKSTILVTHDIGEARCIKVQL"
     gene            38371..39729
                     /locus_tag="KNP36_001465"
     CDS             38371..39729
                     /locus_tag="KNP36_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873346.1"
                     /translation="MSNIITNLIESIFTNPITILFLLAITVYSVFKIIENNRVYSFVS
                     SKLDEINRDYKTSEFYKKVRDDYYTYSKENPYADVNITSFIEEVVSDLKHNNLPLLEK
                     IRSIKNSSSISILLGVLGTFVGLSTMLLCVDTKDIINSLPSTISSMQTAFTTSIFGVV
                     FSLIIGYFTKIKDCEHVLIQIMLKSENLLTSEITHFKSERMDLKVEEVKNTIKQISKS
                     IEAIEKFDKISKDLNDFNDEFISGIEALKSLLEGSQSSIKTFDQSVRKLDKQFNILNI
                     KFVKLFDKYDNQDNINKEILFDIKESSKNIYNATESQFKIRDYIKNINAGFALYERSA
                     QDLLTKLMTHENKISQNQKILLDEKFTLDDSIKNLSSIIENFSNDLQVKLDMMFENSL
                     DIQDKLDVMFNNSFMNDEVPLDSEELFKDDVNNVFNPFSEEIYEIEDKEIKVIGEDEL
                     NE"
     gene            39722..40354
                     /locus_tag="KNP36_001466"
     CDS             39722..40354
                     /locus_tag="KNP36_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA family protein"
                     /protein_id="HBF0873347.1"
                     /translation="MNNKYRRTVNREFEKSSFWPTFTDLLSTVLMVVILILFSSESIS
                     GSVEQDLAKNVNASVEETFKKSGIPVKVDKSNGQVTFGEKTMFDVDSDVLKPEAKEML
                     KMFVPKYIETIYKDYGDYISKIVIEGHTDDVGSYIYNLDLSQRRAYSVAKFIVGDEIG
                     DYKYKDKVTKHIIAIGRSKAELIKNGDNSVNRDASRRVELKYEININQNK"
     gene            40683..41840
                     /locus_tag="KNP36_001467"
     CDS             40683..41840
                     /locus_tag="KNP36_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0873348.1"
                     /translation="MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNN
                     NDSLSSSISSDKNVKIHFIDTGNSDAILIQDGKTFTLIDGGDNDDEGLMVDYLNNQGV
                     KDIKYLIATHSHADHLGGLDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPS
                     VPLENNKFYLEDSYFEVLNTNGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILP
                     KLEKVDLLKVAHHGSRSSSSQEFLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGV
                     KVHRSDECSDIIFESTGDGVFTSCKDGSYNKGVREDGNSGKSNSNTSKNDSFKNKQNT
                     SNSEEIVYFTPKGKSYHSTKNCSGLSRSKKILSGTIAESKKNDPCDICYGK"
     gene            complement(41987..42622)
                     /gene="lexA"
                     /locus_tag="KNP36_001468"
     CDS             complement(41987..42622)
                     /gene="lexA"
                     /locus_tag="KNP36_001468"
                     /EC_number="3.4.21.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor LexA"
                     /protein_id="HBF0873349.1"
                     /translation="MYLDLTEKQVLILEFIKSQIILKGYPPAVREICTAVGLRSTSTV
                     HSHLNKLEKLGYIRKDPTKPRAIEVLERSKVNDVSGANQEIIELPLVGQITAGEPILA
                     QQNIEEYIPFPASLVKGSNNFVLRVKGESMINAGILDEDYVVVDKKNTALNSQIVVAL
                     INGESATVKRFFKEGNLIRLQPENDFMEPIMLNDSEVEIVGIVTGVFRVIK"
     gene            complement(42726..43853)
                     /locus_tag="KNP36_001469"
     CDS             complement(42726..43853)
                     /locus_tag="KNP36_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBF0873350.1"
                     /translation="MNNDKKIIKVHNKSDKPDNIVIKENELIEKCLLLENKLPVFMKD
                     YFIYLKGSVAVSTRLAYLEDINFFCSYLIETKELTNADCVKDITEDDFNTIKSRDINL
                     FLGDYCSRYYKNTEKNTLIFENNNRALARKKSSISTLFKFLYRNSQIDNNITDGFNPI
                     KLPKPQPDAIKRLEIDEVAKMLESVETGEGLTEKEKVYWRKTKLRDKAILALFVTYGL
                     RLNELRELNISSFNFSRGEFKIYRKRGKEVLMPINHTCEHVIKDYLQNERTRDELLND
                     EEKDALFLSLQNKRITAKAIRTLVKKYTSIPLDTTRDNGYSPHKLRATAATSLIQTGF
                     SIYDVQNLLDHDNVTTTQLYAAHKKNVKRDIVKNFEWIEDD"
BASE COUNT        17060 a         5395 c         7112 g        14443 t
ORIGIN      
        1 tagtataaat cgttatatat aatgacggag gtgataatag tgaatgatgc tcggattata
       61 tcacaaataa aagcaggaaa aaaagaattg tttgatactc taataaaaaa atactatgat
      121 agcatctact gttattgtta tcgccatgta gacaataaaa tgactgcaca agatttaact
      181 caagatgtat ttgtaacagt tataaataat atagaaaatt ataaacatta tggtaagttt
      241 gaaaactatt tgtatgttat tgcaaaaaac aagtgtaagg atttttggaa gaaaaaacaa
      301 ccaatatatt tagagtcatt agataaggag atatcaaatc aagaattatc tgatatagaa
      361 aataaaatgt ttataaaaga agctttgact aaattaccag aattagaatt tgaagtgata
      421 attttacggt attaccatga tttaagattt aaggatattg ctaaaattat ggagtcaagc
      481 gtctctgtca caaagtacag gatgagtagg gcattaaaaa aactagaatt atatctggaa
      541 ggaggtaaat tatgaataat aaagaaataa aaagaagtct acagaagtat aaggttccca
      601 aatatgattc ttcagctctt gaaaagacta ttaaaactat acatgagtta acgcttagta
      661 atacttataa aagaatgaat aataaagact tttttatatc tcaaattggt tttataagaa
      721 aaagaacttg gattatgcaa tttctaatac tatgtacaat atgtatattt ttatttagta
      781 catcagcaga tagtaattca ttttataata gtttatcctt gatttctata gcatcaccac
      841 tttttgtact gacaaatata gaagaattaa caaaagtgta taatagtagt attttagaga
      901 tagaattttc aacaaaaaat acattacata aaattattgc tactagaatg cttatatttg
      961 gaataagtga tttattgttt atgattatta ttttggtatc tgcaaaacaa atcattgatg
     1021 taaacattct gtatataata atttatatac tagttccttt taacctaatg tgtataggat
     1081 gtatggaaat tataaataga aataaaggta agcatacaaa ttattattgt atgatatacg
     1141 gtatatctct tgtattatta atagttacac tgagtaactt tagagataat ctatatcaat
     1201 ttgaagcaat aaatcaatgg ctaattgttt ttctagtcac agcagtaaca ttaatatatg
     1261 aaataagaaa aacgtggaga catctttgtt catttgaaaa tattattatc taagtaaaaa
     1321 ataagaatac acagtatcag gaggaatagt atggagttaa gtgtagaacg tttaacaaaa
     1381 cagtataaca ataaaattat agtagataaa attgacttta aattaaatga gggtatatat
     1441 ggatttttag gagaaaatgg agctggaaaa acaactctta tgagaatgat ttgcggaata
     1501 ttaagtccta catctggaga agtaaaggtg gatggtaaaa ataatttgga tatgggagaa
     1561 gattttagag atatgattgg ataccttcct caaaactttg gatactaccc agattttact
     1621 gccaaagaat ttatgctata tatagcatca ttaaaaggat taatgcctag ctatgcaaag
     1681 agaaaaacac aagaattatt agaaatggta ggattatcag aggtaattaa taaaaaaata
     1741 agaacatttt ctggaggtat gaagcaaagg ctaggatttg ctcaaacact acttaatgac
     1801 cccaaaattt taatattaga tgagccaaca gcagggctag accctaaaga acgagttaga
     1861 tttcgcaacc taatttcaga attttctaag gaaaagattg ttatattgtc tactcatatt
     1921 gtgtctgatg tagaatatat tgcagataaa attttaataa tgaaaaaagg aagatttgtt
     1981 ttaactggct caatagaaga agtaacttca aagataaaag ataaggtatg gaaatgtgtg
     2041 gtcaatgaga atgaaataga ttatatgtct gatagatatt gtttagcaaa tatccatcat
     2101 tctggtggag ttgcaaatct tagaattgta agtgatataa agccacatga caatgcatgc
     2161 aatttaaaac caacattaga agatttatat ttatattgtt tcaacgaagt actataaata
     2221 tacataagga gataggtatg tctacattaa ttaaatttga gttaaaaaaa ataataaaaa
     2281 gaaagtctac aatagcagtt attttaggaa gtttattctt aagcatcatt ctttttgcat
     2341 taatgccaat tcaggaaaaa gctaatgatg aaagtggaaa agagtatagg ggtttacagg
     2401 ctattgagct aaaaaagcaa caatctaaat taaatgaggg atacataaca gataaaaaag
     2461 taaaaaactc aatcagagat taccaaaaaa tgtttaataa tccaaataat attacaacag
     2521 atgaaggtgg gttttcaaat tttaaaccag atatttattg gaaattcttc tatccaaata
     2581 aagcttttta taattttata atagagtcat atagtaatcc aaatgattat aatccagaaa
     2641 taattaaatc aatgccttta gaagatggag ttaattttta taaatttaga aatgaaaaag
     2701 taaatacaat attaaatatg gaatatcctg ataaaaatta cacacagaaa gagaaagatt
     2761 tttggttgtc taaaaataag gatatagaag agccttattt aaatggatat tatcaaggat
     2821 ggaattattt tctattggct agagatttac taatttttac tatagtagct gtctgcataa
     2881 gtacagcttc tgtattttca ggagaatacc aatccggtgc tgattcaata atattatctt
     2941 ctaaatatgg aaaaacaaaa gttataacag ctaaaatagt aagttccttt ttatttggta
     3001 cgattatttt tacaataaat acaattgtgt ctattggtat acttctttta tcttttggaa
     3061 ttgatggatg gaatttacca ttacaactta caaccagttc aattccatac ccatatacat
     3121 ttttacaggc aatattacta agtgtgttaa ttatttatat gatattaata ctattaatta
     3181 gttttacact tttattatca tcttatatga aatcaccttt tccagtttta attacaaata
     3241 taatattact atttgtacca atatttttaa aatatagtga aacaaataag ttgtataatc
     3301 aaattctcaa tgttttacca tcaaatgcta tttcattttc atttactaat tatgtagatt
     3361 ataaatttgg taatttaata atagctttac ctacaatgat tatttttaca tgcttagttc
     3421 ttacagttgt ttttttacct tttattaaaa ataattttaa aaaacatcaa gttaactaaa
     3481 atatatatta taaaaagaag gtgtcttaaa atgaactttt tagcttatta ggcactcttc
     3541 tttgtattaa tttaaatata ttttagtatt agattaaata tgttttcatc attttaacaa
     3601 tgaaaaagag ctttatctct attttgagat agctcttata aagttaaata ttaaattgat
     3661 aactataaaa tatgtagttt gaatttataa tttgtgttat aatcatactg atttttgtac
     3721 atcagttctt acattaacat tgcctgcttt tagattttct ccaatagtaa gacctttttc
     3781 ttttagaaca tattcaaaag tcattagtgg aactccacct tttctaccac ctaatatttc
     3841 ggttcctttt aaatcattgt aagagaaatt aggcattttt ttcctagcaa ctagaaaact
     3901 accatctctt tttgtcaatt gagcaaagtt cactgcataa tcgtttttgt tttgattata
     3961 tacatatata gatgcttcag gacccattaa acctacgttt gcttcacctg aaatcaaagc
     4021 tgccatagtt ttatctgcac cttgggtatt tataaggtca atctttatac cttcatcttc
     4081 aaagaatcct ttcgtaatag cagcatactg tggagcataa aaaacagagt gagtaacttc
     4141 tgctatagtt actttatcca gatttttaga cgaagaagat tcaccttttt tgtcattaga
     4201 gttaaaatca catccagtta gacatattgt acttacaatg atagagcttg ctattgcgac
     4261 tattttttta aacataataa atacctccca taagacatac gaatagtata tagtattaaa
     4321 aatttattgt agttgttaca aaaatgtatc tatgcttata atatttctac aaaaacttaa
     4381 taataatttt cagctttatg tttagttttt tcagtaatgt gtaatattgg ataaattata
     4441 ttgattattt ataaactaag taataaaatt aaaataatat cacttttttg tctattatat
     4501 ataaggaaaa attttttaat aatataaatc atattcattt atattattaa aaaatttgtt
     4561 tatagaaact tttattattt tatataaaag tgataaaaac ttatattttg tatttaatag
     4621 agtgttgcta agtgaatata tttaaaatgg aggaaacttt atgaaacaaa ataaatatga
     4681 tgatgataga ttttttaata aatacagtaa aatggaacgt tctacaaatg gattagcagg
     4741 tgctggagag tggcatgttt taaaaaaaat gttacctgat ttcaaaggaa aaagagtttt
     4801 agatttagga tgtggatttg gatggcattg tcaatatgca gttgagaatg gagcaatttc
     4861 tgctgttgga gttgatattt cagaaaaaat gttaaaagaa gctagaaaca aaacgcaact
     4921 tgataatata aattacatat gtatgcctat tgaagatatt aattttccaa aagatagttt
     4981 tgatgtagtt attagttcct tggcatttca ttatattcaa tcatttgaag atatatgtaa
     5041 gaatataagt aattgtcttt caaataaagg taattttgta ttttctgttg aacatcctat
     5101 atttactgca tatggaagtc aagagtggta ctgtgataaa gatggcacta atctacactg
     5161 gccagtagat ggatattttg aagaaggagt acgtaagtca aattttctag gagaagaggt
     5221 tataaaatat cataaaacat taacaactta tttaaatacg ttaatgaaaa caggatttga
     5281 aatattagaa attattgaac ctcaaccaga agaaaaactg ttagatacaa ttcctgatat
     5341 gaaagatgag ctacgtagac ctatgatgtt acttgtatct gcaaaaaaaa gataagtaaa
     5401 tataaataat cattattgta gaaaaaaagt tgtagaaaat aattacacta atggagatga
     5461 ttataccagt ggtattaatt acaccagtag taaggaggca aaagcattcg ttgcttttgc
     5521 cattttttaa gttgcaatta tacttctacg tagtatattt cgtttccatt ttcttctata
     5581 agctttttca tatcttcaaa ttttaaaaat acagtagcag tattatcatt tggatgtata
     5641 cctattttat ccatttttaa taaatcttta tcaaatacaa cttttacaac agcctcttta
     5701 tcatttaata taccaaaagg agtcacagct cctttagtaa gtttcaagta tttttgaagt
     5761 ctttcttccg atgcaaaact aagaggttta ctatcaattt gttgacgaat atcttttaaa
     5821 tctgcttttt tgtctttacc taatacaact aaaaaatgtt cttttccttt agcatcacga
     5881 agaaataggt tttttacaac aaattccata tgtaatgttt ttaattcttc catttcttca
     5941 attgtataaa ctggtggatg atttacagcc tcataaggta tgcttaactc atctaatttt
     6001 ttatatactt cctgttgttg attgttcatg atttcctccc attagaaatt tattttatat
     6061 ataaataata ttatcacaga aaactttaaa agaaaacgtt ttatataata tagacaatag
     6121 attatatttt tataaagaag caagaatact caataaaact taaagaaatt aaacaatttc
     6181 taaaaatacc ttgaaaatag aaccttattt gccatttata aattatataa aaagggatta
     6241 tataaagtca tatatgaaaa aactatatta tactatcttt tctttttgga ataaactata
     6301 ctttaaatat agatatttaa tttaaataaa ttttacagta ttaatagtaa attatcttag
     6361 aaaggaatgt gctttatatg tctacagaca aagttgttgg aatcatagat gaagaaacgg
     6421 cagaacttgc aggaattgaa tatactggta aaatttatgc ttcttctggt gttataaaac
     6481 atataaagaa aaaacataga tgtcaactga gtaaggatat ttttaatgat ataatagaca
     6541 ctataaaaat ggtattaaag tcacctgaat atataggaag tcatcctaaa aaacctggaa
     6601 aaagtgtgga gtttataaaa aaaattgatg attatatttt agtagctaca gaattagata
     6661 caaaaaaagg atatttatat gtatcttcaa tgtatgctat aaaagaagca aaattagaaa
     6721 gtagagtaaa cagtggaaga gtaaaacaat ataatggtta acataatatt attaattttc
     6781 cctaaaatat tgaaaaatat tattatataa gttataatat taatatacac gtagatattt
     6841 attagttaga tttgaggttg gaaaaggcac ccaatacgct actatagagt agttaataga
     6901 gatgcaggat acgccgccct gccaaatcta attaaattaa aaagagagga ttaattcctc
     6961 tcttattgtt tttttgagat actaatttaa tctataatag aaagattgaa ggtcgtttat
     7021 acaaaaaaat tttcagttat atacattaaa ctaattaaat aagatattta taatctatat
     7081 gtgatacata ttatatatta ataaaagaaa aatatataga aaatccttat aaaaatttaa
     7141 attgtaatga ataggaagta attaaaaaga atttttattg atttttaaaa atttagttag
     7201 aaactatatc attatggtaa aaaatgtatt ataatgttta gaaatattat aataaggagc
     7261 gattaaacat gaatctatcg aagaaaatag aagataaaag aaaagctaaa cagagagctg
     7321 aaaaagttaa gaaagctaaa attgctacag ctggtgtggt attaggagct gttactggtg
     7381 cagtgagtgg agtacttttg gctcctaaat ctggaaaaga aacaagagag gatataaaag
     7441 atgcttcaca acaaattgct gaaaagataa atatgaaaac tgtagatgta aaaggcaaag
     7501 tatctgagaa gctagaggat aaaaaaggaa actttataga atcaaagaaa aaaataaaaa
     7561 aatatataga taacaaaaag agtgttgaaa attctagtga ggaagataaa ataatagata
     7621 tagttgaacc agttagtgtt actgaggaat aatatggaca atacaataac gattaacata
     7681 agtataatat atgtattatt agctatactt gcttgtattg ctttagttta tttaattatt
     7741 gtacttgtta aactacataa gattttaaat aatgttggaa ctatgttaaa tgaaaatact
     7801 caaaatataa atacaacttt aaataatctt cctaatgttg tagaaacttt tggagaagta
     7861 ggagaaaata tgaaagatgt aacagaagta gttactgaag ttacagcaga ttttcttgtt
     7921 actaaagaca gtgtcaaatc aaatatggat gttatagttg atatattgac tataattaaa
     7981 aacatttttc tagataaaaa ataataagtt taattaaaat aagcctataa gatataattt
     8041 aaacgacctt aaaatagcat ttataaggtc gttttttatt agcttgattt gacactatgt
     8101 gtttttaata attggtaata ttcctcttta tcatttgaac atatatatct atgcttgttg
     8161 tttcaattac atccataaga acatctttac attcaagctc aaaatcttcc attccttcta
     8221 aatattcatc atcttcatca aaaaagatat aagaattata tagccattct tcaaattttt
     8281 cttcaagtat atcccaatac gaactccaaa ataatccaca acctgatata taagatgctc
     8341 tactttgatt tatataaacc tcctctagaa gcttttgtaa tctactgcta taaagaaaat
     8401 ctgctcttcc actgcttgat attaattcat ttaaatcttc tattgacatt aattcaactt
     8461 taccactttt atcataagga gtataatttt catcaaccca tttatgtggt ttgttttctc
     8521 tgcatactgt tgctatcaac tctacaactt ttgttcttat cattttttta tcctaactta
     8581 tttatttttt ataaaataat catgatttta taatttatct atttcttgta atgctaattt
     8641 aacagtttca tatctatcag caccatttat tactacatca ccttttacaa gtttattagc
     8701 ttctccacct acaacataaa cctttttacc taaaccttgc ttataactag acgcttcaat
     8761 tattaaagaa tctttcaatt gccaatgtaa aatctgagca gccactttat cagcatcacc
     8821 tgtataaacg attacatttt catacacttt attttcccct ccctcttgag aatttgatat
     8881 agatttgttt agtatacctt ctgctatcaa tttagcaact ttatctttat tattaacata
     8941 ataatctgta tctgctttac tatctacaaa acatacttct attaatattg ctggtgcaat
     9001 agtatgatta agccaataaa gacctctaac atcagacttt gcgcccctat ctttgaatac
     9061 tgtagctaac ctagtattca ctctttctgc ataggttttg ccattattag tcttatatat
     9121 tgtttctgtc cctactggag ttgaagttgt ggcatttgaa ttaaaatgaa tctgaacagc
     9181 caaatcagtt tcctgtttat ttgctatagc acattggtct gctaaatgat tacttgattc
     9241 atcaactctt cctgtataaa cagtagctcc acctatttta agccatttaa caattaagtc
     9301 attcagtatt cttgtttctt tgctttcgtt tatataccca acagctcctg taccttttcc
     9361 aattaaagtg tgccctggta ttattactac tttcaaacta acatctcctt tacaattaaa
     9421 tttaacttct atttaatata tgcataacct agaattttgt ttctttttat atcttatact
     9481 tttattataa cccattttgt aaaaatatag aatattaagt aaataatgtt aaaattataa
     9541 ttttgtatat aagacattac ttgattgcaa taattttata gcatattcat ctattctata
     9601 tccagttcta taatatatat gtttaattcc agcttgaatt atagccttag tacaatttaa
     9661 gcaaggaaag tgagttacat aaatagagca atttttaact gaaatacctt cttttgcaca
     9721 ataataaagg gcattttgtt cagcgtgaat ggttctaata caatgtccat ctctcatttc
     9781 atgaccaact tcactacaat gcttatctcc agaaatacta ccattatatc cagtagacac
     9841 tattctgttt tctgaattga caattatagc tcctacataa gctctatcac aagttcctct
     9901 ttcagctact gtttcgcaca gtctcataaa atattcttgc catgagcatc tattttcaag
     9961 ttttttattc aaattatata cctccaaaac ttatatctaa tatataagat ttatacctta
    10021 aaaataatat taaaaacaaa tttatacgat aaataaaatt tattaatact gtttttagtc
    10081 taaattattt cattttaaat taaagttaca aggaatctaa aattatatat atctttcttc
    10141 gtaatattaa tgttacaata taaaaaactg tctcaataaa atagagacag ttttacagtc
    10201 aaagtttata atacaagttc atatttttct ttaaattctt ttacagcttc gggccatgcc
    10261 ttttgttctg taataccttt ttctttagct attttaattg caatctctct tatcattgca
    10321 gcgccttcta atattcccat ttttaatctc ccttcaaata tctttttgta tagaatataa
    10381 atagtgctaa gatttattac atgctgcata tacaatatct atacaacaca taacttgtaa
    10441 attcctttta ttttcatacg tctttaaccg acatataatt atattcaata agttttaaaa
    10501 ttatgaactc aattataatt atttttattt ttttagaatc taaacactaa aaattgtagg
    10561 taaatttgtc ttatgccttt ataaatattt ctacagtttt aattactgga catatctatt
    10621 tttattataa aaagcgatta aaaatcgaga atatccgcat aaaaactgta tataagcaaa
    10681 acggttaaag gaaaaagaag aaatttactt gaatgttaaa atgcgttgct tgaagcaatg
    10741 ggcagttttg cctataatat cggtaacaac tgaaagaaag gtggttagcc ctaatgttaa
    10801 gcgaaaacat taaaacaatc aggaagtcaa aaggactttc acaacaagaa cttgctataa
    10861 aactgaatgt agtgcgacaa acaatatcta aatgggaaca aggactgtca gttcccgatt
    10921 ctgatatgtt gatttccata tcagaggtgc ttgaaacgcc cgtaagtact ttacttggag
    10981 aaactattgt tgagtcggaa gttgataact taaaagtgat ttctgaaaaa ttagagatta
    11041 taaacttgca acttgcacaa agaaaaaaca tgagaagaaa aatgtttcat tggttattta
    11101 ttttattatg tgcagtcata ttaatagttt ttgtggtctt agggggacta aatagtcctt
    11161 acttggattg gaattatacc gaccctgaaa ccgctgtttt tggagtagct tttcatgctt
    11221 ttgagtggct atttgtcaga ttagtaccga ttgtccttat aggagcaatt attggaatct
    11281 ttttgacacg taagaaaata tgaagtaact ctgcttttta taatacagca agcgttcctt
    11341 aaaagcgtca ttctacatgg caatcgagga cgactatgta aggaagaacc tttttgattt
    11401 ccaactaagc gaagttattg aggacgacag taagaccaaa accgcattaa gtaaagtaca
    11461 ggaagcaaga ctgctggact tatactctca tgcgtcagat gcaggaaatg cgaggtctgg
    11521 tagcatgatt tacaacgatt tgtacaacga ctgctagtag aaataatatg gagataagta
    11581 ttatctacaa agtcagaaaa gaaatgactt gataatttac tcatgttata attattgatg
    11641 tgaaattaat aaatcgaaat tccttttttg gatttaataa tactgagtaa ggaaaaagtg
    11701 aattactttt gcaaggaggt gttaatatca ggcaagtaaa gtcttttgtt tttccagtta
    11761 tatccttaat attcttagac caaattagca aagttcttat aggattattc ttaatggact
    11821 ttgaaattga tataattggg aaatttttaa gattcaatcc tgttcaaaat acaaatctct
    11881 cttatggggg aaactttatt ggtattctat ctaatttatg ggtattggta ttgtttaaca
    11941 ttttagttat attagttatt atatctggat atgcttttta taaatcaaaa aatgaacaaa
    12001 caagctattc agtaaaagta attatgtctt gtggacttgc tggtacaata tgtagcttga
    12061 tagataaatt attttgggga ggaagtttag attttttgca gataccaagc ttttttattt
    12121 tcgacttaaa agactgctac cttactgttg cagaaataat atttgttgtc ataggaattt
    12181 tgcataatag agaaatatca atgaaagaat acatatattt ttgctatcgt cagtttaaaa
    12241 aataaattta gaagataaat ttaagtttca aggtaaactt atttaatcac agcaaatagt
    12301 tggcttactt aagcttttgg gctaaactgt gagcactaat taagtctctg atatctaaca
    12361 aacggagcac aaaaataaaa attaaatata aagcacagtt aattttgatt aaaaagttga
    12421 ctgtcttttc ttttgtagaa atttaagcat aggtaataaa gaaatgactg catttaagca
    12481 ttatgtatat aattggaggc aataaaaagc cagcaaagcc cataaaatag agctgtgcta
    12541 gcaacatgat gaattataag aagataatca aaaacttacg ctttatttta atttaaaaaa
    12601 atgattactg taaagaaatc attttttatt ataatcactg atacatcaaa tattctaaat
    12661 aaaattttta tttatctgga attgtatatt ttttctataa tattaactac agcgtacatt
    12721 gcccaagcac agatagccaa tacaaatact cccatcatta ctaaatctaa tttaaatact
    12781 tgagaaccat atactatcaa gtagcctatt ccatatcttg aaactaaaaa ttctccaact
    12841 attacaccta cccatgccat accaatatta attttagtta aatttattaa atttcctgtg
    12901 tttgcaggta atatgagttt aaataatatt tgagatttag tagctccaaa actttttaac
    12961 atcttaattt tttcttcatc tatattcata aaataattat aagctgaaag tatagtaaca
    13021 acaacagaaa tcgttacagc tgttacgacg attccttcta ttccagcacc tacccaaact
    13081 ataattatag gagctaaagc agtcttagga agagcattta aaactaccaa aaatgggtct
    13141 aatatttttg ataatttttc tgaccaccaa agagcaattg ctaccaaaat acctaataca
    13201 gtacctataa caagaccaag aacagtttca tatacagata ttccaatatg tttaaataat
    13261 tgaccactaa atgcatattg aataaataaa ttgtaaatat cacttggttt gctaaataga
    13321 aatgtattta taacatttaa gtcagctaaa agttcccaga ttacaataaa accaattaaa
    13381 attaatagct ggtagaataa tacatttctt ttttctcttt ttacaccttt aacatagttt
    13441 atatatcctt cagatctttt attaagcctc atgtgtatct agctccttcc ataatatgtc
    13501 gaaatacttt tgaaaatcag gaactttacg tgttttgaga ggcgtttttg ttccatccat
    13561 gttaagttca atatcgtaaa tattttttat ggtagctggt cttttagata gtattgcaac
    13621 cttatctgat atgcttattg cttctgctat agctaaaaaa gtgcaactaa ttgcttaaag
    13681 aaacagaatt atcaacttca gcacccatat aaacaatatt aagatttcct aaactgctat
    13741 cccaaacgat actattaata atagtagata ataacaatct cttatcatct aaactggcat
    13801 tatcaacttc atcattaaat ctcttcaaat tactaacaat aatatcaata ttaatactgt
    13861 cactactaat attgatgtta ctagattcca aagtattaat cttatccttt aaaatactaa
    13921 tctcattatt taggctctca atctgggaaa ctatataatc agaagcagta ctaccagtat
    13981 tttttgcaag ctctataact aaatttttaa taagtctttc cttatctaaa atttgatttt
    14041 taagtaaatt agtctcagat ttaaaaatat taaaaacatt atcagtctta atgttattac
    14101 tattgaatgc acttataata gactcttctt tacaattctt aattttatct ataactaaac
    14161 tttcaactaa tggaccatta agatttttac agttgcaact atcagaccca agtgtttttt
    14221 tagtaccaca aatataataa tactttaaat ccttgtcagt ttttttgcct ttataggtaa
    14281 ttctcatatt agaaccacat ttaccacatt ttataagacc agataaaaga gcagtttttc
    14341 cagttgatat ccttggagtt ttatcacgat ttttatctaa ttgattttgt acttcaagcc
    14401 atatttcagg ttctatgact ccatggtgtt ttgcaattgc tgctattgag ttagatgtat
    14461 ttttagcata ggtaaggatt ccacattttc tatctggagt acctacaaca tccataccac
    14521 tatttttaag gtaatctaaa atttcatcat tagcttttac atatgctgga tttctaagta
    14581 ttctagataa agaactaggg tcaaatttgc caccacgagg accccttatt ccattattat
    14641 agacatattt atataactta gataaggacc taagttctaa atatttattg tatattagct
    14701 ttacaatctc catttgttca tcatttactt gaagcttata catacttctt tcttttagat
    14761 tttcatctaa gaatgtgatt ttttcactgt tgaatccatg aggtgtattg cctccaagcc
    14821 atctaccact acgggctaat tcatacatat tgtcttttat acgttctgct attgtttctc
    14881 tttctaattg agcaaataca cttgatataa acatcatagc tcttcccatt ggagttgaag
    14941 tatcaaattg ttctttgata gatataaatg atatgcttag ttcatttaat ttttctatta
    15001 aagtagagaa gtcagataca tttctcgata tcctatctaa tctataacaa actaggtaac
    15061 taaatttctt atctttggca tcctgcatca ttttcttaaa ttgtggtcta tctatattgc
    15121 taccactaaa tccctcatct tcatatatca aaaaatcttt tacaccaata gactttgcat
    15181 aatcaataca taattgtatt tgattttcta tagaatcacc ttttccagta aatcttgatt
    15241 ttcttgaata aattgcagct ttcaaaatta aaacccccta taagttagga tatatatttg
    15301 aaactattta tctacaacct tttaagtaaa cttattagaa tgaatttatt aattaggtaa
    15361 atttatataa ttctactttt tataatatat gactatttat tttatttctt tactattcaa
    15421 gttctaaatc aataataaat tttgatattt aattgtatca ggacaaatct ctaatttcat
    15481 agattattaa tataaaatca taggttagtg tgaaaaagtt gaaatttaaa tattttaaaa
    15541 gataattttt ttgaactaat aggtataaca aaaatttata gggggattgc atatggaaat
    15601 caatgttata gaaattttcc ctaaagataa agctaaactt aataaaatag aaatggataa
    15661 agctagttgg tttgtaaata taataagtaa aaaatatcct aaagaagctt taaatgaagc
    15721 atttagtact ttagaaaaag aattaaatat aagtaaagct aatacataag ctttgattat
    15781 tgattttata tactattggt tttatacgct atgacttgac attatattaa tcaaatagta
    15841 tatttttaaa tatagcacaa tgaagtgtta aaagagcaat ggagctccat agataaagtc
    15901 tatggagctt ttttgcgtat ttaacttaag gaggatagga ctttgaataa ctttgagatt
    15961 aaaactagaa taaaatttgg agaaggctca ctaaaagctt tgcaagaatt aaaaaacaaa
    16021 aatgtactaa taataacaga cccttttatg gtgaaatcaa aaacaataga taaaataaca
    16081 tctaatttaa taaactcaac atatcaagtt tttgaagaaa tagtaccaga cccaccaata
    16141 gaagtagtag tagcaggaat agaagcattt aaatctataa atccagacgt aataatagca
    16201 ttaggtggtg gttctgcaat agatgcagca aaatctataa tggacttttc taaaaaaata
    16261 ttaaaaatta acgaagtaga gtttatagca ataccaacaa caagtggaac aggttcagaa
    16321 gtaacatcat ttgctgtaat aacagatagt caaaaaaaat gtaagtatcc attagtgagt
    16381 gatgatttac ttccagatat ggcaatacta gacccagaac ttgtaaaaac tgtaccaaat
    16441 tttataacag cagatacagg gatggatgta ttgacacatg ctatagaagc ttacgtatct
    16501 acaaattcta atgacttttc agatgcacta gctgaaaaag ctataaagtt agtatttaaa
    16561 tacttaataa aagcatataa agatggaaat gacatagaag ctagagaaaa aatgcacaat
    16621 gcatcttgtt tagcaggtat ggcatttaac caagcatcac ttggcataaa tcattctatt
    16681 gcacatgtat taggtggaaa attccatata ccacatggaa gaacaaactc tatattactt
    16741 cctcatgtaa tagaatataa ttcatcaata gtaggatata ctaacacaac ttactctgct
    16801 acagctaaaa aatatgcaca aatagcagaa ttagtaggac ttgggagtgc taatataaga
    16861 atatctgtta gaaatttagt aaatgaaata aagaaactac aaaaagaaat gaatatgcca
    16921 actaaattga cacaatgcaa attaagttta gaagatataa ctaatgaaga aagagaaata
    16981 gcaaaacttg ctataaaaga tacttgtaca ttaactaatc ctaaggtacc aactgaagat
    17041 gatataataa acatattaaa gaacattaaa taactacatt ttattacatg taaatataat
    17101 attatacaaa tagggaaaat gtttttaaaa atataaatta tatattgaca aatataaaac
    17161 ataaaactat aatgaaagta tcacaaaggc gtgatacttt agtagaaagc aatggagctt
    17221 cttaggaata ttaatattat tcttatggag ctccttttat tttaatcaaa tagcttttta
    17281 ataaactata ttcaaagaaa gcagggaata aatttgactg aagaatctaa gcaaagagtt
    17341 attcaagaat atgttcctgg aaaacaggtt acattagcac atatcatagc taaccctaat
    17401 gaagatatat ataagaagtt aggattagta cttgataaaa aagatgcaat aggaatactt
    17461 acaataacac caagtgaagc gtcaataata gcagcagatg ttgctacaaa ggcttcaaat
    17521 gtatctttag gttttataga tagatttagt ggttcagtag taatatcagg tgatgtaagt
    17581 tctgtagaat cagcgttaaa tgatgtttta gaagtcttag gaaatatgtt aaacttctca
    17641 tctacaaaaa tcacaaggac ataataatac aatgaagaat ataatattta tgggaaagac
    17701 aggtagtggt aaaactacct tatgtcaaaa actagaccag ttagaattaa agtataaaaa
    17761 aactcaatca gtggaacttt ataataatgc aatagacact cctggtgagt atatggaaaa
    17821 tagaaaccta tataatgcct taataacaac atcagcagat gctaaaatta tagcaatagt
    17881 gtatgatgcc acacaagaag aaaattatat agcaccaggt tttgccagta tgttttgcaa
    17941 agacgtaata ggaattataa ctaaaataaa taaagctact gaaaacgaag tcaatatagc
    18001 ttatgaaaga ctatcactag caggagcaag tcaaatcttt aaaatagaca cagttgataa
    18061 tattggactt gaaaaattat ttaaatatct agaaaaatat aaaaatatag atgaagttta
    18121 aggggaaata tttttttatt caaaaatatt attaaagtat gataaaataa aaaaatgtat
    18181 aaactatttt aagaagattt aatctttaag cgaggtagga acatggggaa aaaaatacta
    18241 ttggttgatg atgaaccact gttaaggatg gatacaaaag atatattaga aagtcatggc
    18301 tatgaaataa taggcgaagc aagtgatgga tttgaagctg ttgaaatgtg taaaaaacac
    18361 aaacctgatt tagttataat ggatatagag atgccaatac ttgatggtat aaaggcaggc
    18421 aaaataatat gtaaagaaaa tatagctggt ggagtacttt tattaacttc atttgaagat
    18481 aaagaatacg tagaaaaggc taaaagtata ggtgcttatg gatatttagt aaaaacagca
    18541 agtgaaaaat cacttatccc aaccatagaa atgtgtttaa ataaggtaaa tgaatttgaa
    18601 aaaatgaaaa aagatttaga aaaagtaaat tctaaattga atgaaagaaa attagtagaa
    18661 agagcaaaag gtatacttat aagagagttt aagatttctg aggatgaagc atacactaga
    18721 ataagaaaat taagtatgga taaaagaact acaatgatgg aaattgccaa aatgattata
    18781 ataggatacg atgactaata cgataaaaaa aatatcaact gcacaaacat acttaaataa
    18841 taacgaaatt gaaaaaatta tagaagtatc aaaatcctta gatttaatgg cttcttttta
    18901 tgaagctgat gtttttatag atgtactaag taaatttgat gatgaagcaa ttgttgtggc
    18961 acatggtaga cctaaagaaa agtcaatgta ctgtgaaaat gttataggta aaaaggcttt
    19021 aattgaaaat gaaccaggag ttataaagtg cttaaaaaca ggagaaagag taagagatat
    19081 taaagcttta acacaggaat ataaactggt caaacaaaat attcagccaa taacactaga
    19141 tgacaaagtt ttagcagtac taatagttga aaaagatata agtagtgaag ttaagaatga
    19201 gtttaatgct agtgaagacg aagaaaataa aaatttacat cagtttataa aacttattgg
    19261 aaataatgac tttttagttg ataatttaaa ttcagccata ttaatatttg ataaaaatgg
    19321 aaaattaaaa attaaaaatc gtattgcaac tgagatatac aaaaatcttg ggtttggata
    19381 tgatatacaa gatatgcatt acaatgattt agatatagaa accaacacct ttgaaaatat
    19441 attaatggat gaaaattatg atgagacaaa tgaagtttca ataggtaata tgttttttaa
    19501 aataaagacc atatacatca aagatgatga atttaaggtt tgcaaaatag tacaagatat
    19561 aagtgattta aagagaaaag aagaagaatt agttttgaaa acagtggcta taagagaagc
    19621 tcatcataga gtaaaaaata atcttcatac agtaatatct ataataaaaa aacaaagtag
    19681 attatctcaa aatgatgaag taaagcagtg tttagataac ataataaata gggtatttgc
    19741 aatactttcg actcattatt tactatctaa agaagttgat aataatatat ctatacgaga
    19801 aggtatcaat ttattagtgt caaatattca aggtggctat ttatttagta aggatataga
    19861 tatacgtata actggtgaag attttaaaat tagtggagaa aaagcaacag caatactttt
    19921 ggttataaat gaaatactac aaaattgtta tgaccatgca ttttcggata gagaacatgg
    19981 tactatacaa atattaataa ataaagataa cgactataga aatattgcta ttatagatga
    20041 tggaattgga tttgatagta ataatataaa taaaaatagc ttagggacat atataataga
    20101 tagttatata acacagatgt taaaaggaaa tatagagaga aaaagtagtg agaatggtac
    20161 agaagtatta attactatac ctacacaaat taatatttaa ataataactc atctacaaag
    20221 tagtagtttt aattgagcaa agaggcttaa ggttattaat agattaagtt aattgaatgt
    20281 atttataaaa attataagta tatattcaat ttaacaggta tttattataa ctttaagcct
    20341 ctttgcttgt ttaagacata cttaaatttt aggaggtgag aaaatgagag aagagttatt
    20401 aagtgttggt attgacattg gaacaagtac tactcagtta attttttcta aattaatagt
    20461 agaaaatact gaatcaaatt tttcggtacc tagaataagt atagtagaca aagaaattat
    20521 ttataaaagc aaagtttatt tcacccctct tatttcaaat aatgaaataa atggtcaaca
    20581 aataaaagat atagttgaaa atgaatataa aaaagcaaat atatctaaag aagatataca
    20641 tacaggagca gtaataataa ctggtgaaac agctagaaaa gaaaatgcaa atgatgtact
    20701 tcatactttg agtggatttg ctggggactt cgttgttgca acagcaggac ctgatttaga
    20761 aagtataata tcaggaaaag gagctggagc tcatatttat tcaaaagaac attcaactac
    20821 aattgtaaat atagacatag gtgggggaac tagtaacata gcctcattta aaaggggaga
    20881 agtaaccgat actgggtgtt tggatatagg tggaaggctt gtaaagatag ataaaataag
    20941 taaaaaaata acttatatat cacctaaaat agataaaatc ataaaagata ataatttaaa
    21001 tcttcaagta ggcacaatgg ctactgtaga aaatacaaag ccaatagtgg atataatggt
    21061 tgacttatta atggaaagca taggattaaa gaaacagaca cctttgtttg attttataat
    21121 aaccaataaa tcaataagta tagatgaaaa tattaaaaat gtttcattct ctggtggagt
    21181 agctgattat atttactatg atggagaaat aaaagattat tttgaatatg gtgacttggg
    21241 aattttactt gggcaagcaa taaaaaattg tgaatacctt aaaaaagtaa atgtagttaa
    21301 atctatggaa acaataagag ccacagtggt tggagcaggt tctcatacta ctgaagtaag
    21361 tggaagtaca ataacttaca ctagcgaaaa gtttccactt aagaacttgc cagttttaaa
    21421 attatcaatt gatgaagaaa caggcacttc aaaacaaatc agtgaagcta taaaaaataa
    21481 acttaattgg tttaaactag aaaatgattt acagaaagtt gctatagcca tgataggaaa
    21541 gaaaaatcca acctttttag atatacaaga gtatgctaaa gggtttgtag atggaatgca
    21601 acaaatcata gaaaatgatt taccttttat agtaattgtt gaaaatgata tggcaaaagt
    21661 gttaggtcaa gcaatatatg cattattaaa ttatgaaaaa gaaattgttt gtatagacag
    21721 tgtcaaggtt gaaaatggag actatatcga cattggaaaa cctatagttg aaggtaaagt
    21781 tttacctgtg gtaataaaaa cattagtttt taattaatag aaggaggtaa gtaaatgatt
    21841 ttaaatacaa aattatttgg acgtacttat cagtttaaag gcttatatga tgtaatggct
    21901 aaagctaatg aagaaaaatc aggagataaa ttagcaggtc ttgcagcaga atcagctgaa
    21961 gaaagaatag cagcaaaagt tgttttatca cacataaaat tggaggatat aagaaataat
    22021 cctgcagtgg catatgaaga agatgaagta acaagaataa tacaagatgc tgtaaatgaa
    22081 aaagtttatg aagaaataaa aaattggaca gtctctgaac ttagagaatg gctattggat
    22141 tcaaatacta caagtcttga tataagaaga atatcaagag gattaacttc tgaaatgata
    22201 gcagcagttg caaaattaat gtcaaatatg gacttagttt atgcagctaa aaagataaag
    22261 gttactgctc actgtaatac aactatagga gaacaaggaa cattatcagc aagacttcaa
    22321 cctaatcatc caacagacga cccagatgga atacttgcat cacttcttga aggtttaact
    22381 tttggtatag gagatgcagt acttggatta aatccagttg atgactctgt tgagagtgtt
    22441 actaaagtat taaaaagatt tgaagaagta aaacaaaaat atcaaatacc aactcaaaca
    22501 tgtgtattgg cacacgttac tacacaaatg gaagcaataa gaaatggtgc tcctgcagat
    22561 ttaatattcc aatctatagc aggttctgaa aaaggaaatg aagcatttgg atttaatggc
    22621 gacactatag aagaagctag acagttagcc ttaaaacacg gtacagctac aggacctaac
    22681 gttatgtatt ttgaaactgg acaaggttca gaattatctt cagaagcaca tcatggaata
    22741 gaccaagtta ctatggaagc tagatgctat ggatttgcta aaaagtatga accattctta
    22801 gtaaatacag ttgttgggtt tataggacct gagtacttat atgatgctag agaagttgta
    22861 agagcaggac ttgaagacca ctttatgggt aaactacatg gcttaccaat gggtgttgat
    22921 gtttgttaca ctaaccatat gaaggctgac caaaatgata tggaaaactt agccatacta
    22981 ttaacaacag caggatgtac gtattttatg ggaatacctc atggagatga tgttatgctt
    23041 aactatcaaa caacaggata ccatgaaaca gcatcactta gagaaatgtt tggactaaca
    23101 gcaataaaag aatttgatgc ttggatggaa aagatgggat tctctaaaga tggtaagtta
    23161 acagagttgg cgggagacgc atctgtatta ttaggatagg aggtatttaa tatgaatgag
    23221 aaggatttaa aagcattggt agaacaatta gttggacaaa tggttggaga attagatact
    23281 aatgttgtgt ctgagactgt taaaaaggca actgaagttg tagtagacaa caatgcttgt
    23341 atagatgata taacagaagt tgatataaga aagcaattac tagtaaaaaa tcctaaggat
    23401 gcagaagctt atttagatat gaaagcaaaa acacctgcaa gattaggtat aggaagagct
    23461 ggtactagat ataaaacaga aacagtttta agatttagag cagaccatgc tgctgcacaa
    23521 gatgctgtat tctcttatgt agatgaagaa tttataaaag aaaataatat gtttgcagtg
    23581 gaaactttat gtaaagataa agatgaatac ttaacaagac cagatttggg aagaaaattt
    23641 tctccagaaa ctataaataa tataaaatct aaatttggta caaatcaaaa ggttttaata
    23701 ttagttggag atgggcttag ctcagctgca atagaggcaa atttaaaaga ctgtgtgcca
    23761 gctataaaac aggggctaaa aatgtatggt atagattcaa gtgaaatttt atttgttaaa
    23821 cattgtagag ttggtgctat ggaccactta ggtgaagaat taggttgtga agttatatgt
    23881 atgttggttg gagaaagacc aggattagtt actgctgaat caatgtcagc atatatagct
    23941 tataagccat atataggaat ggcagaagca aaaagaacag ttatatcaaa tattcacaaa
    24001 ggtggaacaa ctgcagttga agcaggtgct catatagctg aacttataaa aactatgtta
    24061 gataaaaaag cttcaggaat agaccttaaa taaagtcgag ggagtgtaga atatgaaaaa
    24121 tgatgtaatt cgtcctaata tactaggaat taaaataatt tcaaatataa gtccagaaat
    24181 ggcacaaaaa ctagaattaa aatcacatca caaaagctta ggtttaataa ctgcagactg
    24241 tgatgatgtt acgtatacag ctcttgacga agcaactaaa gcttcagaag ttgatgttgt
    24301 atatgcaaaa tcaatgtatg caggtgctgc aaatgcttca acaaaacttg ctggtgaagt
    24361 attaggaata atagcaggtc caagcccagc agaagtaaga agtggtctaa atgcagtagt
    24421 tgattttcta gagtatggag caacttttat aagtgcaaat gatgatgatt caatagcata
    24481 ctatgctcac tgcgtatcaa gaacaggtac atacctttca gaggtagcag gaataagaga
    24541 aggtgaagca ttagcttatt tagtagcacc accacttgaa gcaatgtatg cactagatgc
    24601 agcaatgaaa gctgcagatg ttaagatgtg tgaattattt gcacctccaa ctgaaacaaa
    24661 ctttggtgga gcattactta caggttctca atcggcttgt aaagcagcat gtgatgcatt
    24721 tgcagaagca gtaaaatcag ttgcagacaa tccaacagga ttttaaggat agttagatgg
    24781 atgctatagg cttaatagaa gtaataggat atgttgctgc aatagaagct tctgatgctt
    24841 gtttaaaatc tgcaaatgtt aatattgtaa gagttgataa ggttggagca ggtattgtta
    24901 ctttaacaat atgtggagat gtcggtgctg taaaagctgc tttagaagca ggtgaaatag
    24961 cagcttccag agttggtaca ttaagaacat cacatattat accgagaatc cataatgaag
    25021 taacaaatgc tttattcaaa actaaagaac ctaaagtctg tgaagtttca gaagataaag
    25081 aaaaaaactt tgagattaca ttggaaatag ctgataatgt atcgaaaaat ttatcagaaa
    25141 aagaaaatgt aattttagat gtcaatgaaa acagtggaga tactgaaaat ttatatagtg
    25201 atatagataa aacaaacaaa aaaattgaaa cagttgatga tagtttaaca gaagctaatg
    25261 aggaaaaaat agaaaacact aatgataaag aagtattgga acaagttaaa atagaaaatt
    25321 ccgattttga tagagatgac ctatcaaaga acagtgtaaa aaaacttaaa gctatggcta
    25381 agaaattaga ttcttcaata acttataaag acttaaatgt tcttaaaaaa gaagaattaa
    25441 taaacttagt taaaaagctt agtagaaggg atagatagtt atgacacttt tagataaaga
    25501 tttagtatct atacaagaag taagaactct tgtaagaaga tctaaagtgg ctcaagagaa
    25561 actttctaaa atgagtcaag agcaaataga taaaatagta aaagctgttg tagatgcagc
    25621 atttaataat gctactaaat tagctaaaat ggcaaatgaa gaaactggat ttggaaaatg
    25681 ggaagataaa gtaattaaaa atacttttgc atctatggga gtttatgaaa ctttaaagaa
    25741 cacaaaaact attggaataa ttggtgaaga taaagaagcc aatacgatag atatagctac
    25801 accagttgga gttgttgcag gtcttatacc ttcaacaaac ccaacatcaa cagtaatata
    25861 caaaactata atatctctaa aagcaggaaa tactatagtt ttctctccac atccaaatgc
    25921 aaaaaactgc atacttgaaa cagttaatat aataagtgat gctgctataa aggctggagc
    25981 tccagaggat tcaatattat gtataactaa tccaagtata gttggaacca atgaattgat
    26041 gaaacataaa gatacaaact taatactagc aactggagga gaagcaatgg ttagagctgc
    26101 ttactcttca ggaacaccag ctattggagt tggaccagga aatggaccag catttataga
    26161 taaatcagca aatgttaaat tagcaatcaa aagaataata gattctaaaa cttttgataa
    26221 tggtgttata tgtgcatcag aacaatctat agtaatagaa aaatctatgg aagaaactgt
    26281 tttaaaagag cttaaaaatc aaggtgcata tgttttaaat gaggaggaaa gtgaaagatt
    26341 agcaaaattc atattaagag ctaatggtac tatgaatcca caaatagttg gtaaaagtgt
    26401 tgaggtaata gcaaatttag cagacttaac aaatgtacct aaaaatacaa aagttctagt
    26461 tgcaagagaa aataaagttg gtcacaatgt agcctattca agagaaaaac ttacaccaat
    26521 actagcgttc tatgttgaag aaaatgtaga agctattatg aacagatgca gagaaatatt
    26581 gttaaatgaa ggtgcaggtc atacattctc aatgcatgta aatgatgaag aattggtaaa
    26641 aagatttgcc cttaatatgc cagtatcaag aatacttgtg aatactcctt cagcacttgg
    26701 aggaataggt gcatcaacaa accttgtacc agcactaaca cttggttgtg gtgcaatagg
    26761 tggaagttca acttcaaaca atataggacc acttgattta ataaatgtta aaagagtagc
    26821 ttatggaatc aaagaaatag aagaacttgg aagagataaa tctcaagttg aaaaatcaat
    26881 gtttgactca atggataaag aagaattaat aaatcttctt gttcaaaaac tagtcaaaga
    26941 actagcataa ctaaaataaa caatgaaact tatggctatc gctataaatt tctaaaaata
    27001 taaactataa aaaactataa aattaaattt ttggaggata agattatggc aagtgcaaac
    27061 gcattaggaa tgatagaaac taaaggatta gtaggagcaa tagaagcagc agatgcaatg
    27121 gttaaagctg caaatgtaca attagtagga aaagagcaag taggtggagg attagttact
    27181 gtaatggtaa gaggagatgt tggagctgtt aaagctgcta cagatgcagg agctgccgct
    27241 gccgagagag ttggagaact aatatcagtt catgttatac caagaccaca ctttgaagta
    27301 gatgctatat taccaaaggt atcagctgag taatataaga ataattataa aatttaaatt
    27361 ttgattgaaa aagaggctat ctcaaaaatg agtcttacta ataaactcaa tgtattttga
    27421 ggtagtcttt tttatacatc taataggaga tgtgataaaa tgggtgtttt aacagaaaac
    27481 gaagtaaaaa gaaaaattgg aaaaaacaaa aataatataa ctgaatttta tatagaaaaa
    27541 ggtcaaataa taactccttc tgcaaaatct tatttagctg agagaagtat tgagcttaaa
    27601 tatgttgata aactttcaga tgtaaacaat gaacctaaag aagttgtaaa agaagtagtt
    27661 aaagagaaaa aatatagata tactactgta tttggcgcta aattggatga aaaaccagaa
    27721 catatgactc aattaaatgg aaatctttta gtttttaaag accataaaag aataatattg
    27781 agaggaaaaa tagattctct tgaatcagaa atactaaagg tacagatact ttgtcagaaa
    27841 ctagatatgc caaagcttgt taaggaattg caagaagtat tagactttgt aagaaatata
    27901 atgagatgtg aagttttaga tgaaaagcta ggggacttta aacttttagg attaactcct
    27961 caagaactta gagaacaatc tcactatcct aaaaaatact ttggtatagg acatgagttc
    28021 ccaagttatg aaatgggaga agtagtagta gctataaata gtataagaag taatacacga
    28081 gaggttgaac ttgcagccta tgaagcattt aagggtgagt atggaaatgt tcacagagaa
    28141 gatttaataa aggcacttaa tagattatcg tcagtatttt ggataatgat atataaggtt
    28201 agaactaata agtataagta gttggaggac ataatggaga atctattaaa tgaaatagtg
    28261 gaagaagtaa taactagagt taaaaaagaa gcatttatag aagttgaagc atcaggaaga
    28321 cacgttcact taagtagaga agatgtcgat aaattatttg gagaaggata tactcttaca
    28381 aaactaaaag acctatctca accaggtcaa tatgcatgta aggaaagagt tacaataact
    28441 ggtcctaaag gaagtataaa aaatgtagtt gtacttggac catgtagaaa tgaaactcag
    28501 gtagaaatat ctttaacaga tggttcaact cttggactaa aagctcctat aaaacaaagt
    28561 ggagacttag aaggtacttt aagtattaaa atatcaacac aatatggtga agttgaactt
    28621 gataaggggt taatggttgc taaaagacat atacacatga ctcctaaaga tgctgaaaaa
    28681 ttcaatgtat gtgataaaga gatagttgaa gctaaggtga tgggtcaaag acctttaaca
    28741 tttgatgatg tagtaataag agtgagtgac agttttaaaa cttatatgca tatagactat
    28801 gatgaagcca atgcatgtgg ttattcaaaa ggaactgttg ctaaaataat aaagaaagcg
    28861 taaatttaac ctactatata aattacctct agggaggatt taatatgaat tatgataacc
    28921 ttgtagattt aataacggaa gaaatctata aaaaaataaa tagtaatgaa ataaaaatat
    28981 ctaataaacc taaagctgtg attgtatttg aacaagataa caataaattt aacttattaa
    29041 aagatgaatt tgaaatagta gaatttgata aaagtataag ggaatgtgaa atagtgatag
    29101 tttcaagact ttgtatgagg gggctatcga atatagcact tggaaattca acaagtgatg
    29161 aagaaagatt tatactaaaa atgattatga agggcaaaga agtatatgtc ctagatgaag
    29221 gaattgaata caaaaaatat aaggatactg caccaaaagc attatataag aaatttatgt
    29281 catttgaaga tgaaatatgt aaatttggtg tagaaattat aaaagactta aatgttataa
    29341 ctaaaaataa gttaaatata aagaaagaac tagaaagtac tagaggttct aaaaaagaag
    29401 atacaaaagt tttagataaa gatgttttaa atttaaccag tgtagaaagt gtaaaaatag
    29461 ataatgaatt tagtttagat ttaaggaata aaaaacttat atcggaagct gacttaagaa
    29521 aaccaactat aaatggagtt aaaaacatat tagttaataa aaaaagtata ataacaccat
    29581 tagctgtaga ttttatgaga atacaccatc tcaaactaaa gaaagtgtaa ggaggtaatt
    29641 ttatggatat aggaaaagtt gtaggtaatg tttgggctac aagaaaagat gaaaaattat
    29701 gtggccaaaa acttttagtt gtaaaaattt taaaaactaa agacacatac aaggaaggct
    29761 tcatggttgc agccgataat gcaggagcag gaaatggaga cttagttctt atatccaaag
    29821 gttcctcagc tagagagtcg attgaaaaat ctcatgttcc ggtagatgca actatagttg
    29881 gagtagtcga ttcgtttgag gtgtttgatg aataaaagta taggagctat agagtttaaa
    29941 agcattgcta aaggtataga agtatccaat gaaatgataa agaaatcttc agttgatgta
    30001 ttgtacttaa aaagtatttg cccaggtaaa tttctaataa tagtaggtgg agaaacttct
    30061 tatataaatg aatgtgtaga ttatggaata aaacttggag aaggatatat tgtagataac
    30121 ttcgtaataa atgcaatttc acaagaaata ttagatggat ttaaaaataa gtatcaaaag
    30181 ctagatagta tagtctctat aggcgttgtt gaaagtagta aagtatgcgc tggaataaaa
    30241 atgcttgata agactttaaa atctggcgac ttagtattag taaaacttca attatctttt
    30301 gctataggtg gcaaattagt atatatagta gcaggagatt taagtagttt agaatatgca
    30361 ttaaaagaaa gtgaaaatgt agtaagagaa aaagaagtaa tatataagac tgtaatacca
    30421 tcagtagaca gtcaaataat aaaaagtcta ataaaataat ggggggaatt atgagtataa
    30481 acgaaattat aatctatgta atggtagtct tcatggtact tggagctata gataaatgta
    30541 taggtaacaa atttggtctt ggagaacaat ttgaagaagg tataatggca atggggtcac
    30601 ttgcagttgc aatggttggt gttatatgtt tagcaccagt tcttgctgat gtattaagac
    30661 caattgtagt accagtattt aatatacttg gagctgaccc agctatgttt gctggaagtt
    30721 tattagctaa tgatatgggt ggtgcaccac ttgcacttga acttgcgaaa gaccctaatg
    30781 ctgggttatt tggtggatta atagtagggg ctatgatggg acctacaata gtatttataa
    30841 taccagttgc gcttggaata attgaaaaag aagaccaaaa attcttagca acaggaatac
    30901 ttgcaggtat aataacaata cctattggag cattcgttgg tggattagtt gcaggattcg
    30961 aggtaatgat ggttcttaga aacttagtgc caataataat atttgcagta gttatagcac
    31021 ttggattatt aaaattcgaa aatgctatga taaaaggatt cacatacttt ggaaaaggtg
    31081 tagtaatagt tataacttta ggacttgctg ctgccatagt tgaagcttta acaggaatag
    31141 ttgtaatacc tggaatgaaa ccaatcagtg aaggtataga aatagttgga gatatagcaa
    31201 tagttttagc aggagcattc ccattagtgt ttgttataac aaaggtattt aataaaccat
    31261 taatggcttt aggaaaagtt cttggaatga atgatgtatc agcagcaggc cttgttgcaa
    31321 gtttagctaa ctgtatacca atgtttggta tgatgaaaga tatggacaat agaggaaaaa
    31381 taataaatgt agcattctct gtatcagcag cattcgtatt tggagaccac ttaggattta
    31441 cggcaggatt taattctaat atgataacac caatgatagt tgctaaatta gttggtggta
    31501 taacagcagt attgttagct atggttatcg caaataagac actaaagaag gagaatgtat
    31561 aagatggata tatcaaatat agataaaaat ttaattgaaa cattagtaag acaaataata
    31621 gaagaaaaaa taagtggaac taaagacaca gtagattttg ttagaaataa agacattagt
    31681 ggaataactt ctataaagtt accaactgta aaagttagtg aatctgatag attagataca
    31741 gggaatccaa gtgatgtagt ttacacaaaa gatttattta cattagagga aagcccaaga
    31801 ttaggttgtg gtatgatgga aatgaaagaa acaacttttg attggactct aaactatgat
    31861 gaaatagatt atgtaataga tggaacttta gatataataa tagatggaag aaaggtttct
    31921 gcttcttcag gtgaattaat atttatacca aaaggaagta agatacaatt ttctgtacct
    31981 gattatgcta gatttatata tgtaacatat ccggcagatt gggcatctca aaattaataa
    32041 aaatcaagtt aagttaataa taatcaaata aataatttaa aatacaaact cttaaataag
    32101 cacacatatt taaaaaagct atgaattaaa attcatagct ttttttataa agaatgttat
    32161 attttagacg tattttttct atatttactg ggagacatat tatatttttt attaaataat
    32221 ctaataaaat gctctacatt tggataacca atactatttt actgataatc ttttccttat
    32281 cactaatctt acattttaaa atattatttt tactcgtaat attatcataa gaatttgttt
    32341 cttatttaaa actaattaga attataaagt ttattgccat gttattaata aaataaatcc
    32401 agttaaatcg agtgctagtt aaagtaataa gaaactttta caatggtttc ctttatcgat
    32461 tgaaataaaa gttaatatgg tataatatct aaagagagaa tcttatcaat tagaatatgc
    32521 atagaaacaa gtggcttaaa aggagacgtt atatggaaga gatagtaaag aaggaacaag
    32581 caagtatgaa tgatattttt ttgtatctta aagctaaatc aaactcatta tataaatttg
    32641 taatattata taatgagttt atcaataaac ctaaagatta tggaactggg gaacttataa
    32701 acatggttga agtacatatg ctaacagcga ttgaagaaaa tccaggaata agtccaactc
    32761 agttagctaa aatatggaac agaactaaag gtgcaatatc tcaaactata tctaaattgg
    32821 agaaaaaggg ttatataact aaagaaaaga aagaaggaaa tgcaaaaact atattactat
    32881 atccaaccac atcaggagta gagttaagta aggcacataa actatatgac accatagatg
    32941 ttacaagaac atttgaatac ttaatcaagg agtgtacatt agaggagata gatagttttt
    33001 ataaagtaat tgatttgttt attaatttat tagaagaatc tccgcaggaa aataatgatt
    33061 ctgaaaaagt gtagctgaga ttgaagttga ataaagagaa atagatatta tagaagtagt
    33121 acttaagtac acattatata aaaatataat aggtatagga ttaaaaagtt tagtggttta
    33181 aagtttaacc actaaacttt tttaatgtct ataatctact attatttaat ttactaaaaa
    33241 taaaaaaact cattatatta agataaaaat agaaaaataa ctagaaaaat actataatat
    33301 atcagcttaa tacagaaaaa agttaaaaaa tttgagaaaa ataaaaatga aaacgtttta
    33361 tattgacata gagaaaaagt agtgatacca tttaaatata gtttagtagc taaactatat
    33421 ttaaattata ataactattt tagggggatg ttatgaattt aaaacaatta agtgaaaaat
    33481 acgaagaata tgtaattcaa atgagaagag aatttcataa gtatccagaa ttatctttta
    33541 aagaaataag aacaacccaa agaataaggg aagaattaca aaaaataggg gtcccttttg
    33601 tatctattga accaaatatc gtaatagcta ctatacaagg caaaaatgaa ggtaagacaa
    33661 ttgcaattag aggagatata gatgcgcttc caatgcaaga agattcagat gttgaataca
    33721 aatcagaata tgatggaata atgcattctt gtggacatga tgctcatgga gctatgttac
    33781 taggacttgc acatatgcta aatgatataa gaaaagattt aaaaggtaga gtattattag
    33841 tttttcaagc agctgaagaa gttggtggtg gacacaagga gataatacag tactttaagg
    33901 aaaatggagg accagataga ttaatagcta ctcatgtttg gtccgatatt gaagctggta
    33961 aaatttctgt tgaaccagga cctcgtatgg ctggtgggtc tggttggaga atagacataa
    34021 caggtagagg aggtcatggt tctagaccag atcaaagcat agatcctata aagccagctt
    34081 gtgatatagt tttaaaagta tcttctatac cagttaatca tataagtgta ctagaacaat
    34141 gtgttgtaca tgcatgtgca atacatggag gaactacaat aggaaatgtt attccaaaca
    34201 atgcagaggt aataggtgga tatagatatt ttactgaaga atcaggcaaa aaagtgtttg
    34261 acattataaa gcaaatgagt aatggtgttg gacaagttta tggagtggat gtgaaggtta
    34321 ctcatactgg aggcatagga cctgttatca atgatgaaga agcagttaag atggctaaag
    34381 aaatagtttc taatatagat ggattggagt tagattctta tgagccaata tgtgcatcag
    34441 attgttatgg tgaaatatta aaagagtatt ctggctttta ttgttatcta ggggtaggta
    34501 acaaagaaaa aggaataata tatgcacaac accatcctaa gtacaatata gatgaagata
    34561 cattaaagtt aggttgcgaa tttatggcta aatatgcagt tgaattttta aataaaaata
    34621 ataactaaaa taaatcgaat tttataaatg ggggggatga aaatgcaagg tgcattaaag
    34681 gaaaataaga aaaaaagtgg tggaggattt ttaggatgga ttgaaaaagt tgggaataaa
    34741 atgccacatc ctctagcatt atttacatat attacattga tagtagtagc attatctgca
    34801 atagcaagct ttttaggttt ttcagcaaca agtcctgcta caggaaagtt aataaaagtt
    34861 atgaacttaa taagtgcaaa aggtttagta ctatttatgc aagagtttgt taagaacttc
    34921 caaaacttcc ctgtgcttgg agtagtttta gttatggcag ttgccacagg agtttgtgaa
    34981 aagacaggat ttttttcaac tgccataaaa atgagtttat caaaagttaa ggggaatgcg
    35041 gttgtattta taatagcttt tataggagta tttgctaatc aagctggtga tgctgctttt
    35101 gtattagtac caactcttgc aggagcaata ttttatggat taaatagaaa tccattagct
    35161 ggtatattct gtggatttgc atcagttggt ggtggatttg caacagctgt aattcctggg
    35221 ggatgggacg ttacgctaac gccaataact gtatcagctg ctcaaactat tcaacctgca
    35281 tttgatatga cattattagc tagttattat gcactatttg tatctgcgtt tatagtagct
    35341 acagtatcaa caatagtaac ggttaaattt atagaaccta aattaggtaa gtatactggt
    35401 aaaccagaag gtatagatga taatcaaggt tttgaggtca caaaagaaca agcaaaagca
    35461 gcaaagttag caggttttac agttttagct tatgtagcgt tattaattgc tttgtgtata
    35521 ccagctaata gttttttaag aagtccagaa ggttctttaa tatttggagc accacttatg
    35581 tcttgcttac agttttttat agtaatacta ttcttcttgc cagggattgt gtatggaatg
    35641 agggttggta aaatcaagac tgtaaaagac ttaaatgata tattatgtca atcaatggca
    35701 gcaatggcac cgtttatcgt acttgcaata gttataggtc aattcttaac gctattctca
    35761 gtgtctaatt tagcacaggt actagctata aaaggtggag cattactcaa ctcattgcca
    35821 ctaccaccac aagctataat actgctattc ttagtactag tagcgtttat aaatatattt
    35881 gttataagcg gaagtacaaa atggatgata tttggaccag tatttgttcc aatgttaatg
    35941 caattaaaca tacatccagc atttactcag tttgtatata gattaggaga ttctgtaacc
    36001 aatcatttat caccattaaa tgcattcttt ataatacttt tagcaacagt ccaaaaatac
    36061 gataaaaatg caggtatggg aactatattc tcagctatga taccttacac tataggttac
    36121 tttgtagtac ttgcagtttt agtagtagtt tggatgacaa taggtatacc agtaggaata
    36181 ggtggacaag tttggttata aaacatattt aataattttg ggaggaaaga aaatggaaac
    36241 aactgaaata agatacaatt ttgatgaagt aatagataga agtggaacaa actgtcttaa
    36301 atatgatctt aagagtcaat ttatgccaga atctccagaa gatgcactac cactatgggt
    36361 agcagatatg gattttgcat gtgcccctga gataattaat gcaatgcatg aaagaataga
    36421 cagaaaaata tttggatata gctctcaaca aactgatgat tattatgaag ctgtatgtgg
    36481 atggtttaag agaagatttg attggaaaat agaaaaagag aatatattct ttagcccagg
    36541 ggttgtgcct gcgttaggat ttttcacaca aatattaaca caaaagggtg atggtatcat
    36601 aatagaaaag cctgtatact atccttttga agataaaata actaataatg aaagaaaagt
    36661 agttaatagt cctttaaagt ttgaagatgg tcattattct atggattatg atggatttga
    36721 agaattagct aaagatgaaa ataataaggt gtttatatta tgtagtcctc ataatccagt
    36781 tggtagagta tggaaaaaag aagagcttag aaaaatagta gacatatgta agaaatatga
    36841 tttgtggata atatctgatg aaatacattg tgatattatt cgtaaaggtg aaaagcatat
    36901 accattagaa gtagcatgtc ctgattataa agatagaata ataacttgta cagctccaag
    36961 taagagtttt aacttagctg gtatgcaatt atcaaatata gtaatcaata ataaggaatt
    37021 acaaaaaaaa tggatgcttg aaacagattc taaattagct atattcctac ctaatccatt
    37081 cgcaatagtt gctactaaag ttgcttataa tgattgtgaa gattggatga atcaagtaaa
    37141 tgagtatata gatggtaata ttaaatatgt agaagatttt gttaatgagt atatgcctaa
    37201 agtaaagata ataaaatctc aaggaactta cttagtttgg ttagacttta gagggtatgg
    37261 attagatgca aaacagcttg aatatgtaat gcttaacaag gcgaaggtat tgctagatga
    37321 aggatacata ttcggagaag aaggagcagg atttgaaaga ataaatgttg cttcacctag
    37381 aacaattata gaagagtgta tgaatagaat aaaatgtgca tttgaaggat tataatagta
    37441 atatctaaat aatatatttg tgtattttaa aaaaagacta tgctaaaaaa atatttcaaa
    37501 gcatagtctt ttaaagtttt atgatgagtt taaaaaattt caaaacgtta ctattcactt
    37561 atatgtttat attagaaata attccacaat atactcattt tctaaagttg cacttttata
    37621 caccttgctt caccaatatc atgtgtaacc aaaatagtag acttattctc attcttaata
    37681 atactataaa catcatcaca aactaataat ctagtctgat aatcaagagc tgaaaaaggt
    37741 tcatctaaaa gtagaatatc tggatttaca gaaagtgttc taataagcgc aactctttgt
    37801 ctcatacctc cagataattc ttttggatac atacttctaa aatcccataa tccataagtc
    37861 tttaaaaggc tttcaactct atctaaagat tttttatctt ttttgccttg aatttccaat
    37921 ccaatagtta tattatccat tatatttctc cattcaagca aattatcttt ttgaaacata
    37981 tatccaatat ttccagtaat ctttatatca ccactagtcg gttttaaaag attagtaaga
    38041 atatttaata ttgtagattt accacttcca gaaggaccaa gcaaagttaa tatttctcct
    38101 tctttcaagt taaaattgac atcctttaat acttcaagct cgccttcctt agtgtagaag
    38161 ttcatattta tatttttaac ttctactatg ttgtcattca ttatgccacc ccctataact
    38221 tttagctcgt atatattatg ttattaacaa tatgacctat ttgtaccatt tttcataaat
    38281 ataatataaa tattttgttt atttacgtat tttcttagta acttgtacgt ataaattata
    38341 gataaataaa ttataaggta ggggataaat ttgagtaaca taataacgaa tttaatagag
    38401 tcaatattta ctaatccaat aactatattg tttttacttg caataactgt gtattctgtt
    38461 tttaaaataa tagaaaataa cagagtatat tcatttgtaa gttcaaaatt agacgaaatc
    38521 aatagagact ataagacaag tgagttttat aaaaaggtaa gggatgacta ctatacatat
    38581 agtaaagaaa atccttatgc agacgtaaat ataacttcat ttatagagga agttgtatct
    38641 gatttaaagc ataataattt gccattgtta gaaaaaatta gaagtataaa aaattcatct
    38701 tcaataagta tattacttgg ggttttaggt acgtttgttg gtctttctac aatgctttta
    38761 tgtgttgata ctaaagacat tataaattca cttccttcaa ctattagtag tatgcaaact
    38821 gcatttacaa ctagtatatt tggagttgta ttttctctaa ttataggtta ctttactaag
    38881 ataaaagatt gtgaacatgt tttgatacaa ataatgttaa aatctgaaaa tttactaaca
    38941 tctgaaataa ctcattttaa gtcagaaaga atggatttaa aagtagaaga ggtaaaaaat
    39001 acaataaaac aaataagtaa gtctatagaa gctattgaaa aatttgataa aatatctaaa
    39061 gatttaaatg actttaatga tgaatttatc agtggtatag aagctttaaa aagcctttta
    39121 gaaggttctc aaagttctat taagacattt gaccagagcg taagaaaatt agataaacag
    39181 tttaatattt taaatataaa atttgtaaag ctttttgata aatatgataa tcaagataat
    39241 ataaataaag agattttatt tgatataaaa gaatcttcaa aaaatatata caatgccact
    39301 gaaagccaat tcaaaattag agattatata aaaaatataa atgcaggatt tgctctatat
    39361 gaaagaagtg ctcaagattt attaactaaa ttaatgaccc atgaaaataa aatatctcaa
    39421 aatcaaaaaa tccttttaga tgaaaagttt accttagatg actcaataaa aaatctctca
    39481 agtattattg aaaacttttc taatgaccta caagttaaac tggatatgat gtttgaaaat
    39541 tctttagata ttcaagataa gttagatgtt atgtttaata actcttttat gaatgatgaa
    39601 gttcctcttg atagtgaaga attatttaag gatgatgtta ataatgtatt taatcctttt
    39661 agtgaagaaa tttatgagat agaggataaa gaaataaagg tcataggtga ggatgagtta
    39721 aatgaataat aaatatagaa gaactgttaa cagagaattt gaaaagagta gcttttggcc
    39781 aacatttaca gatttattat ctactgtatt gatggttgtg attcttatct tatttagctc
    39841 agaaagtatt tcaggttctg ttgaacaaga tttagctaag aatgtcaatg cttctgttga
    39901 agaaactttt aaaaaaagtg gaatacctgt gaaggtagat aaatctaatg ggcaagtaac
    39961 ttttggtgaa aaaaccatgt ttgatgtaga tagtgatgtt ttaaaaccag aggctaaaga
    40021 aatgctaaaa atgtttgttc caaagtacat agagactatt tataaagatt atggtgacta
    40081 tatatccaaa atagttatag aaggtcatac agatgatgtg ggaagttata tatacaactt
    40141 agatttatcg caaagaagag catatagcgt tgctaaattt atagtgggag atgaaatagg
    40201 tgactataaa tacaaagata aagtgactaa gcatattatt gcaataggaa ggtcaaaagc
    40261 tgaactcatc aaaaatggtg acaatagcgt gaatagagat gcatctagaa gagtagaact
    40321 aaaatacgaa ataaatatta atcaaaataa ataattaaat ttttataaaa aaaaagaagg
    40381 cagttggtgt gagctttaag ccttctttaa ggaaaaagtt tatttatttt tgttgatact
    40441 taacatatta tagtttttag aagcagtttg caatatatta aacgtaaatg gtcgtttaaa
    40501 atgcataact ggatactact gatgtaaaat atttcatttt atataatata aaaattatac
    40561 agtgtcaatt ttctatatta ttgtactata atctattatt taaaatatta tgtaaaaaaa
    40621 tatcataaaa acgcatatca tgttataatt actagagtat tatgaatatg gaggcgtagt
    40681 ttgtgataga aataagtata aaaaataaaa aaaattctaa aattaaaact ttgatacttt
    40741 tattgatagt atctatatcg atttatttaa ctggttgtac tacatcagat aatggaaata
    40801 atcaatcaaa taataatgat tctttgtcta gtagtatatc aagtgataag aatgtaaaaa
    40861 ttcattttat tgacactgga aatagtgatg caatattgat tcaagatggt aaaactttta
    40921 cattgataga tgggggagat aatgatgatg agggattaat ggtagattac ctaaacaatc
    40981 aaggtgtaaa agatattaaa tatcttatag ctacccattc tcatgcagac catttaggtg
    41041 gacttgattc tgttgtcaaa aactttaata tagaaaatgt ttttgtatcg aatggttcag
    41101 cagaaacaaa gagttatagg gactttataa atgctttagc aaataagggt ttatccccaa
    41161 gtgtaccgct tgaaaataat aagttctatt tagaagattc ttattttgaa gttctaaata
    41221 caaatggggg agatactact aatgaacaat ctctagtcct tgtatatact aatgggaatg
    41281 ataaagtttt atttacaggt gatgctgaag aaggtaccga aaaagaaata ctacctaagc
    41341 ttgagaaagt agacctttta aaagtagctc atcatggttc tcgtagtagt tcatctcaag
    41401 agtttttaga taaagtaaat cctgaatatg cggttctttt agtaggcaag ggtaattcat
    41461 atggtcatcc acatcaggag acaatgaata aattaaaaaa aatgggagta aaagtgcata
    41521 gaagtgatga gtgttcagat ataatatttg aatcaacagg tgatggagta tttacaagtt
    41581 gtaaagatgg aagttataat aaaggcgtta gagaagatgg aaactctgga aaatcaaaca
    41641 gtaatacaag taaaaatgat tcttttaaaa ataaacaaaa tacatccaat tcagaagaaa
    41701 tagtgtattt tactccaaaa ggtaagagct atcactctac aaaaaattgt agtgggcttt
    41761 caagaagtaa aaaaatatta tcaggcacaa ttgcagaaag taagaaaaat gacccatgtg
    41821 atatatgtta tggaaaataa caaaaaaaca accaatttat ctataaagct tctgaacttt
    41881 aaatcattta aaaaataaaa taaatgcata aaaaaataag ctataatcaa tagataacac
    41941 attttatcta tacgaatagc ttattttttt aagtattttt taatagctat ttaataactc
    42001 taaatacacc agttacaata cctacaattt caacttctga gtcattgagc ataattggtt
    42061 ccataaaatc attttctggc tgaagtctta ttaaatttcc ttctttaaaa aacctcttaa
    42121 ccgtagcaga ttcaccattt ataagtgcaa ctactatctg agaatttaag gctgtatttt
    42181 ttttgtctac tacaacgtaa tcttcatcta aaattcctgc attaatcata ctttcgcctt
    42241 ttactcttaa tacaaaattg ttactgccct ttactaaact ggcagggaat ggaatgtatt
    42301 cctctatgtt ttgttgagct aaaatgggtt ctccagctgt tatttgacct actaaaggaa
    42361 gctctattat ttcttgatta gctccagaaa catcatttac tttactacgt tctaaaactt
    42421 caatagctct tggtttagta gggtcctttc ttatgtatcc cagtttttca agtttattta
    42481 gatgagagtg cacagttgaa gtagatctta accctacagc agtacatatt tctcttacag
    42541 caggtggata accttttaat atgatttgag actttataaa ttccaatatc aagacttgct
    42601 tttcagttag atctaaatac ataacatcac tcatttccaa acatattttg tttttatttc
    42661 catacacttt atatttttaa ttataacata atccatttat atctgcaaac atttgttcct
    42721 gatttttaat cgtcctcaat ccattcaaaa ttcttgacta tatcacgttt tacatttttc
    42781 ttatgagctg cataaagctg agtagttgtg acattatcat ggtcaagtaa gttttgaaca
    42841 tcatatatag aaaatcctgt ttggattaga gaagttgcag ccgttgctct taatttatgg
    42901 ggactatatc cattgtctct agtagtatca agtggaatag atgtatattt ttttaccagt
    42961 gttcttatag cctttgctgt aattctctta ttttgaagag acaaaaataa agcatctttt
    43021 tcttcatcat ttaatagttc atctcttgtt ctttcgtttt gcaaataatc ttttattaca
    43081 tgttcacaag tatgatttat aggcattaaa acttctttcc cacgttttct atatatttta
    43141 aattcacctc ttgaaaaatt aaaagaggag atattgagtt ctctaagctc atttaatcta
    43201 agcccgtatg taacaaataa tgctagtata gctttgtcac gtaatttagt ttttctccaa
    43261 tatacctttt ctttctctgt aagcccttca cctgtttcta ctgattcaag catcttagca
    43321 acttcatcta tctcaaggcg cttaatagca tctggctgag gtttaggaag ttttattgga
    43381 ttgaatccat cagttatatt attatctatc tgagagtttc tgtataagaa tttaaataga
    43441 gtagagatgg atgatttttt tcttgctaaa gctctattgt tattttcaaa aatcaatgtg
    43501 tttttttctg tatttttgta atatctactg caataatcac ctaagaataa atttatatct
    43561 cttgatttta ttgtattaaa atcatcttct gtaatgtctt ttacacaatc tgcatttgtt
    43621 aattctttgg tttcaatcaa atatgaacaa aaaaaattaa tatcttctaa ataagcaagt
    43681 cgtgtagaaa ctgcaacaga accttttaaa tatataaaat aatccttcat aaatacagga
    43741 agtttatttt ccaaaagtag acatttttct atgagttcat tttctttgat aacaatatta
    43801 tcaggtttat ctgatttatt atgtactttt ataattttct tatcattatt caaaattaaa
    43861 cctcctaaaa ctaaaatata aatcttttat attatttttt gatatttata ctaagtgagt
    43921 ataaatattt aatttaatca ttttttacat ttttaagaga ttagcagtgc tttagatgaa
    43981 attatcacta actattccct aaatccacat
//
LOCUS       DAEHWM010000026        43633 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.027, whole genome shotgun sequence.
ACCESSION   DAEHWM010000026 DAEHWM010000000
VERSION     DAEHWM010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 43633)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43633)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43633
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.027"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            261..725
                     /locus_tag="KNP36_001470"
     CDS             261..725
                     /locus_tag="KNP36_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HBF0873351.1"
                     /translation="MATMTDIIEKFIKDLMEEDNSIQIQRNELANLFSCAPSQINYVL
                     TTRFTIDRGYYIESKKGGGGYVQIEKIRKSKDGHIRELLNEKIGSQISYKKAKELLEG
                     LKESDLINERELKLILYAIDDKSLCMPIYELKEKVRSNILKNIIIGLFSIEE"
     gene            732..1226
                     /locus_tag="KNP36_001471"
     CDS             732..1226
                     /locus_tag="KNP36_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UvrB/UvrC motif-containing protein"
                     /protein_id="HBF0873352.1"
                     /translation="MLCQKCNKNKASVYYNKIVNGEKTEMYLCSECAKENTEMNFNLD
                     MPFSMMDIFSNLGFQPKKELEEKLVCPKCNTTYSEFKNNGRFGCSECYNAFSSQVNPM
                     LQNIHGHIEHTGKAPKKSFYKISVENEIKELKEDLDRAIKNEEYELAAQFRDKIKYLK
                     GSID"
     gene            1242..2267
                     /locus_tag="KNP36_001472"
     CDS             1242..2267
                     /locus_tag="KNP36_001472"
                     /EC_number="2.7.14.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein arginine kinase"
                     /protein_id="HBF0873353.1"
                     /translation="MKENIVMKSRVRLARNLNNYPFPNKLDKECAMEIIEKVKNAFIN
                     SNLEQKEEFDFYKIEDLDQSKKMLMVEEHIISPDLAENDKSAVIVKKDKTISIMINEE
                     DHIRIQTICDDLNLEYAYSVANEIDDLLESSLEYAFNTKLGYLTSCPTNTGTGMRASV
                     MMHLPALSQLGYMDELYKISSQIGIAIRGIYGERTEALGNIYQISNQLTLGRTESNII
                     ENVSGLTKDAISKEIKAREILQKKLGIKLEDKIFRSIGTLENSRVMSSAEAMSHLSNI
                     KMGIEMNYIDKLDLRAIEQLMIGIQPAHQSIMYKSDDVENRDINRATYIRETLEKLRG
                     GMNCELQ"
     gene            2254..4701
                     /locus_tag="KNP36_001473"
     CDS             2254..4701
                     /locus_tag="KNP36_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HBF0873354.1"
                     /translation="MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEG
                     IAAKVLSKVGFTEAYLEGKIVDMEGKGEEISEDIVLSPRSKQILELSGMFANKLKTNY
                     IGTEHILLAIIQEGEGIANKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQ
                     NQAESKVLDKYGRNLTLYAKQNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVG
                     KTAIAEGLATNIALGNVPETLKNKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKN
                     GNIILFIDEMHTIIGAGSTGEGSIDASNILKPALARGEIQVIGATTIDEYRKHVEKDS
                     ALERRFQPVMVDEPTKEDSIKILEGLRDKYEAHHKVKITDDAIKAAVELSTRYISDRY
                     LPDKAIDLIDEAASKVRLKENTPPSEIKKLELEIENIDKEKEEAVRCQDFEKAAKIRD
                     EQGLLKKQLEDVRERWNKSSKHSDLVDGEVIAEVVGLWTGIPVNKILEEEADRLLRLE
                     EILHNKVIGQEQAVKSISKAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELSKALAEV
                     QFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVGHDEGGQLTEKVRRNPYSVILFDEI
                     EKAHPDVFNILLQILDDGRLTDSKGRTVDFKNTIVIMTSNVGASTIGRQKTLGFSIAK
                     GDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVFHSLNENHISKIVLLMAAKLQ
                     ERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQKELEDELSEAILKGNVKKG
                     SNVVAKVKDEKIVFETK"
     gene            4881..6254
                     /gene="radA"
                     /locus_tag="KNP36_001474"
     CDS             4881..6254
                     /gene="radA"
                     /locus_tag="KNP36_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HBF0873355.1"
                     /translation="MAKIKTKYVCQSCGYETAKWLGKCPECTKWNTFVEEIDQKSTKK
                     EVFIIDKSSSKPVSINSIESKEEERFTTDINELDRVLGGGIVKGSLVLVGGDPGIGKS
                     TLLIQVSSNVANLGKTVLYITGEESESQIKMRAKRLGINSEKLYIFAENNLSIIESYL
                     ESVNPELIILDSIQTVFSPEISSAPGTVSQIKEGTSKFMKISKKMGISTFIVGHVTKE
                     GSLAGPKLLEHMVDTVLYFEGERYNTYRLVRAVKNRFGSTNELGVFEMRDLGLVELDN
                     PSKILISEKPKDVAGSVIISTVEGTRPMLLELQALVSPTSFGIPKRTSTGVDYNRVGM
                     LLAVLEKRVGLQIQNQDVYINIVGGIKINEPSIDLGIAISVASSFRNIPIDEDIAVTG
                     EVGLTGEVRAVSFIEKRIAECKKLGFKKIVVPRSNYDVVKETKGIEIWPVDNLRQAIN
                     IVLGRNQ"
     gene            6257..7327
                     /gene="disA"
                     /locus_tag="KNP36_001475"
     CDS             6257..7327
                     /gene="disA"
                     /locus_tag="KNP36_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA integrity scanning protein DisA"
                     /protein_id="HBF0873356.1"
                     /translation="MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATN
                     EDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSE
                     TGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLE
                     KYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLV
                     SMQLEELMGTTRIDQKLIFKDYNKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSG
                     FSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDASIEELDEVEGIGEI
                     RATYIKNGLIKMKQLVLLDRHI"
     gene            7416..8510
                     /locus_tag="KNP36_001476"
     CDS             7416..8510
                     /locus_tag="KNP36_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIN/TRAM domain-containing protein"
                     /protein_id="HBF0873357.1"
                     /translation="MIRKVTRILFILLGFTIGITTYLTLMKDFEILTFGKETYGYIAA
                     VVAGIIIAILGYLIEPWVVNKVKEIAKIVDKELSKYPQTDILLGSMGLIVGFVIAYLL
                     SGLVNRIPIVGGILSLLLYLFLGYLGMKVALKSKNDLFNIGKLGRLANPIKDKDKDKE
                     NKKEVKAIPPKVLDTSVIIDGRIADICKTGFIEGKLIIPAFVLEELRHIADSSDDLKR
                     VRGRRGLDILNIIQKELNIEVEISERDFDDIAEVDSKLLKLAQVLNGKVVTNDYNLNK
                     VAQFQGVEVLNINELANAIKPVAIPGEDMVVQVVKEGKEAQQGVAYLDDGTMIVVDGG
                     RKYMNETIKVLVTSVLQTPAGRMIFAKPKN"
     gene            8639..10816
                     /locus_tag="KNP36_001477"
     CDS             8639..10816
                     /locus_tag="KNP36_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873358.1"
                     /translation="MRKKIISFLATFIIILTSASQYSFADDISTRGKVIFIDMNRTSM
                     SNMLRIKSLREELDNRGYIGLMNIRGDKGSDDRRSYASMGAGGRANVANEEDINFESS
                     SKDRNIVFESATGKSAKGINNLTINKSINENLNFGEYGSVLGSLGQSLSDNGLKASVL
                     GNSDIIENGQLIKNRNLCLTAMDEYGRIPNGNVDTINKKDLSMPYGISTDYDKLIVET
                     KEAYKNNDVIFVELGDTYRLDLYKPNLNEKTYESMKDNIEKNIDIYLKNIFSMVEEND
                     TVYIASAFPSDLDYKNKRRLSPIIKLNGEGKGILSSSTTRREGIVTNLDVGVEILDNF
                     NIKNQNMVGRKYELINRDDNKEFLMDEYQKIVSISSIRSTILNGFVSIVFLSWIVAMI
                     AILFRKHISKNYKETTFFILKELLKIGIVMPLSFMITPIMNFKTPLAISLGIIIITLT
                     IYLISKVLIKNDLKNMLFFTGLTIVIMVIDAGFGSYLMKSNVMSYDCIIGARYYGVGN
                     EYQGVAIGSAIFTFAILLTYKNIPKWSIIVFSLVILITSASPIMGANVGSAISECVAF
                     LLFILLIYNVKIDFKKIVLLGIAVVFVLGVFVAIDMILGSNSHLGMFVKEIYFNGPGE
                     IIQTFSRKIEMNLKLAQTSAWVNILLTGIGVILVLMINQIRYFKQLMDEYPIVFKGFI
                     ASIAGCLVTLLVNDSGIVSSATAFIYVIVPMITLSINLTALKE"
     gene            complement(10996..11847)
                     /locus_tag="KNP36_001478"
     CDS             complement(10996..11847)
                     /locus_tag="KNP36_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0873359.1"
                     /translation="MNRNNFSHEIIEPIDNLDVNFKLFDDSGSYVANHWHNSLEIIYI
                     TSGDLQINMEGYTYNLKANECMFINSGIIHSTRCIYQNTSILLQVPLSFLNKYIPDFK
                     NCYFDFKVNANDNNYKKNSSKVKLILENMREIKLSSPPAANLLFTSLLFELLFELYTN
                     FKISVGNKNMKKTVLDLSKFEPVLEYTKINYKMPISINKIAKVAHLQPEYFCRKFKQY
                     MGQTYLEYLNDVRISHIYKDLINTNDTLCSILEAHGFTNTKLFYRIFKEKFKCTPKHI
                     RKNLPKI"
     gene            12064..13230
                     /locus_tag="KNP36_001479"
     CDS             12064..13230
                     /locus_tag="KNP36_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="HBF0873360.1"
                     /translation="MYIKGVNLGGWLVLEKWMTSSLFEGTEAEDEYYLPRQLSREAYE
                     SRIKTHRSEYITERDFAMIKSMGFNSVRIPVPYFIFGDCEPFIGCVKELDKAFAWADK
                     YGLSILIDLHTVPGSQNGFDNGGISGICSWSQNPEYVAFTLNVLERLAKRYGMRHELY
                     GIQILNEPITERMWNIMNVPNRFKAVDKEMARGSKPNSLEFLRDFYIKAYKVMRPYMR
                     EENVIVFHDAFELKAWKDFMREEEFKNVVLDTHQYLMLAEADGCEQSIDSYLKYIREN
                     YAKDILQMQKYFPVICGEWSLFNSYACGIDTNGGQSPLNGIESNIDKLSKDDKRELYR
                     KIAKAQLDAWRNGSGHYYWNYKLLLDTVNEEGWIGWDSWDLVKCVAQEWYPIEY"
     gene            13252..14898
                     /locus_tag="KNP36_001480"
     CDS             13252..14898
                     /locus_tag="KNP36_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 43 protein"
                     /protein_id="HBF0873361.1"
                     /translation="MIKNPILPGFNPDPCICRKGDDYYLVVSSFEWFPGIPVYHSKDL
                     KNWELYTHILTDETKIDLKKLPSSKGIWAPCLTYCEEEDLFYIVYGIMNSMNARYFDV
                     DNYLITSKDIKGEWSEPVYLHSSGFDASIFHDDDGKKWIASLDWETREGYEKPGVICL
                     VEYCTKKKEIVGYPKRIWSGGTDRGCIEAPHITKRGDYYYIMCAEGGTGYGHSVTMGR
                     AKNIWGPYEKDSMNPIVTSIPGDFYERHDPDHLKPKYYNPESKLQKSGHGSYIETTSG
                     EVYLVHLTSRPFVPELRCTLGRETAIQKMKWTKDNWLRMEDESNLAKEYVSESKLEEH
                     LVSSIPSFDDFDSNELGLQYYAPRISPLSFADVKSRPGYVRIRGQESRTSLNKVSILA
                     RKLTSVYARITTKMEFYPEVHQHSAGLIMYYDNMNYINLRKYYSETLGQSALSIIHLE
                     NGEKTEFLNTRIPIKDIPIYLRLYVQGRKSYFEWSYDEKNYQRIGKVFDTTKFSDEYC
                     KYGEFTGTFIGLTCADRVKHKHYADFDFFEYIVDESKDVD"
     gene            14995..16368
                     /locus_tag="KNP36_001481"
     CDS             14995..16368
                     /locus_tag="KNP36_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0873362.1"
                     /translation="MNTEVNVKATTIRYEKISFFERISYGCGDLGCNIIYSAMSAFLL
                     FYYTNYADVSAAAVGSIMLVSRILDGFSDLTMGIIVDRTKSKYGKARPWILRMAIPFA
                     IAAVLLFSVPSNLGITSKLIYIFITYNLVSTVIYTAINVPYATLNSLITQNQYERGVL
                     SIFRMILATCGTLLINGLTLPLVEYFGNNLSAWTKTFFVFGIASIMVFFITFTGTKER
                     VKAVKQDRNEVIPFKIGIKSLFRNKYWIQITLCLVCIFIVFAINGGSSVYYAKFILGD
                     EKLFGPINMVSNISQIIAMFMVAPFIKKFGKRNVLIVGSIILISSNVMFIIVGQNHIG
                     VIFASAIKGIGSAGIASTMFAIVSDTIEYGEWKTGYRTEGLINSASSFGFKVGNGLGS
                     AILGAVLSIGGYVGTSATQSDLAIVSIKVCFIYLPIFITILQIIIMSFYKLDKEYSTI
                     LNELNTK"
     gene            16813..17766
                     /locus_tag="KNP36_001482"
     CDS             16813..17766
                     /locus_tag="KNP36_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HBF0873363.1"
                     /translation="MKKIGDLRLMMKCCSLYYEDNLNQQEIANQLGISRPTISRILKE
                     AFEQGIVKIQIVDVLKNDYQKIERSLERKYKLKEVIVVDDKQDALTQKQELARAVSEY
                     LTRVVKENDIIGVSIGTTLKEIPRYVEKSNCKNVTFIPLLGGIGDNEIDIHANQIAVS
                     LARAFGGDFKLLHAPAVMSDLSTKEKLCKDEKIKEVLDLIDKTTIAIVGIGNPMSLNS
                     TIMASGYMNEADIEDLKKYNSIGAICLQAFDKEGKTSILEFNQRVLGVKLEDLKKIKR
                     TIGVASGDEKIEAIKASLKAKFINSLAINHSLALKLLEDCD"
     gene            17804..18766
                     /locus_tag="KNP36_001483"
     CDS             17804..18766
                     /locus_tag="KNP36_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HBF0873364.1"
                     /translation="MSISKETLLEMYKRMNQARKFEEKVSWFFARGMVHGTTHLSVGQ
                     EASSVAAVMALEKGDLVSLTHRGHSQFIGMGIDLNKMMAELMGKETGFCKGKGGSMHI
                     ADIESGNLGANGVVGGGLTIAPGAALTQQYKKTGKIVLCSFGDGASNEGTFHEGINLS
                     SIWKLPIIFYCENNLYGMSTSIKRHMNIESIATRAASYGIEGISIDGYNPIEVYETVQ
                     KAAEKCRRGEGPVLIESRTYRWLGHSKSDANVYRTKEEIESWKAKDPIEFLKNYLIEN
                     NLSNEDELDKIQEFAKQSIEDAVEFAQNSPNPKIESLLEDVYAD"
     gene            18791..19777
                     /locus_tag="KNP36_001484"
     CDS             18791..19777
                     /locus_tag="KNP36_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HBF0873365.1"
                     /translation="MSTRELTYAQAIKEAMSEEMRRDENVIFMGEDIGIYGGAFGVSV
                     GMIDEFGPERVRDTPISEAAIAGAAAGAAATGLRPIMEVMFMDFVTISMDAIVNQAAK
                     MRYMFGGKAQVPMVVRCPGGSGTGSAEQHSQSLEAWFCHVPGVKVVAPSTPADAKGLL
                     KAAIRDNNPVIFVENKLLYRKKGFVPEDDYVIEIGKADIKREGTDVTVITYGRMLQSV
                     EEAAETLSKENINVEIIDLRTLYPLDKETIVKSVCKTGRVLICHEAAKTGGLGGEISA
                     LITESESFDYLDAPVKRICGKDVPIPYNPELEKAVVPRVDEIEEAIKSLIVR"
     gene            19790..20836
                     /locus_tag="KNP36_001485"
     CDS             19790..20836
                     /locus_tag="KNP36_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxo acid dehydrogenase subunit E2"
                     /protein_id="HBF0873366.1"
                     /translation="MVANKIKATPAARSQARKDNIKLDRLIGSGENGRIHLVDVLNYL
                     KDNKANTTPLARRIAEDLNIDLETIVGTGYNGKIRKCDVEKLTAKETIVSTNTSKSSE
                     KKELKIENENSSMFNTVEGIFEKPNPMRATVAKRMSESYFSAPVFTFNIEVDATELKV
                     LRAKLIDTVKESTGVKLTMTDLIVMAVSKILPNHQALNSAWTDEGIFRYKDVNIAIAV
                     GLDEGLYVPVVKNANKKSLKEIAKESKELAEKVKTGKLMPADQEGNTFTISNVGMYGI
                     TTFTPIINMPSSAILGVGATQDKFVPVNGEAKIKPIMNLSLTSDHRVIDGTVAAKFLK
                     DLKELLENPLSMLV"
     gene            21003..22733
                     /gene="lpdA"
                     /locus_tag="KNP36_001486"
     CDS             21003..22733
                     /gene="lpdA"
                     /locus_tag="KNP36_001486"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HBF0873367.1"
                     /translation="MSVEVIMPKAGVAMEEGTIVSWLKQEGEEVKIGEPILEITTDKV
                     NMEIESEGEGTLAVIIHKEEGEVLPVFTVIGVIAEKGENQEEVKAKYLSGNVSKEDIV
                     EENQNIEFKEEKINKKECNHDYDVVVIGGGPGGYLSALKAALLGGRVALVEENILGGT
                     CLNRGCIPTKTYIKTAEILEEIDQLSKRGVKVTVDKEQDIKKAIKYKNRVVKKLTAGV
                     GGLLKSRDVDVFNLKASVKEEHKVILSDGKVLDTENIIIATGSKVRILPIKGIESNLI
                     ITSTEALDLETVPEELVIIGGGVIGCEFAEIFNSRGSKVTIVEMEDRVIPRMDKELSE
                     SLKYSLSKKGINVLTKKKVSEFKEEGNNILVCIEGEEPIKADLCLYAIGREANLSGIE
                     DLDIKIDKGSIVVNSKMETSIPSIYAVGDVTGGVMLAHAAFKMGEVAASNALGVNKEV
                     DLGALPSCVYTIPEVASVGITEEDARKKYNVKVGKFNFAGNGRALASGQEQGYVKVVA
                     DAKYGEILGIHMFGCGVAELINHAASFKALEIPTDEASELIFGHPCTSEALMEALADV
                     NGECLHLPKK"
     gene            23151..26099
                     /locus_tag="KNP36_001487"
     CDS             23151..26099
                     /locus_tag="KNP36_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0873368.1"
                     /translation="MRQRIKNLIENEDKKNPLTDEAISSRLNIRREDVTFLRNELKIE
                     DSRQRRKVVLIKAIKDILKEEKTINKNDITRRLNSIGFTVSRFTVIQYLKEIQDSGDL
                     KLDKESDDKKEEIINNRENKDIAFDKLIGSSGSLSTIIKLAKAAILYPPHGLHTIIMG
                     PTGVGKSELAECMYKFAVESSRFPKNAPFIVFNAADYSENPQLLLSQLFGHVKGAFTG
                     ADENKEGLVSKADGGILFIDEIHRLPHEGQEILFQLIDKGMVRKLGETRLTHKIDVMI
                     ISATSEPIDSHLLNTFKRRIPVTIEIPELVARPLNERFDIINNFFLIEAQRMGANIHI
                     KSDVLKALMLYDCIGNVGQLRSDIQVACARGLLNQLTNKLKEVNISISDVPGYVKQGL
                     IKIRNCRGKIENYVDGDLIIDSNLQGEIEKKNEDIYTFPDEIYKLTERRHIDLLEQGL
                     DFDVINRIIGGELESCIQKYIKQVKKVSISNNLPDISPIVGKYIVELTYEVIKIASQY
                     LSSLEPNLHLCLAVHLKAAFERLKEGKVISNAHLKEIIGNYPLEYSVAEKVAQYLKER
                     YNINLPKEEIGIIAIYFKMSSRRDMSEQKKIGVLLMAHGRVASSVCEVTNKLLGINHA
                     RYLDMPFEKKPEEMIEEATTIIKDIDEGRGVIILVDMGSLSYFGDIISGKTGINIRTI
                     SRFDTLLSIEVIRRAVLPDLTIDEIVDEVKGIEPQVKEKVSKCNNTKVDFRKPIILTL
                     CITGLGGACKIKKILEENIKSITEKVDIEPIGMIEYPSLDLEIKQISNDKNVIAIVGT
                     IDPQIANIPFFSLVDINDKAKLNQINNLIDTNQIGETNKKYELSDLIHKEDIFVDLQV
                     KSKEEVLKYMSKKLREKGYVTKNFYKKVVERDNLFPTELSDEIAIPHTDGIDVIRPAI
                     SIAILKKPIVWSKSKVKIILLLAVDQKCFNPLSTLLSFIETDEFKKIKNIKDRDFIRE
                     MILDGVNENN"
     gene            26077..26541
                     /locus_tag="KNP36_001488"
     CDS             26077..26541
                     /locus_tag="KNP36_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0873369.1"
                     /translation="MESMKIISSNLIFKNIEVSNNEDALKFLGQRLFDEQYVKESYIQ
                     AVVAREKKYATGLPTEIYGVAIPHTDIVHVNEPGIAIGILNKPVKFIMMGTDDTEIDV
                     KVVFMLAVKEPQEQLQLLEKLMTIFQDKNILNNIVDLSEESVSDLLNSKLKN"
     gene            26654..26956
                     /locus_tag="KNP36_001489"
     CDS             26654..26956
                     /locus_tag="KNP36_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0873370.1"
                     /translation="MGVTNVAKKILVACGTGVCTSTIAINKLKKALQDIGKLDMVNIT
                     QCKVVEVASKAPDYDLIICTTQVSSSIKTPVINGLPFLTGVGMDKLINDVLEELEL"
     gene            27018..28382
                     /locus_tag="KNP36_001490"
     CDS             27018..28382
                     /locus_tag="KNP36_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425524.1"
                     /note="with GatAB forms a phosphoenolpyruvate-dependent
                     sugar phosphotransferase transporter for galactitol;
                     subunit IIC forms the translocation channel and contains
                     the substrate binding site; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBF0873371.1"
                     /translation="MEGLYMEILNFIVGLGAQVMMPIIICIFGLILGTKLGKSLRAGL
                     TVGVGFIGLNTIIALLTDNLGPATQQMVKNLGLSLSIIDVGWPAASAIAFASTVGALI
                     IPIGLVVNIVMLITNTTQTVDVDIWDYWHFAFTGALVAGATQSVMWGVFAAVANMVIV
                     LVMADLTAPGIEEYLGMPGISLPHGFTQAFVPIAIVVNKLLDLIPGINKIEINADTLQ
                     KKFGLFGEPLIMGSVIGVIIGIAAKYDIKGILQLGVTMGAVLILIPKMAALLMEGLLP
                     VSEAAQEFIEKRFKNRGKIYIGLDSAVGIGHPVTLSVALVLVPLTILIAAILPGNKVL
                     PFADLAVIPFALVLIVPITKGNVFRTLIIGIIIITSGLLIATNLAPLFTQMALNASFK
                     MPEGATMISSICDGANPLSWVFVKVMNYKVIGGVVFGVIALGMAIYNRNRIINENKKL
                     SIEE"
     gene            28417..28890
                     /locus_tag="KNP36_001491"
     CDS             28417..28890
                     /locus_tag="KNP36_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873372.1"
                     /translation="MKKYKYDSKRYLLSVTIPGFFMILILIYALFNNYTNFNLNIYSL
                     LIIVCTYGIFNTFISSSNPKKIIIDSKCIHFTSFMTTHKYEIKDIEKIRIREFYNKKI
                     YLKINDGKLFKGRYWIRTNMFNNSIALYSYFIELEECLYPDSLKFRNKKFENKNI"
     gene            29062..29712
                     /locus_tag="KNP36_001492"
     CDS             29062..29712
                     /locus_tag="KNP36_001492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HBF0873373.1"
                     /translation="MLLEKLRKEVLQASLDLLNYNLVTLTGGNVSGRDEQTGYIAITP
                     SGMDYRNLTPSDIVIVDVDGNIIDGKWKASVDLSDHLYIYKHREDINSIIHTHSTYSS
                     CFAILNEPIECASTTLANEVGGSVPVAKFSPPTSKKMGKCVIEAIGDKRACLLANHGV
                     IAVGPSVGHALTAAVMLEDSAKVYYLAKSIGTPVLLPDEEIQRARDVFFNVYGQDK"
     gene            29886..30818
                     /locus_tag="KNP36_001493"
     CDS             29886..30818
                     /locus_tag="KNP36_001493"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HBF0873374.1"
                     /translation="MYYLLNKSTNPYFNLALEEYLFLNDKYNDDIIIIWRNEESIFIG
                     KNQNPYQEVYHDVIEKGEIPILRRISGGGTVYHDLGNINMSFIQKDRQLHEIDFLEHT
                     KFMQKMLSTLGLDVSITERKDLFLNGKKISGSAQSIKRKNSLYHGTLLYDSDLNKLTK
                     YLNSNKATESNATKSVSSKVTNIKFLLEKDINYFLDYCVEYLKSNIKNIKELELDEED
                     IKSVYNIGEDKYKKIEWTYGKTPKFQVVLPFNNESKINIHVNRWKVSKFFISYDDNVI
                     NMDKLLDLNFFKEEIKESILENYPHYIDLINLIF"
     gene            31092..31805
                     /gene="ispD"
                     /locus_tag="KNP36_001494"
     CDS             31092..31805
                     /gene="ispD"
                     /locus_tag="KNP36_001494"
                     /EC_number="2.7.7.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HBF0873375.1"
                     /translation="MYSVIIVAAGSGRRMNLDINKQFIKLREKEIIAHTIQVFYENIN
                     IDEIVVCIKKEEEDFFKENIINKYNFKNIKIAYGGKERQDSIYNGLKKLDKNCDIVLI
                     HDGARPFVDHRIINESIKVAKEKKAVVVGVPVSDTIKIVSDGTVQETPERNLLWAAQT
                     PQTFEYNLIIDAYEQAYKNNYYGTDDSMLVENIGQSVTMVMGSYENIKITSPEDLNIA
                     EQILNMEKRDEVNSRRRII"
     gene            31802..32287
                     /locus_tag="KNP36_001495"
     CDS             31802..32287
                     /locus_tag="KNP36_001495"
                     /EC_number="4.6.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
                     synthase"
                     /protein_id="HBF0873376.1"
                     /translation="MRIGLGYDVHKLTEDRKLIIGGVEIPHDKGLLGHSDADVLIHAI
                     MDSILGALALGDIGKHFPDTDEEYKGADSMKLLEHVYNLITSKGYKIGNIDSTIIAQS
                     PKMAPYIESMRSNISKVLNTDIDNINIKATTEEGLGFTGAKQGIASQSICLLLLTSQN
                     N"
     misc_binding    32382..32590
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            32654..34369
                     /locus_tag="KNP36_001496"
     CDS             32654..34369
                     /locus_tag="KNP36_001496"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBF0873377.1"
                     /translation="MKMSKMFMPTLKEIPADAEITSHQLMVRSGMIKKMTSGVYNQLP
                     MGLRVFKKIEQIIREELNKKDCQEILCAALLPSELWKESGRWTAMGEEMFRLKDRTER
                     EYCLGPTHEEAFTDIIRQEITSYKQLPLNLYQIQVKYRDERRPRFGVMRTKTFTMKDA
                     YSFDVDDKGLDKSYQDMFDAYVSIFNRCGLENSPVQADSGAIGGSTSAEFMVKSEVGE
                     DEVVFCSGCDYAANVERAESCNLASQKEEMKELEEVHTPGAATIKELEEFLKTSPDKF
                     AKTLVYEADGKTVVVVVRGDREVNEIKVSNAIGSVIEFALATDDVVRKVTNAEVGFAG
                     PIGINADYVFIDKEIVEQRNIVVGANKTEYHIKNANYGRDFEGIVGDFRNVQEGDKCI
                     VCGKPLEIARGVEVGHIFKLGTKYSESMNANFIDKDGKSKPIVMGCYGIGVERTAAAI
                     IEQHNDEKGIIWPLSVAPYHVVIVPANMKNEEQISIAENIYNDLQAMGVEVLLDDRDE
                     RIGVKFNDSELIGIPMRITVGKNINEGKVEFKLRHKEDKEIIDIEEINEKVKAEFIRN
                     NVRLG"
     gene            34491..35936
                     /locus_tag="KNP36_001497"
     CDS             34491..35936
                     /locus_tag="KNP36_001497"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBF0873378.1"
                     /translation="MAKNEKQFVEEITKMEDDFPQWYTDVITKTDLVDYAPVKGFMVV
                     KPYGYALWEKMQEFMDKKFKETGHKNCYFPLLIPESLLNKEAEHVEGFAPEVAWVTHG
                     GNKKLEERLCVRPTSETIICTMYAKWLKSYRELPYLYNQWCSVVRWEKSTRPFLRTSE
                     FLWQEGHTLHETAEEAQEETIQQLEVYKALCEELLAMPVVAGQKSESEKFAGGERTYT
                     IEAMMHDGKALQSGTSHFLGQHFTKAFDITFADREGNLANPYHTSWGASTRLIGGLIM
                     THSDNRGLVLPPRVAPIQVVIVPIAAKKGNVMETVDKIYADLKAKGVAVEVDDRDNYT
                     TGWKFNEWEMKGVPVRVEIGPKDIENNQAMVFRRDTLEKDSMPLEGLADAICDLFDVI
                     HNDMFEKARKHREDNTSIVENMDEFRKALEEKPGFIKTMWCGDAECEAKIKEETGATI
                     RCLPFEQENLGHKCVYCGKEADSMVVMAKAY"
     gene            36374..37855
                     /locus_tag="KNP36_001498"
     CDS             36374..37855
                     /locus_tag="KNP36_001498"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HBF0873379.1"
                     /translation="MNVRVRFAPSPTGFVHIGSLRTALYNYLFAKKMGGEYILRVEDT
                     DQSRLVEGAIENMLNAMKWAGVNHSEGVILDDSGKVVQKGEYGPYIQSQRLDIYQEYI
                     KQLLDSGKAYYCFCTKERLDEVRDAQRAAGETAKYDGHCKNLSKEEVEANIKAGIPYV
                     IRLRLPENHTIKFTDLVRGDMEFNTNDLDDQVLMKTDGFPTYHFAVVVDDYLMKITHV
                     IRGEEWVSSTPKHVYLYEAFGWEAPVFVHLPNILNKEKKKLSKRQGDVAVEDFKKKGY
                     LPEGLVNYVALVGWSPEDNQELFTMEELEKAFSVERVSKSGGVFDTEKLNWVNQHYIK
                     DGDDAYLTDLAIPFLIEDGFITEEEATNKYDFLKSMISVLKEKLQYVKEVTEHASIFF
                     GDKIEVETEEGREFLRLEHIPTLIDALREKIEKTEVLNAEFVQAMLKEIQKEYKIKGK
                     NLFMGSRIILTGQMHGPDLPKVMEVLGKETCLNRIAYVKNNIL"
     gene            38076..38231
                     /locus_tag="KNP36_001499"
     CDS             38076..38231
                     /locus_tag="KNP36_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873380.1"
                     /translation="MYSNIDDVKKELKELCLEYVTILEKLKDEKMITEETFEKCSSQK
                     KIFLEEQ"
     gene            38376..39773
                     /locus_tag="KNP36_001500"
     CDS             38376..39773
                     /locus_tag="KNP36_001500"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HBF0873381.1"
                     /translation="MKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFI
                     IFDTLRRYLEYRGYDVTYVQNFTDVDDKIINRSHEEGISPEEVAAKYIKEYFVDCDGL
                     GIKRATVHPQVTDNIQQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQKQED
                     LEAGARIEVNDQKRHPMDFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGET
                     IDIHAGGQDLTFPHHENEIAQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVR
                     DISKLYDLEIVRFFMLSAHYRNPVNFSDEMLNQAKAGLERLYNTKEKLEFTLSNLVES
                     PLTEKEVELVKELDDFRQKFIDAMDDDVNTADAVSVIFELAKLINSNVDENSSLEFAK
                     KCLDEFNELTGVLNIVNKKKDTVLDKDIEELIQKRTDAKKNKEFQLADDIRQQLLDMG
                     IVLEDTRQGVKWKRI"
     gene            39758..40171
                     /locus_tag="KNP36_001501"
     CDS             39758..40171
                     /locus_tag="KNP36_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HBF0873382.1"
                     /translation="MEKDIKMEKTELVTMSPLVLAYLGDTVYETYIREYLIRQNTQRK
                     VNDLHKLAIKYVKAKAQATIIHEVEIELTEEESKIYKRGRNQKSNTSPKNADIIDYKH
                     ATGFEALVGYLYLNNEIERLQYIINKGIKIIERDM"
     gene            40277..41035
                     /locus_tag="KNP36_001502"
     CDS             40277..41035
                     /locus_tag="KNP36_001502"
                     /EC_number="2.1.1.148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent thymidylate synthase"
                     /protein_id="HBF0873383.1"
                     /translation="MKVKLISHTPEPEKVIAMAAKLCYSPVGTDEIEKDLTDESIEKF
                     LNMLLSIGHGSILEHASFTFSIEGISRACSHQIVRHRIASFSQQSQRYVKLEQFEYII
                     PPEIEKIEKAKELFIDSMKKDQENYDKLVEILFENHYNDLIKNGKNEKTAKRQAEKKA
                     IEDARYVFPNACETKMVFTINARSLFNFFEHRCCERAQWEIRNLAVEMLREVKKVAPI
                     LFKKTGPSCVNGSCPEGTMTCGDIVQVREKFKAL"
     gene            41048..41785
                     /gene="rlmB"
                     /locus_tag="KNP36_001503"
     CDS             41048..41785
                     /gene="rlmB"
                     /locus_tag="KNP36_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HBF0873384.1"
                     /translation="MASIEGRNPVIEAIKSDREIDKILIANSAKEGSIKKIIGMAKDK
                     NIIIQYVDKHKLDEVSTSHSHQGVIAYASEYKYYELDELIDLAKNKDEDPFFIILDEI
                     TDPHNLGSIIRTADAVGAHGVIIPKRRSVHITPVVAKASAGAVEYMPVCKVTNIVNTI
                     KRLKEEGLWIAAADMDGETFYKQNLTGPLGVVIGSEGFGISRLVKQNCDFIVKMPMIG
                     NVTSLNASVAGGILLYEIFRQRLDKSK"
     gene            41788..42315
                     /locus_tag="KNP36_001504"
     CDS             41788..42315
                     /locus_tag="KNP36_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NYN domain-containing protein"
                     /protein_id="HBF0873385.1"
                     /translation="MKKNINHYLIIDGYNIINAWDNLKELAKEDLEDSREKLIDDIIE
                     FSEFMGYKTIIVFDAYNVKNSREKVEKRKHITIVYTREHQTADSYIEKFITSLSKYDD
                     VKVATNDYAEQQMILGKGATRMSARELKLELDRSKNKMKEKNIGLRKKIQRNWLEERL
                     DKETLSKLENIRRKR"
     gene            42380..43027
                     /gene="sigH"
                     /locus_tag="KNP36_001505"
     CDS             42380..43027
                     /gene="sigH"
                     /locus_tag="KNP36_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigH"
                     /protein_id="HBF0873386.1"
                     /translation="MLVAKEKSYELVDNCQQDEYNIVLRASEGDKIALEYIITKYRNF
                     VKAKAKSYFLIGADKEDIIQEGMIGLYKAVRDFDGSKTNSFKCFAEICITRQIITAIK
                     TATRQKHIPLNSYVSLNKPIYDEESDRTLLDIIATSIVTDPEELIISKEELKNIESKM
                     NELLSDLELEVLELYLNGKSYQFIADKLKRDVKSIDNALQRVKRKLEKHLENRND"
     gene            43101..>43633
                     /locus_tag="KNP36_001506"
     CDS             43101..>43633
                     /locus_tag="KNP36_001506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-binding protein"
                     /protein_id="HBF0873387.1"
                     /translation="MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGE
                     AVDFANIDKAPEERERGITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDG
                     AILVCSATDGPMPQTREHILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLT
                     EYDFPGDDTPIVRGSAL"
BASE COUNT        17871 a         4541 c         8198 g        13023 t
ORIGIN      
        1 gtttagtaat aaagatgaga aggtatattt aaaatataaa gtatttaaag ttctgaaatc
       61 taatcatgaa gcaaaaaatt agcatttggt tatcaataaa tataataaat aaaaactcat
      121 aattaatgaa agaataaatt catatctaaa tttctataaa aaatttaaat ttatacaatt
      181 tagggcttta aaaatttaaa taataggtgt aaaataatag tcaaagaaag tcaaaaataa
      241 aaaggtgtgt ggtgatatta atggcaacta tgacagatat aattgaaaaa tttattaaag
      301 atttgatgga agaagataat agcatacaaa ttcaaagaaa tgaactagca aacttgttta
      361 gttgtgcacc atcacaaata aattatgtct taacaacaag atttacaata gatagaggat
      421 attacattga aagtaaaaaa ggtggcggag gatatgttca aatagaaaaa atacgaaaaa
      481 gtaaagatgg gcatattaga gaactactaa atgaaaaaat aggaagtcag atatcctata
      541 aaaaagcaaa agaattatta gaaggtttaa aagagtcgga tttgattaac gaaagagaat
      601 taaaattaat attatatgca atagatgata aatcattgtg tatgccaata tatgaattaa
      661 aagagaaggt aaggtctaat attttaaaga atataataat aggattattt agtatagagg
      721 agtgataatt tatgctatgt caaaaatgca ataagaataa agcatctgta tattataata
      781 agatagtcaa tggagaaaaa acagagatgt atttatgtag tgagtgtgca aaagagaata
      841 cagaaatgaa ttttaactta gatatgcctt tttcaatgat ggatatattt tctaatttag
      901 gttttcaacc taaaaaagaa cttgaggaaa agctagtttg tcctaaatgc aatacaacat
      961 atagtgagtt taagaataat gggagatttg gatgtagtga atgttataat gcatttagta
     1021 gtcaagtaaa tccaatgctt caaaatatac atgggcatat agaacataca ggaaaagcac
     1081 ctaaaaaatc tttttataag ataagtgtag aaaatgagat taaagaacta aaagaagatt
     1141 tagatagagc tataaaaaat gaagagtatg agttagcagc tcaatttaga gataaaatta
     1201 aatatttaaa aggttctatt gactaagatt ggagtgatat tatgaaagag aacatagtca
     1261 tgaaatcaag agttaggcta gctagaaatt taaataacta tccatttcca aataaattag
     1321 ataaagaatg tgccatggaa ataatagaaa aagtaaaaaa tgcgtttatt aattctaact
     1381 tagaacaaaa agaagaattt gatttctata aaattgaaga tttagaccaa tctaaaaaaa
     1441 tgcttatggt tgaagaacat ataataagcc cagatttagc agaaaatgat aaaagtgcag
     1501 ttatagtaaa aaaagataaa actataagta taatgataaa tgaagaagac catataagga
     1561 tacaaactat atgtgatgat ttaaacttag aatatgcata tagtgtagca aatgaaatag
     1621 atgatttgtt agaatcaagt ttagaatatg cctttaacac aaagctaggt tatctaacat
     1681 cttgtccaac taatacagga acaggaatga gagcttctgt aatgatgcat ttaccagcat
     1741 taagtcaact aggctatatg gatgaacttt ataaaatttc atcacaaata ggtatagcaa
     1801 ttagagggat atatggagaa cgaacagaag cgttgggaaa tatatatcaa atatctaatc
     1861 aacttacact tggaagaaca gagtctaata ttatagaaaa tgtaagtgga cttacaaaag
     1921 atgcaatttc aaaagaaata aaagctagag aaatattgca aaaaaaatta ggtataaaac
     1981 tagaagataa aatatttaga tcgataggga cacttgaaaa ttcaagagta atgagtagcg
     2041 cagaggcaat gagccatcta tcaaatataa aaatgggaat agaaatgaac tatatagata
     2101 aactagattt aagggctata gaacaactta tgataggtat acaaccagcg catcagtcaa
     2161 taatgtataa gagtgatgat gttgagaata gagatataaa tagagcaaca tatattagag
     2221 aaactttgga aaaattaaga ggagggatga attgtgaact tcaatagatt tacacaaaga
     2281 gctaaaaagg caattgattt agcgtttgaa tctgctaaaa gtctaggaca caatattgtc
     2341 ggaagtgaac atatactttt aggtctttta agagaagaag aaggtatagc tgctaaagtt
     2401 ctaagtaaag ttggatttac agaagcttat ttagaaggca aaatagttga tatggaaggt
     2461 aagggagaag aaatctcaga agatatagta ttaagtccaa ggagtaaaca aatacttgaa
     2521 ttatcaggaa tgtttgcaaa taaattaaaa acaaattata ttgggactga gcatatatta
     2581 ttagcaatta ttcaagaagg tgaaggaata gctaataaga ttttaaatta tgctggagta
     2641 aatgatagga ctttagccca attaacaatt gatatgatgg gtattagtga taaaaatcaa
     2701 tacaaagcag agaatagtta cacgggcaac cagaatcaag cagaatctaa agtacttgat
     2761 aagtatggaa gaaatcttac actatatgca aaacagaata aaatagaccc tgtaataggt
     2821 agagaaaaag aaatacaaag agtaatacaa atattaagta gaagaactaa aaacaatcca
     2881 gtgttgatag gagacccagg tgtagggaaa acagccatag ctgaaggtct ggctacaaat
     2941 atagccttag gaaatgttcc agaaacacta aaaaacaaaa ctttatactc tttagagatg
     3001 ggttcattat tggctggagc taagtataga ggagaatttg aagaaagaat taaagaagtt
     3061 gtagatgaag ttgttaaaaa tggaaacata atcttattta tagatgagat gcacacaata
     3121 ataggggctg ggtctactgg agaaggctct atagatgctt caaatatatt aaagccagcc
     3181 ttagcaagag gagaaataca agttataggt gcaactacaa ttgatgaata tagaaagcat
     3241 gttgaaaaag attctgctct agaaagaaga ttccaaccag ttatggtaga tgaaccaact
     3301 aaagaggact caataaaaat attagaagga ttaagagata aatatgaagc tcatcataaa
     3361 gttaaaataa ctgatgatgc tataaaggca gctgtagaat tatcaactag atatatatca
     3421 gacagatatc tgccagataa agctatagac ttgattgatg aagctgcatc aaaagtaaga
     3481 ttaaaagaaa atacacctcc ttcagaaata aaaaaattag aactagaaat agaaaatata
     3541 gataaagaaa aagaagaagc agtaagatgt caagactttg agaaagcagc caaaataaga
     3601 gatgaacaag gtctacttaa aaaacaatta gaagatgtta gagaaagatg gaacaagtca
     3661 tctaaacatt cagatttagt tgatggagaa gttattgctg aagtagtggg cttatggaca
     3721 ggaataccag ttaataaaat tcttgaagaa gaggctgata gacttttgag acttgaggaa
     3781 atactgcaca ataaagttat aggtcaagaa caagcagtaa aatctatttc aaaggcaatc
     3841 agaaggtcaa gagcaggtct taaagaccct aatagaccaa ttggttcatt tttattttta
     3901 ggtccaacag gagtaggtaa aacagaatta tctaaggcat tagcagaagt gcaatttgga
     3961 gatgaaaatc aaataattag aatagatatg tctgaatata tggaaaaaca tgctgtgtca
     4021 agaatgatag gttcacctcc aggttatgta ggtcatgatg aaggtggtca attaactgaa
     4081 aaagtaagaa gaaatccata ttcagttatc ttatttgatg agatagaaaa agctcatcca
     4141 gatgtattta atattctgtt acaaattcta gatgatggta gactaactga ttcaaaagga
     4201 agaactgtag attttaagaa tactattgta ataatgacat caaatgttgg agcatctaca
     4261 attggtagac aaaaaacttt aggatttagt atagctaaag gagacgaaga agaaaaatct
     4321 caatatgaaa aaatgaaaga aaatataatg ggtgaattaa aacaaagatt cagaccagag
     4381 tttttaaaca gaatagatga tataattgtt ttccactcac taaatgaaaa tcatatatca
     4441 aaaatagtac ttttaatggc agcgaaacta caagagagat taaaagaaat ggatataaaa
     4501 ttagaaatga gtgatgaggc tgttaaatta atttctaaat ctggatttga cttagaatat
     4561 ggagcaagac ctcttaaaag agctttacaa aaagagttgg aagatgagct atctgaagca
     4621 atcttaaaag gtaatgtgaa aaagggaagt aatgtagtag caaaagtcaa agatgaaaaa
     4681 atagtttttg aaactaaata atttaataga gttgcatttt aaaatattgc aaatataagt
     4741 tttataatct aaacaaaatt ttaagggcaa tgaatctata ataattcatt gtccttaatt
     4801 attttattta atctttacat attgtctttc agatatgcta aaattatagt atagaataaa
     4861 aaattaagga tgataaaagt atggcaaaaa taaaaacaaa atatgtatgt caatcttgcg
     4921 gatatgaaac agctaaatgg cttggtaaat gtccagaatg tacaaaatgg aatacatttg
     4981 tagaagaaat agaccaaaaa agcaccaaaa aagaggtctt tataatagat aaatcttcat
     5041 ctaaaccagt cagtataaac tcaatagaga gtaaagaaga agagcggttt acaacagata
     5101 taaatgaatt agatagagtg cttggaggag gtatagttaa aggctcttta gtgcttgttg
     5161 gtggtgaccc tggtataggt aaatcaacac ttttaatcca agtatctagt aatgttgcca
     5221 atttaggaaa aactgtttta tatataactg gagaagaatc agaatctcaa ataaaaatga
     5281 gagctaaaag attaggtatt aactcagaaa aattatatat atttgctgaa aataatttaa
     5341 gtataattga atcttattta gaaagtgtaa atccagaatt aataattcta gactcaattc
     5401 aaactgtctt cagtccagaa atatcctcgg caccaggaac tgtcagccaa attaaagaag
     5461 gtacttcaaa attcatgaaa atttctaaaa aaatgggaat ttcaacgttc atagttgggc
     5521 atgttacaaa agaaggttca ctagcaggac caaaattatt agagcatatg gttgatactg
     5581 ttctatattt tgaaggagaa agatataata cttatagatt agtaagagct gttaaaaatc
     5641 gatttggttc aactaatgaa cttggagtat ttgaaatgag ggatttagga ttagtagaac
     5701 ttgataatcc atctaaaatt ttaatctctg aaaaaccaaa agatgtagca ggttcagtaa
     5761 taatatctac tgtagaaggt acgaggccaa tgttacttga attgcaagca ttagtttctc
     5821 ctacaagttt tggtatacca aaaagaacat ctacaggagt cgattacaat agagtaggta
     5881 tgttattagc agtattagaa aaacgtgttg gtttgcaaat acaaaatcaa gatgtctata
     5941 taaacatagt tggaggaata aagataaatg aaccctcaat tgatttaggg atagccattt
     6001 ctgtagcatc tagttttaga aatataccga tagatgaaga tatagctgtt acaggagaag
     6061 tgggacttac aggagaagtt agagcagtaa gctttataga aaagagaata gctgagtgta
     6121 aaaaacttgg atttaaaaag atagtagttc ctagaagtaa ttatgatgtt gtaaaagaga
     6181 ccaaaggcat agaaatatgg ccagtagata acttaagaca agctataaat atagtacttg
     6241 ggaggaatca ataaatatgg agaattttct agataataaa aatatgctat atgcattaaa
     6301 aatgatatct cctggaactc cacttagatt aggtctaaac aatgtactaa gagctaagac
     6361 tggtggatta attgtaattg caacaaacga agatgtaatg aaaatagtag atggaggatt
     6421 tgctataaat gcagaatatt caccatcata tctatatgaa ttagctaaaa tggatggagc
     6481 tatagtttta agtggtgatg taaagaaaat attatttgct aatgcacaac ttatacctga
     6541 ctattttata gaaacatcag agacaggaac aagacataga acagcagaaa gagtagcaaa
     6601 acaaactggt gctatagtca taggaatttc acaaagaaga aatgttataa cagtttatag
     6661 aggaaatgag aagtatgtag tcgaagatat atctaagata tttactaagg caaatcaggc
     6721 tatacaaact ctggaaaaat ataagacagt attggaccaa gctgtaacaa atttaaatgc
     6781 cttagagttt aatgatttgg taactattta tgatgttgca ttagtcatgc aaaagatgga
     6841 aatggtaatg agagttacaa gtataattga aaaatatgtg atagaattgg gtgatgaagg
     6901 aactttagta agtatgcaat tagaagaatt aatgggtaca accagaatag accagaaatt
     6961 aatattcaaa gattataata aagaaaacac agaaataaaa gaacttatga aaaaggtcaa
     7021 aaatttaaat tcagaagaac taatagaatt ggtcaatatg gcaaaactat tagggtatag
     7081 tggtttttca gaaagtatgg atatgcctat aaaaacaaga ggttatagga ttcttagcaa
     7141 aatacataga ctaccaacag caataataga aaacttagta aattattttg aaaactttca
     7201 acaaatttta gatgcatcta ttgaagaatt agatgaggtt gaaggaatag gtgaaataag
     7261 agcaacatat ataaaaaatg gactcataaa aatgaaacaa ttagtcttat tagatagaca
     7321 catatgatga attttaaatg aattttacta cttttttctt gaatataata tacactttgg
     7381 tctataatag ataagtataa ctagggggtg aagcattgat aaggaaagta acaagaatat
     7441 tgtttatttt acttggattt acaataggta taacaaccta tttaacatta atgaaagatt
     7501 ttgaaatatt aacatttgga aaagaaacat atggttatat cgcagctgta gtagcaggta
     7561 taataatagc cattttagga tatcttatag agccatgggt tgtaaataaa gtaaaagaaa
     7621 ttgctaaaat agtggataaa gaattgtcaa aatatcctca gactgatata ttgttagggt
     7681 ctatgggtct tatagtagga tttgttattg cgtatttatt aagtggatta gtaaatagaa
     7741 taccaatagt aggtggaata ctatccttac tattatattt attcctagga tatcttggaa
     7801 tgaaagttgc gcttaaaagt aaaaatgatt tatttaatat tggaaaacta ggaagattag
     7861 caaatcctat taaggataaa gataaggata aagaaaataa aaaagaagta aaagccattc
     7921 ctccaaaagt attagataca agtgtaataa ttgatggaag aatagctgat atttgtaaga
     7981 ctgggtttat agaaggaaaa cttattattc ctgcttttgt tttggaggaa ctaagacata
     8041 ttgcagattc ttcagatgat ttaaaaagag taagaggtag aagaggtctg gatatattaa
     8101 atataattca gaaagaatta aatatagaag ttgaaataag tgagagagac tttgatgata
     8161 tagcagaagt tgatagtaaa ttattaaagc ttgctcaggt tttaaatgga aaagttgtta
     8221 caaatgatta taacttaaat aaagttgctc aattccaagg tgttgaagta ttaaatataa
     8281 atgagttagc taatgctata aaaccagttg ctataccagg tgaagatatg gttgttcaag
     8341 tggttaaaga aggaaaagag gctcaacaag gtgttgcata tctagatgat ggaactatga
     8401 tagttgttga tggaggaaga aaatatatga atgagactat aaaagtactc gttacttctg
     8461 ttcttcaaac tcctgcaggt agaatgatat ttgcaaaacc taaaaattaa tatgttcaaa
     8521 gaaacctata atttgggctg tttattttaa atagatggtc caaatttatt tatttataac
     8581 gataatgttt aatgtattct taaagatggg gatttaaatc agaaagcagg gagaatttat
     8641 gagaaaaaag attatatctt tcttagcaac atttatcata atattaacat cagcaagtca
     8701 gtatagtttt gcagatgata tatcaacacg tggaaaagta atatttatag atatgaatag
     8761 aactagtatg agtaatatgt taagaataaa atcattaaga gaagaactag acaatagagg
     8821 gtatattggc ttgatgaata taagaggcga taaaggaagt gatgatagaa ggtcatatgc
     8881 tagtatgggt gctggtggta gagctaatgt ggctaatgaa gaagatatta attttgaaag
     8941 ctcgagtaag gatagaaata tagtttttga atcagctaca ggaaaaagtg caaaaggtat
     9001 aaataattta actataaata agtctataaa tgaaaattta aactttggag agtatggttc
     9061 tgtattaggg tcattaggac aaagtttatc tgataatgga ttaaaagcat ctgtattggg
     9121 taattcagat ataattgaaa atggtcaact tataaaaaat agaaacttat gtctaactgc
     9181 aatggatgaa tatggaagaa tacctaatgg aaatgtagat actataaata aaaaagactt
     9241 atctatgcct tatggaatat caactgatta tgataaattg attgtagaga ctaaagaagc
     9301 ttacaaaaat aatgatgtga tttttgtgga gcttggagac acatatagat tagatttata
     9361 taaaccaaat ttaaatgaaa aaacatatga gagtatgaaa gataacatag aaaaaaatat
     9421 agatatatat ttaaaaaata tattttctat ggttgaagaa aatgacactg tctacatagc
     9481 aagtgcattt ccaagtgatt tagattataa aaataaaaga agactttcgc caataataaa
     9541 attaaatgga gaagggaaag gtatattatc atcttcaact actagaagag aaggtattgt
     9601 aacaaattta gatgttgggg ttgaaatatt agacaacttt aatataaaaa atcaaaatat
     9661 ggttggaaga aaatatgaac ttattaacag agatgataat aaagaatttt tgatggatga
     9721 atatcaaaag atagtatcta tttcaagcat aaggtctaca atactgaatg gttttgtaag
     9781 tatagttttc ttgtcatgga tagttgctat gattgcaatt ttatttagaa agcatatatc
     9841 aaaaaattat aaagaaacaa cattttttat attaaaggaa cttttaaaaa taggaatagt
     9901 aatgccactg tcatttatga taacaccaat aatgaatttc aaaacaccat tagcaatatc
     9961 tttaggaata attataataa cacttactat atatcttata agtaaagttt taataaagaa
    10021 cgatttaaaa aacatgctgt tttttactgg attaaccata gtaattatgg ttattgatgc
    10081 tgggtttggc tcatatttaa tgaaaagcaa tgttatgagt tatgattgta taattggagc
    10141 tagatattat ggagtaggaa atgagtatca aggtgtggca atcggtagtg caatatttac
    10201 atttgcaatt ttacttacat ataaaaatat accaaaatgg tctataatag ttttttcttt
    10261 ggttatctta attacaagtg catctccaat tatgggagca aatgttggaa gtgctatttc
    10321 tgaatgtgtt gcatttttac tatttatact attgatatat aatgtaaaga tagatttcaa
    10381 aaaaatcgta ttattaggta tagcagtagt atttgtatta ggagtttttg tagcaataga
    10441 tatgattttg ggaagtaatt cacatttagg catgtttgta aaagaaattt actttaatgg
    10501 accaggagaa ataatacaaa catttagtag aaagatagag atgaatttaa agctagctca
    10561 aaccagtgca tgggtaaata tactgttaac tggaataggt gtaattttag ttcttatgat
    10621 taatcagatt agatacttta agcaactgat ggatgagtat ccaattgtat ttaaaggatt
    10681 tatagcatca atagcaggat gtttagtaac tcttttagtg aatgactctg ggattgtgtc
    10741 atcagctaca gcctttattt atgtaattgt acctatgata acattaagta taaatcttac
    10801 agcattaaaa gaataagtac tgtatgaata atatgtaaat attaatacat taatttaact
    10861 tctttattta caaaataaag aagaaagttt ataaaaaata aattataata aaaaagagtt
    10921 tatctcaaaa ttgattattc taatcaaatt ttaagataaa ctctttttta ttataaagat
    10981 aaataacata taacttcata ttttaggtag attttttctt atatgtttag gagtgcattt
    11041 aaatttttcc ttaaaaattc tgtaaaataa ttttgtatta gtaaatccat gagcttctaa
    11101 tatactgcat aaggtatcat ttgtattaat taagtcttta taaatatgag aaatacgcac
    11161 atcatttaaa tactctaagt aagtttgtcc catatactgt ttaaattttc tacaaaaata
    11221 ttctggttgt aagtgtgcta ccttagcgat tttgttaata gaaataggca ttttgtaatt
    11281 aatctttgta tattctaaaa ctggttcaaa ttttgacaaa tcaagtactg tttttttcat
    11341 atttttatta cctacagata ttttaaagtt agtatataat tcaaataaaa gttcaaataa
    11401 taagcttgta aagagcagat tagctgcagg aggagaacta agtttaattt ctctcatgtt
    11461 ttctaatata agtttaactt tacttgaatt ttttttatag ttattgtcat tggcattaac
    11521 cttaaagtca aaatagcaat ttttaaaatc agggatatat ttgtttagaa aagacaatgg
    11581 tacttgcaat aatatagagg tattttgata aatacatcta gttgagtgaa taattccaga
    11641 attaatgaac atacactcat tagcttttaa attataagtg taaccctcca tgttaatttg
    11701 taaatcacca gaagttatat aaattatttc taatgagtta tgccaatgat ttgctacata
    11761 actaccacta tcatcaaata gtttgaaatt aacatctaaa ttatcaatag gttcaattat
    11821 ttcatgtgaa aaattatttc tgttcataat aatatcctcc ttataatttt aaattataaa
    11881 tagtaaattt ataatgttca atattaaaaa gataatatag attaataaat tagataataa
    11941 acatacttaa gaaaacggat aaaatcaaat ataataactg tatattaaaa taacttaaaa
    12001 aaattatttt attataagtg caaaatatac ctatttaaat aagataagag gggaggattt
    12061 tatgtgtata taaaaggtgt aaatttagga ggttggttag ttttagaaaa atggatgacc
    12121 tcaagtttat ttgaaggcac agaagctgaa gatgaatact atttaccaag acagctttca
    12181 agagaggcat atgaatctag aattaagact catcgtagtg aatacatcac agagagagat
    12241 tttgcaatga ttaaatctat gggatttaat tcagttcgta taccagtacc atactttatt
    12301 tttggagatt gtgaaccatt cataggatgt gttaaagaac ttgataaagc atttgcttgg
    12361 gcagataagt atgggcttag tatattgata gacttacata cagttccagg aagccaaaat
    12421 ggatttgata atggaggaat atcaggtata tgtagctggt cacaaaatcc agaatatgta
    12481 gcgtttacat taaatgtatt agaaagactt gcaaaacgtt atgggatgag gcatgaattg
    12541 tatggaatcc aaattttaaa tgagcctata acagaaagaa tgtggaacat aatgaatgtt
    12601 ccaaatcggt ttaaggctgt agataaggag atggcaaggg ggagtaaacc taattcatta
    12661 gagtttttac gtgattttta tataaaagca tataaggtaa tgcgtcctta tatgagggag
    12721 gaaaacgtta tagtatttca tgatgcattt gaattaaaag catggaaaga ctttatgaga
    12781 gaggaagaat ttaaaaatgt tgttctagat acacaccaat atttgatgtt agctgaagca
    12841 gatggatgtg aacaaagtat tgatagctat ctcaaatata ttagggaaaa ttatgctaaa
    12901 gatattttac aaatgcaaaa atattttcct gttatatgtg gggagtggag cttatttaat
    12961 tcatatgctt gtggtataga tacaaatgga ggtcaatcac ctctaaatgg gattgaatca
    13021 aatatagata aattatcaaa agacgataaa agagaattat ataggaagat agcaaaagca
    13081 cagcttgatg catggagaaa tggaagtggt cactactatt ggaattataa gttattacta
    13141 gatacagtta atgaagaagg ttggatagga tgggatagtt gggacctagt caaatgtgta
    13201 gctcaagaat ggtatcctat agaatattaa actaaaattg gaggaaaaga tatgattaaa
    13261 aaccctatac ttccaggttt taatccagat ccttgtattt gtagaaaggg agatgattat
    13321 tatcttgtag tttcatcttt tgaatggttt ccaggtatac ctgtttatca ctctaaagac
    13381 ttaaaaaatt gggagttata tactcatatt ttgacagatg aaacaaaaat agatttgaag
    13441 aagcttcctt catctaaagg aatttgggca ccctgtttga cttattgtga agaagaagat
    13501 ttattttata tagtttatgg aattatgaac tctatgaatg caagatattt tgatgttgat
    13561 aattatttaa ttacatcaaa agatataaag ggagagtgga gtgaaccagt atatctacac
    13621 tcatcaggtt ttgatgcgtc tatttttcat gatgatgatg gtaaaaagtg gattgcatca
    13681 ttagactggg agacaagaga aggatatgaa aaacctggtg ttatatgttt agtggaatac
    13741 tgtacaaaaa agaaagaaat agtaggatat ccaaagagaa tatggtcagg gggaactgat
    13801 agaggttgta ttgaagcacc acatataaca aagcgtggag attactatta tataatgtgt
    13861 gcagaaggtg gaactggata tggtcatagt gtaactatgg gaagggctaa aaatatatgg
    13921 ggaccttatg aaaaagattc aatgaatcca attgtaactt caattccagg cgatttttat
    13981 gaaagacatg accctgacca tctaaagcct aaatactata atccagaatc aaaacttcaa
    14041 aaatctggtc atggaagcta tatagaaaca acatcaggtg aagtatattt agttcatcta
    14101 acatctagac catttgtacc agagttaagg tgtactttag gtagagaaac agctattcaa
    14161 aaaatgaaat ggacaaagga taattggctt cgaatggaag atgaaagtaa tttggcaaaa
    14221 gaatacgtat cagaaagtaa actagaagaa catttagttt catctatacc aagttttgat
    14281 gactttgatt caaatgaatt aggtttacag tactatgctc ctaggatttc accattatca
    14341 tttgcagatg ttaagtctag accaggatat gtaaggatta gaggacaaga atcaagaaca
    14401 tcattaaata aagtgagcat attggcaaga aaattaactt cagtatatgc aagaataacc
    14461 actaagatgg agttttaccc agaggtacat cagcatagtg cgggtttgat aatgtattat
    14521 gataatatga attatataaa tttaagaaag tattatagtg aaacattggg tcaaagtgca
    14581 ctatcaataa tacatcttga aaatggagag aaaacggaat ttttaaatac taggatacca
    14641 ataaaagata taccaatata tcttcgtctg tatgtacaag gtcgtaagtc atattttgaa
    14701 tggagttatg atgaaaaaaa ctaccagaga ataggaaagg tatttgatac aactaagttt
    14761 tcagatgagt actgtaaata tggagaattt acaggtacgt ttataggatt aacttgtgca
    14821 gatcgtgtaa agcataaaca ctatgctgat tttgattttt ttgaatatat agtagatgaa
    14881 tcaaaagatg tcgattaata aaatcattac taaaattttc agagcaaagg taaatcttat
    14941 gctctgaaat aagaaacatt agaaggcaaa tcttacaaaa aggagtatgg tattatgaat
    15001 acagaagtta atgttaaagc aactacgatt agatatgaaa agatttcatt ttttgaaaga
    15061 atttcttatg gttgtgggga tttggggtgc aatatcatat actcagctat gtcagcattt
    15121 ttgctgtttt attatactaa ttatgcagat gttagtgcag cagctgtagg tagtattatg
    15181 cttgtatcta ggatactgga tgggtttagt gacttaacaa tgggaattat agtggataga
    15241 actaaatcca aatacggtaa ggctaggcct tggattttga gaatggcgat tccttttgct
    15301 atagcagcag tattattatt ttctgttcca tcaaatcttg gtatcacttc taaattaatt
    15361 tatattttta ttacatataa cttagtttct actgttattt atacagcaat caatgtaccc
    15421 tatgcaactc taaattcact tataactcaa aaccagtatg aaagaggagt attaagtata
    15481 tttagaatga tattagccac ttgtggtacc ttactaataa atggacttac actacctcta
    15541 gttgaatact ttggaaataa tttatcagca tggactaaaa cattctttgt atttggaata
    15601 gcatctataa tggtattttt tataacattt actggaacca aggaaagagt aaaagcagtt
    15661 aagcaagata ggaatgaagt aataccattt aaaataggta ttaaatcttt atttagaaat
    15721 aagtactgga tacaaataac attatgttta gtttgcatat ttattgtatt tgcgataaat
    15781 ggtggttcat ccgtatatta tgcaaagttt attttgggag atgaaaaatt atttggtcct
    15841 ataaatatgg tttcaaatat atcccaaatt atagctatgt ttatggttgc tccttttata
    15901 aaaaaatttg gaaaaagaaa tgtattaata gtaggttcaa taatattaat atcgtcaaat
    15961 gttatgttta taatagttgg acaaaatcat ataggagtaa tatttgcaag tgctataaag
    16021 ggaataggaa gtgctggaat agcatcaaca atgtttgcta ttgtttcaga tactattgaa
    16081 tatggagaat ggaagactgg atatagaact gaggggctta taaatagtgc atctagtttt
    16141 gggtttaaag tgggaaatgg attaggttca gcaatattag gtgcagtatt atcaattggt
    16201 ggttatgtag gaacatcagc tactcaaagt gatttagcta tagtatcaat aaaagtatgt
    16261 tttatatacc tacctatatt tataacaata ttacaaatta tcataatgtc tttttataag
    16321 cttgataaag aatatagtac tatacttaat gaattaaata ctaaataatg aaaaagtttc
    16381 ttataaagtc ttaagtttaa ttaaggtcta ttgtaaatgt tccctataaa aactattata
    16441 tatttatgat tattgaagaa tttttagaga agcgaataat aaaaatataa gaagacttta
    16501 aatgatgaaa tggttggttt tttagaagtg atttaataag ttattgttat ttaaagcatt
    16561 ataagtggac aattaatttt taatttatgg agatgatatt taacaattag aagtaatata
    16621 taatatgcac taagaagcaa tttttcaact atttatgaag gtggtggtac aagaaaagta
    16681 tcaccttttt tttgttatac aaaaaaacag ttgacttttt atatgaaccc cttctataat
    16741 gttactgaaa ttaagtaaaa tgattgaaca aatgtaaaga taattgaaaa gcttgatttt
    16801 ggaggaaagc aaatgaaaaa aattggagac ttaagattaa tgatgaagtg ttgttcactt
    16861 tattacgaag ataatttgaa tcaacaggaa atagcaaatc aattgggaat atcaagacca
    16921 acaatatcaa gaatattaaa agaagctttt gaacaaggaa tagtaaaaat acagatagtt
    16981 gatgttttga aaaatgatta ccaaaaaata gagagaagtt tggagagaaa atataaatta
    17041 aaagaagtaa tagtagtaga tgataaacag gatgcactaa cacaaaaaca agaactagca
    17101 agagctgtat ctgaatattt aactagagta gtaaaggaaa atgatataat aggtgtttca
    17161 ataggaacaa cactaaaaga aataccaaga tatgtggaaa aaagtaactg taaaaatgtt
    17221 acatttatac ctctattagg agggattgga gacaatgaaa tagatattca tgcaaatcaa
    17281 atagccgtaa gtttagcgag ggcttttgga ggtgatttta aattattaca tgctccagct
    17341 gttatgtctg acttgtctac aaaagagaaa ctttgcaaag acgaaaaaat taaagaagta
    17401 ctagatttaa tagataaaac aactatagca attgtgggta taggaaatcc tatgagttta
    17461 aactcaacaa taatggcttc tggatacatg aatgaagcag atatagaaga tttaaaaaaa
    17521 tacaactcaa taggtgcaat ttgtttacaa gcctttgata aagaaggaaa aacttctata
    17581 cttgaattta atcaaagagt attaggagtg aaactggaag atttaaaaaa gataaaaaga
    17641 acaataggtg tcgcttcagg agatgaaaaa atagaggcaa taaaggcatc attaaaagcg
    17701 aaatttataa atagtttagc aattaatcac agtttagcac ttaaattatt agaagattgt
    17761 gactaataga aagatagata aaagttaaca ggagggaatg tatatgtcaa tatcaaaaga
    17821 aacattgctt gaaatgtata agagaatgaa tcaggctaga aaatttgaag agaaagttag
    17881 ttggtttttt gcaagaggta tggttcatgg aacaactcac ttatctgtag gtcaagaagc
    17941 gtcaagtgtg gcggctgtaa tggctttaga aaaaggagat ttagtatcat taactcatag
    18001 aggacatagt caatttatag gaatgggaat agacctaaat aaaatgatgg ctgaacttat
    18061 gggtaaagaa actggatttt gtaagggaaa aggaggctca atgcatatag cagatattga
    18121 gtcaggtaac ttaggagcaa atggagttgt aggtggaggt cttacaatag ctccaggagc
    18181 tgcacttaca caacagtata aaaaaacagg caaaatagtt ttatgtagtt ttggtgatgg
    18241 agcatcaaat gaaggtactt ttcatgaagg aataaattta tcttcaatat ggaaattgcc
    18301 aataatattt tactgtgaga ataatttata cggtatgtca acaagcataa aacgtcatat
    18361 gaatatagaa agtattgcca ctagagcagc ttcttatgga atagaaggaa tatcaataga
    18421 tggatataac ccaatagaag tatacgaaac agtacaaaaa gctgctgaga agtgtagaag
    18481 aggagaagga cctgtattaa ttgaaagtag aacttataga tggttaggtc attcaaaatc
    18541 agatgcaaat gtatatagaa caaaagaaga aatagaatca tggaaagcaa aagaccctat
    18601 tgaattttta aaaaattatc ttatagaaaa taatctatct aatgaagatg aattagataa
    18661 gattcaagaa tttgcaaagc aatcaataga agatgcagta gagtttgctc aaaatagccc
    18721 aaatccaaaa atagagtctt tattagagga tgtatatgca gactaagaat ggtaaaggag
    18781 gaaaataaaa atgagtacaa gggaattaac atatgcacaa gcaataaagg aagcaatgtc
    18841 agaagaaatg agaagagatg aaaatgtaat atttatggga gaagatatag gaatatatgg
    18901 aggagcattt ggtgtatcag ttggtatgat agatgaattt ggaccagaaa gagtaaggga
    18961 tactcctata tcagaagcag ctatagcagg agcggcagca ggtgcagcag caactggctt
    19021 aagacctatt atggaagtaa tgtttatgga ctttgtaaca atttctatgg atgcaattgt
    19081 aaatcaagcg gcaaaaatga gatatatgtt tggaggaaaa gcacaagttc caatggttgt
    19141 tagatgccca ggaggttctg gaactggttc agcagagcaa cattcacaaa gtttagaagc
    19201 ttggttttgt catgtaccag gagtaaaagt agttgcacct tctacaccag cagatgctaa
    19261 gggattgttg aaagcagcta taagagataa taatccagtc atatttgttg agaataaatt
    19321 gttatacaga aaaaaaggtt ttgtgccaga agatgactat gtaattgaaa ttggaaaggc
    19381 agatattaaa agagagggta ctgatgttac agtaattact tatggaagaa tgttacaaag
    19441 tgttgaagaa gcagcagaga ctctatcaaa agaaaatata aatgttgaaa ttatagattt
    19501 aagaacttta tatccattag ataaagagac tatagtaaag agtgtatgta aaactgggag
    19561 agttttaatt tgccatgaag cagctaagac tggtgggcta ggtggagaaa tatcagcact
    19621 gataacagaa agtgaatcat ttgattattt agatgctcca gtaaaaagaa tttgtggaaa
    19681 agatgtgcca ataccatata atccagagtt agaaaaagca gttgtcccaa gagttgatga
    19741 aatagaagaa gcaataaaat ctttaattgt tagataagga gggatagata tggtggcaaa
    19801 taaaataaaa gccacaccag cagctagaag tcaggcaaga aaagacaata taaaattaga
    19861 taggctgatt ggaagtggag aaaatggaag gattcattta gtagatgtgt taaattattt
    19921 aaaagataat aaagcaaata ctactccttt agctagaaga atagcagaag atttaaatat
    19981 agatttagaa actattgtag gtactggata taatggaaag ataagaaagt gtgatgtgga
    20041 aaaattaact gcaaaagaaa ctattgtatc gactaataca tctaaatcta gtgagaaaaa
    20101 agagctgaaa attgaaaatg aaaattcaag catgtttaac acagtagaag gaatatttga
    20161 aaagccaaat ccaatgagag ctactgtagc aaaacgaatg tcagaaagtt attttagtgc
    20221 tcctgtattt acattcaata tagaagtaga tgctacagaa ttgaaggtac ttagagcaaa
    20281 gttaatcgac acagtaaaag aatcaactgg agtaaaatta actatgacag atttaatagt
    20341 aatggcagta tctaaaatac ttccaaatca tcaagcctta aattcagcat ggacagatga
    20401 gggtatattt agatataaag atgtaaatat agctattgca gttggtttag atgaaggctt
    20461 atatgttccg gtagtaaaaa atgcaaacaa aaagtcttta aaagaaatag caaaagaaag
    20521 caaagaactt gcggaaaaag taaagacagg gaaacttatg ccagcagacc aagaaggtaa
    20581 tacatttaca ataagtaatg ttggaatgta tggtataact acatttacac ctataataaa
    20641 tatgccttca agtgcaatct taggggtagg tgctacacaa gataagtttg ttccagtaaa
    20701 tggagaggct aaaataaaac ctataatgaa cttatcatta acatcagacc atagagtaat
    20761 agatggaaca gtagctgcaa aattcttaaa agatttaaaa gaattgttag aaaatccttt
    20821 atcaatgctt gtataggttt tgatattttg ttactgatat aaatagtttg aatagattat
    20881 attattataa ttgtttcagt aaatttaaag cttttatata ttaagaatta tttttaacag
    20941 taactatatg tgaatatgat ttgcttaatt aaaatataag aaaataaata ggaggagagc
    21001 ctatgtcagt agaagtaata atgccaaaag caggagtagc catggaagaa ggtactatag
    21061 tatcttggct aaagcaagaa ggcgaagaag taaagattgg agaacctata ctagaaataa
    21121 caacagataa agttaatatg gagatagagt cagaaggaga aggtacactt gctgtaatca
    21181 tacataaaga ggaaggtgaa gtattaccag tatttacagt aataggtgta atagcagaaa
    21241 aaggggaaaa tcaagaggaa gtaaaagcta aatatttatc tggaaatgtt tcaaaagaag
    21301 atatagttga agagaatcaa aatatagaat ttaaagaaga aaaaataaac aaaaaagagt
    21361 gtaatcatga ttatgatgta gtggtaatag gaggaggacc tgggggatat ttatcagcat
    21421 taaaagcagc tcttttaggt ggaagagttg ctttagttga agaaaatata ctaggaggta
    21481 cttgcttaaa tagaggttgt atccctacaa agacttatat aaaaacagca gaaatattag
    21541 aagaaattga ccaattatca aagagaggtg taaaagtaac tgtagataaa gaacaggaca
    21601 ttaagaaggc cataaaatat aaaaatagag tagttaaaaa acttacagct ggtgttggcg
    21661 gattattaaa aagtagagat gtagatgtgt ttaatcttaa agctagtgtt aaagaagagc
    21721 ataaagtaat tttatcagat ggaaaagttt tagatacaga aaatataata attgctacag
    21781 gttccaaagt aaggatatta cctataaaag gaatagaatc aaatttaata ataactagta
    21841 cagaagcatt agatttggaa acagtgccag aagaattagt aataattggt ggtggagtga
    21901 ttggttgtga atttgcagag atattcaatt caagaggttc taaagtaact atagtagaaa
    21961 tggaagatag agtaatccca agaatggata aagagttaag cgaatcttta aaatattctc
    22021 ttagtaaaaa aggtataaat gtattaacta aaaagaaagt ttctgaattt aaagaagaag
    22081 gaaataacat attagtgtgc attgaaggtg aagagccaat aaaagcagat ttatgtctat
    22141 atgctatagg aagagaagct aatctttctg gcatagagga cttagatatt aaaatagata
    22201 aaggttcaat agttgtaaat agtaaaatgg aaacaagtat accaagcata tatgcagtag
    22261 gtgatgttac tggaggtgta atgttagctc atgctgcttt taaaatggga gaggtagcag
    22321 cttcaaatgc tctaggtgtg aataaagaag ttgacttagg tgcattacct agttgtgttt
    22381 atacaattcc agaagtagca tcagttggta ttacagaaga ggatgctaga aaaaaatata
    22441 atgtaaaagt tggtaagttt aattttgctg gaaatggaag agctttagct tctggtcaag
    22501 aacaaggata tgtgaaggta gtagcagatg ctaaatatgg agaaatttta ggtatacata
    22561 tgtttggatg tggtgtagca gaacttataa atcatgcagc atcatttaaa gcattagaga
    22621 tacctactga tgaagcaagt gagttgatat ttggtcatcc atgtacttca gaagctttaa
    22681 tggaagcttt ggcagatgta aatggagaat gtttacactt acctaaaaaa taaatctaaa
    22741 cataaattat taatttaagt ctattattaa tattaattta tatcataaaa ttttaaaaca
    22801 cttacttagc catacccctt attatgcaaa taatttattt gcataataag gggtattttt
    22861 tatggaaaaa tatagaatat agaatccttg tagtttttgt tgtacaaaaa agatagtaat
    22921 ataaaataac attatcattt tagaatgatt tcaattgtaa ttaggaaaag tgattttttt
    22981 gtttttaaaa aaagtattat ttgtaaaata taaaaaaaaa tttcttaata tttaaataaa
    23041 agaatagctt aatttaaatg ttattacttt ataaaaaaat aataagtaca aaaaaaacaa
    23101 tatatggcat ataagttgct atataaataa taaggaggga acaattataa atgaggcaaa
    23161 gaataaaaaa cttaattgaa aatgaagata agaaaaatcc tttaacagat gaagcgattt
    23221 caagtaggtt aaatattcga agagaagatg ttaccttttt gagaaatgag ttaaaaatag
    23281 aagattcaag acaaagaaga aaagttgttt taattaaagc tataaaagat attttaaaag
    23341 aagaaaaaac tataaataaa aatgatataa caagaagatt aaacagcatt gggtttacag
    23401 tatcaagatt tacagtcata caatacttaa aagagattca agattctggt gacctaaaac
    23461 ttgataaaga gagtgatgat aaaaaagaag aaataatcaa taatagagaa aataaagata
    23521 tagcatttga taaactcata ggtagtagtg gtagcttaag tacaattata aaactagcca
    23581 aagcagcaat tctttatcca cctcatggtc ttcatactat tattatgggg ccaactggtg
    23641 ttggaaagag tgagttagca gagtgtatgt ataaatttgc agtagaatca tccagattcc
    23701 ctaagaatgc accatttata gtttttaatg cagcagatta ttcagagaat ccacagcttt
    23761 tgctatcaca gttatttgga cacgttaaag gtgcttttac aggagctgat gagaacaaag
    23821 aaggattagt atcaaaggca gatggaggaa tattgtttat agatgaaata catagattac
    23881 ctcatgaagg tcaagaaata ctatttcaac tgattgataa aggtatggtc agaaagttag
    23941 gagaaacaag actaacacat aaaatagatg taatgattat ttcagcaact tctgagccaa
    24001 tagattctca tttacttaat acatttaaaa gacgtatacc tgtaacaatt gaaataccag
    24061 aattagttgc aagaccatta aatgagaggt ttgacattat aaataatttc ttcttaatag
    24121 aagctcaaag aatgggagca aacatacata taaagtcaga tgtattaaaa gctcttatgc
    24181 tttacgattg tataggtaat gtaggtcaac ttagaagtga tattcaagta gcttgtgcta
    24241 ggggactatt aaaccaactt acaaacaaac taaaagaagt aaatataagc atatcagatg
    24301 tacctggata tgtaaaacaa ggtcttataa aaatcagaaa ttgtagagga aaaatagaaa
    24361 attatgtaga tggggattta attatagact caaatcttca aggtgagata gaaaagaaaa
    24421 atgaagatat atatactttt ccagatgaaa tatacaaact tactgaaaga agacatattg
    24481 atttattgga acaaggttta gattttgatg ttataaatag aatcattgga ggagaattag
    24541 aaagttgcat tcaaaaatac ataaaacaag ttaaaaaagt ttctattagt aacaatcttc
    24601 cagatataag tccaattgtt ggaaaatata tcgtagagct aacttatgaa gtaatcaaaa
    24661 tagcatcaca atacctaagt tcactagaac cgaatctaca tttatgttta gcagttcacc
    24721 taaaagcagc ttttgagaga ttaaaagaag gaaaagtaat atcaaatgct catttgaaag
    24781 aaataatagg aaattatcca ctagaatatt ctgtagcaga aaaggtagct caatatttaa
    24841 aggaaagata taacataaac ttaccaaaag aagaaatagg tataatagca atatatttta
    24901 aaatgagtag tagaagagat atgtctgaac aaaaaaagat aggtgtactt cttatggctc
    24961 acggaagagt agcatcttct gtatgtgagg ttacaaataa actattagga attaatcacg
    25021 caaggtattt agatatgcca tttgagaaga aaccggaaga aatgattgaa gaagctacta
    25081 caataataaa agatattgat gaaggtagag gtgtgattat attagtagat atgggttcac
    25141 tttcatattt tggagatatt atttctggaa agactggaat taatataagg acaatatcta
    25201 gatttgatac attgctttct atagaggtta tacgaagagc agttttacca gatttaacaa
    25261 tagacgagat agttgatgaa gttaaaggta tagagccaca agtaaaagaa aaggttagta
    25321 aatgtaataa tacaaaagta gattttagaa aacctataat tttaacatta tgtattactg
    25381 gattaggggg agcttgtaag ataaaaaaaa tcctagagga aaatattaaa agtataactg
    25441 aaaaggttga tatagaacct ataggtatga ttgaatatcc aagtcttgat ttagagataa
    25501 aacaaataag caatgataaa aatgtaatcg ccatagttgg aacaattgac cctcagatag
    25561 caaatatccc tttttttagt ctagtagaca taaatgataa agcaaagtta aatcaaataa
    25621 ataacctaat tgatacaaat caaattggtg aaacaaataa aaaatatgaa ttatcagatt
    25681 taatacataa agaagatata tttgtggatt tacaggttaa atcaaaagaa gaagttctaa
    25741 aatatatgag taaaaaactt agagagaaag gttatgtgac aaaaaatttc tataaaaaag
    25801 tagtggaaag agataactta tttccaactg aattatcaga tgaaatagca atacctcaca
    25861 cagatggaat agatgtaatt aggccagcta taagtatagc catcttaaag aagcctattg
    25921 tgtggagtaa aagtaaagta aaaataatac ttttattagc tgtagaccaa aagtgtttta
    25981 atccattaag cactctactc tcatttatag aaacagatga atttaagaag ataaaaaaca
    26041 ttaaagatag agattttatt agggagatga tattagatgg agtcaatgaa aataattagt
    26101 agcaatttaa tttttaaaaa tattgaagtg tctaacaatg aagatgcatt aaagtttttg
    26161 ggacaacgtt tgtttgacga acagtatgta aaagaaagct acatacaagc tgttgtagca
    26221 agagaaaaaa agtatgctac agggttacca acagaaatat acggagtggc aataccacat
    26281 acagatatag tacatgtaaa tgagccagga atagcaattg gaatactgaa taaacctgta
    26341 aaatttataa tgatgggtac agacgatact gaaattgatg taaaagttgt atttatgtta
    26401 gcagtgaaag agccacaaga acaattgcaa ctattagaaa aacttatgac tatatttcaa
    26461 gataagaata tactaaataa tattgttgac ttaagtgaag aaagtgtgag tgatttatta
    26521 aactctaaat tgaaaaatta aacatgtaaa gtatattaaa aatgtaaaat taaacatgca
    26581 aagtatgtta aaaaatataa aaagattatt aaagatttct aactatagat atctttaaaa
    26641 taaaataatt tcaatggggg tgactaatgt ggctaaaaag atattagttg catgtggaac
    26701 aggagtatgt acttcaacaa ttgctataaa caaattaaag aaagcacttc aagacattgg
    26761 taaattggat atggttaata ttacacaatg taaagtagta gaagttgcat caaaagcacc
    26821 tgattatgat ttaataattt gtactacaca agtatctagt agtataaaaa caccagtgat
    26881 aaatggatta ccttttttaa ctggtgtcgg aatggataaa ttaatcaatg atgtattaga
    26941 agagttagaa ttataattaa aaaaattaag gaacatggtc tctaaaatca taagttttag
    27001 agacttaaaa ttaaataatg gagggtcttt atatggagat attaaatttc attgttggtc
    27061 taggtgcaca agtaatgatg ccaataataa tatgtatttt tggtttgata ttaggtacaa
    27121 aactaggaaa atctttaaga gctggtttaa ctgtgggagt tgggtttata ggtcttaaca
    27181 ctattatagc tttgctaaca gataatttag gtccagctac acaacaaatg gttaagaatt
    27241 tagggctaag tttatcaata atagatgtag gatggccagc agcatcagct atagcttttg
    27301 catcaacagt aggggcttta attattccaa taggtcttgt ggtaaatata gttatgctaa
    27361 ttaccaatac tactcaaact gttgatgtag acatatggga ttactggcat tttgctttta
    27421 caggagcttt agtggcaggg gctactcaaa gtgtaatgtg gggagtattt gcagcagtag
    27481 caaatatggt aattgtattg gtaatggcag atttaactgc tccaggtata gaggaatatt
    27541 taggtatgcc aggtatatct cttcctcatg gatttacaca ggcatttgtt ccaattgcta
    27601 tagtagtaaa taaattatta gacttaatac caggcataaa taagattgag ataaatgctg
    27661 atacattgca gaaaaaattt ggattatttg gagaaccttt aataatgggg tctgtaatag
    27721 gtgtaataat tggtattgct gcgaaatatg atataaaagg aatattacaa ttaggtgtaa
    27781 ctatgggagc tgtattaata ttaattccaa agatggcagc attattaatg gaaggattat
    27841 taccagtatc agaagctgca caggaattta ttgagaagag atttaaaaac agaggcaaga
    27901 tttatatagg cttagattca gcagtaggaa taggtcatcc tgttacatta tcagttgcac
    27961 tagtgttggt tcctttgact atacttatag cagctatatt gccaggaaat aaagttttac
    28021 catttgcaga tttagcagta attccatttg cacttgtatt aatcgtacca attacaaagg
    28081 gaaatgtgtt tagaacatta ataataggaa taattataat tacttctgga ttattaatcg
    28141 caactaactt agctccatta tttacccaaa tggctttaaa tgctagtttt aaaatgcctg
    28201 aaggagcaac tatgatttca agtatttgtg atggtgcgaa tccattaagt tgggtatttg
    28261 taaaagttat gaactataaa gttattggag gagtagtttt tggagttata gctttaggaa
    28321 tggctattta caataggaat agaataataa atgaaaataa aaagctatct atagaagaat
    28381 aaggttaaaa caattttatt aaggagtgta taggttatga aaaaatataa atatgattct
    28441 aaaagatact tactcagtgt tacaatacca ggatttttta tgattttaat attgatttat
    28501 gcactgttta ataactatac aaattttaat ttgaatatat atagtttgtt aataattgtc
    28561 tgtacttatg gtatattcaa tacttttata tcatcaagta atcctaaaaa aattattatt
    28621 gatagcaaat gtatacattt tacctcattt atgactacac ataagtatga aattaaagat
    28681 atagaaaaga taagaataag agaattttat aataaaaaaa tttatctaaa aattaatgat
    28741 ggaaaacttt tcaaaggtag gtattggata agaacaaata tgtttaataa tagtatagca
    28801 ttatatagct atttcattga gttggaagag tgcttatatc cagattcact aaaatttaga
    28861 aataaaaaat ttgagaataa gaacatataa aaataaaaaa ttgaattgaa gcctagctta
    28921 atcttttttg ataagatata agtttgaact ttatactaaa tttttagaat tttcaatcaa
    28981 gacaataaca taatagctaa gcaattagaa cacaactaag atgtataagg catgtatatg
    29041 atgaatggga ggatttaatt aatgttatta gagaaattaa gaaaagaagt attacaagca
    29101 tctttagacc ttttaaacta taatttagtg acattaacag gaggaaatgt aagtgggaga
    29161 gatgaacaaa ctggctatat agcaatcacc ccaagtggaa tggattatag aaatcttaca
    29221 ccaagtgata ttgttatagt agatgtagat ggaaatatta tagatggaaa atggaaagca
    29281 tcagtggatt tatcagacca cttgtatata tataagcata gagaagacat aaatagtata
    29341 attcatacac attctacata ctcaagttgt tttgctattt taaatgaacc tatagaatgt
    29401 gcaagtacaa ctcttgcaaa tgaagtaggg ggttcagtac cagttgcaaa attttcgcca
    29461 ccaacatcta aaaagatggg aaaatgtgtt attgaagcaa ttggtgacaa aagagcatgt
    29521 cttttagcaa atcatggcgt aattgcagtt ggtccatctg taggacatgc tcttacagcc
    29581 gctgtaatgt tagaagattc agcaaaagta tattacttag caaaatcaat tggcacacca
    29641 gtgctactgc ctgatgaaga aattcaaaga gcgagagatg tattttttaa tgtctatggt
    29701 caggataaat aaattagata aaattttaaa agtaatatga aaatatagat attcaatgat
    29761 attaaggaga tttataatga tataataagt ttaatagtta agaagtaaaa tatgaaatgt
    29821 aatagtatat aaattcattt aagactaaaa agaataagat aaaataaaaa ggagtctgta
    29881 tttctatgta ttacttatta aacaaaagca caaatcctta ctttaatttg gcattagaag
    29941 aatatctatt tttaaatgat aaatataatg atgatattat aatcatatgg agaaatgaag
    30001 aatccatttt tataggtaaa aatcaaaatc catatcagga agtatatcat gatgttattg
    30061 aaaagggaga aattcctatt ttaagaagaa tatctggagg aggaactgtt tatcatgact
    30121 taggtaatat caatatgtca ttcatacaaa aagataggca acttcatgag atagattttt
    30181 tggagcatac taagtttatg caaaagatgc tttcaacctt aggactagat gtatctataa
    30241 ctgaaagaaa agatttattt ttaaatggga aaaaaatttc aggctctgca cagtctataa
    30301 aaagaaaaaa ttctctttat catggaactc ttctttacga ttcagattta aataaattaa
    30361 ctaaatattt aaattcaaat aaagcaactg aatcaaatgc aactaaatct gtttcaagta
    30421 aagttacaaa tattaagttt ttactcgaaa aagatataaa ttacttttta gattattgtg
    30481 ttgaatattt aaaatctaat ataaagaata taaaagaact tgaattggat gaagaagata
    30541 ttaaaagtgt atacaatata ggagaagata aatataaaaa gatagagtgg acatatggta
    30601 aaacgccgaa atttcaagta gtgctaccat ttaataatga aagtaaaata aatatacatg
    30661 ttaacagatg gaaagtatca aaatttttta tttcttatga tgataatgta attaatatgg
    30721 acaagttgtt agatttgaat ttctttaaag aagaaataaa agagagtatt ttagaaaatt
    30781 atccacatta catagattta atcaatttaa tattttaata taaaacctct aatttgataa
    30841 aattgtctta tatcaaacta gaggttttta atattcttgc atattaacaa ccattacaaa
    30901 attgtaaaat taaaaacaac actattgaaa aatcaatata tattgtaata aatatatgtg
    30961 tttttcatta gcaaatagac attaactatt tatacaactg aaaatttaat atataattaa
    31021 tcagatggtt aaaataaaaa tattaaaagt tttaataaat gatggttaaa aataaaatac
    31081 gaggtgatac catgtatagt gttataattg ttgcagcggg aagcggaagg agaatgaact
    31141 tagatataaa caaacagttc ataaaattaa gagaaaaaga aattattgct catacaattc
    31201 aagtttttta tgaaaatata aatatagatg aaatagtggt atgtataaaa aaagaagaag
    31261 aagatttttt taaagaaaat ataataaata agtataactt taaaaatata aaaatagcat
    31321 atggcggaaa agaaagacag gactcaatat ataatggttt aaaaaaatta gataaaaatt
    31381 gtgatatagt acttatccat gatggagcaa gaccatttgt cgaccataga ataatcaatg
    31441 aatctataaa ggtagctaaa gaaaaaaagg ctgtggttgt aggtgttcca gtaagtgata
    31501 ctataaagat agtgtcagat ggaacagtac aagaaactcc agaaagaaat ttgctgtggg
    31561 cagcacaaac ccctcaaacc tttgaatata atctcataat agatgcttat gaacaagcat
    31621 ataagaacaa ttattatggt actgatgatt caatgttggt agaaaatata ggtcaaagtg
    31681 tcactatggt aatgggttct tatgaaaaca taaaaataac tagtccagaa gatttaaata
    31741 tagcagaaca aatattaaat atggaaaaaa gagatgaagt taacagtaga aggagaatta
    31801 tatgagaata ggattaggat atgatgtaca caaattaaca gaggatagaa aacttataat
    31861 cggtggtgta gagataccac acgataaagg tttgttgggt cattctgatg ctgatgtatt
    31921 gatacatgca ataatggatt ctattttagg tgctctagca ttaggagata tagggaagca
    31981 tttcccagat acagatgaag aatataaggg agcagatagt atgaaattat tagaacatgt
    32041 gtataatcta ataacaagta aaggatataa aattggtaat atagacagta ctataattgc
    32101 tcaaagccct aagatggctc catatattga gagtatgaga agtaatatat caaaagtttt
    32161 aaacacagac attgataata taaacataaa ggcaacaaca gaagaaggtc ttggttttac
    32221 aggagcaaaa cagggaatag cttcacaaag tatttgttta ttattgttga caagtcagaa
    32281 taattaatat attattagta ataagtttaa tggatatcaa gtaataggcc tatatagaat
    32341 atctataatg tatgaattta agtgaaatta atataaatat aaaattagct atgataaaga
    32401 aatagtaaaa tgatgaaatc ttcacagaga gaaaacggtg gtgagagttt tcaagaggaa
    32461 gtctttgaac ctgtctttta gcttaaaggt ataaaaatct ttacggtagg aaccgttata
    32521 ttcccaaaag agagctattc atatagctaa ctagagtggt accgcggaaa ttaaaccttt
    32581 cgtctctata cttgtataga gatgagaggt tttttatatt ttcaggaagt taatattcag
    32641 gaggaatcta ttaatgaaaa tgtcaaaaat gtttatgccg acattaaaag aaatcccagc
    32701 agatgctgag attacaagcc atcaattaat ggttaggtca ggcatgataa aaaaaatgac
    32761 ttcaggtgtt tataaccaat taccaatggg gttaagagtg ttcaaaaaaa ttgaacaaat
    32821 aattagagaa gaattaaata aaaaagattg tcaagaaata ctttgtgcag ccttacttcc
    32881 ttctgaatta tggaaagagt ctggaaggtg gactgctatg ggtgaagaaa tgtttagact
    32941 aaaagacaga acagaaagag agtactgtct tgggccaaca catgaagaag cattcactga
    33001 tataataaga caagaaatta cttcatataa acaattgcca ctgaacttgt accaaataca
    33061 agtaaaatat agagacgaga gaagaccaag atttggtgtt atgagaacta agacttttac
    33121 aatgaaggat gcctatagtt ttgatgtaga tgataaaggt ttagataagt catatcaaga
    33181 tatgtttgat gcatatgtaa gtatatttaa tagatgtgga ttggagaata gccctgtaca
    33241 ggcagattca ggagctatag gaggttctac atcagccgaa tttatggtta agtcagaagt
    33301 tggtgaagat gaagttgtat tttgtagtgg atgtgattat gcagccaatg tagaaagagc
    33361 agaatcttgt aatctagcat cacaaaaaga agaaatgaaa gaattagaag aggttcatac
    33421 accaggagca gctacaataa aagagttaga agaattttta aaaacttctc cagataagtt
    33481 tgctaaaact ttagtatatg aggcagatgg aaaaacagtt gtagtcgttg taagaggaga
    33541 tagagaagtt aatgaaatca aagtatctaa tgccataggt tctgttatag aatttgctct
    33601 tgctacagat gatgtagtga gaaaagtaac taatgcagaa gtaggatttg caggtccaat
    33661 aggtataaat gctgactatg tatttataga taaagaaatt gttgaacaaa gaaacatagt
    33721 tgttggggct aataaaactg agtaccatat aaaaaatgct aactatggaa gagattttga
    33781 aggaatagtt ggagacttta gaaatgttca agaaggcgac aagtgtatag tatgtggtaa
    33841 gccacttgaa atagctagag gtgttgaagt aggacatata tttaaactag gaactaagta
    33901 ctcagaatct atgaatgcaa acttcataga caaagatgga aaatcaaagc ctatagtaat
    33961 gggatgttat ggaataggtg ttgaaagaac agcagcagct ataattgaac aacataatga
    34021 tgagaaaggt ataatatggc ctttgtcagt agctccatac catgttgtga tagttccagc
    34081 aaatatgaaa aatgaagaac aaatatcaat agctgaaaat atatataatg atttgcaagc
    34141 tatgggtgta gaagttttat tagatgacag agatgaaaga ataggtgtca aattcaatga
    34201 ttcagaatta ataggaatac ctatgaggat tacagtaggt aaaaatatta atgaaggtaa
    34261 agtagaattt aaacttagac ataaagaaga taaagagata attgacatag aagaaataaa
    34321 tgaaaaagta aaggcagagt ttatcaggaa taatgttagg ttaggataat aacttaaata
    34381 agatattgta tagataatca aagttgtact ttatagacac cattttatct atatataagg
    34441 atataaaatg gtgttttttt ataaaacaaa taaatgagga ggtaattaaa atggcaaaaa
    34501 atgaaaaaca atttgttgaa gaaataacaa agatggaaga tgattttcca caatggtaca
    34561 cagatgtaat aactaagact gacttagttg attatgcccc agtaaaaggt tttatggttg
    34621 taaagccata tggatatgca ttatgggaaa agatgcaaga atttatggat aaaaaattta
    34681 aagaaactgg acataaaaac tgttattttc cattattaat accagagagt ttattaaaca
    34741 aagaagcaga acacgttgaa ggttttgctc cagaagttgc atgggtaaca catggaggaa
    34801 ataaaaaatt agaagaaaga ttatgtgtaa gacctacttc agagactata atatgtacaa
    34861 tgtatgcgaa atggttaaaa tcatatagag aattaccata tctttataat caatggtgct
    34921 cagttgttag atgggaaaaa tcaactagac ctttcttaag aacatctgag tttttatggc
    34981 aagaaggtca tacgttacat gaaacagcag aagaagcaca agaagaaaca atacaacaat
    35041 tagaagtata taaagcgcta tgtgaagaat tacttgcaat gccagttgta gctggtcaaa
    35101 aaagtgaaag tgagaaattt gcaggtggtg aaagaacata tactatagaa gctatgatgc
    35161 atgatggtaa agcattacaa tcaggtacaa gtcacttcct aggtcaacac tttactaagg
    35221 cttttgatat tacttttgca gatagggaag gaaatttagc taatccatac catacatctt
    35281 ggggagcatc tacaagactt ataggtggac ttataatgac tcatagtgat aacagaggtt
    35341 tagtattacc accaagagta gctccaattc aagttgttat agttcctata gctgctaaaa
    35401 aaggaaatgt aatggagact gttgataaaa tatatgctga tttaaaagct aagggagtag
    35461 ctgtagaagt tgatgataga gataactata caactggatg gaaatttaat gagtgggaaa
    35521 tgaaaggtgt tccagtaaga gttgaaattg gaccaaaaga tatagaaaat aatcaagcta
    35581 tggtatttag aagagatact ttagaaaagg attctatgcc tttagaagga ttagctgatg
    35641 ctatatgtga tttatttgat gttatacaca atgatatgtt tgaaaaagca agaaaacata
    35701 gagaagacaa tacatctata gttgaaaata tggatgagtt tagaaaagct ttagaagaaa
    35761 agccaggatt cataaagact atgtggtgtg gagatgcaga atgtgaagct aagattaagg
    35821 aagaaacagg agcaactata agatgcttac cttttgaaca agaaaactta ggtcacaagt
    35881 gtgtgtactg tggaaaagaa gcagatagta tggtagtaat ggcaaaagct tactaaaata
    35941 catttaaata aaaactgggg tagaaagtat ttaatacttt atcccagttt tttgtttttt
    36001 atgagtaata aaatgtattt gtaactatgt cataagataa gtcatagata cttatattaa
    36061 aaagaatata atagagaact atttttaata attacatatt aatgaaagca aaatattttg
    36121 ttatatagat tttcaataaa gcaaacaata aatataaatg aatattaata aggagtgctt
    36181 ttaattttta gaaaataaat gacttaaaag aaagatttat gaaattaaaa ctaggatttt
    36241 ctgatataat aaacatgtgt atttttaaat aaaaaggata ttattattag atttgattaa
    36301 aaataaactt gcaaaacaat gtactagttt aatattatag ttatattgaa taaaatatca
    36361 ggaggaagta aaaatgaatg taagagtaag gtttgcacca agtccaacag gatttgtaca
    36421 tataggtagt ttgagaactg ctttatataa ctatttattt gcaaaaaaaa tgggcggaga
    36481 atatatatta agagtggaag atacagacca aagtagatta gtagaaggtg ctatagagaa
    36541 tatgcttaat gctatgaaat gggctggggt caaccatagt gaaggtgtta tattagatga
    36601 tagtggaaaa gtagtacaaa aaggagaata tggtccatat attcaatctc aaagattaga
    36661 tatataccaa gaatatataa agcaactttt agatagtgga aaagcttatt actgtttctg
    36721 tacaaaagaa agactggatg aagtaagaga tgctcaaaga gcagcaggag aaacagctaa
    36781 atatgatggt cattgtaaga atctttctaa agaagaagta gaagcgaata taaaagcagg
    36841 aataccatat gttataagat taagattgcc agagaatcat acaattaagt ttacagactt
    36901 agttagagga gatatggaat ttaatactaa tgacttagat gaccaagtat taatgaaaac
    36961 agatggattt ccaacttatc attttgcagt agttgttgat gactatttga tgaaaattac
    37021 acatgttata agaggagaag aatgggtatc atctactcca aaacatgttt atttatatga
    37081 agcttttgga tgggaagcac ctgtatttgt gcatttacca aatatactta ataaagaaaa
    37141 gaaaaaatta agtaaaagac aaggtgatgt agctgttgaa gactttaaga aaaaaggata
    37201 tttaccagag ggattagtaa actatgtagc attagttggt tggtctcctg aagataatca
    37261 agaattgttt acaatggagg aattagaaaa agccttctct gtagaaagag tatctaaaag
    37321 tggtggagta tttgatactg aaaaattaaa ttgggttaat cagcactata taaaagatgg
    37381 tgatgatgct tatctaacag acttagcaat accattttta atagaagatg gatttataac
    37441 agaagaagaa gctactaata aatatgattt cttaaagagt atgatatcag tacttaaaga
    37501 gaaattacaa tatgtaaaag aagttactga acatgcaagt atattttttg gagataaaat
    37561 agaggtagaa actgaagagg gaagagagtt cttaagatta gaacatatac ctactttaat
    37621 agatgctttg agagaaaaaa tagaaaaaac agaggtatta aatgctgagt ttgttcaagc
    37681 tatgcttaaa gaaatacaaa aagagtacaa aataaaaggg aaaaatttat ttatgggctc
    37741 aagaataatt ttgacagggc aaatgcatgg tccagattta ccaaaagtaa tggaagtttt
    37801 aggaaaagaa acttgcttaa atagaatagc ttatgtaaaa aataatatat tatagtcata
    37861 aaagtccgct aatttagaag cggacttttt ttgtgttagt atttggtgaa aatatctgct
    37921 taagaaaatg aaggtattta aggtaataaa tttaatatat aaaaagcaaa gcaaaaatat
    37981 aaataaaata tgaataataa actaataaaa tattaagcat agaagaaggg aatctattat
    38041 tttagtttga tttaattatt aagggggtaa ttactatgta tagtaatatt gatgatgtta
    38101 aaaaggaatt aaaggagcta tgcttagaat atgttacaat tttagaaaaa ttaaaagatg
    38161 aaaaaatgat tacagaagaa acttttgaaa agtgctcttc tcaaaaaaaa atatttttag
    38221 aagaacaata gaggatggta atagtattat tattatgtag tttgaaagat agtacgaaaa
    38281 atgatagtaa tactattatt tattgcaatt ttcaactata atataatata taatgttaag
    38341 aagataattt ataaaaatac agtgaggtga tgagtgtgaa agtttataat acattgacta
    38401 gaacaaaaga agaatttgtt ccattagaag aaggaaaggt aaaaatgtat gtgtgtggtc
    38461 caacagttta taactatata cacataggta atgcaagacc atttataata tttgatactc
    38521 taagaaggta tttagagtat agaggatatg atgtaactta tgtacaaaac tttacagatg
    38581 ttgatgataa gattataaat agaagtcatg aggagggaat atctcctgaa gaagttgcgg
    38641 ctaagtatat aaaagaatat tttgtagact gtgatgggct aggaataaaa agagctactg
    38701 ttcatcctca ggttacagat aatatacaac agattataga gtttataaaa gagttggaag
    38761 ataagggata tgcatatgca gtaaatggtg atgtatattt tgatacaaat aagtttgaag
    38821 gttatggaaa actttcaggt caaaaacaag aagatttaga ggcaggggct agaattgagg
    38881 ttaatgacca aaaaagacat cctatggact ttgttctttg gaaggcaaaa aaagaaggtg
    38941 agccaggatg ggatagccct tggggagaag gtagaccagg atggcatata gaatgttctg
    39001 ttatgtctaa gagatattta ggtgaaacaa ttgatataca tgcaggtggg caagatttaa
    39061 cattcccaca tcatgaaaat gaaatagctc aaagtgaagc tagaagtgga aaaacattct
    39121 caaaatactg gatgcataat ggatatataa atataaatga tgaaaagatg agtaaatcaa
    39181 aaggtaattt ctttacagta agagatatat caaaattata tgatttagag atagtaagat
    39241 ttttcatgtt atcagcacat tatagaaatc cagtaaactt tagtgatgag atgttaaatc
    39301 aagctaaagc aggtcttgaa agactatata atactaaaga aaaattagaa tttacgctaa
    39361 gtaatttagt agaatctcct ttaacagaaa aagaagtaga gcttgttaaa gaattagatg
    39421 actttagaca aaaattcata gatgctatgg atgatgatgt taatacagca gacgcagtaa
    39481 gtgtaatatt tgaattagct aagttaataa attctaatgt agatgaaaat tcttctttgg
    39541 agtttgctaa aaaatgctta gatgaattta atgaacttac aggagtatta aatattgtaa
    39601 ataagaaaaa ggatactgta ttagataaag acattgaaga attgatacaa aaaagaactg
    39661 atgcaaagaa aaataaagag tttcaattag ctgatgatat tagacaacaa ttactagata
    39721 tgggaattgt attagaagac acaagacaag gtgttaagtg gaaaaggata taaaaatgga
    39781 aaaaactgaa ttagttacta tgtcaccatt agttttagca tacttaggtg atacagtgta
    39841 tgagacatat ataagagaat atttaattag acagaataca caaagaaaag ttaatgattt
    39901 gcataaacta gctataaagt atgtaaaagc taaagctcag gcaactataa ttcatgaagt
    39961 tgaaattgag ttaactgaag aagagagtaa aatttataaa aggggaagaa atcaaaagtc
    40021 aaatacttct cctaagaatg cagatattat agactacaaa catgcaactg ggtttgaggc
    40081 attagttgga tatttgtatt taaataatga aatagagaga cttcaatata ttatcaataa
    40141 aggaatcaaa attattgaaa gagatatgta aatattaaag agtgttgtct taataataag
    40201 taataaggca acactttttt tataactaat gtataataaa tatatagaaa ttagtaatga
    40261 gaaaggataa aaagttatga aagtaaaatt aatatcacat acacctgaac cagaaaaagt
    40321 aatagctatg gcagctaagc tatgttattc accagttggg acagacgaaa tagaaaaaga
    40381 cttaacagat gaaagtatag agaaattttt aaatatgtta ttaagtatag gtcatgggtc
    40441 aatattagaa catgcttcat ttacattttc aatagaaggt atttcaaggg catgttcaca
    40501 tcaaattgtt agacatcgta tagctagttt ttcacaacaa agtcaaagat atgttaaatt
    40561 agaacaattt gagtacataa ttcctccaga aatagaaaaa atagaaaagg caaaagagtt
    40621 atttatagac tccatgaaaa aagaccaaga gaattatgat aagttagttg aaatattgtt
    40681 tgaaaatcat tataatgacc taataaaaaa cggtaaaaat gagaaaacag ctaaaagaca
    40741 agctgagaag aaagcaatag aagatgctag atacgtattt ccaaatgcat gtgaaacaaa
    40801 gatggtattt actataaatg ctagaagttt gtttaatttc tttgaacata gatgctgtga
    40861 aagagcacag tgggaaataa gaaatttagc tgtggagatg ttaagagagg ttaaaaaggt
    40921 tgctcctata ttatttaaaa agactggtcc aagttgtgta aatggaagtt gtccagaagg
    40981 aactatgact tgtggagata tagttcaagt tagagaaaaa tttaaggcct tgtaggaggt
    41041 gaataatttg gcgagtatag aaggaagaaa tccggtaata gaagcaataa aaagcgacag
    41101 agaaatagat aaaatattaa ttgcaaattc agctaaagaa ggttcaatta agaaaataat
    41161 aggaatggct aaagataaga atataattat tcagtatgtt gataaacata agttagatga
    41221 agtaagtaca agtcattcac atcaaggtgt aatagcttat gcaagtgagt ataagtatta
    41281 tgaattagat gagctaatag atttagcaaa gaataaagat gaagacccat ttttcattat
    41341 attagatgag ataacagacc cacataattt gggttcaata ataaggacag cagatgcagt
    41401 aggagcacat ggagttatca ttccaaaaag aaggtctgta cacataactc ctgtagttgc
    41461 caaagcatct gctggagcag tagaatatat gccagtttgc aaggtaacca atatagttaa
    41521 tacaataaaa agactcaaag aagaagggct gtggattgct gcagctgata tggatggaga
    41581 aactttttat aaacaaaatc ttactggtcc tcttggtgta gtaattggaa gtgaaggttt
    41641 tggaatatct agattggtta aacaaaactg tgactttata gtaaaaatgc caatgatagg
    41701 taatgttaca tctttaaatg catctgtagc aggtggaata cttttatatg agatattcag
    41761 acaaagactg gataaaagta aataggcatg aaaaaaaata taaatcatta cttaataata
    41821 gatggctaca atattataaa tgcgtgggac aatttgaaag aactggctaa agaggactta
    41881 gaagattctc gagaaaagct tattgatgac attatagaat tttctgagtt tatgggttat
    41941 aagactataa tagtttttga tgcttataat gttaaaaatt ctcgagaaaa agttgaaaaa
    42001 agaaaacaca taacaatagt ttatacaaga gaacaccaaa cagcagatag ttatatagag
    42061 aaatttataa cttctttatc aaagtatgat gatgtaaaag tagccactaa tgactatgca
    42121 gaacagcaaa tgattttagg aaaaggtgct actagaatgt ctgcaagaga attaaagtta
    42181 gagttagatc gttccaagaa taaaatgaag gaaaaaaata tcggtttgag gaaaaaaatt
    42241 cagcgaaatt ggttggagga aaggttagat aaagaaacat tgtcgaaact tgagaacatt
    42301 cgtagaaagc gttgaaatta ctaggttctt tagactataa tatacctata aatttgtttt
    42361 atatatgggg gagatttaca tgttggtagc aaaagaaaaa agttatgagt tagtggacaa
    42421 ttgtcagcag gatgagtata acattgtatt aagagcaagt gaaggggata aaatagcact
    42481 agagtacatt attactaaat acagaaattt tgtaaaggca aaagcaaagt catatttttt
    42541 aattggagca gataaagaag atataataca agaaggaatg ataggccttt ataaggcagt
    42601 tagagatttt gatggaagta agaccaattc atttaaatgt tttgcggaga tatgtataac
    42661 aagacaaata ataactgcta taaaaactgc aacaagacaa aaacatatac ctttaaattc
    42721 atatgtttct ttgaataaac caatatatga tgaagagtca gacagaacac ttttagatat
    42781 tatagctaca agtatagtaa cagatccaga agagcttata attagtaaag aagagttaaa
    42841 aaatatagaa tcaaaaatga acgaattgtt aagtgacttg gaattagaag tactagaatt
    42901 atatttaaat ggaaagtcat accagtttat agcggacaag cttaaaagag atgtaaagtc
    42961 aatagataac gctttacaaa gggttaagag aaaattagaa aaacatcttg aaaacagaaa
    43021 tgattaatag taaaatactt accataagct tattgtgagc aaaattaatt tatatcgaaa
    43081 gataagggag gaaattcaaa atggctaaag ctaaatacga aagaacaaaa cctcatgtta
    43141 atatagggac aataggacac gtagaccacg gtaaaactac attaacagca gcaataacaa
    43201 aaacattata tgacagatat caattaggag aagcagtaga tttcgcaaac atagataaag
    43261 ctccagaaga aagagaaaga ggaatcacaa tatcaacagc acacgttgag tatgaaacac
    43321 caaatagaca ctatgcacac gttgactgcc caggacatgc tgactacgtt aagaacatga
    43381 taacaggagc agcacaaatg gacggagcaa tattagtttg ttcagcaaca gatggaccaa
    43441 tgccacaaac aagagagcat atactattat caagacaagt tggagtacca tatatagtag
    43501 tattcttaaa caaatgtgac atggtagatg atgaagagtt attagagtta gtagagatgg
    43561 aagtaagaga tttattaaca gaatatgatt tcccaggaga tgacactcca atagtaagag
    43621 gttcagcatt aat
//
LOCUS       DAEHWM010000027        43047 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.028, whole genome shotgun sequence.
ACCESSION   DAEHWM010000027 DAEHWM010000000
VERSION     DAEHWM010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 43047)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43047)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43047
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.028"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            113..1402
                     /locus_tag="KNP36_001507"
     CDS             113..1402
                     /locus_tag="KNP36_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HBF0873388.1"
                     /translation="MRELLKVTLIVMLVLINAFFVACEFAMVKLRSSRIDTMITEGNN
                     NAKRCKIIKDNLNSYLSACQLGITLCSLALGWMGESTVKELILPIVSVFNLSESIIYT
                     ISISISFLIITMMEVVIGELVPKALALYNTEKIMLSTSFLLVGFYKLTYPIIYFFNLS
                     TDLFLKPFGYSQADEVDEPHTGDEIRLLVEESYKSGLIDESEQRLVDNIFEFEEKKIR
                     EIMVPRTDMVCIYESDSEEKILAILKEEGVTRYPVCRKNKDDILGFVHIRDLYNQKIN
                     ENKIELEEILRDIIYISENLTIDKALERIRKEKLQLAIVVDEYGGTSGVVTIEDILEE
                     IVGEIQDEFDKEETHIKKIGAGSYLVDGTESINYINKYFGLDIEHDGFDSIGGWISYM
                     LGSNIKVNQSVTFENYNFTILELDKLRVVKLIIKSVI"
     gene            1431..2111
                     /locus_tag="KNP36_001508"
     CDS             1431..2111
                     /locus_tag="KNP36_001508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family phosphatase"
                     /protein_id="HBF0873389.1"
                     /translation="MQKVEGIIFDMDGVLFDSERISLEFWMETFEKYGYTMTKEIYTS
                     VMGRNRKGIIEGLTDIYDSSVPIIDLYDEKTKNMIEFMERKGAPIKLGVNELISFLKE
                     NGYKMAVATSTKRERAVKRLAKANLKDYFDAIVCGDDVVNSKPNPEIFLKAAKKINVN
                     PQNCIVIEDSPMGVEAAYNGGIRCINVPDLKEPDEQIKSQSHKILENLLEVREYLKSL
                     NSKECHNL"
     gene            2212..2751
                     /locus_tag="KNP36_001509"
     CDS             2212..2751
                     /locus_tag="KNP36_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative ABC transporter permease"
                     /protein_id="HBF0873390.1"
                     /translation="MDNVGSLLYFLFNFFLYGFIGWIIENLYSYYKQGHFQEDGFLNG
                     PFKPMYAIAMSIIIEVSRFIDPNNIFALLLLCLVVPTVVEYITGILMKVYFNKVYWDY
                     SDYKYNSRGIVCLKFSVYWTILTFIGVRYFQVYIVDSLYSLIIPYWPIVVTILLVTLF
                     VDEILTIKFLRGNKDIVER"
     gene            2927..3946
                     /locus_tag="KNP36_001510"
     CDS             2927..3946
                     /locus_tag="KNP36_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBF0873391.1"
                     /translation="MMGKIRFGIVGTSNIANIFLRAASRVKDFELVAVYSRNLEKARE
                     FGTLYGASIFFDDLEQMAKSKDIDAVYIASPNALHSKQTITCLKHKKHVLCEKSLASN
                     LKEVKSMIKTAKDNNVLLMEAMRITCVPNFKAVKENLYKIGKIRRFFGSYCQYSSRYD
                     KYKNGIIENAFKKELSNGALMDIGVYCIHPMVNLFGAPKTVKAVSHILQTGVDGEGSA
                     VFQYDDMDAIIQYSKVADSYIPSEIQGEEGSIIIEKLNLFEKAIIKYRDGREEDISIP
                     KEKAEEKPREIEGMYYELVEFISLINNNKIESNINSHENSIIVMEIMDEIRRQSSIVY
                     PADSI"
     gene            4234..5424
                     /gene="dltD"
                     /locus_tag="KNP36_001511"
     CDS             4234..5424
                     /gene="dltD"
                     /locus_tag="KNP36_001511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HBF0873392.1"
                     /translation="MRKLIYFITPFIIGVVFLFGLDKFLDSKTDELLREKNLLPIMDD
                     TLSDIKDKGVTANNHFLREKDIMILGSSELSNSTKQHPKYYFNTNRSKNKVFAIGRAY
                     TQTLQDAAILGSMNPNIDNKKVVLLISMQWFMEKDGVTSHHYQSRFSPIQFYRFLDNP
                     KISKQNKIEYAKKSSKLLWGSDEYKAEALYAKLYEPKTFPEKAEKVLLEPYFQGRKYC
                     IALKEKGILYKRLIKLDKKRATKRKRPINWSYERKKAIEDAKKRVGKNPLNIDKYYYK
                     EHFKDGIEQYKGRDKDVNLLTSKEFENYKLMLNVCTDLGIKPVVVLIPSMDKFYNLTG
                     ISEKERNQYYDKAQKIAESKGFEVLNLKDKGSDKYYLRDVMHLGTKGWVDVCERLFKI
                     FKEQ"
     gene            5545..7059
                     /locus_tag="KNP36_001512"
     CDS             5545..7059
                     /locus_tag="KNP36_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase"
                     /protein_id="HBF0873393.1"
                     /translation="MKIIEGIKKYSNTDRTALMCNGDKLSYKDLNEYSDAISVFLKDV
                     YKEEDTPIVIYGNKENMIMACMIGALKSGRAYVPLDISFPIDRVFEVTKEIKPKVLFN
                     FSDEKDFGDINVIDMDKLNYIINEYQGKSLDKENWVKDDENAYILFTSGSTGKPKGVQ
                     ISSNNLDSFSDWISPYLNIDGSEKVIMNQPAYSFDLSVTTIYPGLIHGATLFSISKDV
                     LADYKELFRQFSISDIAVWVSTPSFAGVCITEKEFNSKMLPNLESMIFIGEALSKNLT
                     KELMSRFPNTRIINGYGPTEATVGVSVNDMTQKAIDDEKSLPVGYPMSNCKIKILDED
                     GNELKENEKGEIIIIGPSVSKGYFNNKEKTDEVFFYDEIDGVKWRAYKTGDMGYLLDG
                     NIYYCGRKDFQIKLNGFRIEIEDIENNLRKVHNVKNAVVLPVYKDEKIAYLKGIVELN
                     EKNDLSNIKNGMIIKKELGKYIPSYMIPRNISIISEFPTNINGKIDRKKLMEEI"
     gene            7059..8207
                     /gene="dltB"
                     /locus_tag="KNP36_001513"
     CDS             7059..8207
                     /gene="dltB"
                     /locus_tag="KNP36_001513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HBF0873394.1"
                     /translation="MIFSQYGDYFYLYILLLTSIPAVILGLMGKNIKYYGMLASLFMI
                     FLIVGIDVQLKYLVIFIILEVIIVKGYEYVRRKTKNKYIYWGFLFASMLPIIINKISP
                     VTSFGIIGFIGISYLNFRTIQMVIEIYDGAIKEVKISKMLYFMLFFPTLSSGPIDRSR
                     RFEQDLEKQISRKEYIEEYLLPGIKNIVMGVGYKFVIAFLINTYWVSRIPKDMSFINI
                     LSYMYAYSLYLFFDFAGYSLFAIGTGYIFGIQVPINFDKPFISKDMKEFWTRWHISLS
                     RWFGDYIFSRFVMSSMRKKRFKKRTTAAHVAQMITMITMGFWHGLTWYYVAYGVYQGL
                     ALVLTDIYQRKSKFYKKHKKDKWFERVQIFITFHIVCFGLLIFSGYLA"
     gene            8226..8456
                     /gene="dltC"
                     /locus_tag="KNP36_001514"
     CDS             8226..8456
                     /gene="dltC"
                     /locus_tag="KNP36_001514"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HBF0873395.1"
                     /translation="MQETVIEIFEDVLGTDEIREDLDLNLFETELLDSLAIIEVLLEI
                     ENRLGIELQPTDLERKDMSTVNNLVKFLETRK"
     gene            8673..9458
                     /locus_tag="KNP36_001515"
     CDS             8673..9458
                     /locus_tag="KNP36_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBF0873396.1"
                     /translation="MSLNSIDRKKEILKLLDSKGKVNTKELVKRLEVSSETIRRYLEE
                     LENENKLKKVYGGAIKINYGVIEPEHIKRNNTNLDKKQSIAKYAAKFVNDNESIIIDE
                     GTTNLQIVDYIISVNNLKIITNSYPVLSKLISYENQGLFDGEVIFIGGKVNLKHQRTA
                     CPMSIDTMKNLYVDKAFISSEGILDSFGISSIDQNKALLSKEYIKNSKESFVLCDSSK
                     IGIASMYKIADLEELDFVICDVEPPNEWKDKLNEINITWIEAK"
     gene            9737..11647
                     /gene="phnW"
                     /locus_tag="KNP36_001516"
     CDS             9737..11647
                     /gene="phnW"
                     /locus_tag="KNP36_001516"
                     /EC_number="2.6.1.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-aminoethylphosphonate--pyruvate transaminase"
                     /protein_id="HBF0873397.1"
                     /translation="MKKIYGEKIKAVVFDWAGTTVDYGCFAPLNVFIEIFKRRGIDVT
                     MEEARKPMGKLKIDHIREMCEMDRIKNIWSDKFGKVPTEDDVNELYAEFEPMLFETLE
                     EYTTPIPHVVETIEKLRKNGLKIGSTTGYTREMMNIVEPNAAKKGYSPDFLVTPSEVS
                     QGRPYPWMCYKNAEALGVSPMSSMVKVGDTISDVKEGVNAGMWSVAVIKGSSELGLTQ
                     EEVENMDKEELKAKMSIVSKKFKEAGAHFVIETMAELEDILIKIENETIKSDFVPEND
                     YILLTPGPLSTTKSVRASMLKDWCTWDVEYNNLVQDVRRRLVSLATQNTDKYTSVLMQ
                     GSGTFSVEAIIGSTISKDGKLLVIANGAYGKRMKDICNYLNIQFVDCTFKDIEAVDLN
                     VVENLLKENKDITHISMVHCETTTGRLNPIQEVGKLAKEYNKIYIVDAMSSFGGIEID
                     VEDFNIDFLVSSSNKCIQGVPGFGFIIANKEKLSKCKGIAKSLSLDVYAQWETMEKNN
                     GKWRFTSPTHVVRAFYQALLELEEEGSVEKRYARYKENQFTIASRLKSLGFDTLVNDN
                     AQSPVITTFLYPKNAKFEFMEFYTYLKDNGFVIYPGKLTDIDTFRIGSIGEVYPTDME
                     RLADVIEKFINR"
     gene            12006..12554
                     /locus_tag="KNP36_001517"
                     /pseudo
     CDS             12006..12554
                     /locus_tag="KNP36_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426706.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            12656..12865
                     /locus_tag="KNP36_001518"
                     /pseudo
     CDS             12656..12865
                     /locus_tag="KNP36_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861712.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4004 family protein"
     gene            13434..13841
                     /gene="tnpA"
                     /locus_tag="KNP36_001519"
     CDS             13434..13841
                     /gene="tnpA"
                     /locus_tag="KNP36_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013824389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="HBF0873398.1"
                     /translation="MEVTHGRGYVYLVQYHIVWCVKYRHPVLTNEIEEDLINILNKIA
                     EDNKFQILECNSDKDHIHLLINCSPQHYIPDIIKALKGVSARLLMKKHGEQLKKKLWG
                     GHLWNPSYFVATVSENTEEQIRKYINNQKKQVK"
     gene            13843..14961
                     /locus_tag="KNP36_001520"
     CDS             13843..14961
                     /locus_tag="KNP36_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0873399.1"
                     /translation="MAVVEKAYKFRMYPNKKQQELINKTFGCCRFVYNKYLAKRIEVY
                     KNNKETFTYKQCSSDLTNLKKELKWLKEPDKFSLQNALKDLDNAYKKFFKEKAGFPKF
                     KSKKINRFSYKTNFTNGNIMYCGQYIKLPKLGMVKVRDKQVPQGRILNATISKEPSGR
                     YYVSLCCTNVDIEVFENTNNQIGLDLGIKEFCISSCGDFIENPKYLKKSLNKLAKLQR
                     ELSRKTIGSLNRNKARLKVARLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNM
                     IRNRKLSRLISDVSWSEFVRQLKYKANWHGRQIVKVGKFFASSQICNKCGYKNEEMKD
                     LNIREWICPSCNETHDRDINASINILKEGLRLITIQNK"
     gene            15079..15489
                     /locus_tag="KNP36_001521"
                     /pseudo
     CDS             15079..15489
                     /locus_tag="KNP36_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861712.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4004 family protein"
     gene            complement(15789..16376)
                     /locus_tag="KNP36_001522"
     CDS             complement(15789..16376)
                     /locus_tag="KNP36_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rubrerythrin family protein"
                     /protein_id="HBF0873400.1"
                     /translation="MNLKDSKTKENLLRAFAGESQARNRYNISASVAKKEGLYIIESL
                     FNYTADQEKSHAKQFFSKLKEFAGENISISGAYPVDLYDKTAQHLKAAQHNELQEWDD
                     VYKNFGKTAREEGFESIAKLFENIAEIEKVHGDRFGRYATDLEEGTLFRRNEDIQWIC
                     THCGHIHIGKEAPKACPVCLHPQGYFLDFKNSLFE"
     gene            complement(16462..16899)
                     /locus_tag="KNP36_001523"
     CDS             complement(16462..16899)
                     /locus_tag="KNP36_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0873401.1"
                     /translation="MEDKYIVHFISKTKASMIKFIENKLSKNGLGELIPTHGNILTAL
                     YENNGILTMKEIAAKIGKDKSTVTVLVNKLINLGYLERQKCTNDKRITYIKLTKKALL
                     IEDTFNSISTQVKETAYHNITENEKQEFLRILKKINDNFKNAD"
     gene            17003..18001
                     /locus_tag="KNP36_001524"
     CDS             17003..18001
                     /locus_tag="KNP36_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhdH/YhfP family quinone oxidoreductase"
                     /protein_id="HBF0873402.1"
                     /translation="MNKKFKSLYITEEEGNFRRNIVEREVDTLPEGEVLIKVKYSSLN
                     YKDALSANGNKGVTRKYPHTPGIDASGIVESSSCDDFKIGEEVLVTGYDLGMNTSGGF
                     SEYIRVPSSWVVKLPKNLSLKEAMDYGTAGFTAALSVYKFIDSVDKNMGDVLVTGGTG
                     GVAVIATKILIKLGYSVVVSTGKLEEQKEVLLNLGVKDVIHRSEVDDNSGRPLLRPRW
                     AGVIDTVGGNTLATAIKTTNYCGAVTTCGNAGGVDFTSSVYPFILKGITLYGIDSVDC
                     PMNLRLKIWDLLSNEWKLDDLDDMVNVVSLEELNDSIDSIMAGKHVGRTVVDLEKI"
     gene            complement(18121..19047)
                     /locus_tag="KNP36_001525"
     CDS             complement(18121..19047)
                     /locus_tag="KNP36_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="HBF0873403.1"
                     /translation="MSKENKNVRIAVVQASPVIMDLEKTVEKALGLIKEAGRKGANIV
                     VFPEAFIPAYPRGLSFGFVVGSRTMEGREDWKRYYDNSVPVPSATTDLLGKAAQEAGV
                     YLSMGITERDGNDINCTLYCTNLFFSPEGKLIGKHRKLKPTGTERCIWGEGDGSTLTV
                     VDTPYGKMGSLICWENYMPLARTALYAKGVKLYIAPTADSREEWQATMKHIALEGRCF
                     VIGCNQYVEKNMYPTDLNYYKELDAEPEIMCPGGSCIVDPFGKYVAGPIFNKEEMLIA
                     DLDLEKIVLSRLDFDSEGHYSRPDVFELIVHE"
     gene            19432..21036
                     /locus_tag="KNP36_001526"
     CDS             19432..21036
                     /locus_tag="KNP36_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0873404.1"
                     /translation="MKEKIYYNGNIITMEDSICGDAILIKDKIIKKIGTKEEVFALKN
                     KDTEIIDLQGKTLMPSFIDSHSHLIAFATTLKLVPLEDATSFKDIVKKIQDFKESNNI
                     KKGDWIIGFSYDNNFLEENKHPDKSVLDSASSENPILISHASGHMGVANTLGLKQLGV
                     TNETRDPEGGHIGRVEGSEEPNGYLEENAFFNVASKIKQPSSNEIFNSIEKAQNIYLS
                     YGITTAQEGLMEENQFNILKAMANQNKLKMDVVGYVNLKKSKSVADNNREFIKKYINR
                     FKIGGYKIFLDGSPQGKTAWLSRPYENSDDGYCGYPIYKDEEVEKFIDISLKEKMQLL
                     THCNGDAAADQLIDAFEKVLNLKEQSSENHIRPVMIHAQTVREDQIDDMKVINMIPSY
                     FVAHTYYWGDIHIKNLGEDRAFKISPLKTTIEKGLIYTLHQDTPVIAPNMLETVWCAV
                     NRITKKGIQIGENEKISPLDALKGVTINAAYQYFEEDKKGSIKEGKLANLIILDENPL
                     TIDPMKIKDIKVLQTIREGEVLYSLK"
     gene            21852..23123
                     /gene="serS"
                     /locus_tag="KNP36_001527"
     CDS             21852..23123
                     /gene="serS"
                     /locus_tag="KNP36_001527"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HBF0873405.1"
                     /translation="MLDIKRIRENLDCIKKAMERRGEKDFNLDEVVKLDDERRKILQE
                     VEVMKNELNTASKNIPNLIKEGKDVENEKIKLKELSDKIKVIDQNLKEVEDKMEYLLM
                     RIPNVPHPEVPQGETDEDNVEVRTWGKTTTFDFESKAHWEIGTELGILDFETASKITG
                     SRFTLYKGLGARLERALLNFYLDTNTKVNGYTEVIPPFMANRNSFLGTGQLPKFEEDM
                     FKIEGMDYFMIPTSEVPLTNIHANEILKFEQLPINYTAYTPCFRSEAGSAGRDTRGLV
                     RQHQFNKVEMVKIVAPEESYNELEKLTNNAETMLQLLNLPYRVVKICTGDLGFTASFK
                     YDVEVWMPSYNRYVEISSCSNCEDFQARRAGIRFKRDKDSKAEYVHTLNGSGLAIGRS
                     VAAILENYQQEDGSVVVPEVLRPYMGVSVIK"
     gene            23401..24906
                     /locus_tag="KNP36_001528"
     CDS             23401..24906
                     /locus_tag="KNP36_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBF0873406.1"
                     /translation="MKIQNTEWGYIEWKHTYDENNPKQAMNIYIAVTMPGKKHFNHVH
                     YGQEQMIYILEGEGLYIINGVWKPFYQGMIFYIESGSTHETINTGDREIKELIVSNNV
                     DDVGESEVIDINPNNYLKKTLINYSESTLNLYAAVESIRGQFIDPFKIPLIIYDDSWN
                     IVLKNPYFPLFCFEKCNPMKFPQNCDCMNQKSSNQFVCEYGITIYNIPILYKSNSIGV
                     IRGGYVLLSDLNLDTEHNNLYDIPEGAARSIKRLLKQISKNIINFCSFNDIRKDLQEK
                     EKTIARTYHYGEQLEMNLKVAQDMVTNLRINHHFLFNTLNSMASIALDDGSYDLYSAI
                     IDLSRMFRYTMRSDLRFVELESEILYIKNYLNLQKLRYGDALKVKYLIPEKLYNLSVP
                     FNFIQPIVENAFTHGFRDIDTEKRIEIIARLDSQYAIIEIHNNGTILDGNNIDKIKAG
                     IRSNNGHGLSLIYTKFTSAYGNNFDMDIKSSDNEGTYIMIKIPIENYKEYV"
     gene            25020..25718
                     /locus_tag="KNP36_001529"
     CDS             25020..25718
                     /locus_tag="KNP36_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HBF0873407.1"
                     /translation="MRRALIIDDEEAVLKIITHFIEMKDMPIKIVGKATSGDEAVDKI
                     IGLEPDIVFIDIQMPIYNGLEVIEKTSHLSKKINFVVITAFNYFEYAQKALRLNVKDI
                     LLKPLDMKEFTKSVEKIIGYQYTNNDLLNEILEYINLNYSNDLKLNDCARLFLTNPSN
                     ISRIFKSNLNTTFISYLNHIRIEKSIELLENTTKSINEIAEIVGYNSLNNFYKNFKIE
                     KGMTPKVYKLNTKN"
     gene            26003..27091
                     /locus_tag="KNP36_001530"
     CDS             26003..27091
                     /locus_tag="KNP36_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873408.1"
                     /translation="MSDKVNMKNIICIAGAYLATAIGSGFATGQEILQFFASQGYMGL
                     IGALISMVLFSFLGAEVITRGRELKLKEPTRIYTFYCGKILGKFYEWFSPIFLFGILI
                     VMISGAGSTLTEYYGINPYLGRVLMAVATLITVSMGLEKLVSILGRIGPVIAVFTIAV
                     GLISLFKHFDGLSMVGEAMKNIEVTKASESPIVSGVIYNTLNIIVMIVFLTGMGASIE
                     SKKDAFWGGLLGGIVFMTAGIVMYLAMISDIGNLYMKEIPSLYLADNISPIVGVCFSV
                     ALILGIYTTAVPLLWSVTNRIVEDEHPKFKLVTTVIAILACIGGFLPFGKLVNILYPY
                     TGYMGLLILVCMVYKAITCRKKSTQSQE"
     gene            27330..28520
                     /locus_tag="KNP36_001531"
     CDS             27330..28520
                     /locus_tag="KNP36_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0873409.1"
                     /translation="MHELILISEKYKEDILDFFTDIHMHPELSFKEFRTTKAIKDLLV
                     SLDIEILDLGMETGVVGLLKGKYDGPTVALRGDIDALPIYEEVDIKYKSRYDGIMHAC
                     GHDIHTSCLVGCAYVLSHIRDSLHGNVKFIFQPAEEVNKGAKMLVERGVMENPKVDAI
                     FGLHNHPDIPCGKIGVKLGGLMAAVDTIKIEVNGFGGHGGIPNRTIDPIVASSAIIMG
                     IQTIVSRNISPLESAVISIGTINGGTANNVISEKVDMTGTCRSFSNEVRKKISENLEN
                     IVCEIARGYQATAKLDYLFDLPAVINSKEMYAIACKSVCDLYSEDAIVDPIPSTGGED
                     FSIFMEKAPGFFYWLGVGNKEQDCIYQWHNPKFKADKNSILVGTNVLCQSVINYMDKL
                     KNKI"
     gene            28611..30113
                     /locus_tag="KNP36_001532"
     CDS             28611..30113
                     /locus_tag="KNP36_001532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbgT family transporter"
                     /protein_id="HBF0873410.1"
                     /translation="MRALNVVERAGNKLPDPVTIFLLLCIIVVILSAVISNLGVEEIH
                     PSTKEVVKVVNLLEKEQIQSYLGSIVTNFQSFAPLGLVLVTMLGAGVAEKSGFMEVLM
                     KKGISKVPQKLVTVAIVFAGMLSHTAADVGFIILPPLAALVFLGIGRHPLVGMFAAFA
                     GVAGGFAANVMLSTTDVLLAGFTIPAAQMMDPSYQGNPAMNLYFAFISAIVLTFAGAF
                     VTEKFIAPRFTKYNDSTNDKDIQELSELENKGIKYALLSLLVVVVVIVALCIGDNAFM
                     KDPETGSILSSNAPLMKGIVPIITIIFLTPGLVYGKVSKKIKSDKDLVSMMGSSMSDM
                     GGYIVLAFIASQFINLFNLSNLGTILSITGAKLLAESGIPSYGLIIGFILLSGFINLF
                     VGSASAKWAILAPIFVPMFMLLDFNPALTQIAYRIGDASTNPISPLFPYFPVILAFAR
                     RYDKDIGIGTVISNMIPYSVVFTLIEIIILLLFMGIGIPLGPGGGISYVL"
     gene            30185..31441
                     /locus_tag="KNP36_001533"
     CDS             30185..31441
                     /locus_tag="KNP36_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HBF0873411.1"
                     /translation="MLKTTKISDPELYKIVADELVRQEHNIEMIASESTAPTEVLELS
                     GCVFTNKTEEGYPGARFQAGSEEADKLETLAIKRAKEVFGAEHVNVQPYSGSTANYCV
                     YSSILKPNDTVLSMRLDQGGHLTHGSAVNFLHDIYKYEFYGVDPNTGRIDYDALEAKA
                     KECRPKLIIAGASSYPRLIDYERISKVAKEVGAYFMVDMAHVAGLVAAKVIPSPVPYA
                     DFVSSSTTKTFCGPRSGIVLCKAEHAKKLDKGVFPGTLGSIHLNTVAAKAFSLLYLST
                     DKFKKIMEQVVVNAQTLASELISHGFSIVSGGTDNHIVMVDLRSKNLTGKQFEKALEY
                     VGITVNKNVIPDDPQSPFVTSGVRIGLTSISQRGLKEKEVIQIAGIMNKVAENIDNKE
                     VLDECKAEAQELISKFPLYPEGYFED"
     gene            31613..34387
                     /locus_tag="KNP36_001534"
     CDS             31613..34387
                     /locus_tag="KNP36_001534"
                     /EC_number="7.2.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-translocating P-type ATPase, PMCA-type"
                     /protein_id="HBF0873412.1"
                     /translation="MRYYNKPTKEVLKYLKTNPEIGLDDNEVEERKLRYGLNEFTIKE
                     GRTFWDELGESLTEPMILILIGAAVISSFVGELHDALGILGAIFIGISIGIITEGKSK
                     KAAHALSKLTENIEVKVLRNGKIIKISKNDLVPGDIVYIETGDMIPADGRLIQSINLK
                     LREDMLTGESDDVAKNADAVLDMEVVYSKTEIIEQDAIPAKQVNMVFGGTLVAYGRGI
                     MVVTHTGDKTEMGKIAQNLSNEDQQTPLQIKLGKLGAKIAGISGIIATLLCMFMIIQM
                     QRKGMLILDTSSILSFLQSLEPAKNAYMVCIALIVATVPEGLPTMINITLAITMQKMA
                     KINALVTKKEACETIGSVSVICSDKTGTLTQNKMMVEVAYVDGKYISGGEYQSNSYFE
                     QNCIVNSTADIEKEDNSFKYIGSATECALLLYHNDKNYNEMRKQTYLISQIPFSSEEK
                     KMSTLIRQEDSDILLSKGAPEVLLKKCSYVQQGKNIVPITPKVEKSILDEIKKLQIKS
                     MRTLGFAYKKMSNSKTEVAMTSEGELNLIGNSRSYMKEDNLVFSGFVGIVDPLREGVK
                     DSIDKAFNAGVDVKMLTGDNINTATAIGNELGLLNDGKKAVEATYIDVLTDKELREEI
                     KGISIVARSKPDTKMRIVSALQKSGEVVAVTGDGINDAPALSQADVGIAMGISGTEVS
                     KNAADIILTDDSFSTIVEGIKWGRGIYENFQRFIQFQLTVNIVAFIIAIISQLTGKDM
                     PFTTIQLLWVNIIMDGPPALALGLEPVRDYVLKRKPINRHSGIIARSMFVNIIINAIL
                     IITIVFTQSAFNILGATSEEQGTVIFSLFAFSALFNALNCREFGLNSTIPNFFKNKLA
                     LQIIVVTGIIQIIFTQVFQSFFNSVSLDFDMWIKIILFASTILLSNEFVKLILRTMKN
                     SRTMNFNSKN"
     gene            complement(34452..34637)
                     /locus_tag="KNP36_001535"
     CDS             complement(34452..34637)
                     /locus_tag="KNP36_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HBF0873413.1"
                     /translation="MFFISDIYTKSPIKFDTPLQKEAYKILQKLDIDFECVDTDEAIT
                     MEDCVQINKKLNMKMVI"
     gene            35012..36190
                     /locus_tag="KNP36_001536"
     CDS             35012..36190
                     /locus_tag="KNP36_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBF0873414.1"
                     /translation="MFSKILVKTFIRDSENVQNTDVRNKYGYVAGVVGILSNLLLFVI
                     KVFIGMLTSSIAIMADAFNNLSDMASSAITMIGFKLASKPADKEHPFGHGRIEYLSAL
                     IVAFMVMLVGLQFVKSSIERIVNPIPVKFEVIPLILLIASIMIKIWLSRFNKFMGNKI
                     DSSALKAVSLDALGDVFTSSCVVISFIVARFTNFPIDGYVGIVVSLVILYAGFSLVKD
                     TINPLLGEAPDEEMVNSIIELLLSYKYIIGTHDLIIHNYGVGRCIASIHAEIPSNIDI
                     MEIHEIIDTAEREISEKLDIYLVIHMDPICLEDKEVMSAKKELEEILKKNSLVKSMHD
                     FRIVGKGSKKNLIFDIVVNPSEFSKNMSEDDLKEDITKLVKEINPEYNCVIVVDKDFI
                     "
     regulatory      36317..36402
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            36520..39438
                     /locus_tag="KNP36_001537"
     CDS             36520..39438
                     /locus_tag="KNP36_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021362860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SrtB-anchored collagen-binding adhesin"
                     /protein_id="HBF0873415.1"
                     /translation="MKKGNRKALLISLIMILSMVVSTIYPTVSYASELGENSQIQSGS
                     TNSSTGEEKESDNKKPEQTPEKDKATDNKKPEQTPEEEKPTDNKKPEQTPEEDKSTDN
                     KKPEQTPEGEKPIDNKKPEQIPEEDKSTDNKKSEQALEDEKPLDNKNTEKTPEEDNLL
                     ENENLLKVLEEELNEENEDYGFVVKINNNTIETESMKKISFNLTYTPTSKGIQAGDSI
                     TFKVPDVFNKVNLDYTSECFDKTESNGEYTLTFRELPNGQSVMQGKIGLEAYVKKVDE
                     DTNAKIHIETTGKIESGSGDIDVEIKPGDKTDVPDAKGTLKKLVEGKKSTTVFMPVKN
                     KDINYSIQVNEKQEELKDIILYDELPEGLTLINGSVSVVTSDGKEVSDFNIEQSKNSI
                     SVNLGNIDKSYTVKYKARISDKNAKHGNKYKNVARIESDGKKIQEDDATVSIFDRGDD
                     YLLTKGHSGATNITQVGQVINYQISINDDKSPISNVVITDNIPEGMRLTTSGEAGHDF
                     RVVEIPMNGSWTPWSKEKIANNISYKVEEKRNESGQVDKVITGFTINLSKEEVESKFF
                     IAYTLKVISIEDSYINRAVLDANNSEIDKNDEINFKKNSGLISAKKEVDKKVLNSSDN
                     QIVKYKINMSTYGVYDAGQVNLLDEVNSALEISNIKYSDNLELKKEAGDGKNTIRLVN
                     KYEFKQIKEGEPVQSWVTFDADFTNVKVGETIRNVAQINGSSPPGVETTKQGYAFEAK
                     KVDALDKNVLSGAKFNLEDAFGNIVVKDLVSDEDGIIQSSIKKPGTYYLVEIMAPSGY
                     EKLKDKIKVEIGNKDIGRIVDIGNIENIRQENPPVNPPAPPNTDEPIVNPPVPPSTDK
                     PRKPSSSSDTEDTIVINPPIPPSEDIINPPIPEVLNPPVPPSEEMIETPVKQIIPIPE
                     VVKPSVSEEKNNKVKDDTLVNPPVPPKTGDSTTIIGEILLVIGAIVGLIVLRRNKNTN
                     "
     regulatory      39624..39709
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            39809..40471
                     /gene="zmp1"
                     /locus_tag="KNP36_001538"
     CDS             39809..40471
                     /gene="zmp1"
                     /locus_tag="KNP36_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease Zmp1"
                     /protein_id="HBF0873416.1"
                     /translation="MRPSKKLLIAIISIFLISSVPVSAHADSTTIQQNKDTLSQIVVF
                     PTGNYDKNEANAMVNRLANIDGKYLNALKQNNLKIKLLSGKLTDEKEYAYLKGVVPKG
                     WEGTGKTWDDVPGLGGSTVALRIGFSNKGKGHDAINLELHETAHAIDHIVLNDISKSA
                     QFKQIFAKEGRSLGNVNYLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNL
                     AK"
     gene            complement(40593..41555)
                     /locus_tag="KNP36_001539"
     CDS             complement(40593..41555)
                     /locus_tag="KNP36_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBF0873417.1"
                     /translation="MKKGYVYIILTTLFFSSMEISLKTVTNDFNPLQITLSRFFVGGL
                     VLLPFAVKRLRALSLSITKSDLKYFAFLGFMCVVVSMSLYQLAVLNTKASVVAVLFSC
                     NPVFVMLLAYLILKEKIYRHNVISLILEVLGIIVIINPLHTKLTLSGIFLTLSSAIIF
                     SMYTVFGKRKTLKFGGIVVTCFSFIFGSLEMLILVLLTKINFIADILNKNKLHVFANI
                     PIFSGYTLHNMPIMIYVFVFVTGVGYALYFMAMEATSTSLTSLVFFFKPVISPILALL
                     ILKEIIPINMVIGILLIVIGSIISIIPTIITQMHNKHVEALYKE"
     gene            complement(41725..42915)
                     /locus_tag="KNP36_001540"
     CDS             complement(41725..42915)
                     /locus_tag="KNP36_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0873418.1"
                     /translation="MISNKMQTLVANSSVIRAMFEEGKKLSDIYGEENVFDFSIGNPS
                     VEPPETIKAVINDILNEESPNLVHGYMNNSGYEDVRDAIAEHINKKDGLNLTRENLIM
                     TCGAAGGLNIILKTLLNPGDEVIAFAPYFGEYKNYTENYDGKLIEVPTNIETFEPDLD
                     ALKNAITPKTRALIINTPNNPTGVIYSEELLKNLGELLDSKQKEFNTSIYLISDEPYR
                     EIIYDGAKVPCVLKYYRNSFIGYSYSKSLSLPGERIGYIVANGQMDDFDDVMSSLNVA
                     NRILGFVNAPSLFQRVIARSLDAEVDVNIYKKNFDLLYNSLIDMGYSCVKPNGTFYLF
                     PKAPIEDDKKFCNDAKQFNLLLVPGSSFGCPGHFRVSYCVSYDKVKSSLPAFEKLAKL
                     YNLK"
BASE COUNT        17013 a         4764 c         7369 g        13901 t
ORIGIN      
        1 gtaggatata ttaataaata tgatagaata tatattataa attaaattta ttaatataag
       61 gggggaactt tgagttctta tagatttctt acattataag aaccaatact ttatgcggga
      121 gttattaaaa gtaacactta tagtaatgct tgttttgata aatgcttttt ttgtagcttg
      181 tgaatttgct atggtaaaac ttcgtagttc taggattgat accatgataa ctgaaggtaa
      241 taataatgca aaaagatgta aaataataaa agacaactta aattcctatc tttctgcatg
      301 tcaacttggt ataacacttt gttcacttgc attaggttgg atgggagaat ctacagttaa
      361 agagttaatt ttaccaatag taagtgtatt taatcttagt gaaagtatta tatatactat
      421 atcaatttcc atttcttttt taattataac aatgatggag gttgtaatag gagagttggt
      481 tcctaaagct ttagcacttt ataatacaga aaaaataatg ttgagtacat cttttttatt
      541 agtaggattt tataagttaa catatccaat aatatatttt ttcaacttaa gtactgattt
      601 atttcttaaa ccatttggat attcacaagc tgatgaggtt gatgaacccc atacaggtga
      661 cgaaataaga ctattagtag aagaaagtta taaaagtgga cttatagatg aatcagagca
      721 aagattagtt gataatattt ttgaatttga agaaaagaaa attagagaga taatggttcc
      781 tagaactgat atggtatgta tatatgaaag tgattctgaa gaaaagatat tagctatttt
      841 aaaagaggaa ggtgttacaa gatatccagt atgcagaaaa aataaagatg atatattagg
      901 ttttgtacat ataagagatt tatacaatca aaagataaat gaaaataaaa ttgaactaga
      961 agaaatattg agagatatta tatatatatc tgaaaattta actatagata aagctcttga
     1021 gagaataaga aaggaaaaac ttcaacttgc tatagttgtg gatgaatatg gtggtacatc
     1081 tggtgtggta acaatagaag atatactaga agagatagtt ggagaaattc aagatgaatt
     1141 tgacaaagaa gagactcata ttaagaaaat aggagcaggt tcttacttag ttgatggaac
     1201 tgaatctatc aactatatta ataagtattt tggacttgat atagagcatg atggatttga
     1261 cagtataggt gggtggatat cctatatgct tggttcaaat attaaagtaa accaaagtgt
     1321 aacttttgaa aattacaatt ttacaatatt agaattggat aaattgaggg ttgtaaaatt
     1381 aatcataaaa agtgtaatat aattatatca aaaaatattg gaggaattgt atgcaaaaag
     1441 tagaaggaat tatttttgac atggatggag ttttgtttga ctcagagaga atttctcttg
     1501 aattttggat ggagacgttt gaaaagtatg gatatactat gactaaggaa atttatacat
     1561 cagttatggg aagaaatcgt aaaggaataa tagaaggtct tacagatata tacgatagtt
     1621 ctgtaccaat aatagattta tatgacgaaa aaactaaaaa tatgattgaa tttatggaga
     1681 ggaagggagc tcctatcaaa ttaggagtca atgaactaat ctctttttta aaggaaaatg
     1741 gatacaaaat ggctgttgca acatcaacaa agagagaaag agcagtaaag agattagcta
     1801 aggcaaattt aaaagattac tttgatgcta tagtttgtgg agatgatgtt gtaaactcta
     1861 aaccaaaccc tgagatattc ttaaaagcag ctaaaaagat aaatgttaat ccccaaaatt
     1921 gtattgtcat agaggattcg cctatgggag ttgaagctgc atacaatggt ggtataagat
     1981 gtataaatgt accagattta aaagagccag atgagcaaat taaatcacaa tcacataaga
     2041 tacttgaaaa tttactggaa gttagagaat acctaaaaag tttgaactct aaagaatgtc
     2101 acaatctata atataaagta ttaattaaat aaattaaata taatttcttt gatttagaat
     2161 aaatccatga atatgagaaa aaataagtat aaacagctag gaggaatatt catggataat
     2221 gtaggttctc tattatattt tttatttaat tttttcttgt atggttttat aggttggata
     2281 attgaaaact tatatagtta ttataaacaa gggcattttc aagaagatgg atttttaaat
     2341 ggtccattta aaccaatgta tgcaattgca atgtcgatta taatagaggt ctcaagattt
     2401 attgacccca ataatatatt tgcattgctt ttattatgtc tagtagtgcc gacagtagta
     2461 gaatatatta caggaatact tatgaaagta tattttaata aggtctattg ggattattca
     2521 gattataagt acaatagtag aggaatagta tgtctaaagt tttctgtata ttggactata
     2581 ttgacattta ttggagttag atattttcaa gtgtatatag ttgatagttt atatagtctt
     2641 ataatacctt attggccaat tgttgtaact atacttttag taacattgtt tgtggatgaa
     2701 attcttacta taaaattttt gaggggaaat aaagatatag tagaaagata actttaaaaa
     2761 tataagttga atttagattg tagttaaaag aaagctatgt taaaatggtg aaatcattta
     2821 aaattagctt tcttttttat ttgataaaat tattttataa tatatctata agttgtaaag
     2881 ttttttatta aaattaaaat aaagtgtaga aaatggggag tgatttatga tgggtaaaat
     2941 aagatttggt attgttggga caagcaatat agcaaatata tttctaagag ctgcatctag
     3001 ggttaaagac tttgaattgg ttgctgtata ttctagaaat ttagaaaaag ctagagaatt
     3061 tggaactcta tatggagcaa gtattttttt tgatgattta gaacaaatgg ctaaatcgaa
     3121 ggatatagat gctgtataca tagcttctcc aaatgcatta cattcaaagc aaaccattac
     3181 ttgtttaaaa cacaaaaaac atgtgctttg tgaaaagtcg ttagcatcta atttaaaaga
     3241 agtcaaatca atgataaaaa cagccaaaga taataatgta ttgcttatgg aagctatgag
     3301 aattacatgt gttccaaact ttaaagcagt taaagaaaac ttatataaaa tagggaaaat
     3361 aagaagattt tttggaagct attgtcagta ttcttcaaga tatgataaat ataaaaatgg
     3421 aattatagaa aatgccttta aaaaagagtt gtcaaatgga gctttaatgg atataggagt
     3481 gtattgtata catcctatgg tgaatttatt tggtgctcca aaaactgtaa aggcagtttc
     3541 tcatatactt caaactggag tggatggaga aggttcagct gtatttcaat atgatgatat
     3601 ggatgcgata attcagtatt ctaaagtagc tgattcttat ataccatctg aaatacaagg
     3661 agaagaggga agtataataa ttgaaaagct taatctattt gaaaaagcta ttattaaata
     3721 cagagatgga agagaagaag atatatctat tccaaaagaa aaagcagagg aaaagcctag
     3781 agaaatagaa ggaatgtatt atgaacttgt agagtttata agtcttataa ataacaataa
     3841 aatagaatca aatataaatt ctcatgaaaa ttcaataata gtaatggaaa ttatggatga
     3901 gataagaaga caaagtagta ttgtttatcc agctgatagt atatagttta tattagaaaa
     3961 tataagaatt tataatatat attcttaaat aaatttaatt ttaagttaag gtaaggtgta
     4021 tacttaacca agtgttaaaa tgtcaaatta taagtatgaa aaagtgctaa aaagaaattt
     4081 atttttggcg tttttttctt tttttttaca attttgtaac agtatcaaaa aaagttttga
     4141 cgattttatt acaattttgt agttgaatat acatatcaaa actaatatga ttaataataa
     4201 cataaatttg aatattttta gaggagagaa aatatgagaa aattgatata ctttattaca
     4261 ccttttataa taggcgtagt atttttattt gggttagaca aatttcttga ttctaaaact
     4321 gatgaacttt tgagggagaa aaatctactt ccaattatgg atgatacttt aagtgatata
     4381 aaagataaag gggttacagc aaataatcat tttttaagag aaaaggatat tatgattttg
     4441 gggtcatcag aacttagtaa ttcaacaaaa caacatccaa agtactattt taatacaaat
     4501 aggagtaaaa ataaggtgtt tgcaattggg agagcctata ctcagacatt acaagatgct
     4561 gcaatattag gaagtatgaa tcctaatatt gataataaga aagttgtctt gttaatttct
     4621 atgcaatggt ttatggaaaa agacggagtc acaagtcacc attatcagtc tagattttca
     4681 ccaatacaat tttatcgatt tttagataat ccaaaaatat ctaaacaaaa taagattgaa
     4741 tatgcaaaaa aatcaagtaa gttattatgg ggaagtgacg agtataaagc agaagcatta
     4801 tatgctaagc tatatgagcc taagacattt cctgaaaaag ctgaaaaggt gcttttagag
     4861 ccttattttc aaggaagaaa gtattgtata gctcttaaag aaaagggtat tctttataaa
     4921 cgattaatta agctagataa aaagagagca acaaaaagaa aaagaccaat aaattggtca
     4981 tatgagagaa agaaagccat tgaagatgct aaaaaaagag ttggtaaaaa tccactaaat
     5041 attgataagt actattataa agagcatttt aaagatggta tagagcaata caaaggaaga
     5101 gacaaagatg taaatttatt aacatctaag gagtttgaaa attataaact gatgctaaat
     5161 gtatgtactg acttaggtat taagccagtt gttgtattaa tcccaagtat ggataaattc
     5221 tataatttga ctggtatttc tgaaaaagaa agaaatcagt actacgataa agcacaaaaa
     5281 atagcagaaa gcaaaggctt tgaagttcta aaccttaaag ataaagggtc agataagtat
     5341 tatttaaggg atgtaatgca tcttggtacg aaaggatggg tagatgtctg tgagagatta
     5401 tttaaaatat ttaaagaaca ataaagattt gttaactagt atttgtttaa ctatggttat
     5461 aatattggcg ataggagttc taacatttac tccatttaaa gaattgccat ttatttataa
     5521 cggattttaa aggagcattc ttatatgaaa attattgaag gaataaaaaa atattcaaat
     5581 acagatagaa cagcactaat gtgtaatgga gataaacttt cttataaaga tttaaatgaa
     5641 tattcagatg ctatatcagt atttctaaag gatgtataca aagaagaaga tactcctata
     5701 gtaatttatg gaaataaaga aaacatgata atggcatgta tgataggagc tttaaaatca
     5761 ggtagagcgt atgtgcctct tgatattagt tttccaattg atagagtttt tgaagtcact
     5821 aaagagataa aaccaaaggt attatttaac tttagtgatg aaaaagattt tggagatatc
     5881 aatgtaattg atatggataa attaaattat ataataaatg aatatcaggg aaaatcatta
     5941 gataaagaaa actgggtaaa agatgatgaa aatgcatata tactatttac ttcaggaagt
     6001 acaggaaagc caaaaggggt tcaaataagt tcaaacaatt tagatagctt ttcagattgg
     6061 ataagcccat atctaaacat agatggaagt gaaaaagtaa taatgaacca accagcatat
     6121 tcttttgacc tttcagttac aacaatatac cctggtctta tccatggagc tacattattt
     6181 tcaatatcaa aagatgtatt agcagactat aaagaactat ttagacaatt tagtatctca
     6241 gatatagctg tatgggtgtc aactccttct tttgcaggag tatgtataac tgaaaaagag
     6301 tttaatagta aaatgcttcc taaccttgag tcaatgatat tcataggaga agcactttca
     6361 aaaaatctta ctaaagaact tatgagtaga tttccaaaca caagaattat caatggatat
     6421 ggaccaaccg aggctactgt tggtgtaagt gtaaatgata tgactcaaaa ggctatagat
     6481 gatgaaaaaa gtcttccagt tggataccct atgtcaaatt gtaaaataaa aatacttgat
     6541 gaagatggaa atgagcttaa agaaaatgaa aagggtgaaa ttataataat tggaccatca
     6601 gtttctaaag gttacttcaa taataaagaa aagactgatg aagtattttt ctatgatgaa
     6661 atagatggtg taaagtggag agcttataaa actggagata tgggatatct tttagatgga
     6721 aatatatatt attgtggaag aaaagatttt cagattaaat taaatggatt tagaattgaa
     6781 atagaagata tagaaaataa tttgagaaaa gtacataatg taaaaaatgc agtagtttta
     6841 ccagtatata aggacgaaaa aattgcttac ttaaaaggta ttgttgagtt aaatgaaaag
     6901 aatgatttaa gtaatattaa aaatgggatg ataataaaaa aggaacttgg aaagtatata
     6961 ccttcatata tgattccaag aaatatttca ataatctctg agtttccaac aaatatcaat
     7021 ggtaaaatag acagaaagaa acttatggag gaaatttaat gattttttca caatatggag
     7081 attattttta tctttatata ttattattaa catcaatacc agcagtaatt ttaggtctaa
     7141 tgggcaagaa tataaagtat tatggtatgt tggcaagttt gtttatgata ttcttaatag
     7201 taggaattga tgtccaacta aagtacttgg taatatttat tattcttgaa gtaataatag
     7261 ttaaaggata tgaatatgta agaagaaaaa ctaaaaataa atacatatat tggggattct
     7321 tgtttgcatc aatgctccca ataataataa ataaaatatc tccagttact tcttttggaa
     7381 taattggatt tattggaata tcatacttaa atttcagaac tatacaaatg gttattgaaa
     7441 tttatgatgg agctataaaa gaagttaaaa tttcaaagat gctttatttt atgttatttt
     7501 ttccaacttt aagttctgga cctattgata ggtcaagaag atttgaacag gacttggaaa
     7561 aacaaatctc tagaaaagag tatatagaag aatacttact gccaggaata aaaaatattg
     7621 tcatgggagt aggttataag tttgttatag catttttgat aaatacatat tgggtatcaa
     7681 gaatacctaa agatatgagt tttataaata ttttaagtta tatgtacgca tatagtttat
     7741 acctgttctt tgattttgca ggatatagtt tatttgctat aggtacagga tacatatttg
     7801 gaatacaagt acctataaac tttgacaagc catttatcag taaagatatg aaagagttct
     7861 ggacaagatg gcatataagt ctttcaagat ggtttggaga ttatattttt tctagatttg
     7921 ttatgtcatc aatgagaaag aaaagattta agaaaaggac tactgctgct catgtggctc
     7981 agatgataac catgataaca atgggatttt ggcatggtct aacttggtat tatgttgctt
     8041 atggtgtata ccaaggattg gcacttgtgt taactgatat atatcagcga aaatctaaat
     8101 tttataaaaa acataaaaaa gataaatggt tcgagagagt gcagattttc attacattcc
     8161 atattgtgtg ttttggattg ctgatattct caggttattt agcttaattt taaggaggaa
     8221 aatttatgca agaaacagtt atagaaatat ttgaagatgt attagggact gatgagataa
     8281 gagaagattt agaccttaat ttatttgaga cggaactttt agactcatta gctataattg
     8341 aagttttact tgaaattgaa aatagattag ggatagagct tcaaccaact gatttagaga
     8401 gaaaagatat gtctactgta aataatttag taaaattctt ggagacaaga aaataaatta
     8461 gtagttagac tttaaatatt aatttataaa ataaaatttt acaaagtcca tctgatacta
     8521 atatttgatg gactttttta atgataatac aaagtctttt gaaaataact ttaattaagt
     8581 aaaaaattta atacataaat atgatttcat aaatcttagg tatcattgta atattatagg
     8641 agaaaaatat attatattta ggaggaaaat gaatgtcttt aaattcgata gatagaaaaa
     8701 aagaaatact taaattatta gattcaaaag ggaaggtaaa cactaaagaa ttagtaaaaa
     8761 gattagaagt atcatcagaa acaataagaa gatatttgga agaattagaa aatgaaaata
     8821 aattaaaaaa ggtatatggt ggtgctataa aaataaatta tggagtgatt gaaccagaac
     8881 atataaagag aaacaatact aacctagata aaaagcaaag tattgctaaa tatgcagcta
     8941 agtttgtaaa tgacaatgag tcaattatca tagatgaagg tactaccaat ttgcagattg
     9001 tagattatat aatatctgta aacaatttaa aaattattac aaactcttat ccagttctat
     9061 caaaattgat ttcttatgag aatcaaggtt tgtttgatgg agaagttata tttattggtg
     9121 gaaaagtaaa tttaaaacac caaaggacag catgtccaat gtcaatagat actatgaaaa
     9181 acttatacgt agataaagct tttatatcta gtgaaggtat acttgatagt tttggaatta
     9241 gtagtataga ccaaaataag gcattgttgt caaaagaata tataaaaaat tcaaaggaaa
     9301 gttttgtatt atgtgatagt tctaaaatag gaattgctag tatgtataag atagcagatt
     9361 tagaggaatt agattttgtt atttgtgatg tagaacctcc gaatgaatgg aaggataagt
     9421 taaatgagat aaatataaca tggatagaag caaaataaac ccttagtttt atataataca
     9481 actatgctca atacaactaa attcataaaa tatagtcagt tcatagatta agattagaaa
     9541 gtaaatttta gattgtaact taggatttta tgggaatatg atacaaaata aaaacaacta
     9601 aatacaacta aaaacagaaa tttaatatat atttaaccta aatatgatgt ataattaaca
     9661 tatgaaagtt atactttaaa agtaaaaaca attaaaaaca caaaaattct aaaaagaatc
     9721 tatggaggct ataaatatga aaaagatata tggagaaaaa ataaaagcag tagtattcga
     9781 ttgggctgga acaacagtag attatggatg ttttgcacct cttaatgtat ttatagagat
     9841 atttaaaaga agaggtatag atgtaacaat ggaagaagca agaaaaccta tgggaaaatt
     9901 aaaaatagac catataagag aaatgtgtga aatggataga ataaagaata tttggtcaga
     9961 taagtttggt aaagtgccaa ctgaagatga tgtaaatgaa ctttatgctg aatttgagcc
    10021 aatgttattt gagacattag aagagtatac gactccaatt cctcatgttg ttgaaactat
    10081 tgaaaagttg agaaaaaatg gattaaaaat aggttctaca acgggttata caagagagat
    10141 gatgaacata gttgaaccaa atgcagcaaa gaaaggatac tcacccgatt ttcttgtaac
    10201 accatcagaa gtatctcaag gaagaccgta tccttggatg tgctataaaa atgctgaagc
    10261 tttaggggtg tctcctatga gttctatggt aaaagtagga gatacaataa gtgatgtaaa
    10321 agaaggcgta aatgcaggaa tgtggagtgt tgctgtaata aaaggttcaa gtgagttagg
    10381 gcttacacaa gaagaagtag agaacatgga taaggaagaa ttaaaagcta agatgagtat
    10441 agtttcaaag aaatttaaag aggcaggtgc acattttgta atagaaacta tggctgagtt
    10501 agaagatata ctaataaaaa tagagaatga aactattaaa tcagattttg taccagaaaa
    10561 tgattacata ttacttacac caggaccact atctactact aaatcagtaa gagcatctat
    10621 gttaaaagat tggtgtactt gggatgttga atataataac ctagtacaag atgttagaag
    10681 aagattagta tctctagcaa cccaaaatac agataaatac acaagtgtat taatgcaagg
    10741 aagtgggact ttttcagtag aagctataat aggaagtact atttcaaaag atggtaaact
    10801 tcttgtaatt gcaaatggag catatggaaa gagaatgaaa gatatatgta attatcttaa
    10861 catacaattt gttgactgca catttaaaga tatagaagca gtggatttaa atgtagtaga
    10921 aaatttatta aaagaaaaca aggatataac acatatatca atggttcact gtgaaactac
    10981 tacaggtaga ttaaatccta tacaagaggt agggaaactt gcaaaagaat ataacaaaat
    11041 ttatatagtt gatgctatga gtagttttgg gggaattgag attgatgttg aagattttaa
    11101 tatagatttt ttagttagta gttctaacaa atgtatacaa ggagtacctg gatttggttt
    11161 tataatagct aataaagaga aattatctaa atgtaaaggt atagctaaat cattatctct
    11221 tgatgtgtat gcgcaatggg agactatgga gaaaaataat ggtaaatgga gatttacttc
    11281 acctacacat gttgtaagag ctttttatca agctttatta gaattggaag aagaaggttc
    11341 tgttgaaaaa agatatgcta gatataaaga aaatcagttt acaatagctt caagattaaa
    11401 atctttaggc tttgatactt tggtgaatga taatgctcaa tcacctgtaa taacaacttt
    11461 cttatatcct aaaaatgcaa agtttgaatt tatggaattt tatacttatt taaaagataa
    11521 tggatttgtt atctatccag gtaaattgac tgatatagat acatttagaa taggtagcat
    11581 aggtgaagtc tatccaactg atatggagag actagctgat gtaatagaaa aatttatcaa
    11641 tagatagaag aagatagtgt cttgtaggtt acagaatagt gcgcaaagcc tactccttta
    11701 ggtgtgtgag atgatagcac aaacagtgta taaaaagtat tgacagtaga atttaaagac
    11761 ttatatttta gaagtttata caatgaatat ataaacattg agtaataggg atatatttta
    11821 tttaaaccac aatctaagaa attagattta tagtttaaat aaagcatttc cctattattt
    11881 ttatgcctat ttatagaaaa taaatgatag ttgctttatt aagtattatt atcatacttg
    11941 acaacgtaac aatgttttgt tatattaggt ttaaagataa aatacggtaa agaaaggata
    12001 tcattatgaa tgaagaatta agttcactaa gatttgatgg tgttggaaaa tgtaaaggtg
    12061 gaatttttga taatgttaat atatcaggaa caggcaaaat agaaggaagt gtaaaatgta
    12121 gtaaatttga ttcttctggt tcagcaaaag tttttgggac aacagaatgt aatgaatttt
    12181 ttacatctgg tttaagtaaa gtagaaggaa acatactggc atcaaaagtt gagatatcgg
    12241 gacttcttag atgtacagga aatattaatt ctgttgaaat tgatactagt ggaattatta
    12301 atgtagaagg aagtataaaa tcggatatta ttcatggaga aggatattta aaagcaaatg
    12361 agaatataga ttgtgaaaat atcaatttaa gtggaatctt ggagtgtaat ggatttttga
    12421 attgtgaaga agttaatatt agtttaaatg gaacttctaa ttttaatgaa gttggagcaa
    12481 gtagtataaa tataaaaaag gggcatggag attattgcaa aaaatttcgt atgctagaaa
    12541 aaaagcatat ctctagtaga taattatgat gttggaaata ttgaatacag tgataattta
    12601 tcagtttcag ataattctac tgtaaaaaac agtataaagg tgggctagaa gagctatgga
    12661 agaattaata tctaagaaag atttattgag caaaactaat atatcttatg gacaattata
    12721 tagatggaaa agaaaaaaca taataccaga ggaatggttt ataaaaaaat cagcttttac
    12781 aggtcaagag actttctttc caagagataa aatactagaa agaatagagt taatattgtc
    12841 tatgaaagaa gagacttctc ttgattaaaa aatagctatg cacacttgtg actttagtca
    12901 tgagttagta gctaaaatag tcagcatata gggaaactta tatgtagaga taggatagaa
    12961 cctatccaat actacttgaa ttgctggaaa cccctaaagc taaccaaact aaaacataag
    13021 gatgaaataa acctaagtgt gaaagttacg aaagtagaaa aaattggtta gatggtataa
    13081 ggttaaatcc taagtacttt aaaatgggca atcagcaggt aagctccgaa taggaaaaac
    13141 ttcaacgact attcctcttg agggaagtac actacaagct atcggtagtg gaagtgggta
    13201 gaccttaacg gataatgccg aaggataaga tatagtctgt gcttgcatga aagtgtaaga
    13261 agttcataag agaactgcat aggtagtagc gaacttatgt gaacgacaac ctcaaaaatg
    13321 ataaaagtta agatttgcgt ttcttacgta tgttatttaa aaataaatat aaaaacctta
    13381 agaatacttg ttttaagtaa ttactatgtt aatattatgt tgggtgatga aaaatggaag
    13441 tgactcatgg tagagggtat gtgtatttag tacaatacca tatagtatgg tgtgtaaaat
    13501 atagacatcc agtattaaca aatgaaattg aagaagattt aattaatata ttaaacaaaa
    13561 tagctgaaga taataaattt caaatattag aatgtaatag tgataaagat cacatacatt
    13621 tactaataaa ttgttcacca caacactata taccagatat aataaaagca ttaaaaggtg
    13681 tatcagcaag gctgttaatg aaaaaacatg gagaacagtt gaaaaagaaa ttatggggag
    13741 gacatctttg gaatcctagt tatttcgttg ctactgtatc agaaaataca gaagaacaga
    13801 taagaaaata tattaataat cagaaaaaac aagtaaagtg aggtggcagt agtggaaaaa
    13861 gcttataagt ttagaatgta tccaaataaa aaacaacaag agttaattaa caaaactttt
    13921 ggatgttgta gatttgtata taataagtat cttgctaaaa gaatagaagt ttataaaaac
    13981 aataaagaaa cttttactta taaacagtgt agttctgatt taaccaattt aaaaaaagaa
    14041 ttaaaatggc ttaaggaacc tgacaaattt tcactacaaa acgccttaaa agatttagat
    14101 aatgcatata aaaaattctt taaagaaaaa gcaggatttc ctaaatttaa atcaaagaaa
    14161 attaatagat tttcatataa aactaacttt acaaatggaa acattatgta ttgtggtcaa
    14221 tatataaaac tacctaaact tggtatggtt aaggtaaggg ataaacaagt acctcaaggt
    14281 agaatactta atgctactat atctaaagaa ccaagtggta gatattatgt atcattatgc
    14341 tgtactaatg tagatattga agtatttgaa aatactaata atcagatagg tttagattta
    14401 ggaattaaag aattttgtat ctcaagttgt ggagacttta tagaaaatcc taagtatctt
    14461 aagaagtcat taaacaaact tgctaaatta caaagagaat tatcgagaaa gacaatcggt
    14521 agtttaaata gaaataaagc aagattaaaa gttgcaagac ttcaagaaca tatagctaat
    14581 caaagaaatg attttctaca aaaactatct actaaattaa taaaagagaa tgatattatt
    14641 tgcatagaag atttacaagt aaagaatatg attagaaatc gtaaactatc tcgcttaatt
    14701 tctgatgtgt catggtcaga atttgttcgt caattaaaat acaaggctaa ttggcatggt
    14761 agacaaattg taaaggtagg taaattcttt gcaagttcac aaatatgcaa taaatgtggg
    14821 tataaaaacg aggaaatgaa ggacttaaat ataagagaat ggatttgtcc tagttgtaat
    14881 gaaactcacg atagagatat aaatgcaagt ataaatatat taaaagaagg attaagacta
    14941 ataacaattc aaaataaata acttatgtaa gaaccgtagg aactacgggg atagcctgtg
    15001 gagaattagt aagacatatt ttagtatgca aaattctatg aagcaggaac cctgtgactt
    15061 tagtcatggg aggttcagga tattgcaaat atgtttatga aaaaggatat taataaagaa
    15121 tttgacattg attttattct cagtaaagaa gttatatgta attataccaa agaaatattt
    15181 caaaatttat ataaaaaaga acaaagcata ggtaaaaaag aactgcttat attgagcata
    15241 atagagaagt ttttagttaa atctataata acttttgaag agttaaaatt gatagtgaat
    15301 ataatagaag aaaattttac atcaatatac aatgaaagtg gaaagattta tttgtttaga
    15361 aagtttggag ttccattcgt agtaggatgt ctggattata aaaaagtaaa gtttgaaaaa
    15421 gatgtagtta agattattga ggttgacttg acaaaagaaa taaatgatat aagtataaag
    15481 ttatcatagt gtattatctt atataatgta ttataataat ctacttaaaa tacactttat
    15541 ttaaatattt agtttaaaga tgagatttta tgtgagtgtg taaaagttaa agatagattt
    15601 aagtaggtta tagggattag taaacaataa aatgaaccat gatgaactac tataaattgt
    15661 atttaaacta cattttctac ttatagtaat atcaatggtt cattttattg ttattaagat
    15721 aatacagtat ttataaaaat acttgatata aatatagtaa attgtttaaa tagaattatt
    15781 gccttaattt attcaaataa tgagttttta aaatctaaga aatatccttg tggatgaaga
    15841 catacaggac aagctttagg agcttcttta cctatatgta tatggccaca atgtgtacat
    15901 atccattgta tatcttcatt tcttctgaat aaagtacctt cttctaaatc agtagcatat
    15961 ctaccaaatc tatcaccatg aactttttct atttcagcta tattttcaaa taacttagct
    16021 atagattcaa atccttcttc acgtgctgtt tttccaaagt ttttatatac atcatcccac
    16081 tcttgaagct cattatgttg tgcagcttta aggtgttgtg ctgtcttgtc atataaatct
    16141 acagggtatg ctcctgatat acttatattt tcaccagcaa attcttttaa tttagaaaag
    16201 aattgttttg catgtgattt ttcttggtca gcagtgtaat taaataaaga ctctattata
    16261 tataatcctt ctttttttgc tacagatgca gaaatattgt atctatttct agcttgactc
    16321 tcacctgcaa aagctcttaa taaattttct ttagttttac tatcttttaa attcatattc
    16381 tacctctcta tcacaataaa tttttacaat atttgattct ttttatttat tattccaata
    16441 ggagatataa ttatgctcaa tttagtcagc atttttaaaa ttatcattaa ttttttttaa
    16501 aattctaaga aattcttgtt tttcattttc tgtaatatta tggtatgccg tctctttaac
    16561 ttgtgttgag atgctattaa aagtatcttc tataagcagt gccttttttg taagctttat
    16621 atacgtgata cgtttgtcat ttgtacattt ttgtctttct aaatatccta ggtttataag
    16681 tttattaacc aacactgtaa cagtggattt atcttttcct attttagctg caatttcttt
    16741 cattgtaagt attccattat tttcataaag tgcagttaaa atatttccat gagtaggtat
    16801 taactcacct aaaccatttt tactgagttt attttcaatg aatttaatca tactagcctt
    16861 tgttttactt atgaaatgta caatatattt atcttccata aattattctc caatctttaa
    16921 tctatttaaa ttagtttgac ataaaactat ttataaacta taattagttt aacataaaac
    16981 taaatgtatt gggaggaaat ttatgaataa aaaatttaaa tcactatata ttacagaaga
    17041 agaaggaaat tttagaagaa atatagttga aagagaagtg gatacattgc cagaaggcga
    17101 agttctaata aaagtaaaat attcttctct aaattacaag gatgcacttt ctgcaaatgg
    17161 taataagggt gttacgagaa agtatcctca tacaccagga attgatgcat ctggtatagt
    17221 agaatctagt agttgtgatg attttaaaat tggagaagaa gttttagtaa caggttatga
    17281 cttgggaatg aatacttctg gtggtttttc agaatacata agagttcctt ctagttgggt
    17341 agttaaactt cctaaaaatc tttcactaaa agaagcaatg gattatggta cagcagggtt
    17401 tacagcagct ttatctgtgt ataaatttat agattctgta gacaagaata tgggagatgt
    17461 attagtcact ggtggtactg gaggagttgc tgtaattgca actaaaatat tgattaaatt
    17521 aggttattca gttgtagttt caacaggaaa attagaagaa caaaaagaag tattactaaa
    17581 cttaggtgtt aaagatgtta tacataggtc agaagtggat gataactcag gaagacctct
    17641 gcttagacca agatgggctg gagtaataga tacagtagga ggaaatactc tagcaacagc
    17701 aataaagaca actaattatt gtggagcagt aacaacttgt ggtaatgcag gaggagttga
    17761 ttttacaagt tcagtatatc catttatctt aaagggaatt actttatatg gtatagattc
    17821 tgtggattgc ccaatgaact taagattaaa aatatgggat ttattatcaa atgaatggaa
    17881 attagatgat ttagatgata tggtaaatgt agtatcattg gaagagttaa atgatagtat
    17941 agattcaata atggcaggaa aacatgttgg aagaacagta gttgatttag aaaaaatata
    18001 ggtgaataaa tttataatta ggattatagg ttttaagcaa aaatgagata cttgaaattt
    18061 acttgtgagt atctcatttt tttatgtaaa aagatttatg tagatgtttg tgtaaaaaga
    18121 ttattcatga acaattaatt caaatacatc tggtcttgaa tagtgacctt ctgaatcaaa
    18181 atctagtcta ctaagtacta ttttttctag gtctaaatca gctattagca tttcttcttt
    18241 attgaaaata ggacctgcta catattttcc aaaagggtca actatacaac ttcctcctgg
    18301 acacataatt tctggttctg catctagctc tttatagtag ttaaggtcag ttggatacat
    18361 atttttttca acatattgat tgcatccaat tacaaaacat cttccttcta aagcaatatg
    18421 cttcatagtt gcttgccact cttctcttga atctgcagta ggggctatgt aaagttttac
    18481 acccttagca taaagagctg ttctagctaa tggcatataa ttttcccaac aaatcaacga
    18541 acccattttt ccatatggag tatcaactac tgtaagagta cttccatctc cttctcccca
    18601 aatacatctt tctgttcctg taggtttaag ttttctgtgt ttaccaatta gcttaccttc
    18661 tggagagaaa aataagtttg tgcaataaag ggtacaattt atatcattac catctctttc
    18721 tgttataccc attgatagat atactcctgc ttcttgtgct gcttttccta ataaatctgt
    18781 tgtagcacta ggaactggta cagaattatc atagtatctt ttccaatctt ctctaccttc
    18841 cattgttcta cttccaacaa caaatccaaa tgaaagacct cttggatatg caggtatgaa
    18901 tgcttcaggg aaaactacga tatttgcccc ttttctacca gcttctttaa ttaatcctaa
    18961 tgctttttca acagtttttt ctaaatccat tatgactggt gacgcctgga caacagcaat
    19021 tcttacattt ttattttcct tgctcataaa aacctcctaa aaaatattta aattttttgc
    19081 attgaataga ttacatgaga tgttatttga gaactaagat acttatattg tgaataataa
    19141 tgtaactgta tatttaaaat aatacatcat gatttaaaaa attacaattg tacagatata
    19201 attgagttta gatatttaaa tttaacaact tataatattt tttcaattag tataaagcct
    19261 attaatttgt cttatttaca atgaatagta tttacttctt ggcaaacaat aattaaaaat
    19321 aaaactttta tatgattaaa ctctaaagaa aaagtttata aagaagataa tataattaag
    19381 cagaaaataa tgaaaaaaat ttattaaagt agacaacgta aggagaattt tatgaaagaa
    19441 aaaatttatt acaatggaaa tatcatcaca atggaagatt caatatgtgg agatgctatt
    19501 cttataaaag acaaaataat aaaaaagata ggaacaaaag aagaagtatt tgctttgaaa
    19561 aataaagata cagaaattat agatttacaa ggtaagacat tgatgccatc ttttatagat
    19621 tcacatagtc acttgatagc ttttgctact actctaaagc tagttccttt agaagatgca
    19681 accagtttta aagacatagt aaaaaaaata caggatttca aagagtcgaa taatataaaa
    19741 aaaggagact ggataattgg attttcatat gataataatt ttttagaaga aaataagcat
    19801 ccagataaga gtgtactcga tagtgcatct tcagaaaatc caatactaat ttcacatgct
    19861 tctggtcata tgggagttgc aaatacattg gggttaaaac agcttggtgt taccaatgaa
    19921 acacgtgacc cagaaggtgg acatataggt agagtagaag gcagtgaaga accaaatgga
    19981 tatttagaag aaaatgcatt ttttaatgta gcatctaaaa taaaacaacc atcatcaaat
    20041 gagattttta attcaattga aaaagcacag aacatatatc taagctatgg tattacaaca
    20101 gctcaagaag gtttaatgga agaaaatcaa tttaacattt taaaagcaat ggcaaatcaa
    20161 aataaattaa aaatggatgt tgtaggatat gtaaatttga aaaaaagtaa gtctgtagca
    20221 gataataata gggagtttat aaaaaaatat ataaatagat ttaaaatagg aggttataag
    20281 attttcttag atggttctcc acaaggtaag acagcatggt tgagtagacc atatgaaaat
    20341 tcagatgatg gttattgtgg atatcctata tacaaagatg aagaagtaga aaagtttata
    20401 gatatttcac taaaagaaaa gatgcaactc ttaactcatt gtaatggaga tgcagcagca
    20461 gaccagttga tagatgcgtt tgagaaagtt ttaaatttaa aagagcaaag tagtgaaaat
    20521 catataagac cagttatgat acatgctcaa acagtaagag aagaccagat tgatgatatg
    20581 aaagtaataa atatgatacc ttcatacttt gtagctcaca catattattg gggtgatatt
    20641 catatcaaaa accttggaga agatagagcg tttaagatta gcccacttaa aacaactata
    20701 gaaaagggat taatttacac tcttcatcag gatacaccag taatagcacc taatatgctg
    20761 gaaacagtat ggtgtgctgt caatagaatt acaaaaaaag gtatacaaat aggagaaaat
    20821 gaaaagataa gcccattaga tgctttaaag ggtgttacta taaatgcagc atatcaatat
    20881 tttgaagaag ataaaaaagg ttcaattaaa gaagggaaat tagctaattt gataatctta
    20941 gatgaaaacc cacttacaat cgaccctatg aaaataaaag atattaaagt attgcagact
    21001 ataagagaag gagaagtatt gtattctttg aagtagatga aagttagata ttttataatc
    21061 tataaaaaat agttttatat aataagttag gtagaattaa ataagattac agttaaatca
    21121 acaattatat ttttattaaa ttttaattat tgtattgaag atttataagt ataattttat
    21181 tgattctacc tttttaaata actgtcgatt tattaaagtt atctatgtac tatattaaac
    21241 aattaagtag ttattaattg aacttattag tttattaaaa aactatgtat attactttgc
    21301 agtaagactt tggaactaaa tctataatag caaatttaaa tttattaaat agattacctt
    21361 ataacatttc atataaaata tattgtgaat ctgagaaaat tactattttt ctttgagtat
    21421 tttttgtaag cagttctaaa agattcaatt tcatacctat tacttgaatc attcattaaa
    21481 ataattctaa tttaaaaaat aattctatcc aaataataga tatataggac tatgttataa
    21541 tataaaaaaa tttatataaa agttaataac tatacaagat tgataaagaa aaagtcaaaa
    21601 tagataattg attagcaaaa tagatataat tataatgaag ttaaatctag caatattctc
    21661 ctaaaattaa attacattta tttaattaaa tataatttga caatggacaa aaaagtgagt
    21721 aaaatataaa taaaataaaa ataacaggtt cggataaaga aaaaggtttc ttaacctcaa
    21781 gcataaagta tattatctaa gttatttgag attaagagat aaatccaatc ttaggtactg
    21841 aggaggaaaa aatgcttgat ataaaaagaa taagagaaaa tttagattgt ataaaaaaag
    21901 caatggaaag aaggggcgaa aaagacttta accttgatga agtagttaag ttagatgatg
    21961 aaagaagaaa gattcttcaa gaagttgaag ttatgaaaaa tgaattaaat acagcatcta
    22021 aaaatatacc aaatcttata aaagaaggta aagatgtaga aaatgaaaag attaaactaa
    22081 aagagttatc tgataaaatt aaggtaatag accaaaatct taaagaagta gaagataaga
    22141 tggaatacct attaatgaga ataccaaatg taccacatcc agaagtacca caaggtgaaa
    22201 ctgatgaaga taatgttgaa gtaagaactt ggggaaagac tactaccttt gattttgaat
    22261 ctaaggctca ttgggaaatt ggaacagaat taggtatact tgattttgaa acagctagta
    22321 aaataactgg ttcaagattt actctttaca aaggattagg tgctagatta gagagagcat
    22381 tattaaattt ttacttagac acgaatacaa aagtaaatgg atatacagaa gttattccac
    22441 catttatggc aaatagaaat agttttttag gtacaggaca gttacctaag tttgaagaag
    22501 atatgtttaa aatagaaggt atggactatt ttatgattcc aacatcagaa gttcctttaa
    22561 ctaatataca tgctaatgaa atacttaaat ttgaacaatt accgataaat tatacagctt
    22621 atactccatg ttttaggtca gaagctggtt ctgctggaag agatacaaga ggtttagtaa
    22681 gacaacatca gtttaacaaa gtagaaatgg ttaaaatagt tgcaccagaa gaatcttaca
    22741 atgagttaga aaagcttact aacaatgcgg aaactatgct acaattattg aatctgcctt
    22801 atagggtagt aaagatatgt acaggtgatt taggatttac ggcttctttt aaatatgatg
    22861 tagaagtttg gatgccaagt tacaataggt atgttgagat ttcatcttgt tcaaactgcg
    22921 aagatttcca agctagaaga gcaggaataa gatttaaaag agataaagat tctaaagctg
    22981 aatatgtaca cacattaaat ggctctgggt tagctattgg aagaagtgtt gcagctatat
    23041 tagaaaatta tcaacaagaa gatggttctg tggttgttcc tgaagtttta agaccatata
    23101 tgggagtttc tgttattaag taagagttaa attatgtatt tttaagcaat acaataatat
    23161 agaggtaata aaaaataatt aatataaaag tgatacaata atatagaagt aataaaaaaa
    23221 tagttaatat aaaagtgata caataatata gaagtaataa aaaaaaataa ttaatataaa
    23281 aatgtgtaca aactaatgaa tattgatata gtaagctatc atatgaaaga gtatgtacac
    23341 atttttttta ctaatttttc acaatatgaa cataaataat ttacaggaaa ggaatctttt
    23401 atgaaaattc aaaatactga gtggggatat attgaatgga aacatactta tgatgaaaat
    23461 aatccaaaac aagctatgaa tatatacatt gcagtaacta tgcctggtaa gaaacatttt
    23521 aatcatgttc attatggtca agagcagatg atatatattt tagagggaga gggtttgtat
    23581 attataaatg gagtttggaa gccattttat caaggtatga ttttttatat agaatctggt
    23641 agcacacatg aaactataaa tacaggtgat agagaaataa aagaacttat tgtttcaaat
    23701 aatgtagatg atgtaggaga gagtgaagtt atagatatta atcctaataa ttatttaaag
    23761 aagaccttga taaattatag tgaaagtaca ttaaatttgt atgcagcagt agaatcaatt
    23821 cgtggtcaat ttatagaccc gtttaaaatt ccattaatta tatatgatga ttcatggaat
    23881 atagttttaa aaaatcctta ttttccactt ttttgttttg aaaaatgtaa tcctatgaaa
    23941 tttcctcaaa attgtgattg tatgaatcaa aaaagtagca atcaatttgt atgtgaatat
    24001 gggataacta tatataatat accaatactg tacaaaagca atagcatagg tgttataaga
    24061 ggagggtatg tactattatc tgatttgaat ttagatacag agcataataa tttatatgat
    24121 attccagagg gagctgctag aagtataaaa cgcctcttga aacaaatatc taaaaatata
    24181 ataaattttt gctcttttaa tgatataaga aaggatttac aagaaaaaga gaagactata
    24241 gcaagaacat atcattatgg agagcaactt gaaatgaatt taaaagtagc tcaagatatg
    24301 gttactaatt taagaataaa tcatcacttt ttatttaata cattaaattc aatggcaagc
    24361 atagcactag atgatggtag ttatgatttg tatagtgcaa taatagattt atcaagaatg
    24421 tttagatata caatgaggtc tgatttaaga tttgtagaat tagaatctga aatattatac
    24481 attaaaaatt atttgaattt acagaaatta cgttatggag atgcacttaa agtaaaatat
    24541 cttattccag agaagttata taacctttct gtgcctttta actttattca acctattgta
    24601 gagaatgcat ttacacatgg atttagagat attgacacag aaaagcgaat tgaaataatt
    24661 gcaagattag attctcagta tgctattata gagattcata ataatggaac tatcttagat
    24721 ggaaataata tagacaaaat aaaggcaggt attcgtagta ataatggtca tggtttgtct
    24781 ttaatatata caaaattcac atctgcttat ggaaataatt ttgatatgga tataaagtcg
    24841 agtgataatg aaggaactta cataatgatt aaaattccta ttgaaaatta taaggagtat
    24901 gtatagaact tgtgaaaaat taataagttt tataaatgtt aagaaatata ttagatgttt
    24961 ttatgttgtt ttatatatct tactttttta tattattaag ctaaaaggga ggtattctca
    25021 tgagaagagc actaataata gatgatgaag aagctgttct aaaaataata acacatttta
    25081 tagaaatgaa agatatgcca ataaaaattg ttggtaaagc aacatctggt gatgaagcag
    25141 tagataaaat cattggttta gagccagaca tagtttttat agatattcaa atgccaatat
    25201 acaacgggtt agaagtaata gaaaaaacat ctcatttatc taaaaaaata aactttgtag
    25261 taataactgc atttaactat tttgaatatg ctcaaaaagc tttgagatta aatgtaaaag
    25321 atatactcct taaaccattg gatatgaaag aatttactaa gtctgtagaa aaaattattg
    25381 gatatcaata taccaataat gatttattaa atgagatact ggaatatata aatctaaact
    25441 atagcaatga cttaaagtta aatgattgtg ctagattatt tttaaccaat ccatctaata
    25501 tatctaggat ttttaaaagt aatttaaata caacttttat atcatatcta aatcatataa
    25561 gaatagaaaa atctattgag ttacttgaaa atactacaaa aagtataaat gagattgcag
    25621 aaatagttgg atataatagc ctaaataact tttataaaaa ctttaagata gaaaaaggaa
    25681 tgactccaaa agtttataaa ctgaacacta aaaattgaaa ttgataaata aaaagtcaat
    25741 atagataatt gtttgagtgt gtctgaataa gtatacttta attatgataa aaattaaagc
    25801 gctttaaaca tatttaataa tattaaacct tataaaagct gtacctattt atataaaaaa
    25861 atatatataa ataaaaagaa aaagatatac aaaataaaaa aagtgaatta aatactgttt
    25921 caaaaagaca gaattttcat ttaatttact gagagtttat atttcttaaa ggaaggtaac
    25981 tttataatgg aggtaattta atatgtcaga caaagtgaat atgaaaaata ttatctgtat
    26041 tgcaggcgct tatctagcaa cagcaattgg ttctgggttt gctactggtc aagaaattct
    26101 acaatttttt gcctcacaag ggtatatggg tttaattgga gcattaatat caatggtatt
    26161 gttttcattt cttggtgctg aagttataac tagaggtaga gaattaaaac ttaaagaacc
    26221 aacaagaatt tacacttttt attgtgggaa gattttagga aaattttacg aatggtttag
    26281 tccaatattt ttatttggga ttcttatagt aatgatttca ggtgcaggct caactttaac
    26341 tgaatactat ggtataaatc cttacttagg aagagtattg atggctgttg ctactttaat
    26401 tacagtgtct atgggtttag aaaaattagt aagcatactt ggacgtattg gaccagtgat
    26461 agcagtattt acaattgctg ttggattaat aagcttgttt aagcattttg atggtttatc
    26521 tatggttgga gaagctatga aaaatattga agttacaaaa gcatcagaaa gtccaatcgt
    26581 ttctggtgta atatataata cattaaatat tattgtaatg attgtttttt taacaggaat
    26641 gggagcttct attgaaagta aaaaggatgc tttttgggga ggtttattag gtggaatagt
    26701 gtttatgact gctggtatag ttatgtattt ggctatgatt tcagatatag gaaatttgta
    26761 tatgaaagaa ataccatcac tttatttagc agataatata tctcctattg taggtgtatg
    26821 tttttcagtt gcattaatat taggtatcta cacaacagct gttccacttt tatggtctgt
    26881 aaccaataga attgttgaag atgaacatcc taaatttaaa ttggtaacaa cagtaatagc
    26941 tattttggct tgtataggag gttttttacc gtttggtaaa ctagtaaaca ttttatatcc
    27001 atatacaggt tatatggggc ttttaatttt agtctgtatg gtgtataaag caattacatg
    27061 tagaaaaaaa tcaacacaaa gtcaggaata gagccactta ttaatagttt ttatttaaag
    27121 aaatttttta tataatccga atttaaaaag tcaaaatagt taaataaatt gtaaaatatg
    27181 ataatatatt taattaaaat aatatagtaa aatataaata taaactaaaa ttaaatttat
    27241 aaaaaatatc tttataaaga ttattaactt atataatttg tagttaaatt ataaaaaata
    27301 aaaaaataaa attttggaga ggtgttagta tgcatgaact tattttaatc tcagaaaagt
    27361 ataaagaaga tattttagat ttttttacag atattcatat gcaccccgaa ttaagtttta
    27421 aagaatttag gactacaaaa gctataaaag atttattagt gagtttagac atagaaatat
    27481 tagatttagg aatggaaaca ggagttgttg gattattaaa agggaagtat gatggtccca
    27541 cagtagcact aagaggagat attgatgcat tgccaatata tgaagaggtt gatattaagt
    27601 ataaatccag atatgatggt ataatgcatg catgtgggca tgatatacac acgtcttgcc
    27661 ttgtaggatg tgcatatgta ttgtctcata ttagagatag tcttcatgga aatgtaaagt
    27721 ttatatttca accagccgaa gaagtcaata aaggtgcgaa gatgctagtg gaacgaggag
    27781 taatggaaaa tccaaaagtt gatgctatat ttggacttca taatcatcca gatatacctt
    27841 gtggaaaaat aggtgttaag ttaggtgggt taatggcagc agtagacact attaagatag
    27901 aagtaaatgg atttggaggt cacggaggta tacccaacag aacaatagac cctatagtag
    27961 catcaagtgc aattataatg ggtattcaaa ccatagtaag cagaaacata agtccattag
    28021 aatcagctgt tatatcaata ggtactataa atggagggac tgcaaataat gtaatttcag
    28081 aaaaggtaga tatgacaggc acatgtagaa gctttagtaa tgaagtacga aagaaaatat
    28141 cagaaaattt agaaaatata gtttgtgaga tagctcgtgg atatcaagca actgcaaagc
    28201 tagattattt atttgattta ccagctgtta taaatagtaa agagatgtac gcaatagctt
    28261 gtaagtctgt gtgtgatttg tattcagaag atgctatagt tgatccaata ccttctacag
    28321 gaggggaaga tttttctata ttcatggaaa aagccccagg atttttttac tggttagggg
    28381 taggcaacaa agaacaagat tgtatatatc agtggcataa tcctaaattt aaagctgata
    28441 aaaattctat attggtaggt acaaatgtac tatgtcagtc tgttataaat tatatggata
    28501 aattaaaaaa taaaatttaa gatagagcat tctggagata aagtttatga gggggtatta
    28561 gtttgaggaa aattaattca caggaaaaaa acaaagatag tggattattg atgagggcac
    28621 taaatgttgt agagagagca ggaaataaac ttccagaccc agtaaccata tttttattac
    28681 tatgtataat tgttgtaata ttgtcagcag ttatatctaa tttaggagta gaagaaatac
    28741 atccttctac aaaagaagtt gtaaaggtag taaatctact agagaaagag cagattcaat
    28801 catatttagg tagcatagtt acaaactttc agtcatttgc tcctttagga ttagtactgg
    28861 ttacaatgct tggagcaggt gttgctgaga aatctggatt tatggaagtg ttaatgaaaa
    28921 agggtataag taaagttcca caaaaacttg taactgtagc aatcgtattt gcaggtatgt
    28981 tgtcacatac agcagcagat gtaggattta taatattacc accacttgca gcacttgtgt
    29041 ttttaggaat tggaagacat cctcttgtag gtatgtttgc agcttttgca ggtgttgcag
    29101 ggggatttgc agcaaatgtt atgcttagta ctacagatgt attgttagct ggatttacaa
    29161 taccagcagc tcaaatgatg gacccatctt accaaggcaa tccagcaatg aatctttatt
    29221 ttgcttttat atcagcgata gttttaactt ttgcaggagc atttgtaact gaaaaattta
    29281 tagctcctcg ttttacaaaa tataatgatt caacaaatga taaggatata caggaattga
    29341 gtgaacttga aaataagggt ataaaatacg ctttattatc attgttagtt gtagtagtag
    29401 tgatagttgc cttatgtata ggtgacaatg catttatgaa agatccagag actggttcta
    29461 tactatctag taatgcacct ttaatgaaag gtatagttcc tataatcact attatatttt
    29521 taactccagg attagtgtat ggaaaagtaa gtaagaagat aaaaagtgac aaagatttag
    29581 tatctatgat gggtagtagt atgagtgata tgggtggata tatagtccta gcatttatag
    29641 catcccagtt tattaattta tttaatctta gtaacttagg aacaatttta tcaataacag
    29701 gagcaaaatt actagcagag tcgggaatac ctagctatgg attgataata ggatttatat
    29761 tgctatctgg atttatcaat ttatttgtag gaagtgcttc tgcaaaatgg gcgattttag
    29821 cacctatatt tgttcccatg tttatgctac tagactttaa tccagcatta actcaaatag
    29881 cttatcgtat tggagatgct tcaacaaatc caataagtcc actttttccg tattttccag
    29941 ttatattggc ctttgccaga agatatgata aagatatagg tataggtact gtcatatcga
    30001 atatgattcc atactcagtg gtatttacat taatagaaat aataatattg ttactattca
    30061 tgggtattgg cataccatta ggacctggtg gaggaatatc ttacgtttta tagaccgtta
    30121 taataaattt atcaatgaag attaaactaa taaaatatat tctttaatta agaggaggat
    30181 tattatgtta aaaacaacaa aaatttcaga cccagagtta tacaagattg tagctgatga
    30241 gttggttaga caagaacaca atattgagat gatagcttct gaaagtacag caccaacaga
    30301 agtacttgaa ttaagtggat gtgtatttac aaataaaaca gaagaaggct atccaggggc
    30361 tcgttttcaa gcaggttctg aagaagcaga taaacttgaa accctagcaa taaaacgtgc
    30421 aaaagaagta tttggagcag aacatgtaaa cgtacaaccg tattcaggtt ctacagctaa
    30481 ctattgtgta tattcatcaa tattaaaacc aaatgacact gttttaagta tgcgtcttga
    30541 ccaaggtgga cacttgacac atggtagcgc agttaatttt ttacatgaca tttataaata
    30601 tgaattttat ggggtagacc caaatactgg acgtatagat tatgatgctc ttgaagcaaa
    30661 ggcaaaagaa tgtagaccaa aacttataat tgcaggggca agttcatatc caagattaat
    30721 agattatgaa agaatatcaa aggttgcaaa agaagtagga gcttacttta tggtagatat
    30781 ggcacatgtt gcaggattag tcgcagcgaa agtaatacct agtcctgtac cttatgcaga
    30841 ttttgtttct tcatctacga caaagacttt ctgtggacca agaagtggta ttgtactttg
    30901 taaagcagaa catgcaaaga aactcgataa aggtgttttt ccaggaacat taggttctat
    30961 acatcttaat acagttgcag caaaagcctt ttcactatta tatttaagta cagataaatt
    31021 taaaaagata atggagcaag ttgtagtaaa tgctcagact ctagcttctg aactgatttc
    31081 acatggtttt agtattgtaa gtggaggtac tgataatcat atagtaatgg ttgacttaag
    31141 aagtaagaat cttacaggaa aacaatttga aaaagctctt gaatatgtag gaataacagt
    31201 taataaaaat gttatacctg acgacccaca atcaccattt gtaactagtg gtgttcgtat
    31261 aggtcttaca tcaatatctc aaagaggtct gaaagaaaaa gaagttatac agatagcagg
    31321 gataatgaat aaggtagcag aaaatattga taataaagaa gtattagatg aatgtaaagc
    31381 agaggcacaa gaacttatat ctaagtttcc attatatcca gaagggtatt ttgaagatta
    31441 aatattttga tttgtatagc tcacaattta taaagcctgt aacataaaat ttaataatat
    31501 ataaccacta taaggtgttg attaatcaac accttatttt ttttgaaaag taatatacaa
    31561 gctatcataa gcatataatt ccttatagat aattaacaag ggggataaag ttatgaggta
    31621 ttataataaa cctaccaaag aagtattaaa atacttaaaa acaaatccag aaattggact
    31681 tgatgataat gaggtagaag aaaggaagct tagatatgga ttaaatgaat ttactataaa
    31741 agaaggtaga acattttggg acgagttggg agaaagtttg acagaaccta tgatattaat
    31801 tctcatagga gcagcagtaa taagttcttt tgtgggagaa ttacatgacg cattaggtat
    31861 tttaggggct atttttattg gaatttctat aggcataata actgaaggaa aatctaaaaa
    31921 agcagctcat gccctgtcaa aattaacaga aaatatagaa gtaaaggtgc ttagaaatgg
    31981 gaagataatt aaaatatcaa aaaatgattt agtaccagga gatattgtat atatagaaac
    32041 tggggatatg ataccagcag atggaagact tatacagtct ataaatttga aacttagaga
    32101 agatatgcta acaggagaat ctgatgatgt agctaagaat gctgatgctg tattagatat
    32161 ggaagtagtt tattctaaaa cagaaataat cgaacaggat gcaatacctg caaagcaagt
    32221 caatatggta tttggaggga ctcttgtagc atatggtagg ggcataatgg ttgtcactca
    32281 tactggtgat aagacagaga tgggtaagat agcacagaat ttatcaaatg aagaccagca
    32341 aactccactt caaattaaat tagggaagtt gggtgctaaa atagcaggaa tatcaggcat
    32401 aatagctact ttattgtgta tgtttatgat tatacagatg cagagaaaag gtatgttaat
    32461 tttagataca agcagtatat tatctttctt acaatcatta gaacctgcta aaaatgcata
    32521 tatggtttgt attgcattaa tagttgcaac tgttccagaa ggtttgccaa ctatgataaa
    32581 tattacctta gctataacaa tgcaaaagat ggcaaagata aatgcattag taacaaagaa
    32641 agaagcctgt gaaactatag gttctgtttc tgtaatatgt tccgacaaaa cagggacttt
    32701 aacacaaaac aaaatgatgg tagaggtagc atatgttgat ggtaaatata taagtggagg
    32761 agagtatcaa agtaatagct attttgaaca aaactgtata gtaaattcaa ctgcagatat
    32821 agaaaaagaa gataattcat ttaaatatat aggaagcgca acagagtgtg cattactttt
    32881 atatcataat gataagaact ataatgaaat gagaaaacaa acgtatttga tatcacaaat
    32941 accatttagt tcagaagaaa agaagatgtc aacattaatt cgtcaagagg attcagatat
    33001 attactttca aaaggtgctc cagaagtatt attaaaaaaa tgttcttatg tacaacaagg
    33061 aaaaaatatt gttccaataa ctccaaaagt agaaaaaagt attttagatg agattaagaa
    33121 gttacaaatt aaatctatga gaacattagg atttgcttat aaaaaaatga gtaattctaa
    33181 aacagaagtt gcaatgactt cagaaggtga attgaattta ataggaaatt caagaagtta
    33241 tatgaaggaa gataatttag tttttagtgg atttgtagga atagtggacc cattgagaga
    33301 aggggtcaaa gattccattg ataaagcatt taatgcagga gtagatgtaa aaatgcttac
    33361 aggagataat ataaatacag caacagctat tggaaatgaa ttaggattat taaatgatgg
    33421 gaaaaaggca gttgaagcaa catatataga tgtattgaca gataaagaat tgagagaaga
    33481 aatcaaagga atatctattg ttgcaagaag taaaccagat acaaaaatga gaatagtttc
    33541 agcacttcaa aaaagtggcg aagttgtagc tgtaacaggt gatggtataa atgatgcccc
    33601 agcacttagt caagcagatg ttggaattgc aatgggtatt tcaggaacag aagtatctaa
    33661 aaatgcagca gatataatat tgactgatga tagctttagt actatagtag agggaataaa
    33721 atggggaaga ggtatatatg agaactttca aagatttata cagtttcagc ttactgtaaa
    33781 tatagtagca tttataattg ctataatatc tcaacttact ggtaaggata tgccatttac
    33841 tacaatacaa ttattatggg taaatataat aatggatggt cctccagccc tagcattagg
    33901 attagaacct gttagagatt atgtattgaa aagaaaacca ataaatagac attctggaat
    33961 aatagctagg tctatgtttg taaatattat tataaatgca attcttataa ttacaattgt
    34021 atttactcaa tcagctttta atatattggg agctacatca gaagaacaag gtactgttat
    34081 attttcttta tttgcattca gtgccctttt taatgcatta aattgtagag agtttggttt
    34141 aaatagtaca ataccaaatt tctttaaaaa taaactggca ttgcaaataa tagtagttac
    34201 agggataatt caaataatat ttacacaagt gttccagagt ttctttaatt ctgtttcttt
    34261 ggactttgat atgtggataa agataatact atttgcatcc actatcctat tgtcaaatga
    34321 atttgtaaag ctaattctta gaacaatgaa aaatagtaga actatgaact ttaatagtaa
    34381 aaattaattc ttatgaaacc gtaaagtact atatattgta actttgcggt ttttgtttgt
    34441 ttaatgttgt tttatattac cattttcata tttaattttt tattaatctg aacacaatct
    34501 tccattgtaa ttgcttcatc tgtgtcaaca cattcaaagt caatatctaa tttttgtaat
    34561 attttatatg cctctttttg caaaggagta tcaaatttaa taggtgattt tgtgtaaata
    34621 tcactgataa aaaacatgat ttatttcatt cctttccatt taaaatctta tagttatagt
    34681 gtatcataag gttataaaat atagataaat atagtataaa tttaaaatat gtacagacaa
    34741 aacaaaaaaa tcatattcta agtaatactt gggaaaaatg atattatcat aataaataat
    34801 ctttgtaaaa acttatatag aatctattaa acagacacta agccataaaa actttactaa
    34861 atataaaatt cgtatctaaa tagatatata gaataatatt ttactgaagt agagtgattt
    34921 ttaagaattt tatatataaa ttatgttatc ataaataaag atatagatta taaaatttgt
    34981 taataaaata aagggcaggg aggtaagttt catgttttcc aaaatcctag tcaaaacatt
    35041 tatcagagat agcgaaaacg ttcaaaatac agatgttaga aataagtatg gttatgtagc
    35101 tggtgtagta ggtatattat ccaatttact tttatttgtg ataaaggtat tcataggaat
    35161 gctcacatct agtatagcta taatggctga tgcatttaat aatctttctg atatggcatc
    35221 ttcagcaata actatgatag gttttaaatt agcaagtaag ccagctgata aagaacaccc
    35281 ttttggtcat ggaagaatag agtatttatc agcattaata gtagcattta tggtgatgtt
    35341 ggttggactt caatttgtaa agtcatctat agaaaggata gtaaatccaa ttcctgtaaa
    35401 atttgaagta ataccactta tacttttaat tgcatctata atgattaaaa tctggttgag
    35461 tcgttttaat aaatttatgg gaaataaaat tgattcttca gccttaaaag cagtttcact
    35521 tgatgcttta ggagatgtat ttacttcaag ttgtgtagtt atatcattta ttgtagctag
    35581 atttactaat tttcccatag atggatatgt tggtatcgta gtatcattag tgatacttta
    35641 tgctggtttc tctcttgtaa aagatactat aaatcctctt ttaggggaag caccggatga
    35701 agaaatggta aattctatta tagagctatt gttatcttat aaatatataa taggtacaca
    35761 tgatttaatt attcataact atggagttgg tagatgtatt gcatctatac atgcagaaat
    35821 tccatccaac atagatataa tggaaataca tgaaattata gatactgcag agagagaaat
    35881 atctgaaaaa ttagatatat atctagtaat tcacatggac ccaatatgtc ttgaagataa
    35941 agaagttatg tcagccaaaa aagaacttga agaaatactt aagaaaaata gtcttgtaaa
    36001 atctatgcat gattttagaa tagttggaaa aggaagcaag aagaatttaa tatttgatat
    36061 agtagttaat ccttccgaat tttccaaaaa catgtcagaa gatgacttaa aagaagatat
    36121 aacaaaatta gttaaggaga taaatcctga atataattgt gtaattgttg tagataagga
    36181 ttttatttaa ttattaatta atctcatcat aaggtaaaaa atgtaaaaag gatagacaat
    36241 agtatagagg cataatataa tagaagtata taattgtatt tttaatataa ataaagcaat
    36301 tttaattgtt tttatgaaat attatagaga tgttgaagta tattctatta ttgggcacct
    36361 tatggatata ctgagtcagt ggtgcaaccg gctatgaata taaatttatt tattttcata
    36421 gctttttttg tataattttt tagtaaaaat tactttatat acgatattaa tggaagatta
    36481 gattataaat tataggtaac ctaaaggggt gagatttaca tgaagaaagg aaatagaaag
    36541 gcattattaa ttagtttaat tatgatttta agtatggtgg tgtctacaat atatccaact
    36601 gtatcttatg cttcggaatt aggagagaat agtcagattc aaagtggttc aactaattca
    36661 tcaactggag aggagaagga aagcgacaat aaaaagccag aacagactcc agagaaagat
    36721 aaggcaacag ataataaaaa accagaacag accccagagg aagaaaaacc aacagataat
    36781 aaaaaaccag aacagacccc agaagaagat aagtcaacag ataataaaaa gccagagcaa
    36841 actccagaag gagaaaagcc aatagataat aaaaagccag agcagatacc agaagaagat
    36901 aagtcaacag ataataaaaa gtcagaacaa gctttagaag atgaaaaacc actagacaat
    36961 aaaaatacag aaaaaactcc agaggaagat aatctattag aaaatgaaaa tttattgaaa
    37021 gttttagaag aagaacttaa tgaagaaaat gaagactatg gatttgttgt aaaaattaat
    37081 aacaatacaa tagaaacgga atcaatgaaa aaaatatcat ttaatttaac ttatactcca
    37141 acatcaaaag gaatacaagc aggagattca ataactttta aggtgccaga tgtattcaat
    37201 aaagttaatt tagattatac aagtgaatgc tttgataaaa cagaaagtaa tggagagtat
    37261 acacttacat ttagagaatt acctaatggc caaagtgtaa tgcaaggtaa aataggtttg
    37321 gaagcatatg ttaaaaaggt tgatgaagat actaatgcaa aaatacatat tgaaactact
    37381 ggaaaaatag aaagtggaag tggagatata gatgtagaaa taaaacctgg agataaaacg
    37441 gatgttccag atgctaaagg aacacttaaa aagcttgttg aaggaaaaaa atcaactact
    37501 gtatttatgc cagttaaaaa taaagatata aattacagta tacaagtaaa tgaaaagcag
    37561 gaagagttaa aagatattat tttgtatgat gagcttcctg aaggattgac attgataaat
    37621 ggttctgtaa gtgtagtaac aagtgatgga aaagaagtta gtgattttaa tattgaacag
    37681 agtaaaaatt ctatttcagt taatcttgga aatatagata aatcgtatac tgttaagtat
    37741 aaggctagaa tcagtgacaa aaatgcaaaa catggtaata aatataagaa tgtagctagg
    37801 attgaatctg atggtaagaa gatacaagaa gatgatgcta ctgtaagtat atttgataga
    37861 ggagatgatt atcttcttac taaaggacat tcaggagcaa caaatattac tcaagttggt
    37921 caagtaataa actatcagat ttcaataaat gatgataaat caccaataag taatgttgtt
    37981 ataacagata atataccaga aggcatgaga ttaactactt caggagaagc tgggcatgat
    38041 tttagagttg tagaaattcc aatgaatggg agctggactc cttggagtaa agaaaaaatt
    38101 gccaataata tttcatataa agtagaagaa aaaagaaatg aaagtgggca agtagataaa
    38161 gttataactg gatttacaat taatctcagt aaagaagaag tggaatcaaa gttttttata
    38221 gcttatacat taaaggtaat tagtattgaa gatagctata taaatagagc tgttcttgat
    38281 gcaaataata gtgaaattga taaaaatgat gagataaact ttaagaaaaa ttctggatta
    38341 ataagcgcaa aaaaagaagt tgataaaaaa gttttaaata gtagtgataa ccagattgtt
    38401 aaatacaaaa tcaatatgtc aacttatggg gtttatgatg caggacaagt aaatctttta
    38461 gatgaagtaa actcagctct agaaatatct aatataaaat attctgataa tcttgaactt
    38521 aaaaaagaag ctggagatgg aaaaaataca ataagattag taaataaata cgaatttaaa
    38581 cagataaaag aaggggaacc tgtgcaaagt tgggttacat ttgatgcaga cttcacaaat
    38641 gtaaaagttg gggagactat acgaaatgtg gctcagatta atggttcaag tcctccagga
    38701 gtagagacta ctaagcaagg ttatgctttt gaagctaaaa aagtggatgc tttagataaa
    38761 aatgtacttt caggtgctaa gttcaattta gaagatgcat ttggaaatat agtagttaag
    38821 gatttagtta gtgatgaaga tggtataatt caatctagta taaaaaaacc aggaacatat
    38881 tatttagtgg agataatggc tccaagtgga tatgaaaaac tgaaggataa aattaaggtt
    38941 gaaattggta ataaagatat tggtagaata gtggatattg gaaatataga aaacataaga
    39001 caagaaaatc caccagtaaa tccaccagca ccaccaaata cagatgaacc aatagtaaat
    39061 ccaccagtac caccaagcac agataaacca aggaaaccat caagttcatc tgatacagag
    39121 gatactatag ttataaatcc accaatacca ccatcagaag atataataaa tccgccaata
    39181 ccagaggtat tgaatccgcc agtaccacca tcagaagaga tgatagaaac tcctgttaaa
    39241 cagattattc caataccaga agtagtaaag ccatcagtgt cagaagaaaa aaataataaa
    39301 gttaaagatg atactttggt aaatccacca gtaccaccaa aaacagggga tagtactaca
    39361 attattggag aaatactttt ggttatagga gctattgtag gacttatcgt attaagaaga
    39421 aataaaaata caaattagac cctaacatta taaaaaatat aagttatatt aaaaaatatc
    39481 ttctaaaaca atatttaata atgaaaatat tgttagaaga tatttttttt tgaagattta
    39541 tgtaaaaaaa taataacttt ttagaaaaaa gttccaaagg gatatagaca attaaaaaga
    39601 tataagctat aatatagata taaaattaaa tgaggcaaaa ctagggaaac ctagtcacgc
    39661 aaagctatag gggctaaagt ttagtaaacc atgccagcca gttgccgaaa agagtaaaaa
    39721 tttctttttg tatatacaaa gatactcttg ggtatctttt ttattttgaa atttattact
    39781 cccggcctaa ctcaaaggag ggaataatat gagaccaagt aaaaaattat taatagctat
    39841 aatatcaata ttcttaataa gttcagttcc agtaagtgca catgcagata gtactactat
    39901 acaacaaaat aaagacacac ttagtcaaat agtagttttt ccaactggaa attacgataa
    39961 aaacgaagct aatgctatgg taaatagatt agctaatata gatggaaagt atttaaatgc
    40021 attaaagcaa aataacttaa aaataaaatt attaagtgga aagttaacag atgaaaaaga
    40081 atatgcttat ttaaaaggtg tagttcctaa gggatgggaa ggtactggaa aaacttggga
    40141 tgatgttcca ggtttaggtg gaagtacagt agctcttaga ataggattta gtaacaaagg
    40201 taaagggcat gatgcaataa atttagaatt acatgaaaca gcacatgcaa tagaccatat
    40261 agtattaaat gatatatcta aatcagcaca attcaaacaa atatttgcta aagaaggtcg
    40321 ttctttaggt aatgtaaact acttaggtgt atatccagaa gaattttttg cagaatcatt
    40381 tgcatattac tatttaaatc aagatacaaa tagtaagtta aaatcagctt gtccacaaac
    40441 ttatagcttt ttgcaaaatt tagctaaata gagttttaat aaatttaaaa taaatataaa
    40501 taaagagatg ctattataat agcatctctt ttatattgcg tttaaatcta ataaattttg
    40561 tcttatgtat aactatgata gattatcaat tactactcct tatacaaggc ttcaacgtgt
    40621 ttattatgca tttgagtaat tatcgtaggt ataatagaaa ttattgaacc aattactatc
    40681 aataaaattc ctataaccat gtttataggg ataatttctt taagtattaa taatgctagt
    40741 attggagata ttactggttt aaagaagaat actaaagatg taagactagt agatgtagct
    40801 tccattgcca taaagtaaag cgcataacca acacctgtaa caaatacgaa tacataaatc
    40861 ataatgggca tattgtgtaa ggtatatcca ctaaaaatag ggatatttgc aaatacatga
    40921 agcttatttt tatttaatat atctgcgata aaattaattt tagtgagtaa aaccaatatc
    40981 aacatttcca aactaccaaa tataaagcta aagcaggtta caactattcc accaaatttt
    41041 aaggtttttc ttttaccaaa tacagtatac attgaaaaaa taatagcaga agataatgtt
    41101 aagaatattc cactaagagt tagttttgta tgcaatggat ttattataac tataattcca
    41161 agaacttcta atataagtga aattacattg tgcctatata ttttttcctt caaaattaag
    41221 taagctaaaa gcattacaaa gactggatta caactgaaca aaacagcaac tacagatgcc
    41281 tttgtgttta gaacagcaag ttgatacaat gacatactta ctactacaca cataaaacct
    41341 aaaaatgcaa agtattttaa gtctgatttt gtaatagaaa gactaagagc tcttaatctt
    41401 tttacagcaa aaggtagtaa gactaaaccg ccaacaaaaa atcttgataa agttatttgt
    41461 aagggattaa agtcattagt gacagttttt agactaattt ccattgaact aaaaaataag
    41521 gtagtcagta ttatataaac ataacctttt ttcaagtcaa acacctcctt gtaatttata
    41581 ttagtactat agataagaat attcaagcat attggaataa tatggtatgt ataaaatata
    41641 gtacataaaa ttataaacta ccttaatata gaatgtaagt attctatact aaggtagtta
    41701 attatttgaa ttactttgat ttagttattt taaattatat aatttggcta atttttcaaa
    41761 tgctggtaaa gaacttttaa ctttatcata agatacacaa tatgatactc taaaatgacc
    41821 tggacaacca aaagaagaac ctggtactaa taataaatta aattgttttg catcattgca
    41881 gaatttttta tcatcttcaa ttggagcttt tgggaacaaa tagaatgtac cattaggttt
    41941 aacacaagaa tatcccatat cgattaaact attatataga aggtcaaaat tctttttata
    42001 aatatttaca tcaacttctg catctaaact tcttgcaata accctttgaa aaagagaagg
    42061 agcatttaca aatccaagta ttctatttgc aacatttaat gaagacataa catcatcaaa
    42121 atcatccatt tgcccattag caacaatata tcctatacgt tcaccaggta gagataatga
    42181 tttactataa gagtatccta taaatgaatt tctatagtat tttagtacac aaggaacttt
    42241 ggcaccatca taaattattt ctctatatgg ctcatcagaa attaggtata tgcttgtatt
    42301 aaattctttt tgttttgaat ccaataattc tccaagattt tttaataatt cttcagaata
    42361 tatgacacca gtaggattat ttggagtgtt tattattaaa gctcttgttt ttggagtaat
    42421 agcatttttt agagcatcta aatctggttc aaaagtctct atatttgtag gaacttctat
    42481 taattttcca tcatagtttt ctgtataatt tttatactca ccaaaatacg gtgcaaaagc
    42541 aataacttca tcaccaggat ttaaaagagt ttttaaaata atatttagac caccagcagc
    42601 accacaagtc ataattaaat tttctcttgt aagatttaat ccatcttttt tatttatgtg
    42661 ttcagcaata gcatctctta catcctcata tcctgagttg ttcatatatc catgaactaa
    42721 atttggagat tcttcattta aaatatcatt tataactgct ttaatagtct ctggaggttc
    42781 aacacttgga tttcctatac taaaatcaaa aacattttcc tcaccataaa tatcagaaag
    42841 tttctttcct tcttcaaaca tagctcttat aacagaacta tttgcaacta aagtttgcat
    42901 tttattagat atcatatgta acactccttt ttatagattt atattgctta tgtatatatt
    42961 accatatttt tactgaattt agacaatttt cgaaaaatta cttgtttgaa aatataaact
    43021 tttatataaa atatatttat gtacagt
//
LOCUS       DAEHWM010000028        41907 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.029, whole genome shotgun sequence.
ACCESSION   DAEHWM010000028 DAEHWM010000000
VERSION     DAEHWM010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 41907)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 41907)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..41907
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.029"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            93..1007
                     /gene="murB"
                     /locus_tag="KNP36_001541"
     CDS             93..1007
                     /gene="murB"
                     /locus_tag="KNP36_001541"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HBF0873419.1"
                     /translation="MNNQDIYINLLNILSKEDIKVDEPMKKHISFRVGGPADILVRPR
                     TEEQLKNVLKLVKKESIPYLIIGNGSNILIKDGGIRGVVIELADNFNSYEINDTRMTA
                     QSGALLSVLGKALQKQELKGFEFASGIPGTLGGALAMNAGAYGGEMKDIVKSVRLMDM
                     EGNIFELSNEQMEFGYRKSIISKNGYIALSAELELQEGNYDEIKSLMDDLATRRITKQ
                     PLNFASAGSTFKRPTGYFAGKLIEETGLRGLTLRGAQVSEKHCGFVVNQGEASAKDIL
                     DLIYVIKSAVYAKFGVMLEEEVKILGED"
     gene            1011..1724
                     /locus_tag="KNP36_001542"
     CDS             1011..1724
                     /locus_tag="KNP36_001542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBF0873420.1"
                     /translation="MKILADYHTHTLYSHGKGTIEDNVKVAISKGIKTIGISDHSYKH
                     IAYGVKKKDILKMREEVDYLNDKYTDINILLGMECNILDDKGNIDMDDKFIRDFDYIM
                     AGYHFGSTPTSLRSLLNHCNNYIFKTEKAKEYNTKAVINAISNNDIFIITHPGDKGDV
                     YIEEVAKTAKKTNTRLEINSSHSFLNVNQLNKIKGLENKFIIGSDAHCPERVGDFELA
                     MKTISDSNLDISLVENIII"
     gene            1755..2612
                     /gene="rapZ"
                     /locus_tag="KNP36_001543"
     CDS             1755..2612
                     /gene="rapZ"
                     /locus_tag="KNP36_001543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HBF0873421.1"
                     /translation="MKFVIVTGLSGSGKSETMRALEDMGFYCVDNLPPALITKFAELC
                     YQPNSSIDKVALGIDIRGRKFFEALHESLNYLEKENYEYEMVYLDCNDDVLLKRYKMT
                     RRNHPLAKDMQIPEGIKMERKIMEPLKELSTCIIDTTNMKPKDLKEEIKKIYSSGEDN
                     PNLTISVVSFGFKHGILADADLVFDVRFLPNPYYVEELRAKTGDDKEVRDYVMNSKIS
                     EEFYVKLLDMIHFLVPQYIEEGKQHLVIGVGCTGGRHRSVTITNLIAEDLSNKGYRVV
                     KKHRDSMLR"
     gene            2624..3730
                     /locus_tag="KNP36_001544"
     CDS             2624..3730
                     /locus_tag="KNP36_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HBF0873422.1"
                     /translation="MAKLLIIVGILGWIALIVSLFIYKKAKNEKVKLFQRSIVENREP
                     NVVVIGGGTGQSVFLRGLKHTTQNITAIVTVADDGGGSGVLREDLGMLPPGDIRNCLL
                     ALANIEPTMNEVMQYRFTEGLLKGQSFGNLFLAAMNGLYGNFEKAVYKLSEIFAITGR
                     VLPVTLEDVNLVAKLENGNIINGESSIPEESKIQKSSIDKIFLNPKDVKPLKDVIASI
                     YDADIIIMGPGSLYTSIIPNLLVEGIVDAIKSSVAPKVYIANIMTQPGETEGYNVLEH
                     VNAIVKHTDENLIDYVIANNEILPEEMLDLYKQDGAEQVLLDKKQKDKLKEMGIKTVE
                     KNLIEIKNNYIRHDAKYISNIVIELALNHNYNKS"
     gene            3799..4224
                     /locus_tag="KNP36_001545"
     CDS             3799..4224
                     /locus_tag="KNP36_001545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBF0873423.1"
                     /translation="MREEVSAGGVVLFGNTILLLRKFNGDWVLPKGKVEEGENNQEAA
                     LREVSEETGVKADILKYLGEIHYTFKENWDENRAVHKTVFWYLMQAKNMDTIPQKEEG
                     FIDAKFIHLDRVVDLARYDDEKEIIKVALQEIKKRLKKN"
     gene            4241..5188
                     /gene="whiA"
                     /locus_tag="KNP36_001546"
     CDS             4241..5188
                     /gene="whiA"
                     /locus_tag="KNP36_001546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HBF0873424.1"
                     /translation="MSFSTETKNELARVISGNECCNIAELSALVKSGGSIQIVGYKKL
                     NLKITTELNSIARKVFKLLKKNFNINTTISVNKNQMLKRNNSYVLMVTSEMGSEMLLK
                     KLGILEDKEGFFTINKISENLIKHEGCKRAFIRGAFLGGGSISDPEKNYHMEFVTNNE
                     EFADSLKELINSLGFNSKIVARKNNHVVYIKESEQISDLLSIIGGHHALLSLQNTKIV
                     KEMRNNVNRIVNCETANLSKTVNAAVRQVENIKLIQETIGISSLPENLQEIAKIRIEY
                     EDMTLKELGEMLEPPIGKSGVNHRLRKIEEIATDLKKKS"
     gene            5345..8914
                     /locus_tag="KNP36_001547"
     CDS             5345..8914
                     /locus_tag="KNP36_001547"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HBF0873425.1"
                     /translation="MNKDFAHLHVHTEYSLLDGFSRVKKLIKRAKELNMSSIAITDHG
                     CMFGVIDFYKTAIKEGIKPIIGCEVYTAARGLRDKDPNYDKYQGHLVLLAKNMEGYKN
                     LIKIVSTSYVEGFYYKPRVDMEELKKHNKGIIALSACLAGDVARALMNRNYEKAKQFA
                     LDYRDIFGEENFFLEIQDHNLPEQKEVNSGLVKLSKETGIPLVATNDVHYVNKEDSKI
                     HDVLMCIQMGKTLNDPNRMRFGSDEFYLKSREEMEELFPYALEAIDNTVKIADMCNVE
                     FDFNTIHLPKYDVPEGYTPETYLRELCFNGLKERYDNPSNEILERLNYELDVIEKMGY
                     VEYFLIVWDFINFSKENNIIVGPGRGSAAGSIVAYTLKITDIDPIKYSLLFERFLNPE
                     RISMPDIDIDFCYERREEVIDYVKRKYGDDHVAQIITFGTMGAKAAIRDVGRVLDIGY
                     NKVDKVAKEIPFALGMTIDKALDTNPNLKELYDQDPETKEIINISKQIEGMLRHASTH
                     AAGVVISKNPVDEYVPLYKHQDAITTQFTMTTLEELGLLKMDFLGLRTLTVIRDTLDL
                     IEKNRVIKNYTEKIDFSKMDYDDPKVYEMLSSGNTLGVFQLESAGMRSFMKQLKPDNF
                     EDIVAGISLFRPGPMDSIPAYIKNKSNPKDVTYLHEKLKPIMEVTYGCLVYQEQVMQV
                     VRDLGGYSYGRSDLVRRAMSKKKMDVMEEERQYFIHGKFDEDGNIEIAGCIRNGVEEE
                     IANKIFDDMIDFARYAFNKSHAAAYGVLAYETAYLKTYYPVEFMAALITSVMGNTDKV
                     VEYIRECKALEIDVLPPDINKSFSKFSVEGDNIRFGLAAVKNVGVNIINNIIAERESN
                     GLFVDLVDLVKRLDQKDTNKRVIESLIKCGAFDNISENRASLMAGYESLLESVSMDRK
                     KNVQGQISLFDAFGDSEEDSDFQQIYSLPKRQEYEERERLNLEKEVLGMYVSGHPLSQ
                     FEKELQEKTSMDNGKLNSLKEEEESYLQMNETDVIMGGMIVTKTIKTTKRNEIMAFIE
                     LEDLYGAIEIIVFPQLLQKYNVILNEDNIIYVKGTLSIKEGENAKLIAREIKDINDDT
                     DFADRNYNSGRTRNVENIKPESGKKLYLKIDSMSDTDTTNNIVEIAKQYPGNDSIYLY
                     PMDENINGKRKAYKMTGALTCICDEFINNLEELLPKDNIKVKA"
     gene            9123..10082
                     /gene="pfkA"
                     /locus_tag="KNP36_001548"
     CDS             9123..10082
                     /gene="pfkA"
                     /locus_tag="KNP36_001548"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HBF0873426.1"
                     /translation="MKTIGLLTSGGDAPGMNAAIRAVVRSAIYYGCKVYGINRGYKGL
                     LEEDLTEMNLSSVGDIIHRGGTILKSSRCEEFKTEEGRLKAVKILKKYKIDCLVVIGG
                     DGSFAGAQKLSDLGFPAIGIPGTIDNDLAYTDYTIGFDTAMNTIIDAIGKIRDTSSSH
                     ERVNIVEVMGRHCGDLALYAGLAGGAETIIVPEVEITVDEVALRLKTTQKRGKRHSII
                     VLAEGVGSASDLEKELKKESGADLRVTVLGHVQRGGSPTVSDRILASRLGVRAVELLL
                     DGKSARVVGIKENKIIDLEISEALAQKKVFDKEAYEMAKILSI"
     gene            10134..11894
                     /gene="pyk"
                     /locus_tag="KNP36_001549"
     CDS             10134..11894
                     /gene="pyk"
                     /locus_tag="KNP36_001549"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HBF0873427.1"
                     /translation="MLNNVKKTKIVCTLGPASQSEEVLTQLMQNGLNVCRFNFSHGSH
                     EEHKERIDMAKKVREKLNKPVAILLDTKGPEIRTGNFEDPEVFLEEGQKFTITMKDIM
                     GTKEMCTVSYKGLAEDVKSGDSILIDDGLVGLRVKEINGEDIVCVVENSGIVKNHKGV
                     NVPGVKINLPAITPKDISDIEFGISQGIDYIAASFVRKASDVLAIREVLENNNATDIQ
                     IISKIENQEGVENLDEILKVSDGIMVARGDLGVEIPTEEMPIVQKMMIKKCNELAKPV
                     VTATQMLDSMIRNPRPTRAEVTDVANAIYDGTDAIMLSGETAAGKYPVEAVKMMATIA
                     KRTEETLDYDRLLKENGTNNVTVTDAISHATCTTAVDLNASAIITSTSSGYTARMVSK
                     FRPKSPIIATTNNEKTMNKLALTWGVYPVKSSVAGNTDEVIEKAIEAARQADYIDNGE
                     LVVITAGVPVGVSGTTNLIKVHVISEEIVQGIGVGTQTVEGKVRIIKNGNACVDFNEG
                     DILVSTATDAEMNNYIEKAGAVVTENGGMTSHTAIVGINLDIPVIVSAADITNLVKDG
                     EVVTVDASRGVVYRGSTRVL"
     gene            12069..13427
                     /gene="rlmD"
                     /locus_tag="KNP36_001550"
     CDS             12069..13427
                     /gene="rlmD"
                     /locus_tag="KNP36_001550"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HBF0873428.1"
                     /translation="MLSKNEMYIVDIVDIGQGGVGVGKYNGITVFVEGGLIHDKVKVR
                     INKVKKNYAVGDIVEIIEKSPFRVKRVCSDNLRDCGGCQIQDLDYNKQLEMKTNEVKQ
                     VLSRIGKLEDVEVHDTIGMDNPYRYRNKAQFPIQKNNGIPIIGFYKKKTHDVISTEKC
                     VIQHEINDKIVKIIKTYIRAYKVSIYDEKTHTGLIRHLVTKIGFTTKEVMVVLVANGN
                     KLPYLKELASVLKENIPGFKTLVVNVNQKDTNAILGRENIVIYGDGKINDYIGDLVFE
                     ISPLSFFQVNPVQTKVLYDKALEYANLNDTDTVFDIYCGIGTISLFLAQKAKKVYGIE
                     IIDDAIKDAKINAKLNNIHNAEFYVGKAEEIVPKMYREGKTANVVVVDPPRKGCDEKV
                     LETIVSMNPERIVYVSCNPSTLARDLDYLNVHGFKCVEAQPVDMFPHSTHVETVAKII
                     KQ"
     gene            complement(13900..14538)
                     /locus_tag="KNP36_001551"
     CDS             complement(13900..14538)
                     /locus_tag="KNP36_001551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873429.1"
                     /translation="MSNQRKDFDITNDMFQESIPITTKIILEDMPSNDELNHVFSKGC
                     ERKMKKRKIVLITLLLIGVLLLGSILYNLFLGKTANISMLKESWNFDIPIPNKEIEVF
                     DTQDSINGDGQSYFIQGFSEKNFKKVFNLKGGIVVSKDNINEIEKYIDKFKRDSVNIN
                     KSNKNKIEEDFKKYKLEVKKDDKYIYKRNYENYVVLIIKKDEQKLYSLIWNQ"
     gene            complement(14948..15124)
                     /locus_tag="KNP36_001552"
     CDS             complement(14948..15124)
                     /locus_tag="KNP36_001552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873430.1"
                     /translation="MFRDKMDRCTHMLTAYIGSSYDYCDFIDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     regulatory      complement(15178..15274)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            16071..16472
                     /locus_tag="KNP36_001553"
     CDS             16071..16472
                     /locus_tag="KNP36_001553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNHCP domain-containing protein"
                     /protein_id="HBF0873431.1"
                     /translation="MNYKNRKRAYYQENSCMDNFICKNCGCLVVPEGAGTQHRNHCPH
                     CLHSLHVDIIPGDRAADCDANMEPIGVWVRKNGEWAIIHRCTRCGHLSSNRIAADDNS
                     VKLMSIALKPLAQPPFPLERIIEKLEKEETE"
     gene            16469..17536
                     /gene="rsgA"
                     /locus_tag="KNP36_001554"
     CDS             16469..17536
                     /gene="rsgA"
                     /locus_tag="KNP36_001554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HBF0873432.1"
                     /translation="MNGMKQINLQDYGLNRNFITQSMEYHDLYLARIISQEKNFYQAV
                     CVNGVLFAEVSGKLRFEATIQSDFPTVGDFVMLDRCNNKNGNAIIHHVLHRKSLFVRK
                     AAGKVNEEQVVAANIDIVFLCMSLNKDFNIHRLERYLSLTWESGAIPVVVLTKSDLCD
                     NVHRKLQVVNSIALGVDVVVTSSIEPDGYKQISKYIKPGCTVALLGSSGVGKSSLINC
                     LMGGEFLNTKEIRIDDDKGRHATTRRELFLISGGGIVIDTPGMRELGMWDVSEGLDKS
                     FADIEAYFGKCHFRNCTHTSEPGCAIWEAIAHQELSPKRWESYRRLKTEAVFADNKSE
                     YLAKKEKKFKNISKINKKIRR"
     gene            18072..18770
                     /locus_tag="KNP36_001555"
     CDS             18072..18770
                     /locus_tag="KNP36_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873433.1"
                     /translation="MKISSQYRSQYSFRYESNINNTRINESMVKKNETVGKDTYLSNI
                     MKQKQELNDRIRDLKYRQEVYTKKINDAIKNLCKSEIRETTNNFSNIEIGIKNSIIEE
                     KNKSTMLDENSTYLNTNDEKESLITKESNEKIEEEILNDEKLEELEQKKDYKEDSNKK
                     EKVSEDLSLVGKTREELENMLKNFINLTQEEIMKLESRIEKLDKNAEEYKQNSKTNIF
                     DKTDEQKKHINVLI"
     gene            18948..19838
                     /locus_tag="KNP36_001556"
     CDS             18948..19838
                     /locus_tag="KNP36_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873434.1"
                     /translation="MKKNILTTMITMIIILMMSMTVMAEPYQEDETSSLKKQSANERN
                     QTNIGTMDGRVQTNAISKGANYDPKYPLKGMLTQLGLNTTGKEGWDLLYGGNPNGVEL
                     RADGKYYYINKGMEGLGFYAAALSGGSYQRIGFGKLDPIEVIADGNWISYKQAQDTLT
                     VIRNFLNSFDWRNASEMERANRAAKLVTEAKYADSKYCNIVYGNLVDKRGVCGSFASS
                     FHLLTRLMGMDSLSILNPSLNHAWNYIQIDGKWYRFDGSEISAFGGSLDFDYRKLKDA
                     TREMTTYYDAKALSILGFNQ"
     gene            complement(20231..21187)
                     /locus_tag="KNP36_001557"
     CDS             complement(20231..21187)
                     /locus_tag="KNP36_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0873435.1"
                     /translation="MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALI
                     GTGKHEFYETLEEFIIGLEKDQTESEQIDFEIIDEWYSCTKVTDEAFIVYGTLWVIEK
                     DYLEKDIYVEMDTRFTMVYRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEAL
                     AMANEFKLKSEKDLMTGLYNRHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHV
                     RGDEILIHFSNILTKVFVNDAIIGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLES
                     NSCSIGISKLENNSDTFQSLYKQSDYALYYSKRNNKGNFSWF"
     gene            21890..22885
                     /locus_tag="KNP36_001558"
     CDS             21890..22885
                     /locus_tag="KNP36_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0873436.1"
                     /translation="MSIIELNELTKAYRRFEKKAGFMGSVKSLFNRKYTEKTAILSFD
                     LKIEEGEFVGLIGQNGAGKTTLIKMLTGIIAPSSGEISVMGYYPNKLENNFKKQYAVV
                     MGQKSQLFFELTPADTFLLFKELYDISNEEYKKNLDYFIELFEVSDYLNVQVRTLSLG
                     ERMKMELIVALLHNPKILFLDEPTIGLDAIAQKQIRYFLKEVNETKGTTIILTSHYME
                     DIKSLCSRSIVVENSRKIYDGSTEKLFNHFQKYKKITVSFSNETNIVFPKDCKVVEQT
                     NHKISVIVPKERGNETIKWIFDKYDVKDVMIEEEDIGSIVERIYKKGSDEYYEQL"
     gene            22863..23726
                     /locus_tag="KNP36_001559"
     CDS             22863..23726
                     /locus_tag="KNP36_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HBF0873437.1"
                     /translation="MSIMSNYNEASSNDSMFYKFKQSIRRYYEVAKINFKVQLIWRFD
                     VVVNMVFTIVKILFAYILWKAIFGENKIVSGFTFNSMLSYYIISSFLAGIDMSKSTSE
                     EICNRVKLGTFSKYMIIPINVQNYFIAKNFGMTCFYFVFNMISAFVWIFIFKIDFAFT
                     SNPVQILISILMIFLGFIFMMKLHFFIGILSFKFLEISFFKMIIENIVEFITGTMIPL
                     VLLPETIVTVMKVFPFYYTTYLPSMLLIGRNSNEAIQGLIILALWVLFFSVVNKVMYK
                     RMRTLFDGVGI"
     gene            23723..24517
                     /locus_tag="KNP36_001560"
     CDS             23723..24517
                     /locus_tag="KNP36_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HBF0873438.1"
                     /translation="MMKKNLKIIFMLLKMKLSKMMVFRFDFFGAFFVDSSLFILQLLM
                     FNSIYSHVDSIGGWQQGEMLIFIGTFSLINAINMTIFFFGIYDIPRKIQEGELDYYIT
                     KPLDPLFRLTFENINIGSSPLILASILIVLYGISELNSEITLVMIIIYIFMVLLMTLL
                     FYDVCIILRTVSFFVISSSAIMRLEDNLLPMNMKIPGVIYEGVFKVLFYLILPYGIMS
                     TIPTQILAGTITINGLIYSILIVFLFTLFMWRFWKLGMRHYKSASS"
     gene            24802..26181
                     /locus_tag="KNP36_001561"
     CDS             24802..26181
                     /locus_tag="KNP36_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0873439.1"
                     /translation="MSDVYYSENHEQDNLYEQDNLLAQRFNLFTLLKFAFPTIFMMIF
                     MGLYTIVDTIFVSRFINTNALSAINIVCPIINLIVGIGTMLATGGSAIVARKMGNGDI
                     EGANKAFSLIVLSGVVIGVIITGIGIVFMDYIIIWLGASEVLIKYCRSYLFIILVFAS
                     ANILQVLFQCLFVTAGKPQFGLWLVLGAGCANIILDYVFIVLLQMGISGAALATGVGY
                     LIPTVSGMVFFSKNKGLLKFCIPRLDKRILFEACFNGSSEMVGQLSTAVTTFLFNAMM
                     MKLIGEDGVAAITIIIYSQFLLTSLYIGFSMGVAPIISYNYGSENNTQLNHVFKICIL
                     FISVASLLVFIFSISCSPIIVEIFSQRGSRVYEIARSGFYIFSFSFIFCGYNIFTSSM
                     FTALSNGKVSAILSFLRTFGFITIGLLILPNILNINGIWLAVPSAEILTLFLTIFCIC
                     KYKNRYKYM"
     gene            26629..27342
                     /locus_tag="KNP36_001562"
     CDS             26629..27342
                     /locus_tag="KNP36_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873440.1"
                     /translation="MDTCFNKKILLVDDEKDIVDLIEEVLINDGFKNIIKAYNGLDAI
                     SLCKIACPDVVILDIMLPDIDGIEVCKKIREFSYCSILFLSSKNDDIDKILGLSSGGD
                     DYITKPFSPREIAFRVKAQLRRQQYQSIVPSDSEVIKIGDITIDIEGNRVYKDRNEIE
                     LTGREYHLLSYMAQNVNKIIGKERLYEQVWGVYSSICDNTIMVHIRHIREKIEDNPSN
                     PKILITVKGLGYKLVNRID"
     gene            complement(27614..29152)
                     /locus_tag="KNP36_001563"
     CDS             complement(27614..29152)
                     /locus_tag="KNP36_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBF0873441.1"
                     /translation="MSLLKVTNLSQCFMDKSLYEKANFDLFKGEHIGVVGQNGTGKST
                     LIKILLGEVVPDSGEIKWQPNINIGHLDQYAEINRDTTISLYLHTAFEELYKIEKEMN
                     LLYQKSAISENEQYLIKASDYQEQLIASNFYSIDNEINKIANGLGLDSIGMNRVVGEL
                     SGGQRAKVILAKLLLSNHDVLLLDEPTNFLDKEHVEWLSNYLNTFNGAFIVVSHDFDF
                     LEKISTGILDIEFGMIKKYHGKYSEFLKQKSHLREDYIRRYQAQQKKIEKEETFIRKN
                     KAGVNSKIARGRQKQLDKIERIAPPSFTGKPNIQFSEIEISAQNALTITNLEVGYYYS
                     LLPKLNFSVDGGQKIVITGFNGIGKSTLLKTLVKDIPRISGDFQFSEQVKIGYYEQDL
                     KWENPDKTPLQIVADKYPKLNTKEIRRHLARCGVKEEHVSRSVSTLSGGEQSKVKLCC
                     MMLSPCNFLILDEPTNHFDAETKDALQNALKQFRGSIILVSHEEKFYKGWIDKVFNIE
                     KQLV"
     gene            30034..30489
                     /locus_tag="KNP36_001564"
     CDS             30034..30489
                     /locus_tag="KNP36_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="HBF0873442.1"
                     /translation="MDEIDLKIINSLKKNSRASTSEISRQINLSVPAVSERIRKIEQS
                     NLIQKYTIQINREKTKYKLLAFIFINTDLSKSMKEFKKTILEYDTVLECHHISGEYDY
                     LIKVLAEDTSNLEEFISVTLKEIGGIQKANTTIVLSTIKEEFNTIKDIF"
     gene            30538..31122
                     /locus_tag="KNP36_001565"
     CDS             30538..31122
                     /locus_tag="KNP36_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1/PfpI family protein"
                     /protein_id="HBF0873443.1"
                     /translation="MKVLVFLAKGFETMEFSVFVDVMGWARNDYGHDIDVVTCGFKKQ
                     VMSTFNIQVLVDKTIEEVCVDDYDALAIPGGFEEFGFYDEAYDSSFLNLIREFNSKEK
                     IIASICVAALPVGKSGVLKNRKATTYHLKNGKRQRQLSEFDVNVVNEPIVVDKNIITS
                     YCPETAPHVAFKLLEMLTSKEQMDEVKLAMGFKL"
     gene            complement(31127..31450)
                     /locus_tag="KNP36_001566"
     CDS             complement(31127..31450)
                     /locus_tag="KNP36_001566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873444.1"
                     /translation="MKKCLDNYSCPIEATLALIGGKYKTLILWHLKDTILRFNELKKL
                     IPKATPKMLTQQLRELESDGLIIRVVYPVVPPKVEYSLSDFGKSIIPILDSMCDWGSD
                     YLENL"
     gene            31602..32120
                     /locus_tag="KNP36_001567"
     CDS             31602..32120
                     /locus_tag="KNP36_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0873445.1"
                     /translation="MNFVELAKKRYSCRNYQDRKVEKEKLEKVLDVARIAPTGGNRQP
                     QRLIVIQEKEGINKLSKAANIYDAPLAILVCGDKDKVWTRPFDGKQLTDIDTSIVTDH
                     MMLQATELGLASVWVCYFNPDIIREEFSLPDNLEPINILLMGYESKIPESPERHEKTR
                     VPLSEIVSYETL"
     gene            complement(32296..32964)
                     /locus_tag="KNP36_001568"
     CDS             complement(32296..32964)
                     /locus_tag="KNP36_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873446.1"
                     /translation="MLEISHKVKEIYPNIKFGVMVINITHSKPNKENFLVLKNSTIKN
                     IIEQHPEYNRKEKIKTEPVSSYIKYYKKFKKTYPVLLQLESILLKSKGIPDVGVTIES
                     MFLAELKNLLLTAGHDLDKMELPLKIELANGSEHFYGIGGKEHILTKDDLFLSDNIGI
                     LSSILNGPDNRTAITKDTKNIMYFVYGPDKISEKQIQDHLNDIKHYISSAFPDLKVNS
                     IDIF"
     gene            33079..34494
                     /locus_tag="KNP36_001569"
     CDS             33079..34494
                     /locus_tag="KNP36_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0873447.1"
                     /translation="MWITINRNSNISLSRQIYCEIKDMILDGSLKFEQKLPSSRTLSK
                     ELSVSRNTVLDAYNQLIAEGYLETRNGYGTIVAKGISGHKVDFKLNDTFRDEKDLHTN
                     KQKNYIDFRSGVPELKLFPRKELSKLYKQILYDLSDSDFRYGSTAGVWVLRVEISKYL
                     FRTRGIRCNPKNIMIVSGSTQGLSLISQLLYKSNKKVAVEDPIHKGLLKVISSIGYSV
                     VGIKVDDKGMNTNLIKSIKGISFVYTTPSHQYPLGGILPIQRRLELIKCATENDYYII
                     EDDYDSEFRYEGQPISSLYELSPNKVIYIGSFSKILSPAIRVGFMLLPDNILESYKTL
                     KMYSDVHTETILQHVLAEFIGNGGLEKYIFRMKKLYNRKRKYLIKVLNTEFKNEFKIK
                     GEAAGLHIVAHFYNVKFTESLIHKIFEAGIKVYPIQQYAIENILEYDYEIILGYAHLS
                     FDEIEKGVKILSKIIHMNQGT"
     gene            34717..35175
                     /locus_tag="KNP36_001570"
     CDS             34717..35175
                     /locus_tag="KNP36_001570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873448.1"
                     /translation="MEIIDYIEENLTENLNLDKIAYIANYSKYHLHRMFTNVVGCTIH
                     QYIQRRRLTEAARQLIFTDKYIIDIAITVGYSTHQSFTLAFRNLYKESPQVYRNKDEF
                     YPIQQRFVLNLNHQIQSEKCISYANMNYKQRRDEINSYLNFNINCEVKVA"
     gene            35172..35756
                     /gene="clpP"
                     /locus_tag="KNP36_001571"
     CDS             35172..35756
                     /gene="clpP"
                     /locus_tag="KNP36_001571"
                     /EC_number="3.4.21.92"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp endopeptidase proteolytic
                     subunit ClpP"
                     /protein_id="HBF0873449.1"
                     /translation="MSLVPHVIEQTGQGERSYDIYSKLLKDRIIFIGEEINDAIASLV
                     VAQLLFLESEDPDSDIIIYINSPGGSATSGFAIYDTMNYVRCDVSTICIGMAASMSAF
                     LLAGGTHGKRCALPNSEIMIHQPMGGAKGQATDVKIAVDNILKIKERLDKILSENTGK
                     SIEDIRRDTDRDNFMTALEAKEYGLIDYIMNRNE"
     gene            36068..37144
                     /locus_tag="KNP36_001572"
     CDS             36068..37144
                     /locus_tag="KNP36_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0873450.1"
                     /translation="MITISLCMIVKNEEEVIGRCLECVKDIVDEIIIVDTGSTDSTKE
                     IVSKYTDMVYDFEWIDDFSAARNFSFSKASKDYTMWLDADDIILEADREKLLKIKESL
                     DTSIDIVMAKYNVSFDENGNPTLSYYRERLFKRSSNHKWVDPIHEVVPLFGEVFYSDI
                     AISHKKLHRQDPLRNLRIFEKMISEGKTLEPRHQFYYSRELYYNARYKEAIEGFTKFL
                     DSSRGWIEDCISACRDLATCYYLINDEKSALYSLFRSFEFDEPRAEICCDIGKHMFDR
                     QKYKEAIFWYKVALTRDKNDTDGGFKSDDCYGYIPSIQLSVCYDRLGESDKAIYYHEK
                     TKEIKPNDSAVLHNENYFSKFKNS"
     gene            37211..39286
                     /gene="bclA3"
                     /locus_tag="KNP36_001573"
     CDS             37211..39286
                     /gene="bclA3"
                     /locus_tag="KNP36_001573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA3"
                     /protein_id="HBF0873451.1"
                     /translation="MLLIMSRNKYFGPFDDNDYNNGYDKYDDCNNGRDDYNSCDCHHC
                     CPPSCVGPTGPMGPRGRTGPTGPTGPTGPGVGATGPTGPTGPTGPTGNTGNTGATGLR
                     GPTGATGATGPTGATGAIGFGVTGPTGPTGATGATGADGVTGPTGPTGATGADGITGP
                     TGATGATGFGVTGPTGPTGATGVGVTGATGLIGPTGATGTPGATGPTGAVGATGIGIT
                     GPTGPTGATGADGATGVTGPTGATGATGADGVTGPTGATGATGFGVTGPTGPTGATGI
                     GITGATGLIGPTGATGATGATGPTGVTGATGAAGLIGPTGATGATGADGATGATGATG
                     ATGPTGADGLVGPTGATGATGADGLVGPTGPTGATGVGITGATGATGATGPTGADGLV
                     GPTGATGATGADGVAGPTGATGATGNTGADGATGPTGATGPTGADGLVGPTGATGATG
                     LAGATGATGPIGATGPTGADGATGATGATGPTGADGLVGPTGATGATGATGATGPTGA
                     TGATGATGPTGASAIIPFASGIPLSLTTIAGGLVGTPGFVGFGSSAPGLSIVGGVIDL
                     TNAAGTLTNFAFSMPRAGTITSISAYFSTTAALSLVGSTVTITATLYQSTAPNNSFTA
                     VPGATVTLAPPLTGILSVGSISSGIVTGLNIAATAETRFLLVFTATASGLSLVNTVAG
                     YASAGIAIN"
     gene            39455..40216
                     /locus_tag="KNP36_001574"
     CDS             39455..40216
                     /locus_tag="KNP36_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase"
                     /protein_id="HBF0873452.1"
                     /translation="MKNKIEISMNNFVKNYHKSNNITTKWQELLFAYASAEDDMFQKL
                     KSVVGTSHAMPKDFLENGKTIITYFIPFDESVNNSNIGGFECSEIWARAYIETNMLIS
                     NLNDFLCEELEKMGANSYAIPGSYNFDSEKLVSDWSQRHVAFIAGLGTFGLNNMLITE
                     KGCCGRIGSIITSLELEPTKRPENEYCLYKHNNSCKKCVNKCVKEALKEDGFNRNKCY
                     EMCMINEKKYTYIGGCDICGKCIVGVPCSVINPSR"
     gene            40525..40803
                     /locus_tag="KNP36_001575"
     CDS             40525..40803
                     /locus_tag="KNP36_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873453.1"
                     /translation="MSYKKAIHILPEELLELIQEYVDGECIYIPRKSNNKKEWGSNTP
                     TREELSIRNMQIYEDYQVGYDLQYLSEKYYLSLKSIQRIVLQEKRKDI"
     gene            41096..41671
                     /locus_tag="KNP36_001576"
     CDS             41096..41671
                     /locus_tag="KNP36_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1062 domain-containing protein"
                     /protein_id="HBF0873454.1"
                     /translation="MKKITWEVEYISQLPVIRYCKKCGKKTEYICSGLFRVNAQHKYL
                     DIWLIYKCSNCDSTWNSTIYSRVNPKSLNPEILEQFHTNDYNLVKQYAMNMELLHRNG
                     AEVGIPEYKIVGQEININDLTQVHIISKYPCQLKVSTLLREKLGLSRKVFDEMLDCGI
                     IRSNSGVDLKKGKLNYEIMLDIGKEKQKSSN"
BASE COUNT        15943 a         4867 c         7368 g        13729 t
ORIGIN      
        1 tcatatatta ttgaatatag ttaatactat atattaatgt aatttaaata ataatgacag
       61 ctaaagttca gtataatttg ggaggaaata caatgaataa tcaagatata tatataaatt
      121 tattaaatat attaagtaaa gaggatataa aagtcgatga acctatgaaa aaacatattt
      181 catttagggt aggaggacca gcagatatat tagttagacc tagaactgaa gaacaattaa
      241 aaaatgtact taagttggta aaaaaagagt ctattccgta tttaataatt ggaaatggtt
      301 caaacatttt aattaaagat ggtggaataa gaggagtggt aatagaatta gctgataatt
      361 tcaattctta tgagataaat gatactagga tgactgctca gtcaggagct ttattatcag
      421 ttttagggaa agctctccaa aagcaagaat taaaagggtt tgagtttgca tcaggaatac
      481 ctggcacatt gggaggagca ttagccatga atgctggagc atatggtggt gaaatgaagg
      541 atatagtgaa gtcagtaaga ctgatggata tggaaggcaa tatatttgaa ttatcaaatg
      601 aacagatgga atttgggtat agaaaaagta taatatcgaa aaacggatat atagctttat
      661 cagcagaatt agaattacaa gaaggaaatt atgatgaaat aaaaagttta atggatgatt
      721 tagcgacgag aagaataact aaacagccat taaattttgc tagtgcagga agtacattta
      781 agagaccaac aggatatttt gcaggtaaat taatagaaga aactggattg agaggtctta
      841 ctttaagagg agcacaagta tctgagaagc attgtggatt tgtagtcaat caaggagaag
      901 caagtgctaa agatattttg gatttaatat atgttataaa aagtgctgta tatgccaagt
      961 ttggggttat gttggaagaa gaagtcaaaa tacttggaga ggattaacaa atgaaaatac
     1021 tggctgatta tcatacacat acattatata gtcatggcaa agggactatt gaggataatg
     1081 taaaggtagc catttctaaa ggaataaaaa caataggaat atctgaccat agttataaac
     1141 atattgcata tggtgtaaag aaaaaagata ttctcaaaat gagagaagaa gtagattatt
     1201 taaatgataa gtacactgat ataaatatac ttttaggtat ggagtgtaac atattagatg
     1261 ataaaggaaa tatagatatg gatgataaat ttattagaga ttttgattat attatggctg
     1321 gatatcattt tggttctact ccaacatcat taagaagctt attaaatcat tgtaataact
     1381 atatttttaa aactgaaaaa gcaaaagaat ataatacaaa agctgtaata aatgcgataa
     1441 gtaataatga tatttttata attactcatc caggagataa aggcgatgtg tatatagaag
     1501 aagtagcaaa gacagcaaaa aagacaaata ctagacttga gataaatagt agccattctt
     1561 ttttgaatgt aaatcaatta aataaaataa aagggctaga aaataaattt ataataggct
     1621 cagatgcaca ttgtccagaa agagttggtg attttgaact agctatgaag actatatctg
     1681 actctaatct ggatatatcg ttagtagaaa acattataat ataataaaca taagataaaa
     1741 gggaggagtt agcaatgaaa tttgttatag ttacaggtct ttcaggatct ggaaaaagtg
     1801 agacaatgag agctttagag gatatgggat tttattgtgt agataatcta cctcctgctt
     1861 tgataactaa atttgcagaa ttatgttatc aaccaaattc aagtattgat aaagttgctc
     1921 tagggataga tataagaggg agaaagtttt ttgaagcgct tcatgaaagc ttaaattatt
     1981 tagaaaaaga aaattatgaa tatgaaatgg tatatttgga ttgtaatgat gatgtattgc
     2041 taaagagata taaaatgaca agaagaaatc atccattggc aaaagatatg cagattccag
     2101 aaggtataaa aatggaaaga aagataatgg aacctttaaa ggagttatct acatgtataa
     2161 ttgatacaac taacatgaaa cctaaagacc ttaaggaaga aataaagaaa atatattctt
     2221 ctggtgaaga taatccaaac ctaactattt ctgtagtatc ttttggattt aaacatggta
     2281 tacttgctga tgcagattta gtatttgatg taagatttct tccaaatccc tattatgttg
     2341 aagagttaag agctaaaact ggtgatgata aagaagttag agattatgtt atgaattcta
     2401 aaatcagtga agaattttat gtgaaacttt tagatatgat tcatttttta gtacctcaat
     2461 atatagagga aggaaaacaa catctagtaa ttggtgttgg atgcacaggt ggaagacata
     2521 ggtcagttac tataacaaat cttatagcgg aggatttatc taataaggga tatagagttg
     2581 taaagaaaca tagagactct atgttgcgat aatggaggca aacatggcta aattacttat
     2641 tattgtagga attttaggtt ggattgcatt aattgtatcg ttatttatat ataaaaaagc
     2701 aaaaaatgaa aaagtaaaac tatttcaaag gtctattgtt gaaaatagag aaccaaatgt
     2761 ggttgtgata ggtggaggta ctggtcaatc ggtattttta agaggtctta aacacactac
     2821 gcaaaatata actgcaattg taactgttgc tgatgatggt ggaggttcag gtgtattgag
     2881 agaagactta ggaatgctcc caccaggaga cataagaaac tgtttattag cacttgcaaa
     2941 tatagagcca acaatgaatg aagttatgca atataggttt acagaagggc ttttaaaagg
     3001 tcagagtttt ggaaatttgt ttttggctgc tatgaatggg ttgtatggaa actttgaaaa
     3061 agctgtatat aaattaagtg aaatttttgc tataacagga agagttttac cagtaacttt
     3121 ggaagatgta aatttagttg ccaaattaga aaatggcaat ataataaatg gagaatctag
     3181 tatacctgaa gagtcaaaaa ttcaaaaaag ctctattgat aaaatttttt taaatccaaa
     3241 agatgtaaaa ccattaaagg atgttattgc atctatttat gatgctgaca ttataattat
     3301 gggtcctgga agtttatata caagtataat accaaattta cttgtagagg ggattgtaga
     3361 cgctattaaa tcgtctgtag ctccaaaagt atatatagca aatataatga ctcaaccagg
     3421 tgagacagaa gggtacaatg tattagagca tgttaatgct atagtaaaac acactgatga
     3481 gaatttaata gattatgtaa tcgcaaataa tgagatattg ccagaagaaa tgcttgactt
     3541 atataaacaa gatggagcag agcaagtctt gttagataaa aagcaaaaag ataaattaaa
     3601 agagatgggt ataaaaactg tagagaagaa tttaattgaa ataaaaaata attatataag
     3661 acatgatgca aagtatatat ctaacatagt tattgagtta gccctaaatc ataattacaa
     3721 caaaagttag taaaaaagga ttttaaaaaa ttgtgtagaa atccttatca ttatgttagt
     3781 tttaaggagt gaacatcgat gagagaagag gttagtgctg gtggtgtagt cctgtttggc
     3841 aatacgattc ttttactaag gaagttcaat ggagattggg tgttacccaa gggaaaagta
     3901 gaagaagggg aaaataacca agaggcagca ttacgtgaag taagtgaaga aactggagta
     3961 aaagcagata tattgaaata tttaggtgaa atacactata cattcaaaga aaactgggat
     4021 gaaaatagag cagttcataa aacagttttt tggtatttga tgcaagcaaa gaatatggat
     4081 actattccac aaaaagagga aggctttatt gatgctaaat ttatccacct agatagagta
     4141 gtagacttag ctaggtatga tgatgaaaag gagataataa aggttgcctt acaagaaata
     4201 aaaaaaaggt taaagaaaaa ttagttaata ggtgatagat atgtcttttt caactgaaac
     4261 caaaaatgaa ctagcaagag ttatatctgg gaatgaatgt tgtaatatag ctgaattgtc
     4321 agctctagtt aaatcagggg gaagtataca aattgttgga tataagaagc taaatctaaa
     4381 gataacaaca gagttaaatt caatagcccg taaagtattt aaattattaa aaaagaattt
     4441 taatatcaat actacaatct cagtaaataa gaatcaaatg ctaaagagaa ataacagtta
     4501 tgtattaatg gtaacaagcg aaatgggttc agaaatgtta ttaaaaaagt taggtatact
     4561 tgaagataaa gaaggatttt ttactataaa caaaatttca gagaacttaa ttaagcatga
     4621 aggatgtaag agagctttca taagaggagc ttttcttggt ggaggttcta taagcgaccc
     4681 agaaaagaac tatcatatgg aatttgtaac taataatgag gagtttgcag attctctaaa
     4741 agaacttata aactctttag gttttaatag taaaattgtg gctagaaaaa ataatcacgt
     4801 tgtttatatc aaagagagtg aacaaatatc agatttgttg agtattatag gaggacacca
     4861 cgctctttta agtcttcaaa atactaaaat agtaaaagaa atgagaaata atgtaaacag
     4921 gatagtaaat tgtgagacag ctaacctttc taaaacagta aatgcagcag taagacaagt
     4981 agaaaatatt aagctcatac aagagactat aggaattagc agtttgccag aaaatttaca
     5041 agagatagct aagattagaa tcgagtatga ggatatgact ctcaaagaac ttggagagat
     5101 gttagaacca ccaataggaa aatctggagt caatcataga cttagaaaaa tagaagaaat
     5161 tgcaacagat ttgaaaaaaa aatcatagca ataaattgag gggacaatct cagaataagc
     5221 attaatttat aacatataat ggtatacgtt gaagttaatt cctattttga gataaaagtc
     5281 tctgtttttg ttttaggaca tatatttgtg gtaaaattaa aattataaag caggaggtga
     5341 tttaatgaac aaagattttg ctcatcttca tgtacatact gagtatagtt tacttgatgg
     5401 gttttcgagg gtgaaaaaac ttataaaaag ggctaaggaa ctaaacatga gctcaatagc
     5461 tataactgac catggttgta tgtttggtgt tatagatttc tacaaaacag ctataaaaga
     5521 aggaataaag ccaattatag ggtgtgaagt ctatacagct gcacgtggat tgagagataa
     5581 agacccaaac tatgacaaat atcaaggaca tttagttctg ttagctaaga atatggaagg
     5641 atataaaaat ttaataaaaa tagtttcaac ttcatacgta gaaggttttt actataagcc
     5701 tagagttgac atggaagaac ttaaaaaaca taacaaaggg attatagcac tttctgcatg
     5761 ccttgcagga gatgtagcac gtgctttaat gaatagaaat tatgaaaaag caaaacaatt
     5821 tgctcttgac tacagagaca tatttggaga agaaaatttc tttttggaga ttcaagatca
     5881 caatttacct gagcaaaaag aagtaaactc tggtttagta aaattatcaa aagagactgg
     5941 tataccacta gttgctacta atgatgttca ctatgtaaat aaagaagatt cgaaaataca
     6001 tgatgtactt atgtgtattc aaatgggaaa aacattaaat gacccaaata gaatgagatt
     6061 tggtagtgat gagttttatt taaaatcaag agaagaaatg gaagaattat ttccatatgc
     6121 attagaggct attgacaata ctgtgaaaat agctgatatg tgtaatgtgg agtttgattt
     6181 taatactata catcttccta agtatgatgt tccagaagga tatacaccag aaacttattt
     6241 aagggagttg tgttttaatg gattaaaaga gagatatgat aatcctagta atgagatact
     6301 agagagatta aattatgaat tagatgtaat tgaaaaaatg ggttatgtag agtatttttt
     6361 aattgtttgg gattttataa atttttctaa agaaaataat attatagtag gaccaggtag
     6421 aggtagtgcg gctggttcga tagtagcata tacacttaaa ataactgata tagacccaat
     6481 aaagtactct ctattatttg agcgtttttt aaatccagaa cgtatatcca tgccagatat
     6541 agatatagat ttttgttatg agagaagaga agaagttata gattatgtaa agagaaaata
     6601 tggtgatgac catgtagccc agataataac ttttggaaca atgggtgcaa aagctgcaat
     6661 aagagatgtt ggaagggtat tggatatagg ctacaataaa gttgacaagg tagccaagga
     6721 aataccattt gctttaggaa tgacaataga taaggcccta gatacaaatc ctaatcttaa
     6781 agaattgtat gaccaagacc cggaaacaaa agaaataata aatatatcaa aacagataga
     6841 gggaatgcta agacatgctt ctactcatgc agcaggagtt gttatatcaa aaaatcccgt
     6901 agatgaatat gtacctttgt acaaacatca agatgcaatc acaacacagt ttactatgac
     6961 aacacttgaa gaacttgggc ttttaaagat ggattttctt gggctaagaa ctcttacagt
     7021 tataagagat actcttgatt taatagaaaa aaatagagtt ataaaaaatt acacagaaaa
     7081 aatagacttt tcaaagatgg attatgacga cccgaaagta tatgaaatgc tttcatcagg
     7141 aaatacacta ggggtgtttc aattggagag tgctggcatg agaagtttta tgaaacagct
     7201 aaaaccagac aattttgaag atattgtagc gggaatatcc ctatttagac caggtccaat
     7261 ggattctata cctgcatata taaaaaataa aagcaaccca aaagatgtaa catatctaca
     7321 tgaaaaatta aagcctataa tggaagttac atatggttgt ttggtatatc aagagcaggt
     7381 tatgcaggtc gttagagatt taggtggtta tagttacgga cgaagtgacc tagttagaag
     7441 agccatgagt aagaaaaaga tggacgtgat ggaagaagaa agacaatatt ttattcatgg
     7501 taaatttgat gaagatggta atatagaaat tgcagggtgt atcagaaatg gtgtagaaga
     7561 ggaaatagct aataaaatat ttgatgatat gatagacttc gctagatatg catttaataa
     7621 atcacatgca gctgcatatg gggttttagc atatgagaca gcttatctaa aaacatatta
     7681 tccagttgaa tttatggcag cattgataac cagtgtaatg ggaaatactg ataaggtagt
     7741 tgagtatata agagaatgta aagcactaga aatagatgta ttacctccag atataaacaa
     7801 aagtttttca aagttttcag ttgaaggcga caatataaga tttggtctag cagccgtaaa
     7861 aaatgttggc gtaaatataa taaacaatat aatcgctgaa agagaatcta atggattatt
     7921 tgtagattta gtagatttag tcaaaagatt agaccaaaaa gatacaaata agagagtaat
     7981 agaaagtcta ataaaatgtg gagcttttga taatataagt gaaaatagag ctagtctgat
     8041 ggctggttat gaaagtttat tagaaagtgt atctatggat agaaagaaaa atgttcaagg
     8101 tcaaatttct ttatttgatg cttttggaga tagtgaggaa gatagtgatt ttcaacaaat
     8161 atacagtttg cctaaaaggc aagagtacga agaaagagag agacttaacc ttgaaaaaga
     8221 agtcttggga atgtatgtaa gtggacatcc tttatcacaa tttgaaaaag aactacaaga
     8281 aaaaacatct atggataatg gaaaattaaa ttcattaaaa gaggaagaag agtcatacct
     8341 acaaatgaat gaaacagatg ttataatggg tggaatgatt gtaactaaaa ctattaaaac
     8401 aacaaaacga aatgaaatta tggcatttat tgaattagaa gatttgtatg gtgctataga
     8461 aataatagtt tttcctcaat tattacaaaa gtataatgtc attttgaatg aagataatat
     8521 aatatatgta aaaggaacat taagtataaa agaaggcgaa aatgcaaaac ttatagctag
     8581 agagataaaa gatataaatg atgatactga ctttgcagat agaaactaca attcaggaag
     8641 aactagaaat gtagaaaata ttaagccaga aagtggtaaa aaattgtatt tgaaaataga
     8701 tagtatgtct gatactgata caactaataa tattgtagaa atagccaaac aatatccagg
     8761 taatgacagt atatacttat accctatgga tgaaaatata aatggtaaac gtaaagcata
     8821 taaaatgacc ggggcattga cttgtatatg tgatgaattt ataaataact tagaagagtt
     8881 acttcctaaa gataacataa aagtaaaagc ttgatttttt atataaaaat ctaaatatat
     8941 tataataata tgaaaaatat tgtccgtttt gtgatataat atcacaaaat ggacatttaa
     9001 ggacatttaa tttttttagt cttgatggga ttaaaaagtg atatagggac aaaaaaagtc
     9061 cattagaata caataacaat gattataata aaaaattgac ataaaatcca aggaggtaaa
     9121 aaatgaaaac tataggatta ctaacaagtg gaggagatgc tccaggaatg aatgctgcga
     9181 ttagagcggt tgtaagatca gcaatatatt atggatgcaa agtatatgga atcaatagag
     9241 gatataaggg attactagaa gaagatttaa ctgaaatgaa cttatcttct gttggagata
     9301 ttatacacag gggaggaact atattaaaat cttccagatg tgaagaattt aaaacagaag
     9361 aaggtagatt aaaagcagta aaaattctta aaaagtataa aattgattgc ttagttgtaa
     9421 ttggtggaga tggttcattt gcaggagccc aaaaacttag tgacttagga ttcccagcta
     9481 taggcatacc aggaactata gataacgatt tagcatatac agattatact ataggatttg
     9541 atactgcaat gaatactatt atagatgcta taggtaagat aagagataca tcatcatctc
     9601 atgaaagagt taacatagta gaagttatgg gaagacactg tggagattta gccttatatg
     9661 caggtcttgc aggaggagcg gaaactataa tagtaccaga agtagaaatt acagtagatg
     9721 aagttgctct aagattaaag actactcaaa aaagaggtaa gagacatagt ataatcgttt
     9781 tagcagaagg agtcggaagt gctagtgatt tagaaaagga acttaaaaaa gagtcaggag
     9841 cagatttaag agtcactgta ttggggcatg tccaaagagg aggaagccca actgtatctg
     9901 atagaatact agcaagtaga cttggagtaa gagcagtaga attattatta gatggaaaat
     9961 cagctagagt tgtaggaata aaagaaaaca aaataattga tttagaaata agtgaagctt
    10021 tagctcaaaa gaaagtattt gataaagaag cttatgagat ggcaaaaata ttatctatat
    10081 aagttttagt attaaaaata aatctgtgga ataatatctc aggaggagca aatatgttaa
    10141 ataatgtaaa gaagacaaaa attgtttgta cactaggtcc agcatcacaa agtgaggaag
    10201 ttttaactca acttatgcaa aatggtctaa atgtgtgtag atttaacttt tctcacggtt
    10261 cgcatgaaga acataaagaa agaattgata tggcaaagaa agttagagaa aaattaaata
    10321 agccagttgc tatattatta gatactaaag gtccagaaat tagaacaggt aactttgaag
    10381 acccagaggt atttttagaa gaagggcaaa agttcactat aactatgaaa gatattatgg
    10441 ggactaaaga aatgtgtaca gtaagctata aaggtcttgc tgaagacgtt aaatcaggag
    10501 attctatact aatagatgat ggtttagttg gcttaagagt aaaagaaata aatggagaag
    10561 atatagtttg tgttgttgaa aattcaggaa tagttaaaaa tcataaagga gtaaatgtac
    10621 ctggtgttaa gataaattta ccagcaataa ctcctaaaga tataagtgat atagagtttg
    10681 gaataagtca aggaatagat tatatagctg cttcttttgt aagaaaggca tctgatgtac
    10741 tagcaataag agaagtatta gagaacaata atgcaactga tatacaaata atatctaaaa
    10801 tagaaaacca agaaggtgta gagaacctag atgaaatatt aaaagtttct gatggtataa
    10861 tggtggctag aggtgactta ggtgttgaga taccaactga agagatgcca atagttcaaa
    10921 aaatgatgat aaaaaaatgt aatgaattag caaagccagt tgttactgcc actcaaatgc
    10981 ttgattctat gataagaaat ccaagaccaa caagagcaga agttacagac gttgccaatg
    11041 ctatatatga tggaacagat gcgataatgt tatctggaga aactgctgct ggaaaatatc
    11101 ctgtagaggc agtaaaaatg atggctacaa tagcaaaaag aacagaagag actttagatt
    11161 atgatagatt actaaaggaa aatggtacta acaatgttac tgtaacagat gcaataagcc
    11221 atgcaacttg tacaacagca gtagatttaa atgcatcagc tataataaca tctacttctt
    11281 caggatatac tgctagaatg gtatctaaat tcagaccaaa atctccaata atagctacta
    11341 caaataatga aaagactatg aataaattag ctcttacatg gggagtatat ccagttaagt
    11401 cttctgttgc aggaaataca gatgaagtta tagaaaaggc aattgaggca gctagacaag
    11461 ctgattatat agataatggg gaattagtag ttataactgc tggagtacca gtaggagtaa
    11521 gtggaactac taatttaata aaggttcatg taataagcga agaaatcgtg caaggtatag
    11581 gtgtaggtac tcaaacagta gaaggtaaag ttcgtataat aaagaatgga aatgcttgtg
    11641 tagactttaa tgaaggcgac atacttgttt ctactgctac tgatgctgaa atgaacaatt
    11701 atatagaaaa agcaggagct gtagtaactg agaatggtgg aatgacatca catacagcta
    11761 ttgtaggtat aaatttagat ataccagtta ttgtgtctgc agctgatata acaaatctag
    11821 taaaagatgg agaagttgta actgtggatg catcaagagg cgtggtatat agaggttcaa
    11881 ctagagtttt ataagaaaaa taataaattt atttactaag gggctttata agctcctttt
    11941 tttttggtaa aataaaatat tgtagcttag taaaaaatat agtttaatta atagcaatat
    12001 tttaatataa atttaaagaa aaaagtttgt aaagatttaa atataataga ttgattggag
    12061 ggtgatttat gctttcgaaa aacgagatgt atattgtaga tatagtagac attggtcaag
    12121 gcggagtagg agtaggaaag tacaatggta ttacagtttt tgtagagggc ggattaatac
    12181 atgataaagt taaagttagg attaataaag taaagaaaaa ttatgctgtg ggagatattg
    12241 ttgagataat agaaaagtct ccattcaggg tgaaaagagt gtgtagtgac aatcttaggg
    12301 attgtggagg gtgtcagata caagacttag attataataa acaacttgaa atgaaaacaa
    12361 atgaagttaa acaagtactt tcgagaatag gtaagttaga ggatgtagaa gttcatgaca
    12421 ctataggaat ggataatcca tatagatata gaaataaagc acaatttcca atacaaaaga
    12481 ataatggtat tccaattatt ggcttctata aaaagaagac tcatgatgta atatcgacag
    12541 aaaaatgcgt aatacaacat gagataaatg ataaaattgt taaaataata aaaacatata
    12601 taagggccta taaggtaagc atatatgatg aaaagactca cacggggttg attaggcatt
    12661 tagtaacaaa aataggtttt acaactaaag aagtaatggt tgtattagta gcaaatggaa
    12721 acaaacttcc atatcttaaa gaattagctt cagtgcttaa ggaaaatata cctggattta
    12781 agactttggt tgtaaatgta aatcaaaaag atacgaatgc tattctagga agagaaaata
    12841 tagttatata tggagatgga aaaataaacg attatatagg agacttagtg tttgagattt
    12901 caccattatc atttttccaa gtaaaccctg tccaaactaa agtattgtat gataaggctc
    12961 ttgaatatgc aaatttaaat gatactgata ctgtttttga tatttactgt gggataggta
    13021 caatatcttt atttttggca caaaaggcta aaaaggttta tggaatagaa attatagatg
    13081 atgccataaa agatgctaag ataaatgcta aattaaacaa tatacataat gctgaatttt
    13141 atgttggaaa ggcagaggaa attgtaccta agatgtatag agagggtaag actgccaatg
    13201 tagtcgttgt agacccacct agaaagggat gtgacgaaaa ggtattagag actattgttt
    13261 caatgaatcc ggaaagaatt gtctatgttt cttgtaatcc ttctacttta gcaagggatt
    13321 tagattatct aaatgttcac ggatttaaat gtgttgaggc acaacctgta gatatgttcc
    13381 ctcattctac acatgtggaa actgtagcta agataatcaa acaatagtaa tgtttatata
    13441 gattatatac taataatata ttgtatttgc caccgatttg ccactgtaaa gcgatttcgg
    13501 tggcaaattt agtctacaat gttatcaaaa atctctaaag ttttattttt aattctataa
    13561 aacttattat aattgtaatt ttaaaagaaa tagtcaatct acagtagcca gattttatac
    13621 aactcatttt tttcatagag taatttacat aatctatagt tgaatattat ttaatatttt
    13681 tataattcat tagcaaatat aggcattaca aatgttgata aacatgtgaa agcacatatc
    13741 cacttataat tatttttttt aaaaccataa aatcacctct tcatttgttg tatgttttta
    13801 taacaaatga agaggtgatt tccagacaat ttaaaaggtt tttgtatatt gactaaaatt
    13861 tatttttatt atttataatt cttaataata catatgtacc tactgattcc atattaaact
    13921 gtataatttt tgttcatctt tttttataat taaaactacg tagttctcat aatttctctt
    13981 atatatatac ttatcatctt ttttaacttc taacttatat tttttaaaat cttcttcaat
    14041 tttattttta ttacttttat taatgttaac agaatctctt ttaaatttat caatatattt
    14101 ttctatttca ttaatattat ctttgcttac aactatacca ccttttaaat taaaaacttt
    14161 tttgaaattt ttttcagaaa atccttgaat aaaataactt tgtccatctc cattaatact
    14221 atcttgagta tcaaatactt caatttcttt gttaggtatt ggtatatcaa aattccaaga
    14281 ttcctttagc attgaaatat tagctgtttt tcctaaaaaa agattatata ggatacttcc
    14341 taataacaaa acacctatta atagtagtgt gattaataca atttttctct ttttcatttt
    14401 tcgttcacaa ccttttgaaa aaacatgatt taattcatca tttgaaggca tgtcttcaag
    14461 aataattttt gttgtgatag gaatgctttc ttgaaacata tcatttgtaa tatcaaaatc
    14521 ttttctttga ttactcaata tccatttctt ctaatatttc ttttgatttt ttctagtaca
    14581 ttgaatactc ttatatacat tctcctcttt taaaattaaa agttataaaa gaataagtta
    14641 tataaaaaat tattatattt tttaatatag cttatttgca aatttataat tttgttaatc
    14701 taatccttca aactaaaaaa tcatttatat ttacagaatt tcattttaag agatgtttat
    14761 tttcacatag ataagagaat ttaagttctc atatttatta tttgatacaa atttacatct
    14821 ttattatatg tattttaaat aaaaaataaa attatgaata ctagaaatct atcttaatta
    14881 gctttctaac ataaggctat ttaaagtaga taaaactaaa aagggttctc tagaaaacca
    14941 aatctattta attatactta cttactaata ccatcacttg atgcaaacaa gattctacca
    15001 cattttctcc gtactctagt ataaaatcat ctagttgtgt atctataaaa tcacaataat
    15061 catatgaact accaatataa gcagtcaaca tatgtgtaca tctatccatt ttatctctaa
    15121 acatatatat tattatcccc ctaaaaaact ttcataaaaa caaaaagaat atctcttttt
    15181 ggcaactggc tgacataact catagtttat tttataagcg ttagtcccta tagctttgcg
    15241 tcactaaatt tctctagttt tgccgattta gttttattct acaattacaa taatacaata
    15301 gaattgctta ttattcaata tacttatttg aaaattaaat aaatttacaa atatgaacgt
    15361 tattttatat caaaaaaaat agactatgca tgtagaatat atggaaaaac ttgattgtag
    15421 gttttgtatg aaaagacagt tgttattaat ttaagtgaga taaattgagc aacaggcata
    15481 aaatgagaaa acaaataata gcagttaatt tttattatta atactaggtg aacattaaat
    15541 ttcaaaatac cactagattt tatagaataa gaaaatgaga caaacataaa tatatgaata
    15601 tattaaatta tacttgaaca tacttatatt ttatgataaa atttcaataa taattattag
    15661 tgaaggagtg tcttgcctga tgtcagagtt atatataatg gtaaccaaca aataaatagt
    15721 tggagacgca tatgggttct gtttaatcag aatttttaag tgtatttttg atacatttga
    15781 ttgttgtgtc ttactctgcc tttatagata actaacatta gacaacaaat aataatatta
    15841 catattactt tgttaaattg tggtgtagtg ggctttaatc tgctacactt ttattaattt
    15901 tacacagtat tattttgaat ataattatgt tgaaatagaa gatactaaat tttctagtcc
    15961 acaggggttt tctgtttttg tgtaggtaaa tatgtatacc acataaaaag gcagatataa
    16021 atacctgtgg actttttttg tagaaaatac acgatacgga ggaaataaaa atgaattata
    16081 aaaatagaaa acgagcttat tatcaggaaa attcctgtat ggataacttt atttgcaaaa
    16141 attgtggttg ccttgtagtt cctgaaggag ctggtacaca acatagaaat cattgtccac
    16201 attgtttaca tagtcttcat gtagatatca ttcctggtga ccgtgctgca gattgtgatg
    16261 ctaatatgga acctattgga gtgtgggtga gaaaaaatgg tgagtgggca attattcatc
    16321 gttgtacacg ctgtggacat cttagttcta atcgtattgc agctgatgat aattcagtga
    16381 aattaatgtc aattgcatta aaaccactgg cacagccccc tttcccacta gaaagaatca
    16441 ttgaaaagtt ggaaaaggag gaaacagaat gaatggtatg aaacaaatca atttacaaga
    16501 ctatggtcta aatagaaatt ttattactca aagtatggaa tatcatgatt tataccttgc
    16561 tcggattatc tcgcaggaaa agaactttta tcaagctgta tgtgtaaatg gtgtactgtt
    16621 tgcagaggtt tcaggaaagc tgcgttttga ggctactata caatctgatt ttcccacagt
    16681 tggtgatttc gttatgttgg atcgttgcaa taataaaaat ggtaatgcta ttattcatca
    16741 tgtgcttcat agaaaaagct tgtttgtgcg taaggctgct ggaaaggtaa atgaggagca
    16801 ggtggttgca gctaatattg acattgtttt tttgtgcatg tcactgaata aggattttaa
    16861 cattcataga ttggagaggt atctgtcttt aacatgggaa agtggagcta tcccagtagt
    16921 agtacttact aaatcagact tatgtgacaa tgtgcatcgt aaattacaag tagttaattc
    16981 tatagccttg ggtgtagatg tagttgttac ctcatctata gagccagatg gttataaaca
    17041 gatttctaag tatattaaac caggctgtac tgttgcctta cttggttctt caggagttgg
    17101 aaaatcttca ttaattaatt gtctgatggg tggagaattt ttaaatacaa aggaaattcg
    17161 catagatgat gataaaggaa gacatgccac gactagacga gagctatttt taatttcagg
    17221 tggtggtatt gttattgaca caccaggtat gagagagttg ggaatgtggg atgtttcaga
    17281 aggtttagat aaaagttttg cagatataga agcttatttc ggaaaatgtc attttcgtaa
    17341 ttgtactcac acctcagaac caggctgtgc tatctgggaa gctattgctc atcaagaact
    17401 ttcgcctaaa agatgggaat cctatcgtag gcttaaaact gaagcagtat ttgcagacaa
    17461 taaaagcgaa tacttagcaa aaaaagaaaa gaaatttaaa aatatctcaa aaataaataa
    17521 gaagattaga agataagtgt agtttttttg ttcattctat gagtctatat actattaata
    17581 tattaaattt gccatcaatt tgttacttta atgtgatttt gatggcaaat ttggtttgtg
    17641 gtattattta aagcaattta ttaatttttt taataaagtt tgatttttta tatgatgata
    17701 tatacatgtg ataatgtata catatttgtt acgataggct cctttataaa gaggtcttat
    17761 gtaagataag aaaaggcata tttatactaa tacataatag agtatatgct tatgtatgat
    17821 agagatgttt cttaagagca aaactgcaat attgctaatt tataaagtaa aaatatatga
    17881 attataaaat acaaataata tatttataaa aattattgtt ttaatttata ataaaaattt
    17941 tttgttgaaa ataatgctcg aacctataaa actattaact aatatttgta aatgtatact
    18001 tttgatgata aaatataatt aagttaagtt ggtttttata aacataaatt tattttaagg
    18061 aggtgaaata aatgaaaata tctagtcaat atagaagtca atattcattt agatatgaaa
    18121 gtaatataaa taatacaaga ataaatgaaa gtatggttaa gaaaaatgaa actgtaggaa
    18181 aagacactta tttatctaat attatgaaac aaaagcaaga acttaatgat agaattagag
    18241 atttaaaata tagacaagag gtttatacta aaaaaataaa tgacgcaatt aagaacttat
    18301 gtaaatcaga aataagagaa acaactaata atttttctaa tatagaaata ggtattaaaa
    18361 atagcattat agaagagaaa aataaaagta caatgttaga tgaaaattca acttatctaa
    18421 atacaaatga tgaaaaagaa tctttaatca ctaaagagtc taatgaaaaa attgaagaag
    18481 aaatattaaa tgatgaaaaa ttagaagagt tagaacaaaa aaaggattat aaagaggatt
    18541 ctaataaaaa agagaaagta tctgaggact tatctttagt aggtaaaact cgtgaagagc
    18601 ttgaaaatat gcttaaaaat tttataaatt taacacaaga agaaataatg aaacttgagt
    18661 cgagaataga aaagttagat aaaaatgctg aagaatacaa acaaaattca aagactaata
    18721 tatttgataa aacagatgaa caaaaaaaac atataaatgt actgatttaa acaatatgtt
    18781 ttaaaaaaat aagtttatta tataatgaaa atataaaggt acaatttcaa tacacttcta
    18841 ttaaaccaat aatttatgaa ccagacttaa tttcaattta ctaataacca tatatttatg
    18901 agttaatagt tttatgtttt aaaaagaatt aaataagggg gagtagtatg aagaagaata
    18961 tattaactac tatgattacc atgattatta tattgatgat gagtatgaca gtaatggcag
    19021 agccatatca agaagatgaa acatctagct tgaaaaaaca gagtgcaaat gaacgtaatc
    19081 agactaatat aggcacaatg gatggcagag tgcaaacaaa tgcaataagt aaaggtgcta
    19141 attatgaccc taaatatcct cttaaaggaa tgttaacaca acttggtctt aatacaacag
    19201 gtaaagaggg atgggattta ctctatggag gaaatcccaa tggagttgag cttcgagcag
    19261 atggtaaata ttattatata aataagggta tggaagggct aggattttat gcggcagcat
    19321 tgtcaggtgg ctcatatcag agaataggct ttggaaaact tgaccctata gaagtaatag
    19381 ctgatggaaa ttggatttct tacaaacaag ctcaagatac acttacagta atcaggaatt
    19441 ttttaaatag ctttgactgg agaaatgcat ctgagatgga aagagctaat agagctgcaa
    19501 aattggtaac cgaagcaaaa tatgcagact ctaaatattg taacatagtc tatggtaatc
    19561 tggttgataa acgtggtgta tgtggaagtt ttgcaagtag ctttcattta ttaacaaggt
    19621 taatgggaat ggattcacta tctatattaa atccatcatt aaatcatgct tggaactata
    19681 tacaaattga tgggaaatgg tataggtttg atgggtctga aatatcagct tttggtggat
    19741 cattagactt tgattaccgt aaattaaagg atgcaacaag agagatgact acttactatg
    19801 atgctaaggc attgtctata ttaggattta atcaataaaa atagggggag gcttcttata
    19861 gagccttttt ttattgattt gaaatttaat aaggaatttt atatgaaaat ttaatcaata
    19921 aaagcaaaaa aggctcttta taaagccttt ctaagtgttt ttttaagtaa aattttttat
    19981 atcaacatca gttttaatca aaacatataa cattttggac ttacttttaa aaataaaatt
    20041 attaaaatat aatattaatc atgtttttag tttattatat tctataatag tggtcatgtt
    20101 gactattgta gttttattaa gaatagttgg tttatataaa tatatgcaaa gatagcttgt
    20161 tgtttacttt acttattagt atataggaca agatactcta ataaatttgc ctattttaat
    20221 atcttttgta ctaaaaccaa ctaaagtttc ctttattatt tcgttttgaa taatacaaag
    20281 cataatccga ttgtttgtat aaagactgga aagtatcaga gttattttct aatttagata
    20341 tacctataga acaagaatta ctctctaggc ataattctaa aaccttcttt gccttatttt
    20401 caacattctc ttttgattga ttactatatt caaaaacagc aaattcatct ccaccaagtc
    20461 ttccaataat agcatcattt acgaatactt tagtcaaaat atttgaaaaa tgtattagta
    20521 tttcatctcc tcgaacatga ccaaagatat catttacctg tttaaaatta tctaaatcaa
    20581 agatgtaaaa gtatccatgt gaaacagttt taagcatttc ttttatgtgt acttcaaaaa
    20641 aatgtctatt gtatagtcca gtcataaggt ctttttctga ttttagttta aattcatttg
    20701 ccattgctag tgcttcttgt gctttttcag ttattgtttt agggtaatac tcatctttca
    20761 tttggtcaaa gtttggaata gaatggtgaa catggataag tttaatcata tcatctgtaa
    20821 ctctgtatac catagtaaat cgagtatcca tttctacata gatatctttt tctaggtaat
    20881 ctttttctat tacccaaaga gtaccatata ctataaaagc ttcgtctgtg actttggtac
    20941 atgaatacca ctcatctata atctcaaagt ctatttgctc tgattctgtt tggtcttttt
    21001 caagacctat aataaattct tctaatgttt cgtaaaattc atgttttcct gttccaatta
    21061 atgcaaggtt gtcatctaat aaggaaataa taaatttaag gttttcttct tctggattta
    21121 aaatataaat atgccaaatt ttttttgata aatctcttaa ttgtttttgt attgtattat
    21181 tttccataga ttaccccctt aagatttaca gtttatattt taatgtatta taagttgaac
    21241 tcttattaca atattattat aatatagaac taaagaaatt acatcctgta taggtaaaag
    21301 tatatctttt acaataaaaa tattacagta aaatgaccag ttttaatata cgtattatat
    21361 ttttaattta taaacgaata ttataaatga aatttaaatt caaccttgaa gaaataagct
    21421 aaatgtatta gtatattaat ccatgcttga acataaataa cctttatgat atgatatcaa
    21481 taataatatt atgagaggag tgccttgatg tcggagttat ataatggtaa ccaacaatta
    21541 aatagttgga gacacatata ttctgtataa tcagaaattt caagtgtatt tttaatacat
    21601 ttaatttttg tgtcttattc tgcctttata gataactgac atatgacaac aaatagtatt
    21661 taaaatatat attactttgt taaattatgg tgtagtaggc tttaatctgc tacactttta
    21721 ttaattttgt atagtattat tttgataact attttgaaat agagagcatt aatttttcta
    21781 gtccacagga gttttctgtt tttgtgctgt taaatataag cacagaaaaa ggcagatata
    21841 tacctgtgga ctttttttat ataaattatg aaatatggag gtagttaaaa tgagtataat
    21901 tgaacttaat gaactgacta aagcttatag aagatttgag aaaaaggcag gatttatggg
    21961 gagtgtaaag tctttattta ataggaaata tacagaaaaa acagctatat tgtcatttga
    22021 tttaaagata gaagaaggag aatttgttgg attaataggt caaaatggag ctggtaaaac
    22081 tactcttatt aagatgttaa ctggtattat tgcaccgtct tctggagaaa tatctgtaat
    22141 gggttattac cctaacaaat tagaaaataa ttttaaaaaa caatatgctg ttgttatggg
    22201 ccaaaaaagt caactattct ttgaattgac accagcagat acgtttcttt tatttaaaga
    22261 attatatgat atatctaatg aagaatataa aaaaaacttg gattacttta tcgaattatt
    22321 tgaggtatct gactatttaa atgttcaagt taggacgctt tctttaggag aaagaatgaa
    22381 aatggaacta atagtagccc ttctacataa tccaaaaata ttatttttgg atgaaccaac
    22441 tataggctta gatgctatag cccaaaaaca aattaggtat ttcctaaaag aagtaaatga
    22501 aacaaaagga actactatta tacttacttc tcattacatg gaagatatta agagtctctg
    22561 tagtagaagt attgttgtag aaaatagccg taaaatatat gatggttcta cagagaaact
    22621 atttaatcat tttcaaaaat ataaaaaaat aacagttagt ttttccaatg aaactaacat
    22681 tgtatttcca aaagattgta aagttgttga acaaacaaat cataagatat cagtaattgt
    22741 gccaaaagaa agaggaaatg aaacgattaa atggattttt gataaatatg atgttaaaga
    22801 tgtaatgatt gaagaagaag atataggtag tattgtagag agaatatata agaaaggaag
    22861 tgatgagtat tatgagcaac tataatgaag caagttcaaa tgattcaatg ttttataaat
    22921 ttaaacagag tattagaagg tattatgaag tagccaaaat taactttaaa gtgcaactta
    22981 tctggagatt tgatgtggtg gttaatatgg tgtttacgat tgtaaaaatt ttatttgctt
    23041 atattttatg gaaagcaatt tttggtgaaa ataaaatagt ctctggtttt acatttaact
    23101 ctatgttgtc ttactatata ataagctcat ttttagcagg tattgatatg tcaaagagta
    23161 ccagtgaaga gatatgtaat cgtgtaaaat tgggcacctt ttcaaagtac atgattattc
    23221 caattaatgt tcaaaattat tttattgcta aaaattttgg aatgacatgt ttttattttg
    23281 tatttaatat gatttctgca tttgtatgga tttttatatt taaaatagat tttgccttta
    23341 catcaaatcc agttcaaata ttaatttcaa ttttgatgat ttttctaggg tttattttta
    23401 tgatgaaact ccacttcttt attgggattt tgtcatttaa atttcttgag attagttttt
    23461 ttaaaatgat aattgaaaat attgttgaat ttattacagg aacaatgata ccacttgtac
    23521 tcttaccaga aactatagta acagttatga aggtatttcc attttattat acaacatatt
    23581 tgccatctat gttactaata ggtagaaaca gcaatgaggc aatacaagga ttaattattc
    23641 tagcattatg ggttttattt ttttctgtag taaataaagt tatgtataaa agaatgagaa
    23701 cattatttga tggggtgggt atatgatgaa aaaaaatttg aaaataatat ttatgttatt
    23761 aaaaatgaaa ttatcaaaga tgatggtatt tagattcgat ttttttggag cattttttgt
    23821 agatagttca ttatttatat tacaacttct aatgtttaat agtatatatt ctcatgtaga
    23881 ctcaataggg ggatggcaac aaggagagat gttaatattt ataggaactt tctcattaat
    23941 aaatgcgata aatatgacga ttttcttttt tggtatttat gatattccac gaaaaatcca
    24001 agaaggagaa ttagactact atattacaaa accattagac ccactattta ggttaacatt
    24061 tgaaaatatt aatattggtt catcaccatt aattctagca agtatactta ttgttttata
    24121 tggaatatct gagttaaact cagagataac tttagttatg ataataatat atattttcat
    24181 ggtgttattg atgacattac ttttttatga tgtatgtatc atacttagaa cagtttcatt
    24241 ttttgttata tcatcttctg cgataatgag attagaagat aatttattgc caatgaatat
    24301 gaaaattcct ggtgtaatat atgaaggtgt ttttaaagta ttattctatt taatcttacc
    24361 atatggaatt atgtcgacaa ttccgactca aattttggct gggacaataa caattaatgg
    24421 attaatatac tcaattttaa ttgtattttt gtttacattg tttatgtgga gattttggaa
    24481 gttaggtatg agacattata aaagtgcaag tagttaataa attagtaaaa atagacaatg
    24541 tataactata tataaatacg tttcatatga cactaaacta tgtgaacaag tatttgcgct
    24601 aaaggcactg aaagctataa aattattaaa gtaaggattt aaaagtttct ttagtagaaa
    24661 tataattgtg taaaaaagca agattaatta aaactatatc caaataatta gatataattc
    24721 ttatgcagaa aggaggtctg taaatgtcta attgtttgga atatatttta aaaataatta
    24781 atgtacagaa aaataaacaa aatgagtgat gtatattatt cagaaaatca tgaacaagat
    24841 aatctttatg agcaagataa tttactggca caaagattta atttatttac tctattgaag
    24901 tttgcatttc ctactatttt tatgatgatt tttatggggt tgtatacaat cgtagatact
    24961 atatttgtat caagatttat taatacaaat gctctatcag caattaatat tgtatgtcca
    25021 attattaatc ttatagttgg aattggaact atgcttgcca ctggaggaag tgctattgta
    25081 gcacgtaaga tgggaaatgg tgatattgag ggagcaaata aagctttttc tttaatcgta
    25141 ttatcaggag ttgtaattgg ggtaataatt actggtatag gtattgtatt tatggattat
    25201 atcattatat ggttaggagc aagtgaagtt ttaattaaat attgtcgttc atatcttttt
    25261 attatcttgg tttttgcttc tgcaaatata ctacaagtat tatttcaatg tttatttgta
    25321 acagctggaa agcctcaatt tggattatgg ctagtgttag gtgctgggtg tgctaatata
    25381 attcttgact atgtgttcat tgttctgtta caaatgggta ttagtggagc agcacttgca
    25441 actggagtag gatacctaat tcctaccgtt tcaggtatgg ttttcttttc aaaaaataaa
    25501 gggttactta aattttgtat acctagacta gataaaagaa tattatttga agcttgtttt
    25561 aatggttcat ctgaaatggt gggtcaacta tcaacagcag ttactacttt tttatttaat
    25621 gctatgatga tgaaattaat tggtgaagat ggggttgcag ctattacaat aattatttat
    25681 tctcaatttc ttttaacttc gctttatata ggtttctcaa tgggtgttgc accaataata
    25741 agttataact atggaagtga aaataatacg cagttaaatc atgtttttaa gatttgtata
    25801 ttatttattt cagtagcatc tttattggta tttatctttt ctatatcatg ttcaccaatc
    25861 attgtagaga ttttttctca aagaggaagc cgagtttatg aaattgcaag gtctggattt
    25921 tatatatttt cttttagttt tattttttgt gggtataata tttttacttc gtctatgttt
    25981 acagcattat caaatggaaa ggtgtctgca atattatctt ttctacgtac atttggattt
    26041 ataactatag gtttattgat attgccaaat atattaaata taaatgggat atggttagca
    26101 gtaccaagtg ctgagatttt aactttattt ttaaccattt tttgtatatg taagtataag
    26161 aatagatata aatatatgta gatattaaat aaatagttta ggtagatatt ttatgtttta
    26221 ataagtaatt caattagtgg gagatatata ctattgaaaa ttaaagttat aattgatata
    26281 aagaattaat aaaaataaca tataaaagtt taaaagggag ttgaacttaa agtttgatta
    26341 gaaaaagtca attttaagac aactcctttt attttactat tgtattaatc tgtatctgta
    26401 agtgtattag tctaatatta taaactttgg atgaaattaa ttttctatag gttttaatgt
    26461 atcatacact ttattttaaa gaaacttatc ttaattttca tagtgattga atttgtctat
    26521 tagagatgtt actattagta atgtaaaagc aagagtagtg aatataaaaa acaagatagt
    26581 gatactgcaa gattagaata taataaattt ttatggagag atttcaatat ggatacatgt
    26641 tttaataaaa aaatattact tgttgatgat gaaaaggata tagtagattt aattgaagaa
    26701 gtactcataa atgatggttt taaaaacatt attaaagctt ataatggtct agatgctatt
    26761 tcgctgtgta agatagcatg tccagatgtt gtcattcttg atataatgtt accagatata
    26821 gatggtatag aagtgtgtaa aaaaattcga gagttttcat actgttctat tcttttttta
    26881 tcatcaaaaa atgatgatat tgacaaaata ctaggtctta gtagtggggg agatgactat
    26941 ataacaaagc cattcagtcc aagagaaatt gcttttcgag ttaaagcgca attacgtaga
    27001 caacagtatc aaagcattgt accatcagat agtgaagtta ttaaaatagg agatattact
    27061 attgatatag aaggaaaccg tgtatataaa gatagaaatg agattgagtt aactggaagg
    27121 gagtatcatc ttttaagcta catggctcaa aatgtaaata aaattatagg aaaagaaaga
    27181 ctctatgaac aagtatgggg agtatatagt agtatttgtg acaatacaat tatggtgcat
    27241 atacgacata taagagaaaa aattgaagat aacccctcaa atcctaaaat acttataaca
    27301 gttaaaggac taggatataa acttgtgaat agaatcgatt agaatagatt ttaatattaa
    27361 tgaagatatc tcaagttgaa tttttagtta atgaggcatt cttttatggg taaaatcaaa
    27421 tatattttcg ttatctcaac aatgaagaag aggtctatct ctattttgag atagcctcat
    27481 taagtttata tcctggtaat gtactttatc ttctaataaa atttttttag tttatttgca
    27541 gtgaaacatt aactagaaca ttaaaatttg cattgaaata ctaattaaat aatattgtat
    27601 attgtgtata aacttatact aattgttttt ctatattaaa tactttatca atccaacctt
    27661 tataaaattt ttcttcatgg gaaactagga ttatacttcc tctaaactgt ttcaaagcat
    27721 tttgtaaagc atcctttgtc tctgcatcaa agtgattggt tggttcatcc aggataagaa
    27781 aattacaagg agataacatc atacaacata atttaacctt agattgttca ccaccactta
    27841 aagtagatac actccttgaa acatgctctt ccttcacacc acatctggct agatgacgtc
    27901 taatctcttt tgtatttaat tttggatatt tatctgctac tatttgaagt ggggttttat
    27961 caggattttc ccattttaaa tcttgctcat aataaccaat tttaacttgt tctgaaaact
    28021 ggaaatctcc agatatacga ggaatatctt tgactaatgt ctttaacaag gtagatttac
    28081 cgattccatt aaaaccagtt ataactattt tttgacctcc atcaacagag aaatttaatt
    28141 ttggaagtaa agaatagtag tatccaactt caagatttgt tatagtaaga gcattttgag
    28201 ccgatatttc aatttctgaa aattgaatat ttggttttcc tgtaaaacta ggaggagcta
    28261 ttctttctat tttatccaat tgtttttgtc ttcctcttgc aatttttgaa tttactccag
    28321 ctttattttt acgtataaat gtttcttctt tttctatttt cttttgttgt gcttgatacc
    28381 ttctaatata atcttctctt aaatgtgatt tttgtttaag gaactctgaa tattttccat
    28441 gatatttctt aatcatgcca aattctatat caagaatacc tgtagaaatt ttttctaaaa
    28501 agtcaaaatc gtgggaaact acaataaatg ccccattaaa tgtatttaaa taatttgaga
    28561 gccattcaac atgttcttta tctaaaaagt ttgttggttc atctaataat agaacatcat
    28621 ggttagaaag tagtaatttt gctaaaatta cctttgccct ttgaccacca ctaagctctc
    28681 caacaacacg attcattcct attgaatcta atccaagacc atttgctatt ttatttattt
    28741 cattatctat agaatagaaa ttacttgcta ttagttgttc ctgataatct gatgctttga
    28801 ttagatattg ctcattttca gatatagcac ttttttgata gagtaaattc atttcctttt
    28861 ctattttata aagttcttca aatgcagtgt gtaaatagag tgatattgtt gtatctctat
    28921 tgatttctgc atattggtct aaatggccta tattgatatt aggttgccac ttgatttctc
    28981 ctgaatctgg aacaacttct cccaataaaa ttttaattaa tgtactttta cctgtaccat
    29041 tttggccaac tacacctata tgttcacctt tgaataaatc aaagttagct ttctcataca
    29101 gtgatttatc cataaaacat tgtgataaat tagttacttt taataaactc ataattcaaa
    29161 ctccttttct tttattaaaa aatttatgga aataaaaaaa gcagaggaat ggcattgtaa
    29221 aatgccgacc tctgcttttg gaaaaacaaa aggtcataga caagcattgt tgtctatgac
    29281 cagaaaatct atattatcta tcggcaaata ggtaatttta aataagcata gccaaaaaac
    29341 tatactaaac ctatatttgc cgatgaagat agaaagcttt aagctttcag attaacctct
    29401 acacaacgct tcatcgtata catttgtgta gagttaagtt ttctaacaag tttaactaat
    29461 tctatataaa tcataattat tcacatccta atcttagtat taattctagt ttatctgtat
    29521 ttaaattgta cttttgtact ttgtggatta tcttatttat ttaaaatatg ttttattaat
    29581 tatagcttaa gttatgttat cataatactt agttatagtc aataagaaag ttatatttac
    29641 tattattata ttaatttagt aaatctatca ttacaaagtt atttgaagac tcgctatcaa
    29701 taaaatttta tagtctataa gaaaattaag attatgagtt ttataatttt gatataggga
    29761 tactattttc ataaatatta caacatgtag aagtatatgt ctattattgt tgaattttca
    29821 atgatatatt aaggttctaa tatattatac aaaataaaaa cattaattca acttaaataa
    29881 ttttaagtat tatatgtgtt ttgattaaag aaaactaaaa ttttaaggaa aaataacata
    29941 tttgtattaa attttattga aatgattaaa tttatttact taatgtaaat tattagctaa
    30001 aattgtatta aataattaag gaggtgagta gctctggatg aaatagattt aaaaataatt
    30061 aattctctaa aaaagaatag tagggcttca acctctgaaa taagcagaca aattaattta
    30121 tcagtaccag cagtctcaga gcgtataagg aaaattgagc agtcaaattt aattcaaaag
    30181 tacactattc aaattaatcg ggaaaaaaca aaatataagc ttttggcttt tatatttatc
    30241 aatactgatt tatctaaaag tatgaaagaa tttaagaaaa ctatattgga atatgatact
    30301 gtattagaat gtcatcatat ttcaggagag tatgattact taataaaagt attagcagaa
    30361 gatacaagta atcttgaaga gtttatatca gtgactttga aggaaattgg ggggattcaa
    30421 aaagctaata caaccattgt tttatctaca attaaagaag aatttaatac aataaaagat
    30481 attttttaaa taatttacta gtaaagtgtt aattatattt taggaggaaa atagaatatg
    30541 aaagttttag tttttttagc aaaaggtttt gaaactatgg aatttagtgt atttgtagat
    30601 gttatgggat gggctcgtaa cgattatggg catgatattg atgtagtgac ttgtggattt
    30661 aaaaaacaag ttatgagcac atttaatata caagtattag ttgataagac gatagaagaa
    30721 gtatgtgttg atgattatga tgctctagct attcctgggg gatttgaaga atttggattt
    30781 tatgatgaag catatgattc atctttttta aatctaataa gggagtttaa ttcaaaagaa
    30841 aaaataatcg cttctatttg tgtggcagca ttgccagttg gaaaaagtgg tgttttaaaa
    30901 aatcgtaaag ctactacata tcatttgaaa aatggtaaaa gacaaagaca gttaagtgag
    30961 tttgatgtaa atgtagttaa tgaaccaatt gttgtagata aaaatattat aacctcatat
    31021 tgtccagaaa cagctccaca tgtagctttt aagcttttag aaatgttgac atctaaagaa
    31081 caaatggatg aagttaaatt agcaatggga tttaaactgt aatggtttat agattttcta
    31141 agtaatcaga accccagtca cacatggaat ctaaaattgg aataatactc tttccaaaat
    31201 cagatagcga gtattctact tttggaggaa caacaggata aaccactctt ataattaaac
    31261 catctgattc taattcacgt aattgttgag ttaacatctt aggcgttgct ttaggaatta
    31321 atttttttaa ttcattgaac ctcaatatag tgtctttaag atgccaaagt ataagtgtct
    31381 tatatttacc accaatcaat gcaagtgttg cttctattgg gcaactgtaa ttatctaaac
    31441 attttttcat ttttgggctc ctttatttat tttaaagtat ctttttaggt actatattac
    31501 aaaaaagtgc attattgtaa tatagtacca tagtgataaa attatagcat aggttaaata
    31561 aatcatcaac ttagcctaat aaaacaatag gaggtaaata aatgaatttc gttgaacttg
    31621 caaaaaaaag atattcttgc cgtaattatc aagatagaaa ggttgaaaaa gaaaaacttg
    31681 agaaggtttt agatgttgca agaatagctc caactggtgg taatcgtcaa cctcaaagat
    31741 tgattgttat tcaggaaaaa gaaggtataa ataaactttc taaggctgcc aatatatatg
    31801 atgctccatt agcaattctt gtatgtggag ataaagacaa agtttggaca agaccttttg
    31861 atgggaaaca acttacagat attgacacaa gtatagttac agaccatatg atgttacagg
    31921 caactgaact tggattggca agtgtttggg tgtgctattt taatccagat ataattagag
    31981 aagagtttag tttgccagat aatctagaac caataaatat attattgatg ggatatgaat
    32041 ctaagatacc agagagccca gagagacatg aaaaaactcg tgttccttta agtgaaattg
    32101 tttcttatga aactctttaa ttataaaatt aagttattca taggataaat gtaataaagt
    32161 gtttattata aacaaaattc aaaataaata atatctacat ataattaatt ttagtgaagt
    32221 atatctagtt taactagaat gtatacttca ctaatttatt tattcaaaat atttatgagg
    32281 attttaatat attaactaaa atatatcaat tgaattaact tttaaatctg gaaaagcact
    32341 tgaaatatag tgttttatgt catttaaatg gtcttgaatt tgcttttctg atattttatc
    32401 aggtccatat acaaaataca taatattttt agtatctttt gttatagctg ttcgattatc
    32461 agggccatta agaatactag ataatatacc aatattatct gataaaaata aatcatcttt
    32521 tgttaaaata tgttctttac cacctatacc ataaaaatgt tcacttccat ttgctaattc
    32581 tattttcaaa ggtaattcca ttttatcaag gtcatgacct gctgttagaa gaagattttt
    32641 caattctgct aaaaacattg actcaattgt tacacctaca tctgggatac cttttgattt
    32701 taatagaata gattctaatt gaagcaatac agggtaagtt ttcttgaatt ttttataata
    32761 ctttatataa cttgaaacag gctctgtttt aattttttct ttacgattgt attctgggtg
    32821 ttgttctata atatttttaa ttgtagagtt tttaagaact aaaaaatttt ctttattagg
    32881 ttttgaatgt gtaatattta taaccataac tccaaattta atattgggat aaatttcttt
    32941 aactttatgt gatatttcta acataatata gactcctttt tattttatat tttatgatat
    33001 aatcttagca aattaaaagt ggattttgta gttccatttt tatagtaatt ttatagaacc
    33061 acttttggag gtattagaat gtggattacg attaatagaa atagtaatat atcattatca
    33121 agacaaattt attgtgagat aaaagatatg attctggatg gaagcttaaa gtttgagcaa
    33181 aaactgccat catctaggac tttatcaaaa gaactatctg tatctcgtaa tacagtttta
    33241 gatgcatata atcaattaat tgcagaagga tatttggaaa caaggaatgg atatggaaca
    33301 attgtagcta aaggaatatc agggcataaa gttgatttta agttaaatga tacttttaga
    33361 gatgaaaaag atttacatac taataaacaa aaaaattata tagattttcg ttcaggagtt
    33421 ccagaattaa aactatttcc acgcaaagaa ctttcaaagc tatataaaca aatactgtat
    33481 gatttatcag attcggattt cagatatgga agtacagctg gtgtatgggt tttaagagtg
    33541 gaaatatcta agtatttatt tcgtactaga ggaattagat gtaatcccaa aaacattatg
    33601 attgtttctg gttcaacaca aggtttatct ttaatttcac agcttttata caaaagtaat
    33661 aaaaaggttg ctgtagaaga ccctattcat aaaggcttat taaaggttat ttcatctatt
    33721 ggatattcag ttgttggaat taaagtagat gataagggaa tgaataccaa cttaataaaa
    33781 tcaataaagg ggatttcttt tgtttatact acaccttctc atcaataccc attaggaggg
    33841 attttaccta ttcaaagaag actagagctt attaaatgtg caacagagaa tgattactat
    33901 ataattgaag atgattatga tagtgaattt agatatgagg gtcaaccaat tagttctctt
    33961 tatgaactta gtccaaataa agtaatttac ataggttctt ttagtaaaat attatctcca
    34021 gctattcgtg ttggatttat gttattacca gacaatattt tagaaagcta taaaacctta
    34081 aaaatgtact ctgatgttca tacagaaaca atattgcaac atgtattagc tgaatttatt
    34141 ggaaatggag gtttagagaa gtacatattt agaatgaaga agttgtacaa tagaaaacgt
    34201 aagtacctca taaaagtttt aaacacggaa tttaaaaatg aatttaaaat aaaaggtgaa
    34261 gcagcagggc ttcatatagt tgctcatttc tataatgtta aatttacgga aagtttaatt
    34321 cataaaattt ttgaagcagg tataaaagtt tatcctatac aacaatatgc aattgagaat
    34381 atattagaat atgactatga aattatacta ggttatgctc atcttagttt tgatgaaatt
    34441 gaaaaaggtg taaaaatact cagcaaaata atacatatga atcaaggtac atagataaaa
    34501 catgtagcaa tctacatata atagatgtaa ttaagtttaa actttaaaag aaatatatat
    34561 taatattttt gtataaaaat acctgatatt tttttatcga tactttattg ctatacacta
    34621 aattaagata gcaatttata ttaagaaaaa actttttgca taggttataa tacttaaaag
    34681 gagaggatag agttgaaaac aaatacagat gttattatgg agataattga ttatatagaa
    34741 gaaaatctta cagaaaatct aaatttagat aaaatagctt atattgctaa ttattcaaaa
    34801 taccatttac acagaatgtt tacaaatgtt gtaggatgta ctatccatca atacatacag
    34861 aggaggagac ttactgaagc agctagacaa cttatattta cagacaaata tattatagac
    34921 atagctatta cagtaggata ttctacacat caatctttta cactagcatt tagaaattta
    34981 tataaagaat ctccacaagt atatagaaat aaagatgaat tttatcctat tcaacagaga
    35041 tttgttttaa atctaaatca tcaaattcaa agtgaaaaat gtatttctta tgcaaatatg
    35101 aattataaac aaagaagaga tgaaatcaat tcttatctga actttaatat taattgtgag
    35161 gtgaaagtag catgagttta gtgccacatg taattgaaca aacaggtcaa ggggaaaggt
    35221 cttatgatat atattcaaaa ttattaaaag atagaattat atttatagga gaagaaatta
    35281 atgatgctat tgcaagttta gtagtagctc aattactgtt tttagaatca gaagacccag
    35341 attcagatat aattatatat ataaatagcc ctggtggctc tgctacatca ggatttgcta
    35401 tatatgatac tatgaattat gtcagatgtg atgtatcgac tatttgtatt ggtatggctg
    35461 caagcatgag tgctttttta cttgcaggag gaacacatgg aaaaagatgt gctttaccca
    35521 attcagagat tatgattcat cagccaatgg gaggagctaa aggtcaagca acagatgtaa
    35581 aaatagctgt agataatata ttgaaaataa aagaacgatt agataaaatt ctttctgaaa
    35641 atacaggtaa atcaatagaa gatattagga gagatacaga tagagataat tttatgactg
    35701 cactagaggc taaagagtac gggctgattg attatataat gaataggaat gaataaagta
    35761 tcaaagtatc atattaaaat gtctgtttta caaatatata tataatatta aataagagtg
    35821 tctcaaaatg aactttttag tttatgggac actctttttt gtatgaaatt aaatatggtt
    35881 ttatcatttc gacaattatt accaaatttc aagtttaata aattctacta taaaaaatac
    35941 ataaaagata aggttcttta gtaactttct gtcgtcaaaa gtttttataa atttaataac
    36001 aaaacaagag aaaataccat atattactta tgtctgcaat atatagaaga caaaggagtt
    36061 gtacattatg attacaataa gtttgtgcat gattgttaag aatgaggaag aagttatagg
    36121 cagatgctta gaatgtgtaa aggatatagt agacgaaatt ataattgtag ataccggttc
    36181 tacagattcc acaaaagaaa tagtctcaaa atatacagac atggtgtacg atttcgaatg
    36241 gatagatgat ttctctgctg caagaaattt ttcattttct aaagcttcta aagactatac
    36301 tatgtggctt gatgcagatg acataatttt agaagctgat agagaaaaat tattaaagat
    36361 taaagaaagc ttggatactt ccattgatat tgttatggca aaatacaatg tatcctttga
    36421 tgaaaatggt aacccaactc tctcatatta tagagaacga ttgtttaaaa gaagttctaa
    36481 tcataaatgg gttgacccta ttcatgaagt agtacctctt tttggagagg tattttattc
    36541 tgacattgca atatctcata aaaagcttca tagacaggac cctctaagaa atcttagaat
    36601 ttttgaaaaa atgatttcag aaggaaaaac attggagcca agacaccaat tctattattc
    36661 tagagagttg tactataatg ctaggtataa agaagcaata gaaggtttta ctaagttttt
    36721 agactcatca agaggatgga ttgaggattg tatcagtgct tgcagagatt tagccacatg
    36781 ttattactta attaatgatg aaaaaagtgc cttatattca ttgtttagaa gtttcgaatt
    36841 tgatgagcca agagcagaaa tttgttgtga cataggaaag catatgtttg atagacaaaa
    36901 atataaagaa gccatttttt ggtataaggt agcattaaca agagataaga atgatactga
    36961 tggaggcttt aagtcagatg attgttatgg atatatacca tctatacaat taagtgtctg
    37021 ttatgacagg ttaggagaat cagataaagc tatttattat catgaaaaaa caaaagaaat
    37081 caaacctaat gatagtgctg ttttgcacaa tgaaaattat tttagtaaat ttaaaaatag
    37141 ttgatgggtc acaatcatac taaatttgac atattatata tagagcttaa aagctcaaat
    37201 atatcaggag gtgcttttaa taatgagtag aaataaatat tttggaccat ttgatgataa
    37261 tgattacaac aatggctatg ataaatatga tgattgtaac aatggtcgtg atgattataa
    37321 tagctgtgat tgccatcatt gctgtccacc atcatgtgta ggtccaacag gcccaatggg
    37381 tccaagaggt agaaccggcc caacaggtcc aacgggtcca acaggtccag gtgtaggggc
    37441 aacaggccca acaggaccaa ccggtccgac tggtccaaca ggaaatacag ggaatacagg
    37501 agcaacagga ttaagaggtc caacaggagc aacaggggca acaggcccaa caggagcgac
    37561 aggagctata ggatttggag taacaggtcc aacaggccca acaggagcga caggagcaac
    37621 aggagcagat ggagtaacag gtccaacagg tccaacggga gcaacaggag cagatggaat
    37681 aacaggtcca acaggagcaa caggggcaac aggatttgga gtaacaggtc caacaggccc
    37741 aacaggagca acaggagtag gagtaacagg agcaacagga ttaataggtc caacaggagc
    37801 aacaggaaca cctggagcga caggcccaac aggagcagta ggagcaacag gaataggaat
    37861 aacaggtcca acaggtccaa caggagcaac aggagcagac ggagcaacag gagtaacagg
    37921 tccaacaggg gcaacagggg caacaggagc agatggagta acaggtccaa caggggcaac
    37981 aggagcaaca ggatttggag tgacaggccc aacaggtcca acaggagcaa caggaatagg
    38041 aataacagga gcaacagggt taataggtcc aaccggagca acgggagcaa caggagcaac
    38101 aggcccaaca ggagtaacag gggcaacagg agcagcagga ctaataggac caaccggggc
    38161 aacaggagca accggagcag atggagcaac cggagcgaca ggggcaacag gagcaacagg
    38221 tccaacagga gcagatggat tagtaggtcc aacaggagca acaggagcaa caggagcaga
    38281 tggattagta ggcccaacag gtccaacagg ggcaacagga gtaggaataa caggagcaac
    38341 aggagcaaca ggagcgacag gtccaacagg ggcagatgga ttagtaggtc caacaggagc
    38401 gacgggagca acaggagcag atggagtagc aggtccaaca ggagcaacag gagcaacagg
    38461 aaatacagga gcagatggag caacaggtcc aacaggggca acaggtccaa caggagcaga
    38521 cggattagta ggtccaacag gagcaacagg agcaacagga ttagcaggag caacaggagc
    38581 aacaggccca ataggagcaa caggtccaac aggagcagat ggagcaacag gggcaacagg
    38641 agcaacaggt ccaacagggg cagatggatt agtaggtcca acaggagcaa ccggagcaac
    38701 cggagcgacc ggagcaacag gtccaacagg agcaacagga gcaacaggag caacaggtcc
    38761 aacaggtgct agtgcaataa taccttttgc atcaggtata ccactatcac ttacaactat
    38821 agctggagga ttagtaggta caccaggttt tgttggcttt ggtagttcag ctccaggatt
    38881 aagtatagtt ggtggagtaa tagaccttac aaacgcagca ggaacattga ctaactttgc
    38941 attttcaatg ccaagagctg gaacaataac atctatttca gcatacttca gtacaacagc
    39001 agcactttca cttgttggct caacagttac aattacagca acactttacc aatctactgc
    39061 accaaataac tcatttacag ctgtaccagg agcgacagtt acactagctc caccacttac
    39121 aggaatatta tcagttggtt caatttctag tggaattgta acaggattaa atatagcagc
    39181 aacagcagaa actcgattct tactagtatt tactgcaaca gcttcaggtc tttcattagt
    39241 taatactgta gcaggatatg caagtgcagg aattgcaata aattagatta gataagaaaa
    39301 ggcttctaat atcgtattga tattaggagc ttttttaaga atgattgatg aacatagttt
    39361 taatattaat tagtgcgcat attataaaat actattatat aatataaaat aataacatta
    39421 aattggaaat atagaattat ctaggggtga tactatgaaa aataagattg aaatatcaat
    39481 gaacaacttt gtaaaaaatt atcataaatc aaataatata actacaaagt ggcaagaact
    39541 tttgtttgct tatgcatctg ctgaagatga tatgtttcag aagctaaaaa gtgttgtagg
    39601 aacatctcat gctatgccaa aagattttct ggaaaatgga aaaactataa ttacatattt
    39661 tatacctttt gatgaaagtg taaataatag taatattgga gggtttgaat gttctgaaat
    39721 atgggcaaga gcgtacatag aaactaatat gttgatttca aatttaaatg atttcttatg
    39781 tgaagaacta gagaagatgg gggctaattc atatgctatt cctgggtcgt ataattttga
    39841 cagtgaaaaa ttggtaagtg actggtcaca aagacatgta gcattcatag caggtcttgg
    39901 aacttttggt ttaaataata tgcttattac agaaaaaggg tgttgtggaa gaataggaag
    39961 cataatcaca agtttagaat tagagccaac taaaagacca gaaaatgaat actgcttgta
    40021 taaacataat aatagttgca aaaaatgtgt caacaaatgc gtgaaagaag ctttaaaaga
    40081 agatggattt aataggaata agtgttatga aatgtgtatg ataaatgaaa aaaaatacac
    40141 ttatataggt ggatgtgata tttgtggaaa gtgtatagtt ggagttcctt gttcagtaat
    40201 aaacccatca agataatgga tttaagttga ctaataattt taaagatagt ttataatgaa
    40261 aaaattttag ttatcaaaat aaatataata taaaaactaa ataaatgtgt ttaaaaaatg
    40321 gataaataat ttgtgttgat tgacaaccag ttatactgtt gatagactta tatgtatcgc
    40381 tgtgatatat aaggagggtt gagattttat gtttgattta atctttattt ttgcatagca
    40441 agggctattg caactatgaa atttaatata taaatagccc tttgctattc ctaatgaaaa
    40501 attactattt aataggagag caaaatgagc tataaaaaag caatacatat attaccagaa
    40561 gaattacttg aattaataca ggaatatgta gatggtgaat gtatctatat tcctagaaaa
    40621 tctaataata aaaaagaatg gggaagtaat acacctactc gtgaggagtt gtcaattaga
    40681 aatatgcaga tttacgaaga ctatcaagtt ggatatgatt tgcaatattt atcggaaaag
    40741 tattatttat ctttgaaaag tatccaaaga attgtattac aagaaaaaag aaaagatatc
    40801 taaggatgag ccagtatagt tttataatta tactggctca ttttcttttg ataaaagtgt
    40861 ttgaggtata gtttctttta agtggatgat ataatttaag taatttcaat aacttataca
    40921 gtagctaaca aagctggttg taaagtatct aataagaagt agtagctttt tatatgtttg
    40981 aaattaaaat ttattaaaat taggaggtct tgttttgaaa aaaatacttg attatattcc
    41041 accttttcat aactttctat taatttagta atcttataga aaggaaattg catttatgaa
    41101 aaaaattact tgggaggtgg aatatatctc ccagttacct gtaattaggt attgtaaaaa
    41161 atgtggaaaa aagactgaat atatttgttc aggtttattt agggttaatg ctcaacataa
    41221 atatttggat atatggttaa tatacaagtg ttcaaattgt gattcaacat ggaactcaac
    41281 tatatattct cgtgttaatc caaaaagctt aaatccagaa atactagaac aattccatac
    41341 aaacgattat aatcttgtta agcaatatgc tatgaatatg gaacttttac atagaaatgg
    41401 agcagaagtt ggtattccag agtataaaat agtaggacaa gaaattaata ttaatgacct
    41461 tacacaagtt catattatta gtaaatatcc atgtcagtta aaggtatcaa cattattacg
    41521 tgagaaacta ggtttatcta ggaaggtatt tgacgaaatg ttggattgtg ggattattag
    41581 aagtaactca ggagttgatt taaagaaagg taaattaaat tatgaaatta tgttagatat
    41641 aggcaaggag aagcaaaagt cttcaaattg attagaataa ctaacttaat atattttcag
    41701 gaacatcatt taaaaaaata gtggctttaa aaaatttaaa gccactattt tttaatatgt
    41761 tttatattaa tatttaaaat atagtgtgta ttcttcaaaa ttatagcgat aattaaaata
    41821 ttactataaa aaggaaggtg catacttttt atttaacaaa aactagatat taaaaacttt
    41881 tcgaggaata ttttattaaa atcccta
//
LOCUS       DAEHWM010000029        39569 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.030, whole genome shotgun sequence.
ACCESSION   DAEHWM010000029 DAEHWM010000000
VERSION     DAEHWM010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 39569)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 39569)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..39569
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.030"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            31..1143
                     /locus_tag="KNP36_001577"
     CDS             31..1143
                     /locus_tag="KNP36_001577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5009 domain-containing protein"
                     /protein_id="HBF0873455.1"
                     /translation="MNSRIKSIDIIRGLSIALMIVCNNPGTWMRMYPQLRHAVWHGVT
                     LADFAFPFFVISLGVTIPISINSKLKNNKSTLSIILSIFKRSILLILFGFFLNYLGNP
                     DLDTVRILGVLQRMGLVYFVTSLVYLLLKKLNVGSTATIITFLCISTFIIVGYYILAK
                     PYGFELEGSLAQLVDLHFFKGHLYKPEFEPDGFLTSIVAISSGMLGCTMGCVLLKENI
                     GEYKKFFKILVMSIILLIGAFIFNQYFPFNKRLWSSSFVLLMAGSYGILLSIFYFICD
                     IKNKSKIFTPIIALGSSPIFTYMCLEILSHVFWNVPKLTNKVDYPTTLVEWTTYELIT
                     PWAGTTWDSLIFSLLYVLFWVIVMSIMYKKKIFIKI"
     gene            1397..3421
                     /locus_tag="KNP36_001578"
     CDS             1397..3421
                     /locus_tag="KNP36_001578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0873456.1"
                     /translation="MKKTTKLLATGMLSVAMVAPNVALAAENTTANTESNSDININLQ
                     RKSVVLGSKSNASVKFKEKLNADSITLNFMCYDMPLEATLNYNEKTDSYEGVINYNKD
                     PEYLNVWELQSIKINGKDEQKVLNKEDLESMGLNLKDYDVTQEFIISDANSTKAVNEY
                     MRKTSAPVKKLAGATRFETAVEISKQGWKDGSSKVVIVNGELAADGITATPLASTYDA
                     PILLANKDDIPESTKAELKRLNPSDVIIIGDDGSVSQKAVSQIKSAVNVNVTRIGGVD
                     RHETSLLIAKEIDKYHDVNKIYIANGYAGEYDALNISSKAGEDQQPIILANKDSVPQG
                     TYNWLSSQGLEEAYYIGGSQSLSSKIIDQISKIAKNGTSKNRVSGADRHETNANVIKT
                     FYPDKELSAMLVAKSDIIVDSITAGPLAAKLKAPILITPKTYVSAYHSTNLSEKTAET
                     VYQIGDGMKDSVINSIASSLSKHNAPTEPDNSGSAAGKTVVIDPGHGGSDSGATSGLN
                     GGAQEKKYTLNTALATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIH
                     YNASNGSGNGVEIYYKVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDY
                     LYVLRNNNYPAILVECAFIDNKSDMDKLNTAEKVKTMGTQIGIGIEDTVK"
     gene            3641..4327
                     /locus_tag="KNP36_001579"
     CDS             3641..4327
                     /locus_tag="KNP36_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HBF0873457.1"
                     /translation="MSGYTNDECEIPKIKSYPGADKEIASEIDYSIVKGTVLFDLYQR
                     IMDLVLSIIGLVIGLPLIAIFGILIKIEDKGPITYKQERLGKCGRRFYIYKLRSMRTD
                     AEKFGAQWAEKDDPRITKVGKFIRKTRIDEIPQLFNILKGDMGLIGPRPERPNFTVQF
                     NEEIPGFINRLAIKPGLTGWAQVNGGYEITPEEKLKEDIYYIKNRSILLDFKILFKTV
                     KVVLTGDGAR"
     gene            4422..5477
                     /locus_tag="KNP36_001580"
     CDS             4422..5477
                     /locus_tag="KNP36_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp7"
                     /protein_id="HBF0873458.1"
                     /translation="MIKKISTILSLVLLISISSTIGVFADANPKRELIEGSIPEISTE
                     LNKRAFKDSKEVILVNEESIVDSISATPLAYAKNAPIVVTKSKNLGRVTRNYLKELGP
                     EKVTIVGGLKAVSKDAERNIEKMGMKVERIRGKDRYDTSLKIAREMYRTVGFDEAFLL
                     SSTTGLENAISVYSYAAKSGMPIIWAKDEGFEEQIDFLKGKNLKKIYALGDSKEFIAE
                     IDSNLKNIEGIKQINKSSTNVDLIKKFYDEKDIKKIYTARLDFGSRSDVNEYISLGVV
                     SAKENMPILICSDNLSRAQDKFLKDSNINDVVEVGYTVGDYSLFKSIFNLTFLSCIVL
                     ILLLLLITFRALRYESK"
     gene            5592..7148
                     /gene="murJ"
                     /locus_tag="KNP36_001581"
     CDS             5592..7148
                     /gene="murJ"
                     /locus_tag="KNP36_001581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="HBF0873459.1"
                     /translation="MSKTAKAALWIMAATMFSKVLGFLRELVLANFYGTGMYADVFVL
                     TLNIPGLIIAVIGSAVATTYIPMYFETKKRLGDEGALKFTNNVLNICYIMAIVIAIIG
                     LLFTEQFVTVFAAGFRNDPAKFQAAILFTKIMISGVLFLSGSKIFSSFLQVNDSFVIP
                     GLIGIPYNIIIIAAIALSAGKNVWILPAGALLAMASQLLFQLPFAFKKSYKYKPYINL
                     KDESIKELVNLVLPMLVGVAVGQLNIFVDRLLATTLGDGKLSALNYANRLNEFVMALF
                     VTSIITVIYPKLAKMSGKDNKEGFISTIVKSSNCIILVVLPISIGAIILAEPLVRILF
                     QRGKFDALSTDLTSIALRLYSLGLLACGVRDVLYRAFYSLSDTKTPMINGSIALIINI
                     VLNLILIRPLGHAGIAISTSTSNIITVILLFISLKKKNGYFGGDKIIKTGLKSLVASG
                     VMAVATLLIYNNLYAFMGSGTIKEIISVGAGVLGGASVYTVLIVLFKVEEMDLAFEFL
                     RKGKQKLLRR"
     gene            7194..8900
                     /locus_tag="KNP36_001582"
     CDS             7194..8900
                     /locus_tag="KNP36_001582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HBF0873460.1"
                     /translation="MDYKNNYEMWLNSPYFDEQTKNELLSIKDDEKEIQDRFYKNLEF
                     GTGGLRGIIGAGTNRINIYTVRRATLGVLNYIMKTQGEEGKQKGIVIAHDSRYMSREF
                     CIEVAKTLSAYGVKAYIFEELKPTPELSFAVRYLKCAMGIVITASHNPKEYNGYKVYD
                     SDGGQICIDMANDIIAEVNKIDDYSTIKSIDFEEALSKNLITILDNEVDDEFIKAVKK
                     QVLRQNIIDEYGKKLKIIYTPIHGTGNKPVRKVLNECGFENVMVVKEQELPDSNFSTV
                     KYPNPEEKSVFNIAIEMAKNNGTDLIIGTDPDCDRVGIVVKDSSGEYVVLNGNQVGSL
                     LVRYILESLVEENKLPKNNPTIIKTIVTSELGAKIAKAYNVDCLNTLTGFKFIGEKIK
                     AFEESNDRSFIMGYEESYGYLIGTHARDKDGVVSSLMICEMAAYYSSKGMNLYEALID
                     TYNKFGYYKEDLKSVTLKGIDGIKKIKEMMLYFRSVKIDNVADVKVDKILDYKDGVDD
                     LPKSDVLKFLLEDGSWIAIRPSGTEPKIKFYFGANSDNQEDVEFKLNNLISYILNVVD
                     SI"
     gene            8922..9995
                     /locus_tag="KNP36_001583"
     CDS             8922..9995
                     /locus_tag="KNP36_001583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-1-phosphate guanylyltransferase"
                     /protein_id="HBF0873461.1"
                     /translation="MKVYNVIMAGGGGTRFWPLSRQEVPKQLINLSGEDALINETINR
                     IDSLAKKDDLFIVTNEKQLEALKDIVKDKCLDSNILPEPCARNTAAAIGFAAFNIMKK
                     YGDGVMCVYPADHYIKDEKEFKSILEKAIYIAENNDKLVTIGITPTFPSTGYGYINFN
                     RENTIEDVAYEVVEFVEKPNYEIAKEYVNSKKYVWNSGMFVWKVSKILEDFKRYLPKV
                     YEKLEDISKYLGTKEEMEKIKEIYPTIQSISIDYGIMERSNDVIVVPGDFGWNDVGSW
                     DSLGAIYPTDDEGNIKRGENITIDTKNSIIYSDDKLISTIGISDLIVVSTNDAVMVCR
                     KDKAQDVKKIVEQLKEEDRQEYM"
     gene            10007..10729
                     /locus_tag="KNP36_001584"
     CDS             10007..10729
                     /locus_tag="KNP36_001584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBF0873462.1"
                     /translation="MIPKKIHYVWFGGPKGNIENICINSWKEKLPEYEIVEWNEKNFD
                     IEKEIKGNKFLEECYKRKLWAFISDYTRIKVLYEQGGVYMDTDMQILKDITPLLENNR
                     LICGYEDDREYINGAIIGVEKGHPFLKDLLEYYEKEVLTSSLFTIPKIMTHLMEKNYK
                     KIDPNNYEEGIRVYDKEYFYPFGFKEDFTPECITENTFGIHWWGKSWAKKRNYFLESK
                     HLTGVNKIWKCCKIFASNTLRS"
     gene            10745..11902
                     /locus_tag="KNP36_001585"
     CDS             10745..11902
                     /locus_tag="KNP36_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide polymerase"
                     /protein_id="HBF0873463.1"
                     /translation="MKTLNDDRNIMIRKYLYIFVLFIILLRKYMISFIDPNMDIGMIK
                     SALFYSSIGILMLLFLFDKRKSITEMVLVGVCVLLYLLNREGAILLIVLLAVSAKQID
                     DKFIVKNYLIISACFLMVAILLFNLFPSLIFNQEVHYRYIEKIDMLVTRMDFGLGNPN
                     SVFYHMVTIYAAYIFLRYKDYNKWDRIILFGSAFFVYQTTYSRTGFFTILAGLIFVEI
                     IRWIDIKKIKGLPMLLKTLPIILTLFSVIIGTVFDKSTLLNRLLASRPKFWHVYLAEK
                     GNFLKPFGNSYSPAIKATNPLDSSYVYIISVLGVVACILFMYLMYKGIESFIEKDKKA
                     YLVALFIFLLYSFAENLLLEASFSFAVVLLIKEVILNDKREIDLWKMKSRR"
     gene            11905..12744
                     /locus_tag="KNP36_001586"
     CDS             11905..12744
                     /locus_tag="KNP36_001586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0873464.1"
                     /translation="MLISLIMPTLNRYDDIYLLMDSLENQTYKNFELIVVDQNDNSKV
                     KEIVDKYIDKLDIKYIKSSKKGLSYNRNVGIDNAVGQIIGFPDDDCVYENDTLEKVIN
                     FFNKNKDYKIYSCKTMDSNKVDAFKKMYDGTCDITSSNVLDTITSITFFIDFEGKDYT
                     RFDEKLGVGGEFGAGEEIDYVLNLLSLGFKGKYFGNDIIYHPAKKHSKSKEKYQKDYN
                     YGRGFGALCKKEIVYRKNYKFAKVMVSKLVRNIGGLILSSNRDYHSATIKGRINGFRQ
                     YKL"
     gene            12759..13934
                     /locus_tag="KNP36_001587"
     CDS             12759..13934
                     /locus_tag="KNP36_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-glycerol glycerophosphotransferase family
                     protein"
                     /protein_id="HBF0873465.1"
                     /translation="MDKVKFLINMLLAFFIYPFNKHKFNGRDIWLIGGHSGDIYNDNS
                     KFFYEYMLKEHNDVETYWVVNKDSKVFDKIPGKKLIRGSVENYLYYYNSKAIVFSHAP
                     SADIAPYNFAVPVLNYFHKKTIKVFLNHGTISFKKRKPMNKKFKNIIDNLYKSYNIVT
                     ASSEFERNVMVNDWGMLDDSVYIIGNARYDNLPTNEVAQTRDILYTPTWRDWIKFSSG
                     KFTDTDYFKNIMNFLNDDKLNKILDEKDINVKIYMHHLMHEFIDDIKENITGKRIVFL
                     DKGVTLANEIRKSAANITDYSSVAIDFLYMNRPILFYQFDLDEYMEKVDSYIDLKSEM
                     FGSLAYNNDEAVNKLIDIIENNFEVMDNQKNERNKFFRYNDNKNCKRIYDCVLSKIK"
     gene            13963..14712
                     /locus_tag="KNP36_001588"
     CDS             13963..14712
                     /locus_tag="KNP36_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0873466.1"
                     /translation="MKKNLVSIITPMYNSEKFIEATIKSVLNQTYQEWEMLIIDDCST
                     DNSPNIVKSYMQQDSRIKCIKTETNKGVSNARNLALSKATGQFIAFLDSDDQWNSSKL
                     EKQVNFMLENDYVISFTSYELMDENDKKLNKVIKVPPNVDYRRLLKGNILGCLTVVID
                     KSKLDFEIRMSGVRHEDYVLWLSILKKGHIAHGINEVLALYRKSSNSLSGNKIKAAMW
                     TWNIYRNIEKIPLYKAIYYFINYGINGIKKS"
     gene            14734..15642
                     /locus_tag="KNP36_001589"
     CDS             14734..15642
                     /locus_tag="KNP36_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0873467.1"
                     /translation="MYKYKFTVFTPTYNRAHLLENLYNDLKAQTYDFNDFEWLIVDDG
                     SSDSTKELVEKFISENKLNIRYIYKENGGKHTAINLGVKNADGELFFIVDSDDGLIKD
                     SLEIANDEWDSLENKEGFSGVVGLCVYPSGDLIGTEMPEDKKICHFADLYFKYGVKGD
                     KSIVFVTDELIKFPFPERKEVRFLPESVVWNEMSKYYKVICVNKPMIIRDYLDDGLTK
                     NILSKNALRGRALEFLYLINQNTYPLSRYPYMWIKNYINLARYSLLSDSHYFGELRKV
                     SDKLLYLALFPLGYYKYIGQRKLVSK"
     gene            15690..16442
                     /locus_tag="KNP36_001590"
     CDS             15690..16442
                     /locus_tag="KNP36_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HBF0873468.1"
                     /translation="MNEPLVSIITPVYNSEEFLSETIKSIQNQTYKNWQLLLVDDCSK
                     DNSSEIIKSFRKEDARIKYIKLEKNSGAAVSRNVGIKNAEGRFIAFVDSDDLWDSRKL
                     EIQIEYMLKENVGFSFTSYRYMRQDGSKTNKVARAPKKIDYEGLLRNTIIGCSTVVID
                     KEIVGEFSMPLVRRGQDTATWLQLLKKEKYAYGIQEDLVNYRLVGNSISSNKIKALKR
                     TWNTYRNVENLSLPKSLYVFCFYVFNAIKKRV"
     gene            16396..17763
                     /locus_tag="KNP36_001591"
     CDS             16396..17763
                     /locus_tag="KNP36_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="HBF0873469.1"
                     /translation="MYFVSMFLMPLKKEYKFYILGGKKMKIAIAGTGYVGLVTGVCLA
                     EVGNENVVCVDVDEQKVKSMKLGIAPIYEEGLEELMVKNYNRGRIDYTTDYKKAYEDV
                     DVILIAVGTPERSDGSANLDYIKAVAKQIAETVTKDTLVVIKSTVPIGTNEEIEDYIN
                     RNLKNDVKVELASNPEFLSQGTAVKDTLHASRIVIGVESEWAREILEEIYKPFNQPII
                     VTNRNSAEMIKYASNNFLALKISFMNDIANLCEIAGANIEDVALGMSYDDRIGSKFLK
                     AGIGYGGSCFPKDTKALHWLSEHNGYELKTVKAAIEVNESQKLKLVRKASKLVESFQD
                     MKVAVLGLTFKPDTDDIREAPSIPNIKYLLERGARVTVYDPIGVNNTKKIFGDSILYA
                     DSVDDAIEDAEICFIMTEWKDVLNYDIHKYKEKMKNPLVLDGRNCYKIKDMEELGIEY
                     YSIGR"
     gene            17769..18860
                     /locus_tag="KNP36_001592"
     CDS             17769..18860
                     /locus_tag="KNP36_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBF0873470.1"
                     /translation="MKTVCYLADGSNPHTLKWCSFFKNKGYDIHVISLNGGHMEGIKI
                     YNFGSNVEELKNENISKKTGYLGSIKQIKKLVNEIKPDILHAQYASSYGFIGSLLGYH
                     PYIISVWGTDIYDFPNNGFIQKQIIKHNFRKADYIFSNSRDMAKEANKYTAKHVDVTF
                     FGVDMDRFKPMEVEKEDAFVIGIIKSLEKKYGIEYLIQAFKMLKDEYKDKKIILKIGG
                     SGSQMDNLINLAKELGIENDVQFLGRISPENVSKTFNSFDVTVFPSLREGFGVAAIES
                     EACEVPVIVTNVGGHPESVWENETGLIVEPKQPEEIKNAIIKLMENDELRLNMGKKGR
                     QFVRENYEVNLNFNDIEKIYDSIFDKYKK"
     gene            18944..20857
                     /locus_tag="KNP36_001593"
     CDS             18944..20857
                     /locus_tag="KNP36_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBF0873471.1"
                     /translation="MRESIDLEKESFFNRLFKKYKFRHLTLLILDICSVLVAFRMSLS
                     LTGNLNAFTTNDIIISACIYIVLHIVSFRLFKCYNTLWRYAGEEEIISIFVATLAYLI
                     PIYIINKLLGFDYPIMFYVLNTIFIIMFTSGARIAYRAIRIVMNKTYSRGKVSNILII
                     GAGDAGEMVIQELKRNPELKKVAVAIIDDDKNKIGRIIHNVKIVGTTSDIKDVVEKYN
                     VDEIIFSIANIEKRRKKEIIDICKNTNCKIKTIPGIYEIIDGKVDIKQIREVEIEDLL
                     GREPIKTNLREISNYIEGKVILITGGGGSIGSELCRQIAGFNPKELIIVDNYENNAYS
                     IQQELLRKYKNKLDLKTVIASIREEKRMDEIFNKYKPEVVFHAAAHKHVPLMESSPGE
                     AIKNNIFGTLNIAGLSSKYRAKKFVLISTDKAVNPTNIMGATKRAAEMIIQTMNAESQ
                     TEFVAVRFGNVLGSNGSVIPLFKKQIEDGGPVTVTHPDIIRYFMTIPEAVGLVIQAGA
                     MAKGGEIFVLDMGEPVRILDLAKNLIKFSGFEPDVDIKIEFSGLRPGEKLYEELLMSE
                     EGLLDTEHKKIFIGRPIDVDREKITKYLKLLREITNNEEVEKIDGIMRELVPTYIKPE
                     DANIKEIATTREK"
     gene            21056..21763
                     /locus_tag="KNP36_001594"
     CDS             21056..21763
                     /locus_tag="KNP36_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBF0873472.1"
                     /translation="MMNIKNKKHILKKFIAMVLIAGVVTVEAGAITASAAEPTNSPMS
                     ATVDQCDFLNVRSGASANDAVVGKINTGDKVEVLELHSNGWIKIKSVDNVTGWVNGDY
                     LTIQGGNVDAKVQNVLNLAFKQQGKPYKWGATGPNSFDCSGFTSYVYKNGAGVNLPRV
                     SRSQATVGKKVSRAELKPGDLVFFGSGGSINHVGLYVGDSKFIHSPQTGDVVKVTSMA
                     PGTNYARRLITATRVLQ"
     gene            22065..24176
                     /locus_tag="KNP36_001595"
     CDS             22065..24176
                     /locus_tag="KNP36_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding glycosyl-hydrolase Cwp19"
                     /protein_id="HBF0873473.1"
                     /translation="MKKISILVLSLIMTLTMCSVSSFADSSNDKEMRAAWISTVYNLD
                     WPKTKNNEAKQKKEYTDLLDKLKSVGINTAVVQVRPKSDALYKSNINPWSEYLTGTQG
                     KDPGYDPLPFLIEEAHKRGMEFHAWFNPYRITMADESIDKLPANHPAKKNPSWVVKHG
                     NKYYYDPGLPEVRKYIVDSIAEVVQNYDIDGVHFDDYFYPGVSFNDTATYQKYGKGQN
                     KDDWRRENVNTLLRDVKASIKSIKPNVVFGVSPAGIWRNKSSDPTGSDTSGNESYVGT
                     YADTRAWIKQGLIDYVVPQLYWPIGLKAADYSKLVAWWANEVKGTNVDLYIGQGIYKQ
                     GQSSYGGQNIAKEIVQQVTLNRKYSEIKGSMYFSAKDIANSTSIQKDLKSLYSSSEEP
                     VTPPSNVKVEKLRGDERYDTAVAISKKGWATNSDTVVLVNGYSIVDGITSTPLATSND
                     APILLVNKDNIPTSTKNELKRLNPSKVILIGGNNSIGDKVESEIKDTLSNVSINRVGG
                     SDRYSTSLMIAKELVKTNPVEKLYITSGTGEADSLSIASKAGEEKQPIVLVSKDNVSD
                     EVYNWISDLKVKDAYFIGGNLSISDSVINKLDKVITNDVSKNRIAGENREETNGKVIQ
                     KFYPNAEYSSMFVSKSNQLVDALTSGPLAAKLKSPVVMLGNSVTSAQKTALEPKKTTL
                     VYEAGDGINQNTLNTFLNLVK"
     gene            complement(24374..25339)
                     /locus_tag="KNP36_001596"
     CDS             complement(24374..25339)
                     /locus_tag="KNP36_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HBF0873474.1"
                     /translation="MSKLKKFVILLAFLVVIFPISVYGYFYYKLSAIHDSSISSDLLD
                     NNDHKNEDGIINILLMGTDARPNEDSSRSDAMMILTIDNKHNDIKLTSLARDSYVDIP
                     GHGKQKLTHAYAYGQADLLIQTIEENFNIDIQNYACVNFESFMYIIDAIGGVEVTVEK
                     GEIRELNKFIPETYKWNKSDDKGSIQYIRNSGKQTLNGYQALSFARIRHNDTAFARDG
                     RQRQIIQAIIKKTETLPVTKYPGLLDAVLPYVKTNMKPNAILSLGAQVLKMGDLNIKQ
                     FEFPIDDEIHSTGGIYGKAGWVLRFDPDTLDILHDFIFNDIEFKQ"
     gene            complement(25624..26580)
                     /locus_tag="KNP36_001597"
     CDS             complement(25624..26580)
                     /locus_tag="KNP36_001597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HBF0873475.1"
                     /translation="MSGLKKFVIFLALLVIAFPVSIYGYVFTKLKTIQDDSINTEALS
                     SNDYKNEENITNILLLGTDARPGEEVSRSDAMMILTIDNKNKSLKLTSLNRDTYVNIP
                     GRGEQKLTHAYVYGQANLLIETIEENFQLDIQNYAVVDFFSFMDIVDALGGVTVTVDK
                     SEIRELNKFIPETYKWNKNDNKGSLKYIRNSGEQKLNGYQTLAFSRIRKNDSTDERDR
                     RQRSVIQSLINGVKDLPVTKYPNLVNTILPYVKTNMNPNEIISLGKELLSIGNLNLKS
                     MEFPLSTENGRKIGNAGYVIPFEEYELDAMHDFIFKDIMVED"
     gene            26948..27736
                     /locus_tag="KNP36_001598"
     CDS             26948..27736
                     /locus_tag="KNP36_001598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBF0873476.1"
                     /translation="MIKLIATDLDGTLLDEKSEINPEFYKVFKKLRERGIMFSAASGR
                     QYQNLIKKFEDIKDDMMFISENGTLVVYKGKEILSNPLNKELVNEIIETTRSIKGKKI
                     VMSGKKYAYIESKDEAFIQEVSTYYAKFKIVEDLTKVEGDILKIAVFDFKGAEHNNNI
                     YFEKFSDRAQVCISGVEWLDLTAKGANKGSAIKKVQKMLDIKYEETMVFGDQLNDVEM
                     MKSAYHSYAMENANEHLKQIARFRAKRNTENGVVDKIKEVIKIG"
     gene            complement(27859..28329)
                     /locus_tag="KNP36_001599"
     CDS             complement(27859..28329)
                     /locus_tag="KNP36_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4358 domain-containing protein"
                     /protein_id="HBF0873477.1"
                     /translation="MKKILILFFSIILSLGMVSCSSSGDYKNVSTSKIKKALKSSDLL
                     IKESKIFDAKDFNYFNDVEEDIIQGFVINSSEKLSLEDIIVIKTDEVDKIYKTLENYK
                     KDMIQAPFGEGHGEKINSEIANNTIIEKAGRYVYLISAENATQIENKILNIIKK"
     gene            28468..29112
                     /gene="uppS"
                     /locus_tag="KNP36_001600"
     CDS             28468..29112
                     /gene="uppS"
                     /locus_tag="KNP36_001600"
                     /EC_number="2.5.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="di-trans,poly-cis-decaprenylcistransferase"
                     /protein_id="HBF0873478.1"
                     /translation="MRIPKHVGIIPDGNRRWASQNGMTKDKGYESGIDPGLESYRLCR
                     DLGCEEVTFYGFTTDNTRRPSVQTKAFTKACIDAANILIDEGAALLVVGNTKSPMFPE
                     ELLPYTNRIKAKEGQIKANLLVNYGWYWDLNNISGVENVNKNNIQDYIQSFDVSRLDL
                     IIRWGGRRRLSGFLPVQSIYADFYVIDNYWPDFKSDDIKDAFSWYDTQDVTLGG"
     gene            29155..30060
                     /locus_tag="KNP36_001601"
     CDS             29155..30060
                     /locus_tag="KNP36_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861670.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0873479.1"
                     /translation="MKKKLLDGKITLIICKSVKIYTKKGEEMSKGNNNNNSRNKSKKT
                     SHLNRKKRKLNKKKLAVLICFTVLFLFIAFKATQGVVALVKSMDKSNKTNQQQNVNSE
                     QFDLGNEEENKKKKYTVFIDPGHGGNDKGTESKTSNRYEKDLNLQIAKKLANKLSKQK
                     DIQVVVSRTDDTYISLKDRAILANNSSADVLVSIHLNAEKNGNTATGIETWYRNKATD
                     GSKELAQTVQSTIVSYVKVRDRGIVENNFEVLRESNMPAILIECGFLTTPSEEQKIIN
                     EKYQDQLAEGIVQGVLSYLDSKGNK"
     gene            30375..31922
                     /locus_tag="KNP36_001602"
     CDS             30375..31922
                     /locus_tag="KNP36_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0873480.1"
                     /translation="MNKNSMTRIYSLNKIIFIIIGILGIVLLTRHIEVDIKVLILILL
                     TLFSINVFISYLKIKLYEDKINLGLINNSDKFINITKDENFLKHVQNYIISNEKENCV
                     MACFDLCRLKLINDIYGYELGDEVLNNILSNLKNYFGKEAIYGKLKSDVFVLIIKLEN
                     REQKIPYLVNLIKNKIVILSQIDSFKMDINIEASIGIYKFNNNEIDIKKAIDNADMAR
                     LKSKGLKHIEYVEFDNAMEEEIQSIMKIERDLFLAIKNKEFVIHYQPKVDSSTGNIIG
                     SEALIRWLHPSLGMVGPNKFIPIAEKNGLINNIGRWLIQEVFITINKWISEGINVLPV
                     SINLSRVELYKNDLVDFFKLMFNTYNIPKELIELEITETTALRDVKFISERLYEIKSL
                     GMNISLDDFGVGNSNFINLKGIPLDIIKIDRSLILDIVTNTKTKFMVKAIVNLSHDLN
                     VTVICEGVEDMHQVKVLSELGCNFIQGYVFFKPLDEMNYKKLLTDGSYINLKDTLLDK
                     CMTVEEE"
     gene            31925..32323
                     /locus_tag="KNP36_001603"
     CDS             31925..32323
                     /locus_tag="KNP36_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HBF0873481.1"
                     /translation="MISEDVDYSIRIIRAIFNNGEDKPIDAKMILKSEDIPILTLYRL
                     LRKLCANNILTFNKEDGKTYMLNVSLDTISLRTIVEVIDGKIYINKCTRYVSNCSNCL
                     KGCKVNRELLEIEKEIYKLLSRKSIRQILE"
     gene            32363..34096
                     /locus_tag="KNP36_001604"
     CDS             32363..34096
                     /locus_tag="KNP36_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HBF0873482.1"
                     /translation="MDDISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKT
                     LKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIH
                     RHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSLKKKWRYKFD
                     YIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVIT
                     PRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYID
                     VFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKC
                     KYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEY
                     RLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKK
                     IMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKI
                     TAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIK
                     MDNLIMDSLGI"
     gene            34328..35539
                     /locus_tag="KNP36_001605"
     CDS             34328..35539
                     /locus_tag="KNP36_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBF0873483.1"
                     /translation="MKGLVLEGGGTKGAYQIGAYKALRELGIEFQGVTGTSIGALNGA
                     YIVQNDIEVMEDIWLNYDYTHFMNIDRETYERFKNVDFTTKNLNAVFELINKARKNEG
                     IDISPLRQLMETTLNEDIIRKSKKDFGLVTVWWDKKINPYPLYIEDIPKGRLIDYLIA
                     SSSLPIFQTNMMDDKLYLDGMFCDNMPIGLLEDKGYEDVVVIRLIDDFIGKMNLNRHQ
                     NINIKTIIPSEYLGGSLNKDRDNVEKNIRLGYLDTMKAYERCTGIKYYFDVEYKYNEE
                     YCFDKFRSMSNETIQYICNLLNIKRDASLRTVMESVIPKLGEVLGLPKDFSYKDLFYC
                     IYEKKLEENNINRIKLYDFNKVIDVVNTNIDSNRNLASNFEVRPKISIKKNKNTKLLT
                     NCIIKDIKNQS"
     gene            35732..35992
                     /locus_tag="KNP36_001606"
     CDS             35732..35992
                     /locus_tag="KNP36_001606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr family phosphocarrier protein"
                     /protein_id="HBF0873484.1"
                     /translation="MEKVVSIKNASGLHARPAGMFVKKAAEFKSTVEVVAKDKTVNAK
                     SIMGIMSLGLAQGEELKLVVNGEDEEVALAAMVELVESGFGE"
     gene            36346..38058
                     /gene="ptsP"
                     /locus_tag="KNP36_001607"
     CDS             36346..38058
                     /gene="ptsP"
                     /locus_tag="KNP36_001607"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HBF0873485.1"
                     /translation="MAYKGIGASPGVALGKALVVEHSELVIEKKSIDNVEAEIAKLED
                     AVAVSKEELVKVKEKASEELGAEEAEIFEAHLLVLEDPELIGSAIDKIKTESVNAEYA
                     LNEIKEMFVSMFESMDNEYMKERAADIKDVTNRILRHILGIKVVDLSALSEEVVLIAH
                     DLTPSDTATMNKKMVLGFLTDIGGRTSHTAIMSRTLEIAAIVGLNDITSKVKDGDFVV
                     FNGDTGEVIVNPDEETINKYTELKAKYEDERKALQLLKGKPSVTLDGKHVELAGNIGT
                     PNDIEGLIKNDAEGVGLYRTEFLYMDRDSFPTEEIQYEAYKAVLEGMDGKPIVIRTLD
                     IGGDKELSYLSMEPEMNPFLGYRAIRLCLDRKDIFKTQLRALYRASVHGRLRIMFPMI
                     SSLEELLQAKEVVKEVLAELDSEGVAYAKDVEIGMMIEVPSAAVISDVLAKHVDFFSI
                     GTNDLIQYTCAVDRMNQKISYLYNQFNPAVLRLIKTVIDNAHKEGKWAGMCGESAGDQ
                     KMIPILLGMGLDEFSMSPISILPARKLITSVKESDMKKLADDVLNMGTAEEIKSYIEK
                     TFNI"
     gene            complement(38850..39515)
                     /locus_tag="KNP36_001608"
     CDS             complement(38850..39515)
                     /locus_tag="KNP36_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873486.1"
                     /translation="MKGNIVQYNFADIEEEVYSLDYAIAWNTDEENVNIIPFTNKFCK
                     ESIESFCLGKINNFVEILNEGFVENHHYVHLDKMISVPKKKVNLVYQQDTHGYLLRDD
                     NDNLIPAKITSEQSKSISSKMELFCAGEEKCLINILLKADPSYILDVDSIKDKNILNL
                     GYESIDRYKEYNFDDDKILIFFINKKRYSVIMKKTNNSDNDLVSRNNAIKELFTNKAG
                     NLN"
BASE COUNT        15791 a         4155 c         6912 g        12711 t
ORIGIN      
        1 atttcaaata atgctgtaga ttctaaactt atgaatagta ggattaaatc aatagatata
       61 ataagagggc tatcaatagc cctcatgata gtctgcaata atcctgggac ttggatgaga
      121 atgtatcctc aattaagaca tgctgtatgg catggtgtaa cacttgcaga ttttgcattt
      181 cctttttttg ttatatcttt aggtgttaca attccaatat caataaatag taaactaaaa
      241 aataataaat ccacactgag tataatactt agtatattca agagaagtat cttattgata
      301 ttatttggat ttttcttaaa ttacctagga aatcctgatt tagatactgt aagaatactt
      361 ggagtacttc aacgtatggg attagtctat tttgtgacta gtttagtata tttactacta
      421 aaaaaattaa atgttggaag tactgctaca ataattactt ttctatgtat atctacattt
      481 ataatagttg ggtactacat attagcaaaa ccttatggat ttgagctaga aggttctctt
      541 gcacagttag tggatttaca tttcttcaag ggacatttgt acaagccgga atttgaacca
      601 gatggttttt taactagtat agtagcaatt tcttcaggta tgttgggatg cactatggga
      661 tgtgtacttt taaaagaaaa cataggagaa tataaaaaat tctttaaaat actggttatg
      721 agcataatcc tgctaatagg tgcttttatc tttaatcagt attttccatt taataaaaga
      781 ttatggtcta gctcatttgt acttttaatg gctggcagtt atggtatatt actgtcaata
      841 ttttatttta tatgcgacat caaaaataaa agtaaaatat ttaccccaat aatagcactt
      901 ggaagtagcc ctatttttac atatatgtgc cttgaaatat tgagtcatgt tttttggaat
      961 gttccaaaac ttacgaacaa agtcgattat ccaactacct tggtagagtg gactacatat
     1021 gaacttataa caccttgggc aggtacaact tgggattctc ttatattttc tttattgtat
     1081 gtcctattct gggttatagt aatgtctata atgtacaaga aaaaaatatt tattaaaatt
     1141 tagtgcaata tttttagatg ataaagtctt tgatttgttc aaatatacgg aaactatcaa
     1201 atataatcaa aatttctcct cgataaaatt taaaaaccat gccataaaag attacaaaaa
     1261 gtttacaatt tgtaattttt tgtgctataa tgaaaaaaga tttacataat attgaattta
     1321 tgtaatataa aacaagctta agatgtatta aaaaagattt aaagatttaa agaaccaaaa
     1381 aattaggggg gatatgatga aaaaaacaac aaaattattg gcaacaggaa tgttgtctgt
     1441 agcaatggtg gcaccaaatg tagctttagc ggctgaaaat actactgcaa atacagaatc
     1501 taattcagat attaatataa atttacaaag aaaaagtgta gtgttaggaa gtaaatctaa
     1561 tgcaagtgta aaatttaaag aaaaattaaa tgctgattca ataacattaa attttatgtg
     1621 ttatgatatg ccacttgaag ctactttaaa ttacaatgaa aagacagatt catatgaagg
     1681 tgtaataaac tataacaaag acccagaata cttaaatgta tgggaacttc aaagcataaa
     1741 aataaatggt aaagatgaac agaaagtttt aaacaaagaa gacttagagt ctatgggatt
     1801 aaatcttaag gattatgatg ttacacaaga gtttataata agtgatgcaa attcaacaaa
     1861 agcagtaaat gaatatatga gaaaaacttc tgcaccagta aaaaaacttg ctggagctac
     1921 tagatttgaa actgctgttg agataagcaa acaaggttgg aaagatgggt ctagtaaggt
     1981 tgtaatagtt aatggagaat tagcagcaga tggaattaca gctactccac ttgcatctac
     2041 atatgacgca ccaatattac ttgcaaataa agatgatata ccagaaagta caaaagcaga
     2101 gttaaaacgt ctaaatccaa gtgatgtaat aattataggt gatgatggtt cagtttcaca
     2161 aaaggcagtg tctcaaatta aatctgctgt aaatgtaaat gtgactcgta ttggtggagt
     2221 tgatagacat gaaacatctt tacttatagc aaaagaaata gataagtatc atgatgttaa
     2281 taaaatatac atagcaaatg gatatgctgg tgaatatgat gctcttaata tttcatcaaa
     2341 agctggtgaa gaccaacaac ctataatatt agctaataaa gattctgtac cacaaggtac
     2401 atataattgg ttatcctcac aaggtttaga agaagcttat tacataggtg gtagtcaaag
     2461 tttatcatca aaaattatag accaaatatc taaaatagca aaaaatggta cttcaaaaaa
     2521 tagagtttct ggagcagata gacatgaaac aaatgcaaat gtaattaaga ctttctatcc
     2581 agataaagag ttgagtgcaa tgttagttgc aaaatctgac ataatagttg attcaataac
     2641 agcaggacct ttagcagcta aattaaaagc tccaatactt ataactccaa aaacttatgt
     2701 ttctgcatac catagtacaa acttatcaga aaaaacagca gaaacagtat atcaaattgg
     2761 tgatggaatg aaagatagtg ttataaattc tatagcatct agtttatcaa aacacaatgc
     2821 accaacagaa ccagataatt caggttcagc agcaggaaaa actgtagtga tagacccagg
     2881 tcatgggggt tctgattcag gggcaacaag tggattaaat ggtggagcac aagaaaagaa
     2941 atatactctt aatacagcat tagcaactac tgaatattta cgttcaaaag gtataaatgt
     3001 tgttatgact agagatacag ataaaacaat ggctttagga gaaagaacag cattatcaaa
     3061 tactataaag ccagatttat ttacaagtat acattacaat gcgtctaatg gatctggtaa
     3121 tggtgtggaa atttattaca aagtaaaaga taaaaatggt ggaacaacta agactgcagc
     3181 atcaaatatc ttaaaaagaa tactagaaaa atttaatatg aaaaatagag gaatcaagac
     3241 aagaacactt gataatggaa aagattacct atatgtgtta agaaataata attatccagc
     3301 aatacttgtt gaatgtgcat ttattgacaa taagagcgat atggataagt taaatactgc
     3361 agaaaaagta aaaacaatgg gaactcaaat tggaatagga atagaagata cagtaaaata
     3421 aaatagaaaa tattaaagca aaacatatca tctcctgtta taatgtaaaa tataacaaga
     3481 gatgatatat ttttgtaaag aatcaaattg tttacaatga tgtttcttgt attgataatc
     3541 tgctcattat tgagtataat atagaaataa gtcaaaaata agatagaaat aagttgaaat
     3601 taagaattaa aaaaattttt attccaatat ggaggtaact atgtctggat atactaatga
     3661 tgagtgtgaa atacctaaaa ttaaaagcta tccaggggca gataaagaaa ttgcaagtga
     3721 gattgactat agcatagtaa aaggaacagt tttattcgac ttgtaccaaa gaattatgga
     3781 tttagtttta tctataatag gacttgtgat aggtttacct ttaatagcaa tatttggaat
     3841 tcttattaaa atagaggaca aaggaccaat aacttataag caagaaagac taggaaaatg
     3901 cgggagaaga ttctatatat ataaattgag atctatgaga acagacgcag aaaaatttgg
     3961 cgcacaatgg gctgaaaaag atgatcctag aataactaag gttggaaagt ttattaggaa
     4021 aactagaatt gatgagattc cacagctgtt taatatatta aagggggaca tgggcttaat
     4081 aggtcctaga ccagagagac cgaactttac tgttcaattt aatgaggaaa tacctggatt
     4141 tatcaacagg ctcgctataa aacctgggct tacaggttgg gcacaagtaa atggtggata
     4201 cgaaatcact cctgaagaaa aacttaaaga agatatttac tatataaaaa ataggagtat
     4261 attacttgac tttaagatac tctttaaaac tgttaaagta gtattgacag gagacggagc
     4321 tagataattt taaaatatta gattactaat caatgaaaaa gctctttaaa aagagctttt
     4381 ttattgtcaa aaaatacaaa aaagaaaagg aatgagaact tatgattaaa aaaatttcta
     4441 ctatattatc gttagttttg ttaatctcta tttctagtac gataggagta tttgcagatg
     4501 caaatcccaa aagagaattg atagaaggga gtataccaga gatttcgaca gaattaaata
     4561 aaagagcatt taaggattct aaagaagtaa ttcttgtaaa tgaagagtca attgtagata
     4621 gtataagtgc aacaccttta gcatatgcaa aaaatgctcc aatagttgta actaagagta
     4681 aaaatcttgg tagagtaaca agaaattatc taaaagaact aggtccagag aaggttacga
     4741 tagtaggtgg tttaaaggca gtatctaaag atgctgaacg taatatagaa aaaatgggaa
     4801 tgaaagtaga aagaataaga gggaaagaca gatatgatac atctttaaag atagctagag
     4861 aaatgtatag aacagtagga tttgatgaag catttttact tagctcaaca acaggattag
     4921 agaacgccat atctgtatat tcttatgccg ctaaaagtgg aatgccaata atatgggcta
     4981 aagatgaagg gtttgaggaa caaattgatt tcttaaaagg caaaaatctt aaaaaaatat
     5041 atgcattagg tgattcaaaa gagtttattg cagagattga ttctaactta aaaaatatag
     5101 aaggaataaa gcaaataaat aagtcaagta caaatgttga tttaataaag aagttttatg
     5161 atgaaaaaga tataaagaaa atctatactg ctagattaga ctttggtagt agatctgatg
     5221 taaacgaata tatttctttg ggagtagtat cagcaaaaga aaatatgcca atactgattt
     5281 gtagtgataa cttaagtcgt gcacaagata aattcttgaa agatagcaat ataaatgatg
     5341 tagttgaagt tgggtataca gtaggtgatt atagtctatt taagagcata tttaatctaa
     5401 cattcttatc ttgtatagta ttaatactat tattactatt gattacattt agggcactta
     5461 gatatgagtc gaaatagttt ttgatttata aggaagcttt tcataggtta aatttactta
     5521 attagaataa tgtttataag cagttttaaa agttctactt ttagagttta aattagataa
     5581 ggagaaagaa gatgtcaaaa acagctaaag cagcattgtg gattatggca gccactatgt
     5641 tttcaaaagt attaggtttc cttagagaac ttgtacttgc aaatttctat gggacaggta
     5701 tgtatgcaga cgtatttgta ttaacattaa atatacctgg tttaatcata gcagtcatag
     5761 gctctgcagt tgctacaact tatataccta tgtactttga gacaaagaaa agactcggag
     5821 atgaaggtgc cttaaaattt actaataatg ttttaaatat atgctatata atggctatag
     5881 taatagctat tattggtctt ttatttacag agcaatttgt tacagtattt gcagcaggat
     5941 ttagaaacga ccctgctaag ttccaagcag caatattatt tactaaaata atgatttcag
     6001 gagttttatt cctgagtgga agtaagatat ttagttcgtt tttacaggtg aatgacagtt
     6061 ttgtaattcc tgggcttata ggaatcccat ataatattat aataatagca gcaatagcac
     6121 taagtgcagg taaaaatgta tggatactgc cagcaggagc actattggct atggcaagtc
     6181 agctattgtt tcaactgcca tttgcgttta agaagtccta caagtataag ccatatataa
     6241 atttaaagga tgagtccata aaagagttag tcaacctagt attgcctatg ttggtaggag
     6301 tagctgttgg acagttaaat atatttgttg accgattatt ggcaaccact ttgggtgatg
     6361 gaaagttgtc tgctcttaac tatgcaaata ggctaaatga gtttgttatg gcattatttg
     6421 ttacatctat aataacagtt atatatccta aactagcaaa aatgtctggt aaagataata
     6481 aagaaggatt tataagtact attgtaaaat cttcaaattg tattatattg gtggtgcttc
     6541 ctatatctat aggagctatt atattagcag agcctcttgt tagaatatta ttccaaaggg
     6601 gtaaatttga tgcgttatca acagacctta catctatagc gcttagatta tattcactag
     6661 gtttattggc ttgtggagta agagatgtct tatatagggc attttactct ctttcagata
     6721 caaaaacgcc aatgataaat ggaagtatag ctttaataat aaatatagtt cttaatttaa
     6781 tattgataag accattgggt catgcaggta ttgctatatc aactagtaca tcaaacataa
     6841 ttacagttat attattattt atatctctta aaaagaaaaa tggatatttt ggaggggata
     6901 aaattataaa gactggtcta aaaagtttgg tagcatctgg tgtgatggca gtagctactt
     6961 tattgatata taataatcta tatgcattta tgggttcagg aacaattaaa gaaattatat
     7021 cagttggagc tggagtatta ggtggagctt ctgtatatac tgtattgata gttttattta
     7081 aggtagaaga gatggattta gcttttgaat ttttaagaaa aggaaaacaa aaactactta
     7141 gaagatagat aattaccttg aaattttaaa ttagagtcag aaaggatgaa aatatggatt
     7201 ataagaataa ttatgagatg tggttaaatt ctccttattt tgatgaacaa acgaaaaatg
     7261 agctattaag tataaaagat gatgaaaaag aaatacaaga tagattttat aaaaatttag
     7321 agtttggaac aggtggttta agaggtataa taggagcggg aactaataga atcaatattt
     7381 atactgttag acgtgcgaca ctgggcgttt taaattatat catgaaaact caaggagaag
     7441 aaggtaagca aaagggaata gttatagcac atgatagtag atacatgtct agggagtttt
     7501 gtatagaagt agcaaagact ttaagtgctt atggtgtaaa ggcttatatt tttgaagaat
     7561 taaagcctac accagaactt tcttttgctg ttagatattt aaagtgtgct atgggaatag
     7621 taataacagc aagtcataat cctaaagaat acaatggata taaagtatat gactcagatg
     7681 gtggtcaaat ctgtatagat atggcaaatg atataatagc agaagttaat aagattgatg
     7741 attacagtac tattaaaagt atagattttg aagaagcttt atctaaaaat ttaataacta
     7801 tattagataa tgaagtagat gatgagttta taaaagctgt taagaagcaa gttttaagac
     7861 aaaatataat agatgaatac gggaaaaaat taaaaataat atatacacct attcatggta
     7921 caggaaataa gccagtaaga aaagtcttaa atgaatgtgg ctttgaaaat gtaatggtag
     7981 ttaaggagca agaattgcca gattctaatt tttcaacagt aaagtatcct aatcctgaag
     8041 aaaagtcagt gtttaatata gctattgaaa tggcaaagaa caatggcact gatttgataa
     8101 taggaacaga ccctgattgt gatagagtag gtatcgttgt aaaagattca agtggtgaat
     8161 atgtagtctt aaatggaaat caagtcggtt cacttttagt tagatatata ttagagagtt
     8221 tagttgaaga aaataaactt cctaaaaaca atcctacaat aataaaaact atagttacat
     8281 cagaactagg tgcaaaaata gcaaaggctt ataatgtaga ttgtttaaat actttaacag
     8341 gatttaaatt tataggagaa aaaataaaag cgtttgaaga aagcaatgat agaagtttta
     8401 taatgggata tgaggaaagc tatggttact taattggaac tcatgctaga gataaagatg
     8461 gtgttgtatc ttcacttatg atatgtgaaa tggcagcata ctattcttca aaaggtatga
     8521 acttgtatga agctttgata gatacatata ataaatttgg atactacaaa gaggacttaa
     8581 agtcagtaac tttaaaaggc atagatggaa taaaaaaaat aaaagagatg atgctttact
     8641 ttagaagtgt taaaatagat aatgtggctg atgtaaaagt agataaaatt ttagactata
     8701 aagatggtgt tgatgattta cctaagtcag atgtacttaa atttttactt gaagatggct
     8761 cttggatagc tataagacct tcaggtacag aacctaaaat taaattttac tttggagcaa
     8821 attcagacaa tcaagaagat gtagaattta agttgaacaa tttaatatct tatatattaa
     8881 atgtagtgga ttctatataa aaagctaagg ggagataaat aatgaaagta tacaatgtca
     8941 taatggctgg aggaggagga actcgtttct ggccacttag tagacaagaa gtacctaaac
     9001 agcttataaa tttaagtgga gaagatgctt taataaacga aactataaac agaatagatt
     9061 ctctagcaaa aaaagatgat ttatttatag taaccaatga gaagcaattg gaagctttaa
     9121 aggatatagt aaaagataaa tgtttggata gtaatatatt gccagagcca tgtgccagaa
     9181 atacagcagc agctataggt tttgcagcat ttaacataat gaaaaaatat ggtgatggtg
     9241 ttatgtgtgt atatccagct gaccattata taaaagatga aaaagaattt aaatctattt
     9301 tggaaaaagc tatctatata gcagaaaata atgataaact agtaactatt gggataactc
     9361 ctacatttcc atcaacagga tatggataca taaattttaa tagagaaaat actatagaag
     9421 atgttgcata tgaggtagtg gagtttgtag aaaaaccaaa ctatgaaatt gctaaagaat
     9481 atgtaaactc taaaaagtat gtatggaata gtggaatgtt cgtatggaag gtatctaaaa
     9541 tactagaaga ttttaagaga tacttgccaa aagtatatga aaaattagaa gatataagta
     9601 aatacttagg aacaaaagaa gaaatggaaa aaataaaaga aatataccca actatacaat
     9661 caatctctat agattatggt attatggaaa gaagtaatga tgttatagta gttcctggtg
     9721 attttggatg gaatgatgtt ggttcttggg attctctagg tgcaatatat ccaactgatg
     9781 atgaaggtaa tatcaaaaga ggtgaaaata ttactataga tactaaaaat tcaattatat
     9841 attcagatga caaattaata tcaacaatag gtattagtga tttgatagta gtatctacaa
     9901 atgatgcagt tatggtttgt agaaaagata aagctcaaga tgtcaaaaaa atagtagagc
     9961 agttaaaaga agaagataga caagaatata tgtaggaggt gttcatttga ttcctaaaaa
    10021 aatacattat gtatggtttg gtggtccaaa aggaaatata gaaaatatat gtataaattc
    10081 ttggaaagaa aagcttccag aatatgagat agtagagtgg aatgaaaaaa actttgatat
    10141 agagaaagaa ataaaaggaa ataagttttt ggaagaatgt tataaaagaa aactttgggc
    10201 attcatatct gattatacaa gaataaaagt actctatgaa caaggtggag tttatatgga
    10261 tacagatatg caaatattaa aggatataac tcctctttta gaaaataata ggctaatctg
    10321 tgggtatgaa gatgatagag agtatataaa tggtgctata ataggtgtag aaaaaggaca
    10381 tcctttttta aaagacttat tggagtatta tgaaaaagaa gtacttactt cttcattgtt
    10441 tacaatacca aagataatga ctcatcttat ggaaaagaat tataagaaga ttgacccaaa
    10501 taattatgaa gaaggaatac gtgtttacga caaagaatat ttttatcctt ttggatttaa
    10561 agaagacttt acaccagaat gtataacaga aaacactttt gggatacatt ggtggggaaa
    10621 aagttgggct aaaaagagaa attatttctt agaaagcaaa cacttaacag gtgtaaataa
    10681 gatatggaag tgttgtaaaa tatttgcaag taatacttta cgaagctaaa agggagaaag
    10741 taaaatgaag actttaaatg atgatagaaa tattatgatt agaaaatatc tttatatatt
    10801 tgttttgttt atcatattac ttagaaagta tatgatatca tttattgacc caaatatgga
    10861 tatagggatg attaaatcag cgttatttta ttcttcaata ggaatactaa tgctactttt
    10921 tttatttgac aagagaaaaa gtataacaga aatggtacta gttggagttt gtgtcttact
    10981 ttatttatta aatagggaag gagctatatt attaatcgtt ttattagctg tatcagctaa
    11041 gcaaatagat gataaattta tagttaaaaa ttatttaata atatcagcat gttttttaat
    11101 ggtagctata ttattattta atctatttcc ttcattgata tttaatcagg aagtccacta
    11161 tagatatata gaaaaaatag atatgcttgt tacaagaatg gattttggac ttggtaatcc
    11221 aaatagtgta ttttatcata tggttactat atatgcagca tatatattct taagatataa
    11281 agattataat aaatgggata gaataatttt atttggttct gcattttttg tttatcaaac
    11341 cacatatagt agaactggat ttttcactat attagcagga ttaatatttg tagaaataat
    11401 aagatggata gatataaaaa aaataaaagg actaccaatg ctcctaaaga cattaccgat
    11461 aatacttact ttatttagtg taattattgg tacagtattt gataaaagca ctttattaaa
    11521 tagattatta gcaagtagac ctaagttctg gcatgtatac ttggctgaaa aggggaattt
    11581 tctaaaacct tttggaaatt catatagtcc tgctataaaa gcaactaatc cattagatag
    11641 ttcttatgta tatataatta gtgtactagg agtagttgct tgtatattat ttatgtattt
    11701 gatgtataaa ggaatagaaa gctttataga aaaagataaa aaagcatatt tagtagcttt
    11761 atttatattt ttactatact cttttgcaga aaatttatta ttagaagctt catttagttt
    11821 tgcagtagta ttactaataa aagaagtgat attaaatgat aaaagggaaa tagatttgtg
    11881 gaagatgaaa agtaggaggt agtaatgtta atatcattaa taatgccaac attaaataga
    11941 tatgatgata tatacttact tatggacagc ttagaaaatc aaacttacaa aaactttgaa
    12001 cttatagtag tagaccaaaa tgataatagc aaagttaaag aaatagttga taaatacatt
    12061 gataagttag atataaagta tataaaaagc tctaaaaaag gattgagtta taacagaaat
    12121 gtaggcatag acaatgctgt agggcaaatt ataggtttcc ctgatgatga ttgtgtctac
    12181 gaaaatgata cattagaaaa agttataaat ttctttaata aaaataaaga ttataaaata
    12241 tacagttgca aaactatgga ttcaaataaa gttgatgcat ttaagaaaat gtatgatgga
    12301 acttgtgata tcacaagttc caacgttttg gatactataa catccataac tttttttatt
    12361 gattttgaag gtaaagacta tacaagattt gatgagaaat tgggtgttgg tggagagttt
    12421 ggtgctggtg aagagataga ttatgtttta aacttattga gtttaggttt taaaggaaaa
    12481 tactttggaa atgatataat ttaccatcct gcaaaaaaac attctaaatc taaagaaaag
    12541 tatcaaaaag attataacta tggaagaggc tttggagcgc tttgcaaaaa ggaaatagtc
    12601 tatagaaaaa attataagtt tgcaaaagtt atggtatcaa aacttgtaag aaatatagga
    12661 ggtcttatat tgagttccaa tagagattat catagtgcca ctataaaagg aagaattaat
    12721 ggatttagac agtacaagtt ataatgagga tggtgtttat ggacaaggtt aaatttttaa
    12781 taaatatgct tttggctttt tttatatatc catttaataa gcataagttt aatggtagag
    12841 atatctggct tataggtgga cattcagggg atatatacaa tgataattca aagttttttt
    12901 atgagtatat gctaaaagaa cataatgatg tagaaactta ttgggtagta aataaagaca
    12961 gtaaagtatt tgataaaatt ccaggcaaaa aattaataag aggaagtgta gaaaactatc
    13021 tgtattatta caattcaaaa gctatagtat tttcacatgc accatcagca gatatagcac
    13081 catacaattt tgctgtacct gttcttaatt attttcataa aaaaacgata aaagtgtttt
    13141 taaatcatgg gactataagt tttaaaaaaa gaaaacctat gaacaaaaag ttcaaaaata
    13201 ttatagataa cctatataaa agctataata tagttacagc aagttctgaa tttgaaagaa
    13261 atgttatggt aaatgattgg ggaatgttag atgactcagt ttatataatt ggaaatgcaa
    13321 gatatgacaa tttaccaaca aatgaagttg cacaaactcg agatatatta tatactccta
    13381 catggagaga ttggataaaa tttagttcag gaaaatttac ggatacagat tattttaaaa
    13441 atataatgaa ttttttaaat gatgacaaat taaataaaat attagatgag aaagatataa
    13501 atgtaaaaat ttatatgcat catcttatgc atgagtttat agatgatata aaagaaaata
    13561 taacaggaaa acgaattgtg tttttagata aaggggtaac tctagcaaat gaaatcagaa
    13621 aatcagctgc aaatataact gattattcaa gtgtagccat agactttttg tatatgaata
    13681 gacctatttt gttttaccaa ttcgatttgg atgaatatat ggaaaaagtt gattcatata
    13741 tagatttaaa aagtgaaatg tttgggtctt tggcttataa taatgatgaa gccgtgaata
    13801 aacttattga tattattgaa aataattttg aggttatgga taaccaaaaa aatgaaagaa
    13861 ataagttttt cagatataat gataataaga actgcaagag gatatatgat tgtgtattaa
    13921 gtaaaattaa ataaatattt tataaatgat gaggaaggta atatgaagaa gaatttagta
    13981 tctataatta ctcccatgta taattctgaa aaatttattg aagcaaccat aaaatcagta
    14041 ttaaaccaaa cttatcaaga atgggaaatg ttaattattg atgattgctc aacagataat
    14101 agtcctaata tagtcaaatc ttatatgcaa caggatagta gaataaaatg tataaagact
    14161 gagactaata agggtgtctc taatgctaga aatttagcac taagtaaggc aacaggacaa
    14221 tttatagctt ttttagatag tgatgaccaa tggaatagta gtaagttaga aaaacaagta
    14281 aattttatgt tagaaaatga ctatgtaatt tcatttactt catatgaact gatggatgaa
    14341 aatgataaaa aattaaacaa agtaataaaa gttccaccta atgtagatta tagaagatta
    14401 ttaaaaggaa atatcttagg atgtcttact gttgtgattg ataagtctaa attggatttt
    14461 gaaataagaa tgagtggtgt aagacatgaa gattatgttt tatggttatc gatattgaaa
    14521 aaagggcata ttgctcatgg aataaatgaa gttctagcat tatatagaaa atctagtaat
    14581 tccctaagtg gtaataaaat aaaagctgct atgtggactt ggaatatata tagaaatata
    14641 gaaaaaatac ctttatacaa agctatatac tactttatta attatggaat aaacggaatc
    14701 aaaaaaagtt agacagagag gaagatttaa ttaatgtata aatataaatt tactgtattt
    14761 actccgacgt ataacagagc tcatttactt gaaaatttgt acaatgattt aaaagctcaa
    14821 acttatgatt tcaatgattt tgaatggttg attgttgatg atggaagtag cgacagtact
    14881 aaagagttag ttgaaaaatt tatatcagaa aataaattaa atataagata tatatacaaa
    14941 gaaaatggag gaaaacatac tgcaataaat ctaggtgtaa aaaatgcaga tggagagcta
    15001 tttttcattg tagatagtga tgatggttta attaaagatt ctcttgaaat tgctaatgat
    15061 gagtgggatt ctttagagaa taaagaagga tttagtggag ttgttggact ttgtgtatat
    15121 ccaagtggag atttgatagg gacagaaatg cctgaagata agaaaatatg tcactttgca
    15181 gacctatatt ttaagtatgg cgttaaggga gataaaagca tagtatttgt aactgatgag
    15241 cttataaaat ttccttttcc agaaagaaaa gaagtgagat ttttaccaga aagtgtagta
    15301 tggaatgaaa tgtctaaata ctataaagtt atatgtgtaa ataaacctat gataataaga
    15361 gattatttgg atgatggttt gactaagaat atattaagta aaaatgcatt aagaggtaga
    15421 gcattagagt ttttatattt aataaatcaa aatacatatc cattaagtag atatccatat
    15481 atgtggataa aaaattacat aaatttagcc agatactcat tgttgtctga tagtcattat
    15541 tttggtgaat taagaaaagt atctgataaa ttgttgtatt tagcattatt cccattagga
    15601 tattacaaat atattggaca aagaaaatta gtatctaagt aaacttgttg gtatagtact
    15661 gctagttgct atataaggag agtaaaaata tgaatgagcc tttagtatcg ataattactc
    15721 ctgtttataa ttcagaagag tttttatcag agacgataaa gtcaatccaa aatcaaactt
    15781 ataaaaattg gcagctttta ttagtggatg attgttctaa ggacaattca agtgaaatta
    15841 taaaaagttt tcgaaaagaa gatgctagaa taaaatatat aaagcttgaa aaaaattctg
    15901 gagctgcagt atctagaaat gttggtatta agaatgcgga aggtcgattt attgcatttg
    15961 tagatagtga tgatttatgg gatagtagaa aattagagat tcagatagaa tatatgttaa
    16021 aagaaaatgt aggtttttct tttacatctt atagatatat gagacaagat gggtcaaaaa
    16081 cgaataaggt tgcaagagct cctaagaaaa ttgactatga aggattactt agaaatacta
    16141 taataggatg ttctacagtg gtcattgata aggagattgt aggagagttc agcatgcctt
    16201 tggtaagaag aggacaagat actgcaacct ggttacagtt acttaaaaag gaaaaatatg
    16261 catatgggat tcaagaagat ttagtgaatt acagattagt tggaaattct atatcaagta
    16321 acaagataaa agcattaaaa cgaacttgga atacttatag aaatgttgaa aatttaagtt
    16381 taccaaaaag tctatatgta ttttgtttct atgtttttaa tgccattaaa aaaagagtat
    16441 aagttttata tacttggagg taaaaaaatg aaaatagcta tagctgggac gggatatgta
    16501 ggtttggtta caggtgtttg tctagcagag gtaggcaatg aaaatgtagt ctgtgttgat
    16561 gtagatgaac aaaaagttaa atcaatgaaa cttggaatag cacctatata tgaagaaggc
    16621 ctagaagaac ttatggttaa aaattacaac agaggaagaa tagattacac tacagactat
    16681 aaaaaagctt atgaagatgt agatgtaata ttaatagctg taggtacacc tgagagaagt
    16741 gatggttcag ccaacctaga ttatataaag gcagttgcaa agcaaatagc tgaaactgtg
    16801 acaaaagata ctctagtagt aataaaatct acagttccaa ttggtacaaa tgaagagata
    16861 gaagattata taaatagaaa cctaaaaaat gatgtaaaag tagaacttgc atctaatcca
    16921 gagtttttat cacaaggaac agcagtaaaa gatactctac atgcttcaag aatcgttata
    16981 ggtgtagaaa gtgaatgggc tagagaaata ttagaggaaa tctataagcc ttttaatcaa
    17041 cctataatag ttacaaatag aaatagtgct gagatgataa aatacgcatc aaataacttc
    17101 ttagctctta aaatatcatt tatgaatgat attgcaaatc tttgtgaaat agcaggagct
    17161 aacatagaag atgtagcttt aggaatgagt tatgatgata gaataggaag taagttttta
    17221 aaggcgggaa taggatatgg tggttcttgc tttccaaaag acacaaaagc tcttcactgg
    17281 ttatctgaac ataatggtta tgaattaaaa acagtaaaag ctgcaataga agttaatgaa
    17341 agtcaaaaac ttaaattagt tagaaaggca tctaagttag tagagagctt tcaagatatg
    17401 aaggttgctg ttttaggttt gacttttaag ccagacactg atgatataag agaagcacca
    17461 tctataccaa atataaaata tttgctcgaa agaggggcaa gagttactgt atacgaccca
    17521 attggtgtaa ataatactaa gaaaatattt ggtgactcta tactttatgc tgattctgta
    17581 gatgatgcga tagaagatgc agagatatgt tttataatga cagaatggaa agatgtatta
    17641 aattatgata tacataagta taaggaaaag atgaaaaatc ctttagtcct tgatggaaga
    17701 aattgttata aaattaaaga tatggaagag ttaggaattg agtattattc gataggaagg
    17761 taaatattat gaagactgtt tgttatttag ctgatgggtc aaatcctcat actttaaaat
    17821 ggtgtagttt ttttaaaaat aaaggatatg acattcatgt aatctcttta aatggaggtc
    17881 acatggaagg aataaaaatt tataattttg gttctaatgt agaagaacta aaaaatgaaa
    17941 atatttctaa aaaaacggga tacttaggtt caataaagca gataaagaag ctagtaaatg
    18001 aaataaagcc agatatattg catgcacagt atgcaagtag ttatggattt ataggaagtc
    18061 tacttgggta tcatccatat attatttctg tttggggtac tgatatttat gatttcccta
    18121 ataatggttt tatacaaaaa caaattataa aacataactt tagaaaagca gactatatct
    18181 tttcaaatag tagagatatg gctaaagagg ctaataaata tacagctaaa catgtagatg
    18241 taaccttttt tggagtagat atggataggt ttaagcctat ggaagtagaa aaagaagacg
    18301 cttttgtaat aggaattata aagagtttag aaaaaaaata tggaatagaa tatttaatac
    18361 aagcatttaa gatgcttaaa gatgaatata aagataagaa aataattctt aaaataggtg
    18421 gctctggaag tcagatggac aacctaataa atttagctaa agaattgggt atagaaaatg
    18481 atgttcagtt tttaggaaga atatctccag aaaatgtaag caagactttt aattcttttg
    18541 atgtaactgt atttccttct ttaagagagg gatttggagt ggcagctata gaatcagaag
    18601 catgtgaagt acctgttata gttacaaatg taggaggaca tccagaatct gtatgggaaa
    18661 atgaaactgg cttaattgta gaaccaaaac aaccagaaga aataaaaaat gctataataa
    18721 aactaatgga aaatgatgaa cttagactta atatgggtaa gaaagggcgt caatttgtta
    18781 gagaaaatta tgaggttaat ttaaacttta atgatataga aaaaatttat gattctatat
    18841 ttgataaata taaaaaataa aatgaaaaaa tacagcaaaa gatagatgtt gttggctatg
    18901 cttaggtgcg tagcttttgc tgtttaaagg agggcttcta gttatgcgag aaagtataga
    18961 tttagagaaa gaaagctttt ttaataggct ttttaaaaaa tataaattta gacatttaac
    19021 actattaatt ctagatattt gtagcgtact agtagcgttt cgaatgtctt taagcttgac
    19081 aggtaattta aatgcattta ccactaatga tataataatt tcagcgtgta tatatatagt
    19141 acttcatata gtatcattta gattgtttaa gtgctacaac acattatgga gatatgcagg
    19201 agaagaagaa attatatcta tttttgtggc aactttagct tatttaattc cgatttatat
    19261 aataaataaa ttattagggt ttgattatcc tataatgttt tatgtattaa atacaatatt
    19321 tattataatg tttacaagtg gcgcaagaat agcctataga gctataagaa tagtcatgaa
    19381 caagacatat tctagaggaa aggtttcaaa tatccttata attggtgcag gagatgcagg
    19441 agaaatggtt atacaggaac taaaaagaaa tccagaactt aaaaaagtag cagtggctat
    19501 aattgatgat gataaaaata aaattggaag aataatccac aatgtgaaaa ttgtaggaac
    19561 aacttcagat ataaaagatg tggtagaaaa gtacaatgta gatgagataa tcttttcaat
    19621 agcaaacata gagaaacgta gaaaaaaaga gattattgat atatgtaaaa acactaactg
    19681 taaaataaag acaataccag gaatttacga aattatagat ggaaaagttg atataaaaca
    19741 gattagagaa gtagagatag aagacttgtt gggtagagag cctataaaaa caaatttaag
    19801 agagataagt aattacattg agggaaaagt aatcctaata actggaggag gaggctcaat
    19861 tggttcagag ctttgcagac agattgcagg atttaatcct aaagagctta ttatagttga
    19921 taattatgaa aataatgctt actcaataca acaagaattg cttagaaaat ataaaaataa
    19981 attagattta aaaacagtaa tagcatcaat aagagaagaa aaaagaatgg atgaaatatt
    20041 taataaatat aaaccagaag tggtatttca tgcagcagca cataaacatg ttcctcttat
    20101 ggaatcgagc cctggcgaag ctataaagaa taatatattt ggaactttaa acatagctgg
    20161 cttgtcttca aaatatagag ctaagaaatt tgtccttata tctacagata aggctgtaaa
    20221 ccctactaac ataatgggag ctactaaaag agctgctgaa atgattatac agactatgaa
    20281 tgctgaaagc cagactgaat ttgttgctgt tagatttgga aatgtgcttg gtagtaatgg
    20341 tagtgtaatt ccacttttta agaagcaaat tgaagatggc ggaccagtga cagttactca
    20401 tccagatatt attagatatt ttatgacaat accagaagca gtaggcttag ttatacaagc
    20461 tggggctatg gctaaaggtg gagaaatatt tgtacttgat atgggagaac ctgtaagaat
    20521 attggattta gcaaaaaact taattaaatt cagtggattt gagccagatg ttgatataaa
    20581 aattgaattt tctggtctta gaccaggaga aaagttgtat gaagaactac ttatgtcaga
    20641 agaaggtctg ttggatacag agcataaaaa gatttttatt ggtagaccaa tagatgttga
    20701 tagagaaaaa ataacaaaat acttaaaact tttaagagaa attactaaca atgaagaggt
    20761 tgaaaaaata gatggtatta tgagggaatt agtgccaact tatattaaac cagaagatgc
    20821 taatatcaaa gaaattgcaa caactagaga aaagtagaat atatttctaa tttgtaacca
    20881 gggggagcaa aaagaaacaa atatatacta aaaagaaaca aaagattaca aaaagattac
    20941 aaaaagatta caaaaaaggt tgcaatttat tttgatgtaa gatagaatgt taattaggaa
    21001 ttggaaacga aggaacaaaa tgttaaattt tcgaaaggat taggtatttg agattatgat
    21061 gaatattaaa aataaaaaac atatattgaa aaaatttata gctatggtgt taatagcagg
    21121 agttgtcaca gtagaagcag gagcaataac ggctagtgca gcagagccaa ctaattcacc
    21181 tatgagtgca acagtagacc agtgtgattt tttaaatgta agaagtggag ctagtgcaaa
    21241 tgatgcagta gtaggaaaga taaacacagg agacaaagtt gaagttttag aattacattc
    21301 aaatggatgg attaaaataa aaagtgttga caatgttaca ggatgggtaa atggagatta
    21361 tttaactatt caaggtggaa atgtagatgc aaaggtacaa aatgttttaa acttagcatt
    21421 taagcaacaa ggtaagccat ataaatgggg agcaactgga ccaaattctt ttgattgttc
    21481 tgggttcact tcttatgtct ataaaaatgg agcaggagtt aatttaccaa gagtatcaag
    21541 atcacaagca acagtaggaa agaaagtatc aagagcagaa ttaaaaccag gagatttagt
    21601 tttctttggt tcaggtggtt caataaatca cgttggattg tatgtaggag attctaaatt
    21661 catacattca ccacaaacag gagatgtagt aaaagttact agcatggctc caggaactaa
    21721 ttatgcaaga agacttataa ctgctacacg tgttttacaa taataataga tattgattta
    21781 cataggattg aatattaaca ttaaatatat aattacattt aatgttttac atagagattt
    21841 aagagtttag taatattaaa atagtgatga acgttataaa aacagcaaag aagataaatt
    21901 tctttgctgt tttttttata ataaattatt tcatattata atcaaatatc aaatataaat
    21961 tttaactata ttattcaata tttgacagat aatatgaatt ttagatatac ttaataagaa
    22021 gtatattgta gaaaaaataa atttaaaaaa ttaaggggga tgaaatgaaa aaaataagta
    22081 tattagtatt atcattgata atgacactta ctatgtgtag tgtaagttca tttgctgatt
    22141 catcaaatga taaggaaatg agagctgctt ggatatctac agtttataat ttagactggc
    22201 ctaagactaa gaataatgaa gccaagcaaa aaaaggaata cacagattta ttggacaaat
    22261 taaaaagtgt aggaataaat acagcagtgg ttcaagtaag accaaaatca gatgctttat
    22321 ataaatcaaa tataaaccca tggtctgaat atcttaccgg tacacaaggt aaagaccctg
    22381 gatatgaccc attaccattt ttaatagaag aagcacataa aagaggaatg gaatttcatg
    22441 catggtttaa tccatataga ataactatgg cagatgagag catagataaa ttgccagcaa
    22501 accatccagc aaagaaaaat ccaagctggg tagttaaaca tggaaataag tattactacg
    22561 acccaggttt accagaagtt agaaagtaca tagtggatag tatagcagaa gtagttcaaa
    22621 attacgatat agatggagtt cattttgatg attacttcta tccaggagta agtttcaatg
    22681 atactgcaac ataccaaaaa tatggaaaag gacaaaataa ggatgattgg agaagagaaa
    22741 atgtaaatac tctacttaga gatgtaaaag cgtctataaa gagtataaag cctaatgttg
    22801 tatttggtgt aagcccagca ggtatatgga gaaataagag tagtgaccca acaggttcag
    22861 atacatcagg taatgaaagt tatgtaggta catatgcaga tacaagagca tggataaaac
    22921 aaggattgat tgactatgta gttccacaac tttactggcc aattggtctt aaagcagcag
    22981 attattctaa attagtggca tggtgggcta atgaagtaaa aggaacaaat gtagacttat
    23041 acataggaca aggtatatat aagcaaggtc aatcgagtta tggtggacaa aatatagcaa
    23101 aagaaatagt acaacaagta acattaaata gaaagtatag tgaaataaaa ggtagtatgt
    23161 atttctcagc taaagatata gcaaatagta cttctataca aaaggattta aagagtttat
    23221 attctagtag tgaagaacca gttactccac catctaatgt taaagtggag aaattaagag
    23281 gcgacgaaag atatgacaca gcagtagcaa taagtaaaaa aggttgggct acaaattcag
    23341 atacagtagt attagtaaat gggtactcta tagttgatgg tataacatca acaccacttg
    23401 ctacatcaaa tgatgctcct atactattgg taaataagga taatatacct acatccacta
    23461 agaatgagtt aaaaagactt aatccaagta aagttatttt aattggagga aataactcta
    23521 ttggagataa agttgagagt gagataaaag atacattgtc aaatgtatca ataaatagag
    23581 ttggtggttc agatagatat agtacatctt taatgatagc aaaagaatta gtaaaaacta
    23641 atccagtaga aaaactatat ataacaagtg gtacaggtga agcagattct ctttctatag
    23701 cttcaaaagc aggagaagaa aagcaaccaa tagtattagt atcaaaagat aatgtaagtg
    23761 atgaagttta caattggata tcagatttga aagtaaaaga tgcttatttt ataggtggta
    23821 atctaagtat atctgattca gtaataaata agctggataa ggtcattaca aatgatgtat
    23881 ctaaaaatag aatagctgga gaaaatagag aagaaacaaa tggaaaagta atacaaaaat
    23941 tctatccaaa tgctgaatat tcatcaatgt ttgtaagtaa aagtaatcaa ttggtagatg
    24001 cattaacatc aggtccttta gcagctaaat taaaatcacc agtagttatg cttggaaata
    24061 gtgtaacatc tgctcagaaa actgctttag agcctaagaa aactactcta gtatacgaag
    24121 ctggagatgg tataaatcaa aacacattaa acactttctt aaacttagtt aagtaataaa
    24181 aaagttaatt taaaatacag agtattttat aaatgtagat taaaatgaaa attatcatga
    24241 taaattagaa aataaaaaag aactatatgc attttgtaat caagtgtaca cagcaacttg
    24301 aaaataatta tgcgatatag ttctttttta gtaattaatc ttatactttt taataaactt
    24361 tatgttgaat tttttattgt ttaaactcta tgtcattaaa tataaaatcg tgtaatatgt
    24421 ctaaagtatc tgggtcaaat ctaagaaccc atccagcttt tccatatata ccacctgtac
    24481 tatgaatttc atcatcaata ggaaattcaa attgcttaat atttaagtcg cccattttta
    24541 aaacttgagc tcctaaagaa agtattgcat taggcttcat gttagtttta acatatggaa
    24601 gaactgcatc taataaacct ggatatttag taacaggtaa agtttccgtt ttcttgatta
    24661 tagcttgtat aatctgtctc tgtctgccat ctctagcaaa ggctgtatcg ttgtgtctga
    24721 tacgtgcaaa agatagtgcc tgatatccat ttagagtctg ctttccagag tttctaatgt
    24781 attgtatgct acctttatca tcacttttat tccatttata agtttcagga ataaatttat
    24841 ttagttctcg tatttctcct ttttcaacag taacctcaac gccaccaata gcatcaatta
    24901 tatacataaa tgattcgaaa ttaacacaag cataattttg aatatcaata ttaaaattct
    24961 cttcaattgt ttgtattaat aaatcagctt gtccataagc ataagcatga gtaagttttt
    25021 gtttaccatg accagggatg tctacatagc tatcacgagc taatgatgta agtttgatat
    25081 cattgtgttt gttatcaata gtaagtatca tcatagcatc tgaccttgaa gaatcttcat
    25141 ttggtctagc atctgttccc ataagtagta tgttaattat cccatcttca tttttatggt
    25201 cattgttatc caataaatca ctacttatgc tcgagtcatg aatagcagat aatttataat
    25261 aaaaatatcc atagacactt atagggaata ttactaccaa gaaagccagt agtataacaa
    25321 atttctttaa ttttgacaaa agtacccctt ctttcttctt tttcctgtat attttttaat
    25381 agcatacact taattatatt aaagtattga gatatattca atacttgttt cagttacaaa
    25441 aaaaagacaa tgatataatt tataagaaaa tttatcgacc tatatatata gttaaaagta
    25501 tatataatat attttttaaa agtaatttat attttaaaat aaaaacacac cccataaata
    25561 caaagtaatt tgcatttaag aggtatgtat ttatcatcaa attattggtt tgttttggaa
    25621 tttctaatct tcaaccataa tatctttaaa tatgaaatca tgcattgcat ctagttcata
    25681 ttcctcaaaa ggtattacat agcctgcatt acctattttt ctaccatttt cagtagaaag
    25741 aggaaactcc atagatttca aatttaaatt tcctatactt aaaagttctt ttcctaaaga
    25801 tattatttca ttaggattca tattagtttt tacatacgga agtattgtgt taactagatt
    25861 aggatattta gtgactggta aatccttaac accatttatt aaactctgta taacacttct
    25921 ttgtcttcta tctctttcat ctgtactatc attttttctt atacgagaaa atgcaagtgt
    25981 ctgatatcca tttaattttt gctcaccaga atttcttata tatttaagag aacctttatt
    26041 gtcattttta ttccatttat aagtttcagg aataaattta tttaattctc ttatttcact
    26101 cttatcaaca gtaacagtaa ctccacctaa agcatcaact atatccataa aagagaaaaa
    26161 gtcaactacg gcgtagtttt gtatatcaag ttggaagttt tcttctatag tttctattaa
    26221 taagttagct tgtccatata cgtaggcatg tgttaatttt tgttctccac gtcctggtat
    26281 attaacataa gtatctctat ttaatgaagt tagcttaaga cttttatttt tattatcaat
    26341 agtaagtatc atcatggcat cagaacgaga aacttcttct cctggtcttg catctgtacc
    26401 taacaataat atgtttgtga tattttcttc gtttttatag tcattactac taagcgcctc
    26461 tgtatttata ctatcatctt gtatagtttt taatttagta aaaacatatc catatatact
    26521 aacaggaaat gctataacta aaagggctag aaatataacg aactttttga gtcctgacaa
    26581 taatatcccc tactttctaa attttttaat tacacatagt taattatatt aaaaatttgt
    26641 tacataagca ataaaaaaca caataaatta gcataagttt gtcataatat aattattttt
    26701 atagcatttt atagaagaaa gtgtgtagtt attattgatt ttattggaat ataattgtat
    26761 gaagacttaa atttttataa actgatgtgt atattgaaaa aaatattttc ctgaatgtag
    26821 ttatagcatc ttatgaaagg tgcaaattgt aatttaaaat ttttagtgta taataagaat
    26881 tgaaaattca aaccgataaa aattaataaa aaataattat aaattaataa tttgggggag
    26941 gaaatgtatg ataaaattaa tagcaacaga tttagatgga actttgttag atgaaaagag
    27001 cgaaataaat ccagagtttt ataaagtatt taaaaaatta agagagagag ggataatgtt
    27061 ttctgctgct agtggcaggc agtatcaaaa tcttataaaa aaatttgaag atataaaaga
    27121 tgatatgatg tttatatcag aaaatggaac actagtagta tataaaggaa aagaaatatt
    27181 atcaaatcct ttaaataaag aattagtaaa tgaaatcata gagacaacaa gaagtataaa
    27241 agggaaaaaa attgtaatga gtgggaaaaa atacgcttat atagaaagca aagatgaagc
    27301 gtttatacaa gaggtcagta cttattatgc aaagtttaaa attgtagaag atttgacgaa
    27361 agtagaagga gacatattga agatagctgt atttgacttc aaaggtgcag aacataataa
    27421 taatatctac tttgaaaagt tttctgatag agctcaagta tgtatttctg gagtggagtg
    27481 gcttgattta actgcaaaag gtgcaaataa agggagtgcc ataaaaaaag tacaaaaaat
    27541 gttagatata aaatatgaag aaactatggt atttggtgac cagttaaatg atgtggaaat
    27601 gatgaaaagt gcctatcata gttatgccat ggaaaatgca aatgaacatt tgaaacaaat
    27661 tgctagattt agagcaaaaa gaaatactga aaatggcgtt gtagataaga taaaagaggt
    27721 tataaaaatt ggatagtcat atgtatagat gaaaaagatt attttgaaga aatcaaaaaa
    27781 atatcaatgt aattttgata aataagttta tttatgcgaa aattacattg atatttaata
    27841 aacatcaata atagatattt atttttttat gatattcagt attttgtttt ctatttgagt
    27901 tgcattttca gcagaaatta aataaacata tctacctgcc ttctcaatta tagtattatt
    27961 tgctatttca gaattgattt tttctccatg tccttctcca aaaggtgctt gtatcatatc
    28021 ttttttataa ttttctagag ttttatagat tttatctacc tcgtcagttt ttataacgat
    28081 aatatcttct agagataatt tttcagaaga attaattaca aaaccttgaa ttatgtcttc
    28141 ctctacatca ttaaaatagt taaaatcctt tgcatcaaag atttttgatt cctttataag
    28201 taaatcagaa gattttaatg ctttttttat ttttgatgta gaaacgtttt tgtaatcacc
    28261 acttgaagaa caactaacca ttcctaatga taagattatc gaaaaaaaca atattaaaat
    28321 ttttttcatg ataaacctcc aagtttttta aactctgtct taaattagtt tactacataa
    28381 ttatataaaa ataaatgtat ttaatgttac agttttgatt aataatgtaa tattttgata
    28441 ataataccta ttgagaggtg attagaaatg agaataccaa aacatgtagg aattataccg
    28501 gatggaaata gaaggtgggc aagtcaaaat ggtatgacaa aagataaagg atatgaaagt
    28561 ggaatagacc ctggactaga gtcttataga ttatgtagag atttaggctg tgaagaggtg
    28621 actttttatg gatttacaac tgataataca agacgtccat cagtgcagac aaaagctttt
    28681 acaaaagcat gtattgatgc tgcaaatata ttaatagatg aaggtgctgc tttattagtt
    28741 gtaggaaata caaaatctcc aatgtttcca gaagaattat taccatatac taatagaatt
    28801 aaagccaaag aaggtcaaat aaaagcaaat cttctggtaa attatggttg gtattgggac
    28861 ttaaataata tatcaggagt agaaaatgta aataaaaata atatacagga ttacatacag
    28921 tcatttgatg tatccagact agacttgata atcagatggg gtggaagaag gagattaagt
    28981 ggtttccttc ctgtacaatc aatttatgca gatttttatg ttatagataa ttattggcca
    29041 gattttaaga gtgacgatat aaaggacgca tttagttggt atgatacaca agatgtcact
    29101 ttaggtggat aattaaaaat attctgattt aaggttgtag agtgttttaa attattgaaa
    29161 aaaaaacttc ttgatggtaa aataacacta ataatatgta aaagtgtaaa aatttatacc
    29221 aagaagggtg aagaaatgtc aaaaggcaat aataacaata attcaagaaa caaatctaaa
    29281 aagaccagtc atctgaatag aaaaaagcga aaattaaata agaaaaagtt agcagtgttg
    29341 atttgcttta cagttttatt tttatttatt gcatttaagg ctactcaagg tgtagtagct
    29401 ttggtaaaaa gtatggataa aagtaataaa actaatcaac aacaaaatgt taactcagaa
    29461 caatttgacc ttggtaatga agaggaaaat aaaaagaaaa aatatactgt atttatagac
    29521 ccaggtcatg gaggcaatga taaaggaact gaaagcaaga ccagtaatag atatgaaaaa
    29581 gacctaaatc tacaaattgc aaaaaaatta gcaaataaat tatctaaaca aaaggatatt
    29641 caagtagtag tatccagaac tgatgataca tatatatcat taaaggatag agctatctta
    29701 gcaaataata gttctgctga tgtgcttgtt tctattcatt taaatgcaga gaaaaatggt
    29761 aatacagcaa caggtataga aacttggtat aggaataaag ctacagatgg ttcaaaagaa
    29821 cttgcacaga cagtacaaag tactatagta tcctatgtta aagttagaga taggggaata
    29881 gttgaaaata actttgaagt acttagagaa tcaaatatgc ctgctatatt aatagagtgt
    29941 ggttttttaa caacaccttc agaggaacaa aaaataataa atgaaaaata tcaagaccaa
    30001 cttgcggaag gaattgttca aggtgtactt tcatacctag attctaaagg gaataagtaa
    30061 gttaacttta ctttaatgtg aggataaatt taaaagttta actgtgtaaa ttgtattaac
    30121 tttatttcgt aatgttgcaa acattgtttg aatttagaaa ctatgaaatt agaaattatt
    30181 ttatctatat ctaatttcat agtttttttt gcaaaaaatt tatagttata aaattttaaa
    30241 aaataaattt agtataatgt aatgtagtta tttatatgtg attttaactt gcattgattt
    30301 gctatcaatt gtgctttata attagtatat ataaagttta actgtaagat aatttaaaaa
    30361 ataggggaat ttatatgaat aaaaatagca tgacaagaat ttacagttta aataaaataa
    30421 tttttattat aattggaatt ttaggaatag ttttactcac aagacatatt gaggtagata
    30481 ttaaagtttt aattttaatt ttattaacct tgtttagtat aaatgtattt atttcatatc
    30541 ttaaaattaa gttgtatgag gataaaatta atttaggatt gataaataat tcagataagt
    30601 ttataaatat tactaaagat gagaacttcc taaaacatgt tcaaaattat attatcagta
    30661 atgaaaaaga aaactgtgta atggcttgtt ttgatttatg tagactcaaa cttataaatg
    30721 atatatatgg ttatgagcta ggggatgaag tgttaaataa tattttaagt aacttaaaaa
    30781 attattttgg aaaagaagct atttatggaa agttaaaaag tgatgttttt gtattaataa
    30841 taaagcttga aaatagggaa cagaagattc cttatttagt aaatcttatt aagaataaaa
    30901 ttgtgatact aagtcagatt gacagtttta aaatggatat aaatattgag gcttctattg
    30961 gaatttataa atttaacaat aatgaaattg atataaaaaa agctatagat aatgctgata
    31021 tggcaagact taaatcaaaa ggactaaagc acatagagta tgtagaattt gataatgcta
    31081 tggaagaaga aatacaatca attatgaaaa tagagagaga tttattcttg gctattaaaa
    31141 ataaagagtt tgtaattcac tatcaaccta aagttgattc aagtacaggt aacattatag
    31201 gttcagaggc attgataaga tggttgcacc catcattagg catggttgga ccaaataagt
    31261 ttatacctat agctgaaaaa aatggtctga taaacaatat tggtagatgg ctaattcaag
    31321 aagtttttat taccattaac aagtggattt cagaaggtat aaatgtctta ccagtctcaa
    31381 taaatctttc tagagtagaa ctatataaaa atgatttagt tgattttttt aaactgatgt
    31441 ttaatacata taatattcca aaagaactta tagaattaga aattacagaa acgacagcac
    31501 taagagatgt aaaatttata agtgaaaggc tttatgagat taaatcttta ggtatgaata
    31561 tatcattaga tgattttgga gtaggtaatt caaattttat caaccttaag gggataccac
    31621 tagatattat aaaaattgat aggtcactta tattggatat agttacaaat acaaaaacaa
    31681 agtttatggt gaaagcaatt gttaaccttt cacatgattt aaacgtaact gttatatgtg
    31741 aaggggtaga ggatatgcat caggtcaaag tcttaagtga actgggatgt aatttcatac
    31801 aaggttatgt attttttaaa cctttggatg agatgaatta taaaaaactt cttactgacg
    31861 gaagttatat aaatctgaaa gatactcttt tagataaatg catgacagtt gaggaggagt
    31921 aaggatgatt tcagaagatg tagattattc aataagaatc ataagagcta tatttaataa
    31981 tggagaagat aaaccaatag atgctaaaat gatattaaaa agtgaagata taccaatact
    32041 aacactatac agactgctta gaaagctttg tgcaaacaat attcttactt ttaacaaaga
    32101 agatggcaag acatacatgt taaatgtgtc attggataca ataagtctaa gaactattgt
    32161 agaagtaatt gatggaaaaa tatatataaa taaatgtacg agatatgtat ctaattgcag
    32221 taattgctta aaaggttgta aagtaaatcg tgaattgcta gaaatagaaa aagaaattta
    32281 taaactttta tcgagaaaat ctataagaca aatactagaa taaaaaattt tcagctatga
    32341 taataattgg aggttttcgg ttatggatga tatatctcaa gataattttc tactgtctaa
    32401 agagtatgag aatagcttag atgtagatac taaaaaagca agtggaatat attatactcc
    32461 taaaataatt gtagattata ttgtaaaaaa aactttaaaa aatcacgata taattaaaaa
    32521 tccatatcca cgaatacttg atatttcctg tgggtgtgga aattttcttt tagaagtata
    32581 tgatatttta tatgacttat ttgaggaaaa tatatatgaa ttgaaaaaga agtatgatga
    32641 aaattattgg actgttgata acatacaccg tcatatatta aactattgta tatatggtgc
    32701 tgatattgat gaaaaagcta taagtatatt aaaagatagc ttaacaaata aaaaggtagt
    32761 aaatgattta gatgaatctg atataaagat taatctattt tgttgtgata gtcttaaaaa
    32821 gaaatggcga tataagtttg attacatagt gggtaatcca ccctatattg gtcataaaaa
    32881 acttgaaaag aaatataaaa aatttctcct agaaaaatat agtgaagttt ataaggataa
    32941 agctgactta tatttttgtt tttataaaaa gattatagat attttaaagc aaggagggat
    33001 tggcagtgtt ataactccaa gatatttttt agaaagtcta tcaggtaaag atttaagaga
    33061 atatattaaa tcaaatgtca atgttcaaga aatagtggat tttttaggtg caaatatatt
    33121 taaaaatata ggggtatcta gttgtattct aacttttgat aagaaaaaaa caaaagagac
    33181 atatatagat gtatttaaaa tcaaaaatga ggatatatgt ataaataaat ttgaaacatt
    33241 ggaagaactt ctaaagagta gcaaatttga acattttaat ataaatcaga gattgctatc
    33301 tgacgaatgg atacttgtaa ataaagatga tgaaactttt tataataaga tacaagaaaa
    33361 atgtaaatat agcttggaag atatagcaat aagttttcaa ggaataatta cagggtgtga
    33421 taaagcgttt attttaagta aagatgatgt aaagttgaac cttgtagatg ataaattttt
    33481 aaaatgttgg ataaaaagta agaatataaa taaatatata gtagataaaa gtgaatatag
    33541 gctaatatac tcaaatgata tagataatga gaatacaaat aaaaggatac tagatgaaat
    33601 tatagggcta tataaaacaa aattagaaaa cagaagagaa tgtaaaagtg gaataaggaa
    33661 atggtatgaa cttcaatggg gtagagaaaa gcttttcttt gaaagaaaaa agataatgta
    33721 tccttataaa tcaaatgaaa atagatttgc tatagattat gataataatt tttcaagtgc
    33781 agatgtatat tcttttttta taaaagaaga gtatttagat aaattttcat atgaatatct
    33841 agttggaatt ttaaattcca gtgtttatga taaatacttt aaaataactg ctaaaaaaat
    33901 gagtaaaaat atatatgatt actatcctaa taaggttatg aagataagga tttttagaga
    33961 taataattat gaagagatag agaatttatc aaagcaaata atatcaattt tattaaataa
    34021 gtctatagat aaaggaaaag tagaaaaatt gcagataaaa atggataact tgataatgga
    34081 ttctttaggt atataagcag ttgtaagtat taaaaaatta taatctttta attgtttatt
    34141 taaatttaga aataaaaagt tagccatata aaaaatatta aaaatatata cttttcaata
    34201 tttttttgat aaaataagaa tgaatttgtg caattttatt tttctccaat aactaaaaat
    34261 agttttttga attaatattt gcttaagaat aaaaatcaga aacgtttttg atatagtagg
    34321 tgataatatg aaaggattag ttttagaagg tggaggaaca aaaggagcct accaaatagg
    34381 tgcatataaa gctttaagag agcttggtat agagtttcaa ggagtaactg gcacatcaat
    34441 tggtgcttta aatggagcat atatagttca aaatgatatt gaagtaatgg aagatatttg
    34501 gttaaattat gactatactc attttatgaa tattgataga gaaacctatg agaggtttaa
    34561 aaatgtagat ttcactacta aaaatctcaa tgcagtgttt gagcttataa ataaagctag
    34621 aaaaaatgaa ggtatagata taagcccatt aagacaacta atggagacaa cattaaatga
    34681 agacataata aggaaatcaa aaaaagactt tggacttgtt acggtctggt gggataaaaa
    34741 aattaatcca tatccattgt atatcgaaga tatacctaaa ggaagattga ttgattattt
    34801 aattgctagt tccagtttgc ctatttttca aacgaacatg atggatgata agttgtatct
    34861 tgatggaatg ttttgtgata acatgccaat aggactcttg gaagacaaag gttatgaaga
    34921 tgttgttgta attaggttga ttgatgattt tattgggaaa atgaatctaa atcgacatca
    34981 aaatataaat ataaaaacta taataccatc agaatatcta ggaggttctc ttaataaaga
    35041 tagagataat gtagaaaaaa acatccgact aggttactta gatactatga aagcatatga
    35101 aagatgcact ggaattaagt attattttga tgtagagtat aaatataatg aagaatattg
    35161 ttttgataaa tttagaagta tgagcaatga aacaatacaa tatatctgta atttattgaa
    35221 tataaaaaga gatgcttcac ttagaaccgt tatggaaagt gtaataccaa agcttggtga
    35281 ggtgcttgga ttgccaaagg atttttcata taaagatttg ttttactgta tatatgaaaa
    35341 gaaacttgaa gaaaataata taaacaggat aaaattatat gattttaaca aggttataga
    35401 tgttgtaaat acaaatattg attctaatag aaatttagct tctaattttg aagttagacc
    35461 taaaattagt attaaaaaga acaaaaacac aaaattattg acaaattgta ttataaaaga
    35521 cataaaaaat caaagttaaa taaaaaacaa aaaaaaattt gtaattatac tcgaaaaaag
    35581 tgtatattag tagtataata tttttgtagc actagtggga acaaaaaatg accataggac
    35641 aaaaaagtac cacttagtac cattaaagta aaaaacagga aaacaatttt aaaaaatata
    35701 aaatgtaaag tttataggag gatttaaaaa aatggaaaaa gtagttagta tcaaaaatgc
    35761 aagtggatta catgctagac cagcaggaat gtttgttaag aaggcagctg aatttaaatc
    35821 aacagtagag gttgtagcaa aagacaaaac tgtaaatgca aaatcaataa tgggaataat
    35881 gagtttaggt ttagctcaag gagaagaatt aaagttagtt gtaaatggag aagatgaaga
    35941 agtagcttta gctgcaatgg ttgaattagt tgaaagtgga tttggagaat agatataata
    36001 attttttaaa aatttgatat ttagaatcta atattactta aagtaaagta acagagaagt
    36061 attaaacata tacagaccaa catttgtaga tatttaattt ctttgttact ttcatgttta
    36121 tttaatcaga agattaagac tattgttaat tgggtataaa aatataaata ttttagaaaa
    36181 tgaaataaga tatttttaat cataaattca gagtaaaaat acagtaacaa atagtttata
    36241 aaattttata aaaaattata agtaaataaa actataaaaa tgtaaattat ttatataaat
    36301 ttataaagtt tatgtgctag atgatatttt ttaggaggta gggttatggc ttacaaagga
    36361 ataggtgctt ctcctggtgt tgctttaggg aaagcgttag tagttgaaca tagtgaatta
    36421 gtaattgaaa aaaaatctat agataatgtt gaagctgaaa ttgctaaatt agaagatgca
    36481 gttgcagttt ctaaagaaga attagtaaaa gttaaggaaa aggcttctga agaattagga
    36541 gcagaggaag cagaaatatt tgaagcacat ttattagttt tagaagaccc agagttaatt
    36601 ggttctgcaa tagataaaat taaaactgaa agtgtaaatg cagagtatgc tttaaatgaa
    36661 ataaaagaga tgtttgttag catgtttgag tctatggaca atgagtacat gaaagaaaga
    36721 gcggcagata taaaagatgt tacaaataga atacttagac atatattagg aattaaagtt
    36781 gttgatttat ctgctttaag cgaagaagtt gtattaatag cacatgattt aactccatca
    36841 gacacagcaa ctatgaataa aaaaatggtt ttaggatttt taactgatat aggtggaaga
    36901 acttctcata ctgctatcat gtctagaact ttagaaatag ctgcaatcgt tggattaaat
    36961 gatataactt caaaagttaa ggatggagat tttgtggttt tcaatggaga cacaggtgaa
    37021 gtaatcgtga atcctgatga agagactata aataaatata ctgaattaaa agctaagtat
    37081 gaagatgaga gaaaagcatt acagctatta aaaggaaaac catctgtaac tttagacgga
    37141 aaacatgtgg aattagctgg taacatagga acacctaacg atatagaagg tctaataaag
    37201 aatgatgctg aaggtgttgg tctttataga acagaatttt tatacatgga tagagattct
    37261 ttcccaacag aagaaataca atatgaagca tataaagctg tattagaagg aatggatgga
    37321 aagcctatag ttataagaac attggatata ggtggagata aagaattaag ttatttaagt
    37381 atggaacctg aaatgaatcc attcttaggt tacagagcaa taagactttg cctagataga
    37441 aaagatatat ttaagactca attgagagct ttatatagag ctagtgttca tggaagatta
    37501 agaatcatgt tcccaatgat ttcatcttta gaagagttgt tacaagctaa agaagttgta
    37561 aaagaagttt tagcagaact tgattctgaa ggtgtggctt atgctaaaga tgtagaaatt
    37621 ggtatgatga tagaagttcc atctgctgct gtgatatctg atgtattggc taaacacgta
    37681 gatttcttct ctataggaac taatgattta attcaataca cttgtgcagt tgatagaatg
    37741 aatcaaaaga taagctatct ttacaatcaa tttaatccag ctgttttaag acttataaag
    37801 actgttatag acaatgcaca taaagaaggc aaatgggcag gtatgtgtgg agaatctgct
    37861 ggagaccaaa aaatgatacc aatactttta ggtatgggat tagacgagtt ctctatgtct
    37921 ccaatatcaa tacttcctgc tagaaagtta ataacttcag ttaaagagtc agatatgaaa
    37981 aaattagctg atgatgtact taatatgggt actgctgaag aaataaaaag ctatatagaa
    38041 aagactttta atatataatt aatgttatat agttactaaa attcattttt ctaaataaca
    38101 aaattatatt ttacgaatta aaaaggagat gtttcaaaat aaaaatttga agcatctctt
    38161 ttttataaaa gattactaag aattacttaa tctttgtaat agtcattttg tgaaaaagca
    38221 aaactgcatt gtggctatag tatatatgga tgttattatc aataaaagta ctattaaaat
    38281 gaagattcat tctcaaatga tatcaaaagt agttgtgatg gagtaagata atattttgtg
    38341 atttaatagt aaaaattaaa aaaatatggt attgaaaaat aattaaaagt atttaataat
    38401 agaattaggg aagaataagt ttataagtaa aaataattga ttactagtta ataaaataaa
    38461 tgtgatatcc aaataaatcc taaatctaat ttgagtttta atatagatag tctaaagttt
    38521 gattattaaa gatttaattg taagttgtta cagttgatga tattgattag agattaaagt
    38581 ttagagtaga aagttacctt aaatttaaaa atgcaagata acccaatcta aaaattataa
    38641 tcactcaata ggtttaagga tttatttgtt tattataaat aggagggtgt ctcaaaatga
    38701 actttttagt ttatgaggca ctctctttta tatagaatta aatatatttt attatttcaa
    38761 caatgaaaaa gaagcttatc tctattttga gacagcctct ttgtatacta ttattaattt
    38821 aatcaataac ataatttaaa actatattat tagttaagat ttcctgcttt attagtaaat
    38881 aattctttaa tagcattgtt tctggaaact aaatcgttat cagagttgtt tgtttttttc
    38941 ataatcactg aataacgttt tttatttata aaaaatatta aaatcttatc atcatcaaaa
    39001 ttgtattctt tatatctgtc aatagactca taacctagat ttagaatgtt tttgtctttt
    39061 atactatcta catctaaaat atatgatggg tcagccttta gtaatatatt aattaaacat
    39121 ttttcttcac cagcacagaa taactccatc ttacttgata tagatttaga ttgctctgaa
    39181 gttatttttg caggaataag gttgtcattg tcatctctta gaagataacc atgtgtgtct
    39241 tgttgatata ctaaattaac ctttttctta ggaacactaa tcattttatc taaatgtaca
    39301 taatgatgat tttcaacaaa accttcattt aatatttcaa caaagttatt aattttacct
    39361 aggcaaaaag attctataga ttctttacag aatttatttg taaatggtat tatgtttacg
    39421 ttttcctcgt ctgtattcca tgctatagca taatccaacg aatatacttc ttcctctata
    39481 tctgcaaaat tatattgtac tatgtttcct ttcaaaatta ctcgacctcc atcttataat
    39541 atatttaata tactttataa aacttatat
//
LOCUS       DAEHWM010000030        38567 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.031, whole genome shotgun sequence.
ACCESSION   DAEHWM010000030 DAEHWM010000000
VERSION     DAEHWM010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 38567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 38567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..38567
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.031"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(204..2591)
                     /gene="cadA"
                     /locus_tag="KNP36_001609"
     CDS             complement(204..2591)
                     /gene="cadA"
                     /locus_tag="KNP36_001609"
                     /EC_number="7.2.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase"
                     /protein_id="HBF0873487.1"
                     /translation="MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFIN
                     KKLTVNIKESFNEDTTIEKIIDIIDSTEPGLDIQISSKENAASKTSIKKELILGGLNC
                     AHCAEEINNKVSKLKEVESSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLD
                     IQVGSTDKVKGRTTEKSGAVNDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVF
                     IVAYVIVGGDVLLRAIRNISKGRVFDENFLMALATVGALAIGELSEAVGVMLFYKVGE
                     YLQGVAVGKSRKSITSLMQIRPDYANLKVNSEVKVVSPEEVNVGDIIVVKPGEKVPLD
                     GVVVDGVSMLDTSALTGESVLREVEKGDEILSGVINKNALLSIEVTKSFGESTVSKIL
                     DLVENSSIKKSKTENFISKFSRYYTPIVVIAALLIAFVPPLVISGEVFSDWLYRGLIF
                     LVVSCPCALVLSIPLSFFSGIGFASKNGILIKGSNYLEALRSVDTVVFDKTGTLTKGV
                     FNVTKLNPEGISEEELLEYAAIAEVNSNHPIAKSILSYYNKKIDLDTIDSYEEIAAYG
                     IRVKHNGNFILAGNEKLMKKENISYSSAKEVGTVVYIAVDKAYRGYIVISDEVKEDSK
                     NAIRSLKEIGVKEVVMLTGDNEKVAKNIAQELELDTVYSNLLPNEKVDRLEDLYEGRT
                     EKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMTDEPSKISKAIEIA
                     NKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADVGVALIAVVNAMRAMR"
     gene            complement(2614..2979)
                     /locus_tag="KNP36_001610"
     CDS             complement(2614..2979)
                     /locus_tag="KNP36_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0873488.1"
                     /translation="MREEINDCNCNIVHEEIVTEAKSTMPDEEMLYDLAELFKVFGDT
                     TRVKILYALFANEMCVCDIASLLNMTHSAISHQLRVLKQARLVKFRREGKTVYYSLDD
                     SHISQIFDCGLNHIRETYK"
     gene            3178..4026
                     /locus_tag="KNP36_001611"
     CDS             3178..4026
                     /locus_tag="KNP36_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873489.1"
                     /translation="MSNKKKKDLDTSYMPYLDPANYADYITNEEIPQDELRNDPQISN
                     GYTKIPNNQNINNLYPNNVNHYPKSSNSPNNLPNTNNTSGNMNYNTSATNNMPNNMNN
                     NTGMPNNMSNNMNSNMGMPNNMPNNMNSNMGMPNNMPNNMNSNMGIPNNVPNNMNSNM
                     GMPNNMSNNMNSNMGMPNNMSGNMNNNMYGNTGMPNNMNSNMGYNMNNTMGIPNFSCN
                     QNMPPNVLMMIPGVICHNTMQGMPVVMPSTMPPNIYPTPYGSSNMSIQGIPQATNIEE
                     FDEEEM"
     gene            complement(4463..5551)
                     /locus_tag="KNP36_001612"
     CDS             complement(4463..5551)
                     /locus_tag="KNP36_001612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873490.1"
                     /translation="MNFNFAKATNSRLMGSLGLIINWIDDENNHFCQYFLLDAEGLGL
                     ADYVSLNNPTQEEAYMEEERLMGGFGSDRVELTKDESLFLVSYFGNKNLYYDKLLPGD
                     KCEYIDIIKNYKTDLTIEKLYNKICKRVDEEVEFINYMTMRFIAWDRESLKYFSGSDE
                     IANMHITNINGTLLKNVVSDKGQGRYISEALYEDNDGYYICKIAFCISKCYETGFRIN
                     SLLVTDKEPMYDFEVFDEISKSEFVSVYSVNSPEEFAGVFYRENPFLLKSNMNEGIFF
                     TRFNFNNDHVKENVYIINNDMKAIYYLMGNKFFIGTYNENDCNYINEISQSNYSDYIK
                     FEEKFFFEQNALYDFAESGSLDFDDFLE"
     gene            5676..6404
                     /locus_tag="KNP36_001613"
     CDS             5676..6404
                     /locus_tag="KNP36_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family hydrolase"
                     /protein_id="HBF0873491.1"
                     /translation="MKNIAAFFDIDGTLYRDSLMVEHFKKLIKYDIIDQKNWYKHARD
                     TFMDWDKRQGNYDDYLLEICDLYVDSLKGLDKTCINFTSDQVIKLKADRVYKYTRSRI
                     EWHLNQGHIVIFISGSPGFLVEKMAKKYNVTDFLGSDYVFENNIFTGTVIPMWDSISK
                     NNAINDFVVKYDLDLSNSYAYGDTNGDINMLKRVGNPIAINPTKELLSQISLDEEISK
                     NVEIIVERKDIIYSLSTDVNIVDI"
     gene            complement(6608..7099)
                     /locus_tag="KNP36_001614"
     CDS             complement(6608..7099)
                     /locus_tag="KNP36_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873492.1"
                     /translation="MSIKVAYGGVLLALNVILLTLTNIIPVNTLFIMGLASLLVSIVI
                     MEWGFKSGIAFYIGSIVLGFIVMASKSQWIVYSLTFGIYGIVKYLIEKDRSIYIEYFM
                     KLVFANIMILILYFLLRTIVYIPINIFIIGSFEIAFIVYDYVYSSFIGYYNNRLRKML
                     FKK"
     gene            complement(7110..7553)
                     /locus_tag="KNP36_001615"
     CDS             complement(7110..7553)
                     /locus_tag="KNP36_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873493.1"
                     /translation="MYSNTYNNENFMRARAFIENSEFKKAYDFLKTLTDKCAEWYYLT
                     GFSAMNIGYYEEGEDFLKRAKFMEPENSEYSDALRSYTQYRNDYSNRADNYNRRRRND
                     LDGCCCCCCDDCCCCLGDDCCENCAKLWCLDSCCECFGGDLITCC"
     gene            complement(7543..8382)
                     /locus_tag="KNP36_001616"
     CDS             complement(7543..8382)
                     /locus_tag="KNP36_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873494.1"
                     /translation="MFGYVKINKMDLTFREYDYYKAYYCGLCKYLKRNHGEISRFSLN
                     YDITFLIVLLTAVYNPESISTEEVCIVNPFKKKKVITNDITEYAASMNILLTYYKLED
                     NLMDDKRIKDKLAYYIYKNKLKLAYEKYPEKAEYIKQQLNELNKLEKDKNINIDEVSS
                     IFGNIMGEVFVYKKDENERNLRMIGFNIGKYIYLLDAYEDLDEDFKKGRYNPFIEYID
                     KNDELKEKVKKIIVTSLGFLARGIDNLNLNKNVGIIENIIYSGVYLRYINILESRGGK
                     NVQ"
     gene            complement(8601..9986)
                     /locus_tag="KNP36_001617"
     CDS             complement(8601..9986)
                     /locus_tag="KNP36_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0873495.1"
                     /translation="MENLNKKFLMEYIDEIQGELRDISDKIWKNPELQYKEYYASNLQ
                     KEYLKKYGFSIDELEGMDTAFAASYGEGRPVIAVLGEYDALDSLSQKVSTIKEPIVDG
                     GAGHGCGHNLLGTGSIGAVIAVKELIKLKKLKGTIKYYGCPAEEDLSGKVLMIKKGFF
                     DGIDCAFSWHPFDINTPIRIPTLANYSVKFRYNGISAHAAQAPYNGRSALDAVELMNI
                     GCNYLREHIFDNCRVHYVTTNGGKMPNIVPDFAEVWYYIRGVKMEHVRDVFGRIVDIA
                     KGAALMTGTIMEYDIISGVYDYIPNTILTDILSQNMKLVGVQNYNEDDYYFADKLAET
                     VSIDKRSSVSSVLSGNKDITKMNLHDEVTDDTFTHNNCISLSLDIGDVSYIIPTAQCS
                     CSVWPIGISAHTWQSCASAGSDMGFKAMLLASKSISCSINDVMLDELVINKAKKELKD
                     TVGSFKYIPII"
     gene            complement(10159..10902)
                     /locus_tag="KNP36_001618"
     CDS             complement(10159..10902)
                     /locus_tag="KNP36_001618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytoplasmic protein"
                     /protein_id="HBF0873496.1"
                     /translation="MKKVLIVGESWVKNITHIKGFDTFVTTHYEEAVKWLKEAIESGG
                     YETVHMPAHVAADSFPYKLEELNEYDCIILSDIGSNTFLLSNSTFIDCNSNPDRLELI
                     KEYVNNGGALIMVGGYMSFTGIDAKARFGETAIKDVLPITMIDKDDRVEKPAGIIPEV
                     IDSKHPVLKGIPTEWPKFLGYNKTVARDNCPVLATIGGDPFVAVGEFGKGKSAIFSSD
                     CAPHWGPKEFTDWKYYNKLWVNMLDWLTC"
     gene            complement(10922..12184)
                     /locus_tag="KNP36_001619"
     CDS             complement(10922..12184)
                     /locus_tag="KNP36_001619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0873497.1"
                     /translation="MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGFEKEGQ
                     EYIEKLANYIGFSVDRQEMSEELIKKAKNIYKEGNLGHNYQDRYNLICKYSDDLPGKT
                     IVFNGHVDTMPPGDISKWKYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSG
                     LNVPGNVKIMSVVDEEGGGNGTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVE
                     VKGVSLHCGSKWEGVNAIEKAMLLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGT
                     AGSTVPDKCVFNLCVHFLPNIMSYEQVVNDVTNVIMTRANGDLWLKDNKPNINIYQSG
                     LGFEMDKDSDFVVNAHKILEETLGKKLEIKGSTAGNDARLMKNLAEIPTLILGPGSIE
                     QCHSIDEYVEIKEYLDSILMYASLILNL"
     gene            complement(12368..13366)
                     /locus_tag="KNP36_001620"
     CDS             complement(12368..13366)
                     /locus_tag="KNP36_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose ABC transporter permease"
                     /protein_id="HBF0873498.1"
                     /translation="MSSITKHKEEKSSPLLTKLTSVFRDQGSAAVGLVIIFIIMSVAS
                     SNFLTLDNLINVGRQISINAILAVGMTFVIITGGIDLSVGAVIALVGTFWATTVVNYN
                     APIWVGMILALAIGTILGVIKGAIISTQKLPPFIVTLAMLTIISGASFVFTGGRPISV
                     NTDAFKMLGRGYIGPIPIPVIIMIIVVIAGHFLLKRTNFGRHVHAVGGNEEAARLCGV
                     KVNKVIVKVYALAGLLTALAGIILSSRLASGSPTVGDGAELDAIAAVVLGGTNMMGGS
                     GSIVGTCIGVGIIGILGNGLNLLSVSSYNQMIIKGLVMLFAIWINNIKLKKSAKSK"
     gene            complement(13350..14861)
                     /locus_tag="KNP36_001621"
     CDS             complement(13350..14861)
                     /locus_tag="KNP36_001621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="HBF0873499.1"
                     /translation="MSNIILKLSNIAKEFPGVRALDNVNFELFHGEVHALLGENGAGK
                     STMIKILTGAHSKTSGKFIFEGKEIENISPDISKKIGINAIYQELTVFDELTVAQNIF
                     MGKEINGKVLTNDKKMNEEAKKIFDNMGIDINPNSLVKELSIAQKQMVEIARVLSSET
                     KVLIMDEPTSSISKKETEILFRLINDLKESGVSIIYISHRMEELFEICDRITIMRDGK
                     TISTLNTKDVSSEEELVNLMIDRKLDQFFPKRKVEIKEEIMRVENLTKNNVFNDISFN
                     IRKGEILGIGGLVGSKRSEIVEAIFGLRTYDSGKIYLNNEEVKFKTPSDAIENGLGLI
                     TEDRKGTGLFLQMSVKENTTMAGLKKISKFKSIIDRKKEKEILEKYIEALKIKTPHMN
                     QVIQSLSGGNQQKAIIARWLLLQPDILIMDEPTRGIDVNAKAEIYNLMGDLVESGVSI
                     IMISSEIPELISMSDRIMVMREGHISGFLEGEEMVENNVLKLAFGGKINEFNN"
     gene            complement(14915..15877)
                     /locus_tag="KNP36_001622"
     CDS             complement(14915..15877)
                     /locus_tag="KNP36_001622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HBF0873500.1"
                     /translation="MRVRKILSLGIAGILAIGMLTGCSMEGPSKSDNKGGSDKKDLTI
                     GVSTITLQHQFFIDIDEGIKEKAKELGVKVIVNDPDQDVAKQTSAIEDFIQQNVDGMI
                     VLGTDNSAIVPAVEGAFEKMPVVTVDAVLNTENITSYVGTVSYDAGKKLGEYTKKYID
                     EKLGGKSEIAIVTDLKSQIQMQRIDGFKDALKGSANVKILNSQPGYDREESLNTVENL
                     IQSNPDVDIIYATAENSVLGAKAALESAKNKDVKIVGFDLTEEASSGITDGTILAMIQ
                     QQPKEMGRLAVEAVVKAIKGEKVEKNIPVPALLYDKENIKDFKN"
     gene            complement(15925..16815)
                     /gene="rbsK"
                     /locus_tag="KNP36_001623"
     CDS             complement(15925..16815)
                     /gene="rbsK"
                     /locus_tag="KNP36_001623"
                     /EC_number="2.7.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribokinase"
                     /protein_id="HBF0873501.1"
                     /translation="MGNIVVIGSVNMDMVCSVDKRPEKGETVLGNSFFTSPGGKGANQ
                     AISASKLGANVKMISCIGEDGLGEELIRNFRTNKVDYSLVSRNNHKSSGVAVITLCEN
                     DNSIVVVPGTNELVDIELIKKNEEEIKNADIVLLQLEIPLKTINYVVNFCFENRIRVL
                     LNPAPAVKLNEDIIEKVTYLTPNEHEYKIVFDTNEGIEEVLKKYPNKLVITEGKNGAR
                     FYDGEEIKHVSCISVDVQDTTGAGDTFNGALAVAITEGKNLYTAVEYAVVVSGLSVTK
                     LGAQSGMPYKEDVEKYLNNK"
     gene            complement(16857..17870)
                     /locus_tag="KNP36_001624"
     CDS             complement(16857..17870)
                     /locus_tag="KNP36_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBF0873502.1"
                     /translation="MSITIKEIGELAGVSKTTVSKVINNKDENISQATREKILKIMKE
                     KNYVPNKLAQSLVTKKTNTIGLLIPDIRNPFFTDVSRGVEDKANEEGYNIILCNTDED
                     AKKEYEGIRTLSERMIDGIIFAASSNTNWKEANYKDIKIPTVLIDKKISMNKETLKGI
                     VKINNFEGAYIATKHLLDIGNKKIIYLSGPLQNEIAVDRLEGYKKALIECNLSYNPAY
                     VFEGKYKIEWGQEFIKNLEKIDFDAIFCANDLIAIGVIRGLKERGLSIPNDISVVGFD
                     DIQTSSLISPSLTTVKQPSYDIGYKASEILINCLRGDKKESFDELIFKPELVIRDSTK
                     ESE"
     gene            complement(18099..19076)
                     /gene="bioB"
                     /locus_tag="KNP36_001625"
     CDS             complement(18099..19076)
                     /gene="bioB"
                     /locus_tag="KNP36_001625"
                     /EC_number="2.8.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin synthase BioB"
                     /protein_id="HBF0873503.1"
                     /translation="MEKYIIKLKNKVLREKEISYEEALNLISLDTNNKNDFDILLKSA
                     NEIREYFMGRKADLCTIMNAKSGKCSEDCKFCAQSSHYKTGVEEYSLLDYNEILNRAK
                     EMESKGVHRFSLVTSGKGMSGKEFNNILNIYEGLRENTNLKLCASLGIIDYEQAKMLK
                     SAGVTTYHHNVETCRDNFHNICTTHTYKDRIKTIKDAKKAGLDVCVGGIIGMNESEEQ
                     RLKMAFEIRELNVKSFPINILNPIKNTPMENYDVLEPMEILKTTAVFRFIIPNVYIRY
                     AGGRLSLKGYDKVGFNGGVNSAIVGDYLTTVGSGIENDKKMIIEQGFEL"
     gene            complement(19282..19545)
                     /locus_tag="KNP36_001626"
     CDS             complement(19282..19545)
                     /locus_tag="KNP36_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873504.1"
                     /translation="MKIYYEKENSKKANVNNIPSVFAFNFLRNFLTSKEYEETRKEYF
                     INNLTKSQVNQAMKDLKWLFREYEGLEVITMESLDGVKTRIVL"
     gene            complement(19615..20688)
                     /locus_tag="KNP36_001627"
     CDS             complement(19615..20688)
                     /locus_tag="KNP36_001627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF362 domain-containing protein"
                     /protein_id="HBF0873505.1"
                     /translation="MEKSKVYFCDLYSNSQNKNVPNNVRRLFDEAGFKDLIEKNDQVA
                     IKLHFGEKGNTTYMSPVAVRQVVDKVKDCEGKPFLTDTNTLYTGSRTNSVDHLTTAIE
                     NGFAYAVVNAPVIIADGLYSRNYENVKIDKKHFESVKIGGEIYNSSAMIVMSHFKGHE
                     AAGFGGALKNLAMGCASAAGKQMQHSDVTPVVKEKKCVGCGKCVNSCPTKAISIVDKK
                     AVIDSDVCYGCGECPTVCPTRAVTIQWESDSDVFVEKMAEYAYGAVSNKKDKVGYITF
                     VMNVTPLCDCVPWSGRPIAHDIGILASTDPVAIEQACYDLICKEMGHDVFKHEHPHVN
                     GTRIIDYACEMGMGSKEYELIKL"
     gene            complement(20936..21694)
                     /locus_tag="KNP36_001628"
     CDS             complement(20936..21694)
                     /locus_tag="KNP36_001628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873506.1"
                     /translation="MREYIAFTKKEFKENLRNYKLFSLIILFLIFGISSPISAKFMPD
                     LIAHFAPTLKVTAAPTALDSWTQFFSNISGLGMSLTLIIFCNILSNEYSKGTLVIMLT
                     KGLSRSSIVLSKFSVTVIIMTIGFWLSFLFAYGYTIYFWPTANLNHIIFSAFNLWLIG
                     IMYISVLILGCVLFRPAFASVLLVLVATLLLSLISIPKQIAPYTPNFLMSKNIDLISG
                     KVAMPEFIIPIIITVLISVVCLLAAVILFNKKPV"
     gene            complement(21691..22608)
                     /locus_tag="KNP36_001629"
     CDS             complement(21691..22608)
                     /locus_tag="KNP36_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873507.1"
                     /translation="MNIVSINGLSKGFGNRKIIDNLNFTVPEGSVFGFVGKNGAGKTT
                     TMKMVLGLLKPDSGTIDVCGEKVTYGKTSSNRHVGYLPDVPEFYNYMRPLEYLSLCGE
                     ITGLSKKEIQIRSEELLSLVGLGNEKRRIGGFSRGMKQRLGIAQALLSRPKLLICDEP
                     TSALDPVGRKEILDIMLKIKDSTTVIFSTHILSDVERICDHVAILNKGSIALSGTLSE
                     IKSMHGKDRLLLEFASNDEIQKFKSSDGIKSLLKDSEETNMEIVLHGKDIKAIQKTVI
                     STLAEMNLCPVKMELIELSLENLFLEVVK"
     gene            complement(22608..22808)
                     /locus_tag="KNP36_001630"
     CDS             complement(22608..22808)
                     /locus_tag="KNP36_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLDc_N domain-containing protein"
                     /protein_id="HBF0873508.1"
                     /translation="MENLMEYLPLLVPVIILDLILIITALVHVLRHPNYKIGNKAIWI
                     IVVLFISLIGPILYFTIGRGEE"
     gene            complement(22813..23907)
                     /locus_tag="KNP36_001631"
     CDS             complement(22813..23907)
                     /locus_tag="KNP36_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873509.1"
                     /translation="MNELNIAKTLILKRKEKGITQDELANYIGVSKASVSKWETGQSY
                     PDITFLPQLATYFNITVDELICYEPQMMKEDINKLYNKLCKDFTVKPFDEVMDEIREI
                     IKKYYSCFPLIFRMGLLIVNHYDIVDEKKRELLISEALEIFIRIQETCNDIDICRQAK
                     SMEATCYILLNQPIQVIDLLQNSNFPMINESILLAQGQMMNGQMDEARETFQLGAYQN
                     LISLVQNLVGILQNADKLQMKEIERRILAISDIFELDTLSPAIMLSSYLTQAQINLIH
                     GDNEGAIKSLRKYVDLATRDIYPIIIHGDDFFNKLDRWISEIGTGITRDDTIVKAGIV
                     AAIKNNPMFSVLSENKEYKFLIEKLSLLEE"
     gene            complement(24417..24557)
                     /locus_tag="KNP36_001632"
     CDS             complement(24417..24557)
                     /locus_tag="KNP36_001632"
                     /inference="COORDINATES: protein motif:HMM:NF021468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2185 domain-containing protein"
                     /protein_id="HBF0873510.1"
                     /translation="MNGEGCILSNKITKECYKVGYMIREKSIDTYPDSGWGFMTWDEN
                     GE"
     gene            complement(24867..26174)
                     /locus_tag="KNP36_001633"
     CDS             complement(24867..26174)
                     /locus_tag="KNP36_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0873511.1"
                     /translation="MDISRSVDNSLNRTIEFLKELIKIDSQQGEPISQCPFGIGPKKS
                     LDKTLDYCASLGFSVKNIDNYIGYAEIGEGEELIGIPMHLDIVPPGEGWSVDPFSGAV
                     IDNIIYGRGVIDNKGAVSMLIHVLKNIEDMYPTINKRIRLIFGTNEETGMKCIKYYLD
                     KGEEIPSMGFTPDAMYPVVNGEKGRVHIRIEKEIKIDKSKPYIIVRGGTKENVVPSHC
                     TAKIINGIISELTTKGVAVHASNPEKGENAISKMVIKIVEDNMDFQHREDIELVSKYL
                     CSDYYGDALGINQYDEVFKNTTLNLGILKVNEEKIVCELDIRYGKNIVLNNIIDRFKK
                     VFCNGWKIEVIAHKDLHYVDESNLVLKKLLEAYEEVTDENGYTIAMGGGTYASWFKDM
                     VAFGPKFLAYKTGGHGVDERVPINHIRKNMEIYTLALIKLLEL"
     gene            complement(26239..26718)
                     /locus_tag="KNP36_001634"
     CDS             complement(26239..26718)
                     /locus_tag="KNP36_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-2-amino-thiazoline-4-carboxylic acid
                     hydrolase"
                     /protein_id="HBF0873512.1"
                     /translation="MSEKMYTEKEYLEGIRGATGERAVWFYLLMKEAEKLGANPDDIC
                     KEAIYGFGKMRGQKYNVADTPGKMAEMLYNSKGQKVFEMELVENTDENGVLKFHHCPL
                     DAAWKEYGLTKEERKEICRLACYGDYGRVDCAQGVKLDFAQKCAHDDEVCELVFTKK"
     gene            complement(26765..27628)
                     /locus_tag="KNP36_001635"
     CDS             complement(26765..27628)
                     /locus_tag="KNP36_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBF0873513.1"
                     /translation="MQEIKNKEVKNGQGPTEVNKTRVLTKKDVTKTYLRWWWTAELSN
                     SFERMQALAVCASFTPALEKLYKRKEDLVDALKRHLQFFNTQAIWGGLIHGTVLAMEE
                     EKATEGKIPGEVISGVKNGLMGPLAGIGDTLDFGTFQTIFLALGASFGAEGSVIGAFF
                     PIMFSILLFCEGYYLFHLGYSLGRDSIKKILSGGIVNKIIDGASILGMFMMGALSATT
                     VKLSTPLSFDIGGKAIVVQDTLNMIAPGLLPLGVVFFVYWGMKYKKWTITKLLVILVV
                     LALVGSFIGIF"
     gene            complement(27628..28383)
                     /locus_tag="KNP36_001636"
     CDS             complement(27628..28383)
                     /locus_tag="KNP36_001636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0873514.1"
                     /translation="MESVLMLAIVTGLWYWFAAGLAGYTLFSTLKSPLFIGFSLGLLW
                     GDVTTGMIVGASIEMVYLGMVAAGGNIPSDKCLAALIAIPVALQTGVNAEVAVSIAVP
                     LGVIGVLVNNLRRTGNAVLVHKADKYAEEGNTKGIWRCATLYSLIFGFVLRFPIVFVC
                     NFFGADLVQSLLDVIPQWLMNGLTVMGGILPALGFATTIFTIGKNKFLPMFIIGFFMV
                     QYFEISITAAAIFGVCIALLITFMKEDKRVGEV"
     gene            complement(28410..28898)
                     /locus_tag="KNP36_001637"
     CDS             complement(28410..28898)
                     /locus_tag="KNP36_001637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0873515.1"
                     /translation="MAKITLVRVDHRLIHGQVITKWVKIAQAQKIIIVDDFLGQDEFM
                     ADIYKMAAPSGVEVVILTAEDAGQAFQNNTLGDKNIFILFKNVDMANKAYKAGLKYEK
                     IQLGGIPNEAGKKMVFTAVSLGNEDVEQLNELNENGVEIVLQVIPEESSMTYENALKK
                     FK"
     gene            complement(28916..29317)
                     /locus_tag="KNP36_001638"
     CDS             complement(28916..29317)
                     /locus_tag="KNP36_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIC"
                     /protein_id="HBF0873516.1"
                     /translation="MNKYKVIILCHGTWGKVLVEETNKNFGLSNQYEVLSLSSEKDVS
                     VFMKEVEEVVDKEDVKIIISDLYGGSTSSVAIAVAIRRGIDAINGLSLQTILIVDEEL
                     SKEDKLHTLPERIVKKNNNLCVDLIKEFKKI"
     gene            complement(29320..29817)
                     /locus_tag="KNP36_001639"
     CDS             complement(29320..29817)
                     /locus_tag="KNP36_001639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0873517.1"
                     /translation="MSLVKYCRCDDRLIHGQVIYKWVKHLGVKKIVVVDDETTNDVIA
                     KGLIKMAAPKNIDLSILTVSESRRYFYNNQADDNVFVLIKNLDTANRMIEEGINIKKL
                     IVGRIPTGIGKKKISQNVYINKKEFLLIDEFIKKNINVSIQMVPDEEEVELNQNINRY
                     KGEFI"
     gene            complement(29841..30245)
                     /locus_tag="KNP36_001640"
     CDS             complement(29841..30245)
                     /locus_tag="KNP36_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0873518.1"
                     /translation="MIGIIVMTHGSFSEEIIKSCELIAGPAERTAAIKLNRNDNIEDL
                     NKNFVEKLNELDEGDGVLVLADLLGGSPSNVASLNLKKGGKFHALTGVNLPMLLEALI
                     NREGKSLEELAEACIEAGQTGINNINKVLSSM"
     gene            complement(30475..33042)
                     /locus_tag="KNP36_001641"
     CDS             complement(30475..33042)
                     /locus_tag="KNP36_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0873519.1"
                     /translation="MTQKKLSRKEKVLICLKRLTEEHLNFNNGIRFGFDAEYIATEVG
                     INRSNASKELNQLIKESIIIKIKGKPVQYLYKESIESILGKKLNKGIFDNINSINEYS
                     ENDSIKDEYILESIKKENNIFNLVGCDGSLRSQIEQAKAAVIYPPKGLSTLIIGPTGV
                     GKSIFAEYMYKYSLTIKEDSDNAPFIIFNCADYSDNQQLLLAQLFGYVKGAFTGADKD
                     KYGIVHEANNGVLFLDEVHRLSAEGQEMLFLLMDKGIYRRLGEANKVHECRVMIIAAT
                     TEDPETAMLETFLRRIPVTIKIPSLEERGFQERMKLICYFFKEESVRIGVKLKVSKEV
                     IKAFILYKCKGNIGQLKSDIQLICARAFLDYMTYKRECVYVRLSLLPNNIRESLYGNN
                     RKEEFVQNFSFIGKDDIIFLPEEKDFESENLLIENKKYDLDFYGMIKETWNKLQQEGI
                     KESQIRSVIDGDIQKYSYNLMNTFIYNSSNQTAYNNIVNDSIATTVKYILQKHDKWSK
                     REGLDKLIKAIALHIQNLIERIKIGNIVKHPNKDEIMKERAYEYNIAKEILSNMSLMY
                     GVEFPEDEAIFLATFLYLSYVGLNEESIAILVIMHGESTASSMVNVANTLLDCNHAVA
                     INMGLEDRVQDILVQAVEIANKIDKGKGILILTDMGSILTFAKVIRDATGKEVKAIDM
                     VSTPIVIEATRKALTPEMTLEKLYFNIIESIKKHYGDMEVTYAEKDNGGRYFDRLLID
                     NISKTLTFLNGEKAYFILKEVINRISEHYSLVIQDELLVKFIFHCSCMIERVIIKESL
                     VYKSYEERISRNKELYLVIKESFKLVEETFDIIISDMEYANILDIFESQYDTDKFKS"
     gene            33208..33951
                     /locus_tag="KNP36_001642"
     CDS             33208..33951
                     /locus_tag="KNP36_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase"
                     /protein_id="HBF0873520.1"
                     /translation="MNFLSDLHTHSIVSGHGYSTLLENINYCKENGIKILGTSEHGPK
                     MPGSPHRWYFHNIQNIPRIINNIIILRGCEANILDIKGNIDLEPFVIPRLDYLILSFH
                     EAVFSPNTLENNTKALINAINKHDNIEILGHLGNPNYPIDYELIIKLAIEKNILIEIN
                     NCSIKGVSRNGSSDNCKYIATLCKKYGAKIILTSDAHICFDIGNYEYSENILKEINFP
                     DELIMNYPKKLINHFHQKGKLLDVDYTNI"
     gene            complement(34263..34469)
                     /locus_tag="KNP36_001643"
     CDS             complement(34263..34469)
                     /locus_tag="KNP36_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873521.1"
                     /translation="MSKYSSLWEYVKKNNSQSFKLTFEEIKDIAGIEIDHSFLKYKKE
                     LNEYGYQVGKISLKEKTVIFDKIG"
     gene            complement(34872..35267)
                     /locus_tag="KNP36_001644"
     CDS             complement(34872..35267)
                     /locus_tag="KNP36_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBF0873522.1"
                     /translation="MKALEFLNKAGVYYLATVDENNQAHVRPLGFVMEYNGKLTFCTS
                     NQKDMFKQLIFNPKVELCCIDQNLNTLRILGEAVFVTSKETQAKALEIMPSLGQMYSV
                     GDGKFEIFSIDKAKVSCCSMSGKKIDVEL"
     gene            35408..35800
                     /locus_tag="KNP36_001645"
     CDS             35408..35800
                     /locus_tag="KNP36_001645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873523.1"
                     /translation="MSINTEKNITKNVEELTCPIRYALDIVGGKWKLPIICMLAVENP
                     IRYSSIKRKLDGITNTMLAQSLKDLESTGIVHRKQYNEIPPKVEYTLTSKGKSIVPIL
                     QQFANWGATNMQEKNTCGLSCKECRKIK"
     gene            complement(35900..36316)
                     /locus_tag="KNP36_001646"
     CDS             complement(35900..36316)
                     /locus_tag="KNP36_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBF0873524.1"
                     /translation="MNWQDAFFQDTKPTFEQINEFINNPLWDKLNKTLVSTYNVEPKL
                     EYSKCSMQRGWNVKYKKRGKSLCTLYPQEGYFKALVIVSESNRVEVDLFINTCCDYIK
                     KIYNEVNFFNGSKWLMIQVDSLLVLNDMLELIKFRA"
     gene            complement(36331..37242)
                     /locus_tag="KNP36_001647"
     CDS             complement(36331..37242)
                     /locus_tag="KNP36_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0873525.1"
                     /translation="MHAWESIQITLDLIEANLSEEISINELANKANLSPFYYQRLFKR
                     LVNKTVMEYIKLRRLARASEYLAEHKNRILDVALNFGFASHETFTRSFKKAYGLTPEK
                     YRANPVKLNHFIKPELILNYAMVDEGVPLIADDIVIEVNRKTLSNPRTFVGIEIEVPI
                     CQLVGGETTGIAIVEELWMKLGSQRHNIPNQIPGGNEFAALYMGNAKEGNCMYMAGVE
                     VESGTSVEGYSTFELPAKEYLVCGFEAENFNELVNSAVFKADKFMERWMKKHNLTTTD
                     FAIEMYYPTTPEAAYLEHWIVPVPIEQ"
     gene            complement(37424..38446)
                     /gene="splB"
                     /locus_tag="KNP36_001648"
     CDS             complement(37424..38446)
                     /gene="splB"
                     /locus_tag="KNP36_001648"
                     /EC_number="4.1.99.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore photoproduct lyase"
                     /protein_id="HBF0873526.1"
                     /translation="MFNPKRIIFEKGTLDTDVGKKIYNKFRDNKDVEIINISSNRIKE
                     HIPGENLYEQYRSGKQTMVVGIRKSLKFQTCKPSANYQLPLVSGCMGRCEYCYLNTQL
                     GDKPFIRVFVNVDEILEQTKKYIEDRKPQVTIFEGAATSDPVPVEPYTNSLKKTIEFF
                     GREEKGRFRFVTKYSDVDSLLDAEHNNHTEIRFSINTPRIINEHEHYTASANKRIESA
                     VKLARAGYQIGFIIAPVFLYEGWKEEYKNLIISIKEALPKDFDKKIIFEVISHRYTTK
                     AKNRILEIYPDTLLPMENEDRKFKYGQFGYGKYVYDKEQLDDMKEFFLKEINGVFKNS
                     LIKYII"
BASE COUNT        12525 a         7020 c         3983 g        15039 t
ORIGIN      
        1 tttaaaatta caatataaaa gctctacact aaataaatac attaaataaa cataatggat
       61 aatgaatata aatttatata tgcaaagcgc tccaataaaa aggtaccaat aaagttaaaa
      121 gaaacttatt gatacctttc attattacat acttcaatat ataattataa gttttttaaa
      181 tagtatggat ttacatttat cccttatctc atagctctca tagcatttac tactgctata
      241 agtgccacac ctacatcagc aaatatagct tcccacatag tagctactcc tccagcacct
      301 agtatcataa ctataatttt tactcctaga gcaaatatta tgttttgcca cactatctta
      361 ttagtcttgt ttgctatttc aattgcttta gatatcttgc taggctcatc tgtcataagc
      421 actacatctg cagcttcaat agcagcatct gaacctaagc ctcccatagc tataccaaca
      481 tcagcacgag ctaatactgg agcatcattt attccatcac ctacaaatgc tattttctct
      541 ttttcagttc ttccttcata taaatcttct aatctatcta ccttttcatt aggaagtaaa
      601 tttgagtaaa ctgtatccaa ttctaattct tgagcaatat tttttgctac tttctcatta
      661 tctccagtta acattacaac ttcttttacc cctatttctt ttaagcttct tatggcattt
      721 ttactatctt cttttacttc atcagagata actatataac ctctatatgc tttatcaaca
      781 gcaatataga ctactgtgcc tacttcttta gctgatgaat aagatatatt ttcttttttc
      841 ataagtttct cattacctgc taatataaaa ttgccattat gctttactct aattccataa
      901 gctgctattt cctcataact gtctattgta tctaaatcaa tttttttatt atagtaactt
      961 aatatggact ttgctattgg atgatttgaa tttacctccg caatagctgc atattctaat
     1021 aattcttctt ctgatatacc ttcaggattt aacttagtta cattgaacac acctttagta
     1081 agtgttcctg ttttatcaaa tactactgta tctacacttc ttaaagcttc taaatagtta
     1141 cttcctttaa taaggatacc atttttagat gcaaacccaa ttccactaaa gaaactaagt
     1201 ggtattgata aaactaatgc acaagggcaa gaaacgacta agaatatcaa tcctctatat
     1261 aaccaatcac taaatacctc acctgagatt acaagtggtg gcacaaatgc tattaataaa
     1321 gcagctatta ctactattgg agtatagtat cttgaaaact tagatataaa gttttctgtc
     1381 tttgattttt taatgctcga attttcaaca aggtcaagaa tcttagaaac tgttgattct
     1441 ccaaaactct ttgtaacttc aatactcaat aaagcatttt tatttataac acctgataag
     1501 atttcatctc ctttttcaac ttctctcagc actgactctc ctgtgagtgc agaagtatct
     1561 aacatagaaa ctccatctac tactacacca tctaatggta ctttttcacc aggttttact
     1621 actattatat cacctacatt tacctcttct ggtgacacca ccttaacttc agaattaact
     1681 tttagatttg catagtctgg tcttatttgc ataagtgaag ttatagactt tctggattta
     1741 ccaactgcaa caccttgtaa atactctcct actttataga aaagcataac ccctactgct
     1801 tctgataact cccctattgc taatgctcct actgttgcta gagccatcaa aaagttctca
     1861 tcaaatactc ttccttttga tatatttctt attgctctta aaagcacatc accacctact
     1921 attacatagg caactataaa tactatattg ctaaactgac tttcataacc tgtagctgtt
     1981 tgatatatac caaatatata tacaagtgct ccaattataa gtggaattaa ttctttctta
     2041 tttgtatcat ttacagctcc tgatttttca gtagttctcc cttttacttt gtcagtagac
     2101 cctacttgta tatcaagccc tggctctgtt gaatttatta tttcttttat tttatttata
     2161 acatcatcct cttcaaagtt attacttata tttactgtaa gttttttatt tacaaagttt
     2221 aaattagaag attcaacttc ttttaattta gaaactttgt tattaatctc ttctgcacaa
     2281 tgagcacagt ttaatcctcc taatataagc tcttttttaa ttgatgtttt actagctgca
     2341 ttttctttag aacttatttg tatatcaaga cctggctctg ttgaatctat tatatctatt
     2401 atcttttcta tagtagtatc ctcattaaaa ctttccttta tatttactgt aagtttttta
     2461 tttataaaat ttaaattgga agatttaact tcttgtagtt tagaaacttt attattaatc
     2521 tcctctgcac agtgagcaca atttaatcct cctagtataa attctttttt aattgaatta
     2581 tttgcttcca tatatattca ctcctctcat ttatcattta taagtctctc taatatgatt
     2641 taatccacaa tcaaatatct gacttatatg actatcatct aatgagtaat acactgtttt
     2701 tccttctctt ctaaacttta ctaatctagc ctgctttaat actctaagtt gatgagatat
     2761 tgcagaatga gtcatattta ataaactcgc tatatcacat acacacattt catttgcaaa
     2821 taatgcatat aatatcttta ctctagtagt atccccaaat actttaaata attctgctaa
     2881 atcatataac atttcttcat ctggcatagt tgatttagcc tctgttacta tttcttcatg
     2941 tactatatta caattacaat catttatctc ttctctcatt tttaatcctc cattatttta
     3001 atatatgaat aactgttcat atgttcatta tatgttatca tttctaaatt tgcaacaata
     3061 atttttatta atttaatata aatagaatgc acatattata aactttttta atatatatat
     3121 tattagaata agtttttgta aactttttta tagttttcta ggaggtgcaa gtttaatatg
     3181 agtaacaaga aaaaaaagga tttagatact agttacatgc cttacttaga cccagcgaac
     3241 tatgcagatt atattactaa tgaagaaatt ccccaagatg aattgagaaa tgaccctcaa
     3301 atttctaatg gttatacaaa aatacctaat aaccagaaca taaataacct atatcctaat
     3361 aatgtaaatc attatcctaa aagtagtaat tctccaaaca acttgcctaa cacaaataat
     3421 acatccggaa atatgaatta caatacatct gctacaaata atatgcctaa taacatgaat
     3481 aataatacgg gtatgcctaa taatatgtct aacaatatga atagtaatat gggtatgcct
     3541 aacaatatgc ctaataacat gaatagtaat atgggtatgc ctaacaatat gcctaataat
     3601 atgaatagta acatgggcat tcctaacaat gttcctaata acatgaatag taatatgggt
     3661 atgcctaaca atatgtctaa taatatgaat agtaatatgg gtatgcctaa caatatgtct
     3721 ggcaatatga ataacaatat gtatggtaat acaggtatgc ctaataacat gaacagtaat
     3781 atggggtata atatgaacaa tactatgggt attcctaact tctcatgtaa tcaaaatatg
     3841 cctcctaatg tacttatgat gataccagga gttatatgtc ataatacaat gcaaggtatg
     3901 cctgtagtta tgcctagtac tatgcctcct aatatatatc ctactcctta tggttctagt
     3961 aatatgtcta tacaaggtat accacaggct actaatattg aggaatttga tgaggaagaa
     4021 atgtaatata tattttttta agtaagttgt ataaaacatt aataattgac cataataata
     4081 aatgtattcc tcataatatt cccccaatat tattataggt atagaaagtt gactgaatat
     4141 gcgcttattc ggtcaacaga tattaacata atctaataag ataaacatag aaaaagtcag
     4201 ataaaattta attttatctg actttttcat ttaaaaatgc tctcttgtat tggtgggtca
     4261 gaatagtatg atactcgtat ttgagactaa tattggcaaa caacataaag aaaaatataa
     4321 attttttata ataaactgta taaaatttta ataattgacc acaataataa atgtattcct
     4381 cataatattc ccccaatatt atagaaataa atttaagcga gattaaattc agttaatctc
     4441 gcttaaataa tgtctaaatt tattattcca aaaaatcatc aaaatctaat gaacctgatt
     4501 ctgcaaaatc atataatgca ttttgctcaa agaaaaattt ctcttcaaat ttaatatagt
     4561 cgctataatt agattgactt atttcattga tataattgca atcattttcg ttataagtac
     4621 caataaaaaa cttatttccc attaagtaat atatagcttt catatcatta tttattatat
     4681 atacattttc ttttacatgg tcattattaa aattaaatct agtaaagaat ataccttcat
     4741 tcatattact ttttaacaga aatggatttt ctctataaaa tactcctgca aattcttcag
     4801 gtgaatttac actgtaaaca cttacaaatt cacttttaga aatctcatca aatacctcaa
     4861 aatcatacat aggttcttta tctgtcacta atagagaatt aattctaaaa ccagtttcat
     4921 aacacttact tatgcaaaaa gcaattttac atatataata tccatcatta tcttcatata
     4981 aagcttcact tatatatctg ccttgacctt tatcacttac cacgttttta agtaatgttc
     5041 catttatatt agtaatgtgc atatttgcaa tctcgtcact tccagaaaag tactttaaac
     5101 tttctctatc ccatgctata aatctcatgg tcatatagtt tataaattca acttcctcgt
     5161 caactctttt acatatttta ttgtataatt tttctatagt taaatctgtt ttatagtttt
     5221 ttataatatc aatatactca catttatctc ctggcaatag cttatcataa taaagattct
     5281 tattaccaaa ataagatact aaaaataaag attcatcctt cgttaattca actctatctg
     5341 aaccaaatcc tcccatcaat ctttcttctt ccatataagc ttcttcttgt gttgggttat
     5401 ttaaactcac ataatccgct aatcctaatc cctctgcatc taataaaaaa tattgacaaa
     5461 agtgattgtt ttcatcatct atccaattta ttataagacc taaactgccc ataagtctag
     5521 aatttgtagc ctttgcaaaa ttaaaattca tatagtcaca tcctttaaac tctaaaatac
     5581 ttgtttttta atatataaat tattatacat atattttaac aacttagata caatttataa
     5641 tataatataa ggaaatgatt aattgaggtg gtcttatgaa aaatatagca gctttttttg
     5701 atatagatgg tactctttat agagactctc ttatggttga acattttaaa aaattaatta
     5761 aatacgatat aattgaccaa aaaaattggt ataaacatgc tagagacact tttatggatt
     5821 gggataaaag acaaggtaat tatgatgatt atctattaga aatatgtgac ctttatgttg
     5881 attcactaaa aggattagat aaaacctgta tcaactttac aagtgaccaa gtaattaaat
     5941 taaaagcaga tagagtttat aaatacacac gttcaaggat tgagtggcat ctaaatcaag
     6001 gacacatagt tatatttata tctggtagcc ctggatttct tgttgaaaaa atggccaaaa
     6061 aatataatgt aaccgatttt ttaggaagtg attatgtctt tgaaaacaat atatttacag
     6121 gcacagttat tccaatgtgg gattctataa gtaagaataa tgctataaac gattttgttg
     6181 taaagtatga tttagattta tcaaactcgt atgcctatgg agatactaat ggtgatataa
     6241 atatgctaaa aagagttgga aatccaatag caataaatcc aacaaaggaa cttttatctc
     6301 aaatatcact tgatgaggaa atttctaaaa atgttgagat aatagtagaa agaaaagata
     6361 ttatttattc tctatctaca gatgtaaata tagtggatat ttaatttata ctatctattt
     6421 taaaaactta tattatatct aatatttata tctaacatat aaaagctttg actaaaaatc
     6481 aaagctttta tatgttgcac taagagaata tattaaattt agctttatgc tttaatgtat
     6541 attcatatat atcatttaca cttatctaaa ctacaatttc attaaaatta aatataaaaa
     6601 tcaactatta ttttttaaat agcatctttc ttaatctatt attgtaataa cctataaaag
     6661 aactgtaaac atagtcatat actataaagg ctatctcaaa tgaacctata ataaatatgt
     6721 ttattggaat ataaactatt gttcttaata aaaaatacaa tataagtatc attatatttg
     6781 caaatactaa tttcataaaa tactcaatat atatagacct atctttttct ataagatatt
     6841 ttacaatacc atatattcca aaggtaagtg aatatacaat ccattgagac ttacttgcca
     6901 tcactataaa tcctaaaact atagaaccta tataaaaagc aattccactc ttaaagcccc
     6961 attccattat tacaattgat actaaaagtg atgctaaccc cataataaac aatgtattta
     7021 caggaataat atttgtaaga gtcaacaata tcacatttaa tgctaataaa actcctccat
     7081 aagcaacttt tatactcata tttatcatcc taacaacaag ttattaaatc tccaccaaaa
     7141 cattcacaac atgaatctaa acaccaaagc ttagcacaat tttcacaaca atcgtcacct
     7201 agacaacaac agcaatcatc acagcaacag caacaacatc catctaaatc attacgtctt
     7261 cttctattat aattgtcagc cctattgcta taatcatttc tatattgtgt ataacttcta
     7321 agtgcatcac tatattcact attttcaggc tccataaatt ttgctctttt taagaagtct
     7381 tcaccttctt cataatatcc tatgttcatt gcagaaaagc cagttaaata ataccactct
     7441 gcacatttgt cagtcaaagt ttttaaaaaa tcatatgctt ttttaaattc actattttct
     7501 atgaatgctc ttgctctcat aaaattttca ttattataag tattactgta cattctttcc
     7561 acctctactt tctaatatat taatatatct taaataaaca ccagaataaa ttatattttc
     7621 tattattcca acatttttat ttagatttag attatcaatt cccctagcta aaaaccctaa
     7681 tgatgttact attatttttt ttactttttc ttttaactca tcatttttat caatatactc
     7741 tataaatgga ttatatcttc ctttcttaaa atcttcatct aaatcttcat aggcatctag
     7801 tagatatata tacttaccta tattaaaacc tatcattctt aagtttctct cattttcatc
     7861 ttttttatag acaaatactt cacccattat atttccaaat atactagata cttcatctat
     7921 atttatattt ttatcttttt ctaacttatt taattcattt agttgttgtt ttatatactc
     7981 tgctttttca ggatactttt catatgctaa ttttaatttg tttttatata tataatatgc
     8041 caatttatct tttatgcgtt tatcatccat taaattatct tccaatttat aatacgttaa
     8101 aagaatattc atacttgctg catattctgt aatatcattt gtaattacct ttttcttttt
     8161 aaatggattt actatacaca cttcctctgt acttatagac tctgggttat atactgctgt
     8221 taataaaaca attaaaaatg ttatatcata attcaaagaa aacctagaga tttctccatg
     8281 atttcttttt aaatatttac atagtccaca atagtaagct ttgtaataat cgtattctct
     8341 aaatgttaaa tccattttgt ttattttaac atatccaaac ataaatactc ctttttgtac
     8401 tattttttat ttagattata tatagtataa cactttttat caagattata taatttacag
     8461 tattctaaga aacttaaaaa attccttcta atcattgtat cttaaattta aaataattag
     8521 aaggttgggt taaaaataat attaaattat atacttatat taactcatac aagttagttg
     8581 tgcttatatc aatttaagtt ttaaataatt ggtatatatt taaaactacc tacagtatcc
     8641 ttcaattctt tttttgcttt atttataacc aattcatcaa gcattacatc atttattgaa
     8701 catgatatag atttagatgc caataacatt gctttaaatc ccatatcaga acctgcactg
     8761 gcacaagatt gccatgtatg ggcagaaata ccaataggcc aaactgaaca agaacactgt
     8821 gctgtaggaa ttatgtaact aacatctcca atatccaatg ataatgatat acagttatta
     8881 tgagtaaatg tatcatccgt aacttcatca tgcagattca tcttagtaat atccttattt
     8941 ccacttaata cactagaaac actacttctt ttatctatag acactgtctc agctaattta
     9001 tctgcaaaat agtagtcatc ttcattatag ttttgtacac ctactaattt catattttgt
     9061 gatagaatat ctgttaatat tgtatttgga atatagtcat atactccact tataatgtca
     9121 tattccataa tagtaccagt cattaatgct gctccttttg ctatatcaac aatcctacca
     9181 aatacatctc ttacatgctc cattttaact cctcttatgt aataccacac ttctgcaaaa
     9241 tcaggaacta tatttggcat ttttccacca ttagtagtta catagtgtac tctacaatta
     9301 tcaaatatat gttctctcaa ataattacaa cctatattca taagttctac tgcatcaagt
     9361 gcacttcttc cgttataagg agcttgtgct gcatgggcac taatcccatt atatctaaat
     9421 ttcacagagt aattagcaag tgttgggatt cttataggag tatttatatc aaatggatgc
     9481 caactaaaag cacaatcaat tccatcaaaa aaaccttttt ttatcatcaa tacttttcca
     9541 gataaatctt cctctgctgg acatccatag tattttatag tccctttcag cttttttagt
     9601 ttgattaatt cctttactgc aattacagct cctattgaac ctgtacccag taagttatgt
     9661 ccacatccat gacctgcacc accatctaca ataggttctt taatagtgga tactttttga
     9721 gacaaactat ctaaagcatc atattctccc aaaactgcta taactggtct accttctcca
     9781 tagctagccg caaatgctgt atccatacct tctaattcat ctatactaaa accatatttt
     9841 tttaagtatt ctttttgtaa atttgaagca taatattctt tatactgaag ttctggattt
     9901 ttccatatct tatctgatat atctcttaat tctccctgta tctcatctat atattccatc
     9961 aaaaactttt tatttaaatt ctccatatta attatataaa cctccctgtt tctaataact
    10021 tatcgattat cagccaaaat gactaatttt aactgattta aaaatatttt ctatcataca
    10081 accattttat acaataaaac ctcttgactt gtaagtttca ttttatcaag taagaggttt
    10141 tcaagtttta taaaattttt agcatgttaa ccaatcaagc atattaaccc ataatttatt
    10201 atagtatttc caatcagtaa attcttttgg accccagtga ggtgcacagt cagaactaaa
    10261 gatagcagat tttccttttc caaactcgcc aacagctaca aatgggtctc ctccaatagt
    10321 tgctaaaaca ggacaattat ctctagctac tgttttgtta tatcctaaaa actttggcca
    10381 ttctgttggt atacctttta atactggatg tttagagtca ataacttctg gaattattcc
    10441 tgctggtttt tcaactctat catctttatc tatcattgtt attggtaata catctttgat
    10501 agcagtttct ccgaatctag cttttgcatc tattcctgta aatgacatat atccacctac
    10561 catgattaac gccccaccat tatttacata ctctttgatt agttcaagtc tatctggatt
    10621 actattgcaa tctataaaag tactattaga taataagaac gtattagaac ctatatcaga
    10681 taatattata cagtcatact catttaactc ttctaattta tacggaaaac tatctgctgc
    10741 tacatgtgca ggcatatgaa ctgtctcata tcctccagat tctattgctt ctttcaacca
    10801 ctttacagct tcttcataat gagttgtaac aaacgtatca aatcctttta tatgagttat
    10861 attttttacc caagattccc ctactattaa tacttttttc atttatatat tcctcctact
    10921 tttataagtt taatattaga cttgcataca taagtatact atctaaatac tccttaattt
    10981 caacatattc atcaattgaa tgacattgtt ctattgaacc tggccctaat ataagtgttg
    11041 gtatttcagc taaatttttc attaatctcg catcattgcc agctgttgaa ccttttatct
    11101 ctaatttttt ccctagagtt tcttctagta ttttatgtgc attcactaca aaatcagaat
    11161 ccttgtccat ctcaaaacct aaccctgatt gatatatgtt tatatttggt ttattatctt
    11221 taagccataa atctccatta gcccttgtca ttatgacatt tgttacatca tttacaactt
    11281 gttcataact cattatattt ggcaagaagt gtacacataa attaaataca cacttatctg
    11341 gcacagtaga acctgctgtt ccaccattta ttacacctaa atttattgta ggtgaaggta
    11401 atagtggatg tttatatatc ataagccagt tatgttccaa ctcttttata tcttgaagca
    11461 acaacatagc cttctcaatt gcatttacac cctcccactt actaccacag tgaagagaca
    11521 cacctttaac ctcaacttca aagaatacaa atcccatatg tgcaactatt aagttttgtt
    11581 ctgatggttc acaaattatg caacaatctc catcaatacc attcataact gcatttatgg
    11641 taccatttcc gccaccttct tcatctacta ctgacattat ttttacatta ccaggtacat
    11701 ttagaccact atcttttata agctttacag ctaatattga tgctataagt ccagatttca
    11761 tatcagcagt tccaagtcca taaagttttc cattatcttc tgtagcacga tatggattat
    11821 atttccactt acttatatca cctggtggca tagtgtctac atgaccatta aatacaattg
    11881 tcttaccagg taaatcatca ctatacttac aaattaaatt atatctatct tgataattgt
    11941 gacctagatt tccttcttta tatatatttt ttgctttttt aattaattct tcgctcattt
    12001 cttgtctatc tacactaaaa cctatgtaat ttgcaagttt ttcaatatat tcctgtcctt
    12061 ctttttcaaa tccacctagt attccatgac caacatcttc agtctttata cttacaagtt
    12121 cttttaaata atctatgtat tcttgttttt tactatttaa tgtatctaag agaatttttt
    12181 tcatatttcc tcctaagatt tatttttaca tttaaaattt caagtctaat ctcatctatt
    12241 taagccatag taaacttttt cacttagcat attcccattc aatgtataaa gatgtatgca
    12301 aattaaagta taaaaatata tacaaaaact taataatttt tatagtttat aagctaaaat
    12361 ttaattacta tttagattta gctgattttt ttaattttat attatttatc catatagcaa
    12421 ataacattac caaacctttt ataatcattt gattatatga agatacactt aataagttta
    12481 atccatttcc taatattcct attattccga cacctataca tgtacctact atagaaccag
    12541 aaccacccat catattagta ccaccaagca caacggctgc tatagcatcc aattctgctc
    12601 catctccaac agttggtgaa cctgatgcca aacgtgatga tagtattatc ccagctaatg
    12661 ctgttagtag tccagctagt gcgtatactt ttactataac tttatttact tttactccac
    12721 ataatctagc ggcctcttca tttccaccta ctgcatgtac atgacgtcca aaattagttc
    12781 tttttaatag aaaatgtcct gctattacaa ctataatcat aattataact ggtattggta
    12841 ttggtccaat atatcctcta ccgagcatct taaatgcatc tgtatttact gatataggtc
    12901 ttcctcctgt aaatacaaag cttgccccac ttattatcgt taacatggct aaagttacaa
    12961 tgaatggagg tagtttttgt gttgaaataa ttgcaccttt tatgactcct aaaattgtcc
    13021 ctattgctaa tgcaagtatc atacctaccc atataggtgc attataattc actactgttg
    13081 tagcccaaaa tgtacctact aaagcaatta ctgctcctac acttaaatct attcctcctg
    13141 taattattac aaatgtcata cctactgcaa gtattgcatt tattgatatt tgtcttccaa
    13201 cattaattaa attatctaaa gttaaaaagt tagatgaagc tacactcatt attataaaaa
    13261 ttattacaag tcctacagct gcactccctt ggtctctaaa tacacttgtt aattttgtca
    13321 ataatggaga agatttttct tctttatgct tagttattga actcattaat tttacctccg
    13381 aaagccaatt ttaatacatt attttcaacc atttcttcac cttctaaaaa tccacttata
    13441 tgaccttctc tcataaccat tattctgtca ctcattgata ttaattctgg tatttcagaa
    13501 gatatcatta ttatacttac accactctcc actaaatctc ccattagatt gtatatctct
    13561 gccttagcat ttacatctat acctctggtt ggttcatcca taatcaatat atctggttgt
    13621 aataaaagcc atcttgctat tatagctttt tgttggtttc caccacttaa actttgtata
    13681 acttgattca tatgtggtgt ttttatcttt aaagcttcta tgtatttttc taaaatctct
    13741 ttttcctttt ttctatctat aattgattta aacttagata tcttttttaa cccagccata
    13801 gttgtatttt ctttgacact catttgtaaa aacaatccag taccttttct atcttctgtt
    13861 attaatccta gtccattttc tattgcatct gatggagttt taaactttac ttcttcattg
    13921 tttaaatata tttttccaga atcatatgtt ctaagtccaa atatagcttc tactatttca
    13981 cttctcttac ttccaactag tccacctatt cccaatattt caccttttct tatattaaag
    14041 ctaatatcat taaaaacatt gttcttagtt agattttcca ctcgcataat ttcttctttt
    14101 atttctactt ttctttttgg gaaaaattgg tctagctttc tatctatcat taaattaact
    14161 aattcttcct cagacgatac atctttggta tttaaagtcg aaatcgtttt cccatctcgc
    14221 attatagtta ttctgtcaca aatctcaaag agttcttcca tcctatggga tatatatatt
    14281 atactaactc cactctcttt taaatcattt ataagtctaa aaagtatttc agtctctttt
    14341 ttacttattg aagaagtagg ttcatccatt attaatactt tagtttctga tgataaaact
    14401 cttgctattt ctaccatttg tttttgagct atactaagct ctttgactaa actatttgga
    14461 tttatatcta ttcccatatt atcgaaaatc tttttagctt cttcattcat ttttttgtca
    14521 ttggttaaga ctttgccatt tatttctttt cccataaaaa tattttgtgc tactgttaat
    14581 tcgtcaaaaa ctgttagttc ttgatatatg gcatttatac ctatcttttt agagatatct
    14641 ggggatatat tctctatttc tttgccttca aaaataaatt ttccagaagt tttcgaatgt
    14701 gccccagtta aaatctttat cattgttgat ttaccagcac cattttcacc cagtagtgca
    14761 tgaacttcgc catgaaataa ctcaaaatta acattatcta atgctctgac accaggaaat
    14821 tctttagcaa tattacttaa cttcagaatt atattactca taatgacact cctttttaaa
    14881 taggatttct ttcaaataat ctcattttat tttactaatt cttaaagtct tttatatttt
    14941 ccttatcata aagtaaagct ggtactggta tattcttttc taccttttcc ccttttatag
    15001 cttttactac tgcttctaca gctaaacgtc ccatctcttt aggttgttgt tgaatcatag
    15061 caagaatagt tccatctgtt attccacttg atgcttcttc agttaagtca aatcctacaa
    15121 tcttaacatc cttatttttt gcagattcaa gtgcagcttt agctcctagt acactatttt
    15181 cagctgttgc atatattata tctacatctg gattagattg aattaagttt tctactgtat
    15241 taagagattc ttctctgtca tatcctggtt gtgaatttaa tatcttaaca tttgctgaac
    15301 cttttaatgc atctttaaat ccatctattc tctgcatttg tatttgagat tttaaatctg
    15361 tcactattgc tatttctgac tttccaccta acttttcatc tatgtatttt ttagtgtatt
    15421 cccctaattt tttaccagca tcataactaa ctgttcctac ataacttgta atattttcag
    15481 tatttaatac agcatctact gtaactactg gcattttttc aaatgctcct tctactgctg
    15541 gtactatagc cgaattatca gttccaagta ctatcattcc atctacattc tgttgtataa
    15601 aatcttctat tgctgatgtt tgcttagcta catcttggtc tgggtcattt actataactt
    15661 tcacacctaa ttctttagct ttttctttta ttccctcatc aatatctata aaaaattgat
    15721 gttgaagagt tattgtagat actccaatag ttaaatcttt cttgtctgaa ccacctttat
    15781 tatctgattt acttggtcct tccattgaac accctgttaa cattcctatt gctagtattc
    15841 cagcaattcc taaagataaa atttttctca ctctcataat taacctccat ttttaatagt
    15901 tttaaatttg aacaaattag atttttattt attatttaaa tacttttcaa catcttcttt
    15961 atagggcata ccagattgtg cacctagttt agttacagaa agacctgata ctactactgc
    16021 atattctact gctgtatata aatttttccc ttctgttata gccactgcca atgctccatt
    16081 aaatgtatct cctgctcctg tggtatcttg aacatcaaca cttatacaag atacatgctt
    16141 gatttcctca ccatcataaa atctagctcc attttttcct tctgttatta caagtttatt
    16201 tggatatttt tttaatactt cttctatccc ttcatttgtg tcaaaaacta tcttatattc
    16261 atgttcattt ggtgttaagt aagttacttt ttctattata tcttcattta gttttactgc
    16321 tggtgctgga tttaataaaa ccctaatcct attttcaaaa cagaaattca ctacataatt
    16381 tattgttttt aatggaatct ctaattgtag caatactata tctgcattct ttatctcttc
    16441 ttcattcttt ttaattaatt ctatatctac tagctcatta gtccctggta caacaacaat
    16501 actattatca ttttcacata atgttataac agcaacacca gaacttttgt gattatttct
    16561 ggatactaag ctataatcaa ctttattcgt tctaaaattt cttattaact cctctcctaa
    16621 gccatcttcc cctatgcatg atatcatttt tacatttgct cctagtttag aagctgagat
    16681 agcttgatta gccccttttc ctccaggtga tgtaaaaaaa ctattaccta atactgtttc
    16741 tcctttttct ggtcttttat ctacagaaca taccatgtcc atgtttacac ttcctatgac
    16801 aactatattt cccattacat tactccttta catatctatt tatgtctctc gtgctgttat
    16861 tcactttctt ttgttgaatc tcttatgacc aattctggtt tgaaaatcaa ttcatcaaac
    16921 gattcttttt tatctcctct taaacaattt atcaatattt cactggcttt atatcctata
    16981 tcataagacg gctgttttac tgtggtaaga gaagggctta ttagacttga tgtttgaata
    17041 tcatcaaatc ccacgacact tatatcattt ggtatactta atcctctttc tttaagacct
    17101 cttatgacac ctattgcaat caaatcattt gcacaaaata ttgcatcaaa atctatcttt
    17161 tctaaatttt ttataaattc ttgtccccat tcaatcttat attttccttc aaatacataa
    17221 gcaggattgt agcttaaatt acactcgatt agagcctttt tatatccttc taatctatct
    17281 actgctattt cattttgaag tggaccactt aggtatatta ttttcttatt tccaatatct
    17341 aataaatgtt ttgtagctat ataggcccct tcaaagttat ttattttaac aattcctttt
    17401 aaggtttctt tgttcatact tatcttctta tcaatcaaga cagttggtat ttttatatct
    17461 ttataatttg cttctttcca gtttgtattt gaagatgctg caaatataat tccatctatc
    17521 atcctctctg atagtgttct tattccttca tattcttttt tagcatcttc atctgtatta
    17581 cataaaatta tattgtaacc ttcttcatta gctttgtctt ctacacctct tgatacatct
    17641 gtaaagaatg gatttcgtat atctggtata agaagcccta tagtattagt ttttttagtt
    17701 actaaacttt gtgctaattt atttggtaca taattttttt ccttcattat tttcaaaatt
    17761 ttttctcttg ttgcctgact tatattttca tctttattat taatgacttt tgacacagtt
    17821 gttttagaaa caccagccaa ttcgccaatt tcttttatag ttatactcaa gaagttcacc
    17881 cccaaaattt aggaaaccgt tttacttaac cggttaccta gatactatca catctttttt
    17941 ccatttgcaa ccattttata taaattttga tatttttccc ttttttcaaa atattgcaac
    18001 ttataattca attttaatat ttaaattaat ctgcaaaaaa aaattaatat acttttataa
    18061 ttatctaaaa gtatattaat taatttaagc agtatttatt aaagttcaaa tccttgctct
    18121 ataatcattt ttttatcatt ttcaatccca cttccaacag ttgtcaaata atcaccaaca
    18181 attgcagaat ttactccccc attaaatcca actttgtcat atccctttaa tgatagcctt
    18241 ccaccagcat accttatgta cacattagga attataaacc taaatactgc tgttgttttt
    18301 agtatttcca ttggttctaa tacatcataa ttttccattg gtgtattctt aataggattt
    18361 aaaatgttta ttggaaatga ttttacattt aattctcgta tttcaaaagc catttttagt
    18421 ctctgttctt cactctcatt cattccaatt ataccaccta cacatacatc tagcccagct
    18481 tttttagcat cttttatagt ttttatccta tctttatatg tgtgtgttgt acatatatta
    18541 tgaaaattat ctctacacgt ctcaacattg tggtgatatg tagtcacacc tgctgacttc
    18601 aacattttag cttgctcata atctataata cctaaagatg cacataattt taaattagta
    18661 ttttccctca atccttcata gatatttaaa atattattaa actcctttcc tgacatacct
    18721 ttaccacttg taaccaatga gaatctatgc actcctttac tctccatctc tttagctcta
    18781 tttaagattt cattgtaatc taataatgaa tattcttcta caccagtttt ataatgagat
    18841 gattgagcac aaaatttaca gtcttcacta catttgccag atttagcatt cattatcgta
    18901 cataaatctg cttttcttcc cataaaatat tctcttattt catttgcaga ttttaataga
    18961 atatcaaaat cgtttttatt atttgtatca aggcttatta aattaagagc ttcttcataa
    19021 cttatttctt tttctctcaa tactttattt tttaatttta ttatgtattt ttccatatat
    19081 cctcctattt gtcaacttaa tatttttatg tagtttactt attatatata gtattgcata
    19141 tataacattt attggtcaac tttattttag acacaagttt actatacaca aaaaaatact
    19201 gcttcaaaat aatattagta aatggattat acatattatt attaaaacag tattttttat
    19261 tagaatataa ttcttactgg tttataaaac tatccttgtc ttaactccat ccaagctttc
    19321 cattgtaata acctctaagc cttcatattc tctaaatagc cattttaaat ccttcatggc
    19381 ttgattaacc tgactttttg ttagattatt tataaaatat tcttttctag tttcctcata
    19441 ctctttgcta gtcaaaaagt ttcttagaaa attaaacgca aatacacttg gaatattgtt
    19501 tacattagcc ttcttgctgt tttccttctc atagtaaatt ttcataaatg catactcctt
    19561 tgatactttt agatttctct tacaataatt atatgcattt aagtgctact attcttataa
    19621 ttttattaat tcatattctt tacttcccat acccatttca catgcatagt ctattattct
    19681 agttccattt acatgaggat gttcatgttt gaaaacatca tgacccattt ccttacaaat
    19741 caaatcatag catgcttgtt caatagctac agggtctgtt gatgctaata ttcctatatc
    19801 atgggcaatt ggtctacctg accaaggtac acaatcacaa agtggagtta cattcataac
    19861 aaaagttata taccctacct tgtctttttt atttgatact gctccataag cgtattctgc
    19921 catcttttcg acaaacacat ctgagtcact ttcccattgt atagttactg ctctagttgg
    19981 acagacagtt ggacattctc cacatccata acatacatca gaatctataa ctgctttttt
    20041 atccactata cttatagctt ttgtaggaca agaattaaca cactttccac aacctacaca
    20101 cttcttttcc tttactactg gagtaacatc agaatgttgc atttgttttc ctgctgcact
    20161 tgcacatccc atagctaagt tttttaatgc tcctccaaaa cctgctgctt catgaccttt
    20221 aaaatgactc attactatca ttgcagaaga attataaatt tctccaccta tttttacact
    20281 ttcaaaatgt tttttgtcta tttttacatt ctcataattt ctactatata atccatctgc
    20341 aattattact ggtgcattta caactgcata agcaaatcca ttttctatag cagttgtaag
    20401 atggtctaca gaatttgttc tactccctgt atacagtgta tttgtatctg ttaaaaatgg
    20461 ctttccttcg cagtctttaa ccttatcaac cacttgtcta actgccacag gactcatata
    20521 tgtagtattt cccttttctc caaagtgaag tttaattgca acttggtcat tcttttctat
    20581 taaatctttg aatcctgctt catcaaataa tcttcttaca ttgtttggta cgtttttatt
    20641 ttgcgaattt gagtataaat cacaaaaata tacttttgac ttttccatat ctacacccct
    20701 ttaaaatatt tacttatact aattttatca cttttaaagt aatttttagt atattttaac
    20761 ataattaaat attcttatat ttatttgata caaataatat tatttgtatt attttctaca
    20821 cttaattcta tatattaaaa atcaaaaaga cttgaaactt aagtccaagt ctttttgatt
    20881 tttaggtgta gtttttaaca acataagatt actttacctt gtgataaagg tattattaaa
    20941 ctggtttttt attaaataaa ataacagctg ctagtaaaca tactacagaa ataagaactg
    21001 ttataataat tggaataata aattctggca ttgccacttt ccctgaaatc aagtctatat
    21061 tttttgacat caagaaatta ggagtataag gtgcaatctg tttaggaata gaaattaaac
    21121 tcaataaaag agttgccacc aatacaagta aaacactggc aaatgctggt ctaaatagta
    21181 cacacccaag aattaataca ctaatataca taattcctat aagccataaa ttaaatgctg
    21241 aaaatataat atgattaaga tttgcagttg gccaaaaata tattgtatag ccataagcaa
    21301 ataaaaaact caaccaaaaa ccaattgtca taataatcac cgtaacagag aatttagaca
    21361 atactataga tgaacgtgat aaacctttag tcagcataat aacaagtgtc cctttagaat
    21421 attcatttga taaaatatta caaaaaataa ttagagttaa actcatacca agaccagaga
    21481 tattgctaaa aaattgtgtc caagaatcta aagcagttgg tgcagcagta acttttaaag
    21541 tcggtgcaaa atgagcaatc aagtctggca taaattttgc agaaatagga ctacttatac
    21601 caaatattag aaataaaata attaaactaa ataatttata atttcttaaa ttctctttaa
    21661 attctttttt tgtaaatgct atgtattctc tcactttact acctccaaaa ataaattttc
    21721 aagtgataat tctattagtt ccatctttac tggacaaaga ttcatttctg cgagtgtaga
    21781 tataactgtt ttttgtattg cttttatatc tttaccatgc aaaacaattt ccatattagt
    21841 ttcttctgaa tcttttagta aggatttaat accatcacta gacttaaact tttgaatttc
    21901 atcattactt gcaaactcca gtaaaagtct atcctttccg tgcatacttt ttatttctga
    21961 aagtgtacca ctaagggcaa tgcttccttt gtttaatata gcaacatggt cacagattct
    22021 ttcaacatct gatagtatat gtgttgaaaa tattacagtt gttgagtctt tgattttaag
    22081 cataatatct aatatttctt ttcgaccaac agggtcaagt gcacttgttg gttcatcaca
    22141 aataagtaat ttggggcgtg aaagcaaagc ttgagctata ccaagtcgtt gcttcattcc
    22201 acgagaaaac ccacctattc gtctcttttc atttccaaga cccacaagtg ataacaactc
    22261 ttcactcctt atctgtattt ctttttttga aagtcccgta atttcaccac aaagagaaag
    22321 atattcaagt ggtctcatat agttgtaaaa ctctggaaca tcaggcagat aacctacatg
    22381 acgattagaa cttgttttcc cataggtcac tttctcacca caaacatcta tagttccact
    22441 atctggttta agtaacccaa gtaccatttt cattgttgta gtcttacctg caccattctt
    22501 acctacaaac ccaaagactg acccttctgg tacagtaaaa tttaaattat ctattatctt
    22561 tcgattacca aaaccttttg ataatccatt tattgagaca atattcatca ttcttcacct
    22621 cttcctattg taaaatacaa aattggtcct attagactaa taaacagtac tacaataatc
    22681 catattgcct tatttccaat tttataattt ggatgtctca atacatgaac aagtgcagta
    22741 attataagta ttaaatctaa aataataaca ggaaccaaaa gtggtaagta ttccatcaaa
    22801 ttttccataa tcttattcct ccaataaaga taatttttct ataagaaatt tgtattcttt
    22861 gttttcactt aatacagaaa acattggatt atttttaata gcagcaacaa tacctgcttt
    22921 tacgattgta tcatcacgtg taatacctgt tccaatttca gaaatccatc tgtcaagttt
    22981 attaaaaaag tcatccccat gtattataat tgggtatata tcacgtgttg ctaaatctac
    23041 atattttcgt aatgatttaa tagctccttc attatcacca tgtattaaat taatttgtgc
    23101 ctgtgttaaa tatgaagaaa gcataatagc aggagataat gtatcaagct caaatatatc
    23161 tgaaattgct agaatacgtc tttctatttc cttcatttgt aatttatctg cattttgcaa
    23221 aatacccact aggttttgga ctaatgatat aaggttctga tatgcaccaa gttgaaatgt
    23281 ttctctcgct tcatccattt gaccattcat catttgcccc tgtgcaagaa gtatagattc
    23341 atttatcatg ggaaaattgc tgttttgcaa taaatcaatc acttgtatgg gttgatttaa
    23401 caatatataa caagttgcct ccatactttt tgcttgacgg caaatatcta tgtcattaca
    23461 agtttcctgt atacgaataa atatttctaa tgcttcacta attaatagtt cacgcttttt
    23521 ttcatctaca atatcatagt gattaactat taaaagaccc atccgaaaaa tcaaaggaaa
    23581 acatgaataa tattttttta tgatttctct tatttcatcc atgacttcat caaatggttt
    23641 aaccgtaaag tctttgcaca gtttattata cagtttatta atatcttcct tcatcatttg
    23701 aggttcataa catattaact catcaacggt aatgttgaaa tatgtcgcga gttgcggtaa
    23761 aaaagttatg tcaggatagc tttgtccagt ttcccattta gatacagaag ctttagaaac
    23821 gcctatataa tttgcaagtt catcttgtgt aattcctttt tctttacgct ttaaaatcag
    23881 cgtttttgcg atgtttaatt cattcatgtc aatccctcct tatgtataat tatatcctta
    23941 aacatgtaaa gctaacaagc gatttgaagt tgacttttga cgaaaaaatc aaccacagag
    24001 aaacaaataa acaagtatat aaaatatata tttaaattta tctttaatct cttttgtaaa
    24061 atatgtaaac tttgtaaata aaatccatat tatataaaac taatagttaa tctatctaaa
    24121 tacagttttt atttatcacg tttttaaata ttttgtgtaa aacctctttt aatataaaca
    24181 ccttattttc atttctcatt tcatattctt tttaaaatac tgaatataac tcttcgattt
    24241 tccatttaat tcttttataa agttattatt cgtatttatt tctctaatta taacaggcaa
    24301 ctatcatgta ttggtatttg tctattatat aaaaatctat aaaagaaaag cagtcaatca
    24361 tttagattaa ctgcttgtac atatatctta ttaaactgta taaactataa tttttattat
    24421 tctccatttt catcccaagt cataaatccc catccactat ctggataagt atcaatagac
    24481 ttttctctaa tcatataacc aactttataa cactcttttg ttattttatt agatagtata
    24541 catccttctc catttatcta attccattca attaactttt cttttcaacc ttaactttta
    24601 taaaatcatc ttttttaata atttcatact tattttctct tcaacatcat caaatgaggg
    24661 tgtctcaaaa ttaacttttt acttcataag gcactctttt ttgtatgaag taaaatatat
    24721 tttcatcatt tcaacaataa gtaagaggct tatctctatt ttgagacagc cccatttgat
    24781 ggtgttgaac atttaaataa ggttgaactc gttttatctc tctttttaag atatctgtaa
    24841 atttgcacat aaagtctctt cttcttttac aattctaata gttttattaa agccaaagta
    24901 tatatctcca tattctttcg tatatgattt attggtactc tttcatctac tccatgacca
    24961 ccagttttat acgctaagaa cttaggtcca aacgccacca tatctttaaa ccaacttgca
    25021 tatgtgccac cacccatagc aattgtatat ccattttcat ctgttacttc ttcataggct
    25081 tctaataatt ttttaagtac taaattactc tcatccacat aatgtaagtc tttatgagca
    25141 ataacctcta ttttccaacc attacaaaaa acctttttga atctatctat tatattgttt
    25201 aaaactatat ttttaccata ccttatatct aactcacata cgattttttc ctcatttact
    25261 tttaatattc ctaaatttaa ggtagtgttt ttgaatacct catcatattg attaatccct
    25321 aatgcatctc cataataatc actacaaagg tattttgaaa ctaattcgat atcttctcta
    25381 tgctgaaaat ccatattatc ctcaactatc tttattacca ttttagatat agcattttct
    25441 cccttttcag gattacttgc atgtacagct actcctttag tagttaactc tgaaataatt
    25501 ccattaataa tttttgcagt acaatgagat ggaacaacat tttctttagt tcctcccctt
    25561 actattatgt aaggtttact tttgtcaatt ttaatttctt tttctatcct tatatgaacc
    25621 cttccttttt ctccattaac cactggatac atagcatctg gagtaaatcc catacttgga
    25681 atttcttcac ctttatctaa gtaatatttg atacatttca tacctgtctc ctcatttgta
    25741 ccaaaaatta atcttattct tttattaatt gtaggataca tatcctctat gtttttcaat
    25801 acatgtataa gcatagatac agcaccctta ttatctatta cacctcttcc ataaataata
    25861 ttgtcaatta ctgctcccga aaatgggtct acactccacc cctctcctgg tggaactata
    25921 tctaaatgca ttggaatccc tattaattcc tctccctctc caatttctgc atatccaata
    25981 taattatcaa tatttttaac actaaaacct aaactagcac agtaatctaa agttttatct
    26041 aaagattttt taggtcctat accaaaagga cattgtgaaa taggttcacc ttgttgtgaa
    26101 tcaattttta tcaattcttt tagaaattct atggttctat ttaaactatt atctacactt
    26161 ctgcttatat ccataaatca acctactttc tatcttttta aagcctgtcc ttaaagaaca
    26221 ggcttttagc attaaaaatt atttttttgt aaatactaat tcacaaactt catcatcatg
    26281 agcacatttt tgagcaaaat ctaatttaac accttgtgcg cagtcaactc ttccataatc
    26341 cccataacaa gctaatctac aaatttcttt tctttcttct ttagttaatc catattcttt
    26401 ccaagcagca tctaatggac agtgatggaa ttttaaaacg ccattctcat ctgtattttc
    26461 tactaattcc atttcaaaca ctttttgtcc tttactgtta tataacattt ctgccatttt
    26521 tcctggagta tctgctacgt tatatttttg acctctcatt ttaccaaatc catatattgc
    26581 ttctttacat atatcatctg gattagctcc taatttttca gcttctttca taagaagata
    26641 gaaccatact gctctttctc ctgttgctcc tctaattcct tctaaatatt ccttttctgt
    26701 atacattttt tctgacattt ctttctcctc ctaaaattaa attctatatt ttaatcactg
    26761 tgaattagaa tattccaatg aatgacccta ccaatgctaa tacaactaaa attactaata
    26821 acttagttat tgtccacttc ttgtatttca ttccccaata tacgaagaat acaacaccaa
    26881 gtggtaataa acctggagca atcatattta atgtatcttg aacaacaatt gctttaccac
    26941 caatatcaaa tgatagcgga gttgaaagct taactgtagt tgcagataat gctcccatca
    27001 taaacattcc tagaattgaa gcaccatcaa ttatcttatt gacaatacca cctgatagaa
    27061 ttttcttaat tgaatctcta cctaaagaat atcctaaatg aaataagtaa taaccttcgc
    27121 aaaatagtaa tatactaaac attattggga aaaatgcacc tataacactt ccttctgctc
    27181 caaatgaagc acctaaagct aagaatattg tttgaaatgt accaaaatct aaagtatctc
    27241 caattccagc caaaggtccc ataagaccat tcttaacacc tgaaataact tctcctggga
    27301 tttttccttc agtagctttc tcttcttcca tagctaaaac tgtaccgtga attaatcctc
    27361 cccatatagc ttgagtatta aaaaattgta agtgtctctt taacgcatct actaaatctt
    27421 cttttctctt atataacttt tctaaagccg gagtgaaact tgcacaaact gctaatgctt
    27481 gcattctttc aaaagagttg gataattctg ctgtccacca ccatcttaga tatgtttttg
    27541 ttacatcttt ctttgtaagt actcttgtct tattaacttc agttggacct tgtccatttt
    27601 taacttcttt attttttatt tcttgcatta tacttcacct acccttttgt cttctttcat
    27661 aaaggtaatt aaaagagcta tacaaacacc aaatattgca gctgcagtaa ttgatatttc
    27721 aaaatattga accataaaaa atcctataat aaacattggt aaaaatttat ttttacctat
    27781 agtaaatatt gttgttgcaa aacctaatgc aggtaatata ccgcccatta ctgttaatcc
    27841 attcattaac cattgtggta taacatctaa taatgattga actaaatctg ctccaaaaaa
    27901 gttacataca aaaactattg gaaaccttaa aacaaaccca aatattaaag aataaagtgt
    27961 tgcacatctc cagatgcctt ttgtattacc ttcttcagca tacttatctg ccttatgaac
    28021 caatacagca ttaccagttc ttcttaagtt attaactaat actcctataa cacctaaagg
    28081 taccgcaata gatactgcaa cttctgcatt aacaccagtt tgaagtgcta ctggtattgc
    28141 aataagagca gctagacatt tatctgatgg aatatttccc cctgctgcga ccattcctag
    28201 ataaaccatt tctatacttg caccaacaat cataccagtt gttacatcac cccaaagtaa
    28261 tccaaggcta aaacctataa ataaaggaga ctttagtgtt gagaaaaggg tataccctgc
    28321 aagacctgct gcaaaccaat accataatcc tgttacaatt gccaacatca aaacagattc
    28381 catttataat tcctcctaat ttatattttt tatttaaatt tctttaacgc attttcatat
    28441 gtcatagatg attcctctgg tataacttgt aggactattt caaccccatt ttcattaagt
    28501 tcattaagtt gttctacatc ctcatttcct aatgaaacag ctgtaaacac cattttcttt
    28561 cctgcttcat ttggaatacc tcctaattga atcttttcat atttaagtcc agctttataa
    28621 gccttatttg ccatatcaac atttttaaat agaataaata tatttttatc tcctaaagtg
    28681 ttgttttgga atgcttgtcc cgcatcttct gctgttaaaa taactacttc tactcctgat
    28741 ggtgctgcca ttttatatat gtcagccata aattcatctt gacctaagaa gtcatcaact
    28801 attattattt tttgagcttg agcgattttt acccattttg ttataacttg cccatgaatt
    28861 aatctgtggt ctactcttac taatgttatt tttgccatta tattcacctc ataatttata
    28921 tttttttaaa ttctttaatt aaatccacac aaaggttatt attttttttg acgattcttt
    28981 ctggtaatgt atgtaattta tcttctttgc ttaattcttc atctacgatt aaaattgtct
    29041 gtaagctaag tccatttatt gcatctattc ctcttcttat agcaacagct attgcaacac
    29101 ttgatgtaga tcctccatat aaatctgata ttataatttt cacatcttct ttatctacta
    29161 cttcttcaac ctctttcata aatacagaaa catctttttc agaacttagt gataaaactt
    29221 catattgatt tgacaatcca aagtttttat ttgtttcttc tactaagact tttccccaag
    29281 ttccatggca cagtatgatt accttatatt tattcattgc taaataaact ctcctttata
    29341 gcgattaata ttttggttta attctacttc ttcttcatca ggtaccattt gaattgatac
    29401 attaatattc tttttaataa attcatctat taaaagaaac tcttttttat taatgtatac
    29461 attttgagat attttctttt ttcctattcc tgtaggtatt cttccaacaa taagtttttt
    29521 gatattaatc ccttcttcta tcattctatt tgcagtatct aaatttttaa ttaatacaaa
    29581 aacgttatca tcagcttgat tattataaaa atatctcctt gattcactta cagttaatat
    29641 tgataaatca atattctttg gtgctgccat ttttatcaaa cctttagcaa taacatcatt
    29701 ggttgtttca tcatctacta ctactatctt ttttacacct agatgcttaa cccatttata
    29761 tataacttga ccatgtatta atctatcatc acatctgcaa tattttacta aagacatttt
    29821 taatcaaact cctttttcta ttacattgag ctaagaactt tgttaatatt gtttatacca
    29881 gtttgtcctg cttcaataca tgcttctgct aactcttcta aactttttcc ctctctatta
    29941 attaaagctt caagtagcat tggaagattt actccagtaa gtgcatgaaa cttgccacct
    30001 tttttaaggt ttaaacttgc aacattactt ggcgaacctc ctaataggtc agctaatact
    30061 aaaactccgt caccttcatc taattcattt aacttttcta caaaattttt atttaagtct
    30121 tcaatattat cattcctatt tagtttaatt gctgctgttc tttctgctgg tcctgcaata
    30181 agttcacagc tttttataat ttcttcacta aaactcccat gagtcataac tattattcct
    30241 atcaccaatt tcacctcact tttcttgtca ctttttatat aagcaattgc cgtgccaact
    30301 tatgtgtatc aataacaaat ggctatttta caggatttaa tcaaaacttt ttattcaatt
    30361 ttttttaaaa acttattatt tcgatatgta tcaaaagatt ttttcaacct gtatcaaatc
    30421 tgtatcaaaa aaagtaaaaa aaagatagcc ttttggctat ttttaaattt tgtatcaact
    30481 tttgaattta tctgtatcat attgtgattc aaatatatct aatatatttg catattccat
    30541 atctgaaata attatatcga atgtctcttc tactagctta aaactttctt ttataactaa
    30601 atataattct ttatttctac taattctttc ttcatatgat ttataaacta aagactcttt
    30661 tattattact ctttcaatca tacatgaaca atgaaatata aactttacta aaagttcatc
    30721 ttgaattact aaagaatagt gttcactaat tctattaatt acttctttta atataaaata
    30781 agccttttcc ccatttaaaa aagtcaaagt tttactaata ttatcaatta gtaatctatc
    30841 aaaatatcta ccaccattat ctttttcagc atatgtaact tccatatctc cataatgttt
    30901 ctttatagat tctataatat taaaatataa tttctctaat gtcatttctg gagttagagc
    30961 ctttctagtt gcttctatta caataggtgt acttaccata tctattgctt ttacttcttt
    31021 tcctgtagca tcacgaataa ctttagcaaa tgttaaaata gaccccatat cagttaaaat
    31081 taaaattccc tttcctttat caattttatt ggctatttct acagcttgta ctaaaatatc
    31141 ctgaactcta tcttctaatc ccatattaat tgccactgca tggttacaat ccagtaaagt
    31201 attggctaca ttcaccatgc tagatgctgt agattcacca tgcattatga ctaatattgc
    31261 tatactctcc tcatttaatc ccacatacga taaataaaga aatgttgcta aaaaaattgc
    31321 ttcatcttct ggaaactcta ctccatacat taatgacatg ttagataata tttcttttgc
    31381 tatgttatat tcatatgctc tttccttcat aatttcatct ttattaggat gctttactat
    31441 atttccaatc tttattcttt caattaaatt ctgaatatgt aaagctatag cttttattaa
    31501 tttatctaat ccttctcttt tgctccattt atcatgcttt tgtaaaatat attttacagt
    31561 agttgcaatt gaatcattaa caatgttgtt ataagctgtt tgattactac tattatatat
    31621 aaaagtattc attaaattat aggaatactt ctgtatgtct ccatctataa cacttctaat
    31681 ttgtgactct ttaatacctt cttgttgaag tttattccaa gtttctttta tcattccata
    31741 aaaatctaaa tcatattttt tattttctat taataaattt tcactttcaa aatccttttc
    31801 ttctggtaaa aaaataatat catcttttcc aataaaactg aaattttgta caaactcctc
    31861 ttttctatta tttccatata atgattctct aatattattt ggtagaagag agagccttac
    31921 atatacacat tcccttttat aggtcatata atctaaaaaa gctcttgcac aaattaattg
    31981 tatatcgctt tttaattggc ctatgtttcc cttacactta tataaaataa atgccttaat
    32041 aacttctttt gaaaccttta acttaacacc aatcctaaca ctctcttctt taaaaaaata
    32101 acatataagc ttcattctct cttgaaagcc tctttcctct aaagacggaa tctttatagt
    32161 tacaggtatt cttcttaaaa acgtttccaa cattgctgtt tctgggtctt ctgtagtggc
    32221 tgcaattatc ataactctac actcgtgtac cttattagcc tctcctaacc ttctatatat
    32281 ccctttatcc ataagcagaa atagcatttc ttgtccctct gcagataatc tatgaacttc
    32341 atctaaaaac aatactccat tattagcttc atgtacaata ccatacttat ctttatcagc
    32401 tccagtaaat gctcctttta catatccaaa aagctgcgct aataataatt gctgattatc
    32461 agaataatca gcacagttaa atatgataaa tggtgcatta tcactatctt cttttatagt
    32521 taaactatac ttatacatat attctgcaaa tatagattta ccaactcctg taggtcctat
    32581 tattaatgta ctcaacccct taggtggata tattactgct gctttagcct gttctatttg
    32641 ggatcttaaa cttccatcac atcctactaa attaaaaata ttgttctctt tttttatact
    32701 ctctaaaata tactcatctt tgatagaatc attttcacta tattcgttta tagagttaat
    32761 attatcaaat atccctttat ttagtttctt tcctaaaata ctctcaatac tttctttata
    32821 taagtactga acaggcttac cctttatctt tataatgata ctttctttta ttaattgatt
    32881 taattcctta ctagcattac ttctatttat acctacttca gtagctatat attctgcatc
    32941 aaatccaaat ctaatgccat tattaaagtt caagtgttct tctgttaacc ttttcaagca
    33001 aattaaaact ttttctttcc ttgatagctt cttttgtgtc atagttaacc tcccctataa
    33061 gcagtaatac tgttaaacat ttattattaa gcttaattct acaatatttt aatatttttg
    33121 tctaattatg taactattga ttttctttcc tattcgtttt ataatataaa ttacgttacc
    33181 ctcatctttt atagaggagg aatttatatg aattttttat cagatttaca cacccactct
    33241 atagtcagtg gtcatggcta tagcacttta ctagaaaata ttaattattg taaagaaaat
    33301 ggaattaaga tactaggtac atctgaacat ggtcctaaga tgcctggttc tccccacaga
    33361 tggtactttc acaacattca aaatatccca agaatcataa ataacattat aattttaaga
    33421 ggctgtgaag caaatatact agatattaaa ggaaacatag acctagagcc ttttgtaatt
    33481 cctcggttag attatcttat cttgtcattt cacgaagctg tgttttctcc aaatacatta
    33541 gagaataata ctaaagcttt aataaatgca ataaataagc atgataatat tgaaatatta
    33601 ggacaccttg gaaacccaaa ctacccaatc gactatgaat taatcattaa attagctata
    33661 gaaaagaata tcttaataga aataaataat tgttctatta aaggcgtgtc aagaaatggt
    33721 agctcggata actgtaagta tattgctaca ctttgcaaaa aatatggtgc taaaatcata
    33781 ctaacttcag atgctcacat ttgttttgac ataggtaact atgagtattc tgaaaatatc
    33841 ttaaaggaaa ttaattttcc agatgaatta ataatgaatt atcctaaaaa acttattaat
    33901 cattttcatc aaaaaggtaa attactagat gttgattata caaatatcta agtaataata
    33961 catgcttact ttaactccca taaaaatttt aatactattt atattatatg aaataaagaa
    34021 attataataa agaagctatt taataaagct taattacttt tatgaacttg atggattgat
    34081 atggtctatg atagcaatag aaattataac atttttaata agcttagttt tatatacctt
    34141 atagtataaa gctaaaaaaa agaatcatct aaaataaagt aaatcttata taaggtttac
    34201 tttattttta tttgtaataa tcatcaatac aaattatttt attatatgta attatttatg
    34261 tcttaaccaa ttttatcgaa aataacagtc ttctctttta aagagatttt tcctacttga
    34321 tatccatatt catttaattc ctttttatat ttcaaaaacg aatggtctat ctctatccca
    34381 gcaatatctt ttatttcttc aaaagttaat ttaaacgatt gactattgtt tttcttaaca
    34441 tattcccata aagaactata tttactcatc ttatatcact ccttttaaaa tcatatctta
    34501 tctattaatt tatattctat cattattaat gtataaagtc atgctactta ttatttatat
    34561 ataaaaatat ccaaataata agtagcaatt ttttatagtc ataatatttt tttcagatta
    34621 aataaaaatc aattatagtt aaaatatttt ttaaaagaaa tctatcccat tataaagtaa
    34681 attttaatta tcttatttct agtatgtaat tattcaaaat agtatatcat tattgaaata
    34741 cacatctaat aactaaaaat ttttacatat tcattagtta aaaatctttt tattgcattt
    34801 aaattaaatc tatcaatatt tcagtaataa cgttttctta attttcgcta tggatgtcga
    34861 ttcaattata attaaagctc tacatcaatc tttttaccac tcattgaaca acaactaact
    34921 tttgccttat caatagagaa tatttcaaac ttaccatctc ctacagagta catctgacct
    34981 aaacttggca ttatttcaag tgccttagct tgtgtttctt ttgatgtaac aaatactgct
    35041 tcacctaaaa tacgtagagt attaaggttt tggtctatac aacaaagttc aacctttgga
    35101 ttaaaaataa gttgcttaaa catatccttt tgattagatg tgcaaaatgt aagtttacca
    35161 ttgtattcca taacaaatcc taaaggacgc acatgtgctt gattgttctc atcaactgtt
    35221 gctaaataat aaactcctgc cttgttcaaa aattctaatg ctttcataat tcttacaccc
    35281 cttttaaata cttgtattaa ggattatcct ttgatataat tttaatataa aatacagaaa
    35341 aaacaagtat gcagtttttt ctgataaagt ataaaaaaga tactactata actaaggagt
    35401 aattaaaatg agtataaata ctgaaaaaaa tataactaaa aacgttgaag aattaacctg
    35461 tccaatccgt tatgcattag acattgtcgg tggtaagtgg aaattaccta ttatatgtat
    35521 gttagcagtt gaaaatccaa ttagatatag tagcataaaa agaaaattgg atggcattac
    35581 aaatactatg ctagctcaat cattaaaaga tttagagtct actggtattg ttcatcgtaa
    35641 acaatataat gaaattcctc caaaagttga atatacatta acaagtaaag gtaaaagtat
    35701 tgtgcctatt ttacaacaat ttgctaattg gggtgctact aatatgcaag aaaaaaacac
    35761 atgtggactt agttgcaaag aatgtagaaa gataaagtaa atttaaattt actaaattat
    35821 tcatattata gactatatat taatttatct gattgaatat aaaaacagga tgacttatat
    35881 attcatcctg ttctatatgt taagctctaa atttaattag ttcaagcata tcgtttaata
    35941 ccaataaact atctacttga atcattagcc atttacttcc attaaaaaag tttacctcat
    36001 tatatatttt tttgatataa tcacaacaag tattaataaa taaatcaacc tctactctat
    36061 tgctttcact tacaataacc aaagctttaa aataaccttc ttgtggatat aaagtacata
    36121 gtgatttacc tcttttttta tattttacat tccaacctct ttgcattgaa catttactgt
    36181 attcaagctt aggttctaca ttataagtag aaaccaaagt tttatttaac ttgtcccata
    36241 atggattatt aataaattca ttaatttgct caaatgtagg tttagtatct tgaaaaaacg
    36301 catcttgcca attcatattc atcatccttt ctattgttca ataggaaccg gaacaatcca
    36361 atgttccaga tatgctgctt caggtgtagt ggggtaatac atctcaattg caaaatcagt
    36421 agttgttaaa ttatgtttct tcatccatct ttccataaat ttatctgctt taaaaacagc
    36481 tgaattaact aactcattaa agttttctgc ctcaaatcca catactaaat attctttagc
    36541 tggcaactca aaagtactat atccttctac tgatgtacct gactctacct ctacacctgc
    36601 catatacata caatttcctt cttttgcatt tcccatataa agagcagcaa attcatttcc
    36661 acctggaatt tgatttggta tattatgtct ttgacttcca agtttcatcc ataattcctc
    36721 tactattgca attccagttg tttcaccgcc caccaactgg caaataggta cttctatttc
    36781 tattccaaca aatgtccttg gattactcaa tgtcttacga ttgacttcaa tcactatatc
    36841 atctgcaatc agtggaacac cttcatcaac catagcataa tttaaaatta attctggctt
    36901 aataaaatga ttgagtttta ctggatttgc tctatatttt tctggagtta atccatatgc
    36961 ttttttaaag gaacgtgtaa atgtctcatg actagcaaat ccaaaattta aagctacatc
    37021 aagtatacga ttcttatgtt ctgctaagta ttcagaagct cttgcaagac gacgaagctt
    37081 tatatactcc attacagtct tatttaccaa tcttttaaat agtctttgat agtaaaatgg
    37141 tgataaattt gctttatttg ctaattcatt aattgatatt tcttctgata aatttgcttc
    37201 tattaaatcc aatgtaattt gaatagactc ccatgcatgc atactataac tcctcctgat
    37261 atttttgtta ctcttatcct ttatagtatc aaaactagaa aaaatgttct tgatagatag
    37321 tgcccttttt aattttctta tatgataatg ctaaatctca ttgctttatt ataaacataa
    37381 aatatataaa aataaaatat agcaaatctt taggtaagat ttgctatatt atatatttta
    37441 ttaaactatt tttaaatact ccatttattt ccttaagaaa gaactctttc atatcatcta
    37501 attgttcttt atcatacacg tacttaccat atccaaattg accgtattta aactttctat
    37561 cttcattttc cattggcaat agtgtatctg gataaatctc tagtattcta ttttttgctt
    37621 tagttgtata tctatgagat ataacttcaa atataatttt tttatcaaaa tcctttggta
    37681 aagcttcttt tatacttata atcagatttt tatactcttc tttccaacct tcatataaaa
    37741 acacaggtgc tattatgaaa ccaatctgat aaccagccct agcaagtttt acagctgact
    37801 ctattctttt atttgcagag gctgtataat gctcatgttc atttataatt ctaggagtat
    37861 tgatactaaa tcgtatttct gtatgattat tatgttcagc atccaataag ctatccacat
    37921 cactgtattt agtaacaaat ctaaatcttc ctttttcctc tcttccaaaa aactctattg
    37981 ttttcttcaa agaattagta tatggctcta ctggaactgg gtctgatgta gctgcccctt
    38041 caaatatggt tacctgtggc tttctatctt caatatattt ttttgtctgt tcaagtattt
    38101 catctacatt tacaaacacc cttataaatg gtttatcacc taattgtgtg ttcaaataac
    38161 aatactcaca tcttcccata catccactga caagtggtag ttgataatta gcagaaggtt
    38221 tacatgtttg aaacttcaga ctttttctaa tcccaactac catagtctgc ttcccacttc
    38281 tatattgttc atatagattt tcacctggaa tatgttcttt aatcctattt gatgatatat
    38341 taattatctc tacatcttta ttatctctaa atttattgta tattttttta cccacatcag
    38401 tgtctaaagt tcctttttcg aatattattc ttttgggatt aaacatttat ttcacctcta
    38461 cttaaagttt ttaaatcgaa gaattttata aaatattact taattaatct tccctttttt
    38521 aaactccttt atttattaga aagtaaaata aaagcttaag acaaatt
//
LOCUS       DAEHWM010000031        38147 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.032, whole genome shotgun sequence.
ACCESSION   DAEHWM010000031 DAEHWM010000000
VERSION     DAEHWM010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 38147)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 38147)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..38147
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.032"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(110..514)
                     /locus_tag="KNP36_001649"
     CDS             complement(110..514)
                     /locus_tag="KNP36_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="HBF0873527.1"
                     /translation="MKKYKVIFIVLIIGIISVTGFVVYKNCIKPWKDAETYIDKYMVK
                     QDISKDNIKSITKEKAKKASYEGILYKVYYKDDPRYEYQYFYSDNYYALYVNKVMLQI
                     YDMENNNKLLRSNEELKSVKYPPIYLKYKPDK"
     gene            complement(706..1893)
                     /locus_tag="KNP36_001650"
     CDS             complement(706..1893)
                     /locus_tag="KNP36_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosyltransferase"
                     /protein_id="HBF0873528.1"
                     /translation="MSKIVFFSIPAYGHTNPTIEVVRELVDRGNEVLYYSFNEFKDKI
                     EGAGAKFICCDKYLPELLPGDEKKIGKDFPGLIEMIVDTTISLDEKVCRELKDFNPDC
                     IVSDSLSFWGKLFAQKLNIPYVCSTTTFAFNKHTAKLMKQNFIEIIRMIFGVRRINKK
                     IKLLQRKGYEVKNFISIVSNDNDTDTIVYTSKEFQPMVETFSSKYSFVGPSVSKLIIE
                     PKERKRKLIYISLGTINNKNVSFYKNCINAFKDSDVDVIMSVGRSTDIKSLGNIPNNF
                     EVKNSVEQIAILQKTDVFVTHSGMNSVNESLYYGVPMVLFPQHSEQRMVAKRVVHLGA
                     GIMLKEDKSESIKKAVFQVINDNEYKENATKLSKSFYNAGGSKKAADVILQIICNSRQ
                     VDI"
     gene            complement(1925..2350)
                     /locus_tag="KNP36_001651"
     CDS             complement(1925..2350)
                     /locus_tag="KNP36_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873529.1"
                     /translation="MINENLKSLRKINQYTQEELAEKLNVSRQSIAKWESGESIPDIG
                     SCIKLAKLYNVKLDDLVNHSEEKTGIIVPPKGKFFFGAVVVGERGQIVIPKEAREVFN
                     INAGDKLLVLGDEERGLGIVHQRDLINFIGHVGVVHKEE"
     gene            2828..3577
                     /locus_tag="KNP36_001652"
     CDS             2828..3577
                     /locus_tag="KNP36_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440038.1"
                     /note="N-terminal region resembles flavodoxins. C-terminal
                     ferrodoxin region binds two 4Fe-4S clusters; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EFR1 family ferrodoxin"
                     /protein_id="HBF0873530.1"
                     /translation="MILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDELIST
                     DKPFIFVCPTYAWRLPIVVTDFIKETKFLGSNRVYFVMTCGGDTAKSINYIQKLCKYK
                     EWQLKGMAEIKMPENYIALFSTTDKETSKQMIKEADKQIYRIISDIRNENEFEIITPS
                     GLGGTIKSGIINTVFYKTIISAKGFHYTDKCIGCGKCVELCPLNNINLKNKKPVWKNN
                     CTHCMACICGCPTEAIEYKNKTQNRERYYLE"
     gene            complement(3753..4118)
                     /locus_tag="KNP36_001653"
     CDS             complement(3753..4118)
                     /locus_tag="KNP36_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBF0873531.1"
                     /translation="MEKECQQRMQEITSKFKECRKAISAMGDETRQLILIALLESDFN
                     GIRVGEITKKTHLSRPAVSHHLKILKEAEIVNLRREGTKNYYYLDSKKSQWRSLTELI
                     NLIFVGIQHISENDIRKGD"
     gene            complement(4134..4910)
                     /locus_tag="KNP36_001654"
     CDS             complement(4134..4910)
                     /locus_tag="KNP36_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0873532.1"
                     /translation="MKYQHIIEVDKELCIGCGLCKNDCPVNNIIIENKKSVIKKQDCL
                     MCGHCAAICPTKAITLTGFDEPPIELTNKPKLDSDELLMAIKSRRSIRKFKDKEVSSE
                     IIKQIIEAGRYTPSAKNSQDVSYIVLDNKKSIYENEAVKFFRKIKPIANIAIKYSKEV
                     EIDDNFFFKHAPIAIMIITKDKISGSLAASNMALMAESYGLGVLFSGYFSDVANNSPK
                     LKKLLGLKRSNHVLTTLVIGYPDVKYRRTAQKEVATVRYL"
     gene            complement(5321..6748)
                     /gene="ascB"
                     /locus_tag="KNP36_001655"
     CDS             complement(5321..6748)
                     /gene="ascB"
                     /locus_tag="KNP36_001655"
                     /EC_number="3.2.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HBF0873533.1"
                     /translation="MSFKNDFLWGGATAANQCEGGYNEDERGLANVDVCPTGKDRTAV
                     ITGKLKMFDFDDEHYYPAKTGIDMYHNYKEDIKLFAEMGFKVYRMSIAWSRIFPKGDE
                     ETPNEKGLQFYENIFKECKKYKIEPLVTITHFDCPMHLVKKYGAWRNRKMIGFYEKLC
                     NVIFRRYKGLVKYWLTFNEINMILHAPFMGAGICFEEGEDVEKIKYQAAHHELVASAI
                     ATKIAHEVDSNNLIGCMFAAGSVYPYSCNPNDVWEATKLDRENYFFVDVQSKGKYPNY
                     ALKYMEQKGITPEMEPGDIELLNKYTVDFISFSYYNSRCVRTDENADDMAEGNIFTSA
                     KNPYLSYSQWGWPIDPLGLRITLNHVYDRYEKPLFVVENGLGAKDIADENGYVEDDYR
                     IDYIREHIKAMHDAVSIDGVDLLGYTTWAPIDLVSAGTGEMEKRYGFIYVDRDNSGNG
                     SLRRMKKKSFEWYKKVIASNGEDLY"
     gene            complement(6809..8737)
                     /locus_tag="KNP36_001656"
     CDS             complement(6809..8737)
                     /locus_tag="KNP36_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0873534.1"
                     /translation="MGKYKQLAQEIVNNVGGKENISGLVHCITRLRFTLKDESIANDN
                     VLKNMEGIVTVMKSGGQYQVVIGNHVEAVYKDVVEIIGLDDSSTSSETKKSGNILDKG
                     IDIISGIFQPVLGIMAACGMLKGFNALFVAMGLYSDVSGGYMVINAAGDALFTFLPLF
                     LGYTSAKKFGLKPMLGLALGAAVCYPAIQGSSISAGADVMYTLFKGTMFASPVYIDFF
                     GLPIVSIDYTGTVVPIIFIVYFASRCEKLFNKCVPNLVKFFFVPMLTLLITVPVALIV
                     IGPIATFGSTLISQIVISIRDFSPLLAGAIVGFTWQILVIFGMHWGFIPVYINNVMTL
                     GYDNVMMPFFACTFASSAVVLAIFFKTKDKKLKEMAIPNFISGIFGVTEPAIYGILLP
                     LKKPFIISCIASGIGGAFYGFFNLRKFITGGMGIFELPAMIEPDGGMGNLIVALSGIA
                     ISMVVAFVLTMILYKDEKVEESKKVRNKGKEEIKEVKSTKLEREIVTSPIKGEVLKLS
                     DIEDAAFASGVLGQGVAIIPSDGKVVAPVDGVVTTLFPSLHAIGILSDTGVEVLIHIG
                     LNTIQLEGRGFEACIKQGDRITKGQTILNFDVDAIKELGYSTVTPIVITNSSQFLDVV
                     ETESKNIELEDNLITVLF"
     gene            complement(8882..9724)
                     /locus_tag="KNP36_001657"
     CDS             complement(8882..9724)
                     /locus_tag="KNP36_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0873535.1"
                     /translation="MIINKILNNNVVITLDDNDEEVIVMGKGIGYQKSKGNLIDKTKV
                     NKVFRISNKEISNKLQELLNNIPIEHMKLSSEIIEYAQIKLNKKLNESIYISLSDHTY
                     SAIQRMKEGINVKNAILWEIKRFYKEEFEIGMKALDIIENKTGIKLPEDEAGFIAFHI
                     VNAQLSEGHTLASDITKLIQEVLSIVRYHFRIEFHEESVFYYRFIMHLKFFAQRLLLD
                     SAHEGETDKELLSIIKSKYNKEFECVVKIKNFIKKQYNYILTDDELIYLTIHLAKVVK
                     DSNM"
     gene            complement(10071..11441)
                     /locus_tag="KNP36_001658"
     CDS             complement(10071..11441)
                     /locus_tag="KNP36_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0873536.1"
                     /translation="MKNKYEDVAQLIIDGLGGKDNIIDLTHCMTRLRFILKDEKKVNA
                     DKLKSIDKVVGVNSTSTQYQVIIGNEVGVVFNAIINKGINTTGDIKSDIKNKNKKNSI
                     LNNIIDTITGCMTPMIPALTASGMIKVILSLCTTFNWLSSNSSTYRVLDIIGDVAFYF
                     MPIILAINAAKKFNVNTSIAVIVVGVFLHPNFSAWVSSGDPISFIGVPIQGVIYAASV
                     IPALLTVWMMSYIENFIDKLTPSMLKTILNPTLVLLISAPIALIVIGPIGNFLGEGLA
                     SIINLLQGRLGFIMVCLLAAAMPFIVMTGMHHALTPIFISAFATTGQESLILISQVCA
                     NLAQGGATLAVALRSKDSKMKQLASAAWISAIMGITEPALYGVTLKLKKPAMLASIGA
                     GIAGLFAGITHVTLYVPQNSIMAVLGLSGEKGISNIVNGLIVIFIALVAPFIMTYVFG
                     VEKNVK"
     gene            complement(11480..12151)
                     /gene="pgmB"
                     /locus_tag="KNP36_001659"
     CDS             complement(11480..12151)
                     /gene="pgmB"
                     /locus_tag="KNP36_001659"
                     /EC_number="5.4.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-phosphoglucomutase"
                     /protein_id="HBF0873537.1"
                     /translation="MKAVLFDLDGVITDTAKYHFEAWHEIAKSLDIEIDETFNEKLKG
                     INREESLDKILLSANKVDSYTKEEKLKVCEEKNNIYIKLINSLTYKDILPGINELIKE
                     LKKNNVKLGIASASKNAPRILESLGVKDEFDCIVNPSLLKRGKPYPDIFIEGSKMLNL
                     KQYDCVGIEDSYSGIKAINAANMTSIGVGKKEVLGKCDHIVEDTSLLNYNTLLQAWSK
                     KINLD"
     gene            complement(12153..14543)
                     /locus_tag="KNP36_001660"
     CDS             complement(12153..14543)
                     /locus_tag="KNP36_001660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="HBF0873538.1"
                     /translation="MSLIFTTKDQLVELGFSKDTIKSNETLFTLANGHLGVRGNIEES
                     DFNNEYVDNMGTYVNGFYEESPITYGESAYGYAKQNQTICKLPNAHIVNFSIEGDCFD
                     LSKGITSEHTRILDLNEGILKRSFIWENSRGRKVKVSIERLVSQDIEELMMISYTITP
                     LNFNGKIKFKNKMENSMEKFNCEKVDDPRVASINKKQFKINVKKYNNKYFMNLVTERS
                     RLGLWCGFDSYITCGNITNETYNVSDECIEREIEVYAKKDERLNLEIVVGYSRVYSDL
                     NLNEERLKSLECLESLKCLESEAHLKSLELVLREACNIGFDKVKNIQRKKMNEFWTTS
                     DVEIEGDKTLQLGIKTNLFHIYQSAGRDGKTNISAKGLTGDGYEGHYFWDTEMYILPF
                     FIYTQPSIARALLDYRYSILDASRERARELGINKGCLYSWRTINGNECSAYYPAGTAQ
                     FHINADIAYGVRTYFEATNDEEFMMQNGLEILIETSRFWVEFGDYIESKNNKFCINGV
                     TGPDEYTAIVNNNYYTNLMAKYNLIYAVQMVDKFKHNLFSNEVFRKVKLQEYEVKNWI
                     NAAQNMYLPYDEEKKISKQDDSFLEKSVWDFKNTPKEKYPLLLHYHPLTIYRYQVNKQ
                     ADTVLSALLFPDEFSLEQKKRDFEYYEKITTHDSSLSRSIFGMMASEIGNHEKAYNYF
                     MDTALMDINNLQKNTSDGIHAANMGGTWMSLVYGFAGMKIKNDKLSFEPRIPKHWKNI
                     KFNILFRDNLVFVNIEEYKSYYKLIKGRNITILHDNKEIKLSKNIIEVNNCFKGSN"
     gene            complement(14569..16017)
                     /locus_tag="KNP36_001661"
     CDS             complement(14569..16017)
                     /locus_tag="KNP36_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBF0873539.1"
                     /translation="MKLGKDFLWGGAISANQSEGFYLDGGKGLSQFDKLPLNDKRLKN
                     VCLDEDNILNENNQYYPSHIGIKFCENYKEDIAMLAEIGFKCFRFSISWSRIFPTGEE
                     SEPNEKGLQLYDNIIKELKKYNIEPLITISHFDIPYSLVEKYSGWADRRVVNLYVKYA
                     EILMKRYKDDVKYWIPFNEMNMIMHIPYIGAGLTFIADENQLQKKYQAAHHQLLANAK
                     TIEIGRYINKEFKFGCMLAAGKTYPYTCKPEDVFATLEHERHNLFFSDVQVRGVYPSF
                     MSYYLKSNQIKLIIKEEDLSTLKDNTVDFVSFSYYSSACSSARAEGLEKSKANGPETI
                     KNPYLPKSNSVWQNDPVGLRITMNQLYERYQLPLFIVENGLGTQDIVNEDGKIIDDYR
                     IDYMKEHIKNMILGVNEDGIELIGYLMWGCIDVTSVSEGKMTKRYGIIHVDSDDYGRG
                     SFKRTKKQSAFWYKKVIETDGEILFNDMETHA"
     gene            complement(16422..17309)
                     /locus_tag="KNP36_001662"
     CDS             complement(16422..17309)
                     /locus_tag="KNP36_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0873540.1"
                     /translation="MAIYLEMPKLIHEFPFRTLSNEGEVLTTPHWHKEIEILLITEGV
                     VNLFINDKPMQLKKGEIVIIKGGDIHYILPSPGSERLVFQFDISFFNDLILLNEEKES
                     LINLFSSIKKCSRDWSAKIRKSVFDILIDIYNEDLYKIEGYSYAIKGKMYNLIPILYR
                     QIPREIEENTVEYEINSKEILERLNNIFKYVEKNYKQPIKLEDVSYEVGFSVYYFTKF
                     FKKNTGKTFITFLNEYRLEKAKWILLNNNISIVDLVEEVGFGSTKTFYRVFKEKIGVS
                     PLEFKKRYNSLEKKGSVSK"
     gene            complement(17409..17858)
                     /locus_tag="KNP36_001663"
     CDS             complement(17409..17858)
                     /locus_tag="KNP36_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0873541.1"
                     /translation="MEIREILTEESIILDLKSTTKEGIIQELVDKLYDTGSITLKSKF
                     IKALKHREKIGSTSIGYQMAMPHGKTKYVKKASIVIGKSKKGVDWPSIDGLPVKVIIM
                     FAMPQSGGNEDMILISKIAYILGGKNIGERLLNAHTKKEILDIFYEV"
     gene            complement(17848..19755)
                     /locus_tag="KNP36_001664"
     CDS             complement(17848..19755)
                     /locus_tag="KNP36_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0873542.1"
                     /translation="MLVSRQIEFLKLILNENKYRPIKYFKDKLNVSDKTLQKDLKMIE
                     KYLETFNIKIDIKRGYGILIEDLAKKNIDLINSLNIQSKENKSLSVEQRRMEILKYLL
                     LNSNNITSINQLADKYYVSKTSIVNDFKYIEAWIKEYNLKLNKTLEGTKIIGKEVDIR
                     KSIAKMMDDLLDENYEQHDISELTRLDSATFSALINLFDIDSIIFVETIITELEYNLG
                     YTINQPYYINLITHILICLKRIEEGNQIESQEEREISVDNLDELVYKNVTTLIDKIEN
                     RYRVKITKDEIMYIYIFLVSSGFSSENNSSYNDESDRLSESEKVSSIMIENMSRFLNI
                     NLKNDDLLQKSLASHVRPMLNRLRYDIQIKNPLLGEIQERFSDVLGLCMMTINIMTEY
                     DNLKNISIDEVSYLATYFQAAIERNMSSKRVIVVCHTGYGTSQLLAARLKREFPEWTI
                     VDIVPMHQLSKRNLDDVDFVISTVNLDLKDKLHIVVSVLLMESDINNIKNALLSKPKK
                     SMNLDTNLLGMYLEDNIYFNFDVAQMESLIGVNLGSKYESISLGKDLNIYIHKQSKLN
                     KGIMNINNVTRTIDIYLEISNQSFLKNILMEISNLYRQKNYINYIIDCKSKEDIKILF
                     KNNLLEKTNGN"
     gene            complement(20023..21918)
                     /locus_tag="KNP36_001665"
     CDS             complement(20023..21918)
                     /locus_tag="KNP36_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0873543.1"
                     /translation="MIGKILRSDCIVLDKQLQTKKDVINYMANHLYHGNYINNKEKFI
                     ADINKREKESSTNMGNLIAIPHAKSNVVNQPVMMYLRTDREITDNDGQKLRSFFMIAV
                     PESGSDEHLKIISKLATYLMEENFLKHLLSAETPYEILSIFNNKAAESGDFSNNQNKG
                     LIVGITGCPTGIAHTFMAKKALEEAGQELGYEVKIETHGAIGVENKLTKEDIKRAEYV
                     IIACDKEVQLSRFIGKKVLQKKVVDAKNVSLAKNLIINAENGMAKEIKPGGKTLEDSK
                     EMLQGSEKKGVYKHLMSGVSEMIPFVVIGGIGIAIAFMFGIFASDPTHETYNPIAGFF
                     GQLGGDSAFKLFIPILAGFIAKSIAGRQGFAPAMIAGFMAVIGGSGFIGGMVAGFATG
                     YIALGVMKITENLPDVLKGVNAVLICPLLIAFTSGAIMFFVVNTPASWLNEALQSWLQ
                     SMSGTNKVLLGAILAGMMASDMGGPINKTASAFGLAMFSSNIFEPSAALMVGGMVPPL
                     AISLAMLIFKNKFTKEERKSSLPTAIMGASFITEGAIPFAAADPLRMIPANIIGSCIG
                     GAICMSLDITLMAPHGGIFVIPFACSAPVAYIACILIGTVITALIIGVTKPTIRSENS
                     EVELLGA"
     gene            complement(21954..22832)
                     /locus_tag="KNP36_001666"
     CDS             complement(21954..22832)
                     /locus_tag="KNP36_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketose-bisphosphate aldolase"
                     /protein_id="HBF0873544.1"
                     /translation="MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPV
                     ILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGENKEQILRAIRCGFTSVMID
                     GSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKD
                     FVEKTGVDTLAIAIGTAHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEI
                     AQAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMN
                     LFNAIDKLKCFYKNKN"
     gene            complement(23375..23545)
                     /locus_tag="KNP36_001667"
     CDS             complement(23375..23545)
                     /locus_tag="KNP36_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873545.1"
                     /translation="MSALLYGVCNKSISVSIVINMQEFKIGVSMAYGVLVIGICYIAL
                     GIIFKLDRKRFT"
     gene            complement(23942..24154)
                     /locus_tag="KNP36_001668"
     CDS             complement(23942..24154)
                     /locus_tag="KNP36_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873546.1"
                     /translation="MAILMKTKIKEYREKLLMTQNELAKLVGVRRETIVHLENGKYNP
                     SLKLAMDIAKVFDTTVENLFEFIEEE"
     gene            complement(24155..24571)
                     /locus_tag="KNP36_001669"
     CDS             complement(24155..24571)
                     /locus_tag="KNP36_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873547.1"
                     /translation="MSKSETGVRSKLILELLVITYFFIAVLATKYIFKGPSTASLPGL
                     SWLIVFGCYSIYNKKYNDLVDESSEFILSKVNKIAIKIMIYSIVIISIFFATPYTSNI
                     NISNLDTGIILIAVLFIQSLSKLVLYIYFDKRGICN"
     gene            complement(24639..25052)
                     /locus_tag="KNP36_001670"
     CDS             complement(24639..25052)
                     /locus_tag="KNP36_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873548.1"
                     /translation="MSKSELGVKTNLVSELLMISYFFIDSLLKKFIFKEGNLCITFII
                     LFAFWACDFMYNKKYNDLVDEASKLMLLKVDHIASKIMLYSILLIAVFFSANYTRGLD
                     ISNLDIGVILLAILFIQSLSKLILYIHFDRKGICN"
     gene            complement(25885..26514)
                     /locus_tag="KNP36_001671"
     CDS             complement(25885..26514)
                     /locus_tag="KNP36_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine amidotransferase"
                     /protein_id="HBF0873549.1"
                     /translation="MKNRKVYMYVFDTMSDWEVAYLTAELNTGRYFKKGLKPLKVITV
                     GIDKNPIITMGGLKVLPEITVDEFNMESKDLLILPGGNTWLSMNHEIILEKVKEALRQ
                     DSIVAAICGATLGLAKKGLLDFRNHTSNDLEFLKMVIPNYSGEKYYKTESVVSDENLV
                     TASGIAPLEFTFQVLKLLDVFESEALNSWLNLYKTHDSKYFFELMNCNK"
     gene            complement(26593..27555)
                     /locus_tag="KNP36_001672"
     CDS             complement(26593..27555)
                     /locus_tag="KNP36_001672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017561613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBF0873550.1"
                     /translation="MAKIDNMMSILWMLNSDKKITAKQIAEKLEINIRTVYRYIDVLS
                     ASGVPIISDTGHNGGYSLLNNFTKAPLFFDIEEQKSLLHAALFAKKEGYFLDEALDKS
                     ILKLKMYSNQKQEDILTNHLRALEVIKPIGKVSIESVLKKLENSILKELSVEINYHAG
                     RKVKSKYRIINPYGIVHWNNNWYVVAFCNMRNEVRSFRVDRISEIIETSNTFNRPTEF
                     SASEFFIKGIIPEIKDEQNIIQLVIEGSIDSLDSLSQHWFLGHYLKERTPNKIIFMLE
                     EEVICKYIPNILLPYRKTIQVIEPLSLRKKIIEDLLELIDYYQI"
     gene            complement(28317..31832)
                     /gene="cbpA"
                     /locus_tag="KNP36_001673"
     CDS             complement(28317..31832)
                     /gene="cbpA"
                     /locus_tag="KNP36_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-binding adhesin CbpA"
                     /protein_id="HBF0873551.1"
                     /translation="MQQKCKKKALSMILSISMGLGPVASFNASNTFADTIEESTNAGN
                     AEGGTNAGNAEGDTNAGDAEGDTNAGDAEGDTNAGDAEGDTNAGNAEGDTNAGDAEGD
                     TNAGNAEGDTNAGDAEGDTNAGDAEGDANAVVVEEEATAEEPTSVGDFKISGGEINVD
                     FKFASGVLTILSGKQMTIQNNNPNTPTTHRIVIPKDVKAELIFDGVNIKTASNSPFTL
                     TPDKDGGAYAHVILQDGSENKLESGDVYYPGMRAGKGTTLIIDDSVVNRDIEGEFIVP
                     EGGKIPRDVTLENGDKLKKGDRLTLLDSNNRGSLKVVGNYYSAGIGGGNTESGGNIII
                     NGGAITAIGQESSRNTGYGAGIGGGGNGSGGDITINGGIITAKGAYHGAGIGGGYYTT
                     TKNALSPSVVDPSTGSGYSGNITINGGLSYSYGGAHGSAFGDGCVNPGTNRGYRILVT
                     GGTILPYMTGVGDWIFDLSATTGDVIVTGGSLKATTFKSLGGAVAYGDLEKKTKVFMN
                     KISLTYLGQDKVSTTLVDDFKMLIDGKIYPYGAPSYTDAQGILYLWFSDQFKGSEVSV
                     NLVVIDKITGEVLKPDDFYIKDIGSGSQFLKQYEEFTIDDTPPYLIIKRYDGLPFEED
                     VEKSFLDWIFKDGGIPIITPKGEKLTDKKFMTISSQRLNEETMEPDINLGSDDLTKQV
                     DAGKYQLSITSTQFSSIYPFKDAYWGHRAYYKAEIIPADTETSLVVEESKAKTDVFKP
                     TDTFTLNVTISPDKKEGPDCASPRGYVQFYINGKEYKDPVELKTHNKGSESHNYSTAS
                     IEWRPLDSNHHIFTTEQTITVKYIGDDINYIEGSEDEKKLKLDMTNVDVDGDGIPDIN
                     IDTDGDGRPDINIDTSGDWKPDINIDTDNTGEWKPSTEGGNGDGIWKPDKNIDTNGDG
                     NPDTDYNRPAIDTDNDGVDDYWKPDKNVDTGSGGYDTGNPNLNKPDPDNGGNSKPDSG
                     NGGNSKPDSGNGGNSKPDSGNGGNSKPDPDNGGNSKPDPDNGGNGKPDPDNGGNSKPD
                     PDNGGNSKPDPDNGGNSKPDIDTDGDGKPNINIDTDGDGKPDINIDTDGDGKPDINID
                     TDGDGKPDINIDIDGDGKPDINIDTDGNGKPDINIDTDESLDSNVGQNVQTGDQSNIM
                     LDLALMFISLFFLIKNLTNKYLRRK"
     gene            32101..32673
                     /locus_tag="KNP36_001674"
     CDS             32101..32673
                     /locus_tag="KNP36_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class B sortase"
                     /protein_id="HBF0873552.1"
                     /translation="MKKLVKILINIICIITLIFSSLSIYIKLSEYKKADEVYTELREN
                     TINNSKHQELYDKNNDYRFWLKINNVNIDYPVVQGYNNDFYLTHDFYKNYLPLGSIFM
                     DYRNNFENDKSLIVYGHYMKNKTMFGQLENYTDEAFFKENNLVEINYKVQTYTYEIFS
                     VYTADLINRDYLSIHFNSNYEFKDYLNYIT"
     gene            complement(33686..34348)
                     /locus_tag="KNP36_001675"
     CDS             complement(33686..34348)
                     /locus_tag="KNP36_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873553.1"
                     /translation="MKMLKVIDIKKIYGKGENEIKAVDGITLEIEPHKFSAIIGQSGS
                     GKSTLLHCMAGLDKPTLGNVFMDNLDLYTLSDEKLSNLRSKEFGFIFQNYNLIPVINV
                     YDNIVLPILIAKGKIDNNYINDLITKLGLESQINKFPNELSGGQQQRVAIARSLANKP
                     SIIFADEPTGNLDSKTTNEVMNLLKYCVNEYKQTLVMITHNDEIAKMADCIITISDGK
                     VI"
     gene            complement(34365..36920)
                     /locus_tag="KNP36_001676"
     CDS             complement(34365..36920)
                     /locus_tag="KNP36_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0873554.1"
                     /translation="MGIYLKMSLAYLKKNKLRTLLLIIGVMLGVMLIFGPSVIKDSQN
                     ENNVVAIHELYSGYHVEFSDLTLDDAKKLETDEKVSKGNSVQNLGRISDKKGNSFILT
                     SSNEEYLKSRYNKIIEGRLPKNNNEIVLEKKALEAMNLSEGVGSTLNLTIKKNYKDTN
                     GSNQLFSINKEFKIVGVMEKPKGYYDVVWQYEAVTYGNDETNNIIPHDAISYNSILSF
                     KSGWRNIEGECDYLMKKYKLGQKSFLPNVPLVRELRYVEDDKNDPNVFKRNVLITTVS
                     IIFIFNIFNITLNQSVKEMGLLRLMGAKKRNIRCMIIYQALIITIIGILLGLVAGVTY
                     SYIGISNYNEVLYSEAGLNPKLYINNEIVIKAILVGMISVFISCIIPTFKIGKISPIE
                     SIINTDKIKNHRSRLGIDRLVSKIFGFYGFMGLKNIGRNKVRAAISMLSIALGGYIFI
                     TTFSSMQEEVNSKIEDMQNRYNITMQFGVNADPQISKYTDSDVENIEKIKGVKSIHKI
                     QITNGMFTFNNKDINKEFTTYNGVEKKEIMEDKLVLKLYDDDYIDEKLNDFVEEGSLD
                     DIKKDTDGYPNVAVYNYFYDIVDDHTIKPIFKELNIGDIITVKIPVEENNTIVYKEMK
                     VRVAVILKDEWIAMGDGDFMPDLEIITSNIHSKNITGEQKYTQLGINLENPYDEIVNN
                     EIQKISRSIPGSLFNSRLSYHEMSESIYKSYIKSQIAIIALVLIIASINIFCTIRTNL
                     LIRKKEISTLRALGVSLKNMKKMLIYEALAYAVFSFIIAMIPSFINLVKFTNWNNDAY
                     INYGIENFMSFTFPIKESLLFFAISVFVCLISVVVSNRDFESMNIIEGIKENE"
     gene            complement(37160..37348)
                     /locus_tag="KNP36_001677"
     CDS             complement(37160..37348)
                     /locus_tag="KNP36_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="HBF0873555.1"
                     /translation="MRKYKAILLTLIISIIAIIGFIIYNNYFRKWNEAEKYIDKYMTY
                     QGVSGDDIERITKEKYTK"
     gene            complement(37360..37539)
                     /locus_tag="KNP36_001678"
     CDS             complement(37360..37539)
                     /locus_tag="KNP36_001678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873556.1"
                     /translation="MIHIEISEKEFFRKIEEVFDKGEVNVEVDNLGDIKIQVKKFDDK
                     TKSLELKLIKEFKLK"
     gene            complement(37544..37801)
                     /locus_tag="KNP36_001679"
     CDS             complement(37544..37801)
                     /locus_tag="KNP36_001679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873557.1"
                     /translation="MSKKISESIENSGLRVAENKSDGSFVLSLGNLEYTKEQPSQVLH
                     YSITKEKKDTKEILSIQCVKDFSYNEKLSEDDKFIMAIYNI"
BASE COUNT        12378 a         6613 c         3972 g        15184 t
ORIGIN      
        1 acactagtaa gatatactaa tatataaata cttaaattta gttttattta aacgctctag
       61 tgatattttt aaataaattt taataaaaat tattctattt tgtcataaat catttatctg
      121 gcttatattt aagatatatt ggtggatact ttacactttt taattcctca ttacttctta
      181 aaagtttatt attattttcc atatcataaa tttgtaacat tactttattt acatatagag
      241 cataataatt atcactataa aaatattgat actcatatcg agggtcatct ttgtaataca
      301 ctttgtatag tattccttcg taacttgcct tcttggcttt ttcttttgta atacttttta
      361 tattatcttt tgaaatatct tgttttacca tatacttatc aatatatgtt tcagcatctt
      421 tccatggttt aatgcagttt ttatatacaa caaaccctgt tacacttata atacctataa
      481 ttaatactat aaaaataact ttatattttt tcatattaat cctccttcat ttattattta
      541 aaactcgata taatgcacta aaaaaaggat gttatctttt ttattaaaat ataacatccc
      601 tcatatttag catcaatata tatgccccaa ctggtaggtt aaaagacccc actgtcagta
      661 ctttgattaa attacatgta tgtatatata tttttaacaa atctattata tgtcaacttg
      721 tctactatta catataatct gtaatattac atctgctgct ttttttgagc ctcctgcatt
      781 ataaaagctt tttgatagtt tagttgcatt ttctttatat tcattgtcat ttataacttg
      841 aaatactgct tttttaatac tttctgattt atcctctttt aacataattc ctgctcccaa
      901 atgaacaact ctcttagcta ccattctctg ctccgaatgt tgaggaaata ataccatagg
      961 tactccataa tataaacttt cattaacact attcatccca gaatgagtaa caaacacatc
     1021 agttttttga agtatagcaa tctgttcaac actattttta acctcaaaat tatttggtat
     1081 atttcctaaa cttttaatat cagtacttct accaacagac ataatcacat caacatcaga
     1141 atctttaaat gcatttatac agtttttata aaagctaaca tttttattat taattgtacc
     1201 aagcgaaata tatattagct ttctttttct ctctttaggt tcaataatca actttgatac
     1261 tgatggacct acaaatgaat acttactaga gaaggtttct accattggtt gaaattcttt
     1321 tgatgtatat acaatggtat ccgtatcatt atcattagaa actatagaaa taaaattttt
     1381 tacttcatac ccttttcttt gtaaaagctt tattttttta ttaatgcgtc ttacaccaaa
     1441 aatcatacgt ataatttcta taaagttttg tttcatcaac tttgctgtat gtttattaaa
     1501 tgcaaaagtt gttgtagagc atacatatgg aatattaagt ttttgtgcaa ataactttcc
     1561 ccaaaaactt aatgaatctg atacaatgca atctggatta aaatctttaa gttctctaca
     1621 aactttttca tctaaagaaa tagtagtatc tactatcatc tcaattaatc caggaaaatc
     1681 cttaccaatt tttttctcat ctccagggag taattctgga aggtatttat cacaacaaat
     1741 aaattttgct ccagcacctt caattttatc tttaaattca ttaaaagaat aatacaatac
     1801 ctcatttcct ctatccacta attcacgaac tacttcaata gtaggattag tatgaccata
     1861 tgcaggaatg ctaaaaaata ctattttact catatttcat acctcctttt ataatttttt
     1921 taaatcattc ttctttatgt actactccca catgacctat aaaatttatc aaatcacgtt
     1981 gatgaacaat tcctaatcct ctttcctcat ctccaagtac caataattta tctcctgcat
     2041 ttatattaaa tacttctctt gcttcttttg gaatgacaat ctgaccacgt tcaccaacta
     2101 caactgctcc aaagaaaaac tttcctttag gaggtactat aatacctgtt ttttcttccg
     2161 aatgattaac taagtcatct agtttaacat tgtacaattt tgcaagttta atgcaactac
     2221 ctatatcagg aatagattct ccactttccc attttgctat tgattgtcta gaaacattaa
     2281 gtttttcagc taattcttct tgtgtatact gattgatttt tcttagactt tttaaattct
     2341 cattaatcat atttttcata cctcctatgt ttataatatt ggatttatta tttaaattct
     2401 atcaactaat cttaacattc atatatatat ttatatactt ttattatata aatttattgt
     2461 tcaggtaaca tatttcctta agttatcgta aacaaaaaaa caaacacaaa tctactaact
     2521 gttgttaaag tatttaagtt aaggtcattt acattatcaa atatttctac accttcaaaa
     2581 taacctttat atttataatc tttcataagc aaattattat cccttctcat atacaagtcc
     2641 agttgatgtc ttgttgctaa atttaatggt aatcaaattc tttaccaata agtataaaaa
     2701 ttactaatgt gttataattt tcttaactac taaattttac atacatttga atagaatata
     2761 tcaataaatt actataataa ataaaaaatt aagagttaaa ataaaaaata gttagggaga
     2821 tattattatg attttatatt ttagcggaac tggtaatagc cgatatgtgg ctcgtaaaat
     2881 tgcacaagaa ttaaatgatg aactgatatc actaaatcaa cttataaaag aggaaaaaac
     2941 agatgaatta atatcaacag ataaaccatt catatttgta tgtcctactt atgcatggag
     3001 attgccaata gtggttacgg attttataaa agaaacaaaa tttctaggaa gcaacagagt
     3061 ttactttgta atgacttgtg gtggagatac agcaaaatcc ataaactata ttcaaaaact
     3121 atgtaaatac aaggaatggc aattaaaagg tatggcagaa attaaaatgc cagagaatta
     3181 tatagcttta ttttctacaa cagacaaaga aacatcaaaa caaatgatta aagaagcaga
     3241 taaacaaata tataggatta tttctgatat acgaaatgaa aatgaatttg aaattattac
     3301 tcctagtggc ttaggaggta caattaaaag tggtataata aatacagttt tttataagac
     3361 aattattagt gccaaaggat ttcattatac tgataaatgc attggctgtg gaaaatgtgt
     3421 agagctatgt cctttaaata atattaattt aaaaaacaaa aaaccagttt ggaaaaataa
     3481 ctgtactcat tgtatggcat gtatttgtgg ttgccccact gaagctattg agtataaaaa
     3541 taaaactcaa aacagagaaa gatactattt agaataatat attcttaata tttaaaccat
     3601 tataaaatga actataccca ttgttttata cagttttaca tattttaact gtctcctaag
     3661 atgggtatag ttcaaaagat agtgtctcaa agtgaacttt ttagttcttt ttagttccta
     3721 aatcaatctt tttgtattaa atcaagtata atttaatcac cttttcttat atcattttca
     3781 ctaatatgtt gtattccaac aaatataaga tttattagct ctgttagtga cctccattgt
     3841 gatttttttg aatcaagata ataataattt tttgttcctt ctctacgcaa attaacaatc
     3901 tctgcttctt ttaatatctt aagatgatga gatacagcag gacgagaaag atgtgttttt
     3961 tttgtgattt ctcccactcg tataccatta aaatcactct ctaagagagc aattaaaatc
     4021 aattgtctag tctcatcacc catagcagag atagctttgc gacattcttt aaatttagac
     4081 gttatttctt gcattctttg ttgacattct ttttccataa aatccaccct ctcttataag
     4141 tatctaacag ttgctacttc tttctgtgca gtacgtctat atttaacatc tgggtatcca
     4201 attactaatg ttgtaagaac atgattactg cgttttagac ctaaaagctt ttttaatttt
     4261 ggcgaattat ttgctacatc tgaaaaatat ccactaaata aaacacctag gccataagac
     4321 tctgccatta atgccatatt tgatgctgca agtgaaccac taatcttatc ttttgtaatt
     4381 atcattattg caataggagc atgcttaaag aaaaagttat cgtcaatctc aacttctttt
     4441 gaatatttaa tagctatatt tgcaataggt tttatttttc taaaaaattt cactgcttcg
     4501 ttttcataaa ttgacttttt attgtctaaa acaatatatg atacatcttg tgaattttta
     4561 gcactagggg tatacctacc tgcctcaata atttgcttta taatttctga agaaacttct
     4621 ttgtctttaa atttacgtat acttcttcta gatttaattg ccattagtaa ttcatctgaa
     4681 tctagctttg gcttatttgt aagttctata ggaggttcat caaatcctgt caaggtaata
     4741 gcttttgtgg gacatattgc tgcacaatgt ccacacatta gacaatcttg ttttttaatt
     4801 actgactttt tattttctat aattatattg tttactggac aatcattttt acaaagccca
     4861 catccaatgc aaagttcttt gtcaacttct attatatgtt ggtatttcat attcattcat
     4921 ctacctttcg tttattagtt taaactatta taacacgtag acatttttta tattcattgg
     4981 taaagaattt gattaccatt aaatttttaa tttctctatt aaataaattt ttcatagaat
     5041 tttaaagtat catagtttat acataataaa aaagacaagc ttaaaaccta agcttgcctt
     5101 tttcatcttt tattacaaag taaattgcac ttacttccca tacttcttaa caattttatt
     5161 ttctaaaatt ttatttgtga atcatactat tgcataaata caatgtaaaa taattctgta
     5221 ttgattttct atagttaaaa aagttaaaaa ttatacttat tattaatttt tatactcttc
     5281 ttatttaata caaatttctt atttaacata gatttcttgt ctaatataaa tcttcaccat
     5341 ttgaagcaat tactttctta taccattcaa aacttttctt tttcattctt cttagacttc
     5401 cattaccact attgtctcta tctacatata taaatccata acgcttttcc atttcacctg
     5461 taccagcact tactaaatca ataggtgccc atgtagtata acctaataaa tcgaccccat
     5521 ctatagaaac tgcatcatgc atagctttta tatgttctct tatataatca attctgtaat
     5581 catcttctac ataaccattt tcatcagcta tatctttagc acctaatcca ttttctacaa
     5641 caaatagtgg cttttcatat ctatcatata catgatttag tgtaattctc aaacctaatg
     5701 ggtcaattgg ccatccccat tgactgtatg aaagatatgg atttttagca gatgtaaata
     5761 tgtttccttc agccatatca tctgcatttt catcggttct aacacaacgg ctattgtaat
     5821 atgaaaatga aataaaatct actgtatatt tattcaataa ttcaatatca ccaggttcca
     5881 tttctggtgt aatacctttt tgctccatat actttaacgc atagttagga tatttacctt
     5941 tagattgtac atccacaaag aagtaatttt ctctatctaa ctttgtagct tcccatacat
     6001 cattaggatt acaactataa ggatatacac ttccagctgc aaacatacat ccaattaagt
     6061 tatttgaatc aacttcatgt gctattttag ttgcaattgc actagctaca agctcatgat
     6121 gggcagcttg atattttatc ttttcaacat cttcaccttc ttcaaagcaa ataccagcac
     6181 ccataaatgg agcatgtaaa atcatattta tttcattgaa agttagccag tacttcacta
     6241 atcctttata tcttctaaag ataacattgc ataatttctc atagaaacct atcatttttc
     6301 gattacgcca tgcaccatac tttttaacta aatgcattgg acaatcaaag tgtgtaatag
     6361 tgactaaagg ctctatttta tattttttac actccttaaa tatattttca taaaattgaa
     6421 gtcccttttc atttggtgtt tcttcatcac cttttggaaa tattcgactc catgcaatgc
     6481 tcattctata tactttaaat cccatttcag caaataactt tatatcttct ttataattat
     6541 gatacatatc aataccagtt ttagctggat aataatgctc atcatcaaaa tcaaacattt
     6601 ttagtttccc tgtaataact gctgttctat cttttcctgt tggacataca tctacatttg
     6661 ccaatcctct ttcgtcttca ttgtatccac cttcacattg attggccgca gtagctcctc
     6721 cccataaaaa atcattctta aaactcatag tcaaagcctc ctaaaattat aaccaaagca
     6781 ctagattatg ctaatacctc aatctttact aaaataagac tgtaattaga ttgtcttcta
     6841 attcaatatt tttactttct gtttctacta catctaaaaa ttgtgatgaa tttgtaataa
     6901 caattggagt tacagtacta taccccaact cttttattgc atcaacatca aagtttaata
     6961 tagtttgacc ttttgtaatt ctatcacctt gttttataca tgcctcaaaa cctcttccct
     7021 ctaattgaat agtatttaat ccaatatgaa taagcacttc aacacctgta tcagaaagaa
     7081 tccctatagc atgtagacta ggaaataagg ttgtaactac cccatctact ggagcaacta
     7141 cttttccatc actaggtatt attgccaccc cttgacctag tacaccagat gcaaatgctg
     7201 catcctctat atcacttaat tttaatactt caccttttat aggacttgtt actatttctc
     7261 tttctaattt agtagacttg acttctttta tttcttcttt acccttattt cttacttttt
     7321 tagactcttc tactttctca tctttatata aaatcatagt taatacaaaa gctacgacca
     7381 ttgatatagc tataccagaa agagctacta ttaagttacc cattccccca tctggttcaa
     7441 tcattgctgg aagttcaaat attcccattc ctccagttat aaattttcta agattaaaga
     7501 atccatagaa agcgcctcca ataccactag caatacaact tattataaat ggtttcttta
     7561 aaggcaataa tattccataa attgctggct ctgtaactcc aaatatacca gatataaagt
     7621 ttggtattgc catctctttt agttttttat ctttagtctt gaaaaatatt gccaacacaa
     7681 ctgccgaact tgcaaatgta caggcaaaga atggcatcat aacattatca tatcctaaag
     7741 tcataacatt gtttatatat acaggaataa atccccagtg cataccaaaa ataacaagaa
     7801 tttgccaagt aaatcctact atagcacctg ccaatagtgg actaaaatct cttattgaaa
     7861 ttacaatttg tgaaataagt gtagaaccaa atgttgctat agggcctata actataagtg
     7921 caacaggcac tgttattaat aatgtaagca ttggcacaaa gaaaaactta actaaatttg
     7981 gaacacactt attaaataat ttttcacacc tagaagcaaa atacactata aatataattg
     8041 gtacgactgt tccagtataa tcaattgata caattggtag tccaaagaaa tcaatatata
     8101 ctggtgatgc aaacattgtt cctttaaata aagtgtacat cacatctgct cctgctgata
     8161 tactgctacc ttgtatagca ggataacata ctgcagctcc tagtgctaat cccaacattg
     8221 gttttaatcc aaacttctta gctgaagtat atcctaagaa caaaggaagg aatgtaaata
     8281 atgcatctcc cgctgcattt attaccatat aaccaccaga tacatcacta tataatccca
     8341 ttgctacaaa taatgcatta aatcctttca acataccaca agctgccatt attcctaaca
     8401 ctggctgaaa aattcctgat attatatcta tacctttatc tagtatatta cctgattttt
     8461 tagtttctga acttgtactt gaatcatcta aaccaattat ttcaactaca tctttataga
     8521 cagcttcaac atgatttcct ataactactt gatattgtcc tccacttttc attacagtaa
     8581 caataccttc catgtttttt aatacattgt catttgctat actttcatct tttaaagtaa
     8641 aacgtaatct tgtaatacag tgtactaatc cactaatatt ttcttttcca ccaacattgt
     8701 ttactatctc ttgtgctaat tgtttgtatt ttcccatttt tctcctccat atttcgttta
     8761 aattaatttt ttgaaatttg aaggtttggc caactcaatg ttaccatcca accataagta
     8821 taattttgtt agtatcactc ctttcaatca ttcttaatat actgctgaaa aattatttca
     8881 cttacatatt tgagtcttta actactttag ctaaatgtat tgttaaatat ataagctcat
     8941 catctgttaa tatgtagtta tattgttttt taatgaaatt tttaatttta actacacatt
     9001 caaactcttt attatattta gatttaataa tgcttagtaa ttctttgtct gtctcacctt
     9061 catgtgcact atctaaaagc aatctttgcg caaaaaactt taaatgcatt ataaatctat
     9121 aataaaacac tgattcttca tgaaattcta tcctaaaatg atacctaact atgctaagta
     9181 cttcttgtat taacttcgta atatcagatg ccaaagtatg accttcactt aactgagcat
     9241 tcactatatg aaaggctata aatccagcct catcttctgg taattttata cctgttttgt
     9301 tttcaataat atctagtgct ttcattccaa tttcaaactc ttctttataa aatcttttaa
     9361 tttcccaaag gattgcattt tttacattta ttccttcttt cattctttga attgcagaat
     9421 atgtatggtc acttaaggat atgtaaatac tttcatttag cttcttgttt aactttattt
     9481 gtgcgtattc tataatttca cttgataatt tcatgtgttc tataggaata ttattgagta
     9541 attcttgtag tttgtttgat atttctttat ttgatattct aaatacttta tttactttag
     9601 ttttatctat tagattgcct tttgattttt gataaccaat tcctttaccc ataacgataa
     9661 cttcttcatc attatcatct aatgtgatta caacattatt gtttaatatc ttattaatta
     9721 tcatgattat cctcctttta agcataaaaa aagcttatcc ataataatgg gcatactcct
     9781 tcctaggata ctgctattat taatgaataa gcttagcttg tacttaaaca attactacct
     9841 aattccaatt aatatgataa aacatcagac atattttgtc aactttttat ttccatatac
     9901 ttcatcaatc ttttatgttg ctttttgtca gttataataa ttattcttat taatattaac
     9961 ttatttcttt gcatcaatat aaatacaaaa caagttatag tcaataataa taaaaattct
    10021 attaatgtaa atagttaata ttatacttcc tctactacat tatctgtact ttatttaaca
    10081 tttttttcaa ctccaaaaac atatgtcata ataaatggag caaccaatgc tataaatata
    10141 actataagtc catttactat atttgaaatc cccttttccc ctgataatcc aagtactgcc
    10201 attatactat tttgtggaac atataaagtc acatgagtaa ttcctgcaaa taaccctgcg
    10261 attcctgctc ctatagatgc taacatagca ggttttttaa gtttcaatgt aactccataa
    10321 agagctggtt cagttatacc cataatagct gatatccatg cagctgatgc taactgtttc
    10381 atcttactat ctttgcttct taatgctaca gctaatgttg cgccaccttg cgctaaatta
    10441 gcacaaactt gagatattaa tattagcgat tcttgtcctg tagttgcaaa tgctgatatg
    10501 aatataggag tcaatgcatg atgcatccct gtcataacga taaatggcat tgcagctgct
    10561 aataaacaaa ccattataaa tcctaacctt ccttgtagta aatttattat actagctaat
    10621 ccctctccta agaaatttcc tattggtcca attactatta atgctattgg cgcacttatt
    10681 aataatacta aagttggatt taaaattgtt tttaacatgc taggtgttaa tttatcaatg
    10741 aaattttcta tatatgacat catccatact gttaaaagtg cagggataac agatgctgca
    10801 tatataacac cttgaattgg tactcctata aatgatatag ggtccccact tgatacccat
    10861 gcagagaaat ttggatgtaa aaacacacct actactataa ctgctattga tgtattaaca
    10921 ttaaattttt tagctgcatt tattgcaagt attataggca taaagtaaaa tgctacatct
    10981 cctattatat ctaatactct atatgtactt gaatttgatg atagccaatt aaaagtggtg
    11041 caaagagata atataacttt tatcatccca gatgctgtaa gggctggtat cataggtgtc
    11101 atacaaccag ttattgtatc tattatatta tttaaaatac tatttttttt atttttattt
    11161 tttatatcgc ttttaatatc tcctgtggta tttatcccct tatttattat tgcattaaat
    11221 acaacaccta cctcattacc tattatgacc tgatattgag ttgaagttga gtttactcca
    11281 actaccttat ctatagattt taatttatct gcattgactt tcttttcatc ttttaagatg
    11341 aaccttaatc gtgtcataca atgagttaag tcaattatat tatcttttcc tccaagtcca
    11401 tcaattatca attgagctac atcttcatat ttattcttca taccttatcc tctcttttaa
    11461 aataattttt aatataattt taatccaaat taatcttttt actccaagct tgtaatagtg
    11521 tattgtaatt taataagcta gtatcttcta caatatggtc acattttcct agtacttctt
    11581 ttttccccac accaattgat gtcatattgg cagcatttat agctttaata cccgaataag
    11641 aatcttctat tcctacacaa tcatattgtt ttaaatttag catcttgctc ccttcaataa
    11701 aaatatcagg atatggtttt ccccttttta ataaagatgg atttactata caatcaaatt
    11761 catcttttac tcccaaagat tctaatatcc taggtgcatt cttactagca gatgctattc
    11821 ccaatttcac attatttttt ttaagttctt ttataagctc atttatccct ggtaatatat
    11881 ctttatatgt taatgagttt attaacttta tataaatgtt atttttttct tcacacacct
    11941 ttaacttttc ctctttagta taactatcta ctttattagc agataacaat attttatcta
    12001 atgattcttc cctgtttatg ccttttaatt tttcattaaa agtttcatct atttctatat
    12061 ctagcgattt tgctatctca tgccaagctt caaaatgata cttagcagta tctgttataa
    12121 ctccatcaag atcaaataag actgctttca tattaattac tccctttaaa acaattatta
    12181 acttctatta tgttctttga taattttatt tctttattat catgtaatat ggttatattt
    12241 ctacctttga ttaacttata ataagattta tattcttcta tatttacaaa aactaaatta
    12301 tctctaaata atatattaaa tttaatattt ttccagtgtt taggtatcct tggttcaaaa
    12361 cttaatttat cattttttat tttcattcct gcaaatccat atactaaact catccatgtt
    12421 ccacccatat tagcagcatg tattccatca cttgtatttt tttgtaggtt attaatatcc
    12481 attaatgctg tgtccataaa atagttataa gctttttcat gatttccaat ttcacttgcc
    12541 atcattccaa atattgacct tgacaaagat gaatcatgag tagttatttt ttcatagtat
    12601 tcaaaatctc tcttcttttg ttctaagcta aactcatcag ggaaaagcaa cgctgaaagt
    12661 acagtatctg cttgtttatt tacttgatat ctatatattg ttaatggatg ataatggaga
    12721 agtaatggat atttttcttt tggtgtattt ttaaaatccc atactgattt ttctaaaaat
    12781 gaatcgtctt gtttgcttat tttcttctct tcatcatatg gtaaatacat attttgagcg
    12841 gcatttatcc agtttttcac ttcatattct tgtaatttaa cttttctaaa tacttcattt
    12901 gaaaataaat tatgcttaaa tttatctacc atctgtactg catatattaa attatactta
    12961 gccattaaat tagtgtagta attattgttt actattgctg tatattcatc tggtcctgtt
    13021 actccattta tacagaattt attatttttt gattctatat aatctccaaa ttcaacccaa
    13081 aatcttgatg tttctataag aatttctaag ccattttgca tcataaattc ttcatcatta
    13141 gttgcttcaa aatacgttct aacaccataa gctatatctg catttatatg aaactgtgct
    13201 gttcctgctg gataatatgc actgcattca ttaccattta tagttctcca tgaatataag
    13261 caacctttat ttattccaag ttctctagct ctttctcttg atgcatctaa gattgagtat
    13321 ctataatcta ataaagctct agcaatggat ggttgagtat atataaaaaa tggtaatata
    13381 tacatttctg tatcccagaa ataatgcccc tcatagccat cacctgtaag accttttgct
    13441 gatatattag tctttccatc tcttcctgct gattgataaa tatgaaataa attggttttt
    13501 atccccagtt gaagagtttt atcgccttca atctctacat cagaggttgt ccaaaactca
    13561 ttcattttct ttctctgaat atttttgact ttatcaaatc caatattaca tgcttctctt
    13621 aaaaccaatt ctaatgattt taaatgtgct tctgattcta aacattttaa cgactccaga
    13681 cattctaatg attttaaacg ttcttcattt agatttaaat cagaatatac tctactatag
    13741 cctacaacaa tttctaaatt taacctttca tcttttttgg catagacttc tatttctcgc
    13801 tcaatacatt catctgaaac attataggtc tcatttgtaa tatttccaca agtaatatat
    13861 gaatcaaacc cacaccataa ccctaatcta cttctttctg taactaaatt cataaaatac
    13921 ttattgttat atttttttac attaatttta aattgcttct tatttataga tgccactctt
    13981 gggtcatcta ctttttcaca attaaacttc tccatactat tttccatttt atttttaaat
    14041 tttatttttc cattaaaatt caatggtgtt attgtatatg aaatcatcat taattcttct
    14101 atatcttgtg atactaatct ttctatagat actttaactt ttctaccacg agagttttcc
    14161 catataaatg aacgtttaag aatcccttca tttaaatcta gtatcctagt atgttcactt
    14221 gtaatacctt ttgataaatc aaagcaatct ccttcaatag agaaatttac tatatgagca
    14281 ttaggtaact tacagatagt ctgattttgt tttgcatagc cataagcgct ttctccatat
    14341 gtaattggag attcttcata aaatccattt acatatgtac ccatattatc tacatactca
    14401 ttattaaaat cagactcttc aatattccct ctaactccta aatgtccatt agctagtgta
    14461 aacaacgttt cattggattt tattgtatcc ttactaaacc ctagctctac aagttggtcc
    14521 ttagtagtaa atattaaact cataataaca ctcctttctt aaaatgaatt atgcatgagt
    14581 ttccatatca ttaaataaaa tttctccatc tgtttctatt acttttttat accaaaaagc
    14641 actttgtttt ttagttcttt taaatgagcc tcttccatag tcatcagaat caacatgaat
    14701 tatgccatat cgttttgtca tctttccttc acttacactg gttacatcta tacatcccca
    14761 cataagatat cctataagct ctattccatc ttcatttact ccaagaatca tatttttaat
    14821 atgttctttc atgtaatcta tacgataatc atcaattatt tttccatctt catttacaat
    14881 atcttgagta cccagtccat tttctactat aaataaaggt aactgatacc tttcatataa
    14941 ctgattcata gttattctta accctacagg gtcgttttgc catacactat ttgattttgg
    15001 aagatatgga ttttttatgg tttctggtcc gtttgccttt gatttttcta aaccttcagc
    15061 tctagctgaa ctacaagcac tagaataata gctaaaagat acaaaatcta cagtattatc
    15121 cttaagtgtt gataaatctt cctcttttat tattaatttt atttgatttg attttaaata
    15181 ataactcata aagcttggat acacacccct aacttgaaca tcagaaaaaa acaaattatg
    15241 cctctcatgc tctaaagttg caaatacatc ttctggttta catgtgtatg gatatgtttt
    15301 tccagcagct aacatacacc caaacttaaa ttctttattt atataccttc ctatttctat
    15361 agtttttgca ttagctaata attgatggtg tgctgcttga tattttttct gaagttgatt
    15421 ttcatcagct ataaaagtta acccagcacc tatatatgga atatgcatta tcatattcat
    15481 ttcgttaaaa ggaatccagt atttgacatc atctttatat cttttcatca aaatttcagc
    15541 atattttaca tataaattaa ccactcttct atcagcccac ccagaatatt tttcaactag
    15601 agaataaggt atatcaaagt ggcttatcgt tattaatggc tctatattat atttttttaa
    15661 ttcttttatt atattatcat aaagttgtaa tcccttttca tttggttcac tttcttctcc
    15721 tgttgggaat attcttgacc aagatataga aaatctaaaa catttaaaac ctatttctgc
    15781 taacattgct atatcttctt tgtaattttc acaaaattta atccctatat gacttggata
    15841 gtattgatta ttttcattta aaatattatc ctcatctaaa catacatttt ttaatctctt
    15901 atcatttaat gggagtttat caaactgaga taaacctttt cctccatcta aataaaatcc
    15961 ttcactttga ttggctgaaa ttgcccctcc ccataaaaaa tctttcccta atttcatgca
    16021 tctacctctt tcacagtata aaattttata atttctatct catatttagt tataagattt
    16081 ttttcatact atacctttta aataattcaa tttaaaaatc caattatatt ttttactcac
    16141 tataattaat attgtctatt ttcaatactt tcatattaaa tatcaatatt agatatctat
    16201 gtatataatt atatatatag caaatacatt tttatatcct cattattgtt atcttattct
    16261 catatattgc tgtatattta tatatataaa aggatttatt tcgaaataga ggttgtattg
    16321 agaactaaaa tttagacttt ataaatgaat ggaattttca ttgttgaaat actgaaaata
    16381 tatttgattt catataaaag aaagtgcctc atgaactaag ttcattttga gacactccct
    16441 tttttctcca agctattata tcttttttta aattctaatg gagagactcc aattttttct
    16501 ttaaatactc tgtaaaaagt ttttgtactt ccaaaaccaa cttcttcaac caaatctaca
    16561 atggatatat tgttattaag taatatccac tttgcttttt ctaatctata ttcatttaaa
    16621 aaagttataa atgtttttcc tgtatttttt ttgaaaaatt tagtaaaata atatacacta
    16681 aatcctactt cataagacac atcttctaat tttataggtt gtttataatt tttttctaca
    16741 tatttgaata tattgttcaa tctctctaat atctctttag agtttatttc atattctact
    16801 gtattttctt caatttctct aggaatctgt ctatataata taggaattaa attatacatt
    16861 ttacctttta ttgcataact atatccttct attttgtata ggtcttcatt gtagatatct
    16921 atcaatatat cgaaaactga ctttcttatt tttgctgacc aatctctact acattttttt
    16981 atactactga ataaattaat taagctttct ttctcctcat ttaataaaat taaatcatta
    17041 aaaaaagata tatcaaattg aaatactaat ctttcacttc ccggtgatgg cagtatataa
    17101 tgaatatctc ctccttttat tatcactatc tcgccttttt ttaattgcat aggcttgtca
    17161 tttataaata gatttactac accttctgtt ataagtaata tttctatttc cttatgccag
    17221 tgtggtgttg ttaatacttc tccttcattt gatagagtac gaaaaggaaa ttcatgtatt
    17281 aatttaggca tttctaaata tattgccata tatatcctct cctctctagt gtctaaaaat
    17341 taatctatac tatttaaaag aatacacatt ttattttaaa aacctcaaat ttataattta
    17401 tacaatacct acacttcata aaatatatct aatatttctt tttttgtatg tgcatttaaa
    17461 agtctttcac ctatattttt accacctaaa atgtaagcta ttttagatat taatatcata
    17521 tcttcattac ctccagattg tggcatagca aacataatta ttacctttac aggtaagcca
    17581 tctatacttg gccaatctac acctttttta gatttaccta ttactatgga tgccttcttt
    17641 acatattttg tttttccatg tggcatggcc atttgataac ctatactagt agagcctatt
    17701 ttttctctat gttttaatgc ctttataaac ttacttttta aagttatact tcctgtatcg
    17761 tataatttat ctactaattc ctgtattatg ccttcttttg tagttgattt caaatctaaa
    17821 ataatgcttt cttctgttaa tatttctcta atttccattt gttttctcca atagattatt
    17881 cttaaataat attttaatat cctctttgct cttgcaatct attatatagt ttatatagtt
    17941 cttttgccta tataaatttg atatttccat taaaatattc tttaaaaaac tttgattact
    18001 aatttctaaa taaatatcaa tcgttctagt aacattattg atattcatta tccctttatt
    18061 taatttactt tgcttatgta tatatatatt taaatctttt cctaatgaaa tagattcata
    18121 tttactccct aaattcacac ctattaaact ttccatctga gctacatcaa aattaaaata
    18181 tatattatct tctaaataca ttcctaataa gtttgtatct aagttcatac tttttttagg
    18241 tttagaaagt aaagcatttt ttatattatt aatatcactt tccattaata gtactgatac
    18301 aactatatgt aatttatctt tcaaatctaa gtttacagta gatattacaa agtctacatc
    18361 atctaaattt cgcttactca actgatgcat aggaactata tcaactatag tccattcagg
    18421 aaattctctt tttaatctgg ctgcaaggag ctgagatgtt ccatatcctg tatgacaaac
    18481 tactattact cttttactac tcatatttct ttctattgcc gcttgaaaat atgtggcaag
    18541 atacgaaact tcatctatac taatattctt cagattatca tactctgtca taatatttat
    18601 agtcatcata cataatccca gcacatctga aaatcgctct tgtatctctc ctaacaacgg
    18661 gttttttatt tggatatcat atcttaatct gtttaacata ggccttacat gagatgctag
    18721 acttttctgt agtaagtcat catttttgag atttatattt aaaaatcgtg acatattctc
    18781 tatcattata gatgaaactt tttcactttc acttaatcta tctgattcat cattgtaact
    18841 actattattt tcgctactaa atccagatga taccaaaaaa atatatatgt acataatttc
    18901 atctttcgtt atttttactc tgtatctatt ttctatctta tctataagtg tagtgacatt
    18961 tttatatact aactcgtcca aattatctac agaaatttct ctttcttcct gagattctat
    19021 ttgattacct tcttcgattc tctttaaaca tataagtata tgggtaatta aatttatata
    19081 gtagggctga tttatagtat atcctaaatt gtattctaat tctgtaatta tagtttctac
    19141 aaatataata gaatcaatat caaataaatt tatcaatgca ctaaatgtag cagaatctaa
    19201 tcttgttaac tcagatatat catgttgttc ataattttca tctaataaat catccatcat
    19261 tttggcaatc gatttcctta tatccacttc tttacctata atcttagttc cttctaaagt
    19321 tttattaagt tttaaattgt attcttttat ccatgcctct atatatttaa aatcatttac
    19381 tatagaagtt ttacttacat aatatttatc tgctaactga tttattgaag ttatattatt
    19441 tgaatttagc aataaatact ttaaaatctc cattcttctc tgctctactg ataaagattt
    19501 attttccttc gattgtatat ttaaactatt aattaagtct atgttcttct ttgctaaatc
    19561 ttctattaat attccatagc ctctttttat atcaattttt atattaaaag tttctaaata
    19621 tttctcaatc atcttcaaat ctttttgtaa agttttatca gatacattta atttatcttt
    19681 aaagtatttt ataggtctat atttattttc gtttagtatc aatttaagaa attcaatttg
    19741 cctcgacaca agcatactta gccctcccta cctatgttta tatatttcta tgtttatatt
    19801 aagtactatt ttaacatatt tactaactat gtaaaattac taagatactt ctgtatcata
    19861 aaagaattta tgatacacct tactaaattg atataataga taatataatt tcaaaataaa
    19921 aattaaggat atttagaaat agttaactga ttctaaatat ccttattatt attctatata
    19981 cttgttgtta ttccattaat tatttttact attatttata atttaagcac caagtaattc
    20041 aacttcacta ttttcactcc ttatagtagg ctttgttacc cctataatca atgctgttat
    20101 tactgtacca atcaatatac aagctatata tgcaactggt gcactacatg caaatggtat
    20161 tacaaatatt cccccatgtg gtgccattaa agttatatct aaactcatac atattgcccc
    20221 acctatacaa gaaccaatta tatttgctgg aatcattctt aatgggtctg cagctgcaaa
    20281 cggtattgcg ccttctgtta tgaaagatgc ccccattata gcagttggta gagatgactt
    20341 tctttcttct ttagtaaact tatttttgaa tattaacata gctaatgata ttgctaatgg
    20401 aggtaccatt cctcctacca ttaatgctgc tgatggttca aatatattac ttgaaaacat
    20461 agccaatcca aaagctgaag ctgttttatt aataggtcct cccatatctg atgccatcat
    20521 ccctgctaat attgcaccta ataatacttt attagttcca gacatacttt gtaaccaaga
    20581 ttgtaaagct tcatttaacc atgatgctgg cgtattaact acaaagaaca ttatagctcc
    20641 actcgtaaat gcaatcaaaa gtggacatat caatacagca tttactcctt ttaatacatc
    20701 tggtaaattt tctgttatct tcattactcc taaagctata tatcctgttg caaaaccagc
    20761 taccatacca cctataaaac ctgaacctcc aataactgcc ataaaaccag ctatcatagc
    20821 aggagcaaat ccttgtcttc ctgctattga tttagctata aaaccagcaa gtatcggtat
    20881 aaataactta aatgctgaat cgcctccaag ttgtccaaag aatccagcta tagggttgta
    20941 tgtttcatga gttgggtctg atgcaaatat accaaacata aaagctatgg ctataccaat
    21001 tccacctatc actacaaatg gaatcatttc agatacacca ctcattaagt gcttataaac
    21061 accctttttc tctgaccctt gaagcatttc ttttgaatct tctaaagtct ttccacctgg
    21121 tttaatttct ttagccattc cattttcagc gtttataatt aaatttttag ctaatgaaac
    21181 attcttagca tctactactt tcttttgtag cactttcttt cctataaatc tactcagttg
    21241 aacttcttta tcacaagcta ttattacgta ttcagctctt tttatatctt ctttagtcaa
    21301 cttattttct acacctatag ctccatgagt ttctatttta acttcatatc caagttcttg
    21361 ccctgcttcc tctaatgctt tttttgccat aaaagtatga gctatacctg ttggacatcc
    21421 tgttatccca actataagac ctttattttg attattacta aaatctcctg attctgcagc
    21481 tttattatta aatatactta atatttcgta tggagtttct gcacttagta gatgcttaag
    21541 aaaattttct tccattagat atgtagctag tttagatata atcttaagat gttcatctga
    21601 acctgattct ggaactgcta tcataaaaaa tgacctaagt ttttgaccat cattatctgt
    21661 aatctctcta tctgttctta aatacatcat tacaggttga tttactacat ttgacttagc
    21721 atgaggtata gctattaaat tacccatatt agttgatgat tctttttcac gtttattaat
    21781 atcagctata aacttttctt tattatttat ataatttcca tggtacaaat gatttgccat
    21841 ataattaatc acatcttttt ttgtttgtaa ttgtttatct agtacaatac aatcgcttcg
    21901 tagtatttta cctatcataa attctcccct ccttttaatt tgttacctca taattaattt
    21961 ttatttttat aaaagcactt taacttatct atagcattga atagattcat tttaaactct
    22021 ataacttctc ttgcagcttt tatacatggt ggatatatag tatctggctc atataagctt
    22081 gggttttgtt ctaatagttc tctgcacttc ttataatatg ccgacttaac atcactcgaa
    22141 atatttattt tacaaactcc tagtttaact gcttgtgcta tttcttcatc tggatttgat
    22201 gaaccaccat gaagaactaa aggtatatct actacttctc ttatttcttt taataaatct
    22261 agtttaagct ctggtttaaa accttttgga tatataccat gtgctgtacc aattgcaata
    22321 gctagtgtgt ctactcctgt tttttcaaca aaatccttag ctaattttga atctgtatat
    22381 attatttcat cagtaccacc ttcacttgat gttcctgttg ttcctattgt tccaagttct
    22441 ccttctacgg acacatttaa tccttttgct atttctacta tttccctaga tatagctaca
    22501 ttctcttcat atggtaaatg tgagccatca atcattactg atgtaaatcc acatcttatt
    22561 gcccttaata tttgttcttt attttcccca tgatctaagt gtattaccat aggtacttta
    22621 ctcttatttg cttcttctat gcaactagct acaaagctat ctcctagaaa acttagctca
    22681 tttgggtgta ttgcaagtat tactggtgca tttttttcgt tagcactctg tactactgct
    22741 ttaagtattt gcccacttcc tatattaaat gctggtacag caaattgatt ttcttgtgcc
    22801 acttttagca tttccttcat gtttattaac atattgtacc tcccgatatt ttaaatttta
    22861 ggttgaattt gcttcttgtt aattttgttg ttgtttatat ttaaataata tcagggtaat
    22921 gaatgtcaga aaataacaat cgttttcctt agtgaaaagg aacttttatt atacactcta
    22981 agttcctttt cactaaataa tttttagaag tctgcatcat agttaattat atttctcatg
    23041 tacatcttct ctttttaagt gttttatgct ttagccttcc tagattttat aataaacaat
    23101 taagatacat taactataaa tttaaagata ctcatgcaat agttaatgct atattagagt
    23161 caaaaaaatt aaaaagatat tagctatttg gccaatacct tttcttggat tccaatagta
    23221 tatacgattt atagaaatct tactcacgat tatctaatgt tttacttcca taaactttac
    23281 ataaaacacc aaagtgacac cctccaaatt catctctagc taataaagtg atttggtttt
    23341 ctaagcacca atttataaat tagcctttgt tatcttatgt aaatcttttt ctatctaatt
    23401 taaaaattat tcctaatgct atatagcata taccaattac taatacacca taagccatag
    23461 atactcctat cttaaattct tgcatattaa ttacaataga aactgaaata gatttattac
    23521 aaacaccata aagcaaggct gacattgtat attatccaat tgtatgaatg aatactaata
    23581 tagctccttt taattaaatg atgctatata aatcatattt atcccaattt ttaatctaac
    23641 ctatttatat gtatattcct ttttaataaa aaaagatatt gactaaatag tcaatatctt
    23701 ttagttgatt taaataccca caattttaat ctaattttta agtgtttcct taacataatc
    23761 ttataaatat taaaatttat ctacctataa aatttctcca ttaaatttta ttacatttta
    23821 tcttaaaaca attataatct gaccttaatc atatattata ttatataaat atttttaaca
    23881 aacttaataa ttaaataact atattttatt atccatctta taaatgttta taaactttcc
    23941 actattcttc ttcaataaat tcaaacaaat tttctactgt agtatcgaat actttagcga
    24001 tatccatagc taacttcaaa gaaggattat atttcccatt ttctaagtgt acaatagtct
    24061 cacgtcttac cccaaccaat ttagcaagtt cattttgcgt cataaggagt ttttctctgt
    24121 attctttaat ttttgttttc atcaatattg ccacttagtt acatatcccc cttttatcaa
    24181 agtatatata caacactaat ttagataaag actgtataaa taaaactgca atgaggatta
    24241 tacctgtatc taggtttgat atatttatat tacttgtata aggtgttgca aagaaaatag
    24301 atattattac tatagaatat atcattattt ttattgcaat cttattaacc tttgatagta
    24361 taaattcaga tgattcatca actaaatcat tatatttttt attataaatt gaataacatc
    24421 caaaaactat taaccaactc aaccctggaa gagaagcagt gcttggacct ttaaaaatat
    24481 acttagtggc taatacagct ataaaaaaat aagttattac aagcaactcc aggataagct
    24541 ttgatcttac accagtttct gatttagaca tataaaatca ctccttaaaa attatattct
    24601 ctatactctt taattttcgt ttttatcaat attatcactt agttgcatat tccctttcta
    24661 tcaaaatgta tatacaaaat taatttagat aaagattgta taaataaaat agctaagaga
    24721 attacaccta tatccaaatt tgatatatcc aaacctcttg tataatttgc tgaaaagaaa
    24781 acagctatta gcaaaataga atataacatt atttttgatg caatatgatc aacctttaat
    24841 aacataagtt ttgacgcctc gtcaactaaa tcattatatt ttttattata catgaagtca
    24901 catgcccaaa aagcgaataa aattataaaa gtaatacaaa gatttccctc tttaaaaata
    24961 aactttttta ataatgagtc tataaaaaaa taggatatca taagtaactc tgaaacaaga
    25021 tttgttttaa caccaagctc tgatttagac atataaaatc accccttaaa agttatatat
    25081 ttataacacc ttatgttata aatatataac ttttccaaat aaattgcaat agaatattga
    25141 aaatattcaa taatatcttc ataaatatat tttataaaag attttataat aaacattaca
    25201 atacagtact aaattagttt atttcatcta tcatctcaat catatcattt actaactatt
    25261 attctaatga gcatataaca ttgaaactta taattataca acctaaatgc ctcccaatgt
    25321 accctcaaaa catcatttcc tgtaactgaa gtataattgg tatattttat cactgaaata
    25381 aaaaaacact agtcaataaa gactagtatt ttcaagtatt ttatcattct ttttttaatt
    25441 attggagacg aatcatcaga ataatgccca taatttatct atatgcaaat tctaaattta
    25501 aaataaagtt tcagataaat ttactattct atgctatgat acaacagaaa aaactgaaat
    25561 ctatgagtgg tagcttcata taatcctagt tcctacagta atcaaaactg aggtttattc
    25621 tatatgtaac taatgataaa ttttattata ggagttatta gatctatttg tgttactata
    25681 agtagtaatt atatatatga taatttttta acacttttct gttggctata tagaaagtgg
    25741 tttagaattt aaatttaaat aaaatttaaa ttcaccaaaa agaaatctat attagaaacc
    25801 actactctat tccaccagat tgtaattttt tgttctttat atcacaatgc tataccatat
    25861 taaattgaaa aataagtttt aaatttattt gttacaattc attaattcaa aaaaatattt
    25921 tgagtcatga gttttgtaaa gatttagcca tgaatttaat gcttctgatt caaaaacatc
    25981 taaaagtttc aatacttgaa acgtaaattc caacggagca attcctgaag ccgtaactaa
    26041 attttcatca ctaactacag attccgtttt ataatatttt tctccagagt aatttggtat
    26101 taccatttta agaaactcta agtcattact tgtatgattt ctaaaatcta atagcccttt
    26161 tttagctagg cctaatgtag ctccacatat ggctgcaact atagaatctt gtcttaaagc
    26221 ttctttaact ttttctaata ttatctcatg attcatagat aaccaagtat ttccccctgg
    26281 caaaattaat aaatccttac tttccatatt aaactcatca actgtaattt caggtaaaac
    26341 ttttaaccca cccattgtta taataggatt tttatcaatt cctacagtaa ttacttttag
    26401 tggctttaat ccttttttaa aatatcttcc tgtatttaat tcagcagtta aatatgccac
    26461 ttcccaatct gacatagtat caaatacata catatatact tttctatttt tcatcttttt
    26521 tactccttat gtaattaatt tatatatcta attataaaat aacttaactg acatattcag
    26581 tcagttaagc tattaaattt gataataatc aattaattct agtaaatctt caattatttt
    26641 cttcctaagg cttagtggtt caattacttg tattgtcttt ctataaggta aaagtatatt
    26701 tggtatgtac ttgcatatta cttcctcttc aagcataaat attattttat taggtgttct
    26761 ttctttcaag tagtgcccta aaaaccaatg ttggcttaaa ctatctaaag aatctatact
    26821 cccttctata actaattgaa ttatattttg ttcatctttt atttcaggta taattccttt
    26881 tataaaaaat tcacttgctg aaaattctgt cggtctgtta aatgtatttg atgtttctat
    26941 gatttcacta atcctatcca ctctgaaact acgaacctca tttctcatat tacaaaatgc
    27001 aactacgtac caattattat tccagtgaac aattccatat ggatttataa ttctatattt
    27061 tgattttact ttacgacctg catgatagtt gatttctaca gatagctcct ttaatatact
    27121 attctccaat tttttaagta ctgattctat agacactttc ccaattggtt ttattacttc
    27181 aagggctctt aagtggtttg ttaaaatatc ttcttgtttt tgatttgaat acatttttaa
    27241 ctttaatatc gatttatcta atgcttcgtc taagaagtat ccttcttttt tagcaaatag
    27301 tgctgcatga agtagagatt tttgctcttc tatatcaaaa aaaagaggtg ctttagtaaa
    27361 attatttaaa aggctatacc caccattatg acctgtatct gaaattatag gtactccact
    27421 cgcagaaagt acatcaatat atcggtacac tgttcttata tttatttcta atttttcagc
    27481 tatctgtttt gctgtaattt ttttgtcaga gtttaacatc cacagtatag acatcatatt
    27541 gtcaatttta gccatgtagt ttcacctctt tctatttgtt atataaagtt attatataac
    27601 tttttgattg attttttaca aaaaaacatt agtaaactgc taataattta tactaagatt
    27661 tatttcaaat atttatagat agtctttttc tatagttaag ttatccatta aattacatag
    27721 tagtatatct attttagttg atatattttc agctacctcc cttgaatatt attacaataa
    27781 gtctaaatct tctttcttcc ataaatatat tatgaggaaa gactatcatc tttaatggtt
    27841 taatagtata aaagatatta atttaaaaaa atctattttt atatcagatg ggtattgttt
    27901 tttataaaac tgaaaaaatc acctaataga atctatgatt ttttaacata acctccataa
    27961 attagttcca attatcactt caaattcaaa tttttatctg aagaatatac aatcatattt
    28021 ccatactcaa cataatattg agtgtttggc ttgtatttac aaattattat tctaacaaaa
    28081 acaactatac atagattaaa atcatcttct aaacataact actaaaattg aattaatgat
    28141 atcaattcca ttaatctctt ttaataaaaa attctctttt ctatatgaaa attatttcaa
    28201 aacttttaag ttaaatacaa aaatgactat aaatagattt ttatttacac aaatctattt
    28261 atagtcacta tagtttatcc aataaaataa taaaataaat atgtacacaa taaatgttat
    28321 ttacgtctta agtatttatt tgttagattt ttaattaaaa aaaacaagct aatgaacatt
    28381 aatgctaaat ctagcattat attgctttga tctcctgttt gtacattttg acctacatta
    28441 ctatctaaac tttcatctgt atctatattt atatctggtt ttccattccc atctgtatct
    28501 atatttatat ccggttttcc atctccatct atatctatat ttatatctgg ttttccatct
    28561 ccatctgtat ctatatttat atctggtttt ccatctccat ctgtgtctat atttatatct
    28621 ggttttccat ctccatctgt gtctatattt atattcggtt ttccatcccc atctgtatct
    28681 atatctggtt tgctatttcc tccattatct gggtctggtt tactatttcc accgttatct
    28741 ggatccggtt tgctatttcc tccattatct ggatctggtt taccattgcc accgttatct
    28801 ggatctggtt tgctatttcc tccgttatct ggatccggtt tgctatttcc tccattacct
    28861 gaatccggtt tgctatttcc tccattacct gaatctggtt tgctatttcc tccattacct
    28921 gaatctggtt tgctatttcc tccattatct ggatctggct tatttagatt tggattacct
    28981 gtatcataac ctcctgagcc agtatctaca tttttatcag gcttccaata atcatctact
    29041 ccatcattat ctgtatctat tgctggacga ttataatctg tatcagggtt tccatctcca
    29101 ttggtatcta tatttttatc aggtttccaa ataccatctc catttccacc ttctgtacta
    29161 ggcttccatt cacctgtatt atcagtatct atgttaatat ctggcttcca atcaccactc
    29221 gtatctatat tgatatctgg ccttccatca ccatcagtgt ctatatttat atccggtatt
    29281 ccatccccat ctacatctac atttgtcata tctaacttta acttcttttc atcctcacta
    29341 ccttcaatgt aatttatatc atctccaata tattttacag taatagtttg ttcagtagta
    29401 aaaatatgat gattgctatc taaaggtctc cattcaatag atgcagtact ataattatga
    29461 ctctcactac ccttattatg agtttttaat tctactggat ctttatattc ctttccatta
    29521 atatagaatt gtacgtaacc tcttggagag gcacaatctg gtccttcttt cttatctggt
    29581 gaaatagtaa catttaatgt aaacgtatct gttggtttaa aaacatcagt tttagcttta
    29641 gactcttcta caactaatga agtttctgta tcagcaggaa taatttctgc cttataatat
    29701 gctctatgcc cccaataagc atccttaaaa ggatatatac tcgaaaactg tgttgatgta
    29761 atgcttaatt gatatttccc agcatcaact tgttttgtaa gatcatcact tcctaaattt
    29821 atatctggtt ccatcgtttc ctcatttaaa cgttgagaac taatagtcat aaatttttta
    29881 tctgtgagtt tttcaccttt aggagtaatt attggaatac caccatcttt aaatatccaa
    29941 tctaaaaatg atttttctac gtcttcttca aatggtaatc catcatatct tttaataatc
    30001 aaatatggtg gagtatcatc aatagtaaat tcttcatatt gctttaaaaa ttgagaacct
    30061 gaacctatat ctttaatata aaaatcatct ggttttagaa cttctccagt aattttatct
    30121 ataacaacta aattaacaga tacttcagat cccttaaatt gatcagagaa ccataagtaa
    30181 agaatccctt gagcatctgt ataactaggt gctccataag gataaatttt tccatcaatt
    30241 agcattttaa aatcatcaac tagtgtagta ctaactttat cttgccctaa atacgttaga
    30301 gatattttat tcataaaaac ttttgttttc ttttctaaat caccgtatgc aactgctcca
    30361 cctaaacttt tgaatgttgt tgcttttaat gaaccacctg ttactataac atctcccgtt
    30421 gtagcactta ggtcaaaaat ccaatctccc actcctgtca tataaggtaa aatcgttcct
    30481 ccagttacaa gtatacgata tcctctattt gttcctggat taacacatcc atccccaaat
    30541 gcactaccat gtgcacctcc atatgaatag gaaagtccac cattaattgt aatattccca
    30601 ctataaccag aacctgtgct aggatctact actgagggac ttaatgcatt ctttgttgtt
    30661 gtatagtatc ctccacctat tccagctcca tggtatgcac ctttagcagt tataatacct
    30721 ccattgattg tgatatctcc accactacca ttaccgcctc cacctattcc agctccatat
    30781 cctgtattac gactcgattc ttgacctata gcagttatag caccaccatt aataataata
    30841 tttcctccac tttcagtatt tccaccacca atacctgcag aataataatt tccaacaact
    30901 tttaaacttc ctctattatt actatctagt agtgtaaggc gatctccttt ttttaacttg
    30961 tctccatttt ctagagttac atctctagga atttttccac cctcaggaac tataaactct
    31021 ccttcaatat ctctatttac aacagaatca tcaataatta gagtagtacc ttttcctgct
    31081 ctcatacctg gataatatac atcacctgac tctagcttgt tttcactacc atcttgtaat
    31141 ataacatgtg catatgcacc accatcttta tctggtgtta aagtaaatgg gctattagat
    31201 gcagttttaa tatttactcc atcaaatatt aattcagctt ttacatcttt aggtataaca
    31261 atcctatgtg ttgttggagt atttggattg ttattttgaa ttgtcatttg ttttccacta
    31321 agaatagtta aaacgccact tgcaaattta aaatcgacat ttatttctcc accactaatt
    31381 ttaaagtctc ctacagacgt aggctcttct gcagtggctt cttcttctac aactactgca
    31441 ttagcatctc cttctgcatc tcctgcatta gtatctcctt ctgcatctcc tgcattagta
    31501 tctccttctg catttcctgc attagtatct ccttctgcat ctcctgcatt agtatctcct
    31561 tctgcatttc ctgcattagt atctccttct gcatctcctg cattagtatc tccttctgca
    31621 tctcctgcat tagtatctcc ttctgcatct cctgcattag tatctccttc tgcatttcct
    31681 gcattagtac ctccttctgc atttcctgca ttagtacttt cttctatagt atctgcgaaa
    31741 gtatttgacg cattaaatga tgctactggt ccaagtccca ttgagatact taaaatcatt
    31801 gatagtgctt tctttttaca tttttgttgc ataaactccc cctcccctta ataattttta
    31861 atatacactg tatacatcct tatatacact ctaataattc ttaatatacg ctgtatacat
    31921 tctaatgcac actctaataa tttttaatat atacttaaaa cttatatttg tcaatgaata
    31981 tactgttttt tcaaccttat atattataag tattcattat ttgctaaata actacaataa
    32041 aaattttaat tatataaaat ttatttaatt ttttatataa taatactaag gggtaattaa
    32101 ttgaaaaaac tagtaaaaat attaataaat attatttgca ttattacgct aattttctct
    32161 agcctttcga tttacataaa attatctgaa tataaaaaag ctgatgaagt atatacggaa
    32221 ctcagagaaa acactatcaa taatagcaaa catcaagaac tttatgataa aaataatgat
    32281 tatagattct ggcttaaaat aaacaacgta aatatagact atcctgtagt acaaggatat
    32341 aacaatgatt tctacctaac tcatgatttt tataaaaatt atcttccttt aggtagtatt
    32401 ttcatggatt atagaaataa ttttgaaaat gataagagtt taatagtcta tggtcattat
    32461 atgaaaaata aaactatgtt tggtcagcta gaaaactata ctgatgaagc atttttcaaa
    32521 gaaaataact tagtagaaat aaattataaa gtacaaactt atacttatga aattttttca
    32581 gtatatactg ctgacttaat taacagagat tatttaagta tacactttaa tagtaattat
    32641 gagtttaaag attatttgaa ttatataacc taaaaatcag tacacaaatc tgatataaag
    32701 gtagatattt cagataaaat tataactttg tatacttgta actatgaatt taaagatgct
    32761 cgtactatag ttcatgctaa attaatttca aaaaaagaga ctgataagta ggtttgtgta
    32821 aatgcagact tacctacagt cttttttgaa cgtaaaatta gtaagtatgg aataatattc
    32881 atattaaact tttgtaggca aagaaatgaa aaatcaaaga gaaataatta ttacagattt
    32941 agattaccaa gctgaattaa gaaagtgtaa aactatggag gatgtagttg gtgaagatag
    33001 tatataatag tttaacttat aaattatctt ggtgatatta atgaagtttc aaagtatata
    33061 ttatttattg atataaataa tattaaatct gttgctaaca gatgtacctt tgtttggaga
    33121 caaactattt aagaaatata actaaaatgt tgaagtagct acctgacttt attttgaaat
    33181 gcgaacaaga ttttggcatt aagataattt agaaagaatc actggtacac aaggatgtga
    33241 acttagaatg aatagaagta ttcaggcata aggagctttc acccaaataa aacatagtat
    33301 gaactttaaa agaattctaa tcagaggcaa tcaaaatgtt ctttcatagt ttatacctgt
    33361 agtgttagac atagtattta taagtttcac aaataagata atcattaata aatgtagtat
    33421 gtatattcat cctctcaaaa atatttttta atcttacact ttgtaaatta ttctatttta
    33481 aaatggtatt tttatacctt tatttcttat gaccgttttc aagctcaaat tttgcataaa
    33541 tataaattaa tgaaaagcaa gtaaaaaaag aactgtcgca cagcaattta aaattactca
    33601 ttcgacagtc cttatttcgt ggatttaaat agtggagaag aatcacaaga ataataccca
    33661 cgattaaacc tttatacaat acattttata tgactttacc atcactaata gttattatac
    33721 aatcagccat cttagctatt tcatcattat gagttatcat aaccaacgtc tgcttgtatt
    33781 catttacaca atactttagt aaattcatca cctcattagt tgttttactg tctaaatttc
    33841 cagtaggttc atctgcaaaa attattgatg gcttattggc aagtgatctt gctattgcaa
    33901 ctctttgttg ttgaccacct gataattcat taggaaattt attaatctga ctttctaatc
    33961 ctaacttagt tattaaatca ttaatataat tattatctat ctttccttta gcaattaaaa
    34021 taggaagaac tatattatca taaacattga taacaggtat tagattatag ttttggaata
    34081 taaacccaaa ttctttactt ctaagattag atagcttttc atcacttaaa gtatataaat
    34141 ctaaattatc cataaataca ttacctaaag ttggtttatc aagccctgcc atacagtgaa
    34201 gtaatgtgct ttttccagaa ccactttgtc caattattgc actaaattta tggggttcta
    34261 tctctaaagt aattccatca acagccttta tttcattttc tccttttcca tatatttttt
    34321 taatatctat aacttttaac atcttcatac atttacctcc caaattattc attctctttt
    34381 ataccttcaa taatattcat actttcaaaa tctctattac ttacaactac tgatattaaa
    34441 catacaaata cagatatagc aaagaatagt aaagattcct taattgggaa tgtaaaagac
    34501 ataaaattct ctattccata gtttatatac gcatcattat tccaatttgt aaatttaact
    34561 agatttataa atgatggaat catagctatt ataaagctaa aaactgcata tgctaatgct
    34621 tcatatataa gcattttttt catattttta agactaacac ctaatgctct aagcgttgaa
    34681 atttcttttt ttctaattag tagatttgtt cttatagtac agaaaatatt aattgatgct
    34741 attattaaaa ctagtgcaat tattgctatt tgtgatttaa tgtaactttt atatatactt
    34801 tctgacattt catgataact taatctacta ttaaatagag accctggtat acttcttgaa
    34861 attttctgta tctcattatt aacaatctca tcatatggat tttctaaatt tatgcctaat
    34921 tgagtgtatt tttgttctcc tgttatgttt ttagagtgaa tattacttgt tataatttct
    34981 agatctggca taaaatcgcc atctcccata gcaatccatt catcctttaa aattacagcc
    35041 actcttacct tcatctcttt ataaacaatt gtattatttt cttcaacagg aatttttaca
    35101 gttattatgt ctcctatatt taattctttg aatataggct ttatagtatg atcatcaact
    35161 atatcataaa aataattata tactgctaca tttggatatc catcagtgtc ctttttaata
    35221 tcatctaagc taccttcttc aacaaagtca tttaactttt catctatata atcatcatca
    35281 taaagcttta aaactaattt atcttccatt atctcttttt tttctactcc attataggtt
    35341 gtaaattctt tgtttatatc cttattatta aaagtaaaca ttccatttgt tatttgaatt
    35401 ttatgtatac ttttaacacc cttaattttt tctatattct ctacatcact atctgtgtat
    35461 tttgatattt gcgggtctgc atttactcca aattgcattg ttatattata tctattttgc
    35521 atatcttcaa ttttactgtt gacctcttct tgcatacttg agaatgtagt aatgaatata
    35581 tatcctccta aagcaataga caacatagat atagcagctc taaccttatt tcttccgata
    35641 tttttaagtc ccataaatcc ataaaatcca aatattttgc ttactagtct gtctattcca
    35701 agtctacttc tgtgattttt aattttgtct gtatttatta ttgattcaat aggtgatatc
    35761 ttgccgattt taaaagttgg tataatacaa gatataaaaa cagaaatcat tccaaccaat
    35821 atagctttta taactatttc attatttata tataatttag ggttaagacc agcttcactg
    35881 tataaaactt cgttataatt actaattcct atatatgaat atgtaacccc agctactaac
    35941 ccaagtagta tacctattat tgttataatt aatgcttgat agattatcat acaccttatg
    36001 tttcttttct ttgcgcccat cagtctaagc agtcccattt cttttactga ttgatttagt
    36061 gtaatattga aaatattaaa tatgaaaatt atagatactg tagttattaa aacatttctt
    36121 ttaaaaacat tcggatcatt cttatcatct tctacataac gaagttccct tacaagaggt
    36181 acatttggta gaaaactttt ttgtcccaac ttatattttt tcataagata atcacattca
    36241 ccttcaatat ttctccatcc acttttaaaa cttaatatac tattataact aatcgcatca
    36301 tgaggtataa tgttatttgt ttcatcattg ccataagtta ctgcttcgta ttgccaaacc
    36361 acatcatagt acccttttgg tttttccata actcctacta ttttaaattc tttatttata
    36421 gaaaataatt gattacttcc gttagtatct ttatagttct tttttattgt taaatttaat
    36481 gtagatccta ctccttcact taaattcatt gcttctagtg cttttttctc taatactatt
    36541 tcattgttgt ttttaggtag tctaccttct attattttgt tgtatctact ttttagatac
    36601 tcttcgtttg atgaagttaa tataaatgag tttccttttt tatctgaaat acgtcctaga
    36661 ttttgtaccg aattaccctt tgatactttt tcatcagttt ctaatttttt agcatcatca
    36721 agtgtcaaat cactaaactc tacatggtat ccactgtaaa gttcatgtat tgctactaca
    36781 ttgttttcat tttgtgaatc ttttataaca ctaggtccaa atatcaacat aacacctaac
    36841 ataactccta ttattaaaag taatgttcta agtttatttt tctttaaata tgctagtgac
    36901 atttttaagt aaatccccat ataatcctcc tattttacta taaattattt atccaactca
    36961 tctgttaagt agattggtgg atattttaaa tcttttaatt cttcattatt ttttgaagct
    37021 tactaccatc ttcctcatga taaacttgca gtatcacctt atttacatgt agtgcataat
    37081 aatcaccatt ataaaaatat tagtatttat aacctggata atttttgtaa aatgatttat
    37141 aaagtatccc atcctaattc tattttgtat acttttcttt tgtaatacgc tctatatcat
    37201 cacctgaaac tccttgatat gtcatatatt tatctatata tttttcagct tcattccatt
    37261 ttctaaaata gttgttgtat ataataaatc ctattatggc tataatgctt ataattaaag
    37321 ttaataaaat agctttgtat tttctcatag tgaatcttcc tacttcaatt taaattcttt
    37381 aataagtttt aattctaaag acttagtttt atcatcaaat ttcttaactt gaatttttat
    37441 atctcccaaa ttatcaacct ctacatttac ttcaccttta tcaaatactt cttcaatttt
    37501 tctaaaaaat tctttctcac ttatttctat atgaatcaat gatctatatg ttataaatgg
    37561 ccattatgaa tttatcatct tctgacagct tttcattata agaaaaatct ttaacacatt
    37621 gaattgataa tatttccttc gtatccttct tttccttagt tattgaataa tgtaaaactt
    37681 ggctaggttg ttcttttgta tactccaagt ttcccaaaga caaaacaaaa cttccatctg
    37741 atttattttc agctacccta agaccactat tttctattga ttctgatatt ttctttgaca
    37801 agtcttcttg atactagaaa tctgttcaat agtatatatt ttttcatttg tacctgaaac
    37861 cttatttgtg catcctgtta ttaaacctag tgttaagctt atagctataa ccatagttat
    37921 tgtaattttt ttatcttcat ataatcctcc ttatatattg aaaactcgtt atttctcata
    37981 aaaaaaagac gctatctttt tctattaaaa gataacatcc ctatatgttt agtatcaata
    38041 tatgttcccc aactggtagg ttaatcgacc caactatcaa aattttgatt taatggtata
    38101 taaatattca atataaattt gtctttttta tcttcaaatg ataaatc
//
LOCUS       DAEHWM010000032        37501 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.033, whole genome shotgun sequence.
ACCESSION   DAEHWM010000032 DAEHWM010000000
VERSION     DAEHWM010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 37501)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 37501)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..37501
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.033"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            46..444
                     /locus_tag="KNP36_001680"
     CDS             46..444
                     /locus_tag="KNP36_001680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0873558.1"
                     /translation="MDTLGKRIAYLRNSKKLTQRKLMDILKFENLGKYETGDRKPNCD
                     ILMSIADYFNVTTDWLLYGKEKVNVNSSVKEDKEDYLHVTNDEMTILNLYRQLNERDK
                     IKIEGILELKISEYKDLKKHSSNNNEDKMV"
     gene            complement(661..870)
                     /locus_tag="KNP36_001681"
     CDS             complement(661..870)
                     /locus_tag="KNP36_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873559.1"
                     /translation="MCKLDSDGVIECCRAIDDFITALSNIKSLNMERLNTLTKYSSTC
                     SILLKEGNYEGCTIVYRKMLEELKT"
     gene            complement(902..1111)
                     /locus_tag="KNP36_001682"
     CDS             complement(902..1111)
                     /locus_tag="KNP36_001682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873560.1"
                     /translation="MDARKKWIPFLGVQVKQRLIELNMTQRELAKKIGVNENYLSAIL
                     NGRRTGKKYKSSIYQLLNIEYSEDD"
     gene            1410..1829
                     /locus_tag="KNP36_001683"
     CDS             1410..1829
                     /locus_tag="KNP36_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873561.1"
                     /translation="MDTLGERIVYLRKAKNLKQYELEEMLGCDNLSKFERNIRKPNYE
                     ILKSIAEIFNVSVDWLLNGDNLSHKSDLICDSSSNYPLNSINSNEIKLLNNFRKLNDY
                     DKAKIEGMIELKLHEYEKEKDLGKIEYNKNKDEKIDK"
     gene            2057..2512
                     /locus_tag="KNP36_001684"
     CDS             2057..2512
                     /locus_tag="KNP36_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873562.1"
                     /translation="MGLRDKFAQSFARSKTMSGPEKKANEIMGKLLLKKAILPIVLMF
                     VIIIAGAMLKINSWVTLGINLVIAVGAFFYIRNSSKKYQNFKPYVGNLISLEKKGKKE
                     YVAIIKQGKLPVKLQIAYGGEDLEHVKKNQMVQISYNPDAKIAILVNRQ"
     gene            complement(2733..2993)
                     /locus_tag="KNP36_001685"
     CDS             complement(2733..2993)
                     /locus_tag="KNP36_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873563.1"
                     /translation="MDKLITELSSLGAIGILCALLFKNTMQEKKEDRDMYKKTVENFI
                     ELSTQQQEINKNILVQMGIMKTDVEEIKEDVTGIKGMLQNGV"
     gene            complement(3256..3609)
                     /locus_tag="KNP36_001686"
     CDS             complement(3256..3609)
                     /locus_tag="KNP36_001686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873564.1"
                     /translation="MFKFDKNKIEQIKQGRKVEMQYKDISDISIGQVKQDDDITNNFI
                     ANAEIYEMLLNQSSVNEASNISSFSVRKSGGESGMVEVYVALILRGKKTIEEVPAVIR
                     EQVRIRCKELEIPVE"
     gene            complement(3626..8947)
                     /locus_tag="KNP36_001687"
     CDS             complement(3626..8947)
                     /locus_tag="KNP36_001687"
                     /inference="COORDINATES: protein
                     motif:HMM:NF012632.1,HMM:NF024930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873565.1"
                     /translation="MKRTKLLQRGNFFGDKNMVVDEFDEGYDNYDFINFFTGCCNYTF
                     GLKNNNILYGCGDNSNFQLGLGEDNTTRKLFTKIPNISTNIKKVACGESHAVILTSDG
                     ELLVAGINTDGQMGLGLEKVGKTVSTFEKVPEIKGVKDIACGLQSTYLLYNDGTLYVA
                     GNNLYGQLGLGTNGASANVNTFIKVDVDNVKAVFSYNKSAFIIKNDNKCYSTGFNNQG
                     QLGLGDKNNRDLFSLVSINDVKTIACGSEHTVLMTYNNDIYGCGKEKCFGNALQSSLF
                     TKIEEVNIKTIACGNGNTMLIDNKGILKVAGNNDIYQLGIANYSENIDNSFIDLKNIV
                     AKNIFIGLSHSILIDSNNDSYCTGDNTYGQLGSFFDDMHIVEFKKMDSEKYSYSNYIN
                     LIKSEDKLTLLKEEMEIKDIELPLDIHSVRDVVFSPYCTLVILGNGDVYGLGNNRYKG
                     MGSDLPSQLNELTKLSISNVKSIVASKNISGGIFYIKNDDTCYYSGPNSNSIAGVLPS
                     NSDIFKKISIDNVKKVVINTDLSNWFSLIVTNNKQIYTSGKSSSYVNGLSNKSASQYT
                     EIGVSNVTDAYSSYNATFIVADEKKVYATGINTNYLLGVNPNDGVNINLTLINNWFYV
                     NPSGASYSTNSCTNDITKINNIIIYEYMAILCTNYGSFLTGYHGTLWTKPSDSTYRVQ
                     QQGITHAGYISNYIYNYYPTRCTQSSYSTNFAYLYYGESTSNLKNVNPDNLLISGGSS
                     YIHQYGRNYLNNQSSNNIAASNINSGPITSDKAIFLYKALLYLSSNTLYGFGNISESA
                     KELDVSDTQDGYNATNYKKVMKNIKNIFIPPYDLSRDKTRFAILTDKSLFICGYNSKG
                     THGISVNSSLNLNNKINYNKKNSSSEISSNIQEIYSHSKSTYLLTNNNMLYSVGLNDV
                     GQLGVGDEINRKVFTKINIDNIKSINVNRFTDNSKHVFAIKNDNTCYAVGLNNSGQLG
                     IGDNVNRNVFTKINVENVKYVAVYGNTSLLLTNDGLLYGAGNNGKGQLGLGDTTSRNI
                     FTRIPINGVRDVYICNDVSIIVKNDNTCYVCGFVNGYFGFTEGSISTFTKINIENVKS
                     VVTAGSEATFFITNDNVIYTTGKKERVFFSTETNDIKGIRVINNIINAKKIVVNGYTS
                     AILTNDNKLFVGGLSGYGSIANNNNTNSVEDVKDVFVTANNTLYIDNNNNLISSGRDT
                     YGISDESYRDMSVPYYKVSIKKDVDTVFSSYNTIFIKDIYGKFYSSTGDNRYNHLGIH
                     HRYDNDKNEALEGSLHSYFKTDNTSDKIVFNKKNEKLVMFNDKYIKTNNKYINYKNIF
                     KDNFKYTSIILPFEVSDIDISKTHSLAVAKDGKLYGIGSNSYKEINQTLEDIELLTLT
                     EVNISDVKKVACGDNYSYIIKTDNTLWSYGKNTEYQLGVGHNNDVRELQKVTGLPSVK
                     DISIYNSMTLVLTNEGELYAQGYNTNGLFGLGESEKDKIIRTFTKVLTNVKEIKSHND
                     DHILVIKNDNSLWITGKNKSMYKISISITDLYEFTKIPIPEHLNDILDIELSDDTIYM
                     ITKVDTSKASIEIVEKSISQVRVVVQDPNNVIEKLEMFINDELISTKTNLEINSIIFE
                     IPQNKIVLGENKILIKASSPTGDLYSSMFIFKSETGLKVKKDSILMINNKVYSIINIT
                     ENNTDLIVTLNEGLKDDMMENNPIYQLINKTKVQVKINKSDLFKDMKLVEIKKSDSSY
                     QEIYELEEANIKSAQPKIIVEKGDKWTAIKRPSMIFRYDAESNEPQA"
     gene            complement(8964..9947)
                     /locus_tag="KNP36_001688"
     CDS             complement(8964..9947)
                     /locus_tag="KNP36_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBF0873566.1"
                     /translation="MEEKFYIILTKIGREKIANATALGELVGLTKFQVGDSNGEYYEP
                     TEEQTALKNVVWEGNINSLRIDEKNPNWIVIETILPGTVGGFMIREAAVLDNENNIIA
                     IGKYPETYKPRAEDGSIKDLVVKMILQLSNTSNVTLEVDPTLVFVTQKDIQDLDDKVD
                     KNIKEIKVKIGEELLSTEAKNLSGAINEVVEKIKNISIDDVIGGQIQTELSVLKNSYN
                     KLSEKVLDILIYLELESEIDVDEAGYWYDTLTNAKNIIAIEGLKLDLNRKCITGELGS
                     VTFKNVVLPFNANRVRYIHEMDNNFVETKSNRAYSIGQTDITLNKYSYEIR"
     gene            complement(9948..10646)
                     /locus_tag="KNP36_001689"
     CDS             complement(9948..10646)
                     /locus_tag="KNP36_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2313 domain-containing protein"
                     /protein_id="HBF0873567.1"
                     /translation="MKLIDKLPSFDRNYIVEEIQGAYDTELNILKEDIDDTFNQLFVD
                     TATWGLDMWEDILCIEKKELDFDTRRSNIKAKMRSRGTSTIEVIKSICEAYTKSETDI
                     KVYSDEFTFVLSFIANNCDYKTLLDCSDMIERVKPAHLLHYLEPIILDKSMVYCGGGM
                     VCSEEVKVHPYFEPIIKCSAVVNCGAGMLSREEIKVYPLSIKCIENNCKINIAIANDT
                     GVENVVVYPKSEVV"
     gene            complement(10643..11695)
                     /locus_tag="KNP36_001690"
     CDS             complement(10643..11695)
                     /locus_tag="KNP36_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBF0873568.1"
                     /translation="MYSDQTYEVIKNRTLENINLDIYKGEGSFLNNMVSGNNLELSKI
                     YLELSKIHKMAFIQDTYNQFLDKRVNEFGVYRKLGTESNGEVEFIGEKGTVINNGTII
                     SYRDLLFVVIKDVTIGSEEGDNSPVQALEVGKKYNLPTNCEFKLVDNISGVTKITNTR
                     SFEGGTDIETDEELKERFYKIQRNQATSGNKAHYEEWALEVDGVYNVKVYPRWDGPGT
                     VKVLIFGKNNQAVDTETIERCQQHIDEEKPIGPTITVVTPLPIEINISAVMKLEDGYT
                     LDNVKESFLESINTYFRDIRGEIIYTKVMGILINTTGVHDLSNLLINGSTDNITINED
                     KIPSVTTVNFSEVENQ"
     gene            complement(11688..12116)
                     /locus_tag="KNP36_001691"
     CDS             complement(11688..12116)
                     /locus_tag="KNP36_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBF0873569.1"
                     /translation="MSTIFPFIGVPEDYILPKTEELPIFREVAWDFEKDEPILEKGDF
                     KIIEKKEALKVWIYKCIKTNRYEHEIYSLEYGTELSELIGQKYTKGLTESEASRFIKE
                     ALLINPYILEVNVKSANFNRDVLSANVKVSTIYGEVEINV"
     gene            complement(12116..12442)
                     /locus_tag="KNP36_001692"
     CDS             complement(12116..12442)
                     /locus_tag="KNP36_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2577 family protein"
                     /protein_id="HBF0873570.1"
                     /translation="MANPINEFIGIIREEGKYHNQPSFFIGKIKSKLPDLKIETNNII
                     LEKEDILIDSWMIDRQLETFDTETNQEHQHEVKNPFIDNFESGDMVIMFRIGEKFAVV
                     SKLVSL"
     gene            complement(12458..13987)
                     /locus_tag="KNP36_001693"
     CDS             complement(12458..13987)
                     /locus_tag="KNP36_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBF0873571.1"
                     /translation="MIINRSKDSSSNEISFVSKDMGFLLTQSEVSYNFKDKLVEDIAK
                     QVFAENRLSVGTIAKTNVKYTKMFIGVNGYDTIMSAYTEASKKTKKKYMIEANLDKFN
                     VIEKGTVTLNVMFEEGFNIINTTFSESMENVKNKVIVVDQYGSKISEKIDNEIFKEVN
                     VIMQKVIQQQENQDVDIDSEFNGIEKSCSLKGYGDVSCITGRGVKVKDSYTKLVGLFY
                     IDTDKHTWQNGEYQIELELNFQNLMDEKSAGQDEPKEESNLGGEDYAGGKEFTAEFTA
                     YCPRKEEGGDTDCRKKKLDPSKKTCAAPMVGKYEQTYYTKEFLNKHPLLNYGDEIQVI
                     TGVSGRDGVYKVNDVGPAITIEKNGTYHIDILFGNVEEASKFGRRKGKIIIGGYSGNV
                     SDKAKIVISEAKKHLGKPYKWGGNGPSSFDCSGLMVYCFKKVNVSLPRTSNQQSKKGK
                     KVEQKNLQAGDLVFFHNPVSHVGLYIGNGEFLHAPQKGDVVKISKLSSRRDFNTARRV
                     L"
     gene            complement(14269..14691)
                     /locus_tag="KNP36_001694"
     CDS             complement(14269..14691)
                     /locus_tag="KNP36_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873572.1"
                     /translation="MEMWLRQAEDRFRFPVFPSSFSINGKAAVNSSSILKIGEIATFG
                     GVALKSISISSFFPNKDYTFCDYTGFPSPYDCVNKIEKWMKEGFILRFTITETNINME
                     VIIEGFSYEERDGTRDVYFTLDLKEYKRIKIPKVTPKQ"
     gene            complement(14691..17144)
                     /locus_tag="KNP36_001695"
     CDS             complement(14691..17144)
                     /locus_tag="KNP36_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873573.1"
                     /translation="MGNVREEGINMYLTDNYTPKMNQIISVTDNFRRATVAVSLSTNV
                     MASSIKNSIGSASNRVNSLNSSLRKVQTTASSVSSTMTKLSSSINAVSGVIGSLNGSI
                     MILAITIAMIIDYFNKLIQKKNEFNSNIMIILIFKAKSDEVEKTKNKLLGNLKKIGGK
                     VWNIVIKAKDMTKRVISSILGKLKQVEKRPYQGSINLKDMVSSAMGRILPKLMLFKNT
                     FWSGVIAIKDMASGIISKVFPKLRLFAGKVWSGAIAVKDMASGILGSIKGKISDLTNG
                     ATIGVAVKKGVDLLGQEQNQKVVLESVMKRNTGKVNQIDVDDYYGSLVRMANDTPFDP
                     EDVVAMGTKAKMISNITGGKKEKDITQAMVDVRALNMNTSSEQDVSAAFLSAAKGNME
                     SLNTLVGENYKTFDEALEGISVKQMGLAKEMSNTIPGIISGAQTSINNGLKSIVKPFD
                     DILGQGLKKIKTFIESGLGNLAGLSEKMAGKIGNVMNGKIIIGNKYDQMQSRSVKNGK
                     EFSDSTQYRISNEAEKRKMMVENKQERFENHAATMIGNAPKAIVNAGSTLLQNIDFTA
                     LIDSLLPVVNLVNNLLDSINNKSPIAQGLISIFGTIVTTAFQLIGPVVEAVSPIITRI
                     FTFLGEYAPQINNFIETLGVIWKTVWETLGPLLETGWKIIEPILGAFFNILDKVCKIV
                     KDICKWWQTMINKIKNGSITGTVLNLVEKSKKNYKDNPYAGTKAGDSGKAYSGKKGNN
                     AFGLNYVPYNDYQTRLHEGEMVLTKQEANQYRSRKNGGNINIAKLADTIVIREEADIE
                     KITSKLVASIQLAQLGGVL"
     gene            complement(17144..17311)
                     /locus_tag="KNP36_001696"
     CDS             complement(17144..17311)
                     /locus_tag="KNP36_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873574.1"
                     /translation="MYYYWKKKGIRPSLFYAMDKGELKLIEAFFALEIEEEVEKMKHG
                     YGVCPLTGGGM"
     gene            complement(17338..17784)
                     /locus_tag="KNP36_001697"
     CDS             complement(17338..17784)
                     /locus_tag="KNP36_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HBF0873575.1"
                     /translation="MSENGLSKNINIVDLLLNSDTENLERPSTIVELKRLSTIFGQEF
                     KVMCRALTISKDEEIQNTCLKIDENMKTDIDLPEMQMLTIIEGVCDLDGKLLFKNKEL
                     MDKFKAPTPKELARKLLLPGEITNLYRILQDVMGYGKNAVIEEVKN"
     gene            complement(17910..18338)
                     /locus_tag="KNP36_001698"
     CDS             complement(17910..18338)
                     /locus_tag="KNP36_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tube protein"
                     /protein_id="HBF0873576.1"
                     /translation="MANMEARNVMSGTWGELWLDGNKVAEVKKFQAKMEFTKEDIIIA
                     GQMGTDTKYIGYKGKGSITLYHVSSRMHKLIGEKIKRGSEPRFVAISKLNDPDSYGAE
                     RIAVKNIAFDDLTLADWEVGVKGEIEAPFTFTEYDFLDII"
     gene            complement(18352..19416)
                     /locus_tag="KNP36_001699"
     CDS             complement(18352..19416)
                     /locus_tag="KNP36_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail sheath subtilisin-like
                     domain-containing protein"
                     /protein_id="HBF0873577.1"
                     /translation="MAIGLPSINISFKELATTVKERSARGIIAMVLKDAKALGLNEIH
                     EKEDIPVDLSAENKEYINLALMGNVNTPNKLLVYVIEGEADIQTALDFLETKEFNYLC
                     MPKAVEADKTAIKNWIIKLRDIDKVKVKAVLGKVVGNHEGIINFTTEDVLVGEKKYSV
                     DEFTSRVAGLIAGTPLSQSVTYTKLSDVVDIPKMTKVDAESKVNKGELILIKEAGAIR
                     IARGVNSLTELTAEKGEMFQKIKIVDTLDIIHSDIRKVIIDDYIGKVTNSYDNKCLLI
                     VAIKSYLEELEKSALIESDSTVEIDFEAQKSYLKSKGVDLSYMTLQEIKEANTGSKVF
                     LKAKIKVLDAMEDIDLSIEI"
     gene            complement(19421..19864)
                     /locus_tag="KNP36_001700"
     CDS             complement(19421..19864)
                     /locus_tag="KNP36_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873578.1"
                     /translation="MLKYKEILETIIEILKKNFTESIFIDDESVQGSEGSCFFVSILS
                     VICTPVMLNTNNKDIVISIKYLPKPQSKSIRMYEVSDELNKLFNRNIKVTDRKLNITK
                     LEQSIKKEESIYVLNFTFTLNYLDSVYEEDVVYENMEEINLNLGE"
     gene            complement(20113..20553)
                     /locus_tag="KNP36_001701"
     CDS             complement(20113..20553)
                     /locus_tag="KNP36_001701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873579.1"
                     /translation="MENKKDILFKETDKRLHNYKYLDIKIKNINLDIKRCENEYSGCG
                     AMVYTEKTSNTYNISSSVENEVLKREERLRKLKMEKEDIEIEKEKIENALTCLNDIEM
                     EFFNLFYNSKTKNNMTYISMKLHLDRTSCYNLKKKMIFKLSEIL"
     gene            complement(20658..20855)
                     /locus_tag="KNP36_001702"
     CDS             complement(20658..20855)
                     /locus_tag="KNP36_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873580.1"
                     /translation="MFKNNLKYYRKCKGMTQIQLARKAGITNDYISQIERGIKNPGLL
                     MAKKISSILEQNIEEVFFIQL"
     gene            21024..21344
                     /locus_tag="KNP36_001703"
     CDS             21024..21344
                     /locus_tag="KNP36_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HBF0873581.1"
                     /translation="MFAKRLRELRKEFGLTQRELGEKVGVSQRVLGYYETENRFPDEH
                     ILNKLADVFNVSVDYLLGRTLVKENIDTVAAHRKNPHEELPEEAQEQLNDYIEFLLNK
                     YKKK"
     gene            21426..21932
                     /locus_tag="KNP36_001704"
     CDS             21426..21932
                     /locus_tag="KNP36_001704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873582.1"
                     /translation="MNNLDKLFELASQEEIIIHYTTYIAGDLEGLYINKHGIKIISLL
                     SNLKQNSKKLTSILAEELGHHFTSLGYYVSSYNDYYTKIIIDKCENKALKWACEFLIT
                     EEDIINIINSGITCVYEMADILNVDITFFQKRLEFLSLKKQSLQLGNNKYLILTNLPY
                     FYIFDPIS"
     gene            22633..23388
                     /locus_tag="KNP36_001705"
     CDS             22633..23388
                     /locus_tag="KNP36_001705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBF0873583.1"
                     /translation="MEKKVLATVGEKEITNIDIENALKSLDPYQAMQFKTEEGKKHLL
                     NDLVNQELFFLDAKEEKLDEEEIFKLEMKKIEENVLKQFAINKVLSSVNVTEDEKVKF
                     FEANKSSFSKPESATAKHILVDSDEKAKEILAQIKSEEISFEDAALKHSSCPSKDMGG
                     DLGTFGRGQMVPEFEEAVFSMAKGEVSEPVKTQFGYHIIKLEDLQESTESTFDEVKAE
                     VEKSLLYQKQNEVYGNKINALNAKYGNLVKYND"
     gene            complement(23531..23959)
                     /locus_tag="KNP36_001706"
     CDS             complement(23531..23959)
                     /locus_tag="KNP36_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HBF0873584.1"
                     /translation="MNILFFLTPKSEVAYIYEDYTIRQALEKMEYHKYSAIPIISKDG
                     KYVGTITEGDFLWTLKNDLNLDLKGLEDVPVTDINRKMDNSPVSINADIEDLVIKSLN
                     QNFIPVIDDQDTFIGIIKRRDVIGYCYEIIRGYKNLANDN"
     gene            complement(24380..24580)
                     /locus_tag="KNP36_001707"
     CDS             complement(24380..24580)
                     /locus_tag="KNP36_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBF0873585.1"
                     /translation="MKTGVVKWFNNEKGFGFISVEGEGDVFVHFSAITGDGYKTLEEG
                     QSVEFEVVDGAKGPQAANVVRL"
     gene            complement(24763..25932)
                     /locus_tag="KNP36_001708"
     CDS             complement(24763..25932)
                     /locus_tag="KNP36_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidase domain-containing protein"
                     /protein_id="HBF0873586.1"
                     /translation="MGGVALKILKNKNKYIKGIMAFVFLSLATTAGVFLINDLSMKNM
                     EEKVMESANVEGDDVKDQYKLLLENLFDYRNKAILEKNENILKGLYETDKKFGLWAYE
                     NEVKKMKYLENWSSKQGVKFKDIKTRVKIKKIKEKEKDLYGIICSVSTEYKYSYENQK
                     DKENAFRIGTYHYLNVKIIDNQYVITKEWYTDPFADSLNLENIKSDDIRNYIGQQDGV
                     ELQLTDEQKKAIDYAHKYCGAAADEEHGMKFNPNYRDYNPEGGDCANFASQIMFESGR
                     FKKNSIWNYSERAGTKAWVNAQAFKNYALYSGRGSLIAKGSYEEVYKEAYNLRPGDFV
                     GYEKKGRITHVSTVTGLDSRGYPLVTCHNTDRMLVPWDLGWSDKSIRFHIIKINY"
     gene            26168..26989
                     /locus_tag="KNP36_001709"
     CDS             26168..26989
                     /locus_tag="KNP36_001709"
                     /EC_number="2.7.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine kinase"
                     /protein_id="HBF0873587.1"
                     /translation="MQKKVAAINDLSGIGKCSLSVAIPILSALKVQCCPFPTAILSSQ
                     TGYPEFTFLDFTDEMVKYSNVWKNLKVNFDSIYSGFLGSKHQIEIVANFINDYPNAFI
                     VVDPVMGDNGVMYPIFTEEMRQEIKELVKHSDLTTPNLTEACFLTGNDYTKSDYNRDE
                     LIYIAKSVSDLGPSKVVITGILEDDNILNLAYNRDNDHVFFTSVKYNNCSYSGTGDIF
                     TSILCGMLVNKHDLGVAVNTATDFIYKTINYTSQFDTDRNDGVMFENFLSDLTNI"
     gene            complement(27065..28453)
                     /locus_tag="KNP36_001710"
     CDS             complement(27065..28453)
                     /locus_tag="KNP36_001710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase"
                     /protein_id="HBF0873588.1"
                     /translation="MLGGKKSNNKKVEKLRTIFIKYLSLFFIMTISIVLLLMLSFSVL
                     LSSGVILPANYAEKQFNKYKEQIISSEKVTEDIIPSIYEYGVYTLDGNLISGTFNKKE
                     SKEVWNLMRDIEERHAYSESYIKFFKKDEVFIIKYKIVSEYSSPILRAYLPKPETLGM
                     IIFSIIFFIEIVILSKVFGKKFNIEMELLKNTTEKIEQQDLDFVVESSKIYEINNVLF
                     SMDKMKLALKDSLEKQWMLEENRKEQISALAHDIKTPLTIIHGNTDLLIEINENPELL
                     EYMEYISKGVTQIEKYINTLIDISKTENGYILNKEAISMSEFIKDVLVQIEALASTKN
                     LDVEFYKQDNLPKNITIDRELLFRAIMNIISNAIDYSPSQSKLYISVSVHNKYLKFVV
                     TDCGSGFSKADLSKATEQFYTGDLSRNSKSHYGMGLYIVNNIVQKHNGTLCIENSVKT
                     GGAMVTIEIPIV"
     gene            complement(28588..29346)
                     /locus_tag="KNP36_001711"
     CDS             complement(28588..29346)
                     /locus_tag="KNP36_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="HBF0873589.1"
                     /translation="MRQLIRIFCSDLIKLKRNFIILMHICIALMGMGLFLWYYKVSGA
                     DNILKIVAYLQVIAIAFPLLSSVVCSMFVEQEYYAGNYKHMLTTSNPKYLTLISKYII
                     LVCLGFVATLVSVLGFKFGISKAYFTSSFYMISILILIGCNLFEYILHLFLSLRFGKG
                     TSIGVGIVEMLLSALLLTGLGSGIWQYFPCAWGVRFITIWSSFSSSKTVEYIKVESIK
                     AYQSTGLICGFVTILAFVILCIWFSKWEGKKSEE"
     gene            complement(29348..30064)
                     /locus_tag="KNP36_001712"
     CDS             complement(29348..30064)
                     /locus_tag="KNP36_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="HBF0873590.1"
                     /translation="MERFIRVEFQKMKGTFGMKLIWIVPVFCILLCGLGGGQNAAFNW
                     WYTTFLPGALTLISSLIVLKDEKSKYRGILPLPIEMKDVWTGKMIYCIICCFIASIIS
                     AIGVVFVGIIYKETISIGQNIIASILIILLFMWQIPLCMFLASKFGMFVTVLTNMFFT
                     IVGVAVFSTTEMWYMFPYSIPSRLMAVVLHILPNGLPVPEGSEFLNNAVILPGVLISI
                     VLFVLFALATRVWFNNREVK"
     gene            complement(30066..30773)
                     /locus_tag="KNP36_001713"
     CDS             complement(30066..30773)
                     /locus_tag="KNP36_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="HBF0873591.1"
                     /translation="MSNYILQVKGVSKKFKEQMAVDNISLAIKSNSIYGLLGPNGAGK
                     STLLKMITGILNPTSGKIMFEGHRWTRKDLSNIGSLIESPAIYENLTARENLKVHTTL
                     LGLPDSRIEEVLETVDLRDTFKKRSGQFSLGMKQRLGIAIALLNHPKLLILDEPTNGL
                     DPIGIEELRELIRSFPKQGITVILSSHILSEVEQVVDEIGIISNGVMGYQGEVSKEQN
                     LEELFMKVVAENRKRGQ"
     gene            complement(30889..31425)
                     /locus_tag="KNP36_001714"
     CDS             complement(30889..31425)
                     /locus_tag="KNP36_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0873592.1"
                     /translation="MNKIAVSFLIIATTLLSTACMDYSISAVELVDSKESAVVKKDED
                     AKEETTSKMINSKKTTKIPIEIISKDEKIVKYLQIDEESSLKDKLRLILDTLSNEYFN
                     GLDMEVEVKEKDNLVKINLIEPDKKSRVSWKDDYLNEQNIIYTINNIIKNVIQEEDNS
                     IWIEEVEIYYNGKLIELR"
     gene            complement(31527..32597)
                     /locus_tag="KNP36_001715"
     CDS             complement(31527..32597)
                     /locus_tag="KNP36_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 family beta strand repeat protein"
                     /protein_id="HBF0873593.1"
                     /translation="MNKKLAIFAAVLLVIGIIGTTWSGILVMPSLINFGLEKEAELNK
                     ENKLYQEKVNIDKLDIAVDNINVMIRKSSNEDVRVTTRGNNEFYKYSVTLQDKTLVVK
                     GERKSENKIKKIRSFDHLLNTSINSMFSRDYREIRIYVPNNVDINASSISSYLFISDD
                     VDSNNITYKTSSGGFSRAITENKVNRLENLNLISNSNLHLSTKSILGVKNVNIESESL
                     DISSENGDVFINNIEEYIPENVNIKEKIGRNSNYESEFYLYSDMPIAKFLDIEVPNSK
                     VRLDIPVNKYKFNCDIKSKEAIEEFNNDEEYDNDSYDYEHNEEHSNKYRNTREIKGLL
                     NKNLSNLEKEYTIKINSNSLEL"
     gene            complement(32590..33648)
                     /locus_tag="KNP36_001716"
     CDS             complement(32590..33648)
                     /locus_tag="KNP36_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HBF0873594.1"
                     /translation="MNLNKTEFLEILKDYLKKDFSESEVNDILRDYEEYFVDGLIEGK
                     SDMEIIASLGSPKSIAKELILQTKEKNIEEEKIINTDVLNDKFSKFKSDMKKGYSILK
                     DEAKEKYSKSKENIDGKIMNTDILNGKFSRFKSNVKKDYSILKDEAKEKYNKSKENIN
                     DKLTPSIEEGVGGLSRQVIKGLLVVLSLFLIVPAFAFVCAIVSATIALVCSLIAFVIL
                     IPFVIKFIAMVPDVMMFCIFATIAFVGLEILAWQILLFAIKLGKQLLNNYIHWIKRKN
                     IYIKANEKMEKRKKATLNDEDLNKDINENSYNNDYYNREEESIKETDEYNDDSINFEA
                     IYKDLEDIENKKGEDKHE"
     gene            complement(33635..33967)
                     /locus_tag="KNP36_001717"
     CDS             complement(33635..33967)
                     /locus_tag="KNP36_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBF0873595.1"
                     /translation="MNTQFRKGVLEICVLALISKKDMYGYEIVHNISKVIDVNEGTIY
                     PILRRLTKDLYFETYILESNEGPARKYYRITSLGKENLSNLMEEWREFVKAVEILISE
                     DEGGNELE"
     gene            34166..35287
                     /locus_tag="KNP36_001718"
     CDS             34166..35287
                     /locus_tag="KNP36_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactosyldiacylglycerol synthase"
                     /protein_id="HBF0873596.1"
                     /translation="MKDDKTILILTAQFGAGHISAAKAVKECIIEKYSNYNVVIQNFI
                     NASIPMMNKPMVKLYENNTKYTPGLYNYYYYFKKSFDSRHDLSHKLYTPKLSEYIADI
                     NPDLIISTFPLAAACVNNFKIKNPDINIPTLTVITDVVDSMEWVFENTDLYFVPSPEI
                     KNRFFQKGINPDSIKVTGVPVDKRFQIESKELCCDKYRLLLLGGGRGLFDIDEDFMHW
                     IDEFIEEHSNSIEITIVTGKNKKLYDNLTHKKPLKNIKVLGFVNDMYNLIRECDLMLT
                     KPGGATIFEAIQSQTPVLVKMPKVGQEIENAKFIIDKGLGMIYSDDLDLKNIFYKLVS
                     NEFDSIINFMKKNLKEFKTVIHPEKIADYISELIDNHYS"
     gene            complement(35415..37313)
                     /locus_tag="KNP36_001719"
     CDS             complement(35415..37313)
                     /locus_tag="KNP36_001719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HBF0873597.1"
                     /translation="MDSLLYVIEKDKHTNEELREILKSNKNIRFVSLMGVDLGGNATD
                     EKIPVELFLEDIDKFLESAIQTDGSSVELYNIATLNNAKVDLMPDKSCHWYVDYNMEY
                     IDEEVGLPVGTLKIPAFLIHDNKKVCSRGVLQKADKYFKKSMYEIFREYPHVINNIGI
                     DSVDDIEEIMLTAATELEFWVNTPEDKADLEKLYVSQSLKEQYWKRTHGIIRTCLEKS
                     LIILQKLGVNPEMAHKEVGGIQSSISIDGRTNHAMEQLEVSWKFSTPLQAADNELLVR
                     DVIEDVFTSHGLEVTFKAKPIHGVAGSGGHTHVGVSAKLKDGSIKNLFAPKDLKEDYL
                     SELGYGALMGLLYNYEVLNPIVTASNDGFNRLVPGFEAPVCIVTSLGHSYEIPSRNRS
                     VLVGLIRDMKNPKTVRFELRSPSPLSNTYLVIAGCYQTMLDGIKAAAKSGLSTKELEK
                     ELSKNVGEESFYLEKDRAYRDENDVFEHYSLEERNARFGIPPATVYENMKNLEIYASK
                     LKSLKQGDVFTDSIIESFKIGAIDKWQKKLKTRIIEAGIQKIRSIVKIHTKENMDALD
                     EVVWNSISDLKFNIMKDTLTRESLFTRVREAIENKDYQTASDLQIELKRSMEEIQQLY
                     MQYKKNIY"
BASE COUNT        12171 a         6303 c         4035 g        14992 t
ORIGIN      
        1 aaatgtcatt tagacattac tcataaaaag aaaggagtgt attttgtgga tactttagga
       61 aaaagaattg cttatttgag aaactccaaa aaacttactc agcgcaaact tatggatatt
      121 ttaaaatttg aaaacttagg caagtatgaa acaggagata gaaaacctaa ttgtgatata
      181 ctaatgtcaa tagctgatta ttttaatgtt acgactgact ggcttctcta tggtaaagag
      241 aaggtaaatg tcaatagtag tgtaaaagaa gataaagaag attacttaca tgttactaat
      301 gatgaaatga cgatattaaa tctatacaga caactaaacg aacgtgataa aataaaaata
      361 gaaggaatac ttgaacttaa gatatctgaa tataaagact taaaaaagca ttcctctaat
      421 aataatgaag ataaaatggt ttaaacatac ataatttgat acgattttac atcatctatt
      481 aaccttcttt ttttgtagta tattactaaa atatggatat tggattattt aaaaacaagt
      541 atagtctaat ttcaagcaca tttataatat ttagattatc ttatccatat tttagtttaa
      601 gtactttgaa aaatataata catctctatg tataacttat attcctaaga aatgcattac
      661 tcatgttttt aattcttcca acatctttct atacacaatt gtacatcctt cataattccc
      721 ctctttaaga aggattgaac atgtactaga atatttagtt aaagtattta atctttccat
      781 atttaagctt tttatattac tgagtgctgt aataaaatca tcaattgctc tacaacactc
      841 tataacccca tctgaatcca atttacacac aagaatattc acctacttta tatactattt
      901 attaatcatc ttctgaatat tctatattaa gtaattgata aattgatgat ttatattttt
      961 tacctgttct tcttccattt aaaatagctg acaaatagtt ttcattaaca cctattttct
     1021 tcgctaattc cctttgagtc atatttaatt caataagtct ttgcttgact tgcactccca
     1081 aaaaaggtat ccattttttt cgagcatcca tttatcaact tcctttctaa gtgatttata
     1141 tttactttta tattatttta gcttacacac cccctctatt tagtatatat ttttaatatg
     1201 tacacatatt aagtatataa atttatttaa tactaaataa gattttttga ttactttgtg
     1261 ctaaaattag gatgtaaatt cgtatcatta agttaattat aaagtcattt tgaccttaag
     1321 tcaatgcttt ttatgtcatt ttgaccttaa atttgaaact atttacatct taaaaagtct
     1381 ttttgacatt aattgaatgg agagtgttta tggatacttt aggagaaaga attgtttatt
     1441 tgagaaaagc aaaaaacctt aaacaatatg aactagaaga aatgttgggc tgtgacaact
     1501 taagtaaatt tgagagaaac attagaaaac caaattatga aatattaaaa tctatagctg
     1561 agatatttaa tgtttcagta gactggctat taaatggaga taatctatca cataaatcag
     1621 atttaatttg cgattcctcc tcaaactatc cacttaatag cataaactct aatgaaataa
     1681 agcttttaaa caattttaga aagttaaatg attatgataa agccaaaata gaaggtatga
     1741 ttgaattaaa acttcatgaa tatgaaaaag agaaggattt aggaaaaatt gagtataaca
     1801 aaaataaaga tgagaaaata gataaataat ttttatgttg cttttgatac gattttacat
     1861 catttctttg ttctaatatt tttatttcat ttattttctt ttttataatt ttatgataaa
     1921 ataattagta tattttgctt tacttgaatg taattattta tacaaaagtc aaacataata
     1981 taaatgtagt aaatttttag tttcaagtaa tatctcgtta ttataactaa atatttatta
     2041 aaattaggag gataaaatgg gcttaagaga caaattcgcg caatcatttg ctagatcaaa
     2101 aactatgagt ggccctgaga aaaaggctaa tgaaataatg ggtaaattgc ttcttaagaa
     2161 agctatatta cctatcgttt taatgttcgt gataataatc gctggagcta tgcttaaaat
     2221 caattcttgg gttacacttg gcataaattt agttattgct gttggtgctt tcttctacat
     2281 aagaaattct agtaaaaagt atcagaactt taaaccttat gttggcaatt tgattagttt
     2341 agagaaaaaa ggtaaaaaag agtacgttgc tattataaaa caaggtaagt taccagttaa
     2401 gttacaaata gcttatggtg gtgaagacct tgaacatgtt aagaaaaatc aaatggttca
     2461 aataagttat aatccagatg ctaaaatagc tattttggtt aatagacaat aatttaataa
     2521 aaaaaaggag ttgtcttaaa attgattttt tctaatcaaa tttaagctca actccttttt
     2581 taatttttat atattatttt tatatattat ttttattact ttttttaatt aatattttta
     2641 aatatcaaat ccttctcaat aaaatagggt actatctaca atactacttt atcttttcct
     2701 aacaatatat aatctggtgc tactctttca tgttatacac cgttttgtaa catacctttt
     2761 ataccagtaa catcttcctt aatttcctct acatctgttt tcattatacc catttgaaca
     2821 agtatatttt tgtttatttc ttgttgttgt gtagataatt ctataaaatt ttctacagtt
     2881 tttttataca tgtctctatc ttcttttttc tcctgcatag tatttttaaa taatagagca
     2941 catagtatac ctattgcccc tagactactc aattcggtta ttaatttatc cattatagcc
     3001 tcctattgtc taaatttttt atacttatag ctttaatttt tgttatattc ttacatcatg
     3061 caatattata ttttcaggat tatcaattta atcttctgta ctttaaattg taggtgcaat
     3121 ttatagattg aataaataat aaatatatat acaatttcta atataacaaa aaataagtac
     3181 aaggcttact tattaaagtt aagaccttgt actttacata aaaaaaataa ctaatacata
     3241 gttattctaa atttactatt caactggtat ttctaattct ttgcatctaa ttctaacttg
     3301 ctctctaatt actgctggta cttcttctat tgtttttttg cctcttaaaa ttaaagctac
     3361 atatacttct accattccac tctcacctcc agattttctt acactaaaag agcttatatt
     3421 acttgcttca ttgacagaac tttgatttaa caacatctca tatatttctg catttgctat
     3481 aaaattattt gttatatcat catcttgctt tacttgacct atacttatgt ctgaaatgtc
     3541 tttatactgc atttctactt ttctaccttg tttgatttgt tctattttat ttttatcgaa
     3601 tttaaacaat tttcacacct ccattttaag cttgtggctc gttgctttca gcatcatatc
     3661 taaaaatcat agatggacgt tttatagctg tccatttatc tcctttttct actatgattt
     3721 taggctgagc actttttatg ttggcttctt ctaattcata gatttcttgg taacttgagt
     3781 ctgatttttt gatttcaact agtttcatgt ctttgaataa gtcagattta tttattttta
     3841 cttgaacttt agttttattt attaattgat atataggatt gttttccatc atgtcatcct
     3901 ttaatccctc atttaatgtt actattaaat cagtgttatt ttcagtaatg tttatgattg
     3961 aatatacttt attgtttatc attaaaatag aatccttttt tactttaagc cctgtttctg
     4021 atttaaatat aaacatactt gaatataaat cgcctgtagg actactggct ttaatcagta
     4081 tcttattttc tcctaatact attttatttt gtggtatctc aaatataatg ctatttattt
     4141 ccaaattagt cttagtagat attaattcat catttataaa catttcaagt ttttctataa
     4201 cattattagg gtcttgtact acaactctca cttgagatat tgatttttca actatttcta
     4261 tagatgcttt acttgtatct acttttgtta tcatgtatat tgtatcatct gaaagctcta
     4321 tatctaaaat atcatttaga tgttcaggaa ttggtatttt agtaaattca tataaatcag
     4381 taattgatat agatatttta tacatagatt tatttttacc agttatccat agactattat
     4441 catttttaat tactagtatg tggtcatcat tatgtgactt aatttcttta acattagtta
     4501 atactttagt aaaagttctt attatcttat ctttttcact ttctcctagt ccaaataatc
     4561 catttgtatt gtacccttga gcgtacaact ctccctcatt agttaaaaca agtgtcattg
     4621 agttatatat acttatatct ttaacagaag gtaatccagt aaccttttgt aactctctta
     4681 catcattatt gtggccaact cccaattggt actcagtatt ctttccatat gaccatagag
     4741 tattatctgt cttaataata taggagtagt tatctccaca agcaactttt ttgacatctg
     4801 atatatttac ttcagtaaga gttaataatt ctatatcttc aagggtttga ttaatttctt
     4861 tatatgaatt acttcctatt ccatataact tgccatcctt agcaacagcc aatgaatgtg
     4921 tttttgatat atcaatatca gatacctcaa atggcaatat tattgaagta tacttaaaat
     4981 tatctttaaa tatgttttta taatttatat acttattatt tgtttttata tacttatcat
     5041 taaacattac tagcttttca tttttcttat taaaaactat tttatctgat gtgttatctg
     5101 ttttaaaata tgaatgtagg gaaccttcaa gagcttcatt tttatcatta tcatatctat
     5161 ggtgaatacc taaatgatta tatctattat ctcctgttga agaataaaat tttccatata
     5221 tatctttaat aaatatagta ttgtaactag aaaatacagt atcaacatct ttctttatag
     5281 atactttata atatggaact gacatatccc tataagattc atcagatata ccataagtat
     5341 ctctacctga tgatatcaaa ttgttattat tatctatata aagtgtatta ttagctgtta
     5401 caaaaacatc tttaacatct tccacactat ttgtattatt attatttgct atacttccat
     5461 atccactaag acctccaaca aatagtttat tgtcatttgt taaaatggct gaagtatatc
     5521 cattaactac tatttttttt gcatttataa tattattaat tactcgtata ccctttatat
     5581 cattagtttc tgttgaaaag aataccctct cttttttccc tgtagtataa ataacattgt
     5641 catttgttat aaaaaatgta gcttcacttc ctgctgttac aacagatttt acattctcaa
     5701 tatttatttt tgtaaatgta cttatacttc cttcagtaaa cccaaaatat ccatttacaa
     5761 atccacatac ataacatgta ttatcatttt taacaattat tgatacatca ttacatatat
     5821 acacatctct aactccattt ataggtatac gtgtaaatat attcctactt gtagtatcac
     5881 ccaatcctaa ctgtcctttt ccattattac ctgctccata taaaagacca tcattagtta
     5941 ataatagaga tgtgtttcca tatacagcta catattttac attttcaaca tttattttag
     6001 taaatacatt tctatttaca ttatctccta ttcctaactg accagaatta tttaaaccaa
     6061 cagcataaca ggtattatca ttttttatcg caaatacatg tttactattg tcagtaaatc
     6121 tatttacatt tatagatttt atattatcaa tatttatttt agtaaatacc tttctattta
     6181 tctcatctcc cactcctaat tgacctacat catttaaacc aacactgtaa agcatattat
     6241 tattagttaa taaatatgta gacttcgaat ggctatatat ttcttgtata ttagaagata
     6301 tttcactact gctattcttt ttattgtaat ttatcttatt atttaaattt aaactactat
     6361 taactgatat accatgcgta cccttagagt tatatccaca tataaataag ctcttatcag
     6421 ttaatattgc aaatctagtt ttatctctac ttaaatcata aggaggtata aatatatttt
     6481 ttatattttt cattaccttt ttataattag tggcattata tccatcttgt gtatctgaaa
     6541 catctagttc ttttgcactt tcagatatat tcccaaaacc atataacgtg ttagaagata
     6601 aatacaatag agctttatat aaaaatatgg ctttatcaga ggtaatagga cctgaattta
     6661 tattagatgc tgcaatatta ttagatgatt gattgttaag ataattcctt ccatattgat
     6721 gtatataaga tgaacctcca gaaataagta aattatctgg atttacattt tttaaattac
     6781 ttgttgattc tccataatac aaataggcaa aatttgtaga atatgatgat tgtgtacacc
     6841 ttgtgggata atagttatat atgtaattac taatatatcc agcatgtgta attccttgtt
     6901 gttgaactct ataagtagaa tcacttggct ttgtccataa agtaccatgg tatccagtta
     6961 aaaaagaacc ataatttgta cataatatag ccatatattc atatataata atattattaa
     7021 ttttagtaat atcatttgta caagaatttg tactataact tgctcctgaa ggatttacat
     7081 aaaaccagtt atttattaat gttaaattta tattgactcc atcattagga ttaacaccca
     7141 ataaatagtt tgtatttata ccagttgcat ataccttttt ttcgtcagcc acaataaatg
     7201 ttgcattata tgaactatat gcatctgtta cattgctaac accaatctca gtatattgac
     7261 ttgctgattt attactaagt ccattaacat aacttgaact ctttccagaa gtatatattt
     7321 gcttattatt agttacaatt aatgaaaacc agtttgataa atcagtattt ataacaactt
     7381 tttttacatt atctatagat attttcttaa atatatctga attagaagga agaacacctg
     7441 ctattgagtt actatttggc ccagaataat aacaagtgtc atcattttta atgtagaata
     7501 ttcctccaga aatatttttt gatgctacta tagactttac attagagata cttaattttg
     7561 tcaactcatt taattgactt ggtaagtcag aacccattcc tttgtatcta ttatttccta
     7621 gaccatatac atctccattc cctaaaataa ccagagtaca ataaggacta aaaacgacat
     7681 ctcttacaga atgtatatct agtggaagtt caatatcctt tatttccatt tcttctttta
     7741 ataaagttaa tttatcctca gatttaatta aatttatata attactataa ctatattttt
     7801 cactatccat tttcttaaat tctacaatgt gcatatcatc aaaaaacgaa cctaattgtc
     7861 cataagtatt atctcctgta caatatgaat cattatttga atcaattagt atgctatgtg
     7921 ataaaccaat gaaaatattc ttagctacaa tattttttaa atctataaat gaattatcta
     7981 tattctcaga gtaatttgct atacctaact gatatatatc attatttcca gcaaccttca
     8041 aaataccttt attatctata agcatagtat taccattacc acatgcaata gtttttatat
     8101 ttacttcttc tatcttagta aatagtgatg attgaagtgc atttccaaaa catttttcct
     8161 ttccacaacc atatatatca ttattatacg tcattaacac agtgtgttca gaaccacaag
     8221 ctatagtctt aacatcatta atagaaacta agctaaataa atctctatta ttcttatctc
     8281 ctaaacctag ttgaccttga ttattaaaac cagtagaata acatttattg tcattcttta
     8341 ttataaaagc tgatttatta tatgagaata cagcctttac attatcaaca tctactttta
     8401 taaatgtatt tacatttgca gatgctccat tagttcctag acctaattga ccatacaaat
     8461 tatttccagc aacatataaa gttccatcat tgtataaaag atatgttgat tgaagtccac
     8521 atgcaatatc ctttacgcct tttatttctg gaaccttctc aaatgtggaa actgtttttc
     8581 ctactttttc taatcccaat cccatttgac catctgtatt tatacctgcg acaagtaatt
     8641 ctccatctga agtaagtata actgcatgag attctccaca tgcaactttt ttaatattag
     8701 tagatatatt tggtattttc gtaaataatt ttcttgttgt attgtcttct cccaatccaa
     8761 gttgaaagtt actattatct ccacatccat acaagatatt attatttttt agaccaaatg
     8821 tatagttaca acatccagta aaaaaattaa taaagtcata attatcatac ccttcatcaa
     8881 attcatcaac taccatattt ttatcgccaa agaaattacc tctttgaagt agtttagttc
     8941 ttttcattat aaaaacctcc taattatctt atttcatacg aatatttatt taaagttata
     9001 tctgtctggc caattgaata tgccctatta gattttgttt caacaaagtt attatccatt
     9061 tcatgtatat atctaactct atttgcatta aatggtagaa ccacattctt aaatgtaaca
     9121 ctaccaagtt ctccagttat acactttcta tttaaatcta acttaaggcc ttctatagct
     9181 attatgtttt tagcattagt taaggtatca taccaatatc cagcttcatc tacatctatt
     9241 tctgactcta attctaagta tattaaaata tctaatactt tttcagataa tttattgtaa
     9301 ctatttttta atacagatag ttcagtttgt atttgacctc ctattacatc atcaatagat
     9361 atatttttaa ttttttctac tacctcattt atagctcctg ataagttttt agcttctgta
     9421 gataagagtt cttctccaat ttttactttt atttctttta tatttttatc aaccttatca
     9481 tctaaatctt gaatatcctt ttgagttaca aaaaccaacg tcgggtctac ttctaatgta
     9541 acatttgaag tattggacaa ttgtaaaatc atttttacaa ccaaatcttt aatactgcca
     9601 tcttcagcac gtggcttata cgtctctgga tacttaccta tagctattat attattctca
     9661 ttatccagaa cagcagcttc tcttatcata aatccaccaa ctgttcctgg taaaatagtc
     9721 tctataacta tccaattagg atttttttca tcaattctta gagaatttat atttccttcc
     9781 caaactacat tctttaaagc agtttgttcc tctgttggct cataatattc tccattacta
     9841 tctccaactt gaaacttggt taatccaaca agctctccta gtgcagttgc atttgctatt
     9901 ttttctctac caattttggt taatattata taaaattttt cttccaatta taccacctcc
     9961 gatttaggat aaactactac attttctacg cctgtatcat ttgcaatagc tatattaatc
    10021 ttacaattat tttcaatgca tttaatgctt aaaggataaa cctttatttc ttctctactt
    10081 aacattccag ctccacagtt tacaacagcg ctacatttta taattggttc aaagtatgga
    10141 tgaactttta cttcttcact acataccata cctccaccac aatagaccat acttttatct
    10201 agtattattg gttctaaata gtgtaataag tgagcaggtt ttactctttc aatcatatcg
    10261 ctacaatcta aaagagtttt atagtcacaa ttatttgcta taaaactcaa tacgaatgta
    10321 aattcatcac tataaacttt tatatctgtt tctgattttg tatatgcctc acatatactt
    10381 tttataactt caatagtact agtacctctg cttctcattt tagcttttat attgctacgt
    10441 cttgtgtcaa aatcaagttc ttttttttca atgcagagta tgtcttccca catatctaat
    10501 ccccatgttg cagtgtcaac aaataattgg ttaaaggtat catcaatatc ttctttaaga
    10561 atatttaatt ctgtatcgta tgcaccttgt atctcctcta caatgtaatt tctatcaaat
    10621 gatggtagtt tatcaattag cttcattgat tttccacctc actaaaatta acagttgtta
    10681 cactaggtat tttatcttca ttaatagtta tattatctgt acttccattt ataagtaggt
    10741 tacttaaatc gtgtacacca gtagtattta taagtattcc cattactttt gtatagatta
    10801 tctctcctct aatatctcta aagtatgtat ttatactttc taggaaagat tcttttacat
    10861 tgtctaatgt atatccatct tctaatttca ttactgcact tatatttatt tctattggta
    10921 atggtgtcac aactgttata gttggtccaa taggcttctc ttcatctata tgttgctgac
    10981 acctttcaat tgtttctgta tcaacagctt gattattttt cccaaatatc aagaccttaa
    11041 ctgttcccgg accatcccat cttggataaa ccttaacatt atagactcca tctacttcca
    11101 aagcccattc ttcatagtga gctttatttc cacttgtagc ttgatttctt tggattttat
    11161 aaaatctttc ttttagttct tcatctgtct ctatatctgt accaccttca aaacttcttg
    11221 tgttagtaat ctttgttact ccagatatat tatcaactag tttaaattca caatttgtag
    11281 gtaaattata tttcttacca acttccagag cttgaactgg gctattgtca ccttcttcac
    11341 taccaatagt tacatctttt attactacaa atagtaaatc tctatatgat attattgtgc
    11401 cattatttat tacagttcct ttctctccaa taaattcaac ttctccattt gactctgtac
    11461 ctaactttct atatacacca aattcattga ctcttttatc gagaaactgg ttatatgtgt
    11521 cttgtataaa agccatttta tgtatctttg aaagttctag atatatcttt gaaagttcta
    11581 gattatttcc agataccatg ttgtttagaa aagaaccttc tcctttataa atatcaagat
    11641 taatattttc aagagttcta ttttttatta cttcatatgt ctggtcacta tacatttatt
    11701 tccacctccc catagatagt ggatactttt acatttgcac tcaatacgtc tctgttaaag
    11761 ttagcacttt ttacgtttac ttctaatata tatggattta ttagaagggc ctcttttatg
    11821 aatctactag cttcactttc tgtaagacct tttgtatatt tttgtcctat tagttctgaa
    11881 agctctgtcc catattctaa agagtatatc tcatgttcat atctatttgt ctttatacac
    11941 ttgtatatcc aaacttttaa ggcttctttt ttttcaatta ttttaaagtc acctttttct
    12001 aaaataggtt catctttttc aaaatcccat gccacttcac gaaagattgg caattcttct
    12061 gttttaggta agatataatc ctctgggaca cctataaaag gaaatattgt actcattata
    12121 agctcaccaa cttacttaca acagcaaatt tttcgcctat tctaaacatt attaccatat
    12181 ccccagattc aaaattatct ataaaaggat tttttacttc atgctggtgt tcttgatttg
    12241 tttctgtgtc aaatgtttct agctgtctat caatcatcca actatctatc aaaatatctt
    12301 ctttttctaa tatgatgtta tttgtctcta tttttaaatc tggtaattta cttttaattt
    12361 ttccaataaa aaaagaaggt tgattatgat actttccttc ttctcttatt attcctataa
    12421 attcatttat tggattagcc attatatcac catcctttta taatactctc ctagctgtat
    12481 taaaatctct tctactactt aacttactta ttttaactac atcacctttt tgtggagcat
    12541 gtaaaaattc tccattacct atatataatc caacatggct gactggatta tgaaaaaata
    12601 ctaaatctcc tgcttgaaga tttttttgtt ctactttctt gcctttttta gattgttgat
    12661 ttgacgttct tggcaaacta acattaactt ttttaaaaca atagaccatt aaaccagaac
    12721 agtcaaaact acttggtcca tttccacccc atttataagg tttacctaga tgtttttttg
    12781 cttctgatat tactatttta gctttatcag atacattacc agaataacca ccaataataa
    12841 tttttccttt tcttcttcca aatttactag cttcttcaac atttccaaat aaaatatcta
    12901 tatggtatgt tccattcttt tctatagtta ttgcaggtcc tacgtcattt actttataga
    12961 ctccatcacg accagaaact cctgtaatta cctgtatttc atctccatag tttaataaag
    13021 gatgtttatt taaaaactct tttgtataat aagtttgttc atatttacca accataggag
    13081 cagcgcaagt ttttttagat gggtcaagtt ttttctttct acaatctgta tctccacctt
    13141 cttcttttct aggacagtaa gctgtaaatt ctgctgtaaa ctcttttcct cctgcataat
    13201 cttctccccc taagttactt tcttccttag gttcatcctg tcctgctgac ttttcatcca
    13261 taagattttg aaaattaagt tcaagctcaa tttgatattc tccattttgc caagtatgtt
    13321 tgtctgtatc tatataaaat agtcctacaa gctttgtata agaatcttta acttttactc
    13381 ctctaccagt tatacaactt acatctccat aacctttaag agaacagctt ttttctatcc
    13441 cattaaactc gctatcaata tctacatctt gattttcttg ttgctgaatt actttttgca
    13501 ttattacatt tacttcctta aaaatttcat tatctatttt ttcgctaatc ttgcttccat
    13561 actggtctac cactattact ttatttttta cattttccat gctctccgaa aaggtggtat
    13621 ttataatatt aaatccctct tcaaacataa catttaatgt aacagttcct ttttcaataa
    13681 cattaaactt atctaaattg gcctctatca tatacttttt ctttgtcttt ttacttgctt
    13741 ctgtatatgc actcattatt gtgtcataac catttactcc tataaacatc tttgtatact
    13801 tgacattggt ctttgctatt gttccaactg aaagcctatt ttcagcaaat acttgctttg
    13861 ctatgtcttc aactaactta tctttaaaat tgtatgacac ttcactttgt gtaagtaaaa
    13921 atcccatatc tttagataca aaactaattt cattactgct tgaatcttta gacctattaa
    13981 ttatcattcc tctaaagagt tctttctcat ctacatagaa acagactgta ctagctattg
    14041 gtatatctat ttgttggaaa tttacatcaa atgatgattg tattattgaa aactctagtg
    14101 tccttgatgg agatttataa tcacctgacc atgatacctt gtctactatg tcagttatgt
    14161 catatatact tccgtttttt atgtgtaccc aaatcttaat aataaaaaat cacctgcctt
    14221 ttcatttaat tctataagca gttatttata acttattatc tataatagtt attgttttgg
    14281 agttactttt ggtatcttta ttcttttata ctcttttaaa tctaatgtaa aatatacatc
    14341 tcgagtccca tctctttctt cataactaaa cccttcaatt atgacttcca tatttatatt
    14401 tgtttccgta attgtaaatc ttaatataaa accttccttc atccattttt ctatcttatt
    14461 tacacaatca tatggtgatg gaaaacctgt atagtcacag aaagtatagt ctttatttgg
    14521 aaaaaaactt gatattgaaa tgcttttaag agctacacca ccaaaagttg ctatttcacc
    14581 tattttgagt atactagaag agtttacagc agcttttcca ttaatactaa aggaagatgg
    14641 aaatactgga aatctaaatc tatcttcagc ttgtctaagc cacatttcca ttataagaca
    14701 ccccctaact gtgccaattg gatacttgca actaattttg atgttatctt ttctatatca
    14761 gcttcttctc taatcactat tgtatcagct aacttagcta tgtttatatt tccaccattt
    14821 tttctgcttc tatattgatt tgcttcttgt ttagttaaaa ccatttcacc ttcatggagt
    14881 ctggtttgat agtcattata aggaacatag ttcaatccaa atgcattatt acctttctta
    14941 cctgaataag ctttaccaga atcaccagcc tttgttccag catatggatt atctttgtaa
    15001 ttttttttac tcttttccac tagatttaaa actgttcctg tgatgcttcc attttttatc
    15061 ttattaatca tagtttgcca ccacttgcat atatctttaa ctattttaca tactttatct
    15121 aatatgttaa aaaaagctcc caatattggc tctataattt tccatccagt ttccaacaga
    15181 ggtcctaagg tctcccatac agttttccaa ataacaccca gtgtctctat aaaattgttt
    15241 atttgaggtg catattcacc taaaaaagta aaaattcttg tgataatagg actaacagct
    15301 tcaactacag gtccgattag ttggaatgct gtagttacta ttgtaccaaa tatacttatt
    15361 aatccttgtg caattggtga tttattgttt atactatcta gtaaattatt tactaagttt
    15421 actactggaa gtaatgaatc tattaatgct gtaaaatcga tattttgtaa tagtgtactt
    15481 cctgcgttaa caattgcttt tggtgcattc cctatcattg ttgctgcatg attttcaaaa
    15541 cgttcttgct tattttcaac catcatttta cgcttttcag cctcattaga aattcgatat
    15601 tgagtagaat cagaaaactc ttttccattt tttacacttc tagattgcat ctggtcatat
    15661 ttgttgccaa taattatctt accattcatt acattgccta ttttaccagc cattttttca
    15721 gataagccag ctaaattgcc taatccactt tctataaaag tttttatttt ctttagtcct
    15781 tgacctaaaa tatcatcaaa aggtttaaca atactcttca agccattgtt aatgcttgtt
    15841 tgagctcctg atattatacc tggtattgta ttactcattt ctttagctaa ccccatctgc
    15901 tttacactta tgccttccaa tgcttcatca aaagttttat aattttctcc taccagagta
    15961 ttaagagatt ccatgtttcc ttttgctgca cttaagaaag ctgctgatac atcttgttca
    16021 ctacttgtat tcatatttaa agctctaaca tctaccatag cttgagttat atctttttct
    16081 tttttgccac cagtaatatt actaatcatt ttagctttag ttcccattgc aacaacatct
    16141 tcagggtcaa aaggcgtatc atttgccatt cttactaaac tgccataata atcatcaaca
    16201 tctatttgat taacttttcc agtatttctt ttcattacac tttctagaac aactttctga
    16261 ttttgttcct gaccaagtaa atcaacaccc tttttcacag cgacacctat agtagcacca
    16321 tttgtcaaat cagatatctt cccttttatc gaaccaagta ttccacttgc catatccttt
    16381 acagctattg caccactcca taccttacct gcaaataatc tcaatttggg aaatacttta
    16441 cttataatgc cacttgccat atcttttata gctattacac cactccaaaa agtattttta
    16501 aacaacatta acttaggcaa aattctaccc atagcactac tcaccatatc tttaagatta
    16561 atacttcctt gataaggacg tttctctact tgttttaatt ttcccaagat actacttata
    16621 actctcttag tcatatcttt tgcttttatt acgatattcc aaaccttgcc accaatcttt
    16681 tttaaatttc caagtaattt atttttagtt ttttctactt catcactttt agctttaaat
    16741 attaatataa tcataatatt tgaattaaac tcatttttct tttgaatcaa cttattaaaa
    16801 taatcaataa tcatagctat agttattgct agtatcataa tacttccatt taaacttcca
    16861 ataactcctg aaacagcatt tatgctagaa cttaattttg tcatagttga acttacacta
    16921 ctagcagtag tttgaacttt tcttaacgag gaatttaaac tgtttactct attacttgca
    16981 cttccaatag aattttttat gctactagcc attacattag tggaaagtga aacagccaca
    17041 gttgctctcc taaaattatc agttactgat ataatttgat tcatttttgg tgtgtaatta
    17101 tctgtaaggt acatatttat accttcttct ctcacatttc ccattacata ccacctcctg
    17161 tcaaaggaca cactccatat ccatgtttca ttttttcaac ttcttcctca atttctaagg
    17221 cgaaaaaagc ttcaataagc tttaattcgc ctttatccat tgcataaaaa agggacggtc
    17281 ttataccttt tttcttccaa taatagtaca ttattgtagt cctggtatcc gtccctatta
    17341 gttttttacc tcttctatca ctgcattttt accataaccc ataacatctt gaagtattct
    17401 atataagttg gtaatttcac ctggtaataa taattttctt gctaattctt ttggtgttgg
    17461 agccttaaat ttatccatta gctccttatt tttaaataaa agctttccat ccaaatcaca
    17521 aacaccttct ataattgtaa gcatctgcat ctccggtaag tctatatccg ttttcatatt
    17581 ttcatcaatt ttaagacaag tattttgtat ttcttcatct ttacttattg ttaaagctct
    17641 acacattact ttaaattcct gcccaaatat agttgataat ctcttaagtt caactatagt
    17701 actcggtctt tctaagtttt ctgtatctga atttaaaagt aaatctacta tgtttatatt
    17761 ttttgataat ccattttcac tcattattat ttgctccttt atcaatcaaa ttcaatcaac
    17821 taactttttt acttattaac tatctgaatt tattaagtat atatttacta aatatcagta
    17881 taaaaccaaa tataaaacta aatataaaac taaattatat caagaaaatc atactcagta
    17941 aatgtgaaag gtgcttctat ctctcctttt acgccaacct cccaatcagc taaagttaaa
    18001 tcatcaaatg ctatattctt tactgctatt ctttctgctc cataagaatc tgggtcattt
    18061 aatttagata tagcaacaaa cctaggttca gaacctctct ttatcttttc tccaattaac
    18121 ttgtgcattc ttgaactaac gtggtataga gttattgagc cttttccttt atatcctata
    18181 tactttgtat cagtacccat ttgacctgct attataatat cttcttttgt aaattccatc
    18241 tttgcttgaa atttctttac ttctgctact ttgtttccat caagccaaag ttctccccaa
    18301 gtaccactca ttacatttct agcttccata tttgccatat taataatcct cctatatttc
    18361 tattgataaa tctatatctt ccatagcatc aagtactttt atttttgctt ttaaaaatac
    18421 tttagaacct gtgttagctt cttttatttc ttgtaatgtc atataagata aatctactcc
    18481 ttttgatttt aaatacgatt tttgtgcttc aaaatctatt tcaacagtag aatcagattc
    18541 tataagtgct gatttttcta attcttctaa ataacttttt atagctacta tcaataaaca
    18601 tttgttgtca taactgttag taacctttcc tatatagtca tctattatca cctttcttat
    18661 gtcactatgt ataatatcta aagtgtcaac tatttttatt ttctggaaca tttctccttt
    18721 ttctgctgtt aattcagtta aagaatttac tcctctagca attcttatag ctcctgcttc
    18781 tttaataagt ataagctctc ctttattaac ctttgattct gcatcaactt tcgtcatctt
    18841 aggtatatcg actacatcac taagtttagt ataagttact gattgactta aaggtgtacc
    18901 tgctataagt ccagccaccc tacttgtaaa ctcatcaaca ctgtatttct tttctccaac
    18961 taacacatct tctgtagtaa aattaattat cccttcatga tttcctacaa cttttcctaa
    19021 tacagcttta accttaacct tatctatatc tctaagttta attatccaat tttttatagc
    19081 agtcttatca gcttctactg cttttggcat acatagataa ttaaattcct tagtctctaa
    19141 aaaatctaat gcagtttgaa tatctgcttc tccttctatt acataaacta ataacttatt
    19201 tggagtgtta acatttccca tcaaagctaa atttatatat tctttatttt cagcagataa
    19261 atcaactggt atatcctctt tttcatgtat ttcattaaga cctagtgcct tagcatcttt
    19321 aagtaccatt gcaattattc ctctagctga acgttcttta acagttgtag ctagctcctt
    19381 aaatgatatg ttgatacttg gtaatcctat agccatacta tcactctcct aaatttaaat
    19441 tgatttcttc catattttca tatactacat cttcttcata tacactatcc agatagttta
    19501 gtgtaaatgt aaagttcaat acataaattg actcttcttt tttaatactt tgttctagct
    19561 ttgttatatt taattttctg tctgttacct ttatatttct gttgaataac ttatttaatt
    19621 catctgaaac ttcatacatt ctaatactct ttgactgtgg ttttggtaag tattttatag
    19681 agataacaat atctttgtta ttcgtattta acattacagg tgtacaaata actgatagta
    19741 tacttacaaa aaaacaagac ccttcagagc cttgcacact ttcatcatca ataaaaatac
    19801 tttcagtaaa gttttttttg agaatctcaa taattgtttc taatatttcc ttgtatttaa
    19861 gcaaataatc accacactat cactaaatat tcttgcttaa tctgataatc ttactataaa
    19921 tgatataagt catttttaaa tatatatctc atttattcct gtcaagtatc ttctatattt
    19981 ttaggtaata ttattctttt caatctatca cctccttcaa tatggatttc tttcacaata
    20041 acattatctc acatatttta ttgcctattg ttgtaatggt gtatataaag tgttgtaaaa
    20101 ttgtcctatt ttttataata tctcactcaa tttaaatatc atctttttct ttaaattgta
    20161 gcaagatgtt ctatctaagt gtagtttcat agaaatatat gtcatattgt tttttgtctt
    20221 actattataa aaaagattaa aaaattccat ttctatatca tttagacacg ttagagcatt
    20281 ttctatcttc tctttttcta tttctatatc ttctttttcc atttttaatt ttcttaatct
    20341 ttcctctctt tttaacacct cattttccac agaagagctt atgttatatg tgttactagt
    20401 cttttctgta tataccattg ctccacatcc agagtattca ttctcacatc tttttatgtc
    20461 caagttaata ttctttatct ttatatccaa atacttataa ttatgtaatc ttttatctgt
    20521 ttctttaaat aatatatctt ttttgttttc catagtactt cccctttttt atatacttat
    20581 tattagcttc aaatttacaa taatctcttt agtgcacagt tttttactaa tctcacaacc
    20641 ttcaagaaca tattgttcta taactgtata aaaaaaactt cttctatatt ttgttctaaa
    20701 atactagaaa tcttcttagc cataagaagt ccaggatttt ttatgcctct ttctatttga
    20761 gatatataat catttgtaat tccagccttt ctggcaagtt gaatttgtgt catacctttg
    20821 cattttctat aatatttcaa gttattttta aacattgttt tatacctcca ttactattaa
    20881 gaatattttg ttcttcctca cttagattat atagaattat ttgttcttta tcaatagatt
    20941 ttagaaaaaa atattctttt atattttatt agttttattt tttagaacaa tttgttataa
    21001 tctatacata aggtggtgtt ataatgtttg ccaaaagatt aagagaactt agaaaggaat
    21061 ttggattgac tcaaagagaa cttggagaaa aagtaggcgt ttcccaaaga gtcttagggt
    21121 actatgaaac agaaaacaga tttcctgatg aacacatttt aaataaattg gctgatgtat
    21181 ttaatgtatc agttgattac cttcttggaa gaaccttagt taaggaaaat attgatacag
    21241 tagctgcaca tagaaaaaat ccacatgaag agttacctga agaagcacaa gaacaactta
    21301 atgattatat agaattttta ctaaataaat ataaaaaaaa ataaaccata tgatgagcag
    21361 tctatttttc tgctctttta atataattca aaggcaaaca tacattctat tttaggggga
    21421 tttttatgaa taatttggat aagctttttg aattagcttc tcaagaagag ataataattc
    21481 attataccac ttatattgca ggtgatttag aaggactata tataaacaaa catggtatta
    21541 aaattatatc attactcagt aatttaaaac aaaactcaaa aaaattgaca tccatcttag
    21601 ctgaagaact tggacatcat ttcactagcc ttggatacta tgtatcctct tataacgatt
    21661 attatacaaa aattattata gataagtgcg aaaataaagc cttaaaatgg gcttgtgagt
    21721 tcttaattac tgaagaagat ataataaaca taattaactc tggcatcact tgcgtttatg
    21781 aaatggcaga catacttaat gtggatatta ctttctttca aaaaagatta gaatttctat
    21841 cattaaaaaa acagtcttta caacttggaa ataataaata tttaatatta actaatttgc
    21901 cgtatttcta catatttgat ccaatttcat aataaaaata gtagtaattt taactggctt
    21961 aacagtaaaa tctatatatt tattttaaca aattttggtt tctataaatt caatattaat
    22021 atataataat gatatcatat tatttaaaat tctaaaaaca aatatatgct tttgttaaga
    22081 aaggttgttt gatgaatgta taaagaaaag ttgtttgata attattttaa gttcttagca
    22141 ctattatttt ggccaattat gtggtataag tggatagtaa tttcaaatgg tactcttgaa
    22201 aatatgttat ttaccatata tgcaatcgtc gcaattgttt tcatcatttt atattcggtg
    22261 tttatgataa aatataaaga cattacacaa atagatttct tttacaggat aagtactcta
    22321 cttgctttta tatttacact ttttagcttt ttaatatacc caaagagttt atttttcttg
    22381 tatttaaaga ttatttttac tggaatatac ctttattatt caatagtaaa aactcttaaa
    22441 tttaaagatg acgaaggtgt agtgggtatt atgagctcac ttttattaat tgtaataact
    22501 ttgttctact aaatttaatt ctatttgact taatatggct ttaaatatta gacatctaca
    22561 ttattttctg atattattta agatggtagt cttatattaa taatgaaata cactatgaag
    22621 gagttaacta ttatggaaaa aaaagtttta gcaacagttg gagaaaaaga gataactaat
    22681 attgatattg aaaatgcatt aaaatcatta gacccttatc aagctatgca atttaaaact
    22741 gaagaaggaa aaaaacactt attaaatgat ttagtgaatc aagaattatt cttcttagat
    22801 gctaaagaag aaaaattaga tgaagaagaa atatttaaat tagaaatgaa aaagatagaa
    22861 gaaaatgtat taaagcaatt tgctataaat aaagttttat ctagtgttaa tgtaacagaa
    22921 gatgaaaaag taaaattctt tgaagctaat aagagctctt tctctaaacc agaaagtgca
    22981 actgctaaac atatattagt agatagtgat gaaaaagcta aagaaatact tgctcaaata
    23041 aaatcagaag aaatatcttt tgaagatgca gctcttaaac attcttcttg cccatctaaa
    23101 gatatgggtg gtgatttagg aacattcggt agaggacaaa tggttcctga atttgaagaa
    23161 gctgtgttct ctatggctaa aggtgaagta agtgaaccag ttaaaactca atttggatac
    23221 catataataa aattagaaga ccttcaagaa agtacagagt ctacatttga tgaagttaag
    23281 gctgaagttg aaaaaagttt attatatcaa aaacaaaatg aagtttatgg aaataagata
    23341 aatgctctta atgctaagta cggaaacctt gtaaaataca acgattaatc ataaggtcat
    23401 atataaaaaa gctgtctttt cacaatattt attagaaaag acagcttttt atattaaagt
    23461 ttaaatattc agtttcatat tatcattttt ttattgtaaa gaactcagct taaaagttta
    23521 aataagattt ttaattatca ttagctaaat ttttatatcc acgtattatc tcataacagt
    23581 aacctattac atctcttctt tttattatcc caataaatgt gtcttggtca tctataacag
    23641 gaatgaaatt ttgatttaaa gattttataa ctaaatcttc aatatctgcg ttgatggaaa
    23701 caggagaatt atccattttt ctatttatat ctgtcactgg aacatcttcc aatcccttta
    23761 agtccagatt taaatcattt tttaatgtcc ataaaaaatc accttctgtt atagttccaa
    23821 catatttacc atccttactt attattggaa ttgcagagta tttgtgatat tccatttttt
    23881 ctagggcttg ccttatagtg tagtcttcat atatatatgc tacttcactt tttggtgtta
    23941 gaaagaataa tatgttcatt acactaccca ccgttactga aaacttataa atattactca
    24001 atatttataa tgttactttt ttgcagtaac tttctccttt cttattttct aagtattctt
    24061 aatactatac gctgtaacaa gcgtttttcc tttgctcatt ttaatcttat tatgctttat
    24121 taatattttt atatggtcta taagtatcac ttattctctt tttagaaaat ttactaaaaa
    24181 ttaattgact taaacttagc cataataatt ttactctaca ctattaattt taacatattt
    24241 atctcattat taatgatttt attttaataa ttttaattta ttttgctatt aattttattt
    24301 acaaaaactg aaaaaaccgc taaatgatta gcggcttatc tctcatatta ctagaacact
    24361 aatatatatg aatttttaat tataatctaa ctacgttagc agcttgagga cctttagctc
    24421 catctactac ttcgaactca acgctttgtc cttcttctaa tgttttgtat ccatctccag
    24481 ttatagctga gaaatgtacg aaaacatctc cttcaccttc tacagatatg aatccaaatc
    24541 ctttttcgtt gttaaaccat ttaactacac cagttttcat taataaatcc tcctaaaaaa
    24601 acacaaatat ttagctactc ttttctgtaa ccttattact actctatcat atatagctat
    24661 gtttgtcaat tattattatt tttatacatt aataatcaat ttttttactt tataatttta
    24721 aatgattatt atcttttaca ctttattttt ctttataatt ttttaataat ttatttttat
    24781 tatatggaat cttatggact tatcactcca gcctaaatcc catggcacca acattctatc
    24841 agtattatgg caagttacca aaggatatcc tcttgagtct aatcctgtca ctgtcgaaac
    24901 atgtgttatt ctgcctttct tctcataacc aacaaaatcc cctggacgta aattataagc
    24961 ttctttgtat acttcttcat aggaaccttt agcaattaat gaacctcttc cactatacag
    25021 tgcataattt ttaaaagctt gtgcatttac ccatgctttt gtacctgctc tctcgctata
    25081 attccaaatt gagttctttt tgaaccttcc actttcaaac attatctgtg atgcaaagtt
    25141 tgcacaatct ccaccttctg gattataatc cctatagttt ggattaaatt tcataccatg
    25201 ttcttcatca gctgcggctc cacagtattt atgtgcataa tctatagctt ttttttgttc
    25261 atctgtaagc tgtaactcta caccatcttg ttgaccaata taatttctta tatcatcaga
    25321 ttttatattt tctaaattta aagagtctgc aaaagggtct gtataccact ctttagttat
    25381 gacatattga ttatctataa tttttacatt tagataatga tatgtaccta ttctaaaggc
    25441 attttctttg tccttttgat tttcatatga atacttatat tcagtggata ctgaacagat
    25501 tataccatag aggtcttttt ctttttcctt tattttttta atcttaaccc ttgtctttat
    25561 gtctttaaat tttacacctt gtttactaga ccagttttct aaatatttca tcttttttac
    25621 ttcattttca taagcccaca gaccaaattt tttatccgtt tcataaagac cttttaaaat
    25681 attttcattt ttctctaata ttgccttatt tctgtagtca aataagtttt caagcaatag
    25741 tttatattgg tcttttacat catcaccttc aacatttgca gattccatga ctttttcttc
    25801 catatttttc atacttaaat cattgattaa aaatacacct gctgtagtag ctaaagacaa
    25861 aaatacaaat gccattatac ctttgatgta cttattctta tttttcagta ttttcaaagc
    25921 tacacctccc aaatagtaca ccttacaaat caaattacaa agaatattct gtcacatata
    25981 gtaattttca tatttaataa ttctctattt tattatgtcc aatattaaaa attaattgta
    26041 tcaatacact gtttttttta caatttttta ttttataatc tacttttttc ttttttttat
    26101 agtaatatat atgtatataa atattttggt atcattataa ttaatacata ctaatggagg
    26161 gttttttatg caaaaaaaag tcgcagcaat taatgactta tctggaatag gaaaatgctc
    26221 attatcggtt gctataccta tactttcagc attaaaggtt caatgttgtc catttccaac
    26281 ggccatactt tcaagtcaaa ctggttatcc tgaatttact ttcttagact ttactgatga
    26341 aatggtaaaa tattcaaatg tttggaaaaa tttaaaagtc aattttgata gtatatatag
    26401 tggttttttg ggttcaaagc atcaaattga gatagtggct aattttataa acgattatcc
    26461 caatgctttt atcgtagttg accctgtgat gggtgataat ggagttatgt atccaatatt
    26521 cacagaagaa atgagacagg aaattaaaga attagttaaa cattcagatt taactactcc
    26581 taatttaaca gaagcttgtt tcttaactgg aaatgattat accaaaagcg attataatag
    26641 agatgagctt atatatattg caaaatctgt atctgatttg ggacctagca aagtcgttat
    26701 tactggtata ttagaagatg ataatatatt aaatttggct tacaatagag ataatgacca
    26761 tgtattcttt acatcagtca aatataataa ttgttcttac agtggaactg gagatatatt
    26821 cacatctata ctttgtggta tgttagtaaa taaacatgat ttgggagtag cggttaatac
    26881 tgcaacagat tttatatata aaactataaa ttacacatct caatttgata ctgatagaaa
    26941 tgatggagtt atgtttgaaa actttttatc agatttaacc aatatataaa atcaaaaaaa
    27001 ctatccattt tataaatacc tataaatcat aaaatttagg tatttacaaa atggatatta
    27061 tttactaaac tattggtatt tcaattgtta ccatagcacc accagttttc acagaatttt
    27121 caatacataa agtcccatta tgtttttgta caatattatt tacaatatag agtcccattc
    27181 cataatgaga tttagaattt ctactcaaat ctcctgtata aaactgttct gtagcttttg
    27241 acaaatctgc tttagaaaaa ccacttccac aatctgtaac tacaaatttt aagtatttat
    27301 tatgtactga tacacttatg tatagtttac tctggcttgg tgaataatct atagcatttg
    27361 aaattatatt cataatagct ctgaataaca gttctctatc tatagttata tttttaggca
    27421 aattatcttg tttataaaac tccacatcta agtttttagt actagctaat gcttctattt
    27481 gcactaaaac atcttttata aactcactca tactgattgc ttctttattt aatatatagc
    27541 cattctctgt ttttgatata tctattaaag tattaatata tttttctatt tgagtgacac
    27601 cctttgagat atattccatg tattctaata actcaggatt ttcatttatt tcaattaata
    27661 agtcagtatt tccatgtata attgttagtg gtgtttttat atcatgtgcc agtgcagata
    27721 tctgttcctt tctattttct tctagcatcc attgtttttc taaagaatct tttaacgcca
    27781 acttcatttt atccatagaa aaaaggacat tattaatttc ataaatttta ctagattcta
    27841 caacaaaatc taaatcctgt tgttctattt tttctgtagt attttttaaa agctccattt
    27901 caatattaaa tttcttgcca aatacttttg ataatataac aatttcaata aaaaatatta
    27961 tactaaaaat aatcataccc aatgtctctg gttttggtaa atatgctctt aaaattggag
    28021 aactatactc tgatactatt ttgtatttta ttataaaaac ttcatctttc ttaaaaaact
    28081 ttatataact ttctgaatat gcatgccttt cttcaatatc tctcattaaa ttccatactt
    28141 cttttgattc ttttttatta aaggtccctg aaattaaatt cccatccaaa gtataaaccc
    28201 catactcata tatacttgga attatatctt cagttacttt ttcacttgaa ataatctgtt
    28261 ctttatattt attaaattgt ttttctgcat aattagctgg taaaattaca cctgatgata
    28321 ataatacaga aaatgataac attaaaagga gtacaattga aattgtcata ataaagaata
    28381 aagataaata ttttataaaa atagttctta acttttcaac ttttttgttg ttagattttt
    28441 tacctccaag catttgtacc ctgtcctcca atagtttaat taattcataa ttaataccca
    28501 accagttttt tatttgatta ttttatatct ttttattgct aagttatatt ttaacataat
    28561 aatataaata aacagtcaat ttttactcta ttcttctgat tttttacctt cccatttaga
    28621 aaaccaaata cataaaatta caaatgctaa aattgttaca aaaccacaaa ttaaacctgt
    28681 tgattgatat gcttttattg attcaacctt tatatattca accgttttag aacttgaaaa
    28741 agacgaccaa atagttataa atctaacacc ccatgcacaa ggaaaatact gccaaatacc
    28801 agaacccaat ccagttaata ataatgctga aagtaacatt tcaactatac ctactccaat
    28861 tgatgttcct tttccgaacc ttaaacttaa gaataaatgt aatatgtatt caaataaatt
    28921 acacccaatt aaaattagaa ttgaaatcat ataaaagctt gatgtaaagt aagccttaga
    28981 tataccaaat ttaaaaccta atacagacac taatgttgct acaaaaccaa gacatactaa
    29041 gattatatat ttacttataa gagtaagata ttttggatta gatgttgtta acatatgttt
    29101 ataattccct gcataatatt cttgttcaac aaacattgaa cacacaacac ttgacaataa
    29161 aggaaaagct attgctataa cttgtaaata tgctactatc tttagtatat tatcagctcc
    29221 tgaaacctta taataccata aaaacaatcc catccccatt aaagcaatgc aaatgtgcat
    29281 tagtattata aaatttctct ttaattttat taaatcagaa caaaatattc ttattaactg
    29341 tctcatatta cttcacctct ctattattga accaaaccct tgtagctaaa gcaaataata
    29401 caaataaaac aatagatatt aatactcctg gcaaaataac agcattattt aaaaattcac
    29461 ttccctctgg tacaggaaga ccatttggca gaatatgcaa tacaacagcc attaatcttg
    29521 aaggaatcga atatggaaac atataccaca tttctgtagt tgagaaaaca gcaactccaa
    29581 caatagtaaa gaacatattt gttagaactg taacaaacat accaaatttt gaagctaaaa
    29641 acatacaaag aggaatctgc cacataaata gtaaaataat taatatactt gcaatgatat
    29701 tttgacctat tgaaatagtt tctttataga ttatcccaac aaaaactaca cctattgcag
    29761 aaataattga tgctataaaa caacaaataa tacagtaaat catttttcca gtccaaacgt
    29821 ctttcatttc aattggcaat ggtaaaatac cacgatattt acttttttca tcttttaata
    29881 ctattaaaga agatattaat gttaatgctc ctggaagaaa tgtcgtatac caccagttga
    29941 aagcagcatt ttgccctcca cctagtccac acaaaagtat acaaaacact ggaactatcc
    30001 atatcaactt cattccaaaa gttcctttca tcttttgaaa ttccactcta ataaatcttt
    30061 ccatattact gccctctctt tctattttca gctacaactt tcataaaaag ttcttctaag
    30121 ttttgttctt ttgatacttc tccttgataa cccattactc cattagaaat tattcctatt
    30181 tcatctacaa cttgttcaac ttcagacaag atatggcttg ataaaataac tgtaattcct
    30241 tgttttggaa aagaacgaat caattctcta agttcttcaa taccaatagg gtcaagacca
    30301 tttgtaggct catctaagat taaaagtttt gggtgattta ataatgcaat agcaatacca
    30361 aggcgttgct tcatgcctag agagaattga cctgaacgct ttttaaaggt atctcttaaa
    30421 tctacagtct ctaaaacttc ttcaatgcga gagtcaggaa gaccaagtaa agtagtatgg
    30481 acttttaaat tttctcgtgc tgttaaattc tcatatatag caggagactc aataagagaa
    30541 ccaatatttg ataaatcctt tctagtccat ctatgtccct caaacattat ttttcctgaa
    30601 gttggattta aaatcccagt tatcattttt aataaagtag atttcccagc tccatttggt
    30661 cctaataatc catatataga attagattta attgctagtg aaatgttatc aactgccatc
    30721 tgctccttaa attttttaga aactcctttt acctgcaaaa tataattact cataattttc
    30781 atcctttctt ttgtcaaact tatttacaag aatcattcta aatcataaat ataaggattt
    30841 tataagaatt aaaaaacaaa aaaagatgtg ttaaaaacac atcttttttt atcttaattc
    30901 tattaatttt ccattgtagt atatctctac ttcttcaatc caaatgctat tatcttcttc
    30961 ttggatgaca tttttaataa tattatttat agtatatatt atattttgtt cattcaaata
    31021 atcatctttc caagaaactc tacttttttt atctggttct atcaagttta ttttaacaag
    31081 attatctttt tccttaactt ctacttccat gtctaaacca ttaaaatact catttgataa
    31141 tgtatctaag attaatcgca gtttatcctt aagtgaactt tcttcatcaa tctgtaagta
    31201 ctttactatt ttctcatcct ttgaaattat ctctataggt attttagtag tttttttaga
    31261 attaatcatt ttactagttg tttcttcttt tgcatcttca tccttcttta caactgctga
    31321 ttctttagaa tcaactagct caactgcact gatgctataa tccatacatg ccgtactcaa
    31381 taaagtagta gcaattatta aaaaacttac tgctatttta ttcataagta tccctctcct
    31441 aattctcttt cgatacttat tataccatag tatagattat atttttatac ttttaaatca
    31501 atttataaat tattatagta aattatttac aattctaagc tatttgaatt tatttttata
    31561 gtatattctt tctctaaatt cgacagattt ttattcaaaa gcccttttat ttccctcgta
    31621 tttctatact tgttgctatg ttcttcatta tgttcataat catatgaatc attgtcatat
    31681 tcttcatcat tattaaattc ttcaattgct tcttttgact ttatatcaca attaaattta
    31741 tacttattta ctggtatatc aagtcttacc ttagaatttg gaacttctat gtccaggaac
    31801 ttagcaattg gcatatcaga gtacaagtaa aattcacttt cataatttga atttctacct
    31861 attttctctt ttatatttac attttcaggt atatactctt ctatattatt gataaataca
    31921 tctccattct ctgaagatat atccaatgac tctgattcta tgtttacatt tttaacgcct
    31981 aaaattgact ttgttgatag atgaagattg ctattagata ttaagtttaa gttttctaat
    32041 ctatttactt tattttctgt tatagctctg ctaaaacctc cagaagaagt tttatatgtt
    32101 atattatttg aatctacatc atcagatata aataagtacg aacttatact tgatgcattt
    32161 atatctacat tatttggtac atatattcta atttctctat aatcacgtga aaacatacta
    32221 tttatagatg tatttaataa gtggtcgaaa cttctaatct ttttaatttt attttcagat
    32281 tttctttcgc cttttacaac taaagtctta tcttgtaggg ttacactgta tttgtaaaat
    32341 tcattattcc ctcttgttgt cacacgcaca tcttcatttg aactttttct tatcataaca
    32401 tttatattgt caacagctat atctaacttg tcaatattta ctttttcttg ataaagtttg
    32461 ttttctttgt ttaattcagc ttccttttct aaaccaaagt ttattaggct tggcataact
    32521 aaaatccctg accatgttgt ccctattata cctattacca ataaaactgc agcaaatata
    32581 gcaagttttt tattcatgtt tatcttctcc tttcttattt tctatatctt caaggtcctt
    32641 atatatcgcc tcaaaattta tactatcatc attatattca tcagtttctt ttatgctttc
    32701 ttcttctcta ttgtagtaat cattattata tgaattttca ttaatgtctt tattcaaatc
    32761 ttcatcattt aaagtagctt tttttctttt ttccatcttt tcatttgcct ttatataaat
    32821 attttttctc tttatccaat gtatataatt atttagtaat tgtttaccta gttttatggc
    32881 aaataataaa atttgccatg caagtatctc aagccctaca aatgctatgg ttgcgaaaat
    32941 acaaaacatc ataacatctg gaaccattgc tataaattta atcacaaatg gaattaatat
    33001 aacaaaagca attaatgagc atactaatgc aatagtagca gatacaatag cacatacaaa
    33061 cgcaaatgct ggaacaatta gaaataaaga taacactact aataacccct ttataacttg
    33121 tctggataat cctcctacac cttcttctat acttggtgta agtttatcat ttatattttc
    33181 ttttgattta ttgtactttt ccttagcttc atctttcaag atagaataat ccttttttac
    33241 atttgattta aatctactaa atttaccatt taatatgtct gtattcatta tttttccatc
    33301 tatattttct tttgatttac tatacttttc ttttgcttca tcttttaaga tagagtaacc
    33361 ttttttcata tctgatttaa atttactaaa cttatcattc aaaacatctg tatttattat
    33421 tttttcctct tcaatatttt tttctttagt ttgtaagata agttcttttg ctatagattt
    33481 tggtgagcca agtgatgcta ttatctccat atcactcttt ccctctataa gaccatctac
    33541 gaaatactct tcataatctc tcaatatatc attaacttcg ctctcagaaa aatctttttt
    33601 tagataatcc tttaaaattt caagaaactc agttttattc aagttcatta cctccctcat
    33661 cttcacttat taaaatctca acagccttta caaattctct ccactcttcc atcagattgg
    33721 ataaattctc ttttcctagt gaagttattc tatagtattt tctagcagga ccttcattag
    33781 attctagtat atatgtttcg aaatacaaat cttttgtaag tcttcttaga ataggatata
    33841 ttgttccttc atttacatct attactttag agatgttatg tactatctca tatccataca
    33901 tatctttctt agatatgaga gcaagtacac aaatttctaa aacacccttt ctaaattgtg
    33961 tgttcatata ctccatcctt tctttaaata cacagtattg tgttttacaa ggtactatgt
    34021 taaaacttct tatatcctca taataacaca gtactatgtt ctgcacaata gttattttta
    34081 aatattcttg ttgattaaat ccttctataa atgtataata ctctaatcag atatatttta
    34141 tgaaagtggt gataaattgg ctaaaatgaa agatgataaa acaatattaa tcctaactgc
    34201 tcaatttggt gctggacata taagtgctgc aaaagcagtc aaagaatgta ttattgaaaa
    34261 atatagtaac tataatgttg ttatacaaaa ctttataaat gcaagtattc ccatgatgaa
    34321 taagcctatg gtaaaacttt atgaaaacaa tacaaaatat actcctggat tatataatta
    34381 ctattattac tttaagaaat cgtttgattc aagacatgat ttatctcata aattatatac
    34441 acctaaactt tctgagtata ttgctgatat aaatccagat ttgattatct ctacatttcc
    34501 actagctgct gcttgtgtaa ataactttaa gataaaaaat cctgatataa atatacctac
    34561 acttacagtt ataacagatg ttgtagatag tatggaatgg gtttttgaaa atacagattt
    34621 gtattttgtt ccttctcctg aaataaaaaa tagatttttt cagaaaggaa taaatccaga
    34681 ctccataaag gttactggag ttcctgttga taagagattt caaattgaaa gtaaagaact
    34741 atgttgtgat aaatatagac tattacttct aggtggagga agaggtctat ttgatataga
    34801 tgaggatttt atgcattgga tagatgaatt tattgaagaa catagtaatt ctatagaaat
    34861 tacaatagtt actggtaaaa acaaaaaatt atatgacaat ctaactcata aaaaacctct
    34921 aaaaaatatt aaagtacttg gatttgtaaa cgacatgtat aatctaataa gagaatgtga
    34981 cctaatgcta actaagcctg gaggagcaac tatatttgaa gctattcaat cacaaactcc
    35041 agtactcgta aaaatgccaa aagttggaca agaaattgaa aacgctaaat ttataataga
    35101 taagggtctt ggcatgattt atagtgatga cctagacctt aaaaacatat tttataaatt
    35161 agtatcaaat gaatttgatt ctataataaa ctttatgaaa aaaaatttaa aagaatttaa
    35221 aacagtcatt catccagaga aaattgctga ttatatatca gaattaatag ataatcatta
    35281 cagttaaatt gtactattaa aaaatttcaa acataaaatt aaaggcaatc aagtatgctt
    35341 ttacacttga gaatttactc atagtgttta ataatacttg attgccttta tcatatcaaa
    35401 atcaaattgt tatattagta tatatttttc ttgtactgca tatacagttg ttgtatttct
    35461 tccatacttc tctttaattc tatttgtaaa tctgaagcag tctggtaatc cttattttct
    35521 atagcttctc tcactctagt gaatagtgat tctctagtta aagtatcctt cataatattg
    35581 aactttaaat ccgatattga gttccaaact acctcatcaa gcgcatccat attttctttt
    35641 gtgtgtatct tgacaatact tcttattttt tgaatcccag cctctattat tctagttttt
    35701 aatttctttt gccacttatc tatagctcca atcttaaatg attctattat actatcagta
    35761 aatacatcac cttgttttaa agattttaat tttgaagcat atatttctaa gtttttcata
    35821 ttttcataaa ctgtagccgg tggtattcca aatcttgcat ttctttcttc caaactataa
    35881 tgttcaaata catcattttc atctctatat gctctatctt tttctaaata gaaactttct
    35941 tcacctacat ttttagataa ctctttttca agttcttttg tactaagacc actcttagct
    36001 gctgctttta taccatccaa cattgtttga taacatcctg ctattactaa atacgtgtta
    36061 gatagagggc ttggtgacct taactcaaat cttacagtct ttggattttt catatctctt
    36121 attaatccaa caagcactga cctatttctt gatggaatct cataactatg acctaaagat
    36181 gtaactatgc atacaggagc ttcaaatcca ggaactaatc tattaaatcc atcattagaa
    36241 gctgttacaa ttgggtttaa tacttcataa ttgtaaagaa gtcccataag agccccatat
    36301 cctagttcac ttagataatc ttcttttaaa tcttttggcg caaatagatt ttttatactt
    36361 ccatccttta acttcgcact tactcctaca tgtgtatgtc caccacttcc tgctactcca
    36421 tgaattggtt ttgctttaaa tgtaacttct agtccatgtg atgtaaatac atcctctata
    36481 acatctctta ctaataattc attgtctgct gcttgtaacg gtgtagaaaa cttccaagaa
    36541 acctctaatt gctccatagc atggtttgtt cttccatcta tactaataga actttgtatt
    36601 cctccgacct ctttgtgagc catttcaggg tttacaccta gcttttgaag tataattaaa
    36661 cttttctcta aacaagttct tataatacca tgagttcttt tccagtattg ctcttttagg
    36721 ctttgtgata catataattt ctctaagtca gctttatcct caggagtatt aacccagaac
    36781 tcaagttctg tagctgctgt taacattatt tcctctatat catctactga atctattcct
    36841 atgttattta ttacatgtgg atattctcta aatatttcat acattgactt tttaaagtac
    36901 ttatctgctt tttgaagtac tcctctagaa catacttttt tattatcatg tattaaaaat
    36961 gcaggtatct ttaatgttcc aacaggtaga cctacttctt cgtctatata ttccatattg
    37021 taatctacat accaatgaca acttttatct ggcattaaat ctactttcgc attatttaat
    37081 gtagctatat tataaagctc aacacttgaa ccatcagtct gtatagctga ttccaaaaat
    37141 ttatctatat cctccaaaaa taattctaca ggaatctttt catctgttgc atttcctcct
    37201 aaatcaaccc ccattaagga aacaaatctt atatttttat tgctttttag gatttctctt
    37261 aattcttcat tagtgtgttt atctttctct attacgtata atagactatc catttttcca
    37321 ctctcccata atttttatgt atattttatt ttgttaaata caagataaat ttcattttcc
    37381 ttacatttat gaatttttct tgcaaattat tcgtgtttta ttcgtgtttt tatttatatt
    37441 attatatatc aagtataaaa agttcgcaat attttttatt ggaaaaaata ttatacatac
    37501 a
//
LOCUS       DAEHWM010000033        35736 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.034, whole genome shotgun sequence.
ACCESSION   DAEHWM010000033 DAEHWM010000000
VERSION     DAEHWM010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 35736)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 35736)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..35736
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.034"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..1039)
                     /locus_tag="KNP36_001720"
     CDS             complement(<1..1039)
                     /locus_tag="KNP36_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873598.1"
                     /translation="MIRLTIANIKRYLKNHTLLINMVMLPIILIFSLNFFINNSGNQS
                     MYFSPVAIVSDSSGKYEHKLINSSKLKENSFRLNEQDKAMNLLKNNKVSAVFVLDKNF
                     SNSIDKLQRPVVKCFKIENGGGSLWAESQIESFITKSLKLKVDKNIDDKLTKTNIIDN
                     KPDKNKGSFLVVFLICYFMYINAAHLASDLFTLKKSNVLKRLISTDNKDIKIIFSIFL
                     GLFFIQSIVYTFALLCFSIIEDFNLSLNVLMIVLANSFVSTGFVFWVARVFKNESSIS
                     LISTFYSLIGLAISISSLIPSMDKLSFMTNLSKFTPFYWTIDAIKNNGSILINIIALI
                     LIGIIFVTAGSL"
     gene            complement(1042..2139)
                     /locus_tag="KNP36_001721"
     CDS             complement(1042..2139)
                     /locus_tag="KNP36_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873599.1"
                     /translation="MKLYMSVKTMLKSLKSSFILNLIYFLALPLILSWFLGMVTESMF
                     QNPIKTESTPIVIYDKDNTRLSNDLTKYLKNDLSYILTVKKDDSKAELKLTIPKGYES
                     SLLNEKSNTLNIEKLGTRDDIAILLQDILDTYHEKFYLNNSQKISSEDFSKLFNKNSI
                     DTSIINNNVKQSSYEYFALVSLGFLVIIFIMNNILSNYISESKGLSKRLYSMPITRVQ
                     FLIYDFVGLWIYSFIFLLLYVLFFRILGITFKGNFAILLLLCALSSYFMTSISTFVTS
                     FFSKKYGTAIVYALLFLQTIFGGIFSMISDTFTKLTSLSPTYLIGELFSNYETFKTID
                     SIGNLIFTCLIISTILIALAIVKEKYKWREV"
     gene            complement(2153..3088)
                     /locus_tag="KNP36_001722"
     CDS             complement(2153..3088)
                     /locus_tag="KNP36_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873600.1"
                     /translation="MDIVRVNNITKRFNDKLVLDNISFSVKKGEIFGLIGPNGAGKST
                     LINIITNLMLPNSGSIQINGLDLSKDYIKAKSIIGLVPQELAIIETLTPFDNLEYFGA
                     FYGLKGKLLKERIIEALEVTGLTEVKKKKVKKLSGGMQRRLNIGIALLNHPKILILDE
                     PTVGVDPQSRNHIFNFIKDISKKHETTVIYTSHYMEEVEHLCSKIFIMDEGKEIAFGN
                     NDYLKSLVSTNTKLIMEIKNINAQLIFDLKNTKGVISVLENNSLLELDIDKKLQLTDI
                     LSVIDKNNSKIMKISYEEPSLEDVFLNLTGKNLRD"
     gene            complement(3217..3864)
                     /locus_tag="KNP36_001723"
     CDS             complement(3217..3864)
                     /locus_tag="KNP36_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873601.1"
                     /translation="MNKIKVLIVDDEKLIRKGLKIILSSYNDLEIVGDASNGYEALEF
                     CKMNDVDIVLMDIRMKVCDGVLGTRLIKEYNNSITLLILTTFNDDEYIKDAMKFGASG
                     YLLKDSSDEVLHEGIRSSFFGNIVLDKSVAEKIMTSEKTIKQEHLYDMYNLTEKEISI
                     IRLIANGLNNKEISQELFLSEGTIKNNITNILAKLELRDRTQLAIFAFKNKIVIE"
     gene            complement(3857..5020)
                     /locus_tag="KNP36_001724"
     CDS             complement(3857..5020)
                     /locus_tag="KNP36_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0873602.1"
                     /translation="MNREKLVAFIRYLSLFILVVSYLKNVENTLYPVITMIILFLIII
                     NNQVRFFSLSNENKFILISYFLELILIFILCNYTKTFNSIYFVPLILDISFLIKEKYK
                     YILFSFVIISSLIISLDKNIYLALESSSILLIITVLSIYIENENLSKLYSQNLYDKLR
                     ISKDELKKVNADLETYASSIEELAILKERNRISREIHDSVGHSLSTTIIQLNAIEKLL
                     KDKPLIYDLVHELREFVTESFQDVRRAISELKPVEYENYQSLFKIKELVKSFIKLTNI
                     NVKLTISKNTWNLSRNQSIALYRLIQESLSNSSMHGKATEIRIFITFNTSNLIITISD
                     NGIGCGNIKKGNGLNSINERIYELNGKVEFDNSNNGFTIRASFPKFSGGDFFE"
     gene            5204..5548
                     /locus_tag="KNP36_001725"
     CDS             5204..5548
                     /locus_tag="KNP36_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YraN family protein"
                     /protein_id="HBF0873603.1"
                     /translation="MNNKEKGDFGEKVAVNYLLSKGAKILEKNYRLKIGEIDIIAKME
                     DEIIFVEVKSRSNIKFGYPCESVSFKKRKKIIGVANYYIIKNNLNNTPIRFDVIEVYL
                     LEKRINHIMNAF"
     gene            5579..7180
                     /locus_tag="KNP36_001726"
     CDS             5579..7180
                     /locus_tag="KNP36_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YifB family Mg chelatase-like AAA ATPase"
                     /protein_id="HBF0873604.1"
                     /translation="MLSIINSSNLVGIDSFLVKVEVDVSNGIPSFNIVGLPGKEIKEA
                     RERVKSAILNSGYKFPSTRIVVNLSPADIKKEGAFLDLSISIGLLRELIKKDENYIRE
                     SMFIGELSLDGKIRKVRGILPIIMGAKTQNIKRIFIPIENIKESLFVDEIDIIPIKSL
                     KECVDFLNEEIKVDKVRIMSFLDDKSRKENEELEKDNSYIDCKYTKINNEESKYDEDF
                     KDVKGNYFVKRSAEIAAAGNHNMFMIGPPGSGKTMIAKRVRTILPDISVEEMIEVSKV
                     YSILGMINETKGIIDKRPFRAPHHTTTKQSLIGGGMDARPGEIALAHRGILFLDEIAE
                     FDRKILETLRQPIEDGYVNISRVKYSAKYPCRVLLVAAMNPCPCGYYMSETECRCRSN
                     EIDRYINKISGPLLDRFDIFVEVNSIKYSDFNSLKQEESSQKIKRRVENARKIQINRF
                     KKDNIKNNSEIKAYNLFKYCKLEKEASKTAEMIFSKYNLSSRSYTKLLKMARTIADLE
                     ERDLINSQCIIEAFSFRKAYYSYFK"
     gene            7199..8299
                     /gene="dprA"
                     /locus_tag="KNP36_001727"
     CDS             7199..8299
                     /gene="dprA"
                     /locus_tag="KNP36_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HBF0873605.1"
                     /translation="MEKRDTYLWLKSIGGITTKTIEIIENEIVNIEDIFDFSEKEIYN
                     LKNISLNIRKNIVKYRGHAYLENIKELLYKKAIKYICKYDKEYPENLKNIYNAPKLLF
                     YKGDIGLVNNNFNIAIVGSRKPTAYGINCAKTISCQLSQYGVNIVSGLAIGIDAYSHI
                     GCMSGKSKTIAVLGSGVDNPLPKQNLHLSNKILENGGLLLSEYNINSTVAPYHFSNRN
                     RIISGLSDGVVVVEAAIKSGALITVDFALEHGKNVFAIPGNINSQMSRGCHKIIKEGA
                     KLIENIDDILNEYNIFNIIDKKINQKYDNISLNAKSKQIIEAIKREGNLHIDSICDYT
                     GIEIKYVNSIINELVLNELVVEMNNKTYSLNV"
     gene            8332..10419
                     /gene="topA"
                     /locus_tag="KNP36_001728"
     CDS             8332..10419
                     /gene="topA"
                     /locus_tag="KNP36_001728"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HBF0873606.1"
                     /translation="MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLG
                     VDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLD
                     ESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVR
                     KGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKI
                     ELENEEAVNEILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKT
                     MMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNIGD
                     KKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVF
                     DILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQ
                     HFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIV
                     TDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEK
                     VNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGD
                     IILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKE
                     CNKETKEHNDGKE"
     gene            10584..11369
                     /gene="codY"
                     /locus_tag="KNP36_001729"
     CDS             10584..11369
                     /gene="codY"
                     /locus_tag="KNP36_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HBF0873607.1"
                     /translation="MASEVLQKTRKINKTLQTSGGSSVSFDLLAGALGDVLSSNVYVV
                     SAKGKVLGLHLNDVQDSSVIEDEYTKQKKFSDEYTQNVLKIDETLENLNGEKILEIFP
                     EEHGRLQKYTTVVPILGSGQRLGTLVLSRYSNSFNDDDLVIAEYSATVVGLEILRAIG
                     EELEEEMRKKAVVQMAIGTLSYSELEAVEHIFAELDGKEGLLVASKIADRVGITRSVI
                     VNALRKFESAGVIESRSLGMKGTHIRILNDKLTDELKKLKNNQ"
     gene            11476..12741
                     /locus_tag="KNP36_001730"
     CDS             11476..12741
                     /locus_tag="KNP36_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HBF0873608.1"
                     /translation="MPLADKIRPKTMNDVIGQSHIIGNGKILSKILQSNFLPNMIFFG
                     PPGVGKTTVAEIIAERSNKSFYKINATNSSLEDIKKVISELGSINNVNGVLLYIDEIQ
                     SFNKKQQQSILEFMENGSITLIASTTENPYHYVYKALLSRSTVFEFKPLEKLDIEKGL
                     KRAVEVLNEDSYMDIECNNDAIEDIAILSDGDMRRALNILEVVVYSTKPNKDNITYID
                     SDVIRASTFNKIINYDKNGDSHYDILSAFQKSIRGSDPQASIHYLARLIKGGDLISIC
                     RRLLVIASEDIGLAYPNAIVIVKACVDSAMQLGFPEAKIPLAEATILLATSPKSNSAC
                     IAIMKAMDELDKEFVKDIPNSIKDAHYSGSKEIGRGCGYKYPHNFKNHYVKQQYLPDS
                     IKDSIYYIPQENKTEKNIKKYLEYLNSDF"
     gene            12772..13542
                     /locus_tag="KNP36_001731"
     CDS             12772..13542
                     /locus_tag="KNP36_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0873609.1"
                     /translation="MIIKLNSTYHSRVMKYLKKEPEYNLFIIGDIERYGYGNNFLNIW
                     ADVGEHGEIKAILLKYFEFMMFYSDGEYDVEGFYNLLRNTNYEEISGKICAVDALAKR
                     LGLNNLKVVDFCKLQTKKFLIDNNCNAKVKRIRLGNLKKTVKLYDLIDEFHSTTLENL
                     KNGLRTGRGYCIEINKQVVSMAKSTSENRTHAMIIGVGTHPKYRAKGLATKCLIKLCS
                     ELLRENKIPCLFYDNEEAGKIYKKLGFENIGKWGIYSK"
     gene            13651..14097
                     /locus_tag="KNP36_001732"
     CDS             13651..14097
                     /locus_tag="KNP36_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HBF0873610.1"
                     /translation="MKLSTKGRYGLKAMFELALNQDNGPVSLKFIAKKQKISDQYLEQ
                     IFSSLKKSGLVKSVRGAQGGYLLSKNAEDITVGDILVVLEGPVALSDCVLDEDVCENS
                     NMCVTKIVWEKMKKGIEDVIDSITLKDMINDYNKNKLENDITNIKK"
     gene            14115..15308
                     /gene="nifS"
                     /locus_tag="KNP36_001733"
     CDS             14115..15308
                     /gene="nifS"
                     /locus_tag="KNP36_001733"
                     /EC_number="2.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase NifS"
                     /protein_id="HBF0873611.1"
                     /translation="MEKRRLYMDYSATTPIKKEVLDAMMPYLTDYFGNASSFHTFGRE
                     AKDALDKAREQVAALINAEPSEIYFTAGGSESDNWTLEGVAYANKNKGNHIITSKIEH
                     HAILHTCEYLAKHHGFEITYLDVDSEGKVDLKQLEDSIKDTTILISIMFANNEIGTIQ
                     PIKEISEIAKKHKILFHTDAVQATGNIPVDVKELGIDLMSMSSHKIYGPKGVGALYIR
                     KGVRLHNFVHGGAQEKSKRAGTENIPAIVGYGKAAELAKENMQNHVETLTRLRNKLID
                     GVLERIPYTRVNGSLENRLPGNANFAFQFIEGEGILLLLDMLGIAGSSGSACTSGSLD
                     PSHVLLAIGLPHEIAHGSLRLTVGDFTTDDDIDYILENLPKVIERLRSMSPLYDDAKK
                     QGLVK"
     gene            15362..15802
                     /gene="nifU"
                     /locus_tag="KNP36_001734"
     CDS             15362..15802
                     /gene="nifU"
                     /locus_tag="KNP36_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly scaffold protein NifU"
                     /protein_id="HBF0873612.1"
                     /translation="MQYSDKVMEHFMNPRNMGEIDNASGVGEVGNPTCGDIMKIFLDI
                     DGDVIKDVKFKTFGCGSAIASSSMATEMIKGKTIKDALELTNKAVAEALDGLPPVKMH
                     CSVLAEQAVKAALIDYAQKNNIHIPELDGYVIDDAHDHDVEEEE"
     gene            16091..17170
                     /gene="mnmA"
                     /locus_tag="KNP36_001735"
     CDS             16091..17170
                     /gene="mnmA"
                     /locus_tag="KNP36_001735"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HBF0873613.1"
                     /translation="MNKKVMIGMSGGVDSSVAAYLLKQQGYDVIGVTMKLWQDDDVVE
                     IEGGCCSLSAVEDARRVANKIGIPFYVLNFREVFKEKVIDYFIDEYLEGKTPNPCIAC
                     NKHIKFDDFYKKARQIGCDYVATGHYAKIEKDESTGRYLLKKSVTDKKDQTYALYNLT
                     QEQLEHTLLPIGDYEKDRVREIAKEMGMAVHNKPDSQEICFVKDNDYANYVKKHSKKR
                     IEEGFFVDTKGNILGKHKGILYYTIGQRKGLGITFGKPMFVIDINPINNTIVLGDNED
                     LFKKELIAKDVNFISIDTLEEPLRVQAKIRYSAKPSPATIHRVGEDTIKIVFDEAQRA
                     ITKGQSVVMYDGDIVVGGGIIEKSL"
     misc_binding    17313..17551
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            17619..18203
                     /locus_tag="KNP36_001736"
                     /pseudo
     CDS             17619..18203
                     /locus_tag="KNP36_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428286.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
     gene            18939..19163
                     /locus_tag="KNP36_001737"
     CDS             18939..19163
                     /locus_tag="KNP36_001737"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873614.1"
                     /translation="MNIEQKRPKEEILIDKDIIDQKGTTQLGYGDNHRGYVSIGGNRY
                     KYTRRLKDPFLVLDGETPYIYTLELDSKII"
     gene            19432..21273
                     /gene="ltrA"
                     /locus_tag="KNP36_001738"
     CDS             19432..21273
                     /gene="ltrA"
                     /locus_tag="KNP36_001738"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HBF0873615.1"
                     /translation="MYNTETKAILNKDLKPLKKDMLRFNEYYNMQHIFDNLYKQSQQG
                     SKFSNLYNIIVSNENILLAFRNIKTNAGSRTPGINRHNIKYWKEKPTEEYLQYIKRRL
                     ENYRPQKVRRVEIPKANGKMRPLGIPCIEDRLIQQCIKQVLEPICEAKFHPHSYGFRP
                     NRSAEHAIAYMMKKINLEKMYMAIDIDIKRFFDNVNHSKLLKQMWSIGIRDKKVLSII
                     SHMLKAKVENVGIPDKGVPQGGILSPLLSNIVLNELDWWISNQWQTFNTKYPYIHPSH
                     KYRALRRTNLKEMYIVRYADDFKILCKNRNQAKRIFTATNNWLKERLGLEISEEKSKI
                     TDIRNSNSEFLGFKLKAYKKKKKYVIQSSMSDKAIKQNINNIKEQYNVIKHYPINKNI
                     YTLNRIIAGSHNYYKIATNVYRDFTNIQYNLSKCYKNRLSNLVTKQGAVTQEYLNKYM
                     QYGIKEKYIADAVIYPLTGIKTTMPHVFNQKVTNYTNEGRQIIHSTLGYIDHEMLNYI
                     AKNPIPNRSVEYNDNRLSRYSAQQGICQISKRLLNEDMECHHVIPRSLGGDDRYRNLI
                     LILPFVHKLIHATKQETINFYLEELDLNKQDIKRVNNYRVKVGNELI"
     gene            21376..23430
                     /gene="alaS"
                     /locus_tag="KNP36_001739"
                     /pseudo
     CDS             21376..23430
                     /gene="alaS"
                     /locus_tag="KNP36_001739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428286.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
     gene            23455..23712
                     /locus_tag="KNP36_001740"
     CDS             23455..23712
                     /locus_tag="KNP36_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HBF0873616.1"
                     /translation="MEKDLDYTMKFEGIPEDRMSVGDTIDFVYKALVEKGYNPINQII
                     GYLLSGDSSYITSHKNARAIIKKFERDEILEEVITHYLNRK"
     gene            23722..25893
                     /locus_tag="KNP36_001741"
     CDS             23722..25893
                     /locus_tag="KNP36_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873617.1"
                     /translation="MRKKIMSLFAIVIMIFVSTASYGFAEEKGKVIFIDMNRTNLGSM
                     MNIPILKNEIEKRGYVALMNIRGDQGTDDRRSYASMGAGTRASVTTEDYINFQKVDQD
                     TAKAFEVATGQKAKEINDLGINRSINENLEYGEYGANLGSLGKTLSENGLKTSVIGNA
                     DIIENNQLVKNRNLCLVAMDQYGRIDSGNIDNINKKDSKMPFGISTDYDKLLDETKKS
                     YKNSDAIFVELGDTYRLDMYRLNLNDNTYDIMKKNIVKNINKYLEQVFSMVGENDTVY
                     IASAFPSDLDYKNKRRLSPIIKFSGEGKGLLESATTRKAGIVANLDVGVDILGTFGLE
                     NKEMVGRSYTLVNKEDNISYLKSLYERIVSISSIRSTIINGFVGVISASWVIAMFAIF
                     FRNYMPHKERVFKVLKEFIKLGIIMPLSFMLAPLMNFKTPISISLGIFATTLILYLLG
                     RKLFKDNDIKHMGFFATLTILVIVIDSVFGTYLMQNNIMSYDAVIGARYYGVGNEYEG
                     VTIASAVFGLAVLLHYKKVSKLLVVIFSLIILITSAYPSMGANVGGAISECVAYLLFI
                     MLIYDIKIDFKKAVLLAVSAVVVVFAFAALDILSGSESHLGMFVQRIFLNGPGEILQT
                     FGRKIQMNMQLAQTSVWVNILLVGIGVIAVLIFKPSRHFRKIMNNFPILFKGFIASMV
                     GCIITLLVNDSGIVAASTASIYILIPLIIISINMIIFEKNN"
     gene            26099..26524
                     /gene="ruvX"
                     /locus_tag="KNP36_001742"
     CDS             26099..26524
                     /gene="ruvX"
                     /locus_tag="KNP36_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HBF0873618.1"
                     /translation="MLDGRIMGLDVGDKTIGVAVSDLMGLTAQGVKTIKRVGKKKDIE
                     ELKAIIKEKQVNKIVSGLPKNMNGTLGPQGEKVIKFCELVKAETGIDVEFWDERLSTV
                     AAERSLLEADVSRQKRKKVIDMLAAVIILQGYLDFKINS"
     gene            26602..26889
                     /locus_tag="KNP36_001743"
     CDS             26602..26889
                     /locus_tag="KNP36_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HBF0873619.1"
                     /translation="MEENIINLIDENGVESQFEIILTLEAEGKEYAILMPLDDEEAEE
                     ALIFRIDEDEEGEILIPLESDEEYETVVAVYTAIMEEEGLNYDEDESNGLN"
     gene            27171..27629
                     /locus_tag="KNP36_001744"
     CDS             27171..27629
                     /locus_tag="KNP36_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor"
                     /protein_id="HBF0873620.1"
                     /translation="MANTMDLLKDKLKETGFKITPQRRAIVEILLKHDHSHLSSEEIY
                     DLVRVDCPEIGLATVYRTMQLLDEIGLISKLNLDDGCIRYEISLHKEDCHNHHHLICK
                     NCGKIMEAKEDLLDNIEKEIQSLYKFKILDHDVKFYGLCDECNGVSDSEE"
     gene            complement(27746..28483)
                     /locus_tag="KNP36_001745"
     CDS             complement(27746..28483)
                     /locus_tag="KNP36_001745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBF0873621.1"
                     /translation="MRGKTHCAIGILTAIQTSLIFKIPISLVDILVSATFAVLPDLDK
                     SNSMVSNFILKNNVSKYIYRIFIYAVNIIIFFISININDNFYLSAIITFVAIIIIEAK
                     LTHTFLRKVFLSLIFILLAICLYIIEVEIYFTIFCLMLSIFPWLKHRSFSHSIFATII
                     VYFLLKQIELITNINNLSFYGTIGYASHMFLGDLFTKQGIPIFYPLSEKKISLGFLTV
                     GGPFSNFIEKSFIFVLIGLIIFSILKL"
     gene            28700..30376
                     /locus_tag="KNP36_001746"
     CDS             28700..30376
                     /locus_tag="KNP36_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HBF0873622.1"
                     /translation="MQLFKKNTNKIKVMALGGLNEVGKNMTVVEYKDEIIVIDAGLSF
                     PEDEMLGVDIVIPDITYLVKNRDKIKGIFITHGHEDHIGALPYILKKINVPVYGARLS
                     IGLIQVKLKEHKMNNVKLNVIGPRQVIKLDNMEVEFLKNNHSIPDAYSIAIHTDQGII
                     YHTGDFKIDLTPIDGDVMDMHRICELSKKGVLLMLADSTNAEKPGFTMSEKTVGVGLD
                     ELFAKGNGRRIIVATFASNIHRLQQIINTAEKFNRKVAISGRSMVNVVGVAKELGYLD
                     ISDDMLIDLNDICKYEDSELVIITTGSQGEPMSALARMAFSEHKKVEIKSGDLVIISA
                     HPIPGNEKLISRVINFLFEKGAEVVYSDIADIHVSGHACQEELKLIHALVRPKFFMPA
                     HGEYRMLKRHAEIAEQLGMDKENIFVMQTGDVLELDKNSAKVANRIQTGNILVDGLGV
                     GDVGNIVLRDRKHLSEDGLMIVVVTISKDEGKVLAGPDIISRGFVYVRESEDLMDGAK
                     DIIKNVLNECEEKNIKEWAYLKNNIKENLKEYLYQKTKRNPMILPIIMEV"
     gene            30582..30782
                     /locus_tag="KNP36_001747"
     CDS             30582..30782
                     /locus_tag="KNP36_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore protein"
                     /protein_id="HBF0873623.1"
                     /translation="MDDVSRQNAIKALKQTKMEIAGEYGMNYEDAFEIIENASNKGVL
                     EGYFKKLEKKKNLGQGISRHLE"
     gene            30836..31999
                     /locus_tag="KNP36_001748"
     CDS             30836..31999
                     /locus_tag="KNP36_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBF0873624.1"
                     /translation="MKKLASTALAILIALTPLSFSFANNKENADANQLNISSKSAILM
                     DVGSGQILYEKDAHKKLPPASVTKVMTMLLIVEALDSGKIKLDDEVQVSETASSMGGS
                     QIFLEPGETQKVDTLLKGIAVASANDACVAMAEHLAGSVEGFVDRMNAKAKELNMNDT
                     HFANTNGLPVANHYTSAHDIALMSRELLKHEMISKYLTTWMDKVVVGKKQVTVGLANT
                     NKLIKHYQGATGVKTGFTQEAKYCLSASAKRGNTHLVAATLGAETSPERFNDASSLLN
                     YGFANYESVKLCSKGDNIATLTLDKADENKVKLVAKEDLNALIKKGSSKEFEKKIEIV
                     KNPKMPIKKGTVLGKIKICKDKKVIGEVELINTKDINKASYLQMLQRIIDNMI"
     gene            complement(32210..32632)
                     /locus_tag="KNP36_001749"
     CDS             complement(32210..32632)
                     /locus_tag="KNP36_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2000 domain-containing protein"
                     /protein_id="HBF0873625.1"
                     /translation="METKNSKCVMVIDENLPMGIISNTAAIMGITLGKHAPETVGPDV
                     IDKTGNSHLGIIDIPVPILKGNKEIIKDLRKKLYTLEFNDLTVVDFSDVAQSCNLYEE
                     FTQKIASVPEDELQYFGIAIYGNKKKVNKLTGSMPLLR"
     gene            complement(32653..33489)
                     /locus_tag="KNP36_001750"
     CDS             complement(32653..33489)
                     /locus_tag="KNP36_001750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0873626.1"
                     /translation="MRQEERTVCFDRELKIEAYRFKGIMQKFPNHFHEHYVIGFIEKG
                     QRYLSCKNKEYTTSTGDLLLFNPFDSHTCEQIDDKVLDYRCINIKPEIMKKTVFEITG
                     KNYLPKFNQPVIFRSELVPLLQELHYIIMEEELDFKKEELFFFLIEQLIEEHTEPNLQ
                     SNLENTNIEIQAVCDYLENNYAEHIVLDELSTIAGMNKYSLLRNFTKLKGITPYRYLE
                     NIRVNKAKKLLEKGVEPIDAAIQTGFVDQSHFTNFFKNFIGLTPKQYQNIFINDDSNN
                     FK"
     gene            33787..34383
                     /locus_tag="KNP36_001751"
     CDS             33787..34383
                     /locus_tag="KNP36_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HBF0873627.1"
                     /translation="MLSMNIGEIVASLVGIAMAISIHEFGHAYSAHLLGDDTAKAYGR
                     MTLNPVRHVDPIGLLAMFILKIGWAKPVPVNPNNFKNYKIGNLIVSLAGVFCNVLTAI
                     LCVIINKYVHMYAINTIAEYVFLYSIGFAAFNLLPIPPLDGWGVISTFVPYKWNEYLY
                     KFESMSYIILLIALFTGMYRIILTPIYAVLLKIVYLFV"
     gene            34413..35132
                     /locus_tag="KNP36_001752"
     CDS             34413..35132
                     /locus_tag="KNP36_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HBF0873628.1"
                     /translation="MKYNIQLQVYEGPLDLLYDLITKHKIDIKDISIIDITKQYLNYL
                     KMLDKMDLEITSEFITMASKLLEIKSKYLLYKQKDEEEDPRIELMEKLEEYRKFKVAS
                     QDIKENITYVNERFYRNKEEIIIDDNVDLEDISIEAIKNILPYIFKVKTSQIENANDE
                     KLDKIVRKKIISVEEKILYIRDIIKEKIEVTFTNIIKSYENDEIIATFLSILELIKEK
                     EIVVVQDIFFDDILIRKSSEC"
     gene            35134..35673
                     /gene="scpB"
                     /locus_tag="KNP36_001753"
     CDS             35134..35673
                     /gene="scpB"
                     /locus_tag="KNP36_001753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMC-Scp complex subunit ScpB"
                     /protein_id="HBF0873629.1"
                     /translation="MKREDIKYIIESVMFAYGEPISIKELNYIINKELSSKEIEIMLN
                     LLIEEYREQNRGIQIIKLENKYQMCTNKDYAEYIKKIIEPKKKKSLSQATLETLTIIA
                     YKQPITKVEIEDIRGVKCDKVLQTLFENELIREAGRLNKIGKPIIYKTTDEFLKLLNI
                     ESLEELPPIENYQEVATNE"
BASE COUNT        14273 a         4001 c         6125 g        11337 t
ORIGIN      
        1 taagacttcc tgcagttaca aatataattc caattaatat tagagctatt atatttatta
       61 aaatactacc attgttttta atagcatcta tagtccaata aaatggtgtg aactttgaaa
      121 gattagtcat aaaggataat ttatccattg atggtattag actagagata gatatagcta
      181 gacctattaa agaataaaat gtagatataa gacttataga actttcattt ttaaatactc
      241 tagctaccca aaatacaaat ccagtggaaa caaaactatt tgctagtaca atcatcaata
      301 cattcagact caaattaaag tcttctataa ttgaaaaaca taatagagca aaagtgtata
      361 caattgattg aataaaaaat agtcctaaaa atatactgaa aattattttt atatctttat
      421 tatctgtaga gataagtctt tttagcacat ttgatttttt taatgtaaat aaatcagaag
      481 caagatgtgc cgcattaata tacataaaat agcatatcaa gaagactact aaaaatgaac
      541 ctttattctt atctggtttg ttatcaatta tatttgtctt tgtcaattta tcatctatat
      601 ttttatccac tttcaatttt aacgatttag taataaaaga ttctatttgt gattctgccc
      661 aaagactacc accaccattt tcaattttaa agcatttaac tacaggtcgt tgtaatttat
      721 ctatactatt tgaaaaattt ttatctaaaa cgaatacagc agaaacctta ttatttttta
      781 atagattcat agccttatct tgttcattta atctaaatga attttctttt aatttagaac
      841 tatttattaa cttatgttca tactttcctg aagagtcaga tacaattgct actggagaaa
      901 agtacattga ttgatttccc gagttgttga taaaaaaatt aagtgaaaaa attagtataa
      961 taggaagcat aaccatatta attaaaagag tatgattttt tagatatctt tttatatttg
     1021 caatagttaa tctaatcatt attaaacctc cctccattta tatttttcct ttacaatagc
     1081 aagtgcaatt aatattgtag agataattaa acatgtgaaa attaaatttc ctattgaatc
     1141 tatggtttta aatgtttcat aattactaaa caattctcct attaaatagg taggagataa
     1201 acttgtaagc ttagtaaatg tatcacttat catactgaag atacctccaa aaattgtctg
     1261 taaaaagagt aatgcataaa ctattgctgt accgtatttt ttactaaaaa agctggttac
     1321 aaaggtagat attgaagtca taaaataaga tgataaagca caaagtagga gcaatatggc
     1381 aaaattacct ttaaatgtta ttccaagtat tctaaagaat aaaacatata ataataagaa
     1441 tataaatgaa taaatccata aacctacaaa gtcataaatt aagaattgta ctctagttat
     1501 aggcatagaa taaagtcttt ttgaaagtcc ctttgattca cttatataat ttgacaaaat
     1561 attgttcatt ataaaaatta ttacaagaaa tcctagtgaa actaaagcaa agtattcata
     1621 agagctctgt ttaacattgt tatttattat agaagtatca atagaatttt tattaaataa
     1681 tttagaaaaa tcttctgaac ttattttctg agaattattt aaataaaatt tttcatggta
     1741 agtatctaat atatcttgaa gcaatattgc aatatcatca cgagttccaa gtttttctat
     1801 gtttagagta tttgattttt catttaataa actactctca tagcctttag gtatagtaag
     1861 ctttaattct gccttagaat catctttttt aactgttaat atataagata aatcattttt
     1921 caaatacttt gtcaaatcat ttgataatct tgtgttatct ttgtcatata taacaatggg
     1981 ggtagattct gtttttatag ggttttgaaa catgctttct gtaaccatcc caagaaacca
     2041 agataaaatc agaggcaaag ctaaaaaata tattaaatta agtataaagg agctttttaa
     2101 actctttagc atagttttta cactcatgta taatttcata aaatcacctc cattagtccc
     2161 ttaaattttt tcctgttaga tttaaaaata cgtcttctag gctaggttct tcataagaaa
     2221 ttttcattat ttttgaattg tttttgtcaa tgacagagag tatatctgta agttgtaatt
     2281 ttttatctat atccaattct aataatgaat tattttctaa aacagatata acacctttag
     2341 tattttttaa atcaaagata agttgggcat ttatattttt tatttccata attaattttg
     2401 tatttgtaga tacgagtgat tttaaataat cattatttcc aaaagcaatt tctttacctt
     2461 catccataat aaaaatttta gaacaaaggt gctcaacttc ttccatataa tgggaagtat
     2521 atattacagt agtttcatgt tttttagata tatcttttat aaaattgaaa atatgatttc
     2581 ttgattgggg gtctacacct acagttggtt catccaatat taatatttta ggatgattta
     2641 agagtgctat tccaatattt aatctccttt gcataccacc agataatttt ttgacctttt
     2701 tctttttgac ttcagtaaga cctgtaactt ctaatgcttc aatgattctt tctttaagta
     2761 gttttccctt taaaccgtag aaagctccaa agtactctaa gttatcaaaa ggggtaagag
     2821 tttctataat tgctaattct tgtggaacta accctattat agactttgct tttatataat
     2881 cttttgataa atctaaacca ttgatttgaa tactaccact atttggtaac ataagatttg
     2941 taattatatt tataagtgta gatttacctg caccatttgg gccaataagt ccaaatatct
     3001 cacctttttt aacagaaaag ctgatgttat caagtactaa tttatcatta aatctttttg
     3061 ttatattatt tactctgact atatccatag taatccctcc aaaataattt tgtataagtt
     3121 aaaaagctat aatattataa taaagaattg tgaattataa ttctattact ataagtcact
     3181 aaaaaaagtg acttaagtca ctttatattt ttagatttat tctattacaa ttttattttt
     3241 gaaagcaaag attgctagtt gagttctgtc acgaagttct agtttagcta aaatattagt
     3301 tatgttattc tttattgtac cttcagataa gaatagttct tgacttattt ctttattatt
     3361 aagtccattt gcaattagtc taattataga tatttctttt tctgttaaat tgtacatgtc
     3421 ataaagatgc tcttgtttaa tcgttttttc agaggtcatg attttttcag ctacactttt
     3481 atcaagcaca atattgccaa aaaatgaaga acgaatccct tcatgcaata cttcatcaga
     3541 gctatctttt aaaaggtatc ctgaagcacc aaacttcata gcatctttta tatattcatc
     3601 atcattaaaa gttgttaaaa ttaataatgt tatagaatta ttatattcct ttataagcct
     3661 tgtacctaga accccatcac atactttcat tcgtatatcc ataagaacta tgtctacatc
     3721 attcatttta caaaattcta aagcttcata tccattagaa gcatctccta caatttctaa
     3781 atcattataa gatgataata taattttaag accttttcta attaattttt cgtcatctac
     3841 tataagaact ttaattttat tcaaaaaaat caccccctga aaatttagga aaagaagctc
     3901 taattgtgaa accattatta gaattatcaa attcaacttt accatttaat tcatatattc
     3961 tctcattgat actattaagt ccatttcctt tttttatatt gccacatcct ataccattat
     4021 cactaatagt aattataaga tttgaagtat tgaatgtaat aaaaattctg atttcagttg
     4081 cctttccatg catcgatgag ttggaaaggg attcctgtat aagtctatat aaagctatag
     4141 attgatttct ggataagttc caagtatttt ttgaaatagt taatttaaca ttaatatttg
     4201 taagcttaat aaagctttta actaattctt tgattttaaa taaactttgg taattttcat
     4261 attcaacagg ttttaactca gatatagccc ttcttacatc ttgaaaactt tcagttacaa
     4321 attctctaag ttcatgtact aagtcataaa ttagaggttt gtcttttaag agtttttcta
     4381 tagcatttaa ttgtattatt gttgtagaaa gagaatgtcc tacactatca tgtatttctc
     4441 ttgatattcg atttctttct tttaaaattg ctaattcttc tatagaactt gcataagttt
     4501 ccaaatcagc attaactttt tttaattcat ctttagaaat tctaagctta tcataaagat
     4561 tttgactgta taattttgat aaattctcat tttctatata tatagaaagt acagttataa
     4621 ttagcaatat agagcttgac tccagtgcca aatatatatt tttatctaaa ctaataataa
     4681 gagaagatat tataacaaaa gagaacaata tgtacttata tttttccttt attaaaaatg
     4741 atatatctaa tattaaagga acaaagtaaa tcgaattaaa agtttttgta taattacaaa
     4801 gtataaaaat taatataagt tctaaaaagt aagaaataag tataaattta ttctcatttg
     4861 ataaagaaaa aaatctaact tgattattta ttataattag aaataatatt atcatagtta
     4921 tgaccggata caatgtattt tcaacatttt tcaaatagct tacaactaat ataaataaag
     4981 ataaatatcg tataaaagca actaattttt ctctgttcat taaaggcact cctccaaaaa
     5041 aataaacttt tcctatgaaa actagaataa tatcataaaa gaataaagtc aatagaagta
     5101 tttattaata ttgatggaaa taaaatcaat ccaaaaactt gaatagtaaa attgtatact
     5161 gaccataatt taaaagtgaa aatttaatgt attggagtga ataatgaata ataaagaaaa
     5221 aggtgatttt ggagaaaaag tagcagttaa ttatttgcta tcaaaaggag caaagatact
     5281 agaaaaaaat tacagattaa agatagggga aatagatata atagcaaaaa tggaagatga
     5341 aattatattt gtggaggtga aatcaaggtc taacataaag tttggctacc cttgtgaatc
     5401 tgtaagcttc aaaaaaagaa aaaagataat tggagttgca aattattata ttataaaaaa
     5461 taacttaaat aacactccca taagatttga tgttatagag gtatatttat tagaaaaaag
     5521 aataaatcac ataatgaatg ctttttaaaa aagataatgt ttttggaaag gattaaatat
     5581 gttaagtatt attaattcaa gcaacttagt aggaatcgac agctttttag ttaaggttga
     5641 agtagatgta agcaatggaa tacctagttt taatattgtt ggtcttccag gcaaagaaat
     5701 taaagaagca agagaaagag taaagtcagc aattcttaat agtggatata aatttccaag
     5761 cacgagaata gttgtaaatt tatcaccagc agatataaaa aaagaaggag cttttttaga
     5821 tttatctata agtataggcc ttttaagaga gttaataaaa aaagatgaaa attacataag
     5881 agaaagtatg tttataggag aattatcatt agatgggaaa ataagaaaag taagaggtat
     5941 attgcccata attatgggtg caaaaactca gaacataaaa cgtattttta taccaattga
     6001 gaacataaaa gaaagtctat ttgtagatga aattgatata attcctatta aaagtttaaa
     6061 agaatgtgtc gattttttaa acgaagagat aaaagtcgat aaagtaagga taatgtcttt
     6121 tttggatgat aagtcaagaa aagagaacga agaattagaa aaagataata gttatataga
     6181 ttgcaaatat actaagatta ataatgaaga aagtaaatat gatgaagact ttaaagatgt
     6241 aaaaggaaat tattttgtaa agaggagtgc agaaattgct gctgctggaa atcataatat
     6301 gtttatgatt ggacctccag gctcaggaaa aactatgatt gcaaaaagag taaggacaat
     6361 tttaccagat ataagtgtag aagaaatgat agaagtaagt aaggtctata gtatattggg
     6421 tatgataaat gaaactaaag gaataattga taaaagacct tttagagcac ctcatcatac
     6481 aactacaaag caatctttaa ttggaggagg aatggatgca agacctggag aaattgcttt
     6541 agcacataga ggtatcttat ttttagatga gatagccgaa tttgatagaa aaatacttga
     6601 gactttaaga caacctatag aagatggata tgtaaatata tccagagtaa agtacagtgc
     6661 aaaatatcct tgtagagtac tgttagttgc agctatgaat ccatgtccat gtggttatta
     6721 tatgtcagag acagagtgta gatgtagaag taacgaaatt gatagataca taaataaaat
     6781 atcaggtcca ttgttagata ggtttgatat ttttgtagaa gttaattcta taaaatattc
     6841 agattttaat tctttaaaac aagaagaaag ctctcaaaaa ataaagagaa gagtagaaaa
     6901 tgctagaaaa atacagataa atagatttaa gaaagataat ataaaaaata atagtgaaat
     6961 taaagcttac aatttattta aatattgtaa actggaaaaa gaagcttcaa aaacggctga
     7021 gatgatattt agtaaataca acctaagcag tagaagttat acaaaacttt taaaaatggc
     7081 aagaacaata gcagatttag aagaaagaga tttgataaat tcacagtgta ttatagaagc
     7141 tttttcattt agaaaggctt attatagtta ttttaaatag ttttttgagg tggattttat
     7201 ggaaaaaaga gatacttatt tatggttaaa atcaattggt ggaataacaa caaaaacaat
     7261 tgaaataata gaaaatgaaa tagtaaatat tgaagatata tttgattttt ctgaaaaaga
     7321 aatatataat ttaaaaaata taagcttgaa tattagaaaa aatatagtaa aatatagagg
     7381 tcacgcttat ttagaaaata taaaagaact actttacaaa aaagcgatta aatatatttg
     7441 taaatatgat aaagaatatc ctgaaaattt aaagaatata tacaacgctc caaagttatt
     7501 attctacaaa ggtgacatag gcttagttaa taataatttt aatatagcta tagtaggttc
     7561 aagaaaacct acagcctatg gaattaattg tgcaaaaaca ataagttgtc aactatccca
     7621 atatggagtt aatatagtaa gtggattagc tataggaata gatgcatact cgcacatagg
     7681 ttgtatgagt ggaaaatcta aaactatagc agtacttggt tcaggagtag acaatcctct
     7741 tccaaaacaa aatttacatt tatcaaataa aatattagaa aatgggggat tattattatc
     7801 agagtataat attaactcga cagtagcccc gtaccatttt tctaatagaa atagaattat
     7861 cagtggttta agtgatggag tagttgttgt agaagcagca ataaaaagtg gtgcactaat
     7921 cacagtagat tttgctcttg aacatggaaa aaatgttttt gcaatacctg gtaatataaa
     7981 ttctcaaatg agtagaggtt gtcataaaat tataaaagaa ggtgcaaaat taattgaaaa
     8041 tatagatgat attttaaatg aatataacat atttaatatt attgataaaa aaataaatca
     8101 aaaatatgat aatataagtc taaatgccaa gtctaagcaa ataattgaag ctataaaaag
     8161 agaaggaaac ttgcatatag atagtatttg tgattatact ggtatagaaa taaagtatgt
     8221 aaattcaata atcaatgaat tagtactaaa tgagttagta gtagaaatga ataataaaac
     8281 gtacagttta aatgtataaa ttaagattag gtagtggggg tgtatggttt tatggccaaa
     8341 acattagtca tcgtagaatc gcctgcaaaa gctaaaacta tagaaaaatt tttagggaaa
     8401 agtcattaca cagttaaagc atcagttggt catgtcagag atttacctaa aagtaaatta
     8461 ggtgtagata tagaaaataa ttttgaacct caatatataa atataagagg aaaaggcgat
     8521 gtaataaaag aattaaaaaa agaagctaaa aaatctaaac aagtatatct agcaactgac
     8581 cctgatagag aaggtgaagc tatatcatgg catttagctc atatactaaa tttagatgaa
     8641 tctgaggatt gtagaataga gtttaatgag ataactaagg atgcaattaa aaaagcaatt
     8701 aaacatccta gaaatattga tataaatttg gttgatgcac aacaggcaag aagagtgcta
     8761 gacagacttt taggttatca aataagtcct atattatggc aaaaggttag aaaaggtctt
     8821 agtgcaggta gagtgcaatc tgttacaaca aagttaattt gtgatagaga aaaagaaata
     8881 aaggcattta ttccaaaaga atactggaca atagatgttg aggctaagac agtaaaagac
     8941 aaagatataa ctttgaaatt ttatggtaaa aatgatgaaa agattgaatt agaaaatgaa
     9001 gaagctgtaa atgaaatact aaaagaaatg gaaggtaaag atttaaaggt tgagaagata
     9061 gaatctaaat caagacgtaa atcagctcca aaaccattta caacaagtat gcttcaacaa
     9121 gaaggagcaa ataagttatt ttttactact aaaaaaacaa tgatgatagc acaagaatta
     9181 tatgaaggta tcgacataga aggtgaaggt actgttggtc ttatatcata tataagaact
     9241 gactctaaaa gaatatctga tgaagcaaaa gaaaaagcta agggttatat cgtaaacaat
     9301 ttaggagaaa actactataa aaacattggt gataaaaaag aaaaaaagga tactaaaaag
     9361 gttcaagatg cccatgaggc aataagacca acctcagttg atagaactcc tgagagtata
     9421 aaagcctcat tgagcaaaga ccagtacaag ttatacaatt taatttggag aagatttgta
     9481 gctagtcaaa tggaagattc agtgtttgat atactaaatg tagaatgtaa aataggcgat
     9541 attgtattta aggcaactgg ttcaaaaatg aaatttgatg gttataccaa ggtatataat
     9601 ttttcagaaa gagaagacaa aattttacca agtatagaaa aaggagatat attaaatata
     9661 gaaaatatat tgccagacca acattttaca caaccaccag caagatatac agaagctagt
     9721 ttagtaaaaa cactagaaga actaggtata ggtagaccaa gtacgtatgc tccaacaata
     9781 gctactatac tgaatagaga gtatgttgaa aagcaaggaa caagtctatg tccaacagaa
     9841 cttggaataa tagttactga tattttggaa aataatttcc ataaatttat agatgtagat
     9901 tttactgctg atatggaaag taaacttgat gttatagaag aaggcaatac agattggaaa
     9961 aagattgtat cagaatcata tgcaccactt aaagaggcta ttgaagaagc tcttgaaaat
    10021 atagaaaaag taaatatgga tgaagaaact gatgagattt gcgagaactg tggttctaat
    10081 atggttatca aatatggtag atttggaaag tttatggctt gtaaaaacta tcccgattgt
    10141 aaaacaacta gaccaattat gaataaaatt ggtgttaaat gtccaaaatg tgaagaagga
    10201 gatattatac ttagaaaatc taaaagaggt aaagcttttt atgggtgttc taattatcca
    10261 aactgtgact ttgtagcttg gaataagcca acaggagagt tttgtgagaa gtgtggttca
    10321 tatatggttg aaaaagtgac taaatctgaa acaaaaacag tgtgttctaa taaagaatgt
    10381 aataaagaga caaaagagca taatgacgga aaagagtgaa aattgaaaaa aatcacataa
    10441 ttctcttgaa aaaggttcca atctatgata atctttcaag tgtaaacaac taatagaaaa
    10501 ataaattttc attaaatgtg aaaataatat tagaaaatat aaaaggttat taaaaggcct
    10561 aaatttcatg aggagatgat taaatggcaa gtgaagtgtt acaaaaaaca aggaaaataa
    10621 ataaaacatt acaaacaagt ggtggaagca gtgtctcttt tgatttactg gccggagcat
    10681 tgggcgacgt tttaagttct aatgtttatg tagtaagtgc aaaaggtaaa gtactaggtc
    10741 ttcatttaaa tgatgttcaa gacagttcag ttatagaaga tgagtatact aagcaaaaga
    10801 aattttcaga tgaatatact caaaatgtgt taaaaattga tgaaacatta gaaaatttaa
    10861 atggtgagaa gatattagaa atctttcctg aagaacatgg aagattacaa aaatatacta
    10921 cagtagttcc aatattagga agcggtcaaa gattaggaac attggtactt tcaagatatt
    10981 caaattcatt caatgatgat gatttagtaa tagctgaata cagtgcaact gttgttggtc
    11041 ttgaaatatt aagagcaata ggtgaggaat tggaagaaga aatgagaaag aaagctgtag
    11101 ttcaaatggc aataggcact ctgtcctact ccgagcttga agcagttgaa catatttttg
    11161 ctgaattgga tggaaaagaa ggtttacttg tagcaagtaa gatagctgat agagttggta
    11221 taactaggtc tgtaatagta aatgcactta gaaaatttga gagtgcaggt gtgatagaat
    11281 caagatcatt aggtatgaaa ggtactcata taagaatact taatgacaaa cttacagatg
    11341 aattaaaaaa attaaaaaac aatcaataat ctatatttta taggtttaga ttagaaaagg
    11401 tatctatttc aaatagatac cttttttaga cgaattatta aggtaatgat aagtatatta
    11461 aaaaggagtg agaaaatgcc tttagcagat aaaataagac caaaaacaat gaatgatgta
    11521 ataggtcaaa gtcatataat aggtaatgga aaaatattgt ctaagatatt acaatctaat
    11581 tttttaccaa atatgatatt ttttggtcct cctggtgttg gtaaaactac agtagcggaa
    11641 ataatagcag aaagaagcaa taaaagcttc tataaaataa atgctactaa ttcatcttta
    11701 gaagatataa aaaaggtgat atcagagctt ggaagtataa ataatgtaaa tggagtccta
    11761 ttatatatag atgaaataca aagttttaat aaaaaacagc aacaatcaat attagaattt
    11821 atggaaaatg ggagtataac tttgattgct agcactacag aaaatccata tcattatgta
    11881 tataaagctc ttttaagtag gtctactgta tttgaattta aacctttaga aaaacttgat
    11941 atagaaaaag gactgaaaag agctgttgaa gtattaaatg aagatagcta tatggatatt
    12001 gagtgtaata atgatgctat tgaagatata gcaattcttt ctgatggaga tatgagaaga
    12061 gccttaaata ttttggaagt ggtagtctat tcaactaaac caaataagga taatataact
    12121 tatatagatt cagatgtaat aagggcatct acatttaata aaattataaa ctatgacaaa
    12181 aatggtgata gtcattatga tattttaagt gcatttcaaa aatctataag aggaagtgac
    12241 ccacaggcat ctatacacta tctagcaaga cttataaaag gtggggattt gataagtata
    12301 tgtaggagac ttttagtaat agctagtgaa gatataggtt tagcttatcc aaatgctatt
    12361 gtaattgtaa aggcatgtgt agactcagct atgcaacttg gatttccaga agcgaaaata
    12421 ccattagcag aagctactat tcttttggct acatctccaa agtctaattc tgcatgtata
    12481 gcaataatga aagctatgga tgaactggat aaagagtttg ttaaggatat accaaatagt
    12541 ataaaggatg ctcactattc tggttctaaa gaaataggta ggggttgtgg atacaaatat
    12601 cctcataatt ttaaaaatca ttatgtaaag caacagtatt taccagatag cataaaagat
    12661 agtatttatt acataccaca agaaaataaa actgagaaaa atataaaaaa atatttagaa
    12721 tatctaaata gtgattttta gactgaactt tatgtatcgg gggtagatat tatgattata
    12781 aaacttaact caacttatca cagtagagtt atgaaatact taaaaaaaga acctgagtac
    12841 aatttgttta taatagggga tattgaaaga tatggatatg gaaataattt tttaaatata
    12901 tgggcagatg tgggtgaaca tggtgaaata aaggcaatat tacttaaata ttttgaattt
    12961 atgatgtttt attctgatgg agagtatgat gttgaaggtt tttataatct acttcgtaat
    13021 actaattacg aagaaatatc tgggaaaata tgtgctgtag atgctttagc aaagagatta
    13081 ggacttaata atttaaaggt agttgatttt tgcaaacttc aaactaaaaa gtttttgata
    13141 gataataatt gtaatgcaaa ggttaagaga attaggcttg gaaatctaaa aaagacagta
    13201 aaactttatg acttaataga tgaatttcac agtacaactt tagagaattt aaaaaatgga
    13261 ctaaggacag gtagaggata ttgtatagag attaacaaac aggtggtgtc aatggcaaag
    13321 agtacttcag aaaataggac tcatgcaatg ataattggag taggaacaca tcctaaatat
    13381 agagctaaag gacttgctac aaaatgccta attaaactat gttcagagtt actgagagaa
    13441 aacaaaattc cttgtttgtt ttatgataat gaagaggctg gaaagatata taaaaaacta
    13501 ggatttgaaa acattggaaa atggggaatt tattcaaaat aaaaaattaa aattaatctt
    13561 gacaaaatta gtagggtata ataaaattat cttgaaagta attcctacta aaacagtatg
    13621 aattagattt ctatatagag gtgataatat atgaagttgt ctactaaagg tagatatgga
    13681 ctaaaagcaa tgtttgaatt agcattaaat caagacaatg gaccagtatc attaaaattt
    13741 attgctaaga agcaaaaaat atcagatcag tacttagaac aaatattttc atctttaaaa
    13801 aaatcgggtc tagtaaaaag tgtgagaggt gctcaaggag gttatttgct ttcaaagaat
    13861 gctgaagaca taacagtagg agatatactt gtagtattag aaggaccagt tgcattatct
    13921 gactgtgtac tagatgaaga tgtatgtgaa aactcaaaca tgtgtgtaac aaaaatagtt
    13981 tgggaaaaga tgaaaaaggg tatagaagat gttatagatt caattactct taaagatatg
    14041 ataaatgact ataacaaaaa taaattagaa aatgatataa caaatattaa aaaatagatt
    14101 tggagatgaa tgtaatggaa aaaagaagat tgtatatgga ttattctgca acaacaccta
    14161 ttaaaaaaga agtattggat gcaatgatgc catacctaac agattatttt ggtaatgcat
    14221 ctagttttca cacattcgga agagaagcaa aagatgcttt ggataaagca agagaacaag
    14281 tagcagccct tataaatgct gaacctagtg aaatatattt tacagcaggt ggttcagaaa
    14341 gtgataactg gacactagag ggtgtagctt atgctaataa aaacaaaggt aatcatataa
    14401 taacttcaaa aatagagcac catgcaatac ttcatacatg tgaatactta gcaaaacatc
    14461 atggatttga aataacttat ttagatgttg atagcgaagg aaaagtagac ttaaagcaac
    14521 tagaagattc aataaaagat actactatac ttataagtat aatgtttgca aataatgaaa
    14581 taggaactat acagcctatt aaagaaatat ccgaaatagc taaaaaacat aagatattat
    14641 tccacactga tgcagtacaa gctacaggta atattccagt agatgttaaa gaattaggaa
    14701 tagatttgat gagtatgtct tcacataaaa tatatggacc aaaaggtgta ggagctttat
    14761 acataagaaa aggtgtaaga cttcataact ttgtccatgg tggagcacaa gaaaaaagca
    14821 aaagagctgg tacagaaaat atacctgcaa tagttggata tggaaaagca gcagaattag
    14881 ctaaggaaaa tatgcaaaat catgtagaaa ctttaactcg tcttagaaat aagttaatag
    14941 atggtgtgtt agaaagaata ccttacacaa gagtaaatgg tagcttagaa aatagattgc
    15001 caggaaatgc aaactttgca ttccaattta tagaaggtga aggaatactt ttattattag
    15061 atatgttagg aattgctggt tcaagtggtt ctgcatgtac ttctggttca ttagaccctt
    15121 cacatgtact tcttgcaata ggtttaccac atgaaatagc acatggttca ttaagactta
    15181 cagttggaga ttttacaaca gatgatgata tagattatat actagagaac ttaccaaaag
    15241 taatagaaag acttagaagc atgtcaccac tttatgatga tgcgaagaaa caaggtttag
    15301 taaaatagac ataaagataa agcataaaaa atagacataa attgagtagg aggaaaagat
    15361 aatgcaatat agtgataaag ttatggaaca ttttatgaat ccaagaaata tgggagaaat
    15421 tgataatgca agtggtgtag gtgaagttgg aaaccctaca tgtggagata taatgaagat
    15481 atttttagac atagatggag atgtaataaa ggatgttaag tttaaaacat ttggctgtgg
    15541 ttcagctata gcaagttctt ctatggcaac tgaaatgata aaaggaaaaa ctataaaaga
    15601 tgcattagaa cttacaaata aagctgttgc agaagctttg gatggtttac caccagtaaa
    15661 gatgcattgt tcagttttag ctgaacaagc tgtaaaagca gctcttatag attatgctca
    15721 aaagaacaat atccatatac cagaattgga tggatatgtt atagatgatg ctcatgacca
    15781 tgatgttgaa gaagaagaat aaaaataagt gattgtgtta tgagaagttt acaatgatta
    15841 aaaagaagta ctaatgatat aattaggaca taaaaaatag ctgtttttaa aatagctatt
    15901 ttttattgcc taaattaagt attttaactt gatttagagg ttaattagtt aacaaaataa
    15961 tccataagat tcaaataata aagatgatta tttttttaga aaatagaaca agctatattt
    16021 taaataagta caatacttgc tctatatggt ataataataa gtaatgcaaa agatgaggtg
    16081 aaatttgttt atgaataaaa aagtaatgat aggtatgagt ggaggagttg atagctctgt
    16141 agctgcatat cttttaaaac aacaaggata tgatgtcatt ggtgttacta tgaagttgtg
    16201 gcaagatgat gatgttgttg aaattgaagg tggttgttgc tctttatctg ctgttgaaga
    16261 tgctagaagg gtagcaaata aaataggtat accattttat gttttaaatt ttagagaagt
    16321 gtttaaagaa aaagtaatag attattttat agatgaatat ttggaaggaa aaactcctaa
    16381 tccctgtata gcttgtaata aacatataaa atttgatgat ttttataaga aggctagaca
    16441 aataggttgt gattatgtag ctacaggtca ctatgcaaag atagaaaagg atgaaagtac
    16501 aggaagatat ttgctaaaaa aatctgttac agataaaaaa gaccaaactt atgcacttta
    16561 taatcttaca caagagcaac tagagcatac tttattgcca ataggtgact atgaaaaaga
    16621 tagagtaaga gaaattgcta aggaaatggg tatggcagta cacaataagc ctgatagtca
    16681 agaaatttgt tttgttaaag ataatgacta tgcaaattat gtaaaaaaac attctaaaaa
    16741 gcgtattgaa gaaggttttt ttgtagatac taaaggcaat atacttggaa aacataaggg
    16801 tatattatat tatactatag gccaaagaaa agggcttgga attacttttg gaaaaccaat
    16861 gtttgtaata gacataaatc caataaataa taccatagtt cttggagaca atgaagattt
    16921 atttaaaaag gaacttattg ctaaagatgt taactttata tcaatagata cgttagaaga
    16981 acccttaaga gttcaagcca aaataagata ttcagcaaaa ccatcaccag ctactattca
    17041 tagagtagga gaagatacta ttaaaatagt ttttgatgaa gctcaaagag ctattactaa
    17101 aggtcaatct gtagtaatgt atgatggaga tattgtagta ggtggaggta taatcgagaa
    17161 aagtttataa aaacatctaa aaaattaaaa aaataagcaa taaagtatat taagagtaaa
    17221 taaagtttat aaaataaatt tattgtatat gaaaatatag tattgattaa ttttgtaaaa
    17281 tttagtaata taattagtat attaattaaa aaacaaatac agtgataagg aatagtaaaa
    17341 tatttgatgt cttacagaga gagggaaatg ctggaagccc ttagaatatg atatttgaag
    17401 cagcctttta gtagcaatct tgaacaattt atcttttata aagaagattt aagtagagat
    17461 tgacggtagt tacgttatag ctaaggtttt ccgaagatat catactttgt atgataatta
    17521 gggtggtacc gcgattgtcc tcgcccctat aaatttattt atagggacga ggttttttat
    17581 ttaaacgaaa aaataaaatt tattaggagg aacatgatat ggaaaagatg ggattaaatg
    17641 aaataagaag taagttttta gaattttttg agtcaaaagg tcattatgta gcaaatagtt
    17701 attctttagt accaaacaat gataagagtt tgttacttat aaactcaggt atggcacctt
    17761 tgaaaaacta cttttcaggt gtagaagtac ctccaagtgt gagaatgtgt acatctcaaa
    17821 aatgtataag aacaggagat atagaaaatg taggtataac tgcaagacat gctacattct
    17881 ttgaaatgat gggtaatttc tcatttggag attactttaa aagagagtca ataaaatggg
    17941 gatgggaatt tgttacagaa tggctaaata taccagaaga taagatatgg gtgactgtat
    18001 atgaagaaga tgatgattct tatgatatat gggcaaaaga aatgaatttc ccagaagaaa
    18061 gaatggttag acttggaaaa gatgataatt tctgggaaat aggtacaggt ccttgtggtc
    18121 cttgttcaga aatatatttt gatagaggag aagaatatgg atgtgacaat ccagactgta
    18181 aaccaggctg tgattgtgat aggtgtgcga catgttgcta attgaaaaga ttagccatta
    18241 acgaaccaaa gaaggaggta tcaaataaac ttctttaaat ggttaatagt taatgaactg
    18301 ataacttgat atgtcaaatg atagagtaac gtcttgaagg gcaaccctaa tactccgttt
    18361 ggcttttgta tatgaacaac cttgatacat tagtcaaaag cacggtgaag tcggcagaga
    18421 ttatgtccta aggctctata tgattcgcta tgtcgattga ctaggttcta ctggactgaa
    18481 ccttacttaa agaatctata gagaaacagg aaatggggct agaggtagtc aagcataaat
    18541 atatgccggg ggtctataaa atacctatgg ttagaatgta tcctaaagat actgacgaat
    18601 ctccgaatgt acagctctat acgcagacga catagaaatg tgtcgggatt ccattgagaa
    18661 tcgtctcaga agttgagtaa aattatctgt tatgaaagac tttatactgt tacaggcagt
    18721 atcgttggga cagggttata ggagaaacct aagggtatat attaaaagat agagttatcg
    18781 gaacgtggaa agctaatgac gtggaggcta ttgttcagct tatgatacgg taacaaggaa
    18841 attggaagta tgaattttga atagtagtaa acgacatttg aatccttacg tttatattac
    18901 ctaaaggtaa aatacaaaac gtaaggaggt gatagaacat gaatattgaa caaaaaagac
    18961 ctaaagaaga aatcttaatt gataaagaca tcatagacca aaaaggtact acccaactcg
    19021 gatatggtga caatcataga ggttatgttt caataggtgg taatagatac aaatatacaa
    19081 gaagattaaa agacccattc ctagtgttag atggggaaac tccatacatc tacacactag
    19141 aactggatag taaaataata taacatacaa cctcaaattt atgttataga tttactaaaa
    19201 tattaattta aatagtaaga caaaattcaa aaaccatata acttgtttta acattagtga
    19261 gagtagagtc acagtaccgt tgaagccatg ataataagtg gtggagggat aggctcaagt
    19321 caaatagcaa aagattatta gattaattta aattcattag ggttcacggt atgactaaga
    19381 aagattatat tccttacaca ttatatagaa aggaataaat cgacctaatc aatgtataat
    19441 acggaaacga aggcaatact taataaagat ttaaagccat taaagaaaga tatgctaaga
    19501 tttaacgagt actacaatat gcaacacata tttgataatc tatataagca gagtcagcaa
    19561 ggaagtaaat tcagcaattt atacaatatt atagtaagta acgaaaacat tttgttagct
    19621 tttagaaata ttaaaactaa tgcaggaagc agaacaccag ggattaatag acataatatt
    19681 aaatattgga aagaaaaacc tactgaggaa tatcttcaat atataaagag aagactagaa
    19741 aactacagac ctcaaaaagt ccgtagagtt gaaattccaa aagctaatgg gaaaatgaga
    19801 cctctaggaa taccttgtat agaagataga ctcattcaac aatgtatcaa gcaagttcta
    19861 gaaccaatat gtgaagcaaa gtttcatcca catagttacg gttttagacc gaaccgaagt
    19921 gcagaacatg caatagcata tatgatgaag aaaattaatc ttgaaaagat gtatatggct
    19981 atagacatag acattaaaag attctttgat aatgttaacc atagtaagtt attaaaacag
    20041 atgtggtcaa taggaattag agataagaaa gttttaagca tcataagtca tatgctaaaa
    20101 gctaaagttg aaaatgtagg aataccagat aaaggtgtgc cacaaggagg aattttatct
    20161 cctttactat ccaacatagt gcttaatgaa ttagattggt ggattagtaa tcaatggcaa
    20221 acttttaata caaagtatcc ctatatacat cctagccata aatacagagc attaagaaga
    20281 actaacctaa aggaaatgta tatagtaaga tatgcagatg attttaaaat attgtgtaag
    20341 aatagaaacc aagctaaacg aatctttacg gcaaccaata attggttaaa agaaagatta
    20401 ggactcgaaa taagtgagga aaaatccaag ataacagaca ttagaaactc taattctgaa
    20461 tttttaggtt ttaaactcaa agcttataaa aagaaaaaga aatatgtgat acaatccagc
    20521 atgagcgaca aagcaattaa gcagaatatt aataatataa aagagcaata caacgtaata
    20581 aagcattatc caattaacaa aaatatttat acgcttaatc gaatcattgc agggtcgcat
    20641 aattattata aaatagcaac aaacgtatat cgggacttca cgaatataca atataatctt
    20701 tctaaatgtt ataaaaatcg cttaagtaat ctagttacaa aacaaggtgc agttacacaa
    20761 gaatacttga ataaatacat gcaatacggt atcaaggaaa aatatatagc tgatgcagtt
    20821 atatatcctt taacaggaat caaaacaaca atgccacacg tatttaatca aaaagttaca
    20881 aactatacaa atgaaggacg gcagattata cactcaactt tgggatatat agaccatgaa
    20941 atgttgaatt atatagctaa gaatccaatt ccaaatagaa gtgtggagta caatgataac
    21001 agactttcac ggtattcagc acaacaaggt atttgtcaaa tttccaaacg actcttaaat
    21061 gaggatatgg aatgtcatca tgttatacct agaagcttag gtggtgacga tagatacagg
    21121 aatttgatac tcatacttcc atttgtacat aaattgatac acgcaacaaa acaagaaaca
    21181 attaacttct accttgaaga attagatttg aataagcaag atattaagag agtcaacaat
    21241 taccgtgtga aagttggaaa tgaattaatt taattgattg cctatttgag ggaacgccgt
    21301 atgaggtgaa agtctcacgt acggtgtggg tcgggggaaa agacggagat tacatcaaac
    21361 tcttacctat cgacatattt agaattttgg aaccatgtat ttactcaatt tgatagagat
    21421 gaagaaggaa attatagtct attagaaaac aagaatatag atacaggtat gggtcttgaa
    21481 agaatgggat gtattatgca aggcgtagac actatctttg aagttgatac aattaaatct
    21541 atactagaag cagttgagaa gttaacagga gtaaaatatg gagagaatcc aaaaaatgat
    21601 atatcaataa gaataataac tgaccatata agagctgtaa cattcttagt tagtgatgga
    21661 gtgcttccat caaatgaagg aagaggatat gttcttagaa gactccttag acgtgctgct
    21721 cgtcatggta agttattagg agtaaaagaa ttatttttac agaaactaat agatgaagtt
    21781 ataaaagtaa atgataaagc atatccagtt ttagttgaaa aagaaagtta tattaaaaaa
    21841 gtagttggaa tagaagaaga aaaattcaat gaaactatag accaaggaac agaaatattg
    21901 aactcttata tagaagtatt aaaaaatgaa ggaaagactg tcctaagtgg tcaagaagct
    21961 tttaaactat atgatactta tggcttccct atagacttaa ctaaagaaat attagaagaa
    22021 gaacatctat ctgtagatga agaagctttt aatgaagaaa tggaaaagca aaaagaaaga
    22081 gctagaaatg ctagaggaaa tatggatgga gaaagttgga aggaagaccc tctatcaaaa
    22141 ttagaatcta cagttgacag tacatttaat gggtatagtg aaatttatgg tgaaggaact
    22201 attgaagcta tagttaaaga tgatgagcta gttcaaagtg cagaagaagg cgataaggta
    22261 tctatagtac tagataacac tactttctat cctgaaggtg gaggacaagt tggagattgt
    22321 ggattgataa ctaatgaaaa cttagtttta gaagtattaa atactaaaaa aggtgctaat
    22381 aatagtataa aacatatagg tataataaaa tcaggaagaa taagtaatgg ggacaaagtg
    22441 aagacactcg tagatagaga aactagaatg tcagctgcaa gaaatcacag tgctacacat
    22501 ttacttcata aggcattaag agaagtatta ggagaacatg ttaatcaagc tggttcttta
    22561 gtaactccag aaagacttag atttgatatt actcactttg aagcgatatc aaatgaagaa
    22621 ttaaaagtaa tagaagaaaa agtaaataat gttattttat catctttaga cataaaatgt
    22681 gatattatga atataaagga agctaaagaa aaaggagcta cagcactatt tggtgaaaaa
    22741 tatggtgatg aggtaagagt agtttctatg ggagattatt ctacagaact ttgtggagga
    22801 actcacttga caaatacttc tcaagtagga atgttcaaaa tattatctga aggtggagta
    22861 gcagcaggtg taagaagaat agaagcaata acaggaaaag ctgtttatga atacctaaaa
    22921 gaaagagatg gaattatctc tgaagtttgt gtaaacttaa aatctaaaga agataattta
    22981 attcaaagaa taagttcttt attagaagaa aataaaaact tatctaaaga attgcatgat
    23041 atgaaagcta agatgagttt acaatcagtt gattctattt ttgattctaa agttgaagta
    23101 aatggagtta atttgataac taataaattt gaaggtatgg atatggatac actaagagaa
    23161 acagcagata atctaagaga taagcttggt tctggtgtag tagtacttgc aaatgtagta
    23221 gatgataaag ttaactttgt agttactgcc actaaagatg tattagataa gggaatacat
    23281 tcaggtaata ttgttagaga agttgcaaaa atagctggag gaaaaggtgg aggaagacct
    23341 aatatggcac aagcaggagc tagtgatgta tctaaggttg accaagcttt aagctatgca
    23401 agtgaggtta ttaagacaca agttaaataa cattcactca aggaggtttt tagtttggaa
    23461 aaagatttag actacactat gaaatttgaa ggaataccag aagataggat gagtgtagga
    23521 gatactattg attttgtata taaagcatta gttgaaaaag gatataaccc tataaatcaa
    23581 attatagggt atctcctttc tggtgattct agctatataa ctagtcataa aaatgcaaga
    23641 gctataatta aaaaatttga aagagatgag atacttgaag aagtaatcac gcactatctg
    23701 aatagaaagt aggtcaaata aatgagaaaa aagattatgt cgttgtttgc aatagtcatt
    23761 atgatttttg tatcaactgc tagctatggt tttgctgaag aaaaaggcaa ggtcatattt
    23821 attgatatga ataggaccaa tcttggaagt atgatgaata ttccaatctt gaaaaatgag
    23881 atagaaaaga gaggctatgt agctctcatg aatataagag gggatcaagg tactgatgat
    23941 agaaggtctt atgcaagtat gggtgcagga acaagagcta gtgtaactac tgaagactat
    24001 atcaattttc aaaaagtaga ccaagatact gctaaagctt ttgaagtcgc aacaggtcaa
    24061 aaagctaaag aaataaatga tttaggcatt aatagatcta taaatgaaaa tcttgagtat
    24121 ggagaatatg gagcaaattt agggtcatta ggaaaaactt tatcagaaaa tggtttaaag
    24181 acatctgtaa ttggaaatgc tgatataatt gaaaataatc aattagttaa aaacagaaac
    24241 ttatgtttag tagctatgga ccaatatgga aggattgatt caggtaatat tgataatatt
    24301 aataagaaag attctaaaat gccatttgga atatctacag attatgataa attactagat
    24361 gaaactaaaa aatcctataa aaatagtgat gctatatttg tagaacttgg agatacatat
    24421 agattagata tgtatagatt aaatctaaat gataatactt atgatataat gaagaaaaat
    24481 attgtaaaaa atataaataa atatcttgaa caagtatttt ctatggttgg agaaaatgac
    24541 actgtttata tagcaagtgc atttccaagt gacctagatt ataagaataa gagaagactt
    24601 tctccaataa taaaatttag tggagaaggg aaaggtctac tggaatctgc cacaacaaga
    24661 aaggctggaa ttgttgccaa tttagatgtt ggagtagata tactaggtac atttggtctt
    24721 gaaaataaag agatggtagg tagaagttat actttagtaa ataaagagga caatattagc
    24781 tatctaaaat cactttatga aaggatagtg tctatatctt caataaggtc aactattata
    24841 aatggctttg taggcgtaat atctgcttct tgggtaattg ccatgtttgc gattttcttt
    24901 agaaattata tgccacataa agagcgtgta ttcaaagtac ttaaggagtt tataaaatta
    24961 ggcataataa tgccactatc atttatgtta gctcctttga tgaattttaa aactccaatt
    25021 tcaatatctt tgggaatatt tgcaactacg ctaatattat acttgttagg tagaaaatta
    25081 tttaaggaca atgatataaa gcacatggga ttttttgcaa cacttactat tttagtcata
    25141 gttatagatt ctgtatttgg aacatactta atgcaaaata acataatgag ttatgatgct
    25201 gtcataggag ctaggtacta tggtgtagga aatgaatatg aaggtgtaac tatagcaagt
    25261 gcagtatttg gcttagcagt attattacat tataagaagg tatctaaatt acttgttgta
    25321 attttttcat taataatact tataactagt gcatatcctt caatgggtgc aaatgttggt
    25381 ggagctatat cagaatgtgt agcatatttg ttgtttataa tgcttatata tgacattaaa
    25441 atagatttta agaaagctgt attattagct gtttcagctg tagttgtcgt ttttgcattt
    25501 gcagctttag atatactttc aggtagtgaa tctcatttag gtatgtttgt acagagaatt
    25561 ttcctaaatg gaccaggaga gatattacaa acatttggaa gaaaaattca aatgaatatg
    25621 caactagcac agacaagtgt atgggtaaat attttacttg taggaattgg agtaattgca
    25681 gtgcttatat ttaaaccatc tagacacttt agaaagataa tgaataattt tccaatcttg
    25741 tttaaagggt ttattgcatc tatggttggt tgtataatta cacttttagt taatgattct
    25801 ggaatagttg ctgcatctac agcatctata tatatactta taccactaat aataataagt
    25861 ataaatatga taatatttga aaaaaataac taaaaaaatt tttactgttc atataggatt
    25921 taaataaaaa atgcaatatg attattaatg taaactggat gcttacataa aaaatcatat
    25981 tgcaattttt atgattgatt atgtaaaatt atatgaagca gtaagcctgt gaccttagtt
    26041 atgagaggtt cagaatatgt atttaatcta tagaatataa atagataaag gaggaactat
    26101 gttagatgga agaataatgg gtcttgatgt tggtgataaa actattggag ttgctgtgag
    26161 tgatttgatg ggattaactg cacaaggtgt aaaaacaata aaaagagttg gcaagaaaaa
    26221 agatattgaa gagctaaaag caataataaa agaaaaacaa gtaaataaaa ttgtatcagg
    26281 attaccaaaa aatatgaatg gaactttagg tccacaagga gaaaaagtaa tcaagttttg
    26341 tgaattggta aaagcagaaa caggtattga tgtagagttt tgggatgaga ggctttctac
    26401 agtagcggca gagaggtctt tattagaagc agatgttagt agacaaaaaa gaaaaaaggt
    26461 tatagatatg ttggcagcag taataatttt gcaaggatat ttagatttta aaataaattc
    26521 ataaaagaac tataaaattg aatacttatg atatataata taaataataa aaataaaaat
    26581 aaatttgagg tgaatgacat tatggaagaa aatataataa atttaataga cgaaaatggc
    26641 gttgaaagcc aatttgaaat aatattaaca ttagaagcag aaggaaaaga gtatgcaata
    26701 ttaatgcctt tagatgatga agaagctgaa gaagctttaa tctttagaat tgatgaggat
    26761 gaagaaggtg aaatcttaat acctttggaa agtgatgaag agtatgaaac tgttgtagct
    26821 gtgtatactg ctataatgga agaagaaggt ttaaattacg acgaagatga atcaaatgga
    26881 cttaactaga taagtaatta agtttgtata taaaaatcag atatttatta tatttgcttt
    26941 aattaaacat tattaattgt aaaagcattt atagtatata tctgtttttt tgttttttat
    27001 taaaaatacc aaaaaattta tgaattttgg tgaataatat atcttttatg ggtatatatt
    27061 tatattatga gaataaatta aatttattta aatgtcttga caaaaaatga attatcaatt
    27121 acaatattat ttaataaaga ttatcaattg aaaatagtaa gggtgatgtt atggcaaata
    27181 caatggattt attaaaagac aagttaaaag aaactggttt taagattacg ccacaaagaa
    27241 gagcaatagt tgaaatattg cttaaacatg accattcaca tctaagtagt gaggaaatct
    27301 atgatttagt tagggttgac tgtcctgaaa taggcttagc tactgtatat agaacaatgc
    27361 agctattgga tgaaatagga ttaatatcaa aactaaactt agacgatgga tgtataagat
    27421 atgagattag tctacataaa gaagactgtc ataatcatca tcatcttatt tgtaaaaatt
    27481 gtggaaagat aatggaagct aaagaagacc ttttagacaa tatagaaaaa gagatacaat
    27541 cattgtacaa atttaaaata cttgatcatg atgttaaatt ttatggacta tgtgacgagt
    27601 gtaatggagt aagcgattca gaagaataaa cttctattgc ttaatgtcga tggaagaata
    27661 gtatagaact tttatattct atgctattct tccatttttt attataaacc atctataaaa
    27721 tgcaaatata cagttttcaa gatgcttata gttttaatat tgaaaatata attaatccta
    27781 taagtacaaa aatgaatgat ttttctatga aattactaaa tggtcctcca acagttaaaa
    27841 aacctaaaga aattttcttt tcgcttagcg gataaaaaat tggtattcct tgctttgtaa
    27901 ataaatctcc taaaaacata tgacttgcat aaccaatcgt accataaaaa gataaattat
    27961 taatattagt gattaattct atttgtttta gtaaaaaata tactattata gttgcaaata
    28021 tgctatgaga aaaacttctg tgctttaacc agggaaaaat tgacaacatt agacaaaaaa
    28081 ttgtaaaata tatttcaact tctatgatgt ataagcatat agctaatagt ataaatatta
    28141 atgatagaaa aacttttctt agaaatgtgt gggttagttt tgcctcaata attataattg
    28201 caacaaatgt aattattgcg cttaaataaa aattatcatt tatatttatt gaaataaaga
    28261 aaataataat attaacagca tatataaaaa ttctatatat gtatttggat acattgtttt
    28321 ttagaatgaa atttgagacc atagaattag atttatccaa atcgggtagt acagcaaaag
    28381 tagctgaaac taaaatatca actaaagata taggaatttt aaatattaaa gatgtttgga
    28441 tagctgttaa gattcctatt gcacaatgag ttttaccacg cataaatcct cctaaattat
    28501 ccgatattaa atcatataat atttagagga tatcaaaata aaataggttt gtcaaaataa
    28561 tacgttaaat gtattttaaa tatagcttaa aatatgatac gaattatggt acaataagaa
    28621 taactggtag cgagtgcgtg atttgatatt atttatgatt gtagaacgtg ttaaaaaatt
    28681 aaatagacag aaggagatga tgcaattgtt caaaaagaac accaacaaga taaaggtaat
    28741 ggccttgggt ggacttaacg aagttggaaa aaatatgact gttgttgagt ataaagatga
    28801 aataattgtt atagatgctg gacttagttt tccagaggat gaaatgttag gagtagatat
    28861 agttatacca gatataactt atttagtaaa aaatagggat aaaataaagg gtatatttat
    28921 tacacatgga catgaagacc atataggagc tcttccatat atattaaaga aaataaatgt
    28981 acctgtatat ggggcaagac ttagtatagg tcttatacaa gtaaaactta aagaacataa
    29041 aatgaataat gttaagttaa atgttatagg tcctagacaa gttataaagc ttgataatat
    29101 ggaagtagag tttttgaaaa ataaccatag tataccagat gcttactcta ttgcaataca
    29161 cacagaccaa ggtataatat accacacagg agattttaag attgacttga ctcctattga
    29221 tggagatgtt atggatatgc atagaatctg tgagttgagc aaaaaaggag ttcttttaat
    29281 gctggcagat agtactaatg cagaaaaacc aggatttact atgtctgaaa agactgttgg
    29341 ggtaggtctt gacgaattat ttgcaaaagg aaatggcaga agaattatag ttgctacctt
    29401 tgcatccaac atacacagat tacaacaaat aataaatact gctgaaaagt ttaatagaaa
    29461 agttgctata tcaggtcgct caatggtcaa tgtagttgga gttgcaaaag aattaggata
    29521 cctagatatt tctgatgaca tgcttataga tttaaatgat atatgtaagt atgaagatag
    29581 tgaattagtg ataataacaa ctggttcaca aggtgaacct atgtcagctc ttgctagaat
    29641 ggctttttca gagcacaaaa aagtagaaat aaagagtggc gatttagtta taatatctgc
    29701 tcatccaata ccaggaaatg aaaaattaat atcaagagta atcaatttct tatttgaaaa
    29761 aggagcagaa gtagtataca gtgatatagc tgatatacac gtttctggac atgcctgtca
    29821 agaagaatta aaacttatac atgcattagt tagaccaaag ttttttatgc cagctcatgg
    29881 tgaatataga atgttaaaaa gacatgctga aatagctgaa cagcttggta tggataaaga
    29941 aaatattttt gtcatgcaaa caggagatgt tttagaatta gataaaaatt ctgctaaggt
    30001 agcaaaccgt atacaaacag gaaacatatt agttgatggt ctaggagtag gcgatgtagg
    30061 taatatagtt ttaagggata gaaagcattt atcagaagat ggtcttatga tagttgtagt
    30121 tactatttcc aaggatgagg gtaaggtctt agcaggtcca gatataattt ccagaggatt
    30181 cgtatatgta agagagtcag aagatttaat ggatggagca aaggatataa ttaagaatgt
    30241 tctaaatgaa tgtgaagaga aaaatattaa agaatgggct tatttaaaga ataatattaa
    30301 agaaaaccta aaagaatatt tatatcaaaa aactaaacga aatccaatga tacttcctat
    30361 cataatggaa gtataatata aaaaaactat aaatttgaaa attagacctc ttgtaatttt
    30421 taaagtaata tcaaaaatcc aattgatatt atcttaagaa ttacaagagg tctttttaat
    30481 actcatttta aaaaaatata tattacataa aataccaatt ataacaatct tttattagta
    30541 aaaactactt atatataaat tttactgata ggaggattct tatggatgat gtttcaagac
    30601 aaaatgctat aaaagcttta aaacaaacaa aaatggaaat agcaggagag tatggaatga
    30661 attatgaaga tgcttttgaa ataatagaaa atgcgtctaa taaaggtgtt ttagaaggtt
    30721 actttaaaaa gcttgaaaag aaaaaaaatt taggtcaagg tatatctagg catttagaat
    30781 aaaaaaagtt aaatgtgaga aaataagttt aaataaactt taagaggtga catcgatgaa
    30841 aaaattagct agtactgctt tggctatatt aattgcgctt actcctttaa gcttttcttt
    30901 tgcaaataat aaggaaaatg ctgatgccaa ccaactaaat atatcttcaa aatcagcaat
    30961 tttgatggat gttggtagtg gacaaatttt atatgaaaag gatgctcata aaaagcttcc
    31021 tcctgctagt gtaactaagg taatgactat gctacttata gtagaagctt tggattcagg
    31081 caagattaag cttgatgatg aagttcaagt aagtgaaact gcatctagta tgggtggtag
    31141 tcaaatattc ctagagccag gagaaactca aaaggttgat acattattaa aaggtatagc
    31201 tgttgcttct gcaaatgatg cttgtgttgc tatggctgaa cacttagctg gaagtgttga
    31261 aggatttgtt gatagaatga atgctaaagc aaaagagtta aatatgaatg atactcattt
    31321 tgcaaataca aatggacttc cagttgcaaa ccactataca tctgctcatg atatagcttt
    31381 aatgtctaga gaactattaa aacacgaaat gataagtaaa tacttaacta catggatgga
    31441 taaggttgta gtagggaaga aacaagttac agtaggtctt gcaaatacta ataaacttat
    31501 aaagcattat caaggagcaa ctggtgttaa aactggtttt actcaagaag caaaatactg
    31561 tttatcagca tctgcaaaga gaggtaatac tcatctagtt gctgcaactt taggagcaga
    31621 gacttctcca gaaagattta atgatgcctc tagcctttta aattatggat ttgctaatta
    31681 tgaaagtgtt aagttatgta gtaaaggtga taatatagca acacttacat tggataaggc
    31741 tgatgaaaac aaagttaaat tggttgctaa agaagattta aatgctctta ttaaaaaagg
    31801 aagttctaaa gaatttgaga agaaaattga aatagtaaaa aatcctaaga tgccaattaa
    31861 aaagggaact gttttaggaa aaataaagat atgtaaagat aaaaaagtaa taggcgaagt
    31921 ggaattgata aatactaagg atataaataa ggcaagctat ctacaaatgc ttcaaagaat
    31981 aattgataat atgatataaa taattatcag atgaaatata attataatac acaaagatat
    32041 gattataata cacataaaaa atacccttat gtaattattt gccatagggg tatttttatt
    32101 taccatatag aagtatttta taatcttatg atttttatag aaatatagaa aagtttatgt
    32161 atcttaaaat atcatttgat ttaatatcat atatagggtt gtttaacaat tatctaagta
    32221 aaggcatact accagtaagt ttattcactt tctttttatt cccataaatt gctatcccaa
    32281 aatactgtaa ctcatcttct ggaacactag caatcttttg tgtaaattct tcataaagat
    32341 tgcaactttg tgctacatct gaaaaatcta caacagttaa atcgttaaat tccaaagtat
    32401 ataatttttt acgtaaatct tttattattt ctttgtttcc ttttaaaata ggtacaggaa
    32461 tgtcaataat tcctaagtgg ctattacctg ttttgtcaat tacatctggg ccaacagttt
    32521 ctggggcatg ttttcctagt gtaattccca ttatagctgc tgtattggat ataattccca
    32581 ttggtaaatt ttcgtctatt accatgacac attttgaatt tttagtttcc atttttattt
    32641 ctccttttta ccttatttaa agttgtttga atcatcattt ataaatatat tttgatactg
    32701 ctttggtgta agaccaataa aattcttaaa aaagtttgta aagtgacttt ggtctacaaa
    32761 tcctgtttgt atcgcagcat ctataggttc tacgcctttt tctaaaagct ttttagcttt
    32821 gtttacccgt atattttcta ggtatctata tggtgtaata ccttttaatt tcgtaaaatt
    32881 acgaagtaga gagtacttat tcatacctgc tatagtgctt aattcgtcaa gtactatatg
    32941 ttcagcataa ttattttcta gataatcaca tactgcttga atttctatat ttgtattttc
    33001 caagttagat tgcaaatttg gctctgtatg ttcttcaatt aattgttcaa ttaggaagaa
    33061 aaaaagctct tcctttttaa aatccaattc ttcttccatg attatatagt gtaattcttg
    33121 tagtagaggt actagctcac tgcgaaatat aacaggttga ttaaattttg gtaaataatt
    33181 tttacctgta atttcaaaga cagttttttt cattatttct ggcttaatat taatacatct
    33241 gtaatcaagt actttatcat ctatttgttc acaagtatga ctatcaaaag ggttaaaaag
    33301 tagcaaatct ccagtacttg tggtatactc tttattttta caagataaat atctttgacc
    33361 tttttctata aaaccaatta cataatgttc atgaaaatgg tttgggaatt tttgcattat
    33421 gcctttaaat ctatatgctt caatttttaa ttccctatca aagcatactg tgcgttcttc
    33481 ttgtctcact taggtaacct cctttcatgt tatacaaagt gtaacacata tttttttata
    33541 cttcttgtat aatattgact aagagacaat aatgtcaatt catgtcaata taatattaca
    33601 cttacagtag gtgtaattat tatattttca caatgaatat gatataataa taaaagttat
    33661 aaaataaaaa gcaaatttta attttatgcc tagaagttaa aattattata atgtaaaata
    33721 attttgatta taagctattt aattgttata ataatattaa aaatttaatt taggagatgt
    33781 acattaatgt taagtatgaa tataggagaa atagtagcaa gtttagttgg tatagctatg
    33841 gcaatatcaa tacatgagtt tggccatgct tattcagctc acttattggg agatgataca
    33901 gctaaagctt atggtagaat gacattaaat cctgtaagac atgttgaccc aataggtctt
    33961 ttggctatgt ttatccttaa gatagggtgg gcaaagccag taccagtaaa tccaaataac
    34021 tttaaaaact ataagatagg aaacctgata gtttcacttg caggcgtttt ttgtaatgtt
    34081 ttgactgcta tactgtgtgt aattatcaat aagtatgtgc atatgtatgc tataaataca
    34141 atagctgaat atgtgttttt atatagtatt ggatttgcag cttttaactt acttccgata
    34201 cctccacttg atggatgggg agttatatct acatttgtac catataaatg gaatgaatat
    34261 ttgtataaat ttgaaagcat gagttatata attttattaa ttgctttatt tactggtatg
    34321 tatagaataa tattaacacc aatatatgca gtgttgctaa aaatagtata tttatttgtt
    34381 taatataata aacagattaa agagggattg atatgaagta taatatacaa ttacaagtct
    34441 atgagggacc attagattta ctttatgatt taataacaaa gcataaaata gatataaagg
    34501 atatatccat aatagatata actaagcagt atctaaatta tttgaaaatg ctagataaaa
    34561 tggatttaga gataactagt gaatttataa ctatggcatc aaaactttta gagataaagt
    34621 ctaaatatct gctttataag caaaaagatg aagaagaaga cccaagaata gaacttatgg
    34681 aaaagttaga agaatataga aagtttaagg tagcatcaca agatataaaa gaaaatataa
    34741 cttatgttaa tgagagattt tatagaaata aagaagagat aattattgat gacaatgtgg
    34801 atttagaaga tatatcaata gaagcaataa aaaatatact tccatatata tttaaagtta
    34861 aaacatcaca gatagaaaat gctaatgatg agaaactaga taaaatagta aggaagaaaa
    34921 taatatctgt agaagaaaaa atattatata taagagatat tataaaagag aagattgaag
    34981 ttacttttac aaatattata aaatcatatg aaaatgatga aataatagct acttttttat
    35041 ctatattaga gcttataaaa gaaaaagaaa tagtcgtagt acaagatata ttttttgatg
    35101 atattctaat aagaaaaagt tcggagtgtt aaaatgaaaa gagaagatat aaagtatatt
    35161 atagaatctg ttatgtttgc atatggtgaa ccaataagta taaaagaatt aaactatata
    35221 ataaataaag aactttcatc aaaagaaata gagattatgt taaatttact tattgaggag
    35281 tacagagaac aaaatagagg tattcaaata atcaagttag agaataagta ccaaatgtgt
    35341 acaaataaag actatgcaga atatataaag aagattattg aaccaaagaa aaagaaaagt
    35401 ttgagccaag ctacattaga aactcttact ataattgcct acaaacaacc aataacaaag
    35461 gtagaaatag aggatataag aggagtaaaa tgtgataagg tattacaaac tttgtttgaa
    35521 aatgaactta taagagaagc tggtagattg aataagatag ggaaaccaat aatttataaa
    35581 acaacagatg aatttttaaa gttgttgaat atagaaagtc ttgaagaatt gccacctata
    35641 gaaaattatc aagaagtggc aacaaatgaa taaaaatata aaatcacaat aatttagtat
    35701 gtaattttaa attttaaaag atttaaaatg ctctaa
//
LOCUS       DAEHWM010000034        34750 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.035, whole genome shotgun sequence.
ACCESSION   DAEHWM010000034 DAEHWM010000000
VERSION     DAEHWM010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 34750)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34750)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34750
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.035"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(148..804)
                     /locus_tag="KNP36_001754"
     CDS             complement(148..804)
                     /locus_tag="KNP36_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0873630.1"
                     /translation="MELQDTIFKRQSVRKFKNQDVSDEDILKMIKAAGAAPSGKNIQN
                     WHFVVIKRRDLMEKIADVITKKQQEILVEMDKVSVDKANRFRKFVKNFTLFYLKAPVL
                     VLVFTKVYNPSGYYELELIDAPKETIDKLFIRNPGMQSLGAAIENFTLSAIELGYGSC
                     WLTSQNYAADEIEAVLEAETGFEKGEYFLGAMLALGVPEDNLKSPSKKPVEEICTFIK
                     "
     gene            complement(859..1488)
                     /locus_tag="KNP36_001755"
     CDS             complement(859..1488)
                     /locus_tag="KNP36_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBF0873631.1"
                     /translation="MVDSIIFDLDGTLWDSTEEVCKVWQDVLSEHKEIELSVTKDLFR
                     SLMGLSFEEIANRLFPNLSEEERMNLLNECSLKECDYLSENGAKLFDDIEDTLKLLSK
                     KYKLFIVSNCQAGYIESFLKAHKLEQYFIDFECPGNTGLHKGENNKLIIERNKLINPI
                     YVGDTQGDANSAKFVGIPFIYAKYGFGNVDVYDYFIDSFKDLLEHDILK"
     gene            complement(1619..2260)
                     /locus_tag="KNP36_001756"
     CDS             complement(1619..2260)
                     /locus_tag="KNP36_001756"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HBF0873632.1"
                     /translation="MKICIVLNGEIEDYEVTRDIIIKECYDCIICADGGANHTYKMEI
                     MPDYILGDLDSVEEEKINFYKNKGVKFEKFPSKKDETDTELCLFLAKTLKANHIDFFG
                     ALGGRIDHTLANIKLLYYLKEDGIYSRILSDKEEMYIVENEEISLYGNPGDTISVIAI
                     NGDAKGVTLTGLEYPLDNYYMKYSVPIGISNVMLSNSCKIKVEQGCVLVVRNL"
     gene            complement(2269..2940)
                     /locus_tag="KNP36_001757"
     CDS             complement(2269..2940)
                     /locus_tag="KNP36_001757"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HBF0873633.1"
                     /translation="MIKLAPSILSADFAKLLEDVRKVESAGCEYLHIDVMDGHFVPNI
                     TLGPLVVKSLKKENINMVFDAHLMIENPDQYIEEFVKAGCDIITVHQEACVHLHRTIQ
                     NIKSHGIKAGVVLNPATPVDTIKHVLPDLDMVLLMSVNPGFGGQSFIPCVLDKIKELK
                     AIIDSQGLNIDIEVDGGISPKNVAEVVQAGANVIVAGSAIFGSDDIQETVNLFRKNAS
                     LEELV"
     gene            complement(2945..3829)
                     /gene="rsgA"
                     /locus_tag="KNP36_001758"
     CDS             complement(2945..3829)
                     /gene="rsgA"
                     /locus_tag="KNP36_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HBF0873634.1"
                     /translation="MLEGKIIKGISGFYYVDTYNGIYECKARGIFRKQKITPLVGDRV
                     KISIVDENEKKGILEEIDSRDTELIRPPIANVDKALIVFAIKNPKPNLSLLDRFIVLA
                     EKENLETVIILTKADLDDNDTLETVKNIYELSGYKVIPVSNITKLNIDKVKEELKENV
                     VVFAGPSGVGKSSLLNEIDENFKLQTGVVSDKIKRGKHTTRHAELLKLEFGGMVADTP
                     GFSSLALEDIEEVELKDYFIEFDKFNDCKFGSKCIHENEPNCAIKEAVTNGEISKERY
                     DSYIQLLHEIRQNNSRRY"
     gene            complement(3927..4664)
                     /locus_tag="KNP36_001759"
     CDS             complement(3927..4664)
                     /locus_tag="KNP36_001759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBF0873635.1"
                     /translation="MKKKTVLITGGARGIGKAMSKAFAKEGYNVLVNFNKSENEAKEL
                     YTILNEKNFSVKLFKADISNREDVEDMVDYCIKEFGGLDVLVNNAGVSQDKLFTDITD
                     EDWDNMMNINLKGSFYCSQVALKYMISEKKGNIINISSIWGISGASCEVHYSITKAGI
                     IGMTKALAKEVGPSNIRVNSIAPGVINTDMLSGYNEEDIDALVEETPLMRLGTPEDIA
                     NCAIFLASDKSNFITGQVISPNGGFVI"
     gene            complement(4772..6787)
                     /gene="pknB"
                     /locus_tag="KNP36_001760"
     CDS             complement(4772..6787)
                     /gene="pknB"
                     /locus_tag="KNP36_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HBF0873636.1"
                     /translation="MGDTILGNRYEIIRKIGDGGMAFVYEAKDRLLNRTVALKVLRPE
                     FVDDDEFLTKFKREAEAVASLSHPNIVNVYDVGEDGKVHYIVMEFVDGKNLKEIIQDE
                     GILDEYTALDITKQIAMALSAAHKKGIIHRDIKPHNILISNEGRVVKVADFGIAKAVS
                     NSTMTNIGSIIGSVHYFSPEQAKGKFVTNNADLYSLGIVLYEMLIGKVPFRGDSPISI
                     ALQHINDDIDFTSEEKVRIPQSVRTTIKKLTEKSSADRYQTAEELIEDIEYIEKNIDL
                     DFIKEYDDFATKKIDEKEINKVVNPTLAKPAPEKVVKPVEVADLDDDEDYYDDFYEED
                     DDEDEEEEEIMRAKKNQRPKSTPSKRTKKKKKKQESPKSRRRLKVIAAVLILILCAQV
                     FLAYKFLFAGGFGNKSLTVPNLVNMTLEEAQSAVEKEGLYLSVKSEEYNSEVDENCII
                     SQTPEGGSTNVKKGDTINVVVSKGSSQASVPNVVGLTLSNAKQLIEENNLKVGTVKYE
                     YSSIYKEGTVLSQSPGAGSSRAQEGDEVNLYVSKGSEKSNTQTPTVPDKKPTTPENNT
                     PTEPGSNSGNSGGNSGGSNSGNSGGNSGNNGSNSGGSNSGNSGGNSGGSNSGDNGGSS
                     GGSNSGDNGGSSGGSNSGDNGDSSGGSNSGDNGGTSSGTGANIGKTE"
     gene            complement(6804..7556)
                     /locus_tag="KNP36_001761"
     CDS             complement(6804..7556)
                     /locus_tag="KNP36_001761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HBF0873637.1"
                     /translation="MVYSCASHIGKIRKNNEDYCEGEVIDTEHGPIGIFAIADGMGGH
                     KKGEVASKLAVENIIDFLKENLLQHDNVKIDYIDDILKQAYNNVNSIVHKKSMEDIEF
                     EGMGTTLVTAIVYNNVLYVANVGDSRCYLLTDEKFDKITIDHSVVEELMMAHVITEEE
                     ARRHPQRNRITRAIGTDDMVVVDIFKKEIKKSDIILLATDGLTGFIDDEDIRDLILDY
                     EYERTSNISEELISMANDVSGKDNVSVIVIKV"
     gene            complement(7576..8607)
                     /gene="rlmN"
                     /locus_tag="KNP36_001762"
     CDS             complement(7576..8607)
                     /gene="rlmN"
                     /locus_tag="KNP36_001762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HBF0873638.1"
                     /translation="MEKKKIVLKNFTEDELKEFMKTIDEKPFRGSQIFSWIYKGAKTF
                     DDMNNIPKSLRNKLEEVSCIGHIDIELKLESKVDNTKKYLFLLDDGNIIETVMMDYDS
                     RVTVCVSNQVGCRMGCNFCASTMDGLIRNLEPWEILDQVIKIQEDTGKRVSNLVLMGS
                     GEPLDNFENTKQFLKIINEKNGLNIGYRHITLSTCGIVPKMYELADLEIAINLALSLH
                     SPYDEERRKIMPVANAYSIEEILNACRYYIKKTNRRVTFEYSLIKGVNDSEKEAKALA
                     KLLKGMLCHVNLIPINKVEEREYEKPDKAFIYKFRDSLEKNNIPATVRMSMGSDISGA
                     CGQLRRKYK"
     gene            complement(8615..9940)
                     /gene="rsmB"
                     /locus_tag="KNP36_001763"
     CDS             complement(8615..9940)
                     /gene="rsmB"
                     /locus_tag="KNP36_001763"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HBF0873639.1"
                     /translation="MDAREVGFKVLCDIEKNDNYSNIAINKHFKNLEISDMDRGLATE
                     LIYGVIENKYYLDYIINKLSKIKVKKMSTYVKIFLRMGTYQILFLDSISDYAAVNETV
                     KLSKKYDKKSSGFINAILRNEIRAKETIMDITEEDSVKYLSIKYSYNSWIIKNWIDKF
                     GQEFAEDLLEANNEKPSIYIRTNTLKISREELIEKLSEMGIVCLKVPMVEEAIKVEKM
                     KNIEKNELFKAGLFTIQDISSMIVGKVINPKEGSFVLDVCSAPGGKSTHLATLMNNTG
                     QVVARDIFEHKLKLINSTVNRLGLKNVFVERFDASEIDENSISKFDYVLADVPCSGFG
                     IIRRKPEIKYKKEEELKDITSIQKKILENASKYVKVGGTLVYSTCTIQDVENINIVTS
                     FVEENHNFEFVPIDTVNVDLDNQDKGYLKIYPNIHGIDGFFIAKLKRIR"
     gene            complement(10002..10703)
                     /locus_tag="KNP36_001764"
     CDS             complement(10002..10703)
                     /locus_tag="KNP36_001764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metallopeptidase"
                     /protein_id="HBF0873640.1"
                     /translation="MYPVYGGFWGFDPTMVVLIPAILLTIYAQFKVSSTTNKYLRVNT
                     RRGYTGEQTARRVLDSNGLYDVKIEMVRGHLSDHYDPRRKAVRLSEDVYYGTSITSVA
                     VAAHECGHAIQHAKGYAPLQIRSSLVPVVNFASSISWFLIFLGFIMAGPFLKIGILLF
                     SASVLFQIITLPVEFNASSRAIVQLGNLGIIDESESRQSRRVLSAAALTYVAAALVSI
                     LQLLRLLLIAQRRND"
     gene            complement(10772..11524)
                     /locus_tag="KNP36_001765"
     CDS             complement(10772..11524)
                     /locus_tag="KNP36_001765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF116 domain-containing protein"
                     /protein_id="HBF0873641.1"
                     /translation="MTDIKKYLTSVGILILILGILIGVVNFFIISLTQIFSLMINIII
                     ISLILIILCSTAVTYRVIKGKYVNSNIMKINFNIVSGLFPIISFIASSFGMSKSDIRR
                     IYIKLNNEYIYSNKYNFNPEDIIILIPHCIQENSCKLKVTNDIDNCKECGRCNIGELI
                     KLKEKTNVKIFVATGGTLARKIIMDNKPKAVVAVACERDLTSGIQDIKKIPVLGVFNK
                     RPNGPCVNTNVDIMDIEKAIGFLTGKNILVCN"
     gene            complement(11534..12463)
                     /locus_tag="KNP36_001766"
     CDS             complement(11534..12463)
                     /locus_tag="KNP36_001766"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HBF0873642.1"
                     /translation="MKIVFMGTPDIAVPCLQKIIDEKYEILGVVTQPDKPKGRGKKLG
                     MSPVKELAIENNIPVYQPVKARDKEFIDKIKSLNPDVIVVVAFGQILPKEILEIPKLG
                     CINVHVSLLPKYRGAAPINWVIINGEEKTGVTTMYMDEGLDTGDMILKTEVNLDENIT
                     AGELHDKMMNIGAETLKETLRLIEEGNAPREVQNHEEFSYAPIMNKSLGNIDFSKSAR
                     EIHNLVRGVNPWPSAYTTYNDVIMKVWKTKVLDEKSTKDVGTIIDVSKDGIKVSTIDN
                     VLLIEEIQMPNKKRMLVGEYIKGNTIETGLVLG"
     gene            complement(12478..12918)
                     /gene="def"
                     /locus_tag="KNP36_001767"
     CDS             complement(12478..12918)
                     /gene="def"
                     /locus_tag="KNP36_001767"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HBF0873643.1"
                     /translation="MALRQIVQIGEPVLRKKSKKVEKIDEKIIQLLDDMAETMYDADG
                     VGLAAPQVGILKRVVVIDIGEELIELINPEIIETSGEQIDEEGCLSVVGEAGNVRRPN
                     YVKVRALNRNGETIELEGEELLARAFCHEIDHLDGILFVDKIEK"
     gene            complement(12936..15461)
                     /gene="priA"
                     /locus_tag="KNP36_001768"
     CDS             complement(12936..15461)
                     /gene="priA"
                     /locus_tag="KNP36_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HBF0873644.1"
                     /translation="MNNILNLSRGFIMKKYAKVIVRSNTIYTDNLFTYQIPVFLSDVI
                     KIGHRILVPFGKGNKPTEAFVFQFTDSLDEKIKIKEIIDILDENPIFRKEDLELVYWM
                     KNRYLCTYIECINLIYPKGYKLNNYKVVLLGESLSGLNDIELKEKISTLSDKNREIVE
                     KVIDSKGKIKVDKLKYIPNLNSSLYTMNKNGIIKLCWEYKNHKNEKKVCYISLSLESD
                     KIDDYIEQNKINVGSKQKEILSFLKNNENVEINDLLDLLNASKQSINSLSKKKLITLE
                     FKDYYREPKSIYKSVLKSIKLNNEQQEAVDEIKSNMFVDDKKPYLIHGVTGSGKTEVY
                     MEIIEFALNQGLDSIFLVPEIALTPQTIDRLKSRFGDLVGVFHSKLSEGEKHDVYKAV
                     KAGKVRVLIGARSALFAPFNSLGLIIIDECHESSYKSEKNPKFNAIEVARFMALKNNI
                     TLILGSATPSIEEYYRAKSGEYKLINIKSRANDKPLPNIEVVDMKDELDKGNRSIFSL
                     KLQKEIRYAIEENNQVILFLNRRGYANFVSCRKCGYVFQCENCDISLTYHKKSNTGRC
                     HYCGYEKEIPKECPECKSTYVKPFGVGTQKIEEELKYIFPDIKTLRMDKDTTSKKGAL
                     DEILNKFKDKEADVLIGTQMLSKGLDFENVTLVGILSADMILNFPDFKSFETTFQLIT
                     QVSGRAGRADKEGKVVLQTYDTEHYAIKHAIEYDYEGFYEDEIKIRKAFGYSPFNNML
                     SVVVSGEDERLVIKNIKNMHASLIYLLEKRGINDLGFILGPNPCSISKINQNYRWQIL
                     FKDENIEINLLKGIIKYICITKRDLIFDKNINVSIDINPNSVL"
     gene            complement(15700..16899)
                     /gene="coaBC"
                     /locus_tag="KNP36_001769"
     CDS             complement(15700..16899)
                     /gene="coaBC"
                     /locus_tag="KNP36_001769"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /protein_id="HBF0873645.1"
                     /translation="MLKDKTVVIGISGGIAAYKACDVVSKLKKLNANIHVIMTKSATE
                     FVKPLTFQSLSQNYVVEDMFEEPKTWEVEHISLAKKADLFLIVPASANVIGKIANGIA
                     DDMLTTTVMATKAQVLIAPAMNTNMYENPIVQKNIQTLKSFGYKFIEPESGRLACGDI
                     GTGKLANPDIIVEEVLTNLTKEQDLKGQSMIVTAGPTVESIDPVRYLTNRSSGKMGYS
                     IAREAIARGADVTLISGPTNLSIPQNLKKFVQIESAQDLYEAVVSNLSENKIVIQSAA
                     VADYKPKTYSDKKIKKKNDDLSIELSRNYDIAYEIGKIKEDKILIGFAAETNDLIEHA
                     KGKIKKKNLDFIVANDLTKEGAGFRADTNIVKIIDVEGNITEYPKMKKEEVANVILDK
                     VKALLEK"
     gene            complement(16904..17170)
                     /locus_tag="KNP36_001770"
     CDS             complement(16904..17170)
                     /locus_tag="KNP36_001770"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HBF0873646.1"
                     /translation="MLKPSINEVLEKIDNRYYLVGTVSKRARKLIDGEEPYVSNKTKE
                     KPVCVATKEVASGKITYRLLTEEEIEIEEARHHAEQHQQISEEE"
     gene            complement(17173..17790)
                     /gene="gmk"
                     /locus_tag="KNP36_001771"
     CDS             complement(17173..17790)
                     /gene="gmk"
                     /locus_tag="KNP36_001771"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HBF0873647.1"
                     /translation="MFVKKGLLLVVSGPSGAGKGTICKELLKENDTIKLSVSATTRKP
                     RTGEVDGVNYFFISKEKFEEMIEKGEFLEYAQIYDNFYGTPKAAIMECLEKGQDVLLE
                     IEMQGAKQIKEVCPEGVFIFVLPPSLKELKNRIVGRGTETEAEIEKRFSCAYEEIKMI
                     KDYDYFIFNEDVKTSAKEIEGIISSEKNKVSRYKNIIIEKFKEEL"
     gene            complement(17820..18701)
                     /locus_tag="KNP36_001772"
     CDS             complement(17820..18701)
                     /locus_tag="KNP36_001772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YicC family protein"
                     /protein_id="HBF0873648.1"
                     /translation="MAISMTGFGRGEYKDDNYYFLVECKTINHKYSDINIRLPRKISF
                     LEDKVRNLVKNYVKRGRVDLYIKFDLLGKEDVNLNFDEGLASQYIDILKEIKNKFDII
                     DDISVMNVAKFPDIVKIEEKEEDEDLLWSMLNQAVEDALIKLREMRSEEGKKLAEDIA
                     MRCDLLKNHIEEIEKYSSSVVEDYREKLNLRISELLDDPSIIDENRLAQEVAIYADKS
                     SITEEIVRFKSHIGQLKNTIFKDDSIGRKIDFLIQEMNRETNTIGSKSSDINITNLVV
                     EVKSELEKIREQIQNIE"
     gene            complement(18705..19535)
                     /locus_tag="KNP36_001773"
     CDS             complement(18705..19535)
                     /locus_tag="KNP36_001773"
                     /EC_number="5.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate epimerase"
                     /protein_id="HBF0873649.1"
                     /translation="MKFWKLHGIGNDFIAIDGRFDQINPSDYTALAKKVCHRRFSVGA
                     DGLLVVKDSKVADVEMVYYNSDGSRAAMCGNGLRCFCKFVYDNCIVKKESFTVDTLDG
                     IKDIKVNLTNREINSIRVNMGKGSFIAKDVPVLTNKERFVQESIKVLDRELKVTSMLM
                     GVPHTVVIVDELDVDDVCKYGKEIENNKIFPEKTNVNFVKVEDKYNIHVYTWERGCGY
                     TLGCGTGMTASAIVCNLLNMVESSVNVTSQGGTVKIDVGDFSYMTGPAVKICEGILEV
                     "
     gene            complement(19822..20856)
                     /gene="ltaE"
                     /locus_tag="KNP36_001774"
     CDS             complement(19822..20856)
                     /gene="ltaE"
                     /locus_tag="KNP36_001774"
                     /EC_number="4.1.2.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low-specificity L-threonine aldolase"
                     /protein_id="HBF0873650.1"
                     /translation="MRFIDLRSDTVTMPTDEMREAMAKAPVGDSIFRDDPTVNKLEEL
                     AAAKVGKEDAIFLPSGTFGNQLALFTHCLRGQEIIIGKGYHIVTHEVGAPAVIAGVQL
                     RTIDEDESGALNPELVEKAIRRDDIHEPQTGLICVENAYSGGTVVSLDNLREIKKIAE
                     KHNLPVHLDGARLFNAALTLGVEAKEIAKCCDSVMFCVSKGLAAPMGSILAGNKEFIA
                     KARRKQKVMGGGMRQVGIVAAAGIIAIEKMTLRLNEDHENAKYLACELNKIDGIEVNN
                     VNPDISMVFFKMSEDIIKEDVLIKEFFERNIKINKMENGEYRFVTHVDITKEDLDYVL
                     KTLKELIGVC"
     gene            21152..22927
                     /locus_tag="KNP36_001775"
     CDS             21152..22927
                     /locus_tag="KNP36_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NFACT family protein"
                     /protein_id="HBF0873651.1"
                     /translation="MALDGLVIHSIVDELSSKLTGGKIDKIHQPEDDEVIFNIRNNKE
                     NFRLVLSASASNPRVYLTSNYQKENPLKAPMFCMLLRKYIQGGNIVEISQIGFERIIK
                     ISVESLDELKEKTVKNIMIEIMGRHSNIIITHGEENKIIDSIKRVPFSISRVRQVLPG
                     HDYSLPPEQNKLNPLDDISKDLFIKNLEELEGPIFKSIYSKFLGISPIIAKEICYRAG
                     VNQNAIIKDISDEQFDSLHKVFCNLFNDINSNKYSPCIIIDKKVDKVVDFSCINLTLF
                     SDLSYINKDSMSRILEDFYRTKDIKDRINQRSSDLKKSISVKLDRLYNKLKKQEEELS
                     ESENADIYKIKGELITSYIYMVEKGMESIEVANFYDENCNDVTIELNKNLTPSENAQK
                     YFKKYNKMKHAKVEISHQISLNKEEIDYLENIILSIENCENLAELQDIKEELAKVGYI
                     KTQKKNSKKDTIPSTKPHEFVSSDGFKILVGKNNKQNDYLTLRLADNDDLWMHTKNIP
                     GSHVIIKCAGKEVPDNTVFEGAMLAAFFSKSKLSSQVPVDYTKRKNVKKPSGSKPGMV
                     IYETNSTIYVTPEEETVAKLKVKSE"
     gene            complement(23142..24794)
                     /gene="abc-f"
                     /locus_tag="KNP36_001776"
     CDS             complement(23142..24794)
                     /gene="abc-f"
                     /locus_tag="KNP36_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein"
                     /protein_id="HBF0873652.1"
                     /translation="MLLVKVENLKKYYADKLILDIDKLEILENDKIGLVGSNGQGKTT
                     LLKAILGEIEIDEGYTYLTESYSYISQSENNIETCSHSKEKSLLNAPDKFEEHLSGGE
                     KVKLKIADALSNKKNIIIADEPTSNLDKKSIGVLEDMFKRHEGALLLISHDRRFLDEL
                     CTTILELEDGKLKAYKGNYTDYLMQKDEEVKRADFEYQEYVKEKKRLEKALLYKKALS
                     DGIRKTPKRMGNSEARLHKMGGQTNKKKLDSNVKAIKSRIDKLEVKNKPKVSKEMNIK
                     IQDGMEIISKNLVEVKDMTLKLENKLLLDNVSFKIKRGKKIALLGDNGCGKSTLIKEI
                     LADKNDNIKINNKVKVGYFDQNQSLLDEEKSVLYNTKVNSSFDESFIRINLSLFGFKG
                     DDVYKKVKVLSGGEKVKIALCKIILEDNNFLVFDEPTNYLDIKSMEALEKALINTDKT
                     MLIVSHDRVFVSHICNYIIEIKDAKIREFDCNYDEYTISRNKKTPSRENQIKKENLLV
                     LENRLTTVISMLSIEKDNLKKELYESEYNELLKQINKLKNSF"
     gene            complement(25093..26304)
                     /locus_tag="KNP36_001777"
     CDS             complement(25093..26304)
                     /locus_tag="KNP36_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HBF0873653.1"
                     /translation="MKKTIMSLQHLLAMFGATVLVPILTGFNPSVAIFCAGVGTLIFH
                     FCTEGKVPAFLGSSFAFIPVILAAKEAYGGDLAYAQGGIIVAGLIYIIMSIIVKVVGV
                     NKIKLYFPAQVTGAMIVVIGLNLLPTAFSMASANFVIAFITLAIAILTNKFGRGFIKQ
                     LGILIAVFSGYIICLILRLVDITTITEASLFAIPNFTVPKFSLGAIVIISPVVLAVFM
                     EHIGDMTTNGAVVGKNFIENPGLNRTLLGDGFATIVAGCLGGPANTTYGENTAVLAIT
                     KNYDPSILRRTAIFAILLACVGKFGGFLQSIPGSVMGGISIMLFSMITYVGLKTIRDS
                     SCVESKINILIIAVILLIGLGTTYLSNKGISVGIPITSTVKITGLSLAAIVGIVLNRI
                     LNNQDFKVEEE"
     gene            complement(26588..27121)
                     /gene="pyrR"
                     /locus_tag="KNP36_001778"
     CDS             complement(26588..27121)
                     /gene="pyrR"
                     /locus_tag="KNP36_001778"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001156491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HBF0873654.1"
                     /translation="MVEKAQLMDEKAIARAITRISHEIIERNKGVENLVLVGIKTRGV
                     PIANRISKKIEQIEGTKVDTGDIDITLYRDDLEKIHVEPVVKGTYLDFNVNDKTVVLV
                     DDVLYTGRTVRASLDAIIDIGRPKSIQLAVLVDRGHRELPIRADYVGKNVPTSRHEII
                     SVSLLEIDGEDSVTIKE"
     gene            complement(27481..28428)
                     /locus_tag="KNP36_001779"
     CDS             complement(27481..28428)
                     /locus_tag="KNP36_001779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBF0873655.1"
                     /translation="MFYFLKVKVGDIMDEVKEFLVLEEEEEVRLDIYLAEQLGDMSRS
                     YIQKIIKDGKVKVNNKVEKARYLVKEEDNIVIEIPEPKVLEVLPQDIPIDIVYEDDDV
                     LIINKPQDMVVHPAPGNYENTLVNGILYHCKDKLSSINGVIRPGIVHRIDKDTSGLLM
                     IAKNNYAHNFLAEQLKEHTITREYEFICYGVVKEDKITVDKPIGRNPKDRLKMAVVKD
                     GKNAITHFEVVERFDKFTHMRARLETGRTHQIRVHALSINHPLLGDYVYGPKETKFKL
                     KGQTLHAKKLGFIHPTTKEYIEFNSELPEYFKEVIKKIK"
     gene            complement(28397..28843)
                     /gene="lspA"
                     /locus_tag="KNP36_001780"
     CDS             complement(28397..28843)
                     /gene="lspA"
                     /locus_tag="KNP36_001780"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729400.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HBF0873656.1"
                     /translation="MLYILIIILLIGLDQLSKIWVLNNLVDVSTIPIINNVFHLTYVE
                     NRGAAFGLLQNNQWIFIIVALLATVFGLYYLNTRKVHIFGRLGIILIISGALGNLVDR
                     VRLGFVVDYFDFRVIWEYVFNVADVFVVVGTVFLCIYVLFFESKSR"
     gene            complement(29153..29932)
                     /locus_tag="KNP36_001781"
     CDS             complement(29153..29932)
                     /locus_tag="KNP36_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0873657.1"
                     /translation="MKKIICGICICLLSIVGVYTYNHNTHNQDSSKEAYSLNDNIKDD
                     YEDVIIKKGNEDEKILALTFDDGPDEDFTPQVLDILKKNDVKATFFVVGEKVEYNKEL
                     LKRQYDEGHEIGNHTFTHINVAKNSYSSVEKEITDTQNIIKSVIGVEPKIFRPPYRAM
                     SKSVCDIIVSKGMNIILWSNLDPRDWSNPGVDAIINTILTKVQNGNIILLHDYNTKRN
                     DKSQTIQALEVVIPKLKERGYKFVTVSELIQHLDKNKQVQK"
     gene            complement(29987..30469)
                     /locus_tag="KNP36_001782"
     CDS             complement(29987..30469)
                     /locus_tag="KNP36_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="HBF0873658.1"
                     /translation="MDTKKYKDKLLKERENLTNLVEDMKDNTLFGDTTKHTSEKYSSG
                     ELSSYDNHIGDMGTDLYMQNMQNSLINHEEGRLYQIDLALSKIENGTYGICDLCHNQI
                     DLERLDILPDTSLCNDCAKKENNLLGDAMQNPDVEDSNFYSEDLTNLTDLNKNGILRD
                     "
     gene            complement(30735..32156)
                     /locus_tag="KNP36_001783"
     CDS             complement(30735..32156)
                     /locus_tag="KNP36_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon starvation protein A"
                     /protein_id="HBF0873659.1"
                     /translation="MVSFLGSIVVLIVGYFVYGTFVEKVFGTNDKNQTPAIACRDGVD
                     YVPMKWKRIFLIQFLNIAGLGPIFGAIQGALFGPSAFLWIVFGTIFAGGVHDFASGYL
                     SMKNKGTSASELVGLYLGNGAKIAMRIFSVILLVLVGVVFVTGPAGLLKTLTGVNAQI
                     WVGVIILYYIMATVLPIDKLIGKIYPLFGAALLIMAVGVAGGLIIKGYNIPNINLQNM
                     NPNGTPLFPYLFITIACGAISGFHATQSPLMARCVEKESEARPVFYGSMVAEGIIALV
                     WAAAAMSYFHGIPQLNVIFNDGGAATVVNTVSVGLMGPIGGALAILGVVACPITSGDT
                     AFRSARLTIADAMNYNQDAVKNRFLIALPLFAVGVALTFIDFNIIWRYFSWANQTLAM
                     IMLWTGSAYLVKANKNHYITTLPALFMTVVTFSYIMQAKEGFRLPVNISNGIGVIVAI
                     ILGLLFFKKAKHIKEQNNHKLAS"
     gene            complement(32302..33072)
                     /locus_tag="KNP36_001784"
                     /pseudo
     CDS             complement(32302..33072)
                     /locus_tag="KNP36_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001295458.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
     gene            complement(33077..34279)
                     /locus_tag="KNP36_001785"
     CDS             complement(33077..34279)
                     /locus_tag="KNP36_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBF0873660.1"
                     /translation="MKTSILIALIEKTSLIVVLFLLITKLKIFKQIFQKEEYSFNDLV
                     CIALVFTFLAIFGTYSGINYMGSIVNTRIISIVSGGILFGPMVGITAGVFSGIHRYFM
                     DIGGITSVPCLLSSILAGVLSGFLYKRIPKQHRVMYGILVGMISESFTILLIYLISYP
                     HSLAIQIIGGIYLPLIVGQIGIGFVISIVEGIEKDKKDIEARNKAEIKALQRQINPHF
                     LFNSLNTIASFIRFSPDKARELIINLSTYLRYNLEYSDNLIDINKEIEQVKSFVEIEK
                     ARFGELLTVSYDIEDVNIKIPSLIIQPLVENAIIHGILESGRAGVVKISIKKLPYSLE
                     NTVRISIEDNGIGISEEIINNVYQDNMPENKIGLYNVHLRLKLMYGRGLNIRRIDNGT
                     LIVFYVKE"
BASE COUNT        11066 a         6379 c         3486 g        13819 t
ORIGIN      
        1 aaaaaaagta gttcttattg tattaattaa atcaatgatt tgaaatataa aattaatatc
       61 aataaaacct actttttaat tttttaaata tttattttta atttattttg tttttaattt
      121 acttcgattt taaaatgtcc ttgactttta ttttataaat gtacatattt cttctactgg
      181 ttttttagat ggactcttca aattgtcctc tggcactcca agagctaaca ttgcacctaa
      241 aaaatactct cccttttcaa aaccagtttc tgcttctaaa acagcttcta tctcatctgc
      301 tgcatagttt tgacttgtca accaacaaga accatatcca agttcaattg ctgatagtgt
      361 aaagttttca attgcagcac ctagactctg catacctgga tttcttataa ataatttatc
      421 tatagtctcc ttaggtgcat ctataagctc taattcataa tatcctgatg gattatatac
      481 ctttgtaaaa actaatacta aaactggagc ttttaagtaa aatagtgtaa aatttttaac
      541 aaattttcta aatctattag ccttatccac tgatacttta tccatttcta caagtatttc
      601 ttgttgcttt ttagttatca catctgctat cttttccatt aaatcacggc gttttataac
      661 aacaaaatgc cagttttgaa tattcttgcc tgatggtgct gcacctgctg cttttatcat
      721 ttttaaaata tcttcatctg atacatcttg atttttaaac tttcttacac tttgtctttt
      781 aaaaatagta tcttgtaatt ccatttttaa atccccccat aactttttta ttattttaat
      841 ataattttta aactcatctt attttaatat atcatgttct aacaaatctt taaatgaatc
      901 tataaaataa tcatatacat ctacattccc aaacccatat ttggcatata taaaaggtat
      961 acctacaaac ttagcactat ttgcatcacc ttgcgtatca ccaacataga ttggatttat
     1021 taatttattt ctttcaatta taagtttatt attttctcct ttatgcaaac cagtattacc
     1081 aggacattca aaatctataa aatactgttc tagtttatgt gcttttaaaa aagattctat
     1141 atatccagct tgacaattac ttactataaa taatttatat tttttagata gtaatttaag
     1201 agtatcttct atatcatcaa ataatttagc tccattttca gataaatagt cacattcttt
     1261 caaagaacat tcattcaata aattcattct ttcttcttca cttaaatttg gaaataaacg
     1321 atttgctatt tcctcaaaag aaagccccat aagacttcta aataaatctt ttgtgacact
     1381 taattctatt tccttatgct cacttaaaac atcctgccag actttgcata cttcttcagt
     1441 tgaatcccac aatgttccat ctaaatcaaa aataatacta tctaccacaa aaaatccccc
     1501 ttatgtcaaa gtttattata tatttataat tatatactaa aaagcagata caatcataaa
     1561 tatattttac ttgattgtat ctgctctaca atataaaacc aattgtcaaa atcaaatttt
     1621 ataaatttct aactacaagt acacagcctt gctctacttt aatcttacaa gaattactca
     1681 acataacatt tgatattcca ataggtacag agtatttcat ataataatta tcgagagggt
     1741 attctaagcc agtaagtgtt acacccttag catcaccatt tatagctatt acagaaatag
     1801 tgtcccctgg gtttccatac aatgaaattt cctcattttc aactatatac atctcttctt
     1861 tatcagaaag tatcctagaa tatataccat cttcttttaa ataatataat agctttatat
     1921 ttgcaagagt gtggtcaatc cttcccccta aagcaccaaa aaaatcaata tgatttgctt
     1981 taagtgtctt agctaaaaaa agacaaagct ctgtatcagt ctcatctttt ttagatggaa
     2041 atttttcaaa tttaacacct ttatttttat agaagtttat cttttcttct tctactgaat
     2101 ctaaatctcc taatatataa tctggcatta tttccatttt ataagtgtga tttgcccctc
     2161 catctgcaca tattatgcag tcataacatt ccttaattat aatatctctt gtaacttcgt
     2221 aatcttcaat ttcgccattt aaaacaatac agattttcat tattaaattt aaactaattc
     2281 ttcaagagaa gcattctttc taaataaatt aactgtttct tgaatgtcat cacttccaaa
     2341 tattgcagaa cctgctacta ttacattagc tcctgcttgt acaacttcgg ctacgttttt
     2401 agggcttata ccaccatcaa cttctatatc aatgtttaat ccttgactat ctataatagc
     2461 ttttaactct ttaatcttat ctaaaacaca aggaataaat gattgtcctc caaatccagg
     2521 gttaacagac attaataata ccatatctaa atcaggtagt acatgtttaa tcgtatctac
     2581 tggtgtagct ggattaagta ctacaccagc ttttattcca tgtgatttta tattttgtat
     2641 agttctatgt agatgaacac aagcctcctg gtgaacagtt attatatcac atcctgcttt
     2701 tacaaattct tcaatatact ggtctggatt ttctatcata agatgagcat caaataccat
     2761 atttatattt tctttcttta aacttttgac tacaagtggt cctaatgtaa tgtttggtac
     2821 aaagtgtcca tccattacat cgatatgaag atattcacat cctgcacttt ctacttttct
     2881 tacatcttct aataattttg caaaatctgc tgataatatt gatggtgcta atttaatcat
     2941 gtttctaata cctcctacta ttattttgtc ttatttcatg tagcagctgt atataactat
     3001 catatctttc tttagatatt tctccatttg taacagcttc ttttatagca caattaggtt
     3061 cattttcatg aatacacttt gaaccaaact tacaatcatt aaatttatca aattctataa
     3121 aataatcttt aagttcaact tcctctatat cttcaagggc aagggaacta aaacctggtg
     3181 tatctgcaac cattccacca aattctaatt ttaaaagttc agcgtgacga gtagtatgtt
     3241 ttcccctttt tattttatca cttacaactc ctgtttgaag tttaaaattt tcatctattt
     3301 catttaataa gcttgatttt ccaactccag atggtcctgc aaacactact acattttctt
     3361 ttaattcttc ttttacttta tctatattta acttagtaat attgcttaca ggaatgactt
     3421 tatagccact aagttcatat atatttttaa cagtttctaa tgtatcatta tcatctaaat
     3481 ctgcttttgt aaggattatt acagtttcta aattttcttt ttctgccaaa actataaatc
     3541 tatctaaaag agataagttt ggtttaggat tttttattgc gaatactatt aatgctttat
     3601 ctacatttgc aataggaggt cttataagtt ctgtatctct actgtcgatt tcttctaaga
     3661 tacccttttt ttcattttca tcaacaatgc ttattttgac tctatcacca accaaaggtg
     3721 ttattttctg ctttctaaat atccctctag ccttacattc ataaatacca ttataagtat
     3781 ctacataata aaatccacta atccccttta taatttttcc ttctagcatc aaatgcctcc
     3841 ctttataaaa tttatataaa cacatactgt ttatgagtag tatatcgtgt tattctttcc
     3901 tatttttata taataccaca ttttttttaa ataacaaatc ctccgtttgg actaattacc
     3961 tgaccagtga taaaatttga tttgtctgat gccaagaaaa tagcacaatt tgctatatct
     4021 tctggagttc ctagcctcat tagaggggtt tcttccacaa gagcgtctat atcttcctca
     4081 ttatatccag ataacatgtc agtattaatg acacctggag ctatgctatt tactctaata
     4141 tttgatggtc ctacttcttt agctaatgcc tttgtcatac ctattatgcc tgcttttgtt
     4201 atagaataat gcacttcaca agacgcacct gatatacccc agattgaaga tatattaatt
     4261 atatttcctt ttttttctga tatcatgtat tttaaagcaa cttgtgaaca ataaaagctt
     4321 ccttttaaat taatattcat catattatcc caatcttcat cagttatatc tgtaaacaac
     4381 ttatcttgac ttacaccagc attgtttaca agtacatcca atcctccaaa ttcttttata
     4441 caataatcta ccatatcctc tacatcttct ctatttgaaa tatcagcctt aaaaagtttt
     4501 acagaaaaat ttttttcatt taatatagtg tacaactctt tagcttcatt ttctgactta
     4561 ttaaaattta ctaatacatt gtaaccttct tttgcaaaag ctttagacat agctttacca
     4621 atccctctag ctcctcctgt aattaaaact gttttcttct tcataaatac ttttctcctt
     4681 atattataac caattcagta ttttatacaa aacaaactgc cctttaaaga aaatattttc
     4741 tataaaagga cagctcttat tttattaata tttattctgt tttaccaatg tttgcgccag
     4801 ttcctgatga agttcctcca ttatctcctg agtttgagcc tcctgaacta tctccattgt
     4861 ctcctgagtt tgaacctcct gaacttcctc cattgtctcc tgagtttgag cctcctgaac
     4921 ttcctccatt atctcctgag tttgagcctc ctgagtttcc accactattt cctgagtttg
     4981 aacctcctga gttacttcca ttattgcctg agtttccacc actatttcct gaatttgagc
     5041 ctcctgaatt tccaccactg tttcctgagt ttgaaccagg ttctgttggt gtattattct
     5101 ctggtgttgt tggtttttta tctggtactg ttggagtctg tgtatttgat ttttctgaac
     5161 ctttgcttac atataggttt acctcatcac cttcctgagc tcttgatgag ccagcacccg
     5221 gactctgact taaaactgta ccttctttat atattgagct gtattcatac ttaacagttc
     5281 ccacttttaa gttattttct tcaataagtt gttttgcatt actcaaagta agtcccacta
     5341 cattaggaac agatgcctga cttgaacctt tacttacgac aacatttata gtatcaccct
     5401 ttttgacatt tgtacttcca ccttcaggtg tctgtgatat tatacaattt tcatcaactt
     5461 cactattata ctcttcactt tttacactca ggtataatcc ttctttttca acagcacttt
     5521 gagcttcttc taatgtcata tttacaagat taggaacagt caaagattta ttgccaaacc
     5581 ctccagcaaa taaaaactta tatgctaaga atacttgagc acacaatatc agtatcaaaa
     5641 cagccgcaat tacttttaat cttcttctag attttgggct ttcctgtttt ttcttctttt
     5701 tcttagttct cttacttgga gtactcttag gtctctgatt ctttttagct ctcattatct
     5761 cttcctcttc ttcatcttca tcatcatctt cttcataaaa atcatcatag taatcttcat
     5821 catcatccaa atcagctact tcaacaggct taaccacttt ttcaggagct ggttttgcaa
     5881 gtgttggatt tacaacttta ttaatttctt tttcatcaat tttcttagtt gcaaaatcat
     5941 catattcttt tataaaatct aaatcaatat ttttttctat atactctata tcttctatca
     6001 attcttcagc agtttgatat ctatctgcac tagatttttc tgtaagcttt tttattgtag
     6061 ttcttacact ttgaggaatc ctaacttttt cttctgatgt aaagtctata tcatcattaa
     6121 tgtgttgaag tgctatagaa attggactat ctcccctaaa tggaactttt cctatcaaca
     6181 tttcatataa aactatacct agagaataca ggtcagcatt attagttaca aatttacctt
     6241 tagcttgctc tggtgaaaaa taatgcactg aacctattat actaccaata ttagtcattg
     6301 ttgaatttga aacagctttg gctataccaa aatcagccac ttttactact cttccttcat
     6361 ttgatatgag aatattatga ggttttatat ctctatgtat aatccccttt ttgtgcgctg
     6421 cactaagtgc catagctatt tgttttgtta tatctaatgc agtatattca tctaatatac
     6481 cttcatcttg tataatctct tttagattct tcccatctac aaactccatt acaatgtagt
     6541 gaacttttcc atcttcacca acatcataaa catttactat atttggatgt gaaagacttg
     6601 ctactgcttc tgcctctctt ttaaactttg ttagaaattc atcatcatct acaaattcag
     6661 gtctaagtac tttaagtgca acagtcctgt ttaataatct gtctttagcc tcatatacaa
     6721 aggccattcc tccatcacca atcttcctga tgatttcata tcgatttcct aaaattgtat
     6781 ctcccacaat atcaccgtcc taattatact tttatcacta taaccgaaac attatcttta
     6841 ccagaaacat cattggccat acttatcaat tcttcactta tattactagt tctctcatat
     6901 tcataatcta atattaaatc tcttatatct tcatcatcaa taaacccagt taatccatct
     6961 gtcgcaagaa gtattatatc actttttttg atttctttct taaaaatatc tacaacaacc
     7021 atatcatctg ttccaattgc tctagttatt ctattcctct gtggatgtct tcttgcctct
     7081 tcttctgtaa tgacatgggc catcataagt tcttcaacca cggaatggtc tatagttatt
     7141 ttatcaaatt tttcatctgt taacaaataa catctgctat ctccaacatt tgccacatat
     7201 aagacattat tatacactat agccgtaact aatgtagttc ccattccttc aaattctata
     7261 tcttccatag attttttgtg cacaattgag tttacattat tataagcctg ttttaatata
     7321 tcatctatat agtctatttt tacattatca tgttgtaata agttttcttt tagaaaatca
     7381 attatatttt ctactgctaa tttactggcg acttcacctt ttttatgtcc acccattcca
     7441 tcagctatgg caaatattcc tattggacca tgttctgtat ctataacttc tccctcacaa
     7501 tagtcttcat tgttttttct tatttttcct atatgggagg cacaactata aaccatacga
     7561 cttcctcctt acaaattact tgtattttct tctcaattgc ccacaagctc cactaatatc
     7621 agaacccata gacatcctaa ctgtggcagg tatattgttc ttctccaaac tatccctaaa
     7681 tttataaata aatgctttat ctggtttttc gtattctctt tcttcaactt tatttattgg
     7741 aattaaattt acatgacata gcataccttt taggagctta gctaatgcct ttgcttcttt
     7801 ttctgagtca tttactcctt ttataagaga atattcaaat gtaacccttc tatttgtctt
     7861 ttttatataa tatctacatg cattcaatat ttcttcaata gaataagcat ttgctacagg
     7921 cataattttt cttcgttctt catcatatgg tgaatgaagt gataaagcta aatttatagc
     7981 tatttctaag tctgccaact catacatttt aggtactatt ccacaagttg aaagagttat
     8041 atgtctatac cctatattaa gaccattttt ttcgttaatt atttttaaaa attgttttgt
     8101 attttcaaag ttatcaagtg gctcaccact ccccatcaat acaagatttg ataccctctt
     8161 accagtatct tcttgaattt taataacttg gtctaaaatt tcccatggct ctaagtttct
     8221 aattaatcca tccattgtag atgcacaaaa attacatccc atcctacaac ctacttggtt
     8281 agaaacacag acagtaactc tactatcata atccatcatc acagtttcta ttatatttcc
     8341 atcatctaat aaaaacaaat atttttttgt attatctacc ttagattcta actttaattc
     8401 tatatctata tgccctatac atgaaacctc ttctaattta tttctcaaac tttttggtat
     8461 attgttcata tcatcaaaag tttttgcacc cttatatatc caagagaata tttgacttcc
     8521 tctaaagggc ttttcatcta tagttttcat aaactcttta agttcatctt cagtaaaatt
     8581 ttttaatact atctttttct tttccattct ctcactacct tattctcttt aattttgcta
     8641 tgaaaaaacc atctatacca tgaatattag gatatatctt taaatatcct ttatcttgat
     8701 tgtctaagtc tacatttact gtatcaattg gaacaaattc aaagttgtga ttttcttcaa
     8761 caaaagaagt aactatattt atattctcca catcttgaat tgtacatgta ctatatacta
     8821 aagttccacc aactttgaca tatttagatg cattttctaa aattttcttt tgtatagaag
     8881 tgatgtcttt taactcttct tctttcttat acttaatttc tggtttacgt cttattatac
     8941 caaaaccaga gcaaggaaca tctgctaaaa cataatcaaa tttacttata ctattttcat
     9001 caatctcaga agcatcaaat ctttctacaa acacattttt aagccccaat ctatttacag
     9061 tagagtttat aagctttagt ttatgctcaa aaatatctct agctactact tgaccagtat
     9121 tgttcattaa agtagctaag tgagtagatt tccctccagg agcactacat acatccaaaa
     9181 caaatgaacc ttcttttgga ttaattactt tccctactat catagaactt atatcttgaa
     9241 ttgtaaataa accagcctta aataattcat ttttttctat atttttcatt ttttcgactt
     9301 taatagcttc ttctaccata ggaactttta aacatacaat acccatttca cttaattttt
     9361 caataagttc ttctctactt attttaagtg tattcgttct tatatagata ctaggctttt
     9421 cattatttgc ttccaacaaa tcttcagcaa attcttgtcc aaatttatct atccagtttt
     9481 ttataatcca agagttatag gaatacttta tagataagta ttttacacta tcttcctcag
     9541 ttatgtccat tatagtctct ttagctctta tttcatttct aagaatagca tttatgaaac
     9601 cagaagattt tttatcatat ttcttagata attttacagt ttcattaact gctgcataat
     9661 ctgatatact atctaaaaat aaaatctgat atgttcccat tcttaaaaag attttaacat
     9721 aagttgacat tttttttacc tttatttttg aaagtttatt gattatataa tctaaataat
     9781 atttattttc tattactcca taaattaact ctgttgcaag tcctctatcc atatcactta
     9841 tttctaaatt tttaaaatgc ttatttattg caatatttga ataattgtca tttttttcta
     9901 tatcacataa tactttaaat ccaacttctc ttgcatccat ataaatttct cccttttatt
     9961 aaacataaaa aagggttgtt tctaaacaac ccactttact tttagtcatt tcttctttga
    10021 gctattagta acaatctaag taattgaagt attgaaacca atgctgctgc aacatatgtt
    10081 aaagctgctg ctgaaagtac tcttctactt tgtcttgact cactttcatc tataatccct
    10141 aaattcccaa gttgaacgat tgctctactt gaagcattaa attctacagg caatgttatt
    10201 atttggaata acactgaagc cgaaaacaat agtataccaa tttttaaaaa tggaccagcc
    10261 ataataaatc ctaaaaatat taaaaaccaa gatatacttg aagcaaaatt cactactggt
    10321 actaaactac ttcttatttg aagaggtgca taacctttag catgttgtat ggcatgacca
    10381 cactcatgtg cagctactgc aacagaagtt atagatgttc cataatatac atcttctgac
    10441 aaccttacag cctttcttct tgggtcataa tggtcactta gatgccctct aaccatttct
    10501 atctttacat catacaaacc atttgaatca agtactcttc ttgctgtttg ctctccagta
    10561 tatcctcgac gtgtatttac tcttaaatac ttatttgttg ttgaactcac tttaaattgt
    10621 gcatatatag taagtaatat agctggaatt aatacaacca ttgttgggtc aaatccccaa
    10681 aaaccgccat atacagggta cataaataac actctcctaa aatatatttt tattatacat
    10741 cctcttaata ttcacttcac ttaaaaacag tttaattaca aactaatata ttttttcctg
    10801 ttaaaaagcc tatagctttt tcaatatcca taatgtctac attagtattt acacaaggtc
    10861 cattaggtct tttgttaaat acacctaaaa caggaatttt cttaatatct tgtattccag
    10921 atgtcaaatc tctttcacat gcaacagcta caacagcttt aggtttatta tccattataa
    10981 tttttctagc tagggttcct ccagtagcta caaatatttt tacattagtt ttttccttta
    11041 gcttaattaa ttctcctatg ttgcatcttc cacattcttt acaattatct atatcattag
    11101 taacttttaa tttacaacta ttctcttgaa tacaatgagg tattaaaatt attatatcct
    11161 ctggattaaa attatattta ttactgtata tatattcatt atttaacttt atatatattc
    11221 ttctaatatc actttttgac ataccaaatg atgatgcaat gaaagatata ataggaaata
    11281 atccactgac aatattaaaa tttattttca ttatatttga gttaacatac tttcctttaa
    11341 ttactctata agtaactgct gttgaacata gtattataag tattagtgat attattataa
    11401 tatttatcat caaggagaat atttgagtta aacttattat aaaaaaatta acaactccta
    11461 tcaaaattcc taatattaaa atcaaaatcc caacacttgt taaatacttc tttatatctg
    11521 tcatactttt cacctaaccc aatactaaac cagtttctat agtattccct tttatatatt
    11581 caccaaccaa cattctcttt ttattcggca tctgaatttc ttcaattaaa agtacattat
    11641 ctatagtact tacttttatc ccatctttgc ttacatcaat tattgtacct acatcttttg
    11701 tgcttttttc atctaacact ttagttttcc aaactttcat tatgacatca ttataggtag
    11761 tataggcact tggccatgga tttactcctc taactaaatt gtgtatttct ctggcacttt
    11821 ttgaaaaatc tatgttacct aatgatttat tcattattgg cgcataggaa aattcttcat
    11881 gattttgtac ttctcttgga gcatttcctt cttcaattaa tcttaatgtt tcttttaaag
    11941 tttctgcgcc tatattcatc attttatcat gaagttctcc tgctgttata ttttcatcaa
    12001 gatttacttc tgtctttagt atcatatctc cagtatctag cccttcatcc atatacatag
    12061 ttgtaacacc agtcttttct tcaccattta ttattaccca atttataggt gccgcacctc
    12121 tatattttgg aagtaaagaa acatgaacat ttatacatcc aagtttagga atctctaata
    12181 tttcttttgg aagtatctgt ccaaaagcta caactactat tacatctgga tttaaagatt
    12241 taattttatc tataaattct ttatctctag cctttactgg ttgatataca ggtatattat
    12301 tttcaattgc cagttctttt actggactca tacctagttt tttacctctt ccttttggtt
    12361 tatctggttg agttacaaca cccaatattt catacttctc atctattatt ttttgtaaac
    12421 atggaactgc tatatcagga gttcccataa atactatttt catcaaatca actcctacta
    12481 cttttctatt ttgtcaacaa acaaaattcc atctaagtgg tctatctcat gacaaaatgc
    12541 tctagctaaa agttcttctc cctctaactc tattgtttca ccatttctat ttaaagctct
    12601 gacctttaca taatttggtc ttctaacatt tcccgcttct ccaacaacac ttaaacatcc
    12661 ttcctcatct atttgctccc cagatgtttc tattatttca ggatttataa gttctataag
    12721 ctcttctcca atatctatta ctactactct ttttaatatt ccaacttgag gtgcagccag
    12781 tccaacacca tctgcatcat acatagtttc tgccatatca tctaataatt gtattatctt
    12841 ttcatcaatt ttttcaacct tttttgattt ttttcttaat actggttctc ctatttgaac
    12901 tatttgtctt aaagccatta taattcctcc taaatttata atacactgtt tggattaata
    12961 tctatagata cattgatatt cttatcaaat atcaaatctc gttttgttat acatatatat
    13021 tttattatac cctttaagag attaatttca atattttcat ctttaaagag tatttgccat
    13081 ctataatttt gatttatttt tgatattgaa catggatttg gacctaatat aaatcctaaa
    13141 tcatttatac cccttttttc taataaataa atcaatgatg catgcatatt ttttatattt
    13201 tttatcacta gtctttcatc ttcaccacta acaactacac ttaacatatt attaaaagga
    13261 gaatatccaa atgcttttct tatttttatc tcatcttcat aaaaaccctc ataatcatat
    13321 tcaatagcat gcttaatagc atagtgttca gtgtcataag tctgaagtac tacttttccc
    13381 tctttatcag ctctccctgc tcttccagag acttgagtta tcaattgaaa tgtagtttca
    13441 aaacttttaa agtctggaaa atttaatatc atgtctgcag acaaaatacc tactaaagtt
    13501 acattctcaa aatccagccc tttacttaac atctgtgttc caataagtac atctgcttct
    13561 ttatctttaa atttatttag tatctcatct aaagcacctt tttttgaagt tgtatcttta
    13621 tccattctca aagtttttat atctggaaaa atatatttta attcctcttc aattttttga
    13681 gttccaactc caaatggctt aacataagta cttttacatt caggacactc ttttggaatt
    13741 tctttctcat atccacaata gtggcatctt ccagtattgc ttttcttatg ataagttaaa
    13801 gatatatcac aattttcaca ttgaaacaca tatccacact ttctacaaga tacaaaattt
    13861 gcataacctc ttctgtttaa aaatagtatt acttgattat tttcttcaat cgcataacgt
    13921 atttcttttt gtaatttcaa actaaatata cttctatttc ctttatctaa ctcatctttc
    13981 atgtctacca cttcaatgtt tggaagaggc ttatcatttg ctctactttt tatatttata
    14041 agtttgtatt ctccagattt tgccctataa tactcttcaa ttgagggcgt tgctgaacct
    14101 aaaataagag ttatattatt ttttaatgcc ataaatctag caacttctat agcattaaat
    14161 tttggattct tctcagactt atatgatgac tcatgacatt catcaattat tattaagcct
    14221 aaggaattaa aaggtgcaaa taaagctgac ctagctccaa ttaacactct tactttacct
    14281 gctttgacag ctttgtaaac atcatgtttt tctccttcag atagtttact gtggaacact
    14341 ccaaccaaat ctccaaacct actctttagc ctatctattg tttgaggagt taatgctatc
    14401 tcaggtacta agaatatact gtctaagcct tgatttagag caaattctat tatttccatg
    14461 taaacttcag tttttccact tccagttact ccatgaatta agtatggttt tttatcatct
    14521 acaaacatat tcgactttat ctcatcaact gcttcttgtt gctcattgtt taattttata
    14581 ctttttagta cggatttgta aatacttttt ggctctctat aataatcctt aaattctagg
    14641 gttattagct ttttcttact tagagaattt atactttgtt ttgaagcatt taataaatcc
    14701 aataaatcat ttatctctac attttcatta tttttaagaa aacttaatat ctctttttgt
    14761 ttacttccca catttatttt attttgctct atataatcgt caatcttatc actttctaaa
    14821 ctcaaagata tataacatac cttcttttca tttttgtgat ttttatattc ccaacataat
    14881 tttataattc cattcttatt cattgtgtac aaagaactat ttaagtttgg tatatatttt
    14941 aacttatcaa ccttaatttt acctttacta tcaatcactt tctctactat ttctctattt
    15001 ttatcactta aagttgatat tttttccttc aattcaatat catttaatcc acttaaactt
    15061 tcacctaata ggactacttt ataattattt aatttgtatc cctttggata tatcaaattt
    15121 atacattcta tataagtaca caaatatcta tttttcatcc aataaaccaa ctctaaatct
    15181 tcttttctaa atatcggatt ttcatctaat atatcaataa tttcttttat ttttattttt
    15241 tcatctaagc tatctgtaaa ttgaaataca aaggcttctg ttggtttatt accttttcca
    15301 aatggtacta atattctgtg cccaattttt attacatcag ataaaaatac aggaatttga
    15361 tatgtaaata aattatctgt atatatagta ttacttctaa ctattacctt tgcatatttt
    15421 ttcattataa aacctctact taaatttaat atattgttca tattttaata tactttacaa
    15481 gatattaaaa tctcagaatt tataagcaat ttcaagttat taatattaac tttattttaa
    15541 taattaacta ttaattatat tttatacttt atgacaaaat aaatgctgaa aactacaatt
    15601 taactgacat ttgcgagttt ttactcgcta aaattaaatt gcagctttca gccactttag
    15661 ctgtgataaa atacacaaat atcatattta aaaaaggtct tatttctcaa gcaacgcttt
    15721 aactttatct aaaataacat tggctacttc ttcttttttc atcttaggat actcagtaat
    15781 atttccctct acatctatta tttttacaat attagtatca gctctaaaac cagcaccttc
    15841 tttagttaaa tcatttgcca caataaaatc taaatttttc ttttttattt ttcctttggc
    15901 atgttctata aggtcattag tttcagctgc aaatccaatt agtatcttat cttcttttat
    15961 ttttcctatt tcataagcaa tatcataatt tctacttagt tctattgata aatcatcatt
    16021 cttcttttta atttttttgt cagaataagt ttttggttta taatctgcaa ctgctgcact
    16081 ttgaattact attttatttt cacttaaatt tgatactact gcttcataca aatcttgtgc
    16141 tgactctatt tgaacaaatt ttttaagatt ttgtggaata gaaagatttg taggacctga
    16201 tattaatgtt acatcagcac ctctagctat agcttctctt gctatagaat atcccatttt
    16261 accagaagac ctattagtta aatatcttac tgggtctata ctctctacag ttggaccagc
    16321 tgtaactatc atactttgac cttttaaatc ttgctcttta gtaagattag tcaaaacttc
    16381 ctctactatt atatctggat tagctagttt acctgttcca atatctccac atgcaagcct
    16441 tccactttcc ggttcaataa atttatatcc aaagctcttt aaagtttgta tatttttttg
    16501 aacaattgga ttttcataca tattagtatt catagctggt gctataagaa cctgtgcttt
    16561 tgttgccata acagtagttg tcaacatatc gtcagctata ccatttgcaa tcttgcctat
    16621 aacatttgca cttgctggca ctattaagaa taaatctgct ttttttgcta atgatatatg
    16681 ttcaacttcc caagtttttg gttcttcaaa catatcttct actacataat tttgactcag
    16741 cgattgaaat gtaagtggtt taacaaattc tgttgctgat tttgtcatta taacatggat
    16801 atttgcattt agttttttta acttacttac aacatcacaa gccttatatg cagctatacc
    16861 gccacttatg ccaattacaa cagttttatc ttttagcatg accttactcc tcttctgaaa
    16921 tttgttggtg ttgctcagca tgatgtctag cttcttctat ctctatttcc tcttctgtca
    16981 ataatctata tgttattttt ccacttgcaa cttctttagt tgctacacat acaggctttt
    17041 ccttagtttt atttgaaaca tatggttctt ctccatcaat taattttctt gctctctttg
    17101 aaacagtccc tactaaatag tatctgttgt ctattttttc tagtacctca ttgatagatg
    17161 gttttaacat aattataatt cctccttaaa tttctctatt ataatatttt tatatctgct
    17221 aactttattc ttttcagatg atattatacc ttctatttct ttagcagatg tttttacatc
    17281 ttcattaaat ataaaataat cataatcctt aatcatttta atttcttcat atgcacagct
    17341 aaatctcttc tctatttcag cttctgtttc tgtacctctt ccaacaattc tattttttaa
    17401 ttctttaagt gatggtggta gtacaaatat aaatactccc tctgggcaaa cttcttttat
    17461 ttgttttgct ccttgcattt caatctccag taatacatct tgtccttttt ctaaacattc
    17521 cattattgcc gcttttggag ttccataaaa attatcataa atttgagcat actccaaaaa
    17581 ctcacctttt tctatcatct cttcaaactt ttccttactt atgaagaaat aatttactcc
    17641 atcaacttct ccagttctgg gttttcttgt agtagctgat acagaaagtt ttattgtatc
    17701 attttcttta agtagttctt tgcaaatagt accttttcct gcacctgatg gtcctgatac
    17761 aactagcaat aatccttttt tcacaaacat ttaagcattc cccttctaat attgtattct
    17821 tactctatat tttgtatttg ttctcttatt ttttccaatt cgctttttac ttctactact
    17881 aaattagtta tatttatatc agatgacttc gaacctatag tgttagtttc tctattcatc
    17941 tcttgtatta agaaatctat ttttctacct atagagtcgt ctttaaatat agtattttta
    18001 agttgcccta tatgactttt aaatctaact atttcttctg ttatactgct tttatctgca
    18061 tatattgcaa cttcttgtgc taatctattc tcatctatta tacttgggtc atccagtaat
    18121 tcacttattc tcaaattcaa tttttctcta taatcttcta caacactact tgaatatttt
    18181 tcaatctctt ctatatgatt ttttaataaa tcacatctca tggcaatatc ttcagctaat
    18241 tttttacctt cttcacttct catttctctt aatttgatta atgcatcttc aactgcttga
    18301 ttcaacattg accacaataa atcttcatct tcttcctttt cttctatttt cacaatatca
    18361 ggaaactttg caacattcat aacgctaata tcatctataa tatcaaattt attttttatt
    18421 tcttttagta tgtctatata ctgagatgct aatccctcat caaaatttaa gtttacatct
    18481 tctttgccta ataagtcaaa ctttatgtat aaatctactc ttcctctttt tacataattt
    18541 tttactaaat ttctaacttt atcctctaaa aatgaaattt ttcttggaag acgtatgttt
    18601 atatctgaat acttatgatt tatcgtttta cactctacta aaaagtaata attatcatcc
    18661 ttgtattctc ctcttccaaa accagtcata cttatagcca ttaattaaac ctccaaaata
    18721 ccttcacata tttttactgc tggacctgtc atataagaga aatctcctac atctatttta
    18781 actgttccac cttgagacgt tacatttaca ctactttcta ccatattaag taaattgcac
    18841 actattgctg atgcagtcat accagtacca caacctaaag tatatccaca acctctttcc
    18901 caagtataaa catgtatatt atacttatct tctaccttta caaaatttac attcgttttt
    18961 tcaggaaata ttttattatt ttcaatctct tttccatatt tacaaacatc atctacatct
    19021 aattcatcta ctataactac tgtatgagga acccccatca acatagaagt aactttaagc
    19081 tccctatcta aaacctttat actttcttgc acaaaacgtt ctttatttgt aagtacagga
    19141 acgtccttag ctataaaact tccttttccc atattgactc ttatagagtt tatttctcta
    19201 ttagtaagat ttacttttat atcttttata ccatctaatg tatctactgt aaaactttct
    19261 tttttaacta tacaattatc ataaacaaat ttacaaaaac atctaaggcc atttccacac
    19321 atagctgctc ttgaaccatc agaattataa tataccattt ctacatctgc aacttttgaa
    19381 tctttcacaa ctaacaatcc atccgctcct acagaaaatc ttctatggca tacttttttt
    19441 gctaaagcag tataatcaga tggatttatc tggtcgaatc ttccatctat tgctataaaa
    19501 tcatttccta ttccatgtag tttccaaaat ttcataagta tcgctccttc gtaaattaac
    19561 acttaaacta ttataacata aaaaaattcc cataaactta taatttatgg gaaaagtttt
    19621 gtaatgacaa ctataatttg aggatgtgag ggagagttgc cattacaatt agggtaatta
    19681 tattatgttt ttaagctagt tctttctatg tttatatatt aatatttcta tatgaatttt
    19741 atgtatgttt tatttaaact gtctatgaat tttttaatta aacatctggt aactagctat
    19801 aatccttcta gtagatatct attaacatac acctattaat tctttaagtg tttttaaaac
    19861 atagtctaaa tcttccttag taatatctac atgagttaca aatctatatt caccattttc
    19921 cattttatta atttttatat ttctttcaaa aaattctttt attaaaacat cctcttttat
    19981 aatatcttca ctcatcttaa aaaataccat acttatatct ggattaacat tgtttacttc
    20041 aatgccatca attttattta attcacaagc taaatatttt gcattttcat ggtcttcatt
    20101 caatcttaaa gtcatttttt caatggcaat tataccagct gctgcaacta tacctacttg
    20161 tctcattcct ccacccataa ctttttgctt tcttctagct tttgctataa attctttatt
    20221 tccagcaagt atagaaccca ttggtgcagc taaacctttt gacacacaga acataacact
    20281 atcacaacac tttgctattt ctttagcttc tacacccaaa gttaatgctg cgttaaataa
    20341 tcttgctcca tctaaatgta ctggtaagtt atgtttctca gctatttttt taatttctct
    20401 taaattatca agactcacaa ctgttccacc tgaatatgca ttttctacac atataagccc
    20461 tgtctgtggt tcatgtatgt catctcttct aattgccttt tcaacaagtt caggatttag
    20521 agctccactt tcgtcttcat ctatagttct aagctgaact ccagctatta cagcaggtgc
    20581 cccaacctca tgagtcacaa tgtgataacc tttaccaata attatttctt gccctcttag
    20641 gcaatgagta aatagagcta attgattccc aaaagttcca cttggaagga aaatagcatc
    20701 ttcttttcca actttagctg ctgctaattc ttcaagttta tttacagtag ggtcatctct
    20761 aaagattgaa tctccaacag gagcctttgc catagcttct ctcatttcgt cagtaggcat
    20821 agtaacagta tcacttctta aatcgataaa tctcattttt tcaaccttct ttcatattta
    20881 tatactatag aaccttaaaa ttgatttttt ctgtaaagtt catatacttt catagcttat
    20941 actctacaca ataattatac tatatttact ttatatttaa tctactttaa attattaatt
    21001 ttaaaaataa agtttcctct ctaataaata taaataatta tacaatttaa atattaatct
    21061 ctattgttta aattccccct agtcacaaag cgtatattat gtgtataatt aatttactga
    21121 ctcattttgg tcaaagaaag gggtgctata aatggcatta gatggattag ttatacattc
    21181 aatagtcgat gaattatcat caaaacttac aggtggaaaa atagataaga tacatcaacc
    21241 tgaagatgat gaggtaattt ttaatataag aaataataaa gaaaatttta gattggtttt
    21301 aagtgcaagt gcctcaaatc ctagagttta tcttacaagt aattatcaaa aagaaaaccc
    21361 tctaaaagcg cctatgtttt gtatgttact tagaaaatac atacaaggtg gaaatatagt
    21421 agaaatttct caaataggtt ttgaaagaat aataaaaata agtgttgaat ctttagatga
    21481 attaaaagaa aagacagtta aaaatattat gattgaaatt atgggaagac atagcaacat
    21541 aataataact catggtgaag aaaataaaat tatagattct ataaaaagag tcccttttag
    21601 cataagtaga gttcgtcaag ttttacctgg tcatgattat tcattgccac cagaacaaaa
    21661 caaactcaac cctcttgatg atatatctaa ggatttgttt attaaaaacc tagaggaatt
    21721 ggaaggacct atctttaagt ctatatattc taaatttcta ggtataagcc ctattatagc
    21781 taaagaaatt tgctacagag caggtgtaaa tcaaaatgct atcataaagg atatatctga
    21841 tgaacaattt gattctttac acaaagtatt ttgtaattta ttcaatgata taaattctaa
    21901 caaatactct ccttgcatta ttatagataa aaaggtggat aaggtagttg atttcagttg
    21961 tataaacctt acattattta gcgatttatc atatataaat aaggatagta tgtctcgtat
    22021 tctggaagat ttctatagaa ctaaggatat taaagataga attaatcaac gttcatctga
    22081 tttaaagaag agtatatctg ttaagcttga tagactttat aataaactta aaaaacaaga
    22141 agaagaatta tcagaatccg aaaatgcaga catttataag ataaaaggag aattgattac
    22201 ttcatatatt tatatggtag aaaaaggtat ggaaagtatt gaagttgcta acttctatga
    22261 tgaaaattgt aatgatgtaa caatagaatt aaataaaaac ttgacaccat ctgaaaatgc
    22321 tcaaaaatac tttaaaaagt ataacaaaat gaaacatgct aaagtcgaga tatctcatca
    22381 aatttcctta aataaggaag aaatagatta cttagaaaac ataattttaa gtattgaaaa
    22441 ctgtgaaaat ttagctgaat tacaagatat aaaagaagaa cttgctaagg ttggatacat
    22501 caagactcaa aagaaaaaca gtaaaaagga tactatccca tctacaaaac ctcatgaatt
    22561 tgtttcttct gatggattta aaatattggt tggtaaaaac aataagcaaa atgactatct
    22621 tacactaaga cttgctgata atgatgactt atggatgcat acaaagaata ttcctggttc
    22681 tcatgtaata ataaagtgtg ctggtaagga agtccctgat aatactgtat ttgaaggagc
    22741 tatgctagca gcattcttta gtaagtcaaa actttcttct caggtgcctg tagactatac
    22801 taagagaaaa aatgtgaaaa aacctagtgg ttctaaacca ggtatggtta tttatgaaac
    22861 taacagtact atttatgtta ctcctgaaga agaaacagta gccaagctta aggttaaatc
    22921 tgaataaatt ctgcactaaa tacaaaataa atgttagaca actacacatt atcattctaa
    22981 ataaaaatag tggccttctt ataaagtaca ataataaggc cactttctaa ttagcttact
    23041 tttaattttc taacaaaata cttttctgtt ttaataacta tacttatatt cccaacaaat
    23101 attttcagtc ttcttatata gatgtaatta aaaagttaac actaaaagct attttttaat
    23161 ttattgattt gttttagtaa ttcattatat tctgattcat acaattcttt ttttagatta
    23221 tctttttcta tagataacat agatataaca gttgtaagtc tattttctaa tactagaaga
    23281 ttttcttttt tgatttggtt ttctctacta ggagtttttt tatttctgct aattgtatat
    23341 tcgtcataat tacaatcaaa ctcccttatt ttagcatctt ttatctctat aatatagtta
    23401 caaatatgtg atacaaatac tctatcatga gacactataa gcatagtttt atcagtattt
    23461 atcagtgcct tttccagtgc ttccatagat tttatatcta agtaatttgt tggttcatca
    23521 aatactaaaa aattattatc ttccaatatt attttacata gtgctatttt taccttttct
    23581 ccaccactaa gtacttttac ttttttgtag acatcatcac ctttaaaccc aaataggctt
    23641 aagtttatcc ttataaaaga ttcatcaaat gaactattaa ctttagtatt gtatagaaca
    23701 ctcttttcct catctaataa actttgattt tggtcaaaat aacctacttt taccttgtta
    23761 tttattttta tattgtcatt tttatcagcc aatatttctt ttatcagagt actttttcca
    23821 cacccattat cacctaataa tgctatcttt ttacctcttt ttatcttaaa ggaaacatta
    23881 tctaacagga gcttattttc taactttaga gtcatatctt ttacctctac tagattttta
    23941 ctaattatct ccataccatc ttgaatctta atgttcattt ctttagaaac tttaggttta
    24001 ttctttacct caagtttatc aattctgctt tttatagcct tcacatttga gtccaacttt
    24061 ttcttattag tctgaccacc cattttgtgc aacctagctt ctgaattacc cattcttttt
    24121 ggtgtttttc ttatgccatc acttaaagct tttttatata aaagagcttt ttcaagcctt
    24181 tttttctctt taacatattc ttgatactca aaatcagctc tttttacttc ttcatctttt
    24241 tgcattaaat aatcagtgta attgcctttg taagctttta gttttccatc ttctagttct
    24301 aatatagttg tacataactc atccagaaaa cgtctatcat gagatattaa taataatgct
    24361 ccctcatgcc ttttaaacat atcttccaaa accccaatgc tttttttatc taagtttgaa
    24421 gttggctcat cagctattat gatatttttc ttattactca gcgcatctgc tatttttaac
    24481 ttaacctttt cccctcctga taagtgttct tcaaatttat ctggagcatt taaaagactc
    24541 ttctccttac tatgactaca tgtttcaata ttattttcac tctgacttat ataagaatag
    24601 ctttctgtaa ggtaagtata tccttcatca atttctattt ctcccaatat tgcttttaat
    24661 aatgttgttt ttccttgacc atttgaacca actagaccta ttttgtcatt ttctaatatt
    24721 tcaagtttat ctatatccaa aattaattta tctgcataat atttctttaa attctctact
    24781 tttactaaca acataaaaaa tccctcctta acacacttaa atataaggag agattctata
    24841 aataggcata acaaataaac gtatagacta taatctactc tccttaattt aagcattgca
    24901 aataaagcca ccaaaatagg cttttcaaaa attacaatac tttaaattat aaaaaataga
    24961 ttatattctc attgtcctag ttaccttgcc ctttctttca tttattttta atcattatat
    25021 caacattaat tacaaatgtc tatagaaaat taactaattt tagttattca atatacaact
    25081 tattctttaa atttattctt cttcaacttt aaagtcctga ttatttaaaa ttctgtttaa
    25141 tacaattcca acaattgcag ctaaactaag accagttatc tttactgtac ttgttatagg
    25201 gattccaaca gaaatacctt tattagataa atatgttgtt ccaagaccta ttaataatat
    25261 aactgctatg attaatatat ttattttact ttctacacaa gaactgtccc ttatagtttt
    25321 taatcctaca taagttatca tcgaaaatag cattatacta attccaccca taactgaacc
    25381 tggtatactt tgaagaaatc caccaaactt gcctacacat gcaagcaata tagcaaatat
    25441 tgctgtacgt ctaagtattg aagggtcata gtttttagtt atagcaagta ctgctgtatt
    25501 ttctccataa gttgtatttg ctggtcctcc taaacaccct gcaactatag tcgcaaatcc
    25561 atccccaagt aatgttctat ttaatccagg attttctata aagtttttac ctactacagc
    25621 accattagta gtcatatctc ctatatgttc cataaataca gctaatacaa ctggagatat
    25681 aatcactatt gctcctaaac tgaacttagg aactgtaaag ttaggtattg caaataaact
    25741 tgcttctgta atagtagtta tatctactaa tcttaatatc aaacagatta tatacccaga
    25801 aaaaactgct attaatattc ctaattgttt tataaatcct ctaccaaact tattggttaa
    25861 aattgctatt gctaaagtta taaatgctat cacaaaattg gctgaagcca tactaaaagc
    25921 tgttggcaat aaatttaatc ctataactac tatcatagct cctgtaactt gtgcaggaaa
    25981 atataattta attttattta caccaactac ttttactata atcgacatta taatataaat
    26041 taatcctgct actattatac caccttgagc atatgctaaa tctccaccat acgcctcttt
    26101 agctgctagt ataactggta taaacgcaaa acttgaacct aaaaaggcag gtacttttcc
    26161 ttctgtacaa aaatgaaata tcaatgtacc aacaccagca cagaaaattg caactgacgg
    26221 attaaaacct gtcaaaatgg gaactaatac tgtcgctcca aacatggcta atagatgttg
    26281 taaagacatt atcgtttttt tcataaaaac ctccaaaatt attatatata aataaatcct
    26341 ctgtttaatt aatacctttt aattaattat cattccctag attctatttt ttaacctcta
    26401 tatacttatt atataattta tcattatttt acattttacg acatcaaaaa ctcaaataaa
    26461 ggagaataaa aactacatta agactcacat ccataaaatt ataatattta ttttgtgcaa
    26521 tctatgtaag ctttatcctc ctccctgact attcaatgct aagcttttat ataatactta
    26581 aaaataatta ttctttgatt gtaactgaat cttctccatc aatttctaat aaactgacag
    26641 atataatttc atgtctagaa gtaggtacat tttttcctac ataatctgct cttataggca
    26701 actctctatg ccctctgtcc actagcactg ctaattgtat tgatttaggt cttcctatat
    26761 ctataatagc atctagtgaa gctctcacag ttcttccagt gtataaaaca tcatcaacta
    26821 aaactactgt cttatcattt acattaaaat ctaaataagt tcctttaact acaggttcaa
    26881 catgaatttt ttccaaatca tctctataca aagttatatc aatatctcct gtatctactt
    26941 ttgttccttc tatttgttct attttcttag aaattctatt tgcaattggc acacctctag
    27001 tctttattcc aactaaaact agattttcta cacctttatt tctttcaatt atttcatgac
    27061 ttattctagt aattgctctt gctattgcct tttcatccat taattgagct ttttctacca
    27121 tatcataatt attgtcaaag atataatata tctatttgac aaatctactc ctttctttta
    27181 attttttata aatttatttt tatttaaaat ttcaatttaa acaacaaaaa aacttctcat
    27241 cacaagacaa gaagctctta tataaaaaat atacagtgta atttagcaat tgtcttacga
    27301 tatctctgta tcgtttaaag ataatttttt aatctatcaa ctcaaattat atatttatat
    27361 ttcaaatttt tcaagctttt ttaaacaaaa tactttaata taagatattt tatttaaatt
    27421 tcactaaatt tatttactta tataaaaaca aaaaatgatt tataagtatt atacaaatgg
    27481 ttattttatc tttttaataa cttccttaaa atactcaggt aattctgaat taaattcgat
    27541 atattcctta gtagtaggat gtataaatcc caacttctta gcgtgcaaag tttgtccttt
    27601 taatttaaat ttagtttctt ttggaccata tacataatca cctaaaagtg ggtgatttat
    27661 agacaaagca tgaactctta tttgatgagt tctaccagtt tcaagcctag ctctcatatg
    27721 tgtaaactta tcaaatcttt ctacaacttc aaagtgagtg attgcatttt ttccatcttt
    27781 tactacagcc atttttaatc tatccttagg atttctccct ataggtttat caacagttat
    27841 tttatcttct ttaaccacac catagcatat aaattcatac tccctagtta tagtatgttc
    27901 ctttaactgt tctgctagaa aattatgtgc ataattgttc ttagctatca taagaagacc
    27961 agaagtatct ttgtctattc tatgaactat accaggtcta ataactccat ttattgatga
    28021 caacttatct ttacaatgat ataaaatccc atttactaac gtattttcat agtttccagg
    28081 agcaggatgg acaaccatat cctgaggttt atttattatt aagacatcat catcttcata
    28141 tacaatatct attggaatat cttgaggtaa aacttctaat actttaggtt ctggtatctc
    28201 tataacaata ttatcttcct ctttaaccag atatctagct ttttctactt tattattaac
    28261 ctttactttt ccatctttta taattttttg tatataactt cttgacatat cacctaattg
    28321 ttctgctaga taaatatcaa gtctaacttc ttcttcctct tcaagtacta aaaactcttt
    28381 tacttcatcc attatatcac ctacttttac tttcaaaaaa taaaacatat atacataaaa
    28441 acacagttcc tacaactaca aatacatcag ctacattgaa tacatattcc catataactc
    28501 taaagtcgaa gtaatctacc acaaaaccta atcgtactct atcaactaga tttcccaatg
    28561 caccagatat aattaatata attcccaacc ttccaaatat atgtactttc cttgtattaa
    28621 gatagtataa tccaaatacc gttgcaagta atgcaacaat tataaatatc cattgattat
    28681 tttgtaataa tccaaatgct gcacctctat tttcgacata agttaaatga aatacattat
    28741 ttattattgg tattgttgat acatccacca aattattcaa tacccatatt ttagacagtt
    28801 ggtctaaacc tatgagtaga attattatta atatatatag caatgatttt tccccctata
    28861 aattatttaa aaaccaattt tatttgaagc acactattat tattatacaa aaaaaatgct
    28921 ctaaagagca actttattaa aattgtattt tcttaataaa gctagaacaa aatttaaaat
    28981 agtactactt tttttatatt gtagatttct acatatttaa aatcatatca ttatgtataa
    29041 aaaatttaaa aataccatac taatcaatat tttttgtgta ttttatagat taaagattaa
    29101 tgatgtctgt aatttaaact tacaatcacc actaatcttc aaacaaatat ttttactttt
    29161 gcacttgctt atttttatct aaatgttgta taagttcaga tactgttacg aatttatatc
    29221 ctctctcttt taatttagga attactactt ctaaagcttg tatagtttgt gatttatcat
    29281 ttcttttagt gttataatca tgtaaaagta ttatattacc attttggacc tttgtaagga
    29341 tagtatttat aattgcatct actccagggt tagaccaatc tctagggtct aagtttgacc
    29401 aaagaattat attcattcct ttagaaacta taatatcaca gacactttta ctcatggctc
    29461 tatatggagg tctaaatatc tttggttcta ctcctatcac actttttata atattttgcg
    29521 tatctgttat ttctttttca acactactat aactattttt tgcaacattt atatgtgtaa
    29581 atgtatgatt ccctatttca tgcccctcat catattgtct ttttaataat tctttgttat
    29641 attctacttt ttctccaact acaaaaaaag ttgcttttac atcatttttc tttaatatat
    29701 caagtacttg tggtgtaaaa tcctcatctg gaccatcatc aaaagtcaat gctaaaattt
    29761 tttcatcctc atttcctttt tttattatta catcttcata atcgtctttt atattgtcat
    29821 ttaaactata tgcttctttt gaactatctt gattatgtgt attatgatta tatgtatata
    29881 cacctactat agataataaa catatacata taccacatat tattttcttc atgtcattac
    29941 ctcttttcta attcattcta gcaatatatt ttataatgtc agttttttaa tctctcaata
    30001 ttccattttt atttaaatca gttaaatttg ttaggtcttc tgaataaaag ttagaatctt
    30061 ctacatcagg gttttgcatt gcatcaccta ataaattatt ttccttcttt gcacaatcat
    30121 tacataaact tgtatctggc aatatatcca atctttctaa atctatttga ttatgacata
    30181 aatcacaaat cccatatgtt ccattctcta ttttagataa tgctaagtct atttgataca
    30241 atcttccctc ttcatgattt attagactgt tttgcatatt ttgcatatat aaatctgttc
    30301 ccatgtctcc tatatgatta tcataactag ataattctcc tgatgaatac ttttcacttg
    30361 tatgtttagt tgtatctcca aataaagtat tatctttcat atcctctact aaattagtta
    30421 aattttctct ttctttcaat aatttatctt tatatttttt agtatccatt tttaacacct
    30481 ctaattttaa tatttacatc ataaaaatag tatgtggaaa agtaaattaa acatacaata
    30541 aaaataagat ttgattcgaa aaatggaatg tctcaaaatg aaatttttag ttcatttaac
    30601 cctctttttt atatgaaatc aaatatattt ttatcctttc agcaataaaa aagagactta
    30661 tctctatttt gagatagtct cttctttgaa cataatttaa atacaatttt ttaattttta
    30721 tagttattat tttactaact tgccaattta tgattatttt gttctttaat atgttttgct
    30781 tttttaaaga ataaaagacc aagaattatt gctacaataa cacctattcc attagatata
    30841 ttaactggta gtctaaatcc ttcttttgct tgcattatat aactaaatgt tactacagtc
    30901 ataaaaagtg ctggtaatgt agttatataa tggtttttat ttgctttgac taaatatgca
    30961 gaaccagtcc acaacattat cattgcaagt gtttgatttg cccaagagaa atatctccaa
    31021 attatattaa aatctataaa tgtaagagca acaccaactg cgaataatgg taaagctatt
    31081 aaaaatctat ttttgactgc atcttgatta taattcattg catctgctat tgtcagccta
    31141 gcacttctaa atgctgtatc tccagaagtt ataggacatg ccacaactcc aagtatagct
    31201 aaagctcctc caataggccc cattaatcca acagatactg tatttactac tgttgctgct
    31261 ccaccatcat taaatatcac attaagttga ggtatgccat ggaaatatga catggctgct
    31321 gctgcccaaa ctaaagctat tataccttct gcaaccattg acccataaaa tactggtctt
    31381 gcctcactct ctttctcaac acatctcgcc ataagtggtg attgagttgc atgaaaacct
    31441 gatattgctc cacatgctat tgttataaat aagtatggga ataaaggtgt tccatttgga
    31501 ttcatatttt gtaaatttat atttggtatg ttatacccct ttattattaa tcctccagct
    31561 acacctactg ccataattaa taatgctgct ccaaataaag gatatatttt accaatcaat
    31621 ttatctattg gtaaaacagt agccataata taataaagta ttatcactcc aacccatatt
    31681 tgtgcgttta cacctgtcaa tgtctttaat aatcctgctg gacctgttac aaatacaact
    31741 ccaaccaata ctaaaagaat aacactaaat attctcattg ctatttttgc accatttcct
    31801 agataaaggc ctaccaactc tgatgcagat gtacctttgt ttttcattga tagatatcct
    31861 gaagcaaaat cgtgtactcc accagcaaag attgttccaa acacaatcca taaaaatgct
    31921 gatggtccaa ataatgctcc ttgtatagct ccaaatatcg gacctaaccc tgctatattt
    31981 agaaactgaa ttaaaaagat tctcttccat ttcattggca cataatctac tccatcccta
    32041 caagctatag ctggagtttg atttttgtca ttggttccaa aaaccttttc tacaaaagta
    32101 ccatagacaa aataacctac tataagtact actattgaac ctaaaaagct taccataaat
    32161 tcatcccctt agtttttata taattgcttt ataaattttt atgagtttaa gaaaactatt
    32221 tccagttcaa atagtaatac ttttttatgc taatataaat attaattaca ttaagtgcat
    32281 atttaagtac atgaaatgac tttatatatg cattaacagc ctaaattctt ttactttgct
    32341 tctacttaca gttacttcat aatcactatt ttttaatttt aatatgtatg tattattaaa
    32401 ccatggtata atttctttta ctttggttaa gtttacgata taagacctat gtgttctaaa
    32461 aaatgtttta tcatttataa gattttcgac ttcttatatg ccttctttta atataaactt
    32521 ttctttctca gtatatataa atgtctgcct ttcattagct tcacagtaat atatatcatc
    32581 aatatctatt acaactaatt tatcaccttt ccaaaggcta attttatgtg ttatttcttc
    32641 tatctcctga tttactgctt ccttcttata tttgtataaa ttactattta cattaaatag
    32701 ttcaatatca ctcatctcac ttttttctaa tttattcagc atagaaataa ttctctcttc
    32761 agaatatggt ttcaatatat aatcaaatac atccaaagaa aaagcatcta ctgcataact
    32821 ttcatatgct gttataaaaa caattttagg tcttgattta aactgattta atgtttttgc
    32881 aagtagcatt ccatcaagat gaggtatatt tatatctaaa aaaattacat ctattttatt
    32941 ttcctgaata aagtctaaca cctctatacc attggtaaat tcacttacta cctcgattcc
    33001 acttttattt tcaataaaat atctcaattc ctttcttgct ggaaattcat cttccactat
    33061 tatagctctc atacttctac tcctttacat aaaatactat caaagtccca ttatctattc
    33121 ttcttatatt aagccctctt ccatacatca gtttaagcct taaatgtaca ttataaagcc
    33181 caatcttatt ttctggcata ttatcttgat atacattatt tataatttcc tcacttatac
    33241 ctataccatt atcctctatt gatattctca cagtattttc taatgaatac ggtaactttt
    33301 ttatggatat tttcactaca ccagctctac cactttctaa aataccatgt attattgcat
    33361 tttccactaa tggttgtata atcaaacttg gaatctttat atttacatct tctatatcat
    33421 aagatacagt tagtaattct ccaaacctag ctttttctat ctctacaaaa gatttaactt
    33481 gttcaatctc tttatttata tcaattaagt tatcactata ttcaagatta tatcttagat
    33541 aagttgataa atttattatt aactctctag ccttatctgg actaaatctt ataaatgaag
    33601 ctattgtgtt tagggaatta aacaaaaaat gtggattaat ttgtctttga agtgctttta
    33661 tttctgcttt atttctcgct tctatatctt ttttatcttt ctcaatcccc tctactatag
    33721 atataacaaa tcctattcca atctgcccaa ctattaaagg taaatatatt ccaccgatta
    33781 tttgaattgc taaagaatgt ggatatgata ttaagtatat aagtaatata gtaaaacttt
    33841 cagaaatcat gcctaccaat attccataca ttactctatg ttgttttggt atcctcttat
    33901 atagaaatcc tgataataca cctgctagta tacttgataa aagacatgga acagatgtta
    33961 tccccccaat atccataaaa tatctatgaa tccctgaaaa aactcctgct gtaataccta
    34021 ccatcggacc aaataaaatg ccacctgata ctatagatat tattctagtg tttactattg
    34081 accccatata atttatacca ctataagttc caaatatggc taaaaaagta aaaactaatg
    34141 ctatacagac caagtcatta aaactatatt cttccttttg aaatatctgc ttaaatattt
    34201 ttaactttgt tattagaaga aacaatacta caataaggct tgtcttttct attaatgcga
    34261 ttaaaattga tgttttcata atcccccttt aaaaaataaa tttttacaca ctctaaattt
    34321 attatggttg ttataaatta catatttgaa gtaatcctat cacaaaactt tccacattta
    34381 atcttttaat taaataagaa atagttgtac ttctattaac aactaatact agctagcata
    34441 agcttgtaat aacttgtagt tattattaac tttacaattc tagtatttaa ttttatactt
    34501 tagaaatctc ttttcttaga aataatactt tcgaatatca tataatacaa tattatgtag
    34561 attcttactc atacaacata tttctttaaa aattttatac tattctttgt tcaaatatct
    34621 catttgattt aattgtgtta aacacacatt atcatctctc tgttatatat ttattatata
    34681 gccgtatatc gataaagtaa ataaatccca tatttaaaat aatatgtttg acaataaatt
    34741 attataatgt
//
LOCUS       DAEHWM010000035        33719 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.036, whole genome shotgun sequence.
ACCESSION   DAEHWM010000035 DAEHWM010000000
VERSION     DAEHWM010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 33719)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33719)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33719
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.036"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            139..585
                     /locus_tag="KNP36_001786"
     CDS             139..585
                     /locus_tag="KNP36_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873661.1"
                     /translation="MAISDLAFGTECLKTSFQMLFSVISLVNINLLQAQILIAIGGLI
                     SILAMVSLTLFLSAKCKDSLTSMLIAFSICLIPMGIGVSWIGYLLPPGGIGFKISLLY
                     QMTSFNFLHLGGMSFWTPHIILFFSVIEIPIFIFLAIHTYCKHQVS"
     gene            966..1883
                     /gene="pstC"
                     /locus_tag="KNP36_001787"
     CDS             966..1883
                     /gene="pstC"
                     /locus_tag="KNP36_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HBF0873662.1"
                     /translation="MIVKSRLVGLEKNDNNGNKTKYVIEKVAKNIFLLSALVAVASLL
                     LIIGFVFYKGLRPFIFEGYSFIDFLTGADWVPSANKFGISSMIVASIFATLGALVIGV
                     PVGILTSVFIAEVAPKRLAKIMSPAVELLAGIPSVLYGVFGLAVIVPTIQSIFNLPKG
                     QSLLAIVIVLAVMMLPTIISVSETAIRAVPKAYKEGSLALGASKIETIFKVVLPAAKS
                     GVLAAVVLGVGRALGETMAVILVAGNSPVMPTAITDSVRPLTTNIALEMGYAFGTHQE
                     MLFATGVVLFTFILILNLVLNKLSNKAVN"
     gene            1885..2709
                     /gene="pstA"
                     /locus_tag="KNP36_001788"
     CDS             1885..2709
                     /gene="pstA"
                     /locus_tag="KNP36_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003460575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HBF0873663.1"
                     /translation="MRKFKENLLKSLVYLSALFTIVSLVVIVGFIFIKGIGNMNFNFL
                     FSNYSASGDGGILPMIITTLYTVVVSIVVATPIGILAAIYLQEYAKKGKAVTAIRFAT
                     ESLSGIPSIVYGLFGGIFFVVTLKMGYSIVAGSLTVAIIILPVIIRTTEEALKTVPQA
                     YRESSLALGATKFQTLYKVVLPSAIPGILSGVILSVGRIIGESAAILLTAGTVAKMPG
                     GIFDSARTLTVHSYLLTKESGDIATAASIGIVLIVIVLALNMLARFVAKKLNKANY"
     gene            2728..3492
                     /gene="pstB"
                     /locus_tag="KNP36_001789"
     CDS             2728..3492
                     /gene="pstB"
                     /locus_tag="KNP36_001789"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HBF0873664.1"
                     /translation="MELIDKIKMSVKDLDLFYGDKQALKKINMDIKENKVTALIGPSG
                     CGKSTFIRTLNRMNDLIEDVTIKGNISVDGEDIYTSDDVINLRTKVGMVFQKPNPFPM
                     SIYDNVAYGPRTHGLRDKKQLDKIVEESLKGAAIWDEVKDRLKSSALGLSGGQQQRIC
                     IARAIAMRPEVILMDEPTSALDPISTLKVEELIEDLKKDYTIVIVTHNMQQAARISDE
                     TAFFLNGEVIEFSDTKTMFTTPVDKRTEDYITGRFG"
     gene            3520..4173
                     /gene="phoU"
                     /locus_tag="KNP36_001790"
     CDS             3520..4173
                     /gene="phoU"
                     /locus_tag="KNP36_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HBF0873665.1"
                     /translation="MVNNSLDISIDTLKEQTVLMMEKCEEAIEKSVTCMIEKDLEGAR
                     KVVEDDEEINKLREEIRDKSIELIVLKQPMARDLRFIYSLGNISIELERIGDYAANIA
                     REMLKIGGEAYIKELIDIPKMAKECKSMMSQTREALILFDASIAYDVGTKDDIVDGLY
                     EQVQIDCLKIMHENSNTIDQGVKLLLIGRYLERIGDHITNVCEKIIFAIEGKMVEIG"
     gene            4331..5200
                     /locus_tag="KNP36_001791"
     CDS             4331..5200
                     /locus_tag="KNP36_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBF0873666.1"
                     /translation="MKLQKMGMRTIKTGISVTLCMILGDYLVENMFYSLVACIISVQD
                     TVKGSLKTGINRVEGTILGGIIGFIFAIIKAGDPFLCGLGVMCSIYLCNLFKIKSVVV
                     ACVTFLAIHLGVGNSDPVYYSLHRVLDTSVGVLFGVLVNYYVARPNYLNSVIDEFKKI
                     EELSMLLIEDKILRKENLNVEKFEEEVEKLEEIYSKLIDELDYSLSETNIEKIENALR
                     ICREIHFHMQSIELLENKLYLKEHTYKYLKKTYNVDKLDWNIDEEKSPVFNYHLMKIM
                     IEIELLRKLNKSY"
     gene            5287..6723
                     /locus_tag="KNP36_001792"
     CDS             5287..6723
                     /locus_tag="KNP36_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase"
                     /protein_id="HBF0873667.1"
                     /translation="MNTRNDNSKILEIYKMKLFGELVKAVWNDDIEDIENLPNKILNE
                     NLKDNLNNYFSGKFDKDTMVNLIRVTMGLDVTEDTDKNLKESLHEAVNLDEVKRPIIS
                     VISDACKYCDENNKEDESCKIRSKHINCNEEDVCSACGDCVSRCKLGAISDKIEFIPM
                     IKLLKDIKSPVYAIVAPAFVGQFGKDVSPGKLRTALKKIGFEDMIEVALAADMLTAKE
                     AYDYYEHMKKDEEGCFITSCCCPIWVSLIQNSFPQILENVSPSVSPMIACGRAVKILN
                     PDAKVVFIGPCMAKKKEAMLEDIKDAVDFVLTFKELQEIFDALELNPAIMDESNRVEA
                     SLSGRVYARTGGVSKAVKLSVRRIDKNIKFEEKAFEGTKECMDGLKKVLNKEIEATFI
                     EGMGCVGGCVGGPKRILSVEEGTKNVDEYSESTNMETPFDNLNVLQFLTSLGIKRVES
                     LGEKEEEKVKKIFSRDIKSNKKENKYKK"
     gene            6771..7598
                     /locus_tag="KNP36_001793"
     CDS             6771..7598
                     /locus_tag="KNP36_001793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0873668.1"
                     /translation="MKIKDNKAVFHVFIRIFLIAVLILTGTLLEEKINNVPVENISSK
                     GENTLELLSQSNTLGEIIYKASQEETKGPGATSEKVAYITIDDGPSKYTNALLDILKE
                     NDVKATFFMLNQNMKNHKEEVRRVLEEENSIGFHSVSHDIHKLYKSPEVTVGEFNTCN
                     NTLQEITGQSSKLIRLPYGSKPYMPEGSYNKLMANDYLIWDWNLDTQDWKSSTSQIVS
                     NILYYGRKRDELVVLIHEKEQSLNALNNIIRILKERGYTILPITENITPKNFWQENL"
     misc_binding    7894..8156
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            8232..10898
                     /locus_tag="KNP36_001794"
     CDS             8232..10898
                     /locus_tag="KNP36_001794"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HBF0873669.1"
                     /translation="MENTNLSKTYNPKDFEARLYKKWMDEGYFKSKPNPDKKPFTIMM
                     PPPNITGQLHMGHALDHTLQDILIRWKRMDGYEAFWLPGTDHASIATEVKVVERIKKQ
                     EGKTKYEIGREEFLKRAWEWKDEFGGKISNQLKQLGDSCDWDKERFTMDEGCNEAVIE
                     FFVSLYEKGHIYRGNRIINWCPDCKTTLSDAEVEHEEHDGNFYHIKYPLKDSEDFLEI
                     ATTRPETMIGDTGIAVNPEDDRYKHLIGKTAILPLVGRELPIVADSYVDLEFGTGAVK
                     MTPAHDPNDFEVGLRHNLEQLNTMNEDGTMNEVCGKYEGMDRFECRKAIVADLKEQGY
                     LIKIKEHNHNVGTCYRCHTVVEPRLSEQWFVKMEELAKPAIDILKKGELEFVPDKFDK
                     TYLQWLENIRDWCISRQLWWGHQIPAYYCQECGEIVVARKMPDKCPKCGSTHFKQDED
                     ALDTWFSSALWPFSTLGWPNKTEALDYYYPTSVLVTGYDIIFFWVVRMAFAGMFCMNE
                     KPFDHVLVHGLVRDSQGRKMSKSLGNGIDPLEIIEQYGADALRFTLTTGNSPGNDMRF
                     YMERVEFARNFANKLWNASRFVFMNIDEDIIKNMTRESVKEDLTLADKWIISRANNIV
                     KEATNNMDKFDLGIALQKIYDFTWSEYCDWYIEMVKPRLYGEDANAKSAALYTLTYVL
                     EKILKLLHPYMPFITEEIYTHLPTVEGCIIVSEWPKYNEEDNMAEEEDMMNLLMEGIR
                     SIRNVRAEMNVPPSKKAKLIIIPSEEKIEAIELGKDYFITLASASNVEIAKDKSNVPE
                     DAVGVVIDGVEIFIPLNELVDFEKEIERLSKEKKKLEGEIKRVNGKLANQGFLAKAPE
                     SLIEEEKAKKEKFEEMIKSVEERLTNLESKIK"
     gene            11323..12033
                     /gene="rgaR"
                     /locus_tag="KNP36_001795"
     CDS             11323..12033
                     /gene="rgaR"
                     /locus_tag="KNP36_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RgaR"
                     /protein_id="HBF0873670.1"
                     /translation="MFRVVICDDEKIQRSILKEFTEKLLSERCLNYQILEFSCGEDLI
                     SKYPEKIDIIFLDIQMKDINGIEVAKKIRKFDEKVEIIFTTAFSEYAPQGYEVRAYRY
                     LVKPIEYSNFAMGVNLCIDNLQRKKERYIVLNSKKGFNRILIDSILYVETVKRDLVVH
                     TIGRDYKANMSMKQAEKLLCENGFFRCHTSFIVNLRRIEDLRDNMITINEQFIPISKY
                     RLKDLKVALTSLLCDIMY"
     gene            13079..14110
                     /locus_tag="KNP36_001796"
     CDS             13079..14110
                     /locus_tag="KNP36_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBF0873671.1"
                     /translation="MENICDMNNKVKVAVLDTGIDKEHDYLKDNLVGGIAFECMHDYI
                     FISDKFDDEDGHGTACASIIKKEYEDVELFVIKILRKDGITNIKVLEEALRYLLDTNI
                     RLINLSLSVIGVESVKGLFEVCYELFRKGKIIVCSLANDFDLSYPAMFNNVIGVRGFT
                     LDGDDSFWYNKKYDVQCVMDSNSYISCDINNSYRLPPKCNSYLSAKLTGKIAKILSEK
                     PGITISDLNDKLESLATRNHWDSCDFDECSRIVNFKLDLYDKENALFMKVADVVRDCL
                     DIEENNEKLFKGSLFNKEIGLVYDNCFNLLKKLEHRFDIKFNYMDISKYDLVSIYTLT
                     ELVERYKNL"
     gene            14243..15541
                     /locus_tag="KNP36_001797"
     CDS             14243..15541
                     /locus_tag="KNP36_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HBF0873672.1"
                     /translation="MKYEEALEYISQTNKFGIRLGLENIGKLLELLGNPQETLNIIHV
                     AGTNGKGSVCSFVSNILRECGYKVGLYTSPYLETFTERIRVNGQNIPQDDVARIIELI
                     KEKIEIMVKEGYAYPTEFEVVTAMAFYYYSEQKVDFVALEVGLGGRYDATNIITKSLV
                     SVIVSISLDHTGILGDTIEKIAYEKAGIIKENGVVLVYDQTDEAKDVIKSVCKEKKAK
                     YIEVDFDDINIKKSDINSQIYDCTVMKETYRDLEIKLIGEHQINNSILAISVIKYLKD
                     INKLANINEESIRKGLINTKWPGRIEKIKENPIFIIDGAHNEDGAKSLAKALDKNFKG
                     RKLTLLIGMLEDKDIDSVLEILLSHFNKVITTTPNNPRAINSDILREKVLKYVDDVTS
                     KHEIEDAVNYTLETSSEDDIIISAGSLYMIGTVRTLVKKL"
     gene            complement(15655..15900)
                     /locus_tag="KNP36_001798"
     CDS             complement(15655..15900)
                     /locus_tag="KNP36_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03905 family TSCPD domain-containing
                     protein"
                     /protein_id="HBF0873673.1"
                     /translation="MKVTFNPSGVCCREMIFEVDENNVIVDAEFIGGCNGNLSGLRSL
                     IIGQNALEVADKLNGIDCGGKGTSCPDQLSKAIRQSI"
     gene            16048..16914
                     /locus_tag="KNP36_001799"
     CDS             16048..16914
                     /locus_tag="KNP36_001799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YncE family protein"
                     /protein_id="HBF0873674.1"
                     /translation="MKIYISNYLSKSISIVDYSTLELEKEIVLEDNIYPHHFCIEKEK
                     NLIYIPSSSNGILYVLDLSNDKIIDTVSIGGSLSQVVLSDNELFVANEDSNSIYVLDK
                     NTLNPIGIIGVDNMPHGFDFDRESKKLYVPCINSIVCIDTINKNIQKKINMDFRAWHI
                     ELDKQKKEMYISTLDGKLIIIDEVSMDIKKVLYEFLLPVEIRFNYSGKKVYVADLGYN
                     NVRILDYTTSRYIGNIEINGIPQGLEISKDEKLLFVSDTQENSVKVYETANNKLIKEI
                     KVGKEPTTIICL"
     gene            complement(16918..17454)
                     /locus_tag="KNP36_001800"
     CDS             complement(16918..17454)
                     /locus_tag="KNP36_001800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4364 family protein"
                     /protein_id="HBF0873675.1"
                     /translation="MFENSSEELAYHKLLILYILEKIKMDLTNSQITQVVLETEMMNY
                     FSLQQLLSQLMESKFLTTYKDSDREYYALTQRGVESLEYFFNRIPTSVTEKIDKYIDS
                     NKENLLADTQVKSSFVKQSDNEFIVNLRVIENQSNLIDLNLNVSSEKQAKLICNNWKN
                     NASYMYAEVIDLLIRDIH"
     gene            complement(17645..17848)
                     /locus_tag="KNP36_001801"
     CDS             complement(17645..17848)
                     /locus_tag="KNP36_001801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta-type small acid-soluble spore
                     protein"
                     /protein_id="HBF0873676.1"
                     /translation="MSNSNRTVVPEAKAALNQMKLEIANEIGLSNYENIDKGNLTARE
                     NGYVGGYMTKKLVEMAERQMAGK"
     gene            18139..18903
                     /locus_tag="KNP36_001802"
     CDS             18139..18903
                     /locus_tag="KNP36_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0873677.1"
                     /translation="MKREVKRTKALIYSVLFFSLLLVLIFVFVYGIKYICSKSDNSKM
                     PIYKVDTNEKKIALSFDVAWGTDNMDDILKILDKHNVKATFFLVGSWVDDNEEIVKAI
                     DEKGHEIGNHSNTHANLKEISKEDITKEIETTSEKIYNITGKRTNLFRPPFGDVNNKA
                     MDICSDLGYKVIKWDVDSIDWKELGPNHVIEKVIKESQPGSIVLFHANINDVDNYLDT
                     IISRLKKDGYSLVKISDLLYKDNYVVDSNGVQKTKN"
     gene            19292..20605
                     /gene="prdC"
                     /locus_tag="KNP36_001803"
     CDS             19292..20605
                     /gene="prdC"
                     /locus_tag="KNP36_001803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase-associated electron transfer
                     protein PrdC"
                     /protein_id="HBF0873678.1"
                     /translation="MNKLYSILLKQHVGGPDKPVVSVGDVVKKGTLIAEPTGLGANIY
                     ASVSGKISEINDQAIVIEADEVQEDTFEPLKGEGILDLIKEAGVVGMGGAGFPTHVKL
                     NIDLNGGTILANAAECEPLLAHNIKEIEERPEIVYQGIKYAMEVTNAGKGMLAIKSKH
                     PKAIEAFKKVIKPGDNIEVAELVDMYPMGEERAIVRDVLGKLLEPTQLPSEANAVVIN
                     VETLTRIVEAVEQKRPVISKNITVVGQLNSGKESIVFEDVPIGTTVGELIERAGGIKG
                     EYGEIILGGPFTGKATTLDAPITKTSGGIIVTMPFVNEKRKMGLLVCACGPNEERMRD
                     IATKMGVTDIVSVQKCKQAQEIKGALKCENPGHCPGQAQKCIEFKKAGAEVILIGNCT
                     DCSNTVMGSAPKLKLGVYHITDHVMRTVNHPLIRRIKGDVRLKIK"
     regulatory      21010..21095
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            21677..23851
                     /locus_tag="KNP36_001804"
     CDS             21677..23851
                     /locus_tag="KNP36_001804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cys-Gln thioester bond-forming surface protein"
                     /protein_id="HBF0873679.1"
                     /translation="MKTKIKKSSIISLVIAFSMVFTAFTPIVSYADEVTSNDTILNGE
                     EQSNGQTPDVEKPSDGQVPDGEKPSDSQVPDGEKPSDGQVPDGEKPSDGQIPDGEKPS
                     DGQIPDGEKPSDGQIPDGEKPSDGQIPDGEKPSDGQMPDGEKTSDSQTPDVEKPSDGQ
                     MPDGEKPLDEQTPEEEKPLEEEIVIEEMSLKQDIDKILDMTLSQINKIVYNFWEDEED
                     VKADEQSEINQVFTSEDSFISLWYDKKAKVKNSCLLKEIDGSDRPYHDLRFDDITKTL
                     TFDYVIKGLVGASSKDDKYVIEGEDGEQTAFCYNNHLRPPSSNGKSPYLPAEDFNGQE
                     NQNEEAVKSILYAGSEFDGFGYKQQFNLGGEENELMTYSATQSAIWIILGQMDEQERL
                     KQYQGSINLCDKLIERAKTEEERAEYQKKKEVAINIKAYLEALLKAGREELKPNDTGK
                     PSLSNGLTKINFEKNEDGTYETEAVALVGYSGVVKLRLPDGVTAYDGDGNIIGTGEVE
                     ISTQQKFKLKSVVKPDAKANISAVSYDYIFPKAIQYYKAVLDLGQKDHSSSLPSSKQN
                     LLSYTIEKKNGQEVNFNIGLPTDDVVNPPVPPTDDTNGHKPKPSPPIDDTVINPPVPP
                     MDDTIINPPVPPTEDAVLNPPVPPTEDAVLNPPVPPTEDTVLNPPVPSVSDTVEKTPE
                     LSRDDTIIKSPKTGDETQLMSYVFISVIAICGLAYQCKIKRN"
     gene            24258..26018
                     /gene="prdR"
                     /locus_tag="KNP36_001805"
     CDS             24258..26018
                     /gene="prdR"
                     /locus_tag="KNP36_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54 dependent transcriptional regulator
                     PrdR"
                     /protein_id="HBF0873680.1"
                     /translation="MFSIPEVKKVEEVMDTKFTTIDEDTRIEDAIKEMIKSNTKTLMV
                     IDSSDQLKGIISMTDIHNLYEMHKKYEGQPVKLIMKKDVIYVNEGLTLDECRDIMILK
                     NIGILPVLRDNKIIGVLKQEHIRDYLYMHLEDYGLTLKYIIGQIKEGICAINNEGVVI
                     LWNKFMEERYDIKSEDIVGRPMNEFLENTISEKVLNSKVGMSDLYFTDKKENMYALVH
                     ANPIFYKEEFIGVVCTEVDVTEAKILALELEKVNDTLKYLKNEVKNLSKGSFDKILGK
                     SYKLEKSKAIAKQVARTNSSIFIWGESGTGKEVFARAIHDYSERKGQFIPVNCSAIPN
                     ELFESEFFGYESGAFTGASKKGRIGIFELAKDGTVFLDEIADLPLSMQAKLLRVLQEK
                     EIRRVGGDTTIKINPRIISATNKDLSKMVKAEKFREDLYYRLNVVEIKIPPLRERKED
                     IGLLVHSFLEEICKQNNKPVLTISKDVIDIFQNYRWKGNIRELKNTIENIVVLSQNSK
                     IDVDDVPSYMMDSTNNSTEEEEYPLDLTKATQKIEIKNITKALKMSNGNKAKAAKILN
                     IPRTTLYYKIDQYKIDVSKI"
     gene            26447..28327
                     /gene="prdA"
                     /locus_tag="KNP36_001806"
     CDS             26447..28327
                     /gene="prdA"
                     /locus_tag="KNP36_001806"
                     /EC_number="1.21.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-proline reductase (dithiol) proprotein PrdA"
                     /protein_id="HBF0873681.1"
                     /translation="MSITLETAQAHANDPAVCCCRFEAGTIIAPENLEDPAIFADLED
                     SGLLTIPENGLTIGQVLGAKLKETLDALSPMTTDNVEGYKAGEAKEEVVEETVEEAAP
                     VSEAAVVPVSTGVAGETVKIHIGEGKNISLEIPLSVAGQAGVAAPVANVAAPVASAAA
                     EVAPKVEEKKLLRSLTKKHFKIDKVEFADETKIEGTTLYIRNAEEICKEANETQELVV
                     DMKLEIITPDKYETYSEAVLDIQPIATKEEGELGSGITRVIDGAVMVLTGTDEDGVQI
                     GEFGSSEGELNTTIMWGRPGAADKGEIFIKGQVTIKAGTNMERPGPLAAHRAFDYVTQ
                     EIREALKKVDNSLVVDEEVIEQYRREGKKKVVVIKEIMGQGAMHDNLILPVEPVGTLG
                     AQPNVDLGNMPVVLSPLEVLDGGIHALTCIGPASKEMSRHYWREPLVIRAMEDEEIDL
                     VGVVFVGSPQVNAEKFYVSKRLGMLVEAMEVDGAVVTTEGFGNNHIDFASHIEQIGMR
                     GIPVVGVSFSAVQGALVVGNKYMTHMVDNNKSKQGIENEILSNNTLAPEDAVRIMAML
                     KNAIEGVEVKAPERKWNPNVKLNNIEAIEKVTGEKIVLEENEQSLPMSKKRREIYEKD
                     EN"
     gene            28408..28692
                     /locus_tag="KNP36_001807"
     CDS             28408..28692
                     /locus_tag="KNP36_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873682.1"
                     /translation="MDRLKYISSETFYEGIIVDIKGGGVTIDLKGRLGQFKIPNRMLI
                     TDYELKIGQEVGFMLSYPEVLSPEPNQEYVENIRREKEKQAEMQSKQEEK"
     gene            28730..29455
                     /gene="prdB"
                     /locus_tag="KNP36_001808"
     CDS             28730..29455
                     /gene="prdB"
                     /locus_tag="KNP36_001808"
                     /EC_number="1.21.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:29180..29182,aa:Sec)
                     /transl_table=11
                     /product="D-proline reductase (dithiol) protein PrdB"
                     /protein_id="HBF0873683.1"
                     /translation="MSLTTVQGLQSEIFVPITPPPVWTPVTKELKDMTIALATAAGVH
                     LKSDKRFNLAGDTTFRAIPNTATVDEMMVSHGGYDNGDVNKDINCMFPIDRLHELAAE
                     GFIKGVAPMHYAFMGGGGNQHVFTEETGPAIAAKLKEEGVDGVVMTAGUGTCHRTAVI
                     VQRAIEEAGIPTIIIAALPPVVRQNGTPRAVAPLVPMGANAGEPHNIEMQTHILRDTL
                     EQLVAIPSAGKIVPLPYEYKAHV"
     gene            29535..30293
                     /gene="prdD"
                     /locus_tag="KNP36_001809"
     CDS             29535..30293
                     /gene="prdD"
                     /locus_tag="KNP36_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase cluster protein PrdD"
                     /protein_id="HBF0873684.1"
                     /translation="MEEKIMRRLVIKPFHMNEVNFGSKTSIKKDVLTIDLSSIDEIKE
                     REELITDIKVDIIKPGDYDREINTIMDIIPISTKVLGRLGEGITHTLTGVYVMLTGAD
                     EDGNQMHEFGSSEGILKDQMVFGRYGTPSVEDYIIHVDVTLKGGLPFERTLPLAAFRA
                     CDDFIQEIRASLKMEDGRNATQVREYFDKIRPNAKKVVIVKQIAGQGAMYDNQLFSKE
                     PSGFEGGTSIIDMGNVPMIISPNEYRDGALRAMT"
     gene            30308..30775
                     /locus_tag="KNP36_001810"
     CDS             30308..30775
                     /locus_tag="KNP36_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase"
                     /protein_id="HBF0873685.1"
                     /translation="MGIGPSTKETSLHHFRDPLLDIVESDKDVDLLGVIVVGTPDGNE
                     NKTFVGQRTAAWLEAMRVDGAIVSSDGWGNSHVDYANTFEEIGKRDIPVVGVTFNGTQ
                     AKFVVSNQYMDTIVDMNKSKEGIETEVVGENNTNEIDAKKALAFLKLKMRKHG"
     gene            30793..31275
                     /locus_tag="KNP36_001811"
     CDS             30793..31275
                     /locus_tag="KNP36_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline reductase"
                     /protein_id="HBF0873686.1"
                     /translation="MSFVGISTSMKNTSLHIFRDPLLDLIDNDSDIDLLGVVVVGTSE
                     HNEWKTFLATRLGRWIESLRPDGVIITLDMAGNQHIDFTNAIAEFVKSDIPTVGLTIM
                     GADGLVITNPYLDKATIIDYKKTTGYIETEVVGDNHMDEVDVKKALAFLKLKMRKDAK
                     "
     gene            31295..32302
                     /locus_tag="KNP36_001812"
     CDS             31295..32302
                     /locus_tag="KNP36_001812"
                     /EC_number="5.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline racemase"
                     /protein_id="HBF0873687.1"
                     /translation="MKFSRSIQAIDSHTAGEATRIVVGGIPNIKGNSMPEKKEYLEEN
                     LDYLRTAIMLEPRGHNDMFGSVMTQPCCPDADFGIIFMDGGGYLNMCGHGTIGAMTAA
                     IETGVVPAVEPVTHVVMEAPAGIIRGDVTVVDGKAKEVSFLNVPAFLYKEGVEVDLPG
                     VGTVKFDISFGGSFFAIIHASQLGLKIEPQNAGKLTELAMKLRDIINEKIEIQHPTLA
                     HIKTVDLVEIYDEPTHPEATYKNVVIFGQGQVDRSPCGTGTSAKLATLHAKGELKVGE
                     KFVYESILGTLFKGEIVEETKVADFNAVVPKITGSAYITGFNHFVIDEEDPLKHGFIL
                     K"
     gene            32422..33303
                     /locus_tag="KNP36_001813"
     CDS             32422..33303
                     /locus_tag="KNP36_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TSUP family transporter"
                     /protein_id="HBF0873688.1"
                     /translation="MVAILKALYVVFAAIFAVVFGKDVAKANKEGKLEEQSTPKVAVT
                     GFITDFFDTLGIGSFAPTIAMSKALKLNIPDKKMPGTLNVAHTIPVVTEAFIFTSIIP
                     VDGVTLVSMVVAAAVGSYIGAGIIAKMDERKIQLVMGVTLALTAILMLLGHPWINVLP
                     GGGNELGLTGAKLVIGVIGNFILGALMTAGIGLYAPGMAMVYFLGMSAKVAFPIVMGS
                     CALLMPVASMKFIKEDAYTKKASVIIAICGLIGVFVAAYIVKTLPMDILKALVIVVIA
                     YTSATMIMAANKNKKTA"
BASE COUNT        13417 a         3742 c         6178 g        10382 t
ORIGIN      
        1 ttttctggtg agtatcagac acaatcagat agcatccttc gttgtacgaa acatggacat
       61 atttgtctag cgtttactaa aatattagct ctattttcta tatttataat aatgtttgtt
      121 atatgtattt ctatctattt ggcaatttct gatttagctt ttggtactga atgtttgaaa
      181 acctcatttc aaatgttgtt ttctgtcatt agtctagtaa atataaattt actacaagca
      241 cagattctta tagctattgg tggtctaatt tcaatacttg caatggttag tttaacatta
      301 tttttatctg caaaatgtaa ggattctctt acttctatgc tgattgcttt ttctatttgc
      361 ttaattccta tgggaatagg tgttagttgg attggatacc tattaccgcc agggggaatt
      421 ggttttaaga ttagtttatt atatcaaatg acatcattta atttcttaca cttaggaggt
      481 atgagttttt ggacaccaca cattatactg tttttctcag tgatagaaat acctattttt
      541 atatttttgg ctattcatac ctattgcaaa catcaagtat cgtaacaatt tgatggaaat
      601 aatagtgata taaactagag gatacaataa ttatatatgt agtataaaag ttaaatttag
      661 ttaacaaatc ttaatagcag atataggtaa taaattatac ataaactgta ttattatcta
      721 tatctgctat tttaatatag agaaacaaca gtatattgta aagtaaatgt caaatatagt
      781 tttaaaagta aaattaatgt taaaaagtaa atataatttt acacttgctt aacttaatcc
      841 taatatagat ttaacttaaa aaaagtagaa taaaagtaca ggaaatttga tgaagacgaa
      901 ttataaaaaa ttaaattttg aatacagaac gaaaatcgat aagtatattt taatgggagg
      961 gtattatgat agtaaaatct agattagtag gtttagaaaa aaatgacaat aatggcaata
     1021 agacaaaata cgtaattgaa aaagtagcaa aaaatatttt tctacttagt gctttagtag
     1081 cagttgcaag tttacttttg ataataggat ttgtatttta taaaggatta agaccattta
     1141 tatttgaagg atattcattt atagactttt taactggtgc agattgggtt ccttctgcca
     1201 ataaatttgg aatatcatct atgatagtag catcaatatt tgcaacactt ggagcacttg
     1261 ttataggagt acctgttggt atattaacct ctgtatttat agcagaagta gcacctaaaa
     1321 gattagcaaa aataatgtca ccagcagttg aacttttagc aggtatacct tcagtattat
     1381 atggtgtatt tggtcttgca gtgatagttc caactataca aagtatattt aatcttccaa
     1441 aaggtcaaag tttgttagca atagtaatag tattagcagt aatgatgtta ccaacaataa
     1501 tatctgtatc agaaacagca ataagagcag taccaaaagc atacaaagaa ggttcattag
     1561 cacttggtgc atcaaaaata gaaacaatat tcaaagttgt attacctgct gcaaaatctg
     1621 gagtattagc cgcagtagtg ttaggagtag gaagagcttt aggtgaaaca atggcagtaa
     1681 tacttgttgc aggcaactca ccagttatgc caactgcaat aacagatagt gtaagaccac
     1741 ttacaactaa tatagcactt gaaatgggat acgcatttgg tacacatcaa gaaatgctat
     1801 ttgcaactgg agtagtattg tttacattta tattaatttt aaacttagtt ttaaataaac
     1861 tttcaaataa ggcggtaaat taagatgaga aagttcaaag agaatctatt gaagtcatta
     1921 gtatatctat cagcactatt tacaatagta tcattagtag ttatagtggg atttatattt
     1981 ataaagggaa ttggcaacat gaattttaat ttcttattta gcaattattc agcatcaggt
     2041 gatggtggta tacttccaat gataattaca acattatata cagtagtagt ttctatagtt
     2101 gtagcaactc ctataggaat attggctgct atatatttac aagaatatgc taaaaaagga
     2161 aaagcagtta cagctataag atttgcaact gaaagtttat cagggatacc atctatagta
     2221 tatggattat ttggaggaat tttctttgta gttacattaa aaatgggata ttccatagtt
     2281 gcaggttcac ttacagttgc aataataata ttaccagtaa taattcgtac aacagaagaa
     2341 gctttaaaaa cagttcctca agcttataga gaatcatcat tggcattagg agctacaaaa
     2401 tttcaaactt tatataaggt agtacttcca agtgcaatac caggaatttt atctggagta
     2461 atcttatcag ttggtcgtat aattggagaa tcagctgcaa tattacttac agcaggtact
     2521 gtagccaaga tgccaggtgg aatatttgat agtgcaagaa cattaactgt acactcatac
     2581 ttactgacta aagagagtgg agatatagca acagcagcca gtataggaat tgttttaata
     2641 gtaattgtat tagcactaaa catgctagca agatttgttg ctaagaaatt aaataaagct
     2701 aattattaaa tttaagaggt gtgaataatg gaattaatcg ataagataaa aatgagtgta
     2761 aaagatttgg atttatttta tggtgataag caagcattaa agaaaataaa tatggatata
     2821 aaagagaata aggttactgc tttaataggt ccatctggat gcggaaaatc aacttttata
     2881 agaacgttaa atagaatgaa tgacttaatc gaagatgtaa caattaaagg aaacatttct
     2941 gttgatggag aggacatata tacctcagat gatgttataa atcttcgtac taaagtagga
     3001 atggtatttc aaaagccaaa tccatttcct atgagtatat atgataatgt ggcatatggt
     3061 cctcgtacac atggactaag agataagaag caattagata aaattgtaga agaaagctta
     3121 aaaggtgcag ctatttggga tgaggttaaa gacaggctta aatcatctgc actaggactt
     3181 tctggtggtc aacaacaacg tatatgtata gcaagagcaa ttgctatgag accagaagtt
     3241 attcttatgg atgaacctac atctgcttta gacccaattt caacattaaa agtagaggaa
     3301 cttatagagg atttaaaaaa agactacaca atagtcatag ttacacataa tatgcaacaa
     3361 gctgctcgta tatcagatga aacagctttt ttcttaaatg gagaggttat agaatttagc
     3421 gatacaaaaa ctatgtttac cactcctgta gataaaagaa cagaagacta tataacaggt
     3481 agatttggtt aaaatatata actataaagg agttagacaa tggtcaataa tagcttagat
     3541 ataagtattg atactttaaa agaacaaaca gtgcttatga tggaaaaatg tgaagaagca
     3601 atagaaaagt ctgtgacttg tatgatagag aaggatttag agggtgcaag aaaagtagta
     3661 gaagatgatg aagaaataaa taaattaaga gaagaaataa gagataagag tatagagcta
     3721 atagtattaa agcaaccaat ggcaagggac ttaagattta tttattcatt aggtaatata
     3781 tctatagagc tggaaagaat aggagattat gcagcaaata tagctagaga aatgttgaag
     3841 ataggtggag aggcttatat aaaagagcta atagatattc ctaagatggc aaaagaatgt
     3901 aagtctatga tgtctcagac tagagaagct ttaatcttat ttgatgcaag tatagcttat
     3961 gatgttggaa ctaaagatga tattgtagat ggattgtatg aacaagtaca aattgattgt
     4021 ttaaaaataa tgcatgaaaa ctcaaatacc atagaccaag gggtaaaact tctacttata
     4081 ggaagatacc ttgaaagaat tggagaccat ataacaaatg tatgtgagaa gataattttt
     4141 gcaattgagg gtaaaatggt tgagatagga taaaaaactg ctttaaagca gtttttttat
     4201 tgtctaaatt aagaaagaat tgataaaaaa atatgattaa tgggtaaatt taaaaaattg
     4261 tgatatacta ggaacatatt aaatatgagg atgcgtattt tatataaggt gctttttagg
     4321 aggtggaact ttgaaacttc aaaagatggg tatgaggact ataaaaacag gaattagtgt
     4381 cactttatgt atgattcttg gtgactattt agtagagaat atgttttatt ctctggtagc
     4441 atgtataatt tctgttcaag atacagtaaa aggttcttta aagacgggaa tcaatagagt
     4501 ggaaggtact attttaggtg gtataatagg attcatattt gccatcatta aagctggaga
     4561 cccattttta tgtggtctag gagtaatgtg ctcaatatat ttatgcaatc tgtttaaaat
     4621 aaagtcagta gtagttgcct gtgtaacctt tctggctata catctaggtg taggaaatag
     4681 tgaccctgtg tattattctt tacatagggt gttagataca tctgtgggtg ttttgtttgg
     4741 agtacttgtt aattattatg ttgctagacc aaattatcta aatagtgtta tagatgagtt
     4801 taaaaagata gaagaacttt caatgttgct tattgaagat aaaattctta gaaaagaaaa
     4861 tttaaatgta gagaaatttg aagaagaagt agaaaaatta gaagaaatat attcaaaact
     4921 tattgatgag ttggattata gtttgagtga aactaatata gaaaaaattg agaatgcctt
     4981 aaggatatgt agagaaatac attttcatat gcagtctata gagttacttg aaaataaact
     5041 ttatttgaaa gagcatacat ataaatacct taagaaaaca tataatgtgg ataagctaga
     5101 ctggaatata gatgaagaaa aaagccctgt attcaactat catctaatga aaataatgat
     5161 tgaaatagag ttgttgagaa aactaaataa atcatattaa taatagtagt taaataataa
     5221 ataaaaaata gtatctttgt aaatattaaa catatataag tttaatttat ggaggtacta
     5281 ttttttatga atactagaaa tgacaattct aaaatactag aaatatataa aatgaagctt
     5341 tttggcgaac ttgtaaaagc agtgtggaat gatgacatag aggatattga aaacttacct
     5401 aataaaattt taaatgaaaa tttaaaggat aatttaaata attattttag tggaaaattt
     5461 gataaagata ctatggtaaa tttaattagg gtaactatgg gattggatgt gacagaagat
     5521 acagataaaa atttaaaaga gtcactacat gaagctgtaa atttagatga agtcaaaaga
     5581 ccaataatat ctgtaatatc agatgcttgc aaatattgtg atgaaaataa taaggaagat
     5641 gagtcatgta agataagaag taagcatatt aattgtaatg aggaagatgt atgtagtgct
     5701 tgtggtgatt gtgtatcaag atgtaagttg ggtgcaattt cagataaaat agaatttata
     5761 ccaatgataa aattgttaaa agatataaag agccctgtat atgcaatagt tgcaccagct
     5821 tttgtaggac agtttgggaa agatgtaagc cctggtaaat taagaactgc attaaaaaag
     5881 ataggatttg aagatatgat agaagttgct ttggcagcag atatgcttac tgcaaaagaa
     5941 gcatatgatt attatgagca tatgaaaaag gacgaagaag gatgctttat aactagttgt
     6001 tgctgtccta tttgggttag tttgatacaa aatagttttc ctcaaatatt ggagaatgta
     6061 tcaccatccg tttctcctat gattgcttgt gggagagctg taaaaatttt aaatccagat
     6121 gctaaagttg tattcatagg tccttgtatg gcaaaaaaga aagaggcaat gttagaagat
     6181 ataaaagatg cagttgattt tgtgcttaca tttaaagagt tgcaagaaat atttgatgca
     6241 ttagagttaa atccagcaat aatggatgag agtaatagag tagaggcgtc cctttcaggt
     6301 agagtttatg ctagaacagg aggtgtaagt aaagcagtta agttatcagt tagaagaatt
     6361 gacaaaaata taaaatttga agaaaaggca tttgaaggaa caaaagagtg catggacggt
     6421 ctaaagaaag ttctaaataa agaaatagaa gctacattta tagaaggaat ggggtgtgta
     6481 ggaggctgtg taggaggtcc gaagcgtatt ttaagtgtgg aagaaggtac taagaatgtt
     6541 gatgaatata gtgaaagtac gaatatggaa actccatttg ataatttaaa tgtattacaa
     6601 tttttaactt ctttgggaat caaaagagta gaatctttag gagaaaaaga agaagaaaag
     6661 gttaaaaaaa tatttagtag agatataaaa agtaataaga aagagaataa atataaaaaa
     6721 taacttttta agtcttaaac ttatgctttt ataaaaggga gatatggggg atgaaaatta
     6781 aagataataa ggctgttttt catgtattta taaggatatt tcttatagct gttttaattt
     6841 taactggaac attattggag gaaaaaatta ataatgttcc agttgaaaat ataagttcaa
     6901 aaggtgaaaa tacactggaa ctgctttctc aaagtaatac tttaggagaa atcatataca
     6961 aagcatctca agaagaaaca aaaggtccag gggctacttc tgaaaaagta gcatacataa
     7021 caatagatga tggtccatca aaatatacaa atgcactact tgatatttta aaagaaaatg
     7081 atgtcaaagc gacatttttc atgcttaatc agaatatgaa aaaccacaag gaagaagtaa
     7141 ggagagtctt ggaagaagaa aactcaatag gttttcatag tgtaagtcat gatatacata
     7201 agttatataa aagcccagaa gtaacagttg gggaatttaa tacatgcaat aatactctac
     7261 aagaaataac tggtcagagt tcaaaattaa taagattacc atacggaagt aaaccatata
     7321 tgccagaagg ttcatataat aaacttatgg caaatgatta tttaatttgg gactggaatt
     7381 tggatacaca ggattggaag tcttctacaa gtcagatagt aagtaatata ttatattatg
     7441 gaagaaaaag agatgaatta gtagtattaa ttcatgagaa agagcaaagt ttaaatgctt
     7501 taaataatat tataagaatc ttaaaagaga gaggatatac aatattgcca attacagaaa
     7561 atataacacc taaaaatttc tggcaagaaa acttataata aatttaaata tagtaaaaga
     7621 taaagtaaat tatttataaa ataaaacata taatataaaa aatacgaata agaggtatac
     7681 tgtaaggata atataaaatt aatgagaaag cattaaaatt aaaataaaat aatcttgcaa
     7741 ttattgacat tataagacag aataactgta aaaacatatt ttaaaatata acaactatat
     7801 aaaagagaat agacataatt aagaaaattc agaaaaaata aaataaaaat aattgacaaa
     7861 gagaataata tttgtatata ataatatgta atattaaaga ctgagaagaa gaggagtaag
     7921 taaatactac taaaagagag gaaaattcac tggctgtaag attttctaag tataagattt
     7981 actgaatgta gctttggagt ttctaaactg aactataagt aagtttagac ggttagaacc
     8041 gttaaattct ttgagagtca aagttgataa aataacatta accaataatt taatgatatg
     8101 ttaatgtatt ttaagctttg gaattaaggt ggtaacgcga gcttttcgtc ctttttaaag
     8161 aggatgaaga gctctttttt atttctaaag atatttaaaa aatttattta taaaatacag
     8221 gaggcaggac aatggaaaat acgaatttat caaaaactta taacccaaaa gattttgagg
     8281 ctaggctata taaaaaatgg atggatgaag ggtattttaa atctaaacca aatccagata
     8341 aaaaaccatt tacaataatg atgccaccac caaatataac agggcaattg catatgggac
     8401 acgctcttga ccatacactt caagatatat taatcagatg gaaacgtatg gatggatatg
     8461 aagctttttg gcttccagga actgaccatg cttctatagc aacagaagtt aaagttgttg
     8521 aaagaataaa aaaacaagaa ggcaagacaa agtatgaaat aggtagagaa gaatttttaa
     8581 agagagcctg ggaatggaaa gatgaatttg gaggaaaaat atctaatcag cttaaacaac
     8641 taggtgattc ttgtgattgg gataaagaaa gatttactat ggatgaaggg tgtaatgaag
     8701 cagttataga attttttgta agcctatatg aaaaaggtca catatacaga ggaaatagaa
     8761 taataaactg gtgcccagat tgcaaaacta ctttatcaga tgcagaagtt gaacatgaag
     8821 aacacgacgg aaacttttat catataaagt acccactaaa agatagtgaa gactttttag
     8881 aaatagctac aactagacct gagacaatga taggagatac tggtatagca gtaaatccag
     8941 aagatgatag atataaacat ttaataggaa aaacagcaat acttccatta gtaggaagag
     9001 aacttccaat agttgcagat agttatgttg atttagagtt tggaactggt gcagttaaga
     9061 tgactccagc acatgaccct aatgattttg aagtaggatt aagacataat cttgagcagt
     9121 taaatactat gaatgaagat ggaactatga atgaagtttg tggaaaatat gaaggtatgg
     9181 atagatttga gtgtagaaaa gctatcgtag cagacttaaa agaacaaggt tacctaatta
     9241 agataaaaga gcataatcat aatgtaggaa cttgttatag atgccataca gtagttgagc
     9301 ctagattatc agagcaatgg tttgttaaga tggaagaact tgcaaaacca gctatagata
     9361 ttcttaaaaa aggagaatta gaatttgttc cagataaatt tgataaaact tatttacaat
     9421 ggctagaaaa tataagagat tggtgtatat caagacaatt atggtggggt catcaaatac
     9481 cagcttatta ttgtcaagag tgtggagaaa tagtagttgc tagaaaaatg ccagataagt
     9541 gtcctaaatg tggaagcact cattttaaac aagatgaaga tgccttagat acttggttca
     9601 gttctgcatt atggcctttc tctactctag gatggccaaa taagactgaa gctttagatt
     9661 attattatcc aacaagtgta cttgttacag gatacgatat aatattcttc tgggtagtta
     9721 gaatggcatt tgcaggtatg ttctgtatga atgaaaagcc atttgaccat gttttggttc
     9781 atggattagt aagagattct caaggtagaa aaatgagtaa atctttagga aatggtatcg
     9841 acccattgga gataatcgag caatatggag ctgatgccct aagatttaca ttaacaactg
     9901 gaaattcccc aggaaatgat atgagattct atatggaaag agtagaattt gctagaaact
     9961 ttgcaaataa gttgtggaat gcatcaagat ttgtatttat gaatattgat gaagatataa
    10021 ttaaaaacat gactagagaa agtgttaaag aggacttaac tctagctgat aaatggataa
    10081 tatcaagagc aaataatatt gtaaaagaag caactaataa catggataag tttgatttag
    10141 gaatagcact tcaaaagata tacgatttta cttggtcaga atactgtgac tggtatattg
    10201 aaatggttaa acctagatta tatggagaag atgcaaatgc taaatctgca gcattatata
    10261 cattaactta tgttcttgaa aaaatattaa aattattaca tccatacatg ccatttataa
    10321 cagaggaaat atatactcat cttcctactg ttgaaggatg tataatagta tctgaatggc
    10381 caaaatataa tgaagaagat aacatggctg aagaagaaga tatgatgaac ttattgatgg
    10441 aaggtataag aagtataaga aatgtgagag cagaaatgaa tgtaccacct tctaagaaag
    10501 ctaaattgat aataatccca agtgaagaaa aaatagaagc tattgagctt ggtaaagact
    10561 attttataac tttagcatct gcttcaaatg tagagatagc aaaagataaa tctaatgttc
    10621 cagaagatgc agttggagta gttattgatg gtgttgaaat atttatacct cttaatgaat
    10681 tagttgattt tgaaaaagaa attgagagat tatctaaaga aaagaaaaag ttagaaggcg
    10741 aaataaagag agttaatgga aagcttgcaa atcaaggttt cttagcaaaa gctcctgaaa
    10801 gtttaattga agaagaaaaa gcaaaaaaag aaaaatttga agagatgatt aaatctgttg
    10861 aggaaagatt aacaaattta gaatctaaaa taaaataaat ataagaatta gtaaaaacat
    10921 acaaaaagta tatattctat actttttgta tgtttttctt tatatatata caaatatgat
    10981 gttataattc tttacagatg tgttatattt ttattttatg ttgtgaatat atgaatttta
    11041 tgtcttaaaa tttataagca ataaaaattt gatatattat gatgtttaat atagggtaat
    11101 aaatacatat tatatttatt ttactatatt tttttacata atatatctag aaaagtatag
    11161 gaatttatcg taatttaagt ttaaatatta aagagaattt ctataagtag tttaatcgac
    11221 aatttaaatt tataaagaaa tttaaatttg aaagctagtg agtacagttt ggaaattgaa
    11281 ataaagtaaa ctaaatgata ttttagattt ggaggtgata ttatgttcag ggtagttata
    11341 tgtgatgacg aaaaaataca aagaagcata ctaaaagagt ttacagaaaa acttttgtct
    11401 gaaagatgtc taaattatca aatactggaa ttttcctgtg gagaagattt aatatccaaa
    11461 tacccagaaa aaattgatat tatattttta gatatccaaa tgaaagatat caatggaatt
    11521 gaggtggcta aaaaaataag aaagtttgat gaaaaagtag aaattatatt tacaacggct
    11581 ttttcagagt atgcccccca aggttatgag gttcgtgctt atagatattt agtaaagcct
    11641 atagagtata gtaactttgc aatgggtgta aatctttgta ttgataacct tcaaagaaag
    11701 aaggagcgtt atatagtttt aaatagtaaa aaaggattta atagaatact gatagattct
    11761 attttatatg ttgaaactgt aaagagagat ttagtcgtac atacaatagg tagagattat
    11821 aaagctaata tgagcatgaa acaagcagaa aaattactgt gtgaaaatgg cttttttaga
    11881 tgtcatacaa gttttattgt taatttaaga agaatagaag atcttaggga taatatgatt
    11941 actattaatg aacaatttat acctataagt aagtatagac ttaaagattt aaaagtagca
    12001 ttaacaagct tgttatgtga tataatgtat taattttaaa aaggtaattg aaaatatcgt
    12061 aaaaaagatt taatgtcatc acagggctat tgattgaaac tgtcttaata tataaaatgt
    12121 tatttatatt aagacagttt tattatgcaa aatagcagtt tatagatttt taatatggtt
    12181 taacatgtat atgtagaggt tccattatag tagcatgatt attaattagt agcttgatta
    12241 tcaatatact attattgatt tttatatgca ttatatgtat ttttagaata tgattacctt
    12301 tttaaaataa tgattattta taaaactcta tagatatttg tttcatttag ctacgcatac
    12361 tttaattaat tatattaata tttaatggag tacaatataa atattaaagc gacatcttat
    12421 agtttattga aactatagta atgaattaat aaatagttta attctatgaa aagatttcct
    12481 tttatgcaat ttatttattg aaatatgata taatatataa aggtgtaagt attagttgtt
    12541 aaaataatat ttatattagt ttttatacat acttggtata agtttttcat atattgatta
    12601 aaattgatgt tgatttatta tttttagtat tttttcacct tttgattcat actttgtaga
    12661 atggtgtatt ttctaaaact gattataaga caagttcatt caaattagca tttttatatc
    12721 atataaataa ttgttccccc taaataagat ttagatgtat agtattaaaa tcaaaaagta
    12781 taaaataaaa ttgatgctta atcatagata aatattaata aaatatacaa ggggattgtc
    12841 taataaaaag ataatctcct tttttacaaa taattctaaa ttgtgatata aatctaaaaa
    12901 ttttatctta acatttaacc atttaatgat aataattgat ataataaata taaattaaat
    12961 atatggtgta cttattttat gtttttagca agaaatatag catttaaaag ataaattgtg
    13021 caacttaaat caaagtttaa gatgaactat taacatagat atattaaaaa cttttgtaat
    13081 ggagaatata tgtgatatga ataataaagt taaggttgca gtattagata caggaataga
    13141 caaagaacat gattacttaa aagataattt agttggagga attgcttttg aatgtatgca
    13201 tgattatatc tttatatcag ataaatttga tgatgaagat ggtcatggaa ctgcttgtgc
    13261 atcaataata aagaaagagt atgaagatgt agagttattt gtaataaaaa ttttgagaaa
    13321 agatggtatt acaaatataa aagttcttga agaagcatta agataccttt tagacactaa
    13381 cataagatta attaatttaa gtttatcagt cataggagta gaaagtgtta agggcttatt
    13441 tgaagtttgc tatgaattgt ttagaaaagg aaaaataata gtatgttcac tcgctaatga
    13501 ttttgactta agttatccag ctatgtttaa caatgttata ggtgtaagag gatttacttt
    13561 agatggagat gattcatttt ggtacaacaa aaaatatgat gttcaatgtg ttatggatag
    13621 caattcatat ataagttgtg atataaataa ttcctataga ttaccaccaa aatgtaatag
    13681 ttatttatca gcaaagctta ctggtaaaat agctaagata ttatcagaaa aaccaggcat
    13741 aacaatatct gatttaaatg ataagcttga atcattagca actagaaatc attgggatag
    13801 ttgtgatttt gatgagtgta gtagaattgt aaactttaaa ttggatttgt atgacaaaga
    13861 aaatgctctt tttatgaaag ttgctgacgt tgttagggat tgcttagata ttgaagagaa
    13921 taatgaaaaa ctctttaagg gtagcctttt taataaggag ataggcttgg tttatgataa
    13981 ttgttttaat ctgttgaaaa agctagagca tagatttgac ataaagttta attatatgga
    14041 catctcaaaa tatgacttag tttcaatata tacactgact gaattagtgg aaagatataa
    14101 aaacttataa ataaagattt gtagctaaat ttaatgtaga aggtattaaa ttatatgtat
    14161 tctttgtcgg tagattaaaa gtaaaaaata tactataatt agatagcata agagaaaatg
    14221 ccaatacagg gggagttaga taatgaaata tgaagaagca ttagagtaca tatcacaaac
    14281 taataaattc ggtataagat taggattaga aaatatcgga aagttattag aattattagg
    14341 aaatccacaa gaaactttga atataataca tgtagctgga actaatggaa aaggttctgt
    14401 gtgttctttt gtttctaata tactaagaga gtgtggatat aaagttggtt tatatacatc
    14461 tccatattta gaaactttta ctgagcgtat aagagtaaat ggacaaaaca taccacagga
    14521 tgatgttgct agaataattg agttaataaa agaaaaaata gagattatgg taaaagaagg
    14581 ctatgcatat ccgacagaat ttgaagtggt tactgcaatg gcattttatt actattcaga
    14641 acaaaaggta gactttgtgg cattagaagt tggtttaggt ggcagatatg atgctacaaa
    14701 tataataaca aaatcacttg taagtgtgat agtatctata agtttggacc atacaggtat
    14761 acttggagat acaatagaaa aaatagcgta cgaaaaggct ggaataataa aggaaaatgg
    14821 agtagtacta gtatatgacc agactgatga agcaaaggat gttataaagt cagtttgtaa
    14881 agagaaaaaa gctaaatata tagaagttga ttttgatgat ataaacataa aaaaatcaga
    14941 tataaattct caaatatacg attgtactgt aatgaaagaa acttatagag accttgaaat
    15001 aaaattgata ggcgaacatc aaataaacaa ttctatcttg gcaattagtg taataaaata
    15061 tctaaaagac ataaataaat tagcaaatat aaatgaagaa tctataagaa aaggacttat
    15121 aaatactaaa tggccaggaa gaatagaaaa gataaaggaa aatccaattt ttataataga
    15181 tggtgcacat aatgaagatg gagcaaaatc tttggcaaaa gcacttgata agaattttaa
    15241 aggtagaaaa ttaaccttat taataggtat gttagaagat aaagatattg atagtgtttt
    15301 agagatattg ttgtcacatt ttaataaggt aataacaaca acaccaaata acccaagggc
    15361 cataaattca gatatattaa gagaaaaagt attaaaatat gtagatgatg taacatcaaa
    15421 gcatgagata gaggatgcag taaattatac attagaaaca tcaagtgagg atgatattat
    15481 aataagtgca ggttcattat atatgattgg tacagtgaga actttagtaa agaaattata
    15541 attttataaa ataagtatac aaataaaaat ataaaaaaga gttgtctaaa aaatggacaa
    15601 ctctttttat ataaaataag tttttaataa ttttactgat gtttatataa gtaattatat
    15661 agattgacgt atagctttag ataattggtc tgggcaagaa gtaccttttc caccacagtc
    15721 aataccattt aatttatcag caacttcaag agcattttgg ccaattatta agcttctaag
    15781 tcctgataaa ttaccattac atcctcctat aaactcagca tcaacaatca cattattttc
    15841 atcaacttca aaaatcattt ctctacaaca tacaccactt ggattaaatg ttactttcat
    15901 taaaaagacc tccattaaat attatttctt tttttaacat taataataat accaaatata
    15961 tgcgtaataa tgcaactata aagcataata caagctaatg aaataatata ttattgtagt
    16021 atatgtattg tagagaggag gggttatatg aaaatctata tttctaacta cttatcaaag
    16081 agtattagca tagttgatta ttctacactt gaactagaaa aagaaatagt attagaagat
    16141 aatatatatc cacaccattt ttgcatagaa aaagaaaaaa atttaatata catacctagt
    16201 tcaagtaatg ggatactcta tgtcttagat ttaagtaatg ataaaataat tgatactgtc
    16261 tctataggag gaagtcttag tcaagttgta cttagcgata atgaattgtt tgtggcaaat
    16321 gaagattcta atagtatata tgtactagat aaaaacacat taaatccaat aggaattatt
    16381 ggagttgata atatgccaca tggatttgac tttgatagag aaagcaaaaa gttatatgta
    16441 ccgtgtataa actcgatagt atgtatagat acaattaata aaaatataca aaagaaaata
    16501 aatatggact ttagagcttg gcatatagaa cttgataaac aaaagaaaga aatgtatata
    16561 tcaacacttg atggaaagct tataataata gatgaagtaa gcatggatat aaaaaaggta
    16621 ttatatgaat ttttattacc agtagaaata agatttaatt atagtggcaa aaaagtttat
    16681 gttgctgatt tgggttataa taatgtaaga attttagatt atacaacgag tagatacatt
    16741 ggaaatattg aaataaatgg gattccccaa ggattagaaa tatctaaaga tgaaaagtta
    16801 ctatttgtat cagatacaca agaaaattca gtaaaagttt atgaaactgc aaataacaaa
    16861 ttaataaaag aaatcaaggt aggaaaagag cctacaacta taatttgttt gtaggcttta
    16921 atgtatgtct cttataagta aatcgataac ttcggcatac atataagatg cattattttt
    16981 ccagttattg caaataagtt ttgcttgttt ctctgatgaa acatttagat ttaaatctat
    17041 taagttagac tgattttcta tgactctaag gttgacaata aattcattat cactttgttt
    17101 tacaaaacta gactttactt gagtatctgc tagtagattt tctttgttag aatctatata
    17161 cttgtctatt ttttcagtaa cactagtagg tattcgatta aagaagtatt ctagactttc
    17221 tacgcctctt tgagtaagag cataatattc tctgtcagag tctttatatg tagtcaaaaa
    17281 cttagattcc ataagctgag ataaaagctg ttgtaatgaa aaataattca tcatctcagt
    17341 ctctaatact acttgagtta tttgagaatt agttaaatcc attttaattt tttctaatat
    17401 atataaaatt aaaagtttgt gataggctaa ttcttcagac gagttttcaa acataaatat
    17461 catcctccgt caaactattt ctatatataa tatattaaac taatttgtac aaaattaaaa
    17521 gaacaatttg tattgtatta ttaatcttta ataattcata taaaaacaat tttataaata
    17581 aatatagaaa aacagggctg ctaattagca gccctgttga tacccaggtg tcaaaattta
    17641 ctatttattt tccagccatt tgtctttcag ccatttcaac taatttctta gtcatatatc
    17701 caccaacata tccattttct ctagctgtta agttaccttt gtctatgttt tcatagttag
    17761 ataaacctat ttcgttagct atttctaatt tcatttggtt taaagcagct tttgcttctg
    17821 gaactactgt tctgtttgaa tttgacatag taaatttcct cctcaaataa ttagtttatg
    17881 atgtctaaca acacttttat ttatgtgatg ttaatactaa tttctccaaa ataaaaataa
    17941 tatatacaga aaaataaagg taaaaatgta aaaaatataa aaaaattaaa taaatgagta
    18001 ttttagagag tttaattagg tcaatatagg ttttattttt ttagttattg tcttataaat
    18061 taaatattac agtacttttt tgagctgaaa aaaaataaat tttaaatata gaagaaatta
    18121 tttcaaaggg ggaatagtat gaaaagagaa gttaaaagga ctaaagcttt gatatatagt
    18181 gttttatttt tttcattatt attagtgtta atatttgttt ttgtttatgg aataaaatac
    18241 atatgttcta aatctgacaa ttcaaaaatg cctatatata aagttgatac aaatgagaaa
    18301 aaaatagctt tgagttttga tgtagcatgg ggaactgata atatggatga tattttaaaa
    18361 attttagata aacataatgt aaaagctacc ttctttttag ttggtagttg ggtggatgat
    18421 aatgaagaaa ttgtaaaagc tatagatgaa aaaggacatg aaattggaaa tcattcaaat
    18481 actcatgcca atttgaagga aatatcaaaa gaagacataa caaaagagat agaaactaca
    18541 tcagaaaaaa tatataatat aacaggaaaa aggactaatt tatttagacc tccttttggg
    18601 gacgtaaaca ataaagctat ggacatttgt agtgatttag gttataaagt aattaagtgg
    18661 gatgtagatt ctatagactg gaaggagctt ggaccaaatc atgtaattga aaaagtaata
    18721 aaagaatctc aacctggttc aatagtttta ttccatgcta atataaatga tgtagataac
    18781 tatttggata ctataataag tcgactaaaa aaagatggat acagtctagt caaaatatct
    18841 gatttgttgt ataaagataa ttatgtagtt gattccaatg gagtgcaaaa aactaagaat
    18901 taataagtaa taaatgtata ttttaagtaa agttgtgata aattatatag tatatgttag
    18961 aaaagtgtcg ataaaaagac ggtgtctatt ttttgacact ttttatacat gtatgcaata
    19021 tcaataatta tagattaaat tgattaaaaa agtgtctaat aattgacttt tttttgatgg
    19081 gtttaaaaat ttagaagaat taatgaatgc tgtaagacag tatttccaaa gggtataagt
    19141 ttgtttaaaa gttggcatag aaattgcttt gttaataagc gatatgttct atagaaataa
    19201 acaatatgtt aagaccttat aatagaaaaa tagcattaac attatttgaa cagcttataa
    19261 aaaaattaat atacttaagg gggcgtacta gttgaacaaa ctatattcta ttttattaaa
    19321 acaacacgtt ggtggtccag ataagccagt agtaagtgtt ggagatgtag taaaaaaagg
    19381 aactctaatc gcagaaccaa ctggattagg ggcaaatatt tatgccagtg ttagtggaaa
    19441 aataagtgaa ataaatgacc aagcgatagt aattgaagct gatgaagtac aagaagatac
    19501 ttttgaacca ttaaaaggag aaggtatact tgacttaatt aaagaagctg gagtagtagg
    19561 aatgggtgga gcaggattcc ctactcatgt aaaattaaac atagatttaa atggtggaac
    19621 aatattagca aatgcagctg aatgtgaacc tttattagct cataatataa aagaaataga
    19681 agaaagacca gaaatagttt atcaaggtat aaaatatgct atggaagtta ctaatgctgg
    19741 aaaaggtatg ctagcaataa aaagtaagca tccaaaagca atagaagctt tcaaaaaagt
    19801 aataaagcca ggagacaaca tagaagttgc agaactagtt gatatgtacc caatgggaga
    19861 agagagagca atagtaagag acgttctagg aaaattactt gagccaactc aattaccttc
    19921 agaggctaat gcagtagtaa taaacgtaga aacactaact agaatagtag aggctgttga
    19981 gcaaaaaaga ccagttatat ctaaaaatat aactgtagtt ggtcaattaa acagtggaaa
    20041 agaatctata gtgtttgaag atgtgccaat tggaacaact gtcggagaat taattgaaag
    20101 agctggtgga ataaaaggtg aatatggtga aataatccta ggaggacctt tcactggtaa
    20161 agctactact ttagatgctc caataactaa aactagtggt ggtataatag ttactatgcc
    20221 atttgttaat gaaaagagaa aaatgggtct tttagtttgt gcatgtggac ctaatgaaga
    20281 aagaatgaga gatatagcaa ctaaaatggg agttactgat atagtatcag ttcaaaaatg
    20341 taaacaagct caagaaatta aaggtgcatt aaaatgtgaa aatccaggac actgtccagg
    20401 acaagctcaa aaatgtattg aatttaagaa agctggagca gaagttatat taataggaaa
    20461 ctgtactgac tgtagtaaca cagtaatggg ttctgcacca aaattaaaat taggtgtata
    20521 tcatattact gaccatgtaa tgagaacagt taatcaccca ttaataagaa gaataaaagg
    20581 tgacgtaaga ttaaaaataa aataatagat aaatagaagt tagacatctt tagaagtaaa
    20641 acttaaaagt tacttctaag gatgtttttt aatgtatttt gagggcaata tatatattgt
    20701 aaaataaatg gaaaaaatag acaaaatatg ctagatattg tataatgata ataatagcta
    20761 ttacaattaa tattggacaa aaataatgat actcaagtat gtggtttgta ttaatatgca
    20821 tattatatta agtcaactat ccgatagagt aaaaggtttt tgtgatattt gaagatactc
    20881 tatagtatct tttttattat aaaaactaat ttttgtcttt tattagataa gtatctagga
    20941 tactaattta tattttattg agttgttaaa aaagtgcact taaaaagtta aaaaagaaaa
    21001 attaaaaaac ctatttatag aaactgtgaa gtatatctta aacctgggca cttaaaagat
    21061 atatggagtt agtagtgcaa cctgctataa atataaatag gagtaacttt taattgtcaa
    21121 aaatatataa aataaataca taaataagta attaatagaa gatagatata aatatatttt
    21181 tgaaatgctc cctgcattca taacgagtgt agagtggcag atatctgccc aaaactcctt
    21241 taattgctgg aagttcctaa agctaactaa accacaacat aatcatgaaa taaggataag
    21301 tgtgatagag tgtgcattta ataagcactt gaggttacga aagtagaaaa aattagttag
    21361 atagcataag gttaaatcct aagtgccttg aaaatggata atcagcaggt aagcttcgaa
    21421 aagaagaaac ttcaacgact agagagaaat ctcgtaccta caagtgtggg gaaatgggga
    21481 gtacctaatt tatggttagg taatgatata gtctgtgctt aatagaaata ttaagaagtt
    21541 cataggagaa ctggttagga gtaacgaccc taattgaaca cactaaagat gtattattga
    21601 ataagattca tataatattt aataatttta attatattaa gtgaatacaa tatatgtttt
    21661 tagtatcagg agaattttga aaacaaaaat taaaaaatca agtataatca gtttagtaat
    21721 tgcttttagt atggtgttta ctgcatttac accaatagta tcttatgctg acgaagtgac
    21781 tagcaatgat acaatactta atggagaaga acaatcaaat ggtcagacac cagatgtaga
    21841 gaaaccatca gacggtcagg taccagatgg ggagaaacca tcagacagtc aagtaccaga
    21901 tggggagaaa ccatcagacg gtcaggtacc agatggggag aaaccatcag atggtcagat
    21961 accagatggg gagaaaccat cagatggtca gataccagat ggagagaaac catcagatgg
    22021 tcagatacca gatggagaga aaccatcaga tggtcagata ccagatgggg agaaaccatc
    22081 agatggtcag atgccagatg gagagaagac atcagatagt cagacgccag atgtagagaa
    22141 accatcagat ggtcagatgc cagatgggga gaaaccatta gatgagcaaa ctccagaaga
    22201 agaaaaacca ttggaagaag aaatagttat agaggaaatg agtttaaaac aagatattga
    22261 taaaattctt gatatgactt tatctcaaat aaataaaata gtatataact tttgggaaga
    22321 tgaagaagat gtaaaggcag atgaacaatc agaaattaac caagttttta cttcagaaga
    22381 ctcatttatt agcttatggt atgacaaaaa agcaaaagta aaaaattctt gtttactaaa
    22441 agaaatagat ggttcagata gaccttatca tgatttaaga tttgatgata ttacaaagac
    22501 tttaactttt gactatgtaa taaagggtct tgtaggagca agctcaaaag acgacaaata
    22561 tgtaatagaa ggtgaagatg gagagcaaac tgcattttgt tacaataatc atttaagacc
    22621 accaagtagt aatggaaaga gtccatattt accagcagaa gattttaatg gtcaagaaaa
    22681 ccaaaatgaa gaagcagtta aatctatact atatgcaggt tctgaatttg atggatttgg
    22741 atataagcaa caatttaatt taggtggaga agaaaatgaa ttgatgactt actcagctac
    22801 tcaaagtgca atttggatta ttcttggaca aatggatgaa caagaaagac ttaagcagta
    22861 tcaaggttct ataaaccttt gtgataaact tatagaaaga gcaaaaactg aagaggaaag
    22921 agctgagtat cagaagaaga aagaagtagc tataaatata aaagcttatt tagaagcatt
    22981 gttaaaagca ggtcgtgaag agttaaagcc aaatgataca ggaaaaccta gtttgagtaa
    23041 tggtttaact aagattaact ttgaaaaaaa tgaagatggt acttatgaaa cagaagctgt
    23101 agccttagta ggttatagtg gtgtagtaaa gttaagacta ccagatggag taactgctta
    23161 tgatggagat ggtaatataa taggtacagg tgaagtagaa atttcaacac aacagaaatt
    23221 taaacttaag agtgttgtaa aaccagatgc caaagctaat atttctgctg tatcttatga
    23281 ttatattttt ccaaaagcta ttcaatatta taaggcagtg cttgatttag gacaaaaaga
    23341 ccattcatct tcattaccat ctagtaagca aaatttatta agttatacaa tagagaaaaa
    23401 aaatggtcaa gaagttaact ttaatatagg tctaccaaca gatgatgttg taaatccacc
    23461 agtgccacca acagatgata caaatggaca taagccaaaa ccatcaccac caatagatga
    23521 tacagtaata aatccaccag taccaccaat ggatgataca ataataaatc caccagtacc
    23581 accaacggag gatgcagtgt taaatccacc agtgccacca acggaggatg cagtgctaaa
    23641 tccaccagtg ccaccaacag aggatacagt gttaaatcca ccagtaccat cagtaagtga
    23701 tacagtggaa aaaactccag aactatcaag agatgataca ataataaaat caccaaaaac
    23761 aggtgatgaa actcagctaa tgtcatatgt atttattagt gtcattgcaa tttgtggatt
    23821 agcgtatcaa tgtaaaataa aaagaaatta atctagatta ttattaagtt taaaataaaa
    23881 agtctcaaat tgatttataa gtcattttgg ggctttttta tgtaaatata atatgcaaat
    23941 atagtttgtt taaaaatata tattttaatt atattcttaa atttatgatt ggatacaggc
    24001 attcattaat tgtttgatga atagaaaaat gttttgaagg tgaaaatagt attgaaaaaa
    24061 taatatacta agggtataat tcatttgatt tcatttgtat aaatttaatt ataaatttta
    24121 aagtgattat ataaatttaa atgctaatta cttaataaat tttaataata attatttaat
    24181 aaataattat tataatatgc tagaataaat atatataaat aagttttgat gaggtactac
    24241 tataaagggg ggactttatg ttttcgatac cagaagtaaa aaaagtagaa gaggtaatgg
    24301 atacaaaatt tacaactata gacgaagaca caagaattga agatgcaata aaagaaatga
    24361 taaaaagcaa cacaaaaact ctaatggtaa tagattcatc tgaccaatta aaaggcatta
    24421 tatccatgac ggatatacat aatctttatg agatgcataa aaagtatgaa ggtcaaccag
    24481 taaaacttat aatgaagaag gatgtaatat atgtcaacga aggtttaacc ttagatgaat
    24541 gtagagatat aatgatatta aaaaatatag ggattcttcc tgttcttaga gataataaaa
    24601 ttattggagt tctaaaacaa gagcacatta gggactatct atatatgcat ttagaagatt
    24661 atggattaac tttgaagtat attataggtc aaattaaaga aggaatttgt gctataaata
    24721 acgaaggtgt tgttatcttg tggaataagt ttatggagga aaggtatgat ataaagtctg
    24781 aagatatagt tggtcgaccg atgaatgaat ttttggaaaa tactatttca gaaaaagtac
    24841 taaatagtaa agttggaatg agtgacttgt attttacaga taaaaaagaa aatatgtatg
    24901 cattagttca tgcaaatcct atattttata aagaagaatt tatcggtgtt gtatgtacag
    24961 aagttgatgt tacagaagct aagatattag ctcttgaact tgaaaaagta aatgatacat
    25021 taaaatatct aaagaacgaa gtcaaaaatt tatctaaagg tagttttgat aagattttag
    25081 gtaaaagtta taaattggaa aaatcgaaag cgattgcaaa acaagtggct agaacaaata
    25141 gtagcatatt tatttggggc gaaagtggta caggtaaaga agtatttgca agagctattc
    25201 atgattatag tgagagaaaa ggtcaattta tacctgttaa ctgtagtgcc ataccaaatg
    25261 agttatttga aagtgagttt tttgggtatg aatcaggtgc gtttacagga gcaagtaaaa
    25321 agggtcgaat aggtatattt gaacttgcaa aagatggaac tgtattttta gatgaaattg
    25381 ccgatttacc tcttagtatg caagcaaagt tgcttagagt attacaggaa aaagaaataa
    25441 gaagagttgg tggagatacc acaataaaaa taaatcctag aataatatca gctaccaata
    25501 aagatttgag taaaatggta aaggcagaaa aatttagaga agatttatac tatagattaa
    25561 atgttgttga aataaagatt cctccactta gagagagaaa agaagacata ggattattgg
    25621 ttcatagctt tttagaggag atatgtaaac aaaataataa gcctgttctt acaattagca
    25681 aagatgtaat agatatattt cagaattata gatggaaagg taatattaga gaattaaaaa
    25741 atacgattga aaatattgtt gtattgtcac aaaattctaa aatagatgtg gatgatgtac
    25801 caagttatat gatggattct acaaataata gtactgaaga agaagagtat cctttagatt
    25861 taacgaaggc aactcaaaaa attgaaataa agaatataac caaggcactt aaaatgtcta
    25921 atggaaataa agctaaagca gctaagatat taaatatacc cagaacaact ttgtattata
    25981 agatagacca atacaaaata gatgtgtcta aaatatgaca catgactaaa ttttgacaaa
    26041 atgataaact ttaatttaaa acctagtaaa gccaacgctt atataagtgt tgtgtatata
    26101 gatgtgttaa aaaaaatgaa aaagtgttga ttaattgaca ctttttttgt ttgagaaaat
    26161 gtttacaaat acaaaaaata acatatttta aataaatatt tatataatat ttggctaaaa
    26221 atagcgatag atgaagaatc tattatagaa aaaatctttt tgttaataag ttggcatagg
    26281 aattgcttat aatataaagt gactttaagt gagaaaaaaa taatattaat cataacaaat
    26341 tatgtaggtt ttaatttact taatttctca gttaaggggt tacctgttga ggaattgaga
    26401 tttaaaataa taaataagaa aataatgtaa ggaggtattt tatactatgt caataacttt
    26461 agaaacagct caagcccatg caaatgaccc agcagtttgt tgttgtagat ttgaagcggg
    26521 aacaattata gcgccagaaa acttagaaga tccagcaata tttgcagact tagaggattc
    26581 tggattatta acaataccag aaaatggatt aactataggt caagtactag gagctaagtt
    26641 aaaagaaact ttagatgcac tttctccaat gactacagat aacgtagaag gatacaaagc
    26701 aggagaggct aaagaagaag tagtagaaga aacagtagaa gaagcagctc cagtatcaga
    26761 agcagcagta gttccagtaa gcacaggagt tgcaggtgaa acagttaaaa tacacatagg
    26821 tgaaggtaag aacataagct tagagatacc tttatcagta gctggtcaag caggagttgc
    26881 tgctccagta gcaaacgttg ctgctccagt ggcaagtgca gcagcagaag tagctccaaa
    26941 agttgaagaa aagaaacttt taagaagctt aactaaaaaa cactttaaaa tagataaagt
    27001 tgaatttgct gatgaaacta aaatagaagg aactacttta tacatcagaa acgcagaaga
    27061 aatatgtaaa gaagctaatg aaactcaaga gttagttgta gatatgaagt tagaaataat
    27121 aactcctgat aaatatgaaa cttacagtga agctgtatta gatatacaac caatcgctac
    27181 taaagaagaa ggcgaattag gttcaggtat aactagagtt atagatggag ctgtaatggt
    27241 attaactggt acagatgaag atggagttca aataggtgaa tttggttctt cagaaggtga
    27301 gttaaatact actataatgt ggggtagacc aggtgctgct gacaaaggtg aaatattcat
    27361 caaaggtcaa gtaacaataa aagcaggaac taacatggaa agaccaggac ctttagctgc
    27421 tcaccgtgca tttgactatg taactcaaga aataagagaa gcattaaaga aagttgacaa
    27481 ctctttagta gttgatgaag aagtaataga gcaatacaga agagaaggta aaaagaaagt
    27541 tgttgttata aaagaaataa tgggacaagg tgcaatgcat gataacctaa tattaccagt
    27601 tgagccagtt ggtacattag gagctcaacc aaacgttgac ttaggaaaca tgccagttgt
    27661 attatctcca cttgaagtat tagatggtgg tatccatgca ttaacttgta taggacctgc
    27721 atcaaaagaa atgtcaagac attactggag agagccatta gtaataagag ctatggaaga
    27781 cgaagaaata gatttagtag gtgttgtatt tgttggttct ccacaagtaa atgctgagaa
    27841 attctatgta tctaagagat taggtatgtt agttgaagct atggaagttg atggagctgt
    27901 agtaactact gaaggtttcg gaaacaacca tatagatttc gcatctcaca tagagcaaat
    27961 aggtatgaga ggtataccag tagttggtgt aagtttctca gctgttcaag gtgctctagt
    28021 tgttggtaat aaatacatga ctcacatggt agacaacaat aagtctaagc aaggtataga
    28081 gaatgaaata ttatctaaca acactttagc tccagaagat gctgttagaa taatggctat
    28141 gcttaaaaat gctatagaag gtgtagaagt taaagctcct gaaagaaaat ggaatccaaa
    28201 tgttaaatta aataacatag aagctataga aaaagttaca ggagaaaaaa tagtattaga
    28261 agagaatgag caatctctac caatgagtaa gaagagaaga gaaatatacg aaaaagacga
    28321 aaactaaaat ttagatacta actaagattt agacaataac ataaatttag atccaagttt
    28381 aaaacagtat agagaggtag aattataatg gataggttaa aatatatctc atcagagact
    28441 ttttatgaag gtattatagt tgacatcaaa ggcggtggag tgactataga cctaaaaggt
    28501 agacttggac aatttaaaat acctaataga atgcttataa ctgactacga acttaagata
    28561 ggtcaagaag ttggattcat gctaagctat cctgaggtat taagtccaga gcctaatcaa
    28621 gagtatgtag aaaatattag gagagaaaaa gaaaaacaag cagaaatgca atcaaaacaa
    28681 gaagaaaaat aataaataat cgtttgaaaa tagaagggag aggaaatata tgagccttac
    28741 aacagtacaa ggacttcaat ctgaaatatt cgttccaata acacctcctc cagtttggac
    28801 tcctgtaact aaagaattaa aagatatgac tatagcttta gctacagcag ctggtgttca
    28861 tttaaaatct gacaagagat ttaatctagc aggagatact acatttagag ctatacctaa
    28921 tacagctaca gttgatgaaa tgatggtatc acatggtgga tatgacaatg gagatgtaaa
    28981 caaagatata aactgtatgt tccctataga tagattacat gaattagctg cagaaggatt
    29041 tatcaaagga gtagctccta tgcactatgc attcatgggt ggtggaggaa accaacatgt
    29101 cttcactgaa gaaactggtc ctgctatcgc tgctaaactt aaggaagagg gagtagacgg
    29161 tgtagttatg acagctggct gaggtacttg ccatagaact gccgtgatcg tgcagagagc
    29221 aatagaggaa gctggaatac ctacaataat aatagcagct cttcctccag tagttagaca
    29281 aaacggaact cctagagcag ttgctccatt agttccaatg ggtgctaatg ctggtgaacc
    29341 acataatata gaaatgcaaa cacatatatt aagagataca ttagagcaat tagttgcaat
    29401 accatctgct ggtaagatag ttccattacc atacgaatat aaagctcacg tttaaaatgt
    29461 aatttatatt tgaaaatata gaacccttct cctacacggt taggagaggg gttttaagaa
    29521 caaaggtgga tattatggaa gaaaaaataa tgagaagact tgttataaaa ccgtttcata
    29581 tgaatgaagt taatttcggt tcaaaaactt ctataaagaa agatgtactt acaatagatt
    29641 tatcaagtat agatgaaata aaagaaagag aagagttaat aacagacata aaagtagaca
    29701 ttataaaacc tggagattat gacagagaaa ttaatactat tatggacatt ataccaatat
    29761 caacaaaagt tttaggcaga ctgggagagg gtattacaca tactttaacg ggtgtatatg
    29821 taatgttaac tggtgcagat gaagatggaa atcaaatgca tgaatttggt tcttcagaag
    29881 gaattttgaa agaccaaatg gtatttggga gatatggaac tccatcagtt gaagattata
    29941 taatccatgt agatgtaact ttaaagggag gtttaccttt tgaaagaaca cttccacttg
    30001 cagcattcag agcatgtgat gattttatac aagaaataag agcgtctttg aaaatggaag
    30061 acggaagaaa tgctactcaa gttcgtgaat attttgacaa aattcgacca aatgcaaaaa
    30121 aggttgtcat agtaaaacaa atagcaggtc aaggtgctat gtatgacaat cagttattct
    30181 caaaggaacc tagtggattt gaaggaggaa catcaattat agatatggga aatgtaccta
    30241 tgattatatc tcctaatgaa tacagagatg gtgcccttag agctatgact taagagaggt
    30301 ggatattatg ggaataggac cttcaacaaa agaaacatct cttcatcact ttagagaccc
    30361 acttttagac atagttgaaa gtgataagga tgtagattta cttggagtaa tagtagtagg
    30421 aactccagat ggaaatgaaa ataaaacctt tgtgggacaa agaacggccg cttggctgga
    30481 agccatgaga gtagatggag ctatagtttc atcagatggt tggggaaact cacatgttga
    30541 ctacgctaac acatttgagg aaataggaaa aagagatata cctgtagttg gagttacatt
    30601 taatgggact caagctaagt ttgttgtaag caatcaatat atggatacca tagttgatat
    30661 gaacaaatca aaagaaggta ttgagacaga agtagttgga gaaaacaaca caaatgaaat
    30721 agatgctaaa aaagctttgg catttttaaa acttaaaatg agaaaacatg gataaaaaat
    30781 ttaagtaagg gaatgagttt tgtgggaatt tctacatcaa tgaaaaacac atcacttcat
    30841 atatttagag acccgttact agatttgata gataatgatt ctgacataga cttgttagga
    30901 gtggttgtag ttgggacatc agagcacaat gaatggaaaa catttttagc aactagactt
    30961 ggaagatgga ttgaatcatt gcgacctgat ggagtgatta taactttaga tatggcagga
    31021 aaccagcata ttgattttac aaatgctata gcagagtttg taaaatcaga tatacctaca
    31081 gtaggtctta ctattatggg agcagatgga ttagtaatta ccaatccata tttggataaa
    31141 gctaccataa ttgattataa aaagacaaca ggctacatag aaacagaagt agttggagac
    31201 aatcacatgg atgaagttga tgttaaaaaa gcattggctt tcctaaaatt aaaaatgcgt
    31261 aaagacgcaa aataaaccta agggggaatt tgatatgaaa tttagcagaa gtatacaagc
    31321 tatagactct catacagcag gtgaagcgac tagaatagtt gtaggtggaa tacctaacat
    31381 aaaaggaaat tctatgcctg agaaaaaaga atatttagag gaaaatctag attatttaag
    31441 aactgctata atgttagagc caagaggaca taatgatatg tttggttctg taatgactca
    31501 accttgttgc ccagatgctg actttggaat aatcttcatg gatggtggcg gataccttaa
    31561 catgtgtggc catggtacaa taggagctat gacagcagct atagaaacag gtgtagttcc
    31621 agcagtagag cctgtaactc atgtagttat ggaagctcca gcaggaataa taagaggaga
    31681 cgttacagtt gtagatggaa aagctaaaga agtatcattc ttaaacgtac cagctttctt
    31741 atataaagaa ggtgttgaag ttgacttacc aggtgttgga actgttaaat ttgacatatc
    31801 atttggtgga agcttctttg ctataataca tgcaagtcaa ttaggtttaa aaatcgaacc
    31861 tcaaaatgct ggtaaattaa ctgaactagc tatgaaactt agagatataa taaatgagaa
    31921 aatagaaata caacatccaa ctttagctca tataaaaact gtagacttag ttgaaatata
    31981 tgatgagcca actcatccag aagctactta caaaaatgta gttatatttg gtcaaggtca
    32041 agttgacaga tctccatgtg gaactggaac aagtgctaaa ttagctactt tacatgctaa
    32101 aggtgaatta aaagtaggag aaaaattcgt atatgaaagt atattaggaa ctttattcaa
    32161 aggtgaaata gttgaagaaa ctaaagttgc agatttcaat gctgtagtac ctaaaataac
    32221 tggttctgct tatataactg gatttaatca ttttgtaata gatgaagaag acccacttaa
    32281 acatggattt attcttaaat aagtaataaa taaattagga aattaaaata gaatagtagc
    32341 cacttgtcgg ttgctattct atagctttta ggctataaga ttcagaatat atgaaaaaat
    32401 aaaaaaatag gaggatggat tatggtagca atcttaaagg cattatatgt agtattcgca
    32461 gcaatctttg cagttgtgtt tggtaaagac gtagctaaag caaacaaaga ggggaaacta
    32521 gaagaacaaa gtactccaaa agttgctgta acaggattta taacagactt ctttgataca
    32581 ttaggaatag ggtcatttgc tccaacaata gcaatgtcaa aggctttaaa gttaaatata
    32641 ccagataaaa aaatgcctgg tacattaaac gtagcacata ctattccagt tgttacagaa
    32701 gcattcatat ttacatcaat tatcccagta gatggtgtta ctttagtatc tatggttgtg
    32761 gcagcagcag ttggttcata tataggtgca ggaataatag ctaagatgga cgagagaaaa
    32821 atacaacttg ttatgggtgt aactttagca ttaacagcaa tattaatgtt attaggtcat
    32881 ccttggatta acgtattacc aggtggagga aatgaattag gtcttactgg tgctaaatta
    32941 gtaataggtg taataggtaa ctttatacta ggagctttaa tgacagctgg tataggtcta
    33001 tatgctccag gtatggcaat ggtttatttc ttaggaatgt ctgcaaaagt tgcattccca
    33061 atagttatgg gttcttgtgc attattaatg ccagttgcaa gtatgaaatt cataaaagaa
    33121 gatgcatata ctaaaaaagc atcagttata atagctatat gtggtttaat aggagttttc
    33181 gtagctgcat atatagtaaa aactctacca atggatatat taaaagcatt agtaatagta
    33241 gttatagctt atacttctgc tacaatgata atggctgcaa ataaaaacaa aaagactgct
    33301 tagttaaaga ctacttagtg tttattaaat attacagcta ataataaaga ttataaactg
    33361 ctttaaaata ttgaattaat attttagggc agttttttat ttactaaatt aatataaagc
    33421 aattaacatg ccaattatgt aatatatata gtgatttagt agatttaatc taaaaaacgt
    33481 tgtattttta aagaataaag cataatttaa agctaaatat ttaaatttta taatcaataa
    33541 gttcaataaa tgttcatata ttaatacaga ttaataaaaa tataacctgt aataagtcta
    33601 atataactta taattaagaa aaataagttt ataatgactc aatattcatc tgaattattt
    33661 caataaattt aattcgttga agttgcttat atagagtgaa taaatttaag ttatatatg
//
LOCUS       DAEHWM010000036        33302 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.037, whole genome shotgun sequence.
ACCESSION   DAEHWM010000036 DAEHWM010000000
VERSION     DAEHWM010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 33302)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33302)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33302
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.037"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1296
                     /locus_tag="KNP36_001814"
     CDS             <1..1296
                     /locus_tag="KNP36_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0873689.1"
                     /translation="MITIDRIKKNNYIDSVEVVNYIDNNVDINIAKDISNFLESEYNI
                     TLTSAELYYLVFQLTNKTTVLNYNQMDTKSLSNYIDEHFVKLTKKIIKNVYDLYLIDL
                     SDEEFVVKFTLHVKNLISRAKNNQVLRNQIPQKLKDSYPLIYDISVYICNQIQTLENV
                     DIDEDEISYISLHVGSFFDRQKLLEDKVLCALITPNYYDLQFKIVRDLEKRFNESIEI
                     IQIFSDTHNLDFDNKVDMVITTLPINDRCPIPFVYVNPYLNRKDYDNIQSKFIQIKDR
                     KNILTVQNHLEMYFSESLFMKNIYLDSAKDYIRFMGNILYENKYVKPNYIDDVLIREK
                     MSSTAFNNNVAIPHSMKMDALKTGVCLIVNDKPVKWGEEKVQIIAMIPINEKEKEKFN
                     YIFESFIEILSEWNNVKELTKADNYSSFMNRIAYLIQNI"
     gene            complement(1419..2573)
                     /locus_tag="KNP36_001815"
     CDS             complement(1419..2573)
                     /locus_tag="KNP36_001815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HBF0873690.1"
                     /translation="MKILISIDSLKGSLSSIEAGNAIKKGILKVKEDAQVKILPLADG
                     GEGTVDALVQGMNGKKETIEVTGPIAKKVDATYGLLKNTSTAIIEIAQASGLTLVPTE
                     LRNPLYTTTYGVGEIIKEAINKGYRNFIVGIGGSATNDAGIGMLQALGFEFYDKNNKL
                     VGLGGKVLNEIRHIKIENRLKELDECKFKIACDVNNPLFGKNGAAYIYGSQKGATSEI
                     IEKLDNGLRNFSKVVKNYLSKDVANVEGAGAAGGLGFAFLAFLDSKLESGIKIILEEI
                     KLEEELKDADFVITGEGRLDNQTAMGKAPIGVAKLAKKYGVKVIGLAGATTEDAVKCN
                     EEGIDAYFSIVNRAMTIEEAMDKATASENMTATTTQIFNLITSIQQSKNM"
     gene            complement(2852..5467)
                     /gene="mngB"
                     /locus_tag="KNP36_001816"
     CDS             complement(2852..5467)
                     /gene="mngB"
                     /locus_tag="KNP36_001816"
                     /EC_number="3.2.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannosylglycerate hydrolase"
                     /protein_id="HBF0873691.1"
                     /translation="MKKNVHIVPHMHWDREWYFSTEESRILLVNNMEEIMDMLENNHN
                     YPYYVMDGQTAILEDYLAVKPECKERIKKLVQEGRLIIGPWYTQTDEMVVGGESILRN
                     LLYGIKDCDEFGEYMKIGYLPDSFGQSAQMPQILNGFDIKYSMFWRGCSERKGTNKTE
                     FNWKSDDGSSVLVQILPLGYAIGKYLPMNEDELRTRMDKYLPVLDKGATTDHIILPNG
                     HDQMPIQKNIFEVIYKLKECYPDRKFFLSRYENIFKELEKNEDIDTIKGEFLDGKYMR
                     VHRSIFSTRMDIKSANARIESKITNILEPLASIAYSLGFEYHHGLIELIWKEIMKNHA
                     HDSIGCCCSDKVHQEIMNRFFLAEEKVDQLITFYKRRIVDAMSCEMALDKLIAFNLMP
                     YDRNEIVSAQVITKMKAFEIFDKDNNKLDFEVVHKEVIDAGLIDRQIVHYGNYDSFMV
                     YTINFKDKIPAMGYKAYMIKEVEHMLEKAYEVCDMVDNDFYTIQVNENGTLKIFDKKL
                     NKTFENVLLMENGGDEGDEYDFSPLPNEKLIFNDNIVANSTIKKNRFNNEIKINYRLK
                     VPKDIQARKNNRADSFIDFDIVINVPNDKAIIDVVFNINNQARDCRVRTYIPTNIASK
                     FSVSDNQFGHIKRSVYDDAMEVWQQEDWSERPDSIYPMLTFVGLSDKEHGVAVLTNST
                     REFEIVGEKFDTIAITLFRSVGFLGKEEMARRPGRPSGIKLPTPDSQMIGDIKIDLAI
                     VTHEKSTLEANVANMAKEYLTKIQTYNKMPYNAMKLNQSEIEVDYSYSLLKETNKDLV
                     LSVVKKAEKEEALVVRFYNSKEETKSANIVFNKNIKTAKWINLNEKELESISIDNNSV
                     NVECLMNQVKTILVK"
     gene            complement(5611..7536)
                     /gene="mngA"
                     /locus_tag="KNP36_001817"
     CDS             complement(5611..7536)
                     /gene="mngA"
                     /locus_tag="KNP36_001817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS 2-O-a-mannosyl-D-glycerate transporter
                     subunit IIABC"
                     /protein_id="HBF0873692.1"
                     /translation="MEFKKITNENLVFLKQKIKTKEDAIKFLARKLYDEGKLTSYEEY
                     LEAVMYRETLSPTGFERGLAIPHGKSKSVKEAAFAAMTLETPIENWESVDPNNKVELI
                     FLIAVPESEGGNTHIQILSELVTRLSNEDYMNMLLNSKTKKELFNNLDIKEKKEQIKE
                     EIRIQNESKKIILAITACPAGIAHTYMSAEALIKAGKEIGVDVYVEKQGANGMVDPHT
                     PDIIKRADAIIYATDVAPKNTERFEHLPNIKTSVAAPLKRAKEIIYEALEVAQKQGKG
                     DYIEKSSDISYCEKSSWKKDVKSAILTGVSHIIPLIVAGGMILAFAVLASQAFGLQEL
                     YNQEGSWLWQLRKLSGGMLGTLMVPVLSAYMSYSLAEKPGLGPGFAAGLAADLIGSGF
                     LGGMLGGLLAGYIVKFLKKNIPAKGTLAGFVSFWVYPVVGSLVVGLLMLFVVGKPVAA
                     LNNGLINWLNGMTGVNAILLGAIIGAMVSFDLGGPINKAAYTFAIGAIASGNFIPYAI
                     FASVKMVSAFGVTIATVLGRDLFSESEKEIGKQTWILGLAGITEGAIPFMIEDPIRVI
                     PSLVAGSAITGSIVAFFNIGLQVPGAGIFSLALLEGSMSGFIIASIWFFAAVLGAIIS
                     AILLIITRKQKNQRKIH"
     gene            complement(7666..8391)
                     /locus_tag="KNP36_001818"
     CDS             complement(7666..8391)
                     /locus_tag="KNP36_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0873693.1"
                     /translation="MEFYERAKKYEYKFTDTEDMIIEYMRKNKEEIVKLSIQSLADKF
                     FTVPNTIVRLCKKMEYDGFSQLKNNLKEELKNEDKEPKNGFESDIKKTLELIDYEKIN
                     KVADIIQKSRSIIVYGIGQNIPLCEILVKEIRGGHDNITYYSQRHEVLHDIGKLGEQD
                     MFFALSLSGETKEVIEAAKTAVNKGCKVVALTHICENQLQQIADISLYCYSTIKQVNG
                     YNISDKVPIMMIMRAIIEQYWLR"
     gene            complement(8654..9433)
                     /locus_tag="KNP36_001819"
     CDS             complement(8654..9433)
                     /locus_tag="KNP36_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ChbG/HpnK family deacetylase"
                     /protein_id="HBF0873694.1"
                     /translation="MHKMKKLVVRADDIGYSEGVTLGIISSYKNGIVTSAGIMVNMPF
                     SRQAIEMVKNDDVCFGLHVNLVIGEPCCKEHIKIKNLLDEGGKFVSSKIRRTQLLTGK
                     EVFNYEEVYEEVCAQIETYKLYMSKLPEYIDIHGIEEDVSISAMCDAAKEYGIPSCPY
                     YLDSCISMPSKYPQNDFYKLNKSFVKLFEEKYINLDKDITLMVTHPGFIDYSLIKSSS
                     LIQERVYEHAMLCDKEVKMWLKRNNIELVDFKDIFKSNNYI"
     gene            complement(9426..10853)
                     /locus_tag="KNP36_001820"
     CDS             complement(9426..10853)
                     /locus_tag="KNP36_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0873695.1"
                     /translation="MMQQLSLLGKTMLVPIAVMPAAGILGLLFGPNMLNVPAISNISN
                     IVFSNVDYLFLLGAASAYSKSKDKTSVMVAAVVAYMIFKSNLELLNDTLNAGVFGGII
                     VGACIAWTYNKTYKVKVPAFLSFFAGEKCVITLSPVVALILSYIFSLLWIYPQAAMNQ
                     FGFWLGGAGAIGIFLFLFCNRALIPTGLHQVLNAYILFEMGEYTTSTGEVIRGEIPRF
                     MAGDPNAGFFWTGFYIIMMFSIPAISYAIYKTAQDKKKQEVKGAMTAGALTSFMATVT
                     EPIEFSFLFASPKLYIIHSFYSGLGGVVLYLLGARLGSFNGASIIDYVLSFSYGDKAW
                     LVIPVGVVFFVLYYVTFKYIIIKDNVQTPGREVEIEIGDKVSEKEKNLKLSHGNFSYM
                     AKQIIKNCGGYENIVTLNNCMTRLRLEVKDATILNDDNIKKTGAKGVIKLSNTSVQII
                     IGTDVVKVKDEMEMQLDELRKQADA"
     gene            11244..11966
                     /locus_tag="KNP36_001821"
     CDS             11244..11966
                     /locus_tag="KNP36_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0873696.1"
                     /translation="MAKNKFSEIYEVLKEEILDGKYTSNMMLPTELQLIERFSCSRNT
                     VRRAISQLNTEGYVQSIKGKGVVVLENSCSNDFFLNMHNFKGVESIVEDKKVNTATSV
                     LHFSKILIDNKLSKKTGFKVGSEVYYLHRLRYIDNIPKILDINYFLCSIVKDLDVSIA
                     QGSIYKYIEECLGTKIVSSRKIFKIEKATELELKTLPLNDYNCVGVIKNSVYTDDGKL
                     FEYTESKHTPETFVFMDVTQRY"
     gene            12163..13830
                     /locus_tag="KNP36_001822"
     CDS             12163..13830
                     /locus_tag="KNP36_001822"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HBF0873697.1"
                     /translation="MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGV
                     DLLWLTPMYVSPQRDNGYDIEDYYNIDPKYGTMSDFEKLLKEAHKRDIKIMMDMVLNH
                     TSTEHKWFKESKKSKDNPYRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYL
                     HLFEETQADLNWENEKVREECYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGP
                     KGDGRTHYADGPRIHEYLHNMNQKVFKPKNIVTVGEMSSTTPEECINYTRENREELSM
                     VFSFHHMKTDYKGGAKWTNEMFSLDKLKKAQSDFQYKMYEGKGWNALFYSNHDQPRAL
                     SRFGDDRFFRQESAKMLAITLFGLQGTTYIYQGEEIGMTNAYFTKIDEYDDAESKNAY
                     YHMIKSGIDEKEALLILQQKSRDNARTPMQWDNTIYKGFSNHKPWLKVNNDNISVENE
                     LNDSRSVFYTYQRLIKYRKQYDIFTEGTYRLLDENHKNLFVYEREYKNQNLLVISNFT
                     HDNVVYKLPETYLNKLNYTILETNYTRDIIENKMEIKPYESIMIYYK"
     gene            complement(13926..15245)
                     /locus_tag="KNP36_001823"
     CDS             complement(13926..15245)
                     /locus_tag="KNP36_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0873698.1"
                     /translation="MEKGIKLGFWSIVLLGINAIIGSGIFGLPGDAYTDIGPASILVL
                     VFCMLLAVSIALCFAEAGSWFDTDGGPYLYAKEAFGDFVGFEVGFMKWIVSMIAWATM
                     ANFFAVTLSSVWPQAAEPLTKNIIIGILVVGLGIINFMGMKQSKHLNNIMTIGKLLPI
                     VLFIAVGLFFIKGSNFTPFVIIQKGQSASSAFVAVSITLFYAFTGFESLAVAAKDMEN
                     PKKNVPKALVMVMFVVSVIYMLILGISIGVLGNGLAGSATPVADAAIKMLGPIGGYII
                     TIGTIVSVGGINIASSIFTPRSAAALVEQGLMPKSIRKTNKNGAPYIAIIVSVIGTLL
                     IAWSGSFTTLSQISVVSRFIQYIPTCLAVLILRKKYAGKDVNFRIPGGAIIPIFAVII
                     SILLLIKAGIDEPMKIVWGLGGMIIVVPIYFYMTKVYSKKYNDVEVK"
     gene            complement(15286..16032)
                     /locus_tag="KNP36_001824"
     CDS             complement(15286..16032)
                     /locus_tag="KNP36_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HBF0873699.1"
                     /translation="MKKLAKKKYPIIGISGNLLIDEGGMFPGYERAYVNNDYIQSVVM
                     CKAIPYIVPIVYDDEIIKEQVSNIDALILSGGQDVNPLIWKEEPHNKLGAISPKRDSF
                     DMKLLKHALDMKKPVLGICRGEQIINVTEGGSLYQDLSLIEGAYIKHNQQHLSNVPTH
                     TVQIKEGTKLYEILGEKEVLVNSFHHLVVNKVAPGYIVSATSKDGLIEAIEKEGSEFV
                     IGIQWHPEMMTRDYDNMKKIFMAIVKEASK"
     gene            complement(16276..18285)
                     /locus_tag="KNP36_001825"
     CDS             complement(16276..18285)
                     /locus_tag="KNP36_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0873700.1"
                     /translation="MKTIAVVTDGLSKLECFLNKNLEMIFKDKVMIKNYYLNKITEKE
                     LIKDDIILVMIDDRVLKIKKYVEDVSKIITINRSIKQKDIYKLFSLPEGIDVLVVNDN
                     KHTVLETISNLYNIGINHLNFIPYNPNEEYRNIKIAITPGEASLVPKYIEEVIDLGHR
                     YIDSSTFIQIIAKLKLDDKEITERLIKYTDEIISLYSGINTKYKELTIKADELNSIIN
                     LSNLGMAMVSDKGNIIICNNSLGDILDIQSNIIGKNIDELENENIKKIFSLSKAHDEV
                     IKFNNKYLNVNKYNIESFGRVTGYYFCIQEITYIRKLEQNLSKKLREKGQVARYTFDD
                     IKTVSTKMERTKKLGMKIAESDYTILITGESGTGKELMAQSIHNASPRHSQPFIAINC
                     AAMPENLLESELFGYEEGAFTGALKGGKKGLFEQANNGTIFLDEIGDMPIYLQSKLLR
                     VLQENQVMRVGGENVIDIDVRVIAATNKNLLEMIKGDRFRADLYYRINVLPINIPPLR
                     ERKEDIEVMLKHFMKRKRAISQDVQDIINAYEWPGNIRELKNTAMYINIMSSEDVILI
                     NDLPHNLLNITEDFSKEISILKDRTSIEKVKLVMECLKNANNLNKNIGRNGIVNSINE
                     LGYNITEGEVRGILNMLKELDLIICESGRKGSELNRRGKNILNSI"
     gene            complement(18723..20156)
                     /locus_tag="KNP36_001826"
     CDS             complement(18723..20156)
                     /locus_tag="KNP36_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBF0873701.1"
                     /translation="MALRKDFLWGGATAANQCEGAWNLDGKGPSCSDMCTGGSQKVSK
                     RITRVIEKGTFYPSHEAIDFYHRYKEDIALFAEMGFKVFRFSIAWTRIFPTGMEKEPN
                     EAGLKFYENVIDECLKYNIEPLITISHYEIPFAITEKYNGWVSRDVIDLYMNYCETIF
                     KRYKGKVKYWLTFNEINSATMPMGGYLSQGILNEGTTDFINQVDIPQLRFQGLHHQFV
                     ASAKAVKLAHEIDSNYQVGCMQIFATMYPYTCNPDDAVKTQRDSRVMNYFCGDVQVRG
                     EYPTYMNRYFGENNIEIKMEKGDLEILKEGCVDFYTFSYYMSTCVSSDSKEDNTSGNI
                     LGGVKNPYLKSSEWGWQIDPEGLRYALNEIYDRYRIPMMVVENGLGAYDKKESNGVIN
                     DDYRIEYLKAHIEQMKEAVEDGVDLFGYTPWGCIDLVSASTGEMAKRYGFIYVDKYDD
                     GSGDLSRIKKKSFDWYKQVIESNGERL"
     gene            complement(20243..22159)
                     /locus_tag="KNP36_001827"
     CDS             complement(20243..22159)
                     /locus_tag="KNP36_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0873702.1"
                     /translation="MRKYEQLSKEIIANVGGKDNISSLSHCITRLRFKLKDESIANDD
                     VLKKMDGIVTVMKSAGQYQVVIGNHVPDVYEVVCDLAGLGGDTIDNSDSDAPKGLLNK
                     FIDIISGVFQPILGVLCAAGMIKGFNAVFTALGLYGETDGAYIMLNAIGDAMFQYMPI
                     ILGYTAAKKFKLKPFIGMLIGAVLCYSGIQLDTLASTGQPLYNLFTGTIFESPVYITF
                     LGLPVIAMNYTSTVVPVILIVLLAAKLEKVFAKIIPDVVKNFFVPMAVLLVSLPLGFM
                     VIGPIATYASNIVGNGFLALFNFSPILCGALTGLLWQVLVIFGLHWGLVPIAMSNLMT
                     MGFDTILVGAFVPSFAQTAVVAAMYFKLKDKKIKELCIPAVISGICGVTEPAIYGITL
                     PRKTPFIYSCVGGGVAGAVMGIMNVKSYVMGGLGIFGIPNYINPTTGDMKGVYATIIA
                     IIVAIVVGFVLTLFFWKDDAIVEISKDDNGQGVIEKNKREVVYSPIKGEVKALEQIQD
                     AAFSTGILGKGVAITPKEGKVVAPFDGTVMTLFPTKHAIGIISDNGCELLIHIGLNTI
                     QLEGKYFKSFVNQGDKIKKGQILITFDIESISKEGYCLETPVVVTNYSDYVDILENTQ
                     KHVNNSQELITVLA"
     gene            complement(22233..23093)
                     /locus_tag="KNP36_001828"
     CDS             complement(22233..23093)
                     /locus_tag="KNP36_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0873703.1"
                     /translation="MIIEKILNNNVIITTDENHKEIVVMGRGLAYKKRTGEHISKDKI
                     DKIFKLSDPNISDKFKELIADIPIRYMELSDEIILYAKEKLGKRLNDSIYISLTDHMY
                     TAIERAREGVSVKNVLLWDIKRFYKSEFKIGLEALDYIEKKFEIRLSEDEAGFIALHI
                     VNAQMDQSIKTIYEITQIIQEISNMVKYHYRIVFDEDSVYYHRFITHLKYFAERIVSN
                     NLHENNEDDLLNVIKVKYKNAYKFIEKLDEFIHKKYNYDLTDEEKLYLTIHVERVVSK
                     SIKSDINPNN"
     gene            complement(23444..24631)
                     /locus_tag="KNP36_001829"
     CDS             complement(23444..24631)
                     /locus_tag="KNP36_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0873704.1"
                     /translation="MIESIKKRAYEIENELGKEIEEVCNFIFNNPELGEEEYISSKYL
                     VEKMKEYGFDTVYPYCNMETAFRAELGDNDGPTIAFLAEYDALPGYGENKEPAHACGH
                     NWIAASTLGACIVLSKLKENFKGKIVLIGTPAEETTGGKCDLVKAGAFDDVDVSYQMH
                     IEAFNNINCKALAIDSLEFSFEGVSAHAASHPHMGVNALDAVQLTFAGINALRQHVKS
                     DVRIHGIVSNGGEAPNIVPEKAACKFFVRAAERSYLDEVTKKVINCAKGAELMTGAKL
                     SYRYFENSFDNIINNKVLQKITKNNLIEAGITDILEGKDGPVGSTDIGNVSQVCPTMY
                     TEIALDISPMVYVHEKEFLNYANSEEAYDKLHKAVKAMVGCALEIYLEDGLLDEIKKN
                     HLN"
     gene            complement(24645..26036)
                     /locus_tag="KNP36_001830"
     CDS             complement(24645..26036)
                     /locus_tag="KNP36_001830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HBF0873705.1"
                     /translation="MSSLKKKKFTMPQTLTIIFLLIVLMAILTWIVPSGNFERVDIDG
                     RSVVVAGTYEKAPSNPQGITDVFTAPINGFIDAAEVVGFVLIVGGAFGIVNKTGAIEA
                     VIAHTVNKMKKFQFLIIPISMILFGLGGTTFGMSEETLPFYMIFIPLMTSMGYDSLTA
                     VATVFIGATAGFGAATTNPFSVGIAQALSQIVPGSGIEFRVVMFIIYMAISIGFVMMY
                     ANKVKKDPKKSLVHDISLNQELMVNSDTNIKEFTKREAMVIAIFTIGMAIMIYGVLRL
                     EWYITEIAMIFTAIGIISGIASGLKQDEIVNSFISGAGDLITAGLCIAFARGIVIIAE
                     NGFIIDTILNSAANLLNGLPKTIFINLTFLIEGLIAFLIPSASGLASLTIPVLAPLGD
                     LVDVSRQMIVTAYQFGIGVTNLITPTSGVLMGALAVANIPWSKWVRFVIPLMVVLTIL
                     VIAFLTIGLYLGF"
     gene            complement(26631..28331)
                     /locus_tag="KNP36_001831"
     CDS             complement(26631..28331)
                     /locus_tag="KNP36_001831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0873706.1"
                     /translation="MHYIAWHFNKNGGNNTMKDKLQVLSGAMMIPVILLVVAGVFIGL
                     GSAFANMENVSALGLSGLIKEGSFINVFFKVINDLGFMVMRYLPIFFVTGIAFGLSKK
                     EKGWGALGGIVLFIGMHTVISTLLAANGINSDTVTAEAFMASGLGEAEAYSRSSLYGS
                     FLGIFSYDCSIFGAIIAGFVASAVHNKFVDIELPSALSFFSGPRFSMIMMFIASIVLG
                     TAMYFIWPPVGLALSKLGNWIGSSGLLGTFTFGAMDKALLPFGIHHLIAFPIEYTRVG
                     GTMEVGGAIYEGVNNIRLAQMGDPDTLSYITRNFTTGRLLIHFAILPAAALAMYKLAD
                     NANKKKAISILIPAIVTAMLVGVTEPIEYTFLFVAPLLYFVAYVPLAGLTYVFTEMFN
                     VSIMGESFRNMFPNLLQPQKVDALPLLFLIPIFFIVTYIIFTWAIKKFDIKTPGRSSE
                     EVKLYSKKEYRERQSVDAGKTAYNNAVEEEVDDKDTKLVHSIIEGLGGSNNIKNVTNC
                     ATRLRVELNSIDGFYEDGFWVNELGASGVVKKKNSVQVIFGPRVITIASKLKAVLGVD
                     "
     gene            complement(28303..29706)
                     /locus_tag="KNP36_001832"
     CDS             complement(28303..29706)
                     /locus_tag="KNP36_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0873707.1"
                     /translation="MIVNKELIIDYLKSNQENIINDIRSLVEIPSIRDESTTDINQPF
                     GIEIRNAFDKLIQIAKDKDFVVKDFDGYAIHIEYGEGEEVVGVLNHIDVVPIYNKELW
                     KSKPFKVCQKDNYLYGRGVNDNKGPLIGILYALLFLRELNEKPKRKIRLIVGGAEETT
                     WECMEHYFSVNEQPKFAFSPDGNFPIVNGEKGILYFNLRKKIDKDKFRNHNLVDIKSN
                     KEDGFVCDKIEAVFKTNDKKDLVESLAYYTEIEELDEGKVLVRYTGERALSRNPHRSY
                     NCAFSLAKDLEKIKKLNDKGVIIRDILNSYFTDDNHGKKLGMYKEDVDMGVSTICIMS
                     IFLEKNELNMKIDFRYPKGISWEFITNRINEIGKKENLIVDIYKDLKLLYVKPDSELI
                     NKLSNAYKQGFGKEAELFTKGAASYARVLKNGVAFGPTIEGDNPNSHQANENISIDTL
                     YKAIEVYIYALYSLAFQ"
     gene            complement(29970..30461)
                     /locus_tag="KNP36_001833"
     CDS             complement(29970..30461)
                     /locus_tag="KNP36_001833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0873708.1"
                     /translation="MFNIFKKKENKIEKIYSPFKGNLVNLEDVPDAVFAQKMMGDGVA
                     IIPSEGKLYSPVDGEIVNVFDTKHAIMIKSNDNTNILIHVGLETMSLEGKPFDVKVKA
                     GDKVKAKDLIMEVDLDFITSNDLNIITPVVIMDDADSVKRTVKDRIEPGNVDINSIIM
                     EVE"
     gene            complement(30487..31299)
                     /locus_tag="KNP36_001834"
     CDS             complement(30487..31299)
                     /locus_tag="KNP36_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBF0873709.1"
                     /translation="MRYKLICTDMDGTLMGKGFEVSEENIKALKEAMEKGIKVALVTG
                     RPYNAMKYFTSVLGDDIYIISTNGTYFKLLGYEYKKVLSKEALKKIYTIGEKYNLNKH
                     FKGCKIVISNNEIGEEHPYRLINSKNKEEDRIEIIENASCETLLEKADNEILKCILFS
                     ENVDSLREAKEEFKKQEDLEVVSSGKINFEVMSKGTSKGIAVKKFCDILGIDSKEVIC
                     IGDNENDISMIKFAGLGIAMGNATDEVKSMADFVTDTNVNDGVAKALRKILS"
     gene            complement(31312..32271)
                     /locus_tag="KNP36_001835"
                     /pseudo
     CDS             complement(31312..32271)
                     /locus_tag="KNP36_001835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422425.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
     gene            complement(32389..>33302)
                     /locus_tag="KNP36_001836"
     CDS             complement(32389..>33302)
                     /locus_tag="KNP36_001836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0873710.1"
                     /translation="LKEPDKFSLQNALKDLDNAYKKFFKEKAGFPKFKSKKINRFSYK
                     TNFTNGNIMYCGQYIKLPKLGMVKIRDKQVPQGRILNATISKEPSGRYYVSLCCTDVD
                     IEAFENTNNHIGLDLGIKEFCISSCGEFIENPKYLKKSLNKLAKLQRELSRKTIGSLN
                     RNKARLKVARLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNMIKNRKLSRSIS
                     DVSWSEFIRQLEYKANWHGRQIVKVGKFFASSQICNKCGYKNEEVKDLNIREWICPSC
                     NETHDRDINASINILKEGLRLITIQNK"
BASE COUNT        10647 a         6073 c         3657 g        12925 t
ORIGIN      
        1 atgataacta tagacagaat aaaaaagaat aattacatag actctgttga agtagtaaac
       61 tacatagaca ataacgtaga tataaatatt gcaaaagaca tatcaaattt tttagaatct
      121 gaatacaata taactttaac tagtgcggaa ttatactatt tagtatttca gttaacaaac
      181 aaaactacag tcttaaacta caatcaaatg gatactaaat cattgtcaaa ttatatagat
      241 gaacactttg ttaaattaac taaaaaaata attaaaaatg tatatgactt atatcttata
      301 gatttatctg atgaggaatt tgttgtaaaa tttactcttc atgtaaaaaa tttaatcagt
      361 agagccaaaa ataatcaagt tttaagaaat caaatacctc aaaagttaaa agattcctac
      421 cctttgatat atgatatatc tgtttatatt tgcaatcaga ttcaaacttt agaaaatgta
      481 gatatagacg aagatgaaat atcttatata tctcttcatg taggttcatt ctttgataga
      541 caaaaattat tagaagataa agttctatgt gcattaatta ctccaaatta ctatgattta
      601 caattcaaaa tagtaagaga ccttgagaag agatttaatg aatccataga aattattcag
      661 attttttcag atactcataa tcttgatttt gacaataagg tagacatggt tattactact
      721 ttaccaatta acgatagatg ccctatacct tttgtttatg taaatcctta cctaaataga
      781 aaggattatg ataatattca aagtaaattt attcagatta aagatagaaa aaatatactt
      841 actgtacaaa atcatttaga aatgtacttt agtgaatctt tgtttatgaa aaatatatat
      901 ttagatagtg ctaaagatta tataagattt atgggaaata ttctgtacga aaataaatat
      961 gtcaaaccca attatataga tgatgttctt ataagagaaa aaatgtcttc aactgcattt
     1021 aataacaatg tagcaattcc tcatagcatg aaaatggatg ctttaaaaac cggagtatgt
     1081 ttaattgtta acgataaacc agttaaatgg ggtgaggaaa aagttcaaat tatagctatg
     1141 atacctataa atgaaaaaga aaaagaaaaa ttcaattaca tatttgaaag ctttattgaa
     1201 atattatctg aatggaataa tgttaaagaa cttactaagg cagataacta tagtagtttt
     1261 atgaatagaa tagcttatct tattcaaaat atctaaatcc attaatttat ttccaatata
     1321 tgtttcttaa gttattaaca taaaatagat aagctgtcac actaaaaagt ctaaattaat
     1381 atgtgacagc tttttaccta atataccttg ttttaatact acatattttt tgactgttgt
     1441 atactagtta taagattgaa tatttgtgtt gttgtagctg tcatattctc actagcagtt
     1501 gctttatcca ttgcttcttc tattgtcata gctctattta ctatagaaaa ataagcatct
     1561 ataccctctt cattacattt aactgcatct tctgttgtgg ctccagccaa acctattact
     1621 tttaccccat atttttttgc cagttttgca actcctattg gagccttgcc catagcagtt
     1681 tgattgtcca atctaccttc accagttatg acaaaatctg catcttttaa ctcttcctct
     1741 aatttaattt cttctaatat tatttttatt ccagattcta attttgaatc taaaaatgct
     1801 aaaaaagcaa aacctaatcc tcctgctgct cctgctcctt ctacattagc tacatcttta
     1861 cttaagtaat ttttaactac tttggaaaaa tttctaagcc cattatctaa cttctcaatt
     1921 atttctgatg ttgcaccttt ttgagacccg tatatgtatg cagctccatt tttcccaaac
     1981 agcggattat ttacatcaca ggctatttta aacttacatt catctaattc ctttaatcta
     2041 ttttctattt ttatatgtct tatttcattt aaaacttttc cacctaatcc tactaacttg
     2101 ttatttttat cataaaactc aaaccctaag gcttgaagca tacctatccc agcatcatta
     2161 gtagcacttc cacctatccc aactataaaa tttctatagc ctttatttat tgcttccttt
     2221 attatttccc caacaccata agttgtagtg tataaaggat ttctaagttc agtcggaacc
     2281 aatgttaatc ctgatgcttg agctatttct attattgctg tacttgtatt ttttaataat
     2341 ccatatgttg catccacttt tttagctatt ggtccagtaa cttctatagt ctctttttta
     2401 ccattcatcc cttgaactaa agcatctact gtcccttcac caccatcagc aagtggcaat
     2461 atctttactt gcgcatcttc tttaaccttc aatatcccct tttttattgc atttcctgcc
     2521 tctattgaag ataagcttcc tttcaaagaa tctatagaaa ttaatatttt catacttatc
     2581 tactcctttt tattactcct tattttaaac atataatttt ataagcttaa tttatctttt
     2641 attttatact ctacatctct ctttgtatac aacttatacc attaatattc ttttatctta
     2701 taaaaaggga gtgtctcaaa ataaatttct tagttcatga gacactcttt tgtataaaat
     2761 caaatatatg tttattattt caacaatgat aaggaggatt atctctattt taagataatt
     2821 cctttttagc actatctaat catttttagc actatttaac cagtatagtt ttaacttggt
     2881 tcattaagca ctctacattt acagagttat tatctattga tatagattct aattcttttt
     2941 catttaggtt aatccattta gctgttttaa tatttttgtt aaatactatg ttagctgatt
     3001 ttgtttcttc tttagaatta taaaatctaa ctactaatgc ctcttctttt tcagcctttt
     3061 ttacaacact taacacaagg tccttattag tttccttaag taaactatat gaataatcta
     3121 cttctatttc tgattgattc aatttcatag cattatatgg cattttatta taagtttgta
     3181 tttttgttaa atactcttta gccatatttg caacatttgc ttctagtgta gatttttcat
     3241 gagtaactat tgctaagtct atttttatat ctcctatcat ttgagaatct ggagtaggca
     3301 actttattcc tgatggacga cctgggcgtc ttgccatttc ttctttacct aggaatccta
     3361 cacttctaaa taatgttata gctattgtgt caaatttttc ccctactatt tcaaactctc
     3421 ttgtactgtt tgtaagaaca gctactccat gctctttgtc agacaatcca acgaatgtta
     3481 gcattggata tatagaatct ggtctttcac tccagtcttc ctgttgccaa acttccatag
     3541 catcatcata cacacttctc tttatatgtc caaactgatt atcagacaca gaaaactttg
     3601 aagctatatt tgttggtata taagttctaa ccctacaatc tcttgcttgg ttatttatgt
     3661 tgaatactac atctattata gctttatcat ttggaacatt tataactata tcaaagtcaa
     3721 taaatgaatc tgctctatta ttttttctag cttgtatatc ttttggtact tttaatctat
     3781 aatttatctt tatctcatta ttaaatctat ttttctttat agtggaattt gctactatat
     3841 tatcgttaaa tattaatttc tcatttggaa gtggtgaaaa atcatactca tctccttcat
     3901 ctcctccatt ttccatcaat aatacatttt caaaagtttt atttaatttt ttatcaaata
     3961 tctttaatgt cccgttttca ttaacttgaa tagtataaaa gtcattatct accatgtcac
     4021 atacttcata agctttttct aacatatgtt caacttcttt tatcatatac gccttatacc
     4081 ccattgcagg tattttatct ttaaagttta ttgtatatac cataaatgaa tcatagtttc
     4141 cataatgaac aatttgacgg tctattaatc ctgcatctat tacttcttta tgtaccactt
     4201 caaaatccaa cttattatta tctttatcaa atatttcaaa tgctttcatt ttagttataa
     4261 cttgggcgct cactatttca ttcctatcgt aaggcattaa gttaaatgct attaacttat
     4321 ctaaagccat ttcacaactc attgcatcaa ctattcttct tttgtaaaat gttattaatt
     4381 ggtctacttt ttcctcagct aagaaaaatc tattcattat ttcctggtga actttatctg
     4441 aacaacaaca tccaatgctg tcatgagcat gatttttcat tatttctttc caaattaact
     4501 ctattaatcc atgatgatat tcaaatccta gagaatatgc aatagaagct agtggctcca
     4561 atatgttagt tatctttgat tctattctag catttgctga ttttatatcc attcttgttg
     4621 agaatatact tctatgaacc ctcatatatt tcccatctaa aaattcccct tttattgtat
     4681 ctatatcctc atttttttct agctctttaa atatgttttc atatctactt aagaaaaatt
     4741 ttctgtctgg ataacattct tttaatttat atataacttc aaatatattc ttttgaattg
     4801 gcatttggtc atgtccattt ggaagtatta tatggtcagt agttgcaccc ttatcaagaa
     4861 ccggtaaata tttatccatt cttgttctta gctcatcttc attcattggt agatattttc
     4921 ctattgcata acctaatgga agtatttgaa ccaaaacaga agacccatca tcactcttcc
     4981 aattaaactc tgttttatta gttccttttc tttcagaaca tcctctccaa aacattgaat
     5041 attttatatc aaacccattt agtatttgtg gcatttgagc actttgacca aatgaatctg
     5101 gtaaatatcc tattttcata tattctccaa attcatcaca atcttttatt ccatatagta
     5161 aatttctaag tatggattct ccaccaacta ccatttcatc agtttgagta taccaaggac
     5221 ctattattag ccttccttct tgaactaatt tttttattct ctccttacat tcaggcttaa
     5281 ctgctaaata atcttctaat atagcagttt gaccatccat cacataatat ggatagttat
     5341 gattattttc taacatatcc attatttctt ccatattatt tacaagtaat attctagatt
     5401 cctcagttga gaagtaccat tctctatccc aatgcatatg aggaactatg tgtacatttt
     5461 ttttcattgc ttatcctcca aaacttatct gataatattt tctgtctaat taaaaatcca
     5521 ataaaaatac tactgagttt acaaaatttt ttaatattta ttttatcact ataattaaac
     5581 ctttgattta aatatctaat aacgtatctt ttaatgtatc tttctttgat ttttttgttt
     5641 cctagttatt attaataata ttgctgatat tatagctcca agtactgccg caaagaacca
     5701 tattgatgct ataataaatc ctgacatact tccctctaaa agcgccaatg agaatatccc
     5761 cgctccaggc acttgaagac ctatattgaa gaatgctact atagacccag ttatggctga
     5821 accagctacc aatgatggta taacacggat tgggtcctct atcataaatg gtattgcacc
     5881 ttcagttatt ccagccaatc ctaatatcca agtttgcttt cctatttcct tttctgattc
     5941 tgaaaataaa tctctgccta aaacagtagc tattgtaact ccaaaagctg aaaccatctt
     6001 aactgatgca aatattgcat aaggtataaa atttccactt gctattgctc ctattgcaaa
     6061 tgtataggct gctttattta ttggtccacc taagtcaaat gaaaccatag ctcctattat
     6121 tgcacctagt agtattgcat ttactccagt catcccattt aaccaattta taagaccatt
     6181 gttaagtgct gctacaggct ttcctactac aaataacatc aataaaccta ctaccaaaga
     6241 accaactact ggatataccc aaaaacttac gaatccagct aatgtgcctt tggctggtat
     6301 attcttcttt aaaaatttta ctatataacc agcaagtaaa cctcctaaca tacctccaag
     6361 aaatccacta cctattaaat cagctgctag acctgctgca aatcctggtc caagacctgg
     6421 tttttcagct agtgagtaag acatatatgc tgataatact ggaaccatca atgtacctaa
     6481 catacctcca gaaagctttc ttaattgcca taaccaagaa ccttcttgat tgtatagttc
     6541 ttgtagacca aatgcttgag atgctaatac tgcaaatgca agtatcatac ctcctgccac
     6601 aataagtggt attatatgag atactcctgt aagtattgct gattttacat cttttttcca
     6661 tgatgatttt tcacaatatg atatatcaga tgatttttct atataatcac ctttaccttg
     6721 tttttgtgct acttctaaag cttcgtatat tatttctttt gctcttttta gtggagctgc
     6781 tactgacgtt tttatgtttg gcaaatgttc aaatctttct gtatttttag gtgctacatc
     6841 tgttgcatat attattgcat ctgccctttt tattatatct ggcgtatgag ggtccaccat
     6901 accattagct ccttgctttt ctacatacac atccacacct atttctttac cagctttaat
     6961 taatgcttct gctgacatat atgtatgtgc tataccggca gggcatgctg ttattgctaa
     7021 tataattttt tttgattcat tttgaatcct aatctcttct tttatttgtt ctttcttttc
     7081 ttttatatct aagttattaa ataactcttt cttagttttt gaatttaaca acatattcat
     7141 ataatcttca tttgacagtc tagtaactaa ctcagaaagt atttgtatgt gtgtatttcc
     7201 accttcactt tctggtactg ctattaaaaa tattagctct actttattat ttgggtctac
     7261 gctttcccaa ttttctattg gtgtctctaa ggtcatagct gcaaatgcag cttctttaac
     7321 tgacttagat tttccatgag gaattgcaag ccctctttca aaacctgttg gagataaagt
     7381 ttctctgtac attacagctt ctaaatattc ctcataagat gttaacttgc cttcatcata
     7441 tagctttctt gctaagaact ttattgcgtc ttcctttgtt tttatttttt gttttaaaaa
     7501 aacaaggttt tcatttgtga ttttcttaaa ttccaaaatt acgccctcct taaatcattt
     7561 aatgctatga atatagcata aaataaatta tgaaaatgtt tttttgaaat tatacacaca
     7621 atttcttctt aaaaaataaa gatttgtgta tttatacaca aatctctatc ttaaccaata
     7681 ttgctctatt attgctctca taatcatcat aattggaacc ttatctgata tattgtaccc
     7741 atttacttgt ttaattgttg aatagcaata taaacttata tctgcaattt gttgcaattg
     7801 attttcacat atatgtgtta aagctactac cttacaaccc ttattaactg ctgtctttgc
     7861 tgcttctata acttctttcg tttctccact taaactaagt gcaaaaaaca tatcttgttc
     7921 acctaatttt cctatatcat gaagtacttc atgtctttga ctatagtaag ttatattatc
     7981 atgcccacct ctaatttctt ttactaatat ctcacataaa ggaatgtttt gacctattcc
     8041 ataaactata atactcctag atttttgaat tatatctgct actttattta ttttttcata
     8101 atctattagc tctaatgtct tttttatatc tgattcaaaa ccattttttg gctctttatc
     8161 ctcatttttt aactcttctt ttaaattatt ttttagttga gagaaaccat catactccat
     8221 ttttttacat agcctaacta tggtatttgg gacagtaaaa aatttatctg ctaaagattg
     8281 tattgataat tttactattt cttctttgtt ttttctcata tattcaatta tcatgtcttc
     8341 tgtatctgta aatttatact catatttttt tgctctttca taaaattcca tagtttctcc
     8401 tccatctatt ttattattca taagtaaaat tcaaaaatat tagctaaaat tttcgttaat
     8461 ataattataa tttaatattt ttaatttatt aatgcatact actcttttta ttatacataa
     8521 aaaatgtgta cttcctatat tgatagagat gattcaagtt tttattttga tacatctcta
     8581 tcaatatttt tttagaaaat acacattttt ttcaaatact tatttttaat taaaacttta
     8641 ggtaatctat tctttatata taattattag acttgaaaat atctttaaaa tcaaccaatt
     8701 caatattatt tctttttaac cacattttaa cttccttatc acatagcatt gcatgttcat
     8761 atactctctc ttgaataaga gaagatgatt ttataagact ataatctata aatcctggat
     8821 gagtaaccat caatgttata tctttatcta aatttatata tttttcttca aataatttaa
     8881 caaaagattt atttaacttg taaaaatcat tctgaggata tttacttggc atgctaatac
     8941 atgaatccaa ataataggga caacttggta taccgtattc ttttgcagca tcacacattg
     9001 ctgatattga tacatcttct tctataccat gtatatcaat atactcaggc aatttactca
     9061 tatacaactt gtaagtttca atttgagcac aaacttcttc atatacttct tcataattaa
     9121 aaacctcttt acctgtcagt agttgcgttc ttcttatttt gctagaaaca aattttccac
     9181 cttcatctaa caaattcttt atcttaatat gttctttgca acaaggttct cctattacta
     9241 aattaacatg taaaccaaaa catacatcat cattttttac catttctata gcttgtcttg
     9301 aaaaaggcat attcaccatg attccagcac ttgtaacaat accgttctta taagaagata
     9361 ttatccctag tgtaacacct tctgaatatc ctatatcatc tgccctaact actaatttct
     9421 tcattttatg catctgcctg ctttctcaac tcatcaagtt gcatttccat ctcatccttt
     9481 actttaacaa catccgttcc tatgatgatt tgaactgatg tattactcaa tttaattacc
     9541 cctttggctc ctgttttttt aatattatca tcattcaaaa tagtggcatc cttcacttct
     9601 aaacgtaatc tcgtcataca attattaaga gtcactatat tttcataacc accacaattt
     9661 ttaattatct gtttagccat atatgaaaaa ttaccatgag aaagttttaa attcttttct
     9721 ttttcactaa ctttatcacc tatctctatc tcaacttcac gtcctggtgt ttgcacatta
     9781 tcttttatta ttatatattt aaatgttaca taatataata caaagaatac aactcctaca
     9841 ggtataacta accacgcttt atctccataa ctaaaactta agacatagtc aattatactt
     9901 gctccattaa atgaacccaa gcgagcaccc aataaatata gtacaactcc acctagacca
     9961 gaataaaaag aatgaattat atataacttt ggagatgcaa ataaaaacga aaattctatt
    10021 ggttcagtta ctgttgccat aaaagaagtc aatgctccag cggtcattgc accttttact
    10081 tcttgcttct ttttatcttg tgctgtttta tatatagcat aagaaatagc aggtattgaa
    10141 aacatcataa ttatgtaaaa tcctgtccag aagaatcctg catttgggtc tcctgccata
    10201 aatctaggaa tttctcctct tataacttct cctgttgatg ttgtatattc acccatttca
    10261 aataatatgt aagcatttaa aacttgatgt aacccagttg gtattagtgc acggttacag
    10321 aataaaaaca agaatattcc tattgcacca gctcctccca accaaaaacc aaattgattc
    10381 attgcagctt gtggatatat ccataataaa ctaaatatat atgataaaat taaagcaacc
    10441 actggtgata gtgtaattac acatttttct cctgcaaaga agcttaaaaa tgctggaact
    10501 ttaactttat atgttttatt gtaagtccat gctatacaag ctccaacaat tatcccacca
    10561 aatacacctg catttaatgt atcattcaat aactctaaat ttgacttaaa tatcatatat
    10621 gcaactacgg ctgcaaccat tacacttgtc ttgtctttag actttgagta ggcactagct
    10681 gctcctaata aaaataagta gtccacattt gaaaatacta tattagatat attagatata
    10741 gctggcacat tgagcatatt tggaccaaat aataatccta atatacctgc tgctggcatt
    10801 acagctattg gcaccagcat agtctttcct aaaagtgaca gttgttgcat cattttgttt
    10861 aagaatctct tcatatccaa tcccctttct atttcggttt aattttttgt gaaaacgatt
    10921 tattcacatt ttatatttta aatattatat ttgtttaaac aaattgtcaa tattttttat
    10981 tcattttatt tttatcattt agtttaacat ataaatcctt ttaagtgtat tgctatatct
    11041 agtctatttt tttaattcat tttttttatt ttaaaaatat gtttaaccat gtatttgaaa
    11101 caacccacaa aataattcta ttttgtcctt tttatggttg atatgattct attttcacta
    11161 tacatgtcta aacacatttg atataatttg ttcatatcag ttcaataata ttactaaaga
    11221 cctttaagga gggatagggg tatatggcta aaaataaatt ttcagagata tatgaagtat
    11281 tgaaagagga aatacttgat ggtaaatata caagtaatat gatgctgcct actgaacttc
    11341 aacttattga aaggttttca tgtagcagaa acactgtacg tagagcaatt tctcaattaa
    11401 acacagaagg atatgttcaa agtataaaag gcaagggtgt tgtagtgtta gaaaatagtt
    11461 gttctaatga tttttttcta aatatgcaca atttcaaagg tgtagaatcg attgtagaag
    11521 ataaaaaggt taatactgct actagtgttc tccacttcag caaaatctta attgataata
    11581 agttatctaa aaagacaggt tttaaagttg gtagtgaagt atattacctt cacagactaa
    11641 gatatattga taacatacct aaaattctcg acattaacta ttttctatgt agtatagtta
    11701 aagaccttga tgtttctata gcacaaggct ctatttataa atatatagaa gagtgtctag
    11761 gtacaaaaat tgtttcatca agaaagatat ttaaaattga aaaagctaca gaacttgagt
    11821 taaaaacgct acctctaaat gattataatt gtgttggtgt tattaaaaat agtgtatata
    11881 ctgatgatgg aaagcttttt gaatatactg aatcaaagca tacacctgaa acatttgtat
    11941 tcatggatgt tactcaaaga tattaaaaaa attatgttta attaaacata atttttttac
    12001 gtttagacac tttatcccat actaacctca ctattctata tacaattata tgtttataca
    12061 aataattatt tattgtatat tttagcttta atattagttt aacgcttgac aatttgttta
    12121 aacatattat aattaactta taaattacag gaggtatcaa gtatgaaaaa ttggtggaaa
    12181 aaagcaactg tctatcaaat atatccaaaa agtttcaaag atagcaacaa tgatggtata
    12241 ggtgatataa atggtattat agaaaaatta gattatctgt attctttagg tgttgattta
    12301 ttatggttga ctcctatgta cgtttctcct caaagagata atggatatga tatagaagat
    12361 tattataata tagacccaaa atatgggaca atgagtgact ttgaaaaact cttaaaagaa
    12421 gctcataaaa gagacataaa aataatgatg gatatggtcc taaaccatac atctactgaa
    12481 cataaatggt ttaaagaatc taaaaaaagc aaagacaatc catatcgtga ttattatttc
    12541 tggaaagatg ctaaacctga tggttctgtt cctaataact ggatatccag atttagtgga
    12601 actgcttgga aatatgatga aaccactaac caatattatt tacatttatt tgaagaaact
    12661 caagctgatt taaattggga aaatgaaaag gttcgtgaag aatgttacaa aatactagaa
    12721 ttttgggctg ataaaggtat tgatggtttt cgtttagatg tagtcaacct actctccaaa
    12781 acacctggat tacctgatga ccctataaca ggaccaaaag gagatggaag aactcactac
    12841 gctgatggtc ctcgtataca cgaatattta cataatatga atcaaaaagt tttcaaacct
    12901 aaaaatatag ttactgtagg tgaaatgtca tctactacac ctgaagagtg tatcaactat
    12961 actagagaaa atcgagaaga actatctatg gtttttagct tccatcatat gaaaacagat
    13021 tataaaggag gcgcaaaatg gactaatgaa atgttctctc tggataaatt aaaaaaagca
    13081 caatctgact ttcaatataa aatgtatgaa ggaaaaggat ggaatgctct attttactct
    13141 aatcacgacc aacctagagc tttatctaga tttggagatg atagattttt tcgtcaagaa
    13201 agtgctaaga tgttagccat aacattattt ggtctacagg gtactacata catatatcaa
    13261 ggtgaagaaa taggtatgac aaatgcctac tttactaaaa tagatgaata tgatgatgct
    13321 gaaagtaaga atgcatacta tcatatgatt aaatctggta ttgatgaaaa ggaggcattg
    13381 cttatacttc aacaaaaatc cagagataat gcccgtactc ctatgcaatg ggataatact
    13441 atttataagg ggttttctaa tcataaaccg tggttaaaag ttaataatga caatattagt
    13501 gtagaaaatg agcttaatga ttctcgttca gtattttata cttatcaaag attaatcaaa
    13561 tatcgtaaac aatatgatat ttttacagaa ggtacttata gattgttaga tgaaaatcat
    13621 aaaaatctat ttgtttatga aagagagtat aaaaaccaaa atcttcttgt tataagtaat
    13681 tttactcatg ataatgtagt atataaatta cctgaaactt atttgaataa attaaactac
    13741 acaatacttg aaaccaatta cactagagat ataattgaaa ataaaatgga aataaaacct
    13801 tacgaaagta taatgatata ttataaataa agttatttat gtaaaaatcg gtataacacc
    13861 ctggtgttat accaatttta ctaaattcaa agtaatattt atagaatatc tatagattac
    13921 aataattatt tgacttctac atcattatat ttctttgaat atactttagt catatagaaa
    13981 tatataggaa ctacaattat catcccacct aatccccaaa ctatcttcat aggttcatca
    14041 atacctgctt ttatcagtaa taatatactt ataataactg caaatattgg tataattgct
    14101 cctccaggta ttctaaaatt tacatcttta ccagcatact tctttctcaa tattagtaca
    14161 gctaaacatg taggaatata ttgaataaat ctagatacaa cacttatttg agataatgtt
    14221 gtgaatgaac ccgaccatgc tattagtaaa gttcctatga cagatactat aattgctata
    14281 taaggagctc catttttatt agtttttctt atagacttag gcattaatcc ttgttcaacc
    14341 aaagcagcag cagaccttgg tgtaaatatg gatgatgcaa tatttatacc tccaacagat
    14401 actatagttc ctattgtaat tatataccca cctataggac ctaacatctt aatggcagca
    14461 tctgcaacag gagtagctga ccctgctaag ccattaccca acacccctat acttattccc
    14521 agtataagca tatatattac tgatactaca aacattacca ttaccaatgc tttaggtaca
    14581 tttttcttag ggttctccat atcttttgct gcaacagcta aagattcaaa tcctgtaaaa
    14641 gcataaaata aagttataga tactgctaca aaagctgatg acgcactttg acctttttgt
    14701 attattacaa atggggtaaa attagaaccc tttataaaga ataatcctac agctataaat
    14761 aaaactattg gtaataattt tcctatagtc atgatattat ttaagtgctt agattgtttc
    14821 atccccataa aatttataat cccaagtcct acaactaata taccaattat tatattttta
    14881 gtaagtggtt ctgctgcttg tggccataca gatgatagtg ttacagcaaa gaaatttgcc
    14941 atagtagccc aagcaatcat actaactatc cacttcataa atccaacttc aaatccaaca
    15001 aaatctccaa atgcctcttt tgcataaaga tagggccctc catcagtatc aaaccaacta
    15061 cctgcttcag caaaacataa agcaatagaa acagctaaaa gcatacaaaa aactaatact
    15121 aatatacttg ctggacctat atctgtataa gcatcaccag gtaacccgaa tatacctgac
    15181 cctattattg cattgattcc taatagtaca atactccaaa aacctaactt aatgcctttt
    15241 tccattgtta ttccccccaa agccaactta atatatttgt attttttatt tagatgcttc
    15301 tttaactatt gccataaata tttttttcat attatcataa tccctagtca tcatttctgg
    15361 atgccattgt atccctatta caaactcact tccttccttt tctatagctt caattaaacc
    15421 gtctttagat gtagctgaaa caatatatcc cggtgctact ttgttgacaa ctaagtgatg
    15481 aaaactatta actaaaactt ctttttctcc taatatttca tataattttg tcccctcctt
    15541 tatctgtact gtatgtgtag gtacattaga tagatgttgc tgattgtgtt taatataagc
    15601 accttcaatt aaagataaat cttgatacaa actacctcct tcagttacat ttataatttg
    15661 ttctcctcta catataccta aaactggttt tttcatatct aaagcatgtt ttaataattt
    15721 catatcaaaa ctatctctct ttggtgatat tgcccccaac ttattatgag gttcttcttt
    15781 ccatatgagt ggatttacat cttgtccccc agatagtata agcgcatcta tattagatac
    15841 ctgctccttt ataatctcat catcatatac aatcggtaca atatatggta tagctttaca
    15901 cataactact gattgtatat aatcattatt tacataagcc ctttcatagc caggaaacat
    15961 tcctccttca tcaattagta aattacctga tattcctatt attggatatt tctttttagc
    16021 caatttcttc accccttaac ttatttgtga acaataaaaa atgctacttc tcttaaagag
    16081 caagtagcat accaagattt tatttatttg aacattataa tttattttag aaatactttt
    16141 tttgaatacg agtaatataa ataactttat ttacttatat tttattttaa tcctgtttag
    16201 tttgactttt ttaaattgtt ttaagtacaa ctaataggta aaataggcat ttagattttc
    16261 ctttttatca acctattaaa tactgtttaa tatatttttt ccccttctat ttaattcact
    16321 tccctttcta ccagattcac atattatcaa atccagctct tttaacatat taagtattcc
    16381 ccttacctca ccttctgtta tattgtagcc taattcattt attgaattaa caataccatt
    16441 tctacctata tttttattaa gattattggc attttttaaa cactccatta ctaactttac
    16501 tttctctata gatgttctat cctttaatat acttatttct ttactaaaat cttcagttat
    16561 atttaataag ttatgaggta aatcatttat taaaataaca tcctcagaac tcataatgtt
    16621 aatatacata gcagtatttt ttaattctct tatattacct ggccattcat atgcattaat
    16681 aatgtcttga acatcttgac taattgctct cttccttttc ataaaatgct ttaacataac
    16741 ttctatatct tcttttcgct ctcttaaagg tggtatattt atgggcaata catttatcct
    16801 atagtataaa tctgctctaa atctatctcc ttttatcatt tctaataaat ttttatttgt
    16861 agccgcaatt actctaacat ctatatctat tacattttct cctccaaccc tcattacttg
    16921 attctcttgt aatactctaa gtaatttgct ttgtaagtat ataggcatgt ctcctatttc
    16981 atccaaaaat atagttccat tgttagcctg ttcaaataat ccttttttac ctccttttaa
    17041 agctcctgta aaagcacctt cttcatatcc aaaaagttca ctttcaagta aattttctgg
    17101 catagctgca cagtttatcg ctataaatgg ctgactatgt cttggtgatg cattatgaat
    17161 agactgagcc atgagttctt ttcccgttcc actttctccc gttataagaa ttgtataatc
    17221 agattcagct attttcatac ctaatttctt agttctttcc atcttcgttg aaactgtttt
    17281 tatatcatca aaagtatatc tagcaacttg tcccttttct ctaagcttct ttgataggtt
    17341 ttgctccaat tttcttatgt aagttatttc ttgaatacaa aaataatatc cagtaaccct
    17401 tccaaaactc tctatattat acttatttac gtttaagtac ttattattaa attttataac
    17461 ttcatcatgt gccttactca aactaaaaat ctttttaata ttctcattct ctaattcatc
    17521 tatatttttc cctataatat tactttgaat atctagtata tcccctaaac tattattgca
    17581 aataattatg tttcccttat ctgataccat tgccatacct aagtttgata aatttattat
    17641 agaatttaat tcatctgctt ttatagtaag ttctttatat ttagtattta ttcctgaata
    17701 taaactaatt atttcatctg tatacttaat tagcctttca gtaatttctt tatcatccag
    17761 tttgagtttt gctattattt gaataaacgt tgaactatca atatacctat ggcctaaatc
    17821 aataacttct tctatatatt ttggaactaa acttgcctct cctggcgtta tagctatctt
    17881 aatatttcta tattcttcat tgggattgta tggtataaaa ttcagatgat ttattcctat
    17941 attgtataaa ttagatattg tttccaatac agtatgctta ttatcgttta ctactaatac
    18001 atctattcct tctggcaatg aaaataactt atatatatcc ttttgcttta tgctcctatt
    18061 tatagttatt atctttgaga catcttctac atattttttt atttttaata ctctatcatc
    18121 tatcattacc aatattatgt catcttttat taattccttc tctgttattt tatttaaata
    18181 ataatttttt atcattactt tatctttaaa tatcatttct agatttttat ttaagaaaca
    18241 ttctaattta gacaacccat cagttactac tgctattgtt ttcatttgat tactcctttt
    18301 aaaatatact ctactctttt ataatataca tctgattttc actttaacag cacaaaaaat
    18361 tgtacattta gtatactaac atattccttt attagtttta tgtccctaaa tatcatagtt
    18421 gcaatatcta tcatatttct taaacttcta taaagcaaaa attgtgccaa attaataatt
    18481 ttcttaattt tattctaaag ttcctcaata gtatttacag acttagcact tatagcttat
    18541 aagtctttat attattaatc tatttttata ggttaattgt acaaatcata tatcactttt
    18601 acccattaaa tgcattataa aaaagatgga ataacgattc gtcactccac cttttttgta
    18661 ataaaaaatt gtatatataa acactattta ctactcttct aagtacaaac attatctaca
    18721 tactataacc tttcaccatt agattctatt acttgtttat accagtcaaa actctttttc
    18781 ttaatcctag acaagtctcc acttccatca tcatacttat ccacgtatat aaacccatat
    18841 ctcttggcca tctcaccagt agatgcactt actaaatcta tacatcccca cggagtatat
    18901 ccaaataaat caacaccatc ttctacagct tccttcattt gctctatatg tgcttttaaa
    18961 tactctatac gatagtcatc atttatcact ccattagatt cttttttatc ataagctcct
    19021 aaaccatttt caactaccat cataggtatt ctatatctat cataaatttc atttagtgca
    19081 tatctaagcc cttcagggtc tatttgccat ccccattcac tagacttaag atatggattt
    19141 ttcactccac ctaatatgtt gccacttgta ttatcttctt tagaatcact acttacacat
    19201 gtagacatat aataactaaa tgtataaaaa tctacacaac cttcttttaa aatttctaaa
    19261 tctccttttt ccatttttat ttcaatatta ttttctccaa aatatctatt catataagtt
    19321 ggatattcgc cacgcacttg tacatctcca cagaaataat tcattactct actatctctt
    19381 tgagttttaa ctgcatcatc tggattacaa gtataaggat acattgttgc aaatatttgc
    19441 atacatccaa cttgataatt tgaatctatt tcatgagcta acttaacagc cttagcactt
    19501 gctacaaatt gatgatgtaa cccttgaaaa cgaagttgag gtatatctac ttggtttata
    19561 aaatctgtag tcccttcatt taatattcct tgtgataagt agcctcccat aggcattgta
    19621 gctgaattta tttcattaaa tgtcagccaa tattttactt ttcctttata tcttttaaat
    19681 attgtttcac agtaattcat atacaagtct attacatctc ttgaaaccca tccattgtat
    19741 ttctctgtta ttgcaaatgg tatttcatag tgagatattg ttattaatgg ttctatatta
    19801 tattttaaac attcatctat cacattttca taaaatttaa gtcctgcttc atttggttct
    19861 ttctccattc cagttggaaa tattctagtc catgctattg aaaatctaaa taccttaaat
    19921 cccatttctg caaataaagc tatatcttct ttgtatctgt gataaaaatc tattgcttca
    19981 tgacttggat aaaatgttcc tttttctata actctcgtta ttcttttact tactttttga
    20041 gaacctccag tacacatatc tgaacaagaa ggacctttcc catctaaatt ccatgctcct
    20101 tcacattgat ttgctgctgt tgctccaccc cataaaaaat cttttctaag tgccataatt
    20161 ctacctccaa taatttattt atagtaactt tattttaaaa taaaaataca tatatataat
    20221 tcttaattaa tagaactctc ttttacgcta aaacagttat caattcctga ctattattta
    20281 catgcttttg tgtattttct aaaatatcca cataatcaga ataattagta acaactactg
    20341 gtgtttctaa gcaatatcct tcttttgaaa tactttctat gtcaaaagtt attaatatct
    20401 gacctttttt aatcttatcc ccttgattaa caaaagattt gaaatattta ccttccaact
    20461 gaatagtatt taaccctata tgtatcaata gttcacaacc attatcagat ataattccta
    20521 ttgcatgttt tgttggaaat aaagtcatta cagtcccatc aaatggtgcc actacttttc
    20581 cttctttagg tgttattgct acaccttttc ccaatatacc tgttgaaaac gctgcatctt
    20641 gtatctgctc caaagccttt acttcacctt ttattgggct atatactact tctcttttgt
    20701 ttttttctat aacgccttgc ccattatcat ctttagaaat ttctactata gcatcatctt
    20761 tccaaaaaaa taatgttaaa acaaatccta ctacaatagc tactattatt gctattatag
    20821 ttgcataaac acctttcata tctccagttg ttggatttat ataattaggt ataccaaata
    20881 ttccaagtcc acccattaca taacttttta cattcattat ccccattaca gctcctgcca
    20941 caccaccacc tacacagcta tatatgaatg gtgtttttct tggtaaagtt attccatata
    21001 ttgcaggctc tgttacacca catatccctg aaataactgc aggtatacac agctctttta
    21061 tcttcttatc ttttaattta aagtacattg ctgctactac tgctgtttgt gcaaaagatg
    21121 gtacaaatgc tcccactaat attgtgtcaa accccatagt cataaggttt gacatagcta
    21181 ttggtactaa tccccaatgt agaccaaata ttacaagcac ttgccacaat aaaccagtta
    21241 atgcaccaca taaaattggt gaaaagttaa ataaagctaa aaatccattt ccaactatat
    21301 tagaagcata ggtagctata ggccctataa ccataaatcc caatggtaaa gaaactaata
    21361 aaactgccat tggtacaaag aaattcttta ctacatctgg tattatttta gcaaacactt
    21421 tctccaactt agctgctaat aatactatta aaattactgg tactactgtt gaagtgtagt
    21481 tcattgctat tactggtaat cctaagaaag ttatatatac tggtgattca aatattgttc
    21541 cagtaaatag attgtataaa ggttgacctg tagatgctag agtatctaat tgaatacctg
    21601 aatagcataa aactgcacct ataagcattc caataaatgg ttttaatttg aatttcttag
    21661 cagctgtata tccaagaatt attggcatat actggaacat tgcatctcca attgcattta
    21721 acataatata tgcaccatca gtttctccat acaaacccaa tgctgtaaat actgcattaa
    21781 atccttttat cataccagca gcacacagaa ctcctaatat tggttgaaaa actcctgata
    21841 ttatgtctat aaacttatta agtaatcctt ttggcgcatc tgagtctgaa ttatctattg
    21901 tatctcctcc taatccagcc aaatcgcaca caacttcata aacatctgga acatgattac
    21961 caataactac ttggtattga cctgcacttt tcattacagt aactatacca tccatttttt
    22021 ttagcacatc atcatttgct attgactcat cttttaattt aaaacgtagc ctcgttatac
    22081 agtgagataa actgctaata ttatcctttc ctcctacatt cgcaatgatt tcttttgata
    22141 gttgttcata ctttctcatt ttttctcctc cattttcttt ttgaaatatg aaggtttggc
    22201 caacttaatg tcaccaccca atatatataa acctaattat taggatttat atctgactta
    22261 atacttttac ttaccactct ttcaacgtga atagttaagt ataatttttc ctcatctgtt
    22321 aaatcgtagt tgtatttttt atgtataaat tcatccaact tttctatgaa tttataagca
    22381 tttttatatt taacttttat tacatttaat aaatcatctt cattattttc atgtaaatta
    22441 ttactaacaa ttcgttctgc aaaatacttt aagtgagtaa taaatctatg ataataaact
    22501 gaatcttcat caaatactat tctgtaatgg tatttaacca tatttgaaat ttcttgtatt
    22561 atttgtgtaa tctcatatat agtttttata ctttgatcca tttgtgcatt aactatatgc
    22621 agtgctataa atccagcttc atcttctgat agtctaattt caaatttttt ttctatataa
    22681 tccaatgcct ctaaccctat tttaaattca ctcttataaa atctttttat atcccaaagt
    22741 aatacatttt ttacacttac tccttcacga gctctttcta ttgcagtata catatggtct
    22801 gttaaagaaa tataaatact atcatttaat cttttcccta gtttttcttt agcatataaa
    22861 attatttcat ctgataattc catatatctt ataggaatat ctgctattag ttctttaaat
    22921 ttatcagata tatttgggtc tgaaagtttg aatatcttat caattttatc ctttgatata
    22981 tgctctcctg tacgtttttt ataagctaaa cctctcccca taactactat ttccttatga
    23041 ttttcatcag ttgtaataat tacattatta ttgagtattt tttcaataat cattgtgatg
    23101 ccccctttat tagcattaag ttaaaataaa tcttttttaa ttatttagaa tatttaaaat
    23161 gtaatttatt acataaaaaa aaacctattt attacacatt aaatagactc ccatgagtcc
    23221 tgagtaataa ataggtttag cttgtattta aacaatcact atccgtttgt attttatttt
    23281 aattattatt tattatatgt tagcaaattt attttttagt gtcaactttt tctcaatatt
    23341 ttaattttaa ataaattata taaattgaat cttcaaagta ctatttttat caataaacaa
    23401 aataaaaaag gtattacttt ctttaagtaa tacccattta tttttaattt aagtggtttt
    23461 tcttaatctc atcaagtagt ccatcttcta aataaatttc taatgcacat cctaccattg
    23521 cctttactgc tttgtgaagt ttatcataag cttcctcaga atttgcataa tttagaaatt
    23581 ctttttcatg aacatatacc attggactta tatctaaggc tatttctgta tacatagtag
    23641 ggcaaacttg acttacatta cctatatctg tagaacctac tggaccatct ttaccttcta
    23701 atatatctgt tatacctgcc tcaatcaaat tattctttgt tatcttttga agtactttgt
    23761 tatttattat gttgtcaaaa gaattttcaa agtatctata agaaagctta gctcctgtca
    23821 ttaactctgc accttttgca cagtttataa cttttttagt tacttcatct aaataacttc
    23881 tttcagcagc tcttacgaaa aacttacaag ctgctttttc tggaactata tttggagcct
    23941 ctcctccatt tgaaactata ccatgtattc taacatctga ttttacatgt tgtcttagtg
    24001 catttatccc agcaaaagta agttgtactg catctagtgc attgactccc atatgagggt
    24061 gactagctgc atgtgctgat accccttcaa aactaaactc taatgaatct atcgccaaag
    24121 ccttacagtt tatattatta aaagcttcta tatgcatttg ataacttaca tcaacatcat
    24181 caaaagctcc tgccttaact aaatcacatt ttcctcctgt tgtttcttca gctggtgttc
    24241 ctattagtac aatttttcct ttaaaatttt cttttaactt acttaatact atacaagctc
    24301 ctagtgtaga tgctgcaatc cagttatgtc cacaagcatg agctggttct ttattttctc
    24361 catatccagg aagtgcatca tactcagcta aaaatgctat ggtaggtcca tcattatctc
    24421 ctaattcagc tctaaaagca gtctccatat tacaatatgg ataaactgta tcaaatccat
    24481 attccttcat tttttctact aagtattttg atgatatgta ttcttcttcc cctaattcag
    24541 gattgttaaa tataaaatta caaacttctt caatttcttt tccaagttca ttctctatct
    24601 cataagctct cttctttata ctctctatca taatttacct cctactagaa tcctagatat
    24661 aatcctattg tcaaaaatgc aattacaaga attgttaata ctaccattaa aggaattacg
    24721 aatctaaccc actttgacca aggaatattg gctactgcta gtgctcccat taaaacacct
    24781 gatgtaggtg ttatcaagtt agttacacct ataccaaatt gataagctgt aactatcatt
    24841 tgtcttgata catctactaa gtcgccaagt ggtgcaagta caggtattgt aagtgatgca
    24901 agccctgatg ctgatggtat taaaaatgct attaatcctt ctattaagaa agttaaattt
    24961 ataaatatag tttttggtaa tccatttaat aaatttgctg cagaatttaa aattgtatct
    25021 attataaatc cattttctgc tattattacg attccacgtg caaatgctat acacaatcct
    25081 gctgtaatta aatctcctgc tccacttata aatgaattaa ctatctcatc ttgtttaagc
    25141 cctgatgcta ttcctgatat tatacctata gctgtaaata tcattgcaat ttcagttatg
    25201 taccattcta gtcttaaaac tccatatatc ataatcgcca tacctattgt gaaaatggct
    25261 attaccatgg cttctctttt tgtaaattcc tttatatttg tatcactatt aaccattaat
    25321 tcttgattta gtgatatatc atgtactaaa gattttttag ggtctttttt aactttattg
    25381 gcatacatca taacaaatcc tatagatata gccatatata ttataaacat aacaactcta
    25441 aactctattc cagaacctgg tactatttgt gataatgctt gtgctattcc tacagagaaa
    25501 ggattcgtag tagctgctcc aaatccagct gttgctccta taaatactgt ggccactgct
    25561 gtcaatgaat catatcccat actggtcata agtggaataa atatcatata aaaaggtagt
    25621 gtctcttcac tcattccaaa cgtcgtccca cctagtccaa atagaatcat tgaaatcggt
    25681 attattaaaa attgaaactt cttcatttta tttacagtat gagctataac agcttctata
    25741 gctcctgttt tattaactat cccaaaagct cctccaacta ttaaaacaaa tccaactact
    25801 tcagctgcat ctataaaccc gtttataggt gctgtaaata catcagtaat tccttgtgga
    25861 tttgatggtg ctttttcata agttccagct acaacaactg accttccgtc tatatctact
    25921 ctttcaaaat ttccacttgg cactatccaa gtaagaattg ccattaacac tattagcaaa
    25981 aatattattg taagtgtctg tggcatagta aactttttct tttttaaact gctcattttt
    26041 aatctcccca ctttttaaat taaatatttt attattgcat ccctttatcc tattttgtat
    26101 agatgtaaaa aagctcaaca tggatacatg ttgagctaaa tgtgctaaat acaacatacc
    26161 tgcatcttcc ctttatcttg tttaagatag ctctccatca aaattcggga taattttgat
    26221 gacagtactg tacctattaa atacagtccc agcactagct tcggacacta gcacttcggc
    26281 acttactcct tttatattgc ctcattggtt tccaacctct tcaatattaa tcttagtaaa
    26341 tgcaacctct acctcaatct gtttgttaga tgaggtaatt cttattaatt tttattaatt
    26401 caaagtaatt gtagcataat atgtcgagat tgtaaatatt ttcagtataa taattcttac
    26461 tttatgattt cattccattt ttcacaaata attttttctc catataattt aaatactgta
    26521 gtatatttta aatacacaca aactttccac aaattttaaa ttattataat acctttataa
    26581 taaaaaataa aagctatgta aacttatcaa tttacacagc tttatataca ttaatctact
    26641 ccaagtacag ctttaagctt tgatgctatt gtaataactc gtggaccaaa tataacttga
    26701 actgagtttt tctttttaac aactccactt gcacccaatt catttaccca gaagccatct
    26761 tcatagaatc catcaattga atttagctct accctaagtc tagttgcaca gtttgtaaca
    26821 ttttttatat tattacttcc tcctaaacct tctattatag aatgtacaag ctttgtatct
    26881 ttatcatcta cttcctcttc tactgcattg ttgtatgctg ttttaccagc atctacagat
    26941 tgtctttctc tatattcttt cttactataa agcttaactt cttctgaact tcttcctggt
    27001 gtttttatat caaacttctt gattgcccat gtaaatatta tataagtaac tataaaaaat
    27061 attggtatca aaaataataa tggtaacgca tccacttttt gtggttgtaa taaattagga
    27121 aacatatttc taaatgattc tcccattata gaaacattaa acatttctgt aaatacatac
    27181 gtcaatcctg ccagtggtac atatgctaca aaatacaata atggtgcaac aaataggaat
    27241 gtatactcta ttggttccgt tacccctacc aacatggctg ttactattgc tggtatcaat
    27301 atacttattg cttttttctt attagcatta tcagccaact tatacatagc taaagctgct
    27361 gctggtaata ttgcaaaatg tattaataaa cgacctgttg tgaagttacg agttatataa
    27421 gatagtgtat ctgggtctcc catttgagct aatcttatat tattaacacc ctcgtaaatt
    27481 gctccaccta cttccattgt tccacctact cttgtatatt ctatagggaa tgcaattaag
    27541 tgatgtatac caaatggtaa taatgcttta tccattgctc caaaagtaaa tgttcctaat
    27601 aatccactag aacctatcca attaccaagt ttagataatg ccaaccctac tggtggccat
    27661 ataaagtaca ttgctgtacc caatactatt gatgctataa acatcataat cattgaaaat
    27721 cttggacctg agaaaaaaga taatgcacta ggaagttcta tgtcaacaaa tttgttatgt
    27781 actgcactag ctacaaatcc agctattata gctccaaata tactacaatc atatgaaaag
    27841 attcctaaga aagaaccata taaagaactt cgactatatg cttctgcctc tcctaatcca
    27901 gatgccataa acgcttctgc tgtaactgta tctgaattta taccatttgc tgctaacaat
    27961 gtacttataa ctgtgtgcat tcctataaat aaaacaattc ctcctaatgc accccatcct
    28021 ttttcctttt tagataatcc aaaggctata cctgtaacaa agaatattgg taagtatctc
    28081 attaccataa atcctaaatc gtttattact ttaaagaata catttataaa tgacccttct
    28141 tttattagtc cgctaagccc taatgcagaa acgttttcca tatttgcaaa agctgaccct
    28201 aatcctataa atactcctgc tacaacaagt aatataacag gtatcatcat tgctccagaa
    28261 agtacttgta atttatcctt catagtatta tttcctccat ttttattgaa atgccaggct
    28321 atataatgca tatatatata cttctattgc tttgtataat gtatctatac ttatattttc
    28381 atttgcctga tgtgaatttg gattatcccc ctctattgtg ggtccaaatg caactccatt
    28441 ttttaacact cttgcataag atgcagctcc ttttgtaaaa agttcggctt cttttccaaa
    28501 accttgttta tatgcatttg ataatttatt tattaattca ctatctggtt ttacatacag
    28561 taattttaaa tccttatata tatcaactat taaattttct ttttttccaa tttcattaat
    28621 tctattagtt ataaactccc aacttatacc cttaggatat ctaaagtcta ttttcatatt
    28681 caattcattt ttctctaaga agatactcat tatacatatt gtagaaactc ccatatctac
    28741 atcttcttta tacatcccta atttttttcc atgattatca tctgtaaagt atgaatttaa
    28801 aatatccctt attataacgc ctttatcatt tagtttttta attttctcta aatcttttgc
    28861 taaactaaat gcacagttat atgacctgtg tggatttctc gataaagccc tttctcctgt
    28921 atatcttact aatactttac cttcatctaa ttcttctatc tctgtataat aagctaatga
    28981 ttctactaaa tctttcttat cattagtttt aaaaacagcc tcaattttgt cacatacaaa
    29041 tccatcttct ttgtttgact ttatatcaac taaattgtga tttctaaatt tatctttatc
    29101 tattttcttt cttagattga agtataaaat acctttttct ccatttacta ttgggaagtt
    29161 tccatctgga gaaaatgcaa attttggctg ttcattgaca ctaaagtaat gctccataca
    29221 ttcccaagtc gtctcttcag ctccacccac tatcaatcta atctttctct tcggcttttc
    29281 attaagttct cttaagaaaa gtaatgcata taaaatccct atcaaaggtc ctttgttgtc
    29341 attaactcct ctaccataaa gatagttatc tttttgacat actttaaaag gtttactctt
    29401 ccaaagttct ttattatata ttggcaccac atctatatga ttaagcaccc ctactacttc
    29461 ttctccttct ccatattcta tatgaattgc atatccatca aagtctttta caacaaaatc
    29521 tttgtctttt gctatttgaa taagcttatc gaaggcattt cttatttcta tcccaaatgg
    29581 ttgatttata tctgttgtac tttcatctct aattgaaggt atttcaacta aacttctaat
    29641 atcatttatg atattttctt gattggattt taaataatca ataattagtt ctttgtttac
    29701 tatcatctta attatttatc acccctttat attaatttta caaagcattt cagttcatat
    29761 ctacattata aattttgaat attatttttt caatatttca aatacttctc taagttacca
    29821 taatgatacg gtaaacaatc aacagattat gacaaaatca tactatacct attactaata
    29881 ttttaactta tctattacgt cttttttaat gtaagtttat tccaaaaata cataaaaaaa
    29941 gatgtagcct tagctacatc ttcttatatc tattcaactt ccattattat gctattaata
    30001 tctacatttc caggttctat cctatctttt actgttctct taacagaatc agcatcatcc
    30061 attataacta caggagttat tatatttaaa tcatttgacg ttataaaatc taaatctact
    30121 tccattatta aatctttagc ttttacctta tctcctgcct ttaccttaac atcaaacggc
    30181 tttccttcta gtgacattgt ctctaaacct acatgtatta atatatttgt attatcatta
    30241 ctcttaatca ttattgcatg ctttgtatca aatacattga ctatttcacc atcaacagga
    30301 gaatataact taccttcact tggtattatt gctactccat ctcccatcat cttttgggca
    30361 aaaactgcat ctggaacatc ttctaagttc actaaatttc ccttaaaagg gctatatatt
    30421 ttctcaatct tattttcttt tttcttaaat atattaaaca taacacactc tccacattat
    30481 aaaattttat gataatattt ttcttaaagc ttttgctaca ccatcattta cattagtatc
    30541 agttacaaaa tctgccatag attttacttc atctgtagca tttcccatag caataccaag
    30601 acctgcaaat ttaatcatgg atatatcatt ttcattatca cctatacaaa taacttcttt
    30661 gctatctata cctaatatat cacaaaattt tttaactgca ataccttttg aagtaccttt
    30721 actcataact tcaaagttta tctttccaga acttactact tctaaatctt cttgtttttt
    30781 aaattcttcc tttgcttctc tcaaagaatc tacgttttct gagaaaagta tacattttaa
    30841 aatttcatta tcagcttttt ctaataaagt ttcacaactt gcattttcta ttatttcaat
    30901 tctgtcttct tctttatttt tactatttat taatctatat ggatgttctt cacctatttc
    30961 attgttggat ataactattt tacagccttt aaaatgtttg tttaaattat acttttcacc
    31021 tattgtatag attttcttta gagcttcttt gctcaaaacc ttcttatact catatcccag
    31081 taatttaaaa tatgtcccat tagttgatat aatatatata tcatccccta aaacacttgt
    31141 aaaatatttc atagcattat aaggtcttcc cgtaactaag gctaccttga tacccttttc
    31201 catggcttct tttagtgctt taatattttc ttctgatact tcaaatcctt tacccatcaa
    31261 agtaccatcc atatcagtac aaattaattt atatcgcatt tgtatcacat cctagtaaga
    31321 tttttctaat atttcaacaa ggtcttcttt ctttccaaaa ggtaaaaatc ctaaaactgg
    31381 acagcttgtt atttgttcta attgttcctt tgttacatta aactcagaca tttttgtctt
    31441 aagccccact ctctttaaaa aactttctat ttcatttcct aaagttttag ctgcttcatc
    31501 atcttccact ttttctaatt cttggtttag tattctcgct actttggcaa atttctctat
    31561 attatcctta tagaactttt ctgcaaattt tgggaacact atagccaaag cctcaccatg
    31621 aggaatatgt gtaactcctc ctattatttc acttagtgga tgtggtgctg ctgctccagc
    31681 atttgccagt gaacttcctc ctaatgtatc tgctactgct aactttgttc tgtattctat
    31741 attattttta tcttccatta ctttaggtag atagttaatg actaattcca tagatttttc
    31801 agacattatc tctgtaaaat cattagcatt tggatttata taactttcaa atgcatgagt
    31861 aaaagcatca aatgctgttg atgcagtaat tctctctggc agagttaaca taagctctgg
    31921 gtcaactata cattcttttg agaaacaatt ttgatgaaat attgtatttt tctcgcttcc
    31981 tctcgatatt actgctgctt gtgtaacttg gcttcctgtt ccagaagtag ttgatacagc
    32041 tattaatggt aattcttttt cacttacctt atcgtatatt ttaaatggat ttgtatatgt
    32101 actaaacata taatcccaat ctattttttc taaaccaaaa gtcaatgcta atacttttgc
    32161 agtatctata cttgaacctc ctccaacagc taaaacaacg tctacagatt cttttttagc
    32221 taattcaaac ccttcgttta ttaattctac agttgggttt ggctctactc tctgaacctc
    32281 ccatgactaa agtcacaggg ttcctgcttc acagaatttt gcatactaaa atatgtctta
    32341 ctaattctcc acaggccatc cccgtagttc ctacggttct tacataagtt atttattttg
    32401 aattgttatt agtcttaatc cttcttttaa tatatttata cttgcattta tatctctatc
    32461 gtgagtttca ttacaactag gacaaatcca ttctcttata tttaagtcct tcacttcctc
    32521 gtttttatac ccacatttat tgcatatttg tgaacttgca aagaatttac ctacctttac
    32581 aatttgtcta ccatgccaat tagccttgta ttctaattga cgaataaatt ctgaccatga
    32641 tacatctgaa attgagcgag atagtttacg atttttaatc atattcttta cttgtaaatc
    32701 ttctatgcaa ataatatcat tctcttttat taatttagta gataattttt gcagaaaatc
    32761 atttctttga ttagctatat gttcttgaag tcttgcaact tttaatcttg ctttatttct
    32821 atttaaacta ccgattgttt ttctcgataa ttctctttgt aatttagcaa gtttgtttaa
    32881 tgacttctta agatacttag gattttctat aaattctcca caacttgaga tacaaaattc
    32941 tttaattccc aaatctaaac ctatatgatt attagtattt tcaaatgctt caatatctac
    33001 atcagtacag cataatgata cataatatct accacttggt tctttagata tagtagcatt
    33061 aagtattcta ccttgaggta cttgtttatc ccttatctta accataccaa gtttaggtag
    33121 ttttatatat tgaccacaat acataatgtt tccatttgta aagttagttt tatatgaaaa
    33181 tctattaatt ttctttgatt taaatttagg aaatcctgct ttttctttaa agaatttttt
    33241 atatgcatta tctaaatctt ttaaggcgtt ttgtagtgaa aatttgtcag gttctttaag
    33301 cc
//
LOCUS       DAEHWM010000037        32264 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.038, whole genome shotgun sequence.
ACCESSION   DAEHWM010000037 DAEHWM010000000
VERSION     DAEHWM010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 32264)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32264)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32264
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.038"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            127..1473
                     /locus_tag="KNP36_001837"
     CDS             127..1473
                     /locus_tag="KNP36_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0873711.1"
                     /translation="MKDLTTGHEGKSIFFFAMPMLIGSLFQQLYNTADSIIVGRFIGK
                     EAMAAVSGANPIMFLLVAALMGVSLGFSILVSQFYGSGDLKKVKATIDTTYILLFIGS
                     ILISILGIVFGGPMLKLMNTPESVFAQSKLYLTIIFSGILFSAGYNSVSAILRGLGDS
                     VTPLYFLIIATILNIVLDLTFIVVLRMGVEGVALATIMAQAVSFIISIIYLNKKHEVL
                     KFKIKGIVYDNKIFKDGLRLGLPSGVQQMLFSIGNMALQFLVNSYGTSAMAAFGAGLR
                     IENFISLPIMNLGSAVSTFVAQNIGAGENERVKKGIRESIKMTLVLAVTVIALILLFR
                     ENLIALFNTDKDVIKIGSSYLFIIGPFFLFIGTSFVLSSAMKGAGDSMFALISSIVSL
                     WLGRLPASYMLSKFFGTDGIWMGIPFGWTLGLIVTVIYYKKGHWKTKAIVNHRINE"
     gene            1551..2945
                     /locus_tag="KNP36_001838"
     CDS             1551..2945
                     /locus_tag="KNP36_001838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HBF0873712.1"
                     /translation="MGIILKPKQFYMTVIATIILYFSLNYSFNIKFSICLSFLTILIW
                     AVDSVEKTFVALFFVILAFIFNIAPIKVILQFLFTENFYIIILAYIITNAVTKTGVAK
                     IISEKLILNTVNTPKKMILLSYILGILLIFFIPQPFPRVILVSAFYKEFLKEQQITED
                     SKSILLFSIFTASTFTSMFFVNGDTLLNYVVLELGNCNINWGQWAFYMSVPTIITCFI
                     TYFLFIFVFKKELHSIKFISNENLEGNKLHFSYSNLKKEFNLLNKEQKHVFLCLGIMF
                     FMFLTQFIHNINTLIIMSICVLLLLLRKIVGFSTLKEINWKVLIFFIAAFSIGGVLKY
                     SGVVDIMGNYLIKFIPNSSEIISILFLITLTIILNICLGSAVTTSSVVIPLLGSLHIL
                     KENSVTLCLFVYIIVSIQYILPFHHATIMVGHGENLYNSKVIFKYGLTLIPLTYFIII
                     CITFPWWKFIGLEI"
     gene            complement(3067..3741)
                     /gene="fsa"
                     /locus_tag="KNP36_001839"
     CDS             complement(3067..3741)
                     /gene="fsa"
                     /locus_tag="KNP36_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HBF0873713.1"
                     /translation="MQLILDTGNVEEIKELCTCLPIDGVTTNPSIVSKEKKNFKQLIN
                     EIGEIIGEDMPIHAQVLSTKYEEILEEALYISSLRKNIYVKIPVTQDGLRAIKDLHRK
                     GVKITATAIFTAHQGFLAAKAGANYIAPYVNRLDNISGDGVAMVSELIKIIDTYKMDT
                     KVLAASFKNAQQVIELMQHGVHSVTVPYDICKSMMNHPLTDWSVGKFIEDWENTFGKG
                     SKTNNI"
     gene            4015..4779
                     /locus_tag="KNP36_001840"
     CDS             4015..4779
                     /locus_tag="KNP36_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HBF0873714.1"
                     /translation="MFAEERIQAILNILKKEGRVTVKELSSKFNVTEDCIRKDLKNIE
                     KISSIRRIYGGAVLARETLENQDTKDRKEINIPTKKIIAEKAFNLIEDRETIFLDIST
                     INILLAKLLAESNKKVTLVTNMLDILNVVTSKPNNLNIISTGGLLNLSLDGFVGTPTI
                     EFISKYKFDKTFMGSCGVDVFNSSLTTFEIEDGLTKKAIINSSKKVFIVMEDKKFKFD
                     GNFKFAHLEDISSIITEKTPTPDIVDILSEFNVNVL"
     gene            complement(5068..5289)
                     /locus_tag="KNP36_001841"
     CDS             complement(5068..5289)
                     /locus_tag="KNP36_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873715.1"
                     /translation="MDRLKRDMKNMKEDLKEGVKKTAYVMKNTAEDLKDDAQGAMVNL
                     EMKKDEMMERYEQKKFSKELEKQMKNEMK"
     gene            complement(5690..6967)
                     /locus_tag="KNP36_001842"
     CDS             complement(5690..6967)
                     /locus_tag="KNP36_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor histidine kinase"
                     /protein_id="HBF0873716.1"
                     /translation="MRRIFDKWEKLSIKYKLFSITTSLLIALALIIYLILYFLLPSYY
                     HEYKIESLQESLKSLVDSSIHFDTYTLEERLYYMAKDQNLAILLKDNQGKIVYGKNEV
                     VILRYSKYMINSLEDEYRTSIPIYTKDAKDGPYTLELVMPLQPIDEANEVIRKLMPYI
                     ISIAILIAIIGAYIYSIVITKPLINIIESEREQEYRRKDFVATISHELKTPITIISGQ
                     IEGMIYSVGKYKDRDTYLKKSYECTQELKDLVNEMIEVSKSEILEKDLKLVSINISEL
                     LNRLVKRQVFLIEEKHMKTILKIEENLEIKADQERITKAINNIINNAIKYSPEESELI
                     IRLYDKNKRISKKTSNQRVVLEIENTGVTIEKRYLEEIFNPFYRIEKSRSRKTGGSGL
                     GLYIVSQIFKSHGFDYSIKNKENSVVFTVEFKN"
     gene            complement(6951..7619)
                     /locus_tag="KNP36_001843"
     CDS             complement(6951..7619)
                     /locus_tag="KNP36_001843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424455.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873717.1"
                     /translation="MNSSILVIEDDSNIQELISEFLSAEGYQVDTANDGLEGIQKFKQ
                     GSYDLVILDIMMPNLDGYGVCKMIRKSSSVPIIFLTALNDEGDQLKGFDLECDDYITK
                     PFSFNLLIKRVEAILRRSNKTINDKFIVFEKLKLDLNTYIAEIDGEPIELTLKEFNIL
                     KALIEKYPQVITREGLLDSIWGYDYYGDTRIVDAHIKNIRKKISLPYIKTVKGIGYTL
                     EKDI"
     gene            complement(7779..10280)
                     /locus_tag="KNP36_001844"
     CDS             complement(7779..10280)
                     /locus_tag="KNP36_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /protein_id="HBF0873718.1"
                     /translation="MSSNKVVESYKITGMTCAACAKAVERVTKKMDGVYDQSVNIATE
                     KLKIEYDNSKVNFDDIKQVVEKAGYGIIKEESNKKIDMKIDGMTCAACAKAVERVVKK
                     LDGVESISVNIATDKANIDYDPSKVKLSQIKAAIEKAGYKPIEEVKNKVDVDEDKLRK
                     EREMKSLFVKFIVAIVFAVPLFYIAMGPMIIKPIGPWPLPEIINPMTNTFNYALIQLI
                     LVIPVMIAGYKFYINGFKSLFSLSPNMDSLVAIGTLAAFLYSLYTTLQIANGQIQGMH
                     HHQLYYESAGIIIALILLGKYLESKSKGKTSEAIKKLMGLQPKTAIVLVDGKEVETPI
                     EEVEIGDILLVKPGTKIPVDGVVIEGYTSVDESMLTGESIPVEKNVGSKVTGASINKN
                     GVIKFKAEKIGGDTALAQIIKLVEDAQGTKAPIAKLADTVSGYFVPIVIAIAVVASLL
                     WFLIGGKDIVFVLTIFISVLVIACPCALGLATPTAIMVGTGKGAENGILIKGGEALES
                     AHKVNTVIFDKTGTITEGKPKVTDIVLNNNVKEEYLIKIASSAEKGSEHPLGEAIVKY
                     GEEKNIKFEKVDNFKAIPGAGIQVTINDESILLGNRKLMNDNNIKLGDLEEKSNILAS
                     QGKTPMYIAVDGNLSGIIAVADVVKESSKKAIEILHDMGIKVAMVTGDNAKTANAIAN
                     QVGIDMVLAEVLPEDKSKEVEKLQNQGKFVAMVGDGINDAPALAKADIGIAIGSGTDV
                     AIESADIVLMKSDLIDVPTAIKLSHETIKNIKQNLFWAFGYNTIGIPVAAGILYVFGG
                     PLLNPMIAAAAMSLSSVSVVSNALRLKNFKAYKRD"
     gene            complement(10564..10755)
                     /locus_tag="KNP36_001845"
     CDS             complement(10564..10755)
                     /locus_tag="KNP36_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1450 domain-containing protein"
                     /protein_id="HBF0873719.1"
                     /translation="MIRVCPNCSNVDVNKLKTLVGEENVKTGCIGQCRAFKKEAVGII
                     DNELEIKETEAEFFEACKE"
     gene            complement(10903..11145)
                     /locus_tag="KNP36_001846"
     CDS             complement(10903..11145)
                     /locus_tag="KNP36_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873720.1"
                     /translation="MLEVTKIIIKYFASESDTFVKEEVCNFEELLKWSHKFIEGKKIE
                     DVLYIKSKENYKVNVIKSLEIKELEIVRKQQIPPYM"
     gene            11357..13180
                     /gene="typA"
                     /locus_tag="KNP36_001847"
     CDS             11357..13180
                     /gene="typA"
                     /locus_tag="KNP36_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HBF0873721.1"
                     /translation="MSQKHKIINIAVIAHVDAGKSTLVDAFLSQSGVFRKNEVVKDCV
                     MDSNDLEKERGITIYSKNCAINYEDYKINIVDTPGHSDFSSEVERVMKTVDTVILLVD
                     ASEGPMPQTRFVLQKSLEFGLKPILFINKIDKKDQRAEEVVNEVFDLFVDLNATDEQC
                     EFPIIYGIAKQGIAKLEMDDDSEDLSPLFKTIVNHVEAYPNYDNEPLQFQISALAYDD
                     YVGRLGIGRIYKGTLKNNTQVAICREDSVVSKGKVSKLSVYEGLKQVEVDEATSGEIV
                     VIAGIPDISIGETICDLDSPLPMEMIKIEEPTLSMNFLVNDSPFVGKSGKFVTTRHLK
                     DRLEKELEVNVGLKVEPLDTTDGYKVSGRGELHLSILLENMRREGYEVGVSKPEVLMH
                     KEDGKLMEPIERVVVNCPEVYSGTIINELNMRKGMMESMSIEGDYVKIEFLAPTRGLL
                     GYRSEFINATRGEGTLVRSFEKFEEFKGEIPSRGNGVLIAQGPGVTMGYSLNALSDRA
                     VMFVDPGVEVYEGMIIGMNSRKDDMVVNPCKNKKMSNVRASGSDDAIKLSPPRIFTLE
                     EALEFIEDDELVEITPDSIRLRKRFLNEHDRLRYNKSRQGK"
     gene            complement(13270..14178)
                     /gene="trxB"
                     /locus_tag="KNP36_001848"
     CDS             complement(13270..14178)
                     /gene="trxB"
                     /locus_tag="KNP36_001848"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HBF0873722.1"
                     /translation="MVDIIVIGAGPAGLTSAIYAMRAGLSVTVFEKNIYGGQVASTSE
                     VENYPAVQKISGVEFSNNIYNQAVAQGVDIQFDEVEEINLEGKVKVVKTSSGEHKAKA
                     VILANGVERRKLGCAGEQEFTGRGVSYCATCDGAFFKDKEVAIVGGGNTALEDALFLA
                     NNCTKVYLIHRRDSFRGEEVLEKSVKARENIEILYSHGVEKIEGEKTVSKIEVKNLKT
                     EEKRTIDVSGIFIAIGLKPNNKMFENVLDLDEGGYIISDESCITSVEGVYVAGDSRTK
                     FLRQIITAASDGAIAAVQAANYINVE"
     misc_binding    14980..15211
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            15319..16800
                     /locus_tag="KNP36_001849"
     CDS             15319..16800
                     /locus_tag="KNP36_001849"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HBF0873723.1"
                     /translation="MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELIN
                     LVNLTYSQIAFFVLSKFLCDFTEDEIKNCIENAYDEKFDCSSIAPLNKVNDTYFLELY
                     HGPTLAFKDMALTIMPHLLKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKI
                     IVFFPEDGVSPVQKLQMKTQTGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNN
                     YILSSANSINIGRLLPQVAYYFYSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYA
                     KQMGLPINKLICASNDNNVLYDFFKTGVYDKNRTLKLTTSPSMDILISSNLERLLFEI
                     SNRNTDIVNKLLSDLSDKGVYKISDDMEKNLASFYGEYSNEEEVKSTINNVFKNYNYL
                     IDTHTAVAYNCYEKYKKETSDNTKTVIVSTASPFKFSEDVLKSIDCDFKDLDDFAIID
                     RLSSISKIDIPKPIKNLKNAEILHKDIYEKDELKLAIKKFLKV"
     gene            16810..17703
                     /locus_tag="KNP36_001850"
     CDS             16810..17703
                     /locus_tag="KNP36_001850"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HBF0873724.1"
                     /translation="MLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGC
                     EDAYKNENNLVYTSMKYFFDRVKPEKIPAGIKIKIQSEVPICRGLGSSASCIVAGVIA
                     ANALSGANLDKNQLLNIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPEELK
                     FCAMIPNFKLSTEKARGVLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKL
                     HQDYRGTLIENYNDIVEKSEQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKL
                     KSDWEIKELCCDSNGAVLNII"
     gene            17827..18888
                     /locus_tag="KNP36_001851"
     CDS             17827..18888
                     /locus_tag="KNP36_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015617764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitronate monooxygenase"
                     /protein_id="HBF0873725.1"
                     /translation="MIIKELIIRDLVAKVPIIQGGMGVGISRSSLAGAVAKLGGVGVI
                     SGVQIGYDEEDFETNTINANLRAIKKHISKAKEISNGGIIGINFMVAMKEYETYVKEA
                     VKAGVDLIISGAGLPNKLPSLVKGSNVKIAPIVSTAKAANVILKMWDRKEKTTADLIV
                     VEGPKAGGHLGYSNEELDNIDSIDYDKEFVEILKVANTYGEKFGRNIPVVAAGGITSS
                     SDVKKYIDMGASGVQVGTRFVATYECDAHENFKMAYINASEEDVHIVKSPVGLPGRAI
                     RNKFIEEVKINRPEIKKCYNCLIPCNPKETPYCISQALINAVKGDVENSLLFCGNDAY
                     KIDKLSTVEDVINELISEL"
     gene            complement(19043..19555)
                     /locus_tag="KNP36_001852"
     CDS             complement(19043..19555)
                     /locus_tag="KNP36_001852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase family protein"
                     /protein_id="HBF0873726.1"
                     /translation="MSDFKEILAEEIKNNPFGLIGKDWTLITAENEGKVNTMTASWGG
                     LGVMWGKDVAFVVIRPQRYTKEFIDNTDKFSLTFFDEDFRKELSYCGKVSGREEDKIS
                     QIGFNIEHLNDTPYFKESKMAIICKKMYSQKLEPQCFIAEGIDGRWYPQKDYHTLYIA
                     EITNVLVKED"
     gene            20075..21010
                     /locus_tag="KNP36_001853"
     CDS             20075..21010
                     /locus_tag="KNP36_001853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HBF0873727.1"
                     /translation="MIRYYKTIDSKLEKLSFFEDGCWINLVEPNHSEINEISNLLNID
                     VESIESALDEEERSRIDVEDNHTLILIDIPVDESDSNSSHYTTIPLGIILTEEAIVTV
                     CDAQTKILNDFIVGHIKDFFTFKKTRFLLQILHKNAAYYLHYLRKINKMTIIIEREIY
                     KSMKNKELVQLLELEKSLVYFSTSLKSNELVLNKMVRTAGIKKYPDDEDLLEDVIVEN
                     RQALDMAKIYGDILSRIMDAFSAIISNNQNNVMQILTVVTLIFSIPTIISGFFGMNVI
                     NMPFSNNPNGFWIILLITSIICIVITFFMSRNKLL"
     gene            complement(21102..22973)
                     /locus_tag="KNP36_001854"
     CDS             complement(21102..22973)
                     /locus_tag="KNP36_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sel1 repeat family protein"
                     /protein_id="HBF0873728.1"
                     /translation="MKNTKFSIKKIKNISNDPKVVHTKGALLEKMGKMESAIELYKSA
                     ALDNYVKSQYTLGNIYESKKQFKEAEKWYSMAYKSGSEDAAFDLGNMYYKLDGYEYAI
                     YWYEKIANLGYLQAQNNLGVCHFKMKDFVRCEKWLKTAADKNLGKACFNLGVLYTFLE
                     KDDEAYEYYKKGSVLLDDDAKYNLAILNGKKKDNKSTVSLYKQLYKSGHMKGCFNLGM
                     IMEINDNLEDAEKYYKKSADRDDVKSEYRLAYVYDRKEELGDAIYYYEKAIEKNHILS
                     KYRLANLYNRENEIEKAKTYYKMAAEDDITEAKNNLAGIYFEEKDYENAIKYYEDAIA
                     VGCKSSLENLGDLYYQNQDIEKAISYYSRIPNNVSCQIKLGNIYEDLNNIEEAISWYK
                     KASENGDTRSSYRLGCIYESLGNTKNARKYFEMASSKNHMNARIHLGRIYFREGKLEE
                     SKMMFDTPANENNVYAQHMVGLIYDMFYKDYVNSKFWYEKARAQGCVESIYNLGQIYL
                     KLNDDAEAEKYYKEGIKYGSKKCEYMLAGLYYKKSLDMYISLANEEYDNCEEIVEGFP
                     NLNIDFDEVLIPPFKLQEEVIDEEEYVPIYILNIKESLDSMLEGLETEMIIDEEHDS"
     gene            23163..24089
                     /locus_tag="KNP36_001855"
     CDS             23163..24089
                     /locus_tag="KNP36_001855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AEC family transporter"
                     /protein_id="HBF0873729.1"
                     /translation="MNFSNIFIQVAVLFIIILVGYFVRKFNLLDDHCTSKLSTLTMTV
                     FLPSMIISSMQINFDSKMIQKILLLLFTSLIMYIVSIIIAFLLKYILKCNDKKDLGIY
                     QYIVVFSNVAFMGYPVIEAVLGHEAIFYTAIFNLPFNLFSFTLGIYLLSKGSTSRGFS
                     IKSLISPATIAIVIGLFLFVTGLRLPQFINEPLEMLGSITTPISMIIIGSLLANSSAL
                     DCFVNKKLYIVTFIRLLVLPVIVYFILKGWINDKMILAIPVVISSMPAAANTAIMANQ
                     YDSNITLASQCVFFTTLFSVISIPFISILLLS"
     gene            24228..24374
                     /locus_tag="KNP36_001856"
     CDS             24228..24374
                     /locus_tag="KNP36_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873730.1"
                     /translation="MDMDLLFKIVFAIVAIGVSVKIIKTVASLAFKIALILLIILFVY
                     RMFL"
     gene            complement(24479..25003)
                     /locus_tag="KNP36_001857"
     CDS             complement(24479..25003)
                     /locus_tag="KNP36_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0873731.1"
                     /translation="MSKPIDITIRPIRREDAQAFNEIRRTYSVMRNTLALMSDRVDKT
                     EAMLASLGENDYMFVAETNNNGEKDVIGFAGLHVNSSPRLRHSAEIGISVAENYQGRG
                     VGKKLMEQLLDIADNWIMLTRVGLEVIVDNEKGLNLYKKLGFEIEGTKKYAVIRDGKF
                     EDVYIMGRYNKNLI"
     gene            complement(25056..25280)
                     /locus_tag="KNP36_001858"
     CDS             complement(25056..25280)
                     /locus_tag="KNP36_001858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873732.1"
                     /translation="MIIKLTKDNFNFRFKQYEGMFFHAEVVEGMESIRYKITKDKEGT
                     ELKEFGSTHIKDNMIYVPQVEAYIDLNSIK"
     gene            25477..26601
                     /locus_tag="KNP36_001859"
     CDS             25477..26601
                     /locus_tag="KNP36_001859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3810 domain-containing protein"
                     /protein_id="HBF0873733.1"
                     /translation="MSKKTKYFSLILFPIALLLNFIASKVPNIVEKYYSQFIDKIIVQ
                     ILSKVSGIFPFSLYEITMYIIVISTFLFLCCTLSTIFNKKKKLNIYLKNSILNILSIV
                     SIVYFLFVVLWGINYNRIPLETTLINNYNLKNNTSIQSKQYSVKELTKLYKFLVIKAN
                     ETRKLTLQDKNGIVKSNTDYNGVINRAQLGYDNILDILPGVSDSYSKPKYIISSNLMC
                     YTGITGIYFPFTGEANVNIAIPDLYIPCTVEHEMAHQRGFASEDEANFIAYLTSIKHP
                     NIDFNYSGYILALNYTASALSKVDYNAYVDISAGISDSVRRDLKNESEFWQKYEGKIN
                     EISNEFNNSYLKANGVTEGTQSYGKMVDLLLTYYELYPYN"
     gene            complement(27075..27899)
                     /locus_tag="KNP36_001860"
     CDS             complement(27075..27899)
                     /locus_tag="KNP36_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873734.1"
                     /translation="MRYKKISSLPILVVALLITGTTTTFSLSTTNSEKTNVYLANTVS
                     TVTKKVSDIQSSKGLVYNENIPLFINNSKIQYDDTPYHWPSNVISLTNSSEKAIMDYE
                     ITCLAYDKNGKPLELYWDAQNVAADGEVGSVGFSPAGVDYGIVTGISPVSPKSYSHTY
                     RKMQQSPPQDIISMFEKQQGKAWVENWLKEWKQMEKEYAKQNAIAPGKNQNDAFLLFD
                     KWKQSTGEHGVKYIISCVKQVTFNDGSVWKNSAYENWLKSFQGKEVSNSVLENYYK"
     gene            complement(28247..29302)
                     /gene="ispG"
                     /locus_tag="KNP36_001861"
                     /gene_synonym="gcpE"
     CDS             complement(28247..29302)
                     /gene="ispG"
                     /locus_tag="KNP36_001861"
                     /gene_synonym="gcpE"
                     /EC_number="1.17.7.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="HBF0873735.1"
                     /translation="MSYERRKTREVSVGAVKIGGENPISIQSMTNTDTRDADATIAQI
                     KRLEEAGCDIVRVAVPDIKAAKNIAKIKSSVNIPIIADIHFDYKLALEAIEQGVDGIR
                     INPGNIGSIERVKMVVEKCKERNLKIRIGVNGGSLEKELLKKYGSATAEALVESAMGH
                     IKILEDLDFHNIVISLKSSDIYKTVDAYELISKKVDYPLHIGITESGSVHKGTIKSSI
                     GVGALLLKGIGDTVRISLTGDPVEEVIVGKQILRSLGLLNDKIKVISCPTCGRCNIDL
                     ISVVNEVEEKIGSMEKNITVAIMGCAVNGPGEAREADIGIAGGKGEGLLFKKGEIVRM
                     IDGNKLVDELLEEIEKL"
     gene            complement(29485..30489)
                     /gene="rseP"
                     /locus_tag="KNP36_001862"
     CDS             complement(29485..30489)
                     /gene="rseP"
                     /locus_tag="KNP36_001862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HBF0873736.1"
                     /translation="MTIIAALILFSIIVLIHELGHFIFAKRSGIKVNEFSIGMGPKIY
                     SVKKDTEYSIRALPIGGYVSMEGEDEEQISPNSFGNKSILQRFSTIVAGPIFNIILAA
                     ILLVPVFLYIGSPTTKLGKIMPDTPAQAVGLQVGDKINKINGNSVKTWDEVANIINTS
                     SGGELKLSITRDGSDKVVNVTPKNNNGKYEIGIQPQREKDFLGSIVNACKTTVDMTKQ
                     MLTFLGQMITGRVPGGIGNAVAGPVGVIGMVSDAARTGIINVVYLAAVISLNLGIVNL
                     LPIPALDGWRILMLLLEAVRGGKKLDPNKEGMINVVGFGALMLFMLFITYKDILRLFQ
                     "
     gene            complement(30502..31656)
                     /locus_tag="KNP36_001863"
     CDS             complement(30502..31656)
                     /locus_tag="KNP36_001863"
                     /EC_number="1.1.1.267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="HBF0873737.1"
                     /translation="MKKISILGSTGSIGKQTLDVVREHRDKFEIVAISANSNIELLLE
                     QIVEFKPKYVTVFEENKALKLKEMLPKNIEIEVLAGMEGLKIISSLDEVDVLLTAVVG
                     MIGLVPTLCAIKKGIDIALANKETLVTAGELVMKEAEKYNVNILPVDSEHSAIFQCLN
                     GENKKNIEKIILTASGGPFRGKKKGELANITKNEALKHPNWSMGRKISIDSSTLMNKG
                     LEVIEARWLFGVEQENIDVVVHPQSIIHSMVQYTDSSIIAQLGCPDMRLPIQYALTYP
                     DRMESSFERMNFSKFSTLTFEEPDLETFPCLKLAYECLKMGGTYSSVLNSANEVLVSE
                     FLEDKIGFYDIPYYIEKTLEVHSSISEPTLEEILETDRWSRAYVANLIKK"
     gene            complement(31820..32023)
                     /locus_tag="KNP36_001864"
     CDS             complement(31820..32023)
                     /locus_tag="KNP36_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0873738.1"
                     /translation="MISYAPLWKLLIDRKIKKMEFVNISGISISVLGRLGNDKSVSMD
                     TMEKICLALDCKIEDVVEIKKGI"
BASE COUNT        10866 a         5009 c         3860 g        12529 t
ORIGIN      
        1 attatattct ttacatttta aaaaaatata tgatattttg atacaattta tttatagttt
       61 ggatataaag tttatgttaa gattatacta taataaatta ataatttttt tatttggagg
      121 aataaggtga aagatttaac tacaggtcat gagggaaagt ccatattctt ttttgccatg
      181 cctatgctta ttggtagttt atttcaacaa ctatacaata cagctgacag tataatagtt
      241 ggtagattta tcggaaaaga agcaatggcg gcagtctctg gagctaaccc tataatgttt
      301 ttattggtgg cagcgcttat gggtgttagc cttggatttt ctattttagt gtcacaattt
      361 tatggctcag gagatttaaa aaaggtaaaa gctactattg atactacata tatactttta
      421 tttattggtt ctatattaat aagtattctt ggaatagtat ttggtggccc aatgcttaag
      481 cttatgaata caccagaatc cgtttttgct caatcaaaat tgtatcttac tataatattt
      541 agtggaatat tattttctgc tggatataat tcagtaagtg caatacttag aggacttgga
      601 gattcagtaa ctccacttta ttttctgata atagccacaa ttctaaatat agttttagac
      661 ttaactttta ttgtagtgct aagaatgggt gttgagggcg ttgcacttgc cactataatg
      721 gctcaggcag tatcatttat aataagtata atttatttaa ataaaaaaca tgaagtgctt
      781 aaatttaaaa tcaaaggaat tgtatatgat aacaaaatat ttaaagatgg acttagatta
      841 ggacttccaa gtggagttca acaaatgttg ttttcaattg gaaatatggc tcttcaattt
      901 ttagttaata gttatggtac atctgctatg gcagcttttg gtgctggtct taggatagaa
      961 aattttataa gcttacctat tatgaatctt ggttctgctg tttctacttt tgttgctcaa
     1021 aacataggtg ctggagaaaa tgaaagagtt aaaaaaggca ttcgagaatc tataaaaatg
     1081 accttagttt tagcagttac agttattgct ttaattttgc tatttaggga aaatctaatt
     1141 gctctattca atactgataa agatgtcatt aaaattggct cttcttactt atttataata
     1201 ggaccattct tcttatttat tggaacttct tttgtacttt caagtgcaat gaaaggtgct
     1261 ggtgattcca tgtttgcact tataagctca atagtatctt tatggcttgg aagacttcca
     1321 gcttcttata tgctttctaa attttttgga acagacggaa tttggatggg tattcctttt
     1381 ggttggactt taggtcttat tgttacagtt atctactata agaaaggaca ttggaaaact
     1441 aaagctattg taaatcatag aatcaatgaa taatcttttt ataaaatgta ttcacattca
     1501 ttgtattcac ctccattatg atataataaa ttatggaggt gaatataaaa atgggtatta
     1561 ttcttaagcc aaaacaattt tatatgactg ttatagctac cataattctc tacttctctc
     1621 ttaattacag tttcaacata aaattttcta tatgcttatc ttttttaact atcttgatat
     1681 gggctgtaga ctcagttgaa aaaacttttg ttgcattgtt ttttgtaatt ctagcgttta
     1741 tatttaacat tgcaccaata aaggttattt tacagttttt atttacagaa aatttttaca
     1801 taataattct tgcatacata attactaatg cagttacaaa aacaggtgtc gcaaaaatta
     1861 tttctgagaa gttaatttta aatactgtaa atacccctaa aaaaatgatt cttttatcgt
     1921 atattttagg tatactttta atatttttta tcccacaacc atttccaagg gttattcttg
     1981 tatctgcttt ttacaaggag tttttaaaag aacaacagat aactgaagat tcaaaatcta
     2041 tacttttatt tagtatattt acagcatcta cctttacatc aatgtttttt gtaaatggag
     2101 acacccttct aaattatgtt gtactagaac ttggaaattg taatataaat tggggtcaat
     2161 gggcttttta tatgtctgtt ccaactataa ttacttgttt tataacttat tttttattta
     2221 tctttgtctt taaaaaagaa ttgcattcaa taaaatttat ttctaatgaa aatcttgagg
     2281 gtaataaact tcatttttca tattctaatt taaaaaaaga atttaatttg ctaaacaaag
     2341 agcaaaaaca cgtattttta tgcctaggaa taatgttttt tatgttttta actcagttca
     2401 tacataacat aaacacatta attataatgt caatttgtgt acttctttta ttactaagaa
     2461 aaatagttgg atttagtact ttaaaagaaa taaattggaa ggtccttatt ttttttatag
     2521 cagcattttc aattggagga gtgttaaagt actctggagt tgtagatata atgggaaatt
     2581 atttgataaa gtttatacca aactcttcag aaattatttc aatattgttt ttgataactc
     2641 tcacaataat cttgaatata tgtcttggaa gtgctgtcac tacatcatct gtagtaatac
     2701 cgttacttgg aagtttacat atactaaagg aaaatagtgt tactttatgt ctatttgtct
     2761 acattatagt aagcatacag tacatattac catttcatca tgctacaata atggttggtc
     2821 atggtgaaaa tctgtataat agcaaggtta ttttcaaata cggtttaact ttgattcctt
     2881 taacctactt tataataata tgtataacat tcccttggtg gaaatttata ggactagaaa
     2941 tctaaaaaag atgaaaatat gaattaactt aagataataa cgaaattatt aaaaagaaaa
     3001 ttcatatttt catcttttta tataagttct tgtgaaattg gacaaaacta ctcttttacc
     3061 ataatactaa atattatttg ttttacttcc ttttccaaaa gtattctccc aatcctctat
     3121 aaacttacct acactccaat cagttaatgg atgattcatc atagatttac aaatatcata
     3181 tggtactgta acactatgca ccccatgttg cattaattct ataacttgtt gtgcattttt
     3241 aaaactggct gcaagtactt ttgtatccat tttataagta tctattattt ttataagttc
     3301 tgaaaccata gctactccat caccagatat attatcaagc ctatttacat aaggtgcaat
     3361 ataatttgct ccagcctttg cagctaaaaa accttgatga gcagtgaata ttgcagtagc
     3421 agttattttt acaccttttc tgtgaaggtc ttttatagct cttaaaccat cttgtgttac
     3481 aggtattttt acatatatat tttttctcaa actacttata tataatgctt cttctaatat
     3541 ttcttcatac tttgtactta acacttgagc atgtataggc atatcctcac ctataatctc
     3601 accaatttca tttataagtt gcttaaaatt ctttttttct tttgaaacaa tacttggatt
     3661 tgtagttaca ccatctattg gtaaacaagt acataactcc ttaatctcct ccacattacc
     3721 tgtatctaag attagttgca ttaaaatatc cccctttaat ctttctttat tcttattata
     3781 tattgatttg gtattatttt caacattttg cttattgttt tttatttttt attattgttt
     3841 tacttttcct tcttagtttt ataatttttt tatttactaa attctaaata tatagttaga
     3901 aaaaacatac tttttatatt aaattaattt tgtatttcat gttaaaatag ttgatatatt
     3961 gtattttatc ttataatatt tactataata ctatattgcg aaaagaggta gaaaatgttt
     4021 gcagaagaaa gaatccaagc tatattaaat atcctaaaaa aagaaggtag agttactgtc
     4081 aaagagctca gttctaaatt taatgttaca gaagattgta taagaaaaga tttaaaaaat
     4141 atagaaaaga tttcttcaat aagaagaatt tatggaggag ctgtactagc tagagaaaca
     4201 ctagagaatc aggatacaaa agacagaaaa gaaattaata ttccaacaaa gaaaataata
     4261 gcagaaaaag catttaattt aattgaagat agagaaacta tatttttaga tatctctaca
     4321 attaacatct tgcttgcgaa gttgttagct gaaagtaata aaaaagtaac acttgttaca
     4381 aatatgctgg atatactaaa tgtagttact tcaaaaccaa ataatttaaa tataatttcc
     4441 actggaggtt tattaaatct cagtttagac ggttttgtcg gtactccaac tatagagttt
     4501 atatcgaaat ataagtttga taagactttt atgggaagtt gtggagtaga tgtattcaac
     4561 tcttcactta caacttttga aattgaagat ggtcttacga agaaggctat aataaattca
     4621 agtaaaaaag tatttatagt tatggaagat aaaaagttta aatttgatgg aaatttcaag
     4681 tttgctcatt tagaagatat tagttctata attacagaaa aaacgcctac tcctgatata
     4741 gtagatattt tatcagaatt taatgtaaat gttttataag tttaattata tgttttatag
     4801 gatttcttat aaatataaat ttttatttga taaatattct taaaaacata tttctataat
     4861 atttatttta tccttagtat ctatttttta aaatctagtt ctataacatc tactttatcc
     4921 ttatgtctat ttataaaact aatttgaaat agactttcta aatctaatac agttattttt
     4981 agaaagtcta tttccttaaa taaactattt aatattactg gctacttttt atatgaatac
     5041 aataatttgt tattcataaa taaaagctta tttcatttca ttcttcattt gcttctctaa
     5101 ttctttagaa aatttctttt gttcatatct ttccatcatc tcatcttttt tcatttctaa
     5161 gtttaccata gcaccttgtg catcatcttt caaatcttca gctgtatttt tcataacata
     5221 agctgtcttt ttaacacctt cttttaaatc ttctttcata tttttcatat ctctttttaa
     5281 tctatccatc aaaactacct cctctgtaaa tataatactt cctatattta tttttcccaa
     5341 agtacatata tttatttgta atatcaatta taatttttaa gtcttaaata tagtttaaac
     5401 tatctaaatc tatacatttc aataaattaa atatttttta tttcaaaata aaaataacac
     5461 taagcataga ttatatgctc ggtgttattt tttaaattca tagtaactta attgttgggt
     5521 tactataatg atgacttata tggaggatgt aaggaaatct catcattata gttggtgtat
     5581 tttatggttt taagcttatt tatatttata taatacagtt tcattatgaa ttttttgtga
     5641 ttttaaaatg aactattatt gaaagttata tattctttat aataagtaat taatttttaa
     5701 attctactgt gaatactaca gagttttctt tgttttttat gctataatca aacccatgac
     5761 ttttaaaaat ttggctgact atataaagtc caagtccact tcctccagtt tttctcgaac
     5821 gagatttttc tattctataa aatggattaa atatttcttc taaataacgt ttctcgatag
     5881 ttacaccagt attttcaatt tctaaaacca ctctttgatt agaagtcttt ttacttattc
     5941 gtttattttt atcatagagt ctaattataa gctctgattc ttcaggagaa tattttatgg
     6001 cattatttat tatattattg attgccttag ttattctctc ttggtctgct ttaatttcca
     6061 aattttcttc tatttttaaa atagttttca tatgtttttc ttctattaaa aatacttgtc
     6121 tctttacaag tctatttaat aattcactta tatttattga taccaatttc aaatcttttt
     6181 caagtatttc tgattttgaa acctctatca tttcatttac taaatctttt aattcttgtg
     6241 tacactcata cgattttttc agataagtat ccctatcctt atacttacct acactataaa
     6301 tcataccttc aatttgacca cttattatgg ttattggagt ttttagttca tgtgatattg
     6361 tagcaacaaa atccttcctt ctatattcct gttctctctc actctctatt atgtttataa
     6421 gaggctttgt tattacaatt gaatatatat atgctccaat aatcgctatc aatattgcta
     6481 ttgatatgat gtatggcatt agttttctta taacttcgtt tgcttcgtca attggttgta
     6541 atggcataac gagttctaaa gtatatggac catcttttgc atctttagta tatataggta
     6601 tagaagttct atactcatcc tcaagactat taatcatgta cttactatat cttaaaataa
     6661 ctacttcatt cttaccatat acaattttac cttggttatc ttttaataaa atagccaaat
     6721 tttggtcttt agccatataa taaagtcttt cttctaaagt atatgtatcg aaatgaattg
     6781 aactatctac taaagatttc aaactttctt gaagagactc aattttatac tcatgataat
     6841 atgatggcaa taaaaaatat aaaattagat atattattaa agctaatgct attaataatg
     6901 atgtcgttat tgaaaataac ttatacttta tacttaactt ttcccactta tcaaatatcc
     6961 ttctcaagtg tatatcctat tccttttaca gttttaatat atggtaatga tatttttttt
     7021 cttatatttt ttatatgtgc atcaacaatc ctagtatctc cataatagtc ataaccccat
     7081 atactatcca aaagaccttc cctagttata acttgtggat acttttctat caaagctttt
     7141 aatatattaa actcttttag tgtaagttct ataggttctc catctatctc tgcaatatat
     7201 gtgtttaaat ctaattttaa tttttcaaaa actataaatt tgtcatttat agtcttgtta
     7261 cttcgcctta aaattgcttc tactcttttt ataagaagat taaatgaaaa tggttttgtt
     7321 atataatcat cacattctaa gtcaaaccct ttaagttggt ctccttcatc atttaaagca
     7381 gttaaaaata taattggaac gcttgatgac tttcttatca ttttacaaac tccataacca
     7441 tctaagtttg gcatcattat atctaatatt actaaatcat aacttccttg cttaaacttt
     7501 tgtatacctt ccaacccatc atttgctgta tcaacttgat aaccttctgc acttaaaaat
     7561 tctgatatta actcttgtat atttgaatca tcttcaatta caagtattga cgaattcatt
     7621 ctatcaatcc tttctatttt atttaaaatt tcgtatatta cttatatttt atcttattgt
     7681 tgtgaatttt acatgaaaaa agagctatct taatttgtaa attaatcctt ttaatttaaa
     7741 gatagctctt ttggatacat tttatttaat ttattaatct aatctctctt atatgccttg
     7801 aagtttttaa gtctaagtgc atttgatacg actgaaactg aacttaagct cattgctgct
     7861 gctgcaatca ttgggtttaa taaaggtcct ccaaatacat ataatattcc tgctgctaca
     7921 ggtataccaa ttgtattata tccaaatgcc caaaataggt tttgttttat attttttata
     7981 gtttcatgac taagtttaat tgctgttgga acatcaatta aatcactctt cataagtact
     8041 atatccgcag attcaatggc tacatccgtt ccacttccta ttgctatccc tatatctgct
     8101 tttgcaagag ctggggcatc atttattcca tcccctacca ttgcaacaaa ctttccttga
     8161 ttttgtagtt tttcaacttc ttttgactta tcttctggta aaacctctgc caaaaccata
     8221 tctataccga cttgatttgc tatagcattt gcagttttcg cattatctcc agttaccatt
     8281 gcaactttta ttcccatatc atgaagtatt tctattgctt ttttactact ttctttgact
     8341 acatctgcaa ctgctattat acctgataaa tttccatcta cagctatata cataggtgtt
     8401 ttaccttggc ttgccaatat atttgatttt tcttctaaat ccccaagctt tatattattg
     8461 tcattcataa gctttctatt tccaagtaat atactttcat cattaatagt aacttgtata
     8521 ccagcacctg gtatggcttt aaaattatca actttttcaa attttatatt cttctcttct
     8581 ccatacttaa ctattgcttc tccaagagga tgttctgaac ctttttctgc acttgaagca
     8641 atcttgataa gatattcttc ttttacatta ttatttaata ctatatctgt tacttttggc
     8701 tttccttctg ttatagtacc tgttttatca aatatcactg tatttacttt atgtgcagat
     8761 tctaatgcct ctccaccttt tatcaagatt ccattttctg cgccctttcc agtcccaacc
     8821 attatagcag ttggtgttgc taatcctaat gcacaaggac aagcaattac aagtactgat
     8881 ataaatatag taagtacaaa tactatatct tttcctccta ttaaaaacca caataatgat
     8941 gcaactacag ctattgcaat tactattggt acaaaatatc cagatacagt atcggcaagt
     9001 ttagcaatag gtgcttttgt accttgtgca tcttcaacta actttattat ttgggcaaga
     9061 gcagtatctc caccaatttt ttcagcctta aacttaataa caccattttt attaatacta
     9121 gctcctgtca ccttacttcc aacattcttt tctactggta tactttcacc tgtaagcatt
     9181 gattcatcaa ctgatgtata tccttctatt acaactccat ccacaggtat tttagttcct
     9241 ggttttacta atagtatatc tcctatctct acttcttcta taggagtttc aacttcttta
     9301 ccatcaacta acactattgc agttttaggt tgtagcccca taagcttttt aattgcttct
     9361 gatgtttttc cttttgattt tgattctaaa tatttaccaa gtaagataag tgctattatt
     9421 attcctgcac tttcataata caactgatga tggtgcatac cttgaatttg tccattggct
     9481 atttgtagtg tcgtatatag actatataaa aatgcggcta atgttcctat tgcaactaaa
     9541 gaatccatat tagggcttaa agaaaaaagt gatttaaacc catttatata aaatttataa
     9601 ccagctatca ttactggtat tactaaaatt aactgaatta atgcataatt aaaagtattt
     9661 gtcataggat ttataatttc tggcaaaggc catggcccta taggctttat tatcataggt
     9721 cccattgcta tataaaacag aggtactgca aatactattg caactataaa tttaacaaat
     9781 aaagacttca tttctctttc ttttctcaat ttatcttcat ccacatcaac cttatttttt
     9841 acctcttcta ttggtttata tccagctttt tcaatagctg cttttatttg agataatttt
     9901 acttttgatg ggtcatagtc tatattagct ttatctgttg caatattcac actaatactt
     9961 tctactccat ccaatttttt taccactctc tctacagctt ttgcacaagc tgcacatgtc
    10021 attccatcaa ttttcatatc aattttttta ttactttctt cctttataat tccatatcct
    10081 gctttttcta caacctgctt tatatcatca aaattaacct tagaattatc atattctatt
    10141 ttaagttttt cagtagctat atttacactt tggtcatata ctccatccat cttcttagtt
    10201 actctctcta ctgcctttgc acaagctgca catgtcatac ctgtaatttt ataactttct
    10261 accactttat ttgaactcat aataaaatct tcctttcttt caatatattt tcagctaatt
    10321 tgtaacgttt tattttgata tgtaatattg ataaattact tatttagaaa tctatatttt
    10381 tattataccc cctataggta tattaaatca atattttttt aataaataaa tgtattagtt
    10441 atatttattt gtatttaata gaaaagtata ctcataatta aatgtatata taaaaataga
    10501 gcatctaaat tgtttaatgc ttatacaatt tagatgctct atttattata ttttatttaa
    10561 aatttattct ttacatgctt caaaaaactc tgcttctgtt tcctttattt caagctcatt
    10621 gtctattatt ccaacagctt cttttttaaa tgctctacac tgacctatac aaccagtctt
    10681 tacattttct tctccaacca aagtttttag cttatttaca tccacatttg aacagtttgg
    10741 acatactctt atcatattta agttcctcct aattaatgtc taattaatac ttttataccc
    10801 aaatataaac tttataaaag tttttttaat ataaattatt accatatata ccatttatat
    10861 cctattgcga gtattacata ttaattttat atattattaa tactacatgt acggtggtat
    10921 ctgttgtttt ctcactattt ccaattcctt aatttctaaa gacttaatca catttacttt
    10981 atagttttct ttagacttta tatacaaaac atcttctatc tttttacctt caataaattt
    11041 atgagaccac ttaagaagtt cttcaaaatt acaaacttct tcttttacaa aagtatcact
    11101 ttcacttgca aaatatttaa ttattatttt ggttacttcc aacatatatc atcctttact
    11161 cttttattaa tctttttatc tattaaggtt attatttgtc taaaaaattt ttttaaacaa
    11221 aataattttc agatgcaaaa ctaacagttt tattcaattt aaactatatt aatacaattt
    11281 aatatattcc tccttgtacc taataatata ttgtgctata attaataagt tattttaatc
    11341 gaagggagca acaaaaatgt cacaaaaaca taaaattata aatatcgcag ttatagccca
    11401 cgttgacgct ggaaaatcaa cattggttga tgctttcctt tctcaaagcg gtgtttttag
    11461 aaagaacgaa gtagttaaag actgcgttat ggacagtaac gaccttgaaa aagaaagagg
    11521 cataactata tattcaaaaa actgtgcaat aaactatgaa gattacaaaa taaacatagt
    11581 tgatactcca ggacacagtg acttttcttc tgaagttgaa cgtgttatga aaactgttga
    11641 cacagttatt ctattagttg atgctagtga aggcccaatg cctcaaacta gattcgtttt
    11701 acaaaaatct ttagagttcg gtttaaaacc aatattattt ataaacaaga ttgataaaaa
    11761 agaccagaga gcggaagaag tagttaatga agttttcgat ttatttgtag acttaaatgc
    11821 aacagatgag caatgcgaat ttcctataat atatggtatt gctaaacaag gtattgctaa
    11881 acttgaaatg gatgatgata gtgaagacct ttctcctcta tttaaaacta ttgtaaatca
    11941 cgttgaagct tatcctaatt acgataatga acctctacag ttccaaatat cagctcttgc
    12001 atatgatgat tatgtaggta gacttggtat aggtagaatt tacaaaggta ctcttaaaaa
    12061 caatacacaa gttgctatat gtagagaaga ttctgttgta tctaaaggaa aagtatcaaa
    12121 actttctgtg tatgaaggtt taaaacaagt tgaagttgat gaagctacta gtggagaaat
    12181 agttgttata gctggtattc ctgatatatc tataggtgaa actatatgcg atttagatag
    12241 tccactacct atggaaatga taaaaataga agagcctact ctttctatga acttcttagt
    12301 aaacgactct ccattcgttg gaaaaagtgg aaaattcgtt acaactagac atttgaaaga
    12361 tagacttgaa aaggaacttg aagtaaatgt tggtcttaaa gttgaacctc ttgatactac
    12421 tgatggatac aaagtttctg gacgtggaga gcttcactta tctatactac ttgaaaatat
    12481 gagacgtgaa ggttatgaag ttggtgtttc taaacctgaa gttttaatgc ataaagaaga
    12541 tggaaaatta atggaaccaa tagaaagagt tgttgtaaac tgtcctgaag tttactctgg
    12601 tactattata aatgaattaa acatgagaaa aggtatgatg gagtctatgt caatagaagg
    12661 agactatgta aaaatagagt tcttagcacc tactcgtggt cttttaggat atcgaagtga
    12721 atttataaac gctactcgtg gagaaggtac tttagttcgt tcatttgaaa aatttgaaga
    12781 atttaaagga gaaatacctt caagaggaaa tggtgtttta atagcacaag gacctggtgt
    12841 tactatgggg tattctctta atgccttaag tgatagagct gtaatgtttg tagaccctgg
    12901 tgtagaagtt tacgaaggta tgataattgg tatgaattcc agaaaagatg atatggtagt
    12961 caacccttgt aaaaacaaga aaatgagtaa cgtacgtgct tctggttcag atgatgctat
    13021 aaaattatct cctcctagaa tatttactct tgaagaagca ctagagttta tagaagatga
    13081 tgaattagtt gaaattacac ctgattctat aagacttaga aaaagattct taaatgaaca
    13141 tgatagatta agatataaca aatctagaca aggtaaataa aacgtacatt tacctctaat
    13201 taacaaaata gccatatagt actgaaaaat tatttcagtt tatatggcta tttttatttg
    13261 aaatttatat tattcaacat ttatataatt agctgcttga acggctgcaa tagctccatc
    13321 tgatgctgct gttattattt gacgtaaaaa cttagttcta ctatctcctg ctacatatac
    13381 accttctact gatgttatac aagactcatc tgaaattata tatccacctt catccaaatc
    13441 aagaacattt tcaaacattt tattattagg tttaagacct atagcaataa aaataccact
    13501 aacatctata gttctttttt cttcagtctt taagtttttt acttctattt tcgatacagt
    13561 cttttctcct tctatttttt ctacaccatg actgtaaagt atctcaatat tctctcttgc
    13621 tttcacagat ttctccaaca cttcttcacc tctaaaacta tctcttctgt gaattaaata
    13681 cacttttgta caattattag ctaaaaataa agcatcttct agtgcagtat ttcctccacc
    13741 tactatagca acttctttat ctttaaaaaa ggctccatca catgttgcac agtaagatac
    13801 tcctctacct gtaaattctt gttcccctgc acaacctaat ttacgtcttt caactccatt
    13861 tgcaagaata acagcctttg ctttatgttc acctgaagaa gtttttacaa cctttacttt
    13921 tccctctaaa tttatctctt caacctcatc aaactgaata tcaacacctt gagcaactgc
    13981 ttgattgtat atattattag aaaattctac cccagaaatc ttttgaactg ctggataatt
    14041 ttctacctca gaggtacttg caacttgacc tccataaata tttttttcaa atactgtaac
    14101 gcttaaccct gctctcatag cataaattgc tgaagttaaa cctgctggtc cagcaccaat
    14161 tacaatgata tctaccataa cgtttacctc tctttatatt attatttctt atatattatt
    14221 ctcatcattc ttatacttta ctattattat ccatatatac tataaacaaa acattatttt
    14281 ttattaatta actttatttt acatatatat aaaaaaactg caaataaaaa ttaactttta
    14341 tttacagttc tcacttattt atataattca aaaccttatt ggttatcatt tacagtgtct
    14401 tctaatatat tgctttctga tatatatgat agaattgaaa gtccatacat aaccaaaact
    14461 aatgctgctg ttataagtac tattcccata tttaatacct ccttttgttt acagtatact
    14521 attattatgt gaaatattta tgaatttaat ttgaatatat atgtaatttc acactaacaa
    14581 tttcttcaaa ttaaacatta ttaactatat acttttgttg aaccaattat gattaatagt
    14641 ttaaatatta gcactattta cttatattta tatgatatac catataatta catttttcaa
    14701 attaaagttt tgtaaacttt ttttgtaata tagtgtagta taaaattgta atattacaga
    14761 tatttaatag ttatctttta attactttca ttaaaaacag cttcatcact atgaaaatct
    14821 aggtttttaa acttttaaaa aggttaaaaa aatatttttc taatactcaa tttgattaca
    14881 atttttttac aatttaaaaa atattttttc caaattttta tattaatact tgactttgtc
    14941 tgttttataa actagaataa ttaataatat taagaatatt gaaaggcatt gattaggaag
    15001 agtaaatctg aatcgattac cagagaagga aactactagc tgaaatgttt ccctaattag
    15061 aaggattgaa aactacctag gagcttctat ccgaagttat cttaatgatt ttagtaggaa
    15121 tagacgtttt tattacttgc gttaaagtat caagtggatt ttttaaaatc aatttgggtg
    15181 gaaccgcggg aaacagattc tcgtcccttt tttagggatg agggtctttt tttattacct
    15241 aaattcagtt tttaaaatat tctgtatcta atttaattag ctaattaaaa atttaaaata
    15301 tatggaggat tataaaaaat gtattattca agtacgagag gcaccgaaga aaaagtaact
    15361 gcatcacaag caataataaa aggaatatca aatgatggtg gtctttatgt tccaagtgaa
    15421 tttcccaatg taaaaaatga acttataaat ttagtaaatt taacgtattc tcagatagca
    15481 ttttttgtac ttagtaaatt tttatgtgat tttactgaag atgaaattaa aaattgtata
    15541 gaaaatgcat atgatgaaaa gtttgattgt agtagtatag ctccattaaa taaagtaaat
    15601 gatacttatt tcttagaact atatcacggt ccaactttag catttaaaga tatggcactt
    15661 actataatgc ctcatcttct taaaacatct ataaagaaag ataatttaga gaaagatgtt
    15721 gtgattctta ctgctacatc tggagataca ggtaaagctg cacttgaggg atttaaagat
    15781 atagataaaa taaagataat tgtattcttc ccagaagatg gtgtaagccc agtacaaaaa
    15841 cttcaaatga aaactcaaac tggaaaaaat acatatgtag ttggtataaa aggaaatttt
    15901 gatgatgcac aatcaggtgt aaagaagatt ttttctgata aagaatttaa tcaaaaacta
    15961 ttggataata attatatatt atcttctgca aattcaatta atataggaag acttcttcca
    16021 caagttgcat actattttta ttcatatatg aaattagtta gcaatagtga tataaattta
    16081 aatgataaaa taaattttgt tgtcccaact ggtaattttg gtaatattct agctggatat
    16141 tatgctaaac aaatgggtct tccaataaac aaattaatat gtgcatcaaa tgataataat
    16201 gttctttatg atttctttaa aactggtgta tatgataaaa atagaacatt gaaattaact
    16261 acttctcctt ctatggatat attaatttca agtaatttag aacgattact gtttgaaata
    16321 tcaaatagaa atactgatat tgtaaataag cttttatcag accttagtga taaaggagtc
    16381 tacaaaataa gtgatgatat ggaaaaaaat ttagcctcat tctatggaga atattcaaat
    16441 gaagaagaag ttaaaagcac gataaacaat gtgtttaaaa attataatta tttgatagat
    16501 actcatactg ctgttgcata caattgttat gaaaaatata aaaaagaaac ttctgataac
    16561 acaaaaactg ttattgtaag tactgcaagt ccattcaagt tttctgaaga tgttctaaag
    16621 tctatagatt gtgattttaa agaccttgat gactttgcta taattgatag attatcaagt
    16681 atttctaaaa tagatattcc aaaacctatt aaaaatctta aaaatgcaga aatactacat
    16741 aaagatattt atgaaaaaga tgaattaaaa ctagctataa aaaaattctt aaaggtatag
    16801 gtgattatta tgttagagat tatagttcct gcaacaagtg ctaatatagg tccaggattt
    16861 gattgtcttg gaattgcgtt aaatatatac aataaatttt atgttgaaga aattgaaagt
    16921 ggtcttgaaa tagaaggttg tgaagatgct tacaaaaacg aaaacaactt agtttataca
    16981 tctatgaagt acttttttga tagagttaaa ccagaaaaaa tacctgctgg tatcaaaata
    17041 aaaatccaaa gtgaagtacc tatatgtaga ggtcttggca gtagtgcctc ttgtatagta
    17101 gctggagtta tagctgcaaa tgctctatca ggtgctaatt tagataaaaa tcaattacta
    17161 aatatagctt cagaaataga aggtcaccca gataatgttg ctcctgctat tttaggaaat
    17221 atgattgtat ctgttactga taatgagaat atacattatg atattataaa aattcctgaa
    17281 gaacttaaat tttgtgcaat gatacctaat tttaagttat caacagaaaa agctagaggt
    17341 gttttaccaa aggaaatacc atattctgat ggggtattca atgttagtag agttgcttta
    17401 ctaatatctg ccttactaaa caaaaacttt gacctactta aagtagcttg tcaagacaaa
    17461 ttgcatcaag attatagagg aactctaatt gagaactaca atgatattgt tgaaaaatct
    17521 gaacaattaa atagtattgg agtattttta agtggagctg gacctactat aatgtcttta
    17581 ataaaagaaa atgatgatag ttttgtggat aatatgaaaa attacctaca aaaactaaaa
    17641 tctgattggg aaataaaaga gttatgttgc gattctaatg gagctgtttt aaatataata
    17701 taattatcgt cttctataca aaatataact actcttttat tataatttgt agtataataa
    17761 ttaggactag gtaataatat taagtattat aatctagttc tttaaacatg tttacattga
    17821 ggagggatta tcataaaaga gttaataatt agagatttag ttgcaaaagt tcctataatt
    17881 caaggtggaa tgggcgttgg tatatctagg tcatcactag ctggtgcagt tgctaagctt
    17941 ggtggtgttg gtgtaatttc tggagttcaa attggatatg atgaggaaga ttttgaaact
    18001 aatactataa atgcaaattt aagagctata aaaaaacata tttctaaggc caaagaaatc
    18061 tcaaatggtg gtattattgg tattaatttt atggtagcta tgaaagaata tgaaacatac
    18121 gtaaaggaag ctgttaaagc tggtgtagac cttataatat ctggagctgg attacctaat
    18181 aagctaccat cattagtaaa gggaagtaat gtaaaaatag cacccatagt ttcaactgca
    18241 aaagctgcta atgtaatttt aaaaatgtgg gatagaaaag agaaaactac tgctgactta
    18301 atagttgttg aaggtccaaa agctggtggt caccttggat actctaacga ggaacttgat
    18361 aacatagatt ctatagacta tgataaggaa tttgttgaaa ttttaaaggt tgcaaatact
    18421 tatggagaaa aatttggtag aaacatacca gtagttgctg ctggtggtat aacttctagt
    18481 agtgatgtta aaaaatatat agatatgggt gcaagtggtg tacaagttgg tacaagattt
    18541 gttgctactt acgaatgtga tgcccatgag aactttaaaa tggcatacat aaatgctagt
    18601 gaagaagatg ttcatatagt taaaagtcct gtaggtcttc ctggacgcgc cataagaaac
    18661 aaatttatag aagaagttaa aataaatcgt ccagaaataa agaagtgcta taattgtttg
    18721 attccttgta atccaaaaga aactccttac tgtatttctc aagctctaat caatgcagtt
    18781 aaaggagatg ttgaaaattc acttttattt tgtggaaatg atgcctataa aattgataaa
    18841 ttaagtactg ttgaagatgt tatcaatgaa ttgatttctg aattataatt taaagaaaac
    18901 taaattaaaa ttttatcaag ctaaggagtt taaatacgtt atttattaat ctttataaac
    18961 atatttatgt ccttagcttt tttgtgtcaa tttcctttta tggaaatttt aatttaatta
    19021 gagatagtat taacctttat aactaatctt cttttacaag tacattggtt atttcagcta
    19081 tatataaagt atgataatct ttttgtggat accatcttcc atctatacct tcagcaataa
    19141 aacattgagg ttcaagtttc tgactataca tttttttgca tataatagcc attttagatt
    19201 ctttaaaata aggtgtatca tttaagtgtt ctatattaaa tccaatctgt gatatcttat
    19261 cctcttctct accagatacc tttccacaat atgaaagctc tttacgaaaa tcttcatcaa
    19321 aaaatgtaag agaaaattta tctgtattat ctataaattc cttagtataa cgctgtggtc
    19381 ttattactac aaaagcaaca tcttttcccc acataactcc aagccctccc cagctagcag
    19441 tcattgtatt cactttacct tcattttctg ctgttataag tgtccaatct ttacctatca
    19501 atccaaatgg attattttta atctcttctg ccaaaatctc tttaaaatca ctcatatctc
    19561 taataacctc tcattctctt atatttatat tccttttatt ttcgtgataa attataaatg
    19621 aagtctagtt ttgaaaataa aatacttttt taaatatatt attgcaaata agtaaatata
    19681 tatatactct cttatttttt aatatattta ataatttcac tcagaatata tatattcttt
    19741 actcaaatta aatataactt atatacttta tgtgtaaatt atggtaaaaa tattatttaa
    19801 tcaaatcaaa acttgattta tatacctgga aaaggtatta tattaaagag tgcttaaaat
    19861 acgcatttca taaatagcta tatataaaat aataaataag gagagtgatg ggcaatggat
    19921 actagtccgt tgcggagaga attttttaca ttttcatcac ttaataatat ctaaaatcaa
    19981 aactaataca tatattcagt tatataaatt agttaattaa tagatactat taaatgatga
    20041 gatttatata aaactgaata aaggatgtgt tgccatgata agatattaca aaactataga
    20101 ttcaaaatta gagaaactta gtttttttga agatggctgt tggataaatc ttgttgaacc
    20161 taatcatagt gaaatcaacg aaatttctaa tttattaaat atagatgtag aaagcataga
    20221 atctgcacta gatgaagaag aacgctcaag aatagatgtt gaagacaatc atactcttat
    20281 acttatagat ataccagtag acgaaagtga ctctaattct tctcattata ctacaatacc
    20341 cttaggtatt atactaactg aagaagctat tgtaacagtt tgtgatgcac aaactaagat
    20401 tttaaatgac tttatagttg gtcatattaa agattttttt acgtttaaaa agactcgctt
    20461 tttgcttcaa attcttcaca aaaatgcagc ttattacttg cattacttaa gaaaaataaa
    20521 taaaatgaca atcataatag agcgagaaat ttacaaatca atgaaaaaca aagaattggt
    20581 tcaattattg gaattagaaa aatctttggt atacttctct acctcactaa aatctaatga
    20641 acttgtttta aacaaaatgg ttagaactgc tggtataaag aagtatccag atgatgaaga
    20701 cctattagaa gatgttatag ttgaaaatag acaggctctt gatatggcta aaatatatgg
    20761 agatatattg agtagaatta tggatgcttt cagtgcaatt ataagtaata atcagaataa
    20821 tgttatgcaa attttaacag tagttacact aattttctca atacctacaa taatatcagg
    20881 attctttggt atgaatgtca tcaacatgcc attttctaat aacccaaacg gattttggat
    20941 aatacttctt attacctcta taatatgtat agtgattaca tttttcatgt caagaaataa
    21001 gctattataa aatattaata aaaaggccat tagaattaat tgatttacat ttatcctaat
    21061 ggcttttata tatttaaatc tatataatct tataatactt tttaactatc atgttcttca
    21121 tctataatca tttcagtttc aagcccttct agcattgaat ctaaactttc ttttatattt
    21181 agtatataaa ttggtacata ctcttcttca tctattacct cttcttgcaa cttaaatgga
    21241 ggaattaata cttcatcaaa gtctatattt aaatttggaa agccttctac tatctcttca
    21301 caattatcgt actcttcatt tgctaaagaa atgtacatat ctaggctctt tttataataa
    21361 agacctgcaa gcatatactc acacttctta cttccatatt taataccttc tttataatat
    21421 ttctcagctt ctgcgtcatc atttaatttt aaataaattt gacctaaatt atatattgat
    21481 tcaacacaac cttgtgctct agccttttca taccaaaatt tagaatttac ataatcttta
    21541 tagaacatat cataaattaa tcctaccata tgttgagcat acacattatt ttcattggca
    21601 ggtgtatcaa acatcatttt agactcttcc aatttacctt ctctaaaata aattctacct
    21661 agatgtatac gagcattcat atggtttttg ctacttgcca tttcaaaata ctttctagca
    21721 ttttttgtat ttcctaagct ctcatatata caccccaatc tataactaga cctcgtatct
    21781 ccattttcag atgctttctt ataccaactt attgcttctt caatattatt taaatcttca
    21841 tagatatttc ctaatttgat ttgacaagat acattatttg gaatcctcga ataatacgaa
    21901 atcgcttttt ctatatcttg attctgataa tataaatccc ctagattttc aagggaactt
    21961 ttgcatccaa cagctatagc atcctcataa tatttaatag cattttcata atctttttct
    22021 tcaaaatata tacctgccag attatttttt gcttctgtta tatcatcttc agcagccatt
    22081 ttataataag tttttgcctt ctctatctca ttttctctat tatataaatt agcaagtcta
    22141 tacttagaaa gtatatgatt tttttctatt gctttctcat aataataaat tgcatctccc
    22201 agctcttctt ttctatcata tacatatgca agcctatact cagacttcac atcatctcta
    22261 tcagcactct ttttataata cttctctgca tcttctaaat tatcatttat ttccataatc
    22321 atacccaagt taaagcaacc tttcatatga cctgacttgt acaactgttt atataaactt
    22381 actgttgatt tattatcttt cttttttcca tttaatattg ctaaattata ttttgcatca
    22441 tcatctaaaa gcacagaacc ttttttatag tattcatatg cttcatcatc tttctccaaa
    22501 aaagtatata atacccctaa attaaaacaa gctttaccta aattcttgtc tgctgctgtt
    22561 tttaaccatt tttcacacct tacaaaatct ttcattttaa aatggcatac acctaaatta
    22621 ttttgtgctt gtaaataacc taaatttgct atcttttcat accaatatat agcatattca
    22681 tagccatcta acttatagta catattacct aaatcaaaag cagcatcttc acttccactt
    22741 ttatatgcca tcgaatacca cttttctgct tctttaaatt gttttttact ttcatatata
    22801 tttcctaaag tatattgaga ttttacgtaa ttatccaatg cagcactctt atacaactct
    22861 attgcgcttt ccatcttacc catcttttca aggagggcac ccttagtatg tacgactttc
    22921 gggtcattag atatattttt tatttttttt atagaaaatt ttgtattttt cattattcgc
    22981 tacctaccca ttttataaaa tatattctct caaacattat tatacattat aatctacaat
    23041 taatgctata atattgaatt tttacctttt gtcactatat tgtaacatta aattttaaat
    23101 tttataatca ttagatttta ttatgtaatt ggtatataat gtatatatag gggggacatt
    23161 ttatgaattt cagcaatatt tttatccaag ttgcagtttt atttataatt attttagttg
    23221 gatattttgt cagaaaattc aacttattag atgaccactg cacatctaag ctttcaactt
    23281 tgacaatgac agttttttta ccatcaatga taattagctc catgcaaatt aactttgata
    23341 gtaaaatgat acaaaaaata ctattgttat tatttacatc tttgattatg tatatagttt
    23401 caattataat tgcattttta ttgaaataca ttttaaaatg taatgataaa aaagatttgg
    23461 gaatatacca gtatatagtt gttttttcaa atgttgcttt tatgggttat cctgtaattg
    23521 aagcagtttt aggtcatgaa gcaatattct atactgcaat attcaatttg ccttttaact
    23581 tattttcttt cactttagga atttatcttt tatctaaagg cagtacaagt agaggttttt
    23641 caataaaatc acttataagc cctgctacaa tagctattgt tattggactt tttttatttg
    23701 taacaggact taggttaccc caatttataa acgagccact tgagatgttg ggaagtataa
    23761 ctacaccaat atccatgatt atcattggaa gcttacttgc taattcttca gctctcgatt
    23821 gttttgtcaa caaaaaatta tatatagtca cttttataag attattggta cttcctgtga
    23881 ttgtgtattt tattctaaaa ggatggataa atgataagat gattttagct ataccagtag
    23941 taatttcttc aatgcctgct gctgcaaata ctgctataat ggctaatcaa tatgactcca
    24001 atataacact agcttcacaa tgtgtgtttt ttacaacact attttcagtt atatctatac
    24061 cttttataag tattttactc ttatcttgat ttattttttt atgtattata taataacata
    24121 ttcaataaat tacaaatata aacattttat tgtagtatat tgatggaatt ttttcctaga
    24181 tatttgtcaa taatatctat atgtattata gaataggagg cttaaatatg gatatggatt
    24241 tactctttaa aatagtattt gctatagttg ctataggtgt ttctgtaaaa atcattaaaa
    24301 ctgttgctag tttagctttt aaaatagcgt tgatattgct aataatttta tttgtatata
    24361 gaatgttttt gtaaacattt aaaaataagt tttttaacac aatagagaag taaaatagat
    24421 tatctttaat gtaaattttt tattaaagac actctatttt acttctctat tagcttcttt
    24481 aaattaaatt tttattatat cttcccataa tataaacatc ttcaaatttt ccatctctga
    24541 ttacagcata ttttttagtt ccctctattt caaaacctag ctttttatat aaatttaatc
    24601 ccttttcatt atccacaatt acttctaatc ctactctagt taacataatc caattatctg
    24661 ctatatctaa aagttgttcc ataagcttct tacctactcc tcttccctga taattctctg
    24721 caacacttat tcctatttct gcgctatgtc tcaatcgtgg agaagaattt acatgtaacc
    24781 cagcaaaacc tattacatct ttttctccat tattattagt ttcagctaca aacatataat
    24841 cattttctcc caaagaagct aacatagctt cagttttatc gactctgtca ctcattaatg
    24901 ccaaagtatt tctcataaca ctgtatgttc ttctaatttc attaaaagct tgtgcatctt
    24961 ctcttcttat aggtcttatt gttatatcta taggcttact catattggat tccccctcaa
    25021 acataatctt tatttttaat taaaatttta catctttatt ttatactgtt caaatctatg
    25081 tatgcttcta cctgaggtac atatatcata ttatctttta tatgtgtact tccaaattct
    25141 tttaattctg taccttcttt atccttagtt attttatatc taatggattc cataccttca
    25201 actacttcag catgaaaaaa cataccttca tattgtttaa atctaaaatt aaaattgtct
    25261 ttagtaagtt ttattatcat atttttatct actccttata taattgatat ttttcttatt
    25321 attagttgta tatatactgc ttattcatat taatatatta taacttatca tttatttagt
    25381 ataaagttat aaatagatat atttatactt attttacaat ctttcttcaa ttgatatata
    25441 atatgtttat ataaactaat gtatgtgagg tgaaatatga gcaaaaaaac aaaatatttt
    25501 tctttaattc tctttcctat tgctttgctt ttaaatttta tagccagtaa agttccaaat
    25561 attgttgaaa aatattactc ccaattcata gataaaataa ttgtacaaat attgagtaaa
    25621 gtttctggaa ttttcccatt ttctctctat gagattacaa tgtacataat agttatatct
    25681 accttcttat ttttatgttg tactttatct acaattttta ataagaaaaa aaaattaaac
    25741 atatatttaa aaaattccat tttaaatata ttatccattg tatcaatagt ctactttctt
    25801 tttgtagtgc tttggggaat aaactataat aggattccac tagaaaccac acttataaat
    25861 aactataatt taaaaaacaa tacctctatc caatcaaaac aatatagtgt taaagagctt
    25921 actaaattat ataaattcct tgtaattaaa gcaaatgaaa ctagaaaact cacattacaa
    25981 gataaaaatg gtattgtaaa atctaataca gattataatg gtgtcataaa tagagctcaa
    26041 ctaggatacg ataatatctt ggatatatta cctggtgtta gtgatagtta ttctaagcct
    26101 aagtatatta tttcatcaaa tctaatgtgc tatacaggaa taactggtat atactttcct
    26161 tttacaggtg aggcaaatgt aaatatagca atacctgact tatatattcc ttgtacagtt
    26221 gaacatgaaa tggcacatca aaggggattt gctagtgaag atgaagctaa ttttatagcg
    26281 tatcttactt ctataaaaca ccccaatatt gattttaact attctggata tattttagct
    26341 ttaaattata ctgcttctgc tttaagtaag gttgattata atgcatatgt tgatatttct
    26401 gctggcattt cagattctgt ccgtagagat ttaaaaaatg aaagtgaatt ttggcaaaaa
    26461 tatgaaggta aaattaatga aatttctaat gagtttaaca attcttactt aaaagctaat
    26521 ggcgttactg aaggtactca gagttatggt aaaatggttg atttattgct aacttattat
    26581 gaattatatc catataacta aacactacaa ttcaaaattt tattcatata cagctgatat
    26641 taaatcagct gttttctatt taaataaatt atttaacttc aagcaatctt atataatttg
    26701 atagtactta tactatctgt ataacatttc aattctaact attttagtta aaacatttct
    26761 attatctttt ttaataaatg ttttaactaa aatttttaaa acataaaact tccacattat
    26821 ttcactatct atataaaaat ctaaaaattc acatataaaa ttacataact aaaaaatcat
    26881 aaatttatag aaaacatata ttcaaaataa aaaagcatgt atcaaaactt gacacatgct
    26941 tataatctta tgtatatata tcattttgtc acaataaaaa tttacttgta acactgatat
    27001 ttttaaacaa aatagtcctt atttaattaa attaacatta attaaattcg tactcatttt
    27061 gctatcatta aacattactt atagtaattt tctaatacac tatttgaaac ttccttccct
    27121 tgaaaacttt tcaaccaatt ctcatatgct gagtttttcc atacactacc atcattaaat
    27181 gttacttgtt ttacacaaga tataatgtac tttacaccat gctctccagt tgattgtttc
    27241 catttatcaa acaatagaaa ggcatcattt tgattcttac ctggtgctat tgcattttgc
    27301 tttgcatatt ctttctccat ttgtttccat tctttcaacc aattttctac ccatgccttg
    27361 ccttgttgtt tttcaaacat acttattata tcctgtggtg gtgattgttg catttttcta
    27421 taagtatgtg aatatgattt tggagacaca ggagatatgc ctgtaacaat accatagtct
    27481 acaccagctg ggctaaatcc aacacttcct acttcgccat ctgctgccac attttgagca
    27541 tcccaatata gctcaagtgg ttttccattt ttatcatatg ctaagcatgt aatttcataa
    27601 tccataattg ccttttcact gctatttgtt aagcttataa cattgctagg ccaatgatat
    27661 ggagtatcat catactgtat tttgctatta tttataaata atggaatatt ctcattataa
    27721 acaagacctt tactactttg aatatctgat accttctttg tgacagtact taccgtattt
    27781 gctaagtata catttgtttt ttctgaattg gtcgtactaa gagaaaatgt tgttgtcgtt
    27841 ccagtaatca gcaaagcaac aactaaaata ggtaagctag atattttttt atatctcaca
    27901 attcttcacc tctttttcta ttaacttata ataaaacaat ttaccaaaac attaaaatct
    27961 atgttaacat aatttaccaa ctgttctagt aactatatcc tatcatagtt actatcaagt
    28021 ttcaatacta ttgatggaaa ttttcactat attaaatctt tttttaattt tataaattta
    28081 caatatgatt taactcatac atatatagtc aaattagaat ataagtttct tacatttaat
    28141 gaagtttata aaataaaaaa tgactagata attaaatact gtaaataaaa acttattaca
    28201 aaagtattta aaaatctagt catttaatat atatatgaat tgtatactat aatttttcaa
    28261 tctcttctag caactcatca actaatttgt taccatcaat cattctaact atttcaccct
    28321 ttttaaataa aagaccttca cctttacccc cagcaatacc tatatctgct tctctggctt
    28381 caccaggtcc atttacagca cagcccataa ttgcaacagt gatatttttt tccatactac
    28441 caatcttttc ttcaacctca tttacaacac taattaagtc tatattacat ctaccacatg
    28501 tagggcatga tataacttta atcttatcat ttaaaagtcc caaacttctt aaaatctgtt
    28561 taccaacaat aacctcttca acagggtcgc ctgttaaaga tattctaaca gtatctccaa
    28621 ttcctttaag aagaagtgct cctaccccta tagaagactt tattgttcct ttgtgaacac
    28681 ttccagattc tgtaattcca atatgaagag gataatcaac tttttttgat attaattcat
    28741 atgcatcaac agttttataa atatcggatg attttagaga tataactata ttatgaaaat
    28801 ctaagtcttc aagaatctta atatgtccca ttgcactttc aactaatgct tcagcagttg
    28861 cagagccata cttttttaaa agttctttct ctaaagaacc tccattaact ccaattctaa
    28921 tttttaaatt tctttccttg catttctcaa ctaccatctt aactctctct atacttccaa
    28981 tattaccagg atttattctt attccatcca caccttgttc tatagcttca agggctagct
    29041 tataatcgaa atgtatatct gcaataattg gtatatttac actagacttt atctttgcta
    29101 tatttttagc agctttaata tcaggaacag caactctaac tatatcacaa ccagcttcct
    29161 ctaatctctt tatttgagct attgtagcat ctgcatctct tgtatcagta tttgtcatag
    29221 attgtatact tataggattt tctcctccta tttttacagc tcctacactt acttctctcg
    29281 tctttcttct ctcgtaactc atattccacc tctatatatt attttatatt gaatctcttt
    29341 aaatattaaa atattataac ctacatgtat attataaatt aaaaagctat ctagttaaat
    29401 aagaataaat ttcatatata aaaattaatt tattcttatt taaaactaca tagcctattt
    29461 tcttaaaatc tctaaaaaac taaatcattg aaataatctt agtatatctt tatatgtgat
    29521 aaaaagcata aataacatta aagctccaaa accaacaaca tttatcatgc cttctttatt
    29581 tgggtcgagt tttttaccac ctctaacagc ttctagtaac aacataagta ttctccatcc
    29641 atcaagtgct ggtattggta atagatttac tatacctaaa tttaagctta tgacagctgc
    29701 taaatacact acatttatga tgcctgtacg agcagcatct gataccatac caataacacc
    29761 tactggtcct gctacagcat tgccaatccc tcctggtaca cgtcctgtaa tcatttgacc
    29821 tagaaatgtt agcatctgtt ttgtcatatc tacagtagtt ttacatgcat ttactattga
    29881 ccctaaaaag tctttttctc tttgtggttg aattcctatt tcatactttc cattgttatt
    29941 tttaggtgtt acatttacaa ctttatcact tccatctcta gttatactaa gttttaattc
    30001 tccaccagaa gaagtgttta ttatatttgc aacttcatcc caagtcttaa cagaattacc
    30061 attaatttta tttatcttat ctcctacttg aagccctaca gcctgtgcag gagtatctgg
    30121 cattatcttt cctaatttag tcgttggaga acctatatac aaaaatactg gaactaaaag
    30181 tattgctgct aatattatat tgaatattgg tcctgctaca atagtactaa atctttgtaa
    30241 tatagacttg tttccaaaag aatttggact tatttgttct tcatcttcac cttccatgct
    30301 gacatatcca ccaattggaa gtgctcttat agaatactct gtatcttttt ttacactata
    30361 tatcttaggc cccataccta tagaaaactc atttactttg ataccacttc tttttgcaaa
    30421 tataaaatgt cctaactcat gtattaatac aattatacta aatagtatta atgcggctat
    30481 tatagtcata aattcacctt cctatttttt tatcagattt gcaacataag ctctactcca
    30541 tctatctgtt tctaagattt cttctaatgt tggttcactt atgctactat gaacttctaa
    30601 agtcttctct atgtaatatg gtatgtcata gaaaccaatt ttatcctcta aaaattcact
    30661 tactaaaact tcatttgctg aatttaaaac agaagaataa gttcctccca tttttaaaca
    30721 ctcatatgcc aattttaaac atggaaaagt ttctaaatct ggttcttcaa aagttaaagt
    30781 actaaatttt gaaaaattca ttctttcaaa gctactttcc attctatctg gatatgtaag
    30841 agcatactgt attggtagtc tcatatctgg acatcctaat tgagcaatta ttgagctatc
    30901 tgtatactgc accattgaat gaattatgct ttgtgggtga actactacat ctatattttc
    30961 ttgttctact ccaaataacc atctagcttc tatcacttca agtcctttat tcataagcgt
    31021 tgaagaatca atacttattt ttcttcccat actccaattt ggatgcttca aagcttcatt
    31081 tttagttata tttgcaagtt ctcccttttt ctttcctcta aatggaccac cagatgctgt
    31141 aagtattatc ttttctatat tttttttatt ttctccattt agacattgaa atatagcact
    31201 atgttcacta tcaacaggaa gaatatttac attgtatttt tctgcttctt tcattacaag
    31261 ttcaccagca gttaccaacg tttctttatt cgctaatgct atgtctattc ccttctttat
    31321 agcacaaaga gttgggacta atcctatcat acctactaca gcagttaaaa ggacatccac
    31381 ttcatcaagt gatgatatta tttttaatcc ttccattcct gctaaaactt ctatttctat
    31441 atttttaggc aacatttctt ttaattttaa tgctttattt tcctcaaaaa ctgttacata
    31501 tttaggttta aactctacta tctgttctag caataattca atattactgt tagctgatat
    31561 tgcaactatc tcaaacttat ctctatgttc tctaaccaca tccaaagttt gtttacctat
    31621 agagcctgta gaacctaaaa ttgatatctt tttcatataa taatcctttc taataataaa
    31681 tataccctgt caaaacatta taacactact aaaacaatta tttttactat tcatagaaat
    31741 ttcatatatt attccacaga ttaaaattaa tctattattt tttgtatttt gtggaatatt
    31801 ataaaatatt ctagtattat taaatgccct tttttatttc cacaacatct tctattttac
    31861 agtctagtgc taaacatatc ttctccattg tatccataga aacagattta tcatttccta
    31921 gtctgcctaa aacagaaata cttatacctg atatatttac aaattccatt ttctttattt
    31981 ttctgtcaat taacaatttc cataatggag cgtatgaaat catgttatca cctcgcaaaa
    32041 tatattctat cacattttat ctattttgga aaattttcat ctatttagat aaataatcac
    32101 ctgcttaagt gtcaaataat tttatccttc taatatgaaa atttaatact atactaaatg
    32161 attggtatat aacacatatg atgcattatt attaacatat aaaaattttt attggtgcta
    32221 aattaaagta atatactatt attatatttg cagatatata agaa
//
LOCUS       DAEHWM010000038        32040 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.039, whole genome shotgun sequence.
ACCESSION   DAEHWM010000038 DAEHWM010000000
VERSION     DAEHWM010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 32040)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32040)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32040
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.039"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            195..545
                     /locus_tag="KNP36_001865"
     CDS             195..545
                     /locus_tag="KNP36_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HBF0873739.1"
                     /translation="MSAKVTNQYGNIEIDNQVIAQVVYRAAMESYGLVGLAYKSKGIV
                     ELLKGENATKGVRVEEVEEDAIAIELYVIIQYGTNISTVANNIIDRVKYVVEKMTGVR
                     VTRIDINVQGIRVK"
     gene            564..2207
                     /locus_tag="KNP36_001866"
     CDS             564..2207
                     /locus_tag="KNP36_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HBF0873740.1"
                     /translation="MIQYIDGKRLREMFISGANNLQNNKELVDKLNVFPVPDGDTGTN
                     MSLTISYALKELAKVENDNISDIGKALSKGSLMGARGNSGVILSQIIRGIAKSIEGKS
                     KLSTEDLAKAFKNGSDTAYKAVIKPIEGTILTVVRESGEFAIKTAKKEKDVVKFLSML
                     VKESNSSLERTPDLLKNLKEAGVVDSGGKGLVLIYEGMLASIKGDNIEIKNVDLDTNI
                     STSMDFAKSTTSTDDIKYCYCTEFILESSKVEDTKIRDIMMAYGDSLAVVGDDGVIKV
                     HVHTNDPGNVLQEALKYGQLLTIKIENMKLQHENTLLDVEEKKENDSEPLEEEKEFGF
                     IATSMGEGLANIFKDFGVDHIIEGGQTMNPSTEDFMNAIKHINAKNIFIFPNNSNIIM
                     AANQAKELSDKNIIVIPTKNTPQGFAALVTFNGELSEDENKEAMMNALNSVKSGQVTF
                     AVRDTVMNEIDVKEGNIIGIAEGNLLSAGDYVDEVTSNLIEKLVDEDTAIITLFFGED
                     VTESQANELRTSLEEKFEDVDVELYYGGQPLYYYLISVE"
     gene            2288..4345
                     /gene="recG"
                     /locus_tag="KNP36_001867"
     CDS             2288..4345
                     /gene="recG"
                     /locus_tag="KNP36_001867"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HBF0873741.1"
                     /translation="MDLYKDVQYVKGIGPKKADKLNKLGIFTLKDLLYYFPRQFEDRN
                     NLKKIAQLEDGEKVTIKAVISSINTFSPKEGMTLTKIDVKDETGSAKLVFFNKSYIKN
                     TFRPGDSILVFGKVKKKFNNLELTSCELEYLTNSPKNTCRFMPVYQLTYGVTNKEIMS
                     IIRTVLEDKELIIQEYMPQRIIEKYRLCSIDFAVRNIHSPSSKESLKIALYRIVFEEL
                     LILQLGLFVFKSGRNKEDGIKFETSKDLKKIISALPFKLTKAQNRALDEIIQDMNLEK
                     IMNRLVQGDVGSGKTVVALLALANCVLNGYQGALMAPTEILAGQHYISLTESLKDFGI
                     NVGLLIGSLTKKQKDTVLEQIKNNEIDILIGTHALIEDKVEFNNIGLVITDEQHRFGV
                     MQRSKLSLKGANPDILVMTATPIPRTLALILYGDLDISIIDELPPGRQPIETIAIEKS
                     KRDRAYNNLVRREVESGRQVYIVCPLVEESEAIEAKSAVELVEELRAEYFHDLRLGLL
                     HGKMKSSEKDEVMRLFKDKEIDILVSTTVIEVGVNVPNATLMIIENAERFGLAQLHQL
                     RGRVGRGSHKSYCVLIYDSKTDVCRQRMAIMEETNDGFKISEKDLEIRGPGEFFGTRQ
                     HGLPELKVANLFKHIKILKLAQQEARYILGEDNNLQLKENMALKKEIIDKFKDTLKEI
                     SLN"
     gene            4404..4958
                     /gene="rsmD"
                     /locus_tag="KNP36_001868"
     CDS             4404..4958
                     /gene="rsmD"
                     /locus_tag="KNP36_001868"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HBF0873742.1"
                     /translation="MRVISGKARGLKLNTPKNEDVRPTTDRVKESLFNMINSYIMESE
                     VLDLFAGTGSLGIECLSRGAKSCTFVDISKESIDIVKSNIKKARVESESIILNLDFKT
                     AIDKLKLQNSKFDIIFMDPPYYKNMFIEAIEKIDNSNLLNEDGIIVVEHDTNDLFPDK
                     ICKLEKTRDKKYGNTTLTFYKMEA"
     gene            4960..5457
                     /gene="coaD"
                     /locus_tag="KNP36_001869"
     CDS             4960..5457
                     /gene="coaD"
                     /locus_tag="KNP36_001869"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HBF0873743.1"
                     /translation="MENKPRKAIFAGSFDPITNGHLDIICRASKLFDELQIGVLNNPN
                     KKGLFSFDERVKLIEKSTSHLNNIKVVTFDGLLINYCQENGIGALVRGVRSGADVDYE
                     LQMAHMNRELNPDIETIILPSCTKYSFISSSLIKEVLLFDADIKNLVPKIVLEELKKK
                     TSGGN"
     gene            5461..5985
                     /locus_tag="KNP36_001870"
     CDS             5461..5985
                     /locus_tag="KNP36_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873744.1"
                     /translation="MKIDLEMIELFEQLEEIFRSASTIPFSHKCTVDKDEVLAIINDI
                     RTLIPEEVTQAVWINKERNKIISQAKQDATNIVEQAKKEAERIQQEYQDNIEELKKNS
                     EDVVKAYVESSEPVVQADQRAKDIVDRAERIANEIRIGSIEYAEDVLSSVEYNLREIL
                     EEVKRDKAELRPKK"
     gene            6329..8248
                     /locus_tag="KNP36_001871"
     CDS             6329..8248
                     /locus_tag="KNP36_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0873745.1"
                     /translation="MKERAKKILDFIIKNNNVTSQELQEKFNVSKRTIYYDILAINEQ
                     LGKSGNIKNVKHKFIFEGNLCDARKIISTEEDKFLDSDYRKTFILNKILLGEKISIEK
                     LTNEMLLSKNTVVQTITDVKKYLQTMGLRLEYKGKYKIIGDEYVIRELFLIIVQENIL
                     EINSISEEVSSFDTKGHIKLTDYSLLNLTKFVEFLNKRIRDGKTLYSYKYLNEAKKIS
                     YFSNCKELLCEEANENEQAYICTYISSLPSLNSEVKEDVVEEYVDKLIDKFEVNTAIK
                     LESKHEFKKNILRHLHSSYNRIRFKFPIRNPMLDETKYKHESLYKIIKSIIENEEEFP
                     VFEGIREEEIGFIAAYFGGYLRGSRDNGLRRNKVLLVCPNGLMVSKSLEIQLYKYIPT
                     IEIVGIVSIKQLKEVNVYYDYIITTIDIQNVNNVIVVNPLLTSSDVQLLMNKLISVKE
                     NEKYFNLELIIQAIRKNGVINNEEALKADLLNIIHKIDEGEMYQPMLKELINAERVNI
                     IKSVRDWKEAIKIASKPLLEDNSIEELYIENMIKSVEKYGPYIVLADRFALPHASSKE
                     GVNKLAMSLLIVEDEVDLLGKPVNIFMVLAAVDNTTHIRALASLSEMMYEEENVKLII
                     NGDKSSILELINKQN"
     gene            8261..8548
                     /locus_tag="KNP36_001872"
     CDS             8261..8548
                     /locus_tag="KNP36_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0873746.1"
                     /translation="MKILAVCGFGVGSSMVLKMTIQKALKQLGIECEVENTDINSARG
                     ADCDCIFTSQELLNELKGTCNVDVYPVKKYMDLAEVTEVVQTFLSDKNDKK"
     gene            8681..9940
                     /locus_tag="KNP36_001873"
     CDS             8681..9940
                     /locus_tag="KNP36_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HBF0873747.1"
                     /translation="MLDFISNNILRNPSMLIGLIAAFGLVLQKKKASDVIKGSLLAAF
                     GIIIMETGTGMLVSSIAPINGAFQSISGGAVTKGLSDVTFTASYGGIIGLAMFAGLAI
                     HLMIARFTPIKTIFLTGHMLYWFPFIFVASGVEAGLNGGVLIAFAAVLSALYWSIMPW
                     LLRKYVFDVIGDDSFTLGHPSGCLALISGFVAKLVGNKEKSTEDINIPQSLSFFREIS
                     ISGGMAVFLMFIVVGIVIPGAFKDSNEFIGTYAIKQGLSFGAGLIIMLHGVRMLINQI
                     MPAFQGISEKVVPNALPAFDCPILFNYKPNAVLMGFLVAMLTSTAMILICNYFNVFNL
                     LLIPLVITSFFECGAAAVIGESQGGIRGAIIGTAIAAIFMVVLVGISAVIYSGTIQNW
                     ILIFGGNDLSLFGIISRFIGSLFGGIL"
     gene            9943..10683
                     /locus_tag="KNP36_001874"
     CDS             9943..10683
                     /locus_tag="KNP36_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBF0873748.1"
                     /translation="MKFKYIDEIRRLIDIIENEEKVNMEKAVQIFVEAIESKNAIFSF
                     GASHAGILTEELFYRAGGCVLINPVFAKSLMLDTAPITHTSKMERLEGYGTALADKTP
                     IKKGDVVIVHSVSGRNPVSIEFAMKAKENKAIVICITNLSYSKSVSSRHSSGKKLYEV
                     CDLVIDNHGQKGDACVEIDGLNQKVSPTSTVIATTVMNSIIAQATQELVNKGLKNPPI
                     FYSANIDGGDELNKKIFDEYKSVIHYEY"
     gene            11006..12316
                     /locus_tag="KNP36_001875"
     CDS             11006..12316
                     /locus_tag="KNP36_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBF0873749.1"
                     /translation="MKKENKMEGIKVGMLKKLCSLAMVAIMTTTLITGCSSGNGKDSK
                     KDGEKEKLVLWMPPVENNMKEVWDPILDKFEEKNNCEVDLQIIPWDNYSEKFATAISA
                     GEGPDVGYMYAEMYPQFIESGAVEDLTNYATKEDKEQSIYIKTSEMMGGMYGMPFQAA
                     NPGVLYYNKDILEKLGEKPPKTWEDFKRICKKATQDTDGDGKIDQWGLAQGWGAKTFG
                     NLNWNWYPYLWQAGGDIFNDDLKSVKFNDKSGLEAAKFLKELQAYVPEDSLSKDSNEM
                     IESVFGPGKAAFTIMLSSAATSVFDESFPDLNWGFVTGLEDKKAATFGAVDHLSLISS
                     AKNKELAYKLIQHMLSVESMTEFHKAIPRAPITKGEPYQGDERFKEMVENDKNVYRPL
                     VVGPHGVEIYEYLWKELQTMISGDKTPKQALDDAAKYSNDLLAQ"
     gene            12414..13331
                     /locus_tag="KNP36_001876"
     CDS             12414..13331
                     /locus_tag="KNP36_001876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HBF0873750.1"
                     /translation="MENLVREFEENSKRKKTKLNIKPYMYILPLGIILVAFYVIPIIM
                     SIYFSFTKYNIISPATFIGLENYKKLFTDETLKVSIINTIKFTVVVVPCQTILSLILA
                     VWITGKGNSKIASFAKGAIFIPVLSSMVLIGMVWRALLNGEGSIIYQVLGAFGIESSK
                     LLGDSKTALPTLMFISMWKNIGYFMVIYISAIMNLPKHCYEVAKVDGATKLQEFIKIT
                     VPLLKPTTIMVVFLGSIWSLQVFDLIYTVTGGGPGISTMSIVMHAFNLNFKNFNSGYA
                     MTVANVLFLLIAVVSILQNKLVKRDNSDF"
     gene            13347..14156
                     /locus_tag="KNP36_001877"
     CDS             13347..14156
                     /locus_tag="KNP36_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HBF0873751.1"
                     /translation="MKTARRLLSDGLLLFIACASLVPFIYMLIISLKITYNSYSLDIS
                     FSTVTLQNYIDIFTKKGFAQYFFNTAIVSFSGVLLNLVFSTLAGYSFAKMDFKGSDKL
                     FLFMIMTLIIPSQVTMIPLYIIMKHLGWINSYLALIMPIPTAFGVFIMRQAILGVPKE
                     LLESAKIDGCSDFRILIQIVLPLIKPALITLAIFTFMGAWNEFMWPLIATTKDAMRTL
                     TVGLSTLKTFQITNYGQMMAGATITFLPPFIFYLILQSKFVEGVSLSGIKG"
     gene            14214..15962
                     /locus_tag="KNP36_001878"
     CDS             14214..15962
                     /locus_tag="KNP36_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4091 domain-containing protein"
                     /protein_id="HBF0873752.1"
                     /translation="MEISYVLKDCTFKHNKYSVVEAETWKDKDLDIVVAKGEKFAFQI
                     MLKATEEFNCTIDKSSAISWKGLGNRVRLALNMPNSLENNFSINILGYVQDDTKAFVN
                     DAILRDKDVLVEQYLPQTFWIEGQVPEDFEENNLDIGIDIFKSFGYEDEEKVCTIDVP
                     VKVRNVVLKPLDESKFFLDLWQHPSCLARMYKVELWSDIHFEIVDNYLKELASLGEKV
                     ATVIVSDYPWAGQSCYKVYKNPSNLYEYNMVSVSKGLDGKIKCNFESMDRYIGIADKY
                     KMAKEIDLFGLLGNWCAGEFGNPVEGYKDPIRVRYFDEKDKVFKFINNTNDLKEYIGL
                     VLNHLIECGLWDRVRIIADEPNNPEVVKECIEFINSTVGTHQVKYKSATHDQNFLDRA
                     KDEIDDMSINLKLTIQNYKDIESLKKKINDKGGILTWFVCCFPEKPNSFLSSPFVENR
                     IIGWYTYYFGLDGFLRWDYNLWTEDPWKDSSYKFPIWKAGDMFFVYPGKDLKPVRSVR
                     MENLRFGIQDFELFTMLEKEKVREYIEVELMQELLNKKENAEIKGFGDIELGYSLDNW
                     RYDKVKKYVLELLDRV"
     gene            16224..17246
                     /locus_tag="KNP36_001879"
     CDS             16224..17246
                     /locus_tag="KNP36_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 5 protein"
                     /protein_id="HBF0873753.1"
                     /translation="MFGGINIKRIGIIIMFFLSISFIGFYLVIRDNSDTVKMQRGINI
                     GNALESPKDFPWDVKMSNKFFDDIKDAGFDTVRIPVRFSDYTSDSDNFKIDEEFFKKI
                     DKYVDYALDKDLIVVLDLHHFEEIMKEPRVHKEKFLKIWQQIANRYQKYDKKLVFELL
                     NEPKENLSSQLLNEYIEEAIKIIRKTNPKRTIIVGPYNFYQIDYLNELNIPKDSNIVV
                     SFHYYEPNDFAFQGNIYHKGFEHLSNITWEGTNEQMDYLKKRFDTVENWANKNKVKIF
                     LGEFGITKEAPEVSRRAWIKAVREEAEKRNFSWAYWELASGFGIYNQIEGTWDRDILS
                     ALIEKR"
     gene            17251..19557
                     /locus_tag="KNP36_001880"
     CDS             17251..19557
                     /locus_tag="KNP36_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HBF0873754.1"
                     /translation="MKKNSKKILITLTIITNVIYILWRIFYTVPKEEGKFALICAIIL
                     LFVEIMGMMEMFVHYYGMSNIEYPEKPIISEELYPHVDVFIATYNESVDLVRKTVNGC
                     IHMQYPDKKKVHIYICDDGNREEMRILAEKMGVNYITRTEREGAKAGNLNNAMQHTTS
                     PLIATFDADMIPMHDFLIATVPYFLKNEQAKKDGEKEEYEKVGFVQTPQSFYNPDLFQ
                     FNLHSEGRIPNEQDYFYRDIQLARNRTNSVIYGGSNTVISREALEEVDGFYTYSITED
                     FATGILIQSKGYRCYAIPEVHASGLSPTDLKSLIKQRERWARGCIQTGRRLNILFRRG
                     LGFWQKISYISSITYWYASIKRFVYIMAPILFSVFNVIVVKCTLLQVLVFWLPMYILS
                     SLSLKIFSQNIRNTRWTNIYETIMFQSLMPAVILETFAISKNKFSVTNKSKLEENRMY
                     KFLQGIPYFIYMVLSIIGILKMFVAIFKMSSMTYSVVLFWLIGNLFNLVMATLFISGR
                     QQLRKSERYIAEIDFKLKQNSYVLSSKTIDISENGFAFLLENPEYISPEEEFEVEFRE
                     KSGNEMYIANMKAKIVNVVEVNSKWKYAAYITHIEDSEIDNWMCIVHDRIPTLPMTIS
                     NQLGFFDDLQINVKKRIEKTRTLSRRSPRINMNFQMDIKNTGKLRIVNFNYQYVLLNF
                     ENKSIYPKEIALEINENIVLECDLCEGKIDERGILYKVNNIDSIMQNFFLRDEMMDWI
                     LQNKTILVSKPSEKKEKSIDEFEPMEYI"
     gene            19529..20644
                     /locus_tag="KNP36_001881"
     CDS             19529..20644
                     /locus_tag="KNP36_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873755.1"
                     /translation="MSLNPWNIFRRDEMKTLKVFFCSTKYLILVFIFFINTTFISSAT
                     SDKILDLSFKKIETDLNSKITYEDTGVKIETDSSKSDKERYLYIYQNIKENWSMYNNF
                     YIEIQNKNKSSQRINLSIQSKNMLEFRLKEGSEVFLEGKNIIYSDKIKEGCIEVPGEF
                     EGKIYVNFNSLINEESNVVLDSNMLSNIVSWGITFIPSDEEHNIVIIKKISLLSEEKL
                     RFLNNIKIIGDEEVQIPVLGQSISQYEVLGLKSDSKIKYSLMGKQDNVSISQKGKLTL
                     SNKAKPGQIILQVNVDDKFKIGKKITLTESWSVNKKDKDGVPYTLVYPEQSPTVQDMK
                     KINFMNNIITFVRILFVSLVIICFGIYLYWKKCSKTK"
     gene            20662..22080
                     /locus_tag="KNP36_001882"
     CDS             20662..22080
                     /locus_tag="KNP36_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBOAT family protein"
                     /protein_id="HBF0873756.1"
                     /translation="MLFSSLIFLFYFLPITLVLYYVFRFNRTIQNMILLAVSLFFYAW
                     GEPKFVVIMIVSIIMNYIFGLLVDRYRESKIKVKVFLVLMCAYNIGVLFIFKYLAFAL
                     RNISELISTELTIPSIVLPIGISFFTFQGMSYVIDVYRRHGEVQKNPFYVGLYIAFFP
                     QLIAGPIVRYESVAEQILNRKETWNKFSIGTCRFITGLGKKVLISNNMAIVADYIYTM
                     NSQGEIAASLAWLGSIAYTLQIFFDFSAYSDMAIGLGLMFGFKFEENFNYPYISKSIS
                     EFWRRWHISLGMWFKSYIYFPLGGSRVANKDIMIRNMFIVWLFTGIWHGAEWTFVIWG
                     ILNFVFLIIERFIMFEKIENHNFIKHIYALLVVNFGWVLFRSPNLKEAYNYFKAMFGG
                     NGAIWSDYTYMFLKEYWVFFIFAFIFSVPIAKKINKFVVEQAKYSMIFNVFYPISAIL
                     LFFISVTYLVTGSYNPFIYFNF"
     gene            22095..23303
                     /locus_tag="KNP36_001883"
     CDS             22095..23303
                     /locus_tag="KNP36_001883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873757.1"
                     /translation="MNRFFKVRLITAIMFLIILFAFSIFNVCYSGKDTIQEIKNSIAE
                     KSSLKDTISSIDNTVNDKVIYKNTFIETYGYLQKLMGKNEFSKFSVVKDTSGKMHYTY
                     FAKAPNPVGVIADRVRKFSDEMEKQNTKLVYLMTPDKYIKGVTKFPKGIPYSYSNETA
                     DNFLNQLKKYNVDYIDFRENILKSGIPKDDLFFKTDHHWKVETSFWAFGELVEQLNKK
                     YNMNLDENHYYRDKDNYNSIVYPKSFLGSMGRKTGILYGGIDDFTLIYPKFKTNYTYY
                     TDSKSQKFELKGRFEESLILSYPFNADLDLMDGQSDKYFTYLLGNRPLVKIKNIENPD
                     GLKVLFVKDSLIVPTAAFFSSVCSSIDMIDPRYYDGDILEYAKSHDYDFVFISVYPQN
                     LTKEFFPFCE"
     gene            complement(23377..24765)
                     /locus_tag="KNP36_001884"
     CDS             complement(23377..24765)
                     /locus_tag="KNP36_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="HBF0873758.1"
                     /translation="MESSFLSQFLMITDFKTIFFIILLLGTFFIVRQFEKKKIKFSLR
                     TIYATVLGLILGIIIQAFAGFPNDTTQVIWLQEVSKWYSLFGSGFMDLLKMLVVPLVF
                     LSIIKVIINMKDNNLGTLTFKSLGMLLATTAIAAIVGIIVANIMKLGVGANMPTLVEN
                     QELKEINSLVDTLRGLLPSNPVMAMANGNIVATIIFATFIATSIKRLSKKHFETIKPF
                     IGFIEASYKIIVSVSMTVIKFMPYAVVALLANTITSQGISSIVSVLQFILALYISVAI
                     LFIIHLIFITLNGLNPITYIKNSTEALLLAFTSRSSLGTLPVTIESLVQNHGVDEGVS
                     SFTASLGANMGMNGCAGIYPALMAVTLANMAGVNMDMSFYVMLLIVITISSFGIAGLP
                     GTATMAVSVVISGVGLGSYFPLVGGILAIDPILDMGRTMINVNGAMVSSITVGKSLGK
                     IDKEVFSKKNIS"
     gene            25106..26440
                     /locus_tag="KNP36_001885"
     CDS             25106..26440
                     /locus_tag="KNP36_001885"
                     /EC_number="1.8.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-disulfide reductase"
                     /protein_id="HBF0873759.1"
                     /translation="MRVIIIGGVAAGMSAAAKLKRIKPEYEVVVYEKTEIVSFGACGL
                     PYFVGGFFNDADELLARTPEKLREAGIDLNIFREVVEVDSESKKIKVKNIKTDEIYED
                     YYDKLMIATGARSIMPPIKNIKLKNVSTLKSLYDGEYLKKLLSNEDNKRVTIIGAGFI
                     GLEAVEACKKLGKDVDVIQLEDRILPQVFDKEMTDVLEEEINRHNVNLHLDEMVVELC
                     GEDKVEKVITNKGEIDTDVVIIATGVRPNTEFLSNTNIKMLKNGAIVVDEYGRTSVED
                     IYSAGDCATIKNIVSNENVYVPLATGANKLGRIVGENLAGREISYQGSLSSSCIKIMD
                     MEAASTGITERQAKDLGINVKSKFISDYNQTHYYPGRNKIYVKLIYDADTKVILGGQV
                     AGFKDAVQRANVLAAAIFGKMTTNQLGMLDLCYAPPFARTWDVLNVAGNVSK"
     gene            complement(26582..27499)
                     /locus_tag="KNP36_001886"
     CDS             complement(26582..27499)
                     /locus_tag="KNP36_001886"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011969064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HBF0873760.1"
                     /translation="MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSM
                     KLKKCGFKDIDLICITHLHGDHIFGLLGLLSTIGNSGRTSDLTIVGPVGIVDCIRSMR
                     NLVEYVPYTLKIIENPQGNFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDI
                     DKATKNEVPKILWNKLQEGQNIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPD
                     FIKDSDLFICEAMYGDDLDISKAVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIP
                     SMYLENATNVFENTILGEDRLSLRLNFDE"
     gene            27707..28591
                     /locus_tag="KNP36_001887"
     CDS             27707..28591
                     /locus_tag="KNP36_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4846 domain-containing protein"
                     /protein_id="HBF0873761.1"
                     /translation="MKVLKKITILSLITLTLVGCSNGEEKKVVEGSKKTQNSKKDEQP
                     IIVHKDANILKDRYEPPKGFKRVDVEKGSFESFLRNTKLKNYGEKVKYYDGRTKESKG
                     IYDSVFDVDIGNRDLHQCADAIMLMRAEYLYQNKLYDEISFDFVDGFKAKYSKWAQGY
                     RISVKDSGSSWYKATEYSTSYESFRKFMDIVFAYSGTLSLEKELEPVKVEDMKIGDVF
                     IVGGSPGHASIIMDMAENEKTGEKVFMIAQSYMPAQQTQLLINRKNPNLSPWYSLDFE
                     GDLTIPQWTFKRDQLKRF"
     gene            28804..30645
                     /locus_tag="KNP36_001888"
     CDS             28804..30645
                     /locus_tag="KNP36_001888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional metallophosphatase/5'-nucleotidase"
                     /protein_id="HBF0873762.1"
                     /translation="MKIRRYLILVIIILITTSQSFISYGLERFEEITIFHTNDIHGRY
                     AEGDDHIQIGNLATLKKETPNSILVDAGDCLHGLPIVNMDRGKSAIELIKCAGYDYIT
                     PGNHDFNYGKDRLFELSKSANLGENTLKFLSSNIFENGKKVFDSNDIKEIDGIKIGFF
                     GLSTQETKSKTGFKNVEGLEFKNPIESATEQVNELKGKGANVIVAICHIGTNSLSKPN
                     SIDIANEVQGIDLIIDGHSHTKFENGKQVGDTLIVSAGQYLENIGEIKLTLDTNDVED
                     IKIENKSARLIGKEEALKYKLDSVVSKKVDKIKEQQEKILDKVIGVTTNTLDGSYENV
                     RTKETNLGNLISDILLDKTKADISLFNGGNIRDTIEKGNITRRDIVDVFPFSNTIVTK
                     ELTGAQIKDVLEHGVKLYPEKSSAFLQVGGISYYFNPKQKEGEKITNIQKEGKPLDLN
                     KKYVVATNDYIASGGDEFPCFSKEPVLKEFGNLESAVIEYIEYKKEISKNVDGRIGIK
                     SKDELISKNHESDLILSENEKNINDNEENLSNNIKSSDSDKNKSLDKTSSRESSNLGI
                     SKREAKEKSPKTGDLGFSNSIIIFIVSSTLICLLNFNQKELKDKKSK"
     gene            30950..31657
                     /locus_tag="KNP36_001889"
     CDS             30950..31657
                     /locus_tag="KNP36_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873763.1"
                     /translation="MNNILLLEDDKSLNRGISFKLKKEGYNVFSAFGIEEAKNIFAKE
                     EICLIISDIGLPDGSGFDFCEEIRKKSDVYIIMLTALDEEVDIVTGYDLGADDYITKP
                     FSLMVLISKVNALMKRVNTVKNYTLLVCDDLFFYYIENKLIIRTDDKEEEIILSKTET
                     KLLKYLMENSMQTLTKEQLLESLWDSSGNFVDDNTIAVNIRRLRQKVEKNPSEPKYIK
                     TVRGVGYMWGERSIKKC"
     gene            31651..>32040
                     /locus_tag="KNP36_001890"
     CDS             31651..>32040
                     /locus_tag="KNP36_001890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0873764.1"
                     /translation="MLKNMNLKDGLSVKDDYIMRRVIVYSVLSVLIVTLVFILFEYSR
                     LHKLYEHQIKNTQNVAGILIEKYPNDEIDIVNSIYNSDYSKVSTGEKAFKKFGYGLEN
                     KMSNDKNFSLYLKSFFKESFFIFLMMFI"
BASE COUNT        12619 a         3348 c         5692 g        10381 t
ORIGIN      
        1 atttggaaaa taattattat ttttctttga atatatatac tatagaagaa attttatcca
       61 aaaacttttc taggtttaaa ttataccata tttatagtat gatatgatta taattttata
      121 taataaataa gtaaaaatag taaaaaataa attaagaaat gtttttaata aaaataagct
      181 taagggggtc aaccatgagt gcaaaggtaa cgaatcaata tggaaatata gaaatagata
      241 atcaagtaat agctcaagtc gtatatagag ctgcaatgga aagttatggc ttagtaggtt
      301 tagcatataa gtctaaagga atagtagagc tattaaaagg cgagaacgca actaaaggtg
      361 taagagttga ggaagtagaa gaagatgcca tagcaatcga actttatgtt ataatacaat
      421 atggtacaaa tatatctact gttgccaata atataataga tagagtaaaa tatgtagttg
      481 aaaaaatgac tggcgtaaga gttactagaa ttgatattaa tgtacaagga ataagagtta
      541 agtaatttca taggaggaaa caaatgattc aatatataga tggtaaaagg ttaagggaga
      601 tgtttatttc aggtgcaaac aatctccaaa acaataaaga gttagttgac aagttaaatg
      661 tattccctgt accagatgga gatacaggaa ctaatatgtc attaacaata tcttatgcct
      721 taaaagaatt agcaaaagtt gaaaatgata atatatcaga tatcggaaaa gcattatcta
      781 aaggttcttt aatgggagct agaggaaact caggagttat actttcacaa ataatcagag
      841 gtatagctaa atctatagaa ggaaaaagta aattatcaac agaagattta gcaaaagctt
      901 ttaaaaatgg ttcagacaca gcatataaag ctgtaataaa accaattgaa ggaactatac
      961 ttactgtagt tagagaaagt ggagagtttg caataaaaac tgcgaaaaaa gagaaagatg
     1021 tagtaaagtt tttaagtatg cttgtgaagg aatcaaattc ttcattagaa agaactccag
     1081 accttctaaa gaatctaaaa gaagctggtg tggttgactc tggtggaaag ggtcttgtac
     1141 ttatatatga aggaatgtta gcttctataa aaggcgataa catagaaata aaaaatgttg
     1201 acctagatac taatatttca acaagtatgg attttgcaaa gagtactact agcacagatg
     1261 atataaaata ttgctattgt acagaattta ttttagaaag ttctaaggta gaagatacta
     1321 aaataagaga cataatgatg gcttatggtg atagcctagc agtagttgga gatgatggag
     1381 tcataaaggt acatgtacac actaatgacc caggaaatgt acttcaagaa gctctaaagt
     1441 acggtcaatt attaactata aaaatagaaa atatgaagtt acaacatgaa aatacattac
     1501 tggatgtaga agaaaagaaa gaaaatgata gtgaaccttt agaagaagaa aaagagtttg
     1561 ggtttatagc tacttctatg ggtgaaggtt tggcaaatat atttaaagat ttcggagttg
     1621 accatataat agaaggtggt caaactatga atccaagtac tgaagatttt atgaatgcta
     1681 taaagcatat aaatgctaaa aatatattta ttttcccaaa taacagcaat ataataatgg
     1741 ctgctaatca ggcaaaagaa ttgagtgata aaaatataat agttatacct acaaaaaata
     1801 cgcctcaagg atttgctgca ttagtaactt ttaatggaga attaagcgaa gatgaaaata
     1861 aagaagctat gatgaatgct ttaaactcag ttaaatcagg tcaagtaact tttgctgtta
     1921 gggatacagt gatgaatgaa attgatgtta aagaaggtaa tataattgga attgcagaag
     1981 gaaatttatt atcagcagga gattatgtgg atgaagtaac atcaaacctt attgaaaagt
     2041 tggttgatga agatactgct ataataacat tattctttgg tgaagatgtt acagaatctc
     2101 aagcaaatga actacgtact tctttagaag aaaagtttga agatgtagat gtagagttat
     2161 attatggagg acaacctctt tattattact taatttcagt tgaataatga ttataagaac
     2221 ctgtatgacc aagtagcttt tataaaattg gttgtacagg atttttgtgt agtaggtgat
     2281 atatttgttg gatttatata aagatgttca atatgttaag ggaataggac ctaaaaaagc
     2341 agataaatta aataaactgg gtatatttac actaaaagac ctattgtatt attttccaag
     2401 acaatttgaa gatagaaata atctaaagaa aatagcacaa ttagaagatg gtgagaaagt
     2461 tacgataaaa gcagtaatat caagtataaa tacatttagc ccaaaagaag gtatgacttt
     2521 aacaaagatt gatgtaaaag atgagacagg ctcggctaaa ttagtgtttt ttaataagag
     2581 ttatataaaa aatacttttc gtccaggaga ttcaatatta gtttttggga aggttaagaa
     2641 aaaatttaat aacttagaac ttacatcatg tgaattagaa tatcttacta attcacctaa
     2701 gaatacatgt agatttatgc ctgtgtacca gcttacatac ggtgttacaa ataaagaaat
     2761 tatgagtata attagaacag tacttgaaga taaagaatta attatacaag aatatatgcc
     2821 acaaagaatt atagaaaaat ataggctatg tagtatagat tttgcagtta gaaacataca
     2881 ttcaccaagt agtaaggaat cattaaaaat agctttatat agaattgtat ttgaagaatt
     2941 acttatacta caactagggt tgtttgtatt taaaagtggc agaaataaag aagatggaat
     3001 aaagtttgaa acaagtaaag acttaaaaaa aataataagt gctttaccat ttaaactgac
     3061 taaagctcaa aacagggcat tagatgaaat tatacaagat atgaatttag agaaaataat
     3121 gaatagattg gtacaaggtg atgtagggag tggtaaaaca gtagtagctc tcttagcact
     3181 tgcaaattgt gttttaaatg gttatcaggg cgctttgatg gcacctacag agatattagc
     3241 agggcaacat tatatttcac ttactgagtc tctaaaagat tttggaataa atgtaggtct
     3301 attaataggt agtcttacaa aaaaacaaaa ggatacagta ttggaacaaa taaagaataa
     3361 tgagattgat atattaatag gtacacatgc actaattgaa gataaggttg aatttaataa
     3421 tattggttta gttataacag atgaacaaca tagatttggt gttatgcaaa ggagcaaact
     3481 ttcattgaaa ggagcaaatc ctgatatatt agtaatgaca gcaacaccaa taccaagaac
     3541 tttagcactt atactctatg gagatttaga tatttctatt atagatgaac ttcctccagg
     3601 aagacagcca atagaaacaa ttgctattga aaaaagtaag cgagatagag catataataa
     3661 tcttgtaaga agagaggttg aatcaggaag acaagtgtac attgtatgtc ccttggtaga
     3721 agaaagtgaa gccatagaag ccaaatcagc agttgaactt gttgaggagt taagagcgga
     3781 atattttcac gacttaaggc ttgggttgct tcatggtaaa atgaagtcaa gtgaaaaaga
     3841 tgaagtaatg agacttttta aagataaaga aatagatatt ttagtttcaa caacagtaat
     3901 agaagttggt gtcaatgtgc caaatgcaac attaatgata atagaaaatg cagaaagatt
     3961 tggacttgca caattacatc agcttagagg gcgagttgga agaggtagtc ataaatcgta
     4021 ttgtgtacta atttatgatt ctaaaacaga tgtatgtaga caaagaatgg ctataatgga
     4081 agagaccaat gatggtttta agatttcaga gaaggattta gaaataagag gacctgggga
     4141 attttttggg acaaggcagc atggtcttcc agaacttaag gtagcaaact tatttaagca
     4201 tataaaaata ctgaagttag cacagcaaga agctcgatat atattgggtg aagataataa
     4261 tctacaatta aaagaaaaca tggcactcaa aaaagaaatt atagataaat ttaaagatac
     4321 attgaaagaa atttcattaa attaatttta aattgtgtta aaatattact aatgtaataa
     4381 tgtgctgaag ggagattgtc atattgagag taatttcagg aaaagcgaga ggattaaaac
     4441 taaatactcc aaaaaatgaa gatgtaaggc caactacaga tagagtaaaa gagtctctat
     4501 ttaatatgat aaattcatat ataatggaaa gtgaagttct ggatttattt gctgggactg
     4561 gttctttagg aatagagtgc ttatctaggg gtgccaagtc atgtactttt gtagatatta
     4621 gtaaggaaag catagatatt gttaagtcca atataaaaaa ggcaagagtt gaaagtgaaa
     4681 gtattatttt aaaccttgat tttaagactg caatagataa acttaaatta caaaatagta
     4741 aatttgacat aatttttatg gaccctccgt attataaaaa tatgtttata gaagctattg
     4801 aaaaaattga taattctaat ctattgaacg aagatggaat aatagttgta gaacatgata
     4861 cgaatgattt atttccagat aagatatgta aattggagaa aactagagat aagaaatatg
     4921 gaaatactac attaactttt tataagatgg aggcataata tggaaaataa acctagaaaa
     4981 gctatatttg caggaagttt tgacccaatt actaatggac atttagatat tatttgcagg
     5041 gcttcgaagt tatttgacga attacaaata ggagtattaa ataatcctaa taaaaagggt
     5101 ctatttagct ttgatgaaag agtaaaactt atagaaaaaa gtacaagcca tttaaataat
     5161 ataaaagttg tgacttttga tggtttatta ataaattact gtcaggaaaa tgggattgga
     5221 gcattagtta gaggtgtgag aagtggtgct gatgttgatt atgaacttca gatggcacat
     5281 atgaatagag agcttaatcc agatatagag actataattt taccaagttg tacaaaatat
     5341 tcatttataa gttcatcttt aataaaagag gttttgctct ttgatgctga tataaaaaat
     5401 ttggttccaa agattgtttt ggaagaatta aagaaaaaaa ctagtggggg taattgatat
     5461 atgaagatag atttagaaat gattgaacta tttgagcagt tagaggagat atttagaagt
     5521 gcttctacaa tccctttctc acataaatgc acagtggata aagatgaggt tttagcaata
     5581 attaatgata taagaacttt aataccagaa gaagtaacac aggcagtatg gattaataaa
     5641 gaaagaaata aaataataag tcaagctaag caagatgcta caaatatagt tgaacaagcg
     5701 aaaaaagaag ctgagagaat acaacaagaa tatcaagata atatagagga attaaagaaa
     5761 aattctgaag atgtagtaaa ggcatatgta gaatccagtg aacctgttgt tcaagcagac
     5821 caaagagcaa aagatatagt tgatagagct gagagaatag ccaatgagat aagaattggg
     5881 tcaattgaat atgcagagga tgtgctttct agtgttgagt ataatttaag agaaatatta
     5941 gaagaagtaa aaagagataa agctgaactt agacctaaaa aataaatttt aaataaataa
     6001 aaatggagct atcacacaaa aaattccaat ttatgtgtga tagctctctt ttaatatagc
     6061 aattttttgt tatataattg tgctttttag attacttata tcttattttg atattataat
     6121 gtagtttaat cttttatttg ttgaaatcaa cttatttatt tgtataaata atataggtta
     6181 ttttcaaatt tttttaataa ttttaccact gtcttctttt agattagagt tagactgtgc
     6241 aaaattataa aataatacta aatcatgtgc aattatttgg tatggcacta catgtagaaa
     6301 atatagataa taaaattaag gaggtagtat gaaggaaagg gctaaaaaaa tattagattt
     6361 tattattaaa aataacaatg taacatcaca agaactacaa gaaaagttta atgtttcaaa
     6421 gagaactatt tattacgata ttctagctat aaatgaacaa ctaggaaaaa gtggtaatat
     6481 aaaaaatgta aaacacaaat ttatatttga aggtaattta tgtgatgcaa ggaaaataat
     6541 ttcaactgaa gaagataaat ttttagatag tgattacaga aaaactttta tattaaacaa
     6601 gatattactt ggcgaaaaaa tatcaataga aaaactaaca aatgaaatgt tactttcaaa
     6661 aaacacagta gtacaaacaa taactgatgt aaaaaaatac cttcaaacaa tggggttaag
     6721 attagagtat aagggaaagt acaaaattat aggtgatgaa tacgttatta gagagctgtt
     6781 tctgataatt gttcaagaaa atatattgga aattaattct ataagtgagg aagtaagtag
     6841 tttcgataca aaaggacata taaaacttac tgattattct ttattaaatc taactaagtt
     6901 tgtggaattt ctaaataaaa ggataagaga tgggaaaaca ttatactcat ataaatatct
     6961 aaatgaagct aaaaaaatta gttactttag taattgtaaa gaacttttat gtgaagaagc
     7021 taatgaaaat gaacaagcct atatatgcac ttacataagt tcacttccca gcttaaatag
     7081 tgaagttaag gaagatgttg ttgaagaata tgtagataaa cttatagata agtttgaagt
     7141 aaatacagca ataaaattag aaagtaagca tgagtttaag aaaaatattt taaggcacct
     7201 ccattcttct tacaacagaa tacgatttaa gtttcctatt agaaatccaa tgttagatga
     7261 gactaagtat aaacatgagt cactttataa aattataaaa tcaattatag aaaatgaaga
     7321 agagtttcct gtatttgagg ggataagaga agaagaaata ggatttatag cagcgtattt
     7381 tggaggatat ttaagagggt ctagggataa tggtctaaga agaaataaag tcttactagt
     7441 ttgtcctaat ggtcttatgg tatcaaagag tttggaaata caactatata aatacatacc
     7501 aaccatagaa atagtaggta tagtatccat taagcaacta aaagaagtaa atgtatacta
     7561 cgattacata attacaacta tagatataca aaatgtaaac aacgtaattg ttgtaaatcc
     7621 tcttttaaca tcatcagatg ttcaattact tatgaacaaa ctaataagtg taaaagaaaa
     7681 cgagaagtat ttcaatcttg aattaataat acaagctata agaaaaaatg gagttatcaa
     7741 taatgaagaa gcactaaaag ctgatttatt aaacataata cacaagatag atgaaggaga
     7801 gatgtatcaa ccaatgttaa aggaattaat taatgcagaa agggtcaata taataaaaag
     7861 tgttagagat tggaaagaag caataaaaat agcctcaaag ccattgttag aagataactc
     7921 tatagaagag ttatatatag aaaatatgat aaagtcagtt gagaaatatg gaccatatat
     7981 tgttttagct gatagatttg ctctaccaca tgcaagttct aaagaaggag taaacaagct
     8041 tgctatgtct ttactaatag tagaagatga agttgattta ttaggaaaac cagtaaatat
     8101 atttatggta ttagctgctg tagataacac tactcacatt agagcattag catcactatc
     8161 agagatgatg tacgaggaag aaaatgtaaa actaataatt aatggtgata aaagttcaat
     8221 actagaactt ataaataagc aaaattagga ggaatgaaaa atgaagatat tagcagtatg
     8281 tggttttggt gtaggttcat caatggtatt aaaaatgaca atacaaaagg ctctaaagca
     8341 gttaggtata gaatgtgaag tagaaaatac agatataaat tcagctagag gtgctgattg
     8401 tgactgtata ttcacaagtc aagaattgtt aaatgaatta aaaggaactt gtaatgtaga
     8461 tgtatatcca gttaaaaagt acatggattt agcagaagtc acagaagttg ttcaaacttt
     8521 tttaagtgat aaaaatgata agaaatagta taagttttaa aaagtaaatt taagttaatc
     8581 agaataaaat aaaaacttac taaattcaaa aatagtaaga aagagaggag ggatttagtg
     8641 gtagaaaact taaacagttg acctatcact aaaaaatata atgcttgatt ttatttcaaa
     8701 taatatttta cgtaatccat ctatgttaat tggattaata gcagcatttg gtcttgtact
     8761 acagaagaag aaagcatctg atgttataaa ggggtcacta cttgcagctt tcggaattat
     8821 aattatggag actggaacag gtatgttagt tagttcaata gcaccaatta atggagcttt
     8881 ccaaagtata agtggtggtg cagtaacaaa aggtttaagt gatgttactt ttactgcaag
     8941 ttatggtgga attataggtt tagcaatgtt tgcgggttta gctattcacc taatgatagc
     9001 aagatttact cctattaaga caatcttttt aacaggtcac atgctttatt ggttcccatt
     9061 catatttgta gcttcaggag ttgaagctgg attaaatggt ggagtattaa tagcttttgc
     9121 agcagtatta tcagcactct attggtcaat aatgccttgg ttattaagaa aatatgtgtt
     9181 tgatgttata ggagatgatt cttttacatt aggtcatcca tctggttgtt tagcacttat
     9241 atcaggattt gttgctaaat tagtaggaaa taaagaaaaa tctacagaag atataaacat
     9301 acctcaaagt ttatcatttt ttagagaaat atctataagt ggtggaatgg cagtgttttt
     9361 aatgtttata gttgttggga tagtaatacc aggtgcgttt aaagatagta atgagtttat
     9421 tggaacgtat gcaataaagc aaggtctttc ttttggagca ggtcttataa taatgcttca
     9481 tggggtaaga atgctaataa atcaaataat gccagcattt caaggtatat ctgaaaaagt
     9541 tgtgccaaat gcactacctg cttttgactg tccaatatta tttaattata aaccaaatgc
     9601 tgtattaatg ggattcttag ttgctatgct aacatctaca gctatgattt taatatgtaa
     9661 ctactttaat gtatttaatt tgctacttat accacttgtt ataacttcat tctttgagtg
     9721 tggagcagca gcagtaatag gagaatcaca aggtggtata cgtggagcta taataggtac
     9781 agctatagct gcaatattta tggtagtttt agtaggaata tctgctgtaa tttactcagg
     9841 aactattcaa aattggatac taatatttgg aggtaatgac ctttcattat ttggtataat
     9901 cagtaggttt ataggttcac tatttggagg aatattatag atatgaaatt taaatacata
     9961 gatgagataa gaagattaat tgatataata gaaaacgaag aaaaagtcaa tatggaaaaa
    10021 gcagtacaaa tctttgttga agcaatagaa agtaaaaatg ctatattttc atttggagct
    10081 tcacatgcag gaatattaac agaagaatta ttctatagag caggtggctg tgttcttata
    10141 aatccagtat ttgcaaaatc tctaatgtta gatacagcgc ctataactca cacaagtaag
    10201 atggaaagat tagaaggata tggtacagct ctagctgata aaactccaat taaaaaagga
    10261 gatgtagtta tagttcattc agtatctggt agaaatccag taagtataga gtttgctatg
    10321 aaagctaagg aaaataaggc aatagtaata tgtataacta atttaagtta ctcaaaaagt
    10381 gtatcttcaa gacattcttc aggaaaaaaa ctttatgaag tatgcgattt agtgatagat
    10441 aatcatggtc aaaagggaga tgcctgtgta gagatagatg gattaaacca aaaagttagt
    10501 ccaacttcta ctgtaatagc aactactgtg atgaactcta ttatagctca agctactcag
    10561 gaattagtta ataaagggct aaagaatcct ccgattttct atagtgcaaa tattgatggt
    10621 ggagatgagt taaataagaa gatttttgat gaatataaaa gtgtaattca ttatgaatat
    10681 taaggttaaa aaaatatgtt aatgaacttt gaagtttatc aacaaagaat attaataata
    10741 tataataaat gctatcattt aaaagctgta ggtaaaaatc tacagctttt tattattgta
    10801 gattaaaaag atgcgtaatt aaattttaaa ttggagaaaa taaattggaa ggtatcaatt
    10861 ataaatatta gaaacgttgt catagaaaaa aactatatta aaaaaaagta catagaaaaa
    10921 actgattaga caataaatac atgctttgat aatattttaa atggagtgaa aatgtgtaga
    10981 attataatga aaaaagaaaa taaaaatgaa aaaagaaaat aaaatggagg gaataaaagt
    11041 gggtatgtta aaaaaattat gttcactagc tatggtagca attatgacta caacacttat
    11101 aacagggtgt tcaagtggaa atggaaaaga ttcaaaaaag gatggcgaaa aagaaaaact
    11161 agttctttgg atgccaccag tagaaaataa tatgaaggaa gtttgggacc ctattttaga
    11221 taaatttgag gaaaaaaata actgtgaagt agatttacag ataattcctt gggataatta
    11281 ttctgaaaaa tttgcaacag ctataagtgc tggcgaaggt ccagatgtag gatatatgta
    11341 tgcagaaatg tatccacagt ttatagaaag tggagcagta gaagatttga ctaactatgc
    11401 aactaaagag gataaagagc aatctattta tataaaaaca tctgaaatga tgggtggaat
    11461 gtatggtatg ccattccaag cagcaaatcc aggggtatta tactataaca aggatatttt
    11521 agagaaacta ggagaaaaac ctcctaaaac atgggaagat tttaaaagaa tttgtaaaaa
    11581 agcaacgcaa gatactgatg gtgatggaaa gatagaccaa tggggattag ctcagggatg
    11641 gggagctaaa acttttggta acttaaactg gaactggtat ccttatttat ggcaagctgg
    11701 tggagatata tttaatgatg atttaaaatc ggttaaattt aatgataaga gtggtttaga
    11761 agcagctaag ttcttaaaag aattacaagc atatgtgcct gaagattctt tatctaaaga
    11821 tagtaatgaa atgatagaaa gtgtatttgg accagggaaa gcagcattta caataatgtt
    11881 atcttctgct gcaacaagtg tatttgatga atcattcccg gatttaaatt ggggatttgt
    11941 aactggacta gaagataaga aagcagcaac ttttggagca gtagaccatt tatctttaat
    12001 ctcatctgcg aaaaataaag aacttgcata caagttaata caacatatgt taagtgttga
    12061 atcaatgaca gaatttcata aagcaatacc aagagcacca ataacaaaag gtgaaccata
    12121 tcaaggtgat gaaagattca aagaaatggt ggaaaatgac aaaaatgtat atagaccatt
    12181 agtagtagga cctcatggag ttgaaatata tgaatattta tggaaagaac ttcaaactat
    12241 gatttcagga gataaaactc caaaacaagc gttagatgat gctgcaaaat attcaaatga
    12301 tttattagca caataaaagt ttaaagctgt aatatgttgt aaagtacttt acagattaaa
    12361 attagcattg tatttataaa tacaatgcta atatttatat tggagaggat aaaatggaaa
    12421 acttagttag agagtttgaa gaaaattcaa aaagaaaaaa aacaaaatta aatattaaac
    12481 catatatgta tatattgcca ttgggaataa ttttagtggc gttttatgtg ataccaataa
    12541 taatgtcaat atactttagt tttacaaagt ataatattat tagtccagct acttttatag
    12601 gtttagaaaa ttataaaaaa ttatttacag atgaaacatt aaaagtatct attataaata
    12661 ctattaaatt tactgttgtt gtagtacctt gccaaactat attatcattg attttggctg
    12721 tttggattac aggaaaagga aatagtaaaa tagcttcatt tgctaaaggt gctatattta
    12781 taccagtatt atcatctatg gttttgatag gtatggtatg gagggcttta ttgaatggag
    12841 aaggttctat tatatatcag gtattaggtg cctttggaat agaatcatct aaacttttag
    12901 gagatagtaa gacagcatta cctacactta tgtttatatc tatgtggaaa aatatagggt
    12961 atttcatggt aatttatatt tcagctataa tgaatttacc aaaacactgc tatgaagtag
    13021 cgaaggttga tggggctaca aaacttcaag aatttataaa aataactgta cctttattga
    13081 aaccaactac aataatggtt gtatttttag ggtcgatatg gtcattacaa gtatttgact
    13141 taatttatac tgtgacaggt ggaggtccag gtatatctac tatgagtata gttatgcatg
    13201 catttaactt aaactttaaa aactttaatt ctggatatgc aatgactgta gcaaacgtat
    13261 tatttttgtt aatagcagta gtttcgattt tacaaaataa gcttgtaaaa cgagacaatt
    13321 cagattttta gaaaggtagg tataatatga aaacagcaag aagattatta agtgatggtt
    13381 tacttttatt tatagcgtgt gcaagtttgg taccttttat atacatgttg ataatatcat
    13441 tgaagataac atataactca tatagtttgg atatatcttt ttcaacagta acccttcaaa
    13501 actatataga tatttttact aaaaaaggat ttgcacaata tttttttaat acagcaatag
    13561 tatctttttc aggtgtatta ttaaatttag tatttagtac attagcagga tattcttttg
    13621 cgaagatgga ttttaaaggt agtgataagt tatttttatt tatgataatg actttaatta
    13681 taccttccca agttacaatg ataccactat atataataat gaaacactta ggatggataa
    13741 atagttatct tgcacttatt atgccaatac caactgcatt tggcgtattt ataatgagac
    13801 aagctatttt aggagtacca aaagagttat tagaatcagc aaagatagat ggttgttcgg
    13861 attttagaat tttaatacaa atagtgttgc ctttaattaa accagcatta attacactag
    13921 caatatttac ttttatggga gcatggaacg agtttatgtg gcctcttata gctacaacta
    13981 aagatgcaat gagaacatta acagttggat tatctactct taagacattc cagataacta
    14041 attatggaca gatgatggca ggggctacaa taacattttt acctccattt attttctatt
    14101 tgattttaca gagtaaattt gttgaaggtg tgtctttgtc tggtataaaa ggttaaatag
    14161 tctaatttaa taatatataa agaaacttat ataaatatgg aggaatttaa actatggaaa
    14221 tttcatatgt actgaaagat tgcacattca aacacaataa atactcagtt gtagaagctg
    14281 aaacttggaa agataaggat ttggatattg tagtagctaa aggtgaaaaa tttgcatttc
    14341 aaattatgtt aaaagcaaca gaagaattta attgtacaat tgataaaagt agtgctatat
    14401 catggaaagg cctgggaaat agagtaaggt tagcattaaa tatgcctaat agtttagaaa
    14461 ataattttag tataaatata ttaggatatg ttcaagatga tacaaaggca tttgtgaatg
    14521 atgctatttt aagggataaa gatgtgttag tagagcaata tttgcctcaa acattttgga
    14581 ttgaaggtca agtaccagaa gattttgaag aaaataacct tgatataggt attgatatat
    14641 ttaaaagctt tggatatgaa gatgaagaaa aagtttgtac aattgatgtt cctgtaaaag
    14701 taagaaatgt tgtgctaaag cctttagatg aaagcaagtt ctttttagat ttatggcaac
    14761 atccaagctg tttagctaga atgtataaag ttgagttatg gtctgatata cattttgaaa
    14821 tagtcgataa ctatttaaaa gaattagcat ctttaggaga aaaagttgca acagttatag
    14881 tttcagatta tccatgggca gggcaaagtt gttataaagt ttataaaaat ccatcaaact
    14941 tatatgaata taacatggta agtgtatcaa aaggattgga tggaaagatt aaatgtaact
    15001 ttgagagtat ggataggtat ataggcatag ctgataagta taaaatggct aaggagatag
    15061 atttatttgg tctattaggt aattggtgtg ctggtgagtt tggaaatcct gtagaaggtt
    15121 ataaggaccc tataagagta agatattttg atgaaaagga taaagtattt aaatttataa
    15181 acaatacaaa tgatttaaaa gaatatatag gattagtatt aaatcattta atagagtgtg
    15241 gattatggga cagagtaagg attatagctg atgaaccaaa taatccagaa gtagtcaaag
    15301 agtgtataga atttataaat tctactgtag gtactcatca agttaaatat aaatcagcaa
    15361 ctcacgacca aaacttttta gacagagcta aagatgaaat tgatgatatg tcaataaatt
    15421 taaaacttac tatacaaaat tataaagata tagaaagtct taagaaaaaa atcaatgaca
    15481 agggtgggat attgacttgg tttgtatgct gttttccaga aaaaccaaat agttttttaa
    15541 gttctccttt tgtagaaaat agaataatag gatggtatac ttattacttt ggtcttgatg
    15601 gatttttaag atgggactat aatttatgga cagaagaccc ttggaaagat tcaagttaca
    15661 aattccctat ttggaaagct ggagatatgt tctttgttta tcctggaaaa gatttaaagc
    15721 cagttagaag tgtcagaatg gagaatttaa gatttggaat acaggatttt gagttattta
    15781 caatgttaga aaaagaaaag gtaagagagt atatagaagt tgagcttatg caagaattat
    15841 taaataaaaa agaaaatgct gaaattaaag gttttggtga catagaacta ggatattcac
    15901 ttgataattg gagatatgat aaagttaaaa aatatgtatt agagttgtta gacagagtat
    15961 aaaaaatata agagtgtctc aaaatgaact ttttagttca tgaggcactc tttttgtatg
    16021 aaatcaatat agtttcattg tttcaacaat gaaaaatagg attatttcta ttctaagaca
    16081 gccctttagt tttttagttg tattcaatgt tttaaaacta actataaacg ctataaagtt
    16141 tataaatgac aataattata tataacatga tgtactttaa tttgctataa tagggattga
    16201 ataatattat atggaagata acattgtttg gggggattaa tataaaaaga ataggtatta
    16261 ttataatgtt ttttttaagt atatctttta ttggatttta tcttgtaata agagataaca
    16321 gtgatacagt taagatgcaa cgagggataa atataggtaa tgcactagaa tcacctaagg
    16381 attttccgtg ggatgtaaaa atgtcaaata agttttttga tgatataaaa gatgcaggtt
    16441 ttgacacagt acgtatacca gtaaggtttt ctgattatac gtcagattct gataatttta
    16501 aaattgatga agaatttttt aaaaagattg ataaatatgt agattatgca ttggataaag
    16561 acttaatagt tgtgttggat ttacaccatt ttgaagaaat tatgaaagaa ccaagagttc
    16621 ataaagaaaa gtttttaaaa atatggcaac agatagctaa taggtatcaa aaatatgata
    16681 aaaaattggt atttgaatta ttaaatgaac ctaaagaaaa tttatcttca caattactaa
    16741 acgaatacat tgaagaagca ataaagataa ttagaaaaac taaccccaaa agaactatta
    16801 tagtaggacc atataatttc tatcaaattg attatttgaa tgaattaaat attcctaaag
    16861 attctaatat agtagtttct tttcactatt acgagccaaa tgattttgca tttcaaggaa
    16921 atatctatca taagggattt gagcacttaa gcaatattac ttgggaagga acaaatgaac
    16981 aaatggatta tttaaaaaaa aggtttgata ctgtggaaaa ttgggcaaat aaaaataagg
    17041 taaaaatctt cttgggtgaa tttggaataa caaaagaggc accagaagtt tcaagaagag
    17101 catggataaa agctgtaaga gaagaagctg aaaaacgaaa cttttcatgg gcttattggg
    17161 agcttgcatc tggatttggt atatacaatc aaattgaagg gacttgggat agagatatat
    17221 taagtgcatt aatagaaaag aggtgatttt atgaagaaaa attcaaaaaa gatacttata
    17281 actttaacta ttattactaa tgtcatatat atattgtgga gaatttttta cacagtacct
    17341 aaagaagaag ggaagtttgc cttaatatgt gccataatac ttctttttgt agagataatg
    17401 ggtatgatgg aaatgtttgt gcattattat ggtatgtcaa atattgagta tcctgaaaaa
    17461 ccaatcataa gtgaagaact ttatccacat gtagatgtat ttattgcaac atataatgaa
    17521 tctgttgatt tggttagaaa aactgtaaat ggatgtattc atatgcagta tccagataag
    17581 aaaaaggtac atatatacat atgtgatgat ggaaatcgtg aagaaatgcg tattctagca
    17641 gaaaaaatgg gtgtaaatta cataactaga actgaaagag aaggagcaaa agctggaaat
    17701 ttaaataatg caatgcaaca tacaacttct cctttgattg ctacatttga tgcagatatg
    17761 ataccaatgc atgacttttt aattgctaca gtaccatact ttttaaaaaa tgagcaagct
    17821 aaaaaagatg gagaaaaaga ggagtatgaa aaggttggtt ttgtgcaaac tccacagagt
    17881 ttttataatc cagatttgtt ccaatttaat ctgcactctg aaggaaggat tccaaatgag
    17941 caagattatt tttacagaga tattcaattg gctagaaata ggacaaattc tgtaatttat
    18001 ggtggtagta atacagttat ttcaagggaa gcacttgaag aagttgatgg attttatact
    18061 tattctatta cagaagattt tgcaacaggt atcttaattc aaagtaaggg gtatagatgt
    18121 tatgctattc cagaagtaca tgcatcaggt ttatctccta cagatttaaa aagtcttatt
    18181 aagcaacgtg aaagatgggc acgtggatgt atacaaactg gtagacgtct aaatattttg
    18241 tttaggagag gtttaggttt ttggcagaaa ataagttata tttcttcaat tacttattgg
    18301 tatgcaagta taaaacgctt tgtatatata atggcaccta ttttattttc tgtgtttaat
    18361 gtgattgtag taaaatgtac gttacttcaa gtattggtat tttggttgcc aatgtatatt
    18421 ttaagtagtt tatctcttaa aatattttct caaaatataa gaaatactag atggaccaat
    18481 atatatgaaa ctataatgtt tcagtcttta atgccagcag taatacttga aacgtttgca
    18541 atatctaaaa ataaattttc agtaacaaat aagagtaaat tagaagaaaa tagaatgtat
    18601 aagtttttac agggaatacc ttattttatt tacatggtct tatctatcat aggaatttta
    18661 aaaatgtttg tagcaatatt taaaatgagt tcaatgacat attcagttgt attattttgg
    18721 ttgattggaa acctttttaa ccttgttatg gctacattat ttatatcagg gagacagcag
    18781 ttaagaaagt ctgagcgtta tattgctgaa attgatttta agttaaagca aaattcttat
    18841 gttctttctt caaaaacaat tgatatatca gaaaatgggt ttgcattttt gctagaaaat
    18901 ccagaatata tttcaccaga agaagagttt gaggtagagt ttagagaaaa atctggaaat
    18961 gaaatgtata tagccaatat gaaagcaaag attgttaatg ttgtggaagt aaattcaaag
    19021 tggaaatatg cagcttatat tacacatatt gaagatagtg aaatagataa ttggatgtgt
    19081 attgttcacg atagaatacc tactttacca atgacaatat ctaatcaact aggtttcttt
    19141 gatgatttgc aaattaatgt gaaaaaacgt attgaaaaaa ctagaacatt atcacgaaga
    19201 agtccaagaa tcaatatgaa ttttcagatg gatataaaaa atacaggtaa attaagaata
    19261 gtgaatttta attatcaata tgtattatta aattttgaga ataaaagtat ttatcctaaa
    19321 gaaatagcat tggaaattaa tgaaaatatt gtgttagaat gtgatttgtg tgagggtaaa
    19381 attgatgaaa gaggtatctt atataaagta aataacattg acagcataat gcaaaatttc
    19441 tttttaagag atgaaatgat ggattggata ttacaaaata agacaattct tgtttcaaag
    19501 cctagtgaaa agaaggaaaa aagtatagat gagtttgaac ccatggaata tatttaggag
    19561 agatgaaatg aagactttaa aagtgttttt ttgttctaca aaatatctta ttttggtgtt
    19621 tatttttttt ataaatacta cttttataag ttcagcaaca agtgataaaa ttttagattt
    19681 gtcctttaaa aagatagaga ctgacttaaa ttctaagatt acatatgaag atacaggtgt
    19741 aaaaatagaa acggatagtt ctaaaagcga taaggaacgt tatttatata tttaccaaaa
    19801 tataaaagaa aattggagca tgtataataa tttttatatt gaaattcaaa ataaaaataa
    19861 aagttctcag agaataaatt taagcataca aagtaaaaat atgcttgaat ttagattaaa
    19921 agaaggtagt gaagtatttt tagaaggtaa aaatataata tattcagata aaataaaaga
    19981 aggatgcata gaagtaccag gtgaatttga aggcaaaatt tatgtgaact ttaatagcct
    20041 tataaatgag gaaagtaatg ttgtgctgga ctcaaatatg ctttcaaaca ttgttagttg
    20101 gggaattacg tttattccat ctgatgaaga acataatatt gttattataa aaaagatatc
    20161 tttattgtct gaagagaaat taagattttt aaataatatt aaaataattg gcgatgaaga
    20221 agtacaaata ccagtattgg gtcaaagtat aagtcagtat gaagtattag gtcttaaaag
    20281 tgattctaaa attaagtact ctcttatggg aaaacaagat aatgtaagca tatctcaaaa
    20341 aggtaaatta acattaagta ataaagccaa acctggacaa attattttac aagttaatgt
    20401 tgatgataag tttaaaattg gaaagaaaat aacattaact gagtcttgga gtgttaataa
    20461 aaaagataag gatggtgttc catatacatt agtatatcct gagcaatcac caacagtaca
    20521 agatatgaaa aaaataaact ttatgaataa catcataacg tttgttcgaa ttttatttgt
    20581 atctctagta ataatatgct ttggaatata tttatattgg aaaaaatgtt caaaaactaa
    20641 gtaaagagag gaggttagat tgtgttattt tcaagtttaa tttttttatt ttatttttta
    20701 cctataactt tggttttata ttatgtattt aggtttaacc gaacgataca gaacatgata
    20761 ttgcttgctg ttagtttatt tttttatgct tggggagagc caaaatttgt tgttatcatg
    20821 atagtttcca taataatgaa ctatatattt ggtttactgg tagatagata tagggaaagt
    20881 aaaataaaag taaaagtttt tttagttttg atgtgtgcat acaatatagg tgttttattt
    20941 atatttaaat atctagcttt tgcgctaaga aatattagtg aacttattag tactgaattg
    21001 actataccta gtattgtttt acccatagga atttcatttt ttacatttca gggaatgtct
    21061 tatgttatag atgtatatcg tagacatgga gaagtccaaa agaacccttt ttatgtggga
    21121 ttgtatatag catttttccc acaattaata gcaggtccta tagttagata tgagagtgtg
    21181 gcagaacaaa ttctcaatag aaaagaaact tggaataaat tttctattgg gacttgtagg
    21241 tttataacag gtctaggtaa aaaagtatta atttcaaata acatggctat agtagcagac
    21301 tatatttaca ctatgaatag tcaaggagaa atagctgcat cacttgcatg gcttggttca
    21361 atagcctata ctctgcaaat attctttgat ttttctgctt attcagatat ggctataggc
    21421 ttaggtctta tgtttggttt taaatttgaa gagaacttta attatccata tatatcaaaa
    21481 tcaattagtg agttttggag aagatggcac atttctttgg gaatgtggtt taagagctat
    21541 atatactttc cgcttggagg ttctagagta gcaaataaag atattatgat tagaaatatg
    21601 tttatagtgt ggttatttac tggaatatgg catggagcag aatggacatt tgtaatttgg
    21661 gggattttaa actttgtttt cctaattata gagcgattta taatgtttga aaagattgaa
    21721 aatcacaatt ttataaaaca tatttatgct ttattagtag ttaattttgg gtgggtatta
    21781 tttaggtcac ctaatttaaa agaagcatat aattatttta aagctatgtt tggaggcaat
    21841 ggagctatat ggagtgatta tacatatatg tttttaaaag aatactgggt tttctttata
    21901 tttgcattta tttttagtgt acctattgca aagaaaatca ataagtttgt tgttgaacaa
    21961 gctaaatata gtatgatatt taacgtattt tatccaatct cagctatttt attgtttttt
    22021 atttctgtga catatttagt aactggaagc tataatccat ttatttattt taatttttag
    22081 ttgggaggaa aagtatgaat agatttttta aagtaagatt aataactgca attatgttct
    22141 taattatttt attcgctttc tctatcttta atgtttgtta ttctggaaaa gatacgatac
    22201 aggaaataaa aaattcaata gctgaaaaaa gtagtttaaa agatacaata tcatctattg
    22261 ataatacagt gaatgacaaa gtaatataca aaaatacgtt cattgaaact tatggctatt
    22321 tacaaaaatt aatgggtaaa aatgagtttt caaaatttag tgttgtaaaa gatacttctg
    22381 gaaagatgca ttatacatat tttgctaaag ctccaaatcc agttggtgtg atagcagata
    22441 gggtaagaaa attttctgat gaaatggaaa agcaaaacac taaattggtt tacctaatga
    22501 ctccagataa gtatataaaa ggagtgacaa aatttccaaa aggaatacct tattcttata
    22561 gtaatgagac agcagataat tttttaaatc aactaaaaaa gtataatgtg gactatattg
    22621 attttagaga aaatatttta aagagtggta ttccaaaaga tgatttattt tttaaaacag
    22681 accatcactg gaaagtagaa acttcttttt gggcatttgg agaattagtt gagcaactta
    22741 ataaaaaata caatatgaat ttagatgaaa atcattatta tagagataag gacaattata
    22801 attcaattgt atatcctaag tcatttcttg gttctatggg aagaaagact ggtatcttat
    22861 atggtggtat agatgatttt acattaattt atcctaaatt taagactaat tatacttatt
    22921 atacagattc taaatctcaa aaatttgaat taaaaggaag gtttgaagag agtttaatat
    22981 tatcatatcc ttttaatgca gaccttgatt taatggatgg tcaatcagat aagtatttta
    23041 catatttatt ggggaacaga ccattagtta aaataaaaaa tatagaaaat ccagatggat
    23101 taaaagtgct gtttgttaaa gattctctaa ttgtaccaac agcagcattt ttttcctctg
    23161 tttgttcatc tatagatatg atagacccta gatattatga tggagatata ctagaatatg
    23221 caaaatccca tgactatgac tttgttttta tatctgtata tccccaaaat cttacaaaag
    23281 aattttttcc gttttgtgag taaatttcta aaaaagtttt ctgataaaat aaatggctaa
    23341 ctggtaaaaa gttagccatt tattttgagt gttattctaa gaaatatttt ttttactaaa
    23401 tacttcttta tctatttttc caagtgattt tcctacagta attgatgata ccatagcacc
    23461 attaacattt atcatagtac gtcccatatc tagtataggg tctattgcaa gtataccacc
    23521 aactaatgga aaataagaac caagaccaac tccagagata acaactgaaa cggccattgt
    23581 agcagttcct ggaagaccag ctattccaaa cgaactaatt gttataacaa ttaacaacat
    23641 aacataaaag ctcatatcca tgtttactcc agccatattg gcaagtgtta cagccattaa
    23701 agcaggatat atacctgcac aaccattcat acccatattt gcacctaaac ttgctgtaaa
    23761 gcttgataca ccctcatcaa ctccgtgatt ttgtactaga ctttctatcg ttacaggcaa
    23821 tgttcctaaa ctagaacgtg aagtaaatgc cagaagtaaa gcttcagttg aattttttat
    23881 ataagtaatg ggatttagac catttaaagt tataaaaatt aaatgtataa taaataatat
    23941 tgcaactgat atataaagag ctaatataaa ctgtaaaaca gatactattg aactaatacc
    24001 ttgtgaagtt attgtatttg caagcagagc aaccacagca taaggcataa atttaataac
    24061 agtcatagac acacttacaa ttattttgta agatgcttct ataaaaccta taaatggttt
    24121 tattgtttca aaatgttttt tacttaatct ctttattgag gtagctataa atgtagcaaa
    24181 tattattgta gctacaatat ttccatttgc catagccatt acaggattag atggtagtaa
    24241 tcctcttaaa gtatccacaa gagagtttat ttctttaagt tcttgatttt caactaaagt
    24301 aggcatatta gctcctacac ctaacttcat tatatttgca acgataattc caacaattgc
    24361 agctatagca gtagtagcaa gaagcatacc taaagattta aatgtcagag ttccaagatt
    24421 gttatctttc atatttataa ttacttttat aatggataag aaaactaaag gtactactaa
    24481 catttttaat aagtccataa atccagaacc aaataggcta taccacttac ttacttcttg
    24541 tagccaaatg acttgagttg tatcattagg aaaaccagca aaagcttgta ttatgattcc
    24601 caatatgagt cctagtactg tagcatatat tgttctcaat gaaaatttta tttttttctt
    24661 ttcaaattgt ctaacaataa agaacgtacc tagaagtaat attatgaaaa aaattgtttt
    24721 aaaatctgta atcataagaa attgtgataa aaatgaactt tccaatattt ttctcctttt
    24781 atttaaaaat aaatttttct aagtttaaat gatatcaata tattaaaaaa atgtcaatat
    24841 tatatcacaa tttacttaaa tagagtaaaa caagttgatt ttgaaaaatg tgattaagta
    24901 cagaaaaata gggtataata aatgtttaaa gaatttgaat tgtggtaaga aaataaaaaa
    24961 tagcttttat aagatttgat ttcaaattaa aatgtgttaa ataaataact aaaaattatt
    25021 ataaaaaatg ttttcataga atatatatca aatgaaaagc ttaaaataag tgaagaaatt
    25081 aactagacat caaaggagag ataaaatgag agtaataata attggtggtg ttgcagctgg
    25141 tatgagtgct gcagcaaaat taaaaagaat aaaacctgag tatgaagttg ttgtttatga
    25201 aaaaactgaa atagtatctt ttggtgcttg tggattacca tactttgttg gtggattttt
    25261 taatgatgct gatgaattat tagcaagaac accagagaaa cttagagaag ctggaattga
    25321 tttaaatata tttagagaag tcgttgaggt tgatagtgaa tctaagaaaa taaaagtaaa
    25381 aaacataaaa acagatgaaa tatatgaaga ttactatgat aaattgatga tagcaactgg
    25441 agcaagaagt attatgcctc ctataaaaaa cataaaatta aagaatgttt ctacattaaa
    25501 aagtttatat gatggagaat atttaaaaaa acttttaagt aatgaagata ataaaagagt
    25561 gacaataata ggagctggtt ttatagggtt agaagcagtt gaggcatgta agaaattagg
    25621 taaagatgta gatgtaattc agttagaaga tagaatattg ccacaagtat ttgataagga
    25681 aatgacggat gtattagaag aagaaataaa tagacataat gttaatttgc acttagatga
    25741 aatggttgta gaactttgtg gagaagataa agtagaaaaa gttataacaa acaaagggga
    25801 aatagataca gatgtagtaa taattgctac tggcgtgaga cctaataccg agtttttgtc
    25861 aaatactaat ataaaaatgc taaaaaatgg agctatagta gttgatgagt atggaagaac
    25921 ttctgtagaa gatatatact ctgctggaga ttgtgcaact ataaagaata tagtaagtaa
    25981 tgaaaatgta tatgttcctt tagctactgg agctaataaa ttgggtagga tagtaggaga
    26041 aaacctagca ggaagagaaa tatcttatca aggttcacta tcttcaagct gtataaaaat
    26101 tatggatatg gaggcagcat caactggaat tacagaaagg caagctaaag atttaggcat
    26161 aaatgtcaaa tctaaattta tttctgatta taatcaaact cattattatc caggaagaaa
    26221 taaaatatat gtaaagctta tttatgatgc agatacaaaa gttattttag gcggacaagt
    26281 ggctgggttt aaggatgctg tccaaagagc aaatgtattg gcagctgcta tctttggaaa
    26341 aatgaccaca aatcaacttg gaatgttaga tttatgttat gctccaccat ttgcaagaac
    26401 atgggatgtt ttaaatgtag ctggaaatgt atctaaataa tatttagatt atagctaata
    26461 tagttgacaa gcaattaagg gaatgaattt acctaaacta tttttatcat ggtaaaattc
    26521 attcctaaat ttttattcca aatttttatt ccaaattttt agaaataagg attccattaa
    26581 attattcatc aaaatttaaa cgcaagctta atctatcttc tccaagaata gtattttcaa
    26641 aaacattagt agcattttct aaatacatac taggtatgtc taaagaagga ctaaaatgag
    26701 tcagtaaaag ttgtttgaca tttccaagtt ttgcaagatt agcagcttct ctaaaagtca
    26761 tatgtttgtt tctaacagct tttgatatat ctaaatcatc accatacatg gcttcacata
    26821 taaataaatc actatctttt atgaaatctg gtattgattc tataggtctt gtatcggttg
    26881 taagacttat cttaactccc tttctcaatt ctcctaagac catatctgga gtgtattgtt
    26941 ttgaatctaa aactatattt tgaccttctt ggagtttgtt ccataatatt ttaggaactt
    27001 cgtttttagt tgccttatct atatcaaatt tagggtttct tctaaaatta aaactgtatc
    27061 ctaaacactc tatagagtgt tctaaactga ttgttgaaat ttctaaattt cttaaaactt
    27121 tattatctaa agaaaaattg ccttgagggt tttctataat ttttaaagtg tatggtacat
    27181 attctactaa atttctcata gaacgtatac aatcgactat tccaactgga ccaactatag
    27241 ttaaatcact tgtacgacca ctattcccaa ttgttgataa aagtcctaaa agtccaaata
    27301 tatggtcacc atgtaaatgg gttatacaaa tcaagtctat atctttaaag ccacattttt
    27361 ttagcttcat agatacctga gtaccttcac cacagtcaat tagtattttt ctacctttat
    27421 agtttataaa tacagaggat agaaatctgt ttggcatagg tacatttcca ccacatccaa
    27481 gtaaagttaa atctatcatt ttttcccctt tctaaaatta acacaaatct gttgtttgtt
    27541 tttattatga tatcctatta taattatttt aacattaaat ataacaataa atgtgtattt
    27601 gagtcaagaa atattgtcaa ataaagtttt tatatagcaa tgtataaaaa tttggaaaac
    27661 gaaaagtgaa aattatattt aggagtattt aaaggaggaa aatttaatga aagtattaaa
    27721 gaaaattact attttgtcat taattacatt aaccttagtt ggttgtagta acggagaaga
    27781 gaaaaaagtg gttgaaggtt ctaagaaaac tcaaaattct aaaaaagatg aacagcctat
    27841 aatagtacat aaagatgcaa atatattgaa agataggtat gagccaccaa aaggatttaa
    27901 aagagttgat gtagaaaaag gtagttttga atcatttctt aggaatacta agctaaaaaa
    27961 ttatggagag aaagtaaagt attatgatgg aagaactaag gaatcaaaag gtatttatga
    28021 tagtgtattt gatgttgata ttggaaatag agatttacat caatgtgcag atgcaattat
    28081 gcttatgaga gcagaatact tgtatcagaa taaactatat gatgaaataa gttttgattt
    28141 tgttgatggt tttaaggcga agtattcaaa atgggcacaa ggatatagaa tttcagtaaa
    28201 agatagtggt tcaagctggt ataaagcaac tgaatattca acatcttatg agagtttcag
    28261 aaagtttatg gatatagtgt ttgcatattc aggaacgtta tctcttgaaa aagaattgga
    28321 gcctgtaaaa gttgaggata tgaaaatagg agatgtgttt atagttggtg gaagtccagg
    28381 acatgcaagt ataattatgg atatggcaga aaatgaaaag actggtgaaa aggtatttat
    28441 gatagcccaa agctatatgc ctgcacaaca aacgcaactt cttattaatc gtaaaaatcc
    28501 aaatttgagt ccttggtata gtttagattt tgaaggtgat ttgacaatac ctcaatggac
    28561 ttttaaaaga gaccagttga aaagatttta aaataataat tttatataat aaaagaaaaa
    28621 tatagatgtg aaaaaatgta attagattaa aactaattgg atatggacaa aattaaattg
    28681 atagataaat attaaaaatt acactaatta atcttactat agtttaatat ttatctaaaa
    28741 agttttatgt aaaatataaa ttttatatta aagctaaaac taatttgagg aggctaattt
    28801 atattgaaga ttagaaggta tttaattttg gtaattataa ttctaattac aacaagtcag
    28861 agttttattt cttatgggct agagcgattt gaagaaataa ccatttttca cactaatgat
    28921 atacatggaa gatatgctga aggtgatgac catatacaaa taggaaatct agccacattg
    28981 aaaaaagaaa ctccaaactc aattttagta gatgcaggag attgtttgca tggacttcca
    29041 atagtaaata tggatagagg gaaaagtgca attgaattaa ttaaatgtgc tggatatgac
    29101 tatattactc ctggaaatca tgactttaat tatggaaaag atagactgtt tgagttatct
    29161 aaaagtgcta atttaggaga gaatacttta aaatttttat catcaaatat ttttgaaaat
    29221 gggaaaaaag tttttgatag taatgatata aaagaaatag atggaataaa aataggattt
    29281 tttggactct caacccagga aacaaagagc aaaactggat ttaaaaatgt ggaaggatta
    29341 gagtttaaaa atcctataga aagtgcaaca gaacaagtaa atgaattaaa aggaaagggt
    29401 gccaatgtaa tagttgcaat atgtcatatt ggtacaaata gtttaagtaa gccaaatagt
    29461 atagatatag caaatgaggt tcaaggaatt gatttgatta ttgatggaca cagccacact
    29521 aagtttgaaa atggtaaaca agtgggtgat acattgattg taagtgcagg acaatattta
    29581 gaaaatattg gcgagataaa actaactttg gatactaatg atgtagaaga tataaaaata
    29641 gaaaataaat cagctagatt aattggaaaa gaagaagcat taaagtataa gcttgactcc
    29701 gttgtaagta aaaaggttga taaaataaaa gaacaacaag aaaaaatatt agataaagtt
    29761 ataggggtaa ctacaaatac tctagatggt tcatatgaaa atgtaaggac aaaagaaact
    29821 aatttgggta atttaataag tgacatttta ctagataaaa ctaaggctga tatttcttta
    29881 tttaatggag ggaatattcg agatacgata gaaaaaggca atataacaag aagagatatt
    29941 gtagatgtat ttccttttag caatactata gttaccaaag aacttacagg agcacagatt
    30001 aaagatgtat tggagcatgg agtaaaactt tatccagaaa aaagttcagc ctttttgcaa
    30061 gtgggaggaa tttcatatta ctttaatcct aaacaaaaag aaggcgaaaa aataacaaat
    30121 attcaaaaag aaggaaagcc attagattta aataaaaagt atgtagttgc aacgaatgat
    30181 tatatagcat caggtggaga tgaatttcct tgtttttcaa aagagccagt actaaaggaa
    30241 tttggaaatt tagagagtgc agtcattgaa tatatagagt acaaaaaaga aatatcaaaa
    30301 aatgtagatg gaagaattgg tattaaatct aaagatgagt taataagcaa gaatcatgag
    30361 agtgatttga tattaagtga aaatgaaaaa aatatcaatg ataatgaaga gaatctatct
    30421 aataatataa aaagctctga tagtgataaa aataaaagct tagataaaac aagttctaga
    30481 gaaagttcta atctaggaat atctaaaaga gaagctaaag aaaaatctcc taaaacagga
    30541 gatttaggtt tttcaaatag tataattata tttatagttt caagtacatt gatatgttta
    30601 ttgaatttta atcaaaaaga gttaaaggat aaaaagtcaa aataaaaatt aatgagcaaa
    30661 aattagtaga tagtaattta attttagata atagtaaaca gcaaaggaaa ttagttatat
    30721 aaatactaat ttcctttgtt ttatgtttta acatgattac ttttaaataa aattgtattt
    30781 tatgaaaaat aattatacta aatggcatag tattatgggg atttttagtt tttattcaag
    30841 taaatgaaat catattaaca acttctgata tatttacaaa ttgataaaaa aatgatttta
    30901 ttagtatgat ataatttagc tagtatgtat gataatggag gatataggga tgaataatat
    30961 attacttttg gaagatgaca aatctttaaa tagaggaatt agttttaaat taaaaaaaga
    31021 aggatacaat gtttttagtg catttggtat agaagaagca aaaaatattt tcgcaaaaga
    31081 agagatatgc ttaattattt ccgatatagg tctacctgat ggtagtggtt ttgacttttg
    31141 tgaggagatt agaaagaaaa gtgatgttta cataataatg ttgacagctc ttgatgaaga
    31201 ggtggatatt gtcacaggat atgatttagg tgcagatgat tatatcacaa agccttttag
    31261 cttgatggta ttaatatcaa aagtgaatgc gcttatgaaa agagtaaata cagtaaaaaa
    31321 ttatactcta ttagtttgtg atgatttatt cttttattat atagaaaata aattaattat
    31381 aagaacagat gataaggaag aagagataat tttaagtaag acagagacaa aactattaaa
    31441 atatttgatg gaaaattcta tgcagacatt gactaaagag caactgttag aatctttatg
    31501 ggatagtagt ggtaattttg tagatgataa tacgattgca gtaaatataa gaagacttag
    31561 acaaaaggtt gaaaaaaatc catctgaacc taaatatata aaaacagtaa gaggggttgg
    31621 atatatgtgg ggagaaagga gtataaaaaa atgctaaaaa atatgaacct caaagatggt
    31681 ttaagtgtga aagatgatta tataatgaga agagttattg tatattctgt tttatctgta
    31741 ctaatagtaa cccttgtatt tatacttttt gaatatagca gattacataa attgtatgaa
    31801 catcaaataa aaaatactca aaatgttgct ggaatattga ttgaaaaata tcctaatgat
    31861 gaaatagata tagtaaattc tatttataat tctgattata gtaaggtgtc tactggagaa
    31921 aaggcattta agaaatttgg ctatggattg gaaaataaaa tgtcaaatga taaaaatttt
    31981 agcttatact taaaatcttt ttttaaggaa tcatttttta tttttttaat gatgtttata
//
LOCUS       DAEHWM010000039        31571 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.040, whole genome shotgun sequence.
ACCESSION   DAEHWM010000039 DAEHWM010000000
VERSION     DAEHWM010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 31571)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31571)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31571
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.040"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            129..671
                     /locus_tag="KNP36_001891"
     CDS             129..671
                     /locus_tag="KNP36_001891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0873765.1"
                     /translation="MKICITVGHSILKGGKSTGVNGIVDEYNYNKKLAPMLAEMLISQ
                     GNTVDVIICPERHFMSEREEFFYRVPKVNSGKYDLLVELHLNKADGTQCGTEVLYYGT
                     EGLEYAKRVSNRLGELFENRGAKKRENLYILRNTNPVAIQIESFFCDNVNDCNKANES
                     GYDYIARLITEGILNKDINM"
     gene            999..2492
                     /locus_tag="KNP36_001892"
     CDS             999..2492
                     /locus_tag="KNP36_001892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBF0873766.1"
                     /translation="MKYTFEKFKLNEKILKSLKSLGYNIPSRVQREVIPKLLKGQNLV
                     VRSKTGSGKTASFAIPLCENINVDYNNIQALIVVPTRELALQVKDEISDIGRLKKVRC
                     SAIFGKQSIKDQIAELKQRVHIVVATPGRILDHINRGSIKLENVKYLVIDEADKMFNK
                     GFVEQMEKILLNLPKEKIVSLFSATIDEEIKYICEKYMLDYSVINIEENESDTNQKTR
                     QIDDKIIKANGREKYILLKELIYSENPKSVIIFCNTKEKVSKLYNKMSKEGFLIRELH
                     ADLSQERRIFVIKDFKNQKFNILVSSDVASRGIHIDDISLVINYDVPQDKENYIHRIG
                     RTGRKGNSGKAITIVTEKDEKYIENIETYIGYKINELKDIEKSRITHGKVLFEEYSKG
                     ILKKVSKRKKVDKNSYKSKDIKLNIESEVVKLYLNAGKKKKIRVLDIVGAFSNIKGIT
                     NDDIGVIEVQDLCSYVDILNYKGDLILKKYKEIPIKKKMVKVKRDIR"
     gene            2566..2799
                     /locus_tag="KNP36_001893"
     CDS             2566..2799
                     /locus_tag="KNP36_001893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873767.1"
                     /translation="MKAEDMKRKVSPIDLERILVTGGVIKHEDSIWLLDFWGNKDIAG
                     ILLMPPTRHVILHLNDCCKWKEYFRTKKKFYRS"
     gene            2955..3719
                     /locus_tag="KNP36_001894"
     CDS             2955..3719
                     /locus_tag="KNP36_001894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0873768.1"
                     /translation="MAYFNYNDKQCYYNEIGDGTPLLFLHGNTASSKMFNDIINFYKD
                     EYKVILIDFVGHGKSQMVDKFSADLWFDEAMQVICFLEAMNYKKVNIIGSSGGALVAL
                     NVALERPDLVNKVIADSFEGEVPLESFVQNVKIEREASKQDDGAKAFYIYNQGENWEK
                     VVDNDTEAIFEHYKTIGKFFHKPLETMQPEVLLTGSREDEFVSLISSDFFENTFSLLL
                     EKIKNGKMYLFDKGGHPAILSNGLDFSNVAKKFLEE"
     gene            complement(4004..7183)
                     /locus_tag="KNP36_001895"
     CDS             complement(4004..7183)
                     /locus_tag="KNP36_001895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBF0873769.1"
                     /translation="MKIDMIYKLIRRNTEPSRWSRGVKYYTNQLVDYIDIDIDDLQNN
                     LLTFRGGVNSEDNYSFYFNSITIDIKHFKIIENDCSCADCQSKGKSIFICKHIVAIVI
                     KSLKQIKNKKDVPPILIDILGADKDKLSNTNSKTSLDLSKQLLSLLDNTKRERVNLDV
                     LINVDSNKAIAEFKIGINKMYILKNITEFAYSKLNGYELDFGKKFTYNPNTHYFADED
                     EKLVDIIEEYGTNLSYNFSSSHSKKFMEINASSLKQFLNAIKYKDFTLIFSKEEYHPK
                     ILNDTLPVRFDFKNIEDKIVLYSKDSLPVPLTKKNDVLLYDGNIYLLSHKKAHDYSKI
                     YQILSKTKELKFDKEDSKDVLGLLVPRLKSISQEVHLDDNIKNNITKDFKSEFYFDMI
                     DGNICCDVKYIYDDEDKKFVLPNIQKEATIENKLTSSQFTKENNHYVFKGTDHDLFTF
                     LDLQLESLKEFGDIYYSEKFKLKKIYNASSIQASINQTNQNYLEFNFNISDINPKEYK
                     DILKAFQEKRTFYKLKDGNFIDLSERETKDFFELVENLDIMDKSKNNKIHKNKALYIN
                     DVIRSKNLKFIDGKKELDSICEKFRNFDSINLEIPANLNANLRDYQINGLNWFKVLDY
                     YKFGGILADEMGLGKTIQTIAFLLSLSNKKSLIVTPTSLIYNWKNEFEKFAPDIKVLL
                     IHGNKRDREKCFMELENFDVILTTYGTLRNDLDKYSEIKFDYCILDEAQNIKNPVALV
                     TESVKSINAENKFALTGTPMENNLLELWSIFDFIMPGYLYSKAKFQELFINKEDNVKN
                     LKKLIKPFILRRSKKQVMKELPDKIEKNFFVELNKEQKKIYSVYSKDIQDKMKDKNLK
                     KDKIVIFSYLTKLRQLCLDPSIVVKDYNKKSSKIETCLEILRDSINENHKILLFSQFT
                     SVLKNISKELDKYKIKYHYIDGKTNAKERLELVDEFNNSMDKKVFLISLKAGGTGLNL
                     TSADMVIHFDPWWNPSVENQASDRAHRFGQKNSVQVIKLIAKGTIEEKIIKLQESKKE
                     LINQFINGELSNEGVLKSLSDEEIINLFN"
     gene            7464..9641
                     /locus_tag="KNP36_001896"
     CDS             7464..9641
                     /locus_tag="KNP36_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBF0873770.1"
                     /translation="MYNKYNNLYLLLGKENVNMDSYKQLKAKIPCKETGIEIKRTLCD
                     ICSPGVHCGIDAYVKDGKVIKIEGTKEHPMNKGLLCTKGLCNREYIYREDRIKTPLKR
                     IGKRGEGKFKPISWDEAYREIAEKLNRVKSEYGAKHVAFFTGYGKWYRPFLQRFASSF
                     GSPNYGTESSSCSTSAQMAGNVATGRNFTMQDMENAKTYLGWGFNPYYSKFLNSVNLI
                     KLKEKGLKFIIVDPRITPTTQKLADLHLRIKPGTDGALALGMANLFIQKDLIDREYIE
                     KHVHGFNEYKEYVKLFDLDTVSRITGVSKDNIVKAVEMLSQGPFCINESAAPIVHHQN
                     GFQNYRAMMSLSAITGNYDRIGGNIPKQDYFAGKIGGFQTLEKEFVKEVLPKNINERI
                     GGERFPLWNEMVTQFQAMDLPRQIEEKTPYEIRALFCHGINARMFPNSGRLFKALNSV
                     DFFVNIDLFMTDTSKYADILLPACTSFEREECKSYPGGYITYTKKVIDKLYDSKSDVE
                     ILSDLANAMNIDDDLLKAGYEASVRHMFKNTCVDVDKLKESDLPLKCKDFKPYIVGSY
                     TREGYDTSTSRFELKSTIIEKYKDFGLDALPTYRGFNDNIDDEYTHLLTSGARISNAL
                     HSRLHDIKLSRILKNEANCDISSLDAKELGVISGDYIKITTKIGSLDVKVNVTDRVLY
                     KNIHMYHGYREADINSIICDNFDPYSGFPAYRSCKCKIEKMNR"
     gene            9655..10077
                     /locus_tag="KNP36_001897"
     CDS             9655..10077
                     /locus_tag="KNP36_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0873771.1"
                     /translation="MKSLFKFNKELCTACGACLLACIDQNDNNIDNGELFRHVFTIEE
                     GENIEYFSLACIHCNEPKCLGVCPKNCFKKEEGFIVLDNQNCIGCKLCEKACEYGALI
                     YGNDGKANKCNGCIERYKCGMDSPCVMVCPTGALKFNK"
     gene            10251..10826
                     /locus_tag="KNP36_001898"
     CDS             10251..10826
                     /locus_tag="KNP36_001898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0873772.1"
                     /translation="MVKVLAFMGSPRKKGNVDTILDEIIKGVNDNNVEVKKYYLNDMN
                     IKGCQGCLYCRKVPTCAFKDDMIDIYEDIKSAEYIIIGSPVYICQVSAQTKLLLDRLY
                     PLTEINKSKHIPRFGQKKLIMVYTQAAPISFLFKKYFKYTAKHLKGMGLNHYKTIVVT
                     KAFERNSTKKNFKVLKKAYKLGMKIAIDING"
     gene            complement(10951..11667)
                     /locus_tag="KNP36_001899"
     CDS             complement(10951..11667)
                     /locus_tag="KNP36_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBF0873773.1"
                     /translation="MQQGSDYLKKFLEKHIDLLKKIPLFEGIKSDELEEMLECLGVVD
                     KTYPKDSIIFSVGSEVTSIGIMLKGSAHIIKEDIEGNRNIVAELLPGDLFGEVFACTR
                     LHKSNVTVTTTSSCEVLFIKFKSVTGICSSACVFHNRLVENMLQLIAEKNILLHNKIE
                     LLSRKTTREKLLMYFSKQIEQTGSHQFTIPFSRNEMADFLCVDRSSMSRELGKMRDEG
                     LLSFNKNKFEIFYFQNKLDI"
     gene            11832..12557
                     /locus_tag="KNP36_001900"
     CDS             11832..12557
                     /locus_tag="KNP36_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0873774.1"
                     /translation="MMRKIIKIDEEKCNGCGLCVEACHEEAIGMVNGKAKLLRDDYCD
                     GLGDCLPTCPTNAISFEYREAAEYDEAAVKANMEAKKAQKKTLACGCPGSQSKSINRE
                     VSNSTSISNDIVEIKGSQLNQWPVQIKLVPTNASYLKNASFLIAADCTAYAYGNFHNK
                     FMKNKVTLIGCPKLDEVDYAEKLTEILKENDIKNIVVTRMEVPCCGGIVNAVKTALQN
                     SGKMIPWQIVTISVDGKIVDGEI"
     gene            12617..14209
                     /gene="hcp"
                     /locus_tag="KNP36_001901"
                     /gene_synonym="priS"
     CDS             12617..14209
                     /gene="hcp"
                     /locus_tag="KNP36_001901"
                     /gene_synonym="priS"
                     /EC_number="1.7.99.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxylamine reductase"
                     /protein_id="HBF0873775.1"
                     /translation="MEKMFCFQCEQTAGGKGCTINGVCGKKGGTANLQDELTGVLIGL
                     SRATIGNKNRPTSETDKIMIEGLFTTITNVSFDDEAIKRQIEKTEVEKSKLVPRCSDC
                     STTCNRNDNYDMKDLWNDNEDIRSLKSLILFGLRGMAAYAYHAMVLGYTDKDVNEFFY
                     EGLIAVGGDLSIDELLGLVMKTGEINLKCMELLDRANTETYGTPEPTQVSMKIEKGPF
                     IVVTGHDLYDLHKLLEQTKDKGINIYTHGELLPAHAYPKLKEYKHLKGNFGTAWQNQQ
                     KEFDNIPAPILFTTNCLMPVKDSYRDRVFTTEVVAYPGMVHIDEDKDFSSVIEKALEL
                     GGYREDVHMTGINGGDTLTTGFARGTVSSVQDKVVDAVKSGAIRHFLLVGGCDGAKPG
                     RNYYTEFVKQAPKDTVILTLACGKYRFNDLDLGDIGGLPRLMDMGQCNDAYSAIKVAV
                     SLANAFECGVNDLPLSMVLSWYEQKAVCILLTLLHLGIKNIYIGPSLPAFLSKNVLDI
                     LVDKFALTPISTPEEDMKKILG"
     gene            14581..15486
                     /locus_tag="KNP36_001902"
     CDS             14581..15486
                     /locus_tag="KNP36_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBF0873776.1"
                     /translation="MKNSNFNILAFDGGGLKGALSISILERIVKEYPNLLNNINMFGG
                     TSTGSLIALGLAYGVSPKEIKELYSIENSKYIFNKSYAEILRPKYENKNLKEVLLSIF
                     PEELELKDLNKLVMIPSFYIGNEENAWKPVFYNNMPNSFTKTSKVVDVAMASSAAPVF
                     FPTYNRHVDGGIIATDPSLACIIHAIDSGFKLKNTRLFSIGTGYVYNSIKADTTEWGA
                     IDWIINKEPDLPIISITLEGNSQMSQLFSQKLLGDNYYRLNPKMEKDVAMDDCDALEY
                     LMSLGENCDIKDAFGWIKKKSFYRN"
     gene            15610..16563
                     /gene="msrA"
                     /locus_tag="KNP36_001903"
     CDS             15610..16563
                     /gene="msrA"
                     /locus_tag="KNP36_001903"
                     /EC_number="1.8.4.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="HBF0873777.1"
                     /translation="MIKLATFSGGCFWCMVKPFDKYDGVIKVVSGYTGGHVENPTYQE
                     VCSGTTGHLEAIQITYDDDIISYDELLNIFWKQINPTDDGGQFGDRGTQYKTAIFYHD
                     EEQKNIALESREHLENSKIFDSKIVTDIIPATKFYEAEENHQDYYKKRPLNYNMYYKG
                     SGRYNFVKSHWDGNNINREELKKTLTPIQFEVTQNDMTEVPFENEYYDNNKEGIYVDI
                     VSGEVLFSSKDKFDSGCGWPSFSKPVIDKSIIERSDFSQGMYRVEVRSAKGNSHLGHV
                     FDDGPKELGGLRYCINSASLKFIPRENMEALGYGEYLKLFE"
     gene            16716..17846
                     /locus_tag="KNP36_001904"
     CDS             16716..17846
                     /locus_tag="KNP36_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0873778.1"
                     /translation="MNLKDFNGKRLKSARIFRAKTIEQLSKETKINKKDLKAFEENKY
                     VPNIENTLKLSNILNFPKEYFYKNENINIVVEDSHFNPQSKLPRVEEISYREKIIIIH
                     KIYSFMENYIKFPKENLPNRKVMSDININDIESLAYKTREFWDLNSTPIVNMVSLLES
                     KGIIISGMNVDRKGATIFTQKQRISKESKYLISLGNDKKSASIRNYTLACELGYIISS
                     ELRIPSKQFSEDEYACAFLLPKESFLKDLTHPEDLDYYVELKKKWIVPISAMIFRAYN
                     LEKINYKKYNYLMNEMDKKGWLIEEPLDKMKGSSPTYLKRAVELLIENKIMSVNSIVS
                     SLEEFGINLYPEDLELLMGLKKGLLSQEVNKKSKVIKFDGKK"
     gene            complement(17963..18931)
                     /locus_tag="KNP36_001905"
     CDS             complement(17963..18931)
                     /locus_tag="KNP36_001905"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HBF0873779.1"
                     /translation="MAIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSK
                     AQALDLADAVSYLPHKVHIEKGTFSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRP
                     TIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRL
                     RRILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDMIKDNPSTYSNLDLP
                     SIVEKNKKTGISIINGKDCTEFGIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNV
                     FAGVPCVIGKDGIEEIIEINMTEYEQNEFNKSCSVLREYIALSKTL"
     gene            19266..19454
                     /locus_tag="KNP36_001906"
     CDS             19266..19454
                     /locus_tag="KNP36_001906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873780.1"
                     /translation="MNYHTKEELVEALRVVSSSIINCGKGQKKFSEETSHHTRFKNII
                     EVMYISKSLIMDEISKRD"
     gene            19714..20913
                     /locus_tag="KNP36_001907"
     CDS             19714..20913
                     /locus_tag="KNP36_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanyl-tRNA editing protein AlaX-L"
                     /protein_id="HBF0873781.1"
                     /translation="MEKLYYTNQYIRDFTAEIIEIKEVENKYHVLLDKTAFFPGGGGQ
                     FGDLGKIENDDVINVYEDGKKIYHVLDKKPIKIHKVKCSIDWDRREDGMHQHFGQHVL
                     SGCFFKTFNANTTGFHLGNEYSTVDIEGNLEEDKIREIELFANEIIRQNIQVETLLPT
                     KKELKKIWLRRDLPNTDEEIRVIKIGDLDTNACCGVHPKSTGELRMIKIKKWEKHKSS
                     TRIEFLAGKRAVDEVLKRDIYLTKICRYLSCSEEDAINGIVNLNSKVEEALIKKRRLE
                     EVVSTYQVKEMIEKANKVGNISVIKKIYDDEDLKYVNKIANKIAEYENSIALLAVKFN
                     DKINLVFACSKNLKDINMGVLLKDAINLIDGKGGGSKVLAQGGGKNNGNLEATLDYAF
                     MKIEKTL"
     gene            20965..21468
                     /locus_tag="KNP36_001908"
     CDS             20965..21468
                     /locus_tag="KNP36_001908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0873782.1"
                     /translation="MEQQKDYIELYENEELIEIREARMDDLDTIAKFNYNLAKETEGK
                     ELDMDVLTKGVKALLLDERKGKYHVYTVFDKVVAQIMYTYEWSDWRNGNFLWIQSVYV
                     DKEYRRKGIFNYLFNYIKNICDKDENIVGMRLYVEKENINAKATYESLNMYECDYNMY
                     EYEVVHS"
     gene            21575..21892
                     /locus_tag="KNP36_001909"
     CDS             21575..21892
                     /locus_tag="KNP36_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873783.1"
                     /translation="MGVLKGMFYVFLFLDLVSIFCFFFNKGKIASNKIVFNAIGVLTF
                     VLCFMLFSYYPNNNLIGKFIASLFFIFGVAGVMLKEKNFLYARLLLTVVIVFSTLRLF
                     VIQ"
     gene            22050..23009
                     /locus_tag="KNP36_001910"
     CDS             22050..23009
                     /locus_tag="KNP36_001910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBF0873784.1"
                     /translation="MIESKKSEKLLLSIIYIIFLVYILMIIRIILFRDVPIYAIFKGT
                     FRNVNLIPFYTIYQFIVDSNLDFMKATVNIIENIGIFIPMGIFLPIVCKNLNKKTIII
                     VIILVSLAFELTQYIFALGSSDIDDVILNSLGGIIGINIYINMNKLFPNDINRFKAII
                     GTSLVLGVIGLGVISKNYHNLLTFKFRPDRKISKILIEENREIIKDINKDTVDIVGTF
                     ESFKKGIITIKAGSNNKVKRPENLIDSDGNIRIYLNENTKLVSYIITKESKMDIVKYE
                     EFDVKNLDLLRRYDTINVWIDKENQPKDKHGIMASKLLIGLYE"
     gene            23124..23909
                     /locus_tag="KNP36_001911"
     CDS             23124..23909
                     /locus_tag="KNP36_001911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873785.1"
                     /translation="MEIIKYILYFFIYSFLGWTVESIGCSIASKRIINRGFLNGPICP
                     VYGFGAVIVISLLGRFNNVVIVFLLGMILTTILEYFTGFILETLFHAKWWDYSDRKFN
                     IKGRVCLKNAIYFGVMSVLIIRFIHPFIKYFVSIIPYRILISMAIITTLWTILDLIVT
                     IITLKKLDIKLNLLDDIITDLNDINVKLDKFDRGEIQALFKTINNDELEVREKINKIN
                     SKLDRIESNIILQKRVIKAFPHIKHKKQQEQLEHFKKIINEKR"
     gene            24201..25520
                     /locus_tag="KNP36_001912"
     CDS             24201..25520
                     /locus_tag="KNP36_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBF0873786.1"
                     /translation="MSEITSQMISTEEKKYVAKTQKIPYYPVAFKSGDGAMLYDYEGN
                     EYVDFLASAGSANVGHGNKEISQAVKEQMDDITQYTLAYFHSDPPVKLAEKLVEIAPG
                     DNDKKVLYSATGSACIDAAIKLARGYTGRTKIISMCESYHGSTYGAISISALSTNMRR
                     KMGPLLPEVYHFHYPDKNRTAKECLDEIEYAFAHYLPAEEVAAIFIEPIAGDAGIIVP
                     PVEWVQGLSKICKENGILLVSDEIQQGMGRTGKWFGIENFGVEADLIVLGKSVGGGLP
                     LGAVVGRTEIMQSLDAPAHLFTLAGNTTVCVAALKSIEIIEKENLLQKSIEMGDYIKA
                     GFEKLKEKYDIIGEIRGIGLSIGVDIVKGKGSNEKHPDATAKICYRCIQTGLIMIFLG
                     QSTLRVQPPLVITKEQVDKAMNIIDSAIDDYLNGRIGDEVYEVTQGW"
     gene            complement(25595..26023)
                     /locus_tag="KNP36_001913"
     CDS             complement(25595..26023)
                     /locus_tag="KNP36_001913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873787.1"
                     /translation="MKDNNNTNKTIQFGEKKASLENNIQKNKNIKLDNTHKVIPYPKN
                     RKKDDKKKGNKKKNTNTSKVNKNNYGHSFFNNKYKYKRKPYVIALYTVILILLAILII
                     TKLTDSTNKGNYSRNTVSDTHKNDIRNIVFNESNNFLICG"
     gene            complement(26114..27490)
                     /gene="hydG"
                     /locus_tag="KNP36_001914"
     CDS             complement(26114..27490)
                     /gene="hydG"
                     /locus_tag="KNP36_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster radical SAM
                     maturase HydG"
                     /protein_id="HBF0873788.1"
                     /translation="MFINHELINSLLEDAKNSTSDDIEKVLDKADRREKLSYKDIATL
                     LEVEDKKQLDRLFSIAGQIKNEIYGNRVVLFAPLYVSNYCVNECVYCGFSKCNKFKRK
                     KLTMEEIKEEVKILEKMGHKRLALEAGEDPKNCDINYILDCLDAIYSTYNENGNIRRV
                     NVNIAATSVDEYKLLKEKGIGTYILFQETYHKPTFIKMHGQSIKNDYYYHLTAFDRAM
                     EAGVDDVGAGVLFGLSDPKFEVLGLMMHNEHLEEKFGVGFHTISFPRLKKAEGMSLED
                     FPHLVSDDMFKKIVAITRLAVPFTGIIMSTRETAEMRNELLKYGVSQISAGSLTGVGG
                     YKAYEDGDNTEQFEVGDHRSPVEVLKELITDGYIPSYCTACYRKGRTGDRFMSLAKSR
                     QIHNVCTPNALTTLNEFLIDYGDEELKIMGKKLIAEEIGKIEREDIRNIVSNNMTALE
                     RGERDLYL"
     gene            complement(27491..28576)
                     /gene="hydE"
                     /locus_tag="KNP36_001915"
     CDS             complement(27491..28576)
                     /gene="hydE"
                     /locus_tag="KNP36_001915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster radical SAM
                     maturase HydE"
                     /protein_id="HBF0873789.1"
                     /translation="MTKNKIKYFIDKLYSINSLSFDELLYLIENIDNEEYNFEQNLRN
                     YLYKQASDMRNKHYGNRVYLRGLIELTNYCKNNCYYCGIQSSNKNIIRYRLSLDEILE
                     CCDIGYKIGYRTFVLQGGEDAYFTDDKICEIVSSIKNKYEDCAITLSLGEKSYDSYKK
                     YFLCGADRYLLRHETATDSHYKKLHPPNIELRTRKECLKNLKEIGYQVGAGFMVESPF
                     QNNEDLVRDLLYLKELNPHMVGIGPFIPHHDTIFKDYKHGDLEKTLLMLSITRLLLPK
                     VLLPATTALASINPSGRNAGLLAGCNVIMPNLSPQEFRKQYSLYDNKAFTGQEACEYH
                     QSLEENIKSLGLEVDYSRGDNIEWRRL"
     gene            complement(28612..29820)
                     /gene="hydF"
                     /locus_tag="KNP36_001916"
     CDS             complement(28612..29820)
                     /gene="hydF"
                     /locus_tag="KNP36_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="[FeFe] hydrogenase H-cluster maturation GTPase
                     HydF"
                     /protein_id="HBF0873790.1"
                     /translation="MSLNSTPQSVRVHIGLFGKRNAGKSSIINAITNQSAAIVSDIAG
                     TTTDPVFRPMEILPIGPCVLIDTAGLDDVGELGELRIGKSLDVLEKTDIALLVVDCQI
                     GISQEDLSLIEKFNDKNIPHILILNKIDTIKNQSEILNLTKNKVKCPVVSVSSTDKIG
                     IENLKNEIIKVLPKDSTEFKLVSDLIEPNDLVVLVVPIDKAAPKGRLILPQQQVIRDI
                     LDNGAISIVTKEDSLKETLSNLGKKPKLVITDSQVFPQVDKDTQKDIPLTSFSILFAR
                     QKGDLKELINGAYALENLKDGDKILMAEGCTHHRQTDDIGTVKIPNMIRKKTGKNITF
                     EFSSGVSFTEDINKYALVVHCGACMMNRAGMLSRIEKAKSFNVPIVNYGVLIAYVKGI
                     LERSLELFNY"
     gene            complement(29835..30086)
                     /locus_tag="KNP36_001917"
     CDS             complement(29835..30086)
                     /locus_tag="KNP36_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003361768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-only hydrogenase system regulator"
                     /protein_id="HBF0873791.1"
                     /translation="MKKVAVISAILEEPKECQFKFNEVVSGFKGIIKGRMGIPCEEEG
                     VSIVCIAVVGEMDTINSLTGKLGNIPHVSVKTSISKKEV"
     gene            complement(30467..31507)
                     /locus_tag="KNP36_001918"
     CDS             complement(30467..31507)
                     /locus_tag="KNP36_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HBF0873792.1"
                     /translation="MNLNLTNTINLMKKYLDIPSPAGYTENAVLEIKKDFENLSLDTI
                     LTKKGALIATLPGEDDSNQITISAHMDTLGAIVKEISSDGTLKYHKVGGGCWAAIEGE
                     NCTVITRKGKKIRGSVVFKYASTHIYGQTKAATERNEETMIIRLDEKVFTKQDVLDLG
                     ISVGDFVCLDHRFEATESGFIKSRYIDNKSAVAMVLEICRYFKENNLTPKHTTNFYIS
                     NYEEIGHGVSKCLPEKTKEFVAIDIAPTGPSQTSSEHGVTIVAKDNLSLYDFNLRNKL
                     VDVAEDNNLDYAVDVFTFYGSDASEAIRWGEDVQIACVGPGTNNSHHYERTHIEAIEN
                     TLKLLINYMLKE"
BASE COUNT        11957 a         3677 c         4968 g        10969 t
ORIGIN      
        1 atatgttaaa aaaatgataa tcacggagaa cttttacctt cttcaattaa tatattatta
       61 ttagtaataa ctttaaaatt atattactat tatataaaaa ttggcttaaa agaaggtgaa
      121 aaaagtaaat gaaaatatgc ataacagtag gtcatagtat actaaaaggt ggtaaaagta
      181 caggtgtaaa tggtatagtt gatgaataca attataataa aaaattagct cctatgttag
      241 ctgagatgct tataagtcaa ggtaatacag tagatgtaat aatttgtcca gaaaggcact
      301 ttatgtcaga aagagaagaa tttttctata gagttccaaa agtaaacagt ggtaaatacg
      361 atttattagt agagctacat ttaaataaag ctgatggaac acaatgtggt acagaagtgc
      421 tttactatgg cactgaagga ttagaatatg ctaaaagagt atctaataga cttggagaat
      481 tatttgaaaa tagaggagct aaaaaaagag aaaatttata tatattgaga aatacaaatc
      541 cagttgcaat acagattgaa agttttttct gtgataatgt gaatgattgt aacaaagcaa
      601 atgaatcagg ttatgattat atagcacgat tgattacaga aggtatattg aataaagata
      661 taaatatgtg agattatggt gatttaggta ttgattaata ccttttaata ttagatataa
      721 ataaaaatac aatgtattag tataatttaa actttcaaaa gatagattag tttgattatt
      781 gacaagagat acctccttga aaatattgat ttatcagtat atttaaggag gtatttaaat
      841 ataaaaattt aattaatttg ctactaaact ataggtttat agagtatata cttttatctt
      901 cagtctaata aataatataa aaatagtaga accttgtatt ataataatat aatgtagaaa
      961 aatatataga taagataaat ataataaggt ggtaatatat gaaatataca tttgaaaaat
     1021 ttaagttaaa tgaaaagata cttaagtcat tgaagagttt aggatataat ataccttcta
     1081 gagtacaaag agaagttatt ccaaaattat taaaaggtca aaacttagta gttaggtcaa
     1141 aaacaggaag tggaaagaca gcaagttttg caataccttt atgcgagaat ataaatgtag
     1201 attacaataa tattcaagct cttatagtgg ttccaacaag agaattagcc ttgcaagtaa
     1261 aagatgagat atcagatata gggagactaa agaaggtgag atgtagtgct atatttggca
     1321 aacaatctat aaaagaccaa atagctgaat tgaaacaaag ggttcatatt gttgtagcta
     1381 ctccaggcag aatacttgac catataaata gaggttctat taagttggaa aatgtaaagt
     1441 atttagtaat agatgaggca gataaaatgt ttaataaagg ttttgttgaa caaatggaaa
     1501 aaatattatt aaatttacct aaggagaaaa tagtaagtct tttttcagct acaatagatg
     1561 aagagataaa atatatatgt gaaaaatata tgctagatta cagtgttata aatatagaag
     1621 aaaatgagag cgatactaat caaaaaacaa gacaaataga tgacaaaata atcaaggcaa
     1681 atggaagaga gaagtacatc cttttaaaag aattaatata cagcgaaaat ccaaagagtg
     1741 tgataatatt ttgtaatacc aaagagaaag tatctaaatt atataacaag atgagtaaag
     1801 agggtttttt aataagagag ttacatgcag atttatcaca agaaagaaga atttttgtaa
     1861 ttaaggattt taaaaaccaa aaatttaata tattagttag tagtgatgta gcgtccagag
     1921 gaatacatat tgatgatatt tctttagtaa taaattatga tgtgccacaa gataaagaaa
     1981 actatataca tagaataggt agaactggga gaaaaggaaa tagtggaaag gcaattacta
     2041 tagtaactga aaaggatgaa aaatatatag agaatataga aacgtatata ggatataaaa
     2101 taaatgaatt aaaagatata gaaaaaagta gaattacaca tggcaaagtt ttgtttgaag
     2161 aatattcaaa aggaatccta aaaaaagtat caaagagaaa aaaagttgat aaaaattctt
     2221 acaaaagtaa agatataaaa ctaaatatag aaagtgaagt tgttaaatta tatttaaatg
     2281 ctggtaagaa gaagaaaata agagttttag atatagttgg tgcatttagt aatataaaag
     2341 gtataactaa tgatgatata ggtgtaattg aagttcaaga tttatgttca tatgtagata
     2401 tattaaatta taagggagat ttgatattaa aaaaatataa ggagatacct ataaagaaaa
     2461 aaatggttaa agtgaaaaga gatatacgat aatttagtca atattgatga attgctttgt
     2521 tatcgaaatg aagttgcaaa aaacacaata gaagttgtta aggatttgaa agctgaagat
     2581 atgaaacgaa aggtctctcc aattgactta gaaaggattt tggtgactgg aggagtaata
     2641 aagcatgaag attctatttg gttgttggac ttttggggga ataaagatat tgctggaatt
     2701 ttgcttatgc ctcctactcg tcatgttata cttcatttga atgattgttg taaatggaag
     2761 gaatattttc gtacaaaaaa gaaattttac agaagttaaa ttataataaa ttagacaaac
     2821 aatagataaa ttagcaagga atgttgattt tatctacatt ctaagttata ctatttttaa
     2881 gtggctaagg gaatagtcat tttaaatata agtaataaat atatacctat agggatatta
     2941 aaggggggaa atatatggca tattttaact ataacgacaa acagtgctac tataatgaaa
     3001 ttggggatgg tacaccatta ctttttttac atggaaatac agcctcttcc aagatgttta
     3061 atgatataat caatttttat aaagatgaat ataaagtaat attaattgat tttgtaggtc
     3121 atggaaaatc tcaaatggtc gataaatttt ctgctgactt atggtttgat gaggctatgc
     3181 aagtgatatg ttttttagaa gcaatgaact ataaaaaagt aaacataatt ggtagtagtg
     3241 gaggagctct tgttgcatta aatgttgcac ttgagagacc tgatttagtg aataaggtaa
     3301 ttgcagatag ttttgaagga gaagttcctc tagagtcatt tgtacaaaat gtgaaaatag
     3361 agcgtgaagc atctaagcaa gatgatggtg caaaagcttt ttatatttat aatcaaggag
     3421 aaaactggga aaaagttgta gataatgata cagaagctat ttttgaacat tataaaacta
     3481 taggaaagtt ttttcataag cctctagaaa ctatgcaacc agaggtgctt ttaacaggaa
     3541 gtagagaaga tgagtttgta tctctaatat ctagtgattt ttttgaaaat actttttcat
     3601 tacttcttga aaagattaaa aatggtaaaa tgtatttgtt tgataaaggt ggtcatcctg
     3661 caattttatc gaatggatta gatttttcaa atgtagcaaa gaaattttta gaggaataat
     3721 ttaaccaaaa tttacaataa tgaaaactgt aaaatggatt gcaaaactta caaaagtgag
     3781 tgtacatata cttcattatt atgatgaaat aggattgtta aaacaaaata ttctaatagt
     3841 caagttatta catttgtata tgcaatatgt atagaaagag atatcattag attgtaaagt
     3901 tgggattaaa taacaatatt aaattttatt tattcagata ttttagctta actatataaa
     3961 tgttagaaca aattcatata gttaagctgt aggattaaat aatttagtta aataagttta
     4021 ttatctcctc atcagataga ctttttaata caccttcatt agaaagttct ccatttataa
     4081 attgatttat aagctctttt ttactttctt gtaattttat tattttttct tctatagtcc
     4141 ctttagcaat caattttata acttgtactg aatttttttg accaaatcta tgagctctat
     4201 cactagcttg attttctact gatggattcc accatgggtc aaagtgaatt accatgtcag
     4261 cagatgtaag atttaaacca gttccgcctg cttttaaaga tattaaaaaa acttttttat
     4321 ccatactatt attgaactca tctacaagtt caagtctttc tttggcatta gttttaccat
     4381 ctatataatg gtatttaatt ttatacttat caagttcctt acttatgttc ttaagcacag
     4441 aagtaaattg tgaaaacaat aatattttgt ggttttcgtt tatactatcc ctaagtattt
     4501 ctaaacatgt ttcaattttt gaactttttt tattgtaatc ttttactact atacttgggt
     4561 ctaaacaaag ttgtcttagt ttagttaaat aagagaatat aactatttta tctttcttta
     4621 gatttttatc tttcatttta tcttgtatat cttttgaata tacactatat atctttttct
     4681 gctctttatt caattcaaca aaaaagtttt tttcaatctt atctggaagt tctttcataa
     4741 cttgtttttt acttcttcta agaataaaag gttttatcaa ttttttcagg tttttaacat
     4801 tatcttcttt atttataaac aattcctgaa actttgcttt actatataga tagccaggca
     4861 ttataaaatc aaatatagac cataattcta gtagattatt ttccataggt gtaccagtga
     4921 gtgcaaattt attttctgca tttatacttt ttacagactc agttactaaa gccactggat
     4981 tttttatatt ttgagcttcg tctaatatac aataatcaaa ctttatttca ctatatttgt
     5041 ctaaatcatt tctaagagta ccatatgttg taagtattac atcaaaattt tctaattcca
     5101 taaaacattt ttctctatct cttttatttc catgtatcaa taaaactttt atatctggag
     5161 caaacttttc aaattcattt ttccaattat aaatgagtga tgtcggtgta acaataagac
     5221 tttttttatt agataatgat aataaaaatg caatagtctg tattgtttta ccaagaccca
     5281 tttcatcagc taatatacca ccaaatttat aataatctaa aactttaaac caattgaggc
     5341 catttatttg atagtcacga aggtttgcat ttaaatttgc gggaatttct aaatttatgc
     5401 tatcaaaatt tctaaatttt tcacatatac tgtctagttc ttttttacca tctataaact
     5461 ttaaattttt actacgtatt acatcattta tatatagagc tttattttta tgaattttat
     5521 tattttttga tttatccatt atatctagat tttcaactaa ttcaaaaaaa tcttttgttt
     5581 ctctttctga taaatctata aagtttccat ctttaagttt ataaaaagta cgtttttctt
     5641 gaaaagcttt caaaatatcc ttgtactctt ttggatttat atcagatata ttaaaattaa
     5701 attctaggta attctggtta gtctgattga ttgaagcttg aattgatgaa gcgttatata
     5761 tttttttcaa tttaaacttc tcagaataat atatatctcc aaattccttt agagattcta
     5821 attgtaaatc taaaaatgta aataggtcat ggtcagttcc tttaaacaca taatgattat
     5881 tttcctttgt aaattgtgaa gaagtaagtt tattttcaat agtagcttcc ttttgtatgt
     5941 tggggagcac aaatttttta tcttcatcat catatatata ctttacatca caacatatgt
     6001 tgccatcaat catatcaaag tagaactcag atttaaaatc ttttgttata ttatttttta
     6061 tgttatcatc taaatgaact tcttgagata tagattttaa tctaggaact agcaatccta
     6121 aaacatcctt agaatcctct ttatcaaatt ttaactcttt agtctttgat aatatttgat
     6181 atatttttga ataatcatga gcttttttat gtgataataa atagatattg ccatcatata
     6241 aaagtacatc atttttttta gtaagtggaa caggtagtga atctttagaa tataagacta
     6301 ttttatcttc tatattttta aaatcaaacc ttacaggtag agtatcattt aatatctttg
     6361 gatgatattc ctctttagaa aaaataaggg taaaatcctt gtacttaata gcatttaaaa
     6421 attgttttaa agagcttgca tttatctcca taaatttttt tgaatgtgat gaagaaaagt
     6481 tgtatgaaag atttgtccca tattcttcta taatatctac taacttctca tcttcatcag
     6541 caaaataatg agtgttgggg ttgtaagtaa atttcttccc aaaatctaat tcatatccat
     6601 taagttttga atatgcaaat tcagtaatgt tttttaaaat gtacatttta ttaattccta
     6661 ttttaaattc agcaattgct ttatttgaat ccacatttat caatacatct aaattaaccc
     6721 tttctctttt agtattgtct aacaaagaaa gtaattgctt gcttaaatct aagctggttt
     6781 tagaatttgt attagaaagc ttatccttat ctgcacctaa tatatctatt agaataggag
     6841 gaacatcttt tttatttttt atttgtttta agctttttat cacaatagca actatatgct
     6901 tacatataaa aatacttttg ccctttgatt gacagtcagc gcaactacaa tcattttcaa
     6961 ttatcttaaa gtgctttata tctatagtta ttgaattaaa ataaaagcta taattatctt
     7021 cagaattgac tccaccacga aatgtcaaca gattattttg taggtcatca atatctatgt
     7081 ctatataatc aactaattga ttagtataat attttacacc tcttgaccat cttgatggtt
     7141 ctgtatttct tcttattagt ttatatatca tatctatttt catattattc accttacctc
     7201 actgtatata ttataatcta aatgcattca atttacactc taaatttaag actaaaatta
     7261 aggcagatat gaatagcttt tatctatcac gatatatgtg taaataacaa tttactatta
     7321 gatttttatt gaattatctt ataaactatg aatgaaaaat aattatataa atagattatt
     7381 aataaatata aaatcttatt attaaaaata ttcttagaaa ttacactgta taaaatataa
     7441 agtatgatat ttgaataaaa agaatgtata ataagtataa taatttgtat ttattattgg
     7501 gaaaggaaaa tgttaatatg gatagttata aacaacttaa agctaaaata ccctgtaagg
     7561 aaacaggtat agaaataaag aggactttat gtgatatttg ttcgccagga gtacattgtg
     7621 gaattgatgc atatgttaaa gatggtaaag taataaaaat agaaggtaca aaagaacatc
     7681 caatgaataa agggttgtta tgtaccaaag gtctttgcaa tagagaatat atctatagag
     7741 aagatagaat aaaaacacct ctaaaaagaa ttggaaaaag aggtgaagga aaatttaaac
     7801 caatatcatg ggatgaagct tatagagaaa tagcagaaaa attaaataga gtaaaatctg
     7861 agtatggagc aaagcatgta gcttttttta cgggttatgg aaagtggtat agaccttttt
     7921 tacaaaggtt tgcatcttca tttggttcac ctaattatgg tacagaatct agttcatgtt
     7981 caacatcagc acagatggct ggaaatgttg ctactggaag aaactttaca atgcaagata
     8041 tggagaatgc aaaaacttat ttagggtggg gatttaatcc atactactct aaatttttaa
     8101 atagtgtgaa tctaataaaa ttaaaagaaa aaggtctaaa atttataatt gtagacccta
     8161 gaataacacc gacaactcaa aaactagcag atttacattt aagaattaaa cctggaactg
     8221 atggagcttt agctcttgga atggcgaatc tatttataca aaaggattta atagatagag
     8281 aatacataga aaagcatgta catggattta atgaatataa agaatatgta aaattatttg
     8341 atttagatac tgtaagtaga attacaggag tttctaaaga taatatagta aaagctgttg
     8401 agatgttgtc acaaggtcca ttttgtataa atgaaagtgc agctccaata gttcatcatc
     8461 aaaatggatt tcaaaattat agagcaatga tgtctttatc cgctataaca ggtaattatg
     8521 atagaatagg tggaaacata ccaaaacaag attactttgc tggtaagata ggtggattcc
     8581 aaacactaga aaaagagttt gtaaaagaag ttctacctaa aaatataaat gaaagaattg
     8641 gtggagaaag atttcctcta tggaatgaaa tggtgactca atttcaagct atggatttac
     8701 ctaggcaaat agaagaaaag acaccatatg aaataagagc tttgttttgt catgggataa
     8761 atgctagaat gtttcctaat tcagggagac tttttaaagc gttgaatagt gtagattttt
     8821 ttgtgaatat agatttattt atgacagata catcaaaata tgcagatata cttttacctg
     8881 catgtacatc atttgagaga gaagaatgta agagttatcc aggagggtat attacatata
     8941 ccaaaaaagt tattgataaa ttatacgatt caaaatcaga tgtagaaata ctttcagatt
     9001 tagcaaatgc tatgaatata gatgatgatt tattaaaagc aggttatgaa gcaagtgtaa
     9061 gacatatgtt taaaaataca tgtgtagatg tagataaact taaagaaagt gatttaccat
     9121 taaaatgtaa agattttaag ccatatatag taggttcata tacaagagaa gggtatgata
     9181 ctagcacttc taggtttgaa ttaaaatcta caattattga aaaatataaa gattttgggc
     9241 tggatgcact accaacatat agaggattta atgataatat agatgatgaa tatactcatt
     9301 tattgacatc aggagcaaga atttcaaatg cactacattc aagacttcat gacatcaaac
     9361 tttcaagaat attaaaaaat gaagctaatt gtgatatttc tagcttagat gcaaaagaat
     9421 tgggtgttat cagtggagat tatataaaaa taactactaa gataggaagt ttggatgtaa
     9481 aagtcaatgt tactgataga gtcttatata agaatataca tatgtatcat ggatatagag
     9541 aagctgatat aaatagtatt atttgtgata attttgaccc ttatagtgga ttccctgcgt
     9601 atagaagttg taagtgtaag attgaaaaaa tgaatagata aatggagaga tataatgaaa
     9661 agtttattta aatttaataa agaattatgt acagcatgtg gagcatgttt gcttgcatgt
     9721 atagaccaaa atgataataa tatagacaat ggtgaacttt ttagacatgt atttacaata
     9781 gaggaaggtg aaaatataga atatttttca ttagcatgta tacattgtaa tgagccaaaa
     9841 tgtttaggtg tatgtcctaa aaattgtttt aaaaaagaag aaggattcat tgtattagac
     9901 aatcaaaact gtatagggtg taaactttgt gaaaaagctt gtgaatatgg agccttaatt
     9961 tatggaaatg atggtaaggc aaataagtgt aatggttgta ttgagagata taagtgtggt
    10021 atggattcac cttgtgtaat ggtatgccct acaggagcat taaaatttaa taaataattg
    10081 tattaaattg ctatactact tttaaataat tgtgttaaga attatttttt gatatacttt
    10141 tgtaatataa aatgtaaata aaacaaatac aaagtatata aaatatattt ttagaataaa
    10201 gtgtgcttta gattaaattt agaaaaataa attagacagg agaacttaat atggtaaaag
    10261 tattagcctt tatgggcagt ccaagaaaaa aagggaatgt agacacaata cttgatgaga
    10321 taataaaagg tgtaaatgat aataatgttg aagttaaaaa atattatcta aatgatatga
    10381 atattaaagg atgtcaaggc tgtctatact gtagaaaagt tcctacttgt gcatttaaag
    10441 acgatatgat tgacatatat gaagatataa aaagtgctga atatataata attggttcgc
    10501 cagtatatat atgtcaggta tcagctcaaa caaagctact tttagataga ttgtatcctt
    10561 taacagagat aaataagtct aaacatatac ctaggtttgg tcaaaaaaag ttaatcatgg
    10621 tctatactca agcagctcct atttcgtttt tatttaaaaa atattttaag tatactgcaa
    10681 aacatttaaa gggcatggga ttaaatcact acaaaactat agttgtaacc aaagcatttg
    10741 aaagaaattc cactaaaaaa aattttaagg tattgaaaaa agcctataaa cttggaatga
    10801 aaatagccat tgatatcaat ggatagataa aagtttaatt tatagtatag ctaaaggagc
    10861 attaattatt aatactcctt ttttgtataa aggtttctag aaaataacta ataaaaaaca
    10921 atattatttg aatacagata ttatacaagc ctagatatct aacttgtttt gaaaataaaa
    10981 gatttcaaat ttatttttgt taaaagataa caagccttca tctcgcatct tgccaagctc
    11041 tcttgacata gaacttctgt caacacataa aaaatcagcc atttcatttc ttgaaaaggg
    11101 aattgtaaac tggtggctac ctgtttgttc tatctgtttt gaaaaataca taagcaattt
    11161 ctcgcgagtt gttttacgag aaagtaattc tattttattg tgaagtaaaa tgtttttttc
    11221 agctattaat tgtagcatat tttcaacaag cctattatga aatacacatg cagatgaaca
    11281 aataccagtt acacttttaa actttataaa taaaacttcg caagaagatg ttgtggttac
    11341 tgtaacatta cttttatgta gtctagtaca tgcgaatacc tctccaaata aatctccagg
    11401 caagagttca gctacaatat tcctattccc ttcgatatct tcctttatta tatgagcact
    11461 tcctttaagc ataattccaa tagaagtaac ttcacttcca acagagaata ttatactatc
    11521 ttttgggtaa gtcttatcta caacacctaa acattccaac atttcttcaa gttcatcact
    11581 tttaattcct tcaaatagag gaattttttt aagtaagtct atatgctttt ctaaaaattt
    11641 tttcaaataa tcacttcctt gttgcatatg caaccgataa tttgttttca ttgtactata
    11701 ctaagtttat aaaagcaagg ggatataaaa atcctactac aagaaatttg aaataaagaa
    11761 atataggtat taaaaataaa tatataagaa atcaatactt taaattaaaa aaattttatg
    11821 aggtgatata aatgatgaga aaaataatta aaattgatga ggaaaagtgt aatggttgtg
    11881 gactatgtgt tgaagcttgt catgaagaag ctataggaat ggtaaatgga aaagcaaaac
    11941 ttttaagaga tgactattgt gatgggctgg gagattgtct gccaacttgt ccaacaaatg
    12001 cgatttcatt tgagtataga gaagcagcag aatatgatga agctgcagta aaagcaaata
    12061 tggaagcaaa gaaagcacaa aagaaaactt tagcatgtgg atgtccaggt tctcagtcta
    12121 agtcaataaa tagagaggtt tcaaatagta cgtctataag caatgatata gtagagataa
    12181 aaggttctca acttaatcaa tggccagtac aaataaaatt agtaccaact aatgcatcat
    12241 atttaaagaa tgcaagtttt ttaatagcag cagactgtac agcgtatgca tatggaaatt
    12301 ttcataataa atttatgaaa aataaggtta cattaatcgg atgccctaaa cttgatgaag
    12361 ttgactatgc tgaaaaactt acagagattt taaaagaaaa tgatattaaa aatatagtag
    12421 taacacgtat ggaagttcct tgctgtggtg gtatagtaaa tgctgttaag acagctctac
    12481 aaaatagtgg aaaaatgata ccatggcaaa tagttactat atctgtagat ggaaaaattg
    12541 tagatggaga aatttaatta agtgaattat agaaaaatat aataaatttt aataaataaa
    12601 aagggaggaa taaaaaatgg aaaaaatgtt ttgttttcaa tgtgaacaaa cagcaggagg
    12661 taaaggttgt actataaatg gtgtctgtgg taaaaagggg ggtacagcta acttacaaga
    12721 cgaacttaca ggagtgttga ttggtctttc aagagcaact attggaaata agaatagacc
    12781 aacaagtgaa acagataaaa ttatgataga ggggctattc actactataa cgaatgtaag
    12841 ttttgatgat gaagctataa aaagacaaat tgaaaaaact gaggtagaaa aaagtaaact
    12901 tgtacctaga tgttcagatt gttcaacaac ttgtaataga aatgataact atgatatgaa
    12961 ggatttatgg aatgataatg aggacatacg ttcattaaaa tcattaatct tatttggatt
    13021 aagaggtatg gctgcctatg catatcatgc aatggtactt ggttatacag acaaagacgt
    13081 aaatgaattt ttctatgaag gattaatagc agttggagga gacttgtcta ttgacgaact
    13141 tttaggtcta gttatgaaaa ctggagaaat aaacttaaaa tgtatggaat tgcttgatag
    13201 agcaaatact gaaacttatg gaacaccaga accgactcag gtatctatga aaatcgagaa
    13261 agggccattt attgtagtta caggacatga cctttatgat ttacacaaat tattagaaca
    13321 aacgaaagat aagggtataa atatatatac tcatggtgag ttattaccag cacatgcata
    13381 tccaaaacta aaagaatata aacatctaaa aggtaatttt ggtacagcat ggcaaaacca
    13441 gcaaaaagaa tttgataata ttcctgctcc aatattattt acaacaaact gtttaatgcc
    13501 tgttaaagat agttatagag atagagtatt tactacagaa gtagttgctt atccaggtat
    13561 ggttcatatt gatgaagata aagatttttc tagtgtaata gaaaaagctc ttgaacttgg
    13621 aggatataga gaagatgttc atatgactgg tattaatgga ggagatacat taactactgg
    13681 ttttgcaaga ggtacagttt catctgtaca agataaagta gtagatgctg taaagagtgg
    13741 agctataaga cactttttat tggttggagg ttgtgatggt gcaaaacctg gaagaaatta
    13801 ttacactgaa tttgtaaaac aagctcctaa agacactgtt atattgacac ttgcatgtgg
    13861 aaaatataga tttaatgatt tagaccttgg ggatataggt ggcttacctc gtttaatgga
    13921 tatgggacaa tgtaatgatg cttatagtgc aattaaagtg gcagtttcat tggcaaatgc
    13981 ttttgaatgt ggagtaaatg atttgcctct tagcatggta ctgtcatggt atgagcagaa
    14041 agctgtttgt atacttctta cactacttca tttaggtatc aaaaatatct atatagggcc
    14101 ttctttgcca gcattcttat ctaagaatgt attagatata ttggttgata aatttgcatt
    14161 gacacctata tctactcctg aagaagatat gaagaagatt ttaggataaa taaacatatc
    14221 tatacttaaa gatatttata gttaaaatat ttttaagtat gccacaatta agataagggg
    14281 ttaaacttaa aatttgatta aaaaatcaat tttgagatga ccctttattt attttttgta
    14341 ataattgaaa aataaacctg ctttcagtat attcttttta agaatctttg tattaaattt
    14401 ataatactta gatatataat atcttatata ttttatttta agtattaaag gtttgaatgt
    14461 aacttaaata ttaaaagagg aacattgtaa tatgtaactt gcataaaata tatatactat
    14521 agtgaaatta ttttgattaa aatttaaaat ataaggtgtt ttatgtgggg gtatatgtat
    14581 atgaaaaatt ctaattttaa tatattggca tttgatggtg gtggattaaa aggggcattg
    14641 agtatatcca tacttgagag gatagtaaaa gagtatccaa atctattaaa caatataaat
    14701 atgtttggag gtacatctac agggagtcta attgcactag ggcttgcgta tggtgtaagc
    14761 cctaaagaga taaaagaact ttactcaatt gaaaattcaa agtatatttt taataaaagt
    14821 tatgcagaaa tactcagacc aaagtatgaa aacaaaaact taaaagaagt tttattaagt
    14881 atatttccag aggaactaga attaaaagat ttaaataaat tagtaatgat accaagtttt
    14941 tatataggaa atgaggaaaa tgcatggaaa ccagtgtttt ataacaatat gccaaattct
    15001 tttacaaaga ctagcaaagt tgtagatgta gcaatggcaa gtagtgctgc tccggtattt
    15061 tttccaacat ataatcgtca tgttgatgga ggaataatag caactgaccc gagtttagcg
    15121 tgtataattc atgccattga cagtggattt aaacttaaga atacaagact tttttcaata
    15181 gggactggat atgtatataa cagtataaag gcagatacta ccgaatgggg agctattgac
    15241 tggataatta ataaagaacc cgatttacca attatatcta ttaccttaga aggaaattct
    15301 caaatgagtc agttattttc tcaaaaactt cttggagata attactatag attaaatcct
    15361 aagatggaaa aagatgtagc tatggatgat tgtgatgcat tagaatatct aatgtcttta
    15421 ggagaaaatt gtgatataaa agatgctttt ggatggataa agaaaaagag cttttataga
    15481 aattagattc aatttgcaat tgtattttta cacatgattt cattgagtag gtaaaaataa
    15541 taaaatgcag attattaagt tacttcttag ggaataaata aagtataatt tatttaagga
    15601 gtgatgaaaa tgataaaact tgctactttt tcaggtggat gtttttggtg tatggtaaaa
    15661 ccttttgata agtatgatgg agttattaaa gtagtttctg gatatacagg tggtcatgtt
    15721 gaaaacccta catatcaaga ggtatgctca ggaactactg gtcatttaga agcaattcaa
    15781 ataacatatg atgatgatat aataagttat gatgaacttc taaatatctt ctggaaacag
    15841 attaatccta cagatgatgg tggacaattt ggtgataggg gaactcaata taagactgct
    15901 atattttatc atgatgaaga acaaaaaaat atagctttag agtcaagaga acatctggaa
    15961 aatagtaaaa tatttgatag taaaatagtg actgatataa ttccagcaac taaattctac
    16021 gaagcagaag aaaatcatca ggattattat aagaaaagac cattaaacta caatatgtat
    16081 tataaagggt ctggaagata taattttgta aaaagccatt gggatggaaa caatataaat
    16141 agggaagagt taaaaaagac tctaactcct atacaatttg aagtcactca aaatgatatg
    16201 acagaagtac cttttgaaaa tgaatattat gacaataaca aagagggaat ttatgttgat
    16261 attgtaagtg gagaagtgtt attttcttca aaagataaat ttgattctgg atgtgggtgg
    16321 ccaagttttt caaagccagt tatagataaa tctatcattg agagaagtga tttctcacaa
    16381 ggtatgtaca gagttgaagt aagaagtgct aaaggaaatt ctcatttagg tcatgtattt
    16441 gatgatggtc caaaagaact tggaggttta agatattgta taaattctgc ttctcttaaa
    16501 tttataccaa gagaaaatat ggaagcttta ggatatggag aatatttaaa actttttgag
    16561 taattaggaa tatttattat aaacttatct aaaaggtgaa aatataaaaa aatattttca
    16621 ccttttgttt ttttgtcaat aatatgataa attattaatt gtaatcttat ttataccaat
    16681 agattaagaa tttaattttg aaagagagaa aacaaatgaa tttaaaagac tttaatggaa
    16741 agagattaaa atcagctaga atttttagag caaagacgat agaacagttg tctaaagaaa
    16801 ctaaaataaa taaaaaagat ttaaaagctt ttgaggaaaa taagtatgta ccaaatatag
    16861 aaaatacatt aaaattatct aatatattaa attttccaaa agagtatttt tataaaaatg
    16921 aaaatataaa tatcgttgta gaggatagcc actttaaccc tcaatctaaa ctacctagag
    16981 tagaagagat ttcttataga gaaaaaataa ttataataca taaaatatat tcatttatgg
    17041 agaattatat taagtttcca aaagaaaact tgccaaatag aaaagtaatg tcagatatta
    17101 atataaatga tatagaatct cttgcatata agactagaga gttttgggat ttaaatagta
    17161 ctccaatagt aaatatggta agtttgttag agtctaaagg gattataata tcaggtatga
    17221 atgtagatag aaaaggggca actatcttta ctcaaaaaca gagaattagt aaagaatcta
    17281 aatatctaat atctctgggt aatgacaaaa agtcagcatc aattagaaat tatactttgg
    17341 catgtgagct tggatatata atatcaagtg aattaagaat accaagtaag caattttcag
    17401 aagatgagta tgcctgtgca tttttattgc caaaagagag ttttttaaaa gatttgactc
    17461 atccagaaga tttagattat tatgtagaac taaagaaaaa atggattgta cctatatctg
    17521 ctatgatttt tagagcatat aatctagaaa agataaatta caaaaaatac aattatctta
    17581 tgaatgaaat ggataaaaaa ggctggttga tagaagaacc actagacaaa atgaaaggtt
    17641 caagcccaac gtatttaaaa agagcagttg aattattgat agaaaataaa ataatgagtg
    17701 taaatagtat agtatcaagt ttagaggaat ttggaataaa tctttatcca gaagacttag
    17761 aattattgat gggattgaaa aaaggattgt tatctcaaga ggtaaataaa aaaagtaaag
    17821 ttataaaatt tgatggtaaa aaataggttt atattttagt attaaaatta aaagcaggta
    17881 caaatgattt aaacattaac ttagttaaag gtcttttcaa taagtcattt acctgctttt
    17941 agtgtaagaa agaatattga atctaaagtg tttttgaaag tgcaatatat tcccttaaaa
    18001 cagaacaaga tttattaaat tcattttgct catattcagt catattgatt tcaataattt
    18061 cttcaatacc atcttttcct ataacacatg gaacacctgc aaatacattt ctttcgttat
    18121 attgaccttc tagtaatgta gaaactggaa gaactttttt ctcattgtgt agtatagctt
    18181 ttacaatttc tactaaagca gtacctatac caaattctgt acaatcttta ccatttatta
    18241 tacttatccc tgttttttta tttttttcaa ctattgatgg taagtctaaa ttgctataag
    18301 tacttgggtt gtcttttatc atgtctaaga ttggtttacc accaattgaa acatgagacc
    18361 aaggaaccat ttgagaatct ccatgttcac ccatagaata agcttgaatt gattgttgag
    18421 cgattccagt ttcttcagat aaaatccttc taagtcttgt tgaatctaaa gctgttccag
    18481 ttccaatgac tttgttttta ggaaagccag atttttccca aatataattt gtaactacat
    18541 caacaggatt agatatgact acaaatatac catcaaagcc agaatcaact atgggtttta
    18601 ctatagattt tatcattcca atagttggtc ttagtaaatc taatctagtt gtgttttgtc
    18661 tacgtaaagg cccttctgaa gagtctgcaa cacttatcac tactatgtca gaatctttac
    18721 agtcagaaaa agttcctttt tctatatgta ctttatgtgg cagatatgaa actgcatcag
    18781 ctaaatctaa agcttgagct tttgatttag attcatctat atcaatcata aagagttcat
    18841 cacaaactcc ttgagttatt aaactaaatc cacaatgaga accaacatgc cctgaaccta
    18901 caatagatat ttttcttggc tttattgcca ttttaaatca ctccccctaa aataacgata
    18961 cattgaaaat tatagatgtt attaaaagct gtttttggat attttaatat tctattattt
    19021 cagaaaattt atttaatatg attttatact aaaattttta aaaaagcaat gttaatatac
    19081 tctctattag tgaatattaa agtattatat gtatattaat aattattaaa atatgtaatg
    19141 tcactgatag ttagaatatt taagtgctaa aagatgtgta taaataataa tgatgtcagt
    19201 ttataatgat attaaattga gatatactgt ttctctaaat taaaaaataa aggagtaaat
    19261 gtgttatgaa ttatcataca aaagaagaat tggtggaagc actgagagta gtatcttcaa
    19321 gtattattaa ttgtggaaaa ggacagaaga aattttctga ggagacatct catcatacac
    19381 gttttaagaa tattatagaa gtaatgtata tttcaaaatc attaataatg gatgaaatta
    19441 gtaaaagaga ttgaagctta ttttgcaatt taacatgttt taatatacat tttattatat
    19501 aagaaaataa gtaaacatac atgttataaa atattgaaat aatatacaat tataaatttg
    19561 ttaacattaa tatctatatg ttaaaatata gtagaagatg ttagtaaata ataggatgag
    19621 ttctatttta atacaattaa attaagctta gtttgaaatt tgtatctaaa aagtaaagta
    19681 atctagaatt aagaaaatgg agatagaatt ataatggaaa aattatatta tacaaatcag
    19741 tatataagag attttacagc agaaataatt gaaataaaag aagtagaaaa taagtatcat
    19801 gttttattag ataagacagc tttttttcct ggtggaggag gtcagtttgg agacctggga
    19861 aaaatagaga atgatgatgt aataaatgtg tatgaagatg gaaaaaaaat ataccatgta
    19921 ttagataaaa aacctataaa gatacataag gtaaagtgta gtattgattg ggatagaaga
    19981 gaagatggaa tgcatcaaca ttttggacaa catgtattgt ctggatgttt ttttaaaact
    20041 tttaatgcaa atacgacagg ttttcatttg ggaaatgagt atagtacagt agatatagaa
    20101 ggtaatttag aagaggataa aattagagag atagagttgt ttgccaatga aattattcgt
    20161 caaaatatac aagtagagac attacttcca acgaaaaaag aactaaaaaa gatttggtta
    20221 agacgtgatt tgccaaatac tgatgaagag ataagagtaa taaaaatagg tgatttagat
    20281 acgaatgcat gttgtggagt gcatccaaaa tcaactggtg aattgagaat gataaaaata
    20341 aagaaatggg aaaaacataa gtcaagtaca agaatagagt ttctagcagg taaaagggca
    20401 gtggatgaag tattgaagag ggatatatat ttgactaaaa tatgtagata tttaagctgt
    20461 agtgaggaag atgctataaa tggtattgta aatctaaata gtaaagtgga agaggcttta
    20521 attaaaaaaa gaaggcttga agaagtagta tctacatatc aggtcaaaga aatgattgaa
    20581 aaagcaaata aggttggcaa tatttcggtc attaaaaaaa tttatgatga tgaagatttg
    20641 aaatatgtaa ataagatagc aaataaaatt gcagaatatg aaaatagtat tgcattatta
    20701 gctgttaaat ttaatgataa aataaattta gtttttgcat gttctaaaaa tttaaaagat
    20761 attaatatgg gagttttatt aaaggatgca ataaatctta tagatggcaa gggtggtgga
    20821 agtaaagtat tagctcaagg aggaggtaag aataatggaa atttagaggc tacacttgat
    20881 tatgcattta tgaagataga aaaaactcta taaatatatt atataaaaaa ccttagtaga
    20941 taaaatagat atggaggaat aagtatggag caacaaaagg actacataga gttatatgaa
    21001 aatgaagaac taatagagat aagagaagca cgtatggatg atttggatac aatagcaaaa
    21061 tttaattata atttggctaa agaaactgaa ggaaaagaac ttgatatgga tgttttaact
    21121 aaaggtgtaa aagcattgtt attagatgag agaaaaggaa aatatcatgt atatacagta
    21181 tttgataaag ttgttgcaca gattatgtat acatatgagt ggagtgattg gagaaatgga
    21241 aatttccttt ggattcagag tgtatatgta gataaggaat atagaagaaa aggtatcttt
    21301 aattatttat ttaattatat aaaaaatata tgtgataaag atgaaaatat agttggaatg
    21361 agattatatg tagaaaaaga aaacataaat gcaaaagcaa catatgagtc tttaaatatg
    21421 tatgagtgtg attataatat gtatgaatac gaagtagtac attcgtaata taaatttgta
    21481 atactgttat actgatgtta taaagtattg attatattga cgattatatg aaataaactg
    21541 gatattataa ttagaatttt tagggggtat aaaaatgggc gttttaaaag gaatgtttta
    21601 tgtattttta tttttagatt tagtgtcaat attctgtttc tttttcaata aaggaaaaat
    21661 agcatctaat aaaattgtgt ttaatgcaat aggagtactt acatttgtac tttgttttat
    21721 gctttttagt tattatccta ataataatct tattggaaaa tttattgctt ctctattttt
    21781 tatatttgga gttgcaggag ttatgttgaa agaaaaaaat tttttatatg ctagacttct
    21841 tttaactgta gttatagttt tttctacatt aagattgttc gttattcaat aaaatgtatt
    21901 tgtataaaaa tttattaaag tctacacatt taagtgtagg cttttttgat tttttgtttg
    21961 aaaattaagg aaattttaag gaaattttaa aatcgtctta aatatttatt gatatactta
    22021 aaatattaat agcgaaagga gacttatcag tgatagaaag taaaaagtca gaaaaattgt
    22081 tactgtcaat tatatacata atatttttgg tatatatttt aatgattata agaataattt
    22141 tatttagaga tgtaccaatt tacgctattt tcaagggaac gtttaggaat gtaaatttaa
    22201 ttccatttta tacaatatat caatttatag tagatagtaa tcttgacttt atgaaagcta
    22261 ctgtaaatat tatagaaaat ataggtatat ttattcctat gggaattttt ttacctatag
    22321 tatgtaaaaa tctaaataaa aaaactataa ttatagtaat tatacttgtt agcctagcat
    22381 ttgaattaac acaatatatt tttgctcttg gaagtagtga tatagatgat gttattttaa
    22441 attcattagg tggcataatt ggaattaata tttacataaa catgaataaa ttatttccca
    22501 atgatattaa cagatttaag gctataatag gtactagttt agttttagga gttataggat
    22561 taggagttat ttctaaaaat tatcataact tactaacttt taaatttaga cctgatagaa
    22621 aaatatcaaa aatattaatt gaagaaaata gggaaataat taaagatata aataaagata
    22681 cagtagatat agttgggaca tttgagagct ttaaaaaagg aataataact attaaagcag
    22741 gttctaataa caaagtaaag agaccagaga atttaattga ttctgatgga aatataagaa
    22801 tttatttaaa tgaaaataca aaattagtat cttatataat taccaaagaa tcaaaaatgg
    22861 atatagttaa atatgaggaa tttgatgtga agaatttaga tttattaagg agatatgata
    22921 ctattaatgt ttggattgat aaagaaaatc agccaaagga taaacatggt attatggcta
    22981 gtaaattatt aattggattg tatgaataaa atattaaaca agaataaaag aataacaaat
    23041 ataaaaaacg aaaaaactat ttctataatt atttttacgt tgtgcataaa ataagaacat
    23101 tagtgaagga gtagagataa attatggaga taataaaata tatcttgtac ttttttatat
    23161 attcattttt aggatggaca gtagaaagta taggatgttc tatagcaagc aaaagaataa
    23221 tcaacagagg ttttttaaat ggtccaatat gtcctgttta tggttttgga gcggtaattg
    23281 tgatatcact attgggaaga tttaataatg tagtaatagt atttctatta ggaatgattt
    23341 taactacgat actagaatat tttacaggat ttattttaga aaccttattt catgctaaat
    23401 ggtgggatta ttctgacaga aaattcaata taaagggtag agtatgttta aaaaatgcaa
    23461 tatactttgg tgtaatgtct gttttaataa taagatttat acatccattt ataaaatatt
    23521 ttgtaagtat aattccatat agaatattaa tttcaatggc tataattaca acactttgga
    23581 ctatacttga tttgattgtt actattataa cacttaaaaa attagatata aagttaaact
    23641 tactagacga tataattaca gaccttaatg atataaatgt gaaattggat aaatttgata
    23701 gaggagaaat acaagcttta tttaaaacaa taaataacga cgaattagaa gttagagaaa
    23761 aaataaacaa aataaatagt aagttggacc gtatagagtc taatattatt ttacaaaaaa
    23821 gagttataaa agcttttcca catataaaac ataaaaaaca acaagagcaa ctagaacatt
    23881 ttaaaaaaat tattaatgag aaaaggtaat tatacaattt aatgaagacg aatagaataa
    23941 tggtatttat aagatgattt tcagaggact ctataaaaat agaatagagt cctttatttt
    24001 ttgaaaaata atgtttattt gataaaaata aaatatattg tttctgaata acaaatattt
    24061 tgaaaattat aaaaacatat attgacaatt tgtgtcaaaa atactaacat taagtatata
    24121 aagaatttta tatgagaata tctttataaa tcgcaataat tttaaaacat aaatttattt
    24181 aaagagggga tgatttgcca atgagcgaga taactagtca aatgataagt acagaagaaa
    24241 aaaaatatgt tgctaaaact caaaagatac cttattatcc agtagcattt aaatcaggtg
    24301 atggtgcaat gctatatgat tatgaaggta atgaatatgt agatttttta gcaagtgcag
    24361 gctctgcaaa tgtaggtcat ggtaataagg aaatctcaca agcagttaaa gaacaaatgg
    24421 atgatataac acaatataca cttgcatatt tccatagtga tcctcctgta aaattagctg
    24481 agaagcttgt ggaaatagcc cctggagata atgataaaaa agtactatac agtgcaactg
    24541 gttctgcttg tatagatgct gctataaaat tagcaagagg atatactgga agaacaaaga
    24601 taatatctat gtgtgaatct tatcatggaa gtacttatgg agctatatct atatctgctt
    24661 taagtacaaa tatgagaaga aaaatgggtc cattgttacc agaagtttat cacttccatt
    24721 atcctgataa aaatagaaca gctaaagaat gtttagatga gatagaatat gcttttgcac
    24781 actatctacc agcagaagag gtagctgcaa tatttataga gccaattgca ggagatgcag
    24841 gaataatagt gcctccagta gagtgggtac aaggtttaag taaaatatgt aaagaaaatg
    24901 gaatattact tgtaagtgat gaaatacaac aaggtatggg aagaacaggt aagtggtttg
    24961 gtatagaaaa ttttggtgtt gaagcagacc ttatagttct tggaaaatct gttggaggtg
    25021 gattacctct aggagcagtt gttggaagaa cagaaataat gcaaagtctt gatgcaccag
    25081 cacatttatt tactttagct ggaaacacaa cagtatgtgt ggctgcttta aaatctatag
    25141 agataattga aaaagaaaac ttacttcaaa agagtataga aatgggagat tatattaaag
    25201 caggatttga aaaactaaaa gaaaaatacg atataattgg agaaataaga ggcataggat
    25261 tatctatagg agttgatata gttaaaggaa aaggttctaa tgaaaaacat ccagatgcta
    25321 cagctaagat atgttataga tgtatacaaa ctggattaat aatgatattc ttaggacaat
    25381 ctactttaag agtgcaacca cctctagtaa taactaagga gcaagtagat aaagcaatga
    25441 acatcataga ttctgcaata gatgattatt taaatggtag aattggtgat gaagtatatg
    25501 aagtaactca aggttggtaa aataaatatt aaatgaaaat aggagttatc tcaattttag
    25561 aaaattattt ctgaaatgag ataactcttt taagttaccc acaaataaga aaattgtttg
    25621 attcattaaa gactatattt cggatgtcgt ttttgtgagt atcagagaca gtattacgag
    25681 aataattacc tttattcgta ctatctgtta atttagttat aattaagata gctaaaagaa
    25741 taagaattac tgtgtataaa gcaataacat atggttttct tttatatttg tatttgttat
    25801 tgaaaaaaga atggccataa ttatttttat ttactttaga tgtatttgta ttctttttct
    25861 tgttaccttt ctttttatca tccttttttc tatttttagg gtaaggaatg actttgtgtg
    25921 tattatcaag tttgatattt ttattttttt gaatattgtt ttccaggcta gccttttttt
    25981 ctccaaattg aatagtttta ttggtattgt tgttatcttt caatgttaat ctccctccct
    26041 taaactttcc ctttagataa tattactact aacctatgga atatacaata aataatatat
    26101 aagtaataaa attttatagg tataaatctc tttctccacg ctctaaggca gtcatattgt
    26161 tagatactat gtttcttata tcttctcttt ctatcttacc tatttcttct gcgataagtt
    26221 ttttacccat aattttaagt tcttcatctc cataatcgat taaaaattca tttaatgtag
    26281 taagagcatt tggtgtacat acattatgga tttgtcgact tttagctaag ctcatgaatc
    26341 tatcgccagt tctaccttta cgataacaag ctgtacaata actaggtata tatccatcag
    26401 taatcagttc tttaagcacc tcaacagggc ttctatggtc tccaacttca aattgttctg
    26461 tattgtcacc atcttcatat gctttatatc ctccaacacc tgttagagaa cctgcactaa
    26521 tttgtgatac accatatttt agtaactcat ttctcatttc agcagtttct ctagtggaca
    26581 ttatgattcc agtaaaagga acagccaatc tagttatagc tactattttt ttgaacatat
    26641 cgtcagaaac taagtgagga aaatcttcta agctcatacc ttcagctttt ttcaatctag
    26701 ggaaagatat agtatggaaa cctacaccaa atttttcctc taagtgttcg ttgtgcatca
    26761 taagtcctag aacttcaaat ttagggtcag ataaaccaaa taaaactcct gcaccaacat
    26821 catcaacacc agcttccata gctctatcaa aagctgttaa atggtaataa tagtcatttt
    26881 ttatagattg accatgcatt tttataaatg ttggtttgtg ataagtttct tggaataata
    26941 tataagttcc tattcctttt tcttttagta atttatactc atctacactt gtagctgcta
    27001 tgttaacgtt tacccttctt atatttccgt tttcattata tgttgaataa attgcatcta
    27061 agcaatctaa gatgtaattt atatcacaat ttttagggtc ttcaccagct tctagagcaa
    27121 gtcttttatg acccattttt tctaatattt taacctcttc ctttatctct tccatggtaa
    27181 gtttttttct tttaaatttg ttgcatttac taaaaccgca ataaacacat tcatttacac
    27241 agtagtttga tacataaaga ggggcaaata aaaccactct attaccatat atttcatttt
    27301 ttatttgccc agctatacta aataatctat ctagttgttt tttatcttct acttcaagaa
    27361 gtgtagctat atctttataa ctaagttttt cccttctatc agccttatca agtacctttt
    27421 caatatcatc agaagttgaa ttttttgcat cttctaataa agaattaata agttcatggt
    27481 ttatgaacat ttacaaacgc ctccattcaa tattatcacc gcgagaatag tcaacttcaa
    27541 gtcctaatga cttgatgttt tcttctaaac tttggtgata ttcacaagct tcttgaccag
    27601 taaaggcttt gttatcgtaa agagaatatt gttttctaaa ttcttgagga gaaaggtttg
    27661 gcataattac attgcaacca gctaaaagac ctgcatttct accactaggg tttatagatg
    27721 ccaaggctgt tgtagcgggt aataaaactt ttggaagtag aagtcttgta attgaaagca
    27781 taagtaatgt cttctctaaa tctccatgtt tataatcctt aaaaattgta tcatggtgtg
    27841 gaataaaagg tcctattcca accatatgag gatttaactc ttttaggtat aataaatcac
    27901 gaacaaggtc ttcgttgttc tgaaatggtg attcaaccat aaatccagca cctacctgat
    27961 aaccaatttc tttaaggttt tttaggcatt cttttctagt tctaagctca atgtttggcg
    28021 gatgtaattt tttataatga ctgtctgtag cagtttcatg tcttaaaaga tatctatctg
    28081 caccacataa aaagtatttt ttatacgaat cataactctt ttctcctagt gatagagtta
    28141 tggcacaatc ctcatattta ttttttatac ttgaaacaat ttcacatatt ttatcatcag
    28201 taaaatatgc atcttcacca ccttgcaaaa cgaatgttct gtatcctatt ttataaccta
    28261 tatcacaaca ttcaagtatt tcatcaagtg aaagcctgta tcttatgata tttttattag
    28321 aagattgtat tccacaatag tagcaattat ttttacaata gtttgtaagc tctataagtc
    28381 ctctcaagta gactctattt ccataatgtt tatttctcat gtcgctagct tgtttataaa
    28441 gatagtttct taaattttgt tcgaagttat attcctcatt gtcgatattt tctattaaat
    28501 atagtagttc atcaaaactt aatgaattaa tgctgtaaag tttatctata aagtatttaa
    28561 tcttattttt agtcatattc aaatatgtaa ttattaagta tagttaaatt tttaataatt
    28621 gaaaagttca agtgatcttt ccaaaatacc ttttacatat gctattaaga caccatagtt
    28681 tacaataggt acattgaaag attttgcctt ttctattcta gataacattc cagctctatt
    28741 catcatacaa gctccacagt gaactacaag ggcatattta tttatatctt cagtgaagga
    28801 tactccagaa ctaaattcaa aagtaatgtt tttgccagtt ttctttctaa tcatattagg
    28861 aatttttact gttccaatat catcagtttg tctatgatgg gtacatcctt cggccatcaa
    28921 gattttatca ccatctttta aattttctaa agcataagct ccattaatca attctttaag
    28981 gtctcccttt tgtctagcaa acaatataga aaaagatgta agaggaatat ctttttgtgt
    29041 atctttatct acttgtggaa atacttgaga gtcagtaata acaagttttg gttttttgcc
    29101 taaattagat agagtttctt ttaaactatc ttcttttgta actatagaaa ttgcaccatt
    29161 atccaaaata tctcttataa cttgctgttg aggaagtata agtctacctt ttggagctgc
    29221 tttatctatt ggaacaacta aaacaactaa atcatttggt tcaattaaat ctgataccaa
    29281 tttgaactca gtgctatcct taggcaaaac ttttattatt tcatttttta aattttcaat
    29341 tccaatttta tctgttgatg agacagaaac aactggacat ttaactttat ttttagttaa
    29401 gtttaaaatt tctgattgat tcttaatagt atcaattttg ttaagaatta gaatatgagg
    29461 gatattctta tcattaaatt tttcaattag tgacaaatct tcttgtgata taccaatttg
    29521 gcaatccact actagtaaag ctatatctgt cttttctaaa acatctagtg atttacctat
    29581 tctaagttca ccaagttcac caacatcatc aagaccagca gtatctataa gaacacaagg
    29641 tcctatagga aggatttcca ttggtctaaa tactgggtct gtagtagttc cagcaatatc
    29701 tgagactatt gcagcacttt gatttgttat agcatttatt atgctagatt tacctgcatt
    29761 tcttttacca aagagaccta tatgtactct taccgattgt ggagtagaat ttagactcat
    29821 ttgtactcac caccttaaac ttcttttttt gatatactag tttttacaga tacatgaggt
    29881 atgttgccca atttaccagt caaactatta atagtgtcca tttcgccaac aactgctata
    29941 catacgattg agacaccttc ttcttcgcaa ggaatgccca ttcttccttt aataatacct
    30001 ttaaaacctg atacaacctc attgaattta aattgacatt cttttggttc ttccaaaata
    30061 gcacttataa ctgcaacctt tttcataaat atcctcctaa ctcagaaaat atgtcttaaa
    30121 caaatccaaa atcaaaaaac ttttctttgt aaagaaaagt ttctacaaaa gaaaagttat
    30181 taattacaca agtataatgt gctatattaa actatttcct tacagattag ataactcttt
    30241 tctggtaggg ttagcttgta aaaatttaat ttaacaacaa gtaactgaag aaaattttta
    30301 tacaatttat ataaattata ataaaaatta actaaagaaa attgaagtta cttatataat
    30361 agtagtaaat tgaaattaag tctatagaaa aaccaatttt tgtataaaaa taaaaattaa
    30421 agttaattat ttgttaagaa ttgactttgg taaaatatat aattaattat tctttaagca
    30481 tataatttat aagtaatttt agtgtatttt caatagcttc tatatgtgtt ctttcataat
    30541 ggtgactatt gtttgttcca ggaccaacac atgctatttg aacatcttct ccccaacgaa
    30601 tagcttctga agcatctgaa ccatagaaag taaatacatc gacagcgtag tctaaattat
    30661 tgtcttctgc aacatcgaca agcttgtttc ttaaattaaa atcatataat gataaattat
    30721 cttttgcaac tatagttaca ccatgttcac tagatgtttg acttggtcca gtaggtgcta
    30781 tatctattgc tacaaattct tttgtttttt caggtaaaca tttagaaaca ccatgtccaa
    30841 tttcttcata attacttata taaaagttag tagtatgctt aggtgttaaa ttgttttctt
    30901 taaaatatct acatatttca agaaccattg ctacagctga tttattatct atatatctag
    30961 attttataaa accagattct gtagcctcaa atctatggtc taggcataca aaatccccaa
    31021 cacttattcc taaatctaat acatcttgct ttgtaaatac tttttcatca agtctaataa
    31081 tcattgtttc ttcatttctt tcagtggcag cttttgtttg accatatata tgagtagaag
    31141 catacttaaa tacaacactt cctctgattt ttttaccttt tctagttata acagtacagt
    31201 tttctccctc tatagccgcc caacatccac caccaacttt atggtattta agagtaccat
    31261 cagatgatat ttcttttact atagctccaa gtgtatccat atgtgcagat attgttattt
    31321 gatttgaatc atcttcacca ggaagagtag ctataagtgc accttttttt gtaagaatag
    31381 tgtcaagact taaattttca aaatcttttt tgatttctaa aactgcattt tcagtatatc
    31441 cagctgggct tggaatgtcc aaatattttt tcattaaatt tatagtatta gttaaattta
    31501 aattcatatt gtttcctcct aaataaatat atttatacaa attataacat aaatacaaat
    31561 gttctgaaaa c
//
LOCUS       DAEHWM010000040        31113 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.041, whole genome shotgun sequence.
ACCESSION   DAEHWM010000040 DAEHWM010000000
VERSION     DAEHWM010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 31113)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31113)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31113
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.041"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            142..1068
                     /locus_tag="KNP36_001919"
     CDS             142..1068
                     /locus_tag="KNP36_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conserved phage C-terminal domain-containing
                     protein"
                     /protein_id="HBF0873793.1"
                     /translation="MSNSFYQLNSAVLYFNEKRDVNRIRFNHYVMRKENIQRLKGTLP
                     RGQFMMTVRKAASDLDVSISTISRLVNEFIDLGILRLISRGVKGNCCSVYSYVCSESS
                     NAEIVTKNGDIFKNIEKYIDATINNNQKTMKYKHRNELFKNSNTNIYSRINQESIDKD
                     YDLIIHTGYETENETKKKELLKNNLNKKNLNKNTFENSDEDLTEDSTYKNPESIHEII
                     IRKLNSESGKNFKADLSITKALIDKRLKEGYSLEDFYKVIEAKVRRWRYTDMEIYIEP
                     TILFGYEFESYLNEESSLSACNYGDMCYEDMY"
     gene            complement(1257..1877)
                     /locus_tag="KNP36_001920"
     CDS             complement(1257..1877)
                     /locus_tag="KNP36_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873794.1"
                     /translation="MVLINILLVDDHMLFAKSLSIALEEYKEIEQFYSTQDIHNLSEM
                     IQDKKIDIVLMDINLRGLSECDGLKVAYNLLETNSTIKIIILTGYDLPVYKHEAKKIG
                     IYGFLNKNISPDSLIDSLLKVYQGVTCFPSENTEVIIEDLTTMEKRILQLICSGKKRK
                     IIADELYISERTLSNHLQHIYDKLDVSSSVEAITKAIKMGYISPVY"
     gene            complement(1849..3432)
                     /locus_tag="KNP36_001921"
     CDS             complement(1849..3432)
                     /locus_tag="KNP36_001921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0873795.1"
                     /translation="MTNFNLKILFLGNYILSLLFMGISTSTETYMNIQSIIPLIISTL
                     LLIDITYITSCNVRENNIISLFCGLLALDSWYLLLSFVTTPIGTIIFKILSTVIVYVS
                     IKFIFLFLFQGSGYNFRKITDILLLITCIGAIVGAFISNRTYACMYGIQFVVSIISFF
                     YIIFYHLKRVVFVIKSEKKPISISVFITIIGFLTYYFFTLRISNHIGNFGIYLTVLVF
                     FMSIHGIALKENDSFPISTVFNIKQRAIFLFISILVISLVVLFANGNFSIILIAINVL
                     FMLIFLCNIILEFNLRDEKNKVVKNSKYTFALEKLQQEEQLKTEFSNFLHDDILQNLL
                     SIKNMMSKSYRPDVQDIIYETLNNLNTCIRKQMQDYHPVILKNLTVKENYQNLIESVS
                     SSFPQKNICVSFKCSDTLFLVEPYDILIYRLIKELLTNVYKHSNGSHAWIALALEKNI
                     IKLNISDNGVANTSFKTPLDITKITFDTIKHKGIISIKEQVENLGGTISVSDNIPHGV
                     CVQITIPMKGDGSYKYFVS"
     gene            complement(3576..5603)
                     /locus_tag="KNP36_001922"
     CDS             complement(3576..5603)
                     /locus_tag="KNP36_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873796.1"
                     /translation="MNIFYTAIKNLKKNFSFYSLYLLSVSFVITVFFAFTSFSVNKIM
                     LEKISTDGRVESMCNVISIFLMAFVIFYMAYSNRFFLRRRTKELGIYALLGYRKFTIL
                     SLLTFENVLICSGAFIIGLVLGALAHKGIVFGITALLNLSIDNSQIPFFNINAINKTI
                     IFIALVVLVLAVSNGKFFYKTPLVKLIRYEKSAEKKLKFRKIPAFMGFIMILSGYCLS
                     LDILRGAKSVWVSIGFYQMGLITMIIIVIGTVLFINSFLPYIMQNSKKNKRTFYTDMK
                     IIAIPNFIYRIRSNSKTLIMLTLLSATTLTVSSVMALSLYYPIASVSRIAPSEIEFRV
                     EKNKQIEDVKQIVSQYTSNTDDIIFTQTNIYKVKSSSKDLPFEYEIGTSKNNLSNSSS
                     SKEVISRESGFECISFSDYYTLLKAQNRTKLLKQLTPLRDNECILMKYQPNNDGYSEN
                     GTIYPLLVNGKETPVAVRETSLNNAISFANSVGTLIVNDSIYEQIAQNKLPMTRILSI
                     NGKSIKNNENLYSNISDYLDGSPYLQGYSHRINDLLSINSSTFLLIGFLVVLFFIAVG
                     SILYFNNISAISDSTSDYKILQKMGYTNIQIKKIIKKQVLPFFNIPFLLGIVDCIFAT
                     LVYKTALMQNLLGNSLSQYIPVIIAIFLTSVVYLIYYILTIKSCCKIVLKK"
     gene            complement(5616..6365)
                     /locus_tag="KNP36_001923"
     CDS             complement(5616..6365)
                     /locus_tag="KNP36_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005340256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873797.1"
                     /translation="MNTILKVNNITKTYNKGQQPSLDKVSFNVSEGEFIGIMGASGSG
                     KTTLLNVLSTIDKPTSGDIFINNINLKSLNDTCAADFRKDNLGFIFQEYFLLDSLTIF
                     ENISVPLTLQKLNPDKIENMVKSLAERFGIASQLNKYPNELSGGQRQRASAVRAIVKH
                     PSILFADEPTGALDSNSATELLHSLQEANEELKTTILMVTHDAYVASFANRILIFKDG
                     HIIKELNKQQNNRHTFYELIIQEIAKLDTKR"
     gene            complement(6664..8316)
                     /locus_tag="KNP36_001924"
     CDS             complement(6664..8316)
                     /locus_tag="KNP36_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp21"
                     /protein_id="HBF0873798.1"
                     /translation="MNKKNLAILISGIMFFSSSSAIFADNTTKQERLIGKTRYETAVE
                     VSKLGWVQSKTAIIVNGNSIQSALCANPFAKLKNAPILLVNNNSIENSTKAELKRLGV
                     DNVYIVDSGNSISSKVENEIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKVENVAVV
                     NGLKGLSDAVSIASPAAIHNMPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSD
                     NTVKKYPNRERISGSDRNNTNAKIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGV
                     LAAKENSPIMISNGSLVNSQKEFIKNKDIDEITQVGGGYNQKAFEDILKLKNVNIRNK
                     TKKISLIQAKEILKQALPGSNILVCYYDEDDNEYDCKVIKDNILYEIEIDAYSGKIIE
                     IEKDDDLNDNNLGTQNISLDKAKSIALDAVPNGNLIYCKYDAEDNEYEAKVIKNKKTY
                     ELEISAFDGRIVDIDMDNDSDDDFDDNDKNNSNTNDNSSIISAEKAKSIMLDKVPGGK
                     IVKFKYDEDDKEYEGEIIKGKTEYEITINAITGKILEFEIDD"
     gene            8904..10025
                     /locus_tag="KNP36_001925"
     CDS             8904..10025
                     /locus_tag="KNP36_001925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBF0873799.1"
                     /translation="MEAKKLGFGLMRLPIKDENDVTTIDMEHLNKMVDTFLERGFTYF
                     DTAYVYHMGKSEIALRESLVKRHKRESFTIATKLPLMALKKKEEQETIFNEQLEKCGV
                     DYFDYYLLHNIGVSHYEVAKKFDSFKFIEEKKKEGKIKNIGFSFHDSAELLDKVLSEH
                     PEVDFVQLQINYLDWDNESIQSRKCYEVAEKHNKPVIVMEPVKGGTLAKIPEKAEKLL
                     NDYNPDMSISSWAIRFAASKDNVMMVLSGMSNMEQLLDNTGYMQNFKPFVQEEYNIID
                     EAVEIINESILVPCTACQYCVEGCPKNIAIPNYFALYNAEKQALNTGFSTQMVYYNNY
                     TKTYGKASDCIECKQCEESCPQHIKIIDALKNVAETFEK"
     gene            10061..10474
                     /locus_tag="KNP36_001926"
     CDS             10061..10474
                     /locus_tag="KNP36_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0873800.1"
                     /translation="MTISEVSKKYELSADTLRYYERIGLIPPVNRNKSGIRSFTEEDC
                     EWVNFIKCMRGAGLSIETLIEYVAMFQQGSSTIKARKELLIEQRNQLAKRIEEMQKTL
                     ERLNFKIDRYEEGIIEKEKVLKSSRNKKMEAVSYE"
     gene            10467..11006
                     /locus_tag="KNP36_001927"
     CDS             10467..11006
                     /locus_tag="KNP36_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0873801.1"
                     /translation="MSKNVLIVSASPRKGGNSDLLCDQFIQGVLESKNQVEKIFLKDK
                     DINYCTGCGACYEKEANCSQTDDMGEILEKMIEADVIVLATPVYFYTMNAQMKTMIDR
                     TCSRYTEICDKDFYFIVTAADENVADMERTIEGFRGFTSCLNGSKEKGIVYGVGAWNV
                     GDIKGSKAMKQAYEMGKLA"
     gene            complement(11206..11691)
                     /locus_tag="KNP36_001928"
     CDS             complement(11206..11691)
                     /locus_tag="KNP36_001928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873802.1"
                     /translation="MSKSELTAETTEEMLEVLSGKDYDIACHLHELGKSLDCKIEPKT
                     GARSYKIVYSTKKPKRSLFTIECNEKKWRVKANLFHLNTYKDAVEECSKTIKDSITKT
                     RTCKKCNSKCIGGSSFELDGKSYLTCIGSGHYFANMEEMDWKNLEKLITKENNIMQES
                     V"
     gene            12596..12973
                     /locus_tag="KNP36_001929"
     CDS             12596..12973
                     /locus_tag="KNP36_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003483933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBF0873803.1"
                     /translation="MSKVVIATEKAPGAIGPYSQAIQVGNIVSTSGQLPIDMKTGELV
                     SDPKEATKASLDNVKAILEQAGTSMDKIFKTTVFVKDLKDFNDINEVYATYFKENPPA
                     RSCVQVAQLPKDAVLEIEAMAVL"
     gene            13369..15174
                     /locus_tag="KNP36_001930"
     CDS             13369..15174
                     /locus_tag="KNP36_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0873804.1"
                     /translation="MLSKLKEFQQEMIKYTETVASVLDVDIEIVDDRLIRISGTGLYK
                     SKINESVVTEGFIYDNVIQTGQELVVLDICDNQLCIECSHYMKCLNKVIIAVPIKYNN
                     RTIGVIGAISTDKTKKVEISAKIDNYLKFVNHICDLISMKIEEHEASKNSSRKMDMMI
                     EIIENVEKGVIILDINSKISYINNIALKKLDIDKNIIENIVNIVSVESSSNGHELLEI
                     DIDNKIYNINAKIIPVYPYINQYDKIIIFDKTYINHKGHGKVNSGWGNSDIESIIGNS
                     EAMLKVKERTKKLAKSNSTVLITGESGTGKELIARAIHAEGSRWNKPFIAINCAAIPE
                     NLLESELFGYIKGAFSGASSGGKVGKFELANEGVIFLDEIGDLSMPLQAKLLRVLQER
                     KFARIGSNKLIDLDIRVIAATNKNLLKLVNEGKFRDDLYYRLNVIPINLPPLRERKDD
                     IEAIMMKFASKYSLELGIQLNKIEENVMNMLINYNWPGNIRELENAVEYMMNLVGDDG
                     IIYKDMLPLDILNYYNINGNIYKNKDVNIIFEDDIVGGIVENQERILSIKELELTYIN
                     KLLNKYGRDTKTKKKIAKDLGIGLATLYRKLEEEQ"
     gene            15251..15790
                     /locus_tag="KNP36_001931"
                     /pseudo
     CDS             15251..15790
                     /locus_tag="KNP36_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427977.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="2'-5' RNA ligase family protein"
     gene            16413..17627
                     /gene="dpaL"
                     /locus_tag="KNP36_001932"
     CDS             16413..17627
                     /gene="dpaL"
                     /locus_tag="KNP36_001932"
                     /EC_number="4.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopropionate ammonia-lyase"
                     /protein_id="HBF0873805.1"
                     /translation="MREIKWKLNNLPKSEEKEKGIEFLKDEEIAKAKAFHESFPQYEK
                     TPLVKLDNLAKSLGVSGIYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLDTDISELGY
                     DKLTSKEIKEKLGEITFFTATDGNHGRGVAWTANKLGQKSVVLMPKGSSEFRLNKIKG
                     EGADASITDLNYDDAVRLANDYAEADDHGVMVQDTAWDGYEEIPAWIMQGYGTMAKEA
                     IEQLKEYGVDRPTHVFVQAGVGSLAGAVQGYVASIYDECPITVVVEADEADCYYKSAE
                     AGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKNYSSAFVSAPDWVSAKGMRILGNP
                     LRGDEKVISGESGAVTTGALVSILESEDLKDLREALKLDENSKVLLISTEGDTDPDKY
                     RDIVWNGECQSK"
     gene            17957..19144
                     /locus_tag="KNP36_001933"
     CDS             17957..19144
                     /locus_tag="KNP36_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgeY family selenium metabolism-linked
                     hydrolase"
                     /protein_id="HBF0873806.1"
                     /translation="MLNETRKKQLTEVCQDLIRNASYSGQEENVVKAIEENFALLGFD
                     SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEARIVDGKIYGRG
                     TSDMKGQVSAMMAAVSYFAEDTNKDFEGELYVAGVVHEEIFEGVSAREISKAVQPDYV
                     VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKGINAVYKMANVIQKIQQLVPPT
                     HPVLGDGILVLTDIKSSPYPGASVVPDYCKATFDRRLLVGETREGVLAPIQALLDEMM
                     KEDPELNAKVSYAVEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDSE
                     ITQYSFCTNGSHYAGEAGIRTIGFGPSKENLAHTIDEYIELDQLFKGAEGYYGILKSV
                     YKK"
     gene            19160..20743
                     /locus_tag="KNP36_001934"
     CDS             19160..20743
                     /locus_tag="KNP36_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacylase"
                     /protein_id="HBF0873807.1"
                     /translation="MRILIKHGLIVDGNKTPAYEGDILIENEKILKISQDLNEEADKV
                     IDAKGRVICPGFIDTHSHSDLVILVNPYNEVKIRQGITTEVLGQDGISMAPLPQEHIS
                     SWRKNLAGLDGESDEIDWKYETTENYLKMMDYNGVGLNETYLVPHGNVRMEAMGLEDR
                     PATKEEIQKMCEITERELKAGAIGLSTGLIYIPCAYSLTEEIIEMCKVVAKYDGVFVV
                     HQRSEADTILTSMEEIIEIGKQSGVKVHFSHFKVCGKANWKYIPQVIELLEKAEKEGI
                     RVSFDQYPYAAGSTMLGVVLPPWAHSGGTDKLIERLSDENERAKMKKDIANGIEGWDN
                     FIEFAGIDQIFVTSVKTEKNKDTIGKNLLEIGKMRGKDPLDATFDLLKEEENAVGMVD
                     FYGLEEHIIGFMKRDEQNVCTDGLLAGKPHPRAYGSFPKILGRYVRELNVLTIEEAVY
                     KMTKKAATSFSIKDRGELKEGYFADIVIFDKDTVSGCDDFINSMQYPTGIDYVIINGN
                     CVVEEGKYNKIKAGKVLKN"
     gene            20771..22099
                     /gene="ssnA"
                     /locus_tag="KNP36_001935"
     CDS             20771..22099
                     /gene="ssnA"
                     /locus_tag="KNP36_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898311.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminohydrolase SsnA"
                     /protein_id="HBF0873808.1"
                     /translation="MILVGNGRLISQDSLNPYMEDGCVVINDNLIEDIGTTEEMKAKY
                     PVHEFIDAGKKIIMPGLINSHMHIYSSFARGMAVPGKPSENFLEILNNLWWRLDKQLT
                     LEDTKYSAYATYIECIKNGVTTVYDHHASPNAIEGSLFTISDVAKDLGIRTCLCYEVS
                     DRDGGNTIQQGINENVNFIKYAQKDDTDMIKGMFGLHAAFTLSDDTLNKCASEMAGLD
                     TGYHVHVAEGLADLQYNVDKYGKRVLERFNDFGVLKEKTIAVHCIYISAEEISLLNKT
                     NTFVVHNPESNMGNAVGCSPAIELLKRGVTVGLGTDGYTSDMFESLKVANIIHKHHLK
                     DPRVGFEESQTMLFDNNRKIAKAYYKNDLGVLKKGAYADVIVVDYIPHTPLTENTIGG
                     HTIFGMSGRSVDTTIINGKVLMKDRKLINIDEESILAKSRELSQNLWNRI"
     gene            22298..23650
                     /locus_tag="KNP36_001936"
     CDS             22298..23650
                     /locus_tag="KNP36_001936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HBF0873809.1"
                     /translation="MSRDKSPKIAPVDERLPVSKSWVFSLQHVLAMCAGAVAVPMMIG
                     SAARLDHASIVFLINACLFMAGIGTLIQSVGIGNIVGAKIPVIEGTSFAAVAGMTAIA
                     SSYSDSQVAIQTVFGSVIVAGLFCILLAPVFEKLIRFFPSVVTGTVVMVIGISLFPVG
                     IKWITDNKLEAVEPNSLALALAVLAITLLSFKFLKGIWNSTAILVGIVLGTLLSMAVG
                     MADFSAVNGVGWLNLNVPLKFGMPRFEPSAILSLCLIMLVLMTESVGNMIAIHEMVDK
                     EVTGKNIKRGLFGDGISTALSGIFNSFPITPFGQNTGIVGLTGIKSRFIAVYAGVILL
                     VLGFLPKFAAIIGAIPKPVLGGVGFAMFGMVMVGGVKTLSKVKFDGTKNGVIVAVSVG
                     LSMIPLTNPDFYHNFPTWVQTIFHSGITTGSLSAVLLNIFFNELGSKKEKNNKVEEAK
                     "
     gene            23842..24951
                     /locus_tag="KNP36_001937"
     CDS             23842..24951
                     /locus_tag="KNP36_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0873810.1"
                     /translation="MANLKVNLYGMEFLNPIMTAAGPGAKDGALCQEAAKGGAGAICT
                     KTISVLPADVPRPCMAKTNSGFLNTELWSELPKEQWIEEEYKKVKETGLPVIVSMGYS
                     AEQIAEVAPLVKPYADAVELSTHYVGTDVAPIVNALKAAKAVLDVPVFMKMSPHTDIQ
                     TIAKAVEEAGADGLVMINSFGPCMAIDVNTGYPIMGSKAGYGWLSGAPIRPLAIRCIY
                     EASQVVNIPIIGVGGITCGKDVAEMMMAGASAVQVCTEAILKGPSIYGKIAKELNEFL
                     DENGYADVNEIKGLTHKKMAARGFRTHSVAPVVDDNKCIKCKQCVTSCVYEALEVTDK
                     LNIDADKCFGCGLCVTRCPKGALSICYNQVEAMNE"
     gene            25234..26625
                     /gene="hydA"
                     /locus_tag="KNP36_001938"
     CDS             25234..26625
                     /gene="hydA"
                     /locus_tag="KNP36_001938"
                     /EC_number="3.5.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropyrimidinase"
                     /protein_id="HBF0873811.1"
                     /translation="MGIVLKGGKVVTSEKTYCADVRIEDEKIVDIGLDISKENDEIVD
                     VSDSYVIPGGIDTHTHFDLDTGVTKTADNFETGTKAAIVGGTTTILDFATQAKGCSLK
                     DGLEEWHEKAKDKSYSDYGFHMAITDWNDSVCNEMEDMVKEGVSSFKLYMAYKGSLQV
                     DDGVIFEALRKAEEIGGIIGFHCENGDIICELVDKAKSENNLSPKYHQLTRPAIMEAE
                     ATSRLMKIAEVANSKVYVVHLSCKESLEEVLKAKQRGVDVIVETCPQYLLLNDELYDL
                     DGFESAKYVMSPPLRNKENNEILWNAILDNQIDTIGTDHCSFNYKGQKELGINDFSKI
                     PNGSPGVEHRMSLLYTYGVCKNKISINKMVEVTSTNAAKLFGMYPNKGTIEIGSDADI
                     LVLNPNKKSKIEAKKQLQNVDYTPYEGYEVDCQIEHVYLRGKEVVRDGELICNTPSGR
                     YINRRLTKGAREW"
     gene            26619..29180
                     /gene="xdh"
                     /locus_tag="KNP36_001939"
     CDS             26619..29180
                     /gene="xdh"
                     /locus_tag="KNP36_001939"
                     /EC_number="1.17.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="selenium-dependent xanthine dehydrogenase"
                     /protein_id="HBF0873812.1"
                     /translation="MVEFILNGEKVVAKEGKKLLDFLREDMNITSVKNGCSEGACGTC
                     MVIIDGKATKACVFKTDKLAGKNITTIEGLSERERDVFAYSFASQGAVQCGFCIPGMV
                     ISSKALIDVNNNPTEDDIKKALKGNICRCTGYVKIIKAVDLAAKIFRENIDVPKVNCK
                     GLVGENLPRVDAVGKALGYSEYVDDMRIEGMIYGSAVRAKYPRALVKKIDIEEAKAYP
                     GVVAVLTAKDIPGTIKVGHLKKDWDTLIPEGEITRYLGDGIVLVAAETREALEEAKKL
                     VKIDYEELTPLSTTADALREDAPKIHETGNILVKEHLVRGNAKEKIENSKYVVTKRYT
                     TPATEHAFLEPECAVAGPYEDDGVIIYSTDQGVFATQHECADMLGLPYEKVRVINKMV
                     GGGFGGKEDMSVQHHAALLAYHTKRFVKVQLTRKESIIVHPKRHATEMEFTTACDENG
                     YLTGMKATIISDTGAYASLGGPVLQRLCTHAAGPYNYQDIDITGTAVYTNNPPGGAFR
                     GFGVTQSCFATECNLNLLAEMVGISPWEIRYKNAIRPGQVLPNGQFADEGTAMAETLE
                     AVKEEYEKHPRAGIACAMKNSGVGVGIPDVGRCRLVIKDGKVHIRTSASCIGQGLGTV
                     MTQVVCETANLLPENIVHEVPDTHLTPDSGNTTASRQTVFTGEATKVASNKLKEALDS
                     GKTLLDLEGEEFYGEYESITDKMGCDKENPVSHVAYGYATQVVILDENGKLEKVVAAH
                     DVGRAINPISLEGQIEGGVVMGLGYALTEDYPVVNSIPTAKFGTLGLFKSTDIPEIQA
                     LIVEKNKDLLAYGAKGVGEICTVPTAPAVQNAYYVFDKEFRTELPLQNTPYSKKK"
     gene            29332..30678
                     /gene="rpoN"
                     /locus_tag="KNP36_001940"
     CDS             29332..30678
                     /gene="rpoN"
                     /locus_tag="KNP36_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase factor sigma-54"
                     /protein_id="HBF0873813.1"
                     /translation="MNFNNSLELTQSQKLIMTTQLKQSLSILNMSKLELEEEIKREAE
                     NNPLVEVEKSGEINWEEYIKDMDRSRRLDRTEISYNPDNEVNLENLVKYSSNLYEDLK
                     FQISLYKLTDKELEVCEYIIDSLDEDGYLRTEEKVIVDTLKIDEELFEKCLISVQQLE
                     PSGVGARSLSECLMIQMASLGIYNEILEEIVTKDLNLIANNKYKEISKKYNMSLQKCV
                     ELINIIKTLDPKPGRTCSVEKSVYIQPDVTVEKIDDEFIVYLNEKDSYQIRINSYYKD
                     ILKNSQSDESAKEFIKERLNSATGLMKNIESRKTTVLKIAEEIVKAQDEFLRKGTKYI
                     KPLKMKDIAEKLEFHESTISRGVNGKYMLTPFGVYEFRYFFSSAIETENNEMASSTSI
                     KKIIKETIKDENKKKPLSDDHISKLLKEKGINVARRTVAKYREELGIPSSSKRKEY"
BASE COUNT        12049 a         3692 c         5460 g         9912 t
ORIGIN      
        1 acactattaa cttattatac ttaaaacttt aaaatgaaaa tatcaaagaa tactttttaa
       61 taaaaataat catttaataa gttatttaaa aatctaaaaa ctttacaaca aattatctat
      121 ttaaattgga ggagtgggaa tatgagtaat agtttttatc aattaaattc agcagtatta
      181 tattttaatg aaaaaagaga tgtaaataga ataaggttta atcactatgt aatgagaaaa
      241 gaaaatatac aaagattaaa aggaactctg ccaagaggac aatttatgat gacagtaagg
      301 aaagctgcat ctgaccttga tgtatctata tctacaataa gtagacttgt aaatgaattt
      361 atagatttag gtatattgag attaataagt aggggagtaa agggaaattg ttgttctgta
      421 tatagttatg tttgttctga aagtagtaat gcagaaattg taacaaagaa tggtgatatt
      481 ttcaaaaata tagagaaata cattgatgca actattaaca ataaccaaaa aacaatgaaa
      541 tataaacata gaaatgagtt gtttaagaac agtaatacca acatatacag ccgtataaat
      601 caagagagta tagacaaaga ttatgatttg ataattcata ctgggtatga aacagaaaat
      661 gagacaaaga aaaaagaatt attaaaaaat aatttaaata aaaagaattt aaataaaaat
      721 acctttgaaa attcggatga agatttgact gaagattcta cttacaaaaa tccagaaagc
      781 atacatgaaa ttattataag aaaattaaat agtgaatcag gaaaaaattt taaagctgat
      841 ttgagtataa ctaaggcact tatagataaa agattaaaag aagggtatag tttagaagat
      901 ttttacaagg ttatagaggc aaaggtaaga agatggagat atacagatat ggaaatatat
      961 atagaaccaa caattctgtt tgggtatgaa tttgagtcgt atttaaatga ggagagttct
     1021 ttatctgctt gtaattatgg tgatatgtgt tatgaagata tgtattgaga tattagttgc
     1081 tttttagttg tttaaaatat gtttatatat aaatataaat agtgtattaa aatggagttg
     1141 tctcaaaata gagagaagcc tcttcttaat tgtttaaatg atgaaaatat atttgattta
     1201 atacaaagga gagtgcttta tgagttagaa gatttatttt gagacactca ctttttttaa
     1261 tatactggag aaatataacc cattttaata gcttttgtaa tagcctcaac tgatgatgaa
     1321 acatctagct tgtcatatat gtgttgtaaa tgatttgata atgttctttc acttatatac
     1381 aattcatcag caattatttt tcttttttta ccactacaga taagctgtaa aattcttttc
     1441 tccatagtag ttaaatcttc aataattact tcagtatttt cagatggaaa acaagttacc
     1501 ccttgataga cttttaataa tgaatcaatt aaactatcag ggctaatatt cttattgagg
     1561 aatccataga tacctatttt tttagcctca tgtttataaa ctgggaggtc gtatccagtc
     1621 aagattatta ttttaatagt tgaattagtc tctaataaat tataagctac ttttaagcca
     1681 tcacattcac ttaagcctct aaggtttata tccattaaga caatgtctat ttttttatct
     1741 tgaatcattt ctgaaagatt atggatgtcc tgtgtggaat aaaactgttc gatttctttg
     1801 tattcttcta gtgcaattga caagctttta gcaaaaagca tatggtcatc aactaacaaa
     1861 atatttataa gaaccatctc ctttcatagg gattgtaatc tgtacacaaa ctccatgagg
     1921 tatattatca gaaacactta tcgttcctcc tagattttct acttgttctt taattgatat
     1981 aatccctttg tgttttattg tatcaaaagt aattttagtt atatctaaag gcgttttaaa
     2041 agatgtattt gccacaccat tatcactaat atttaatttt attatatttt tttctagtgc
     2101 taaagctatc catgcatggc taccatttga atgtttatac acatttgtca ataattcttt
     2161 aatcagtcga tatatcaata tatcatatgg ttcaactaag aataaagtat cagaacactt
     2221 aaatgaaaca caaatatttt tttgtggaaa ggatgaagaa acactttcaa ttaaattctg
     2281 ataattttct tttactgtta aattttttaa aataacagga tgatagtctt gcatttgctt
     2341 ccttatacat gtatttagat tgttaagtgt ttcatatata atatcttgaa catctgggcg
     2401 atatgactta ctcatcatgt tttttattga aagcaggttc tgtaatatgt catcatgtaa
     2461 aaaattagaa aactctgttt ttagttgttc ttcttgttgt aatttttcta atgcaaaagt
     2521 atacttgcta tttttaacta ctttattttt ttcatctcta aggttaaact ccaaaataat
     2581 gttacagagg aaaatgagca taaataaaac atttatagct attaatatta tagaaaaatt
     2641 cccattggca aatagtacga ccaagctaat tactaaaata cttataaaaa gaaatatagc
     2701 cctttgtttt atgttaaaaa ctgttgaaat aggaaaacta tcattttctt taagtgcaat
     2761 accatgaata ctcataaaaa ataccagtac agttagatag attccaaaat taccaatatg
     2821 atttgatatt cttagtgtaa aaaaataata agtaaggaat cctataattg ttataaatac
     2881 tgaaatcgat ataggttttt tttcgctttt tatgacaaaa acaacccttt tcaaatgata
     2941 aaaaataata tagaaaaagc ttattatact aacaacaaac tgtattccgt acatacaagc
     3001 atacgttctg ttagaaataa atgctcctac aattgcacca atgcaggtga taagcaataa
     3061 aatgtctgtt atcttacgga aattgtatcc actaccttga aacaaaaata aaaatataaa
     3121 tttaatagag acatacacta taactgtgct taatatttta aaaataatag tgcctattgg
     3181 tgtggttaca aatgataaga gtaaatacca actgtctagt gctagtaatc cacaaaacaa
     3241 tgaaataatg ttattttctc ggacattaca agaggttata tatgtgatgt ctatgagtaa
     3301 taatgttgaa attattaagg gaataatgct ttgaatattc atataagttt cagtgcttgt
     3361 agatattccc atgaagagaa gtgatagaat gtagtttcct aaaaatagta tttttaaatt
     3421 aaaatttgtc aatcttatac acctccttat gagttaatta tattaatttt atgactaaat
     3481 caaacttaag aatttatagt tttaaattat atcaaatact tataaatgaa gtataccaaa
     3541 tcgtcacacc tttaagcttg acgatttggc aaatattatt tttttaatac aattttacaa
     3601 caggatttaa tagtaagtat gtaatatatc aaatatacta cagaagttaa gaaaattgca
     3661 ataatcacag gtatgtattg tgaaagtgaa tttccaagta aattctgcat caaagcagtc
     3721 ttataaacca aggtagcaaa tatacagtcc actataccaa gtaaaaacgg aatattaaaa
     3781 aatggcaata cttgtttttt aataattttt ttaatttgta tattagtata acccattttc
     3841 tgtaaaattt tataatcaga tgttgaatct gaaattgctg atatattgtt aaagtataaa
     3901 atacttccaa cagcaataaa gaataatacc acaagaaatc cgattaacag aaatgtagaa
     3961 ctattaattg ataataaatc atttatcctg tgagaatatc cttgtaaata agggcttcca
     4021 tctaaataat ctgaaatatt actatataaa ttttcattat ttttaattga tttaccatta
     4081 atacttaaaa ttcttgtcat tggtaattta ttttgtgcta tttgctcata tatactatca
     4141 ttaacgataa gtgttccaac gctattggca aaagaaatag cattgtttaa tgatgtttcc
     4201 cttacagcta caggtgtttc tttaccatta acaagtaatg gataaatcgt tccattttca
     4261 ctatatccat cattatttgg ttgatatttc attaaaatac attcattatc ccttaaaggg
     4321 gtaagttgtt ttagtagctt tgttcgattt tgtgccttta ataaagtata ataatcagaa
     4381 aaagatatac attcaaatcc tgattctctt gaaataactt ctttagaaga actactattg
     4441 gataaattat tcttagatgt accaatttca tattcaaatg gaaggtcttt tgatgaagat
     4501 tttaccttat aaatatttgt ctgtgtaaaa ataatatcat ctgtattaga cgtatattga
     4561 ctgacaattt gttttacatc ttctatttgt ttattttttt ctactctaaa ttctatctct
     4621 gaaggtgcaa tacgcgaaac agatgcaata gggtagtata aggacagtgc cataacactt
     4681 gaaactgtca aagtagtagc agagagtaat gtaagcataa ttagagtttt agagtttgaa
     4741 cgtatacgat agataaagtt tggaatagct attatcttca tatctgtgta gaaagtacgt
     4801 ttattttttt tactattttg cataatatat ggaagaaagg aattgataaa gagaactgta
     4861 ccaattacaa tgataatcat agttatcaag cccatttgat aaaatccaat acttacccat
     4921 actgatttag ctccacgaag aatatctagt gataaacaat acccgcttaa aatcataata
     4981 aaccccataa aggctggaat ttttctgaac tttaattttt tttctgcact tttttcatat
     5041 cttatcaatt ttacaagtgg agtcttataa aaaaatttac catttgatac agctaagact
     5101 aaaacaacta atgctataaa gataattgtt ttatttattg catttatatt aaaaaatggt
     5161 atctgtgaat tatcaattga taaattaagt agtgctgtaa ttccaaagac aataccctta
     5221 tgtgccaatg ctcctaatac caatccaata ataaaagctc cactacaaat taatacattt
     5281 tcaaaggtaa gtagcgataa tattgtaaac ttacgatagc caagtaaagc atatatacct
     5341 aattcttttg tacgacgtct caagaagaat cgatttgagt atgccatata gaagatgaca
     5401 aatgccatca aaaatatcga aataacatta cacatagatt caactctacc atcagttgaa
     5461 attttttcta gcattatctt attaacagaa aatgaagtaa atgcgaaaaa tacagtaata
     5521 acaaaagaga ctgaaagtag atatagagaa tagaatgaaa agtttttttt aagattcttt
     5581 attgccgtat aaaaaatgtt cattaaatta tcctcctatc ttttagtatc caattttgca
     5641 atttcttgaa taatcaactc ataaaatgta tgtctattat tctgttgttt atttaattct
     5701 ttaatgatat gaccatcttt aaaaatcaaa attctatttg caaaacttgc tacataggca
     5761 tcatgtgtta ccattaaaat tgttgttttc aactcctcat ttgcttcctg tagtgagtgg
     5821 agtagttcag tagctgaatt agaatccaaa gctcctgttg gttcatctgc aaagagaata
     5881 ctaggatgtt ttactattgc tctaactgct gaagctctct gtctttgccc accagataat
     5941 tcatttgggt atttatttaa ttgagaagct atgccaaatc gttcagctag actctttacc
     6001 atgttttcta ttttatctgg attgagtttc tgaagtgtaa gaggtactga aatattctcg
     6061 aaaattgtaa gactatctag taaaaaatac tcttgaaaga taaagcctaa attatcctta
     6121 cgaaaatcag cagcacaagt gtcattaagc gatttcaaat ttatattatt tatgaaaata
     6181 tctccacttg ttggtttatc aattgtagat aatacattaa gtagagttgt tttcccagag
     6241 ccagaagctc ccattatacc tataaattca ccttctgata cattaaagga taccttatct
     6301 aaactcggct gttgcccttt attataagtt ttagttatgt tatttacttt taatattgta
     6361 ttcattgtat atgtctcctt tcgtcttaat atagtcaaat tatatattaa ccttattgtt
     6421 tcttcatgag taaatcacgc aataattcta cacaaattac ttatatcaca atatattgtt
     6481 taaaatctaa ctttattagg tttgggatga tggacaagat tttaatttaa aagagtgcat
     6541 aggtatatat aatggcataa tgtggattta aattaaaaaa aataaaataa agccataaat
     6601 attgaaattt tcaatattta tggctttatt gcttgtaata attaatagaa tatatatttt
     6661 ttattaatca tctatttcaa attctaatat tttaccagta attgcattaa ttgttatctc
     6721 atattcagtt tttcctttta ttatttcacc ttcatattct ttgtcatctt catcatactt
     6781 aaattttact attttcccac caggcacttt atctagcatt attgatttag ctttttcagc
     6841 actaataata gaactgttgt cattagtatt agagttattc ttatcattat catcaaagtc
     6901 atcatcagaa tcattgtcca tgtcaatatc tacaattctt ccatcaaatg cacttatctc
     6961 taattcatat gttttcttat tttttattac tttagcctca tattcgttat cttcagcatc
     7021 atatttacaa tagattaaat taccattagg aacagcatct aatgctatag acttagcttt
     7081 atccaatgat atattttgtg tacctaaatt attatcattt aagtcatcat ctttttcaat
     7141 ttctattatt ttaccagagt aggcatcaat ttctatctca tataggatat tatcctttat
     7201 aactttgcag tcatattcat tatcatcttc atcataataa caaactaaaa tattgcttcc
     7261 tggaagagct tgttttaata tttctttagc ctgtattaaa gatatttttt tagttttatt
     7321 tcttatgttc acatttttta gttttaaaat atcttcaaat gctttttgat tatatcctcc
     7381 tcctacttgt gttatttcat ctatatcttt atttttaata aattcttttt gactatttac
     7441 aaggctacca ttagatatca ttataggaga attttcttta gcagctagta ctcctattga
     7501 taatgaatct actaatgcat tttcttggtt aataccatct ttagctacaa atacattatt
     7561 tattttttta tctttataaa atttatcaat aatttttgca ttagtattgt ttctatctga
     7621 accactgatt ctttctctgt ttggatattt ctttactgta ttgtctgata aaatcttatt
     7681 tcctccaact atgtaagatt tttttataga cctattgttt aagaaattta tactactatc
     7741 attgctgttt tcatctgata ctaatattat aggcatatta tgtattgctg ctggagaagc
     7801 tatactaact gcatcagata gtccctttag tccatttaca actgcaacat tttctacctt
     7861 ttttatctta tctatttctt taagtacatt tgtagacatt tcatatatat tgtttcctac
     7921 tattttattt atttttatgt taagtgattt tatttcattt tctactttag aagaaatgct
     7981 atttccacta tctacaatgt acacattatc tacaccaagc cttttaagct cagccttagt
     8041 tgaattttca atactgttgt tgtttactaa aagtataggt gcattcttta gcttagcaaa
     8101 tggatttgca caaagcgcac tttgaataga attaccatta actataatgg ctgtttttga
     8161 ttgaacccat cccaatttac ttacttctac tgctgtttca tatcttgttt tacctattaa
     8221 tctttcttgc tttgtagtat tgtctgcaaa aattgctgaa gaactagaaa aaaacataat
     8281 acctgatatt aatatagcta aatttttctt attcatattt ttacctcaca atctttaaaa
     8341 atttgttatt tagcatactt aataaaatat aatcttaaaa tcaaattgat gctgagtttg
     8401 aagttacaaa atcaacaaat aagatttttt taatacaaaa ttttcctttt tatatttaac
     8461 attgtatcac aaatataaaa aggaaaaaac tttttaaaaa gggtatacac tattcatttt
     8521 ttatcttata aataagtctt taccactgtt ttatatattt taaaatagac acaagaccta
     8581 tttctaaatc ttttaggtga aatttctttt taaacatatc taaaaagtat ttgtagtaat
     8641 attaatggac tgaatttctt aaagtatata tttctttaca tgttggagtt tgtgaagttt
     8701 gagaattgga gggtgaaaga aacatgtaat ggattaatat taaagaactg tatttttata
     8761 atatttgtct taaaaataaa aaaatctatt gacttgaagt taactccaag tagtaaagta
     8821 taattataca agaattatat acttgtaaga atagttaaag tagagagaaa aaacaaacaa
     8881 gttttaaagg gggaagtaaa acaatggagg caaaaaaatt aggatttgga ttaatgcgtt
     8941 taccaataaa agatgaaaat gatgttacaa ctattgatat ggaacattta aataaaatgg
     9001 tagacacttt tttagaaagg ggatttacat attttgatac agcctatgtg tatcacatgg
     9061 gaaaaagtga gatagcactt agagaatctc tagtaaaaag acacaaaaga gagagtttta
     9121 ctatagctac aaaacttcca ttaatggctt taaagaaaaa agaagagcaa gaaaccattt
     9181 ttaatgagca attagaaaaa tgtggtgtag actattttga ctactatctt ttacacaata
     9241 taggcgtgtc acattatgaa gtagctaaaa aatttgatag ctttaagttt attgaagaaa
     9301 agaaaaaaga aggaaaaata aagaatattg gtttttcttt tcatgatagt gcagaattat
     9361 tggataaagt cttgagtgag catccagaag tagacttcgt gcaattacag attaattatt
     9421 tagattggga taatgaaagc atacaatcta gaaaatgcta cgaggtggca gagaagcata
     9481 ataagcctgt aattgttatg gagccagtaa aaggaggtac acttgcaaag ataccagaaa
     9541 aagcagagaa attattgaat gactacaatc cagatatgtc aatttcatct tgggcaatac
     9601 gttttgcagc aagtaaagat aatgttatga tggtcttaag tgggatgtca aatatggaac
     9661 aattattaga caatacagga tatatgcaaa atttcaaacc attcgtacaa gaggaatata
     9721 atattataga tgaagcagta gagattatca acgaatcaat tttagttcct tgtactgcct
     9781 gtcagtattg tgtagaaggc tgtccaaaaa atatcgctat tccaaactat tttgcgttgt
     9841 acaatgcaga aaaacaagct cttaatactg gattttcaac acagatggtc tactataata
     9901 attatactaa aacttatgga aaggcctcag attgtattga atgtaaacaa tgtgaagaaa
     9961 gctgtcctca acacattaaa attatagatg ctttaaagaa tgtagcagaa acctttgaga
    10021 aataattcaa tctatacaat atcaagagga gaagatatgt atgacgattt cagaagttag
    10081 taaaaaatac gagctttcag cggatacttt acgatattat gaacgaattg gtttaatacc
    10141 acctgtaaat agaaataaaa gtggaattag gtcttttaca gaagaagatt gtgagtgggt
    10201 taatttcata aagtgtatga gaggtgcagg tctttctatt gagacattaa ttgagtatgt
    10261 agctatgttt caacaaggga gcagtactat caaagctaga aaagaacttt taatagagca
    10321 gagaaaccaa ctagcaaaaa gaatagaaga aatgcaaaaa actttggaac gattaaattt
    10381 taagattgat agatatgaag aaggtattat tgagaaagaa aaagtattaa agagcagtag
    10441 aaataagaaa atggaggcag tatcttatga gtaaaaatgt attaatagta tcagctagtc
    10501 ctagaaaagg tggaaattct gatttattgt gtgaccagtt tatacaaggg gtattagaat
    10561 ctaaaaatca agtggagaag atatttttaa aagataaaga tattaactat tgtactggat
    10621 gtggtgcttg ttatgaaaaa gaagcaaatt gttcacagac agatgacatg ggagaaattc
    10681 ttgaaaaaat gattgaggca gatgtgattg ttttagcgac tccagtttat ttttatacta
    10741 tgaatgcgca aatgaaaact atgattgata gaacttgctc tagatatact gaaatttgtg
    10801 ataaagattt ctattttatc gttacagcag cagatgaaaa tgtggctgat atggaaagaa
    10861 caatagaagg atttagagga tttacatcat gtctaaatgg ttctaaggaa aaaggtatag
    10921 tatatggtgt aggtgcttgg aatgtaggtg atattaaggg aagtaaggca atgaaacagg
    10981 catatgaaat gggtaagttg gcgtagtatg tttgtataaa attgtataaa attgaatata
    11041 ttcttatcat ttcaacaata aaaagaggct tatctgtatt ttgagacagc ctctttgtgc
    11101 tatatcattt atttttattc tatatcctta ttataccctt tattttttta tgcctattta
    11161 agtatctgtt gttactcata tattttaata attaccctta aaaaactata cagattcctg
    11221 cataatatta ttttctttag taattaattt ttctaggttt ttccaatcca tttcttccat
    11281 atttgcaaaa taatgaccac ttcctatgca agtcaggtaa gactttccat ctaattcaaa
    11341 cgaagaacct ccaatacact ttgaattaca tttcttacaa gtacgagttt tagttatact
    11401 atctttaata gttttagagc attcctccac agcatcttta tatgtattta gatgaaaaag
    11461 atttgcttta actctccatt ttttttcatt acattcaata gtaaataagc tacgttttgg
    11521 tttcttagtt gaatatacta ttttgtaaga acgagcacct gtttttggtt caattttaca
    11581 atctaatgat ttaccaagtt catgtaaatg acatgcaata tcataatctt taccacttag
    11641 tacttctaac atttcttctg ttgtttctgc tgttaattca cttttgctca tattaaaaaa
    11701 atccccctat ataaataata atttcatatg aaaataatta atataagtat attaaataaa
    11761 actattaaaa tcaataaaat tactgcaatc ttacattatt gggcatagaa tgagagctaa
    11821 tgatttatta gaaataagac ttaatagtat gaaaatttac ttagacgtgg tacaattcta
    11881 taaaagattt aaaactagga aaggagaaag ttgttgagat acggccaata taacaattta
    11941 tttataagtt gtaaatttat tatgagatta attagattgt taagtaatac tatcaaaagg
    12001 tagttttttg gattttcagc aacagtggta gatattgata attttttggt tattattata
    12061 tttagctgtt atattttcaa taggctctat gataactagg gtaaataagg tatgggtaaa
    12121 ggttttatta tttataatag tgggattgtc aactatagtt ctttcatatg taataacttg
    12181 attatgcaaa attctatgaa gcaggaaccc tgtgacttta gtcatgggag gttcagaatt
    12241 taaggttaaa aaataacttt aatctgtaaa ttctcaaaac aagaattctc atgttggtaa
    12301 atttctagat atgagaaaaa aattgacatc ataaaaaagt aattttagag cgttttttta
    12361 cgaaaaaatt cagaagtaac tattttgaat gacttcacaa aattttatat ataaataaag
    12421 tttggcacgt taattgcttt aataaaagtt aacaagacac aaataaacat aatcatctaa
    12481 gtattgatta tttgaagttt tagatttgaa gtttaatcta aaggttcgta ttaatattgg
    12541 tgtttaggaa attttatttt cctgtaaata taacttaata ataggaggtg aagtcatgtc
    12601 aaaagtagta atagctacag agaaagctcc aggagcaatt ggaccatatt ctcaagcaat
    12661 tcaagttgga aacatagttt ctacatcagg tcaacttcca atagatatga agactggcga
    12721 gttagtatct gacccaaaag aagcaacaaa agcttcttta gataatgtaa aagcaatatt
    12781 agaacaagct ggtacaagta tggataaaat atttaagact acagtattcg taaaagattt
    12841 aaaggatttt aatgatatta atgaagtata tgctacatat tttaaagaaa atccaccagc
    12901 aaggtcatgt gtacaagttg ctcaattacc aaaagatgca gttttagaaa ttgaagcaat
    12961 ggcagtatta taagtattat aacaataaaa ccaataacaa aactaataaa aattaaaaac
    13021 taataaaaaa agtctacaat taaaaaagtt tatattaaaa aagtctatat aaaaatctat
    13081 ctaaatattt aactattgag cttttctcat ataatgtata tttttatgtc aaaaatatat
    13141 ttgttatatg aggaaagctt ttttttatta ttgtattgtg atttatttta ttgtctgcat
    13201 attataatta aggttactat ataaaacaaa ctttttataa attaatattg tctgttttaa
    13261 cgcaaatata taaataagta atgttttata tatattttaa agagtgacta tatgttaaaa
    13321 tatagctaaa ctgataattt ggtaaattaa attctaatgg gggaaactat gttaagtaaa
    13381 ttaaaagaat ttcaacaaga aatgataaaa tacactgaaa cagtagctag tgtgttagat
    13441 gtagatattg aaatagttga cgatagatta ataagaatta gtggtacagg tctgtataaa
    13501 tcaaagataa atgaaagcgt tgttactgag ggctttattt atgacaatgt tatacagaca
    13561 ggtcaggaat tagtcgtatt ggatatatgt gataatcagc tttgtataga atgttcccat
    13621 tacatgaaat gcctaaataa agtaataata gcagttccaa taaagtataa taatcgaact
    13681 ataggagtaa ttggtgctat tagtacagat aaaactaaaa aagtagaaat aagtgcaaaa
    13741 atagataatt atttaaaatt tgtcaatcat atatgcgatt taatttctat gaaaatagaa
    13801 gaacatgaag cgtcaaaaaa tagcagtaga aaaatggata tgatgataga aatcattgaa
    13861 aatgttgaaa aaggcgttat aatactagac ataaatagca aaatatctta tataaacaat
    13921 atagctctaa aaaaattaga tatagataaa aatataatag aaaatatagt aaatatagta
    13981 tctgttgaat cttcctcaaa tggacatgaa ttactagaaa ttgatattga taacaaaatt
    14041 tataatataa atgccaaaat aattccggta tatccatata taaatcaata cgacaaaata
    14101 ataatatttg acaagacata tatcaatcat aaaggacatg gaaaagtgaa tagtggctgg
    14161 ggaaatagtg atatagagtc tataattgga aattcagaag caatgttaaa agtaaaagag
    14221 agaactaaga aattagcaaa gtcaaattca actgtactta taactgggga aagtggtacg
    14281 ggtaaagagc taattgctag ggctatacat gctgaaggta gcagatggaa caagccattt
    14341 attgcgataa actgtgctgc tattccagaa aatctccttg aaagtgagct atttggctat
    14401 ataaaaggtg catttagtgg agctagtagt ggaggtaaag taggtaaatt tgaacttgca
    14461 aatgaaggtg ttatatttct tgatgaaata ggagatttgt caatgccttt acaagcaaag
    14521 ttacttagag ttttacaaga gagaaaattt gcgagaattg ggtcaaataa acttatagat
    14581 ttagatataa gagtgattgc tgctacaaat aaaaacttat tgaaattagt aaatgaaggt
    14641 aagtttaggg atgatttata ctatagattg aatgtaattc ctataaattt gccacctctt
    14701 agggaaagaa aggatgatat tgaggcaata atgatgaagt ttgcttctaa atattcttta
    14761 gaattaggta ttcagttaaa taaaatagaa gaaaatgtaa tgaatatgtt gattaactat
    14821 aattggccgg gaaatataag ggaactggaa aatgcagttg aatatatgat gaatttggtt
    14881 ggagatgatg gaataatata taaagatatg cttccattag atattttaaa ctattataat
    14941 attaatggaa atatttataa aaataaggat gtaaatataa tatttgaaga tgatatagtt
    15001 ggagggatag tagagaatca agaaaggata ctttcaatta aagaattaga gttgacttac
    15061 ataaacaagt tgttgaataa gtatggaaga gatacaaaga cgaagaagaa gatagcaaaa
    15121 gacttaggca taggtttggc tacactatat agaaaattgg aagaggaaca gtagtaatat
    15181 aatattaaaa tgataggtat ttgtgtgttt ttatagatag gtatttttac tttatggtgg
    15241 aggtgttatt atgcaatatg cgatagagct gtattatgat aaaaaaacgg aaaagcaact
    15301 ttttgattta tctaaaaaaa tcgctgatga aaaaattagt acgaagtatt tagaatggaa
    15361 aacaagacct catcttactt tggcttgttt caatgatgtg gatgaggctt gttgtataga
    15421 caagctaaag gggtttgcac aaaaccataa ggtaatacct gcttacattg gttcagtagg
    15481 catgtttaat gatactaaaa cggtgtttgt atcacctata atgaatagca gtatgtagca
    15541 gtttcagaga gaattatatg aggtactaca agattttgat tcaaatggtt gggaatggta
    15601 ccaccccaat cgttgggtac cccattgcac aatagcactt actggagatg atgaaagtga
    15661 ggcttttttt cgggcaagtg atgtattact gcgtgagttc aaaaaaataa gtggtgagtt
    15721 tgtctcaata ggattggtta aaattacatt tcctgtggaa gaaattttta cagtgaatat
    15781 gaataggtaa ctttaactct gttgtggatg ttatgaatat tttgtatagt gcatttcatc
    15841 agataaatgc gaagttgcga atttcgacag ctcaatagtc gcaagtaggg cacaatggta
    15901 cacatattgc acttttgctt attgggggga cgcccatgta aacttctgta agaagctatg
    15961 aaaagattta agccattttg gaggctttgg gtaataaaga atatttgggt aataaagaat
    16021 ataaagtata taaatttata gagtttatgc gtaagaaggt tatagccata tatttataga
    16081 aaataaaagt agtaatatat ctgacaaaac aatagacata taaaaaataa gagcataata
    16141 aaggaagaat taagataaat aaacgatttc tcgaattgat aattctcgta ttgataaaaa
    16201 tttcccaata tgagaatttt ttcttttata aatcttattt ttcacactca aaatttataa
    16261 actttaaaga aattttataa aagtatgtaa ttccaacata aaaaaattgt ttttagaata
    16321 aataatattg gcacggtaat tgctttgcta taaggcacaa agataaaaaa ttaaaatgac
    16381 accgaaaaat ttgaaagggg aatataaaat aaatgagaga aataaaatgg aaattaaata
    16441 acttacctaa atcagaggaa aaagaaaaag gaattgaatt tttaaaagat gaagagattg
    16501 caaaggctaa agcttttcat gaaagctttc cacaatatga aaaaactcct ttagttaaat
    16561 tagataactt agcaaaatca ctaggcgtaa gcggaatata tgttaaagac gaatcttata
    16621 gatttggttt aaacgcattt aaagttttag gtggttctta ctctatgggt agatacttag
    16681 ctcaaagatt agatacagat atatctgagt tagggtatga taaattaact tcaaaagaaa
    16741 taaaagaaaa attaggagaa ataactttct ttacagctac agatggaaat catggtagag
    16801 gagttgcttg gacagctaat aaattaggtc aaaaatctgt tgtattaatg ccaaaaggtt
    16861 cttctgaatt tagattaaat aaaatcaaag gagaaggtgc agatgctagt ataacagact
    16921 taaactatga tgatgcagta agattagcta atgattatgc agaagctgat gaccatggag
    16981 taatggttca agatacagca tgggacggat atgaagaaat accagcatgg ataatgcaag
    17041 gatatggaac tatggctaaa gaagctatag aacaattaaa agaatatgga gtagatagac
    17101 caacacacgt atttgttcaa gcaggagttg gttcacttgc tggtgcagtt caaggatatg
    17161 ttgcttcaat atatgatgaa tgcccaataa cagtagtagt agaggctgat gaggctgact
    17221 gttactataa atcagcagaa gctggagatg gaaaaccaag atttgttgga ggagatatgc
    17281 caactataat ggcagggctt gcttgtggag aaccaaacac tataggtttt gaagtgttaa
    17341 aaaattattc atcagcattc gtttcagcac cagactgggt atctgctaaa ggtatgagaa
    17401 tattaggaaa ccctctaaga ggagatgaga aagtaatctc tggagaatct ggagcagtta
    17461 caactggagc attagtttca atccttgaaa gtgaagattt aaaagactta agagaagctt
    17521 tgaaactaga tgagaactct aaagtattat taataagtac agaaggagat actgaccctg
    17581 ataaatatag agatatagtt tggaatggtg aatgccaaag taaataaaag acttaaggaa
    17641 aagaaaatct taacaaataa atgaaaaatt taaggaaaat aaaaacttaa ataagtgaaa
    17701 actttaaata aaataaaaac taaaacaaat gaaaaatcta aataaatgaa aaagtaaagc
    17761 aaataaaaaa gtaaagcaaa tgaaaaattc aaaataaaaa ccaaataaaa ttaaaataaa
    17821 gtctaaataa aaatttaata aataaaatat aaagaaataa aaaatcaata gattaagtga
    17881 aatgctaata aattaaaaaa atgaaatatc aaaataaaac gtcaacaaat taaaaattat
    17941 atgggggaat atcaaaatgt taaatgaaac aagaaaaaaa caattaactg aagtatgcca
    18001 agacttaata agaaatgcta gttattcagg tcaagaagaa aacgtagtaa aagctataga
    18061 agaaaatttt gctttactag gttttgatag ttggtcaaga gatagatatg gaaatatagt
    18121 aggatgtata aaaggaaata aaccaggtaa aaaaatatta tttgacgggc atatagatac
    18181 agttccagtt ccagatgcaa gtaaatggag tgttcctcct tttgaagcga gaatagtaga
    18241 tgggaaaata tatggtagag gaacttctga tatgaagggg caagtaagtg ctatgatggc
    18301 tgctgtttca tactttgcag aagatactaa caaagacttt gaaggtgaat tgtatgtagc
    18361 aggtgttgtt catgaagaaa tatttgaagg tgtttcagct agagagataa gtaaggctgt
    18421 tcaacctgat tatgttgtaa taggtgaatc ttcagaatta aacctaaaga taggtcaaag
    18481 aggtagagga gaaatagtag tagaaacttt tggtaaacca gctcactctg ctaatccaga
    18541 aaaaggtata aatgcagttt ataaaatggc taatgtaatc caaaagatac aacaattagt
    18601 acctccaact catccagttt taggtgatgg aatattagtt ttaacagata taaaatcttc
    18661 tccatatcca ggagcatcag tagtgccaga ttattgcaaa gctacttttg atagaagatt
    18721 attagttgga gaaacaagag aaggcgtatt agctccaata caagctttat tagatgaaat
    18781 gatgaaagaa gacccagaat taaatgcaaa agtttcttat gcagttgaaa aagctgattg
    18841 ctatacagga aatactatag aaagtgaaag attcttccca ggttggctat atgatgaaga
    18901 agatgaattt gttcaagcag cgtataaggg attaaaagaa gctggaatag attcagaaat
    18961 aactcaatac tcattctgta cgaatggaag tcactacgca ggtgaggctg gaataagaac
    19021 tataggattt ggtccttcta aggaaaatct tgctcataca atagatgagt atatagaatt
    19081 agaccaatta ttcaaaggtg cagaaggata ttatggtata ttaaaatcag tttataaaaa
    19141 ataattagga gatggttttg tgagaatttt aataaaacat gggcttatag tagatggaaa
    19201 taaaacacca gcatatgaag gagatatttt aatagaaaac gagaaaatat taaaaatatc
    19261 acaagattta aacgaagaag ctgacaaagt tatagatgca aaaggtagag ttatatgtcc
    19321 aggtttcata gatactcata gccattcaga cctagttatt ttagttaatc catataatga
    19381 ggtaaagatt agacagggaa ttacaacaga agtgttgggc caagatggta tatctatggc
    19441 ccctctacct caagagcata tatcttcttg gagaaaaaat ttagcaggtc tagatggtga
    19501 aagtgatgaa attgattgga aatatgaaac aacagagaat tatttaaaaa tgatggatta
    19561 caatggggta ggtttaaatg aaacttattt agtacctcat ggaaacgtta gaatggaagc
    19621 tatgggactt gaagatagac ctgctactaa agaagaaatt caaaaaatgt gtgaaatcac
    19681 agagagagaa ttaaaagcag gagctatagg attgtctact ggacttatat atataccttg
    19741 tgcatactca ttgactgaag aaattataga gatgtgtaag gtagtagcaa aatatgatgg
    19801 agtatttgta gttcaccaaa gaagtgaagc agatacaatt ttaacttcaa tggaagaaat
    19861 catagaaatt ggaaaacaat caggagtaaa agttcatttt tcacatttta aggtttgtgg
    19921 taaagcaaac tggaagtata taccacaagt tatagagctt ttagaaaaag cagaaaagga
    19981 aggaataaga gtatcttttg accaatatcc atatgcagca ggaagtacaa tgcttggagt
    20041 agttttacct ccttgggcac attctggagg aactgataag ttaatagaaa gattaagtga
    20101 tgaaaacgaa agagcaaaaa tgaaaaaaga tatagcaaat ggaatagaag gctgggataa
    20161 ttttatagaa tttgctggaa tagaccaaat atttgtaaca agcgtaaaaa cagaaaagaa
    20221 taaagataca attggtaaga acttattaga aattggaaaa atgagaggaa aagacccatt
    20281 agatgcaacg tttgatttat taaaagaaga agaaaatgca gttgggatgg tagatttcta
    20341 tggattagaa gaacatataa taggattcat gaaaagagac gagcaaaatg tgtgtacaga
    20401 tggtctttta gcaggtaaac cacatccaag agcttatggt tctttcccta aaatactagg
    20461 aagatatgtt agagagttga atgtgttaac aatcgaagaa gctgtttata aaatgactaa
    20521 aaaggcagct acaagcttta gtataaaaga tagaggcgaa ttaaaagaag gatattttgc
    20581 agatatagtt atatttgaca aggatacagt tagtggttgt gatgatttta tcaactctat
    20641 gcagtaccct acaggtatag attacgtaat tataaatgga aattgtgttg ttgaagaagg
    20701 aaaatacaat aaaattaaag caggaaaagt acttaaaaat taaatcttag ctttaaggag
    20761 gaataaattt atgattttag tggggaatgg gaggctaata agccaagatt ctttaaatcc
    20821 ctatatggaa gatggatgtg tagtaataaa tgataatcta attgaagata taggtactac
    20881 agaagaaatg aaagctaaat atccagtaca tgaatttata gatgcaggca agaaaataat
    20941 catgccgggt ctaataaatt cacatatgca tatatacagc tcatttgcta gaggaatggc
    21001 agttccagga aaaccttctg agaacttttt agagatacta aacaatttat ggtggagact
    21061 tgacaaacag cttacactgg aagatacaaa atacagtgca tatgcaacgt atatagaatg
    21121 tataaaaaat ggtgtaacaa cagtttatga ccatcatgca agtccaaatg caattgaagg
    21181 cagtttgttt acaatatcag atgttgcaaa ggatttggga attagaacgt gtctttgtta
    21241 tgaagtgtct gatagagatg gtggaaatac aatccaacaa ggtatcaatg aaaacgtaaa
    21301 ctttataaaa tacgctcaaa aagatgatac agacatgata aaaggaatgt ttgggcttca
    21361 tgctgcattt acactatctg atgatacatt aaataaatgt gcttcagaga tggctggtct
    21421 tgatacaggt taccatgtac atgttgctga aggactagca gacttacaat ataatgtaga
    21481 taaatatgga aaaagggttt tagaaagatt caatgatttt ggagtactaa aagaaaaaac
    21541 aatagcagtt cattgtatat atataagtgc agaagaaatc agtcttttaa ataaaacaaa
    21601 tacatttgta gttcataatc cagaatctaa tatgggaaat gcagttggat gttctcctgc
    21661 aatagagtta ttaaaaaggg gagttacagt aggattagga actgatggat atactagcga
    21721 tatgtttgaa tcattaaaag ttgccaatat aattcacaaa catcacttaa aagacccaag
    21781 agttggattt gaagaatcac aaacaatgtt atttgataac aatagaaaaa tagctaaagc
    21841 ttattataaa aatgacctag gagtacttaa aaaaggtgct tatgcagatg ttatagtagt
    21901 tgattatata ccacatactc cattgacaga aaatacaata gggggacaca ctatttttgg
    21961 aatgagtgga agaagcgtag atacaactat tataaatgga aaggtactta tgaaagatag
    22021 aaagttaata aacatagatg aagaaagtat tctagcaaaa agtagagaat taagtcaaaa
    22081 tctatggaat agaatttaaa taattgatta tgcaaaattc tatgaagcag gaaccctgtg
    22141 actttagtca tgggaggttc agattaatat acaagtaaga aacaagaatt tagatgttaa
    22201 aaacagagct taaacaaaaa taggaattta aatgaagtat ataaataaaa aatatacgga
    22261 atagaatatt aaattaaata tagaagggag acccaaaatg tctcgagata aaagccctaa
    22321 aatagctcca gtagatgaaa ggttacctgt atccaaatct tgggtatttt cactacagca
    22381 cgttttagca atgtgtgcag gagcagtagc agttcctatg atgataggaa gtgctgcacg
    22441 actagatcat gctagtattg tttttttaat aaatgcttgc ttgtttatgg caggtatagg
    22501 aacactcata caaagtgttg gtataggaaa tattgtaggt gctaaaatac cagtaataga
    22561 aggaactagt tttgccgctg tggcaggtat gacagcaata gcctcatcat atagtgattc
    22621 acaagttgca atacagacag tatttggctc tgtaatagta gctggattgt tttgtatatt
    22681 acttgctcca gtatttgaaa aattaataag atttttccct agtgtagtta ctggaacagt
    22741 tgttatggta ataggtattt cactatttcc agttgggata aaatggataa ctgacaacaa
    22801 attggaagcg gttgaaccaa actcattagc attagcttta gcagtattgg caataacttt
    22861 actttcattt aaattcttaa aaggaatttg gaatagcaca gctatattgg taggtatagt
    22921 acttggtaca ctactttcca tggcagttgg aatggcagat tttagtgcag taaatggagt
    22981 tggttggctt aacttaaatg tacctttaaa atttggaatg cctagatttg aaccatctgc
    23041 aatactatca ttgtgtttga ttatgttggt acttatgacg gaatcagttg gtaatatgat
    23101 agctattcat gaaatggtag acaaagaagt aacaggtaaa aatattaaaa gaggtctatt
    23161 tggagatgga atatctacag cattatctgg aatattcaat tcatttccaa taactccatt
    23221 tggtcaaaat acaggaatag taggtcttac aggtataaaa tcaagattta tagcagttta
    23281 cgcaggggtt atattgctag tacttggatt cttaccaaaa tttgcagcaa taataggagc
    23341 aatacctaag cctgttcttg gaggcgtagg atttgcaatg tttggaatgg taatggttgg
    23401 aggagtaaaa actttaagca aagtgaaatt tgatggaact aaaaatgggg ttatagtagc
    23461 agttagtgtt ggtttgtcta tgataccact aacaaatcct gatttctatc ataatttccc
    23521 aacttgggta caaacaatat tccatagtgg aataacaaca ggtagtttat cagcagtgct
    23581 tttaaacata ttcttcaatg aactaggttc taaaaaagaa aaaaataata aagttgaaga
    23641 agcaaaataa aaataaaaca agtaaaaatc tatattgact taaagtcatt aagtattaat
    23701 aaaaataatt cagagatatt aataattcaa caaaactatc ttatatttta aataatataa
    23761 aaaagtaaat aaataacaaa tacaaataaa agaatacaat ctaaatatta aaaatattta
    23821 atttaaggga gagataataa tatggctaat ttaaaagtta atttatatgg aatggaattt
    23881 ttaaatccaa ttatgacagc ggcaggacct ggagcaaaag atggtgctct ctgtcaagag
    23941 gcagcaaaag gtggagcagg agctatatgt acaaaaacta tatctgtatt accagctgat
    24001 gtaccaagac catgtatggc aaaaactaat agtggttttt taaacacaga attatggtca
    24061 gagcttccaa aagagcaatg gatagaggaa gaatacaaaa aggtaaaaga aacagggctt
    24121 ccagtaatag taagtatggg atattcagca gagcaaatag ctgaggttgc tcctttagta
    24181 aagccttatg cagatgcagt tgaattatct actcattatg taggtacaga cgttgcacca
    24241 atagtaaatg ctttaaaagc tgcaaaagct gttttagatg taccagtatt tatgaaaatg
    24301 agtcctcata ctgacattca aactattgca aaagctgttg aagaagcagg tgcagatgga
    24361 cttgtaatga taaactcatt tggaccatgt atggcaatag atgtaaatac aggataccct
    24421 ataatgggaa gtaaagctgg atacggatgg ttatcaggtg caccaataag acctctagca
    24481 ataagatgta tatatgaagc ttctcaagtt gtaaatatac caataatcgg tgttggtgga
    24541 atcacttgtg gaaaagacgt ggctgaaatg atgatggctg gagcaagtgc tgttcaagta
    24601 tgtacagaag caatccttaa agggccttct atctatggaa aaattgctaa agaattaaat
    24661 gaatttttag atgagaatgg atatgctgat gttaatgaaa taaaaggact aactcataag
    24721 aaaatggcag ctagagggtt tagaactcat tcagtagctc cagtagtgga tgataacaag
    24781 tgtatcaaat gtaagcaatg tgtaacaagc tgtgtatacg aagctttaga agttacagat
    24841 aagttgaaca tagatgcaga caagtgtttt ggatgtggat tatgtgtaac tagatgtcca
    24901 aaaggagctt taagcatctg ctacaatcaa gtagaagcta tgaatgagta ataattatat
    24961 agaattttgg taattaactt agagtaatag gtattaggat aataaaatat atcagataaa
    25021 caaacacaca ttatgcatta ataatacagt ctaaagttaa taattttatt atattgattt
    25081 aactaaatat tagtttagct gaatattaat ttaattaggt attggtttaa tcttaatata
    25141 gatttactgc gtataagtga actaactaga ttactttaag ttaatttttt catataaaat
    25201 aaattgatac attacaagta aggtggagtc tatatgggaa ttgttttaaa aggtgggaaa
    25261 gtagtaacaa gtgaaaaaac ttactgtgca gatgtaagaa tagaagatga aaaaatagtc
    25321 gatataggtc ttgatatatc aaaagaaaat gatgaaatag ttgatgttag tgattcttat
    25381 gttataccag gaggtataga tacacacaca cactttgact tagatacagg cgttactaag
    25441 acagcagata actttgagac aggaacaaaa gctgctatag taggaggaac tactactata
    25501 ttggattttg ctacacaagc taaaggatgt tctttgaaag acggattaga agaatggcat
    25561 gaaaaagcta aggataaatc ctattcagat tatggctttc atatggctat aacagattgg
    25621 aatgactcgg tttgtaatga aatggaggat atggtgaaag agggagtatc ttcatttaaa
    25681 ctgtatatgg cgtataaagg aagccttcaa gttgatgatg gtgtaatctt tgaagcattg
    25741 agaaaagcag aagagatagg agggattatt ggtttccatt gtgaaaatgg ggacataata
    25801 tgtgaacttg tggataaagc aaagtcagaa aataatttat ctccaaaata tcatcaatta
    25861 actagaccag ctataatgga ggcagaagct acatcaagac ttatgaagat agctgaagtt
    25921 gcaaactcta aagtatatgt agttcactta agctgtaaag aatccttaga ggaggtttta
    25981 aaagctaagc aaagaggtgt ggatgtaata gttgaaactt gtcctcaata ccttctatta
    26041 aatgatgaat tatatgattt agatggattt gaaagtgcta agtatgtaat gtcaccacct
    26101 ttaagaaata aagaaaataa tgaaatatta tggaatgcta ttttagataa tcaaatagac
    26161 actataggaa cagaccattg ttcttttaat tataagggac agaaggaact tgggataaac
    26221 gatttcagta agataccaaa tggttctcca ggtgtagaac ataggatgag tcttttatac
    26281 acatatggag tctgtaaaaa taaaatatct atcaacaaga tggtagaagt aacatcaact
    26341 aatgcagcaa agttgtttgg aatgtatcct aataaaggaa ctatagaaat aggcagtgat
    26401 gcagatatat tagtcttaaa tccaaacaaa aaatccaaaa tagaagcaaa aaaacaatta
    26461 caaaatgtag attatacacc ttatgaaggg tatgaagtgg attgtcaaat agaacatgtt
    26521 tatttaagag gaaaagaagt agttagagat ggagaattaa tttgtaatac tccaagtggg
    26581 agatatataa ataggcgtct aacaaagggg gctagagaat ggtagaattt atattaaatg
    26641 gagagaaagt tgttgcaaaa gaaggcaaaa aacttttaga cttccttaga gaagatatga
    26701 atataacttc agttaaaaat ggatgttcag aaggtgcttg tggaacatgt atggttataa
    26761 tagatggtaa agctactaaa gcatgtgtat ttaaaactga taaattagct gggaaaaaca
    26821 taacaactat agagggatta tcagagagag aaagagatgt ttttgcatat tcttttgcta
    26881 gtcaaggagc tgtacaatgt ggattttgta ttccaggtat ggtaattagt tcaaaagcac
    26941 ttatagacgt taataataat cctactgaag atgatataaa gaaagcttta aaaggtaata
    27001 tatgtagatg tacagggtat gtaaaaataa ttaaagctgt cgatttagcg gcaaagattt
    27061 ttagagaaaa tatagatgtg ccaaaagtaa actgtaaggg tctagtaggt gaaaatcttc
    27121 ctagagttga tgcagttggc aaagcacttg gatattctga atatgtagat gatatgagaa
    27181 ttgagggtat gatttatggt tcagcagtta gagctaagta tcctagagct ttagttaaaa
    27241 aaatagatat agaagaagca aaagcttatc caggagttgt tgcagttcta acagctaaag
    27301 atattccagg aactataaag gtagggcact taaagaagga ttgggatact ttaataccag
    27361 aaggtgaaat aactagatac ttaggagatg gaatagtttt agtagcagca gaaactagag
    27421 aagcgttaga agaggccaaa aagctagtta agatagatta tgaggaatta acaccattaa
    27481 gtactacagc agatgcactt agagaagatg ctccaaagat acatgagaca gggaatatac
    27541 ttgttaagga acatttagta agaggaaacg ctaaagaaaa gatagaaaat tcaaaatatg
    27601 ttgtaactaa aagatatact acacctgcta cagaacacgc atttttagag cctgaatgtg
    27661 cagtagctgg tccttatgaa gatgatggag taataatcta ttcgacagac caaggggtgt
    27721 ttgccactca acatgaatgt gcagatatgt tagggttacc atatgagaag gtaagagtta
    27781 taaacaaaat ggtaggagga gggtttggtg gaaaagaaga catgagtgtt caacaccatg
    27841 cagccttact tgcataccat acaaagagat ttgtaaaagt acagttaaca agaaaagaaa
    27901 gtattattgt tcatccaaaa cgacatgcca cagaaatgga atttacgaca gcatgtgatg
    27961 aaaatggata cttaacgggt atgaaggcaa cgataatatc tgacacaggt gcatatgcct
    28021 ctcttggagg accagtgcta caaagactgt gtactcatgc agcaggacca tacaattatc
    28081 aagatattga tataacagga acagcagtat atactaataa ccctcctgga ggagcattta
    28141 gaggatttgg agttacacag agttgttttg caactgaatg taatctaaat ttacttgctg
    28201 aaatggttgg aatatctcct tgggagataa gatataaaaa tgcaataaga cctgggcaag
    28261 ttttaccaaa tggtcaattt gcagatgaag gaacagcaat ggcagagaca ctagaagctg
    28321 taaaagaaga gtatgaaaag catccacgtg caggtatagc ttgtgctatg aaaaatagtg
    28381 gggttggagt tggtatacct gatgttggaa gatgtagatt ggtgataaaa gatggcaaag
    28441 ttcacataag aacaagtgct tcttgtatag gtcaagggct tggtactgtt atgactcaag
    28501 tagtttgtga aactgctaac ctacttcctg aaaatatagt tcatgaagtt ccagatactc
    28561 atttaacacc agactctggt aatactacgg cttcaagaca gacagtattt acgggagaag
    28621 ctactaaggt tgcatcaaat aagttaaaag aagctttaga ctctggcaaa actttacttg
    28681 atttagaggg agaagagttt tatggagaat atgaaagtat tacagataaa atgggttgtg
    28741 acaaagaaaa tccagtaagt catgttgctt atggatatgc aacacaagtt gtaattctgg
    28801 atgaaaatgg aaaactagaa aaagtagtag cagcacatga tgttggaaga gctataaatc
    28861 caatcagttt agaaggtcaa atagaaggtg gagtagttat gggtcttgga tatgctctaa
    28921 ccgaagatta cccagtagtt aactctattc ctacagctaa gtttggtaca ttaggtttat
    28981 ttaaatctac agatatacca gaaatacaag ctttaatagt tgaaaagaac aaagatttat
    29041 tggcttatgg ggcaaaaggt gtaggagaaa tttgtacagt tcctactgca ccagcagtac
    29101 aaaatgccta ttatgtattt gataaagaat ttagaactga gttaccacta caaaatactc
    29161 catatagtaa aaaaaagtaa caaaaaaaag aaatattaaa taaaaaaata gatgaaattg
    29221 taaataaaaa aaaccctttt gcataaggta tattttaaat gatagaatat acatatacag
    29281 gagggttttt cttttataaa ataagtttaa taaaattgag aggtgagcag aatgaatttt
    29341 aataatagtc tagaattaac tcagtctcag aagctaataa tgactacaca acttaagcaa
    29401 tcattatcaa tattaaatat gagtaagtta gagttagaag aagagataaa aagagaagca
    29461 gagaataacc cattagttga agtcgagaaa agtggggaga taaattggga agagtatata
    29521 aaagacatgg ataggtcaag acgtttagat agaacagaga taagctataa tcctgataat
    29581 gaagttaatc tagaaaattt agttaaatat tcgtcaaatt tatatgaaga tttaaaattt
    29641 cagataagcc tgtataaact tacagacaaa gaattggaag tctgtgagta tataattgat
    29701 agtttagatg aggatggata tttaagaact gaggaaaaag taattgttga taccttaaag
    29761 atagatgaag aactttttga aaaatgttta attagtgttc agcagttgga acctagtgga
    29821 gtaggggcaa gaagtctttc agaatgtctg atgatacaaa tggctagttt aggaatatat
    29881 aatgaaattt tagaggaaat cgttacaaaa gacttaaatt taattgcaaa taataaatac
    29941 aaagagataa gtaaaaagta caatatgtca ttacaaaaat gtgttgaact aataaatata
    30001 attaagacat tagaccccaa accaggaaga acttgttcag tagagaaaag tgtatacatt
    30061 caacctgatg taacagtaga aaaaattgat gatgaattta ttgtatattt aaatgagaaa
    30121 gattcttatc aaataagaat caatagttat tataaagaca tattaaaaaa ttcacagtct
    30181 gatgaaagtg caaaagaatt tataaaagaa agactaaatt cagcaacagg acttatgaaa
    30241 aatatagaga gtaggaaaac tacagtactt aagattgcag aagagatagt aaaagctcaa
    30301 gatgaatttt tgagaaaagg gacaaaatat ataaaacctt tgaaaatgaa agacatagca
    30361 gaaaaattag aatttcatga atctactata agtagaggtg taaatggtaa atatatgcta
    30421 acaccttttg gcgtatatga atttaggtac tttttcagta gcgccattga gactgagaat
    30481 aatgaaatgg catctagtac aagcataaaa aaaattataa aggaaacaat aaaagacgaa
    30541 aataaaaaga aacctttaag tgatgaccat atatctaagt tattaaaaga aaaaggaatc
    30601 aatgttgcaa gaaggacagt tgccaaatat cgtgaagaat taggaatccc atcttcaagt
    30661 aagagaaaag aatactaata agtaaaagac aaatatcagt atggtaaggg gaaaaggcta
    30721 attaagagat gaatgtagat tgggctaaaa attttataaa gtaaaataat ataatatgaa
    30781 aaagtattaa aatgctataa ggtattaaaa aactggggaa cattaaaaca ttaagatagc
    30841 aaagagcata aaaaactaaa gaagattaaa acattaaaga acattagagc tttgaggaat
    30901 attagaactt taaagaatat taaaatttat aaaatataaa aatactaaaa agaattgaaa
    30961 aactggggaa cattaaaata ttgtaaaatg ctaaaaaact agaaaacata attaaataag
    31021 tgcttataaa gaatgattaa attaaataag tgtttgtaaa gaataattag atattagaaa
    31081 aagaagaata cctagataaa taaactatta tta
//
LOCUS       DAEHWM010000041        30764 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.042, whole genome shotgun sequence.
ACCESSION   DAEHWM010000041 DAEHWM010000000
VERSION     DAEHWM010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 30764)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30764)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30764
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.042"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..279)
                     /locus_tag="KNP36_001941"
     CDS             complement(<1..279)
                     /locus_tag="KNP36_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pilus assembly protein PilM"
                     /protein_id="HBF0873814.1"
                     /translation="MAIIKKILNLEINDDYIRLVFLRKSHKKVFIDKSIIKEINFDIK
                     NDSNSIEKIKYIEDVVRFVKEEIGKSKILYKNLYFNIQIQDIVIRNVEV"
     gene            complement(332..691)
                     /locus_tag="KNP36_001942"
     CDS             complement(332..691)
                     /locus_tag="KNP36_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HBF0873815.1"
                     /translation="MINLINKKRKGFTLVEMIVVVTILGVISSIALVKYSKVQESAKL
                     NADYTNAANIVTAASMAINDDEKTIDSLSVETLKEKGYLNTVPVPQSTSGKFELVIND
                     SGTDISVNINSKQFYPK"
     gene            complement(745..1830)
                     /locus_tag="KNP36_001943"
     CDS             complement(745..1830)
                     /locus_tag="KNP36_001943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HBF0873816.1"
                     /translation="MRLSKNIFYNLEKFYLVLNRISDKEIRVICKEIGILLESGCEIT
                     KIFEIIESQSSKKVKNLLSIVSNHIQKGNSIAESFQITGIFSKFFISMIKAGETSGNL
                     DIIMSDLSNYYDKEYKLKMKIITISIYPIILIILSILSMLFIFVFVIPNFQVVFTNNG
                     IEPPLITRVLMGISTVVTNNLAYIIFSFILFSIGSIYFFITNDNIKKLINSLKFKIPF
                     IKKINQLVATTRFSRALSVLISSGIQIVEAIDMSASVIDNEFIYERLKISNNYIKKGN
                     SIGKSLNLANIFPKLFISMANTGEESGKLDKSLNVINKFYENELNNKIEQIMKFIEPM
                     LIVFMGLIIGTFILAMVVPMFDAITNF"
     gene            complement(2001..3380)
                     /locus_tag="KNP36_001944"
     CDS             complement(2001..3380)
                     /locus_tag="KNP36_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HBF0873817.1"
                     /translation="MIKIILEESSLPMLIPEKLAKKYNVFPVEFQDDNLVVEIEDEDI
                     YALQDLRLATGKEIILKKEKKELISEKIEKYYNSFELDEDYAKKLFENLLEKAIKENA
                     SDIHIEPFKEHLIVRMRVDGELKEVSKFLVDVYPSLSTVIKLKASMDITEKRLPQDGR
                     VDIKLGGNLIDIRVSSIPTVYGEKIVLRILNRDTFLKDKLELGFSEEAIKSINRIINK
                     RAGILLVTGPTGSGKTTTVYSLLNDLKGINKNIMTIENPVEYKMDGISQIQVNSKVGL
                     SFDVGLRAILRQDPDIIMVGEIRDAETAKIAVRAAITGHLVISTLHTNDAVSSIARLL
                     EMQIPPYLLNASLIGVISQKLVRKVCNHCSHEIMIKDNFSGDVNTKVAVGCEKCNDKG
                     YFGRTAIYEILEINDDIKTCIRNMEDSSTIKDVAQNNGMITFEDSCKRLINEKITTLE
                     ECLVVNEMI"
     gene            complement(3373..4053)
                     /locus_tag="KNP36_001945"
     CDS             complement(3373..4053)
                     /locus_tag="KNP36_001945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF881 domain-containing protein"
                     /protein_id="HBF0873818.1"
                     /translation="MKKQYVFIILASTILGILVGTIFRDYSNEETVYTSKDKSIRKEI
                     KMTRKSIKELTKEKDKLDKEINSMKQNQKNSEEISEIETLRDSLSYSDVKGSGIILSI
                     DAIDEKTGNIANSIDYNKILVKVINELKVNGGKYIEINGQRINQYSEVVLAGSHININ
                     GVPVAQPYEIKCIGDKEKLSNYVDKGSKYLDSIQTNYPMKISIKTEENISMKKMNIPN
                     KLKYIKGD"
     gene            complement(4444..5523)
                     /locus_tag="KNP36_001946"
     CDS             complement(4444..5523)
                     /locus_tag="KNP36_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0873819.1"
                     /translation="MEGKVKKAFPGGNTSQGSYSFFDYIIPENVKRVFCLKGGPGVGK
                     SSLMKKIYKEFLHRGYDIDLYHCPSDPSSLDGLVIKKLGVVLMDATAPHTMDPKLPGA
                     LDEIINLGDYWNTEELEKNKQEISVYDKDISNSFKRAFKFLKSAEPIFRDIEEKYSDC
                     MDYGKVNLVTEEFIKRLFDGVKSTGNLKREKHLFGSAITPVGCLDYTENILKDVKKVY
                     YLDGEIGTGKTTLLNKVYKKAIEKGLNVEVYHYPLIPEKIETVLLTDLDIGITISTTF
                     KEEDTIDLNQFLNREKLLKYEEDIKFDEKVLDDLICWAVLNLKRAKSKHDIIESYYSP
                     NMRFDEVGKLRDKLIKRILKYEENL"
     regulatory      5811..5926
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            6101..7471
                     /locus_tag="KNP36_001947"
     CDS             6101..7471
                     /locus_tag="KNP36_001947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0873820.1"
                     /translation="MKQKWIVLIIICIGVFMSTLDGSILNIANPTIAADFKINMSQIQ
                     WVVTAYMLVVTATMLFFGKLGDKVGSNRLYTLGFFIFTIGSFLCSMSNNLSTLISSRI
                     FQAVGASILMATGLGIVSNAFPANEKGKAIGITGAVVGIGNMSGSVIGGIILEHFGWP
                     SIFIINIPIGIIAVFLGIKFLPKPVLDEQNKSFDIPGLLLFASCTTLILLAMNEKGNT
                     RLYLGITALIIFLLLALREVKFEQSFIDLPLFKNRNFTVGNIIGVACYFPQMAVSFLL
                     PFYLEQLKNLSPMMAGYVMTVHPLIMVLIAPIAGSLSDKHGAKNILTASFSFMTISLV
                     GMALLKADSPLYLLIVCLVIFGLGLGAFSSPNNSSILADVPPQKQGYGGSFLATIRNL
                     SFALGTAFFSSFFAQSLTYNQKFKSHTSAYVIASNQSYWIAASVCFIGLILTVFFMRK
                     TDKSIS"
     gene            complement(7736..8347)
                     /locus_tag="KNP36_001948"
     CDS             complement(7736..8347)
                     /locus_tag="KNP36_001948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HBF0873821.1"
                     /translation="MKIRSSEITMSAVNKSQYPAEGIPEIALAGRSNVGKSSIINTLL
                     NRRNFARTSQTPGKTRTINFYLINNEFYFVDLPGYGYAKIAKSEKEKWGGIMERYLES
                     RQELCSIFLLVDIRHEPTADDKLMYEWIKHFGYNCVVIATKADKISRGQYQKHISIIR
                     KKLQMESSEKVIPVSSLKKTGVEELWEEIVNQYNQHGYEITVD"
     gene            complement(8337..10700)
                     /gene="lon"
                     /locus_tag="KNP36_001949"
     CDS             complement(8337..10700)
                     /gene="lon"
                     /locus_tag="KNP36_001949"
                     /EC_number="3.4.21.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase La"
                     /protein_id="HBF0873822.1"
                     /translation="MEQNYTKIDHELPLIPLRGLAIFPYMILNFDIGREISLKALDQA
                     MMDEELIFLTSQKEAEVDEPGEEDFYHVGTICKVKQMIKLPGDTVRVLVEGVSRGRVK
                     KIEQEDGYFRAVIEEIVFDSDNLDSETEVEIEAFVRNVFDAFEEYINIGNRVSPEILI
                     SLADIEDVDRFIDTIAANIYLKSSQKQEILEEFDIRKRLELIYSILLEEIDILKIEKK
                     ITLRVKKQMNKVQKEYYLREQLKAIQKELGEEEDINSEADEYREKLKKIKAPKTTKEK
                     IEKEIDKFSKISSMSPDVSVSRNYLDTIFSLPWNKETKDKLDITKAKDILDEDHYGLE
                     KVKERILEYLAIRTLAKSLKGPIICLVGPPGTGKTSIVKSIARALNRKFVRISLGGVR
                     DEAEIRGHRRTYVGSIPGRIINGVKEAQTKNPVFLFDEIDKMAADYKGDPASAMLEVL
                     DPEQNKDFVDHYLEIPFDLSKILFVTTANSLSNIPRPLLDRMEVIEVSGYIEEEKLNI
                     AKKYLLPKQIKEHALKENFIKIDDETLRSIINHYTREAGVRTLERTIGKICRKVAKKY
                     VEDPTLEEVVINKSDLETYLGKDMFKYQLAEVNPQIGLVNGLAWTEVGGVTLEVEVNV
                     LKGKGEIVLTGKLGDVMKESAKTGISYIRSIVDKFDIDPEFYKTNDIHIHIPEGAVPK
                     DGPSAGITMALAVISALTKRPVPGNIAMTGEITLRGRVLAVGGVKEKLLAAHRAGITK
                     VLIPKECEADLDEIPENVKEKMEFVLVEHMDEVLEQALLKSGENNEN"
     gene            10880..11392
                     /locus_tag="KNP36_001950"
     CDS             10880..11392
                     /locus_tag="KNP36_001950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBF0873823.1"
                     /translation="MLKLFLTFLKIGAFTFGGGYAMVPLIQDELVNKQKLLEQEEFID
                     YLSIAQSYPGVLAVNISVLLGYKLYGIPGVLICTLGSALPSFCIVLVLSYLYFKNSSS
                     KILDGFFKGVAPVVIALILYSFTSMFKKLPKSKTNILLLIIAVLSVGVFNISPIYLII
                     GGGVYSLCQK"
     gene            11380..11907
                     /locus_tag="KNP36_001951"
     CDS             11380..11907
                     /locus_tag="KNP36_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBF0873824.1"
                     /translation="MSEIILLFLIFLKIGAFSFGGGYAMLPFIQQEFISKYHFITNQE
                     FLDLLAISQSTPGPVAINSATFVGFKTAGFFGSLAATIGVTIFALIGLTIISKLFSKF
                     KNNKKVENLLTVLRPITLGFILSAAFSSAKEVNWDLYGIIAFIASFYLLYKGKIGSIA
                     IVFVFGILGILLTFL"
     gene            complement(11978..13228)
                     /gene="clpX"
                     /locus_tag="KNP36_001952"
     CDS             complement(11978..13228)
                     /gene="clpX"
                     /locus_tag="KNP36_001952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HBF0873825.1"
                     /translation="MSKYEEKRQLKCSFCGKNQDQVRRLIAGPNVYICDECVELCDEI
                     IQEEIEDTIDEDTTSLPKPKEMMEILNDYVIGQEKAKKALSVAVYNHYKRIYSKKSSS
                     KDIEIQKSNILLLGPTGSGKTLLAQTLARTLNVPFAMADATSLTEAGYVGEDVENILL
                     KLIQAADFDIEKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVAN
                     VPPQGGRKHPHQEFLKIDTTNVLFILGGAFDGLEKIIQKRGGDKTLGFGAKIESKKEL
                     DLGKLYEKVLPEDLLKYGIIPEFIGRIPVLATLELLDEDALMQILQEPKNALVKQYKK
                     LLELDDVELEFEEGALRAIAKKAIERNTGARGLRSIVESVMMETMFEVPSRDNIKKVI
                     VTEKSVNEDSVNPIIVLKDQEESA"
     gene            complement(13247..13831)
                     /gene="clpP"
                     /locus_tag="KNP36_001953"
     CDS             complement(13247..13831)
                     /gene="clpP"
                     /locus_tag="KNP36_001953"
                     /EC_number="3.4.21.92"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp endopeptidase proteolytic
                     subunit ClpP"
                     /protein_id="HBF0873826.1"
                     /translation="MALVPVVVEQTGRGERSYDIFSRLLKDRIIFLGDQVNDATAGLI
                     VAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDTMQYIKPDVSTICIGMAASMGAF
                     LLAAGAKGKRLALPNSEIMIHQPLGGAQGQATDIEIHAKRILKIKETLNEILSERTGQ
                     PLEKIKMDTERDNFMSALEAKEYGLIDEVFTKRP"
     gene            complement(13981..15267)
                     /locus_tag="KNP36_001954"
     CDS             complement(13981..15267)
                     /locus_tag="KNP36_001954"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HBF0873827.1"
                     /translation="MKAELIKKEGNKVTLKITVDNNKFEAAVNKAYNKSRNKYNIPGF
                     RKGKAPRIVIETQYGKGIFYNDAIEILFPEVYPEAIKELDIDPIDNPDLDIEEISKDN
                     GLVMVLNVEVKPEFELGNYKGIEIAKVENTVSDENVDAKLQEMVEKNARLVSVEDKAL
                     EDGDTAIIDFEGFENGVAFDGGKGENYNLVIGSNTFIPGFEEQLVGKKAGEEVEVNVT
                     FPEEYHSQDLAGKPVVFNVKINDVKVKELSALDDEFAKDTSEFDSLDELKADVRAKLE
                     EEAKNRADAETRNSVVEKVAENTEIEIPEVMIQHQIDNMLNELNYQLQYQGFGLQQLL
                     EMTGRTMEELREERKEDAKKLVKSSLVLEAITKAEGIEATEEEFKAELEKMASAYNME
                     VEKIEASLRDADKEDIKGQIKIRKTIDLLVDNATIA"
     gene            complement(15461..15931)
                     /locus_tag="KNP36_001955"
     CDS             complement(15461..15931)
                     /locus_tag="KNP36_001955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0873828.1"
                     /translation="MKIGIVSDTHMMIKNMEKTIPYLKECDLIIHAGDNFTDSRYIHS
                     MTNVGIIAVKGNCDFDAVEEEVVFEVANKTIFLCHGDKYGVKYGTNMLEKKATEVDAD
                     IVIFGHTHTPFREIKDGVLYINPGSTSLPRGVSYKSFVIMDIEEDDIKIEEIRI"
     gene            complement(15931..17280)
                     /gene="rph"
                     /locus_tag="KNP36_001956"
     CDS             complement(15931..17280)
                     /gene="rph"
                     /locus_tag="KNP36_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease PH"
                     /protein_id="HBF0873829.1"
                     /translation="MTRSYDRSNEQIRPVKITRDYTKYAEGSVLIEMGETKVICTASV
                     EEKVPPFLRNSGTGWINAEYSMLPRATQQRKIRDASRGKIDGRTQEIQRLIGRTIRSV
                     VDLNKLGERTIWVDCDVIQADGGTRTASITGAFVAVAEAIYKLYKAKTIKEMPITNFV
                     SAISVGIVNGIHMLDLCYEEDSKAQVDMNIIMTDKCEFVEVQGTGEEKPFSRADLNLL
                     LELGEKGNKELIRLQREALGEISDEILGMDYGNEVVIATNNAHKLEEIGEILKDFEYK
                     VYSLKDVDLAGIEIVEDGKTFEHNALIKARTIAKKTKLIAISDDSGLEVDALGKKPGV
                     YSARYAGEHATDEENRKKLLKAMQNVPMSKRNARFVSAIAVVFPDGKEFVVRGICEGM
                     IGFEEKGKNGFGYDSLFIVKGYDKTFGEIPSVIKNSISHRANALKLMKQEFIKRVVK"
     gene            complement(17440..19464)
                     /gene="ligA"
                     /locus_tag="KNP36_001957"
     CDS             complement(17440..19464)
                     /gene="ligA"
                     /locus_tag="KNP36_001957"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HBF0873830.1"
                     /translation="MSVKDEINKLIETINYHNERYYNQDSPEISDYEYDKLMKELISL
                     EEEHPELKRIDSPTNRVGGKPLDKFNQIVHKTPMLSLSNAFSEQDLRDFDKRVQEYVG
                     ENVEYVVEFKIDGLSVGLTYNNGEFEKGATRGDGVVGEDISQNLMTVKSIPLKINDKK
                     ELIVRGEVYISKDNFRKVNEQQEEQEQPLFANPRNLAAGSLRQLDPKLTAKRPLDIFV
                     FNMENIEEYDLESHSESLEYLEKLGFSVSQSYKVCKSIDEVIEHIEYWTDNRGNLDYE
                     IDGMVIKVNNIKQRDEMGYTAKSPRWAIAYKFPAEKKKTKIVDIIVEVGRTGTITPSA
                     ILEPVRLAGTTVSRATLHNEDYIREKDIKINDTVLVQKAGDIIPQVLEVIKEERTGDE
                     IDFKMPEKCPVCSEPTIRLEGEAAVKCINMSCPAQIRRGIIHFVSRDAMNIDGLGESI
                     ITLLLNEKIIQDVSDLYYIKKEDVVDLERMGEKSADNLINSIEKSKENDLWRLINGLG
                     IKFIGVKAAKILAYNFKDLDEVISATSEQLEELEEFGSIMANSVVEFFKEDKNMNVIN
                     KLKNVGVNTKSLDNTGEKVEKIFEGMKIVLTGTLPTLKRNDAKDMIEKRGGKATSSVS
                     KSTTFVLAGEEAGSKLTKANDLGIKVIDEERFLELLKLSSKDEVKAVLES"
     gene            complement(19650..20588)
                     /locus_tag="KNP36_001958"
     CDS             complement(19650..20588)
                     /locus_tag="KNP36_001958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="HBF0873831.1"
                     /translation="MKVLFTINYGKEKFDKIRELGYDVIHYSEDSIENNEDVNTADVL
                     VTYNPFERLDISKMKNLQYIQTTSVGIDQLPKEEVLKRNIKIANNRGGYSVPIGESIV
                     LYILEIYKNSAKFFKQQQNKEWKMDFSVSELYGQRVGFLGTGTISSEAAKRLKAFGVE
                     IWGVNTDGSSKKYFDKCFATEDMNIVFEECDIVVVAMPSTKSTDGIVNKDMFKLMKDG
                     SVFINVGRGNTVNQKDLEECVEKFRGVALDVFESEPLNKDNKLWECENVIVTPHNSWV
                     SDKNKERTFNMVYNNLKHYIMENKPVDNVVDISRGY"
     gene            complement(20690..21112)
                     /locus_tag="KNP36_001959"
     CDS             complement(20690..21112)
                     /locus_tag="KNP36_001959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3783 domain-containing protein"
                     /protein_id="HBF0873832.1"
                     /translation="MSFEKINNNNLDKIHNRKCIMLVNFNKKELSLIKNVSNFAGIRD
                     HIILSDKNGENIIRDILDGNISNECENGIKSKSVIFNNTPSTQVNAFLEGLKKVRINR
                     PFTAMVTETSIDWTLNNLIENLVQERNAMSLGKTIEHK"
     gene            21300..22583
                     /locus_tag="KNP36_001960"
     CDS             21300..22583
                     /locus_tag="KNP36_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugated bile salt MFS transporter"
                     /protein_id="HBF0873833.1"
                     /translation="MNTLLNNKFSIKNFSNAWVIVLGCMLIQAVPFSIVASIQPQFIS
                     YVVEGEGFSLASFSLIFTIGTIASAIASPFIGVLFSKVNIKILYLLGCIISSIAFATF
                     SICTELWQFYTVSCIVQIGATIISAIGIPVLISAWFDEESKGKALGFAFAGGSIGSIF
                     LQPLAVRLLATQGYSRSYLIFGIIALIVGIPVILFILRMPKDINEKVKSKGKKEKASD
                     TISPSVWGYTLKEAKKIKYFWIMTIGFIFVGIYVSSLSVQYPTYLRNYLNPILIGTVG
                     STFALFALIGNLFGGLLFDKFGQTKPLIISFVLVLIATLSLLLVDKSSTFAFVFAILK
                     GLSVFAYMIGPAYLTGSFFGQKEFGSIYGIVQLIFAVGFALGSTLFGLLVDNFGYRFS
                     WSIIILSVIIAYTLLIITSIGMKKLNKERLDKLMQ"
     gene            complement(22661..23176)
                     /locus_tag="KNP36_001961"
     CDS             complement(22661..23176)
                     /locus_tag="KNP36_001961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBF0873834.1"
                     /translation="MNYFVIADPDKCIGCRTCMIGCVVAHSDEDIFYQNPDEINFNPK
                     LSVIKTKEVSAPIQCRHCEDAPCAKACPNGGIVRVGNTIKINEENCIGCKTCMLACPI
                     GAIDIVTLKDVDEGKLCFRERMTANKCDFCIESPEGPACVNVCPTKAFTIVKDEDIDS
                     KVKNKRKLAIL"
     gene            complement(23176..24552)
                     /locus_tag="KNP36_001962"
     CDS             complement(23176..24552)
                     /locus_tag="KNP36_001962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase small subunit"
                     /protein_id="HBF0873835.1"
                     /translation="MIINIDKDLCTGCRECSKVCPVNAIEGEEGKPQEINLDRCVMCG
                     QCVQTCKSYASVIDEGFEFLQEKKQEREIPESINEPIFAAYNVCDIDKVKKALSDPNV
                     FTMVQCAPAVRVALGEDFGYYLGYLGAGKMAAALRALNFDRVYDTNFAADLTIMEEGS
                     ELIKRVTEGGTLPMFTSCCPAWVKFMEKNYPKLTNHLSSCKSPQQMGGAIFKTYGAEI
                     NNVDASKIFSVSIMPCTCKKYECDREEMDSSGYRDVDVVLTTRELAYLIKDMGIDFKN
                     LREEKFDSPLGSYSGAGTIFSVTGGVMEAAIRTGYELITGESIPDVEVKQVRGENGFR
                     KSTIKIGDLDLRVGVVSGLKNVIPVLEDLEKGKLDVDFIEVMTCPVGCVSGGGQPKIL
                     LEEYKELAYENRTKATYVHDEHLAIRKSHENPDIKKLYDEYLVEPLGEKSHHLLHTTY
                     CIGKEVAK"
     gene            complement(24577..25128)
                     /locus_tag="KNP36_001963"
     CDS             complement(24577..25128)
                     /locus_tag="KNP36_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBF0873836.1"
                     /translation="MKNKIGSFVIADPNKCTGCRACEVACFTMHNQHNNVGYTVGTVD
                     IPVIPRLYLVKGDNFCMPIQCRHCEDAPCLNSCPQKAIVKENNIMSVNEEKCIGCKTC
                     LLACPFGAIDLLPQYEDGKEVEQVILDENKKIAYKCDLCKDNEKIACISACPQEALKL
                     VTPIDDKKAKNRQAALSLLLTNK"
     gene            complement(25186..25401)
                     /locus_tag="KNP36_001964"
     CDS             complement(25186..25401)
                     /locus_tag="KNP36_001964"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873837.1"
                     /translation="MQIHRELSKSENEYMCTKKEEQRYSKCEICGVLIDDTDKVYNNT
                     YNLCKKCKRNISTEKIVKYINIYDESK"
     gene            complement(25370..26203)
                     /gene="fdhD"
                     /locus_tag="KNP36_001965"
     CDS             complement(25370..26203)
                     /gene="fdhD"
                     /locus_tag="KNP36_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate dehydrogenase accessory
                     sulfurtransferase FdhD"
                     /protein_id="HBF0873838.1"
                     /translation="MNNIYSKTKLQENSKDKVFENSYSLVDYKYLNSFNVEVSKINEH
                     EVSIDNEEIIAEYPLSFILNDKYVNTFLCTPYNLEELIVGFLKTKGYIENKKSLLKFE
                     INESERFAKVTIQEKQKNQDEQIIFLNSLDYITCAPVKSNIKINYDTIYSIMDKNLNS
                     SELFKNTGGVHSVSVFNFDKKIVTCEDVARHNAMDKAIGFCVLNDITLKDKIVAVSGR
                     ISLEMILKAAMTQIPIVVSKSAPTNLSIELSKKLNITLIGFVRGRRMNIYANPQRVIK
                     K"
     gene            complement(26252..28396)
                     /locus_tag="KNP36_001966"
     CDS             complement(26252..28396)
                     /locus_tag="KNP36_001966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:complement(27980..27982),aa:Sec)
                     /transl_table=11
                     /product="formate dehydrogenase H subunit alpha,
                     selenocysteine-containing"
                     /protein_id="HBF0873839.1"
                     /translation="MEKKILTVCPYCGAGCQLYLVVKDNKILRAEPANGRTNQESLCL
                     KGRYGWDFLNDPKILTPRLKKPMIRKQGVLEEVEWDEAINYTASRLNEIKEKYGPDSI
                     MGTGSARGPGNEANYIMQKFMRATIGTNNVDHCARVUHAPSVAGLAYSLGSGAMSNSI
                     PEIENADVLFIFGYNGADSHPIVANRIVKAKKNGAKLIVTDPRVTESARIADIHLPIK
                     GGTNMVLVNAFGNVLIEEGLYNKEFVQNHTQGFDEYKEIVKPYTAKYAEKITGIPEEL
                     IRKAMREYAKGKKAMILYGMGVCQFGQAVDVVKGLASIALLTGNFGRESVGIGPVRGQ
                     NNVQGACDMGALPNVYPGYQNVTDDKIREKFEKAWGVKLSPNNGYSLTQVPNLVLKEK
                     KLKAYYIFGEDPVQSDPDASEVREALDELEFVIVQDIFMNKTALHADVILPATSWGEH
                     EGVYTCADRGFQLMRKAIEPQGDVKPDWQIISEISTAMGYPMNYKNTKEIWDELRQLC
                     PSFLGATYEKIETQGCVQWPCKSESMEDKGTMYLYEGQKFSTPNGKGNLFAAEWRPPM
                     EVEDDEYPFSLCTVREVGHYSVRTMTGNCRTLSSLEDEPGRVQINSNDAEKLGIEDDE
                     LVRISSRRGSVITRATVTDRVKEGATYMTYQWWVGACNELTIANLDPISKTPEYKYCA
                     VKLEKLEDQELAEKCVREEYQSLKDKMTATNI"
     gene            complement(28647..29705)
                     /locus_tag="KNP36_001967"
     CDS             complement(28647..29705)
                     /locus_tag="KNP36_001967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBF0873840.1"
                     /translation="MDRLKNIRKSLLQYTFLFLLIGITIYLVFKTLDIKMLSNVMVMV
                     DKKFLFIGALAIMCHIMLEGVVMKIIIESTHKVNIRFIGFKLAIMGFYYNLITPFASG
                     SQPVQIYVLKKCKMPLSKASAVVTNKSIIFQIVVTFYCTILVLMNFAMLEKQMKMIMP
                     LVFLGIAINSFVLIMIILVILNPEKIKYFMRITIKHLSKIKFLKFLDNKIESIESFID
                     DYSKAINFFAKNKKVLISTIIVTFIQLSAYFSVSFWIYKAFNLQGYSYIYILTLQAFL
                     YMAISPIPTPGNVGANELAFFTIFKSVFPQPLMGYAVFLYGGFMYYLILIGSGIFTVI
                     THYRMKNRIGRNIVLSEN"
     gene            complement(29916..30575)
                     /gene="cprR"
                     /locus_tag="KNP36_001968"
     CDS             complement(29916..30575)
                     /gene="cprR"
                     /locus_tag="KNP36_001968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CprR"
                     /protein_id="HBF0873841.1"
                     /translation="MSKILVVDDELDMLKLIENVLKRDGHEVKVISDVEKAMNMDFNY
                     FNLIILDVMMPKMDGFEVCKTIRNKVDCPILFLTAKNMESDIMYGLGIGADDYITKPF
                     GVGELRARITAHLRRESREKKNLLTISNVQFNFLGKEVSIDGKKINFTKSEYLICEFL
                     AKNKGQVFSKERIYESVYGFDGESDISTITEHIKNIRSKLKQYDIYTIETVWGIGYKW
                     V"
BASE COUNT         9302 a         5560 c         3310 g        12592 t
ORIGIN      
        1 aacttcaaca tttctaatga ctatatcctg aatttgaatg ttaaagtata aatttttata
       61 taatattttt gatttaccaa tctcctcttt tacaaatcta actacatctt ctatatattt
      121 aatcttctca atcgaattac tatcattttt tatatcaaag ttaatctctt ttataattga
      181 tttatctata aaaacttttt tatgactttt tcttaaaaat acaagcctta tataatcatc
      241 atttatttct aagtttagaa tttttttaat tatagccatc tccttcttaa ataaaaataa
      301 ttttaaaact tacagcaatc aatataaaat attattttgg ataaaattgc ttagaattta
      361 tatttacgct tatatctgtt ccgctatcat ttatgacaag ttcgaattta cctgatgtac
      421 tctgaggaac tggaacagta tttaggtatc ccttttcctt caatgtctct acacttagag
      481 agtctattgt cttttcatca tcattaattg ccatgctagc tgcggttact atattagcag
      541 cattcgtata gtctgcattt aatttggcac tttcttgaac cttactatac ttaactaatg
      601 ctatactaga tataacgcct aaaatagtta ctactacaat catttcaaca agtgtaaatc
      661 cttttcgttt tttatttatc aaatttatca attaaatatt ctctcctttt caaaagtttc
      721 atctaataaa atttattttt ctctctaaaa attagtaatt gcatcaaaca taggaacaac
      781 cattgctaaa ataaaagtac caataattaa tcccataaat acaattagca taggttctat
      841 aaatttcatt atttgctcta ttttgttatt taattcattt tcataaaatt tatttattac
      901 atttagactt ttatctagtt tcccactttc ttctcctgta tttgccattg aaataaataa
      961 ttttggaaaa atatttgcta aattcaaaga tttacctatg ctatttcctt tttttatata
     1021 attattagaa atctttaacc tttcataaat aaattcgttg tctataacac tagctgacat
     1081 atctatagct tccacaattt gtattccact gctaattaaa acggacaatg cccttgaaaa
     1141 tcttgttgta gctactaact gattaatttt ttttataaaa ggtattttga attttaacga
     1201 attaatcaat ttttttatat tatcatttgt tataaagaaa taaatgcttc ctattgaaaa
     1261 caatataaaa ctaaatatta tataagctaa gttatttgta accactgtag atattcccat
     1321 taaaactcta gttattaaag gtggttcaat tccattgttg gtaaaaacca cctgaaaatt
     1381 aggtattaca aatacgaata taaacaacat tgataagata gataatatta taagtattat
     1441 tggatatatt gaaatagtta ttattttcat ttttaatttg tattctttat cataataatt
     1501 agataaatca ctcattatta tatctaagtt tccactagtt tctcctgctt ttatcatact
     1561 tataaagaat ttagaaaata tacctgttat ttgaaatgat tctgctattg agttaccttt
     1621 ttgaatatga tttgatacta tactaagcaa gttctttact tttttacttg actgactctc
     1681 aatgatttca aatatttttg taatttcaca tccagattcc agcaatatgc ctatctcttt
     1741 gcaaattact ctaatttctt tatcactgat tctatttaat actaaataaa acttttctaa
     1801 attataaaat atatttttag ataatctcat gtactataat accttccaaa ttatattaat
     1861 tacaattaaa taaacttaat attttctaat ttaatgcatt taattttatt tcacttaaat
     1921 ataatttata ctcaaacatc ttaattaaaa tagattaaat aaagacaact gaccaaacga
     1981 agtttaacta tacaattcag ttaaatcatt tcatttacta ctaaacactc ttctaatgtc
     2041 gttatttttt catttattag tcttttacaa ctatcttcaa atgttatcat tccattattt
     2101 tgtgctacat ctttaatagt actagaatcc tccatatttc ttatacatgt ctttatatca
     2161 tcattaattt ctaagatttc ataaattgct gttcttccaa agtatccttt atcattacat
     2221 ttttcacacc ctacagctac cttagtattt acatctccac taaaattatc ttttatcata
     2281 atctcatggc tacaatgatt gcagactttt ctaaccaact tttgagatat aacacctata
     2341 agagaggcat ttaaaagata tggtggtatt tgcatttcta gtaatctagc tatggaagat
     2401 actgcatcat tagtatgtaa agtacttata actaaatgac ctgttatagc tgctcttact
     2461 gctatcttag ctgtttctgc atctcttatt tctccgacca ttattatatc tgggtcttgt
     2521 cttaatatcg ctctaagacc tacatcaaag ctcaacccta cttttgaatt tacttgaatc
     2581 tgacttatgc catccatctt atactctaca ggattttcta tagtcataat atttttattt
     2641 attcctttta aatcatttaa taaggaatat actgttgtag tctttccact acctgtagga
     2701 cctgtcacta ataatattcc tgctctttta tttattatac gatttataga ttttatagct
     2761 tcctctgaaa aaccaagttc taatttgtct tttaaaaaag tatctctatt aagtatcctc
     2821 aaaactattt tttcaccata gacagttggt attgatgaaa ctctaatgtc aattaaattt
     2881 ccacctaact ttatatccac cctaccatcc tgaggaagcc ttttttctgt tatatccatt
     2941 gatgccttta attttataac cgtagacaat gatggataga catcaactaa aaactttgat
     3001 acttccttta gttctccatc taccctcatt ctcactatta aatgttcttt aaatggttct
     3061 atatgtatat cacttgcgtt ttcttttata gctttttcta aaagattttc aaataatttt
     3121 tttgcataat cctcatcaag ttcaaagcta ttataatatt tttcaatctt ttcacttata
     3181 agttcttttt tctccttctt caatataatt tctttacctg tagctaatct caagtcctgt
     3241 agagcataaa tatcctcatc ttctatttct acaactaaat tatcatcttg aaactcaact
     3301 ggaaatacat tatatttttt tgcaagtttt tctggtatta acattggcaa actgctttcc
     3361 tctaatataa tcttaatcac cctttatata ctttaattta ttaggtatat tcattttttt
     3421 catagagata ttttcttcag tttttatgct tattttcatt ggataattgg tttgtatgct
     3481 atctaaatat ttactacctt tatctacata attagatagt ttctccttat ctccaatgca
     3541 ctttatttca tatggttgtg ctacaggaac tccatttata tttatatggc ttcctgcaag
     3601 tacaacttct gaatattgat taattctttg accatttatt tctatgtatt ttcctccgtt
     3661 tacttttaat tcatttataa cttttacaag aatcttatta tagtctatac tattagctat
     3721 attccctgtt ttttcatcta tagcatctat acttaatatt atcccactac cctttacatc
     3781 tgaatatgat agactatctc taagtgtttc tatttctgat atttcttcag aatttttttg
     3841 attttgtttc attgaattaa tttctttatc taacttgtct ttctctttgg ttaattcttt
     3901 tatagatttt cttgtcattt ttatttcttt tcttattgac ttgtctttgc ttgtataaac
     3961 tgtttcttca ttgctataat ctctaaatat ggttccaaca agtataccta aaatagtact
     4021 tgctagtatt ataaacacat attgtttttt catactgtat tgctccttac aaatttattt
     4081 ttatatgata attttcttta attaaatatt aaacatttac atatgcttat tatatcaaag
     4141 ttatatatta aaattcatct ttagtatata atatcataca ttgaactcct atcactaatt
     4201 taccaatatc aagtatgcat ttttagatgt tcttaaaatt atataaactt tcaataaaca
     4261 ttgttgtgat attataaaaa aacataaatt aggaaaggaa ataataatta tgaaaaacaa
     4321 ataatggctt tggagattat taatatcatt ttttagcaaa aaaagtaaaa tggcatagcc
     4381 tcaaagctac accaatttac taaaaattat attattacta acgttaattt taaacatatg
     4441 cgtttataag ttttcctcat attttaaaat tcttttaatt aacttatctc ttaatttccc
     4501 tacttcatca aatctcatat taggactata gtaactttct ataatatcat gtttagactt
     4561 ggctctctta agatttagta ctgcccaaca aattaaatca tctaaaactt tttcatcaaa
     4621 tttaatatct tcttcatatt taagtagttt ttctctattt aaaaactgat ttaaatcaat
     4681 tgtatcttct tctttaaaag tcgtacttat agttatgcct atatctaaat cagttaatag
     4741 tacagtttca attttctctg gaataagtgg ataatgataa acttctacat ttaaaccttt
     4801 ttcaatagct ttcttatata ctttgtttaa taatgtagtt ttcccagttc ctatttctcc
     4861 atctaaataa tagactttct ttacatcttt taaaatgttt tctgtataat ctaaacaccc
     4921 tacaggagtt atagctgaac caaataaatg cttttctctt tttagatttc ctgtgctttt
     4981 aactccatca aataaccttt ttataaattc ttctgtgacc aaatttactt ttccataatc
     5041 catacaatca gaatattttt cttctatgtc tctaaagatt ggttctgctg attttaaaaa
     5101 cttaaatgct cttttaaatg aattactaat atctttatca taaactgata tttcttgttt
     5161 attcttttct aattcttctg tattccagta atcacctaaa ttaattatct catccaaagc
     5221 tccaggtagc tttgggtcca tagtatgtgg ggcagttgca tccataagta ccacgcctaa
     5281 tttctttata actaaaccat ccaacgaact tgggtcagaa ggacaatgat ataaatcaat
     5341 atcatatcct ctatgcaaaa actctttata aatttttttc ataagtgagg attttcctac
     5401 tccaggtcca ccctttaaac aaaaaactct ttttacattt tcaggaatta tatagtcaaa
     5461 aaaagaatat gagccttgtg atgtatttcc acccgggaat gccttcttta cctttccttc
     5521 catattagcg cctcctcata atttacaata tctcttaatt aagatattca tattataaga
     5581 attttattac agctttctga ttttgataaa tttaaaactt accatctaat actaataaca
     5641 ggttaatttt atctaattat tatagattct catactgttc cttattctat ctataaatac
     5701 aatttaagtg tccatattga aatatttgta ttgtaataca gctggatatt acttaaatcc
     5761 aattgtttcc attataattt tatgttaaaa taatattaca aaatacatct gtttttcttc
     5821 ataaacgggt gaaattccct atcggcggta aaagcccgcg agccttatgg cataatttgg
     5881 tcatattcca aagccgacag taaaatctgg atggtagaag aaaatagtat atgagtacct
     5941 ttatgtaatt ttacatgagt aatctataca aatccttcaa ctaccgtatt tattcatgaa
     6001 attagacaca ttcaaggtac ctaatataca ggtgcttttt ttgttgttta ttttacaatt
     6061 atatcgtact tataaaatct attaagattg gagtgttatc atgaaacaaa aatggatagt
     6121 attgattatc atctgtattg gtgtatttat gtctactctt gatggaagta tactaaatat
     6181 cgcaaatcct acaattgctg ctgactttaa aattaacatg tcacaaattc agtgggttgt
     6241 aacagcttat atgcttgttg taacagctac tatgttattt ttcggaaaac ttggcgataa
     6301 agtaggttca aatcgtctat acacattagg attttttata tttacaatag gttcttttct
     6361 gtgtagtatg tcaaacaatt tatcaacatt aatttcttca agaatctttc aggcagttgg
     6421 agcaagtatt ttaatggcta ctgggcttgg tatagtttcc aatgcatttc cagcaaatga
     6481 aaaaggaaaa gctataggaa tcactggagc tgtagttggt ataggaaata tgagtggttc
     6541 tgtaattgga ggtataattt tagaacattt tggatggcct tctattttta ttatcaatat
     6601 acctattggt attatagcag tctttcttgg cattaaattt ctacctaaac ctgttttgga
     6661 tgaacaaaac aagagctttg atattccagg tcttctactt ttcgcatctt gcactacgct
     6721 tatattactt gcaatgaatg agaagggtaa tacaagattg tatttaggta taacagcact
     6781 tataatcttc ttattgttgg cattaagaga agtaaaattt gaacaaagct ttattgacct
     6841 acctctattt aaaaatagaa actttactgt aggcaatatc attggagtag cttgttattt
     6901 tcctcaaatg gcagtatctt ttctacttcc attttattta gaacaattaa aaaatttatc
     6961 tcctatgatg gctggttatg taatgactgt acatccactt attatggtac ttatagcacc
     7021 tattgcaggt tcactttctg ataaacacgg tgcaaaaaac attctaacag catctttttc
     7081 atttatgacc atctcactag ttggaatggc acttttaaaa gcagattctc cattgtatct
     7141 tttaattgta tgtttagtta tttttggact tgggctagga gcatttagtt caccaaacaa
     7201 tagtagtatt ttagcagatg ttcctcctca aaaacaggga tacggaggca gttttcttgc
     7261 aactattcgt aatttatcat ttgctcttgg aacagcattt tttagtagtt tttttgcaca
     7321 aagtcttaca tacaatcaaa agtttaaaag tcacacatca gcctatgtta tagctagcaa
     7381 tcagtcttat tggattgcag catcagtatg ttttataggg cttatactaa ctgttttctt
     7441 tatgagaaaa acagataaat ctatttctta aatgctattt attgctgact acataagtca
     7501 ataatttttt agttgaacta atttatacta attttcccat accttactaa aatttattag
     7561 tatttaacaa aattactgat atttattgtt tataaacaat aaggatgcca aaaaaagttc
     7621 attaaaacta ttttaaggca tcctatattt tgctttaata ttaatataat taaaactaac
     7681 tattattaca tttattattc aaataaatct catgtcaata tttaacattt taaatttaat
     7741 ctactgttat ttcatatcca tgttgattgt attgatttac aatctcttcc cataattctt
     7801 caacaccagt cttttttagt gaagaaacag gaattacttt ttcactactt tccatttgca
     7861 atttttttct tattatactt atgtgttttt gatattgtcc tctagatatt ttatctgcct
     7921 tagttgcaat aactacacag ttatatccaa agtgctttat ccattcatac ataagcttat
     7981 catctgctgt aggctcatgt ctaatatcta caagtaggaa tatagaacat aactcttgtc
     8041 tactttctag atatcgttcc attatacctc cccacttttc tttttcagac ttagctatct
     8101 ttgcatatcc atagcctgga aggtctacaa aataaaattc attatttatt agataaaaat
     8161 ttatagttct agtttttcct ggtgtttgac tggttctagc gaagtttctt ctgttaagca
     8221 atgtatttat tattgatgat tttccaacat ttgacctacc agccaatgct atctctggga
     8281 ttccttctgc tggatactgt gatttattca cagcactcat agttatctct gaacttctaa
     8341 ttttcattat tttcaccact ctttaataaa gcttgttcta atacttcatc catatgttct
     8401 acaagcacaa actccatttt ttcttttaca ttttctggta tttcatctaa atcagcttca
     8461 cattctttag gaattaatac ttttgttata ccagctctat gagctgctaa taacttttct
     8521 ttaactcctc ctactgctaa gactctacct cttaaagtta tctctcctgt cattgctata
     8581 tttccaggca caggtctttt agtaagtgct gagattactg caagagccat agttatacca
     8641 gctgatggtc catcttttgg aacagcacct tctggaatgt gtatatgaat atcattcgtc
     8701 ttataaaatt cagggtctat atcaaacttg tccactattg accttatata agagatacct
     8761 gtcttcgcag attccttcat aacatctcct aattttccag ttaatacaat ttctccttta
     8821 cctttaagta cgtttacttc tacttcaagt gtaactccac caacttctgt ccatgcaaga
     8881 ccatttacta atcctatttg agggttaact tctgcaagtt gatacttaaa catgtctttt
     8941 ccaagatatg tctctaggtc agacttattt ataacaacct cttcaagagt tgggtcttca
     9001 acgtattttt tggcaacctt tctacaaatc ttaccaatag ttctttctag tgttcttaca
     9061 ccagcttctc ttgtataatg gttgattata cttcttaaag tttcatcatc tatttttata
     9121 aagttttctt ttaaagcatg ttctttaatt tgttttggaa gtaggtattt ttttgctata
     9181 tttaattttt cttcttctat atatccagat acttctatta cttccattct atctaataat
     9241 ggtcttggta tattacttag actatttgct gttgtaacaa atagtatttt tgacaaatca
     9301 aaaggtattt ctaagtaatg gtccacaaaa tccttatttt gctctgggtc taatacttct
     9361 agcattgctg aagctgggtc acctttataa tctgctgcca tcttatctat ctcatcaaat
     9421 aagaatacag gattttttgt ttgggcttct tttaccccat taattattct tcctggaatt
     9481 gaacctacat aagttcttct atgacctctt atttctgctt catctctaac tccacccaaa
     9541 gatattctta caaattttct atttaatgct ctggcgattg attttactat agatgtcttt
     9601 cctgttcctg gaggaccaac tagacatatt ataggccctt taagtgactt agcaagagtt
     9661 cttatagcta gatactctag tattctctcc ttaacttttt ctaatccata atggtcttca
     9721 tctaatatat cttttgcctt agttatatct aatttatctt ttgtctcttt attccatggc
     9781 aatgagaata tagtatctaa atagtttcta cttacagata catctggaga catagaagat
     9841 atttttgaaa atttatctat ctctttttct attttctctt tagttgtctt aggtgctttt
     9901 atttttttaa gcttttctct atactcatct gcttcagagt ttatatcttc ttcttcacct
     9961 aattctttct gtatagcttt taattgttct ctaagataat attctttttg aaccttattc
    10021 atctgttttt ttactcttaa agttattttc ttttctattt ttaatatatc tatttcctct
    10081 aataatatag aataaataag ttcaagtctt tttctaatat caaattcttc taatatttct
    10141 tgtttttggc ttgattttag atatatgttt gcagctatcg tatctataaa tctatctaca
    10201 tcttctatat cagctaaaga tattaatatt tctggtgata ccctatttcc aatatttata
    10261 tactcttcaa aggcatcaaa tacatttctt acaaatgctt caatttcaac ttctgtttca
    10321 ctatccaaat tatcactatc aaatactatt tcttctatta ctgctctgaa atacccatct
    10381 tcttgttcta ttttctttac tctacccctt gatacacctt caaccaaaac acgaactgta
    10441 tctcctggta attttatcat ttgcttaact ttacagattg ttcccacatg ataaaaatcc
    10501 tcttctcctg gctcatctac ctctgcttct ttctgagaag ttaaaaatat aagttcttca
    10561 tccatcatag cttggtctaa agctttaaga gatatctctc tacctatatc aaaatttaat
    10621 atcatatatg gaaatatagc taatcctctt agaggaatta atggtaattc atgatctatt
    10681 ttagtataat tttgttccat caacattact ccttttctag tctaattgct ttgcttttaa
    10741 tattatatat ttgaacaagt taattttcaa cattaatgat aaattcttag aatactatca
    10801 tactatatta tctttttatt atgatataat attaatatta gtatacttag atgttattta
    10861 tcttttggag gtttctatta tgttgaaatt gtttttaacc tttttaaaaa ttggtgcgtt
    10921 tacatttggt ggtggatacg ctatggttcc tcttatacaa gatgaacttg taaacaaaca
    10981 aaaactttta gagcaggaag aatttattga ttatttatcc atagctcaaa gttatcctgg
    11041 agtactggca gttaatatat ctgtattatt aggatataaa ctttatggta taccaggagt
    11101 tcttatatgt accttaggct ctgctttacc atcattttgt atagtcttag tcttatcgta
    11161 tctatacttt aaaaattcat catctaaaat tttagatgga ttttttaaag gagttgcgcc
    11221 tgttgtaata gctcttatat tgtattcttt tacgagcatg ttcaagaaac taccaaagtc
    11281 taaaactaac atactactat taattatagc agttttatct gttggtgtat tcaatataag
    11341 ccctatttat ttaataattg gaggaggtgt atatagtcta tgtcagaaat aatactactc
    11401 ttcttaatat tccttaaaat aggggcattt agttttggtg gcggttatgc catgctacca
    11461 tttatccagc aagaatttat atctaaatat cactttataa ctaatcaaga gtttttggat
    11521 ttacttgcta tatcacaatc tacaccaggt cctgtagcaa taaatagtgc tacatttgta
    11581 ggatttaaga ctgctggctt ctttggttct ctagctgcaa ctattggtgt tacaattttt
    11641 gcattaatag gtctaactat tatatcaaag ttattttcta aatttaaaaa taataaaaag
    11701 gtagaaaact tattgacagt tcttagacca attactctag gattcatatt atcagcagct
    11761 ttttcatctg ccaaagaagt taattgggat ttatatggaa taattgcatt tatagcatca
    11821 ttttatcttt tatataaagg aaaaattggt tccattgcaa ttgtattcgt ctttggtatt
    11881 ctaggtatat tactcacatt tttataataa tgatacctat tttatattta gcatattaac
    11941 ataaaaaaag gagcttttaa agctcctttt catcatctta tgcactttcc tcttgatcct
    12001 taagtactat gataggattt actgagtctt cgttcacaga tttctctgtt actataacct
    12061 tctttatatt atctctagat ggtacttcaa acatagtttc catcattacg ctttcaacta
    12121 tacttctaag tcctctagct cctgtatttc tttctatggc ctttttagcg attgcacgaa
    12181 gagcaccttc ttcaaattct agctcaacat catctaactc caataacttt ttatactgtt
    12241 ttactagagc atttttaggt tcctgtaata tctgcattaa tgcatcttca tccaacaact
    12301 ctaaagtagc taaaactggt attcttccta taaactctgg tattatacca tattttaata
    12361 aatcctctgg aagtactttt tcatacagct tccctaaatc taattctttt ttactttcta
    12421 ttttagctcc aaaacctagt gttttatctc caccacgttt ttgaattatc ttctctaatc
    12481 catcaaaagc tccacctaat ataaataata cattagtagt atctatcttt aaaaattctt
    12541 gatgaggatg ttttcttcct ccttgtggtg gaacatttgc aacagtacct tctaatattt
    12601 ttagaagtgc ttgttgaaca ccttcaccac taacatctct agttatagat gggttttcag
    12661 attttcttgc aatcttatct atctcatcta tatatattat acctctttca gctttttcta
    12721 tatcaaaatc agcagcttga ataagtttta aaagtatatt ttcaacgtct tctccaacat
    12781 atccagcttc agtcaatgat gtagcatctg ccattgcaaa aggtacattt agagttcttg
    12841 ctagagtttg agcaagtaat gtctttccag aacctgtagg tcctaataaa agtatattac
    12901 tcttttgaat ttctatatcc ttactactag attttttact gtatattctc ttataatgat
    12961 tataaaccgc aactgataaa gcttttttag ctttttcttg acctattaca taatcattta
    13021 gaatctccat catttccttt ggttttggta aagatgtagt atcttcatct atagtatctt
    13081 ctatttcttc ctgaataatt tcgtcacaaa gttcaacaca ctcgtcacaa atatatacat
    13141 ttggacctgc aattaatctt cttacttgat cttgattttt accgcagaat gaacacttta
    13201 attgtcgttt ttcttcatat ttagacatat taacacctct ctctatctac ggtctctttg
    13261 taaatacttc atctattaaa ccatattctt tggcttctag tgcactcatg aagttatcac
    13321 gttcagtatc cattttaatt ttttctaatg gctgaccagt tctttcagat aatatctcat
    13381 ttaaagtttc ttttattttt aaaattctct ttgcatgaat ttctatatct gttgcttgac
    13441 cttgagctcc acctaatggt tgatgtatca ttatttcact atttggtagt gctagtcttt
    13501 ttccttttgc tcctgctgcc aacaagaatg ctcccataga agcagccata cctatacata
    13561 tagtacttac atctggtttg atgtattgca tagtatcata tatagccatt ccagaagtta
    13621 tacttcctcc tggagaattt atatataaat gtatatcttt gtctgggtct tcagcttcta
    13681 aaaataatag ctgtgctact ataagccctg ctgtggcatc gttaacttga tctcctaaga
    13741 agattattct gtcttttaat agtctagaaa aaatatcata agatctttct cctcttcctg
    13801 tttgttcaac aactacaggt actaatgcca tggtttcata ccccctttat tctatataat
    13861 ttacagtagc tttttttaag ctactgtaaa ttattatacg catttaacta aattatattt
    13921 gcacatcatt atatactaaa catttcataa cgtcaactat attagttagc gtttatttta
    13981 ttaagctatt gttgcattat caactaataa atctattgtt tttcttattt ttatttgacc
    14041 ttttatatct tctttgtcag catctcttaa agaagcttct attttttcta cttccatatt
    14101 gtaagcagaa gccatttttt ctaactcagc cttaaattct tcttctgttg cttcaattcc
    14161 ttcagcttta gttattgctt ctaatactaa agaagactta actaattttt tagcatcttc
    14221 ttttctctct tctcttaatt cttccatagt tctaccagtc atctctagta attgttgtaa
    14281 tccaaatcct tgatattgta attggtagtt aagttcattt aacatattat ctatttgatg
    14341 ttgtatcata acttctggta tttctatttc tgtattttca gcaacttttt ctactactga
    14401 atttctagtt tctgcatctg ctctattttt agcttcttct tctaacttag ctcttacatc
    14461 tgcttttaat tcatctaaag aatcaaattc actagtatct ttagcaaatt catcatcaag
    14521 tgcagataat tcttttactt ttacatcatt tatttttaca ttaaatacaa ctggttttcc
    14581 agctaaatct tgtgagtgat attcttctgg gaaagtaaca ttaacttcta cttcttcacc
    14641 agctttttta cctactaatt gttcttcaaa tcctggtata aatgtgtttg aacctataac
    14701 taagttataa ttttcacctt taccaccatc aaaagctaca ccattttcaa aaccttcgaa
    14761 gtctattata gctgtatctc catcttctaa agctttgtct tctacactta ctaatctggc
    14821 atttttttca accatttctt gtagtttagc atcaacattt tcgtcactta cagtattctc
    14881 aaccttagct atttctatac ccttgtagtt tcctaattca aactctggtt taacttctac
    14941 attaagaacc ataaccaacc cattgtcttt acttatttct tctatatcta aatctggatt
    15001 gtctattggg tctatgtcta attccttgat agcttctgga taaacttctg ggaataatat
    15061 ttctatagca tcattgtaga atataccttt tccgtattga gtctctataa caattcttgg
    15121 agctttacct tttctaaatc caggtatatt gtatttattt ctgcttttat tataagcctt
    15181 atttactgct gcttcaaatt tattgttatc tactgttatt tttaaagtaa ctttattacc
    15241 ctctttttta attagttctg ctttcatcct tctaatcctc ctagtgatat ttatgtaata
    15301 cccgataacg gtattataat tcattctatt tataattcaa ccacttaatt atatcacata
    15361 agttttttta tttacaagtg ttccattaat atcgttgtac ttatttgata aaatttaatt
    15421 ttttgagcgt tttttgccat ttttttagat aaatacacct ttatatgcgt atttcttcaa
    15481 tttttatgtc atcttcttct atatccataa tgacaaaact tttatacgat actcctcttg
    15541 gaagtgaagt gcttccagga tttatgtaaa gtacaccatc tttaatttct ctaaatgggg
    15601 tatgggtatg gccaaatata actatatcag catcaacttc agttgccttt ttttctaaca
    15661 tattagttcc atattttaca ccatacttat ctccatggca taagaatatg gttttatttg
    15721 ccacttcaaa gacaacttct tcctcaacag catcaaagtc acaattacct ttaactgcaa
    15781 taatacctac attagtcatg ctatgaatat atcttgaatc agtaaagtta tctcctgcat
    15841 gaattattag gtcacattct ttcaaatatg gtattgtttt ttccatattt ttaatcatca
    15901 tatgtgtgtc gcttactatg cctattttca ttacttcact acccttttta taaactcttg
    15961 tttcataagt tttagtgcgt ttgctctatg actgattgaa ttttttataa cactaggtat
    16021 ttcaccaaaa gtcttatcat atccttttac tataaataag ctatcatatc caaaaccatt
    16081 tttacctttt tcttcaaatc ctatcattcc ttcacaaatt cctcttacta caaattcttt
    16141 tccatcagga aaaactactg ctattgcaga gacgaatctt gcatttcttt tgctcattgg
    16201 tacattttgc atagctttta acagtttttt tctattttct tcatctgttg catgttctcc
    16261 tgcatatcta gctgaataaa caccaggttt tttgcctaaa gcatctactt ctaagccaga
    16321 atcatctgat attgctataa gtttagtctt ttttgctatt gttctagctt ttatcaacgc
    16381 attatgctca aatgtttttc catcttctac tatctctata cctgctaaat caacatcttt
    16441 taaagagtac actttatatt caaaatcttt taagatttca cctatttctt ctagcttatg
    16501 agcattatta gtagcaatca ctacttcatt accataatcc atacccaata tctcatctga
    16561 tatttcacct aaagcttctc tttgaagcct tattaattct ttattccctt tttcacctaa
    16621 ctctaacaat aaatttaaat ctgctctaga aaaaggtttc tcttctcctg tcccctgtac
    16681 ttctacaaac tcacacttat cagtcattat tatattcata tctacctgtg ctttagaatc
    16741 ttcttcataa cataaatcta gcatgtgtat tccatttaca ataccaacac taattgcaga
    16801 cacaaaattt gttattggca tctcttttat tgtctttgct ttatataatt tatatattgc
    16861 ttctgcaact gctacaaatg cccctgttat agatgcagtt ctagttccac catctgcctg
    16921 aatcacatca caatctaccc aaatagttct ttctcctaat ttattcaagt ctacaacaga
    16981 ccttattgtt cttcctatta acctctgtat ttcttgtgtt cttccatcaa tttttcccct
    17041 agatgcatct cttatctttc tttgttgtgt tgctcttggt agcatagaat attcagcatt
    17101 tatccatcca gtaccactat ttcttaaaaa aggaggaact ttttcttcca ctgatgcagt
    17161 gcatataacc tttgtctctc ccatttctat aagaacagaa ccttctgcat actttgtata
    17221 atctctagtt atctttacag gtcttatctg ttcattactt ctatcataac ttctggtcat
    17281 tttttatatc ctttctcata ttttttattt tttataaatt tatttttata atttttaatt
    17341 ttgtcaaata ttaattattg tcatttttcg taatcttatt agcttactga actattctat
    17401 cattaattat agtagttttc tactaaatta agcgactttt taactctcta atacagcttt
    17461 tacttcatct ttcgatgata actttaataa ttctaaaaat ctctcttcat ctataacttt
    17521 aattcctaaa tcatttgctt tagtaagttt agaaccagct tcttcacctg ccaaaacaaa
    17581 tgttgtcgat ttactaacac tagatgtagc ttttccacct cttttttcta tcatatcttt
    17641 tgcatcattt ctttttaatg taggaagtgt accagtcaat acgattttca taccttcaaa
    17701 tattttttct actttttcac ctgtattatc caatgatttt gtatttactc ctacattttt
    17761 taacttgttt ataacgttca tatttttgtc ttccttaaaa aactcgacaa cgctgtttgc
    17821 cattatactt ccaaattcct ctaattcttc tagttgctca ctagttgcag aaattacttc
    17881 atctaaatcc ttaaagttat atgcaagtat cttagctgct ttaactccta taaatttaat
    17941 acctaatcca tttataagtc tccataaatc attttctttt gatttttcaa ttgaatttat
    18001 taaattgtca gcagattttt cgcccattct ctctaggtcg actacatctt ccttttttat
    18061 ataatataaa tcagatacat cttgaataat tttttcattt aatagcagtg taattataga
    18121 ttctcccaat ccatctatat tcattgcatc ccttgacaca aagtgtataa ttccccttct
    18181 tatttgggct gggcaagaca tattgataca ttttacagca gcttctcctt ctaatcttat
    18241 tgttggctct gaacaaactg gacacttttc tggcatttta aaatctattt catctccagt
    18301 acgttcttct tttataactt ctaaaacttg aggtattatg tcccctgctt tttgaactaa
    18361 tactgtatca tttattttta tatctttttc tcttatataa tcttcattgt gaagtgtagc
    18421 tctacttaca gtggtacctg caagtctgac tggttcaaga attgctgaag gtgttattgt
    18481 accagttctc ccaacttcta ctattatatc tactatttta gttttcttct tttctgctgg
    18541 gaatttatat gcaattgccc atctaggact tttggctgta tatcccattt cgtctctttg
    18601 ttttatattg tttactttta ttaccatacc atctatttcg tagtctaaat tacccctgtt
    18661 atctgtccag tattcaatat gctcaataac ttcatctata cttttacaaa ctttataact
    18721 ctgacttact gaaaatccta gtttttctaa gtactctagt gattcactgt gactttctaa
    18781 atcgtattct tctatatttt ccatattaaa tacaaatata tctaatggtc tctttgctgt
    18841 tagttttggg tctaattgtc tcaatgaacc agctgcaaga ttccttggat tagcaaataa
    18901 tggctgttct tgttcttctt gttgttcatt tacttttcta aaattatctt ttgatatata
    18961 tacttctcct ctaactatta gttctttttt atcatttatc ttaagaggta tgctttttac
    19021 tgtcattaag ttttgagaaa tatcttctcc tacaactcca tctcctctag ttgctccttt
    19081 ttcaaactct ccattgttat aagttagacc tacagaaaga ccatctattt taaattcaac
    19141 aacatattca acattttctc ccacatattc ttgaactctc ttatcaaaat ctctcaaatc
    19201 ttgctctgaa aaagcatttg ataaactcaa cataggagtt ttatgtacaa tttgattgaa
    19261 cttatctaat ggcttacctc ctaccctatt tgttggagaa tcaattctct ttagttctgg
    19321 atgttcttct tctaaagaaa ttaactcctt cattaactta tcgtattcat aatctgatat
    19381 ttctgggcta tcttgattat aatacctttc attatggtag tttattgtct ctataagttt
    19441 attaatttca tcttttacgc tcactttttg cacctcttca tatttttaaa attaaattat
    19501 tttgaaattt ccctataatt aattatctcc tatttatata ttttttagta tatcactttt
    19561 tgggctttaa atttattaca aaaaaaactc ttattagtat ctttaatacg actaataaga
    19621 gtttttattt ttatcaaaat tttttatttt taatagcctc ttgatatgtc tacaacatta
    19681 tctacaggtt tattctccat tatatagtgt ttcaaattat tataaaccat attaaatgtt
    19741 ctctctttgt ttttatctga cacccaagaa ttatgaggag ttactatgac attttcgcac
    19801 tcccacaact tattgtcctt gtttaaaggt tcactttcaa atacgtctaa tgctacccct
    19861 ctaaatttct ctacacattc ttctaaatct ttctgattaa ctgtatttcc tctacctaca
    19921 tttataaata cagaaccatc tttcataagt ttaaacatat ctttgtttac tattccatct
    19981 gtactttttg tagaaggcat tgctacaact actatatcac attcttcaaa tacaatattc
    20041 atatcctcag tagcaaaaca cttatcaaag tattttttac tacttccatc agtattgaca
    20101 ccccatattt ctacaccaaa agcttttaat ctttttgctg cttctgaaga tatagtacct
    20161 gttcctaaaa atccaactct ttgtccatac aattctgata cagaaaaatc catcttccat
    20221 tctttatttt gttgttgttt aaaaaatttt gcactatttt tatatatttc taaaatatac
    20281 aatacaatac tttcaccaat aggtacacta tatccgcctc tattattagc tatcttaata
    20341 tttctcttca atacctcttc ttttggaagt tggtctatac ctacactagt tgtctgtata
    20401 tattgtaaat ttttcatctt agaaatatct aatctctcaa atggattgta tgtaactagt
    20461 acatctgctg tatttacatc ctcattattt tcaatactat cttcagagta atgtatgaca
    20521 tcatagccta attctcttat tttatcaaat ttttcttttc cataatttat tgtaaataaa
    20581 actttcatct caaatctcct ccatctaccc acatttaaaa ttttctattc taaaatataa
    20641 tatgatactc aatgtacatt agttaaaatt actataagat atcttaaatt tacttatgtt
    20701 caattgtttt tcctaaagac atagcattac gttcttgaac taaattttct attaaattat
    20761 tcaatgtcca atcaatagat gtctctgtta ccatagctgt aaaaggtcta tttattctca
    20821 ctttttttag cccttctaaa aatgcattta cttgtgtact tggagtgtta ttaaatatta
    20881 cagacttact cttaatccca ttttcacatt catttgatat atttccatct aaaatgtctc
    20941 ttattatatt ctctccattt ttatcactta agatgatatg gtctcttatt ccagcaaagt
    21001 tacttacatt tttaattaat gataattctt ttttattaaa gtttacaagc ataatacact
    21061 tcctattgtg tattttatct aggttattat tatttatttt ttcaaatgac attttatcca
    21121 tcctttcatt tatttatata ctttaattta ccccatacat ttaaaataat caatttttat
    21181 agttaatttt tatattaata cccaaattat atttaaatag ttaggctatc caaaactaat
    21241 atataaaatt agaataatta gattaatatc tacaaatcat aacctaaagg agagatacca
    21301 tgaatacatt actaaacaat aaatttagca ttaaaaactt ttcaaatgct tgggttatag
    21361 tacttggttg tatgttaata caagctgttc catttagtat tgtagcaagt atacagcctc
    21421 aatttataag ttatgttgta gaaggagaag gctttagttt agcttctttt tctctaatat
    21481 tcactattgg tactattgcc tcagcaattg catcaccttt tataggtgta ttattttcta
    21541 aagtcaatat taagatacta tatttattag gttgtataat ttctagtatt gcttttgcta
    21601 ctttttctat atgtactgaa ctatggcaat tttacactgt atcatgtatt gttcaaattg
    21661 gcgctacaat tatatctgct ataggaatac ctgttttaat aagtgcttgg tttgatgaag
    21721 aaagcaaagg aaaagctttg ggctttgctt ttgctggtgg ttctattggt agtatatttc
    21781 tacaaccact tgcagttcgc ttattagcaa ctcaaggata cagtcgttct tatctaatat
    21841 ttggaattat agcattaata gttggtatac ctgtaatatt attcatactc aggatgccta
    21901 aagatattaa tgaaaaggta aaatctaaag gtaaaaaaga gaaagcatct gatacaattt
    21961 ctccttcagt atggggttat acattaaaag aagctaaaaa aattaaatat ttttggatta
    22021 tgactattgg atttatattt gttggtatat atgtttcatc attatctgta caatatccaa
    22081 cttatcttag aaattatcta aatcctattc taataggaac agtaggctcc acatttgcct
    22141 tatttgctct cattggtaat ttatttggag gattattgtt tgataaattc ggtcaaacaa
    22201 agccacttat tatatctttt gtattggttc ttatagcaac tttatcatta ctattggtag
    22261 ataaatcttc tacttttgca tttgtatttg ccattttgaa aggtctttct gtatttgctt
    22321 atatgattgg tcctgcttat ttaactggct ctttctttgg tcaaaaggag tttggtagca
    22381 tatatggaat cgtacaatta atttttgcag tgggatttgc attaggttca acattatttg
    22441 gattgttagt tgataatttt ggatacagat tttcttggtc tattataatt ttatcagtta
    22501 taattgccta tactttactt attataactt ctataggaat gaaaaaattg aataaagaaa
    22561 gattagataa actaatgcaa taattgattt ttagatatat aaatattata ataaaaaaga
    22621 tggagctttt aatcataaat aaaactccat cttttttata ttacaatata gctaattttc
    22681 tcttattttt aactttacta tctatatcct catccttaac tatagtaaat gccttagttg
    22741 gacaaacatt tacacatgca ggcccttctg gcgattctat acaaaaatca cacttatttg
    22801 ctgtcattct ttctctaaag caaagctttc cttcatctac atcttttaat gtaactatgt
    22861 ctattgcacc tataggacat gctaacatac aagtcttaca tcctatacaa ttttcttcat
    22921 ttatttttat tgtgttacca accctaacta taccaccatt tggacatgcc tttgcacaag
    22981 gagcatcttc acaatgtcta cactgtattg gagcacttac ttcttttgtc tttatgacag
    23041 aaagttttgg attaaaattt atttcatctg gattttggta aaaaatatct tcatctgaat
    23101 gtgcaactac acatcctatc atacaagttc tacatcctat gcatttatca gggtctgcta
    23161 taacaaaata gttcatcact tagccacttc ctttcctata caatatgtag tgtgtaatag
    23221 atgatgagat ttttctccta atggttctac cagatattca tcatacagtt ttttaatatc
    23281 aggattctca tgagattttc taattgctaa atgttcatca tgcacgtatg ttgcttttgt
    23341 tctattttca taagccaatt ccttatattc ttctagtaaa atttttggtt gacctccacc
    23401 acttacacac ccaacaggac aagtcataac ttcaataaaa tctacatcta attttccttt
    23461 ttccaagtct tcaagaactg gtattacatt ttttaatcca cttactactc caactcttaa
    23521 gtctaagtct cctattttaa tagttgactt tctaaaacca ttttctcctc ttacttgttt
    23581 tacttctaca tcaggaatac tttctccagt tataagctca tatcctgttc ttatagcagc
    23641 ttccataacc ccaccagtaa cactaaagat agttccagct ccactataac tacctaaagg
    23701 actatcaaat ttttcttctc ttaaattttt aaaatcaatt cccatgtctt ttattaaata
    23761 agctagttct ctagtagtta atactacatc tacatctcta tatccactag aatccatttc
    23821 ttctctatca cattcatatt ttttacatgt acatggcatt atagaaacac taaatatctt
    23881 tgatgcatct acattattta tctctgcacc ataagtttta aatattgcac cacccatctg
    23941 ctgaggtgat ttacaagaag ataaatgatt agttaattta ggataatttt tttccatgaa
    24001 ttttacccaa gctggacaac aagatgtaaa cattggaaga gttccacctt ctgtcactct
    24061 tttaattaat tcactacctt cttccattat agttaaatct gctgcaaaat tagtatcgta
    24121 gactctatca aaatttaaag ctctaagtgc tgctgccatt ttcccagcac ctaagtatcc
    24181 taaataatat ccaaaatctt ctcctaaagc aactctaact gctggtgcac attggaccat
    24241 agtgaataca tttgggtcac ttaaagcttt cttcacctta tctatatcac atacattgta
    24301 tgctgcaaat ataggttcat ttatagactc tggtatctct ctttcttgtt ttttctcttg
    24361 taaaaactca aatccttcat ctataactga ggcataagat ttacaagttt gaacacattg
    24421 accgcacata acacatctat ctaaatttat ctcttgtggc tttccctctt caccttcaat
    24481 agcatttact ggacagacct ttgaacattc tctacatcca gtacataaat ccttatctat
    24541 atttattatc ataaacgtca cctacccctg tatcctttat ttatttgtta acaataaact
    24601 aagtgcagct tgtctattct tagctttttt gtcatctatt ggagtaacaa gttttaatgc
    24661 ttcctgagga catgcactta tacaagctat tttttcattg tctttacata agtcacattt
    24721 ataagctatc ttcttatttt catctaaaat tacttgttct acttctttac catcttcata
    24781 ttgtggaagt aagtctatag ctccaaaagg acatgctagc agacaagttt tacatcctat
    24841 acacttttct tcatttacag acataatatt gttttcttta actatagctt tttgtggaca
    24901 tgagtttaaa caaggagcat cttcacaatg tctacactgt attggcatac agaaattgtc
    24961 accttttact aagtaaagtc taggtataac aggtatatca actgttccaa ctgtataacc
    25021 cacattatta tgctgattat gcattgtaaa acaagctact tcacaagctc tacaacctgt
    25081 acatttgttt gggtctgcta ttacaaaaga gcctatttta tttttcatat tatcccacct
    25141 ttcaatttgt atatttccaa ccctctagtt attttcatca tatgtctact tactttcatc
    25201 atatatattt atatatttca ctattttctc agtacttata tttcgtttac attttttgca
    25261 caaattgtat gtgttattat acaccttatc agtatcatca attaatactc cacagatttc
    25321 acactttgaa tatctttgct cttctttttt agtacacata tattcattct cactttttga
    25381 taactctctg tggatttgca taaatattca tccgtcttcc tcttacaaat ccaataagcg
    25441 ttatatttaa ttttttagaa agctctattg ataaattagt cggtgctgat tttgatacta
    25501 caataggaat ttgagtcata gctgctttta atatcatttc caatgatatt cttccactta
    25561 cagccacaat tttatctttt aatgttatgt catttaaaac acaaaatcca atagccttat
    25621 ccattgcatt atgccttgct acatcttcac aagtgactat ttttttatca aaattaaata
    25681 cagatacgct atgtacccca ccagtatttt taaataattc tgatgaattt aaatttttat
    25741 ccattatact gtaaatcgta tcataattta tttttatatt gctctttaca ggagcacatg
    25801 ttatatagtc tagtgaattt aaaaatataa tttgctcatc ttgatttttt tgtttctctt
    25861 gaatagttac ttttgcaaaa cgttcactct catttatctc aaattttaat aagctttttt
    25921 tgttttctat gtatcctttt gttttcaaga atcctactat aagttcctct aaattatatg
    25981 gggtacataa aaatgtattt acatatttat catttaaaat aaaactaagt ggatattctg
    26041 caattatttc ttcattatct attgatactt catgttcatt tattttgctt acttctacat
    26101 taaaagaatt taaatatttg tagtccacta gactataact attttcaaaa actttatcct
    26161 tactattttc ttgtaattta gtttttgagt atatattgtt cataaaatat tagcctttct
    26221 gccttttata aatcttaaat ctaataaatc attagatatt tgtagctgtc attttgtctt
    26281 tcaaactttg atactcttct cttacacatt tttctgctaa ttcttggtct tcaagttttt
    26341 caagtttaac agcacaatat ttatactctg gtgttttaga tatagggtct aaatttgcta
    26401 ttgtaagttc attgcaagct ccaacccacc actgataagt catatatgtt gcaccttcct
    26461 taactctatc agtaactgtt gctcttgtta ttacacttcc tcttcttgaa ctaattctaa
    26521 ctaattcatc atcttcaatt cctaattttt cagcatcatt agaatttatt tgaacacgtc
    26581 ctggttcatc ttctaatgaa ctaagtgttc tacaattacc agtcattgtt cttactgaat
    26641 agtgtccaac ttctcttaca gtacataaac taaatgggta ttcatcatct tcaacttcca
    26701 tagggggtct ccattcagca gcgaacaaat tacctttacc attaggagta gaaaactttt
    26761 gaccttcata cagatacata gttcctttat cttccatact ttcactctta caaggccatt
    26821 gaacgcatcc ttgagtttct atcttttcat aagtagcacc taagaaactt ggacataatt
    26881 gtctaagttc gtcccatatt tccttagtat ttttataatt cataggatat cccattgctg
    26941 tagaaatttc gcttataatt tgccagtctg gttttacatc tccttgtggc tctatagctt
    27001 ttctcatcaa ttggaatcct ctatctgcac atgtatatac tccctcatgt tctccccaag
    27061 aagtagctgg aagtataaca tcagcatgaa gtgctgtctt attcataaat atatcttgaa
    27121 caatgacaaa ttccaattca tctaatgctt ctctaacttc tgatgcatct gggtcacttt
    27181 gtactgggtc ttctccaaat atataataag ctttaagctt tttctctttt agtactaaat
    27241 ttggaacttg agttaaacta taaccattat taggagataa ttttaccccc caagcttttt
    27301 caaacttttc tcttatctta tcatcagtta cattttgata gccaggatat acattaggaa
    27361 gagctcccat atcacaagct ccttgaacat tattttgtcc acgtacaggt cctattccaa
    27421 cgctttctct accaaaatta cctgtaagta gagcaattga tgcaagtccc ttaactacat
    27481 caacagcttg accaaattga cagacaccca ttccataaag tatcatagct tttttacctt
    27541 ttgcatattc tctcatagct tttcttataa gctcttctgg gattcctgta atcttttcag
    27601 catatttagc tgtatatggt ttaacaattt ctttatactc atcaaatcct tgtgtatgat
    27661 tttgaacaaa ttctttattg taaagacctt cttctattaa tacatttcca aaagcattta
    27721 ctaaaaccat gtttgttcca ccttttatag gtagatgtat atcagcaatt cttgcagatt
    27781 cagttactct agggtcagta acaattaatt tagcaccatt ttttttagct tttactattc
    27841 tatttgccac tattggatgt gaatctgctc cattatatcc aaatataaat aaaacatctg
    27901 cattttctat ctctggtata gaattagaca ttgcaccact acctaatgag taagccagac
    27961 cggctacaga tggtgcatgt cagacacgag cacaatggtc aacattatta gttcctattg
    28021 tagctctcat aaatttttgc attatatagt ttgcttcatt accaggtcct cttgcagaac
    28081 ctgttcccat aatagaatca ggtccatatt tttctttaat ttcatttagt cttgaagctg
    28141 tatagtttat agcctcatcc cattcaacct cttctagtac accttgtttt cttatcattg
    28201 gcttttttag cctaggtgtt agaattttag ggtcatttag aaaatcccat ccataacgac
    28261 cttttaaaca caaactttct tgatttgttc taccattagc cggttcagct cttaatatct
    28321 tattatcttt tactactaga tataattggc atccagctcc acagtatgga caaactgtta
    28381 aaattttttt ctccatacaa ttcccccctt agatttatcc cctgataagt aaaatttatc
    28441 ttaaagataa tgagtgtttt tataatatgc aaaatcataa atattttgca atactatcta
    28501 ttaaattcaa caattttctc acaattcctc ttaaatttca aaaaaaatat gtcataataa
    28561 tctttatatt tcaaccattt aattaaaata ttctagttct tatgacatat tttttaatat
    28621 actcaatata tattctttaa acttatttag ttttcactta aaacaatatt tctgccaatt
    28681 ctgtttttca ttctatagtg agtaattaca gtaaatattc cacttccaat cagaatcaaa
    28741 tagtacataa atccaccata taaaaatact gcatatccca tcaaaggttg agggaatact
    28801 gatttgaata tagtgaaaaa ggctaattca ttagctccta cattcccagg tgttggtatt
    28861 ggagatattg ccatatataa aaatgcttgt aatgtcagta tataaatata gctataacct
    28921 tgtaaattaa atgctttata tatccaaaat gaaacactaa agtaagcact taattgaata
    28981 aaagttacta ttatagttga aattaatacc tttttattct ttgcaaaaaa atttattgct
    29041 ttactataat catctataaa actttctatg gattcaatct tattatctaa aaattttaaa
    29101 aacttaattt ttgataaatg ctttatagta attctcataa aatattttat tttttcagga
    29161 tttaaaataa ctaatattat cataattaag acaaatgaat taatggctat ccctagaaac
    29221 actagaggca taatcatttt catttgtttt tctaacatag caaaattcat taaaacaagt
    29281 attgtacaat aaaaagtaac tactatttgg aagataatag acttattggt aacaactgca
    29341 cttgccttac taagtggcat tttacatttt ttaagtacat atatctgtac tggttggctt
    29401 cctgaagcaa aaggagttat taaattataa taaaatccca taatggctag cttaaaacca
    29461 ataaatctaa tattaacttt gtgagtgctt tctataatta tcttcattac tactccttca
    29521 agcattatgt gacacattat tgccaaagca cctatgaata aaaacttctt atctaccata
    29581 accataacat ttgatagcat tttaatatcc aatgttttaa acactaggta aattgttata
    29641 cctattaaca aaaataaaaa tgtatactgt agtaaactct ttctaatatt ctttagtcta
    29701 tccattagaa ataaccatcc tttgctcaag atttatacta aatactatat tattagtata
    29761 cactatgaat cttaatattt tataacaaaa taccttacaa ttttgtcatt tacaaaaaat
    29821 attaatctat aaattaaatt ttaatatata gattaatatt ttacaaacat tttgtagata
    29881 tatataatat tttcactaaa caacacttat acttattaca cccatttata ccctatcccc
    29941 catacagttt ctattgtata aatatcatat tgttttaatt tgcttcgtat attttttata
    30001 tgctctgtga tagtacttat atcactttct ccatcaaaac catataccga ctcatatatt
    30061 ctttcttttg aaaatacttg tcccttattt tttgctagaa attcacatat tagatattca
    30121 cttttagtaa aattaatttt tttaccatca attgaaactt ctttgcctaa aaagttaaat
    30181 tgaacatttg agatagttaa taaattcttt ttttctctac tttctcgcct taaatgagca
    30241 gttatcctag cccttaattc tcctacacca aaaggtttgg ttatatagtc atctgcacct
    30301 ataccaagac cgtacataat atcactttcc atattttttg ctgtcaaaaa cagtattgga
    30361 caatcaacct tatttcttat agttttacat acttcaaaac catccatctt aggcatcata
    30421 acatctaata ttattagatt aaaataatta aaatccatgt tcatagcttt ttctacatca
    30481 ctaattacct ttacttcatg tccatctctt ttcaacacat tttcaatcaa ctttaacata
    30541 tctaactcat catctactac taatatctta gacataataa ctcctccatt tatccgttta
    30601 atagtattct aatttatata tttaataata tctttaaaat tcacattaac cataatactc
    30661 tcatattata gcttacaata attaattact attttacaaa taaaatatct tagatacaaa
    30721 aactttatat ttcaaaactt tatattcatt ttacacgtat ttac
//
LOCUS       DAEHWM010000042        29251 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.043, whole genome shotgun sequence.
ACCESSION   DAEHWM010000042 DAEHWM010000000
VERSION     DAEHWM010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 29251)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29251)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29251
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.043"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..897)
                     /locus_tag="KNP36_001969"
     CDS             complement(<1..897)
                     /locus_tag="KNP36_001969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873842.1"
                     /translation="MRITKTTFNDVFSNDANGSIIKVEKYVDKKCASVFEILTYTIIV
                     TNTSRYKTGNIFFKDYISKYIEFINNTVKVNGIIKRGLDPQQGFYIGRIDASCKKIIS
                     FKSVVLPNSAHRIIKNSANIYYYYKCNLDKFPTRISIESNRVYTNVNKIVFKQLNISN
                     TLKAPKNLRDILKVNVNSKIFDVKPMKNLINKGSNLKLCNLIVFGYIEVEIDYSCKNR
                     SNFKTVNKSNDIKKDKYYKNDIQNNNENINDCKKQISFGDNKVKKITKTFGFSCFICS
                     PVGIIYEDMKNINIKIEHTSINE"
     gene            complement(925..1416)
                     /locus_tag="KNP36_001970"
     CDS             complement(925..1416)
                     /locus_tag="KNP36_001970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873843.1"
                     /translation="MYENNKVIYNLERCEKLEKTLYLSQFNTYKNFKLASKKTVINSL
                     ETYVYNMNINNISLVDTIECISLEDEQLTGKKLILVGDIDIDAILDYAGNKRNRNSSK
                     KNTFKLKIPFSTFIQMPRKIENKDKINLKYLIQDITSSILDDNLFISVTAIISYENSS
                     KIE"
     gene            complement(1859..2752)
                     /locus_tag="KNP36_001971"
     CDS             complement(1859..2752)
                     /locus_tag="KNP36_001971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBF0873844.1"
                     /translation="MKNKKFIVIILIISILIGVLVKEYSSREIKKDDINVSKYIKYAD
                     LASKNNAQVNWKYVASIVAVLNKNNLKNVKDSQIQEVSDLFVKNFSKNNKINKLSDIL
                     DELEFSNRQKRLVDNYIDNLKDYGIKPERLKSDTKYMKFIDEIKTEAIQNYKDYKILP
                     SITIAQAIIESSWGKSTLAKQYNNLFGIKADAYWKGKSVTLETKEHLDTIIDDKFRIY
                     DDKNESIKDHAKFLATNKRYKNNGVFDAKTYIYQAKALEKAGYSTAKDENGNSIYAAR
                     LIELIQQYNLQLIDSEIQSEM"
     gene            complement(2977..5262)
                     /locus_tag="KNP36_001972"
     CDS             complement(2977..5262)
                     /locus_tag="KNP36_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 65 protein"
                     /protein_id="HBF0873845.1"
                     /translation="MKCLFSNVDEWKIIQDKIEIKENRLAESIMSIGNGYMGMRGNYE
                     ENYSGDTHKGSYIAGVWFPDKTRVGWWKNGYPEYFGKIPNSVNYIGVRIFIDDVELDL
                     AKCKVEDFHRELDMKNGILNRRFIVNINDKKFEVRVTRFLSISVKELAVIKYSIKSLN
                     SNTKIKFVPYLDSNIKNEDSNYEEKFWNGISSSSLEYKGSILSRTKENAFNTPVFTVG
                     SMMYIKTNGDVEAVSHESDYNYCENSITMDVLKNEVASIEKYVSITSTRDYKESELLR
                     KCEDILNRELSKSYDDILNEHIKLWNKRWESADVKINGDKSSQQGIRYNLFQLFSTYY
                     GEDSRLNIGPKGFTGEKYGGATYWDTEAFCVPVYLGVADKEVTRNLLEYRYNQLEQAK
                     DNAKKLGLKGALYPMVTFDGVECHNEWEITFEEIHRNGSIVYAIYNYTNYTGDYKYIK
                     EKGIDVIIEIARFWASRVHLSTKKDLYMIHGVTGPNEYENNINNNWYTNYIAKWCLDY
                     AVENILRLEKECNECIDRNNVTREEVEFWKIISNKMYLLYDEELQIIIQNDNFLDKEF
                     VEVKDLPKENFPLNQNWSWDKILRSCFIKQADVLQGIYYFGNRFTKEEKKRNFDFYEK
                     YTVHESSLSSSIYSIIASEIDNLEKAYELYSRTARLDLDNYNNDTNDGLHITSMSGSW
                     LSIVHGFAGMRTWNETLSFDPKLPKEWKNYSFNINYRDNIINVDVCSDLIKIENLKGK
                     PIKIIVYGKKYILEKCIKIDK"
     gene            complement(5259..5939)
                     /gene="pgmB"
                     /locus_tag="KNP36_001973"
     CDS             complement(5259..5939)
                     /gene="pgmB"
                     /locus_tag="KNP36_001973"
                     /EC_number="5.4.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-phosphoglucomutase"
                     /protein_id="HBF0873846.1"
                     /translation="MIEAFIFDLDGVITDTAYYHYMAWRKLAHKVGIDIDTKFNESLK
                     GISRMESLDRILEFGNKKYSFSEEEKVRMAEEKNNYYVSLIDEITSNDILPGIESLLI
                     DVKSNNIKIGLSSASKNAINVLNHLGISDKFDFIADAGKCKNNKPHPEIFLMSAKGLN
                     VNPQNCIGIEDASAGIDAINSANMFSVGVGNYENLKKANLVVDSTNQLKFEYIQEKYN
                     EYIVRRII"
     gene            complement(6163..8046)
                     /locus_tag="KNP36_001974"
     CDS             complement(6163..8046)
                     /locus_tag="KNP36_001974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
                     /protein_id="HBF0873847.1"
                     /translation="MSNKNKENITLSNQIKGTIQNSLTKEAILHIPMSNYAYGYDRET
                     LHIRLRTKKNEAKRVILRIGDQYVWDKGGAGGGNLNASGVGWSGGTNIVMSKEVETEL
                     FDYWIAKCKPLNKRSRYGFIIEGQEEKLLFTEKRIIELGNENDEKELCEIGNFFGYPY
                     LNYIDIPKVPNWVKDTVWYQIFPDRFANGDPSINPEGVDKWGAIPTRDNFTGGDLQGV
                     IEHLDYLSDLGINGIYFCPITIGKTNHRYDTVDYMEVDPTLGDKETLKKLIEEAHKRN
                     IKIMLDAVFNHIGYYSKQWQDVVQNKENSRYKNWFYIKDMSKIDTPIEQIDEKNIPYE
                     TFGCEKYMPKLNTENSEVIKYLLDVGKYWIQEFDIDAWRLDVSNEVDHVFWRKFREEV
                     KKVKPDIYILGEIWHGSLPWLMGDQFDSVMNYLMSEAMKKFFCTDEINAEEFKYMIND
                     VMVSYPIQVSEVIFNLLGSHDTTRILTYANGNIDRFKLAYMFMFVQTGCPCIYYGDEI
                     GMEGELSSISEGQRKCMEWNEEKWNKDIFDFMKKIIRLRKENKELRSISNEWVLADKE
                     NGTIILKKESISIIINNSSKNIILTLPDYLANKKVKDLYEEEIVDLKEELMLEKYKFI
                     ILK"
     gene            complement(8304..9125)
                     /locus_tag="KNP36_001975"
     CDS             complement(8304..9125)
                     /locus_tag="KNP36_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ family protein"
                     /protein_id="HBF0873848.1"
                     /translation="MNLIDNHIHTNFSSDGKDSMEDTIKKAISIGVRYLTFTDHLEHD
                     EDRGFCINYNDYVPVFNKFKEKYKKDIELLLGVEVGYRKHLKNEIEEIINSNPFDFVL
                     CSTHTIDNVPVPSKAYFKGLSKEDAYYKYFNSILETNREFGDYNIYGHLDYISRYGIY
                     SDNRVIYNDFKDVIDEVLKSIINNGSGIELNTSGYRYGLNAIHPNEDILKRYKELGGF
                     IVTVGSDSHRVEDICKDFDVAYDMLKYLDFKYVSLFKERETYFVNIEKVKSNNIA"
     gene            complement(9316..9669)
                     /locus_tag="KNP36_001976"
     CDS             complement(9316..9669)
                     /locus_tag="KNP36_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873849.1"
                     /translation="MKKSNIFSIIFPTVIMVLMFLTFATDIFNIPDIQSKSIFVVGMV
                     LIFPISFLIQGIICVLNKTNWILSLIVSLVTYIVLMYIFLNDSAYIYVLLYTAFYMIG
                     HITAKLYYKIKTFKN"
     gene            complement(9711..11153)
                     /locus_tag="KNP36_001977"
     CDS             complement(9711..11153)
                     /locus_tag="KNP36_001977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBF0873850.1"
                     /translation="MRTIRRVLALGLTLAIFLINVPNVDALTSDTIKGNNIYETAGLI
                     ADKKSYDTAIMVNMDNSIADGLSASGLAGAVDAPILLAQKNKIPNETKQRLKNVKKIY
                     IIGKELSISKSVETELKNTGAQVTRLGGDDRIKTSYSVAKEVNGIKKVDEVILTNAYK
                     GEADTISAAPVSVRDIAPIVLTDGKSVPFSTSNVKTYAVGGSISMSTSLVNKTNAKRL
                     GGSDRYDTNKKVIKEFYPDASEFYLSDGYDLVNALTGSTIAKENPIVLVSESSDKSIL
                     AGADKITRLGSISDSVYNKCVSAAQNNGDSSTKGESPMKNETSILGQPTASLEACLKW
                     AKSKKANDLFIELIPILYDTAVQEGVNPVLAVAQSAKETGFCNFGGVLDASFKNPCGL
                     KTSVGGSDTDKNAHSRFDTWEEGILAQIQHLCLYAGQDGYPLSNPVDPRHEKSLFGKA
                     KTVESLSNNWAGGQYGQDLVRMMGEIEATK"
     gene            11829..13040
                     /locus_tag="KNP36_001978"
     CDS             11829..13040
                     /locus_tag="KNP36_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HBF0873851.1"
                     /translation="MSNKQGSNIKDVKIKNKLIILKLLSTNTPMSRVDLAKSTGLTKM
                     TLSNLVTELINENMIREIESSTLNAHSSGRKPILLDISNISPCICGILIRRNICKVII
                     SDLKGNIVKQLSETYPKFLSNDVLKDIIKRMFTKIMKINKRDIIGIGISSIGPVDDIN
                     GTILNPPDFGNVSNLNIVDFIKEMSDLPIFLINDANSGALAEKMYGLGKNISNYIYLH
                     IMNGIGAGLVLENKLHTGNLGQSGEIGHTSINFSGPLCSCGNNGCLDYYTSVSNLIKR
                     IESLSHIYPNSPLINCKDFSLVKLIDEANNKDSLAMFLLDEFCTYVSYALVNTLTLID
                     CSSIIIGYDFNIPGTFIENTLLKKLTASASFSKYKKISVRHSNFGANAPLIGSIAIVS
                     YNFFNGSINFY"
     gene            13132..13647
                     /locus_tag="KNP36_001979"
     CDS             13132..13647
                     /locus_tag="KNP36_001979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferritin"
                     /protein_id="HBF0873852.1"
                     /translation="MISAKMEKLLNEQINHELYSAYLYLSMSSYLEAEGLKGFSNWFY
                     VQYKEETDHAMFFYKYLHNVGGKVQLDAIPMPDSDFTSAMDILERTLAHEKKVTALIN
                     NLAAVANSESDFRTSQFLLWFISEQAEEETNCEDNIKRVKLAGEGGLFFVDQEFANRT
                     YAAPTNPPVTI"
     gene            complement(13914..16013)
                     /locus_tag="KNP36_001980"
     CDS             complement(13914..16013)
                     /locus_tag="KNP36_001980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate--CoA ligase family protein"
                     /protein_id="HBF0873853.1"
                     /translation="MSLEKLIRPKSIAIVGVTDKLGFGRSAALSIVKSKETDRVYYVN
                     PKREELFGRKCYKTIQEVPEVVDCVVVCTPRNVVPSVLKDSGELGTKAAVVYASGFAE
                     EGTEEGTDLENQLIEISNTYDMKILGPNCMGLLNCIDKVNLWAGGSKWDLDTKKPGIG
                     IVGQSGFITAEIVSSDYFNISYGFSTGNGNIVTLEDAVDFLVDDDYASVIAIYLEGLK
                     NPQKFIDALKRAAQKRKPVIILKSGRSEKGAISAASHTGNLAGSSKAFESIFEKYGVI
                     SVENLEQFMCLAQAFSVLDGNLPANSNFAAINFSGGENTICADLAEENGVELAEISSE
                     TKEEMEKYLPGFATPKNPLDATTALFHEKDMIVGLLHTFEKDDSVGFTMVGANIRDEE
                     NEMHETLCKAVSEAREQGLKKPVFAVPTLEGNRYLDYRTRLEDNQVPIMSSVGTTFTC
                     FNKMAKFIDYDYSKRTLEFKAVKKRESNNVVALSELDSKIEMKKYGVPVPGQGNAKSI
                     DELDEILKYIKYPVVLKINSSEILHKSDVGGVKIGIKNRDEAVDAYNEILTNVKKAKP
                     DANIDGILVQEMVESGIEIIIGITNDDQFGPMLLVGLGGVFVEVFKDTTLYPLPINHD
                     EAIMMLKKLKSFKLLNGYRGSEPCDIDALADMMVKLGKYAYENKDEVKEIDLNPVFVY
                     PKGKGVCAVDALIVKYK"
     gene            complement(16137..16676)
                     /locus_tag="KNP36_001981"
     CDS             complement(16137..16676)
                     /locus_tag="KNP36_001981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoacid:acceptor oxidoreductase family
                     protein"
                     /protein_id="HBF0873854.1"
                     /translation="MEKELVFAGFGGQGVLTLGLIVAESALELGKQVTWMPAYGPTMR
                     GGKAYSVVKFSDESIGGPDMEEIDVLVAMNKPSLDYINLVKEGGTVVINTSAIDENVT
                     LREDISVVKINCQELAQKVNNPKAANIVVLGALIAKTGLFEKELALKTMCDFFEEKGK
                     GKFNVQNEAAFMEGYNNAI"
     gene            complement(16679..17419)
                     /locus_tag="KNP36_001982"
     CDS             complement(16679..17419)
                     /locus_tag="KNP36_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate oxidoreductase"
                     /protein_id="HBF0873855.1"
                     /translation="MATEKLTPSVVSIPNKFCPGCGHGIVNRIIAEVIEEHGYEKNHV
                     LTLGVGCVCNMNFSWNGDKMQTAHGRASSTAIGVKVALPDTLVMTYQGDGDAYVIGLS
                     ETLNTAYRNHNVTVFVINNNNFAMTGGQMSWTTMPGQVTTTSVNGRDIKTTGSPLKVP
                     EMVANFFDVAYVARGSVHSPKEIINLKKYIKNAIEAQLNGEGYSLVEILAPCPTNWGV
                     SLEKSIKWMEEEIVPYYALGEFKQRDGE"
     gene            complement(17421..18470)
                     /gene="vorB"
                     /locus_tag="KNP36_001983"
     CDS             complement(17421..18470)
                     /gene="vorB"
                     /locus_tag="KNP36_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate dehydrogenase subunit
                     VorB"
                     /protein_id="HBF0873856.1"
                     /translation="MKKMWKGNHAIAEAALRGGCEFYAGYPITPQTEVMEFLSHRMSE
                     LGRTFIQSENEMAAIYMVYGAYASGMRSMTSSSGPGISLKQEGISYLCANHYPCVIVN
                     VQRWGPGLGSLDSAQTDYLRDTRGGGNGDYHLIVYAPNSIQETVDLMYNSFDVAEKYR
                     VPVEILTEAALGQMMEPVEFPEFKKREGDLGWTYDGSNRDHAKVADNQKPTFCMEKRM
                     RITENEQQWEDYQVEDAEYVFVAFGIPSRTTMNAVRRLREQGEKVGIIRPITVWPFPY
                     KAFEKVSKDVKGFISVESTDTGQLVEDVALASKKVCKENVPVYGLFSGNHIPKTLQVM
                     DTYSKIKSGEIKEVF"
     gene            complement(18487..18723)
                     /locus_tag="KNP36_001984"
     CDS             complement(18487..18723)
                     /locus_tag="KNP36_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0873857.1"
                     /translation="MKRGVDMNLKINAERCKSCEYCVISCKKGALKISSKINKEGYAH
                     VEVDESKCILCGICYQVCPDNVFEIIKEEACQEA"
     gene            complement(18738..19841)
                     /locus_tag="KNP36_001985"
     CDS             complement(18738..19841)
                     /locus_tag="KNP36_001985"
                     /EC_number="2.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate transaminase"
                     /protein_id="HBF0873858.1"
                     /translation="MIEKLLRNTVKELHQYVPGEPIEKVKEKYGVKEIIKLASNENPL
                     GPSPKAIEAMIEMLKQGQLYPEPEANELRRKLAEKLDLKPENFIVANGADNVITLIGE
                     AFINRGDEVIYCNPTFPSYRTATIKNEGIPVEVPLTEDYKYDLQGILDKITDKTKLIC
                     VCNPNNPTGTIVDDKELEEFLKKVPENIITILDEAYIEFLTVPNYVDGLKYVRENYNV
                     IVTRTFSKIYGLAGLRVGYGIAKDEIIRTLFTVKEPFSANRVAISGATAALDDEEFIK
                     ETYELNRVGMAYFKEEFTKMGFDVVDSQSNFLYVDMKTDIPKLFEDLKKRGFVIRPSA
                     THARVSIGTMEENRKFVAVLKEILNIKGEPSIG"
     gene            complement(19944..21374)
                     /locus_tag="KNP36_001986"
     CDS             complement(19944..21374)
                     /locus_tag="KNP36_001986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0873859.1"
                     /translation="MSSQESKPKGNLISNFRDDMRDPKKRAIYTYSSSINLAYNFIGY
                     FVSTVTNIFLTDVAKLGVIMAGGMQIIQSFIKIAVAPITGTVFDKQPFKKGKYYPWLR
                     YAPAALALTYGIFFIVPLMKISPALLLPLMTALLLIASCAQQVVFTIIYAIYPVVAKT
                     PRDRVIGSTTTNIFKEVGKFLVGFSYPLLLVLFADVLGGEGMGYLGTYLFFAAGCLLV
                     FWFSSTEIIKSGAEEEVLQKEEKPKIKASEMAKALFTNVPLMMAFCLEFLICIRSIGL
                     GPLAPYYFKYVIEDERGLAVFLSIMPLVSVAFMFFAPVFIKICREQKLASIISFSICA
                     LCHLLVAWTPWGKTTLGVTMLLAIGGGFSNVVSIINLNFFAGSCDYGHWKSGKDLPGL
                     SMSLYPVAIQVGVLLATTIRTVLMNSMGYQADMVVTEAVKSGFINMISYSMAIPLIIA
                     VVIAILYPVSDKKLNQIREELNQRNA"
     gene            22032..23396
                     /locus_tag="KNP36_001987"
     CDS             22032..23396
                     /locus_tag="KNP36_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter family protein"
                     /protein_id="HBF0873860.1"
                     /translation="MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATI
                     AATSFGGGCLVGGVQWGAERGLWVGMYSTIGAALACFINAFFAGKLRSLSCDITPADY
                     IETRYGHSVFLRAYQSLVTPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIII
                     YTYTSGMWGVAVSAFIQLAICIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKS
                     ISDFMYTVLPLVLGSIFSYESFLRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAI
                     GGSLFPNISSVQVLPQMISTTLPPLISVLFLAAILAAIMSTADSLMTSMSAIISRDIY
                     NKLLHPNIEFNDLKNTLKYSQIASALTAIIGAIIALKFDSLLELLFWPAPLCTGVIFA
                     PFVIGLCWKGATKKGAIYAVIVSVILALLNMIGILTVFDRILVPIIGGSITIFIVSKF
                     SKKD"
     gene            23420..24073
                     /locus_tag="KNP36_001988"
     CDS             23420..24073
                     /locus_tag="KNP36_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0873861.1"
                     /translation="MSKSEKGKETKASIISAARELFFEQGYHKTTTRQIAERANINLG
                     LISYYFSSKSEIGAIIYEDIRNEMQSLIYNYHEEGTMMMFFLAMNADLCFLLKNEAYR
                     NFYLDIAYEEAILSYQRSVTEMVMKRYVNDKESIEHDELILSCIGILAMKPEIIRVYT
                     SHKYDISSQAVIKHFTKQFLINLGHSTDLCEEILEELSKYYIDIVDNFTPIITRVRT"
     gene            complement(24192..24974)
                     /locus_tag="KNP36_001989"
     CDS             complement(24192..24974)
                     /locus_tag="KNP36_001989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HBF0873862.1"
                     /translation="MAFIECKFKSKYTGGETDIIVILPVANGKELFSGKEIYDFEGKF
                     KTLYLFHGLEDDQSSWIRYTNVEHYAKNKNIALVIPRVETSFYTDMAYGHQYFTFVSE
                     ELPKFVRAIFPLSDKREDNFVAGMSMGGYGALKLALSKPKEFSAVASFSGSPDMIHEL
                     ENQQIETNADILFHDFGRPEDARNSENDLLYILKNLKERNEDIPKIYQFCGDRDFLYK
                     NNQMFKKYADSLGVDVEYEECVGGHEWRLWNLWIKKFIDIIG"
     gene            complement(25091..26257)
                     /locus_tag="KNP36_001990"
     CDS             complement(25091..26257)
                     /locus_tag="KNP36_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBF0873863.1"
                     /translation="MKINWNTKYTTIAIYTFIIAASSIIFYLVSSQIDVFSNNLDAIF
                     TTLQPFIIGFAIAYLLNFILKFYEDRIFIKSEKLKKLKQSSKRGLGLLLTYATATLIL
                     YLFMHFVLPQVIESIVGLANDIPMYVNNATKLIDKLMTDLNLDEQYFNLAVDKWNEFV
                     TYIIKFVTDLIPILGSMLKNVASSIWNIVLGLIVSVYLLIDKEKFYGLSKKITYAVFT
                     EKQAARILELTHRSNYTFGRFLGGKILDSFIIGILTFVILTLVKMPYTLLISVIIGIT
                     NIIPFFGPLFGAIPSTLIVMFVSPIKAFWLLLIILIIQQIDGNIIGPKILGDSIGISA
                     FWILFSLLVAGKLLGFIGMVIGVPMFAVIYSIIKDIVESKLDKKGLPTDTSDYM"
     gene            complement(26396..27760)
                     /locus_tag="KNP36_001991"
     CDS             complement(26396..27760)
                     /locus_tag="KNP36_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase"
                     /protein_id="HBF0873864.1"
                     /translation="MDIKELVKMQRKYYNTGKTRDISFRIEQLKKLKLVVSQNEEKIL
                     LALKKDLNKSDFEGFMTEVGMFYSELNFAIKNIRKWSKIKRVKSSMVNFPSISKVVPQ
                     PYGVTLIMSPWNYPFQLALIPLVWSLAAGNCVILKPSEYSVSTSSVVKDIVEDTFSKE
                     YVAVVQGSQEESEKLLLERFDYIFFTGSTNVGKIIMKSASEHLTPITLELGGKSPCII
                     LKDANIDLTAKRLTWGKLINAGQTCVAPDYVLVHEDRKNELIEKIKYYTNKYFGDNAC
                     NNEQFPKIINQRHFNRILSLIDKDKIVYGGNYNKETLKIEPTIVDNVNWDDNIMKEEI
                     FGPIFPILTYKDLDEVIQKIIQMPNPLALYIFTKNKYLENKLLEMIPAGGCCINDTVT
                     HIATNYLPFGGIGESGMGSYHGKAGFDTFTHYKSVLKKLNLDVPIRYAPYDNKLIKVL
                     KKIM"
     gene            complement(28072..28596)
                     /locus_tag="KNP36_001992"
     CDS             complement(28072..28596)
                     /locus_tag="KNP36_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBF0873865.1"
                     /translation="MKNVVVIYKSKYGSTKKYAKWLSELLSCDIFETKNINIEKVMKY
                     DTIILGGGLYACNIAGISFLKKNYKELQKKNLVVFGVGAAPYDDEVIKKLREVNFKDE
                     LNKIPCFYCRGAWDETKMSFIDYTLCSFFKKSIAKKERQGLKPAEAPLLSGEAFDWCN
                     KENLTPILDYIREL"
     gene            complement(28646..29143)
                     /locus_tag="KNP36_001993"
     CDS             complement(28646..29143)
                     /locus_tag="KNP36_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0873866.1"
                     /translation="MDAESLMKKYMVDDDSRKQAIFASIFVMQNKLQTTCDKLDPELT
                     MKQWLLLAIADSVDETLTLTKLGELMGCSRQNVKKLAIALEKKGFIQIEQNEKDSRAI
                     CLVTKDRVQEYSKKVRGMQEKVLQLLFEDFTEKEVEQLFFGIMKLSIGIENVKNYVEN
                     NDVGE"
BASE COUNT         9571 a         4997 c         3184 g        11499 t
ORIGIN      
        1 ttcatttatt gatgtatgtt caatttttat atttatattt ttcatatctt cataaataat
       61 tccaactgga gaacaaatga aacaagaaaa tccaaaagtt tttgttattt tttttacctt
      121 attatcacca aaacttattt gctttttaca atcgtttata ttttcattgt tattttgtat
      181 atcattttta taatacttat cttttttaat gtcattagac ttatttactg ttttaaaatt
      241 actcctattt ttacaactat agtctatttc aacttctata tacccaaaaa ctatcaagtt
      301 acataatttc aaattactac ctttgtttat aagatttttc ataggtttaa catcaaatat
      361 tttactattt acatttactt ttaatatatc tcttagattt ttaggagctt ttaaagtatt
      421 acttatattc aattgtttga atacaatttt atttacatta gtataaactc tattactttc
      481 tattgatatt cttgttggga atttatctag attacactta taataatagt atatattagc
      541 actattcttt ataatcctat gtgcagaatt tggtaaaact acactcttaa aagatattat
      601 ttttttacaa cttgcatcta ttctccctat gtaaaaacct tgctgtgggt ctaatccacg
      661 ttttataatg ccattaactt ttaccgtatt atttataaac tctatatatt tagaaatata
      721 atctttgaaa aatatatttc cagttttgta cctacttgta tttgtaacaa taatagtgta
      781 ggtcaaaatc tcaaatacag atgcacattt tttatcaaca tatttttcta cttttataat
      841 acttccattt gcatcatttg aaaatacatc attaaaagta gttttcgtta ttctcattgc
      901 atccaccttt ctataattta aagattactc tatcttggaa ctattttcat aacttataat
      961 tgcagtaaca ctaataaata aattatcatc taaaatagat gaagtaatat cttgtataag
     1021 atactttaaa ttaattttat ctttattttc tatctttcta ggcatttgta taaatgtact
     1081 aaagggtatt tttaatttaa atgtattttt tttactagaa tttctatttc ttttattgcc
     1141 tgcataatct aatattgcat caatatctat atcaccaact aaaatcaact tctttcctgt
     1201 aagttgttca tcttctaatg atatacattc tatagtatca acaagactta tattgttaat
     1261 attcatattg taaacatatg tctctaatga atttattaca gtttttttag aagctaattt
     1321 aaaattttta tatgtattaa attgagataa ataaagagtc ttttctagtt tttcacatct
     1381 ttcaaggttg tatattacct tattattttc atacataatc gcatcaatct ccctgtatct
     1441 atatattaat actattcata aaaattattt caaattacca ttttttatta ttcactatct
     1501 agttgttatt tacttttaag aaagaatcct tttttacttc attgatttca atttacaagt
     1561 aaaagtcttt ctgaaaaaaa aatatatata tctctattca cttttttata agtaattata
     1621 atttttatag actaacggtc agccttaagg gaaaaggtgt tctttaagtg cagaatttag
     1681 ataaagtaaa taatcctttt ataaataatt ccaagtttta acttaaataa tttgatttac
     1741 agtataaagt aaattttgaa agataatgat atcgatttaa taattacaag taaaagcatg
     1801 tcaaaataag gctatgattt taaaaatcat agccttatca ataaaaattt aatcaaagtt
     1861 acatttcact ttgaatttca ctgtctatta attgaagatt atactgttga attaattcta
     1921 ttagacgagc tgcatatata ctattgccat tttcatcctt cgcagtacta taacctgcct
     1981 tttctaatgc tttagcttga tatatatacg tttttgcatc aaatacacca ttgtttttat
     2041 accttttatt tgtggctaaa aattttgcat ggtcttttat agattcattt ttatcatcat
     2101 atattctaaa tttatcatct ataattgtat ctaaatgttc tttcgtttct aaagtcactg
     2161 acttgccttt ccaataagcg tcagccttta taccaaatag attgttatat tgttttgcca
     2221 aagttgactt gccccagcta gattctatta tagcttgtgc aatagttata gatggaagta
     2281 ttttataatc cttataattt tgtattgctt ctgttttaat ttcatcaata aacttcatat
     2341 attttgtatc agacttcaat ctttctggtt ttataccata atccttaaga ttgtctatat
     2401 aattatcaac caatcttttt tgtctattac taaattctaa ctcatccaaa atatcactta
     2461 acttatttat tttattattt ttagaaaaat tcttaacaaa taaatctgat acttcttgta
     2521 tctgtgaatc cttaacgttt tttaagttat ttttatttaa cacagcaaca atggaagcta
     2581 catacttcca gttaacttgt gcattatttt tacttgctaa atcagcatat tttatatact
     2641 tactgacatt tatatcatcc ttttttatct ctctagatga atattccttc actaatacac
     2701 ctattaaaat tgatattatc agtattataa caatgaattt tttattcttc ataaatattg
     2761 tcctccctta tactatctgc tgaatataat ataccttact tttgtgacat attctttacg
     2821 aaattttgaa aattttatga agatttatga aatatattta attaaaagca ctactattgt
     2881 tataatatat agttttctat cacacaaaat agttaaaata aataaataat tagatagctt
     2941 attttaacta tttatataat aaaaatatta ttaaatctat ttatcaattt ttatacattt
     3001 ttctaatata tattttttcc catatacaat aatttttatt ggtttacctt ttaaattttc
     3061 tattttaatt aaatcactac atacatctac attaataata ttatctctat aatttatatt
     3121 gaaagaataa tttttccact cttttggcaa cttagggtca aaagatagag tttcattcca
     3181 tgttctcatg cctgcaaatc catgtacaat ggaaagccat gaaccagaca ttgaagttat
     3241 gtgcagtcca tcatttgtat cattattgta attatctaaa tcaagcctag ctgttcttga
     3301 atataattca taagcctttt ctaggttatc tatttctgag gcaataatag aataaatact
     3361 agaagataaa gaagattcat gtacagtata tttttcatag aagtcaaaat ttctcttttt
     3421 ttcttcttta gtaaatctat ttccaaaata gtaaattccc tgtaatacat ctgcttgttt
     3481 tataaaacac gacctaagaa tcttatccca agaccaattt tgattaagag gaaaattttc
     3541 ttttggtaaa tcctttactt ctacaaattc tttatctaaa aaattatcat tttgaattat
     3601 tatttgtagt tcctcatcat acagcagata cattttattt gatattattt tccaaaactc
     3661 aacttcttcc ctagtcacat tatttctgtc aatacattca ttacactctt tctctaatcg
     3721 taagatattt tctacagcat aatctaaaca ccatttagct atataattag tataccaatt
     3781 attattgata ttgttttcat actcgtttgg acctgttact ccatgtatca tatacaaatc
     3841 tttttttgta gacaaatgaa ctctacttgc ccaaaatcta gctatttcta ttattacatc
     3901 tattcctttt tcttttatat atttatagtc acctgtataa tttgtatagt tatatattgc
     3961 atatactata cttccatttc ggtggatttc ctcaaatgtt atctcccatt cattatgaca
     4021 ttctactcca tcaaatgtta ccattggata taaagcacct ttaagaccta gtttttttgc
     4081 attatccttt gcctgttcta actgattgta cctatattct aaaagatttc tagttacctc
     4141 cttatctgct acacctagat atactggaac acaaaacgct tctgtatccc aataagtagc
     4201 tcctccatac ttttcaccag taaatccttt tggacctata tttaatcgcg aatcttctcc
     4261 ataatatgtt gaaaatagtt ggaataaatt atatcttata ccttgttggc tacttttatc
     4321 tccatttatt tttacatctg cactttccca tcttttattc cataacttta tatgttcatt
     4381 taatatatca tcataacttt tagatagttc tctatttaaa atgtcttcac attttcttaa
     4441 tagctcactt tccttataat ctctagttga ggttatagat acatattttt ctatacttgc
     4501 aacctcattt tttaaaacat ccattgttat cgaattttca cagtaattat aatcactctc
     4561 atgagataca gcttctacat caccatttgt cttaatatac atcattgaac ccacagtgaa
     4621 tactggtgta ttaaatgcat tctcctttgt tcgagaaaga atactccctt tatattctaa
     4681 agaacttgaa gaaattccat tccaaaactt ttcctcatag tttgaatctt cattttttat
     4741 atttgaatct aaatatggta caaattttat tttagtatta gaatttaatg attttatact
     4801 gtatttaatt actgcaagtt ccttaacaga tatacttaaa aacctagtaa ccctaacttc
     4861 aaatttttta tcatttatat ttacaataaa cctacgattt aaaataccat ttttcatatc
     4921 taattctcta tgaaaatctt ctactttaca ttttgctaaa tctaattcta catcatctat
     4981 gaaaattctt acacctatat agttgactga attaggaatt ttaccaaagt attctggata
     5041 cccatttttc caccaaccaa cacgagtttt atctggaaac catactccag ctatataaga
     5101 ccccttgtgt gtatctccac tataattttc ctcatagttt cctctcatac ccatatatcc
     5161 attgcctata ctcattatgg actctgctaa tctattttct ttgatttcaa tcttatcttg
     5221 tataatcttc cactcatcta cattactaaa taaacatttc atataattct cctaactata
     5281 tactcattat acttttcttg tatatattca aactttaatt gatttgttga atctacaact
     5341 aaatttgctt tttttaagtt ttcataattt ccaacaccaa cagaaaacat attagctgag
     5401 tttatagcgt ctatacctgc acttgcatcc tctatcccta tgcaattttg tggatttaca
     5461 ttaagccctt tcgctgacat aagaaatatc tctggatgtg gtttattgtt tttacatttt
     5521 cctgcatcag ctataaaatc aaatttgtca cttataccca aatgatttaa tacatttatt
     5581 gcattcttac ttgcagaaga tagacctatc tttatattat tagattttac atcaattaac
     5641 aagctttcta tgcctggcaa aatatcattt gaagttatct catctatcaa tgatacatag
     5701 taattatttt tttcttcagc cattctcact ttttcttctt ctgaaaatga atatttctta
     5761 tttccaaatt ctaatatcct gtccaatgac tccattctac ttatgccttt taaagattca
     5821 ttaaattttg tgtctatatc tatcccaact ttatgagcta gttttctcca agccatatag
     5881 tgataatatg cagtatctgt aattacacca tctaaatcaa atataaatgc ttcaatcatt
     5941 cttatttcct ctttctacaa gaaattttta gactaataat caatttattt tctatcttgt
     6001 atttaagata ttatttataa aattatctac tctaactcag tctttaattt aaaatctact
     6061 ttcaattcac tcacttgtag accatatttt ttatcgttta taaagacttg tttaaactgt
     6121 ataataattt aacatgaaat ctaaaataaa tacttttttg tattatttta aaataatgaa
     6181 cttgtatttc tctaacatta gttcttcttt taaatcaact atttcttctt catataaatc
     6241 ttttactttt ttatttgcta aataatctgg taacgtcaaa attatatttt tagatgaatt
     6301 atttattatt atagaaatag attctttttt caatataatc gttccatttt ccttatctgc
     6361 taacacccat tcatttgata tagacctaag ttctttattt tctttacgaa gtctaataat
     6421 cttcttcata aaatcaaata tatccttatt ccatttttct tcattccatt ccatacattt
     6481 tctttgacct tcagatattg aacttaattc tccttccatt ccgatttcat caccatagta
     6541 tatacaagga catcctgttt gtacaaacat aaacatatat gcaagtttaa atctatcaat
     6601 atttccatta gcataagtca atattcttgt agtatcgtga cttccaagta aattaaaaat
     6661 aacttcacta acttgtattg gataacttac cattacatca tttatcatat acttaaattc
     6721 ttcggcgttt atctcatctg tacaaaagaa ttttttcatg gcttctgaca tcaagtaatt
     6781 cataactgaa tcaaattggt cacccattaa ccatggtaaa ctaccatgcc aaatttctcc
     6841 caatatataa atgtctggtt ttactttttt gacttcttct ctaaactttc tccaaaaaac
     6901 atggtctact tcatttgaaa catctaatct ccacgcatct atatcaaatt cctgtatcca
     6961 gtacttgcct acatccaata aatattttat tacttctgaa ttttctgtat taagtttagg
     7021 catatatttt tcacacccaa aggtttcata aggtatattt ttttcatcta tttgttctat
     7081 tggagtatca attttactca tatcttttat ataaaaccag tttttatatc gagaattttc
     7141 cttattttga actacatctt gccactgttt agaataatat cctatatgat taaaaacagc
     7201 atccaacatt atttttatat ttctcttatg cgcttcttct attagttttt ttaaagtctc
     7261 tttatctcct aatgtagggt ctacctccat ataatctacc gtatcatatc tatgattggt
     7321 ttttccaatt gtaatagggc aaaagtaaat tccgtttatt cccaaatcac tcaaataatc
     7381 taagtgttct atcacacctt gtaaatctcc acctgtaaaa ttatctctgg ttggaatagc
     7441 tccccattta tctactcctt ctgggtttat agacgggtca ccatttgcaa atctatctgg
     7501 aaatatctga taccaaacag tatctttcac ccaatttggc actttaggta tatctatata
     7561 atttaaatat ggatatccaa aaaaattacc tatttcacat aattcctttt catcattttc
     7621 atttcccaac tctattattc ttttttctgt aaataaaagt ttttcctctt gaccttctat
     7681 tataaagcca tatcgtgagc gtttatttaa aggcttacac ttagctatcc aatagtcaaa
     7741 taattcagtt tctacttctt tactcattac tatatttgtt ccaccagacc aaccaactcc
     7801 agatgcattt aaatttcctc ctcctgcacc tcctttatcc cacacatatt ggtctcctat
     7861 tcgtaaaatt actcttttcg cttcattttt tttagttcta agtcttatat gtagtgtttc
     7921 tctatcataa ccataggcat aattgctcat tggtatatgt aatatagctt cttttgttaa
     7981 actattttga attgttcctt tgatttgatt acttaaagtt atattttctt tatttttatt
     8041 agacatttta aaatttccct cctttataat aatttatata atctaaagat aggttaatat
     8101 attttactat tatatcacaa taaaaatata taatagtaaa atatatcaac aataaactat
     8161 tcaatttaaa ataagctata ctatttaaat ttaattctat ttagttattt tagcaaaata
     8221 aaaacctcta gtatttttct agaggataca atactataac tattaacttt ttaactatct
     8281 attaatttac ttcaaaacac actctaagct atattgttag atttaacttt ttctatattt
     8341 acaaaatagg tttctctttc tttaaataaa gatacatatt taaagtcaag atacttaagc
     8401 atatcatagg ccacatcaaa atctttgcat atatcttcta ccctatgaga atcagaacct
     8461 acagtaacta taaatcctcc aagttcttta tatcttttta gaatatcttc atttggatgt
     8521 atagcattta gtccatatct ataaccagaa gtatttagct ctataccact cccattattg
     8581 attattgact ttaagacctc atcaataaca tctttaaagt cattgtatat aactctatta
     8641 tctgaatata ttccatacct agatatataa tccaaatgac catatatatt gtaatctcca
     8701 aattcacgat tagtttcaag tatgctatta aaatatttat aatacgcatc ttctttgcta
     8761 agacctttaa aatacgcctt tgatggaaca ggtacattgt caattgtatg agttgagcac
     8821 aatacaaaat caaaaggatt agaatttatt atttcttcta tttcattttt tagatgtttt
     8881 ctgtaaccca cttcaacacc tagtaataac tctatgtcct ttttatattt ttctttaaac
     8941 ttattaaata ctggaacata gtcattataa tttatgcaaa atcctctatc ttcatcatgt
     9001 tctaaatggt ctgtaaaagt caaatatcta acaccaatac ttatagcttt ttttattgta
     9061 tcttccatgg aatcctttcc atcacttgaa aaattagtat gaatatgatt atctattaaa
     9121 ttcatattat ccctcccttt attttatcta tcttaattat acaacaagtt tattgtatac
     9181 atttgttaaa agaaaattat aatggttaaa ttttatttac atacttttat ttttacaaaa
     9241 aagagaagca cctatttctg attttagaaa atcattaagg atacttctcc taatgttact
     9301 tttatatact tcaatttaat ttttaaaagt cttaattttg taatagagtt tagctgttat
     9361 atgtccaatc atataaaaag ctgtataaag taaaacatat atatatgcag aatcatttaa
     9421 aaatatatac attaatacta tataagttac taaagaaaca ataagagata aaatccaatt
     9481 agtcttattt aatacacaaa ttatcccttg tatcaaaaaa gaaattggaa aaatcaaaac
     9541 cattcccaca acaaaaatac ttttagattg aatatctgga atattaaata tatctgtagc
     9601 aaaagttaaa aacattagca ccattatgac tgtaggaaat atgatactaa aaatattact
     9661 ctttttcata ataatcaatc cttatttatt ggatatttga taatcttcaa ttattttgtt
     9721 gcctcaattt ctcccatcat tcttactaaa tcttgtccat attgacctcc agcccaatta
     9781 ttagataaac tttcaactgt tttagcctta ccaaataaag atttttcatg tctagggtct
     9841 actggatttg aaagtgggta accatcttgt cctgcatata agcataaatg ttgaatttga
     9901 gctaatattc cttcttccca agtatcaaat cttgaatggg cattcttatc agtatcagaa
     9961 ccacctacag aagttttaag tccacaagga ttcttaaatg atgcatctaa tactccacca
    10021 aaattacaaa aaccagtttc ttttgcagat tgagctactg ccaaaacagg attaacacct
    10081 tcctgaacag cagtatcata taatattggt attaactcta taaataaatc attagctttt
    10141 ttagattttg cccattttaa gcacgcttct aaactagctg ttggctgacc taatatgctt
    10201 gtctcatttt tcataggtga ctcacctttt gtagacgaat cgccattatt ttgtgcagca
    10261 gaaacacact tattatacac actgtcactt attgaaccta atctagtaat cttatctgct
    10321 cctgctaata tagacttatc actactttct gacaccaata caattggatt ttccttagca
    10381 attgtagaac ctgtaagtgc atttactaaa tcatatccat cactcaaata aaattctgat
    10441 gcatctggat aaaactcttt tataactttc ttatttgtat catatctatc tgaaccacca
    10501 agtcttttag cattagtttt attaactaaa ctagtgctca ttgatatact cccacctact
    10561 gcatatgttt ttacattgct tgttgaaaaa ggcacactct ttccatctgt aagtactata
    10621 ggagctatat ctcttactga tacgggtgca gcacttattg tatctgcttc tcctttatat
    10681 gcattagtta atatcacttc atcaactttt ttgataccat ttacctcttt agcaacacta
    10741 taactagtct ttattctgtc atctccaccc aatctagtta cctgtgcccc tgtgtttttt
    10801 agttcagttt ctactgactt acttattgat aattctttac ctattatgta tatcttttta
    10861 acatttttta atctttgttt tgtttcattt ggtatcttat ttttttgtgc aagcaaaatt
    10921 ggagcatcaa cagcacctgc aagaccactt gctgaaagac catctgctat agaattatcc
    10981 atatttacca taattgctgt atcataactc tttttatctg ctattaatcc agccgtctca
    11041 tatatattgt tacctttaat tgtatctgat gttaatgcat ctacattagg tacatttatt
    11101 agaaatatag ctaatgttaa acctaatgct aaaactcttc taattgttct catattcttc
    11161 ccccttgata tatcaagttt aattcaaaaa tgactataac atagtattac atctacgcta
    11221 tagtcattta ttataattta ataattatat atttgttatt atatcataaa ttacaaaaag
    11281 tttccataat attgtataga ttaaaggaaa aatttacatt ttagttacaa tttactagat
    11341 ttttgttcta atgtacctat atttagtaac aatttgtaat aaaaatcgat atctatatta
    11401 catatttaat tcactgtttt acaaaatgaa attttattgt atacaataaa tagattatat
    11461 gtttacataa tctatattat ttttaagtaa atcttttatc gatattatta agaatatata
    11521 ttacatcaag tttattacgt gcaaaccact atcaacttaa atacctaagg taacacttga
    11581 agtagtagat tcttggtaac aataattatt gctatcatta tcttttttta attaagtatt
    11641 tactatttat atatcaatct acttttcact tttaatttaa ttctaatatt tttttatatg
    11701 ttttatgata tataatgtga tatattctaa ttaatgatat tttcaagtaa aaaaatgtta
    11761 ctctattata aggtgatagt atacttgaaa ataaataaaa cacttaactt tatttaagga
    11821 gatttatgat gagtaacaaa caaggttcta acatcaaaga tgtaaaaatt aaaaataagt
    11881 taataatatt gaaattactt tctacaaata cacctatgtc cagagttgat ttagctaagt
    11941 ctacaggact tactaaaatg actttatcaa atctagttac tgaacttatt aatgaaaata
    12001 tgattaggga aatagagtca tcaactttaa atgcacattc atcaggtcgt aaacctattt
    12061 tattagatat ttctaatata tcgccttgta tttgtggaat cctaataaga agaaatatat
    12121 gtaaggtaat tatttcagat ttaaaaggta atattgtaaa acaactttct gaaacttacc
    12181 ctaaatttct atcaaatgat gttttaaaag atataataaa aagaatgttt actaaaataa
    12241 tgaaaatcaa caagagagat ataattggaa ttggtatttc ttcaataggt ccagtagatg
    12301 atataaatgg taccatacta aatcccccag attttggaaa tgtatcaaac ctaaatatag
    12361 tagattttat aaaagaaatg tctgatttgc caatattttt gataaatgat gctaattcgg
    12421 gtgcattagc agaaaaaatg tatggtttag gtaaaaatat atcaaattat atatacctac
    12481 acataatgaa tggtattgga gctggtctag ttctagaaaa taaacttcat actggcaacc
    12541 taggacaaag tggagaaata ggacatacat caattaattt tagtggacca ttgtgcagtt
    12601 gtggtaacaa tggatgttta gattattata caagtgtcag taatctaatt aaaagaattg
    12661 aatcattgag ccatatttat cctaactccc cattaattaa ctgtaaagat ttttctttag
    12721 tcaagttaat agatgaggca aataataaag atagtcttgc catgtttttg cttgatgaat
    12781 tttgtacata cgtatcatat gcattagtta atacacttac attgattgat tgtagttcta
    12841 taataatagg ctatgacttt aatatacctg gtacatttat agaaaataca ttattaaaaa
    12901 aattgactgc ttcagcaagt ttttctaaat ataaaaaaat aagtgtaagg cattcaaatt
    12961 ttggagcaaa tgcaccatta attggctcta tagccattgt aagttataat ttttttaatg
    13021 gtagtataaa tttttattaa atatgtaaaa tatttaaaca cttttattga atatttttcc
    13081 atttaatatt attatatttt ataagagcat ttaaaatttg gaggtataaa aatgatttca
    13141 gctaaaatgg aaaaattact taatgagcag attaaccatg aattatattc tgcgtatctt
    13201 tatctttcta tgtcttctta ccttgaagca gaaggactta aaggattttc taattggttt
    13261 tatgttcaat ataaagaaga gacagaccac gctatgtttt tttacaaata cttacataat
    13321 gtaggaggaa aggttcagct tgatgctatc ccaatgccag attcagactt tacttctgca
    13381 atggatattc ttgagcgtac gttagctcat gaaaaaaagg ttacagcttt aataaacaac
    13441 ttagcagctg tagcaaactc tgaatcagac tttagaactt ctcaattctt actttggttt
    13501 atatctgaac aagcagaaga agaaacaaat tgtgaagaca atataaaacg tgttaaactt
    13561 gctggagagg gtgggctatt ctttgttgac caagaatttg ctaatcgtac atatgcagct
    13621 ccaacaaacc cacctgtgac aatataacgt ttaaaaattt ttaatataat aaagaaggtg
    13681 ttttaatgaa aatcaagatt gattcttatc attaaaacac cttttattat tcgttttata
    13741 cgtagtattt tattgtttat acagtgctat ttcacaatga aacttaaaac tatactttca
    13801 ttttaaaata tttttaaatt aaatttgggg tgactgaaaa tcacactatc taacttacaa
    13861 aatgtgattt tcagttggtg ctttaattat ggttgaatac caaaacttat aaactattta
    13921 tatttaacta ttaaggcatc tactgcacat acgccttttc ctttaggata tacaaacact
    13981 ggatttaagt ctatttcctt gacttcatcc ttattttcat aagcatattt tcctaacttg
    14041 accatcatat ctgcaagagc atcaatatca catggctcac ttcctctata gccatttaaa
    14101 agcttaaatg attttagttt tttaagcatc ataatagctt catcatgatt tataggtaat
    14161 ggatataatg tagtatcttt aaatacctct acaaatactc ctcctaaacc gactaataac
    14221 attggtccaa attggtcatc attagttata ccaataataa tttctatacc actttctacc
    14281 atttcttgaa ctaatatacc atcaatatta gcatctggtt ttgctttttt tacattagtt
    14341 aaaatctcat tatatgcatc tactgcctca tctctattct taattcctat tttaactcct
    14401 ccaacatcag atttgtgcaa tatttcagaa gaatttattt ttaaaacaac aggatactta
    14461 atatatttta agatttcatc taattcatca atactttttg cattaccttg tcctggaact
    14521 ggtactccat attttttcat ctcaatctta ctatctaatt ctgataatgc tactacatta
    14581 tttgactctc ttttcttaac agctttaaat tctaaagttc tttttgaata atcataatct
    14641 ataaacttag ccattttatt aaaacaagta aatgtagttc caactgatga cattataggc
    14701 acttgattat cttctaatct agtcctataa tctaaatatc tatttccttc aagtgtagga
    14761 actgcaaaca caggtttttt caatccttgt tctctagctt cacttacagc tttacaaagg
    14821 gtttcatgca tttcattttc ttcatctctt atatttgcac ctaccatagt aaatccaaca
    14881 ctatcatcct tttcaaaggt atgtaataaa cctactatca tatccttttc atggaataat
    14941 gctgttgtag catctagtgg atttttaggt gttgcaaatc ctggaagata tttttccatt
    15001 tcttctttag tttcagaaga tatttctgca agttctacac cattttcttc tgctaaatct
    15061 gcacaaatag tattttctcc tcctgagaag tttattgctg caaaattaga atttgcaggt
    15121 aaattaccat ctaaaacact aaaagcttgt gctaaacaca taaactgttc taaattttcc
    15181 acagaaatta ctccatattt ttcaaaaata ctttcaaaag ctttactcga accagctaaa
    15241 tttcctgtat gagaagcagc agaaatagca cctttttctg accttcctga tttcaatatt
    15301 attactggct ttcttttttg tgctgccctt tttaaagcat ctataaattt ttgaggattt
    15361 tttaaacctt caaggtaaat tgctattact gatgcataat catcatctac aaggaaatct
    15421 actgcatctt ctagtgtaac tatatttcca tttcctgttg aaaaaccata agatatatta
    15481 aaataatcac ttgaaacaat ttcagcagtt ataaatccac tttgacctac aattcctata
    15541 ccaggttttt tagtatctaa atcccattta gaacctcctg cccatagatt aaccttatct
    15601 atacaattta gcaaccccat gcagtttgga cccaatattt tcatatcgta tgtatttgat
    15661 atttctataa gttgattttc taaatctgta ccttcctctg taccttcctc tgcaaatcca
    15721 ctagcatata ccactgctgc ctttgttcct aactctccag aatcttttaa tacagatgga
    15781 actacatttc taggcgtaca tactactaca cagtctacta cttctggaac ttcttgtatc
    15841 gtcttataac attttctccc aaacaattct tctcttttgg gattaacata atatactcta
    15901 tctgtttcct tactttttac tatactaagt gctgcacttc ttccaaaacc aagtttatca
    15961 gtcactccta ctatagcaat actttttggt ctaataagtt tttccaaact cataaattca
    16021 cgctcctata tgtttatagt tgtgatttta agtgaatttt atctcaagat gaagtttctc
    16081 ttggcactaa agattattaa atcttgagat aaatcactta agataagggt aatttatcaa
    16141 atggcgttat tatagccttc catgaatgct gcttcatttt gaacattaaa ctttcctttt
    16201 cctttttcct caaagaaatc acacatagtt tttaaagcta attctttttc aaataaccca
    16261 gttttagcaa ttaatgctcc aagtactact atatttgctg cttttggatt gtttactttt
    16321 tgagctaatt cctgacaatt tattttaact acacttatat cttctcttaa tgttacattc
    16381 tcatctattg cagatgtatt aataactact gttccacctt ctttaactaa atttatataa
    16441 tctaaagatg gtttattcat tgctactaaa acatctattt cttccatatc aggcccacct
    16501 atactctcat cagaaaactt tactacacta taggcttttc cacctctcat agttggacca
    16561 tatgcaggca tccaagttac ttgtttcccc aattcaagtg ctgactcagc tacaatcaga
    16621 ccaagagtta aaactccttg accaccaaac cctgcaaata ctagctcttt ttccataact
    16681 attcaccatc cctttgctta aattcgccaa gagcataata tggcactatt tcttcttcca
    16741 tccatttgat agatttctct agtgatacac cccagttagt tgggcaaggt gctaatattt
    16801 caactaagga atatccctct ccatttaatt gagcttctat tgcatttttt atatattttt
    16861 ttagattaat tatttccttt gggctatgaa ctgaacctct tgctacatat gctacatcaa
    16921 agaagtttgc caccatctca ggaactttca gtggactacc agtagtcttt atatctcttc
    16981 catttacact tgttgttgtg acttgacccg gcatagtggt ccatgacatt tgtccaccag
    17041 tcattgcaaa attattattg tttattacaa atacagtcac attatgattt ctatatgctg
    17101 tatttaaagt ttcagaaaga cctataacat aagcatctcc atcaccttgg taagtcatta
    17161 ctaatgtatc tggaagtgct actttaactc ctatagctgt agatgaagct ctaccatgtg
    17221 cagtttgcat cttatcacca ttccagctaa aattcatatt gcagacacaa ccaactccta
    17281 atgttaatac atgatttttt tcatatccat gttcttctat tacctctgct attatacgat
    17341 ttactattcc atgaccacaa cctgggcaaa acttgtttgg tattgaaaca acgctaggtg
    17401 ttaatttttc tgtagccata ttagaacacc tccttgattt cgccagattt tattttgcta
    17461 taagtgtcca ttacttgcaa tgtttttggt atatgatttc cactaaataa accatacaca
    17521 ggtacatttt ctttacatac tttctttgag gctaaagcaa catcttctac taattgacct
    17581 gtgtctgttg attctactga gataaatcct tttacatctt tacttacctt ttcaaatgct
    17641 ttatatggga aaggccatac tgttattggt cttattattc caactttttc accttgttct
    17701 ctaagtcttc taacagcatt catagttgtt cttgatggta taccaaacgc tacaaacaca
    17761 tattctgcat cttctacttg ataatcttcc cattgttgtt cattttcagt tattctcata
    17821 cgtttctcca tacaaaaagt tggcttttgg ttatctgcaa cctttgcatg gtctctatta
    17881 cttccatcat aagtccaacc taaatctcct tctctcttct taaactctgg aaattctact
    17941 ggttccatca tttgacctaa agctgcttct gtcaaaattt cgacaggcac tctgtacttc
    18001 tccgctacat caaatgagtt atacatcaaa tctacagtct cttgaatact gtttggtgca
    18061 taaactatca aatgataatc tccatttcct ccccctctag tatctcttag atagtctgtc
    18121 tgtgctgagt ccaatgagcc aagaccaggc ccccatctct gtacatttac gattacacaa
    18181 gggtaatgat ttgcacataa gtaagaaatc ccttcttgtt ttaaagatat tcctggtcct
    18241 gaagaactcg tcatagacct cattccactt gcatatgctc catataccat atatatagca
    18301 gccatctcat tttcggactg tataaaagtt cttccaagtt cagacattct atgtgataaa
    18361 aattccatta cctctgtttg tggtgtaatt ggatatcctg cataaaattc acaacctcct
    18421 cttagggctg cttctgcaat ggcgtggttc cccttccaca tctttttcat attatcccaa
    18481 ctccttctaa gcctcttgac atgcttcttc tttaattatt tcaaaaacat tatctggaca
    18541 cacctgatag caaattccac aaagtatgca tttactctca tcaacttcta catgagcata
    18601 accttcttta tttatcttac ttgatatttt taatgctcct tttttacaag atataacgca
    18661 gtattcacaa cttttacatc tctctgcgtt tatttttaag ttcatatcta caccccgttt
    18721 cataatattt ctatctatta tccaatactt ggctctcctt taatatttaa tatttccttt
    18781 aaaactgcta caaatttcct attttcttcc atagttccaa tacttacacg tgcatgtgta
    18841 gcacttggtc ttattacaaa ccctcttttt ttcaagtctt caaataactt aggtatatct
    18901 gttttcatat ctacataaag gaaatttgat tgtgaatcta caacatcaaa tcccattttt
    18961 gtaaactctt ctttaaagta agccattcca actctattta attcatatgt ttcttttata
    19021 aactcttcat catcaagtgc tgctgttgct ccacttatag caacacgatt tgcagagaaa
    19081 ggctctttta ctgtaaataa agttcttatt atctcatctt tagcaatacc atatcctact
    19141 ctaagccctg caagaccata tattttagag aaagttcttg ttactataac gttataattt
    19201 tcccttacat acttaagtcc atccacataa ttaggaactg ttaaaaattc tatatatgct
    19261 tcatccaata tagttataat attttcaggg actttcttta aaaattcttc taactcttta
    19321 tcatccacaa ttgttcctgt tggattatta gggttacata cacatattaa ttttgtttta
    19381 tctgtaatct tatctaatat accttgtaaa tcatacttat aatcttctgt taaaggtact
    19441 tctactggta tcccttcatt ttttatagtt gcagttctat atgatggaaa tgttgggtta
    19501 caatatataa cttcatctcc tctatttata aaagcctcac ctattagagt gataacgtta
    19561 tctgcaccat tagcaacaat aaaattttct ggttttaaat ctagcttttc agctaatttt
    19621 cttctaagtt cgttagcttc tggctctgga taaagttgac cttgttttaa catttcaatc
    19681 atagcttcta ttgcttttgg tgatggtcct agaggatttt catttgaagc taattttatt
    19741 atttctttta caccatattt ttccttaact ttttctattg gttcacctgg aacatattga
    19801 tgtaattctt ttacggtatt tctcaataat ttttctatca tttttaaaag ccccctctgt
    19861 atatgtattt tcatttatat aaacgctatt gcgtctactt actttaatag cttaaattaa
    19921 ccatctactc aactttcttt taactaagca tttctttgat ttaactcttc tcttatttgg
    19981 tttaatttct tgtcacttac tggatatagt attgctataa caacagctat tattaaaggt
    20041 attgccatag aataagaaat catatttata aaacctgatt taactgcttc tgtgactacc
    20101 atatcagctt gatatcccat tgagttcatt aaaactgttc ttatagtagt tgcaagtaat
    20161 actcctactt gtattgcaac tggatatagt gacatactta agccaggtaa gtcttttcct
    20221 gatttccaat gcccataatc acaagaaccg gcaaagaaat taagatttat tattgatact
    20281 acatttgaaa aacctccacc aattgccaac aacatagtta ctcctaaagt agttttcccc
    20341 caaggagtcc atgcaaccaa taagtggcat agtgcacata tagaaaaaga aattattgaa
    20401 gctagttttt gctctctaca gatttttata aacactggtg cgaaaaacat gaatgctaca
    20461 cttaccaaag gcatgattga taaaaatact gctaatccac gttcatcttc tattacatat
    20521 ttaaaataat atggagccaa aggtcctaat cctatagatc ttatacatat aagaaattct
    20581 aaacaaaatg ccatcataag tggtacatta gtgaataaag cttttgccat ttcacttgct
    20641 ttaatctttg gcttctcttc tttttgaaga acttcttctt ctgctccaga ttttattatc
    20701 tctgttgaag aaaaccaaaa tactaaaagg catcctgctg caaagaataa gtaggtacct
    20761 aaataaccca ttccttctcc acctaataca tctgcaaata aaactaataa taacggatat
    20821 gaaaaaccta ctaagaattt accaacttct ttaaatatat tcgtagtagt tgagcctata
    20881 actcggtctc taggtgtctt agcaactaca gggtaaatag cataaattat agtgaaaact
    20941 acttgctgag cacaagatgc tattaataat aaagctgtca tcaaaggtaa aagtaatgct
    21001 ggacttattt tcattaatgg aactatgaaa aatattccat atgttaatgc taacgctgct
    21061 ggtgcatatc taagccatgg ataatacttt ccttttttga atggttgttt gtcaaatact
    21121 gtacctgtta taggagctac agcaattttt atgaaagatt gtataatttg cataccacct
    21181 gccataatta caccaagttt tgccacatca gttaaaaaaa tatttgtaac agttgataca
    21241 aagtaaccta taaaattgta cgctaaattt atagaacttg aatatgtgta tattgctctt
    21301 ttcttagggt ctctcatatc atctctaaaa tttgatataa gatttccttt tggtttgctt
    21361 tcttgactac tcacatctac ccctccctta taaaatttac ttacttttta ttattcacgt
    21421 ataataatat atattttgaa tcttaaatat ctcattcttg attcaggagt atatttttat
    21481 atgtgtataa ttttaattta attatattct caaaattcat aattgtcaaa cactttttaa
    21541 gttttatttt ttactactaa aattaactaa aaagctattt agacttaatt taggtttgtt
    21601 ttttattatt ttcttgtttt gaaatgtcat tgaaatgcgt attttaaatt attttatcat
    21661 atttctagtg attttaattt tttataattt tattcaagaa taatttattc aagatatttc
    21721 tatactacat ccagatatta aaaatatctt tttcttattt aaattccttt tatttttata
    21781 catgtactat tgatttaaaa ataaaagcgt gttacaatta caaaaaagaa tctatgagat
    21841 aaatatcaat atgcaaaaat ttcagaattt tcaattttct atttttacgt aatttccatc
    21901 taatatcata aattattata gctatattaa tctaaaacca ataaaacaaa tatcgtacta
    21961 cttttatata aaatatattt taaatatatt ttgtatattt tattaaaata ttttataaag
    22021 gagaaaagac tatgttactt ttaattgtta cgtgtgcaat atacatatgg attggttttt
    22081 atttttcaaa aaaagttaaa acagcatccg atttcctaat cgcaggtaga aatctgcctt
    22141 tgcctatact agctgcaacc attgctgcta catcttttgg aggagggtgc ttagttggtg
    22201 gagttcaatg gggagctgaa agaggacttt gggttggaat gtattctact ataggtgcag
    22261 ctttagcttg ctttataaat gcatttttcg caggaaaatt aagaagctta tcttgtgata
    22321 taacacctgc tgattatatt gaaactagat atggtcatag tgtattttta agagcttatc
    22381 aaagtcttgt aacaccaata tctatactag ctattatggg tagtcaattg atttcttttg
    22441 gttctgtatc tactgcattt ggtattcctt atgatatagc tgtaattata ggagttatag
    22501 ttatcattat atatacttat acatcaggaa tgtggggagt tgcagtatca gcatttattc
    22561 aacttgctat ttgtatagtg tttttgccaa tagtagctta tataagctta aaattagttg
    22621 gcgacaaccc tttacttatg ttacaatcaa tggtaaaaga accattcttt ccaggaaata
    22681 aatcgattag tgattttatg tatacagttt taccattagt tttaggctca atattttctt
    22741 atgaaagttt tttaagatat caatgtgctg ataatgctaa aaatgcagtt aaaagtagtg
    22801 taattgcagg atttatacta ttatttcttg ctttccctat aggaataatt ggagctattg
    22861 gtggtagttt atttccaaat atatcatctg ttcaggtttt acctcaaatg atatcgacta
    22921 ctttgccacc tttaatatct gtattattct tagctgctat attggctgcc ataatgtcta
    22981 ctgccgattc attaatgacc tcaatgagtg ctattatatc aagagatatt tataacaaat
    23041 tattacatcc taatatagaa tttaatgatt taaaaaatac tctaaagtat tctcaaattg
    23101 catcagcttt gacagctata ataggtgcaa tcatagcact taaatttgat agtttattag
    23161 aattattgtt ttggccagct ccattatgta caggtgtaat atttgcacca tttgtaattg
    23221 gtctttgctg gaaaggtgct acaaaaaaag gagctatcta tgctgttata gtaagtgtta
    23281 tattggcatt attaaatatg attggtattc ttactgtatt tgacagaatt ttggttccta
    23341 taataggtgg ttctattaca atatttatag ttagcaaatt ttcaaaaaaa gattgaaaag
    23401 agaggtatac acagtaaata tgtcaaaatc agaaaagggc aaagaaacaa aagctagtat
    23461 tataagtgct gctagagaat tattttttga gcaaggttat cataagacaa caactaggca
    23521 aattgcagaa agagctaata taaatttagg tctaataagc tattacttct caagtaaaag
    23581 cgaaatagga gctataatat atgaagatat aagaaatgaa atgcagtctt taatctataa
    23641 ctaccatgaa gaaggtacta tgatgatgtt ctttcttgct atgaatgctg acctttgttt
    23701 ccttctaaaa aacgaagcat atagaaattt ttatttggat atagcttatg aagaagctat
    23761 tttaagctat caaagaagtg taaccgaaat ggtcatgaaa agatatgtta atgataaaga
    23821 atctatagaa catgatgaat taatactttc ttgtattggt atacttgcta tgaaacctga
    23881 aataattaga gtttatactt cacacaagta cgatatatct tctcaagctg taataaagca
    23941 ttttacaaaa cagtttctta ttaatcttgg tcatagtacg gatttatgcg aagagatttt
    24001 agaggaattg agtaaatact atatagatat agttgacaat tttactccaa taataactcg
    24061 tgtaagaact taataaaatt ttattaaatt cttagagact gaaattttaa aatcataatt
    24121 tgattttagg atttcagtct ttatcatatt taaagatatt ttatagtata cctgttaata
    24181 ccataagtgt actatccaat tatatctata aatttcttta tccataaatt ccaaagacgc
    24241 cattcatgcc cccctacaca ctcttcatat tcaacatcta cacccagaga atctgcatat
    24301 tttttaaaca tctgattatt tttatataaa aaatctctat caccacaaaa ttgataaatt
    24361 ttaggaatat cttcatttct ttctttaagg ttcttaagta tgtaaagtaa atcattctca
    24421 ctatttctag cgtcttctgg tctaccaaaa tcgtgaaata gaatgtctgc attggtttct
    24481 atttgttgat tttctaactc atgaatcata tcaggcgaac cagaaaaact tgcaactgcc
    24541 gaaaactctt ttggttttga aagcgctaat tttaaagctc catatccccc catagacata
    24601 ccagctacaa agttatcttc ccttttatct gataaaggaa atatagctct aacaaattta
    24661 ggtaattcct cgcttacaaa agtaaaatat tggtgtccat acgccatatc agtataaaaa
    24721 ctagtttcta ctcttggtat tactagggct atatttttat ttttagcata atgctctaca
    24781 ttagtatatc taatccatga gctttggtca tcttctaaac catgaaataa gtataatgtt
    24841 ttaaatttac cttcaaaatc atatatctct ttaccactaa aaagttcttt tccatttgct
    24901 acaggcaaaa ttacaattat atcagtttct cctccagtat atttagattt aaatttacat
    24961 tctataaatg ccacaaaaaa cacctcttct ataataattt tatatctaaa aagcaccaag
    25021 agtttaactt tctcagtgct ttaaatattg cttaatttat atatttttaa ttatacataa
    25081 tattttttag ctacatataa tcggaagtat ctgtcggtaa tccctttttg tccaatttac
    25141 tttcaacaat atccttaatt atagaataaa ttactgcaaa cattggaact cctataacca
    25201 ttccaataaa acctaataat tttcctgcaa ccaataagga gaacaaaatc caaaatgcag
    25261 atataccaat tgaatctcca agtattttag gtcctataat atttccatct atctgttgta
    25321 ttattaatat aatcaacaat aaccagaaag cttttatagg agatacaaac atcactatta
    25381 gcgtagatgg tatagctcca aataaaggtc caaagaaagg gataatattt gtaataccaa
    25441 ttataactga tattaataat gtatatggca ttttaactaa cgtaagtatt acaaatgtta
    25501 gaatacctat aatgaatgaa tctaatattt tgccacctaa aaatcttcca aatgtatagt
    25561 tacttctatg agttaattct aaaattctgg cagcttgttt ttctgtaaat actgcataag
    25621 ttattttttt gcttaatcca tagaattttt ctttatcaat taataagtac actgaaacaa
    25681 ttaatcctag tacaatattc catatactag aggctacatt ctttaacata cttcctaata
    25741 ttgggattaa atctgttaca aactttataa tatatgtaac aaattcattc cacttatcaa
    25801 ctgccaaatt aaagtattgc tcatcaagat ttaaatcagt cattaattta tcaataagct
    25861 tagttgcatt gtttacatac ataggtatat catttgctag tccaacaata ctctcaatta
    25921 cttgtggcaa tacgaaatgc ataaataagt aaagtatcaa tgtagctgtt gcatatgtta
    25981 ataaaagacc caagcctctt tttgaacttt gttttagttt ttttaatttc tcacttttta
    26041 taaaaattct gtcttcataa aactttaaaa taaaattaag aagatatgca atagcaaatc
    26101 ctattataaa aggttgtaat gttgtaaata tagcatctaa attattagaa aatacatcaa
    26161 tttgtgatga tactagataa aatataatac tactagcagc tattataaat gtataaattg
    26221 ctattgttgt gtattttgta ttccaattaa ttttcatttt ttcctcctta tttctatata
    26281 attaaatttt atcacaaaat caccactttt ataacaaata taccaaatta aaaataaaat
    26341 atattcagaa tacaaatact caattttatt tatatttatt attctacaat ataacctaca
    26401 ttatcttttt aagaacctta attaatttat tatcgtatgg agcatatcta atagggacat
    26461 ccaaatttaa tttttttaac acactcttat agtgagtaaa tgtatcgaat ccagcttttc
    26521 catgatatga gcccatacca ctttcaccaa taccaccaaa aggtaagtaa ttcgtagcta
    26581 tatgagtaac tgtatcattg atacaacatc cgcctgctgg aatcatttct aaaagtttat
    26641 tttctaggta cttatttttt gtaaaaatat aaagtgccaa tggatttggc atttgtataa
    26701 ttttttgtat tacttcatct aaatctttat atgttaaaat gggaaatata ggcccaaata
    26761 tttcttcctt cattatatta tcatcccaat taacattgtc tactatagtt ggctctatct
    26821 ttaatgtctc cttattataa tttccaccat agactatctt atctttatca ataagagata
    26881 atatccgatt aaaatgtctc tgatttatga ttttaggaaa ttgctcatta ttacatgcat
    26941 tatccccaaa atacttatta gtataatatt ttattttctc tattaactca ttttttctat
    27001 cttcatgcac taaaacataa tctggagcca cgcaggtttg tcctgcattt attagttttc
    27061 cccaagtaag tcttttggca gtaaggtcta tattagcatc ttttaaaatg atacaaggac
    27121 tttttcctcc aagttctaaa gtaataggag ttaaatgctc tgatgctgat ttcatgatta
    27181 ttttaccaac attagtactt cctgtaaaaa atatataatc aaatctttcc aatagtaact
    27241 tttcactttc ttcttgactt ccttgaacaa ctgcaacata ttcttttgaa aaagtatctt
    27301 caactatgtc tttaactaca ctagatgttg acacagaata ttcagaaggt tttaatataa
    27361 cacaattccc tgctgctaat gaccaaacta atggtataag tgctaattga aatggataat
    27421 tccaaggtga cattatgaga gtaacaccat aaggttgtgg aacaactttg gatatagatg
    27481 gaaaattaac catacttgat ttaactcttt ttattttgct ccattttctt atattcttta
    27541 tagcaaagtt taattcacta taaaacatgc ctacctctgt cataaaacct tcaaaatccg
    27601 atttatttaa atctttcttt agtgctaaaa gtattttttc ttcattttgt gatacaacta
    27661 acttaagttt cttcaactgt tctatacgaa acgatatatc tcttgtttta cctgtattat
    27721 aatattttct ttgcatttta actaactctt ttatatccat tgttaaaaat cctttcttta
    27781 agaattatac taatacattt ttagaaaaag atttaaattt atcctaacat tattttttat
    27841 atcataataa attcatctca atataacata aatcttccaa taaaaaaagc cccttattaa
    27901 gtataagtaa gcttataaaa tagtttattt taaaataaac attttttaaa attataacct
    27961 tattgaaaca attaaattat ccatctttaa taatattatt ttataaataa tgtctagtaa
    28021 gtttctatga aatctaactt tagataataa ataattacaa atatatacct cttaaagttc
    28081 tcttatataa tcaagtattg gagttaaatt ttctttatta caccaatcaa aggcttctcc
    28141 agacaataaa ggtgcttctg ctggtttaag accttgacgt tcttttttag ctatagattt
    28201 tttaaaaaaa ctacaaagag tataatctat aaaagacatt tttgtctcat cccatgcccc
    28261 acgacaataa aagcaaggaa ttttgtttaa ttcatcctta aaatttactt ctcttaattt
    28321 ctttattact tcatcatcat atggagcagc tcctacgcca aatactacta aatttttttt
    28381 ctgcaattct ttataatttt tttttaagaa agaaattccc gctatattac aagcataaag
    28441 acctcctcct aaaataatcg tatcatactt cataaccttt tctatattaa tattcttagt
    28501 ttcaaaaata tcacaagaca ataattctga aagccattta gcatattttt ttgttgaacc
    28561 atacttactc ttataaatca ctactacatt tttcatataa attatccccc tctctgatgt
    28621 catacaaagt tgatttgata cttgcttatt ctccaacgtc attattttct acataatttt
    28681 tcacattttc aattcctata cttaatttca taattccaaa aaataactgt tccacttctt
    28741 tctctgtaaa atcttcaaat aaaagctgta atactttttc ctgcatacct cttacttttt
    28801 tagaatactc ttgcactcta tcttttgtca caagacagat agctcttgaa tctttttcat
    28861 tctgctcaat ttgtataaaa cctttctttt ctaaagcaat agctagtttt tttacatttt
    28921 gtcttgagca ccccattaat tctccaagtt tggttaatgt aagagtttca tctacagagt
    28981 ccgcaatagc taaaagtaac cattgtttca ttgttaattc tgggtctaat ttatcacatg
    29041 tagtttgaag tttattttgc attacaaata tacttgcaaa tatagcttgt tttctactat
    29101 catcatctac catatatttt ttcattaaac tttctgcatc cattattata cacttctctt
    29161 tatcttagat tttaattttt tgataatttt aaatagtaac taattacttt atattatagt
    29221 aattagttac tattatgtca ataaatttat t
//
LOCUS       DAEHWM010000043        27922 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.044, whole genome shotgun sequence.
ACCESSION   DAEHWM010000043 DAEHWM010000000
VERSION     DAEHWM010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27922)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27922)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27922
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.044"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(344..721)
                     /locus_tag="KNP36_001994"
     CDS             complement(344..721)
                     /locus_tag="KNP36_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0873867.1"
                     /translation="MTITKIPPAELKVMKFIWSSDFTVASKDVIEAMEKLYNWKQTTT
                     LTLLSRLVNKQFLSARKIDRHTHYTVLIGEEEYLHFETKTFLDNMHGSSIESFMKSLF
                     KKGVNEEELNSVEKWVKDIKKDE"
     gene            1062..2174
                     /locus_tag="KNP36_001995"
     CDS             1062..2174
                     /locus_tag="KNP36_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBF0873868.1"
                     /translation="MNAFIRKRNKNYVVYLEFEDEKTGKRKQKNMGTFDKKREASKRL
                     NEVKESLYNDGFLVPSEITVSEFLLDFLNKYSENISLATYNNYVSICKNYINPSIGKY
                     KIQDLHPVHIQNYIDKLSYKLNPQSIKIHINILKLAIKRAYRLKLIKENVMDSIEAPR
                     YKKFKNEIYDREQMIKLLDLAKNTEMELPINLAIGLGLRISEVLGLTWDNIDFEENTI
                     TVNKITSRINGSVILKEPKTESSVRKISSPKELMSLLKEYKIKQNKNLLKSSIRNNNN
                     LLFFNKKCEPIAEDVMSKKFKRFLEKNELPHIRFHDLRHSHVTLLINSKVPIKVISER
                     VGHSNISTTLSVYSHVLKEMDKEASDKISESLFNAN"
     gene            complement(2382..2858)
                     /locus_tag="KNP36_001996"
     CDS             complement(2382..2858)
                     /locus_tag="KNP36_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873869.1"
                     /translation="MVKKRLVAVVISLAMISVGNFSYAHSGGHNSSGGHHNKNKSELT
                     RYYCGGHSAHQHNKGFCPYASTKENSGVTISSVHNEKNHKNYFAEKGYNKGYEDGCKG
                     LYNLSVTEAKSDNLYEKEILKSSYEKGYLIGYNEYKAKKVDDVMKKMLDIPMLASI"
     gene            complement(3057..4682)
                     /locus_tag="KNP36_001997"
     CDS             complement(3057..4682)
                     /locus_tag="KNP36_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0873870.1"
                     /translation="MLQVTGVGLRFGDKELFKDVNLKFTKGNCYGIIGANGAGKSTFL
                     KILSGEIEPNTGSISITDKERMSVLKQDHFEYEEETVLNVVIRGHERLWNIMKEKDAL
                     YMKEDFNEEDGIKAAELEGEFAELDGWDAETNAEKILMGLGITKDMHYKQMKELVGGE
                     KVKVLLAQSLFGKPEILLMDEPTNHLDFKSINWLNNFIMDLEESIVIIVSHDRHFLNQ
                     ICTNIVDVDFGKIQMYVGNYDFWYESSQLALQLAKDQNKKTEEKIAQLKEFIARFSSN
                     ASKAKQATSRKKQLEKLEVEDIQPSRRRYPYVGFTPAREIGNEVLEVHNLTKTIDGVK
                     VLDNVSFRLDRDDKVVFMGDEIATTALLNIVMGELEPDSGEYKWGVTTSQDYLPKNHN
                     KFFDGVEYSLVDWLRQFSEEKSESFIRGFLGRMLFSGEEALKEAQVISGGEKVRCMLS
                     KLMLSNANVLVLDDPTNHLDLESITSVNKGLEKFPGVLLFTSHDHEFISTIANRIIEI
                     TPNGIMDRKMDFDEYLESKEIQDQLAKMYGKDK"
     gene            complement(5020..6039)
                     /locus_tag="KNP36_001998"
     CDS             complement(5020..6039)
                     /locus_tag="KNP36_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-binding protein"
                     /protein_id="HBF0873871.1"
                     /translation="MKLIKTIDAVGQVLCHDITQIIPGEFKGRKFKKGHIVKEEDIPV
                     LLSLGKDNLYVWEKSEGMVHENEGALFLKELTAGENLDFSEIKEGKIDFIAACDGLLK
                     IDVDALFDLNCVGEIMMATLHNNFIVNKGLKVAGTRVIPLVIDEKKLEDAKKVVGNRK
                     IVNVVPFKPKKVGIVTTGNEVFYSRIVDKFGPVIEEKVKGFGCEVIGQTICPDDKEII
                     KSAIKEFISQGAELICCTGGMSVDPDDVTPTAIKETGADLVTYGSPILPGAMFLLAYY
                     GEVPIMGIPGCAMYHKTTVFDIVLSRVLIDEKLDKYDIARYGHGGLCMNCDVCTYPAC
                     NFAKI"
     gene            complement(6036..6605)
                     /gene="mocA"
                     /locus_tag="KNP36_001999"
     CDS             complement(6036..6605)
                     /gene="mocA"
                     /locus_tag="KNP36_001999"
                     /EC_number="2.7.7.76"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdenum cofactor cytidylyltransferase"
                     /protein_id="HBF0873872.1"
                     /translation="MINAVIMASGFARRMGANKLLLNYKGCSIIEHVFREVSKIDFHQ
                     VVVVSQYEEVLLLCNKYGFEYIDNKNANIGQSESIKLGVLNSSKCDGYMFFVGDQPFI
                     DNLYIDKIINTFKLDRDFIVIPRYKDMCGNPVIFPYSKKEELLALKEDEKGKTILKNS
                     SKIKYVEVPKEMLFDIDTKMDYERIGGKL"
     gene            complement(6712..7434)
                     /gene="yqeC"
                     /locus_tag="KNP36_002000"
     CDS             complement(6712..7434)
                     /gene="yqeC"
                     /locus_tag="KNP36_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative selenium-dependent hydroxylase
                     accessory protein YqeC"
                     /protein_id="HBF0873873.1"
                     /translation="MELSNIIEKNEIITVVGAGGKTSFINYFANFYRNKLKVLLTTTT
                     KIYVPNDYDNIIITIDGTVIPSICHGITVCGSYINNENKLVSIDSSILDEIVDQFDLV
                     LIEGDGSKRKKLKGWNAKEPVVYHRTTKTIGILDITSFGMNINEENIHRVEIFKKIAN
                     LDTSSINSSSTVSIENLKNIVLNPNGLFKNYSGKRVLFINKVENEKYKNLAIKLIENI
                     KEYESEIEIFYGSVKQKFCVRY"
     gene            complement(7617..8894)
                     /locus_tag="KNP36_002001"
     CDS             complement(7617..8894)
                     /locus_tag="KNP36_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0873874.1"
                     /translation="MSNRIKNIHYGTQRQQLKNLTKKEYQALREMCFLAKNLYNVGTY
                     NVRQHYFNQGEHLNYEANYHVCKENENYKLLNSNIAQQILKEVDSSFRSFFGLIKLAK
                     EGKYDFRGIKSPKYLDKEGFFSIIIGQIRIKEDGILNVPMSPAFKKLYGKVSIKVPQN
                     ILEKKIKEIRIIPKHKARFFEIQYCYEIPKSEEVSNQKNALAIDLGLENLCTCVTNLG
                     DSFIIDGKRLKSVNQWANKQNDKIEALKLKKNITAITRKQFKVWNKRNNQVKDYVNKT
                     CFYIIDYCVKNNIGNLIVGYNAKLEKSDNMERKIYRNFIRIPFGEIKGKLEYLCKIKN
                     INFIRQEESYTSKSDFFADDFLPDINVDNVKKYDFKGERITRGQYKSSVGIIINADVN
                     ASFNILKKSQVVNLSNLQNNPQILKQPQRVRIS"
     gene            complement(9033..11339)
                     /locus_tag="KNP36_002002"
     CDS             complement(9033..11339)
                     /locus_tag="KNP36_002002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBF0873875.1"
                     /translation="MINKGIRKIDSTAIVTGKPLYTEDLIMHKDVLTLKLLRSPHAHA
                     KIKNIDTSKAEKIPGVVGIYTYKDVPQVRYCVPGQTEPEASPYDRVLLEDTVRFIGDE
                     VALVAAEDEKTALKALKMIKVDYEVLKPVFDAREAEGNEVVIHPEKDIVEPYPFGLDA
                     KNNIVSKEFFEFGDVEAKLKESDFVVESSYKTQSQSHCMMETHRSYSYKDINDRIVVV
                     SSLQSPHNVKRILRKVLGIPSSKIRVIKPRIGGGFGGKNIAATDIFTAFVTMKTGRPA
                     KFVFTRSETFVGSNSRHEMFFDVKVGADKEGNLKAIELKSLNNTGAYGGNGVSVSSES
                     GHNTLPIYNDIDAVRFNARTVYTNRLPAGALRGYGATQGIFAIDSAIDELAHKIGMDP
                     LEFRIKNIIDRYTNGKAAEDEILSCELRQCIEKGKKLINWDDKYPCKDIGNNKVRAVG
                     MAVANHGSGIPRVDMATVTIRMDEDGTYKILSGLADLGQGADTIQAQIAAEALNTTVD
                     RISIYTGDSDLCPYDTGAFASCTTTVTGNATIKTANKLKDILLSVAESKLGFKKEDLE
                     LGKDRVFVKNDNSKFVLLEELGRESVGGIGFASDDVPVVLEATESFGMLKKIKPFIAG
                     FAEIELDKNTGEYKVINFACVPDCGTVINPTLARIQVEGGVMMGIGFAMYEDPIFDKD
                     GRLLTDSFLQYKVPTKKEVGNILVDFAENFDPGGPYGAKSLGEIVIHTPAPAIANAIF
                     NATGVRLRELPMTFEKVYMGMKNNNKQL"
     gene            complement(11332..12126)
                     /locus_tag="KNP36_002003"
     CDS             complement(11332..12126)
                     /locus_tag="KNP36_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBF0873876.1"
                     /translation="MVTIKEYSVPQSLEEAYKILISKKNNVILGGCGFIKLSNKNIGT
                     AIDLKDINLNYIKEDKKNILIGADTSLRSLEIDKTIKNYCSGILSSAVSNIVGVQFRQ
                     GARIGASVFSKYGFSDLIPALLVVGAKVRLYNKGILELSEFLDSELSRDILVEVILPK
                     KDAIAVFDSIRKCTGDFSVLNSAMLKENDTYKIAIGARPQKARLALEASNILNKEKDI
                     DKASIVASKELTYGSNMRASKEYRKDMASALVKRMYNAIEEGMYND"
     gene            complement(12233..13591)
                     /locus_tag="KNP36_002004"
     CDS             complement(12233..13591)
                     /locus_tag="KNP36_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine/pyrimidine permease"
                     /protein_id="HBF0873877.1"
                     /translation="MKAKSTSKFELDGIPPLKEAIPLGLQHLMAMVIGSCLPAILIAN
                     AAGLNHKMSTLLIQAALVFAGLSTLLQLYPIPLFKGFKLGGGIPVIMGATAMFIGAGV
                     SVASKYGLPVLFGSQIIAGIVIIIIGFGLKKIRFIFTPAVSGTIVACMGLGLFPIAIK
                     NLAGGMGNETFGNPINFIVGISVSLMILGLNKYGKGLFKDASILVSIIFGYILSLILG
                     IVNFSSIQEFTLVALPKPLAFGLDIRLEVVVMFSIIYLVEIADIMGACTLSAVGGLNR
                     QVTDEELSSAVLGNGVLSTIGALFSATPMGMFGQNSAIVSNTKVVSKFVLAIGGIGLF
                     LAGISPLLANLIRTIPPCVVGGATLVIFSTLTTSGLRLVSMDGFNQENSMILGLSMAS
                     GIGFMVAPQVLEKFPKFIETLLADSSVVSGAMVAIIIQALYMVKFPGNKSDKVEDKNK
                     SL"
     gene            complement(14938..15987)
                     /locus_tag="KNP36_002005"
     CDS             complement(14938..15987)
                     /locus_tag="KNP36_002005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873878.1"
                     /translation="MVMQVQEKILELLYTINEDVVSIKNDMSEVKQEINVLKEDMSEV
                     KQEMTVMKEDMSEVKQEINVLKEDMSEMKQEMTVMKEDMSEVKQEINVLKGDMSEVKQ
                     EMIVMKEDMSEVRQEINIMKEDMSEVRQEINTMKEDMSEVRQEMTVMKEDMSEVKQEI
                     NVLKEDMSEVRQEINIMKEDMSEVRQEMTVMKEDTSEVKQEINVMKKDMSEVRQEITV
                     MKEDVSEVKSEVNFMQNKINNINEDMNGIKDEVSIANEKLYGIEIKIDSLECEDKSMK
                     EIQIEQNNILGSLLHNSEINKATHDNIEHNIAYIKGDTNSIKEDIAEIRRDLNLVELA
                     TSKNWSDIVKLKSVK"
     gene            complement(16217..17302)
                     /locus_tag="KNP36_002006"
     CDS             complement(16217..17302)
                     /locus_tag="KNP36_002006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HBF0873879.1"
                     /translation="MYNFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIR
                     KERAINPAPHMVRNTANALLNNEKWTDFEPEQWIDFEIPQMKRDGTVCIASIGHTIEE
                     SSELVEKVANAGADFIELVSYDYRDLIPMLKDAKERVNIPVIVKLPPMIDEIGDFAKK
                     LEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYLSGETIKPITLQRIYEIKKQV
                     NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRLGYN
                     TIENACGIVHNHMGDVNERLSFEFTYDEEKCTKCKMCERVCAYQARKLNDKMELNEEE
                     CRYCGLCISVCKPKALGRKISCSELNV"
     gene            complement(17338..18651)
                     /locus_tag="KNP36_002007"
     CDS             complement(17338..18651)
                     /locus_tag="KNP36_002007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBF0873880.1"
                     /translation="MIAIKSKYLISSADEIYTNSAVVVENDIIKDILPNEEVEIKYKN
                     IEEIIDKSDAIIMPGFVNGHMHQYGVLSRGIPANVHFTDFEGFLNDYWWPFIENRIGL
                     KEVKATTKASAIELIESGVVAFCDTLEAPNTEEGTLIEQGKILEEIGMKAILSLESCE
                     RISFENGLRCLDENSNLIKWSRENSKLINGIMCTHTSFTCSDRFIKKAKEDAKKLNAP
                     MQFHLCESIYEPNYAEKHFGKKAVDYYNDLDILDETVLASQCVKVNDEEIDILKEKGV
                     KVVHMPLSNCEVGGGFSPVPKMIKKGIKVALGTDGYINDFFEVMRGAFLMHKSVEEDA
                     SVMPANLVFRMATEHGAYVLGLQNSGKIAVGNKADIIVMEDEFKTPVTLDNIFDQIVV
                     QGKKEFISNVYIDGRHILKEKQLVDLDKKAIVKEMKEVACEFWKF"
     gene            complement(18652..20943)
                     /locus_tag="KNP36_002008"
     CDS             complement(18652..20943)
                     /locus_tag="KNP36_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBF0873881.1"
                     /translation="MVNKEVRKIDSEAIVTGKPIYTEDLIFHKDVLTIKLLRSPHAFA
                     KIKNIDIKNALKVKGVVNIFTYKDVPNYRYSMVGESYPEASPHDQLILEDVVRYVGDE
                     VAIIAAEDERAAIKAMKLIKVEYEVMTPILDARESEGNKILIHEEDDLFCPFDFGLDA
                     TKNIVSREKMGKGDVEKEFKESDVIVEHSYMTQSQAHCMMETHRAYTYIDTNGRLVVT
                     SANQSAYHMRRQVSKALGIPLSKVRVIKPRIGGGFGGKNIAVTEIYASFVTWMTKRPA
                     KLIYTREETFAMTNTRHQMFFDIKIGADKEGNIKAIDMKALNNTGAYGDNGPSVCSES
                     GHNVLPTYNNVPAIKFDGKTVYTNLVPGGALRGYGATQGTFALDCAIDELAHKLNMDP
                     TEIKLKNIIKKQTEGGIMNFPIRSCALDECIIRGKKLIGWDEKYPVRDIGNNKVRAVG
                     MSVGTHGSGIANIDMAIVNMRMDEDGTYKLFSGSSDLGTGSDTILAQIAAKALNTSID
                     RISVYTGDTDMCPYDTGAYASCTTYVTGNATIKSAESLKQKILKVAQKKLDLPIDDLI
                     LYEDRVCYSEDVEKFVLLSELGKESVGGGNQEVLYSSESYGIQESAKPFLAGFAEIEL
                     DKTTGEFKVINYACSTDCGTVMNPALARIQVEGGVTQGIGLAMYEDPRHGSDGKLQTS
                     NLLQYKVPTKKDIGNIIVDFVDNYEPTGPYGAKSLGEIVIHTPAPAIANAIYNATGVR
                     IRELPITSEKVYMAMKKLNQGGK"
     gene            complement(20933..21727)
                     /locus_tag="KNP36_002009"
     CDS             complement(20933..21727)
                     /locus_tag="KNP36_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBF0873882.1"
                     /translation="MITIKEYVVPKSLDEAYELLISRKNNIILGGCGFLKLGSKNIGS
                     AIDLKDLALDYINETDDSILIGADTSLRTLELNKVIKNYCNGVISNAVSNIVGVQFRS
                     GARVGASVFAKYGFSDLIPSLLVVDAKVKLYKKGVMNLADFLENELEKDILIEVILPK
                     KDAIGVFDSIRKCTGDFAVLNGAMLKEGSIYKIAIGARPRRAKIAYKASEILSLENDI
                     EKAGEVSSEELSFGSNIRGSKEYRKDMTKALVVRMYNSIGGECDGK"
     gene            complement(21766..22212)
                     /locus_tag="KNP36_002010"
     CDS             complement(21766..22212)
                     /locus_tag="KNP36_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2Fe-2S iron-sulfur cluster binding
                     domain-containing protein"
                     /protein_id="HBF0873883.1"
                     /translation="MIIKCTINNKEKELSIRPDDFLADTLRENGYVSVKKGCDTGSCG
                     LCTVMVNDKAVLSCNYLTARVEGQHITTLEGVLDEAKKFGDFLADEGADQCGFCAPGF
                     IMMVLAMKRELQNPTEEEVIDYVNGNLCRCTGYKGQLRAIHKYLNT"
     gene            complement(22284..23690)
                     /locus_tag="KNP36_002011"
     CDS             complement(22284..23690)
                     /locus_tag="KNP36_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0873884.1"
                     /translation="MMDILIKNAIIVTVNKEREVIFDGALVVKDNKIADIGNSKEIES
                     KYTDVKKIIDAKGKVLFPGFINTHNHLFQTLLKGLGDDMVLKDWLETMTFPAANYLEP
                     KDTYDAAMLGCIEGLRSGITTMVDYMYPHSKPGLCDGIIDAYKELGIRGILGRGCMNT
                     GAQFGVHPGIMQDVETVEKDVRRLFEKHHNTENGRIKIGVAPAAIWSNSQEMLEMLWR
                     VVKEYDDALFTVHISETPFDREAAKELHGQYDIDVLEKLGILGPNVLMVHCVYLTEKD
                     MELTKKYDMKVSHNTASNMYLSSGVAPVPEMLKKGITVSLGVDGAASNNSQDMLELMK
                     LTALQHKVNKCDPLAMSAEKVLELATIDGARAIGMEDEIGSLEIGKKADLLIFNPMLS
                     PKAIPMHNPVSTLVYSSSMKNIESVIVDGNIIMEDSKILTANEEKALKDAQDTAERLC
                     IRGTIKNRMEGHKWNSLY"
     gene            complement(23708..25078)
                     /gene="hydA"
                     /locus_tag="KNP36_002012"
     CDS             complement(23708..25078)
                     /gene="hydA"
                     /locus_tag="KNP36_002012"
                     /EC_number="3.5.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropyrimidinase"
                     /protein_id="HBF0873885.1"
                     /translation="MGTILRGGTIITSDKTYISDLRIEDEKIVEIGNNLEINGDKVID
                     ATGKIVIPGGIDTHTHFDMNAGSITTADNFETGTRAAIAGGTTTILDFAEANEGENLL
                     QGVEAYHKKASGNCYCDYGFHMTITCLNKDTFNHMEKLISDGIVSFKMYMAYDGMKVD
                     DGTIYRVLKKARDLGCIVGFHCENGDLLDVLIEENIQNGNLEPKYHPLTRPNIVEKES
                     VSRLADITKLSNSKSYVVHLSCRESLETVKIAREKNIDMIVETCPQYLLLEDNLYNKD
                     KFEGAKYVMSPPLRKKEDINYLWEGLSSGDIQTVGTDHCSFNFKGQKDLGIDDFSKIP
                     NGAPGVEHRLALLYTYGVLENRISVNKFVEVTSTNAAKIFGMYPKKGEIAVGSDADIV
                     ILNINKEETISYKTQKQNVDYTPYEGFKVKCKVEDVFLRGNHVVQSCNVKEHPTGQYI
                     KRKITK"
     gene            complement(25211..26398)
                     /locus_tag="KNP36_002013"
     CDS             complement(25211..26398)
                     /locus_tag="KNP36_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YgeY family selenium metabolism-linked
                     hydrolase"
                     /protein_id="HBF0873886.1"
                     /translation="MLNEQRKQEVTEICQKLIQNPSSSGNEEGVVKAIEESFEKLGFD
                     SWSRDRYGNIVGCIKGNKPGKKILFDGHIDTVPVPDASKWSVPPFEGKIVDGKIYGRG
                     TSDMKGQYTAMMSAVAYFAKDTNRDFAGELYVAGVVHEEIFEGVSAREISKAVQPDYV
                     VIGESSELNLKIGQRGRGEIVVETFGKPAHSANPEKGVNAVYKMANVIQKIQQLVPPT
                     HPVLGDGILVLTDIKSSPYPGASVVPDYCKATFDRRLLVGETREGVLAPIQALLDEMM
                     KEDPELNAKVSYAVEKADCYTGNTIESERFFPGWLYDEEDEFVQAAYKGLKEAGIDSE
                     ITQYSFCTNGSHYAGEAGIKTIGFGPSKENLAHTIDEYIEQEQLFIGTEGYYGILKSV
                     YGK"
     gene            complement(26525..27739)
                     /gene="dpaL"
                     /locus_tag="KNP36_002014"
     CDS             complement(26525..27739)
                     /gene="dpaL"
                     /locus_tag="KNP36_002014"
                     /EC_number="4.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopropionate ammonia-lyase"
                     /protein_id="HBF0873887.1"
                     /translation="MLKEIKWKVNNLPKGDKENCIKFLNEEEITKVRNFHKSFPQYKE
                     TPLANLEGLAKKLGVAGVYVKDESYRFGLNAFKVLGGSYSMGRYLAQRLDTDISELGY
                     DKLTSKEIKEKLGEITFFTATDGNHGRGVAWTANKLGQKSVVLMPKGSSEFRLNKIKG
                     EGADASITDLNYDDAVRLANDYAEADDHGVMVQDTAWDGYEEIPAWIMQGYGTMAQEA
                     IEQLKEYGVDRPTHVFVQAGVGSLAGAVQGYVASIYDECPITVVVEADEADCYYKSAE
                     AGDGKPRFVGGDMPTIMAGLACGEPNTIGFEVLKNHAAAFVSAPDWVSAKGMRTLGNP
                     LNGDEKVISGESGAVTTGLLVAAMEREDLADLRKDLKLDENSRILLISTEGDTDPDKY
                     RSIVWDGEYPSI"
BASE COUNT         8677 a         5267 c         2906 g        11072 t
ORIGIN      
        1 tgtttaatac aatctattgt atacttatct taccctagaa ataatcaaaa caaaaataaa
       61 attatgccct ttatatctaa aacaattaat ttacatgatt aatatacaaa aattctgact
      121 tttaaattcg tatacaatat caaactaaaa taatattaat gacaaaccca atataaatta
      181 aattcaaaca ggtttgattt tacatcaaac ttattgtatt aatattaaat aacaagacaa
      241 aaatatttat aaaaatcaca aattttacat aaaactttat atttgattca tttaactaat
      301 tattgtaaaa actatttatt ttatgataat taactacacc aaattattca tcttttttaa
      361 tatccttaac ccatttttca acagagttca attcttcttc atttaccccc tttttgaaca
      421 aggatttcat aaaactctca atagaacttc catgcatatt atctaaaaaa gtttttgttt
      481 caaaatgtaa atactcttct tctccaataa gaactgtata atgtgtatgt ctatcaattt
      541 ttcttgcact taagaattgc ttatttacta atcttgataa aagtgttagt gttgtagttt
      601 gcttccaatt atatagtttt tccatagctt caatgacatc ttttgatgct actgtaaaat
      661 ctgaactcca aataaatttc atgactttta attctgctgg tggtatctta gtaatagtca
      721 tatgatttta cactcctctc aaacttctac ataattaaat actatattaa tagacttttc
      781 gagtcaaagg ttttatttaa aatatctcat ccaaatttat taatacaaaa aatttatatt
      841 tttattcaaa attaaacaca caatctatta atataaagat aaatatctat tctataagta
      901 taacagatta tcaaattaaa attctaatat ttgacataat atatacattt tttaaataaa
      961 tatatacaat gtattaaaat gtatgcaact ctatttcaaa attattttgt gatatatata
     1021 tgttataata aatgtataaa attttgattg gtgggttata tatgaatgca tttattagaa
     1081 aaagaaataa aaactatgtt gtttacctgg aatttgaaga tgaaaagaca ggtaaaagaa
     1141 aacaaaaaaa tatgggtact tttgataaaa aaagggaagc aagtaaaaga ctaaatgagg
     1201 taaaagaaag cttatataat gatggttttt tagtaccaag cgaaattaca gtgtcagaat
     1261 ttctattaga ttttctaaat aaatatagtg aaaatatatc tttagctaca tataataatt
     1321 atgttagtat ttgtaagaat tacattaatc catctattgg aaaatataaa atacaagact
     1381 tacatccggt tcacatacaa aactacatag ataaactatc ttataaacta aatcctcaat
     1441 caattaagat tcatataaat atattgaaac ttgcaataaa aagagcttat agactcaaat
     1501 taataaaaga aaatgttatg gatagtatag aggctccaag atataaaaaa tttaaaaatg
     1561 agatttatga tagagaacaa atgataaaat tattagattt agcaaaaaat acagaaatgg
     1621 aattacctat taatttggct attggattag gtcttagaat ttcagaagtt ttaggtctaa
     1681 cttgggataa tattgatttt gaagaaaata caataacagt aaataagata acttcccgaa
     1741 ttaatggttc tgttattctc aaagagccaa agacagaaag ctctgttaga aaaatatctt
     1801 ctcccaaaga attaatgtct ttattaaaag aatataaaat aaaacagaat aaaaatttat
     1861 taaaatcttc cattagaaat aataataatt tgttattttt caataagaaa tgtgaaccta
     1921 ttgctgaaga tgttatgagt aaaaaattta aaagattttt agaaaagaat gaattacctc
     1981 atattagatt ccatgattta agacactcac atgttacttt acttataaat tctaaagtac
     2041 ctataaaggt tatatccgag agagtaggac actcaaatat aagtactact ctaagcgttt
     2101 attctcatgt acttaaagaa atggataaag aggcttctga caaaatttct gaaagtttat
     2161 ttaatgctaa ttaatattaa tttatcttag ctttaaatta gcttagctta ttgagataga
     2221 ttcattaata ttaaatgtat ctatctcaaa ttaataacta cttaaataat ctgttttatt
     2281 ttaatttatc gcctcagtta ttatactttt ttacgaaaaa ttatacttta caataaaaaa
     2341 gatattccct tatagaaaat atctttttaa atactatatt attatatact tgctaacatt
     2401 ggaatatcta acatcttctt cattacatca tctacttttt ttgctttata ttcattgtat
     2461 ccaattaaat atcctttttc atatgaactt tttaaaatct ctttttcata taaattatca
     2521 gatttggctt ctgtgacact taaattataa agccctttac acccatcttc ataaccttta
     2581 ttataccctt tttctgcaaa atagttttta tgattttttt cgttatgtac tgaagatatt
     2641 gttactccag aattttcttt tgtactagca taaggacaaa aacctttatt gtgttgatgt
     2701 gctgaatgtc ctccacaata ataacgtgtt aactctgatt tatttttatt atgatgacct
     2761 cctgatgaat tatgccctcc tgagtgagca tatgaaaaat tccctacact aatcatagct
     2821 aaactaatta ctacagctac taaccttttc ttaaccataa tctattcccc ccaaaatgtt
     2881 atatattttt attatatcat ctactatatt atatttaaat tcttaatata caaaatatta
     2941 ctctattctg ctaataaaca tgtttaaaca atataaaaaa cctcctaata tttgattaaa
     3001 aatttacaca ctcatgcata gcatgtctca aatattaaaa ggttttatac taataattat
     3061 ttatcttttc catacatttt agctaattgg tcttgtatct ctttactttc taaatactca
     3121 tcaaagtcca tttttctatc cattattcca tttggagtta tctctataat tctatttgct
     3181 atagtagata taaattcatg gtcatgagaa gtaaataaaa gcactcctgg gaacttttca
     3241 agtcctttat ttacagaagt tatactttct aggtctaagt ggttagtagg gtcatctaat
     3301 acaagtacat ttgcatttga aagcattagc ttactaagca tacatctaac cttttctcct
     3361 ccagatataa cttgagcttc ttttaatgct tcttcacctg agaataacat tctacctaaa
     3421 aatcctctta taaaactttc acttttttct tcagagaact gtctaagcca gtcaaccaaa
     3481 gaatattcta ctccgtcaaa aaacttatta tgattttttg gaagataatc ttgagaagta
     3541 gttactcccc atttatactc tccactgtct ggttcaagtt ctcccataac tatgtttaaa
     3601 agtgcagtag tagctatttc atctcccata aatactactt tatcatctct atccaatcta
     3661 aatgacacat tatcaagaac cttaacccca tctatagttt tagttaaatt gtgtacttct
     3721 aaaacttcat tcccaatttc tcttgcaggt gtaaatccta catatggata tcttcttctt
     3781 gatggttgta tatcttcaac ttctaatttc tctaactgtt tctttcttga tgttgcttgt
     3841 ttagcctttg aagcattaga actaaatcta gctataaatt cctttaattg agctatcttt
     3901 tcttcagtct ttttattttg gtccttagcc aattgtaaag ccaattgact tgactcatac
     3961 cagaaatcat agtttccaac gtacatttgt attttaccaa aatctacgtc aactatatta
     4021 gtacatattt gatttaggaa atgtctatca tgtgatacta ttataactat agattcttct
     4081 aaatccatta taaaattatt taaccagttt attgatttaa aatctaagtg gtttgtaggt
     4141 tcgtccatta atagtatttc aggcttacca aaaagtgatt gtgctaacaa taccttaacc
     4201 ttttccccac caactagttc cttcatttgt ttgtaatgca tatctttcgt tatgccaaga
     4261 cccataagta ttttctcagc attagtttct gcatcccatc cgtcaagctc tgcaaactca
     4321 ccttcaagtt cggcagcttt tatcccatct tcttcattaa agtcttcctt catatacaat
     4381 gcatcttttt ctttcattat gttccaaagt ctctcatgac ctcttataac aacatttaaa
     4441 acagtttctt cttcatattc aaagtggtcc tgttttaaaa ctgacattct ttctttatca
     4501 gttatagata tactacctgt attaggctct atttctcctg ataatatttt taaaaaagta
     4561 gattttcccg caccattagc tcctattatt ccatagcaat tacctttagt gaattttaag
     4621 ttaacatctt taaatagttc cttatcacca aatctaagtc caacacctgt aacttgtaac
     4681 attaatatat tttcctttct ttttgctcat aatttatttt atcataaaac tttgataaca
     4741 tttttattat atattatcac gtaaatagta tattttttat actaaatttg tgaaatattt
     4801 attaaaataa tactaaaaat tgtaaattta taaaaattaa caatctctta tattatactt
     4861 ataaagaaat caaattgcaa ctttattcat tcttttacac attgaaaata agttattata
     4921 atttctaaat aaatatgctt tttttaaaac atcattctag ctgttttgtt tcatatttaa
     4981 aaagagtact taatttgtaa atactctttt ttaataactt tatattttag caaaattaca
     5041 tgcaggataa gtacatacat cacagttcat acaaaggcca ccatgaccat atctagctat
     5101 atcatactta tcaagctttt catcaattaa aaccctagat aaaactatat caaatactgt
     5161 agttttgtga tacattgcgc atcctggtat acccataatt ggaacttctc cgtaataagc
     5221 aagtaaaaac atagctcctg gtaatattgg tgaaccatat gtcactaaat cagctccagt
     5281 ttcttttata gctgttggcg taacatcatc tgggtctaca ctcatcccac cagtacaaca
     5341 gataagttct gctccttgac ttataaattc ttttattgca ctctttataa tttctttatc
     5401 atctgggcat atagtctgtc ctataacttc acaaccaaag ccttttactt tttcttctat
     5461 tactggtcca aatttatcaa caattctgct ataaaacact tcatttcctg tagtaacaat
     5521 tcctactttc ttaggtttaa aaggtactac atttactatt tttctattac caactacttt
     5581 ttttgcatct tctaattttt tctcatctat aactaaaggt atcactcttg ttccagctac
     5641 ttttaaacct ttatttacta taaaattatt atgaagagta gccatcatta tttctccaac
     5701 acaattcaaa tcaaaaagtg catcaacatc tatctttaat agaccatcac atgctgctat
     5761 aaaatctatt ttcccttctt ttatttcact aaaatctaaa ttttctccag cagttagttc
     5821 ttttaaaaac aatgcgcctt cattttcatg aaccattcct tctgactttt cccatacata
     5881 caaattatct ttaccaagag ataataacac tggaatatct tcttctttta ctatgtgacc
     5941 ctttttaaat tttcttcctt taaattctcc aggtattatt tgagttatgt cgtgacataa
     6001 aacttgtcca acagcatcta tagtttttat tagcttcata atttaccccc aattctctca
     6061 tagtccattt ttgtatcgat atcaaataac atttctttag gaacttctac atactttatt
     6121 tttgatgaat tttttaaaat ggttttacct ttttcatctt ctttaagtgc caacaattct
     6181 tctttcttgc tatatgggaa tatgactgga tttccacaca tatctttgta tcttggaatt
     6241 actataaaat ctctatctaa tttaaaagta tttataattt tatctatata taagttatca
     6301 ataaatggct ggtctcctac aaagaacata taaccatcac attttgagct atttaaaact
     6361 cctaatttta tagattcact ttgacctata tttgcatttt tattatctat atattcaaaa
     6421 ccatatttat tacacaataa caaaacctct tcatattgac ttactactac aacttgatga
     6481 aaatcaatct tgctaacttc tctaaataca tgttctatta tagaacagcc tttataattt
     6541 aataaaagtt tatttgctcc cattcttctg gcaaagcctg atgccattat cactgcattt
     6601 atcatatata tcatccttgg tatttataat atattgatag ttctatgatt tttataatat
     6661 ctctattgat attatctata tatataatat catataaact attttaatac ttcaatatct
     6721 tacacaaaat ttttgtttta cacttccata aaatatctct atttcacttt catattcttt
     6781 aatattttct attaatttta tagctaaatt tttatatttt tcattttcaa ctttattaat
     6841 aaataatact ctttttccag aataattttt aaataatcca tttggattta atactatatt
     6901 ttttaagttt tcaatactta ctgtagaact actattaata ctacttgtat ctaaatttgc
     6961 tattttttta aatatttcta ctctatgtat attctcttca ttaatattca ttccaaatga
     7021 tgttatatct aatatcccta tggtttttgt agttctatga tatactactg gttctttagc
     7081 attccaacct ttaagttttt ttctctttga gccatctccc tctattaaaa ctaaatcaaa
     7141 ttggtctaca atttcatcca aaatagagga atcaatactt actaatttat tttcattatt
     7201 tatataactg ccacagactg ttattccatg acaaatagat ggaataacag ttccatctat
     7261 tgtaataatt atattgtcat aatcgtttgg tacatatatt ttagttgttg ttgtaagaag
     7321 aactttcaat ttatttctat aaaaatttgc aaaatagttt ataaacgaag tttttcctcc
     7381 tgctccaact acagttatta tttcattctt ttctattata tttgatagtt ccacactttc
     7441 acctcttata accagttttc taatctctta attattatag ttaggccttt ttagtaaaag
     7501 tgatttttga aattccataa actcgaaagt aaatagattc tgttgtaaac aacaaggcgg
     7561 atccaattcg ccgctaagct gtaagcttac gctatcagtt tatcttttaa atataattaa
     7621 gatattctta ctctctgtgg ttgctttaat atttgaggat tattctgtaa attagataaa
     7681 ttaactactt gtgatttttt tagtatatta aaactcgcat ttacatctgc atttataatg
     7741 attccaacac tggatttgta ctgtccacgt gttattcttt cccctttaaa gtcatatttt
     7801 ttaacattgt ccacattgat atcaggtaga aaatcatcag caaaaaaatc tgatttacta
     7861 gtatagcttt cttcttgcct aataaaattg atatttttta ttttacacag atattctaat
     7921 tttcctttta tctctccaaa tgggattctt ataaaatttc tatatatttt tctctccata
     7981 ttatcacttt tttctaactt agcattatat cctacaatta aatttccaat attatttttt
     8041 acacaataat caattatata aaaacaggtt ttatttacat agtctttaac ttgattattt
     8101 ctcttattcc aaactttaaa ttgttttctt gttattgcag ttatattctt ttttaatttt
     8161 aaggcttcta ttttatcatt ctgtttgttt gcccactgat tcacagattt tagccttttt
     8221 ccatctatga taaaactatc acctaaattg gtaacacatg tacataaatt ttctaaaccc
     8281 aagtctatag ctagtgcatt tttttgattt gaaacttcct ctgattttgg tatttcataa
     8341 caatactgaa tttcaaagaa cctagcttta tgtttaggta ttattcttat ttctttaatt
     8401 tttttctcta gtatattttg tggaactttt atacttactt tcccatatag ttttttaaat
     8461 gctggagaca taggtacatt taaaatccca tcttctttga ttcttatttg acctattatt
     8521 atgctaaaaa atccttcttt atctaaatat ttaggtgatt ttatccctct aaagtcatat
     8581 tttccttctt tggctaattt aattaatcca aaaaatgacc taaacgaact gtctacttct
     8641 tttaatattt gttgcgctat attactattg agaagcttat agttctcatt ttctttgcat
     8701 acatgataat tagcttcata gttaagatgt tctccttgat tgaaataatg ctgtcttaca
     8761 ttatatgtac caacattata taagttctta gctaagaagc acatctctcg tagagcttga
     8821 tattcttttt tagttaagtt ttttaattgt tgtctctgag ttccatagtg tatatttttt
     8881 attctgtttg acatgaactc acctccttta gaatatactc tactagacat tatatacggt
     8941 atttttacaa aacaccatat ataatgtcca tttaattact ttattttaca aaataattta
     9001 aatttacttg cttttatgca tcttattatt tattataatt gtttattatt atttttcata
     9061 cccatataaa ctttttcaaa agtcatagga agctctctta aacgaactcc tgtagcatta
     9121 aatattgcat ttgctatagc tggtgctggt gtatgtataa ctatttctcc taatgattta
     9181 gcaccataag gacctcctgg gtcgaaattc tcagcaaaat ctaccaatat atttccaact
     9241 tctttttttg taggaacttt atactgtagg aaactatctg ttaataatct accatcttta
     9301 tcaaatatag ggtcttcata cattgcaaac cctataccca tcatcacacc accttctact
     9361 tgtattctag ctaaagttgg atttataact gttccacaat caggtacaca tgcaaaattt
     9421 atgactttat attcacctgt atttttatct aattctatct ctgcaaatcc tgctataaat
     9481 ggttttattt ttttcaacat gccaaaagat tctgttgctt ccaaaactac tggtacatca
     9541 tcactagcaa atcctattcc tccaacagat tctctaccca attcctctaa tagaacaaac
     9601 ttgctattat cgtttttaac aaaaaccctg tcttttccca actctaaatc ttctttttta
     9661 aatcctagct ttgactctgc aactgaaagt aatatatctt ttaatttatt tgctgtcttt
     9721 attgttgcat ttcctgtaac cgttgtcgta caagaagcaa atgctcctgt atcataggga
     9781 cataagtctg aatcacctgt ataaatagaa attctatcta cagtagtatt taaagcttcc
     9841 gcagcaattt gagcttgaat tgtatcagcc ccttgaccta agtcagcaag accagataat
     9901 attttatatg tgccatcttc atccattctt atagtgactg ttgccatatc tacacgcggt
     9961 ataccagaac catgatttgc tactgccata cctactgctc ttactttgtt gtttcctata
    10021 tctttacatg gatatttatc atcccaatta attaatttct ttcccttttc tatacattgt
    10081 ctcagctcac aacttaatat ttcgtcttca gctgcttttc cattggtata cctatctatt
    10141 atatttttaa ttctaaattc aagtgggtcc attccaatct tatgtgccaa ttcatcaata
    10201 gcactatcta ttgcaaatat tccctgtgta gcaccatacc ctctaagtgc tcctgctggt
    10261 aacctattag tatatactgt tctagcatta aatctaacag catcaatatc attatatatt
    10321 ggtaaggtat tgtgtccaga ttcggaagaa acagagacac cattcccacc ataagcacct
    10381 gtattgttta atgactttag ctctattgct tttaaatttc cttctttatc tgcaccaact
    10441 ttaacatcaa aaaacatttc atgtctacta ttagaaccta caaaagtttc acttcttgta
    10501 aatacaaatt ttgctggtct accagttttc atagtaacaa atgcagtaaa tatatctgtt
    10561 gctgctatat tctttcctcc aaatccacca cctattctag gtttaattac tcttattttt
    10621 gaagacggta tacccaatac ttttctaagt attctcttta cattgtgtgg tgattgtaat
    10681 gatgaaacta caacaattct atcatttata tctttatatg aatatgacct atgagtttcc
    10741 atcatgcaat gcgattgact ttgggttttg tatgaagatt caaccacaaa atcactttct
    10801 ttaagcttag cttcaacatc tccaaattca aaaaattctt ttgatactat attatttttt
    10861 gcatccaatc caaaagggta tggctctact atgtcttttt ctggatgtat aacaacttca
    10921 tttccttctg cttctcttgc atcaaacaca ggctttaaaa cctcataatc tacctttatc
    10981 atttttaagg ctttaagtgc tgttttctca tcttcagcag ccactaaagc tacttcatct
    11041 ccaataaatc taactgtatc ttcaagtaaa actctatcat aaggtgatgc ttctggttct
    11101 gtttgacctg gaacacaata tctgacctgt ggtacatctt tatacgtata aatacccaca
    11161 acccctggaa ttttttcggc ttttgatgta tctatattct ttatcttagc atgagcatgt
    11221 ggacttctaa gtagttttaa tgtcaaaaca tctttatgca taatgaggtc ttcagtatat
    11281 agaggttttc ctgtgacaat tgctgtacta tctatctttc ttatcccctt attaatcatt
    11341 atacattccc tcctcaatag cattatacat ccttttaact aatgcacttg ccatatcctt
    11401 tctgtactct ttactagctc tcatattact tccataagta agttccttac tagcaacaat
    11461 agatgcctta tctatatctt tttctttatt taatatatta ctcgcttcaa gtgctaatct
    11521 agctttttga ggtcttgccc caattgctat tttgtaagta tcattttctt ttagcattgc
    11581 tgaatttaat acagaaaaat ctcctgtgca ttttcttatt gagtcaaaaa cagctattgc
    11641 atcttttttt ggtagtatta cttcgaccaa tatatcccta cttaattcac tatccaaaaa
    11701 ctcacttaac tctagtattc ctttattgta taatctcacc ttcgctccaa caaccaaaag
    11761 tgctggtatt aagtcagaaa agccatactt tgaaaataca cttgcaccaa ttctagcccc
    11821 ttgtctaaat tgaacaccaa ctatattaga aacagcgctt gaaagtattc cactacagta
    11881 attttttata gttttatcaa tttctaaact tctaagtgaa gtatctgcac ctatcaaaat
    11941 atttttttta tcctctttta tataatttag atttatatct tttaaatcta tcgctgttcc
    12001 tatattttta ttacttaatt ttataaatcc acatccacct aaaataacat tatttttttt
    12061 agaaattaaa attttatatg cttcttctaa actctgtgga actgaatatt cctttatagt
    12121 aaccatctta tccccccatc attaacttat taaaacacaa aagtttttaa taaatctttt
    12181 atttatattt ataattgtag tatatttaat tcacatatat taaaccttta cattataaac
    12241 ttttattttt atcctcaacc ttatcacttt tatttccagg aaattttacc atatataaag
    12301 cttgaattat tatggctacc attgctcctg aaactacact tgaatctgca agtaatgtct
    12361 ctataaattt tggaaatttt tcaagaactt gaggagctac catgaatcca ataccagaag
    12421 ccatagaaag acctaatatc atgctatttt cttgattaaa tccatccata ctaacaagtc
    12481 ttaaaccaga tgttgtaaga gttgaaaata taacgagtgt tgctcctcca accacacagg
    12541 gaggaattgt tcttattaaa ttagctaata aaggcgatat tcctgccaaa aataatccaa
    12601 ttcctccaat agctagtaca aatttactta caacctttgt attggaaacg attgcagaat
    12661 tttgtccaaa catccccatt ggagttgcag aaaataatgc acctattgta gagagtactc
    12721 catttcctaa aacagcagaa gaaagttctt catctgttac ttgtctatta agccctccta
    12781 ccgcagaaag tgtacaagca cccattatat cagctatctc aactaaatat attattgaaa
    12841 acattacaac aacttcaagt cttatatcta gcccaaaagc aagtggtttt ggaagtgcaa
    12901 ccaaagtaaa ctcctgaatt gaagaaaaat ttactatacc caaaattaat gataaaatgt
    12961 atccaaaaat tatgctaact aatattgatg catctttaaa taatcctttt ccatacttat
    13021 ttaatcctaa tatcataaga gatacagata ttccaactat aaaattaatt ggattcccaa
    13081 aagtctcatt gcccataccc ccagctaagt tttttatagc tattggaaaa agtccaagac
    13141 ccatacatgc aactattgtt cctgatacag ctggagtaaa tataaatcgt atttttttaa
    13201 gaccaaaacc aattataatt attactatac cagctattat ttgagagcca aataatactg
    13261 gtagtccata cttacttgca acagataccc cagctcctat aaacatagct gtagctccca
    13321 ttataactgg tattcctcct cctaatttaa aacctttaaa caaaggtatt ggatataatt
    13381 gtaataaagt tgataatcct gcaaaaacta atgcggcttg aatcaataat gttgacatct
    13441 tatgattaag tccagctgca tttgcaatca atatcgctgg taaacaacta cctattacca
    13501 ttgccattaa gtgttgtaac cctaaaggta ttgcttcctt tagtggtggt attccgtcta
    13561 attcaaattt tgatgtactt tttgctttca taataaaaac tcccgttaca taaaacttat
    13621 tgaattatat aaatacttaa aaatctaata tattaaatta atgatgttca taaatatcaa
    13681 ctatactcca acatatattt aagtttttag tcttaaaaaa cagatgcaat aaatttaatt
    13741 attaacaaat acacgtattc tttaattttg tatacattat ataccatgct ttacaaatat
    13801 aagagtatta tagctatgaa tttttaattt tttatagtaa atttaattca atttaaatct
    13861 ttcaatctta atcattataa gttataagtt ttcataagta tttacatgtt tcaagtttta
    13921 aacatttacc tataaacgct actttataga tgtcacttca aatccagtga cctcatactt
    13981 tcatatgagc gtagactatt tcttcatctt cagcattacc tgctaagagc aacccgtttc
    14041 cactatcaat cgcttatagt gtactctctc tcgagatagt cgtttgacct tcctatttct
    14101 aggcttggcg accaaatgtc catttttaag tacttaggct ctcaccatat accatcctca
    14161 ctattgtttc tggttttcac cacattcata aaagtttctt tctatctttt attgtagttg
    14221 caaggcttta ggatttactg gttttaaagt tgtgtcctac atagatttct ctatgtacgg
    14281 ggccaaaagt acaatttatt taacatactt tgctttaccc cctgtaaata atattattta
    14341 ctctttcact gtttttgtta ttaaattaat taaatatcaa ttaatctaag cataaaataa
    14401 ttatttaatt taaactcaaa atatttatga atattttata atataattct cataagacag
    14461 aaaaacttaa taagctatgt atctcagttg taccaatgta ctctccttta ctatatttgt
    14521 atctgcaaca taaaatatac aagtttctat ctatttatag atatatatat ctataagcaa
    14581 aatagtaata ttatttttat agtaaaaatt ttattcatat tactatttat aatttttata
    14641 gagcaatttt agtgccaata tttgcataca tttgtatagt ataaaatttt tatgttctca
    14701 ttgataaaat tttacttatt tcaagcgttc tattagattt tatcatctaa attttaggtt
    14761 ttatttttat aaattaattg tatttacata aaaaaaaaga cctaaaaaca aatttttaac
    14821 ggtcttttct caatttttta ttttcatttc taaaatttat aataaatagt aagaacacta
    14881 taaattcttt tatataaaat tcttagtttg tggatgataa attagtgaat taaaatacta
    14941 ctttactgat tttagtttga caatatcact ccaattttta ctagtggcta actctactaa
    15001 atttaagtct cttcttattt cagctatatc ctcttttata gaattagtgt caccttttat
    15061 atatgctatg ttatgttcta tattatcatg agtagcttta tttatttcag aattatgtaa
    15121 taaacttcct aaaatattat tctgttctat ctgtatctct ttcattgatt tatcttcaca
    15181 ttctagacta tcaatcttaa tttcaattcc atataatttt tcatttgcta tggatacctc
    15241 gtccttaatt ccattcatat cttcattaat gttatttatt ttattttgca taaagtttac
    15301 ttctgattta acttcggaaa catcttcttt cattacagtt atttcttgtc tcacttctga
    15361 catgtctttt ttcattacat ttatctcttg ttttacctct gatgtatctt ctttcattac
    15421 ggtcatttct tgtcttactt cggacatatc ttctttcatt atatttatct cttgtcttac
    15481 ttcggacata tcttctttta atacatttat ctcctgtttt acttccgaca tatcttcttt
    15541 cattacagtc atttcttgtc ttacttccga catatcctct ttcattgtat ttatctcttg
    15601 tcttacctcg gacatatcct ctttcattat atttatctct tgtcttacct cggacatatc
    15661 ttctttcatt acaatcattt cctgttttac ttctgacata tctcctttta atacatttat
    15721 ttcctgtttt acttccgaca tatcttcttt cattacagtc atttcttgtt tcatttccga
    15781 catatcttct tttaatacat ttatttcctg ttttacttcc gacatgtctt ctttcattac
    15841 agtcatttct tgttttactt ccgacatatc ttcttttaac acatttattt cttgttttac
    15901 ttccgacata tcatttttta tgctaactac atcttcattt atagtatata ataactctaa
    15961 aatcttctct tgcacttgca tcaccatccc tattaattat tataacattt tacacaaatg
    16021 ctatacaatg ttaacatata tatcagaatt attaaaattt taattaaaca aaattgattc
    16081 actttattac ttcaaaacta attaatatct aaaataacta caaataaaca aaaataaggt
    16141 caacaacaaa aaaggcttat ctctttgaga tagcctttct tatttttatt taaaactttg
    16201 ttttttataa aataatctat acattcagct ctgaacatga aatttttctt ccaagtgctt
    16261 ttggtttaca aactgatata caaagtccac aatatctaca ctcttcttca ttcaattcca
    16321 tcttatcatt caattttctc gcttgatatg cacaaactct ctcgcacatc ttacatttag
    16381 tacatttttc ttcatcataa gtaaactcaa agctaagtct ttcattaaca tctcccatat
    16441 gattatgtac tataccacaa gcattttcta tagtattata tcctaatcta ttaagattag
    16501 attttaaatc atcatgtatt ttagatatta cttgtgcacc ttttaaaatt actactgaac
    16561 atataccaac aaagtcagca cctgccataa tcatttctaa ggcatcatct ccacttacac
    16621 atccacctaa gccaattatt ggtatattaa cttgtttttt tatttcatat attctctgta
    16681 aagttattgg cttgatagtt tctccactta aatatcctat tccatttcca cctaataaag
    16741 gttgccctgt ttctatgtct attctaaatg ctggtcctac agagtcacaa gcagttattg
    16801 catctgctcc tgcttcttct aattttttag caaaatcgcc tatctcatct atcataggag
    16861 gaagtttaac tattacaggt atatttactc tttcctttgc atctttaagc attggtatca
    16921 aatctctata gtcataagat actaattcaa taaagtcagc tcctgcattt gcaactttct
    16981 ctactaattc gctactttct tcaattgtat gacctattga agctatacag acagtcccat
    17041 ctcttttcat ttgtggtatt tcaaaatcta tccattgctc tggctcaaaa tctgtccatt
    17101 tttcattatt taaaagagca ttagctgtat ttctaaccat atgtggtgct ggatttatag
    17161 ctctttcttt tcttatagtc ttagtcacaa ctgcccctgc tcctgcatca cttaatatct
    17221 tgcatccagc tgcactatat gttaatggtc ctgaacctat tataagtggt gattttaatt
    17281 ctttacctaa aaaattatac attatctgct tccccttttc atatatattt acattcgtta
    17341 aaatttccaa aattcacaag caacttcttt catttcttta acaatagctt ttttatctaa
    17401 atcaactaac tgtttttctt ttaaaatatg tctaccatct atgtatacat ttgatataaa
    17461 ttctttttta ccctgaacta ctatctggtc aaatatatta tcaagagtca caggagtttt
    17521 aaattcatct tccataacta ttatatcagc cttattacca actgctattt taccagaatt
    17581 ttgaagtcct aatacataag caccatgctc tgttgccatt ctaaatacta aatttgctgg
    17641 cattactgat gcatcttctt caactgattt atgcattaaa aatgcacctc tcataacttc
    17701 aaaaaaatca tttatatatc catcagtacc cagtgccact tttatgcctt ttttaatcat
    17761 ttttggtact ggagaaaaac ctccacctac ttcacagtta ctaagaggca tatgaaccac
    17821 ttttacgcct ttttctttta atatatctat ttcttcatca tttactttta cacactgaga
    17881 tgctaataca gtttcatcca atatatctaa atcattatag tagtcaactg cttttttgcc
    17941 aaagtgtttt tcagcatagt ttggctcata tatactctca cataaatgaa attgcattgg
    18001 tgcatttaat ttttttgcat cttctttagc tttcttaata aatctatcag aacatgtgaa
    18061 gcttgtatgt gtacacatta ttccatttat taatttacta ttttctctac tccactttat
    18121 taaattagaa ttttcatcta aacatctaag tccattttca aagcttattc tttcacaact
    18181 ttctaaggat aaaatcgctt tcatgcctat ttcttctagt atttttcctt gctcaattaa
    18241 agttccttct tctgtatttg gagcttctag ggtatcacaa aaagctacca caccagattc
    18301 tataagttct attgctgatg ctttagttgt tgccttcact tcttttaatc caattctatt
    18361 ttctataaat ggccaccaat agtcatttaa aaaaccttca aagtcagtaa aatgtacatt
    18421 tgccggtatt cccctagaaa gaactccata ttgatgcata tgaccattga cgaatcctgg
    18481 cattattata gcatctgatt tatctattat ttcttcaata tttttatatt ttatttcaac
    18541 ttcttcattt ggcaatatat cttttataat gtcattttct actacaacag cagaatttgt
    18601 atatatttca tcagcagaag atattaagta tttactttta atagcaatca tttatttacc
    18661 tccctgattt aattttttca tggccatata aactttctca gaagttatag gaagttctct
    18721 tatacgaact cctgtggcat tgtatattgc atttgctatt gctggtgcag gtgtatgaat
    18781 aactatttct cctaaagatt tagctccata tggacctgtt ggctcataat tatctacaaa
    18841 atcaacaatt atgtttccta tatctttttt tgttggaact ttgtattgta atagattaga
    18901 agtttgaagc tttccatcag aaccatgtct agggtcttca tacattgcaa gccctatacc
    18961 ttgagttaca ccaccttcaa cttgtattct agcaagtgca ggattcataa ctgtaccaca
    19021 atctgtagaa caagcataat ttattacttt aaactcccct gttgttttat ctaactctat
    19081 ttcagcaaat cctgctaaga atggtttagc actctcttgt ataccataag attcagatga
    19141 atataaaact tcttgatttc caccaccaac agattctttt cctaattcac ttaacaaaac
    19201 aaacttctct acatcttcac tataacaaac tctgtcttca tatagtatta aatcatctat
    19261 tggtaaatcg agtttcttct gtgctacttt taatatcttt tgttttaaac tttcagcaga
    19321 ttttattgta gcatttccag ttacataagt agtacaagaa gcgtatgcac cagtatcata
    19381 tggacacata tctgtatctc ctgtataaac ggaaattcta tcaatagatg tattcaatgc
    19441 ttttgcagct atttgtgcaa gtattgtgtc agaaccagtt cctaagtctg aagacccaga
    19501 aaacaactta taagttccat cttcatccat cctcatattt actattgcca tgtctatgtt
    19561 ggctatacca gaaccatgag ttcccacaga cattccaaca gccctcacct tattgtttcc
    19621 aatatcccta acagggtact tttcatccca tccaataagt tttttacctc taattataca
    19681 ttcatcaagt gcacaacttc ttattggaaa attcattatt ccgccttcag tttgtttttt
    19741 tataatattc tttaacttta tttctgttgg gtccatatta agtttatgcg ctaattcatc
    19801 aattgcacaa tcaagtgcaa atgtaccttg tgttgctcca tatcctctta atgctcctcc
    19861 tggaactaaa ttagtatata cagttttccc atcaaatttt attgcaggta cattattata
    19921 tgttggaagt acattatgac ctgattcaga gcaaactgaa ggtccattat cgccataagc
    19981 gcctgtattg ttcaatgctt tcatatctat agcttttatg tttccttctt tatctgcccc
    20041 aatttttata tcaaaaaaca tctgatgtct agtattagtc attgcaaaag tttcttctct
    20101 agtataaatt agttttgctg gtctttttgt catccaagtt acaaatgatg catatatctc
    20161 tgttacagct atgttttttc caccaaaacc tccacctatt cttggtttta ttactctcac
    20221 ttttgaaaga ggtattccca gtgctttaga aacctgtctt ctcatatgat aagctgattg
    20281 gtttgcagaa gttactacta atctgccatt cgtatctata tacgtataag ctctatgagt
    20341 ttccatcata caatgggctt gtgattgagt catataagaa tgttctacta ttacatcact
    20401 ttctttaaac tctttttcta catccccttt acccattttt tctctcgata caatattttt
    20461 tgtagcatcc aatccaaaat caaatggaca aaacaaatca tcttcttcat ggattaaaat
    20521 tttatttcct tccgattctc ttgcatccaa tataggagtc attacttcat attcaacttt
    20581 tataagtttc atagctttaa tagcagccct ttcatcttca gcggctatta tagcaacttc
    20641 atctcctaca tatctaacta cgtcttcaag tattaattgg tcatgaggtg atgcttctgg
    20701 atatgactct ccaaccattg aatatctata atttggaaca tctttgtaag tgaatatgtt
    20761 tactacacct tttaccttta atgcattttt tatatctatg ttttttatct tcgcaaaagc
    20821 atgtggactt ctaagaagct taattgttaa aacatcttta tgaaaaatta aatcttctgt
    20881 atatattggt tttccagtaa caatggcttc actatctatt tttcttacct ctttatttac
    20941 catcacactc acctccaata ctattataca ttctcactac taaggctttt gtcatatctt
    21001 ttctgtattc tttacttcct cttatattac ttccaaatga aagttcttca cttgatactt
    21061 caccagcttt ttctatatca ttttctaaac ttaatatttc acttgcttta taggcaattt
    21121 ttgctcttct tggtctagcg cctatcgcaa ttttataaat acttccttct tttaacattg
    21181 ctccatttaa tactgcaaaa tcacctgtac attttcttat agaatcaaat acacctatag
    21241 catctttttt aggtaatata acttctatta atatatcttt ttcaagctca ttttctaaaa
    21301 aatcagctaa gttcataacc ccttttttat ataacttaac ctttgcatct accactagta
    21361 atgaaggtat taaatctgaa aatccatact tagcaaatac gctagctcct actctagctc
    21421 cacttctaaa ttgaactcct actatattag aaacagcgtt tgaaattacc ccattacagt
    21481 aatttttaat aaccttattt aattctaaag ttcttaaact tgtatctgct ccaattaata
    21541 tgctatcatc agtttcattt atataatcta aagctaagtc ttttaaatct attgctgaac
    21601 caatattttt actacctagt tttaaaaatc cacatcctcc aagtattatg ttgttttttc
    21661 ttgatattag cagttcataa gcttcatcta aactttttgg aactacatat tcctttatag
    21721 ttatcatact ctctccccat atcaacttaa ttttcactta aaagtctaag tgtttaaata
    21781 tttatgtatt gctcttaatt gacctttata tcctgtacat ctacaaaggt taccatttac
    21841 ataatctata acttcttctt ctgttggatt ttgaagctct cttttcattg ccaagaccat
    21901 cattataaat ccaggagcac aaaatccaca ctggtcagcc ccttcgtctg caagaaaatc
    21961 tccaaacttc tttgcttcat ccaagacacc ctcaagtgtt gtaatatgct gaccttctac
    22021 tctagcagta agataattac atgaaagcac ggccttgtca tttaccatca ctgtacataa
    22081 cccacatgag cctgtatcac accctttttt aacacttaca tatccatttt ctcttaatgt
    22141 atctgctaaa aaatcatctg gtcttatact taattctttt tctttattat ttatggtaca
    22201 tttgataatc aaataaatca cctcaaaact catattttta agctaaagtt ttactatact
    22261 tttttatgaa taaattacat ttattaataa aggctattcc atttatgacc ttccattcta
    22321 ttttttatag ttcctcttat acaaagtctc tcagctgtat cttgagcatc ttttaatgct
    22381 ttctcttcat tagctgtcaa tatttttgaa tcttccatta ttatatttcc atctactata
    22441 acactctcta tatttttcat actagaagaa tatactaatg tagataccgg attatgcata
    22501 ggtatcgctt ttggtgaaag cattggatta aatattagta agtctgcttt tttacctatc
    22561 tccaatgaac ctatctcatc ttccattcca atagctcttg ctccatctat agttgccaac
    22621 tcaagaactt tttctgccga cattgctaat gggtcacact tattaacttt atgttgaagt
    22681 gctgttaatt tcataagttc aagcatatct tgagagttat tactagcggc tccatctact
    22741 cctaaactaa ctgttattcc ttttttaagc atttctggca ctggtgcaac acctgaagat
    22801 aagtacatat tacttgctgt attatgagac actttcatat cgtatttttt agtaagttcc
    22861 atatcttttt cagttagata cacacaatgt accataagca catttggtcc aagtattcct
    22921 aatttttcta aaacatctat gtcatattgc ccatgcaatt cttttgctgc ttctctatca
    22981 aaaggagtct ctgatatatg tactgtaaat aaagcatcat catattcttt tactactctc
    23041 catagcattt caagcatttc ttgagaattt gaccatattg ctgcaggagc tactcctatt
    23101 ttgattcttc cattttctgt attatggtgt ttttcaaaca atcttcttac atctttttca
    23161 accgtttcta catcttgcat tattccagga tgaactccaa attgagctcc tgtattcata
    23221 catcctcttc caagtattcc tcttattcct aattctttat aagcatctat tattccatca
    23281 caaagacctg gcttactatg aggatacatg tagtcaacca ttgttgttat accacttcta
    23341 agtccttcaa tacatccaag cattgcagca tcataagtat ctttgggctc taaatagtta
    23401 gctgctggaa atgtcatagt ttctaaccag tctttaagta ccatatcatc tcccaatcct
    23461 tttaataaag tttggaataa atgattatgt gtatttataa aacctgggaa taaaacttta
    23521 cctttagcat ctataatttt tttaacatca gtatatttac tttctatctc tttagaattt
    23581 ccaatatcag caatcttgtt atcttttact actaatgccc catcaaaaat aacttctctc
    23641 tctttattca cagttactat tatggcattc ttaataagta tatccatcat tcttatttcc
    23701 ccccgcatta tttagtaatt tttcttttaa tatattgacc tgttggatgt tctttaacat
    23761 tacaactttg tactacatga tttcctctca aaaatacatc ttcaacttta catttaacct
    23821 taaatccttc atatggagta taatctacat tttgtttttg agttttataa ctaattgttt
    23881 cttctttatt gatatttaaa atgactatat ctgcatcact tcctacagct atctcacctt
    23941 ttttaggata cattccaaat atttttgcag cattcgtaga agtaacttcc acaaacttat
    24001 ttacacttat tctattttct aagaccccat atgtatataa aagtgctaac ctatgttcaa
    24061 caccaggtgc tccatttggt atcttactga aatcatcaat tcccaagtct ttttgcccct
    24121 taaaattaaa tgaacagtgg tctgtgccaa ctgtttgaat atctccacta gacaatcctt
    24181 cccaaaggta atttatgtct tctttttttc ttaaaggagg agacattaca tacttagcac
    24241 cctcaaattt atccttatta tataaattgt cttctaataa tagatactgt gggcatgttt
    24301 ctactatcat atctatattt ttttctctag ctatttttac agtttcaagt gactccctac
    24361 aacttaagtg gactacatag gattttgaat tagataattt agttatatca gcaagtcttg
    24421 aaacagactc tttctcaact atgttaggtc ttgtaagtgg atgatatttt ggctccaaat
    24481 taccattttg tatattttct tctatcaata catctagtaa atccccattt tcacaatgaa
    24541 atccaactat acaacctaaa tcccttgctt tctttaaaac cctgtatatt gttccatcat
    24601 ctactttcat gccatcatat gccatataca tcttaaaaga tactatccca tctgaaataa
    24661 gtttttccat atgattaaat gtatctttat ttaaacatgt aattgtcata tgaaaaccat
    24721 aatcacaata acaatttcca cttgcttttt tatgatatgc ttctacacct tgcagtagat
    24781 tttccccctc attggcttct gcaaaatcta gtattgtagt agttcctcca gctatagctg
    24841 ctcttgttcc tgtttcaaaa ttatctgcag ttgtaataga acctgcattc atatcaaaat
    24901 gagtatgtgt gtctattcca ccaggaatta caattttacc tgtagcatca ataaccttat
    24961 caccatttat ttctaagtta tttcctattt caactatctt ttcatcttct atccttaaat
    25021 cacttatata agtcttatca gaggtaatta tagttccacc tcttagtatt gttcccatat
    25081 atacctccta acttttaagc tttaaagtat tttctaagta ttgtaaaact ttatttaaaa
    25141 ttgtattttc taaaggtgct atattcagca cctctagact atatttaaat aatttattgt
    25201 gaactaaata ttattttccg tatacagatt ttaatattcc atagtaacct tctgttccta
    25261 taaataactg ttcttgctct atatactcat ctattgtgtg agcaagattt tccttagaag
    25321 gaccaaatcc tatagttttt attccagctt cacctgcata gtgacttcca ttcgtacaga
    25381 atgagtattg agttatttct gaatctattc cagcttcttt taatccctta tacgctgctt
    25441 gaacaaattc atcttcttcg tcatataacc aacctgggaa gaatctttca ctttctatag
    25501 tatttcctgt atagcaatca gctttttcaa ccgcataaga aacttttgca tttaattctg
    25561 ggtcttcttt catcatttca tctaataaag cttgtattgg agctaatacg ccttctcttg
    25621 tttctccaac taataatctt ctatcaaaag tagctttgca ataatctggc actactgatg
    25681 ctcctggata tggagaagat tttatatctg ttaaaactaa tattccatca cctaaaactg
    25741 gatgagttgg aggtactaat tgttgtatct tttggattac attagccatt ttataaactg
    25801 catttacacc tttttctgga ttagcagagt gagctggttt accaaaagtt tctactacta
    25861 tttctcctct acctctctga ccaatcttta agtttaactc tgaagactca cctattacaa
    25921 catagtcagg ttgaacagcc ttacttatct ctctagccga aacaccttca aatatttctt
    25981 catgaacaac acctgctaca tatagttctc cagcaaaatc tctattagtg tctttagcaa
    26041 aatacgctac agcagacatc attgcagtat attgaccttt catgtcagaa gttcctctac
    26101 catatatctt tccatcaact atttttcctt caaaaggagg aacactccat ttacttgcat
    26161 ctggaactgg aactgtatct atatgtccat caaataatat tttcttacct ggcttgttac
    26221 cttttataca tcctactata tttccatatc tatctcttga ccaactatca aaacctaatt
    26281 tttcaaaaga ctcttctatt gcttttacaa caccttcttc atttccagaa gaactaggat
    26341 tttgaattaa tttttggcat atttcagtta cttcttgttt tctttgttcg tttaacattt
    26401 cattatcccc ctagattttt tataatgtat gtattttata tacttatata ttttctaaat
    26461 tttagaactt atatatcttc taaatatgta aaccaatatc taataattgc attttagtaa
    26521 ttccttatat acttggatat tctccatccc aaactatact tctatatttg tcagggtcag
    26581 tatctccttc tgtgcttatt aaaagtattc ttgaattttc atctaatttt aaatcttttc
    26641 ttaaatctgc taaatcttct ctttccatag ctgctactaa aagaccagtt gtaactgctc
    26701 cagattctcc agaaattacc ttttcatcac catttaaagg attacctaat gttctcatac
    26761 ctttagcaga aacccagtct ggtgctgaaa caaatgctgc tgcatgattt tttaatactt
    26821 caaatcctat agtatttggc tctccacaag caagccctgc cattatagtt ggcatatctc
    26881 ctccaacaaa tcttggtttt ccatctccag cttctgctga tttatagtaa caatcagctt
    26941 catcagcctc tactactact gttattgggc attcatcata tattgaagca acataccctt
    27001 gaactgcacc agcaagtgaa ccaactcctg cttgaacaaa tacgtgtgtt ggtctatcta
    27061 ctccatattc ttttaattgc tctatagctt cttgagccat agttccatat ccttgcatta
    27121 tccatgctgg tatttcttca tatccgtccc atgctgtatc ttgaaccatt actccatggt
    27181 catcagcttc tgcataatca ttagctaatc ttactgcatc atcataattt aagtctgtta
    27241 tactagcatc tgcaccttct cctttaattt tatttaatct aaattcagaa gaaccttttg
    27301 gcattaatac aacagatttt tgacctaatt tattagctgt ccaagcaact cctctaccgt
    27361 gatttccatc tgtagctgta aagaaagtta tttctcctaa tttttctttt atttctttcg
    27421 aagtcaattt gtcataccct aactcagata tatctgtatc taatctttga gctaagtatc
    27481 tacccataga ataagaacca cctaatactt taaatgcatt taatccaaat ctataagatt
    27541 catcttttac atatactcct gcaacaccta atttttttgc taaaccttct aggtttgcta
    27601 atggagtttc tttatattga ggaaagcttt tgtgaaaatt tctaacctta gttatttctt
    27661 cttcatttaa aaatttgata caattttcct tatcgccctt tggcaaatta tttactttcc
    27721 atttaatttc ttttaacatc taaaatacct ccaaattatt gttaaatttt tatactttaa
    27781 tatataagca attaacatgc caatactaaa tatatactag atatttttcc atgactcttt
    27841 agtatagaaa ttgcaatgct tttattattt tttcttttct atctttagtt catacaatgt
    27901 atgtagaatt taataactaa aa
//
LOCUS       DAEHWM010000044        27802 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.045, whole genome shotgun sequence.
ACCESSION   DAEHWM010000044 DAEHWM010000000
VERSION     DAEHWM010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27802)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27802)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27802
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.045"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(128..1318)
                     /locus_tag="KNP36_002015"
     CDS             complement(128..1318)
                     /locus_tag="KNP36_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBF0873888.1"
                     /translation="MNFNQKRIAASIMATAIIMPTMGNLAYANESEVESVSIESRTIT
                     GNAVNFRKGPGTNHESMGKLYKGDKVEYVGKEGSWVKVKYNGNTGYVHGNYVAINSLG
                     SSNESSDTSVKSTKVVTAKGLNFRTGPSTSSSKISTLGYGTEVGYISESNGWSKISSN
                     GRVGYVSSKYLGTSVNDSTNENAENSSNDLVKGTKVVTAKSLNVRTGPGTSHSKIATL
                     SYGTEVGSISESGGWTKVSYGNQTGYVSSQYLAEKGSVDTSIPSYSTNSPSQGADSVI
                     SFAKTLLGKPYVWGAEGPNSFDCSGFTQYVMKKSVGVSIPRVSRDQSKYGTYVNRGDL
                     RSGDLVFFDTQGSNNGSVSHVGIYIGNGDMIHASSGSSKKVTISNINSSYYSSRYVNA
                     RRVL"
     gene            complement(1578..2009)
                     /gene="dut"
                     /locus_tag="KNP36_002016"
     CDS             complement(1578..2009)
                     /gene="dut"
                     /locus_tag="KNP36_002016"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HBF0873889.1"
                     /translation="MYNLKVKKLNDDAIIPNFAHKGDAGMDLYSIEEVVIPPGETKLI
                     KTGICIELPTMTEAQVRPRSGLALKHSVTVLNTPGTIDEGYRGELKIILINHGKNDFK
                     VEKHMKIAQMIVKPIYDINIEEVKELSDSERGKGGFGSTGF"
     gene            2122..4350
                     /locus_tag="KNP36_002017"
     CDS             2122..4350
                     /locus_tag="KNP36_002017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IA DNA topoisomerase"
                     /protein_id="HBF0873890.1"
                     /translation="MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLV
                     SLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVI
                     NATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAA
                     GYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYY
                     EIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAP
                     KLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASK
                     ASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDA
                     IKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVN
                     KDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATR
                     ADVLKKISQVGYVKKKGKSYSITDLGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGK
                     YTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNT
                     EKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKND
                     KYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEF
                     DN"
     gene            complement(4461..4946)
                     /locus_tag="KNP36_002018"
     CDS             complement(4461..4946)
                     /locus_tag="KNP36_002018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0873891.1"
                     /translation="MDNNNILKIADSFLDFLFVLENNIFKESDLLKKFQNNSDIMKAY
                     FEECPMAPSHAKVILYLMTSNSSSISQIASNLGILKSNMTPIIDRLVEHGLVNKFPDP
                     KDRRILRVELTDKAFKLFDAVKAILKESLVKKLSNLSEEELTLLDEHTLKLSEIVKKL
                     G"
     gene            5198..6421
                     /locus_tag="KNP36_002019"
     CDS             5198..6421
                     /locus_tag="KNP36_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HBF0873892.1"
                     /translation="MKRYLIVFLMCSSLFLVGCGKTEESEPEKPIAVSVQKAIGGEIE
                     NTNSFSGTTKVKDETAVTAQTVGTVQEVYVKLGQNVRKGDELLSISSPELENSVKQSK
                     ASLDLAKASYSSATGGSLEAQVNQAKTALDNAKIQYEESQRNYDNNKILYEQEVISLD
                     QFKKIEFSLEQTKQQLDSAQRAYDTATSKSIPQAKALAKKQLDQAQVSYNLAMSNLDK
                     LTLTSPVDGTITAKNFDSKEMITQSQPAFIISNPSILEVDLNVAESDIGKFKKDGNVD
                     VIIEDQRILGKIDYVPSVVDPQTSLYPVKVLVNNTNNKFKAGMSAQVNLSVEKENGAV
                     TVPKKAIFEENGKKYVYIATKDNIAKKHLVQTGIVTEDKIEIKSGVSDKDTVIIGGIS
                     LISDGTKIFPVEKEK"
     gene            6425..9559
                     /locus_tag="KNP36_002020"
     CDS             6425..9559
                     /locus_tag="KNP36_002020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter permease subunit"
                     /protein_id="HBF0873893.1"
                     /translation="MNLTQTSVKRPLTIIMVFLVLIVFGGIGYKKMSINLMPDIEIPV
                     VMVMTTWTGAGPQDVDEQVSQKVDESLSAVSNVKSTISSSQESVSMVVAQFEFGTNLD
                     EIMNDVRSKVDALQTSLPDDAAKPTVLKLDMNAQAIGQLVISGGNENSSQALRKYAED
                     VIQPKIESIDGVTSADLKGGKKAQVNVIADPAVLSNYGVSLSTIKGVLSSSNKTFPYG
                     SITQGEDKIVLRAIDKLESLDDIKQIQIPVKGGNTVRLDNLCSVDYGYADKDSIYRYN
                     GKDSLVIDISKQQDANTVKVMQSAYKYVDELNKENPQFKIKIANDTSSYISESINSVM
                     SNLLISAVIAFIVIFAFLKSVRASLVVAVAIPISIIGAIAILYFTGESLNLITASSLV
                     ISVGMVVDNATVVIENIFKYRKSGRLSLDDCAIEGTRTVTNAILASTLTTIAIFLPIM
                     FTEGIAKITFGALGKTLIASLAFSFIGAITLVPSVFAKLSRGKNSQKMQEKDSPIFDK
                     VSEAYKKLLSVCLRHQRLVVISSLLIFVASLFGMGFIGMDFMPAADKGELSISIELPK
                     GLSLESNDYYVSMTEKKVSDIPEIKTLITTLTSDSNNSKASIAIELESQKNRKRTTDE
                     IEKEIIDRVATVPDCKINVSQNSSVMGGAGGADFTLEMKGPDLDVLKILGKEAEKEFS
                     SIKGFRNVETSLTDTTQEAQFTIDKHKAQEYGVNTAEIAGMLRTAINGDSVTTATIDD
                     YKVDVNLKFKADTIDSLEDIKQLKVNSATGKEVPLGAFSDIKMADGLQSISRTDGDFS
                     VNITATLDNLDAGTATKLALEKTNKMVIPKDYSIGVGGETEMMNESMASLGFSMVIAI
                     ALVYMVMVAQFESFSKPFIIMFCVPFAFVGVVLSLLVSGQSLSTVGMLGIILLIGIVV
                     NNGIVLIDYIEQLRKTNRNNDLIGLVSIGCAARLRPVLMTTATTILGMLPTALSLGEG
                     GETMQPLAIVIMGGLTVSTLITLVLIPTIYLIFDKWENKFSDKMPKIFGKITDKIGSI
                     KRKIIKKPKLKAKV"
     gene            9593..10891
                     /locus_tag="KNP36_002021"
     CDS             9593..10891
                     /locus_tag="KNP36_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TolC family protein"
                     /protein_id="HBF0873894.1"
                     /translation="MSKIVAIGCGVGIITANLIPVYADNNTSSINKVDNSILSDSNKR
                     TSEKEILTAREAVSAALKNSEKLKMKSEEIKMLKEKLEVQDEFDSFTGSDNSFPYDQI
                     GLLKNQSEQAKGFMEDQIANDITNKFNDLVSRENELDKIKNNLEIKTKEIKDMKLKKD
                     LGLVTSLETESAELELQTLQNTQKAKLQELKNNQDYFKLLTNIDLNNYQLDKEYRFES
                     FRVGGSVDSYMEGKVNEYLKYDQLILERTEESFNDKDENKADLPDRPNLTRPVAPTKP
                     EQGNLTDDEYKVLTDKYEKDYKRYEKEVEAYNLERQTYAAGLTTYANYLQQKFNTENG
                     LVTLEDSKKALKKGLIDSYAQLLALEDTIQITKKQLDLSEKQLKNTKLRYDLGLITLT
                     DYKKQVVSNEDAKNSYDTLIVNYNSLKNGIEKPWILNTGK"
     gene            complement(11180..11425)
                     /locus_tag="KNP36_002022"
     CDS             complement(11180..11425)
                     /locus_tag="KNP36_002022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0873895.1"
                     /translation="MTKCPKCGKEVSSRPGSICPRCGFKVADESLKIRCPEPSCRALV
                     SRKLDYCPKCGCKLRGYNISEFVNMVRCKIDETFDKK"
     gene            complement(11639..14266)
                     /locus_tag="KNP36_002023"
     CDS             complement(11639..14266)
                     /locus_tag="KNP36_002023"
                     /EC_number="2.7.9.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBF0873896.1"
                     /translation="METKYVYSFGEGSKDMKSLLGGKGANLAEMTKIGLPVPPGFTIT
                     TEACNDYYVNNESIRAEIIKEIEEHLATLEKDLNKTLGCNKNPLLVSVRSGAVFSMPG
                     MMDTILNLGLNDNSVVGLAEATQNERFAYDSYRRFIQMFSDVAMEVPKYKFENVLDRV
                     KEAKGYTVDTELTTDDLKEIVKEFKAIYKKEIKNDFPQDPKEQLMLAIEAVFRSWNNP
                     RAIVYRKLNDIAHNLGTAVNIQSMVFGNMGETSGTGVAFTRNPATGENKLFGEFLMNA
                     QGEDVVAGIRTPQNISTLADVMPAVFDEFVKITHILEGHYKDMQDIEFTIENERLYIL
                     QTRNGKRTAAAAINVAVDLVEAGIIDEKEAIMRIEPNQLDQLLHPKFEDKALKEAKVI
                     AKGLPASPGAASGKVYFNADDVVKANEKGEKVVLVRLETSPEDIEGMVKAEGILTARG
                     GMTSHAAVVARGMGKCCVAGCGEIKVDEFNKEIRALDDVVIKEGEYISIDGSTGNVYL
                     GDVKKTEVSLTGNFEKLMNWVDKHKCMMVRTNADNPRDARAAIEFGAEGIGLCRTEHM
                     FFDEARLPAVREMILSNTVEQREKALEKILPMQREDFVELFKVMDGKPVNIRLLDPPL
                     HEFLPHDDETIEELSKSMGIKVSDIKKRIVDLDEFNPMLGHRGCRLAITYPEICVMQS
                     KAIIQGAIEAIKAGVKVSPEIMVPLVGEVNELKIIRKMIVETVDAIIKEEGIEVPYTV
                     GTMIEIPRACLTADEIAQEADFFSFGTNDLTQMAFGYSRDDAGKFLGQYVDEEILEKD
                     PFQVLDQNGVGKLVKMGAKLGREVKPELKLGICGEHGGEPSSVEFCYSVGLNYVSCSP
                     FRVPIARLAAAQASIKNPR"
     gene            complement(14327..15169)
                     /locus_tag="KNP36_002024"
     CDS             complement(14327..15169)
                     /locus_tag="KNP36_002024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="kinase/pyrophosphorylase"
                     /protein_id="HBF0873897.1"
                     /translation="MLVKNLIIYAVSDSVGETAQQVAKACMSQFYVNETYEIKRFPYM
                     INKGVLLETLENAKAENALIVYTLVDEELCSIVERYCEREGLSCIDLMTDILREISKR
                     TGRKPKREAGIIRKLDESYFKRVEAIEFAVKYDDGKDPRGVLQADIILVGISRTSKTP
                     LSMYLANKNIKVANVPLVPEIPIPKEVFEIDTKKIIGLTNSPEKLNEIRTQRLKALGL
                     SSKANYANLERILQELDYSEEIMKRIGCPVINVSNKAIEETAGIILDIMKENGLKIYK
                     EIEI"
     gene            complement(15176..15814)
                     /locus_tag="KNP36_002025"
     CDS             complement(15176..15814)
                     /locus_tag="KNP36_002025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0873898.1"
                     /translation="MIIIQLNERQLKIIDIVKENEPITSESIASSLNVTRATLRSDLA
                     ILTMTGILDARPKVGYFYSGVSEINLIGKSVKEKTVEDIMSMPVLAKKDESIYDVIVT
                     MFLSDVGSIVIIDENEELCGVVSRKDLLKATIGGSDINKMPIGMIMTRTPNVVTLTKG
                     ASVLLASRKIIEHEVDSIPIVEYKGEDKNHMRVVGRISKTNITKLFLEIVDN"
     gene            complement(16250..17542)
                     /locus_tag="KNP36_002026"
     CDS             complement(16250..17542)
                     /locus_tag="KNP36_002026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HBF0873899.1"
                     /translation="MLDLNRKLAKLEEEGKKIKVALIGAGHMGNGMVSQMANMKGIEA
                     SIVVDIDLELAHKAFTDAGIDEEIIDNVTNEKDAEIKLQEGKVLTCNDFLVACKTKSI
                     DVVIDATGGIAIGAEIALNSILNKKHIVMLNAETDCVVGPILKKLADDAGVIFTGSAG
                     DEPGAVMELFDFADAMGFEVRVIGKGKNNKLDLDCNPDTVREEAERKGASPHMIASFK
                     EGTKTMVEMALMCNATGFVPDVRGGHGIEATVNEVPKKYALKSEGGVLDNYGVVDFVN
                     GIAPGVFVVVAHKLKAVNDELKYLSMGDGPNYILYRPYHLCSLETPLSAAMAVLDHKA
                     TIVPKAGLVAEVMTIAKKDLKKGEFMDGYGAYTCYGTIEKYDVAKAMNAVPIGLISKK
                     TKVVKDIKKGEVITYDMVEIEKDTTLYHLRQLQEKIFG"
     gene            complement(17579..17935)
                     /locus_tag="KNP36_002027"
     CDS             complement(17579..17935)
                     /locus_tag="KNP36_002027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="HBF0873900.1"
                     /translation="MKYEVKISGIGSLVKELMDESNCLIIYDETINDDDLKDISVIHS
                     IATLKSDVEIGDTLTIGNRDYCIVSVGDIAQKTLREIGHCTIKFDGKCEVNLPGEIHV
                     EIGNPDITIGDLITIS"
     gene            complement(17970..18329)
                     /locus_tag="KNP36_002028"
     CDS             complement(17970..18329)
                     /locus_tag="KNP36_002028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873901.1"
                     /translation="MKLLVILFVAYILNTIFIMKQNKLYFKTLNRAKKKGDIVSTGKK
                     KSYFSKGSIAVISSDSDGFIKFGEILKGRTVMAKFKEIEEIEGLDIYSAEQKFKDEES
                     IVQAIKFIKEKINVSFN"
     gene            complement(18398..20371)
                     /locus_tag="KNP36_002029"
     CDS             complement(18398..20371)
                     /locus_tag="KNP36_002029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBF0873902.1"
                     /translation="MSVTEKIPSIDRKIFKILIMCSKKEFVSINSIANELNVTTRSVR
                     TYIKQLNKDLGNDIAVIKYIKGQGYKLEIKDEQILNKIIDMNRKNVFSLNSKEDRVEF
                     ILNYLIELDGFITLDSLADEMCVGRTTLVNDFQYVEKVLASYNLNLIKKQNTGMKLNG
                     NELDIRLFILNQLYKNSRKDFSNSKYFKGIKKEEIINLEEKLLTLFKKNNFYVTDEML
                     REVINYIVVLVYRVKEEKKVKDYDVKFDLLKSYDEYFIAREIKHIISGMFECTLNDEE
                     IIYLTIPLVSGNAPASECALNSSRISKNIDELMENIFNQIYVDMGIFINEDELRVGLG
                     YHLSFTLNRLLFNIKLKNVLLEEIKQNYILPFKLAQIAGKVIEKKYNLEVSEDEIGYI
                     AIHFSGYLERNSSRFYSIKKIAIICSTGLGTAKLLKIRVEKLIGNNPKIDTLSSFNLR
                     NINLDEYDIVFTTIDLDTSNINTIVLKINTIFDENKLREQLKTVLCLREGNIDTTNST
                     NLLINNLLDEDKFMILNEKTILASLEKMMDHLMDLGCIDEKFRKNIVNREEKSPTVFD
                     KGLLFPHSINEKSDKFLMAVGILEEPIEYANRSIKIILMTMFPCENKIDSDLLVKIYE
                     EVLKIGQDVKLTNKISKCRTFLEFKKVLLKNLI"
     gene            complement(20593..21606)
                     /locus_tag="KNP36_002030"
     CDS             complement(20593..21606)
                     /locus_tag="KNP36_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="HBF0873903.1"
                     /translation="MEENKILKIEKGTSGWGGPLYIKKEGNRNKILSMTAGGIHEVTL
                     KIKELLGCEIVDGFKTGVSDEEVAVVIIDCGGTARCGVYPKKKIPTINVNPVGKTGPL
                     AKFITEEYYVSDVNPNCISVVDGEDMPQKSQENKSENKSSIRKPDNYDEVKSKAQGEY
                     AKKNIILSIGQGAGQVVSKFYDAGRDTIQMVMNNVIPFMAFVSMLMGIILASGLGDWI
                     ARVISPLAGNIGGLLIISVICTLPFLSPILGPGAVIAQVVGTLVGTQIGLGAIPAYLA
                     LPALFAINGQAGCDFVPVGLSLGEAEPETVEYGVPALFYSRLITGPIAVIIAYGVAVF
                     ALR"
     gene            complement(21619..22164)
                     /locus_tag="KNP36_002031"
     CDS             complement(21619..22164)
                     /locus_tag="KNP36_002031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="HBF0873904.1"
                     /translation="MENVITGLSKGAEWFIGLFQKGGEQFIGLVSGTLPTLIVLMVAI
                     NSLIKIIGEERVNNWASKLGKNSFTRYILLPLVSVFFLGNPMCYTFGRFLKEEHKAGF
                     YDAAVSFVHPITGLFPHANAGELFVWLGISAGLTTLGKETTTLALWYFIVGLIVIFIR
                     GIVTEKMYAFLTRKNRATNKA"
     gene            complement(22540..23409)
                     /locus_tag="KNP36_002032"
     CDS             complement(22540..23409)
                     /locus_tag="KNP36_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0873905.1"
                     /translation="MDYLKYFEKAVMYIENNLHENITVNDVAKETGYSYYHLTRLFKS
                     MFGESVGSYIKKRRLVSSTKELLYSDKKVIDIAIGSGFESSEAFSRAFKSIYKVSPIE
                     YRKNRIDVFVGKKKKLELDFMRHLVGNITIKPVIKEIEKIKVIGIKDKVILENNSLPD
                     LWEKFRKVHHIVPNTLPSRRVFGICEAISEIHLVSESMEFNEIIGLEVNSYDVIPNSF
                     VSKTIKEGKYAIFTHTGSLDNLDKTYEYIWGTWFLSSKEELDIRDDFEVYDERFLGPS
                     NVNSQIDIYIPIK"
     gene            complement(23561..24676)
                     /locus_tag="KNP36_002033"
     CDS             complement(23561..24676)
                     /locus_tag="KNP36_002033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="linear amide C-N hydrolase"
                     /protein_id="HBF0873906.1"
                     /translation="METLEVRNIELSGTNYEIGYRLGELVANMPEIIEGQINKSNLVS
                     KKEEKEMIELFDKYCPGLNEELQGFADAIQVNCNQILYYTMTYLKPGCSQVALAPELT
                     ENGHVLFARNFDFSHNMEDFVLCKTKVNGKYAHIGTTIMQFGRGEGMNECGLGVSQSS
                     CGIPVGNSDGLRKPAIVGLQFWAVIRYLLENCKDVDEALEYLKDMPIAYNINLLLADK
                     SGNIALVETLDGKKEVNIINSLESKREYFLHSTNHTHIDKLHKLDPQSMKNSIHRYKL
                     IKEYINKSKKIGEKELMNLLSSKYPNGLSCNYYNDFFGTLKSIVMDLNIGKFNILWGG
                     LENKWESYYLKNDIKSITQRININIEKAPSDFFDFIE"
     gene            complement(24912..26048)
                     /locus_tag="KNP36_002034"
     CDS             complement(24912..26048)
                     /locus_tag="KNP36_002034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0873907.1"
                     /translation="MKERIIQVADSKKEKILGLCQSLYDEPEIALQEYKSAKKISEFL
                     REEGFDVEENLAGMATAFKATKKNGDGPKIAFIAEYDALPGNGHACGHHLIASMGVGA
                     GIALSSILDTYKGEVSIIGTPAEETGDGKPYLIEHGVFDGYDAAMMIHPNSKTCVTPE
                     IIAIGGLDFIFTGKASHAGAKPYNGINALDAVVLLYNNINALRQQLVDGTRIHGIILE
                     AGTAANVIPDMGKVRLEIRAKEQNYFDEVVEKVKNCARGAAIATGCELEFYHFEPTCQ
                     GLNENKVLVDIFTKIMEEFGIYEDEQVMLGSTDMGNLSQIMPCIHPLMKFSENGEELH
                     TKEFLEASINSYAKDRVIDGIKILALTGFNLFENPELLKKMKEE"
     gene            complement(26104..27567)
                     /locus_tag="KNP36_002035"
     CDS             complement(26104..27567)
                     /locus_tag="KNP36_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine:cation symporter family protein"
                     /protein_id="HBF0873908.1"
                     /translation="MTDLVNTINGIVWSPVLVAMCLCIGLYFSLKLKFFQIRDVKEMF
                     TLLLEGDSSHVGISSFQGFATSMAGRIGTGNIAGVAVAIAMGGPGALVWMCIMATLGS
                     ATAFVESTLAQIYKDEHDGQYRGGPPYYFEKGLGWKKCSVLFSIVAIISYTFFMPGTQ
                     SNTLYLAMNQAFGFSKMTIAVASSIALAIIIFGGIKRIGLFAEKVVPIMGGAYLIMTL
                     VIIITNISLVPEAIVTMFKSAFGFGSVFGGMLGSAISWGVKRGIYSNEAGEGSGTYGA
                     AAAEVSHPAKQGLVQAFSVYVDTLLICMATGIMIVITGMYNVTGVCTALPGVEPGPQY
                     VQSAINTLHPQLGDIFIAIVLLLFTFTTLLAFSYMMETNVSYLVTRIKAEKHEKYIIN
                     VCRFMLIACAAMCCFIEPLTSWALGDICIGVLTYINLIAIFTLKKPAIKAYYDYIRQK
                     KMGIKRSDRTFNPIELDIRNAEFWENRYLKEDKHELN"
BASE COUNT         9441 a         4744 c         3440 g        10177 t
ORIGIN      
        1 aataaaaagc aggtatcaat caaatagtaa catgtattat actatacatt actatcaata
       61 ttgtacctgc tttcatatta taagcaataa agaaaaatct atttattagg ttttataata
      121 aaaacaatta taaaactctt cttgcattta catatctact tgaatagtag ctactattta
      181 tattagatat tgttactttt tttgatgaac ctgaagatgc atgtatcata tctccatttc
      241 ctatgtatat tccaacatga cttacagaac cattatttga accttgtgta tcaaagaata
      301 ctaaatctcc acttctaagg tctcctctat ttacatatgt tccatactta ctttggtctc
      361 tagatactct tggtatacta actcctacag attttttcat aacgtactgt gtgaatccag
      421 aacagtcaaa actatttgga ccttctgctc cccatacata tggttttcca agtagtgtct
      481 ttgcaaaact tattacacta tcagctcctt gacttggaga attagtcgaa taagatggaa
      541 ttgaagtatc aacagaacct ttttcagcaa ggtattgact tgacacatat ccagtttgat
      601 tgccataact tacttttgtc catcctccac tttcagaaat acttccaacc tcagtaccat
      661 aacttaatgt agctatttta gaatgacttg tacctggtcc tgttctaacg ttcaatgact
      721 ttgctgttac aacctttgta ccctttacaa ggtcatttga actgttttca gcattttcat
      781 ttgtagagtc atttacacta gttcctaaat atttacttga aacataacct actctaccat
      841 tagaacttat ttttgaccat ccatttgact cagatatgta tccgacttca gtcccatatc
      901 ctagtgttga tattttagaa ctacttgtac ttggtcctgt tctaaaattt aatccttttg
      961 ctgttacaac ttttgtcgac ttaactgaag tatcactact ttcattgcta cttccaaggc
     1021 tatttattgc tacataattt ccatgcacat aacctgtgtt tccattatat ttaactttta
     1081 cccaagaacc ttcttttcct acgtactcaa ctttatcacc tttgtaaagt ttccccattg
     1141 attcatggtt tgtacctggt ccttttctaa aatttaccgc attccctgtt attgttctgc
     1201 tttctatact cacactctct acttcagact cattagcata tgctaaattc cccatagtag
     1261 gcattattat cgcagttgcc attatactgg ctgctattct cttttgatta aaattcataa
     1321 ctttccactc atctcctctt ttctactatc tttatttcac ttcaaaatat aaaagaaata
     1381 attgacacta ttaaaatatc aattatttct tttatattaa tattattaca aatttgtaac
     1441 tatttgtcta tagtaatatt tgcttaccat aaattaccat gtataaattt taatctttaa
     1501 tagcctgtaa tttagtaata tagccatctt ttaccttttt taaaaatggc tatatttttt
     1561 aacttttttg taacttttta aaatccagtt gagccaaacc caccttttcc tctttcggag
     1621 tcacttaatt cttttacttc ttctatgtta atatcataga taggttttac tatcatttga
     1681 gcaattttca tatgcttttc aaccttaaaa tcatttttac catgatttat taatataatt
     1741 ttaagctctc ctctgtatcc ttcgtcaata gttcctggtg tatttaatac agtaacagaa
     1801 tgctttaagg caagcccact tctaggtctt acctgcgctt ctgtcatagt aggaagctct
     1861 atacatatcc cagttttgat aagtttagtc tctccaggag gtattacaac ctcttctata
     1921 gaatacaaat ccataccagc atcacctttg tgagcaaaat taggtattat agcatcatca
     1981 tttaattttt ttacttttaa attgtacatc ttatatctcc tttcaacttt ctataaatat
     2041 tataacttaa atttcgacct cttgaagttt tttatttttt tgtggtaata taattattag
     2101 tgttttaaag gaggattttt tatgaaactt gtacttgctg agaaaccatc tgtggcaaaa
     2161 actatagcat catttttagg tgcaaagacc agacaagatg gttactttga aggaaatgat
     2221 tatataatta cttatgcagt tggacactta gtatcattat atgatatgaa ggattatgat
     2281 aaagataaat actctggctc ttggaaaatg aacaatttcc catttgttcc tgaggataag
     2341 tttaaattta agattgatag ttctaaaact aaacaattca acactgtaaa aaagcttttg
     2401 aatagaaaag atgtagaata tgtaataaat gccactgaca atgaccgaga aggagaactt
     2461 atagcatttt taatattttt actggcaaaa aataaaaaac cagtaaaaag aatcttggta
     2521 aatgaatgga caccagaaga tattacaaga ggtataaaaa acctaaaaga tgaagatgaa
     2581 atgagaaatc ttcaagctgc tggatatact aggcttatta ctgactggtt gattggaata
     2641 aatttcactt ctgttgctac attgaaatat ggaaatggga aactattaaa cataggtagg
     2701 gtaattcttc caacagttaa attagtctat gatagagata tggaaatact aaactttgtt
     2761 cctaaaacct attatgaaat agaagggcat tttaaagctg aagctggtga atataaaggt
     2821 aaatatgtta agggtaaaga aagtaaattt gatacacttg aagatgcaaa taaaattata
     2881 gcttcaatta catctgaaac tggtaaaata ctagataaaa aagttactat gtcaaaggaa
     2941 tatgcaccaa aactttttag tttgacatca cttcaaggat atataacttc taagtattcc
     3001 aattttacat ctgataaggt tttaaatgtc tgtcaatctc tctatgaggg taatggtaag
     3061 ggtggataca taacttaccc tagaactgat tccattttct tagaagaaag tttggcttca
     3121 aaagcttctc aaactttaga taaattaaag gttggtcttg aatatgaaaa taaaattaaa
     3181 ttttctaaaa ctaaaagagt ttttgattct tctaaagtag actcccatag tgctataatt
     3241 ccaacttata taattccaaa aagtttatct aaggatgaac aattagttta tgatgccata
     3301 aaagatagat ttgtagcaaa ctttatgcct cctgctgaat atgagaatac agaaattaag
     3361 actgaagtag ataattgtac tttcttaaca aaaggtaagg tgcttaaatc aaaaggatac
     3421 cttgaggtat ataataagga agaaaaaaac gatttacttc cacttgtaaa taaagatgat
     3481 gttgtagatg tgttagaaat aaaaccatta actaagcaaa ctactccacc taaaccatat
     3541 actgaggaca cacttttaaa ggctatgaaa aattgtggta aaaatgtgcc tgaagaagat
     3601 acaacagtgc tatctggata ttcgattgga acatcagcca cacgtgctga tgtgttaaag
     3661 aagataagtc aagtgggcta tgtaaagaaa aaaggtaaat cttattctat aacagacctt
     3721 gggaaaaatt tagttgaaat ttttcctgtt aaagacttat ttgatgtaga ttatactgga
     3781 aaacttgaaa aaagtttaag cgatattcaa aaaggaaagt atacaagaaa agaatatctt
     3841 actaatatca ttagttttat atatcaaaat gtcaatatta taaaacaaga tgcttcaaaa
     3901 aatataaaca cagaagcata tactttcgat tcaaaaacta aaaaatttac taaaacaaaa
     3961 gaaaaaaaac agaaaaaaga tgtaactaat actgaaaaag aagttgctat atcaaaggat
     4021 tctaataaca aaaaagaagt taaaaatggt gatgaaaatc aatctcttgg caaatgcccc
     4081 atttgtcaag gtgatgtact agaatttgac aaaggctttg cttgtaaaaa tcataaagaa
     4141 tgtaaatttg ttatttggaa aaatgataag tatttaagtc tttataaaaa gaaagttaac
     4201 aaaacaatgg tcaaaaatat tttaaaaaaa ggtgaaacta aagtaaaatc tttaactgct
     4261 aaaaacggta ataaatttga tgctacatta aaatatgata aaaatccaga tactggctat
     4321 ttcaattgga aaatagagtt tgacaactaa atattcataa gaaaagaaat agcagtagta
     4381 taataatcta tattatatta ctgctatttc ttttcttatg aagttttaac ttttttaata
     4441 gtgactttta caatcacact ctaacctaat ttctttacta tttctgataa ctttaatgta
     4501 tgttcatcta ataaagttag ttcctcttca gaaagattag ataatttttt tactagagat
     4561 tctttgagaa tagcttttac tgcatcaaat aatttaaatg ctttatctgt taattcaacc
     4621 ctaagaatcc ttctatcttt tgggtcagga aatttattga ctaaaccatg ttccactaat
     4681 ctgtcaataa tcggagtcat atttgatttt aaaattccta aattagaagc tatttgagaa
     4741 attgatgatg aatttgatgt cataagataa agaattacct tagcatgtga tggagccatt
     4801 ggacattctt caaaataagc tttcattata tcagagttat tttgaaactt ttttaacaaa
     4861 tcgctttctt taaatatatt attttcaagc acaaataaaa aatctaaaaa agagtccgct
     4921 attttaagta tattgttgtt atccatattt gtaacatccc ttcaatagat aatataataa
     4981 aacattgttg tttaatatag tataaattat aaactattaa taaatttaaa acaagaaaaa
     5041 gttattgact cataataatt ataaatttat aatcaaatta gagaattata aattgccaat
     5101 aaagggaagt tttttaatta gtctaaaact aaacttaaat tataagacac tttaaattct
     5161 acaacaagct agtgtgcaat atataatagg aggagatatg aaaagatatt taatagtttt
     5221 cttaatgtgt agttcactgt ttttagttgg atgtggaaaa acagaagaat ctgaacctga
     5281 gaaaccaata gcagtttctg ttcaaaaagc aataggtgga gaaattgaaa acacaaattc
     5341 tttctcagga actacaaagg ttaaagatga aacagctgtt actgcacaga ctgttggcac
     5401 agttcaagaa gtgtatgtaa aacttgggca aaatgtaaga aaaggagatg aattattgag
     5461 tataagcagt ccagagctag aaaatagtgt aaagcaaagt aaagcctcac tagatttagc
     5521 aaaagcaagt tattcaagtg ccactggtgg ttcattagag gcacaagtaa atcaggcaaa
     5581 aacagctctt gacaatgcaa agattcaata tgaggagtct caaagaaatt atgacaataa
     5641 taagattctt tatgaacagg aagtcattag tttagaccaa tttaaaaaaa tagaattttc
     5701 tttagagcaa acaaaacaac agttagattc tgctcaaaga gcatacgata cagcaacttc
     5761 aaaaagtata cctcaagcta aagcacttgc taaaaaacag cttgaccaag ctcaagtatc
     5821 atataattta gcaatgagta atttagacaa attaacatta acatctccag tagatggtac
     5881 aataacagct aaaaactttg attcaaagga aatgataaca caatcacaac cagcttttat
     5941 tatttctaat cctagtatac tagaagttga tttaaatgta gcagaatcag atataggtaa
     6001 atttaagaaa gatggaaatg tagatgttat aattgaagac caaaggattt taggaaaaat
     6061 agattatgta ccttcagtag ttgaccctca gacatcttta tatcctgtta aagtacttgt
     6121 aaataataca aacaacaaat ttaaggcagg tatgtctgct caagtaaact taagtgttga
     6181 aaaagaaaat ggtgctgtta cagtacctaa aaaagcaata tttgaagaaa atggtaaaaa
     6241 atatgtatac atagcaacaa aagacaatat agcaaagaaa cacttggttc aaactggaat
     6301 tgtaacagag gataaaatag aaattaaaag tggtgtaagt gataaagata cagtgattat
     6361 tggagggata agtcttattt ctgacggaac taagatattt cctgtagaaa aggagaagta
     6421 gactatgaat ttaacacaga cttccgttaa acgtcctctc acaatcataa tggtcttttt
     6481 agtattaata gtttttggtg gtattggata taaaaaaatg tcaataaatc taatgcctga
     6541 tatagaaata ccagttgtaa tggtcatgac tacttggaca ggtgctggtc ctcaagacgt
     6601 tgatgaacaa gttagtcaaa aagttgatga aagtttatct gccgtttcaa atgtaaaatc
     6661 tactatatca agttcacaag aaagtgtttc tatggtagtt gctcagtttg aatttggaac
     6721 taatttggat gaaataatga atgatgttag gtctaaagtt gatgcattac agaccagcct
     6781 cccagatgat gcagctaaac caacagtttt aaagctggat atgaatgcac aggccatagg
     6841 tcaacttgtc atatctggag gaaatgaaaa tagttcacaa gccttaagaa aatacgctga
     6901 agatgtaatt cagcctaaaa tagaatccat agatggtgtt acttcagcag accttaaagg
     6961 tggaaaaaaa gcacaggtta atgtaatagc tgacccagct gttctttcaa attatggggt
     7021 tagtttatcc actataaaag gtgtcttatc ctctagtaat aaaacattcc cttatggttc
     7081 aattactcaa ggtgaggata aaatagtttt aagagcgatt gataaattag aatccctaga
     7141 tgatataaaa cagattcaaa ttcctgtaaa aggaggaaat acagttagat tagataatct
     7201 ttgtagtgta gattatggat atgcagacaa agatagtatt tatagataca atggaaaaga
     7261 cagtttggta atagatattt ctaaacaaca agatgccaac actgtaaaag ttatgcagag
     7321 tgcatacaaa tacgtagatg aattgaataa ggaaaatcct caatttaaaa ttaaaattgc
     7381 taatgataca agttcataca taagtgaatc aataaacagt gtaatgagca acttgcttat
     7441 aagtgctgtt atcgcattta ttgtaatatt tgctttccta aaaagtgtaa gagcttcact
     7501 agttgttgca gttgcaatac caatttctat aataggtgct atagcaattc tctactttac
     7561 tggtgaaagt ttaaatctta ttactgcaag ttcattggta atttcagttg gtatggttgt
     7621 tgataatgct acagttgtaa ttgaaaatat atttaaatat aggaaaagtg gcagattgag
     7681 tcttgatgat tgtgctattg agggaacaag aactgtaaca aatgcaatac ttgcatcaac
     7741 attgaccaca atagcaatat tcttacctat catgtttaca gaaggtatag ctaaaataac
     7801 ttttggggca ttaggtaaaa cactaatagc ttcactagca ttctccttta taggtgcaat
     7861 tacactcgtt cctagtgtat ttgcaaaatt aagcagagga aaaaatagtc aaaagatgca
     7921 agaaaaagat agtcctatat ttgataaggt aagtgaagca tataaaaaat tattaagtgt
     7981 atgtttgaga catcaacgct tagttgtaat atcaagttta cttatttttg tagcttcctt
     8041 atttggaatg ggatttatag gtatggactt tatgcctgca gcagacaagg gtgaattatc
     8101 tatttctata gaacttccaa aaggtcttag cctagaatcc aatgattact atgtatctat
     8161 gactgagaaa aaagtctcag atattccaga aattaaaact ttaataacaa ctttgacatc
     8221 agattcaaat aatagtaaag caagtatagc aattgaatta gaatctcaaa aaaatagaaa
     8281 aagaactact gatgaaatag aaaaagagat aattgataga gtggctactg taccagattg
     8341 taaaataaat gtaagtcaaa acagtagtgt tatgggtgga gctggaggag cagacttcac
     8401 attagaaatg aaaggtcctg atttagatgt attaaaaata ctgggaaaag aagctgaaaa
     8461 agaatttagc tctataaaag gatttagaaa tgttgaaact tctcttacag atacaacaca
     8521 agaagctcaa tttactatag ataaacataa ggctcaagaa tatggtgtaa ataccgctga
     8581 aattgcaggc atgttacgta cagcaataaa tggtgactcc gtaaccactg ctactattga
     8641 tgattacaaa gtggatgtaa acctaaaatt taaagcagat actattgata gcttagaaga
     8701 tataaagcaa ctaaaagtaa actctgcaac tggaaaagaa gttcctcttg gtgctttttc
     8761 agatataaaa atggcagatg gtctacaatc tatatctagg actgatggag atttttctgt
     8821 aaatataact gctacacttg acaatttaga tgctggtact gctacaaaac tagcactaga
     8881 aaaaacgaat aaaatggtaa ttcctaaaga ttactctata ggtgttggtg gtgaaacaga
     8941 aatgatgaat gaatctatgg caagtcttgg attttcaatg gtcatagcta tagcattagt
     9001 ttatatggta atggtagctc agtttgaatc atttagtaaa ccatttataa tcatgttctg
     9061 tgttccattt gcattcgttg gagttgtgct ttcgcttcta gttagtggtc aaagtttaag
     9121 tactgtcggt atgctaggta taatcttact tatcggtatt gttgttaata atggtatagt
     9181 tcttattgac tacatagagc aacttagaaa aacaaatcgt aacaatgatt taattggttt
     9241 ggtttcaatt ggttgtgcag caagattaag accagtctta atgactacag caacaacaat
     9301 tttaggtatg ttgccaacag cactatctct tggtgaaggt ggagaaacta tgcaaccact
     9361 agccatagtt ataatgggtg gtctaactgt atctacactt ataactttgg tgcttatacc
     9421 tactatatac ttaatatttg ataaatggga aaataagttt tcagacaaaa tgcctaaaat
     9481 atttggtaag ataacagata aaataggaag tataaaacgt aaaataataa agaaaccaaa
     9541 attgaaagct aaagtttaaa tagaatggag ggtgattgta ttgaataaaa aaatgagcaa
     9601 aatagttgca attggctgtg gtgttggtat aataactgcc aatttaatcc cagtttacgc
     9661 agataataat acttcttcta taaacaaagt tgataattct attttaagtg actcaaataa
     9721 aagaacatct gaaaaggaaa ttttgactgc tagagaagct gttagtgctg cacttaaaaa
     9781 tagtgaaaaa ttaaaaatga aatcagaaga aataaaaatg ttaaaagaaa agttagaagt
     9841 acaagatgag tttgatagtt ttactggaag tgacaactcg tttccatacg accaaattgg
     9901 acttcttaaa aatcaaagtg aacaggctaa aggctttatg gaggaccaaa tagcaaatga
     9961 tattactaat aaatttaacg atttagtttc aagagaaaat gagctagaca agataaaaaa
    10021 caatcttgaa ataaaaacta aagaaattaa agatatgaaa ttaaaaaaag atttagggtt
    10081 agtaacatct ttagaaactg aatcagctga acttgaactt caaacactac aaaatactca
    10141 aaaagctaaa cttcaagaac taaaaaacaa tcaagactac tttaagttgt tgactaatat
    10201 agatttaaat aattatcaat tggataaaga atatagattt gaatctttta gagtaggtgg
    10261 ctcagttgat tcatatatgg aaggtaaggt taatgaatat ttaaaatacg accaattgat
    10321 tttagaacgt acagaagaaa gctttaatga taaagatgag aacaaagcag atttaccaga
    10381 tagacctaat cttacaagac cagttgctcc tacaaaacca gagcaaggta acctaactga
    10441 tgatgaatat aaggttctta cggataagta tgaaaaagac tacaagagat atgaaaaaga
    10501 agttgaagca tacaatcttg aaagacagac ttatgctgct ggccttacta cttatgcaaa
    10561 ttatcttcaa caaaaattta ataccgaaaa tggtctagta acattagaag acagtaaaaa
    10621 agctcttaaa aaagggttaa ttgatagcta tgctcaatta cttgctttag aagatacaat
    10681 tcagattact aaaaaacaac ttgatttatc agaaaaacaa ttaaaaaata ctaaattaag
    10741 atatgattta ggattaatta ctctaactga ttataaaaaa caagtggtaa gtaatgaaga
    10801 tgctaaaaat agctatgaca ctcttattgt gaattataac tcactaaaaa atggtataga
    10861 aaaaccttgg atacttaata ctggaaaata attctggtaa atagaaagat tactttaaca
    10921 tacgtttgat taaaaaatag ttatgcacac tcgtggcttt agtcatggaa gattcagaag
    10981 gcaaataata gaaatagatt agtaaaaata tatttgctta taaaactgta taattttata
    11041 gaggctatct caaaatagag ataagcctct tttttattgt ttaaattata aaaatatatt
    11101 taattccata caaaaagagt gccttatgaa ctaaaaagtt cattttgaga caccctcaaa
    11161 agcttaactc taaatttaat tattttttat caaatgtctc atctatttta catctcacca
    11221 tgttaacaaa ttcagaaata ttatatcctc taagtttgca tccacattta ggacaataat
    11281 ccaatttcct agataccaaa gccctacaac taggttctgg acatcttatt tttagactct
    11341 catctgctac tttaaatcca catcgtgggc atatactacc tggacgtgat gatacttcct
    11401 ttccacattt aggacacttt gtcaacttta tcccctccag taaactcaat ttaattgata
    11461 gttgaaattt ctctctacaa taatatatgc aatataatta aatacgtttc acttacaact
    11521 atataagtta aatttttata ataaaaatcc cctatattca atttacaaat acttaatttg
    11581 atacattgaa caatagggga ttttattttt atttagttac atattttgca gtctattatt
    11641 atctaggatt ttttatagat gcttgagctg ctgcaagtct agcaattggc actctaaatg
    11701 gtgaacaaga tacatagtta agtcctacac tataacagaa ctctactgaa gatggttctc
    11761 ctccatgctc tccacatatt cctagtttta attctggttt aacttctcta cctaatttag
    11821 ctcccatctt aactaactta ccaacaccat tttggtctag tacttggaat gggtcttttt
    11881 ctaatatttc ttcatctaca tattgaccta agaatttacc agcatcatct cttgaatatc
    11941 caaatgccat ttgagttaag tcattagtac caaaactgaa gaagtctgct tcttgtgcta
    12001 tttcatcagc agttaaacaa gctctaggta tttctatcat agtacctaca gtataaggaa
    12061 cttctatacc ttcttctttt attatagcgt caacagtttc tactatcatt tttcttatta
    12121 tttttaactc atttacttct ccaactaatg gaaccattat ctctggagaa actttaacac
    12181 ctgctttgat tgcttctata gcaccttgta ttatagcttt agattgcatt acacatattt
    12241 caggataagt tattgcaagt ctacaacctc tgtgtccaag cattgggtta aactcatcta
    12301 aatcaactat tctcttctta atatcactta cttttattcc catagatttt gaaagttctt
    12361 ctatagtctc atcatcatga ggcaaaaatt catgtagtgg tgggtctagt aatcttatat
    12421 taactggttt tccatccata actttaaata actctacaaa atcttctctt tgcattggta
    12481 atattttttc aagagctttt tctctttgtt ctactgtatt agataatatc atttctctaa
    12541 ctgctggcaa tctagcttca tcaaagaaca tatgctcagt tctacataga cctatacctt
    12601 ctgcaccaaa ctctatagct gcacgagcat ctctaggatt atctgcatta gttctaacca
    12661 tcatacattt gtgtttgtct acccagttca ttaatttttc aaaatttcca gttaaagata
    12721 cttctgtttt cttaacatct cctaggtata catttcctgt agaaccatct atagaaatgt
    12781 attctccttc ttttataact acatcatcaa gtgctcttat ttctttatta aactcatcaa
    12841 cttttatttc tccacatcca gcaacacaac atttacccat acctctagca acaactgctg
    12901 catgtgatgt cattccacct ctagctgtaa ggattccttc tgctttaacc attccttcta
    12961 tatcttctgg agatgtctct agtctaacta aaactacttt ttctcctttt tcatttgctt
    13021 ttactacatc atcagcattg aaataaactt taccacttgc tgcacctggt gatgctggta
    13081 aaccttttgc tataacctta gcttctttta atgccttatc ttcaaatttt ggatgtaata
    13141 attggtctaa ttgattaggc tcaattctca tgatagcttc tttttcatca attattccag
    13201 cttcaactaa atcaaccgct acatttattg ctgctgctgc tgttctctta ccatttctag
    13261 tttgtagtat atataatctt tcattttcta tagtaaactc tatatcttgc atatctttat
    13321 aatgaccttc aagtatatga gtaattttta caaattcatc gaatacagct ggcattacat
    13381 ctgcaagagt tgatatattt tgaggagttc ttatacctgc aacaacgtct tcaccttgtg
    13441 cattcattaa aaattcacca aataatttat tttctcctgt agctggattt ctagtaaatg
    13501 caacacctgt accactagtt tctcccatat taccaaatac cattgattga atatttactg
    13561 ctgttcctaa gttatgagct atatcattca atttacggta tacgattgca cgaggattat
    13621 tccatgatct aaatacagcc tctattgcaa gcattaattg ctcttttggg tcttgtggga
    13681 aatcattttt tatttctttt ttataaattg ctttaaattc ttttactatt tcttttaaat
    13741 catcagttgt aagttctgta tcaactgtgt atccctttgc ttcttttact ctgtctaata
    13801 cattttcaaa tttatatttt ggaacttcca tagcaacatc agaaaacatt tgtatgaatc
    13861 ttctgtaact atcatatgca aatctttcat tttgtgtagc ctctgctaag ccaacaacac
    13921 tattgtcatt aagacctagg ttaagaattg tatccatcat tcctggcata gagaatactg
    13981 caccagaacg aactgatact aataatggat tcttattgca tcctaatgtt ttatttaagt
    14041 ctttttctaa agtagctaaa tgctcttcta tttcttttat tatctctgct cttatacttt
    14101 cattgttaac ataataatca ttacatgctt ctgttgttat agtgaatcca ggagggacag
    14161 gtaagcctat cttagtcatt tctgctaaat tggcaccttt acctcctagt aaagatttca
    14221 tgtctttgct tccttcacca aaactataaa catacttagt ttccattgtt aaatccccca
    14281 ttaatctttt tattttaatt tatatcattt ttattaatag acattattaa atttctattt
    14341 ctttgtatat ctttagacca ttttctttca ttatgtctaa aattatacct gctgtttctt
    14401 ctattgcctt atttgaaacg tttattactg ggcatccaat tcttttcatt atctcttctg
    14461 aataatctaa ctcctgaagt attctttcta aattagcata gtttgcttta ctggacaatc
    14521 ctaaagcttt taatctttgg gttcttatct cattcagctt ttcaggtgaa ttagtaagac
    14581 ctattatctt tttagtatct atctcaaaca cttctttagg aattggtatt tctggaacta
    14641 atggaacatt agctactttt atatttttat tagctaaata catactcaaa ggagttttag
    14701 atgttcttga tattcccact aaaattatgt ctgcttgaag aacacctcta gggtcttttc
    14761 catcatcata tttcactgca aattctatag cttcaactct cttaaagtaa gattcatcta
    14821 attttctaat tataccagct tctcttttag gttttcttcc tgttctcttg cttatttctc
    14881 ttagtatatc tgtcattaaa tctatacaac taagaccttc tctttcgcaa tatctttcaa
    14941 caatactgca taattcttca tcaactaatg tatatacaat taaagcgttt tcagcttttg
    15001 cattctccaa agtttcaagt agtactcctt tattaatcat gtatggaaat ctttttattt
    15061 cataagtttc attcacataa aactgagaca tacatgcctt tgcaacttgt tgtgcagtct
    15121 cccctactga atctgatact gcatatataa ttaggttttt caccagcata cctccttaat
    15181 tgtcaactat ttctaagaat agcttagtta tgttggtttt tgatattctc ccaacaactc
    15241 tcatatgatt tttgtcttct cccttatatt caacaatcgg aatcgaatct acttcatgtt
    15301 ctattatttt tcttgaagct aataaaacac ttgctccttt agttaaagtg actacatttg
    15361 gagttcttgt cattatcata cctattggca ttttatttat atcagaacct cctatagttg
    15421 cttttagcaa gtcttttctg gaaacaactc cacataactc ttcattctca tctataataa
    15481 ctatactccc tacatcagat aaaaacatag tgactattac atcatatata ctttcatcct
    15541 tcttagctag tacaggcatg ctcattatat cctctactgt tttttctttt acacttttac
    15601 caattaaatt tatttcacta actcctgaat aaaaatatcc aacttttggt cttgcgtcta
    15661 atattcctgt cattgttaat atagctaaat cagatctaag tgtagcacga gtcacattca
    15721 agctggaggc aatactttca ctcgttattg gttcattttc cttaactata tctataattt
    15781 ttagttgtct ttcattaagc tgaataataa tcaccttctt tcattgtgct atacttttta
    15841 tcttttcgca tcttatatag tatattatat aactatatat accattctgt aaacagattt
    15901 tttattgaat acgatatatt ttttactaag ttctctcgct taaagatatt tattatatat
    15961 taatggggga tatttcttta attaatagaa ctatattagt attacagtta atattataat
    16021 acataattgg tcattttaat tcattttata ttaaaatttt taataatatt atttcaatgt
    16081 gaatataaaa ttgcagaact aattcaaaat aatttttacg actacaaata acctataata
    16141 tacttttaaa gaaagtatcc taacaagaat atataaaaat ttaaaagggt tgatttaaaa
    16201 ataaccatca acccttttta ctaatatcta tttatattac catcaaatct tacccaaata
    16261 ttttttcttg caattgtctt aaatgatata aagtagtatc tttttctatc tctaccatat
    16321 cgtaagttat aacttcacct tttttaatat cttttacaac tttagtcttt ttacttatca
    16381 aaccaatagg tacagcattc atagcctttg ctacatcgta tttttctata gtaccatagc
    16441 atgtatatgc tccatagcca tccataaact cacctttttt caaatctttc ttagctatag
    16501 tcataacttc tgctactagt ccagctttag gtactattgt agccttatgg tctaaaactg
    16561 ccatagctgc tgataaagga gtctctaaac tacataaatg atatggtcta tataatatgt
    16621 aattaggtcc atcacccata cttaaatatt ttagttcatc attaactgct tttaatttat
    16681 gggcaactac tacgaaaact ccaggtgcta taccatttac aaaatcaact acaccataat
    16741 tatctaatac tccaccttcg ctttttaatg catatttctt aggtacttca ttaactgtag
    16801 cttcaatacc atgaccacct cttacatcag gcacaaatcc agttgcatta cacattaaag
    16861 ccatttctac cattgtttta gttccttctt taaaagaagc tatcatatga ggtgaagctc
    16921 cttttctttc tgcttcttct ctaactgtat caggattaca atctaaatct aatttattat
    16981 ttttaccttt acctatcact ctaacttcaa accccattgc atctgcaaaa tcaaataatt
    17041 ccattactgc acctggctca tctcctgcag aacctgtaaa tattactcca gcatcatctg
    17101 ctaatttttt aagtattggt ccaacaacac aatcagtttc agcatttaac ataactatat
    17161 gttttttatt taaaatagag tttaatgcta tctctgcacc aattgcaata cccccagttg
    17221 catctataac tacatctatt gacttagttt tacaagccac aagaaagtca ttacatgtca
    17281 atacttttcc ttcttgtaat tttatttctg catccttttc atttgttaca ttatctataa
    17341 tttcttcatc tattcctgca tcagtaaaag ctttatgagc caactccaaa tctatatcta
    17401 caacaataga agcttcaata cctttcatat ttgccatttg gcttaccatt ccatttccca
    17461 tatgcccagc tcctataaga gctactttta tttttttacc ttcctcttcc aattttgcaa
    17521 gttttctgtt taaatctaac ataccaattc ctcctgttat aataatttta ttttcaaatt
    17581 aagaaatagt tattaaatct ccaatagtta tatctggatt tcctatttcc acatgtattt
    17641 ctcctggtaa atttacttca cattttccat caaatttgat tgtacaatgc ccaatttctc
    17701 taagagtctt ctgagcaata tcaccaactg aaactataca ataatctcta ttccctatag
    17761 taagtgtatc tcctatttca acatcacttt ttaatgttgc tattgaatga attacagata
    17821 tatcctttaa gtcgtcatca ttaatggttt catcatatat aataagacaa ttgctttcat
    17881 ccattaactc tttaactaaa ctgcctatcc cacttatctt aacttcatat ttcatgacat
    17941 tcctcctgat aatttatatt tatattgagt taattaaaag aaacatttat tttttctttt
    18001 ataaatttta tagcttgtac aatactctct tcatctttaa atttttgctc tgcactatat
    18061 atatctaatc cttctatttc ttcaatctct ttaaatttag ccattactgt acgccctttt
    18121 aaaatttctc caaactttat aaacccatct gaatctgaag atataacggc tatacttcct
    18181 ttagaaaaat agcttttctt tttgcctgta gacactatat cacccttttt tttagctcta
    18241 tttaaagttt taaaatacaa tttattctgc ttcattataa atatagtatt taaaatataa
    18301 gcaacaaata aaattactaa taatttcata tttatacacc ttccaaaaat cacattattt
    18361 ttaaatctgt ataacaacta taaatgctgt acaatagtta tataaggttt ttaagtaaca
    18421 cctttttaaa ttctaaaaaa gttctacatt tacttatctt attcgttaat tttacatctt
    18481 ggcctatctt taaaacttct tcataaattt ttactaataa gtctgagtct atcttattct
    18541 cacatggaaa cattgtcata agaattattt ttatacttct atttgcatat tctattggtt
    18601 cttctaaaat tccaactgcc attaaaaact tatctgattt ttcatttata gaatgaggaa
    18661 ataataaacc tttatcaaat actgtgggag atttttcttc tctattgact atattttttc
    18721 taaacttctc atcaatacat cccaaatcca taagatggtc catcattttt tctaatgagg
    18781 caagtatagt cttttcattt aatatcataa atttatcttc atctaacaaa ttatttatta
    18841 gtaaatttgt agaattagta gtgtcaatat tcccttctct taggcacaat actgttttta
    18901 attgttctct tagtttgttt tcatcaaata ttgtatttat ttttaatact attgtattta
    18961 tatttgatgt gtctaaatca atagttgtaa aaactatatc gtattcatct aagttaatat
    19021 ttctcaaatt aaaacttgaa agagtatcaa ttttaggatt atttcctatc agtttttcta
    19081 ctcttatttt caatagtttt gctgttccta gacctgtact acatataatt gctatttttt
    19141 ttattgaata gaatctactg ctatttcttt ctaaatatcc actgaaatgg attgctatat
    19201 atccaatctc atcttctgaa acttctaagt tatacttttt ctctattact tttcctgcta
    19261 tttgtgctaa tttaaatgga agtatataat tttgcttaat ctcttctaac aaaacatttt
    19321 ttaactttat attaaataat agcctgttta aagtaaaact aagatgatat cctagaccta
    19381 ctcttaattc atcctcattt ataaaaatac ccatatcgac atatatttga ttaaatatat
    19441 tttccatcaa ctcatcaatg tttttactaa ttctactact atttaaagca cattctgatg
    19501 ctggtgcatt tccactaact aacggtatag ttaaataaat aatttcttca tcatttaaag
    19561 tacattcaaa cattcctgat attatatgtt ttatttccct agcaataaag tattcatcat
    19621 atgatttaag taaatcaaac tttacatcat aatcttttac tttcttttct tcttttactc
    19681 tatagactaa aactactatg tagttaataa cttctcttaa catttcatct gtaacataaa
    19741 aattattttt tttaaataaa gtcaatagtt tttcttctaa atttatgatt tcttcttttt
    19801 tgattccttt aaaatacttt gaattactga aatctttcct tgagttttta tacaactgat
    19861 ttaatataaa cagtctaata tcaagttcat ttccatttaa tttcatacct gtattctgtt
    19921 ttttaatcaa gtttaaatta tatgaagcca aaactttttc tacatactgg aaatcattta
    19981 ctaaagtagt tcttcctaca cacatctcat cagctaaact atcaagtgta ataaatccat
    20041 ctagttctat caagtaattt agtataaact ctactctatc ttcttttgaa tttaatgaaa
    20101 atacattttt tctattcata tcaataatct tattgagtat ctgctcatct tttatttcta
    20161 gtttatagcc ttgacccttt atatatttga ttactgctat atcattacct aaatctttat
    20221 tcaattgttt tatatacgtc cttacacttc tagttgtgac attcaattca tttgctattg
    20281 agttaatact cacaaactct tttttactac acataatcaa tatcttaaat atcttgcggt
    20341 caatagaagg aattttctca gttacactca ttttgtatct cctccttgat ttcattctag
    20401 tacaaatttg aaaccaaatt aatacataaa atttcacttt aataaaggaa aatttagtat
    20461 taatctaact cgataattac agctaattaa tagtataaaa gctagtcttt cattaacaaa
    20521 aaatcttgac tagcttaaat ttatatttac aattttatta attaattcca agccttatat
    20581 tgacattaaa tattatctca atgcaaatac tgcaactcca tatgcaataa taacagctat
    20641 tggaccagtt attaaacgag agtaaaataa agctggaaca ccatactcta cagtttctgg
    20701 ttctgcttct cccaaactta atcctactgg tacaaaatca catccagctt gcccatttat
    20761 tgcaaataaa gctggaagtg ctaaatatgc tggtattgca ccaagaccaa tttgtgtacc
    20821 tacaagagtc cctactactt gagctataac tgcaccaggt cctagtattg gtgataagaa
    20881 tggaagtgtg caaattactg atataatcaa taatccacca atattacctg caagtggaga
    20941 tataactctt gcaatccagt ctcccagtcc agatgctaaa ataattccca taagcatact
    21001 tacaaatgcc ataaatggta ttacgttatt cattaccatt tggatagtat ctcgacctgc
    21061 atcataaaat tttgatacta cttgccctgc cccttgacca atagaaagta ttatgttctt
    21121 tttagcatat tcaccttgtg cttttgactt aacctcatca taattatcag gctttctaat
    21181 agaactctta ttttcgcttt tattttcttg agatttttgt ggcatatctt ccccatctac
    21241 aacacttata cagttaggat taacatctga tacataatat tcttctgtta taaattttgc
    21301 taaaggacct gtttttccaa ctggatttac atttattgta ggtatttttt tctttggata
    21361 aactccacat ctagcagttc caccacaatc aataataact actgctactt cttcatcaga
    21421 aactccagtt ttaaatccat ctacaatttc acaacccagt agttctttta tttttaatgt
    21481 tacttcatgg ataccgccag cagtcattga tagtatctta tttctattcc cttctttttt
    21541 tatatacaaa ggacctcccc agcctgaagt tcccttttct atttttaata ttttattctc
    21601 ctccatttta tctacctcct aagccttatt tgttgctcta ttttttcttg ttagaaaagc
    21661 atacattttt tctgttacta tacctcttat aaaaattaca attagaccaa ctataaaata
    21721 ccacaatgcc aatgtagtag tttctttacc taaagtagtc aaacctgcag atattcccaa
    21781 ccatacaaaa agttctcctg catttgcatg tggaaaaaga cctgtaattg gatgtacaaa
    21841 tgaaactgct gcatcataaa atcctgcttt gtgctcttct tttaaaaatc taccaaatgt
    21901 atagcacata ggatttccca agaaaaatac tgatactaat ggaagtagaa tatatcttgt
    21961 aaaagagttc tttcctagct tagaagccca attattaact ctttcctcac caattatctt
    22021 aatcaaagag ttaatagcta ccattaatac aattagcgtt ggaagagtac ctgaaacaag
    22081 acctataaat tgttctcccc ctttctgaaa caaaccgata aaccactctg cacctttact
    22141 tagacctgta ataacgtttt ccataaaatt ataacctccc tataatatct ttaaattttt
    22201 aattttactg cttaccataa attttacaaa ttacatcttt tttctgtact atatgctaat
    22261 attgtaaatg tttttttatt aatatcattt taatataata tttttgataa ataaatacat
    22321 cttttttcaa ttttataaag gaaaaaattg tactaattag aattttcaga aatatacaat
    22381 tcttatttcg actatattct aaattcttct tagaaattta agaacttatt tttatttctt
    22441 ttattattaa aattatctaa atcttataaa aataaaaaat agatgctctt ttacgaacat
    22501 ctatttctta atcaaattat cttttagttt tcttatagat tattttatag gtatataaat
    22561 atcaatttgt gagttcacat tactaggacc taaaaatcgt tcatcatata cttcaaaatc
    22621 atctcttata tcaagttctt cttttgaact taaaaaccaa gtaccccata tatattcata
    22681 agttttgtct aaattatcta agctaccagt atgagtaaat atagcatact ttccttcctt
    22741 aatagttttt gaaacaaatg aatttggaat cacatcataa ctattaactt caagtcctat
    22801 tatctcatta aactccatac tttcactaac taggtgtatt tcagagattg cttcacagat
    22861 tccaaaaact ctccttgatg gcaaagtatt tgggacaata tgatgtactt ttctgaattt
    22921 ctcccacaag tcaggtaatg aattattttc taaaattact ttatccttta tacctattac
    22981 ctttattttt tctatttctt ttataactgg tttaatcgtt atatttccaa caagatgtct
    23041 cataaaatct aactctaatt ttttcttttt accaacaaat acatcaattc tattttttct
    23101 atattctata gggctaacct tgtatataga tttaaatgct ctgctaaatg cttctgaaga
    23161 ttcaaatcca ctaccaatag ctatatctat cactttttta tcactatata aaagttcttt
    23221 tgtactactt actaatcgtc ttttttttat ataacttcct acactttcac caaacataga
    23281 cttaaataag cgtgttaaat gataataaga atatccagtt tcttttgcca catcatttac
    23341 agttatattt tcatgtaaat tattctcaat atacattaca gctttttcaa aatactttaa
    23401 gtaatccaat atggcacctc tcttctactt aaactcttta aatatgtaaa atagcactat
    23461 tttttactat actaaaatat tataactaat tcaatacgat aaataaaaac ttttagttga
    23521 tttatatgtc ctaattattt agaataatta aatacatttt ttattcaatg aaatcaaaaa
    23581 agtcagatgg tgctttttca atatttatgt ttatcctctg tgttatagat ttaatgtcat
    23641 tttttaaata gtagctctcc catttattct ctagtccacc ccataaaata ttaaactttc
    23701 ctatatttaa atccataact atacttttta aagttccaaa aaaatcatta tagtaattac
    23761 aagataagcc atttggatat tttgaagaca ataaattcat taactctttc tctccaattt
    23821 ttttagactt atttatatat tctttaatta atttatatct atgaatagaa tttttcattg
    23881 attgtggatc taatttatga agtttatcaa tatgtgtatg attagtagag tgtaaaaaat
    23941 attctctttt actttctaaa ctgttgatta tatttacttc ttttttccca tctaaagtct
    24001 ccacaagtgc aatgtttcca gacttatctg caagcaataa attaatattg tatgcaattg
    24061 gcatatcttt taaatattct aatgcttcat ctacatcttt gcaattttct aacaaatatc
    24121 taataacagc ccaaaactgt aaacctacaa ttgctggttt tcttaaacca tctgaattgc
    24181 ctacaggaat accacatgat gactgactta cacctaagcc acattcattc ataccttcac
    24241 ctcttccaaa ttgcataatg gtagtaccta tatgtgcata ttttccattt accttagttt
    24301 tacataaaac aaaatcctcc atattgtgtg agaaatcgaa attacgtgca aatagtacat
    24361 gcccattttc agttaattct ggtgctaatg caacttgact acaacctggt ttaagataag
    24421 tcatagtata atataaaatt tgattacaat tcacttgaat tgcatcagca aaaccttgca
    24481 attcttcatt aagacctgga caatatttat caaacaactc tatcatctct ttttcttctt
    24541 ttttgcttac cagattagat ttattaatct gaccttctat tatctctggc atattagcaa
    24601 ccaattctcc tagtctgtat cctatctcat aatttgtacc actcaattca atatttctta
    24661 cttctaaagt ttccatatgt acccctccta tatatcttat aatcgatttt atcattcgaa
    24721 ttgtaatcat tcatgatatt ttgtgctaca agttaaaaaa ggtcatataa aaacagataa
    24781 gcctcttttt catgtttaaa ataataaaaa tatatttaat ttcatacaaa aaagagtgtc
    24841 tcataaacta aaaagttcat tttgagacac tcttcttatt ttaaagagta taattaaaaa
    24901 tagtctaagt tctactcttc cttcattttt ttcaataatt ctggattttc aaataaatta
    24961 aatcctgtta aagctaatat ttttatacca tcaattactc tatcttttgc atatgaattt
    25021 atagaagcct ccaaaaattc ttttgtatgt agttcttctc cattttcaga aaacttcatc
    25081 aaaggatgta tacatggcat tatttgactt aaatttccca tatctgttga acctaacatt
    25141 acttgttcat cttcatatat tccaaattcc tccataatct ttgtaaatat gtctaccaaa
    25201 actttatttt catttaatcc ttggcaagtt ggttcaaagt gataaaattc aagttcacat
    25261 ccagtggcta ttgcagcacc tctagcacaa tttttcactt tttctactac ttcatcaaag
    25321 taattttgtt cttttgccct tatctctaat cttacttttc ccatatcagg tattacattt
    25381 gcagcagttc ctgcttctaa tataatacca tgtattctcg ttccatctac taattgttgt
    25441 cttagtgcat ttatattatt atatagtagt actactgcat ctaaagcatt tattccgtta
    25501 tatggcttag ctcctgcatg agatgctttt ccagtaaata tgaaatctag acctcctatt
    25561 gctataattt caggtgttac acaagttttt gaatttggat gtatcatcat tgctgcatca
    25621 tagccatcaa atacaccatg ttctatcaag taaggctttc catctccagt ttcttcagca
    25681 ggtgttccaa ttatacttac ttctcccttg taagtatcca gtatacttga aagagctatt
    25741 ccagctccaa ctcccataga tgcaattaaa tgatgtccac atgcatgtcc attgcctgga
    25801 agagcatcat attctgctat aaatgctatt ttaggaccat ctccattttt cttggttgct
    25861 ttaaaagctg tagccatacc tgccaagttt tcctcaacat caaaaccctc ttctcttaga
    25921 aattctgata tttttttagc agatttatat tcttgcaaag caatttctgg ttcatcatat
    25981 aaagattgac atagccctag aattttttct ttctttgaat cagccacttg tattattctt
    26041 tctttcatac caatcttacc tcccactaaa tttatttagt aatttttata ttttattata
    26101 actttaattt aactcatgct tatcctcttt taagtatcta ttttcccaaa actcagcatt
    26161 tcttatatct aactctatag ggttaaaagt tctatcactc ctttttattc ccatcttctt
    26221 ctgtcttata taatcataat atgcctttat agctggtttt tttagtgtaa agatggcaat
    26281 taaatttata tatgttaata cacctataca tatatcacct aatgcccagc ttgtaagtgg
    26341 ttctataaaa caacacattg ctgcacatgc tataagcata aatctacaga cattaattat
    26401 gtacttttca tgtttttctg ctttaattct agttactaag taagatacat tagtctccat
    26461 catatatgag aaggctaata aagttgtaaa tgtaaataat aataaaacta ttgctataaa
    26521 aatatcacct aattgtggat gtaatgtatt tattgcactc tgtacatatt gtggtcccgg
    26581 ttctacacct ggtagtgctg tgcaaacacc tgtaacatta tacattcctg ttattacaat
    26641 cataatacct gtagccatac atattaataa tgtgtctaca taaacagaaa atgcttgaac
    26701 taatccttgt ttggctggat gacttacttc tgctgctgcc gcaccataag tcccagaacc
    26761 ttctcctgct tcatttgagt atatacctct ttttactccc caagatattg ctgaacctag
    26821 cattcctcca aaaactgaac caaatccaaa tgcagattta aacattgtta caatagcctc
    26881 tggaactaaa ctaatatttg ttataattat tactaatgtc ataataaggt atgctccacc
    26941 cattataggt actacttttt cagcaaataa accaatcctt ttaattcctc caaaaattat
    27001 tatcgctaat gcaatagaag atgctactgc tattgtcatt tttgaaaatc caaatgcttg
    27061 attcattgct agatataaag tgtttgattg tgtaccaggc ataaaaaatg tataacttat
    27121 tattgcaact attgaaaata aaactgaaca ctttttccac ccaagacctt tttcaaaata
    27181 atatggaggt cctcctctat actgcccatc atgctcatct ttatatattt gagctaaagt
    27241 agattctaca aatgcagttg ctgaacctaa tgtagccatt atacacatcc atactaatgc
    27301 tcctggacct cccattgcta ttgctacagc tacaccagct atatttccag tccctattct
    27361 tccagccata gatgtagcaa aaccttgaaa tgatgatata ccaacatgag aactatctcc
    27421 ctcaagcaag agagtaaaca tttcttttac atctcttatt tgaaaaaatt ttaatttcaa
    27481 tgaaaaatat aatcctatac acaaacacat tgcaactaat acgggtgacc aaacaattcc
    27541 attaatggtg ttaactaaat cggtcactta actcaccacc attcatttta tatttataga
    27601 caataattta aacagctata tttcaatatt ttatataatc tttatattaa tatatctaaa
    27661 aaatctacct tctatttatt tatattatct ttaatctaca atctacaaat atttatttct
    27721 aaaatcaaga gtattaatca tatctaaaca taaatttata aaatttttaa cgacgtgtgt
    27781 ttgaataata atcaaacaat at
//
LOCUS       DAEHWM010000045        27458 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.046, whole genome shotgun sequence.
ACCESSION   DAEHWM010000045 DAEHWM010000000
VERSION     DAEHWM010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27458)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27458)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27458
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.046"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            45..896
                     /locus_tag="KNP36_002036"
     CDS             45..896
                     /locus_tag="KNP36_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfurtransferase"
                     /protein_id="HBF0873909.1"
                     /translation="MKNIISAKELISKLEKNDNLVVIDCRFDLINRTYGIDSYKKGHI
                     KGSFILDIDKDLSSPTKEHGGKNPLQDPLILKEKLEKMGVDNDTTIVTYDDGDLNGAC
                     RLFFQLKHLGLKNVYVLDGGITSFVKEGGELEEKVNIPSCTGKEIRPNINNDLVVPME
                     YVKSKLYKKDTVIIDCRANERYQGLVEPAYSKAGHIPSAKNYFCKDLIKSDFENGSLK
                     DIEFLKKFFKDLNNYDEVILSCGSGISACVNSLALRELDIPHKIYIGSFSDWISYDDN
                     EIKTGQE"
     gene            complement(1029..2642)
                     /gene="ggt"
                     /locus_tag="KNP36_002037"
     CDS             complement(1029..2642)
                     /gene="ggt"
                     /locus_tag="KNP36_002037"
                     /EC_number="2.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyltransferase"
                     /protein_id="HBF0873910.1"
                     /translation="MKFNAYQHKYSSIRNVVYAKNGAVATSTPLASQAGLEILKKGGN
                     AVDAAVATAATLAVVEPTSNGIGGDAYALVWIEEEKRLYGLNSSGFAPENMELKNYNN
                     MKEMPKYGFGAVTVPGIPAAWSELNKKYGKLSLMECLSPAINYAREGYVVSPNVAKVW
                     KKSYELYEKELIGEEFKPWFDTFSKDGKAPEAGDIFICEEQASTLEEIANTQAESFYR
                     GRLADKIDEYSKKFNGAIRKSDLECFYPTWVEPISTEYKGYKIFEIPPNGHGITVLMA
                     LNILKELELEGNIENVEDIHKIIESLKLAFADSKTYVTDIEHMKVKIQELLSQEYAKK
                     RSLLIDNKEALYPTAGEPYCGGTVYLCTADKDGNMVSYIQSNYINFGSGIVIPRTGIA
                     LHSRGNNFNLDPKHHNVVKPFKKPYHTIIPGFLGKEDKAIGPFGVMGAFMQPQGHIQV
                     LTNMIDFGLNPQEALDAPRWQWIKGKEIEVEPEMPKHIIDSLIEKGHEIKVIHDTVDM
                     GRGQIIFKTEQESYICGTESRCDGHIAVY"
     gene            complement(2867..4804)
                     /locus_tag="KNP36_002038"
     CDS             complement(2867..4804)
                     /locus_tag="KNP36_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873911.1"
                     /translation="MTLFRIAMQNVKNSFFNYLMYFISIVFSVFVFFSFKSIEYNEAL
                     SSLGEKTRMSINTSSIVIVVFVFLFIYYSNSFFFNRRRREVGTYSLLGMRKNQIGKIF
                     LYETFLMGIVAILIGIFLGLLFSKLMTMMLVKLMNEMIVVNMNLSIKALVQTLAVFLI
                     IFIVIGIRNTIVIRNKRIIELFNKYPEKYKFKKFIKLKCVLGVLLIAISYLMSISYFI
                     AENIMLSVFILVTIIPGTFLFFSSTMYMIIDAVKKRKSFYYKGQNLIAFSELGFKLKS
                     NSSVLAVIAILIATSVTMLGFTISLYYDIDRNISENYKYSYTINLGNSYVNNEIDKLL
                     YKYKKDNKIIFDKTIELIDKDINIEMYYKNGNSYIEDRTSVDIIRESDFKKLRQYQNN
                     NYEELTSKESVYYVSDSYKKIFFKDFEVEKINLHIKDTNEYDINLFKVQKSILEPEIN
                     SQATFDLIVAKDDVFNQLKLHGNSRLIRLIDIKNEKKELDLTLKLKNIVSENMKFTYP
                     FNFTSSIESYNNLIKLSGLMLFIGIFLSVVFLLCTGSIILFKQLSNIYDDKERYIMLI
                     KLGANNKDIEKIISKQLKVIFLMPLVVGTVHNLFAMSIAQKFIPRSLLVPIIITLVIY
                     FIGYFIYYFLTLKYALNMIKE"
     gene            complement(4791..5558)
                     /locus_tag="KNP36_002039"
     CDS             complement(4791..5558)
                     /locus_tag="KNP36_002039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003722224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873912.1"
                     /translation="MEEILSVENIKKEYGRKGSKHEALRGITFKVYKGEFVGIMGSSG
                     AGKSTLLNIISTIDLPSSGDIYINGKNTIKMKQNELADFRRDNLGFVFQDSNLLDTLT
                     IKENIMLPLSLKNERVSVIENRIKEISKELNIESILDKYPGEVSGGQKQRGAVCRAIA
                     TKPSLVLADEPTGALDSKSARDLLNCLLKLNKDSNKTILMVTHDAISASFCNRILFIK
                     DGIIFTEIVKGESNREFYNKIVNTVSLIGGVNKNDFI"
     gene            5846..6520
                     /locus_tag="KNP36_002040"
     CDS             5846..6520
                     /locus_tag="KNP36_002040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873913.1"
                     /translation="MFKIMVVEDDVSLKNIIAKCLTKWGHDVHQIENLENIIEEFKNY
                     NPELVLLDINLPFYDGFHWCNEIRKISKVPIIFISSRNSNMDVIMGVNLGADDYIQKP
                     FSVDVLVAKVNALLRRTYNFVDNNSNQIIHNGVTLDLSTATINYEDNTIELTKNEIKI
                     LHELMKYKGQIVSRNKLMKKLWDNDWFVDDNTLTVNVNRIRSKLNEIGLEDFIETKRG
                     LGYIIS"
     gene            6544..7548
                     /locus_tag="KNP36_002041"
     CDS             6544..7548
                     /locus_tag="KNP36_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0873914.1"
                     /translation="MSFKDFLKDKLGFLVYNFTFLIFTVSVIIFSPVDVFLTDTILYI
                     LVVNVVFLFLYLFISYIKKNKFLDKIKNDTFKINMNDIELARCKNEEKIYLNIIKNHQ
                     YQCNNIINNNIEKFEENKEILNMWVHDVKIPIAIIKLILEQNENLIDEKISDDIDSEI
                     FRIENSVEKILYLSRLEDFHKDFLIQEVNIEKIIRNIIKKYSKYFISKKIILDLNNLN
                     FKVLSDEKWLYFIFEQLLSNSLKYSSLGDNISIYCKRTKNYLQLRVEDTGCGIKKEDL
                     NRIFNKGFTGNNGRNNSKSTGLGLYLVKELCDKLGHKIDVDSEYNQYTKFTITFKCDL
                     "
     gene            7660..8889
                     /locus_tag="KNP36_002042"
     CDS             7660..8889
                     /locus_tag="KNP36_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HBF0873915.1"
                     /translation="MSFLKKFKNKRFRNNSFKSNNFRNSSFGSSGFKSKNKGFKNNPF
                     KNKRFKIYAGIAVIILLILGVLAYVDSKNTELQANENFIETYTIPENEKIFINGMVVP
                     KQTKDFNISGDYELSDVNVTNGQKVNQGDLLFTAKNPTIIAEIDSLKSQLSQYKKQKI
                     SLSDIAENKDAIASINAQITALSSQIASLDKKAYDRVTAPFDGTVYLNDQTGNPDQPV
                     SFMTIQGLEFYMKGQASEQDLPKMKIDQMVNILVFSTDQKLTGRISFISDKPSTPNTE
                     MGAQQNTLSYYDINIAFDNQEGLVNGFHLQASLEVANSSFKIPASCVLKDNKHSYVFK
                     DLDGILKKQIVDVASQNDDFAVVRGGLEQGDIIIKHPTKEMKEGDPVQGDGVTAGSNN
                     GDTTPNKKVEEVTMDVN"
     gene            8897..9571
                     /locus_tag="KNP36_002043"
     CDS             8897..9571
                     /locus_tag="KNP36_002043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873916.1"
                     /translation="MLIKLENIQKYYKVGKDELHVLKSLNLEIESGEFVMIMGKSGSG
                     KTTLLNILGFLDVFDEGRYIFDGTDVTNLSENERSVFRNINIGFVFQQFNLIETLNVY
                     QNVELPLIYNKALKKSNREEIVKDKLSSVGLLDKLKQKPLQLSGGQQQRVAIARCLAN
                     DPQIIFADEPTGALDSETSREIMELLTRLNKQGKTIIMVTHDQDLTKYATKVIRLKDG
                     VFTSEV"
     gene            9574..10806
                     /locus_tag="KNP36_002044"
     CDS             9574..10806
                     /locus_tag="KNP36_002044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873917.1"
                     /translation="MSLLKNSLANLKGHKLRVFVALLWIIIGITSVILVSSIGNGFQK
                     EIKKSVNNVNPNKTTISFESADNTGLTDDMSIFLKPFNAKDLEELSFVEGVERIAPSR
                     DGFNLDSVYSSQASFDKKTTYVDVGPVKKDSKINLICGRDFSLDDEKRKVILLTLQST
                     SEIFENPEDALGHGININGTIFEIIGVLDDSQQNQAGGFFGGYQDMQFTTSLVPKKAF
                     DTLMSQNSYSNEIYQLDLVSSKGYNVNEVANNVIAKLYEMHPGINGSYTTPDPTEQTA
                     YLESINSNVNKYVSIITVVAMFVGGIGVMNIMYVSVMERQREIGIRRAIGAKPRSILF
                     QFLVEAVFITVCGGILGTIVGFTATNYVSKYIGFEAIPSLNSLFYAIVATILTGVVFG
                     LIPAFKASKLDPIKAIYK"
     gene            complement(11092..12357)
                     /locus_tag="KNP36_002045"
     CDS             complement(11092..12357)
                     /locus_tag="KNP36_002045"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HBF0873918.1"
                     /translation="MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKI
                     IDASGNVVAPGLVDVHVHFRDPGFTYKEDIESGAKSAARGGFTTVICMANTNPIVDNE
                     DTFNYVKEKSKNACINVLQAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNL
                     IMEAMIKAKELDVPLSFHEEDPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCM
                     LALKTGAKVDIQHISSGVSVDMVRFAKYLGANVVAEASPHHFTLTEEDVLEFGTNAKM
                     NPPLRSKWDRDKIIEGLNDGTIEIIATDHAPHSKEEKDREFIKAPSGIIGLETSLALG
                     ITNLVHKNHLSMMQLIEKMSINPAKLYNLNIGFIEEGAVADIVIFNPEEEWTVESFVS
                     KADNSPFKGKSLYGKVNYTICNGEIVYNA"
     gene            complement(12410..13558)
                     /locus_tag="KNP36_002046"
     CDS             complement(12410..13558)
                     /locus_tag="KNP36_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF362 domain-containing protein"
                     /protein_id="HBF0873919.1"
                     /translation="MKSVSVRSCKTYNYEEVKLSIEKNLEDIGGIDKFVKKGSKVLIK
                     PNLLMKKKPEEATTTHPMVVKVVCEKLLELNCDITIADSPGGPYNQSSLKSIYKASGI
                     EEVANELGIKLNYDVSDVKIHSEKAHVLKYMDIIKPIVDSDYIINLCKLKTHIMATFT
                     GGTKNLYGCIAGLKKAEIHYRFPTEELFCENVLLDICDYIKPTLTIMDGIVGMEGDGP
                     SAGTTREIGVLLASQNPYAIDVVACKIISLLPNRVATIRGAIKRGYIQEDFSDIEILG
                     EDIKDLIIKNYKIPNVSKDLRLFSVKLPKFLNEPISKLITPKPVVRFQDCIKCGKCKE
                     ACPASTIEIGTKGAIIDLSKCIRCYCCHELCPKKAIDVKRNFVFKYVK"
     gene            complement(13649..14194)
                     /locus_tag="KNP36_002047"
     CDS             complement(13649..14194)
                     /locus_tag="KNP36_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH peroxidase"
                     /protein_id="HBF0873920.1"
                     /translation="MKKFVCTVCGYIHEGDAAPAQCPVCKVGADKFEEMKGEMVWADE
                     HRIGVAQGVDAEIIEGLRANFTGECTEVGMYLAMSRQADREGYPEVAEAYKRIAFEEA
                     EHAAKFAELLGEVVVADTKENLRVRVDAEYGATDGKLKLAKRAKELGLDAIHDTVHEM
                     CKDEARHGKAFLGLLNRHFGK"
     gene            complement(14417..15361)
                     /locus_tag="KNP36_002048"
     CDS             complement(14417..15361)
                     /locus_tag="KNP36_002048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBF0873921.1"
                     /translation="MQKNKKEGALLKKYFGEIGLIFIAIIWGSGFVATQFALDGGLTP
                     LQIITLRFFLAAIIMNLLFFKQIRANMGKKLLKAGGILGIFLFLAFTVQTIGLMYTTP
                     SKNAFITAANVVIVPFIGFILYRRKLDKIGIISSLVALIGIGILSLEADFSINFGDFL
                     TLICSFGFAFHIFFTSEFAKDNNPMALTAIQFTVAFLMSVVVQTFAGQLKMEAELSGY
                     MGTMYLAVFSTTIGFLFQTICQKRVDGTRTAIILSTEAVFGTIFSIIILKELITAKLV
                     IGSILIFVAIITAETKLSFLKSKKVKLKDSEESSLESI"
     gene            15747..16628
                     /locus_tag="KNP36_002049"
     CDS             15747..16628
                     /locus_tag="KNP36_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="HBF0873922.1"
                     /translation="MVKKRKKKTVTLTILVVIVIGIFSMAWADMSRKKEMKETQERLK
                     AERLEKERIEKEKNEPIIGAKKEAVKEYGYDAKIVWDKLNKYDYSNNGEKIVFLTFDD
                     GPSTTNTPQVLDILKRHGVRGTFFIKGDSLERKGANEILKRTFDEGNAIAHHSYTHDY
                     KKLYPNRSLNLDTFVNELNKTDEAMKKVLGKNFSSNVVRCPGGYMSWKNMEPLGNYLK
                     EKNMASIDWNALNADAEGKKKNAQELFEHAKKSSEGKEMVVLLMHDTYGKQETVNALD
                     QIITYFKDNGYQFKILI"
     gene            complement(16689..17897)
                     /locus_tag="KNP36_002050"
     CDS             complement(16689..17897)
                     /locus_tag="KNP36_002050"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HBF0873923.1"
                     /translation="MKSIDEQMRIIMKGVDDLIDEKELREKLIKSEKEGKPMIVKLGL
                     DPSAPDIHLGHTVVLRKMKQLQDLGHQIVIIIGDFTGKIGDPTGKSKARKALTTEQVL
                     ANAKTYEEQIFKVLDKEKTIVRFNSEWLAKLNFEDVIKLAATITVARMLEREDFKKRY
                     EGQMPISVHEFFYPLMQAYDSIALEADIELGGTDQRFNLLMGRSLQREFGMESQIVIM
                     MPLIEGLDGKEKMSKSLGNYIGIDEEAGIMYQKSMEIPDELIIKYYNLVTDVHPDEVN
                     KIESQLKEGSVNPRDIKMNLAREIVTLYHGEESAKEAEERFKSVFQKGQIPEDIQTIQ
                     VKEDGFDLIEVLVSNEIVKSKSEVRRLASQGGVKVNGEKVEDLSTIVKESELVVQIGK
                     KKFVKIELVK"
     misc_binding    complement(17970..18222)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(18374..19363)
                     /locus_tag="KNP36_002051"
     CDS             complement(18374..19363)
                     /locus_tag="KNP36_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2232 domain-containing protein"
                     /protein_id="HBF0873924.1"
                     /translation="MIYGGSVLNTTKKLTEAALLSSLFIVVTIIAVSTGFGYAIYLDF
                     IVPVFFCIICLKCDLKYTILSGITSLLIISLVLGNLGTAIWASQSVLLGIMCGYLINK
                     PTMVMDDLVYGSVFGLIVMVFIDIYASTLIGYSFMKEFQGYSKWIYFNGYTNFIYYLM
                     IALFPFGMVFCIYLLSLILGNKLHILDSNSLKKFLIFKNFRSLNQFLCCSKKAFYICV
                     SYLAIFEVLKLLNVKVDSVYLKTIFISITYISLYFIIRDSCMSLQNFIIAKFRKLLYA
                     RILFLIIILLLFFIFDVTVIGLIIINAFLNKKINIRLSQSNIVNKQINLLIEK"
     gene            19515..19955
                     /locus_tag="KNP36_002052"
     CDS             19515..19955
                     /locus_tag="KNP36_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0873925.1"
                     /translation="MFKIKHFNDLSLDEFYEIAKSRYEVFACEQKIFSLNDYDDIDKN
                     SYHIFLKENGLICAYARIIPKEYSSYNDVSIGRVLVLSSHRRKGLAKQMMDCAIDFIK
                     VNLHENNITLSAQTYIKNLYLSCGFKEISEVYDEAGIEHIKMRL"
     gene            20282..20509
                     /locus_tag="KNP36_002053"
     CDS             20282..20509
                     /locus_tag="KNP36_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBF0873926.1"
                     /translation="MKNLNDIQVKKTVKVEDILSSGNLRERMLALGLTRGAVIDVVRK
                     GPKNNLTVYKIRGSKIALRQEESSLILVSDI"
     gene            20535..22655
                     /gene="feoB"
                     /locus_tag="KNP36_002054"
     CDS             20535..22655
                     /gene="feoB"
                     /locus_tag="KNP36_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBF0873927.1"
                     /translation="MGLTHNSTKMSSLKDMFDIDNKEDQFVIALAGNPNTGKSTVFNH
                     LTGLRQHTGNWPGKTVATARGNFKYKNTEYALIDLPGTYSLFALSQEEIVARDFICFG
                     NPDAVIVVCDATCLERNLNLVFQVMELTDKVILCINLIDEARKKGITIDKKLLEDSLG
                     IPVILTAARNGSGMDELLDTLNDVSFDKYKLNNKPVRYNENIENVVKSIQPELDNIIP
                     GINSRWLGLRLIDGDESIFESMSNYIDKNSIDAINEVKKKIPDNINKQKIRDEFTKIN
                     YDYAKKLSDECCSNVAKKSTDREEKVDKILTSKIFGLPIMLLLLGTILWITIEGANYP
                     STLLSNLLLGFEPSISGILNSINCPSWLNDMLVLGLYRTLAWVISVMLPPMAIFFPLF
                     TLLEDFGYLPRVAFNLDHLFKKACAHGKQCLTMCMGFGCNAAGVIGCRIIDSPRERLI
                     AILTNNFVPCNGRFPTLIAISTIFFSSVITNSFVSSVATALCITLLIILGVIITLLVS
                     YTLSKTLLKGVPSTFTLELPPYRVPQIGRTLYTSIIDRTIFVLGRAVMVAIPAGVITW
                     IFANIYIGDLSILSHVANFLDPLAKLIGLDGFILLAFILGFPANEIVVPILLMAYLAT
                     GSMIELDSFSALGQVLREHGWTYLTALNVMLFSLLHWPCATTLLTIKKETGSLKWTAL
                     GFLMPTILAFVVCFLTTTVYNLFI"
     gene            complement(22788..23606)
                     /locus_tag="KNP36_002055"
     CDS             complement(22788..23606)
                     /locus_tag="KNP36_002055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0873928.1"
                     /translation="MEKQYFTTGEFAKLCGISKQTLIFYDKIGIFSPEYKDKNNYRYY
                     SVYQYDTLDILQSLREIGMSLEEIKEYIQNRTPQLCVKMLKEEEKKIREKIKKLRKIS
                     SKMQNRINITVEGISKMNSEEIYISKKFEEYLVLSSDLSNMSNSDFMMELIDFTNYCK
                     SKNLYQGYELGVIVSNENIKNGDYLSISSFYLKIDKKIKDKKLYVKPEGMYACIKHIG
                     KYEDSYKSYEKLKKYIYENEYKIVGNSYEESILDFFCESNEDNYMTEISIQVSR"
     gene            23813..24097
                     /locus_tag="KNP36_002056"
     CDS             23813..24097
                     /locus_tag="KNP36_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873929.1"
                     /translation="MLVRVKIVIGATIRYLIKHKVNYCNKKSLDKLELKYGNIDREKA
                     VKLEIFYQYLIELEYIEMSLLIRRLDTAITSLALVSIITIASYYLIRKNV"
     repeat_region   24265..24491
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=24332..24360
                     /rpt_unit_seq="atttacattccatatagttaatataaaac"
     gene            complement(25150..27243)
                     /locus_tag="KNP36_002057"
     CDS             complement(25150..27243)
                     /locus_tag="KNP36_002057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0873930.1"
                     /translation="MNKHNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPE
                     GKVCWQVLYPEKNSTCSFCKVLELLKNDKKGVLIKWYEKCNKLNRVFENYDSLITWQD
                     GTVVHMHQSIDIANSTSLNKPIKINEFHEISNNKEEKGVFNFSRDNFDYNSTLLYDAL
                     IRGTDEYIYICNMKTGVFRYSPSQVELFDLPGEIVKNPLVYWKKIVHPEDWNRFYKSN
                     TEIGKNQMDYHTVEFRAKNRSGEYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKID
                     SLTQLLNYHEFMSVFEDKISNPMIEKLCIVLLDIDDFKNVNEMYDRDFGDNIIKTLAQ
                     SVQSILPDNAELYKLDGDEMGILVDNVEENEILTLYNQIQNMIIHLQLWRKYGLNITI
                     SAGCVIYPKHGDTVKELYKCASYSLQYAKEHGKNRLVFFSQEILKNKMYSLEMMRDLK
                     ASINDDFRGFSLRFQPQVDTESHKIIGVEVLLRWTNDKCKAISPLEFIPILEENDMIN
                     IVGAWVLRMALRTFRKWIDYYPFFKVSVNVSAVQILEDTFIEDIVKIIDDENFPYQNL
                     VLELTESHTVQNMSILQFKFKALQDLGIYIAMDDFGTGYSSLEVLKFSPIDIVKIDRV
                     FVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVETQEEYDLVKQIKPDYIQGYLFGK
                     PQTATEIFDLLKLDN"
BASE COUNT         9664 a         4181 c         3372 g        10241 t
ORIGIN      
        1 tataaattaa aataaagata atataaacac aggaggtaca ttctttgaaa aacattattt
       61 cagcaaaaga acttatatca aaactagaaa aaaatgataa tctagttgta atagattgta
      121 gatttgatct tatcaataga acttatggta ttgattctta taaaaaagga cacatcaaag
      181 gcagttttat cttagatata gacaaggatt tatcatctcc tacaaaagaa catggtggta
      241 aaaatccttt acaagaccct ttaatactaa aagaaaaatt agaaaaaatg ggtgttgata
      301 atgacactac gattgtaact tatgatgatg gagatttaaa tggagcttgc agattatttt
      361 tccaattaaa acatttgggg cttaaaaatg tctatgtact agatggggga ataacatctt
      421 tcgtaaagga aggtggagaa ttggaagaga aagtgaatat accaagttgt acaggtaagg
      481 aaattagacc aaatataaac aatgatttag ttgttccaat ggaatatgtt aaatctaaat
      541 tatacaaaaa agatactgta ataatagatt gccgtgctaa tgagagatac cagggtttag
      601 ttgaacctgc ttactcaaaa gctggtcata taccaagtgc aaaaaattat ttttgtaagg
      661 atttaataaa aagtgacttt gaaaatggct cacttaaaga tatagaattt ttaaaaaaat
      721 tctttaaaga tttaaataat tatgatgaag taattttatc ttgtggttca gggatatctg
      781 cttgtgttaa cagtcttgct cttagagaac tggatatacc tcacaagatt tatattggta
      841 gctttagtga ctggattagt tatgatgaca atgaaatcaa aactggtcaa gaataaggct
      901 cataatctat ataaaatcag catatgatag cttaaatttt gtaaaggcgt cagtcattgt
      961 agactttcgc ctttacttat tatttcatat actctttaaa tttattatat atattttagt
     1021 tgataatatt aataaactgc aatatgacca tcacatcttg attccgtccc acaaatataa
     1081 ctttcctgtt ctgttttaaa tattatttga cctcgtccca tgtcgacagt atcatgaatt
     1141 acttttattt catgaccctt ttcaattaat gaatctatta tatgctttgg catctctggt
     1201 tcaacttcta tttcttttcc ttttatccac tgccatcttg gagcatctag cgcctcttgt
     1261 ggatttaatc caaaatcaat catatttgtt aacacttgaa tatgtccttg tggttgcata
     1321 aaagctccca ttacaccaaa tggacctatt gctttatctt ctttacctaa aaatccaggt
     1381 attatagtat gataaggttt tttaaatggt tttactacat tgtggtgttt agggtctaaa
     1441 ttaaaattat ttcctctact atgtaaagca atcccagttc ttggtatcac aattcctgaa
     1501 ccaaaattta tgtaattgct ctgtatatat gaaaccatat ttccatcctt atctgcagta
     1561 caaaggtata ctgtaccacc acaatatggc tctcctgcag ttggatacaa agcctcttta
     1621 ttgtcaatca ataaacttct ttttttagca tactcttggc ttagtaattc ctgaatcttt
     1681 accttcatat gctctatatc agttacatat gttttagaat ctgcaaaagc taattttaaa
     1741 ctctctataa ttttatgtat gtcttctaca ttttctatat ttccttctaa ttccaattct
     1801 tttaatatgt taagtgccat taaaactgtt attccatgac catttggtgg gatttcaaat
     1861 attttatatc ccttatattc tgtacttata ggttctaccc atgttggata aaaacactct
     1921 aagtcactct ttcttatagc cccattaaat tttttagaat attcatctat tttatcagca
     1981 agtcttcctc tataaaagct ttcagcctga gtatttgcta tctcttctaa tgtacttgcc
     2041 tgttcttcac atataaatat atctccagcc tctggagctt taccatcttt agaaaatgta
     2101 tcaaaccatg gtttgaactc ttctccaata agttcttttt catagagttc atatgatttt
     2161 ttccatacct tagctacatt aggagatact acgtatccct ctcttgcata gtttatcgct
     2221 ggagataagc attccattaa gctaagttta ccatattttt tatttaattc tgaccaagct
     2281 gctggtattc caggtacagt tactgctcca aacccatatt ttggcatttc tttcatatta
     2341 ttataatttt ttaattccat attttctgga gcaaagccac tagaatttaa accatacaat
     2401 cgtttttctt cctctatcca aacaagggca tatgcgtctc ctccaatccc attgcttgta
     2461 ggttctacta ctgctaatgt ggcggctgtt gcaactgctg catcaacagc atttccaccc
     2521 ttttttagta tttcaagtcc agcttgagat gctaatggtg ttgatgttgc aactgctcca
     2581 tttttagcat acacgacatt tcttattgat gagtatttat gttggtaggc attaaacttc
     2641 ataaatttca gctcctcgtc attttttatt tgatattctg cttagattta ttatataaca
     2701 tcaagtaatg taactgatac aaaatgatat aaaatataga ctttttccta actttaattt
     2761 tgtctttaaa taaatatctt aaactcaatt ctagtatttt ctatctgcac ttaaataagt
     2821 tattttattc aaaacatata tctaattctt ttgacttaaa aataatttat tcttttatca
     2881 tgtttagagc atattttaaa gttaaaaaat aatatataaa atatcctata aaataaatga
     2941 ctagagttat gataattggt acaagtaatg accttggtat aaacttttgt gctatagaca
     3001 tagcaaataa attatgaact gtacctacaa ctaatggcat taaaaatata acttttaact
     3061 gttttgatat tattttctca atatctttat tatttgctcc aagttttatt aacataatat
     3121 atctttcctt atcatcatat atatttgata attgtttaaa taagattata ctacctgtac
     3181 ataaaagaaa tactacagac aaaaatatgc ctataaacag cattagacca cttaatttta
     3241 tcaagttatt ataactttca atacttgatg taaaattaaa aggataagta aatttcatat
     3301 tttcacttac tatatttttt aattttaaag tcaaatccag ttcttttttt tcatttttta
     3361 tatcaattaa tcttattaat ctagaatttc catgtaattt taactgatta aatacgtcat
     3421 cttttgctac aattaaatca aacgtagctt gtgaatttat ttctggctcc aagatgcttt
     3481 tttgtacttt aaacagattt atatcatact catttgtatc tttaatatgc aagtttattt
     3541 tttcaacctc aaagtcttta aaaaatattt ttttgtatga atcagaaaca tagtacacag
     3601 attcctttga agttaattct tcataattgt tattctgata ttgtcttaat tttttaaaat
     3661 cactttctct aataatatct acagacgttc tatcttctat ataactattt ccatttttat
     3721 aatacatttc aatatttata tctttgtcta taagttctat tgttttatca aagattatct
     3781 tattatcttt tttatattta tataataatt tgtcaatttc gttatttaca taagaatttc
     3841 ctaaatttat ggtataactg tatttataat tttcacttat gttcctatct atatcgtaat
     3901 aaagtgatat ggtaaaccct agcatagtta cacttgtagc tattaatatt gctattacag
     3961 ccaatacact actattgctc tttaatttaa atccaagttc agaaaatgca attaaattct
     4021 gtcccttata ataaaaactt tttctcttct taacagcatc aataatcata tacatcgttg
     4081 atgaaaaaaa taaaaaagtt ccaggtatta ttgtaactaa tataaaaact gaaagcataa
     4141 tattttcagc aataaaataa ctaattgaca ttaaataaga aatagctatt aataaaacac
     4201 caagtacaca ttttaacttt ataaattttt taaacttata cttttctgga tatttattaa
     4261 ataactctat aattctctta tttctgataa ctatagtatt tcttattcca ataactatga
     4321 atattattaa aaataccgct agtgtctgaa ctaaggcctt tatacttaag ttcatattta
     4381 ctactatcat ttcattcatt aattttacaa gcatcatagt cataagcttt gaaaataaca
     4441 gtcctaaaaa tatacctatt agtattgcaa ctatacccat caaaaaagtt tcatataaaa
     4501 atatttttcc tatctgattt ttcctcattc caagtaaact ataagttcct acttctcgcc
     4561 tacgtctatt gaaaaaaaat gagtttgaat aatatataaa taaaaataca aataccacta
     4621 ttacaattga acttgtatta atactcatcc tagttttctc tccaagtgaa ctcaacgctt
     4681 cattatactc tatagattta aaactaaaaa atacaaatac actaaataca attgaaataa
     4741 agtacattaa ataattaaaa aaactattct ttacattttg cattgcaatt ctaaataaag
     4801 tcatttttat taactcctcc aattaaggaa actgtattta ctattttatt atagaactct
     4861 ctgttacttt ctccctttac aatttctgtg aatattattc catcctttat aaagagtatt
     4921 ctattgcaaa aactcgcact tatagcatca tgagttacca tcaatattgt tttattgctg
     4981 tctttgttta attttaatag acaattcaac aaatccctag cagatttaga atctaatgct
     5041 cctgtaggct catctgcaag tactaatgat ggttttgttg ctatagctct acatacagct
     5101 cctctttgct tttgtccacc agaaacttcg ccagggtatt tatctaatat agattctata
     5161 tttaattctt ttgaaatctc ttttattcta ttttctatta ctgatactct ttcatttttt
     5221 aaagaaagag gcaacattat attttctttt attgtaagtg tatccaaaag attagaatct
     5281 tgaaatacaa agcctagatt atcacgtcta aaatctgcca attcattttg cttcatttta
     5341 atagtattct ttccatttat ataaatatct cctgatgaag gtaaatctat tgtagaaata
     5401 atatttaaaa gtgttgattt accagcaccg gaagacccca taataccaac aaattctcct
     5461 ttataaacct tgaaagttat tcctcttaga gcttcatgtt ttgaaccttt tcttccatac
     5521 tcctttttta tattttcaac agataatatt tcttccatag ttaataatca cctttcatca
     5581 caattagtta tttatcaatt ctcacaaata tattatatat attaaaatgg cttttaaaca
     5641 tttaattata ttaatttaag gttacatttt cgtaagtatt aattatattt cttcaaattt
     5701 attgcaatta tgtttaaaat ataatttatc aagtaaaata tagttatatt aatataatta
     5761 ttttaggtaa taaggtagaa atattttaat ttatcaagta gaatatagtt atgttaatat
     5821 aactattttg aattaggagg taagaatgtt taaaataatg gtagttgaag atgacgtctc
     5881 attgaaaaat atcatagcaa agtgtcttac taaatgggga catgatgttc atcaaataga
     5941 aaatcttgaa aatataatag aagagttcaa aaactataac ccagaattag ttttattgga
     6001 cataaacctt ccattttatg atggttttca ttggtgtaat gaaataagaa aaatttcaaa
     6061 agttcctata atttttattt cttcaagaaa ttctaatatg gatgtaataa tgggtgtaaa
     6121 tttaggtgca gatgattata tacaaaaacc tttttctgta gatgtcttag tagctaaagt
     6181 taatgccctt ttaagaagaa cttataattt tgttgataat aactcaaatc agattattca
     6241 caatggtgtt actttagatt tatcaactgc aacaataaac tatgaagata atactattga
     6301 gctaacaaaa aatgaaatca aaattcttca tgagcttatg aaatataagg ggcagatagt
     6361 aagtaggaat aaactcatga aaaaattatg ggataatgat tggtttgtag atgataatac
     6421 attaactgtc aatgtaaata gaatacgctc aaagttaaat gaaattggtt tagaagattt
     6481 tatagaaaca aaaagaggat tgggttatat aatcagttaa aacaattcta agtaggtgaa
     6541 tttatgagct ttaaagattt tctcaaggat aaactaggtt ttttagtata caattttact
     6601 ttcttaattt ttacagtatc agttattata ttttctcctg tagatgtttt tctgactgat
     6661 actattttat atatattagt tgtaaatgtt gtgtttttat ttttatatct atttattagc
     6721 tacatcaaga agaacaaatt tttagataag ataaaaaatg atacattcaa aattaatatg
     6781 aatgatatag aattagctag atgtaaaaat gaagaaaaaa tatacttgaa cattattaaa
     6841 aatcatcaat atcaatgtaa taacataata aataataata tcgagaaatt tgaagaaaac
     6901 aaagagattt taaatatgtg ggtacatgat gtaaagatac ctatagctat aataaaactc
     6961 attcttgaac aaaatgaaaa tttaattgat gaaaaaattt cagatgacat agatagtgaa
     7021 atatttagaa ttgaaaactc cgttgaaaaa attttatatt tatcaagact cgaagatttt
     7081 cataaggatt ttttaattca agaggtaaat attgaaaaaa tcattagaaa tattataaaa
     7141 aaatactcaa aatattttat ttcaaaaaaa attattttag acttaaataa tttgaatttt
     7201 aaggttttat ctgatgaaaa atggctatac ttcatattcg agcaattatt gagtaattcc
     7261 ctaaaatact cctcattagg agataatata tctatctatt gcaaaagaac caaaaattat
     7321 ttacaattaa gagtggaaga tactggttgt ggtataaaaa aggaagattt aaatcgaata
     7381 ttcaataagg gatttacagg taataatgga agaaacaatt ctaaatctac aggtcttggg
     7441 ctttatttag taaaagaact ttgtgataag cttggtcata aaattgatgt agattcagag
     7501 tacaaccaat atacaaaatt tactattaca ttcaaatgtg atttatagta tcttattatt
     7561 gatagtttat tttcattaac ttatattcaa cttcttatag taattctata tgtacatccc
     7621 agtatataat taagtagttt ttataaaaag gaggaagaca tgtcttttct aaaaaaattt
     7681 aaaaataaaa gatttagaaa taacagtttt aaaagtaaca actttagaaa tagcagtttt
     7741 ggaagtagtg gcttcaagtc taaaaataaa ggttttaaaa acaatccctt taaaaataag
     7801 agattcaaaa tatatgcagg aatagcagta atcatacttt taattctagg agttcttgct
     7861 tatgttgatt cgaaaaacac tgaattacaa gctaatgaaa attttatcga aacatatact
     7921 attcctgaaa atgaaaaaat atttataaat gggatggttg ttcctaagca aactaaggac
     7981 ttcaatatat ctggagatta tgagttaagt gatgttaatg ttacaaatgg tcaaaaagta
     8041 aatcaaggag accttctttt tactgctaaa aatccaacta taatagcaga aatagatagt
     8101 ttaaaatcac aacttagtca atacaaaaaa caaaaaatat cactttctga tattgctgaa
     8161 aataaagatg ctattgcttc tataaatgca cagataactg ctttaagctc ccagatagct
     8221 tctctggata aaaaagctta tgacagagtt actgctcctt ttgatggcac agtatacttg
     8281 aatgaccaaa ctggaaatcc agaccaacca gtttcattta tgactattca aggtctagag
     8341 ttttatatga aaggacaagc aagtgaacaa gatttaccta aaatgaagat tgaccaaatg
     8401 gtcaatatac tagttttttc aactgaccaa aagcttactg gtagaataag ttttatatct
     8461 gataaaccat ctactccaaa tactgaaatg ggagctcagc agaatacact atcttattat
     8521 gatataaaca tagcatttga taatcaagaa ggattagtaa atggattcca tcttcaagca
     8581 tcacttgaag tagctaattc aagctttaaa ataccagcat cttgtgtact taaagacaac
     8641 aaacactcat atgtatttaa ggatttagat ggtatattga aaaagcaaat tgtagatgta
     8701 gcaagtcaaa atgatgattt tgctgtagtt agaggcggtc ttgaacaagg cgatataata
     8761 ataaaacacc ctactaaaga aatgaaagaa ggagacccag ttcaaggcga tggcgtaact
     8821 gctggttcta ataatggaga tactactcca aacaaaaaag tagaagaagt tactatggat
     8881 gtgaattaat ttacatatgt taattaaatt agaaaatatt caaaaatatt acaaagtagg
     8941 gaaagatgaa ttacatgttt taaaatcctt aaatttagaa attgaatctg gagaatttgt
     9001 catgataatg ggtaagtctg gtagtggtaa aactacttta cttaatatct taggttttct
     9061 agatgtattt gatgaaggaa gatatatatt tgatggaaca gatgtaacta atttgagtga
     9121 aaatgaacgt tctgttttta gaaatattaa tattggattt gttttccaac aatttaattt
     9181 aatagaaact ctaaatgtat atcaaaatgt agagttgcct ctaatttaca ataaagcact
     9241 aaaaaaatct aatagagaag aaattgttaa agataaatta agttctgttg ggcttttgga
     9301 caagcttaag cagaaaccac ttcaattatc tggtggtcaa caacagcgtg tagccattgc
     9361 acgttgccta gcaaatgacc ctcagataat ctttgctgac gaaccgactg gggcattaga
     9421 tagtgaaact agcagagaaa ttatggagct tttaacaagg ctcaacaaac aaggtaagac
     9481 tataataatg gttacacatg atcaagattt aactaagtat gcaactaagg ttatacgact
     9541 taaagatggt gtgtttactt cggaggtgta atcatgagtt tattaaaaaa ttctttggcc
     9601 aatttaaaag gtcacaagct tcgtgtattt gtagctttac tctggattat aataggaata
     9661 acttcagtaa tacttgttag ttctataggt aatggatttc aaaaagaaat taagaaatct
     9721 gtaaacaatg taaaccctaa taaaactact atttcgtttg aatcagccga taacacaggt
     9781 cttactgatg atatgagtat ttttttaaaa ccatttaatg caaaagattt agaagaatta
     9841 tcatttgttg aaggagtaga aagaatagct ccttcaagag atgggtttaa ccttgattca
     9901 gtttactctt cacaagcatc ttttgataaa aaaactacgt atgttgatgt tggaccagta
     9961 aaaaaagatt ctaaaataaa tttaatttgt ggtagagatt tttctttaga tgatgaaaaa
    10021 agaaaagtaa ttttacttac attacaaagt acaagtgaaa tttttgaaaa tccagaagat
    10081 gccttaggtc atggtatcaa cataaatgga actatatttg aaataatagg ggtattagat
    10141 gattctcagc aaaaccaagc tggaggattc tttggaggtt accaagatat gcaatttact
    10201 acttccctag tacctaaaaa ggcttttgac actttaatga gtcaaaattc ttattcaaat
    10261 gaaatttacc agttagactt agtttcttct aaaggctata atgtaaatga agttgcaaac
    10321 aatgttatag ctaaattata tgagatgcac cctggtatca atggttctta tactacacca
    10381 gacccaactg aacagacagc ttatcttgaa agcattaatt ccaatgtaaa caaatatgta
    10441 tctataataa ctgtagttgc aatgtttgtt ggtggtattg gtgtaatgaa tataatgtat
    10501 gtatctgtta tggaaagaca aagagaaatt ggtataagac gtgctattgg agcaaaacct
    10561 aggtctatat tatttcaatt tttagttgaa gctgttttta taacagtatg tggtggaatt
    10621 ttaggaacta tagttggatt tactgctact aactatgttt ctaaatatat aggttttgaa
    10681 gctataccta gcttaaatag cttattttat gcaattgtag ctactatatt gactggagtt
    10741 gtatttggtc tgattccagc ctttaaagcc tctaaactag accctataaa ggcaatttat
    10801 aagtagaaat tgtataaaga ttttcgattt ttagattagt ttatataaaa catacttaaa
    10861 tatataacgc actattatat atgatagatt aggaacttaa tctttccaaa tataatagtg
    10921 cgttctttca taaaaaggat tctcttcctt actatatcta aattaccaag atgttatgtt
    10981 ctaattgttc aaactaatac ttccaatttt gattaatcaa tctcattctc ctaatataca
    11041 atcttttact ttcaatcatt gtacactccg cctaaaaaaa ataatcttaa attaggcgtt
    11101 atatacaatc tccccattac atattgtata attaaccttt ccatataaag atttaccttt
    11161 aaatggtgaa ttatcagctt tagaaacaaa gctttcaact gtccattctt cttctggatt
    11221 gaatataaca atgtctgcta cagccccttc ttctataaat ccaatattta aattgtacaa
    11281 ctttgcagga tttatagaca ttttttctat taactgcatc atactaagat gatttttatg
    11341 caccaaattt gttattccaa gagctaaaga agtttcaagc ccaataattc cacttggagc
    11401 ttttataaac tctctatctt tttcttcttt actatgaggt gcatggtccg ttgctattat
    11461 ttcaatagta ccatcattta atccctctat aatcttatct ctgtcccatt tacttcttag
    11521 aggtggattc atttttgcat ttgttccaaa ctccaataca tcttcctcag tcaatgtaaa
    11581 gtgatgtggt gaagcttctg caactacatt tgcacctaag tattttgcaa atctaaccat
    11641 atcaacagat acacctgaac ttatatgttg tatatcaact ttagcaccag tctttagtgc
    11701 caacatacaa tctctggcta ccataacatc ttctgctaca cttgatgcac cttttaatcc
    11761 aagttctgaa gctacctttc ctgcatttac acctggattt ccaactaaag aagggtcttc
    11821 ttcatgaaaa ctaagtggta catccaactc ttttgcctta atcattgcct ccataattag
    11881 attgctatcc attaaaggta atccatcatc agtaaaccct ggtacaccag cttttttaag
    11941 agcttccata tcaactaact ctttaccttc aaaaccttta gttatagctg ctgcttgtaa
    12001 aacatttata catgcatttt ttgacttttc tttaacataa ttaaaagtat cttcattatc
    12061 tacaatagga ttagtatttg ccatacatat aacagttgta aatccacctc tagcagcaga
    12121 tttagctcca ctttctatat cttctttata tgtaaaccca gggtctctaa agtgtacatg
    12181 tacatccact aaacctggag caactacatt accactagca tctattattt tttcatattc
    12241 atcactttca tcaaacttgc ctattttata aattttattt tcttttataa ttaagtcaat
    12301 attctcatct ctttgacttt tagggtctat tactctacca tttttaatta aaatcatatt
    12361 atttctcctt tatattttta atttatatag actcatataa tattatacat tattttacat
    12421 acttaaatac aaaattacgt ttgacatcaa tagccttttt aggacaaagt tcatggcaac
    12481 agtaacatct tatacattta cttaagtcta taatagcacc cttagtccct atctctatag
    12541 tggatgcagg acaagcttcc ttgcattttc cacattttat gcaatcttga aatcttacca
    12601 caggctttgg tgttataagc tttgaaatag gttcatttaa aaattttggt agctttacag
    12661 aaaacaatct taaatcctta cttacatttg gaatcttgta attttttata attaaatctt
    12721 ttatatcttc acctaaaatt tcaatatctg aaaaatcttc ttgtatatat cctctcttaa
    12781 tagcacctct aattgtagca actctatttg gaagtaaact tataatctta catgcaacaa
    12841 catctatagc atatggattt tgtgatgcta ataaaacgcc tatttctcga gtagtaccag
    12901 ctgaaggtcc atcaccttcc atacctacta taccatccat aattgtcaat gttggtttta
    12961 tataatcaca aatatctaaa agtacatttt cgcaaaacaa ctcttctgta ggaaatctat
    13021 aatgtatctc tgcttttttc aatccagcta tgcatccata taagtttttt gtaccaccag
    13081 taaaagttgc cattatatga gtctttaatt tacaaagatt tattatataa tctgaatcta
    13141 ctattggttt aataatatcc atatatttta gaacatgtgc tttttcacta tgtatcttaa
    13201 catctgaaac atcataattt aacttaatgc ccagttcatt tgctacttct tcaattccag
    13261 atgccttata aatgctctta agagaacttt gattatatgg accaccaggg ctatctgcta
    13321 ttgtaatatc acaatttaac tctaaaagtt tttcacatac aacttttaca accataggat
    13381 gtgtagttgt agcttcttca ggcttttttt tcattaataa atttggtttt ataagtactt
    13441 tgcttccttt tttaacaaac ttatctatac caccaatatc ctctaaattt ttttcaatag
    13501 ataactttac ttcttcataa ttgtaagttt tacaactcct aacagatacc gacttcatat
    13561 tatctccatc cttctatcac aacagtttat ttgtataatt taaaaaagga gaaaccaaag
    13621 tttctccttt taatctatgt tttaattatt attttccaaa atgtctgttt aataatccta
    13681 agaatgcttt accatgtcta gcttcgtctt tacacatttc atgtactgta tcatgtatag
    13741 catctaatcc taattcttta gctctcttag ctaattttaa ttttccatca gttgcaccat
    13801 actcagcatc aactctaact cttaagtttt cttttgtatc tgcaactaca acttctccaa
    13861 gaagttctgc aaatttagca gcatgttcag cctcttcaaa agctattctc ttatacgctt
    13921 cagctacttc tggataacct tctctatcag cttgtctact cattgctaaa tacattccta
    13981 cttctgtaca ctcaccagta aagttggctc ttaatccttc gattatttct gcatctacac
    14041 cttgagctac tcctattcta tgttcatcag cccaaaccat ttcgcctttc atttcttcaa
    14101 atttatcagc tccaacttta catactggac attgtgctgg tgcagcatct ccttcatgta
    14161 tatatccaca tactgtacaa acaaattttt tcataattaa tttcctccca attttatata
    14221 attaaatttt tatttttaag tttaataact tgctacaaga atatatatac cccagacttt
    14281 atagcttaaa cactaaaaat aaaatttatt tcctaattaa ttttatcact ttgaaacacc
    14341 agtatcaacc aagttttgat gtcaaatttc tacataatac ataatttatt tgattaatta
    14401 ggaaatagtt gtcatattaa atactttcta atgaagactc ctctgaatct ttaagtttca
    14461 cttttttgct ctttaaaaaa gataatttag tttctgcagt tatgattgca acaaatatca
    14521 agatactacc aataaccaat tttgctgtaa taagctcctt taaaattatt atagaaaata
    14581 ttgtaccaaa tacagcctct gtggataata ttatagctgt tctagttcca tcaactcttt
    14641 tttgacatat agtctgaaat aaaaatccaa ttgtagtact aaatacagct agatacatag
    14701 ttcccatgta accagataat tcagcttcca tctttaattg acctgcaaat gtttgaacta
    14761 caacagacat taaaaacgct actgtaaatt gaatagctgt caatgccatt gggttgttat
    14821 cttttgcaaa ctcacttgta aagaatatat gaaatgcaaa tccgaatgaa catataagtg
    14881 ttagaaaatc tccaaaatta atagagaaat cagcttctaa agaaagtatc ccaattccta
    14941 taagagctac caaactactt attattccta ttttatcaag ttttcttcta taaagtataa
    15001 atcctatgaa tggaactatt acaacattag ctgctgttat aaacgcattt ttagatggtg
    15061 tagtgtacat aagtccaata gtttgtactg tgaatgctag aaataaaaat attcctaaaa
    15121 tccctcctgc ttttaataat tttttaccca tattagcacg aatctgttta aaaaacagta
    15181 aattcataat tatagctgcc aagaaaaatc ttaaagttat gatttgtaga ggtgtaagcc
    15241 caccgtctaa tgcaaattgg gttgctacaa agccacttcc ccatataatt gctataaata
    15301 ttagtcctat ttctccaaag tattttttca ataaagcccc ctccttttta tttttttgca
    15361 aaattataaa ccccctaaac agcaagagag tttttctata agcattacta taaattaata
    15421 tagtaaattt tttcagtatt ttaaatctaa atttacatac attttgagct caaatttata
    15481 tccactattt aacagtaata tattaatcat tttttgtaaa caccttttta ataaattttt
    15541 atatttttta tattttttta cctatactaa atttttttat agatattttt aatatatatg
    15601 atactttaat attatgcaaa taatgtcata taagttacac tttagttatc ttagttacaa
    15661 ctttgtcggt ttactttttc tactttcttc gatataatta taatatattt ttgatacaat
    15721 tcgacaaaag ggggaatgct gtaattatgg taaaaaaaag aaaaaagaaa actgttacac
    15781 ttactatact tgttgtaata gttattggta ttttttctat ggcatgggcg gacatgtcta
    15841 gaaaaaaaga aatgaaagaa actcaagaaa gacttaaagc tgaaagatta gaaaaagaaa
    15901 gaattgaaaa agaaaaaaat gaacctatta ttggtgcaaa aaaagaagct gtaaaagaat
    15961 atggatatga cgcaaaaata gtttgggaca aacttaacaa atacgactat tcaaacaatg
    16021 gagaaaagat agtctttctt acatttgatg atggaccatc tactactaat actccacaag
    16081 ttctagatat cttgaaaaga catggtgtta gaggaacttt ctttattaag ggtgattctc
    16141 ttgaaagaaa aggagctaat gaaattttaa aaagaacatt tgacgaagga aatgcaatag
    16201 cccatcactc ttatactcat gactataaaa aactatatcc taacagaagc ctaaatctcg
    16261 atacattcgt aaatgaactt aacaaaactg atgaagctat gaaaaaagtc ttaggaaaga
    16321 atttttcctc aaatgtagtt agatgcccag gcgggtatat gtcatggaaa aatatggaac
    16381 ctctaggaaa ctacttaaaa gagaaaaaca tggcatcaat tgattggaac gctttaaatg
    16441 ctgatgcaga aggtaaaaag aaaaatgcac aagaattatt tgaacatgca aagaaatctt
    16501 ctgaaggcaa agaaatggtt gttcttttaa tgcatgatac ttatggaaaa caagaaacag
    16561 taaatgcatt ggaccaaatt ataacatatt ttaaagacaa tggttatcaa tttaaaattt
    16621 taatataata aaaaagcaag tttattgaat gtacatttta tactcaatag acttgctttt
    16681 actttactct attttactag ctcgattttt acaaattttt tctttcctat ttgaacaact
    16741 aattcactct cttttacaat agtgcttaaa tcctctactt tttcaccatt tacctttact
    16801 ccaccttgag aagctaatct tctaacttca ctcttactct taacaatctc attagaaact
    16861 agtacttcga ttaagtcaaa tccatcttcc ttaacttgaa ttgtttgtat atcttcaggt
    16921 atttgacctt tttggaatac agatttaaat ctttcttcag cttctttagc agattcttct
    16981 ccatggtata atgttactat ttctcttgct aagttcatct ttatatctct tggatttact
    17041 gaaccctctt tcaactgtga ttctatttta ttaacttcat caggatgaac atctgtcact
    17101 aaattgtagt atttaattat aagttcatca ggaatttcca tagatttttg gtacattatt
    17161 cccgcttctt catctattcc aatatagtta cctaaactct tactcatttt ttctttacca
    17221 tctaatcctt ctattaaagg catcattatt actatttgag actccatacc aaattctctt
    17281 tgtaatgatc ttcccattag taaattgaat ctttggtcag ttccaccaag ttctatatca
    17341 gcttctaatg ctatagagtc atatgcttgc attaatgggt agaagaactc atgtactgat
    17401 attggcattt gtccttcata tctcttttta aaatcttctc tttctaacat tctcgcaaca
    17461 gtaatagttg ctgctaattt tattacatct tcaaaattta acttagctaa ccactcgcta
    17521 ttaaatctta caatagtttt ttctttatct aaaactttga aaatttgttc ttcataagtt
    17581 tttgcatttg caagaacttg ctctgttgtt aaagcttttc tagctttaga ttttccagtt
    17641 gggtctccaa tttttcctgt aaaatctcca attattatta ctatttgatg acctaaatct
    17701 tgtaattgtt tcatctttct aagaactact gtatgcccta aatgtatatc tggagcactt
    17761 gggtctagac ccaattttac tatcataggc tttccttctt tttctgattt aataagcttt
    17821 tcccttaact ctttctcatc tattaaatca tctacacctt tcataattat tcgcatttgc
    17881 tcgtctatcg atttcatttt tcattcctcc taaaatattt atataatcta taatttttat
    17941 ttttataata aaaaaagctt tcatcctctt aaaaggacga aagcattgct tacgtgttac
    18001 caccttagtt catcaatatc tcacgatatt aatctcttag agtacaatta catatactcg
    18061 tgtactataa cgtgtactaa tccgatatct cttaatggtt gttatctttc agagatagtg
    18121 ctctgagatg tattcaaact aaatcaattt attccatttc accaaactgg aactctctgt
    18181 taaataaaat ctagccctac ttcttctctt catagcattt atatattcag attatttcat
    18241 caattacaag aaatttttct taacttactc ataatatatt attattttta tattttgtca
    18301 acctttttta ttattatata catgtttttt tacattatac tactttttta tattttttac
    18361 caatacccaa aatttatttt tcaatcaaaa gatttatttg tttattgact atattactct
    18421 gactcaatct tatatttatt ttcttattta aaaatgcgtt tataattatt aaaccaataa
    18481 ctgttacatc aaatataaaa aacagcaata aaattattat caaaaataaa attctagcat
    18541 ataataattt tctaaactta gctattataa agttttgtag tgacatacat gagtctctaa
    18601 tgataaaata gagacttata taggttattg atataaagat tgtttttaaa taaacagaat
    18661 caactttaac attcaacagt tttagaactt caaaaatggc tagataagaa acacatatgt
    18721 aaaaagcttt ttttgagcaa cataaaaatt ggtttaaact tctaaaattc ttaaatatta
    18781 aaaatttttt tagagaatta gaatctaaaa tatgcaattt attccctaaa attaaactta
    18841 ataaatatat gcaaaacacc ataccaaaag gaaacaatgc tatcattaaa taataaataa
    18901 aatttgtata cccattaaaa taaatccatt tgctatatcc ttgaaattct ttcataaaac
    18961 tataacctat taatgttgaa gcatatatat caataaaaac cattacaata agcccaaata
    19021 ctgaaccata tactaaatca tccataacca ttgtaggctt atttattaga tagccacaca
    19081 ttataccaag taatacactc tgacttgccc aaatagcagt tcctagattt ccaagtacca
    19141 gagaaattat taaaagcgaa gtaattccag ataaaatggt atactttaaa tcacatttca
    19201 agcagattat acaaaaaaat actggcacta taaaatctaa gtaaatagca tatccaaatc
    19261 cagtactcac agctataatt gttactacta tgaataaaga tgacaataaa gctgcttcag
    19321 ttaatttttt agtagtattc aaaacactgc ctccataaat cataaatttt ctaactaaag
    19381 ttttgttttt aatatagtat atcacttttt aaaaatattt ttaataaata taaattttaa
    19441 taaaggtatt tatgttaaaa atggtataat gtatcttaat attcagtttt ttaagatgct
    19501 aggaggtaat tactatgttt aaaattaaac actttaatga tttgagttta gatgaatttt
    19561 atgaaatagc aaaatcaaga tatgaggtat ttgcttgtga acagaagata ttttcattaa
    19621 acgattatga tgatatagat aaaaactctt atcacatatt tttaaaagaa aatggattga
    19681 tttgtgctta cgctagaata attcctaaag aatacagctc ttataatgat gtttccattg
    19741 gtagagtttt agttctttct agtcatagaa gaaaaggatt agcaaaacaa atgatggatt
    19801 gtgctataga ttttataaaa gttaacttac acgaaaataa tataacctta tcagcacaaa
    19861 cttatataaa gaacctttac ttatcttgtg gttttaaaga aatctcagaa gtatacgacg
    19921 aagcaggtat tgaacatatt aaaatgagat tatagtgttg acaagctaat attgttaata
    19981 tataatttaa gtataaatta aatattgaat tgatatttag gtatttgaaa ataccttaca
    20041 tagagtcaga aggcttttgc tttctgactt ttttattatc aaaattcaat aattatatgg
    20101 attcaaagtg ttaattttta ttctatattc tactttcccc aaaagtaaga attataccca
    20161 actttgtatg ataggcatct tgcctatctt ttttttgtaa aagtaacaag gtaataatat
    20221 aatgcatagt ttaaaataag aagattagcc caggctaaat ttcaagcatg gaggtgctat
    20281 tatgaaaaac cttaacgata ttcaagtgaa aaaaactgtc aaagttgaag atatattatc
    20341 tagtggtaat ttaagagaaa gaatgttagc gcttggtctt actagaggag ctgttataga
    20401 tgtagttaga aaaggtccaa aaaataattt aactgtctat aaaatcagag gtagcaagat
    20461 agctctacga caagaagaaa gtagcttaat attagtttct gacatttaaa aatttctagc
    20521 aggaggatat taatatgggg ttgacacata actcaactaa aatgagttct ttaaaagaca
    20581 tgtttgatat agacaataag gaagaccagt ttgtaattgc attggctggc aatccaaata
    20641 caggtaaaag tactgtattt aatcatctta caggacttag acagcatact ggaaactggc
    20701 caggaaaaac tgtagctaca gctcgtggta attttaaata taaaaatacc gaatatgcat
    20761 taatagattt accaggaaca tattctttat ttgccttatc acaagaagaa attgtagctc
    20821 gtgattttat atgttttggt aatccagatg cagtaatagt agtatgtgat gctacatgtc
    20881 ttgaaagaaa tttaaattta gtatttcaag tgatggaact tacagataaa gttattttgt
    20941 gtattaattt aatagatgaa gctagaaaaa aaggcattac tattgataaa aaacttttag
    21001 aggattctct tggtattcca gttattttaa ctgctgcaag aaatggctct ggtatggatg
    21061 aactattgga tactttaaat gatgtatctt ttgacaaata taaattaaat aataaacctg
    21121 ttagatacaa tgaaaatata gagaatgtgg taaaatcaat tcaaccagaa ttggataata
    21181 ttataccagg tataaattct agatggttgg gacttagact tattgatggc gatgaaagta
    21241 tatttgaatc tatgagtaat tatatagaca aaaattctat agatgctatt aatgaagtaa
    21301 agaaaaagat tccagacaat ataaataaac agaaaataag agatgagttt actaaaatca
    21361 actatgatta tgctaaaaaa ctgagtgatg agtgttgttc taatgttgct aaaaaatcaa
    21421 ctgatagaga agaaaaagta gataaaatat taacatctaa aatatttggg cttccaataa
    21481 tgctcttatt attaggtact atattgtgga ttactataga aggagctaac tatccatcca
    21541 ctttattatc taatttatta ctcggatttg agccaagtat ttcgggtata ttaaatagta
    21601 ttaattgtcc atcatggtta aatgatatgt tggttttagg attatacaga acattagcat
    21661 gggtaatctc tgtaatgcta cctcctatgg caatattttt tccattattt accctacttg
    21721 aggattttgg atatttgcca agagttgcat ttaacttaga ccacctattt aaaaaagctt
    21781 gtgcacatgg aaaacagtgt ttgactatgt gtatgggatt tggatgtaat gcagctggag
    21841 ttattggttg taggataatt gactctccaa gggaaagact tatagctata cttacaaaca
    21901 actttgttcc ttgtaatggt cgttttccta ctttgatagc tatatctaca atatttttta
    21961 gctcagttat aaccaactct ttcgtatcaa gcgtagcaac tgcactttgc ataactttac
    22021 tgataattct aggtgttata ataacattgt tggtttctta cactctttct aagacgctat
    22081 taaaaggagt tccgtctaca tttacattag aacttcctcc ttatagagtt cctcaaatag
    22141 gaagaacttt atatacctct ataatagata gaacaatatt tgttttagga agggctgtaa
    22201 tggtagccat acctgctggt gtcataactt ggatatttgc aaatatatat ataggagatt
    22261 taagtatatt atcacatgtt gcaaactttt tagacccttt agctaaatta attggtcttg
    22321 atggttttat attacttgct tttattcttg gattcccagc aaatgagata gttgtaccta
    22381 tacttttaat ggcttaccta gcaactggtt ctatgataga attagatagc tttagtgctt
    22441 taggtcaagt tcttagagaa catggatgga cttatttgac agctttaaat gttatgctgt
    22501 tcagtttact gcattggcct tgtgcaacaa cacttttaac aataaaaaaa gaaactggta
    22561 gtttaaaatg gactgcctta ggattcttaa tgcctactat acttgctttt gttgtttgtt
    22621 ttttaacaac tacagtttac aatttattta tataattagt attaactgac agtagacata
    22681 tattagagaa accatttaaa aatttatata ctttattata aagcatagag atatattcaa
    22741 tgataagtaa aattacttaa catttgaata tatctctatt ttaattctta tctggatact
    22801 tggattgaaa tttcagtcat ataattatct tcattacttt cacaaaaaaa gtcaagtata
    22861 ctctcctcat acgaatttcc aacaatttta tattcatttt catatatata ttttttcaat
    22921 ttttcgtaag atttatatga atcctcatat tttccaatat gttttatgca agcatacatt
    22981 ccttctggct ttacatatag ctttttatcc tttatttttt tatctatctt caaataaaaa
    23041 cttgatatac ttaaatagtc cccatttttt atattttcat tacttactat tactcccaac
    23101 tcatatcctt gatacaaatt tttcgattta caataattgg taaaatctat taattccatc
    23161 ataaaatcac tattactcat attactcaaa tcgcttgata gaactaaata ttcttcaaac
    23221 tttttggata tataaatttc ttcactattc attttagaaa ttccttcaac tgttatattt
    23281 attctatttt gcatcttaga acttatcttt cttagttttt ttattttttc tcttatcttt
    23341 ttttcttctt ctttaagcat tttcacacaa agctggggag ttctattttg tatatactct
    23401 tttatttcct ctaaactcat tcctatttct cttaatgatt gtaatatatc aagtgtatca
    23461 tattgataaa ctgagtaata tctataatta tttttatctt tatattcagg agaaaaaata
    23521 cctattttgt catagaaaat taatgtctgc ttagatatac cacacaattt agcaaattca
    23581 cctgttgtaa aatactgttt ttccaagggt tatacactcc ttttcttttt gttgtctata
    23641 tagttactat attctttatt atttactaaa tcaagtagtt attattttag aaaatcaata
    23701 tggttttgat tttaaagctt aaatatcagt tagatgtcag ttataaatat tttacccttt
    23761 cccatcataa aaaagatatc ccctcttaac ttttggatgg aatattatat ttatacttgt
    23821 tagagtgaaa attgtaatag gtgctacaat aagatattta attaaacata aagttaatta
    23881 ttgtaataaa aaatctttag ataaattaga gttaaagtac ggaaatatag atagagaaaa
    23941 agctgttaaa ctagaaatat tttatcagta tttaatagaa cttgaatata tagaaatgag
    24001 tttattaata agaagattag atactgcaat aacatcatta gcattagtat ctattataac
    24061 aatagcatca tattatttaa tcagaaaaaa tgtgtaatta tgtaagctat ttataataaa
    24121 acactgataa aattaataat aaaaaggtaa taggatttct atactacctt tttgttttta
    24181 taatatagtg taattttatt atatttttgt atgctaatgt aactagataa tcataagata
    24241 acacattaaa agaaaattat gaaaacttac attctgtata gttaatataa aacataagta
    24301 atataaattt atgtaaagca acaaaagata gatttacatt ccatatagtt aatataaaac
    24361 cttagagaaa gcgaaaacgt accattaaaa tcaaatattt acattccata tagttaatat
    24421 aaaacgttgt aatcatagtt ccaattagcc actttaacat gcatttacat tccatatagt
    24481 taatataaaa caccaaaata aacttagtat tttcaacact tacacgtata caactctcct
    24541 aaatttgcag tgaacgagca atagtgcaat tgataacgct tatcatgcac tctcaacgcc
    24601 ttatatttca actgttacgc caaatttttt cacaaatatc gctcactgca aaattcctat
    24661 aattttatta tatcataaat atattacttt tgaatattga taccaattta taccataata
    24721 aaagcaaaaa aacgtaatct atctacatta gatttaaatt ctataactta aagtttttta
    24781 cataatattt atgcttgttt aatcaatcta atatatcatt cttgtatatt gcttttaata
    24841 gtcttttttc ttaaataaat atctatctga acaagcatag tttaattaaa aacttttgta
    24901 ttcccttaaa actgtatcta cctcttatta ttttatttat gatatattat ttttaatcta
    24961 aaaatagata tctattttta ttatggttat ccctttttaa aatactttaa tcatatacta
    25021 ttcccaattt aacatccatt gaaatgctat tttcttatat tgcaatttat aattgatata
    25081 tcttcaatat aataatttaa tgtatttttg attttaaagc ttttcagtga tattattgat
    25141 aaattagaat taattatcta gctttaaaag gtcaaagatt tctgttgctg tctgcggttt
    25201 tccaaataaa tatccttgta tgtaatctgg ctttatttgt ttaactaaat catactcttc
    25261 ttgtgtttct acaccttcta aacatacttt tattcctaca tcatgacaaa ttgcaacaat
    25321 aaaatgtata aatgtagcat caaacttact ctttaatata tctttaacaa atactctatc
    25381 aattttcact atatctattg gagaaaattt taaaacttct agagacgagt atccagtacc
    25441 aaaatcatcc atagcaatat aaattcctaa atcttgtaaa gccttaaatt taaactgtaa
    25501 aatactcata ttttgtactg tatgactttc tgtcaattct aaaacaagat tttgataagg
    25561 aaaattttca tcatctataa tttttactat atcttcaata aatgtgtctt ctaatatttg
    25621 aacagctgaa acgtttacac tcactttaaa aaaaggatag taatcaatcc atttcctaaa
    25681 agtacgtaat gccattcgaa gcacccaagc ccctacaata tttatcatat cattttcttc
    25741 taatattgga ataaattcca aaggagaaat tgctttgcat ttgtcattag tccaccttaa
    25801 aagaacttct acacctatta ttttatgact ttctgtatct acttgtggct ggaatcgaag
    25861 actaaacccc ctaaaatcat cattaattga tgcctttaaa tcccgcatca tttctaatga
    25921 atacatttta ttttttaata tttcttggga gaaaaaaaca agcctgtttt taccatgctc
    25981 tttcgcatat tgtaaagagt aactagcaca cttataaagt tcttttactg tatctccatg
    26041 ttttggatat attacacaac cagcagaaat tgttatattt aatccatatt ttctccatag
    26101 ttgaaggtgt ataatcatat tctgtatttg attatataga gttagaattt cattttcttc
    26161 aacattatca acaagaatgc ccatttcgtc cccatcaagt ttataaagtt cagcattatc
    26221 tggtaaaata gattgtacag actgtgctag tgtttttatt atattatctc caaaatccct
    26281 atcatacatc tcattaacat ttttaaaatc gtcaatatct aataatacta tgcataattt
    26341 ttcaatcata ggatttgaaa ttttatcttc aaatacactc ataaattcat gataattcag
    26401 taactgtgtc aatgaatcaa tcttattttg tttacctaat tgcgtcatta ttcctgcaaa
    26461 aatacttggc tctccaaatt catcacgcat tagttgacct ctacatctta accatatata
    26521 ttctccacta cgatttttag ccctaaattc cactgtatga taatccatct ggtttttacc
    26581 tatttcagtg tttgacttat aaaaacgatt ccagtcttct ggatgtacaa tttttttcca
    26641 gtaaacaagc ggatttttaa caatttctcc tggtaagtca aataattcaa cttgtgatgg
    26701 tgaatatcga aatacgcctg ttttcatatt gcaaatgtat atatattcat ctgtacctct
    26761 aatcaaagca tcgtaaagca atgtagaatt ataatcaaaa ttgtctcttg aaaaattaaa
    26821 aactcctttt tcttctttat tatttgatat ttcatgaaat tcattaatct taattggttt
    26881 atttaagctt gttgagtttg caatatctat tgattgatgc atatgaacaa ctgtgccatc
    26941 ttgccatgta attaaactat cataattttc aaaaacacga tttaacttat tacatttttc
    27001 ataccacttt attaatactc cttttttatc attctttaat aattctaaaa ctttacaaaa
    27061 actacaagta gaattttttt caggatataa tacttgccaa caaacttttc cttctggatc
    27121 taaaatatta tattcttctt tcattttttt gttcataaaa ataatttcat tagtatgaat
    27181 atttgtaaca tatatattaa tctgtagttg atttaatata acttcaaaat tatgtttgtt
    27241 catatactta tctcctccat agttactgct ctttataaca acattgttaa aattattctt
    27301 tttagaagat ttacttataa cttatacata tacactaaat accttaattt aattagaaag
    27361 tttattactt catattttaa attataattg ataaaaaaaa atacagcaat atagtattac
    27421 caatttaaaa aaaattaata ttacataata catctctc
//
LOCUS       DAEHWM010000046        27326 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.047, whole genome shotgun sequence.
ACCESSION   DAEHWM010000046 DAEHWM010000000
VERSION     DAEHWM010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 27326)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27326)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27326
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.047"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1588
                     /locus_tag="KNP36_002058"
     CDS             <1..1588
                     /locus_tag="KNP36_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="M3 family oligoendopeptidase"
                     /protein_id="HBF0873931.1"
                     /translation="QKNIHKINLLRNKIETLSNIASIRYSTDTFNKFYKEEKNYWDEY
                     MPLYEELNSYFYNAIVNSKFKYDLIKEFGEQFFTIVEYSLKSFSKEIISELQEENKLC
                     SEYTRLLASAEIMFDGKIRNLSGMGKFMYSKNRKTRELANKAYYNFFEENETKFDDIF
                     DKLVKLRDKMSKKLGFEDFVELGYIRMMRSDYREYMIKNVRKQVLKYVVPMANELYEK
                     QAKRIGLEYLSYIDEGVEFLTGNASLKGDSRYIIKNGKRMYSELSKETNEFFDFMLEN
                     ELMDLETKKGKGAGGYCTYIPDYKSPFIFSNFNQTADDIDVLTHEAGHAFQLYMSRWI
                     DMPEINFPTLDSCEIHSMSMEFITWPWMDLFFKEDTDKYKFTHLSSSIKFIPYGVIVD
                     EFQHYIYKNPNVDKSKRKEIWRFLEKKYLPHRKYGDNSFLERGCWWFKQGHIFKNPFY
                     YIDYVLAQICALQFWKKMIQDRDAGWKDYINICKVGGTKSFLDIVSMGNLYSPFDDGC
                     IESIIGDVKSWFDEINDSKL"
     regulatory      1920..2030
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            2134..2505
                     /locus_tag="KNP36_002059"
     CDS             2134..2505
                     /locus_tag="KNP36_002059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrdX family protein"
                     /protein_id="HBF0873932.1"
                     /translation="MIIITNNPKVKEEVQGREVLFKDTTYIGILEASRDLIHEGYELL
                     SHPLYGSVKPNETPYRTVILKKGNRLDINSLTLIEEAIITASKFQNNKKTPKWTESVQ
                     DDFRVIDYDIFYNTIQRMQYE"
     gene            2600..3547
                     /gene="trxB"
                     /locus_tag="KNP36_002060"
     CDS             2600..3547
                     /gene="trxB"
                     /locus_tag="KNP36_002060"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HBF0873933.1"
                     /translation="MENVYDLVIIGSGPAGLAAGLYGARAKLKTLILEKDKTGGQIVI
                     THEIANYPGSVPNATGPSLIARMVEQCKEFGAEMLRDNIVDTELDGDIKVLKGEKAEY
                     RAKAVIIGTGATPRKIGCPGEKELTGKGVSYCATCDADFFEDFEVFVVGGGDSALEEA
                     MYLTKFARKVTIVHRRQGFRCAKSVEEKAKANPKIEFLLDTVIEEIKGDGILESVVFK
                     NKVTGETHEYFADEEDGTMGVFVFVGLDAQTDLFKGKVDMDEKGYIITDEDMRTNIPG
                     VFAAGDCRSKTLRQVVTATNDGAIASIVAEKYIDEKFGN"
     gene            3651..3968
                     /locus_tag="KNP36_002061"
     CDS             3651..3968
                     /locus_tag="KNP36_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol reductase thioredoxin"
                     /protein_id="HBF0873934.1"
                     /translation="MLDLDKATFEEEVLNAEGFVFVDFWSEGCEPCKALMPDVHKLAE
                     TYGDKIKFCKMDTTKARRLAIKQKVLGLPTMAIYKDGEKVDEVTKDDATVPNIENMIK
                     KYL"
     gene            4237..5523
                     /locus_tag="KNP36_002062"
     CDS             4237..5523
                     /locus_tag="KNP36_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006439082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase component B
                     subunit"
                     /protein_id="HBF0873935.1"
                     /translation="MRLELGKIFIKDIQFGDVTEVKDGVLFINKQEMLQEIGGDEHIK
                     SIDIELARPGESVRITPVKDVIEPRVKVEGNGGIFPGIMSKVDTVGEGKTHALKGVAV
                     VTTGKIVGFQEGIIDMTGEGAKYTPFSKLNNVVVIAEPIDGLKQYAHEKAVRMIGFKA
                     AMYLGEVARNLTPDEVSVYETKPLLESIKEYPELPKVGYVYMLQTQGLLHDTYVYGVD
                     AKQIVPTLLYPTELMDGAIVSGNCVSACDKNPSYVHINNGVVEDLYARHGKDINFVGV
                     IITNENVYLADKERSSNWTSKLCKYLGLDAVIVSQEGFGNPDTDLIMNCKKIEMQGVK
                     TVIVTDEYAGRDGGSQSLADADVRADAVVTGGNANQVVVLPKLDKVIGHLEVVDVIAG
                     GSDGSLRADGTIEVEIQAITGATNETGFGHLTAKGY"
     gene            5635..6108
                     /locus_tag="KNP36_002063"
     CDS             5635..6108
                     /locus_tag="KNP36_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:5767..5769,aa:Sec)
                     /transl_table=11
                     /product="glycine/sarcosine/betaine reductase complex
                     selenoprotein A"
                     /protein_id="HBF0873936.1"
                     /translation="MSLLSNKKVLIIGDRDGIPGPAIEECVKTVEGAEVVFSSTECFV
                     UTAAGAMDLENQNRVKDAADKFGAENVVILLGAAEAEAAGLAAETVTAGDPTFAGPLA
                     GVALGLSVYHVVEEPIKSLFDESVYEDQISMMEMVLEVEEIEEEMSGIREEFCKF"
     gene            6140..7450
                     /gene="grdB"
                     /locus_tag="KNP36_002064"
     CDS             6140..7450
                     /gene="grdB"
                     /locus_tag="KNP36_002064"
                     /EC_number="1.21.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_except=(pos:7187..7189,aa:Sec)
                     /transl_table=11
                     /product="glycine reductase complex selenoprotein B"
                     /protein_id="HBF0873937.1"
                     /translation="MGKLKAVHYINQFFAGIGGEEKADTKPHVAETLPPISLQLDKLL
                     GEDIEIVGTVVCGDSYFNENIDSASEEVLSMVKGFEPQLFIAGPAFNAGRYGVAAGTI
                     TKVVKDALNIPALTGMYVENPGADMFKKDVYVVETSDSAAGMRKALPKIAKLAVKLAN
                     GEEIGTPKDEGYIARGIRVNYFHEDRGSKRAVDMLVKKIKGEPFETEYPMPNFDRVDP
                     SKAVKDLSKCKIALVTSGGIVPKGNPDRIESSSASKYGTYSIAGVMDLTEETYETAHG
                     GYDPVYANLDADRVLPVDVLRDLEKEGVIGKLHETFYTTVGNGTSVANSKKYASEIGA
                     ALVADGVDAVILTSTUGTCTRCGATMVKEIEKTGLPVVHMCTVVPISLTVGANRIVPT
                     IAIPHPLGNPALDPTEEKALRRGLVEKALNALTTEVDGQTVFEK"
     gene            7706..9238
                     /locus_tag="KNP36_002065"
     CDS             7706..9238
                     /locus_tag="KNP36_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014520415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III family protein"
                     /protein_id="HBF0873938.1"
                     /translation="MTYPVLKGAGYVLIHTPDMIVQNGSTCTVERATNPDSEFLKEVS
                     NHIRSYEDVVNYMPNQVYIGNRRPEELRDLPMPWCEQKIEGTRNGKFGEIMPQDEFIA
                     LMQISDAFDLVKLSQEFIDEVKPKIENNYPEIAPFVGKLKGDDIEEGKELVATHIAEG
                     LYHDGKFVGYVKRAHDVDVNLNAHTMFENLVVKASGVLSAIQMLRHSKIDPAEIDYVI
                     ECSEEACGDINQRGGGNFAKSIAEIAGLQNATGSDTRGFCAAPTHALIQAAALVKAGI
                     HKNVMVVAGGASAKLGMNAKDHVKKGLPVLEDVVGGFAVLVSENDGVNPVIRTDLTGK
                     HTVGTGSSPQAVMTALITSGLDRANLKITDVDVYSVEMQNPDITKPAGAGDVPEANYK
                     MIGALAVKRGDLEKKELKDFVSNKGLPGWAPTQGHIPSGAPYIGFLIDDLTTGNRNRA
                     MIVGKGSLFLGRMTNLFDGVSFIAERNTGVTEETSGISKDEIKKIIAESMKKLALDML
                     EE"
     gene            9249..10394
                     /locus_tag="KNP36_002066"
     CDS             9249..10394
                     /locus_tag="KNP36_002066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine reductase"
                     /protein_id="HBF0873939.1"
                     /translation="MSKKVIADVFLEVANAIESGEFGKKVKIGVTTLGSEHGVENMVN
                     GAQLAKSNLFDIVLIGPKVETDLEVVEVNDEKEMHAKMEELLDSGYIDACVTMHYNFP
                     IGVSTVGRVITPAKGKEMILATTTGTSATNRIEAMVRNAIYGIATAKSMGNKCPKVGI
                     LNVDGARQVEKCLKELKDNGYDMEFADSIRADGGCVMRGNDLLVGAPDVMVTDTLSGN
                     IFMKVFSSYTTGGDYEAQGFGYGPGVGEDYDRKVLIVSRASGSPVVANALKYAYDVVK
                     GDISNVARNEFAKVKKAKFDDIISSLTKKEVKAEKVEVKMPDKEIVTRQIAGVDIMDL
                     EDAVSELWKNGIYAESGMGCTGPIVLVNEAKGDLAVETLVKAGYTAK"
     gene            10704..11783
                     /locus_tag="KNP36_002067"
     CDS             10704..11783
                     /locus_tag="KNP36_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0873940.1"
                     /translation="MSRVKNVVELLETKGVDALYLTKKTNVNYISGFPDEEAYAVICK
                     DGNFLVTDSRYMELAEKVCKDFEIINWHNFDRSVAKAVKSVCDKVGIKKLGFERTNIV
                     FDKYEELKNLIEKDNGELIPTENIVETLRYVKDKDEIKNTRKACEIADKALEELIPHI
                     KAGVSEIELATKLEYFMKMNGAQNIGFETILISGAKTSLLHGKPSDKIIEKGDFVLID
                     YGAMYNGYISDTTRTFIVGGASEKQLEIYNLVKEAQNVGVENMKAGVHATIPDAEIRK
                     VVKKYEDYYYQGIGHGVGRDVHEEPFIGNYGDKIIEEGCIITMEPGIYFPGWGGVRIE
                     DTVLITKNGPERLTKFPKDLMILDK"
     gene            11896..12495
                     /locus_tag="KNP36_002068"
     CDS             11896..12495
                     /locus_tag="KNP36_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873941.1"
                     /translation="MYKKHKFIKNIKKAWYKIKLIDRCLIIVMAILMFQSIYNLFVNE
                     VNSQDTTTIDVVVRTTSAAIFGYFLSANFIKRPLRKYTNTDVSSNLFIDNNLSPKGQE
                     SNQNNIMNVKNTIGFTSEADNYEKKIPINNNEGFEEGETSELQIIIATVICIVALTVL
                     FVVRNFTTTTSASLGTISQMRDFVSGCVGFLLGCPSKPD"
     gene            complement(12681..13553)
                     /locus_tag="KNP36_002069"
     CDS             complement(12681..13553)
                     /locus_tag="KNP36_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0873942.1"
                     /translation="MNINYLYYFQTVCKYKNMTKAAESIHISQPSITLAIKELEKELG
                     FELFYRIGNKIELTPEGKIFLDKSKHFIKQFEDFQCDALDLGKKRKASLKIGIPTVLG
                     TFLLSKILPRFNVIYPDIELKIFEVPTFVGAKMIEESTLDFCIGIIDSDIYDDIDSKT
                     IYKTELYLVTNPKNELAKHPIISNYMLKNVPFVILSEGSYHYKIITKRLEKAKPNIIL
                     HSNQLSTIRYLLENDLASTILYKEIFQNTENLCSIPLERAITANIGVLWRRNQYISHS
                     MKLFIEYMASIHIN"
     gene            13970..15373
                     /locus_tag="KNP36_002070"
     CDS             13970..15373
                     /locus_tag="KNP36_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873943.1"
                     /translation="MKGSDLVKFELMDFLMNPFVLMFAAVITGILFGKIKFGKFNFGV
                     SGALFTGLFIGWLAYSLGNLIIAKGETAAGYKAATVMMGNGIISSDFFDFFLIIFVAA
                     VGLLAAKDMKAVLKKYGARFVILGVLITFIGGSMTYAMTLLSSDKGSSAYEVSGVYTG
                     ALTSSPGLAAALETAGKHAEDVSKEFEKASIKDKKEILKVVDPEGKLDVNTTTSLTQE
                     QIDKYIAYAEAGVGIGHAVAYPFGVLIVILGVNFLPKLFRMDLKEERRKYEKEMKEAR
                     DSVSGKTIPEVPFNIITFFLTCLAGYLVGGIHVFMGPLGYFTLGATGGSLIVSLVLGY
                     IGKIGVVNFRMEEKVLNILKQIGLVFFLAIVGLRYGGKVVDSIMTSGMHLALVAIAVG
                     VTAMMIGFLVGKYVFKLNWILLSGAVCGGMTSTPGLGAAVDALDSDDPAAGYGATYPF
                     ALLTKVILVIVLHKLPM"
     gene            15400..16944
                     /locus_tag="KNP36_002071"
     CDS             15400..16944
                     /locus_tag="KNP36_002071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase/transferase family protein"
                     /protein_id="HBF0873944.1"
                     /translation="MNNEGAFEELSGRLRNKELCDLIMNADEAAKIIEDGMVIGVSGF
                     TPSGYPKAVPLAVSERAKSGEKIKLTVYSGASLGPEVDGAWSEAGIIERRLPYQTNSI
                     LRNNINKGVVDYIDMHLSHSTQFLNYGTIPKVDVAIVEALAITEEGNIIPTSGIGNSP
                     SFIKSADKVIVEINLAKPMEMEGMADIYITENPPNRKPIEINHPKDRIGTTYIPCGLD
                     KIAGVVITNMQDKTRPLGVVDEASKKISNNIIAFLREEVKAGRLSKNLLPLQSGVGSV
                     ANAVLYGLCESEFENLTCYTEVVQDSMLDLIRMGKVTMASTTSVSPSPEGLIKFEKDI
                     DFFKDKIILRPQEISNNPEIARRIGVIAMNTAIEVDIYGNVNSTHIMGSKMMNGIGGS
                     GDFARNGAITIFSTESIAKNGDISSIVPMVSHVDHTEHDVMVIVTEQGYADLRGLAPR
                     ERAIKIIENCAHPDYKEQLRDYLNRACKSGAKQTPHILDEALSWHSKFMSTGTMKKAE
                     TFKSAL"
     gene            16975..18366
                     /locus_tag="KNP36_002072"
     CDS             16975..18366
                     /locus_tag="KNP36_002072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="HBF0873945.1"
                     /translation="MEKAVENFEDLSKEYINGYIERARKAQREFECYTQEQVDKIVKI
                     VGKVVYYNAEYLAKLAVEETGMGVYEDKVAKNKSKAKVIYNNLKDKKSVGIIDIDRET
                     GITKVAKPVGVVAAITPCTNPIVTPMSNAMFALKGRNAIIITPHHKAIGCSTKTVEMI
                     NEELEKIGAPENLIQILDQQSRENTRNLISSADVVIATGGMGMVKAAYSSGKPALGVG
                     AGNVQCIIDRDVDIKEAVPKIIAGRIFDNGIICSGEQSVIVAEEMFDKIMDEFKNNKG
                     FIVRDKVQKEAFRNAMFVNKSMNKDAVGQSVHTIAKIAGVEIPEDTKIIVIEADGPGE
                     EDIIAKEKMCPVISAYKYKSFEEGVAIAKANLNVEGKGHSVSIHSNTVKNIEYAGENI
                     EVSRFVINQCCATSAGGSFFNGLAPTNTLGCGSWGNNSISENLDYKHLINISRIAYYM
                     PENEVPTDEELWG"
     gene            18559..20055
                     /gene="abfD"
                     /locus_tag="KNP36_002073"
     CDS             18559..20055
                     /gene="abfD"
                     /locus_tag="KNP36_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybutyryl-CoA
                     dehydratase/vinylacetyl-CoA-Delta-isomerase"
                     /protein_id="HBF0873946.1"
                     /translation="MALMTGAQYIESLRKLNTKVYMFGEEVKNWVDHPMIRPSINCVA
                     ATYDLAHDPEYADLMTVTSNITGEKINRFGHLHQSVDDLIKKVKMQRLCGQKTASCFQ
                     RCVGMDAFNAVYSTTFECDKAHGTNYHDNFVKYLTYIQENDLVVDGAMTDPKGDRSLS
                     PSAQPDPDMFLHIVERREDGIIVRGAKAHQTGSINSHEHLIMPTISMTEADKDYAVSF
                     AVPSDAEGVFMIYGRQSCDTRKLEEGADVDLGNKEFGGQEALVVFDNVFVPNDRIFLC
                     GEWDFSGMLVERFAGYHRQSYGGCKVGVGDVIIGAAALAADYNGANKASHIKDKLIEM
                     THLNESLYCCGIACSSEGHKTEAGNYQIDLLLANVCKQNVTRFPYEIVRLAEDIAGGL
                     MVTMPSEKDFKSDLKVGTSGMTIGEVCNKYFKASSVASTEERMRILRFLENICLGSSA
                     VGYRTESMHGAGSPQAQRIMISRQGNINQKKELAKKIAGIKKEEALNL"
     gene            20190..20465
                     /locus_tag="KNP36_002074"
     CDS             20190..20465
                     /locus_tag="KNP36_002074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873947.1"
                     /translation="MTCGVRFCGGCNPRYERGKALTIIKEHFNGRVDFSIAQENVEYD
                     LLLIIGGCATLCASYQQYKVKNECVKMWDFSHIERVINVIESAICET"
     gene            20489..21796
                     /locus_tag="KNP36_002075"
     CDS             20489..21796
                     /locus_tag="KNP36_002075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA hydrolase/transferase family protein"
                     /protein_id="HBF0873948.1"
                     /translation="MSWQELYQSKLCSATEAVKQIKNGDTVVFAHCVGEPPALVEAMI
                     ENAEQYKDVEIKHMVSLGSGGYTAKGMEAHFRVNPMFVSGNVRKAIENGDGDFTPAFF
                     HEVPKLLREKRLKCDVVLAQVTPPDEHGYCSLGTSVDYTYEAIKTARTVIVQVNDQFP
                     RTYGEVVHVSEFDYIVEKSQPLFELQPAKIGEVEEAIGKNCASLIEDGSTLQLGIGGI
                     PDAVMLFLTDKKDLGIHSEMISDGTLALYEKGVINGKYKNFDKEKMTVTFLMGTKKLY
                     DFANNNPAVEVKPVDYVNHPAIIMKQHKMVSINSAIQVDLMGQVVAEAMGLRQFSGVG
                     GQVDFIRGVSMGEDGKAIIAMPSITTKKDGTVISKIVSIVDEGAPITTSRNDVDYIVT
                     EYGIAELKGKSLRERARNLINIAHPSVREHLAVEFEKRFKEKY"
     gene            21816..22934
                     /locus_tag="KNP36_002076"
     CDS             21816..22934
                     /locus_tag="KNP36_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybutyrate dehydrogenase"
                     /protein_id="HBF0873949.1"
                     /translation="MEALRVVPKIFYFDTFKEFNEEFKIGKNDLVITNEFIYEPYMKP
                     LGIDTNLIFQEKFGTGEPSDEMIDSMTKEMKKYNFDRIIAFGGGTIVDICKILALDVP
                     EKSIDLFEGEVSPKKVKELVVVPTTCGTGSEVTNVAIAELKSKHTKKGLAVEETYADY
                     AVLIPETVKGLPYKFFVTSSVDALIHAIESYLSPKASPFTEMYSLQAIKMIMDGYKKI
                     VDKGEEERFNHLRDFVLASNYAGIAFGNAGCAAVHALSYSIGGAFHVAHGEANYQFFT
                     EVFKMYSRKKPNGKIIKCTKILADALECDPNCDVYGELEKFLNKLIAKKALREYGMVE
                     SQIDEFTDSTIANQQRLLANNYVELSREEIREIFANLY"
     gene            23221..24141
                     /locus_tag="KNP36_002077"
     CDS             23221..24141
                     /locus_tag="KNP36_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-bromo-4-chloroindolyl phosphate hydrolysis
                     family protein"
                     /protein_id="HBF0873950.1"
                     /translation="MYKSENFSKKSVLINSFLSKFLKIIGWGLVSLFTLSALVLSTIS
                     IIIGWAVILPIQVCAVFLLIGGVCIFKGKRLGDQISRYKKYCTIINNRNIIPVELIAE
                     NTSKSLNFIIKDVQKMIDKNYFINTYIDKRNNQIVLTNEDFVPPRYEDVAYEVKEEEK
                     TDESNEVDTIINKGMNYLTQIKEANKNIKSESMGDKIVQVEDVTSKIFDVVKHDPSKL
                     TQIQKFMDYYLPTTLKLLNSYHTLEEQGIDRENITTTMESIENTMNTIVVAFENQLDY
                     LFEDEAIDISTDITVLENMLVQEGLTSGKF"
     gene            24256..25413
                     /locus_tag="KNP36_002078"
     CDS             24256..25413
                     /locus_tag="KNP36_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HBF0873951.1"
                     /translation="MNNLDDIPVMPTLTLDPFGEESNTNDIDNSDLLMKKDEKDPEEE
                     KLSESERKMVKEFAEKIDITNTNMILQYGAGAQKKVASFSETALKSVKTRDLGEVGDM
                     LTNLVTDLKAFSADEKEQSGFLGIFKKANNKISNLKTKYDSAEVNVDKVSKELQKHQV
                     KILKDIAMLDKMYELNLAYSKELTMYIIAGKQKLKDMKEYEMPKLREKARLSGSTEDA
                     QSVNDMVSLCDRFEKKIHDLELTRMVSLQMAPQIRLVQNSNNLMAEKIQSTIVNTIPL
                     WKNQIVLALGISHLNQAMKAQREVSNMTNELLLKNAETLKMGTIETAKESERGIVDID
                     TIKKTNQSLISTIDEVVKIQHDGRIKRQEAEVELSKIENELKSKLLEFTVK"
     gene            complement(25498..26997)
                     /locus_tag="KNP36_002079"
     CDS             complement(25498..26997)
                     /locus_tag="KNP36_002079"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HBF0873952.1"
                     /translation="MAFYFDTPSHTFSEYLLVPGFSSTDCIPANVSLKTPVTKFKKGE
                     EADIYMNIPLTSAIMQSVSDDKMAIALAKEGGISFIYGSQTIENEAAMVARVKSHKAG
                     FVVSDSNIKPDNTLKDILDLKEKTGHSTVAVTEDGTSTGKLLGIVASRDYRISRMDLD
                     TKVSEFMTPMSSIVYANKDVTLKEANNIIWDHKLNSLPVLDDNGNLMYMVFRKDYSSH
                     KENPLELLDSSKRYVVGAGINTRDFAERVPALVEAGADVLCIDSSEGFSEWQKITLDF
                     IREKYGDTVKVGAGNVVDREGFLYLAEAGADFVKVGIGGGSICITREQKGIGRGQATS
                     IIEVAQARDEYFEKTGIYIPICSDGGIVYDHHITLALAMGADFIMLGRYFSRFDESPT
                     NKVNINGSYMKEYWGEGSARARNWQRYDLGGDKKLSFEEGVDSYVPYAGSLKDNVTLS
                     LSKVRSTMCNCGALSIPELQKNAKLTLVSSTSIVEGGAHDVMLKDNRNL"
BASE COUNT        10661 a         3124 c         5139 g         8402 t
ORIGIN      
        1 acaaaaaaat atacataaga ttaatttatt aagaaataaa atagaaacgt tgtcaaatat
       61 agcttcgata agatatagta cagacacatt taataaattc tacaaagaag aaaaaaatta
      121 ttgggatgaa tatatgcctt tgtatgaaga attaaattca tatttttata atgccattgt
      181 aaattcaaaa tttaaatatg atttgataaa agagtttgga gagcaatttt tcacaatagt
      241 agagtattct ttaaaaagtt tttccaaaga aataataagt gaattgcagg aagaaaataa
      301 attgtgttca gagtatacta gacttttagc ttcagctgag ataatgtttg atgggaaaat
      361 aagaaattta tctggtatgg ggaaattcat gtattctaag aatagaaaaa caagagaatt
      421 agcaaacaaa gcatattata atttctttga agaaaatgaa actaaatttg atgatatatt
      481 tgataaattg gttaaactta gagataagat gtctaaaaaa ttaggttttg aagattttgt
      541 agagcttggg tacattagaa tgatgagaag tgactacaga gaatatatga taaaaaatgt
      601 tagaaaacaa gtactaaaat atgttgttcc aatggcaaat gagctttatg aaaaacaagc
      661 taaaagaatt ggtctagaat atttaagtta catagatgaa ggcgtggaat ttttaacagg
      721 aaatgcaagt ttaaagggag attcaagata cataattaaa aatggtaaaa ggatgtattc
      781 tgaactgtca aaagaaacaa atgaattttt tgattttatg ttagaaaatg aacttatgga
      841 tttagaaacg aagaaaggaa aaggagctgg agggtattgt acttatatac cagattataa
      901 gtcaccattc attttttcta attttaatca aactgctgat gatatagatg tattaacaca
      961 tgaggcagga catgcatttc agttgtatat gtctagatgg attgatatgc cagaaattaa
     1021 ttttccaacg cttgatagtt gtgaaatcca ttcaatgagt atggaattta taacatggcc
     1081 gtggatggat ttatttttta aagaagatac agataagtac aaattcactc acttatcatc
     1141 ttcaattaaa tttatacctt atggagtaat tgttgatgaa tttcaacact atatttacaa
     1201 aaatcctaat gtagataagt caaaacgaaa agaaatctgg agatttttag agaaaaaata
     1261 cttacctcat agaaaatatg gtgataattc ttttttagag agaggttgtt ggtggtttaa
     1321 acaaggacat atatttaaaa atccgtttta ttatatagat tatgtattag ctcaaatttg
     1381 tgcgttacaa ttttggaaaa aaatgattca agatagagat gcaggatgga aagattatat
     1441 aaatatctgt aaagttggag gaacaaaatc atttttagat attgtgagta tgggaaattt
     1501 gtattctcca tttgatgatg gctgtattga gtctattata ggtgatgtta aatcttggtt
     1561 tgatgaaata aatgacagca aattataaaa aattatgaga attttattgt ataaaagtaa
     1621 aaaattaaaa aatatataaa aagtgattat ttgttgtgaa aatagtcttg tttttaacta
     1681 aattgataaa ataaactaaa aaagatttgt acttaaaaaa aaaagaaaat acaagaaata
     1741 tgcaatatca acatttggaa aaaaaagtaa aaatgtatac aaaatacata taaaaaaact
     1801 attgcaaatt ttatagaatg tttatatact taagtcaaca gagatagaaa aaagctattt
     1861 atagaaaaca aaggataaat tgcttaattt taaattttct gaaaaaaata ataatccgga
     1921 tgaagagtat gggagactgc tttataaaaa gcgaccgaag ggacaagttt aatcttactt
     1981 acccaaaaga ttagatgaaa ttctcaggta aaggtgactg tacttggacg gggctctgaa
     2041 aatgatttta acagggaaga caaattggga gatttgtttt tcctgttttt tatttatcaa
     2101 gtaataaata aaagtttgaa agagagtaaa aaaatgataa taattacgaa taatccaaaa
     2161 gtaaaagaag aagttcaagg cagagaagtt ttgtttaaag acacaactta tattggaatc
     2221 ttagaagcaa gtagagattt gatacatgaa ggttatgaac ttttatctca tccactctat
     2281 gggagtgtaa agccaaatga aacaccttac aggactgtta tactaaagaa aggaaatcgt
     2341 ttggatataa actctttaac cttaattgaa gaagcaatca tcactgcaag taaatttcag
     2401 aataataaaa agactccaaa atggacagaa agtgttcaag atgattttag agtaattgat
     2461 tatgatatat tttataatac aatacaaaga atgcagtatg aataaaaaaa ttgttaaaaa
     2521 gttattaaaa cagcctaaat attaaatcta atttaatatt aaataaaatg agaaatttaa
     2581 ttggggagga taagtcaaaa tggaaaatgt gtatgactta gtaataattg gttcaggacc
     2641 agcagggctt gcagcaggtc tttatggagc aagagcaaag ttaaaaactc taatcctaga
     2701 aaaagacaag actggtggac aaattgtaat aacacatgaa attgcaaatt atccagggtc
     2761 agttccaaat gcaacaggac caagtttaat agctagaatg gttgaacagt gtaaagagtt
     2821 tggagcagaa atgctaagag acaacattgt tgatactgag ctagatggag atataaaagt
     2881 tttaaaaggg gaaaaggcag aatatagagc aaaagcagta ataataggaa caggagcaac
     2941 accaagaaag attggttgtc ctggagaaaa agaacttact ggtaaagggg tttcatattg
     3001 tgcaacttgt gatgcagatt tctttgaaga ttttgaagta tttgttgtag gtggaggaga
     3061 cagtgcatta gaagaagcaa tgtatttaac taaatttgct agaaaagtaa caattgtaca
     3121 tagaagacaa ggatttagat gtgctaagag tgttgaagaa aaagcaaaag ctaatccaaa
     3181 gatagagttt ttattagata cagtaattga agaaatcaaa ggtgatggaa tattagaatc
     3241 agttgtattt aaaaataaag ttactggaga aactcatgaa tactttgcag atgaagaaga
     3301 tggaacaatg ggagtatttg tgttcgttgg attagatgct caaactgatt tattcaaagg
     3361 taaagttgat atggatgaaa aaggttacat aataactgat gaagatatga gaactaacat
     3421 accaggcgta tttgcagcag gagattgtag atctaagact ctaagacagg ttgtaactgc
     3481 aactaatgat ggagcaattg catctatagt agctgagaaa tacattgatg aaaaatttgg
     3541 gaactagaat ctgtaaatta agaaatagtg tctgtaaatt taatgaataa tatttaaaat
     3601 taaaattaat atttaaaata aaaataaaaa tttcaagggg gaataagaaa atgttagatt
     3661 tagataaggc tacatttgaa gaagaagttt taaatgcaga aggttttgta tttgttgatt
     3721 tttggagtga aggttgtgag ccttgtaaag ctttaatgcc agatgttcat aaattagctg
     3781 agacttatgg ggataaaata aaattctgta agatggatac aacaaaagct agaagattag
     3841 ctataaaaca aaaagtatta ggtcttccaa ctatggctat atacaaagat ggagaaaaag
     3901 tagacgaagt tactaaggat gatgctacag ttcctaatat agaaaacatg attaaaaaat
     3961 atctttaata tgttgataaa ttattaacat taaaagaaaa aatctatttt tatctgaaga
     4021 taagaagaaa aaggttttta tgtccaactt tgttaaaaaa ataattttaa ataaaataat
     4081 ttttttacaa taaatatttt ttagtaataa aataaagatt taaggcataa aaacacaata
     4141 atatatcttt aaaaaaataa gataaattgt aaaatgatat aattttgaga aaaactcaaa
     4201 tgcatataca caaattaaat aacaggaggt gcaagtatgc gtcttgaatt agggaaaatc
     4261 tttataaaag atattcaatt tggtgatgta acagaagtaa aagatggagt attattcatc
     4321 aataagcaag agatgctaca agaaattggt ggagatgagc atattaaatc tatagatata
     4381 gaattagctc gtccaggtga aagcgtaaga ataacacctg taaaagatgt tattgagcca
     4441 agagtaaaag ttgaaggtaa tgggggaatc ttccctggta tcatgtctaa agttgacact
     4501 gtaggagaag gaaaaactca tgctttaaaa ggtgtagctg ttgtaactac tggaaaaata
     4561 gtaggtttcc aagaaggtat aatagacatg actggagaag gagctaagta cactccattt
     4621 tctaaattaa ataatgtagt agtaatagct gaacctattg atggtttaaa acaatacgct
     4681 catgaaaaag ctgttagaat gataggattc aaagcagcaa tgtacttagg agaagtagca
     4741 agaaatctta ctccagatga agtttcagta tatgaaacta aacctcttct tgaatcaata
     4801 aaagaatatc cagagcttcc aaaagtagga tatgtttaca tgcttcagac tcaaggttta
     4861 ttacatgata cttatgtata tggagtagat gcaaaacaaa tagtaccaac tttattatat
     4921 ccaacagaat taatggacgg agcaattgta agtggtaact gtgtttctgc atgtgacaaa
     4981 aacccaagtt atgttcatat aaacaatggg gttgttgaag acttatatgc aagacatggt
     5041 aaagatataa actttgtagg tgtaattata actaatgaaa atgtttatct agcagataaa
     5101 gaaagatctt caaactggac ttctaaatta tgtaaatatt taggattaga tgcagttata
     5161 gtttcacaag aaggttttgg aaatcctgat actgacctta taatgaactg taagaagata
     5221 gaaatgcaag gtgttaaaac agttatagtt acagatgaat atgctggacg tgatggaggt
     5281 tctcaatcac ttgcagatgc agatgtaaga gctgatgctg ttgtaacagg tggaaatgcc
     5341 aaccaagttg tagttcttcc taagttagat aaagttattg gacatttaga agtagtagat
     5401 gtaatagctg gtggttctga tggaagttta agagctgatg gaactattga agttgaaatc
     5461 caagctataa caggtgcaac taatgaaaca ggatttggtc atttaactgc taaaggatat
     5521 taagaagtat tttattaaac gattgagtaa tgttaataaa acatattata gataattata
     5581 ataagtgtta tagatatata aaaatatatt agaaatataa taaggaggat tattatgagt
     5641 ttacttagta ataaaaaggt tcttataata ggtgaccgtg atggtatacc aggacctgcg
     5701 atagaagaat gtgtaaaaac agtagaagga gcagaggttg ttttctcatc tacagaatgc
     5761 tttgtctgaa cagctgctgg ggctatggac ttagaaaatc aaaacagagt taaagatgct
     5821 gctgataaat tcggagctga aaatgttgtg attttactag gtgctgctga agccgaagct
     5881 gcaggtcttg cagccgaaac agtaactgct ggagatccaa ctttcgctgg accacttgct
     5941 ggagttgcct taggattaag tgtttaccac gttgttgagg aaccaataaa atcattattt
     6001 gatgaaagtg tatatgagga ccaaataagt atgatggaaa tggttttaga agttgaagaa
     6061 atagaagaag aaatgtctgg tataagagaa gaattttgta aattttaatg cctaaaagca
     6121 aaaggggtga aactaagaga tgggaaaact aaaagcagta cattatatta atcagttctt
     6181 tgctggtata ggtggagaag aaaaagctga tactaagcca catgtggcag aaactttacc
     6241 tccaataagt ttacaacttg ataaattatt aggtgaagat attgaaatag ttggaacagt
     6301 agtttgtgga gatagctatt tcaatgaaaa tatagatagt gcaagtgaag aagttttatc
     6361 aatggtaaaa ggttttgaac cacaactttt catagctggt cctgcattta atgctggtag
     6421 atatggggtt gctgctggaa caataactaa agttgtaaaa gatgctttga atataccagc
     6481 tttaacaggt atgtatgttg aaaatccagg agcagatatg ttcaaaaagg atgtttatgt
     6541 agtagaaact tctgattctg cagcaggtat gagaaaggca cttcctaaga tagctaaact
     6601 tgcagtaaaa cttgctaatg gagaagaaat tggaactcct aaagatgaag gatacatagc
     6661 tagaggaata agagttaact acttccatga agacagaggt tctaagagag ctgttgacat
     6721 gttagttaag aaaataaaag gtgaaccatt tgaaactgaa tacccaatgc caaactttga
     6781 tagagttgac ccaagtaaag ctgtaaaaga tttatcaaaa tgtaaaatag ctttagttac
     6841 ttctggtggt atagttccaa aaggaaatcc agatagaata gagtcttctt cagcttctaa
     6901 atatggaact tattctatag caggagttat ggatttaaca gaagagactt atgaaactgc
     6961 acatggtgga tatgacccag tgtatgcaaa tttagatgca gatagagtat tacctgttga
     7021 tgttcttaga gatttagaaa aagaaggtgt aattggaaaa ttacatgaga ctttctatac
     7081 aactgtaggt aatggtacat ctgttgcaaa ctctaaaaaa tatgcttctg aaattggagc
     7141 agcattagtg gctgatggtg tagatgcagt aatattaact tctacatgag gtacttgtac
     7201 tcgttgcggt gcaacgatgg taaaagaaat agaaaaaact ggacttccag tagttcatat
     7261 gtgtacagta gtacctattt cattaacagt aggggctaat agaatagttc caactatagc
     7321 aatacctcat ccacttggaa atccagcgct tgaccctaca gaagaaaaag ccctaagaag
     7381 aggccttgta gaaaaagcat taaatgcttt aactacagaa gtagatggtc aaacagtatt
     7441 tgaaaaataa aaataacaca cacatatatt atatagataa aaatataaac acacactaaa
     7501 aataaaaaat aactatacac aaaaaaataa tatagatttc atgaatggat aaattggagt
     7561 tattcattca tgaaatctta aaaaatgcca aaatacataa acaataatag aatcaaatat
     7621 acaataaaat ataatgatta gagcttttaa taagtttaat aagattaaaa aataagtgtt
     7681 cataaaattt atggaggtgc acaaaatgac ttatccagtt ttaaaagggg caggctatgt
     7741 acttattcat actccagata tgatagtgca aaatggaagt acttgtacag ttgaaagagc
     7801 aacaaatcca gattcagaat ttttaaaaga agtaagtaat catataagaa gttatgaaga
     7861 tgtagttaac tacatgccaa atcaagttta tataggaaat agaagaccag aagaattaag
     7921 agatttacca atgccatggt gtgaacaaaa gattgaggga actagaaatg gtaagtttgg
     7981 agaaataatg cctcaagatg agttcatagc tttaatgcaa ataagtgatg catttgattt
     8041 agtaaaatta tcacaagaat ttattgatga agtaaagcca aaaatcgaaa ataactaccc
     8101 tgaaattgca ccatttgtag gtaaattaaa gggtgatgat atagaagaag gtaaagaatt
     8161 agtagcaaca cacatagctg aaggattata ccatgatgga aaatttgttg gttatgtaaa
     8221 aagagcacat gatgtagatg ttaacttaaa tgcccataca atgtttgaaa atctagtagt
     8281 aaaagcatct ggagttttat ctgctattca aatgctaaga catagcaaaa tagaccctgc
     8341 tgaaatagat tatgttattg agtgttcaga agaagcttgt ggagatataa accaaagagg
     8401 tggaggaaac tttgctaaat caatagctga gatagcagga cttcaaaatg caactggttc
     8461 tgacacaaga ggattttgtg cagcaccaac tcatgcatta attcaagcag cagctttagt
     8521 aaaagctggt atacataaaa atgtaatggt agtagcaggt ggagcaagtg ctaaacttgg
     8581 aatgaatgct aaagaccatg ttaaaaaagg tcttcctgta cttgaagatg ttgttggagg
     8641 atttgcagta cttgtatctg aaaatgatgg tgtaaatcca gttataagaa ctgatttaac
     8701 aggtaagcat actgttggaa ctggttcttc accacaagca gttatgacag cacttataac
     8761 ttcaggtctt gatagagcta atttaaaaat aacagatgtt gatgtgtatt cagttgaaat
     8821 gcaaaaccca gatataacta agccagcagg agcaggagat gttccagaag caaactacaa
     8881 aatgataggg gcacttgctg ttaaacgtgg agacttagaa aagaaagaat tgaaagattt
     8941 tgtttctaac aaaggattac caggatgggc accaactcaa ggacatatac catcaggagc
     9001 tccttatata ggatttttaa tagatgattt aactacagga aatagaaata gagctatgat
     9061 agttggaaaa ggtagtttat tcttaggaag aatgactaac ttatttgatg gagtatcttt
     9121 tatagctgaa agaaatacag gtgttactga agagacttca ggaatatcta aggatgaaat
     9181 taagaagata atagctgaat ctatgaaaaa actagcatta gatatgttag aagaataggg
     9241 gtgaggatat gtcaaaaaaa gtaatcgcag atgtattctt agaagtagct aatgcaatag
     9301 aaagcggcga atttggcaaa aaagtaaaaa ttggtgttac tacacttgga agtgaacatg
     9361 gtgtagaaaa catggttaat ggtgcacaat tagcaaaatc taatttattt gatattgtgc
     9421 ttattggacc aaaagtggaa actgaccttg aagtagttga agttaatgat gaaaaagaaa
     9481 tgcatgcaaa aatggaagaa ttattagatt caggatatat tgatgcttgt gttactatgc
     9541 attataattt tccaataggt gtatctacag taggtagagt aataactcca gcaaaaggaa
     9601 aagaaatgat acttgcaaca acaacaggaa caagtgctac taatagaata gaggcaatgg
     9661 taagaaatgc catttatggt attgctacag ctaaatcaat gggtaacaaa tgcccaaaag
     9721 ttggaatact taatgttgat ggagcaagac aagttgagaa gtgcttaaaa gaattaaaag
     9781 ataatggata tgacatggag tttgcggatt caattagagc agatggtgga tgtgtaatga
     9841 gaggtaatga tttacttgta ggtgcacctg atgttatggt tactgataca ttatctggaa
     9901 atatatttat gaaagtattt tcttcatata ctacaggtgg agattatgaa gctcaaggct
     9961 ttggatacgg acctggagtt ggagaggact atgatagaaa ggtacttata gtatcaagag
    10021 catcaggttc tccggtagta gcaaatgctt taaaatacgc ttatgatgtt gtaaagggag
    10081 atataagtaa tgttgcaaga aatgaatttg caaaggttaa aaaagcaaaa tttgatgaca
    10141 ttatatcctc tcttactaaa aaagaagtta aagctgaaaa agtagaagtt aaaatgccag
    10201 ataaagaaat tgttactcgt caaatagctg gtgttgatat aatggattta gaagatgcag
    10261 tatctgagtt atggaaaaac ggaatctatg ctgaaagtgg tatgggttgt acaggtccaa
    10321 tagttttagt aaatgaagct aaaggagact tagcagttga aactttagtt aaagctggat
    10381 atactgcaaa ataagtacat tttttatatg taaataagaa catatagtta taattttatt
    10441 gattataatt atatgttctt tttattttat atcttgtcaa tatttatata ttaacacaat
    10501 ccatttattt gattctctag ctaatttatt atatttattc agttaaaatt aagctttcta
    10561 actaaataaa aactaatgaa gtattaaaat gaaattgata aaatatgaaa aaattttagg
    10621 aataaagtat ctgttagata aaaataagat taattagtga tataatataa ttaagataaa
    10681 atttattatt tggaggcaaa atcatgagca gagtaaaaaa tgtagtagaa ttgttggaaa
    10741 ctaaaggtgt tgatgcacta tatctaacaa agaaaactaa tgtaaactat ataagtggtt
    10801 ttcctgatga agaagcatat gcagtgattt gcaaagatgg aaacttttta gttactgata
    10861 gtagatatat ggagcttgca gaaaaggttt gcaaagattt tgaaattata aattggcata
    10921 attttgatag aagtgtggca aaggcagtta aaagtgtatg tgataaagtg ggtataaaga
    10981 aacttgggtt tgaaagaact aatatagtgt ttgataaata tgaagaactt aaaaatctga
    11041 ttgagaagga taatggagaa ttaataccta cagaaaatat tgtagagact ttgagatatg
    11101 taaaagacaa agatgaaatc aaaaatacaa gaaaagcttg tgaaatagcg gataaggcat
    11161 tagaagaatt gattccacat ataaaagctg gagttagcga aattgaactg gctacaaagt
    11221 tagagtactt tatgaaaatg aacggagcac aaaatatagg gtttgaaact atactgatat
    11281 caggagcaaa gacttcattg cttcatggta agcctagtga taagattata gaaaaaggtg
    11341 attttgtact tatagactat ggcgctatgt ataatggcta tatatctgat acaactagaa
    11401 cttttatagt tggaggagct tctgaaaagc aattagaaat atataattta gttaaggaag
    11461 ctcaaaatgt aggggttgag aacatgaaag ctggtgtaca tgcgacaatt ccagatgctg
    11521 agataagaaa agttgtcaaa aaatatgaag actattacta tcaaggtata ggacatggag
    11581 tcggtagaga tgttcatgaa gaacctttca ttggtaatta tggtgataaa atcatagaag
    11641 agggatgtat aataacaatg gaaccaggta tttatttccc tggatggggt ggagttagaa
    11701 tagaagatac tgttttgatt actaaaaatg gtccagaaag acttactaaa ttccctaaag
    11761 atttgatgat tttagacaaa taatttaatt tatatatatt tttttacata aaatataaca
    11821 taatctcact attaagctct atttacatat tatagtaaag agggcttaat tttattgtga
    11881 gaggtgatag tatatatgta taaaaaacat aaatttataa aaaatataaa aaaagcctgg
    11941 tataaaatca aattaattga tagatgcctt ataattgtaa tggcaatatt aatgtttcaa
    12001 tctatatata atttatttgt taatgaagta aattcacaag atactacaac tattgatgta
    12061 gtagtaagaa ccacttcagc agctatattt gggtattttt taagtgctaa ttttataaag
    12121 agacctttaa ggaagtatac aaatactgat gtatcttcaa atctttttat agataataat
    12181 ttatccccaa aaggtcaaga gtctaatcaa aataatataa tgaatgtcaa aaataccatt
    12241 ggatttactt cagaagctga taattatgaa aagaaaatac ctattaataa taatgaaggt
    12301 tttgaagaag gagaaactag tgaattgcaa attattatag ctactgtaat ttgtatagta
    12361 gcattaacag tactttttgt tgtaagaaat tttacaacta caacatcagc ttctttaggt
    12421 actatttcac agatgagaga ttttgtctca ggatgcgtgg gttttttgct aggttgtcca
    12481 agtaaacctg attaaaaaag tattatcaat aaaaggtatt ttaaaaagta tcagtataat
    12541 aatatttaga tttaaatgta tacaattata attctaaaca ttctatattg tatttttata
    12601 ctgatactct aaactatact atttattaaa atattttaac attgtattta aacaaaatat
    12661 tatatctgta taatataaat ttagtttata tgaatagatg ccatatactc aataaaaagt
    12721 ttcatactat gagatatgta ttgatttctt ctccaaagaa ccccaatatt cgcagtaatt
    12781 gcacgttcta atggtattga acagagattt tctgtatttt gaaatatttc tttatacaat
    12841 attgttgaag ccaagtcatt ttctagtaaa taacgtatgg tagaaagttg atttgagtgt
    12901 aaaattatat ttggcttagc tttttcaagt ctttttgtaa taatcttata gtgataagaa
    12961 ccttcagata agattacaaa aggtacattt tttaacatat aattcgatat aatgggatgt
    13021 tttgccaatt catttttggg atttgtaact aagtataatt ctgttttata gattgtcttt
    13081 gaatctatat catcataaat atcactgtca attataccaa tacaaaaatc aagtgtagat
    13141 tcttcaatca ttttagctcc aacaaatgtt ggaacttcaa aaattttaag ctctatatct
    13201 ggataaatta cattaaatct aggaagtatt tttgaaagca aaaacgtacc taaaactgta
    13261 ggaataccta ttttgagaga agcttttctc ttttttccta aatcaagtgc gtcacattga
    13321 aaatcctcaa attgttttat aaaatgtttt gacttgtcta aaaaaatttt tccttcaggc
    13381 gttaactcta ttttattacc tattctgtaa aaaagttcaa agccaagttc tttttctaat
    13441 tctttaattg ctaatgttat ggatggttga gaaatatgaa tactttccgc agccttagtc
    13501 atgtttttat atttacagac agtttgaaaa tagtataaat agtttatatt catttggtat
    13561 tagttccttt catttacata ttagtgacaa gtatataatt aacaatagca taagttttgt
    13621 atattgttgt aaaaaaatag aatagtttta aactatcata gcataagttt ttgatatttt
    13681 caatctatta agaatagtgc tattattaaa ttaacaaaag agaatagctg gtatggttta
    13741 gagtaaatca atctatatta cagttatatc aacgaatatc aaaaaattat ctattagaaa
    13801 ataaaaatta tttttacaat taaattgtta attaaatcat aaagaaaaaa gtgatattaa
    13861 caagataaaa tttttttaat cagaaatgtt aatttaataa caaaatagag tattggggag
    13921 aaaggagaaa tatatttttt aataatattt gttaatttaa taacgaaaaa tgaaagggag
    13981 tgatttagtg aagtttgaat tgatggattt tttaatgaat ccttttgtcc ttatgtttgc
    14041 tgcagtaatt acaggaattt tatttggaaa aattaaattt gggaagttta attttggggt
    14101 atcaggagca ttatttacag gattatttat tggatggctt gcatatagct tggggaatct
    14161 aataatagca aaaggggaaa cagcagcagg atataaggca gcaactgtaa tgatgggtaa
    14221 tggaattatt tcttctgact tctttgattt ctttttaata atatttgttg cagcagttgg
    14281 tctattggca gcaaaagata tgaaagctgt attaaagaag tatggagcaa gatttgtaat
    14341 tttaggagtt cttataactt ttataggtgg ctctatgact tatgcaatga ctttactatc
    14401 aagtgataaa ggaagtagtg cttatgaagt ttctggcgtt tacacaggag cattaacaag
    14461 ttcgcctgga ttagctgctg ctttagaaac agctggtaaa catgcagaag atgtatcaaa
    14521 agaatttgaa aaagcttcaa taaaagataa aaaagaaatt ttaaaagtag tcgacccaga
    14581 aggcaaattg gatgtgaata caactacatc actgactcaa gagcaaatag ataagtatat
    14641 tgcatatgct gaagctggtg ttggtatagg tcatgcagtc gcatatcctt ttggagtttt
    14701 aatagtaatc ttaggtgtaa atttccttcc aaaattattt aggatggacc taaaagaaga
    14761 aagaagaaaa tatgagaagg aaatgaagga agcaagagat agtgtttctg gtaaaacgat
    14821 accagaagtt ccatttaata taataacatt tttcttgaca tgtttagctg gatacttagt
    14881 tggaggaata catgtattta tgggaccact agggtacttc acactaggcg caacaggagg
    14941 ttcactaatt gtatctctag ttcttggata tataggtaag ataggggtag taaatttcag
    15001 aatggaagaa aaggttttaa atattttaaa acaaataggg ctagtatttt tcttagcaat
    15061 agttggatta agatatggtg gaaaagtagt tgattcaatt atgacatctg gtatgcacct
    15121 agccttagta gcaatagcag taggtgttac agctatgatg ataggattct tagttggcaa
    15181 atacgtattt aaattaaatt ggattttatt atctggagct gtctgtggtg gtatgacatc
    15241 aacaccaggt cttggagctg ctgttgatgc tcttgatagt gatgacccag cagcaggtta
    15301 tggtgctacg tatccatttg cattattaac taaagttata ttggttatag ttttacacaa
    15361 acttccaatg taaataagat tttatatggg gggatattta tgaataatga aggagcattt
    15421 gaagaattaa gtggaagatt aagaaataaa gaattgtgtg atttaataat gaatgcagat
    15481 gaagctgcta aaattataga ggatggcatg gttattggag ttagtggatt tacaccttca
    15541 ggctatccaa aagcagtacc attagcagtt tcagaaagag ctaaaagtgg agaaaagata
    15601 aaattaaccg tatattcagg agcatcttta ggtccagaag ttgatggagc atggtcagaa
    15661 gcaggtataa ttgaaagaag acttccttat caaactaatt caatacttag aaataatatt
    15721 aataaaggtg ttgttgatta tatagatatg cacctaagtc attctactca atttttaaat
    15781 tatggaacta tacctaaagt agatgtagct atagtagaag cacttgcaat aactgaagaa
    15841 ggaaatatta taccaactag tgggataggt aattctccat cttttataaa aagtgcagat
    15901 aaagtaatag tagagataaa tcttgcaaaa ccaatggaaa tggaaggtat ggcagatata
    15961 tatattacgg aaaatccacc aaatagaaaa ccaatagaaa taaatcatcc taaggataga
    16021 attggaacaa catatatacc ttgtggtttg gataaaattg caggagtagt aattaccaat
    16081 atgcaagata agacccgtcc attgggagtt gtagatgaag cttcgaaaaa aatatcaaat
    16141 aatattattg cttttttaag agaagaagta aaggcaggca gattatcaaa gaatttactt
    16201 cctcttcaat ctggtgtagg aagtgtagca aatgcagtat tatatggatt atgtgaatct
    16261 gaatttgaaa atttaacttg ttatacagag gttgtacagg actctatgtt ggatttaata
    16321 agaatgggta aagttacaat ggcatctact acatctgtaa gtccatctcc agaaggatta
    16381 ataaaatttg aaaaagatat tgattttttt aaggataaga ttatattaag acctcaagaa
    16441 attagtaaca atccagaaat agccagaaga attggtgtaa ttgcaatgaa cactgcaatt
    16501 gaagttgata tttatggaaa tgtaaattct actcacataa tggggtcaaa gatgatgaat
    16561 ggaattggtg gttctggtga ttttgctaga aatggagcaa taactatatt tagtactgag
    16621 tcaattgcaa aaaatggtga tatatcatca atagtaccta tggtatctca cgtagaccac
    16681 actgaacatg atgtaatggt aattgtaaca gaacaaggat atgctgattt aagaggtctt
    16741 gcacctagag aaagagctat aaaaataata gaaaattgtg cccatccaga ttataaagaa
    16801 caacttaggg attatttaaa tagagcttgt aaaagtggag caaaacaaac acctcacata
    16861 ttggacgaag ctttatcatg gcatagtaaa tttatgagta caggtacaat gaaaaaggct
    16921 gaaactttta aaagtgcatt ataaaatatt taataaattg gaggtagatt ttaaatggaa
    16981 aaagcagtgg aaaactttga agatttaagt aaggaataca ttaatggtta tattgagaga
    17041 gcaagaaaag ctcaaagaga gtttgaatgt tatactcaag aacaagtaga taaaatagta
    17101 aaaatagttg gaaaagtagt gtattataat gctgaatatt tagctaaact tgctgtagaa
    17161 gagactggaa tgggagtata tgaagataag gtagctaaaa ataaaagcaa agcaaaagtt
    17221 atatataaca atttaaaaga taaaaaatca gttggtataa ttgatataga tagagaaact
    17281 ggaataacaa aggtagctaa accagttgga gtagtagcgg caataactcc ttgtacaaat
    17341 ccaatcgtta cacctatgag caatgcaatg tttgcactta agggaagaaa tgcaattatt
    17401 atcacacctc atcataaagc aattggatgt agtacaaaaa ctgtagagat gattaatgaa
    17461 gaattagaaa aaataggagc tccagaaaat ttaatacaaa tacttgacca acaatcaaga
    17521 gaaaatacaa gaaatttaat ttcatcagca gatgtagtaa ttgccactgg aggaatggga
    17581 atggtaaaag ctgcgtactc aagtggaaaa ccagcacttg gtgtaggggc aggaaatgtt
    17641 caatgtatca tagatagaga tgtagacatt aaagaagcag tacctaaaat catagcagga
    17701 agaatttttg ataatggtat catttgttca ggtgaacagt cagtaatagt agcagaagaa
    17761 atgtttgata aaataatgga tgaatttaaa aataataaag gttttatagt tagagataaa
    17821 gtacaaaaag aagctttcag aaatgctatg tttgtaaata aatctatgaa taaagatgca
    17881 gtaggtcaat cagttcatac aattgcaaaa attgcaggtg ttgagatacc agaagataca
    17941 aaaataatag taatagaagc tgatggacca ggagaagagg atattattgc aaaagaaaaa
    18001 atgtgtccag ttatatctgc atacaagtat aaaagttttg aagaaggtgt agctattgca
    18061 aaagcaaatt taaatgtaga aggaaaagga catagtgtat ctatacattc aaatacagtt
    18121 aaaaatatag aatatgcagg agaaaatata gaagtatcaa gatttgttat taatcaatgt
    18181 tgtgctacta gtgctggagg aagtttcttt aatggtcttg cacctactaa tactctaggt
    18241 tgtggttctt ggggaaataa cagcatctct gaaaatcttg attataagca tctaattaat
    18301 atttctagaa ttgcttatta tatgccagaa aatgaagtcc ctacagatga agaactttgg
    18361 ggataaaatt tagacaaaaa atattcattc taaattaaag taggaatata ttttaattta
    18421 gaatgaattt aagacataaa ttaaatttaa attagtttat tggactaaat ttaaaatatt
    18481 aagagacata tagaagaagg aagtattata atttaaaata aataaaaaaa tctataaaag
    18541 agaaggagtg gttttattat ggcattaatg acaggagctc aatatattga aagtttgaga
    18601 aaattaaata ctaaggttta tatgtttggt gaagaggtta agaattgggt tgaccatcct
    18661 atgattagac catctataaa ttgtgtagca gcaacttatg acttagctca tgacccagaa
    18721 tatgcagatt taatgacagt tacttcaaat atcacaggtg aaaaaataaa tagatttggt
    18781 catcttcatc aaagtgttga tgatttgata aaaaaagtaa aaatgcaaag actatgtggt
    18841 caaaaaacag cttcttgttt ccaaagatgt gttggtatgg atgcgtttaa tgcagtgtat
    18901 tcaacaacat ttgagtgtga taaagcccat ggaactaatt atcatgataa ttttgtaaaa
    18961 tacttaactt atatacaaga aaacgattta gtagttgatg gagctatgac tgaccctaag
    19021 ggagatagaa gtctatcacc tagtgctcaa cctgacccag atatgttcct tcatatagta
    19081 gaaagaagag aagatgggat aattgtaaga ggagcaaagg cacatcaaac tggttcaata
    19141 aattcacatg agcaccttat aatgcctact ataagtatga ctgaagcaga taaagactac
    19201 gctgtatcat ttgcagttcc ttcagatgct gaaggagtgt ttatgattta tggaagacaa
    19261 tcttgtgaca ctagaaaatt agaagaaggt gcagatgttg atttaggaaa taaggagttt
    19321 ggaggtcaag aagctttagt agtatttgat aatgtatttg ttccaaatga tagaattttc
    19381 ttatgtggag aatgggattt ctctggtatg ttagtagaga gatttgcagg ataccataga
    19441 caaagttatg gtggatgtaa agtaggagta ggtgatgtaa taataggagc agcagcttta
    19501 gcagctgatt ataatggagc aaacaaagct tcacatataa aagataaact aatagaaatg
    19561 actcacctta atgaaagctt atattgctgt ggtatagcat gttcatcaga aggtcacaaa
    19621 acagaagctg gaaactatca aatagattta cttcttgcaa atgtgtgtaa acaaaatgta
    19681 actagatttc cttatgaaat agtaagactt gcagaagata tagctggagg gcttatggtt
    19741 actatgcctt cagaaaaaga ctttaaatca gaccttaaag ttggaacaag tggaatgact
    19801 attggcgaag tatgtaacaa gtattttaaa gcttcttcag tggcttcaac agaagaaaga
    19861 atgagaatat taagattctt agaaaatata tgccttggtt catctgctgt tggttataga
    19921 actgagtcaa tgcatggggc aggttcacca caagctcaaa gaataatgat ttcaagacaa
    19981 ggaaacataa atcaaaagaa agaattagct aagaaaattg cgggaataaa aaaagaggaa
    20041 gctttaaatt tataaaaagt tgatatataa agggaaatta tatattaatg tgtgttaatt
    20101 aatgaaaaaa tatgtagtat aagagatagt tataaaatta tggtggtttt tagctaagta
    20161 aagaaatttt taataaggag aatttacaca tgacctgtgg agttagattt tgtgggggct
    20221 gtaaccctag atacgaaaga gggaaggctc ttacaataat caaagagcac ttcaatggta
    20281 gggtagattt tagtatagca caagagaacg tcgagtatga tttgttactt ataattggag
    20341 gatgcgcaac tctatgcgca tcctatcaac aatataaagt gaaaaatgaa tgtgttaaga
    20401 tgtgggattt tagccatata gaaagagtta taaatgtgat tgaatcagca atttgtgaaa
    20461 cttaaaaaag ctaaatgggg ggatttcatt gagttggcaa gaattgtatc aaagtaaatt
    20521 atgtagtgct acagaagctg taaaacagat taaaaacggt gatactgtag tatttgcaca
    20581 ttgtgtaggt gaacctcctg cactagtaga agctatgatt gaaaatgctg aacaatataa
    20641 agatgttgag attaaacata tggtaagctt gggtagtggt ggatatactg ctaagggaat
    20701 ggaagctcat tttagagtaa atccaatgtt tgtaagtgga aatgtaagaa aggcaattga
    20761 aaatggagat ggtgatttta cacctgcatt cttccatgaa gtaccaaagt tgcttagaga
    20821 aaaaagatta aaatgtgatg ttgttttagc acaggtaact ccaccagatg aacatgggta
    20881 ttgtagctta ggaacatcag ttgattatac ttatgaagcc attaaaactg ctagaacagt
    20941 aattgttcaa gtgaatgacc agtttcctag aacctatggt gaggtagtcc atgtatcaga
    21001 gtttgactat atagtggaaa aatcacaacc tttatttgaa ctacaacctg caaagattgg
    21061 agaagtagaa gaagcaattg gtaaaaattg tgcttcatta attgaagatg gctctacttt
    21121 acagctaggg attggtggga taccagatgc agttatgtta tttttaactg ataaaaagga
    21181 tttagggatt cattcagaaa tgatttcaga tgggactttg gccctttatg aaaaaggtgt
    21241 tataaatggt aaatataaaa attttgataa agaaaaaatg acagttacct tcttaatggg
    21301 tactaaaaaa ttatatgact ttgcaaataa taaccctgca gtagaggtaa aaccagtaga
    21361 ctatgtgaat catccagcaa ttataatgaa acaacataag atggtttcta taaattctgc
    21421 tatacaagtt gatttaatgg gacaggtagt tgcagaggct atgggactta gacaatttag
    21481 tggtgttgga ggtcaagttg actttatacg tggagtgtct atgggtgaag atggaaaggc
    21541 aattatagct atgccttcaa taactacaaa aaaagatggt acagtaattt caaaaatcgt
    21601 atctattgtg gatgaaggtg cacctataac gacatcaaga aatgatgttg actatattgt
    21661 aacagaatac ggtatagcag aattaaaagg aaaatctctt agagaaagag caagaaattt
    21721 aataaatata gctcatccaa gtgtaagaga acatctagca gtagaatttg aaaagagatt
    21781 taaggagaaa tattaataat agaggggtgt taataatgga agcacttaga gtagttccaa
    21841 agatatttta ctttgataca tttaaagaat ttaatgaaga atttaaaata ggaaaaaatg
    21901 atttagtaat tactaatgag tttatatatg agccatatat gaaacctctt ggaatagata
    21961 caaatttaat ttttcaagaa aagtttggaa caggtgaacc atctgatgaa atgatagact
    22021 ccatgacaaa ggaaatgaag aaatacaatt ttgatagaat tattgcattt ggaggaggaa
    22081 caatagttga tatatgtaag atattagcac ttgatgttcc agaaaagtct attgatttat
    22141 ttgaaggaga agtatcacct aaaaaagtaa aagagttagt agtagttcct acaacatgtg
    22201 gtacaggtag tgaagtaaca aatgtagcta ttgcagagtt aaaatctaaa catactaaaa
    22261 aggggcttgc agtagaagaa acatatgcag actatgcagt gttaattcca gagacagtaa
    22321 aagggttacc ttacaaattc tttgttacaa gttcggtaga tgctcttata catgctattg
    22381 agtcttatct ttctccaaaa gcaagtccat ttacagagat gtattctcta caagcaataa
    22441 aaatgattat ggatgggtat aagaagatag ttgataaagg agaagaagag agatttaatc
    22501 atcttagaga ctttgtactt gcatcaaatt atgcaggaat tgcttttgga aatgctggtt
    22561 gtgcagcagt tcatgcacta tcttattcaa taggtggagc tttccatgtt gcacatggtg
    22621 aagcaaatta tcagttcttt actgaagtat ttaagatgta ttctagaaaa aaacctaatg
    22681 gaaaaattat aaaatgtaca aaaattttag cagatgccct tgaatgtgac cctaactgtg
    22741 atgtttatgg agaattagaa aagtttttaa ataaattaat agctaaaaaa gctttgagag
    22801 aatatggaat ggtggaaagt cagatagatg aatttacaga tagtacaata gcaaatcaac
    22861 aacgactact tgctaataat tatgtagagc ttagtagaga ggaaataaga gagatatttg
    22921 caaatcttta ttaatacaat tttttattta tatgtatagt caacataaac aatgctaatt
    22981 atatttatgt acaaataaaa ataagggaac ttaaatttta attaaagtta agttctctta
    23041 tttttatatg gagttaaata taagtatatt tttaatttaa aatatgctta tatttaagtc
    23101 tattacttta tttgaaacaa tttgtagaat ttcaaattcc ttgacagtaa taagtaagta
    23161 attgtataat caaactgcaa tatattaata atattagtga aaatgaaagg attataaaat
    23221 atgtataaat cagaaaattt ttcaaaaaaa tctgtattaa taaattcatt tttaagtaaa
    23281 tttttaaaaa taattggatg gggtttggta agcttattta cattatcagc cttagtactt
    23341 tcaactattt ccattataat tggatgggct gtaatacttc ctattcaagt atgtgcagta
    23401 tttttactta taggaggagt ttgtattttt aaaggtaaga gattaggaga ccaaatttct
    23461 cgttataaaa aatattgtac aattataaac aatagaaata ttattccagt agaacttatt
    23521 gcagaaaaca catctaaatc attaaatttt ataataaaag atgtacaaaa gatgatagac
    23581 aaaaactact ttataaatac ttatattgat aaaagaaata atcagattgt gttaacaaat
    23641 gaagattttg ttccaccaag atatgaagat gtagcatatg aagtcaaaga agaagaaaag
    23701 actgatgaat ccaatgaagt tgatacaatt ataaataaag gaatgaatta tctaacacaa
    23761 ataaaagaag ctaataaaaa tattaaatca gaatcaatgg gcgataaaat tgtacaagta
    23821 gaagatgtta caagtaaaat atttgatgtt gtaaaacatg acccatcaaa acttactcag
    23881 atacaaaaat ttatggatta ttatcttcca accactttaa aactattaaa ttcatatcat
    23941 acattggaag aacaaggaat tgatagagaa aatataacaa caactatgga aagtattgaa
    24001 aatacaatga atacgattgt agtagctttt gaaaatcaat tggactatct gtttgaagat
    24061 gaagccattg atatttctac agatattact gttttagaga atatgttagt ccaagaagga
    24121 ttaacgagtg gtaaatttta acttcaatag aaaaaatatt ctgttatttt taaacaatta
    24181 attagtcata aagtataaaa tgtgtattat ataagttaat cagtacttta tgaaggaaga
    24241 ggagagaaag atacaatgaa taatttagat gatataccag ttatgccaac tttgacactt
    24301 gacccatttg gagaagaatc aaacactaat gatatagata attctgactt attaatgaaa
    24361 aaggatgaaa aagacccaga agaagaaaaa ctgtctgaat ctgaacgcaa gatggtaaag
    24421 gaatttgcgg aaaaaataga tattacaaat acaaatatga ttttgcaata tggagctgga
    24481 gctcaaaaaa aggtagcaag tttttctgaa acagctttaa agagtgtaaa aacaagagat
    24541 ttaggagaag ttggagatat gcttacaaat ctagttactg atttaaaagc attttcagca
    24601 gatgaaaaag aacaaagtgg ttttttagga atttttaaaa aggcaaataa taaaatttca
    24661 aatttaaaaa ctaagtatga tagtgcagag gtaaatgtgg ataaagtaag caaagagctt
    24721 caaaagcatc aggttaaaat attgaaagat atagcaatgc ttgataagat gtatgaattg
    24781 aacttagctt actcaaaaga gcttactatg tatattatag caggaaaaca aaaattaaag
    24841 gatatgaaag aatatgaaat gccaaagttg agagaaaaag ctcgtttatc tggttcaaca
    24901 gaagatgctc aatctgtaaa tgatatggtt tcactttgtg acagatttga aaagaagatt
    24961 catgacttag aattaactag aatggtatcg cttcaaatgg ctcctcagat aagattggtt
    25021 caaaatagta ataatctgat ggcagaaaag attcaatcaa ctatagtaaa taccattcca
    25081 ttatggaaaa atcaaatagt gcttgctctt ggaatttctc acttaaatca agctatgaaa
    25141 gcacagcgtg aagttagtaa tatgacaaat gagcttttat taaagaatgc agaaactttg
    25201 aagatgggaa caatagaaac agcaaaagaa tcagaaagag gaattgtaga tatagacaca
    25261 attaagaaaa ctaatcaatc tctaatatct actattgatg aggtagttaa aatacaacat
    25321 gatggtagaa taaagagaca agaagcagaa gttgaattat caaaaataga aaatgaactt
    25381 aaaagtaagc ttcttgaatt tacagttaaa taaaaattat actaatataa aaagagactg
    25441 tctcaaaata gagataagtc tctttttcat tgtttaaatg attaaagtat atttatatta
    25501 taaatttcta ttatctttta acataacatc atgagctcca ccttcaacta tactagtaga
    25561 agatacaagt gtaagtttag catttttttg aagttcagga atgctaagtg ctccacagtt
    25621 acacatagta gaacgaactt tacttaaaga aagagttaca ttgtctttca aagaaccagc
    25681 ataaggcaca taagagtcaa caccttcttc aaaagaaagt ttcttatctc caccaaggtc
    25741 atatctttgc cagtttctag cacgagcaga accttctccc caatactctt tcatataact
    25801 accatttata ttaactttgt tagttggact ctcatcaaaa cgagagaagt atctaccaag
    25861 cattataaaa tctgcaccca tagctaaagc taaagttata tgatggtcat aaacgatacc
    25921 accatcagag caaattggaa tataaatacc tgttttttca aagtattcgt ctctagcttg
    25981 agcaacttca attatagaag tagcttgtcc acgtcctata cctttttgtt cacgagttat
    26041 acatatagaa ccaccaccaa taccaacttt aacgaagtca gcaccagctt cagctaggta
    26101 aaggaatcct tcgcggtcaa ctacatttcc agctcctacc ttaactgtat caccatattt
    26161 ttcacgaatg aaatcaagtg ttattttttg ccactcagaa aaaccttctg aagaatctat
    26221 acataaaaca tcagcaccag cttcaactaa agcaggaaca cgttcagcaa agtctctagt
    26281 attaatacca gctccaacta catatctctt agaagaatct aaaagttcaa gtggattttc
    26341 tttatgagaa gagtaatctt tacggaatac catatacata agattaccat tatcatcaag
    26401 tacaggaaga gaattaagtt tgtggtccca tataatattg tttgcttcct ttaaagtaac
    26461 atctttgtta gcataaacta tagatgacat aggagtcata aattcactaa ctttagtatc
    26521 taaatccata cgacttatac gataatcacg acttgcaaca atacccaata atttaccagt
    26581 tgaagttcca tcttcagtaa cagctactgt agaatgtcca gttttttctt ttaagtcaag
    26641 tatgtctttt aatgtgttat caggtttaat atttgaatca cttacaacaa aaccagcttt
    26701 gtgggattta acacgtgcta ccatagcagc ttcattttca atagtttgag aaccgtatat
    26761 aaatgaaata ccaccttctt tagcaagtgc aatagccatt ttgtcatcag aaacagattg
    26821 cataatagca gaagtcaaag gtatattcat ataaatatct gcttcctcgc cctttttaaa
    26881 tttagtaaca ggtgttttta aacttacatt agcaggtata caatcagtag aagagaaacc
    26941 tggtacaaga aggtattcac tgaaagtatg tgatggtgta tcaaaataaa acgccatttt
    27001 ttaatcactc cttatatttt tatacttttt ataattgata gtattaatta taacttattc
    27061 tttaatttta ttaaagtatt ttgtcaaata ttgagatttt tgaaaaattt aaactatttt
    27121 aattaaattt gtttaatata tattgcctta tagggtaaag ttgtatatta aataatgttt
    27181 agtgtttaat agtagctaat ttaaaattaa tctttagtga ttcatataat tacatttgta
    27241 tagtttacat tgataatatt actagagagt gcataaacct caaaaataca gataaattaa
    27301 atctatatta gtatatccaa aagtac
//
LOCUS       DAEHWM010000047        26966 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.048, whole genome shotgun sequence.
ACCESSION   DAEHWM010000047 DAEHWM010000000
VERSION     DAEHWM010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26966)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26966)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26966
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.048"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            119..490
                     /locus_tag="KNP36_002080"
     CDS             119..490
                     /locus_tag="KNP36_002080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CidA/LrgA family protein"
                     /protein_id="HBF0873953.1"
                     /translation="MKVFNQLVIILSIWVIGEYISSFIQGIILIPGSIVGMLLLFLLL
                     QFKVLDLSSIENVSGFFLDNMAIFFIPAGVSLIKSLDLIRENVLVLLLVICLSTLIVM
                     YTTGIIVEKMIKKKEEGQKNV"
     gene            483..1172
                     /locus_tag="KNP36_002081"
     CDS             483..1172
                     /locus_tag="KNP36_002081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LrgB family protein"
                     /protein_id="HBF0873954.1"
                     /translation="MYNVLQTPVFGIIVTIVFFNLGRYIQRKTSNPICNPLLIAIVGI
                     ILFLSISKIPYENYKIGADSLNFFLGPVTVVLAVPLYKQFELFKKHMFEIIVGIGCGI
                     VISFVSVLIIGKIANSDVSIINSLIPKSITTPMGISLANSLNGVESITVVAIIFTGIF
                     GGMVASTVFKLGNINHPVAKGIALGTSAHALGTTKAFELGEIEGAMSGVSIGVSGTIT
                     VILIPIIMNFI"
     gene            1692..2558
                     /locus_tag="KNP36_002082"
     CDS             1692..2558
                     /locus_tag="KNP36_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBF0873955.1"
                     /translation="MSEVKNTLQKHPVLRYSTMLFGMLMTSIGINGFLRPAHLLSGGA
                     TGIATSINYLTNINVGLLTFLINIPIFILGFIYLEKEFCISSLVNMIVFSLLLGATQE
                     ISNIIPIHDILLQSVYGGILSGLGVGVVFRTRSSQGGTDIIAAILKIKKNIEMKDTAL
                     AINGLIVLTGSFLFGLDLALYTLIGLFLNAYSMSFIKDAMNYQKSVMVMSNEVDLIAE
                     DIMKSLVRGVTFLDAEGAYTHQKKKIIYTIVSSNEIPKIKDIALKYDKKAFISVNDVT
                     EVKGRGFKAKDL"
     gene            2800..3609
                     /locus_tag="KNP36_002083"
     CDS             2800..3609
                     /locus_tag="KNP36_002083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873956.1"
                     /translation="MNLSKEYVNLYDNYLKYINEVNKEIRSIKNMKKRVLKRGDFAPE
                     NEVLELEGKTIRDIDDVDTKKPKNKIYKFSNGDVYVGKFLEGKMEGKGSYTFFVDEGT
                     VMEYIGEFKEDKKNGKGNFIFSNGNEYIGYFEEDMMSGIGNMLYSSKDEYIGTWKNGK
                     KDGKGIYKWSDGCIYAGEFKGGKMEGYGICYNSKGEVLYEGEWKNNLIHGKGTYIWEK
                     GKKYIGEFMHGKKHGQGTFYLNNELVYEGTWKFDKPSIFDRTLDEIFSLRL"
     gene            3753..4817
                     /locus_tag="KNP36_002084"
     CDS             3753..4817
                     /locus_tag="KNP36_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase"
                     /protein_id="HBF0873957.1"
                     /translation="MKRLIALVLVVLIVLFYSPELLKEGYDLKEKFFQSEIWNEFLDK
                     ININDNSKKDKKEKSQNLQSNNTEGENLGESDIKNFEKISLGDNLSYVLSSIGKPGRI
                     DISEYGFDWYVYNQYGKEFAMVGLENDEVVALYSNSINSCENQDIKLNQDRQTVRTKI
                     TPLKYKRKGNTRYIINSENQYDIISKEGKYITIFYDIHEENRVCSYLIIDKSTEDEFK
                     NLYPDDSEELKKCFELEVIDLVNSVRNQRGLNSLRYSEQATLSSRKHSEDMRDNNFFD
                     HVNKKNETPFDRMKREGIVYTSAGENIAAGQINAIYAHEAWMNSEGHRKNILGNYNNI
                     GVGVIFGGSYKTYYTQNFYK"
     gene            4845..5564
                     /locus_tag="KNP36_002085"
     CDS             4845..5564
                     /locus_tag="KNP36_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0873958.1"
                     /translation="MTSWKKKTVYKCLIAVVLFCGIVLISNFSKVSALMMDTNGNVLI
                     KHGSREKKLIAITFDDGPHPKETSQVLDVLKKYNVKATFFIAGKHAKWYKEPLVRASK
                     EGHEIGNHTFNHPDISNLSSSQIEEEIVKCEDILKEVTGKKPTLFRPPFGSYREKELI
                     EIAKKHDYKVVLWTGVDVKDWKNPGANSIADKIINKVQNGDIILLHDYATNDTVEALD
                     MFIPKMIEKGFKFVTVSELIK"
     gene            5588..6172
                     /locus_tag="KNP36_002086"
     CDS             5588..6172
                     /locus_tag="KNP36_002086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HBF0873959.1"
                     /translation="MILMIDNYDSFVYNLVQYIEELGETVVVKRNNEIKISDIEELNP
                     EVIVLSPGPCSPKEAGICIDIVEHFKGKKPILGICLGHQTIGHVFGGDIIKAQQPVHG
                     KVYSINHTNKGVFRGLKNPLNVTRYHSLIVDSNTVPKELEITAITDKGEIMGIRHKKY
                     LIEGVQFHPEAILSEYGHEMLKNFITEARERVHM"
     gene            6174..7523
                     /gene="pabB"
                     /locus_tag="KNP36_002087"
     CDS             6174..7523
                     /gene="pabB"
                     /locus_tag="KNP36_002087"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HBF0873960.1"
                     /translation="MIREINTKLNSFEIFTIFRNEHDSFILDSAMDKEKLGRYSFISS
                     QPFKVLKYKDTDENPLEVLKEELHKYRVVNDTNLPFVGGAVGYLSYDLGNYIENLPRT
                     AVDDIEMPDMYFGFYNHVIVIDHLVQKTYIATPNIDIELEEKIIDDIEQRILKEEKKG
                     IDSICYEEKEVTPIRLKSNFTKEEFKNAVQSVREYIRQGDIYQANLTQRFSGETELTS
                     FELYRDLRRFSPAPFGAFLNFEDAHILSNSPERFIRCVNKRIETRPIKGTRPRGKDKE
                     EDLRLQQELRNSEKDRAELLMIVDLERNDIGRISKTGSVKVPELFVIEPYANVNHLVS
                     TVVGELKDDKDATDVIKATFPGGSITGAPKIRAMEIIDELEPTQRNVYTGSIGYIGFN
                     GDMDFNIAIRTIIKNDKKVYFQVGGGMTWDSDPDEEYQETLDKAKSIMKALRGYYEE"
     gene            7513..8256
                     /locus_tag="KNP36_002088"
     CDS             7513..8256
                     /locus_tag="KNP36_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class IV"
                     /protein_id="HBF0873961.1"
                     /translation="MKNNVGFDSSLSKFGIGLFETIRVKNGIAVDLDIHIERMLSSIN
                     CLDLDIKYKKDFLINEIVTYIKKENVINKALRITVFDEGYNISIRDIPYNQETYEKGF
                     KLAISPIVRGNSLIHRHKTTNYFENIYTKNIANKTGYNDGIFLNSEGVILECSMSNIF
                     FVKGERVYTPSDRLPILNGIIKKRIIEICDELHIELIENEINISEISSFDFVFVTNSL
                     MGAIKVTEIDKIKFNKENVVFDKIVKLLE"
     gene            8290..8991
                     /locus_tag="KNP36_002089"
     CDS             8290..8991
                     /locus_tag="KNP36_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873962.1"
                     /translation="MIGCIYEVYNEEITKIIENQNTLAVYLVGSSKDVDFTLYDVEIN
                     DIDVFVFVKEGEKQERILFKKKGIEFDVNYFSKDGVKKLLSNREYFFVKEMKDAKVLF
                     DRENISHIIKDISRNIYLEGPSKMSLEEKSFIKQDIGAKISNLKNKEKFDVFEYHFLT
                     NLYLKDIIIGYFNINDKWVPKDKKLLKVLKKENNELFELVSKVSENYDYQRLLDVYNY
                     IFKEIETKEVIKLIF"
     gene            9017..9589
                     /gene="folE"
                     /locus_tag="KNP36_002090"
     CDS             9017..9589
                     /gene="folE"
                     /locus_tag="KNP36_002090"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HBF0873963.1"
                     /translation="MNKVDKEKIQHAVREILEAIGEDPDREGLIETPNRVARMYEEIF
                     SGLSEEPRDHLKVLFADEKHEELVLVKDIPFYSCCEHHLVPFFGKAHIAYLPKGGRLT
                     GLSKLARVIDTLAKRPQLQERITKNAADIIMEELQPYGVLVVVEAEHMCMTMRGVKKP
                     GSKTVTSAVRGIFEKDIASRAEAMSLITMK"
     gene            9653..10444
                     /gene="folP"
                     /locus_tag="KNP36_002091"
     CDS             9653..10444
                     /gene="folP"
                     /locus_tag="KNP36_002091"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HBF0873964.1"
                     /translation="MFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQG
                     ADIIDLGGESTRPGHSYVDSDEELRRVIPVIKKLKQELDIPISIDTYKADVAEEALKL
                     GVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSIEMA
                     MSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPV
                     EPKKRLEGTIATTVLGIRDGVDIVRVHDVYENLMAARMTDAIYRK"
     gene            10455..10820
                     /gene="folB"
                     /locus_tag="KNP36_002092"
     CDS             10455..10820
                     /gene="folB"
                     /locus_tag="KNP36_002092"
                     /EC_number="4.1.2.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroneopterin aldolase"
                     /protein_id="HBF0873965.1"
                     /translation="MDKILLSNLGFYGYHGVLKEENFLGQKFFVDMELYIDSREAGLS
                     DDINKSVSYAEVYNVVKDITENKQFNLLEALAENIAEEVLNKFILINGVMVRVRKPEA
                     PVNGIYDYFGVEIRRTRDE"
     gene            10813..11319
                     /gene="folK"
                     /locus_tag="KNP36_002093"
     CDS             10813..11319
                     /gene="folK"
                     /locus_tag="KNP36_002093"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HBF0873966.1"
                     /translation="MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETK
                     PWGYTEQADFLNMCVEIETEFEPYELLEYCQEIERELHRERIVHWGPRTIDVDVLFFN
                     DVVSTDERLTIPHPRIQDRAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKEL
                     VGYERKPI"
     gene            11300..12085
                     /gene="aroF"
                     /locus_tag="KNP36_002094"
     CDS             11300..12085
                     /gene="aroF"
                     /locus_tag="KNP36_002094"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HBF0873967.1"
                     /translation="MKENLFNNNSKIEINTNNKKITVKKDKLIIAGPCAIESYEQLLE
                     TAKFVKSQGANILRGGAYKPRTSPNSFQGLKKEGLEILKAVKDEVGMAVITELMDVRD
                     MDELYSISDIIQIGSRNMQNFTLLSEVGKQNKPVMLKRGIASTITEWIGASEYIAIEG
                     NSNIIMCERGIRTYNDYTRNTLDLAAVPIIQKETGLPVVVDPSHATGVRYLVKPMSLA
                     SFACGADGIMVEVHPDPENALSDGAQSLCFNEFEDLMKSINNY"
     gene            12340..14130
                     /locus_tag="KNP36_002095"
     CDS             12340..14130
                     /locus_tag="KNP36_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HBF0873968.1"
                     /translation="MNDIKDIIEEIKARCDIASIISEYMNIKQSGANYKGLCPFHGEK
                     TPSFYINTSKQIYKCFGCGEGGDVINFVMKMENLDFMDAVKILANKCGIEINTNMNEE
                     TRIKIEKSKKFQDIHTEAARFYLSNLLGSKNLGYEYLRIRGLDDKIIKKFGLGFSLDS
                     WNSLMNTLISKGYKKQDLLECGLIAKNRDGTNCYDKFRNRVMFPIFDYRGNIIGFGGR
                     VLDDSLPKYLNSPDTLIFNKKQNLYGLNFARKNLESKTIVLVEGYMDLISLYQYGIKN
                     VVATLGTALTEQQGILIKRYADTAIISYDSDEAGIKATLRAIDILTKLGINVKVLDLK
                     DAKDPDEFVRKYGLSDYKKAMDVSTHYIKYKIDHLKKEFNIQKDEERVKFAKEASKII
                     KQLTSPVEIDFYTKYLSNQIDINVESIKREVYGKNYNKPYNNKNQKKIEEKVIEKVEV
                     RQDGKQLVEETLIKIMLEDKKIREIALLKVEESDFLLKESKEILNYMIKNQELDKITI
                     DKLKSLNISEEYLKELNSISLNSINLENTKEIEGIITNIRKNSLEEQINSLLREQQEL
                     ENNNDMKEVDGRVMEIALKIVEINKILKSL"
     gene            14148..15314
                     /gene="rpoD"
                     /locus_tag="KNP36_002096"
     CDS             14148..15314
                     /gene="rpoD"
                     /locus_tag="KNP36_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HBF0873969.1"
                     /translation="MENKSNKKELKKVTAKTLIEKGKKQGSLTLAEIMEAFSETELDK
                     DQVENLYETLGNLGIEITETKNYKADIDFSVADDDLSIGHLDEDAEAISHDDSSAIEI
                     ETVDLSLPKGISIDDPVRMYLKEIGKIPLLKPHEEVEFARRMHEGDEIAKQRLVEANL
                     RLVVSIAKRYVGRGMLFLDLIQEGNLGLIKAVEKFDYTKGYKFSTYATWWIRQAITRA
                     IADQARTIRIPVHMVETINKLIRVSRQLLQELGRDPKPEEIAKEMEMTEDKVREIMKI
                     AQDPVSLETPIGEEEDSHLGDFIPDDDAPAPAEAAAYSLLKEQIEDVLGSLNDREQKV
                     LKLRFGLEDGRARTLEEVGKEFDVTRERIRQIEAKALRKLRHPSRSKKLRDYLD"
     gene            15479..16168
                     /locus_tag="KNP36_002097"
     CDS             15479..16168
                     /locus_tag="KNP36_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBF0873970.1"
                     /translation="MKLTDRLLKIASLVSDGKKIADIGTDHGYIPVYLLKEGKVPFAV
                     LADVNKGPLDNAHKEVIQNNLLDKVDLRLGSGIEILEIGEVEEVIIAGMGGILISELL
                     EAKKEVAHNVEKLILQPMQAQEELRYYLLNNGYEILEEVLVREDFRIYEIIVAKYTGK
                     NTIIEDEIYYEVGIKLLENKDSLFNDFIEKKIKTYSSIVNKLEGKNGEAIDKKRKESE
                     VAIKKLENLIK"
     gene            16182..17279
                     /locus_tag="KNP36_002098"
     CDS             16182..17279
                     /locus_tag="KNP36_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HBF0873971.1"
                     /translation="MLLKSLTRKIEKKYPLNLAEDWDNVGLIVGDFDMDVKKVLVSLE
                     ANEDVIDEAISKNIDLIVTHHPFIFGKINKINSGDLKGRLIQKLIKNDISLYSMHTNF
                     DIAFDGLNDYFMEIMEFGNSKVLDITKSENLYKLAVYVPHNYSDELRKVLSNSGAGHI
                     GNYSDCTFSTEGEGQFKPLEGSNPFLGSVNDIETVNEVKIETVVPQKLLGGVISSMLD
                     AHPYEEVAYDLYKLENKGEIFGLGRISKLDKSMTLESLSRKIKEKLNMKHIRVVGNLS
                     TDITKVAVVTGAGSEFVKKAKRQGAEVLITGDVKYHEAQDALDIGMCIVDCGHFDTED
                     IFKNVMKRFLDEFSEIEVIKSNVYLNPFSTI"
     gene            17342..17914
                     /locus_tag="KNP36_002099"
     CDS             17342..17914
                     /locus_tag="KNP36_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBF0873972.1"
                     /translation="MKVAVIFHSVCGSTYLLAREYKEALEEMNIEVDIFRVSDEVAKT
                     LPQYYLINSKEYKDEFESINVIKSGKEILDYDAIFMGSPTYYGNVSGPMKMFMDSFSD
                     IWVGAPLSGKIFGCFATAGSQHGGGELALQAMNIFAQHMGMTLLSVPCSVRGGYPAYG
                     ILHIAGDNSDIRPNDDAKIGIRDYLKRLNI"
     gene            complement(17974..18441)
                     /locus_tag="KNP36_002100"
     CDS             complement(17974..18441)
                     /locus_tag="KNP36_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBF0873973.1"
                     /translation="MFKEMRLKKREMTKEDTVEVLKNGEFGTFSTISENGYPYGVAVN
                     YVYFNDSIYFHCARNGHKLDNISKNNKVSFLVVANESVIPDKFSTTYSSAIVFGKACT
                     VENEEKKNALVEIIKKYSKGFFEEGMKYIEKDMNLTTVVKIEIDHISGKASRL"
     gene            complement(18827..19303)
                     /locus_tag="KNP36_002101"
     CDS             complement(18827..19303)
                     /locus_tag="KNP36_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HBF0873974.1"
                     /translation="MLSKAEIKYFNECASEILSSEKVQLMRTFPHHGNVSCLEHSLSV
                     AYYSYLLCKKLHLSVDIQSVIRGALLHDFFLYDWHYKGDRKGLHGFTHPREALKNATL
                     FFQINEKETDIILKHMWPLTVKPPRYKEAFIVCLLDKFCCLVETLKIHSLLSPYHV"
     gene            complement(19423..20514)
                     /locus_tag="KNP36_002102"
     CDS             complement(19423..20514)
                     /locus_tag="KNP36_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1648 domain-containing protein"
                     /protein_id="HBF0873975.1"
                     /translation="MSKIECLFTIFPVLILMYATFYFIPYFVGKKHIYGVSIDQEHKN
                     YNYFIKLDKEFKKLLSLGFIIDFILVFILVFTFNKLELSYFIGIIGFLLYESILYIHT
                     HKKAKKLKSEIYAKLGHIDIDSKLIVDMDFINKKNKIIKKFKIIYLIPILFTLGMSIF
                     IAFNYNQLPDSIATHWNINGSPDVFIDKSFLNVFKLIGTDFCLMVLLYITSIGSIKSR
                     IKIDTNRIEESRVENIKYLNKIGYLFLILMIIMTTQFFTTLLSIKTKLLTAMNITTLL
                     VIIYLIATYINSPNLKFNSSYSPEEDEKYWIAGIMYNNPNDPSLMVNKRFGIGWTINF
                     GNPLGKILYIAIALLLIFSLFSLIKSLLL"
     gene            complement(20507..20896)
                     /locus_tag="KNP36_002103"
     CDS             complement(20507..20896)
                     /locus_tag="KNP36_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0873976.1"
                     /translation="MVLNLDFNSDKSIYVQIKEEITKAIASGELKINESLPSVRSMAE
                     NIGVNLHTVNKSYNELKEEGFLNIDRRKGAIVAQLPMKIDNTTRQKNKLDLELLVAKS
                     YLSGISKEEFLSLSSSLFDKYEVKYYE"
     gene            21088..21534
                     /locus_tag="KNP36_002104"
     CDS             21088..21534
                     /locus_tag="KNP36_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873977.1"
                     /translation="MLTYLMKRQMHKKDDGMSKPMMITGAVITGVGAYAVYKMVKSHK
                     SNSQMVNTNYYGNSDYDDYKYDEFDYDCDCRDTKQDYEYEELKKKVKEFNSRRINCEN
                     CPHVSQEEMMQYVNSVKDVKEELDLHEDAKKDNIYKEDEYKKYEEE"
     gene            21798..22523
                     /locus_tag="KNP36_002105"
     CDS             21798..22523
                     /locus_tag="KNP36_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0873978.1"
                     /translation="MKRKEIVMLKLLIVEDDSTISFGIKYALEQEGFSIDISKDLSSG
                     KEMISSNEYSMILLDVTLPDGTGYELCQYIRGFSQVPIIFLTACDEEVNIVMGLDIGG
                     DDYITKPFRIRELISRIKAVLRRKGNTSEENKKILKFGDLSIYTLEARVYKNDKEIFL
                     TSVEYKLLLILIQNKNTVLSRTQILEKLWDVTYDFVNDNTLTVYIKRLREKIGDDLCE
                     PIYIETVRGIGYKWIGSENSVSI"
     gene            22510..23754
                     /locus_tag="KNP36_002106"
     CDS             22510..23754
                     /locus_tag="KNP36_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0873979.1"
                     /translation="MFLYNPEVKKFLSKYVTLMFIVIIISIGFSIINVSLTKEMVVRN
                     NQAIIGTLSSKYPNLESQIVDIITQGKSMENIDYGQKILIKYNYDKSIRINSEPIISK
                     LVLETIKINIILVCIIFILIFVLIVRYFTSIYNDLSDMTKYVYYSSEGKPFDMKNKNQ
                     EGQIGLLKTELLKMTTILNEKVELLKREKIFLNNTISDISHQLKTPMTSLIMLNDLLY
                     NDVPYEVKIDFLNKIKNQLNRMDWLIKSMLKLSKVEAKVINFKKDKVKFSELIHRAML
                     SMKIPMEIKNQKLTIEGNDNVSYIGDIDWSVEALVNIIKNCVEHTPEFGNIIITYKEN
                     PLFSELIIKDEGEGIDKKDIPHVFKRFYRGRSSSKEDSVGIGLAMSKSIIESQNGDIY
                     VNSEKGKGTEFHIIFHKMYDSD"
     gene            23834..24511
                     /locus_tag="KNP36_002107"
     CDS             23834..24511
                     /locus_tag="KNP36_002107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0873980.1"
                     /translation="MEILRVENLTKSYGKNETKVDAIKNVSLSVEKGTFIAITGPSGS
                     GKSTLLHLLGGVDRPTSGKVYINDVDIYNLKTKDLAIFRRRNIGLIYQFYNLIPVLNV
                     KENILLPAELDNRDIDREYFDDLMKTLGLIDREKHLPNQVSGGQQQRTSIGRALINRP
                     SIILADEPTGNLDSKNSKEILELLKLSVKKYNQTLIMITHDKNMALQADRIISIEDGI
                     IKSDEVM"
     gene            24512..>26966
                     /locus_tag="KNP36_002108"
     CDS             24512..>26966
                     /locus_tag="KNP36_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0873981.1"
                     /translation="MNLYTSLTIRYLKQNKRRTIVTIIGIILSTALICGIGNIFESFM
                     DYQMRETIKNDGSFHVTFYDVNRKNVEYVTKSAEIEKHAFTKQLGYSKLENSENAILS
                     IKQYDKNAINGYKVSIKEGRFPAKEGEIVLSESIINLIDDKLKIGDKITLKVGDMFDS
                     SKKKIDSMTFHEGDYIANEKDRTFKVVGIIEKPGFERYNGIATAIAYFNPMNNYNDTI
                     NVSVAVKNPKDVYKISNKISKNIYSNKDKEAVSDMIKYNEHLLRLQGASKYSNINSSI
                     KSIIIAVTILVIVCTIATVYNSFSISINERKKQFGILNSIGATSSQIKRLVFIEGIII
                     SLIGIPIGLISGTVAIDLLFKIINKYFTESVVTKMSLQIVYNPIIIIVSIIIVLLTIF
                     ISILLPAISASNISPLNVIKNTGEYKVGKIKSSRLIKMIFKTEGVLAYKNIRRNRKKF
                     IITLFSLMVSIIIFISFSGFTLLLLRGEEIRNSQRKYDLYLTAKNTARSVEDTISELE
                     DIDGIKNFELATGQYVSIRVSENKINKSKEDLIRKYYQKYKIGDSYEYDFSNNELIFP
                     GDFAVKNKINNLVQGSFNKERAIEENGVILVRKSAIEENGKKGVVELTNYKVGDTVNC
                     EYLDENALSKKVKVKILAITDEERLGLGYQNMGLQFITYDEVAKNLNLKLSKSLIFID
                     SGGSIKTKKEIEALANKNNFNFYDESASNESEKQDLKVIKIFVYGFIVVISLVSVTNI
                     LNTVSTSINLRKRELAVIQSIGVTPKGFRKMIYLESFIYGILSLLFGIPISIGIILIM
                     NKLISGVIEFSPIIPWTAIV"
BASE COUNT        10998 a         2710 c         4759 g         8499 t
ORIGIN      
        1 aatttaaaaa gagattgtgt caaattataa ctttctattt taaagaaaga tatttgcttg
       61 ttgataaaac tacaaatata tgatttgaag caatctcttt aatttttgga ggtggaaaat
      121 gaaagttttc aatcaattgg taataatttt atctatctgg gtaataggag agtatataag
      181 ttcctttata caaggaatta tacttattcc tgggagtata gttggtatgc tattattatt
      241 tctactacta caatttaaag ttttagactt gagtagtata gaaaatgtaa gtggattttt
      301 cctcgataat atggctatat tttttattcc agcaggtgta tcacttataa agtcattaga
      361 cctaataagg gaaaatgtat tagtgctttt attagtcata tgtttaagta cactaatagt
      421 aatgtatact actggaatta ttgtggagaa aatgataaaa aagaaggaag aaggacaaaa
      481 aaatgtataa tgtattacag acaccagtat ttggtataat agtaacaata gtttttttca
      541 atttaggaag atacattcaa cgaaaaacaa gtaatcctat atgtaaccct ttattaattg
      601 caatcgtagg aataatattg tttttaagca tatctaaaat cccttatgag aattacaaga
      661 taggagctga tagtctaaat ttctttttag gtcctgtcac agtagtactt gcagttccac
      721 tttataaaca atttgaatta tttaaaaagc atatgtttga gattattgta ggaataggtt
      781 gtggtatagt gatttctttt gtatctgtat tgataattgg caaaatagct aattcagatg
      841 taagtataat aaattcacta attccaaaat ctataacaac accaatggga atatctttag
      901 caaattcttt aaatggtgta gaatcaataa cagttgtagc cataattttt acaggtattt
      961 ttggtggtat ggttgcttct acagtattca aactggggaa tataaatcat ccagttgcta
     1021 aaggaattgc tcttggaaca tctgcacatg ctttaggaac tacaaaggct tttgaacttg
     1081 gagaaataga aggagctatg agtggtgttt ctattggagt ctctggtaca attacagtaa
     1141 tactaattcc aattataatg aattttatat aaaaaataaa attaagacga gtaacttgaa
     1201 tacttaaaac aaaataaaat aaaaaaaatt taaaataaaa actgaacgaa aaaaatgcaa
     1261 ataatgaaat aaaaaaatca tgtactgaaa ttataaaaag aaaaatttca tttaggaatt
     1321 aattataaag agacaattac taaacttgaa tttgctaaaa taaaataaat tactgcgaaa
     1381 atagatattt agaaaaaaat actataaatt tactatattg caagttaaat aataagcagt
     1441 atcatattat gctagaaaaa gtttcattta aggcataaat gagatgattt gaacgttttt
     1501 aaagattaga atataaaaga ttgcactaga catatatgaa aaagataata taatagatga
     1561 tgtaatagat gacagttcaa gaaattataa aaaaaattta tttgaaatat tatctattac
     1621 atcaggaata atatatgtaa gagtaagctt ttaaaattct aaagatttag aaagattgaa
     1681 gggagaaaga aatgagtgaa gttaagaata ccctacaaaa acatccagtt ttaagatatt
     1741 caacaatgct atttgggatg ttgatgacat ctataggaat aaatgggttc ttaagaccag
     1801 cacatctact tagtggaggt gctacaggta tagcaacatc tataaactat ttgacaaata
     1861 taaatgtagg tttattaaca tttttaatca atattccaat atttatctta gggttcatat
     1921 accttgaaaa agagttttgt atttcaagtt tggtaaatat gattgtattt tcattattat
     1981 taggagcaac tcaggaaata agtaatatta tacctataca tgatatattg cttcaaagtg
     2041 tatatggtgg tatattatct ggtttaggag tcggagttgt atttagaact aggtcttctc
     2101 aaggtggtac agatataata gctgcaatac taaaaattaa gaagaatata gaaatgaaag
     2161 acactgcttt agcaataaat ggcttgatag tacttacagg aagtttttta tttgggttgg
     2221 atttagcatt atacactctt ataggtctat ttctaaatgc gtattcaatg agttttatta
     2281 aagatgcaat gaattaccaa aaatctgtta tggtaatgtc aaatgaagtc gatttaatag
     2341 cagaagatat aatgaagagt ttagttagag gtgtaacttt tttagatgca gaaggtgcat
     2401 acactcatca aaaaaagaag attatatata caatagtttc atcaaatgag ataccaaaga
     2461 taaaagatat agctttgaag tatgataaaa aggcctttat atctgtaaat gatgttacag
     2521 aagtaaaagg aagagggttt aaagcaaaag atttatagaa aattttacaa gctgggagtt
     2581 tataatgtaa atttgtatat tatatctctc agcttattta aatttagtat acgaaaataa
     2641 aggttttatt aatgatttgt gtatcacttt aaaagatatc attttaaaat taaaattgaa
     2701 aaaattactt aatatgtaga aaacatgacc actattagga tataataaat ttaatagatt
     2761 tagtaaaata tctaggaata acgttggagg aatggcatta tgaatttatc taaagaatat
     2821 gttaatttgt atgataatta tttgaaatat ataaatgaag taaacaaaga gattagaagt
     2881 ataaagaaca tgaagaaacg tgttttaaaa aggggcgatt ttgctccaga aaatgaagta
     2941 ttagaattgg aaggaaaaac aatacgcgat atagatgatg tcgatacaaa aaaaccaaaa
     3001 aataaaatct ataaattttc aaatggggat gtatatgtag ggaaattctt agagggaaag
     3061 atggagggga aaggctcata tacttttttt gtagatgaag gaacagttat ggagtacata
     3121 ggagaattta aagaagataa aaaaaatgga aaaggaaact ttatattttc aaatggaaat
     3181 gaatatatag gttattttga ggaagatatg atgagcggta ttggaaatat gttatatagt
     3241 agtaaagatg aatatattgg aacttggaaa aacggaaaaa aagatggaaa aggtatttat
     3301 aagtggagtg atggatgtat atatgcaggt gaatttaaag gtggaaagat ggaagggtac
     3361 ggtatttgct ataatagtaa aggggaagta ctttatgaag gagaatggaa gaataatttg
     3421 attcatggta agggaactta tatatgggaa aaaggtaaaa agtatatagg tgaatttatg
     3481 catggtaaaa aacatgggca aggaactttt tatctaaata atgaattggt ttatgaaggg
     3541 acttggaaat ttgataagcc atctatattt gatagaacat tagatgaaat attttccttg
     3601 agactgtagc tttatctaat tagtagataa agcttttttc taatacttac tgtaaatagg
     3661 tatgaatgat attgattagt atacactatc aatattaact taataaatgc aatattaaaa
     3721 aattttgatt gattttaaga aggagagata tattgaagag attaattgct ttagtgttag
     3781 tagtacttat tgttttattt tatagtcctg aattattaaa agaaggatat gatttaaaag
     3841 aaaagttttt tcaaagtgaa atatggaatg aatttttaga caaaataaat ataaatgata
     3901 attctaagaa agataaaaaa gaaaaaagtc aaaatttaca atcaaataat actgaagggg
     3961 agaacttagg agagtcagat ataaagaatt ttgaaaaaat aagcttagga gataatttaa
     4021 gctatgtttt atcaagtatc ggcaaacctg gtagaattga tattagtgaa tatggttttg
     4081 attggtatgt atataatcaa tatggaaaag aatttgcaat ggttggactt gaaaatgatg
     4141 aagtagtagc actttatagt aattctatta attcatgtga aaatcaagat ataaaactaa
     4201 atcaagatag acaaacagtg agaactaaga ttacaccatt aaaatataag agaaaaggaa
     4261 ataccagata tataataaac tcagaaaatc aatatgatat aataagtaag gaaggtaagt
     4321 atattacaat tttctacgat attcatgaag aaaatagagt ttgttcatat ttaataattg
     4381 ataaaagcac tgaagatgag tttaaaaatt tatatccaga tgatagcgaa gaacttaaaa
     4441 aatgttttga acttgaagtt atagaccttg taaatagtgt tagaaatcaa agagggttaa
     4501 actcattgag atacagtgaa caggcaactt tgagttcaag aaaacatagt gaagatatga
     4561 gagataataa tttttttgac catgtaaata agaagaatga aactccattt gacagaatga
     4621 aaagagaagg tatagtatat acttcagctg gagaaaacat agcagcagga cagattaatg
     4681 caatatatgc gcatgaagct tggatgaact ctgaaggaca tagaaaaaat attttgggga
     4741 actataataa tattggagtt ggagtaatat ttggaggaag ctataaaaca tattacactc
     4801 aaaattttta taaataacta aaatatttga aaggaagtta aaaaatgaca tcatggaaaa
     4861 aaaagacagt atataagtgc ttaatagcag tagtcttgtt ttgtggaata gtgttaatat
     4921 ctaattttag taaagtttct gctttgatga tggatactaa tggaaatgtt ttgattaaac
     4981 atggttcaag ggaaaaaaag ctaatagcaa ttacctttga tgatggtcct catcctaaag
     5041 aaactagtca agttttagat gtattaaaga aatacaatgt aaaagctact ttttttatag
     5101 ctggaaaaca tgcaaaatgg tataaagaac cattagtaag agcaagtaaa gaaggtcacg
     5161 agataggaaa tcatactttc aatcatcctg atataagtaa tttaagttct agtcagatag
     5221 aagaggagat tgttaagtgt gaagacattt tgaaagaagt aactggaaaa aaaccgacat
     5281 tatttagacc accatttgga agttatagag aaaaagaatt aatagaaatt gcaaaaaagc
     5341 atgactataa agttgtttta tggacaggtg tagatgtgaa agattggaaa aatccaggag
     5401 ctaatagcat tgcagataaa ataattaata aagtacaaaa tggagatata atacttttgc
     5461 atgattatgc aactaatgat acagttgaag ctttagatat gtttattcca aaaatgattg
     5521 aaaaaggttt taaatttgta acagtttctg agttaataaa ataattttta ggggggagat
     5581 ttacagtatg attcttatga tagacaatta tgattctttt gtatacaacc tagtccaata
     5641 tatagaagaa ttaggggaaa cagttgtagt aaaaagaaat aatgaaatca aaataagtga
     5701 cattgaagaa ctaaatccag aggtaattgt gttatctcca ggaccgtgtt ctccaaaaga
     5761 agctggtatt tgcatagata ttgttgagca ttttaagggg aaaaaaccta tactaggaat
     5821 ttgtttaggt caccaaacta ttggacatgt ttttggagga gatattataa aagcacaaca
     5881 gcctgtgcat ggaaaagtat atagtatcaa ccatactaat aaaggagttt ttaggggact
     5941 taaaaatcct ttaaatgtca ctaggtatca ttcactaata gttgactcca atacagttcc
     6001 aaaagaatta gaaattacag caattactga taaaggggaa ataatgggga ttaggcataa
     6061 gaaatattta atagaaggag tacagtttca tccagaagct attttgtcag agtatggtca
     6121 tgaaatgctt aaaaatttta taacagaagc tagagaaagg gtacatatgt aatatgataa
     6181 gagagataaa tactaaatta aattcttttg agatatttac tatttttaga aatgaacatg
     6241 acagttttat attagacagt gctatggaca aagaaaaatt gggaagatat tcttttataa
     6301 gtagccaacc atttaaggta ttaaagtata aagatactga tgaaaatcct ttagaagttt
     6361 taaaagaaga actacataag tatagggttg taaatgatac taatcttcca tttgtaggag
     6421 gtgctgtggg atatttatct tatgatttag gtaattacat agaaaattta cctagaactg
     6481 ctgtagatga tattgagatg cctgatatgt attttggatt ttataatcat gtaatagtta
     6541 tagaccatct tgtgcaaaaa acttatatag ctactccaaa catagatatc gaattagaag
     6601 aaaagataat agatgatata gaacaaagaa tattaaaaga agagaaaaaa ggtatagata
     6661 gcatatgtta tgaagaaaaa gaagtaacac ctataagact taaatctaat tttacaaagg
     6721 aagaatttaa aaatgcagtt caaagtgtta gagagtacat aagacaagga gatatatatc
     6781 aagctaattt aacacaaagg ttcagtggag aaacagaact tacaagcttt gaattgtata
     6841 gggacttaag aagatttagc ccagcaccat ttggggcatt cttaaacttt gaagatgcac
     6901 atatattatc aaattctcca gaaagattta taagatgtgt taataagaga atagaaacta
     6961 gaccaataaa aggtactcgt ccaagaggga aagataaaga agaagattta agacttcaac
     7021 aagaacttag aaatagtgaa aaagatagag ctgaactact tatgatagta gatttagaaa
     7081 gaaatgatat tgggagaata tctaaaactg gaagtgttaa agttccagag ctatttgtaa
     7141 ttgaaccata tgcaaatgta aatcacttag tttccacagt tgtaggtgag ttaaaagatg
     7201 ataaagatgc tactgatgta ataaaagcaa cttttccagg ggggtctata acaggagcac
     7261 ctaagattag agcaatggaa attatagacg aattagagcc aacgcaaaga aatgtatata
     7321 ctggttcaat aggttatata ggttttaatg gtgatatgga ttttaatata gcaattagaa
     7381 caataatcaa aaatgacaaa aaagtctatt ttcaagttgg aggaggaatg acttgggatt
     7441 ctgacccaga tgaagaatat caagaaacac ttgataaagc taaatccata atgaaggctt
     7501 tgaggggata ttatgaagaa taatgtaggt tttgatagta gtttaagtaa atttggaatt
     7561 ggtttgtttg aaactattag agttaaaaat ggaatagcag tagatttaga tatccatata
     7621 gaaagaatgc taagttcaat aaattgtttg gatttagata taaaatataa aaaagatttc
     7681 ttgataaatg aaattgttac atatataaaa aaagaaaatg tcattaataa agcacttaga
     7741 attactgttt ttgatgaagg ttataatata tctattaggg atattccata taatcaagag
     7801 acgtatgaga aggggtttaa attagctata tctccaatag ttagggggaa tagtttaatt
     7861 catagacata agactactaa ttattttgaa aacatatata ccaaaaatat cgcaaataag
     7921 actggttata atgatggtat atttttaaat tcagaaggtg taatattaga atgttctatg
     7981 agcaatattt tctttgtaaa aggagaaaga gtgtacactc ctagtgatag attaccgata
     8041 ttaaatggaa taataaaaaa aaggattata gagatttgtg acgaattaca tatagagttg
     8101 atagaaaatg aaattaatat atcagaaatt agtagttttg attttgtttt tgtcacaaat
     8161 agtcttatgg gcgctataaa ggttacagaa attgacaaaa taaaatttaa taaagaaaat
     8221 gttgtttttg ataaaatagt gaagttatta gaataaatta aaatattaac aatttgttgg
     8281 agacaaaaga tgataggttg tatttatgaa gtatacaatg aagagataac taaaataata
     8341 gaaaaccaaa acactttggc tgtatattta gtgggttcta gtaaagacgt agattttact
     8401 ctttatgatg tagagataaa cgatattgat gtgttcgttt ttgtaaaaga aggggaaaaa
     8461 caagagagaa tactgtttaa aaaaaaggga atagaatttg atgtaaatta cttttcaaaa
     8521 gatggtgtaa aaaaattatt atcaaatagg gaatatttct ttgtgaaaga aatgaaagat
     8581 gctaaagtac tgtttgatag ggagaatata tcacatatta taaaagatat aagtagaaat
     8641 atttacttag aaggacccag taaaatgtca ttagaggaaa agtcttttat aaagcaagat
     8701 attggagcaa aaatatcgaa tttaaaaaat aaagaaaaat ttgatgtttt tgaatatcat
     8761 tttttgacga atttatattt aaaagatata ataattgggt actttaatat aaatgataaa
     8821 tgggtaccaa aagacaaaaa attgctaaaa gttttaaaaa aagaaaataa tgagcttttt
     8881 gaactagtgt caaaagtaag tgaaaattat gactatcaaa gacttttaga tgtttataat
     8941 tatattttta aagaaattga gacaaaagag gttataaaac taatcttcta gtcacaaatc
     9001 aatgggggga gtttaaatga ataaagttga taaagaaaag atacaacatg cagtaagaga
     9061 aatactagag gcaattgggg aagacccaga tagagaaggt ctaatcgaaa ctccaaatag
     9121 agttgctagg atgtatgaag agatattctc tggtcttagt gaagaaccaa gagaccattt
     9181 aaaagttctt tttgcagatg aaaaacatga agagttagta ttggtaaaag atattccatt
     9241 ttattcatgt tgtgagcatc atctagttcc tttctttgga aaagctcata ttgcttattt
     9301 accaaaagga ggaagactta cagggctttc taaacttgct agagtaatag atacattggc
     9361 aaaaagacca caattacaag aaagaatcac taaaaatgct gcagatataa taatggaaga
     9421 attacaacct tatggtgtct tagtagtagt agaagctgaa catatgtgca tgacaatgag
     9481 aggcgtaaaa aaaccaggtt caaaaactgt tacatcagca gtgagaggaa tatttgaaaa
     9541 ggacattgcg tctagagccg aggctatgag tttgattact atgaagtagc aatttattat
     9601 agatataatc atttattgag ataaaattta atttaaggga gtgtcattaa ttgtgtttga
     9661 ttatggtaaa agaacttata taatgggaat attaaatgta actccagata gtttttctga
     9721 tggaggagat tttaataact tggacatagc aatacaacat gcaaaagata tggttgacca
     9781 aggtgcagat ataatagacc taggaggaga gtctacacgc ccaggtcata gctatgtaga
     9841 ctcagacgaa gagctaagaa gagtaatccc tgtaataaaa aaacttaaac aggaattgga
     9901 tataccaata tcaatagaca cttataaggc agatgttgca gaagaagcat taaaattagg
     9961 tgtcactatg gtaaatgatg tttggggtct tagaaaagat aaaaatatgg cttctgtaat
    10021 aggaaaatat gatgcagaag tgtgtataat gcataatcaa gatgggacaa actatgacaa
    10081 agatataatg gagtcaataa aagacttttt taaggtaagt atagaaatgg caatgagttg
    10141 tggtgtaaaa aaagaaaaaa tagtacttga cccaggtgta ggatttggca aggattttga
    10201 acaaaatatt gaagtattga gaagattaaa tgaattaaaa gatttagggt atcctatttt
    10261 gcttgggaca tccagaaaat cagtaatagg aaaagtactt ccagttgagc ctaaaaaaag
    10321 attagaaggt acaatagcta ctactgttct tggtataaga gatggcgtag atatagttag
    10381 agtacatgat gtttatgaaa atttaatggc agctagaatg actgatgcaa tatatagaaa
    10441 gtaggtataa tataatggat aaaatattac ttagtaatct aggattctat ggatatcatg
    10501 gtgttcttaa agaagaaaat tttctaggtc agaaattctt tgtcgacatg gaactttata
    10561 ttgattcaag agaagcaggt cttagtgacg atataaataa atctgtaagc tatgccgagg
    10621 tttacaatgt tgttaaagat attactgaaa ataaacaatt taatcttttg gaggctttag
    10681 cggaaaatat tgctgaagaa gtcttgaata aatttatact tataaatgga gttatggtca
    10741 gagttagaaa gcctgaggct cctgtaaatg gtatttatga ctattttggt gttgagataa
    10801 ggagaacaag agatgaataa ggcttatttg ggaataggta ctaacatggg tgatagattt
    10861 gataatttat caagagcatg tgaacttttg aaaaatagtg attctatata taaagtaaaa
    10921 gaatcaagct tatacgaaac aaaaccatgg ggatatacag aacaagcaga ttttctaaat
    10981 atgtgtgtag aaatagaaac agagtttgaa ccttatgagt tgttagaata ttgtcaagaa
    11041 atagagagag aactacacag agagagaata gttcattggg gaccaagaac tatagatgta
    11101 gacgtactat tttttaatga tgtagtttcc actgatgaaa gactaacaat acctcatcca
    11161 aggattcaag atagagcttt cgttttgata ccacttatgg atttaaatga agaacttata
    11221 ataaatgaaa aaacaataaa agaacattta aacctcctat ctgctgaaga aagagaagaa
    11281 gtaaaggagc ttgtaggtta tgaaagaaaa cctatttaat aataattcaa agatagagat
    11341 aaatacaaat aacaaaaaga taactgtaaa aaaagataaa cttataatag ctggaccatg
    11401 cgcaatagag agttatgagc aacttttgga gactgctaaa tttgtaaaaa gtcaaggagc
    11461 aaacatttta agaggtggag catacaagcc aagaacatcg ccaaattcat ttcaaggatt
    11521 aaaaaaagaa ggtcttgaaa tattaaaagc agttaaagac gaagttggta tggctgttat
    11581 tacagaactt atggatgtaa gagatatgga cgaactgtat agtataagtg atataattca
    11641 aattgggtca agaaatatgc aaaactttac tcttttaagt gaagtgggaa aacaaaataa
    11701 acctgttatg ttaaaaagag gaatagcatc cacaattact gaatggatag gtgcttctga
    11761 atatatagca atagaaggaa atagtaatat tataatgtgt gagagaggta taagaacgta
    11821 taatgattat actagaaata cattagattt agctgcggta cccattattc aaaaggaaac
    11881 aggtcttcct gttgtggtag acccaagcca tgccactgga gttagatatt tggtaaaacc
    11941 tatgtcactg gcatcttttg catgtggagc agatggaata atggtagaag tacatcctga
    12001 cccagaaaat gctttgtcag atggtgctca atctctttgc tttaatgaat ttgaagattt
    12061 aatgaaatca attaataatt attaaaagag gcaagagcct cttttttatt cgtaatcgtt
    12121 gctaaggtaa atttataagt tataatttga tagttagatt atttaatata aataaagatt
    12181 taatattgat agaattaata taaaaaataa aaattttttg attaataaga aggatatcaa
    12241 taaaaaaagt cgaattgtgt atattgagtg attgacaaat ttagaatata gtgtagaata
    12301 gaaatgttaa cacaaaaaat tacaccagaa ggtgataata tgaatgatat aaaagacatt
    12361 attgaagaaa taaaagctag atgcgatata gcaagtataa tatctgaata tatgaatata
    12421 aaacaatctg gagctaatta caaaggatta tgtccatttc atggcgaaaa gacaccttct
    12481 ttttatataa atacatcaaa acagatttat aagtgttttg gttgtggtga aggtggagac
    12541 gtaataaatt ttgtcatgaa aatggaaaat ttggatttta tggatgctgt aaaaatttta
    12601 gcaaataaat gcggtataga aattaacact aacatgaatg aagaaactag gattaaaata
    12661 gaaaaatcta agaaatttca agatattcat acggaagcag ctagatttta tctttcaaac
    12721 ttattgggaa gcaaaaatct tgggtatgaa tatttaagaa taagaggact agatgataaa
    12781 attattaaga aatttggttt aggattttct ttggattcat ggaattcact tatgaatact
    12841 ctaatcagta aaggatataa aaaacaagac ttattagagt gcggtctaat tgcaaaaaat
    12901 agagatggaa ctaattgcta tgataaattt agaaatagag ttatgtttcc tatattcgat
    12961 tatagaggaa atataatagg atttggggga agagtattag acgattcttt gccaaaatac
    13021 ttaaattctc cagacacatt aatttttaat aaaaaacaga acttatacgg attaaatttt
    13081 gctagaaaaa atttagaaag taaaactata gtcttagttg aaggatatat ggatttaatt
    13141 tcactttatc agtatggtat aaaaaatgta gtagcaaccc ttggaacagc cttgactgaa
    13201 caacaaggca ttttaataaa gagatatgcg gacactgcta ttatatctta tgattctgat
    13261 gaagcaggaa taaaagcgac tttaagagct atagatatac ttactaaatt aggtatcaat
    13321 gtaaaagtgt tagacttaaa agatgctaaa gacccagatg aatttgtaag aaaatacgga
    13381 cttagtgatt ataaaaaagc tatggatgtt tctactcact acataaaata taaaatagat
    13441 catcttaaaa aagaatttaa cattcaaaaa gatgaagaac gagtgaagtt cgcaaaagaa
    13501 gcttctaaaa ttataaaaca attgacaagt cctgttgaaa ttgattttta tacaaagtat
    13561 ttaagcaatc aaatagatat taatgtcgag tctataaaga gagaagttta tggtaaaaat
    13621 tacaataagc catataataa caaaaatcaa aagaaaatag aagaaaaagt aattgaaaaa
    13681 gtcgaagtca gacaagacgg aaaacaatta gttgaagaaa ctctaataaa aataatgtta
    13741 gaagacaaaa aaattagaga aatagcgtta cttaaagtag aagaaagtga ttttttattg
    13801 aaagaaagta aagaaatttt aaattacatg attaaaaatc aagaattgga caaaataact
    13861 attgacaaat tgaaaagttt aaacatatcc gaagaatact taaaagaatt aaattcaatt
    13921 tctttgaata gtataaactt agagaacaca aaagaaatag aaggaataat aacaaatatc
    13981 agaaaaaact cattagaaga gcaaattaat agcttgttga gagaacaaca agaattagaa
    14041 aataataatg atatgaaaga ggtagatggt agagttatgg aaattgcttt aaaaatagtt
    14101 gagataaata aaattttaaa gagcttgtag agaaaggagg tttgagtgtg gaaaataaat
    14161 cgaataaaaa agagttaaaa aaggttactg ctaagacatt aatagaaaaa ggaaaaaagc
    14221 aaggttctct gacacttgca gagataatgg aagctttttc ggagactgaa cttgataagg
    14281 atcaagtaga aaatctttat gagactttag gaaatttggg aatagaaata acagaaacaa
    14341 aaaactataa agctgatata gatttttcgg ttgctgatga cgatttaagt ataggccact
    14401 tagatgaaga tgcagaggca atttcacatg atgactcttc tgcaatagaa atagaaactg
    14461 tggatttatc tttaccaaaa gggataagta tagatgaccc tgtaagaatg tacttaaaag
    14521 aaataggaaa aattcctcta cttaaaccac atgaagaagt agaatttgct agaaggatgc
    14581 acgaaggtga tgagatagca aaacaaaggt tagttgaagc aaacttaaga ctagttgtaa
    14641 gtatagcaaa aagatatgta ggaagaggta tgcttttctt ggatttaata caagagggaa
    14701 atttaggtct tataaaagca gtcgaaaaat ttgactatac aaaaggatat aagtttagta
    14761 cttatgcaac atggtggata agacaagcta taacacgtgc tattgcagac caagctagaa
    14821 ctataagaat accagttcat atggtagaga ctataaataa gctaataaga gtatcaagac
    14881 aactacttca agaacttgga agagatccaa aaccagaaga aattgcaaaa gaaatggaaa
    14941 tgacagaaga taaagtaaga gaaataatga aaatagctca agaccctgtg tctttagaaa
    15001 caccaatagg agaagaagaa gatagccatt taggtgactt tattccagat gatgatgctc
    15061 cagccccagc agaggcagca gcatattctt tattaaaaga acaaatagaa gatgtacttg
    15121 gttcattaaa tgatagagaa caaaaagtat taaagcttag atttggtctt gaggatggta
    15181 gagccagaac tcttgaggaa gttggaaaag agtttgatgt aactagagag agaataagac
    15241 agatagaagc aaaagcacta agaaaactaa gacatccaag tagatcaaaa aaacttagag
    15301 attatttaga ctaaaaagat acatcattga tgtttttgtg ataaatgcca tgagataagt
    15361 gatatctcat ggctattttg tagtaaagat ttaattttat ttttgtagtt atttcagtct
    15421 aatatctata acttggatta aatcctataa ataaagggaa ttgaaaggag aattatattt
    15481 gaaattaaca gatagattat tgaaaatagc atcattagtg tcagatggta aaaaaatagc
    15541 tgatatagga acggaccacg gatacatacc agtatatttg ttaaaagagg gaaaagtacc
    15601 atttgcagtg ctagcggatg ttaataaagg acctcttgac aatgcacata aagaagtcat
    15661 acagaacaat cttttagata aagttgattt acgattgggt tctggtatag agatacttga
    15721 aataggggaa gtagaagaag tgataattgc tggtatgggt ggaatcttga taagtgagct
    15781 tctcgaagct aaaaaagaag tagcacataa tgtagaaaaa ttaatattac agccaatgca
    15841 agcacaagaa gaacttagat attacctttt aaacaacgga tatgaaattt tagaagaagt
    15901 tttagtgaga gaagatttta gaatatatga gataattgtt gccaaatata caggtaaaaa
    15961 tactataata gaagatgaga tatattatga ggttggaata aagcttttag aaaacaaaga
    16021 ttctcttttt aatgatttta tagaaaaaaa gataaagaca tatagttcta tagttaataa
    16081 attagaaggg aaaaatgggg aagctataga taagaagaga aaggaaagcg aagttgcaat
    16141 aaaaaaactt gaaaatttaa taaaataaat aggaggtata tatgctatta aagagtctaa
    16201 ctagaaaaat tgaaaaaaag tatcctctaa acttagcaga ggattgggat aatgtaggtc
    16261 ttatagttgg agattttgat atggatgtaa aaaaggtatt ggtatcttta gaagctaatg
    16321 aagatgttat tgatgaagct atatccaaaa atatagattt aattgtgaca catcatcctt
    16381 ttatatttgg gaaaattaat aaaattaata gtggagattt aaaaggcaga cttatccaaa
    16441 aacttattaa aaatgatata tcactttatt ctatgcatac gaattttgat atagcatttg
    16501 atggtctaaa tgactatttt atggaaatta tggaatttgg taattcaaag gttttagata
    16561 taactaaaag cgaaaatttg tataaattag cagtatacgt tccacataac tattcagatg
    16621 aacttagaaa ggttttaagt aattcaggag caggtcatat agggaattat agtgattgta
    16681 cgttttcaac agaaggtgaa ggacaattta agccattaga aggctctaat ccgtttcttg
    16741 gaagtgtaaa tgatatagaa actgtaaatg aagttaaaat tgaaactgta gtaccacaga
    16801 agcttttagg tggggtaata agttctatgt tagatgcaca tccttatgaa gaagttgcat
    16861 atgatttgta caagttagaa aataaaggtg agatatttgg actaggtaga ataagtaaac
    16921 ttgataaaag tatgacatta gaaagtcttt caaggaaaat aaaagagaaa ttaaatatga
    16981 aacacataag agtagttgga aaccttagta cagacataac gaaagtagcc gttgtaacag
    17041 gagctggttc agaatttgta aaaaaagcta agagacaagg tgcagaagta ctaattacgg
    17101 gtgatgtaaa gtatcatgag gcacaagatg cacttgatat tggaatgtgt atagtggatt
    17161 gtggtcattt tgatacagaa gatatattca aaaatgttat gaagagattt ttagatgaat
    17221 ttagtgaaat tgaagtaata aagagtaatg tatatttgaa tccatttagt actatttagc
    17281 agtgtttgat aataaaaata ctatataaaa aataaatttg agtttaatta gggggataat
    17341 gatgaaagta gcagtaattt ttcatagtgt ttgtgggagt acatatttat tagctagaga
    17401 atataaagaa gcgcttgaag aaatgaatat cgaggtagat atatttagag taagtgacga
    17461 agttgcaaaa acacttcctc aatattattt gataaattcc aaagaataca aagacgaatt
    17521 tgaaagtata aatgtaatta aatctggaaa agaaatatta gattatgatg ctatatttat
    17581 gggttcacca acatattatg gaaatgtatc tggaccaatg aagatgttta tggatagttt
    17641 ttctgatatt tgggtaggtg ctcctttgag tggtaaaata tttggttgtt ttgctacagc
    17701 aggttcacaa catggaggag gagaattagc tttgcaagct atgaatatat ttgcccaaca
    17761 tatgggaatg actcttttgt cagttccatg ttcagtaaga ggaggttatc cagcgtatgg
    17821 aatacttcat atagcaggag ataattctga tataaggcca aatgatgatg ccaagatagg
    17881 tataagagat tacctaaaaa gacttaacat ataagaatat catataaaaa tacctaaaag
    17941 cgactgtata tacttttagg tatttttact taattataaa cgtgaagctt taccagaaat
    18001 atggtcaatt tctattttaa caacagttgt taagttcata tccttctcta tgtacttcat
    18061 gccttcttca aagaatcctt tagaatattt ttttattatt tctacaagag catttttctt
    18121 ttcttcattt tctacagtgc aagcttttcc aaaaactata gcactagaat aagtagtact
    18181 aaatttatct ggaataacac tttcattagc aactactaaa aaagaaactt tgttgttttt
    18241 cgatatatta tctaacttat gcccatttct tgcacaatga aagtaaatag aatcattaaa
    18301 gtatacataa tttacagcaa ctccataagg ataaccattt tcagatatag tggaaaaagt
    18361 accaaattca ccatttttta atacttcaac agtatcttct tttgtcattt ctcttttttt
    18421 caatctcatt tctttaaaca taatatcatc ctttctaatt ttgatgctta aattaaattt
    18481 tagaacattt ataaagatta tgctatgttt tttacaaatt ttaagaaaaa aatatagttt
    18541 aagataaaag gtagtgaaag agaagctatt tggaggttta tttatgatat tattgttaga
    18601 gtagtacaaa taatactaat aaatttaata gctggtttct tgttatttaa ggtagtaagc
    18661 atgtctataa gaaggggaag ttatcgaggg tagaagttgt tgtttataac gatattataa
    18721 agaaaatatt attatataaa ataataaata gtaaagaggt atcaagttga atataatact
    18781 taatacctct tcaaaattaa gttataaaag tgttgtggga attgtcctat acatggtaag
    18841 gagataataa agaatgtatc tttaaagtct caactaaaca gcaaaattta tccaacaaac
    18901 atacaataaa tgcttctttg tatctaggtg gcttaacagt aagtggccac atgtgtttta
    18961 aaattatgtc cgtttctttt tcatttattt gaaaaaataa agttgcattt tttaatgctt
    19021 ctctagggtg agtaaatcca tgtaatcctt ttctatcacc tttgtaatgc caatcataaa
    19081 gaaaaaagtc gtgtagtaaa gctcctctaa taacactttg aatatcaaca cttaagtgca
    19141 attttttaca taatagataa ctataatatg ctactgacaa actatgttca agacatgaaa
    19201 cattgccatg atgaggaaat gttctcataa gttgaacttt ttcagaagaa agtatctcag
    19261 aagcacattc attaaaatat ttgatttcag cttttgacaa cattatgaaa atctccattc
    19321 ttagtaatat ataaatacta tacttcaacg ataatatgaa atatttctta tcctacaaaa
    19381 tataataccc aataatacaa gtaagatacc ttttatggta ttttaaagta agagagattt
    19441 tattaggcta aacaatgaaa aaattaaaag taaagctata gcaatatata gtatttttcc
    19501 aagaggattg ccaaaattta tagtccatcc aataccaaac cttttattaa ccattaatga
    19561 tgggtcattt ggattattat acatgatgcc tgctatccaa tacttctcat cttcttctgg
    19621 agaataagat gagttgaatt ttaaatttgg ggaattaata tatgttgcta ttaaataaat
    19681 tataactaaa agcgttgtaa tattcatagc agttaatagt tttgttttta ttgataaaag
    19741 agtagtaaaa aactgtgttg tcattataat catcaatatt aaaaacaaat aaccaatttt
    19801 atttaaatat ttaatgtttt caactctact ttcttcaatt ctatttgtat ctatcttaat
    19861 ccttgacttt atggatccaa tggaagttat atataataaa accattaaac aaaagtcagt
    19921 accgattaat ttaaatacat taagaaatga tttatctata aaaacatcag gagacccatt
    19981 tatgttccaa tgagtggcaa ttgagtctgg caattgatta taattaaatg ctataaaaat
    20041 actcattccc aaagtaaata gtatcggtat taaatagatt attttaaatt tttttattat
    20101 tttatttttc ttatttataa aatccatatc tactattaat tttgaatcta tatctatatg
    20161 acctaattta gcataaattt ctgatttaag cttcttagct tttttatgtg tatgaatata
    20221 tagtatactt tcatataata aaaaacctat aataccaata aaataggaaa gttccaattt
    20281 attaaatgta aagaccagaa taaaaactaa tataaagtct ataataaaac ctaaagataa
    20341 tagtttttta aattctttat ctaactttat aaagtaatta taatttttat gctcttggtc
    20401 tatagaaact ccatagatgt gttttttacc tacaaaatag ggtataaaat aaaatgtagc
    20461 atacatcaaa attagaactg gaaatattgt aaatagacat tcaatcttac tcataatatt
    20521 tcacctcata cttgtcaaat aaacttgaac ttagtgacaa aaattcttct ttactaatac
    20581 ctgataaata agattttgcc accaataatt ccaagtcaag tttatttttt tgacgagttg
    20641 tattatctat tttcattggt agttgagcta caatagcacc ttttcttcta tcaatattta
    20701 agaatccctc ttcttttaat tcattgtagg atttgttcac tgtatgtaaa tttacaccaa
    20761 tattttcagc catacttctt acagatggaa gtgattcatt tattttcaat tctcctgaag
    20821 ctatagcctt agttatttct tctttaattt gtacataaat agatttatca ctattaaaat
    20881 ctaaatttaa aaccataaaa aacctccatt atgctttata aatgaaaacg attgttatat
    20941 acatagtata acataaaaaa taataacaaa cacaaaatat aagtttatat tttgtaaaaa
    21001 ttgtaattta aaaaataaca taatttttat taaaataata cagatactat ttatagatag
    21061 aaataaaaat tagaaaggag aaaaaatatg ttaacatatt taatgaaaag acaaatgcat
    21121 aaaaaagatg atggaatgag taaaccaatg atgattacag gagctgtaat tacaggtgta
    21181 ggagcatatg ctgtatataa aatggtaaaa agccataaat ctaattctca aatggtcaat
    21241 acaaattatt atggaaatag cgattatgat gattataaat atgacgaatt tgattatgac
    21301 tgtgattgta gagacacaaa acaagattat gaatatgaag aattaaaaaa aaaagtaaaa
    21361 gaatttaatt caagaagaat aaattgtgaa aattgtccac atgtttctca agaagaaatg
    21421 atgcaatatg taaatagtgt taaagatgta aaggaagagc ttgatttaca tgaagatgct
    21481 aaaaaagata atatttacaa agaagatgaa tacaaaaaat atgaagaaga ataagtaata
    21541 ttttgtataa ctgaacaaat agtaatgtca aattatttaa tatctagttt taatatgtaa
    21601 gttgtaactt aacttgaaag aatcagtatc attctttaga tagttaagta acaacttaca
    21661 ttttattttt ataaatttta atagttcttt gtgactattt tgtaatttta gaaatatttt
    21721 agtatccagg gtaattgtgt ataataaaac ttgtatagat agatagtatg aaattaagca
    21781 gatagtttaa aattaaaatg aaaagaaagg aaatagttat gttaaagttg ttgatagttg
    21841 aagatgatag tactatatct tttggaataa agtatgcttt agaacaagaa ggatttagta
    21901 tagatatatc aaaggattta tctagtggaa aagaaatgat ttcttctaat gaatatagca
    21961 tgatactgtt ggatgttaca ttgccagatg gaactggtta tgagctttgt caatatataa
    22021 gaggattctc tcaggttcct ataatattct tgactgcttg tgatgaagaa gtaaatattg
    22081 taatgggtct cgatataggt ggagatgatt atataacaaa accttttaga attagagaat
    22141 taatatccag aataaaagct gttttaagaa gaaaaggtaa tacttcagaa gaaaataaga
    22201 aaatacttaa atttggagat ttaagtatat atacattaga agctagagta tataaaaatg
    22261 ataaagaaat atttctgaca tcagttgaat ataaacttct tttaattctt atacagaata
    22321 aaaatactgt tttaagtaga actcaaatat tggaaaaact ttgggatgta acttatgatt
    22381 ttgtaaacga caatactcta actgtttata taaaaaggct tagagaaaaa ataggtgatg
    22441 atttatgtga accaatctac atagaaactg taagggggat tggttataaa tggataggaa
    22501 gtgaaaatag tgtttctata taatccagaa gtgaagaagt ttttaagtaa gtatgttact
    22561 ttgatgttta ttgttatcat aatatctatt ggatttagca taatcaacgt gtccttaact
    22621 aaagagatgg ttgtaagaaa taatcaggct ataataggaa ctttatcaag caagtatcca
    22681 aacttagaaa gtcagatagt agacataata actcaaggga agtctatgga gaacatagat
    22741 tatggtcaga aaatattaat taagtataat tatgataaat ctattaggat aaactctgag
    22801 cctattattt ctaaattagt tttagagact atcaaaataa atataatatt agtatgtata
    22861 atatttattt tgatatttgt gttgattgtt agatatttta cgtcaattta caatgattta
    22921 tcagatatga ctaagtatgt ttactatagt tcagagggta agccatttga tatgaaaaac
    22981 aagaatcaag aagggcagat aggtcttcta aaaactgaac tcttaaaaat gacgacaatt
    23041 cttaatgaaa aggttgaact tttaaaaaga gaaaagatat ttttaaacaa tacaatttcc
    23101 gatatatcac atcaattaaa aactcctatg acttctttaa taatgttgaa tgatttatta
    23161 tataatgatg taccatacga agtaaaaatc gattttttaa ataagataaa aaatcaatta
    23221 aatagaatgg attggttgat taaaagcatg cttaaattat caaaggtaga agcaaaagtg
    23281 ataaatttta aaaaagataa ggtaaaattt agtgaactca tacatagagc aatgctatct
    23341 atgaaaatac ctatggagat taaaaatcaa aaactgacta tagagggaaa tgataatgta
    23401 tcttatattg gtgatattga ttggtccgtg gaagcattag tgaatataat caaaaattgt
    23461 gtagaacata ctcctgaatt tggaaatata attataacct ataaagaaaa tccattattt
    23521 tctgaactaa taataaaaga tgagggtgaa ggtatagata aaaaagatat accacatgta
    23581 tttaaacgat tctatagagg aagaagtagt tcaaaagaag atagtgtagg aataggtctt
    23641 gcaatgtcaa aatctataat agaaagccaa aatggcgata tatatgtaaa cagcgaaaaa
    23701 ggtaagggta cagaatttca tataatattt cataaaatgt atgatagtga ctaatctgta
    23761 atatttaatt cactttatag taatagccaa aacctaatat atgaagtata gaatataaat
    23821 attggaggta gttatggaaa ttttaagagt agaaaatcta actaaaagtt atggtaaaaa
    23881 tgaaacaaaa gttgatgcta taaaaaatgt aagtttatca gttgaaaaag gaacgtttat
    23941 agcaataaca ggtccaagtg gaagtggtaa aagtacctta ttacatttat taggaggagt
    24001 tgacagacca actagtggta aggtttatat aaatgatgtt gatatatata atttaaaaac
    24061 taaggatttg gcgatattta gaagaagaaa tataggtctt atatatcaat tttacaactt
    24121 aattccagtc ttaaatgtga aggaaaacat attgcttcca gcagagcttg acaatagaga
    24181 tattgataga gaatattttg atgatttaat gaaaacatta ggtctaattg atagagaaaa
    24241 gcaccttcca aaccaagtat caggaggtca acaacagaga acctctatag gacgtgcatt
    24301 aattaataga ccttctataa tattagcaga tgagccaaca ggtaatttag atagtaaaaa
    24361 ttcaaaggaa atattagaat tgttaaaatt gtcagtaaaa aaatacaacc agacactaat
    24421 aatgataact catgacaaaa atatggcact tcaagctgat agaattataa gcatagaaga
    24481 tggaatcata aaaagtgatg aggtgatgta gatgaattta tatacatcac taactattag
    24541 atacttaaaa caaaataaaa gaagaaccat tgtaaccata atcggtataa tactttcaac
    24601 agctttaatt tgtggtatag gaaatatatt tgaaagtttt atggattatc aaatgagaga
    24661 aactataaag aatgatggaa gtttccatgt tacattttat gatgtaaata gaaaaaatgt
    24721 ggaatatgta acgaaatcag ctgaaataga aaaacatgca tttaccaaac aacttggata
    24781 ttctaaatta gaaaatagtg aaaatgctat attaagtata aagcaatatg ataaaaatgc
    24841 aataaatgga tataaagttt ctataaaaga aggtagattt ccagctaagg aaggagaaat
    24901 tgttttaagt gaaagtatta ttaatcttat agatgataag ttaaaaatag gagataagat
    24961 aactttaaaa gtaggggata tgtttgactc aagcaagaaa aagattgata gtatgacatt
    25021 tcatgaaggt gattatatag caaatgaaaa agatagaact tttaaagttg ttggtataat
    25081 tgaaaaacct gggtttgaac gttataatgg aattgcaaca gctatagcct actttaatcc
    25141 tatgaataat tacaatgata caattaatgt atcagtagca gtaaaaaatc ctaaagatgt
    25201 gtataagata agtaataaaa taagtaaaaa tatatattca aataaagata aagaagcagt
    25261 ttctgatatg ataaaataca atgaacattt attgaggtta caaggtgcta gtaagtattc
    25321 aaatataaat agctctataa agtctataat tatagcagta actattttag taatcgtatg
    25381 tacaattgct acagtgtaca attcctttag tatttctata aatgaacgaa aaaaacagtt
    25441 tgggatatta aattctatag gtgctacatc tagtcaaatt aaaagattag tttttataga
    25501 aggtattata attagtttaa ttggtatacc aataggacta atatctggaa cagtagctat
    25561 agacttattg tttaaaatta taaataagta ttttactgaa tcggttgtta ctaagatgag
    25621 tttgcagata gtgtataatc caataataat tattgttagt ataataatag ttttgcttac
    25681 aatctttata tcaattctac tacctgcaat atcggcttct aatatttctc cccttaatgt
    25741 gattaaaaat actggagagt ataaagtggg caaaatcaaa agctcaagac ttattaaaat
    25801 gatttttaaa actgaaggag tacttgcata taaaaatatt aggagaaata gaaaaaaatt
    25861 tataataact cttttttctt taatggtaag tataataata tttatatctt ttagtggctt
    25921 tacattactt ttactaagag gtgaagaaat tagaaattct caaagaaaat atgatttgta
    25981 tttaactgca aagaacacag ctaggtctgt agaggatact ataagtgaac tagaagatat
    26041 tgatgggata aaaaactttg aattggcaac aggacaatat gtgtctataa gagtaagtga
    26101 aaataaaata aataaatcca aggaagattt aatcaggaaa tattatcaaa aatataagat
    26161 tggagatagt tatgaatatg atttcagtaa taatgaatta atttttccag gagattttgc
    26221 agtaaaaaac aaaataaata acttagtaca gggctctttt aataaagaga gagcaattga
    26281 agaaaatggt gttatattag ttagaaaaag tgcaattgaa gaaaatggga agaaaggtgt
    26341 agtagaactt accaactata aagtaggaga tacagtaaat tgtgaatatc ttgatgaaaa
    26401 tgccttaagt aaaaaagtaa aggtcaagat tcttgctata actgacgaag aacgtctagg
    26461 tcttggttat caaaatatgg ggttacaatt tataacttat gatgaagttg ctaaaaattt
    26521 aaatttaaaa ttaagtaaaa gccttatatt tattgattca ggaggaagca ttaagactaa
    26581 gaaggaaata gaagctttgg caaataaaaa taattttaac ttttatgatg aaagtgcaag
    26641 caatgaaagt gaaaaacaag atttaaaggt tattaaaata tttgtatatg gttttatagt
    26701 agtgatatct ttagtgagtg ttacaaatat tctaaataca gtaagtacaa gtataaatct
    26761 aagaaaaaga gaacttgcag taatacaatc tataggggtt actcctaaag gatttaggaa
    26821 aatgatatat ttagaaagtt ttatatatgg tatactgtca ttgttgtttg gaataccaat
    26881 tagtattggt ataattctaa ttatgaataa acttatttca ggtgtaattg aattttctcc
    26941 gattataccg tggacagcca tagtta
//
LOCUS       DAEHWM010000048        26728 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.049, whole genome shotgun sequence.
ACCESSION   DAEHWM010000048 DAEHWM010000000
VERSION     DAEHWM010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 26728)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26728)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26728
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.049"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            305..1933
                     /gene="aspD"
                     /locus_tag="KNP36_002109"
     CDS             305..1933
                     /gene="aspD"
                     /locus_tag="KNP36_002109"
                     /EC_number="4.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate 4-decarboxylase"
                     /protein_id="HBF0873982.1"
                     /translation="MKNHTYKEIKNIYGKISPFEFKDKLIDIAKYTAKENNRELLDAG
                     RGNPNWTCSTAREAFFTFGHFAITETRSNWDLGHLAGMPQKKGIKERFFKFINENIDM
                     PGAYLARDIINFGINELGFDGDEFVHELADGIIGDNYPLPDRMLPHMEKIVHDYLVQE
                     MKYDISGKYGDVEIFAVEGATAAMCYIFDSLMANELLKKGDTIALMTPIFTPYLEIPN
                     LPRYDFKVVNINANEVDEKGAHTWQYTKKELEKLRDKSIKALFVVNPNNPASIAMDET
                     SCNNLIDVIENYNKDLMIISDDVYGTFVEDFSSLMSKLPYNTVGVYSYSKYFGVTGWR
                     LGTFALHKKNVFDKKINDLTGELKKSVDKRYSDMSLNPSSLSFMERVVADSRLVALNH
                     TAGLSTPQQVQMAFFSAFALIDKVDAYKKLNMSICHRRQKLLFEALELPINENKNNAA
                     YYTQFDIEEWAKLNYGEDLFKFISKTASPVDVLYKLANDYSVVLLSGNGFYGPEWSIR
                     ISLANLYDEAYTKIGKAIREILNGYIVEWQKIKK"
     gene            2054..3049
                     /locus_tag="KNP36_002110"
     CDS             2054..3049
                     /locus_tag="KNP36_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HBF0873983.1"
                     /translation="MSIKKKVAIVFTGGTISMTVDDKVGAAIPTLSGEQILSMVTNID
                     KVADVEVFNFDEIPGPHITPYRMMELKNYVNDLLARKDITGVVITHGTDSLEETAYFL
                     DLTIDNIKPVIVTGAMRSSSELGYDGSSNLSASVCTAVSKDAMGKGVLVVLNNEVLLA
                     SEATKTNTLSLNTFKSLTSGPLGIIDCNELVLTRDIVNRTIIDTDKVESKVALFKAYV
                     GENADFIRFAVDSGYKGIVIEAMGRGNIPPQMLSGVEYAREKGLPVVIVSRCHSGRVF
                     DSYGYFGSGRDLKNLGCIFGGDLPGQKARIKLILALGKTDNLDEIKDFFEKGIYC"
     gene            complement(3227..3610)
                     /locus_tag="KNP36_002111"
                     /pseudo
     CDS             complement(3227..3610)
                     /locus_tag="KNP36_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431032.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
     regulatory      3837..3934
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     repeat_region   4075..4633
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=4075..4104
                     /rpt_unit_seq="aatttacattccatatagttaatataaaac"
     gene            complement(4919..5077)
                     /locus_tag="KNP36_002112"
     CDS             complement(4919..5077)
                     /locus_tag="KNP36_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873984.1"
                     /translation="MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDL
                     KIRFHKTK"
     gene            complement(5371..6741)
                     /locus_tag="KNP36_002113"
     CDS             complement(5371..6741)
                     /locus_tag="KNP36_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp29"
                     /protein_id="HBF0873985.1"
                     /translation="MKLKKLLSLGLVSMFVAGFPISANALDKIDKIQGADKYETAGII
                     ADKQSYTTAILINADSTMADGLSASGLAGATNAPILLTKKNNIPNATLKRVEKAKKVY
                     IIGGESSIDKATETFLKDKGIETRRLQGNDRIKTSYNVAKEINSINKVNKVILTNAFK
                     GEPDAMSAAPVAVRDKAAIVLTDGKSVPFNTTGIESYAIGGTSSMSDSLVNDTNSTRL
                     GGVDRYDTNKKIVNKFYNGAKEFYIASGTDLVYALVASPMAKNNPIVLVDIGSNKDIL
                     KNAAKVTGIGNLSDKIMLECENTINNISLPSSNKNIICGLKIDFDSNHIIWQDKGSYL
                     ECYDDNLEYYTEKYKDPTVPINIENTSTQNLDVTKLKVYGEANSTLYMGQYAKIKMDF
                     NSFGVLKPGEKCTIYLDIISLDPSRSMTLTFSYVGDKENYKYEQGLASRILFYNPDGE
                     DFFEYK"
     gene            6957..8074
                     /locus_tag="KNP36_002114"
                     /pseudo
     CDS             6957..8074
                     /locus_tag="KNP36_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861579.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            complement(8437..8517)
                     /locus_tag="KNP36_002115"
                     /pseudo
     CDS             complement(8437..8517)
                     /locus_tag="KNP36_002115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005541856.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
     gene            complement(8557..9225)
                     /locus_tag="KNP36_002116"
     CDS             complement(8557..9225)
                     /locus_tag="KNP36_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBF0873986.1"
                     /translation="METVTNNQSGVEIQLSLFEAIKDLLLINPIFLLGIILIGIFLVV
                     IFKKNSDIPKVKTSILSLAMYYYLCLTLSHIVGIPTFSEYIRLSQLGETFFNPNINLI
                     PFSDGFSLSFILNILLFVPLGFLCPLISKTFERLRNTFLIGFGLSLFIETIQLFTLHR
                     ATDIDDLLTNVIGTIIGYFCFKLIAKLRIVKLHSDDDSMEQDYTVCIPIAIIIVALIL
                     GFFS"
     gene            complement(10078..12498)
                     /locus_tag="KNP36_002117"
     CDS             complement(10078..12498)
                     /locus_tag="KNP36_002117"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HBF0873987.1"
                     /translation="MSVYNFKEVESKWQKIWKDNNQYKMDTAQTEKPNYYTLEMFPYP
                     SGKIHMGHVRNYSIGDVVARFKKMEGYNVLHPMGWDSFGLPAENAAIKHGIHPHKWTM
                     ENIEEMKEQLNLLGISYDWDKEVATSTPEYYRFTQEIFLKFLEHGLAYKKKSYVNWCP
                     SCETVLANEQVVQGACERCKATVLKKDLEQWYFKTTEFAEELLNDLDILDGWPEKVKT
                     MQKNWIGKSTGADLVFDIDGTDKSMTVFTTRPDTTYGVTYMVLAPEHELVKELVAGTE
                     YEADVEAFVQKMHTMTEIERTAADVEKEGMFIGRYVINPLNGKKVPLWIANYVLVEYG
                     TGAIMAVPAHDERDRDFAEKYNLDIIDVITEDNKMINSEEFNGLDASEGFEGIIDKLE
                     KEGRGKRTINYRLRDWLVSRQRYWGCPIPVVYCDECGIVPVKKEDLPVLLPTDVEFTG
                     KGESPLTTSKQFMSTTCPHCGKPARREVDTMDTFVDSSWYFLRYVDSNNENEPFSKEL
                     VNRWHPVDQYIGGVEHAIMHLLYARWFVKAFKSMGMVDFNEPFKNLLTQGMVLMDGSK
                     MSKSKGNTVSPMDIIDEYGADTARLFVLFAAPPERDLDWSEQGVDGCFRFLNRVYRLV
                     DELADVVKKDVEFGELNSQDKDMRYTIHSTLKKVTADLSEKFGFNTAISALMELINDM
                     YKYKELDNINEAVIKEGVQTIVTIIAPFAPHLGEELWTMIGKEGSVFDIDWPKYDEKA
                     LVKDEIEVVVQVNGKVRGKLTVNSNISKDEMEKVALEDEKIKGLVEGKTIVKVVAVPK
                     KLVNIVVK"
     gene            complement(12852..13202)
                     /gene="rsfS"
                     /locus_tag="KNP36_002118"
     CDS             complement(12852..13202)
                     /gene="rsfS"
                     /locus_tag="KNP36_002118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HBF0873988.1"
                     /translation="MTVEQMTKIAYDAIEDKLGQDTVIINIGKVSSLCDYFIITTASS
                     QRQVKAIADNVEDELAKLGLEPRGKEGQGTQTWVLLDYGDIMVHVFNEENRGFYNLEK
                     LWKDAPYIDIDTLA"
     gene            complement(13319..13891)
                     /gene="yqeK"
                     /locus_tag="KNP36_002119"
     CDS             complement(13319..13891)
                     /gene="yqeK"
                     /locus_tag="KNP36_002119"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HBF0873989.1"
                     /translation="MNLENINQRLNQMLPVGRLSHSKNVAKCAEKLCEIYGCDKEKAY
                     LAGMIHDCAKYLSDKEIEDYVNKYEIYLDPIEDGNRSLSHSVIGAYICEYEFEVEDED
                     IINAIKYHTTGREDMSLLEKIIYIADLIEEGRKFPVVDTLRELAYGGKLDEALLTSFN
                     NTLMFVINKKEEIHPRTVMARNYLIKEKLL"
     gene            complement(13892..14581)
                     /locus_tag="KNP36_002120"
     CDS             complement(13892..14581)
                     /locus_tag="KNP36_002120"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HBF0873990.1"
                     /translation="MRSENLVKMAELKNTEKLEKFNRHKGKIKIGILGGTFDPIHYAH
                     LATAEFIRDKYDIDKIIFIPSGNPPHKLCITTDKYDRYNMTLLATESNEDFLVSKVEI
                     ERKKRTYTIDTLKYLKKKYKNADIYFITGADAICSVEEWKDVKKNFELATFIAATRPG
                     ISLLRSQETIEKLTKKYNADIITVYVPSLDISSTYIREQLNEGKSIRYLVPENVENYL
                     YENKLYQYGDD"
     gene            14857..15495
                     /gene="recX"
                     /locus_tag="KNP36_002121"
     CDS             14857..15495
                     /gene="recX"
                     /locus_tag="KNP36_002121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HBF0873991.1"
                     /translation="MGIITKIEQQKRNDDRVNIYVDDKFFIAIFKELVYTFNLKKGNE
                     INEEELKPILDDEMYIKAKNKALNILSHADQSEKKLKEKLSSEFDENIIERVIDFLKS
                     YNLVNDSVLAQKIVNTNVNLNKCGKNRIKQNLYNKGINRSTINEAVSELDKDTEFENA
                     MYLAKKRYERVKKEDKKKIYQKISQHLSYKGFDYDIIKRVLNKLLNFDEYDI"
     gene            15648..17651
                     /locus_tag="KNP36_002122"
     CDS             15648..17651
                     /locus_tag="KNP36_002122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha amylase C-terminal domain-containing
                     protein"
                     /protein_id="HBF0873992.1"
                     /translation="MKSQKRFKILDIDVYLQPFESDIKKRMKHYEDMKSKTLKNYKDF
                     SSFANAHLYYGFHQTNDGFFYREWAPNADSLSLIGDFNNWNRKSHPLRKIGSGNWEIF
                     IPGQNSLPHKSEVKVQVTANGKTFDRIPLYIKRVIQKDFGGFNGQIWQPKTPFIWTDN
                     DFDLKNITSPLIYECHIGMSTESESIGTYNEFTEKILPKIKKAGYNTIQLMAIMEHPY
                     YASFGYQVSNFYAISSRFGTPEDLKNLINTAHSMGIAVLLDLVHSHAVKNTLEGINEF
                     DGSEHQFFHSGSKGNHPAWGTKLFNYGKPEVIHFLLSNIKFWLNEYHFDGFRFDGVTS
                     MLYHNHGLGVSFDSYEKYFSMNTDIEAITYLQFANELMKEIKPNSISIAEDMSGMPGM
                     CIPIKDGGIGFDYRLAMGVPDFWIKTISNLSDEDWDLGKMWYELTTRRPGEKNIGYCE
                     SHDQALVGDKTIIFWLADKEMYWNMEINSNNHVINRAISLIKLIKLITFSLAGEGYLN
                     FMGNEFGHPEWIDFPREGNNWSYKYARRQWSLSEDNNLKYKQLLNFDKSMLELTKYSD
                     IFIQNSHELIHMDNDKKILVYSKGKYLFIFNFHPNLIQSVDISKFQNTNYKTILNTDM
                     VEFGGNTKKENLRDYDVYFSSTPPSSKMPIASRTAIVLLDNGI"
     gene            17825..18466
                     /locus_tag="KNP36_002123"
     CDS             17825..18466
                     /locus_tag="KNP36_002123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0873993.1"
                     /translation="MGRKKEPDNTIQKILDISHKLFLEKGYEQTTIQDIVDNLDGLSR
                     GAIYHHFKSKDEIIKAITSRLYNDGFYGYEVKNDEGKTALEKLQYRLLHTYEQHNKQD
                     IFLMSSSLLRNPKYLATQFDEIINDIVPWIKALIEEGNQDNSMEVKNPEIAAQMFGFL
                     LNTWCIPTVYPGNPQQMIERFTLFGEQAAFMGISFMNDKIMCEYQKFVNKFSK"
     gene            18559..19242
                     /locus_tag="KNP36_002124"
     CDS             18559..19242
                     /locus_tag="KNP36_002124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0873994.1"
                     /translation="MQKEVAMNKLIKDCVNFFNDCGFSYSICGGYALELFANMHIRPH
                     SDIDIWISDTDKEKSIQYMLNQGWDIYEPLGNYLLRPIIDLNKQHIEQICVFAIKPDC
                     SFIELKKVEDDNYKMNIQCDEQLQFDFIELIYNPQKDGKFLFSQNQRIIRDMDKARLI
                     TSDNIPYMAPEVVLFCKSIYIDRLGYQKDFDVTVPLLSQEQRDWLVNALITAYPDGHA
                     WIDQLANQY"
     gene            complement(19419..19730)
                     /locus_tag="KNP36_002125"
     CDS             complement(19419..19730)
                     /locus_tag="KNP36_002125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="HBF0873995.1"
                     /translation="MKIITEIVEFNVEENLSKEEFIEIVNDLELKFHSIQSGFIDTEL
                     LYDEKSQKWIMIQHWESIEDLKSVSSKMFKDSSTEKFRKALKNQTVKMNIIPQIKSWK
                     L"
     gene            complement(19808..20626)
                     /locus_tag="KNP36_002126"
     CDS             complement(19808..20626)
                     /locus_tag="KNP36_002126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0873996.1"
                     /translation="MLSVTRYSIKNVRLKPWVKFIWYFETKSNILLNNKLLPTDSIDI
                     ILNLSDVMEYKIENQDYIASNIHFNGIRDKHGFIIQHGNIRVIGISFYPFGLYPFLKI
                     PISEFNRQIVDLEAVSKLFAKKLEESLNPTKAIEKVVLCLEEVLLSILEEDLISNKYV
                     KLLNSFIYVNRYSNIKAFCDDTNINIKTLERICLKYTGYTPKILKRIYRFKMASNQLI
                     YNYKDDELFDFIYENEYYDQAHFIKEFKKFSGTSPIKFSGENKTIKENIKYSYL"
     gene            complement(20726..21250)
                     /locus_tag="KNP36_002127"
     CDS             complement(20726..21250)
                     /locus_tag="KNP36_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBF0873997.1"
                     /translation="MEVTAKQKFTTKDMVETSLLIALVFIATKFINIRLPISINGGLV
                     HLGTAMLFISAIVFGSKKGALSGAIGMSLFDLISGWTLWAPFTFIVRGVMGYLLGKIA
                     WANGNNGNNFLINVIGICVSSIWMLFGYYVTEVILYGNFIVPLTSIPGNLMQVLIGLI
                     IALPISKVLKKCIK"
     gene            complement(21269..22411)
                     /locus_tag="KNP36_002128"
     CDS             complement(21269..22411)
                     /locus_tag="KNP36_002128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBF0873998.1"
                     /translation="MNKKINYAPGPTETRENVRLARAEKTTNPDIDIDFVEFYKKTCE
                     KFGNIIGTKNDVYILSGEGILGLEAACASLTEKGDRVLVIDNGIYGEGFKDFVTMYGG
                     EYVLFSSEYTKSIDIDELKAFLDEDSNFKYATVVHCDTPTGVLNDVSKICPLLKEYGI
                     LTVVDSVAGMVGERLSVDESKIDIILGGSQKAISAPAGLTIVGISQDAKNCIKNRKTD
                     VIGFYCNLNIWEGYYEKKYFPYTMPISDIMGLDKALDNILEEGIENVLNRHEKIAYSV
                     RKSIEEYGLELFLEEGYSNTVTAIKIPESIGALELTDYMLKNYNTLVATSLNQYMDTI
                     LRIGHMGENANLNKIEHVLNVLDKSLSALGFKGNGNLLNLFNKYYF"
     gene            complement(22691..25078)
                     /locus_tag="KNP36_002129"
     CDS             complement(22691..25078)
                     /locus_tag="KNP36_002129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0873999.1"
                     /translation="MINTTKIAKSNLKQNKSKSILIIITIILSTLMLSSIGIYIVDAG
                     AYQKENTIKYSGNYQGILANVDEKQADILSNHADVELTGKMNGVGVEKLEDDSNISLA
                     YMNEDALKLNSFEFIKGKLPSKENEIVLDSGALKALGYKNKDLGEKIKISYNDYKSDK
                     KIEKEFIISGILKTSEISEAGKYYYAIISESYMRNTRDMSQEDFNIYVKLNDKSNLSI
                     EQAKSKLNKIANDVGLDTINVAVNENYINALKPDMETIMGGVFVGLVIVLSSILVIYN
                     IFYISIVTKVQEFGKLRAIGATKKQVKNIVFKEGFILAGIAIPIGIILGYVLANIIIK
                     SFMDIDVKSSRLPVILSVVVISFISVVLSLLKPMKVASKVSIVDAVRYTGNKISNKSK
                     RKGYKNINLKRLSHANLERNKKRTYMTLASLILSGTIFITVSTALESFDAEKMAREHF
                     PYDIEVRLSGYEMNSDKNPKDNLNILQMDNPLSKDFFNQIKNMEGIKRIESARSVKIG
                     MEDYDVEFKYDLLQSINENDVKSLNKNIIDGKINLERLQTGDEIVITHVDTAKEMGVK
                     AGDKIRLTLYDGDKKIKKEFKVQAIAMGVPSFGIGKDFIDRTLKYDSTSSLGIYTEEG
                     KYQEIKDSIKKIAKNNGFLETDFIDSRIESNKATISFIKIMGYTLTGIIGVIGFMNLV
                     NTMITSIVTRKKELGMLQAIGLTNKQLVKMLNSEAMYYTSGMMIGSILFGGILGYIAV
                     IFLKKTGLSYATYSLPIVPILLMIVCILIAQFITTYLIGRSFNKESLIDRVRYSE"
     gene            complement(25071..25754)
                     /locus_tag="KNP36_002130"
     CDS             complement(25071..25754)
                     /locus_tag="KNP36_002130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874000.1"
                     /translation="MKILYTENLSKHYGKGESLVRALDNVDLEINEGEFVAIIGKSGS
                     GKSTLLHMIGGLDIPTSGKVYIDNKNIFTLKEEELAVFRRRKIGFIFQSYNLIPSLNV
                     WENVVLPIGLDGREVDEPFIKELLKSLGLENKHDVLPNTLSGGQQQRVAIARALATRP
                     AIILADEPTGNLDSKTSDEVMSILKSMSKKYSQTLVMITHDDSIAQMADRVIFIEDGR
                     VSKVGDKND"
     gene            complement(25871..>26728)
                     /locus_tag="KNP36_002131"
     CDS             complement(25871..>26728)
                     /locus_tag="KNP36_002131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874001.1"
                     /translation="FIVDKMSQENYLKDTTESEETGYLVEYNEYFKEGIFSKINNCLY
                     ELNRSLKIKFIKLEKEKESVKSLVTDISHQLKTPLASLKLYNTLLIEEELEEDEANEF
                     LLTNKASINKLENLINSLVNISRLEISMINIKKEDNDIKNTILNAVKSVTPKAKSKSI
                     TLNLNEFNSRIIPHDKKWTEESIFNVLDNAVKYTQVNGEINISVEETANFFKIIIEDN
                     GIGIEKSEFNNIFKRFYRGSADEIESVEGSGVGLYLSRKILEEQGGNIIVSSKVGIGS
                     KFSLFLTTM"
BASE COUNT         9131 a         4252 c         3318 g        10027 t
ORIGIN      
        1 ttcaatataa aagaaagttt tactttattt ttattcaaaa ttagaaaact atacatatat
       61 aataaaatac aataaaaaaa ctaaggtgat aattaaattg aatatttatt ttatataaca
      121 atcatttttt attaaaaggt attttttatt ttaacatata tttaataagg ctaaatagag
      181 ttattatttt aatttcatac tttacttttt ctataaacct attataatta aagtataatc
      241 atttttgcaa cttgtttatt ttattataaa aatgtgaaac ttattacata aggaggaatt
      301 taacatgaaa aatcatactt ataaagaaat caaaaacata tatggaaaaa taagcccttt
      361 tgaatttaag gacaaattaa tagatattgc aaaatacact gcaaaagaaa ataacagaga
      421 attacttgat gcaggtcgtg gaaatccaaa ctggacttgt tcaactgcta gagaagcctt
      481 ttttactttt ggtcatttcg ctattactga aactcgttct aattgggatt taggtcattt
      541 ggctggaatg cctcaaaaaa agggtattaa agaaagattt tttaaattta taaatgaaaa
      601 tatagatatg cctggagcat atttagctag agatattata aactttggta taaatgaact
      661 tggatttgat ggagatgaat ttgttcatga actagctgat ggaattattg gtgataacta
      721 tccacttcca gatagaatgt tacctcatat ggaaaaaata gtacacgatt acctagttca
      781 agaaatgaaa tatgatatat caggtaaata tggtgatgta gaaatttttg ctgttgaagg
      841 tgctacagct gctatgtgct atatatttga ttcattaatg gcaaatgaac ttctaaaaaa
      901 aggagatacc atagccttaa tgactccaat atttacacct tatcttgaaa tacctaacct
      961 tcctcgttac gactttaaag tggtaaatat aaatgctaat gaagttgatg aaaaaggtgc
     1021 tcatacatgg caatatacaa aaaaagaatt agagaaactt cgtgacaaat ctattaaagc
     1081 tttattcgtt gttaatccta ataatcctgc ttctatagct atggatgaaa catcttgtaa
     1141 taatctaata gatgtaattg aaaattataa taaagattta atgataatat cagatgatgt
     1201 atatggaact tttgtagaag atttttcatc cttaatgtca aaactacctt acaacactgt
     1261 tggagtatat tcttattcaa aatattttgg agttacagga tggagacttg gtacatttgc
     1321 ccttcataag aaaaatgttt ttgataagaa aataaatgat ttaactggag aattaaaaaa
     1381 atcagtagat aagcgttaca gtgatatgag tcttaaccct tctagccttt catttatgga
     1441 aagagttgtt gctgatagca gacttgttgc tctcaaccat actgctggtc tttctactcc
     1501 acagcaagta caaatggcgt ttttctctgc ttttgcattg attgacaaag tagatgccta
     1561 caaaaaactc aatatgagta tctgccatag acgtcaaaaa ctattatttg aagctttaga
     1621 gcttccaatt aatgaaaaca aaaacaatgc tgcatattac actcaatttg atattgaaga
     1681 atgggctaaa ttaaactacg gagaagactt atttaaattt ataagtaaaa ctgcatctcc
     1741 agtagatgtt ctttataaat tagctaatga ctattcagta gttttactta gtggaaatgg
     1801 attctatggt cctgaatggt caattagaat atctctagca aatctatatg atgaagctta
     1861 tactaagata ggaaaagcca taagagagat attaaatggt tatatcgttg aatggcaaaa
     1921 aattaagaaa taattatatt acactgaaat atctaaatta tatgaataaa agagtttatg
     1981 tagaccttaa ctactttttt tgatataatc ctatcggaat tataaatttt atttatgaaa
     2041 ggcagagaat agtatgagta ttaagaaaaa agttgccata gtttttactg gtggaactat
     2101 atctatgaca gtagatgata aagtcggagc agctatacca actttatcag gtgaacaaat
     2161 actatcaatg gttaccaaca ttgataaagt tgcagatgtt gaagttttta attttgatga
     2221 aattccagga cctcacataa caccttatag aatgatggaa ttgaaaaatt atgtaaatga
     2281 tttattagca agaaaagata ttacaggtgt tgtaataaca catggtacag atagtttaga
     2341 ggaaacagct tattttctag accttacaat tgacaacatc aaacctgtaa tagtcacagg
     2401 tgctatgaga agtagttctg aacttggata tgatggttca agtaatttat ctgcatcagt
     2461 ttgtactgca gtatccaaag atgctatggg aaaaggagtc cttgtagttt taaacaatga
     2521 agtattatta gcttctgaag ctactaaaac aaatactctt tctctaaata catttaaatc
     2581 tctaactagt ggcccattag gaataattga ctgcaacgaa cttgtcctta caagagatat
     2641 tgtaaataga acaattatag atactgataa ggtagaatct aaagttgcct tatttaaagc
     2701 atatgtagga gaaaatgctg actttataag atttgctgtt gatagtggtt ataaaggtat
     2761 agttattgag gcaatgggta gaggtaatat tcctcctcaa atgctttctg gagttgaata
     2821 tgctagagaa aaaggacttc ctgtagttat agtttctaga tgtcattcag gtagagtatt
     2881 cgatagttat ggttactttg gttctggtag agatttaaaa aatcttggtt gtatatttgg
     2941 tggggactta ccaggtcaaa aagctagaat aaaacttatc ttagcacttg gaaaaactga
     3001 taaccttgat gaaatcaaag atttctttga aaaaggaatc tattgttaat tctaataact
     3061 tctatttaat tatttattga tatttcaaca tttttaaatc aaaatctaat acttatgtca
     3121 gttaaatgtc agcaaaatat tttatccaca agttttccac aacttatccc caatattatc
     3181 cacaagaaaa aaggtagcac ttatattagt agctaccttt tatttattaa tcttcatctt
     3241 tccagctttt tatccaattt cctatttcta ttattttttc ttcagttatt tcttctccat
     3301 catgcaattt tgaaattaat tctgataatg gattgttatg tagacctcca aaaattcttt
     3361 ttccctctat tttgagatat tctttctctt ttattaatac tctatagtgt acatgtttcc
     3421 caattctctg cgatatgaaa aaaccttttt tagttaatct agctaaaagt gtaattgtag
     3481 ttgtatgctt ccaagcatat gttttttcta tttcatctgc aacatctttt gatattacag
     3541 ttttataacc agtattctat atgtatttca taatttttaa ttctgcatct ggtaattttt
     3601 tattcaacat aatatattcc ttctttcaat ttatgtcact tcctcaaact tatctagctt
     3661 aaattaataa taggagcttt ttatcacaaa aactacaggt aaatttttct atatattcta
     3721 cgtatttagt ctgtttttta agtgtgaaat tacgttcata cctataaatt tattcaattt
     3781 tcaaacaatc ttattgaata ataactaatt ctattgtatt atttagttat agaataaaac
     3841 taaatcggca aaactagaga aatctagtga cgcaaagcta tagagactaa gacttatata
     3901 aatatcttat gagttatgtc agccagttgc caaagagata ttgttctttt tgtttttatg
     3961 aaagtttttt agggggataa taatttatat atttagagat aaaatagata aatgtacaca
     4021 tatattgact gcttatatta gcagttcgta tgattattgt aattttttgg atacaattta
     4081 cattccatat agttaatata aaacaagtgt ttcgaatttc ttttctgaaa ctataccaac
     4141 aatttacatt ccatatagtt aatataaaac gttatatact gaaagcggtg aaactggtta
     4201 cgtagcaatt tacattccat atagttaata taaaacctgt gcgtgtagga gatggtaaca
     4261 caactgttga agaatttaca ttccatatag ttaatataaa acacacatct acatgttttt
     4321 ctatctgagt tcatctctaa tttacattcc atatagttaa tataaaactt tttaatcctt
     4381 cttctgaact cccaaagttt atatcattta cattccatat agttaatata aaacccacga
     4441 aatttaaggt cgatatatca gatttgaaaa aatttacatt ccatatagtt aatataaaac
     4501 aagctaaatg gagcaaccga ccaagtcgct agaaataatt tacattccat atagttaata
     4561 taaaactttt ctattaagtg taagcagaat gcatggaata tgaaatttac attccatata
     4621 gttaatataa aaccccaaaa taaattgagt atttccaatg cctacacata tacaaatctc
     4681 tcaaatttgc agtgaaccat gagtagtgca attgataaca cttatcacaa gtcctcaatg
     4741 ccttatattt caactgttaa gccttaattt cttcaaaaaa tcgaacactg caaaatttct
     4801 atgactttat tatatcataa aaatattatt tttgaatatc tgtaccaatt tgtgatataa
     4861 taaaagcaag aagaactaca atctattttg ctgtagagtg gagttcataa tttagaaatt
     4921 acttagtttt atggaatctg atttttaaat caaattccca accactctta gttgccgctt
     4981 tgagtggttt tttacgcttt ctaaatagtt tgctagctat ataaactatt aagctagcag
     5041 atagacttgc tagtatgcct tgtaaaaaat tatccatgta tattcacctc ccttcttaac
     5101 gtcgggagga taattttttg atacatgaac tccactctat aaattgtaga ttacatcttc
     5161 ttgctaaaaa tattataaca tataattctt acatatttta cctatttatt actttttaca
     5221 ttataataat attcttttaa tcaaaaaaac acctactatt aaaataaatg tttttaagta
     5281 tttttaattt taaaatccat atagttcata tgaaactaaa tataataact caacatatga
     5341 gcaatatcga gacatttaca tacccactag ttatttatat tcaaaaaaat cttctccatc
     5401 cgggttataa aataatattc tacttgccaa tccttgttca tatttataat tttctttatc
     5461 acctacataa gaaaatgtta atgtcatgct tcttgatgga tctaatgaaa ttatatctaa
     5521 ataaatagta catttttctc ctggctttaa tacaccgaaa ctattaaaat ccatttttat
     5581 tttagcgtat tgccccatat ataatgttga attagcttct ccataaactt ttaattttgt
     5641 tacatctaaa ttttgtgtac ttgtattttc tatatttata ggaactgttg ggtctttata
     5701 tttttcagta taatattcaa ggttatcatc ataacattca agataacttc ctttatcttg
     5761 ccaaattatg tgatttgaat caaaatcaat ctttaatcca catattatat ttttatttga
     5821 agatggaaga ctaatattat tgatggtatt ttcacactct agcataattt tatcacttag
     5881 atttcctatc ccggttactt ttgcagcatt tttaagtata tctttattac ttccaatatc
     5941 aactagtaca ataggattat ttttagccat tggtgaagca actaaagcat aaactaaatc
     6001 agtaccacta gctatataaa attcttttgc gccattatag aacttattta ctattttttt
     6061 attagtatca tatctatcta ctccacccaa tcgagttgaa ttagtatcat ttactaaact
     6121 atcactcatt gatgaagtgc cacctattgc ataactttct ataccagttg tattaaatgg
     6181 aacacttttt ccatcagtta atactatagc tgctttatct ctaactgcta caggtgcagc
     6241 actcatagca tctggctcac ctttgaaagc gttagttaat attactttat ttactttatt
     6301 aatggaattt atttcttttg ctacattata acttgtctta atcctatcat taccttgaag
     6361 ccttctagtc tctattcctt tatcttttag aaaagtttct gttgctttat caatggaact
     6421 ttctcctcct attatgtata cctttttagc tttttctact cttttaagag ttgcattagg
     6481 tatattattc tttttagtca aaaggattgg tgcatttgtt gctcctgcaa gtccactcgc
     6541 acttagccca tcagccattg tactatctgc atttataagt attgcagtag tataactttg
     6601 tttgtcagct atgataccag cagtttcgta tttatctgct ccttgaattt tatcaatttt
     6661 atcaagtgca ttagctgata taggaaaacc agcaacaaac attgacacta accctagtga
     6721 taataatttc tttaatttca caatatctcc cccttttata tatgaaatac tatatatctt
     6781 aataattcta cattaaattt tcttttcctc ctttaacgat atttatcttc ctgttaattt
     6841 aagtgtatac aaatacgtgt tataatgtaa ctgtaaagaa ttaaaaagat aatgacataa
     6901 ttagagtagt acaactgttc ttttataaaa ctaacttata aagggagcgt acatatatga
     6961 atatcaaatc agcttttata agaaaaagag gggaaaaatt ctatgtatat gtggagtaca
     7021 tagaggaaac aactggcaag ataaaacaga aaagttatgg aagttatgaa aagaaaaagg
     7081 atgctgaaaa acatttaatt gaaataaaat ctactataaa caataataag tttgttgctc
     7141 caaaagatat gacatttgta gaaagatgtt ataaatacat ggacatgaat aaaaataatt
     7201 ggtctccata tactgttaca aatacaaaat cttgggttaa aaattacata gaacctcttt
     7261 ttaagaatct aaaactcaca gaagtaaatc ctagttcagt acaagctttt gtaaattata
     7321 actttaataa ttctaccttt actagtgcta aagtaaggta tagctttcta agttctgtaa
     7381 taagggaagc atatagatta agagaaatac aagaaaattc atgtgatttt ataaaacttc
     7441 cttctaaaga aaaatattct acaaatgaaa tatacaatag aaaagaagta ttattgctaa
     7501 tagaaaagtt acttagtaat aatatagaaa tacctattct tttaatgtta cttctaggtt
     7561 taagaatggg agaagctact gggcttaggt ggtcagatgt tgacttagat aacaatctga
     7621 taaatgttaa tcaaattctt gtctattcta atggcaaaat atcttttaaa gagccaaaaa
     7681 caccaaaatc aaaaagagct ttatcagctc caaaagaatt aattgaaaaa ttgaaaatta
     7741 aaaaactaag acaaagcaaa ttaaaattgt aaggtatcct ggaaaacaga aataatttag
     7801 tttgtctaaa caccaattta aatccgtttc taccttcttc actaagaaaa acgtttcaca
     7861 attttacaaa aaaaataatt taaaaaagat tagaatacat gatttaagat atacaagtgc
     7921 cactctgctg cttttagggg gaactaatat gaaagttgtt tctgaaagat tgggtcatac
     7981 agatataaaa ataactatga atagatattc tcatgtactt aaagaaatgg acaaagaagc
     8041 ttccgacaat ctaagcgaac ttctatttaa atagtaaaaa ctgactgtca gttaaatgtc
     8101 agttaaacct aaaaaaatag gttttgtcag ttgattatca gtcaattatt ttataatagt
     8161 ttcacttaaa aacgtctata tctacacatt ttactatttg tttatgctta ttaatatcta
     8221 tctgttatta ttaattctaa tagcttctat ttaattattt agttcagttt acaggaaact
     8281 acacacaaac cataaaatag gatgttgaca atataacaga tagtatgctc ctgtaaaagg
     8341 taacgtacta tctgttatgt tgtctggatt tccaaatggt taccctttgg cacacaactt
     8401 tgctatctcc ttggtaaact aaaagtttgt aatctaaaat cctaatccat ctctataaaa
     8461 tttaattgac ttctccatac tttttacacc taaacatata aaagtaattt tattcactta
     8521 atgacctcca taattcccaa attagctatt tggaacttaa ctaaaaaatc ctaatataag
     8581 ggcaactatt ataatggcaa tcggaataca tactgtgtaa tcctgttcca tagagtcatc
     8641 atctgaatgt agttttacaa ttcgcaattt agcaatcagt ttgaagcaga aatagcctat
     8701 tattgttcca attacattcg tgagtaagtc gtctatatcg gttgctctgt gtaacgtaaa
     8761 aagctgaata gtttcgataa aaagagataa tccaaaacca atcaagaatg tatttctcaa
     8821 acgttcaaag gttttgctga taagcggaca taaaaaacct aatgggacaa aaagtaaaat
     8881 attcaaaata aaactcaaac taaatccatc actaaaagga ataagattta tgtttggatt
     8941 aaagaacgtt tcccctaact gtgacagtct tatatattca ctgaatgtag ggataccaac
     9001 aatatgcgat agtgttaaac ataagtagta atacattgcc agtgataaaa tagatgtttt
     9061 tacctttgga atatcactat ttttcttgaa tattacaact aagaaaatac caatcaagat
     9121 aattcccaac aagaaaatag gattaattaa caataaatct ttgatagctt caaacagact
     9181 gagttgaatt tctacacctg attgattatt tgttacagtc tccatttgta catacctcct
     9241 cataacattt caattatttc taaaacacaa aatagaagat aaatcttaaa atcatcctat
     9301 caaaattttt aaatttgcct ttatcagttt ataccaccag ttaattcctg tcttacttct
     9361 gtatggtatt cttgggattc tttcatcaaa ttagacaaaa aatggttacc atatcaataa
     9421 actggttacg ctccatatct cccgaagcaa ccatcccctg agaataaatc cgtatcagga
     9481 atctccacat ctactgcacc tatcacaagt tatttgataa catcctcaga caatcccaac
     9541 ttggatatat cgacaacacc cattagaata ccactgctga ccatacttgt tttcctgctg
     9601 ataattttaa tcaactggga agttgaaacg ctatcttttt tacaagttcc tttttagaaa
     9661 catggtagct attatatgaa tctgaatttc gttgtctggg tgtttcatat aaagcataga
     9721 tacgcacctt ttttgcctgt tttcattata tagaaaaaaa tttcaaaata caataattat
     9781 atttttttcg tttaagctta gagcagttcc ttgatgaaca acactttgga aactgaatga
     9841 tttacatacc acttaataca ttaactcgat ttaacattaa ttataataat atttaaaaca
     9901 acaactaggg tatataagaa tgaacttttt agttctttaa tcattttttt gtataaaatc
     9961 aaatctattt ttataatttc aacaatttta taatttcaac aatgaaaaaa ggcttatctc
    10021 tattttgaga cagcctcgtt tattttataa atttatattt ttgttcatat ttttgagtta
    10081 tttaacaact atatttacta gttttttagg tacagctaca actttaacta tagttttacc
    10141 ttcaactaat ccttttattt tttcatcttc taaagctacc ttttccatct catctttaga
    10201 tatatttgag ttaacagtta attttcctct aacttttcca ttaacttgta caacaacttc
    10261 tatttcatct tttactaaag ctttttcgtc atatttaggc cagtctatgt caaatacact
    10321 tccttcttta cctatcatag tccatagttc ttcacctaaa tgaggggcaa atggtgcaat
    10381 tatagttact atagtttgta caccttcttt tataactgct tcgtttatat tatctaactc
    10441 tttatattta tacatatcat ttattaattc cataagagct gatatagcag tattaaatcc
    10501 gaatttttca cttaaatcag cagtaacttt tttaagtgta gagtgtatag tatatctcat
    10561 atccttatct tgggaattta attctccaaa ctctacatcc tttttaacca catctgctaa
    10621 ctcgtcaacc aatctataaa ccctatttaa gaatctaaag catccatcaa caccttgctc
    10681 tgaccagtcc aaatctcttt ctggtggtgc tgcaaataat acgaaaagtc ttgcagtatc
    10741 tgctccatac tcatctatta tatccatagg agatactgta ttccctttag acttactcat
    10801 tttagaacca tccataagta ccattccttg agtaagtaag tttttaaatg gctcattgaa
    10861 gtctaccatt cccatactct taaatgcctt tacaaaccat cttgcataaa gtaaatgcat
    10921 tatagcatgt tctactccac ctatatattg gtctactgga tgccatctat taactaattc
    10981 cttactaaat ggttcatttt cattattgct atccacatat cttaagaaat accaagaaga
    11041 atcaacgaat gtatccatag tatcaacttc ccttctagct ggttttccac agtgaggaca
    11101 agttgttgac ataaattgct ttgaagtcgt aagtggagat tccccttttc cagtaaattc
    11161 aacatctgtt ggtaaaagaa ctggtaaatc ttccttttta actggaacta ttccacattc
    11221 atcacaataa accacaggta taggacaacc ccagtatctt tgtcttgaaa ctaaccagtc
    11281 tctaagtcta taattaattg ttctctttcc tctaccttct ttttctaact tatcgattat
    11341 tccttcaaat ccttctgaag catctaatcc attaaattct tctgaattta tcattttgtt
    11401 atcttctgtt attacatcaa ttatgtctaa attatatttt tcagcaaaat ctctatctct
    11461 ttcatcatgt gctggaactg ccattatagc acctgttcca tactcaacta atacatagtt
    11521 agctatccat agaggaactt tcttgccatt taaaggattt ataacatatc tacctataaa
    11581 cattccttct ttttctacat cagctgctgt tctttctatt tctgtcatag tatgcatttt
    11641 ttgaacaaaa gcttcaacat ctgcttcata ttcagtccct gcaaccaatt ctttaactaa
    11701 ttcatgctct ggagcaagta ccatataagt aactccataa gttgtgtctg gtctagttgt
    11761 aaatactgtc atagatttat cagttccatc tatatcaaaa actaaatctg ctcctgtact
    11821 tttacctatc caattttttt gcattgtttt aactttttct ggccatccat ctaatatatc
    11881 taagtcatta agtaattctt ctgcaaattc agtagtctta aaataccatt gttctaaatc
    11941 tttctttaat actgttgctt tacatctctc acatgctcct tgaacaactt gctcatttgc
    12001 aagaacagtc tcacaagaag gacaccagtt aacatatgat tttttcttat atgcaagccc
    12061 atgctctaaa aacttcaaaa atatttcttg tgtaaatcta tagtattctg gcgttgaagt
    12121 tgcaacttct ttatcccaat cataactaat acctaataaa tttaattgct ctttcatttc
    12181 ttctatattt tccattgtcc atttatgtgg atgtattcca tgttttatag ctgcattttc
    12241 agctggtaat ccaaaagaat cccatcccat tggatgaagt acattatatc cttccatttt
    12301 tttgaatctt gcgacaacat cacctataga ataatttcta acatgtccca tgtgtatttt
    12361 tccagatgga taagggaaca tttctaatgt gtaataatta ggtttttcag tttgtgcagt
    12421 atccatttta tactgattat tatctttcca gattttttgc catttcgatt ctacttcttt
    12481 aaaattatat acgctcatat tttgcctcct atttttaatt gtgtataact accttattta
    12541 gtattattta cttataattt ccaaataatt ctttgaaaat aaaaaatcct cgtcactaaa
    12601 cttacgttta gggacgagga taaatcttcg cggtaccacc ctaattagcc tactacatat
    12661 atagactctc ttagatagct tttaatccag ccatggagaa tagattttaa tctagtaagt
    12721 tcaaagttat ataatattag ttctcacctt ccactaactc tctgaaaaaa tataatcttt
    12781 tactgctcta gtctattcaa tttaatataa tttttgaaat tttctaatta taataacata
    12841 tattatcatg tttatgctaa tgtgtcaata tctatataag gtgcatcttt ccataatttt
    12901 tctaaattat aaaaccctct attttcctca ttaaatacat gaaccattat gtctccataa
    12961 tcaaggagta cccaagtttg agttccttgt ccttctttac ctcttggctc taatcctagt
    13021 tttgctaatt catcttccac attgtcagca atagctttta cctgtctctg agaagatgct
    13081 gtagtaataa taaaataatc acacaaacta gaaacttttc ctatatttat tataactgta
    13141 tcttgaccca gtttatcttc tatggcatca tatgctattt ttgtcatttg ttccactgtc
    13201 atataaaaat tcctcacttt cctaattaaa atacacttag ttattgtaac atattaatac
    13261 gattttgtaa catagtcaaa tttaaattta ttaatatgtt tgcctttata tagctttttt
    13321 ataataactt ttctttaatt agatagtttc ttgccataac tgttcttgga tgtatctctt
    13381 cttttttatt gatgacaaac attaaagtat tattaaaaga agttaaaagt gcttcatcaa
    13441 gcttccctcc atatgctaat tctcttaatg tatctacaac tgggaatttt cttccttctt
    13501 caattaaatc agctatgtaa attatttttt ctaaaagaga catgtcctct ctccctgttg
    13561 tatgatattt gattgcattt ataatatctt catcttccac ttcaaattca tactcgcata
    13621 tgtacgcccc aattacacta tgagacaagg aacgatttcc atcctctatt gggtctaaat
    13681 atatttcata cttatttaca taatcctcta tttccttgtc acttaaatac tttgcacaat
    13741 catgaatcat tcctgctaag taagcttttt ctttgtcaca tccataaatc tcacataatt
    13801 tttcagcaca ttttgcaaca ttttttgaat ggctaagcct ccccactggt agcatttgat
    13861 ttagtctttg gttaatattt tctaagttca tttaatcatc tccatattga tatagtttat
    13921 tttcatataa ataattttct acattttcgg gtactaagta acgtattgac ttgccttcat
    13981 ttagctgttc ccttatatat gtggacgata tatccagtga tggaacataa actgttataa
    14041 tgtcagcatt atacttctta gttagttttt ctatagtctc ttgtgacctt aacaaactaa
    14101 ttcctggtct agttgcggct ataaaagtag ctaactcaaa gtttttcttt acatctttcc
    14161 actcttcaac actacaaatt gcatctgcac ctgttataaa ataaatgtct gcatttttgt
    14221 attttttctt taagtatttt aatgtatcta ttgtataagt ccttttcttt ctttcgattt
    14281 ctacttttga aactaaaaaa tcttcgttgc tttcagttgc tagaagtgtc atattatatc
    14341 tatcatactt atctgtagtg atacataatt tatgtggtgg atttcctgat ggtataaaga
    14401 ttattttgtc aatgtcatac ttgtctctaa taaattctgc tgttgctaaa tgagcatagt
    14461 gtatagggtc aaaagtacct cccaatatac ctattttgat tttgccttta tggcgattaa
    14521 atttctctag tttttcagta tttttcaact ctgccatctt aactagattt tcacttctca
    14581 tattttgtct ccttttaatg ttataatact attgtaccat tattttttat ttcttaaagc
    14641 ttataatttg tttttttggg tatataatta tatttatatg ctaaaaaaca ctttaaaaaa
    14701 taattattta acataattct gctttacttt ttaataaaaa taacttttta ctattttgtc
    14761 ttaattttga taaaatataa catacaaata taagtttttt gttaaatttt attagttgct
    14821 tttgttaata taattacata taaaaaagga ggacttatgg gtataattac aaaaatagaa
    14881 caacaaaaaa gaaatgatga tagagttaat atttatgtag atgataaatt ttttattgct
    14941 atatttaaag aactggttta tacatttaat ttaaaaaaag ggaatgaaat aaatgaagaa
    15001 gaattaaaac ctattttaga tgatgaaatg tatataaaag ctaaaaataa agcattaaat
    15061 attttatctc atgctgacca atctgaaaaa aaattaaaag aaaaactatc atcagaattt
    15121 gatgaaaata taattgagag ggtcatagat tttcttaaaa gttataatct cgtaaatgac
    15181 agtgtattag ctcaaaaaat tgttaacaca aatgttaacc taaataaatg tggcaaaaac
    15241 agaattaagc agaatttata taataaaggt atcaatagaa gtacaatcaa tgaagcagta
    15301 tctgaattag acaaggacac tgaatttgaa aatgctatgt atctagcaaa aaaaaggtat
    15361 gaaagagtaa agaaagaaga taaaaagaaa atatatcaaa aaatttctca acatctttcc
    15421 tataaaggct ttgattatga tattattaaa agagttttaa acaaactttt aaattttgat
    15481 gaatacgata tataagtata aatactaggg aggtaaatta tgaaattaat cattggtggc
    15541 ttaagctttt tattaggatt atataatata tatcaattat acagagaaga tagtatgaga
    15601 taaatattat tttttagatg taatatttat tatggaggag aaatacaatg aaaagtcaaa
    15661 aaagatttaa aattttagat attgatgtat acctacaacc atttgaatct gatataaaaa
    15721 agcgaatgaa acattatgag gatatgaaat caaaaacatt gaaaaactat aaagatttta
    15781 gttcttttgc aaatgctcat ctttactatg gatttcatca gacaaatgat ggattcttct
    15841 atagggaatg ggctccaaat gcagatagtt tgtcactaat tggtgacttt aataattgga
    15901 atagaaaatc tcatcctcta agaaaaattg ggtctggtaa ttgggaaata tttattcctg
    15961 gtcaaaatag cttacctcac aaatcagagg taaaggtaca agttactgca aatggaaaaa
    16021 catttgaccg tataccatta tatataaaaa gagtaattca aaaagatttt ggtggattta
    16081 atggacaaat atggcaacca aaaactccat ttatctggac tgacaatgat tttgacttaa
    16141 aaaacataac ttctccacta atctatgaat gtcatatagg tatgtctact gaaagcgaat
    16201 ctattggaac ttataatgaa tttactgaaa aaatacttcc taagataaaa aaagctggat
    16261 acaataccat tcagcttatg gctattatgg aacatccata ttatgcatct tttggatacc
    16321 aagtttcaaa cttttatgca atctcatcta ggtttggtac tcctgaagac ttaaaaaacc
    16381 tcataaacac tgctcattca atggggattg ctgttttatt agatttagtt cattctcatg
    16441 ctgtaaagaa tactttagaa ggaataaatg agtttgatgg aagtgaacat caatttttcc
    16501 actcaggttc aaagggaaat catcctgctt ggggtacaaa actttttaac tatggtaaac
    16561 ctgaagtaat acattttttg ctttcaaata taaaattttg gttaaatgag taccattttg
    16621 atggctttag gtttgatggt gtaacttcaa tgttatatca taaccatggt cttggagttt
    16681 catttgatag ttatgaaaaa tattttagta tgaatacaga tattgaagct ataacatatc
    16741 tccaatttgc aaatgaatta atgaaagaaa ttaaacctaa ttcgataagt attgcagaag
    16801 atatgagtgg aatgcctggt atgtgtatcc ctataaaaga cggcggaatt ggatttgact
    16861 atagactcgc aatgggagta cctgattttt ggataaaaac tatctctaac ttatctgatg
    16921 aagactggga tttgggcaaa atgtggtatg aacttactac tagacgacct ggagaaaaaa
    16981 atataggata ttgtgaatcc catgaccaag cattagttgg cgataaaaca attatttttt
    17041 ggctagctga caaggaaatg tactggaata tggaaataaa ctcaaataac catgttatca
    17101 atagagcaat atctcttatt aaattaatta aattaataac tttttctcta gcaggtgaag
    17161 gatatctaaa ttttatggga aatgaatttg gacatcctga gtggattgat tttccacgag
    17221 aaggcaacaa ttggagctat aagtatgcca gaagacaatg gagcctttca gaagataaca
    17281 acttaaagta taaacaatta ttaaattttg ataaatctat gctcgaactt acaaaataca
    17341 gtgatatttt tatccaaaat agtcatgaac ttatacatat ggataatgat aaaaagattt
    17401 tggtgtacag taagggcaaa tatttattta tatttaattt ccaccctaat ctaatacaat
    17461 cagttgatat ttcaaagttt caaaatacaa actacaaaac gatattaaat actgatatgg
    17521 tagagtttgg aggaaacaca aaaaaagaaa acttaagaga ttatgatgta tactttagct
    17581 caactcctcc ttcttctaaa atgcctattg cctctcgtac agcaatagtg cttttagata
    17641 atggtattta aatatgagcc aaatatatta ggaaactgca aatatagtcc agtataaggc
    17701 aaaaaaataa aataatgaaa gcatggcaat atacctgttc aacatgctaa aaagacacat
    17761 tgacaaatca ttatgtattt gctaagataa acataccaaa tgattgtttc gaggagtgag
    17821 ttttttggga agaaaaaaag aacctgataa tactatacaa aaaatacttg atatttcaca
    17881 taagttattc ttagaaaaag ggtatgagca gacaacgatt caagacattg tagataattt
    17941 agatggcctt tcaagaggtg ctatttatca tcactttaaa tcaaaagacg aaataattaa
    18001 ggcaatcaca agtcggttgt ataatgatgg attttatggg tatgaggtaa aaaatgatga
    18061 aggaaagacc gcattagaaa aattacaata taggttgctt catacttatg aacagcacaa
    18121 taaacaagac atttttttaa tgtcatcatc actattgcgt aatcctaagt atttagctac
    18181 gcagtttgat gagattataa atgatattgt gccttggata aaagcattga ttgaagaagg
    18241 aaatcaagat aattctatgg aagttaaaaa tccagagatt gctgctcaaa tgtttggttt
    18301 tcttctaaac acatggtgta ttccaacagt ttatccaggt aatccacaac agatgataga
    18361 acgttttact ttgtttggtg agcaagctgc ttttatgggt atttctttta tgaatgataa
    18421 gataatgtgt gaatatcaaa aatttgttaa taaattttct aaatagtaaa tataaaactg
    18481 ccttaatatc ggcagtttta tatttacaca aaacaaacat ttagttggta ttttaaaaaa
    18541 tttaatttat ttcagtacat gcaaaaggag gttgctatga acaaactaat taaagattgt
    18601 gtaaactttt ttaatgattg tggcttttca tattcaatat gtggtggata tgccctagaa
    18661 ttatttgcga atatgcatat tcgcccacac agtgatattg acatatggat ttctgacaca
    18721 gataaagaaa agagcattca gtatatgctt aatcaaggat gggatatata tgagcccttg
    18781 ggtaattatt tattacgacc tattatcgac cttaacaagc aacatataga gcaaatttgt
    18841 gtttttgcga ttaagcctga ttgctcattt attgaattaa aaaaagtcga ggatgataac
    18901 tataaaatga atatacagtg tgacgaacag ttacagttcg attttattga attgatatat
    18961 aatccacaga aagatggaaa atttcttttt tcccaaaatc aaagaattat aagagatatg
    19021 gataaggcca gactgataac atcagataat atcccatata tggctcccga agtggttttg
    19081 ttttgcaaat caatatacat agataggctt ggttatcaaa aagacttcga tgtaacagtc
    19141 ccactattat cacaagagca aagggattgg cttgtaaatg ctttaataac agcatatcca
    19201 gatggacatg catggattga ccaattggca aatcagtatt aagcctttta gctcccgaat
    19261 atgacattat gataatccac actctaacag tttgttggtt tttctagtat ataacactca
    19321 tattaaaata aacactaaaa gccaaataac aatttaaata caaaatgtta tttggctaat
    19381 ttagtttgat actatttaac tatcttttac attcagttct ataatttcca acttttaatt
    19441 tgtggtatta tattcatctt aacagtttga ttctttaaag cttttctaaa tttctcagtt
    19501 gaagaatctt taaacatttt actagaaaca ctcttgaggt cttctataga ttcccaatgt
    19561 tgtatcataa tccacttttg agacttttca tcatataaaa gctcagtatc aataaaacca
    19621 gattgaatag aatgaaattt taattctaag tcatttacaa tttctataaa ctcttctttt
    19681 gataaatttt cttccacatt aaactcaact atttctgtaa taattttcat atgtaaaacc
    19741 tccaatttat tttcctatat catatcaaaa aataaattgg aggtattgta aaaaatcgac
    19801 agtataatta taaatagctg tactttatat tttctttaat cgtcttattc tcaccactaa
    19861 atttaattgg tgacgtccct gaaaattttt taaattcttt tataaagtgt gcttggtcat
    19921 agtactcatt ttcataaata aaatcaaaaa gttcatcatc tttataatta taaataagtt
    19981 gattgcttgc cattttaaat ctgtaaattc tctttaaaat cttaggtgta taccctgtat
    20041 attttaaaca gattctttcc aatgttttaa tatttatatt tgtatcatca caaaatgctt
    20101 ttatattgct atatctatta acatatataa atgaatttag aagctttaca tatttatttg
    20161 aaattaaatc ttcttctaat atggataata atacttcttc taaacataaa acaacttttt
    20221 ctattgcttt tgttggattt aatgactctt ctaatttttt tgcaaatagt tttgatactg
    20281 cttctaggtc aacaatttgt ctgttaaact ctgaaattgg tatctttaaa aatggataga
    20341 gaccaaatgg ataaaaagaa atccctataa cacgtatatt tccatgttga ataataaatc
    20401 catgtttatc ccttattcca ttaaaatgaa tattactagc aatatagtct tgattttcaa
    20461 ttttatattc cataacatca gaaagattga gaataatatc tatactgtct gtcggaagta
    20521 acttattatt taacagtata tttgattttg tctcaaaata ccaaataaac tttacccacg
    20581 gctttaaacg aacatttttg attgaatatc ttgtaactga taacattgtg aactaacctc
    20641 tatactaaaa ttttttaatt atgtactcca tcctaatatt atacagtata atttatgcta
    20701 tcataaattt tagttcactt tatatttatt ttatacattt tttcaatacc ttagaaatag
    20761 gaagcgctat tataagacct atcaatactt gcattaaatt acctggtatt gaagtaagag
    20821 gtactataaa attaccataa agtataactt ctgttacata atatccaaat agcatccaaa
    20881 ttgatgaaac acatattcct attacattga ttaaaaaatt attcccatta ttaccatttg
    20941 cccatgcaat ctttccaagt aaataaccca taactcctct aactataaag gtaaacggtg
    21001 cccataaagt ccacccagat atcaaatcaa aaagtgacat accaatagct cctgataaag
    21061 cacctttttt acttccaaat actattgctg atatgaacaa cattgcagtt cctaaatgca
    21121 caagcccacc atttatagat attggtaatc ttatgtttat aaatttagtt gcaataaata
    21181 ctaatgctat taatagtgag gtttccacca tgtctttcgt tgtaaatttt tgcttagctg
    21241 taacttccat actatatccc cctatctatt aaaaataata cttattaaat aaatttaaca
    21301 aatttccatt tcctttgaat cctaatgcac ttaaactttt atccaaaaca tttagtacat
    21361 gttctatttt atttagattt gcattctctc ccatatgacc tattcttaaa atagtatcca
    21421 tatattgatt tagtgatgtt gcaacaagtg tattataatt tttaagcata taatcagtaa
    21481 gttctaaagc tcctatactt tcaggaattt ttatagctgt gactgtatta gaatatcctt
    21541 cttctaaaaa tagttctaga ccatattcct caatagattt tctaacacta taagctatct
    21601 tttcatgtct atttaataca ttttctattc cttcttctaa tatattatca agtgctttat
    21661 caagccccat tatgtcactt attggcattg tataagggaa gtattttttt tcataatagc
    21721 cttcccatat atttaaatta caataaaaac ctattacatc agtttttcta ttttttatac
    21781 aattttttgc atcttgactt attccgacta tagtaagtcc tgctggtgca gaaatagctt
    21841 tttgtgaacc acctaatatt atatctattt tagattcatc tacacttaat ctttctccta
    21901 ccatacctgc tacagaatca actacagtta atattccata ttctttaagt aatggacata
    21961 ttttgcttac atcatttaat acgccagttg gagtatcaca atgcactact gttgcatatt
    22021 taaaattact atcctcatct aaaaatgctt tcaattcatc aatatctata cttttagtat
    22081 attcacttga aaaaagcaca tactccccac catacattgt tacaaaatct ttaaaacctt
    22141 ctccatatat accattgtca attacaagta ctctatctcc tttttctgta agtgatgcac
    22201 atgctgcttc aagacctaat attccttcac cactcaatat gtaaacatcg ttttttgttc
    22261 caattatatt accaaacttc tcgcatgtct ttttataaaa ttcaacaaaa tcaatatcta
    22321 tatctggatt tgttgttttt tctgctcttg ctaatcttac attttcccta gtttcagttg
    22381 gtcctggtgc ataattaatc ttcttattca tatatatcag ctcctattta ttttctatac
    22441 gattattata caaaattttc attttatatg gtacaatttt atactttttt agaattgtac
    22501 cggtacattt tctaacatga ataatatcag tatattagat atattattga ttacataata
    22561 aaatacagag caaacatctg cttaaattgt ttgctctgta ctatgcttta acctatttaa
    22621 ttatgaatct ctttaactat atttttttat atgttttttg ctagttaaac taaccataaa
    22681 tatttgtatt ttattcactg tatcttactc tatcaataag agattcttta ttaaaacttc
    22741 gtcctatcaa ataagttgtt ataaattgag ctataagaat acacacaatc atcaacaaga
    22801 ttggtactat tggcaaagaa tatgttgcat aagataatcc agtctttttt agaaatataa
    22861 cagcaatata ccctaatata cctccaaata gaatacttcc tatcatcatt ccagaagtgt
    22921 aatacattgc ctctgaatta agcattttca ctaattgttt attagtaaga ccaatagctt
    22981 gaagcatacc aagttctttt tttctagtaa ctatgctagt tatcattgtg ttgacaagat
    23041 tcataaatcc aatcacacct attatgcctg ttagcgtgta tcccattatc tttataaatg
    23101 aaatagtagc cttatttgac tcaattctac tatctataaa atcagtctct aaaaatccat
    23161 tatttttagc aatcttcttg atactatctt tgatttcttg atactttcct tcttctgtat
    23221 atattcccaa gctactagtt gaatcgtatt tcaaagttct atcaataaaa tccttcccta
    23281 taccaaaact tggaaccccc atagctattg cttgaacttt aaattctttt tttatctttt
    23341 tatctccatc atataaagtt aatcttattt tatctcctgc ttttactccc atttcttttg
    23401 ctgtatcaac atgagtaatt actatttcat ctccagtttg aagtctttca agatttattt
    23461 ttccatctat tatattcttg tttaatgatt ttacatcatt ttcatttata ctttgtaaaa
    23521 ggtcatactt aaattcaaca tcatagtcct ccataccaat ttttacactt cttgcagatt
    23581 ctattctttt aattccttcc atgttcttta tttgattaaa aaaatcttta cttagaggat
    23641 tatccatttg taaaatattc aaattatctt taggattttt atcactgttc atttcataac
    23701 cagatagtct aacttctata tcataaggaa agtgttctct tgccattttc tcagcatcaa
    23761 aactttctaa ggcagttgat actgttataa atatagttcc actaagtata agtgatgcca
    23821 atgtcatgta agtacgtttt ttatttcttt ctaaattggc atgtgataat ctctttagat
    23881 ttatattttt atatcctttt ctcttactct tattacttat tttatttcct gtatatctta
    23941 ctgcgtcaac aatggatact tttgatgcta ctttcattgg ttttaaaagt gataaaacaa
    24001 cagatataaa gcttattacc acaaccgata atataactgg taatcgtgat gattttacat
    24061 ctatatccat aaatgatttt attataatat ttgcaagtac atagcctaaa attattccta
    24121 ttggtattgc tattccggct aatatgaacc cttccttaaa tactatattt tttacttgtt
    24181 ttttagttgc accaattgct ctaagctttc caaattcttg aacctttgta actattgaaa
    24241 tataaaatat attgtatatt actaaaatac tagacaatac aattactaac cctacaaata
    24301 ctccacccat aattgtttcc atatctggtt ttaaagcatt tatatagttt tcatttacag
    24361 ctacattaat agtgtccaat cctacatcat tagcaatctt atttaatttt gattttgctt
    24421 gttctatcga taaattactt ttatcattta atttcacata tatattaaaa tcttcttgtg
    24481 acatatctct agtatttctc atatatgatt ctgatataat agcataataa tatttacctg
    24541 cttcagatat ttcgctagtt tttaagattc cacttataat gaactctttt tcaatttttt
    24601 tatcactttt atagtcatta taagatattt ttatcttttc acctaaatct ttatttttat
    24661 aaccaagtgc ctttaaagct ccactatcta acacaatttc attctctttt gatggcaatt
    24721 ttcctttgat aaattcaaaa ctatttaatt tcaaagcatc ttcattcatg tatgctagag
    24781 aaatatttga atcatcttcc agtttttcaa cacctactcc attcatttta ccagttaatt
    24841 caacatctgc atgattactc aatatatcag cttgtttttc gtctacattt gctaatatac
    24901 cttgataatt acctgaatac tttatagtat tttctttttg atatgctcct gcatcaacaa
    24961 tataaattcc aatagaagaa agcattaagg ttgaaagtat tatagtaatt attattagaa
    25021 tactttttga tttattttgc tttaaattac tttttgctat tttagtagta ttaatcattt
    25081 ttatcaccaa cctttgacac cctgccatct tctatgaata taactctatc agccatttgg
    25141 gctatactgt catcatgagt tatcataact agagtttgac tgtacttctt agacatagat
    25201 tttaatatac tcataacctc atcagatgtt ttagaatcta ggtttccagt tggttcatca
    25261 gcaagtatta tagctggtct tgtagctaat gctcttgcta ttgccaccct ttgttgttga
    25321 ccacctgata atgtatttgg taaaacgtcg tgtttatttt caagtcctaa tgattttaaa
    25381 agctctttta taaaaggttc atctacctct ctaccatcta aaccgattgg caacactaca
    25441 ttttcccata cattaagaga tggaattaaa ttatagcttt gaaatataaa ccctattttt
    25501 cttcttctaa atacagcaag ttcttcttct tttaatgtaa atatattttt attatctata
    25561 tacaccttcc cagatgtagg tatatcaaga cctccaatca tatgcaaaag tgtacttttt
    25621 ccagaacctg attttcctat tattgcaaca aattcacctt catttatttc taagtcaaca
    25681 ttgtccaaag ctcttactaa gctttctcct tttccataat gctttgataa attttcagta
    25741 tatagtattt tcataaaatt atcctctcat tctaagttat attactccat attttattaa
    25801 ttttttattt ctggagctgt ttatacttat ataataaatg tagaggctta cattttcctt
    25861 tcatttaata ttacatagtt gtaagaaaca aagaaaactt gctccctatt cctacttttg
    25921 aagaaactat aatatttcca ccttgttctt ctaaaatctt tctacttaaa tacaatccta
    25981 ccccactacc ttctacagat tcaatttcat cagcagaacc tctataaaaa cgtttaaata
    26041 tattattaaa ctcacttttt tcaatcccta tgccattatc ctctattata attttaaaga
    26101 aattagcagt ttcttctaca gatatattta tttctccatt tacctgtgta tactttacag
    26161 cattgtctaa tacattaaaa atactctcct cagtccactt tttatcatgt ggtataattc
    26221 tactgttaaa ttcatttaaa tttaatgtta tacttttgct cttagcctta ggggtaacac
    26281 tttttactgc atttagaata gtatttttta tatcattatc ttcttttttt atgtttatca
    26341 tgctaatttc taaccttgat atgttcacta aagaatttat taaattttct aatttattta
    26401 tagaagcctt attggttaat aagaactcgt tggcttcatc ttcttctaat tcttcttcta
    26461 taagtaatgt attgtataat tttaaggatg ctaaaggagt ttttaattga tgggaaatat
    26521 ctgttactaa tgattttaca ctttcttttt ctttttctaa tttaataaac tttatcttta
    26581 aacttctatt aagctcatat agacagttat ttatcttact aaatatgcct tctttaaagt
    26641 attcattata ttctactaga taaccagttt cttctgactc agtagtgtcc ttcaagtagt
    26701 tttcttgtga catcttatct actataaa
//
LOCUS       DAEHWM010000049        25983 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.050, whole genome shotgun sequence.
ACCESSION   DAEHWM010000049 DAEHWM010000000
VERSION     DAEHWM010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25983)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25983)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25983
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.050"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(305..2797)
                     /locus_tag="KNP36_002132"
     CDS             complement(305..2797)
                     /locus_tag="KNP36_002132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896283.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0874002.1"
                     /translation="MNHNTSIKNKDSNPKIFLVLTLYLLGIFMGAIDTGIVSPARTII
                     QNSLGVNEKTGIWMITIYTLTYASVIPISGKLADKIGRKYVYLVSIFLFGSGSLICGL
                     SSLFSNFYILLIGRVIQAIGGGGIMPIATAEFGTTFPENKRGMALGLVGATYGIANIL
                     GSSIGSTILSIFGTQNWKWLFFVNLPICLIILIGGVFCIKNNKSESKEKIDKLGTLML
                     ICIIVSLLYGLMNIDFFNFKNSIQDISVYPYLLTFIVLIPIFIFIENRAKDPILSFEY
                     FLNPRILIVLILSLIVGIGMMGMVFVPQYAENALKINAGSGGYFVAILGLFAGIAAPL
                     SGRLIDKFGAKKILLLGFSVSMIGSLYLVLIALKTNTVFSVCVSLIFMGLGMGFTMGT
                     PLNYMMLSNTRLEESNSALATLSLIRSIGTSISPAIMIGFIAHAGLSVQDNIMDLVGK
                     PSTPKIVQLEELENMIDDLKSDPEMAKNLKNVSIPNMNDTSNINMDMTGGKLPKSLLN
                     KVQSADTTNITNITKEISTTMFDEKVPSIITKIQKNVQKGIDGTQSGINGIEDGENKL
                     NSGIKGVQTGIDNMVKARAGINQGIDGVKKGIAGVDKGIKGMEQGLEKQDEAIKELTT
                     AYNKIPTTEKTPTDNENNSNEQNQSNTSNSESDDTKNDSTENKNNNSSENKPNVNEQK
                     ESLNAQIQQLKKTRDDLNTKLQKNKTQKNELSKKLRTMESQKKELQSKLNNSISQKKD
                     MEKSLDTMQQQKKSLQAVLAKTQEVKTEIPKAFDKSKLDYINSIENNRTKIENTLQST
                     LNSGFKQMYITVFCVNLLAFIILLFYKENKTR"
     gene            complement(2811..3353)
                     /locus_tag="KNP36_002133"
     CDS             complement(2811..3353)
                     /locus_tag="KNP36_002133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0874003.1"
                     /translation="MPKILENVKEDILKVSRDMILEEDYSNISIRKIAQRCGISAGTV
                     YNYFNSKQEIIEYITKSEWDLLIRRIEYSNKNTEDYIKKLNIIFTEIRNFINKVHNIQ
                     YNDFLNTFETERFFEMKKHKDDFHEQLSNKVYEALEKESFFNNDKLVCNIIIKMFFSY
                     STYLHIEFEDLKPYIEKLIH"
     gene            3597..5111
                     /gene="glpK"
                     /locus_tag="KNP36_002134"
     CDS             3597..5111
                     /gene="glpK"
                     /locus_tag="KNP36_002134"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HBF0874004.1"
                     /translation="MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGW
                     VEHDPMEIWGSQSGVMREVIETAGIRPEEIASIGITNQRETTVVWSRYTGKPIYNAIV
                     WQCRRTSEICDELKNKGLEESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGEL
                     LFGTIDTWLIWNLTRGKVHVTDYSNASRTMMYNINDLEWDEDILRELDIPISMLPLVK
                     PSSYVYGHTDERMLSGAKIPIAGCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTG
                     SNIVKSKHGLLTTIAWGVDGKVTYALEGSIFIGGASVQWLRDELKIIESAKDSEMYAN
                     RVEDTNGVYVVPAFTGLGAPYWDMYARGSILGLTRGAKKEHIVRATLESIAYQTKDVL
                     EAMQNDSKLKLKSLKVDGGASNNNFLMQFQSDILNVDIDRPKIVETTALGAAYLAGLS
                     VGFYIGRNEITSKWSVEKEFNPNMSEEKRCKLYKGWKKAVSRALSWEKEDELDI"
     gene            complement(5225..5854)
                     /locus_tag="KNP36_002135"
     CDS             complement(5225..5854)
                     /locus_tag="KNP36_002135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0874005.1"
                     /translation="MDKNYTMPIYQKIALDIANKIYTGEIQEDSVLFGRSVLAGKYNV
                     SPETIRRAVKILEDIGVVKSIKGKGVIVLSPDKASSFIKKYRDITNISSYKSTLYNLI
                     DTKSNLENEILDTINKILDYSNRLEIINPLVPVQFTINSNCKYIGQTAAQTKFWQNTG
                     ATIVAIKRGEELIISPGPYIEFLEGDILLVVGDQHIYNSIPMFLYENEK"
     gene            6442..7233
                     /locus_tag="KNP36_002136"
     CDS             6442..7233
                     /locus_tag="KNP36_002136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LamB/YcsF family protein"
                     /protein_id="HBF0874006.1"
                     /translation="MYKVDLNSDLGESFGTYKIGLDEEVLKYISSANIACGFHAGDPS
                     HMEKTVQLAKKNGVKIGAHPGFLDLIGFGRREMKITKQEAKDYTKYQLGALMAFASSN
                     GCNIQHVKPHGALYNMAAKDKELAMGICEAIYEVDKDIILLGLYNSEMINSAKEIGLR
                     FANEVFADRAYDNNGFLVPRNVEGAVIHDTKHAIDRVVRMVKEGTVETLTGEVIHIKA
                     DSICVHGDNPKAIEFVKEIRKRFELEGIEVCPLENIEVCSSENIV"
     gene            7262..8482
                     /locus_tag="KNP36_002137"
     CDS             7262..8482
                     /locus_tag="KNP36_002137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divalent metal cation transporter"
                     /protein_id="HBF0874007.1"
                     /translation="MSTKNITDKTKNKKDVGALIGAAFIMATSAIGPGFLTQTAQFTQ
                     DFGPNFSFVILITTILFIGAQVNVWRVIGVSGLRGQDIANKIIPGLGYLVAFLVALGG
                     LAFNIGNVGGAALGMNVMFNMNMTLGTVLSGLIAIFVFMSKNSNSLVDKITKFLALGM
                     IIIVGYVAISNHPPVGEAVSRMVKPENPKGLIFPIITLLGGSVGGYITFAGGHRLIDG
                     GITGEENIKEITKSSLLGILVATMMRVLLFLAILAVVSKGLQLDPENPAASAFKFSAG
                     AIGYKFFGLVLWSAAITSVIGAAYTSVSFLKTLNPFIDKYEKYFIIAFIAISTLIMAF
                     IGKPATLLILAGALNGLILPITLGIMLIASKRKDIVGDYKHPTWLLIFGLIVVLISAY
                     TGITSLSSLGALFA"
     gene            8502..9197
                     /gene="pxpB"
                     /locus_tag="KNP36_002138"
     CDS             8502..9197
                     /gene="pxpB"
                     /locus_tag="KNP36_002138"
                     /EC_number="3.5.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-oxoprolinase subunit PxpB"
                     /protein_id="HBF0874008.1"
                     /translation="METRYLISGDKAVVAEFGNEISEDINKKVISFMRAIEISNLKGI
                     VTEMVPTYRSLMISYNPLEIDFDSLIENLKKIEDNLESIVLPKPKIHEIPVCYDEVFG
                     IDIKNVASYNNLTVDEVIKIHTSREYLIYMLGFTPGFPYLGGMDERIATPRLEVPRTK
                     IYGGSVGIAGSQTGVYPIDSPGGWQIIGRTPLKLYDENREEQILLRAGDFIKFVPITL
                     DEFIEIEKNNLSI"
     gene            9227..10213
                     /locus_tag="KNP36_002139"
     CDS             9227..10213
                     /locus_tag="KNP36_002139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin-dependent carboxyltransferase"
                     /protein_id="HBF0874009.1"
                     /translation="MGFKVELGGFQTLIQDRGRVGYGQYGVSGCGAMDEYAHRVGNIL
                     VGNSEDEASLEVLMLGPTITFDEYTQIAVTGGDLGAKINGKEIQNWRSYQINPGDVLS
                     FRGVKSGTRAYVSIAGGIDVPLAMGSKSTYTRAKIGGFEGRALKKGDYINTFIQEKDF
                     TINKKLSSKYIPTYSSEIVLRIVKGPQFDAFSNGEVEKFLSNKYKVTNEIDRMGCRLD
                     GESIKHLNGADIISEGISYGAIQVPGHGKPIIMLSDRQTSGGYTKIGNVISVDLYKLA
                     QAKPNDVVKFELVDIYEAHRLLREQEDKIQDIYKSMKNIRVVKAKVLNDIAV"
     gene            complement(10427..10993)
                     /locus_tag="KNP36_002140"
     CDS             complement(10427..10993)
                     /locus_tag="KNP36_002140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874010.1"
                     /translation="MLGEKMRNIRKSKKKTLSDVSKLTDLSISYISQIERDAIEPSLS
                     SLRKIAEVLDTPLYMFMDDNNTDDLVIRKEDRVMMKFPKSEMFYEIVSPMPTTEFTPS
                     ILFVEFELKPESEDAKDYIYHASEEIMVVTSGVVDICMGEKVVRLNPGDSTFIKANVP
                     HKIINPSKDTIARGYGVISPPIWPIKSK"
     gene            11345..12412
                     /locus_tag="KNP36_002141"
     CDS             11345..12412
                     /locus_tag="KNP36_002141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptide epimerase"
                     /protein_id="HBF0874011.1"
                     /translation="MKITDIKFEKLRIKLKKPVVVSFGVIEYGESIILKIETDEGYCG
                     FGEAAPLAAVTGEVLDNVLSVLLMFKKELIGKDPLDIETIHTIMDGIIIGNTSAKAAI
                     DIALYDIKGKIMNAPLYKVLGGFDSKVQTDITISIDKPEKMAVEALERVKEGFRILKL
                     KAGINPEDDIEAVKLIREAVGESIRIRIDANQGWNVNSSINTIKKLEEFNVDAIEQAL
                     PHWDLDGTAYIRNKSNTKIMIDESLHSPIDAIKAIKKNAVDTFNIKLMKSSGIYPAIK
                     INNIAEASGVNCMLGCMLETRIGITAAANLIASKKNITEADLDSFMFCEELEGISGGF
                     VMDGDIMNLVNKPGLGIEVNL"
     gene            12431..13591
                     /locus_tag="KNP36_002142"
     CDS             12431..13591
                     /locus_tag="KNP36_002142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 family protein"
                     /protein_id="HBF0874012.1"
                     /translation="MNTLFSNPGSILAVMTSMIALGFYLQRYKAIKSLGPALTIIIMG
                     IILSNLKVVPVSTELYGTISTYAIPVSMTIMLMSVDLKEMTKLSREPLIAIFVAVLTV
                     SIMAFLFGLVFAEKISEGWKVAGMFVGTYTGGSANLTAIGTGLNVSRQTLAAANAADY
                     VIGVPTLIFMFALPAILKNSKKFKKLWPYHVEESELEDCQNEEFMESKEWSIKDIAWM
                     LAIGFVVTEVATILAGYFNSSFSSAARILLVTTISIIIAQLKPVKKLKGNLDLGLFVA
                     LFFLCTIGFSVDIKEFLGSTFTITLYCFSIIFASFVFHLGITRLLKIKYQYVILSIVG
                     AIADGPTSALVAASAKWNSLVSVAVVMGVIGGVLGNYAGISVAYAIKMSLGL"
     gene            13604..15700
                     /locus_tag="KNP36_002143"
     CDS             13604..15700
                     /locus_tag="KNP36_002143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CocE/NonD family hydrolase"
                     /protein_id="HBF0874013.1"
                     /translation="MIKFKLYISGLYSGNVIFDGDLLIEKLNPFTNKIESLKPISKEE
                     NTYYLNLTKIDLKSLFNNFDVYTKSLVNTDKDTVINNLGETHSKLNEYIWVQRNKKFP
                     LDIIIVDNKIVGFICLSRETCTILIMDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMI
                     DMKDGIKLSTDVYLPDFVDSTKKAPTILMRTPYGKENDKEIYYKYVQRGYAVVIQDVR
                     GRNESEGKWEPMIHEREDGDSTINWIVSQEWSSGIVGMLGASYLGYVQWAAASSGNKH
                     LKALVSIVTSGSPFIDIPRKGGAFVSGMLAWAFMVSRNKVDRSKMVRDDWDDVLNIRP
                     IENIPVEALGYRIEFLEEWLKRVEKDEYWDLMDWHLQKDKINVPALVVSGWYDDNSMG
                     TTEALDVIKDYEKGKRKAILGPWMHNSNTLRDINGISLGNSSLRYDLDYNYLLWFDKY
                     LKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKIDKSMYLISDGNANTSLGNGRLV
                     FDNGLEEKYDSYIYNPKDPSVQLIDMSENEVGVPNNYKDLEKRSDMLCYTSDAFSEEF
                     TVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGILSARFRNSFYKSEFMEE
                     GEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTEGYNSIEYIEAKNTIY
                     HGGKYPSKLILPIENK"
     gene            complement(15859..16203)
                     /locus_tag="KNP36_002144"
     CDS             complement(15859..16203)
                     /locus_tag="KNP36_002144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HBF0874014.1"
                     /translation="MEIKRYEGTGRMSRAVVHNNTVYLCGQTHAEGGVIEQTTEVLAK
                     IEDLLNKYGSDKQHLLSVTIYLRDMKDFEAMNSVWDAWVEKGFEPARACVEARLAREH
                     LLVEMSVVAATK"
     gene            16495..17385
                     /locus_tag="KNP36_002145"
     CDS             16495..17385
                     /locus_tag="KNP36_002145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBF0874015.1"
                     /translation="MSSTIKSNRIKGIMFIIASALGFAMMSAFVKLAGDLPSFQKVFF
                     RNLVSAIIAFWLIIKHKGSLTGKKENLKVLLYRSIFGTLGVIFNYYAIDKLMLSDANM
                     LNKMSPFLVVIFCAIALKEKINVKQIGAIIIAFIGALFIIKPTFSVEIIPYLGGIAGA
                     VFAAMAYTCLRVLGDREDYYTIVFFFSVFSLVTVGPIAFAVYEPMTLMQLIYLLLGGV
                     FASLGQFGITLAYKYAPAKEISIFDYSNIIFSAILSIFLFNVYPDMLSVVGYLIVFSA
                     AFYMFLYNKKLDKLDKEKKK"
     gene            17603..18889
                     /locus_tag="KNP36_002146"
     CDS             17603..18889
                     /locus_tag="KNP36_002146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBF0874016.1"
                     /translation="MEKVKVAVIGAGNRGTYAYAPYIYENSDVCEIVAVAEPKKGRRE
                     LFTQKYNLDSKNVFETLEDFFKHDKMADAVIIATNDDRHYDVAKLALEKGYHVLLEKP
                     MSNSLDGLVHIDDLCDKYKDKIFMICHVLRYSPFYNKLKEIVESKKLGELVSIQYNEN
                     IGYWHFAHSFTRGNWRNSNETSPLILAKSCHDMDILLYLVGSRCKKISAFGSLKHLNN
                     QNASGEMAQNCLQCLVEKKCPYSAKRIYLEKDRSINRAVHINPTEENLLNILKTSPYG
                     RCVYRCDNNVVDNMVNILQFENGVTATFNLCAFTKENGRTIKLMFSHGEVGGDLNKNE
                     IRIKEFGKNEEIVMNPSNQQNMVEEYDRNLIAEFIKLVSNKELEKGRVAAKEAIQSHV
                     MAFAAEYSRVSDEVVYIEEFFDSAKQMTKEIEETIF"
     gene            complement(18978..19421)
                     /locus_tag="KNP36_002147"
     CDS             complement(18978..19421)
                     /locus_tag="KNP36_002147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="regulatory YrvL family protein"
                     /protein_id="HBF0874017.1"
                     /translation="MIKISNKRRIPLGEFISVFLFFAVFFGITFCIFTVIGIGFLSFL
                     GFEYKSLGAVLIFFLIYFCITTPIDFLCTTILDIFRYVNKLPYSIYKLCEFIIDFILT
                     FLAMNIIDTFMDSVTIPLSTEILFALLSYLLSECMDFFDRDKKKP"
     gene            complement(19445..20239)
                     /locus_tag="KNP36_002148"
     CDS             complement(19445..20239)
                     /locus_tag="KNP36_002148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M55 family metallopeptidase"
                     /protein_id="HBF0874018.1"
                     /translation="MKLYLSADIEGTCGIVNWDETKLECEFSQHYRTQMSKEITAACD
                     GATQSGVHEILVKDAHDSGRNINPNILPENVKILRGWTKDPLVMMAGIDESFDACIFT
                     GYHSGATCNGNPLSHTMDIDYDYFKINDEIASEFTINAYIAAYYNVPVAFLSGDEMLC
                     ESAKKLNPNIVTVPVSKGIGNGSISIHPNLALKKIEKGVKKALSGDLSRHLIKLPDKF
                     KIEIKFREHYKAFKASFYPNMKKIDSQTVLFETEDYYEFLRMLLFI"
     gene            complement(20804..21280)
                     /locus_tag="KNP36_002149"
     CDS             complement(20804..21280)
                     /locus_tag="KNP36_002149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HBF0874019.1"
                     /translation="MKEILINPIGKICIQGEEVFIKLDKKYVPALNELDDFSHLNVFW
                     WADGFDNPELRSILETPKPYKSGPDVIGIFATRSPIRPNPIALTAVQIINIDHENGII
                     KIPYIDANDNSPVIDLKPYTPSVDRVENPSIPKWCSHWPKSVEKSGEFNWEDEIEF"
     gene            complement(21381..22550)
                     /locus_tag="KNP36_002150"
     CDS             complement(21381..22550)
                     /locus_tag="KNP36_002150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0874020.1"
                     /translation="MLNIKTLCHEINDWVINIRRDLHKTPELGLEEFQTKKKIIKYLN
                     EIGINYIEYKNHTGITAYINVSPNFETVAIRADIDALPITEELNYSYKSINIGKMHAC
                     GHDAHTAILLGTCNILFKLKDYLNVNVKFFFQPAEETIGGAQLMIEDGCLENPNVKYI
                     FGLHVNSNINKNLIELKYNTLNASTDTLQLTVHGSKCHGAYPHQGIDAIVISAHIITA
                     LQTIVSRNTNPTDSVVISLGKIEGGIKENIVCDKVVIRGTLRTLTPETREFSKKRIRE
                     ICDFTCKTFGGSISVEIEEGYPALINSNHLVDYVKQNAVELFGEENIILKDSPTLGAE
                     DFSYFLRHCEGAFYHLGCANREKNITSPLHTSTFDIDEDCLITGVMLHVKNVLSF"
     gene            22713..23576
                     /locus_tag="KNP36_002151"
     CDS             22713..23576
                     /locus_tag="KNP36_002151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
                     /protein_id="HBF0874021.1"
                     /translation="MLGIIAPSGPLRNTSLEEIKFNLESYGYEVKFSESCSLNYKGYL
                     AGNDDIRARDIEDMFLDKDVDIIMCLRGGYGTTRILDKINYDIIKQNPKPFIGFSDIT
                     GLNLAFYKNCGLLPYHGIMAANVGKWDKFTYKSLVNALEFKDELYLENPKEEKIYTVC
                     EGKAEGIIMGGNLSLIIATMGTKYEIDAKDKILFIEEIGEPQYKLDRMLTQLYSSGKL
                     EECNGIIFGDFKDCIEENDLMELLIEFANKVNKPSIYNLQSGHCIPMITIPLGRMCEL
                     DATEKIVKLKK"
     gene            23647..24240
                     /locus_tag="KNP36_002152"
     CDS             23647..24240
                     /locus_tag="KNP36_002152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3867 domain-containing protein"
                     /protein_id="HBF0874022.1"
                     /translation="MSDDRIIDFNELKNKVKDSDVDKFEQYIYNLYFSVMDGKMSMAE
                     FSRKIFDYMRDNNISQEKFMKIQKQFMERYGMDTEEVEKQLRNFGIDPSTAGFMSNNT
                     SSKVSTEDLESFKKSAGFYEKYGEKIQPKSCITTFIKNDLNDINVIIDQEKIMLCSDR
                     KINLMDSELNEFLLEYKNMFNKKIKVVMCETTNKYDY"
     gene            complement(24491..25126)
                     /locus_tag="KNP36_002153"
     CDS             complement(24491..25126)
                     /locus_tag="KNP36_002153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBF0874023.1"
                     /translation="MDNLLNELEALKSNLDNLPIEKIENYDLSKTALFIIDVNNGFAR
                     QGALYSPRVESLIKPIEMFTKKISNKLNRVIAFTDSHTPKSIELLSYPVHCLENDVES
                     ELVDELKSIENLQILPKNSTNGFFALENLDFDNIDNIIIVGDCTDICIYQFAITLKSY
                     FNQHNIEKNIVVPMNLVDTYDIPNVHPAEILNLVFFNSMIQNGVNVLKEIR"
     gene            complement(25206..25937)
                     /locus_tag="KNP36_002154"
     CDS             complement(25206..25937)
                     /locus_tag="KNP36_002154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HBF0874024.1"
                     /translation="MNIYAHRGFSGKYPENTILAFKKCLDMDIYGIELDVHRTKDGKI
                     VVIHDEKVDRTFNGHGFVKDFTLRKLKTLNSSFEGYQSNKECKIPTLEEVLILISPTD
                     LTLNIELKTDKINYPNIEKGVLELILKYNMKNRVLISSFNSNSLKNFHKLDPSVKTGL
                     LCYLPINNVVNFAKFLGNSYLHPPLVLVNESLIELCHKNLLGVNVYTVNEEDDILHCL
                     KLNVDGIFTNYPDIASNLLHSKQYS"
BASE COUNT         9655 a         3141 c         4242 g         8945 t
ORIGIN      
        1 aatatgctca taatatgatt ttaacatatt atagttgaaa atatatggtt tattttgatt
       61 tgtatatata acaataggtt taattgttat ataaatgtaa aggggtgtat gaatagattg
      121 tataaattta tttcgataaa ctaagattgc tttttgattg tctgtaaaag agaaaaagat
      181 taagagaaaa atagtattat attgtaattt atattaatca attacaaaaa ttttatgaat
      241 ttattcttta gaataaaata tttaagaata agataaattt acaatataat actataacac
      301 tcttttatct agttttattt tctttataga acaataatat tataaatgct agtagattta
      361 cacagaatac tgttatatac atctgtttaa atcctgagtt tagagtagat tgtagtgtgt
      421 tttctatttt tgttctatta ttttctatgg aatttatata atccaatttt gatttatcaa
      481 aagcctttgg tatttcagtt tttacctctt gtgtctttgc taaaactgct tggagtgatt
      541 ttttttgctg ttgcattgta tcaaggcttt tttccatgtc tttcttttgg cttatagaat
      601 tatttaactt gctttgtagc tctttctttt gagattccat tgttcttagt tttttactta
      661 attcgttctt ttgagtttta tttttttgta actttgtatt taagtcatct cttgtctttt
      721 ttagttgctg tatttgagca tttaaacttt ctttttgttc atttacattt ggtttattct
      781 cgctggaatt gttattctta ttttctgtag aatcattctt agtgtcgtct gattcagaat
      841 tactggtatt actctggttt tgttcatttg agttattttc gttatcagta ggagtttttt
      901 ctgtagtagg tattttatta taagcagttg taagttcctt gatggcctca tcttgttttt
      961 caagaccttg ttccatacct tttatacctt tatcaacacc agcaatacct ttttttacac
     1021 catctattcc ttgattaata ccagctctag cttttaccat attgtcaata ccagtttgaa
     1081 ctcctttaat accactattt agtttatttt caccatcttc aataccgttt attccacttt
     1141 gtgttccatc tattcctttt tgtacatttt tctgtatttt agtaattata gatggaactt
     1201 tttcatcaaa cattgttgtt gatatttctt ttgttatatt ggtaatgttg gttgtatctg
     1261 ctgactgaac tttattaagt aaggattttg gaagtttgcc acctgtcatg tccatattta
     1321 tatttgaagt atcattcata tttgggatag agacattttt taaatttttt gccatttcag
     1381 ggtctgattt taagtcatct atcatgtttt caagttcttc aagttgaact attttaggag
     1441 ttgagggctt tccaactaag tccataatat tatcttgcac agataatcct gcatgtgcta
     1501 taaatccaat cattatagct ggagaaattg aagtaccaat tgagcgtatc aaggataatg
     1561 ttgcaagtgc tgaattagat tcttctaatc ttgtatttga taacatcata tagtttagag
     1621 gagttcccat agtaaatccc attcctaatc ccataaatat taaacttaca catacactaa
     1681 atacagtatt ggtttttaga gcaattaaaa ctaggtaaag agagcctatc atagatacag
     1741 aaaatcctag taatagtatt ttttttgccc caaacttgtc aataagtctt ccgcttaaag
     1801 gagcagcaat acctgcaaat aatcccaata tagctacaaa atatccccca gaaccagcat
     1861 ttatctttaa tgcattttca gcatactgtg gaacgaatac catacccatc attccaatac
     1921 caacaattaa agataaaata agtactatca atattctcgg atttaaaaaa tattcaaagc
     1981 ttaaaatagg gtctttagct ctattttcaa taaatatgaa aataggtata agtacaataa
     2041 atgtcaataa gtatggataa actgatatat cttgtataga atttttaaaa ttaaaaaagt
     2101 ctatattcat aagaccatat aatagtgata cgattataca tatcaacatc aatgtaccaa
     2161 gcttatctat tttttcttta gattcagact tattgttttt aatacagaaa actccaccaa
     2221 taagtatgat taaacaaatt ggaagattta caaaaaatag ccacttccaa ttttgagttc
     2281 caaagatact tagaattgtg ctaccaatgc ttgaacctaa aatattggca ataccatatg
     2341 ttgccccaac taaacctaaa gccatgcctc ttttattttc tgggaaggta gttccaaatt
     2401 ctgctgtagc aattggcatg attccaccac caccaattgc ttgaataaca cgaccaatta
     2461 ataaaatata gaaattggaa aatagtgatg ataatccaca tattaatgaa ccactaccaa
     2521 atagaaatat actaactaga tacacatatt ttcttcctat tttatctgct aattttccag
     2581 agataggaat tacagaagcg tatgttaatg tgtatatggt aatcatccaa attcccgttt
     2641 tttcatttac tccaaggcta ttttgtataa tcgttcttgc tggtgatact attccagtat
     2701 caatagctcc cataaatata cctaatagat aaagcgtaag tactaaaaat atttttggat
     2761 tactgtcctt gttcttaata ctagtattat gattcaaggt aaacaccacc ttaatgtatt
     2821 aatttttcaa tatagggttt taaatcttca aattctatat gaagatatgt tgaatatgaa
     2881 aaaaacattt ttattatgat attgcatact aatttgtcat tattaaaaaa actttctttt
     2941 tctaaagctt catatacttt atttgaaagc tgttcatgaa agtcgtcttt gtgttttttc
     3001 atttcaaaaa atctctctgt ttcaaaagtg tttaaaaagt cattgtattg gatattatga
     3061 actttgttta taaaatttct tatttcagta aaaataatgt ttagtttttt tatgtaatct
     3121 tcagtgtttt tattggagta ttcaattcgc cttatcaata aatcccattc agattttgtg
     3181 atatattcta ttatttcttg ttttgaatta aagtaattat acactgtacc tgcacttata
     3241 ccacaccttt gagctatttt ccttatgcta atattcgagt aatcttcttc taaaatcata
     3301 tcccgagaca cttttaatat atcttctttt acattttcta aaatctttgg catattacca
     3361 cctcttttat taaaattatt atgaacactg tttattatac tcctttaaaa tttattaatc
     3421 aatatgtaag ctataatgta taatattatt atatagatat gatagaaaat aagtgtcttc
     3481 ttactaaata tctattatat taaatttgta cttaagtatg attatttatt gaaatatgtg
     3541 atattaaatt tttcttttta ataaattaaa tattatatga taaggagaat atggtgatgg
     3601 aaaagaagta tgtaatggca ttagaccaag gaacaaccag ttcaagagct atactattta
     3661 ataaaaaagg cgaaatagtg aaaattgcac aaaaagagtt caatcaaatt tatccaaaag
     3721 ctggatgggt agagcatgac cctatggaaa tatgggggtc acaaagtggg gtaatgagag
     3781 aagttataga aacagcaggt ataagaccag aagaaattgc ttcaataggg ataactaatc
     3841 aaagagagac tacggttgtt tggagtaggt atactggtaa acctatttat aacgcaatag
     3901 tatggcagtg taggagaacg tcagaaatat gtgatgaact taaaaataaa ggattggaag
     3961 aatcaataaa agaaaaaaca ggtcttttaa tagatgcata cttttcagca acaaaagtaa
     4021 aatggatatt agataatgta gaaggagcta gggaaaaagc agaacaagga gagttattat
     4081 ttggaactat agatacatgg ttaatatgga atttaactcg tggaaaagta catgtaacag
     4141 attactcaaa tgcatctaga acaatgatgt acaatataaa tgatttagaa tgggatgagg
     4201 atatattacg agaattggac ataccaataa gcatgttgcc attagtaaaa ccttctagct
     4261 atgtttatgg tcatacagat gagcgcatgt tatcaggagc taaaatacct attgcgggat
     4321 gtgctggaga ccaacaagca gcattatttg gtcaaaattg tgttgaagaa ggtactgcaa
     4381 aaaatactta tggaacgggt tgtttcttgc ttatgaatac aggcagtaac atagttaaat
     4441 ctaagcatgg gttacttaca acaattgctt ggggagttga tggaaaagta acatatgcat
     4501 tagaaggaag tatatttatt ggaggagcat ctgttcaatg gcttagagat gaattaaaga
     4561 taattgaatc tgcaaaagat agtgaaatgt atgcaaatag ggtagaggat actaatggtg
     4621 tatatgtagt gccagcattt acaggtcttg gagctccata ttgggatatg tatgctaggg
     4681 gttcaatttt aggacttaca agaggagcaa aaaaagaaca tatagtaaga gccacattgg
     4741 aatcaattgc ttatcagaca aaggatgttt tagaagcaat gcaaaacgat tcaaaattaa
     4801 aactaaaatc attaaaagtt gatggtggag caagtaataa taatttttta atgcaatttc
     4861 aatcagatat attaaatgta gatatagata gacccaaaat agtagaaact acagctttag
     4921 gagctgctta tttagcaggg ttgtctgttg gattctatat tggaagaaat gaaattactt
     4981 caaagtggtc agtagaaaaa gagtttaatc caaatatgag tgaagagaag agatgtaaat
     5041 tatataaagg atggaaaaaa gctgtatcga gagctttaag ctgggaaaaa gaagatgaat
     5101 tggatattta aaaattaatc aaagttaaat ttatttgaat ttaaaaagag ctttatgtaa
     5161 aatatgaagc tctttttttg ttgttaatct tgcattttta tataatcaca ctaaattata
     5221 taatttattt ttcgttttca tataaaaaca ttggtataga attgtaaatg tgttggtcac
     5281 caactactaa gagaatgtct ccttctaaaa attcaatata tggtccagga gatattataa
     5341 gttcttcacc tcttttaatt gcaactattg tagcacctgt attttgccaa aatttagttt
     5401 gtgcagctgt ttgaccaata tatttgcaat tagaatttat ggtgaactga acgggcacta
     5461 aaggattgat tatttcaagt ctgttagaat agtctaaaat tttatttata gtatctaata
     5521 tttcattttc taaattagat ttagtatcta ttaaattata aagtgttgat ttatatgatg
     5581 atatatttgt aatatctcta tattttttta taaaagaaga agctttgtct ggagatagta
     5641 caataacacc tttacccttt atgcttttaa caacgccaat gtcctctaaa attttgacag
     5701 ctcttcttat cgtttctgga gatacattgt atttaccagc caaaacagag cgtccaaata
     5761 gtactgaatc ctcttgtatt tcacccgtgt atattttatt tgcaatatcc aacgctattt
     5821 tttggtatat tggcatcgta tagtttttat ccattgtttt tcccccaata caaaatttat
     5881 gttaaaaaaa tatataatct taacaatact attgtataat ttataggttt atatgtctac
     5941 aatatgtaca aatattgtgc atgttttaaa ataatatttt aacatgcatt tagtatacat
     6001 gattttatta tacttaaaac tatataaaga attaattata aaaatataaa gatattttac
     6061 ttacaaagaa tgataattat atagatgaaa gaaacaaatg aatgaagaaa aatgattctg
     6121 tcttgcatat aaagtgatta aaaatgaaaa atactttaaa aatgaaggtt aaagccctta
     6181 ttttaagtga aaataattaa ttattaacta aaaaatggta aaaagatttt ttgaaaaaga
     6241 aatacaaatg aatgttcaat taaaataatt gcaaaaatat tccttaaatg gtaaaattat
     6301 attaattaaa tgcaatagaa tagttgcaaa aataaaattg aatacaagtg ataaaatatt
     6361 tcatgcaata tataaaataa acaaaattta aaaattaaaa ctacttattc tatcaaaatg
     6421 ttagcgagga ggggtcataa attgtataaa gtagatttaa atagtgattt aggagaaagt
     6481 tttggaacgt ataagattgg tttagatgaa gaagttttaa aatatatttc atcagccaat
     6541 atagcttgtg ggtttcatgc aggtgaccct agtcatatgg aaaaaacagt acagctagct
     6601 aaaaaaaatg gagtgaaaat aggcgcacat ccaggtttcc tagatttaat aggatttgga
     6661 agacgtgaga tgaaaataac aaagcaggaa gctaaagatt atacaaaata tcaactgggt
     6721 gctttaatgg catttgcaag ttcaaatgga tgtaatatac aacatgtaaa accacatgga
     6781 gcattataca atatggcagc taaagataaa gagttagcta tggggatttg tgaagctata
     6841 tatgaagtcg ataaagatat tatactgttg gggctatata atagtgaaat gataaattct
     6901 gctaaagaaa ttggacttag gtttgcaaat gaagtatttg cagatagagc ttatgataat
     6961 aatggttttt tggttccaag aaatgtagaa ggagcagtta tacatgatac aaaacatgca
     7021 atagataggg ttgttaggat ggtaaaagaa ggaactgtag aaactttaac aggtgaagtt
     7081 atacatatca aagcagattc tatatgtgta catggggaca atccaaaagc aatagagttt
     7141 gtcaaagaaa taagaaagcg ttttgaatta gaaggtatag aagtttgtcc attagaaaac
     7201 atagaagttt gttcgtcaga gaacatagta taagactgat aacatgaggg ggagataaaa
     7261 tatgagtaca aaaaatatta cagataaaac taaaaataaa aaagatgtcg gagcacttat
     7321 aggggctgca tttataatgg caacatcagc aattggacca gggtttttaa ctcagactgc
     7381 acaatttacc caagattttg gaccgaattt ttcatttgta attttaatta caacaatcct
     7441 ttttataggg gctcaagtaa atgtatggag agtaattggt gtatcaggac ttagaggtca
     7501 ggatatagca aataaaataa tacctggatt aggctattta gtagcttttt tagtagctct
     7561 tggaggatta gcttttaata taggaaatgt tggtggagct gcacttggta tgaatgtaat
     7621 gtttaatatg aatatgacat taggaactgt attaagtgga ttaatagcta tatttgtatt
     7681 tatgtcaaaa aattcaaatt ctctagtcga taagataact aaatttttag cattaggaat
     7741 gataattata gttggatatg tagcaatatc aaatcatcct cctgttggag aggcagtatc
     7801 aagaatggta aaaccagaaa atccaaaagg actgatattc ccaataataa ctttacttgg
     7861 aggaagtgtt ggaggttata taacttttgc tggaggacat agattaatag acggtggaat
     7921 aacaggagaa gaaaatataa aagaaataac taaatcttct cttttgggta tattagttgc
     7981 cacaatgatg agagttcttt tatttttagc aatactggca gtggtttcaa aaggtcttca
     8041 acttgaccca gaaaatccag cagcttcagc ttttaaattt agtgcaggag caataggata
     8101 taaattcttt ggacttgtat tatggtctgc tgcaattaca tcagttatag gagctgctta
     8161 tacatcagtt tctttcttaa agacactaaa tccttttata gataaatatg aaaaatattt
     8221 tataatagca tttatagcaa tatcaacact tataatggca tttataggaa aaccagctac
     8281 tttattaatt ttagcaggag ctttaaatgg attgatactt ccaatcacat taggaattat
     8341 gcttatagca tctaaaagaa aagatattgt tggagattac aagcatccta catggctttt
     8401 aatatttgga ttaatagtag ttttaatatc tgcatataca ggaataactt ctcttagcag
     8461 cctaggtgct ttatttgctt aatttagaag aggtgacatt tatggaaact agatacttga
     8521 tatcagggga taaggcagtg gttgctgaat ttggaaatga gatatcagaa gatataaaca
     8581 aaaaagtaat ttcatttatg agagcaatag aaatatcgaa tcttaaaggt attgtaacag
     8641 aaatggtacc aacatatagg tcacttatga taagttataa tccattagaa atagattttg
     8701 atagtttgat tgagaattta aaaaaaatag aagataattt ggaaagtata gtattaccaa
     8761 aacctaaaat acatgagatt ccagtatgtt atgatgaggt ttttggtata gatattaaaa
     8821 acgttgcaag ctacaataat ctcactgtag atgaagttat aaaaatacac acaagcagag
     8881 agtacttgat atatatgcta gggtttactc ctggatttcc atatctaggt ggtatggatg
     8941 aaagaatagc tacacctaga ttagaagtgc caagaactaa aatttatggt gggagtgttg
     9001 gaatagcagg ttcccagact ggtgtatatc ctattgatag tcctggtgga tggcaaataa
     9061 ttggtaggac acctttaaaa ttatatgatg aaaatagaga agaacagatt ttgcttagag
     9121 ctggagactt tataaaattt gttccaataa cattagatga atttatagaa atcgaaaaaa
     9181 ataacttaag tatttaaata tcgttatagt acagggagtg gtatatatgg gattcaaagt
     9241 tgaattagga ggtttccaaa cattaataca agacagaggt agagttggct atggtcaata
     9301 tggtgtatct ggatgtggag caatggatga gtatgcacat agagtaggaa atatattagt
     9361 aggaaattct gaagatgagg cttctttaga agttttaatg ttaggtccta caattacctt
     9421 tgatgaatat acgcaaatag cagtaactgg gggagattta ggggctaaaa taaatggaaa
     9481 agaaattcaa aactggaggt catatcaaat aaatccaggt gatgtattat catttagagg
     9541 tgtgaaatca ggtactagag cctatgtgtc aatagctggt ggaatagatg ttccacttgc
     9601 aatgggaagt aagtcaactt atacaagagc taaaattggt ggatttgaag gtagagcact
     9661 taaaaaaggc gattatataa atacttttat tcaggaaaaa gattttacaa taaataaaaa
     9721 attaagttca aaatatattc caacttatag ttcagaaatc gtactaagaa ttgtaaaagg
     9781 tcctcaattt gatgcttttt ctaacggtga agtagagaaa tttttatcaa ataaatacaa
     9841 agttacgaat gaaatagata gaatgggttg tagactagat ggagagagta taaagcacct
     9901 taatggagca gatattatat ctgagggtat ttcttatgga gctatacaag tacctggtca
     9961 tggaaaacct attataatgt tatcagatag acagactagt ggtggctata ctaagatagg
    10021 gaacgttata agtgtagatt tgtataagtt agcacaagca aagccaaatg atgtagtaaa
    10081 atttgaactt gtagatatat atgaagcaca tagactattg agagagcaag aagataagat
    10141 tcaagatatc tacaagagta tgaaaaatat aagagttgta aaggcaaaag tattaaatga
    10201 tatagcagtt taattttaac aaatacaatt tttattatag tttataatat aacttacaaa
    10261 tagctattta ctatttacca taattaagat ggtttagatt agtcaaatag ctattttttt
    10321 agtttgagta aatattttaa atttaaataa atacttcaat tttaaaataa aagcaatatt
    10381 taaatctatt atattatcta caaaaagtag gtgtgtcata ttgagtttat ttagatttta
    10441 ttggccaaat tggaggtgat ataactccat atccacgagc tattgtatct ttacttggat
    10501 tgatgatttt atgtggtaca ttagctttta taaatgttga gtcacctgga tttaatctaa
    10561 ctaccttttc acccatacaa atatcaacca caccactcgt taccaccata atttcttctg
    10621 atgcatgata tatataatct ttggcatcct cactttctgg tttaagttca aactctacaa
    10681 ataaaattga aggtgtaaac tcagttgtag gcattggaga tactatctcg taaaacattt
    10741 cactctttgg aaatttcatc ataactctat cttcttttct aatgactaaa tcatcagtat
    10801 tattgtcatc cataaacata tataaaggag tgtctaaaac ttcagcgatt tttctcaatg
    10861 aagacaagga tggttcaata gcatctcttt ctatttgaga gatataactt atagataaat
    10921 ctgtcaattt ggaaacatca cttaatgttt ttttcttgct ttttcttata tttctcatct
    10981 tttcacctag cataagaacc tccaaataat aaaattaata taaaatattc gcttaaaaca
    11041 aagtaattat agcacaacat agaagtagtg gcaataagaa tacatagtag attttgacaa
    11101 ttaaaattta attaaatcca aataaaagtc tatgaaaatg aattattgtt aaattaatac
    11161 aaagaaaata ataataaaaa aatttaatag aagagtatta attgaattaa gattatcaca
    11221 ttatattttg gaaaagagta aattttcagt aaattatctt gacatatata ttgaagtaat
    11281 aatataattt aaagtataaa attttaaaaa ttgaattata acttcaaaaa ataaggaggg
    11341 taatatgaag ataacagata tcaaatttga aaagcttaga attaaattaa aaaaacctgt
    11401 agtagtttca tttggagtaa ttgaatatgg agaaagtata attttaaaaa ttgaaactga
    11461 tgaagggtat tgtggatttg gcgaagcagc gcctcttgca gcagttacag gtgaagtttt
    11521 ggataatgtt ctttcagtat tgcttatgtt taaaaaagag ttaataggca aagacccact
    11581 agatattgaa accatacata caatcatgga tggaattatt ataggtaata cttctgcaaa
    11641 agcagctatt gacatagctt tatatgatat taaaggaaaa attatgaatg caccccttta
    11701 taaagttctt ggaggatttg atagtaaagt ccaaacggat attactataa gtatagataa
    11761 gccagaaaaa atggcagtag aagctttaga aagagtaaaa gaaggtttta ggatattgaa
    11821 gcttaaagca ggtataaatc ctgaagacga tattgaagct gtaaagttaa ttagagaagc
    11881 cgttggagag agtataagaa ttagaattga tgcaaatcaa ggatggaacg taaatagcag
    11941 tataaatact atcaaaaagt tagaagaatt taatgttgat gcaattgaac aagcacttcc
    12001 acattgggat ttagatggta ctgcttacat aagaaataaa agtaatacaa aaattatgat
    12061 agatgaatca ttacattcac caatagatgc aattaaggct ataaaaaaga atgcagttga
    12121 tacatttaat attaagctga tgaaatcaag tggaatatat cctgctataa aaatcaacaa
    12181 catagctgag gcaagtggag taaattgtat gttaggatgt atgctggaaa cgagaattgg
    12241 tataacagca gcagcaaatt taatagcatc taaaaagaac ataacagaag ctgaccttga
    12301 tagttttatg ttttgtgaag aattagaagg tatatctgga ggatttgtaa tggatggaga
    12361 tattatgaat cttgtcaata aaccaggttt aggaatagaa gtaaacttat gataaatttg
    12421 gaggttaaat atgaatacac ttttttcaaa tccaggtagt atacttgctg taatgacatc
    12481 aatgattgca ttgggttttt acttacaaag atacaaagcc attaaaagct taggaccagc
    12541 acttacaata atcataatgg gaataatact ttcaaactta aaagtagttc cagtaagtac
    12601 tgagttatat ggaactattt caacatatgc tattccagtt tctatgacta taatgttgat
    12661 gagtgttgac ttaaaagaaa tgacaaaatt atcaagagaa cctttaattg caatttttgt
    12721 agctgtatta actgtaagta tcatggcatt tttatttgga ttagtatttg cagaaaaaat
    12781 atcagaaggt tggaaggttg ctggaatgtt tgtaggtaca tatactggtg gaagtgctaa
    12841 tcttacagct attggaacag gtcttaatgt aagtagacaa actcttgctg cagcaaatgc
    12901 agcagactat gtaattggag taccaacatt gatatttatg tttgctctac cagcaatatt
    12961 aaaaaattca aagaagttta aaaaactttg gccatatcat gtagaagaat cagaattaga
    13021 ggattgtcaa aatgaagaat ttatggagtc aaaagaatgg agtattaaag atatagcttg
    13081 gatgttggct ataggttttg ttgttacaga agttgcaaca atacttgctg gatatttcaa
    13141 ttcgagtttt agtagtgcag caagaatact tttagttaca acaatttcaa ttataattgc
    13201 tcaattaaag ccagtaaaga aactaaaggg aaatttagat ttaggattat ttgttgcatt
    13261 attcttttta tgtacaatag gtttttcagt agatataaaa gaatttttag gttcaacttt
    13321 tactataaca ctttactgtt ttagcataat ttttgcttca tttgttttcc atttaggcat
    13381 aactagactt ttaaagataa agtatcaata tgtaatactt tctatagtag gagcaattgc
    13441 tgatggtcct acttcagctt tagtagctgc ttctgcaaag tggaattcgc ttgtaagtgt
    13501 agcagtcgta atgggagtaa ttggtggagt attaggaaat tatgcaggta tatcagtggc
    13561 atatgcaata aagatgtctc taggattata ggggggagtt taattgataa aatttaaatt
    13621 atacatatct ggactataca gtggaaatgt aatctttgat ggagatttat taattgaaaa
    13681 gttgaatcct tttacaaata aaatagaaag tttaaaacca ataagcaagg aagaaaatac
    13741 atactattta aatcttacaa aaatagattt aaagtcttta tttaataatt ttgatgtata
    13801 tactaaaagc ttagtaaaca cagataaaga cacagttata aataacttag gagaaacgca
    13861 ttctaaactt aatgaatata tatgggttca aagaaacaaa aagttcccac tagatataat
    13921 tattgtagat aataaaatag taggttttat ctgtttatcc agagaaactt gtactatatt
    13981 aattatggat ggatatgaag agtatactgt attaaaagaa tgggaaaaaa ctcataaaaa
    14041 tgaagagata tattctataa gatttggtgg aaattatatg attgatatga aagatggtat
    14101 aaaactttct acagatgtat atctccctga ttttgtagat tctaccaaaa aagcaccgac
    14161 aattcttatg agaactccat atggaaaaga aaatgataaa gaaatatatt ataaatatgt
    14221 acaaagagga tatgctgttg taatacaaga tgttagggga agaaatgaat cagaaggtaa
    14281 gtgggaacct atgattcatg agagggaaga tggagatagt accataaatt ggatagtatc
    14341 acaggaatgg tcaagtggaa tagttggaat gcttggagca tcatatcttg gttatgtcca
    14401 atgggcagct gcatcttcag gcaataagca tcttaaagct ttagttagta tagtaacatc
    14461 aggaagccct tttattgata taccaagaaa aggaggagct tttgtatctg gtatgcttgc
    14521 atgggcattt atggtatcaa gaaataaagt tgatagaagc aaaatggtaa gagatgattg
    14581 ggatgatgtt ttaaacatac gaccaataga aaatatacct gttgaagctc ttggatatag
    14641 aattgaattt ctggaagaat ggttaaagag agtagaaaaa gatgagtatt gggatttgat
    14701 ggattggcat ttacaaaaag ataaaataaa tgtacctgca ttggttgtat ctgggtggta
    14761 tgatgataat agtatgggaa ctacagaggc cttagatgtt ataaaggact atgaaaaagg
    14821 aaagagaaag gctattctag gtccatggat gcataattca aatactttaa gagatataaa
    14881 tggtatttct ttaggaaata gttcattaag atatgatttg gattataatt atctattatg
    14941 gtttgataaa tacttaaaag gtatagaaaa taacatagat acgactgctc cagtagagta
    15001 ttactctgta ggttctaata agtggaagac agaagaaaat tggccaataa taaataagat
    15061 agataaaagt atgtatctaa taagtgatgg aaatgctaac acatctttag gaaatggtag
    15121 attagtattt gataatggtt tagaagaaaa gtatgatagt tatatatata atccaaaaga
    15181 cccatcagta caactaattg atatgtcaga gaatgaagtt ggagttccaa ataactacaa
    15241 agatttagaa aaaagaagtg atatgttgtg ttatacatca gatgctttta gtgaagaatt
    15301 tactgtaaca ggtgatataa agttagagtt ttttgcatca agttctgcca aagatactga
    15361 ctgggttata aaaattatgg acgtggattt agatggaaat tcaattaaat tagctgatgg
    15421 tatacttagt gctagattta gaaatagttt ttataagtca gagtttatgg aagaaggaga
    15481 gatttataag tttacgatta taacttcaaa aatatcaaac acgtttaaag ttggtcataa
    15541 aattagacta gatataacgt ctagtgctaa aaactttatt ttccaaaata gcaacacgac
    15601 agagggatat aatagtattg aatatataga agcaaagaat acgatttatc atggaggtaa
    15661 atatccatct aaattgatat tgccaataga gaataagtaa atttatatag attaaatagt
    15721 gaggaggtgt ctcaaaatga attttttagt tcgtgagaca ctttctttta tacaaaatca
    15781 aatgtatttt catcatttca acaatgaaaa agaggcttat ctctctgttt tgagatagcc
    15841 tcctataagc taaattgatt attttgtagc tgcaacaacg ctcatttcaa ctaacaaatg
    15901 ctctctagca agtctagctt caacacaagc tctagcaggt tcaaatcctt tttcaaccca
    15961 agcatcccaa acagagttca tagcttcaaa gtctttcata tctcttaaat aaatagtaac
    16021 agatagcaaa tgttgcttat ctgaaccata tttgtttaat aaatcttcta ttttagctaa
    16081 aacttcagtt gtttgttcaa ttactcctcc ttcagcatga gtttgtccac ataaataaac
    16141 tgtattgtta tgaactacag ctctactcat tcttccagtt ccttcatatc tctttatttc
    16201 catattttaa atacctccat agttaaaaaa tctattaaaa atctaaataa taaattaaaa
    16261 aaagtctata ctatataaaa ttatattata tattctgata ataatccata aaaacatata
    16321 actttttagc tataattatt attgttatta attgaaaaga tttattagtt acttgacata
    16381 gtttacactt ttaattatag tataaattgg aatatttaga taattattat ttaatgtata
    16441 agctaagttt ttaattaata tggttttata catttatata gaaaagaggt acgtatgagt
    16501 agcacaatca aatcaaatcg aataaaaggt ataatgttta taatagcatc agcgcttggc
    16561 tttgcaatga tgtctgcatt cgtaaagcta gctggagatt taccaagttt tcaaaaagtg
    16621 ttctttagaa atctggtatc agctataata gctttttggc ttatcataaa acataaagga
    16681 agtctaactg gtaaaaaaga aaatttaaaa gtacttttat ataggtcaat atttggaact
    16741 ctaggagtta tatttaacta ctatgcaatt gacaagttga tgctttcaga tgctaatatg
    16801 ctaaataaaa tgagtccctt ccttgtagta atattttgtg caattgctct aaaagaaaaa
    16861 ataaatgtaa agcagatagg agctattata attgcattta taggagcttt attcataata
    16921 aaaccaacat ttagtgtaga aataattcca tatcttgggg gaattgcagg agctgtattt
    16981 gcagcaatgg catatacttg tttaagagtt cttggagata gagaagatta ctatacaatt
    17041 gtatttttct tttcagtttt ttcattagtt actgtagggc caattgcttt tgcagtatat
    17101 gaaccaatga cccttatgca acttatatat ctattactag ggggagtatt tgcaagtcta
    17161 ggtcaatttg gaataactct agcatataaa tatgcacctg ctaaggaaat ctctatattt
    17221 gactatagta atataatctt ttcagcaatt ttaagtatat tcttattcaa tgtctatcca
    17281 gatatgttaa gtgttgttgg atatttaata gtattttcgg cagcatttta tatgttttta
    17341 tacaataaga agttagataa attagacaaa gaaaagaaga agtaaactag ataaaagtgt
    17401 ttttataatt tgtattgaat atttaagtct ttgtattaaa attaaagaaa atttaattaa
    17461 aaatgtttgg tatattaact tataacagca gttaaaattg aaaaattata actgctgttt
    17521 cttttattaa aaatatccaa atgtctgtaa aaatagacta taatagagta gtataaataa
    17581 tataaagggg ataaattaaa gtatggaaaa agtgaaagtt gctgtgattg gagcaggtaa
    17641 tagaggaacg tatgcatatg ctccatatat ttatgaaaat tctgatgtat gtgaaatagt
    17701 tgctgtagca gaacctaaaa aaggaagacg agaactattt acacaaaaat ataacctaga
    17761 tagtaaaaat gtatttgaaa ctttagaaga cttttttaaa catgacaaga tggcagatgc
    17821 agtaataata gctacaaatg atgatagaca ttatgatgta gcaaaactag ctcttgaaaa
    17881 aggttatcat gtactattag aaaagccaat gtctaatagt ttagatggtc tggtacatat
    17941 agatgacttg tgtgataagt ataaagataa gatttttatg atttgccatg tactgagata
    18001 ttctccattt tataataaat taaaagaaat tgtagaaagc aaaaaattag gagagctagt
    18061 tagtatacaa tataatgaaa atataggata ttggcatttt gcacatagct ttactagagg
    18121 gaattggaga aatagcaatg aaaccagccc tttaatttta gcaaagagtt gtcatgacat
    18181 ggatattttg ttatatttag taggaagtag atgcaaaaaa atatctgcat ttggaagctt
    18241 aaagcatctt aataaccaaa atgctagtgg agagatggca caaaattgtc ttcagtgttt
    18301 agttgaaaaa aaatgtccat attcagcaaa gagaatttat ttagaaaaag atagaagtat
    18361 aaatagagct gttcacataa atccaactga agagaatcta ttaaatatac ttaagacaag
    18421 tccatatgga agatgtgttt acagatgtga taataatgtt gtagacaata tggtaaatat
    18481 actacagttt gaaaatggag tgacggctac ttttaattta tgtgcattta ctaaagaaaa
    18541 tggaagaact ataaagttaa tgtttagcca tggtgaagtt ggtggggatt taaataaaaa
    18601 tgagataaga attaaagaat ttggaaaaaa cgaagaaata gttatgaatc catcaaatca
    18661 acagaatatg gtagaggaat atgatagaaa tcttatagct gaatttatta aattagtttc
    18721 aaataaagaa ctagaaaagg gtagagtagc agcaaaagaa gctatacaaa gtcatgtaat
    18781 ggcatttgca gcagaatatt ctagggtcag tgatgaagta gtgtatatag aagaattttt
    18841 tgatagtgct aagcaaatga ctaaggagat agaagaaact atattttaat taataaaaat
    18901 ttattaaata aaataaagat agattaaata atagaaatac gaaaatatgt gttctattaa
    18961 ggaatctatc ttttttatta aggttttttc ttatccctat caaaaaaatc catacattct
    19021 gataaaagat aagaaagtaa agcgaataag atttctgtac ttaaaggaat cgttactgaa
    19081 tccataaagg tatcaattat gttcatagct agaaaagtta gtataaaatc aattataaat
    19141 tcgcaaagtt tatatattga gtatggtaat ttgtttacat atctgaatat atctaaaata
    19201 gtagtgcata gaaaatcaat tggagtggtt atacaaaaat atattaaaaa gaaaattaat
    19261 acagctccaa gagatttata ttcaaatcct aagaatgata agaagccaat tcctataacc
    19321 gtgaaaatac aaaaagttat accaaaaaaa acagcaaaaa ataaaaatac agaaataaat
    19381 tcgcctaaag gaatccttct tttattactt atcttaatca actccttaat ttatgatatg
    19441 aaatttatat aaataataac attcttaaaa attcataata gtcctctgtt tcaaatagta
    19501 ctgtttgaga atctattttt ttcatatttg gataaaaaga ggccttaaaa gctttataat
    19561 gttctctaaa ttttatttct atcttaaatt tatctggcaa ttttattaag tgcctagata
    19621 aatctccaga taaagctttt ttgacacctt tttcaatttt ttttagtgca aggtttggat
    19681 ggattgaaat tgaaccattt ccaattcctt ttgacacagg aacagtgact atatttggat
    19741 ttagtttttt tgcactctca caaagcattt catctccact taaaaatgct acaggaacat
    19801 tataatatgc agcaatataa gcatttatag taaattcaga tgctatttca tcatttattt
    19861 taaaatagtc ataatcaata tccatagtat gggaaagtgg attaccatta caagtagctc
    19921 cagagtgata gccggtgaat atacatgcat caaagctttc atcaattcca gccatcataa
    19981 ctagtgggtc tttggtccat cctctaagta ttttgacgtt ttcaggtaaa atatttggat
    20041 taatatttct accactgtca tgtgcatctt taacaagtat ttcatgtaca ccagattgag
    20101 tagctccatc acatgctgct gttatctctt tactcatttg tgttctatag tgttgcgaaa
    20161 attcacattc aagttttgtt tcatcccaat ttacaatacc acaagtacct tctatatcag
    20221 cacttaaata caatttcata atatataccc ccttatgttt attattgatg ataataacag
    20281 ataacagaaa atacataatc aataaagggc ataaaaatat tatgtcttac tattaattat
    20341 tattaaatct gtaactgaaa aataactaaa ttggtattaa aaaatataac actatgtgtc
    20401 atttatttat atagttttta tatctgatgt ttatataaaa ttgtaacata taagtggtta
    20461 catttactag tttaacatag ttaaaatagt taggtattat ttttaagtta aattgattat
    20521 tataaaatcg cagaataaaa gaaagattta atttattaaa atgcatgaaa tgttttttcc
    20581 tcaacataat gctaaattaa actcaaaaag aaataataga aaaatcttat gtagcttaga
    20641 aagaatgtga atgatttaag ggaaaaatag aaatttatta tataatatta ggctgtatta
    20701 tataatacag cctaatatta tatgtatatg tgacataaaa tcttggtaag tgtaaataaa
    20761 ataaatgtgg aaaacaagtt aatgaaatca agaaaaaagt aatttaaaat tcaatttcat
    20821 cttcccaatt aaattctcct gatttttcta cactcttagg ccagtgacta caccatttag
    20881 gaatggacgg attttcaacc ctatcaacgc ttggagtata tggctttaag tctataacag
    20941 gactattatc attagcatca atatatggta tttttattat accattttca tggtcgatat
    21001 tgataatttg tacagcagtc aatgctattg gattgggtct tataggtgac cttgttgcaa
    21061 atattcctat aacgtctggt ccacttttat aaggttttgg ggtttctaaa atacttctta
    21121 gttcaggatt atcaaaccca tcagcccacc aaaatacatt taaatgactg aaatcgtcga
    21181 gttcatttaa tgcaggtaca tactttttgt ctaatttaat aaagacctct tcgccttgaa
    21241 tacatatttt acctatagga tttattaata tttctttcat aatattacct ccaattattt
    21301 aatttatcat ttgtaatttt agggtataac atgacatcat gtgagggtca atataaaata
    21361 ataaataaaa atattaatag ttagaatgat aatacatttt ttacatggag catgacacca
    21421 gtaataaggc aatcttcgtc aatatcaaaa gtagaggtat gcaaagggga agtaatgttt
    21481 ttttcacgat ttgcacaacc aaggtggtaa aaagctcctt cacagtgtct tagaaaatac
    21541 gaaaagtctt cagccccaag agtgggcgag tctttaagga taatattttc ttctccaaac
    21601 aattctacag cattttgttt gacgtaatct actagatggt ttgaattgat aagagctgga
    21661 taaccttcct caatttcaac agaaatactt cctccaaatg ttttacaagt aaaatcgcaa
    21721 atttctctaa ttcgtttttt tgaaaactct ctagtttcag gagtcaaggt tctcaaagta
    21781 ccccttataa ccactttatc acaaactata ttttccttga ttccaccttc aatctttcct
    21841 agagaaataa ccacagaatc agttggattt gtgtttcgac taacgattgt ctgtagagct
    21901 gtaataatat gagcagatat aacaatagca tcaatacctt gatgtggata agctccatga
    21961 cattttgaac catgtacagt taattgaagt gtatcagtgg aagcatttag agtgttgtat
    22021 tttaattcaa ttagattttt gttgatattg gaatttacat gaagtccaaa tatatatttt
    22081 acatttgggt tttcaagaca tccatcttct atcataagtt gagccccacc aatagtttcc
    22141 tcggcaggtt gaaaaaagaa ttttacattt acatttaagt aatcctttaa tttaaatagt
    22201 atattacaag tacccagtaa aatagcagtg tgtgcatcat gaccacatgc atgcattttg
    22261 ccaatattaa tagatttata agaataatta agttcttctg ttataggtaa ggcatctata
    22321 tcagctctta tagcaactgt ttcaaagttt ggactcacgt taatgtatgc agttatccct
    22381 gtatgattct tatattcaat ataatttata cctatttcat ttaagtattt aataattttt
    22441 ttcttagttt gaaattcttc taatccaagt tctggagtct tatgtaaatc tcttcttata
    22501 tttataaccc aatcatttat ctcatgacaa agagttttta tattaagcat aaaacacatc
    22561 ctaactatat taaaaattta tttttcttca ttaattatat tattttatgt aaatcattat
    22621 tatgtatcaa gtacaaataa aatatcttat aattatatta gagatattta gtatggagaa
    22681 gaatatatca ttttataaga agaggtgttt aaatgttagg aataattgcg ccatctgggc
    22741 cattaagaaa tacaagtttg gaggaaataa agtttaattt agaaagttat ggttatgaag
    22801 ttaagttttc tgaaagttgt agtttaaatt ataaaggtta tttagctggt aatgatgata
    22861 ttagagcaag ggatatagaa gatatgtttt tagataaaga tgtagatata attatgtgct
    22921 taagaggagg ttatggaaca acaagaatat tggataaaat aaattatgat ataataaagc
    22981 aaaatccaaa accatttata ggtttttctg atataacagg tttaaattta gctttctata
    23041 aaaattgtgg tcttttacca tatcatggaa taatggcagc aaatgtaggt aaatgggata
    23101 aatttaccta taaatcattg gtaaatgctt tagaatttaa agatgaatta tatttagaaa
    23161 atccaaaaga agaaaagatt tatactgtat gtgaaggtaa agcagaggga ataataatgg
    23221 gaggaaattt atccttaata attgccacaa tgggaacaaa atatgaaata gatgcaaaag
    23281 ataaaatttt gtttattgag gaaattggag aacctcaata taaactggat agaatgttaa
    23341 cacaactata ttcttcagga aaacttgagg aatgtaatgg tataattttt ggagatttta
    23401 aggattgtat tgaagaaaat gatttgatgg aattactaat agaatttgca aataaggtca
    23461 ataaaccttc tatatataat cttcagtcag gacattgtat cccaatgata actattcctt
    23521 tgggcagaat gtgcgaatta gatgctacag aaaaaatcgt taaattaaaa aaatagtgtg
    23581 tatataaata taatagaaat atggtataat cttatacaag taaaaattta gctaggagga
    23641 tgaaaaatgt ctgatgatag aataatagac tttaacgaac taaagaacaa agttaaagat
    23701 tctgatgtag ataaatttga gcaatacata tataacttat atttttctgt tatggatgga
    23761 aagatgtcta tggctgagtt ttcaagaaaa atattcgatt atatgagaga taacaacata
    23821 tctcaagaaa aatttatgaa aatacaaaag caatttatgg agagatatgg tatggacact
    23881 gaagaagtag aaaaacaact tagaaacttt ggaatcgacc cttctacggc aggttttatg
    23941 agtaataata cttccagcaa agtatctaca gaagatttag agtcatttaa gaagagtgca
    24001 ggattttatg agaaatatgg agaaaaaatc caaccaaaga gttgtataac aacatttata
    24061 aaaaatgact taaatgatat taatgtaata atcgaccaag aaaagataat gctttgtagt
    24121 gatagaaaaa taaatcttat ggattcagaa ctaaatgagt ttttattaga atataagaat
    24181 atgtttaata aaaaaataaa ggtagtaatg tgcgaaacta cgaataagta tgattattaa
    24241 aaaatgaatt taaatactga agtagtatca attaattgta ctacttaaaa ataaaaatcg
    24301 caatttatta ttccttataa atttgtataa ggaatatcta aactgcgatt ttttatattg
    24361 tgaagattag taataataga tagtgtttta aattgtaatc ttctcactaa aactgtgttt
    24421 ttctattaga aattttatta aaaataaata tctgataatt gtattatatg ggatgtaaag
    24481 tattagaagc ttaacgaatc tcttttaata cattaactcc attttgaatc atactgttga
    24541 aaaatactaa gtttaaaatc tcagcagggt gaacgttagg aatatcataa gtatctacta
    24601 aattcatagg tacaactata tttttttcaa tattatgttg attaaaatat gattttagag
    24661 ttattgcaaa ttgatatata catatatctg tgcaatcgcc aactataatt atattatcta
    24721 tattatcaaa atccaaattt tctaatgcaa aaaaaccatt agtagaattt ttaggaagaa
    24781 tttgtaggtt ttctatcgac ttaagttcat caaccaattc actttctaca tcattttcca
    24841 aacagtgaac aggataactc aaaagttcta ttgatttagg agtatgagaa tcagtaaatg
    24901 ctattactct atttaatttg tttgatattt tttttgtaaa catttcaatt ggctttatta
    24961 aagactctac tctaggagag tataatgcac cttgtcttgc aaagccatta ttaacatcaa
    25021 ttataaataa agcagtttta ctcaaatcat aattttctat tttttctatt ggtagattat
    25081 ctaaattact ctttaaagct tcaagttcat ttaataagtt atccatagtt atacctccaa
    25141 gataaattta ataaaattgt acatattaat tatataaaag tcaaggagta caaactattg
    25201 tataattagc tgtattgttt tgagtgtaaa agatttgaag caatatctgg atagttagta
    25261 aaaataccat ctacattgag ttttagacag tgtagtatat catcctcttc atttacagta
    25321 tatacattga caccaagtag atttttgtga caaagttcaa ttagagattc atttactaaa
    25381 actagaggtg gatgaagata actattaccc agaaatttag caaaattgac tacattgttt
    25441 ataggtaaat aacacaataa tcctgttttt acactagggt ctaatttatg aaagtttttt
    25501 aagctattgc tgttgaaact agatataaga actctatttt tcatattata ctttaaaata
    25561 agctctaaaa cgcctttttc tatattggga tagtttattt tgtcagtttt tagttcgata
    25621 tttaaagtaa ggtctgtagg tgagattaga attaatactt cttctaaagt tggaatttta
    25681 cattctttat tgctttgata tccttcaaaa gatgagttta gagtttttaa ttttcttaaa
    25741 gtaaagtctt ttacaaaacc atgtccatta aaagttctat caaccttttc atcatgaata
    25801 actacaattt ttccatcctt agttctgtgg acatcaagtt ctattccata tatatccata
    25861 tccaaacatt ttttaaaagc tagaatagta ttttctggat actttccact aaacccccta
    25921 tgagcataaa tattcattta tatggttccc tcctataagt ataacttatc ttataaaaat
    25981 tta
//
LOCUS       DAEHWM010000050        25885 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.051, whole genome shotgun sequence.
ACCESSION   DAEHWM010000050 DAEHWM010000000
VERSION     DAEHWM010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25885)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25885)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25885
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.051"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            392..1213
                     /gene="yidA"
                     /locus_tag="KNP36_002155"
     CDS             392..1213
                     /gene="yidA"
                     /locus_tag="KNP36_002155"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HBF0874025.1"
                     /translation="MYKLIALDIDGTILNTQKRITPEVFESIQEAKRAGAKVVITTGR
                     PLPGVKELLNQLNLTDEGDYVICFNGAIIQEVKSEKIIHDVEMSLDDFDFIYNNVCKK
                     YKTKIHINTMTNLITPNETPGKYTLHEAKLNNIEVKYIQKDKIDESIKICKIMIVDEP
                     ERLEEIIQQLPKNLFNKYTIVRSAPFYLEFLGKTTNKGTALKTLCTNLNIPIENAIAV
                     GDEENDQHMIKYAGLGVAMGNARNSIKEIADYVTDTNNENGVAKVINKYILNKAI"
     gene            complement(1349..1498)
                     /locus_tag="KNP36_002156"
     CDS             complement(1349..1498)
                     /locus_tag="KNP36_002156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874026.1"
                     /translation="MNFFWTKSDFDAWTNEAGLSDDEDIYCLDINEAIVESYKIFKLK
                     QKVLS"
     gene            complement(1505..1990)
                     /locus_tag="KNP36_002157"
     CDS             complement(1505..1990)
                     /locus_tag="KNP36_002157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874027.1"
                     /translation="MSQIEKYNSLDNTQQKIRISIMDMIIDKGSSVTLQEVTEYVSKK
                     LNIEKEYIERTLQYFIYKNIMVVDGNSINFIYPVSALPTNHKVTLRDNRSFSAMCAID
                     AIGTSCTFNQDIKINSICSATGKEIEVIIKNEKIEYVNNPNLRVLHINLDKHLNWAAS
                     C"
     gene            complement(2003..2755)
                     /locus_tag="KNP36_002158"
     CDS             complement(2003..2755)
                     /locus_tag="KNP36_002158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874028.1"
                     /translation="MKLSVRDINKTFVNNRVHTKVLEDISMDIDDGQFVCLLGPSGCG
                     KTTLLTIIGGFQKSERGDVFINDKRVKKPGIDRAFIFQNYALFPWKTIRGNVLFPMKQ
                     QKIPKEKREEMLEELLVMSDLKGKEKLFPHQLSGGMKQRVAMIRALACNPEVLLMDEP
                     LGAVDFQMRQNLQEELERIWIKKKITALMVTHDVDEAVYMSDRVIVMSRDKGRIIDDI
                     NIDIPRPRIRGSQKYEEYKNKLTDTLSKCYEV"
     gene            complement(2932..3561)
                     /locus_tag="KNP36_002159"
     CDS             complement(2932..3561)
                     /locus_tag="KNP36_002159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874029.1"
                     /translation="MEIKISKDKSDRLTKKKTDGSMDILYKIILLVIIFLVWHFAAKD
                     IGSSLLLPMPVDVIKGFFFCVTDAETVTNLFITLQRVLKGFMYALLFGLPIGFIMGFS
                     KTFERVLSPVVDSVRQVPIMAWVPLTIVWFGIGDGPTIFLIAFSGVFPIILNTIQGVR
                     AISKDYYNAARSMGASPIVIFTNVIVPASLPDILTGSRIAISTGWMSVI"
     gene            complement(3522..4085)
                     /locus_tag="KNP36_002160"
     CDS             complement(3522..4085)
                     /locus_tag="KNP36_002160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874030.1"
                     /translation="MQWALSSEEIDIAIICKDAAKQYVNVNSGFEIVGTVVQNSDIFL
                     LSDNNPEKIGVIQNRDYQSELVKKYYKNVEVAPLLGTALAYGLESNLVDGVVIDCIKS
                     IGLEGKRKSTTKLGDYDTYVLVVNKEFKKSKAYSDFITLYNKSVDALKNKATFKKVLK
                     EYRNIRNIDMEEISNWKLKFLKIKAID"
     gene            complement(4095..4319)
                     /locus_tag="KNP36_002161"
     CDS             complement(4095..4319)
                     /locus_tag="KNP36_002161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874031.1"
                     /translation="MENMKNIIILFIIILGSIFIIFFNFEDKEEIKGKLRIGVSDDTS
                     GFVINYMVNRDYFENIKVSDIMDIFTINDC"
     gene            complement(4324..5415)
                     /locus_tag="KNP36_002162"
     CDS             complement(4324..5415)
                     /locus_tag="KNP36_002162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0874032.1"
                     /translation="MKLSKKIQALILFGVMGTSILTGCSSKPKEKEEAKTGKDDYTIT
                     VGYYNCDHMTAGPVAESAGIYKDLGLNVKTVGNGKVPEAMAAGKMDAGYIGTKGLVGA
                     IPKGSPITIAANNHTGGSEYLIVSKDIKEPKDLIGKKIATDMSDFLWTSDYGPETGLP
                     TDPSKYEVVNMDSDKDKYLALKTGKIQAFTSCDPWGSVAENDGAGKIIASTQYKEKAN
                     GKEYNCCSFSLNKNFIKEHPDLAKKLVLAHTKAIEYIYTNPAEAAKIFAKYYNVEEEV
                     ALRTIYKKTVGEGRTLTWKVTGEEYKNNLQMYKDLKALDDIPKYEDTIDTSLLDSCGA
                     DDFDKFIKEKVNPEFPEGMSYEDWKAKVL"
     gene            complement(5450..5908)
                     /locus_tag="KNP36_002163"
     CDS             complement(5450..5908)
                     /locus_tag="KNP36_002163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874033.1"
                     /translation="MLKKIVIISCIVVVLIILSKIVDDNIKEDASIPNVNKETLEYFR
                     KNYKEDIITCAEEDLNNDGKKDLVVIYKKSNNSNEMVVVVSDKNSHYITKPIPAPIEN
                     QTITFKNIDDKAPIEVIVSGSKNGNVGYAIYRVEGKKFVDLFGEDMDKCC"
     gene            complement(5901..6986)
                     /locus_tag="KNP36_002164"
     CDS             complement(5901..6986)
                     /locus_tag="KNP36_002164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416824.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HBF0874034.1"
                     /translation="MNILEIVLNGVKDTIVASIVTLNGASGWLMISFILAGVLHNVLT
                     PRRFQKQLGNKKFSSLIKSTISGMFLPICSCGVIPLGISMYYSGAYLGPVLAFMTSTP
                     IINPIAVVLCLGLLGPKVTIIYLIAGFLVPFLVGFLGNCFGKEELSLHNDSEEEVIEL
                     EEEKRSFMGNMIDGLKWSFGELALTISKYVVMGMVFAGFITTIFPNSIIQKYLGNPGL
                     LSLGSIAILACVMYVCAVGHIPFIAALVASGASPGIAITFLIAGAATNLPELISMFKL
                     IGKRTVIIYSVTLTLSSIIIGYITNLLLVNNNSVNLDATNSSIQLANKLMLNIPDSFE
                     YVCTILIILFAFKSIIPKMKEVIGNHA"
     gene            complement(7013..7198)
                     /locus_tag="KNP36_002165"
     CDS             complement(7013..7198)
                     /locus_tag="KNP36_002165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874035.1"
                     /translation="MSEKYADKLEIKLYQAGKDFSYIKKYGIITKGTLIINQKKKYDR
                     LNKDTIERAIVEAINNN"
     gene            complement(7360..7692)
                     /locus_tag="KNP36_002166"
     CDS             complement(7360..7692)
                     /locus_tag="KNP36_002166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DsrE family protein"
                     /protein_id="HBF0874036.1"
                     /translation="MKVAYIFSSTNTHKILDKMIIPQLEQGTHGVDVLGMFFFMDNTL
                     FLSKGNPVGERLSKLHEKTDMIIMACDQCAIERGIENNLVDGATIGCFPNLYACLGSA
                     GVDQVITL"
     gene            complement(7948..8784)
                     /gene="nadC"
                     /locus_tag="KNP36_002167"
     CDS             complement(7948..8784)
                     /gene="nadC"
                     /locus_tag="KNP36_002167"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HBF0874037.1"
                     /translation="MNYLIIDRMIQDALIEDVPSEDITTNSIVDENSKSTVDLICKQD
                     GIIAGLGVFKRVFEILGDVDVKLYKNDGDRVKNREKIAVLTGSTRNLLVGERVALNYL
                     QRMSGIATITSRYVEKLEGTNTKLLDSRKTIPNLRILDKYSVKVGGGCNHRFNLSDGI
                     LLKDNHIGAAGSVKKAVELARKNTSFVRKIEVEVETLDMVKEAIEANADIIMLDNMSL
                     EMAKQAVDIINGRAIVEFSGNVNLDTIEDIGKIGVDVVSVGALTHSVKALDISMKNLR
                     NI"
     gene            complement(8765..10066)
                     /locus_tag="KNP36_002168"
     CDS             complement(8765..10066)
                     /locus_tag="KNP36_002168"
                     /EC_number="1.4.3.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-aspartate oxidase"
                     /protein_id="HBF0874038.1"
                     /translation="MNLEQDVLIVGSGVSGLYCALNLDKSLNVLVVSKSTIENNNTYL
                     AQGGISTARNIDDIESFVEDTMKAGQYKNRVEAVQVLADESIENVGQIVEYGMPLDKE
                     NGEIDYTREGAHSVNRIVHSKDNTGEVVFKTLLKEAKTRENITLIEDAYLLDILKDGN
                     KCIGARIFKSKKEIHVFSKIVVLATGGIGGLFKNSTNQRHLTGDGIAIALRNNIKIEN
                     LEYIQIHPTAFYEENNEGRRMLISESLRGEGAKLLNKNKERFVDELLPRDVVSKAIFE
                     QMEKDKLPYVYLDATHLDSEYLINRFSFIYNECLARGTDITKECIKVSPAQHYFMGGI
                     HVDLDSKTSMENLYAVGEISCTGVHGANRLASNSLLEGLVFSKRAAKNINSVIDNVKV
                     KFIDVPDMDIDIEQVKKENKILVIKEIERTSEDFGDELFDY"
     gene            complement(10079..10993)
                     /gene="nadA"
                     /locus_tag="KNP36_002169"
     CDS             complement(10079..10993)
                     /gene="nadA"
                     /locus_tag="KNP36_002169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolinate synthase NadA"
                     /protein_id="HBF0874039.1"
                     /translation="MDKDLTYQIKELKKEKNAIILAHFYQPPEIQELADAVGDSYYLS
                     EIARDCKEEVVVFCGVRFMGESAKILSPEKTVLMPVSNAGCAMADMVDEEGVIKLKQQ
                     YPNALVVCYINSTAKVKAHCDVSVTSSSAIKILENIDNKEIIFLPDKNLGGYIAEQFP
                     DKNFIFWDGYCKYHNNIRAEEIIELKDKYKNAEVLVHPECKKEIRDLGDYVGSTSGII
                     KYATNSKNKDFIIATEEGILHELKKNNPNKNFYIPGGKILCTDMKKTTLENLYSTLKN
                     MENEVIVEDEIMEKALNSLLNMHKLAEG"
     gene            11411..12868
                     /locus_tag="KNP36_002170"
     CDS             11411..12868
                     /locus_tag="KNP36_002170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon starvation protein A"
                     /protein_id="HBF0874040.1"
                     /translation="MTTFLIGLAILLIGGALYGAYCEKVFGPDDRKTPALAQSDGVDY
                     VPMKKWKNSLIELLNIAGTGPILGPIQGILFGPIAFILIPIGCVFGGALHDYMSGMIS
                     IREKGAQMPSLISRFLGNKVFQVYNIFLCLLMLLVGAVFIYTPGDLVVTQILNMKSTI
                     NNPVVWIVYGLIFLYYLCATLFPIDKIIGKVYPIFGAILLLSAAGVGIGIFTQGYDLA
                     NLSLANWKGIHPDGIPLIPTFFVTVACGIVSGFHSTQATLIARSVSNEKEGKTTFYNM
                     MILEGLIAMIWAAAAMGIYNKGIPKELVGSPDVIGLVARDLLGSIGGIIAIIGVIVLP
                     ITSGDTALRSLRLMLADYFHYDQKEKKHRVILSICIFIPVIAILIFAKLSASGFNILW
                     RYFSWSNQTIAIFAFAMITVYLIIKEKNYIISLIPGMFYSFVIFSYIFNAQIGFNLNI
                     NISYVLAAIFTVLYAILTVRSGRKLKSKADTKLAD"
     gene            13091..13519
                     /locus_tag="KNP36_002171"
     CDS             13091..13519
                     /locus_tag="KNP36_002171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874041.1"
                     /translation="MNNKLHELEKNLPETSCSFCTHLSFKGPSLDYRYDIRCVISDTK
                     PDFRGCCEYFEPEYTELNTGDLDNLYINFLETCLKVNYNDYINSMYWKLFKERTLLEN
                     NFKCSICGSTENVDVYHVNKNLGRETSKDVVVKCDKCNCK"
     gene            13579..13887
                     /locus_tag="KNP36_002172"
     CDS             13579..13887
                     /locus_tag="KNP36_002172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1540 domain-containing protein"
                     /protein_id="HBF0874042.1"
                     /translation="MKNNNLNCAATNCAYNTSGYCYAGSIKVDGMQATTTENTYCASF
                     EDKYTSGITSRSNETNQVDTDNIHCEAVKCKYNKNELCKAEKVHINERNASCETFEMK
                     "
     gene            complement(14034..15056)
                     /locus_tag="KNP36_002173"
     CDS             complement(14034..15056)
                     /locus_tag="KNP36_002173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBF0874043.1"
                     /translation="MEDNKGLARDSSKYKIVSISVVVIILITFWYMLNMVLLTFIMTF
                     IFYNLLVATRKRIKKFSSLNIPDSLIIIVLYALFAILLVLISYAVVPIIIVQLTELSR
                     VFSDFDVNQFAQSLGPKLYPIVSKLDFNKYISQAGLLIASTATKVGSFGVNILLAFLL
                     SLLLLLEKNEIKNFGDKLSDSKISFIYNSLVFFGKSFVKNFGEVMKVQVMIAFINSVV
                     SMIFLGFMGFPQIWALGFMIFVLGLIPVAGVIVSLIPLTVIAFNTGGITKVFGVLLMI
                     CIVHAVETYILNPKLMSNRTKLPVCFVFIILLVGEHYLGVWGLLIGVPIFMFLMDILG
                     VKFTSR"
     gene            complement(15231..15737)
                     /locus_tag="KNP36_002174"
     CDS             complement(15231..15737)
                     /locus_tag="KNP36_002174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX domain-containing protein"
                     /protein_id="HBF0874044.1"
                     /translation="MELWDLYNADGIKTGNVIKRGNSIEEGYYHLAVEVWILNSNSQI
                     LIQKRSKSKKTLPNMWGMTTGCIVSGEDSLEGAIREAKEEIGIDITKDEMKVFRSMIH
                     EDTLWDVYLVKKEYDISKAILQEEEVSDIKWVSTDEIRQLLKEGLFFEYPEIYELLYE
                     IDNNKLNI"
     gene            complement(15797..16498)
                     /locus_tag="KNP36_002175"
     CDS             complement(15797..16498)
                     /locus_tag="KNP36_002175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874045.1"
                     /translation="MGKISLKSMIRLFSGFFIFAISSVLMINAHVGLMPWDVLHQGLS
                     IKLGITIGQASIMVGVVIVILDAVFGENIGWGTLLNMTFIGIFIDLVIFSGVIPHASN
                     TYIGVFMVVIGIILAAIASFLYLGVCLGSGPRDGLMIALQKKTNKSVRLVRTILEILA
                     LVVGWLLGGSVGIGTLVSALGLGYVLQIVFRIFKFDTKLLKHRFIIDDIREWKEKKSN
                     EHKCKSSIVIKNEQN"
     gene            complement(16716..17786)
                     /gene="buk"
                     /locus_tag="KNP36_002176"
     CDS             complement(16716..17786)
                     /gene="buk"
                     /locus_tag="KNP36_002176"
                     /EC_number="2.7.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="butyrate kinase"
                     /protein_id="HBF0874046.1"
                     /translation="MTYRILAINPGSTSTKIAVYDGEEQILVKTIDHPAEEIAKYNTI
                     QDQFEMRKEAVLNILKENSIDLKSLSAIVGRGGVLPPVKSGAYLVNEEMIDVLRHRPV
                     LEHASNLGAVVAHAISEPLGINSYIYDSVAVDELIDVARISGLCGMDRSSAGHALNTR
                     AMALKYAKDKGKDYKSLNLIVAHIGGGVSIYLHEKGRMVDMLSDDEGPFSPERSGRVP
                     ATKLVAACYSGQYSEREMTKKIRGKGGIVSYLNTVDAREVEKMIAEGNEEAKIIYEAM
                     AYQLAKGIGELATVVDGKVDAIIITGGIAYSEMFTSMVKKKVEFIAPVEIMAGENELE
                     SLAFGTLRVLNGEEEARIYSEN"
     gene            complement(17839..18414)
                     /locus_tag="KNP36_002177"
     CDS             complement(17839..18414)
                     /locus_tag="KNP36_002177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate oxidoreductase subunit beta"
                     /protein_id="HBF0874047.1"
                     /translation="MTKSILLVGVGGQGTILASKLLTMGLMEAGYDVKMSEIHGMSQR
                     GGSVSSQVRYGDCVHSPVIEIGGADILVSFEKMEALRWFNYLKPEGKALVNNHRIDSM
                     TVLIGGAEYQESDIDAELSRLNAKVINAADKAEELGNSKIMNVILLGCLVKSMQLESI
                     DWEKIISENVKPKFVELNIKAFHEGMEMVSK"
     gene            complement(18416..20203)
                     /gene="iorA"
                     /locus_tag="KNP36_002178"
     CDS             complement(18416..20203)
                     /gene="iorA"
                     /locus_tag="KNP36_002178"
                     /EC_number="1.2.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate ferredoxin oxidoreductase subunit
                     alpha"
                     /protein_id="HBF0874048.1"
                     /translation="MKQLMTGNEAIARGAYEAGVKYASAYPGTPSTEILENIATYKDA
                     IVAEWAPNEKVALEAAIGGSIAGARTMASMKHVGLNVAADPIFTYAYTGVNGGMVLIT
                     ADEPGMHSSQNEQDNRMYAKFAKIPLFEPSTSQEAKDMIKEAFEVSEKYDTPVLYRVT
                     TRLCHSKGLVECYDREEVEIKEYVKNAKKMVTVPANAQIRRGVVEERMEILKKFSNET
                     DLNYYEINDTKIGVIASGMCCNFAKEVFGKNASYMKLGFTNPLPYEKIKEFAEKVDKI
                     YVIEENDPFIEEQIKAYGIDCIGKDVIPPYGEMTPDVLRKAIFGKTNDTIEYKSELVT
                     PRPPSFCAGCPHRGFFYELGKRKNLIVGGDIGCYTLGFAPPYNGIDYVVCMGSAFGTA
                     HGAQKVLNMKDDNEKRLVGVLGDSTFFHTGINGLLDVVYNRGNSISVILDNRITGMTG
                     HQENPGSGYTLQGAKTKEVDIEGLVKACGIEHVRVINPNNLKEVNEALDWALAIEDEP
                     SVIITRWPCVLKKFSKEDIEEFNNPFKTKCKVDHDKCIGCKLCLKTGCPALSFDKENK
                     LSNIDRNQCVGCGVCAQVCPKQAIVKEEK"
     gene            complement(20264..21523)
                     /locus_tag="KNP36_002179"
     CDS             complement(20264..21523)
                     /locus_tag="KNP36_002179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBF0874049.1"
                     /translation="MSQSMVGKHAMWPKENDVIFSISGRAQAAEKAFGMDNVINATIG
                     ALMDDSGKLITMKTVYEEYKALDNCEIGAYAALEGQPDYLEAVKKVFFRDYLPEGHIR
                     VLASPGGSGAIKLAVWNYTNEGDEVLTSDWFWSPYVSIAEEANRKVVNYQLFDENRRF
                     NFESFKEKFVNIAEKQGRVFTIINTPAHNPTGYSVADDEWDKILDLSKEVAKDKDKKI
                     IFFVDSAYIDFAGDDDVCRKFFKKFSNLPENVLVLVGFSMSKGFTAYGMRMGAIICIS
                     SSEDVAEEFHYSCVHSCRANWSNCNRSAMAVLSNIVNDPKKFKEYEDEKEIYKNMLTR
                     RADVFVKEAERVGLEILPYIAGFFVSIPCDNPKEVCEELTKHNLFAVPLKMGLRFAVC
                     AVSEDKCKKAPSIIKEALESLEVKINN"
     gene            complement(21785..23785)
                     /locus_tag="KNP36_002180"
     CDS             complement(21785..23785)
                     /locus_tag="KNP36_002180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0874050.1"
                     /translation="MILLRKKIGIIASDIELKERIEELYREDVENGTIIIDILNLDLM
                     ENQGRILVEKGAQAIIGRGGGYSLVIDTVNVPVIPMNMKSTDLLRAIEIAKKYSKKVV
                     LILGDNEVSFDYVGWRNVISTEITEEWFESKYEIRSKVVKYIDQKDEVVIVGGGLACS
                     FARQYGIDSVFATASDESIREAVEYCKKLLDTLGEEKFNNEVLRNILDGIKDGVIAID
                     SNGSIILYNESAKNMLKVERKCALNKYILDVFPKMEWMLDCLHEKEDVEDRKIRNINN
                     LIVNTRTTLIKVDNSTYGVLGIIQDITKLQNLERKIRFDLNQKGLYARYTFDDFLFKD
                     KLTKEFIEEAKKIGKSDYTTLLYGESGSGKEIIAHSIHNISKRKDRPFVAINCATIAE
                     NLLESELFGYEEGAFTGARKGGKRGLFELAHGGTLFLDEINSLSFNIQTKLLRVIEER
                     QIMRIGSDYIIPLDIRIIAATNESLTEKIVMGTFRADLFYRLSSLEINIPPLRDRRED
                     IIPLFNNFVNEVLKDDGLNGINSIDENFVLTKDEMDKLYNYSWPGNVRELKTIAQKYV
                     VTGKIKLRQDRDFKTKKLLPNSEVDKFNSETTASVEVQDESINISKINDGKISIDIKE
                     VNKYVEEKIISMLFAQGLSKNEVAQVLGISRTSLWKKYNKNI"
     gene            complement(23793..25680)
                     /locus_tag="KNP36_002181"
                     /pseudo
     CDS             complement(23793..25680)
                     /locus_tag="KNP36_002181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897561.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
     gene            complement(25707..>25885)
                     /locus_tag="KNP36_002182"
     CDS             complement(25707..>25885)
                     /locus_tag="KNP36_002182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0874051.1"
                     /translation="RIVKKFLNNNLTVSIGIDTCKNSSIDIKEIIENADKALYKAKES
                     GRNRCLHYHDFKNF"
BASE COUNT         8425 a         4631 c         2746 g        10083 t
ORIGIN      
        1 ctttatatta taatcatgtt gaataataac atatgattaa tggaattaca atattttata
       61 acacaaaact aactaatata acaaattacc atcagtctat ttattcaaac ttctaactat
      121 ataatataca tttatttata ttaacaatgc aaacgatacc attatttgta attaagaatt
      181 ttggaattat tgattacaaa gtttttacat tctcatctca cataagtaat atttttatca
      241 aaaaattaat attattaaac tttctaaatt acttatctct tgatataata gtatacaaaa
      301 caaaccatat ttcccactga aactttgttc aacactagct gtgtcaacgt tttcacagga
      361 aatttgagta tataatttat tggaggttga tatgtacaaa ttaatcgcac tagacattga
      421 tggaacaata ttaaatacac aaaaaaggat tactcctgaa gtctttgagt ccattcagga
      481 ggcaaaaagg gctggggcaa aagtagttat aacaacaggc agacctcttc ctggtgtaaa
      541 agaacttcta aatcaactaa atttaacaga tgaaggtgat tatgttatat gctttaatgg
      601 agcaattatt caagaagtta aaagtgagaa aatcatacat gatgtagaaa tgagtttaga
      661 tgattttgat tttatatata ataacgtttg taaaaaatat aagactaaaa tacacataaa
      721 tacaatgaca aatttaatta caccaaatga aacgcctggc aaatatacac ttcatgaagc
      781 gaaattaaat aatatagaag tcaaatatat acaaaaagat aaaattgatg aatctattaa
      841 aatctgtaaa attatgatag ttgatgaacc agaaagattg gaagaaatca tacagcaact
      901 acctaaaaat ttattcaata aatatactat agtaaggtct gctccttttt atctagaatt
      961 tttaggtaaa actactaata aaggaactgc tcttaaaaca ttatgtacga atctaaatat
     1021 acctatagaa aatgctattg ctgttggcga tgaagaaaat gaccaacata tgataaagta
     1081 tgcaggtctt ggtgtggcta tggggaatgc acgtaatagt ataaaggaaa ttgcagatta
     1141 tgttactgat actaataatg aaaatggagt tgcaaaggtt ataaataaat atatacttaa
     1201 taaggctatc taatcatcta aaaaaactaa aaatatacct ttagatttaa atacttttca
     1261 catccctact ctatactaat ttatatagta tggatattac ctatcatttt tatctaaagg
     1321 tcatttttag tttttcatat atgtatatct atgatagtac cttttgtttg agtttaaata
     1381 ttttatatga ttctactatt gcctcattaa tatctaaaca atatatatct tcatcatcag
     1441 ataatcccgc ttcgtttgtc caagcatcaa aatcactctt cgtccagaag aaattcatta
     1501 tatttcagca actagcagcc caatttagat gcttatcaag atttatatga agcactctta
     1561 agtttggatt attcacatac tcaatctttt cattttttat aattacttct atttccttac
     1621 ctgtagcact acaaatagag tttattttta tatcttggtt gaatgtgcaa gaggttccta
     1681 tagcatctat agcacacatt gcactgaaac ttctattatc tctcaaagtt actttatgat
     1741 ttgttggcaa tgctgataca ggatatataa aatttatact attcccatca acaaccatta
     1801 tatttttata aataaaatat tgtagtgtcc tttctatata ttctttttct atattcaact
     1861 ttttacttac atattcagtc acttcttgaa gtgtaacact agaaccttta tctattatca
     1921 tatccataat agagattctt attttctgtt gtgtattatc caaactattg tatttttcta
     1981 tttgactcat gtctactcct ctttaaactt cataacactt tgataaagta tcagttaatt
     2041 tgtttttgta ctcttcatat ttttggcttc ctctaattct aggtcttgga atatctatat
     2101 ttatatcatc aataattctt cctttatctc tcgacattac tataactcta tcactcatat
     2161 atacagcttc atcaacatca tgagttacca ttaatgcagt tattttcttc tttatccata
     2221 ttcgttctag ctcttcctgt aaattttgtc tcatttgaaa atctacagct cctaatggtt
     2281 catccattag taatacctct ggattacatg ctaaagctct tatcatggcc actctttgtt
     2341 tcattcctcc agataattga tgcggaaaca gtttttcttt tcctttcaag tctgacataa
     2401 ccaaaagttc ttctagcatt tcttctcttt tttcttttgg tattttctgc tgtttcatag
     2461 gaaatagaac attacctctt atagttttcc aaggaaataa agcataattt tgaaatataa
     2521 aagctctatc tatgcccggt tttttaactc ttttatcatt tataaaaaca tctccacgtt
     2581 ctgatttttg aaacccacct attatagtaa gtaaagttgt ttttccacaa cctgatggtc
     2641 ctaaaagaca gacaaattgt ccatcatcta tatccatact tatatcttct aaaacctttg
     2701 tatgtactct attatttaca aatgtcttat ttatatctct tacacttaac ttcattaatc
     2761 tgcaaacctc catctacaaa ggattttatt tataaacttt aataccctat ctattataaa
     2821 tcctattaaa gctgcaaata tcataagccc aattaataca tctgtatgca ttaatgtttg
     2881 agcttgtacc attgagtaac cgagaccggc actcgtagct ataaactcgg ctcagataac
     2941 agacatccat cctgtactta tagcaatcct tgaaccagtt agtatatctg gaagagatgc
     3001 gggaacaatt acatttgtaa atatcacaat tggcgatgct cccatacttc tagctgcatt
     3061 ataataatcc tttgatattg ctcttactcc ttgaatagta tttaaaatta tagggaaaac
     3121 ccctgaaaaa gctattaaaa atattgttgg accatctcct ataccaaacc atactatagt
     3181 aagaggaacc catgccatta ttggaacttg ccttacagaa tctactactg gagataaaac
     3241 cctttcaaaa gttttagaaa atcccataat aaatcctatt ggaagcccaa acaataatgc
     3301 atacataaaa cctttaagta ctctctgcaa tgttataaaa agattagtga ctgtctctgc
     3361 atctgtcaca cagaaaaaga aaccttttat tacatctact ggcattggaa gtaacaaaga
     3421 actccctata tcttttgctg caaaatgcca gactaaaaat ataataacta atagtattat
     3481 tttatataaa atatccatac taccatcagt ttttttctta gttaatctat cgcttttatc
     3541 tttagaaatt ttaatttcca attgcttatt tcctccatat ctatatttct tatattcctg
     3601 tactctttta atactttctt aaatgtagct ttattcttta aagcatcaac acttttattg
     3661 taaagtgtta taaaatcact atatgcttta ctttttttaa actctttatt tacaactaat
     3721 acataggtat cataatctcc taatttagtt gtagattttc ttttaccctc taacccaatt
     3781 gactttatgc aatctattac aacaccatct actaaattac tttctaatcc atatgctagt
     3841 gcagtcccta ataagggagc tacttccaca ttcttgtagt attttttaac caattctgac
     3901 tggtaatctc tattttgaat gactcctatc ttttcaggat tattatcact taatagaaat
     3961 atatcagaat tttgaactac agtaccaaca atttcaaatc cactatttac atttacatat
     4021 tgttttgcag catctttaca tatgattgct atatctattt cctctgaact cagagcccac
     4081 tgcattgtac ttgctcagca atcattaatt gtaaaaatat ccattatatc acttactttt
     4141 atattttcaa agtagtctct atttaccata taatttatta caaaaccaga ggtatcatca
     4201 gataccccta ttcttaattt tccttttatt tcttctttat cttcaaaatt aaaaaatatt
     4261 ataaatatac ttcccaaaat aatgataaaa agtattatta tatttttcat attctccatt
     4321 tatttataat acctttgctt tccagtcttc ataactcata ccttcaggaa actctgggtt
     4381 aactttttct tttataaatt tgtcaaaatc atcagctcca caagagtcca ataagcttgt
     4441 atcaatcgta tcttcatatt taggtatatc atctaaagcc tttaaatctt tatacatttg
     4501 taaattattt ttatattctt cacctgtaac tttccaagta agagttctac cttctccaac
     4561 agtcttctta tagatagttc taagtgcaac ttcttcttct acattataat attttgcaaa
     4621 tattttagct gcttcagctg gatttgtata tatatattct attgcttttg tatgtgctag
     4681 aaccaatttt tttgctaaat ctggatgttc ttttataaag tttttgttta atgagaatga
     4741 acaacagtta tattctttgc cattagcttt ttctttatat tgagtagatg ctattatttt
     4801 tcctgcaccg tcattttcag ctacagaacc ccaagggtca caagatgtaa aagcttgaat
     4861 tttcccagtt ttaagagcta aatatttatc tttgtctgaa tccatattta caacttcata
     4921 ttttgatggg tcagttggta gacctgtttc tggaccataa tcacttgtcc ataagaaatc
     4981 actcatatct gttgcaattt ttttacctat taaatcttta ggttctttta tatcttttga
     5041 aactattaaa tattcagaac caccagtatg gttgttagct gctattgtta ttggcgaacc
     5101 cttaggtatt gctccaacta accccttagt tcctatgtaa cctgcatcca tttttcctgc
     5161 tgccatagct tcaggaactt taccatttcc aacagttttt acattaagac ctaaatcttt
     5221 atatattcct gccgattctg ctactggtcc cgcagtcata tggtcacaat tataataacc
     5281 tactgttatt gtataatcat cttttccagt ttttgcttct tctttttctt ttggtttact
     5341 actacatcct gttaatatag atgtacccat tacaccaaat aagattaatg cttgaatctt
     5401 cttagataat ttcatataaa tttcccacct ttatgtatta tttttatttt tagcaacatt
     5461 tgtccatatc ttcgccaaat aaatcaacaa attttttacc ctctactctg taaatagcat
     5521 atcctacatt accattttta gaccctgata caattacttc tattggtgct ttatcatcaa
     5581 tatttttaaa ggttatcgtt tgattctcta taggtgctgg tattggcttt gttatatagt
     5641 ggctattttt atcagaaact acgactacca tttcatttga attattgctt tttttatata
     5701 taactactaa atcttttttt ccatcattat ttaagtcttc ttcagcacaa gttattatgt
     5761 cttctttata attttttcta aaatattcta atgtttcttt attcacattt ggaatagaag
     5821 catcttcttt gatgttatca tcaactattt ttgataaaat gattaacaca actactatac
     5881 aggatattat aactatcttt ttaagcatga tttcctatga cctctttcat ctttggtatt
     5941 attgatttaa atgcaaataa aataattaaa atagtacata catactcaaa actatcaggt
     6001 atatttaaca ttagtttatt tgccaactgt attgaagaat ttgttgcatc taaatttact
     6061 gagttattat tcactaaaag taaatttgtt atatatccaa ttattattga agacagtgtc
     6121 aaagttacag aatatataat aacagttctt tttccaataa gtttaaacat acttataagt
     6181 tctggtagat ttgtagctgc tccagctatt agaaatgtta tcgctatacc aggagatgct
     6241 ccacttgcaa caagggctgc tataaacggt atatgtccta cagcacatac atacataaca
     6301 catgcaagta ttgctatact tccaagagat agcaaacctg gatttcctaa atatttttga
     6361 attatactat ttggaaaaat agttgttata aatcctgcaa aaaccatacc cattactaca
     6421 tatttactaa tagtaagggc taattcacca aaagaccatt taagaccatc aatcatattt
     6481 cccataaaac ttcttttttc ttcttctaat tctattactt cttcctctga atcattatga
     6541 agtgataatt cttcttttcc aaaacaattt cctaaaaatc ctactaaaaa tggtactaaa
     6601 aaaccagcta ttagataaat gattgtaact ttaggaccta aaagacctag acaaagaact
     6661 acagctattg gatttattat tggagttgat gtcataaaag caagtactgg tcctaaatat
     6721 gctcctgaat aatacatact tattccaagt ggtattactc cacaactaca tattggtaaa
     6781 aacattcctg agatagtact tttaattaaa gaagaaaatt tcttatttcc aagttgtttt
     6841 tgaaaccttc ttggagttaa aacattgtga agtacacctg ccaatataaa acttatcata
     6901 agccatcctg atgctccatt cagtgtaact atagaagcta ctatagtatc tttaactcca
     6961 tttaaaacaa tttctaatat attcattttt gatactccta atttttaaac ttttaattat
     7021 tgtttatagc ttctactatt gccctttcaa ttgtatcttt atttaatcta tcatatttct
     7081 ttttctgatt tattattaaa gttccttttg ttataatccc atattttttt atatacgaaa
     7141 aatctttccc tgcttgatat aattttattt ccaatttatc agcatatttt tctgacattt
     7201 tttttataaa cactccatgt tcatcacaag atggtcaagt gtttataaat tcaactaaaa
     7261 ttttagacat ttgttaatcc cctactttaa acaatttatc ttttacttaa aataatccac
     7321 agaaaataaa tttttctatg gattgtatcc tatactaatt tataacgtta taacttggtc
     7381 cacacctgca ctgcctaaac aagcatatag gtttgggaaa catccaattg tagctccatc
     7441 aaccaaatta ttctctatac ctctttctat agcacattgg tcacaagcca ttattatcat
     7501 atcagttttt tcatgtaatt tacttagtct ctcgcctaca ggattacctt tagataaaaa
     7561 taaggtatta tccataaaga aaaacatccc tagaacgtct actccatgag ttccttgttc
     7621 aagttgtggt attatcattt tgtctagaat tttatgtgta ttagtactac taaaaatata
     7681 agctactttc atttttattc cccctatact ttttatattt tacaaaattt tacagataca
     7741 attatattat aagtttattc ttatttatct gtaaaataga tattaactat attattaaaa
     7801 gtgtatatag tatttatcta tttttattaa attattgatt gatttttttc tatttttatt
     7861 aattttaatg aataaaaaat agactcctta aatttataaa acaaatttaa ggagtctatt
     7921 ttaattaagt ttatttcaat ataaaattta tatatttctc aaattcttca tacttatatc
     7981 gagagcttta acagaatgtg taagcgctcc tacagaaaca acatccacac caatttttcc
     8041 tatatcttct atagtatcta aatttacatt tccggaaaat tctacaatgg ctcttccatt
     8101 tataatatct actgcttgtt ttgccatttc caaactcata ttatccaaca ttattatatc
     8161 tgcattagct tctattgctt cttttaccat gtctaaagtt tccacttcca cttctatctt
     8221 tctaacaaaa gaagtatttt ttctagctaa ttcaactgcc ttcttaacac taccagcagc
     8281 cccaatatgg ttgtctttaa gcaatattcc atcagataaa ttaaatctat gattgcatcc
     8341 tccacctact ttaacagaat acttatctaa tattctaaga ttaggtatcg tttttctact
     8401 atctaataat tttgtatttg taccttcaag cttttcaaca tacctacttg taatagtagc
     8461 tataccactc attctctgta aataattcaa tgctacacgc tctcctacaa gtaagtttct
     8521 agtactacct gttaatacag ctatcttttc acgattcttt actctatcac catcattttt
     8581 atataatttt acatctacat caccaagtat ctcaaaaact ctcttaaata cacctaagcc
     8641 agctattata ccatcttgtt tacaaattaa atctacagta gatttagaat tttcatccac
     8701 aatagaatta gttgttatat cttcacttgg aacatcttct atcaaagcat cctgtatcat
     8761 tctatcaata atcaaataat tcatcgccaa aatcctcact tgttctttca atttctttta
     8821 tgactaatat tttattttct ttttttacct gttctatatc tatatccata tctggtacat
     8881 ctataaactt aacttttaca ttatctataa ctgagtttat atttttagct gctctttttg
     8941 aaaatacaag cccttcaagt aatgaattac ttgccaatct attggctcca tgaacacctg
     9001 tacaactaat ttcaccaact gcatataaat tttccataga tgtttttgaa tccaaatcta
     9061 catgtatccc gcccataaaa taatgttgtg caggagatac ctttatacat tctttcgtta
     9121 tgtctgttcc tctagctaaa cattcattat aaataaaaga aaatctatta attaaatatt
     9181 cactatctaa atgtgttgca tctaaataca cataaggtaa tttatctttt tccatttgct
     9241 caaaaatagc ttttgaaact acatctctag gaagaagttc atccacaaat ctttctttat
     9301 ttttatttaa aagtttagct ccctctcctc ttaatgattc agatataagc attctcctac
     9361 cttcattatt ttcttcataa aaggctgtag gatgtatttg aatatattct aaattttcta
     9421 tttttatatt atttcttaaa gctattgcaa ttccatcacc tgtaagatgt ctttgattag
     9481 tagaattttt aaaaagccca ccaattccac ctgtagctaa aactactatt tttgaaaaaa
     9541 catgaatctc ttttttagat ttaaaaattc tagctcctat acatttattg ccatctttta
     9601 atatatctaa aagataggca tcttctataa gagttatatt ttctctagtt ttagcttctt
     9661 ttaataaagt tttaaaaaca acttctccag tattatcctt actatgaact attcgattta
     9721 cactatgtgc tccttctctt gtgtaatcta tctctccatt ttctttgtct aaaggcatac
     9781 catattctac tatctgccct acattttcta tagattcatc tgcaagtact tgaactgctt
     9841 caactctatt tttatactgc ccagccttca ttgtatcttc tacaaaggat tctatatcat
     9901 caatatttct agcagttgaa attccacctt gtgcaagata tgtattgttg ttttcaattg
     9961 ttgatttcga tactactagc acatttaaac ttttatctaa atttaatgca cagtataatc
    10021 ctgaaactcc acttccaact attaaaacat cttgttctaa attcataagt ctatccctct
    10081 atccttctgc taatttgtgc atgttaagca gtgaatttaa agccttttcc atgatttcat
    10141 cttctacaat aacttcattt tccatatttt taagtgtact atataaattt tctaatgttg
    10201 tctttttcat atctgtacat agtatttttc caccaggaat ataaaagttt ttattaggat
    10261 tatttttctt taattcatgt aatatacctt cttcagttgc tattataaag tctttgtttt
    10321 tactattagt agcatatttt attattcctg atgtactacc tacataatct cctaaatctc
    10381 ttatttcttt tttacattct ggatgtacta atacttctgc atttttatac ttatctttta
    10441 actcaattat ttcttcagct cttatattgt tatggtattt acaatatccg tcccaaaata
    10501 taaagttttt atctggaaat tgttctgcaa tatatcctcc taaattttta tctggaagga
    10561 atataatttc tttattatct atgttttcta gtattttaat tgcactagaa gatgtaacag
    10621 aaacatcaca atgtgcctta actttagctg tagagtttat ataacataca accaaagcat
    10681 ttggatactg ttgttttaat tttatcacgc cttcttcatc taccatatct gccatagcac
    10741 acccagcgtt acttactggc atcaatacag ttttttcagg tgataatatc ttagcacttt
    10801 ctcccataaa ccttactcca caaaatacaa ccacttcttc tttacaatct ctagcaatct
    10861 cacttaaata atatgagtca ccaactgcat ctgctaattc ttgtatttct ggtggttgat
    10921 aaaaatgggc aagtattatt gcattttttt ctttctttag ctctttgatt tgatatgtta
    10981 aatctttatc cataattgca ccgctttcta tatgtactag tgtatataca cctgtaaact
    11041 cattatatca cttgactatt ctttcttcaa gaattttaaa cctcttaata ttgttaagat
    11101 atagacattt atattctcaa ttgattttcc ttttttctcc atctatttaa actaattttt
    11161 atatttttta atttttttgt aaaatattat cagaattttg tctatattct ttattgctat
    11221 aacattgaaa atattaccaa atacctgtat actaagtaca tggttatgta tatgtattta
    11281 tttctgaaat tatattagtt gtaatacttt atagaatttg taggttgtcc agaattaaat
    11341 tcaatataaa tctacacatt tagataatat gtatacaaag accaaaaaat tttataaatg
    11401 gggtgatatt atgacaacat tcttaatcgg cttggctata ttactaatag gaggtgcttt
    11461 atacggtgct tattgtgaaa aagtatttgg cccagatgac agaaaaacac ctgcacttgc
    11521 tcaaagtgat ggagtagact atgtcccaat gaaaaaatgg aaaaatagtc taattgagtt
    11581 gcttaatata gctggtacag gaccaattct aggacctatc caaggtatat tgtttggtcc
    11641 aatagcattc atactaatac ctattggctg tgtatttgga ggagctttgc atgactatat
    11701 gagtggaatg attagtataa gagaaaaagg agcacaaatg ccttctctta tcagtagatt
    11761 tttaggtaat aaagtatttc aagtctataa tatattcctt tgtcttttaa tgcttttagt
    11821 tggtgcagtt tttatttata cacctgggga tttagttgtt actcaaattt taaatatgaa
    11881 atcgactata aataatccag ttgtctggat agtttatgga cttatctttc tatattactt
    11941 gtgtgcaaca ctatttccaa ttgataaaat cataggaaag gtatatccaa tatttggagc
    12001 tattctactt ttatctgctg ctggtgttgg aattggaatc tttacacaag gttatgattt
    12061 agctaattta agtcttgcaa attggaaagg tattcatcct gatggtattc ctcttattcc
    12121 tacattcttt gttacagttg cttgtggtat tgtttctgga ttccactcaa ctcaagctac
    12181 tcttatagca agatcagttt caaatgaaaa agaaggaaaa actacttttt ataatatgat
    12241 gattttagaa ggtttaattg caatgatttg ggctgcagct gctatgggta tttacaataa
    12301 aggaatacct aaggaattag taggttctcc tgatgtaata ggtttggttg caagagattt
    12361 acttggttct attggtggta tcatagctat aataggtgta attgttttac caataacttc
    12421 tggagataca gctttaagat ctttaagatt aatgcttgca gattactttc attatgacca
    12481 aaaggaaaaa aaacatcgtg ttatattgtc aatctgtata tttattcctg tcatagccat
    12541 ccttatattt gcaaagctta gtgcttctgg atttaatata ttgtggagat acttctcttg
    12601 gagtaatcaa actattgcca tatttgcatt tgcaatgatt acagtttacc ttataataaa
    12661 agaaaagaat tatattataa gcttaattcc tggtatgttt tattcctttg ttatattcag
    12721 ttatatattt aatgctcaaa ttggatttaa cttaaacata aatatatcat atgttttagc
    12781 tgccatattt actgtattat atgctatttt aactgtacgc tctggtagaa agttaaaaag
    12841 caaagcagat actaagttgg ctgactaaat ctaaataaaa taatacttag aataaatttt
    12901 attaaaaaat gataaaaaag taggcaatct caagttagat ttgcctcttt tttatttaat
    12961 acagtaataa atacttaagt atttactcct tattggaata tttatcctaa atctctaata
    13021 taaataaata aaagttttaa aataatctat tcgtttatat acttaaaata aattttttgg
    13081 aggaatactt atgaataata aattacatga acttgaaaaa aatctaccag aaacatcttg
    13141 ttctttttgc acacatcttt catttaaggg gcctagccta gactatagat atgatattag
    13201 atgtgttatt tcagatacaa agcccgattt tagaggatgt tgtgaatatt ttgaaccaga
    13261 atatacagaa ttaaatacag gagatttaga caatctatac ataaactttc ttgagacatg
    13321 cctcaaggta aattataatg attacatcaa ttctatgtat tggaagttat ttaaagaaag
    13381 aaccctacta gaaaacaatt ttaaatgttc tatatgtgga tcaactgaaa atgttgatgt
    13441 gtatcatgtt aataaaaatt taggaaggga aacttccaaa gatgtagttg ttaaatgtga
    13501 taaatgtaat tgtaaataag tgtataaaat ttagataact tcacataata agtttaaata
    13561 aaacttagga ggttatttat gaaaaataat aatttaaatt gtgctgctac taattgtgct
    13621 tataatacta gtggatattg ttatgctggt agtataaaag tagatggaat gcaagcaact
    13681 actacagaaa atacttattg tgcttctttt gaagacaaat atacatctgg tataactagt
    13741 cgttctaatg aaactaacca agttgataca gataacattc attgtgaagc tgtaaaatgt
    13801 aaatacaata aaaatgaact ttgcaaagct gaaaaagttc atataaatga aagaaatgca
    13861 agttgtgaaa cttttgaaat gaaataaatt tctttttatt tagttttata gtatttatac
    13921 aaagcaaaat tgaacctatc aaatagatgt ctttattaat gatgtctatt tataggttct
    13981 tttttaaaac aatttataat ttatatataa agataaatta ttattttaat atattaccta
    14041 gaagtaaatt taacacccag aatatccata aggaacataa atattggaac tccaattagt
    14101 aatccccata cacctaaata atgttctcct acaagtaaaa taataaaaac aaaacaaact
    14161 ggaagtttag ttctattcga catcaactta gggtttaata tgtatgtttc tactgcatgc
    14221 actatacaaa tcataagtaa aactccaaaa acctttgtta ttcctcctgt attaaatgct
    14281 attacagtta atggaatcaa agacactata actcctgcta ctggaataag acccaacaca
    14341 aaaatcataa atcctaaagc ccatatttga gggaatccca tgaaacctaa gaaaatcata
    14401 gaaacaacag aatttataaa ggcaatcata acttgtactt tcattacttc accaaaattt
    14461 ttaacaaagc tctttccaaa aaatacaagc gaattataaa taaaagaaat cttactatca
    14521 gaaagtttat ctccaaaatt tttaatttca tttttttcaa gtaaaaggag taaactcagt
    14581 aaaaatgcca ataatatatt tactccaaaa cttccaactt ttgttgctgt tgatgctata
    14641 agtagccctg cttgtgaaat atatttatta aaatccagct ttgagacaat aggatacaat
    14701 tttggtccta aagattgagc aaattgattt acatcaaaat cactaaaaac cctactcaac
    14761 tctgtaagtt gaactataat tattggtaca actgcatagc taatcaatac taacaatata
    14821 gcaaatagtg catataacac tataattatt aatgaatctg gaatatttaa agaagaaaac
    14881 ttcttaattc gttttcttgt ggctacaagc aagttataga aaataaaagt cataataaat
    14941 gttaaaagca ccatatttaa catataccaa aatgtaatta gaataattac tacgacagat
    15001 atagaaacaa ttttatattt tgaactgtca cgtgccaatc ctttgttatc ttccatagtt
    15061 taaatcctcc ccaaattttt atgactttat aatgactgcc ctttttattt taatctcaaa
    15121 aaacaagtag aaaaatacta aaaataactt attaattttc ataaaacaat attaaaattt
    15181 agagaagata cattttaaat aatcttactt atactgaaat ctgctctaca tcatatattt
    15241 aatttattat tatctatctc atatagcaat tcgtatatct ctggatattc aaaaaacaaa
    15301 ccctctttta gtaattgtct tatttcatct gtgcttaccc actttatatc acttacttct
    15361 tcctcctgta aaatagcttt ggatatatca tattcttttt taactaagta tacatcccaa
    15421 agagtatctt catgaatcat acttctaaaa actttcatct catctttagt tatatctatc
    15481 cctatttctt cctttgcttc gcgaattgct ccttctaaac tgtcttcccc agaaacaata
    15541 catccagttg tcattcccca catatttggc aatgtctttt tacttttaga ccttttctga
    15601 attaaaattt gagagttact atttaaaatc cacacttcaa ctgccaaatg gtaataacct
    15661 tcttcaatag aattacctct ttttataaca tttcctgttt taattccatc agcattatat
    15721 aaatcccata attccatttc aaaatctcct tgactttact ataaattaga taaactacaa
    15781 atatatttta gcataattaa ttctgctcat tttttattac aatacttgat ttacatttat
    15841 gttcattgct tttcttttcc ttccattctc ttatatcatc tataataaat ctatgtttca
    15901 acaattttgt gtcaaattta aatattctaa acactatttg taatacatat cctaaaccta
    15961 aagcacttac aagcgtacca atacctacag aacctcctaa taaccaccca acaactaatg
    16021 ctagtatttc aagaattgtt ctaacaagac gtacagattt attagttttt ttctgaagag
    16081 caatcataag cccatctctc ggtccacttc ctaaacaaac acctaagtat agaaaacttg
    16141 ctatagctgc caaaataatt cctataacaa ccataaacac acctatataa gtgttgcttg
    16201 catgaggtat cactccagaa aatattacta aatcaataaa aattcctata aatgtcatgt
    16261 tgagtaaagt accccatcct atattttcac caaaaactgc atccaatata acaattacaa
    16321 ctcctaccat tatagaagcc tgacctatag ttatgcctag ctttatagat aaaccttggt
    16381 gaagtacatc ccaaggcata agacctacat gtgcattaat cataagcaca gaagaaattg
    16441 caaatataaa aaaacctgaa aataatctta tcatactttt taaacttatt tttcccatca
    16501 aaaatcactc ctcataataa taataacaat aaataccaat aaaatatata tataaatacg
    16561 aaattttaca gaattattta ttaggttaag ataaaatttt aattataaaa agtggcaatc
    16621 caaattttat acattttcac ctatactcta agctttcgtg tataaaaaac ggatatacca
    16681 cttttttagt atataaacat ttttagtttt tcttattaat tttcactata aattctagct
    16741 tcttcttctc catttagtac tcttaaagtt ccaaaagcaa gtgattccaa ctcattttct
    16801 cctgccataa tttctactgg tgctataaac tcaactttct ttttaaccat tgaagtaaac
    16861 atttcagaat atgcaattcc acctgttata attatagcat ctacctttcc atctactaca
    16921 gttgctaact ctccaatacc ttttgctaac tgataagcca ttgcttcata aataattttt
    16981 gcttcttcat ttccttctgc tatcattttt tcaacttctc tagcatctac agtatttagg
    17041 tatgaaacta taccaccttt acctcttatc tttttagtca tttctctttc tgaatattga
    17101 cctgaataac aggcagccac taattttgta gcaggtactc ttcctgacct ttctggagaa
    17161 aatggtcctt catcatcaga tagcatatca accattcttc ctttttcatg aagataaata
    17221 cttactcctc caccaatgtg agctactatt aagtttaagc tcttataatc ttttccttta
    17281 tccttagcat attttaaagc cattgctcta gtatttaatg catgccctgc acttgatcta
    17341 tccattccac aaagtccaga tattctcgct acatctataa gctcatctac tgcaacagaa
    17401 tcataaatat atgagttgat tccaagaggt tctgatattg catgtgccac aacagcacct
    17461 aaattggaag cgtgttcaag tactggtcta tgtcttagta catcaatcat ttcttcattt
    17521 actaaatatg ctcctgattt tactggtggt aaaactccac ctcttcctac tattgcacta
    17581 agagatttta agtctatact attttcttta agaatattca aaactgcttc cttacgcatt
    17641 tcaaactggt cttgtatagt attatatttt gcaatctctt cagctggatg gtctatcgtc
    17701 ttcacaagaa tttgttcttc tccatcatat actgctattt ttgtagaagt agaacctgga
    17761 tttatggcta atattctgta agtcataatt ttcttccttt caccttaatt tctatagtct
    17821 atttatatct attataaact atttgctaac catttccata ccttcatgga aagcttttat
    17881 gtttaattca acaaattttg gtttaacatt ttcacttata attttttccc aatcaataga
    17941 ctctaattgc atagatttaa ctagacatcc taataaaata acattcatta tttttgaatt
    18001 tcctagttct tcagctttat cagctgcatt tataactttt gcatttaatc tacttaactc
    18061 tgcatctata tcactttctt gatattcagc tcctccgatt aaaacagtca tagaatctat
    18121 cctatgatta ttcactaaag cttttccttc tggttttaaa taattgaacc atcttaaagc
    18181 ttccattttt tcaaaagata ctaatatatc tgctccacca atttctataa ctggagaatg
    18241 aacacaatct ccatatctaa cttgtgagga aactgaacct cctctttgac tcattccatg
    18301 tatttcactc atctttacat catatccagc ttccatcaat cccatagtta ataatttact
    18361 agcaagtata gttccttgac ctcctacacc taccaaaagt atactcttag tcatattatt
    18421 tttcctcctt aactattgct tgttttggac aaacttgtgc acatactcca catcctacac
    18481 actgatttct atctatattt gataacttat tctctttatc aaatgataga gctggacatc
    18541 cagttttcaa acataattta catcctatac atttatcatg gtcaacttta cacttagtct
    18601 taaatggatt attaaattct tctatatctt ctttagagaa ttttttaagt acacatggcc
    18661 atcttgttat tattactgat ggttcatctt ctatagctaa agcccaatct agtgcttcat
    18721 ttacttcttt taaattatta gggtttataa ctcttacatg ttctattcca caagctttaa
    18781 ctaatccttc tatatcaact tctttagttt tagcaccttg taaagtatat cctgaacctg
    18841 ggttttcttg gtgacctgtc attccagtta ttctattatc taatataacc gaaatagaat
    18901 tacctctatt gtaaacaaca tctaaaagtc catttattcc tgtatggaag aatgttgagt
    18961 ctccaagtac acctaccaat cttttttcat tatcatcctt catattaaga actttttgag
    19021 ctccatgtgc agttccaaaa gcagaaccca tacaaacaac ataatctatt ccattatatg
    19081 gaggagcaaa tccaagagta taacaaccta tatctccacc aactattaaa ttttttctct
    19141 ttccaagttc atagaagaat cctctatgtg gacatcctgc acagaaactt ggtggtcttg
    19201 gtgttactaa ttcagatttg tattctatag tatcatttgt ttttccaaat atagcttttc
    19261 ttaaaacatc tggtgtcatt tctccatatg gtggtattac atcttttcca atacaatcta
    19321 ttccatatgc ttttatttgt tcttctataa atgggtcatt ttcttctata acatatattt
    19381 tatcaacttt ttctgcaaat tcttttattt tttcataagg taatggattt gtaaatccta
    19441 gtttcatata tgatgcattt tttccaaaaa cttctttggc aaaattacaa cacataccag
    19501 atgctataac acctattttt gtatcattta tttcatagta gtttaaatca gtttcatttg
    19561 agaatttttt aagaatttcc attctttctt caacaacgcc ccttcttatt tgagcatttg
    19621 ctggaacagt taccattttc ttagcatttt taacatactc tttaatttca acttcttctc
    19681 tatcatagca ctccactaat ccttttgaat gacaaagtct tgttgtaact ctatataaaa
    19741 ctggtgtatc gtatttttca ctaacttcaa aagcttcttt tatcatatct ttagcttctt
    19801 gactagttga tggttcaaat aaaggtatct ttgcaaattt tgcatacatc ctattgtctt
    19861 gctcattttg agatgaatgc attcccggct catctgctgt aataagtacc ataccaccat
    19921 ttacccctgt atatgcataa gtaaatattg gatcagctgc aacattcaaa ccaacatgtt
    19981 tcatagaagc cattgttctt gctcctgcaa ttgaaccccc tatagcagcc tcaagtgcta
    20041 ccttttcgtt tggagcccac tctgcaacta ttgcatcttt atatgttgct atattttcta
    20101 atatttctgt acttggagtc cctggatatg cagatgcata tttaacacca gcctcatagg
    20161 ctccacgtgc aattgcttca ttacctgtca tcaattgttt catataaaat tccctccatc
    20221 tacaattatt aaattcatag tccacccaat ttgttcaatg aaattaatta tttattttta
    20281 cttctaaact ttcaagtgct tcttttataa tacttggtgc tttcttacat ttatcttcag
    20341 aaactgcaca aactgcaaat cttaagccca tttttaatgg aactgcaaat aaattatgtt
    20401 tagtcaattc ttcacatact tcttttggat tatcacatgg tatacttaca aagaaacctg
    20461 ctatatatgg aagaatttct aatcctactc tttcagcttc ttttacaaat acatctgctc
    20521 ttctagtaag catgtttttg tatatttctt tttcatcctc atattctttg aattttttag
    20581 ggtcatttac aatgttagat aatactgcca tagcacttct attacaattt gaccaatttg
    20641 ctctacatga atgaacacat gagtaatgga actcttcagc tacatcttca cttgaagata
    20701 tacaaattat agctcccatt ctcataccat aagctgtaaa tccttttgac atactgaatc
    20761 caaccaatac gagaacgttt tcaggcaaat tagaaaattt cttaaaaaac tttctacata
    20821 catcatcatc acctgcaaag tcaatatatg ctgaatctac gaaaaatatt atctttttgt
    20881 ctttatcttt tgcgacttct tttgataagt ctaatatttt atcccactca tcatctgcaa
    20941 cactatatcc agttggatta tgcgctggtg tgtttataat tgtaaagact ctaccttgtt
    21001 tttctgctat atttacaaat ttttctttaa acgactcaaa attaaacctt ctattttcat
    21061 caaaaagttg gtaattaact acttttctat tagcctcttc agctatactt acatatggac
    21121 tccagaacca atcagatgtt aatacctcat ctccttcatt agtatagttc catacagcta
    21181 attttattgc accacttcct cctggtgaag ctaatactct tatatgtcct tctggtaagt
    21241 aatctctgaa aaatactttt ttaactgctt ctaagtaatc tggttgacct tcaagagctg
    21301 catatgcacc tatctcacag ttatctaatg ctttatattc ttcatataca gttttcattg
    21361 ttatcaattt tcctgaatca tccattagag cgcctattgt tgcatttatt acattatcca
    21421 taccaaaagc cttctctgct gcttgagctc tgccagatat gctaaatata acatcatttt
    21481 cttttggcca cattgcatgc ttaccaacca tactttgact cataccatca cccctaaaat
    21541 tgtatttact cttacattat atattaagca attactatgc caataaatcc cactttatgt
    21601 aaaattgatt ttgtttagaa ttattatttt tttcattatt aaattaagtg ttttaactat
    21661 ttttcttata aatatatatg cctgtctaaa aaaataaaaa tttgcaaaaa agtaatgtta
    21721 atttttctta acacttgttt taaaaaatta acattacttc aaaataattt atatgtaatt
    21781 atatttaaat atttttattg tatttcttcc ataaagatgt cctgcttatt ccaagaactt
    21841 gtgcaacttc atttttagaa agtccctgag caaaaagcat acttattatt ttttcttcaa
    21901 catacttatt tacttctttt atatctatac ttatcttacc atcatttatc ttacttatat
    21961 ttatagattc atcttggact tctacacttg ctgtcgtttc agaattaaat ttgtctactt
    22021 cagagttagg aagtaatttt ttagttttaa aatctctatc ttgtctcaat ttaattttac
    22081 ctgtcacaac atatttttga gctattgtct ttaactctct tacatttcca ggccagctat
    22141 aattatatag cttatccatt tcatctttag tcaaaacaaa attttcatct atactgttta
    22201 ttccattgag accatcatcc tttaatactt catttacaaa attgttaaac aaaggtatta
    22261 tatcttctct tctgtctctt aaaggaggta tatttatctc taaactactc aatctataaa
    22321 ataagtctgc tctaaatgta cccataacta ttttttcggt taaagattca ttcgttgctg
    22381 ctataatcct tatatccaga ggtattatat aatcagaacc aattctcatt atttgacgtt
    22441 cttctattac tcttaatagt tttgtttgaa tattaaagga tagactattt atttcatcta
    22501 aaaaaagagt ccctccatga gcaagttcaa atagtcctct ttttccaccc tttctagcac
    22561 cagtaaatgc accttcttca tagccaaaaa gttcactttc aagtaaattt tctgctatag
    22621 tagcacaatt tatagcaaca aaaggcctat cttttctttt acttatgttg tgtatactat
    22681 gagctataat ttctttacca gacccacttt ctccataaag taaagttgta taatcacttt
    22741 ttccaatttt tttagcttct tcaataaatt ctttagttaa tttatcttta aataaaaaat
    22801 catcaaaagt atatctagca tagagacctt tttgattcaa gtcaaatctt atttttcttt
    22861 ctaagttttg tagcttggtt atatcttgta ttattcctaa aactccataa gtactattat
    22921 caacttttat caatgttgtc ctagtattaa caattagatt atttatattt cttatctttc
    22981 tatcttctac gtcctctttt tcatgtaaac aatctaacat ccactccatt ttaggaaata
    23041 catctaagat gtatttatta agtgcacatt ttctctctac tttaagcatg ttttttgcac
    23101 tttcattgta caaaattata ctgccattac tatctatagc aattactcca tcttttatac
    23161 catcaagtat atttcgtaac acttcattat taaacttttc ttcacctaat gtatctaata
    23221 attttttaca atattctaca gcttctctta tagattcatc actagcagtt gcaaatacac
    23281 tatcaattcc atattgcctt gcaaaagaac atgccaaacc tcctcctacg attacaactt
    23341 catctttttg gtctatatat tttacaactt tacttcttat ctcatactta gattcaaacc
    23401 attcttcagt tatttcagta cttatgacat ttctccagcc aacatagtca aaagaaactt
    23461 cattgtctcc aagaatcaat actacttttt tagaatattt ctttgctatt tctattgctc
    23521 ttaaaaggtc agttgacttc atattcattg gtataacagg tacatttact gtatctatta
    23581 ctaagctata acctccacct ctaccaatta tagcttgggc acctttttca acaagtatac
    23641 gaccttgatt ttccattaag tctaggttaa gtatgtcgat tattatagtt ccattttcta
    23701 catcttctct atataattct tctattcttt cttttaattc aatatcagag gctataattc
    23761 ctattttttt tcgcaacaaa atcacctcaa ttttaaatta taatgtattg atttctacct
    23821 gctttttttg atttatatag gttcttatct gcatcttcaa ttaatatttc aacatctttt
    23881 ctactacgac acctttttat acttactcca gcacttatag ttatatagtt ttttatttta
    23941 gaatatatat gttcaatacc ctcaaattca agaagtttga aaactctttt aatatataat
    24001 tctatattat caatctcttc aacaccgatt gattctatag aatctactaa tattaaaatt
    24061 tcttctcccc catatctgat tatgtgttcg gtaatatcta taaatacact tcttataata
    24121 tcagttacct taactataac tttatcccct gctagatgac cataattatc attataactt
    24181 ttaaaacaat ctatatcgac cagtattgcg accatatttt tgtctctggt tccattaaat
    24241 aaatccaact gctgttccaa atatcttcta ttatatagtt tagtaagtcc atcttttaaa
    24301 atatcatttt ctaatttctt attatcatcc actagtaatc ttaaactctc ttgtttttgt
    24361 ctgagttcat attgtttgtg aattgcttga gatgttttat aggaattatt tttttcccac
    24421 ctatcagaat accaatccat acttttataa tattctattg ccagtttaaa atcttttttt
    24481 agctcatatc catttgctat tagcccatat aaatatagat atttttctaa gattcaatga
    24541 actcttttta actaaattta aaccttttat ataacaactt ataccttcat ctatattacc
    24601 aaattttata tataaatctc catacaactt atatatgtaa tctagtttag aattatatat
    24661 aaaaacatct ccaaaacttt tatatatatt ttttgataaa attaaatagg tgtttacctt
    24721 ttcaaaacta caattatctt tctttaactc aatttcagct gaatataaaa atataaatga
    24781 atataaataa tccttatata caccttcaac aactttcatt aattttatag tctttaataa
    24841 aataacttct gcttctttat tcatatcttc ttttaaatat gcccatataa ggtctatttt
    24901 tatagacact ctttcagtta ctgatattga gttattactg tgtgcaacat ctaatacatt
    24961 atttatgtat tttatagctt ctacattatt tccactctct aaataacaca aacttattat
    25021 acatttacaa aaagcctcta tagagtataa attattttct tgagccaatt ttagacattc
    25081 aattaagtat tccatacttt ttataaagtt attaaataaa tatagataaa ctctcccaaa
    25141 tatataattt gccctactta caagagcttt attttttaaa gttttaaaaa aagacacttc
    25201 ttctactaaa gctattacat ccgttttggt ctgatataaa gcacttattt ccacacataa
    25261 actcatattt aacaatacca acaactcatt taaatgattt tgccttataa ttttttttgc
    25321 tgagaaataa aaattattta ccttatcata ttttcttata gaaatagctg ataaagtaag
    25381 ataaatataa attttagata ttatatctga atcatctttt aatgacaatt ttttaatata
    25441 ctttaatgac tctatcaaat agttgtatga tgcttctcta tcttttttta tatagtttat
    25501 aagactaatt aaatataaag tatagactct actattatct tctaattttg tatttaaaag
    25561 gtctttgtga taatccaaga tgtagtttaa atctgtcaaa tttagataga atttagtcaa
    25621 catatcgtat tctatcttgt ttatatttct ctttaaatct tctattaaac tccttttcaa
    25681 gtaaatcacc aatcctattt caacagttaa aaattcttaa aatcatgata atgcaaacat
    25741 ctatttctac cactttcctt tgctttatat aaagctttat cagcattttc aattatttct
    25801 tttatatcta tactactatt tttacatgta tcaatgccaa tactaactgt caaattatta
    25861 tttaaaaatt tctttacaat cctac
//
LOCUS       DAEHWM010000051        25632 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.052, whole genome shotgun sequence.
ACCESSION   DAEHWM010000051 DAEHWM010000000
VERSION     DAEHWM010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25632)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25632)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25632
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.052"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(122..490)
                     /locus_tag="KNP36_002183"
     CDS             complement(122..490)
                     /locus_tag="KNP36_002183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0874052.1"
                     /translation="MKKIPKSELLVMNFIWDKDIDKIPAREVANYMEISHGWTKGTTG
                     KVLSRLSDKGFLEFEKDGRNTLYTIKVKHEEYLKFETKDFLELIHKNSIHSFISSLGC
                     GNEISDDDIKELEQWLKKRK"
     gene            complement(1018..1440)
                     /locus_tag="KNP36_002184"
     CDS             complement(1018..1440)
                     /locus_tag="KNP36_002184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3284 domain-containing protein"
                     /protein_id="HBF0874053.1"
                     /translation="MNTFKTEVLLKYSAKDIFNIFTKSARLNFPNFNEKKAVGTFVQQ
                     KNNKRFKVEITNFEKNRVYEIKTSNKRESTITRYELVHIDLENTKLIFIESESKRNIF
                     GKINSALVRVLFGKRQPEEFNKFIKKLEMELENNSVNL"
     gene            1918..4821
                     /locus_tag="KNP36_002185"
     CDS             1918..4821
                     /locus_tag="KNP36_002185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0874054.1"
                     /translation="MELRDKLVNIINTENKKDPLTDVQIAKFLSTTRENITNLRKELN
                     ISNSRQRRYPYLKSAISAILQKNKNISISEITRELMTEGFNISRRVVEELLPKESLEM
                     DVVEEDEEESNDPFETLIGNKGSLRNAVEQAKSAILYPPKGLPTLIIGESGVGKSLFS
                     RHMYEFAKQKKIVKESSNFVVFNCADYSDNPQLLLSLLFGYKKGAFTGAEYDTPGLVE
                     EADEGVLFLDEIHRLPPKGQEILFSILDRGKFRRLGETNAERKVSIMLIGATTENVET
                     NLLLTFRRRIPMLITLPPLHDRLLKEKIDLIYNIFQQECNRINAKIFVDKNVIEILAL
                     KKFSGNIGQLQNMIQVLCARAFMKFINSKDEDSESIVVVDINEVLKLKDSFKDAAFQE
                     IEYTEIRKYLKNAIFIPFNLEESSVKGSLLSDEYILPEDIYKTIEKKYYDLKSLDIED
                     IDIENILWTFILNRFADLKFNLDSNEEIFSMSDLNSFVSDSLVKLVKELMNDIVEKNM
                     NLEVNKNMFKYLAIHLEEAIKRIKLNQKIINVNLEKIKIDFSKEYEISKSFAIKIEES
                     IGIKISDDEIGFITLYIKSALKNEVKKDKVGLIIISHGRIATETVNVVKELLGVKFPV
                     AIDMPLDEKPINIYNKAVELSKIIDQGKGILFLVDIGSLTNIGQIVNKRTNISTKTID
                     RVDLLMALEATRKVSMGEEELDEIFFSLLKDRMGYNYELEKHIDKSNAIITLCLTGEG
                     TAKYISKTLEEKYDNTKCYQMSALDESLFCKIENLKETNNILAIVGTINPKIPGINFI
                     PYNKELFKNLDIYLSKSKQQDDRPIKSYERMLDEDLVIFEPDIYFKKDLLEYVCSILI
                     NKEYVEKDYLDSVLHREEMLPTYSKGAIGVPHGDSSTVNSTRFVFVKLKNPIDWGVGN
                     VNFIFMPVFQANDKEIVKNVLEILKDAEFMNNANKCFDKDAFRRIIFDKFKHL"
     gene            4854..5300
                     /locus_tag="KNP36_002186"
     CDS             4854..5300
                     /locus_tag="KNP36_002186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0874055.1"
                     /translation="MNVDLISLGLESNDYESVIEELGSIMCKKEYVKETYINAVLERE
                     RTLPTGLDIGDMCVAIPHTDSKHVNESNVAVGILKNPVKFNSMIDPKDRLDVELVFLL
                     AVKNPDSQVKLLKDLMSVFQNIKLLKNIKNASTKEEVAKLLDFIEI"
     gene            5423..5725
                     /locus_tag="KNP36_002187"
     CDS             5423..5725
                     /locus_tag="KNP36_002187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0874056.1"
                     /translation="MKQFNVLSVCGSGTVTSSMVAGKLKEVLGNKGISITTTEARPTE
                     ALNLAQSGRFDFITFTSPLQTGDYGIPTINAFACLTGIGEEAFFEEVLTVIEGIDK"
     gene            5906..7312
                     /locus_tag="KNP36_002188"
     CDS             5906..7312
                     /locus_tag="KNP36_002188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBF0874057.1"
                     /translation="MLEFMKSIIDTFGSAIIVPIIIFIIAKIFKVTTKKSFLSAVYAG
                     VALQGFTLILNSFTPVITPVINRMVESTGVNLPVFDVGWQATSLVAFSTSAGMIYLGL
                     GILLQTILFLIKWTDVFQPSDLWNNYSYMVWGAMVIGVTGNFPLGIACMVLLNLYSLL
                     ISELVAKRWSSYYRYPNCTIIAMHNVEASVFAVFADPIYNKLGLNKIKLNPKELEKKL
                     GFLGEPITLGLFLGMFIGILGNMTRINTMEAWGEIMKVGISTSAVMAIFPKVASMFAQ
                     AFAPITEAARKIMQKAGNREWYIAVNDAVGYGEPATLISGLILIPIMLVIAMVLPGNK
                     VLPVVDLLAIPYMVQGLVAIHNGNIPKVLVSGIIWFGLGLYVCTSTAPLFTDMATNIG
                     VAIPAGAMLITSFNILGKPLMGLVFFAFLSANPIYIGLSVVIYFVLWALFRKNKTSIL
                     DYLEKQALKNVEEEPVAV"
     gene            7656..8714
                     /locus_tag="KNP36_002189"
     CDS             7656..8714
                     /locus_tag="KNP36_002189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012101107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBF0874058.1"
                     /translation="MGNKMRASVLYNVGDVRYEMVNIPEITDTQVLVNVKYVGICGSD
                     LPRSMVSGLSGNTKYPLILGHEFSGEVVKIGEKVKHINVGDRVAVAPLVPCGKCDYCN
                     EGNFGLCDDYNIIGTRVNGAFAEYVRVPEEHILKLPDTLDYETAAGIEPATIAYHGIS
                     KSNIRVGDSVVVLGCGPIGQFVIQWAKVFGASKIIAVDIFDEKLELSKLLGANYILNS
                     KEVNVIKEIKKITNGGADVVIETAGSRFTQEQSLFVAKKRGNIVFVGISHTELPLSAD
                     ATECILRGELTLKGSWNSYTSPYPGRAWTATLDFMEKGDIIFKPMISDKIGLNEVGDF
                     LSKMSKREINFNKILVEI"
     gene            8813..9499
                     /gene="araD"
                     /locus_tag="KNP36_002190"
     CDS             8813..9499
                     /gene="araD"
                     /locus_tag="KNP36_002190"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HBF0874059.1"
                     /translation="MLENLKEEVLKANLELPKKKLITYTWGNVSGIDREKGLVVIKPS
                     GVEYSNMTVEDMVVVDLEGNIVDGKLRPSSDTPTHLVLYKEFEELGGIVHTHSSWATI
                     WAQIGKSIPSCGTTHADYFYGSIPCTRKMTREEICNEYEKETGNVIIEEFMGRNPIHC
                     PGIIVNDHGPFTWGKDANEAVHNAVVLEEVAKMAYYTELMSPDNIMDKVLMNKHFSRK
                     HGKNAYYGQK"
     gene            9517..10164
                     /locus_tag="KNP36_002191"
     CDS             9517..10164
                     /locus_tag="KNP36_002191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HBF0874060.1"
                     /translation="MLDSLKGKVVEIAIKAEHYGLCKEKTGNFSIRDKDTGYILITPS
                     GVGREELKVEHICVLDLDGNVIEVEKGIKPSSEVLMHIEIYKTRENINAISHTHSLYA
                     TAFSVAKKPIIPIVYESVNYGGYVDIASYERPGTLKLAKSVSKLLIDTDACLLERHGL
                     TTVGNDLDEALLKSRYVEEVAEIYYRSLVLNQFKELEVVDVDEFKSWKYPEEIKF"
     gene            complement(10337..11704)
                     /locus_tag="KNP36_002192"
     CDS             complement(10337..11704)
                     /locus_tag="KNP36_002192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HBF0874061.1"
                     /translation="MNLIDILNKVDAFIWGPPLLVLLVGTGILLTVKLGVVQITKLPR
                     ALKLIFSAENKGSGDVSSFAALCTALAATVGTGNIVGVATAIKAGGPGALFWMWIAAF
                     FGMATKYSEGVLAIKYRTKDKNGQVSGGPMYYIVNGMGEKWRPLAIFFAISGILVALL
                     GIGTFTQVNSITDAINNSFGIDPRITGVVLAVFVALVVFGGLKSISNVATKIVPFMAV
                     IYVVICGIILISFWNKIPETFMLIIKSAFTPTAATGGFLGATMSLAIRNGIARGVFSN
                     ESGLGSAPIAAAAAKTEWPAEQGLISMTGTFIDTIIICTLTGFSLVISGVWCSDLNGA
                     VMTQAAFNGAIPTFGPILLTVSLTLFAFTTILGWSYYGERCFEFLFGVKGMNGYRTVF
                     VAMVLLGAFLKLEVVWIIADIVNGLMAIPNLIALLALSPIIVSETKKYFEHINSPENQ
                     IKKNA"
     regulatory      complement(11894..11982)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            12410..14530
                     /locus_tag="KNP36_002193"
     CDS             12410..14530
                     /locus_tag="KNP36_002193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase III"
                     /protein_id="HBF0874062.1"
                     /translation="MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGH
                     LVTLADPESYGERYKSWSLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVI
                     ATDAGREGELVARWIIEKSQVKKPIKRLWISSSTDKAIKDGFAKLRSGKEYENLYYSA
                     IARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLE
                     LIATKGNSDIKFIWNDKNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPAL
                     YDLTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIK
                     AVNISDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYN
                     LVVKRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESI
                     PNVLEKDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSF
                     LMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMKD
                     YSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTIS
                     QVTNSRCPNCHKKLELRGEGEGRLFTCSCGYREKLSSFNKRKQEEKQKASKKDVNQYL
                     KNQNKNQETFNNPFAEALAKLKNK"
     gene            14634..15887
                     /locus_tag="KNP36_002194"
     CDS             14634..15887
                     /locus_tag="KNP36_002194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flagellar protein FliS"
                     /protein_id="HBF0874063.1"
                     /translation="MDLSGIFKYYCKECENTWNNSSVELFENIETYSKDSQKKREKEL
                     DKLLNTISVHLERYPSDAVLRKMWVKKGEVFLQKTLEKENIFKLEKMDVEDRKKFLDI
                     TKQFIRDARKFDDDLPIGDIMQAMRNVWISNALQLLFGKEVYYSKANFAYSMLYPYTD
                     NYLDNTNIDKNDKILFNNWLEKRLLGEHIKSKDYHESKVSQMIDYIESVYPREKFTEV
                     YESLLLIFKSQVNSLKQHGKENHLCKEDLLSISIEKGGSSVLVDGYLISGLMTKEEIE
                     FCIGYGFLLQISDDLQDIKEDLKYNHKTIITEMSKEGTLDKVVNKLINFTIELIDSFK
                     INNKNKSVIAMIKNDCLMLILFSVVYNAEFFSVGYIKEVEKFIPYTIDYSLEIEEKIK
                     EKFKNIDVLNNENEYKEMIDIICAE"
     gene            complement(16041..17102)
                     /gene="ytvI"
                     /locus_tag="KNP36_002195"
     CDS             complement(16041..17102)
                     /gene="ytvI"
                     /locus_tag="KNP36_002195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBF0874064.1"
                     /translation="MDIQKQKNFIIKFTYVVLITSIVYIVLKFLLPLLMPFVISFIIA
                     SILRPIIRLITNNTNLNRTLISIVILLIFYGLCIFLLVSFGVKIFASVSDVFFRLPEI
                     YKSSIQPTLNTLFSKIDASTPNVNLALILGWDNISQSMMSLVASISTNALNAIASIAS
                     KTPAFMLKLIITLIASFFFTFDYQKIVNFILKQFPEKSQFMIINIKNSSINALLKLLK
                     AYAILLSVTFIELLIGLTILKVENAFTISVIIALVDILPVLGTGSILTPWMIISLING
                     NINLAIGLLILYIIITVVRQILEPKVVGHQIGLYPLITLMCMFVGAQLFGIAGLFGFP
                     IAATIIKNLHDNGIITAFK"
     gene            17376..18116
                     /locus_tag="KNP36_002196"
     CDS             17376..18116
                     /locus_tag="KNP36_002196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase"
                     /protein_id="HBF0874065.1"
                     /translation="MKNFRDLGGNKTEDGRTVKKGLFYRSAKLSNLSENDIKILKELN
                     IKYIFDYRSDEEARKHPSTIISNIKNIRIPAMRELEESGGSFGSIEDMIDGLFEKDGA
                     FNMLNNSYYNLPINNPSYKKLVELIRDYSNLPILNHCTAGKDRTGVGSAIILMILGVS
                     RENIMKDYLKSNDFADKEIERFIEYKPKFKDIPKENLKYIFGVNEEYMKTAFRRIDEE
                     YISVEAYLYGEFNLNKEEIRKLRNQYLE"
     gene            18128..19906
                     /locus_tag="KNP36_002197"
     CDS             18128..19906
                     /locus_tag="KNP36_002197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0874066.1"
                     /translation="MSLNITARQINIIKILLNSKDTISGIALSQEIGCSSKTIQNEIK
                     DINKQLRNGKILSIRGVGYKLEGSFDEVNLNSNLYDDVDRVEYIIRKILTLSNEEKNT
                     IKLEDLADSMYVSVSTVKNDLKEVKRMLEKYSISVKSKHKQGICVLESEDKILNCIVD
                     LSNKRDNQLSLNDFLNDDIKERKLLIKKLLLDILNENGLVLTDIEFKSVLNNILVMLS
                     RHKYNEKEFIENYIENYRSKRSSILENEQNKEIIINSIKTFCKNLKLATSIDISNDKV
                     FEEFLYKHISSLCKKIKLGINQSPIMAQDIKIKYPFAFELANIAKKTIEKDLKIEINE
                     DEVANIALHIGGAVERASYNNKDKVFKTIIVCTSGIGTSMLIKAKLENIFKEKLEILK
                     IIPSYLVEYIKVIDVDFVISTVPIEVGDVPVINISPILSEKEIRLIEKYIETGNIYLD
                     LDIKSLFDSELFFTDLVFKRKEEVIDFMASKLVQKGYIDEDMKKSYFEREKIATTEIG
                     NMVTIPHGAIGKIFDNKIAIGILKKPISWEISDVRLIIMLALDKDKILDYEVIFSKIY
                     KRVDSIAKVISICENSSFEKFVNLFN"
     gene            20073..20990
                     /gene="pfkB"
                     /locus_tag="KNP36_002198"
     CDS             20073..20990
                     /gene="pfkB"
                     /locus_tag="KNP36_002198"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HBF0874067.1"
                     /translation="MIYTVTLNPSIDYIVKLDELKTGSTNRVKEEYVYPGGKGINVSR
                     IFKELGNDNTSLGFISGFTGEYIIRTLEEKELKTDFIKIKSGFSRINVKIKALKETEI
                     NGQGPNIDDEDIDTLYKKLDKLNQDDILILAGSIPSTLDEKLYENIMARLEKKNIKVV
                     VDATKNLLLNVLKYKPFLIKPNNDELEELFGVKLNSIEDMVKYARRLKEMGAINVLVS
                     MGKDGALLITEEDEVLISDVPKGKVKNSVGAGDSMVAGFISGYLNTGKYDYALKLGAA
                     SGSATAFSYDLAKREYIDKLVNEISVKQF"
     gene            21027..22946
                     /locus_tag="KNP36_002199"
     CDS             21027..22946
                     /locus_tag="KNP36_002199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0874068.1"
                     /translation="MKIIDLLDEKSIKLNLNSKTKSEAIEELVDLVANSGNLNDKENY
                     KKAILAREEMSTTGIGEGVAIPHAKNSSVTKACIAAAVSKEGIDYESFDGSLSNLFFM
                     IAAPDGANNTHLEVLSRLSTILMDEDFRNKLINSSSEKEFKEIIDKKEREKFSEEYQD
                     EKVTEKNIIDTKENDANKYPKVLAVTACPTGIAHTFMAAESLNKMAENKGVSIKVETN
                     GSAGVKNKLTKDEIENATCIIVAADKNVEMARFNGKKVIKTKVADGIHKAEELIDKAV
                     NGDAPIYHGGDGSHNESNEESESGFRKVYKHLMNGVSNMLPFVIGGGILIAIAFLLDD
                     YTINPSNFGSNTPIAAFFKGIGDKAFGFMLPVLAGYIAYSISDRPAFVVGFVGGALAG
                     DGGSGFLGALLAGFIAGYLVEGLKKIFSVLPASLEGIKPVLLYPLLGTLLMGIIMTFL
                     VIPPVTAINNAMVGFLNGLGGTSKIVLGLVLGGMMAVDMGGPVNKAAYVFGVASLESG
                     QFEIMAAVMAGGMVPPLAIALATTFFKNRFTKEERDSGKVNYVMGLSFVTEGAIPFAA
                     GDPLHVIPACVGGSAVAGALSMLFNAALRAPHGGVFVIPVVTHPFAYILAIAVGALVG
                     MMLLALLKKPLNQEV"
     gene            23542..25068
                     /locus_tag="KNP36_002200"
     CDS             23542..25068
                     /locus_tag="KNP36_002200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBF0874069.1"
                     /translation="MNESYWFLNSSPKEYNKLGENIKTDCLIVGGGITGLTTAYLLAK
                     EGKKVVLVEADKIGYGTSGRNTGKVTCQHDIFYSKIEKKYGLDKAKSYYNANNEALNL
                     VEQIIEENNIKCDFKRETSFVFTEKEDTIKDIKDEYRTCKKIGINCEYHETIENIPLD
                     IKGAISFTNQGQFNPKKYIDGLAKAAVNLGLKIYENTPVVDLEKGKICRVKTREDNII
                     EAENVIISSHSPWYDGLNFYFAKEYAERAYLMVAVLENKLADGMFISIDDPSITFRQY
                     NDGSENLLIFGGGDHKVGQGGTEKEIFDDLEHYGKEVFKVKDFKGKWSAQDNMSFDNV
                     PYIGYINKREDNIYVATGFSKWGITNGTAAGIIIKDLIINNNSDYKDTFNPSRLGSYF
                     SKDFIKENANVAINYVSGKLKIGSGDMPKNNGEGKIVNIDGKRYGVYKDDNGDFYIVD
                     TTCTHLGCELNFNSEEKTWDCPCHGSRFDYKGNILEGPALKPLKLYGHGDNDVNPKLL
                     "
     gene            25096..>25632
                     /locus_tag="KNP36_002201"
     CDS             25096..>25632
                     /locus_tag="KNP36_002201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874070.1"
                     /translation="MNKLLKPITILLYIVYILSAVFFVANKEYGSLGLVAISLVGTFI
                     LSFINKQTERLLSKELYIMLALFIMFSSLLGTCFNFYDINYYDDFLHLWSGIISCIVA
                     FSIIKYFYTQREISKMSKVFLVIFLFMFSMGVASLWEIGEFLMDTFVGTTTQAGGLED
                     TMIDMVDALIGTIITIPFI"
BASE COUNT        10189 a         2714 c         4376 g         8353 t
ORIGIN      
        1 aattaaactt aaaagtatat ttgcttatct ttttagtaaa taaaatgaaa aaaagaatta
       61 gtggacttat gtaaatatta aatttaataa cttctataaa taattccata aaatacgtct
      121 cctattttct tttttttagc cattgttcaa gttcttttat gtcatcatct gatatttcat
      181 ttccacaacc taatgatgat ataaagctat gaatagaatt tttatgtata agctctaaaa
      241 aatcctttgt ttcaaatttt agatattcct catgtttaac tttaatagtg tataaagtat
      301 ttctaccatc tttttcaaat tctaaaaaac ctttatcact taatctagaa agtactttac
      361 cagtagtacc ttttgtccat ccatgagaaa tttccatata attagctact tctctggctg
      421 gtattttatc tatgtcttta tcccatatga aattcataac taacaactcg gattttggta
      481 tttttttcaa tataatcact cacctttaac ttgattatat tagacaaatg tctaatagtc
      541 aatataatat atcatcatgt ataaataatc tttatattat tttatgcttg agaactaagt
      601 agtatagatt tatagataaa aaagatattg agagttttat ggaagagggg aatatatttt
      661 ctattagaga taagaatatg acatatattt tttattgatt tttacaaaaa tactatatag
      721 tgaataaatt aatatctttt ctaaattaga agaggagaat cttattagat aaagattatc
      781 ctctttattg aaagtttaag ggatattaga gattattaat ttttctctct ttttttaact
      841 aaaagcaata atacataaaa ttattattgc taatgatact cttaatgtgg tatatagtca
      901 tagtgtcaca tgtttatcaa tagttttttc attaattatt gtaacgaata gtaggactca
      961 taaaatactt agaaatatgt ttttagatag attttaaata tataatctaa cttatatcta
     1021 taaattaaca ctattattct ccaattccat ttctagtttt tttataaatt tattaaattc
     1081 ttctggttgc ctttttccaa acaatactct tacaagagct gaattgattt ttccaaatat
     1141 attcctcttg ctctcacttt caataaaaat aagttttgta ttttctaagt caatatgtac
     1201 taattcatat ctagtaatag tactttctct tttattgctt gtttttatct catatactct
     1261 atttttttcg aaattagtta tttcaacctt aaatctttta ttattttttt gctgtacaaa
     1321 tgttcctact gcttttttct cattaaaatt aggaaaattt agtcttgcag attttgtaaa
     1381 tatattaaat atgtcttttg cagaatattt taataaaact tcagttttaa atgtattcat
     1441 atcgttttcc cttctgtata taaatttaat atttataagt taatttttaa gttaaaatag
     1501 tataatatgc catattaaat catgttaaaa ctatttatat agctaaaatc ttacctatat
     1561 aagtatgtat actatcatat aaaaataaaa tcttaaaata gaaagggtta aaaacacagt
     1621 ttattataat ttttattgtt gagtagatac gtactattat atatgattga gcaagttttt
     1681 caatcataaa tttataaagt attttgcatt aaaatttaaa caaagaatta aattatttaa
     1741 gattatgaat aactaataca tttagtaaat tactaaatat acaaaatgta aatacttatc
     1801 aaaatgtata aatacttatg acatctagtt acttacaggg tttaagtaga aaaaaatatc
     1861 aaagtaagta tggcatgata gttgcttata tatttatcaa gaaaggagtt attaagcatg
     1921 gagttgagag ataaacttgt aaacatcata aatacagaaa ataaaaaaga tccattaaca
     1981 gatgttcaaa tagcaaagtt tttaagtaca actagagaga acataactaa tttgagaaaa
     2041 gaacttaata taagtaattc aaggcaaaga agatatcctt atttaaaatc agcaatttcg
     2101 gcaatattac aaaagaataa gaatatttct atatcagaaa ttacaaggga attgatgaca
     2161 gaaggcttta atatatcgag aagagttgtg gaggaacttt tacctaaaga aagtttagaa
     2221 atggatgtag tagaggaaga tgaagaagaa tcgaatgacc catttgaaac tctgataggt
     2281 aataaaggga gtcttagaaa tgctgtagag caggctaaat ctgctatatt gtatccacca
     2341 aaagggttac caacgttgat tattggggaa agtggagttg gtaagagttt attttctaga
     2401 catatgtatg agtttgcaaa gcaaaaaaag atagtaaaag agagctccaa ttttgttgta
     2461 tttaactgtg ctgattatag tgacaatcca caattattat tatctttgtt atttggatat
     2521 aaaaaaggtg catttacagg tgctgaatat gatacaccag gtcttgtaga agaagctgat
     2581 gaaggagttt tatttttgga tgaaatacat agattgcctc caaaaggtca agaaatacta
     2641 ttttctatct tagatagggg aaagtttagg agattaggtg aaactaatgc tgaaagaaaa
     2701 gtaagtatta tgttgattgg ggcaactact gaaaatgtag agactaattt attattaaca
     2761 ttcagaagaa ggataccaat gctaataact ttgccaccat tacatgatag attactaaaa
     2821 gagaaaatag accttatata caatatcttt caacaagagt gtaatagaat aaatgcaaaa
     2881 atatttgtag ataaaaatgt gattgaaata cttgcactaa aaaagtttag tggaaatata
     2941 ggacaattac aaaatatgat tcaggttctt tgtgcaagag cttttatgaa gtttataaat
     3001 tccaaagatg aagatagtga atctatagta gtagtagata taaatgaagt tttaaagctt
     3061 aaagattcgt ttaaagatgc tgcctttcaa gagattgaat atacagagat aagaaaatat
     3121 ttgaaaaatg ctatatttat accatttaat ttagaagaat catcagtaaa aggaagtctt
     3181 ttaagtgatg aatatatatt accagaggac atatacaaaa caattgaaaa gaaatattat
     3241 gacctaaaat ccctagacat tgaagatata gatatagaga atattttatg gacttttatt
     3301 ttaaatagat ttgctgactt aaagtttaat cttgatagta atgaagaaat tttttcaatg
     3361 agtgatttaa atagttttgt aagtgatagt ttagttaaac tggtaaaaga acttatgaat
     3421 gatatagttg aaaaaaatat gaatttagaa gtaaataaaa atatgttcaa atatctagca
     3481 atacacttag aagaagctat aaaaagaatt aagctaaatc aaaagataat aaatgtaaat
     3541 ttagaaaaaa taaagattga cttttcaaaa gaatatgaaa ttagtaaaag ttttgcaata
     3601 aaaattgagg aatcaattgg tattaagatt tcagatgatg aaattggatt tataacgctc
     3661 tacataaagt ctgctctaaa aaatgaagtg aaaaaagata aagtagggtt aataataatt
     3721 tctcatggac gtatagctac agagactgta aatgtagtta aagaactttt aggtgtaaag
     3781 tttcctgtgg ctatagatat gcctttagat gaaaaaccaa taaatatata caataaggca
     3841 gtagaattgt caaaaataat agaccaaggg aaaggcatat tgtttttggt ggatattggt
     3901 tcacttacaa acataggtca aatagtaaat aagagaacca atataagtac taaaactatt
     3961 gatagagtag acctcctaat ggcactagaa gcaactagaa aagtttctat gggagaggaa
     4021 gaacttgatg aaatattttt ttctttgcta aaagatagga tgggatataa ctatgaatta
     4081 gaaaaacaca tagataaatc aaatgcaatt ataacattat gtcttactgg agaaggaact
     4141 gctaagtata taagtaaaac gttggaagaa aagtatgata acactaaatg ttatcaaatg
     4201 agtgcattgg atgaaagttt attttgtaaa attgaaaatc taaaagagac aaacaatata
     4261 ttagctattg ttgggacaat aaaccctaag ataccaggta taaattttat accctataat
     4321 aaagaacttt tcaaaaattt ggatatctat ctatcaaaat caaaacaaca agatgacaga
     4381 ccaattaaat cgtatgaaag aatgcttgat gaggatttag tgatttttga accagatata
     4441 tattttaaaa aggatttatt agaatatgta tgttcaattc ttataaataa agaatatgta
     4501 gaaaaagatt acttagattc tgttttacat agagaagaaa tgcttccaac atattctaaa
     4561 ggagctatag gtgtgcctca tggagattct tctactgtaa atagtacaag gtttgttttt
     4621 gttaaactaa agaatcctat tgattggggt gtaggtaatg taaatttcat atttatgcca
     4681 gtttttcagg ctaatgataa agagattgtt aaaaatgttc ttgagatact aaaagatgca
     4741 gaatttatga acaatgccaa taagtgtttt gataaagatg cttttagaag gattatattt
     4801 gataaattta aacatctgta gccatagcaa aaaaattgag aggagttaga gtaatgaatg
     4861 tagatttaat atcattgggt ttagaatcta atgattatga aagtgttatt gaagaattag
     4921 gaagtataat gtgtaaaaaa gaatatgtaa aagaaacata cataaatgct gtcttggaaa
     4981 gagaaaggac attaccaaca ggtctagata ttggagacat gtgtgttgct attccacata
     5041 cagattcaaa gcatgtaaat gagtctaatg tagctgtagg gatattgaaa aatcctgtaa
     5101 agtttaattc aatgatagac ccaaaagata gacttgatgt agaacttgta tttttattag
     5161 cagtaaagaa cccagactca caagtaaaac tgttaaaaga tttaatgtca gtttttcaaa
     5221 atataaagtt attaaaaaat ataaaaaacg catcaacaaa agaagaagta gctaaattat
     5281 tggattttat agaaatttaa tgtaggagaa ttttataaat aaaaaattaa aatttaaaca
     5341 atcaaagtaa gtattatttt tttaataggt ttaatcttat ataaaataaa aatttagagt
     5401 gaaaaattag gaggaaatta ttatgaaaca atttaatgta ttatcagttt gtggttcagg
     5461 gacagttaca tcatctatgg tagcaggtaa attaaaagaa gtactaggta ataaggggat
     5521 ttctattact acaacagaag ctagaccaac agaagcacta aatttagcac aatcaggaag
     5581 atttgacttt ataacattta cgagtccact tcaaacaggc gattatggaa taccaactat
     5641 aaatgcattt gcttgcctaa ctggtatagg ggaagaggca ttctttgaag aagttttgac
     5701 tgttattgaa gggatagata agtaagtttt ggagacgtga atttatagta tttaaatcaa
     5761 tgatttagat actataataa gctaatatta actaaatatt tgtggaaaaa acattttata
     5821 tgttgtcata aattaaaaaa ttataaaaat agtcacttaa gtattaaatt aagcttataa
     5881 atatttataa gtaggaggga aaaagatgtt agaatttatg aaatctataa tcgatacatt
     5941 tggttctgca attatagttc caattataat attcataatc gcaaagatat ttaaagtaac
     6001 tactaagaaa tcgtttcttt ctgctgtgta tgcaggagtt gctttacaag gttttacact
     6061 gattttaaat tcatttacac cagtaataac accagttatc aataggatgg ttgagagtac
     6121 aggagtaaac ctaccagttt ttgatgttgg ttggcaagca acatcattgg ttgcattttc
     6181 aacaagtgca ggtatgatat atttaggtct tggtatatta ttacaaacaa ttttattttt
     6241 gataaaatgg acagatgtgt ttcaaccatc agatttatgg aataactatt cttatatggt
     6301 atggggagca atggttatag gagtaacagg aaattttcct ttaggtatag catgtatggt
     6361 tttattaaac ctatatagtt tattaatatc agagttagtt gcaaagagat ggtctagtta
     6421 ctatagatat cctaattgta caataatagc tatgcataat gttgaggctt ctgtgtttgc
     6481 agtatttgca gaccctatat acaataaatt gggattaaat aaaataaaat taaatccaaa
     6541 agaattagag aagaaattag ggtttttagg tgaaccaatt actttaggtc tttttttagg
     6601 tatgtttata ggtatattag gtaatatgac gagaataaat actatggaag cttggggaga
     6661 aataatgaaa gtaggtatat ctacaagtgc agtgatggca attttcccta aagtagcaag
     6721 tatgtttgct caagcatttg cacctataac agaagcagct agaaagatta tgcaaaaagc
     6781 tggaaaccgt gagtggtaca tagcagtaaa tgatgctgtt ggatatggtg aacctgcaac
     6841 tttaatatca ggtcttatat taattccaat aatgcttgta atagctatgg tacttcctgg
     6901 taataaggta ttaccagttg tggatttatt ggcaattcca tatatggttc aaggtttagt
     6961 tgccatacat aatggtaata taccaaaagt attagtttca ggtataattt ggtttggatt
     7021 aggattatat gtttgtacat ctacagcacc attatttaca gatatggcta caaatatagg
     7081 tgtagctata cctgcaggag caatgttaat aacaagtttt aatatactag gaaaaccttt
     7141 gatgggatta gttttctttg catttctaag tgcaaatcca atttatatag gtctttcagt
     7201 tgtaatttac tttgttctat gggcattgtt tagaaagaac aaaacaagta ttcttgatta
     7261 tttagaaaaa caagcactta aaaatgtaga agaagagcct gtagcagttt aagtttataa
     7321 aaatgaaata aaaataatta aaggagttta taattgattt tatataagta tcagataata
     7381 cctgagaaat atttaaatga aatatagact tctttttatt tgataatatt tgtaattata
     7441 atgcattgta tttttatagt tgagttttct gtataacctg ctatttaaaa catactcttt
     7501 tatatttata cagtaatgtg gtttaatttt ataaaatgta atctctactg gtaaaagact
     7561 ttgtatataa ggcatttgcc tgaataaacc atttatcttt tgtatggcat agatattgct
     7621 atatagaagt atatagcatg aaaggagata tttatatggg aaataaaatg agagcatcag
     7681 tattgtataa tgtaggtgat gtcagatatg aaatggtaaa tataccagaa ataacagata
     7741 cgcaagtgct tgtaaatgta aaatatgttg ggatatgtgg ttcagattta cctaggtcta
     7801 tggtaagtgg tttgagtgga aatacaaaat atccattgat tttagggcat gaattttctg
     7861 gtgaagttgt taaaattgga gaaaaagtaa agcatattaa tgtaggagat agagtagctg
     7921 ttgcaccatt agtaccttgt ggaaaatgtg attattgtaa tgaaggtaat tttggcttgt
     7981 gtgatgatta caatataatt ggaacaagag taaatggagc gtttgcagaa tatgtaagag
     8041 ttccagaaga acatatttta aaactaccag atacattgga ttatgaaact gctgccggaa
     8101 ttgaaccagc aactatagct tatcatggga tttcaaagtc taatattaga gtaggagata
     8161 gtgtagttgt gttaggatgt ggtccaatag gtcagtttgt tatacaatgg gcaaaggtgt
     8221 ttggtgcatc taagattata gcagttgata tttttgatga aaaattagaa ctttctaaac
     8281 ttctaggagc aaactatata cttaactcaa aagaagtaaa tgtaatcaaa gaaataaaaa
     8341 aaataacaaa tggtggtgct gatgttgtaa tagaaactgc tggtagccga tttacacaag
     8401 aacaatctct atttgtagca aaaaagagag gaaatatagt gtttgtaggt atatcacaca
     8461 cagaattacc acttagtgca gacgctactg agtgtatatt acgtggagaa cttaccttga
     8521 aaggttcttg gaattcatat acaagccctt atcctggaag agcatggact gcaacattgg
     8581 attttatgga aaaaggtgac attattttta aacccatgat ttcagataaa ataggtctta
     8641 atgaagtggg tgacttttta agtaaaatga gcaagagaga aattaatttc aataaaatcc
     8701 tagtagaaat ataaaaattt aataaaaaat tctaaaagca attaaatttt ataactatga
     8761 cattaaataa aataaaaata attttcttaa ataaaatata ggaggaagaa aagtgttaga
     8821 aaatttaaaa gaagaagtat taaaagcaaa cttagaatta cctaagaaaa agctaattac
     8881 ttatacttgg ggaaatgtaa gtgggataga tagagaaaaa ggattagtgg tgataaagcc
     8941 aagtggtgta gagtatagta atatgactgt agaagatatg gttgtagttg atttagaggg
     9001 aaatatagtt gatggcaaat taagaccttc ttcagatacc ccgactcatc tagttttata
     9061 taaagagttt gaagaattgg ggggaatagt acatacacat tcaagttggg caacaatttg
     9121 ggctcaaata ggaaaatcta taccatcttg tggtactact catgcagatt atttttatgg
     9181 aagtatacca tgtaccagaa aaatgactag agaagaaatt tgcaatgaat acgaaaagga
     9241 aactggaaat gtaatcattg aagaatttat gggaagaaat ccaattcatt gtccaggaat
     9301 aattgtaaat gaccacggac cttttacatg gggaaaagat gcaaatgagg ctgtacacaa
     9361 tgcagtagtt ttagaagaag tcgcaaagat ggcttattat acagagttaa tgagtcctga
     9421 taatattatg gataaggttc ttatgaataa gcatttttca agaaaacatg gaaaaaatgc
     9481 atactatggt caaaaatgat tatctggagg tgaattatgc tagactcttt aaaaggtaaa
     9541 gttgtggaaa tagcaattaa agcagagcat tatggtttat gtaaagaaaa gactggtaat
     9601 tttagtatta gagataagga tactggatat atacttataa ccccatcagg tgtaggaaga
     9661 gaagaattaa aagttgaaca tatttgtgta ttggatttgg atggaaatgt aatagaagtt
     9721 gagaaaggta ttaagccaag tagtgaggta ttgatgcata ttgaaatata caaaacaaga
     9781 gaaaatataa atgccatatc acatactcat tctttatatg caacagcatt ttcagtagca
     9841 aagaaaccaa ttataccaat tgtatatgaa tcagttaatt atggcggtta tgtagatatt
     9901 gcttcatacg aaagaccagg aactttaaaa ttagctaaga gtgtttcaaa attactgata
     9961 gatacagatg catgcttatt agaaagacat gggttgacaa ctgtaggtaa tgatttagac
    10021 gaagcattat taaaatcaag atatgtggaa gaggtagcag aaatatacta taggtcttta
    10081 gtattaaatc aatttaaaga acttgaagta gtagatgttg atgagtttaa atcttggaaa
    10141 tacccagaag aaataaagtt ttaatctaaa taattttcat tgaagtggtt aattaaaata
    10201 tatgtattat ttatatcaat tactatgttt tattatgtta attaccgtat tttgcaaata
    10261 tatttattac attttttcaa aaaaatatag aatccgaaag ccatataaaa ttgacttggg
    10321 attctatact ttttatttat gcatttttct ttatctgatt ttctggagaa tttatatgtt
    10381 caaaatattt tttagtttca gatactatta taggtgataa tgcaagtaaa gctataaggt
    10441 taggtattgc cataagccca tttacaatat cagcaattat ccaaacaact tctaacttta
    10501 agaaagcacc taataacacc atagccacaa atacagttct atacccattc atgcctttta
    10561 caccaaacag aaattcaaaa catctttctc cataataact ccatcccaaa attgtagtaa
    10621 atgcaaataa tgttaaacta actgtaagta atattggtcc aaatgtagga attgctccgt
    10681 taaaagctgc ttgtgtcata acagctccat ttaggtctga acaccacact cctgaaataa
    10741 caagagagaa tccagtaaga gtacagatta taatagtatc tataaaagta cctgtcatag
    10801 atataagacc ttgttccgct ggccattcag ttttagcagc agctgcagct attggagcac
    10861 tacctagacc agactcattt gaaaatacac cacgagcgat accatttcta attgccagtg
    10921 acatagttgc tcctaaaaaa ccaccagtag cagcagtagg tgtaaatgca cttttaatta
    10981 ttaacataaa agtttcaggg attttattcc aaaaagatat taaaatgatt ccacagatta
    11041 caacatatat aactgccata aaaggtacta ttttagtagc tacattagat atacttttaa
    11101 gtcctccaaa tacaactaaa gctacaaata ctgctaatac aacccctgta attctagggt
    11161 ctatcccgaa actattattt attgcatctg ttattgaatt tacttgagta aaagtaccga
    11221 ttcctaaaag tgcaactagt ataccactta tagcgaaaaa tattgcaaga ggtctccatt
    11281 tttctcccat accatttact atgtaataca ttggcccacc agacacttga ccatttttat
    11341 ctttagttct gtattttatt gcaagaacac cttctgaata cttagtagcc attccaaaga
    11401 atgctgctat ccacatccaa aaaagtgcac caggtccacc agctttgata gctgtagcaa
    11461 caccaacaat attaccagta ccaactgtag cagctagagc agtacataag gctgcaaaac
    11521 ttgaaacatc accactacct ttgttttcag cagagaatat taacttaaga gctcttggca
    11581 gtttagttat ttgaacaact ccaagcttaa cagtaagtag tataccagta ccaactaata
    11641 gtaccagtag gggtggtccc caaataaaag catcaacttt gtttaaaata tcaattagat
    11701 tcataaaaac actccctcat tttttttgct ttacataatc aatagaattt ttaatgaagt
    11761 aattgacagg aaataagtat aatttattaa taatttctag tgtaataaaa aaagctaaat
    11821 ctaaaaaaga ttcagctctg gatgtacact aattagcaac caaaataaaa gtattagtaa
    11881 atactgtttt tggtagataa tccctgtcct tttgcctgag agattgagca taaaagcctt
    11941 gccccttcgg cgcccataat gggtctctcc agagttccgt aaattttaca gtcctacttt
    12001 taaaagtacc tgagagtgtt actccttcgg tgtgctatat agcaactctt ctataaaatc
    12061 ttaaccggat attgatttgt catagcttat tgtattaata atattaatat aagtttttat
    12121 gttttgtcaa ctaaaaaatt aaaaaacaaa gaaaaaatat aaaaatgtaa gcctatttac
    12181 gaattataaa cttagaaaga tgagtaatat acgtgaaaat gaattttgta atacacatac
    12241 aaatgaagtg taaaataagt tttaaataaa aaaataataa aatcttaaat aattaattag
    12301 atatgattaa attatggtaa tattatagtt acgatattaa gaaaagttct atttagttag
    12361 attttaagcg taatatgaga ttatgtatag agaaaggatg tatttttaga tgggaaaaat
    12421 attagtgcta gcagaaaaac cttctgttgg aagagatata gcaaaagttt tagggtcaaa
    12481 aaatgaaaaa aatggttata tagaggggcc aaagtatgtg ataacttggg cactaggtca
    12541 tttggttaca cttgctgacc ccgaaagtta tggagaaaga tataaatcat ggagcttaga
    12601 agacctgcca atacttccca agcaccttaa gactgttgta ataaaaaaga gtggaaagca
    12661 gtttaataca gttaaatcgc aaatgaatag aaatgatata gatgaaatag ttatagcaac
    12721 agatgcaggt cgtgaaggag aacttgtagc aaggtggata atagaaaaat cacaggtaaa
    12781 aaaacctata aaacgtcttt ggatttcttc aagtacagac aaagcaataa aagacggatt
    12841 tgcaaaatta agaagtggaa aagaatatga aaatttgtat tactcagcaa tagcacgagc
    12901 agaagctgat tggattattg gaataaatgc aaccagagct ttgacaacaa agtacaatgc
    12961 acagctttct tgtggaagag tacaaactcc tactcttgca atgttgctta aaagagaaga
    13021 agaaataaga aatttcaaac ctaaagagta ttatggatta gaattaattg ctacaaaggg
    13081 aaattcagat ataaaattta tttggaatga taaaaacaat aattcttcaa cttttagtaa
    13141 agaaaagata gaatccacat taaaaaaagt aaaaggtgta gacataaaaa tatctgaagt
    13201 aaacaagtca tataagaaaa aatattcacc tgcactctat gatttaacag aattacaaag
    13261 agatgcaaat aaaatgtttg gattttcagc aaaagaaact ttatctataa tgcaaaaact
    13321 gtatgaacat cataaagtac ttacttatcc tagaactgat tctagatatt taacatcaga
    13381 tattgttgga acattaaaag atagaataaa agctgtaaat attagtgatt attcaaagat
    13441 ttgtaataga ttattaaaaa gcaatattat agctaataaa tcgtttgttg acaattcaaa
    13501 ggtaacagac caccatgcaa taataccaac agaacagaag gtattcatga gtgattttag
    13561 tgataaagag cgaaaaatat ataatcttgt agtaaaaaga tttttagcag tactatctcc
    13621 tccttttgaa tatgagcaga caactataag tgcaactgta gaaggagaaa tatttaaggc
    13681 taagggaaac aaagtaataa atttaggttg gaaagaaagt tataaagata ttgaagatga
    13741 agatgagtat gaaagtatac caaatgtttt agaaaaagat gtacttaagg tcaagggatt
    13801 aaagataact tcaggaaaaa caaatccacc accatactta aatgagggaa cattattgac
    13861 tgctatggaa aagaatggtc tagggacagt tgctacaaga gcagatataa tagaaaaatt
    13921 attcaattca tttttaatgg aaaagaaaaa taaagatata tatataacat caaaaggaag
    13981 acaattatta gatttagttc cagtagactt aaagacacca gaacttacag cttcatggga
    14041 aaagaaatta ttggatattt caaagggaaa acttagtaaa aatacattca taaatgacat
    14101 gaaagattat tcaaaagata ttgtactaga agtaaaaaat agtgataata aatttaaaca
    14161 tgataactta actaaaaata gatgtccaga atgtggtaaa tttatgttag aggtaaatgg
    14221 taaaaaaggt aagatgttga tttgtgaaga tagagagtgt aatactagaa aaactatatc
    14281 acaagtaacc aattcaagat gtcctaactg ccataaaaaa ttagaacttc gtggagaagg
    14341 tgaggggaga ctcttcactt gtagttgcgg atacagagaa aagttgtctt ctttcaacaa
    14401 gagaaagcaa gaagaaaaac agaaggcatc aaaaaaagat gttaatcaat atttaaaaaa
    14461 tcaaaataaa aatcaagaga catttaataa tccatttgca gaagcattag ctaagctaaa
    14521 aaacaaataa ttttaaagtt attattatac acaattataa ctttaactgt atattagtta
    14581 tatgtactga tataatatag tgtatagttt aggcatgaaa gtagggctgt taaatggatt
    14641 taagtggcat atttaaatac tattgtaaag agtgtgaaaa tacatggaat aattcgagtg
    14701 ttgaattatt tgagaatata gaaacgtata gtaaagattc acaaaaaaag agggaaaaag
    14761 aattagataa attgctaaat acaatatcag ttcatttaga gaggtatcca agtgatgctg
    14821 tattgagaaa aatgtgggta aaaaagggcg aggttttctt acaaaagaca ttggaaaaag
    14881 aaaatatttt taagttagaa aaaatggatg tagaggatag aaaaaaattt ttagatataa
    14941 caaaacagtt tattagagat gctagaaaat ttgatgatga tttacctata ggtgatatta
    15001 tgcaagctat gaggaatgta tggatttcaa atgcattaca attattattt ggtaaagaag
    15061 tatattattc aaaagctaac tttgcatata gtatgttata tccatatact gataattatt
    15121 tagacaatac aaatatagat aaaaatgata agattttatt taataactgg ttagaaaaaa
    15181 ggctcctggg agaacacatt aaatctaagg attatcatga aagtaaagta tctcaaatga
    15241 tagattatat tgaaagtgta taccctagag aaaagtttac agaagtttat gaatcgttat
    15301 tattaatatt taaaagtcaa gtaaatagtt taaaacaaca tggtaaggaa aatcatttgt
    15361 gtaaagaaga tttattatcc atttctattg aaaaaggagg ttcatccgtt ttagtagatg
    15421 gatatttaat aagtggattg atgacaaagg aagaaataga gttttgtata ggatatggat
    15481 ttttattaca aatatctgat gatttacaag atataaaaga agatttaaaa tacaaccata
    15541 aaactattat tacagagatg tcaaaagagg gtactttaga taaagttgta aataaactaa
    15601 taaattttac tattgagtta atagatagtt ttaaaattaa taataaaaat aaatctgtaa
    15661 tagctatgat aaagaatgat tgcttaatgt taattttatt ttctgtagtt tataatgctg
    15721 aatttttttc tgtaggatat ataaaagaag tagagaaatt tattccatat acaatagatt
    15781 attcattaga gattgaagaa aaaataaaag aaaaatttaa aaatatagat gttttaaata
    15841 atgaaaatga atataaagaa atgattgata ttatttgtgc agagtagaaa aaaagggagt
    15901 gtcttagaat agacttttta gtttatgagg cactcttttt gtataaaatc aaatgtattt
    15961 tcatcatttt aacaattaaa aagagcttat ccctatttga gaaagccctt tttaatttaa
    16021 ataaaaatgt caaggttaaa ctatttaaat gcagtaataa tcccattatc atgtaagttt
    16081 tttatgattg tagctgcgat agggaatcca aataatccag ctattccaaa tagttgagct
    16141 ccaacaaaca tacacattaa tgttattaaa ggatataggc caatttggtg tcctactacc
    16201 tttggttcta atatttgtct aacaacggtt ataattatgt atagtattaa aagtcctatt
    16261 gctaaattaa tatttccatt aatgagtgag ataatcatcc aaggtgtcaa aatacttcct
    16321 gtacccaaga ctggcaaaat atcaacaagt gctatgatga cagatatagt aaatgcattt
    16381 tcaaccttta ggatagtaag tccaataagt agttctatga atgtcactga tagtagtatt
    16441 gcataggctt ttagtagttt taaaagagca ttaatactgc tattttttat atttattatc
    16501 ataaattgac ttttttctgg aaattgtttt aagataaagt ttactatttt ttgatagtca
    16561 aaagtaaaga aaaaagaagc aattaaagta ataataagtt ttaacataaa tgcaggtgtt
    16621 ttacttgcaa tactagcaat agcattgagt gcatttgttg aaatagaagc tactaaagac
    16681 atcatagatt gacttatatt atcccaacca agtattaatg ctaggttaac attaggtgta
    16741 ctagcatcta tctttgaaaa taaagtattt agcgttggtt gtatacttga tttatatatt
    16801 tcaggaagtc taaaaaatac atcacttaca cttgcaaata tcttcacacc aaagctaact
    16861 aataaaaata tacacaaccc ataaaaaatt aaaagtatta ctatagaaat aagtgtacga
    16921 tttaaatttg tattatttgt aataagtctt ataataggtc ttaagatgga tgcaatgata
    16981 aaactgatta caaaaggcat taataatggc aataagaatt ttaatacaat atatacaata
    17041 cttgttatta aaactacata tgtaaattta attataaaat tcttttgctt ttgaatatcc
    17101 ataatataaa acctccaatg tatttgatat tattctaaat atggtctttt ttacagaaaa
    17161 tatactactg tatattgatt ataaactata aagcttatgt aaagtaaata aattatgtaa
    17221 aatttaggtt aattttgtat aaagagatac ttttatattt tacaattaat aaccaaatac
    17281 taaaaaatat tttaaataaa gaacttaaaa ttgtgataaa attaatttat agatattaaa
    17341 aaaagtataa tatatggttt ttaagaggtg ctaagatgaa aaattttaga gatttaggtg
    17401 ggaacaaaac tgaggatggc agaactgtaa agaagggatt attttatagg tctgcaaaat
    17461 tatcaaatct aagtgaaaat gatataaaga ttttaaaaga gttaaatatt aaatatatat
    17521 ttgattatag aagtgatgaa gaagctcgta aacatccatc aacaataata tcaaatataa
    17581 aaaatataag aataccagca atgagagagc tagaagaatc aggaggaagt tttggttcta
    17641 ttgaagatat gattgatgga ttgtttgaaa aagatggtgc atttaatatg ttaaataata
    17701 gttactataa tttgcctata aataatccgt catataaaaa attagtagaa cttataagag
    17761 actattctaa tttaccaata ttaaatcatt gtacagctgg taaggataga actggtgtgg
    17821 ggagtgctat aattcttatg attttagggg tatcgagaga gaatataatg aaagattatc
    17881 taaaaagtaa tgattttgca gataaagaga tagaaagatt tatagaatat aagcctaaat
    17941 ttaaggacat tccaaaagaa aatttgaaat atatatttgg tgtaaatgaa gagtatatga
    18001 aaactgcatt tagaagaatt gatgaagaat acattagtgt agaagcatat ttatatggag
    18061 aatttaattt aaataaagaa gaaataagaa aattaagaaa tcaatatcta gagtaaaagg
    18121 tgagtttatg agtttaaata taacagcaag acagataaat ataataaaaa tattgttaaa
    18181 ttcaaaagat acaattagtg gtattgcctt aagtcaagag ataggatgtt cttcaaaaac
    18241 tatacaaaat gaaataaagg atattaataa acaacttaga aatggtaaaa ttttgtcaat
    18301 aagaggagtt ggttataaac tagaaggaag ttttgatgag gtaaatctaa atagcaatct
    18361 ctatgatgat gtagatagag tagaatatat aatcagaaaa atattaacct taagtaatga
    18421 agaaaaaaat actataaaac ttgaagattt agccgattct atgtatgtaa gtgtttcaac
    18481 agtaaaaaat gatttaaaag aagtaaaaag aatgttggaa aagtattcaa tatcagttaa
    18541 atctaagcat aaacaaggta tatgtgtttt ggaaagtgaa gataagatat taaattgtat
    18601 agttgactta agcaataaga gagataatca attgagttta aatgattttt taaatgatga
    18661 tataaaggaa agaaaactat taataaaaaa attattatta gacatattaa atgaaaatgg
    18721 attagtatta actgatatag aatttaagag tgtgttaaat aatatattag ttatgttaag
    18781 cagacataag tataatgaaa aagaatttat agagaattat atagaaaatt ataggagcaa
    18841 aagaagctca attttagaaa atgaacaaaa caaagaaatt ataataaatt caataaaaac
    18901 attttgtaaa aatttaaaat tagctacatc aatagatata agtaatgata aggtatttga
    18961 agagtttttg tataagcata ttagtagttt atgtaaaaaa ataaagttag gtataaatca
    19021 atcacctata atggctcaag atataaaaat aaaatatcca tttgcttttg aactagctaa
    19081 tatagctaaa aagacaatag aaaaagattt gaagatagaa attaatgaag atgaagttgc
    19141 aaacatagct ctacatatag gaggagcagt tgaaagagca tcttataata ataaagataa
    19201 ggttttcaaa actataatag tttgtacttc aggcataggc acatcaatgt taataaaagc
    19261 taaattagag aatatattta aggaaaaatt agaaatacta aagattattc cttcatactt
    19321 agttgaatat ataaaagtta tagatgttga ttttgtaata tctactgttc ctattgaagt
    19381 aggagatgtg ccagtaataa atatatctcc aattttaagt gagaaagaaa ttagattaat
    19441 tgaaaaatat atagaaacag gaaatatata cctagattta gatataaaaa gcctgtttga
    19501 tagtgaattg ttttttactg atttggtgtt taaaaggaaa gaagaagtta tagattttat
    19561 ggcaagtaaa cttgtacaaa agggctatat agatgaggat atgaaaaaat cttactttga
    19621 gagagaaaaa atagcaacaa cagaaatagg gaatatggta actataccac atggagctat
    19681 tggaaaaatt tttgataata aaatagcaat tggtatatta aagaagccta tttcttggga
    19741 aatatcagat gttcgtttaa taataatgtt agcccttgat aaagataaaa tattagatta
    19801 tgaagtaata ttttcaaaaa tatataaaag agtagattct atagcaaaag ttataagtat
    19861 atgtgaaaat agtagttttg aaaaatttgt aaatttattc aattagatgg gtagtattgt
    19921 atatacacct gtaaatttgg ataatataaa actaaataag ataaaaacga taaatttctc
    19981 ttttaattaa gagaaatttt ttgactttca aggatattaa tataaagtta agatataaac
    20041 ataaagcaaa taaataaaaa agaggtggca atatgattta tacagtgaca ttaaatccat
    20101 caatagatta tatagttaag ctagatgagc taaagacagg aagtacaaat cgtgtaaaag
    20161 aagaatacgt ttatccagga ggaaaaggta taaatgtatc tcgcatattt aaggaacttg
    20221 gaaatgataa tacatcttta ggttttataa gtggttttac tggagaatat ataataagaa
    20281 cattggaaga aaaagaattg aagacagatt ttataaagat aaaaagtggt ttttcaagaa
    20341 taaatgtaaa aataaaggcg ttaaaggaaa ctgagattaa tggacaaggt ccaaatatag
    20401 atgatgaaga cattgatact ttatataaaa aacttgataa gctaaatcaa gatgatattt
    20461 taatattggc aggaagtata ccatctactt tagatgaaaa actatacgaa aatataatgg
    20521 ctagattaga aaaaaagaat ataaaagttg tagtagatgc aactaaaaat cttcttctta
    20581 atgttttaaa atataaacct tttctaatta agcctaataa cgacgaatta gaagaactat
    20641 ttggtgttaa attaaattca attgaagaca tggtaaaata tgctagaagg ttaaaggaaa
    20701 tgggagctat aaatgtcttg gtatcaatgg gaaaagatgg agcattgttg attacagagg
    20761 aagatgaagt gcttataagt gatgttccaa aaggaaaagt aaaaaattct gtaggagcag
    20821 gtgattcaat ggtagcagga tttatatctg ggtatttgaa tactgggaaa tatgattatg
    20881 ctcttaaatt gggagcagct tcaggtagtg caactgcttt ttcatatgac ttagccaaaa
    20941 gagaatacat tgataaattg gtaaatgaga tatctgtaaa gcagttttaa aatattaaaa
    21001 aatatataga aaggtaatta atatttatga aaattataga tttattagat gaaaagtcaa
    21061 ttaagttaaa tttaaattca aaaaccaaat cagaagcaat agaagaatta gtagatttgg
    21121 tcgcaaatag tggaaattta aatgataaag aaaactacaa aaaagcaatt ttggctcgtg
    21181 aagaaatgag tacaacagga attggagaag gtgtagctat acctcatgct aaaaattctt
    21241 cagttactaa agcttgtata gcagcagcag tgtcaaaaga aggtatagat tatgaatcgt
    21301 ttgacggaag tttatcaaat ctatttttta tgatagctgc accagacgga gctaacaata
    21361 ctcatcttga agtattatca agattatcta caatacttat ggatgaagac tttagaaata
    21421 aacttataaa ttcaagctct gaaaaagaat ttaaggaaat aatagataaa aaggaaagag
    21481 aaaaattcag tgaagaatat caagatgaga aagttactga aaaaaatata atagatacta
    21541 aagagaatga tgctaataag tatcctaagg ttttagcagt aacagcatgt ccaactggaa
    21601 tagcacatac atttatggca gctgaaagtt taaataaaat ggcagaaaac aaaggtgtat
    21661 caataaaagt agaaactaat ggttcagcag gtgttaaaaa taagcttaca aaagatgaaa
    21721 tagaaaatgc aacatgtata atagtggcgg cagataaaaa tgttgagatg gctagattta
    21781 atggtaaaaa agtcataaaa actaaggtgg ctgatggtat acacaaagcg gaagaactta
    21841 tagacaaggc tgtaaatgga gatgctccaa tttaccatgg aggagatgga agtcacaacg
    21901 aatcaaatga agaaagtgaa agtggattta gaaaagtata caaacactta atgaatggtg
    21961 tatctaatat gttaccattt gttattggtg gagggatact tatagcgata gcctttttac
    22021 ttgatgatta tactattaac ccttcaaact ttggttcaaa tacacctata gcagcatttt
    22081 ttaaaggaat aggagataaa gcttttggat ttatgttacc tgtacttgct ggatatatag
    22141 catactctat atctgataga ccagcgtttg ttgtaggatt tgtaggaggt gctctagcag
    22201 gtgatggtgg ttcaggtttt ttaggtgcac tacttgcagg ttttatagca ggttatttag
    22261 tagaagggct taagaaaata tttagtgtac taccagcttc attggaagga ataaaaccag
    22321 tattgttata ccctttactt ggaacacttt tgatgggaat tataatgaca tttttagtaa
    22381 tacctccagt tacagcaatt aataatgcaa tggttggatt tttaaatggt ttaggtggaa
    22441 cttcaaaaat agttttagga ttagtattag gtggaatgat ggctgtggat atgggtggac
    22501 ctgtaaataa agcagcatat gtatttggag ttgcatcact tgaatcaggg cagtttgaaa
    22561 taatggcagc agtaatggct ggtggtatgg ttccgccact tgctatagct cttgcaacta
    22621 cattttttaa gaatagattt actaaagaag aaagagattc tggtaaagtt aattatgtaa
    22681 tgggattatc atttgttact gaaggagcta taccttttgc agctggagac ccacttcatg
    22741 ttataccagc ttgtgttgga ggttcagcag tggcaggagc acttagtatg ttgttcaacg
    22801 cagctcttcg tgcacctcat ggaggagtat ttgttatacc agtggttacc catccatttg
    22861 catatatatt agctatagct gtaggtgctt tggttggaat gatgctttta gcattactta
    22921 aaaaaccatt aaatcaagaa gtatagcaat taaaggatat tcaagaactt aaaatatgat
    22981 gttttataaa aattaatata ttgctgaatt attttaaaat aaggatttta tgaggctgtt
    23041 atataacgat ttgtaattgt tatcttgaca gtcttttatt tttatataag taaaataagt
    23101 gtgttttgct ttatttgtat ttaaattgtt tttaagttag aatataaaga aaattatata
    23161 ttattttaat attcactcga actagaaaat aatatttgtt gtattttttt gtatataaaa
    23221 tatattgtaa tattaaaaaa ataatagtaa actgattgca taaaaatgat ttttatataa
    23281 aatttaagca gaagaataaa tttctaacga aattggatat ttcttctgta aatacatatt
    23341 caaaaaaaga attataagag tttagtcagc agtcgtgtaa gtaataagga ctttataaat
    23401 atatagaaat ataatgatat taatataacc aagcgatttt taatttagct ttttaataag
    23461 cttatttttt atactattta taataaataa actccatgat gggaaaacta ttactattta
    23521 atatgtaaag gagtatttta aatgaatgaa tcatattggt ttttaaactc aagtccaaaa
    23581 gaatataaca aattaggtga aaatataaaa acagattgtc ttatagtagg tggtggaata
    23641 acgggattga caactgcata tttattagca aaagaaggta aaaaagtagt gcttgttgag
    23701 gctgataaaa taggatatgg aacttctgga aggaatactg gtaaggtaac ttgtcagcat
    23761 gatatatttt actctaagat agagaaaaaa tatggattag ataaagcaaa atcatattat
    23821 aatgcaaata atgaagcttt aaatttagtt gaacaaataa tagaagaaaa caatataaaa
    23881 tgtgatttta aaagggaaac ttcttttgta tttacagaaa aagaggatac tataaaggat
    23941 attaaagatg aatatcgtac atgtaaaaaa ataggaataa attgtgagta tcatgaaact
    24001 atagaaaata ttccattaga tataaagggg gctattagtt ttactaatca aggtcaattt
    24061 aacccaaaga agtatattga tggattggca aaagcagcag taaatttagg gctaaaaata
    24121 tatgaaaata caccagtagt agaccttgaa aaaggaaaaa tatgtagggt taaaacaaga
    24181 gaggataata taatagaagc tgagaatgtt ataatttcat ctcatagtcc atggtatgat
    24241 ggattgaatt tttattttgc aaaagaatat gcagagcgtg cttatttaat ggttgcagtt
    24301 ttggaaaata aattagcaga tggtatgttt ataagtatag atgacccatc aataactttt
    24361 agacaatata atgatggaag tgaaaattta ctgatttttg gaggaggaga ccataaagtt
    24421 ggtcagggag gaactgagaa agaaatattt gatgatttag agcattatgg taaagaagtc
    24481 tttaaggtaa aagattttaa ggggaaatgg tctgctcaag ataatatgag ttttgacaat
    24541 gttccttata ttggttatat caacaaaaga gaagacaata tttatgtagc tacagggttc
    24601 tctaaatggg gaattactaa tggaactgct gctggaataa taataaaaga tttaataata
    24661 aataataatt ctgattataa agatactttt aatccatcca gactaggtag ctacttttca
    24721 aaagatttta taaaggaaaa tgcaaacgta gcaataaatt atgtaagtgg aaaattaaaa
    24781 ataggtagtg gagatatgcc taaaaataat ggagaaggaa agattgttaa tattgatgga
    24841 aaaagatatg gtgtatataa ggatgataat ggagattttt atattgtaga cactacatgt
    24901 actcatttag gatgtgaact taattttaac agtgaagaaa aaacatggga ctgtccatgt
    24961 catggttcta gatttgacta taagggaaat atacttgaag gaccagctct taagccatta
    25021 aaactttatg gacatggtga taatgatgtt aatcctaagt tattataaaa ttatttttag
    25081 gaaggtaaag tgtatatgaa taaactttta aagccaataa ctatactatt gtatatagtt
    25141 tatattttat ctgccgtatt ttttgtagca aacaaagaat atggaagtct aggtctagta
    25201 gcaattagtt tagttggtac tttcattttg agttttataa ataagcaaac tgaaagatta
    25261 ttgagtaaag aattatatat aatgcttgct ttatttataa tgttttcatc attgttaggt
    25321 acttgtttta atttttatga tataaattat tatgatgatt ttttgcattt atggtcaggt
    25381 ataatatctt gtattgtggc tttttctata attaaatact tttatacaca aagagagata
    25441 agtaaaatga gtaaagtgtt tttagttata tttttattta tgtttagtat gggagtagcg
    25501 agtttatggg aaataggtga atttttaatg gatacttttg ttgggactac tacacaggcc
    25561 ggagggttag aagatactat gattgatatg gtagatgctt taataggcac aattataact
    25621 attcctttta ta
//
LOCUS       DAEHWM010000052        25510 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.053, whole genome shotgun sequence.
ACCESSION   DAEHWM010000052 DAEHWM010000000
VERSION     DAEHWM010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25510)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25510)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25510
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.053"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            1..805
                     /locus_tag="KNP36_002202"
                     /pseudo
     CDS             1..805
                     /locus_tag="KNP36_002202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429874.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            1078..1371
                     /locus_tag="KNP36_002203"
     CDS             1078..1371
                     /locus_tag="KNP36_002203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874071.1"
                     /translation="MERGNRIICDQTGKILLQTGEATGDILEHDEITELHFVDIPYGS
                     IDYTRNRIIGINIETKEPILEEIPTFISDEEKRIQELENQILLNENEKVGGIL"
     gene            1371..1553
                     /locus_tag="KNP36_002204"
     CDS             1371..1553
                     /locus_tag="KNP36_002204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015981517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874072.1"
                     /translation="MNINNVVVRILAERILNKGLNPLKNRVFELDDVTNTEYRMAVEN
                     YIIEHSEVVEGAELTK"
     gene            1594..1824
                     /locus_tag="KNP36_002205"
     CDS             1594..1824
                     /locus_tag="KNP36_002205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin XhlA family protein"
                     /protein_id="HBF0874073.1"
                     /translation="MNEELVKEKISTLETRVKEHGKQIDRIEIEQAKFAIQIQNLCSD
                     IKNLTGVLKWLVGVIITTLVGFFIFAIQKGIF"
     gene            1844..2101
                     /locus_tag="KNP36_002206"
     CDS             1844..2101
                     /locus_tag="KNP36_002206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HBF0874074.1"
                     /translation="MDNLISFIPEQLLLLVVALNVLGFGFKKYKQLDNKYIPIILLVI
                     GIGFSIWMLGFNPSSILQGILCWGVAIGANQVYKQLKDGDK"
     gene            2101..2907
                     /locus_tag="KNP36_002207"
     CDS             2101..2907
                     /locus_tag="KNP36_002207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0874075.1"
                     /translation="MKIAIVPGHTLSGKGTGATGYIDEGKENRILTDLIVKWLKQGGA
                     IVYTGKVDKSNNYLAEQCKIANRQNVDLAVQIHFNANKTTLNPMGTETIYKTNNGKVY
                     AERVNDKLATVFENRGAKSDVRGLYWLKHTKAPAILIEVCFVDSKADTDYYIKNKNTV
                     AKLIAEGILNKNINNKENGEGKIMYKHTIVYDGEVDKIPATVVGWGYNDGKILICDIK
                     DYVPGQTQNLYVVGGGACEKISSMTKENYTMIKGNDRFDTLHKVLDFIDR"
     gene            complement(2953..3165)
                     /locus_tag="KNP36_002208"
     CDS             complement(2953..3165)
                     /locus_tag="KNP36_002208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874076.1"
                     /translation="MTWKNEIKSILVKENISMNELNNLMNEHNNKNNTVENLRQKINN
                     ETMKYSEILTIANLIGYEVVWKKKEK"
     gene            3344..4177
                     /locus_tag="KNP36_002209"
     CDS             3344..4177
                     /locus_tag="KNP36_002209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874077.1"
                     /translation="MKILFKEAHKMAREIKRKYSNVDYKVQFSLCLSFLNKKGDIKLK
                     ELKGSEKQIIWANDIRTDILNLTNELEKSKIERIKNEDYKIKDMSIEEMTERCKRKFE
                     RIREAISNIENAKFFIDNFRNVLKYNSLNQKAFHINQILKDSQFAKENRNWSFLQGET
                     QASYRLKKVKDYSISYEEAKKIAKEINFNDNWSNEIKENVLEIVEIFDDAVKQATSTE
                     YIEKAKKYIIETLIQKNAQFYRNGFADIKKKQIENYRKIESDERKIEIAYQVFRDGVE
                     C"
     gene            4254..4757
                     /locus_tag="KNP36_002210"
     CDS             4254..4757
                     /locus_tag="KNP36_002210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009900694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874078.1"
                     /translation="MNIDFSTILDLKVNKENVKMIEKEINKINNDIFDISLKDCANGH
                     IGSVKETVGKSLNIETWGHGEINSKIGIRLRFNFYYSKGDKVDIENIENILIYVNSLC
                     SKNVESDLIANVRPKFYKLEEKYSTRIEKCEIRHEFIGINKQEIKEFLEYLTEIEKSE
                     RTVIYKK"
     gene            4789..5259
                     /locus_tag="KNP36_002211"
     CDS             4789..5259
                     /locus_tag="KNP36_002211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874079.1"
                     /translation="MDKKEAKKFLKVIDMNIDKIEEEAIKAFKESCLIKETNDIKIYI
                     DIQGKVEAIAIQAYAKLLDDDKEINIFTSRQTGNNLDDMFGEIYYVNDYEEFENWCEN
                     KCESLNWDSYKKFNKENFEEIAERNIDDSTSVFLEELREGIESCKQELQNIVEN"
     gene            complement(5568..5873)
                     /locus_tag="KNP36_002212"
     CDS             complement(5568..5873)
                     /locus_tag="KNP36_002212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874080.1"
                     /translation="MNVEQSKSKKVYLNIGEELSKKMTKSELNKFSQELANYLQYAGL
                     DKNMKIKLFQTILEMVARKKITLSSDSEFTEGILQSDEAEMTTNVGFIIEGLSYHND"
     gene            complement(6083..6283)
                     /locus_tag="KNP36_002213"
     CDS             complement(6083..6283)
                     /locus_tag="KNP36_002213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874081.1"
                     /translation="MCFKTYVLKRVVNNNQLEITRSFDLDNLICTATEILKDNEIDLI
                     IIDEKNNVVWKNEKSTPQQENA"
     gene            complement(6416..6565)
                     /locus_tag="KNP36_002214"
     CDS             complement(6416..6565)
                     /locus_tag="KNP36_002214"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874082.1"
                     /translation="MFKNKMDKCTHVLTAYISSSYDYYNFLDTQLDDFILEYGENVVS
                     LVYTK"
     regulatory      complement(6619..6716)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            6925..7314
                     /locus_tag="KNP36_002215"
     CDS             6925..7314
                     /locus_tag="KNP36_002215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0874083.1"
                     /translation="MKQQEVVNKLRRGELMLMEYLWRKNSILSKKEIIEAMKEKYKWR
                     KSTTEILLKRLVKMKTLKKKRIGFQFSYEVLVTKKEYLNAIKEDRKVTKYDSFFIRMF
                     TTMHKKEKMTEEQIKKYIENMEKIGKE"
     gene            7408..7791
                     /locus_tag="KNP36_002216"
     CDS             7408..7791
                     /locus_tag="KNP36_002216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0874084.1"
                     /translation="MGFKKLPDSELKVMKFIWGLDGNKVASGEVVEAMKQIYDWNKNT
                     TLTILSKLAKKNYLYSQKTSKCTYYTIAVREKDYLKVETKKFFSFFHNNSLKSFFTAL
                     NDEENLSDDKLDMLEEWVKNWEEDE"
     gene            8470..9900
                     /locus_tag="KNP36_002217"
     CDS             8470..9900
                     /locus_tag="KNP36_002217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0874085.1"
                     /translation="MILNQIFIEAGGIMRNKIIIGITFLLVLLMSGCASKQTAEINVL
                     ATTDLHGVIPYELTSYVKEERKKDKNLTLVDAGDFFDSGEVFGSSMDSYFSARYKDGD
                     NNTESYIETPISKDMKEVGYDVAVLGNHEFISNNKFYLDNMISDFEKQKINILSANTY
                     KKNGDSYTKPYIIKNINTPEGNVKLGILGLTIKEVGERKQWKDGKLVDSKSLELKDQE
                     GYNGELYMNDLVEDAKKWVSIMEKEKPDIIVAVAHTGEKPKKPKNPGNRIQDLAQQVD
                     GIDAIVAGHNHVQIEQHDYKNKSGENVIVTEPGKHGECISKINFKLEKNNDKWNIVDK
                     SSKLIKFEKNQESDKFGEFISSINKVSKDKKEIRLSEVKTPEWDKIYVFKSGTSADDI
                     YKTIGYKWRNISSPKSDGMVQIVVMNNNKPVSYIYGEAEVMPINIKCDESEYKDNVVT
                     IYPNKNDKFKIEKGKQEYSINLKHIQ"
     gene            complement(10048..10398)
                     /locus_tag="KNP36_002218"
                     /pseudo
     CDS             complement(10048..10398)
                     /locus_tag="KNP36_002218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904812.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
     gene            10393..10914
                     /locus_tag="KNP36_002219"
     CDS             10393..10914
                     /locus_tag="KNP36_002219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /protein_id="HBF0874086.1"
                     /translation="MFSIGGGYAIIPLIQEKVVNQTGWISEKIFTDIITISQMTPGPL
                     AVNTSTFVGLQIGGFWGAVAATLGCVLCGVVISLFLYNFFQKHQNSTYIFEILNGLKS
                     ASLGLIISAAATIIILALFGTNKVYFNSIFEMLNWTALIIFFVTLLIVRKWKINPIVI
                     IIMSGILGIFFYL"
     gene            complement(11043..11279)
                     /locus_tag="KNP36_002220"
     CDS             complement(11043..11279)
                     /locus_tag="KNP36_002220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425320.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874087.1"
                     /translation="MLECFIAKDSKIKDGVNIPTLVFKTLHDRYFKTQYFDSYYNSLK
                     CKKKLVEINNVHNSYYIDSKKFCQEAYDWFVENQ"
     gene            complement(11589..15017)
                     /gene="uvrA"
                     /locus_tag="KNP36_002221"
     CDS             complement(11589..15017)
                     /gene="uvrA"
                     /locus_tag="KNP36_002221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBF0874088.1"
                     /translation="MKINNYKNQSIITNPKKFENKYQDLPKTPIELLKVVQSLVIHGD
                     QGKLYGISFNKQQSDEELLRTIPQMLKRIFEINSNPLTIPRNPKQRLVGMCRDYSLLL
                     VSLLRYRGFEARMRAGFANYFESELTYEDHWLVEYYDTLTKRWIRIDAQIDDIQKNYF
                     QINFDTHDVGKTDGFLTGSEAWIRCRQGHAHPDDFGYNKNWKGWHSVKGNLLHDFNNM
                     IGLELLPWDLWTELSSKKYNQLTRAEKNLLDEMAEILSSGNIKIEALNLLIEKLPEDY
                     LKSIFSQLKILGISEIKELGNPLELEKKFKFTKAINKSIKNSLCHNKSSIYLKGGRQN
                     NLKDVEVTIPKNQITVITGVSGSGKSSLAFDTIYEEGKRRYFENLSNGAKLSEQLQKP
                     EFDLLQGLTPTIAIEQKKGSQNPRSTVGTLTSIWDYLRMLFVSIGKSYCPYCKIPLEK
                     KNNTKNYCPHCQTIFSKINTSTFNANSHTGACHDCNGLGFTYQVNPQLIVKDPTISIL
                     DGATYYFGKLRGKKPNGNWMVGELYAIAKDKNIDLDIPWNELPRDFIDAILYGTDDKI
                     YEFSFESKGRESKIRRPASGAINHIQRLFRESSSENNTLHQYMNKIPCNTCGGELLCI
                     EARFTTIKGYRFPELTKMTIEQLWNWLCELPNHLQKNELSLVNDILTELKIRVSYLLK
                     VGLSYISTDRTAPTLSGGELQRVRLSSQLGSELVGLTYILDEPSIGLHPRDHNLIIKM
                     IEELRDKGNTVIVVEHDKDTILSADYIIDVGPSAGTKGGFIIAEGTTQEIIKNPNSIT
                     GKYLSTYNKISSQNKIIPSKWLSLKGCHANNLKNIDVEIPLNCMCSITGVSGSGKSSL
                     VFHSLLPALEEKLKQKSIPDKNYTEFTGFDAIDDFILMDQAPIGKSSRSTPATYINIF
                     DEIRSLFAETPQAKQKLLDESYFSFNSKKGQCPNCQGLGKTKIILQYMSDQWVTCSEC
                     QGKRYQKEILSIQYKGKTIADILDMEVAEAKTFFSDCSDIYRKLSLLDEVGLGYLKLG
                     QNTLGLSGGESQRIKLAKELGTKTKKRMLYILDEPTTGLHFKDIENLLITFRKLVNEQ
                     HSLLIIEHNTEVIRASDWIIDIGPDSGINGGEIVASGTPDEIKINPNSITGHFI"
     gene            15336..17570
                     /locus_tag="KNP36_002222"
     CDS             15336..17570
                     /locus_tag="KNP36_002222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0874089.1"
                     /translation="MKLSRYKKNSLVLSIILCSLIISILVITVFNTVKLHNISNKQSK
                     NYLNDVSTQIVMNVDSKIKFILSDLRIMADFIKQYEGDSRYEYLSKRKTSYKYYDVGI
                     IDLEGKAEFLSGKKFDLKNTVSYKKGIEGKEYSEVIESMGFVLYSVPIFNDNHEVSSI
                     LIGVSNKESMNEILNIDNFNGKGTIEIINSKGKPLFIGKNTELIKDLSHKYKSSGDEP
                     WAQKMLEDFKNDKSGNITITSSKGVQCLLTYHPITRGLNDWHFLLIVPEDAVLGELNK
                     LNSFTITMTFIITCIIGIITLILYIIRRKYVNQIENIAYLDSITNGINSTKFSMLVKP
                     LISESPDSTYMMIAMNIKDFKLINDCFGSEKGNMTLKHLYNILYKNIDENEEFVCRHD
                     ADLFYLLIKNRPVLEALELLYKIEADTNYFNKNRENPYFLRLSVGIYTIENHNEDLIT
                     IQDHANTARKSFNKTHQSDFSFYSDIERKRLISEKEISNLMEKALENKEFFMCLQPKI
                     DIKSGKISGAESLVRWKNSEKGIIYPSDFIPLFEKSGFICKLDLYILEETCKLISKWI
                     KEGKEVLRISVNVSRQHLNDKLFLEKYKHICNKYNVPTCLIDLELTESIFLENPEAID
                     IIEDIHSNGFKCSIDDFGFGYSSLGILKDFKVDIIKLDRSFFVSKNNIDRGKVVIKSI
                     IELSKRLGMKVTAEGIEELEQVEFLKNVGCDYIQGYVFSKPLLISDFENFAYENNKIK
                     NIHY"
     gene            17826..19856
                     /locus_tag="KNP36_002223"
     CDS             17826..19856
                     /locus_tag="KNP36_002223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0874090.1"
                     /translation="MISGRMLLIMNFLKGKNKTSYKDISKQLSIEERKVRYDINNLNI
                     VLRSLNKSVIQKMNKGVLIIPDDFQVVCINNNEYVFSLTERVSIMKIISMFKIDNLNL
                     EKLSKEFQVSRSSIKNDLNVLSSELERNQITITYDKSFKISGEEDIIYKQRLNILKSY
                     SYLFGKEKSDLSVFEKYLVNVIEKIFKGIYLIDIYNWSMNLLLQMGWTLNDESFTWYV
                     SNIFLFTWYIHSDEKHPLESASLSEPCFENKFDQEFETIIQKKLTKEQIFLLKSFVFF
                     TNKYASLNEDMDLISTEIIVQDLIYNMSEILEISFKEDMILYKGLLNHIAPLIERIKQ
                     NIQIYEELLHVIPDKYQYVLEATKVSIQKNRVLSQIKNENETILLAIHFLGSIHRNER
                     NNYKNILLVCGFGYGVIAMLKDSLVNDYQINIVESIPSYKLQDYKEWESIDFIITTSK
                     IVIDLPKTIIEINPFLQEEDYLKFEEKGIKRKNVLTNYMSIKKRLDFLEEDAQKRVLS
                     IICQELGYSDERILFRQLNLSDLIGIDTIRIIDGDMKWEDAVKISSNILANCDFVSAQ
                     YAENIIDILKNVGFYAVKDNEFALLHGNDSSLVKVSSISLLICKEAVSFGDKKVKIIF
                     CLASRDKKEQIPAIINLTKMVYKTNFIAMLESAKTKEEAEVLIHKYEKEVTV"
     gene            19853..20305
                     /locus_tag="KNP36_002224"
     CDS             19853..20305
                     /locus_tag="KNP36_002224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0874091.1"
                     /translation="MNKLVNVKCSFKIHVNSKEEAIISLVDVVSKEGYLIDKNQFLKD
                     VLKREETLSTYIGHGIGLPHSQSVGVKNSCITIGKLDTPIEWTEEGEKVDLIFLISVT
                     KDNENNLHLKILSKLARLLMHESFRNQIRCSDEQTVYNLIKEKIEEED"
     gene            20307..21362
                     /locus_tag="KNP36_002225"
     CDS             20307..21362
                     /locus_tag="KNP36_002225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit EIIC"
                     /protein_id="HBF0874092.1"
                     /translation="MRILKFLQKHLMTATSYMIPFVVAGGILFALSVTLSGQAAVPET
                     GWLAKLNQIGAAGLALFIPILGGYIAFSMADKPGLAPGMIGAYLAKEVNAGFIGGIIA
                     GFIAGFVVLQLKKIKLAPTMRTLGSIFIYPLVGTLITGGIIVFLIGEPIASFMTWMTN
                     WLNGMSGVSKIPLGGILGGMIASDMGGPINKVAATFAQTQVDTLPYLMGGVGVAICIP
                     PIGLGLATLLFPKKFSKEERDSGKASLLMGCVGITEGAIPFATSDPVRVIPCIMAGSI
                     VGNIMAFLLGCLNHAPWGGLIVLPVVDNRLGYIASVLTGAVVVAVLMKLVKKDVKEDE
                     EIEEDLDESIELIFEEL"
     gene            21429..21737
                     /locus_tag="KNP36_002226"
     CDS             21429..21737
                     /locus_tag="KNP36_002226"
                     /EC_number="2.7.1.202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose-like transporter subunit IIB"
                     /protein_id="HBF0874093.1"
                     /translation="MKIVAVTSCPSGVAHTYMSAESLELSAKKFGIEIKVETQGSSGI
                     DNELSLKDIDEATCVILTNDVEIRNMERFKGKKVVRMSVSEIIKKSDALIKKIKDTFQ
                     "
     gene            21841..23106
                     /locus_tag="KNP36_002227"
     CDS             21841..23106
                     /locus_tag="KNP36_002227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II D-tagatose-bisphosphate aldolase,
                     non-catalytic subunit"
                     /protein_id="HBF0874094.1"
                     /translation="MKKLPIKTVVQRLLNLQEEGKSATLLGIGPMSPNLLQASFELAK
                     DDDFPLMFIASRNQVDADELGGGYVNGWNQETFTKDIKKVADKVGFDGLYYLCRDHGG
                     PWQRDKERNDHLPVDEAMELGKKSYLADIEAGFDLLMIDPTKDPFEIGKVIPLDVVLE
                     RTVELIEYCENERKRLNLPDIGYEVGTEETNGGLTSTETYETFITRLKVELDNRGLPM
                     PTFIVGQTGTLTRKTEQVGTFNFRNAYDLAQMAKKYGVGLKEHNGDYLDDVTLLEHIP
                     SQIIATNVAPQYGTEETRAYLKLAEVECKLEKEGLVEKTSNIRHVLLVNAIECGRWRK
                     WVVGEQKNLTTEEIFKDEVLSNEILDIAGHYTFNNDDVKKEIEVLYDNLSKNNIDGQR
                     FVVDHIKRPLRDYAECYNLKGVTTRILNK"
     gene            23194..23910
                     /locus_tag="KNP36_002228"
     CDS             23194..23910
                     /locus_tag="KNP36_002228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HBF0874095.1"
                     /translation="MINLIFDVDDTLYNQLTPFYTAYNKVFSSIKDISIEDLYMSSRK
                     YSDEVFHMTENGEMPIKEMHIYRIMKAFEELGNSITEKDAQSFQDEYIYQQSQITLIP
                     EVERILNFSKERNINLGIITNGPSNHQRMKLKQLNIENWVDKSNIFISSEVGFSKPDT
                     NIFRVAENVMNLDRENTYYVGDSYRNDVLGAKKAGWKSIWLNHRGHELEELFYKPDFV
                     ILEHKDLISLFIKICSYKNM"
     gene            complement(24105..24398)
                     /locus_tag="KNP36_002229"
     CDS             complement(24105..24398)
                     /locus_tag="KNP36_002229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein"
                     /protein_id="HBF0874096.1"
                     /translation="MRNMIENLIKNNTYIDDKVIMLSMLSSAKASANMYLNSALTSST
                     PELRAIYSASLTQMVEGHTALTELSINKGWVKPYDKPIQQLTCSYKESQNVID"
     gene            complement(24404..24619)
                     /locus_tag="KNP36_002230"
     CDS             complement(24404..24619)
                     /locus_tag="KNP36_002230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874097.1"
                     /translation="MRILSETEKISLAAIIKMESDGLLMQRAINMLISDEDLKRQSES
                     SILATEGRIKAIQQFIVENEILISEEV"
     gene            25066..25464
                     /gene="tnpA"
                     /locus_tag="KNP36_002231"
     CDS             25066..25464
                     /gene="tnpA"
                     /locus_tag="KNP36_002231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="HBF0874098.1"
                     /translation="MYKSNKNIVYDCKYHIVFCPKYRKPVLVGEVEKMLKEILPYKAD
                     ELGAEIIEMETDKEHVHLLISCDPQYGIHKVVKGLKGFSSRVLRENFPHLKSSMPSMW
                     TNSYFVGTVGSVSLEVVKQYIENQQVRTKK"
BASE COUNT         9784 a         2899 c         4110 g         8717 t
ORIGIN      
        1 gggagcaggt ggaggtggaa gtggctacgt attaactaaa gatagttata agcctactgg
       61 ctacacacca acatctgaat attattttga taatgttgtt atggaatctg gtggaaatac
      121 tgctggtgct tatggttatg ctaaaataac attactacaa gcattaccat ttttaacagt
      181 atcttcttat aattccatta cagctacatt taaagctgac cacacagacc ctacattgct
      241 tacaaaaata gaatatttta tagatgatgt gttaaaagaa actataacaa cagatttaac
      301 aacagagaaa acaattaact atacactaga agataatgca ctacacacac ttaagatagt
      361 tgttacagac agtaataatg ctacagcaga aaaagtgtta agtataagta agaatataat
      421 gccattgccc gaagatgtga atctgcaaga catatcttct aaactaattg aagttaatgc
      481 aggatttaaa actggaaaaa caagtattat aaacacttta gcattaaaaa atatagaagc
      541 aaatttaaat aatacattag ttgaattatc agagaaaata aaaacaggtt ttgatagttc
      601 agatgctact gctgaacaac ttcaaaatca gattactaat ttaaataatc agttaagcca
      661 acgtaaaaga tgggctaagg gtacttacac ttttactcaa agtgattatg aaaattttta
      721 ttcaaggtat tcaagtgctg aaaattatgc taagagtctt actgttccta ttaatttaaa
      781 tttcatccct agtcttgtca ttgttgaaaa actttgtttt tatggaaatg ggtatactgt
      841 taatttttat gctattaata atttaaatca acttgcttct gttggtcgtg ttcctaagag
      901 tagtggagaa tatcgttttt gtgcttttat gtttgtaaaa actattacta gcaaagaatt
      961 ttctttatat acttatcgag atgaatacac tgatagtagt agcgtagtat accgttgtaa
     1021 agtcggagaa agttttacat ggtatgctta tgaataatat gaaaggtggt aatttaaatg
     1081 gaaagaggaa atagaattat atgtgaccaa accgggaaaa tattactcca aactggagaa
     1141 gcaacagggg atatattaga acatgatgaa ataacggaat tacattttgt tgatattccg
     1201 tatggaagta tagactatac aagaaataga attataggta taaatataga aacaaaagaa
     1261 ccaattttag aggaaatacc aacatttatt tcagatgaag aaaagagaat acaagagtta
     1321 gaaaatcaaa ttttattaaa tgaaaatgag aaagtaggag gaattttata atgaatataa
     1381 ataatgttgt agtaagaata ttagcagaga gaatattaaa taagggatta aatcctctaa
     1441 aaaatagagt atttgaactt gatgatgtta ctaacacaga gtacaggatg gcagttgaaa
     1501 actacattat agaacatagt gaggtagtag aaggagcaga acttacaaaa taggtaatgt
     1561 tcttttttta atacaaagca ataggaggtt ttcatgaatg aagaacttgt gaaagaaaaa
     1621 ataagtacac ttgaaacaag agtaaaagaa cacggcaaac aaattgatag aatcgagatt
     1681 gagcaagcaa agtttgctat acaaatacaa aacctatgta gtgatataaa aaatctgaca
     1741 ggagtactca agtggcttgt aggagttata attacaactt tagtagggtt ctttatattt
     1801 gccatacaga aaggaatatt ttaattaatt aggaggttaa gatatggata atttaataag
     1861 ttttatacca gagcaactgc ttttattagt agttgctctt aatgtattag gatttggatt
     1921 taagaaatac aaacagttag ataataaata cattccaatc atattgcttg tgataggaat
     1981 tggattttca atatggatgt taggatttaa tccttcatca attttacaag gaattttatg
     2041 ttggggagtt gcaatagggg caaatcaagt ttacaaacag ttgaaggatg gtgataaata
     2101 atgaaaatag caatagtacc aggacacact ttaagtggaa aaggaacagg agcaactggc
     2161 tatatagacg aaggaaaaga aaatagaatt ttaactgatt taattgttaa atggttgaaa
     2221 caaggtggag ctattgtgta tactggaaaa gtagataaat ctaataacta cttagcagaa
     2281 caatgtaaaa ttgcaaatag gcaaaatgta gacttagcag tacaaatcca tttcaacgca
     2341 aataaaacaa ctctaaatcc tatgggtaca gagacaatat acaaaactaa caatggtaag
     2401 gtatatgccg aaagagttaa tgataaatta gcaacagtat tcgaaaatag aggtgcaaaa
     2461 tcagatgtaa gaggtcttta ctggcttaag catacaaaag ctccagcgat attgattgag
     2521 gtgtgcttcg tagatagtaa agcagataca gattattata ttaaaaataa aaatacagtt
     2581 gcaaaactta tagcagaggg tatattaaat aaaaatataa ataacaaaga gaatggtgag
     2641 ggaaaaatca tgtacaaaca tacaatcgtt tatgatggag aagttgacaa aatacctgca
     2701 actgtagttg gctggggcta taatgatggg aaaatactga tatgtgatat aaaagattat
     2761 gtacctggcc agacacaaaa tctttatgtt gttggtggtg gagcatgtga aaagataagt
     2821 tctatgacta aagaaaatta tactatgata aaaggtaatg atagatttga tacacttcac
     2881 aaagtattag attttattga tagatagatt agaaggtagc aactagttag ttgttacctt
     2941 ctttttttat gtctactttt ctttcttttt ccaaacaact tcatatccta tcaaattagc
     3001 aatagtcaag atttcactat acttcatagt ctcattattt attttttgtc ttaaattttc
     3061 aactgtatta ttcttattat tatgttcatt cattaaatta tttaactcat tcatgctgat
     3121 attttctttt acaagaatac ttttaatttc attcttccat gtcatttttt cgcacctctc
     3181 ttatttatat aataacataa aaaaattaaa agtaaaagaa taatctacgc taatcaaagt
     3241 tatatttttg gaaatcaaag aaaaaacttt gaaaaagtgt tgacttagat attcatatag
     3301 attataatat aattaacaaa taaaacaagg gggtaagcaa agaatgaaaa ttttatttaa
     3361 agaagcgcat aaaatggcaa gagaaataaa aagaaaatat agtaatgtag attataaagt
     3421 acaatttagt ctttgcttat cattcttaaa taaaaagggg gatataaaat tgaaagaatt
     3481 aaaagggtca gaaaaacaaa ttatttgggc taatgatata agaacagaca ttttaaattt
     3541 aactaacgaa ctagaaaaaa gtaaaataga aagaataaaa aatgaagact acaaaattaa
     3601 agacatgagt atagaagaaa tgacagaaag atgtaaaaga aaatttgaaa gaataagaga
     3661 agcaataagc aatatagaga atgctaagtt ctttatagat aattttagaa atgttttaaa
     3721 gtataattct ttaaatcaaa aagcatttca tataaatcag atattaaaag attctcaatt
     3781 tgcaaaagag aacagaaatt ggagtttttt acaaggggag acacaagcat cttatagact
     3841 taaaaaagtt aaagattata gtataagcta tgaagaagct aagaaaatag ctaaagaaat
     3901 aaattttaat gataattggt ctaatgaaat aaaagaaaat gtacttgaaa tagttgaaat
     3961 atttgacgac gcagtaaaac aagctactag cacagaatat atagagaaag ctaaaaaata
     4021 cataatagaa acattaatac aaaaaaatgc acaattttat agaaatggat ttgcagacat
     4081 taaaaagaag cagattgaaa actatagaaa aatagaaagt gatgaaagaa aaatagaaat
     4141 tgcataccaa gtattcagag atggcgtaga gtgttaaaag tttcaacttg atacaaatat
     4201 agttcaccat tgaatgctat aattaaaata aaaaataatt ggaggtttaa aacatgaata
     4261 tagattttag tacaatatta gatttaaaag ttaataaaga gaatgttaaa atgatagaaa
     4321 aagagattaa taaaatcaac aatgatatat ttgatataag tcttaaagat tgtgcgaacg
     4381 gtcacattgg aagcgttaaa gaaacagttg gaaaaagttt aaacattgaa acgtggggtc
     4441 atggtgaaat taacagtaaa ataggaataa gattgagatt taatttttat tattcaaaag
     4501 gcgacaaagt agacatagaa aatatagaaa acattttaat atatgtaaat agcttgtgta
     4561 gcaaaaatgt agaaagtgac cttatagcca atgtaagacc taaattttat aaattagaag
     4621 agaaatattc tacacgtatt gaaaaatgtg aaattagaca cgaatttata ggcataaaca
     4681 agcaagaaat taaagaattt ttagagtatc ttacagaaat tgaaaagagc gaaagaactg
     4741 ttatatataa aaaataacta aaaaatggag gaaattaaaa tggataaaat ggataaaaaa
     4801 gaagctaaaa aatttttaaa ggttatagat atgaatatag ataaaataga ggaagaagct
     4861 ataaaagctt ttaaagaaag ttgtttaatc aaagagacta atgatataaa aatttatatc
     4921 gatatacaag gaaaagttga agcgatagca atccaggctt atgctaaact tttagatgat
     4981 gataaagaaa ttaatatttt cacatcaaga caaacaggaa ataacttaga cgatatgttt
     5041 ggagaaattt actacgtaaa tgattacgaa gaatttgaaa attggtgcga aaataaatgc
     5101 gaaagtttga attgggatag ttataaaaaa ttcaataaag aaaattttga agaaattgct
     5161 gaaagaaata tagacgatag cacatcagtt tttttagaag aattacgaga aggcattgaa
     5221 agttgtaaac aagaattaca aaatatagtt gaaaattaag tagaagagta ttattattaa
     5281 tgtatatagt atcgctttta agattaacta cgagggattt aaaatatttt ttaatttatt
     5341 tagaaataat attgtaataa gaatttttat attaactaca agggatttaa atgtcaattt
     5401 aatttataga gaaatgatat aatggtattt tttagattaa ctataaggga tttaaatatc
     5461 aatttaatct atattcacat gatataatat cacattattt tatattaact atgcggaaat
     5521 aaaagcagtg tatttaataa atacactgct tttttaatgc taaagattta gtcattatga
     5581 taacttaatc cttcgattat aaatcctaca ttcgtcgtca tttctgcttc atcactttgt
     5641 aatattcctt ctgtaaattc gctatcgctt gataatgtta tttttttcct tgccaccatt
     5701 tccaaaattg tttgaaatag tttaattttc atattcttat caagtccagc gtattgcaaa
     5761 tagtttgcta gctcctgcga aaacttattt aattcagatt tagtcatttt tttagataat
     5821 tcttctccaa tatttagata aactttttta gatttagatt gttcaacatt catttttttc
     5881 aacccctttt ttaagttata attcaattat attttaaaaa tgctaatact tcaaatataa
     5941 atatttttgt ttaagtatat aaaacatcaa taacattact caacacacct taaaattgat
     6001 ttaaatagct cttttttatg aacaaaatta atgatataat aaaaaataga agtgtattgg
     6061 tagtacactt ctatagttat aactaagcat tctcttgctg gggagtgctt ttttcatttt
     6121 tccaaacaac attatttttt tcatcaataa ttattaaatc aatctcatta tcttttaaaa
     6181 tctctgttgc agtacaaatg agattatcta agtcgaaact acgagttatc tctagttgat
     6241 tgttatttac aactctttta agtacataag tcttaaagca catttatatt attatccttt
     6301 ctcacaaaaa tactttaatt aattttttaa catagtaata tttaaaagta gataaaacta
     6361 aaaagggttc tctagaaatc aatgtctatc taattatact tacttaccaa taccatcact
     6421 tggtgtaaac aagactcact acattttctc cgtactctaa tataaaatca tctaactgtg
     6481 tatctaaaaa attataataa tcatacgaac tgctaatata agcagtcaat acatgtgtac
     6541 atttatccat tttattttta aacatataaa ttattatacc cctaaaaaac tttcataaaa
     6601 acaaaagaac aatatctctt tggcaactgg ctgacataac tcataagata tttatataag
     6661 tcttagtccc tatagctttg cgtcactaaa tttctctagt tttgccgatt tagttttatt
     6721 ctacaactaa aataatacaa tagaattagt tattattcaa caaaattatt tgaaaattta
     6781 ataattttat agatatgaaa gttattttct tctaagaaaa cagactaaat gcgtagaata
     6841 tttggtaaaa cttacctgta taaattgaaa tcagaaggtt ttattattga tttagattag
     6901 aacaatttga gggagtgaca taaaatgaaa caacaagaag tagttaataa actacgcagg
     6961 ggagaattga tgttgatgga atacttgtgg aggaaaaatt ctattttatc taaaaaagaa
     7021 ataatagaag caatgaaaga aaaatataag tggaggaaaa gtactacaga aattctatta
     7081 aaaagattag taaaaatgaa aacattaaaa aagaagagga taggttttca gtttagttat
     7141 gaagtgctag taactaaaaa agaatattta aatgcaataa aagaagatag aaaggtaact
     7201 aaatatgata gtttttttat acgaatgttt accactatgc ataaaaaaga aaagatgaca
     7261 gaagaacaaa taaaaaaata tatagaaaat atggaaaaaa ttggaaaaga ataatttata
     7321 tatatattaa ttatttttaa aataaatttg ttataatatt taaatataca taaacataca
     7381 taaatttaca aaaagggggt gtagcttatg ggattcaaga aattgccaga ttctgagtta
     7441 aaagtaatga agtttatttg gggattagat ggaaataagg tagcatcagg agaagttgtg
     7501 gaagcaatga aacaaattta tgactggaat aaaaatacga cattaacaat attgtctaag
     7561 cttgcaaaga aaaactattt gtattctcaa aaaacaagca agtgtacata ttatactatc
     7621 gctgtaagag aaaaagatta tttaaaagtt gaaacaaaaa aattctttag tttttttcat
     7681 aataattctt taaaaagttt tttcactgct ttaaatgatg aagaaaattt aagtgatgat
     7741 aaattagata tgttagagga atgggtgaaa aattgggaag aagatgaata aaatgaatgt
     7801 gatactaaaa tgatactaat atgttttata gcgtgttaaa aaatatagaa aatatagaaa
     7861 taatagaaga aaattaatgt aatagataag gttttatcag attaaaaaga aaatcaatag
     7921 aatgggaata aaatatagaa tgccaaaaat ccacataaat acaggattta aggtctctct
     7981 tacttctatg ttatactggt ttgatactat caatatttgc cagtatctta tggattaata
     8041 agtaaaaaac atcctgctga atgataaatt cagcggggtg tttttatttt gttttagaac
     8101 tcctttgctc tgaaactcga agtatttaac actgatgatt ttgttatctt ttagttcctt
     8161 ttgtgtcatg ctctgaaaga caaattgata caataaaaaa gtaatttctt aatcattgat
     8221 ggagatatgt atttatgtta ctcttgatgg taatttgagt aatattgttc atagcttttt
     8281 atattcaatt aattagaaaa ccatttggta taatcataaa taaacttgat gatataatag
     8341 aaaagattta taattattag aagtatataa aagtatttta tgtctatgaa atgtatgtct
     8401 ataaaacata tagatgactt ttgtatatta atgtatgaat attgatatta tagaagaatt
     8461 gagttgtcaa tgatactaaa tcaaatattt atagaagctg gagggattat gagaaataaa
     8521 ataattatag gaattacttt tttacttgta ttactaatgt ctggatgtgc ttcaaaacaa
     8581 accgcagaaa taaacgtatt agcaactact gatttacatg gagttatacc ttatgagtta
     8641 acttcttatg taaaagaaga aagaaaaaaa gataaaaatc taactttagt agatgcagga
     8701 gatttttttg atagtggaga agtgtttggt tctagcatgg atagttattt tagtgctaga
     8761 tataaagatg gtgataataa cactgaaagt tatattgaga cgcctatttc aaaagatatg
     8821 aaagaggtag gttatgatgt tgcagttctt gggaatcatg aatttatatc caacaataaa
     8881 ttttatctag ataatatgat atctgatttt gagaagcaaa aaataaatat tttatcggca
     8941 aatacgtata aaaaaaatgg agacagttat acaaaaccat acataataaa aaatattaat
     9001 acacctgaag gaaacgtaaa actaggaatt ttagggctta ctataaaaga agttggtgag
     9061 aggaaacagt ggaaagatgg aaaacttgtt gactctaagt ctttagaact aaaagaccaa
     9121 gagggctaca atggtgaatt gtatatgaat gatttagtag aagatgctaa aaagtgggtt
     9181 agtataatgg aaaaagagaa gcctgacatt atagttgctg tggcacatac aggtgagaaa
     9241 cctaagaaac ctaaaaaccc aggaaataga atacaagact tagctcaaca agttgatgga
     9301 attgatgcta tagttgcagg tcataatcat gttcaaattg agcaacatga ttataaaaat
     9361 aaatcaggag aaaatgttat agttactgag ccaggaaagc atggggaatg tatttctaag
     9421 attaatttta aattagaaaa aaacaatgat aaatggaata tagttgacaa atctagtaaa
     9481 ttaattaaat ttgaaaaaaa tcaagaaagt gataaatttg gagaatttat ttcttcaatt
     9541 aataaagtaa gtaaagataa gaaagaaata agattatcag aagtaaagac tcctgaatgg
     9601 gataaaatat atgtttttaa atctggaaca tctgcagatg atatatataa aacaatagga
     9661 tataaatgga gaaatatatc atctccaaag agtgatggca tggtgcagat tgttgtaatg
     9721 aataataata agcctgttag ctatatatat ggtgaagctg aagttatgcc aattaatata
     9781 aaatgtgatg aatcagagta taaagataat gttgtaacta tttatcctaa taaaaatgat
     9841 aaatttaaaa ttgaaaaagg taaacaagaa tatagtatta atttaaaaca tatacaatag
     9901 aaacttttat cttatttaag tttagattgt acttaaaata aagtgtgtat tattttaaaa
     9961 attgatgata attaaaatca caacattaag gaatagtaca cactttttat gctaaaaaat
    10021 agaatgttaa aaaattaaac ctttaaatta aagtacattg cttatattat ccaatattat
    10081 cttcaaaggt tgtgtaatat ttttatcctt atgtaatatt gctaacattt tattttccat
    10141 atctatccca tctaattcaa tcaatcgcaa ttttttatgt aagagtgaat ctaataataa
    10201 attttctggc aaaatggtta tacctaaccc tgcttgtgca gctttaataa gtgcaaaaga
    10261 attaacactt tcccaaacag gataagcttt ttggtttgaa agagataata cactgtccaa
    10321 agtatcgcga atggcacttc cttgctcacg taacaataac ggaaacgtgc ataactgtcg
    10381 tagagataag gcttgtttag tattggtggt ggttatgcaa tcataccttt aatccaagag
    10441 aaagtagtaa atcaaactgg atggataagt gagaaaatat ttacagatat tataactatt
    10501 tcacaaatga caccagggcc actggctgtt aatacttcta cttttgttgg acttcaaatt
    10561 ggagggtttt ggggagcagt tgcagccact ttaggttgtg tattatgtgg tgtagtaata
    10621 tctctatttt tatataattt ttttcaaaag catcagaact ctacttatat atttgaaata
    10681 ttaaatggtc taaaatcagc ttcattaggt ttaattatct cagctgcggc tacaattata
    10741 attcttgcat tatttgggac gaataaagtg tacttcaatt ctatatttga gatgctaaac
    10801 tggactgcac taataatctt ttttgttaca ctactgatag tacgtaagtg gaaaattaat
    10861 cctattgtga ttataataat gagtggtata ctgggaatat ttttttattt ataagttttt
    10921 gctaagtaaa ggatatctat ttttttatat cttaaatcca aatagccaat aaagtaaggc
    10981 tatttggatt tttaataaat tctgaaaaga taatcagaaa cctatataac atttaaatta
    11041 tatcactggt tttctacaaa ccaatcataa gcttcttggc aaaatttctt actatctata
    11101 tagtaactat tatgaacatt attaatttca acaagtttct ttttacattt tagtgaatta
    11161 taatagctat caaaatattg ggttttaaaa tatctatcat gaagtgtttt aaagacaaga
    11221 gtaggtatgt tgactccatc ttttatctta ctatcttttg caataaagca ttctaacatt
    11281 gtattaatta tctttgtact atttttccaa atatgaggat ttttcttttc aaatatttta
    11341 taaaattcat tatcatagac ttcattataa cctttatatt taggtggttt tactgttatg
    11401 tgaaaattag gaagaaactt aaagaaaaaa tataataatt tttatgttct gttttatata
    11461 ttattcatat tttatcacag ataatatact aaagttaatt tttttattgt acaactatta
    11521 taataattct tctataatat aagacattct ataattttat atttaagttc atgtgtattt
    11581 aattgttttt atataaaatg tccagtaata ctatttggat ttatttttat ttcatcagga
    11641 gttccagaag caacaatttc ccctccattt attccactgt ctggacctat atcgataatc
    11701 caatcagaag cacgtataac ctctgtattg tgttcaataa ttaaaagtga atgctgttca
    11761 tttacaagtt ttctaaaagt aattaacaaa ttttctatat ctttaaaatg aagtccagta
    11821 gtaggctcat ccaatatgta cagcattcgt tttttagttt ttgtccctaa ttcttttgct
    11881 aattttatcc tttgagattc tcctccactt aatcctaatg tattttgtcc aagctttaga
    11941 tatccaagtc ccacttcatc taataaggag agttttctat atatatcaga gcaatcgcta
    12001 aaaaatgttt ttgcttctgc tacttccatg tcaagtatat ctgcaattgt ctttcccttg
    12061 tattgtatag acagtatttc tttttgatat ctcttacctt gacattcact acaagttacc
    12121 cattggtctg acatatattg cagaataatt tttgttttac ctaatccttg acagtttggg
    12181 cattgcccct ttttgctatt aaagctaaaa tagctttcat ccaataattt ttgttttgct
    12241 tgtggagttt cagcaaatag agaacgaatt tcatcaaaaa tattgatata tgtagcaggt
    12301 gtagaacggc tagattttcc aataggtgct tggtccatta agataaaatc atcaatagca
    12361 tcaaatccag taaattcagt ataattttta tctgggatag atttttgttt caatttttct
    12421 tctagagcag gaagtaaact gtgaaataca agagagctct taccagaacc actaacacct
    12481 gtaatagagc acatacagtt taagggaatt tctacatcaa tattttttaa gttatttgca
    12541 tggcatcctt ttaagcttaa ccatttactt ggtataattt tattttgtga acttatttta
    12601 ttgtatgtac ttaaatattt acctgttata gagtttggat tttttataat ttcttgggtt
    12661 gtaccttctg cgataatgaa cccccctttt gtaccagcac ttgggcctac atcaataata
    12721 taatcagcag acagtattgt atctttatcg tgttccacaa ctataacagt attaccctta
    12781 tctcttagct cttctatcat tttgatgatt aaattatggt ctcttgggtg taaaccaata
    12841 gatggttcat ctaaaatgta ggttaagcct actaattcac ttcctagctg acttgataat
    12901 cgtactctct gcagttctcc tccagataaa gttggagctg ttctatctgt tgatatatag
    12961 ctaagaccta cctttaatag ataactaact cgaattttta attctgttaa gatatcattt
    13021 accaaagaga gctcattttt ttgaaggtga tttggtaatt cacacaacca attccataac
    13081 tgttctatcg tcatttttgt tagttcaggg aagcgataac ctttgattgt agtgaatcta
    13141 gcctcaatgc acagcaattc gccaccacat gtattgcaag gaattttgtt catatattga
    13201 tgcaaggtat tattttcaga actagattct ctaaaaagtc tttgaatgtg gttgattgct
    13261 cctgaagcag gtcttctaat ctttgattct cgtccctttg attcaaagct aaattcatat
    13321 atcttatcgt ctgtaccata taagattgca tctataaaat ctcttggtaa ttcattccaa
    13381 ggtatatcta ggtctatatt tttatctttt gctattgcat ataattcacc taccatccaa
    13441 ttaccatttg gctttttccc cctcaatttt ccaaaatagt aagtagctcc atctaatatt
    13501 gaaatagttg ggtcttttac aattaattga ggattaactt gataggtaaa acctaatcca
    13561 ttacaatcgt gacaagctcc agtatgggag ttagcattga aggttgaagt atttatctta
    13621 gaaaaaatag tttgacaatg tggacaataa ttttttgtat tattcttttt ttctaatgga
    13681 attttgcaat atggacagta actttttccg attgatacaa ataacattct taaataatcc
    13741 caaatgcttg taagagtacc aacagtagag cgaggatttt ggcttccttt tttctgttcg
    13801 atggctatag taggggttaa tccctgaagt aaatcaaatt ccggtttttg aagctgttct
    13861 gaaagttttg ctccgttact tagattttca aaataacgtc tttttccttc ttcataaatc
    13921 gtatcgaaag ctaaagaaga ttttccacta ccacttacac ctgtaataac agttatttga
    13981 ttttttggaa ttgtaacttc aacatccttt aaattgtttt gccttcctcc ttttaaatag
    14041 atagagcttt tattatgaca aagtgaattt ttaattgatt tatttattgc ttttgtaaat
    14101 ttgaatttct tttctagttc aagaggattg cctaattctt ttatttccga aatacctaat
    14161 atttttaact gagaaaagat tgatttcaaa taatcttcag gcaatttttc tattaacaaa
    14221 ttaagggctt ctatttttat atttccgctt gataatatct ctgccatttc atctaataaa
    14281 tttttttctg ctcttgttaa ttgattgtat tttttggaac ttaattctgt ccataaatcc
    14341 catggaagca attctaaacc aatcatatta ttaaagtcat gtagaagatt accctttaca
    14401 gaatgccaac ctttccaatt tttattatat ccaaagtcat ctggatgagc atgtccttgc
    14461 cgacatctta tccaggcttc tgaaccagtt aaaaaaccat ctgtttttcc gacatcatga
    14521 gtgtcaaaat taatttgaaa ataatttttt tgtatgtcat ctatttgtgc atctattctt
    14581 atccatctct ttgttagagt atcatagtat tctacaagcc agtggtcttc ataagtaagc
    14641 tcactttcaa aataattagc aaaacctgct ctcattctag cctcaaaacc tcgatatctt
    14701 aggagcgata caagaagtaa agaataatct ctgcacattc caacaagcct ttgttttggg
    14761 tttcttggaa tagttagtgg gttagaattt atttcaaata ttctttttaa catttgagga
    14821 attgtacgaa gcaattcctc atcagattgt tgcttattaa aggatatacc atataatttt
    14881 ccttggtctc catgaattac taggctttga accactttta ataactcaat tggagtcttt
    14941 ggtaaatctt gatatttatt ttcaaatttt ttaggatttg tgatgatact ttgattttta
    15001 tagttattta ttttcattta tatttcacct ctctaaatgg atgatatacc ctgacatggt
    15061 gtcatatgca aggacaattt agatttttgg ccaaaattta aaaaataaat aaaaaatgat
    15121 acagtgataa attgtaatac aaatatagtt tcaaattgca tataatataa ttatttaata
    15181 aaaccattat ctattgaatg ttaatgaaat gttaagatgg cattcttgaa tattaagaaa
    15241 tagaatacta taatatagtg tgaaggattt ttagtaaaaa aatttgtaag tgttaatata
    15301 cattaaaaaa taggtttata atttggagga aaaaaatgaa attatcaagg tataagaaaa
    15361 atagtttagt tctgtctata attttatgtt cacttattat ttcaatcctt gtaattactg
    15421 tttttaatac cgtaaaacta cacaatatat ctaataaaca atctaaaaac tatttaaatg
    15481 atgtatctac acagattgta atgaatgttg attctaaaat caaatttatt ttatccgact
    15541 taagaataat ggcagatttt attaagcaat atgaaggtga tagtcgatat gagtatttat
    15601 ctaaaagaaa gactagttat aagtattatg atgttggaat aatagattta gaaggtaaag
    15661 ctgagttttt aagtggaaaa aagtttgact taaagaatac tgtttcctat aaaaaaggaa
    15721 ttgaaggtaa agaatactca gaagtaatag agtcaatggg ttttgttctt tatagtgtac
    15781 ctatatttaa tgataatcat gaagtatcta gtattttaat aggtgtatcc aataaagaaa
    15841 gtatgaatga gattcttaat atagataact ttaatggaaa aggaactatt gaaattatta
    15901 atagtaaggg aaaacctctt ttcataggaa aaaatactga attaataaag gaccttagcc
    15961 ataaatataa gagttctgga gatgaacctt gggcacaaaa gatgcttgag gattttaaaa
    16021 atgataaatc agggaatatt acaataacct catcaaaagg tgtacaatgc ttattaactt
    16081 atcatccaat tacaagaggt ttaaatgatt ggcattttct tctcatagta cctgaagatg
    16141 ctgtacttgg tgaacttaat aaattaaact cttttacaat aacaatgaca tttataatta
    16201 catgtattat tggaattata acattaattt tatatattat aagaagaaaa tatgtaaatc
    16261 aaatagaaaa tattgcatat ttagatagta taacaaatgg tataaattca actaagttta
    16321 gtatgctagt caaaccttta atttcagaat cacctgatag tacttatatg atgatagcaa
    16381 tgaatataaa agattttaag ctaataaatg attgtttcgg tagtgaaaag ggaaatatga
    16441 cactaaaaca tctttacaat attttgtata aaaacattga tgaaaatgaa gaatttgtgt
    16501 gccgtcatga tgcagacctt ttctatttgc ttattaagaa tagaccagtg ttagaagccc
    16561 tggagttatt atataaaata gaagctgaca caaattattt taataaaaat agggaaaatc
    16621 catacttttt aagactatca gtaggtattt acacaattga aaatcataat gaagatttaa
    16681 ttacaataca agaccatgca aatacagcaa gaaaaagctt taataaaact catcaaagtg
    16741 atttttcttt ttatagtgat atagaaagaa aacgattaat atctgaaaag gaaatttcaa
    16801 atttaatgga aaaagccctt gaaaataaag aattttttat gtgcttacaa cctaaaattg
    16861 atataaaaag tggaaaaatt agtggagcag agtctcttgt gcgttggaaa aattcagaaa
    16921 agggcataat ttatccaagt gattttattc ctcttttcga aaaaagtgga tttatatgta
    16981 agttagattt atatatacta gaagaaacat gcaaattgat ttctaagtgg ataaaagaag
    17041 gtaaagaagt gttgagaatt tctgttaatg tatcacgtca acatctgaat gataaattgt
    17101 ttttagaaaa atataagcat atatgcaata aatacaatgt accaacatgt ctgatagatt
    17161 tagaacttac cgaatctatt ttcttagaaa atccagaagc tatagatata atagaggata
    17221 ttcattctaa tggatttaaa tgttctatag acgattttgg atttgggtac tcatcattag
    17281 gaatattaaa ggattttaaa gttgacataa ttaagttaga ccgttcattc tttgttagca
    17341 aaaataatat agaccgtggt aaggtagtta ttaagtctat tattgaactt agcaaaaggc
    17401 taggtatgaa agtaactgct gaaggaattg aagaattaga acaagttgag tttctaaaaa
    17461 atgtgggatg tgattatatt caaggttatg ttttttcaaa accattatta atttctgatt
    17521 ttgaaaattt tgcatatgaa aataataaaa ttaaaaatat ccattattaa atgtacaaga
    17581 taaaaaattt aggcaagtta tataattaaa aatataactt gtctttttta tttatatatt
    17641 taataaaaat atatttgcag attttgtaaa aataattttc aaatgttgta agttgtggct
    17701 aaagctttat tgtattattc tgaatataga aagatagtta ctgtcttaga taaaaactga
    17761 aacatacata ataatataaa atttgctata ttaataactc taattatttt ggaaggaggg
    17821 aaaatatgat aagtgggaga atgttactca tcatgaattt tctaaaagga aaaaataaga
    17881 caagttacaa ggatattagc aaacaactta gtatagaaga aagaaaagtt agatatgata
    17941 taaataattt aaatattgtt ttgcgttcat taaacaagtc agtaatacaa aagatgaaca
    18001 aaggtgtgtt aattattcct gatgacttcc aagtagtatg tataaataat aacgaatatg
    18061 tattttcctt aactgagcga gtatctatta tgaaaattat atcaatgttt aaaatagata
    18121 atctaaactt agaaaaatta agtaaagaat ttcaggtttc tagaagttca attaaaaatg
    18181 accttaatgt tttgtcaagt gaattagaaa gaaaccaaat aactattact tatgataaat
    18241 cttttaaaat aagtggagaa gaagacatta tatataagca aagattgaac atattaaaat
    18301 cgtattctta tctttttggt aaggaaaaat ctgatttaag tgtatttgag aagtatttag
    18361 tgaatgtaat tgaaaaaata ttcaaaggga tttatttgat tgatatatat aattggtcta
    18421 tgaatttatt attgcaaatg ggatggactt taaatgatga atcttttaca tggtatgtgt
    18481 caaacatttt cctttttaca tggtatatac attcagatga aaaacatcct ttagaatctg
    18541 cttcattaag tgagccgtgt tttgaaaata agtttgacca agaatttgaa acaattattc
    18601 aaaaaaagtt gactaaggaa caaatttttc tgttaaagag ttttgtattt tttacaaata
    18661 aatatgcaag tttaaacgag gatatggatt tgattagtac agaaattata gttcaagatc
    18721 taatttacaa tatgtcagaa atattagaga ttagctttaa agaagatatg attctttata
    18781 aaggattact caatcatatt gccccattga tagagagaat caaacagaat atacagattt
    18841 atgaggaatt acttcatgta ataccagata aatatcaata tgtacttgaa gctactaagg
    18901 tttctattca aaaaaacaga gttttaagtc aaataaagaa tgaaaatgaa acaatacttt
    18961 tggcaataca tttcttagga agtatacata gaaatgagag gaataactac aaaaatatat
    19021 tgttagtttg tggatttgga tatggtgtaa ttgctatgtt aaaggatagt ttagtaaatg
    19081 attaccagat aaatatagta gagagtattc catcatataa gttacaagat tataaagaat
    19141 gggaaagtat tgacttcatt ataacaacat caaagatagt aatagacttg cctaaaacaa
    19201 ttattgagat aaatccattt ttacaagaag aggattattt gaagtttgaa gaaaaaggga
    19261 taaaaagaaa gaacgtctta actaattata tgtcaataaa aaaaaggttg gactttttag
    19321 aagaagatgc ccaaaaaaga gtattaagta ttatatgtca agaacttgga tacagtgatg
    19381 agagaatatt atttagacaa cttaatttaa gtgatttaat aggaattgat accataagga
    19441 taattgatgg agatatgaaa tgggaagatg ctgtaaaaat tagttcaaac atacttgcta
    19501 attgtgattt tgtatcagca caatatgctg agaatattat agatatttta aaaaatgtgg
    19561 gtttttatgc tgtaaaagat aacgaatttg ctttactaca tggcaatgat agttcattag
    19621 tcaaagtaag ttcgataagt ttattaatat gtaaagaagc agttagtttt ggagataaaa
    19681 aggttaaaat catattttgc ctagcaagca gagataaaaa agagcaaatt cctgcaataa
    19741 ttaatctaac taaaatggtt tataagacta attttattgc tatgttagaa agtgcaaaga
    19801 caaaagaaga agcagaagtt ttaattcata aatatgagaa ggaggtcact gtatgaataa
    19861 attagttaat gtaaaatgtt catttaaaat acatgttaat tcaaaagaag aagccattat
    19921 atcgttagtt gatgtagtgt caaaagaagg atatttaata gataaaaatc aatttttaaa
    19981 agatgtttta aagagagaag aaacattgtc gacttatatt ggacatggta taggtcttcc
    20041 tcatagtcaa agtgtaggtg ttaaaaactc ttgtattaca ataggaaagc ttgatactcc
    20101 tattgaatgg acagaagaag gagaaaaagt ggatttaata tttttgatat cagtaacaaa
    20161 agacaatgaa aataatcttc atttaaagat tttatcaaaa ttagcacgtt tattgatgca
    20221 tgaaagtttt agaaatcaaa ttagatgttc agatgaacaa actgtttata atcttataaa
    20281 agaaaaaata gaggaggaag attaaaatga gaattttaaa gtttttgcaa aaacatctta
    20341 tgacagcaac atcttatatg attccatttg tggttgcagg aggaatatta tttgctttat
    20401 cagtaacttt aagtggacaa gctgctgttc ctgaaacagg ctggttggct aaactgaatc
    20461 aaattggagc tgctggcttg gctttattca ttcctatatt aggtggatat atagcattta
    20521 gtatggcaga taaaccagga ttagctccag gtatgatagg tgcatattta gcaaaagaag
    20581 taaatgcagg ttttataggt ggtatcatag caggatttat agcaggattt gttgttttac
    20641 aattaaagaa aattaaatta gctcctacaa tgagaacttt aggttctata tttatttatc
    20701 ctttagttgg tacattgatt acaggtggta taattgtatt tttaattgga gaacctatag
    20761 cttcttttat gacatggatg acaaactggt taaatggaat gtctggtgtt tctaaaattc
    20821 ctttaggtgg aatcttagga ggaatgatag cctcagatat gggtggccct ataaataagg
    20881 ttgctgctac ttttgcccaa actcaagttg acacacttcc atatttaatg ggtggagttg
    20941 gcgttgcaat ttgtatacct ccaattggtt taggattagc tacattattg tttccaaaaa
    21001 aatttagcaa ggaagaaaga gattcaggta aagcttcact attaatggga tgtgttggaa
    21061 ttacagaagg agctattcca tttgcaacat cagatccagt tagagtaata ccttgtatta
    21121 tggctgggtc gattgtagga aatattatgg cttttttatt aggatgttta aatcatgcac
    21181 cctggggagg tctgatagtg ttacctgtag ttgacaatag gttggggtat attgcatcag
    21241 tattaactgg agcagtagtt gttgcggtat taatgaaatt agtaaaaaaa gacgtgaaag
    21301 aagatgaaga aattgaagaa gatttagatg aatcaattga attaatattt gaagaattat
    21361 aaatataaat ggaaggaatt tgtataaaaa agtaaatata aaactataaa tttaaaggag
    21421 ataagaatat gaaaattgta gcagtaacat cttgtcctag tggagtagca catacttaca
    21481 tgtcggctga atcacttgaa ttatcagcca aaaaatttgg tatagaaata aaggttgaga
    21541 ctcaaggaag ctctggaata gataatgaat tgtcacttaa agatattgat gaagcaactt
    21601 gtgtaatatt gactaatgat gttgagatta gaaatatgga acgttttaaa ggaaagaagg
    21661 tagtaagaat gagtgtatct gagataatta agaaatctga tgcattaatt aagaaaataa
    21721 aagatacttt tcaataaaaa ttgatttatt ttacatataa ctcaaagatg tttttaaaga
    21781 aatttttatt aaaagcatct ttgaaaatat cttaaaaata gaataaaagg agatatagtc
    21841 atgaaaaagt taccaataaa gactgtcgtg caaagattac taaacttaca agaagagggg
    21901 aaaagtgcaa ctcttttagg aattggtcct atgtcaccaa acttgttaca agcaagtttt
    21961 gaactagcaa aagatgatga ttttccttta atgtttatcg caagtagaaa tcaagtagat
    22021 gcagatgaac taggtggcgg ttatgtaaat ggttggaatc aggaaacttt tacaaaagat
    22081 attaagaagg ttgccgacaa agttggattt gatggtttat attatttatg tagagaccat
    22141 ggtgggccat ggcaaagaga taaagagaga aatgaccatt tgcctgttga tgaagcaatg
    22201 gagttaggaa aaaaatctta tttagcggac attgaagcag gttttgacct attgatgatt
    22261 gaccctacaa aagacccatt tgaaattgga aaagtaattc cactagatgt agtactagaa
    22321 agaactgtag aattaattga gtattgtgaa aacgagagaa aaagacttaa tctaccagac
    22381 ataggttatg aggttggtac agaggaaacc aatggaggtc tgacttcaac tgagacgtat
    22441 gaaacattta taactagact aaaggttgaa ctcgataata gaggtttgcc aatgccaaca
    22501 tttatagttg gtcaaactgg tactttaact agaaagacag aacaagtagg aacttttaat
    22561 tttagaaatg cttatgattt agctcaaatg gctaagaaat atggagttgg tttaaaagag
    22621 cataatggcg attacttaga tgatgtaact ttattagaac atataccatc tcaaattatt
    22681 gctacaaatg tagctcctca atatggtact gaagaaacta gggcatattt aaaattagca
    22741 gaagttgagt gtaaattaga aaaagagggc ttagttgaga aaacttctaa tatcagacat
    22801 gttcttcttg ttaatgcaat tgaatgtgga cgttggagaa aatgggtagt aggagaacaa
    22861 aaaaatctaa ctactgaaga gatatttaag gatgaagttt tatctaatga aatactagat
    22921 attgcaggac attatacatt taataatgat gatgttaaaa aagaaataga agtgctttat
    22981 gataatttaa gtaagaataa tattgatggt caaagatttg ttgtagacca tattaaacgt
    23041 cctttgcgtg attatgcaga atgctataac ttaaaaggtg ttactacgag gattttaaat
    23101 aaataatagg acttatagtg gtgagtattg ttatactagg tatttatagt tataattata
    23161 cttaccacta ttaaatttag gaggactaat attttgatta atttaatttt tgatgtagat
    23221 gatactttat ataatcaatt aacgcctttt tacactgcat ataataaagt gttttcttca
    23281 ataaaggata tttctattga agatttatat atgagtagta gaaagtatag tgatgaggta
    23341 tttcatatga ctgaaaatgg agaaatgcca atcaaagaaa tgcatattta taggataatg
    23401 aaagcttttg aggagttggg aaattctatt acagaaaaag atgcacaaag ttttcaagat
    23461 gagtatatat atcaacaatc acaaattaca ctaataccag aagttgagag gattttaaat
    23521 ttttctaaag aaagaaatat taatctagga attataacta atggcccatc aaaccatcaa
    23581 agaatgaagt taaagcagtt aaatattgaa aactgggttg ataaaagtaa tatttttatt
    23641 tctagtgagg ttggattttc taagccagat actaatattt ttagagtagc tgagaatgtt
    23701 atgaatttag atagagaaaa tacatattat gtgggtgatt cttatagaaa tgatgtatta
    23761 ggtgctaaaa aagctggttg gaagagtata tggttgaacc ataggggaca tgagttagaa
    23821 gagttgtttt ataaacctga ttttgtaatt ttggaacata aggatttgat atctttattt
    23881 ataaaaatat gtagttataa aaatatgtag taaaaaaatg ttaataatag aattgtataa
    23941 aataattaat aataactata taaaattata tgtttagatt gtgagcaatc tattttatgt
    24001 taaaaataga ttatttagaa gaaggggaaa tcttaaaaaa atttgaatat ccccttttta
    24061 ttatttaatt aaaatgaaat agttagaaat atattttatt tagtttagtc aataacattt
    24121 tgggattctt tataactaca tgttaactgt tgaataggtt tatcatatgg tttaacccat
    24181 cctttattaa tacttaattc tgtaagtgct gtgtgacctt ctaccatttg agttaatgaa
    24241 gctgaatata tagctcttag ttcaggtgta ctacttgtca atgcagaatt aagatacata
    24301 ttggcagatg ctttagcaga tgaaagcata cttaacatta ttactttatc gtctatataa
    24361 gtattgttct taattagatt ttctatcata tttctcatgt tatctatacc tcctcagaaa
    24421 ttagtatttc attttcaact ataaattgtt gtatagcttt aattcttcct tctgttgcta
    24481 atatactaga ttctgattgt ctttttagat cttcatctga tattaacata tttattgctc
    24541 tttgcataag taatccgtca gactccattt ttataattgc tgctaaagat attttttcag
    24601 tttctgaaag tattctcatt taatcatctc ctatattgta atttatgctt taatagtatg
    24661 tctttctttt caaggaaata accattacac ttttttacag tattttatat tctcgttata
    24721 tcaaaattta gtcgacttaa tatattaata taattttgta ggatatttat cattaaatat
    24781 ctataaaata aattgtttga atattcataa agcaaaattt atttgtatgt acttcttcaa
    24841 gagtaaatat gagttttttc aaaaaattaa tttttatgat aattattaag ggctatattt
    24901 ttcttaaagt tgtgattatc attattaatt tacaataaaa ttgccgaaaa gccctctcct
    24961 ttaggtgtag ggatgaaagg taaggtctta atataaaaaa gttagaataa tgcttgtaat
    25021 ctaataccgc tattgatacc ctatatttag gaggtgttag tttttatgta taaatctaac
    25081 aaaaatatag tttatgattg caaatatcat attgtatttt gccctaagta tcgtaaacct
    25141 gttttagttg gcgaagttga aaagatgtta aaagaaatac taccatataa agcagatgaa
    25201 cttggagcag aaataataga aatggaaact gataaagaac atgtgcactt attaatatct
    25261 tgtgaccctc aatatggaat tcataaagta gtaaaaggtt taaaaggctt tagttcgaga
    25321 gtattaagag agaactttcc acatttaaag tctagtatgc ctagcatgtg gactaatagc
    25381 tattttgtag gtactgttgg ttctgtgagt ttagaagtag ttaaacaata tatagaaaat
    25441 caacaagtta ggacaaagaa atgataaaaa ctcatagagt gaaattaaac ctaactagaa
    25501 cacaatttga
//
LOCUS       DAEHWM010000053        25224 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.054, whole genome shotgun sequence.
ACCESSION   DAEHWM010000053 DAEHWM010000000
VERSION     DAEHWM010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25224
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.054"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(796..1113)
                     /locus_tag="KNP36_002232"
     CDS             complement(796..1113)
                     /locus_tag="KNP36_002232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874099.1"
                     /translation="MNFRNIYLILMGLGIIILTTIISLIEIKIGFCNEKYFNKLESKY
                     GNIDRKRTIKLEVLYRYVTGFEYIAIGLFTKRLDITIIAIILVATITVILYYLVRKRY
                     ITI"
     gene            complement(1423..1779)
                     /locus_tag="KNP36_002233"
                     /pseudo
     CDS             complement(1423..1779)
                     /locus_tag="KNP36_002233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889008.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            2172..2561
                     /locus_tag="KNP36_002234"
     CDS             2172..2561
                     /locus_tag="KNP36_002234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0874100.1"
                     /translation="MKINKLPHAELKLMKYIWGVDDVLASRDIIEDMKLKYDWKKSTT
                     LTFLKNLVDKGFLTTDKVDRCTHYTIAIKEKDYLKVETKSFFSFMHNNSFKSFISALH
                     DDEVLDSKSLDKLEEYFKNLKEEDIDD"
     gene            2881..3390
                     /gene="vanZ1"
                     /locus_tag="KNP36_002235"
     CDS             2881..3390
                     /gene="vanZ1"
                     /locus_tag="KNP36_002235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycopeptide resistance protein VanZ1"
                     /protein_id="HBF0874101.1"
                     /translation="MKSRKHNITKGLFIVYIIILTWIILFKLQFDISSLETMNLRSIN
                     LIPFAGSLIINNRVDISEIILNVAIFVPFGIYVCMLKEEWSFIKKVIPIFITSLVFET
                     LQYIFALGASDITDLIGNTLGGIIGIAVFMLLSKIFKNNTIKIINVLALIVTIIVVLF
                     LGLVIFANL"
     gene            complement(3492..3686)
                     /locus_tag="KNP36_002236"
     CDS             complement(3492..3686)
                     /locus_tag="KNP36_002236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase"
                     /protein_id="HBF0874102.1"
                     /translation="MSVIVMCSRCGKEIDKYRNKYITYYEKNTNAEIKVCINCALDLL
                     EKTRENQELNIQEFQDTIIL"
     gene            complement(4202..4594)
                     /locus_tag="KNP36_002237"
     CDS             complement(4202..4594)
                     /locus_tag="KNP36_002237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0874103.1"
                     /translation="MAALKSFEKPLTPEEEIEYLTKFKIENDKSAKDTLIERNMRLVA
                     YIAKKYNNSTEDQDDLISIGTIGLIKAIETYNIDKGTRLATYASRCIENEILMNIRSN
                     KKNKTQVSLQDPIGTDKEGNEINTTLYM"
     gene            5161..5523
                     /locus_tag="KNP36_002238"
     CDS             5161..5523
                     /locus_tag="KNP36_002238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874104.1"
                     /translation="MKIRKSGFISIECIISIAILYVAVYLVSTSLYNCYSFISRNISD
                     REMLSTAKKYIEDEKYRIQNSKYELIEDKIEKNYINGYEINSKIEQILDYYQCYEINI
                     EIKNEFKKLRFNSYVTRK"
     gene            5507..6232
                     /locus_tag="KNP36_002239"
     CDS             5507..6232
                     /locus_tag="KNP36_002239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874105.1"
                     /translation="MLLENKGSILIITLIIFSIISTVCIMCIGLIYTHNNMFELGYKD
                     IQLKEISLSGIEISVSNVLSCVEEAIDVSNNEDEFREYFLGNNMIECIKKIKDTSYSS
                     LEELSLKVENNTIYDRGDFFEFDIESNVREKEFLKAIKVRVKIKNPWIGIDIEDYMDK
                     SNNNKIDDKTFNNYKASENNEILNQFKNESENIRNQEVGGFTEEDEEDEEYEEELKQN
                     IIENIKKNFDEKNLVQVYKYRGV"
     gene            6252..6671
                     /locus_tag="KNP36_002240"
     CDS             6252..6671
                     /locus_tag="KNP36_002240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874106.1"
                     /translation="MTVIELIVSISIILLIVTLSFPKDNLENHKINLFARQLCSDIRY
                     VRRINMFSNYNTYIYYINQGKHEGYVLRKDGKNIKSIMLPKNAKIARSIEIIKFKSDG
                     SPQKASTIEIYNNRLRKTITITPVSGRVLLKEGKYET"
     gene            6661..7185
                     /locus_tag="KNP36_002241"
     CDS             6661..7185
                     /locus_tag="KNP36_002241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874107.1"
                     /translation="MKHKYGYLLLESVVSLSSMVIIILVLYSIFLSTINLKLKVEDKI
                     ELQQQSLEIIKSMEGIISNSMGIMNVSNYEETFKKTTSIKCRYLDENNNEEGISNKEI
                     ILNERRNKLFVNSLNGESSQAGGYEIGDYVDEMYVSITNNGQYVNIKLKLSKRSQKYE
                     TDFKIKVWNFSESI"
     gene            7497..8054
                     /gene="efp"
                     /locus_tag="KNP36_002242"
     CDS             7497..8054
                     /gene="efp"
                     /locus_tag="KNP36_002242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HBF0874108.1"
                     /translation="MVSAGDFRKGVTFEKDGQPCLVVDFQHVKPGKGAAFVRTKYKNL
                     KTGAIREESFNPSEKFPKAVIDTRQMQYLYNDGELYYFMDQENFEQIPLNYEQVEDAI
                     KFLKENEVATIRFYQGQPFQVEAPNFAELEVTDTEPGIKGDTASNVTKAATVETGAVV
                     QVPLFINTGDKVKIDTRTGEYLSRV"
     gene            8146..8601
                     /locus_tag="KNP36_002243"
     CDS             8146..8601
                     /locus_tag="KNP36_002243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0874109.1"
                     /translation="MKHLYEEVAYLKGLAEGLEISAESKEGKMIHKIVDALEVFADAI
                     VTLDEEQEELQDFVESIDEDLADLEEDIADMEEDLYEEDDDEDDEDFSYIEMECPNCG
                     ELVEIDEDLLYDDEVDVVCPDCKAVILSSEDDCDDDCTCGGCSSCDDRE"
     gene            8764..9474
                     /locus_tag="KNP36_002244"
     CDS             8764..9474
                     /locus_tag="KNP36_002244"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HBF0874110.1"
                     /translation="MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKY
                     NFNERLEFLGDSVLGIVISDYLFNEEANLPEGELTKLRANIVCEDSLSEVANDINLGI
                     HMLLGRGEEATGGRHRTSILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKG
                     NIFRDYKTHLQEVLQGNGENNIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKK
                     EAEQLAAKIALKKKLWEK"
     gene            9528..10598
                     /locus_tag="KNP36_002245"
     CDS             9528..10598
                     /locus_tag="KNP36_002245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0874111.1"
                     /translation="MKKRIIPIFVPHKGCPHDCIFCNQKKITGVSTDVTSEDARNIIE
                     ECLETIDKDADVEIAFFGGSFTAIDIDIQKSLLSVAKEYVEKGLVKDIRMSTRPDCID
                     EDILSMLKEYKTSIIELGVQSLDEKVLLDSIRGHQSEIVYKSSKMIKNSGIKLGLQMM
                     IGLPADTEEKCIFTAKKFVELKPDCVRVYPTLVVKDTGLEKLMEQNKYNPFTLEESVN
                     IVKKVLVLFYVNNINVIRVGLQATDDIQIGKAVLAGPYHPAFRELVEADMIKDYLEFV
                     ILQNKNIKQMLVKSNKKNISKIIGNKKTNVKYMEEKFGVLLKTQESDLDINQLEIVLD
                     GKSLISANMRDIHRKLYDIYDL"
     gene            10626..14180
                     /gene="smc"
                     /locus_tag="KNP36_002246"
     CDS             10626..14180
                     /gene="smc"
                     /locus_tag="KNP36_002246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HBF0874112.1"
                     /translation="MYLKRLELKGFKSFPVKTDIIFKEGITAIVGPNGSGKSNISDAV
                     RWVLGEQSIKSLRGDKLEDVIFAGTDTKKPMNYCEVALTIDNSENQLELDFTEVTIRR
                     RAYRNGESEFFLNNKSCRLKDIKEVFLDTGIGKDGYSIIEQGKVDEILSNNPLSRRKV
                     FDEACGISKYRYKKQEAERNLSNTKENLERIDDVYIEIENQLKPLFNQQTKAKKYLEI
                     SEKLKTLEVNSFIREIEGIEKELSEVNEHRKVIEKELNEKEEQKNVVEKKQEDINKEV
                     EVLQDVIEKSVDYINSIKGVISKKESQINLIKERIRNFTNEISRKNLEIKDIKEKLNE
                     NKQYIKELESNKLSGSEELSTLQENIKVLEGSKDKQKIKLESLNNEIELLKESIIDIL
                     NKKQEFSNKLSTLNANKENMNIRDENINSEITELNKNIEIKSSELDTINKEFNMQNEN
                     LKNVNNRHKELSINLQDSISEHNKLEDEIQKSKYNLNGYNSKLNVYIDMENHYEGFNR
                     GVKEVLKNKNLKGVHGALGQIINVPEKYEKSIEAALGAYMQNIITDNEFSAKFAINYL
                     KQNNLGRVTFLPLNIIKSNKISLGNLKANTKFIGIASDLITFDEKYRNIIENILGRTI
                     LINNIDEGIKFAKETGHRFKIVTLDGEILNPGGSLTGGSLKTNGNILSRKRYINEYTE
                     KISNIKNEISHLELKRESLDKDVKNIKNEIDSHESKIKDLEKSIIIKSTSIKNVESEI
                     ESLKGSITKLENEKNDLNSNLNYTLEKSDDVRKDMEELDDLYNKNKEKIDALNEEIKR
                     YNDLYDKEKSEFDELNLSLVKKTEVYNSIVRDIKRISGENCELEEKNKQLEESLNYEE
                     HEIIKLQDSILTEEKEKENLTKQLGDSNRNLETRKIAKDDLKNSFDEINKELKTIDRQ
                     HIELKESLFKVGGRLERLKTSQDTYINKLFEQYDMTLVQALEIKDEDLDIDRKFLESL
                     KREIRSLGNINIDSIKEYEEIKERYDFYSEQKQDLEESMEEIEKLIHTLEENMKSEFE
                     IKFEEISKNFKYVYKRLFGGGCGELTILDKENLLESDILITAQPPGKKMKNLNLLSGG
                     EKALTAISILFAILITKPTPFCILDEIEAPLDDANIFRFGEFLKDLSKETQFISVTHR
                     RGTMEAADYIYGVTMQEKAISKVISLKLKEAQEITDII"
     gene            14207..15487
                     /gene="ftsY"
                     /locus_tag="KNP36_002247"
     CDS             14207..15487
                     /gene="ftsY"
                     /locus_tag="KNP36_002247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HBF0874113.1"
                     /translation="MLKKLFGFGKDKEKEIEKKDAEEEIEVEDSVDNLENLEETIFSG
                     LEEEVIDKVEDIEEKNEESVNNEGTEEIENFEKIEVEMDSNGKEVENISNNDSQEEII
                     EELENYDEIESKEIEDKEDKKVNLFERLKQGLTKAKQGITDRIDEVLKSYTKIDEELL
                     EDLEEILITADVGVNTTMDIIERLRDKIKQKGITEPIKVREELKSIVEDILTNENSTL
                     DIEPAPCIILMVGVNGVGKTTTIGKLANRYKKDGKKVLLAAADTFRAAATEQLEIWAN
                     RTNVDIIKHQEGADPGAVVFDAIKAAKARKTDVLICDTAGRLHNKANLMNELGKVFKI
                     VDREFPEAKREVLLVVDATTGQNAVVQAKTFKEVADITGIVLTKLDGTAKGGVVLAVK
                     SEVDVPVKLIGVGESVEDLQDFNAKSFSDALFGN"
     gene            15590..15958
                     /locus_tag="KNP36_002248"
     CDS             15590..15958
                     /locus_tag="KNP36_002248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HBF0874114.1"
                     /translation="MNIEKMVEIGLLFEQYKELLTDKQKEIVALYYEEDYSLGEISEN
                     LNVSRQGVYDTLKRSEKILRDYEEKLHLVSKIQEQEKNIKIIKDKIIDIKEDLLHNRD
                     CANLIPKLENIEDVCREMIK"
     gene            15955..17307
                     /gene="ffh"
                     /locus_tag="KNP36_002249"
     CDS             15955..17307
                     /gene="ffh"
                     /locus_tag="KNP36_002249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HBF0874115.1"
                     /translation="MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADV
                     NFKVVKDFIKKVQERCVGQEVMQSLTPAQHVIKIVNEELTSLMGDVQSKVMISSKPPT
                     ILMMVGLQGAGKTTTAGKLGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVF
                     NMGDKENPINIAKAGLSHAIKNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEIL
                     LVVDSMTGQDAVNVAESFNEALGVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMG
                     EKLDDIEPFHPDRMASRILGMGDVLSLIEKAQENIDLEKAKELEQKIKKQELDFEDFL
                     QQMEQIQNMGPLDKILGMIPGMGNVKDQLGDVDLNGKEMKRTKAIIQSMTTYERRNPG
                     VLNASRKKRIAKGSGTSVQDVNRLIKQLNEMKKMMKMFAGSQKSMKKRGGLGGLPFFK
                     "
     gene            17345..17617
                     /gene="rpsP"
                     /locus_tag="KNP36_002250"
     CDS             17345..17617
                     /gene="rpsP"
                     /locus_tag="KNP36_002250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HBF0874116.1"
                     /translation="MAVKIRLKRMGANKKPFYRIVVADSRAPRDGKFIEEIGYYNPIS
                     EPKQVRINDEKAIKWLATGAQPTEVVKKLLVKNGVIEKFEASKQAK"
     gene            17682..17909
                     /locus_tag="KNP36_002251"
     CDS             17682..17909
                     /locus_tag="KNP36_002251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HBF0874117.1"
                     /translation="MKELVVDIAKALVDNPDSVVVEEFEDNDGIVLKLTVAQEDMGKV
                     IGKQGRIAKAIRTVVRSVANRENIKVSLEIV"
     gene            18017..18532
                     /gene="rimM"
                     /locus_tag="KNP36_002252"
     CDS             18017..18532
                     /gene="rimM"
                     /locus_tag="KNP36_002252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438220.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA processing protein RimM"
                     /protein_id="HBF0874118.1"
                     /translation="MKEKLTHFKVGQIVNTQGLKGEVRVYPLTDDIERFDELKDFYLG
                     KDLNNKLAVEKVRYKGSMVIMKIKGIDSIEKAEKLKNKFMYVAREDSRELEEGEFFIA
                     DMIGMEVLTVDGKYVGILEDVLQYSANDVYVVKGEEDKEFMIPAIKKFVPTIDIDERK
                     MIIDPIKGMID"
     gene            18541..19236
                     /gene="trmD"
                     /locus_tag="KNP36_002253"
     CDS             18541..19236
                     /gene="trmD"
                     /locus_tag="KNP36_002253"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HBF0874119.1"
                     /translation="MRFHIMTLFPEIFNSYMDESIMKRAVEKGIIEVHIYNIRDFSNN
                     KHKKVDDYPFGGGAGMVMTPQPIYDTYKHIITTHNINNPSVIYLTPKGKVYNQSMAKQ
                     MSLKEDIILLCGHYEGIDERIIDLIVTDEISIGDYVLTGGELPALIMIDSISRLIPGV
                     LNQEESFEEESFKDNLLEYPHYTRPRDFEGLKVPEVLLSGNHKKIDEWRREESIRITK
                     ERRFDLYKKSNEK"
     gene            19421..19771
                     /gene="rplS"
                     /locus_tag="KNP36_002254"
     CDS             19421..19771
                     /gene="rplS"
                     /locus_tag="KNP36_002254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HBF0874120.1"
                     /translation="MNEMLRAIEQEQLKNEVPNFGPGDTVKVHVRIIEGKRERIQVFE
                     GVVLKRQGGGARETFTVRKMSFNVGVERTFPVHSPKIEKIEVTRKGKVRRAKLNYLRG
                     RVGKAAKIKEARNK"
     gene            20092..20988
                     /gene="ylqF"
                     /locus_tag="KNP36_002255"
     CDS             20092..20988
                     /gene="ylqF"
                     /locus_tag="KNP36_002255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HBF0874121.1"
                     /translation="MSNEYEEYLMNDNLHINWYPGHMKKTKELVKNNLKLIDVVIELL
                     DARIPFSSKNPDIDRLVGDKPRVVVLNKSDMADRDKLNQWIEYYKKINIKAIPVDTIK
                     GVGINKIIEECKNVTREKMSSLKDKGRKERAIRIMIVGVPNVGKSSLINKLTGRKSTQ
                     TGDKPGVTKGKQWVRLKGNLELLDTPGILWPKFEDQEVALNLAFSRAIKDEILDTETL
                     ALRLIEKLMKIEPEKLKARYKLDCLGETPIETMDMIGHKRGFITGKKELDYTRIATTV
                     LNEFRDGKIGNITLEVPENVKR"
     gene            21377..22669
                     /gene="brnQ"
                     /locus_tag="KNP36_002256"
     CDS             21377..22669
                     /gene="brnQ"
                     /locus_tag="KNP36_002256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBF0874122.1"
                     /translation="MGKTKDVIVFGFALFAMFFGAGNLIFPPYLGIITGPEWLIAFLG
                     FTFADAGLALLAVMATAKFDGNVVEMFKRCGMKLGILIGCADILCIGPFLAIPRTGAT
                     TYEMGIMPLFGTSIPVLLFCILFFAISYVLTIRPSKVVDIVGQFLTPALLIALAFIII
                     KGIISPLGDIVDKPMIPNVFAEGIGQGYQTMDAFAAIALASVLIVSLNDKGYSTISDK
                     LKMIGKAGVLACGGLALVYGGLCFLGATVSTMYGTDAVQSQVIVNITEGLLGNVGKAI
                     LAVVVSLACLTTSIGLTSATGQYFSRLTKGKLSYEKIVLAVSVFSAVVASFGVGTIIK
                     IASPILSIVYPPSIVLIILAFFNEKIKNDNVYKGAVYMSLFVSILTVISSYGVAVPVV
                     NSLPLNSLGFNWVVPVIIAGIIGNFIPSKSQSNTLGTN"
     gene            23788..25080
                     /gene="brnQ"
                     /locus_tag="KNP36_002257"
     CDS             23788..25080
                     /gene="brnQ"
                     /locus_tag="KNP36_002257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBF0874123.1"
                     /translation="MGEKQINFKDVIVIGFALFAMFFGAGNLIFPPYLGVLSGSSWLV
                     AFIGFLFADGGLALLAVIAATKFNGDTSKMFSRAGKGLSIALGCAMVICIGPLLAIPR
                     TAATTYEMGILPTIGSGISPVIFSIVFFALVLVLTIRPSKVVDIVGSILTPALLIALA
                     VLIVKGIVSPLGEIRDSSLIQNVFAEGITQGYQTMDALAASVFASIIIMSVIAKGYTG
                     EKEKMKATISAGVIAVIGMALVYGGLCYLGATVSQQYGQDVQQTALIVAITAALLGTT
                     GKILLAIIVALACLTTAIGLSSAAGQYFSTLTDGKLKYEHIVIVVCVFSAIISNFGVS
                     TIIQFSSPILSMVYPATITLVILALFSNKIKNDNVFKCAAYMALLVSVLTVATSFGVK
                     IPLVNSLPFASLGFNWIVPVVIAGIIGNFIPSKSSKTA"
BASE COUNT        10448 a         2438 c         4327 g         8011 t
ORIGIN      
        1 aatatttttg gaaattatat atattataac aattatagca aatttttagg gtataatttt
       61 taaaattata ttctactatc aaaagatatg aataaatgat tgtatatatt atatcaattt
      121 ttatatttca tagtccattt tttcatcaca ttttcgcttg tcaagaataa tatctttaag
      181 agtgaagcgt ttgatgtaaa tctggacttt gtttttgaga catttttgaa atatttatta
      241 aatctttcga ttatacttgt aatatatatt atagatatta cttattttag taaaactaaa
      301 ggatgatgct acaacattcc agttatttcc caaaatttta atttctgaag tatactgttt
      361 acattatttt taatctattt tatctaaagt cgataaggct tcttattcat taactgacct
      421 atatacagat ttaaaattac ttattaattc ttttgagtcc ttgtatgaaa catatttaaa
      481 gtatttctta tctaatgtat taaacatttt tgtattacag aatgaggata acttgtagct
      541 attgtctctt tgaaataagt catctgtgtt tactcctaaa actacttata tctgtagatt
      601 ttataagttc tccatcttat ataatttctt tgattaattg ttttcttaaa ttattcataa
      661 aaaaatctcc gttacaatat ttgattatat ttaaatcatt gctataaaga agacttttat
      721 taactttgaa aaacaaatta ttttaattgc tggtgattag ttgctacctt cttttgatat
      781 taattctatt agattttata tagttatata tctctttcta actaagtaat ataatattac
      841 tgttatagta gctactaata ttattgctat tattgtaata tctaatcttt ttgtaaataa
      901 tcctattgct atatattcaa aacctgttac atatcgataa agtacttcta gtttaatagt
      961 tctttttcta tctatatttc catattttga ttctaattta ttaaaatatt tttcattaca
     1021 aaaaccaatt ttaatttcaa ttaaagatat tattgtagtt aatattataa ttcccaatcc
     1081 cataagtata agataaatgt tcctaaaatt catagaagat acctccttta taatataatc
     1141 atcaactcat gttgtattaa ttttcctaat caaagtataa cagtaacaca agtataaaga
     1201 gtatctaaaa tattacaaat attaaatgag aaaaagatgg taagttaacc ccaccatctt
     1261 attttttatc tactaatgaa tgatgctaca aaagttagta taaaaaatga aacaaacaat
     1321 ataatgaact tgtgtaattt acttagttgg aatgctttat tacaaaataa taaaattaat
     1381 gctgaaacaa ttgcaaaaag tagatatttt ataatcattt tatcacctat tgatttctac
     1441 agattgtaag tagtatttgg ttacacaagc acctccttta ttataacgta ttttttaaat
     1501 ttaaagattt ttccagatgt tatatttgac tcaaggtaca ttgtaattaa tctaactata
     1561 agtggcaagt actgtcctat accaggaata gcaccagcca aaagtcctga aatccctata
     1621 ccagcatcag ttaaagttaa tgcaactcct ttagaaagat ataaattaaa acctattcta
     1681 gcccaaacta ttttatttat ttcagctttt ctataatata attcaagtag tgtcaatatc
     1741 gttcttctta aggtttttaa ttagcttata tattgttatt gtataatata attattaaaa
     1801 attaactata ttaaatatta ataaaaaata tagtaaaact taataataca tataataaaa
     1861 cttaatataa attaagtata tgaaataaat atcctgtatt taagcttata gattataatg
     1921 aaatataata catgttgcaa taataaaacg aactaaaatt atcacactaa agcataaaac
     1981 atactctaat catgttagat aaatttttga atatataatc caaaagtact ctctaaagta
     2041 gagtacttct tttttattaa ttatttttat atagaataaa ttggaattta tatttattcc
     2101 aatctaattg attacataca cttattgtta taaagtttag ttatacataa attggtaaga
     2161 ggtgtaaact aatgaagatt aataaattac cacatgcaga actaaaacta atgaagtata
     2221 tttggggagt agatgatgta ttagcctcaa gagatatcat agaagacatg aagttgaaat
     2281 acgattggaa aaagagcaca acattgacat ttttaaaaaa tttagtagat aagggctttt
     2341 taactactga taaggtagat agatgtacgc attatactat agctataaaa gagaaagatt
     2401 acttaaaagt tgagacaaag agttttttta gttttatgca taacaattca tttaagagtt
     2461 ttatttcagc actacatgat gatgaagttt tagatagtaa gagcttggac aaattagaag
     2521 aatactttaa aaatttgaaa gaagaagata ttgatgacta ataaagctat cagtatcttt
     2581 ttagtttgag acaattgaga gtagcgtttg gatttaatgt tagttttatg tgatggtaga
     2641 acattatata aagaaaagtg attatttcct tagtgtttga tagtaaaaaa tatagagaat
     2701 aataccaatt aaaatttaaa gatatatgaa atactacaat agcttaaatc atgtaaatat
     2761 gataaagata ttgaaattat aaaaggaata taattttaga agaaatagtt gacagataaa
     2821 ttaccttact atattattgt attaataaaa taatacaata atatagtaag gaggtaataa
     2881 atgaaatcta gaaaacataa tattacaaaa ggattattta tagtttacat aattatttta
     2941 acatggataa tactatttaa gttgcaattt gatatctcat ctcttgaaac catgaatctt
     3001 agaagcataa acttaatacc ttttgctggg tcacttataa ttaataatag agtagatata
     3061 tcagagatta tattaaatgt ggctatattt gtaccatttg ggatatatgt gtgtatgcta
     3121 aaagaagaat ggagctttat aaaaaaagtt atacctattt ttataactag tttggtattt
     3181 gaaacacttc aatatatatt tgcactaggt gcaagtgata taacggattt gataggaaac
     3241 acactaggag gaatcatagg aatagctgtt tttatgctat tatcgaaaat atttaagaat
     3301 aataccataa aaattatcaa tgtattggca ttgattgtga caattattgt tgtattattt
     3361 ttaggattag ttatttttgc aaacttatag aaataagtat atatgtttag cttaaaatag
     3421 aacgtaagat acagttacat ataaaattat ttacacataa aaagcaccta tacaggtgct
     3481 ttcctaaatt attaaagaat tattgtatct tgaaactctt gtatgttcaa ttcttgattt
     3541 tctcttgttt tttctaataa atctaacgca caatttatac aaactttaat ttctgcattg
     3601 gtatttttct cataataagt tatatattta tttctatatt tatctatttc ttttccacaa
     3661 cgactacaca ttacaattac gctcatatct tagttcctcc atctctaatt attcttaata
     3721 tattcaatag tatcactttt ctgaaaataa tgattgttaa aactgtatca aatttagatt
     3781 tactttttat tataatgcat tttaataaaa aaataaaggt tatgggtaaa atatttatag
     3841 aaaaaagtat attattgaat agattataaa attttattat tttttagcag tgttaaatac
     3901 acattaatat ctataaagtg acaaaataaa aaatactatt taaatagata ttaaaaaatt
     3961 gataccaagt atttatttgc tatatgaata acaatttatt taggaacttt actttaacac
     4021 tgtataataa taaagtaatt gctaaaaacg tttgatgatt tggatgtatt tttagaaatt
     4081 agaaaaatat atacttactg actaatgata atcttatatg tattttagtt tgagtgattt
     4141 aagaaaagtg ttttgaatgg ggattatttt atagagtaaa taaatatata atagtagaaa
     4201 attacatata aagagtagtg tttatttcat taccttcttt atctgttccg atagggtctt
     4261 gtagagatac ttgagtttta ttttttttgt tagatctaat attcattaaa atctcatttt
     4321 caatacatct agaagcatat gttgctaatc gagttccttt atctatgtta taagtttcta
     4381 tagctttaat taatcctatt gtacctatgg atattaaatc atcctgatct tccgttgaat
     4441 tattatattt ctttgctata taagctacta atctcatgtt tctttcaatt aatgtatctt
     4501 ttgcactttt atcgttttct attttaaatt tagttaaata ctcaatctct tcttcagggg
     4561 ttaagggttt ttcaaaagat ttaagagctg ccaataggtc accccctttt caacggtcac
     4621 tttaaattat atgaaggaga cttatccaag ttgactgtta tctaataaaa taatatgcat
     4681 atttttagaa tttaaaacat atatttgcaa acttttgaat ggaatatgac ataaagagtg
     4741 ggaatttaaa tttaagtttt tgttgtatat atatgaaata aggcgaagaa attattgatt
     4801 tataaagtat aaattggaat tgaggtgtca ataaatataa aaggaaatag tatttatata
     4861 tgttttggtg ttgaagtaaa agattaatgc aaagcattag agtctataaa aatatgaata
     4921 taggaggtgt aattttacaa tacttaaaaa agtaaatgta attaattgtt tgtataaagt
     4981 tgattacaag caaaagtatc agtcatagtt aatactgtta agggtgaagg tggtgtgtta
     5041 atttatatat gtatgggaag aaattttgat tacaatgaaa aaacttacaa aagatattta
     5101 tgaaaaaact tatagttaaa tgtttatata taaaatatta tttaggggtt gtttttatta
     5161 ttgaaaataa gaaagagtgg ttttatatca attgaatgta taataagtat tgctatatta
     5221 tatgtggctg tttatttagt ttctacatca ttgtataatt gttatagttt tatcagtaga
     5281 aatatatctg acagagaaat gttaagtaca gcaaaaaaat atatagaaga tgagaagtat
     5341 agaatacaaa atagtaagta tgagttaatt gaagataaga tagaaaaaaa ttacataaat
     5401 ggatatgaaa ttaacagtaa aatagagcaa attttagatt attatcaatg ctatgaaata
     5461 aatatagaga taaaaaatga atttaaaaaa ctgaggttta atagctatgt tactagaaaa
     5521 taaaggctct atattaataa taacattgat aatattttct attataagta ctgtgtgcat
     5581 tatgtgtata ggtttaattt atacacataa taatatgttt gagttaggat acaaggacat
     5641 tcaactaaaa gaaatttctt taagtggaat agaaatatca gtaagtaatg tactttcttg
     5701 tgttgaggaa gctattgatg tatctaataa tgaagacgaa tttagagaat atttcttagg
     5761 aaataatatg attgaatgta taaaaaaaat aaaagataca tcttatagta gtttagaaga
     5821 actttcttta aaagtagaaa ataatactat ttatgacaga ggagattttt ttgaatttga
     5881 tatagaaagt aatgttagag aaaaagaatt tttaaaagca ataaaagtaa gagtgaaaat
     5941 caaaaatcca tggataggaa ttgacattga agattatatg gataaatcta ataacaataa
     6001 aattgatgac aaaacattca ataattataa agcatctgaa aataatgaaa ttctaaatca
     6061 atttaaaaat gaaagtgaaa atataaggaa tcaagaggtt ggtggattta cagaagaaga
     6121 tgaagaagat gaagaatatg aagaagaact taaacaaaac ataattgaaa atataaagaa
     6181 gaattttgat gaaaaaaacc tagtacaggt atataagtat aggggtgtat aactttgaaa
     6241 aaagaaggaa tgtgactgta atagaattaa tagtatctat cagtataata ctcttgatag
     6301 ttacattatc ttttccaaaa gataatcttg aaaatcataa aataaattta tttgcacgtc
     6361 aactttgttc agatataagg tatgttaggc gaattaatat gtttagcaac tacaatacat
     6421 atatatatta tataaatcaa ggtaaacacg aaggttatgt attgagaaaa gatggtaaaa
     6481 acattaaatc aataatgcta cctaaaaatg caaaaatagc taggagtatt gaaataataa
     6541 agtttaaatc tgatgggtcg cctcaaaagg cgtctacaat agagatatat aataatagat
     6601 taagaaaaac tataacaata acacctgtaa gtggaagagt acttctgaaa gagggaaaat
     6661 atgaaacata aatatggtta cttgcttttg gaaagtgtcg tatcattgtc ttcaatggtg
     6721 ataattatac tagttttata ttctatattt ttgtctacaa taaacttaaa gttaaaagta
     6781 gaagataaga tagaactaca acaacaaagt cttgaaatca taaaatctat ggaaggaatt
     6841 attagcaatt ctatgggaat aatgaatgta tctaattatg aagaaacatt taaaaagaca
     6901 acatctataa aatgtagata tttagatgaa aataataatg aagaaggcat aagtaataaa
     6961 gaaattatat tgaatgaaag acgaaataag ttatttgtaa attctttaaa tggcgaaagt
     7021 agtcaagcag gtggttatga aattggagat tatgtagatg agatgtatgt atcaattact
     7081 aataatggtc aatatgttaa tattaaattg aaattatcaa aacgtagtca aaaatatgag
     7141 actgatttca aaataaaagt atggaatttt agtgaaagta tatagaaata cataaattta
     7201 agagaaagaa gtgacatcaa taagtcatat aaaatataat tattgagaac tatataacta
     7261 aataatatca atatgtaaag tgtatagatt aagaatatag aggataataa taaaaatata
     7321 gaataagtaa tttgccaaat acttgtttat attgtataac ttatgatatt atgatattag
     7381 taaaaatttg taatcctgac ttgacagaat tcaagtaaga gatataattt taaaggcata
     7441 gtaatgtaaa atttactaaa aaataagaaa tttattttaa tatggaggaa caaaaaatgg
     7501 tatcagcagg tgattttaga aaaggtgtta catttgaaaa agatggacaa ccatgtttag
     7561 tagttgattt tcaacacgtt aagccaggta aaggagctgc tttcgttaga actaaataca
     7621 aaaacttaaa aacaggagct ataagagaag aaagtttcaa tccaagtgaa aaattcccta
     7681 aagctgttat agatacaaga caaatgcaat atctatacaa tgatggtgag ttatattatt
     7741 ttatggatca agaaaatttt gaacaaatac cattaaacta tgagcaagtt gaagatgcaa
     7801 ttaagttctt aaaagaaaat gaagttgcta caataagatt ttaccaagga caaccattcc
     7861 aagtggaagc gccaaacttt gcagagctag aagttacaga tacagagcca ggtataaaag
     7921 gtgatacagc aagtaatgta actaaagcag ctacagttga aactggagca gttgttcaag
     7981 ttccattatt tataaatact ggagataaag taaagataga tactagaaca ggtgaatatt
     8041 tatcaagagt ataaaaattt atgtatataa aagcttatat gtcttaataa tataagatat
     8101 atgagctttt agtttatata taaaaaagaa agcgaggggt gttacatgaa acatttatat
     8161 gaagaagttg catacttaaa aggcctagca gaaggactag aaataagtgc tgaaagtaaa
     8221 gaagggaaaa tgatacataa aatagttgat gcattagaag tatttgcaga tgctattgta
     8281 acattggatg aagaacaaga agaacttcaa gattttgttg aatctataga tgaagattta
     8341 gcagatttag aagaagatat tgctgacatg gaagaagatc tttatgaaga agatgacgat
     8401 gaggatgatg aggacttcag ctatatagaa atggaatgcc caaattgtgg agagttagta
     8461 gaaatagacg aagatttgtt atatgatgat gaagtagatg ttgtttgtcc tgattgtaag
     8521 gctgtgatat tatcatcaga agatgattgt gatgatgatt gtacatgtgg tggttgttca
     8581 agttgtgatg atagagagta aaaattcata agaattaaaa ctgcctatga tgcctatgag
     8641 atattttgct tcataggtag ttttattttt atgaggaagg gtattatgta ttttggtttt
     8701 gcaatacttg gacaaaaata gtacactaga atttatagaa taggattttg gagggatgta
     8761 aatatgaaaa taagtaaaaa attactagat aatatacaaa gatttgaaaa tgttataaat
     8821 tataaattta aaaataaaga atatatacta gaagctctta ctcatagttc atattctaat
     8881 gaaaataaaa aatataattt taacgaaaga ttggaatttt taggggattc ggttttaggc
     8941 atagtgataa gtgattattt atttaatgaa gaagctaatc tgcccgaagg ggaactaact
     9001 aaacttagag caaatatagt ttgtgaagat tcattaagtg aagtagctaa tgatataaat
     9061 ttaggtattc acatgttatt aggtagagga gaagaagcaa caggaggaag acataggact
     9121 tcaatattag cagacgcatt tgaagctgta atagctgcta tatatcttga tggaggtttt
     9181 gaaagtgcaa gacagtttat acttcatcat atggaaaata taatttatga ttcaagaaaa
     9241 ggaaatatat ttagagacta caaaacgcat cttcaagagg tgttacaagg gaatggagaa
     9301 aataatatct ggtacaggct tatagaagaa aaaggaccag accataataa aagatttgta
     9361 atggaagttg gaattaatga cgatgtactt ggtataggag aaggcaagag taaaaaagaa
     9421 gctgaacagt tagctgctaa aatagcttta aagaaaaaat tatgggaaaa ataaatataa
     9481 tatgtaaaaa tataaaaaga aatatttata ttagaaggat gttgtagatg aaaaagagaa
     9541 ttatacctat atttgttcct cacaaaggat gtcctcatga ttgcatattt tgtaatcaaa
     9601 aaaaaataac aggtgtgagt actgatgtta ctagtgaaga tgcaagaaat ataattgagg
     9661 aatgtttaga gactatagat aaagatgcag atgtagaaat agcatttttt ggtggtagct
     9721 ttactgctat agatattgat atacaaaaaa gtttattatc agttgctaaa gaatatgtag
     9781 aaaaaggtct tgtaaaagat attagaatgt ctacaagacc agattgtatt gatgaagata
     9841 tattaagtat gttaaaagaa tataagacaa gtataattga actaggagta caatccttag
     9901 atgaaaaagt attattagat agtataagag gtcatcaatc tgaaattgta tacaagagtt
     9961 caaagatgat aaaaaatagt ggaatcaaac ttggattaca gatgatgatt ggtcttccag
    10021 ctgacacaga agaaaagtgt atatttacag caaaaaaatt tgtagagcta aaaccagatt
    10081 gtgttagagt ctatccaact ttggtagtaa aagatacagg tcttgaaaag ttaatggaac
    10141 aaaataaata taatccattt actcttgaag agagtgtaaa tatagtaaaa aaagttcttg
    10201 tactgtttta tgttaataat atcaatgtaa taagagttgg gcttcaagct actgatgata
    10261 tacaaattgg aaaagctgtt ttagcaggac catatcatcc tgcatttaga gagttggtag
    10321 aagcagatat gataaaagat tatttagaat ttgttatttt gcaaaataaa aatataaagc
    10381 aaatgttggt caaatctaat aaaaagaata tttctaaaat cataggaaat aaaaaaacaa
    10441 atgttaaata tatggaagaa aaatttggtg tgcttttaaa aacacaagaa tcagatttag
    10501 atataaatca attagaaatt gtgttagatg ggaaaagttt aattagtgct aatatgagag
    10561 acattcatag aaaattgtat gacatttatg acctttagtt ttaataatga agggagagaa
    10621 aagatttgta tttaaaaaga ctagagttaa agggatttaa atcctttcca gtaaaaacag
    10681 atattatttt taaagaagga ataacagcca tagtaggacc aaatgggagt ggaaaaagta
    10741 atatatctga tgctgtaaga tgggtattag gagaacagag tattaagagt cttagaggtg
    10801 ataaactcga agatgtaata tttgcaggta cagatacaaa aaaacctatg aattattgtg
    10861 aagtggctct tactattgat aattctgaaa atcaattgga attagatttt acagaagtaa
    10921 ctataagaag aagggcttat agaaatggtg aaagtgaatt ttttctaaat aataaaagtt
    10981 gtagattaaa agatataaaa gaagtctttt tagatactgg tattggaaaa gatggttatt
    11041 caatcataga acaaggaaaa gtagatgaaa tattaagtaa taatccttta agcagaagaa
    11101 aagtttttga tgaagcttgt ggcatatcaa aatatagata taaaaaacag gaagcagaaa
    11161 ggaatttaag taatacaaag gaaaatttag aaagaataga tgatgtatat atagaaattg
    11221 aaaatcaatt aaagcctctt tttaatcaac agacaaaggc aaaaaagtac ttggaaataa
    11281 gtgaaaaatt aaagacactt gaagtaaata gctttataag agaaattgaa ggaatagaaa
    11341 aagaattaag tgaggttaat gaacatcgta aggttattga aaaggagctc aatgaaaaag
    11401 aagaacaaaa aaatgttgta gagaaaaagc aagaagatat taataaagag gtagaggtat
    11461 tacaagatgt aattgaaaaa tctgtagatt atataaattc aattaaagga gttatatcaa
    11521 aaaaagagtc ccaaataaat ttaattaagg aaagaataag aaattttacg aatgaaatta
    11581 gtagaaaaaa tttagaaata aaggatataa aagagaagct aaatgaaaat aagcaataca
    11641 taaaagaatt agaaagcaat aaattatcag gtagtgaaga actatctacc ttgcaggaaa
    11701 atataaaagt attggaagga agtaaagata aacaaaaaat taagttagaa tccctaaata
    11761 atgagataga attattgaaa gaaagtataa ttgatatatt aaataagaaa caagagttta
    11821 gtaataagct gtctacttta aacgcaaata aagaaaatat gaatatcaga gatgaaaata
    11881 taaattcaga gataacagag ttaaacaaaa atattgaaat aaaatcatct gaattagata
    11941 ctataaataa agaatttaat atgcaaaatg aaaatttaaa gaatgtaaat aatagacata
    12001 aagaattatc aattaatttg caggattcaa ttagtgaaca caataaacta gaagatgaaa
    12061 tacagaaaag taaatataat ttaaatggat ataattcaaa gttaaatgtc tatatagata
    12121 tggaaaatca ttatgaagga tttaatagag gagtaaaaga agtactaaaa aataaaaatt
    12181 taaaaggagt tcatggagca ttaggacaga ttataaatgt acctgaaaag tatgagaaat
    12241 ctatagaagc agctcttggt gcttatatgc aaaatataat aactgataat gagtttagtg
    12301 ctaagtttgc aataaactat ctaaaacaga ataatttagg tagagtaaca tttcttccat
    12361 taaatataat taaatcaaat aaaataagtc taggaaattt aaaagcaaat actaagttca
    12421 taggaatagc aagtgattta attacatttg atgaaaagta tagaaatata attgaaaata
    12481 tacttggaag aacaatactt ataaataata tagatgaggg cataaaattt gcaaaagaaa
    12541 ctggtcatag gtttaaaata gtaactttag atggtgaaat cttaaatcca ggaggttctt
    12601 tgactggggg aagtctaaaa actaatggga atatactatc gagaaaaaga tacattaatg
    12661 aatatacaga aaagataagt aatatcaaga atgaaatttc acatctagaa ttaaaaagag
    12721 aatctttaga caaagatgtg aaaaatatca aaaatgaaat tgattcacat gaaagtaaaa
    12781 taaaagattt agaaaaaagt ataataataa aaagtacaag tataaagaat gttgagtctg
    12841 aaattgaatc gttaaaaggt agtattacta aattagaaaa tgagaagaat gatttaaatt
    12901 ctaacctaaa ttatacactt gaaaaaagtg atgatgttag aaaagatatg gaagagttag
    12961 atgatttata caataaaaat aaagaaaaaa ttgatgcatt gaatgaggaa ataaaaagat
    13021 acaatgattt atatgataaa gaaaaatctg aatttgatga attgaactta agtttagtga
    13081 agaaaacaga agtttacaat agtatagtta gagatataaa aagaatatct ggtgaaaatt
    13141 gtgagctaga agaaaaaaat aaacaattag aagagtcatt aaattatgaa gaacatgaaa
    13201 taattaaatt acaagattct atactcactg aagaaaaaga aaaagaaaat ttaacaaaac
    13261 aactagggga tagtaataga aatcttgaaa ctagaaaaat agcaaaagat gatttaaaaa
    13321 atagttttga tgaaattaat aaagaattaa aaactataga tagacagcat atagaactta
    13381 aagaaagttt atttaaagtt ggtggaagat tagaaagatt aaaaactagt caagacacat
    13441 atataaataa gttgtttgag caatatgata tgaccttagt acaagcattg gaaattaaag
    13501 atgaagattt ggatatagat agaaaattct tagaaagtct aaagagagaa ataagaagtc
    13561 ttggaaatat aaatatagac tctataaagg aatatgagga aataaaagaa agatacgatt
    13621 tttatagcga acaaaagcaa gatttagaag agtctatgga agagatagaa aaacttatac
    13681 atactttaga agaaaatatg aaatctgaat ttgaaattaa gtttgaagaa ataagtaaaa
    13741 attttaaata tgtatataag agattatttg gtggaggttg tggagaatta actattttag
    13801 ataaagaaaa tttattagaa agtgatatac taataacagc tcaaccccca ggtaaaaaaa
    13861 tgaaaaattt aaacctatta tctggtggag agaaagcttt aacggcaata agtatattat
    13921 ttgctatatt gattacaaag ccaacaccat tttgtatatt agatgagatt gaagcgccac
    13981 ttgatgacgc aaatatattt agatttggag aatttttgaa ggatttatct aaagagactc
    14041 aatttatatc agtaactcat aggagaggaa caatggaagc tgctgattat atctacggag
    14101 ttacaatgca agaaaaagcc atttcaaaag ttattagttt aaaattaaaa gaagctcagg
    14161 aaataacaga tattatataa cttagattga cataggagga ataacagtgt taaaaaaatt
    14221 atttggtttt ggaaaagaca aggaaaagga aatagaaaaa aaagatgctg aagaagaaat
    14281 agaagttgaa gacagtgttg ataatttaga aaacttggaa gaaactattt tttcaggact
    14341 tgaagaagaa gtgatagata aagtggaaga tattgaagaa aaaaatgagg aaagtgtcaa
    14401 taatgaaggc actgaagaaa tcgaaaactt tgaaaaaata gaagttgaga tggatagtaa
    14461 tggaaaagaa gtagaaaata tttcaaataa tgattctcaa gaagagataa tcgaagaatt
    14521 agaaaattat gatgaaattg agtctaaaga gatagaagat aaagaagata agaaagttaa
    14581 cttgtttgaa agactaaaac aaggattgac aaaagcaaag caaggaataa ctgatagaat
    14641 agatgaagtt ttaaaatcat atacaaaaat agatgaagaa ttacttgaag atttagagga
    14701 aattttaata acagcagatg ttggtgtaaa tacaactatg gatataattg aaagactaag
    14761 agataaaata aagcaaaaag gtattactga accaataaag gtaagagaag aacttaaatc
    14821 tatagttgaa gatattctta caaatgaaaa ctctacacta gatatagaac cagcaccatg
    14881 tataatatta atggtgggtg taaatggggt cggtaagact actacaatag gtaaactagc
    14941 aaatagatac aaaaaagatg gtaaaaaagt tttattagca gcagcagata catttagagc
    15001 agcagcgaca gagcaattag aaatttgggc aaatagaacc aatgtagaca taataaaaca
    15061 tcaagaggga gcagaccctg gagctgtagt atttgatgct ataaaagctg caaaagctag
    15121 aaaaacagat gtattaatat gtgatacagc aggaagatta cacaataagg ctaatcttat
    15181 gaatgaactt ggaaaagtat ttaaaatagt agatagagaa tttccagaag caaaacgtga
    15241 agtacttctt gtggtggatg ctacaacagg tcaaaatgca gttgttcaag caaagacatt
    15301 taaagaagtt gcagatataa caggtatagt acttacaaaa cttgatggaa ctgcaaaagg
    15361 tggagtagtc cttgcagtaa aatcagaagt agatgtacct gtaaaactta ttggagttgg
    15421 agaaagtgta gaagacctac aagatttcaa tgcaaaatca ttttcagatg cattatttgg
    15481 taactaatgt tcttttaaaa ataatggttg acaagagtgt tgttatgata taaaatacaa
    15541 tagtgtaaag taaataacct ttacagtata ctgctaggaa gtgtaagata tgaatataga
    15601 aaaaatggtc gaaattggat tgttatttga acagtataaa gaattattaa ctgacaagca
    15661 gaaagaaata gttgctctat actatgaaga agattattct ttaggtgaaa ttagtgaaaa
    15721 tctgaatgta tcaagacaag gtgtttatga taccttaaag cgttcagaaa aaatactaag
    15781 agattatgaa gaaaagttac acttagtatc aaagattcaa gagcaggaaa aaaatattaa
    15841 gattataaaa gataaaatta ttgacattaa agaagattta ttgcacaata gagattgtgc
    15901 taatttaatc cctaagctag aaaatataga agatgtatgt agggagatga taaaatgata
    15961 tttgaaggat tgtctgataa actacaaggg gcatttagta agttaaaatc taaaggaaaa
    16021 cttacagaag tagatgtaaa aaatgctatg agagaagtta aacttgctct tcttgaggca
    16081 gatgttaact ttaaagtagt taaagatttc ataaaaaaag ttcaagagag atgtgttggg
    16141 caagaagtta tgcaaagctt aactccagct cagcatgtaa tcaaaattgt aaatgaagag
    16201 cttacaagtt taatgggaga tgtacaaagt aaagtaatga tttcctcaaa gcctcctaca
    16261 attttaatga tggttggatt gcaaggtgca ggtaagacta ctacagcagg aaaacttgga
    16321 ggatatttta aaaagcaagg taaaaaacct ctattagtag cttgtgatat ttatagacca
    16381 gcagctataa agcaacttca agttgttgga gaaaaattgg atatacctgt attcaatatg
    16441 ggagataaag aaaatccaat aaatattgcg aaagcaggtt taagccatgc gattaaaaat
    16501 gctaatgatt tagttattat agatacagct ggtagacttc atatagatga agtacttatg
    16561 gatgagttaa agtctattaa atcagaagtt aagccacatg agatactttt ggttgtagat
    16621 tctatgacag gtcaagatgc tgtaaatgtt gcagaaagct tcaatgaggc acttggtgtt
    16681 gatggagtag tattaactaa attggatgga gatactagag gtggtgctgc gctttcaata
    16741 agagcagtta cacaaaagcc tataaaattt atggggatgg gagaaaagct agatgatata
    16801 gaacctttcc acccagatag aatggcatca agaatattag gtatgggaga tgtcttaagt
    16861 ttaatagaaa aagcacaaga aaatatagac ttagagaaag ctaaagaatt agagcaaaaa
    16921 attaaaaaac aagagcttga ttttgaagat ttcttacaac aaatggaaca aatacaaaat
    16981 atgggacctc ttgacaagat acttggtatg atacctggta tgggaaatgt aaaagaccaa
    17041 cttggagatg tagatttgaa tggcaaagaa atgaagagaa caaaagccat aattcagtca
    17101 atgactacat atgagagaag aaacccagga gtattaaatg cttcaagaaa gaaaagaata
    17161 gctaaaggca gtggaactag tgtacaagat gtaaatagac ttataaaaca acttaatgaa
    17221 atgaaaaaaa tgatgaagat gtttgctggt tcacaaaaga gtatgaagaa aaggggcggc
    17281 ttaggcggtt tacctttttt taaataaaat ataaaaaagt aaaaattatt cggaggtgac
    17341 tgtaatggca gttaaaataa gattaaaaag aatgggagct aacaaaaaac ctttctacag
    17401 aatagtagta gctgattcaa gagctccaag agatggaaaa tttatagaag aaataggata
    17461 ctataatcca atttctgaac ctaaacaagt aagaataaat gatgaaaaag ctataaaatg
    17521 gttagctact ggtgctcagc caacagaagt agttaaaaaa ttacttgtaa aaaacggagt
    17581 aatagaaaaa ttcgaagctt ctaaacaagc aaaataattt tttcttggca attagtttaa
    17641 gtaagggctc attgctaagg ttactttagg agatgaaata tatgaaagag ctagttgtag
    17701 atatagctaa ggctctagtt gataatcctg actcagttgt tgttgaggaa tttgaagata
    17761 atgatggtat cgtcttaaag cttacagttg ctcaagagga tatgggtaag gttattggga
    17821 agcagggaag aatagctaaa gctataagaa ctgtcgtaag atctgttgca aatagagaaa
    17881 atataaaagt ttctcttgag atagtataaa ataggaggat taggtataat gcctagtcct
    17941 ttttatataa atgcgtagtt taagatttta tgatgatatg accacataag attaaatttt
    18001 ttaagaaggt gataacatga aagaaaaatt aactcatttt aaggtaggtc aaatagtaaa
    18061 tacacaaggt ttaaaaggtg aagtaagagt ttatccgctt actgatgata tagagaggtt
    18121 tgatgaatta aaagatttct atctgggaaa agatttaaat aataaattgg ctgttgaaaa
    18181 agtaagatac aaaggttcta tggttataat gaagataaaa ggcatagaca gcatagagaa
    18241 agcagaaaaa ctaaaaaata aatttatgta tgtagctaga gaagatagca gagagcttga
    18301 agaaggcgaa ttttttatag cagatatgat tggaatggaa gttttaactg tagatggaaa
    18361 atatgtaggg atactagaag atgttcttca atactcagca aatgatgtct atgtagtaaa
    18421 aggtgaggaa gataaagaat ttatgatacc agctataaaa aaatttgtac ctacaataga
    18481 tattgatgaa agaaaaatga ttatagaccc tattaaggga atgatagatt aggtggtaat
    18541 atgagatttc atataatgac actttttcca gaaatattta attcgtacat ggatgaaagt
    18601 ataatgaaga gagcagttga aaaaggtata attgaggttc atatatataa tataagggat
    18661 ttttctaata ataaacataa aaaagtagat gattatccat ttggaggagg agcggggatg
    18721 gtaatgactc ctcaacctat atatgacaca tataagcata taataacaac tcataatata
    18781 aataacccaa gtgtaattta tcttactcca aaaggtaagg tatacaatca atctatggca
    18841 aagcagatgt ctttaaaaga agatataata ctactatgtg gtcattatga aggaatagat
    18901 gagagaatca ttgatttaat agttactgat gaaatttcaa ttggagatta tgtattaact
    18961 gggggagagc tcccagcact tataatgata gattctatat cgagattaat accaggtgta
    19021 ttaaaccaag aagaatcatt tgaagaagaa tcatttaaag acaacttatt ggaatatcct
    19081 cattacacta gacctagaga ttttgaagga ttaaaagtac cagaagtgct tttatcaggg
    19141 aatcataaga agatagatga gtggagaaga gaagaatcta taaggataac caaagaaaga
    19201 cgatttgatt tatataaaaa atctaatgaa aaataaaaat ataatgaaaa attaatatat
    19261 atgtatacaa taaagtacct ataaatggaa ttaaaaacat aaaagtgctt gtaataacta
    19321 ttgaagtata gtataatata aaatgttgaa aatacgggcg ttcctctgtt tacactggtc
    19381 gggtagttaa gaacgtctat gatatctagg aggaagaaag atgaatgaaa tgctaagagc
    19441 aattgagcaa gaacaattaa aaaatgaagt tcctaatttt ggacctgggg acacagttaa
    19501 agtacacgtt agaattatag aaggaaaaag agaaagaata caagtattcg aaggtgtagt
    19561 attaaagaga caaggtggag gagcaagaga aactttcaca gttagaaaaa tgtctttcaa
    19621 tgttggtgta gaaagaactt tcccagttca ctctccaaaa atagaaaaaa tagaagttac
    19681 tagaaaaggt aaagtaagaa gagctaaact aaactactta agaggtagag taggtaaagc
    19741 tgctaagata aaagaagcta gaaataaata attaaaaact ttacttataa atggggggct
    19801 gatttatcag tcctctttct attttaatga aaattacagc aaataattat actagaaata
    19861 aatagaaata tttgttgaaa atatacatta tttatctatg aatttatagc ttttaaaatg
    19921 aaaaataaaa ttggtaaata ttgcattata ttttgtaaca atattaaaaa taagagaaca
    19981 gtattatgta aagtatgacg ttaaaaagat gacaatatta tagtttgtta agatagattt
    20041 tttaagtgga attaggatat aataatataa tattaataag gagtgataca tgtgtcaaat
    20101 gaatacgaag agtatcttat gaatgacaat ctacatataa actggtatcc aggtcatatg
    20161 aaaaaaacta aggagttagt aaaaaataac ttaaaattga ttgatgtagt aattgaactt
    20221 ttggatgcta gaatcccgtt tagtagtaaa aatccagaca tagacaggct tgtaggagat
    20281 aagccaagag ttgtcgtact taataagagt gatatggcag atagggataa attgaatcaa
    20341 tggattgaat actataagaa aattaatatc aaagctatac cagtagatac aataaaaggc
    20401 gttggtataa ataagataat cgaagaatgt aaaaatgtaa ctagagaaaa aatgagttct
    20461 ttaaaagaca aagggagaaa agaaagagct atacgaataa tgatagttgg agttccaaac
    20521 gttggtaaat cgtctcttat aaacaaatta acaggtagaa aaagcactca aactggagat
    20581 aagccaggag taacgaaagg gaaacaatgg gttagattaa agggaaatct tgaactttta
    20641 gatacacctg gaatactttg gcctaagttt gaagaccaag aagttgcatt aaatttagca
    20701 tttagtagag ctataaagga tgagatttta gatactgaaa ctttggcttt aagacttata
    20761 gagaaactta tgaaaataga acctgagaag ttgaaagcca gatataagtt agattgtcta
    20821 ggagaaactc caattgaaac tatggatatg attggccata aaagagggtt tataacaggt
    20881 aaaaaagaac tagattatac acgcatagcc acaactgtat taaatgaatt tagagatgga
    20941 aaaataggaa atataacatt ggaagttcca gaaaacgtta aaagatagat tttaaaacaa
    21001 aatcaaaaat ttaatgttaa aaatttaaaa aagcctttta gcaaaggctt ttttattttt
    21061 ttgaaatata gacaaatatc tccatataaa agtataaatt aggttagaaa acctttaaaa
    21121 atattaattt aagacaaata tacctaatat tttgaaaatt aaaatgagtg tgattattta
    21181 aaattttagc atattgactt gcttgtttcg tataatatat aataagcaca aataaataca
    21241 atatattaaa aatttaattt atttaatttt attaatttaa taataagttc ttattgttta
    21301 attcaactta cttatgcaag cgtaaacaat cgagacattt tattaattta ataaggttaa
    21361 aaagggggat tttataatgg gtaagaccaa ggatgttata gtatttggat ttgcgttatt
    21421 tgcaatgttc tttggagcag gtaacttaat atttccacct tacttgggaa taattacagg
    21481 tccagaatgg ttaattgcct tcttaggatt tacgtttgct gatgctggat tggcacttct
    21541 agcagtaatg gctacagcta aattcgatgg aaacgtagtt gaaatgttta aaagatgtgg
    21601 tatgaagtta ggaattctta taggttgtgc agatatttta tgtataggac cattcttagc
    21661 tataccaaga acaggtgcaa caacttatga aatgggtata atgcctttgt ttggaacttc
    21721 aattccagtg ttattattct gtatactttt ttttgcgatt tcatatgtac taacaataag
    21781 accttctaag gtcgtagata tagttggaca gtttttaact ccagctcttc taatagcttt
    21841 agcatttata attataaaag gtattatatc acctcttgga gatatagtag ataaacctat
    21901 gatacctaat gtatttgcag aaggtatagg tcaaggatat cagacaatgg atgcttttgc
    21961 agcaatagca cttgcatcag tgctaatagt atctttaaat gataaaggat attctactat
    22021 tagtgacaag ttgaaaatga ttggtaaggc gggtgttctt gcttgtggag gattagctct
    22081 agtttatgga ggattatgtt tccttggggc aactgtatca acaatgtatg gaacagatgc
    22141 agtacaatca caagtaatag taaatataac tgaaggattg cttggaaatg ttgggaaagc
    22201 gattttagca gtagtagtat cattagcatg tttaactaca tctataggtc ttacatctgc
    22261 cacaggtcaa tatttctcta gacttacaaa aggtaaattg agttatgaaa aaatagtatt
    22321 agctgtatct gtattcagtg cagtagtagc atcttttggt gttggaacta taataaagat
    22381 agcatctcct atactaagta tagtttatcc accatcaatt gttttaataa ttttagcttt
    22441 cttcaatgaa aaaattaaga atgataatgt atacaaagga gcagtatata tgtcattgtt
    22501 tgtaagtata ctaacagtta tatctagtta tggagtagct gttccagtag taaattcttt
    22561 acctcttaat tcattaggat ttaactgggt ggtgccagtt ataatagctg gaataattgg
    22621 taattttata ccatcaaaga gtcaatctaa tacacttgga acaaactaag ttttgtttaa
    22681 ttaaaatata atcaattgta aataaatgag ttaactaaaa gtaaaaggag ttatttgtac
    22741 aaataactcc ttttattttt agattctata tttaattatt tgtatttaat atggaaaaag
    22801 tataagaaaa tatcaaaaaa atatatggtt tattttttaa caataataga gattaaaaaa
    22861 gaattttaga gtaattttat aaatttaagt atacatatta aatgattttt acaaaaatat
    22921 aatataaata aaattgtgac aataataaaa taataaaaca aaatttaaga catatgatta
    22981 tataaatgta ttaaataaat gagtaaattg ttttcattga gagatatatt aagaattttt
    23041 agttaattat gacatataag tatgtaaacg tgaatactag caactgcaaa gtttaagtaa
    23101 gttggaagtt agagagtaat tgttatgaag aaaaataagt tgataaatca taataaggaa
    23161 ttttcagaaa aaatggtttt aagagtaaaa aacaagaggc aaatctacgc aagtagaata
    23221 aaaattgaat aaagttaact gtcaatttag caaaataaat acaaaatact acaagaatta
    23281 acgtaaatag gtgttatgat aaaaggaaaa cgatttttta agaatcataa ttttgaaaat
    23341 taaaaaaatt aaaaatgcta ttgactgctt ttttttcaga ttatataata aacacaaaat
    23401 atttaaaatt taaattgaat taaaaagatt atatgaatgt aaaaaaggag agtgatatat
    23461 acagtatata aagcaataca acttaataat aaatcgaata atctaaaaag tcttaatatt
    23521 ttaattattc ggaatagtta attttatcaa gaaaaattag agaaaaaaca aaaaaccaac
    23581 tatgtttaaa gtatacaggt tgattttgtt taattaagaa agttgtatta aatattgtga
    23641 agattttata aattatgaaa cataattgac aaatttaagt caaaaatgta taattaaata
    23701 aaatctcgtc aaaaggtttt catttaatta agagattgga cttatttttt agtaaaaggt
    23761 agtaaaattc aaatgggggt gctttaaatg ggtgagaaac aaatcaattt taaagatgta
    23821 attgtaattg gatttgcact atttgcaatg ttttttggtg cagggaactt aatcttccct
    23881 ccatatctag gagttttatc tggaagtagt tggctagtag ctttcatagg attccttttt
    23941 gcagatggtg gtttggcatt attagcagtt atagcagcaa ctaagttcaa tggagacaca
    24001 tcgaagatgt tctcaagggc aggcaaagga ttaagtattg cattaggatg tgcaatggta
    24061 atctgtatag ggccactttt agcaatacct agaacagcag caacaactta tgaaatgggt
    24121 atattaccta caataggttc tggaataagc ccagtaatat tctctatagt attctttgct
    24181 ctagtattgg ttttaacaat aagaccatca aaagttgtag atatagttgg gtcaatatta
    24241 actccagctt tacttatagc tttagcagta ttaatagtta aaggtatcgt atctccatta
    24301 ggagaaataa gagacagttc tttaatacaa aatgtatttg cagaaggtat aactcaaggt
    24361 tatcaaacaa tggatgcatt ggcagctagt gtatttgcat caattataat catgtcagta
    24421 atagctaaag gttatacagg tgagaaagaa aagatgaaag ccacaataag tgcaggtgta
    24481 attgcagtaa taggaatggc attagtttat ggtggattat gttatcttgg agcaactgtg
    24541 tctcaacaat atggacaaga tgttcaacaa acagctttaa tagttgcaat aacagcagct
    24601 ttacttggaa ctacaggtaa aattttattg gctattatag ttgcattagc atgtttaaca
    24661 acagctatag gtctttcttc agcagctggt caatatttct caacacttac agatggaaaa
    24721 ttaaagtatg agcatatagt tatagtagtt tgtgtattta gtgcaatcat atcaaacttt
    24781 ggagtaagta caataataca attctcttct cctatactaa gtatggtata tccagcaact
    24841 ataactctag ttatactagc attatttagt aataaaatta aaaatgacaa cgtgttcaaa
    24901 tgtgctgcat acatggcatt attagtaagt gtattaacag ttgcaacaag ttttggtgta
    24961 aaaattcctc tagttaatag cttaccattt gcttcattag gatttaactg gatagttcca
    25021 gttgtaatag caggaataat aggaaacttt attccatcta aaagcagtaa aactgcataa
    25081 taataaaaac taattgataa ttatggaatt gcctttaaat tatataggca attccttttt
    25141 atatttaaaa gaattattaa attattgtag ataaaagaac attattaatc ctgtttgata
    25201 aatttaaaaa tttatttttg aagt
//
LOCUS       DAEHWM010000054        25190 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.055, whole genome shotgun sequence.
ACCESSION   DAEHWM010000054 DAEHWM010000000
VERSION     DAEHWM010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25190)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25190)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25190
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.055"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            183..1244
                     /locus_tag="KNP36_002258"
     CDS             183..1244
                     /locus_tag="KNP36_002258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium/sodium antiporter"
                     /protein_id="HBF0874124.1"
                     /translation="MEKRKSIHLHKLNIYLIGGGDRLFITVVLFLVGFLLITKGADIF
                     INCTVEIGKKTNISEIILGATIVSFATTLPEFTVSLLASIDGHTTMSLGNAVGSIICN
                     TGLALGLVVFISPFNVDKKMFFSKSLLLIVSVIVLILLSLDGVITRGDSLLLIIILIF
                     YMVNNYRSVVGKSDTKNRNIKNNTIKDISTKKGKNYRGFSVLEIVKILLLFATGLIMM
                     IIGSQILIESGVIIASFLNIPQGIVSLTIIALGTSLPEIVSSITAIRKNHHEISVGNI
                     LGANILNIVSVIAVSAIPNNIPILSQNRQLDIPFMILLLLIVIIPTLKSNKLSRIQGI
                     LMLFTYFLYISILYFMYII"
     gene            1335..2948
                     /locus_tag="KNP36_002259"
     CDS             1335..2948
                     /locus_tag="KNP36_002259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBF0874125.1"
                     /translation="MNITKFEDLPISEGIKKAIAEMGFEEPSPIQAQSIPAILSGKDV
                     IGQAQTGTGKTAAFSIPILETIDPNNRSLQAVVLCPTRELAIQVSTEIRKLAKYSHGI
                     KTLPIYGGQPIDRQIKSLKSGVQVVIGTPGRTIDHINRKTLKMDNVKMIILDEADEML
                     DMGFREDIEMILSKIPEERQTTFFSATMPRGILELTKRYQKDPEHIKVVRKELTVSNT
                     KQYYIETRSSNKLEVLCRLVDVYDPKLSVVFCNTKRKADELVGDLQARGYFADALHGD
                     LKQTQRDIVMDKFRNGTIDILVATDVAARGIDVDDVECVFNYDLPQDEEYYVHRIGRT
                     GRAGREGMSFTFVFGKEMRKMKDIERYTKSKLIKHNIPTITDVEEKKVGTFFAQVKQT
                     IEEGHLTKQLQWLEGFCNDEDYAMVDIAAALVKLSLGEEMKEEIIEEKPRRERGDRKG
                     GTGAKDGMIRLFINIGRNQRVQAKDIVGAIAGEVGIPGKVVGTIDIYDKYTFVEIPKK
                     DAKTVIEKMKDIKIKGNKINIEKANKKKK"
     gene            3223..5208
                     /locus_tag="KNP36_002260"
     CDS             3223..5208
                     /locus_tag="KNP36_002260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBF0874126.1"
                     /translation="MSMTYMDPRVFLILEMVLEEDTNTLEQFSNVLGVSTRTIRNYIN
                     QINRELKGGIAKIVKNEKGTYSIRIEDESKLIEIVNFNRGKLSNFINLNSPDERINYV
                     LDILTMTNNPITIDDLAEEICIGRTTLIKDLKKADRILAEYDLELKRKPNIGMILVGE
                     EMDIRLLILDRLYENYIDVLENVNQINLVKDYDIECLRDELKKLFKKEELYITEQVLR
                     DVERYIIMSVLRNLNGYKFEKIDKRFEVIRCSDEYTLGLKLKALLEKIFNIVLNEKET
                     IFLTMPLIGRKAPSTKLALSSIKINDSVKEVVDEVTSFLLETSGIDFKEDKKLIENLE
                     YHLYFALNRMRFNIRVKNPLLQEIKERYTFPYSVAKIAAMIIEEKFDLKICDHEIGYI
                     ALHFGSYFEKNSRKVLNVNRVAVVCGTGLGTAQLIRIKIGKILGESVEVNTFSDIEAK
                     ANLDLLKYYDLVFTTVDFKTDLDVPIFRVNALFNEESIKKEIENAILLKNSINLKSIK
                     KIEKNIPFIGKLIEEDKFFILNKSTFMENLEDMLEKLVHKGIIDIEFKKKVLKREKKS
                     STALDNYIALPHSVNTNGENLYLAFGILEKPVIWDTKEIRIIILMIIPDKNVDSTDLI
                     IKSYEEVLEVGRDKKMVEELAKAKSFDEFYKIITKRR"
     gene            5213..5647
                     /locus_tag="KNP36_002261"
     CDS             5213..5647
                     /locus_tag="KNP36_002261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator GutM"
                     /protein_id="HBF0874127.1"
                     /translation="MDPVIFIIASLITVYLLNIFLGYLQLKDFNKNYIELKRKGRVAI
                     GRKKGRISSGTIVLILINDDGVIVETRKMQGVTVLARVKSFEGLVGKNLEYIEKSDLT
                     VYNKLLKKAILDAVKQYITFEKNKCEDTNNLSTDEECRMEVV"
     gene            5676..6236
                     /gene="srlA"
                     /locus_tag="KNP36_002262"
     CDS             5676..6236
                     /gene="srlA"
                     /locus_tag="KNP36_002262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418408.1"
                     /note="catalyzes the phosphorylation of incoming sugar
                     substrates along with their translocation across the cell
                     membrane; the IIC domain forms the PTS system
                     translocation channel and contains the specific
                     substrate-binding site; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="HBF0874128.1"
                     /translation="MTQFFQVLASGADSFMNLFRAGGQQFVGFVTDIVPLLVALLVTM
                     NAIINFIGTDRVERLAKKCSANIFTRYLILPVLGTFVFANPMTLSLGRFLPEKFKPSY
                     FAAASFSCHTMNGLFPHINPGELFIYLGIANGITTLGFSTADLAVRYLLVGIVANFIK
                     GVVTDYTTKFVEKQQGIALNSDIKIG"
     gene            6300..6668
                     /locus_tag="KNP36_002263"
     CDS             6300..6668
                     /locus_tag="KNP36_002263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sorbose transporter subunit IIB"
                     /protein_id="HBF0874129.1"
                     /translation="MAFNKVKIVKGSGGWGGPLIIEPTEKKNKVVYVTGGAKPETAVK
                     IAELTGCELIDGFSQGVKDDEIACVIINCGGTLRCGIYPQKKIPTINIMKTGKSGPLA
                     MFIKEDIYVSGVKPTNVEQL"
     gene            6693..7259
                     /locus_tag="KNP36_002264"
     CDS             6693..7259
                     /locus_tag="KNP36_002264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="HBF0874130.1"
                     /translation="MAYDTKKKISEQSQGIVAKIGIALGNVTSTLFQAGRDTIDTLIH
                     TILPFMAFVAVLIGIINQSGIGNWVANLLTPLIGNVGGLVVLSIICSFPLLSPFLGPG
                     AVIAQIVGVLVGTEIGKGNIPPSLALPALFAINSQAACDFIPVGLGLAEAEPDTVQVG
                     VPSVLYSRFLTGAPTVLLAWLASFGLYK"
     gene            7300..7665
                     /locus_tag="KNP36_002265"
     CDS             7300..7665
                     /locus_tag="KNP36_002265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="HBF0874131.1"
                     /translation="MELIYSTQINKIGDNANEFLQHNMFVTFKDNAPQELENYCYIHS
                     ENNLVKEILTDDVLSINNVDYKITSVGELVNQNLSELGHITFKFTGEKDGAIGGTLYL
                     EEKEIAPIGVGTILKIIRK"
     gene            7766..8539
                     /gene="srlD"
                     /locus_tag="KNP36_002266"
     CDS             7766..8539
                     /gene="srlD"
                     /locus_tag="KNP36_002266"
                     /EC_number="1.1.1.140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sorbitol-6-phosphate dehydrogenase"
                     /protein_id="HBF0874132.1"
                     /translation="MRKVALVVGGGRSLGEYLSKHLAKVGYDVAIADLNEDNAKKVAE
                     EIKTEFGCKSVGYSCNAIDERQVISTVKAIENDFDRIDLLVYNAGVAVSKKITDFGYK
                     DFKFIVDVNLNGYFLFAREVSKVMIAKGIEGRIIQINSKSGRVGSKHNSGYSAGKFAG
                     VGLTQSLALDLAEHKITVNALMLGNLLDSDMFESLIPQYAVKLGIPESEVKQVYIDKV
                     PLKRGCRFIDVANMLTFYASKEAEYCTGQSINITGGQVM"
     gene            8888..11032
                     /locus_tag="KNP36_002267"
     CDS             8888..11032
                     /locus_tag="KNP36_002267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBF0874133.1"
                     /translation="MDIIKKLSHGCTLDCHDCCKFNVYTKGNNVVKIEGDKNHPYTKG
                     FICKKGMAHLDRLNHKDRIKTPMLKVDGVWKEISFDKAIEIMAEKLTYYKEKYTSKSV
                     MHYDQYGSGSVLKYIGDIFFNFYGGVSRHKGGPCWSAGMHAQKYDFGVAKSHAIEDML
                     NSKSIFVWGKNPAYTTIHTMQIIKKAKEKGIKIVVIDPIYTKTAQIADKYVQVNPGTD
                     GALAIAMAKIIVEDKLYDEEYINSYVIGFEEYKKYLSSLELSFLIDECGVKENDIREL
                     VDLYTNKYSSINVGYGLQKYKNGGNTIRAIDALGAITGQIGFSGGGVNYANKVYPSVI
                     NSDPYNSQSYGEDREFYVSNISKFIEESLKNTSNKVNYASDELDMTSNKVNYVSDELD
                     ITSNKTDYISNELYNLSNKSIKGNIPIKMAVITKSNMLNQLPDLVELERVFSKIEFKV
                     CFDMFITDTATLCDMFIPCTNTLESEDIIYSSMTNPYITYNERAVKPAHKLMDEYYFF
                     MELAKKMGLNDYPFVEKRTYLEKVIEPLKRFDKNLDIEKLKNNYFTIHNPVAWEDKKF
                     ETPSGKYELYSESIKNLGISPTPVYISNKYKEIEDKNISFRLLTNHHADTLFSQHFMD
                     KKSIAQAYINRRMAKKVGIEDKDIVILRSKKAKINVQINIDDGVGNYIVKMYVGWWKK
                     HGNPNSLTDTGISDFGGQVTYNESMVEIIRQN"
     gene            11120..11455
                     /gene="spoIIAA"
                     /locus_tag="KNP36_002268"
     CDS             11120..11455
                     /gene="spoIIAA"
                     /locus_tag="KNP36_002268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma F factor antagonist"
                     /protein_id="HBF0874134.1"
                     /translation="MVNYSLEHKNLYIEFMCSELDHHVANEIREEIDNLLSVNQVKNV
                     VFNFENINFMDSSGIGVIIGRYKKISNEGGRVSVINISSRVKKIFDLSGLNKIIGIYD
                     TYEEALSSL"
     gene            11469..11897
                     /locus_tag="KNP36_002269"
     CDS             11469..11897
                     /locus_tag="KNP36_002269"
                     /EC_number="2.7.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anti-sigma F factor"
                     /protein_id="HBF0874135.1"
                     /translation="MNNIMEVKFSAISENESLARVIVASFAAKLDPTVDELVDIKTAV
                     SEAVTNAIIHGYEEDSSKFVFLRCEIEGNTIKIIVEDEGYGIENVEKAMEPLYTSKPE
                     LDRSGMGFTVMKSFMDDVEVSSVKDNGTRIEMTKKINVPK"
     gene            11920..12684
                     /gene="sigF"
                     /locus_tag="KNP36_002270"
     CDS             11920..12684
                     /gene="sigF"
                     /locus_tag="KNP36_002270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sporulation sigma factor SigF"
                     /protein_id="HBF0874136.1"
                     /translation="MEVTVAREEKKPLLSHEETLELIEKVQNGDEEAKEILISSNLGL
                     VRSVVSRFLNIGYDREDLFQLGSIGLIKSIYKFDPKFNVKFSTYAVPMILGEIKRYLR
                     DDGMIKVSRSLKQIAIKAKMESEALTKKLGREPSIEELAKAIDVEKEDLVMAMEANFN
                     VEYLQGVIHEEEGSPICLIDKISMKGESEEEKVVDNILLKDILGRLDKRERQIIVLRY
                     FEDMTQSEIGEMLNISQVQVSRIEKKVLSKLKEYIS"
     gene            12964..13401
                     /gene="spoVAC"
                     /locus_tag="KNP36_002271"
     CDS             12964..13401
                     /gene="spoVAC"
                     /locus_tag="KNP36_002271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AC"
                     /protein_id="HBF0874137.1"
                     /translation="MDKNYKKYVDQISPKPTYLKNYTLAFIVGGIICMIGQAINDLYM
                     KVGGLDKLGASSATSITLIFIGAFLTGLGVYDLIGKRAGAGSIIPITGFANSIVSPAM
                     EYKREGYVLGVGANLFKIAGPVLVYGIGSSILCGIIYYIFKMF"
     gene            13568..14581
                     /gene="spoVAD"
                     /locus_tag="KNP36_002272"
     CDS             13568..14581
                     /gene="spoVAD"
                     /locus_tag="KNP36_002272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AD"
                     /protein_id="HBF0874138.1"
                     /translation="MKNKRIGKRTVKLENKPTIISTGTIVGPKEGEGPLKDYFDMIMT
                     DDLYGEKTWELAESKMVETASQQAIQKAGKKLSDVNYMLGGDLINQIVPASFAARELA
                     IPFLGIYGACSTMAEGLCIGSMLIDGGFADLVLSGTSSHYCTAERQFRFPLELGNQKP
                     MTAQWTVTGAGSVLLAPNGDGPKVKYVTVGKVIDEGIDDGNNMGPAMAPAAIDTIYSY
                     FEDTNDDPNSFDIIATGDLGTLGKQIAEDFLKEKGVDISKVYTDCGIEMFNLKEQDVH
                     CGGSGCGCSATVFAGYIYDKLRKKEFNKVMLVSTGALLSPTSTLQKQTIPCVAHAVVI
                     VNE"
     gene            14595..14957
                     /gene="spoVAE"
                     /locus_tag="KNP36_002273"
     CDS             14595..14957
                     /gene="spoVAE"
                     /locus_tag="KNP36_002273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage V sporulation protein AE"
                     /protein_id="HBF0874139.1"
                     /translation="MLMDYVRVFIVGGIICLIAQVMMDYFKMQTPYVMVTYVTTGVVL
                     TFLGLYEPLVKFAAAGATVPIIGFGYSLATGVIKSIQSDGFLGIFLGGTTATAGGIAA
                     AIFFGYIMSVVFTPKAKP"
     gene            15140..16156
                     /locus_tag="KNP36_002274"
     CDS             15140..16156
                     /locus_tag="KNP36_002274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBF0874140.1"
                     /translation="MVTIKDIARNLGISYSTVSRCLNNNPNVSEKTKKKVVEEANRLG
                     FHFNVNARNLAKKETNRIGVIFSNNFNHQDTRKFFSDIMDSSINSIETNKYDFIIQPN
                     NNISGDSNVYKMVNGQMVDGLVIVSQSIKKEEYDFLKDNNFPHVFIYFKPSFIGEVDN
                     FFWDDNVYGGYIATKHLIDHGHKDIITVTSDDKSSKMHEDRTKGYLNAMEEANLKTEV
                     IKSKMDFESQVEFLEKYIDKIKKASAIFVQQDVPAISIIQELKTTYGINVPEDISIIG
                     YNNIELISYFRSHLSTIDDPREQVIKNGVDSLVNIINKKSTEHIPRKLYPRLIIRNSV
                     KRIK"
     gene            16531..17373
                     /locus_tag="KNP36_002275"
     CDS             16531..17373
                     /locus_tag="KNP36_002275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3100 domain-containing protein"
                     /protein_id="HBF0874141.1"
                     /translation="MKEKAGIRNAIIAAFIITILAELIGPISFKVMGINVTLLSILWA
                     IFIGMAVSPHLLGRVIPALKKFIGDNEINVSPYLLSLTLYPLGIMFGINAGPKVGILL
                     QAGPALLLQEFGHMGTMLIALPVGVALGLGRSALGGTFSLCRDTALGIIGDKYGLNSP
                     EGIGTLGTYISGSIFGTLLFSFLAPVGVLLGFHPYALAMASGMGSGSMMGAATASLMN
                     TVPQMSEQILAYSATSGLITAVTGIYIELFLSLPVANYYYSKVAPVIERFRGRKTRRT
                     SNKL"
     gene            17388..17852
                     /locus_tag="KNP36_002276"
     CDS             17388..17852
                     /locus_tag="KNP36_002276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874142.1"
                     /translation="MEKTFKTIMEQIKIVLFIYIIICFGQMIALKTQAQDLLIGSVSG
                     FLLVIIAIIIKNFVKKPNLPGFAWATLVAFVLSLPISPVGDIIATNVGKINFMSTVTP
                     LLAFAGISVGNQLDILKTLSWKLVVISFIVMTSTYFGSAFISQTVLRLNGML"
     gene            17839..19011
                     /locus_tag="KNP36_002277"
     CDS             17839..19011
                     /locus_tag="KNP36_002277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0874143.1"
                     /translation="MECFKEVVNMNELKAKIKEEIKLLSEEKKTSFEKVSDYLFSNPE
                     LAFEEYKSQKALCDLLEENEFNVTKGVGGLETSFEAVYSNGTNGKTVAFLAEYDALPG
                     MGHACGHNIIGTSSVGAGIILKEIMKKHNIEGTVKVFGTPAEERVGGKITMIKEGVFN
                     NVDAALILHPSDASMPDDISFAQVNLKFDFTGKASHAAAFPWEGKSALSGVIALFNSV
                     NSMRLHLKDYARVHGIITDGGSIHNIIPEKSTAIFNVRALSIEYLNEICEMLKNCAKG
                     AAISTGTNVEIVQLDEIYKEIKNDSELVNIVRQNFEVLGEDYVERDLSQGIGSTDTGN
                     LTHEIPAIQAYIKLKENTATHTDEFAVAAGGEEGRVALIKAIKVLAMCGVDILYSK"
     gene            19055..19990
                     /locus_tag="KNP36_002278"
     CDS             19055..19990
                     /locus_tag="KNP36_002278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1177 domain-containing protein"
                     /protein_id="HBF0874144.1"
                     /translation="MILKQVIEVYDILDKANANGEEVKTYLQGYGEVDVTVKELSSSK
                     GSTDLVKLTIPGKNGKLKGGDAPTLGILGRLGGIGARPEVIGFVSDGDGALVAIAVAA
                     KLLDMQRKGDILDGDVVISTHICPDAPTKEHYPTPFMDSPIDMMTMNENEVDSSCDAI
                     LSIDTTKGNRVINTRGFAISPTVKEGYILKTSDNLLDIMQTVTGKSPFVFPLSIQDIT
                     PYGNNLYHLNSILQPAVATDAPIVGVAITTEMPVAGCATGATNFSDLDSAGRFAIEVA
                     KLFGRNKCDFYDKEEWEMLIKRYGKLNRFQTFGIQ"
     gene            complement(20264..22957)
                     /locus_tag="KNP36_002279"
     CDS             complement(20264..22957)
                     /locus_tag="KNP36_002279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase domain-containing protein"
                     /protein_id="HBF0874145.1"
                     /translation="MNNDNDKNGNKIRRKKVSSSGNTNKPINRTSANKTRSTKNKKKS
                     KKSDKFKKLRVFGIVFLVLLVVGTAGTAGLVFASLRDVTPVTEAVLDKQTNQTTTIKY
                     ANGKTLSTAPSVNKKTPVPLDKISPYLQHAVIAIEDERFYEHKGVDIKGLFRSVLKTL
                     TGTKQGGSTIPMQVSKMLLTTEQQTIPRKIKDIYYAHEMSKTVSKDKILETYLNNFFV
                     GRGLAGAEAGARGYFDKSAADLTLAESALLAGSTKNPSRFSAYKTSKLEGNETKEDLE
                     NKLLFFVNTTDDDLDDPTQVDFDMIEKIKSWELISNDTYRQLKAGTLVVRKAVSNPEA
                     KKRQEIVLKKMLELKYIKQSEYDEAIKAKIEIKLPQSSDKVSSSVEDLIESEVINALM
                     EQGHTNDEAQNLFYNGGLIVNTTIDPKMQDALEEEFDRNSNFPGHMVGPDGVSQPQAA
                     MVILDYKNGEIRALAGGRNISGRKTLNRATNPHQPGSSIKPLAIYTPAIDTLKITQAT
                     ALSDSRGGYKFEENNKWNPRTTTAGHGSMSLRKALAKSSNTIAVKTAEMLGDSYDECV
                     DIMMDYLKNFGITTLKNNHSGSSEASDRKFPSLTLGGMANGITPLQMAAAYGTLANHG
                     IYVEPSIFTTITTFDGQLLVKNAPEEHKVVDPEVAYVVTDMLESVITEGTGGVATLPK
                     GMPVAGKTGTTNSAYDAWFVGYTPYYVGATYIGDDAGRKDDSGNTIKRREVPHGSTST
                     AKLWEKIMEKIHANLTVTEFEVPKNVYFTKINLEDGGKQSSGSKAAFIEGTAPTKVSS
                     QPSSEDTKKPDNNQPEENNNNNNNTGDNGGGSTPPDNGGNNGGGSTTPPDNGGNNGGG
                     STTPPDNGGNNGGGSTTPPDGGGNNGGGSTTPPDGGGTPAT"
     gene            23171..23869
                     /gene="yunB"
                     /locus_tag="KNP36_002280"
     CDS             23171..23869
                     /gene="yunB"
                     /locus_tag="KNP36_002280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418439.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation protein YunB"
                     /protein_id="HBF0874146.1"
                     /translation="MNRIVDRKTKNEFRKIIAIFLVILFLSVFIGSFIYIDKTLRPTI
                     TVLAETKALELANRSINKAVAEMVEGKINYEDLMDIQLDNNGKITMIQANTIMMNEIA
                     SAIALEIQDELKKDKTASSYIPIGTALGSPILAKYGPKLEVSIEPIGTVSVNFKTEFE
                     SSGINQTRHRIYLEAQTQVKVVIPLITSTKQIKAQIPICETIIVGDVPESYVNIPEKN
                     LGNVLPNTGKNTNK"
     gene            complement(24081..25088)
                     /locus_tag="KNP36_002281"
     CDS             complement(24081..25088)
                     /locus_tag="KNP36_002281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase S55"
                     /protein_id="HBF0874147.1"
                     /translation="MQLKNFHFKNNTLSKKTNLAKSKFTIVLTFLFLLYFFSNNLIYA
                     QNLQKNEPEYLIPIGNVLQIDAELKNIIVRNPGEASPFRLGDAIVKVNNAEVDGYSDF
                     ANTLNALPEEKQVSILLNRGGQLITMKTTKHILEKISFNNLLSGFATLTYINPDTSEF
                     GAVGHPISVGNARKIPIKTGSISTTKHLNIEKSYKGSVGCINAKRENIIGSFTENTDF
                     GIRGQINNFDISKLKKYKVASLDEVKLGKAQIILQDNFNKCKKYNIEIIDIENQKHPE
                     SKSFKIKITDKKLLAQTGGIVQGMSGTPIVQDNKIIGAVSHAIENDPAVGYGVFIKWM
                     L"
BASE COUNT         9590 a         2891 c         4469 g         8240 t
ORIGIN      
        1 tagcatatta ttcgtatcct gtatacataa aaaataaaaa attgtcgctt taaagtataa
       61 aacagattat atgttaataa tgtggtgaaa ttatacccat atataaataa aataaaacaa
      121 ataaatagct aattaaggag aaaatatttt ttattttttg tttaggataa ataaatttta
      181 ttatggaaaa aagaaaaagc atacatcttc acaaactgaa tatttattta atagggggag
      241 gtgatagatt gtttatcaca gtggtattat ttttagtagg tttcctatta attactaaag
      301 gcgcagatat ctttataaat tgtactgtag agataggtaa aaaaacgaat atatcagaaa
      361 ttatacttgg agctactata gttagttttg caacaacatt acctgagttt acagtgtctc
      421 tacttgcttc tattgatggt catactacta tgagtttagg aaatgcagtt ggttctataa
      481 tatgtaatac agggttagca ttagggttgg ttgtttttat aagtccattt aatgtagata
      541 aaaaaatgtt tttttctaag tctttactat taatagtatc cgttatagtt ttaattttat
      601 tgagtttaga tggagttata acaagaggtg attcattatt acttataata atattaatct
      661 tttatatggt taataattat agaagtgtcg ttggaaaatc tgatactaaa aatagaaata
      721 ttaaaaataa cactattaaa gacatatcta ctaaaaaagg gaaaaattat agaggttttt
      781 ccgtattaga aattgtaaaa atactattac tttttgctac aggattgata atgatgataa
      841 taggttcaca aatccttata gagagtggag taataatagc tagtttttta aatatacctc
      901 aaggtatagt aagtttaact ataatagcac ttggaacttc tctgccagag atagtttcgt
      961 cgattactgc tataagaaaa aatcatcatg aaatatcagt aggaaatatt ttgggtgcaa
     1021 acatattgaa tatagtatca gtaatagctg tatcagcaat accaaataac ataccaatac
     1081 tatctcaaaa tagacaattg gatataccat tcatgatatt attattatta atagtaataa
     1141 taccaacact taaatctaat aaacttagta gaatacaagg tatattgatg ttattcacat
     1201 attttctgta catatcaatt ttgtatttca tgtatattat ttaactatac tgtttaaaat
     1261 attaattgca gaatatccta aaaaagtata taatggatag gttaagatta attgataacg
     1321 gagaggaata atatatgaat ataacaaagt ttgaagattt accaataagt gagggaataa
     1381 aaaaagctat agctgaaatg gggtttgaag aaccatctcc tatacaagca cagtctatac
     1441 ctgcgatttt gtcaggtaaa gacgttatag gacaagctca aactggtacg ggaaaaacag
     1501 ctgcttttag tatccctata ctagaaacaa tagacccaaa taatagaagt ttacaagctg
     1561 tagtgctttg tccaacaaga gaactggcaa tacaagtatc aacagaaata agaaagttag
     1621 ctaagtattc gcacggaata aagacattac ctatatatgg tggtcagcca atagatagac
     1681 aaataaaatc tctaaagagt ggtgtgcaag ttgtaatagg tacaccagga cgtacaatag
     1741 accatatcaa tcgtaaaaca ttaaagatgg ataatgtaaa aatgattata ttagatgaag
     1801 cagatgaaat gctagatatg ggatttagag aagatataga aatgatttta agtaagattc
     1861 cagaagaaag acaaacaact ttcttttcag ctactatgcc aagaggaatt ttggaattaa
     1921 ctaagagata tcaaaaagac ccagagcata taaaagttgt tagaaaagaa cttacagttt
     1981 caaatacaaa gcaatactat atagaaacta ggtcatcaaa taaattagaa gtattatgta
     2041 gattagtaga tgtatatgac cctaaactat ctgttgtttt ctgtaatact aagagaaaag
     2101 cagacgaatt ggtaggagat ttacaagcaa gaggatattt tgcagatgca ttacatggtg
     2161 acttaaaaca gactcaaaga gatatagtaa tggataagtt tagaaatggt acaatagata
     2221 tacttgttgc tactgatgtt gcagctagag gtatagatgt tgatgatgtt gaatgtgtat
     2281 tcaactatga cttaccacaa gatgaagaat attacgttca tagaattggt agaactggtc
     2341 gtgctggtag agaaggtatg tcatttactt ttgtatttgg aaaagaaatg agaaagatga
     2401 aagatataga aagatatact aaatctaaac taataaagca taatatacca acaataactg
     2461 atgttgaaga gaaaaaagta ggtactttct ttgcacaagt taaacaaact atagaagaag
     2521 gtcacttaac taaacaatta caatggttag aaggtttctg taatgatgaa gattatgcaa
     2581 tggttgatat agctgctgca cttgtaaaac tatctctagg tgaagaaatg aaagaagaaa
     2641 taatagaaga aaaacctaga agagagcgtg gagatagaaa aggtggtact ggagctaaag
     2701 atggtatgat tagattattt atcaatattg gtagaaatca aagagtacaa gcaaaagata
     2761 tagttggtgc catagctgga gaagttggaa taccaggtaa agtagtaggt actatagata
     2821 tatatgataa gtatactttt gttgaaatac ctaaaaaaga tgcaaaaaca gtaattgaaa
     2881 agatgaaaga tattaagata aaaggtaata agattaatat agaaaaagca aataagaaga
     2941 aaaaataacg tatagtatac aaaactataa ttagaaaata tataaaataa tatattggat
     3001 atttaaaaag cctgatgtgt tttcaaaaca gatagtagat aatctgtaag agttaacagc
     3061 ataaggcttt tcttgtttta tatgatgtta taattttcca gattgttgtg aaaaatgtat
     3121 attagttcct ttttttcaaa tctgatttga aaaagagaat attaattatc tatatagttt
     3181 agattataat aaaaaatgta agataacaaa ggggagaaaa agatgtcaat gacttatatg
     3241 gaccctaggg tttttttgat tttagaaatg gtgttagaag aagacacaaa tactctagaa
     3301 caattttcaa atgttttggg tgttagtact aggactatca gaaactatat aaaccagatt
     3361 aatcgagaat taaaaggtgg tattgctaaa atagttaaaa atgaaaaagg tacatatagt
     3421 ataagaattg aggatgaaag taaattaatt gagattgtaa attttaatag aggaaagcta
     3481 tcaaatttta taaatttaaa ttcacctgat gaaagaataa attatgttct tgatatttta
     3541 actatgacca acaatccaat taccatagat gatttggctg aagagatatg tataggaaga
     3601 acaacattaa taaaggattt aaaaaaagca gacagaattt tagctgaata tgatttagaa
     3661 ttaaaaagga agccaaatat aggtatgatt ttagttggtg aagaaatgga tataagatta
     3721 ttaatccttg atagattgta tgaaaattat attgatgtct tggaaaacgt taatcagata
     3781 aatttagtta aagattatga tattgaatgt cttagagatg aattaaaaaa gttatttaaa
     3841 aaagaagaac tctacataac agaacaggtc ttgagagatg ttgaaagata tataatcatg
     3901 tctgtcttaa gaaatctaaa tgggtacaaa tttgaaaaga tagataagag atttgaagtg
     3961 ataagatgtt cagatgaata tactttagga ttaaagctca aagctttatt ggaaaagata
     4021 tttaatatag ttttaaatga aaaagaaacc atatttttga caatgccatt aataggtaga
     4081 aaagctccta gtacaaaatt agcacttagc agtataaaga taaatgatag cgtaaaggaa
     4141 gttgtagatg aagtaactag ttttttatta gagacctcag ggattgattt taaagaagat
     4201 aaaaagctta tagaaaattt ggaatatcac ttgtattttg cacttaatag aatgagattc
     4261 aacataaggg taaaaaatcc tcttttacaa gaaataaagg aaagatatac atttccatat
     4321 agtgttgcaa agatagctgc aatgataatt gaggaaaagt ttgacttgaa aatatgtgac
     4381 cacgaaatag gatatatagc attacatttt ggaagttatt ttgaaaaaaa ttcaagaaaa
     4441 gttctaaatg taaatagggt agctgttgtt tgtggaacag gtcttgggac tgcacaactt
     4501 attagaataa agataggaaa aatacttgga gaaagtgtag aagtaaatac tttttctgat
     4561 atagaagcta aagctaattt agatttatta aagtattatg atttagtatt tacaacagta
     4621 gatttcaaaa cagacttaga tgttccaatt tttagagtaa atgcgttatt taatgaagaa
     4681 agtataaaga aagagataga aaatgcaata cttttgaaaa atagtataaa tcttaagtct
     4741 ataaaaaaga ttgaaaaaaa tatccctttt ataggtaaat taattgaaga ggataagttc
     4801 tttatattga ataagagtac gtttatggaa aatttagaag atatgttaga aaaattagtt
     4861 cataaaggaa ttattgatat agagttcaaa aaaaaggtat taaaaagaga aaagaaatct
     4921 tcaacagcat tagataatta tatagcattg cctcactcag ttaatactaa tggggaaaat
     4981 ctttatctgg catttggaat attagaaaaa ccagtgattt gggatacaaa ggaaattaga
     5041 ataataatat tgatgataat tccagataag aatgtagata gtacagacct gataataaaa
     5101 agttatgaag aagtacttga agtagggaga gataaaaaga tggtagaaga acttgctaag
     5161 gcaaaatcat ttgatgaatt ttataaaata attaccaaga ggaggtaata atatggaccc
     5221 agtaattttt attatagcat cacttattac agtgtattta ttaaatattt ttcttggata
     5281 cttacagctt aaagatttta ataaaaatta tattgaacta aaaagaaaag gaagagtggc
     5341 aattggcaga aaaaaaggaa gaatttcatc gggtacaatt gtgttgatac ttataaatga
     5401 tgatggtgtg attgtcgaga ctagaaaaat gcaaggtgtt acagtattgg caagagtaaa
     5461 gtcatttgaa ggtttggtag gaaagaactt agagtatata gaaaaatcag atttaactgt
     5521 ttacaataaa ctacttaaaa aagcaatact agatgcagtc aaacagtaca taacatttga
     5581 gaaaaataaa tgtgaagata caaataatct gagtactgat gaagagtgta ggatggaagt
     5641 agtttaaaaa aatatattta taaggaggag ttaatatgac gcaatttttt caagtattag
     5701 caagtggtgc agatagtttt atgaatttat ttagggcagg tgggcaacaa tttgtaggtt
     5761 ttgtaacaga tatagtacca cttttagtag cattattagt tacaatgaat gcaattatca
     5821 actttattgg tacagataga gtcgagagac ttgcaaaaaa atgttctgca aatatattta
     5881 ctagatattt gatattacca gtccttggta catttgtatt tgcaaaccca atgacactat
     5941 cattaggaag attcttgcca gaaaagttta aacctagtta ctttgcagca gcaagctttt
     6001 catgccatac aatgaatgga ttattcccac atatcaatcc aggtgaacta tttatatatc
     6061 taggaattgc aaatggtata acaactttgg gattctcaac agcagattta gcagttagat
     6121 atttgttagt gggtatagtt gcaaacttta ttaaaggtgt agttactgac tatacaacaa
     6181 aatttgtaga gaaacaacaa ggaatagcat taaattcaga tataaagatt ggataattac
     6241 tttaaggtat aaataaattt ttcaaataaa aagatagtgt atagaggagg ataaattata
     6301 tggcatttaa caaagttaaa atagtaaaag gttctggagg atggggtgga ccattgataa
     6361 tagaaccaac agaaaagaag aataaggtag tatatgtgac tgggggagca aagccagaaa
     6421 ctgcagtaaa aatagctgaa cttacaggat gtgagttaat agatggattt tcacagggtg
     6481 ttaaagatga tgaaatcgca tgtgtaataa taaattgtgg tggaacattg agatgtggta
     6541 tatatcctca aaagaaaata ccgactataa atataatgaa aacaggaaaa agtggaccat
     6601 tagcaatgtt tataaaagaa gatatatatg tttcaggggt aaaaccaaca aatgtagagc
     6661 agttataatt gaggtagtag gagggaagaa atatggctta tgatactaaa aagaagataa
     6721 gtgagcagag tcaaggaatt gttgcaaaaa taggtatagc actaggaaat gtgacaagta
     6781 ctctttttca agctggtagg gatactatag atacattaat acatactata ctgcctttta
     6841 tggctttcgt tgcagtccta ataggtataa taaatcaatc aggtatagga aattgggtag
     6901 ccaatttact tactccatta atcggaaatg ttggaggttt agttgtctta tcaataatat
     6961 gttcatttcc gttgttgtct ccgtttcttg gaccaggagc tgttatagct cagatagtgg
     7021 gagtattggt tggtacagaa ataggaaaag gaaatattcc accaagttta gcattaccag
     7081 cattgtttgc aataaactca caagcagctt gtgactttat accagtaggt cttggtcttg
     7141 cagaagctga acctgataca gttcaagtag gagttccgtc agttttatat tctagatttt
     7201 taacaggtgc accaactgtt ctattagcat ggttagcaag ctttgggtta tataaataga
     7261 agaatacttt ataaataatt agagagaggt tcagttgata tggaattaat atacagtact
     7321 caaataaata aaataggaga taatgcaaat gaatttttac aacataatat gtttgtaact
     7381 ttcaaagata atgctcctca agagttagaa aattactgtt atatacattc tgaaaataat
     7441 ttagtaaaag aaatacttac ggatgatgtg ctatcaataa ataatgttga ttacaaaatt
     7501 acttctgttg gtgagttagt aaaccaaaat ctttcagaat taggtcatat aacatttaag
     7561 tttacaggtg aaaaagatgg agcaattgga ggaaccttat atcttgaaga aaaagaaata
     7621 gcacctattg gcgtaggtac tatactaaaa ataattagaa aataaaattt aaaacgaatc
     7681 taatcatatt ataagtaaat tatagataaa agtcaattta actaatcaag ttaactttta
     7741 atgtgataaa aaaggggaaa tgaaaatgag aaaagtggct ttagtcgttg gaggaggaag
     7801 aagtttaggt gaatatttat ctaaacattt agctaaagta ggttatgatg ttgctattgc
     7861 agatttaaat gaagacaacg caaaaaaagt agctgaagaa ataaaaactg aatttggttg
     7921 taaatctgta ggatatagtt gtaatgccat agatgaaaga caggttataa gtactgtcaa
     7981 agctattgaa aatgattttg atagaataga tttattagtg tacaatgcag gagtggctgt
     8041 aagtaaaaaa ataactgatt ttggatacaa agattttaaa tttattgtag acgtaaattt
     8101 aaatgggtac tttctatttg caagagaagt atctaaagtc atgatagcaa aaggtattga
     8161 gggtagaata atacagataa attcaaaatc aggtagagtg ggaagcaagc ataattcagg
     8221 atattcagca ggtaaatttg ctggagtagg acttactcaa agtttagcgc tagatttggc
     8281 agaacataag ataactgtaa atgcactgat gctcggtaat ttacttgatt ctgatatgtt
     8341 tgaaagttta attcctcaat atgcagtaaa attgggaata cctgaatcag aagtcaagca
     8401 agtttatata gataaagtac ctttaaaaag agggtgtaga tttatagatg ttgcaaatat
     8461 gcttacattt tatgcttcaa aggaagctga atactgcact ggtcaatcta taaatattac
     8521 tggtggacaa gttatgtaag gtttttatgg agtgtctcaa gatgaactct ttagttcatg
     8581 aggcactttt ttgtataaaa ttaaatatat tttcagcatt taaacaatga aaaagaggtt
     8641 tatctttatt ttgagatagc ctcatttttg taattaaaaa acatagtgtt taagtaaaca
     8701 tataagattg ttagtttttt aaaagagaat tttttaataa tattatattt atgaagtatt
     8761 tttaaactta ttttgataaa atatagctat gttttatata ctgtagtttt gaacatagaa
     8821 agtttaataa attatagtat atatgttaat ttttaataag gtaagaaagt agaaagaagg
     8881 atattttatg gatataataa aaaaattaag tcatgggtgt acattagatt gtcatgactg
     8941 ttgtaaattc aatgtttata ctaaaggaaa taatgtagta aaaattgaag gagataaaaa
     9001 tcatccttat acaaaaggtt ttatatgcaa aaaagggatg gcccatttag atagattaaa
     9061 tcataaagat agaataaaga ctcctatgct taaagttgat ggagtatgga aagagatttc
     9121 ttttgataaa gctatagaaa taatggcaga aaagcttaca tactataaag aaaagtatac
     9181 atcaaagtct gtcatgcatt atgaccaata tggaagtggg tctgtgctaa aatacatagg
     9241 agatatattt tttaattttt atggaggtgt tagcagacat aaaggtggtc cctgttggag
     9301 tgcagggatg catgctcaaa aatatgattt tggagtagct aagagtcatg ctatagaaga
     9361 tatgttaaat agtaaaagta tatttgtgtg gggaaaaaat ccagcatata ctacaattca
     9421 tactatgcaa ataattaaaa aagctaaaga aaaagggata aagatagtag tgattgaccc
     9481 catatataca aaaacagctc aaatagcaga taagtatgta caagtaaatc ctggaacaga
     9541 tggagcttta gctatagcta tggcaaaaat tatagtagaa gataaattat atgatgaaga
     9601 atatataaac tcgtatgtta ttggttttga agaatataaa aaatatttat cttcattgga
     9661 attaagtttt ttaattgatg aatgtggtgt taaagagaat gatataagag agttagtgga
     9721 tttatatact aacaaatatt caagtataaa tgttggatat gggcttcaaa aatataaaaa
     9781 tggtggaaac acaataagag caatagatgc tttaggtgct ataactggtc aaataggatt
     9841 tagtggtgga ggggtaaact atgctaataa agtttatccg agtgttataa attctgaccc
     9901 ttacaatagc caatcatatg gtgaagatag ggagttttat gtaagtaata tcagtaaatt
     9961 tatagaagaa tctttaaaaa atacatcaaa taaagtaaat tatgcatcag atgaacttga
    10021 tatgacatca aataaagtaa attatgtatc agatgaactt gatataacat caaataaaac
    10081 agattatata tcaaatgaat tgtataattt atctaataag tcaatcaaag gtaatattcc
    10141 tataaagatg gctgtaataa ctaaaagtaa tatgctgaat caactgccag atttagtaga
    10201 attggagagg gtgttttcaa aaattgaatt taaagtatgt tttgatatgt ttataactga
    10261 tacagctact ttatgtgaca tgtttatacc gtgtacaaat acactagaga gtgaagatat
    10321 aatttatagc tcaatgacca atccatatat aacctataat gaaagagctg taaagccagc
    10381 acataaattg atggatgaat attacttctt tatggagcta gctaaaaaga tgggattaaa
    10441 tgattatcct tttgtagaaa agagaactta tttagaaaaa gtgattgaac cacttaagcg
    10501 ttttgacaaa aatctggata tagaaaaact taaaaacaat tactttacta tacataaccc
    10561 tgttgcttgg gaagataaga agtttgagac tccatctgga aaatacgagc tttattcaga
    10621 aagtataaaa aacttgggaa taagtccaac acctgtatat ataagcaata aatataaaga
    10681 aatagaagat aaaaatattt cttttagatt attaactaat catcatgcag atactttatt
    10741 tagtcagcat tttatggaca aaaaatctat agctcaagca tatataaatc ggagaatggc
    10801 taaaaaagta ggtattgagg acaaagatat tgtgatattg aggtcaaaaa aagcaaaaat
    10861 aaatgtacaa ataaatatag atgatggagt aggtaattat atagtaaaaa tgtatgttgg
    10921 ttggtggaag aaacatggaa atcctaatag tttaacagac actggtatat cagattttgg
    10981 gggtcaggta acatataatg aaagtatggt agaaataata cgacaaaact agttaaattt
    11041 cattgaagga ataaaaatat aattatagaa ttgattaaaa gttactattt ttacaaaact
    11101 attgaaggag ggatttttga tggtaaatta ttccttagaa cataagaatc tatacataga
    11161 atttatgtgc tcagaactag accaccatgt agccaatgaa ataagggaag aaatagataa
    11221 cttattaagt gtaaatcaag taaaaaatgt tgtatttaat tttgaaaata ttaattttat
    11281 ggattcttca ggtataggcg tcatcatagg tagatataaa aagatttcta atgaaggggg
    11341 acgagtttca gtaattaata taagttcacg agttaagaag atttttgatt tatctgggtt
    11401 aaataaaatt attggcattt atgatacgta tgaagaagct ctaagttctt tgtagggagg
    11461 agtatgtgat gaataatatt atggaagtta aattttcggc aatatctgaa aatgaaagtt
    11521 tagcaagagt tatagtagca tcctttgcag ctaagttaga cccaacagta gatgagttag
    11581 tagatataaa aactgctgtc tctgaggctg ttacgaatgc tataatacat ggatatgaag
    11641 aagacagttc taagtttgtt ttcttaagat gtgagataga aggaaatact ataaagatta
    11701 tagttgaaga tgaagggtat ggaatagaaa atgtggagaa ggcaatggaa ccactttata
    11761 catcaaaacc agaacttgat agatcaggaa tgggattcac agtaatgaaa agctttatgg
    11821 acgatgtaga ggtaagttct gtaaaagata atgggactag aattgaaatg actaaaaaaa
    11881 taaatgtgcc taaataaagt ccaaaagtga ggttttatta tggaagtaac tgttgccaga
    11941 gaagaaaaaa aacctcttct tagtcatgaa gagactctag aacttattga aaaagttcaa
    12001 aatggagatg aagaggcaaa agaaatatta atatcaagca atttaggtct agttaggagc
    12061 gttgtatcta gatttttaaa tataggatat gatagagaag atttatttca gttaggttct
    12121 ataggcttaa taaaatcaat atataaattt gacccaaaat ttaatgtaaa attctctact
    12181 tatgcagtac caatgatttt aggtgaaata aagagatact taagagatga tggtatgata
    12241 aaagtatcaa ggtcgttaaa gcaaatagct ataaaggcaa agatggaaag tgaagcttta
    12301 actaaaaaat taggtagaga gccgagtata gaagaattag ctaaagcaat agatgtagaa
    12361 aaagaagatt tagtaatggc tatggaagct aatttcaatg ttgagtattt gcaaggagtt
    12421 attcatgaag aggaaggttc tccaatatgc cttattgata aaataagcat gaaaggagaa
    12481 agtgaagaag aaaaagtagt ggataacata ttgttaaaag acatacttgg aagactggat
    12541 aagagagagc gtcaaataat agttctcaga tactttgaag acatgactca aagtgaaata
    12601 ggagagatgc tcaatatatc acaagttcaa gtatctagga tagagaagaa agtattgtct
    12661 aagttaaaag aatatatatc gtgataatac ttatgatatg tagaataata aaatataata
    12721 aatatattac taaaataaaa tgtaataact ttttatgtta agtttttaaa ttattaaaag
    12781 atattaaaat aataaaaagc attaaaaaag taaaaatata aaaacaaggt gtctttatgg
    12841 aaaaatagat tttttcttta ttaggcatct tttttatttt ttgaccaaac tttagatagt
    12901 caaaataaat aataggttta tttttttaaa attaacaaat aatactttag agaggtgttt
    12961 agtatggata aaaattataa aaaatatgta gaccaaataa gcccaaaacc tacatattta
    13021 aaaaactata cacttgcatt tattgtaggt ggaattattt gtatgatagg gcaagcaata
    13081 aatgatttgt atatgaaagt tggaggtctt gataaactag gtgctagttc tgcaacatca
    13141 ataacattaa tatttatagg ggcattttta actggattag gagtttacga cctaatagga
    13201 aaaagagctg gagctggttc tataattcca ataacaggtt ttgctaactc aatagtatct
    13261 ccagcaatgg agtataaaag agaaggctat gtattaggtg taggtgcaaa cttatttaaa
    13321 attgcaggac cagttttagt ttatgggata ggttcttcta ttttatgtgg aattatttat
    13381 tatattttta agatgtttta gatgattttt atttaattta aattttatta attatgaaga
    13441 aggtataaaa tctgaaaata gctactaaag taactaattg aaaaataatt ctgcagattt
    13501 aattaatatt tttaattaat attaaaaatt tgaatagtaa aatgcaaaat taaaaaggtg
    13561 tgaaaatatg aaaaataaaa gaattggaaa aagaacagtc aagttagaaa ataaaccaac
    13621 cataatatca actggaacta tagtaggtcc taaggaaggt gaaggaccac taaaggacta
    13681 ttttgatatg attatgactg acgatttata tggtgaaaag acttgggaat tagctgaaag
    13741 taaaatggta gagactgcat ctcaacaagc tatccaaaag gcaggtaaaa aattgtcaga
    13801 tgtaaattat atgctaggtg gcgatttaat aaatcaaata gttccagcat cctttgcagc
    13861 aagagaactg gctattccat ttttaggtat atatggagct tgttctacaa tggcagaagg
    13921 tctttgtata ggttctatgc ttatagatgg tggttttgct gatttagtac tgtcaggtac
    13981 atcaagtcac tattgtacag cagaaagaca atttagattc ccacttgaac ttggaaatca
    14041 aaaaccaatg acagcccagt ggacagttac aggagcagga agtgtattat tagctcctaa
    14101 tggagacggt ccaaaagtaa agtatgttac tgttggtaaa gtaatagatg agggtattga
    14161 tgatggtaat aatatgggac cagctatggc tccagcagca atagatacta tctactctta
    14221 ctttgaagat actaatgatg acccaaatag ctttgatata attgctactg gagatttagg
    14281 tactcttgga aaacagatag cagaagactt tctaaaagaa aaaggtgtag atatatcaaa
    14341 agtttatact gactgtggta tagagatgtt taaccttaaa gaacaagatg tccactgtgg
    14401 tggaagtgga tgtgggtgtt cagctacagt gtttgcagga tatatatatg ataagttgag
    14461 aaaaaaagaa tttaacaaag taatgcttgt atcaacagga gcactacttt caccgacaag
    14521 tacactacaa aagcagacaa taccatgtgt tgcacatgca gtagtaatag taaatgagta
    14581 ggaagtgata taatatgtta atggactatg taagagtatt tattgtaggt ggaattatat
    14641 gtttaatagc ccaagtaatg atggattatt tcaaaatgca aactccatat gttatggtaa
    14701 cgtatgtaac aactggtgta gttttaactt ttctaggact ttatgagcca ttagttaagt
    14761 ttgcagcagc aggtgcaaca gttcctataa taggatttgg atattcactt gctacaggag
    14821 taataaaatc aattcaaagt gatggttttt taggtatttt tttaggaggt acaactgcta
    14881 cagctggtgg aatagcagca gctatattct ttggatatat tatgtcagta gtatttactc
    14941 caaaagcaaa accataaatc tttattaaaa gaataataag tttttgaaat aataactttt
    15001 tataaagcag gtggatatct tttagattcc acctgttttt tatataaaga agcgtttaca
    15061 taattgaagt tgacaattat ttacaacata gtgtagtatt atattatcaa aataaaatga
    15121 agtgaagtag gggataaaga tggtaactat taaagatatt gcaaggaatc taggtatcag
    15181 ttattcaact gtttctaggt gcttaaacaa taatcctaat gtatctgaaa aaacaaaaaa
    15241 gaaagtggta gaagaggcaa atagactagg gttccatttt aatgtaaatg caagaaattt
    15301 agcaaaaaaa gaaactaaca ggataggggt aatcttttca aataatttta atcatcaaga
    15361 tactagaaag ttttttagtg atataatgga tagttctata aattctattg agactaataa
    15421 atacgatttt ataatacagc ctaataataa cattagtggt gatagtaatg tatataaaat
    15481 ggtaaatgga caaatggttg acggattagt aattgtgtct caatcaataa aaaaagaaga
    15541 gtatgatttt ttaaaagaca ataattttcc acatgtattt atatatttta aaccatcttt
    15601 tataggagaa gtagataatt tcttttggga cgataacgtg tatggaggtt atatagctac
    15661 caagcattta attgaccatg gtcataaaga tataataaca gtaacttcag atgataagag
    15721 ttcaaaaatg catgaagata gaaccaaggg atatttgaat gctatggaag aagcaaattt
    15781 aaagacagaa gtcattaaat ctaaaatgga ttttgaatct caagttgaat ttttagaaaa
    15841 atacattgat aaaataaaaa aagcttcagc tatatttgta caacaagatg taccagcgat
    15901 ttctataata caagagttaa aaactactta tggtataaat gtaccagaag atatttccat
    15961 aatagggtat aataatattg aattaatatc atattttagg tcgcatttat caacaataga
    16021 tgacccaaga gagcaagtta taaaaaatgg agtagatagt ttagtaaata taataaataa
    16081 aaagagtaca gaacacattc caagaaaatt atatccaagg ttaataatac gaaatagcgt
    16141 taaaagaata aagtagtaag cttttaagta tcaaacgttt attaaaaata ttatagatta
    16201 tgtgaagttt tttaacaaat aatataaata aaaattaaaa ggagtaggtg tatataagta
    16261 cattgtactc ctttatttat tgagatagtt tttataatat gaatgaataa ttttattcaa
    16321 ttatttgaaa atccgttatt ttaacaatat aaattaataa attatttgta ttttatatca
    16381 tgaatctata atattttttt gattcataac taaaagtata taaaaatgat gaataaatat
    16441 atattataca ttatcaatga taggttatat aataaaatca ctaacaatta tattataaga
    16501 aaattataaa aattacaagg aggtatagaa atgaaagaaa aagcagggat tagaaatgcc
    16561 ataatagcag cctttataat cacaatattg gcagaattaa ttggacctat ttcatttaaa
    16621 gttatgggaa ttaatgtaac tttacttagt atactatggg ctatattcat aggaatggct
    16681 gtttctcctc atttattagg gagagttata ccagccttaa aaaagtttat aggggataat
    16741 gaaataaatg tatctccata tttattatct ttgacactat atccattagg gataatgttt
    16801 ggaattaatg cagggcctaa agttggtata ttacttcaag caggaccagc acttttatta
    16861 caagaatttg gtcatatggg tacaatgttg atagcattac ctgttggagt agcattaggt
    16921 cttggaagaa gtgcattagg tggtactttt tcattatgtc gtgacacagc actaggaatt
    16981 attggagata agtatggatt aaactcacca gaaggtatag gaacactagg aacttacata
    17041 agtggtagta tatttggaac attattattt tcatttttag caccagtggg tgtactttta
    17101 ggatttcatc catatgcttt agcaatggca tcaggaatgg gtagtggttc aatgatggga
    17161 gctgcaacag catcattaat gaatacagtt ccacaaatgt cagagcagat tttagcatat
    17221 tcagctacta gtggattgat tacagctgtt actggaatat atatagaatt attcttatct
    17281 ttaccagtag ccaactacta ttatagcaaa gtagctccag ttattgaaag atttagagga
    17341 agaaaaacaa gaagaacaag taataaattg taaaggagga tatatatatg gaaaaaactt
    17401 ttaagactat tatggagcag ataaaaatag tattgtttat atatattatt atttgctttg
    17461 gacaaatgat agcacttaag actcaggctc aagatttgtt gattggaagt gtatctggat
    17521 ttttgttggt gataattgct attataataa agaattttgt taaaaaacct aatttaccag
    17581 gttttgcatg ggctacatta gttgcatttg ttttatcgct tccaatatct ccagtggggg
    17641 atatcatagc aacaaatgta gggaaaatca attttatgtc tacagtaaca ccattattag
    17701 cttttgcagg aatctctgta ggtaatcaat tagatatatt aaagactttg agttggaagt
    17761 tagtagttat atcatttata gttatgacat ctacttactt tggttctgct tttatatctc
    17821 aaacagtttt aagattaaat ggaatgcttt aaggaggtag taaatatgaa tgaattaaaa
    17881 gcaaaaatta aagaggaaat aaagttatta tctgaagaga aaaagacatc atttgaaaaa
    17941 gtttctgact atttattttc aaatccagaa ttagcatttg aggagtataa gtcacaaaaa
    18001 gcattatgtg atttgttaga agaaaatgaa tttaatgtaa ctaaaggtgt aggaggatta
    18061 gaaacatctt ttgaagctgt gtattcaaat ggaactaatg ggaaaacagt tgctttttta
    18121 gctgaatatg atgcacttcc aggaatggga catgcatgtg ggcacaatat catagggaca
    18181 agttctgttg gtgcaggtat catattaaaa gaaatcatga aaaaacataa tatagaaggg
    18241 actgtaaagg tttttggaac acctgcagaa gaaagagtag gtggaaaaat aactatgatt
    18301 aaagaaggtg tatttaataa tgtagatgct gcattaattt tacatccaag tgatgcttca
    18361 atgcctgatg atatatcatt tgctcaagtt aatttaaaat ttgattttac tggtaaggca
    18421 tcacatgctg ctgcttttcc ttgggaaggg aaaagtgcct taagtggagt aatagcacta
    18481 tttaacagtg taaatagcat gagattacat cttaaagatt atgcaagagt acatggaatt
    18541 ataactgatg gaggtagcat acataatata attcctgaaa aatctacagc tatatttaat
    18601 gtaagagcct taagtataga atatttaaat gagatttgtg aaatgcttaa aaattgtgct
    18661 aaaggagctg caatttctac tggaactaat gtagaaatag ttcaattaga tgaaatatac
    18721 aaagagatta agaatgattc tgaattagtg aatatagtta gacaaaattt tgaagttttg
    18781 ggtgaagact atgttgaaag agatttaagt caaggtatag gttcaactga tacaggaaat
    18841 ttaactcatg agatacctgc aatacaagca tatataaaat taaaagaaaa tactgcaact
    18901 catacagatg aatttgctgt tgcagctggt ggtgaagaag gcagagtagc acttataaaa
    18961 gcaattaagg tgttagcaat gtgtggagta gatattttgt atagtaaata atatataatt
    19021 ttaaaatata ttaagaaagg aaatcggatt agacatgata ttaaaacaag taatagaggt
    19081 ttatgacatt ttagataaag caaatgctaa tggggaagaa gtaaaaactt acttacaagg
    19141 ttatggtgaa gtagatgtaa ctgtaaaaga attgtcttca agtaaaggtt caacagattt
    19201 agtaaagctt acaattcctg gaaaaaatgg aaaattaaaa ggtggagatg ctcctactct
    19261 tggtatttta ggtagactag gagggattgg agcaagacca gaagttatag gttttgtctc
    19321 agatggtgat ggagcattgg tagcaattgc agtggctgct aaacttttgg atatgcaacg
    19381 aaaaggggat atattagatg gtgatgttgt aatttcaact catatttgcc cagatgctcc
    19441 aactaaagaa cactatccta ctccttttat ggattctcca attgatatga tgactatgaa
    19501 tgaaaatgaa gttgatagta gttgtgatgc aatactttct atagatacta ctaaaggaaa
    19561 tagagtaatc aatactagag gatttgcaat atcgccaact gttaaagaag gctacatatt
    19621 aaaaactagt gataaccttt tagatattat gcagactgta acagggaaat ctccatttgt
    19681 attccctttg tctattcaag atataacacc atatggaaat aatctgtatc acttaaatag
    19741 tattttacaa ccagcagtag ctacagatgc accaatagta ggagtagcaa ttacaacaga
    19801 gatgcctgtt gctggatgtg ctacaggtgc aactaatttt agtgatttag attcagctgg
    19861 gagatttgca attgaagttg ccaagctatt tggtagaaat aagtgtgatt tctatgataa
    19921 agaagagtgg gaaatgctta ttaagagata tggcaaatta aatagatttc aaacatttgg
    19981 tatacagtaa ttagaaaaat attaagttta tataatttgt gatataacta tttaagaata
    20041 tataaacaat taggaataaa agtaagaata aagcacttag ttaaaaactt taaaaataaa
    20101 atatttattt gtttatataa aaaggaggat tctggttatt gggattctct tttttatgaa
    20161 tacaaataat atattgtaat tataaaaaaa ggagcgtttc aaagtgattt ttttaatcac
    20221 cttgagacaa ctccttatat ttttatttaa attctatttt ttattaagtt gctggagttc
    20281 caccaccatc aggaggagta gtagagccac caccattatt tccaccacca tcaggaggag
    20341 tagtagagcc accaccattg tttccgccat tatcaggagg agtagtagag ccaccaccat
    20401 tatttccgcc attatcagga ggagtagtag agccaccacc attgtttccg ccattatcag
    20461 gaggtgtaga accgccacca ttatcacctg tgttattatt gttattatta ttttcttctg
    20521 gttggttatt gtctggtttt tttgtatctt cagatgatgg ttgagaactt actttagtag
    20581 gagcagtacc ttcaataaat gctgctttag agccagaaga ttgctttcct ccatcctcta
    20641 aattaatttt tgtaaaatat acatttttag gaacttcaaa ttcagtaacc gttaaattag
    20701 catgtatttt ttccataatt ttttcccata gttttgcagt actagtactt ccatgtggta
    20761 cttctctacg ttttatagtg ttaccagaat catcttttct accagcatca tctccaatat
    20821 aagttgcacc aacataataa ggagtgtaac cgacaaacca agcatcatat gcactatttg
    20881 tagtacctgt tttacctgct acaggcattc cctttggaag tgtagcaaca ccaccagtac
    20941 cttcagtaat tacgctttct aacatatctg taacaacata agctacttca gggtctacaa
    21001 ctttatgttc ttcaggagca tttttaacta ataattgacc atcaaaggta gttatagtag
    21061 taaaaataga aggttctaca taaataccgt gatttgccaa tgtaccataa gcagcagcca
    21121 tttgaagtgg agtaatacca ttcgccatac cacctagtgt caatgatggg aattttctat
    21181 cacttgcttc agatgaacct gagtgattat tctttaaagt tgttatacca aagttcttta
    21241 agtaatccat cattatatct acacattcat cataagagtc tccaagcatt tcagcagttt
    21301 tgacagctat cgtgtttgaa gatttagcaa gtgctttacg taaactcata gaaccatgac
    21361 cagcagtagt agttcttgga ttccatttat tattttcttc aaacttatat cctcctcgag
    21421 aatcacttag agcagttgct tgtgttattt ttagagtatc aatagctggc gtatatattg
    21481 ctaaaggttt tatagaagaa cctggctgat gagggttagt agcacgattt aaagtttttc
    21541 taccacttat atttcttcct ccagctagtg ctcttatttc accattttta taatctaaga
    21601 ttaccattgc agcttgcggt tggctaactc catcaggacc gaccatatgt cctgggaaat
    21661 tgctatttct atcaaattct tcttctaaag catcttgcat tttagggtct atagttgtgt
    21721 ttacaattag accaccattg tagaataagt tttgagcttc atcatttgta tgtccttgtt
    21781 ccattaaagc atttataact tcactttcga taaggtcttc tacagatgaa gaaactttat
    21841 ctgatgattg aggcaatttt atttctattt tagctttgat tgcttcatca tattcacttt
    21901 gttttatata tttcaattct aacattttct ttaaaacaat ttcttgtctt tttttagctt
    21961 caggattact tacagccttt ctaacaacta atgtacctgc ttttaattgt ctataagtat
    22021 cattagatat aagctcccaa gattttattt tttcaatcat atcaaagtcc acttgagtag
    22081 ggtcatctaa atcatcatca gttgtgttaa caaaaaataa taatttattc tctaaatcct
    22141 ccttagtttc atttccctct aacttagaag ttttataggc tgaaaatctt gatggatttt
    22201 tagttgaacc agcaagaagt gctgactctg ctagagtaag gtcagctgca gacttatcaa
    22261 aataaccacg tgcaccagcc tcagcacctg ctagacctct accaacgaag aagttattta
    22321 aataagtttc tagtatttta tctttactta ctgttttact catctcatgt gcatagtaaa
    22381 tatcctttat tttacgaggt atagtttgct gttcagttgt taacagcatt ttggatacct
    22441 gcataggaat agtactacca ccttgcttag tacctgtaag ggtctttaat actgacctaa
    22501 ataaaccttt aatatcgaca cccttatgct cataaaaacg ctcatcttct attgcaatta
    22561 cagcatgttg aagataaggg gaaatcttat ctaatggaac gggtgtcttt ttatttacac
    22621 ttggagctgt agataatgtt tttccattag cgtatttaat agtagttgtt tggttcgtct
    22681 gtttatctaa aacagcttct gtaactggag ttacatctct tagtgacgca aatactagac
    22741 cagcagtacc tgctgtacca acaactagta aaactaaaaa tactatccca aatactctta
    22801 gttttttaaa tttatcgctt tttttagatt ttttcttgtt ttttgttgaa cgagtcttgt
    22861 tagctgaagt tctattaatt ggtttatttg tattaccaga tgagctaact ttttttctcc
    22921 tgattttatt tccattttta tcattatcgt tattcataag attttaacct ccttacttaa
    22981 tgcaatatta taacacaaat aggagtagtt ttgtaattaa tagaaaaaat gaatttgcta
    23041 taatattctg tacattgtat atgtataaac gtaatatatt aaaaagtcta tatttttatt
    23101 ttatttattt ttgacaaata ttataaaaat tatgccaaag ctacatataa ataaatagga
    23161 ggggataatt ttgaatagaa tagtagatag aaaaacaaaa aatgaattta gaaaaatcat
    23221 agctattttt ttagtaattc ttttcttgtc tgtatttata ggcagtttta tatatataga
    23281 taaaacttta agaccgacaa taacagtttt agcagagact aaagctcttg aactagcaaa
    23341 taggtcgata aataaagctg ttgctgagat ggtagaagga aaaataaatt atgaagattt
    23401 aatggatata caacttgata ataatggtaa aataactatg atacaagcaa acactataat
    23461 gatgaatgaa attgcatctg caatagcttt agaaatacaa gatgaattaa aaaaggataa
    23521 gacagcaagt tcttacatac ctataggaac agcattagga agtcctatat tagctaaata
    23581 cggtcctaaa cttgaagtat ctattgaacc tataggaaca gtatcagtaa actttaaaac
    23641 ggaatttgag tcttcaggta taaatcaaac tagacataga atatatttag aagctcaaac
    23701 acaagttaaa gtagtaatac cacttataac ttcaacaaaa caaattaaag ctcaaatacc
    23761 tatttgtgaa actataatag taggtgatgt tccagaaagt tatgtaaata ttccagaaaa
    23821 aaatctagga aatgttttac ctaacactgg aaagaatacc aacaagtaat gtaaagttgt
    23881 atatttttaa ataaattcaa aataatagtt tataaataaa atttttggaa ataatattaa
    23941 tataatttta ataaaaattt atattttata ctatgtaaaa tatctaatat atttggtctg
    24001 taggttaaat aaaagtacct ttagaccaaa tatattatta ataacttaat aacatcttaa
    24061 aacttattta tttatattat ttacaacatc catttaataa atacaccata acctacagct
    24121 gggtcgtttt caattgcatg tgacactgct ccgattattt tattatcttg aactattgga
    24181 gtaccactca taccttgtac aataccacca gtttgagcta aaagcttttt atctgtaatt
    24241 ttaattttaa aacttttact ttctggatgt ttttggtttt ctatatctat aatttcaata
    24301 ttatattttt tacacttatt aaagttatct tgtaaaatta tttgagcttt tcctaattta
    24361 acttcatcta aagatgctac tttatatttt tttaacttgg aaatatcaaa gttattaatt
    24421 tgacctctta ttccaaaatc agtattttct gtaaagctac caataatatt ttctcgtttt
    24481 gcatttatac atccaacact acctttataa gatttttcta tattaaggtg cttagttgta
    24541 gaaattgaac ctgttttaat aggtattttt cttgcattac caacacttat tggatgacct
    24601 acagctccaa actctgatgt atctggattg atatacgtta aagtagcaaa tccagaaagt
    24661 aaattgttaa aactaatttt ttctaatatg tgtttggtag ttttcattgt tataagttgt
    24721 ccacctctat ttaataaaat agatacttgt ttttcttctg gtaaagcatt taaggtattg
    24781 gcaaagtcac tatatccatc aacttcagca ttatttacct ttactatagc atcacccaat
    24841 ctaaatggag atgcttctcc aggatttcta actatgatat tttttaattc tgcgtcaatt
    24901 tgaagtacgt ttccaattgg tattaaatat tcaggttcat ttttttgtaa attttgtgca
    24961 taaattaaat tatttgagaa aaaatataat aaaaataaaa atgttaaaac aattgtaaat
    25021 tttgacttag ctaagttggt ttttttactt aaagtattat ttttaaaatg aaaattttta
    25081 agttgcataa aacacctctt tcttattaaa ttattttaat aatagaattg aagttttctt
    25141 gctgcttcta tattatgttg tgcaagaatc atgttttgat gcttggaaaa
//
LOCUS       DAEHWM010000055        25018 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.056, whole genome shotgun sequence.
ACCESSION   DAEHWM010000055 DAEHWM010000000
VERSION     DAEHWM010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 25018)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25018)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25018
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.056"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            59..1915
                     /locus_tag="KNP36_002282"
     CDS             59..1915
                     /locus_tag="KNP36_002282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBF0874148.1"
                     /translation="MDTHNKYVNFIKNIPVPFLYCRIVKRQEDIEYRVEYISKGMGKV
                     LQLEEGICDKNILDVLPVFKSKKYFKELFSNEVDCIKRYIPTLKNWINIKKQIIGDSY
                     IILYFGKIVFDYRQIIDSFDKKEKVAYIKDEEGTYIDCSENLIPILNNNIKTTKDIFG
                     KNDIEVWGENTGKLFRDDYREGVSSKKRFLQNLFEYEETFFMVEKYFLYDEDELLGTI
                     GIVDNIIYSGYSNRNYNSKDLMKMIEHSIPENMFYKDVYGNYIGFNSGFLNLACMNKE
                     ELLGKNSYKISEEEALIDKIFESDKGVVENKKVVTFELNISMNDENKCIEITKRPFFD
                     SYGSVIGIIGTARDISRRKRLEEEMDKTRMEFFANLSHELRTPINLISSSLQVIEKKE
                     ADLIESNDTLKRNLGIIKQNGNRILRLVNNVIDFTKMQSGYLDFKPEESDIIAFIEEI
                     CMSVADFASQNNIQLTFDTEIEEFSMLFDSEKLERIILNLLSNGIKYNKKDGKINIFL
                     YVKDNVFNMKISDSGIGIPKEKIDKIFNRFEQIDNELSYRVKGSGIGLSLVKSLVELH
                     EGSISLKSQLGIGSEFIVSLPVRSKNNIEKYNHKREISNELSKKLEIEFSDL"
     misc_binding    1998..2238
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     misc_binding    2304..2539
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2624..3841
                     /locus_tag="KNP36_002283"
     CDS             2624..3841
                     /locus_tag="KNP36_002283"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HBF0874149.1"
                     /translation="MENKVKIGVLGYGVVGSGLIDIIDNNKEKRNIEIVGILVNNLEK
                     HKDKKYSNIITNNIDDIFNKDIDILVEVMGGLEPSLSYIKKALNNKIHVVTANKDLLA
                     ECGDELAKLASENKVSIKFEASVAGGIPVLKPIIESLEGNNIDSINAILNGTTNFILS
                     KMYDENLSYDMALRQAQELGFAEANPESDVLGYDAARKLSILSTLAYDNRVYWKDVYL
                     EGITDIDEKDIEYAKKLNCKIKLIGQSKYENDKVSAFVRPVLVEKDNILARIDNEFNA
                     VIVNGDSVGEVSFVGKGAGSLATGSAVYSDVIDIIDNRVSSIDSFTKDKIQVNKIVRE
                     KCGALLRFKKCNKDEILNIVENCLVKFDILNDDDELAIMVYADSEYEINNSLCLIKDK
                     GYCEKMNKMLKIS"
     gene            3958..4440
                     /gene="cdeM"
                     /locus_tag="KNP36_002284"
     CDS             3958..4440
                     /gene="cdeM"
                     /locus_tag="KNP36_002284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exosporium morphogenetic protein CdeM"
                     /protein_id="HBF0874150.1"
                     /translation="MENKKCYSEDWYERGESTAKWFQNDREEYEREAYDEDRERRGSN
                     CGCSDSGENRPRNCERFRREAEIREREAREAFCESSEKKKEALAYECEARKLWEEAEK
                     YWDEYSKYNYKGIEYLAEAARLFDEGMECEARRNGNNGGNNNNCCHKCHKCNCNCCRK
                     "
     gene            4704..5969
                     /gene="hisD"
                     /locus_tag="KNP36_002285"
     CDS             4704..5969
                     /gene="hisD"
                     /locus_tag="KNP36_002285"
                     /EC_number="1.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol dehydrogenase"
                     /protein_id="HBF0874151.1"
                     /translation="MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKF
                     DRNTRDEFRITKEEIKEAYKHVDDEFINNLKIAAKNIREFAKAQKLSFENPFEKEIYP
                     GVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKIN
                     PKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQ
                     VGIDFVAGPSEVLIIADETSNPVYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNI
                     ESMLKDLPTKDIAYSSWENNGEIILVDDMEEAIKISNFYAPEHLEVAVNEYNDICDRL
                     TNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVWVGTFIKTCTKQIFNEKAI
                     QSLAPVAEKLAKEEGLYAHAKAAEVRFKK"
     gene            complement(6172..6924)
                     /locus_tag="KNP36_002286"
     CDS             complement(6172..6924)
                     /locus_tag="KNP36_002286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0874152.1"
                     /translation="MSYFQYQGNSCFYKEYGQGKPIIFLHGNTGSSNMFKALVPLYAE
                     NFRCILIDFLGNGQSDRVSQFSPDIWHDEALQTIALIEHLNCGKVGLIGTSGGAWAAV
                     NTGLERPDLVEAIIADSFDGRTLNDNFIDNLITGREKSKQDIQARKFYEWCHGKDWEN
                     VVNLDTKALLQCANEKRPLFHKELCKLEMPILFTGSKEDEMCRHNLEEEYKQMATFIS
                     KASIYIFSQGGHPAILTNADEFAQLAKVFFKY"
     gene            complement(7042..7311)
                     /locus_tag="KNP36_002287"
     CDS             complement(7042..7311)
                     /locus_tag="KNP36_002287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874153.1"
                     /translation="MSYQNSIDLLPKELIEQVQEYIDGKVIYIPKKQEHKKHWGENTN
                     TKQVLASRNSQICINFQNGMSIKQLSEKYFLTEKSIQRILKQQNL"
     gene            7786..8880
                     /locus_tag="KNP36_002288"
     CDS             7786..8880
                     /locus_tag="KNP36_002288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBF0874154.1"
                     /translation="MKNIVGKPQTIKKVNEDLIKNIIKNEGPITKPEISSITELSLAT
                     VNKIVEQLALKNEVKVSGLSESTGGRRAQLFEINANLEHIIALYYYRNCCIGVVANLL
                     GEIIYQEEFNIRMDTYENVNQDTFFVIDTLIKKEKGNNIRAIGIGVPGVVKKGVVKNI
                     PTIKSWEGINLENLIKSKYNTKVFIENDTNITTIGIYQKQYKDKYKNMALMYLEDGIG
                     SGIVINGELYLGSTNFAGELSYLNIEFGKYNSNNLNLEDYIMSLRKRYLESKDNKFKK
                     EILSIISNFIRTLVCVLNPQAMIIQCSILTKSDMEFIEKDVSNNVGEENFPKLIKVDS
                     LREGSINGVISMCLKETDYQYSLSNKKGGY"
     gene            8882..9832
                     /locus_tag="KNP36_002289"
     CDS             8882..9832
                     /locus_tag="KNP36_002289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine kinase"
                     /protein_id="HBF0874155.1"
                     /translation="MKYLVSIDGGGTKTKFCVSDLDGNILKEHTTGSTNYKSVGIKKT
                     YENINNGFKKILKDLYIDYDDIEYTVFGISGCDSPNDYKIIMDEILKIGINKEKIYLA
                     NDAVLAFYAQADSPGLVIVAGTGSIILGIKEDGEIYRVGGWGYNFSDLGSGYDIGRKL
                     LKKVLLYCDECHEYSDLFSCVLDFFGANSFEQLAYMITDINDNVEIANLASLVIDCAE
                     QGDKLAIEILRESSTELSKLAQVILRKISNPMKMDKSEINIVLSGGTLNKTVYAQMLM
                     NNLKTENTDKNLKFISQENQPVYGGIRLAMALANRRVKHG"
     gene            9825..11009
                     /locus_tag="KNP36_002290"
     CDS             9825..11009
                     /locus_tag="KNP36_002290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874156.1"
                     /translation="MDRKKVIVQIFTGGFKAKEIKFNDIKCKLLELLDCIDIEKVIMG
                     WSVDEELYVETKKLLNKYNVELYLWLPCFSEIGLLEKSNLLIDYMGKEVKGYALQEDE
                     NFEFYCPNNKENIKNIKKIYSTYFSDIKFDGIFLDKIRYGSFSNKLNGVFNCFCKDCL
                     NIYKKNNIDKESLMREMNNVSKGVIDNEDTPFGITEYINGKYKFKNKIWEDFFETKNQ
                     NIYKALLEISSYFKSKGLKIGIDAFSPFISYFTGQDLEKLQEVADFIKPMMYRTTKAP
                     AGLPFEFERFIDESIHKNKEIGKRNFLDILGIKEYEGDVYPIEFVLEEIDFMTRNLNK
                     DIYVGVEINKKEIISPVTPKYISENISNINKTTVKGYVLSWDLLSAPKENIDEIIKWF
                     RN"
     gene            11022..12518
                     /locus_tag="KNP36_002291"
     CDS             11022..12518
                     /locus_tag="KNP36_002291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="HBF0874157.1"
                     /translation="MSKILEIQQIYKSFGKVDVLKGINFELEKGEVRALLGANGAGKS
                     TLIKILGGVHSQTKGKVILTGNEIMFKNPHHSKENGISIIYQELSLIPTLTVLENIFL
                     GREILKGSVFLNKKDMLEEYMKICEDFDFNIDPHIVVSNLSVANQQMVEIMKAVSCNS
                     EIIIMDEPTTSLTNNEKDGLFKIISRLKSKGKTIVYISHILEEVFKVCDSASIMKNGI
                     MIGTYDVEDLTKLKITQLMTGNDNHKLIEKKDYTFAKYEEPPVLEVKNISWSNKIKNV
                     SFKVYRGEVVGLAGLVGSRRTEIINLIFGIDNKDSGDIFINGKKVDITSPKVAIKNKI
                     GLIPEDRKNLGLILEQAIYTNSSSVQIDKFKKFLFIDRNKEIEFSKKGVKELGIKVSD
                     VKQEVKELSGGNQQKVVVSKWLEKDLDLIIYDEPTKGIDIAAKEDIFNTIKEFSSKGI
                     GVIFISSDLEEVIRVSDRILVTREGSIVDDLKNENIQVQDIMNSIFNV"
     gene            12541..13491
                     /locus_tag="KNP36_002292"
     CDS             12541..13491
                     /locus_tag="KNP36_002292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874158.1"
                     /translation="MKKAFEKLNLRDYGVLLGFLALCIAISIATPSFLGKQNILNLLR
                     QSSIIGIISAGMTFVIISGNFDISVGAVAALAGAITMKFATGGTNLFASMFLGVAICA
                     VIGLINGIVVAKINVPSLIATMAMVTIVRGLLLMLTGGYPITENIPILDYIGNGYLFN
                     IPIPVVIFFIVVLASFIVLNKTKFGRYVYSVGGNQEASKLNGINVDSHKVKVFIINAV
                     LAGIAGIVLTGRLGTATAIAGEGYDMDAIASVVIGGTSVAGGSGSVLKTVIGVLLMSV
                     INNSFNLLGIDVYFQYIFKGLIILAAVGFDSYSKKKLASR"
     gene            13512..14474
                     /locus_tag="KNP36_002293"
     CDS             13512..14474
                     /locus_tag="KNP36_002293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HBF0874159.1"
                     /translation="MKKLMKHLALLLSLVMIFGLVGCSNGGDKEKNGEKKIAVLLPGS
                     TGYFVATKQGIDAKSKELGVSVEYADAQWDASKQLSQAEDFMAKGVDMIALCGVDSAV
                     SERIVKAANDSDVPIVAFTNSIGSNPTGEFKGLVTYIGQNEEETGALTGKIAKNLLGE
                     TGGKAVLIEGVPGTTPQVLRKKGLEKELKDSNIEIVYNQTSNWEKEQALKVTEDLIQK
                     KTDFNVIICQDDNSATGAGQALKDAGLKDKVKVIGLGGSKDGLKAITDGLIDGTTYMS
                     AVEEGGLVIEKASKFLKGEKIEPVTQIKQVEVNKDNISEFKGEW"
     gene            14846..15478
                     /locus_tag="KNP36_002294"
     CDS             14846..15478
                     /locus_tag="KNP36_002294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBF0874160.1"
                     /translation="MARRLFLERIGLIFLGSAILAFGVYNFYYLNNITEGGVLGILLL
                     LKNLFNIQPAIANVVIDGLLLLVGYKFFGKKFLIYSIVASITFSVLYDLFEAIGPLVP
                     QSQNMLLSTILAGVTVGTGVGIVVKAGCASGGDDALALVISKTTSLNIGQVYLATDVI
                     VLLLSLFYLSAFDIFYSLIAVTISGKVIDFIYYHGKSLDMDISNDIVPEC"
     gene            15889..15981
                     /gene="kdpF"
                     /locus_tag="KNP36_002295"
     CDS             15889..15981
                     /gene="kdpF"
                     /locus_tag="KNP36_002295"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: protein motif:HMM:TIGR02115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="K(+)-transporting ATPase subunit F"
                     /protein_id="HBF0874161.1"
                     /translation="MEGLPMWFLAVVIIMLIIYLVYALINPEKF"
     gene            16022..17704
                     /gene="kdpA"
                     /locus_tag="KNP36_002296"
     CDS             16022..17704
                     /gene="kdpA"
                     /locus_tag="KNP36_002296"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015391009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium-transporting ATPase subunit KdpA"
                     /protein_id="HBF0874162.1"
                     /translation="MFMVQIVIVLAIFMILVIPMGKYLYHIATNQKTFGDRLFDKVDN
                     FIYKVCSIDKKKEMNWKQYALALLFTNAVMVFIGYIILRTQSMHIFNPSGIKSMEQGL
                     SFNTIISFMTNTNLQHYSGESGLSYFSQMTVIIYMMFTSAATGYAAAMAFVRGLVGKK
                     KTLGNFYVDLIRITTRVLLPGALIIGLILVTQGVPQTFAGTETVTTIEGKLQDIARGP
                     VAALESIKHLGTNGGGFFGSNSSHPFENPTIISNIVEILSMMILPGACVVAFGHMIKN
                     KKQGWVVFGAMSIIFLIGLVVCFKAESAGNPILSQLGLNQSMGSMEGKEVRFGIAQSS
                     LFTTVTTSFTTGTVNNMHDTLTPLGGLVPLLNMMLNVVFGGKGVGLMNMLMYAIIAVF
                     LCGLMVGRTPEFLTKKIEGKEMKLIALLIILHPLLILMFSGLSVAIPAGLEGISNPGF
                     HGLSQVLYEFASSAANNGSGFEGLGDNTMFWNITTGVVMFFGRYVSIIVLLAISSLLA
                     SKKAVNESIGTLRTDNFTFTIVLVLVVLIVGALTFFPALALGPISEHLVLWH"
     gene            17729..19786
                     /gene="kdpB"
                     /locus_tag="KNP36_002297"
     CDS             17729..19786
                     /gene="kdpB"
                     /locus_tag="KNP36_002297"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010966942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium-transporting ATPase subunit KdpB"
                     /protein_id="HBF0874163.1"
                     /translation="METKKTKFITKDIFKTSIIEAFKKLNPKYMMKNPVMFVVEIGFI
                     VTLILTIVPSLFGDEGNNLRAYNGIVTIILFITVLFANFAEAVAEGRGKAQADTLKKT
                     RKDTVARVIDTLGNEKMISASELKLGDIVLVNAGEVIPNDGEVIEGIASVDESAITGE
                     SAPVMRESGGDFASVTGGTTVVSDWLKIRITTKPGESFLDKMIALVEGASRQKTPNEI
                     ALNTLLVGLTLIFMVVLISLYPMANYAGVKIPISTMIALLVCLIPTTIGGLLSAIGIA
                     GMDRVTRFNVIAMSGKAVEACGDVDTMILDKTGTITYGNRLASEFIAVGNADSKDLIN
                     YSVMCSLKDDTPEGKSIVDLGMKLGSTGKTKEAEEAEFVEFSAQTRMSGINLADGRAI
                     RKGAYDSIIKRVKESGGTVPEDLEENVNRVAKLGGTPLVVCVDNEIYGIIYLKDTVKS
                     GLVERFARLREIGIKTIMCTGDNPLTAATIAREAGVDGFIAECKPEDKIDAIKKEQLE
                     GKIVAMTGDGTNDAPALAQADVGLAMNSGTTSAKEAANMVDLDSDPTKILEVVEIGKQ
                     LLITRGALTTFSIANDVAKYFAIIPAIFTLAIPQMEILNVMKLSTSFSAILSALIFNA
                     IIIPCLIPLAMKGVKYRPMKSQAMLMRNMLIFGLGGVIVPFLGIKLIDLLITPLVMVL
                     NLG"
     gene            19805..20431
                     /locus_tag="KNP36_002298"
     CDS             19805..20431
                     /locus_tag="KNP36_002298"
                     /EC_number="7.2.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="K(+)-transporting ATPase subunit C"
                     /protein_id="HBF0874164.1"
                     /translation="MKTLKPALLVSIVLLVVCGLVYPLVLTGVSQVAFKDKANGSMIE
                     VNGVKVGSELIGQSFTDARFFKGRVSSVNYNTYTKEDLVPDKDGNTSYGGVSSGSFNY
                     GATNPELHDRVQKDIEKFLKDNPTVKREDIPTDLLTASGSGLDPNISPASAKIQIPAI
                     AKASGISESKLQKIVDDNTSKKLFGVLGEDRVNVLKVNVEVAKILGLI"
     gene            20668..21576
                     /gene="cysK"
                     /locus_tag="KNP36_002299"
     CDS             20668..21576
                     /gene="cysK"
                     /locus_tag="KNP36_002299"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HBF0874165.1"
                     /translation="MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIK
                     DRAVYEMLEGLEQRGELKKGDVLVEATSGNTGIALSMIGKLKGYEVVIVMPETMSVER
                     RDLMKAYGANLVLTDGKAGMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAV
                     EIMNDVKDLDIFVCGVGTGGTLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHK
                     IQGIGANFVPENYDSSVVDEVILVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEM
                     AKKYPDKKIVTVAPDGVDKYMSMGIF"
     gene            21603..22193
                     /gene="cysE"
                     /locus_tag="KNP36_002300"
     CDS             21603..22193
                     /gene="cysE"
                     /locus_tag="KNP36_002300"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HBF0874166.1"
                     /translation="MFKKINKDIEYIMKNDPAARSKIEVFLLYPSVHAMIMHRMAHAL
                     YKKKKLFTARLISQISRFMTGIEIHPGAKMGEGILIDHGMGVVIGETAEVGNRVTIYQ
                     GATLGATGKDTGKRHPTVGDDVLIGAGTKILGPLNIGSNSKIGANSVVVKDVPNGATV
                     VGIPAKIVKIRNLEPVKKNKKEVSYEYDELDNVYYI"
     gene            22353..22541
                     /locus_tag="KNP36_002301"
     CDS             22353..22541
                     /locus_tag="KNP36_002301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HBF0874167.1"
                     /translation="MKANVNQDTCIGCGLCPSICPEVFDMKDDGKSHVIVDEVPSDAE
                     ESAAEARESCPVDAIDVH"
     gene            complement(22595..23464)
                     /locus_tag="KNP36_002302"
     CDS             complement(22595..23464)
                     /locus_tag="KNP36_002302"
                     /EC_number="3.4.11.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HBF0874168.1"
                     /translation="MKLNRNDSCWCGSTKKYKKCHMDMDNKIDSFAKLGHIVPTHDII
                     KNESQIEEIKKSAVINTKILDYISDKIEIGMSTEDINKLVHDFTLQNGAIPAPLDYNG
                     FPKSVCTSVNNEVCHGIPSKDIILKDGDIINVDVSTIFNGYYSDASRMFMIGNVNENA
                     KKLVQVTKECVQKGLEVAKPWGFLGDIGDAINSYAKKNGYSVVREIGGHGVGLSFHED
                     PFVSYVSKKGTEMLLVPGMIFTIEPMVNEGTHEIFVDEENNWTIYTKDGKLSAQWECM
                     VLVTETGVEILTE"
     gene            complement(23661..24905)
                     /locus_tag="KNP36_002303"
     CDS             complement(23661..24905)
                     /locus_tag="KNP36_002303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874169.1"
                     /translation="MENNLNTAKRNNTELLQNDSLKVNLQIGVDFTLLSKSLKAFYKK
                     EKDFYCIALAPCNVSSEKANRKISIYDMIKEINILIESITDKNELLSEELFTNNLSEF
                     YDESLDEIYIDLKQAYLYIKKNTDGLNIEDSIEYVFDVDISNDIKAKENPLINFNSLS
                     LVVWSGETKHILQQMNILDLEDIHSYSIENNTNITIYENNTLQYKFDEESENIKDSSI
                     DIIEQMLILPDDLNYDKDEVENMKNRLAKINIKYLQTLKEKDIKIKLINSNLTDEPEF
                     SDLKYQLPPCWVRSGKTWKDVPGIYRNNSIVAKIGYSNPSYANVHSSKNLELHETAHA
                     IDKNVLNKKSNSEEFMEVFAQERYKLYDPKQVAHAYISKFIEEFFAESFVHYYLDEDS
                     KNTLKENCPLTYDFLEKLELNY"
BASE COUNT         9634 a         2674 c         4507 g         8203 t
ORIGIN      
        1 tcatataatt aattaagtag tattattata aataacattg aaaggtagtg gttagaatat
       61 ggatacccat aataaatatg taaattttat aaaaaatata cctgtacctt ttttatattg
      121 tagaattgta aagagacaag aagatataga atatcgagta gaatatataa gtaagggtat
      181 gggcaaagta ttacaattag aagaaggtat ttgtgataaa aatatactag atgtattgcc
      241 tgtatttaag tctaaaaaat atttcaaaga gttgttctca aatgaagtgg attgtataaa
      301 aaggtacatt ccgacactta aaaattggat aaatataaaa aaacagataa taggggattc
      361 atacataatt ttgtattttg gtaaaattgt atttgattat agacagataa tcgattcctt
      421 tgataaaaag gaaaaagtag cttatattaa agacgaagaa ggcacatata tagattgcag
      481 tgaaaattta ataccaatat taaataacaa cattaaaaca acgaaagata tctttggtaa
      541 aaatgatata gaagtatggg gagagaatac aggaaaatta tttagagatg attatagaga
      601 aggagtatct agtaaaaaaa gatttttaca aaatcttttt gaatatgaag aaacattttt
      661 tatggttgaa aaatattttt tgtatgatga agacgaactt ttaggtacta tagggatagt
      721 agacaatata atatatagtg gttacagtaa tagaaattat aactcaaaag atttaatgaa
      781 gatgatagaa cactcaattc cagagaatat gttttataaa gatgtgtatg gaaattatat
      841 tggatttaat tcaggttttt tgaatttagc ttgtatgaat aaagaagaat tattagggaa
      901 gaatagttat aaaatatcag aagaagaagc tttaatagat aagatatttg aaagtgataa
      961 gggtgtagtt gaaaataaaa aagtagttac atttgagtta aatataagta tgaatgatga
     1021 aaacaagtgt attgagatta caaaaaggcc gttttttgat agctatggaa gtgttattgg
     1081 aataattgga acagcaaggg atataagtag aagaaaaaga ttagaagagg aaatggataa
     1141 aactaggatg gaattttttg caaatttatc ccatgaactt agaacgccta taaacttaat
     1201 atcatcttca ttacaagtga tagaaaaaaa agaagcagat ttaatagaat caaatgatac
     1261 tttaaaaaga aatttaggta taataaaaca aaatggaaat agaatattaa gattagtaaa
     1321 taatgttata gattttacaa aaatgcaatc aggatattta gattttaaac cagaagaatc
     1381 tgatataatt gcatttatag aggagatatg tatgtctgta gctgattttg caagccaaaa
     1441 taatatacaa cttacatttg atacagaaat agaagaattt tcaatgttat ttgattcaga
     1501 aaaattggaa agaataatat taaatttact ttctaatgga attaagtaca ataagaaaga
     1561 tggaaaaata aatatatttt tatatgtgaa agataatgta tttaatatga aaatatctga
     1621 tagtggaata ggaataccaa aagaaaaaat agataaaata tttaataggt ttgaacagat
     1681 tgacaatgaa ctttcttaca gagttaaagg aagtggtatt ggactttcat tagtgaaatc
     1741 tttggttgag ttgcatgagg gaagtatatc tttaaaaagt caacttggta ttggaagtga
     1801 atttatagtt tcattgcctg ttagaagtaa aaataatatt gaaaaatata atcataaaag
     1861 agaaatcagc aatgaattaa gtaaaaaatt agaaatagag ttctcggatt tataagttta
     1921 aatataaaaa ataaaatttt aaaaaagtat tgacaattga tttagaaggg tttaaaataa
     1981 attacaacat aataaataaa aaggcgatga ataggaagag taaatctaat tcgattacca
     2041 gagagaagag tccgttggct ggaagacttt ttaaattaga gggattgaaa actacctagg
     2101 agctactttc tgaagtcatc tgcattagta gattttagta agaatagtcg ttagctgcgt
     2161 taaagtgtaa agtgagtttt catgacatat gaaaactaaa ttaggtggaa ccgcgggaat
     2221 aatactctcg tccttatgtt ataaggatga gagttttttg ttatttaaaa atataaacag
     2281 taatcataat aattatagaa aatataaaag caatgaatag gaagagtaaa tttaattcga
     2341 ctatcagaga ggaaagttca caggctgaaa gactttctaa gtttgagaaa ttgaaaacta
     2401 cctaggagct gtggtctgaa gttactttaa aaagttttag taagactaac cgttaactgc
     2461 gttaaagtgt aaagtggatt ttatcaataa atgataaaat caaattgggt ggaaccgcga
     2521 gtatagactc gtccctttat atagggatga gtctattttt attgcaataa aagattgaaa
     2581 ataaaaaaaa atcggaaaat tataaattta ggaggaaaat aaaatggaga ataaagtgaa
     2641 aattggagta ctaggatatg gagttgtagg aagtggactt atagatataa tagataataa
     2701 taaagaaaaa agaaatatag aaatagttgg aattttagtt aataatttgg aaaaacataa
     2761 ggataaaaaa tattctaata taataactaa taatatagat gatatattta ataaagatat
     2821 agatatactt gttgaagtca tgggtggttt agaaccatca ttatcttata taaaaaaagc
     2881 attaaacaat aaaattcatg ttgttacagc aaataaagat ttgttagctg aatgtggaga
     2941 tgagcttgca aaattagcaa gtgaaaataa agtaagtatt aaatttgaag cttcagttgc
     3001 aggaggtata ccagtattaa aaccaataat agaatcacta gaaggaaata atatagatag
     3061 tataaatgca attttaaatg gaactactaa ttttatatta tctaaaatgt atgatgagaa
     3121 tctatcttat gatatggcat taagacaagc acaagaatta ggttttgctg aagcaaatcc
     3181 agagtcagat gtattagggt atgatgctgc tagaaaacta tcaatattat caactctagc
     3241 ttatgacaat agagtatatt ggaaagatgt gtatttagaa ggaattacag atatagatga
     3301 aaaagatatt gaatatgcaa aaaaattaaa ttgtaaaata aaattgattg gtcaaagtaa
     3361 gtatgaaaat gataaagtaa gtgcttttgt tagacctgtt ttagtagaaa aagataatat
     3421 ccttgctaga atagacaatg agttcaatgc tgtcatagtg aatggagatt cagtaggaga
     3481 agtttctttt gtaggtaaag gagctggaag tttagcaaca ggaagtgcgg tttattcaga
     3541 tgttatagat ataatagata atagagtttc aagtatagat tcttttacta aagataaaat
     3601 acaagttaat aaaatagtta gagaaaagtg tggagcactt cttagattta aaaaatgtaa
     3661 taaagatgaa attctaaata tagttgagaa ttgtttagta aaattcgata ttttaaatga
     3721 tgatgatgaa cttgctatta tggtttatgc tgattctgaa tatgaaataa acaacagttt
     3781 atgtctaata aaagataaag gatactgcga aaaaatgaat aaaatgttga aaataagtta
     3841 aaaaagaaaa aatataagtt tatatgtaac atattttgac gattttaata ctatatagta
     3901 tgagatgaaa caaaacatct cataaaaaaa ttaaaattaa agggagagat atgttatatg
     3961 gaaaataaaa aatgttattc agaagattgg tatgaaagag gagaatctac agctaaatgg
     4021 ttccaaaatg atagagaaga atatgaaaga gaagcatatg atgaagatag agaaagaaga
     4081 ggttcaaact gtggatgttc agattcagga gaaaatagac ctagaaactg tgaaagattt
     4141 agaagagaag ctgagataag agaaagagaa gcaagagaag cattctgtga atcttcagag
     4201 aaaaagaaag aggcattagc atatgaatgt gaagctagaa aattatggga agaagcagaa
     4261 aaatactggg atgaatattc aaaatacaac tataaaggaa tcgaatattt agcagaagct
     4321 gctagattat ttgatgaagg tatggaatgt gaagctagaa gaaatggaaa taatggagga
     4381 aacaataata attgttgcca taaatgccat aaatgtaatt gtaactgctg tagaaaataa
     4441 aaaaattaat tgacaaatca atagttaaaa tatatcatat tatgtataat aaagagaaaa
     4501 ttcagaaaaa aataatgatt agaagaaata taagtatatt tattagacaa atagtgctca
     4561 gttagtgagg tgagtacaat atgattaaac tcccatcctc tagcttttga tagagggtgg
     4621 gagtttttat ttatttatat atcttaaatg aggataatat tgtaaaataa atgagtatga
     4681 gattgtaaaa ttaggaggta aaaatgaaaa gtattaaaac atcaagtatg aaagaaaagg
     4741 tagatgaaaa gatattaaga gagcaagtaa gttctataat agaagatata agaaataata
     4801 aggatgttgc acttaaaaaa tataatgaga agtttgatag aaatacaaga gatgaattta
     4861 gaattactaa ggaagaaata aaggaagctt ataagcatgt agatgacgaa tttataaata
     4921 acttaaagat tgctgccaaa aatataagag aatttgctaa agctcaaaaa ctaagttttg
     4981 aaaacccttt tgaaaaagaa atttatccag gtgtaatctt aggtcaaact aatattccaa
     5041 tagagtcatg tcttgcatat gttccaggag gtcagtatcc attgttttca acagctctta
     5101 tgcttataat acctgcaaaa gtagcaggag taaaaagaat agtggcatgt tcaccaacta
     5161 tgaaaaatac tgaaaagata aatcctaaga cattggtagc tatggatata gcaggtgctg
     5221 atgaaatata tgcaactgga ggagttcaag ctatagcagc atttacatat ggaacagaaa
     5281 agattaatcc agttgacata attgtaggac caggaaataa gtttgtaact gaagctaaaa
     5341 gacaatgtta tggacaagta gggattgatt ttgtcgctgg gccaagtgaa gttcttataa
     5401 tagcggatga aacttcaaat ccagtttata ttgcagctga tttattagca caatgtgagc
     5461 atgatttaaa tgcaagagga atattattga caaatagctt ggaagtagca caaaaagttg
     5521 aaaaaaatat agaaagtatg ctaaaagatt tgccaacaaa ggacatagca tatagttcat
     5581 gggaaaataa tggagagata atattggttg atgatatgga agaagccatt aaaataagta
     5641 atttttatgc accagaacat ttagaagttg cagtaaatga gtataatgat atttgtgata
     5701 gattaactaa ctatggttct ttatttattg gaaatctttc tgctgaggtg tttggtgact
     5761 atgtttcagg taccaatcat acattaccaa cacttaaagc atcaagatat actggtggtg
     5821 tttgggttgg aacttttatc aaaacttgta caaagcagat atttaatgaa aaagctatac
     5881 aatcattagc acctgtagct gaaaagctgg caaaagaaga gggattatat gcacatgcaa
     5941 aggctgctga ggttaggttt aaaaagtagt aaaaaatttt attttggcag tcgagactta
     6001 gtattagact gagataagga aaacgctgag aacctgaata aatactatat tttgtgggtc
     6061 tcggcgcttc ttttatatct gtatataata gaataatact atctgtgtgt ttaaatacta
     6121 acttaatatt tcttttctaa ataatgttta tgaaatagtt aatattttta gttaatactt
     6181 gaaaaaaact tttgctaact gtgcaaattc atctgcattt gtcaatatag cagggtgtcc
     6241 tccctgacta aaaatgtaaa tacttgcttt tgaaataaaa gttgccattt gcttgtactc
     6301 ttcttcaaga ttatgacgac acatttcgtc ttccttactt cctgtaaata aaattggcat
     6361 ttctaattta cacaattctt tatgaaacaa agggcgtttc tcgtttgcac attgcaatag
     6421 agcttttgta tcaagattaa caacattctc ccaatctttt ccatgacacc attcatagaa
     6481 ttttcgtgct tgaatatctt gctttgattt ttcccttcca gtgattagat tatctatgaa
     6541 gttatcatta agagtacgtc catcaaagct atctgctata attgcttcaa ctaaatcggg
     6601 acgttctaat ccagtattaa cagctgccca tgctcctcca cttgttccaa ttaagccaac
     6661 tttaccacaa ttcaaatgtt caatcagtgc tattgtctgt aaggcttcat catgccatat
     6721 gtcaggagaa aattgagaaa ctctatccga ctgtccatta cctaaaaaat caattaagat
     6781 acatctaaaa ttttctgcat ataatggcac aagtgcttta aacatattag aagaaccagt
     6841 attaccatgc aggaaaatta tcggtttacc ttgtccatat tctttataaa aacaagaatt
     6901 accttgatac tgaaaatatg acatatattt tcctcctttt tatttgttaa gttaattata
     6961 acaatatagg tatgaatgaa aaacctcatg ttctttctta gaataaaaat gtgccacgca
     7021 taaaacgtga cacatttcta attataaatt ttgctgttta agtattcttt gtatgctttt
     7081 ctctgtcaaa aagtatttct ctgataactg cttgatactc attccatttt ggaaatttat
     7141 acagatttga gaattacgag aagctaagac ttgtttggtg tttgtgtttt caccccaatg
     7201 ctttttgtgc tcttgctttt tgggaatata aatcacttta ccatctatat attcttgcac
     7261 ttgctcaatc agttctttag gcagtaagtc aatcgaattt tgatagctca ttttgcacct
     7321 cctaaataat tattctttag gattagcaaa ggctactgcc actcacaatt aaaaataaaa
     7381 ttttttatta tgtacaatag cctttgctat gcacaagttc caattcccat aaactaaata
     7441 ctcctttctg gtttgaaaaa ttcatctgaa cattgatttc gcttttaaga tagagttcaa
     7501 tgacaaattt acatttttat tatatatatt cagatagata attgcaactg tctttgtatg
     7561 aggatatttt attatagtca atactataat atgtatttat atcatcaaac taatatgaac
     7621 agttgaaagg aatatgaaca ataaaactta gtcaggaaga ataattatga agcagacaat
     7681 agagaaattt gattttaaag ttttattgaa aatttattga caaatttaac ttgtaaatat
     7741 tatactaaac ttaataaata aagtttataa agtaaggtgt tgtctatgaa aaatatagtt
     7801 ggaaaaccgc aaacgataaa aaaagtaaat gaagatttaa taaaaaacat tataaaaaat
     7861 gaaggtccta taacaaaacc agaaatttca agcattactg aattgagttt agctacagtt
     7921 aataagattg tagagcaatt agctttgaaa aatgaagtta aagtaagtgg actaagtgaa
     7981 tctactggag gaagaagagc tcaattattt gaaataaatg caaacttaga acacataata
     8041 gctttatatt attatagaaa ttgttgtata ggggtagttg ccaatttatt aggtgaaata
     8101 atttatcaag aagaatttaa tataagaatg gatacgtatg aaaacgttaa ccaagatact
     8161 ttttttgtta tagatactct aataaaaaag gaaaaaggaa acaatataag ggctattgga
     8221 attggtgtcc caggagttgt aaaaaaaggt gtagttaaaa atataccaac tataaaaagt
     8281 tgggaaggta taaatttaga aaatttaata aagagtaaat acaatactaa agtgtttata
     8341 gaaaatgata caaatattac tactattggg atttatcaaa aacagtataa agacaaatat
     8401 aaaaatatgg ctcttatgta tttagaagat ggtattggtt caggtatagt tataaatggt
     8461 gaattgtatt taggttctac aaattttgct ggagaattaa gttatctaaa tatagaattt
     8521 ggtaagtata actctaacaa cttaaatctt gaagattata ttatgagttt aagaaaaaga
     8581 tatttagaaa gtaaagataa taaatttaag aaagaaattt tatctataat atcaaacttt
     8641 ataaggactc ttgtatgtgt cctaaatcca caagctatga ttatacagtg tagtatatta
     8701 accaagagtg acatggagtt tatagaaaaa gatgtaagca ataatgttgg agaagaaaat
     8761 tttcctaaat taataaaagt agactcattg agagaaggaa gtataaatgg agtaattagt
     8821 atgtgtttaa aagaaactga ctatcaatat tccttatcta ataaaaaagg aggatattaa
     8881 tgtgaaatat ttggtttcaa tagatggagg gggaacaaaa actaaatttt gtgtaagtga
     8941 cttagatgga aacatactta aagaacatac cactggttca actaattata agtcagttgg
     9001 aattaaaaaa acatatgaaa atattaataa tggatttaaa aaaatattaa aagatttata
     9061 tatcgattat gacgatattg agtacactgt atttggtata tctggttgtg attctcctaa
     9121 tgattataag attataatgg atgaaatatt aaaaattggg attaacaaag aaaaaatata
     9181 tctggcaaat gatgcagttt tagcttttta tgcacaagct gattcccctg gcttagtaat
     9241 tgtggctggg acaggttcaa ttatactggg aattaaagaa gatggagaaa tatatagagt
     9301 tggtggatgg gggtataatt ttagtgattt gggttctgga tatgatatag ggagaaaatt
     9361 attaaagaaa gtattgcttt attgtgatga atgtcatgag tatagtgatt tatttagttg
     9421 tgtcttggac ttctttggag caaatagttt tgaacaactt gcatatatga ttactgatat
     9481 aaatgataat gttgaaatag caaacttagc ttcattagtg attgattgtg ccgaacaagg
     9541 tgataaattg gctattgaaa tattaagaga atcatcaact gaactatcta aattagctca
     9601 agtaatattg agaaaaatat ctaatccaat gaaaatggat aaaagcgaaa taaatatagt
     9661 tttgtctggt ggtacattaa ataaaactgt atatgctcaa atgttaatga ataatttaaa
     9721 aacagaaaat acagataaaa atttaaaatt tatatctcaa gaaaatcagc cagtatatgg
     9781 ggggataaga cttgctatgg cattagctaa taggagggtc aagcatggat agaaaaaagg
     9841 taatagtaca aatttttact ggaggtttta aggctaaaga aataaagttt aatgatataa
     9901 aatgtaaact actagaatta ttggactgta ttgatataga aaaggttatc atgggatgga
     9961 gtgtagatga agaattatat gtagaaacta aaaaactatt aaataaatat aatgttgaac
    10021 tatatctttg gttgccatgt ttttctgaaa taggattact tgaaaaaagt aatttactaa
    10081 ttgattatat ggggaaggaa gtcaagggct atgctttaca agaggatgaa aattttgagt
    10141 tttattgccc aaataataag gaaaatataa aaaatataaa gaaaatatat agtacttatt
    10201 ttagtgatat taaatttgat ggaatttttt tagataaaat aaggtatggt tctttttcga
    10261 ataaactaaa tggtgttttt aattgttttt gtaaagattg tttaaatata tataaaaaaa
    10321 ataatattga taaagagtcg ttaatgagag aaatgaataa tgtgtctaag ggagttatag
    10381 ataatgaaga tactccattt ggtataacag aatacattaa tggaaaatac aaatttaaaa
    10441 ataaaatatg ggaagatttt tttgaaacaa aaaatcaaaa tatatacaag gcattattag
    10501 agataagtag ttattttaaa agtaagggat tgaaaatagg tatagatgct ttttctcctt
    10561 ttatttctta ctttacaggt caagatttag aaaaattaca agaagtagca gattttataa
    10621 aaccaatgat gtatagaact acaaaagctc cagctggttt accatttgaa tttgaaaggt
    10681 ttattgatga atccatacat aagaataaag agattggaaa aagaaatttc ttagatattt
    10741 taggaattaa ggagtatgaa ggagatgtat atcctataga atttgtacta gaggaaatcg
    10801 attttatgac aagaaatctt aataaagata tatatgtagg agttgaaata aataaaaagg
    10861 aaattatatc tcctgttaca cctaagtaca taagtgaaaa tatttcaaat ataaataaga
    10921 caacagtaaa aggatatgtt ttatcttggg atttgttgtc agcaccaaaa gaaaatattg
    10981 atgaaattat aaaatggttt cggaattagt gaggtgataa agtgagtaag atattggaaa
    11041 tacaacaaat atataaaagt tttggaaagg tagatgtttt aaaagggata aattttgagt
    11101 tagaaaaggg agaagtaaga gctcttttgg gagctaatgg agcaggaaaa tctacactta
    11161 ttaaaatttt aggaggagtt cattctcaaa ctaaaggtaa agtaattttg actggtaatg
    11221 aaataatgtt taaaaatcca catcattcta aagaaaatgg tattagtata atttatcaag
    11281 aattaagctt gataccaacg cttacagtac ttgaaaatat ttttcttggt agagaaattt
    11341 taaaaggaag tgtgttttta aacaagaaag acatgcttga ggaatatatg aaaatttgtg
    11401 aggattttga ttttaatata gacccacata tagtagtttc taatttaagt gtagcaaacc
    11461 aacaaatggt tgagataatg aaagctgttt catgtaattc tgaaattatc ataatggatg
    11521 aacctacaac atcacttact aataatgaaa aagatgggct atttaaaata ataagtagac
    11581 taaagtctaa aggtaaaaca atagtctata tttctcacat attagaggaa gtttttaaag
    11641 tatgtgatag tgcaagtata atgaaaaatg gaattatgat tggaacttat gatgtagagg
    11701 atttaactaa attaaagata actcaactta tgacaggaaa tgataatcac aaacttattg
    11761 agaagaagga ttatacattt gcaaaatatg aagagccacc agtactagaa gtaaagaata
    11821 taagctggtc taacaaaata aaaaatgttt catttaaagt ttatagaggc gaagttgtag
    11881 gtcttgcagg tcttgtaggt tcaagaagaa ctgaaattat aaatttgata tttggtatag
    11941 ataataaaga tagtggagat atttttatca atggtaaaaa agtagacata acttctccta
    12001 aggttgctat aaaaaacaaa ataggattga ttcctgaaga tagaaaaaat ctaggattaa
    12061 ttttagaaca agctatatac acaaactcat catcagtaca aattgataaa ttcaagaaat
    12121 ttttgtttat agatagaaat aaagaaattg agttttctaa aaaaggtgtt aaggaattag
    12181 gaataaaagt tagtgatgta aagcaagaag taaaagagct tagtggtgga aatcaacaaa
    12241 aagtagtagt ttctaagtgg ttagagaaag atttagattt aataatatat gatgagccaa
    12301 caaagggaat agatattgct gcaaaagaag atattttcaa tacaatcaaa gaattttcaa
    12361 gtaaaggaat aggagtaata tttatatctt ctgatttaga agaagtaata agagtaagtg
    12421 atagaatttt agtaactaga gaaggttcta ttgtagatga tttaaaaaat gagaatatac
    12481 aggttcaaga tataatgaac agtatattta atgtataaaa aatgaaaatg gaggactgag
    12541 atgaagaaag cttttgagaa gttaaattta agagattatg gagtattatt aggtttttta
    12601 gctttatgta tagctataag tattgcaact ccatcatttt taggtaaaca aaatatactt
    12661 aatcttttac gacaatcttc tataattgga ataatttcag caggtatgac ttttgttata
    12721 atatctggaa actttgatat atcagttgga gcagtagcag ctcttgcagg tgctataaca
    12781 atgaaatttg cgactggtgg aactaatttg tttgcatcca tgttcttagg tgtagcgatt
    12841 tgtgcagtaa taggattaat caatggtata gtagttgcaa agataaatgt accatcatta
    12901 atagccacta tggctatggt cactattgta agaggattgc tgttgatgct tacaggagga
    12961 tatccaatta ctgaaaatat accaatactt gattacattg gaaatggata tttgtttaat
    13021 ataccaatac cagtagtaat tttctttata gtggtgttag cttcgtttat tgtacttaat
    13081 aaaactaagt ttggtagata tgtttattct gtaggaggga atcaagaagc aagtaaactt
    13141 aatggtataa atgtagattc tcacaaagtg aaagtgttta ttattaatgc tgtacttgca
    13201 ggaatagctg gaatcgtact aacaggaaga cttgggactg caactgcgat tgcaggtgaa
    13261 ggatatgata tggatgcaat tgcatctgta gtaataggag gtacatcagt ggcaggaggt
    13321 tctggttctg tacttaaaac tgttatagga gtattactta tgagtgttat aaacaacagt
    13381 tttaatcttc ttggaataga tgtatatttc cagtacatat ttaaaggatt aataatttta
    13441 gcagcagttg gatttgattc ttatagcaag aaaaaacttg cttcaagata aaaaataagg
    13501 gggatttttt tatgaaaaaa ttaatgaaac atttagcatt gttgctatca cttgttatga
    13561 tatttggttt agttggttgt tcaaatggtg gtgacaaaga aaaaaatgga gaaaagaaaa
    13621 tagcagtatt actaccaggt tcaacaggtt actttgtagc aactaaacaa ggtatagatg
    13681 caaaatctaa agaattaggt gtaagcgttg aatatgcaga tgctcaatgg gatgctagta
    13741 aacaattatc acaagctgaa gattttatgg ctaaaggggt agacatgatt gcattatgtg
    13801 gagttgattc tgctgtaagt gagagaatag ttaaagctgc taatgattca gacgttccta
    13861 tagtagcatt tacaaattct ataggaagta acccaactgg agaatttaaa ggtttagtta
    13921 catatatagg acaaaatgag gaagaaacag gagcattaac tggaaaaatt gctaaaaact
    13981 tattaggaga aactggtggg aaagctgtat taatagaagg agtaccagga actactccac
    14041 aagtattaag aaaaaaaggt cttgaaaaag aattaaaaga tagtaatata gaaatagttt
    14101 ataatcaaac ttcaaattgg gagaaagagc aagctttaaa agtaacagaa gatttaattc
    14161 aaaagaaaac tgattttaat gttataatat gtcaagatga taattctgct acaggtgcag
    14221 gtcaagcttt aaaagatgct ggtcttaagg ataaagttaa agtcataggt ttgggtggaa
    14281 gtaaagatgg attaaaagct ataactgatg ggttaataga tggtacaact tatatgtctg
    14341 ctgtagaaga aggtggatta gtcatagaaa aggcatctaa attccttaaa ggtgaaaaaa
    14401 tagaacctgt tacacaaatt aaacaagttg aagttaacaa agataatatt tcagagttca
    14461 agggtgaatg gtaaattgtc atagataata aataagattt ttagagttac tttagaaact
    14521 atataaagta actctttttt taatttaatt tagtgataaa ttattgaata gtatttctaa
    14581 acaaataaaa aattaatata aacaaagact taattatact aaattataag taaaactaat
    14641 ataaacttat ggaaaaaagg aaaacgtcta aagtattgga attactatag tgtaggtgta
    14701 gtattaaaaa aacataaaaa aacataaaaa aattgttgaa aaaaatatag aaattttgta
    14761 taattaaaga tttgaaaagt gcggtataca aagccaattc ttttgtatat aatatatata
    14821 aattcagaaa aaggaaggga tatgtatggc caggcggtta tttttagaaa ggattggact
    14881 tatattttta ggttcagcaa tattagcatt tggagtttat aatttttatt atttaaacaa
    14941 cataacagaa ggtggagtgt taggtatttt actactgtta aaaaatttat tcaatataca
    15001 accagcaata gcaaatgttg taatagatgg tttactactt ttagtaggat ataaattttt
    15061 cggtaaaaaa ttccttatat attcaatagt agcttctata actttttcag tgttatatga
    15121 cttatttgaa gctataggac ctctagtacc acaatcacaa aatatgcttt tatcaactat
    15181 tttggcaggt gtaactgttg gaactggtgt aggtatagta gtaaaagcag gttgtgcatc
    15241 aggaggagac gatgctttag cattagtaat ttctaagact acatctttga acatagggca
    15301 agtttattta gcaacagatg ttattgtatt gttgttatca ttattttatc tatcagcgtt
    15361 tgatatcttt tattctttga ttgctgttac aattagtggc aaggtaattg attttattta
    15421 ttatcatggt aaaagtttgg atatggatat aagtaatgat atagttccag aatgttaata
    15481 taaattaaat aactttagat tttattaggg gtggcagatt tgccaccttt tttgtgtcta
    15541 aatctttata gaaagtataa tcccatctag gtttttgcaa atctcaaata tagaattatg
    15601 ttggaatgac tgggaatacg attgctagat gtgcatttta aaaacccaat tttatattta
    15661 tgaaatacta atcattaatg gatgtttctt aatcctatct ttatacctaa aatgataaga
    15721 taaatgaagt agcaatacaa aactaaaatt tgtaaaagag attaaattaa atggaggagc
    15781 taaaatgttg gatatagtta tgatagcatt gttattcata ggatttgttt ccatgaagtt
    15841 acttgctgat tggtgtggga aacaaactga aaaaaaataa tgtaatgtat ggagggatta
    15901 cctatgtggt ttctggcagt tgtaattata atgttaataa tatatttggt atatgcgctt
    15961 attaatcctg aaaaatttta aacagtataa ggctaataag taagttgaat tggggggaac
    16021 aatttttatg gtgcagatag taatagtgtt agcgattttt atgattttag taatacctat
    16081 gggcaagtat ttatatcata tagctactaa tcaaaaaaca tttggagata gactatttga
    16141 taaagtggac aattttatat ataaggtatg tagtatagat aagaaaaaag aaatgaactg
    16201 gaaacagtat gcattagctt tattatttac aaatgcagtt atggtattta taggatatat
    16261 catacttaga actcaaagta tgcatatttt taatccaagt ggaattaaaa gtatggaaca
    16321 aggactatca tttaatacaa taataagttt tatgacaaat acaaatcttc aacattattc
    16381 aggtgaatca ggactttcat actttagtca gatgacagtg ataatatata tgatgtttac
    16441 atcagctgca acaggatatg cggctgctat ggcatttgta agaggtctag tcggtaaaaa
    16501 gaaaacattg ggaaattttt atgtagattt aattaggata acaacaagag tacttttacc
    16561 aggagcttta attattgggc ttatattagt tacacaagga gtaccacaaa cttttgctgg
    16621 gacagaaaca gtgactacta tagaaggaaa gcttcaagat atagctagag gtcctgtggc
    16681 agctcttgaa tcaataaaac atttaggaac aaatggtggt ggattctttg gttcaaattc
    16741 atcacaccca tttgaaaatc caacaataat atcaaatata gtagaaatat tatctatgat
    16801 gatattacca ggagcttgtg ttgttgcatt tggtcacatg ataaagaata aaaaacaagg
    16861 ttgggttgtg tttggcgcaa tgtcaatcat atttttaata ggtctagtag tgtgctttaa
    16921 agcagaaagt gcaggaaatc ctattttatc acaattaggg cttaatcaaa gtatgggaag
    16981 tatggaaggt aaggaagtta gatttggtat agcacaatca tcattattca caacagtgac
    17041 tacttccttt acgacaggta cagttaataa tatgcatgat acactgactc ctttaggagg
    17101 attagtacca cttttaaata tgatgctaaa tgtagtattt ggtggtaaag gcgtaggtct
    17161 gatgaatatg ttgatgtacg ctataatagc agtattctta tgtggattaa tggtaggaag
    17221 aacaccagag tttttaacta agaaaatcga aggaaaagaa atgaagctta ttgctttact
    17281 tattatatta catccacttt taatactaat gttctctggt ctttcagtag caataccagc
    17341 agggcttgaa ggaatttcaa atcctggatt ccatggatta tcacaggtat tgtatgagtt
    17401 tgcatcttca gcagccaata atggttcagg atttgaaggt ctaggagata acactatgtt
    17461 ttggaatata acaacaggtg tagttatgtt ctttggaaga tatgtgtcta ttatagtact
    17521 actagcaata tcaagtttgt tagcatctaa aaaagctgta aatgaaagta taggaacact
    17581 tagaacggat aattttacat ttacaatagt tttagtactt gttgttttaa ttgttggtgc
    17641 tttaacattt ttcccagcct tagcgcttgg acctatttcg gagcatctag tgttgtggca
    17701 ctaaaaaatt gggagggagt aaagttttat ggaaactaaa aaaacaaagt ttattacaaa
    17761 agatattttc aaaacttcca ttatagaagc ttttaaaaaa ttaaatccta aatacatgat
    17821 gaaaaatcca gttatgtttg ttgtagaaat tggatttata gtaacattga tacttacaat
    17881 agtacctagt ttgtttggtg atgaaggcaa taacttaaga gcttataatg ggattgtaac
    17941 aataatctta tttataacag tcctttttgc aaattttgct gaagctgtag ctgaaggaag
    18001 aggtaaagct caagcagata cacttaagaa aactagaaaa gatacagtag caagggttat
    18061 agatacgtta ggaaatgaaa aaatgataag tgcaagtgag ctaaaacttg gtgatattgt
    18121 tttagtaaat gctggagaag ttattccaaa tgatggagaa gttatagagg gtatagcttc
    18181 tgtggatgag tcagcaataa ctggagaatc tgcacctgtc atgagagaat caggtggaga
    18241 tttcgcatct gttacaggtg gtactacagt tgtaagtgac tggttaaaga taagaataac
    18301 aacaaaacca ggagaatcgt tcttagataa aatgatagct cttgtagaag gtgcttcaag
    18361 acaaaaaacg ccaaatgaga ttgctttaaa tactttatta gtagggttaa cacttatatt
    18421 tatggttgtt ttaatatctc tttatccaat ggcaaactat gcaggtgtaa agattccaat
    18481 ttctactatg atagctcttt tggtatgttt aataccaact actataggtg gattgttgtc
    18541 agctattggt attgcaggta tggatagagt aactagattt aatgtaattg caatgtcagg
    18601 aaaagcagta gaagcttgtg gagacgttga tactatgatt ttggataaga caggtacgat
    18661 tacttatggg aatagacttg catcagaatt tatagcagtt ggaaatgcag attcaaaaga
    18721 tttaataaat tattctgtta tgtgttcatt aaaagatgat acaccagaag gaaaatctat
    18781 agttgattta ggtatgaaat taggttcaac aggtaagaca aaagaggcag aggaagctga
    18841 gtttgtagaa ttttctgcac aaactagaat gagtggtatt aacttagctg atggtagagc
    18901 tataagaaaa ggtgcttatg atagcataat aaaaagagta aaagaatctg gtggtacagt
    18961 gccagaagat ttagaagaaa atgtaaatcg agtagctaaa ctaggaggaa cacctttagt
    19021 agtgtgtgta gataatgaga tatatggaat tatctactta aaagatacag taaaatcagg
    19081 gcttgtagaa agatttgcta gacttcgaga gataggaata aagacaataa tgtgtacagg
    19141 ggataatccc ttgacagcag ctacaattgc aagagaagct ggagtagatg gatttattgc
    19201 agaatgtaaa ccagaagata aaatagatgc aataaaaaaa gaacaattag agggtaaaat
    19261 agttgcaatg acaggtgatg gaacaaatga tgctcctgca cttgctcagg cagatgtagg
    19321 tcttgcaatg aatagtggta caacatctgc aaaagaagca gcaaatatgg tagatttaga
    19381 ttcagaccca actaagatat tggaagttgt tgaaatagga aaacagcttt taataactcg
    19441 tggggctttg acaacattta gtatagcaaa tgatgttgca aaatattttg cgattatacc
    19501 agctatattt actcttgcaa tacctcaaat ggagatatta aatgtaatga aactttctac
    19561 gtcatttagt gcgatattat cagctttaat atttaatgct ataattatcc catgtttaat
    19621 acctcttgca atgaagggag taaaatatag acctatgaaa tcacaagcta tgttaatgag
    19681 aaatatgctt atatttggtc ttggtggagt tatagtacca tttttaggaa taaaattaat
    19741 tgatttattg attacacctt tagtaatggt tcttaattta ggttaataaa tggaggatat
    19801 aaaaatgaaa acattaaagc cagcattact tgtaagtatt gtattgttag ttgtttgtgg
    19861 acttgtatat ccacttgttt tgacaggtgt aagtcaagtt gcatttaaag ataaagccaa
    19921 tggaagtatg atagaagtaa atggtgtaaa agtaggttca gaacttattg gtcaaagctt
    19981 tacagatgcg agattcttta agggaagagt atcatcagta aactataata cttatacaaa
    20041 agaagattta gtaccagata aagatggaaa tacatcttat ggaggtgtat catcagggtc
    20101 ttttaattat ggagctacaa atccagaact tcatgataga gtacaaaaag atatagaaaa
    20161 gtttttaaag gataatccaa ctgtcaaaag agaggatata ccaacagatt tacttacagc
    20221 atcaggttca ggacttgacc ctaatataag tccagcctct gcaaaaattc agataccagc
    20281 tatagcaaaa gcgtctggaa tatcagaaag taaattacaa aaaattgtag atgataatac
    20341 ttccaaaaaa ctttttggag ttttaggtga agatagagtt aatgtattaa aagttaatgt
    20401 agaggtcgca aaaatattag gtcttatata gtattttgtg gaattttagc aacaaaatat
    20461 tacgcaagat ttaatttaaa ggttaaattt taaagagtga aaatcgataa tgattttcac
    20521 ttttttattt gaatattact aatatttgga ataaagtgat tgtaagtata aaatccaaaa
    20581 aaaggttgca ttatcaaaat gataatacta taatatattt atcgttatca atttgataat
    20641 agatttggac atataggagg aaatagtatg ttatataata acgcattaga gttgatagga
    20701 aacacacctg tagtaaggct gaataattta ggctgtacta atgggtgttc taacatatat
    20761 gtaaaattag aaaaagtaaa tccagcagga agtataaaag atagagctgt ttatgaaatg
    20821 ttagagggct tagagcaaag aggagaatta aaaaagggag atgtactagt tgaagcaact
    20881 agtggaaata ctggtattgc attatctatg ataggaaaat taaaaggata tgaagtagta
    20941 atcgtaatgc ccgaaacaat gagcgttgag agaagagatt taatgaaggc ttatggagca
    21001 aatttggtgc ttacagatgg taaagctgga atggcaggtt ccatagaaaa agcaaatgaa
    21061 cttttaaaag aaaatccaaa ctataaaagc ctaaaacaat ttgaaaataa agataatcca
    21121 aatgcacatt ataaaacaac agcagttgaa attatgaatg atgtcaaaga tttagatata
    21181 ttcgtatgtg gagttggaac aggtggtact ttaataggaa ctgcaagata tttaaaagaa
    21241 caaaatccaa atataagagt aattgcactt gaaccaaaaa aatctccagc tatatcagaa
    21301 aacaagactg gacctcataa aatacaagga ataggtgcta actttgttcc tgaaaattat
    21361 gattctagtg tagttgatga agtaatatta gtagatgatg aagatgcatt tgatacagtt
    21421 aaattacttg cagcaaaaga gggaatttta gtagggatat cttctggagc aaatatattt
    21481 ggtgctatag agatggcaaa aaagtatcca gataaaaaga tagttacagt agctccagat
    21541 ggagttgata agtatatgtc tatgggaata ttttaataat tttatttgag ggagtgaata
    21601 ctttgtttaa gaaaataaat aaagatattg aatatataat gaagaatgat ccagcagcta
    21661 ggtctaagat agaagttttt ttactttatc catcagttca tgcaatgata atgcatagga
    21721 tggctcatgc tctttataag aagaagaagc tttttacagc aagattaata tcccagatat
    21781 ccagatttat gactggcata gaaatacatc ctggtgctaa aatgggggaa ggtatattga
    21841 tagaccatgg aatgggtgtt gtaattggag agacagctga agtagggaat agggtgacaa
    21901 tatatcaagg agctacttta ggagctacag gaaaagatac tggaaagaga catccaactg
    21961 ttggtgatga tgtattaatt ggtgctggaa caaaaatact aggaccttta aatataggtt
    22021 caaattcaaa aattggtgca aattctgttg tcgttaagga tgtacctaat ggtgcaacag
    22081 ttgttggtat accagcaaaa atagtaaaaa taagaaacct agaacctgta aaaaagaata
    22141 aaaaagaagt gtcctatgag tatgatgaat tagataatgt atattatata taggatttat
    22201 ataactataa aataaacttt ataaaaatta ttttaaaagg tatttttttc aaatttgagg
    22261 acataataaa aaagaactga atgttacagt tttggttcat caatctttga taaacaagat
    22321 tttaaatttg tagcgtctag gaggatttta ttatgaaagc aaatgttaat caagatactt
    22381 gtataggttg tggattatgt ccatcaatat gtccagaagt atttgatatg aaggatgatg
    22441 ggaaatcaca tgttatagtt gatgaagtac caagtgatgc tgaagaatca gcagcagaag
    22501 ctagagaaag ctgtccagtt gatgcaatag atgtgcatta ataaaataaa tgcctataaa
    22561 aattgaattt tcaattttta taggcatttg tcttttattc agttagtatt tcaacacctg
    22621 tttctgtaac taaaaccata cattcccatt gagcagataa tttaccatct tttgtataaa
    22681 tagtccaatt attttcttca tcaacaaaaa tttcgtgagt tccttcattt accataggtt
    22741 ctattgtgaa tatcatccca ggaaccaata gcatctcagt ccctttttta gatacataac
    22801 ttacaaaagg gtcttcatga aagcttaatc caactccatg accacctatt tctctaacaa
    22861 cagagtatcc atttttcttt gcataagagt tgatagcatc acctatatct cctaaaaatc
    22921 cccatggttt ggcaacttca agaccttttt ggacacattc ctttgtaact tgaactaatt
    22981 tttttgcatt ttcattaaca ttacctatca taaacattct tgaagcatct gaatagtatc
    23041 cattaaaaat agtagaaaca tctacattta taatatctcc atcttttaag ataatgtctt
    23101 tacttggaat accatgacaa acttcattat ttactgatgt acatacactt ttaggaaatc
    23161 cattatagtc tagtggagca gggatagctc cattttgtag tgtaaagtca tgaaccaact
    23221 tatttatatc ttctgtagac attccaattt cgattttatc tgaaatataa tccaaaattt
    23281 ttgtgtttat tacagcactt ttttttattt cctcaatttg actttcattt tttataatat
    23341 catgagttgg tacaatatga cctaacttag caaatgaatc tattttatta tccatatcca
    23401 tatgacattt tttatatttt ttagtacttc cacaccaaca gctatcattt ctatttaact
    23461 tcataacttt tcatccttct tttattattt atttaaatta tgggttacat aaactatttt
    23521 aaaacataac cattataaat attataacat aaatactaag aaatccttta tagatagtga
    23581 tttattcaaa gtataaatta ttatatggtt attgttgatg aaaagaggat agttaaatgt
    23641 attattggat attagcgcac ttaatagttt agttcaagtt tttcaagaaa atcatatgtt
    23701 agaggacaat tttcctttaa agtatttttt gaatcttcat caagataata atgtacaaat
    23761 gattctgcaa aaaattcttc tataaacttg cttatatatg catgtgcaac ttgcttaggg
    23821 tcataaagct tatatctttc ctgagcaaat acttccataa attcttcaga atttgatttt
    23881 ttatttaaaa catttttatc tatagcatgt gcagtttcat gtaattctaa attttttgat
    23941 gaatgtacat ttgcatagct agggttacta taacctattt tagccactat agaattattt
    24001 ctatatatac caggtacatc tttccaagtc ttgcctgatc ttacccaaca tggaggtaat
    24061 tgatatttta aatcactaaa ttctggttca tcagttagat ttgaatttat taattttatt
    24121 tttatatcct tttctttaag tgtctgtaaa tatttaatat ttatttttgc aagtctgttt
    24181 ttcatatttt caacttcatc tttatcataa ttcaagtcat caggaagtat aagcatttgt
    24241 tcaattatat ctatactact gtcttttata ttttcagatt cttcatcaaa cttatattga
    24301 agagtattat tttcatagat agttatattt gtattatttt ctatagaata agagtgaata
    24361 tcctctaaat ctaaaatatt catttgttgt aaaatatgtt ttgtttcgcc actccatact
    24421 actaaagaaa gtgaattaaa attaattagt ggattttctt ttgcttttat atcattgctt
    24481 atatctacat caaatacata ttcaattgag tcttctatgt taagaccatc tgtattcttt
    24541 ttaatatata aatacgcttg ttttaagtct atataaatct catctaaaga ttcgtcataa
    24601 aattctgata aattattagt aaagagttct tcacttaaaa gttcattttt atcagttata
    24661 ctttcaatta aaatattaat ttcttttatc atatcgtaaa tacttatttt tctatttgct
    24721 ttttcactag atacattgca tggcgcaaga gcaatgcaat aaaaatcttt ttctttttta
    24781 taaaaggctt taagtgattt tgataaaagt gtaaagtcta cacctatctg taagttgacc
    24841 ttaagtgagt cattttgtaa taattcagta ttatttcttt tagctgtatt taaattgttt
    24901 tccataatca ttgccccctt tttattaggg tatcataatt tttttatatg tgtcaatttg
    24961 tttttttgaa aattataatt tttttgaaaa ttttattttt tataatttgt gaattttt
//
LOCUS       DAEHWM010000056        24650 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.057, whole genome shotgun sequence.
ACCESSION   DAEHWM010000056 DAEHWM010000000
VERSION     DAEHWM010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24650)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24650)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24650
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.057"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            59..943
                     /locus_tag="KNP36_002304"
     CDS             59..943
                     /locus_tag="KNP36_002304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0874170.1"
                     /translation="MKKYRLLVTCIIAMGIIIIGTSNPVSNFYKTTNLISSGNITNEK
                     ADKDENSNKNNKDKNEDKSNSKSNKDKSSEDKSSDNKNEIQKNKKLLICIDPGHQGKG
                     DSNLEPVAPGSSSKKARVSSGTEGIATKKPEYVLNLEASLVLKSILESKGYNVIMTRE
                     THDVNISNSERAILANDKKADMVVRIHADSLNNSSKTGASILIPEKDGKYTAPIYEES
                     NKCAEFIKQNMEQSGIQINGIVQRGDLTGFNWSKVPAVLVEMGFMSNYNEDQMMSNPD
                     YQRKMMQCIADGLDAYFK"
     gene            1145..2695
                     /locus_tag="KNP36_002305"
     CDS             1145..2695
                     /locus_tag="KNP36_002305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBF0874171.1"
                     /translation="MLVVENVSHGFGARTILENVSFRLRKGEHIALVGANGEGKSSFL
                     NIITKKLMPDAGNIKWSSRATVGYLDQHTVLSKGKTIREVLREAFKHMFDLEQEMIAM
                     YDKMGEASDDEMSKLLEETAEIQTILENSGFYMIDAKIQEVANGLGLGEIGLDKDVTD
                     LSGGQRTKVLLTKLLLENPTILILDEPTNYLDEEHITWLTKYLQEYENSFVLVSHDIE
                     FINNTCNVIYHMENGELNRYKGNYDEFVRLNDIKKRQEEQAYDKQVEERKRLEDFVAR
                     NKARVATRGMANSRQKQLDKMEILERPKEKIKPTFAFKDARAASKIIFETENLVLGYD
                     EALTKPLNFHLERGKKIALKGMNGIGKSTLLKTLLGIIKPFEGNVKLGDYLEVGYFEQ
                     ESSRENSNTPMDEVWSEFPGLTNFEVRQALAKCGLTNEHITSQMRVLSGGEAAKVRLC
                     KVMLKNINFLVLDEPTNHLDVEAKDELKKAIKEFKGTVLLVCHEPEFYSEIVDDVWNI
                     EDFTTKIV"
     gene            2724..3371
                     /locus_tag="KNP36_002306"
     CDS             2724..3371
                     /locus_tag="KNP36_002306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HBF0874172.1"
                     /translation="MKKFLNVLFSICISIVIIVGVINFTVGFKQLYYFDIDYLNISEL
                     SGLSKDDIKLNYDYLIDYNLNKNVSEFKLPTLKSSPQGKIHFEEVRNIFQNINKLAKL
                     LLVVSLVGIILSVKNKNIKILKTTSITLIIMPLLLTVPILLNFEKSFIIFHKLLFRND
                     YWIFNPDLDPVINILPEEFFFHSGMMILILILLVSIVLFVMYKLCKSLSIKIFQC"
     gene            complement(3513..3773)
                     /locus_tag="KNP36_002307"
     CDS             complement(3513..3773)
                     /locus_tag="KNP36_002307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich small domain-containing protein"
                     /protein_id="HBF0874173.1"
                     /translation="MGENYKFFNHKDCEFFPCHKTNKPEEFNCLFCYCPLYALGENCG
                     GNFRYTDKGIKDCSSCILPHKKDNYNYIMSKFQDLVKITSKK"
     gene            3990..5273
                     /gene="hflX"
                     /locus_tag="KNP36_002308"
     CDS             3990..5273
                     /gene="hflX"
                     /locus_tag="KNP36_002308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HBF0874174.1"
                     /translation="MKEIQEKALLVGLNLTTIVKKNDDIDTNESMEELKELTKAAGAE
                     VVGSLIQNKHSVDAAYYIGKGKVEEIRAYSDSLDATLVIFNDELSGAQIRNIENVVGR
                     KVIDRTTLILDIFAQRALSKEGKLQVELAQLKYRLPRLYGMGGEMSRTGAGIGTRGPG
                     EQKLEIDKRHILNKAADIRRELKEVKKNRETQRVKRLKSNIPIVALVGYTNAGKSTLL
                     NELIKTHKDYEQEKEVFVKDMLFATLDVTLRKALLPNKKEFLVVDTVGFVSKLPHDLV
                     EAFKATLEEVQYANLILHVIDATNTSYELQKSTTEGVLKELGVNDKKHILVYNKVDKL
                     ELDIYPKSQEDIVYISAKQGINMDKLLNMIEIALMENTYSVSLMLPYERGDIFSRIKD
                     KYNVENFEYGESGITLDADLDEEDFNIYREYILEK"
     gene            5281..5958
                     /locus_tag="KNP36_002309"
     CDS             5281..5958
                     /locus_tag="KNP36_002309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="HBF0874175.1"
                     /translation="MDINWENIDNLEDYFITYLLYKESKTVSQISKIRNISSTEASEQ
                     LIQAKLKIKEMQKDDFEASKDILDKFLELDKIKRLDFMDSLDDEKMVYFKRKVFKRIL
                     VEKNAEDLIVLIWATGELKDDRFLKLLHQLTNHRHSDIRRITYSAIRKIESPSSREVL
                     QKGLYDKNAQTRQYCAKALSKLGDENSLKILQQLKDKNKNFEKEYVLRAYDEAIKSLE
                     NAKNLKK"
     gene            6044..6487
                     /locus_tag="KNP36_002310"
     CDS             6044..6487
                     /locus_tag="KNP36_002310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HBF0874176.1"
                     /translation="MIVRRCAGGVVFYANKVLIVKNDRGEWTLPKGKILGGGLPYESA
                     VQRVKVETGIDAKMIDVAGDTMYEFFSRSRQQEVCNAIMWYVMEACNTDCVLAPEFQE
                     GGFYKVKDALEMLSHHKEQALVEVSYKKFKELKKLVSEGDDVPAN"
     gene            6792..7436
                     /locus_tag="KNP36_002311"
     CDS             6792..7436
                     /locus_tag="KNP36_002311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888588.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HBF0874177.1"
                     /translation="MSNYRTLHEFGTDEITIEKSVFIGYAKPIKSEEEALEFINEIKK
                     KHKDATHNVWAYTVGKNMNIQRYSDDGEPQGTAGIPTLEVIKKEDLRDVAVVVTRYFG
                     GTKLGAGGLVRAYTKGAKLGLEAGKIIYKVMYQEVKVKIDYTQLGKVQNELMNLGYFI
                     KDTVYEDNVEIVVYSRLEDVEKLSEKMIDITSGTGKIVLGEEFYLSEQNGEILI"
     gene            complement(7522..7899)
                     /locus_tag="KNP36_002312"
     CDS             complement(7522..7899)
                     /locus_tag="KNP36_002312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HBF0874178.1"
                     /translation="MLFALIGFFAGIIGGMGMGGGTILIPALVLLAGIDTKIAQSVNL
                     LSSIPMTLIALAIHIKNKNVIFKLVIPIAVFGVLGAVFGSLLANYLSSDILKKIFGIF
                     LLLVGLFEVKKGFCAKSDKKPLN"
     gene            complement(7899..8285)
                     /locus_tag="KNP36_002313"
     CDS             complement(7899..8285)
                     /locus_tag="KNP36_002313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HBF0874179.1"
                     /translation="MKKTDDLKKKYFDFNLKNTIIGVFTGFINGVFGSGGGTLLVPIL
                     NDIVKVEEHKSHATALSIIIFLTTASSVLYVSKGTYDVNLTIKVAVGSILGGIIGAKL
                     LNKVTGKFLRISFGIIMIIAALRMVF"
     gene            8464..9219
                     /gene="nadE"
                     /locus_tag="KNP36_002314"
     CDS             8464..9219
                     /gene="nadE"
                     /locus_tag="KNP36_002314"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+) synthase"
                     /protein_id="HBF0874180.1"
                     /translation="MSNIKIQIDKTVEWLINKVNEANAKGLIVGVSGGIDSAVVANLI
                     KKAFPENSMGVIMSIKSNPQDREDALKVIEGCDIEYLDLDLIEPQSAILDMVVGNLKD
                     KHLYREEYLKMTDANLRARVRMSTIYTIANNLGYLVVGTDNAAEIHTGYFTKFGDGGV
                     DILPIANLTKGEVYEWAKELGVHEDLINKAPSAGLWEGQTDEDEMGTTYNMIDAVLEG
                     RLDEVPKRDQEIIERLHRLSEHKRKTPAQPPKF"
     gene            9302..10021
                     /locus_tag="KNP36_002315"
     CDS             9302..10021
                     /locus_tag="KNP36_002315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBF0874181.1"
                     /translation="MGRIGNIINRKGKQDAQRAKIFTKHARAIAVAAKEGGADPEYNA
                     ALKTAIEKAKADNMPNDNIDRAIAKGAGAGAGEDYETIVYEGYGPGGVAVIVETLTDN
                     KNRTAGNVRYYFDKNGGNLGTSGCVSFMFDKKGQILVGLGDGVSEEELMDVALEAGAE
                     DFITEEDGYEIITTPEDFSSVRDELKAKGYEFISADVKMIPQTTTVLTEESHLKMMNK
                     LVDMLEEDDDVQDIYHNWEVE"
     gene            complement(10188..11192)
                     /locus_tag="KNP36_002316"
     CDS             complement(10188..11192)
                     /locus_tag="KNP36_002316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HBF0874182.1"
                     /translation="MATIKDIAKDCGLSSATVSYVLSGKGNERRIPLHTQELILNSAD
                     KLGYKRSTPIKHNNIKIAFYWQDEGFELASTNILQAINHIISLEHLNINIIIRPYKVG
                     HLCDDEYFFANNYYDGIVLTGINADDIEYLVKNKPKIPVVVVNREIPGFSSVSIDNEE
                     TGRIAALHAIQNGKNDIAVVFNPTSFTCMTLRGKSFLKTCKEHGIHLSDSIYYCSNKI
                     DSGYDIAQKMLAKNSLKKVIFCNHDVVALGMMNAFHESGIVIGEDIQIFAASNGPSRL
                     MARSIPPLTVIDLKMEETAERSLRMIIDTVTGRINGIQQQVIYPSIIYRQSSPAQNLL
                     "
     gene            11458..12354
                     /locus_tag="KNP36_002317"
     CDS             11458..12354
                     /locus_tag="KNP36_002317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="HBF0874183.1"
                     /translation="MSKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEI
                     SSFVSPKAIPQMKDAKEVATYCVEKYPDVKLYALVPNLYGAKVAWECGIRDISYVISL
                     SETHNKKNINRTHEESIDELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAK
                     RLWENGIREINLADTIGIADPKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVA
                     IESGITTVQSTLGGLGGCPFAPGASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQ
                     KSFVNGVYSGHHVNIKSDSCNC"
     gene            12475..13737
                     /locus_tag="KNP36_002318"
     CDS             12475..13737
                     /locus_tag="KNP36_002318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874184.1"
                     /translation="MDIIALLLFLGVIIIAFVRKNNAGILALAIGVIAVRIFGMDDKE
                     LYGAISNSMFTTLVGITLLFAIVNSTGALKLVAEKIVAASGKRVWLIPIAVFIAGFVV
                     AGVGPGAIPALAIIPAMAVPVAITVGYNPVMLALIGECGLMAGRMTPITPEGQIITTV
                     AEGVGIENVMPTILACQTLSTIVFSIVLFIIFKGYKLKKPINVIDSKQIEKFNIKQII
                     SLISIVVMIAFIIIFDMNVGLAAFAVSAVLIFFNIADEGECIKSIPWSTIVMVLGVGA
                     MMTIVDAAGGIDLMSNALSSLMNSKTATPIMSISAGLMSMVSSALAVVYPTMMPMCVD
                     IAKAVGGVDPLALIAAVGVGGSLAGVSPLSTGGALILAAMGSSKKDFNKEEQNKVFVQ
                     LFIMSAVGLLVIAVVSILSFNAITHLMN"
     gene            13813..15006
                     /locus_tag="KNP36_002319"
     CDS             13813..15006
                     /locus_tag="KNP36_002319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase"
                     /protein_id="HBF0874185.1"
                     /translation="MKKGALSNIKVLDLTRVLAGPYCTMMLADFGADVIKIEMPRKGD
                     DTRGFGPFVNGESLYYANINRNKKGITLNLKSEEGKNIFLEMVKHADVVVENYRPGVM
                     EKLGLGYDELAKVNNQIIYGAVSGFGCYGPYSERPGYDIIAQAMGGLMSITGQEGGEP
                     TRVGNAMGDVLGGMNLTIGILTALNARKIIGKGQRVDVSLVDSVVSSLETGIQRYFDS
                     GQPELMGNRYASAYPYDSFKASDGSFVIGCGNDKLFEKLCKKVLFREDLLIDERFKTN
                     LNRCEHYKALKPEIEKWSVKHTIKEAVDLISEAGVPAAPIYNLDCVTTDEHIAKAREM
                     IVDISHPIIGNMKVNGNPVKLMTTKAKIDMPAPSLGESNEEIYNGWLGFDSDKIKDLK
                     ENGVI"
     gene            15635..16429
                     /locus_tag="KNP36_002320"
     CDS             15635..16429
                     /locus_tag="KNP36_002320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="HBF0874186.1"
                     /translation="MESVMENLNNLKVEVKDKVCVITINRPKALNALNSDTLRELSQV
                     IDVVSENEAILGVIITGEGKVFVAGADIRQMQNYKSEEGRKYAGYAQGIFDKIEALEK
                     TVIAAVNGYALGGGCELAMSCDIRIASEKAIFGQPEVNLGVIPCFGGTQRLSRLVGTG
                     IAKELIFTGRQVNAEEAKSIGLINKVVPSDLLLEESMKMMNQIVEKAPIAIRYAKVVI
                     NKGIDMDLKNALELEKDVAGLTFATRDKQEGMNAFIEKRKPVFENK"
     gene            16524..17864
                     /locus_tag="KNP36_002321"
     CDS             16524..17864
                     /locus_tag="KNP36_002321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBF0874187.1"
                     /translation="MNTGVIISLVGIIIALSLLVVMVMKGINIFIIAIVCSSLVAITG
                     SLNVYDALKVDYMTGFVGFLQANFFIFLTGTLMGKIMEITGGAKSIAKMIVRWIGKDK
                     ALLSIPIACGILAYGGVSVFVVSFAVFPIALEIFKEADLPRRFIPAALTFGCSTFAMV
                     APGAPQIQNIVPASTLGTDIMAGAVNGFISCAVMFIVGSTILYKMVSKEKANGGHFIA
                     HESDIFDEAEATNSKRENGPNGVIALIPLIVSILIINVKVNGKAIVPIEVGVFIGALL
                     VYLLLNKYQDNTKIVGHVGDACKTTVVAICNTCAVVAFGSVVKSAVGFDFIVNAMTNI
                     PGPPIAGAAVGTTVIAGICGSASGGLGIAAPLLGPVFLAKGVSAAALTRTMAISSAAL
                     DSLPHNGYIVTVTNGLCKETHKDAYMPIFWVTVLTPFIGTIVAVLLFTMFPGLP"
     gene            18001..19233
                     /locus_tag="KNP36_002322"
     CDS             18001..19233
                     /locus_tag="KNP36_002322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA transferase"
                     /protein_id="HBF0874188.1"
                     /translation="MLNKPLEGVKVIDLTYFVAGPGTSKILADWGADVIKVEPSFGDP
                     GRKTGATMTMPIDDYNNPFYSTYNSNKRGLSINLKSETGIEIMDKLLSEANVFVSSYR
                     TGALKRLGLDYESLSKKHPHLIWGQINGFGDFGPAKDNAGFDTVAFWARSGAMLDIAE
                     KDTSPINPPIAFGDATTSCSLSGGICAALYQQAKTGKGQKVMASLFGQAIWNASSLLA
                     STQFSDEYPKTRKNAISPVINSYRCKDGKWIFLSILEHERYFEALCRLFGREDLIKEE
                     KFASSVESKKNATELINILDGEFAKFTQNEMVEKLTAADIAHEKIQHVNDVVTDEQAI
                     ANNYIYEHTSKDGNKTMLASTPVKFGNIEVNMTCDAPLIGEHSDEILRELGYSDSDIE
                     TLIESGIVTMNKEACEIC"
     gene            19273..20415
                     /locus_tag="KNP36_002323"
     CDS             19273..20415
                     /locus_tag="KNP36_002323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="HBF0874189.1"
                     /translation="MDFRLTEAQLMLQRVAKEFAENEIAPIAAETDKTGIFPRELFSK
                     MAKIGFNGIGTPVEYSGSGGADIEKVIVVTEIAKKCAASAAILSIHTIYAQAILKFGT
                     EEQKKKYLPMMAEGGCVGAFALTEPNAGSDAARAATTAIIDEETDEYVLNGTKCFISG
                     GGQAESLIIFALTDPSKGIKGMSAIIVDKGTPGFSIGKIEEKMGIHGSETAELIFDNC
                     RVPKSNLLGKEGKGFNIAMTCLDGARIGVGAQAVGIAEGALEESIKYSKERVQFGKPI
                     SALQGIQWYIADMATMVESAKLLVYYAADLKARGEKHTKEAAMAKYNASRTAREVTNL
                     ALQIHGGYGYMKDYPLERMYRDAKITEIYEGTSEIHKVVISRAVLG"
     gene            20426..21220
                     /locus_tag="KNP36_002324"
     CDS             20426..21220
                     /locus_tag="KNP36_002324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBF0874190.1"
                     /translation="MNIVVCLKQVPDTNEVKINKETGTLIRDGVPSIINPDDRNALEE
                     ALKMKDELGAVIKVISMGPPQAKSALKEALAMGADEAYLISDRAFGGSDTWATSTIIA
                     AAIEKVGKYDVIFCGRQAIDGDTAQVGPEVAEFLGIPQVTYAKEVKVQDDKLLVTRYT
                     ETGDYLIEAKMPVLLTAIKELNNPRYPSVKGILEAYNNGDAKITVLTLADLDVDTTQI
                     GLKGSPTNVYKSFVPVKDKHNEIIEGINKKEKAEKLIEILFDLKLV"
     gene            21231..22253
                     /locus_tag="KNP36_002325"
     CDS             21231..22253
                     /locus_tag="KNP36_002325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBF0874191.1"
                     /translation="MMRAKVNQGINLNDYNGVWVIGEQREGKINPVTIELIGEGRKLA
                     DQLGKELAVVIAGYEVEKEVKELLHYSVDKVYYINDPLLKDFTTDGYAISIANLIERK
                     KPEVVLVGATSIGRDIAPRIAGKVGTGLTADCTKLEIDSTDNKLLQTRPAFGGNLMAT
                     IVCPKNRPQMSTVRPGVMAKAVRNESETGILEVVTPELTEKMIRTRLVEILPQEKKSV
                     NLTDARIIVSGGRGLKRAEGFELIKELADKLGAEIGASRAAVDSGWIEHSHQVGQTGT
                     TVRPELYIACGISGAIQHLAGMSDSKYIVAINKDAKAPIFSICDYGIVGDLYEIIPEM
                     IESLNR"
     gene            22352..23728
                     /locus_tag="KNP36_002326"
     CDS             22352..23728
                     /locus_tag="KNP36_002326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="HBF0874192.1"
                     /translation="MKEQWYKDIFARVLSMTDDGFIVVNTSGVIIDINDKYCDFLGKE
                     RKDIIGQNIQSIIPNTKMLDVMKNKYCEEGAIHHYSGGNTKEKSVIVSRSYVENDNGE
                     VVAGVAQVKFRLQSFDVAKKLMSEYMELQYYKEQFKDNCGFDKLIGENRDFIELKKTG
                     VKASKTNFPVLLTGETGTGKEVFARAIHNNSSRSDKPMVSINCAAIPEELLESELFGY
                     DEGAFTGAKKGGKKGKFLVANNGTIFLDEIGDMPLTMQAKLLRVLQESEIEPVGGLKT
                     IKIDVRVISATRKNLSKMVEEGLFREDLYYRLNVINIHMMELKDRQDDILLLANYILN
                     KLNVEYKELKVLSDKVKNCFINYTWPGNIRELQNVIKSAYAVSDDMVIMMCDLPSKMD
                     NISRVAQCNVDSNCSIHEMVENYEKSLIIDVLRKYNWKCSKAAEVMGIHKSLLYKKIK
                     KYEIELNN"
     gene            complement(24060..24404)
                     /locus_tag="KNP36_002327"
     CDS             complement(24060..24404)
                     /locus_tag="KNP36_002327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874193.1"
                     /translation="MDQIKRLHELQQKSYLTKEEFEELKNNTYIERFELRDECDNSYI
                     YTFYTNDKCNDIKFIKSQFIVTLIKIGFLCECGGVFRQKKIVDEYDYGYNAIYKCDSC
                     GKELDKEVENYD"
BASE COUNT         9363 a         2867 c         4700 g         7720 t
ORIGIN      
        1 acatattcat ataaataaaa ataaacaata actgtctagc ataagaaagg agcaaaaaat
       61 gaaaaaatat agattgttag ttacttgtat aattgccatg ggaatcataa ttataggaac
      121 atcaaatcca gttagcaatt tttacaagac tacaaatttg attagttcag gaaatatcac
      181 aaatgaaaaa gcagataaag atgaaaattc aaacaaaaat aataaagata aaaatgaaga
      241 caaatctaat tctaaaagta ataaagataa gtcatcagag gacaaatcgt cagataataa
      301 aaatgaaatt caaaaaaata aaaaactttt aatttgtata gacccagggc atcaaggaaa
      361 aggagatagc aatttagaac cagtagctcc aggttcttcc tctaaaaaag cgagagtatc
      421 ttcaggaaca gagggtattg ctacaaaaaa gccagaatat gttttaaact tagaagcatc
      481 tcttgtttta aagagtatat tagaatctaa aggttataat gtaataatga ctagagagac
      541 acatgatgta aatataagta attcagaaag agcaatactt gctaatgaca aaaaagcaga
      601 tatggttgta agaatacatg cagatagttt aaataattct tcaaaaactg gagcatctat
      661 attgattcct gaaaaagatg gaaaatatac agctcctata tatgaagaaa gtaataaatg
      721 tgctgaattt atcaaacaga atatggaaca atcaggtata caaatcaatg gaatcgttca
      781 aagaggtgat ttgactggat tcaactggtc aaaagtacca gctgtattag tagaaatggg
      841 atttatgagt aactataatg aagaccaaat gatgtcaaat ccagactacc aaagaaaaat
      901 gatgcagtgt atagctgatg gattggatgc gtattttaaa taagatatga atagagaaaa
      961 agttaggttg gtattatttg cctaattttt atctctattt tttattgtac ataacacaaa
     1021 gaagaagttt attttaggtt aaattgtcgt aaatataact aaaaatattg ggaatacttg
     1081 atttaagttt aaaaagaata tattatagta tagaatgtgt aaaatttttt tgagaggtgt
     1141 tgaaatgcta gtagtagaaa atgtgagtca tggatttggt gcgagaacaa tattagaaaa
     1201 tgtatccttt agacttagaa aaggtgaaca tattgcacta gttggtgcta atggagaagg
     1261 aaaatcgagt tttttaaata taataacaaa gaagcttatg ccagatgctg gaaatataaa
     1321 atggtcttca agagctacag taggttactt agaccaacat acggtattaa gcaagggaaa
     1381 aactataaga gaagtgctta gagaggcttt taagcatatg tttgacttag agcaagaaat
     1441 gattgctatg tatgacaaaa tgggagaagc tagtgatgat gaaatgagta agcttcttga
     1501 agaaacagca gagatacaaa ctatacttga aaatagtggt ttttatatga tagatgcaaa
     1561 gatacaagaa gttgcaaatg gtcttggtct tggagaaatt ggtcttgata aagatgtaac
     1621 tgacttaagt ggagggcaaa gaacaaaagt acttcttact aaacttctac ttgaaaatcc
     1681 aactattctt atattggatg agcctacaaa ctatttagac gaagagcata taacatggct
     1741 tactaagtac cttcaagagt atgagaatag ttttgtctta gtttctcatg atattgaatt
     1801 tataaataat acatgtaatg taatatatca tatggaaaat ggagagttaa atagatataa
     1861 aggaaattat gatgaatttg taagacttaa tgatataaag aaacgtcaag aagaacaagc
     1921 ttatgataaa caagttgaag aaagaaaaag actagaggat tttgtagcta gaaataaagc
     1981 tagagtagca actagaggaa tggctaacag taggcaaaag caacttgata agatggaaat
     2041 attagaaaga ccaaaagaaa aaataaaacc tacttttgct tttaaagatg ctagagcagc
     2101 tagtaaaata atttttgaaa cagaaaattt agttttaggg tatgatgaag cattgacaaa
     2161 accacttaat ttccatttag aaagaggaaa aaagattgcc ttaaaaggaa tgaatggtat
     2221 tggaaaatct accctattaa aaactttact tggaataata aaaccatttg aaggaaatgt
     2281 taaattaggt gactatttgg aagttggata ttttgaacaa gagagttcaa gagaaaatag
     2341 taatacacct atggatgaag tttggagtga atttccaggg cttacaaact ttgaagttag
     2401 acaggctctt gcaaaatgtg gacttacaaa tgaacatata acgagtcaaa tgagagtatt
     2461 aagtggtgga gaagctgcta aggttagact ttgcaaagta atgttaaaaa atataaattt
     2521 cttagtatta gatgagccta caaatcattt agatgttgag gcaaaagatg aattgaagaa
     2581 ggctatcaaa gagtttaagg gaacagttct tttagtatgt catgagccag aattttattc
     2641 agaaattgtt gatgatgtat ggaatataga agattttaca actaaaatcg tgtagtgatt
     2701 taacttattg ctggggggat ttcatgaaaa agtttctaaa tgtacttttt tcaatttgta
     2761 ttagtattgt tataatagta ggtgttatta attttactgt tggatttaaa caactttatt
     2821 attttgacat tgattactta aatatatcag agttatctgg tttatctaaa gatgatataa
     2881 aattgaacta cgattatcta attgattata acttaaataa gaatgtgtct gagttcaaat
     2941 taccaacatt aaaatcttct ccacaaggga agatacattt tgaagaagtc aggaatatat
     3001 ttcaaaatat aaataaatta gctaaattat tattggtagt ttctttagta ggaattatat
     3061 tgagtgtaaa aaataaaaat ataaaaatct taaaaactac atcaataaca cttataatta
     3121 tgccattatt attaacagtt ccaattttat taaattttga aaagtcattt attatttttc
     3181 ataaattatt atttagaaat gattattgga tatttaatcc cgatttagac ccagttataa
     3241 atatattgcc agaggaattt ttttttcact ctggaatgat gattttaata ttaattttgt
     3301 tagtaagtat agtactgttt gtaatgtata aattatgtaa atctttatca ataaaaatat
     3361 ttcaatgtta aatagaggga tatttttatt tccaaaataa gataataaaa aaggattaga
     3421 ttaaaagtta tacaataaaa atagctgtgc aataatattt agactatgaa agtagttgaa
     3481 aaatatttat gcacagctat ttataataga atttactttt tactagtgat tttaactaaa
     3541 tcttgaaatt tactcataat gtaattgtaa ttatcttttt tatgaggtaa tatacaacta
     3601 ctgcaatctt tgataccttt atctgtatac ctaaagtttc caccacagtt ttctcctaaa
     3661 gcatacaaag gacaatagca aaatagacag ttaaactctt ctggtttatt agttttatga
     3721 caagggaaaa attcgcaatc tttgtgatta aaaaacttat aattttcgcc catattttcc
     3781 tcctaattaa ataaaattta aattttttat actatataag attttggtga taatataatt
     3841 atactaaata attttatgaa tagtcgataa tatagtatta ttaatcatag tattaatggt
     3901 ataattagtc aacagaaaaa taatgtaaaa ataatgtaag tgtattttgt aattagaata
     3961 tgttttataa caaaaaatga ggtgattaag tgaaagaaat tcaagaaaaa gcacttcttg
     4021 taggtctgaa tttgactaca atagtgaaaa aaaatgatga tatagacact aatgaatcta
     4081 tggaagaatt aaaagaacta acaaaagctg ctggggcaga agttgtaggt agcttaattc
     4141 aaaataaaca ctctgtagat gcagcttatt atataggaaa aggtaaagta gaagaaataa
     4201 gagcctatag tgactcttta gatgctactt tagtaatttt taatgatgaa ttatctggtg
     4261 ctcaaatcag aaatatagag aatgttgttg gaagaaaagt aatagataga actactttaa
     4321 ttttagatat atttgctcaa agggcactta gcaaagaagg taaattacaa gttgaattag
     4381 cacaattaaa atatagattg ccacgacttt atggaatggg tggtgagatg agtagaacag
     4441 gtgcagggat tggtactaga ggtcctggag aacaaaaact agaaatagat aagagacata
     4501 tacttaataa agcagcagat ataagacgtg aacttaaaga agtaaaaaag aatagagaga
     4561 cacagagagt taagcgttta aagtcaaata taccgattgt agcacttgtt gggtatacaa
     4621 atgcaggaaa atctaccctg ttgaacgaat taataaagac acacaaggat tatgaacaag
     4681 aaaaagaagt ttttgtaaaa gatatgcttt ttgcaacttt agatgtaact ttgagaaagg
     4741 ctcttttgcc gaataaaaaa gaatttttag tagtagatac tgttggattt gtaagtaaac
     4801 ttccccatga tttagtagaa gcgtttaagg caacattgga agaagtacag tatgcaaatt
     4861 taatcttaca tgtaattgat gcaacaaata ctagttatga attgcaaaaa agtacgactg
     4921 aaggtgtatt aaaagaactt ggtgtaaatg ataaaaaaca tatacttgta tataataaag
     4981 tggacaagct agaattggat atatacccta aaagtcaaga agatattgtg tatatttctg
     5041 caaaacaagg cataaatatg gataagttat taaatatgat agaaattgct ttaatggaaa
     5101 atacttattc agtaagtttg atgttacctt atgagagagg tgatatattt agtagaataa
     5161 aagataaata taatgtggag aattttgagt atggggaaag tggtataacg ctagatgcag
     5221 atttagatga agaagatttt aatatctata gagagtacat actagaaaaa taggttgaat
     5281 atggatataa actgggaaaa tatagataat cttgaagatt attttataac ctatcttctt
     5341 tataaagaat ctaaaacagt atctcaaatt agtaaaatta gaaatatttc aagtactgaa
     5401 gcaagtgagc aacttataca agcaaagtta aaaataaagg aaatgcaaaa agatgatttt
     5461 gaggcatcta aggatatttt ggataaattt ctagaactag ataaaattaa gagacttgat
     5521 tttatggata gcttagatga cgaaaaaatg gtatacttta agagaaaggt tttcaaaaga
     5581 atccttgtag aaaaaaatgc tgaagattta attgttttaa tttgggcgac aggtgagcta
     5641 aaagatgata ggtttttgaa attgcttcat cagctcacaa accacagaca ctcagatatt
     5701 agaagaataa cttattcagc aatcagaaag attgaatcac caagtagtag agaagtactg
     5761 caaaaaggtc tctacgacaa aaatgcacag actaggcagt actgtgcaaa agctctttca
     5821 aaattgggag atgaaaacag tttaaagatt ttacagcagt tgaaagacaa gaataagaat
     5881 tttgaaaaag aatatgtgct tagagcttat gacgaagcca ttaagtcatt ggaaaatgca
     5941 aaaaatttga aaaagtaatt ttttattaaa gcaatttgtt tacttaatga tgtatttcta
     6001 aagtttaaca aggtaataaa taaattaatg ggaggggttt caaatgatag taagacgttg
     6061 tgcaggtgga gtagtgtttt atgctaataa agtacttatt gtaaaaaatg ataggggtga
     6121 atggacactt ccaaaaggaa agatactagg agggggactt ccatatgaga gtgctgttca
     6181 aagagttaaa gtagaaactg gcatagatgc taaaatgata gatgtggctg gcgatactat
     6241 gtatgaattt ttctcaagaa gtagacaaca agaagtttgt aatgcaataa tgtggtatgt
     6301 tatggaagct tgtaacactg attgtgtact tgctcctgaa tttcaagaag gtggatttta
     6361 taaagtaaag gatgctttag aaatgttatc acatcataaa gagcaagctt tagtagaagt
     6421 atcttataaa aagtttaagg aattaaagaa attagtttca gagggcgatg atgttccagc
     6481 aaattaattg tgaatttaga ggattctgag gaagggatag ccccttcctt ttttaattga
     6541 agcagtttta agcgtaaatt atatagtctc tttaaactat gatttatcaa tttagagatt
     6601 tagtagttta tatttaaaat cagtaagata tatttaaaat aaaaattaaa aagtatacaa
     6661 ttttattata taattgtctt atgatgttga ttaaagaagt attaaaagtc catttatttt
     6721 taaatagaat gattttataa atatatattt gatgtgtata ttagaaaatg attaaaatag
     6781 gaggaaatac aatgagcaat tacaggacat tacatgaatt tggaacggat gaaataacga
     6841 ttgaaaagtc tgtttttatt ggatatgcta agcctataaa gagtgaagaa gaagcattag
     6901 agtttataaa tgaaataaag aaaaagcata aagatgcaac tcataatgtg tgggcttata
     6961 ctgtaggtaa aaatatgaat atacaaagat atagtgatga tggagaacca caaggaacag
     7021 ctgggatacc tacattagag gttataaaaa aagaagattt gagagatgta gcggttgttg
     7081 ttactaggta ttttggagga acaaaattag gtgcaggtgg tctagttaga gcttatacaa
     7141 aaggtgctaa actgggactt gaagcaggta agataattta taaggtaatg tatcaagaag
     7201 ttaaggttaa gatagattat actcaacttg gaaaagtgca aaatgagtta atgaatttgg
     7261 ggtattttat aaaagatact gtatatgagg ataatgttga aatagtagta tattcaagat
     7321 tagaagatgt agagaaatta tcagaaaaaa tgattgatat aacaagtgga acaggaaaaa
     7381 tagttttagg agaggaattt tatttgtctg aacaaaatgg agaaatttta atataatcta
     7441 aaaggttatt agaatagtta atacctcaaa tagccaatta gtatttttaa gtgaaaagcc
     7501 attaaattga tttaatctaa atcaatttaa tggcttttta tcggattttg cacagaatcc
     7561 tttttttact tcaaataaac cgactaaaag taaaaatatc ccaaatattt tttttaatat
     7621 atctgaagac agataattag ctaatagtga accaaataca gctcctaaaa ccccaaacac
     7681 agctataggt ataaccaatt taaaaattac atttttattt tttatatgta tagcaagtgc
     7741 tataagtgtc atagggatag atgaaagtaa atttacgctt tgtgctattt tagtgtctat
     7801 gccagcaagt aaaacgagtg caggtataag gattgttcct ccacccattc ccattcctcc
     7861 aataattcct gcaaaaaatc caattagagc aaataacatt aaaacaccat ccttaatgct
     7921 gcaattatca taattattcc aaaagaaatt ctaagaaact ttccagtaac cttatttagt
     7981 aatttagctc ctataatacc accaagaata cttccaactg caactttaat tgttaagtta
     8041 acatcataag tacctttaga tacatataaa acagaacttg ctgtcgttaa gaatattatt
     8101 atagaaagag cagttgcatg agatttatgt tcttctacct taacgatgtc atttaatatt
     8161 ggaactaaaa gagtacctcc tccagaacca aaaactccat ttataaatcc tgtaaaaact
     8221 ccaattatcg tattttttaa attaaaatca aagtattttt tctttaaatc atcagttttt
     8281 ttcataaaaa tcaccttctg aaatagtttt accaaaatag gcaaattata tttatataaa
     8341 ataagattaa atataatctt tcatgtttgt ttaattttgc ataaaaaaaa acatattaaa
     8401 acaacatatt aatatatggt ataatatatt aaaacaaagt agcaaatttg agaggagata
     8461 acaatgtcaa atataaaaat acaaatagac aaaactgtag aatggcttat aaataaggtt
     8521 aatgaggcaa atgcaaaagg attaattgtt ggtgtatctg gaggaattga ttcggcagta
     8581 gttgctaatt taattaaaaa ggcatttcca gaaaactcta tgggagttat aatgagcata
     8641 aaaagtaatc ctcaagatag agaagatgca cttaaggtta tagagggatg tgatatagaa
     8701 taccttgatt tagaccttat agaaccacaa agtgctatat tagacatggt agtaggaaat
     8761 ttaaaagata aacatttata tagagaagaa tatttaaaga tgacagatgc aaacttaaga
     8821 gcaagagtaa gaatgagtac aatttataca attgctaaca atctaggata tctggttgtt
     8881 ggtacagaca atgctgcaga aatacacaca ggatatttta ctaaatttgg tgatggtgga
     8941 gttgatattt tacctattgc aaatttaact aaaggagagg tgtatgaatg ggcaaaagag
     9001 cttggtgttc atgaagattt aataaacaaa gctccttcag caggtctttg ggaaggtcaa
     9061 acagatgaag atgaaatggg aactacttac aatatgatag atgctgtatt agaaggtaga
     9121 ttggatgaag ttcctaaaag agaccaagag ataattgaaa gacttcatag attaagtgaa
     9181 cacaagagaa aaacgcctgc acaacctcct aagttctaat ttactattta taagatttgt
     9241 gataaaattt acaagtgatg aaaattagaa taattaattg tacgtattaa ggagtggaaa
     9301 tatgggacgt ataggtaata taattaatag aaaaggtaaa caagatgctc aaagagcaaa
     9361 gatatttact aaacatgcta gagcaatagc agttgcagct aaggaaggtg gagcagaccc
     9421 agagtacaat gcagcgttaa aaacagctat agaaaaagct aaggcagata atatgccaaa
     9481 tgataatata gatagagcta tcgctaaagg tgctggagca ggtgctggag aagactatga
     9541 aactatagtt tatgaaggat atggacctgg tggagttgct gttatagtag aaactttaac
     9601 tgacaacaaa aacagaactg ctggtaacgt aagatactat tttgacaaaa acggaggaaa
     9661 cttaggaact agtggatgtg tgtctttcat gtttgataaa aaaggacaaa tattagttgg
     9721 tttaggagat ggagtttcag aagaagaatt gatggatgtt gcattagaag caggagctga
     9781 agatttcata acagaagaag atggttatga aataataact acaccagaag atttttctag
     9841 tgttcgtgat gagttaaaag ctaaaggata tgagtttata tctgctgatg tgaagatgat
     9901 acctcaaact acaactgtat tgactgaaga atctcattta aaaatgatga ataaattagt
     9961 tgatatgctt gaagaagatg atgatgttca agatatatat cataactggg aagtagaata
    10021 aatagtataa gcatattgaa atttataagt attgaatcaa ttttaacatg tgataaattt
    10081 tatagaataa gaaacactaa aatagacata cgcacctcta acctatattt gcataataat
    10141 atgtaagcat aggtaagggg tgtttttata tttataggtt aagaaattta aagtaaattt
    10201 tgagctggac tcgattgtct ataaataatt gatgggtata taacttgttg ctgaatacca
    10261 tttatacgcc cagttactgt atcaataatc atcctaagac tacgttctgc tgtctcttcc
    10321 atttttaaat ctataactgt caaaggagga atacttcttg ccattagtcg tgaaggtcca
    10381 ttacttgctg caaatatttg aatatcctct ccaattacaa ttcccgattc atgaaatgca
    10441 ttcatcatac caagagctac cacatcatga ttacaaaaaa ttactttttt tagtgaattt
    10501 tttgcaagca ttttttgagc aatatcatat ccactatcta ttttattaga acaataatat
    10561 atagaatctg atagatgtat tccatgttct ttacatgttt ttaaaaaaga tttacccctt
    10621 aaagtcatac atgtaaagga agttgggttg aatacaacag caatatcatt tttaccattt
    10681 tgaatagcat gtaaagctgc tatacgacca gtttcctcat tatcaataga tacacttgaa
    10741 aaaccaggta tttcacgatt tacaacaact acaggaattt taggtttatt ttttactaga
    10801 tattctatat catcagcatt gatacctgtt aaaacaattc catcataata attatttgca
    10861 aaaaagtatt catcatcaca tagatgacca actttgtaag gtcgtatgat gatatttatg
    10921 tttaaatgtt ctaaagaaat tatgtggttt attgcttgaa gtatattggt tgatgccaac
    10981 tcaaatccct catcctgcca ataaaaagct attttaatat tattatgttt aataggagta
    11041 gagcgtttat atccaagctt atcagctgaa tttaatataa gctcttgtgt atgtagcgga
    11101 atcctgcgtt catttccttt accacttaag acgtacgaga cagttgctga agaaagacca
    11161 cagtcttttg caatatcttt gattgttgcc atgataaaat cctccttaaa tagttgctta
    11221 aatttgctta taccaataat cttaacatat attcaactaa agaacaatat tctacaaggt
    11281 gcatatttta caggattaga ataaataaat taaaaaaaac ttcttactta tgttgacata
    11341 atttagttta taggattata atatgcttaa ataagcttat gattaacttg aattaagcaa
    11401 agttaagcag gaacatgcaa tgctagcttg caatgtgact gcaaaggggg aaaaggtatg
    11461 agtaaggtaa atatatttga agttggtcct agagatggat ttcaaaacct gaaagagttt
    11521 ttagaaactg ataaaaagct taagattatt gatggtctta ttgcttctgg gattaaacaa
    11581 cttgaaatta gttcatttgt aagcccaaaa gcaatacctc agatgaaaga tgcaaaagaa
    11641 gtagcaactt attgtgtaga aaaatatcct gatgtgaaac tttatgcatt agttccaaat
    11701 ttatatggtg ctaaagttgc atgggagtgt ggtataagag atatatccta tgttatatct
    11761 ttgagtgaaa ctcataataa aaaaaatata aatcgtaccc atgaagagtc tattgatgag
    11821 cttaaaaaaa taatgaatac ttatccagac atgaatatat gtattggaat ggctactgta
    11881 tttggatgtc cttttgaagg tttaccaaaa attgaagatg ccataagatt tgctaaacgc
    11941 ctttgggaaa acggtatcag ggagataaat ctagcagata caatagggat tgctgaccct
    12001 aagcaagtaa gagaaactat tagtgcatta gttgaagctt taccagaatg cagatggcaa
    12061 gtacatattc atgatactag aaatatggga atggttaata ctcttgtggc tattgaatct
    12121 ggaattacta ctgttcagtc tacacttgga ggattaggag gatgcccatt tgctcctgga
    12181 gcatctggca atactgcaac tgaagattta gtatatatgc ttgaacgtat ggggtatgat
    12241 acaggagttg attttgttaa acttcttgaa ttatcaaaat atcagaagag ttttgtaaat
    12301 ggagtatata gtggtcatca tgtaaatata aagtctgata gttgtaattg ttagttctat
    12361 tgattaatcg attaaaaaaa tatgctgatt ggtaaaatag atttattgat aaaaaatata
    12421 aattataaaa tacattatct aataaaacaa ataaaaaaat tgagggggat tagtatggat
    12481 attatagctt tacttttatt tttaggagtt attattattg catttgtacg taagaataat
    12541 gcaggtattt tggctctagc tattggtgtc atagctgtta gaatttttgg aatggatgat
    12601 aaagaacttt atggagctat aagcaactca atgtttacta cacttgttgg tataacacta
    12661 ctctttgcaa tagtgaactc aacaggagca ttaaagcttg ttgcagaaaa aattgtagct
    12721 gcttctggta aacgtgtttg gcttatacct atagcagttt ttatagcagg atttgttgtt
    12781 gctggtgttg gacctggggc aattccagca cttgcaatta tcccagcaat ggctgttcct
    12841 gtagccataa cagttggtta taatcctgta atgcttgcac ttataggtga atgtggatta
    12901 atggcaggtc gtatgactcc tattactcca gaaggtcaaa ttataacaac cgttgcagaa
    12961 ggggttggaa ttgaaaatgt tatgcctact atcttagcct gtcaaactct ttctacaatt
    13021 gtattttcaa tagtattgtt tataattttc aaaggatata aacttaaaaa acctataaat
    13081 gttatagata gtaagcaaat agaaaaattc aatataaagc agataatttc tctaataagc
    13141 atagtagtta tgattgcttt tatcataatt tttgatatga atgttgggct tgcagctttt
    13201 gcagtttcag ctgtacttat ttttttcaat attgctgatg aaggagaatg tatcaaatca
    13261 attccatgga gcacgatagt aatggttctt ggagtaggtg caatgatgac aatcgtagat
    13321 gcagcaggag gtattgactt gatgagtaat gcattatcat cactgatgaa tagtaaaaca
    13381 gctactccaa ttatgagtat ttcagcagga cttatgtcta tggttagttc tgctttagca
    13441 gtagtttatc caactatgat gcctatgtgt gttgacatag ctaaggcagt tggaggagta
    13501 gacccactag cacttattgc tgcagttggt gttggaggtt ctcttgctgg tgtaagccca
    13561 ctttctactg gtggggcatt gattttagca gctatgggtt caagtaagaa agactttaat
    13621 aaggaagaac aaaataaggt ttttgtacag cttttcatta tgagtgcagt tggcttattg
    13681 gttattgcag tagtatcaat attatcattt aatgcaataa cacatttaat gaactaatta
    13741 gaataactga aaataaatca ttaaatttaa cttttaatat taatcaatat aatataattt
    13801 ggaggggaag ttatgaaaaa aggagcatta agcaatataa aggtacttga ccttacaaga
    13861 gttcttgcag gtccatattg tacaatgatg ttggcggatt ttggagctga tgttataaaa
    13921 atagagatgc caagaaaagg tgatgataca agaggttttg gaccttttgt aaatggagag
    13981 agtttatact atgcaaatat aaatagaaat aaaaaaggta tcactctaaa ccttaaatca
    14041 gaagaaggaa aaaatatatt tttagaaatg gtaaaacatg ctgatgttgt agtagaaaat
    14101 tacagaccag gtgtaatgga aaagttaggt ctgggttatg atgagttggc taaagttaac
    14161 aatcaaataa tttatggagc tgtatcagga tttggatgtt atggaccata ttcagaacgt
    14221 ccaggttatg atattattgc acaggcaatg ggtggtctta tgagtataac agggcaagaa
    14281 ggaggagaac caacgagagt tggtaatgct atgggtgatg tactaggtgg aatgaattta
    14341 actattggta tactcacagc actcaacgct agaaaaataa taggaaaagg acaaagagta
    14401 gatgtttccc tcgttgattc tgttgtatcg tctctcgaaa ctggtataca gagatacttt
    14461 gattcaggac aacctgaact tatgggtaat agatatgctt cagcctatcc ttatgactct
    14521 tttaaggcaa gtgatggaag ttttgtaata ggctgtggta atgacaaact ttttgaaaag
    14581 ttatgtaaaa aagttctttt tagagaagac cttttaatag atgagagatt taaaacaaat
    14641 cttaatcgtt gtgaacatta caaggctctt aaaccagaaa tagaaaaatg gtctgttaag
    14701 catacaataa aagaagcagt tgacttaata tcagaggctg gagttcctgc tgctcctatc
    14761 tataatcttg attgtgttac aacagatgaa catatagcaa aagcaagaga aatgattgta
    14821 gatattagtc atcctattat aggaaatatg aaagtcaatg gaaatccagt taagttgatg
    14881 acaacaaaag ctaaaattga tatgccagca ccatctctag gggaaagtaa cgaggagatt
    14941 tataatggtt ggcttggttt tgatagtgat aaaataaaag atttaaaaga aaatggagtt
    15001 atttgattaa aaaatagcta aacacacttg tgactttagt catgggaggt tcagttagaa
    15061 taatatcaaa aaatattaaa tcaatactgt aaataaaata tagaattgtc agaagcattt
    15121 aagatgggaa aagctactta gacattgagt ctttgtggct tttcctattt tcattaagaa
    15181 ttttatatta tcagaataga tatgtactaa actaaagtat taacaattta aattaataga
    15241 aaataaacta cctaattatg ttgaataaag actactttag tgaaaataaa cttatagaga
    15301 tgctatttaa attattttaa tggaaatatc aaaaatgaga ctgcattctc aaaaatgaga
    15361 ctgcgttttt taagtatttt ctcgaaaatg agacaaaaat attgttttat gggttttatt
    15421 gaagaaaaat tcttctgtga attacaattt aatcaatttt aaagttgaaa attattaaaa
    15481 atttagtgaa atttatgtat atttcgttta ttttattaaa aataacaatt ttttactaaa
    15541 aataaagaac ttcaatggtg attggcatag tacttgctat tttatattaa caagaaatgt
    15601 agaaaaaata acaatgtata atggggggaa tatgatggaa tctgtaatgg aaaatttgaa
    15661 caatcttaag gtggaggtta aggacaaagt ctgtgttatt actataaata gacctaaagc
    15721 tttaaatgct cttaatagtg acactcttag ggaactatca caagttattg atgtagtatc
    15781 agaaaatgag gcaatattag gagttattat tactggagaa ggtaaagttt ttgtagccgg
    15841 tgctgatata cgccagatgc aaaactataa aagtgaggaa ggcagaaaat atgcaggtta
    15901 tgctcaggga atttttgata aaattgaagc tcttgagaaa acagtaatag cagcagttaa
    15961 tggatatgca ttaggtggtg gatgtgaact tgctatgagt tgtgatatta gaattgcatc
    16021 agaaaaggct atatttggac aacctgaagt taatttagga gttattccat gttttggtgg
    16081 aactcaaaga ttatcaagac ttgttggaac tggaatagct aaagagttaa tttttacggg
    16141 gagacaagta aatgcagaag aagctaaatc tattggactt attaataaag tggttccaag
    16201 tgatttactt ttagaagagt ctatgaagat gatgaaccaa atagttgaaa aagcgccaat
    16261 agcaataaga tatgcaaaag ttgttattaa caaagggata gatatggatt taaagaatgc
    16321 tcttgaacta gagaaagatg ttgcaggttt aacttttgct acaagagata agcaagaagg
    16381 aatgaatgca tttatagaaa agagaaagcc agtttttgaa aataaatagc tattataact
    16441 aaaattggaa caatgtagaa tatattcaaa atctaaattt cgtgaaaaaa tacatatagt
    16501 ttaattttaa aaggagttaa tttatgaata cgggagtaat tataagttta gtagggatta
    16561 tcatagctct atctcttcta gttgtaatgg ttatgaaggg aataaatatt tttattatag
    16621 caattgtatg ttcatcatta gttgctataa caggaagcct aaatgtgtat gatgcactta
    16681 aagtggatta tatgacaggg tttgttggat ttcttcaggc aaatttcttt attttcctaa
    16741 cagggacatt aatgggaaaa ataatggaga ttactggtgg agcaaaatct attgctaaga
    16801 tgattgtaag atggattggg aaggataaag cactactttc tattccaata gcttgtggaa
    16861 tattagccta tggtggagta agtgttttcg ttgtaagttt tgcagtgttt ccgatagctt
    16921 tagaaatttt taaagaagct gatttgccac gaagatttat accagcagct ttgacttttg
    16981 gatgctcaac ttttgctatg gttgcaccag gggcaccaca aattcagaat attgttccag
    17041 catcaacatt agggacagat attatggctg gagcagtaaa tggttttata tcatgtgcag
    17101 taatgtttat agttggaagt acaattttgt acaaaatggt ttcaaaagaa aaagccaatg
    17161 gtggtcattt tatagcacat gaatcagata tatttgatga agcagaagca actaattcta
    17221 agagagaaaa tggtcccaat ggtgtaattg ccttaattcc attgatagtg tcgattttaa
    17281 taattaatgt aaaagttaat ggaaaagcga tagtaccaat tgaggtggga gtatttattg
    17341 gagctttatt agtatattta ttgttaaata aatatcaaga taatactaaa atagttggac
    17401 atgttggtga tgcatgtaaa actacagtag tagcaatatg taatacttgt gctgtagttg
    17461 catttggttc agtagtaaaa tcagcagttg gttttgactt catagttaat gctatgacta
    17521 atattcctgg tcctcctatt gcaggggctg cagttggaac tacagttatt gcaggtattt
    17581 gtgggtcagc ttcaggtgga ctaggaattg cagctccact tcttggacca gtatttttag
    17641 ccaagggtgt ttccgctgca gcattaacta ggactatggc aatttcatca gcagcattag
    17701 attcacttcc acacaatgga tatattgtta ctgtaacaaa tggtctttgt aaagaaacac
    17761 ataaggatgc ctatatgcca atattctggg taactgtttt aaccccattt attggaacca
    17821 tagtagcagt cctactgttt acaatgttcc cgggattgcc ataggagaaa agataaaagg
    17881 tataaattat attttgatat tataaaatca attttcaaaa tatatacaat aaatttcatg
    17941 ttttaatact gtaaatatgt atttaaaata acaaattgac catataagga ggaattgaaa
    18001 gtgttaaata aaccattaga gggagttaag gttattgacc taacgtattt tgtagcaggt
    18061 ccagggactt ctaaaatatt agctgactgg ggtgctgacg ttattaaggt agagccaagc
    18121 tttggagacc caggaagaaa gacaggggca acaatgacaa tgccaataga tgattataat
    18181 aatccttttt acagcacata taattcaaat aaaagaggtt tgtctataaa tcttaagagt
    18241 gaaactggaa ttgaaattat ggataagctt ttaagcgaag caaacgtatt tgtttcaagt
    18301 tatagaacag gagcattaaa aagactaggt cttgattatg aatcattaag taaaaagcat
    18361 ccacacctta tctggggtca gataaatggt tttggcgatt ttggacctgc taaggataat
    18421 gcaggatttg atacagttgc cttttgggca agaagtgggg ctatgcttga tatagcagaa
    18481 aaagatacaa gtccaataaa tccacctata gcctttggag atgcaacaac ttcttgtagt
    18541 ttatctggag gaatatgtgc agctttgtac cagcaagcta agactggaaa aggacaaaaa
    18601 gtaatggcat ctttatttgg gcaagcaata tggaatgcat catctttatt agcatctaca
    18661 cagtttagtg atgagtatcc aaaaactaga aaaaatgcta tttcaccagt aataaattct
    18721 tatcgttgta aggatggaaa gtggatattc ttaagtattt tagagcatga aagatatttt
    18781 gaggcacttt gtagattatt tggaagagaa gacttaataa aagaagagaa atttgcatct
    18841 tcagtagaaa gtaagaaaaa tgctacagaa cttattaata ttttagatgg tgaatttgca
    18901 aagtttactc aaaatgagat ggttgaaaaa cttactgctg ctgatatagc tcatgaaaaa
    18961 attcaacatg ttaatgatgt agtgactgat gaacaggcta ttgctaataa ctatatatat
    19021 gaacatacaa gtaaagatgg aaataagaca atgcttgcat ctactccagt taaatttgga
    19081 aatattgaag ttaacatgac ttgtgatgct ccacttatag gagaacattc agatgagata
    19141 ttgagagaac ttggatacag tgattctgat atagagactc taattgaatc tggaattgta
    19201 acaatgaata aagaagcatg tgaaatatgt taataaacat gtgaagtatg ttaataaata
    19261 ggagggaatt ttatggattt tagattaaca gaagcacaat taatgcttca aagagtagca
    19321 aaagaatttg cagagaatga aatagcacca atagctgctg aaacagataa aacaggtatt
    19381 tttccaaggg agctttttag caaaatggct aaaataggat ttaatggaat tggaacacct
    19441 gtagagtata gtggttctgg tggggcagat atagaaaagg taattgttgt tactgagatt
    19501 gccaaaaaat gtgcagcatc tgcagcaata ttatcaatac acacaatata tgctcaagct
    19561 attttgaaat ttggtactga ggaacaaaag aaaaaatacc ttccaatgat ggctgaaggt
    19621 gggtgtgtag gtgcttttgc cttaaccgaa cctaatgctg gttcagatgc tgcgagagct
    19681 gcaacaactg caattattga tgaagaaact gatgaatatg ttttaaatgg aactaagtgt
    19741 tttatttctg gtggaggtca agcagaatca ttaataatat ttgcattgac agacccatca
    19801 aagggaataa agggaatgtc tgctatcatt gtcgacaaag gtactccagg tttttcaata
    19861 ggaaaaattg aagaaaaaat gggtattcat ggttcagaaa ctgcagagtt aatatttgat
    19921 aactgtagag ttccaaagtc taacttatta ggaaaagaag gtaaaggatt taatatagct
    19981 atgacttgtt tagatggagc aagaattgga gttggagctc aagctgtagg aattgctgaa
    20041 ggggctttag aagaaagtat caaatattct aaagaaagag tccagtttgg caagccaatt
    20101 tcagctttgc aaggtattca atggtatata gcagatatgg cgacaatggt ggaatcagca
    20161 aaattattag tatattatgc tgcagatttg aaagctagag gagaaaaaca cactaaagaa
    20221 gctgctatgg caaaatacaa tgcgtcacgt actgcaagag aggttacaaa tttagccctt
    20281 caaatccatg gtggatatgg atatatgaag gattatccat tagagagaat gtacagagat
    20341 gccaaaataa cagaaattta cgaaggtact tcagaaatac acaaagttgt tatttcaaga
    20401 gcagtactag gataggagga aaagaatgaa tatagttgtt tgcttaaagc aagttccaga
    20461 tactaatgaa gttaaaataa ataaagagac aggtactcta ataagagatg gtgtaccaag
    20521 tataatcaat ccagatgata gaaatgcttt agaagaagct ctaaaaatga aagatgaact
    20581 aggagcagtg attaaggtta taagcatggg acctcctcaa gctaaaagtg ctttaaaaga
    20641 agctttggca atgggagctg atgaagctta tttaatctca gatagagctt ttggtggttc
    20701 agatacttgg gctacatcta caattattgc tgctgctata gagaaggttg gaaagtatga
    20761 tgtaatattc tgcggaagac aagctataga tggagataca gctcaggttg gaccagaggt
    20821 tgcagaattt ttagggatac cacaagttac ttatgcgaaa gaagtaaagg ttcaagatga
    20881 caaattacta gtaactcgtt atacagagac aggggattat ttaatagaag caaagatgcc
    20941 agttttatta actgctataa aagagttaaa caatccaaga tatccaagtg tcaagggaat
    21001 cttagaagct tataataatg gagatgcaaa gattactgta ttaacacttg cagatttaga
    21061 tgttgataca actcaaattg gattaaaggg ttcacctaca aacgtttata agtcttttgt
    21121 accagttaaa gacaagcata atgaaataat agaaggtata aataaaaaag aaaaagctga
    21181 gaaactaata gaaatactat tcgatttgaa actagtatag gagtgttaag atgatgagag
    21241 caaaagttaa tcaaggtata aatttaaatg attataatgg tgtttgggta ataggagagc
    21301 aaagggaagg taaaattaat cctgttacga tagaacttat tggtgaagga agaaagcttg
    21361 ctgaccaatt aggaaaagag cttgcagttg tgatagctgg atatgaagta gagaaagaag
    21421 tgaaggaatt acttcactat agtgttgata aagtatatta catcaatgac cctcttctta
    21481 aagatttcac tactgatgga tatgcaattt caattgcaaa tttaatcgaa agaaaaaagc
    21541 cagaggttgt attggttggt gctacttcta taggaagaga tatagcgcct agaattgcag
    21601 gtaaggttgg aacaggtcta actgctgact gtacaaaact tgaaatagat tcaacagata
    21661 ataagttatt acaaacaaga ccagcatttg gtggaaattt aatggccact attgtttgtc
    21721 caaaaaatag accacagatg tcaacagttc gtccaggagt tatggcaaaa gctgtaagaa
    21781 acgaatcaga gactggaatt ttagaagttg ttactccaga acttactgaa aaaatgatta
    21841 gaactagatt agtagagata cttccacaag aaaagaaatc tgtaaatcta actgatgcta
    21901 gaataatagt atcaggggga agaggattaa aaagagcaga aggatttgag cttataaaag
    21961 aattggctga taaattgggg gcagagattg gtgcttcaag agcagcagta gattcagggt
    22021 ggatagaaca ttctcatcaa gtgggacaaa caggaactac tgttagacca gaactataca
    22081 ttgcatgtgg aatatctgga gcaatacaac atttagcagg tatgagtgat tctaaatata
    22141 tagttgctat aaataaagat gcaaaagccc ctatttttag tatatgtgac tatggaatag
    22201 taggagattt atatgaaatt atacctgaaa tgatagaatc attaaatagg taacttttag
    22261 aaaacattga atatgtagaa tgataagtct tataatattg tattgtaaga cttattattt
    22321 ttgctgaagg ttatagtggg gagatgaaac aatgaaagag cagtggtata aggatatatt
    22381 tgcaagagta ttatctatga ctgatgatgg ttttattgtt gtaaatacaa gtggagtaat
    22441 aatagatatt aatgataaat attgtgactt tttaggaaaa gaaagaaaag atataatagg
    22501 acaaaatata caaagtatta taccaaatac aaaaatgcta gatgttatga aaaataagta
    22561 ttgtgaagaa ggagctatac atcattattc aggtggaaat acaaaagaaa aaagtgtaat
    22621 agtaagtagg tcttatgtgg aaaatgacaa tggagaagta gttgcaggag tagctcaagt
    22681 taaatttaga ttgcaatcat ttgatgtagc taaaaagtta atgtcagaat atatggagct
    22741 ccaatattat aaagagcagt ttaaggataa ctgtggtttt gacaagctca taggtgaaaa
    22801 tagagacttc atagaactta agaaaacagg tgtgaaagct tctaaaacaa actttccagt
    22861 acttttaacg ggtgaaacag gcacaggtaa agaagttttt gctagagcaa ttcacaataa
    22921 tagcagtagg tcagataaac ctatggttag tataaattgc gctgcaatac cagaagaatt
    22981 attagagtca gagctatttg gctatgacga aggagctttt acaggagcaa aaaagggtgg
    23041 taaaaaaggt aaatttttag ttgcgaataa tggtacaatc tttttagacg agataggtga
    23101 catgcctttg accatgcaag caaaactttt aagagttctt caggaaagtg agatagaacc
    23161 agtgggaggt cttaaaacta taaagataga tgtaagagta atctctgcca caagaaagaa
    23221 tttaagtaaa atggttgaag agggattatt tagagaagac ctatactata gattaaatgt
    23281 aataaacatt catatgatgg aattgaagga caggcaagat gatattttat tgctagcaaa
    23341 ttatatatta aacaaattaa atgttgaata caaggaattg aaggttttaa gtgataaggt
    23401 taaaaattgt tttattaact atacttggcc gggaaatata agagaactac aaaatgtaat
    23461 aaaaagtgcc tatgctgtaa gtgatgatat ggtcattatg atgtgtgacc ttccatctaa
    23521 gatggataat atcagcagag tagctcaatg taatgtggat agcaattgtt caattcatga
    23581 aatggttgag aattatgaaa agagcttaat tattgatgtg ttaaggaagt ataattggaa
    23641 atgttctaag gcagcagagg ttatgggaat acacaagagt cttttatata agaaaataaa
    23701 aaagtatgaa attgaattaa ataattaaga taacttgaat taaggcaatg ctaaaaaagc
    23761 gcccttattc aaagcgaact gtataaactg ttttatgcag ttaaaacgtg taaaagtaga
    23821 tgtgaagtac taatgtcaat cattagtact tttttattat atttataatt actatctata
    23881 tttcagtatc ttttgatatc taagattatt atgtttaatt tagtatataa caaaaccctc
    23941 ttagttatgg acagtttttt atattttaac tgtctactaa gaggggatag tttagtttaa
    24001 atttagagta aattttatct agcatttata aaaaatattt tgaatagctt ttttgttatt
    24061 tagtcataat tttctacttc tttatcaagt tctttgccac aagaatcaca cttatatata
    24121 gcattgtatc cgtaatcata ttcatcaact attttctttt gtctaaatac accaccacac
    24181 tcacatagga aaccaatttt tataagtgta acgataaatt gtgattttat aaattttata
    24241 tcattgcatt tatcgttagt gtaaaatgta taaatataag agttatcgca ctcatctctt
    24301 aattcaaatc tttcaatata tgtgttattt tttaattcct caaattcttc tttagttaaa
    24361 tatgattttt gttgcaattc atgtaaacgc ttaatttggt ccattattta tatcctccca
    24421 ataattttag tattttaagc ttagataagg aatctaagtt ttattaaatt tatcccaagg
    24481 aattatttaa atcatattta gttttattaa ttacaacata tataaattac acgaaaataa
    24541 aactaattgt aaaaataata tcctgtgaaa acctaaacta ctaacccctt actaacccga
    24601 aaactaaaaa aagaaaatat atccaaatat aagtgatata taaataaaga
//
LOCUS       DAEHWM010000057        24632 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.058, whole genome shotgun sequence.
ACCESSION   DAEHWM010000057 DAEHWM010000000
VERSION     DAEHWM010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24632)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24632)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24632
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.058"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            545..1873
                     /locus_tag="KNP36_002328"
     CDS             545..1873
                     /locus_tag="KNP36_002328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0874194.1"
                     /translation="MGSNELKKTLGVSAALSTVVGSVIGAGVFFKPQAVYTLTGGAPG
                     LGILAWLIAGIITITAGLTAAEVSVAIPKTGGMMVYIKEIYGEKLGFLTGWMQIVLFY
                     PGMMAALGVIFGEQASALIGSPSLLLPIAIGIIIIVAGLNMLGSKTGGVIQTVSTICK
                     LIPLILIMVVGFIKGGGNNPILTPMVGEGLSLGSVLGQVLIAILFAFDGWMNVGTLAG
                     EMKNPGKDLPKAIIGGLSVVMAVYFIINLAYLWVLPANELANYASPASAVAEVIFGSM
                     GGKIISVGILISVFGALNGFLLTGSRVAYTLATDKTLPKYGIFSKLNSAQVPANAIAL
                     VSVIASIYALSGQFNLLTDLAVFATWIFYVLTFIGVMKLRKTHPNIPREYKVPLYPIV
                     PIIAIASGIFVVVNQLCFAGMKTTMISIGGLVITAIGLPVYAYMTRGVKR"
     gene            2626..3459
                     /locus_tag="KNP36_002329"
     CDS             2626..3459
                     /locus_tag="KNP36_002329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="HBF0874195.1"
                     /translation="MRNKKKKINRKKLYLLLSAIVVCLAFIVVGVRVSSLNMKENEIS
                     RNAKLSSSTITDIVSNTSIEVSKGPSKSSGKIAYITIDDGPSKFTDQMIKTLNKYNVK
                     ATFFMIDGNMKEYPQQVKNIIKNGNTAGFHSVSHDIHKLYVTSTSAKEEFDTNDQTFY
                     KITGKHSKVIRIPYGSKPYTPQASYQALVDAGYKIWDWDLDTEDWRSNSSQIVQNVKN
                     HIKNRKGEDKDQLVVLMHEKKQSAEALDSVLKFLSDEGYEFAPVDQNQIPKNYWLRNL
                     E"
     gene            3552..4484
                     /locus_tag="KNP36_002330"
     CDS             3552..4484
                     /locus_tag="KNP36_002330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBF0874196.1"
                     /translation="MVGILSLMMVGCNKSLAKVNDVEITKEQYKKTKAVLSATNNYIN
                     GQSLDELEKTLDKKGRNKLENVIISFMVDNELLYQEAKDKGLTPSKSEVDSKYQELED
                     KMNLNTSYKEKMDKAGVDKDYLKQEISRDLAIDKNKKAFEDRINISDNDMEAYYTSHK
                     KDFNVEEVSASQILISTLDKNKKEVSKDKKEALKKKADNILTKIKNGESFESLAKKYS
                     DDKATGKNGGQLGYFTKDDKNAEFTKEVFKLKKNEVSNVFETSYGYHIVKVTDKRERQ
                     KSFNECQSLIRESILNEKYIEHIKKLNEDAKIDR"
     gene            4536..5018
                     /locus_tag="KNP36_002331"
     CDS             4536..5018
                     /locus_tag="KNP36_002331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0874197.1"
                     /translation="MFKSLKRTKVEKYIIDNKDSFYRIAYSYTKNEEDALDVVQEAMY
                     KALYSVENIKEVNYIKTWFYKILVRTSIDFIRKNRKYNNMTDIDLIDETGEYDKYTDL
                     DLRRALEELPIEYKSIIILRFFEDLKIEEVAIILDENVNTVKTRLYTALKKLKLKIEE
                     "
     gene            5030..5899
                     /locus_tag="KNP36_002332"
     CDS             5030..5899
                     /locus_tag="KNP36_002332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBF0874198.1"
                     /translation="MTSKERLNKLKDEYHKIPIPKKLDTIINHEKIENIYREKNKKVN
                     RLRFKVAIAFACIFTVLVNISPVFADNFSKIPVIGAIVEVITIKNYSLKSENYEAEID
                     IPKIRGLKDKNLEQRLNSSFMEDGKRLYHQFQERMEKIQSSKNKGYKSLSLSYSVKNN
                     SKKFLSIEMTKNEIEASSYVSKVHYTIDKKRQIVLTLPMLFKDDKYIKVISDNIKEQM
                     REQMKKDSTKSYFIDQKKDLPVEDFKTINKYQDFYFNKNEDLVICFDEYEVAPGYMGA
                     VEFVIPYKVIKDL"
     gene            5942..6697
                     /locus_tag="KNP36_002333"
     CDS             5942..6697
                     /locus_tag="KNP36_002333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3298 domain-containing protein"
                     /protein_id="HBF0874199.1"
                     /translation="MTTYKKLKKSIFKIAIFSICLLASLVDTNPIFAGSSFNETSNSD
                     TIKVLNAKSINFKQDNYEVNVSIPKIKGLKDKTLENKLNNEFLQDGKKIYSEFQNKMK
                     KEDNKGHRYLNVIHNVKNNSKDFLSIEMTKEEIEASSSITKKHYTVDKNRGILLNLPI
                     FFKDSRYIRAISDNIKEQMRNQIKKDDTKSYFIDQDKDSPVKDFESINKYQDFYFNKN
                     GNLVISFDEYEVAPGYMGAVEFVIPNKVIKRLR"
     gene            6739..7560
                     /locus_tag="KNP36_002334"
     CDS             6739..7560
                     /locus_tag="KNP36_002334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine dehydrogenase accessory factor"
                     /protein_id="HBF0874200.1"
                     /translation="MNIYEQAIRLIENNEDFAFATITSHSGSTPRETGAMMIVKNDST
                     IFGSVGGGSVEAECIKHAINVIKNRESMLYKFTLNKSDVAKLGMICGGTGEIQIDFID
                     SKLKSNIEKFNKRLKENTSKAYIFGAGHISRDVAVILSLLEFRTVVIDDREEFANHER
                     FPESEVVVLDSFENIPDFPTDENSYIIILTRGHLYDSSALEWALKREAGYIGMIGSRT
                     KIGLTYEKLMKKGFKKEELSKVHAPIGIKLNAQTPAEIAVCIAAELINCRANKEK"
     gene            7565..8326
                     /locus_tag="KNP36_002335"
     CDS             7565..8326
                     /locus_tag="KNP36_002335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M48 family metallopeptidase"
                     /protein_id="HBF0874201.1"
                     /translation="MNTGSKDIDTLKVNFRGIEIKAVLVYKNRKNISIKIDPFGKITV
                     MSPPKISKKIIKDIIIEKGDWILKKSEKCKGREEVYKQRMFITGEKFLYLGEEYHLVI
                     KELLRDSVKKSNCRITINEYQIVVQTNDTSTDFIKKSLKSWYKMESERIVLERIDFLK
                     LNCEIMKQLVPASVKVKEQNKRWGSCTAQKNIYINSKISMARLDVIDYVIIHEFSHLV
                     HMNHSKKFYDLVKSIMPDYKDKENWLKINGYKIII"
     misc_binding    8487..8744
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            8857..9096
                     /locus_tag="KNP36_002336"
     CDS             8857..9096
                     /locus_tag="KNP36_002336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBF0874202.1"
                     /translation="MENTVYAKLNQGIDSFLRVAMTLRRREVDIQSISMTVDNMNNSG
                     IKLIVNEEKTSLDSVLNHMKKLHDIREITVERMRH"
     gene            9400..10395
                     /gene="ilvC"
                     /locus_tag="KNP36_002337"
     CDS             9400..10395
                     /gene="ilvC"
                     /locus_tag="KNP36_002337"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HBF0874203.1"
                     /translation="MKMARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVH
                     VVIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMMLMPDEKQKKVYEESVKDNLKE
                     GQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDYT
                     KKATETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVD
                     AGYQKEVAYFECLHEMKLIVDLIYEGGFERMRYSISDTAEYGDYVSGKRVITDVAKQG
                     MQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRNLRSMMSFLK"
     gene            10448..12136
                     /gene="ilvB"
                     /locus_tag="KNP36_002338"
     CDS             10448..12136
                     /gene="ilvB"
                     /locus_tag="KNP36_002338"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biosynthetic-type acetolactate synthase large
                     subunit"
                     /protein_id="HBF0874204.1"
                     /translation="MNGAKVILECLKKEGIDTIFGYPGGAVIPLYDALYDYSDDFKHI
                     RTSHEQGLVHAADGYARSTNTVGVCFTTSGPGATNAITGIATAFMDSSPMVVISGQVP
                     TSLLGKDSFQEIDITGATLSMTKHNYLVRNTKELVPTIKEAFRVANSGRKGPVLVDVP
                     KDLFLAEMDFSGEDYDLCQIDDYMDYKSDFDLDDETNIKLLNEAIDIIKESKKPIIYA
                     GGGVKSSDSEEILEKFATKIDTPVLNTLMGLGNIDRKNELSLGMVGMHGSRESNLALS
                     NSDLVIAIGARFSDRVISKSSEFAKNAKIIHIDIDPSEISKNIESNVSLVGDVKLVLS
                     LLIERVESKNNSNWKEEIKRFRKSEGVQTYEFHPQNILKKINEKYETLKKPTVVVTDV
                     GQHQMWAAKYWNFKGNKSFITSAGLGTMGFGLGAAIGTKVGNVDKNVVLVTGDGSFRM
                     NCNELATVANYNVPMLILLLNNRTLGMVRQWQKLFSNQRYSQTDINENVDYVKLVNAY
                     NIDGYKVSSMEELGKALDMIDFNKPVFLQCDIDKDYDVYPIVAPNDALENLICN"
     gene            12347..13024
                     /locus_tag="KNP36_002339"
     CDS             12347..13024
                     /locus_tag="KNP36_002339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBF0874205.1"
                     /translation="MFKHDKALLKEVKVERPNPQYAVLMQEQLGGANGELKAAMQYLS
                     QSFRIKDPQIKDLFLDIAAEELSHMEMVAQTINLLNGHDVDYNAVNTGEIETHVLTGL
                     SPVLINSSGAPWTANYVTVTGDLVADLLSNIASEQRAKVVYEYLYRQIDDKYVKETID
                     FLLNREEAHNALFRDALNKVKDTGSNRDFGVTEDSKLYFDLSTPGPNHDTKIDINPPS
                     FEKPLKK"
     gene            13193..15229
                     /locus_tag="KNP36_002340"
     CDS             13193..15229
                     /locus_tag="KNP36_002340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin domain-containing protein"
                     /protein_id="HBF0874206.1"
                     /translation="MDSNRKPNNLINEKSPYLLQHAYNPINWYSWNDEAFKKAKEEDK
                     PIFLSVGYSTCHWCHVMEKESFEDEEVAEIMNRNFVAIKVDKEERPDVDSVYMTVCQA
                     MTGSGGWPMTIIMTPDKKPFFAGTYFPKYSRYNRPGVIDLLENVSEKWNTSRDILIKS
                     GDEIIEALKDDFGVKNTEGDLSKEMLSSSVRVFKAIYDEKYGGFGNAPKFPSPQNLMF
                     LMKYYSIEKDKDVLKMVEKTLDGMYRGGLFDHIGFGFSRYSTDKKWLAPHFEKMLYDN
                     AMLTIAFLDAYKITKKELYKEIAIKTIDYVVREMKDKEGGFYSAQDADSEGEEGKFYT
                     FNPLEIIEVLGEEDGIFFNNYFDITSSGNFEGKSIPNLIKNKEYERHNEKIADLSKKV
                     FEYRKERTSLHKDDKILTSWNALMIVALTKAYSTLKNDIYLEYSNKCLNFINNNLVNE
                     SGRLLARYRDGSSDYLAYLDDYAFLIWAYIELYESTFNMKYLEKALNLNESCINLFWD
                     YEKSGFYIYGKDSENLIARPKDLYDGAIPSGNSVQLYNLIRLAKITGDNRLEEMSYKQ
                     LKLYVDNVKSSPAGYSFYMLSLMFELYSTKEIICIFKEDSDLIAFKELISENFIPNAT
                     FLAKKYNEENTIIGFLNNYRLKDDKISYYVCQSNSCSQPINDLQKLKDMILGVE"
     gene            complement(15420..15986)
                     /locus_tag="KNP36_002341"
     CDS             complement(15420..15986)
                     /locus_tag="KNP36_002341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0874207.1"
                     /translation="MDYSNELKELFLMNQTYATLFTLTNKIQIEGDKYFGILTSRQYM
                     TILSILHLPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKV
                     TDLGKKVMVTCSRTGINFMADVFHEFTKDELETLWSLLKKMYRFNGEEQDGFEEDANF
                     MEYEEIDKIKSEALEEFAKRRKRVNKND"
     gene            16274..17209
                     /locus_tag="KNP36_002342"
     CDS             16274..17209
                     /locus_tag="KNP36_002342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0874208.1"
                     /translation="MKCTNFTFKGEEGLDIYTYKWEDENIKKPKAVIQIAHGMAETAQ
                     RYETFAKVLTKNGYIVYINDHRGHGKTAKIIENVGHLAEKEGFRCLVEDMYTLTNIIK
                     KENEDLPIYLFGHSMGSFASQRYIMDYSNNLSGLILCGSNGKQGIILNLAHLIINREI
                     KKYGRRSKSNKINNLIFGGEIIRRNEKTKFDWLSRDKEQVEKYINDPFCGVVCSCGFF
                     YDLVQGLKEIEDKENLKKVPLDIPIYIISGDKDPIGKNGKGVLRLRDRYIKLGVKDVT
                     CKLYKDGRHELLNEINREEVFEDIICWLNNKIEIL"
     gene            17674..18888
                     /locus_tag="KNP36_002343"
     CDS             17674..18888
                     /locus_tag="KNP36_002343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874209.1"
                     /translation="MQIKIGKVIQCLRKERNLTQEQLAKFIGVSTPAVSKWESGNSYP
                     DIELLPLLADFFNVSIDKLLNYKIDLSEEEVMKIYKELESGFARIEIDLSTEEPKEEF
                     RQDLESVKKLSNMYIEKYPKSYLLKLRICSLYQMYSYKFGKSELNDRVKETTNILEDI
                     VRNTDDIQIKETALIILSNAYCMLEDYEKAELYLNMIHKSIGDTSVNLAMIYLKQNRL
                     EEAEILLQNKLFSNVFNISMDCKGIINVYKNQYKELKKKLENRNFNKNAIEREMEYIK
                     NKLLGYANLSLEIKKMLSEDKGAFFSMYMDYMELSLIFLFFNMKEEAKKALYSLKEIL
                     EKYPIHESLDVSQMRFFDKVESKNLYTFNIYTNLLIVLNDDSYNELREEPIFKDVIEK
                     ILDMEKMLKNKE"
     gene            complement(19308..19829)
                     /locus_tag="KNP36_002344"
     CDS             complement(19308..19829)
                     /locus_tag="KNP36_002344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0874210.1"
                     /translation="MKFERLRTSENKLYYKAMELYKISFPFHKQRKSSLQAEILKNKE
                     YQFNLIYDKNQFVGIILCWETDNFIYVEHFCIFPEIRNNRYGQRALELLNKKGKTIIL
                     EIDLPIDEISIYRKAFYERVKYKTNNYEHIHPPYHKKFNGHNLIVMSYPEKLSKMEYD
                     KFNHYLRNNVMSF"
     gene            20185..20982
                     /locus_tag="KNP36_002345"
     CDS             20185..20982
                     /locus_tag="KNP36_002345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HBF0874211.1"
                     /translation="MEKREKRIIISSLLSVSILMGLASIYSILNKEDISLTVKGQEQK
                     VSSFKKTVEELLDEQGVKYNSEDKINPSLDTELKDDMKIKVVKVTKSKKEEIEKIPFD
                     TKHVNDSNLLKGKSKVYQEGQEGEKKLVYNLTYHDGKLVKKVLSKEVISKEPTTKIIK
                     YGTKEKVLIASRGANIRGGKHMKVVATAYAGDTITSTGTTPRWGVIAVDPRVIPYGTK
                     VYIPKLGMTFVAEDCGGAIKGNRIDIFMNSEGKASNWGRKSIDIYLH"
     gene            21092..21682
                     /locus_tag="KNP36_002346"
     CDS             21092..21682
                     /locus_tag="KNP36_002346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="HBF0874212.1"
                     /translation="MKIVCLGDSLTYGFGVSRSNSWTNIVNKETRLEIVNKGINGDTT
                     SGMLARFNEDVVKNSPDIVFIMGGTNDFIAGAGNEIINSNIMAMVHQSYSKNIIPIIG
                     IPLKPDIPNVREDWSCFTDFNIVSQNLESYSYWIKKFCMTFNTNFVDFYSEYNKNMEL
                     EGYKKLYFDGLHPTKEGHRIMADIFINSINKYIEEL"
     gene            21748..23445
                     /locus_tag="KNP36_002347"
     CDS             21748..23445
                     /locus_tag="KNP36_002347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HBF0874213.1"
                     /translation="MDYTKTYEEWIKGSYFDEDTKLELENIKNNEKEIEDRFYKDLEF
                     GTAGLRGIIEAGTNRINKYTVRRATFGLANYILENTTKEETSRGVVIAHDNRHKSRQF
                     CIESANTLAACGIKAYIFDSLRTTPELSFAVRSLNAIAGIVITASHNPPEYNGYKVYW
                     EDGAQVMPEIANAITEKVNSIHDYSTIPTLTEANKNLVVLLDESQDTKFIEAVKSQII
                     RKDLVKNVGKSFKIVYTPLCGTGNVPIRRALKEVGFENIIVVPEEENPDPNFAGLDYP
                     NPEEKKALNRGILLAKEKGADLVIATDPDCDRVGVAVKTTTGEYALLTGNQIGGMLTH
                     YIIEGLKENNKLKENPTIIKTIVTSEFGADIAKANNVDVLNVLTGFKFIGEKIKLFEQ
                     NKNRSYVFGYEESYGYLVGTHARDKDGVVSSLLISEMAAFYYSKGMSLYDGLIELYKK
                     YGFFKEQTISLTLKGIEGVEKIKEIISYFRENQIDYINSIKVVDKKDYKNGIDNLPKS
                     DVLKYFLEDESWVAIRPSGTEPKLKFYIAVKGASDIEADKKIQGLKKYIDDMVEKLK"
     gene            23659..24498
                     /locus_tag="KNP36_002348"
     CDS             23659..24498
                     /locus_tag="KNP36_002348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HBF0874214.1"
                     /translation="MFGIDKKLIEYIIAKSNYSELSSKSAEVSFFLMLSIFPFLIFTI
                     SSIAYIPILHLNKYIALFRNMMPEGAFAVLSSIIVSAIDNRNLKFLAVSFVLTMWTFS
                     RAVKALIKGMNRAYKVKETRSFFKILSISFLFTIMLLVLIFLSMIFLVYGEKIGYFIF
                     NLVGLDEIFIKIWDILRYTVGIITIIVIFTLLYKYTPNKKLTIKESAPGAIFATFAWF
                     LVSFLYSYYTNYYANYEVIYGSIAEIIVLMTWMYFSSWSIVIGYEVNSRLYFRKIRHE
                     MLK"
BASE COUNT         9957 a         2435 c         4217 g         8023 t
ORIGIN      
        1 aaaaaacata tttagatttt aacatctcaa aggagttttc aaagctaata tttcattttt
       61 aaataaaaaa ataaaatatt agttttgatt tctggtttaa attgggttat aataaattgt
      121 caaattattt attaatataa aatagactat aaaacaagca aaaatcatac tattatataa
      181 aagaccttaa agatagaaaa ctacagaaag aagccaaaat gtttttgaaa aaaatgaaat
      241 tttattgcaa aaaaatcaaa atgaatttaa cttaatagtt ataatctatt tttagtgtta
      301 caaatataca atgtatatta tacaatataa aaaatacatt tacttagaag tattattata
      361 tttggatttt tggtttttat aattttttta tatttaaaca taactaaaaa taaaagatta
      421 ctaaagctaa gtagagttta ttttatttta ataaataata aagctatttt tctatatatt
      481 ggcataatat atgcttattt aactatgaaa ttaaaattaa ataggattaa tgaggaggaa
      541 aaaaatggga agtaatgaac tgaaaaagac tcttggcgta tcagcagcat tatcaactgt
      601 tgttggttcc gttataggag cgggcgtatt ttttaaacca caagcagtct atacattaac
      661 tggaggagct ccaggtcttg gtatattggc atggttaata gctggaatca taactataac
      721 agctggtctt acagctgcag aggtatcagt tgcgatacca aaaactggtg gaatgatggt
      781 atatataaaa gaaatttatg gagaaaaatt aggtttttta actggatgga tgcaaattgt
      841 attattttat ccagggatga tggcagcatt aggtgttata tttggagaac aagcatcggc
      901 actaattggt agtccatcac ttttacttcc aatagcaatt ggaattataa taatagttgc
      961 agggcttaat atgttaggtt caaaaactgg aggagtcata caaactgttt ctacaatttg
     1021 taagttaata ccacttattt taataatggt tgttggattt attaaaggtg gtggaaataa
     1081 tccaatactt acacctatgg ttggtgaagg attaagcctg ggtagtgtac taggtcaagt
     1141 tttaattgct atattatttg cttttgatgg atggatgaat gttggtactt tagctggaga
     1201 aatgaagaat cctggaaaag accttccaaa agctataata ggtggattgt cagttgttat
     1261 ggctgtttat tttataataa atttagcgta tctttgggta ttaccagcta atgaattagc
     1321 aaattatgct tctcctgcat cagcagttgc tgaagttata tttggttcaa tgggtggaaa
     1381 aataatatct gtaggtatat taatttcagt gtttggagca ttaaatggat ttttactaac
     1441 tggttcaagg gtggcatata ctttagctac agataagact ttaccaaagt atggtatatt
     1501 ttctaaatta aattctgctc aagttccagc aaatgcaata gcattagtat ctgttattgc
     1561 atctatatat gctttgtcag gtcaatttaa tttattaact gacttagctg tatttgctac
     1621 ttggatattc tatgtattaa cttttatagg ggttatgaaa cttagaaaga ctcatccaaa
     1681 tataccaaga gagtataaag ttccattata tcctattgtt cctataatag ctatagcaag
     1741 tggtatattt gttgtagtta atcaattgtg ttttgcaggt atgaaaacta ctatgatatc
     1801 tataggaggt cttgtaataa cagctatagg cttaccagtg tatgcttata tgactagagg
     1861 agtaaaaaga taaaccaagt agtttacaaa tgcttcataa ttaaaataaa agagactgtc
     1921 tcaaatagag ataagtctct tttttattgt taaaatggta aagatatgtt taattttaca
     1981 aaaaaagagc gttccatgaa ctaaaaagtt tattttaagg tattcatttt atttttagtt
     2041 ttttgattat aaaattaaac atctaaaaaa ttatttattt taaaatactt tattttaaag
     2101 tgttttttat caaactaagt ggtatctgta caacaaatat tatacatagc ttttatgaaa
     2161 attaaatctt tctgttatat ataatagaat attgtattat atagaaaata ttacctgatt
     2221 aatatagtga tttataaatg agattagaaa attttatttg ataacaaaaa ttagataata
     2281 tgaatatata atgtatgtat taaaaatgtg gcaaatagtt gttttgctat ttattatttg
     2341 tttaatattt ctaatttata aaaaaaaaat tataaatttt aaaaattata aatgacattt
     2401 taactagaat taattgtaaa aaacactata taatactcaa ttttcaacat tctatacaat
     2461 tatacagaaa ttatacagca taataatcac cgaaataaca aattttaaaa attaagcaaa
     2521 actttttgtc gaagttcaac gtctatatat atgtagtgta aatttttggg ataaaatact
     2581 acaaaaatat aaatgtaaaa atatagtaat attggaggtc gaacgatgag aaataaaaag
     2641 aaaaaaataa atagaaagaa gttgtatttg cttttaagtg ctattgtagt gtgtctggct
     2701 tttatagtag ttggtgttcg cgtcagctct ttaaatatga aggaaaatga aattagtaga
     2761 aatgcaaaac tgtcaagttc tactattaca gatatagtat ctaatacatc aatagaagtt
     2821 agtaaagggc caagtaaaag ttctggaaaa atagcataca taactataga tgatggtcca
     2881 tctaaattta ctgaccagat gataaaaact ttaaataaat acaatgttaa agcaactttt
     2941 tttatgatag atgggaatat gaaggaatat ccacagcaag ttaaaaatat aattaaaaat
     3001 gggaacacag caggttttca tagtgtatca catgatattc acaagcttta tgttactagt
     3061 acatcagcaa aagaggaatt tgatacaaat gatcaaactt tttataagat aactggtaaa
     3121 cattcaaaag taataagaat accttatgga agcaaaccat atacaccaca agcctcttat
     3181 caggctttag ttgatgctgg atataaaatt tgggactggg acttagatac agaagactgg
     3241 agatctaatt cttctcaaat tgtacaaaat gtaaaaaatc atattaagaa tagaaaaggt
     3301 gaagataaag accaacttgt agttttaatg catgagaaaa aacagagtgc agaagcttta
     3361 gattcagttt taaaattctt atcagatgaa ggttatgaat ttgcgccagt agatcaaaac
     3421 caaataccaa aaaattattg gttacgtaat ttagagtagt taaaatataa gaatattgat
     3481 tgatattttt agaaattgag aataaaaatg agtgaggtgt aggtatattg aataaaaaac
     3541 tttatatagg aatggtcgga atattgtctt tgatgatggt tggttgtaat aaaagtttag
     3601 caaaagtaaa tgatgtggaa atcacaaaag aacagtacaa aaaaacaaaa gcagttttat
     3661 ctgctactaa taattatata aatgggcagt ctttagatga attagaaaaa actttggata
     3721 aaaaaggtag aaataaatta gaaaatgtta taatatcgtt tatggtggat aatgaacttt
     3781 tatatcaaga ggctaaggat aaaggactaa ctccaagtaa aagtgaagta gactcaaaat
     3841 atcaagaact agaagataag atgaatttga atacaagcta taaggaaaaa atggacaaag
     3901 caggtgttga taaagattat ttaaaacaag aaatatctag agatttagca atagataaaa
     3961 ataaaaaggc ctttgaagat agaataaaca taagtgataa tgatatggaa gcctactata
     4021 caagtcataa aaaagatttt aatgtagaag aagtaagtgc ttctcagata cttatatcga
     4081 ctttagataa aaataaaaaa gaagtaagca aagataaaaa agaagctttg aagaagaagg
     4141 cagataatat attgactaaa atcaaaaatg gagaaagttt tgaaagtttg gctaaaaaat
     4201 attcggatga taaagcaact ggaaaaaatg gaggacagct aggatatttt acaaaggatg
     4261 ataaaaatgc tgagtttaca aaggaagtgt tcaaattaaa gaaaaatgaa gtttcaaatg
     4321 tgtttgaaac tagttatgga tatcatatag tcaaagttac tgataaaaga gaaagacaaa
     4381 aaagttttaa tgagtgtcag agtttaataa gagaatctat tttaaatgaa aagtatattg
     4441 agcatataaa aaaactgaat gaagatgcta aaatagacag atagaatttc taacagctca
     4501 atcctagcct gtaatcggag ggagatttta caggaatgtt taagagttta aagagaacga
     4561 aagttgagaa atacattatc gataataaag actcttttta tagaatagca tatagttata
     4621 cgaagaatga agaagatgcc ttagatgtgg ttcaagaagc catgtataag gcactatact
     4681 cagtggaaaa tattaaagaa gtaaattata taaagacatg gttttataaa attttagtta
     4741 gaacgagtat agattttatt agaaaaaacc gtaaatataa taatatgaca gatattgacc
     4801 ttatagatga gactggagag tatgataaat atactgattt ggatttaaga agagctttgg
     4861 aagaattacc tattgaatac aaatctatta taatattaag attttttgaa gatttaaaga
     4921 ttgaagaagt agcaataata ttggatgaaa atgtgaatac tgttaaaact aggttatata
     4981 ctgctttaaa aaaactaaaa ttaaaaattg aagagtaggg ataaaaagaa tgacaagcaa
     5041 agaaaggtta aataagttaa aagatgagta tcataaaatt ccaataccca agaaattaga
     5101 tactataata aatcatgaaa aaatagaaaa catatatcga gagaaaaata aaaaagtaaa
     5161 tagattaaga tttaaagttg caatagcctt tgcatgtata tttacagtat tagtaaatat
     5221 aagtcctgta tttgcagaca atttttctaa gatacctgta attggagcaa tagtagaagt
     5281 aataactata aaaaattata gtttaaaaag tgaaaattat gaagctgaga ttgatattcc
     5341 taaaatacga ggtttaaaag ataaaaactt agaacaaaga ttaaacagta gttttatgga
     5401 agatggaaaa aggctttatc atcaattcca agagagaatg gagaagatac aatcatcaaa
     5461 gaataaagga tataaatctt taagtttgag ttatagtgta aaaaataatt ctaaaaaatt
     5521 tctatcaata gagatgacaa aaaatgagat agaggcttca tcatatgtga gtaaggtaca
     5581 ttatactatt gataaaaaaa gacaaatagt tttgactttg ccaatgcttt ttaaagatga
     5641 taagtatata aaagttataa gtgataatat aaaagaacaa atgagagaac aaatgaaaaa
     5701 ggatagtaca aaatcctatt ttatagatca aaaaaaagac ttgcctgttg aagattttaa
     5761 aacaattaat aagtatcagg atttttattt taataaaaat gaagaccttg taatttgttt
     5821 tgatgaatat gaagtagcac ctggttatat gggcgcagtt gagtttgtaa taccatataa
     5881 agtaataaaa gatttgtaaa ttgaatagta gtttatatat aaatctttta aggaggacaa
     5941 tatgactaca tataaaaaac ttaaaaaatc tatatttaaa attgctatat tttcaatatg
     6001 cttattagct tcattagtag atacaaaccc tatatttgca ggtagttcct ttaatgaaac
     6061 ttcaaatagt gatacgataa aggtgttaaa tgctaagagt atcaacttta aacaagacaa
     6121 ttatgaagtg aatgtgagta ttcctaaaat aaaaggttta aaagataaaa ctttagagaa
     6181 taaattaaac aatgagtttt tgcaagatgg gaaaaaaatt tacagtgaat ttcaaaataa
     6241 aatgaaaaag gaagataata agggtcatag atacctaaat gtaatccata atgtcaaaaa
     6301 taattctaag gactttttat caatagaaat gacaaaagaa gagatagaag cttcctcatc
     6361 tataactaag aagcattaca ctgttgataa aaatagagga atactattaa atttaccaat
     6421 attttttaaa gatagtagat atattagagc tataagtgat aatataaaag agcagatgag
     6481 aaatcaaatt aagaaagatg atacaaaatc ttattttata gaccaagata aagactcgcc
     6541 agtgaaagat tttgaatcta taaataagta tcaagatttt tattttaata aaaatggaaa
     6601 tcttgtgatt agttttgatg aatatgaagt agctcctggt tatatgggag cagtagaatt
     6661 tgtgatacca aataaagtaa taaaaagact aagatagata tatagaagat ttttagatag
     6721 actggtaagg agaattatat gaatatatat gaacaagcaa taagattaat agaaaataat
     6781 gaggatttcg catttgctac aataacgtct cattcaggtt caacaccacg tgaaactgga
     6841 gcaatgatga ttgtgaaaaa tgattctact atatttggct cagtaggagg aggtagtgta
     6901 gaagcagaat gtataaaaca tgcaattaat gttataaaaa acagagaatc aatgttgtat
     6961 aaatttactc taaacaaatc tgatgttgca aaactaggaa tgatatgtgg aggtactgga
     7021 gaaatacaaa tagattttat agatagtaaa ttaaaaagta atatagaaaa atttaataag
     7081 agactaaagg aaaatacaag taaagcatat atatttggtg caggtcatat ttcaagagat
     7141 gttgctgtga tactatctct tttagaattt agaacagtag taatagatga tagagaagaa
     7201 tttgctaatc atgaaaggtt tccagaatca gaagtagtag ttttagattc ttttgaaaac
     7261 ataccagatt ttccaactga cgaaaatagt tatataatta ttttaacaag aggtcatcta
     7321 tatgattcaa gtgctttaga atgggctctt aaaagagagg ctggttatat aggtatgatt
     7381 ggaagtagaa caaaaattgg attgacttac gaaaaactca tgaaaaaagg ttttaagaag
     7441 gaagaattat caaaagtaca tgcaccaata ggcataaaat tgaatgctca aacaccagct
     7501 gaaatagctg tatgtatagc tgctgaactt ataaattgta gagctaataa ggaaaaataa
     7561 actaatgaac acagggagta aagatattga tactttaaag gttaatttta gagggattga
     7621 aataaaagca gttttagtat ataaaaatag aaaaaatatt tctataaaaa tagatccatt
     7681 tggcaaaata actgtaatga gtcctcctaa aatatccaaa aaaataataa aagatataat
     7741 tattgaaaaa ggagactgga tacttaaaaa gtcagaaaaa tgtaaaggaa gagaggaagt
     7801 atataaacaa agaatgttta taactggcga aaaatttctt tatttaggtg aagagtacca
     7861 tttagttata aaagaactgt tgagagattc tgtcaaaaaa agtaactgta gaataactat
     7921 taacgaatat caaatagttg ttcagacaaa tgatacaagt acagatttta ttaaaaaatc
     7981 tttaaaatct tggtataaga tggaaagtga aagaatagta ttagagagaa tagattttct
     8041 taaattaaat tgtgaaataa tgaagcaatt agttccagcg agtgttaagg taaaagaaca
     8101 aaataagaga tggggaagtt gtacagctca aaaaaatatt tatataaact caaaaatatc
     8161 tatggcaaga ttagatgtaa ttgattatgt aataatacat gagtttagcc atttagtaca
     8221 tatgaatcac tctaaaaaat tctatgattt agtaaaatcc attatgcccg attataaaga
     8281 taaagaaaat tggctaaaaa taaatggata taaaataata atctgaaaac gattattcca
     8341 aaatataggc gtaaagtata aaagaagtat tattgtgaaa aaaataaata atctgaaaat
     8401 tttaaaaaaa gtcattgaca ttgtaaatga tagggaatat aatctatatt aacaacaaaa
     8461 cagaattaaa atataaaatt aaaaaattaa aagcaatgac agagacaaca atactaatag
     8521 tgttatccac agagaaccaa tgttgctgag aattggtgtt aacagtagta taatgatcac
     8581 tctggagctt ttgtactgaa tatttttagt aagtacaaac gtatgtcagc gttacatgac
     8641 taaggttaag gtaattaatt acccgacctg aaaaaagagg ggtagatgta ttttttatat
     8701 ctacaaataa ggtggtaccg cggaatataa ctttcgtcct tataagtaat atttatattg
     8761 cttataaaga tgaaagtttt tttattttaa gcgatataaa taaatttaat ccatataaaa
     8821 ttaataaaaa aataataaaa ataaggaggg atttttatgg aaaatactgt atatgctaaa
     8881 ttaaaccaag gaatagattc ttttttaaga gtggctatga ctctaagaag aagagaggtt
     8941 gatatacaat caataagtat gactgtagat aatatgaata attcaggtat aaaattaata
     9001 gtaaatgaag aaaagacatc cttagattct gtcttaaacc atatgaaaaa actacatgat
     9061 ataagagaga taactgttga aagaatgaga cattaattaa atatatttta taaagctaaa
     9121 gataaatatg cttattttaa aataaaaaac taaagataaa tattaaataa gaaaaatctt
     9181 agattaaaat ataagtgtca ttgaatttat tagtttatca cagttaataa atttattagt
     9241 ttgttgtagc taataaaaac tgaaaattct aaaattataa ttgtaagatt atataaattt
     9301 agaatttaaa tctgttgaat aatattaaaa caatgataat gagtatgaat ttctaataaa
     9361 aataaatatc ataaaaataa gaaaaagtat tgggaggaaa tgaaaatggc aagaatgtat
     9421 tatgaaaaag atgtggattt agaagtttta aaaaataaaa aggttgcagt tttaggttat
     9481 ggaagtcaag gacatgcaca tgcacaaaat cttagagata acggtgtaca tgtagtgata
     9541 ggtctttatg acggaagtaa atcagcacaa aaagcaaaag aagatggatt tgaagttaag
     9601 agtgtagcag aagctacaaa agaaagtgat ttgacaatga tgttaatgcc tgatgaaaaa
     9661 caaaagaaag tttatgaaga gagtgtaaag gataacttaa aagaaggcca gacattagct
     9721 tttgctcatg gattcaatat acattataat caagtacaac caccagaatt tgttgatgtt
     9781 gtaatggtag ctcctaaagg acctggtcac ttagttagaa atgtatttac aaagggaagt
     9841 ggagttcctg cactatttgc agtatatcaa gactacacta aaaaagctac agagacagtt
     9901 ttagcatatg caaaagggat aggagcaaca agagcaggtg ttttagaaac tacttttaaa
     9961 gaagaaacag aaacagattt atttggagaa caatcagtac tttgtggtgg aataagtgaa
    10021 cttataaaat tgggatataa aacgcttgta gatgcaggtt atcaaaaaga agtagcatat
    10081 tttgaatgtt tacatgaaat gaaactaata gtcgacctta tatatgaagg tggatttgaa
    10141 agaatgagat atagtataag tgacacagca gaatatggag attatgtatc tggtaaaagg
    10201 gtaataactg atgttgcaaa acaaggtatg caaaatgttt tagaggatat acaaaatgga
    10261 aaatttgcaa aagcgtggat taaagaaaat gaagaaggac gtgaaaactt cctaaaaact
    10321 agagaagaag aatataatac agaaattgcc gaagttggta gaaatctaag aagtatgatg
    10381 tcattcttaa aataaatata tattaaatgg attagtttga gggaaagagt ggtgtatagt
    10441 agtgcgtatg aatggagcaa aggtaatttt agaatgttta aagaaagagg gaattgacac
    10501 aatatttgga tatcctggtg gagccgtgat acctctttat gatgctctat acgattattc
    10561 agatgatttt aaacatataa ggacatccca tgaacaaggt ttagttcatg ctgcagatgg
    10621 gtacgcaaga agtactaata cagtaggagt ttgttttaca acatctggtc caggagcaac
    10681 aaatgccata actggaatag caacagcttt tatggattct tcacctatgg ttgtaatttc
    10741 agggcaggtg ccaactagtt tattaggaaa agattctttt caagaaattg acataactgg
    10801 agcaacatta tctatgacaa aacataatta tttagttaga aacactaaag aattagttcc
    10861 tacaataaaa gaagctttta gagttgcaaa ttcaggtaga aaaggacctg tacttgtaga
    10921 tgttccaaaa gatttatttt tagcagaaat ggattttagt ggtgaggact atgatttatg
    10981 tcaaatagat gattatatgg attataagag tgattttgat ctagatgatg aaactaatat
    11041 taagctttta aatgaagcaa tagatatcat aaaagaatct aaaaagccta taatatatgc
    11101 aggtggaggt gttaaatctt cagacagtga ggaaattctt gaaaaatttg caactaagat
    11161 agatacaccc gtactaaata cacttatggg gcttggaaat atagatagaa agaatgaatt
    11221 atctcttgga atggttggaa tgcatggaag tagagaaagt aatttagcac tttctaattc
    11281 agatttagta atagcgatag gtgcgagatt tagtgataga gtgataagta aaagttctga
    11341 atttgctaaa aatgcaaaaa taatacacat agacatagac ccatctgaaa taagtaaaaa
    11401 tatagaatct aatgtatctt tggttggaga tgtaaagcta gtccttagtt tattaattga
    11461 aagggttgaa agtaagaata atagcaattg gaaagaagag ataaagagat ttagaaagag
    11521 tgagggtgta caaacatatg aatttcatcc acaaaatata cttaaaaaaa taaatgaaaa
    11581 atatgaaaca ttaaagaaac ccactgtggt agtaactgat gtcggtcaac atcaaatgtg
    11641 ggctgctaag tactggaatt ttaaaggtaa taaaagtttt ataacatcag cagggttagg
    11701 aactatggga tttggtttag gtgcagctat tggaactaaa gttggtaatg tagataaaaa
    11761 tgtggtttta gtcactggtg atggaagttt tagaatgaac tgtaatgaac tagctacagt
    11821 tgcaaattat aatgtaccta tgcttatttt actactcaat aatagaacat taggaatggt
    11881 aaggcaatgg caaaagttat tttccaatca aagatactct caaactgaca ttaatgaaaa
    11941 tgtggattat gttaaactcg taaatgcata taacattgat ggatataagg tatccagtat
    12001 ggaagaatta ggaaaggcgc tagatatgat agattttaat aaacctgtat ttttgcaatg
    12061 tgatatagat aaggattatg atgtttatcc tattgtagca cctaatgatg cattggaaaa
    12121 tttgatatgt aactaaaact tatactgaat attgataaaa ttttttatta aatttttatt
    12181 agtattcagt ttttgttgtt tagagataga ttggcatttt ttatttttgc aaataaatca
    12241 atgactatat aattaagaac ttattaaatt ttaattatac aatttagaat agtattacaa
    12301 cttaagtaaa taataatttt gaataataat ttacggaggt attcatatgt ttaaacacga
    12361 taaagcatta ttaaaagaag taaaagtaga aagaccaaat cctcaatatg ctgttttaat
    12421 gcaagaacag ttgggtggtg caaatggaga gttaaaagca gctatgcaat acttgtccca
    12481 aagttttaga ataaaagacc ctcaaataaa agatttattt cttgatatag cagcagaaga
    12541 gcttagccat atggaaatgg tagcacaaac tataaattta ttaaatggac atgatgttga
    12601 ttataatgca gttaatacag gcgaaataga aacacatgta ttaactggtc tatcaccagt
    12661 cttaataaac tcatcaggag ctccttggac tgctaattac gttacagtta caggggattt
    12721 agtagctgac ttactttcaa atatagcttc tgaacaaaga gctaaggtag tttatgagta
    12781 cttgtataga caaatagatg ataaatatgt aaaagaaaca atagatttct tacttaatag
    12841 agaagaagca cataatgctc tatttagaga tgctttaaat aaagttaaag atacaggttc
    12901 aaatagagat tttggagtta cagaagattc taaattatat ttcgatttgt ctactccagg
    12961 gccaaatcac gatactaaga tagatattaa tcctccttct tttgaaaaac ctttaaaaaa
    13021 ataatttgat attttttatt ttgttttagt agttataaaa attatttact agaagaatta
    13081 attatatgaa aaattaaata tgtatagtta aaaatgggta tacacttatt ataagtgtat
    13141 atctatttgt ttattgcaaa acatataata aaataacaaa tgaggtggta ttttggacag
    13201 taatagaaaa cctaataatc taataaatga aaaatctcca tatcttttac agcatgctta
    13261 taatcctata aactggtata gttggaatga tgaggctttt aaaaaagcaa aagaagagga
    13321 taaaccaata tttttaagtg taggatattc aacatgtcat tggtgccatg ttatggaaaa
    13381 agaatctttt gaagatgaag aagttgctga aataatgaat agaaactttg tggcaataaa
    13441 agtagataaa gaggaaagac ctgatgtaga tagtgtgtat atgacagttt gccaagctat
    13501 gacaggtagt ggtggatggc caatgaccat aataatgaca ccagataaaa aacctttttt
    13561 tgcgggaaca tatttcccaa aatattcaag gtataataga cctggagtta tagatttatt
    13621 agagaatgta tctgaaaagt ggaatacaag cagagatata ttaataaaat ctggagatga
    13681 aataatagaa gctcttaagg atgattttgg tgtaaaaaat actgagggtg atttatcaaa
    13741 agagatgttg agttcatcag ttagagtatt taaggctatt tatgatgaaa agtatggtgg
    13801 ttttggtaat gctcctaaat ttccaagtcc tcagaatctt atgtttttaa tgaaatatta
    13861 tagtatagaa aaagacaaag atgtgttaaa aatggtggaa aaaactttag atggaatgta
    13921 tagaggaggc ttgtttgatc atattggatt tgggttttca agatactcta ctgataaaaa
    13981 gtggttggct cctcattttg aaaaaatgct atatgataat gctatgctta ctatagcttt
    14041 tttagatgcg tataaaataa caaagaaaga gttgtataaa gaaattgcta taaaaactat
    14101 agattatgta gttagagaga tgaaggataa agaaggtggg ttttattcag cacaggatgc
    14161 tgatagtgaa ggtgaagaag gtaaatttta tacatttaat cctcttgaga taattgaagt
    14221 tttgggtgaa gaagatggaa ttttctttaa taattatttt gatataacta gtagtggaaa
    14281 ttttgaaggc aaaagtattc ctaatcttat aaaaaataaa gaatatgaga gacataatga
    14341 aaagatagct gaccttagta aaaaggtatt tgaatataga aaagaaagaa catctttgca
    14401 taaagatgac aagatactta catcatggaa tgcattgatg atagttgctt taacaaaggc
    14461 atatagtact ttaaaaaatg acatatattt agagtattca aataagtgtc ttaactttat
    14521 aaataataat cttgtaaatg agtcaggtag attattagct agatatagag atggaagttc
    14581 cgactattta gcatatttag atgattatgc ttttttaatc tgggcgtata tagagcttta
    14641 tgagtcaaca tttaatatga aatatttaga aaaggcttta aatttgaatg aaagctgtat
    14701 caaccttttt tgggattatg aaaaaagtgg attttatata tatggtaaag atagtgaaaa
    14761 tttaatagca aggccaaaag atttgtatga tggagctatt ccatcaggaa attctgttca
    14821 attatacaat cttataagac ttgcgaaaat tactggagat aatagacttg aagaaatgtc
    14881 atataaacaa ttaaaactgt atgtggataa tgtaaagagt tctccagctg gctacagctt
    14941 ttatatgctt tcattgatgt ttgaacttta ttctactaag gaaattatat gtatttttaa
    15001 ggaagattct gatttaattg cctttaaaga attgataagt gaaaatttta taccaaatgc
    15061 aactttttta gcaaagaaat acaatgaaga aaacactatt ataggttttt taaataacta
    15121 tagattgaag gatgataaga ttagttatta cgtgtgtcaa agtaatagtt gtagtcaacc
    15181 aattaatgat ttacaaaaat taaaagatat gattttagga gtagaataat cataatagtg
    15241 aaaaaggaga tgctttaaaa taaaagtcta atcatctcct ttttttgtac aaaaaacaga
    15301 aaaagagttc ctgagaacac ctaatctatg taatgattgt tttgttaaaa aataaaaatg
    15361 acattatagt tatataaaat attgtactat aaaaaagtag tattatagat gcgatagtat
    15421 taatcgtttt tatttactct ctttcttctt tttgcaaatt cttcaagtgc ttcagattta
    15481 attttatcta tttcttcata ttccataaaa ttagcatctt cttcaaagcc atcttgttct
    15541 tcaccattaa aacgatacat tttttttagt aaactccata aggtctctaa ttcatctttg
    15601 gtaaattcgt gaaatacatc tgccataaag tttattccag tcctactaca tgttaccata
    15661 accttttttc ctaagtctgt aactttaaca ttaattgctc tcttatcatg aggacttgga
    15721 attacatcaa catatccatt tttttcaaga ttagcaacta gtctatttat attttgttta
    15781 cttgtaccca tttttcttgc aatattattt aatgttgttt cttcctctgg taaatgaaga
    15841 attgataaaa tagtcatata ctgtcttgaa gtaagtatac caaaatattt atctccttct
    15901 atttgtattt tgtttgtaag ggtaaaaaga gttgcatatg tttgattcat taaaaagagt
    15961 tcttttagtt catttgaata atccatgaaa tatatctcct ttatttttag atgttgtttt
    16021 gtcgaaaaca gaatatcatg aattaattct aatgtcaata tggtgtcaaa atatattaaa
    16081 gtattacttt tttatgtaac tattaattaa ttaaattatt gtataatttt atgtaaaaac
    16141 ttctatgtac caatgataac ttctatgagg aattaataat tcttaaattt tttagaaaga
    16201 ttttgacttg aaaatacttg taatataata tataaattaa tatactgaat aaaatcaatc
    16261 tggagggata attatgaagt gtacaaactt tactttcaaa ggagaggaag gtttagatat
    16321 atatacatat aaatgggaag atgaaaatat aaaaaaacca aaggcagtta tccaaattgc
    16381 acatggaatg gctgaaactg cacaaaggta tgagactttt gccaaggtac ttactaaaaa
    16441 tggttatata gtatatatca atgaccatag aggtcatggg aaaactgcaa agataataga
    16501 aaatgttgga catttagctg aaaaagaagg atttagatgt cttgtagagg acatgtatac
    16561 tttaacaaat attataaaga aagaaaatga agatctgcca atttatctat ttggacacag
    16621 catgggttca tttgcaagtc aaagatatat aatggattac agtaataatt tatctggtct
    16681 tatactatgt ggttcaaatg gaaagcaagg aatcattcta aatcttgctc atctgataat
    16741 caatcgtgag attaaaaagt atggaagacg ttctaaaagt aataaaataa ataatttgat
    16801 atttggcggc gaaataataa gaagaaatga aaagactaag tttgactggt taagtagaga
    16861 taaagaacaa gttgaaaaat atataaatga cccattttgt ggagtagtgt gtagttgtgg
    16921 ctttttttat gatttagttc aagggttaaa agaaattgag gataaagaaa acttaaaaaa
    16981 agtgccactt gatataccta tttacataat atctggagat aaagacccca taggaaaaaa
    17041 tggtaaagga gtcttaagac taagggatag atatataaaa ttaggagtaa aagatgtaac
    17101 ttgcaaactt tacaaagatg gaaggcatga attgttgaat gaaataaata gagaagaagt
    17161 ttttgaggat ataatttgtt ggttaaataa taaaatagaa atattgtaat aaaaaaatat
    17221 aatgatatat ttactttaaa tttatttata tataatattt gaaaagtgga ttatgtatat
    17281 gcaaagtaga aaagagagag cccagaagtg attttttgct ataatgccat ttattgaata
    17341 ggtgggtgtt attataaata aattattaac actcagtatt attatcattg tatatggaat
    17401 ttattttatt taaaattcct tgaaagttta aatatagtaa gttgtagtaa agagaaaata
    17461 taaatattta aatgctattt aatgtgaatc tattaattag gttatactta aacttaatta
    17521 atagatttta tatttcaaga caatgagata gggttttaga ttaaaatata accaatggtt
    17581 aaattacaga cattttgtta actttccctc gatttactag taaatatttt ttttatatac
    17641 ttaaattaca acagatgtac tagggaggta tatatgcaaa ttaaaatagg taaagtcata
    17701 cagtgtctta gaaaagaacg aaatttaact caagaacaat tagcaaagtt tataggtgtg
    17761 tcaacaccag cagtatctaa gtgggagagt ggaaattctt acccagatat agaattattg
    17821 cctttattag cagacttttt taatgtgtct attgataagc ttttaaatta caagattgat
    17881 ttaagtgaag aagaagtaat gaaaatttat aaagaattag aatcaggctt tgctagaatt
    17941 gaaattgatt tatcaacaga agaaccaaaa gaagaattta gacaagattt agaatctgta
    18001 aaaaagcttt ccaatatgta tatagagaag tatcctaaaa gctatttatt gaagctaagg
    18061 atatgttcgc tgtatcagat gtattcatat aaatttggta agagtgaact taatgacaga
    18121 gtaaaagaaa caacgaatat tcttgaagat atagtgagaa atacagatga tatccaaata
    18181 aaagaaacag ctcttattat attatcaaac gcatattgta tgttggagga ttatgaaaag
    18241 gcagagttgt atttaaatat gatacataag tcaatagggg atacaagtgt taatttagct
    18301 atgatatatt taaagcaaaa tagacttgaa gaagcagaaa tattgcttca aaataaattg
    18361 tttagtaatg tatttaatat aagcatggat tgtaagggaa taattaatgt atacaaaaat
    18421 caatacaagg aattaaagaa aaaattggag aatagaaatt ttaataaaaa tgcaattgag
    18481 agagaaatgg agtatataaa aaataagttg ctggggtatg caaatctttc tttagaaata
    18541 aaaaaaatgc tcagtgaaga taaaggtgca ttttttagta tgtatatgga ttatatggaa
    18601 ttatctctaa tttttttatt ttttaacatg aaagaagaag caaaaaaagc tttatatagt
    18661 ctaaaagaaa tattagaaaa atatcctata catgaaagtt tggatgtaag tcaaatgaga
    18721 ttttttgata aggtagagtc taaaaattta tatactttta atatatatac aaacttgtta
    18781 attgtactta atgatgacag ttataatgag cttagagaag aaccaatttt taaggatgta
    18841 attgaaaaga ttttagatat ggaaaaaatg ttgaaaaata aagaataagt aaaaatttaa
    18901 tataggactt aaagattaat caaattaaaa gaaagtgttt caaaataaaa atttgaatca
    18961 ccttttttgt cggtcttaaa cagttattta gaaaaataga ggtttcaaaa tagaaatctg
    19021 aattatctgt attattacac aaaaatagaa acctaaattt ataaaaatag aataaaattt
    19081 gttatataaa atgtaatttt gtctataaaa tctcacctgt tttcttaact ttaagcgtga
    19141 aaaagaggat gtatcatgaa ttttttagtt catgatgcat cctgctttgt atgaaatcca
    19201 atatatcttt attatttaaa caatggaaaa gagtcttatt tatattttga gacatctctt
    19261 ttatttaatt atgaagtttt atacagttca ataaatagga attatattta gaaactcatg
    19321 acattatttc ttagatagtg attaaattta tcatattcca ttttagataa cttttctggg
    19381 taagacatta caatcaggtt atgcccatta aattttttat ggtatggtgg atgaatgtgt
    19441 tcataattat ttgtcttata ttttactctt tcatagaacg ccttgcgata aattgaaatc
    19501 tcatcaattg gaaggtcaat ttctaaaata atagtttttc ctttcttatt taaaagctct
    19561 aacgctcttt gcccatatct attattgcga atttctggaa aaatgcagaa atgttctaca
    19621 tagataaagt tatctgtttc ccaacataaa attatgccga caaactggtt tttatcataa
    19681 attaaattga attgatattc tttatttttc aaaatttctg cttgcaaaga agattttctt
    19741 tgtttatgaa atgggaaact aattttatat aattccatag ccttgtaata taatttattt
    19801 tcactggttc ttaaccgttc aaatttcact ttactcctcc taatcacgaa aattccaatt
    19861 tatttatgag ttcattttac catagtcagt atttgcatac aatgtgtttt aagttgagtg
    19921 tcatttcttt cttttattta tgcttatatc tcatagtcta agagataatt gcttaagaca
    19981 taactaaaaa ctattatatt aagctttgat aatctaaaaa cagtatattt atggactttt
    20041 ctaggtctaa aagtaatctt aataatttta gaagttacaa aaaagttaca taaatttgga
    20101 aagctataat atacatatat aatataaggt taaaactgta atgaataata ttaatttaaa
    20161 atttgaacat ggaaggagat tattatggag aaaagagaaa agaggataat aatatcatct
    20221 ttattaagtg tatcaatttt aatgggtttg gcaagtatat attctatatt aaataaagaa
    20281 gacataagtt taaccgttaa aggtcaagag caaaaagtat cttcctttaa gaaaacagtt
    20341 gaggaacttt tggatgaaca gggtgtaaag tataattctg aagataagat taatccaagt
    20401 ttagatacag agttaaaaga tgatatgaaa ataaaagttg ttaaggtaac taaaagtaaa
    20461 aaagaagaga ttgaaaaaat tccatttgat acaaagcatg taaatgatag taatttgtta
    20521 aaaggaaaat ctaaagttta tcaagaaggt caagaaggag aaaaaaaact agtctataat
    20581 ttaacttacc atgatggcaa gttagtcaaa aaagtcttat caaaagaagt aatatctaag
    20641 gagccaacta caaaaattat aaaatatgga actaaagaaa aagtactaat agcatcaaga
    20701 ggagcaaata taagaggagg caaacatatg aaagtggttg ccactgcata tgcaggagat
    20761 acaataacat ctactggtac aactccaaga tggggtgtta ttgcagttga cccacgtgta
    20821 ataccatatg gaacaaaagt atatatacct aaactgggta tgacttttgt agcagaagat
    20881 tgtggaggtg caattaaagg taatagaata gacattttta tgaacagtga aggaaaagct
    20941 tcaaattggg gaaggaaaag tatagatata tatctacatt aaattagtga atagaataac
    21001 tttacttgaa ggacaaaaaa gtataaaata tgaattaact aaactgttag attattctta
    21061 aaacataaaa atatatctaa ggggggataa gatgaaaata gtctgcttag gagacagttt
    21121 aacgtatgga tttggagtat cacgaagtaa ttcatggaca aacattgtaa ataaagagac
    21181 tcgattagaa atagtaaata agggtataaa tggtgataca acaagtggta tgttagctag
    21241 gtttaatgaa gatgttgtaa aaaactctcc tgatatagtt tttataatgg gtggcaccaa
    21301 tgattttatt gctggtgcgg gaaatgaaat tattaattct aatataatgg ctatggtgca
    21361 tcagtcatat tcaaaaaata ttatacctat aataggtata ccattaaaac cagatattcc
    21421 aaatgttagg gaagattgga gttgttttac tgattttaat atagtatctc aaaacttaga
    21481 atcatatagt tattggataa aaaaattttg tatgacattt aatactaatt tcgtagattt
    21541 ttattcagaa tataataaaa atatggaact agaaggatat aaaaaattat attttgatgg
    21601 gttacatcca accaaagagg gtcatagaat aatggcagac atttttatta attcaattaa
    21661 taagtatata gaagagttat agattacatt aaaatgcttg tttatgcgtc agttgcaata
    21721 aatacataca gtagagaggg gtttattatg gattatacta aaacttatga agagtggata
    21781 aagggttcat attttgatga agatacaaag ctagagttgg agaatataaa aaataatgaa
    21841 aaagaaatag aggatagatt ctataaggat ttagaatttg ggactgcggg tcttagagga
    21901 ataattgaag caggaacgaa tagaataaat aagtacacag ttagaagagc tacttttgga
    21961 ttggcaaact atatattaga aaacacaaca aaagaagaaa caagtagagg agtagtaata
    22021 gctcatgata atagacacaa gtctagacaa ttctgtatag aatctgcaaa tactttggca
    22081 gcatgtggta taaaagcata tatatttgat agtttgagaa ctactccaga attatctttt
    22141 gctgttagaa gcttaaatgc aatcgctggt atagtcataa cagcaagcca taatcctcca
    22201 gaatataatg gatataaggt atactgggaa gatggagcac aagttatgcc agagattgca
    22261 aatgcaataa cagagaaagt aaatagtata catgattata gtacaatacc aaccttaacg
    22321 gaagctaata aaaatttggt agttttgttg gacgaatcac aagatactaa atttatagaa
    22381 gcagtaaaaa gccaaattat aagaaaagat ttagttaaaa atgtaggtaa aagctttaag
    22441 atagtttata cacctctttg tggaacaggg aatgttccaa taagaagagc attgaaagaa
    22501 gttggttttg aaaatataat tgtagttcca gaagaagaaa atccagaccc aaattttgca
    22561 gggcttgatt atccaaatcc agaagagaaa aaagctttaa atagaggtat attactcgca
    22621 aaagaaaaag gagcagacct tgtaatagca actgacccag attgtgatag agtaggtgta
    22681 gcagtaaaaa ctactacagg tgagtatgct ttacttacag gaaatcaaat tggtggtatg
    22741 ctgacacatt atataataga aggattaaaa gaaaataata aattaaaaga aaatcctaca
    22801 ataataaaaa ccatagttac atcagaattt ggagcagata tagctaaagc aaataatgtt
    22861 gatgtattaa atgttcttac aggttttaaa tttattggtg aaaaaataaa attatttgaa
    22921 caaaataaaa atagaagtta tgtatttgga tatgaagaaa gttatggtta cttagttggg
    22981 actcatgcta gagataaaga tggtgtagtt tcttcattgt taatatctga aatggcagca
    23041 ttttactatt caaaaggtat gagtttatat gatggcttaa tagaacttta taaaaagtat
    23101 ggatttttca aagaacagac tatatctttg actttaaaag gtatagaagg tgtagaaaag
    23161 ataaaagaaa taatatctta ttttagagaa aatcaaattg attatataaa tagtattaaa
    23221 gtagttgata aaaaagatta taaaaatggt atagataatc ttcctaaatc tgatgtttta
    23281 aaatactttt tggaagatga atcttgggta gctataagac catctggaac agaaccaaaa
    23341 cttaaatttt acatagctgt aaaaggagct agtgatattg aagcagataa aaagattcaa
    23401 ggtttgaaaa agtatataga tgacatggtc gaaaaattaa aataaaatat tattatttta
    23461 taagataatt ttgtaataat atttatttag ctgaaaatta taatttactt tcattgagta
    23521 gaatatggaa atgttagtag aattgttatt ttcagctttt atttgtgtta tttttactta
    23581 aataattata ttatagaatg aatctgagta taattaatat tgtataatga aattaatttg
    23641 atagaaaagg ggatatttat gtttggtata gataagaaat tgattgaata tataattgca
    23701 aaatccaatt acagtgaatt aagttcaaag tcagcagaag tatctttctt cttaatgttg
    23761 tccatatttc cttttttaat atttacaata agttctatag cttatatacc gattcttcat
    23821 ttaaataagt atatagcttt gtttagaaat atgatgccag aaggtgcttt tgctgtgtta
    23881 tcttcaatca tagtttctgc aatagacaat agaaacctga aatttttagc agtcagtttt
    23941 gtacttacta tgtggacatt ttcaagagca gtaaaagctc ttattaaagg aatgaataga
    24001 gcctataaag ttaaagaaac taggtctttt tttaaaattt tatctatatc atttttattt
    24061 acaataatgc ttttggtcct tattttttta tctatgatat ttttagttta tggggaaaaa
    24121 ataggttatt ttatttttaa tcttgtagga ttggatgaga tatttataaa aatatgggat
    24181 attctaagat acactgtagg tataataaca ataatagtga tatttacact tttatataaa
    24241 tacactccaa ataaaaagtt aactattaaa gaatctgcgc caggtgctat ttttgctact
    24301 tttgcttggt ttttagtatc atttttatat tcttattata caaattacta tgctaactat
    24361 gaagtaatct atggaagtat agctgaaata attgtactta tgacctggat gtattttagt
    24421 agttggtcta tcgttattgg ctatgaggta aattcaagat tgtattttag aaagataaga
    24481 catgaaatgt taaagtaaag tatttaaaat aaaagagagt atttagtatt ataaatgtaa
    24541 ttgaattaat aaagaaatat tgacatttaa gttaaaaagt ctagaatttt tctgggcttt
    24601 ttttattttt agtataactt gacaaatttt at
//
LOCUS       DAEHWM010000058        24477 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.059, whole genome shotgun sequence.
ACCESSION   DAEHWM010000058 DAEHWM010000000
VERSION     DAEHWM010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24477)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24477)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24477
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.059"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            39..155
                     /gene="rrf"
                     /locus_tag="KNP36_002349"
     rRNA            39..155
                     /gene="rrf"
                     /locus_tag="KNP36_002349"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            275..466
                     /locus_tag="KNP36_002350"
     CDS             275..466
                     /locus_tag="KNP36_002350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF378 domain-containing protein"
                     /protein_id="HBF0874215.1"
                     /translation="MKKVALILAIIGALNWGAIGILGTDLIGSIFGGTYEMVSRIIYF
                     IVGLAGLYLIPSLMSDDRE"
     gene            621..2030
                     /locus_tag="KNP36_002351"
     CDS             621..2030
                     /locus_tag="KNP36_002351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBF0874216.1"
                     /translation="MFIINELNKIVNEEVISFHMPGHKKGQVYKKLGYKDILKNLYKM
                     DTTEILGTDNLHFPEGIIKNSQKKASRVFKSDYTCYLVNGSSCGIQSAIMSVCSPKSK
                     IITNRDCHQSVINGCILGDIDIEYVPCEISEETNVLKGISISNVIDIIDKNLDAKAVL
                     LTYPTYYGMTYDLEYICNYAHSKKMVVIVDEAHGAHLGLSERLPKTALEQGADIVVQS
                     THKTLPAFTQSSMIHIQGDRVDIDKILNMLRITESSSPSYLLLSSLELAVDIYENKGK
                     ELMEELLNNIITFKNKVDSNINIYDTNDKTKIFISSKNMGLTGYELENILRNKYNIQV
                     ELSNYYGVLLICTIGNTVEDFSSLETALNNIVKEDFKFEKLENKKYPVVIPKKILTPR
                     EAFYKTKKSVKIYDSIGKVCGECIVPYPPGISVISPGEVISKEIIDYLMFCHSKGMIV
                     SGLKDVDLNFIQIIDLEDI"
     gene            2161..2850
                     /locus_tag="KNP36_002352"
     CDS             2161..2850
                     /locus_tag="KNP36_002352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate kinase"
                     /protein_id="HBF0874217.1"
                     /translation="MKGKLIIIESGSDASGKATQTEILYERLKKEGYMIKKVEYPNYE
                     SPSSALVKMYLKGDFGKNASDVDPYIASTFFTADRYASFKTDWEEFYNEGGIIIADRY
                     TTSNMVHQASKMDICDREEYLNWLADYEFNLFKIPQPDCVIFLDVPIEFSKKLMENRK
                     NKITGEEKKDIHESDIEYLEKSYNNALYIADKYDWKKINCVLDNKLRSIESIHNEIYK
                     IVLDSIKPMER"
     gene            2853..3788
                     /locus_tag="KNP36_002353"
     CDS             2853..3788
                     /locus_tag="KNP36_002353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HBF0874218.1"
                     /translation="MYFENIIGQDFAKKYLTNSIKKNKLNNAYMFEGMDGIGKKKFAD
                     ELSKLLLDYENLENSPDYVLIKPDGNSIKIAQIRNLQSDIVIRPHKDYKIYIINNAEK
                     MTVEAQNALLKTLEEPPNYAIIILVTNNKESLLETIKSRCDIIKFSPIPIEDLKRYLI
                     NTGIEEERAQLLAIFSRGSIENALNLSQSSEFSMMREDIQQYIQIMLDKNIVEILNIP
                     NNMEKYRGKIIALLDMMINYFRDIILLKENVNKNMLINVDKLVFIQNMSGKISYSQLS
                     KIIDIIEDAKSKIKSNCNFNISIQVMSLNIYEVIK"
     gene            3785..4678
                     /locus_tag="KNP36_002354"
     CDS             3785..4678
                     /locus_tag="KNP36_002354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="stage 0 sporulation family protein"
                     /protein_id="HBF0874219.1"
                     /translation="MIKIVGIRFKSAGKIYYFDPVDFNIEQDMDVVVETARGLEYGKV
                     VVGPKDMDESELVSPLKPIIRIATEEDKKVYLENKEKAKETFELCQQKIKEHELTMFL
                     IDCEYTFDRNKLIFYFTAEGRIDFRELVKDLAAIFKTRIELRQIGVRDEAKSIGGLGP
                     CGRKLCCSSWLGDFQPVSIKMAKDQSLSLNPTKISGICGRLFCCLKYEHDVYSEAIEK
                     MPVVGALVQSDDGKGKVVEVNPLLEQIKVEFQDKTVKIYTREDIKILREPKKCDGCGG
                     KCKDNDGLDEATLRELKKLED"
     gene            4756..5502
                     /locus_tag="KNP36_002355"
     CDS             4756..5502
                     /locus_tag="KNP36_002355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HBF0874220.1"
                     /translation="MQLKDSERIDDLQLKGLKIIQDTNGFCFGIDAVLLANFTKIKKD
                     AKVVDLGTGTGIIPILIAGKSEAKKIIGVEIQEDVYEMATRSIKLNGLEERVEIINED
                     IKYIDKVLDINGYHVVTSNPPYMHIDGIKNPNDKKAISRHEVRCNLEDVIRAASRLVM
                     PRGKFFMIHRPTRLVDIITLGRKYKLEPKVIQFVHPRPQKAPNLVLVQFVKDGRPELK
                     ILDPLYVYGEDGNYTKELKAIYNNKDIGEL"
     gene            5503..6336
                     /gene="rsmI"
                     /locus_tag="KNP36_002356"
     CDS             5503..6336
                     /gene="rsmI"
                     /locus_tag="KNP36_002356"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HBF0874221.1"
                     /translation="MSGKLYICPTPIGNLEDITYRTLRTLKEVDLIAAEDTRHSIKLL
                     NHFEISKPLTSYHEHNKDSKGDYLINKLIDGENIALISDAGMPGISDPGEEIIKQAIQ
                     NNIEIEVLPGATAFVTALVGSGMDTHRFVFEGFLDRDKKVRKAQLEELKEESRTIIFY
                     ESPHRLKDTLKDMLKILGNRNISINRELTKKYQEIIRENIETTIKIFEEKEIRGEFVL
                     IVEGFHGEKSKKENYDGLTDREYVLKLIESGMNKKDAIKIVCKDRKLKKDVVYKQVLD
                     L"
     gene            6359..7063
                     /locus_tag="KNP36_002357"
     CDS             6359..7063
                     /locus_tag="KNP36_002357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HDIG domain-containing protein"
                     /protein_id="HBF0874222.1"
                     /translation="MEIGKIIIESLKREDTHKIFIELDNKHELEKIIPKISCMKSVGE
                     CKYHVVNCFEHSINALKELEIVLNDKDFFPIHLRKHVSNYLNTYIEEGINKLHVLKLG
                     TFLHDIGKPDSMTLDETGRVHFTNHEKIGAQIIDNMGIKLELSTETYRLISKYVRYHM
                     ILLSLYKKNDLSRKELINVFNLVDEDTIGVIMLGYADIVSTVKLLGKSGEVSVLKTYM
                     EYILTNYLYKSNYTHV"
     gene            complement(7251..7679)
                     /locus_tag="KNP36_002358"
     CDS             complement(7251..7679)
                     /locus_tag="KNP36_002358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007287587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="HBF0874223.1"
                     /translation="MDVTDYRIIEILQDDGRISMKDLGKIVGLTSPAVSERVKRLEES
                     GVIEGYKAIVNPDSLGRVIKAFIHISLPSNGYTEFIESAAKDPRIVECHHITGDDCLL
                     LKVIVKDMYELENVIDTIKKIGSTKTSVILSTPIQAKSIL"
     gene            complement(7716..9146)
                     /locus_tag="KNP36_002359"
     CDS             complement(7716..9146)
                     /locus_tag="KNP36_002359"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HBF0874224.1"
                     /translation="MRNLTLLTDLYQLTMLNGYFEKNIHEDIVVFDMFFRKNACDGGY
                     TIVCGIDQVVEYIDNLHFSDEDLEYLKNLNLFSDKFLKFLKEFKFTGDIYAVEEGTIM
                     FPNEPLITVKAPLYQAQLIETALLTIVNFQSLIATKASRVCFAAQGDPVFEFGLRRAQ
                     GPDAGIYGARAAVVGGCAGTANVLAGKMFDIPIIGTQAHSWVQKFDNELEAFQAYADV
                     YPDKCLLLVDTYDVLNSGVPNAIKVFKNISEKGYKPMGIRLDSGDLAYLSKEAKKQLD
                     NAGFSDISITASNDLDEYTITSLKAEGATINSWGVGTKLITSFDSPSLGGVYKLAASC
                     EKGVLEPKIKISENPEKINNPGYKKVIRIYNEDNKAEADLIMLHDEVIDESKPLEIFH
                     PTYTWKTKVFTNYKVKELLKPLYIKGRCKYNKKAVLEIKNHVQYELSTIWEQYKRLSK
                     PHIYKVDLSRNLWYLKTQMIDSKKVL"
     gene            9278..9862
                     /locus_tag="KNP36_002360"
     CDS             9278..9862
                     /locus_tag="KNP36_002360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore maturation protein A"
                     /protein_id="HBF0874225.1"
                     /translation="MIIIGKIWFYMVSIGIIGSLISKNMGELNKVILSETSKGIEFAI
                     SLAGIMALWMGIMNIAKESGLIEKIGQKLNPIMRRLFPSIPKGHKAMSYIVMNIALNM
                     LGAGNGATAFGLKAMSELQTLNNKKDTATNDMIMFMVINISSIQIIPFTIIKLRMDMG
                     AQNPSEIIFTTLFATIISTAVAIITCKFFQRRYR"
     gene            9878..10399
                     /locus_tag="KNP36_002361"
     CDS             9878..10399
                     /locus_tag="KNP36_002361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore maturation protein B"
                     /protein_id="HBF0874226.1"
                     /translation="MEIFSNLLIPIIILYIVIYGKYKKIDVYDSFVKGAIDGLKAAWD
                     ILPYIIGIFLAIGIFKTGKGLDMLEWLFTPIANMMSIPKELIGLISVKPLSGSGALGM
                     YSELANRVGIGSLVEKMGATIVGSSETIFYTMAIYYGSLKIKNTRHTLSCAMISHVAG
                     VIAAVFICYVIFV"
     misc_binding    10465..10711
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            10795..12732
                     /gene="metG"
                     /locus_tag="KNP36_002362"
     CDS             10795..12732
                     /gene="metG"
                     /locus_tag="KNP36_002362"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HBF0874227.1"
                     /translation="MSKPSFYVTTPIYYPSGGLHIGHTYSTVAADTIARFKRFCGYDV
                     KFLTGTDEHGEKIQKKAIEQGMSEIEYLDGMIKDIKALWNTMDISYDDFIRTTEKRHT
                     DIIQKIFTKLYEQGDIYKGEYEGRYCTPCESFWTESQLLEGNKCPDCGRETYLVKEES
                     YFFRLSKYEDRLKELFKDDSFCFPAARKNEMVANFLDKGLEDLSVTRTTFDWGIKVPF
                     DEKHVIYVWVDALCNYITALGYMTDNDEEFKKYWPANVQIVGKEIVRFHTIIWPALLM
                     ALGLEVPKQVFGHGWILFADDKMSKSKGNVVYPEPIIERYGIDTLKYFLLREFAFGQD
                     GSYTHRNFVTRINYDLANDLGNLISRTVAMVEKYNNGIIPTAKVSTDFDADLKEQAVS
                     TRENFEAEMDKMQFHEALESVWKLVRRTNKYIDETMPWALAKDETKKDELDTVLYNLC
                     ESIRIIATLINPIMNETANKIYEHIGIKGQDDITTWESTKTFGLIGENVKVFKGEPLF
                     PRLDVEKEIEELTKMFSGKPPVEEKPLEHKEEITIDDLDKIELRVGKIISCEKHPKAN
                     KLLVSQVKIGPETRQIVSGIAEYYKPEDLVGKEVTVVCNLKPVKLRGVESQGMILAAG
                     DDGDPYVLPFTQGAKDGCEVR"
     gene            12762..13532
                     /locus_tag="KNP36_002363"
     CDS             12762..13532
                     /locus_tag="KNP36_002363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HBF0874228.1"
                     /translation="MLFDSHAHLNDESFDEDRDELIGSLKDKGVDLVVNPGADIETSI
                     TAIELAKKYDFIYSAVGVHPHDVSKLDDTAIETLRKLATENEKVVAIGEIGLDYYYDY
                     SPREEQKEWFKKQIELANELKLPIIIHDRDAHGDTFEIIKNTKNPEIGCVLHCYSGNV
                     ELAREYVKMGCYISIPGTVTFKNNKKTREVVREIPLERLFIETDSPYMSPEPHRGKRN
                     NPSQVSFVADKIAQEKGISYEEVCRVTKENAKKFFNIK"
     gene            13870..14301
                     /gene="phnG"
                     /locus_tag="KNP36_002364"
     CDS             13870..14301
                     /gene="phnG"
                     /locus_tag="KNP36_002364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnG"
                     /protein_id="HBF0874229.1"
                     /translation="MYTVDSTKILINMNLEKLEKIYSMIKDTSSISIIKEPNLATVMV
                     RANESVKNTTFNLGEILVTECSVKVDESLGYGIVSENNNKKAIYLAVIDAVLHSNNSK
                     FDELKNYINKSVYEENLRYEQEIIDEFSLINKTKVQFNAMD"
     gene            14316..14891
                     /gene="phnH"
                     /locus_tag="KNP36_002365"
     CDS             14316..14891
                     /gene="phnH"
                     /locus_tag="KNP36_002365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnH"
                     /protein_id="HBF0874230.1"
                     /translation="MVNYTQEIYRKMLDSASFPGKLNNIDNINIENNTNLLNGAIGIA
                     ITLLDQEVTFYIENYTQKDIKNIRALTMSNQIDYRKSDYIFLDINSEVDILQIKIGSF
                     EYPDESATIVHQVNDLSTYSQTKYIKLDLSGPGIKSKNSIYINGIREEFIERLSSINK
                     DYPIGIDLILVDKKGEIAFIPRSSKLSWEVL"
     gene            14894..16009
                     /locus_tag="KNP36_002366"
     CDS             14894..16009
                     /locus_tag="KNP36_002366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-phosphorus lyase complex subunit PhnI"
                     /protein_id="HBF0874231.1"
                     /translation="MAYVAVKGGEEAILQAKNILEFYRVKGDSLPIDVKQIEEQMSYA
                     VDKVMSEGSLYNKELSALAIKQAQGDILEASFYVRALRSTMPRITYSEPINTEEMRIK
                     RRISATFKDIPGGQYLGATRDYENRILNVELLEEDEKKNRHFRDSFINELETVDEIPE
                     FTKISNIFRKENLLQEEVCENKLEEVIDDITRNSLRFPVSRAAKLQALTRGESGVVSG
                     FAYAIVRGFGDEHPYISELRTGNVFIKIKHPIYEDEEITIGDMLVTECEIVSKASQNK
                     TENSKNNSEDKNKMSLGYGLCMGNNENKAISMAILDKSLEPNSEKLAQDEEFVLLHID
                     GIDSLGFISHFKLPHYVDFKADVERIKKFEEVSLGDI"
     gene            15999..16868
                     /locus_tag="KNP36_002367"
     CDS             15999..16868
                     /locus_tag="KNP36_002367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-phosphate
                     C-P-lyase PhnJ"
                     /protein_id="HBF0874232.1"
                     /translation="MIYNYGFLDENTKKEIRRKILKAISIPGYQVPFGSRELPIAKGW
                     GTGGLQLTLSLIGKNDVVKVIDQGSDDSTNACNIRSFIASVSNVETTKDTLEATLIQT
                     RHRIPEEKLKSNQILIFQVPIPETLRIVEPSEVETRRMHSEEDYSRMWVYLYEDIVRF
                     NDISIAVEYPCKVNDRYLMNPSPIPRFDIKKLNMSDNLFLFGAGREKRIYAIPPYTKV
                     EPLEFEDYKFEEEKFEGKYCSLCNSTNTFLDEVYDSDTNEKYYSCSDTSYCEKVRLKN
                     NSIDVTIGGTWNE"
     gene            16861..17727
                     /locus_tag="KNP36_002368"
     CDS             16861..17727
                     /locus_tag="KNP36_002368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874233.1"
                     /translation="MSKINDSKRLENIDKQVLIGRNINLIYGDGCEKCFESTGYESNN
                     ICKYCGSIVACNNVNLELYEGEVLGIVGESGSGKSTLLKILFFQEHANSGEVYISHYN
                     KDTNILELSDQKKRYIKNHFMGIVYQNPHLGLNLDFSSGGNIAEKLLMANLYNVEKIR
                     DRGKELLIKTNIPVERIDHKPKYFSGGMQQRVQIAKALSNNPPILLLDEVTTGLDVSV
                     QAEVLDLIREIQREFKISMIVVSHDFDVIKMLADRTIVMKNGSVIESGLTDQIMEDPQ
                     HPYTQQLINSLL"
     gene            17768..18481
                     /locus_tag="KNP36_002369"
     CDS             17768..18481
                     /locus_tag="KNP36_002369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0874234.1"
                     /translation="MKETILEVNNFSKDFELHALNKTITACSNISFEVSKGEFLGIIG
                     KSGAGKSTILKSIYKTYIPTTGEIIFNSEIYGNVDLAKIGDREMINLRKKEIGYVSQF
                     LKTLPRITAIELVVHSLIESGFEKDCSYDMAKDILNQFEIKENLWDAYPNNFSGGEKL
                     RLNLAQAMVKKPRLLLLDEPTASLDNQSKIYVKEKMLELKSQGTTMIGIFHDIEFMET
                     VIDKTFTMTKGTISESGVA"
     gene            18482..19651
                     /locus_tag="KNP36_002370"
     CDS             18482..19651
                     /locus_tag="KNP36_002370"
                     /EC_number="3.6.1.63"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate
                     5-triphosphate diphosphatase"
                     /protein_id="HBF0874235.1"
                     /translation="MIKLIHNANIVLEDMILENGHLIIEGDTIKKVSNDKIDYAFDFN
                     EIDEIIDAKNLYVIPGIIDIHSDAIEKEIEPRPSTLLPFNMAFYELDKKLPANGITTV
                     YHSISLGDGVGVRSIDNSLKMIKNIDSYKNIDSKSINHKVHLRYEVLYYEGLEKVLEL
                     LDENKIDYLSIMDHSPGQGQYTNPTFYKEYATKVWGVTENYVDTWLDDLVNLHDNLDW
                     NKIANIIGIAKTKNINVASHDDDTLEKMDFIKNIGINVSEFPITLEVAKHSKKLGVLT
                     CLGAPNIVRGKSHNNNLKAMDAILEDCCDIVCSDYLPSAMIKSMCIVAERINNLNKAV
                     SLFTSNPAKAVGIYDERGSIKENKKADLVLVDIDSEYPKVVNTIVNGKTVYKREV"
     gene            19655..20491
                     /locus_tag="KNP36_002371"
     CDS             19655..20491
                     /locus_tag="KNP36_002371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PHP domain-containing protein"
                     /protein_id="HBF0874236.1"
                     /translation="MLTELHCHTSISDNNFTTEEIIKKAAEKNINILAITNHDTLSGL
                     DEALVLGEHYGITIIPGIEISAYDYKNRKRVHILGYNIDLNSQEIKNLCNPMVCDRHK
                     ASVKMVNKIIDLGYKISLEDVKKYSSKTGIFKQHIMKALIDKGYTDNIYSSLYKELFH
                     RGNGKVYVSLKYVDYRDAIKAIKNSGGICVLAHPGQMDNFSAIEEMVKVGLDGIEVYH
                     PSHNKELEKESLSYAKKYNLVVTGGSDYHGFYSQHNYELGSKSLNKEDLFKFRLALGG
                     VL"
     gene            20492..21487
                     /locus_tag="KNP36_002372"
     CDS             20492..21487
                     /locus_tag="KNP36_002372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0874237.1"
                     /translation="MSFLQVKNVGKSYGQVKVLKDISIDIEKGEFICLLGPSGCGKST
                     LLRIIAGLEDKHGGKIIINDKDMTNSPPESRNFGIVFQSYALFPNMNVYKNIAFGLEN
                     KNISKSNIDKKVKEVLEVVELSGYEKKYPSQLSGGQQQRVALARAIALEPDFLLLDEP
                     LSALDAKVRLKLREQIRSLHRKLGITTIMVTHDQEEALCLADKMVVMNRGEIIQVGTP
                     KEVYKNPETPFVADFIGTINFIDDGINKIAIRPEDIKVESNRDSKDKDIKVGEILDIE
                     FRGFNYRITVEYRSKQMKLDVVSKVAEQMKLCIGSKINFKIPKEGIVQYKSEGCA"
     gene            21505..23193
                     /locus_tag="KNP36_002373"
     CDS             21505..23193
                     /locus_tag="KNP36_002373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     permease subunit"
                     /protein_id="HBF0874238.1"
                     /translation="MITSKNKRRISDSTIQKYFLIFSVIVLIVFILFPLVSLLKNAFM
                     DTSGNFIGISNFSKYVENPSLIASFKNSIFVSTVSSLISLCLAFIYSYAITRTNIKFK
                     EFFKTMGMFPLFAPTMLYGISLIYLFGNKGIFTTMGLEVPLYGPLGIIISQILFTFPQ
                     AFLILSVALSMADYRLYEAADSLGASEFKKFCKITIPGIKYSLLSSFFVSFILAFTDF
                     GAAKVVGGNYNVLATDIYKQVVGQFNIPMGATVSMVMLIPVLIAFTLDKMASKKQGMT
                     ITAKSMPYKIKENKFRDRVFLIVCSFITLLIFILIFVSVIGSVIKLWPYNLSFTMEHY
                     TFKGILGSGIKTYLSSLKISTLTAIFGTIFVFFSAYMIEKVDKFPKLRQTAYLLSMIP
                     MALPGLVLGISYITFFNSASNPLNFLYGSTAILVIVNVVHFYSVCFITSNSSLKMLDK
                     EYELVAKSINIPFYKVFFNITVPMSITSILEIVVYYFVNSMVTVSALIFLYTPQTQTA
                     SISILKLDEIGYIGPSAAMAVLVLLTNIIVRLLYEFVTKKLKNNTQKWQQKDVA"
     gene            23205..24272
                     /locus_tag="KNP36_002374"
     CDS             23205..24272
                     /locus_tag="KNP36_002374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative 2-aminoethylphosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0874239.1"
                     /translation="MKFKKLVSLGVLSTLLLSVITGCSTDSSGSDSKSDSKTKGDLTV
                     YTAIEEDSIEPYLATFKEKYPDIKLNIVRASTGDITARLLAEKDNPQADVVWGVAATS
                     LLVADDQGMLEPYAPKGSEEIESAFKDDKEVPSWVGIDAWMTGITVNTKELSDKNIPV
                     PSSYEDSIKPEYKGLISMPNPSSSGTGYLTVSALIQIMGEEKAWQYMDKLHENIGVYT
                     QSGSAPATSAASGEYPIGISFGYRGIKLKEEGYPVEVVFPKEGSGWDIEANALVKKDN
                     IKEASKVFLDWAISKDAMNEYSKNYAVTTISTGNPIPEGFPKKPLEQMIDNDLKSAAK
                     NREDILNKWISKYDGKTEKES"
BASE COUNT         9763 a         2750 c         4377 g         7587 t
ORIGIN      
        1 tattaaaaac ttaatagaaa tattaagcat aaagattatg tggttacaat agcagagagg
       61 atacacctgt tcccattccg aacacagaag ttaagctctc tagcgctgat ggtacttggt
      121 gggaaactgc ctgggagagt aggacgtagc cacgtaattt tttttatttt ttgtcaaaaa
      181 aaacaaaaaa tacgtatttc ttttttcatt tcgggaaaac taaacacagg aattatggac
      241 tttataaaaa tttaattctt gaggagtgat ataagtgaaa aaagttgctt taattttagc
      301 tataataggt gcgcttaact ggggtgcaat tggtattcta ggtacagact taataggtag
      361 tatctttggt ggaacatatg aaatggtaag tagaataata tacttcattg taggtttagc
      421 tggattatac ttaataccaa gtttaatgtc tgatgataga gaataattta tgcttttatg
      481 ttaaatacct cattctaaat gtttagaatg aggtatttaa ttttataaaa atattaattt
      541 gtttcttttt taatggtaaa atagataaga attgaagttt taaaaagaag tattatgtaa
      601 aaaaggagta ctattaatat atgtttatta ttaatgaatt aaataagatt gtaaatgaag
      661 aagtaatatc ttttcatatg cctggtcata aaaagggaca ggtttataaa aagttaggat
      721 ataaagatat actaaaaaat ttgtataaaa tggatacaac tgagatatta ggaacagata
      781 atttacactt tccggaagga attataaaaa attcacaaaa aaaagcatca agagtattta
      841 aaagtgatta tacttgctat ttagtaaatg gtagtagctg tggaatacaa tctgcaataa
      901 tgtcagtatg tagtcctaaa agtaaaataa taacaaatag agactgtcat cagtctgtta
      961 taaatggatg tattttagga gatatagata tagagtatgt gccttgtgag ataagtgaag
     1021 agacaaatgt cttaaaaggg atatctataa gtaatgtgat tgatataata gataaaaact
     1081 tggatgcaaa agcagtactg cttacttatc ctacatatta tggaatgaca tatgatttag
     1141 aatacatatg taattatgca catagcaaaa agatggtagt gatagtagat gaagcacatg
     1201 gtgcgcattt agggcttagc gagaggcttc ctaaaacagc tcttgagcaa ggcgcagata
     1261 tagttgtaca gagtacacat aaaactcttc cagcatttac acaatcgtca atgatacata
     1321 tacagggaga ccgagttgat atagataaaa tattgaacat gttaagaatt acagaatctt
     1381 caagcccttc atatttatta ttatcttctc tggaattagc agtagatata tatgaaaata
     1441 aaggaaaaga attaatggaa gagcttttaa ataatattat aactttcaaa aataaagttg
     1501 attcaaatat taatatatac gacacaaatg ataaaacaaa aatatttata tcatctaaaa
     1561 atatgggttt aacaggttat gaactagaaa atattttaag aaacaaatat aacatacaag
     1621 tggagttatc taattattat ggagttcttt taatatgtac aataggaaat actgttgagg
     1681 atttctctag tttagaaaca gcattaaaca atattgtaaa ggaagacttt aaatttgaaa
     1741 agttagaaaa taaaaaatac cctgttgtta ttccaaagaa aatattaaca cctagagaag
     1801 cattttataa aactaaaaaa agtgttaaaa tatatgacag cataggtaaa gtttgtggtg
     1861 aatgtatagt tccataccca cctggaataa gtgtaatatc tcctggtgaa gtaataagta
     1921 aagaaataat agactatcta atgttttgtc attctaaagg catgattgtg agtggattga
     1981 aagatgtaga tttaaatttt atacaaataa tagatttaga agacatttaa aaattatgat
     2041 ataaaagtag atagaagtag atagtttaaa attgtgaaga gaaataaata gactgcttat
     2101 atagagctat ctaataaaag tactaaaaaa gtaaaaagtg tttgtatgga ggatatgaaa
     2161 atgaaaggta agttaataat tatagagagt ggttcagatg caagtggaaa ggctactcag
     2221 acagaaatat tatatgaaag attaaaaaaa gaaggctata tgattaaaaa ggtagaatat
     2281 ccaaattatg aatctccatc atctgccttg gtgaaaatgt acctaaaagg agactttggt
     2341 aaaaatgcat cagatgtaga cccatatata gcatcaactt tttttacagc tgataggtat
     2401 gcatcattta aaaccgattg ggaggagttt tacaatgaag gtggaataat tatcgcagat
     2461 agatatacaa cctctaatat ggtacatcag gcctctaaaa tggatatttg tgatagagaa
     2521 gagtatttaa attggttagc tgattatgaa tttaatttat ttaagatacc acaacctgat
     2581 tgtgttatat ttttagatgt gcctattgaa tttagtaaaa agcttatgga gaatagaaaa
     2641 aataaaatta caggggaaga aaaaaaggat attcatgaaa gtgacataga gtatttagag
     2701 aaatcttaca acaatgcttt atatatagca gataaatatg attggaaaaa aataaattgt
     2761 gttttagata acaaattaag aagtattgaa agtatacata atgaaattta taaaatagtt
     2821 cttgattcaa taaaacctat ggagagataa atatgtattt tgaaaatatt atagggcaag
     2881 attttgcaaa gaaatattta acaaattcta taaagaaaaa taaacttaat aatgcgtata
     2941 tgtttgaagg aatggatgga ataggaaaaa agaaatttgc agatgaatta tcaaaactat
     3001 tacttgatta tgaaaatctc gaaaatagtc cagactatgt actcataaaa ccagatggaa
     3061 atagtataaa aatagctcaa atcagaaatt tacaatcaga tatagtaata agacctcata
     3121 aagactataa aatatatata atcaataatg ctgaaaaaat gactgtggaa gctcaaaatg
     3181 cacttttaaa gacgctagag gaacctccaa actatgctat aataatctta gtcacaaaca
     3241 acaaggaatc tttattagaa actataaaat ctagatgtga tataataaag ttctcaccta
     3301 taccaattga agacttaaaa cgttatttga taaatacagg tatagaagaa gaaagagctc
     3361 aattattggc tattttttcg agaggaagta ttgagaatgc tctaaatcta tctcagtctt
     3421 ctgagttttc aatgatgaga gaagatatac aacagtatat tcagataatg ttagataaaa
     3481 acatagtgga gattttaaat ataccaaata atatggaaaa atatagaggt aagattatag
     3541 ctttattaga tatgatgata aactattttc gagatatcat cctattaaaa gaaaatgtaa
     3601 acaagaacat gttaataaat gtagataagc tagttttcat tcaaaatatg agtggaaaaa
     3661 ttagttattc tcaattgtcc aagattattg atataataga agatgcaaag agtaaaataa
     3721 aaagcaattg caatttcaat ataagcatac aagttatgtc tttaaatata tacgaggtga
     3781 ttaaatgata aagatagtag gtataaggtt taaaagtgct gggaaaatat attattttga
     3841 ccctgttgat tttaatatag agcaagatat ggatgtagtt gtagaaactg caagaggctt
     3901 ggagtatggg aaagtagtcg ttggtccaaa agatatggat gaaagcgaat tagtttctcc
     3961 tttgaagcca attataagaa tagctacaga agaagataaa aaagtatatc tagaaaataa
     4021 ggaaaaggca aaagaaactt ttgagttgtg ccaacaaaaa ataaaagaac atgagttaac
     4081 aatgttttta atagattgtg agtatacatt tgataggaat aagttgattt tttactttac
     4141 agcagaagga agaatagatt ttagagaatt ggtaaaagac ttagctgcta tatttaaaac
     4201 tagaatagaa cttagacaaa taggtgtcag agatgaagct aaatctatag gaggtctagg
     4261 gccttgtggt agaaaacttt gttgttcatc ttggttaggt gattttcaac cagtttcaat
     4321 aaaaatggca aaagaccaaa gtctatctct aaatccaaca aaaatatctg gaatatgtgg
     4381 gagattattc tgttgcttaa aatatgagca tgatgtatat agtgaagcaa tagaaaaaat
     4441 gcctgttgta ggtgcattgg tgcaatcaga tgatggaaaa ggaaaagttg tagaagtgaa
     4501 tcctttatta gaacaaatta aagtggaatt tcaagacaag acagtaaaga tatacacaag
     4561 agaagatata aaaatactta gagagcctaa aaaatgtgat ggctgtggtg gtaaatgtaa
     4621 ggataatgat ggattagatg aagccacact aagagagcta aagaaattag aagattaaat
     4681 ttaaggtagg gcttttccta ccttttttaa agcaattaat gcttaaagtt attaatattt
     4741 gaggagaatt tatatatgca attaaaagat tcagaaagaa tagatgattt acaattaaaa
     4801 ggccttaaaa ttatacaaga tactaatggt ttttgttttg gtatagatgc agttttatta
     4861 gccaatttta ctaaaataaa aaaagatgcc aaagtagtag atttgggtac tggaactgga
     4921 attataccta ttttgatagc tggaaaaagt gaagctaaaa aaattattgg cgtggaaata
     4981 caagaagatg tatatgaaat ggcaactcgt tctataaaat taaatggatt agaagaaaga
     5041 gttgagatta taaatgaaga tataaaatac atagacaaag tcttagacat aaatggttac
     5101 catgtagtca catcaaatcc tccatatatg catattgatg gaataaaaaa tccaaatgat
     5161 aaaaaagcaa tatcaagaca tgaagtaagg tgcaatttgg aagatgtaat tagagctgca
     5221 tccagattgg ttatgcctag aggaaaattc ttcatgatac atagaccaac aagattggtt
     5281 gatataataa ctttagggag aaaatataaa ttagaaccaa aggttattca atttgtgcat
     5341 ccaagacctc aaaaagcacc gaacttagtt ttggttcaat ttgtaaaaga tggaaggcca
     5401 gagcttaaaa tattggaccc attgtatgtt tatggagaag atgggaatta tacaaaagaa
     5461 ttaaaagcaa tatataataa taaagatata ggagagttgt aaatgagtgg gaaattgtac
     5521 atatgtccaa caccaatagg aaacctagaa gatataacat atagaacttt aagaacatta
     5581 aaagaagtag acttgattgc agcagaagat acaagacata gtataaaact tttaaatcat
     5641 tttgaaatct caaaaccact aactagttat catgaacata ataaggattc aaagggagat
     5701 tatttgataa ataaactaat tgatggtgaa aatatagctc tgataagtga tgcaggtatg
     5761 cctggtatat ctgacccagg agaagagata ataaaacaag ctatacaaaa taacatagag
     5821 atagaagtat tgccaggtgc aacagccttt gtaacggctt tagttggctc tggtatggac
     5881 acacatagat ttgtttttga gggcttttta gatagagata aaaaagttag gaaagcacaa
     5941 ttggaagaat taaaggaaga aagtagaact ataattttct atgaatcacc acatagattg
     6001 aaggatacac taaaagatat gcttaaaatt cttggtaata ggaatatttc tataaataga
     6061 gaacttacaa aaaaatatca agaaataata agagaaaata tagaaactac cataaaaata
     6121 tttgaggaaa aagaaataag aggagaattt gtattaatag tagagggttt tcatggtgag
     6181 aagtcaaaga aagaaaatta tgatgggctt acagataggg aatatgtttt aaaactaatt
     6241 gaaagtggta tgaacaaaaa agatgcaata aaaatagttt gtaaagatag aaagttaaag
     6301 aaagatgtgg tttataaaca agttttagat ttataaaacc tgaatctgag gtgattttat
     6361 ggaaataggg aaaattataa tagagagttt aaagagggaa gatacacata aaatatttat
     6421 agaattagat aataagcatg aattagaaaa aataattcct aaaataagct gtatgaagtc
     6481 tgtaggtgaa tgtaaatatc atgtagtaaa ttgttttgaa cattctataa acgcattaaa
     6541 agaattagaa atagtattaa atgataagga tttttttcca atacatctaa gaaaacatgt
     6601 gtcaaactat ttaaacacat atattgaaga aggaataaat aagttacatg tattaaagct
     6661 gggaacattt ttacatgata taggtaagcc tgacagtatg accttagatg aaaccggaag
     6721 agttcatttc acaaatcatg aaaaaatagg tgctcaaata attgacaata tgggaataaa
     6781 gttagagtta tcaacagaga catatagact tataagtaaa tatgtaagat atcatatgat
     6841 acttttgtct ctatataaga aaaatgattt gagtaggaaa gaattaatta atgtatttaa
     6901 cttagtagat gaggacacta taggtgtaat aatgcttggg tatgcagata tagtgtctac
     6961 agtaaaatta ttgggcaaga gtggagaagt cagtgtgtta aagacatata tggaatatat
     7021 tttaacaaat tacttgtata agagtaatta tacacatgta taaatttagt taatataatt
     7081 gagttttaga tgattaattg aagtttgaaa tatacggatt tcaaaaacat aaaagaagtt
     7141 gtctttgttg taaaattatg aaagacaact ttttttatat caaaaattga aattttatta
     7201 aggatactta atggtctatt aattaataaa ccattagtat ttaatttata ttacaatatt
     7261 gattttgctt gtattggcgt tgatagtata acagaggtct tagtagaacc aattttcttt
     7321 atagtatcaa tcacattttc taactcgtac atatctttta caattacttt taaaagtaag
     7381 caatcatcac ctgttatatg gtgacattct acaatcctag ggtcctttgc agctgactca
     7441 ataaattctg tatatccatt gcttggaaga gaaatatgaa taaatgcctt tataactctg
     7501 cctaatgaat ctgggttgac aatagcttta tatccttcta taacaccaga ctcttctaat
     7561 cttttgactc tttctgaaac tgcaggagaa gttaaaccaa ctatttttcc taagtccttc
     7621 atagaaattc tcccatcatc ctgtaaaatt tctatgattc tgtaatctgt aacatccata
     7681 aataaacagt cccccttaaa taaaaataat taatgctata aaactttttt agaatctatc
     7741 atttgtgttt ttaaatacca aagatttcta gataaatcaa ccttataaat gtgtggtttt
     7801 gaaagtcttt tgtattgttc ccagatagta cttaattcat attgtacatg attttttatt
     7861 tcaagaacag cttttttatt atatttgcat ctgcctttta tatacaatgg tttaagaagc
     7921 tctttaactt tgtaatttgt aaataccttc gttttccatg tataagtagg atggaagatt
     7981 tctaaaggtt tagactcatc tataacttca tcatgtaaca taatcaaatc tgcctctgcc
     8041 ttattgtctt cgttatatat tcttataact ttcttgtaac caggattatt tattttttct
     8101 ggattctcag aaatctttat cttaggttca agaactcctt tttcacaaga tgcagctaat
     8161 ttataaactc ctccaagaga aggtgaatcg aaagatgtaa tgagctttgt acctactccc
     8221 catgaattta tagtagctcc ttctgcttta agtgatgtta tggtatattc gtctaggtca
     8281 ttagatgcag tgatgctgat atctgaaaag ccagcattat ctaattgttt tttagcttct
     8341 ttagataaat aagctaaatc tccagagtca agtcttatac ccataggttt gtatcctttt
     8401 tcagaaatat ttttgaatac ttttattgca ttaggaactc cactgtttaa tacatcataa
     8461 gtatctacaa gtagtaggca tttatctgga taaacatcag catatgcttg gaatgcttca
     8521 agttcattat caaatttttg tacccaactg tgagcttgtg taccaattat aggtatatca
     8581 aacattttcc ctgctagtac gtttgcagtt ccagcacaac caccaactac agcagcccta
     8641 gccccatata tccctgcatc tggaccttgt gcacgacgta atccaaattc aaatacaggg
     8701 tctccttgag ctgcaaagca aactctagag gctttagtag caataagaga ctgaaaatta
     8761 actattgtta acaatgctgt ttcaataagt tgagcttgat ataaaggtgc cttaacagta
     8821 attaatggct cattagggaa catgatagtt ccttcctcaa cagcatatat atctcctgtg
     8881 aatttaaatt cttttaaaaa ttttaagaac ttgtcagaaa ataaatttaa gttttttaag
     8941 tactctaaat cttcatctga aaaatgaaga ttatctatgt attcaacaac ctgatcaata
     9001 ccacaaacta tagtataccc tccatcacaa gcgttttttc taaaaaacat atcaaataca
     9061 acaatgtctt catgaatatt cttttcaaaa tagccattta acatagtaag ctgatataaa
     9121 tcagtaagaa gtgttagatt tctcattatt tctctcctta attattatta aatattaaaa
     9181 attgtaaaaa ctcccacact tatactaaaa cataatatag tacaactttc aagtataaag
     9241 tattacctaa ctatcataaa attatttaaa gaggaggatg attataatag gaaaaatatg
     9301 gttttatatg gtatcgatag gaataatagg aagcttgatt tctaaaaata tgggtgaatt
     9361 aaataaagtt atattaagtg aaacatcaaa aggtatagag tttgcaataa gtctagctgg
     9421 tatcatggca ctctggatgg ggataatgaa tatcgcaaaa gaatcaggtt taattgaaaa
     9481 gataggtcaa aaactaaatc ctataatgag aagattattt ccttctattc caaaaggtca
     9541 taaagcaatg tcttatatag ttatgaatat tgctttaaat atgttgggtg ctggaaatgg
     9601 tgcaacagca tttggtttaa aagcaatgag tgagcttcaa actttgaata acaagaaaga
     9661 tacagccact aatgatatga ttatgtttat ggtaatcaat atatcatcta tacaaataat
     9721 tccatttacc ataatcaaac taaggatgga tatgggggct caaaatccaa gtgaaataat
     9781 ttttacgact ttatttgcaa ccataatatc tacagcagta gcaataataa catgtaaatt
     9841 ttttcaaaga agatatagat aaaggggatg tagatacatg gagatatttt caaacttact
     9901 tataccaata ataattctgt acatagtaat ttatggtaaa tataaaaaaa tagatgtgta
     9961 tgatagtttt gtaaaaggag caattgatgg attaaaagct gcatgggata tcctaccata
    10021 tataataggt atatttttgg caataggaat attcaaaact ggtaaaggtc ttgatatgtt
    10081 agaatggcta tttacaccaa tagcaaatat gatgagtata ccaaaagaat taataggtct
    10141 aataagtgta aaacctttat ctggaagtgg tgctttaggg atgtacagtg aacttgcaaa
    10201 tagagttgga ataggaagtt tagtagaaaa aatgggtgct acgattgtag gttcttctga
    10261 gactattttt tacacaatgg caatatacta tggaagtctg aagataaaaa atactagaca
    10321 tacattatca tgtgctatga ttagccatgt tgcaggtgtc atagcagctg tttttatttg
    10381 ctatgtaata tttgtataat ttgttgacaa tatgggaaaa attttataat atagtgatta
    10441 tatagaaaca aatagtaata caaattacaa gctatgaaaa gaagagtaaa taaaggtttt
    10501 ttctatcaga gagctaggtt aggtgaaagc tagtgtcaaa agctttattg aagatggtct
    10561 tggagctttt tatctgagca agtgtgctag ggtaaaacgg ttggacacgt tatagtctac
    10621 taaggtatct ataaaatgtt tctacatttc atgtgaaaca taactattat agatgaatta
    10681 gggtggtacc gtgaataatc tcgcccctat gttaactcat aggaggcgat tttttattat
    10741 ttaaatgaaa gaatcatatg attacgaacg ataaaaaatt aggaggtaaa taacatgagc
    10801 aaaccgagtt tttatgtaac aacaccaata tactatccaa gtggaggatt acacatagga
    10861 catacttatt caacagtagc tgcagataca atagctagat tcaagcgttt ctgtggatat
    10921 gatgtaaagt tcttaacagg aacagatgag catggtgaaa aaattcaaaa gaaagccata
    10981 gaacaaggaa tgtcagagat agagtatctt gatggaatga taaaagatat aaaggcctta
    11041 tggaatacta tggatatatc ttatgatgat tttataagaa ctacagaaaa aagacataca
    11101 gacataatac aaaagatatt tactaaacta tatgagcaag gtgatatata taaaggtgaa
    11161 tatgaaggta gatactgtac tccttgtgag agtttctgga cagaatctca attactagaa
    11221 ggaaataaat gccctgactg tggaagagaa acatatttag taaaagaaga atcttatttc
    11281 tttagattat ctaaatatga agacagatta aaagagttat ttaaagatga tagtttctgt
    11341 tttcctgctg ctagaaaaaa tgaaatggtg gcaaactttt tagacaaagg attagaagat
    11401 ttaagcgtaa ctagaacgac ttttgactgg ggtataaaag ttccttttga tgaaaaacat
    11461 gtaatttatg tgtgggtaga tgctttatgt aactatataa cagcattagg ttatatgact
    11521 gataatgatg aagaatttaa aaaatattgg cctgccaatg ttcaaatagt aggtaaagaa
    11581 atagtgagat tccatacaat aatatggcca gcgcttttaa tggctttagg tctagaagtt
    11641 ccaaaacaag tatttggaca tggatggata ctatttgctg atgataaaat gagtaaatca
    11701 aagggtaatg tggtttatcc agaacctata atagaaagat atggaataga cacacttaag
    11761 tacttcttat taagagagtt tgcatttggg caagatggaa gttatactca tagaaatttt
    11821 gtaacgagaa taaattatga tttagcaaat gatttaggaa acttaataag tagaactgta
    11881 gctatggttg aaaaatacaa taatggtata ataccaacag caaaagtttc aactgatttt
    11941 gatgctgact taaaagaaca agctgtttca actagagaaa actttgaagc tgaaatggat
    12001 aaaatgcaat tccatgaagc attagagagt gtatggaaat tagttagaag aactaacaaa
    12061 tatatagatg aaactatgcc ttgggcacta gctaaagatg aaacgaagaa agatgaatta
    12121 gacacagttt tatataattt atgtgaatct ataagaataa tcgcaacact aataaatcct
    12181 ataatgaatg agactgctaa taaaatatat gaacatatag gaataaaagg tcaagatgat
    12241 ataactacat gggaaagtac aaaaacattt ggtcttattg gagaaaatgt aaaagtattt
    12301 aaaggtgaac ctttattccc aagattagat gtagaaaaag agatagaaga attaactaaa
    12361 atgttctctg ggaaacctcc agtagaagaa aaacctttag agcataaaga agaaattact
    12421 attgatgatt tagacaaaat agagcttaga gtagggaaaa taataagctg tgaaaaacat
    12481 ccaaaagcaa ataaattatt agtatcacaa gttaagattg gaccagaaac aagacaaata
    12541 gtatcaggaa tagctgaata ctataagcca gaggatttag taggaaaaga ggttacagtg
    12601 gtatgtaact taaaaccagt taaattaaga ggtgtagaat ctcaaggtat gatattagca
    12661 gcaggtgatg atggagaccc atatgtttta ccatttacac aaggggctaa agatggatgc
    12721 gaggttcgtt agtaggtaat taaatagtaa ggagattaaa gatgttattt gactcacatg
    12781 cacatttaaa tgatgaaagt tttgatgaag atagagatga acttattggt tcattaaaag
    12841 ataaaggtgt agatttggtt gtaaatccag gagcagatat agagacgtcg ataacagcaa
    12901 ttgaacttgc gaaaaaatac gactttatat attcagcagt tggggtacat ccacatgatg
    12961 tatcaaaact agatgataca gcaatagaaa ctctaagaaa acttgcaact gagaatgaaa
    13021 aagttgtagc tattggagag attggattag attattatta tgattattct ccaagagaag
    13081 aacaaaaaga gtggtttaag aagcaaattg aattagctaa tgagctaaaa cttccaataa
    13141 taatacatga tagagatgca catggagata cttttgagat aataaagaat actaaaaatc
    13201 ctgaaatagg atgtgtactt cattgttata gtgggaatgt agagttagct agagaatatg
    13261 ttaagatggg ttgttatata tcaattccag gcacggttac ttttaagaat aataaaaaaa
    13321 ctagagaagt agtaagagaa atacctctag aaagattatt catagagact gattcaccat
    13381 atatgtcacc agagccacat agaggaaaga gaaacaatcc ttcccaagta tcttttgttg
    13441 ctgataagat agcccaggaa aaagggatat cttatgaaga agtatgtaga gttacaaaag
    13501 aaaatgcaaa gaaatttttt aatataaaat agacaaatta aatcttataa tgatatatat
    13561 aataagtcat tataagtata ggatgagagt gcctcaaaat gagtttttta gttcatgagg
    13621 cactcttttt tgtatgaaat caaatatatt ttcatcattt caacaatgaa aaagaagttt
    13681 atcatatttt gagatagttt gtttttattt atttaattca tattttaaaa tatattttct
    13741 taacattgtt aaaaaagaat ttacaagaga ttcattagaa ttaactcaac tctaatattc
    13801 acttaactta agttgtttat tatattatta aagagaagta aacgaaaggt agattaagga
    13861 ggttgaattt tgtatacagt tgatagtact aagatattga taaatatgaa cttagagaaa
    13921 ctagaaaaga tatactcaat gataaaagat acatcaagta tttctataat taaagaacct
    13981 aacttggcta cagtaatggt aagagctaat gaaagtgtaa aaaacacaac atttaattta
    14041 ggagagatat tagttactga atgtagtgta aaggtagatg aaagcttggg ttacggaata
    14101 gtttcagaaa acaataataa gaaagccatt tatttagcag ttatagatgc agttttacat
    14161 agcaataaca gtaaatttga tgagttaaag aattacataa ataaaagtgt atatgaagag
    14221 aacttaaggt atgaacaaga gattattgat gaatttagct tgattaataa aacgaaagtt
    14281 caattcaatg ctatggatta aataggagga gaatcatggt aaattataca caagaaatat
    14341 atagaaagat gctagatagt gcttcatttc ctgggaaatt aaataatata gataatataa
    14401 atatagaaaa taatacaaat ctattgaatg gagcaattgg tatagcaatc actttattag
    14461 accaagaagt taccttctat atagaaaatt atactcaaaa agatataaaa aatataagag
    14521 cacttacaat gtcaaatcaa atagattata gaaaatcaga ttatatattt ttagatatta
    14581 attcagaagt ggatatatta cagattaaaa taggttcttt tgaatatcct gatgaaagtg
    14641 caactatagt acatcaagta aatgatttat caacgtactc tcaaactaag tatataaagc
    14701 ttgatttgag tggtcctggt ataaaatcta aaaatagtat atatataaat ggaattagag
    14761 aagaatttat agaaagatta tctagtataa ataaagatta tccaatagga atagatttga
    14821 ttttagtaga taaaaaagga gaaattgcat ttataccaag gtcatcaaaa ttaagttggg
    14881 aggtattata gaaatggctt atgtagcagt taaaggtgga gaagaagcca tattacaggc
    14941 taaaaatata cttgagtttt atagggtaaa aggagatagc ttgcctatag atgtaaagca
    15001 gattgaagaa caaatgtctt atgctgtaga caaagtaatg tctgaaggaa gtttatacaa
    15061 caaggaacta tcagcattgg ctataaaaca agctcaaggt gatatattag aagcctcttt
    15121 ctatgtaaga gctttaaggt caacaatgcc tagaattaca tattcagaac ccataaatac
    15181 agaagaaatg agaataaaaa gaagaatatc agctactttt aaagatatac caggaggtca
    15241 gtatcttggg gcaactagag actatgaaaa tagaatattg aatgtagaat tattagaaga
    15301 agatgaaaaa aagaatagac attttagaga tagttttata aatgaattag aaacagtaga
    15361 tgaaatccct gaatttacaa aaatatctaa tatatttaga aaagaaaatt tattacaaga
    15421 agaagtttgt gaaaacaaat tggaagaagt tattgatgat attacaagaa atagtttaag
    15481 atttccagtt tctagggcag caaagttaca ggcattaact agaggtgaaa gcggagtagt
    15541 atcaggtttt gcttatgcta ttgtaagagg ctttggtgat gaacatccat atataagtga
    15601 acttagaact ggcaatgtgt ttataaaaat aaaacatccc atctatgaag atgaagaaat
    15661 aacaataggt gatatgttgg ttactgaatg tgaaatagtt tcaaaagcat cgcaaaataa
    15721 gactgaaaat tctaaaaata attcggaaga taaaaataaa atgtctttag gatatggtct
    15781 ttgtatgggg aacaatgaga ataaggctat atctatggct atactagaca aatctttgga
    15841 gccaaatagt gaaaaactag cacaagacga agaatttgta ttgcttcata tagatggaat
    15901 agattcatta ggatttatat ctcactttaa gcttcctcac tatgtagatt ttaaagcgga
    15961 tgtagaaaga ataaaaaagt ttgaggaggt aagtttaggt gatatataac tatggttttt
    16021 tagacgaaaa cacaaaaaaa gaaataagaa gaaagatatt aaaagcaata tcaatacctg
    16081 gttatcaagt tccctttggt tcaagagagt tgcctatagc taagggatgg ggtactggag
    16141 gtttacaatt aacactatca ttaattggta aaaatgatgt agtaaaagta attgaccaag
    16201 gaagtgatga ttctacaaat gcttgtaata taaggagctt tattgcaagt gtaagtaatg
    16261 tagaaaccac aaaagataca ttagaagcta cattgattca aacgagacat agaataccag
    16321 aagaaaaact taaatctaat caaatactaa tatttcaagt accaatacca gaaaccctta
    16381 gaatagtaga acctagtgaa gtagaaacaa gaagaatgca ttcagaagaa gattatagta
    16441 ggatgtgggt atatctttat gaagatatag ttagatttaa tgatatatct atagcagttg
    16501 aatatccatg taaagtaaat gatagatatt taatgaatcc atcacctata cctagatttg
    16561 atataaaaaa attaaatatg tcagacaatt tattcttgtt tggtgcaggt agagaaaaaa
    16621 gaatttatgc tattcctcca tatacaaagg tagaaccttt agagtttgag gattataagt
    16681 ttgaagagga aaagtttgaa ggaaaatact gtagtttatg taacagtaca aatacatttt
    16741 tagatgaagt atatgacagt gacactaatg aaaagtacta tagttgctca gatacaagtt
    16801 attgtgaaaa agttagatta aaaaataaca gtatagatgt gacaatagga ggtacttgga
    16861 atgagtaaaa taaatgactc taaaagatta gaaaatatag acaagcaagt attaatagga
    16921 agaaatatca atcttattta tggagatggg tgtgaaaagt gttttgaaag cacaggatat
    16981 gaaagcaata atatatgtaa gtattgtggt tctatagttg catgtaataa tgtaaattta
    17041 gaactttatg aaggagaagt ccttggaatt gtaggtgaat ctggttcagg aaaaagcact
    17101 ttattaaaaa tactgttttt ccaagaacat gcaaatagtg gagaagtata tatatcccat
    17161 tacaataaag acacaaatat actagagctt tcagaccaaa aaaagagata cataaagaat
    17221 cattttatgg gtattgtgta tcaaaatccc caccttggtt taaatttaga ctttagtagt
    17281 ggtggtaata tagcagaaaa attattgatg gcaaatttat ataatgttga aaaaataaga
    17341 gatagaggca aagaactttt aataaaaact aatatacctg tagaaagaat agaccataaa
    17401 ccaaaatact ttagtggggg aatgcaacaa cgagttcaaa tagcaaaagc tctttcaaat
    17461 aaccctccaa tattgctatt agatgaggtt acaacaggtt tagatgtttc tgtgcaagcg
    17521 gaagtattgg atttaataag agaaatccaa agagaattta agatttctat gatagttgta
    17581 tcccatgact ttgatgttat aaagatgctt gctgatagga caattgtaat gaaaaatgga
    17641 agtgtaattg agtctggtct tacagaccaa ataatggagg acccacaaca cccatatact
    17701 cagcaactta taaattcatt gctataaata tcgtttgtaa ataagcaaaa tgggggtttt
    17761 taataaaatg aaagaaacta tacttgaagt aaataatttt agtaaagact ttgagttaca
    17821 tgcattgaac aagactataa cggcatgtag taatataagt tttgaagttt caaaaggtga
    17881 gtttttagga ataataggta aatctggagc aggtaagtct accatattaa aaagtatcta
    17941 taaaacatat ataccaacaa ctggagaaat aatttttaat tcagaaatat atggtaatgt
    18001 agacctggct aaaattggag accgagaaat gataaatctt agaaagaaag aaataggata
    18061 tgtatcacag tttttaaaga cacttccacg aataactgca attgaactgg tagtacattc
    18121 tttaattgag agtgggtttg aaaaggattg ttcgtatgat atggcaaaag atatacttaa
    18181 ccaatttgaa ataaaggaaa atttatggga tgcgtatcca aataattttt ctggtggaga
    18241 aaaattaaga ttaaatttag ctcaagctat ggttaaaaag cctagacttt tgttacttga
    18301 tgaaccaact gcatcacttg ataatcaatc taaaatatat gtaaaagaaa aaatgttgga
    18361 gcttaaaagt caaggaacta caatgatagg aatttttcat gatatagagt ttatggaaac
    18421 tgttatagat aagaccttta ctatgacaaa agggactata agtgaaagtg gggtagccta
    18481 gatgataaaa ctaattcata atgcaaatat tgtattagaa gatatgattt tagaaaatgg
    18541 tcatttaatc atagagggag atacaataaa aaaagtatca aatgataaga ttgattacgc
    18601 atttgacttt aatgagatag atgaaataat agatgcaaaa aacttatatg taatacctgg
    18661 tattatagat attcacagtg atgccattga aaaggaaata gagccgagac caagtacatt
    18721 attaccattt aatatggcat tttatgaact agataaaaaa ctacctgcaa atggaataac
    18781 tacagtttat cattctatat ctttagggga tggagtagga gttagaagta ttgataactc
    18841 tttaaagatg attaaaaata ttgattcata taaaaatata gatagtaaga gcataaatca
    18901 taaagttcat ttaagatatg aagtgttgta ttatgaaggt ttagaaaagg ttttagaact
    18961 attagatgaa aataaaatag actacttatc aataatggac cattctccag gacaaggtca
    19021 gtatacaaat ccaacatttt ataaagagta tgctactaaa gtgtggggag ttacagaaaa
    19081 ttatgtagat acatggttag atgatttagt aaatctgcat gataatttag attggaataa
    19141 aatagctaat attataggta tagccaaaac taaaaatata aatgttgcat cacatgatga
    19201 tgatacatta gaaaaaatgg atttcataaa aaatataggc ataaatgtat ctgaatttcc
    19261 tataactctt gaagttgcaa aacattcaaa gaaattgggt gttctaactt gtttaggtgc
    19321 accgaatatt gtaagaggta aatctcataa taacaattta aaagcaatgg atgctatatt
    19381 ggaagattgt tgtgacattg tgtgttcgga ttatcttcca tcagctatga taaagtctat
    19441 gtgtatagtt gcagaaagaa taaataattt aaataaagca gtcagtttat ttacctcaaa
    19501 tcctgctaaa gcagttggta tatatgatga aagaggtagt ataaaagaaa ataaaaaagc
    19561 agatttagtt ttagtagata ttgatagtga atatccaaag gttgtaaata ctattgtaaa
    19621 tggaaaaaca gtttataaaa gggaggtata aagattgcta acagagttac attgtcatac
    19681 aagtatatca gataataatt ttactactga agaaataata aaaaaagcag cagaaaagaa
    19741 tataaatatc ttagcaataa caaatcatga cacattatct ggattggatg aagctcttgt
    19801 gcttggagag cattatggaa taacaataat accaggtata gaaatttcag cctatgatta
    19861 taaaaataga aaaagagttc atattcttgg atataacata gatttaaaca gtcaagaaat
    19921 aaaaaatttg tgcaatccaa tggtatgtga cagacataaa gcatctgtta agatggtaaa
    19981 taaaattata gatttaggat acaaaatatc tttggaagat gtaaagaaat attcatcaaa
    20041 gactggaata tttaaacaac atataatgaa agctcttata gataaaggat atacagataa
    20101 tatatattca agtctatata aagaattgtt tcatagagga aacggcaagg tatatgtatc
    20161 tttaaaatat gtggattaca gagatgcaat aaaagctata aaaaattctg gtggaatttg
    20221 tgtgttagct cacccgggtc aaatggataa ttttagcgct attgaagaga tggtaaaagt
    20281 aggattagat ggaatagaag tatatcatcc atctcacaac aaagaactag aaaaagagtc
    20341 gctttcttat gctaagaagt ataatctagt ggtcacagga ggctcagatt accacggatt
    20401 ttattctcaa cataattatg aacttggaag caagagctta aataaagaag atttatttaa
    20461 gtttaggtta gctttaggag gggtattata aatgtctttt ttacaagtaa aaaatgtagg
    20521 taaaagttat ggacaagtta aggtgttaaa agacatatct attgatattg aaaaaggaga
    20581 gtttatttgt ttactaggtc caagtggttg tggaaaaagt acactgctta gaataattgc
    20641 agggcttgag gataaacatg gtggaaaaat aataataaat gataaggata tgactaattc
    20701 accacctgaa agtagaaatt ttggtatagt ttttcaatca tatgcattat ttccaaatat
    20761 gaatgtttac aaaaacatag cctttggact agaaaataaa aacataagta aatctaatat
    20821 tgataaaaaa gttaaagaag ttctagaagt tgtagaatta agtggatatg agaaaaaata
    20881 tccatcacaa ttatcaggtg gacaacaaca aagggttgca ttagctcgtg cgattgcttt
    20941 agagccagac tttttacttc ttgatgaacc tttatctgca ttagatgcaa aagtaagact
    21001 taaacttagg gagcagatta gaagtttgca tagaaaacta ggcattacaa ctataatggt
    21061 aacgcatgac caagaagaag ctctttgttt agctgataag atggttgtta tgaatagagg
    21121 agaaataata caagttggaa cgccaaagga ggtatataaa aatccagaaa caccttttgt
    21181 agctgatttt ataggaacaa taaattttat agatgatggt attaataaga tagctattag
    21241 accagaagat ataaaagtag agtctaatag agattctaaa gataaggata taaaagtggg
    21301 agaaatttta gatatcgaat ttagaggatt taactataga attacagttg agtatcgttc
    21361 taagcagatg aaattagatg tagtttccaa agttgcagaa caaatgaaac tgtgtatagg
    21421 ttctaaaata aactttaaga tacctaaaga aggaattgta caatataaat cagagggatg
    21481 tgcttaatag ctaggggtga ataaatgata acatcaaaaa ataaaagaag aataagtgat
    21541 agcacaatac aaaaatattt cttgattttt tcggtaattg tactaatagt atttatatta
    21601 tttccattag tatcattatt aaaaaatgca tttatggata caagtggaaa ttttatagga
    21661 atttcaaact ttagtaaata tgttgaaaat ccaagtctta tagcatcatt taaaaattca
    21721 atttttgtat ctacagtctc atctttaata tcactatgtt tagcatttat atattcatac
    21781 gcaataacaa gaacaaacat aaagtttaaa gaatttttta aaactatggg aatgtttcca
    21841 ctttttgcac caactatgtt atatggtatt tcacttatat acctttttgg aaataaggga
    21901 atctttacaa ccatgggtct ggaagtacca ctatatggtc cattaggaat aattatttct
    21961 cagattctat ttacatttcc acaagctttt ttaatattat ctgtagcact ttcgatggct
    22021 gattacagac tttatgaagc agcagatagc ttgggtgcta gtgaatttaa gaaattttgc
    22081 aaaataacaa ttcctggtat aaagtactca ttacttagtt cattctttgt atcctttata
    22141 cttgcattta cagattttgg agcagctaag gtagttggag gaaactacaa tgtactggct
    22201 actgacatat ataaacaagt agttggacaa tttaacatac caatgggagc tactgtttct
    22261 atggtaatgt taattcctgt actaatagca tttacattag ataagatggc aagtaagaaa
    22321 caaggtatga ccataactgc aaagtctatg ccatataaga ttaaggaaaa taagtttaga
    22381 gatagagtat ttttaatagt atgtagtttt ataacattgc taatttttat tttaatattc
    22441 gtttcagtta taggttcagt tataaagtta tggccatata atttaagctt tacaatggaa
    22501 cactatacat ttaaaggtat tttgggaagt ggaataaaaa catatttaag cagtttgaaa
    22561 atatcaactt taacagcaat atttggaact atatttgtat tttttagtgc ttatatgata
    22621 gaaaaggtgg ataagtttcc taaattaaga caaacagctt accttttatc aatgatacca
    22681 atggccttac ctggcttagt tttaggtata tcatatataa ctttttttaa ctcagcaagt
    22741 aatccattaa attttttata tggaagtaca gcaatattag ttatagtaaa tgtagttcat
    22801 ttttattcag tttgttttat aacctcaaat tcatctttaa aaatgttgga taaagagtat
    22861 gaattagttg caaaatccat aaatattcca ttctataaag tattttttaa tataacagtt
    22921 ccaatgtcta taacatcaat acttgaaata gtagtatatt attttgtaaa ttcaatggtt
    22981 actgtttcag cattaatatt tttatataca cctcaaactc agactgcatc aatatcaata
    23041 ctaaagttag atgagatagg atatatagga ccatcagctg ctatggcagt attagtgctt
    23101 ttaacaaata taatagtaag acttttgtac gaatttgtaa caaagaaatt aaaaaataac
    23161 acacaaaaat ggcagcaaaa agatgttgca taggggaggt aaaaatgaaa tttaagaagc
    23221 tagtttcttt aggagtatta tcaacacttt tattaagtgt aataacagga tgtagtactg
    23281 attcatcagg ttcagattca aagtctgata gtaagacaaa aggggattta acagtttaca
    23341 cagcaattga agaagatagt atagagccat atttagctac atttaaagag aaatatccag
    23401 atattaaatt aaatattgtt agggcatcaa caggagatat aacagcaaga ttattagcag
    23461 aaaaggataa tcctcaagca gatgttgtat ggggagttgc agccacaagc ttattggttg
    23521 cagatgacca ggggatgtta gaaccatatg ctccaaaagg ttctgaagaa atagagtctg
    23581 catttaaaga tgataaagaa gttccttctt gggttgggat agatgcttgg atgacaggta
    23641 taacagtaaa cactaaagaa ttaagtgata agaacatccc agttcctagt tcttacgaag
    23701 attcaataaa gccagaatat aaaggtctta tatctatgcc taatccatct tcttctggta
    23761 cagggtactt aacagtatca gcccttatac aaattatggg ggaagaaaaa gcatggcagt
    23821 atatggataa gttacatgag aatattggtg tatacactca atctggttca gctccagcta
    23881 catcagcagc ttcaggagaa tatcctattg gtatatcttt tggatataga ggtataaagt
    23941 taaaagagga aggctatcca gtagaagtag tatttccaaa agaaggttct ggatgggata
    24001 tagaagcaaa tgctcttgtg aaaaaagata atataaaaga agcatcaaaa gtatttttag
    24061 attgggctat aagtaaagat gcaatgaacg aatactctaa aaactatgca gttactacta
    24121 tttctacagg aaatccaata ccagaaggat tccctaaaaa gccattagag caaatgatag
    24181 ataatgattt aaaatcagca gcaaaaaata gagaagatat actaaataaa tggatatcaa
    24241 aatatgatgg taagacagaa aaagagagtt aagtaaaact atacaaatgg agtaaaaaga
    24301 aaaatttttt ttaagtagat tttattatta taatataagt tgagaataat ataggtcaag
    24361 aaaagtgaat attctataaa aatgtataga gtaagtatac cattcagttt gaatggtata
    24421 ttttttattt ttagagatta atttagaaat agatatacta cagtttaaaa tagtata
//
LOCUS       DAEHWM010000059        24459 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.060, whole genome shotgun sequence.
ACCESSION   DAEHWM010000059 DAEHWM010000000
VERSION     DAEHWM010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24459)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24459)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24459
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.060"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(123..872)
                     /locus_tag="KNP36_002375"
     CDS             complement(123..872)
                     /locus_tag="KNP36_002375"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HBF0874240.1"
                     /translation="MLKVIATGYDGKMGKILADTIREDNELELVCVAARGLDSYEGDL
                     KIYEDMSTIVEEADVVIDFSHHSNLDNILSYVLKTKTPLVIATTGYNDDEMNKIREAA
                     KVIPVFQSYNMSLGVNVLVKLVKDAAKLLEGFDIEIIEKHHNRKVDAPSGTAVMIANA
                     IKEVLPNVENNYGRYGRSAKRQPNEVGIHAIRGGNIVGEHDALFAGDNEVLTISHQAQ
                     SRGIFASGSIAAAKYLVKQKPGFYNMDSMLG"
     gene            complement(939..1826)
                     /locus_tag="KNP36_002376"
     CDS             complement(939..1826)
                     /locus_tag="KNP36_002376"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBF0874241.1"
                     /translation="MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCG
                     TTGEANTMTDEEQLATIKYVVEKVNKRVPVIAGSGSNDTMHSVNLSQEAEKLGVDALL
                     IITPYYNKANKAGLKRHFETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVA
                     VKEASGDLGQVAEIASLVPDDFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDL
                     VAKFFEGDIEGSRKLQLGMDALIAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDP
                     ANLEVLKKELVNFGLKVNA"
     gene            complement(1943..2944)
                     /locus_tag="KNP36_002377"
     CDS             complement(1943..2944)
                     /locus_tag="KNP36_002377"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HBF0874242.1"
                     /translation="MKKVNVAIVGATGMVGRTFLKVLEERNFPIENLFLFSSSKSAGS
                     KVMFCGKEYIVEELKETSFTDRGIQIALFSAGGSISEKYAPIAASNGILVVDNSSQWR
                     MNPDVPLVVPEVNPEAIKNHKGIIANPNCSTIQAMVPLKALDDKYKIKRVVYSTYQAV
                     SGSGVKGVEDLEKGMNGNPTGFYPHQISYNCLPHIDSFTENGYTKEEMKMVNETMKIL
                     DNYDLKITATTVRVPVKNGHSESINVEFNNPFELDDLVKTLEEAPGVVVVDNPAKNEY
                     PTAVEFDDRDEVFVGRIRRDFSVDNGVNLWVVADNIRKGAATNAIQIAEMALSYDLV"
     gene            complement(3369..4250)
                     /locus_tag="KNP36_002378"
     CDS             complement(3369..4250)
                     /locus_tag="KNP36_002378"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HBF0874243.1"
                     /translation="MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCG
                     TTGEATTMSESEIFAVIKYTVEKVNKRIPVIAGTGSNNTMLSVHMSQEAEKLGVDGLL
                     IITPYYNKTNEKGLKLHFETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVA
                     VKEASGDLAQVAEIAKLVPKDFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDL
                     VTKFFEGDIEGSKKLQLDMDALIAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEE
                     TNLNVLKQELTNFGFKF"
     gene            4573..5766
                     /locus_tag="KNP36_002379"
     CDS             4573..5766
                     /locus_tag="KNP36_002379"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase"
                     /protein_id="HBF0874244.1"
                     /translation="MDTLKELFKIGSGPSSSHTMGPQRAAERFKNENPDAESFRAILY
                     GSLAATGKGHLTDYIIEKTIAPKKVEIVWEEDIIKDFHPNGMKFEALDKDKNVTAEWT
                     VYSVGGGTIAEEGQRNSKSNSIYHLDTMDEIVKWCKENNKTLVDFVLECEPKDIKDYI
                     KTIKDAMRKSIDDGLSTDEIIPGKLLLKRRASTFYNAYKKDKSFSTLVYAYALAASEQ
                     NASGNIIVTAPTCGSAGVIPGIFFAMQDFYNYDDEKIIEALLVAGIIGNIIKTNASIS
                     GAEVGCQGEVGAACSMAAAAVAYLKGGTIDHIEYAAEIALEHHLGMTCDPVYGYVQIP
                     CIERNAMAAQRAYDAANYALLTDGSHSVSLDQVVETMKETGIDMMDKYKETAKGGLAK
                     HFFSC"
     gene            5972..7090
                     /locus_tag="KNP36_002380"
     CDS             5972..7090
                     /locus_tag="KNP36_002380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438795.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HBF0874245.1"
                     /translation="MREASYLQEQLYKHRKSLNPIAEIGRKEYKTSKYIRDYLDKLGI
                     EYEVYLETGIVGVIEGKRPKKDIAFRADIDGLHSEEGVKHLCGHDGHATILLGLIEYL
                     NDNKEDLNDNIVFIFQPAEEGPGGAKALIDEGVLRKYNIDEIYGLHIYPELPEGYVGT
                     REGYFMAQIGDIDIEIVSKSGHGAMPQNGIDGIVIASNFVSSLQTIVSRNISPIDNAV
                     LTIGRIEGGARRNIIAENIKMEGTMRCFSPEVYEKMKLRVRELARGFELAYNCKVNIN
                     IIDDYIAVKNDKDLYQEFVEAIGSDTVVELEPLMISEDFSYYQKEVPGLFFMLGSRNE
                     EKGFVNGLHNINFNFDEKICVNALNVYSKLLKYKEAID"
     gene            7221..7466
                     /locus_tag="KNP36_002381"
     CDS             7221..7466
                     /locus_tag="KNP36_002381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small, acid-soluble spore protein, alpha/beta
                     type"
                     /protein_id="HBF0874246.1"
                     /translation="MKEKVQREKKITNGKNTKILTNDDIMKYEIASELGLMDKVGERG
                     WAGLTAKEAGRIGGMLTSRKKRLKKIVEEQNKKDESI"
     gene            7453..8199
                     /locus_tag="KNP36_002382"
     CDS             7453..8199
                     /locus_tag="KNP36_002382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBF0874247.1"
                     /translation="MSQYSDFAFVYDELMNEVDYNGWVKYIEDIIDSEGVKVKNILEL
                     ACGTGNLTIPLTKKNYDIAGIDISDEMLSVAREKAEKEGVELVLLQQDISELDFEISD
                     LDCVLCACDGFNYITYDDDLENVFSKTYELLKKDGIFIFDISSFYKLANILGNNMYGE
                     NREDIAYMWQNYFDEEENLIEMELTFFIKDECGKFERFEEIHQQRAYTEDEIVDMLEK
                     SGFKDIKYYGDFTFDKPSEESQRIFFVCKK"
     gene            8484..9359
                     /gene="hslO"
                     /locus_tag="KNP36_002383"
     CDS             8484..9359
                     /gene="hslO"
                     /locus_tag="KNP36_002383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HBF0874248.1"
                     /translation="MRDYVLRATSGNGQVRAFVATTRNTVEEARRLHETTKVATAALG
                     RTLTATSIMGLMMKNDSDKLTVIIKGGGPIGTIIATSDSKGMVKGYVGNPQVEVEDYP
                     NGKLNVAAAVGTEGVVKVIKDLGLREPYNGTYPLVSGEIAEDFTYYFAVSEQTPSVVA
                     LGVLTKEDEVEFAGGFIVQLMPDAEEETIAKLEENVAKLPSITNMLKEGKSPEDILNI
                     VLDGLEPKILDTCEVGFMCECSKERVKTALVAIGKKSLAQIIEEDKKAEVGCQFCNKK
                     YMYSEEELLEILKEM"
     gene            9750..10550
                     /locus_tag="KNP36_002384"
     CDS             9750..10550
                     /locus_tag="KNP36_002384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBF0874249.1"
                     /translation="MESKTKYIGISILILLMIFLIAKNFNGKLEIPIPESNSRKFKSA
                     AVFYPQHQDDEVLWGGSAIVDAIKQCGVDNVYVVLVSDGSGVNVFKANTKFRNLTRKQ
                     KEELRNNEFKSALRELGVKPQNVIILADIDKKEGTHYELMEKTILDFEHKFKGNVTHI
                     AHHYKYDDHIMHRKNGEVLKKLKREGKIKDDLYFVKPKYVKYIPRNERAIYKAMDFDD
                     YNKVKSACYEYKVVNSKRKMYGIGYISAHSYFEHLLNDPELTSVLSED"
     gene            11078..13318
                     /locus_tag="KNP36_002385"
     CDS             11078..13318
                     /locus_tag="KNP36_002385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBF0874250.1"
                     /translation="MNNEFIILKGCKENNLNNISLKIPKRKITIFTGVSGSGKSSIVF
                     ETIAKESQRQLNERFSTFVRSFLPKYGEVKADCIENLSTPIIIDQSRLGGNSRSTLGT
                     ITDVNSFLRALYSRFGSEYIGNANMFSFNNIDGMCPHCHGLGKKLVPNMNQILDMNKS
                     LNEGAILLSGFGVGSWHWNIFAESGFFDINKRICDYSEVELEKFLHGKAEKIKIENAG
                     QTNMTYEGLMVKFNRLYLSREGEISEATKKKLSKLLIEDRCPICDGRRLNERVYRSLI
                     NGYNIADLTSMQIDELAEVIKSIDEPEAQPLIKGIIEKLNSIIDIGLGYLTLDRETSS
                     LSGGESQRIKMVKYLNSNLVDLMYIFDEPSVGLHPKDVYKLNNLLKKLRDKGNTIIVV
                     EHDPDVIKIADHIVDVGPKAGKYGGEVVYEGSYENLLTSGTLTGNALSKFLPIKESVR
                     EHSGYLEVKNCNKNNLKNVSIKIPKGVLTLVTGVAGAGKSTLIKDEFLKQNPSAVLID
                     QSPVSANSRSSLATYSGIMNNIRSIFSKTNGVNASLFSSNSEGACDNCKGSGIVEMNL
                     AFMESIKSTCNICEGKKFKKEVLEYRFQGKNIIEVLEMSVLEAIEFFNLKQIKTKLQC
                     IEKMGIGYLTLGQTLDTLSGGECQRLKLASELNKESSVYILDEPTTGLHMADIENFIS
                     IIEEIVDNGNTVIIIEHNIDVIKRADWIIELGPEGGTKGGRVIFEGIPKQLCNNKISL
                     TAKYIV"
     gene            13732..15267
                     /locus_tag="KNP36_002386"
     CDS             13732..15267
                     /locus_tag="KNP36_002386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBF0874251.1"
                     /translation="MINDILTLLSERSDFFIKLSIEHLMISIISIIIAIVLGGIIGII
                     VSEFHNSSKPILGTINFLYTIPSISMLGFLIPFSGIGNTTAVIALTIYALLPMVRNTY
                     TGITNVDKNILEAARGMGSTDFQILYKIKLPLALPVIMSGIRNMVIMTIALAGIASFI
                     GAGGLGVAIYRGITTNNTIMTITGSILIALLALIFDFILGLVEKFFQRKRKKKNRKKV
                     FAILGSLILIVIIFTSYLFNPSKTQTIHIATKPMTEQYILGEMLDILIEKNTGLNVEI
                     TQGVGGGTSNIQPAMENGEFDIYPEYTGTGWNMVLKKNELYTESMFSKLQSEYKTKLK
                     MQWTGMYGFSNSYALAVRKEVADKYNLKNITDLKDVSSKLTFGAEYDFYEREDGYTPL
                     CNTYGLNFKDTVDLDIGLKYQAINEGKIDVMPIFTTDGQYSVSDVVVLKDDKNFYPSY
                     QCGNVVRLEVLEENPELSKVFKMVGDILTDKEMAKMNYDVENNNLEPREVAREFLNKK
                     GLL"
     gene            15283..16044
                     /locus_tag="KNP36_002387"
     CDS             15283..16044
                     /locus_tag="KNP36_002387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874252.1"
                     /translation="MTPIIQFKNIKKQYNDKTIIDNLNLDIEKGEFLTVIGSSGSGKT
                     TLLKMINGLILPDGGNILINQTDIKNEDLIKLRRRIGYCVQGSVLFPHMTVEENISYV
                     PNLLSKKNKLEVKSAVNKWMEIVGLPNDMKVRYPSELSGGQQQRVGIARALASSPEIL
                     LMDEPFGAVDEITRKQLQKEIKEIHKKTGVTIIFITHDIYEALILGTKTLVLNHGVVQ
                     QYDTPENILNTPANQFVDQLLNIRKSIIDDDNLKE"
     gene            16382..17251
                     /locus_tag="KNP36_002388"
     CDS             16382..17251
                     /locus_tag="KNP36_002388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0874253.1"
                     /translation="MDNNLITIEKTLDYIEKHLLDEMLDLNVISKEIGYSKYHLHRMF
                     TSVVGFSVHNYIQRRRLTEAARMLIFTEKPIIEIALISGYDTQRSFSRGFKKMFKRSP
                     NFFRRHQDFLPLQLKFDIHNRKKLRGDMVLDVKKVNCADINIVGYSGKVRKGFHIIGK
                     CWRDLHKNKEMIENKVDLGFLIGVSDYSNFKEIENTPTFTYIAGAQVATFGKLPNGME
                     KFVLPKSNYIVFTFIGKNEDSMQNVVEYIYQEWFPNSSCQFNENNLYDFVKYGEKTDE
                     NGLSEIQFWVPII"
     gene            17580..17831
                     /locus_tag="KNP36_002389"
     CDS             17580..17831
                     /locus_tag="KNP36_002389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3781 domain-containing protein"
                     /protein_id="HBF0874254.1"
                     /translation="MNVENELLKNLDRLHTTELGVVRIKKNLSLETNDVVNWCKTKIE
                     SPNAIINRKGKNWYISVYDCIITVNAHSYTIITAHKEKK"
     gene            17943..18722
                     /locus_tag="KNP36_002390"
     CDS             17943..18722
                     /locus_tag="KNP36_002390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBF0874255.1"
                     /translation="MNDTVKEKLAESLTSDTTDILPYLPYLLQDFWELGSSPEQMLQL
                     FRKHIPFNEDTKVLDLACGKGAVSVKLAKELNIHIKGIDLIPEFINYARRKAIEYKVD
                     ALCDFEMNDANSSVKIEHDYDCVIFGAVGDILGNYKETISKLLPTIKSKGFILIDDAY
                     VVDKSTNEQLNFERVYPTYNEWCILFKELGLKLIECIPCLELENDVEEEMNWIITRAN
                     ELIKKYPSQKDMFEQYVISQKNEYTDLQQDLVGATWILQKE"
     gene            complement(18857..19507)
                     /locus_tag="KNP36_002391"
     CDS             complement(18857..19507)
                     /locus_tag="KNP36_002391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874256.1"
                     /translation="MNIVMINGSPKVNKNNSQYFLSELKQLIQNDNKVFTFKVDSTSK
                     YPDALNAILNCDRLIIASPLYVDGIPSHLLHFLEKCEKFLKTQNKKPIPVYAIVNCGF
                     NEGEHNHLAIQMIEHWCKKINFTWVQGIGIGAGEMFGSLESVPLGKGPKKDLGIALKE
                     LSKNILSDNIHIDDSNKSTIFISPNFPRFLYKLMGNHQWNTQAKSNGLTKSDILKK"
     gene            complement(19504..20007)
                     /locus_tag="KNP36_002392"
     CDS             complement(19504..20007)
                     /locus_tag="KNP36_002392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0874257.1"
                     /translation="MRLLIHDLTDKELEKLLPKLDDNIKILPNTKEIHKCIGCFGCWI
                     KTPSECVVKDYYSNMGKLINDSDGIIIISRCCYGGFSPFVKNVLDKSINYILPYFVIK
                     DNMMRHKSRYDKQINLKAIFYGDCITEAEKETATKLVNGNAINFNIKEHSVCFYENIQ
                     DIRGESI"
     gene            complement(20056..20571)
                     /locus_tag="KNP36_002393"
     CDS             complement(20056..20571)
                     /locus_tag="KNP36_002393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBF0874258.1"
                     /translation="MLEYIILGFLMEKELSGYDLKQIMSESTSYFFDASFGSIYPALK
                     RLETKGYIHYHEVIDGSKLKKLYSITNTGKEVFLEWLKKPINFSKTKQDHLVNIFFYK
                     YLPKEIIETNLKMLITEVELLLNKLSKQKNDAEENHCVDQYTYMYATMIYGVDYYNFV
                     INWCKDLLKNL"
     gene            20851..21378
                     /locus_tag="KNP36_002394"
     CDS             20851..21378
                     /locus_tag="KNP36_002394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0874259.1"
                     /translation="MHEQIDYCERKKIRTIDIKGENMRELLKWVSIINRYNTNYIDRK
                     LADIGINNSQYFYVLHICNNPGITQDTIFEKILVNPSNITRALANLEKEGFITREPGV
                     KDKRTWHLYPTEKSLGCYDEILKITNGYVEELLSSFEKEEQELFMSMLKKVAFLAIDM
                     NEEAKLEAKENGRKI"
     gene            21362..22765
                     /locus_tag="KNP36_002395"
     CDS             21362..22765
                     /locus_tag="KNP36_002395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0874260.1"
                     /translation="MEEKYKEPLEYEKVSKLLTKYAIPSIIAMLVSALYNIVDQIFIG
                     QGVGVLGNAATNVTFPLTTICTAIALLLGIGGASKCSLELGAKNSEKATKAAGNSICL
                     MAVFGISLFIVVSIFLTPLLKFFGSTSEILPYAHTYTKITSIGLPFLIMSTGMSKLIL
                     ADGRPKASMFCMLIGAVINTILNPLFIFVFNMGIAGSALATVIGQLISFGISVHYIKN
                     FQHIKLHKKSFKLDSIIYKHIFALGSSSCFNQLAMTVTQIVMNNTLAYYGARSVYGSE
                     IPLACVGIIIKVNMIFISIIIGISQGMQPIIGYNYGAEKYNRVKEAYKFAVGSATIIS
                     VIAFLCFQFFPRQITSIFGNGNETYFIFAEHYFRTFLFLTFINGVQIVSSTFFTSIGK
                     SVLGLFTSLTRQILFLIPLIVILPMFMGIDGVMFAGPIADAAAAMVCIYFAVHEMKSL
                     TIKQNNLMSNHNKIAEV"
     gene            complement(23148..23459)
                     /locus_tag="KNP36_002396"
     CDS             complement(23148..23459)
                     /locus_tag="KNP36_002396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874261.1"
                     /translation="MKKIIKSFTSWFFLIALFEIYMHQIGQDSKSIVLIGLNPILSII
                     SRVDSFFVFMDSGMQIPCRTITGSISIYWYIASILSFLIYGIILDLIRIVISKIGNKT
                     K"
     gene            complement(23515..24108)
                     /locus_tag="KNP36_002397"
     CDS             complement(23515..24108)
                     /locus_tag="KNP36_002397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0874262.1"
                     /translation="MISDSISKRRSIRKYKNQSISHETIEKIIEAGINAPSSKNRQPW
                     RFVVITEKEKESMLKAMSKGIQNEINDNGLLPGSRQHIAGANYTVEIMKQAPVTIFIL
                     NILGKSPLEKLSPEERFYEMANMQSIGAAIQNMSLTAVELGLGSLWICDVYFAYRELC
                     EWLNTDSQLVAAISLGYPDEEPSRRPRLQLSDVTEWR"
BASE COUNT         9094 a         2956 c         4084 g         8325 t
ORIGIN      
        1 agtttttatt gtatagacat agtattaaat aaatttatta tatatgtttg atttgtattg
       61 cgtattatta tatctatatt gcatatgttt aatttatatt gtgtattatt atatttatgc
      121 tattatccca acatgctgtc catattataa aatcctggtt tttgcttaac taagtatttg
      181 gcagcagcta tagaaccact tgcaaagata ccacgagatt gagcttgatg gcttattgta
      241 agaacctcat tgtctccagc aaatagagca tcatgttcgc caacaatatt tccacctctt
      301 atagcatgaa taccaacttc atttggttgt ctttttgcac tacgaccata tctaccataa
      361 ttattttcaa cgtttggcaa aacctctttt atagcgttag caatcataac agctgtgcca
      421 cttggggcat ctacttttct gttgtgatgt ttttctatta tttctatatc aaatccttct
      481 agtaatttag ctgcatcttt aaccaatttt actaatacat ttacaccaag agacatatta
      541 tatgattgga atacaggaat aactttagcc gcttcacgta ttttgttcat ttcgtcatca
      601 ttatatccag tagtagcaat tactaaaggt gttttagtct ttaaaacgta agataagata
      661 ttatctaaat tagagtgatg agaaaaatct ataactacat cagcttcctc aactatagta
      721 ctcatatctt cataaatttt aaggtcgcct tcatagctat ccagacctct agctgcaaca
      781 caaaccaatt ctaattcatt atcttctctt atagtatcgg ctaaaatctt acccattttt
      841 ccatcataac cagttgctat aacttttaac ataatttcct cctatgatta agggctaact
      901 tttgaccaaa cttacttttt accatgcatt aatctttact atgcattaac ttttagccca
      961 aagttaacta attctttctt taatacttct aaatttgctg ggtccatttc tgctagaggt
     1021 aatcttaaat ctccaacatt gaatcccaat aaattcattg cagtcttaac tggtatagga
     1081 tttacttcta taaataaagc tgcgattaga gcatccatac caagttgtaa ttttctagaa
     1141 ccttcaatat cgccttcaaa gaatttagct accaaatcgt gagtttcttg agggcaaaca
     1201 ttagcaagta ctgatataac tccttgacct cctaaagata ataaaggaag tatagtatca
     1261 tcattaccag agtagatagc aaagtcatct ggaactaaac tagctatttc tgcaacctgt
     1321 cctaggtctc cactagcttc ttttacagca actatgttat caattttagc aagttcaact
     1381 ataaggctag gacttatatt tacacaagtt cttccaggga cattgtaaag tataattgga
     1441 agtttaacac tgttagctat tgtttcaaaa tgacgcttaa gtccagcttt attagcttta
     1501 ttgtaataag gtgttattat taatagagca tctactccta atttttcagc ttcttgactt
     1561 aagttaactg agtgcatagt atcattagaa ccacttccag ctataacagg aactctttta
     1621 ttaacttttt caacaacata cttaatagta gcaagttgtt cttcatcagt catagtatta
     1681 gcttcaccag tagtaccaca agatactata gcatcagtac cattagctat ttggtattca
     1741 actaattcac ctaatttgtc aaaatcaact ttgttatcct ttgtaaatgg tgtaactaga
     1801 gcaacagcag aacctttaaa tatcatataa aatcaatccc ctctttttta tttttgtgtt
     1861 ttatattaca gttacttcta atgcttgttt ttgagttact attaatattt tacaaaatta
     1921 tatatttata caagtttgta tattatacta aatcgtatga taaagccatt tcagctattt
     1981 gaattgcgtt agttgcagca ccttttctta tattatcagc aacaacccaa agatttacac
     2041 cattatcaac actaaaatct cttcttattc ttccaacaaa cacttcatct ctatcatcaa
     2101 attctacagc agttggatat tcgtttttag caggattatc aactactaca acacctggag
     2161 cttcttcaag tgtttttact aaatcatcta actcaaatgg attgttaaac tcaacattta
     2221 tagattcact atgaccattt tttactggaa ctcttacagt agttgcagtt atttttaaat
     2281 cgtagttatc aagtattttc atagtttcat ttaccatttt catttcttct ttagtgtatc
     2341 cattttcagt gaatgaatct atatgaggaa gacagttgta agagatttga tgagggtaga
     2401 atccagtagg attaccgttc attcctttct ctaaatcttc aacaccttta acaccagaac
     2461 cagatacagc ttggtaagta gagtaaacaa ctctcttaat tttgtattta tcatcaagag
     2521 ctttaagggg aaccatagct tgtatagtag agcagttagg attagctatt atacccttat
     2581 gattttttat ggcttctgga ttaacctcag gaactactaa aggcacatct ggattcattc
     2641 tccattgact agagttatct actactaaga ttccatttga agcagctatt ggagcatact
     2701 tttcactaat acttccacca gcagagaata atgctatttg tatgcctcta tcagtaaatg
     2761 aagtttcctt taattcttct actatatatt ctttaccaca aaacattact ttagaaccag
     2821 ctgatttaga agaagagaat aaaaatagat tttctattgg aaaatttctt tcttctaata
     2881 cttttaaaaa tgttctacct accattccag tagcaccaac tattgctaca tttacttttt
     2941 tcatataaat tcaccccaat tttaaattat taaaacatta ttttatttta gttatacaag
     3001 taagatatgt taatattttt atatatccaa aaactttaat attatattaa caactttaat
     3061 tatatacaaa aaacgtacaa aggtatactt tgtacgtcta atttatcact caaagtaaac
     3121 cctgtagctc atcacctaca aaaataagtg acagtattac acatgttatg tgcaatccca
     3181 gaaaatatta ttgcaagaaa tattttcttc ggctgtaaat cctttttcca atcattaaca
     3241 cctgccagct actattggat actcttagtt acagctacct ctaccctagg ttaataggat
     3301 attaaaattt gattattcta ataataatac atatttaaga aaaaatcaac ttatttatat
     3361 aaatattgct aaaatttaaa tccaaaattt gtcaattctt gttttaacac attaagatta
     3421 gtttcttcca tttcagctag aggaagtctt aaatcaccaa cattaaaacc taaaatgttc
     3481 atggcagttt taacaggaac tggatttact tctataaata aagcagcaat taaagcatcc
     3541 atatcaagtt gtaatttttt tgagccttca atatcacctt caaagaattt agttactaaa
     3601 tcatgtgttt ctttaggaca tatgttagca agtacagaga taacaccact tccacctaat
     3661 gataatagtg gtagtatagt atcatcatta ccggagtata tagcaaagtc tttaggtact
     3721 aatttagcta tttctgcaac ttgagctaag tctccacttg cttccttcac agcaactata
     3781 ttatctattt tagcaagttc agccacaaca gatggcttta tattcacttt agttcttcct
     3841 ggtacgttgt ataaaataat tggcaactta acgctatttg ctattgtttc aaagtgaagt
     3901 ttaagacctt tctcattagt cttattatag taaggagtta ttattaaaag accatccacc
     3961 cctaattttt cagcttcttg actcatatga acagacaaca tagtattgtt tgaaccagta
     4021 cctgctataa caggtattct cttattaact ttttcaactg tatattttat tacagcaaaa
     4081 atttcagatt cactcatagt agtcgcctca cctgttgttc cacaaacaac tagtgcatct
     4141 gtgccattct caatgtgata ttcgattaat tcacctaatt tttcaaagtt gacattatta
     4201 tcctctgtaa atggggtaac taaagcaaca gcagaacctt taaataacat ataatcaaat
     4261 ctcctttttt atctaaattt aattttttaa gtacaataat aattatagta caaattaatt
     4321 aattttaata ggtatagtta atatcttaac tgtttaaata agatatttat attatattaa
     4381 tattagaaaa attttaaata aatgttttat tctcaaaata tgcatattaa tttaataaaa
     4441 tataccaaaa tggaaataaa aaataaattt tatgagaatt taataactaa taattaatat
     4501 atttaggtta taataaatat gtgcgtaaaa tctaacaata agcaataata ccgtaaattt
     4561 aggaggaata atatggatac tttaaaggaa ctttttaaaa taggaagtgg accttcaagt
     4621 tctcatacta tgggaccaca aagagcagca gagagattta agaatgaaaa cccagatgca
     4681 gaaagtttta gagcaatatt atatggtagt ttggcagcta cagggaaagg tcacttaact
     4741 gactatataa ttgaaaaaac tatagcacct aaaaaagtcg aaattgtttg ggaagaagat
     4801 attataaaag attttcaccc aaatgggatg aagtttgaag ctttagataa agataaaaat
     4861 gtaacagctg aatggactgt atattctgta ggtggaggga ctatagcaga agaaggtcaa
     4921 agaaacagta aaagcaatag tatatatcac ttagatacta tggatgagat agtaaaatgg
     4981 tgcaaagaaa ataataagac tttggtagat tttgtgttgg aatgtgaacc aaaagacata
     5041 aaagattata taaaaactat aaaagatgct atgagaaaat ctattgatga tggactaagt
     5101 acagatgaaa taataccagg caagttatta ttaaaaagaa gagcaagtac attttataat
     5161 gcatataaaa aagataagag cttctcaaca cttgtatatg catatgcact agcagcttca
     5221 gagcaaaacg cttctggtaa tataatagtt acagcaccaa cttgtggttc tgctggagta
     5281 ataccaggaa tattctttgc aatgcaggat ttctataatt atgatgacga aaaaataatt
     5341 gaagcactac ttgtagctgg aataataggt aatataataa aaactaacgc ttcaatatct
     5401 ggagcagagg tagggtgtca aggtgaagtt ggagccgctt gttctatggc agcagcagca
     5461 gtagcatact taaaaggtgg aactatagac catattgaat atgcggcaga aatagcactt
     5521 gaacatcatt taggaatgac ttgtgaccct gtatatggat atgttcaaat tccatgtata
     5581 gaaagaaatg caatggcagc tcaaagagct tatgatgcag ctaattatgc attattaact
     5641 gatggctcac attctgtctc cttagaccaa gttgttgaaa caatgaaaga aactggtata
     5701 gatatgatgg ataagtacaa agaaacagct aagggtggac ttgctaaaca tttcttctct
     5761 tgctaaaaat aaaattttcc aataataatt cctctgtttt gatttatgaa acaggggaat
     5821 tattattaat ggtgaattat ttaataatgc aaaatatttt tatattcaat ttagcttttt
     5881 atttttaatt agtataacat gctatataat attttaatta taaagaaata tagaaatatt
     5941 ttttaataaa ttagaaattg gaggagatta catgagagag gcatcatatt tacaagaaca
     6001 actttataaa cataggaagt cattaaatcc tattgcagag attgggagaa aagagtataa
     6061 gacttcaaaa tatataagag attatcttga taaattagga attgagtatg aagtttattt
     6121 agaaacaggt atagtaggtg taatagaagg taaaagacct aaaaaagata ttgcttttag
     6181 agctgacata gatggtcttc atagtgaaga aggggtaaaa catttatgtg gtcatgatgg
     6241 acatgctact atattacttg gattaattga gtatttaaat gataataaag aagacttaaa
     6301 tgataatata gtatttatat tccaaccagc agaagaaggt cctgggggag caaaagcttt
     6361 aatagatgaa ggagtgctta gaaaatacaa tattgatgaa atatatgggc ttcatatata
     6421 tccagagtta ccagaaggtt atgtaggtac aagagagggc tattttatgg ctcaaatagg
     6481 agatattgac atagaaatag tgtctaaaag tggacatggg gctatgccac aaaatggtat
     6541 tgatggtata gtgatagctt caaactttgt aagctcactt caaactatag tgtctagaaa
     6601 tataagccca atagacaatg cagtgttgac tattggtaga attgaagggg gagctagaag
     6661 aaatataata gctgaaaata taaagatgga aggtactatg agatgtttca gcccagaagt
     6721 gtatgagaaa atgaagctta gagttagaga acttgctaga gggtttgaat tggcttataa
     6781 ctgtaaggtt aatataaata ttatagatga ttatattgct gttaaaaatg acaaggattt
     6841 gtatcaagag tttgtagagg ctattggaag tgatactgtt gtagagttag agccacttat
     6901 gatatcagaa gatttttctt attatcaaaa agaagttcca ggattatttt ttatgttggg
     6961 ttcaagaaac gaagaaaaag gatttgtaaa tggtcttcat aatataaact ttaattttga
     7021 tgaaaagata tgtgtaaatg cattgaatgt ttattcaaaa ttattaaaat acaaagaagc
     7081 aatagattag gaagataagt tataaagatt aaaaagcata aatacctaaa tttaaaaaaa
     7141 gtgtattaat aaatacccct tacatatttg tataaattta ttttaattga caaaaataca
     7201 aataagaagg ggtgattttt ttgaaagaaa aagtacaaag agaaaagaag ataactaatg
     7261 gcaagaatac taaaatattg acaaatgatg atataatgaa atatgagata gcctcagaac
     7321 taggtcttat ggataaagtt ggtgaacgtg gatgggcagg acttacagct aaggaagcag
     7381 gaagaattgg aggtatgctt acatcacgca aaaagaggct taaaaagatt gtggaggagc
     7441 agaataaaaa ggatgagtca atatagtgat tttgcgtttg tatatgatga acttatgaat
     7501 gaagttgatt ataatggttg ggttaaatat atagaagata taatagatag tgaaggtgta
     7561 aaagtaaaaa atatattgga attggcatgt ggcacgggta atcttacaat tccattgact
     7621 aaaaaaaatt acgatatagc tggtatagat atatctgatg agatgcttag tgtagcaaga
     7681 gaaaaggcag aaaaagaagg agtagaatta gttttacttc aacaagatat atcagagctt
     7741 gattttgaaa tatctgattt ggactgtgta ctttgtgctt gtgatggatt taattatata
     7801 acttatgatg atgatttgga aaatgtattt tcaaagacat atgaattatt aaagaaagat
     7861 ggaatattca tatttgatat aagttctttt tataaattag ccaacatatt gggaaataac
     7921 atgtatggag aaaatagaga agatatagcg tatatgtggc aaaattactt tgatgaagaa
     7981 gagaatctaa ttgaaatgga acttacattc tttattaaag atgaatgtgg aaagtttgaa
     8041 agatttgaag agatacacca acaaagagca tatactgaag atgagatagt tgatatgctt
     8101 gaaaaatctg gatttaagga tataaaatat tatggggatt ttacatttga caaacctagt
     8161 gaagaaagtc aaagaatctt ctttgtatgt aaaaaataag atattcttga ctatataaga
     8221 taattattaa aaataaccat gatataaaaa tatataaaat gcagttttat agattaaaag
     8281 taaagtgatg atattttatg atttttattt tctaataatt ataaagtttt atagataaaa
     8341 attaaaatat aataactatt gcttagtaaa attaaaataa aatgggtttt gcccaaggtt
     8401 aagatagata agtatttata gattaaaatt aaggtagtaa tataataaaa ataagacaat
     8461 taacgggaca tggaggaata ttaatgagag attatgtact aagagcgaca tcaggaaatg
     8521 gtcaagttag agcatttgtc gcaactacta gaaatacagt agaagaagct agaagattac
     8581 atgaaactac aaaagtagca acagcagcac ttggaagaac attaacagcc acatctataa
     8641 tgggattaat gatgaaaaat gatagtgata aattgactgt aataataaaa ggtggaggtc
     8701 caattggaac tattatcgcc acatcagact ctaagggaat ggtaaaagga tatgtaggaa
     8761 atccacaagt agaggttgaa gactatccaa atggaaagtt aaatgtagca gcagcagtag
     8821 gtacagaagg tgttgtaaaa gttataaaag acttaggtct tagagaacca tataatggga
     8881 cttatccatt ggtaagtgga gaaattgcag aagactttac ttattatttt gctgtatcag
     8941 agcagactcc atcagtagta gctttaggtg ttcttacaaa agaagatgaa gtagagtttg
     9001 ctggaggatt tatagttcaa ttaatgccag atgcagaaga agagactatt gctaagttag
     9061 aggaaaatgt agctaaatta ccttctataa ctaacatgtt aaaagaagga aaatcaccag
     9121 aggatatatt aaatattgtt ttggatggtt tggaacctaa aatacttgat acctgtgaag
     9181 ttgggtttat gtgtgaatgt tcaaaagaaa gagtaaaaac tgctttggtt gcaattggta
     9241 aaaaatcatt ggctcaaata atagaagaag ataaaaaagc agaagttggt tgccagttct
     9301 gtaataagaa gtatatgtat agtgaagaag agttgcttga aattttaaag gaaatgtaga
     9361 ctataaaaat agttgtattg atataagtaa tgttatagta atatagtaaa gtcgtattga
     9421 tatagtaatt aaagtataat ttattaataa tagacatatt tatattaaaa aataagttta
     9481 ataaattttt aagcttaata aattttaaga attaagaagc tttctggctg taatgtttgc
     9541 aatgttgcag ttagaaggct tttttatttt attatagttc gtgtcaaaga ttgtatgaaa
     9601 caataaaata ttgtaaaata atttgtatat ttagacctga ttgacacaaa ggtttataag
     9661 atatttgagt tgattatacg aaattctatg aagtagtaac cctgtgactt taatcatggg
     9721 aggttcagaa gaaggagaaa attttaaata tggaaagtaa aacgaagtac ataggaataa
     9781 gtatattaat attattgatg atatttttaa ttgcaaagaa ttttaacgga aaacttgaaa
     9841 tacctattcc tgagagtaat agtagaaaat ttaaatcagc agcagtgttt tatcctcaac
     9901 atcaagatga tgaggtttta tggggaggaa gtgccattgt agatgctata aaacagtgtg
     9961 gtgttgataa tgtatatgtg gtattagtat cagatggttc tggagttaac gttttcaaag
    10021 ctaacacaaa atttagaaat ttaactagga agcaaaagga agaacttaga aataacgagt
    10081 ttaaatcagc tttgagagag cttggagtga aacctcaaaa tgtgattata cttgcagata
    10141 tagataaaaa ggaaggcaca cattatgaat taatggaaaa gactatattg gattttgaac
    10201 ataagtttaa aggcaatgtg acccatatag cccatcacta taagtatgat gaccatataa
    10261 tgcatagaaa gaatggggaa gttttaaaga aacttaaacg tgaaggtaag ataaaagatg
    10321 acttgtattt tgttaagcca aaatatgtaa agtatatacc aagaaatgaa agagctatct
    10381 ataaagcaat ggattttgat gactacaata aggttaagag tgcttgttat gaatataagg
    10441 ttgtaaattc aaagcgtaaa atgtatggta taggatatat ttcggcacat agttattttg
    10501 aacatcttct aaatgaccct gaacttacgt ctgtattaag tgaagattaa tttcttataa
    10561 gtagtaagtt atgtttgata agttgattgg aattttctat agttttgaag gtattggaaa
    10621 tttagtttta tttaaagatt taaagataga ggtttttagt gtttaaaatt ttaaagttaa
    10681 gttgaataat tgtatagaat tatttgtgaa agaagaaaca gtgtaaaaca tagtatctta
    10741 tttatggttt taaaatcata ggcaagatac tttttttatg taactaatac cattttgaga
    10801 ttattaactt aagaatttta tataatttaa cactcatata taatgatgat atttaggtag
    10861 aatagatgta attacgctta aataaaataa ctgtattttt tataaaaatc caaaccctac
    10921 actatactac cagataaaat ctacatgcta taatttgacc tgtgtttata aaaaaaggag
    10981 taatctaata aaatagtatt tcacttatgt ataactaaca actattatta cgattttctc
    11041 taaataattt aaagaaaaat aatgcaggag gtaaaatatg aacaatgaat ttataatttt
    11101 aaaaggttgc aaagagaaca atttgaacaa tatttcctta aaaataccaa aaagaaaaat
    11161 aaccatattc acaggggtgt cgggttctgg aaagtcatct attgtatttg agacaattgc
    11221 aaaagaatca caacgccaac taaatgaaag gtttagtaca tttgtaagaa gttttttacc
    11281 taagtatgga gaggttaaag ctgattgtat agaaaatttg tcaacaccaa ttatcataga
    11341 ccaaagtaga cttggtggaa attcaaggtc aactctaggt actattacag atgtaaattc
    11401 ctttttaaga gctttatatt caaggtttgg tagtgagtat ataggtaatg ccaatatgtt
    11461 ttcttttaat aatattgatg gtatgtgccc acactgtcat gggcttggaa aaaagctagt
    11521 tcctaatatg aaccaaattc ttgatatgaa taaatcatta aatgaaggtg ctatattgct
    11581 ttcagggttt ggagtgggtt cttggcattg gaatatattc gctgaatcag gattttttga
    11641 tattaataag aggatatgtg attattcaga agtagaattg gaaaagtttt tgcatggtaa
    11701 agcagaaaag attaagatag aaaatgctgg tcaaactaac atgacatatg agggattaat
    11761 ggttaaattt aatcgcctat acttaagtag agagggagaa atatctgaag ctactaagaa
    11821 aaaattgagt aaacttctta tagaagatag atgtcctata tgtgatggaa gaagacttaa
    11881 tgaaagagta tataggtctt taattaatgg ttataatata gcagatttaa ctagtatgca
    11941 aattgatgaa ttggctgaag ttattaaaag tatagatgag ccagaagcac aacctttaat
    12001 taaaggaata atagaaaagt taaacagtat catagatata ggtcttggat atttaacact
    12061 agatagagag acatcttctc tatcaggagg ggaatctcag cgtataaaga tggttaagta
    12121 tttaaatagt aatcttgttg atttaatgta tatttttgat gaaccaagtg taggacttca
    12181 tccaaaagat gtgtataaat taaataatct tttaaaaaaa ttgcgtgata aagggaatac
    12241 aattatagtt gttgaacatg acccagatgt tattaagatt gcagaccata ttgtagatgt
    12301 aggaccaaag gcaggtaagt atggtggaga agttgtgtat gaaggcagtt atgaaaatct
    12361 acttacaagt ggtactttga cagggaatgc tttaagtaaa tttcttccta ttaaagaaag
    12421 tgtaagagaa catagtggat atttagaagt taaaaattgt aataaaaaca atttaaaaaa
    12481 tgtatctatt aagataccta aaggtgtatt gactttagtt actggagtag caggagcagg
    12541 taaaagtaca ttgattaagg atgaattttt aaagcaaaat cctagtgctg tacttataga
    12601 ccaaagccct gtttcagcaa attcaaggtc gagtttggca acatatagtg gaattatgaa
    12661 caacataaga agcatatttt caaaaacaaa tggcgtaaat gcttctttat tcagttcaaa
    12721 ttcagaagga gcttgtgata actgtaaggg ttctggaata gtagaaatga atcttgcttt
    12781 tatggagagt ataaagagta cctgcaatat ttgtgaaggt aaaaaattta aaaaagaagt
    12841 tttagaatat aggtttcaag ggaagaatat aattgaagtt cttgaaatgt ctgttttaga
    12901 ggcaattgag ttttttaatt taaaacagat taaaacgaaa ttacaatgta ttgaaaaaat
    12961 gggtattgga taccttactt taggacaaac tcttgatact ttgtctggag gagagtgtca
    13021 aagattaaag cttgctagtg aattaaataa ggaaagttca gtgtatatat tagatgaacc
    13081 aacaacaggt cttcatatgg ctgatattga gaattttata agtataattg aagagattgt
    13141 agataatgga aatacggtca taataattga acacaatata gatgtaatta aaagagctga
    13201 ttggattatt gagctgggac ctgaaggagg aacaaaaggc gggagagtaa tatttgaagg
    13261 tattccaaaa caattatgta acaataaaat atcattaaca gcaaaatata tagtataata
    13321 aataaaatat aataaaatta taatgatatt ttaataaata taatgggtat ataaaatgat
    13381 aattaaactt aacagtaata aataatgtga gaaatattca aatttaatta aataaagtgt
    13441 cagaaatttg tttaaatttt agtattttaa cggttctgac cttttttctt atttttatgg
    13501 agaatatcga ggatggagtc tctaatagtt acttttttgt gtctacttgc aagtttgatt
    13561 aaaaaatggc tatacacact tgtgacttca gtcatgggag gttcagatta taatcttaat
    13621 atataatttg tgaaataatt tgatgacgat ttgctgatgt ataaacaata aagattaact
    13681 acattaaaat ttaaatcttg ttaagtaaaa cttataaaag gagagagatg gatgataaat
    13741 gatattctaa ccttattatc tgaaagaagt gattttttta taaagctatc catagaacat
    13801 ttgatgattt ctattatttc tataataatt gcgattgttt tgggtggtat aattggtatt
    13861 attgtaagtg aatttcataa ttcttctaaa cctatattgg gaactatcaa ttttctatac
    13921 accattccat ctatttctat gctaggattt ctgataccat tttccggaat tggaaatact
    13981 actgctgtta ttgcacttac catttatgca ttattgccaa tggttagaaa tacatatact
    14041 ggaattacta atgtggataa aaatattctt gaagcagcta ggggaatggg aagtacagat
    14101 tttcagatat tgtataaaat aaaacttccg ttagccctac ctgttattat gtctggtatt
    14161 agaaatatgg tgattatgac aattgcatta gctggtatcg cttcatttat aggtgctgga
    14221 ggcctaggtg tagccatata tagaggaatc acgacaaata acacaataat gacaattact
    14281 ggaagtatac ttattgctct attagcttta atatttgatt ttattttagg gctggtagaa
    14341 aaattttttc aacgaaaaag aaaaaagaaa aataggaaaa aagtttttgc cattctagga
    14401 agccttattc ttatagtaat tatctttacg tcttatttat ttaatccttc aaagactcaa
    14461 actattcata ttgctactaa acctatgact gaacaatata ttcttggtga gatgttggat
    14521 attttaattg aaaaaaacac aggtctaaac gtggaaatta cacaaggtgt aggaggggga
    14581 acatctaata tccagccagc tatggagaat ggagaatttg acatttatcc agagtataca
    14641 ggtacaggct ggaatatggt acttaagaaa aatgaattat atactgaaag tatgtttagt
    14701 aaactacagt cggaatacaa aactaaactt aaaatgcaat ggactggtat gtatggtttt
    14761 tctaatagct atgcattagc agttagaaaa gaagttgcag ataaatacaa tttaaaaaat
    14821 ataacggact taaaagatgt atcttctaaa ttgacatttg gagctgaata tgacttttat
    14881 gagagagagg atggatatac tccattgtgt aatacatatg gactgaactt taaagataca
    14941 gttgatttag atattggatt aaaataccaa gctatcaatg aaggtaagat tgacgtaatg
    15001 cctatattta caactgatgg tcagtatagt gtttcagatg ttgtagttct aaaagatgat
    15061 aaaaatttct acccatctta tcaatgtgga aatgttgttc gtttggaagt attagaggaa
    15121 aatccagaac tatcaaaggt atttaagatg gttggagata ttttgactga taaagaaatg
    15181 gctaaaatga attatgacgt agaaaacaac aatttagaac ctagagaagt tgctcgtgag
    15241 tttctgaata agaaaggtct tttataaatt ggaggaaata taatgacacc tattatacaa
    15301 tttaaaaata ttaaaaaaca atataatgat aaaactataa tagataatct taatttagat
    15361 atagaaaaag gagagttttt gactgtaatt ggttcgtctg gttctggtaa gacaacactc
    15421 ttaaaaatga ttaatggtct gattttgcca gatggaggaa atattttgat aaaccaaaca
    15481 gatatcaaaa acgaggactt aattaaatta agaagaagaa taggatattg tgtacaggga
    15541 agtgttcttt ttcctcatat gactgttgaa gaaaatattt catatgtacc aaatctccta
    15601 agtaaaaaga ataaattaga agtaaaaagt gctgtaaaca agtggatgga aatagtggga
    15661 ttgccaaatg atatgaaagt gcgttaccca tcagaattgt caggtggtca gcaacaacgt
    15721 gtagggattg caagagcttt agcttcttct ccagaaattt tattaatgga tgaacctttt
    15781 ggtgcagttg atgagattac acgaaagcaa ttacaaaaag agataaaaga aattcataaa
    15841 aaaacaggag ttacgattat ctttattacg catgatattt atgaagcttt gattttggga
    15901 acaaagactt tggtattaaa tcatggagtt gttcaacagt atgatactcc tgagaatatt
    15961 ttaaatactc ctgctaacca atttgtagac cagttattga atataagaaa atctataata
    16021 gatgatgata atttaaaaga ataaatttaa atttaaaatc aaattgttgt gataaaaact
    16081 attgatttag agctaacttc aagttgtata cttgaagtgg aaaagttaga ttaaggtata
    16141 gaagggcatt tagcagttgg ctgtagacga ggtaactgct gaaggtgctt tcaataaatg
    16201 gctagaacct gtatctgttg aagattataa taaattgaaa taagaagctc aatatacaga
    16261 gtagataggc acttcaaata gaagtgtctt ttgtgtgcca taaaataaat caaaatatta
    16321 gcaaagaatg tgaaaaacaa aataaaataa tatgctatct ttaaaatagg agggatgcta
    16381 tatggataac aatttgatta ccattgaaaa aactttagat tatatagaaa aacatctttt
    16441 agatgagatg ttagatttaa atgtaatttc taaagagata ggctattcaa aataccattt
    16501 acatagaatg tttacatcag ttgtcggatt tagtgtacat aattatatac aaagacgtag
    16561 acttactgaa gcagcgagaa tgctaatttt tacagaaaaa ccaattattg agattgcttt
    16621 aatctcgggg tatgatacac aacgctcttt ttcaagaggg tttaaaaaaa tgtttaaacg
    16681 tagtcctaat ttttttagaa gacatcaaga ttttttacca ctacaattaa aatttgatat
    16741 tcataataga aaaaaattac gtggagatat ggttttagat gttaaaaaag ttaattgtgc
    16801 agatataaat attgttggct attctggtaa agtaagaaaa ggatttcata ttattggaaa
    16861 atgctggagg gatttgcata aaaataaaga gatgatagaa aataaggtag atttaggttt
    16921 tttaattgga gttagtgatt atagcaattt taaagagatt gagaatactc ctacatttac
    16981 atacattgca ggtgctcaag tagctacttt tggcaaatta cctaatggaa tggaaaaatt
    17041 cgtattaccg aaaagtaatt atattgtttt tacttttatt gggaaaaatg aggatagtat
    17101 gcaaaatgtt gtagaatata tctatcaaga atggttccct aattcaagtt gccagtttaa
    17161 tgaaaataat ttatatgact ttgtaaaata tggagaaaaa actgatgaga atggtttgag
    17221 tgaaattcag ttttgggttc caatcattta aaagaaggta ttatgtataa agtagatgga
    17281 tttatatagg caaagtttta cagcagtatg tatttataaa taatttatag tttgtaggaa
    17341 agaaataatt ttactataag attatgataa aatacacaat actatgacaa aatagtgtta
    17401 aataatagat ttaattttgc ataggaaaag ttctataatg gtgtgtattc ataaataatt
    17461 tataatctgt aggaaagaaa tagttttact ataagattat gataaaatac acaatactat
    17521 gataaaatag tactaaataa tagatttaat tttgcaaagg ataaggtgtt ttaataaaaa
    17581 tgaatgtaga aaacgaatta cttaaaaacc tagatagatt gcatacaaca gagttaggcg
    17641 ttgtaagaat taagaaaaat ctttctttgg agacaaatga tgtagtgaac tggtgtaaaa
    17701 ctaaaataga atctccaaat gccattatta atagaaaggg aaaaaactgg tatataagtg
    17761 tatatgattg tattataaca gtaaacgctc acagttatac aattattaca gctcataaag
    17821 aaaagaaatg aattgcaaaa tacaaaggtc aaaagcattt tccactgttt gtagtaccta
    17881 tgaagaagta tataaaataa tattactttt gaataataat ttaaattttg gaggttgaaa
    17941 aaatgaatga tactgtaaaa gaaaaattgg cagagtcact aacttctgat actactgata
    18001 ttttacctta tttgccttat ttattacaag atttttggga attaggaagt tcaccagaac
    18061 aaatgttaca attatttaga aagcatatac cttttaatga ggatacaaaa gttttggatt
    18121 tagcttgtgg aaaaggtgct gtatctgtga agcttgcaaa agagttgaat atacatatca
    18181 aaggtattga tttgatacct gaatttatta attatgctag aagaaaggct attgaatata
    18241 aggttgatgc tttgtgtgat tttgaaatga atgatgctaa tagttctgta aaaattgagc
    18301 atgattatga ttgtgtgatt tttggagctg taggggatat tttaggtaat tataaagaaa
    18361 ctataagtaa gctattacct acaataaaaa gtaaggggtt cattttaatt gatgatgcat
    18421 atgtagtaga taaatctaca aatgaacagc ttaattttga gagggtgtat cccacttaca
    18481 atgagtggtg tatattgttc aaagaattag gtctgaagct aattgaatgt ataccatgtt
    18541 tagaacttga aaatgatgtt gaagaggaaa tgaattggat tataactcgt gcaaatgagc
    18601 taattaaaaa atatccttct caaaaagata tgtttgaaca atatgttatt agccaaaaaa
    18661 atgaatatac tgatttacag caggaccttg ttggagcaac ttggatttta caaaaagaat
    18721 aagataaata ttagactaga taatcaatgt tatagtgaat tatcccatgt ctagtgaata
    18781 taaataacat aaaaaaccgt caagatgaat agtttattcg tgcttgacgg tttttagtat
    18841 ttgttgaagt aaaattttat ttctttagta tatcactttt agtcaatcca tttgatttag
    18901 cttgagtatt ccattgatga ttccccataa gtttatatag gaatctaggg aagttaggtg
    18961 aaataaaaat agtacttttg ttggaatcat ctatatgtat attatcacta agtatatttt
    19021 ttgaaagttc ttttaatgca attcctaaat cttttttagg tcctttaccc aaaggtacgg
    19081 attctagtga accaaacatc tccccagctc caattccaat accttgaacc catgtaaagt
    19141 tgattttttt acaccaatgc tctatcattt gaattgccaa atgattatgt tcaccttcat
    19201 tgaatccaca gttaactatt gcatacactg gaataggttt tttattttgt gtttttaaaa
    19261 atttttcaca tttctctaaa aaatgaagta aatgagatgg aataccatct acataaagag
    19321 gagatgcgat tattaatcta tcacaattaa gtatggcatt aagagcgtca ggatacttag
    19381 atgtgctatc tactttaaat gtaaaaactt tattatcatt ttgaataagt tgttttaatt
    19441 cagataaaaa atactgtgaa ttatttttat ttacttttgg actaccattt atcattacta
    19501 tattcatatg gattcacctc ttatatcttg tatattttca tagaaacaaa cagagtgttc
    19561 ttttatattg aaatttatag catttccatt tactaatttc gtagcagttt ctttttcagc
    19621 ttctgtaata caatctccat agaatatagc ttttaaattt atctgtttat catatctgct
    19681 tttatgacgc atcatattat cttttattac aaagtatgga agaatataat taatgctttt
    19741 atcaagtacg tttttgacaa aagggctaaa ccctccgtaa cagcatctgc ttattataat
    19801 aattccatca gagtcattta taagtttacc catgttgctg taataatctt ttacaacaca
    19861 ttcagaagga gttttaatcc agcaaccaaa acaaccaata catttgtgga tttcttttgt
    19921 gtttggaagt atttttatat tgtcatcaag tttgggtaat aacttttcta attctttgtc
    19981 agttaaatca tgtattaaaa gcctcataaa gtccatctcc ttttattatg tatgtttact
    20041 tctaaaaatt atatcttata gatttttcag taaatcttta caccaattaa taacaaaatt
    20101 ataatagtca actccataaa tcattgttgc atacatatat gtatattggt caacgcaatg
    20161 attttcttct gcatcatttt tttgtttact taatttattt agaagtaatt ctacttcagt
    20221 tattaacatt tttaagtttg tttcaattat ttctttgggt agatacttgt aaaagaatat
    20281 attaacaagg tggtcttgct ttgttttaga aaaatttata ggtttcttta accattcaag
    20341 aaatacttct ttaccagtat tagttatgga atataatttt tttaatttgc taccatctat
    20401 aacttcgtga tagtgtatat atccttttgt ttctaatctt ttaagtgcag gatagatact
    20461 tccaaagctg gcgtcaaaaa agtacgaggt actttctgac attatttgtt ttaagtcgta
    20521 tccacttaat tctttttcca ttaaaaatcc taaaataatg tattctaaca tattacctcc
    20581 tggtatcaat tagatatata tcgattcgat atatttatta ttacagataa taaatcttac
    20641 gtcaagatgc tttttaagat aagctaaaaa gaattaggag ttattgataa atatgcaaaa
    20701 aaattaatat aaaaggtaat taaatatcaa tgaagattta aaaatagtta aatcaaagta
    20761 agagtctaat atataaaatt tatagtaact ttatggttta aatataaact tgcgtgctat
    20821 tgacaaagta taaaattagc agtaaaataa ttgcatgagc aaatagatta ttgcgaacgc
    20881 aaaaaaataa ggacaataga tattaaagga gagaatatga gagagctatt aaaatgggtt
    20941 tccattataa atagatacaa tacaaattat attgacagga aattggcgga tattggaatc
    21001 aataatagcc aatattttta tgtattacac atatgtaata atccaggtat tacacaggac
    21061 actatatttg agaaaattct tgtgaatcct agtaatataa caagagcttt ggcaaattta
    21121 gaaaaagaag gctttataac aagagaacca ggtgtaaagg ataaaagaac atggcattta
    21181 tatcctacag aaaaatcttt aggatgttat gatgaaatac taaaaataac aaatgggtat
    21241 gttgaggagt tgttgagttc atttgagaaa gaagagcaag agttgtttat gtcaatgtta
    21301 aagaaagttg catttttggc tattgatatg aatgaagaag caaaattgga ggcgaaggaa
    21361 aatggaagaa aaatataagg agccattgga atatgaaaag gtttcaaagt tattaactaa
    21421 gtacgcaatt cctagtatta tagcaatgtt agtaagtgct ttatataaca ttgttgacca
    21481 aatatttatt gggcaaggtg ttggtgtatt gggtaatgct gctacaaatg tcacttttcc
    21541 actaacaaca atatgtactg caattgcatt attgttagga attggaggag cgtctaagtg
    21601 ttcattggaa ttaggtgcta aaaattcaga aaaagctaca aaagcagcag gaaattctat
    21661 atgcttgatg gctgtttttg gaataagttt atttatagta gtatcaatat ttttaacacc
    21721 actattaaaa ttctttggct ctacatcaga aatactacct tatgcacaca catatacaaa
    21781 aattacatca attggattac catttcttat aatgtccact ggaatgagta agttgatact
    21841 tgcagatggg agaccaaaag cttctatgtt ttgtatgtta ataggagcag ttattaatac
    21901 aattttgaat ccattattca tttttgtttt taatatggga attgctgggt ctgctttagc
    21961 aactgttatt gggcaactta tatcttttgg aataagtgtt cattatataa agaattttca
    22021 acatattaaa ttacataaga aaagttttaa attagatagt ataatttata aacatatatt
    22081 tgcgctaggt tcaagctcat gttttaatca attagcaatg actgtaacac agatagttat
    22141 gaataataca ttggcatatt atggggctag gtcagtttat ggaagtgaga ttccacttgc
    22201 ttgtgtcggt atcattatta aagtaaatat gatttttata tctataatta ttggtatatc
    22261 acaaggtatg caaccaatta tagggtataa ttatggggct gaaaagtata atcgtgtaaa
    22321 agaagcatat aagtttgcag tgggaagtgc aactattata tctgttattg cattcttatg
    22381 tttccaattc ttcccaagac aaattacgtc tatatttggt aacggaaatg agacttattt
    22441 tatatttgca gaacattatt ttagaacttt cttgttctta acatttataa atggtgttca
    22501 aatagtatca tcaactttct ttacatcaat tgggaaatca gtgttgggac tttttacttc
    22561 tttgactcgt caaattttat ttttaattcc attgatagta attttaccaa tgtttatggg
    22621 aattgatgga gtaatgtttg caggaccaat agcagatgca gcagcggcaa tggtatgtat
    22681 atactttgca gttcatgaaa tgaaatcatt gactataaag caaaataatt tgatgagtaa
    22741 ccataataag attgcagagg tataagacaa tatttaagaa gtatagaaaa ttaatttaaa
    22801 aaatataata aattaattta ggaagtgtag aaaattaatc taaagaagta taataaacta
    22861 atttaggaag tatagaaaat taatctaaag aagtgtaata aactaattta ggaagtatag
    22921 aaaattaatt taaagaagta taataaacta atttaagaaa tatagaaaat taatttaaag
    22981 aaatacaata cattaatttt taagtaacat taaattaatg taagtaaaat aatgttcata
    23041 tgaatattta aaggtgcatt ttctgaagct aagtatatgt tgtagagtgt tatgtctctc
    23101 tatcctgtga agtttaatag ctcaagaaaa tgcactattt atgatgatta ttttgtttta
    23161 tttccaattt tggaaataac tattctaatt aaatctaaaa ttataccata aataagaaaa
    23221 gaaagtatag atgctatgta ccaataaatc gaaattgacc ctgtaattgt tctacatggg
    23281 atttgcatac ctgaatccat aaaaacaaaa aaactatcaa ctctggaaat aatagacaaa
    23341 ataggattta aacctattag aacaatactt tttgagtctt gaccaatttg atgcatataa
    23401 atctcaaata atgcaattaa aaaaaaccaa gatgtaaaag atttaataat ttttttcatc
    23461 aaaatacctc acataatata aattctgttt gcactatttg cttactacaa ctatttatct
    23521 ccattcagtc acatcactta attgtaatct aggtcttctt gatggttctt catcaggata
    23581 acctaaagat attgctgcca ctaattgact atctgtattt aaccattcac ataattcacg
    23641 atatgcaaag tatacatcac aaatccaaag actacctaga cctaattcca cagctgtaag
    23701 cgacatattc tgaattgcag ctccaattga ttgcatattt gccatttcat agaatcgttc
    23761 ttcaggggat agcttttcta aaggtgattt acctaatata tttaaaataa aaattgttac
    23821 tggagcttgt ttcatgattt caactgtgta atttgcacca gcgatatgtt gacgacttcc
    23881 tggaagaagc ccattatcat taatttcatt ttgaatacct ttgctcatgg ctttaagcat
    23941 agattctttt tccttttcag tgatgacaac aaaacgccat ggttgcctgt ttttagatga
    24001 aggtgcattt attccagctt caattatttt ctctatagtt tcatgtgaaa tgctttgatt
    24061 tttatatttt ctgatacttc gtctttttga tatagaatca cttatcattt taagtaacct
    24121 ccgtttattt tttggaaaaa tctatttaat ttttattttc tattttaatt attttagcat
    24181 taatcagaaa aaaagtcatt gattttagta tacaattatt aatgattata ttaagaattg
    24241 tatcaaaaag tatgtgatta tactaaggga ttatattaaa cattatattt aaaattgtat
    24301 gaaaggttgt atttaatatt atattgagag atatatatat taggatttat atatattcag
    24361 atttattatt atattgagtc ttatattaaa ttaaggacta taatttgaaa ataagctata
    24421 aaaactcaat attgttttgt tcaaagataa aaaaagaat
//
LOCUS       DAEHWM010000060        24024 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.061, whole genome shotgun sequence.
ACCESSION   DAEHWM010000060 DAEHWM010000000
VERSION     DAEHWM010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 24024)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24024)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24024
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.061"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     regulatory      152..253
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            326..1669
                     /locus_tag="KNP36_002398"
     CDS             326..1669
                     /locus_tag="KNP36_002398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HBF0874263.1"
                     /translation="MVPNTNNVQPGGNNSSLSFLDKMFKFSERGSSLKTEVIGGVTTF
                     LTMAYIVFVNPAILSEAGMDKAALITVTILATAIGTLIFAILGNAPFALAPGMGLNAF
                     FTYSLVIGAGIPWQTGLGVVFLSGCVFFTLAVTGLRKTIADAIPRELAVASSAGIGLF
                     LAFVGLKNMGVIIANPDTIVSLADFTPTVLIALFALILMAILEYKKVKGGILISIVVA
                     TIISVIFGFVELPTAIISTPPSIAPVAFKLDIVGALKFSLIGPIFSFMFIDMFDSLAF
                     LITCCKQMGLEDENGEIKDLGRMLYADVSSTLIGSFLGTSTVTTFGESASGIAAGART
                     GLASIVTAALFLATLIFTPLLGIVPTYAAAPALVMVGVFMFESIKQIDFADSKIAVPA
                     FVTVLLMPLTYSISIGLCFGFISYIIMHVVAKETDKISITLWIIGLLAVVNLVLS"
     gene            1848..3212
                     /locus_tag="KNP36_002399"
     CDS             1848..3212
                     /locus_tag="KNP36_002399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0874264.1"
                     /translation="MSQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIV
                     DKDAEIYDAKGKILMPGLVNTHVHLSQQLGRGLADDVVLLTWLRERIWPYESSFNYED
                     SLISSTACCVELIKSGVTTFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEA
                     WQKTTDEEINTQLDLFHKFNNTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGI
                     HMHIAEIADEISFVKQNNGVGTVEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVK
                     VSHDPGSAMKVVLGFASIPEMLEKGIPVSIGTDGAPSNNRMDLMRDMYLTSLIHKGRT
                     LNPTVVPAEEVLEMATINGAKCALLEKEIGSLEVGKKADMIILNPDTIHCLPMHNPIG
                     NIVYSMTSENVDSTICDGKWLMKERKVLVVDESELLNKVKKQASKIKDKAEVKIPSKF
                     KIIK"
     gene            complement(3390..5255)
                     /locus_tag="KNP36_002400"
     CDS             complement(3390..5255)
                     /locus_tag="KNP36_002400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIRAN domain-containing protein"
                     /protein_id="HBF0874265.1"
                     /translation="MENVFKRLQEFNGYDGYKESFEMNYLCIYESIPLREQVELANNL
                     VDEILNMYKSESNEIYLLEGSNSKSLICYFEIFMKKINTLVKEMIIDEKWLYKLTKEL
                     IYKSKKVEYVKLGLVLSEKYLNVENLREVVDTFSKSGEYVFYLSNTIKKLEFYNTYLF
                     NLSKKATGSIKVFAIVNMENLDSKINSYLIEDGYKDTKYERLLMNYIISIVDLNEYLE
                     KRDLDKEKINNLARLICNYLLSVEFKYIGNKLELVNRFLPTVVNYGTNFESLYSIFLI
                     AINVLKDENIECNKIEFEKEINGILLSEKWKNIYFEALRDASGKTEDIIKMSEIYDVN
                     LSFDDLLPYLNRDIRDFEVYWHISKKGTTSSRLKLLNFFEETFKIDDLIGKMKDIEKD
                     KLTQEYYDDMLFFIVLKGSKSLYPEGKNISLKGIFGNINEVRKESINILKRYREKLSL
                     EELKIVKEAYEKEKNVILKDELRRVLYESNNLKKEFVNIEKIKVDEHGKDIYLTSIAV
                     AGSRFRNREYLEKELEKSKIYYLTREKDNLYDEKAIKIVGETGYVIGYVPRKENYILS
                     NLLDGGKLLYCRVTEYNLYEDCIYANVYLSYKDVIETVENSLKMVLDKSRIKLIN"
     gene            complement(5491..6708)
                     /locus_tag="KNP36_002401"
     CDS             complement(5491..6708)
                     /locus_tag="KNP36_002401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0874266.1"
                     /translation="MNNKKYYPTAIALYFSYFLLGIGISILGQYKPEFSSMWGAKTLS
                     DGTLDVSIVLAVIAALGLGRLISYPFAGPISDKYGRKVSGLIGNFLHAIFFVGIVFSP
                     NFYIAYVFAIIGGAANSFLDTCVTPSCMEIFASLGTIANMFTKFTIALAQFLLPFIIG
                     FVAANSISFKVIFIVTAILIVVDAFLIAVLPFPPANNVIDNKGKTVKSEKMKFTPTSI
                     ALVCIGFTCTSTFVLWLNCNQELGKLYGMADPTKIQSFYSMGVICAVLITSLLIKKYI
                     KPIRILVIYPIIALLMLLVVYFVQTPTICMLGGFVIGYSAAGGVLQLTTSTANEMFPT
                     NKGKITSIVMIASSIANYVILNIAGIITKSGGVNGPKYVVLFNVAITFVGILLALFVN
                     MRYEKEKVYDYDV"
     gene            complement(6908..7771)
                     /gene="aroE"
                     /locus_tag="KNP36_002402"
     CDS             complement(6908..7771)
                     /gene="aroE"
                     /locus_tag="KNP36_002402"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HBF0874267.1"
                     /translation="MEISGRTGLFALIGTPVGHSKSPVMYNYSFKKLDLDYRYLAFDI
                     TVDKVKEALLAIKTFNIKGANVTMPCKSAVTEYMDELSPAARIIGACNTIVNDNGKLV
                     GHITDGVGYVRNLKENGVEVKGKKITIMGAGGAATAIQVQCALDGAREISIFNPKDDF
                     YKRAEQTVENIKKDVPECVVNLYDLEDTNKLYEEIQSSDILTNATLIGMKPYDNETNI
                     KDTSVLRKDLVVTDVVYNPKKTKMIEDAEANGCKAIGGLGMLLYQGAEAFNLYTGLEM
                     PVEEVNELCFK"
     gene            complement(7853..9775)
                     /locus_tag="KNP36_002403"
     CDS             complement(7853..9775)
                     /locus_tag="KNP36_002403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBF0874268.1"
                     /translation="MKISSMFTPIRIGSMTVPNRFVVPPMGNNFANTDGTLSETSKAY
                     YLERALGGFGLITIESSVVDKKAKGGPRKPCLYDDSTIDSFKNVIDACHDAGSKVSIQ
                     LQHAGSEGNEKVAGHPLKAASAIPASNGRNTPLAITTEEIYELIESYGDAALRAQKAG
                     ADAVEVHCAHGYLVSSFISQRTNKRVDEFGGCFENRMRLPRLIIENIRKKVGNSLAIL
                     CRINSTDDVPGGIDVHDSSVIAAYLEDCGIDGLHVSRSIHIHDEYMWAPTTLHAGFSA
                     ELVTEIKKAVSIPVITVGRYTEPQFAELMVRQGRCDLVAFGRQSLADPEMPNKAKNGK
                     LDEMIPCIACLQGCVPNMFQGKPIACLANPILGHEAELKPAEISKEVLVVGGGVGGML
                     AAWVCAKRGHNVTLVEKSEVLGGQMRLAAYPPGKGDITNLVRSYISKCNQYGVKICTN
                     TEATVELIKEKSPDVVIIATGATPLVLPIPGINDSGLIHAVDLLDGKKSCGKKVLVVG
                     GGMVGCEVAAFLGEQEHEVTVIELREEVGADVISEHRKFLMNDFENYNIHTITGAKVS
                     KFYDDGVDYLLTDGTEHDLKGFDSVVLAMGSRNYDPLSEVIKEVVKETYIVGDAVKAR
                     RALDATKEAFEVALNI"
     gene            complement(9839..10687)
                     /locus_tag="KNP36_002404"
     CDS             complement(9839..10687)
                     /locus_tag="KNP36_002404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="HBF0874269.1"
                     /translation="MNNQKNLNIPITISSYTLGTEVSFRDRVRIAKEAGFDGIGLRAE
                     NYIDAKNAGVTDEEMIAILNEYDMKVTEVEYITQWGREEDRTEAQREKEQNVYHMAHL
                     FNVKHINCGLLEMIPEEQIITALGELCDRAGELIIGLEFMPYSGVPDLATAWRVVKGC
                     NRENAMLILDTWHWARAKQTAEDLAPVPADKIVSIQVCDVLETPYEKLRDESLHDRLA
                     PGEGYGNTEEFVKIIKEHNISPRVIGAEVISDSLISKGLSTAAETVFNATKKVLDKAW
                     SEVSPK"
     gene            11100..11981
                     /locus_tag="KNP36_002405"
     CDS             11100..11981
                     /locus_tag="KNP36_002405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0874270.1"
                     /translation="MNLYHLRYFVTLAHLEHYTKAAENLSITQPSLSHAISLLENELG
                     VALFEKEGRNIVLTKYGKIFLKDVEKSLEILDSSVKSLKITGTGEGQIDLAFLRTLGT
                     DFIPDIVHKFLKSNPAKSIDFKFHTGVTTDIIQGLKERKYDIAFCSKLEKEKGIEFIP
                     VAKQDLVLIVPYSHPLAAKDTIDLKETIPYPQIVFNQRSGLRYIIDDMFKKINQQPNI
                     VYEVEEDQVIAGLVAKNFGIAVVPNMNMLSFTKVKVIQIIHPSWERNFYLAFIKDRYL
                     PPAIKNFKNFVIKNAQL"
     gene            complement(12189..13052)
                     /locus_tag="KNP36_002406"
     CDS             complement(12189..13052)
                     /locus_tag="KNP36_002406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3800 domain-containing protein"
                     /protein_id="HBF0874271.1"
                     /translation="MLSSYVKRVSKIIKKKYIMFIDESGRADINHEDPFTLTGVIFEY
                     KYAVSQGDYVCSLRKEMDAFKEYCFGTSNIGIHLTDISRKSRAFEKFDDSQIKLFYDE
                     LPLFLSRLECTIISVTVDKARLKKYYAPSKEPYVVAFIHVLQNFYSFVNNETVESARI
                     VIESRDDVSNLKVQKAFFDVFNNGTIYLDIDEELRDKVKGFIIAKKEDADYREGLEIA
                     DILCNPLSRARRGLIEANPKCMQYGEKNKIFKSVRNKIYTPTSVNDIRNWGFKEVPIV
                     EPVGPWLEKMR"
     gene            complement(13207..15141)
                     /locus_tag="KNP36_002407"
     CDS             complement(13207..15141)
                     /locus_tag="KNP36_002407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp22"
                     /protein_id="HBF0874272.1"
                     /translation="MKKSLKKYLVLALTLVLVFACGVPESSAASKHVIIVNSRKNTLG
                     YFVNNKLVKEFRVATGKKGSETPTGKTKVVNKIKNRPYYKGNIPGGSPRNPLGDRWMG
                     LALKGTYGDTYGIHGNNNESSIGKHISGGCIRMHNKDVRWLFDQVPVGSDVIIDYSND
                     SYVKIAAKYKINLNQTGWKTENGKKYYVKSDGTYQKNSWLKVNGKMYYFDASGVMQTG
                     WKTINNKKYYLGTDGARVSGWKVIDGKTYYFNSDGVMQTGWQEKNGKKYYLGSDGLAV
                     TGWQEIDGNKYYFDKTGIMQTGWQQIDGKSYYLDKDGKMLTGSQKIDGKDYTFNEDGT
                     INPTWDTIIGANRFDTAKKISSVGNWNADSSDTVILVNGNAIADGITATPLASSYDST
                     ILLTNTANLPTETVEEMKLLAPKTVILIGGENAISSKLEQEIKTTFNTETKRIAGQDR
                     YQTATRIAEELGNREEIKTAYMVSGNGEADALSVASKAGEEKQPIILVNKDGITEESY
                     KWLTERKLENAYFIGGPSAINDSVIAKMNDITTEDISGNRIYGDSRVDTNAKVIEKFY
                     GDTDLQAVLVSKSDALVDALSAGPLAVKLHSPIVLMDNSGLSSEQQRVFANKKVETPY
                     QIGGGVSYIVMDKLMDILAK"
     gene            complement(15253..16266)
                     /gene="galE"
                     /locus_tag="KNP36_002408"
     CDS             complement(15253..16266)
                     /gene="galE"
                     /locus_tag="KNP36_002408"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HBF0874273.1"
                     /translation="MAVLVAGGAGYIGSHTAIELLESGYEVVIVDNLSNSNSIVVDRI
                     KELSKKPVKFYNIDIRNKDEMHVVFKENNIESIIHFAALKAVGESVEKPIEYYSNNLI
                     STLNLFELMREYGVKKFVFSSSATVYGDPHTCPILEDFPLSVTNPYGRTKLMIEQMLV
                     DISKADKSLDIALLRYFNPVGAHKSGRIGEEPNGVPSNLMPYITKIAVGKLKELSVYG
                     NDYPTHDGTGVRDYIHVLDLAAGHVKALQKLEENPGLVVYNLGTGKGYSVLDLVKAFS
                     KASGKEIPYKIVGRRAGDVAMCYADSSKAEKELGWKAKYELEEMCEDSWRWQSMNPNG
                     YEE"
     gene            complement(16290..17159)
                     /gene="galU"
                     /locus_tag="KNP36_002409"
     CDS             complement(16290..17159)
                     /gene="galU"
                     /locus_tag="KNP36_002409"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HBF0874274.1"
                     /translation="MTVKKAIIPAAGLGTRFLPATKSQPKEMLPIVDKPTLQYIIEEA
                     IESGIEEILIITGRNKKSIEDHFDKSVELELELEQKGKTEMLEMVRDISNMVNIHYIR
                     QKEPKGLGHAIYCAKSFIGDEPFAVLLGDDIVDSDVPCLKQLIDTYNEYKTTVLGVQK
                     IAKEDTNKYGILDVKHIEDRVYKVKDMVEKPAIEEAPSDIAILGRYIITPAIFSILEK
                     QTPGKGGEIQLTDALQTLGKQEAIYAYNFEGRRYDVGDKIGFLEATIDFALKRENLKD
                     DLMDYMRKKVSEK"
     gene            complement(17357..17677)
                     /locus_tag="KNP36_002410"
     CDS             complement(17357..17677)
                     /locus_tag="KNP36_002410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874275.1"
                     /translation="MSSKYNVWTFNYEFLGLDSGDEKNNEVYYEIDLDEILNENYIDE
                     DIDSGLDSDGNSILGELISEMDIDEDVSVDMTYQELEVDLEDLDSYLDEDIDSDIKGI
                     LDEI"
     gene            complement(17667..19658)
                     /locus_tag="KNP36_002411"
     CDS             complement(17667..19658)
                     /locus_tag="KNP36_002411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874276.1"
                     /translation="MLKLGEKIIYELSDGFELSGISRYSKEYKKLHITNLGNIIISKS
                     DEVNEDTGVKYIYSFSDNKEKLEAVLEDSQIIVYGNNLPFYIKSENSSKNVTANLTMK
                     ITLDEYDLICKSQREFIFYLKDNMTILSLDDNKFYMGGINKDNEKFIFISGKNRFEIN
                     FDDIERYILEDKRVSLKGYFHMEREGIIVRSVSIFNNNIDSVVPSDLNERVKDNQKIG
                     NLPKDCEIVFCKISGNIDGFDYKNTNMLLVKYQDQLIFINKKSKKTIVKSAKDNCSKL
                     NLGEDIILYDNKNVFNLHINDKNREIMQIDDLKDIENEIVGYTLKHAPFFIQEDFDSL
                     TILKSFQKEIISIKNSDIKDIVINKELENENSNFVETEIKFNNQKVLLNLSKSMVQKL
                     MQDVFIYAKQPLLKENSIEVIYKNWSKAMNDMIIFNFFGNIYYMKSEFDKILEKELND
                     EIRIEVINSLYKQIQEQRNNLDLLSAYMPRILENQEIDLFEKYNTKLDVQVFKQIKNL
                     LSDLSYNISSYLNEVEKSLDNIIFVISGEDKKKYNYRMLKESESASLDVFLKQAISRL
                     NHLVENMYPYYVDETSREMFKLFELLWKNYRNIDDDSIKEILFERITNTYVFKQLTLN
                     NSTKERRKDIIEKIYNSVDYGTNKLDENMFFTGGIKYVK"
     gene            complement(19781..22324)
                     /locus_tag="KNP36_002412"
     CDS             complement(19781..22324)
                     /locus_tag="KNP36_002412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPOR domain-containing protein"
                     /protein_id="HBF0874277.1"
                     /translation="MKVLSENNIIRNTVLNVTASFLKQESKINEKLDGVLEKKFEKVE
                     FNEAKYAELLKFNILFYKTLARNTEPLIGKWIVDKYIPEIDELEKDLELTTAKCRKYV
                     NKAMKEGLDSLKANDLNSFLAYDKMELSERRRRLEKDYKVLNLYKDLLNISLRKISLE
                     KKECGDLFLKNQADAKRELKREIIFCVNKILASNKDVVPNNVEENNEQNKVEIKATEI
                     EDLQLGKDNSENDMLLNEIKNSKVKHESKSNDIESKFIDKLNSLNNESISQTIHNEYK
                     KLCGLEELHSVEAYGFGKEIIKDFACATVVLEFLKRRNRDLIEGAMRLTIIGEFGPEN
                     FKEFVDYVIKNKTEISEDTWNKAQNLIKDNYSELENHEIASKRTRRNKDIDIEEYIYM
                     IKNADKDICFRSSISIEDDAEEGTKEEVDSNNQDIGDVVEDKDTTDKEYDSNKEDIIE
                     PENKKSKKKAKLFGFIKKDNEEAEQEEENLNDISPDIILDKPVENHQVKSEEIEQNEL
                     KEIKQEEPSQHIEEERSVKIEKPINNNLDEKVSSNNESKLEKESKNLEDKKAKEIKEE
                     KLENEKSVVIPIKKKENSNKKSKNSSKDKYRENKKEMKNYVSDKEDSLDDEEVVSKKS
                     RLKETIIAVVIVVIVGVGYFITVGNNKKNDKENIPKSSTQQQANNKLTEEEKKAQAEK
                     EKKEAEEKAKAEKEAQEKAQAEKKAKEMEAYKDGKGVYYTVYAGSLKVEKTAKETAKE
                     YEAKGISSTIIQENGYYKIKIGDYSQYGEAQEKCNELAKKSIDTYIAMYDKYYDYKLE
                     ELKESAPSLSAEELKQKYEDLRSELKNKSGYREYVKHLDKLYEEIVEGA"
     gene            complement(22602..22936)
                     /gene="rnpB"
                     /locus_tag="KNP36_002413"
     ncRNA           complement(22602..22936)
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="KNP36_002413"
                     /product="RNase P RNA component class A"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00010"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00010"
     gene            23068..23745
                     /gene="srtB"
                     /locus_tag="KNP36_002414"
     CDS             23068..23745
                     /gene="srtB"
                     /locus_tag="KNP36_002414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtB"
                     /protein_id="HBF0874278.1"
                     /translation="MKKLYRIVINIILVLVILYSGFNIYSKLTKYNHDTKISSELQKK
                     EYKKEDLSKINSDFKFWLSVENTNINYPVVQSKDNSYYLDKDFYKKDSISGTLFMDYR
                     NKSIDDKNIIIYGHNMKNKTMFNNLNKFKDADFFKKNNKIKITLNGKEFLYDVFSAYI
                     VESDYDYLKTNFNNESDYQNYINDITSKSLYKSPIKVNSNDKIVTLSTCTYEFDDARM
                     VIHGRLI"
     gene            complement(23905..23979)
                     /locus_tag="KNP36_002415"
     tRNA            complement(23905..23979)
                     /locus_tag="KNP36_002415"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(23945..23947),aa:Thr,seq:tgt)
BASE COUNT         7671 a         4154 c         2710 g         9489 t
ORIGIN      
        1 gaataattga cattatactc atacatattc aattattgga aaaagtaatt tttttcaata
       61 aataacctta attttttata aaatcgacaa aaaaacgaat aattttatta tatttattgt
      121 aaataataca atattacgat ataatacaac agaaaaacaa atagaaaatg ttcatataat
      181 attagtaata cggtctaata gtttctacaa actcacctta aatgggtttt ctatgaatag
      241 aatgtcaact ctgaatatat gttctattct atctatatga atatatattt ttttgtttat
      301 atcttaaagt tttttggagg taaaaatggt accaaacact aacaatgtac aaccaggtgg
      361 aaataattca tcattaagct ttttagacaa aatgtttaaa tttagcgaac gtggctctag
      421 ccttaaaaca gaagtaatag gtggagttac tacattctta acaatggcat acatagtttt
      481 cgtaaatcca gcaatattat ctgaagctgg aatggataaa gccgccctta taacagttac
      541 catactagct acagccattg gtacacttat atttgcgatt ttaggaaatg caccatttgc
      601 tctagctcct ggtatgggat taaatgcatt tttcacatac tctttggtta taggtgcagg
      661 aatcccatgg caaacaggtc ttggggtagt ttttctatct ggatgtgtct tctttacact
      721 cgcagtaaca ggtcttcgaa agacaattgc agacgcaatt cctagagaat tggcagtagc
      781 atcttcagca ggtataggtc ttttccttgc ttttgttggt ttaaaaaata tgggtgttat
      841 aatagctaat ccagatacta tagtttcact tgcagatttt acaccaacag ttttaatagc
      901 cctttttgct cttatcttaa tggcaatact agaatataaa aaagttaaag gtggaatatt
      961 gataagtata gtagttgcaa caataatatc tgttatattt ggatttgtgg agttgccaac
     1021 agcaataatc tcaacacctc ctagtatagc accagttgct tttaaattag atattgtagg
     1081 tgcattgaaa ttctcattaa ttggacctat attctctttc atgtttatag acatgtttga
     1141 ttcattagca tttcttatta cttgttgtaa acaaatgggt cttgaagatg agaatggtga
     1201 aataaaagat ttaggaagaa tgttatatgc agatgtttct tctactttaa taggctcatt
     1261 cttaggaact agtactgtta caacatttgg agaatctgct tctggtattg cagcaggtgc
     1321 aagaacagga cttgcttcaa tagtaacagc agcattattc ttagctacac ttatatttac
     1381 accattactt ggtatagttc ctacttacgc tgcagctcct gcacttgtaa tggttggtgt
     1441 gtttatgttt gaaagcataa aacagattga ttttgctgat agcaaaatag ctgtacctgc
     1501 ttttgttaca gttttattga tgcctttaac ttatagtata agtattggtt tatgctttgg
     1561 atttatttca tatataataa tgcatgtagt agctaaagaa actgataaaa tcagtattac
     1621 actttggatt ataggtttac ttgcagttgt aaacttagtt ctaagttaat atttttaaat
     1681 agttctaggt caatatttta aattatatag aataaaatct tatttatttt aaatttataa
     1741 atagcaaaat cactttatat gtaaattgat tttgctatta actttgtata gaaaatttat
     1801 tatcataata tatagatata aaaatatata gaaaaggagt ggtgtttatg tcacaattac
     1861 ttataaaaaa tgcatatcta attactatga atgcagatag agaggtatat gaaaatggaa
     1921 gcatacttat tgaaaataat attataaaag aggttggtaa gtttgatatt aatattgtag
     1981 ataaagatgc agagatatat gatgctaaag gaaaaatact aatgccaggg ctagtcaata
     2041 ctcatgttca cttatctcaa caattaggac gtggtcttgc agatgatgtt gtacttttaa
     2101 cttggcttag agaaagaatt tggccatacg aaagtagctt caattatgaa gattccttga
     2161 tttcatctac tgcatgttgt gttgaattga taaaatctgg tgtcactaca tttttagaat
     2221 ctggtggtca atatgtagat gctatggttg aagctgttga taaaactgga cttagagcct
     2281 gtttagctaa atcagttatg gatacaggag atggtcttcc tgaggcatgg caaaaaacta
     2341 ctgatgagga aatcaacact caattagact tattccataa gtttaataat acatctaatg
     2401 agagaattaa aatatggttt gcattaagaa ctatttttaa tacaactgaa gaattacttg
     2461 ttagaactaa agaactagct gataaataca atacaggtat acatatgcat attgctgaaa
     2521 tagctgatga aatttcattt gtaaagcaaa acaatggagt tggaacagtt gaataccttg
     2581 ataaactagg tgtattagga ccaaatcttt tagctgctca tacagtttgg cttactcata
     2641 aggaaattga tttatttaga ttacatgatg taaaagtttc tcatgaccca ggttcagcta
     2701 tgaaagtggt tctagggttt gcatcaattc ctgaaatgtt agaaaaagga atacctgttt
     2761 caattggtac tgatggagct ccttcaaata atagaatgga ccttatgagg gacatgtatc
     2821 ttacatcact aatacataaa ggaagaactt taaacccaac tgtcgtacca gctgaagaag
     2881 tcttagaaat ggctactata aatggagcaa aatgtgcttt actagaaaaa gaaattggta
     2941 gtcttgaagt aggaaaaaaa gctgatatga ttattctaaa tccagataca attcattgtt
     3001 taccaatgca taatccaatt ggaaatatag tttattctat gactagtgaa aatgtagact
     3061 ctactatttg tgatggtaaa tggttgatga aggaaagaaa agtattagtt gtagatgaat
     3121 ctgaattatt aaataaagtt aaaaaacaag cttctaaaat aaaagataaa gcagaagtta
     3181 aaattccatc taaatttaaa attataaaat aacataaatt tcaattgttt tgtaaatatg
     3241 aatatataaa tatatttata tacatcatat atacaaaaca attgtttttt tattttatat
     3301 tcattagcat tgctcataaa atacaccata attccagaaa aaataaccaa tcagttagga
     3361 ttacatcatc taagcaatat ataaacgtct tagtttataa gttttattct actcttatct
     3421 aaaaccatct ttaaagagtt ttcaactgtt tcaattacat ctttataact caagtacaca
     3481 tttgcgtaga tacaatcttc atataaatta tattcagtta ctctacaata cagcagtttt
     3541 cctccatcta ataaattgct caaaatatag ttttcttttc ttgggacata gcctatcaca
     3601 tatccagttt caccaactat tttaatagct ttttcatcat atagattatc tttctctcta
     3661 gttaaatagt atatcttact tttctccaat tctttttcaa gatattctct atttctaaac
     3721 cttgaaccag caacagctat tgaagtcaaa tagatatcct taccatgttc atctactttt
     3781 attttttcaa tatttacaaa ttcttttttt aaattattac tttcatataa tactcttctt
     3841 aattcatcct tcaatataac atttttttct ttttcatacg cttctttaac aatttttaat
     3901 tcttcaagag atagtttctc tctgtatctt tttaagatat ttatggattc ttttcttact
     3961 tcatttatat ttccaaatat tccttttaaa gatatattct ttccttcagg atatagtgat
     4021 ttacttcctt taagcacaat aaaaaataac atatcatcat aatattcttg agtcaattta
     4081 tctttttcta tatctttcat ttttccaatt aaatcatcta ttttaaacgt ctcttcaaaa
     4141 aaatttaata attttaatct agaacttgtc gttccctttt tagatatatg ccaatatacc
     4201 tcaaaatctc taatatctct atttagatat ggcaacaagt catcaaaaga taagtttaca
     4261 tcataaattt ctgacatttt tataatatct tctgtttttc cactagcatc tcttaatgct
     4321 tcaaaatata tatttttcca tttttcactg agcaagatac catttatttc tttttcaaat
     4381 tcaatcttat tgcactctat attttcatct tttaagacgt ttatagctat taggaaaatt
     4441 gaatataaac tttcaaagtt agtcccataa tttactacag taggtaaaaa tcgattcact
     4501 aattctaatt tattacctat atatttaaat tctacactta gcaagtaatt gcatataaga
     4561 cgtgctaaat tatttatctt ttctttatct aaatctcgtt tttcaagata ttcattcaaa
     4621 tctacaattg aaataatata gttcatcaat aatcgttcgt actttgtatc cttataacca
     4681 tcttcaatta gataggaatt tattttagaa tctaaatttt ccatattaac aatagcaaat
     4741 acttttattg aacctgtagc ctttttagat aaattaaata aatatgtatt gtaaaattca
     4801 agttttttaa tagtattact cagataaaat acgtattctc cagatttaga aaatgtatct
     4861 acaacttctc ttaagttttc tacatttaga tatttctcac ttaaaactaa ccctagtttt
     4921 acatactcaa cttttttact cttatatatt aattctttag ttaatttata taaccatttc
     4981 tcatcaataa tcatttcttt taccaaagta tttatctttt tcataaaaat ttcgaaataa
     5041 caaattaaag acttagaatt actaccctcc aataaataaa tttcattaga ttcactttta
     5101 tacatattta aaatttcatc tactagatta tttgcaagct ctacttgttc tcttaacggt
     5161 atactttcat atatacatag gtaattcatt tcaaatgatt ctttgtatcc atcataacca
     5221 ttaaattcct gcaatcgctt aaaaacattc tccaccaaat tatcctcctt tacatgatgt
     5281 aatttatatt gattatacta cttatttcat caagtttaca tttatacgca aaaaaatatt
     5341 actagaaatt gaaattctag taatatcctt attattaatt atgtaaatac cctatcttat
     5401 aactgtaaat aatatcctta ttaattttaa ttacttttaa taaaaatcta tcctagattt
     5461 agacttctct atgcatatat tatactaata ttagacatca taatcataca ctttttcttt
     5521 ttcatatctc atgtttacaa acaatgcaag taaaattcca acaaatgtta ttgccacatt
     5581 aaacaataca acatattttg gtccattaac tccccctgat tttgtaataa tacctgctat
     5641 atttaaaata acatagtttg ctatactaga tgcaatcata actatagatg ttatttttcc
     5701 tttattagtt ggaaacattt catttgcagt tgacgttgtt aactgaagaa cacctcctgc
     5761 tgctgaataa cctattacaa atccccctaa catacaaata gttggagttt gaacaaaata
     5821 tacaactaat agcataagta aagctattat aggatatata actaatattc ttattggttt
     5881 aatatatttt ttaataagta aagaagttat taatactgca catattactc ccattgagta
     5941 aaaggattga atttttgtag ggtcagccat cccatacaat ttacccaatt cctgattaca
     6001 atttaaccat aatacaaatg tagatgtaca tgtaaatcca atacaaacaa gagctatact
     6061 tgttggtgta aatttcatct tctctgattt aactgttttg cctttgttat caataacatt
     6121 attagctggt ggaaatggta acacagctat caaaaaggca tctactacaa taagaatcgc
     6181 tgttactata aaaataactt taaatgatat tgaatttgct gcaacaaatc caattataaa
     6241 aggaagcaaa aattgtgcta aagctattgt aaatttagta aacatatttg ctattgttcc
     6301 taaactagca aatatctcca tacaagaagg agttacacag gtatctaaga atgaatttgc
     6361 tgcccctcca attattgcaa atacatatgc tatataaaaa tttggtgaaa atacaattcc
     6421 aacaaagaaa attgcatgta gaaagtttcc tataagacca cttacttttc ttccatactt
     6481 atctgaaata ggtcctgcaa atggataaga tataagtctc cctaatccta gtgcagcaat
     6541 aacagctaaa acaatactta catccaatgt tccatctgat aatgttttag ccccccacat
     6601 tgatgaaaat tctggtttgt attgtcctaa aattgaaatt ccaataccaa gtaaaaaata
     6661 tgaaaaatac aacgctatgg cagtaggata atatttttta ttgttcataa tttttctccc
     6721 attcttgtta atttattaac atttttgtgt acaataaact catccccata atggatttaa
     6781 agtatagtca gttaaagctt caaatttaac tggactatga ggcaaaaccc actatgacaa
     6841 tttgtaattt attattaaaa atattgaaat acgtatgttt tttcattgtt taagatatta
     6901 ctcttatcta tttaaagcat aattcattaa cttcttctac aggcatttct aatccagtat
     6961 atagattaaa agcttctgct ccttggtata ataacattcc taatccacca atagccttac
     7021 atccattagc ttcagcatct tcaatcattt ttgttttctt aggattataa acgacatctg
     7081 ttactactaa atcttttctt aaaacactag tatcttttat atttgtttca ttgtcataag
     7141 gcttcatacc aataagagtt gcatttgtca atatatcact tgattgtatc tcctcataaa
     7201 gtttgtttgt atcttctaaa tcatatagat taacaacaca ttctggtaca tcttttttta
     7261 tattctcaac tgtttgctct gctcttttat aaaaatcatc cttaggatta aagatagata
     7321 tttctcttgc tccatctaaa gcacattgta cttgtatagc agttgctgca ccaccagcac
     7381 ccataattgt aatcttttta cctttaactt ctaccccatt ttcttttaaa ttacgaacat
     7441 agcctactcc atctgttata tgaccaacta actttccatt gtcatttaca attgtattac
     7501 atgctccaat tatacgagct gctggagaaa gttcatccat atattctgta acagcagatt
     7561 tacatggcat agtaacattg gctcctttta tattaaaagt ttttattgct aaaagtgcct
     7621 cttttacctt atctactgtg atatcaaagg ctaaatatct ataatctaaa tctaatttct
     7681 taaaactata attatacatc actggtgatt tagagtgacc aaccggtgta cctattaatg
     7741 caaataatcc tgttctacct gaaatttcca taactataat ctcctctcaa tattatcatt
     7801 ttctttgcaa ataacctatt cagttattta caaagaaaaa tttatttatt atttatatat
     7861 ttaatgctac ttcaaaagct tcttttgttg catctaatgc cctacgagct tttactgcat
     7921 caccaacaat ataagtttct tttacaactt cttttataac ttcacttaat gggtcgtaat
     7981 tacgagaacc catagcaagt actactgaat caaaaccttt taaatcatgc tctgtgccat
     8041 ctgtaagtaa atagtcgaca ccatcatcat aaaatttaga aacttttgca ccagtaatgg
     8101 tatgtatatt ataattttca aaatcattca taaggaattt acggtgttct gaaattacat
     8161 ctgcaccaac ttcttctcta agctcaataa cagtaacctc atgttcttgt tctccaagga
     8221 aggctgccac ttcacatcca accattccac ctccaacaac aagtactttt ttcccacaag
     8281 attttttacc atcaagaagg tctacagcat gaattaatcc tgaatcattg attcctggta
     8341 taggaagtac aagtggagtt gctccagtag ctataataac tacatcaggt gatttctcct
     8401 ttataagttc tactgtagct tctgtattag tacatatttt tacaccatat tgattacatt
     8461 ttgaaatata acttctaact aagttagtaa tatctccttt ccctggagga tatgcagcta
     8521 aacgcatttg cccaccaaga acttcagatt tttcaactaa agttacatta tgtcctcttt
     8581 tagcacatac ccatgctgca agcatacctc caacacctcc accaacaaca agaacttctt
     8641 tgctaatttc agctggctta agctctgctt catgtcctaa tataggattt gcaagacagg
     8701 ctataggttt gccttggaac atatttggta cacatccttg taagcatgca atacatggta
     8761 tcatttcgtc tagttttcca tttttagctt tattaggcat ttctgggtca gccaagcttt
     8821 gtctaccgaa tgctactaaa tcacatcttc cttgtctgac cattaactca gcaaactgtg
     8881 gctctgtata acgtccaact gttattactg gtatactaac agcttttttt atttcagtaa
     8941 ctaattctgc actgaatcca gcatgtaaag tcgtaggagc ccacatatat tcatcatgta
     9001 tatgtatact acgtgaaaca tgaagtccat ctattccaca atcttctaga tatgctgcta
     9061 ttactgaact atcgtgtaca tcaattcctc ctggaacatc atcagtgctg tttatacgac
     9121 ataatattgc tagagaattt cctacttttt tacgtatatt ttcaatgata agacgaggta
     9181 atctcattct attttcaaaa catccaccaa actcatctac acgcttattt gttctttgtg
     9241 atataaaact actaaccaga tatccatgag cgcagtgaac ttcaacagca tctgcaccag
     9301 ctttttgtgc acgtaatgca gcatctccat aagattctat aagttcatat atttcttctg
     9361 ttgttattgc tagtggtgta ttacgaccat ttgatgcagg tattgcagaa gcagctttta
     9421 atggatgtcc tgctactttt tcatttcctt cagaaccagc atgttgtaat tgtatagata
     9481 ccttcgaacc tgcatcatga caagcatcta ttacattttt aaaactatct attgtgctat
     9541 catcatataa acaaggctta cgaggacctc cttttgcttt tttgtctaca acactagatt
     9601 ctatagttat taatccaaaa ccacctaaag cacgctcaag ataataagcc ttagaagttt
     9661 cacttaaagt accatctgtg tttgcaaaat tgtttcccat agggggaact acaaaacgat
     9721 ttggaactgt cattgaacca attcttatag gtgtaaacat agaactaatc ttcataaggt
     9781 tttccttcct ttcaagtttt atattataat actctgtata tttttatatt atataagttt
     9841 attttggaga tacttcagac catgctttat ccaaaacttt tttagttgca ttaaatacag
     9901 tttcagcagc agtggataac cctttagata ttagagaatc agatattact tctgccccta
     9961 tgactcttgg tgatatattg tgttctttta ttattttcac aaattcctct gtgtttccat
    10021 atccttcacc tggagccaaa cggtcatgta gtgattcatc cctaagtttt tcataaggag
    10081 tttctaaaac atcacacact tgaattgata ctatcttatc tgctggaaca ggtgcaaggt
    10141 cctctgctgt ctgctttgct ctagcccagt gccaagtatc taatataagc attgcatttt
    10201 cacgattaca tcctttcaca acacgccatg cagtagccaa atctggtaca ccactatatg
    10261 gcataaactc aagacctata ataagttcac ctgctctgtc acataattct cccaatgcag
    10321 ttataatttg ttcttctggt atcatctcta ataatccaca atttatatgt ttaacattaa
    10381 ataagtgagc catatgataa acattttgct ctttttctct ttgagcttcc gttctatctt
    10441 cttctcttcc ccattgagtt atatattcta cttctgtaac tttcatatca tattcattaa
    10501 gaattgcaat catttcttca tctgtaacac ctgcattttt tgcatcaata taattttcag
    10561 cacgcaatcc aataccatca aacccagctt cttttgcaat acgaactcta tcacggaatg
    10621 aaacttctgt tcccaatgta taagaactaa ttgtaattgg aatattaaga tttttttgat
    10681 tattcatagc ttaaatttgc cccctttatt ttctttataa ttaatagtat ttttgatttt
    10741 atatttttat ttatcctact agtagtatta ttttacctta aaaataaaag tattttttga
    10801 tttctattta tctagatttt ataaatttat tgtatcacga gactttacta ataacaaatt
    10861 gataatttcc tattaattca tagattttgt ttatagattt tatttataag ataattcttg
    10921 tatttttcta ttaggtcgta taaatatatt tatcttataa ttcagacaaa aaacgataaa
    10981 tttttttaaa agcttttatt cttactctat aatcatatat aataaaaatg taaaaatatc
    11041 ttaaaggtta acttctacaa atatataaat aaaaatacct atgaaaggat gaacaaaaat
    11101 tgaatttata tcacttacgc tattttgtta cattggcaca tttagaacac tatacaaaag
    11161 cggcagaaaa tttatctata acacaaccaa gcttaagtca tgctatttct ttactagaaa
    11221 atgaacttgg ggtggctcta tttgaaaaag aaggtagaaa tatagtcctt actaagtatg
    11281 gaaaaatatt tttaaaagat gtggaaaaat cattagaaat tttagattca agtgtaaaat
    11341 cattaaaaat aactggtact ggtgaaggac aaatagactt agcttttctt agaacacttg
    11401 gtactgattt tatcccagac atagtgcaca aatttttaaa atctaatcct gctaaatcaa
    11461 tagattttaa atttcatact ggtgtaacta ctgacattat tcaaggtctt aaagaaagaa
    11521 aatatgatat tgcattttgt tcgaaacttg aaaaagaaaa gggaattgaa tttatacctg
    11581 ttgccaaaca agatttagta ctaattgtac catatagtca tccactagct gcaaaggata
    11641 ctatagattt aaaagaaacc ataccttatc ctcaaatagt atttaatcag agaagtggtc
    11701 ttagatatat aattgatgat atgtttaaaa aaataaatca acagcctaat atagtctatg
    11761 aagtagagga agaccaagta attgctggat tagttgcaaa aaatttcgga attgctgtag
    11821 tcccaaatat gaatatgctt agctttacaa aagtaaaagt aattcagatt attcacccaa
    11881 gttgggaaag aaacttttac ttagcattta taaaagatag atatttgcct cctgcaatta
    11941 aaaactttaa aaactttgtc attaaaaacg ctcaattata atttattaat aaaggggtta
    12001 tttttaaata tcctctttta ttctttttat aaaataaaaa aatctatact tttaaaagta
    12061 tagattccta actgacagtc ggcatccgag tctcagtaat tatcgttata caacagcaac
    12121 tggattcagt tcctgaataa ctaggttact tacattatat cagatttttt aaaatttgtc
    12181 aattgtatct aacgcatttt ttcaagccat ggtccaacag gctctacaat aggaacttct
    12241 ttaaatcccc aatttcttat atcattcaca ctcgttggag tatatatttt gtttctgaca
    12301 gatttgaata ttttgttttt ttctccatat tgcatacact ttggattagc ttctattaac
    12361 cctcttcttg ctctgctaag aggattacat aaaatatctg ctatttctaa accttctcta
    12421 tagtcagcat cttctttttt ggcaattata aaacccttaa ccttatctct taattcttca
    12481 tctatatcta agtatattgt tccattatta aatacatcaa aaaacgcctt ttgtactttt
    12541 aagtttgaga catcatccct tgactctata actattcgtg cagattctac agtttcatta
    12601 tttacaaatg aataaaaatt ctgaagaaca tgtataaaag ccacaacata cggttccttt
    12661 gaaggtgcat aatatttctt taatctagct ttatctactg ttactgatat tatagtacac
    12721 tctaatctag atagaaataa aggcaactca tcatagaata acttaatctg tgaatcatca
    12781 aacttctcaa atgctcttga ttttcttgat atatctgtca aatgtattcc tatgttactg
    12841 gttccaaaac aatactcttt aaatgcatcc atttctttcc tcaaagaaca tacataatcg
    12901 ccttgactta ctgcatattt atattcaaaa attactcctg tcaatgtaaa tgggtcttca
    12961 tgatttatat cagctcttcc actttcatca ataaacatta tatatttttt ctttataatc
    13021 ttactcaccc tcttaacata tgatgatagc atctatattc attttatatg agttttaaaa
    13081 atattccaag atttttatat aacttaaact taattttata ctaaaaaatt gagatgtaaa
    13141 acaatcaagc ttttattgat tgaatttcac atctcaatta taattatttt tcaatatata
    13201 tttttactat tttgcaagaa tatccattaa tttatccatt actatataag atactccgcc
    13261 tcctatttga taaggagttt caactttttt atttgcaaat actctttgtt gctctgatga
    13321 taatcctgaa ttatccatta aaactattgg tgaatgtaat tttacagcta atggtccagc
    13381 tgataaagca tctactaaag catctgattt actaactaat acagcctgta aatcagtatc
    13441 tccatagaat ttttctatca ctttggcatt agtatctact ctactatctc catatattct
    13501 atttcctgaa atatcttcag tagttatatc attcattttt gctattactg aatcgttaat
    13561 tgcacttggt ccacctataa agtatgcatt ttctaatttt ctttctgtta gccatttata
    13621 agattcttct gtaattccat ctttattgac taatattata ggttgttttt cttccccagc
    13681 tttagaagct acagataaag catctgcctc cccatttcca gaaaccatat atgcagtttt
    13741 tatttcttct cgatttccaa gttcttcagc tattcttgta gcagtttgat atctatcttg
    13801 acctgctatt ctctttgttt ctgtgttgaa agtagttttt atttcttgct ctaatttaga
    13861 acttattgca ttttctccac ctatcaagat tactgtttta ggtgctaata acttcatttc
    13921 ttcaacagtt tcagttggta aattagctgt attagtaagt agtattgttg agtcatagct
    13981 acttgctaaa ggagttgctg ttataccatc agctattgca ttaccattta ctaatattac
    14041 agtatctgaa ctatcagcat tccagtttcc aactgaactt atctttttag ctgtatcaaa
    14101 tctatttgca cctataattg tatcccatgt aggatttata gttccatctt cattaaaagt
    14161 ataatctttc ccatctattt tttgagaacc agttagcatc tttccatctt tgtctaaata
    14221 gtaagactta ccatctattt gttgccatcc tgtctgcatt attcctgttt tgtcaaagta
    14281 atacttatta ccatctattt cttgccatcc tgttactgct aaaccatcag atcctagata
    14341 gtatttcttt ccattctttt cttgccatcc tgtttgcatt actccatctg agttaaagta
    14401 ataagttttt ccgtctatta ctttccatcc agatactctt gctccatcag ttcctaaata
    14461 atattttttg ttattaattg ttttccatcc tgtttgcatt actcctgaag catcaaagta
    14521 atacattttt ccatttactt ttagccaact attcttttgg tatgttccat cagattttac
    14581 ataatacttc ttaccatttt ctgttttcca tcctgtttga tttagattta tcttatattt
    14641 tgccgctatc tttacatagc tgtcgttact ataatctata attacatctg aacctacagg
    14701 aacttggtca aataaccatc taacatcttt attgtgcatt cttatacatc caccagaaat
    14761 atgctttcct atagaactct cattattatt tccatgtatt ccatatgtat ctccataagt
    14821 tccttttaat gctaatccca tccatctatc tcctaatgga tttcttggac ttcctccagg
    14881 tatattacct ttataatatg gtctattttt tatcttgtta actacttttg ttttccctgt
    14941 tggtgtttct gacccctttt tacctgttgc aactctaaat tcttttacaa gtttattatt
    15001 tacaaaatat cctagagtat tttttcttga atttactata atcacatgtt tactggctgc
    15061 gcttgattct ggtacgccac atgcaaatac taaaactaaa gtcagtgcta gtactaaata
    15121 cttttttaga ctttttttca ctataacttc cccctctttt agaaacatta ctacatgtgt
    15181 ctaattataa cataaaatta ccaatacctt atatttacaa atttgttaca tttatacata
    15241 taagtatgta ttctactctt catacccatt aggattcata ctttgccatc tccatgaatc
    15301 ttcacacatc tcttcaagtt catacttagc tttccatcca agctcttttt ctgcctttga
    15361 agaatctgca taacacatgg ctacatctcc agcccttctt cctacaatct tatatggtat
    15421 ttcttttcca cttgctttag aaaatgcttt tactaaatca agaacactat acccctttcc
    15481 agttcctaaa ttataaacaa caagtcctgg attttcttct aatttttgta atgcttttac
    15541 atgaccagca gctaaatcta atacatgtat atagtctcta actccagttc catcatgtgt
    15601 tggatagtca ttaccataaa cactcaattc cttcaattta cctactgcta tttttgttat
    15661 ataaggcatt agattgctcg gaactccatt tggttcttca cctattctac cacttttatg
    15721 agcaccgact ggattaaagt atcttaaaag agctatatcc aatgacttat ctgcttttga
    15781 tatatctact aacatctgct ctatcataag tttagttctt ccatatggat tggttacaga
    15841 aagtggaaaa tcctctaata taggacaagt atgtgggtct ccatatacag tagctgaaga
    15901 actaaataca aactttttaa caccatattc tctcattaat tcaaataaat ttaaggtact
    15961 tattagatta ttgctgtaat attcaattgg tttttctact gattcaccaa ctgcttttaa
    16021 agctgcaaag tgtataattg attcaatatt attttcttta aatacaacat gcatttcatc
    16081 tttatttctg atatcaatat tataaaattt tactggtttt ttagataatt ccttgattct
    16141 atcaaccact attgagttgc tattacttaa gttatcaact ataacaactt cataacctga
    16201 ttctaaaagt tctattgctg tatggcttcc tatatatcct gctcctccag ctactaaaac
    16261 tgccattgta attacctctt ttctaatatt tatttttcac ttactttttt tctcatatag
    16321 tccattaaat catcttttaa attttctctc tttagagcaa agtctattgt tgcctctaaa
    16381 aaaccaattt tatctcccac atcatatctt ctaccttcaa agttataagc ataaatagcc
    16441 tcttgttttc caagagtttg aagtgcatct gtcagttgta tctctccacc tttaccaggt
    16501 gtctgtttct ctaatatgct aaatattgca ggagttatta tatatcttcc aagtatagct
    16561 atatcagatg gagcttcttc aattgcaggt ttttcaacca tatctttaac tttatatact
    16621 ctatcttcga tatgttttac atccaatata ccatatttat tagtatcttc tttagctatc
    16681 ttttgaacac ctaatacagt tgttttatac tcattataag tatctattaa ttgttttaag
    16741 cacggaacat ctgaatctac tatatcatca cctaataata cggcaaaagg ttcatcacct
    16801 ataaaacttt ttgcacagta aattgcatgt ccaagacctt ttggctcttt ttgtcttata
    16861 taatgaatat ttaccatatt tgatatgtct cttaccattt ctaacatctc tgtcttacct
    16921 ttttgctcta gttctaactc taattcaact gatttatcaa aatgatcttc tatagatttt
    16981 ttatttctac ctgttattat aagaatttct tcaattcccg attctatagc ttcttctatt
    17041 atatactgta aagttggttt atctactata ggaagcattt ctttgggctg tgattttgtt
    17101 gctggtaaaa atctagttcc tagccctgct gctggtatta ttgctttttt aactgtcatc
    17161 tgcatttttt cacccttctt cgtaaatttt ctattgtacc aaattaatat accatattta
    17221 tactttttct tcaaactcta tattatccca atatttaatg ctataagata atataaggta
    17281 gatgaaattt catctacctt tagttttata agttaatatt gtattgttta tattttatcc
    17341 aaaacttata caggtactaa atttcatcta agatgccttt tatatcacta tctatatctt
    17401 catctagata agaatctaaa tcttctaagt caacttctag ttcttgatat gtcatatcaa
    17461 cactgacatc ctcatctata tccatttctg atattaattc tcctaaaata ctatttccat
    17521 cagaatctaa accactatct atatcttcat ctatatagtt ttcatttaaa atttcatcta
    17581 aatcaatctc gtaataaact tcattatttt tttcatcccc tgagtccaat cctaagaact
    17641 catagttaaa agtccaaaca ttgtatttac ttgacatact ttattcctcc tgtgaaaaac
    17701 atattttcat ctagtttatt ggttccataa tcaacagagt tatatatttt ttcaattatg
    17761 tcttttcttc tttcttttgt actattattt aatgtcaatt gtttaaatac atatgtattt
    17821 gttattctct cgaataatat ttcttttata ctatcatcat caatatttct atagtttttc
    17881 cacaataact caaataactt aaacatttcc ctactagttt catctacata ataaggatac
    17941 atattttcta ctaaatggtt taatcttgat atggcttgtt ttaaaaatac atcaagactt
    18001 gcactttcac tttcttttaa cattctataa ttgtatttct tcttatcttc tcctgaaatt
    18061 acaaagatga tattgtctaa acttttttca acttcattta aataactgct tatattatat
    18121 gataaatcag acaatagatt tttaatctgc ttaaacactt gtacatcaag tttagtatta
    18181 tacttttcaa acaaatctat ttcttgattt tctaatattc ttggcatata tgctgacaat
    18241 aaatctaaat tgtttctttg ttcttgtatt tgcttataaa gtgaatttat aacttctatt
    18301 cttatttcat catttaactc tttttctaaa atcttatcaa attcagattt catatagtaa
    18361 atatttccaa agaaattaaa tattatcata tcattcatag ctttagacca attcttatat
    18421 atcacttcaa tagaattttc tttaagtaga ggttgctttg catatataaa tacatcttgc
    18481 ataagttttt gaaccatact tttacttaag tttaaaagta ctttttgatt attaaatttt
    18541 atttccgttt ctacaaaatt agaattttcg ttttcaagtt ctttattaat tacaatgtct
    18601 tttatatcac tattttttat agatatgatt tctttttgaa aagactttag aatagtcaag
    18661 ctatcgaaat cttcttgaat aaaaaatgga gcatgtttta atgtatatcc cactatttca
    18721 ttttctatat cttttaggtc atctatttgc ataatttctc tatttttatc atttatatgt
    18781 aggttaaata catttttatt atcatataat attatatctt ctcctaaatt taacttagaa
    18841 caattatctt tcgctgactt tacaatagtc ttcttagatt tcttatttat aaaaattaat
    18901 tggtcttgat attttactaa aagcatgttt gtgtttttat aatcaaatcc atctatattt
    18961 cctgatatct tgcagaatac tatttcacaa tctttaggaa gatttcctat tttttggtta
    19021 tctttaactc tctcatttaa atcagatggg actacactat ctatattgtt attaaatata
    19081 gatacagacc ttactataat cccctctctt tccatatgaa agtatccctt caatgacact
    19141 cttttatctt ctaaaatgta tctttctata tcatcaaaat ttatttcaaa tctatttttc
    19201 ccactgataa atataaactt ctcattatct ttattaattc cacccatata aaacttattg
    19261 tcatctaaac ttaatatagt catattatcc tttagataga atataaattc tctttgactt
    19321 ttgcagatta aatcatattc atccaaagtt attttcatag tcaaatttgc tgtaacattt
    19381 ttacttgaat tttcactttt tatgtaaaaa ggcaagttat ttccatagac aattatttga
    19441 gaatcttcta aaactgcctc taatttttct ttattgtctg aaaaactata tatatatttt
    19501 acacctgtat cctcattaac ttcatctgat ttgctgatta ttatattccc tagatttgtt
    19561 atatgaagct ttttatattc ttttgagtat ctacttatgc cactaagctc aaacccatct
    19621 gaaagctcat atatgatttt ttctcctaat ttcaacatac cttcaccacc taaacagaat
    19681 tataagtatt ttataaaggt gaataaaatg tctcaaaaca aataatattt tttttaatac
    19741 tttttattct gagacatagt ttctcctttt ttataatgct ctaagcacct tcaactattt
    19801 cttcataaag tttatctaaa tgtttaacat attcacgata tccagatttg ttctttaact
    19861 cacttcttaa atcttcatat ttttgtttaa gttcttcagc actcaaagaa ggagctgatt
    19921 cttttaattc ttctaactta taatcatagt acttatcata catagctata tatgtatcaa
    19981 tagacttctt agctagttca ttacattttt cttgtgcttc tccatattga gaataatcac
    20041 ctatttttat tttatagtat ccattttctt gaattattgt tgaagaaata cctttagctt
    20101 catattcttt tgctgtttct tttgctgttt tttcaacttt aagtgaacct gcataaacag
    20161 tgtaatatac acctttacca tctttatatg cttccatttc ttttgctttc ttttcagctt
    20221 gtgctttttc ttgagcctct ttttcagctt ttgccttttc ttctgcttct tttttctctt
    20281 tttcagcttg tgcttttttc tcttcttcag ttaatttatt gttagcttgt tgttgagttg
    20341 atgactttgg aatattctct ttatcatttt tcttattgtt gcctactgtt ataaaatatc
    20401 ctacaccaac aataaccact ataactactg ctataatagt ttcttttaat ctactcttct
    20461 tagaaacaac ctcttcatca tctaaagaat cttctttatc tgatacataa tttttcattt
    20521 ctttcttgtt ttctctatat ttgtccttag aagaattttt agatttttta ttactatttt
    20581 ctttcttttt aataggtatt actactgatt tttcattttc taatttttct tcttttattt
    20641 cttttgcttt tttatcttct aagtttttac tttctttttc aagcttcgat tcattatttg
    20701 aagatacttt ttcatctaag ttattattta ttggtttttc tatttttaca ctacgttctt
    20761 cttctatatg ttgacttggt tcttcttgtt ttatttcttt caattcattt tgctctattt
    20821 cttctgattt cacttgatga ttttcaactg gtttatctaa aattatatct ggagaaatat
    20881 catttaaatt ctcttcttct tgttcagctt cttcattgtc ttttttaata aatccaaata
    20941 atttagcctt ctttttactc tttttatttt ctggttcaat tatatcttct ttattgctgt
    21001 cgtactcttt atctgtagta tctttatctt ctacaacgtc acctatatct tgattattac
    21061 tatctacttc ttctttagtc ccttcttcag catcatcttc tattgaaata ctacttctaa
    21121 agcaaatatc tttatctgca ttttttatca tgtaaatgta ttcttcaata tcgatatctt
    21181 tatttcttct agttcttttt gatgcaattt catgattttc taattcacta tagttatctt
    21241 ttattagatt ctgtgcttta ttccatgtat cttcactaat ttctgtttta tttttaatta
    21301 catagtccac aaattcctta aaattttcag gaccaaattc tccaattata gtcagtctca
    21361 ttgcaccttc tataaggtct ctatttcttc tctttaaaaa ttctaataca actgttgcac
    21421 aagcaaaatc tttaataatt tctttgccaa aaccatatgc ttcaacagaa tgaagttctt
    21481 ctaatccaca taacttctta tattcattgt gtattgtttg agatatactt tcattattta
    21541 agctatttaa cttatctata aacttcgatt ctatatcatt tgattttgat tcatgtttta
    21601 cttttgaatt tttaatttca tttagtagca tgtcattttc tgaattatct ttacctaatt
    21661 gcaaatcctc aatttcagtt gcttttattt ctactttgtt ttgttcgtta ttctcttcca
    21721 cattattagg taccacatct ttattactag ctaatatttt gtttacacag aatataattt
    21781 ctctttttaa ttctcttttc gcatctgctt gatttttaag aaataaatct ccacattctt
    21841 tcttttctaa acttattttt ctaagagata tattaagaag gtctttatat aggtttaaaa
    21901 ccttataatc cttttctaaa cgtcttcttc tctctgatag ttccatttta tcataagcta
    21961 aaaaactatt taaatcattg gcttttagag agtctaatcc ctctttcata gccttattta
    22021 catactttct acattttgct gtagttaact ctaaatcttt ttctaattca tctatttcag
    22081 gtatgtactt atctactatc catttgccaa taagtggttc tgtatttctt gctaatgtct
    22141 tataaaacaa tatattaaat tttaaaagct ctgcatattt tgcttcatta aattctactt
    22201 tttcaaattt cttttccaaa acaccatcta gcttttcatt tattttagac tcttgtttta
    22261 aaaaacttgc tgtgacattt aaaacagtgt ttcttattat attattttca ctcaaaacct
    22321 tcactcctta aatcaattat tttattgtaa tatttacatt gtgcaaagtt gctaatttga
    22381 ttatgatatc taaataatta tttactaaat ttgctacatc ttatatcata tcatattatt
    22441 tacatcattt tactttttct ttttatatct atcttatatt ataccatttt taatatctgt
    22501 actaacttat attacaatat tcctcaaaat tttaaaagta gattagacaa atttacaaat
    22561 aaaaaaacat cagtttaaac tgatgttttt gactatcgaa ataattaagc aagtctataa
    22621 gcggagttct gtattagata atcatctttc taggcctatt gtcaccaata ggctcaagcg
    22681 acctacctac cggagagtac gagcagcact ctttattcct atcttggtct tgctccaggt
    22741 ggggtttaca tagccaacta gtcgcctagc tgctggtgag ctcttacctc gcctttccat
    22801 ccttaccaca atagtggcgg tttatttctg ttgcactatc cttaggatcg ctcccactag
    22861 gcgttaccta gcaccctgct ctatggagct ccgactttcc tcatgtaaga ttacatgcga
    22921 ttatctggct tacttaatat ttattttact tagttatgtt aacacaaatt cttttacatg
    22981 tcaaagtaat attatactaa aaatttaaat ttattcaaaa atagtgtaat atagatatat
    23041 aaactacatt taactcgagg tgatctattg aaaaaattat atagaatagt aattaacatt
    23101 atactagtat tagtaatact ttacagtgga tttaatatat actcaaaact taccaaatac
    23161 aatcatgata ctaaaatatc ctcagaactt caaaaaaaag aatataaaaa agaggattta
    23221 tcaaagatta acagtgattt taaattttgg ctttctgttg agaatacaaa tataaattat
    23281 ccagttgtac aatctaaaga taattcttac tatcttgaca aagattttta taaaaaagat
    23341 tctatttctg gtacactgtt tatggattat agaaataaat ctattgatga caaaaatatc
    23401 ataatatatg gacataatat gaaaaataaa actatgttca acaacctaaa taagtttaaa
    23461 gatgctgact tctttaaaaa aaataataaa ataaaaataa ccttgaatgg aaaagaattt
    23521 ttatatgatg ttttttctgc ttatattgta gaatctgatt atgattatct aaaaacaaat
    23581 tttaacaatg aatctgatta tcaaaattac ataaatgata ttacttctaa atcattgtat
    23641 aaatctccta ttaaggtaaa tagcaatgat aaaatagtta cactttctac atgtacctat
    23701 gaatttgatg atgccagaat ggtgattcat ggtagattga tttaaaactc acagacacag
    23761 tttaaaacaa taattttaaa ctgtgtcatc ttttatacct ataatttgta aattagacca
    23821 ctaaaagtat ttaatacaaa ataacaaata catcaaacaa taaaaaacaa taaaaaaaga
    23881 ctatgctaaa aacatagtct ttactggagc tggtgatagg aatcgaacct acaacctgct
    23941 gattacaagt cagctgctct accgttgagc cacaccagca cacctatttt attgtaaatt
    24001 agcaaaacta atttttaaaa gtta
//
LOCUS       DAEHWM010000061        23643 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.062, whole genome shotgun sequence.
ACCESSION   DAEHWM010000061 DAEHWM010000000
VERSION     DAEHWM010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23643)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23643)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23643
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.062"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            191..1213
                     /locus_tag="KNP36_002416"
     CDS             191..1213
                     /locus_tag="KNP36_002416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874279.1"
                     /translation="MVNWEIKKLAKSKSMFISLGILVLILMISIFITPVLETESYYID
                     KEKGRIEDTRSGIDVGNEKFQNKINVLKQFSNQTDTGEFSKKIELMSKKKLDNLSVNE
                     YKDISFWKVFNYRVTNSLINVGMLIIISIIISNIYVDEVVTSVKDIILSSKEKKKALK
                     SKIFVALLVPLVIYSVYLMGIFIITCMQQGVPVNGDLESFRIVDNVVALKTNLSITKY
                     VILNIGIELLMFEGWAMIAIFGSFISKSSISSISFFIFIISITKIMSVIHILPKKLLS
                     VVSNVNYYDLIFGFNKIIGNYLGDIMIFKVNIDIVNIAIGLLMAILIGAMSLCFLVIK
                     SDYISR"
     gene            1227..2114
                     /locus_tag="KNP36_002417"
     CDS             1227..2114
                     /locus_tag="KNP36_002417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874280.1"
                     /translation="MNKLEIENLSKIYGKKVANDKITVTLENGVYGLLGPNGAGKSTL
                     MKQITTLIKPDEGQILYNGEDIFKMDADYRNILGYLPQEFGVYKNFTAKEFLQYIGAL
                     KGLRGKYLNSKIGELLDLVGLYDVRNKSIGKFSGGMKRRVGIAQVLLNDPKIIVLDEP
                     TAGLDPQERARFRNLIAKMSRDKIIILSTHIISDIESVAKETIMIKDGKLLMKGTHKD
                     ILSHMENKVYNVQVKNECEVDDIQSKYKVVSIQSDIDSVVLRIVSEDIPSEDNIQPVQ
                     AKFEDVYMFYFDLEDAREV"
     gene            2120..2893
                     /locus_tag="KNP36_002418"
     CDS             2120..2893
                     /locus_tag="KNP36_002418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874281.1"
                     /translation="MMYLVKAEMIKILKSKSVWIIWLFLIFFGFFLIRKFDVLDTYAD
                     IFYKIEGSIPLIGLIMFIITSGNYIKEYDSNMTGLINTTKKGKKSVVLSKLVANGLIL
                     SIINISFILLVGIRGFSFFDFKNLNESIHNLWYFGNSNLNLTVIQMYIIVILTTIFAS
                     FIFAQIGLTLSSIFKSAVIPFILGGLIMAIPYFSVGFIPDKAIKFMSVTPNWIMMSQQ
                     MVKYNVPSILIVFSIVISIILMIVLTKITYENFTSSKRF"
     gene            3005..3730
                     /locus_tag="KNP36_002419"
     CDS             3005..3730
                     /locus_tag="KNP36_002419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012450879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874282.1"
                     /translation="MENRVLIIDDEVEILKLLETVLKKEGLNNIYTAKTKKEGLELFK
                     SINPDLIVLDIMLPDGEGYDICKEIRKTSNSPIIFLSAKTEELDKLLGLAIGGDDYVT
                     KPFSPKEVAFRVKAHLRRLSYFSDAQNESKNLNNNEEKIISFGPYILNESRAELIKDG
                     KSIGLSAKELKILSLFAHNQNQIISKEKLWDKVWGEDYVGFDNTIMVHIRKIREKLED
                     NPSKPEYILTIKGLGYKLAVKED"
     gene            3734..5137
                     /locus_tag="KNP36_002420"
     CDS             3734..5137
                     /locus_tag="KNP36_002420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874283.1"
                     /translation="MKWKITRNFIFTIVFVAISVVIINIISILYVISTNSFFKVVDSG
                     NNPEEFARSFEKDLYEKDGEFKLSKIGAEKLEKSNSWIQVLNDLGEEVYGVNVPKDTP
                     KKYTPFQMVNNYKYIETKYVNFVLEKYLNKKHLNIIVGIPSRDISRIILTYSQNNIKK
                     TLNKVIIITLVIDSVVALGVGYLFSRKLTKPISSVLWSIETMANGNYSLYLKDRGIYE
                     EVFKNINMLADTLRVNEVERKENEELREEWLANITHDIKTPLASIQGYAEIINDKDYE
                     FEEDEIQEYTEIIYNKSKYIKDLVDDLNLSTRLKNNTIVLDKKKINLVSLVRDIIIDI
                     LNDNRYKNRNIEFESNEDLIEVYVDSILFRRAITNLIFNSIVHNSEGTLISVEIVKKD
                     NIEIIIKDDGIGISKSDLKHIFKKYYRGTNTGEMHKGSGLGMAISKEIIEIHKGKIYV
                     SSEIGIGTKIIIEIKQN"
     gene            5148..5972
                     /locus_tag="KNP36_002421"
     CDS             5148..5972
                     /locus_tag="KNP36_002421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraX"
                     /protein_id="HBF0874284.1"
                     /translation="MDFFKKGISGFTIKILALIFMTFDHIAAFMPQTMQIPIWFHWVG
                     RISAPLFIFMAVEGFYHTSNRKKYISRLYIWSVIMAIGNQIINNVFSHPEGAIIINNT
                     FSTLFLIAIYLQAIEFIKKFRKEKEIKYFIIGLLMIIIPIILGIFTVALLFKVTNRVI
                     ALFMILVPVPFLVEGGPIWIILGIIFYLCRGKKFSLSICYVLMCIFIFTTMSNGDYSL
                     KNSILQNYQWMMIASLPLMLLYNGEKGKSMKYLFYLYYPIHVYILYILGIYLINGF"
     gene            complement(6297..6917)
                     /locus_tag="KNP36_002422"
     CDS             complement(6297..6917)
                     /locus_tag="KNP36_002422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0874285.1"
                     /translation="MKVLLINGSPNQYGCTYTALNEITKVLSKHDIKTEILYLGKETI
                     PGCISCASCFETGKCIRNDKVNELIEDLDNIDGIIIGSPVYFSSATGQLTSFLDRLFF
                     IAGSRMATKLGASVVSCRRGGASATFDQLNKYFSISNMPIVSSQYWNQVHGFTPEDVM
                     KDEEGLQTMRTLGENMAWLLKCISAGKKAGIKEPQYEETIMTNFIK"
     gene            7183..7515
                     /locus_tag="KNP36_002423"
     CDS             7183..7515
                     /locus_tag="KNP36_002423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874286.1"
                     /translation="MSIDCISNTDLSETGFSYTLSLISGKYKMIILYCLVEFEVVRYN
                     ALKRYINTISYKTLSLSLKELEADNLIIRTEYPQIPPKVEYSLSERGKSLIPILDAMC
                     EWGERNRP"
     gene            complement(7635..8276)
                     /gene="pcp"
                     /locus_tag="KNP36_002424"
     CDS             complement(7635..8276)
                     /gene="pcp"
                     /locus_tag="KNP36_002424"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HBF0874287.1"
                     /translation="MKILLTGFDPFGGEPINPAQEAVERVNNNINGAEIIKITIPTVM
                     TKSVEAIDKAIQEHNPDIVISVGQAGGRFDITPERVAINIDDFRIKDNEGNQVIDTII
                     KEDGEPAYFSKLPVKAMVKHMNENKIPASVSNTAGTFVCNHVMYGILYMIDKKYPNIR
                     GGFIHIPYTTSQVIDKKNTPFMSLEEIVKGLELAIEACIIYKEDVKEIGGEIS"
     gene            complement(8297..9229)
                     /locus_tag="KNP36_002425"
     CDS             complement(8297..9229)
                     /locus_tag="KNP36_002425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HBF0874288.1"
                     /translation="MQNFINISLEIFYALMGFLMIVIAYKSFTTINNNKKYGTSLFWI
                     LISLPFIFGRLIPANIIGIILILSSLLTLSKQVVFAKYEEPDENFGKEQADKLKNKIF
                     IPSLILAFAAVVVAMSLSNFDNSSQFAIGVGSIIALISALIITKAKPATSVQDGSRLL
                     QQMGPASMLPQLLVALGALFTQAGVGEVISTMISGVVPADSRLFGVIAYVLGMVIFTM
                     IMGNAFAAFSVITAGIGIPFVLSQGGNPAIIGALALTAGYCGTLLTPMAANFNIVPAA
                     LLECKNDYIVIKYQAPVALVLIIAHILVMYFLGF"
     gene            complement(9251..9916)
                     /locus_tag="KNP36_002426"
     CDS             complement(9251..9916)
                     /locus_tag="KNP36_002426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HBF0874289.1"
                     /translation="MIKLIGILIVVIGFILKIDTLFTVLLAGVATGIVAGLDFNQIFT
                     ILGDSFVSNRGVSLFILTLPVIGVLERYGLRQRAVSLIEKLKRLTTGKVLTIYMIARQ
                     IAGALSIRMSGHPQFVRPLVNPMAQAAGLSNSDELKESDEEAIKALSAASENYGNFYG
                     QNLFAGSSGVLLIASTLTQFGYNVTGLNIVKASTIMAVIALVVATIQFTLYDKKLNKS
                     HKK"
     gene            complement(10488..10964)
                     /locus_tag="KNP36_002427"
     CDS             complement(10488..10964)
                     /locus_tag="KNP36_002427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin domain-containing protein"
                     /protein_id="HBF0874290.1"
                     /translation="MNTIIIYSSKYGCTKDCANILKNKLSDNVTIVDINNNNNKIELS
                     KFDKIIIGSSIYVGSVSKKIQVLCNDNVELLNKKQVGIFLCCGFSEQADKYLKSNFPS
                     SLLESANAIGIFGSEARLEKMKFLDKLIMKAVSKGNYDSFRISQDNIDNFLINLNS"
     gene            complement(10967..11371)
                     /locus_tag="KNP36_002428"
     CDS             complement(10967..11371)
                     /locus_tag="KNP36_002428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FMN-binding protein"
                     /protein_id="HBF0874291.1"
                     /translation="MKIRNKATNKKKKYVKISIALFFVFICIIIVIVSNLKPENLVVK
                     DIDINNVKNGIYTGSADNNLVKATVSVEVNNGKIQNINILKHDHLLGKPAEKITTSII
                     KQQSLDVDAITSATYSSNTIRKAVENALRKGE"
     gene            complement(11346..11975)
                     /locus_tag="KNP36_002429"
     CDS             complement(11346..11975)
                     /locus_tag="KNP36_002429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0874292.1"
                     /translation="MSIKERRKNEKEEMKKKIMDASIEIINQHGYENLSIRKIATKIE
                     YSPTTIYLYYKDKAEIISDMTNKLYNTVESNAIDIMNNCSSLPIDKQIIEIMTSFIKT
                     LSSEPEMAKSIMHSRMNIIFASENTNNTPSNNGIKMLDKFLSIGIEQGIFKKNIDKSS
                     WMLISALLGFVLCVVENKLYSLHNFSQLIENFLDILVGGLYNENSQQGY"
     regulatory      12341..12384
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00522"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF00522"
     gene            12485..13453
                     /locus_tag="KNP36_002430"
     CDS             12485..13453
                     /locus_tag="KNP36_002430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside hydrolase"
                     /protein_id="HBF0874293.1"
                     /translation="MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPAN
                     IGAENALKTLQMCSSLNIPVYIGEEAPLKRKLVTAQDTHGEDGIGENFYQKVVGAKAK
                     NGAVDFIINTLYNHEKVSIIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNC
                     SPVAEFNYWVDPHGADYVYKNLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYI
                     TEITRFYIDFHWEQEGIIGCVINDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIV
                     DSFNFYKKNPNAIVLNEVDEKKFMYMFLKRLFKGYEDIIDSVEGVI"
     gene            13455..14018
                     /locus_tag="KNP36_002431"
     CDS             13455..14018
                     /locus_tag="KNP36_002431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HBF0874294.1"
                     /translation="MKRKICVKTITLIAFGISINIIGAFIAMGLRLPVYLDSIGTIMI
                     ASLLGPKYAVVTGVFGSLISGITFDVYSLYFAPVQISTGLLAGIAFKKNFLRGLKTPL
                     GVLLFAIPTSIISSIISAFLFGGMTSSGSSYIVQILKVLGLGDVFSVFVTQVFTDYGD
                     KLLAVVLVNLGLNAVPKTLKVSLTGGK"
     gene            14026..14715
                     /locus_tag="KNP36_002432"
     CDS             14026..14715
                     /locus_tag="KNP36_002432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0874295.1"
                     /translation="MDRYSEITNKNQREIVLLKGFPCIWGKCSFCDYIDDNSNLEEEM
                     NKLNLKVLKNVTGKYGVLEVINSGSCFELPKDTLEKIKCIIKEKNIKKLFLESHWSYK
                     NRLKEMREYFEIPVVFKIGVETFDNDFRNNILNKNANFKTPQDVKEYFDSPCIMVGIK
                     GQTKEMIDKDIEIILNTFEKATVNVFINNSSSIKRDEELVKWFVSKYKFLDENPNIEV
                     LYNNTDFGVGD"
     gene            14842..15570
                     /locus_tag="KNP36_002433"
     CDS             14842..15570
                     /locus_tag="KNP36_002433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBF0874296.1"
                     /translation="MMFDRGKWNKLDYNELLEYMMSIQDIKYRDFNKKLIPGTENIIG
                     IRVPNLRKLSKEISQGNWKEFLEVAQDTYYEEVRLQGMVIGNINSNFEETLYYVKRFI
                     PKIDNWSVCDGFCSDLKSMKKYKENMYDILKKYVYSKNPWEIRFALVMFLIYYVDDKH
                     IKEIFEYCNNIQSEEYYVKMGMAWLLSICFIKCEEETFLYIKNNNLDDFTYNKMLQKI
                     IESNRVDLEKKNIIRSMKRKTRRC"
     gene            15584..16258
                     /locus_tag="KNP36_002434"
     CDS             15584..16258
                     /locus_tag="KNP36_002434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBF0874297.1"
                     /translation="MNNNEDRIDKFLELQSKGFKFAEIAQNLKISQSTLRTFLNKKGY
                     KSEKGKYILKDELNYNKSLDNRNLEEEKAKEYEKSKKNTISNRKKVSTKKKISNEKAL
                     SKSVEQIEFNDTGLKNAKPKQNIKPKKDRKINITQEDLDKLCEVYDWYLEVKDYNIKP
                     KKVSNKKDVHIDDEHIDELKTTRIRIDKEIWNDFERLCSNSNFEKHQILTQALKEFMK
                     KYKNLL"
     gene            16284..17120
                     /locus_tag="KNP36_002435"
     CDS             16284..17120
                     /locus_tag="KNP36_002435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874298.1"
                     /translation="MNKIVKKSISLMIILTIFIFMLTACEKDEQPDSVDIQTEDKNEI
                     KIDEGNAKVLNIGKSEIINIDEGDKVDTSTKVENNSTFNISNVELIYNEYDENKKIIS
                     SDSKALLDMTLMPGKVAYIECGHKTFVKGVEVYAYEYEAEGKIVYVNLKENTINIRNN
                     NIKLENSSQYEVLSTSELKKVNESNEGITYQVKVKNSSSKDLGNIILKTAEVNENGEY
                     LTVNRVPSYKILKPSEETDIDILCSTKAKSVEIVGYTYDDIKEKANVDIDLKSHKVKI
                     DK"
     gene            17136..17807
                     /locus_tag="KNP36_002436"
     CDS             17136..17807
                     /locus_tag="KNP36_002436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874299.1"
                     /translation="MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLINQNIY
                     DLVILDLMLPNINGFDILKKMRINNIDTPVLILTAKETLDDKVEAFTIGANDYLTKPF
                     YMEELVARVYAILRTNGKIKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEY
                     FVLNKGSILLKEQIYDRIWGIDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGY
                     IFDDK"
     gene            17797..19029
                     /locus_tag="KNP36_002437"
     CDS             17797..19029
                     /locus_tag="KNP36_002437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874300.1"
                     /translation="MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSG
                     IDSEINDELEYIVSQFKRTSFLNPIRLKDPKDMVYVYEDGRISYYTQNEYFDELLPDR
                     RLDKKNSFFKYTENGYTFRELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISV
                     IITYFVAVYLTRKALIPIETAWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTV
                     NDEVETIATAMKETRRLKKMITDLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIA
                     EFQEKRFVFNSKLKNKVIITDKNKLRQLILIFIDNAFKYTKLGDEIALELKEDIEDEV
                     TLLISDTGIGIKKEEIPLIFDRFFRSENVRNKDLEGSGIGLSIARMISLNLSIDINVT
                     SDVDIGTTFELSIPKKLK"
     gene            19179..19496
                     /gene="trxA"
                     /locus_tag="KNP36_002438"
     CDS             19179..19496
                     /gene="trxA"
                     /locus_tag="KNP36_002438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HBF0874301.1"
                     /translation="MAKVINTSEFRSSVEGSKGVVVVDFFATWCGPCNMLGPVFAELG
                     EEMKDKARFVKVDIDESLEIAQQFNVSTVPTMIIFKDGKPVETLIGFMPKNKIEMQVK
                     SYL"
     gene            19513..20391
                     /locus_tag="KNP36_002439"
     CDS             19513..20391
                     /locus_tag="KNP36_002439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBF0874302.1"
                     /translation="MRYDIAIIGSGPAGLSAAINAKIRNKTIIMFGNDNLSNKLVKAP
                     SIDNYLGFYDISGDELKDKFKSHIDSMDISIENKRINNIYAMGEYFTIMSGNDMYEAT
                     TVILATGVEYTRPIKGEEEFLGRGVGYCATCDAPLYRNKKVAVIGYNEESKEEANFLS
                     ELTSKTYFIPMYKKDNLMRSSDNLDDSIEVIHDRPVQIDGDKLVNKVSFKENHIEVDG
                     VFVIKDSTAPSALVPGIEIDGIHIKVDNNMKTSIDGCFAAGDCVGKPYSYIKAAGQGQ
                     IAALNAVYYLDKLKRA"
     gene            20661..21029
                     /locus_tag="KNP36_002440"
     CDS             20661..21029
                     /locus_tag="KNP36_002440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBF0874303.1"
                     /translation="MENLVKIFKALSDETRLNILILVSKRNICQKGISKYLGISDSAV
                     SQHIKILKDVGIITGYKEGYYVLYHINKESFNICVDFINSMLSNSSESFIDVFDVNTI
                     HLGCSKECKSIKKCCKRREK"
     gene            21032..21403
                     /locus_tag="KNP36_002441"
     CDS             21032..21403
                     /locus_tag="KNP36_002441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NifB/NifX family molybdenum-iron cluster-binding
                     protein"
                     /protein_id="HBF0874304.1"
                     /translation="MKVCIPVEENKGLDSKPYGHFGSAPIFVVCDLESGEVKSLDNGD
                     LDHEHGKCQPLKALSGTAVDAVVVGGIGQGAIIKLNGMGIKVYRAEGDTISANLDLLK
                     NGKLVEFPSDHTCSHDGCGHH"
     gene            complement(21548..22003)
                     /locus_tag="KNP36_002442"
     CDS             complement(21548..22003)
                     /locus_tag="KNP36_002442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874305.1"
                     /translation="MNINTVQGDSIEVLLRQLGATRISKVSSTLYFIKFDLGDGWEIS
                     YTYNINAKDQYFLQRIEPYPIGRGLFNDEYEIVSFISKDLKKFLNAKNSSNFKTFVEV
                     TRKVNSIIDNVEELFLNYNVDGDDLKTLNKELNDILNDIDYIEKHTKKI"
     gene            complement(22042..23307)
                     /locus_tag="KNP36_002443"
     CDS             complement(22042..23307)
                     /locus_tag="KNP36_002443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ArsB/NhaD family transporter"
                     /protein_id="HBF0874306.1"
                     /translation="MEFQQIIAICIFLIVMAAIITEKVNRSVAAVGGALLMIIFNILT
                     LDEGLSHIDFNTIGVLVGMMLFVAVVKNSGLFEYIAIWTAKKAKGDPWKIMICFAIIT
                     AILSAVLDNVTTVLLIGPMTIVITQILGLNPVPFLITQILASNIGGTATLIGDPPNIM
                     IGSAANLSFMDFVINLGPAVIVILAITIICFRFIYGKELVVNERAKNAILKLDEKKSV
                     KDKPLLIKSLILIAFILFGFMFHSTIHIDSSVVALTGASIMLLIGKQDVDEIMAGIEW
                     STILFFMGLFVVVGGLVEVGIINKLAQALIGLTEGHLVFTMLLILWLSAIVSSFLDNI
                     PFVATLIPLILTMQAEGIDVMPLWWATSLGACLGGNGTLIGASANVVLAGIGNKHGHP
                     ISFKEYFKIGFPLMIISIIISTVYLIIKF"
BASE COUNT         9144 a         2623 c         3673 g         8203 t
ORIGIN      
        1 aatatcaaaa ataataaaaa taattgaaaa tgtataattt cccagaaaaa taataaatgt
       61 aactccaata ataaacacac ctataaatta taaaataatt taagctttat ttaaggttag
      121 tattatattt atataagatt taagttttaa tatatatgtg taattaaaat gatttaggag
      181 gagaaatata ttggtaaatt gggaaataaa aaaattggct aaatctaaga gtatgtttat
      241 atctctaggg atattagtgt taatactaat gattagtatc tttattacgc ctgttttaga
      301 aacagaaagt tattatatag ataaagaaaa aggacgtata gaagatacga gaagtggtat
      361 cgacgtaggt aatgagaaat ttcaaaataa gattaatgtt ttaaagcagt tttcaaatca
      421 aacagataca ggtgaatttt ctaaaaaaat tgaattaatg tcaaagaaaa aacttgataa
      481 tctaagtgtg aatgaatata aggatattag tttttggaaa gtatttaact atagagtcac
      541 aaattcactt ataaatgtag gaatgttaat cattatatct ataattatat ccaatattta
      601 tgtagatgaa gtcgttactt cggtaaaaga tatcatacta tcatcaaaag agaagaaaaa
      661 agcattaaag tctaaaatat ttgttgcttt attagttcca ttagtaattt attctgttta
      721 tttaatggga atatttatta taacttgtat gcaacaagga gtacctgtta atggagactt
      781 agaatctttt agaatagtag acaatgtagt tgcattgaaa actaatttaa gtataacaaa
      841 gtatgtaata ttaaatatag gcatagagct tttgatgttt gaaggatggg ccatgatagc
      901 catatttggg tcttttataa gtaagtcttc aatatcttca ataagttttt ttatatttat
      961 tatatctata actaagataa tgtcggtaat ccatatatta cctaaaaaat tactttcagt
     1021 tgtatcaaat gtaaattatt atgatttgat atttggtttt aataaaataa taggaaatta
     1081 tctaggtgat attatgatat ttaaagtgaa tatagacatt gtcaatatag caataggact
     1141 tttgatggca atattgatag gtgctatgtc attatgtttt ttagtaataa aatcagatta
     1201 tataagtaga taaaagggga gttaagatga ataaattaga aatagaaaat ctttcaaaga
     1261 tatatggtaa aaaagtagca aacgacaaga ttacagtaac tctggaaaat ggagtttatg
     1321 gtcttctagg accaaatgga gcaggaaaat ctacattaat gaaacaaata acaacgttga
     1381 taaaacctga tgaaggtcag atactttata atggtgagga tatatttaaa atggatgctg
     1441 attatagaaa tattttagga tatttgccac aagaatttgg agtttataaa aattttacag
     1501 caaaagaatt tttacagtat attggagctt taaaaggttt aaggggaaaa tatttaaata
     1561 gtaagatagg agaattatta gatttagtag gtctttatga tgtgagaaat aagtctatag
     1621 gaaaattttc aggaggtatg aagaggagag ttgggatagc acaagtttta ctaaacgacc
     1681 ctaagataat agtccttgat gagccaacag caggacttga cccacaagaa agagctagat
     1741 ttaggaattt aatagcaaaa atgtctagag ataagataat aatactttct actcatataa
     1801 tttccgatat agaatcagtt gcaaaggaaa caataatgat taaagatggc aaactcctaa
     1861 tgaaaggaac acacaaagac atattaagtc acatggaaaa taaagtatat aatgttcaag
     1921 ttaaaaatga atgtgaagtt gatgatatac aatctaaata taaggttgta agtattcaaa
     1981 gtgatattga ttcagtagta cttagaattg tttcagagga tattccaagc gaggataata
     2041 tacaaccagt tcaagcaaaa ttcgaagatg tatacatgtt ttattttgat ttagaagatg
     2101 caagggaggt gtagtagaaa tgatgtattt agttaaagct gaaatgataa aaatattaaa
     2161 atcaaagagt gtttggataa tttggctgtt tttaatattt tttggatttt ttctgattag
     2221 aaagtttgat gttttagata cttatgcaga tatattttac aagatagaag gctcaatacc
     2281 tctaataggt ttgataatgt ttataataac ttctggaaat tacattaaag aatatgattc
     2341 taatatgaca ggtttaataa atacaactaa aaagggaaaa aaatcagtag tattatcaaa
     2401 actagtagct aatggattaa ttttatctat tattaatatt tcttttatat tgttagtagg
     2461 aattagaggt tttagttttt ttgattttaa aaatttaaat gaatcgattc ataacttatg
     2521 gtactttgga aatagtaatt taaatcttac agtaatacaa atgtatataa ttgttatatt
     2581 gactactatt tttgcttctt ttatatttgc acaaataggc ttaacacttt catctatatt
     2641 taaatcggct gtaattccat ttatactagg tggattgata atggcaattc catactttag
     2701 tgtaggtttt ataccagata aagctataaa atttatgtca gtgactccaa attggattat
     2761 gatgagccaa caaatggtta agtataatgt accaagtatt ttgatagttt tttctatagt
     2821 aatctcaatt atattaatga tagtgttaac taaaataaca tatgaaaatt ttacatcaag
     2881 caaaaggttt taactaaaaa taatagtaat tttatttata ttttagttta attaaaaata
     2941 agataaatga attttagata aaatatatgc taatatatat gtaaattatt acaggaggtt
     3001 gtttatggaa aatcgtgttt taataataga tgatgaagta gaaatattga agcttttaga
     3061 aactgtccta aaaaaagagg gccttaataa tatatatact gcaaaaacta aaaaagaagg
     3121 attagaatta tttaaaagta ttaatcctga tttgattgta ttggatatta tgttaccaga
     3181 tggcgaaggt tatgatattt gtaaagaaat aagaaaaacc tccaattctc caataatatt
     3241 tttatcagct aaaaccgaag aattagataa gttacttgga ctagcgattg gaggagatga
     3301 ttatgttaca aaacctttta gccctaagga agtggctttt agagttaaag cgcatttgag
     3361 aagattaagt tattttagtg atgctcaaaa cgaaagtaaa aatctaaata ataatgaaga
     3421 aaaaattata tcatttggcc catatatatt aaatgaaagt agggcagaac ttataaaaga
     3481 tggaaaatct ataggactgt ctgcaaagga actaaaaatc ctatctttat ttgcacataa
     3541 tcaaaatcaa attataagta aagaaaaact atgggataaa gtgtggggag aagattatgt
     3601 tggatttgac aatactataa tggttcatat aagaaaaatt agggaaaaat tagaggataa
     3661 tccttcaaag cctgaatata ttctgacaat aaaaggtctt ggatataaat tagcagtaaa
     3721 ggaagattag aatatgaagt ggaagattac tagaaatttt atatttacaa ttgtgtttgt
     3781 agctatatca gtagtaatta taaatatcat atctatattg tatgtgattt caactaatag
     3841 tttttttaaa gttgtagatt ctggaaataa tcctgaagaa tttgcacgtt cttttgaaaa
     3901 agatttatat gaaaaagatg gagaatttaa actatctaag attggagctg aaaaattaga
     3961 aaaatcaaat tcctggatac aggttttaaa tgatttagga gaggaagttt atggagtaaa
     4021 tgtgccaaag gatactccca aaaaatatac accctttcaa atggtgaata attacaagta
     4081 tatagaaaca aagtatgtta attttgtatt agaaaaatat ttaaacaaaa aacatctaaa
     4141 cataatagta ggtataccta gtagagatat atcaagaata attttaacct attctcaaaa
     4201 taacattaaa aaaactttaa ataaagttat cattataaca ctagtaattg atagcgtggt
     4261 agctttaggt gtaggatatt tatttagtag aaaacttaca aaaccaattt caagcgtact
     4321 atggagtatt gagactatgg ctaatggaaa ttatagttta tatcttaagg acagaggtat
     4381 atatgaagaa gtttttaaaa atataaatat gttagctgat actttaagag taaatgaagt
     4441 tgagagaaaa gaaaatgaag agttgagaga ggaatggttg gcaaatataa cacatgatat
     4501 aaagacacct ctagcatcta tacaagggta tgcagagata attaatgaca aagattatga
     4561 gtttgaagaa gatgaaatac aagagtatac agaaattata tataataagt ctaagtatat
     4621 aaaagattta gttgatgatt taaatttatc tactcgatta aaaaataata ctatagttct
     4681 ggacaagaaa aaaataaatt tagtcagttt agtcagagat ataataattg atattttaaa
     4741 tgataataga tataaaaata ggaatattga atttgaaagt aatgaagatt taattgaagt
     4801 atatgtagat tcaatcttat tcagaagggc tataaccaat cttatattta attcaatagt
     4861 tcataatagc gaaggaactt tgataagtgt agaaattgta aaaaaagata atatagaaat
     4921 tataataaaa gatgatggaa ttggaataag caaaagtgat ttgaaacata tttttaaaaa
     4981 atattataga ggtactaata caggtgagat gcataaaggt tcaggtcttg gtatggctat
     5041 ttctaaagaa ataatagaga ttcataaagg taaaatttat gtaagtagtg aaattggaat
     5101 aggaacaaaa attattatag agataaaaca aaattaggag atatgatatg gattttttta
     5161 aaaaaggtat aagtgggttt actattaaga ttttagcatt aatatttatg acatttgacc
     5221 atatagcagc atttatgcca caaacaatgc aaataccaat ttggtttcat tgggtaggca
     5281 gaatatcagc accactgttt atattcatgg ctgttgaagg attttatcac actagtaaca
     5341 gaaaaaaata tataagtaga ttgtatattt ggtctgttat tatggctata ggaaatcaaa
     5401 taattaataa tgtattttca catccagaag gagctataat tataaataac actttttcaa
     5461 cattattttt aatagcgatt tatttacaag caatagagtt cataaagaaa tttagaaaag
     5521 agaaagaaat taaatatttt attataggat tattgatgat aatcattcct ataattttag
     5581 gaatatttac agtagcttta ctttttaaag tcactaacag agttattgct ttatttatga
     5641 ttttggtacc agtaccattt ttagtagaag gtggaccaat ttggattata cttgggatta
     5701 ttttttattt gtgtagaggt aaaaagttca gtttgagtat ttgttatgtt ttaatgtgta
     5761 tatttatatt tacaacaatg tcaaatggag attatagttt aaaaaattct attttacaaa
     5821 attaccaatg gatgatgatt gcttctctac ctttaatgtt actttacaat ggagaaaaag
     5881 ggaagagtat gaagtattta ttttatttat actatccaat ccatgtatat atattgtata
     5941 tcttaggaat atacttaata aatggttttt gattgtaagt gatattttta atacaaaatg
     6001 aacagtatga ggattgtttt aggtctatta aaattgttat ttagatgaga tttgtagaat
     6061 atttaaattt atgagcagaa attcagttat tgtaatttca ataacattag aatataatat
     6121 tataatttat ttagaaatat atgatgttat acatggtttg gttattaatg taataataaa
     6181 acagaggttt gatataaaat tcaatacctc tgttttagtg ctttttatcc tacatttatg
     6241 cttattttat ttataaatta gtgttttgtt ttaattaata ttagtacatt ttttatttat
     6301 tttataaaat tagtcataat tgtttcttca tattgtggtt ctttaattcc agctttttta
     6361 cctgctgata tacacttaag aagccatgcc atgttttctc ctagagttcg catagtctgt
     6421 aatccttctt catccttcat aacatcctct ggagtaaagc catgtacctg gttccaatac
     6481 tgtgatgata caataggcat attgctgatt gaaaaatatt tatttagttg gtcaaatgtt
     6541 gcacttgcac caccacgtct acatgacaca actgaagcac ctaattttgt agccatgcga
     6601 ctcccagcta tgaaaaatag acggtcaaga aaagaagtta attgaccagt tgcactagaa
     6661 aagtaaacag gagaaccaat aataatacca tcaatattat ccagatcttc aatcaattca
     6721 ttaactttat catttcgaat acattttcca gtttcaaaac aggatgcgca actaatacat
     6781 cctgggattg tttctttacc taaatacagt atttctgttt taatatcgtg tttactcaat
     6841 actttagtaa tctcatttag tgctgtataa gtacatccat attggtttgg gctaccgttt
     6901 atcaataaaa ctttcattat aaatttcctc caatgaattt tatttaatag attttctaag
     6961 agacattatt ttttataaaa taggattttc atgaatatta tcaatttata tagaaatgtc
     7021 taatcttaga atcctattta aaataacttt ttttttagta aatacacctc ctattataaa
     7081 attgactttc aattattctt acactataat tttattataa attattctaa aaacaagtac
     7141 gcacattttt gttcaatact aaccaaaagg agagtgtaat atatgagtat agactgtata
     7201 tcaaatacag atttaagtga aacaggattt agttatacac tttcactgat tagtggtaaa
     7261 tataagatga taattcttta ctgtcttgta gaatttgaag ttgtaagata taatgcatta
     7321 aaacgttata taaatactat ctcctataaa actttgagtt tatcattaaa agaattagaa
     7381 gcagataact tgattattcg tactgaatat cctcaaatac ctcctaaggt agaatatagt
     7441 ctatcagaaa ggggaaaatc tctgattcca attttagatg caatgtgtga gtggggagag
     7501 aggaatagac cttaattttg tatctgtaga taccataaaa agactgtgag taaaattgtt
     7561 tgaataatct actcacagtc tatatttaaa ttaatagtta gtatttttaa tttataaaaa
     7621 tactaaaaaa tttattatga aatttcacca ccaatttctt ttacatcttc tttatatata
     7681 atacaagctt ctatagctaa ttctaagcct tttactattt cttctaaaga catgaatggt
     7741 gtattttttt tatctattac ttgtgaagtt gtatatggga tgtgtataaa tccacccctt
     7801 atattaggat atttcttgtc tatcatataa agaattccat acatcacatg attgcaaaca
     7861 aatgttcctg cagtgtttga aacactagct ggaattttat tttcattcat atgttttacc
     7921 atagctttta caggcaattt tgaaaaatat gcaggttcac catcttcttt tataatagta
     7981 tctataacct ggttaccctc attatctttt attctaaaat catctatatt tatagcaact
     8041 ctctcaggtg taatgtcaaa tctacctcca gcttgtccaa ctgatattac tatatctgga
     8101 ttgtgctctt gaatagcttt atctatagct tcaacagatt ttgtcataac tgttggtata
     8161 gttatcttta tgatttctgc accgtttata ttattattga ccctttcaac tgcttcttga
     8221 gctgggttta ttggttctcc gccaaatggg tcaaatcctg ttaacaaaat tttcattatt
     8281 ttacctccta attatattaa aatcctaaaa agtacattac taatatgtgg gctataatta
     8341 ataccaaagc aactggagct tgatatttta taacaatata atcattttta cattctagca
     8401 aggctgctgg aactatatta aaattagcag ccattggagt aagtagagtt ccacaatatc
     8461 ctgctgttaa tgctaatgct ccaattatag caggatttcc accttgagac aatacaaaag
     8521 gaataccaat tcctgccgtt atgactgaaa atgcggcaaa tgcatttccc attatcatgg
     8581 taaatataac catacctaat acataagcta taacaccaaa taatctgcta tcagcaggga
     8641 ctacaccaga tatcatggtt gaaataactt caccgactcc ggcttgagta aataaagctc
     8701 ccaatgcaac taaaagttgt ggtaacatac tagcaggtcc catttgttga agtaatcttg
     8761 agccatcttg aactgatgta gcaggttttg ccttagttat tataagggct gatattaatg
     8821 caattattga acccacacct attgcaaact gagaagaatt atcaaaatta gaaagactca
     8881 tagctactac tactgcagca aatgctaata ttaatgatgg tataaatatt ttatttttaa
     8941 gtttgtctgc ttgttctttt ccaaaatttt catctggttc ttcatacttt gcaaatacaa
     9001 cttgtttaga aagtgttaat aaactagata atattaatat tattcctatt atattggctg
     9061 gaatcaatct accaaatatg aatggcagtg atataagtat ccaaaataat gatgtaccat
     9121 atttcttatt gttatttatg gtagtaaaag acttatatgc tataacaatc attaaaaatc
     9181 ccattagtgc gtaaaagatt tccaatgata tgtttataaa attttgcatt tttattcctc
     9241 ctaaataaaa ctatttttta tgacttttgt ttaatttttt atcatataag gtaaactgga
     9301 ttgtagccac tacaagtgct attactgcca taatagtact agcctttacg atattaagtc
     9361 cagttacatt gtatccaaat tgagtcagag tagatgctat aagtaatact ccactactac
     9421 ctgcaaataa gttttgacca taaaaatttc catagttttc tgatgcagca gataatgcct
     9481 ttatggcttc ttcatccgat tcttttagtt catcactatt acttaaacca gcagcttgtg
     9541 ccataggatt aacaagtggt cttacaaatt gaggatgtcc actcattctt attgatagag
     9601 caccagctat ttgtctagct atcatgtata tagtaagtac ttttcctgtt gtaagtcttt
     9661 ttaatttttc tattaaagaa acagctcttt gtcttaaacc atatctttct aatacaccga
     9721 ttactggcaa tgttaatatg aataatgata cacctctgtt tgagacaaaa gaatctccta
     9781 aaattgtaaa aatttgatta aaatctaatc ctgcaacaat tcctgttgcc actcctgcta
     9841 ataatacagt aaatagtgtg tcaattttaa gtataaatcc aattacaact atcaatatac
     9901 cgattagttt tatcataaat tgttctcctt ccatttctat atgttttaat ttaaatttat
     9961 ttaatggata aagttaaact ctttttatag tatttgcgtt aataggacta ttattataaa
    10021 atttaataaa aaatagggaa gatgttttaa agtatcaaag taaataatgg ttgtgtatag
    10081 gaatttgaat aacaaagatt atattttaag ctaatatgaa ttgattttgt aagtctatag
    10141 tttaagtata tgtcaatatt tgaaatagta gttttaaatt aaacattata ttataaaaag
    10201 agaatgtgcc aaacatagag acaagtgtat ttttctctgt tgaaatgata aaaatatatt
    10261 tgatttcata caaaaagaga gtgtctaatg aattttttag ttcattagac actctctttt
    10321 tgttatgatt aataaaacat atttgttatg attaataaag catatattaa gtgctagttt
    10381 cattagattt cactaagaaa aataaaattt tgataaagtt taaagactat tttgagcaat
    10441 attacttata aataaaagaa tttatcatag aaataattag ctttatttta gctattaaga
    10501 tttattaaaa aattatctat attatcctgt gatattctaa aactgtcata attacctttt
    10561 gaaacagcct tcataataag tttatctaaa aatttcattt tttctaatcg agcttcacta
    10621 ccaaaaattc caatagcatt tgcactttct aataaggatg atggaaaatt tgattttaaa
    10681 tatttatctg cttgttcaga aaagccacag caaaggaaaa tgccaacttg ttttttgttt
    10741 aataactcta cattatcatt acatagcacc tgtatttttt ttgaaactga accaacatat
    10801 atagaacttc caataataat tttatcaaat tttgataact caattttatt attattatta
    10861 ttaatatcaa caatagtgac attatctgat agtttatttt ttagtatatt tgcacagtct
    10921 tttgtacaac catatttact tgaatatata ataatagtat tcataattat tctccctttc
    10981 ttaaagcatt ttctacagct tttcgtatag tattactgct ataagttgca gaagttatag
    11041 catccacatc taaagactgt tgtttaataa tacttgttgt aattttttca gcaggtttac
    11101 ctaaaagatg gtcgtgtttt aagatattaa tattttggat tttaccatta ttaacttcaa
    11161 cagacacagt agcttttacc aagttattat cagcacttcc agtataaatg ccatttttaa
    11221 cattattaat atctatatct tttactacca agttttctgg ctttaagttg cttacaatta
    11281 caataataat gcatataaat acaaagaata gagcaataga tatttttaca tattttttct
    11341 ttttattagt agccttgttg cgaattttca ttgtaaagtc ctcccactaa aatatctaag
    11401 aaattttcta taagttgaga aaaattatgt aaagaatata gtttattttc aacaacacat
    11461 aaaacgaatc ctaacaatgc acttataagc atccatgagc ttttatctat attttttttg
    11521 aatattcctt gttcaattcc aatggaaagg aatttatcaa gcatttttat accattattg
    11581 ctaggcgtat tgtttgtatt ttcagatgca aatataatat tcattctact atgcatgata
    11641 gattttgcca tctctggttc actagaaaga gtttttataa agctagtcat aatttctatg
    11701 atttgtttat ctattggtag tgatgagcaa ttattcataa tgtcaatggc attactttct
    11761 actgtgttat aaagtttatt ggtcatatcg ctgataatct ctgctttgtc tttgtagtaa
    11821 agataaattg tagttggaga atattctatt tttgtagcaa tttttcttat tgataaattt
    11881 tcatatccat gttggtttat aatttcgatg ctagcatcca taatcttttt cttcatttct
    11941 tctttttcat ttttacgtct ttctttgata ctcatataat cacctctttg cttaacggtg
    12001 ttaagttaat ttacactgtt attgtataat ttaattttaa tactgtcaat aaattattaa
    12061 ataatataag ttaatatatt tttatggata ataaattaat gttattaatt gtaatattta
    12121 agatattatt gtataataat aatcggttta aatgcgccac atcttattaa agttggttca
    12181 taattctaaa taaactttaa taagatacat taaaatataa taaattcttt tatgctataa
    12241 aatttatttt atagctatta aatcagatgt ttaaaaattt tttaacggtc tatagttttt
    12301 aagagtctta tagtaagtag cctaaaaata tgattttaca tctgtacttg ttcgagaact
    12361 ccaagtataa aaaactaagg aattatatag tggcagtata taattaatac ccttagacac
    12421 acctttttga aagtggaaaa aagatgtgta gttctcctcg accacaaatc aaggaggata
    12481 aaaaatggaa aagagaaaag taataattga ttgtgaccca ggaattgatg attctttggc
    12541 aattcttctg gctttaaact caccagagct agaagtaatt ggaattacca catgttgtgg
    12601 aaatgtccca gcaaatatag gtgcagaaaa tgcactaaaa acacttcaaa tgtgttcttc
    12661 actaaatatt ccagtatata taggagaaga agcaccacta aaaagaaaac ttgtaacagc
    12721 tcaagataca catggagaag atggtattgg agaaaacttt tatcaaaagg ttgtaggagc
    12781 taaagcaaaa aatggagcag tggattttat aataaatact ttatataatc atgaaaaagt
    12841 atcaataata gcacttgcac cacttacaaa tatagctaaa gcacttatta aagataagaa
    12901 agcatttgaa aatctcgatg agtttgtatc tatgggagga gcatttagga ttcatggaaa
    12961 ttgctctcca gtagcagagt ttaattattg ggtagaccca catggagcag attatgttta
    13021 caagaattta tctaaaaaaa tccacatggt aggtttagat gtaactagaa aaattgtact
    13081 tactcctaat attattgagt ttataaatag acttgataag aagatggcaa agtatataac
    13141 tgaaataact agattttata ttgatttcca ttgggaacag gagggaataa ttggctgtgt
    13201 gataaatgac cctctagcag tagcatactt tatagataga agtatatgta aaggatttga
    13261 atcatatgta gaagttgtag aagatggaat agctatgggt cagtctatag tggattcttt
    13321 caatttctat aaaaaaaatc ctaatgcaat tgttctaaat gaagttgatg agaagaaatt
    13381 tatgtacatg tttttaaaga ggctttttaa aggttatgaa gacattatag actctgtgga
    13441 aggagtgata tagtgtgaaa agaaaaatat gtgtaaaaac tattacactt atagcttttg
    13501 gtatttctat aaatataata ggcgctttta tagctatggg attaagatta cctgtatact
    13561 tagattcaat aggaactata atgatagctt cacttttagg acctaaatac gctgttgtta
    13621 caggtgtgtt tggaagttta ataagtggaa ttacgtttga tgtgtattct ctctattttg
    13681 caccagttca aatatcaacc ggattacttg ctggaatagc atttaaaaag aattttttaa
    13741 ggggtttaaa aactccacta ggagtacttt tatttgccat tccaacatct ataataagtt
    13801 caataatttc agcattttta tttggaggta tgacctcttc aggttcatca tatatagtgc
    13861 aaatcttgaa agtgttagga ctgggggatg tttttagtgt gtttgtaacc caagtattta
    13921 ctgattatgg agataagctg ttagcagttg ttttagtgaa tttaggatta aatgcagttc
    13981 caaaaacttt aaaggtatca ttgactggag gaaaatagat agaaaatgga tagatatagt
    14041 gagataacaa ataaaaatca aagagaaatt gttctgctta aaggatttcc ttgtatatgg
    14101 ggaaagtgtt ctttttgtga ttatatagat gataattcta atttagaaga agagatgaat
    14161 aaattaaatc taaaggtttt aaaaaacgta actgggaaat atggagttct tgaagtcata
    14221 aattctggaa gctgttttga attacctaag gatactttag aaaaaataaa gtgtattata
    14281 aaagagaaga atataaaaaa attattttta gaaagtcatt ggtcttacaa aaataggctt
    14341 aaggaaatga gagagtattt tgaaattcct gtggtattta aaattggagt tgaaaccttt
    14401 gacaatgatt ttagaaataa tattttaaat aaaaatgcaa attttaagac tccacaagat
    14461 gtaaaagaat attttgattc accttgtatt atggttggaa taaaaggaca aacaaaagag
    14521 atgatagata aagatataga gattatccta aatacttttg aaaaagcgac agtgaatgtt
    14581 tttataaata attcttctag tataaaaaga gatgaagagt tagtgaaatg gtttgttagt
    14641 aagtataaat tcttggatga aaatccaaat atagaagttt tatacaataa tacagacttt
    14701 ggtgtaggag attagcatta atttagttta aatttaaaat tgaaaagttt cttatgtttt
    14761 tgaaaaagct tctaatagtt agaagctttt tttgtagagt tttatgttac aataagaaaa
    14821 aaggaattaa ggagcaatta aatgatgttt gataggggaa aatggaataa attggattat
    14881 aatgaacttt tagaatatat gatgtctata caagatataa aatatagaga ttttaataaa
    14941 aagcttatac ctggaacaga aaatataata ggtattagag ttcctaattt aagaaagtta
    15001 tcaaaagaaa taagccaagg gaattggaag gaatttttag aagtagcaca ggatacatac
    15061 tatgaagaag ttaggctaca aggtatggta attggcaata taaatagtaa ttttgaagaa
    15121 actttatact atgtaaaaag atttatacct aaaatcgata attggtcagt ttgcgatgga
    15181 ttttgttctg atttaaagtc tatgaaaaaa tataaagaaa atatgtatga tatacttaaa
    15241 aaatatgttt attcaaagaa tccatgggaa attagatttg cattagttat gtttttaata
    15301 tattatgttg atgataaaca tattaaagaa atatttgaat actgtaataa tatacaaagt
    15361 gaagaatatt atgttaaaat gggtatggca tggttgctat caatttgttt tattaaatgt
    15421 gaagaggaaa cttttctcta tataaaaaat aataatttag atgatttcac ttataataaa
    15481 atgctacaaa aaataattga atcaaataga gtagatttag aaaagaagaa tataataaga
    15541 agtatgaaaa gaaagacaag aagatgttga cggaggaata ttaatgaata acaatgaaga
    15601 cagaattgac aaatttttag aacttcaaag caaaggattt aaatttgcag agatagctca
    15661 aaatctaaag attagtcaaa gtactttaag aactttttta aataaaaaag gatataagtc
    15721 agaaaaaggt aaatacatat taaaagacga attaaattat aataaaagtt tggataatag
    15781 aaacttggaa gaagagaaag ctaaggagta tgaaaaaagt aaaaagaata ctataagtaa
    15841 tagaaaaaaa gtaagcacca aaaaaaagat ttctaatgaa aaggctttaa gtaaaagtgt
    15901 tgaacaaatt gagtttaatg atacaggttt aaaaaatgca aagccaaaac aaaatattaa
    15961 gcctaagaaa gatagaaaaa taaatataac tcaagaagat ttagataagc tttgtgaagt
    16021 atatgattgg tatttagaag taaaagatta caatataaag cctaaaaaag tatctaataa
    16081 aaaagatgta catatagatg atgaacacat agatgaatta aaaacaacaa gaatacgtat
    16141 agataaagaa atatggaatg attttgaaag attatgtagt aattcgaatt ttgaaaaaca
    16201 tcaaatactt acacaggcat tgaaagaatt tatgaaaaag tataaaaatc tactataaaa
    16261 tactactata tgaggtgctt aatatgaata aaatagtaaa aaaatcaatt tctctaatga
    16321 ttatattaac aatatttatt tttatgttga cagcatgtga aaaagatgaa cagcctgatt
    16381 cagttgatat tcaaacagaa gataaaaatg agataaaaat agatgaggga aatgcaaaag
    16441 tattgaatat aggaaaatca gaaattataa atatagatga aggtgataaa gtagatacat
    16501 caacaaaggt agaaaataat tcaacattta atatatccaa tgttgaattg atatataatg
    16561 aatatgatga gaataaaaaa attatatctt cggatagtaa ggctttgttg gacatgactt
    16621 taatgcctgg gaaagttgct tacatagaat gtgggcataa aacttttgta aagggtgtag
    16681 aagtttatgc atatgaatat gaggcagagg gtaagattgt gtatgttaat ttaaaagaaa
    16741 atactattaa tataagaaat aataatatta agctagaaaa tagtagtcag tatgaggtgc
    16801 tatctacatc agaacttaaa aaagtaaatg aatcaaatga gggaattacg tatcaagtaa
    16861 aagtaaaaaa ttcatcatca aaagatttag gaaatattat tcttaagaca gcagaagtta
    16921 atgaaaatgg agaatattta acagtaaatc gtgtaccatc atataagatt ttaaagcctt
    16981 cagaagagac agatatagat atattgtgtt caacaaaggc aaaaagtgtt gaaatagtgg
    17041 gatatacgta tgatgatata aaagaaaaag ccaatgtgga tattgactta aaatctcata
    17101 aagttaagat agacaaataa aggtagggga tacttatgaa ggttttaata gttgaagata
    17161 ataagatact tttagaaagt gtagtagaag aacttagcaa gcattttgaa actgaaaagt
    17221 gtgaagatgg agaagaagct ttatacttaa taaatcaaaa tatatatgat ttagtcattt
    17281 tagacttaat gcttcctaat ataaatggat ttgatatcct aaagaaaatg agaattaata
    17341 atatagatac acctgtactt atattgacag caaaagaaac attagatgac aaagtagaag
    17401 catttactat aggagctaat gattatttga caaaaccttt ttatatggaa gagttagtag
    17461 ctagggtata cgctatatta aggactaatg gaaagataaa agaaagaaac ggattagaat
    17521 ttaaatcttt atatttagat acactagaaa aaagagtgta tattgaaaaa gaagaaataa
    17581 aacttcaaaa caaacagttt aacttgcttg agtattttgt attaaataaa ggttcaattt
    17641 tattaaaaga gcagatttat gatagaatat ggggaattga ttcagatgca actattgaaa
    17701 tagtggaagt atatgtaagt aatctaagaa aaaagctaag taaatatgga tatgataaat
    17761 atattaaaac taaacgtaag gtaggatata tattcgatga taaataagaa tgtatttacc
    17821 agtactaaaa atcatttaat aaaaatgtat attattgtag taggtagttt tttaataatc
    17881 ttttctatat ttatatactc atattttagg ggacttacat atagtggaat tgatagtgag
    17941 ataaatgatg aacttgaata tatagtctct caatttaaaa gaacttcatt tttgaaccca
    18001 ataagactca aagatcctaa agatatggtg tatgtatatg aagatggaag gataagttac
    18061 tatactcaaa atgaatattt tgatgagtta cttccagata gaagactaga taaaaaaaat
    18121 tcgtttttta aatacacaga aaatggatat acttttagag aattaaatgt agatgtaggt
    18181 agataccaaa tacagataat tagaaatata gattctgaga tgaattcttt aagacagctt
    18241 acatctgttc ttataattgg aatattaatt tctgtaataa ttacttactt tgtggctgta
    18301 tatctcacta gaaaagcttt aattccaata gaaacagcat ggaaaaatca agctaagttt
    18361 atacaagatg cttctcatga attaagaaca ccaataacaa tagtttcatc aaaattagaa
    18421 agtatgttaa aatccccaga aagtacagta aatgatgaag ttgaaacaat agctactgca
    18481 atgaaggaaa ctagaagact taaaaaaatg ataactgatt tattgtctct tactaaagag
    18541 gactctattg ttaaagttaa tttagaagaa atagatttag aaaagttatt ggaagaaata
    18601 tcagaagact atattgacat tgctgagttt caggaaaaaa gattcgtgtt taattctaaa
    18661 ctgaagaata aagttataat aacagataaa aataaattaa gacaacttat attaattttc
    18721 attgataatg cctttaagta tacaaaattg ggtgatgaga tagcattaga attgaaagaa
    18781 gatatagagg atgaggtaac tttacttata agtgatactg gtataggcat aaaaaaagaa
    18841 gagatacctc ttatatttga tagatttttt agaagtgaaa atgtaagaaa taaagattta
    18901 gaaggttctg gaataggact ttcaatagct cgcatgatta gtttaaactt atctattgat
    18961 ataaatgtaa cttctgatgt agatattgga actacatttg aattgtcaat accaaaaaag
    19021 ttaaaataat aaaaatataa aaaattgttt ttagaaatga agaatgggta tactaattag
    19081 tataaaatat aaaaagacct tataaaagta aatttatatt tataaatttc atagtataat
    19141 tatataggga taataaagtt taataggagg atttaaaaat ggcaaaagtt ataaatacat
    19201 ctgaatttag aagtagtgtt gaaggtagta agggagtagt tgtagttgat ttctttgcaa
    19261 cttggtgtgg accttgtaac atgttgggac ctgtatttgc agaattaggt gaagagatga
    19321 aggataaagc tagatttgta aaagttgata tagatgagag tttagaaata gctcaacaat
    19381 tcaatgtatc tacagtacca actatgatta tatttaaaga tggaaaacca gtagaaactt
    19441 taattggatt catgccaaag aacaaaattg aaatgcaagt aaaatcatat ttataaaaaa
    19501 tgggtgagta ttatgagata tgatatagct ataatcggca gtggtccagc tggattgtct
    19561 gctgctataa atgcaaaaat aagaaataaa acaattatca tgtttggtaa tgataattta
    19621 agtaataagc ttgttaaagc tccttcaata gataattatt taggttttta tgatataagt
    19681 ggtgatgaat taaaagacaa gtttaaatca catatagata gtatggatat ttcaattgaa
    19741 aataaaagaa taaataatat ttatgctatg ggagaatact ttacaataat gtctggaaat
    19801 gatatgtatg aagctactac tgtaatcctt gcaactgggg tagagtatac tagaccaatc
    19861 aagggtgaag aagaatttct aggaagaggt gtgggctact gtgctacatg tgatgcacca
    19921 ctttatagaa ataaaaaggt agcagttata ggatataatg aagaatctaa agaagaagca
    19981 aattttttaa gtgaactcac ttcaaagact tattttatac ctatgtacaa aaaagataat
    20041 cttatgagaa gttcagataa cctagatgat tctattgaag ttatacatga cagaccagta
    20101 cagatagatg gagataaact tgtaaacaaa gtatctttta aagaaaacca cattgaagtt
    20161 gatggagtat tcgttataaa agatagtacg gctccaagtg cattggttcc tggaatagag
    20221 attgatggca ttcatattaa agttgacaat aatatgaaga ctagtataga tggatgcttt
    20281 gctgctggag attgtgttgg aaaaccctat tcttatataa aagcagctgg tcaagggcaa
    20341 atagcagctt taaatgctgt ttactattta gataaattaa agagggctta atatttatat
    20401 tgattaactt tttaaagata tttataaaaa actgtcttga aataatttta ttatttcaag
    20461 acagtttttt atttttaagt tattaataaa agtattttaa aatctatatg taattacttt
    20521 tattaataaa actcaaagtt atattagtaa aaattggaat tatttataat atactccaaa
    20581 atttaaaaat aatggttgaa aaatctaatt aagagtacta taatttaatt aagtaattac
    20641 ttaatcaaaa tgaggtactt atggaaaact tggttaaaat atttaaagca ttgagtgatg
    20701 aaactagact taacatactt atattagtat ccaagagaaa tatatgtcaa aaggggattt
    20761 ctaaatatct agggatttca gattctgctg tttcacaaca tataaaaata ttaaaagatg
    20821 ttgggataat aacaggatat aaagaaggat actatgtttt atatcatatt aataaagaat
    20881 catttaatat atgtgtagat tttataaatt ctatgttaag taattctagt gaaagcttta
    20941 tagatgtatt tgatgtaaat acaatacatc taggatgcag taaagaatgt aaatctataa
    21001 aaaaatgttg taagagaagg gagaaataat aatgaaagta tgtataccag tagaggagaa
    21061 taaaggattg gatagtaaac catatggaca ttttggttct gctccaattt ttgttgtgtg
    21121 tgatttagaa agtggagaag ttaaatcttt agataatgga gatttagatc atgaacatgg
    21181 aaaatgtcaa ccattaaaag cattgtcagg gacagctgta gatgcagtag ttgttggagg
    21241 aataggacaa ggagctataa ttaaattaaa tggaatggga ataaaagttt acagagcaga
    21301 aggtgatact ataagtgcta atttagactt acttaaaaat ggaaaattag tagaatttcc
    21361 atcagaccat acttgctcac atgacggatg tggacatcat taaaaaaaaa cagctgatga
    21421 aatatatact tcatcagcta ttttttcttt taataaatac gattttattc ttttaaaacc
    21481 aaaatttaga tttttatgtt ttttgtagta tccttaataa tatttcaagt ttacaagttt
    21541 actactttta gatttttttt gtatgttttt ctatatagtc aatatcattt aatatgtcat
    21601 tgagttcttt attaagtgtt tttaaatcat caccatctac attgtagttt aaaaatagtt
    21661 cctctacatt atcaatgata gaattgactt ttctagtaac ttcaacaaat gtcttaaagt
    21721 tactactatt tttagcattt agaaattttt ttaaatcctt tgatataaat gatactattt
    21781 catattcatc attaaataga cctctaccaa taggatatgg ttcaattctc tgtaaaaaat
    21841 attggtcttt agcattaata ttataagtat aagatatttc ccaaccgtct cctaaatcaa
    21901 acttgataaa atataatgta ctacttactt ttgatattct tgtggcacca agctgtctta
    21961 aaagaacttc aatcgaatca ccttgaacag tattaatatt catatataca catccccttt
    22021 agtattatta tactatattt tttaaaattt tataattaaa taaacagtag atataataat
    22081 agatataatc ataagtggaa aacctatttt gaaatactcc ttaaaagaga taggatgacc
    22141 gtgtttatta cctatacctg ctagtacaac attagcagat gctcctatta gtgttccatt
    22201 tcctccaaga caagctccaa gagatgttgc ccaccatagt ggcattacat caataccttc
    22261 agcttgcata gtcaaaataa gaggaattag tgttgcaaca aatggaatat tatctaagaa
    22321 agaagagact atagctgaca accataatat caacaacatt gtaaatacaa gatgtccttc
    22381 tgtaagtcca atcaatgctt gagccaattt gtttattatc ccaacttcta ctaatccacc
    22441 aactactaca aataatccca taaagaataa aattgtagac cattcaatac ctgccataat
    22501 ttcatctaca tcttgttttc ctattaaaag cattatagat gctcctgtca gtgctacaac
    22561 agaagaatct atgtggattg tactgtgaaa cataaaacca aaaagtatga atgctattaa
    22621 tataaggctt tttataagta gaggtttatc tttaacagat tttttttcat ctagttttaa
    22681 tattgcattt ttagctcttt cattcacaac aagttctttt ccataaataa atctaaagca
    22741 tattatagtt atagcaagta ttactataac agcaggacct aaatttatta caaaatccat
    22801 aaaactaaga ttggcagcac taccaatcat aatatttgga gggtctccta taagagtagc
    22861 tgttcctcct atatttgaag ctaaaatctg tgttattaaa aatggaactg gattaagtcc
    22921 taatatttgt gtaataacta tagtcattgg tccaataagt aagacggttg taacattatc
    22981 taatacagct gataaaatag ctgttataat agcaaaacaa atcattatct tccatgggtc
    23041 acctttggct ttctttgcag tccagatagc tatatattca aataaccccg agtttttgac
    23101 aacagctaca aatagcatca taccaactaa tacaccaata gtattgaaat ctatatggct
    23161 taatccttca tcaagtgtaa gtatattgaa tattatcatt aatagtgcac caccaacagc
    23221 tgctacggat ctgtttacct tttctgtaat aatagctgcc ataactatta aaaatataca
    23281 tatagctatt atttgttgaa attccataat ataagtacct ccatttgtat tattttgtgc
    23341 ctaatgctag tactatatat agtattactt ttttattgtt ttttcaatgg atgtatgaaa
    23401 gtatattatt taacaaagtt tttggaaaat tgacagaatt taaagaaaat ttttgttatt
    23461 taaataaatt ttaaaattat tccattgata ataatattaa acgacaaacg aaaaaatata
    23521 ccctttaaac tagaatttat tgtatctaat aacaattata aaatattaaa tatatctata
    23581 ttataaaaac aataaaaaaa ggtttgattt gaatataaaa ctgcaatata ttaaaaaaat
    23641 tat
//
LOCUS       DAEHWM010000062        23531 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.063, whole genome shotgun sequence.
ACCESSION   DAEHWM010000062 DAEHWM010000000
VERSION     DAEHWM010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23531)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23531)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23531
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.063"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            144..1055
                     /locus_tag="KNP36_002444"
     CDS             144..1055
                     /locus_tag="KNP36_002444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874307.1"
                     /translation="MNNLLFLIGVIALSNGNISIFDDKNKSKGNNRVRKNKKNANDKL
                     SQSTHGNLRFDANDIKRGLRLMDLSEEDLEMGMEIITRTKKYMSRDERKILIKIESVL
                     DLVRGIKKLNNIDMVDTEDETDFFRKMDSDDKKNMMIKEIIDVFPEKRKNSVEKAIGM
                     KKKIDLFAELFLPDDFGEGGFSLSSLANINNLGSMNNLKLLGSLLRGDDSNNDDEDNN
                     DELNYEDEELDCEDKELDDDYDELTDEGEMEDNEDELVEDKNTGYENIENDEDIVYDE
                     ELYNINEQESEYNYNEKNTKTRAKKKR"
     gene            1170..1350
                     /gene="ssrS"
                     /locus_tag="KNP36_002445"
     ncRNA           1170..1350
                     /ncRNA_class="other"
                     /gene="ssrS"
                     /locus_tag="KNP36_002445"
                     /product="6S RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00013"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00013"
     gene            1533..2750
                     /gene="cdeC"
                     /locus_tag="KNP36_002446"
     CDS             1533..2750
                     /gene="cdeC"
                     /locus_tag="KNP36_002446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exosporium morphogenetic protein CdeC"
                     /protein_id="HBF0874308.1"
                     /translation="MQDYKKNKRRMMNQPMSTMNEEEVYTDEINSEDMRGFKKSHHHN
                     GCNTDNKCECHDDCNPCNPCNPCKPNPCNPCKPNPCDDNCGCHDNCKCDCEPCEMDSD
                     ECFENKCGPECCNPISPRNFSVSNAVPFAIEANRIFDTMQFQTFTDATGPNGEPLTFE
                     TEVVEVFGSVPSAGQASVTIEKICLSNDGIVIDTGMTTLEDFDLDPLGDIVGRNCETT
                     FEFAVCGERNAECCRQGKGKSVAYKQRGLTVAVRNLVLELRGRCGCTEFVALAFPAVR
                     AGGGCKRRVDYVEFTFNTLSAPICLPADGRAVTLRQEYQTNLTVDCIGKSILKLECNE
                     CCEPFYELIIPNDIDLVLCLQETVSTLISEQIVVLASPNPIQPRLVDTFSKVCDFSQC
                     GPNHGSGKPSCHR"
     gene            complement(2851..4173)
                     /locus_tag="KNP36_002447"
     CDS             complement(2851..4173)
                     /locus_tag="KNP36_002447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HBF0874309.1"
                     /translation="MKVPYLVLSTVILFISNFIVRIFGFLYKIFLSRALGETGLGIYH
                     MIFNFLMICLAVTTTGIPTALSCLVAKRKALNDRHNTNALFISTLYISFFVALIISIV
                     ASFNSSFLSLKFLKDAKLNLFILAVCPAIVIITLSNVLRGYYYGIKNVKIPAIGQIIE
                     QIGKILFVFLLVMYINNKSMNCYIALLGISIGELSNIIFMLICLWRDSSFDNRYIISI
                     KDFYNSSMETLKMSIPITCNRMSNILLQSISSMMIPSRLALSGMTYQQSLSMYGIVSG
                     MVMPFIFLPFTVGSALIVNLIPTISQEMALRKRKSVIKKIKYSILLTLFVGILSSIFF
                     YFFGKDLCILVFKNTLAGEYLKAMFLVPLFMSLNQTLSGILHSIRKELASSINTITGM
                     LIQLIALYVFLPIPGLNIYAYIYTMTIVSIFTCLLHTIVLFKSLKSIR"
     gene            complement(4224..5018)
                     /locus_tag="KNP36_002448"
     CDS             complement(4224..5018)
                     /locus_tag="KNP36_002448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphatase HisJ family protein"
                     /protein_id="HBF0874310.1"
                     /translation="MFYDYHMHSSFSTDGKSTMEEMVKKSIELGLEEICFTDHVDYDV
                     YADDSFSIVYEDYFKSLETLQSKYKDKISIKKGIEFGVQTQLMDTYKKEAHQYPLDFI
                     ICSIHAIDTMDLYLGNYFKDKTQHEVYENYYLYLYNIVKNYKDYSVLGHLDLIKRYAP
                     YDTILDDRLFSDIIEETLKQAIYDGKGIEINTSCYRYNLPDLTPSKYILQMYKDLGGE
                     IITTGSDSHHISQVACEFDYIYSLLKNMGFKYVSKFNKLKPEFIKL"
     gene            5128..6573
                     /locus_tag="KNP36_002449"
     CDS             5128..6573
                     /locus_tag="KNP36_002449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0874311.1"
                     /translation="MEKYRIDLNEKKSTKYIQIFNHIKELIINKELVEHEKLPPIRKL
                     SNFLQVNNTTIVKVYELLENEGYVYKIIGSGTFVSSLNSYKSGIDNRKNKIIVQREDL
                     IHFDNGNPSNDMFPIDSFKNAVNMALSKDGSSIFEYDEGLGSEELREKMVEYLSDGNI
                     KTTKENIQIISGAQQGIDIVCKGLISYSDVVFMEEPSYNGAIEVFKSRGAKIISIPML
                     DDGIDIGILKLKLEKIKPRLIYIMPNFQNPTGISYSTYKKKKLIELAEEHDFYIIEDD
                     FISDFVFESKDNRTIRSYDDKNRVVYIKSFSKILMPGLRIGIVEMPNELLKKVLWAKY
                     SSDISTPGLIQKSMYYYMNNFDWKNYLSHIEKIYTDKYKLAKNLINDKLSGKLKVRKS
                     CGGINFFLELPRGYTSQAFTNFMLNKGVSMLPGTYFFDNLVDDRFFRINIARPSMEEL
                     EKGISIISDNIDEFFCEYKNKLDIKSNKLFY"
     gene            6602..6811
                     /locus_tag="KNP36_002450"
     CDS             6602..6811
                     /locus_tag="KNP36_002450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 domain-containing protein"
                     /protein_id="HBF0874312.1"
                     /translation="MFDKKKLDRINELAKKNKEGILSADEIKEREILRKEYLENFRAH
                     FRSRLDSVKVVSPEEYEQYMKNNKN"
     gene            6831..8225
                     /locus_tag="KNP36_002451"
     CDS             6831..8225
                     /locus_tag="KNP36_002451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBF0874313.1"
                     /translation="MNLKYEFKNAWDFERKENTIEQIMQYSSNYMEFLSKSKTERLSV
                     KEIIKLAKENNYISIDEAMEKGSISCGDKIYVINKEKAVALFVIGKNYIEKGMKIIGS
                     HIDSPRLDLKPNPLYQESNLGFFKTHYYGGIKKYQWTAIPLALHGIVILNDGTKVDIS
                     IGEEDSDPVFCVTDLLIHLAGDQMQKKLSEGISGEALNILIGNMPLEDEEKEPITANI
                     LKILNEKYNIVEEDLLSAEIEVVPAGKARDLGLDRSMVLGYGHDDRVCSYAAVKAILE
                     TEQPEFTSVALCVDKEEIGSKGNTGMHSKFFENTVAELIALEGDYCDIKVRRALANSK
                     VLSADVSAGYDPNFGEAYEKRNSAYMGNGVVLTKYTGSRGKSGCNDANAEFMSEVKRI
                     FNKGNVIWQTAELGKVDQGGGGTIAHILANQGAEVIDCGVGVLNMHAPHEIVSKVDIY
                     EMYKGYKAFFNINL"
     gene            8465..9217
                     /locus_tag="KNP36_002452"
     CDS             8465..9217
                     /locus_tag="KNP36_002452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0874314.1"
                     /translation="MDEKRQKKEMDLEVNSFVPLYQQLYDNIKKQIASGIYKPGDKLP
                     SEGDLCKEFNISRITVRNALNELVKEDILCKKRGKGTYVTIPERIEATCAGNSFTNSC
                     HRINAKPSTKIISVLIKKADKQVAEALSIELEEKVICIKRLRLIDEVPVIFEVDYFRI
                     DYMFLLKEELEDKSLMEVISNNISTLPKRVENIFEVKHSNKEYSDHLKCASNMPLLKV
                     RQSVYTENNDVLYYNEQFIRSDKYKYAVSAEI"
     gene            9243..9656
                     /locus_tag="KNP36_002453"
     CDS             9243..9656
                     /locus_tag="KNP36_002453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0874315.1"
                     /translation="MKKIILASHGDFSKGLLNAVKMIVGDLADCVSSYGLYPGQSASD
                     FALELEKTISEDKECEYIILSDLYGASVCTAMLRLTNLHNVRLFSGMNLNMVLELLTR
                     FSDELTVEDIDQLVEESRRGIQSVTLQIKEEEEVF"
     gene            9660..10403
                     /locus_tag="KNP36_002454"
     CDS             9660..10403
                     /locus_tag="KNP36_002454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane biogenesis protein"
                     /protein_id="HBF0874316.1"
                     /translation="MKKKGILSVFKSKKPIIAMIHLKGDTPEDIFERAKKEITIFEEN
                     GVDGIMLENYYGNYYDLERILEYVSKANLSIPYGVNCLNVDTMGFELATKYNASYIQV
                     DSVVGHVKPRDEATLEEFFKLQRSKCPAYLIGGVRFKYQPVLSENDVEEDLKIGMTRC
                     DAIAVTENATGQETSMEKIELFRKNLGDFPLVIAAGVTLENAKKQLKLGDMAIIGSYF
                     KDNYKDFGDVSVEHVKTFMDEIKKIREEL"
     gene            10403..10873
                     /locus_tag="KNP36_002455"
     CDS             10403..10873
                     /locus_tag="KNP36_002455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0874317.1"
                     /translation="MIKLVRVDHRLIHGQVAFTWTKFLSTDCILIASDDLLKDELRMA
                     GLKMAKPSNVKLVMKSIADSIKALNSGVTDKYNLLILCESVEDVYRLAKEVKAIKSIN
                     LGGTKSDDNRENISKAVHVSKDDIKMIKELDSEGVNVFVQLVPDDDATNVMKLI"
     gene            10890..11648
                     /locus_tag="KNP36_002456"
     CDS             10890..11648
                     /locus_tag="KNP36_002456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0874318.1"
                     /translation="MEFTQVILITLIAFFAYMHSFVGSTMHNRPIVVAPLVGLALGNL
                     HTGIVIGSTLELVFMGAFPVGASNPPDFVSGSIIATAFVILTGQDVSAAVVLAVPIAT
                     LVLLIDNFLMTVVLTWGAHIADRYAEEGNIEGVERVQLLFGIGNKLILAIIVGIGFSL
                     GVPVIEKILSFIPSYVTHGMDVAAGVIPAIGFAMLARMMLNKKTVAFLLLGFILVAYL
                     NITVTGVALFGLAIALIYVNFVGEKEVIVDDNEF"
     gene            11632..12474
                     /locus_tag="KNP36_002457"
     CDS             11632..12474
                     /locus_tag="KNP36_002457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBF0874319.1"
                     /translation="MTTSSKKLETISPDSKITRKDFWKCFRRSLTLDSSWNYERMQNI
                     AYAYMMAPIIRRLYKDDKEKKSKALKRHLEFMSVTPHISTLLVGISGAMEEENAKNKE
                     FDANSINAVKSSLMGPVSGIGDSFFWGTLKLIAAGVGIALASQGNIMGPILFLLIINV
                     PHFIIRYICLDKGFKYGTQFFKDVSGSSIVSKVMEAASMLGLMVIGGMTASNVMLKLS
                     VNVGSGEWAEPIQTYLDQIMPCMLPAMIFGIMYWLLGKKVKTTTILISVMIICIVLAA
                     IGVV"
     gene            complement(12634..13539)
                     /locus_tag="KNP36_002458"
     CDS             complement(12634..13539)
                     /locus_tag="KNP36_002458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0874320.1"
                     /translation="MDFKQLEVFVAVAKHQSFSKAARELFLTQPTVSAHIQNLERELE
                     TVLINRSNKVITLTKSGEILYEHAIYILNNCKRAIYDIKEYSGKIEGIIDIACSSIPE
                     TYILPDFMKSFSMSYPDVKFSISHYDSQYAISEILNERISFGLVGSKINNPQIEYLDL
                     LDDELVLITPSDFKIDNKNNCIDIGELAYLNFIMRKEGSGTRNLILNTLSKNNFPVSK
                     LNVIAHVESNEAIKEMVRLGLGVSFISYISAIDYLNAGKIKCYKIKDVDFTRKFFFIY
                     SKKKTFSPLEDKFLNRLCEYFEIII"
     gene            13901..14635
                     /locus_tag="KNP36_002459"
     CDS             13901..14635
                     /locus_tag="KNP36_002459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874321.1"
                     /translation="MKLKRSLVCVTILGIILVGCHKENTKEKNQVASKATQQKTMTKV
                     QNDVNEIMNKDYKYIIKNMGIPYNTFYYIKPKVLKESNTMQDINTSSYMTLVYPKYTG
                     NDELDGSALYVDINENKVVNVETNSFSSQGISVIDAESSIVIEKSDHEKSAVSLENFR
                     HIDLGEYVGVEDSRINEIVGDANYDLTAYNHEGSKVVKSYRLKEDNKILKKEVLTISI
                     VDNKIKSIKTIESDKIVKIIKGTLLE"
     gene            14846..16027
                     /locus_tag="KNP36_002460"
     CDS             14846..16027
                     /locus_tag="KNP36_002460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin molybdotransferase MoeA"
                     /protein_id="HBF0874322.1"
                     /translation="MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDS
                     PPFDRSPYDGYAYNANSENRNLKVIGTLYAGDVFNRVLNKNEAVKIMTGGKIPQGANC
                     VIKKEDVTVISDMITLNIKLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLG
                     ISKVTVYDDLKVGILNTGTELQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNC
                     SDDILELEKKVKNMLQSVDFLITTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGA
                     CYVGTLGEKLLFGLSGNPHAAIVVFDNVIVPVIEYLTYKKGTHHIKAIFKGEFNKLSN
                     KDRFVSGKLYTSEGKLYVELNDKKDAKARLSATLRSNCMIKIKKNETIKENQLVDVVI
                     R"
     gene            16011..16583
                     /gene="mobB"
                     /locus_tag="KNP36_002461"
     CDS             16011..16583
                     /gene="mobB"
                     /locus_tag="KNP36_002461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-guanine dinucleotide biosynthesis
                     protein B"
                     /protein_id="HBF0874323.1"
                     /translation="MLLLDSFMKGHNFMYNILSVVSYSGVGKTTLIEGIIKELNKKGY
                     RVGVIKHTCHDFDMDEEGKDTYKHRKSGARKVCIISDKRVAYIEELKEKNPLYKMIQL
                     YEDMDLIIIEGYKNYRFKRLEVTRKGKYEDILSNKSDLIGIVSDIEYKLNIEQFNLND
                     YKNISKYIESCIKNEILSISNVEIKNILKE"
     gene            16702..16977
                     /locus_tag="KNP36_002462"
     CDS             16702..16977
                     /locus_tag="KNP36_002462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0874324.1"
                     /translation="MKKILVACGAGIATSTIVCDRVERLVKENNIQAEVEQCKIAECS
                     TKQEGADLIVSTTILPTTYDIPTIKATGYITGINTTALDKKILNALK"
     gene            17220..18920
                     /locus_tag="KNP36_002463"
     CDS             17220..18920
                     /locus_tag="KNP36_002463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874325.1"
                     /translation="MIKQFVKYYKPYKKIFTLDLIAAFLFSLCDLVYPMITRNIMDDV
                     VPNKNLRMLVVFAVALILIFIAKAGLNYFMQYWGHVIGVDMQADMRNEVFTHLQRLPN
                     TYFDNNKSGVTMSRIVNDLMDITELAHHGPEDLFISIVMLVGSFFILIDINIPLTLII
                     FAILPFIIWFAIAKKDKMNIAFMKSRVTIGDVNATLENSIAGMKVTKSFCTEKEELNK
                     FVRSNKLFRRARQDSYKVMAEYYSGMNLYMDILEWVVVIAGGYFTYIGKITLGDFAAY
                     ILYVKMFIQPMKKLINFTEQYQNGMTGFKRFIEIMEQDHQKEAKNPIELENVKGDIEI
                     ENISFTYEDKTQVLDNLSLSIKAGKTIALVGPSGGGKTTLCNLLPRFYEFDKGDIKID
                     GKSIKDVSLKSLRKNIGIVQQDVFLFTGTIRDNILCGNPNATDEEMIAAAKKARIHDF
                     VETLPDGYDTYIGERGVKLSGGQKQRISISRIFLKNPPIIILDEATSALDNVTEREIQ
                     ESLEELSKDRTNLVVAHRLTTIKNADEIIVLTDKGIEERGTHEELVNKNGVYSRLHNN
                     "
     gene            19283..20470
                     /locus_tag="KNP36_002464"
     CDS             19283..20470
                     /locus_tag="KNP36_002464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874326.1"
                     /translation="MEAITAFCLVLVSLTIGDIVSAKTKAFVPSVFVSAIIFIVGFWT
                     FFPENIVDLAALGTPLAQLGMLLLITHMGTMMSIKELAGQWKTIVIALAGIVGICVGA
                     LALGTVVFGWDTAVIATPPLTGGLVASIMMADAATAKGLASLSVLAILMYVAQGFAGY
                     PITALMLKKEGKRLLSDFRSGKVTVNTDEEKVKDLPEQKSRFKIIPDLPEKYDTTYMI
                     ILRLGFVAWLAVQFTNLTNEVVSRYVICLIFGVIASELGIVDRKPLNKSGSFGWLMTS
                     LMAFIFAGLAKATPAMLVEMAVPLVGIIIFGVIGMGIFSIIVGKLLGESKEMAFSVSL
                     TSLYGFPPNYILTEEAVKALAETPEEKEFLMDKMLPKMLVGGFTTVTIASVVIAGIFV
                     NLI"
     gene            20530..21693
                     /locus_tag="KNP36_002465"
     CDS             20530..21693
                     /locus_tag="KNP36_002465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0874327.1"
                     /translation="MDIKEITKSYKDYVIKLRREFHENPEKSMEEVRTSKRVKEELDK
                     IGIPYVSAGGTGVIATIKGDNPGKTVALRGDMDALQVVECTDVEYKSKNEGLMHACGH
                     DGHTSMLLGAAKVLNDIKDSINGTVKLFFQPGEEVGKGARAMIQDGAMEGVDSVFGIH
                     LWTDVESGTISVEEGPRMASADFFKITVKGRGGHGSLPHQGVDAVLASSAIVMNLQSM
                     VSREVSPLEPLVVSVGVLNSGTRFNVIASEAILEGTIRLFNPELRKQIPGILERIAKS
                     TAEAYRADAELEYGYLTPAVINDKECSKIATDAAIKLFGEDCITLFEKVTGAEDLAEF
                     MNIAPGALAFVGARNESKGACYPHHHGCFNIDEDALEIGTALYVQYAVDFLNK"
     gene            21844..22647
                     /gene="zupT"
                     /locus_tag="KNP36_002466"
     CDS             21844..22647
                     /gene="zupT"
                     /locus_tag="KNP36_002466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861091.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc transporter ZupT"
                     /protein_id="HBF0874328.1"
                     /translation="MNNVIFAFLITLLAGLSTGIGSCIAFFAKKTNTKFLSISLGFSA
                     GVMIYVSMIEIFPKAQDALTKSMGEKLGSWSTVIAFFIGMAIIAVIDKLIPQEENPHE
                     IKKMENIEEKNIKKNKSLLRTGIFTAMAIAIHNFPEGLATFISALDDVTIAIPIAIAI
                     AIHNIPEGISVSVPVYYATGDKKKAFYYSFLSGMSEPLGAIIGYVLLRNFLNDITLGI
                     VFAIVGGIMVFISLDELLPSAREYGEHHLSIYGLIAGMGVMAISLLLFK"
     gene            22742..23302
                     /locus_tag="KNP36_002467"
     CDS             22742..23302
                     /locus_tag="KNP36_002467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HBF0874329.1"
                     /translation="MSAMEKKIKFKFDWYSSPDKIEKWLEDIEAKGYNLYKINKFGGI
                     FYFHKGSPRKIKYTVDYYYDVENNYFDEHKSNGWNLVFRSIGSFMGTSAWYIWSKEYK
                     DIPPKLYSDSDKTNKVKSILFMNMFIFFMLVVIFIYLLNIEIRNLYSGYGASVTAIVL
                     QIILLILYAVQLYRRLMYYLRLKKFK"
BASE COUNT         9234 a         2517 c         4168 g         7612 t
ORIGIN      
        1 aagtggtgaa ttgtgagtga tatataatat aaataaaaat tcttatagat aatatatatg
       61 cactgagctt taaaaatgga acattaaaat atgaaaaaca tactttaata tagggcaatt
      121 atataatata agggggaatt gtcttgaata acttactatt tttgattgga gtgattgcat
      181 tgagtaatgg taatatctct atatttgatg ataaaaataa atcaaaagga aataatagag
      241 ttagaaaaaa caaaaaaaat gcaaatgata aactttcaca gtctacacat ggcaatttaa
      301 ggtttgatgc aaatgatata aaaagaggtt taaggctcat ggatttaagt gaagaagatt
      361 tagaaatggg aatggaaata ataacaagaa ctaaaaaata catgtcaaga gatgaaagaa
      421 aaatactaat aaaaatagaa agtgttttag atttagttag aggaataaaa aaattaaata
      481 atatagatat ggtagataca gaagatgaaa cggatttttt cagaaaaatg gatagtgatg
      541 ataaaaagaa tatgatgata aaggaaatta tagatgtatt cccagaaaaa agaaaaaatt
      601 cagttgaaaa agctatagga atgaaaaaga agatagattt atttgcagaa ttatttttac
      661 cagatgactt tggtgaaggt ggatttagtt tgagctcttt ggcaaatata aacaatcttg
      721 gtagtatgaa taatctcaaa ttgttaggaa gtcttttaag aggtgatgat agtaataatg
      781 atgatgaaga caataatgat gagttaaatt atgaagacga agaattagat tgtgaagaca
      841 aagaattgga tgatgattat gatgagttaa cagacgaagg tgaaatggag gataatgaag
      901 atgaattagt agaagataag aacacaggct atgaaaatat agaaaatgat gaagatatag
      961 tatatgatga ggaactatac aacattaatg agcaagaatc cgaatacaat tataatgaaa
     1021 aaaatactaa aactagagct aagaaaaaac gataattaac taaatacata aagaaaaaag
     1081 gaagaaaaag taatgataga ataagattat ctcaattact atataaaacc actttaaaaa
     1141 attcaaaatt tattatataa taataatatg aaatcctgaa acatacgata aggctttttt
     1201 aaattcaacc tacaaatgaa atacgggaga ccgtgtctgg taaattataa catgcctagt
     1261 tagtttggac gttaaaggtt actggcaagt cacccacctg ggagtgccta gggtgtgaat
     1321 ttacttagcc accggtgttt cgggacaaaa aaagtgctac tatttcaaat agtagtactt
     1381 tttttattaa tatgcatttt tctactaaat acgcctaatt attgataaat tcaaaaagca
     1441 agtaacaatt aagattataa aagcatagta ttaattaggc ttcaaaaagc caaagactta
     1501 ataagaatcg cttacaggga gggcaatgaa aaatgcaaga ttataaaaaa aataaaagaa
     1561 gaatgatgaa tcagccaatg tctacaatga atgaagaaga agtgtataca gatgaaataa
     1621 attcagaaga catgagaggt tttaaaaaat cacaccatca taatggatgt aatactgata
     1681 ataagtgtga gtgccatgat gattgcaatc catgcaaccc atgtaatcca tgtaaaccta
     1741 acccatgcaa tccatgcaaa cctaatccat gtgatgacaa ttgtggatgc catgacaatt
     1801 gtaaatgtga ttgtgaacca tgtgaaatgg attcagatga atgttttgaa aacaaatgtg
     1861 gaccagaatg ctgtaatcct atatctccaa gaaacttctc tgtatcaaat gcagtgccat
     1921 ttgcaataga ggctaataga atatttgata ctatgcaatt ccaaacattt acagatgcaa
     1981 caggaccaaa tggagagcca ttaacttttg aaacagaagt agtagaagta tttggttcag
     2041 ttccaagtgc aggtcaagca agtgtaacta tagaaaaaat atgcttaagt aatgatggaa
     2101 tcgttataga cacaggaatg acaactttag aagatttcga tttagaccca ttaggagata
     2161 tagtaggaag aaactgtgaa acaacttttg aatttgcagt ttgtggagaa agaaacgctg
     2221 agtgctgtag acaaggaaaa ggcaaatcag tagcttataa acaaagagga ttaactgtag
     2281 cagttcgtaa tttagtacta gagctaagag gtagatgtgg atgtacagag ttcgttgcat
     2341 tagctttccc agcagttaga gcaggaggtg gatgtaagag aagagttgat tatgtagaat
     2401 ttacttttaa cacactttca gcaccaatat gcttgccagc tgacggaaga gctgttactt
     2461 taagacaaga atatcaaact aacttaactg tagattgtat aggaaaatct atattaaaat
     2521 tagaatgcaa cgaatgttgt gaacctttct atgaattaat tataccaaat gatatagatt
     2581 tagtactttg cttacaagaa acagttagca cattaataag tgaacaaata gtagttttag
     2641 catcaccaaa tccaatccaa ccaagacttg ttgatacttt ctctaaagta tgtgattttt
     2701 cgcaatgtgg acctaatcat ggaagtggaa agccaagttg ccacagatag ataggtaaga
     2761 tatatagaca gtttaaatta taaataaaaa tcatctaagg aaggctacca aagtgtataa
     2821 tttacattgg tagccttcac gtttttataa ctagcgtata gattttagtg atttaaaaag
     2881 cactatagta tgtaatagac aagtaaagat tgatactatc gtcattgtgt atatgtatgc
     2941 ataaatatta agtcctggaa ttggaagaaa tacatataaa gctattagtt gaattaacat
     3001 gccagtaata gtatttatac ttgaagctaa ttcttttctt attgaatgta aaatgccaga
     3061 tagagtttga tttagggaca taaatagtgg aactaaaaac atagctttta gatattctcc
     3121 tgcaagtgta tttttaaata ctaatataca taaatctttt ccaaagaaat aaaaaaatat
     3181 tgatgatagt atgcctacaa ataaagtaag aagtatggag tatttgattt ttttaattac
     3241 actcttacgc tttcttagag ccatttcttg tgaaatagtt ggtattaaat ttacaataag
     3301 cgctgaacca acagtaaaag gtaaaaatat aaaaggcatt accatcccac tgacaatacc
     3361 atacatactt aaagattgtt gataagtcat tcctgataat gctaatcttg atggtatcat
     3421 catagaactt atagattgca aaagtatgtt tgacattcta ttacaagtta tgggaataga
     3481 catttttaat gtttccatag aagaattata aaaatctttt atgcttataa tatacctatt
     3541 gtcaaatgat gaatctcgcc ataagcaaat aagcataaat ataatattac tcaactcacc
     3601 gattgatata cctaatagag ctatataaca attcatagat ttattattta tgtacataac
     3661 tagtaaaaaa acaaataata ttttaccaat ttgttcaatg atttgtccaa tagcagggat
     3721 ttttacattc tttatgccat agtaatatcc tcttagtacg tttgaaagag ttattataac
     3781 tatagcagga caaacagcta gtataaatag atttaattta gcatctttta aaaatttaag
     3841 tgataaaaaa gaactattga aagatgcaac tatagatata attagtgcta cgaaaaatga
     3901 tatatataaa gttgatataa ataaagcatt agtattgtgt ctatcgttta aagcttttct
     3961 ctttgcaact agacaactaa gtgcagtagg tatacctgtt gttgtaacag ctaagcaaat
     4021 catcaaaaag ttaaaaatca tatgatagat acctaaacct gtttcaccta gtgctcttga
     4081 taagaatatt ttatataaaa aaccaaatat tcttacaata aaattggata taaataaaat
     4141 aactgttgat agtactaaat aaggtacttt caaaaaaatc acctccttat cttttaaata
     4201 tattcacaag gaggtgtaaa aatttataat tttataaatt ctggtttcaa tttattaaat
     4261 ttagatacat atttaaatcc catatttttt agtaatgaat atatgtagtc aaactcacat
     4321 gcaacttgac ttatatgatg tgaatctgaa cctgtggtta tgatttcccc tcccaagtct
     4381 ttatacattt gaagtatata cttagatggg gttaggtctg gaagattata tctataacaa
     4441 gaggtattta tctcgatacc tttgccatca taaatagctt gtttaagagt ttcttcaatt
     4501 atatcagaaa atagtctatc atctaaaata gtgtcataag gtgcatacct tttaatcaaa
     4561 tctaaatgac ctaagacaga gtaatcttta taattcttaa caatattata taaataaaga
     4621 tagtaatttt cataaacttc atgttgagtt ttatctttaa aataattacc aaggtataag
     4681 tccattgtat ctatagcatg gatagaacat attataaagt ccaatggata ttgatgtgct
     4741 tcctttttgt atgtatccat taattgagtt tgaactccaa attcaattcc tttttttatt
     4801 gatattttat ctttatattt gctttgaaga gtctctaaac tcttaaaata atcttcgtag
     4861 acaattgaaa aagaatcatc agcatataca tcatagtcaa catggtctgt gaaacaaatt
     4921 tcctccaaac cgagttcaat agattttttt accatttctt ccattgtaga ttttccgtct
     4981 gtagagaaac ttgagtgcat gtgatagtcg taaaacataa atatttcccc tttttataaa
     5041 aattttggta ttatatatac atactaaata atatcaaata tacataaaag catcaataaa
     5101 atataaatac aatgagcggt gataaatttg gaaaaataca gaatagattt aaatgagaaa
     5161 aaatcaacta aatatataca gatatttaat catataaaag aattgataat aaataaagag
     5221 ttagtagaac atgaaaaatt gcctccaata agaaaactat caaatttttt acaagtaaat
     5281 aacactacta tagttaaggt atacgagctt ttagaaaatg aaggatatgt atataaaatt
     5341 atagggagtg gtacttttgt atcaagttta aattcttata aaagcggtat agataacagg
     5401 aaaaataaga ttattgtgca aagagaagat ttaattcatt ttgacaatgg gaatccatct
     5461 aatgatatgt ttcctatcga ttcatttaaa aatgctgtaa atatggcatt atctaaagat
     5521 ggtagttcaa tatttgaata tgatgaaggt cttggctctg aagaattaag agaaaaaatg
     5581 gtagagtatc taagtgatgg aaatataaaa actactaagg aaaatattca aataatatca
     5641 ggtgctcaac aaggtataga tatagtttgt aaaggactta taagttattc agatgttgtt
     5701 tttatggaag aaccttctta caatggagca attgaagtgt ttaaaagtag aggtgcaaaa
     5761 ataatatcta tacctatgtt agatgatgga attgatatag gtattttaaa attaaagttg
     5821 gaaaaaataa aaccaagact tatatacatt atgcctaatt ttcaaaatcc aactggaata
     5881 tcttactcaa catataaaaa aaagaaattg atagaattgg cagaagaaca tgatttttat
     5941 ataatagaag atgattttat aagtgatttt gtttttgaat caaaggacaa tagaacaatt
     6001 agaagttatg atgataaaaa tagagtagta tatataaaaa gcttttcaaa aatacttatg
     6061 ccaggtctta ggataggaat tgtagaaatg ccaaatgagt tgttaaaaaa agttttatgg
     6121 gctaaatatt catcagatat atcaacacca ggtttaattc aaaaatcaat gtattactat
     6181 atgaataatt ttgattggaa gaattatttg agtcatatag aaaagatata tactgataag
     6241 tataaattgg caaaaaactt gattaatgac aaattgagtg gtaaattaaa agttagaaaa
     6301 tcttgtggag gaataaactt ttttttagaa ttaccaagag gatatacatc tcaagcattt
     6361 acaaatttta tgttaaacaa aggagtgtca atgcttccag ggacttattt ttttgacaat
     6421 ctagtggatg atagattctt taggataaat atagctcgcc caagcatgga agaactagaa
     6481 aagggaatat ctataataag tgataatata gatgagtttt tttgtgaata taaaaacaag
     6541 ttagatataa aaagcaataa attattttat taaataaata gaggtttttt aggaggaaaa
     6601 aatgtttgac aagaagaaat tagataggat taatgaatta gcaaagaaaa ataaagaggg
     6661 aatcctttct gctgatgaaa tcaaagaaag agaaatttta aggaaagaat atttagaaaa
     6721 ctttagagcc cactttagat caagactaga tagtgtcaaa gtagtttcac cagaagaata
     6781 tgagcaatac atgaaaaaca ataaaaatta gaacttagta ggaggaaaat atgaacttaa
     6841 agtacgaatt taagaatgct tgggattttg aaagaaaaga aaatactatt gaacaaatta
     6901 tgcaatattc tagcaattat atggagtttt taagtaagtc aaagactgaa agactttcag
     6961 taaaagaaat tataaaattg gctaaagaaa ataactatat ttcaatagat gaagctatgg
     7021 aaaaaggaag cataagttgt ggtgataaga tttatgttat aaataaagag aaggcagtag
     7081 cactttttgt aataggtaaa aattatatag aaaaaggtat gaagattata ggaagccata
     7141 tagattcgcc aagattagat ttaaaaccaa atccactgta tcaagagagt aatctaggtt
     7201 tttttaagac tcattattat ggtggaataa aaaaatacca atggacggct attccacttg
     7261 ctttacatgg tatagttata ttaaatgatg gaacaaaagt ggacatatct attggggaag
     7321 aagatagtga cccagtattt tgtgtaactg atttattgat tcatttggct ggagaccaaa
     7381 tgcaaaagaa actatcagaa ggaattagtg gagaagcttt aaatatatta attggaaata
     7441 tgcctttaga agatgaagaa aaagaaccta taacagcaaa tatattaaag attttaaatg
     7501 agaaatacaa tatagttgaa gaagatttat taagtgctga aattgaagta gttccagctg
     7561 gtaaggctag agatttaggg cttgataggt ctatggtgtt gggatatggg catgatgata
     7621 gggtatgttc atatgctgct gtaaaagcta tactagaaac tgaacaacca gaatttactt
     7681 cagttgcatt atgtgtagat aaagaagaaa ttggttctaa agggaataca ggtatgcact
     7741 caaagttttt tgaaaatact gtggctgaac tgattgcttt agaaggagat tattgtgata
     7801 ttaaagtaag aagagcttta gcaaatagta aggtattatc agctgatgtt tctgctggat
     7861 atgacccaaa ttttggagaa gcatatgaaa agagaaattc ggcatatatg ggaaatggag
     7921 tagttttaac taagtataca ggttcaagag gaaagagtgg atgtaatgat gctaatgctg
     7981 aatttatgtc agaagtaaag agaattttta ataaaggaaa tgtaatatgg caaactgctg
     8041 aacttggaaa agtagaccaa ggaggaggcg gaactatagc ccatatattg gcaaatcaag
     8101 gtgcagaggt tatagactgt ggtgttggag ttttaaatat gcatgcacca catgagattg
     8161 tctctaaagt agacatatat gaaatgtata agggatataa ggcatttttt aatataaatt
     8221 tataagtaaa aatataaatg taataagtga ataaaggctg ttgtataaac aatttaatct
     8281 gttgtacaac agtcttattt ttatgtaaaa atagcaattt gtcacactag agaaaataaa
     8341 agaaaatact gtcaaattaa aaattattta aaaaaaaatt gacaacgatt tcatcttgtt
     8401 ataatatgta ataaagaact tgttatataa tgttataaaa atgttacata gggaggtgag
     8461 caaaatggat gaaaagagac aaaaaaaaga aatggattta gaagtaaatt cctttgttcc
     8521 tttatatcaa caactatatg acaacataaa aaaacaaata gcatctggca tatataaacc
     8581 aggagataaa cttccatctg aaggagactt atgtaaagaa tttaatataa gtcgtataac
     8641 tgtgagaaat gcacttaatg aacttgtaaa agaagatata ttatgtaaaa aacgtggtaa
     8701 agggacttat gtaacaatac cagagagaat agaagcaaca tgtgcaggaa atagttttac
     8761 taattcttgt catcgtatta atgcaaaacc aagtaccaaa ataatctctg ttttaataaa
     8821 aaaagcagat aagcaagtag ctgaagcttt aagtattgaa ctagaagaga aggtaatatg
     8881 tattaaaaga cttagattaa tagatgaagt acctgttatt tttgaagttg actattttag
     8941 aatagattac atgtttttat taaaagaaga attagaagat aaatctttaa tggaggttat
     9001 atctaataat ataagcacat tacctaaacg agtagaaaat atatttgaag taaaacattc
     9061 aaacaaagaa tattctgacc atcttaaatg tgcaagtaat atgccactat tgaaagtaag
     9121 acaatcggtg tatacagaaa ataatgatgt cttatattac aatgagcaat ttataagaag
     9181 tgataagtac aaatatgcag tatcagcaga aatataatct ataatttagt aggaggatga
     9241 gtatgaaaaa gataatatta gcatctcatg gagacttttc aaaagggctt ttaaatgcag
     9301 taaaaatgat agtaggagat ttagcagatt gtgtcagttc gtatggtttg taccctggac
     9361 aaagtgcttc agattttgct ttagaattag aaaaaacaat atcagaagat aaagaatgtg
     9421 aatatataat tttatctgac ttatatggag caagtgtatg tacagcaatg ttaagattaa
     9481 ctaatctaca taatgttagg ttattttctg gaatgaattt gaatatggta ttagaacttc
     9541 ttacaaggtt ttctgatgaa ttaacagttg aagatataga ccaattagtg gaagaatcta
     9601 gaagaggaat acaaagcgtg acattacaaa ttaaagaaga agaagaggta ttttagttta
     9661 tgaaaaaaaa gggaatatta tcagtattta aaagtaaaaa accaattata gcaatgatac
     9721 acttaaaagg agatactcca gaagatatct ttgaaagagc taaaaaagag attacaatct
     9781 ttgaagaaaa tggtgtagat ggaataatgt tagaaaatta ctatggtaat tattatgatt
     9841 tagaaagaat acttgaatat gtatcaaaag ctaatttatc aataccatat ggagtaaact
     9901 gtttaaatgt tgatactatg ggatttgaac tggcaacaaa atataatgct agttatatac
     9961 aggttgattc tgtagtaggt catgttaaac ctagagatga agctacttta gaagagtttt
    10021 ttaaattaca acgttcaaaa tgtccagcgt atttaattgg aggcgtacgt tttaaatatc
    10081 agccagtatt atcagaaaat gatgttgaag aagatttaaa aataggaatg acaagatgtg
    10141 atgctatagc agttacagaa aatgctacag gtcaagaaac atcaatggaa aaaatagaac
    10201 tgtttcgtaa aaatttagga gacttcccat tggttatagc tgctggagtt acattagaaa
    10261 atgcaaaaaa acagcttaaa ttaggagata tggcaataat aggaagttac tttaaagata
    10321 attacaaaga ttttggggat gttagtgtag aacacgtaaa aacattcatg gatgaaatca
    10381 aaaaaattag ggaggaatta taatgattaa attagtaaga gtagaccaca gacttataca
    10441 tggacaagta gcatttacat ggacaaagtt tttaagtaca gactgtatat tgatagcaag
    10501 tgatgactta ttaaaagatg aattaagaat ggcaggactt aaaatggcta aaccatctaa
    10561 tgttaagtta gtaatgaaaa gcatagcaga ttctataaaa gcacttaact caggtgttac
    10621 tgataaatac aacttattga tactttgtga atctgtagaa gatgtttaca gacttgctaa
    10681 agaggtaaaa gctattaaat ctataaacct tggtggaaca aaatcagatg ataatcgtga
    10741 aaatatatct aaagcagtgc atgtatcaaa agatgatata aagatgatta aagagttaga
    10801 ttcagaaggc gtaaatgtat ttgtacaatt agttcctgat gatgatgcta caaatgtaat
    10861 gaaattaata taattttagg gggatgaaaa tggaatttac acaagttatt ttgataactc
    10921 taattgcatt ctttgcatat atgcatagtt ttgtaggttc tacaatgcat aatagaccta
    10981 tagttgttgc accacttgtt ggtttagcac taggtaatct tcatacaggt atagtaatag
    11041 gttcaacatt agaattagta tttatgggtg catttcctgt tggggcaagt aatcctcctg
    11101 attttgtgtc tggttctatt attgccacag cgtttgtaat attaacgggt caagatgtat
    11161 cagcagcagt tgtacttgca gttcctatag caactctagt attgcttata gataacttct
    11221 taatgacagt agtacttaca tggggagctc atattgctga ccgttatgca gaagagggga
    11281 atattgaagg cgtagaacgt gtgcaattat tatttggtat aggaaataaa ttaatattag
    11341 caataatagt aggtatagga ttttcattag gtgttccagt aatagaaaaa atactttcat
    11401 ttataccatc atatgtaact catggaatgg atgttgcagc aggcgtgatt ccagcaatag
    11461 gttttgccat gttagctaga atgatgctta ataagaaaac agtagcattt ttattattag
    11521 gatttatatt ggttgcttac ctaaacataa cagtaacagg agttgcattg tttggattag
    11581 caatagcttt aatatatgtt aactttgtag gagagaagga ggtaatagta gatgacaacg
    11641 agttctaaga aattagagac aatttcacca gatagtaaaa taacgaggaa agacttttgg
    11701 aaatgtttta gaaggtcatt gacattagat tcatcttgga actacgaacg tatgcaaaat
    11761 atagcatatg catacatgat ggcaccaata atccgtagat tatataaaga tgataaagaa
    11821 aagaaatcta aggctttaaa aagacattta gaatttatgt cagttactcc tcatataagt
    11881 actcttttgg taggtatatc tggagctatg gaagaagaaa atgcaaagaa taaagaattt
    11941 gatgctaata gtataaatgc tgttaaatca agtttaatgg gtccagtttc tgggatagga
    12001 gattcatttt tctggggaac attaaagctt atagcagctg gggttggtat agctttagct
    12061 tctcagggta acataatggg accgatttta ttccttttaa taataaatgt tcctcatttt
    12121 attatacgct atatatgtct agataaagga tttaagtatg gaactcaatt ctttaaagat
    12181 gtgagtggtt caagtatagt ttcaaaagtt atggaagcag cttcaatgtt agggcttatg
    12241 gtaattggag gtatgactgc atctaatgta atgttaaaac ttagtgttaa tgtaggtagt
    12301 ggagaatggg cagagcctat tcaaacttac ttagaccaaa taatgccatg tatgcttcca
    12361 gctatgatat tcggtattat gtattggtta ttaggaaaaa aggtaaagac aactacgata
    12421 ttaatttcag ttatgattat ttgtatagta ttggctgcta ttggagtagt ataaataaaa
    12481 aaatcccaag ttcatttgaa cgagggattt tttgactaaa ttaaataaaa aagaaagatg
    12541 gttcataata atttataagc atttatgtga tagttataat tagcttatta attagttata
    12601 aactcaaaat taagcactac tttattaaag ttattatatt ataatttcga aatactcaca
    12661 taatctgttt agaaatttat cttctaatgg ggaaaaagtt ttctttttag agtaaatgaa
    12721 gaaaaacttt ctagtaaaat caacatcctt tattttataa cattttattt tacctgcatt
    12781 gagataatcg atagctgaaa tgtacgatat aaaggacact ccaagaccta atctaaccat
    12841 ttccttaata gcctcatttg attctacatg agcgattaca tttaatttac ttactggaaa
    12901 gttattttta ctaagtgtgt ttagtattaa gtttcttgta cctgaccctt cttttctcat
    12961 aataaaattt agataagcca attctcctat atcgatacaa ttatttttat tatcaatttt
    13021 aaaatctgaa ggagtgataa gaacaagttc atcatctaat aagtctaggt actctatttg
    13081 aggattattg attttagaac caactaatcc aaagcttatt cgttcattta aaatttctga
    13141 tatagcatat tgagaatcat aatggcttat ggaaaatttt acatctggat aactcataga
    13201 aaaactcttc ataaaatcag gtaaaatata agtttcaggt atggaactac atgctatatc
    13261 tataatacct tctatttttc ctgaatattc ttttatatca taaattgcac gtttgcaatt
    13321 attcaatata tatatagcat gttcataaag aatttcacca gattttgtga gtgtaataac
    13381 tttgttgctt ctatttataa gaacagtttc tagctctctc tctaaattct gtatgtgtgc
    13441 gcttacagta ggttgagtta aaaaaagttc tcttgcagcc tttgaaaaac tctgatgttt
    13501 tgcaacagca acaaatactt caagttgttt aaaatccatt atttaatcct ccttaaatta
    13561 tctaaaacta ttataacata tttgataaat taatagtcaa aggtgatttt taaaatagaa
    13621 aacctttaaa tattcatgga gtttttgatt gtttaggaat aatttggtat aatgttgtaa
    13681 ggtacttaca ataaaaatat cgtaaattga attttcaaaa ttcaacttta aagtgttttt
    13741 tattacagaa aaattacaat tagcttctta atcttattaa attcaaataa atattatata
    13801 attattttat aatataataa atataattat tgaaaaaaga gataactgta aattgagata
    13861 tagataaata ctataaaatt taagaaagga ggattgattt atgaagttaa aaaggtcatt
    13921 agtttgtgta actattttag gtattatact tgttggatgt cataaagaaa atactaaaga
    13981 gaaaaatcaa gtagcaagta aagcaacaca gcaaaaaact atgacaaaag ttcaaaatga
    14041 tgttaatgaa attatgaata aagattataa gtacattata aagaatatgg gtatacctta
    14101 taatacattt tattatataa aacctaaagt tttaaaagaa tcaaatacaa tgcaagatat
    14161 aaatacatca agttatatga cattagttta tccaaaatat actggaaatg atgaactaga
    14221 tggaagtgct ttatatgttg atattaacga aaataaagtt gtcaatgttg aaaccaattc
    14281 tttctcatca caaggtatat cagtcattga tgctgaatct agtatagtga ttgaaaaaag
    14341 tgaccatgaa aaatcggctg tatcactaga aaattttaga catattgacc tgggagagta
    14401 tgttggtgtt gaagattcca gaataaatga aattgtagga gatgcgaatt atgatttaac
    14461 agcatataat catgaaggca gtaaagtagt taagagttat agattgaaag aagataacaa
    14521 aatattaaaa aaagaggtac ttacaataag tattgtggat aacaaaataa aatctataaa
    14581 aactattgaa agtgataaaa ttgtaaaaat aataaaagga actttattag aataaaatat
    14641 tctaaagcat atgatgctgt ttcaagatag aaggaaattt ctagctggga acagtttttt
    14701 tattagattt ataaaatttg aactgcactt atagataact attagttata attaaatata
    14761 agataaaagt atttccaact tttataatct ataatatatt acatagaaat atcttaaata
    14821 aaaaatatat tggggagtat ttaaaatgat agaattagaa gatgccataa aaattattga
    14881 aaaaaatgtt ttaccaataa acagggtcaa gatagtaaat cttatagatg cagtaaataa
    14941 ggtagttgca gaagatatat attcaacaat tgatagtcct ccatttgata ggtcacccta
    15001 tgatggttat gcatataatg caaattctga aaatagaaat ttaaaggtta tagggacttt
    15061 gtatgcagga gatgtattta atagggtatt aaataaaaat gaagcagtga agataatgac
    15121 tggtggaaag ataccacagg gtgcaaattg tgtaataaaa aaagaagatg taacagttat
    15181 aagtgatatg ataactttaa atataaaatt aaaggaatac gataattaca tatttaaggg
    15241 tgaggatata aaaaaggggc aattgattat taataaaaat cagaatatag gatatgatgg
    15301 tattggagta ttagcaagtc ttggaatatc caaagtaact gtttatgatg atttaaaagt
    15361 tggaattttg aatacaggta cagaactaca agatataaat gagactttag agaatggtaa
    15421 aatatacgat agtaatagat ataccttata ttcaagatta ttaaaacttg gaatacaagc
    15481 agatacaata tgcaattgtt ctgatgatat attggagtta gaaaaaaagg taaagaatat
    15541 gttacagagt gtagattttt taattaccac aggtggtgtt tctgttggag ataaagattt
    15601 aattccagat gtattcaaaa aaataggggc aacagaatta ttttggaaga taaacattaa
    15661 acctggtgga gcttgttatg taggtacatt gggagaaaag ctattatttg gtctttctgg
    15721 taatccacat gcagcaatag tggtatttga taatgtgata gttcctgtta ttgagtattt
    15781 aacatataag aagggaacac atcatataaa agctatattt aaaggagaat ttaataaact
    15841 ttcaaataaa gatagatttg taagtggaaa actatataca agtgaaggta aattgtatgt
    15901 agagctaaat gataagaaag atgcaaaagc tagattatct gcaactctaa gaagtaattg
    15961 tatgattaag attaaaaaga atgagacaat aaaagaaaat caattagtgg atgttgttat
    16021 tagatagttt tatgaaagga cacaatttta tgtataatat attgtcagtt gtctcatatt
    16081 caggagtagg taaaactaca ttgattgaag gcataataaa agaattaaat aaaaaagggt
    16141 atcgtgttgg agttattaaa catacctgtc atgattttga tatggatgag gaaggaaaag
    16201 atacttataa acatagaaaa tctggggcga gaaaagtctg tataatatca gataaacgag
    16261 tagcatatat tgaagaacta aaagagaaga atccattata taaaatgatt caattatatg
    16321 aagatatgga cttgattatc atagaaggat ataaaaatta tagatttaaa agattggaag
    16381 taactagaaa aggtaagtat gaggatattt tatctaataa gtctgatttg ataggtattg
    16441 tcagtgatat agaatataaa ttgaatattg aacagtttaa tttaaatgat tataaaaata
    16501 tatcaaagta catagagtct tgtataaaaa atgaaatttt aagtataagc aatgttgaaa
    16561 taaaaaacat attaaaagaa taattttaag atgttcttct tatataaaat gatataatta
    16621 tttatataaa taaagatata agaaatttat caattttatt ttgagttata aaatattaaa
    16681 gaaattgtag gaggacaata tatgaaaaaa atattagtag cctgtggagc aggaatcgca
    16741 acatcaacaa tagtttgtga cagagtagaa agattggtta aagaaaataa tatacaagca
    16801 gaagttgagc aatgtaaaat tgctgaatgt tcaacaaaac aagaaggtgc tgatttaatc
    16861 gtatctacta ctatactacc aacaacttat gatataccta caataaaggc aacaggatat
    16921 ataacaggta taaatacaac agcattagat aaaaagatat taaatgcatt gaagtagttt
    16981 tgtatttata aaaaaaattt agtattaaat atagagttgt atctttataa aattttaaat
    17041 atagagatat agctcttttt atgttgtttc aagtatacaa ctatatgata taaatcttca
    17101 attttatgaa aaagattgtt attactttgt aagtttataa aagatttaaa gttattgtta
    17161 tgttatacta atttatgggt attttttaga agtactaata aaggagggat ttaatactta
    17221 tgataaaaca atttgtcaaa tattataagc catataagaa aatttttaca ctagacctta
    17281 tagcagcttt tctattttcc ttatgtgatt tagtttatcc tatgataact agaaatataa
    17341 tggatgacgt tgttccaaat aaaaacttaa gaatgttagt agtttttgca gtagcactta
    17401 tacttatatt tatagcaaaa gcagggctta actattttat gcagtattgg ggacatgtta
    17461 ttggtgtaga tatgcaagct gatatgagaa atgaggtatt tacacactta caaagacttc
    17521 caaatacgta ttttgataat aacaaatctg gagtaactat gtctagaata gtaaatgatt
    17581 taatggatat aacagaactt gcacatcatg ggcctgaaga tttattcatt tctatagtaa
    17641 tgttggttgg ttcattcttt atacttatag atataaatat tcctcttacg cttataatat
    17701 ttgctatatt accgtttata atttggtttg caatagctaa aaaagataag atgaatattg
    17761 cttttatgaa gagtagagtt actataggtg atgtaaatgc tactttagaa aatagtatag
    17821 caggtatgaa ggtaactaag tctttttgta ctgagaaaga agagttaaat aagtttgtaa
    17881 gaagcaataa attatttaga agagcaagac aagattctta taaggtaatg gcagaatatt
    17941 actctggtat gaatttatac atggatatct tagagtgggt agttgtaata gctggtggtt
    18001 attttactta tataggaaag attactttgg gtgattttgc tgcttatata ctatatgtaa
    18061 aaatgtttat acaacctatg aaaaaattaa taaactttac agagcaatat caaaatggta
    18121 tgacaggttt taaaagattc atagagataa tggaacaaga ccatcaaaaa gaagctaaaa
    18181 atcctattga acttgaaaat gtaaaaggtg acattgagat agaaaatata tctttcacat
    18241 atgaagataa gactcaagtt ttggataatt taagtttatc tataaaagct ggtaagacta
    18301 tagcattagt tggaccttct ggaggaggaa agactacatt atgtaatcta ttgccaagat
    18361 tttatgaatt tgataagggt gatataaaaa ttgatggaaa gagtataaaa gatgttagtt
    18421 taaaatcatt gagaaaaaat ataggtatag ttcaacaaga tgtattttta tttacaggaa
    18481 ctataagaga taatattctt tgtgggaacc ctaatgctac agatgaagaa atgatagctg
    18541 ctgctaaaaa agctagaata catgactttg tagagacttt gccagatgga tatgatactt
    18601 atataggaga aagaggcgta aaattatcag gtgggcaaaa acaaagaatt tcaatttcaa
    18661 gaatcttttt aaagaatcct ccaataataa tattggatga ggctacatct gctttagaca
    18721 atgtaacaga aagagaaatt caagagtctt tagaggaatt aagtaaagat agaacaaatt
    18781 tagttgttgc acatagattg actactataa aaaatgctga tgaaatcata gtattgacgg
    18841 ataaaggaat tgaagaaaga ggtactcatg aagagctagt aaacaaaaat ggagtatata
    18901 gtaggttaca caataactag tatacaaatt ttacaccata gctaacatac acattaaact
    18961 tacaaacata ggatatatta agattcataa agacaattca ttttatattt ataagatgtt
    19021 ttatgaataa aatgtatcct atgttttatt ttttgcaaat tacatttaat tctctttgta
    19081 agaatagagt taaatagcca atggtcggga taacgttttt acaaaaagaa taatttagaa
    19141 aactaacttt aatttatgga atttatcgaa ttttatgaaa aaaatcgaat tttgacttga
    19201 aatgtttttc aaaagtagta aaataatgga taactataca tacattttat aaaaatatat
    19261 ttattatgag gggggatttt gtatggaggc aataacagct ttttgtctag ttttagtatc
    19321 actgacgata ggagatatag tttcagcaaa aactaaagct tttgttccgt cggtttttgt
    19381 atcagcaatt atatttatag taggattttg gacttttttc ccagaaaata ttgtggactt
    19441 agccgcttta ggaacaccat tagctcaatt aggtatgctt ttgttaataa ctcatatggg
    19501 aactatgatg agtattaagg aattagcagg tcaatggaaa acaatagtaa tagccttggc
    19561 aggaatagta ggaatatgtg taggtgcttt ggcattaggg acagtagtat ttggatggga
    19621 tacagcagta atagctacac ctcctcttac tggagggcta gttgcatcta taatgatggc
    19681 agatgctgct acagcaaaag gtcttgcaag tttatcagta cttgcaattt tgatgtatgt
    19741 tgcacaagga tttgcgggtt atcctattac agcattaatg cttaaaaaag aaggaaaaag
    19801 acttttatca gactttagaa gtggaaaagt aactgtaaat acagatgaag aaaaagttaa
    19861 ggatttacct gaacaaaaaa gcagatttaa gataatacca gacttaccag aaaaatatga
    19921 tacgacatat atgataatac ttagattagg atttgtagca tggttagcag tacaatttac
    19981 aaatcttaca aatgaagttg tatcaagata tgttatatgt ttaatatttg gtgtaatagc
    20041 atcagaactt ggaatagttg atagaaaacc acttaataaa tctggttcat ttggatggtt
    20101 aatgacatca ttgatggctt ttatatttgc agggttagca aaagctacac cagcaatgct
    20161 tgttgaaatg gcagttcctc ttgtaggaat cataatattt ggtgtaatag gtatgggaat
    20221 tttctctatt atagtaggta agcttttagg tgaaagtaaa gaaatggctt tttcagtttc
    20281 gcttacatca ctttatggtt ttccaccaaa ctatatatta actgaagagg cagtaaaggc
    20341 tttggctgaa acaccagaag aaaaagaatt tttaatggat aaaatgcttc caaagatgct
    20401 tgttggagga tttactacag ttacaatagc ttctgtagta atagcaggta tctttgtaaa
    20461 tctaatatag tatttaattg ataaaaagta ttttaaataa gaagaatgtg tactacttgg
    20521 aggtatagaa tggatattaa agaaataaca aagagttata aagactatgt aattaagctt
    20581 agaagggaat ttcatgaaaa tcctgagaaa agtatggaag aagttagaac atcaaagaga
    20641 gttaaagaag aacttgataa aatagggata ccatatgtat cagctggagg tacaggtgta
    20701 attgcaacta taaaaggaga taatccagga aagactgtag cacttagggg tgatatggat
    20761 gctctacaag ttgttgaatg cactgatgta gaatacaaat ctaaaaatga aggacttatg
    20821 catgcttgtg gtcatgatgg tcacacatca atgcttctag gggcagcaaa agtgttaaat
    20881 gatattaagg atagtatcaa tggaactgta aaattatttt ttcagccagg agaagaagtt
    20941 ggtaaaggtg caagagctat gattcaagat ggtgctatgg aaggtgtaga tagtgtgttt
    21001 ggaatacatc tttggactga tgtagaatct gggaccatat cggtagaaga aggaccaaga
    21061 atggcttctg ctgatttctt taaaattact gtaaaaggta gaggtggtca tggttcactt
    21121 cctcatcaag gtgttgatgc agtgcttgca agttcagcaa tagttatgaa tctacaatct
    21181 atggttagta gagaagtaag tcctctggaa ccattagttg tgagtgttgg agttttaaat
    21241 tctggaacta gatttaatgt aattgcgagt gaagctatct tagaaggtac aataaggcta
    21301 tttaatccag agcttagaaa gcaaattcct ggaattttag aacgtatagc aaaatctaca
    21361 gcagaagcat atagagcaga tgctgaatta gagtatgggt acttaacacc agcagttata
    21421 aatgacaaag aatgttcaaa gatagctaca gatgcagcaa ttaagctatt tggagaagac
    21481 tgtataacac tatttgaaaa agtaacagga gcagaagatt tagctgagtt tatgaatata
    21541 gcacctggtg cactagcatt tgtaggagct agaaatgagt caaaaggtgc ttgttatcct
    21601 catcatcatg gatgctttaa tatagatgaa gatgctctag aaattggaac tgctttatat
    21661 gtgcaatatg cagtggattt cttaaataaa taattttaat atactataaa gaaaaagcag
    21721 agactaagtt tatatctctg cttttttatt gtgtatattt tttataaata ttgactatat
    21781 aaaatatata tgatagcata aagaaaatga taatcaatat caattaaaaa gaaggtgatt
    21841 tatttgaata atgtaatatt tgcatttttg ataacattat tggctggttt atctactggt
    21901 ataggaagtt gtatagcatt ttttgctaaa aaaacaaata ctaagtttct ttctataagc
    21961 ttaggatttt ctgctggtgt tatgatttat gtttctatga tagaaatttt tcctaaagca
    22021 caagatgctt tgacaaaatc tatgggagag aaattaggaa gttggtcaac tgtaatagct
    22081 ttttttatag gtatggctat cattgctgtt attgataagc taattccaca agaagaaaat
    22141 ccacatgaaa taaagaaaat ggagaatata gaagaaaaga atatcaaaaa aaataagtct
    22201 cttttaagaa caggtatatt tacagcaatg gctatagcaa ttcacaattt tcctgaagga
    22261 ttagctacat ttatatcagc tcttgatgat gttacaatag ctattccgat agcaattgca
    22321 attgcaatac acaatatacc agaaggtata tctgtatctg taccagttta ttatgccaca
    22381 ggagataaaa agaaagcttt ttattattcc tttttatctg gtatgtctga gcctttagga
    22441 gcgattattg gatatgtact tcttagaaat tttttaaatg atataactct tggaattgta
    22501 tttgcaattg taggaggaat tatggtattc atatcactag atgaattatt gccatcagct
    22561 agagagtacg gggaacatca tttatctatt tatggattga ttgcaggaat gggtgttatg
    22621 gctattagtt tattactatt taaataactt ttaaatatat gattgtaacc taaaattagt
    22681 atcaaaatga tataattatt taaatagatt tttaagctat ttaaaaatat cattttggag
    22741 aatgagtgct atggaaaaga aaataaaatt caaatttgac tggtatagtt cacctgataa
    22801 gatagagaaa tggttagaag atattgaagc taaaggatat aatttatata agataaataa
    22861 atttggagga atattttatt ttcataaggg aagtccaaga aaaataaaat acactgttga
    22921 ttactactat gatgtagaga ataattattt tgatgaacat aaatcaaatg gctggaatct
    22981 tgtatttagg agtattggta gttttatggg tacatctgca tggtatatat ggtcgaaaga
    23041 atacaaagac atacctccta aattatatag tgattctgat aaaacaaata aagtaaagtc
    23101 aattttattt atgaatatgt ttatattctt tatgttagta gtaatattta tatatttatt
    23161 gaatattgaa ataagaaatt tatatagtgg ttatggagca tctgtaactg ctattgtact
    23221 acagattata ttgttgattt tatatgcagt acaattatat aggagattaa tgtattattt
    23281 aaggcttaaa aagtttaaat aaataaaaga aggtgtccta aaattatttt tttaatattt
    23341 taagacatct tcttttgtca gtaagtactg tttttaatta tagtaatttc tgtctttaaa
    23401 ttgaaatatc aaataatagt tgtatgggat tgagtattga taaaaataat ttaaaaatgt
    23461 tatcctaaag tatcagatat acaaaattat ctttaaatat attataaata ttttaattgt
    23521 attaactaga a
//
LOCUS       DAEHWM010000063        23317 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.064, whole genome shotgun sequence.
ACCESSION   DAEHWM010000063 DAEHWM010000000
VERSION     DAEHWM010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23317)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23317)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23317
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.064"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            287..1519
                     /locus_tag="KNP36_002468"
     CDS             287..1519
                     /locus_tag="KNP36_002468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine permease"
                     /protein_id="HBF0874330.1"
                     /translation="MQEREELVLNPVPKEERVGWLAPLFNMLGSNIAISELMVGGTLI
                     LGMTLSNMIITSIIGNLILVAIIMIQGYIGYKEGLNTYVLAKGAFGEIGGKYLISLLL
                     GITSFGWFGVQAGVAGLSVQKIFPSVNLTLVTVILGLFMVVFALYGFKAMAKFNYLVI
                     PPLMILMVWGVFKAFSTYGVEAIYNYTPQTTMSMVEGLNIVVGLVIVGAIISPDQLRY
                     TRRVKDIWIISFLGLGIISLFQQVAAGVMSMGAPTWDITEVLANLGFGWVAFVILILA
                     SWSTNVSNAYSGGLALKTIFPNVKRNVLTLVAGLIGTIIAATGIIFKFQSFLSFLGIA
                     VPAIAGIMWCEYYFIQGRTYKHREGINWIAVISWLIGFAASYYSSKINFLIPPINGIV
                     VSMVIYYILMNCFGIKDK"
     gene            1533..2339
                     /locus_tag="KNP36_002469"
     CDS             1533..2339
                     /locus_tag="KNP36_002469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbon-nitrogen hydrolase"
                     /protein_id="HBF0874331.1"
                     /translation="MGRKVKIGIIQQHSVLGNVKKNIEKAVEMIDDLGKQGADIICLP
                     ELFATGYNLESLGGVKTLELIREHNKYIEESMSEAAKRNNVYLISPYGTLEKGSTHVY
                     NSAVIFDRKGKIMGEYCKNHLWSLEAVYFKGGEKVEVYDADFGRFGVMICYDAGFPEV
                     SRELTLKGSEIIFIPSAWRIQDEDMWDLNVSQRALENTVYTVGVNLVSNDSNLILFGK
                     SKICNPRGTVITQLDTYREKYVLSEIDLDEIKKYREDIPYLKDRKSSYNI"
     gene            complement(2451..3320)
                     /locus_tag="KNP36_002470"
     CDS             complement(2451..3320)
                     /locus_tag="KNP36_002470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0874332.1"
                     /translation="MDLLHLKYFQTVARMEHITKASHKLNIAQPALSKTISSLEKELG
                     VQLFDRKGRYIVLNEYGRLFLKRVDSILDLVESSKKELQDTSLENSGEVKILSPAAAN
                     VLPSLLSNFRKLYPNITFNVSHTLPSSYKKSDFDLYISSSFTKLNSENSITLTCEEIL
                     LGVSINHPLSLKDEVYLSEVSDENFIVITKGENYREVIDILCESANFKPKIAFESDSP
                     YTIYALIKSLQGVGFICGKSWGLSQDPEIKLLHIKDIEFKRYLNLSWFSENYESKAVL
                     LFKNFLINYFKNI"
     gene            3692..5119
                     /locus_tag="KNP36_002471"
     CDS             3692..5119
                     /locus_tag="KNP36_002471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp14"
                     /protein_id="HBF0874333.1"
                     /translation="MKLTKSISSMLCLSLVLSLSPVAYANEISRTTVENTLVGQDRYQ
                     TAVEVSKKGWSSANEAVVVNSESIVDALAVTPFAKLKNAPILLTEKNNLNSQTEKELK
                     RLGVKKVYIIGLSSSVSNDVQKQLESNNLTTDRVGGSDRYQTALSIAKKIEGLKDISE
                     IAVVNGYTGLADAVSIASVAATNGMVILPVSDASGISSFKDFIESKNINKSYIIGSTN
                     AVSDKIKQSLPNSERIGGADRNETNGKVIEKFYTSNKLNNVFVAKDGMKNQNQLIDAL
                     AVGVLASKENSPVLIVGEQLSATQKSVFSNKNATSITQVGSGGNENAFKELKDLQANS
                     NNKRVMYVTNTDKVNIRNDATIEASVIGYLNNGDEVEVLDVLKTGWVEIKYNEGIGYV
                     SGSYLTNNKPDNSNENIKIKYVKEKDGLNVRKGPSTEDEKIGHLSYGSKVETIEMFAT
                     GWVKIKYNGGYGYVSNDYLSDTPVI"
     gene            complement(5196..5465)
                     /locus_tag="KNP36_002472"
     CDS             complement(5196..5465)
                     /locus_tag="KNP36_002472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874334.1"
                     /translation="MKFEYYYLIQDIAGILLAFIGLRMSIIGFRILSMKGLSINTLLI
                     VIKYCLFTIAGLNLLISKFGIRHWIWSVCMLIISIIINPRIKVSK"
     gene            complement(5468..6910)
                     /gene="nhaC"
                     /locus_tag="KNP36_002473"
     CDS             complement(5468..6910)
                     /gene="nhaC"
                     /locus_tag="KNP36_002473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="HBF0874335.1"
                     /translation="MKMNTERKIPSFRYSLLVMLAIIALTSVGIVVFNASITTMFLLS
                     WLIVVPAAMKLGYTNDEIEAFGFEVGKDAFQSNLIILSVGVLIAAWIAAGTIPTVVYS
                     GLTIITPKYFLLTTLIVCSLTSVATGTSWGTLGTSGIAMMSIGTSMGIPLGLTAGAVI
                     SGAFFGDKMSPLSDSTNLAAAVCKTDVITHMKHMFYTTGPAYVICIVLYTVIGFKYSN
                     NTIDYVQINQIKDVLNSNFHIGLVAMIPIIFLLLLLLLQKPPIISILSSAIMGLIIAV
                     FQEGEKIGDVLNYMLSGFTIDTGFVYADKLLNRGGIMSMAETVLLVFVVFVIAGILQK
                     TGFLEVLLQPLITKIGKSRTKLVGSTFIVSYFANAFSSSMMFTSVFVGTLMSPIYKEF
                     KLKPQNLSRIIEDTATLGGPLIPWNSNAVFCAQTLGVSPLEFIPYCFLSWITPIISFI
                     YGVTGFTMLTYTDDEIEELEIFDTAQRRVD"
     gene            complement(6935..8101)
                     /locus_tag="KNP36_002474"
     CDS             complement(6935..8101)
                     /locus_tag="KNP36_002474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0874336.1"
                     /translation="MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAA
                     PCIIDSLKNRLEQEIYGYTTRPDSYNESIVNWLDRRHNWKIKSEWLIYSPGVIPAISL
                     LINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIK
                     DVKLFILCNPHNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMAS
                     ISKEFEKNTITCMAPTKTFNIAGLQSSYVILPDEKDYKLLDDAFTRIDIKRNNCFSLV
                     ATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPEGTYLLWVDFSALGL
                     SDEELESILVQKGKVALNQGNSFGIGGSGYQRINLACPRSMLEEALIRIKNAIN"
     gene            complement(8326..10446)
                     /locus_tag="KNP36_002475"
     CDS             complement(8326..10446)
                     /locus_tag="KNP36_002475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0874337.1"
                     /translation="MKQMELAIVSLKKDAGEIYENQIRQFLGDNLKINLYSFEEGNLK
                     FFKEKLILLSAYLKYDEIVKLSHYDAQIIVPKLTFEKNSIDMISKLEKDKIIYVYNLS
                     KDMAIETISLIHRLGIDNINILPCYPEIEFTPTDAVILTPGEKILPKFKNCEVIDLKY
                     RIIDLSCIVEIATKTKLKHLIKDDLIKKYVEKIIPTSYSTGELLLDANKFERQFDLLL
                     SIIDDGIICTNNDGIIQFYNHMARKILSINANEMIDSFVGDCIKDINFQSILTNKTPF
                     FEKLIKINHIDINLEIKHIQLNVFDGFILKMTKFSQLEKKQAKLRAQLVNSGNISKYT
                     FDDILGSSIQTINTKKIANKMAQSNSSILIIGESGTGKELFAQSIHSASRRKDGPFVA
                     VNCSTFQENLLQSELFGYDEGAFTGAKKGGKIGLFELANNGTIFLDEIGEMDLNSQSK
                     LLRVIQEKQVRRIGSNNVIDIDVRIIAATNRNLKELVSKNMFRRDLYFRLNVLPLKIH
                     PLRERPADIFEIFGSLKYDIPCNFILSEEVKEIFKMYRWEGNVRELRNLGEYFCYLEK
                     DIIEICDLPEYILDTIDSNYSRTVCNKVSDNIKKYQFNIGKDKNIMKYDYNFKRSLDE
                     YIFILDNLKKAYDLKERIGRKSLCKIALEENRFLTEQQIRNMLLELQNFGLVDILVGR
                     GGSIITSKGVEFLKNINRSNKLNS"
     gene            10679..11080
                     /locus_tag="KNP36_002476"
     CDS             10679..11080
                     /locus_tag="KNP36_002476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874338.1"
                     /translation="MKKCLYCNRDIKSPNNKLAIKYDDNMNIYPCRAECKEKIEEYIA
                     KKPTYKFINILEVLLGVGGIFCFLSKWTIAAQVVLGIDALVIFLFPLAGFKMNGKLSM
                     EQTKNQSRSIAISILAFIVIITVLYFKQVGK"
     gene            11123..11416
                     /locus_tag="KNP36_002477"
     CDS             11123..11416
                     /locus_tag="KNP36_002477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="HBF0874339.1"
                     /translation="MEERKLAPNNEREALIKRLKRIEGQVKGIQKMVEQERYCVDILV
                     QISAIRSAINRVGTIILENHIKGCVAESIKHDDADKTEEMIKELMDTINKFTK"
     gene            11431..11871
                     /locus_tag="KNP36_002478"
     CDS             11431..11871
                     /locus_tag="KNP36_002478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SoxR reducing system RseC family protein"
                     /protein_id="HBF0874340.1"
                     /translation="MNQQGFIMEIVDDRTAKLKMQRHSACAACGKCATTNSAESKEIL
                     VEVDNTIGAKVGDHVEVSMDNMNVLKAAVMAYIIPLIALLVGTIGTYYILGAIGMTTG
                     VEAISGLVGICLTIICYLYLKKNDKKFRDSREFIPVITRILIDL"
     gene            complement(11963..12436)
                     /locus_tag="KNP36_002479"
     CDS             complement(11963..12436)
                     /locus_tag="KNP36_002479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBF0874341.1"
                     /translation="MTDMSMILHFLFSGVATAGFAVFFNAPLYLLLPAGVTGGIGWIV
                     YVYLFNFTTNAVFAGFIAAALVSACSETLARKLKQPAIVFVIPGILPLIPGIGLYNTM
                     LSLIQKNYSLAMSKGTDALFLSAAIALGVLVVTSFVRTLNLLKIRKNFIPYRKSK"
     gene            complement(12436..13224)
                     /locus_tag="KNP36_002480"
     CDS             complement(12436..13224)
                     /locus_tag="KNP36_002480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HBF0874342.1"
                     /translation="MNQNEELEYKKNILKLALFVGELMIKNGAETSRVEDSVLRICRS
                     RGFYHVNIFTTPTVIIISDEKFDGFSFMKTIQSRGINLNKISLLNSFSREFVSDKEYD
                     IDNAIARLYEIQDVKPYPLWLFYSCTGIASACFACLLGGNYVLNFILTFIIAIFAAIT
                     YDKTMKISAISAFSCLVSSFLIALSGVLLVEIGILDDPKMLIVGAIMPLLPGVAFIKA
                     IRDLISGNLISGISRAFDAAMIIIAIASGVGFVLDTWYRIGGPF"
     gene            13552..14796
                     /locus_tag="KNP36_002481"
     CDS             13552..14796
                     /locus_tag="KNP36_002481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HBF0874343.1"
                     /translation="MFENLKKADPEIYESMKRELKRQQRNIELIASENIVSVPVMETM
                     GSHLTNKYAEGYSGKRYYGGCEYIDEVETLAIDRIKKIFGAEHANVQPHSGANANIGV
                     YFAMLKPGDVVMGMNLSQGGHLTHGAPVNISGQYYKFYEYGIDKDSGLIDFDEVRKIA
                     HEVKPKMIVAGASAYPREIDFKKFREIADEVGALLMVDMAHIAGLVAAGLHQNPCEVA
                     DFVTTTTHKTLRGPRGGVILCKEKYAKDIDKAIFPGIQGGPLEHIIASKAVCFKEALS
                     DEFKEYQVQVAKNAKALAEELIKRDFKLISGGTDNHLILLDLTNKNITGKAAEKRLDD
                     AYITANKNTIPFDPNGALITSGIRLGTPAVTTRGMKEEDMAIIAEAIDLCLTYDEESK
                     ARTLVVGLTEKYPLYEEYNIMD"
     gene            15119..16216
                     /locus_tag="KNP36_002482"
     CDS             15119..16216
                     /locus_tag="KNP36_002482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-diphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="HBF0874344.1"
                     /translation="MKVLILTGKFGMGHYSASNSLSEDIKAKFDNSEIIIKDIFEYIM
                     PNYSDKMYKTFSILVNRGSSLYNLFYKCAENGKKDIKFTFSDYFLNKLDTLLHEVQPT
                     VVISTFPFCSQLVSRYKEKYNSNLPLITCITDISSHSEWISKNTDCYLVASKSTKEEL
                     VFKGIDESKIKVNGIPVKKEFKRIEHVNHSTKKNILIMGGGLGLLPKSEQFYKELNSL
                     EGVKTTVITGNNKKMYYKLYGRYENIEVVGYTNEVYKYMKDSDLIISKPGGITLFETI
                     YSELPILAFNPFLQQEIDNASFILNNEIGRILGKNKKYYVDEIKDLIYDDATLKEMSS
                     NMKELKKQFDNNTLENILFSLDEQGACRECM"
     gene            16207..16905
                     /locus_tag="KNP36_002483"
     CDS             16207..16905
                     /locus_tag="KNP36_002483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HBF0874345.1"
                     /translation="MYVVGLIIVVALIFLVHSIIPTYYNKLLNKEVLKNMAGENEIAL
                     TFDDGPDKRYTEKLLDVLKENDIQAMFFVVAKNAEKEPEIIKRMLRENHIVGLHSLEH
                     RNAWLYSYSYVKKDFIESTNIMKNLGVDVNYYRPPWGHTNIFSNSFVKKYNLKMTLWD
                     VMAEDWEKDSTVDIIINKLMSRTKENSIICLHDAGENSGGAVGAPERTIEALKIAIPK
                     LKASGLKFVTPERM"
     gene            16908..17972
                     /locus_tag="KNP36_002484"
     CDS             16908..17972
                     /locus_tag="KNP36_002484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBF0874346.1"
                     /translation="MISKTEKKNKCLGSVAFLVLLMGITGYFVFRGQSVESLIKSLKG
                     ASPMFILIGFAMMFIYVACEGINIYLGMKALNQKTTLLKCMGYAFIGFYFSSITPSAS
                     GGQPAQVYYMKKDDINISYSSLILLVIVVIHQVVILAYSGIMFIMEREFILNNVSGMN
                     ILLIYGVITNVALVIGVIAIIFSKKLVNNFIISITNLLGKLRIIKDVESSRKVIISQI
                     EEYVKGAQYIKQNPKLVVQILVITIVQITAMFLVPFFVYKAFHLSTYTVFEILAIQSL
                     LNIAVSSLPLPGAVGASENSFMTLFKIFFPGHLLVPAMLLSRGISFYAFVAISGLICI
                     VVHVKSSEKVKAVKKVAYVR"
     gene            18155..18859
                     /locus_tag="KNP36_002485"
     CDS             18155..18859
                     /locus_tag="KNP36_002485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874347.1"
                     /translation="MNKEIPKKILVADDNPEIREIVEILLTGEGYEVIMATNGEEAVN
                     LVDSTIDLIILDVVMPVKTGFVACNEIREKTTAPILFLTAKTQDSDKVIGFSAGGDDY
                     LSKPFSYSELISRVKSLLRRYYIYQGKEKEREPNILKTKELCVNLDTQDVTLNGEPVF
                     LTTIEYSILILMLKNRKKVFSSENLYETIWDEQYFYTANNTIMVHIRNLRKKLEKDQK
                     NPQYIKTAWGKGYYID"
     gene            18852..20174
                     /locus_tag="KNP36_002486"
     CDS             18852..20174
                     /locus_tag="KNP36_002486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874348.1"
                     /translation="MINKIKPSKLGVILLIYVVISAAVAFILNIPFYSAVESIVKDVS
                     EGKVYFKREVNQLMDNFQTYVNNNGIRADDGDDIAKWNSDNWFVSMKIYKGNKVFYDT
                     LYYPNEVPDKSEENEFYSSPMARNYEIQFSDIKANIVVVALFRFRFQNFIEAISITFM
                     ALTFIITFLLLFSRKIKYLRKIEMGIKIVESGSLKYRIPVKGNDELSSLASSINEMSH
                     TLENQLIKEREMKNKNKDIVTSISHDVRTPLTSVICYLDLIKDHKYNSPEQLEQYIKN
                     VRSKAYQIKDLTDDLFTHFVNSGEEVSKGYEKINANEFIFQLLLDSSYTLEEKGFHIT
                     IENELYNQYHIYVDVTQFRRIFDNLCSNIIKYARKDKPIVFLIKVEDSKLLIIQKNRV
                     SNFSKNVESFGIGIKNCEKIVAYHNGSINVNSDDKEFAIEISIPAKES"
     gene            20361..21734
                     /locus_tag="KNP36_002487"
     CDS             20361..21734
                     /locus_tag="KNP36_002487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874349.1"
                     /translation="MVLTGAHYIYILFMVIILITMIMKKDTIVPCILGVFFMGLFFEK
                     NIFGAITAVFNSFIISLNELGPIILIIAIMVALSKALEANNAIQYMVRPFSRVIKNSN
                     TAFFVTGFVMLVLSWFFWPTPAVALVGAVFLPVAMRAGLPAIGVAVALNLFGHGLALS
                     TDFVIQGAPSITAGAAGVAVSYVINDGMILFWVMGIVTISMAFYTLKRDINKGMFREE
                     LKGFESEEVEEFNGKSKIATILVALGFLADIIAMYIFDLKGGDASALLGGTAVFLIII
                     INVINFGKDSLENVCENIIDGFVFGIKIFGAIIPIAAFFYMGEVAPLTGVFGKVLAPG
                     SQGLLSDIGIALSQTIPLNKFAVSGIETVVGAITGLDGSGFSGISLVGSLASVFGTAI
                     NASVGALAALGQISGIWVGGGCLVPWGLISAAAICGVSPIELAKRNFVPVITGLVVTT
                     IVAMFII"
     gene            complement(22106..23044)
                     /gene="pdaA"
                     /locus_tag="KNP36_002488"
     CDS             complement(22106..23044)
                     /gene="pdaA"
                     /locus_tag="KNP36_002488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="HBF0874350.1"
                     /translation="MFRKVLHYLTLLSISIFFIVGCSNSQNNQNENQNKETQLQEDKE
                     KIDSGKDTSNVIVSDGTDKPSKATTNNDNNKLDVSSLDNTTLDWFYIPNNKHKTPEVN
                     TDIEFKFSDYDALYNGPTKDGQKTLYLTFDEGYENGYTTKILDTLKQNQVKAVFFVTA
                     PYIKENKDLVKRMVSEGHIVGNHSKTHPSMPTKTSNLKNFNDELYDVEKLYKDVTGKD
                     MVKFFRPPMGKYSEKSLAMTKNLGYKTVFWSFAYRDWDTDKQPSHEEATQKIMDNLHD
                     GSILLLHAVSKTSTEILNDFISNARKLGYEFELLEY"
BASE COUNT         8594 a         2898 c         3685 g         8140 t
ORIGIN      
        1 tggttgtttt agaaactact tctgtaacga gtacacgatt ttaattaaag aatatataac
       61 aaatttgaaa taagtctaat atatgactta atagattaaa ttaaaataat aaatttggac
      121 tatttatcta tttataactt aaattatatc aaattgataa caaactagat attatacttt
      181 tttgtagaat agaattacaa ttatataaag aaaaattcta ttaatagtga aaaaaaagta
      241 gaaaaaagta gaaattattc ttttataaag aaagggaggg ataatattgc aagagagaga
      301 agaattagtt ttaaatccag ttccaaaaga ggaaagagtt ggatggttag ctccattgtt
      361 taatatgctt ggttctaaca tagctatatc tgaactaatg gttgggggaa ctttaatttt
      421 aggaatgact ctttctaata tgattattac atcaattata gggaacttaa tattagttgc
      481 aattattatg atacaaggtt atataggtta caaagaaggg ttaaatacgt atgtattagc
      541 taagggggca tttggagaga taggaggaaa gtatcttata tctctattac ttggtataac
      601 tagttttgga tggtttggtg tacaagcagg ggttgcagga ctatcagtac aaaagatatt
      661 cccaagtgta aacctaacat tagttacagt tatacttgga ttatttatgg ttgtttttgc
      721 actgtatggt tttaaagcta tggctaaatt taattactta gttataccac cacttatgat
      781 attaatggtg tggggagttt ttaaagcttt ttctacttat ggagttgaag ctatttataa
      841 ttatactcct caaacaacta tgagtatggt tgaaggtctt aatattgtag taggtcttgt
      901 tatagttggt gcaattatat cacctgacca gttaagatat acgagacgag taaaagacat
      961 ttggattatc agttttttag gtctagggat tatttcatta ttccaacaag ttgcagctgg
     1021 tgtaatgtct atgggagcac ctacttggga tataacagaa gtattggcta atttaggttt
     1081 tggatgggta gcgtttgtta ttttaatact tgcatcttgg tctacaaacg tatcaaatgc
     1141 ttattctggt ggattagcat taaaaactat ttttccaaat gtaaaaagaa atgttttgac
     1201 tttagttgca ggtctaatag gtacaataat agcagctact ggtataatat ttaaatttca
     1261 gtcattttta tctttcttgg gaatcgcagt tcctgcaata gcaggaatta tgtggtgtga
     1321 gtattatttt atacaaggaa gaacttataa gcatagagaa ggaataaatt ggattgcagt
     1381 aataagttgg ttaataggtt ttgcagcgtc gtattatagt tcaaaaataa atttcttaat
     1441 acctccgata aatggaattg tagtgagtat ggttatttat tatatattaa tgaattgttt
     1501 tggaatcaaa gataaataaa gggggcaatt acatgggtcg taaggtgaaa ataggtataa
     1561 ttcaacaaca cagtgtactt ggaaatgtta aaaaaaatat agaaaaagca gtagagatga
     1621 tagatgactt aggaaaacaa ggggcagata taatttgttt accagaacta tttgctacag
     1681 gatataattt agagtcttta ggtggagtta aaacattaga attaataaga gaacataata
     1741 agtacataga ggaatcaatg tcagaagctg ctaaaagaaa taatgtatac ctgatatctc
     1801 catatggaac cttagaaaaa gggtctacac atgtttataa ttcagcagtt atatttgata
     1861 gaaaaggtaa gattatggga gaatactgta aaaatcatct gtggtcatta gaagcagtat
     1921 actttaaagg aggggaaaaa gtagaggtat atgatgctga ttttggtaga tttggtgtaa
     1981 tgatatgtta tgatgcaggt tttccagaag tatccagaga attgacatta aaaggttctg
     2041 aaataatatt tataccatct gcatggagaa tacaagatga agatatgtgg gatttaaatg
     2101 tatctcaaag agctttagag aacactgtat atacagtagg tgtaaattta gtaagtaatg
     2161 actctaattt aatactattt ggaaagagta aaatatgcaa tcctagaggt actgtaataa
     2221 ctcaattaga tacatacagg gaaaaatatg tattatcaga gattgattta gatgaaataa
     2281 aaaagtatag ggaagatatc ccctatttga aagacagaaa aagtagctat aacatataat
     2341 tctatactat aatacaagtt caatataaaa tgataaaaag aggatgtatc aatattaaga
     2401 ttaaatttat tatactttga tatatcctct ttaatattat caactttgat ttaaatattt
     2461 ttaaaatagt tgataagaaa gtttttgaac aacaacacag ctttagattc atagttttcg
     2521 ctaaaccatg aaagatttaa atatctttta aattcaatat ctttgatatg taacaactta
     2581 atctcagggt cttgagataa tccccatgat tttccacata taaatccaac tccttgaagt
     2641 gattttataa gagcataaat tgtatatggt gaatcagact caaatgctat tttgggtttg
     2701 aaattagctg attcgcacag gatatcaatt acctctctat aattctcacc cttcgttata
     2761 actataaagt tttcatctga aacttcgctt agatatactt catcctttaa tgataaagga
     2821 tggtttattg aaactcctaa tagtatttct tcgcatgtta aagttatgct attttctgag
     2881 tttagctttg taaatgaaga agatatgtac aaatcaaaat cacttttttt ataagatgat
     2941 ggcaaagtat gtgacacatt aaaagtaata ttgggatata gttttctgaa attactcaaa
     3001 agtgatggta acacattagc cgctgcagga gataatatct ttacttctcc tgaattttcc
     3061 aaagaagtgt cttgtaactc cttttttgaa ctttctacta aatctaaaat gctatctact
     3121 ctttttagaa acaatcttcc atactcattt aaaacaatat atcttccttt tctgtcaaat
     3181 aactgaactc caagttcttt ttctaaggaa gatatagttt tgcttaaagc tggctgtgct
     3241 atatttaact tgtgtgatgc ttttgttatg tgctccattc tagcaacagt ttgaaaatac
     3301 ttaagatgca ataaatccat agtataaaat acacctcttt taatatgact tgagttatat
     3361 caattttata atcaactcca cattatacat tataatataa agtttatata ataaactaca
     3421 atatattaaa aagttattta aattgttatt tatattttgt acataatcta attaaaaaaa
     3481 gtaactttaa atggttaact aaggaaatat tgttacaaac tttagttata taaaaaattc
     3541 gtttgatgag caaagtatta atgtcaagta agaataaaag cttattagat aagaaaaata
     3601 atattttata ataatgatgt tacttaaatt attatgttat actattttaa ataggaaaca
     3661 tttagatact ataattttag ggggagtcaa gatgaaatta actaaatcaa tatcatcaat
     3721 gctgtgctta tctctagttt taagcttatc accagtagca tatgcaaatg aaataagtag
     3781 aacaacagtt gagaatactt tagtaggtca ggatagatat caaactgctg ttgaagtaag
     3841 taaaaaagga tggagtagtg caaatgaggc tgtagttgta aatagtgaat ctattgtaga
     3901 tgcattagct gtaacaccat ttgctaaatt aaaaaatgct cctatattat tgacagaaaa
     3961 aaataatcta aattcacaaa ctgagaaaga attaaaaaga ttaggagtta aaaaagttta
     4021 tataattggt ctatctagtt ctgtatcaaa tgatgtgcaa aaacagttag aatctaataa
     4081 tttaactact gatagagttg gtggtagtga tagataccaa acagctttga gtatagctaa
     4141 aaaaatagaa ggattaaaag atatatcaga aatagctgta gtaaatgggt acacaggtct
     4201 tgcagatgca gttagtatag cttctgtagc tgctactaat ggaatggtta tacttccagt
     4261 atctgatgca tctggtatat ctagctttaa agattttata gaatctaaga atataaataa
     4321 atcatacata ataggctcta ctaatgctgt atcagataaa ataaaacaaa gtttacctaa
     4381 ttcagaaaga ataggtggag cagatagaaa tgaaactaat ggtaaagtaa tagaaaagtt
     4441 ttatacatct aataaattaa acaatgtatt tgtggctaag gatggaatga aaaatcaaaa
     4501 tcaacttata gacgctttag cagtaggagt actagcatca aaagaaaatt ctcctgtact
     4561 aatcgtagga gaacaattaa gtgcaacaca aaagagtgta ttttcgaata aaaatgctac
     4621 ctctataact caagttggta gtggaggaaa tgaaaatgca tttaaagaat taaaagattt
     4681 acaggcaaat agtaacaata agagagtaat gtatgtaact aatacagata aggtaaatat
     4741 aagaaatgat gctacaatag aagcttctgt tataggatat ctaaataatg gtgatgaagt
     4801 agaagtttta gatgtgttaa aaactggatg ggtagaaata aaatacaatg aaggtattgg
     4861 atatgttagt gggtcttatt tgacaaataa taagcctgat aatagtaatg aaaatataaa
     4921 aataaagtat gtaaaagaaa aagatggtct aaatgttagg aaaggaccaa gtacagaaga
     4981 tgaaaaaata ggtcaccttt catatggaag caaagtagaa acaatagaaa tgtttgctac
     5041 tggatgggta aaaataaagt ataatggtgg atatggttat gtaagtaatg attacttatc
     5101 tgatacacca gttatttaat tataagtaac aataaaaaaa ctgctttaat ttgtaaagca
     5161 gtttttttat aaaaatttaa gtctaataac tatttctatt ttgatacctt aatcctggga
     5221 tttattatta tggatattat caacatacaa acactccaaa tccagtgtct aattccaaac
     5281 ttagatatta ataaattcag tcctgctatg gtaaataagc agtatttaat tacaattaaa
     5341 agtgtattta tagaaagccc cttcatagaa agtatcctaa atccaataat agacattcta
     5401 agtcctataa atgccaataa tatacctgca atatcctgaa ttaagtaata gtattcaaat
     5461 ttcatattca atcaactctt ctctgagcag tatcaaatat ttctaactct tcaatttcat
     5521 catctgtgta tgtaagcata gtaaaaccag ttacaccata aataaatgaa attataggtg
     5581 taatccaact taagaaacaa tatggaataa attctagtgg gcttacacca agagtctgag
     5641 cacagaaaac agcatttgaa ttccatggta ttaatggacc accaagtgta gctgtatctt
     5701 ctataattct agatagattt tgtggtttta atttaaattc tttgtatatt ggagacatta
     5761 gagttccgac aaatacagaa gtgaacatca ttgatgaact aaatgcattt gcaaagtaac
     5821 ttactataaa agtagaccca accaatttag ttcttgattt tcctatttta gttataagag
     5881 gttgaagcag tacttctaag aatccagttt tttggagaat accagcaata acgaaaacta
     5941 caaatactag taaaacggtt tcagccatac tcattattcc accacgattt aatagtttgt
     6001 cggcatagac aaatccagta tctatagtaa atcctgatag catgtaattt aaaacatcac
     6061 ctattttttc tccttcttga aatactgcta taataagtcc catgatagct gaacttagta
     6121 tagatataat gggtggcttt tgtagcaata aaagtaataa taaaaatatt attggaatca
     6181 ttgctactaa accaatatga aagtttgaat ttaatacatc cttgatttga tttatttgaa
     6241 catagtctat agtattattt gaatacttaa atccaattac tgtatacaga actatacata
     6301 ttacgtatgc aggtcctgtg gtataaaaca tatgcttcat atgtgtaatt acatctgtct
     6361 tacaaactgc tgcagctaag tttgtagaat ctgatagagg tgacatctta tctccaaaga
     6421 aagcaccaga aatgactgca ccagctgtta aaccaagagg aatacccata ctagtaccaa
     6481 tactcatcat tgctatacca gaagttccaa gagtccccca agatgtacca gtagcaacag
     6541 aagttaatga acatacgatt aatgttgtaa gcagaaaata tttaggggtt attattgtta
     6601 gtccactata tactactgtt ggtattgtac cagcagctat ccaagctgct attagtacac
     6661 caacagaaag tataattaag tttgattgaa aggcatcttt accaacttca aatccaaaag
     6721 cttctatttc atcattagta taaccaagtt tcatagctgc aggaactact ataagccatg
     6781 aaagtaaaaa cattgtagtt atagaagcat taaatacaac tataccaact gatgttagag
     6841 ctattattgc aagcattact aacaaggaat atctaaatga aggtattttt ctttctgtat
     6901 tcattttcat agtgcaaatt ctccttaaat atttttagtt aattgcattt tttattctta
     6961 taagagcttc ttcaagcata cttcttggac aagctaagtt tattctttga tacccacttc
     7021 ctccaatgcc aaagctgttt ccttgattta gagcaacttt acctttttgt acaagtatac
     7081 tttctagttc ctcatcactt aatccaagtg cactaaagtc tacccataat aaataagtac
     7141 cttctggttt tctaacttta agttttggca tattttcatt tatatatttt atagcaaaat
     7201 ctatattaga ttctaaatat tctaaaaatg attctagcca agattcacca ttattatatg
     7261 aagcttcagt tgcaactaag ctaaagcaat tatttctctt tatatcaatt ctggtaaagg
     7321 catcatctaa caatttatag tctttttcat caggtagtat tacatatgat gattgaagac
     7381 cagctatatt aaaagtttta gttggagcca tacaagtaat tgtatttttt tcaaattctt
     7441 tagaaataga tgccatagga atatgcttat gtttttttaa tataatgtca ctatgtattt
     7501 catcagatat gatttttaca ttatgcttaa gacaaatatc tcctagtttt tttaattcat
     7561 cttttgtcca tactctacca actggattat gaggattaca aagtatgaat aattttacat
     7621 ctttaatctt gttttcaatg tcttcataat ccattatgta gtttccattt tctagttttt
     7681 gtaatgggct tataattagt tctctattgt tattttttac aacactatta aaagggctgt
     7741 aaactggttc ttgtatcatt attttatcat ttgcttttgt gagttcattt attaaaagac
     7801 ttatagctgg gataacacct ggactataaa ttaaccactc actttttatt ttccagttat
     7861 gtctcctatc tagccagttt actatagatt cattgtaaga atctggtctt gttgtgtagc
     7921 cataaatctc ttgttctagt ctatttttta aggaatcaat tatacaaggt gcagccttaa
     7981 aatccatgtc agccacccac ataggaagta aatcattagt tccatacttt ttttccattt
     8041 ctgaccattt agatgaaaaa ttattgcttc tatcaacaat ctcattaaaa ttataattca
     8101 ttgtaaatac ctccagtaat tttaatttta tgttaataat attaagcaaa caacgtgcca
     8161 atattgataa taaaaaatat ttattcacaa gttaatattt aatattaagt aatttcagag
     8221 catagataag ataaaaatat taattatact taaaactttg tggaaaaggt tatttctaat
     8281 aaatttttaa atatatgaaa atgtaattaa ataggttaaa taggtttaac tgtttaactt
     8341 gttagaccta tttatatttt ttagaaattc tactcctttt gatgttataa ttgaacctcc
     8401 acgaccaaca agtatgtcta caagcccaaa gttttgtagt tctaaaagca tatttctaat
     8461 ctgttgttct gtcaaaaatc tattttcctc taaagctatt ttacataagc tttttctacc
     8521 tattctttct tttaaatcat aagccttttt taaattatcc aatataaata tgtattcatc
     8581 tagtgacctt ttaaaattat agtcgtattt catgatgttt ttgtctttgc caatgttgaa
     8641 ttgatacttt tttatattat cacttacttt attacaaacg gttctactat aatttgaatc
     8701 tatagtatct aatatatatt caggtaaatc acatatttct ataatatctt tttccaagta
     8761 acagaagtat tctcctaagt ttcttaattc tcttacattt ccttcccatc tatacatttt
     8821 aaagatttct tttacttcct cacttagaat aaaattacat ggaatatcat attttaatga
     8881 accaaaaatt tcaaatatat cagcaggtct ttccctaagt ggatgtattt taaggggaag
     8941 aacattcaac ctaaaatata aatctcttct aaacatattt ttagatacaa gttcttttaa
     9001 atttctatta gtagctgcaa ttattcttac atcaatgtca atgacattat tagaaccaat
     9061 acgtcgtact tgtttttctt gtatgactct aagtaattta gattgagaat ttaaatccat
     9121 ttctccaatt tcgtctaaaa atatagttcc attgttggct aattcaaata aaccaatttt
     9181 cccacctttt ttagcaccag taaaagcccc ttcatcatag ccaaataatt cactttgcag
     9241 tagattttct tgaaaagtac tacaatttac tgcgacaaaa ggaccatctt ttctcctaga
     9301 agcactatga atggattgag caaataattc tttaccagta ccactttcac caattataag
     9361 gatagatgaa tttgattgag ccattttatt agcaattttt tttgtattaa tagtttgtat
     9421 actagaacct aatatgtcat caaatgtgta tttactgata ttaccagagt ttactagttg
     9481 tgctcttaat ttagcttgct ttttttctaa ttgagaaaac tttgtcatct ttagtataaa
     9541 tccatcaaat acatttaatt gtatatgttt aatctctaaa tttatatcaa tatgatttat
     9601 tttaatcaat ttctcaaaaa atggagtttt attggtcaat atgctttgaa aattgatgtc
     9661 ttttatgcaa tcaccaacaa atgagtcaat catttcattt gcatttatag acaaaatttt
     9721 tctagccata tgattataga attgaattat tccatcgtta tttgtgcata taattccatc
     9781 atcaattata gatagcaaca aatcaaattg tctttcaaac ttatttgcat ctaacaataa
     9841 ctcacctgta ctataacttg taggaattat tttttctacg tattttttta ttaggtcatc
     9901 ttttattaga tgttttaatt tggtttttgt agcaatttca acaatacaac ttaaatctat
     9961 tattctgtat tttaaatcta taacttcaca atttttaaac ttaggcaaga ttttttcgcc
    10021 aggagttagg attacagcat ctgtgggagt aaactcaatc tctggatagc agggcaggat
    10081 atttatattg tctattccta atctatgtat taaagaaatt gtttctattg ccatatcttt
    10141 acttaagtta tatacataaa taattttatc tttttctaat ttggatatca tatcaatact
    10201 gttcttttca aatgtcaact taggaacaat gatttgagca tcatagtgag ataattttac
    10261 tatttcatca tattttaaat aagcagatag gagtataagt ttttctttaa aaaactttaa
    10321 atttccctct tcaaatgagt ataaatttat ctttagatta tcacctaaga attgccttat
    10381 ttgattttca taaatttctc cagcgtcttt ttttaaactt acaatagcta attccatttg
    10441 tttcatttta acctctcata caaatttgac ttattttaga ttacataata attaaattag
    10501 attaaataat attatttaat tattattata aatttattat agactacaca ttgaagtaaa
    10561 agaagtagct aaaattattc cttttatttt tgttttttgt atctatttgg tataatagta
    10621 ttagagcgta taataattta ggcaaaattt tttaaggaag actagaggag aatataaaat
    10681 gaaaaaatgt ctttactgta atagggatat aaagtcacca aataataaat tagctataaa
    10741 atatgatgac aatatgaata tatatccatg tcgtgcagaa tgtaaggaaa aaattgaaga
    10801 atatatagca aaaaaaccta catataagtt tataaatata ttagaggttc ttttaggtgt
    10861 gggcggaata ttctgctttt tgagtaaatg gactattgca gcccaagttg tacttggaat
    10921 tgatgcactg gttatatttt tattcccatt ggcaggattt aaaatgaatg gaaagttaag
    10981 tatggaacaa actaagaatc aaagtaggtc tattgcaata tcaattttgg catttatagt
    11041 aataataact gtattatatt ttaaacaagt tggtaagtag agcataattg tataagacat
    11101 cattagagta tgaggtgagt ttatggaaga aagaaaatta gcaccaaaca atgagaggga
    11161 agctctcata aaaagattaa aaagaataga aggtcaagtt aagggtatac aaaagatggt
    11221 ggaacaagaa cgttattgtg ttgatatatt ggttcaaata tctgctataa ggtctgctat
    11281 aaatagagta ggcacaatta tcttagagaa tcatataaaa ggatgtgtag cagaaagtat
    11341 taaacatgat gatgctgata aaactgaaga gatgataaaa gagcttatgg atactataaa
    11401 taaatttaca aaataaggag gcggttagtt atgaatcaac aaggatttat tatggaaatt
    11461 gttgatgata gaactgcaaa gttaaaaatg caaagacatt cagcttgtgc tgcttgtgga
    11521 aaatgtgcta ctacaaattc agcagagtca aaagaaatat tagtagaagt agacaacaca
    11581 attggtgcaa aagttggtga ccatgtagaa gtgagtatgg ataatatgaa tgtattaaaa
    11641 gcagctgtaa tggcttatat aatacctctt atagcacttc ttgtaggaac aatagggact
    11701 tattatatat tgggggcaat tggaatgaca actggagttg aagccataag tggattagtt
    11761 ggaatttgtc ttacaataat ctgttattta tacttaaaga agaatgacaa aaaatttaga
    11821 gacagtagag aatttatacc agtaataaca agaatattaa ttgaccttta agataattat
    11881 aattaaaaaa tagcaatgta ctttttaaat aaatactcaa tacgtatttg tagagtttaa
    11941 gtacattgct atttttatat ttttattttg attttctgta aggaataaag ttttttctga
    12001 tttttaaaag attcaatgtt cttacaaaag aagttacaac taatacacca agtgctattg
    12061 cagcacttag aaatagcgca tctgtacctt ttgacatagc caaagaataa tttttctgaa
    12121 tcaaagacaa cattgtatta tatagcccaa ttcctggtat tagaggaaga atacctggaa
    12181 ttacgaacac aatagctggt tgctttagtt ttcttgctaa agtctcactg cacgctgaga
    12241 ccaaagcagc agcgataaaa cctgcaaaaa ctgcatttgt agtaaaatta aataaataaa
    12301 catatacaat ccaaccaatt ccgccagtta ctccagctgg aagaagtaga tatagtggag
    12361 cattaaagaa aacagcaaat ccagcagttg caacacctga aaataaaaaa tgcaaaatca
    12421 tagacatatc agtcattaga aaggacctcc tattctatac catgtatcaa ggacaaaacc
    12481 aactccagaa gcaattgcaa taataatcat agcagcatca aaagcacgag aaattcctga
    12541 tattaaattc cctgatatta aatctctaat agcttttata aaagcaactc ctgggagtag
    12601 tggcattata gcgccgacta taagcatttt agggtcatct aaaatgccta tttcaactag
    12661 tagaactcct gaaagtgcaa ttaaaaaaga agatactaaa caggaaaatg cagatattgc
    12721 acttatcttc atcgttttat cataagtaat tgcagcaaag attgctatta taaacgtaag
    12781 tataaaattt aatacataat tccctccaag caaacaagca aaacaagcag atgcaattcc
    12841 tgtacaagag taaaataacc ataaaggata aggttttaca tcttggattt cataaagacg
    12901 tgcaatggca ttatcaatat catactcttt gtcactaaca aattctcgag aaaaactgtt
    12961 taataaagaa atcttattta agtttatacc tcttgattga atcgttttca taaacgaaaa
    13021 gccatcaaat ttctcatctg aaataattat tactgtagga gttgtaaaaa tatttacatg
    13081 ataaaaccct cttgacctgc atattctaag gacactgtct tcaaccctag atgtttcagc
    13141 tccatttttt atcatcagtt cccctacaaa tagagctagt tttagaatat ttttcttata
    13201 ttcaagttcc tcattttgat tcataaatac acctccaaat taaaaaacgt aatattgaaa
    13261 ttatatcaaa tttttaagta atattcctta atatctatac aaatatatta tctttttttt
    13321 gtttcaaaat agtcacattt aaattatatc caattaaaag aattagacaa tattatttat
    13381 tatattttaa cttaaaaata aagaaagtaa ctatgttaaa tatggaaaaa tggcaaaaca
    13441 cttgactatt aattggtaaa ggactataat aataaattat catattgata aaaacgaaaa
    13501 ttatgaaatg tctgtaaaaa taaaatttaa ataataacta ggaggagtaa tatgtttgag
    13561 aacttgaaaa aagcggaccc tgagatttat gaaagtatga aaagagagtt aaaaagacaa
    13621 caaagaaata ttgaattaat agcatcagaa aacatagtat cagttccagt aatggaaact
    13681 atgggaagtc atcttacaaa taagtatgca gaaggttact caggcaaaag atattatggt
    13741 ggatgtgaat acatagatga agttgaaact cttgcaatag atagaatcaa aaaaatattt
    13801 ggagcagaac atgctaatgt tcaacctcac tctggagcaa atgcaaatat tggtgtatat
    13861 tttgctatgt taaaaccagg tgatgttgtt atgggaatga atttatctca aggtggacat
    13921 ttaactcatg gtgctccagt taatatttct ggtcaatatt ataaatttta tgaatatggt
    13981 atagataaag acagtggact tatagatttt gatgaagtta gaaagatagc acatgaagta
    14041 aaacctaaaa tgatagttgc aggagcaagt gcatatccta gagaaataga ttttaaaaag
    14101 tttagagaga tagctgatga ggttggagca ttgcttatgg tagatatggc tcatatagca
    14161 ggtcttgtgg ctgctggtct tcaccaaaat ccatgtgaag tggctgattt tgttacaaca
    14221 acaactcaca aaactttaag aggacctcga gggggtgtta ttctttgtaa agaaaaatat
    14281 gctaaagaca tagacaaagc aatattccct ggtattcaag gtggacctct tgaacatata
    14341 attgcttcta aggcagtttg ctttaaagaa gctttaagtg atgagtttaa agaatatcag
    14401 gtacaagttg ctaaaaatgc aaaagcctta gctgaagaac ttattaaaag agattttaaa
    14461 ttgatttctg gaggtacaga taatcattta atactattag atttgactaa taaaaatata
    14521 actggtaaag cagcagaaaa gagattggat gatgcttata taacagctaa taaaaataca
    14581 attccatttg acccaaatgg tgctcttatt acaagtggaa taagacttgg tactccagct
    14641 gtaactacta gaggtatgaa agaagaagat atggcaataa tcgctgaggc tatagaccta
    14701 tgtttaactt atgatgaaga atctaaggct agaacattgg ttgttggttt aactgaaaaa
    14761 tatcctttat atgaagaata taatattatg gattaattat aaagaacaac taaataaaat
    14821 acatttaaat aattacaatg attgtgtatg tatttgaata tagttagata taaaaaaggt
    14881 gtctcaaaat gaacttttta gtttatgagg cacttttttg tatggaatcg aacatatttg
    14941 tgttatttaa ataataaaaa atatggttat ctctattttt agatggtctc tttgtatttt
    15001 ttaattaaaa ctttaagatt tcttaagaat tatactaggt ttttctaaag atttaaagtc
    15061 tatacttata agtatagtaa tcatatgaaa agaaaagctt taacgaggag ggaatcttat
    15121 gaaggtatta attcttacag gaaaatttgg tatgggtcat tactcagcat caaattcttt
    15181 aagtgaagat ataaaagcaa aatttgataa ttcagaaata ataattaaag atatatttga
    15241 gtacattatg cctaactatt cagataaaat gtacaagact ttttctattc ttgtaaatcg
    15301 gggaagtagt ctttataatt tattttataa atgtgctgaa aatggaaaga aagatataaa
    15361 atttactttt tcagattatt ttttaaataa attagataca ttacttcatg aagtacaacc
    15421 aacagtagtt atttcaactt ttccattttg ttctcaatta gtatcaagat ataaggaaaa
    15481 atataactca aatcttcctt taataacatg tataactgat ataagtagtc actcagaatg
    15541 gattagtaaa aatacagact gttatttagt agctagtaaa tctactaagg aagaacttgt
    15601 ttttaaagga atagatgaat ctaagattaa agttaatggt attccagtaa aaaaagaatt
    15661 taaaagaata gaacatgtaa atcattcaac taaaaaaaat attcttataa tgggtggagg
    15721 attaggatta ctgcctaaat cagaacaatt ttacaaagaa ttaaatagtt tagaaggagt
    15781 aaaaactact gtaataactg gtaataataa aaaaatgtac tataaactat atggtagata
    15841 tgaaaatata gaggtagtag gttacaccaa tgaagtatat aaatatatga aagattctga
    15901 ccttattatt tctaaaccag gtggaataac actatttgaa acaatttatt cagaacttcc
    15961 aatattggca tttaatccat ttttacaaca agagatagat aatgctagtt ttatattaaa
    16021 taatgaaatt gggagaatac ttggtaaaaa taaaaaatac tatgtagatg agataaaaga
    16081 tttaatttat gatgatgcta ctcttaaaga aatgagcagt aacatgaaag aattaaaaaa
    16141 acaatttgat aataatacct tagagaatat tttattttca cttgatgaac aaggagcgtg
    16201 tagagaatgt atgtagtagg tttaattatc gttgttgcat tgattttttt agtccattca
    16261 attataccta catactataa taaactatta aataaagagg tattaaaaaa tatggctgga
    16321 gaaaatgaaa ttgcacttac atttgatgat ggtccagata agagatatac agaaaaatta
    16381 ctagatgtgt taaaagaaaa tgatatacaa gctatgtttt ttgtagtagc aaagaatgct
    16441 gaaaaagagc ctgaaattat aaaaagaatg ttgagagaaa atcatatagt tggtttacat
    16501 tcattggaac acagaaatgc atggctttat agttatagtt atgttaaaaa agattttatt
    16561 gaaagtacaa atataatgaa aaatttaggt gtagatgtaa actactatcg tccaccatgg
    16621 ggtcatacta atatattttc aaattcattt gttaaaaaat ataatctaaa aatgactttg
    16681 tgggatgtaa tggcagaaga ttgggagaaa gatagtacag tagacattat tataaacaag
    16741 ttaatgagta gaacaaaaga aaattctata atttgtttac atgatgcagg tgaaaattca
    16801 ggtggtgcag taggtgcacc tgagcgtact attgaagctt taaagatagc tattccaaaa
    16861 cttaaagcca gtggtttaaa gttcgtaaca ccagaaagga tgtagttatg ataagtaaaa
    16921 ctgaaaagaa aaataaatgc ctaggtagtg tagctttttt agttttacta atgggcataa
    16981 caggatattt tgtttttaga gggcagtcag ttgaatcatt gataaaatca ttaaaaggtg
    17041 caagccctat gtttatacta attggatttg caatgatgtt tatatatgtt gcctgtgaag
    17101 gtataaatat atacttaggt atgaaagctt taaaccaaaa gactactctt ttaaaatgta
    17161 tgggatatgc ttttattgga ttttatttta gttctattac accttcagca tcaggtggtc
    17221 aaccagcaca agtttattat atgaaaaaag acgatataaa tatatcatat tcttcactta
    17281 tactattagt cattgttgtt attcaccaag tagttatact ggcatatagt ggaataatgt
    17341 tcattatgga acgtgagttt atattaaata atgtaagtgg tatgaacatt ttactaatat
    17401 atggtgtaat aacaaatgtt gctcttgtca ttggagtaat tgcaattata ttttcaaaaa
    17461 aacttgtaaa caattttata atatcaataa caaatttatt aggtaagtta agaataataa
    17521 aagatgttga aagttcaaga aaagttataa tatctcaaat tgaagagtat gttaaaggtg
    17581 ctcaatatat aaagcagaat ccaaaacttg tagtccaaat tttagtcata actattgtac
    17641 aaataacagc tatgttttta gttcctttct ttgtatacaa agcttttcat ctatcaacat
    17701 atactgtatt tgagatatta gcgatacaat ccttgcttaa tattgctgtt tcttcattac
    17761 cattgccagg ggctgttgga gcttctgaaa atagttttat gacattattt aagatatttt
    17821 tccctggtca cttattagtt ccggcaatgt tacttagtag gggaataagt ttttatgcat
    17881 ttgtagctat aagtggattg atatgtatag tagtacatgt aaaatcttct gaaaaagtaa
    17941 aagcagtgaa aaaagttgct tatgtaagat aatattatat agattatttt tattaatatg
    18001 tcaatttgtg tgtatatttt aattaagctt taaacatatt tacaggagta gaaactatta
    18061 aaacgtgtga cattgctaag cttttgctaa taaagtataa tattttatat agtttgaaat
    18121 atttaagaaa tatagcaaaa aaaggagctt ggtgatgaat aaagagattc caaaaaaaat
    18181 tttagtagct gatgataatc ctgagattag ggaaatcgta gaaatacttt taactggtga
    18241 aggttatgaa gttattatgg caacgaatgg agaagaagct gtaaacttag tagatagtac
    18301 gattgatttg attattttgg atgttgtaat gcctgtaaaa acaggatttg ttgcatgtaa
    18361 tgaaattaga gaaaaaacga cagcaccaat attattttta actgcaaaaa ctcaagactc
    18421 tgataaagtt attggatttt cagcaggagg agatgactat ttatcaaagc ctttttcata
    18481 ttctgaacta atttcaagag ttaagtctct acttagacgt tattatatat accagggaaa
    18541 ggaaaaggaa agagagccaa atatattaaa aacaaaagag ttatgtgtca atttagatac
    18601 tcaagatgtt acactaaatg gagaacctgt gtttttgaca actatagaat atagtatatt
    18661 aattcttatg ttgaaaaata gaaaaaaagt tttttcgtct gaaaatttat atgaaactat
    18721 ttgggatgag cagtattttt atacagcaaa taatacaata atggttcata ttagaaattt
    18781 aagaaaaaag ttagaaaaag accaaaaaaa tccacaatat ataaaaaccg catggggaaa
    18841 ggggtattat attgattaac aaaattaagc catctaagtt gggagttata ctattgatat
    18901 atgtagtaat ctcagctgca gtggctttca ttttaaatat accattttac tctgctgttg
    18961 aatctatagt aaaagatgta tcagaaggga aagtatattt taaaagagaa gtaaatcaac
    19021 ttatggataa ttttcaaact tatgtgaata acaatggtat aagagcagat gatggagatg
    19081 atatagcaaa atggaatagt gataattggt ttgtttctat gaagatatat aaaggaaata
    19141 aggtttttta tgatacatta tactatccta atgaagtacc tgataagagt gaggaaaatg
    19201 agttttatag cagtcccatg gctagaaact atgagataca attttctgat attaaagcta
    19261 atatagttgt agtagcttta tttagattta gatttcaaaa ttttatagaa gcaatttcta
    19321 ttacatttat ggcacttaca tttattataa catttttact gttgtttagt agaaagataa
    19381 agtacctaag gaaaatagaa atgggtataa agatagtaga gagtggcagt ttaaagtata
    19441 gaataccagt aaaaggtaat gatgaattat catcacttgc atctagtatt aatgagatga
    19501 gtcatacatt ggagaatcaa cttataaaag aaagggagat gaagaataaa aataaagata
    19561 tagtaacttc aatatcacat gatgttagaa ctccattaac gtcagtaatt tgttatttag
    19621 atttgattaa agaccataaa tacaatagtc ctgagcaatt ggaacaatac ataaaaaatg
    19681 taaggtctaa agcatatcaa ataaaagatt taacagatga cctttttacg cattttgtta
    19741 attctggaga ggaagtttca aaagggtatg aaaaaataaa tgctaatgaa tttatttttc
    19801 aattactttt agatagttca tatacattgg aggagaaagg atttcatata acaatagaaa
    19861 atgaacttta taaccaatat catatttatg tagatgttac acaatttaga aggatatttg
    19921 ataatttatg ttctaatata ataaaatatg ctaggaaaga taagcctata gtatttttaa
    19981 ttaaagtaga ggattctaaa ttactaatta tacaaaaaaa tagagtaagt aatttttcta
    20041 agaatgtaga aagttttgga attggtataa agaattgtga gaaaatagtt gcatatcata
    20101 atggaagcat aaatgtaaat tcagatgata aagaatttgc tattgaaata tctattccag
    20161 caaaagaatc ataaaaattt aaattatata ttgtgtaatt gctattatat attgtgtaat
    20221 tgcttatgta aaattctatg aagcaggaag catgtgactt tagttatggg atgttcaata
    20281 ttgtgtacct ctaggcaagt aacaagttta cttacaagac catataatat tattatctta
    20341 aaaaaagggg acataataat atggttttga caggagcaca ttatatttac attctattta
    20401 tggtaattat attaattact atgattatga aaaaggatac aatagtacca tgtatattag
    20461 gtgttttttt tatggggttg ttctttgaaa aaaacatttt tggtgctata acagcagtgt
    20521 ttaactcttt tattatatct ttaaatgagt tgggtccaat tatcttgatt atagctatta
    20581 tggttgcatt atctaaagcc ctagaagcca ataatgctat acagtatatg gtgagaccat
    20641 tttcgagagt tataaaaaat tctaatacag cattttttgt aactggattt gttatgttag
    20701 ttctttcttg gtttttctgg ccaactccag ctgttgcctt agttggagct gtatttttac
    20761 ctgttgctat gagagctggg ctaccagcaa ttggtgttgc agtagcatta aatttatttg
    20821 gtcatggtct tgccttgtct acagactttg ttattcaagg agctccaagt ataacagctg
    20881 gtgcagcagg tgttgcagta tcatatgtta taaatgatgg tatgattttg ttttgggtga
    20941 tgggaatcgt aaccatatct atggcatttt atacattaaa aagagatatt aacaaaggaa
    21001 tgtttagaga agaactaaaa ggttttgaaa gtgaagaagt agaagagttc aatggaaaat
    21061 ctaaaatagc aactatttta gtagctctgg gatttcttgc tgatataatt gctatgtata
    21121 tatttgacct aaaaggagga gatgcatcag ctcttttggg tggaacagca gtatttttaa
    21181 taataattat aaatgttata aattttggca aagatagtct tgaaaatgta tgtgagaata
    21241 taattgatgg ttttgtgttt gggataaaaa tatttggagc aattatacca atagcagcat
    21301 ttttctatat gggtgaagtt gcaccattga caggtgtatt tggaaaagta ttagcaccag
    21361 gttcacaagg tttattatca gatataggca tagctctttc tcaaacaata ccacttaata
    21421 aatttgccgt atcaggtata gaaactgtag tgggagcaat aactgggctt gatggttctg
    21481 gattttctgg gatttcatta gttggttcac ttgcctctgt atttggaact gctataaatg
    21541 caagtgttgg tgcactagct gcattaggac aaatcagtgg tatatgggta ggtggaggct
    21601 gtctagttcc ttggggtctt atttcagcag cggcaatttg tggagttagt ccaatagaat
    21661 tggcaaagcg aaactttgtc ccagttataa ccggattggt tgtaacaacc atagtagcaa
    21721 tgtttattat ttaataaatc gaataaatct ttaattgtat aaattaaaaa tagatgtgta
    21781 gctataattt attataattg ttttactaat tctaagccat acatctattt ttattgatat
    21841 ttttattagt attctttaat aaaataatat ttttcattat actatacata acatctaaat
    21901 ataacatcta aaatactgtt atctatattt aatatcttgc caaatttttt gatgttttat
    21961 tgccctgtcc caccaacata tataagctat cacaagtttt tacctatact atcaccaaac
    22021 aaaaattcta attttaattt attattttat aacctatatt atattaacta tattagtttg
    22081 tagactttag atgtaattat aaatattaat actccaagag ttcaaattca tatcctagtt
    22141 ttcttgcatt tgatataaaa tcatttaaaa tttctgtact agttttggaa actgcatgta
    22201 gtaacaagat agaaccatca tgtagattat ccattatttt ttgcgttgct tcttcatgtg
    22261 atggttgttt atcagtatcc cagtctctgt atgcaaaact ccaaaataca gtcttgtatc
    22321 ctaaattttt agtcattgcc aagctttttt ctgagtattt tcccatagga ggtctaaaaa
    22381 atttaaccat atctttccca gttacatctt tatataactt ttcaacatca tataattcgt
    22441 cattaaagtt ttttagattg cttgtttttg ttggcataga tggatgggtt ttactatgat
    22501 ttccaactat atgtccctca gaaaccattc tttttactaa atctttattt tcttttatat
    22561 atggagctgt aacaaaaaaa actgctttaa cctgattttg ttttagagtg tcgagtattt
    22621 ttgtagtgta tccattttca taaccttcat caaatgtaag atatagtgtt ttttgaccat
    22681 cttttgtagg tccattgtat agggcatcat agtcagaaaa tttaaattca atgtccgtat
    22741 ttacttctgg tgttttatgc ttattgtttg gtatataaaa ccaatcaaga gtagtgttat
    22801 ctaaagaaga tacatctaat ttattattat cattattagt agtggctttt gatggtttat
    22861 ctgttccgtc tgaaactatt acattggaag tatctttacc actatctatt ttttccttat
    22921 cttcttgtaa ctgtgtttcc ttattttgat tttcgttttg attgttttgt gaatttgaac
    22981 atccaacaat aaaaaaaata gaaatagaaa gtagtgttaa ataatgcaat acttttctaa
    23041 acattttgaa gctcctttct aaattaataa taattgcata taataataat tatatgatta
    23101 attacaattg catatagtat tattataatt ggaaattact attaataata gttatatctt
    23161 taaaaataag gtcacaatag tatgacaaag ggtgaataat caataaattt aaaaaaaaat
    23221 gaaaaaaata gttgaccata ttatgagaag atgttattat aataaatgtg ctcaacaaga
    23281 agtaacaaaa taacaagcac aaagaagtta attgaat
//
LOCUS       DAEHWM010000064        23241 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.065, whole genome shotgun sequence.
ACCESSION   DAEHWM010000064 DAEHWM010000000
VERSION     DAEHWM010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23241)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23241)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23241
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.065"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            153..899
                     /gene="cdtR"
                     /locus_tag="KNP36_002489"
     CDS             153..899
                     /gene="cdtR"
                     /locus_tag="KNP36_002489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family response regulator CdtR"
                     /protein_id="HBF0874351.1"
                     /translation="MDILIFDNDVCFGMKLKEKINNILIKEGFDNDVVRLYHNANLLL
                     KELTEKNKVRIYFIVVDAKYKISNELCDGLWIAQKIRESDYISPIIFLTNHIEMILGI
                     FDYRLEVMDFILKHDMEIAESKIKACIKIAHKRYIKEKNYRSNFFTIYSDFSLWKISF
                     DEVIYFETSTIPHKIKLVTTSRIFEFYKSLKSLPDLDACFIRVHKSFVVNKYHIVSLD
                     LKKNNIKMSNGHICRISNTYRNILKNIIKT"
     gene            1288..1470
                     /locus_tag="KNP36_002490"
     CDS             1288..1470
                     /locus_tag="KNP36_002490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874352.1"
                     /translation="MKKFRKHKSISNCISILLILYLTLGSLLPNNIYAQDLQSYSGKV
                     CNTTYKAPIERSEGFF"
     gene            1806..3373
                     /locus_tag="KNP36_002491"
                     /pseudo
     CDS             1806..3373
                     /locus_tag="KNP36_002491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021426623.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iota toxin protein Ib"
     gene            complement(4025..5026)
                     /gene="trpS"
                     /locus_tag="KNP36_002492"
     CDS             complement(4025..5026)
                     /gene="trpS"
                     /locus_tag="KNP36_002492"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HBF0874353.1"
                     /translation="MSEKKVIFSGAQPSGKMTLGNYLGAIKNWTELQDNYDCYYSIVD
                     LHAITVPQDPKVLRANTIELLAQYIACGLDPEKNTIFIQSHVKEHVELMWVLNTMTYM
                     GELSRMTQFKDKSQKSEANLNAGLFTYPVLMAADILLYQTDLVPVGDDQKQHLELARD
                     LANRFNNRFSPTFVVPEGYYPKGGARVMSLQEPTKKMSKSDSNENAFILLADDSDSIK
                     RKIKRSVTDSLGVVKYNDEQPGIKNLIDIYSNLSKKSVEEIVNMYEGKGYGIFKEDVA
                     EVVSEALRPIREKYVDLLNNKDYLEKIYSMGAEKAEKQARKTLRKVYKKVGFIERRY"
     gene            complement(5049..5747)
                     /locus_tag="KNP36_002493"
     CDS             complement(5049..5747)
                     /locus_tag="KNP36_002493"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HBF0874354.1"
                     /translation="MNVIGIIGAMDEEVSILVDLMDIRETIKKASLEFYKGILEGKNV
                     VLVKCGIGKVNSALCAQILISEFKVDAIVNTGVAGALNEKLDVNDIVISTDAIQYDVD
                     TTAFGDPKGVIPRMKTSVFKADERLIDAAYKSSVEEVKTHKVLKGRVVTGDKFINSKE
                     LKEELVNDFGGYCGEMEGGAIAHVCYLNNTPFVIIRAMSDKADGSADVTYDVFVHDAA
                     NNSKDIVLNMLKSI"
     misc_binding    complement(5790..6030)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(6121..7524)
                     /locus_tag="KNP36_002494"
     CDS             complement(6121..7524)
                     /locus_tag="KNP36_002494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HBF0874355.1"
                     /translation="MEKKKIGLWSLVFMNVSALYGIRWIAKSTASSFGLGLGAIPMWL
                     LFSFIYFVPGALICAELASTYQKGDGGLYDWVKEAFGEKYGFLVSWLNWTAKIFWYSS
                     FLTFLAVNVSYTIGNPALADNKMFVLILSLIIFWALSLIATKGISFTKIFTNTGALGS
                     TIPSAILIIFSFVAVFVLKKHDIASTYTIASMTPKLNMDAFVAISAIMFGLAGAETAA
                     NFITEIDKPEKNFPKAILISAGIVASLYVLGSIAITMIIPPDQITASKGVLDALSAVC
                     ASLGIGSWLVQLIAFGIAFSVLGAIVLYIASPIKMLFGSVKKGIFPDSLVEVNEHKIP
                     SKAVILQAIIVTIILLVTTLMPSVDAIYNVLVTMTALTALFPYVLLYASYIKLRKERP
                     DEIRPYTMAKSTSTCLGLAKMVLVVTVVGILLSAAPVMPTFAENVIYEIEMIGGGLLV
                     ILSGLWLWNRYEKKTAK"
     gene            8021..9097
                     /locus_tag="KNP36_002495"
     CDS             8021..9097
                     /locus_tag="KNP36_002495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0874356.1"
                     /translation="MKAQRLNAVLEQMKKDDISQMLVSDPTSIFYLTGVLIHPGERLL
                     ALYLNLNGNNKLFINELFPVSEDLGVEMVWFNDTQNPVEIITEHIDKNATMGVDKNWP
                     ARFLLNLIELGGGSKFVNSSYIIDTLRMCKDEEEKELMRIASKLNDKAMEQLKATVSG
                     ELTEKQLVGKLSKIYEDLGTDGFSFDPIIGFGPNGANPHGEPGNALVKPGDAIILDIG
                     CIKDNYCADMTRTVFYKEIPEKGREIFEIVLEANKRAEAIVKPGVRFCDIDAAARDYI
                     TEKGYGQYFTHRTGHSIGLEVHDKGDVSSINTDTVQPGMIFSIEPGIYLPGEFGVRIE
                     DLVLVTEDGCEILNKHDKEICVVG"
     gene            complement(9200..10042)
                     /locus_tag="KNP36_002496"
     CDS             complement(9200..10042)
                     /locus_tag="KNP36_002496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBF0874357.1"
                     /translation="MDKIKLIVDSACDLPDDIIEKYNIEVVGLNVSFGEESYISGKEI
                     DNETFYRKMSESKVLPKTSCPSPDKFLEAYHCQEESVLVINISSGLSGTYNSALLAKD
                     MFEKEGNNKKVEVIDSLSGSIGIGQLVLKAAILIKEGKEIEEIVSIINKYKDNPPFFG
                     TLETLENAIKGGRINPIAGKIINTLNFKAIIQVADGVVTPIDKARGEGNSLKKLITLV
                     ESKIKDKEEKVLFIGHANCPEKAQKVREVMEKDVKYKDVVICEIGSVMGTYTSKGAIL
                     ITAI"
     gene            10226..10798
                     /locus_tag="KNP36_002497"
     CDS             10226..10798
                     /locus_tag="KNP36_002497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0874358.1"
                     /translation="MKTNNMKQAILSSATNLIAKNGVQNTSLADIAKDVNISKGTLYY
                     HYASKDDIIYDIADTHLEVITSAILNCVKNVKSKNSQIEMVNLILEKISTIESRGRVH
                     MYLICEAITSNNDLKERIRLKYIEWRTTLKSEIVESLEKYNSSENEQDAESFSFLLMS
                     IVDGLVVQSLLKTEKIPYENIASFLVNHWI"
     gene            complement(10961..11233)
                     /locus_tag="KNP36_002498"
     CDS             complement(10961..11233)
                     /locus_tag="KNP36_002498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874359.1"
                     /translation="MLRERFVVRNHHNPHTSGCCGTGGEGCCGGDNHEHSHQHSHSHG
                     HEHEHVNGVGHDHNHDDGFSGTHEHSHEHTHTHGHEHSDGHTHEHK"
     gene            complement(11360..12232)
                     /locus_tag="KNP36_002499"
     CDS             complement(11360..12232)
                     /locus_tag="KNP36_002499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBF0874360.1"
                     /translation="MYGESKKLSIDNNIFLQYCLIILGMILSTLGINLYLAPAKLLSG
                     GVAGICVILYKLFGINQGISSFLMNIPIFIIARKYFDNKFLLISFVNMLLFSLALGLT
                     QDIAKYFPIDDTMLQCIYGGALTGIGMGLTFKARATAGGLDIIAAIMKRKYDIPMKNT
                     FLFINFFVVCAGAFLFGAKLVMYTLITMYIISFTMDIGKDCFDRKKSILLISNKYDEI
                     SKVIMNKMGRGVTFLEAEGAYTQNKKKMIYCIISANEIGKFKDLIYDMDSEAFISVNN
                     VEEVKGGGFKDKFL"
     gene            complement(12528..15635)
                     /locus_tag="KNP36_002500"
     CDS             complement(12528..15635)
                     /locus_tag="KNP36_002500"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HBF0874361.1"
                     /translation="MAKFKPLVDSSVKQAEAQVFDYWKDINILEKTLEKGKDDPSFVF
                     YEGPPTANGNPGVHHVLSRTLKDSVCRYKTMSGYQVKRKAGWDTHGLPVEIQVEKELG
                     LTSKQQIEEYGIAEFNQKCRESVFSFEKQWRIMTERMAYEVDLDNPYITLDNNYIESV
                     WWILNKFNKEGYIYEGHKILPYCPRCGTGLASHEVAQGYKEVKTNTVIAKFKKKDADE
                     YFLAWTTTPWTLPSNVSLTVNADVDYLKVKKGDEVYYVSKPLADKVLGEDYEVLEEMK
                     GKDLEGLEYEQLMPFVEVDKKAFFITVGDYVTTEDGTGIVHTAPAFGEDDYNTGKRYD
                     LPVIQPVDETGKFTSTPWEGRFVMEDGLDVEIIKWLASENKLYSKEKVVHNYPHCWRC
                     QTPLVYYAKPSWYIEMTKLKDKLIENNNGVKWFPSFVGEKRFGNWLENLNDWAISRTR
                     YWGTPLPIWRCECGHTDSVGSRAELAEKAIEDVNPETVELHRPYVDDIHLKCEKCGKP
                     MTRVTEVIDCWFDSGAMPFAQHHYPFENKENFDQLFPADYISEGIDQTRGWFYSLLAV
                     STFVLGKAPYKSVLVPDLVLDKDGKKMSKSRGNTVNPMELFDQYGADALRWYLLYVSP
                     PWTPTKFDMDGLKEIQSKFIGTMKNVYNFFTLYANTDDINPTEFFVEYKDRPELDRWI
                     LSKFNNLMKDVEENLAIFELNKTLRMIQDFINDDLSNWYIRRSRRRFWATELTEDKKA
                     VYNTTYELLHGLCRAIAPFAPYMSEEMYRNLTGEVSVHLAEYPKCNEELVDTKLEEKM
                     DLAKNLVTLGRASREVERIKVRQPLQKVLVDGKFEDTISDVVDLIKEELNVKEVIFAK
                     DLDEYMNFSLKPNFKEAGPLLGSKMNLFVGALSKLNAHETANKLEKGETLTVDLDGEA
                     FEFNKDLVLIGITAKEGFNVSVENNLFVILDTKLTEELINEGYAREFISKVQQLRKSN
                     NFEVLDNIVIEYCGDDEIAKAVDHFNEYIKSETLALEINRVDDKSLEEQNLNDHMTGI
                     KVIKK"
     misc_binding    complement(15728..15960)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(16135..16662)
                     /locus_tag="KNP36_002501"
     CDS             complement(16135..16662)
                     /locus_tag="KNP36_002501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DivIVA domain-containing protein"
                     /protein_id="HBF0874362.1"
                     /translation="MLTPIEIENKEFKKGLRGYRDEEVDEFLDIIKEDYESLCRENTA
                     LKEKLGLYQDQVNKYENIEETLKATLITAQSAAEDTCSAANKKAKIIVEEADLKARQI
                     IEQANNRVIEIRKEYDALVKEFKIFRNKFKSLLEDEIRSVDEIFYDVDEKCVNAFEGT
                     TVYNYSNDEAATTLE"
     gene            complement(16697..17482)
                     /locus_tag="KNP36_002502"
     CDS             complement(16697..17482)
                     /locus_tag="KNP36_002502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HBF0874363.1"
                     /translation="MDKLKLTNHIKDIDLKNKMFKVIDKANSCIKNYDVKSTEFLNPY
                     EVKNAVAILNSTNEIKYSVDGGYEQAERSTVFIYPFYMEYEDIEDTLRFLQIEGNFKF
                     KNISHKDYLGSILGLGIKREKIGDIIIHDSFCQVVVSSDICDFIIVNLEKVSRNNVIV
                     KEISRENIVNSSSKYKEVSFTVSSDRLDCVISGIYNISRQDSAKYINGEKVHVNYEKI
                     TSTSKIVKNDDLISIRGKGRAKVTQIGDITKKGKIKVQARLIV"
     gene            complement(17492..17749)
                     /locus_tag="KNP36_002503"
     CDS             complement(17492..17749)
                     /locus_tag="KNP36_002503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HBF0874364.1"
                     /translation="MGTIRIALYYLLDIIAWMIVIKSLMTWFPNGRQSKIFDILENLT
                     EPIEGPIRSIMYKYTNGPIDFSPLIAIVLLMFLRQLVLVIF"
     gene            complement(17768..18226)
                     /locus_tag="KNP36_002504"
     CDS             complement(17768..18226)
                     /locus_tag="KNP36_002504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HBF0874365.1"
                     /translation="MSNGIISKFKNWIVDEEEDYIEDEYESGMDDIVQEEEMNSGFST
                     AKANKIVNLHTTSQMKVVIVEPKVYDEAATIADHLKQRRAVIVNLEGLTNSEVRKSIF
                     NFMNGAVYVLDGSIQKVSKSIFILAPNNVDIDANMKKELESKAFFPWQNK"
     gene            complement(18266..18970)
                     /locus_tag="KNP36_002505"
     CDS             complement(18266..18970)
                     /locus_tag="KNP36_002505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HBF0874366.1"
                     /translation="MGSIKDNLSEIRNKIDKAAKKVDRDSKEITLLAVTKTVDVDLVN
                     EAMREGITSVGENKPQELARKYDIIGDKLNWHLIGTLQTNKVKYIIDKVCMIHSLDRI
                     ALCEEIQKRAEQINREIDCLVQVNISKEESKHGLDREEVVDFVKEVSEKYKNIKIKGL
                     MTMAPFIEDEDEIRGVFKGLKDLSKQIKELNIPNVGMDVLSMGMSHDYEIAIEEGATI
                     VRVGTSIFGERNYNKK"
     gene            complement(18980..19615)
                     /locus_tag="KNP36_002506"
     CDS             complement(18980..19615)
                     /locus_tag="KNP36_002506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874367.1"
                     /translation="MKKVKYTRLVILGILIYLVFNILVMIISKNVDTLVLKNEKVDAK
                     IHVKGTIEKDANDQSNYLSTYISKEDSNNFEKNQNVIIEYHEQKLDAKVYKIYENNNK
                     IMVKLKISNQIVANQDTSVEEFDIIYNQMECLKIPKTSIKTKDNKRGVYVIDEQSQSV
                     KFVILEGITYENESSVFVDYYKNDINGVTSVNLYDKIILRPNSINTNIRIK"
     gene            19996..21036
                     /locus_tag="KNP36_002507"
     CDS             19996..21036
                     /locus_tag="KNP36_002507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0874368.1"
                     /translation="MSEILLGTGLLLLVLCCFTIFSYKAPYGMKAMGALANAACATFL
                     VEAFNLSLLGDVLGMEFFRSVGAANGSLGGVAAAILVPLALGVSPVYAVLIGLSCLDF
                     SILSGFVAGYFVSFLIKFIEKKVPPGVDLVVVILLCAPLSRLIASNVDPLVNSTLLQI
                     GQVLIEATNISPIIMGIILGGLITVVGTSPLSSMALTSIIGLTGLPMAIGALGAFGSA
                     FMNSTLFAKLKLGSKKDIISVAIEPLTQSDIISANPIPIYSTNFFGGAFSGIIVALMG
                     LVNMTPGTATPVAGFAIMFAYNPVQQVLITAGLCALFNVIAGFLGSKIFSTFKVLTAG
                     EIRGTDVEEEIA"
     gene            complement(21499..22854)
                     /locus_tag="KNP36_002508"
     CDS             complement(21499..22854)
                     /locus_tag="KNP36_002508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009170073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HBF0874369.1"
                     /translation="MNVGNILETIKMIDEEQLDIRTITMGISLLDCIDPDGDKAREKI
                     YNKIMSSAKDLVKVGKDIEREFGIPIVNKRVSVTPISIIAGATDENDYVKFAQTLDKA
                     AEDLGIDFIGGFSALVQKGYTKGDKILIKSIPKALASTNKVCASVNVGSTRCGINMDA
                     VKEMGEIIKETAELTKDAKGFGCAKLVVFCNAVEDNPFMAGAFHGVGEADRIINVGVS
                     GPGVVKRALEKVKGEPFDVVSETVKKTAFKITRVGQLVAKEASSRLDVPFGIIDLSLA
                     PTPAIGDSVANILEEMGLEVVGTHGTTAALALLNDAVKKGGVMACSHVGGLSGAFIPV
                     SEDAGMIDAVIKGALSIDKLEAMTAICSVGLDMIAVPGNTTAGTLGAMIADEAAIGMI
                     NNKTTAVRIIPAPGCDVGDMVEFGGLLGRAPVMPINTNSSELFTQRGGRIPAPIHSFK
                     N"
     gene            complement(22880..23149)
                     /locus_tag="KNP36_002509"
     CDS             complement(22880..23149)
                     /locus_tag="KNP36_002509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HBF0874370.1"
                     /translation="MKAILTVIGKDKPGIVAGISDELYKQNINIVDISQKILQDYFTM
                     IMIVDLEKSLNSFEKTVEDLVERGKKLSVDVKIQREEIFNSMHNL"
BASE COUNT         7862 a         3816 c         2713 g         8850 t
ORIGIN      
        1 actataagta taagatatac tatataaaca agcataaata taccttaatt ctaactatcc
       61 ttaatcttat ttatctccta gtgttatttt atgtattttc tataaaatac ttttgttttt
      121 ttacttttga attttttata ggagggtatt tagtggatat attaatcttt gataatgatg
      181 tttgttttgg aatgaaacta aaagaaaaaa taaataatat tttaataaaa gaaggttttg
      241 ataatgatgt tgtaagatta tatcataatg caaatttgtt attaaaagag cttactgaaa
      301 aaaataaagt aagaatatat tttatagttg tagacgcaaa atataagata agtaatgaat
      361 tatgtgatgg attatggata gcacaaaaaa ttagagaatc agattatatt agtccaatca
      421 tatttcttac aaatcatata gaaatgattt tagggatctt cgattatagg ttagaagtta
      481 tggactttat actaaaacat gatatggaaa ttgctgaaag taaaataaaa gcttgtatta
      541 aaattgctca caaaagatac attaaagaaa aaaattatcg ctctaatttt tttactatct
      601 attcagattt ctcactatgg aaaatttcat ttgatgaagt tatatatttt gaaacaagca
      661 ctattccaca taaaataaaa ttagtgacta cttctagaat atttgaattc tataaaagtt
      721 taaagtcttt accagattta gatgcatgct ttatccgtgt acataaatct tttgtagtta
      781 ataaatatca tattgtttct ctcgacctaa agaaaaataa tattaaaatg agtaatggcc
      841 atatatgtcg tatatctaat acatatagaa atattttaaa gaatattatt aaaacataat
      901 aaatagaaaa aggagatgtc tcaagataaa aatttgaacc atctcttttt tatacaaaaa
      961 gagtaatccc taagaatcct ctatataata atcatattgt gaaaaaacac atactgacta
     1021 tatcatatat aactactatt agatattata acaattgttc ctagattatg attcgataag
     1081 atagctcatt aaatcataaa agtacgaaat agtctcttta aaatattcag ttgttatttt
     1141 gtactgacat atcatataaa tacatatttt tatgatatat acctacatat tttatgaaat
     1201 ttatataaaa aattcttatt tagattatat aatctaaata aattaaaatt caaaagttaa
     1261 ctaaactaat atttgtaggg agaataaatg aaaaaattta ggaaacataa aagtattagt
     1321 aattgtatat ctatattgtt gatattatat ctaactttag gtagtttgtt acctaataac
     1381 atttatgcac aagatttaca aagctatagt ggaaaagttt gtaatactac ttacaaggct
     1441 cctatagaaa gatcagaagg atttttttaa agataaagaa aaggctaaag aatgagaaag
     1501 aaaagatcaa aaacttgaaa aatctgaaaa agaagtatta ggatcatata aaaaagattc
     1561 tatagagata agcaaatatt ctcagacaag aaattatttt tatgattatc aaatagaagc
     1621 aaattcttga gaaaaagaat atagagaact tcgaaatgct atatcaaaaa ataaaataga
     1681 taaacctatg tatgtatatt attttgaatc tccagaaaaa tttgcattta ataaagtaat
     1741 aagaacaaaa aatcaaaacg aaatttcatt agaaaaattt aatgagttta aagaaactat
     1801 acaagacaaa ttattaccat acaacagata attcaactgc tgttcaaaat agcaatggat
     1861 aatcatgaaa tactggatta agtataaaca aaggagaatc tgcatatata aatgcaaata
     1921 ttagatacta caacacaggt actgcaccta tgtacaaagt gacaccaaca acaaatttag
     1981 tgttagatgg agatgcatta tcaactatca aagcacaaga aaatcaaatt ggcaataatc
     2041 tatctcctgg aaatacttat ctcaaaaaag gattttcacc tatggctctt aacacaatgt
     2101 atcaatttag ttctagactg attcctataa attataatta attaaaaaaa ttagatgatg
     2161 gaaagcaaat taaattagaa acaacacaag taagtggaaa ttttggtaca aaaaatggtt
     2221 ctggacaaat agtaacagaa tgaaatagtt ggtaagacga tataggtcaa attgacagta
     2281 tttctgtatc tattatatta gatacagaaa atgaatctta caaaagaaga attactgcta
     2341 aaagtttaca ggtcccagaa gataaaacac ctgaacttac aattggagaa gcaattgaaa
     2401 aaacttttgg cactactaaa aaagatggtt tgttatattt taataatata ccaatagatg
     2461 aaagttgtgt tgaactcata tttgatgata atataggcaa taagattaaa gacagtttaa
     2521 aaactttgtc tgataaacaa atatgtaatg ttaaacttga aagaggaatg aatatactta
     2581 taaaaacacc aacttacttt actaattttg atgattacaa taattaccct agtatatgga
     2641 gtaatgttaa tactacaaat caagatggtt taaaaggctc agcaaataga ttaaatggtg
     2701 agacgaagat taaaatacct atgtctgaac taaaacctta taaacgttat gtttttagta
     2761 aaattcaaaa aatcctttaa catataattc aataattgta aatataaaag taaaagaaga
     2821 aaaaacggat tatttggtac tagaacaagg atatacaaaa tttagttatg aatttgaaac
     2881 tactgaaaaa gattcttcta atataaatat agcattaatt gatagtgata caatatactt
     2941 agataactta tctattacag agctaaatag tactcctgaa atacttgatg aaccagaagt
     3001 taaaattcca actgttcaag aaataatagt tacacataaa atatattctg cagattttaa
     3061 atttaatcca agtacaataa aggcttatat aaatggtatg tattttacac caacataaac
     3121 taataaagaa gctctcgatt atgtccaaaa atatagagtt gaagctactt tacaatattt
     3181 tggatttaaa gatattgaaa ctaaagataa agaattgcgt aattatttag gagatacaaa
     3241 tcaacctaaa actgattgtg ttaatcttag gagttatttt acaggtggag aaaatattat
     3301 gacatacaag aaattaagaa tatatacaat tactcaagat gatagagagt tattggttct
     3361 tagtgttgat tagtatcaaa tgatttaaat ttatccccac aatacaatat gtatttacct
     3421 tataaagtat taaaaaatta actttataag gtatttttta tttaaatatt atcttcttct
     3481 aatatattct tttttagaac tatattgtat taaaaagata attatctgta tcatatcacc
     3541 tatatataaa cataaattca tttaattata taaatttaaa aaatattttt ttgatatatt
     3601 attgacaatt ttcattataa gagttaaaat taactcataa attacatatt gggtataaaa
     3661 tacaatgtat gttagaagtt gtttcagaag gctatggttt tctgattttt ttatgctcag
     3721 tagtgatatg caaaaaagac aaagttgaca tcagttaact tttaccttta ttctactttc
     3781 cccaaagtaa gaataatcta acccctttga gatgagcaaa agctcatctt tttttattat
     3841 caaaagatgc tgtctcaaaa tagagataat cctctttttc attgttgaaa tgattaaaat
     3901 atattttatt tcatacaaaa aagagtgcct catgaacaaa agttcacttt gagactctct
     3961 ctttcatatc atataccttt ttaataactt taaaatttat ttatcaagta aagatagcta
     4021 ataattagta tcttctctct ataaatccaa cttttttata aacttttcta agagtttttc
     4081 tagcttgttt ttcggctttt tctgctccca tactatatat tttttctaaa taatctttat
     4141 tattaagaag gtcaacatat ttttctctta taggtcttaa agcttctgat actacttcag
     4201 ccacatcttc tttaaatatg ccataaccct ttccttcata catgtttaca atctcttcta
     4261 cactcttttt acttaaatta gaatatatat caattagatt tttaatacct ggttgttcat
     4321 cattgtattt tacaacacct aaagaatcag taacacttct ttttatcttt ctctttatag
     4381 aatctgaatc atctgctaat agtataaatg cattttcatt tgaatcggat ttactcattt
     4441 ttttagttgg ctcttgcaaa ctcatcactc ttgctccacc ttttgggtag tatccttctg
     4501 gaactacaaa agtaggtgaa aatctattat taaatctatt tgctaaatca cgagctaatt
     4561 ctaaatgttg tttttggtca tctccaactg gaactaggtc agtttgatac aacaatatgt
     4621 cagcagccat aagaactgga tatgtgaata aacctgcatt tagatttgct tcactctttt
     4681 gtgatttatc tttgaattga gtcattctac ttaattcacc catataagtc atagtattca
     4741 atacccacat aagttcaaca tgctctttga catgtgattg tataaatata gtattttttt
     4801 ctgggtctaa tccacaagct atatattgag caagtaattc tatagtattg gctcttaaaa
     4861 ctttagggtc ttgaggtact gttattgcat gcaaatcaac tatactataa taacaatcat
     4921 aattgtcttg aagttcagtc cagtttttta tagctcctaa ataatttcct aaagtcattt
     4981 tgcctgatgg ctgtgcacca ctaaatataa cttttttttc actcattttt ttgtacctcc
     5041 ttatatattt atattgattt taacatattt aaaactatgt ctttagagtt attggcagca
     5101 tcatgtacaa atacatcata agtaacatca gcacttccat ctgccttatc agacattgct
     5161 cttattatta caaatggagt attatttaaa tagcatacat gagctatagc tccaccttcc
     5221 atttctccac aatatccacc aaaatcattt actaattctt cttttaattc tttagaattt
     5281 ataaatttat ctcctgtaac tactcttcct tttaatactt tatgagtctt tacttcttcc
     5341 acagaagatt tgtaagcagc atctataagt ctttcatctg ctttaaatac agaagtcttc
     5401 attcttggta taactccctt agggtctcca aatgctgtag tgtctacatc atactgtata
     5461 gcatcagttg atattactat atcattaaca tcaagttttt cgtttaaagc tcctgcaaca
     5521 cctgtattaa caatagcatc aaccttaaat tcgcttatta gtatctgggc acaaagagca
     5581 gagttaacct tacctatgcc acactttact aacactacat tcttaccttc caaaattccc
     5641 ttataaaatt ctaagctagc tttttttata gtctctctaa tatccattaa atcaactaaa
     5701 atactaactt cttcatccat tgcacctata attcctatta cgttcatttt tcctcctaaa
     5761 ttttctatat taaaaaatcc gtcctaaatc aataggacgg atatattttc cgtggtacca
     5821 cctaaattta tatacactca aaattgaata tatatatctt aatatatgct ataacgtgca
     5881 tacacgatat caaatactct gtaatattaa attacatttc attttactcc tcaaagaccc
     5941 attcaataaa tactttttat taagttctca gcatccttaa ttctctgtgc aaaaatatat
     6001 ttatttacta tttcttatct caggatttaa tttattaatt tctttatttt ataatattcc
     6061 ttacactata aattgtcaac tatatattat aatatccaaa agaaattttt aaaatacatt
     6121 ttatttagct gttttctttt catatctatt ccataaccat agaccagata atataactag
     6181 aagacctcca ccaatcatct ctatctcata tataacattt tcagcaaatg taggcataac
     6241 tggtgctgca gataataata tacccactac agttacaact aaaaccattt ttgctaaacc
     6301 taggcaagta cttgttgatt ttgccatagt ataaggtcta atttcatctg gtctctcttt
     6361 tcttagttta atataagaag catataacaa tacatatggg aataatgcag ttaatgctgt
     6421 catagttaca agaacattgt atatagcatc aacagaaggc attaatgtag tcaccaatag
     6481 tattatagta actattattg cttgaagtat aactgcttta gaaggtatct tgtgttcatt
     6541 tacctctact aaactatctg gaaatattcc ttttttaaca ctaccaaata acatttttat
     6601 tggtgatgct atgtaaagaa ctattgctcc taatactgaa aaagctatac caaaagctat
     6661 taattgaacc aaccaagaac caattcctaa agacgcacaa acagcagaaa gtgcatctaa
     6721 tacaccttta gaagcagtaa tttggtctgg tggtattatc attgttattg caattgaacc
     6781 taatacatat aatgaagcta ctattccagc tgatattaat attgccttag ggaagttctt
     6841 ttcaggctta tctatttctg ttatgaagtt agcagcagtc tctgctcctg ctaaaccaaa
     6901 cattatagct gatatagcaa caaatgcatc catattaagt tttggagtca ttgaagctat
     6961 tgtgtatgta gaagctatat catgtttttt caacacaaat actgctacaa atgaaaatat
     7021 tataagtata gcacttggta ttgttgaacc taatgcacct gtattagtaa atatttttgt
     7081 aaaacttatt cctttagttg ctataagaga taatgcccag aatattatta aagataatat
     7141 aagtacaaac atcttattat cagcaagggc tggatttcct attgtataag aaacatttac
     7201 tgctaagaaa gttaaaaatg aagaatacca aaatatttta gctgtccagt ttaaccaaga
     7261 aactaaaaat ccatactttt ctccaaaggc ttccttaacc caatcgtaaa gacctccatc
     7321 acctttttga tatgtagaag ctaattcagc acaaattaaa gctcctggta caaagtatat
     7381 aaatgagaat aataaccaca taggtattgc acctaatcct aaaccaaagc ttgatgctgt
     7441 agatttagct atccatctta taccatataa agctgataca ttcataaata ccaaactcca
     7501 taggcctatt tttttctttt ccatcctaat ttaatttccc ctctctatta attattttaa
     7561 atttaatttc aaaattaata aaatagattc attattatta aactgatatt tttcaaaata
     7621 tttgcatatt caaaaacagt tttaataata aaccttaaat actttgaaat caaatcttat
     7681 taaaaatgat aaatttaaaa gttttaccac tttaattcta atgatactaa atttttaaaa
     7741 ttgtttcaat attattttat tataaaattt tatttattat ttttcattag tatataaaaa
     7801 gataaaatac ataactttat agacttaatt tattactttt atagaatttt cacaataaaa
     7861 agtcatttta cttccgtatt taatgcaaaa gtagaaatta aacttaatat aaaaaatata
     7921 taacaaattt tttttatatt tctagaagaa aagtatactc ttttttgttt aataatgcta
     7981 aaattgattt gtattgaatt ttgattagga ggaaattatt atgaaagctc aaagattaaa
     8041 tgctgtactt gaacaaatga aaaaagatga tatttctcaa atgttagtaa gtgaccctac
     8101 ttctatattt tatcttacag gagtactaat ccatccaggc gaaagactat tagcattata
     8161 cttaaattta aatggcaata ataaattatt tataaatgaa ttattcccag tttcagaaga
     8221 tttaggtgtt gaaatggttt ggtttaatga tactcaaaat ccagtagaaa taataactga
     8281 acatatagac aaaaatgcta ctatgggtgt tgataaaaac tggccagcta gattcttatt
     8341 aaacttaata gaattaggtg gaggaagtaa gtttgtaaat tcatcttata taatagatac
     8401 tttaagaatg tgtaaagatg aagaagaaaa agagttaatg agaatagctt caaaattaaa
     8461 tgacaaggct atggaacaac ttaaagctac tgtttctggt gaacttacag aaaaacaact
     8521 tgttggtaaa ttatctaaaa tatatgaaga cctaggtact gatggatttt catttgaccc
     8581 tattataggt tttggaccta atggagctaa tccacatggt gaacctggaa atgcacttgt
     8641 gaaaccagga gatgcaataa tcttagatat aggttgtata aaagataact attgtgctga
     8701 tatgacaaga actgtattct ataaagaaat acctgaaaaa ggtagagaaa tatttgaaat
     8761 agttcttgaa gctaataaga gagctgaagc tattgtaaaa ccaggtgtta gattctgtga
     8821 tatagatgct gctgctcgtg actacataac tgaaaaggga tatggacagt acttcactca
     8881 tagaactggt cactctatag gacttgaagt tcatgataaa ggagatgtat cttctataaa
     8941 tacagatact gtacaaccag gaatgatatt ctctatagag ccaggtatat atttaccagg
     9001 tgagttcgga gttagaatag aagatttagt acttgttact gaagatggtt gtgagatatt
     9061 aaacaaacat gacaaagaaa tatgtgtagt tggttaattc taaaatcaat ttgataaaat
     9121 taaaaagcca tataaaaatg ttttaaacat ttttatatgg ctttaatttc tcaatctatg
     9181 atttatttca atccattatt tatattgcag ttattaagat tgcacccttt gaagtatatg
     9241 tccccatcac tgaaccaatt tcacagatta caacatcttt gtattttaca tccttttcca
     9301 taacttccct taccttttga gccttttctg ggcaattagc atgtcctata aataaaacct
     9361 tttcttcttt atctttaatt tttgactcta ctaaagtaat cagctttttc aaactgtttc
     9421 cttcacctct tgccttatct ataggagtta caacgccatc tgcaacttgt attatcgcct
     9481 taaaatttaa ggtatttata atttttcctg ctattggatt tattctacca cccttaatag
     9541 cattttctaa agtttcaagt gttccaaaaa atggaggatt atctttatat ttatttatta
     9601 ttgaaacaat ctcttcaatt tcttttcctt cttttattaa tattgctgct tttaacacta
     9661 attgtcctat tccaattgac ccactaagtg aatctataac ctcaactttc ttgttatttc
     9721 cttccttttc aaacatatct tttgctaaaa gtgcactatt ataagtccca gataatcctg
     9781 aacttatatt aatcactaat acactttctt cctgacaatg gtatgcttct aaaaatttat
     9841 caggagaagg acatgatgtt tttggtagta ctttactctc actcattttt ctatagaaag
     9901 tttcattatc tatttccttt ccagatatat aactttcttc tccaaaagat acatttaaac
     9961 caacaacttc tatgttgtat ttttctatta tatcatcagg taagtcacat gcactgtcca
    10021 ctatcaattt tattttatcc atattaacct cactataaga tattatttta tttattcagt
    10081 cggtcgtacg accgatttaa ttattatttt atatattgaa tgaaaaaaag tcaatagata
    10141 tagattctcg ctttattgac aataaatatc cataagctta taatgttatt aatttgttat
    10201 aaatatacat ggaaaggtag gttttatgaa aacaaataat atgaaacagg ctattttatc
    10261 atctgcaacc aatttaatag ccaaaaatgg agttcaaaat actagccttg ctgatattgc
    10321 aaaagatgta aatataagta aaggtacttt gtattatcac tacgcatcta aagatgatat
    10381 tatatatgat attgcggata ctcatttaga agttataact agtgctatac taaactgtgt
    10441 aaaaaatgtc aaatcaaaaa attctcaaat agaaatggtt aacttaatct tagagaaaat
    10501 atctactata gaaagtcgtg gtagggtaca tatgtatctt atttgtgagg caattacttc
    10561 aaataatgat ttaaaggaaa gaataagatt aaaatatatt gaatggagaa ctactcttaa
    10621 atctgaaatt gttgaatcac tagaaaaata taatagtagc gaaaatgaac aggatgctga
    10681 atcattttct tttttactca tgtcaatagt tgatggttta gttgtccaaa gtttattaaa
    10741 aacagaaaaa ataccttatg aaaatatagc ttctttttta gttaatcatt ggatttaaac
    10801 ttaatactta gataattaat aaaagtgaac tatttaagtt atctacttta acagttcact
    10861 ttcttattta ttctcaataa tttttactta aaacattcaa tttttattta aaccttcatg
    10921 gaatcacaaa ataaaaatct cttataaatt taaaatgttt ttatttatgt tcatgtgtat
    10981 gcccatctga atgttcatga ccatgtgtat gtgtatgctc atggctatgc tcatgagtac
    11041 ctgaaaaacc atcatcatga ttatggtcgt gacctacacc atttacatgc tcatgttcat
    11101 gcccatgact gtgagaatgt tgatgtgaat gttcatggtt atctcctcca cagcatcctt
    11161 ctcctccagt cccacaacac ccacttgtat gtggattatg atgatttctt actacaaatc
    11221 tctctcttaa cataattctt atacctccta gtatattatt gagtacttca tgtaccccat
    11281 taactacagt atacatctaa ctaggtataa tctcaataca tatggcattt tttaacatat
    11341 ataattaaca tatataatct taaagaaatt tatccttaaa acctccacct tttacttctt
    11401 caacgttatt gacagaaata aaagcttcac tatccatatc ataaattaaa tctttaaatt
    11461 tacctatttc atttgcagat attatgcaat aaatcatctt tttcttattt tgtgtatatg
    11521 caccttctgc ctccaaaaaa gtgactcctc tacccatttt attcattatc actttggata
    11581 tttcatcata tttatttgat attaaaagta tagatttttt tctatcaaag caatcttttc
    11641 ctatatccat agtaaaagaa attatataca ttgtaattaa agtgtacatc accaatttag
    11701 ctccaaataa aaaagctcct gcacatacta caaaaaaatt aataaataaa aatgtatttt
    11761 tcataggtat atcatacttt cttttcatta tggctgctat tatatcaagt cctccagcag
    11821 tagctcttgc tttaaaagtt aaccccatac ctataccagt taatgcacca ccataaatac
    11881 actgtagcat agtatcatct attgggaaat atttagcaat atcttgtgtt agccccagtg
    11941 ctagagaaaa tagtaacata ttgacaaaac ttattagcaa aaatttatta tcaaaatact
    12001 ttctagctat aataaatatt ggtatgttca tcaagaaact tgatattccc tgattaatac
    12061 caaataattt gtataatata acacaaattc cagctactcc tccacttaat aacttggctg
    12121 gtgctagata taaatttatt cctaaggttg atagaatcat acccaatata ataagacaat
    12181 attgtaaaaa tatattatta tcaatactta gctttttact ttcaccatac atcaaaacgc
    12241 acccctttgc ataataaata aaccaccctg cataacacac gataaattta caaataaatt
    12301 tatcagaagt agtttcctaa aaatattatt catcctcact taaacgttta ttcattaata
    12361 ttctatcaca tgacataaat aatttatatg atttatatag atttatttat tgtaaatttt
    12421 ggaatattaa aacattttat tgaatagata attatattac ataaaaaatc cctatagaaa
    12481 tctataaact aatttctata gggattttgg ttaactaact attattttta tttttttata
    12541 acttttatac ctgtcatatg gtcatttaag ttttgttcct ctaaagattt atcatctact
    12601 ctgtttattt ctaaagctaa agtttcagac ttgatatatt cattaaaatg gtcaacagcc
    12661 ttagcaattt catcatcacc acagtattct attactatat tatctaatac ttcaaagtta
    12721 ttagattttc ttaattgctg tactttagat ataaattctc tagcataacc ttcattaatt
    12781 aactcttcag ttagcttagt atctagtata acaaaaagat tgttttcaac agatacatta
    12841 aatccttcct tagcagttat acctattaat actaaatcct tattaaattc aaaagcttca
    12901 ccatctaaat caactgttaa agtctcacct ttttcaagtt tattagcagt ttcatgagca
    12961 tttaatttac ttaatgctcc aacgaataaa ttcatcttag aacctaataa tggccctgct
    13021 tccttaaagt ttggttttaa actaaagttc atatactcat ctaaatcctt agcaaatatt
    13081 acctctttaa cattaagctc ttcttttatt aaatcaacta catcacttat tgtatcttca
    13141 aacttaccat ctactaacac tttttgtaat ggttgacgaa cttttattct ttctacttct
    13201 cttgaagctc tacctaaagt aactaagttt ttagctaaat ccattttttc ttctaattta
    13261 gtatctacta actcttcatt acatttagga tattcagcta aatgaacaga tacttctcct
    13321 gttaagtttc tatacatttc ttctgacata tatggtgcaa atggagctat agctctacaa
    13381 agaccatgta acaattcata agttgtattg tacactgctt ttttatcttc tgttaattca
    13441 gttgcccaga atcttcttct tgaacgtctt atataccagt tagataaatc atcatttata
    13501 aaatcttgta tcattcttaa agttttattt aactcaaata tagctaaatt ttcttctaca
    13561 tctttcatta aattattgaa cttagataat atccatctat caagttctgg tctatcttta
    13621 tattctacaa aaaattcagt tggatttata tcatctgtgt ttgcatataa agtaaagaag
    13681 ttatatacat tcttcatagt acctataaat ttactttgga tttcttttaa tccatccata
    13741 tcaaatttag ttggagtcca tggtggagaa acatatagta aataccatct taatgcatct
    13801 gctccatatt ggtcaaataa ttccattgga tttactgtat ttcctcttga tttactcatt
    13861 ttcttaccat ctttatcaag tacaagatct ggaactaaaa cactcttata tggtgctttt
    13921 cctaatacaa atgttgatac tgcaagtaat gagtagaacc aacctctagt ctggtctata
    13981 ccttctgata tatagtcagc tgggaacaat tggtcaaagt tttccttatt ttcaaatgga
    14041 tagtggtgtt gagcaaatgg catagcccca ctatcaaacc aacagtctat aacctctgtt
    14101 actcttgtca ttggttttcc acatttttca cattttaagt gtatatcatc tacatatggt
    14161 ctatgaagtt caactgtttc tggatttaca tcttctatag ctttttcagc taattcagct
    14221 cttgaaccaa ctgaatctgt atgaccacat tcacatctcc atataggaag tggagttccc
    14281 caatatctag ttcttgatat tgcccagtca tttagatttt ctaaccagtt tccaaatctc
    14341 ttctctccta caaaacttgg gaaccatttt acaccattat tattttctat taatttatct
    14401 ttaagtttag tcatctctat ataccagctt ggttttgcat agtatactaa tggagtttga
    14461 catctccagc agtgtggata attatgaact actttttctt tgctatataa tttattttca
    14521 gaagctagcc attttattat ttcaacatct agcccatctt ccattacaaa tctaccttcc
    14581 caaggagtag atgtaaattt accagtttca tctactggtt gaataactgg taaatcatat
    14641 cttttacctg tgttgtagtc atcttcacca aatgctggtg ctgtatgaac tataccagtt
    14701 ccatcttcag tagttacata atctcctact gtaataaaaa atgctttttt gtcaacttct
    14761 acaaaaggca ttaattgttc atattctaaa ccttctaggt ctttaccttt catttcttct
    14821 aaaacttcat aatcttcacc tagtacttta tcagctaaag gtttagatac ataatatacc
    14881 tcatcacctt ttttaacttt taaataatct acatcagcat ttactgttaa tgaaacgttt
    14941 gatggtaaag tccatggagt tgttgtccat gctaagaagt attcatcagc atcttttttc
    15001 ttaaatttag ctataactgt attagttttt acttctttat atccttgtgc aacctcatga
    15061 ctagcaagac cagttccaca tcttgggcaa taaggaagta ttttatgtcc ttcatatata
    15121 tatccttctt tgttgaattt gtttagtatc caccatacag actctatata gttattatct
    15181 aaagttatat atggattatc taaatcaact tcataagcca ttctctcagt cattattctc
    15241 cattgttttt caaatgagaa aactgactct ctacattttt ggttaaattc agctattcca
    15301 tattcttcta tttgttgctt gctagtaaga cctaactctt tctctacttg tatttcaact
    15361 ggtaatccat gtgtatccca accagctttt ctctttactt gataaccaga cattgtttta
    15421 tatctacaaa ctgaatcttt aagcgttcta gataaaacat ggtgtactcc aggatttcca
    15481 ttagctgttg gaggtccttc atagaatacg aaacttgggt catctttccc tttttctaaa
    15541 gttttttcaa gtatatttat gtctttccaa taatcaaaaa cttgtgcttc tgcttgtttt
    15601 acagaactgt ctaccaatgg cttaaatttc gccatgtaaa tcaccctttc ctactaaata
    15661 ttataattcc aaaatttttt attctttcac ataaatttaa atactaaaaa actcgccccc
    15721 tttaaaccaa agggacgagt tataaatcgc gttaccaccc taattctata tgtaaactaa
    15781 atactagcta catataacac tctaatagta taacggtact aaccggcaca gcttagtaga
    15841 atttaatcgt tcagcctgca gctcaagagt gatttttatc tttataaatt cattggttct
    15901 cagcataccc aattctctgt aaaattatct aaagataaat gtctctatca acgcttttaa
    15961 aaatttatct gtgtttatat gaaattctat aacaaataat ttgaatagtc aatatatttt
    16021 tgaaaaatat aataatttct atttttctta catttttatc ctatttttaa tctttgttat
    16081 agatttctca aactcacaca attattctac ataaaaaata aacaaattac aagcttattc
    16141 taaagttgta gcagcttcat cattactata attatacact gttgttcctt caaatgcatt
    16201 tacacatttt tcatctacat cataaaaaat ctcatcaaca cttcttattt catcttctaa
    16261 cagtgattta aatttatttc taaatatctt aaattctttg actaaagcat catactcttt
    16321 tcttatctct ataacacggt tattagcttg ttctataatt tgtctagctt ttaaatcagc
    16381 ttcttcaaca attatcttag cctttttatt agccgcgcta caagtgtctt ctgctgcact
    16441 ttgagcagtt attaaagtag cttttagtgt ttcttcaata ttttcatact tgtttacttg
    16501 gtcttgatat aaccctaatt tttctttaag agctgtattt tccctacata gagattcata
    16561 atcttccttg atgatatcta aaaattcatc aacctcttca tctctatacc ctcttaaacc
    16621 ttttttaaac tctttatttt ctatctcaat tggagttagc attacatttc ctcccagcta
    16681 taatttaaat tagtccttat acaattaatc ttgcttgaac ttttattttt ccttttttag
    16741 taatatctcc tatttgtgtt accttagctc ttcctttgcc tctaatagaa atcaaatcat
    16801 cgttttttac tattttagaa gttgaagtta tcttttcata attgacatgg actttttctc
    16861 catttatgta ttttgcacta tcttgtctag atatattgta aataccactt atcacacaat
    16921 ctaacctatc tgaagatact gtaaatgata cttctttata ttttgaagaa ctattaacaa
    16981 tattttctct ggaaatttcc tttacaatta cattatttct tgaaaccttt tctaagttta
    17041 caattataaa atcgcaaata tcactactta caactacttg acaaaagcta tcatgtataa
    17101 ttatatctcc aattttttct ctttttatac ctagacccag tattgaccct aagtaatctt
    17161 tatgagatat atttttaaat ttgaaattcc cttctatttg taaaaatcta agagtatctt
    17221 ctatatcttc atattccatg taaaatggat aaataaatac agtgcttctt tcagcttgtt
    17281 cataacctcc atccacactg tattttattt catttgtaga atttaatatt gctacagcat
    17341 ttttcacttc atatggatta agaaactccg tagacttaac atcatagttt tttatacaac
    17401 tattagcctt gtctatcact ttaaacattt tatttttcaa gtctatatcc tttatgtgat
    17461 ttgttagttt taatttatcc atcctatcac cttagaatat aaccaatact aattgtctta
    17521 ggaacatcaa taatactatt gcaattaaag gagaaaaatc tataggtcca tttgtatatt
    17581 tatacattat agaccttatt ggcccttcta ttggctctgt aagattttcc aaaatatcaa
    17641 aaattttact ttgtcttcca tttggaaacc aagtcatcaa gctttttata actatcatcc
    17701 atgctattat atctaaaaga taataaagtg caattcttat tgttcccata tattaaccgc
    17761 ctttttacta tttattttgc caagggaaga atgctttact ttctaattct tttttcatat
    17821 ttgcatctat atccacatta ttaggagcta gtataaatat tgatttagaa accttttgta
    17881 tacttccatc taagacataa actgccccat tcataaagtt aaatatagat ttacgaactt
    17941 cagaattagt caatccttcc aaattcacta taactgccct tctttgtttt agatggtctg
    18001 ctatagttgc agcttcatca taaaccttag gttcaactat tacaactttc atttggctag
    18061 ttgtatgtaa atttacaatt ttatttgctt ttgcagtact aaagccactg ttcatttctt
    18121 cttcttgaac tatatcgtcc atgccacttt catattcatc ttcaatgtaa tcttcttctt
    18181 catcaactat ccaattctta aatttagata ttattccatt tgacattatt aacttcctcc
    18241 ttaaaattta ttcaaatttg agtaattatt ttttattgta gtttctttct ccaaagattg
    18301 atgttccaac tctaacaatg gtagcccctt cctctatagc aatttcataa tcgtgactca
    18361 ttcccattga caaaacatcc atccctacat tagggatgtt tagttctttt atttgttttg
    18421 ataaatcttt aagaccttta aatacacctc ttatctcatc ttcatcttct ataaaaggtg
    18481 ccattgtcat tagacccttt atttttatat ttttatattt ttctgacact tctttgacaa
    18541 agtctacaac ttcttctcta tcaagtccat gcttagactc ttctttagat atattcactt
    18601 gtactaagca atctatttct ctgtttattt gttctgcacg tttttgaatt tcttcgcata
    18661 atgcaattct atctaaagag tgtatcatac aaactttatc gattatgtac ttaactttat
    18721 tggtttgcaa agttcctatc aggtgccagt ttaatttatc acctataata tcatactttc
    18781 tagctaattc ttggggttta ttttcaccaa cagaagtgat tccttccctc attgcctcat
    18841 taactaagtc tacatcaaca gtctttgtga ctgccaaaag ggtaatctct ttgctgtctc
    18901 tatctacttt ttttgcagct ttatcaattt tgtttcttat ctcagacaaa ttatctttaa
    18961 tagaacccat tattatcacc tactttatcc ttatatttgt gtttatactg ttaggtctta
    19021 aaattatttt gtcatataga ttaacacttg taactccatt tatgtcattt ttataataat
    19081 ccacaaatac agaagattca ttctcataag ttattccttc taatatgaca aattttacac
    19141 tttgtgattg ttcatcaatt acatatacac cacgtttatt gtcttttgtt tttatagaag
    19201 ttttaggtat ttttaaacat tccatctgat tatatattat atcaaattct tcgacacttg
    19261 tatcctgatt tgcaacaatt tggttactta tttttaattt taccattatt ttattattat
    19321 tttcatatat tttgtaaact tttgcatcta gtttttgctc atgatattca attattacat
    19381 tttgattttt ttcaaagtta ttagaatctt ctttactgat gtatgtagat agataattac
    19441 tttggtcatt ggcatctttt tctatagttc cttttacatg aatctttgca tcaacttttt
    19501 cattttttaa caccaacgta tctacatttt tgctaattat cattactaat atattaaata
    19561 ctaaatatat aagaatacca agtatcacta atctggtata ttttaccttt ttcaaagact
    19621 ctccccctat aaaattactt tcattataag tacttcttct aaaaaatgtt tattcctttt
    19681 ttataagata atattttacg ttctaataat tattttttcc atattaaatt tattttttat
    19741 caatcttcct atacaagact gcattattta tatataattg tattataaag tataagttta
    19801 atttacattt tatacgttaa gcttacttta tatattttta tagttatttt tatttttaga
    19861 tgcaatataa aaccaattaa gatttaaaat aacttttgtt atgttgacat ttatttaggt
    19921 aatcatttat gaattaggat aacgttatca caacaaaagt ttatgtccta aaaaaaatac
    19981 aaggaggatt ttcttatgtc agaaatttta ttaggaacag gtttactttt attggttcta
    20041 tgttgtttca caatttttag ttacaaggcc ccatatggta tgaaggctat gggagctcta
    20101 gcaaacgctg catgtgctac tttcttagta gaggcattca acctttcttt acttggtgat
    20161 gttttaggta tggaattttt tagaagtgtt ggagctgcta atggtagtct tggtggagtt
    20221 gctgctgcta tacttgtgcc tttagcctta ggtgtatctc cagtttatgc agttttaata
    20281 ggattatctt gtttagattt ttctatatta tctggattcg ttgctggata ctttgtttct
    20341 ttcttaatta agtttataga gaaaaaagtg ccacctggag tggatttagt ggttgtaatt
    20401 cttctatgtg caccactatc tcgtcttata gcatcaaatg tagacccatt agttaatagt
    20461 acactactac aaattgggca agttttgata gaagctacca acattagccc tataataatg
    20521 ggaattatac taggaggtct aataacagta gttggaacgt ctccacttag ttcaatggct
    20581 cttacatcta taattggtct tactggtctt cctatggcaa taggagcatt aggtgctttt
    20641 ggttcagctt ttatgaactc aacactattt gcaaaattga aattaggttc taaaaaagat
    20701 attatatctg ttgctattga accattaacc caatcagaca taatttcagc taatccaata
    20761 cctatatatt ctactaattt ctttggagga gccttttctg gtatcattgt agccttgatg
    20821 ggtcttgtaa acatgacacc aggtacagct acacctgtgg ctggttttgc tataatgttt
    20881 gcttataatc cagttcaaca agttcttata acagctggtt tatgtgcttt attcaatgta
    20941 attgcaggat ttttaggttc aaaaatattc agtaccttta aagttcttac tgctggtgaa
    21001 atacgtggta ctgatgtaga agaagaaatt gcttaaaaaa caataagatt tataaattta
    21061 tatctcaagt agtagagttt tatattgtag gcaattttat taattgcaaa cgttttattt
    21121 tttatttatg tttatgatta ttatgtgtgt tgaatattta gataaatttt tatttattat
    21181 ttttatttag atttttgttt agttttttat ttggttgata tattaggaat aaaaattagt
    21241 atagtttatt actagttaga tggcataact ttttagatac ataaaaaatt ttatattaat
    21301 tagatattat taaaataaaa gcgatacatg aatttttaaa tgtccatgta tcgctttatt
    21361 tttgccataa tcttaataac tgatttttaa agtttattat cttaacaaag ttcattatct
    21421 tatataatat ttaaatgcat aggcttcttt aatttaacca tctaaatatt taattaaata
    21481 ttattatatg taatataact aatttttaaa tgaatgtata ggagctggaa tccttcctcc
    21541 tctttgagta aataattcag atgaatttgt atttataggc attactggtg ctcgtcctaa
    21601 aagtcctcca aattctacca tatcacctac atcacatcct ggggctggta taattctaac
    21661 ggctgtagtc ttattattaa tcatacctat tgctgcctca tcagctatca tggctccaag
    21721 cgtacctgct gtagtatttc ctggcacagc tatcatatca agacctacag aacaaatagc
    21781 agtcattgct tcaagcttat ctatacttaa agcaccttta ataacagcat caatcatacc
    21841 tgcatcttca gatactggta taaacgctcc actaagtcct ccaacatgtg aacatgccat
    21901 tactccacct tttttaacag catcatttaa aagtgctaat gctgctgtag tcccatgagt
    21961 accaacaact tcaagaccca tttcctctaa tatatttgct actgaatcac caatagcagg
    22021 tgtaggagct agtgataagt ctattatccc aaatggaaca tccaatctac tagaagcttc
    22081 ctttgccaca agttgtccaa ctcttgtaat tttaaatgca gtctttttaa ctgtttctga
    22141 aacaacatca aaaggctctc cctttacttt ctctaaagct ctcttaacaa caccagggcc
    22201 acttacacca acatttataa ttctatcagc ctcaccaaca ccatggaaag ctcctgccat
    22261 aaatggatta tcttctactg cattacaaaa tactactaat tttgcacaac caaaaccttt
    22321 tgcatctttt gttaattctg cagtttcttt tatgatttct cccatttctt tcactgcatc
    22381 catatttata ccacatcttg tagaacctac atttactgaa gcacatactt tattagtact
    22441 tgctagagct tttggaattg acttaattag tatcttatca ccttttgtat atcccttttg
    22501 aactaatgct gagaatccac caataaaatc tatacctaaa tcctctgcag ccttatccaa
    22561 tgtctgtgca aactttacat agtcattttc atctgttgca cctgcaataa tggaaattgg
    22621 agttactgat acccttttat ttacaattgg gataccaaat tcacgctcta tatcttttcc
    22681 aaccttcacc aaatctttag cagaactcat aatcttattg tatatttttt ctctagcttt
    22741 atctccatca gggtctatac aatctaataa agaaatcccc atagttatag ttcttatatc
    22801 caactgttct tcatctatca tctttattgt ttcaagtata tttcctacat tcactattat
    22861 cacctcccct tactgtctac tacagattat gcattgaatt aaatatttct tctcgctgaa
    22921 tttttacatc cactgataat ttcttacctc tttcaaccaa gtcctcaacc gttttctcaa
    22981 aagaatttaa tgatttctct aaatcaacta tcataatcat agtaaaataa tcctgtaata
    23041 ttttttgtga tatatctact atgttgatat tttgcttgta taattcatca ctaattcctg
    23101 ccactatacc tggtttatcc tttccaatta ctgttaaaat tgctttcata ataatatcct
    23161 cccttatttt tttataaatc ttatattttt acaaattgaa ctatgtttta acatatattt
    23221 catttatttg ttagtaaacc a
//
LOCUS       DAEHWM010000065        23004 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.066, whole genome shotgun sequence.
ACCESSION   DAEHWM010000065 DAEHWM010000000
VERSION     DAEHWM010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 23004)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23004)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23004
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.066"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            383..1312
                     /gene="glsA"
                     /locus_tag="KNP36_002510"
     CDS             383..1312
                     /gene="glsA"
                     /locus_tag="KNP36_002510"
                     /EC_number="3.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaminase A"
                     /protein_id="HBF0874371.1"
                     /translation="MNTLDETLLKEIISSNKKYTNYGQVASYIPELKNARRNDLGICI
                     IDSENNLYSAGNCSTKFTIQSISKPIVLAMALMDNDWEDVFSNVGMEPSGDPFNSIMK
                     LEINDTKKPCNPMINAGAIVTTSLINGSCLEEKEERMLSFFRKLAKNDNIGINYDVYK
                     SEKMTGDRNRAMAYLLKSDGFIRGNVEDVLDLYFKQCSIEIDSVDLARIGINLANYGV
                     DIENGEHLMSEMVSRIVKTFMMTCGMYDASGEFAIKVGIPAKSGVGGGIMASVPGRMG
                     IGVYGPALDKKGNSVAGVKVLEELSNKLKLNIF"
     gene            1410..1973
                     /locus_tag="KNP36_002511"
     CDS             1410..1973
                     /locus_tag="KNP36_002511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874372.1"
                     /translation="MKEVLVLRDLECIKAIAHPRRIDILKAFDKSPLSAKQLSQLLEE
                     PHAKINYHIKMLYKVGILELVEEKIKSGIVEKYYYPSAKNVVIGNRILNFSLDNGEEK
                     EELYISKFENMSEVFYKAAEEDVLENENIVDYHDISLTHDELVELSDTMKSKIDEILN
                     KRQHNVEGSKYDIAMVIVPTLEEECPS"
     gene            2461..3297
                     /locus_tag="KNP36_002512"
     CDS             2461..3297
                     /locus_tag="KNP36_002512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribonuclease IV"
                     /protein_id="HBF0874373.1"
                     /translation="MIKLGTHLSIAKGFANAAETAVYIGANTFQFFSRNPRGGNAKEF
                     DEKDIIKFQEIRKENNFAPLLAHAPYTMNLGGTKDDVYEFATRVIDEDIRRMDSLGIE
                     YMCFHPGSHVGGGVDFGIDRIVKGLNNAIKGDENITILLETMSGKGTEIGFKFEQLKS
                     IIDKIEHKEKIGVCLDTCHIFSAGYDIVNDLDGVLEEFDKVIGIERLKTVHLNDSMMP
                     FGDKKDRHAPIGEGKIGLKALIDFMEHPSLKHLPFFLETPFDDEGHKRELKMIKEILS
                     SK"
     gene            3581..4576
                     /locus_tag="KNP36_002513"
     CDS             3581..4576
                     /locus_tag="KNP36_002513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBF0874374.1"
                     /translation="MRNLGNTNMKIKRVGFGGIPIQRITQDDTNLVINELEKQGINFI
                     DSARGYTISEEAIGIAIEGKRDKFFLATKSMSRDYDSMKRDVEISLNNFKTDFIDLYQ
                     FHNVKEEEYDNLFKDKMAYSALLEAKEQGKIKHIGITSHNLNTIEKAIEDGKFDTIQF
                     PYNIVEGQADEVFKKAHEKGIGIIVMKPLAGGALDNATLAIKYILSKEYIDVVIPGME
                     SVEQVRQNVAVLENLVLDEKDNKEIEEIRNSLGKKFCRRCEYCMPCAVGINIPLSFLC
                     EGYYTRYGLKEWAKEKYEVMDVKPTECIDCGLCESRCPYELPIREMLKTVVEKLG"
     gene            complement(4833..5237)
                     /locus_tag="KNP36_002514"
     CDS             complement(4833..5237)
                     /locus_tag="KNP36_002514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RusA family crossover junction
                     endodeoxyribonuclease"
                     /protein_id="HBF0874375.1"
                     /translation="MIKITIPGRPISKSNFKLHNINGQAWMPSKGKYSKYLAYENMIA
                     GFINQQYQGETVEENLITVLKLFFPNKRMGDLHNYPKSICDGIEKSGIIKNDKQLKPV
                     LLFDFIDKDNPRVEIELYPVSKYDISYNIFEK"
     gene            6259..7173
                     /gene="queG"
                     /locus_tag="KNP36_002515"
     CDS             6259..7173
                     /gene="queG"
                     /locus_tag="KNP36_002515"
                     /EC_number="1.17.99.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA epoxyqueuosine(34) reductase QueG"
                     /protein_id="HBF0874376.1"
                     /translation="MDNKELKAFCNLIGLNCVGVAGVDKYDNLEKILKDRQQKGYLTG
                     MEEPIIENRINPRHIMKDANSIIVCAFPYHINRQEKNKNSNLSKYCHGKDYHIVVKDF
                     LQQICDYISKTVTDFKYKLFADNGPLVDRYLAYLSGIGYFGINNNIITDEYGSYVFIG
                     YIVNNYKFEEDKPLEKSCFKCGKCVKYCPGNAILGNYDMNPKKCLSYITQKKGDLSEK
                     EKVVLKNGKKVFGCDICQEVCPHNVEIPTTHILEFKENIIDYLNYDEIQNISNKEFKR
                     KYGDRAFSWRGRNIIKRNMEIILDKYDD"
     gene            7279..9516
                     /locus_tag="KNP36_002516"
     CDS             7279..9516
                     /locus_tag="KNP36_002516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0874377.1"
                     /translation="MKYNNTSEINPLDYILGQERAVEAMELGLKINNPAYNIYIAGEP
                     GTGKSTYALKVLNEYASKKNTHKDWCYIYNFENPREPIIVELEKGFGRELKKDMEKLI
                     ESLLEDFKNAFESENFEIEKNKLLDEYEIEKDMLLKQIKKYGEEKGFKLKQSKMGIVF
                     IPLKEEEDESDESDEEFYKAKRELENMAIQVVYKIRNLEEIAEKAVLELEEEIAKLVV
                     EPHIKRLCEKYENYDKIQTYLENIKKDIIEYMYLFYLDEEELKDKYDKEHFIKYKINL
                     FVDNGSSKNKESAPVVVEINPSPANLFGKAEYDYANGNIKTDFTKLLSGAFHRANGGY
                     LVLYADQLLKYTMSWEILKKTLQTKKVILETQTAIKPENMPLDVKLVLIGSHYIYDIL
                     YRYDEDFEKYFKVFVDFDSEMDKNEDNEEGIARFIAYQCDKNNLRHFTKSAVEEVIKF
                     STRLSGDLEKLSTKFNKIMEVVIEGSAYAEFRNSEYTEQCDVKKAISEKRKRINRVET
                     HMDESIENGFTLIETEGRKVGVINGLSVLSTGEYSFGRASRITATTSPGSKGIVNIER
                     EVNMSGSIHNKGVLILGGYLSENFAQDLLLSLNAYVCFEQNYGGIDGDSASSAELYVL
                     LSSLSGVSIKQNIAVTGSINQKGDIQVVGGISEKIEGFYSICKTKGLNGEQGVIIPRK
                     NQRNLVLSDEVNDAVRDGKFKIYTVERVEEAIEILTDVKFEEIKKLVKEKLISFSKIQ
                     TVSKE"
     gene            9714..10883
                     /gene="nth"
                     /locus_tag="KNP36_002517"
     CDS             9714..10883
                     /gene="nth"
                     /locus_tag="KNP36_002517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HBF0874378.1"
                     /translation="MKNVNLKEINEKDVILEEEINKKGMDKKNIIEKEEINKKGIDKK
                     DIIEKEEINKKGIDKKDIIEKEEINKKGMNKKDIIEKEEINKKGMNKKDIIEKEEINE
                     KGIDKMIGKKDEIIDEKDIENFMDIEEDKKSIKVSKKSTKKGETEKKTKKSSSNKATQ
                     KTSKETKSKSKIKNESANEKDVNKILDELEKLYPDAKCELNYGTAFELLIATILSAQC
                     TDVRVNKVTSELFKKYNTARDFANLSIEEISKEIKSCGLYKSKSQKIKDTSEQLCELY
                     DGEVPDSLEKLIKLPGVGRKTAGVVLSNAFNHPAIAVDTHVFRVSNRIGIVDEPNPQK
                     TEFALMEAIPKERWSHSHHVLIFHGRRMCKARNPECASCPIKEDCNYYKELNETK"
     gene            11077..11547
                     /gene="trmL"
                     /locus_tag="KNP36_002518"
     CDS             11077..11547
                     /gene="trmL"
                     /locus_tag="KNP36_002518"
                     /EC_number="2.1.1.207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (uridine(34)/cytosine(34)/5-
                     carboxymethylaminomethyluridine(34)-2'-O)-
                     methyltransferase TrmL"
                     /protein_id="HBF0874379.1"
                     /translation="MSLNIVLVEPEIPQNTGNIIRTCAATGSTLHLVKPLGFSLDDKH
                     LKRCGLDYWDIADIQYYDSFEELQEKYPNSKYFFSTTKAKQSHSDVKYEENCFIVFGK
                     ETKGLPEPLLKANMDTCIRVPMLDVEKARSLNLSNSVAIVVYEALRQIGYPNMR"
     gene            11583..12431
                     /locus_tag="KNP36_002519"
     CDS             11583..12431
                     /locus_tag="KNP36_002519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HBF0874380.1"
                     /translation="MKNLKIICDSLSDVPKDLLDKYDIDIVSLTVILEEREYKDRIDI
                     SGDEFYKRLREENVYPKTSQATYAQFKEIFEKYTNEDREILYIAGSATATGTYQSAVM
                     AKNDVDGKIYTYDSNLLCMGTGLLVIKAGELASEGKSVAEILPVLDELKEKAFVIFSV
                     DTLEYLQKGGRISSTKAAIGSILNIKPILEIRDGLVSQISQVRGKKNVISKMMELIKS
                     NCGDDLSDQIVYIGYSDDFKEKEQLSKVMQDELRPKEIRFFQIGVCIGAHAGPGVTGI
                     ICLKNK"
     gene            12719..13723
                     /locus_tag="KNP36_002520"
     CDS             12719..13723
                     /locus_tag="KNP36_002520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0874381.1"
                     /translation="MRFKRILILMLTVAMIAGMLVGCANNPSNNPSSSKDNKSDISDK
                     SNSKKSVSMILDIEGTNNEAMNNSALLALNNAQKKLNIDTNKVESDDSSTFSNSIDIL
                     CNDNYDLIIAVGARFAKPLEMVAKKYPKQQFAIIDYEYDKQPSNITSISYEDNKSGYL
                     AGLIAGKMTESDKVGFIGGTKSSSRDKFESGFREGVKFSNSSIKDISVEYADVFKDSK
                     SVESIAKKMMDNGVDIIFSTTEDDSKAVIDAVRAKNKKVIATNKDQHELAPENVISSI
                     VKDFENPTYNLIQSFVKGNYKGGKVIENTVKSGSTGLAQNSSQNIPPDVLEYVNKNNK
                     "
     gene            13849..14961
                     /locus_tag="KNP36_002521"
     CDS             13849..14961
                     /locus_tag="KNP36_002521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0874382.1"
                     /translation="MKIKRILMACFVVVFTIFILAICNFDFGFDKVNKNNSNIDSAKS
                     KQSESKSLLTSAEKDKSNSKSKNKEDDTEDDSYVRKTIGVLLDTENLNNESYNNNVLS
                     ALKRADEDFDVRIKLEKPKTSKSFKESIEKLHKYEPDFIIAVGARFAEPIKEAATKYP
                     KQQFAIVDYTYKVQPANVISVSFQDNVTGYLAGLIAGKMTDTGKVGFIGGVEGSSRDK
                     YESGFRKGLKTSNKDAELLVKYSNIFENPESARTIAKEMRDSDRDVVFSATEDDSKRA
                     IQVARENGGKVIAINKDQYDMAPDNVISSIIKDVEQPVYELIKNVAKDGFKGSKVMEF
                     KIKDGELGLTSKSSRNIPPDVLEYIKKEYNKVKDTY"
     gene            15451..16212
                     /locus_tag="KNP36_002522"
     CDS             15451..16212
                     /locus_tag="KNP36_002522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417991.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874383.1"
                     /translation="MEFTREPFILDDDLCLALVDKRISYLMENELKLRNIEIIKTIEC
                     KELYESIKYHPDICICNLGKGDIIVAPNVYNQYKELLSRYKFNIIKGEANLLNRYPYD
                     IPYNIAIVGDYAIHNFKYTDKAILDYIENNKLKKINIEQGYSKCSICIVDRTSIITSD
                     KGIWKSMKNTEIECLLIEKGHINLFEMNYGFIGGCTGLISKDKLAFCGDVKKHPDYER
                     IKSFVESKNKEIVTLSCENLLDIGSIVPLMTRKER"
     gene            16215..17033
                     /locus_tag="KNP36_002523"
     CDS             16215..17033
                     /locus_tag="KNP36_002523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative sporulation protein YtxC"
                     /protein_id="HBF0874384.1"
                     /translation="MVEKDNISSMKFLRNNNVNDRLIYTNDIVEVVIDSAKQEVLNKK
                     ILNGTKAEQRALNIDEISTEITSMIISIMKEKLLKEYILKCYGRTYPEDKNNIYIYSL
                     NIFAKKEIFMRETVFTRVRNYIEENDFINVEGFIRFRMREFMKYISAIGDIAVEEYLI
                     KKDQDEFIRVLKYFIDTQEEKIDLLKVHIMEDNTFVLYDKNGNKIDSIDDEEIINMVI
                     RENLNYEDFLISTLLTLCPKKIEILDLLNNNCSKEIIDTVEAIFENKVSIIMEN"
     gene            17213..17815
                     /locus_tag="KNP36_002524"
     CDS             17213..17815
                     /locus_tag="KNP36_002524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF445 family protein"
                     /protein_id="HBF0874385.1"
                     /translation="MDNLIRILILAVIGGFIGYVTNVVAIRLIFRPIEPIKIPILNIE
                     IVGLIPKRRAEIAANVGEIIQEEFLSMDEILANIITDEDKEEVVRYIKARVKIIIHEK
                     VSFIPSGIKNMIQDYLGEIIESEVKQSIDELSKNIINKANERIDIQKMVEDKINELDL
                     YELEEIIIRIAKKELKHIEFLGLVLGFLIGIAQGLITMFI"
     misc_binding    18427..18665
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            18729..20648
                     /gene="thrS"
                     /locus_tag="KNP36_002525"
     CDS             18729..20648
                     /gene="thrS"
                     /locus_tag="KNP36_002525"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HBF0874386.1"
                     /translation="MIKVALKDGSIKEFENAISVMDVAKSISEGLARNVVAASVNGEV
                     VGLDHIIDTDCDLNLFKFEDKEGKEVFRHTSAHILAQAIKRLYPEAKLAIGPSIENGF
                     YYDIDLDHRLVPEDLEKIEAEMKKIAKEDLKIERFELPRNEALELMKEQGEDYKVELI
                     SDLPESEIISFYKQGDFTDLCRGPHLPSTKKVKAVKLQSVAGAYWRGDENNKMLQRIY
                     GTSFEKNKDLEEYLHLLEEAKKRDHRKLGKELGLFMIPEEGPGFPMFLPKGMELKNEL
                     LKFWREIHRKAGYIEIESPIILNRKLWETSGHWYHYKENMYTVKIDDEDYAIKPMNCP
                     GGLIYYNSQLHSYRDFPMRVAELGRVHRHELSGALQGLMRVRAFTQDDSHIFMLPEQI
                     KDEIKGVANLIDGIYKTFGFEYNLELSTRPENSMGSDEEWEAAENGLREALEELGLPY
                     TINEGDGAFYGPKIDFHLKDCLGRTWQCGTIQLDMQLPRQFDNTYIGQDGEKHRPVMI
                     HRVAFGSIERFIGILIEHYAGKFPVWLSPTQVKILPISDKFMDYANEVKKELFDKGIR
                     VELDDRAEKIGFKIREAQLEKVPYMLIVGEKEVADNNVSVRSRDKGEIGSIKLDEFIA
                     SISKEIESRESIIQD"
     gene            21416..22507
                     /locus_tag="KNP36_002526"
     CDS             21416..22507
                     /locus_tag="KNP36_002526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBF0874387.1"
                     /translation="MIEKVEEKSKIIKTSKEYKRTIIEEKDKEWTKKLNDILSRSSFS
                     NDELDKIKALIPKEILTNENVGEVVTEDGYAKPEYDEVFKSLFTLNNEYDLLVNFIND
                     ILKDAPYANRNIKPFTQIKRIIRVETDPTINYIGEKRPKLDILAEDEENNHINIEMQR
                     AFENDYLERAEYYLSRVHGRKLEEGKEYKEIGKTIGIHILNHVKYNHIEDYVNCLRLT
                     MDGHPDIYSSKTALYFIELPKIHKSDYIVNRIMLWGKLISNPSNLDVRVIAKNDSIIK
                     KALDRLKELGSNEEYLLNLKRGAYIMNKSRNFKEEIERETAIRVAKEKDYKIIIMLKK
                     NGFKLDDILNKFNDFDLSEDEIKEVYENN"
BASE COUNT         9414 a         2102 c         4177 g         7311 t
ORIGIN      
        1 ttgttgaatt actaaattac taggttgtta agttactgga ttattagata gttagattac
       61 taggttgtta aattgttaaa ttattgaatt gttagattgt tgaattacta aattactagg
      121 ttgttaagtt actggattat tagatagtta gattattaga ttgctaaatt attaggttgt
      181 taaattactg gattattaga ttactaaatt gctaggttgt taaattatta aattattaag
      241 ctatttaaac tatttaaatt gtttgaaaaa tgaattgatt cttgtagaaa ataattttaa
      301 agtataattt tttttaacat tgttttatta tagtataaac ttgtgctaaa atagaatata
      361 taacataata taagaggtgc atatgaatac gttagatgag acattattaa aagaaattat
      421 aagttctaat aagaagtata ctaattatgg acaagtcgct agttacatac cagaattaaa
      481 aaacgctaga agaaatgatt taggaatttg tatcatagat agcgaaaata atctttatag
      541 tgctggaaac tgtagcacaa agtttactat acaaagtatt tcaaaaccaa ttgtgcttgc
      601 tatggcactt atggataatg attgggaaga cgttttttca aacgttggaa tggagccaag
      661 tggggaccca tttaattcaa taatgaaact tgaaattaat gacacaaaaa aaccctgtaa
      721 tccaatgata aatgcagggg ctatagtaac cacttccctt ataaatggga gttgtttaga
      781 agaaaaagaa gaaagaatgc ttagtttctt tagaaagtta gcaaaaaatg ataatatagg
      841 aataaactat gatgtctata agtctgaaaa aatgactgga gatagaaaca gagctatggc
      901 ttacttattg aaaagtgatg gatttatcag agggaatgta gaagatgttc tagaccttta
      961 ttttaaacaa tgctcaattg agatagattc tgtagattta gcgagaattg gaataaatct
     1021 tgcaaattat ggagtagata tagaaaatgg tgagcattta atgagtgaaa tggtttctag
     1081 gattgtcaag acatttatga tgacttgtgg aatgtatgat gcttctgggg aatttgctat
     1141 taaagttggc attcctgcaa aatctggagt tgggggtggt ataatggctt ctgtgccggg
     1201 acgcatgggg attggtgttt atggacctgc gcttgacaaa aaaggtaaca gcgtcgcagg
     1261 agttaaagtt ttagaggagt tgtcaaataa actcaaatta aatatttttt aaaatattaa
     1321 gaaaggattt ttttgacaac aacatataat ttaatatata attaaattgt aaagaaatat
     1381 gaattaaata aattttttag gaggggtcaa tgaaagaggt attggtatta cgagatttgg
     1441 agtgcataaa ggctattgcg catccacgta gaatagatat tctaaaagca tttgacaaat
     1501 cgccattgtc agcaaaacaa ttatctcaat tattggaaga acctcatgca aaaataaact
     1561 accatataaa aatgttatac aaagttggta ttttagaatt agttgaggaa aaaataaagt
     1621 cggggattgt ggaaaagtac tattatccaa gtgcaaaaaa tgtggttata gggaatagga
     1681 tacttaattt ttctttagac aatggggaag aaaaagaaga attgtacata tcaaaatttg
     1741 aaaatatgag tgaagttttt tataaggcag cagaggaaga tgttttagaa aatgaaaata
     1801 tagttgatta tcatgatatt tctcttactc atgatgaatt agttgaactt agtgacacta
     1861 tgaagtcaaa gatagatgaa attttaaata aaagacaaca caatgttgaa ggttctaagt
     1921 atgatatagc tatggttata gttcctactc ttgaggagga atgtcctagt tagagaatta
     1981 attatggatt aattaaagat ataatattag agattgaaca tcaaaattta cttaataatc
     2041 aaaaaatagt ttttggtatg ggtaaaacaa tgatttttaa tctctatttt tttgtttttt
     2101 tatacctatt gtatttgtaa ataatatgta tagtgtaaga tgtatacact atctaagaag
     2161 tgcttagata atatacaaag tatgtaagat tataatattt gaaattgatt aaaatgggta
     2221 taattaaagt gtaaatatta aaattaaaaa ttaatataaa ttaaatcaat gctagaaata
     2281 tgttaaaaga ggaatgagat tagttgggat agaacatccc ttagagctta cgaattttta
     2341 gtgaaaaagt actatcaaat aggaatctcc atcttcatat gttggctaaa tgtagttaag
     2401 gtggagtagt tcaaaattaa aattgagtac aagtagtagt acaaataaaa ggagattaat
     2461 atgattaaat taggaacaca tctttcaata gcaaaaggat ttgctaatgc ggctgagaca
     2521 gctgtatata ttggtgcaaa tacatttcaa ttttttagta gaaatccaag aggaggaaat
     2581 gctaaagaat ttgatgaaaa agatataatt aaatttcaag aaattagaaa agaaaataat
     2641 tttgcaccac tgcttgcaca tgcaccatat actatgaatc tgggtggtac aaaggatgat
     2701 gtatacgaat ttgcaacaag ggtgatagat gaggatataa gaaggatgga ctcattagga
     2761 attgaataca tgtgttttca tcctggaagt catgtaggtg gtggtgtaga ttttggcata
     2821 gatagaatag taaaaggatt gaacaatgcc ataaagggtg atgaaaatat aactatactt
     2881 cttgaaacta tgtcgggaaa gggaactgaa ataggtttta aatttgagca attaaaaagt
     2941 ataatagaca aaattgagca taaagaaaaa ataggtgtgt gtcttgatac atgtcatatt
     3001 ttttcagctg gttatgatat agtgaatgat ttagatgggg ttttggaaga atttgataag
     3061 gttataggca tagaaagatt gaaaactgtc catctaaatg atagtatgat gccatttgga
     3121 gacaaaaaag acagacatgc tcctataggg gaaggaaaga taggattaaa agcattaatt
     3181 gattttatgg aacatcctag tctaaaacat ttaccatttt tcttagaaac tccttttgat
     3241 gatgaaggtc acaagagaga gcttaaaatg ataaaagaaa tactatctag taaataaacc
     3301 tttattaaaa atatgtgaaa tactccaccc tcaacataat tagggtggag atacaatcat
     3361 gaaatgtgat aatttaaatt aatggatagg aataacgaaa attgtataca aattaactgg
     3421 gtataaagta tgattatatt atgaatagac tgatataaaa tataattata ttatgaatag
     3481 tatgtaaata cattgcaaag attctcataa tttgttgtat aattaaaggt gacatattta
     3541 tattatataa aaaattatta aaagttaggt ggggaaagat atgagaaatt taggcaatac
     3601 taacatgaaa ataaagagag ttggctttgg gggcattcca atacaaagga ttactcaaga
     3661 tgatactaac ttagttataa atgagttaga aaaacaagga ataaacttta ttgacagtgc
     3721 aagagggtat acaataagtg aggaagcaat cggaattgcc attgaaggaa aaagagataa
     3781 atttttctta gctactaaaa gtatgtccag agattatgat tcaatgaaga gagatgttga
     3841 aataagttta aataatttta aaactgattt tatagattta tatcaattcc ataatgttaa
     3901 agaagaggag tatgataatc tttttaaaga taaaatggct tatagtgccc ttttagaggc
     3961 aaaggagcaa ggtaagataa aacatattgg tataactagt cacaatttaa atactataga
     4021 aaaagctata gaagatggaa aatttgacac tatacaattc ccttataata tagttgaagg
     4081 acaagcagat gaagtgttta aaaaagctca tgaaaaagga attgggataa tagtaatgaa
     4141 acctttagct ggaggtgctt tagacaatgc aacactggct attaaatata tactatctaa
     4201 agagtacata gatgtagtta taccaggtat ggagagtgtt gaacaggtta gacaaaatgt
     4261 cgctgtactt gaaaatcttg tgctagatga aaaagataat aaggaaattg aagaaataag
     4321 aaattcttta ggtaaaaaat tctgtagaag atgcgaatat tgtatgcctt gtgctgtagg
     4381 aataaatata ccattgagtt ttttatgtga aggttattat actagatatg gattaaaaga
     4441 gtgggctaaa gaaaaatatg aggttatgga tgttaaacct actgagtgta ttgactgtgg
     4501 gctttgcgag agtagatgtc catatgaact tcctataaga gaaatgctta agactgttgt
     4561 tgaaaagcta ggatagattt tatttattga aatcggtgta ttaaatttac tccgatttct
     4621 ttttattaga tgtggtctta tatacaaata ttaaatttac atagttatag ctattatata
     4681 aatttaatat ttgtttaata cttattaaat atttacttaa tgctttttaa aaacatttgt
     4741 ttgagtatag acataacaca attattattg ttgtattagt atagtttcaa atactggagt
     4801 atcaatataa tgtcgaataa cacataaaat ctttattttt caaaaatatt ataggatata
     4861 tcgtatttag atactggata aagttcaatt tcaaccctag ggttatcttt atctataaaa
     4921 tcaaataaaa gtactggctt aagttgttta tcatttttta ttattccact tttttcaata
     4981 ccatcacaaa tactttttgg ataattatgt aaatccccca ttctcttatt tgggaagaat
     5041 aatttcaaga ctgttattag attttcttcg acagtttccc cttgatactg ttggtttata
     5101 aaacctgcaa tcatgttttc gtatgcaaga tacttagaat attttccctt tgaaggcatc
     5161 catgcttgac catttatgtt atgaagctta aaattagatt tactaatagg tctacctgga
     5221 attgttattt taatcaaatt tttcaccatc cttatacagt atttattata atctgtatat
     5281 gatttaaaag caaattgtta tttaaagtgt ttttacagag cttttttgta aaattttcca
     5341 ctttagatgt agtaatataa gataagtatt ttgcttacaa attttaaaat ttgatatatg
     5401 atggacatat tcatattagt ctattataag accttcataa tattaataag tatagtttag
     5461 taaagagagt aaaaagaaat ccatataagt caagtaaaga tttaataaat ggcaatgtaa
     5521 atgggatatt aattataaga aaaaatcaat ctttttgctt aactatagaa agaatgtcaa
     5581 aatataacta atgatatttg aagttttaga gtttatatta aaaggtaaga aggttaagtg
     5641 ggtaaaaaag gttgaataga ttaaaaaggc taagtatcta aaagagttaa gtaggtaaaa
     5701 aagttaaata agtaaatgaa aaaggctaag tatctaaaag agttagtagt taaataagta
     5761 aatgaaaaag gctaagtata taaaggagtt agtagataaa aaaattaaat agataaaaag
     5821 attaagtatc taaaagcgtt agtagataaa aaaattaaat aaataaaaaa gactaagtat
     5881 tcaaaagagt tagtaggtaa aataattaaa tagataaaaa gactaattat ttaaaggagt
     5941 taagtagata aaaaagttaa ataagtaaat gaaaaagacg aagtatctaa aagagttagt
     6001 aaataaaaaa gatgaagtat ctaaaagagt tagtaggtaa aaaactaaat agataaaaag
     6061 attaagtatc taaaagcgtt agtaggtaaa aaattaaata ggtaaaaaga cgaagtatct
     6121 aaaagattta agtaggtaag aaaattgaat agctaaaaag attaagtatt taaaagagtt
     6181 agtagctaga aaaggttaaa aagactaaaa aaattaaata aatttaaaaa gtcaattaga
     6241 ttaaaaagga ataattttat ggataataag gaattaaaag cattttgtaa tttaatagga
     6301 ttaaactgtg taggagtagc aggggtagat aagtatgata atttagaaaa gatacttaag
     6361 gacagacaac aaaaaggtta tttaactggt atggaagaac caataattga gaacagaatt
     6421 aacccaagac atataatgaa ggatgctaac tctataatag tctgtgcatt tccatatcat
     6481 ataaatagac aagaaaagaa taaaaattca aatttatcaa aatattgtca tggaaaggat
     6541 tatcacattg tagtaaagga ctttttacaa caaatttgtg attatatttc taaaacagta
     6601 acagatttta aatacaagtt atttgctgat aatggaccat tagttgacag gtatttagct
     6661 tatttatcag gaataggata ttttggaata aataataata tcataactga tgaatatggt
     6721 tcttacgtat ttatagggta tatagtaaat aattataaat ttgaagaaga taaaccacta
     6781 gaaaaaagtt gttttaaatg tggaaagtgt gtaaaatatt gtccgggaaa tgctatattg
     6841 ggaaattatg atatgaaccc caaaaaatgt ttatcatata taactcaaaa aaaaggagat
     6901 ttgtcagaga aagaaaaagt tgttttaaag aatggcaaaa aggtatttgg atgcgatatt
     6961 tgtcaagaag tatgtccaca taatgttgaa ataccaacaa ctcatatttt ggaatttaaa
     7021 gaaaatataa tagattattt gaattatgat gagatacaaa atatttcaaa taaagaattt
     7081 aaaaggaaat atggagatag agcttttagc tggagaggaa gaaatataat aaagagaaat
     7141 atggaaataa ttttagataa gtatgatgac taataataag agtctgtttc atatacttta
     7201 atgtgtattt actttaacac ttgttgtgta aaagtcatat tatatcatta aagttaaata
     7261 tggggaggtg ggggaatatt gaaatataat aatacatctg aaataaatcc actagattat
     7321 atattgggtc aagaaagagc tgtagaagct atggaattag ggttgaaaat aaataatcca
     7381 gcgtacaaca tatatatagc tggtgaacct ggaactggta aaagtactta tgccttaaag
     7441 gttttaaatg agtatgcatc caaaaaaaat acgcataaag attggtgtta tatatataat
     7501 tttgaaaacc ctagagagcc tattatagtt gaattagaaa aggggtttgg aagagaactt
     7561 aagaaagata tggagaaatt aattgaaagt cttttagaag attttaaaaa tgcgtttgaa
     7621 agtgaaaatt ttgaaataga aaaaaataaa cttctggatg aatatgaaat agaaaaagat
     7681 atgcttttga agcaaattaa aaaatatgga gaagaaaaag gatttaaatt aaaacagagt
     7741 aaaatgggaa tagtttttat ccctttgaaa gaagaggaag atgaaagtga tgagtctgat
     7801 gaagagtttt acaaagctaa aagagaacta gaaaatatgg cgatacaggt cgtatataaa
     7861 attagaaact tagaagaaat agctgaaaaa gcagtgttag agcttgaaga agagatagct
     7921 aaacttgtag tagaacctca tatcaagaga ttgtgtgaaa aatatgaaaa ttatgataag
     7981 attcaaactt atctggaaaa tataaagaaa gatataatag aatatatgta tttattctat
     8041 ttagatgaag aggagttaaa agataagtat gataaagagc attttattaa atataaaatt
     8101 aacctatttg tagacaatgg aagctcaaag aataaagaat cagcacctgt tgtagtagag
     8161 ataaacccaa gtccagcaaa tctatttgga aaggcagagt atgattatgc aaatggaaat
     8221 ataaagactg atttcacaaa actattatca ggagcatttc atagggctaa tggtggttat
     8281 ttagtacttt atgcagacca attactaaaa tatacaatgt cttgggaaat tcttaaaaag
     8341 actttgcaga ctaaaaaagt aatattggaa acacaaacag caattaaacc agaaaatatg
     8401 ccattggatg ttaaattagt actgattgga agccactata tatatgatat tttatataga
     8461 tatgatgaag attttgaaaa atattttaaa gtatttgtag actttgatag tgaaatggat
     8521 aaaaatgaag ataatgaaga aggaatagca agatttatag cataccaatg tgataagaat
     8581 aatttaaggc attttactaa atcagcagtt gaagaggtta ttaaatttag cactagatta
     8641 tctggtgatt tagaaaaatt atcaactaag tttaataaaa taatggaagt tgtaatagaa
     8701 ggaagtgctt atgcagagtt tagaaattcg gagtatacag agcagtgtga tgttaaaaaa
     8761 gcaataagtg aaaagagaaa aagaatcaat agagtggaaa cacatatgga tgaatcaatt
     8821 gaaaatggat ttactctaat agaaacagag ggaagaaaag taggagtgat aaatggtttg
     8881 tcagtcttaa gtacaggaga atactctttt ggtagagctt caaggattac agcgaccact
     8941 agcccaggaa gtaaaggcat agtaaatata gaaagagaag taaatatgag tggctctata
     9001 cataacaaag gagtacttat attaggtggc tatctttctg agaattttgc acaggattta
     9061 ctattgtcac taaatgcata tgtttgtttt gaacaaaatt atggtggaat agatggagat
     9121 agtgcatctt ctgcagaatt atatgtacta ttatcatctc ttagtggagt atcaattaaa
     9181 caaaatattg ctgttacagg ttctataaat caaaagggtg atatacaagt agttggtggt
     9241 ataagtgaaa agatagaagg attttattct atatgtaaaa ctaaagggtt aaatggtgag
     9301 caaggcgtca taattcctag aaaaaatcaa agaaatctcg ttttatcaga tgaagttaat
     9361 gatgcagtgc gagatggaaa atttaagata tatactgttg aaagagtaga agaggctata
     9421 gagatattga cagatgttaa atttgaagaa ataaagaaat tggtaaaaga aaaattaata
     9481 tctttcagca agatacaaac tgtgtcaaaa gaataagttt attatagaat ttaatgggta
     9541 tttatgtata ataaaaagca agaactttaa taggtttttg ctttttttgt aaatatatat
     9601 aaattaaatt cttattttgt atgttttata tattgatgtt tatttttttg ttgatatgat
     9661 taaactattt ataaatagcg ttttataaat tggtattttg aagggggata attatgaaaa
     9721 atgtaaatct aaaagagata aatgaaaaag atgtaatttt ggaagaagag ataaataaaa
     9781 aaggaatgga taagaaaaat ataattgaga aggaagagat aaataaaaaa ggaatagata
     9841 agaaagatat aattgagaag gaagagataa ataaaaaagg aatagataag aaagatataa
     9901 ttgagaagga agagataaat aaaaaaggaa tgaataagaa agatataatt gagaaggaag
     9961 agataaataa aaaaggaatg aataagaaag atataattga gaaggaagag ataaatgaaa
    10021 aaggaataga taaaatgatt ggtaaaaaag atgagataat tgatgagaaa gatatagaga
    10081 attttatgga tattgaagaa gataaaaaaa gtatcaaagt aagtaaaaaa agtactaaaa
    10141 aaggtgaaac ggagaaaaaa acaaagaaga gtagttctaa taaggctaca caaaaaacaa
    10201 gtaaagaaac taaaagtaag tctaaaatta aaaatgagtc agcaaatgaa aaagacgtaa
    10261 ataagatttt agacgagtta gaaaaattgt atccagatgc taaatgtgag ttaaattatg
    10321 ggacagcctt tgaactttta atagcaacta ttttatcagc acaatgtact gatgtaagag
    10381 tgaataaagt tacttcagag ttgtttaaaa agtacaacac agctagagac tttgctaatt
    10441 tgagcattga agaaattagt aaagagataa agagttgtgg tctttacaaa agcaagtctc
    10501 aaaaaataaa ggatacatct gaacagctat gtgaattata tgatggtgaa gtacctgata
    10561 gcttagaaaa gcttataaaa ttacctggtg ttggaagaaa aacggcaggg gttgtactta
    10621 gtaacgcttt taatcatcca gcaatagctg tagatactca tgtatttaga gttagcaata
    10681 gaataggaat agtggacgag ccaaatcctc aaaaaacaga atttgcactt atggaagcta
    10741 taccaaaaga aagatggtca cactcacatc atgtattaat ttttcatgga agaagaatgt
    10801 gtaaagctag aaatccagaa tgtgcaagtt gcccaataaa agaagattgt aattattata
    10861 aagaacttaa tgaaacgaaa taacttttag aaagtaagtt gtacaagagg gattttctga
    10921 tataataata cttgtgaaaa tgttagataa aaaactatta tatacatgaa ataaaaatta
    10981 ttattaacat tattttatat aatagtataa tattattgtt attctgttta taaaataaaa
    11041 tttgataaat aaaagcgata cttagggagg attaaaatgt cattaaatat agtattagta
    11101 gaaccagaaa tacctcaaaa tacaggaaat ataataagaa cctgtgcagc aacaggttca
    11161 actttacatt tagtaaaacc actgggtttt tcattggatg ataaacacct aaaaagatgt
    11221 gggcttgact attgggatat agctgatata caatattacg atagctttga agaattacaa
    11281 gaaaagtatc caaatagtaa atactttttt tctacaacaa aggctaaaca gtcacattca
    11341 gatgtgaaat atgaagaaaa ttgttttata gtatttggga aagaaacaaa gggattacca
    11401 gaacctttgt tgaaagcaaa tatggatact tgtattagag tgcctatgtt ggatgttgaa
    11461 aaagctaggt cattaaattt atcaaattca gttgctattg tagtgtacga ggctttaaga
    11521 caaataggat acccaaatat gaggtagttt caacaagcct aaatgagaaa ggagcatact
    11581 taatgaaaaa tctaaagata atctgtgaca gtttatcgga cgtgccaaaa gatttgttag
    11641 ataaatatga tatagatata gtttcattaa cagttatact ggaggaaaga gaatacaagg
    11701 atagaattga tatatctgga gatgaatttt ataaaaggct tagagaagaa aatgtatatc
    11761 caaaaacttc tcaagctact tatgcccaat ttaaggaaat ttttgagaaa tatacaaatg
    11821 aggatagaga gatactttat atagcagggt ctgccacagc tacaggtacg tatcaaagtg
    11881 ctgtaatggc aaagaatgat gtagatggta aaatatatac atatgactct aacttgcttt
    11941 gtatgggaac tggtttactt gtaataaaag caggagaact tgcaagtgaa ggaaagtctg
    12001 ttgctgaaat attgcctgtt ttggatgaat taaaagagaa ggcttttgtt atattttcag
    12061 tagatacatt ggaatattta caaaagggag gtagaatatc atctactaag gcagcaatag
    12121 gaagtatatt aaatataaaa ccgattcttg aaataagaga tggattagtt tcgcaaatat
    12181 ctcaagtaag aggaaagaag aatgtaattt ctaagatgat ggaattgata aaatcaaatt
    12241 gtggtgatga tttatcagac caaattgtgt atataggata tagtgatgat tttaaggaaa
    12301 aagaacaatt atctaaggtt atgcaagatg aattaagacc taaagaaatt agatttttcc
    12361 aaattggtgt gtgtataggt gcacatgctg gtcctggtgt tactggtatc atatgcttaa
    12421 aaaataaata atatattttt ggatgacatt atttattttt ttattaaatt aggatagaat
    12481 attaattgtt gagatgttaa attggattta ttttggatga aattaagtgt tgatatatta
    12541 gatttagttt gtagggaagt gtgtaaatag ataagaatct attgcacact tttttatagt
    12601 aagatttatt aaaaaaattt caaaatgtac ttgtaaattg tatataaaaa aattataaat
    12661 aggatgtaaa agtaaatagg atataaaaat atcgtaaatg tatgaggagt gaaatttaat
    12721 gcgtttcaaa agaatattga tattgatgtt aactgtagca atgatagctg gaatgttggt
    12781 tgggtgtgct aataacccaa gtaataatcc tagctctagc aaagataata aaagtgatat
    12841 aagcgataaa agtaattcaa aaaaatctgt atcaatgata ctagatattg aaggaacaaa
    12901 taatgaagct atgaataatt cagctttatt agcattaaac aatgctcaaa agaaacttaa
    12961 tatagataca aacaaagtgg aatcagatga ttcctcaact ttttctaata gtatagatat
    13021 tttatgtaat gacaattacg atttaattat agctgtagga gctagatttg caaaaccatt
    13081 ggagatggta gccaagaaat atccaaagca acaatttgca attatagact atgagtatga
    13141 caagcaacct tctaatataa cttcaatttc ttatgaagat aataaatctg gatacctagc
    13201 tggattaatt gctggaaaaa tgactgaaag cgataaggtt ggttttatag gaggaacaaa
    13261 gagttctagt agagataaat ttgaatcagg ttttagagag ggtgttaaat tttctaatag
    13321 tagtataaag gatatttcag ttgagtatgc agatgttttt aaagatagca aatcagtaga
    13381 atctatagct aaaaaaatga tggataatgg agtggatatt attttttcta ctactgaaga
    13441 tgattcaaaa gctgtaatag atgcagtaag ggcaaaaaat aaaaaagtta tagcaacgaa
    13501 taaagaccaa catgagttag ctccagaaaa tgttataagt tctattgtaa aagattttga
    13561 gaatcctact tataatctga tacaaagttt tgtaaaagga aattataaag gcggaaaggt
    13621 tatagaaaac acagttaagt ctggaagtac tggacttgcc caaaatagtt ctcaaaatat
    13681 tcctccagat gtgttagaat atgttaataa gaacaataaa taatctacta taatatccaa
    13741 gaatacttat gagtttagtt atgaggtgaa ttggatgtta taatagacat atatagaaag
    13801 acatatgcag aggtaggtca gacctatcta aatcagggag tgaattttgt gaaaataaaa
    13861 aggatattga tggcttgctt tgtagtagtt tttacaattt ttatattagc tatatgtaat
    13921 tttgattttg ggtttgataa agtaaataag aataattcta atatagatag tgctaaatcg
    13981 aaacagagtg agtctaaaag tttgctaact tcagcagaaa aggataaatc aaatagtaaa
    14041 agtaagaata aagaagatga cacagaagat gattcatatg taagaaaaac tattggagta
    14101 ttgttagata ccgaaaactt aaataacgaa tcatataata acaatgtact atcagcctta
    14161 aaaagggctg acgaagattt tgatgttagg ataaaacttg aaaaaccaaa gacttctaaa
    14221 agttttaaag agagtataga aaaactgcat aagtatgaac cagattttat aatagcagtt
    14281 ggagccagat ttgcagagcc aattaaagaa gctgctacta aatatcccaa acagcaattt
    14341 gcaatagttg actatactta taaagttcag ccagctaatg taatttctgt atcatttcaa
    14401 gataatgtta ctggatattt agcaggactt attgcaggta aaatgactga tactgggaaa
    14461 gtcggtttta taggaggagt tgagggttct agtagagata agtatgaatc tggatttaga
    14521 aaggggctta aaacttcaaa taaagatgct gagttactag ttaagtattc aaatatattt
    14581 gaaaaccctg aatcagctag aactattgca aaggaaatga gagattctga tagagatgtt
    14641 gtattttcag ctacagaaga tgatagtaaa agagctattc aggtagcaag agaaaatggt
    14701 ggtaaagtta tagctattaa taaagaccaa tacgatatgg ctccagataa tgtaataagt
    14761 tcaattataa aagatgtaga acaacctgta tatgaactga taaagaacgt tgcaaaagat
    14821 ggttttaagg gaagtaaagt aatggaattt aaaataaaag atggggaact tggcttgact
    14881 tcaaagagca gtagaaatat accaccagat gttttggaat acataaaaaa agagtataac
    14941 aaagtgaaag atacatatta attattgatg tagaagatta taaaaatata ttgcttaagt
    15001 ttagattagc aataaaaaga tatatttatt aaatttgtgc taactgtaca aaatatattg
    15061 attaagttta gattagtgat aaaaagatat atttattaaa tttgtgttaa cagtatggaa
    15121 tatactgctt aagtttagat tggtgataaa aggatatatt tattaaattt agtctaactg
    15181 tacaaaatat attgattgag tttagattag caataaaaag atatatttat taaatttgtg
    15241 ctaactgtac ggaatatact gcttaagttt agattagtga taaaaagata tatttattaa
    15301 atttgaacca actgtacaaa gctatactaa ttaagcttag aataactata taaaattata
    15361 acaataagtg tgtgggcaga aaaattctgc tacacacttt atttatattc acataaaaaa
    15421 tttatcaaaa aaaagaaaaa ggagtaaaaa atggaattta caagagaacc atttatacta
    15481 gatgacgatt tgtgtctagc tttggtggac aaaagaatta gttatctaat ggaaaatgaa
    15541 ttaaaattaa gaaatataga gataataaaa acaatagaat gtaaagaatt atatgaaagc
    15601 ataaaatatc acccggatat atgtatttgt aatttaggaa aaggagatat aattgttgcg
    15661 ccgaatgtat ataatcaata caaagagtta ttaagtagat ataaatttaa tataattaag
    15721 ggagaagcta atttattaaa tagataccct tatgatatac cttacaatat tgcgatagtt
    15781 ggtgactatg ctatacacaa ttttaagtat actgacaaag caatattaga ttatattgaa
    15841 aataataaac ttaaaaagat aaatatagag cagggctatt ctaaatgctc aatctgtata
    15901 gtagatagaa cgtctataat aacatcagat aaaggtattt ggaaaagtat gaagaataca
    15961 gaaatagagt gtttattgat agaaaaaggt cacataaatt tatttgagat gaattatgga
    16021 tttataggtg gatgtacagg gttgatttct aaggataaac tagctttttg tggagatgtt
    16081 aaaaaacatc ctgactatga acgtataaaa agttttgtag aaagtaaaaa caaggagata
    16141 gttacactta gctgtgaaaa tttactagat ataggttcta tagttcctct catgacaaga
    16201 aaggagcgat aactttggtt gagaaggata atatttcttc catgaaattt ttgaggaata
    16261 ataatgtaaa cgatagatta atatatacga atgacattgt agaagtagtg atagattctg
    16321 caaagcaaga agtgttaaat aaaaaaatac ttaatggtac taaagctgaa caaagagctt
    16381 taaatattga tgagatatca acggaaataa ctagtatgat aataagtata atgaaagaga
    16441 aacttttgaa agaatacatt ctaaaatgct atgggcgtac atatcctgaa gataaaaata
    16501 atatatacat atattcactg aacatatttg ctaaaaaaga gatttttatg agagaaacag
    16561 tatttactag ggtgagaaat tatatagaag aaaatgattt tataaatgta gaaggtttta
    16621 ttagatttag aatgagagaa tttatgaaat atatttctgc tataggtgat attgcagttg
    16681 aggagtattt aataaagaaa gaccaagatg aatttataag agttttaaaa tactttatag
    16741 atactcaaga agaaaagatt gatttgctta aagttcatat aatggaagat aatacatttg
    16801 ttttatacga taaaaatgga aataagatag acagtataga tgatgaagaa attataaata
    16861 tggtaataag agaaaattta aattatgagg actttttaat aagtacctta ttaactctat
    16921 gtcccaaaaa aatagaaata ttggatttgt taaataataa ttgctcaaag gaaattatag
    16981 atactgtaga agcaattttt gaaaataaag ttagtataat tatggaaaac tagaatctaa
    17041 gcatataaaa gctatccata taaaattaaa aaaattcttt ttaaatcgac acaaaagact
    17101 tataattgta tataaagcta tagtataact agagttatta agtataaaga atatctactt
    17161 gattaatgca atatagctgg caaatataca attgataagg agtaatttta taatggataa
    17221 tttaattagg atactgatat tagctgttat tggtggattt ataggttatg ttacgaatgt
    17281 agttgctata agactgatat ttagaccaat agagcctatt aaaataccta ttttaaatat
    17341 agaaatagta ggtcttatac caaagagaag agcagaaata gcagcaaatg taggagaaat
    17401 aattcaagaa gaatttcttt ctatggacga aatacttgca aatatcatta ctgacgaaga
    17461 taaggaagaa gttgtaagat acataaaagc aagggtaaaa attataatac atgagaaagt
    17521 ttcatttatc ccgagtggta taaaaaacat gatacaagat tatctaggag agataattga
    17581 gtctgaagtt aagcaaagta tagatgaatt gagtaaaaat ataataaata aagcaaatga
    17641 acgtatagat atacaaaaaa tggtcgaaga taagattaat gaactagatt tatatgaatt
    17701 ggaagagata ataataagaa tagctaagaa agaattaaaa catatagagt ttttggggct
    17761 tgtcttaggg tttttaatag gtatagctca agggttaatt actatgttta tttaaatata
    17821 tgagaagtag catttattta agtactaatt atatttacct atttgagtga attacttatt
    17881 aataacattt agatattaat tgtatttacc tatttgagta aattacttat taatagcatt
    17941 tagatattaa ttgtatttac ctatttgagt gaattactta ttaatagtat ttagatatta
    18001 attgtattta cctatttgag tgaattactt attaatagca tttagatatt aattgtattt
    18061 atttatttga ttgtgttact tattaatagt atttaagtat ttactgtact acttattaac
    18121 catattaagt attgattgta tttaagtata caaaacctaa aaagagtaca aaaattagaa
    18181 gttagtttta ataaaaatta gttttagtat ttatctagtc atatctatca tgcatgtgga
    18241 tacgttttaa aaattttaaa tttatgaaaa tattataata taactataaa tcaagagatt
    18301 aatttaatat aaaaatataa gaatattggt ttacagctga ttgagatgaa aaataatggg
    18361 taattaatat attacattaa tgttgattga tgtataacta tctgttataa tgaaaatata
    18421 ttaaaaatca tagtgttgaa gaggaagagt agagtagaaa ccattctcag agaatttggg
    18481 tctatggctg agagcccatg taataggtct atttgaaaac taccttggag ctgagcttat
    18541 tagcagtatt tgtatttata ctatacgtga aagtgctcgg gtgacgacct tatagtcatc
    18601 aagagggttg tatatacttg tatacgccaa cttgggtgga accgcgaatt aatatcgtcc
    18661 caaacatatt tggggcgatt ttttattaca aaaaatctaa aaattatttc aataaggagg
    18721 aaaaaacaat gattaaagtt gctttaaaag atggctcaat aaaagaattt gaaaatgcta
    18781 tttctgttat ggatgtagct aaatccatta gtgaaggatt agctagaaat gtggtagcag
    18841 cgtctgtgaa cggagaggtt gtaggtctgg accacattat agatactgat tgtgacttga
    18901 atttatttaa gtttgaagat aaagaaggta aggaagtttt tagacataca tcagcgcata
    18961 tattagctca agctataaaa agactttacc cagaagcaaa gcttgctata ggaccaagta
    19021 tagaaaatgg attctactat gatatagatt tagaccatag attagttcca gaggacctag
    19081 agaaaataga agctgaaatg aaaaaaatag ctaaagaaga tttaaaaata gaaagatttg
    19141 aacttcctag aaatgaagct ttagagctta tgaaagaaca aggagaagac tataaggtag
    19201 aacttatttc tgatttacct gaaagtgaaa taatatcttt ctacaagcaa ggtgatttta
    19261 ctgatttatg tagaggacca catttaccat ctactaaaaa ggtaaaagct gttaaattac
    19321 aaagtgtagc aggtgcatat tggcgtggtg acgaaaataa taagatgctt caaagaatat
    19381 atggaacttc ttttgagaaa aacaaagact tagaagagta cttacattta ctagaagaag
    19441 ctaaaaagag agaccacaga aaattaggta aagaattagg attatttatg atacctgaag
    19501 aaggtccagg attccctatg tttttaccaa aaggtatgga acttaaaaat gaattattaa
    19561 aattctggag agaaatacac agaaaagctg gatatattga gatagaatct ccaatcatat
    19621 taaatagaaa attatgggag acttcaggac actggtatca ttacaaagaa aatatgtata
    19681 cagttaaaat agatgatgag gattatgcta taaaacctat gaactgtcct ggtggattaa
    19741 tttactataa ctctcaacta cattcatata gagatttccc aatgagagtt gcagagcttg
    19801 gtagagttca tagacatgag ttatctggtg cattacaagg attaatgaga gttagagcat
    19861 ttactcaaga cgattcacat atattcatgt taccagagca aattaaggac gaaataaaag
    19921 gagtagctaa cttaatagat ggtatataca aaacttttgg atttgaatat aatttagaat
    19981 tatctacaag accagagaac tctatgggaa gcgacgaaga gtgggaagca gcagaaaatg
    20041 gattaagaga agctttagaa gagttaggtc taccatatac tattaatgag ggtgatggag
    20101 cattctatgg tcctaagata gacttccatc taaaagattg tttaggaaga acttggcaat
    20161 gtggtactat ccaattagat atgcagcttc caagacaatt tgataatact tatattggtc
    20221 aagatggtga aaagcataga ccagttatga ttcatagggt tgcttttggt agtatagaaa
    20281 gatttatagg tatattaata gagcattatg ctggtaaatt cccagtttgg ttatctccaa
    20341 ctcaagttaa gatacttcct atatctgata aatttatgga ttatgcaaat gaagttaaga
    20401 aagagttatt tgataagggt ataagagttg aattagatga tagagctgaa aaaattggat
    20461 ttaagataag agaagctcag cttgaaaaag tgccatacat gttaatagta ggtgaaaaag
    20521 aagtagctga taataatgtt tctgttagat caagagataa aggtgaaata ggtagtatta
    20581 aattagatga atttatagct agtatttcaa aagaaattga atcaagagaa agtattattc
    20641 aagactaata tatattatat tagtagctaa gatattgtta tataagataa gtttaatcaa
    20701 tatgttgata tgttgatgca tagtgattaa atttatgaaa agatgagtat aattagaggt
    20761 acagttaatc atatttttat gattaatgta cctctagttt tttgtatggt agatttatta
    20821 ataaatatat catagaagtg ttttgaacat ggaaatattt atgtgcattc tttaaataaa
    20881 agtttatttt ttgagtgata attaagtgct tgttggtaag gttatggctg taaaaatcat
    20941 aactttattt tcatatttgt tccattttca taaaaattat tatcccttta agaaaatttc
    21001 ttaatcctct tgaaatattt cctttttagt ctaaagttaa atttctttct tcaaaatgaa
    21061 tatttaaatg aactaaaatt taagtacatt ttctaatctt atgagtctat ttttcataga
    21121 taattgccct ataatagaag aatctatgtt ggtgctatgt ggtgacaata acagcattgt
    21181 cagtgattaa ttaatgcttt ataaatgatt aattagtgtt ttatgttatt tttggactta
    21241 tcctctatac atagattaat ttatttaact ttagatagag agagaatgtc aagtacatac
    21301 acagacatta gagtttaaga aagtgtttat ggagcaagaa cttttaaaag aggtagtgac
    21361 ttagtttaat ttcaagaaat gataaataca aaagaggaaa aagagaggtg ttgaaatgat
    21421 agaaaaagta gaagaaaaat ctaagattat taaaacatca aaagaatata agcgaactat
    21481 aattgaagaa aaagataaag aatggaccaa aaaattaaat gatatactta gtagaagtag
    21541 tttttctaat gatgaattag ataaaatcaa ggcattaatt ccaaaagaga ttttgactaa
    21601 tgaaaatgtt ggagaagttg tgactgaaga tggatatgct aagcctgagt atgatgaggt
    21661 atttaaatca ttgttcactt taaataatga atatgattta cttgtaaatt ttataaatga
    21721 tattctaaaa gatgctccat atgctaacag gaatatcaaa ccgttcactc aaataaagag
    21781 aataattaga gttgaaactg atccaacaat taattacatt ggagagaaaa gacctaaact
    21841 tgatattttg gctgaagatg aagaaaataa tcatataaat attgagatgc aaagagcttt
    21901 tgagaacgat tatttggaaa gagctgaata ttatcttagt cgtgtacatg gtagaaagtt
    21961 agaagaaggt aaagagtata aagaaattgg aaaaactatt ggaatacata tactaaatca
    22021 tgtaaaatat aatcacatag aagattatgt aaattgcctg agattaacaa tggacgggca
    22081 tccagatatt tattctagta aaactgcatt atattttata gagcttccaa aaattcataa
    22141 atctgactat atagtaaata gaattatgct atggggaaaa cttattagta atccttctaa
    22201 cttagatgta agagttatag ctaagaatga ttctattatt aaaaaagcac ttgatagatt
    22261 aaaagaatta ggtagcaatg aagaatattt attaaatctg aaaagaggtg cttatatcat
    22321 gaataaaagt agaaatttta aagaagagat tgaaagagag acagcaatta gagttgcaaa
    22381 agaaaaagat tataaaataa ttataatgtt gaaaaaaaat ggttttaaat tagatgacat
    22441 attaaataaa tttaatgatt ttgacttaag tgaagatgag ataaaagaag tatatgaaaa
    22501 taattgatga taaataaaaa gtgaacttat ataagtttgc tgaatcggag tctggaaata
    22561 tttatatgta ttttttaatg aatgaaaatt tattttaaaa acaataattt agaagtacag
    22621 ttaattatat ttttatgata ctgtacttct agttttttct attgtagatt tattatttac
    22681 taataaatct acaatagaaa tgcttttgtt gtaagaatca ttttatctaa tgattgtttt
    22741 ttataatagt taaatttcca tttgtagtgt ttaaatataa atctataaca gcatttctat
    22801 aaatgttata aatcactata atgattcaac tcaaagttac tgcttaaaga agcagagatt
    22861 ttatcaaggt atatcatgga aaaaaatatt ttattgtaat atttataaga ttttattata
    22921 gaaataatgt aaaaacttta taaataatat attttatacc tagttataga taaatttata
    22981 tagttattat taaaaaaagc aata
//
LOCUS       DAEHWM010000066        22844 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.067, whole genome shotgun sequence.
ACCESSION   DAEHWM010000066 DAEHWM010000000
VERSION     DAEHWM010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22844)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22844)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22844
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.067"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            223..1659
                     /locus_tag="KNP36_002527"
     CDS             223..1659
                     /locus_tag="KNP36_002527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBF0874388.1"
                     /translation="MICTIKPLKISIKKSTEPLIEFISDTTYKNKSSSYIKEVYFTRY
                     IGVDDSIDKYIEKIKNIDTYFFNNPTIPYIRLNNLKINFDKEQTDKMLKIFNIYNSSK
                     FNSWDLYNIDFPCKIENDTLNWTKKIAFKNTLDLFSTSMPNCTSSIIKNFAVKLLCWI
                     DYFLPKLFYNKVKTTISPKIVYFGNIKRQELFFLYFLSQLGCDILYINPNKDILDLYP
                     ECSKFSTLFELSRKTPNILEIPFERHITNINYSENTNKTSPTTNKPNSKNTLNNTNLT
                     SKKIVQDEEVELSYEDLAKLSASVVMIVVCNNENKPFKSGSGVVINNEGYILTNLHVV
                     NDGYSFLVRFENDDKVYTSYQIIKYHSDYDLAVIKVDRKCKPIPVKVSKKPVRGQKIV
                     AIGSPLGLFNTVSDGIISAFRDFETVQMIQFTAPISSGSSGGALLDMFGNLLGLISAG
                     YDDGQNLNLAVESSLVKIFANNFIEIVN"
     gene            complement(1751..3625)
                     /gene="asnB"
                     /locus_tag="KNP36_002528"
     CDS             complement(1751..3625)
                     /gene="asnB"
                     /locus_tag="KNP36_002528"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBF0874389.1"
                     /translation="MDGNISIYYKGDISKKEDIKFKIKESVNNTRLSSRIEYKDEEKT
                     FDFERFNVIDAIYGNKPFEKDGKVIVFNGNIYNYHEIKEELIKKGHNFTTNDDIEVLL
                     ASYIEFGKNCVHKIKGMFNFIIYDRENESIFGARDLFGIKPLYYINKENAIIFSSEYK
                     FLLEYMKNLNINERSLQSYFSFQYVLPEDTMIQGIRLIPAGHYFRVENGILSLKRYNK
                     LEFRSSTKFFYTKNHLGNRDVNEDDIRNIVVDSIVTHMEEEKEIGTFLSGGIDSSIIT
                     TVASQINPNIKSFSAGFSVKGYSELEVAKKTADKLGIENIQINITQDEYIKSLPNVIY
                     SLDDPIADPSEVGLYFLIKEAGKHVKVALSGEGADELFGGYNIYKEYSTMKSVVNSPT
                     YIKSILGRVSELMPNIKGRNYLYRATTPLEKRYIGNAKVFENSEVKRFFFKYKEKNIY
                     EYLLSNLYRDAQKNNYDYISKMQHIDVNTWLQGDILQKISKLSTAEQVELRVPFLYKD
                     VFDVAKNLRMEQKINKNNTKVLLREAFREIVPEHVVQRKKLGFPTPIRVWLKDSLGDI
                     VKETIYNSNVDEFIDKKYAIKLLDTHLKGHRDNSRKIWTIFTFCLWHQLFIEHKNVEY
                     "
     gene            3828..4502
                     /locus_tag="KNP36_002529"
     CDS             3828..4502
                     /locus_tag="KNP36_002529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HBF0874390.1"
                     /translation="MSLFIISQCITSFAFTPENNKFKVKPLPYAYDALEPYIDKETMK
                     LHHDKHYQAYVDKLNAALEKYPELYNYSLCELLQNLDSLPKDIATTVRNNAGGAYNHK
                     FFFDIMTPEKTIPSESLKEAIDRDFGSFEKFKQEFQKSALDVFGSGWAWLVATKDGKL
                     SIMTTPNQDSPVSKNLTPIIGLDVWEHAYYLKYQNRRNEYIDNWFNVVNWNGALENYK
                     NLKSQD"
     gene            4615..5151
                     /locus_tag="KNP36_002530"
     CDS             4615..5151
                     /locus_tag="KNP36_002530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBF0874391.1"
                     /translation="MIKETHERGGYIFALLILPFINNLYLVKYDIAYKIVLIIIYIYF
                     AYLGSLFPDIDMRGSYISKKFMLIYKLFGSRFRHRGFTHSLIALLLIYSFFKSLTIFT
                     NNNIVFSCLSSGFIIGYLSHLCLDLITKEGIELFYPITINISLLPIKTNSKTEKFISK
                     LLNFIVIFLIGYQFYILL"
     gene            complement(5317..5937)
                     /locus_tag="KNP36_002531"
     CDS             complement(5317..5937)
                     /locus_tag="KNP36_002531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HBF0874392.1"
                     /translation="MQYIQELLDLTQNYWVLATIIGLLSAFIESFIPALPLVAIVTAN
                     AAIQGLFIGCLLSWIGSGLGTTSLFLLISRFNDSKLFNKLRNSKTEKAISWMDKQGFK
                     LLFIAYACPFMPGCLVTIASAFGKKDLKDFVPAMLAGKFVMFIVISYVASDIEGFITS
                     PLKIASFILLVFLSWKIGNRVNKNLENHNYDFHHKKHHNDKDDKMI"
     gene            complement(6251..8389)
                     /gene="vanT"
                     /locus_tag="KNP36_002532"
     CDS             complement(6251..8389)
                     /gene="vanT"
                     /locus_tag="KNP36_002532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine racemase VanT catalytic subunit"
                     /protein_id="HBF0874393.1"
                     /translation="MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSII
                     ARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMN
                     NLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKRLGLKYSLVITIVIYVIGMFG
                     DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLI
                     GFLISFLLMLCEGMFLHKLGVQRHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSL
                     IIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIASIIIILILKPLKKD
                     LKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCA
                     NQIGVKAFAVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAI
                     SLNKQKYNIKSHIKIDTGMHRLGFDVNDVRSILKAFKLKYLDICGIFTHLCVSDSLKD
                     EDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIGIALYGI
                     LSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYA
                     DGIPRNLSCGKSYVIINGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSE
                     LSASEVANNSCSISNELLSRVGRRLNVIKK"
     gene            complement(8407..9213)
                     /locus_tag="KNP36_002533"
     CDS             complement(8407..9213)
                     /locus_tag="KNP36_002533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBF0874394.1"
                     /translation="MMNNILLDKNKEDKMTNTILLTKDKVYDGNLILVNAFLPVKTSE
                     DIDLIPVDTRFPSILMKREATNILQNILKSICGINEIVPVSGYRTAEEQQDIYSSSLR
                     DNGKDFTKKFVALPNHSEHQTGLAIDLGLKKEVIDFICPEFPYNGICNEFRKAALHYG
                     FIERYQCKKEEITGISQEPWHFRYVGYPHSEIINKMNLALEEYIEYIKRFSYTNCLKI
                     EDKEKIIEIFYVPIHTKEEVRISIPEQCVYQISGNNKDGFIVTFWRNRKD"
     gene            complement(9210..10310)
                     /gene="vanG"
                     /locus_tag="KNP36_002534"
     CDS             complement(9210..10310)
                     /gene="vanG"
                     /locus_tag="KNP36_002534"
                     /EC_number="6.3.2.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-serine ligase VanG"
                     /protein_id="HBF0874395.1"
                     /translation="MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGIT
                     REGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNS
                     AIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
                     SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEE
                     LQVAVDLAFEHDNEVIIEENIDGFEVGCAVLGNDDLLVGRVDEIELSKGFFDYTEKYT
                     LKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIP
                     GFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK"
     gene            complement(10571..11653)
                     /locus_tag="KNP36_002535"
     CDS             complement(10571..11653)
                     /locus_tag="KNP36_002535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874396.1"
                     /translation="MRTALMAFIAIIFIWILYSFILYGKFSIWIVSFFENAFRMEYKA
                     ALNLYQQIFRNSMELFMILAMVIVFFIIFRVYLNWFTKYFSEINQGIDSLIKEDVGEV
                     ALSPELLAIEKKINSIKHILEQRKFETQMAEQRKNELIVYLAHDLKTPLTSVIGYLTL
                     LRDESQISEELRKKYLSISLDKAERLEDLINEFFEITRFNLSNISLEYSTVSLTRMLE
                     QLTYEFKPTLMSKNLKYTLNVTPNMMIRCDVNKMQRVFDNLLRNAVYYSFEDTTIEIT
                     AVQEDDYIKLKFINHSNTIPEEKLERIFEQFYRLDTSRNSNSGRAGLGLAIAKEIVEL
                     HNGTITAHSENNIIIFKVIIPIVGNL"
     gene            complement(11703..12404)
                     /locus_tag="KNP36_002536"
     CDS             complement(11703..12404)
                     /locus_tag="KNP36_002536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanG-Cd-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="HBF0874397.1"
                     /translation="MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIES
                     KNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITK
                     PFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
                     TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNP
                     KFIKTVWGVGYTIEK"
     gene            complement(12838..15369)
                     /locus_tag="KNP36_002537"
     CDS             complement(12838..15369)
                     /locus_tag="KNP36_002537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBF0874398.1"
                     /translation="MSLKSLKIKENLYWVGSLDPDLRVFDIIMYTPYGTTYNSYVLKG
                     TEKTVLFETVKDKHFDNYIERLNDLNIDFEKIDYIVVSHTEPDHAGSVEKLLDLAKNA
                     KVVASETAIKYLKEIVNKDFEYVAVTDGDTLSIGDKTLEFFSVPMLHWPDTIYTYIKE
                     DKTLVTCDSFGSHYSNDKIVNTLDENEEKDYLDALRYYYDCIMGPFKPSMVTAIEKIK
                     DLDIDTVCPGHGPVLTENPRKIIDLYYNWSVNEQIKLEKEVTICYVSAHGYTKIMAEA
                     IKAYIEKNSNYKVNLFDVIEHKQEDILAKIAVSQGVLFGTPTILGDALKPIWDILISL
                     NPVLHGGKVASVFGSYGWSGEGIENAMERISQLRMTAVKPFAVNFKPSNEEIDKLYSY
                     TGKFLDKLNSTFGSKKKTKKFKCVICNEVFEGDSAPSVCPVCGAKEDQFIEVEEDEVT
                     FRKDTDEYFVIVGNGAAGFYAADAIRKRNKTCKITMISNEDELTYYRPALSDGINEEL
                     GSDFYMEDKDWYDKNNIVVILGTNVDKLDEVNKTIIVNDGAIKFDKLVIATGSRNFIP
                     PIKGHDLENVFTLRNIKDLYSVKEALEKSKKVVVIGGGLLGLEAAWEFRLKGLEVVVV
                     EAMDSILSKQLDKEGSKILEQCVRDTGIDVRLGVAVDGIEGDGKAQKVVFKDGDSVDC
                     DMVVFSIGVRANTQMVQDTSVKIDRGIVVDKTLQTNVKDIYACGDVAQVGNISLAIWP
                     SSVEMGKIAGANASGDNLTFESEVYPVSLDAMNVKVFSIGNIQNFDKEISSKDEGQRI
                     YKKLFMKDGSLVGAILINDLSCTVKLIRLISEKGDFEDIMKADIL"
     gene            complement(15477..16094)
                     /locus_tag="KNP36_002538"
     CDS             complement(15477..16094)
                     /locus_tag="KNP36_002538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PepSY domain-containing protein"
                     /protein_id="HBF0874399.1"
                     /translation="MCKKTYLLVVSMLIAGLLTACSGSPTKDSGQAQDNTKKEANASN
                     NALKDEKNNENLMEQDFKVPYTDAINIFKDKYKDADIVDLSLERDLNKFVYTVEGVDD
                     NNEYKMKIDANTKDVLEDKTEKLDSEDLNGVARKEKLDLNDIMTPQQAMEIALKEQNG
                     IVKEWSLDKDLDVTFYKIRIDKDKNEYDIKVDSKKGTVLKVEKED"
     gene            complement(16456..17340)
                     /locus_tag="KNP36_002539"
     CDS             complement(16456..17340)
                     /locus_tag="KNP36_002539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HBF0874400.1"
                     /translation="MDTTKIDDISKLDLNNLDINKMDMGGIMESLLEWATTSGVKLII
                     GILILSIGFKIIKKFVNHVMLLLSKRDIDLTLRKFLKSLLLSVLKVAVIIIVLEYWGM
                     SLSSFAAVIASAGVAIGLALQGSLSNFAGGFIILLIRPFKVGDYVEAAGHGGTVEQIG
                     LFYTQLVTPDNKQILIPNGSVSNDSLINYSAKNTRRVDLTFSVGYEDDILHVRRVLKD
                     IVNNHKLIINEPEPFIGVVEHGDNAIKFATRVWCKTEDYWTIYLDLLEEVKVRFDEEG
                     ITIPYPKMDLTVKELNKI"
     gene            complement(17531..18781)
                     /locus_tag="KNP36_002540"
     CDS             complement(17531..18781)
                     /locus_tag="KNP36_002540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0874401.1"
                     /translation="MKSYTKAKWSVWGIITFSFVLVLFLRMSTAVVSDNLANELGFNS
                     IQISNIASFCLYAYAFMQIPAGILIDKYGARKISSLGIIMASLGSILFGLIQSIELAY
                     ISRVIVGAGTSVILLCILKIQGRWFNKSEFASATAKFSFVGNLGGVLATFPLVFLSEL
                     VGWRNSFLLIGIIGVVIGCFMYIIVRDTPKEYGFNVDTEPYEKSEKVNIVDGIKSVIK
                     NKSTWYNSMIMFSFVGLTSAFISLWGVRYIMDVYGVSKSFSAFIVSFFTYGFIFGSII
                     MDFVFAKIRSSKFNIIKFGAMIDLFIWIVIVVVYQVKPPIIVLPISFFIMGCIVMSHL
                     QVFNDAKYKNKEIYSGLATSVINTFEFIGSGIINLIIAISLQVNSYNIVDGYKKGFVV
                     FIVLSIITIVSSHIGVKNDDFKAI"
     gene            complement(19003..19767)
                     /locus_tag="KNP36_002541"
     CDS             complement(19003..19767)
                     /locus_tag="KNP36_002541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874402.1"
                     /translation="MLGKLLKYELKASGRIFIPLYIAILIVAVFNGIFMNTNILQVQG
                     IGILVLTSLFMALGVLTIVVTIQRFRKNLLGDEGYLMFTLPVSTSSLILSKCITALIY
                     AVLSFIVAVFTFGVLMLFGTSGILLPEILDLFNTSFKWISENFLDILLLVVVMFISYS
                     SFILLLYTSISMGQLPKFNKHRNIVAFASFIAINIVISIVGDAVGSILPNEDTNMVYH
                     LYQSPSFMLAILGSLVVAIALFFATKFILDKKLNLE"
     gene            complement(19761..20486)
                     /locus_tag="KNP36_002542"
     CDS             complement(19761..20486)
                     /locus_tag="KNP36_002542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874403.1"
                     /translation="MDKNISNVSQDGIVEFKGVNKSYGTKNVLKNIDLNIPKGKIVGL
                     LGPNGSGKSTMIKLMNGLLQPDNGEIMINGMKPSIDTKKIVSYLPERTYLNDWMKVSD
                     LLKFFYDFYSDFDVRRANEMIKSLDIDVNEKLKTMSKGTKEKVQLILVMSRNASIYIL
                     DEPIGGVDPAARSYILKTILKNYSEDSTLLIATHLISEIENICDEIIFISKGEIVLQG
                     DVEAIREEKGKSIDALFREEFKC"
     gene            complement(20488..20856)
                     /locus_tag="KNP36_002543"
     CDS             complement(20488..20856)
                     /locus_tag="KNP36_002543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0874404.1"
                     /translation="MEWELDNNKPIYIQLVEHLKLKIISGEIKIGSKLETVRALAEDA
                     EVNPNTMQKALTELERQGLVYSQRTKGRFVTDDKEKIKAMKEEIANVEINTLKVTLEK
                     LGYDRDEMLKLITENLKGEL"
     gene            complement(21032..22576)
                     /locus_tag="KNP36_002544"
     CDS             complement(21032..22576)
                     /locus_tag="KNP36_002544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBF0874405.1"
                     /translation="MRNLQKKLMFFLFICIILQITYTTPVYSLCKLYKNNSINNFESI
                     VSNNQLISKHAIQIILIMAIICVILIFYIIYDKLNFKIKLQRIAYTDNLTGANTIDKF
                     VIDANKILCKNTQVKYALLYIDIDKFKYINDLFGYEVGNEILRNLTKIIKSNIFEEEM
                     FARISADNFIIIMKYIEEEDITKRLKTIFEELDLFNNNQEEKYKLVLSCGIYFILPED
                     RDINSIIDRANIPHKMAKGGHKSSYAFYDNKIHDQEIKEKEMENTMFSSLENKEFIIY
                     LQPKIELNTGEIQGSEALVRWKRPDKGLIPPNEFIPFFERNGFVINLDLYVLEEVCIY
                     LRKWIDAGINPVTVSVNVSRIHLYCNNFIETYKNIIDKYNIPAKYIELELTESIIFDN
                     FDILIDIMNNLKKIGFLISMDDFGSGYSSLNMLKEIPMDILKLDQKFIMETYNSKRSK
                     IIVTKVIEMAKELGMKVISEGVETEEQFKLLKEVKCDMAQGYLFGKPMPIEEFEHLIV
                     SNLVRG"
BASE COUNT         7902 a         3842 c         2378 g         8722 t
ORIGIN      
        1 tagcggtatt agattacaag cattattcta acttttttta tattaagacc ttacctttca
       61 tccctacacc taaaggagag ggcttttcgg caattttatt gtaattatat atcatttata
      121 taaacaagta catattttat tttgaaacta caaaattatt gtactatatt gttttaagtt
      181 gttttataat agattatatc atcttattat aggagaaaaa atatgatttg tactattaaa
      241 ccattaaaga tttcaataaa aaagtctact gaacctctaa ttgaatttat atctgatact
      301 acctataaaa ataagagttc ttcatatatt aaagaagtct actttacaag atatataggt
      361 gttgatgatt caattgataa atacatagaa aaaattaaaa atatagatac ttattttttt
      421 aataatccta caattcccta tattagatta aacaatctaa aaataaattt tgacaaagaa
      481 caaacagata agatgcttaa aatttttaat atttataata gttctaagtt taacagttgg
      541 gatttatata atatcgactt tccatgtaaa atagaaaatg acaccttaaa ttggactaaa
      601 aagattgcat ttaaaaatac tttagattta ttttccacaa gtatgccaaa ttgtacatcc
      661 tctatcatca aaaactttgc agttaaactt ttgtgttgga tagactattt tctacctaaa
      721 ttattttata acaaggtgaa gactactatt tcaccaaaga tagtatactt tggaaatatt
      781 aaaaggcaag aacttttttt cttatatttt ttatcacaac ttgggtgtga tattttatat
      841 ataaatccaa ataaagatat tcttgattta tatcctgaat gttcaaaatt ttctactcta
      901 tttgaacttt ctaggaagac tccaaatata ttagaaatac cttttgaaag gcatattaca
      961 aatataaatt acagtgaaaa taccaataag acttctccta ctacgaataa acctaactct
     1021 aaaaatacac ttaataacac aaatctaaca tctaaaaaaa ttgtacaaga tgaggaagta
     1081 gaactttctt atgaagacct tgcaaagtta tcagcttctg ttgttatgat tgttgtgtgc
     1141 aataacgaaa ataaaccgtt taagagcggt tctggagtag taataaataa tgaaggttat
     1201 atacttacga atcttcatgt agtcaatgat gggtattcat ttttagttag atttgaaaat
     1261 gatgataaag tttatacatc ttaccaaatt ataaaatacc attcagatta tgatttagct
     1321 gtgataaagg ttgatagaaa atgcaagcca atacctgtta aagtcagtaa aaaacctgtg
     1381 agaggtcaaa aaatagttgc aattggaagc cctctaggtc tttttaatac agtttcagat
     1441 ggaattattt cagcttttcg tgattttgaa acggttcaaa tgatacaatt tacagctcca
     1501 atctctagtg gtagttcagg aggagctctt ttagatatgt ttggaaactt actaggattg
     1561 atttccgctg gatatgatga tggacaaaac ttaaatttag ctgttgaaag tagtcttgtc
     1621 aaaatatttg ccaataattt tattgagata gtaaactaat caatcaaaat tctacttatc
     1681 ctattccata ataatcaaga gggtgaaaac attgcatgct tttgccctct gattaatatt
     1741 gaaaaaagta ttaatactcg acatttttat gctcaataaa taattgatgc catagacaaa
     1801 atgtaaatat agtccatatt tttctcgaat tatctctatg acctttaaga tgcgtatcta
     1861 aaagttttat tgcatatttt ttatctataa attcatctac atttgaatta taaatagttt
     1921 cctttacaat atcccctaga gaatctttta accaaactct tattggagtt ggaaatccta
     1981 attttttcct ttgaacaaca tgttctggga ctatttctct aaacgcctct ctaagtaaaa
     2041 cttttgtatt attcttattt attttttgct ccattcttaa attttttgcg acatcaaata
     2101 catctttata taaaaatggt actctaagtt caacctgctc agctgtagaa agtttgctaa
     2161 ttttttgaag tatatcgcct tgaagccatg tattcacatc tatatgttgc attttactta
     2221 tataatcgta attatttttt tgtgcatctc tatacaaatt agacaacagg tattcatata
     2281 tattcttttc cttatactta aaaaagaatc tttttacttc gctgttttca aaaacttttg
     2341 catttcctat atatcttttt tctaatggtg ttgtagctct ataaagataa tttcttcctt
     2401 ttatgtttgg cataagttct gaaactcttc ctaatatact tttaatataa gtaggtgaat
     2461 tgacaactga tttcatagta ctatactctt tatatatatt atatcctcca aataattcat
     2521 ctgctccttc tccagacaat gctactttaa catgtttacc tgcctcttta attaagaaat
     2581 aaagacctac ttctgaaggg tctgctatag ggtcatccaa agaataaatt acattcggta
     2641 atgattttat atattcatct tgtgttatat taatctggat attttctata cctaacttat
     2701 cagctgtttt ctttgctact tctaattcac tatatccttt gacactaaag cctgcagaaa
     2761 aagattttat atttggatta atttgtgaag ccacagtagt tataatagat gaatctattc
     2821 caccagacaa aaatgttcca atttctttct cctcttccat atgagttact attgaatcta
     2881 ctactatatt tcttatatca tcctcattca catctctatt gcctaagtga tttttagtat
     2941 aaaaaaattt tgtactactt ctaaactcaa gtttattata tctctttaaa gatagtatac
     3001 cattttctac cctaaaatag tgacctgctg gtatcagcct tattccttgt atcatagtat
     3061 cttcaggaag tacatattga aatgaaaaat aactttgtaa gcttctttca tttatattta
     3121 aatttttcat atattcaagt aaaaacttat actctgagga aaaaattatt gcattttcct
     3181 tatttatata ataaagtggt tttatcccaa ataaatctct tgctccaaat atactttcat
     3241 tttctctatc atagattata aagttgaaca ttcctttaat cttatgtaca caattcttac
     3301 caaattctat ataagatgct aataagactt caatatcatc atttgtagta aaattgtgtc
     3361 cttttttaat taattcttct tttatttcat gatagttata tatatttcca ttaaaaacaa
     3421 taacttttcc atctttttca aatggtttat ttccataaat agcatcaatt acattaaatc
     3481 tttcaaaatc aaaagttttt tcctcatcct tatactctat tctactagaa agtcttgtat
     3541 tatttacaga ttcttttatt ttaaatttaa tatcttcttt tttagatata tcacctttat
     3601 aataaattga aatattgccg tccatataat caaaattcct ttctgtcctt tagtcttatt
     3661 ctatatttca tagttttgtc tttggcttta aaacttattc aatttaaaat gaaattgcta
     3721 ttaaattctt ataaattatc tgttaatatt tcatattttt tttatttcta gaaatactat
     3781 attaggaggt gatttttatg aagaaaaaaa tattaatacc agttattatg tctttattta
     3841 taatctcaca gtgcataact tcatttgctt ttacacctga aaataacaaa tttaaggtta
     3901 aaccattacc ttatgcatat gatgcacttg aaccttatat agataaagaa acaatgaaac
     3961 tgcatcatga taagcattat caagcttatg ttgataaatt aaatgctgct cttgaaaaat
     4021 atcctgagct ttataattat tctttatgtg aattattgca aaatttagat tctttaccta
     4081 aagatattgc tacaactgta agaaataatg caggtggagc ttataatcat aaattctttt
     4141 ttgatataat gacgccagaa aaaaccatac cttctgaatc tttaaaagaa gctattgata
     4201 gagactttgg ttcttttgaa aaatttaagc aagagttcca aaaatctgct ttagatgtct
     4261 ttggttctgg ttgggcttgg cttgtagcta ctaaagatgg caaattatct attatgacta
     4321 ctccaaatca ggatagccct gtaagtaaaa acctaactcc tataatagga cttgatgttt
     4381 gggagcatgc ttactattta aaatatcaaa atagaagaaa tgaatacatt gacaactggt
     4441 ttaatgtagt aaattggaat ggtgctttag aaaattacaa aaatttaaaa tctcaagatt
     4501 aattaaatat taaaatcctt ttgaaaaaaa cttatgtttg ctatataata taataaaaga
     4561 tagtctaaat ttaccaatat aatgtttata gtgacgattc aggaggattt ttatatgata
     4621 aaagaaacac atgaaagggg aggttatata ttcgcacttt tgatactccc ctttataaac
     4681 aatctatacc tagttaaata cgatattgca tataaaatag tattaattat aatttatatt
     4741 tattttgcat atttaggttc tttatttcca gatatagata tgagaggttc ttacataagt
     4801 aaaaaattta tgttaatata caaattattt ggaagtaggt ttagacatag agggtttact
     4861 cacagtctaa ttgccttatt acttatttat agttttttta aatctctgac aatcttcact
     4921 aacaataata tagttttctc atgtttgtcc agtgggttta taataggata tctatctcac
     4981 ttgtgtcttg accttattac taaagaaggt attgaattgt tttatcccat taccataaac
     5041 atttctttac tacctataaa aactaactca aaaacagaaa aattcatatc taagctatta
     5101 aatttcatag ttattttttt gattggatat caattttata ttttattata gttgtagaaa
     5161 aaataaataa caatattttg aactaagtat aaataagttt tatatatttt agtttacaaa
     5221 agaactaaaa attttgtacc ttaatacaaa aaataaaacg tatcttaaaa taatttagta
     5281 ctaaatcatt ttaagatacg ttttatttcg tacaagctaa atcattttat catctttatc
     5341 attgtgatgt tttttatgat ggaaatcata attatgattt tcaagatttt tatttactct
     5401 atttccaatc ttccatgaca aaaacaccaa taatataaat gatgctatct ttaaaggact
     5461 tgttataaaa ccttctatat cacttgccac gtaacttata actataaaca ttacaaattt
     5521 tcctgccaac attgctggca caaaatcttt taaatctttt ttaccaaaag ctgatgcgat
     5581 agtaactaaa caaccgggca taaatggaca ggcatacgct ataaataata acttaaatcc
     5641 ctgtttatcc atccaactta ttgctttttc agttttacta tttctcaact tattaaaaag
     5701 cttactatca ttaaatctgc ttattaataa gaataatgaa gttgtcccaa gtcctgagcc
     5761 aatccatgat aacaaacatc caataaataa tccttgtatt gcagcatttg ctgtaactat
     5821 agcaacaagt ggtaaggctg gtataaagct ttctataaat gcacttaata agccgattat
     5881 tgtggctaac acccaataat tttgagtcaa atcaagtagt tcttgtatat actgcatatt
     5941 gcttttcccc ttttttaact ttaactatta ttatatactc tatatgttta ttatatacca
     6001 atctcaaaaa atgaatctaa tattaaaaag taaataatct atataagttt acagttaagg
     6061 tataattatt ttattatata ttataacaaa aaaggtgatg tttcaaaata aaaatctgaa
     6121 acatcacctt tttataactt aaattgtcat gtaagttata aaaaatatat attagacata
     6181 atattactaa aaatgtctag tcagagtaaa ataaattaca cagtacaaca aatattacta
     6241 tttaattgag ttacttcttt ataacattta accttcttcc tactctgctc aataattcat
     6301 tcgatatact acatgagtta tttgcaactt cagaagcaga taattcagat aaattatctc
     6361 ttcctattat tattgccgta ttaccaactt ctacattagg tatatctgta atatcaacag
     6421 caagttggtc catgcaaatt cgacccacta ttgctgctct acaaccattt attattacgt
     6481 aactttttcc acaggataaa tttctaggta taccatcggc atagccaata gataatatag
     6541 caattacgct atctctgctt gcaataaaga ctcttccata tccaaaacta tcatcttttt
     6601 gtatttttct aataagaatt acttgtgatt ttaaggataa aacaggtcgt aaatcaagtt
     6661 gcaatttagt cgtatcattt ggagaactta atatcccgta taatgcaatt ccaattctta
     6721 cataattaca cttaagattg ggataattaa aaaaaccata actactttga atatgtactt
     6781 taggaatttt tatacctttt tttaacagaa aatcaattaa cttataaaaa cattcaattt
     6841 gtttatttgt aaagtctaca tcttcatctt tcagactatc tgaaacacac aagtgtgtaa
     6901 atatgccaca tatatctaag tattttaatt taaatgcctt taaaattgac ctcacatcat
     6961 taacatcaaa acccagtctg tgcatacctg tatcaatttt aatgtgtgat tttatgttgt
     7021 atttctgttt gtttaaagag atagcatgat taaggtcaat aacactctgt gtaagattgt
     7081 atttatgaag ttcctttgcc cttattgggt tagtatatcc aagaatcaat atttctccta
     7141 gtattccata tcgacgtaaa tcaatcccct catctattgt tgctactgca aatgctttta
     7201 cacctatttg gtttgcacaa gtcgctactt caaaagcact atgaccatag gcattagctt
     7261 ttacaactgc catcaattca caatcttctg gcatagcttt ttgtatcatc tttacattat
     7321 gttccaaatt atttaaatca atttcaatcc aagctctatt ggtatttacc ttatgttctc
     7381 ctttcaagtc tttttttaga ggtttaagaa tcaatataat aattatagaa gctataaaag
     7441 atgctatact taccactata taatgaataa ggctattgtc aaccaagaca gtttgtattc
     7501 cgaatatttt agaaaacata cgaataacaa caatcatcat aggatgtata atataaataa
     7561 ttaatgatga tgttcgcaat aacctagctc gagaaccttt caaaaatgtt aaggctgtaa
     7621 ataagaaata catacatggc aataacataa tatacatgct atcatgacgc tgtaccccta
     7681 gtttatgtaa aaacattccc tcacataaca taagtaagaa tgatataaga aatccaatca
     7741 agctattttt agttgacata taattagatt tattagatat tattccacca agtatgaaaa
     7801 atacaggtgc aaaaaatata ccatttcgtg tataatctga tacttcaaaa atatacccat
     7861 ataaattctt taatagtggt attttttcta aaaaaccata ataactatca ccaaacatac
     7921 caattacata aataacaata gtgattacta gtgagtactt taaacctagt ctttttacaa
     7981 gaaagtatgc aatacttgca ccaataattg atgcaggtag ataccataaa tgatataaag
     8041 tcccatcaaa tacaatgtcc ttaataatat tgggcactaa attattcatg gaaaaatatc
     8101 cagtgtaaat atttaaggga atataaatta caatagctat cccgtaaata aataatacat
     8161 tttttagaaa agatttcagt ttattacaat tataattata tgttgaaatt agaaaaaagc
     8221 ctgatagcat aaaaaagaat ggcacagcaa tacgagcaat tatactagtt aacacaaagt
     8281 cagccatttt actatatgat aataatggag atgtatgaat tgcaattata agtaatgcag
     8341 ctataatcct aaaataatca agccctgcat aagatttatt cctaatcatt cttgttcctc
     8401 catttcttag tcctttctat ttctccaaaa tgtcacaata aaaccatcct tattgttacc
     8461 cgatatttga tatacacatt gttcaggtat agagattctc acttcttctt tagtatgaat
     8521 aggcacataa aagatttcta taattttttc tttatcttct atttttaaac aatttgtata
     8581 cgaaaatctc ttaatatatt ctatatattc ttcaagagcg agattcattt tattgataat
     8641 ctcagaatgc ggatatccca cataacgaaa atgccatggt tcttgagata ttcctgttat
     8701 ttcttctttt ttacactgat aacgctctat aaaaccataa tgtagtgctg ccttacgaaa
     8761 ctcattacaa ataccattat aaggaaattc agggcagata aaatctataa cttctttctt
     8821 taaccctaaa tcaatagcaa gccctgtctg atgttcactg tgatttggaa gtgctacaaa
     8881 ctttttagta aagtcttttc cattgtcacg cagagaactt gaatatatat cttgttgttc
     8941 ctctgcagta cgatatccac ttacaggtac tatttcattt attccacata tactttttaa
     9001 aatattttgt aaaatgtttg tagcttcacg tttcataaga atacttggaa accttgtatc
     9061 tacaggaatt aaatctatat cttcagatgt tttaactggt aaaaaagcat ttactagaat
     9121 tagattccca tcataaactt tatctttagt caataagata gtatttgtca ttttatcttc
     9181 tttattttta tctaataaaa tattattcat cattttatgt acacctcaat tatcttgtcc
     9241 aatatttctt caaaagacaa tccaatacct ttcatcatat ttggataacg actatgagaa
     9301 gtaaagccag gaattgtatt gacttcatta aaaataattt caccagatgg agttaaaaac
     9361 atatctactc tagcaaatcc agaacatcca agagttctat aaataatttt tgctgtctct
     9421 tgtattcttt tctcacaatc caaatcaatt ctagctggca tatgaatttt tgaacttttc
     9481 aatgtatatt tttctgtata atcaaaaaat ccttttgaca attctatttc atctactctt
     9541 ccaacaagta agtcatcgtt tcctaaaact gcacacccta cctcaaaacc atcaatattt
     9601 tcctcaatta ttacttcatt atcatgttca aaagccaagt ctactgctac ttgtaactct
     9661 tcttttttat aaattttact aataccaaat gatgaacctg cacgcacagg ttttataaat
     9721 aatggataag ttaagtcttt tgacagttca gccacattaa atttatctga gtattttagt
     9781 aatattgatt ttggtacttt aataccttct gaatgaacaa gtttatgtga tttgtctttg
     9841 tccatacata atgctgaaga aagagtacca catcctataa cctgtatacc tgccaattca
     9901 aataacccct gcactgttcc atcttctcca ttttttccat gcagtacagg aaacacaaaa
     9961 tcaagtttag tgtatttaat atcattttca catgattcaa tagcactatt tggaatatga
    10021 ttctgagaaa cagcatcagg aattaaaaat tcaataatac catttttgac acggttctgc
    10081 gaaacaataa ctggaattat atcagtatcc ctttcaaacc aagtgttatt ctggatatta
    10141 ttataatctc caatataatg ataccaatta ccctcccttg taattccaat tggtataata
    10201 tcatattttt ccgtattcaa attctcaagt actgcaaaag ctgattgtaa tgatacatca
    10261 tattctgttg agtttccacc aaatataact gcaatttttt tattattcat ctttgattct
    10321 cctttgttga tttatttatt tttatacaat ctacagaaac atgttaaaat actttttcta
    10381 tttcaaatcc aatcaacctt cacttacaat tgcatctgtt ccacataata tattttcaca
    10441 tttttctatt gatataatta ctgtatcaaa ataaaagcac tcttgttttg atacagtaat
    10501 tatatcaata acaagagtgc tctttattta tttatcctaa agaatttcct atttttttat
    10561 acttaaattc ttacaaattt cctacaatcg gaataataac cttaaagata attatattgt
    10621 tctcgctatg agctgttatt gtcccgttat gaagctccac tatttcttta gctatagcaa
    10681 gtcccaaccc agctctacca ctgtttgaat tacgagatgt atccaacctg taaaattgtt
    10741 caaaaatacg ctcaagtttt tcctctggaa tcgtattgct atgatttata aatttaagct
    10801 ttatataatc atcctcctgt acagctgtta tttcaatagt agtatcttca aaactataat
    10861 aaacagcatt tcgtaataag ttatcaaata cacgttgcat tttattaaca tcacacctta
    10921 tcatcatatt tggtgtaaca ttcagtgtat attttaaatt cttactcatc aaagtaggtt
    10981 taaactcata tgttagttgt tcaagcatac gagttaagct tactgtactg tattcaagtg
    11041 atatatttga taaattaaac cttgtaattt caaagaattc attaattaaa tcttcaagac
    11101 gctctgcctt atccaacgaa atagataaat atttttttcg cagttcttca gaaatctgac
    11161 tttcatctcg aagtagtgtc agatacccta taactgatgt aagtggtgtt tttaaatcat
    11221 gtgcaagata aacaataagt tcattcttac gttgttctgc catttgtgtc tcaaatttac
    11281 gttgttcaag tatatgttta attgagttta ttttcttttc tattgccaat aactctggag
    11341 ataaagccac ttctccaaca tcttctttga taagagagtc aataccttga tttatttcac
    11401 taaaatattt tgtaaaccaa tttaaataaa cccggaatat tataaaaaac acaatcacca
    11461 tagctagtat catgaagagc tccatgctat tacggaaaat ctgctgatat aaattcaatg
    11521 cagctttata ttccatacga aaagcatttt caaagaatga tactatccag atagaaaact
    11581 taccatacaa tataaaagaa tataaaatcc atatgaaaat aatggctata aatgccatta
    11641 aagctgttct cataaaaatt ttatttctca cttgagtaaa gtcaggattg actttaatat
    11701 ttttactttt caattgtata acctactccc catacagttt ttataaattt cgggttttta
    11761 gaaggttcat gaattttttc acgtaatcgc cctatatgag ccataactgt gttattatta
    11821 tcaagatatt tttctcccca tacagcttca aacaattctt cagaaggaac cacttttcct
    11881 tgatgttcac ataaatacca aagaatagaa aattcaatcg gtgttaatgc tacttctttc
    11941 ccaaataaac tacatttatg tgtttcttta ttgataatca atcctttaat atcatactca
    12001 ttaacaatta tcgactgttg ttcataagaa ttattatatc gcatatatct tcttaattgt
    12061 gtctttactc ttgcaacaac ttccaaaggg ttaaatggct ttgttatata atcatcagca
    12121 cctatggtta aacccattat cttgtctata tcttcaattt tagctgttaa cataatgata
    12181 ggataatagt atttttctcg aattttctgg caaatatgaa atccatcaat atcaggaagc
    12241 ataatatcta aaatagccat atccaaattt ttagattcaa tacattctag agcttcctta
    12301 cctgtataaa acttgtatac tgtaaaacct tcatttttta aatatacttc aattaaatct
    12361 gctatttctt tttcatcatc cacaatcaaa atattttcgt tcatagatta tttttcactc
    12421 tccttattat cgaggtcatc atttataata ttggtaaatt tacatatcaa ataattacaa
    12481 gcatatttgt aactaatttt tataagaaaa gaactactac atcagaatgt gttgatgcta
    12541 ctattggaac acaaaaactg agattaattg ttattataaa aactccccta acacgtcctt
    12601 attatcgcat aacaggtatt aactttcaat aaaaatatct atcagtcaaa cacaattcaa
    12661 tttattatac cagagacaat ccatataaaa aacaattaaa cctatgtatg taaccacaga
    12721 cattactaaa atttccatgt tattttatat aaaaattcaa aaaaggagtt gaatttaaaa
    12781 tttgattaga aaaaaatcaa ttttgagaca actccttttt attttaatgt atttaaatta
    12841 tagtatatca gccttcataa tatcctcaaa atcacctttt tcagatatta atcttatcaa
    12901 tttaacagta cagcttaaat catttataag tatagctcca actaatgaac catctttcat
    12961 aaataatttt ttatatattc tttgaccttc atcttttgat gaaatttctt tatcaaaatt
    13021 ttgtatatta ccaatactaa atacttttac attcattgca tctaatgaaa ctggatatac
    13081 ttcactttca aatgtcaaat tatctccact tgcatttgcc cctgctattt ttcccatttc
    13141 tactgaagat ggccatattg ctaaactaat atttcccact tgtgcaacat ctccacaagc
    13201 atatatatct ttaacatttg tctgtaatgt cttatctaca acaatacctc tatcaatttt
    13261 tacagatgta tcctgaacca tttgagtgtt tgctcttaca ccaattgaaa atactaccat
    13321 atcacagtcg acactatctc catctttaaa tacaactttt tgagcttttc catcaccttc
    13381 aataccatca actgctacac ccaatcttac atctattcct gtatctctta cacattgttc
    13441 taatatttta ctaccttctt tatcaagttg ttttgatagt atgctatcca tggcttcaac
    13501 tactactact tctaatcctt ttagtctaaa ttcccatgca gcttcaagtc ccaataaacc
    13561 gccaccaatc actacaactt tcttagattt ttctagtgct tcttttacac tatataaatc
    13621 ttttatattt ctaagagtaa acacattttc taaatcatgg cccttaattg gtggtataaa
    13681 gtttctactt cctgtagcta ttacaagctt atcaaattta atagctccat cattcactat
    13741 aatagtttta ttcacttcat ctaatttatc tacattcgtt cctaatatta ctactatatt
    13801 atttttatca taccaatctt tatcttccat gtagaaatct gaaccaagtt cttcatttat
    13861 accatcagaa agtgcaggtc tatagtaagt caactcatct tcattagaaa tcatagttat
    13921 cttacaagtt ttatttcttt ttcttatagc atctgctgca taaaaaccag ctgctccatt
    13981 tcctactatt acgaaatatt catcagtatc ttttctaaaa gtaacttcat cttcttcaac
    14041 ttctataaat tggtcttcct tagctccaca tacagggcat acactaggag cactatcacc
    14101 ttcaaaaact tcattacaaa ttacacattt aaatttctta gttttctttt tacttccaaa
    14161 agtagaattt aacttatcta ggaatttacc tgtataagaa tataatttat caatctcttc
    14221 atttgatggt ttaaagttaa cagcaaaagg ttttactgct gtcattctaa gctgacttat
    14281 tctctccata gcattttcta taccttctcc actccatcca tatgaaccaa atactgaagc
    14341 aacttttcca ccatgaagaa ctgggtttaa cgatattaat atatcccata taggctttaa
    14401 cgcatctcct aatattgttg gtgttccaaa taatacacct tgtgatactg ctatttttgc
    14461 caaaatatct tcttgcttat gctctattac atcaaataaa tttactttat agttgctatt
    14521 tttttcaata tatgctttta tagcttctgc cataatcttt gtatatccat gtgcagaaac
    14581 ataacaaatt gtaacttctt tttctaactt tatttgttca tttacactcc agttgtaata
    14641 aaggtctata atttttctag gattttcagt taatactgga ccatgacctg gacatacagt
    14701 atctatatct aaatctttta tcttttctat agcagttacc atagatggtt taaatggacc
    14761 cattatacaa tcataatagt atcttaaagc atccaagtaa tccttttctt cattttcatc
    14821 aagtgtattt actatcttat cattactata gtgactacca aatgaatcac atgttacaag
    14881 agttttatcc tcttttatat atgtgtatat ggtatctggc caatgaagca taggtacaga
    14941 gaaaaattct aaagttttgt ccccaattga taatgtatct ccatctgtaa ctgcaacata
    15001 ttcaaagtct ttgtttacga tttccttaag atatttaatt gctgtttctg aagctactac
    15061 ttttgcattt ttagctaaat ccaaaagctt ttcaacgctt cctgcatggt ctggttcagt
    15121 atgacttaca acaatatagt ctattttttc aaaatctata tttaaatcat ttaatctttc
    15181 aatataattg tcaaaatgct tatctttaac tgtctcaaat aaaactgttt tttctgttcc
    15241 ttttaataca tatgaattat aagtagttcc ataaggtgta tacataatta tgtcaaatac
    15301 tcttaaatca gggtcaagcg aacctaccca atataaattt tcttttattt ttagtgattt
    15361 caatgacata ccgtactcct cctaaaatag ttatttagtc tctttatacc ctgcttgtta
    15421 tattttaaac aaaatttatt caaaaaagaa attattttaa agatagttta aatcttctaa
    15481 tcttcttttt ctaccttcaa tacagttccc tttttagaat ctacttttat gtcatattca
    15541 tttttatctt tatctattct tattttataa aaagtaacat ctaaatcttt gtctaaactc
    15601 cattctttaa ctattccatt ttgttctttt aatgcaattt ccatagcttg ttgaggtgtc
    15661 attatgtcat ttaaatctaa tttttctttt ctagcaactc catttaaatc ttctgaatcc
    15721 aacttttctg ttttatcttc taatacatct tttgtattag catcaatttt catcttatat
    15781 tcattattat catctacacc ttccacagta taaacaaatt tatttaaatc tctctcaaga
    15841 cttaaatcta ctatatcagc atccttatat ttatctttaa atatgtttat tgcatctgtg
    15901 tatggcactt taaaatcttg ttccattaaa ttttcattat ttttttcatc ttttaaagcg
    15961 ttatttgatg catttgcctc cttttttgta ttatcttgtg cttgtcctga atccttagtt
    16021 ggactcccac tacatgcagt taataaaccc gctataagca tacttaccac taataaatac
    16081 gtttttttac acataaaaac cctccttaaa tatattaatt tattctatat tatgccctct
    16141 aaacccttta tttacccttt tatattaaaa attcctccta ttttatcaat tttaaaactt
    16201 tatatttact aaaattaaag ttacataaaa attatactgt ctcaaaatgg aaacaagcct
    16261 ctttttcatt gttgaaataa taaaaatata ttttatttcg tacaaaaaga gtgcctcatg
    16321 aactaaaaag ttcattttga gacactccca tttttttata tttttactta caaaataaca
    16381 gtacttatta attttttaca aaccttataa gtatatctat atgatattct taaatttaaa
    16441 cactatatta aaaaattaaa ttttgtttaa ttcttttacc gttaaatcca ttttaggata
    16501 tggaatcgta attccttctt cgtcaaacct aactttaacc tcttctagta aatcaagata
    16561 aattgtccaa taatcttctg tcttgcacca aactctagtt gcaaatttaa tagcattatc
    16621 tccatgttct actactccta taaatggttc tggttcattt attattaatt tatgattatt
    16681 aacaatatct ttaagtactc ttctaacatg tagtatatca tcttcatacc ctacactaaa
    16741 agtcaaatca actcgtctag tattctttgc tgaatagttt attagactat catttgatac
    16801 agaaccatta ggtataagta tctgtttatt atctggagta accaattgtg tataaaaaag
    16861 acctatttgt tcaaccgttc ctccatgacc tgctgcttct acgtaatctc ctactttaaa
    16921 aggtctaatc aatagtataa taaatcctcc agcaaaattt gatagactac cttgtaaagc
    16981 caaacctatt gctacccctg ctgatgctat cacagcagca aaactggaca aactcattcc
    17041 ccaatattcc agaacaatga ttataacggc aactttaagt acactcaaaa gaagagactt
    17101 taaaaacttt cttaaagtta aatcaatatc tcttttacta agtaataaca taacatggtt
    17161 tacaaatttt tttattattt taaatccaat agaaagtata agtatgccta ttataagttt
    17221 tactccgctt gtagtagccc attctagcag actttccatt atacctccca tatccatctt
    17281 attaatatct aaattattta aatctaactt gcttatatca tctattttcg tcgtatccat
    17341 aaaaaactcc ttaccttata ttttagaacc aatattatag tttaaagttc ttattttcta
    17401 tttaatataa tacaatacca tttgtacata gtaaacaaga tttatattcc aattatacat
    17461 attaggaaaa tgcaaactat ttgttatata tatgcaaaat ataatactaa attaaactat
    17521 taataaaaca ctatatagcc ttaaaatcat cattttttac ccctatatga gatgatacta
    17581 tagttataat acttagtact ataaatacta caaaaccttt tttatatcca tcaactatat
    17641 tatatgaatt tacttgtaaa gagatagcta taatcaaatt aataattcca cttcctataa
    17701 attcaaaagt attaataaca ctagttgcca gtccagaata aatttcttta tttttatact
    17761 tggcatcatt aaaaacctgt agatgtgaca taactataca tcccataata aagaatgata
    17821 ttggtaaaac tataattggt ggttttacct ggtatacaac tacaattaca atccatataa
    17881 acaaatctat cattgctcca aattttatta tattaaattt gctagacctt attttagcaa
    17941 atacaaaatc cataattatt gaaccaaata taaatccata tgtaaaaaat gatactataa
    18001 acgcagaaaa actcttactc acaccataaa cgtccattat gtatcttact ccccacaagc
    18061 ttataaatgc acttgtaaga ccaacaaaag agaacattat cattgaatta taccatgttg
    18121 atttgttctt tataacagac ttaataccat caacaatatt aaccttctct gacttttcat
    18181 agggttcagt atctacattg aatccatact cttttggtgt atctctaaca ataatataca
    18241 taaaacatcc aattacaaca ccaattatac cgattaataa aaatgaattt ctccaaccaa
    18301 caagttcaga caaaaacaca agtggaaaag tagcaagaac tccacctaaa tttcctacaa
    18361 atgaaaattt agctgttgca gaagcaaatt ctgacttatt aaaccatctc ccttgaattt
    18421 ttaaaataca aagtaatatt actgatgttc ctgcccctac aattacacga gaaatatatg
    18481 ctaattctat actttgaatc aaaccaaata aaattgaccc taaacttgcc attattattc
    18541 caagactgct aatttttctt gctccatatt tatcaatcaa aattcctgca ggtatttgca
    18601 taaatgcata tgcatatagg caaaaggatg ctatatttga aatttgtata gaattaaaac
    18661 ctaactcatt tgctaaattg tctgaaacaa cagcagttga catccttaaa aataatacta
    18721 aaacaaatga aaatgtaatt ataccccaaa cactccactt agcctttgta taacttttca
    18781 tatcttctcc ctcaaatcca tatattttta aattttcttg atataactta tataaagtgt
    18841 atagttattc ttacaaattt ttacacgcaa tatcattata caacatatgt atatatttaa
    18901 ctagaaataa aacactattc atattatata catgaattaa ctacataaat aataagagcc
    18961 atcttttaac attactcaaa agatagctcc atataaaaac atttattcta aatttaattt
    19021 tttatctaat ataaattttg tagcgaaaaa taacgctatt gcaactacaa gactaccaag
    19081 tattgcaagc ataaaactag gactctgata aagatgatat accatatttg tatcttcatt
    19141 tggtaagatg cttccaactg catctccaac aattgatatt actatattta tagctataaa
    19201 agaagcaaat gccactatgt ttctatgttt attgaatttt ggcaattgtc ccattgagat
    19261 tgatgtatat aataacaaaa taaatgatga atatgaaata aacattacta ctactaataa
    19321 taaaatatct aaaaagtttt cagaaatcca tttaaaacta gtgttaaaca aatctaaaat
    19381 ttcaggtagt aaaattccag aagtaccaaa aagcataaga actccaaaag tgaatactgc
    19441 aactataaaa ctaagtacag cgtatataag tgctgttata catttagata atataagtga
    19501 actagtgcta acaggaagag taaacattaa ataaccttca tcccccaaaa gattttttct
    19561 aaacctttga attgtaacta caatagttaa aactcctaat gccataaaaa gacttgttaa
    19621 tactagtatt cctattccct gtacctgaag tatatttgta ttcataaata ttccattaaa
    19681 tacagctact atcaatatgg ctatatataa cggtataaat attcttccac ttgcttttaa
    19741 ctcatatttt aataatttac ctaacattta aattcctccc taaataatgc atctatagat
    19801 tttccttttt cttctcttat tgcttcaacg tctccttgta acactatttc tccttttgat
    19861 atgaatatta tctcatcaca tatgttttct atttcactta ttaagtgggt agcaatcagt
    19921 aaagtactat cttcagaata attttttaat atagtcttaa gtatatatga ccttgcagct
    19981 gggtcaacac cacctatagg ttcatccaat atatatatgc tcgcatttct tgacattact
    20041 aaaataagtt gaactttttc tttagttcct ttagacattg tctttagctt ttcatttaca
    20101 tcaatatcta agcttttaat catctcattt gctcttctaa catcaaaatc actataaaaa
    20161 tcatagaaaa acttaagtaa atctgatacc ttcatccaat catttaaata agttctttct
    20221 ggtaaatatg aaactatttt tttagtatct atggatggtt tcattccatt tatcataatt
    20281 tcaccattat caggctgtaa taatccattc attagcttaa tcattgtact tttgccactt
    20341 ccattaggtc ctaacagccc gactattttt ccctttggta tatttaaatc aatatttttt
    20401 aaaacattct tagttccata actcttgttt acacctttaa attcaactat tccatcttga
    20461 gaaacattgc ttatattttt atccatttta taattctcct ttcagatttt ctgtaataag
    20521 ttttagcatt tcatctctat catatccaag cttttctaag gttactttta atgtatttat
    20581 ctccacatta gctatttcct ctttcatagc ttttattttt tccttatcat ctgttacaaa
    20641 tcttccttta gttctctgac tataaactaa accttgtctt tcaagttctg ttagagcctt
    20701 ttgcattgta tttggattaa cttccgcatc ttctgctagt gctctcactg tttctaattt
    20761 agatcctatt ttaatttccc ctgaaattat ttttaacttt aaatgttcta ctaattgtat
    20821 atatataggt ttgttattat caagttccca ttccatgttc atgcctcctt attatattat
    20881 tgtattaagt tgttaataca ataatataat aatacaaagt atatgtcaat tactttttag
    20941 taaaagtata aaaaatttta caaaaaaaat gaacactaca ttagagtcca tttttaacac
    21001 aatttattaa attctttata ttacagatta attaccctct taccaagtta gatacaatta
    21061 aatgttcaaa ttcttcaatt ggcattggct ttccaaacaa atatccttgt gccatatcac
    21121 actttacttc ttttaaaagt ttaaactgtt cttctgtctc aactccttct gatatgactt
    21181 tcatacccaa ctcttttgcc atttctatta ctttagtaac aattattttg cttcttttac
    21241 tattataagt ttccataata aatttttggt caagttttaa gatatccata ggaatttctt
    21301 ttaacatatt taatgatgag taccctgaac caaaatcatc catagatatt aaaaatccta
    21361 ttttttttaa attattcatt atatcaatta aaatatcaaa attatcaaat atgatactct
    21421 ccgttaattc aagttctata tactttgcag gtatattgta tttatcaatt atatttttgt
    21481 atgtttctat aaaattattg caatataaat gtatccttga aacattaact gaaacagtaa
    21541 ctggatttat tcctgcatca atccattttc taaggtatat acatacttct tcaagcacat
    21601 ataaatctaa atttataaca aaaccgtttc tttcaaaaaa tgggataaat tcatttggag
    21661 gtattagccc tttatcagga cgtttccacc taacaagtgc ttctgaacct tgtatctctc
    21721 ctgtattaag ttctatctta ggttgtaagt atataataaa ttctttattt tctagacttg
    21781 aaaacattgt attttccatc tctttttctt ttatctcttg gtcatgaatc ttattatcat
    21841 aaaatgcata tgaactttta tgtcctccct ttgccatttt atgaggtata ttagccctat
    21901 ctatgattga gttgatatct ctatcttctg gaagtataaa atagattcca caacttaaaa
    21961 ctaacttata tttttcttct tgattattat taaacaagtc taattcttca aatatagttt
    22021 ttaacctctt tgttatatct tcttcttcta tatatttcat aattataata aaattatccg
    22081 cagatattct tgcaaacatt tcctcttcaa atatattgct cttaataatc tttgttaaat
    22141 tacgcaaaat ttcattccca acttcatatc caaataaatc atttatatat ttaaatttat
    22201 caatatctat atataataaa gcatacttta cttgagtatt tttacatagt attttgttag
    22261 catcaattac aaatttatct atagtatttg ctcctgtaag attatctgta tatgctatcc
    22321 tttgcaattt aattttaaaa tttaatttat catatattat atagaatata agtattacac
    22381 atattatagc cataataagt attatttgta ttgcatgttt gctaataagc tgattattag
    22441 acacaataga ctcaaagtta tttatggagt tgtttttata gagtttgcat aaagaataga
    22501 ctggtgttgt gtatgtaatt tgtaaaatta tacaaataaa taaaaaaaac atcaattttt
    22561 tttgtaaatt cctcataaaa atttcctccc attaaaacac ctctatttta ttagcaaata
    22621 agtacatctc aaaagtttcc atttcttgta aaatggatag ttttgaaaag aaaatattaa
    22681 aattataata taaaaataaa atttttcaga caatttaaac aaaaataatc accttttaat
    22741 aaataattat atgccaaaat aatccaattt attttctatt atacctatat gaaatatata
    22801 aatcaatagt taagacaatg aatatgctac attctataat tata
//
LOCUS       DAEHWM010000067        22592 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.068, whole genome shotgun sequence.
ACCESSION   DAEHWM010000067 DAEHWM010000000
VERSION     DAEHWM010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22592)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22592)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22592
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.068"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(104..250)
                     /locus_tag="KNP36_002545"
     CDS             complement(104..250)
                     /locus_tag="KNP36_002545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874406.1"
                     /translation="MVFETFDKTIELYPNAKPIFHSDIGFRLDDESFEEYLGRVFRKR
                     CKGI"
     gene            283..669
                     /locus_tag="KNP36_002546"
     CDS             283..669
                     /locus_tag="KNP36_002546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874407.1"
                     /translation="MNNNKFVAPNNVTLVERCYRYIKDRECSFSPNTIRNRKNMIKNQ
                     IEVFFKDMKLIDITPSILQSYINNIYNEHMLNSIKNQVDFIKSVLKESYRLKEISENI
                     CDFVTTPIKKVVQLLSFIQNKKLNYY"
     gene            1536..2891
                     /locus_tag="KNP36_002547"
     CDS             1536..2891
                     /locus_tag="KNP36_002547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0874408.1"
                     /translation="MDTKISINENMSLGKRFFKYLAPSVVAMWVFSLYTMVDGIFVSK
                     GVGELALAAVNISMPFINFIFAVSLLFSTGASTIIAIYLGKKDIKSANEVFSFNLVSI
                     IILSIIILAITFFNLDRLALFLGATESTIGMVKDYLGIIIFFNGFFIVSYSLEVIIKT
                     DGFPILATVGVIISALTNIILDYLFVIEFGWGVKGAGIATGLSQVFSTIFFLIHFLRK
                     NSTLNFSKFRIDFKTLRKIVFIGFPDSTTELSCGIVVLLFNLSLTKYIGENALIYYSV
                     INYINTLVLMTMMGITQGMQPLTSFYYGAGNIDNVKKLLKMGIKATIIASVAVFAICM
                     AFSGPIVSLFIHPEETMLFNEGVRVFKIFSISFLLVGINVIISGFFVSVEKPSISTVI
                     SLGRGLVIVVLSLISMILIFGGQGIWMTTIVSEFICLILSLVFLKKNFSTLDSNLNKV
                     A"
     gene            complement(3009..3677)
                     /locus_tag="KNP36_002548"
     CDS             complement(3009..3677)
                     /locus_tag="KNP36_002548"
                     /EC_number="6.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphthine--ammonia ligase"
                     /protein_id="HBF0874409.1"
                     /translation="MKEVLKLADEKFVMSFSGGKDSILALNRMLKKGYKPVALLTTIS
                     EEHGKSWTHNLEYNMLKQVSSNIGLPLLVAECGVEGYEESFERALIKAKNMGATICAY
                     GDIDIESHRKWDTDRCEAVGMKVDLPLWQESREELVYEFIDSGFCSVVTKVNLKHLGE
                     EFLGKKLTRELVEKIKNAGADPCGEHGEYHTFVVDGPIFKKPVEYEVKGTLIKDGYGY
                     LEIK"
     gene            complement(3744..4172)
                     /locus_tag="KNP36_002549"
     CDS             complement(3744..4172)
                     /locus_tag="KNP36_002549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HBF0874410.1"
                     /translation="MTKLWAIIFALLAGGSTALEAFINGELGKSTTALVATFISLTVG
                     AIFFLASIIVTGDLKCLVSINGFNYKLLLGGVFGGLIIYFTVKAIPNLGVSNTLILTL
                     VSQVLVGFFIDSVILGQETMHLYKYIGVILLILGTFFIVN"
     gene            4279..4872
                     /locus_tag="KNP36_002550"
     CDS             4279..4872
                     /locus_tag="KNP36_002550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF308 domain-containing protein"
                     /protein_id="HBF0874411.1"
                     /translation="MNFCYNCSIDFGGDFMYTNFNIDFNNFNKKENAIKFMLMGVLLI
                     ILGLLCLTFKTLGIKLISWTFGIALLFFAYLNLKNINELKRYATKEEIKPSINIQWVL
                     IIACILLFVFPQKIQSIFSLFLGFYLIFNQLVALVNSKNNPYSKFTTWNIVKILFGIC
                     LILSPLFLSRFIVSIMSFFIILFGLVLFFSGNTARKY"
     gene            4991..5926
                     /locus_tag="KNP36_002551"
     CDS             4991..5926
                     /locus_tag="KNP36_002551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893027.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
                     /protein_id="HBF0874412.1"
                     /translation="MDKFKYAFDNKRYHTWNYYLRNTFGEKVFKVSINAGFTCPNIDG
                     SLGYGGCTYCSKEGSGDFAGNPKDNLISQFYNIKEMMLKKWPHAKYIGYFQAYTNTYA
                     PLEVLKEKYETILELEDVIGLSISTRPDCLPDDVVEYLSELNKRTNLWVELGLQTIHD
                     STSKIINRGHDYKTFVEGVEKLKSKNIKVVVHIINGLPGEDYNMMMETAKAVGKMGVD
                     GIKIHLLHVIKDTPMEKMLQNGMLTLMEQDEYINLVCDQLEILPETMIIHRLTGDGKR
                     DELVGPIWSLKKWEILNKIDDTLKARNSYQGCKFV"
     gene            complement(6197..7141)
                     /locus_tag="KNP36_002552"
     CDS             complement(6197..7141)
                     /locus_tag="KNP36_002552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HBF0874413.1"
                     /translation="MGEKSKGYVFIAIAGLLWATLGLFGKFLMGNGLTSEQVAFTRLF
                     FGFIVLGVYSSIRTPQILKINKKGIIYSVIIGIICQAMFNLCYFKAIDIAGVSIAAVL
                     LYTSPLFLAIFSKLCYKENITRSKLFSLILCFIGAIMAVTGGRLDFQGLNAFGLLLGV
                     LSAIAYALMPTISKNALKEFSSSTILVYSFLFGAIFMIPSSRPWEILNYAKDLDVLSC
                     MLMLGIVPAALAYIFYAAGISKGVELSVAGVVASVELVGSVIIGCTILGESFSLGKLF
                     GVMLMLISAVVALNLSYDEIRIFYKSNKLKQIEKTESI"
     gene            7459..8889
                     /locus_tag="KNP36_002553"
     CDS             7459..8889
                     /locus_tag="KNP36_002553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0874414.1"
                     /translation="MNLDLEFYQKILEASHDEICVSDDKGIIIYCNKAFEENYGLKKE
                     DILGKNVSFLEDSGYSTKSPIPIVLKTKTKFSLEQDTQTGKKLIITATPIFDENGHLE
                     FTVENCRDITELNNIKNKLEDTKKQVKKYKSEVETLYRTALRIEDTVIMDGIVMRPII
                     NTVNHVSKTDVSVLLLGESGTGKSSLARYIHHNSNRSNGPFITINCATISPQLLESEL
                     FGYTSGAFTGASTKGKVGLVELANGGTLFLDEIGDIPQNLQAKFLQLIQDRTFTPVGS
                     LKNKKVDIRIISATNVDLVSKVKEKKFREDLYYRLNVIEIKLPPLRERRDNLVEIIKY
                     YFNRYSSDFNLNKTISKEAMDAIANYRFPGNIRELQNIIQKILLTCTDNHITIDDLPN
                     ILTKNIHITNNGNKTHISQINKVIISDSKSTNYKNKNFDTLIKEYEKNIILDAYEKFG
                     SSYKVAKHLEISQSKANRLIRKYTNT"
     gene            9089..9673
                     /locus_tag="KNP36_002554"
     CDS             9089..9673
                     /locus_tag="KNP36_002554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc dependent phospholipase C family protein"
                     /protein_id="HBF0874415.1"
                     /translation="MLMNTHFIMAKSILDNIDENKTFFISEKNFIYGNIKPDAFSKYK
                     LKKHYLDESFNMIVSKINYLCSLNIDSLSKYFSVSRLSQELGVICHFLCDFFCVAHSE
                     RWEFKHSLNKHVTYERELGAFAKDVDLSKIKCGTINSSFEKFFTKLYSDYKKKTDYMN
                     DLKFSAYTCNSVINYILDSILSNTIKSYHIANCG"
     gene            complement(9777..10556)
                     /locus_tag="KNP36_002555"
     CDS             complement(9777..10556)
                     /locus_tag="KNP36_002555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBF0874416.1"
                     /translation="MIKHIFCDLDGTLYENGTITKEDIVAIEEIEKKGVQFNVATGRI
                     FKQAHNIIKDSLDMNGYYVCENGSFIYDKDYNVIFKRTIDDNLVKKVIDRFESSDAQL
                     YFKYKGDVIVGSDTTAFRHYSSDFIVDPDFEKRSSFDNLIGNIGVCSENLEELSRIEL
                     YLKSEFSEVLEIYFSGTYTLNIVPKSVSKRGSIEHVIKTLNVSPDEVATIGDSPNDIC
                     MLEGFKYSFAMSKAREDVKQSANYVVDSVKSAIDVIMEINS"
     gene            complement(10614..11870)
                     /locus_tag="KNP36_002556"
     CDS             complement(10614..11870)
                     /locus_tag="KNP36_002556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011591286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HBF0874417.1"
                     /translation="MKAEIISVGTEILLGDIVNTNSQFLAKELASLGIEVYHQSTVGD
                     NKQRLLECFDESLKRSDFVITTGGLGPTGDDMTKETAAEYFGQKLELHKPSLEVLESF
                     FVKTGKKMAENNMKQVYFPKDAIVLKNNNGTAPGAILKKDGKFIIVLPGPPREMKAMF
                     NESVKPYLQQFTNEMLVSKTLRLYGIGESNLELEILDIINEQTNPTVALYAKELEVTI
                     RITAKAENEREAFKLIKPVEEKIKSRVGKYVYTEGDISISEGETALEDAVSKLLVEKN
                     LTIAVAESCTGGLVSSSLINYPGISSVFLEGCVTYSNDSKMKRLGVKRETLEEFGAVS
                     EQTAIEMAEGIAKGLKANIGISTTGVAGPGGGTKEKPVGLVYTAIYINGKTIVKKNIF
                     NGDRRKIRLRATRDLLNELRIQLEKL"
     gene            12128..13027
                     /locus_tag="KNP36_002557"
     CDS             12128..13027
                     /locus_tag="KNP36_002557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HBF0874418.1"
                     /translation="MKIAVIMGGISSEREVSLNSGKEIYNNLDKNKYEVVKVIIDDKK
                     DIFTKIPEDIDFAILALHGKFGEDGCIQSILETMDIPYSGCGPLCSGMCMDKNITKKM
                     LRDSNLPTAPWVLVKSVDEIDYDEIDNIGYPVFIKPNSGGSSVATFFIHSKDEVEEAV
                     RKGLEVDEFVMIEKYIPGGEYTSFILNGEVFPTISIKSDSGFFDYEAKYSVEKGAKEE
                     VVYLDEELQKRVNEISETCWKIFNCKAYVRVDMIISEGIPYVLELNTLPGMTQTSLIP
                     RSAAARGIKYSELLDKLIEYSLN"
     gene            13051..14499
                     /gene="ddlR"
                     /locus_tag="KNP36_002558"
     CDS             13051..14499
                     /gene="ddlR"
                     /locus_tag="KNP36_002558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator DdlR"
                     /protein_id="HBF0874419.1"
                     /translation="MIFSNLKLNDNEPIYIQLKNYISDMISKGLIPDNSKLPSTRELS
                     QLLQVSRNSVVLTYEELKSEGLIYSISGKGTFVKSKNKSSNTTWSLNWDCLENTYSKK
                     ANELDIIKSEIPWSSDLISFKSISPDGDLFDMEELKKSFLNRISLEGHKLLNYGYAQG
                     YKPLIDYLLEYMTNKGADISNKDILITNGFTEGFDIIMSSFTQEKDYIICENPTHNTA
                     IKIMKSHNLNILGVDINEDGLDFNMLEDNLVKYKNKIKFAYITPSYHNPTGIVMTPEN
                     RYKFYNLMKKYNIAIIEDGFNEELLYNSSHIFPICSLDNMNNGVVYIGSFSKILFPGM
                     RIGWIFADKKVINKLESVKRCRNIHVSFLDQGILFDYLSNGGFEKYIKKIRKFYGDKF
                     NFAYKCIKKYIKTEYILGDGGLHIFIKLKNIDTRVLLEKCYEKNVIFMPGDLFFTDNS
                     GFDTLRLGFSRLSFEDIEIGIKIIGETINEMF"
     gene            14558..15364
                     /locus_tag="KNP36_002559"
     CDS             14558..15364
                     /locus_tag="KNP36_002559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBF0874420.1"
                     /translation="MNLILGDNMSKKSKRRKINKLKLTIVITVLFLALLSIYEILFSN
                     PNKKGNIKSQETMQNKNNTTDDSKNNQSSTKKQEDNNIKPTFSYSSIPDNIKNKMIGK
                     SMPTDEPISFDSLSYLKLTYYGFDEKTHQGEMIVNSELAPEVVDIFKELYEKKYPIEK
                     IKLIDDYDAVDEKSMSDNNTSSFCYRTIAGTNVVSNHGKGRAIDINPLQNPQVSGNDV
                     TPKVSTVYADRSSTKFGMIKKGDDCYNAFVSRGWSWGGYWKNPDYQHFEK"
     gene            15390..17309
                     /locus_tag="KNP36_002560"
     CDS             15390..17309
                     /locus_tag="KNP36_002560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_071223118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HBF0874421.1"
                     /translation="MNLMTLENISKSYSEKKLLENISLGINEGEKIGFIGVNGTGKST
                     LLKIIAGVEESETGNITKTNGIRIEYLPQNPTYNENSTVLEQVFNGTSEELKLLGEYQ
                     EILEKLNSNFTEELNKKLLSVHEKIDALNLWDLESEAKSVLTKLGINDFNQKIAELSG
                     GQRKRVSLASALITPCEFLILDEPTNHLDNDTIDWLEEYLNSRKGSLLMITHDRYFLD
                     RVTNRIIELDKGRLFSYDGNYSIFLEKKMERLSLEASIEDKRQNLIRTELAWVRRGAQ
                     ARSTKQKARLQRFDELINRDSFKPDENLDISVASSRLGNKIIEIHNISKSFEENTVID
                     NLEYTLTRTDRIGIIGKNGMGKSTLINILNGEIEPDSGYISIGETVKIGCFSQDDSHM
                     NIDMRAIDYVKEASDYIETSDGTRITASQMCERFLFNGTMQYTLIGKLSGGERRRLHL
                     LKILMTAPNVLLLDEPTNDLDIETLKILEEYLDEFKGVVVTVSHDRYFLDRICNKIFA
                     YEGNGKIHIYTGNYSDYLIYREIQGIEFEESKRESVKKDDSTTPKKEKPKNDKKLKFS
                     YNEQREFENIDSDIEKLESKIATLDESTAKFSTDFTKLQEILDEKSKLEKELEYKYER
                     WEYLNNLADEIANNK"
     gene            complement(17551..17898)
                     /locus_tag="KNP36_002561"
     CDS             complement(17551..17898)
                     /locus_tag="KNP36_002561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PqqD family protein"
                     /protein_id="HBF0874422.1"
                     /translation="MSKSNDVLDIVFKITDGLEYEVAENRVVTILEKQDHKIQKFFRK
                     LKARIPKYKKIELDEYSSFVFLQIDGQRTVREIGKNLEAKYGEESHPLYERLLVFLNH
                     IEVNCHYIERLDI"
     gene            complement(17885..19813)
                     /locus_tag="KNP36_002562"
     CDS             complement(17885..19813)
                     /locus_tag="KNP36_002562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide transporter, OPT family"
                     /protein_id="HBF0874423.1"
                     /translation="MNKKLPKGAYGEVSGKDYVPYITDKSRTGGNVAVLIIGIILAAI
                     FAASTTYSGMKAGLTVAAGIPGAIIGSAFVGAFARSKGILGKNLIQGMSSGGESVASG
                     FIFVLPAVILIGSQITFLEGLAVGVGGVLFGIGIAAIVHNYLIVEEHGKLMYPESMAI
                     SETLVASEAGGDSIKYMGIGFVISGFITVLTGSFLNVANNVMSLVGSKFYKWKFDIEV
                     NPLLLGIGFIVGLEVSLTMFAGSILSNFGIAPLIGYFTDMAKDGAMVWNNPAMPLNQM
                     DVGAISSSYVKYIGAGMMLCGGIIGAIKLIPTIIASIKETLKAKSSAGEGEEGSSIQM
                     ILLLGGVVIGFLAAFLISGNIVMAIIGAIISLLLSLLFVIVAGRLTGTIGTSNLPVSG
                     MTIASLVIVTLVFVIMGWTDLEANKSLLLFGSFIVVAIAIAGGYTQSQKVTYIIGGSK
                     NEMQRYFTIASIVGVIVVVGVILLLSDQLRATGDNVQFALPQANLMSTLTSGIMSGSL
                     PWVMIIVGVFMAIVLYALNLPIMTIAIGFYLPIATTSIILVGALIRLFVELVSKTEKE
                     KEVKVSNGISLSSGLVAGGSIIGLIGIILQVTGVVTPKVPSGFAATNSMAIALLVVLV
                     VLTALPIVLSKVKNNEQE"
     gene            complement(20225..22414)
                     /locus_tag="KNP36_002563"
     CDS             complement(20225..22414)
                     /locus_tag="KNP36_002563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid adenylation domain-containing
                     protein"
                     /protein_id="HBF0874424.1"
                     /translation="MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVF
                     KMNIEKHERLIQYSKVNNISIDSIIETIYGLILQKYIYEDDVVFGKTMNIIPIRVRVR
                     QSEKFIDVVRKLKRQWSRSLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDI
                     EKKGYDLSVIVYTKRALKIKIKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDL
                     EFVCKEEEKVLLEDFNNNQYEVPYDKSYVDLFREQVKVTPSNIAARDENRKLTYKELD
                     EVTDKLAGYLNHIGVESEDIVAVMLPRDINIIITAIGIMKSGGAFFPIDTSNPEERLN
                     YLLEDSNAKVVITTDELKSKVVNENTIVLDINDEEMFKFGYELTEKITSSNCAYTIST
                     SGSTGRPKTIAIEHKSLVNMCYYSVKSISATENDICGIYLSFSFDAVMKQLFPYLLVG
                     ASIDIMPEEAKFDEYTVNEYCEENDITILALPTAFARLFIQNCNNNSLRVVQTGGERL
                     KGYRKRNYELYNEYGPTEFTVVSTSFHVDREYGKIPIGKPIFNTYAYVLDKKNKLCPI
                     GAPGELCLSGIQISRGYLNKKGLTEQVFVENPYKTCEHNKLMYRTGDLVRWLDDGNLD
                     YIGRMDNQVKIDEFRIELYEIENIINNITEIKSVVCISRTNDDGDIYICAYYVIDEED
                     SGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIGKVNKRALPE"
BASE COUNT         8297 a         3347 c         2867 g         8081 t
ORIGIN      
        1 tatattatat gattttatcg catcttctat tgagatattt aaacatatat ttactgcttc
       61 ataaaaatca aattcattaa aaaatccatt tttatttaca atcttatatc cctttgcatc
      121 tctttctaaa tactcttcct aaatactctt caaaactttc atcatctaat ctaaatccta
      181 tatcactatg aaaaataggt tttgcatttg gatatagttc tattgtttta tcaaaagttt
      241 cgaataccaa gttattatta ttcgattttc caatagtcca ctataaacaa taataagttt
      301 gttgctccaa ataatgtaac acttgtagaa agatgttaca gatatataaa agatagagaa
      361 tgtagttttt ctcctaatac tattagaaat agaaaaaata tgattaaaaa tcaaattgaa
      421 gttttcttta aagatatgaa attaatagat ataacacctt ctattttaca gtcttatata
      481 aataacatat acaatgagca catgttaaat tcaataaaaa accaagtcga ttttataaaa
      541 tcagtattga aagaatctta tagattaaaa gaaatatcag aaaatatttg tgattttgtt
      601 acaaccccaa tcaaaaaagt agttcaactt ctaagcttta tacaaaacaa aaagctcaat
      661 tattattaga aaaatcaaaa aatattccta taggtatacc aatttttttg atgctaactc
      721 ttggattacg ttttggtgaa gctgtatcac ttatatggtc agatgtagac cttgataaaa
      781 aatctcacat gtaaatcaaa cattagttta tgtatacaat aaaataatct tcaaagaccc
      841 taaaacccct atatcaaaaa gaaaattatt tgctcctgat gaacttataa gtttgcttaa
      901 aggggaaaaa ttaaaacaaa ataagttaaa attacagggt atattgaaaa atgaatttga
      961 tttgatatgc ttaaataaaa gattcaaccc gtgagttcaa ccaacttttg ttgttcattt
     1021 taaaaaacta ttaagagata ataatcctag agatataaaa gtacatgaat taatacatgc
     1081 aaatgcaact ttgatattac tttcaggtac taacataaaa gctatttata aaatattagt
     1141 acatgcagat ataaaaatag ctatgaatat atattccata ttctcactta ttagatgaaa
     1201 tgaataaaga aacatctgaa aatataagca aaatactatt caaataatgt tcagttttat
     1261 gtcaattaaa tgtcactcaa agtgcttttt tttcatttgt cagttaaatg tcacttaaag
     1321 tacctttttc ctatttgtca gttaaatgtc agtaatatat aaataagata tatttataag
     1381 acccttaaaa tcactattat ttaataaaat ttataattat atactatttg ctgttgacat
     1441 tggtattata ccatagttta tcatttatat tagaaataaa attattaatt aatagtttcg
     1501 taattttata atagatttac agggagtgat agtaaatgga tacaaaaata tctataaacg
     1561 aaaacatgag tctaggtaaa agatttttta aatacctagc accatctgta gttgcaatgt
     1621 gggttttctc actatataca atggttgatg gaatatttgt aagtaaagga gttggagaat
     1681 tagctttagc tgctgtcaat atatcaatgc cttttattaa ttttatattt gcagtttctc
     1741 tattattttc aactggtgca tctaccataa ttgcaatcta tctggggaaa aaagatatta
     1801 aatctgctaa cgaagtcttt tcatttaact tagtatcaat aattatatta tcaataatta
     1861 tattagctat aacttttttt aatttagata gattagcact atttttagga gctacagaat
     1921 ctacaattgg tatggttaaa gattatttag gaataataat attttttaac ggattcttta
     1981 tagtgtctta ttctttagaa gttataataa aaactgatgg ctttccaata ttagctactg
     2041 ttggtgtaat aatatctgct cttacaaaca tcatacttga ttacttgttt gtaattgaat
     2101 ttggatgggg tgtaaaaggt gctggtattg caactggttt gtctcaagtc ttttctacta
     2161 ttttcttctt aatacatttt ttaagaaaaa actctacttt gaatttttca aaatttagaa
     2221 ttgattttaa gacacttaga aaaattgtat ttataggttt tcctgattca actactgaat
     2281 taagttgtgg tatagttgtt ttacttttta acttaagtct tactaaatat attggagaaa
     2341 atgctcttat ttattatagt gtcataaatt atataaatac attagtactt atgactatga
     2401 tgggtataac tcaaggtatg caaccactta ctagctttta ttatggtgca ggaaatatag
     2461 ataatgtaaa aaaattatta aaaatgggga taaaagccac aataatagca tcagttgctg
     2521 tatttgcaat ttgtatggct ttttcaggac caatagtctc tttatttata catccagaag
     2581 aaacaatgct attcaatgaa ggagttcgtg tatttaaaat attctctata tctttcttat
     2641 tggtaggaat taatgtaata atttctggat tctttgtatc agtagaaaaa ccatcaattt
     2701 ctactgttat atctcttggt agagggcttg taatagttgt tttaagtcta atttcaatga
     2761 tactaatatt tggtggacaa ggaatatgga tgactactat tgtttctgag tttatatgtc
     2821 ttattttatc attagttttt ctaaaaaaga atttttctac attagactct aatctaaata
     2881 aggttgctta gatgataaga gtgacaatat atgaaaatat ctaaataaaa aatacctatt
     2941 atacaatctt gcaaatatta aacctttgca aaaattagga ttatataata ggtattttat
     3001 ttatgtaatt attttatttc taaatatcca tagccatctt ttattaaagt tccttttact
     3061 tcatattcta caggtttttt aaatattgga ccatctacga caaatgtatg atactctcca
     3121 tgttctccac atgggtctgc accagcattt tttatcttct ccacaagttc tctagttaat
     3181 ttttttccta aaaattcctc tcctaagtgc tttaagttta cttttgttac aacactacaa
     3241 aatccactgt ctataaattc atatactaac tcctctctac tctcttgcca taatggtaaa
     3301 tctactttca taccaactgc ttcacatcta tcagtatccc attttctatg actttctata
     3361 tctatatctc catatgcaca tatagttgct cccatgtttt tagcttttat taaagccctc
     3421 tcaaagctct cttcatatcc ttctacacca cactcagcaa ctaataaagg taatcctata
     3481 ttgctactta cttgcttaag catattatat tctaaattat gtgtccatga ctttccatgt
     3541 tcttcactta tagttgtcaa gagtgccaca ggcttatatc cttttttcaa cattcgattt
     3601 aatgctaata tactatcctt accaccacta aatgacatta caaatttttc atcagccaat
     3661 tttaacacct ctttcatcta actttgtttt attaacataa ttataccaaa tttttgagtt
     3721 gcatagcaaa ttatattaaa ttgttaattc actataaaga atgtccctaa tattaaaagt
     3781 ataaccccta tgtatttgta taaatgcatt gtttcttgtc ccaaaattac gctatcaata
     3841 aaaaatccaa ctaaaacttg ggatacaaga gttaatataa gtgtatttga tactcctaaa
     3901 tttggaattg cctttactgt aaaatatatt attagacctc caaatactcc tcctaataac
     3961 aacttataat taaaaccatt tatagatact agacacttta agtcacctgt aactattata
     4021 cttgccaaaa aaaatattgc tcctacagtt aagcttataa aggtggccac taatgctgtt
     4081 gtactttttc ctagctctcc atttataaaa gcttcaagag ctgtagaacc acctgctaat
     4141 aatgcaaata ttattgccca taattttgtc atggacaaac ctccttctat ataattctat
     4201 taatagaagt ttatgataca acctattaat taattactaa gtatagttta atttttatac
     4261 actaggcttt atttggatat gaatttctgt tataattgtt ctatcgattt tggaggtgat
     4321 tttatgtaca caaattttaa tatcgatttt aataacttta ataaaaaaga aaatgccatt
     4381 aaatttatgt taatgggagt attactcatt atattaggat tattatgcct tacatttaag
     4441 acattaggta taaaattaat ttcttggact tttggtattg cacttttatt ctttgcatat
     4501 ttaaatttaa aaaatattaa tgaactaaaa agatatgcta ctaaagaaga aattaaaccc
     4561 tctattaata tccaatgggt tctaataatt gcatgtatat tactttttgt atttcctcaa
     4621 aaaatacaaa gcatattttc attattttta ggattttatt taatctttaa tcaactagta
     4681 gcacttgtaa atagtaagaa taatccttat tctaaattta caacttggaa tatagttaag
     4741 attctatttg gtatatgcct tatattatct ccactttttt tatctagatt tatagtatcg
     4801 ataatgtctt ttttcataat attatttgga ctagttctat ttttctctgg aaatacagcg
     4861 agaaaatatt aattattttc tcgctgtatt tttatattac ttaaaataga atttgtttaa
     4921 gttatctatt tgtggtaata tgttttttgt acaagctcag cgtacaattt tattagaaat
     4981 aggtgatttt ttggataaat ttaaatatgc ttttgataat aaaagatatc atacttggaa
     5041 ttactatctt agaaatactt ttggagaaaa agtttttaag gtatctataa atgcaggatt
     5101 tacttgccca aacattgatg gaagtcttgg ttatggcgga tgtacctatt gtagcaaaga
     5161 aggctcaggt gattttgctg gaaaccctaa agataatctt atcagtcaat tttataatat
     5221 aaaagaaatg atgttaaaaa aatggcctca tgcaaagtat attggctact ttcaagccta
     5281 tacaaatacg tatgctcctc ttgaagtttt aaaagaaaaa tatgagacta tattagaact
     5341 tgaagatgtc ataggtcttt caatatccac aagacctgac tgtttgccag atgatgttgt
     5401 agaatacttg tctgaactaa ataaaagaac caatttatgg gttgaacttg gacttcaaac
     5461 aattcatgat tctacatcta aaattataaa tagaggtcat gattataaaa catttgttga
     5521 aggtgttgaa aaattaaagt ctaaaaatat aaaggttgtc gtacacatta taaatggtct
     5581 tcctggtgaa gattataata tgatgatgga aacagcaaag gcagttggta aaatgggtgt
     5641 agacggtata aaaatccatc tattgcatgt tataaaagat actcctatgg aaaagatgtt
     5701 acaaaatggt atgttaactc ttatggaaca agatgaatat atcaatcttg tctgtgacca
     5761 attagaaata cttcctgaaa ctatgataat ccatagactc actggtgatg gtaagaggga
     5821 tgaactagta ggtcctatat ggagcctaaa aaaatgggaa attttaaata aaattgatga
     5881 tactttaaag gctagaaatt cttatcaggg ctgtaagttt gtttaataca aaataataac
     5941 tatagaaatg gttatacaaa tatagtcctt tctatagtta tttagtattt acaaaacaaa
     6001 atattaattt gtacatttat acaatatata ataaaaaata gatagtctaa actgtatcta
     6061 cttatatttt atttgtactg tccactttat tctataaaat ttataaatag ttatttttta
     6121 ataccaaata taatttggta taatttttgt tggaatctac aatgtatacc aataaatcct
     6181 ttttaagtat ataattctaa atactttcag ttttttcaat ctgctttaac ttgttggact
     6241 tataaaatat tcttatttca tcataagaaa gattaagtgc tactactgca gatattaaca
     6301 tcaacatcac tccaaataac ttccctaagg aaaaactttc tcctaatata gtgcaaccaa
     6361 ttattactga accaactaat tctactgatg ccacaacacc tgcaactgac aactctacac
     6421 ctttagatat acctgctgca taaaaaatat atgcaagtgc agctggaaca atgcctaaca
     6481 ttagcataca agataaaaca tctaaatcct tagcataatt taagatttcc caaggtcttg
     6541 aagaaggaat cataaatata gctccaaata agaaactgta tactaatatt gttgaacttg
     6601 aaaattcctt taaagcattt ttactaatag ttggcataag tgcatatgct attgctgata
     6661 atactccaag taaaagccca aaagcgttta aaccttgaaa atccaaacgt ccaccagtca
     6721 ctgccataat tgcaccaata aaacaaagaa taagtgaaaa taatttgctt ctagtaatat
     6781 tttctttata acataatttt gaaaatattg ctaaaaacag tggtgatgta tatagtaaaa
     6841 ctgctgcaat tgatacaccc gcaatgtcaa ttgctttaaa ataacataaa ttaaacattg
     6901 cctgacatat aattcctatt attactgaat atataattcc ttttttgttt atctttaaga
     6961 tttgtggtgt ccttatagat gaatatacgc ctaaaactat aaatccaaaa aacaatcttg
     7021 taaatgctac ttgttctgat gtcagtccat ttcccattaa aaactttcca aataatccaa
     7081 gtgtagccca taataaccct gctattgcta taaatacata ccctttactt ttttctccca
     7141 ttttaaattc ccttctattt ttatttagtc aatttacact cttcttttta agcaaaaact
     7201 atgccatctt aaatcaatat atatcgactc taaaacccta gtctttccaa taatactaat
     7261 aaattttcaa tttttttata tttatttttc gcttacttta agttgattta gacttatttt
     7321 aattgtaaaa tgagttatat ataacttatt taaagttaaa atagactgaa acttatatat
     7381 aaatatcaaa ttttaagtat attaatcaat taaacctatt ttaatatatc attaaaaatt
     7441 taggaggaaa atataaaaat gaatttagat ttggaatttt atcaaaaaat attagaagct
     7501 tcccatgatg aaatatgtgt ttctgatgat aaaggaataa taatatattg taataaagca
     7561 tttgaagaaa attatggtct aaaaaaagaa gatattttgg gaaaaaatgt ttctttttta
     7621 gaagactctg gatattcaac aaaaagcccc ataccaattg tattaaaaac aaagactaaa
     7681 ttttcactgg aacaagatac tcaaacaggg aaaaagctta tcataactgc tacccctata
     7741 tttgatgaaa atggacactt agaatttact gttgaaaatt gtagagatat aactgaactt
     7801 aataatataa aaaataaact tgaagacaca aaaaagcaag taaaaaaata taaatctgaa
     7861 gtagaaacac tatacagaac tgcacttaga attgaagata ctgtaattat ggacggaata
     7921 gttatgagac caatcataaa cacagtaaat catgtttcta aaacggatgt aagtgtactt
     7981 ttattgggtg aatctggaac aggaaaaagc tcacttgcta gatatataca ccacaacagc
     8041 aatagatcta atggcccatt tataacaata aattgtgcaa ctatatctcc acaacttctt
     8101 gaatctgaac tttttggata tacttcaggt gcttttacag gtgcaagtac taaaggtaaa
     8161 gttgggctcg tagaattagc taatggagga actctttttt tagatgaaat aggagatata
     8221 ccacaaaatc tacaggcaaa atttttgcaa ttaatacagg atagaacttt tactccagtt
     8281 gggagcttaa aaaataaaaa ggtcgatata agaattatat ctgctacaaa tgttgattta
     8341 gtttcaaaag taaaagaaaa aaagtttaga gaagatttat actatagatt aaatgttata
     8401 gaaataaaat tgcctcctct tagagaaaga agggataatc tagtggaaat tataaaatat
     8461 tattttaata ggtactcaag tgacttcaac ctaaataaaa ctatttctaa ggaagctatg
     8521 gatgctattg caaattatag attcccaggc aatataagag aattacaaaa tataattcaa
     8581 aaaatcttgc ttacttgtac agataatcat ataacaatag atgacttacc aaacattctt
     8641 acaaaaaata tacatattac caataatgga aataaaacac atatatccca aattaataag
     8701 gttattatat ctgactcaaa atctactaat tataaaaata aaaattttga cactttaatt
     8761 aaagagtatg aaaaaaatat aattttggat gcttatgaaa aatttggtag ttcttataaa
     8821 gtagccaaac accttgaaat ctcacagtct aaagccaata ggttaattag aaagtatact
     8881 aatacttaat tttaaatttg ataaataaaa acttaacact atttacatat tgtaaatttg
     8941 gccatttact gttattatga atatggttga aattatttaa ataaatactg ttgacttagt
     9001 ttcatatatt taccattaaa cttttatcat aaatatcata tcataataat atatttaata
     9061 agtctaataa actatacgag gtgtaaatat gttaatgaat acccatttta ttatggcaaa
     9121 atcaatactt gataatatag atgaaaataa aacattcttt ataagcgaaa aaaattttat
     9181 atatggcaat ataaagcctg atgctttttc taaatataaa ttaaaaaaac attatttaga
     9241 tgagtcattt aatatgattg tttctaaaat aaactatcta tgcagtctta atatagatag
     9301 tctttctaaa tacttttcag taagtagact tagtcaggaa ctaggagtca tatgtcattt
     9361 tttatgtgat tttttctgtg tagctcacag tgaacgttgg gaatttaagc atagcttaaa
     9421 taaacatgtt acttatgaaa gagaacttgg agcatttgca aaagatgttg atttatctaa
     9481 aattaaatgt ggtactataa atagtagttt tgagaagttt tttactaaac tttatagtga
     9541 ttacaaaaag aaaactgatt atatgaatga tttaaaattt tcagcttata cttgtaatag
     9601 tgtcataaat tatatacttg actctatttt atctaataca ataaaatcat atcatatagc
     9661 aaattgcggt taacttaaga atttttaaac ttatataaac ttataattga atataattaa
     9721 aatgactgct ctatagaata taattttata cttctctagg acagtcattt tttatactaa
     9781 ctatttatct ccattataac atctatggca ctttttacac tatctactac ataatttgca
     9841 ctttgcttta catcttccct tgccttagac attgcaaaac tatatttaaa tccttctaac
     9901 atgcaaatat catttggaga atccccaata gtagcaactt catctggact tacatttaac
     9961 gtttttatta catgctctat acttcctctt tttgacacac ttttaggaac tatatttaaa
    10021 gtatatgttc cagaaaaata tatttctaag acttcactaa actcactttt tagataaagt
    10081 tctattctgg ataactcttc caaattttca gaacatacgc ctatatttcc tataagatta
    10141 tcaaaactac ttcttttttc aaaatctggg tcaactataa agtcactaga ataatgtcta
    10201 aaagcagtgg tatcactacc cacaattaca tcacccttat atttaaaata aagttgtgca
    10261 tcacttgact caaatctatc aatgactttt tttactaaat tatcatctat cgttctttta
    10321 aaaattacat tataatcttt atcatatata aatgaaccat tttcacatac atagtatcca
    10381 ttcatatcta aactatcttt gataatatta tgtgcttgtt taaaaattct acctgtagca
    10441 acattaaact gtactccctt tttttctatt tcttcaattg ctactatatc ttcttttgtt
    10501 atggttccat tttcatatag agttccatct aaatcacaaa atatatgttt tatcataaat
    10561 taaaagcctc caaaaacaat tttatatttt actaatactt taatcaaaat aacttaaagc
    10621 ttttctaatt gtattctcaa ttcattaagc aaatctctag tagctcttaa tcttatcttt
    10681 cttctatccc cattaaatat atttttcttt actattgttt ttccatttat atatattgca
    10741 gtataaacca gtcccacagg cttctctttg gttcctccac caggtccagc tactccagtt
    10801 gtagatatac ctatattagc tttaagtcct ttagcaatgc cctcagccat ttctatagct
    10861 gtttgctcac ttactgctcc aaactcttcc aaagtttctc tttttactcc taatcttttc
    10921 attttagaat cattagaata tgttacacaa ccttcaagaa atacagagga tatacctgga
    10981 tagtttataa gagatgaaga aaccaaacct ccagtacaag attcagccac tgctattgtt
    11041 agattttttt ctacaagtag cttagaaaca gcatcttcta aagcagtctc cccttcagat
    11101 atggaaatat ctccttcagt atatacatat ttaccaactc tactttttat tttttcttct
    11161 actggtttta ttaatttaaa agcttctctt tcattttcag cctttgcagt tattcttatt
    11221 gtaacttcta attcttttgc atataaagca actgttggat tagtctgctc attaattata
    11281 tcgagaattt ctaattctag atttgactca cctattccat ataatcttaa agtcttagat
    11341 actagcattt catttgtgaa ttgttgtaag taaggtttga cactctcatt aaacatagct
    11401 ttcatttctc ttggaggtcc aggcaatact attataaatt taccatcttt ttttaaaatt
    11461 gcccctggag ctgtaccatt attatttttt agtactatag catcttttgg aaagtacact
    11521 tgtttcatat tattttcggc catttttttc cctgttttaa caaagaaaga ttccaaaacc
    11581 tctagtgaag gtttatgtag ttctaatttc tgaccaaagt attctgcagc agtttctttt
    11641 gtcatatcat caccagttgg cccaagacca cctgtagtaa ttacaaaatc acttctcttt
    11701 aagctttcat caaaacattc taaaagtctt tgtttgttat ctccaacagt actctgatgg
    11761 tatacttcta ttcccaatga tgcaagttct ttagctaaaa attgagaatt tgtatttact
    11821 atatctccca ataatatttc tgttcctaca cttattattt cagctttcaa aatttatcac
    11881 tccttgattt atagccatta agactagtct taagttcata acaataattt tagcaaaaat
    11941 aataacataa ataaagttaa aaaatcattt aaacatatct ttaaactaga ttattattct
    12001 aaaaccacac ataatataaa cttcgtatat agtggtactt tcatcctcaa ctgttaattc
    12061 atataattaa gtatgtaaat aaaaagttta ctttaaaata ataaaaatta aaataggagt
    12121 gtataatatg aaaatagcag ttataatggg tggaatatca tcagagagag aagtttcttt
    12181 aaattcagga aaagagatat ataataacct tgataaaaat aaatatgaag ttgtaaaggt
    12241 aataatagat gataaaaaag atatatttac aaagatacca gaagatatag attttgcaat
    12301 acttgcttta catggaaaat ttggtgaaga tggatgtata caatcaatac ttgagactat
    12361 ggatatacca tactctggat gtggacctct ttgcagtggg atgtgtatgg ataaaaatat
    12421 aactaaaaaa atgcttagag attcaaacct acctactgct ccatgggttt tagtaaaatc
    12481 agttgatgaa atagactatg atgaaataga taatataggt tatccagtat ttataaaacc
    12541 aaactcagga ggttcaagtg tagccacatt ctttattcat tctaaggatg aagttgaaga
    12601 agcagttaga aaaggtctgg aagttgatga atttgtaatg attgaaaaat atataccagg
    12661 tggagaatat acttcattca tattaaatgg agaagtgttc cctacaatat ctataaaatc
    12721 tgattcagga ttctttgatt atgaagctaa atactcagtt gaaaaaggtg caaaggaaga
    12781 agttgtttac ttagatgaag aacttcaaaa aagagtaaac gaaatttctg agacttgttg
    12841 gaaaattttt aattgcaaag catatgtaag agttgatatg attataagtg aaggtattcc
    12901 atatgttctt gaactaaata ctcttcctgg aatgactcaa actagtttaa ttcctagaag
    12961 tgctgctgct agaggtatta agtacagtga actattagat aaacttatag aatactcttt
    13021 aaattagatg aaataatttg aggtggtaat ttgatatttt caaatctaaa attaaatgat
    13081 aatgaaccaa tttatataca actaaaaaat tatataagtg atatgatatc aaaaggacta
    13141 attccagaca atagtaagct cccttctaca agggagctta gtcagctttt acaagttagc
    13201 cgaaattctg tagttttaac ttatgaagaa ttaaaatcag aaggattaat ctactctatt
    13261 tcaggaaaag gtacatttgt taaatcaaag aataagtctt caaatactac atggtcatta
    13321 aactgggatt gtttagagaa tacatactct aaaaaagcca atgaattgga cattataaaa
    13381 agtgaaattc cttggagctc tgacctgatt tcctttaaaa gtatttctcc agatggagat
    13441 ttattcgaca tggaagaatt aaaaaaatcc tttttaaata gaatttcact agaaggacat
    13501 aaattactca actatggata tgcacaaggt tataagccac ttattgacta tttactagaa
    13561 tatatgacaa acaaaggtgc tgatataagt aataaagata tactaataac aaatggattc
    13621 acagaaggct ttgatattat tatgtcatct tttacccaag aaaaagacta cataatatgt
    13681 gaaaatccta ctcataatac tgctataaaa attatgaaat ctcataacct caatatctta
    13741 ggtgtagata taaatgaaga tggtttggac ttcaatatgc tagaagacaa tttagttaag
    13801 tataaaaata aaataaagtt tgcatacatt acaccctctt atcacaatcc tacaggaatt
    13861 gtaatgactc ctgaaaatag gtacaaattc tataatctta tgaaaaaata caatatagca
    13921 attatagaag atggatttaa tgaagaatta ctctacaata gttctcatat atttcctatc
    13981 tgttccctag ataatatgaa taatggggtc gtatatattg gtagtttttc aaaaatttta
    14041 tttcctggaa tgagaattgg atggatattt gcagataaaa aagtaatcaa taagctagaa
    14101 agtgtaaaaa ggtgcagaaa catacatgta tcctttttag accaaggaat tttatttgat
    14161 tatttaagta atggaggttt tgaaaaatac attaaaaaaa tacgtaaatt ctatggagac
    14221 aaatttaact ttgcatataa atgtataaaa aaatatataa aaacagaata tatcttgggt
    14281 gatggtggtt tgcatatatt tataaaacta aaaaatatag atactagagt tttattagaa
    14341 aaatgttatg aaaaaaatgt tatatttatg cctggagact tattttttac agataactct
    14401 ggttttgata ctttaaggct cggattttct aggttgtctt ttgaagacat tgaaattgga
    14461 ataaaaataa ttggagaaac tataaatgaa atgttctagg ttaactaaat attgttagcc
    14521 tagtttattt ttatgaggta taatatatat agtttatatg aatctaatac tgggggataa
    14581 tatgagtaaa aagtcaaaac gaagaaaaat taataaatta aaattaacga ttgtaataac
    14641 tgtattattt cttgctttat tatctatata tgagatactg ttctctaatc ccaacaaaaa
    14701 aggtaatata aagagtcaag aaactatgca aaataaaaat aatacaacag atgattctaa
    14761 aaataatcaa agctctacca aaaagcagga agataataat atcaaaccta ctttttcata
    14821 ttcttcaata ccagataata taaaaaataa aatgattggt aaatctatgc ctactgatga
    14881 acctataagc tttgatagtc tatcttattt aaaacttaca tattatggat ttgatgaaaa
    14941 aactcatcaa ggagaaatga tagtaaacag tgaactagct ccagaagtag tggatatttt
    15001 taaggaatta tacgaaaaaa aatatccaat tgaaaaaatt aagttaatag atgactatga
    15061 tgctgtagat gaaaaatcta tgtctgataa taatacctca tcattttgtt atagaactat
    15121 agctggtaca aatgtagttt caaatcatgg taaaggacgt gctatagata taaacccatt
    15181 acagaatcct caagtttctg gaaatgatgt tacacctaaa gtaagtacag tttatgctga
    15241 taggtctagc acaaaatttg gaatgataaa aaaaggtgat gattgttata atgcttttgt
    15301 aagcagaggt tggagttggg gtggctattg gaaaaaccca gattatcaac attttgaaaa
    15361 ataatagatt agaaataaag gtgaattata tgaatttaat gacattggaa aatataagta
    15421 aaagctattc tgaaaaaaaa ttactagaaa atatatctct tggaataaat gaaggggaaa
    15481 aaataggatt tattggtgta aatggtactg gtaaatctac cttactcaaa attattgcag
    15541 gagttgaaga aagtgagact ggtaatataa caaaaactaa tggtattagg atagaatatc
    15601 tacctcaaaa tccaacttac aatgaaaatt caactgtact tgaacaagta tttaatggaa
    15661 cttctgaaga attaaagcta cttggtgaat atcaagaaat cctagaaaaa cttaattcaa
    15721 actttacaga ggaattaaat aaaaaattat tatcagtaca cgaaaaaata gatgccttaa
    15781 atctttggga tttagaaagt gaagctaagt cagtacttac aaagcttggt ataaatgact
    15841 ttaatcaaaa aatagcagaa ctttctggtg ggcaaagaaa gagagtctct ctggcatcag
    15901 cccttattac accttgtgag tttttgatac tagatgagcc tacaaaccat ctagacaatg
    15961 atactataga ttggcttgag gaatatctta attccagaaa aggttcattg cttatgataa
    16021 ctcatgatag atacttttta gaccgtgtta caaatagaat tattgaactg gacaaaggta
    16081 gattattcag ttatgatggg aattattcaa tatttttgga aaagaaaatg gaaagacttt
    16141 cgctagaagc aagtattgaa gataaaagac aaaatttaat aagaacagag cttgcgtggg
    16201 taagacgagg agctcaggct cgtagcacta aacaaaaagc tcgtttacaa agatttgatg
    16261 aacttataaa tagagattct tttaaacctg atgaaaatct cgatatatct gttgcatcaa
    16321 gtagacttgg aaataaaata atagaaatac acaatatatc taaatcattt gaagaaaata
    16381 ctgttataga taatttagaa tacactttaa ctcgtacaga tagaattggt ataataggca
    16441 aaaatggtat gggtaaatct acccttataa atatacttaa tggagaaata gagcctgata
    16501 gtggatatat ttcaattgga gaaacagtta aaataggttg tttttctcaa gacgactctc
    16561 atatgaatat tgatatgagg gctatagact atgtaaaaga agctagtgac tatatagaaa
    16621 cttcagatgg tactaggatt acagcttctc aaatgtgtga aagattcctt tttaatggta
    16681 ctatgcaata tactttgata ggtaaattat ctggtggtga aagaagaaga ctacatcttc
    16741 ttaaaatcct tatgacagct cctaatgtgc ttcttttaga tgaacctaca aatgatttag
    16801 atattgaaac gcttaaaata ttagaagaat acctagacga atttaaaggt gtagtagtta
    16861 cagtatcaca tgatagatat ttcttagata gaatttgtaa taaaatattt gcatatgaag
    16921 gtaatggaaa aattcatatc tatacaggta attacagtga ttatcttatt tatagagaga
    16981 ttcaaggaat tgaatttgaa gaatctaaaa gggaatcagt taaaaaagat gactctacta
    17041 ccccaaaaaa agaaaaacct aaaaatgata aaaagcttaa gttctcatat aatgaacaaa
    17101 gggagtttga aaatattgac tctgatatag aaaaactcga atctaaaatt gcaacacttg
    17161 atgaaagtac tgcaaaattt tcaactgatt ttactaaact ccaagaaatt ttagatgaga
    17221 aatctaaact agaaaaagaa cttgaataca aatatgaaag atgggaatat ttaaataatc
    17281 tagctgatga aatagctaat aataagtaat attaaaataa tcttaagttt aataagtttt
    17341 gctttaaatc tgtaatttat aaatatttta aaggaagtgt ctcaaaatga actttttagt
    17401 tttatgagac actctttttt atgagaaatc aaatatattt tcatcatttc aacaatacaa
    17461 aagaggctta tctctatttt gagacagcct ctttcataat taccttctaa tttatatgct
    17521 ctaatatatc tataataatt cttattatat ctatatatcc agtctttcaa tatagtgaca
    17581 attaacttca atatgattta aaaatactaa caacctttca taaagtggat gagattcttc
    17641 tccatattta gcttctaggt tcttgcctat ttctctaaca gtcctttgac catcaatttg
    17701 taaaaaaaca aaactggaat attcatctag ttctattttt ttgtatttag gtattctagc
    17761 ttttaacttt ctaaaaaact tttgaatttt atggtcctgt ttttcaagta tagtaacaac
    17821 acgattttca gctacttcat attcaagtcc atcagtaatt ttaaatacaa tatctaaaac
    17881 atcattactc ttgctcatta ttttttactt tagataaaac aataggtaat gctgtaagca
    17941 caactaaaac tactaataaa gcaattgcca ttgaatttgt tgcagcaaat ccacttggta
    18001 cctttggagt tacaactcca gttacttgta atattatacc tattaaacca atgatagaac
    18061 caccagcaac aagaccagaa gataaactta taccattaga aactttaact tctttttctt
    18121 tttcagtttt agatactaat tcaacaaata aacgaattaa tgctccaact aatattatag
    18181 aagtagttgc aattggtaaa tagaatccta tagctatagt cattattggt aaatttaatg
    18241 catatagaac tattgccata aatactccaa caataatcat aacccaaggt aaactacctg
    18301 acataatacc agaagttaat gttgacatta agtttgcttg tggtaatgca aattgtacat
    18361 tatcaccagt tgctctaagt tggtcagaaa gtaataaaat tactcctaca acaactataa
    18421 caccaactat acttgcaatt gtaaagtaac gttgcatttc gtttttgcta ccaccaataa
    18481 tataagttac tttttgagat tgagtataac ctccagctat agcaatagca acaactataa
    18541 atgaaccaaa taaaagtaat gatttattag cttctaaatc agtccatccc attataacaa
    18601 acactaatgt tacaataact agagaagcta tagtcatacc agaaactgga agatttgatg
    18661 ttccgattgt tcctgttaaa cgaccagcta ctatgacaaa taataaagat aataaaagag
    18721 atatgatagc tccaataatt gccataacaa tgttaccaga aattaagaat gctgctaaaa
    18781 atccaataac tactccacct aataaaagta tcatttgtat agatgaacct tcttctcctt
    18841 ctccagcact tgatttagct ttaagtgttt cttttataga agcgattata gttggtataa
    18901 gttttattgc accaataata cctccacaaa gcatcatacc agcacctata tattttacat
    18961 aactactaga tattgctcca acatccattt ggttaagagg cattgcagga ttattccata
    19021 ccatagctcc atctttagcc atatctgtaa agtatcctat taaaggtgct ataccaaagt
    19081 ttgataaaat acttcctgca aacattgtta aagaaacttc aagccctact ataaatccaa
    19141 ttcctaaaag tagaggattt acttcaatat caaatttcca tttgtagaat ttgcttccta
    19201 caagactcat tacattgttt gctacattta agaatgaacc agttaataca gtaataaatc
    19261 cacttattac aaatccaatt cccatgtact taattgaatc tccaccagcc tctgaagcaa
    19321 caagtgtctc agatatagcc attgattctg ggtacataag tttaccatgt tcttcaacta
    19381 ttagatagtt gtgaactata gcagcaattc ctataccaaa taaaactcca ccaactccaa
    19441 cagctaagcc ttctaagaat gtaatttggc ttccaattaa tataactgct ggtaatacga
    19501 aaataaatcc acttgcaaca gattctccac cacttgacat accttggatt aagtttttac
    19561 caagaatacc ctttgaacga gcaaatgctc caacaaaagc agaacctatt atagctcctg
    19621 gaatacctgc ggcaactgta agaccggctt tcattccaga gtaagttgta gatgcggcaa
    19681 aaatggcagc taaaataata ccgataatca gtacagctac atttccaccg gttctggact
    19741 tatctgtgat atatggaacg taatcttttc cactaacctc accataagca cccttaggta
    19801 attttttgtt cataaaattt tcaccccttt tcaatttgta tatattataa catatataca
    19861 tataaaactt aactttttat tattttacaa atagcgagtc aaaactacta aaatttaacc
    19921 ctatattatt aatttctact tttagatatt tttatgctaa ttttcttttt atttttcaat
    19981 tctactaaaa actattaaga tataaaataa aaaaattttt taatgtaaaa ttaattttgt
    20041 aaaaaaaatg ctttaaaaca cggaaaagta taaaaaatac aataatcatt cttataaata
    20101 aattttcacc atagtaaata tatacagaaa attcttgttt ttatgcaaat tgattatttt
    20161 ataaaaataa gtgtcataaa gaaatgtctg aaatcacttt atgacaccta tcataataaa
    20221 aaaattattc tggtaatgct cttttattta cttttccgat tggtgtaact ggtatcttat
    20281 ctatcctcat tattattgtt ggaatcatat atggaggtag atgctcattt aaatattctc
    20341 taatagttct ttcatttatc ttaccactat cttcctcatc aattacataa tatgcacata
    20401 tataaatatc tccatcatca tttgttctcg atatacaaac aacactttta atttctgtaa
    20461 tattatttat tatattttca atctcatata gctctatcct aaactcatca atttttactt
    20521 gattgtccat ccttccaata taatctaaat ttccatcatc taaccatctt actaaatcac
    20581 cagttctata cattaactta ttatgttcac aagttttgta aggattctct acaaatactt
    20641 gctctgttag ccctttttta tttaaatatc ctcttgatat ttgaatgcct gatagacata
    20701 gctctcctgg tgctccaatt ggacatagtt tgttcttttt atctaataca tatgcataag
    20761 tattaaatat aggttttcct attggtattt ttccatattc tctgtccaca tgaaaagaag
    20821 tcgatacaac agtaaattcg gttggtccat actcattata tagttcataa ttacgctttc
    20881 tatatccttt taatctttct cctccagtct gtacaactct aagtgaatta ttattgcaat
    20941 tttgtataaa taaccttgca aatgctgttg gcaatgctag tatagttatg tcattttcct
    21001 cacagtattc atttactgta tattcatcaa atttagcttc ttcaggcata atatctattg
    21061 atgcacctac aagcaaataa gggaatagtt gtttcattac agcatcaaaa ctgaaactta
    21121 agtatatacc acatatatca ttttctgtag cgcttataga ttttacgcta taataacaca
    21181 tatttactaa actcttatgt tctatagcta tggtctttgg cctaccagtt gaccctgaag
    21241 tagatatcgt atatgcacaa tttgatgatg ttattttttc agttaattca tatccaaact
    21301 taaacatttc ttcatcattt atatcgagta ctatggtatt ctcatttaca accttacttt
    21361 tgagttcatc tgtagttatc actactttcg cattactatc ttcaagaagg taattcaatc
    21421 tttcttctgg attacttgtg tctattggaa aaaatgctcc ccctgatttc ataatcccta
    21481 ttgctgtaat aattatgtta atatctcttg gtaacattac agctactatg tcttcacttt
    21541 ccactcctat atgatttaaa taacctgcaa gtttatcagt tacttcatcc aattctttat
    21601 atgttaactt tctattttca tccctagcag ctatattact aggtgttacc ttaacttgct
    21661 ccctaaataa atcaacataa cttttatcat agggtacttc atattgatta ttattaaagt
    21721 cttccaataa tactttttct tcttccttac atacaaattc taaatcttct attaaaatat
    21781 cattatcttc tattatttgc tctattatat aatcaaattg atttaaaatt cttctaatag
    21841 tttctctttt atatatagat ggtttatact ttatttttat tttaagtgcc ctcttagtat
    21901 atactattac agataaatca tatccttttt tttctatgtc ataatcatat gataaatcaa
    21961 aacttttagc tataaatatt gtgtttataa gcttagtatt tagatgattt ttattctcta
    22021 tatctgataa caaatagtat ccatactcta aagacctgct ccactgcctt tttagcttcc
    22081 ttacaacatc tataaatttt tcactttgtc taactcttac tcttattgga attatattca
    22141 ttgttttacc aaaaactaca tcatcttcat atatatactt ttgaagtata aggccatata
    22201 tagtttctat gatagagtct atgctaatat tgttcacttt agaatattga attaaccttt
    22261 catgtttctc aatattcatc ttaaaaacct catctactac ttcatcagaa caatctttat
    22321 aaaaaaaatc atttggaatt tttgctatat tcgtataatc atctaacaaa tccatccaat
    22381 aattcatagc tcgttctaaa ttaacttcat acatatcaaa attccccctt actactaagt
    22441 ctatagaaaa aattcttttg gaattttatt ttcacaatat ataaatatat taataataca
    22501 tatgcaagct ctaaaaacat gagcttgcat aaaattacac ttattatgac tactaaattc
    22561 gtaatattta caatgtttaa aatatattat aa
//
LOCUS       DAEHWM010000068        22293 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.069, whole genome shotgun sequence.
ACCESSION   DAEHWM010000068 DAEHWM010000000
VERSION     DAEHWM010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22293)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22293)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22293
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.069"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            145..480
                     /locus_tag="KNP36_002564"
     CDS             145..480
                     /locus_tag="KNP36_002564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874425.1"
                     /translation="MYNIDDMIYNCPVEALSNILGKKWVAIIIWKIQEDKKRFGELQR
                     AIPDCSKKMLVQQLDFLIEQGIIVNQKKLVNNVVESTYFLSESGLRLLPVMEKMIMWS
                     NKNLNCDKY"
     gene            617..1894
                     /locus_tag="KNP36_002565"
     CDS             617..1894
                     /locus_tag="KNP36_002565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HBF0874426.1"
                     /translation="MQNVNLFLVFIEGIVSFFSPCILPILPIYLSILSNSSVENLKEG
                     KTSFIGSSLFKNTIFFALGISTTFFILGSSVKVLSMFFNENKDLIMFIGGIIIIIMGL
                     FYMGIIKSSILNREKRFNVKFKEMKAITAFILGFTFSFGWTPCIGPILASVLVMVSSS
                     SNHLSANLLIAVYTIGFILPFIITAMFYSKLFKTIDKIKSNMEIIKKIGGIILIVSGI
                     LMMVNGFGSISKHFNTSQNSKIESKQEENKRENSTDKEENSDGNDSQKDSNNDNNDKG
                     SNDEDRIKSIDFTLTDQYGKTHKLSDYEGKVVFLNFWATWCPPCKEEMPYIEQLYKDY
                     NKNNDDVVILGVASPNLGREGSREHVVNFLKDQGYTFPVVLDEDGALAYQYGINAFPT
                     TFIIDKEGYVTQYIPGAMDKATMASFIENQRNK"
     gene            2015..3403
                     /locus_tag="KNP36_002566"
     CDS             2015..3403
                     /locus_tag="KNP36_002566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBF0874427.1"
                     /translation="MKKTFDAIIIGFGKGGKTLAGDLANRGLKVALIEKSNKMYGGTC
                     VNVACIPTKSLENSANSVKTKNINSWDEVQAEYEKAIDKKETLITKLREANYNKLNSN
                     ENVTIFTGMGTFIDEKTVQVKTENEIYELVADNIFINTGSRPFIPNIKGIENKNIVYD
                     SESLMNLRTLPKKMTIIGAGFIGLEFAGIYSSFGAEVTILNSNNGILPNEDVEDSEEI
                     IKLLAKRNVKIVNNANIKEIKEVSELAIVEYEVDGKSKELTSNMILVATGRKANTEEL
                     GLENAGIELNERGFIKVSETLKTNKEHIWAIGDINGGPQFTYISLDDYRIVINQLFGD
                     KTRTTNDRKNIPNSIFISPAFSRVGLNVKQAKEKGYEVLVAKMPVEAIPRAKQIGKAD
                     GFIKIVIDKKSNKILGASMICENSSEIIHLIQLAVDLEVEYTYLRDRVYAHPTMTEAL
                     NDILSPNMIKEV"
     gene            3774..4487
                     /locus_tag="KNP36_002567"
     CDS             3774..4487
                     /locus_tag="KNP36_002567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017208807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF434 domain-containing protein"
                     /protein_id="HBF0874428.1"
                     /translation="MNKISKRGFDDSDKRWFSSKELTRLIKSKEEIEWLLNRDYKIDP
                     VVTFVGDRYQFSIRQRDALKRAVCTDEKNIIRQSKRLSLDKIKEDTVNIDGFNLIISI
                     EVALSGGTLVIGSDGNIRDLAGLRGTYKIIDKTEEALNLIGKFFNKYNAQNLKFYLDA
                     PVSNSGNLKYRILEHAKTWGIETEVELVKNADVVLEKLDRVVSSDAVIVDKCISYFNV
                     ARGIIEEYIKECNIINLNK"
     gene            4605..5474
                     /locus_tag="KNP36_002568"
     CDS             4605..5474
                     /locus_tag="KNP36_002568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SH3 domain-containing protein"
                     /protein_id="HBF0874429.1"
                     /translation="MRGWICVKLTKLNIKKYRAPIYKYALANVNLRSAKSTNSSIITV
                     IPQGAKMEVLDEEDDWIKVMYNSQEGYVYKDLVSVSEYAWSNLNLREDKSTTSNIITV
                     IPEKSRVEVLQVDGDWSKVVYDDKIGYVFNYFLSIDGNKPNELDYKYFYTDMIKFVNE
                     NNIKSTSDYLIVTDLRNKYTYIFKKDNGGWGQLYKWQCTIGKPETPTITGIFYISGRK
                     PSFGTDEYSVKYATRIKGGYYYHSVLYDSTGSYIIDGRLGEALSHGCIRLSTENAKWI
                     YDNIPDTTTVIIH"
     gene            complement(5629..6774)
                     /locus_tag="KNP36_002569"
     CDS             complement(5629..6774)
                     /locus_tag="KNP36_002569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HBF0874430.1"
                     /translation="MSIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNG
                     TVKKVTDILSQIDVDFVVYDEVKQNPTVTNVNKGLKILKSENCDFVITIGGGSPQDCG
                     KAISILATNGGDIRDYEGINKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMI
                     MVDTNSLATMTVNDPELMISKPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAI
                     KQIFKYLPRAVKNGNDIEAREQMCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHG
                     VCNAMLLPIVEEENAKSAPAKFRPIAEVIGMDVNNKSDKECVDFVIDKIKALSEEVGI
                     PKSLKDVGVDNPNFELLAENSMKDACAGANPVFFDKDKIIELFMKIS"
     gene            complement(7107..7883)
                     /locus_tag="KNP36_002570"
     CDS             complement(7107..7883)
                     /locus_tag="KNP36_002570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IclR family transcriptional regulator"
                     /protein_id="HBF0874431.1"
                     /translation="MTSDNHRPTARILDILEALAESENGYTLTEIADVINAPKSSIFP
                     IVHTLNARKYITIDKNTSKYSIGIRSYTLGSSFFEKRTIFNYIIDEMTNIVNSCSETC
                     QLGILDNNEVLYIGKVDSPEPIRLISYVGKKIPANCTGLGKALLCDFDKEKLISLYPD
                     GLKGFTEKSITDFDVLYDQLLEVQRTQIASECEESMEHLKCLAVPIRKNGCIRAAVSV
                     TLPLFRANDEKIELIKKLLLNAQKNIQSMMEERNEDIVIN"
     gene            8465..9439
                     /locus_tag="KNP36_002571"
     CDS             8465..9439
                     /locus_tag="KNP36_002571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-keto-3-deoxygluconate permease"
                     /protein_id="HBF0874432.1"
                     /translation="MIMDFIKKIPAGMMIVPMFIAAFINTFCPDIVQIGSFTTAVFSS
                     VGSATIIGVQLVCLGTQLQFREMPKVLKRGGILLGSKFAIGALIGILIGKLFGMDGVL
                     GLTTLAVISAVTNSNGSIYLSLMTSYGDETDCATMSLLTLNDGPFFTLIALGTSGLAN
                     VPLLSLLAAIVPILVGMIIGNFDKKMKEFLEPGCNLLVPFVGFALGSSINLASILKGG
                     LSGVLLGLISVFVGGIFIVFCDKFIGKRPGYAGWAVATTAGNAIAVPAAVALVDPSWQ
                     PYVATATTQVAAAVVVTAILVPLITSWWAKKYGCPKFPKQNEDGTITA"
     gene            9537..9842
                     /locus_tag="KNP36_002572"
     CDS             9537..9842
                     /locus_tag="KNP36_002572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422587.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBF0874433.1"
                     /translation="MINAVIIDEKDNVAVAIEAIAKGSEISFKLKDKTVKTITALDDI
                     TIYHKLAIKDMAQGDKVTKYGEHIGEANQEIKSGQHVHIHNVRSVREDLDKQVMTNI"
     gene            9998..11158
                     /locus_tag="KNP36_002573"
     CDS             9998..11158
                     /locus_tag="KNP36_002573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UxaA family hydrolase"
                     /protein_id="HBF0874434.1"
                     /translation="MKFYGYKRPDGRVGIRNHILILPTSVCASDTTRIIASQVQGAVT
                     FNNQNGCSQVHSDQQLTMDVMAGYAANPNVYGVIVVSLGCENCQNDLVVDAIKERTNK
                     PIKTLVIQEEHGTLKTIEKAVRYAREMAQEASLLRKEEFPISELILGTECGGSDPTSG
                     LAANPLIGELSDKLVDLGATSILSETTEFIGAEHILARRAVNEEVKEKILHIVHRYEN
                     SLKLVGEEVREGNPSPGNIAGGLTSLEEKSLGCIHKGGHRQISEVYDYAKQIDKKGLV
                     IMDTPGNDASSVAGMVAGGAQIVVFSTGRGTPSGNPIAPVIKITGNKITFANMEDNLD
                     FDASPVIYGPQTMEELTDDLLNMVVDVANGKQSKAESLGYTEMAIARVCNYV"
     gene            11208..12110
                     /locus_tag="KNP36_002574"
     CDS             11208..12110
                     /locus_tag="KNP36_002574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="HBF0874435.1"
                     /translation="MKFVSFTEGENECKRTGVFSKDELFIIDVNSLNLSRNFKDLNEL
                     IQNVSSEDIIKLKTIINESTFYNYDVFKRERCTVHVPIEKPIHDILCVGVNYKDHLEE
                     TQTHFDDSFEEPQKTVYFTKRVTKAIGPEDEIDGHFEINNQLDYEVELGVVIGKTGVN
                     IRKEEVEDYIFGYTVINDISARKLQKEHVQWFRGKGLDTFTSLGPCILHKSAVPFPIK
                     LKVCSRVNGEERQSSNTGLFISDVSDIVSELSKGMTLEAGDIIATGTPSGVGMGFSPP
                     RYMSSGDVVECEIESIGILKNYIK"
     gene            12190..13083
                     /locus_tag="KNP36_002575"
     CDS             12190..13083
                     /locus_tag="KNP36_002575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HBF0874436.1"
                     /translation="MKAEFLTPVVTIFDEEGNLDKEGNKKVYDHLIDGGVDGLVIMGS
                     TGEFFNMSMDMQKELIDLVTSHVNKRVKVFIGTSRMCINESIELSNYAHNSGADGVMI
                     ISPYYFSLDDDSIELFYSEIAKNTEAEIYLYNYPDRTGYDLSPELTLRLARKHKNIVG
                     YKDTVTLMGHTRDLINTMKIEFPEFKVYSGYDENFIHNLMSGGAGCIGGLSNLIPEVC
                     SKWAEAYNNRDMEKVIEIQKYINKAMDFYLITNPFIPAMKKAMNIRGLQISDYMTAPF
                     VKPNEKQVCEIKKLMNELNIC"
     regulatory      13136..13317
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            13545..14675
                     /locus_tag="KNP36_002576"
     CDS             13545..14675
                     /locus_tag="KNP36_002576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0874437.1"
                     /translation="MKFKSNVLKQFFLIAMVIFMVGGLIGCSKSDKENKQASTGKKLE
                     LKYASGFSVEDLEDGIKKVTDGDNRELILIPKKIKIPEKYKNANIVRTPVDNVLIAST
                     TQACSLRTIDELDSIKAVTTQEQYWTIKEIKDLMKDGKIHYVGSNLAPDYEKIVDLNP
                     DLTIVSSGLSEADTKFIDKLKELGLNYVVDNEYKEQNPFGRMEWTSLIAAFYDKEDMA
                     TSELNKTVQKVEEVSKKIKNKAKPKVVWASVYEGSAYIAPKDSYVDNMIKMAGGINAC
                     ASIDSNEGRVSIEQLHEVAKDADIFVYSSSSDYAPNLDSIKSSAPVLADLDVVKNGNL
                     WVFAPDYYQSVDKTDELIVDLVEMFHPGTTGEKIKHYINYDK"
     gene            14747..15772
                     /locus_tag="KNP36_002577"
     CDS             14747..15772
                     /locus_tag="KNP36_002577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HBF0874438.1"
                     /translation="MDFINKMRIRNTTIFIVLIISMILTFLVCVAFGSVKIEFKEVID
                     VVLRGMDNTEHYKIIYNIRIPRVLATMVGGACLAVSGILLQIFFKNPIVEPYILGVSS
                     GSTLSVALMILGGYTLGFESVNSMSIFVAAFIGALIVMSIVILFANKVKNITTLLIIG
                     IMTGYVCSGITNVLQSFANSDKLKEFTMWSMGSFSGFTWEKVEILIIVGILGLLMTVF
                     IIKPLNAFLLGEEYAKSIGINIRFFRVLIVFISSILAAIVSAFAGPIGFIGLAVPQIS
                     KMIFKTSDNRVLIPVVIFLGSIVTALCDLISRVILSPVELPISTITSLLGAPIVVMLL
                     VKRKDRA"
     gene            15775..16971
                     /locus_tag="KNP36_002578"
     CDS             15775..16971
                     /locus_tag="KNP36_002578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874439.1"
                     /translation="MLKTNNLSVGYNNKVVISNINVEVKNGEILCLLGSNGAGKTTLL
                     RSLSKLISPIKGEIYLNGVNINCISRKALSKKMALVLTNRLLGDLMTVQDIVNIGRYP
                     YTGFFGSLSKKDLIMVDEALESVDALHLKKRYFDELSDGEKQKVLVARALVQEPEIII
                     LDEPTTHLDIKHRLELINILKKLSKEKSISVILSLHEIDIALKSCDKVALIKNNKVIA
                     YGQPEDVVDEDIINSLYELDDKNFNSLLGSVEISNKSKNEVFIIGGGGKATPIYRAFT
                     KKGIGLYSGIIHENDIDYEIGRTMGIKMFTENPFEPISDESFDLAIRNLNDSKIIIDT
                     GFSVGETNKRNIDIIKEALKLDKKVYSFRNRDESKKYYDSLDSKIEHIDKVSQIINSA
                     DINNLL"
     gene            complement(17099..17824)
                     /locus_tag="KNP36_002579"
     CDS             complement(17099..17824)
                     /locus_tag="KNP36_002579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBF0874440.1"
                     /translation="MKTISKQELEKTLEKHYLWLKNNNAGEKADLKELRLENMDLRGY
                     CLSNIDFSWSDLINLNLEKADLENSIFNNSYLSDCSLKNSILKNADLSGASFRFCDLS
                     NSDIRGANLENSNLEYATLNGVISDESTRFFKLYCPETGAFIGYKKCFNFRMVQLLIP
                     SDAKRVSATSNACRCDKAKVLSITSVDGKESFKSARAYADENFIYRVGETIVAEDFNE
                     NRWKESTTGIHFFLTREEAIGYL"
     gene            18302..20401
                     /gene="nrdE"
                     /locus_tag="KNP36_002580"
     CDS             18302..20401
                     /gene="nrdE"
                     /locus_tag="KNP36_002580"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HBF0874441.1"
                     /translation="MNWIELNNQVIIKNEQGKYQLEKDKEALSSYIEEFIQPKLRKFN
                     NLEERLKYLIDEGYYSKEVINQYSIDVIKNIYDMIDKHKFEFQSYMSANKFYQNYALK
                     SNDGKEILETYNDKVLIVALTLGNGDKDLALNLADKIVKQEFQPATPTFLNAGRKRAG
                     EMVSCFLLSVEDSTEGISYAISSSNHLSKIGGGVALNLSKLRASGESIKDIEGAAGGV
                     VGVAKMLEQSFSYFNQMGARQGSGAVYLTVFHPDFELLMDTKKINADEKIRLATLSLG
                     AIIPDKFMELAEKNEVAYAFYPHTVYKKYGVSLDEIEMDKWYDKLVNDSDIRKKEINP
                     RQMLTKIAQMQQESGYPYVVYIDTANREHTLKDVGIIKMSNLCCEIFQYQTPSEIEGY
                     GGKNEWGQDISCNLGSLNIANVMDNKTIESTVETAIRALSFVADSTDIKPVPTVSNSN
                     SKSHSIGLGAMNLHGYLVRENILYTSDDAIDFSNVFFAMVRYYSIKASMKIAIERNQT
                     FEGFDKSEYVKGRNSKVLSKYYEQSYLPKSEKVRALFEGIYIPTKEDWTKLLDEVKEK
                     GIYNAYLMAVAPTQSISYVQNATSSIMPITEPVEVRTYGDSTTIYPMPFLTNDNMLYY
                     QSAYRMDMRKVIDLVATVQNHVDQGISTTLFVTDEKTTRDIARHYIYAYKKGLKSLYY
                     TRTKMTRDTHECLVCSV"
     gene            20414..21385
                     /gene="nrdF"
                     /locus_tag="KNP36_002581"
     CDS             20414..21385
                     /gene="nrdF"
                     /locus_tag="KNP36_002581"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HBF0874442.1"
                     /translation="MTFNLHKIHNAVNWNREEDGFTQAFWEQNVKQFWLPEEISVSKD
                     IKVWNELSNKEKELYKKVLGGLTLLDTKQGNNGIPSMMSLTENLQRKAVLSFMGTMEE
                     IHAKSYSSIFMTLLSNLEIDELFEWIETEPTLQRKADLVLAQYENTTNQEGLYLSMVT
                     SVFLESFLFYSGFFYPLYLSGQGKMVASGEIISLILRDESLHGKYIGLLAQEIYDSFD
                     KMDKEMLEEKMYSILYSLMENEIEYTNVIYRESGLEKEVVNFLKYNANRALENLGFEK
                     LYTVDAINPIVLNGLSTETKTHDFFSTKGNGYQKGVYEELEDEDFII"
     gene            21461..22087
                     /locus_tag="KNP36_002582"
     CDS             21461..22087
                     /locus_tag="KNP36_002582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBF0874443.1"
                     /translation="MKYEWRKRDKELYLPKKNPVIVEIPEQKFIMLKGSGDPNSKEFT
                     EAIGVLYSLAYAIKTMPKKGIVPEGYFDYTVFPLEGIWDKGEKSKGLDVLIKEDLIYT
                     IMIRQPDFVTQDLLDKATDIVKKKKPHNLLEKVRFGSINEGLCVQMLHIGSYDNEPES
                     FDIMNEFCKKNKLIRKSYTHREIYISDARKVSPESLKTVLRFEVEREV"
BASE COUNT         8652 a         2453 c         3893 g         7295 t
ORIGIN      
        1 tacataaaat ctaaaatagt ttgtaatagg agtatatata ataaaaattt taattaaata
       61 aagctaggta tatttataat attaataaat atattgctat aaaagtttgt ttaataaatt
      121 aaataaagaa aagaggagaa taaaatgtac aacatagatg atatgatata taattgtcca
      181 gtagaagctt tatcaaatat tttaggtaaa aaatgggtgg ctataattat atggaaaata
      241 caagaagata aaaaacgatt tggagagcta caaagagcta taccagactg tagtaagaaa
      301 atgttagttc aacaactaga ttttttaatt gaacagggga ttatagtcaa ccaaaaaaag
      361 ttggttaata atgttgtaga gtcaacatat tttttaagtg aatcaggatt acgattgctt
      421 cctgtcatgg aaaaaatgat tatgtggagc aataaaaatt taaattgtga taaatactaa
      481 aatttactct gtaagtaatg aaaatttaat taagctatga gtagaaaaat gtattaaaat
      541 tacataattt tttagttaga ttttaattta gaaatgggat tgtaatattg gaaataaaat
      601 aaggaggaat tttaatttgc aaaatgtaaa tttattttta gtatttatag aaggtatagt
      661 atcattcttt tcaccatgta tactgccaat tttgcctatt tatttgagta tattgtcaaa
      721 tagtagtgta gaaaatttaa aagaaggaaa gacgagtttt ataggaagtt ctttatttaa
      781 aaatactata ttttttgctc ttggaatctc aacaacattc tttatattgg gttcatcagt
      841 aaaagtattg agtatgtttt ttaatgaaaa taaagattta ataatgttta ttggtgggat
      901 tataattatt atcatgggat tattttacat gggaataatt aaatcttcaa tattgaatag
      961 agaaaaaaga tttaatgtta agtttaaaga aatgaaagca ataacagctt ttatattagg
     1021 ttttacattt agttttggat ggacaccttg tattggtcca atattggcat ctgtattagt
     1081 catggtttca agttcaagta atcatcttag tgcgaatctt ttaatagcag tatatactat
     1141 tggttttatt ttgccattca taattacagc tatgttttac agtaaactat ttaaaactat
     1201 agataagata aaatctaaca tggaaattat taaaaaaata ggtgggatta tacttatagt
     1261 atcaggaata ttaatgatgg taaatggatt tggaagtata agcaaacact ttaatacgtc
     1321 acaaaatagt aaaattgaaa gcaagcaaga agaaaataag cgagaaaatt ctactgataa
     1381 agaagaaaat tctgatggta atgatagtca aaaagactct aataatgaca ataatgataa
     1441 agggtctaat gatgaagata gaataaagtc tattgatttt actttaacag accagtatgg
     1501 taaaacacat aaattaagtg attatgaagg caaagttgta ttcttaaatt tttgggctac
     1561 atggtgtcct ccatgtaaag aagaaatgcc ttatatagaa caactgtata aagactataa
     1621 taaaaataat gatgatgtag taattttagg agtagcttca cctaatttag gtagagaagg
     1681 ttcaagggaa catgtagtta acttcttaaa agaccaaggt tatacattcc ctgttgtact
     1741 tgatgaagat ggagcattag catatcaata tggaattaat gcttttccaa ctacatttat
     1801 aattgacaag gaaggatatg taactcagta tattccagga gctatggata aggcaactat
     1861 ggcatcattt attgaaaatc agagaaataa ataaaagtat ttaagtataa gtttataaat
     1921 caatttaagg ttacaaaaaa gtgcctaatt gtaccaccta aataatcttg ttatagtaaa
     1981 agtataaaca atacaagaaa gggttgaatt ttatatgaaa aaaacatttg atgctataat
     2041 aataggattt ggaaaaggtg gaaaaacatt agcaggggat ttggcaaaca ggggattaaa
     2101 agtagcttta atagaaaagt caaacaagat gtatggtgga acatgtgtaa atgtggcatg
     2161 tataccaaca aaaagcttag aaaattcagc aaacagcgta aaaacaaaga atataaattc
     2221 ttgggatgaa gtacaagctg aatatgagaa agctatagat aaaaaagaaa ctttaattac
     2281 aaaactcaga gaagctaact ataataaatt aaattcaaat gagaatgtaa ctatattcac
     2341 aggaatggga actttcattg atgaaaaaac agttcaagtc aaaactgaaa atgaaattta
     2401 tgagttagta gcagataata tatttattaa tactggttca agaccattta tacctaatat
     2461 taagggaatt gaaaataaga atatagtata tgatagtgag tctcttatga atctaagaac
     2521 tttacctaaa aaaatgacaa ttataggagc tggatttata ggtttagaat ttgctggtat
     2581 ttatagttca tttggagcag aagttacaat attaaactct aataatggca ttttaccaaa
     2641 tgaagatgtt gaggattcag aagaaataat aaaattactt gcaaagagaa atgtaaaaat
     2701 tgttaataat gcaaatataa aagagattaa agaagtttct gaattagcaa tagtagaata
     2761 tgaagtagat ggtaaatcta aagaattaac aagtaatatg atacttgtag ctacaggaag
     2821 aaaagcaaat actgaggagc tagggctaga aaatgcaggt atagaattaa atgaaagagg
     2881 atttattaaa gtctcagaaa ctcttaagac taataaagag catatatggg ctataggaga
     2941 tataaatgga ggtccacaat ttacttatat ctcattggat gattatcgca tagttattaa
     3001 tcagttgttt ggagataaga ctagaacaac taatgataga aagaatatcc caaattctat
     3061 atttataagt ccagcatttt caagagttgg tcttaatgtt aaacaagcta aagaaaaggg
     3121 atatgaagta ttagtggcaa agatgccagt agaagcaatt ccaagagcta aacagattgg
     3181 caaggcagat gggtttataa aaatagtgat agataaaaaa tccaataaga tacttggagc
     3241 tagtatgata tgtgaaaatt caagtgagat tatccatctt attcaattag ctgtagattt
     3301 agaagtagag tatacatatt taagagaccg tgtttatgca catccaacta tgacagaagc
     3361 tcttaatgat attctatctc ctaatatgat aaaagaagta taacataagt ttaatatata
     3421 aacctaaaat tatcattata agtagatttt agaaagaggc tatctcaaaa aatagagata
     3481 agtctctttt ttactgttta aatgataaaa atatatttga ttttataaaa gaagattatc
     3541 ttatgaacta aaaagtttat tttaaaacac tacctattta tgttataaac ttataaatat
     3601 aatatagaat ctattattct gtattattaa gtggggttaa gcgttataat taattataaa
     3661 tattgaataa tctaaatgga taagataatg gtattaaaaa ttatcttaaa aggtgaaata
     3721 atctgtattt aatgtagtac agttatatct ttaaagcaag gtggtgaaat gatataaata
     3781 agatatctaa aagagggttt gatgatagtg ataaaagatg gttttcaagt aaagaattaa
     3841 caagacttat aaagtctaaa gaagaaatag aatggttatt aaatagggat tacaaaatag
     3901 acccagtcgt tacttttgtt ggtgatagat atcagttttc tataagacaa agagatgcat
     3961 taaaaagggc agtctgtact gatgaaaaaa atattataag acaatcaaaa aggctttctc
     4021 tagataaaat caaagaagat accgtaaata tagatggctt taatttgata atatccatag
     4081 aggtagcatt atctggtggt actctagtaa taggaagtga tggcaatata agagatttag
     4141 caggtcttag gggaacctat aagattatag ataaaacaga agaagctttg aatctgatag
     4201 gtaaattttt taataaatac aatgcacaga atcttaaatt ttatttagat gctccagttt
     4261 ctaattcagg aaatttaaag tataggatat tagagcatgc caaaacttgg ggaattgaaa
     4321 ctgaagtaga attagtaaaa aatgcagatg ttgtattgga aaaattagat agagtagtta
     4381 gtagtgatgc agtcatagtt gacaagtgta taagttattt taatgtggct agaggtataa
     4441 ttgaagagta tattaaagaa tgtaatatca taaatttaaa taaatagata aatataggtg
     4501 agaatatata agtatatgta gcaatattct tagtaataca agtaaagttt gaaaatagga
     4561 gaacgaatac atatcgaatt tcataaaatg ttgtaaaaag acatatgaga ggatggatat
     4621 gtgtgaaatt aactaaacta aatattaaaa aatatagagc acctatatat aaatatgctt
     4681 tagcaaatgt aaatttgagg tctgctaaat ctactaattc aagtatcata acagtaatac
     4741 ctcagggagc caaaatggaa gtattggatg aagaagatga ctggattaag gtgatgtaca
     4801 attctcaaga aggatatgtg tataaggatt tggtatcagt aagcgaatat gcttggagta
     4861 acttaaactt aagagaagat aaatctacaa cttccaatat aattacagta attcctgaaa
     4921 aatctagggt tgaagtcctt caagtagatg gagattggag taaggttgta tatgatgata
     4981 aaataggata tgtttttaat tattttttat caattgatgg gaataaacca aatgaattag
     5041 attataagta tttttatact gacatgatta aatttgttaa cgaaaataac attaaaagta
     5101 ctagcgatta tctaattgta acagacctta gaaataaata tacttatatt tttaagaaag
     5161 ataatggagg atggggacaa ctttacaagt ggcaatgtac tataggcaag cctgagactc
     5221 caactataac aggtatattt tatataagtg gaagaaaacc ttcttttgga acggatgagt
     5281 attcagttaa gtatgctact agaattaaag gtggatatta ctatcattct gtactatatg
     5341 attcaacagg aagttatata atagatggca gacttggtga agctcttagt catggatgta
     5401 taagattaag tacggaaaat gcaaagtgga tatatgataa tataccagat acaacaacag
     5461 ttataattca ttaagaaaaa ttttgagttt tttattggga taataattct taaattaata
     5521 gaattatata ttaacttctc ataaagagta ctatttaaaa agtgtaataa gagagtgcta
     5581 ttaacaaaac aaagatattt tgaggcactc tcttataaat atacataatt aagatatttt
     5641 cataaacaat tctataatct tatctttatc aaagaaaaca ggattagcac cagcacaagc
     5701 atctttcata gagttttctg caagcaattc aaaattagga ttatcaacac ctacatcttt
     5761 taaagatttt gggattccaa cctcttcaga aagagctttt atcttatcta ttacaaagtc
     5821 aacacactct ttatctgatt tattatttac atccattcca ataacttcag ctattggtcg
     5881 gaatttggca ggggctgatt tagcattttc ctcctcaact attggaagta gcatggcatt
     5941 acatactcca tgaggtaaat catataaacc tcctaattga tgagccatag catgtacatt
     6001 tccaagacct gcattactaa aggcaattcc atttaaaaaa caagcataac acatttgttc
     6061 tctagcttct atgtcattac catttttaac agctcttgga aggtatttaa atatctgctt
     6121 tatagcatat aaggcagttg aatctgtaac atcataagca ccattagcta ctacagcttc
     6181 tatagcatga gttagtgcat ccataccagt tgctgctgtt aaattagatg gtttgctaat
     6241 cattaattct gggtcattta ctgtcattgt ggctagtgaa ttggtatcaa ccattatcat
     6301 ctttacatgt ctgtcttcat cagttataac atagtttatt gtaacttcag cagatgtacc
     6361 agcagtagta gttatagcta tgataggaag acatttttta gaagttttgt tgataccttc
     6421 atagtctcta atatctcctc cattagtggc taatatagag atagctttac cacagtcttg
     6481 tggagaacca cctcctatag ttataacgaa gtcgcaattt tctgatttta atattttaag
     6541 tcctttattc acattagtta cagttggatt ttgtttaact tcatcataaa caacaaagtc
     6601 tacatctatc tgagataaaa tatctgttac tttttttaca gtaccatttg aaactagaaa
     6661 tttatcacta acaataaatg cttttttagt tcctaatgat ttaattgaat ctttagcttc
     6721 attaagacat cctttcccaa gtaaatttat tggtggtaca taataaatgc tcataactaa
     6781 aatctccttt tattttcatt gatttttatg taaaaatata tatctaacaa ttttcactaa
     6841 cttactcata atatatcgta tcttagattg agataggatt gttggttctt atataagaac
     6901 ttaattcgta attacgatta tgattagaat ttaacatagt atttttatca tgtcaataaa
     6961 aatataaaaa atattataaa aaaaacaaag ttactgtagt taaatcagca actttgtttt
     7021 tatagtataa atcaaataaa tacattagtt taaaacaaaa tttttaatta ttatgttttg
     7081 atatcttcca tatacagaat attaatctaa tttattacaa tgtcttcatt acgttcttcc
     7141 atcattgatt gaatattttt ctgagcattt aagagtaatt tttttatcag ttctattttt
     7201 tcgtcattag ctctaaataa aggcagtgtt acactaacag cagctcttat acatccattt
     7261 tttcttattg gtacggcaag acattttagg tgttccattg attcctcaca ctctgaagct
     7321 atttgtgttc tttgaacttc aagaagctgg tcgtataaaa catcaaaatc tgtaattgat
     7381 ttttctgtaa aaccttttag accatctgga tataagctta ttagtttttc cttgtcaaaa
     7441 tcacataaaa gagcttttcc aagacctgta caattagcag gtattttttt tccaacataa
     7501 gaaataagtc taattggttc tggagaatct acttttccaa tataaagaac ttcattattg
     7561 tcaagtatac caagctgaca agtttcagaa caggaattaa ctatattagt catttcgtca
     7621 attatatagt taaaaatagt tcttttttca aaaaatgaag accctaatgt gtaagaacgt
     7681 atccctatag aatatttgga tgtgttttta tcaatagtaa tgtattttct agcattaagt
     7741 gtatgaacta taggaaagat gctacttttt ggagcattga taacatctgc tatttctgta
     7801 agagtatatc cattttcgga ttctgctaat gcttctaaaa tatctaatat cctagctgtt
     7861 gggcgatgat tatctgaagt cataaatttc cccctctttt tattaattta aagtattaga
     7921 atatgttgat tttagcacac tatacgatat tttacaatgt agaaaataaa tatgtaaatt
     7981 tatatataaa taagctcttg atttagatac agatagatat ttttttagac tgtacattaa
     8041 ggaataacta atttccaaaa tgtacctaaa gaaagtaagt gatatttagt tatataattt
     8101 aagtaaatat atgcaatagt tatttttata tgtaaatatc aaaatattat gaacttatat
     8161 tttatctatt ttttacactg tataaaaact ttatagtttt gaatactata taattttaaa
     8221 tacgctgtat ttttgcatat aaggaagtca tttgataata tacaaggtat tatcagaaag
     8281 tttgaaaaaa ttttgacaaa aatttatttt ttttattgac tcataaatag gaaaatgcta
     8341 tcattaattc aaagattcgt aattaaaaac ttagttctta aatacgaacc gaaacggccg
     8401 ttagaattaa agctaaaaac ttaataagag taattaaata tcatgtttta ggaggattaa
     8461 ctttatgata atggatttta ttaaaaaaat tcctgcaggt atgatgatag tgccaatgtt
     8521 tatagcagct ttcattaata ccttttgccc agatattgta caaataggtt cgtttacgac
     8581 agcagtattt tcaagtgttg ggtctgcaac tataattggg gttcaactgg tatgcttggg
     8641 aactcagctt caatttagag aaatgccaaa agttttaaag agaggtggta tacttcttgg
     8701 ttctaaattt gctataggtg ctttgatagg tatacttata ggaaagctat ttggaatgga
     8761 tggtgtcctt ggtcttacaa cattggctgt tataagtgca gttacaaata gtaatggtag
     8821 tatatatctt tcattgatga cttcatatgg agatgaaaca gattgtgcaa ctatgagttt
     8881 acttacttta aatgatggac cattttttac attaatagct cttgggactt caggtcttgc
     8941 aaatgtacca ttgttgtcat tattggctgc aatagtgcca atacttgttg gtatgataat
     9001 aggaaatttt gacaaaaaaa tgaaagagtt tttagagcca gggtgtaatt tactcgtacc
     9061 ttttgtaggg tttgcacttg gtagtagcat aaatcttgca agtatactaa aaggaggttt
     9121 atcaggagta ttacttggat taatatctgt atttgtagga ggtatattta tagtattctg
     9181 tgataaattt ataggaaaac gtccaggata tgcaggatgg gctgtagcta caactgctgg
     9241 aaatgcaatt gctgtacctg ctgctgttgc attagttgac ccatcatggc aaccatatgt
     9301 tgcaacagct acaacacaag tggcagccgc agtagttgtc actgcaatat tagtacctct
     9361 tataactagt tggtgggcta agaagtatgg atgtcctaag ttcccaaaac aaaatgagga
     9421 tggtacaata acagcttaat ttatattaca gtgagttgtt ggtaaaataa taaattcttt
     9481 aattagattt taggatatta ataaaattat attatttata aaggagagca agaataatga
     9541 taaatgcagt gataattgat gaaaaagata atgttgcagt agctattgaa gcaatagcta
     9601 aaggtagtga aattagtttt aaattaaaag acaaaacagt aaaaacgatt acagcactag
     9661 atgatataac tatttatcat aaattggcta taaaagatat ggcccaaggt gataaagtta
     9721 ctaaatatgg tgaacatata ggagaagcaa atcaggagat aaaaagtggt caacatgtac
     9781 atattcataa tgttagaagt gttagagagg atttggataa acaagttatg actaatatat
     9841 aaaataatat ttatagagtt ataaaagttg tattcattga ttttagtgtc aaatagtttt
     9901 taaataggtt tttagctgtt tgattagtga gtgtaataaa aattataata tataaaaatt
     9961 atagaaagta tatagactat tttaggagga aatcagtatg aaattttatg gatataaaag
    10021 accagatgga agagttggta taagaaacca catattaata ttgcctacga gtgtgtgtgc
    10081 atcagataca actagaataa tagcatcaca agttcaaggg gcagttacct ttaataatca
    10141 gaatggatgt tcacaagtac attcagacca acaattaact atggatgtta tggctggtta
    10201 tgcagcaaat ccaaatgtat atggtgtaat agttgtatct ttgggatgcg aaaattgcca
    10261 aaatgatttg gtagttgatg caataaaaga gagaacaaat aagccaataa aaactcttgt
    10321 aatacaagaa gaacatggaa ctttaaaaac tatagaaaaa gctgttcgtt atgctagaga
    10381 aatggcacaa gaagcttctt tgcttagaaa agaagaattt ccaatatctg aacttatact
    10441 aggaactgaa tgtggtgggt ctgacccaac aagtggatta gcagcaaatc cattaatagg
    10501 tgaattaagt gataaacttg tcgatttagg agcaacatca attttaagtg aaactactga
    10561 atttataggt gcagagcata tactagctag gagagcagta aatgaagaag taaaagaaaa
    10621 aatattacat atagtacata gatatgaaaa ttcattaaaa ttggttggag aagaagttag
    10681 agaaggtaat ccatctcctg gaaatatagc tggtggttta acaagtttag aagaaaaatc
    10741 acttggttgt atacataaag gtggtcatag acaaataagt gaagtatatg attatgccaa
    10801 acaaattgat aagaaaggtc ttgttataat ggatacccct ggaaatgatg cttcatctgt
    10861 tgctggtatg gtagcaggag gagcacaaat agtggtattt agtacaggaa gaggaacacc
    10921 atcaggaaat ccaatagcac cagtaataaa aataactgga aataaaataa cttttgcaaa
    10981 tatggaagat aatctggatt ttgatgctag tccagttata tatggtccac aaacaatgga
    11041 agaattaaca gatgatttgt taaatatggt tgtagatgta gcaaatggaa aacaatcaaa
    11101 agcagagtcc cttggatata ctgaaatggc aatagctaga gtatgcaact atgtataatc
    11161 tttaagtaag aaaataaata catagaattt taataaaggg tgagattatg aagtttgtaa
    11221 gttttactga aggagaaaat gaatgtaaaa gaactggagt tttttctaaa gatgaattat
    11281 ttattataga tgttaactct ttaaatctca gtagaaattt taaggattta aatgaattaa
    11341 ttcaaaatgt atctagtgaa gatattatta agttgaaaac tattataaat gaaagtacat
    11401 tctataatta tgatgttttt aaaagagaga gatgtactgt acatgttcct atagaaaaac
    11461 caatacatga tatcttatgt gtgggagtga actataaaga ccatcttgaa gaaactcaaa
    11521 ctcactttga tgatagtttt gaagaaccac aaaaaacggt ttattttaca aaacgtgtga
    11581 caaaggcaat aggtccagaa gatgagatag atggtcattt tgagataaat aatcaactag
    11641 actatgaagt tgaacttgga gtagtaatag gtaaaacagg tgttaatatt agaaaagaag
    11701 aggtagaaga ttatatcttt ggttacactg ttataaatga tatttctgct agaaagttgc
    11761 aaaaagaaca tgttcaatgg tttagaggaa aaggattaga tacatttacc tctttaggtc
    11821 catgtatttt acataaaagt gcagttcctt ttcccataaa acttaaagta tgtagtaggg
    11881 taaatggtga agaaagacaa agttctaata cagggttatt catatcagac gtttcagaca
    11941 tagtttcaga actttcaaaa ggtatgactt tagaggctgg agacattata gctactggaa
    12001 caccttctgg agtagggatg ggattttcac ctcctcgata tatgagtagt ggagatgtag
    12061 ttgaatgtga gattgagagt attggaattt taaaaaatta cattaagtaa ctgttttaat
    12121 ataattaata ttaaagctaa atctgatgta ttaatgaaca tattaaaata aattttagga
    12181 gtttaaatta tgaaagcaga atttttgaca ccagttgtta caatatttga tgaagaagga
    12241 aatttagata aagaaggtaa taaaaaagtg tatgaccatc ttatagatgg aggtgtagat
    12301 ggactagtca taatgggaag tactggagag ttctttaata tgtctatgga tatgcaaaaa
    12361 gaacttatag atttagtaac tagtcatgta aataagagag taaaagtgtt tataggtaca
    12421 agtcgtatgt gtataaatga atctatagaa ctttcaaact atgcacataa tagtggagca
    12481 gatggtgtta tgataataag cccttattat ttctctcttg atgatgatag tattgagtta
    12541 ttttatagtg aaatagctaa gaatacagag gctgaaatat atttgtacaa ttatccagat
    12601 agaactggtt atgatttaag tccagaactt acattaagac ttgcaagaaa acataaaaac
    12661 atagttggat ataaggatac agtaactttg atgggacata ccagagattt aataaatact
    12721 atgaaaatag agttcccaga atttaaggtt tatagtggtt atgatgaaaa ctttatacat
    12781 aatctaatgt ctgggggagc aggttgtata ggggggttat caaatttaat tccagaagtt
    12841 tgctccaaat gggctgaagc ttacaataat agagatatgg agaaggttat agaaattcaa
    12901 aaatatatta ataaagcaat ggatttttac ttaataacca atccatttat accagcaatg
    12961 aaaaaagcta tgaatatcag agggttacaa ataagtgatt atatgactgc tccatttgta
    13021 aaaccaaatg aaaaacaagt atgtgaaatt aaaaaattga tgaatgaatt aaatatatgt
    13081 taaatcaacc ttgcaaagag gtcaacaata aattacaatt atcttaataa aaattaaatt
    13141 aaaataatac tagggtacta tattagttta atagggaaag tgatgaaaat tcactacagc
    13201 ccccgctact gtatacggat acgaaatcaa aatccactga aatttataaa aattttggga
    13261 agggtgatgg aggaaaagcc gtgagtcagg agacctgccc agtattatat aagttcaatt
    13321 tagggtggag attgtaattt ataataaaat gaagtatcaa ttcgtttttg taaagttgat
    13381 atatgaactt ctccttatta aattaggaga agttttttat tttattaaaa ggttatactt
    13441 attaaagatg actttaggat aactttaata agtatacttt aaaaagcata tattattaaa
    13501 gttttttagc cactcataaa aaataagata ttggagtgaa agagatgaaa tttaaatcaa
    13561 atgttttaaa gcagtttttt ttaattgcta tggtaatttt tatggtagga ggtcttatag
    13621 ggtgtagtaa aagtgacaaa gagaataaac aagctagtac tggtaagaaa ttagaattaa
    13681 aatatgctag tggatttagt gttgaagatt tagaagatgg aattaaaaaa gtaactgatg
    13741 gagataatcg agaactgatt ttaatcccaa agaagattaa aattcctgaa aaatataaaa
    13801 atgctaatat agttagaacg cctgtggaca atgtattaat agcatctaca acacaggctt
    13861 gttctctaag aacaatagat gaactagata gtataaaagc cgtaacaaca caagagcagt
    13921 actggactat taaagaaatt aaagatttaa tgaaagatgg aaaaatacat tacgttggtt
    13981 caaatttagc accagattat gaaaaaatag tagacttaaa tcctgactta actatagtga
    14041 gtagtggttt atcagaggct gatacaaaat ttattgacaa attaaaagaa ttagggctta
    14101 attatgttgt agacaatgag tataaagagc aaaatccatt tggaagaatg gagtggacaa
    14161 gtttaatagc tgcattttat gataaagaag atatggctac tagtgaacta aataaaactg
    14221 tacaaaaggt agaagaagta agtaaaaaaa taaaaaacaa agctaaacct aaagttgtat
    14281 gggcatctgt atatgaagga agtgcttata tagctcctaa agattcatat gtggataata
    14341 tgataaaaat ggctggtgga ataaatgcat gtgcttcaat agattcaaat gaagggcgag
    14401 taagtattga acaattgcat gaagttgcaa aagatgcaga tatatttgta tactcatcaa
    14461 gttcagatta tgcaccaaat ttagattcta taaaatctag tgcacctgta ttggctgatt
    14521 tggatgttgt aaaaaacggg aacctatggg tgtttgctcc agattattat caatcagtag
    14581 ataagacaga cgaattaata gtagatttag ttgagatgtt ccacccaggt actacaggtg
    14641 aaaaaatcaa acattatata aattatgata aatagtacag agaggacaca aaaagatagg
    14701 ttttatagat tttagttaat atagctttgc taaaaggagt atacaaatgg attttatcaa
    14761 taaaatgaga ataaggaata cgacaatatt tatagtatta attataagta tgatacttac
    14821 ttttttagtg tgtgtagcat ttggctctgt aaaaattgaa tttaaagaag taatagatgt
    14881 tgtattaaga ggtatggata atacagaaca ttataaaata atatacaata taagaatccc
    14941 tagagtactt gcaaccatgg taggtggagc atgcctagca gtatcaggta ttttattaca
    15001 gatatttttt aaaaacccaa tagttgaacc gtatatatta ggagtatctt caggttctac
    15061 tttatcagta gctctcatga ttttgggagg atacacattg ggatttgaga gtgtaaattc
    15121 aatgagtata tttgtagcag cttttatagg agctttaatt gtaatgtcta tagtcatttt
    15181 atttgcaaat aaggtaaaga atataacaac tcttttaata ataggaatta tgaccggata
    15241 tgtatgtagt ggtataacaa atgtgttaca atcatttgca aatagtgata aattaaaaga
    15301 atttactatg tggtctatgg gaagtttttc tggatttaca tgggaaaagg tagaaatact
    15361 tataatagtt ggtatattag gtcttttgat gactgtattc ataataaaac ctttaaatgc
    15421 ttttttacta ggagaagagt atgcaaaaag tattggcata aatataagat tttttagagt
    15481 tttgatagta tttatatcta gtatattagc agcaatagta tcagcatttg caggacctat
    15541 agggtttatt ggacttgcag tgccacaaat ttcaaaaatg atatttaaaa catcagataa
    15601 tagagttttg ataccagtag taatattttt aggcagtata gttacagctc tttgtgattt
    15661 aatatcaaga gtaattttat caccagtaga attaccaata agtacaataa catctttatt
    15721 aggagctcca attgtagtaa tgttattggt gaaaaggaag gatagggctt agacatgttg
    15781 aaaactaata atttaagtgt aggatacaat aacaaagttg ttataagtaa tataaatgta
    15841 gaagtaaaaa atggagaaat actatgtctt ttgggaagta atggagctgg aaaaactacc
    15901 ctattaaggt ccttatctaa acttatatca ccaataaaag gtgaaatata tttgaatggt
    15961 gtaaacataa attgtatatc aagaaaagca ttatcaaaaa aaatggcttt agtacttaca
    16021 aatagattat taggtgattt aatgactgta caagatatag tcaatatagg aaggtatcca
    16081 tatacaggat tttttgggag tctatctaag aaagatttaa taatggtaga tgaagcattg
    16141 gagtctgtag atgccttaca tttaaagaaa agatattttg atgaactaag tgatggagaa
    16201 aaacaaaagg tgttggttgc aagggctctt gttcaagaac cagaaataat tatattagat
    16261 gagcctacaa ctcacttgga tataaaacat agattggaac tcataaacat actgaaaaaa
    16321 ttaagtaaag aaaagtcaat atcagtaata ctttcattgc atgaaataga catagcatta
    16381 aaaagttgtg ataaagttgc tcttataaaa aataataaag tcatagctta tggccagcct
    16441 gaagatgtag tagatgagga tattataaat tcgctttatg aattggatga taaaaacttt
    16501 aatagtcttt taggttcagt agaaattagt aataaatcta aaaatgaagt ttttataatt
    16561 ggtggtgggg gtaaagcaac accaatttat agagctttta ctaaaaaagg tataggtctg
    16621 tattctggaa taatacatga aaatgatatt gattatgaaa ttggtagaac tatggggata
    16681 aagatgttta cagaaaatcc atttgagcct ataagtgatg agagtttcga tttggctatt
    16741 agaaatttaa atgattccaa gattataata gatacaggat ttagtgtagg agagacaaat
    16801 aagaggaata tagatattat aaaagaagct ttaaaattgg ataaaaaagt ttattctttt
    16861 agaaatagag atgagagtaa gaagtattat gacagtttgg atagtaagat agaacatata
    16921 gataaagttt ctcaaataat caatagtgca gatataaata atttattata atttatgaaa
    16981 taaaatgtac ttatgtgtta tagaaaaaag agtatagatt ataatttttt tgaaattaca
    17041 atctatactc ttttgttatt ttgtttatgt atttatatat ttataaaact ttagcatttt
    17101 atagataacc aatagcttcc tctctagtta aaaaaaagtg aatccctgta gtcgattctt
    17161 tccatctatt ttcattaaaa tcttcagcta caatcgtttc tcctactcta tatataaaat
    17221 tttcatcagc atatgcacga gcacttttaa aagattcttt accatctaca ctagtaattg
    17281 acagtacttt tgccttatca catctacaag catttgatgt agcagacact ctttttgcgt
    17341 cgctgggtat taataattgt accattctaa aattaaaaca ttttttatag cctataaatg
    17401 ctcctgtttc aggacaatac aatttaaaaa aacgagtact ttcatctgat attactccat
    17461 ttaaagtagc atattctaaa ttggaatttt ctaaattagc tcctctaata tctgagttag
    17521 ataagtcaca aaatctaaaa cttgcaccac ttaagtctgc attttttaat atagaatttt
    17581 ttaatgaaca atccgaaaga taagaattat taaaaataga gttttctaaa tctgcttttt
    17641 ctaaatttaa attgataagg tcagaccacg aaaagtcaat attacttaag cagtatcctc
    17701 ttaagtccat attttctaat cttaattctt ttaaatctgc cttttctcca gcattattgt
    17761 ttttaagcca taaataatgt ttctcaagtg ttttttctaa ttcttgttta gaaatagttt
    17821 tcattaaaat caccttcata aatttatttt tatatatgta gtagcaaaat agtcatatat
    17881 ttaattatat aacaataaat aaaaaacttc taaataatat ataaaatatc atcttgaaag
    17941 tacttttttc aatatatcag aatatatttt taagctattt agagataatt taaattttta
    18001 aacaggacat aataagcttg tattgtttta tatttgagtt gataaaaatt tctttaaata
    18061 aaaataatgt caattataaa gtaataaaag tttagatata aaaaaatttg tgtatatact
    18121 atatgtagta tataatagat aaagcactga ctatatgtag tgcttttgtt tttgaaaaat
    18181 acttattgca tttctataat tatagattaa ttttgggatt tcaactgata agtaccaaaa
    18241 gaaataataa gcaaattaag tgaaattatg gcacaagatt atgttaaaag gacggtaaat
    18301 aatgaattgg atagagctta acaatcaagt gataattaaa aatgaacaag gcaagtacca
    18361 attggaaaag gataaggaag ccttaagtag ttacatagaa gaatttatac agccaaagtt
    18421 gagaaaattt aataacctag aagaaagatt gaagtattta atagatgaag gttattattc
    18481 aaaagaagta ataaatcagt atagcataga tgttattaaa aatatatatg atatgattga
    18541 taaacataag tttgaatttc aatcatatat gagtgcaaat aagttttatc aaaattatgc
    18601 attaaagagc aatgatggaa aggaaatatt agaaacatat aatgataaag tgttaattgt
    18661 agctttgaca ctaggaaatg gcgataaaga tttagcttta aacttggcag ataaaatagt
    18721 aaaacaagaa tttcaaccag ctacacctac ttttttaaat gctggaagaa aaagggctgg
    18781 agaaatggta tcatgttttt tactatctgt agaagatagt acagaaggta tatcgtatgc
    18841 tatatcttca tcaaatcact tatcaaagat tggtggagga gttgcactaa atttatctaa
    18901 acttagagca tctggcgaat ctatcaaaga tatagaaggt gcagctggag gtgttgttgg
    18961 agtagctaaa atgttagaac aatcatttag ttactttaat caaatgggag ctagacaagg
    19021 ttctggtgcg gtgtacctta ctgtattcca tcctgatttt gaattgttga tggatactaa
    19081 aaagataaat gcagatgaaa aaataaggct tgctacatta tcattaggag ctataatacc
    19141 agataaattt atggagttgg cagaaaaaaa tgaagtagca tatgcatttt atcctcatac
    19201 tgtgtataag aaatatggag tttctcttga tgagatagaa atggataagt ggtatgataa
    19261 actggttaat gatagtgata taagaaaaaa agaaataaat cctaggcaga tgttgacaaa
    19321 aatagcacag atgcaacaag aaagtggata tccatatgta gtgtacatag atacagctaa
    19381 tagagaacat acattaaaag atgttggaat tattaaaatg tctaacttat gttgtgagat
    19441 atttcaatat caaacacctt cagaaataga ggggtatgga ggaaaaaatg aatggggaca
    19501 agatataagt tgtaacctag gttctttaaa catagccaat gtaatggata ataaaactat
    19561 agaaagtaca gttgaaacag caataagagc actgtcattt gtagcagata gcacagatat
    19621 aaaaccagtg ccaacggtaa gcaatagtaa cagcaagtct cattctatag gattaggagc
    19681 tatgaattta catggatact tagtaagaga aaatatttta tatacttcag atgatgctat
    19741 agatttttct aatgtatttt ttgcaatggt tagatactat tcaattaaag cttctatgaa
    19801 aatagctata gaaagaaatc aaacttttga aggatttgat aaatcagaat atgttaaggg
    19861 aagaaatagc aaggttttat caaaatacta tgaacaatct tatctaccta agtcagaaaa
    19921 ggtaagagca ttatttgaag ggatttatat accaacaaaa gaagactgga caaaattatt
    19981 ggatgaggta aaagaaaaag ggatatataa tgcatattta atggcagtag caccaactca
    20041 aagcattagt tatgttcaaa atgctacatc aagtataatg ccaattactg agccagtaga
    20101 agtaagaaca tatggagact ctactacaat atatccaatg ccatttttaa caaatgataa
    20161 tatgttgtat tatcaatcag catacaggat ggatatgaga aaggtcatag atttagtggc
    20221 aacagttcaa aaccatgttg accaaggtat atcaacaaca ctgtttgtta cagatgaaaa
    20281 gacaactaga gatatagcta gacattacat atatgcctat aaaaaaggtt tgaaaagttt
    20341 atattacaca agaacaaaga tgacaagaga tactcatgag tgtctagtgt gttcagtata
    20401 gggagagaaa tatatgacat ttaatttaca taaaatacat aatgcagtta actggaatag
    20461 agaagaagat ggatttacac aagctttttg ggaacaaaat gtaaaacaat tttggcttcc
    20521 tgaagaaata tctgtttcta aagacataaa ggtatggaat gaactaagta ataaagaaaa
    20581 ggaattatat aaaaaagtat tgggtggttt aacattactg gatacaaaac aggggaataa
    20641 tggaatacca tctatgatga gtttaacaga aaacctacaa agaaaagctg tcttgtcttt
    20701 tatggggact atggaagaaa tacatgcaaa aagttattct tctatattta tgactctact
    20761 ttctaattta gaaatagatg aattatttga atggatagaa acagaaccaa cattacaaag
    20821 aaaggctgat ttagttttag ctcaatacga aaatactaca aatcaagagg gattatacct
    20881 atcaatggtt acaagtgtat ttttagagag tttcttgttt tattcaggat tcttttatcc
    20941 attgtatcta tctggtcaag gaaagatggt agctagtgga gaaataatat cgcttattct
    21001 tagagatgag tctttacatg gtaagtatat aggattgcta gcacaagaaa tatacgattc
    21061 atttgataaa atggataagg agatgttaga agagaagatg tattctatac tttatagcct
    21121 tatggagaat gagatagagt atacaaatgt tatatacaga gaaagtgggc ttgaaaaaga
    21181 ggttgtgaac tttttaaaat acaatgcgaa tagagcttta gaaaatctag ggtttgagaa
    21241 gctatatact gtagatgcta taaatccaat tgtattaaat ggtcttagca ctgaaaccaa
    21301 aacacatgat tttttttcaa ctaagggtaa tggataccaa aaaggagtgt atgaggaatt
    21361 agaggatgaa gattttataa tataatttat aattatgaca cactgttgtc acttttagcg
    21421 tgataatatc aatgtataaa atatatatgg aggtattttt atgaaatatg aatggagaaa
    21481 aagagataaa gagttatatt tacctaaaaa gaatcctgta atagttgaaa taccagaaca
    21541 gaaatttatc atgttaaaag ggagtggaga cccaaattct aaagaattta ctgaagcaat
    21601 aggagtactt tattctttgg catatgcaat aaaaaccatg cctaaaaaag gaattgtacc
    21661 agaagggtat tttgactata cggtttttcc tttagaaggt atatgggata agggagaaaa
    21721 aagtaaaggc ttagatgtac ttattaaaga agatttaatt tacactataa tgatacgtca
    21781 gccagatttt gttacacaag acctgttgga taaagctact gatatagtaa agaagaaaaa
    21841 acctcataat cttcttgaaa aagttagatt tgggtctatt aatgaagggc tatgtgttca
    21901 aatgcttcat ataggttcat atgataatga accagaaagc tttgacatta tgaacgaatt
    21961 ttgcaaaaaa aataaactta taagaaaatc ttacacacat cgtgaaattt atataagtga
    22021 tgctagaaaa gtatcgcctg aatcattgaa gacggtttta cgttttgaag tagaaaggga
    22081 agtataaata ttttgaataa tttataagag ttataaaaag tgaagtctgt tgagacttca
    22141 ttttttgatg caattttaaa attaaatttg atgtttcata atattttaaa aactttctac
    22201 ttttattagt gtgaataact gttgctatta aataataata ctaattatat aagtattatt
    22261 atataatatt tatagattat tatataaata gat
//
LOCUS       DAEHWM010000069        22178 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.070, whole genome shotgun sequence.
ACCESSION   DAEHWM010000069 DAEHWM010000000
VERSION     DAEHWM010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22178)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22178)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22178
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.070"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            164..505
                     /locus_tag="KNP36_002583"
     CDS             164..505
                     /locus_tag="KNP36_002583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator"
                     /protein_id="HBF0874444.1"
                     /translation="MKEENFINVEYEDKRFSINSKEVLYIEKQEYEVKIYTESGNYEV
                     GENAPCIRKLLKEENFFKCSNSYIVNLDKCEFYLSNNCIFVNNNFIRILGSERKKKLK
                     KKLEKLYDYED"
     gene            656..1069
                     /locus_tag="KNP36_002584"
     CDS             656..1069
                     /locus_tag="KNP36_002584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897017.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1653 domain-containing protein"
                     /protein_id="HBF0874445.1"
                     /translation="MLELKNNLGISERKLKYPCIYKHFKGKYYATMGLSKAIDDIENI
                     CEIYGKENLIQNRNKYKLVIRHTEREEDIYVYRDLDGNFYHKKEEDTNDLVLYKTLYD
                     DTGIFARPLDMFLEKVDTDKYVNSIQEYRFEEVYK"
     gene            1271..1912
                     /locus_tag="KNP36_002585"
     CDS             1271..1912
                     /locus_tag="KNP36_002585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HBF0874446.1"
                     /translation="MGNTFYIVRHGQTDWNILGKTQGHGNSDLTPQGIEQAKELSEDI
                     GKYSIDYIFSSDLGRAMQTAQILGDKLNIEVQKTEALREMGFGVWEGLLIKEIQKDYS
                     DIYATWRNEPHLVNIPEGETLKIIKERVDAFIKELNEKYDNKNIILVTHSITLRVMLL
                     SFLESGMENIYRIKQDNTALNIVEFKDYGPVIVKMNDTSHIKNHVKINNSALE"
     gene            1936..3189
                     /locus_tag="KNP36_002586"
     CDS             1936..3189
                     /locus_tag="KNP36_002586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBF0874447.1"
                     /translation="MSKVIVVGGGASGMMAALSASKNNNEVILVERNGELGRKLRATG
                     GGRCNFTNNREIEDFFDKVVSNKKFLYSSFYTFTNKDLISYFESRNLEYKIEEENDHK
                     VYTKNDKSIEVIEVLNKDLLNHNVKIMYNKKVIDIITEEIALKDDSNKDKSKYLIKGI
                     ILDNGDKILGDKVIISTGGVSYSKTGSDGSMYKILKKHGHTLNKLYPALVPLTIEEKW
                     IKDLQGISMKNVEISCKIKKRKISKSGDMLFAHFGITGPCVLIMSSYINKIIEKEKVE
                     LNIDFLPNLNTDEISSIIRAFPNKNVLNNLKQILPQNFLKEIFSLLSLVDKKASDLSK
                     ADEIRIIEYIKNMKLTCNGTTGINTGMVTSGGISVKEINSSTMESKLVKNLFFTGEVI
                     DIDAETGGYNLQIAFSTGYLAGISV"
     gene            3235..3885
                     /locus_tag="KNP36_002587"
     CDS             3235..3885
                     /locus_tag="KNP36_002587"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HBF0874448.1"
                     /translation="MGNLVIAVDGPAGAGKSTIAKIVAKKLNINYIDTGAMYRAVTYK
                     CLKSGIDVNNEKEVIQIAENSDIDFKDNNIYLDKEVINEEIRTIEVSNNVSNVAKIKE
                     VRQLMVEVQRKIGMKNSVILDGRDIGSYVFPDADYKFFLVATPEERGNRRYKELCNKG
                     YNTTLEEVIEDIIRRDEIDSNREFAPLVKANDALEIDTTGKTIEEVVEEVVSKINL"
     gene            3936..4532
                     /locus_tag="KNP36_002588"
     CDS             3936..4532
                     /locus_tag="KNP36_002588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HBF0874449.1"
                     /translation="MNFYRFVINIFKGFSKIFFKYEVIGAENIPDRGNIVIASNHKSN
                     LDPIFLAAAIENREIAAIAKKELFKVKPLGFILKKLHVMPINREKPDVSTIKTILRSV
                     RDGYVLGIFPEGTRIKGDSFGKAKAGLSVFTIKSKSKVVPVSIISKYKLFSKVIVYIG
                     EPISFEEHFKEKLSNDDHERISQEILEVIKQNYFKYSK"
     gene            4545..5384
                     /locus_tag="KNP36_002589"
     CDS             4545..5384
                     /locus_tag="KNP36_002589"
                     /EC_number="1.17.7.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="HBF0874450.1"
                     /translation="MNIKIAKNAGFCFGVKRAMKMAWDEVEKNDSGIYALGPLIHNKQ
                     AVAKYEEKGLKTVNEIDTIPNHENMIIRSHGVPENIYKEAKDKKLKIVDTTCPFVKKI
                     HTVVSEYHNKGYEIIVIGDMKHPEVIGINGWCENSAIIIKTLEQMENMEFDNSKRYCL
                     VAQTTINPELYISIVNKLSDKLEEIVFNDTICSATKTRQESAKELAKEVDCMIVIGGK
                     HSSNTQKLVKVCEDLVPTFAIETKDELDVNTLKKYKNLGITAGASTPNWIIEEVVTFL
                     ENL"
     gene            5629..6783
                     /locus_tag="KNP36_002590"
     CDS             5629..6783
                     /locus_tag="KNP36_002590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenic efflux protein"
                     /protein_id="HBF0874451.1"
                     /translation="MEMLISASEEAFLHVGSMIGFFILLFGYINYKTSGNFTNIISKN
                     RKFQPLIGALIGAIPGCGGSLAIMPLYINGKLSFGAIIASLIASMGDAAFVLISSNIK
                     MYFFVTIVSTITGIITGQLVDYFKLEEKLGLKNRRKSDKYDISKNNPKENKEQHNHDE
                     IILDTLAKSHGNTNRLAFIITHGKGYKIYIGIIVIGFIFMSLAHSGLNLPIIEKLHSL
                     EEVIAVIGILFSIIYMWCFKKVFKNSNQKEEENKKISLREMLIHSVGEISFVITWIFI
                     AYLIYDLIILILGGDEYLVKLVLSTGVISVFIGAGLGLIPGCGIQIVLMSFYLKGTIP
                     LGAVIANSISQDGDALFPLLAMDKKSSLWAMIITTIPAILVGMIVYAFLG"
     gene            7089..8786
                     /gene="ade"
                     /locus_tag="KNP36_002591"
     CDS             7089..8786
                     /gene="ade"
                     /locus_tag="KNP36_002591"
                     /EC_number="3.5.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine deaminase"
                     /protein_id="HBF0874452.1"
                     /translation="MGNLKRQCDVSSGREKADIVLKNGTIINVFTEELITGDVAIVGD
                     TIVGIGDYKGNVEIDCSNKYISPGFIDAHMHIESTMVMPIELSKKLLKSGTTTIIADP
                     HELVNVKGVSAIDFLLESTKDIPLNVYIMVPSSVPATSFETNGVGKFSAKDMESYVNN
                     PRILGLGEVMCFNDVINSENEILDKLELFKNKVVDGHAPNINGKSLQTYVCAGIENDH
                     ECITFDEVYEKLRAGLKILIREGSAAKNLKSIVSGMLKHNLPIEEFMFCTDDKHLDDI
                     EKQGHIRWNIKCAIDLGMEPVRAIKVATYNSAKAYGLRKIGAIGAGYKADIVVLNDLD
                     KMEVDSVYKDGNLVNEEMFSNYNYEIKDKELLNTVKFKYINKEKIQLKVSEKNYVMEI
                     VPYQILTNKVYESLPCADGYFVPNKEYSKLCVVERHRMTGNVAIAPLKGFGIKNGAIA
                     TTVAHDSHNIIVAGDNDDDILVAINYLKEIQGGYVIVSNGKVLAHLSLQVAGLISTFT
                     AEEVQEITDNMLEIARKMEVPEYVDPFITLSFMALPVVPQIRLTDLGLFDVEEFKFI"
     gene            9138..9602
                     /gene="bcp"
                     /locus_tag="KNP36_002592"
     CDS             9138..9602
                     /gene="bcp"
                     /locus_tag="KNP36_002592"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002586316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-dependent thiol peroxidase"
                     /protein_id="HBF0874453.1"
                     /translation="MLSIGTKAPEFTLEDKDGNKVSMSDFKGKKVVVYFYPKDNTPGC
                     TRQACAFRNAYDGFKKEDIQVIGISKDSIKSHQKFAEKHELPFILLSDPDLVAIKAFD
                     VWKEKKMYGKTALGVVRATYIIDENGIIEKVFEKAKPDTNAQEILEYLEKQE"
     gene            9612..10355
                     /gene="yaaA"
                     /locus_tag="KNP36_002593"
     CDS             9612..10355
                     /gene="yaaA"
                     /locus_tag="KNP36_002593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HBF0874454.1"
                     /translation="MIIMLSPAKNMKNIEVFDRDLSLPCFIDNTKEIVENIKTFGIED
                     FKNKMKINEKLAVLNKNRFESIKFDRLGNPAILTYDGIQYKNIEAENFTRKDEEFANS
                     CIRIISGLYGVVKPYDSIYEYRLEMQTKLQVGEFKNLYEYWGNRIYKELIKEKTAIVN
                     LSSNEYSKSIEKFIKDSDTYITCTFKVNKNGILKVESTQAKKARGMMTKYIVKNRIRD
                     IEELKKFDLEGYKYKENLSNNSEYIFVKE"
     gene            10483..13140
                     /locus_tag="KNP36_002594"
     CDS             10483..13140
                     /locus_tag="KNP36_002594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HBF0874455.1"
                     /translation="MENHKQMPWHSRATHEILESLDSSEEGLTDTEAEKRLKENGLNE
                     LRKKPPRTTLQMLWSQITDAMVMILIGAAILSLIFGEFTEAFVILIIVTVNAVIGIVQ
                     EKKAESSLEALKNMNSPTARVMRDGEENVIPASNLVVGDIVFLEDGAMVPADLRLIET
                     SSLKIQEASLTGESVPSEKDADTILPKECVLGDRSNMAYTSSIVTYGRGVGVVVATGM
                     DTEVGNIAHLLDSQDDFDTPIKRKLNTVGKTLSVIGIIVCVVIFAIGAFYQRPLLPMF
                     MIAISLAISIIPEGLPATATIVMALGVQRMAKRNALIRKLPAVETLGGATVICCDKTG
                     TLTLNKMTVTHIAVNGDFESGKVTSIDTASEKHPLVYKEIVYAGALCNDACINPDKTD
                     EILGDPTEGALIFMAKKFGIDQEALEEEYPRVFEQPFDSDRKCMTTVHNIDEKIIAYT
                     KGAVDEILDLCTKILTSKGERNITEVDKKNIHELCLNMSKDALRVLGFAKREISSIPK
                     EDSENIEYDLTFIGMVGMIDPPRTEVIDAVSTCKEAGIRTIMITGDHKVTATTIAHEL
                     GIWSEENTVISGDELDNLSDDELDEAVKNTTVFARVSPFDKLRIIQSLKRIGEVPAMT
                     GDGVNDSPALKSADIGIAMGISGTDVAKDSSDMILMDDSFTTIAYAIKEGRRVYRNIQ
                     KVIQFLLVGNIAEILTLFVAILLNWDTPLLAVHILWVNLATATLPALALGVDPPSRNI
                     MKHQPVKSTTLFEKNLIQRVVTQGIFVAIMTILAYKIGLNIENHSVGQTMAFCVLAFS
                     QMLRAFSQRSNTDSMFNRNNGKNPFLLISFLTSAFLIAVILFVPVFRNAFNLTVLNNL
                     EWLVTIVLAIMSVIQVEVGKIIKRKKLKK"
     regulatory      13194..13296
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            13406..14671
                     /locus_tag="KNP36_002595"
     CDS             13406..14671
                     /locus_tag="KNP36_002595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase"
                     /protein_id="HBF0874456.1"
                     /translation="MYNKETICVQGNYKPGNGEPRVLPLYQSTTFKYSSIDQLAELFD
                     LKVDGHIYSRISNPTIQAFEEKISLLEGGVSSVAVSSGQSANMLAVLNICKSGDSILC
                     SSKVYGGTFNLLGPSLKKFGIDLISFDLDSSEDEIVELAKENTKVVFAETLANPTLEV
                     IDFEKIANVAKRINVPFIVDNSLASPVLCNPLKYGANIVTHSTTKYLDGHASSVGGII
                     VDGGNFNWDNGKFPELVEPDPTYHGISYTQKFGNAAYATKARVQLLRDYGNCLSPFNA
                     YLTNLNVETLHLRMERHSENALKIARFLEKHENVDWINYPGLEDNKYYENAKKYLSRG
                     CSGVLSFGVRGGLENAKKFVEKLQIASLVTHVSDVRTCVIHPASTTHRQLTEEQLIAS
                     GVLPSLIRLSVGIENVEDLIADLNQALNF"
     gene            14701..15591
                     /gene="metA"
                     /locus_tag="KNP36_002596"
     CDS             14701..15591
                     /gene="metA"
                     /locus_tag="KNP36_002596"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HBF0874457.1"
                     /translation="MALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAI
                     LNLMPIKIDTELDLLRRIDKTGFNVSVEFIKISTRESKRSCNEYVKEFYKTFDEAKGE
                     YFDGFIITGAPVEQMEFEEVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVK
                     KLPLSQKCFGVFKHKVDKDSKIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSK
                     EAGPYIITNSRDVFVMGHSEYDKYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTV
                     KWKKHSELLFRNWIKNYLIQ"
     gene            16082..16525
                     /locus_tag="KNP36_002597"
     CDS             16082..16525
                     /locus_tag="KNP36_002597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0874458.1"
                     /translation="MDEMSFKKELLELTRDINMKFTTLLSDFYQPLGITAVQALILSE
                     LCEHGEKKISDLGKNLNMTNSNVSVICQRLEKNGFLNRIRDIEDQRIVKVKVTNKSLD
                     IQEHISSSIFDSYFENMTSEKLQDMEDIIEGLEKLNKLLTYIDCK"
     gene            16556..18373
                     /gene="ftsH"
                     /locus_tag="KNP36_002598"
     CDS             16556..18373
                     /gene="ftsH"
                     /locus_tag="KNP36_002598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HBF0874459.1"
                     /translation="MDEHKPQKRSALYYYTVIIIVVMFLNALIFPSLMDKKMVEIDYG
                     KFLTMLDTGKVKSVEIENNRIAINPSSSKDKNIYITGRMDDPELVDRLKNAKVEFTKV
                     IPKENSPLLSILLTWIIPIGILMLFGNLMMKSMQKRMGGNAMQFGKSNAKMYVSAQSG
                     KRFNDVAGQDEAKEALTEIVDFLHNPEKYKKIGAQMPKGALLVGPPGTGKTLLAKAVA
                     GEANVPFFSISGSEFVEMFVGMGASRIRDLFKQAKEKAPCIVFIDEIDTIGKKRDNGS
                     GLGGNDEREQTLNQLLSEMDGFDGGIGVVILAATNRPDSLDKALLRPGRFDRRIPVEL
                     PDLGGREAILKVHAQNVNVSSDIDYNAIARSTSGASGAELANIVNEAALLAVKSGRDI
                     VEQQDFDESVETVIAGYQRKGAVISDKEKKIIAYHEIGHALVAAMQKHSAPVHKITII
                     PRTSGALGYTMQVAEDESVLMSKEEAIDKITTFTGGRAAEEVIFNTCTSGASNDIEQA
                     TKIARAMVTRLGMSEEFDMVALETVSNQYLGGDTSLACSSDTAAKIDEEVFKIVKACH
                     KNAIEILENNIDKLHELANYLLEKETITGDEFMEILNLN"
     gene            18551..21253
                     /locus_tag="KNP36_002599"
     CDS             18551..21253
                     /locus_tag="KNP36_002599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase KdpD"
                     /protein_id="HBF0874460.1"
                     /translation="MDRPNPDILLEKIKNEEEKLSRGQLKIFFGYAAGVGKTYSMLES
                     AQNLKKVGVDVVVGYIEPHTRPETLALLDGLEILPVKEIEYKSIKLKEFDLDAALARK
                     PEVILVDEFAHSNVAGLRHTKRWQDIEELLLAGINVYTTVNVQHLESLNDIVEIITNV
                     SVKETIPDKFLDTNTQLELIDVEPDVLLERFNEGKIYKKEQATRAKNNFFIKDNLVAL
                     REIALRKTAERVNKEVQMTRLSKGDVTVIPTSDTLLACISPSPSSAKVIRTASRISDS
                     TFAKWIALYVETPNTARLPFDEQKQLQNNLKLAKKLGGEIIVLHGENIIEQILRIAKL
                     RNVTKIVIGRNHSSNKRFSKRFKKDIVDKLIDEVDYIDIHIIPYKFASDVKYKPKKDK
                     SSIKSKFKISKVDFIKLIFITLMISILAYAVQSMGFIRENILLIYMLGVVLVSMWTKG
                     YSTGIISSVFNIVLLNYFFTAPLYTLSIADSNYIVTLVVFSIVGIITSTLTSKIQHEA
                     ETAAKREENTKMIYQIIKGFLRLSNKDDIVNKGIELLSLSLSRDVICYLNVDKHNKSK
                     LYKKNTNNKDKNDLDSEDEKAVASWVLSNSTVAGNDTDTLPGSKGYYIPIVGMNLTLG
                     VVGISCIDSKLDTEDISLIETIIAQMAIALDREILSEAKENTNLEIERERLRSNLLRA
                     VSHDLRTPLAGISGAVSTIIKNKGTIGQDIIDELLSGVYEDTQWLIRLVENLLSMTKI
                     DEGKLEVKKHSELVEEIISEALQKIKKRIENALIDINIPEQILFVPMDAKLIEQVLIN
                     LIDNSLKYSKEDCKIEINVYEKDDYVWFEVSDNGPGISKELKKHIFDRFFTGEEGAKD
                     SRKGVGLGLSICKSIIQAHKGEIMVENNKDKGSTFKFSLPKENE"
     gene            21287..21985
                     /locus_tag="KNP36_002600"
     CDS             21287..21985
                     /locus_tag="KNP36_002600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874461.1"
                     /translation="MSKKLILLVEDDKTIRKFISTALLTQDYDVKEAITGKEGISIAV
                     SYSPDVVLLDLGLEDMDGIEVIKAIRQFSNIPIIVVSAREQDRDKVEVFDAGADDYLT
                     KPFSIVELLARVRVAFRHSQVEAQQKDDVKSTFEVDKLLIDFDKRKVIVDDVEVHLTP
                     IEYNILSLLAKYHGKVLTHNFIIKEIWGSVIGNETKSLRVFMATLRRKIEKQPANPRY
                     IITEVGVGYRLNDE"
BASE COUNT         8868 a         2370 c         3981 g         6959 t
ORIGIN      
        1 ctttttaact ttaaaaatta atgttaaaaa ataaacttat acattaatat taataataat
       61 tatttaaata tcttaagtaa atcagtctta catatatttc cgatagatta tattgataaa
      121 aaacactaaa attaaattaa taaaagtact tggagggatg gaaatgaaag aggaaaattt
      181 tattaatgtt gaatacgagg ataaacgttt ttcaattaat agtaaagaag ttttgtacat
      241 agaaaagcaa gagtatgaag taaagattta tactgaaagt ggtaattatg aagttggaga
      301 aaatgctcct tgtataagaa aactattgaa agaagaaaat tttttcaaat gcagtaatag
      361 ttatattgta aatctagaca agtgtgaatt ttatctcagc aataattgta tttttgtgaa
      421 taataatttt ataagaattt taggttcaga aagaaaaaag aaattaaaaa agaaattaga
      481 aaaattatat gattatgaag attaatattg ggaggctgta ttttatacag cctctttatt
      541 tattgattgt attattaata aattttaaat tatgataaaa tataaaacaa gtaacttatt
      601 tcagaataaa atacttttta aaagaaaggg acgagatatg ggagattata ataaaatgct
      661 tgaattaaag aataacttag gtatcagtga aagaaagtta aaatatcctt gtatctataa
      721 acatttcaaa gggaaatatt atgctacaat gggtcttagc aaggctattg atgatataga
      781 aaacatatgt gaaatatatg gtaaagaaaa tttaatccaa aacagaaata aatataaatt
      841 agttattaga catactgaaa gagaagaaga tatctatgtt tatagggatt tagatggaaa
      901 cttttatcat aaaaaagaag aagatactaa tgatttagtt ttatacaaga ccttatatga
      961 tgatacagga atatttgcaa gacctttgga tatgttttta gaaaaagtag atacagataa
     1021 gtatgtcaat tcaattcaag aatacagatt tgaagaagta tataaataat ataagagaaa
     1081 tatgtttata aatttagaaa aattctttaa cagtacaata atttgcagaa atacaaatga
     1141 gatttattgt aaataatatg ttagattaga ttataaaata gaaacaaagt aaagtattat
     1201 atgatataat taagttttga gaagtgataa tttatattta ataaaaaata ggcatatatt
     1261 aggaggacat atgggaaata ctttttatat agtaagacat ggacaaacgg attggaatat
     1321 attgggaaaa acacaaggtc atggtaattc tgaccttacg cctcaaggta tagaacaggc
     1381 aaaagaactt tctgaagata ttggcaagta ttcaattgat tatattttta gtagcgacct
     1441 tgggagagca atgcaaacag ctcaaatttt aggagataag ctcaatattg aagttcaaaa
     1501 aactgaggca cttagagaaa tgggattcgg agtttgggaa ggccttttaa taaaagaaat
     1561 tcaaaaagat tattcagata tatatgcaac atggagaaat gaaccacact tagtaaatat
     1621 accagaaggc gaaactctta agattataaa ggaaagagta gatgctttta taaaggaact
     1681 aaatgaaaaa tatgataata aaaatataat tcttgttaca cattcaatta cattgagggt
     1741 tatgttgttg tcatttttag aatcaggtat ggaaaatata tatagaatta agcaagataa
     1801 tactgcttta aatatagtag aatttaaaga ttatgggcct gttatagtaa aaatgaatga
     1861 tacaagtcat ataaaaaatc atgtaaagat aaataattct gcactggagt aggaatcaat
     1921 tataaggaga aatttatgag taaagttata gtagttggtg gaggagcttc tggaatgatg
     1981 gcagctttgt cagcttcaaa aaacaataat gaagtaatat tagttgagag aaatggagaa
     2041 ttaggaagaa aacttagggc aactggtggc ggtagatgca attttaccaa taatagagag
     2101 atagaagatt tttttgataa agttgtcagt aataaaaaat ttctctatag tagtttttat
     2161 acatttacaa ataaagacct tatttcgtat tttgaaagta gaaatttgga atataagatt
     2221 gaagaagaaa atgaccacaa agtatacact aaaaatgata aatctataga agtaatagaa
     2281 gtattaaata aagatttact caatcacaat gtaaagataa tgtataataa gaaagttata
     2341 gatattataa ctgaagaaat tgctctaaaa gatgattcta ataaggacaa gtcaaagtat
     2401 ctaataaaag ggattatttt agataatgga gataaaatac taggagacaa ggttattata
     2461 tcaactggag gagtgagtta ttcaaagacg ggttcagatg gttcaatgta taagattctt
     2521 aaaaagcatg gacatacatt aaacaaacta tatcctgctt tagttccact tacaatagag
     2581 gaaaaatgga ttaaagattt acaaggaata tccatgaaga atgtggaaat atcttgtaag
     2641 attaagaaaa ggaaaatatc aaaatctgga gacatgctat ttgcccattt tgggataaca
     2701 ggaccttgtg ttcttataat gtcttcttat attaacaaga ttattgaaaa ggaaaaggta
     2761 gaattaaata tagatttctt accaaattta aatactgatg aaatctctag tataatcaga
     2821 gcatttccaa ataaaaatgt tctaaataat cttaagcaaa tactacctca aaatttctta
     2881 aaagagattt tttctctatt atctttagtt gataaaaagg caagtgattt gtctaaggca
     2941 gatgaaatta gaattattga gtatataaaa aatatgaagc taacttgtaa tgggactaca
     3001 ggtataaaca ctggtatggt tacttctggt ggtatttcag ttaaagaaat taattcttct
     3061 actatggaat ctaaattagt taagaactta ttttttacag gtgaagtaat tgatatagat
     3121 gcagaaactg gtggatataa tttacaaata gcattttcaa ctggatatct tgcgggtata
     3181 agtgtataaa tataattttt taataattaa atatgaataa atagaggtgt atatatgggt
     3241 aatttagtta tagctgtaga tggtccagca ggagctggaa aaagtacaat agccaagata
     3301 gtagcaaaaa agctaaatat aaattatata gatacaggtg ctatgtacag agcagttact
     3361 tataagtgtt taaaaagtgg tattgatgtc aataatgaaa aagaagttat tcaaatagct
     3421 gaaaattcgg atatagattt taaagataac aatatatatt tggacaaaga agttataaat
     3481 gaagaaataa gaacaataga agtaagcaat aatgtttcta atgtagcaaa aataaaagaa
     3541 gtaagacagt tgatggttga agttcaacga aaaataggaa tgaaaaattc agtaatacta
     3601 gatggtagag atataggttc atatgttttc ccagatgcag attacaaatt ctttttagta
     3661 gctactccag aagaaagagg aaatagacgc tataaagaac tttgtaataa aggatataat
     3721 actactttag aagaagtaat tgaggatata ataagacgag atgaaattga ttcaaataga
     3781 gaatttgcac cattggtaaa agctaatgat gcactagaaa tagatactac aggaaaaact
     3841 atagaagaag ttgtagaaga agttgtatct aaaataaatc tttagttttt tatgcatcat
     3901 aatgaaaata aatgtagtgt tgaagggaga taaacgtgaa tttttataga tttgtaataa
     3961 atatttttaa gggtttttct aaaatatttt ttaaatatga agttataggt gcagagaata
     4021 ttccagatag aggaaatata gtaatagcat caaatcataa atcgaatctt gaccctatat
     4081 tcttggctgc tgccatagaa aatagagaaa tagctgcaat tgcaaagaaa gaattgttta
     4141 aagtaaaacc attgggattt atattaaaaa aattgcatgt tatgcctata aatagagaaa
     4201 aaccagatgt atctacaata aaaactattt taaggtcagt tagagacggt tatgtattag
     4261 gaatatttcc agagggtact agaataaaag gagattcttt tggtaaggct aaggcaggtc
     4321 tttctgtatt tacaataaaa agtaaatcta aagttgttcc agtatcaata atatctaaat
     4381 ataaactttt tagtaaagta attgtatata ttggagaacc aatatcattt gaagaacatt
     4441 ttaaggaaaa attgagtaat gatgaccatg aaaggatatc acaagagatt ttagaagtga
     4501 taaaacaaaa ttactttaaa tattcaaaat aagggggtaa agttatgaac ataaaaatag
     4561 caaaaaatgc tggcttttgt tttggagtaa aaagagcaat gaaaatggca tgggatgaag
     4621 ttgaaaaaaa tgattctggc atatatgctt taggtcctct tattcataac aagcaagcag
     4681 tagcaaaata tgaagaaaaa ggtcttaaga ctgtgaatga aattgataca ataccaaatc
     4741 atgaaaatat gataataagg tctcatggag ttcctgaaaa tatatataag gaagccaaag
     4801 ataaaaaatt aaaaattgtg gatactacat gtccatttgt aaagaaaata catacagtag
     4861 taagtgaata tcataataaa ggctatgaaa taatagttat tggagatatg aagcatccag
     4921 aagttatagg tataaatgga tggtgtgaaa attcagctat aataataaag accttagaac
     4981 aaatggaaaa tatggaattt gataactcca aaagatattg tcttgttgca cagactacaa
     5041 taaatccaga gttgtatata agtatagtta ataaactatc agataaatta gaagaaatag
     5101 tatttaatga tacaatttgt tcagctacaa aaacaagaca agaatcagct aaagagttag
     5161 ctaaagaagt tgattgtatg atagttatag gaggtaaaca cagttcaaat actcaaaagt
     5221 tagtaaaggt ttgtgaagac ttagtaccaa cttttgcaat agagactaaa gatgaattgg
     5281 atgtaaatac gcttaaaaaa tataaaaatt tgggtattac agcaggggca tctacaccta
     5341 attggataat agaagaagtt gtaacattcc ttgaaaattt ataatttgat aggtaataaa
     5401 aataggtgga cattgttata atttatcata atatccacct ttgatttcat attacatgtg
     5461 gtaaatagat aacctaatat caaaaagtgt gtatcttaag atgaaaaact aagagtataa
     5521 gatgcgcact ttttaatatt agaaattcaa aagaaatatt gatattgatt atcaatagaa
     5581 aatagaatat aatataattg ttgcaaaatt agtctaggag gtaaattaat ggaaatgttg
     5641 atatccgctt ctgaagaggc gtttttacat gtaggttcta tgattggatt ttttattttg
     5701 ttatttggat atattaatta taaaactagt ggaaatttta ctaatatcat atcaaaaaac
     5761 agaaaatttc aacccttaat aggtgcttta attggagcta taccaggttg tggcggaagt
     5821 ttggcaataa tgccattgta tataaatgga aaattaagct ttggagcaat aattgcaagt
     5881 ttaatagcta gtatgggaga tgcagcattt gtacttattt catcaaatat taaaatgtat
     5941 ttttttgtca ctatagttag tacaattaca ggaataataa ctggacaatt agtggattac
     6001 tttaaactag aagaaaaatt agggttaaaa aaccgtagaa aatcagataa atatgatata
     6061 agtaaaaata accctaaaga aaataaagaa caacataatc atgatgaaat aattttagac
     6121 actctagcta aatctcatgg aaatacaaat agacttgcat ttataataac acatggaaag
     6181 ggatataaaa tttatatagg aattatagta atcggtttta tatttatgtc acttgctcac
     6241 tctggactta atcttcctat aattgagaag ttacattcat tggaagaagt aatagcagtg
     6301 attggaatat tattttcaat aatttatatg tggtgtttta aaaaggtatt taaaaattct
     6361 aatcaaaaag aggaagaaaa taaaaagatt tctttgcgag aaatgcttat ccattctgtt
     6421 ggagaaatat catttgtaat tacatggatt tttattgcat atcttattta cgatttgata
     6481 atattaattt taggtggaga tgaatactta gttaaattag tattatcaac aggtgtaata
     6541 agtgtattta taggtgcagg tcttggactt attccaggtt gtgggataca aattgtgctt
     6601 atgtcatttt atttgaaggg aactatacca cttggtgcag tgatagccaa ctctatttct
     6661 caagatggag atgcactttt cccactttta gcaatggata aaaaatcttc tttatgggct
     6721 atgattatta ctactatacc agcaatactt gtaggtatga tagtttatgc atttttaggt
     6781 taaatataat tatgaataaa gaagtattaa aaaaataata aagcacataa atttatttat
     6841 aagaatagtg aagattaaat ataaaaataa aaaattcaat atgaattaaa ttattgctta
     6901 aatattaatg agaacatggg agataatatt attcctcatg ttctctctat ttaattaaag
     6961 gaattatgga acaaatttca agtgatactt tctatcaaaa ctcatatata atatatatta
     7021 ataaattaaa ctataatacg taatacagtc agtatattga tataaaaaac ttaggaggag
     7081 ttgtaaaaat gggtaattta aaaagacagt gtgatgtttc aagtggaaga gaaaaagctg
     7141 acattgtact aaaaaatggg acaatcataa atgtatttac agaagagtta ataacaggag
     7201 atgtagcaat agtaggagac actattgttg gaattggcga ttacaagggc aatgtagaaa
     7261 ttgattgtag taacaaatat atatcacctg gctttattga tgcacatatg catattgaat
     7321 ctacaatggt aatgccaatt gaattatcga aaaaattatt aaaatcaggt acgacaacta
     7381 tcatagccga cccacatgag ttggtcaatg taaaaggagt tagtgcaata gattttttat
     7441 tagaatcgac aaaagatata ccacttaatg tatatattat ggtgccttca tccgtacctg
     7501 caacaagttt tgaaactaat ggagttggta aatttagtgc aaaagacatg gagagttatg
     7561 taaataatcc tagaatttta ggtttaggag aggtaatgtg ttttaatgat gttataaatt
     7621 ctgaaaatga aatcttggat aaactagagc tttttaaaaa taaagttgta gatggacatg
     7681 cacctaatat aaatggtaaa tcacttcaga catatgtatg tgcaggaata gaaaatgacc
     7741 atgaatgtat aacttttgat gaagtatatg aaaaattgag agcaggatta aaaattttaa
     7801 taagagaagg aagcgcagca aaaaatttaa agtctatagt aagtggtatg ctaaagcata
     7861 acttgccaat tgaagaattt atgttttgca cagatgataa gcacttagat gatatagaaa
     7921 aacaaggtca cataagatgg aatataaaat gtgcgattga tttaggtatg gaacctgtta
     7981 gggctataaa agttgcaact tataattctg caaaagcata tgggttaagg aaaattggag
     8041 caataggtgc gggttataag gcagatattg ttgtattgaa tgatttagac aaaatggaag
     8101 tggatagtgt atataaagat ggtaatttgg taaacgaaga gatgttttct aattacaatt
     8161 atgagattaa agataaagaa ttgcttaata cagtcaagtt taaatatatt aataaagaaa
     8221 aaatacagtt aaaagtaagt gaaaaaaatt atgtaatgga gattgtacct tatcaaattt
     8281 tgacaaataa ggtatatgaa tctttaccat gtgcagatgg atattttgtt ccaaataaag
     8341 agtattcaaa actttgtgtt gttgagagac atagaatgac tggaaatgta gcaattgctc
     8401 cactaaaagg atttggcata aaaaatggag caattgctac tactgtggcc catgattctc
     8461 ataatattat agttgcaggg gataatgatg atgatattct agtagctata aattacttaa
     8521 aggaaataca aggtggttat gtaattgtat caaatggaaa agttcttgca cacctaagtc
     8581 ttcaagtagc tggattaatt agtactttta cagctgaaga agtacaagaa attactgata
     8641 atatgttgga gatagcaaga aaaatggaag ttccagagta tgtagaccct tttattacac
     8701 tttcttttat ggcacttcca gttgttccac aaataagact tacagattta ggtctatttg
     8761 atgttgagga atttaaattt atatagatag tataaaagta ataataaatg aggctttctc
     8821 aaaatagaga taagtctctt tttattgttg aaatgatgaa aatatatttg atttcataca
     8881 aaaaagagca tctcatgaac taaaaatttt atttttagat atccttattt taattaatct
     8941 atcatttaac attgttttaa gcatagatat cttaataaaa ctattttcag tctattttaa
     9001 catataaata catgaaaatt atatatttat gaaactttat acataaaaaa taaaatattt
     9061 tatttatata tagatttata gggtaataat ataagcatag tataaaatta ttaataaaaa
     9121 caaaaggaga gatatttatg ttgagtatag gaacaaaagc accagaattt acactagaag
     9181 ataaagatgg aaataaggta agtatgtcag attttaaagg caaaaaagta gtagtatatt
     9241 tttatcctaa agataataca ccaggatgta cacgtcaagc ttgtgctttt agaaatgcat
     9301 atgatggatt taaaaaggaa gatatacaag ttattgggat aagtaaagat agtataaaat
     9361 cacatcaaaa atttgcagaa aagcatgaac ttccttttat tttactttct gaccctgact
     9421 tagttgctat aaaagctttt gatgtatgga aagagaaaaa aatgtatgga aaaactgcat
     9481 tgggagttgt acgtgcgaca tatattatag atgaaaatgg aattattgaa aaagtctttg
     9541 aaaaagcaaa accagacaca aatgcacaag agattcttga atatttggaa aaacaggagt
     9601 aataagaatt tatgattata atgttatcac cagctaaaaa tatgaagaat atagaagtat
     9661 ttgatagaga tttgagtttg ccttgcttta tagataacac aaaagaaata gtggaaaata
     9721 taaagacatt tggtatagaa gattttaaaa ataaaatgaa aattaatgaa aaattagctg
     9781 tattaaataa aaatagattt gaaagcatta aatttgatag attaggaaac cctgcaatct
     9841 taacttatga tggaatacaa tataaaaata tagaagcaga aaattttaca aggaaagatg
     9901 aagagtttgc aaatagctgt attcgaatca taagtggatt gtatggtgtt gtaaaaccat
     9961 atgatagtat atatgaatat agattagaaa tgcagacaaa attacaagta ggtgagttta
    10021 agaatttata cgaatattgg ggaaatcgta tatataaaga actaatcaaa gaaaaaacag
    10081 ctatcgttaa tctttcatca aatgaataca gcaaatccat agaaaaattt attaaagata
    10141 gtgatacata tattacatgt acttttaaag taaataaaaa tggcatattg aaagtggaat
    10201 ctacacaagc aaagaaagct agaggtatga tgacaaaata cattgtaaaa aataggataa
    10261 gagatattga agaactgaaa aagtttgatt tagaaggtta taagtataaa gaaaacttat
    10321 ctaacaatag tgaatacata tttgtaaaag agtagaagtt ttgttaaata ttaaatggca
    10381 ttgttaaatt taggtaaaat atacttagtg tgtattgaat tgaacttgat tttaaaatat
    10441 aattattctt aaattaaaaa aagaaaggag tggtcttcca aaatggaaaa tcacaaacag
    10501 atgccttggc attcaagagc aacgcatgaa attttagaaa gtctagattc atcagaggag
    10561 gggctcaccg ataccgaggc ggaaaaacgg cttaaagaga atggcttaaa tgaacttaga
    10621 aaaaaaccac ctagaacaac tttacaaatg ctttggagtc aaattacaga tgctatggtt
    10681 atgatactaa taggagcagc aatattatct ttgatatttg gcgaatttac agaagctttt
    10741 gtaatactaa taattgtaac agtaaatgca gttattggaa ttgttcaaga gaaaaaagca
    10801 gaatcatcat tagaagcatt aaaaaatatg aattcaccta cagctcgtgt tatgcgtgat
    10861 ggtgaagaaa atgttattcc agcaagtaat cttgtagtag gagatattgt ttttttagaa
    10921 gatggagcta tggttccagc agaccttcgt ttaatagaaa catcaagttt aaaaattcaa
    10981 gaggcttctt taacaggaga atctgttcca tcagaaaaag atgcagatac aatcttacct
    11041 aaagaatgtg tattaggaga ccgtagcaat atggcgtata catcttcaat agtcacatat
    11101 ggtagaggtg taggtgttgt agtagcaact ggtatggata cagaagtggg taacatagca
    11161 catcttttag attcacaaga tgattttgat actcctataa aacgtaaact taatactgtt
    11221 ggaaagacat taagtgtcat aggtattatt gtatgcgttg ttatatttgc aataggtgca
    11281 ttttatcaga gacctctctt gccaatgttt atgattgcaa tttcccttgc catatcaatt
    11341 attccagagg gattacctgc aacagctact attgtaatgg ctttaggcgt acagcgtatg
    11401 gctaaaagaa atgctttaat tagaaaatta cctgctgttg aaacattagg aggagctaca
    11461 gtaatatgtt gtgataaaac tggtacatta accttaaata aaatgactgt tacacatatt
    11521 gctgtcaatg gagattttga atctggaaaa gtgacatcaa tagatactgc atctgaaaaa
    11581 catccattag tgtataaaga gattgtttat gctggtgcac tttgtaatga tgcatgtatt
    11641 aatccagata aaacagatga aatattaggt gacccaacag agggcgcatt aatttttatg
    11701 gccaaaaaat ttggaataga tcaagaagct cttgaagaag aatatccacg tgtatttgaa
    11761 cagccttttg attcagatag aaaatgtatg acaactgttc ataatataga tgaaaagatt
    11821 attgcttata ctaaaggagc agtagacgaa attcttgacc tatgtactaa aatattaact
    11881 tcaaaaggtg aaagaaacat tactgaagtg gataaaaaga atatacacga attatgtctt
    11941 aacatgtcta aagatgcatt gcgtgtactt ggttttgcta agcgtgagat ttcatctata
    12001 ccaaaagaag atagtgaaaa tatagaatat gatttaacat ttataggtat ggttggtatg
    12061 attgacccac caagaactga ggtaattgat gcagtaagta cttgtaaaga agcaggtata
    12121 agaaccataa tgataacagg tgaccataaa gttactgcca caacaatcgc tcatgagtta
    12181 ggaatatgga gtgaagaaaa tactgtgata tctggtgatg aacttgataa tttgagtgat
    12241 gatgaactag atgaagctgt taaaaatact acagtatttg ctcgtgtatc cccatttgat
    12301 aaacttagaa ttatacaatc tctaaaaaga attggagaag taccagcaat gactggggat
    12361 ggtgtaaatg actctcctgc cttaaagtct gctgatattg gtatagccat gggtataagt
    12421 ggtacagatg ttgcaaaaga ttcttctgac atgattttaa tggacgatag ttttacaaca
    12481 attgcttatg caataaaaga aggtagacgt gtatatagaa acatacaaaa agttatacaa
    12541 tttttgcttg ttggtaatat agcagagata cttacgttgt ttgtagcaat attattaaat
    12601 tgggatactc cgcttcttgc tgttcatatt ctatgggtaa accttgcaac tgctacgctt
    12661 ccagcccttg ctcttggagt tgacccacca agcagaaata taatgaagca ccagccagtg
    12721 aaatcaacca ctttgtttga aaaaaatctt atacaaagag ttgttaccca aggtatattt
    12781 gtggcaataa tgactatttt agcatataaa attggtctta atatagaaaa tcattctgta
    12841 ggtcaaacaa tggcattttg tgtattagca ttttcacaga tgttacgagc atttagtcag
    12901 cgttcaaata cagattcaat gtttaataga aataatggta aaaatccatt tcttttaatc
    12961 tcatttttaa cttctgcatt tttaatagca gtaatactat ttgtacctgt ttttagaaat
    13021 gcttttaact taacagtttt aaataactta gagtggcttg taacgattgt tttagccata
    13081 atgtctgtaa ttcaagtaga ggttgggaaa attattaaaa gaaaaaaatt aaaaaaatag
    13141 ttgacaaaat taggaaaaat atataagata taaaacatag aaaaattaaa taaatcttat
    13201 ccagagaggt ggagggactg gccctatgaa acccggcaac cagtatattt atatacattg
    13261 gtgctaaatc ctgcggcgaa agctgagaga tgagtataat taagcttata cagagcctga
    13321 gttatatact caggctttat ttattttaac tctcatctgg taaatagttt aatttttttt
    13381 actaaaatct aagggggata caagaatgta taataaagaa acaatatgtg tgcaaggaaa
    13441 ttataaacca ggtaatggag aaccaagagt actaccttta tatcaaagta caacttttaa
    13501 atatagcagt atagaccaac ttgctgaatt atttgattta aaagttgatg gacatatata
    13561 ttcaagaata agcaatccta ctattcaagc ttttgaagaa aaaataagtt tactagaggg
    13621 tggagtatct tctgtagctg tatcatcagg gcaatctgca aatatgttgg cagttttaaa
    13681 tatatgtaaa tcaggagata gtatactttg ttcttcaaaa gtatatggag gaacattcaa
    13741 tttactagga cctagtctta aaaaatttgg tatagattta atatcgtttg acttagattc
    13801 aagtgaagat gagatagtag aacttgcaaa ggaaaatact aaggttgtgt ttgcagaaac
    13861 acttgcaaat ccaactcttg aagtcataga ttttgaaaaa atagcaaatg tagctaagag
    13921 aattaatgtt ccatttattg ttgataattc attagcatct ccagtgcttt gtaacccttt
    13981 aaagtatgga gcaaatatag ttactcattc taccacaaaa tatttagatg ggcatgcttc
    14041 aagtgttgga ggaattatag tggatggtgg aaactttaac tgggataatg gaaaatttcc
    14101 agaattagtt gagccagacc caacatatca tggtataagc tatactcaaa aatttggaaa
    14161 tgccgcatat gcaactaaag caagagttca gttgcttaga gactatggaa attgtttaag
    14221 cccattcaat gcgtatctta ctaatttaaa tgttgaaaca ctacatctta gaatggagag
    14281 acatagtgaa aatgcactta aaatagctag atttttagaa aaacatgaaa atgtagattg
    14341 gattaattac ccaggacttg aagataacaa gtattatgag aatgccaaaa agtatttatc
    14401 aagaggatgt agtggtgttt tatcatttgg agtaagaggt gggttagaaa atgccaaaaa
    14461 atttgtggaa aaattacaga tagcatcttt ggttacacat gtttcagatg taagaacttg
    14521 tgttatacat ccagcttcaa ctactcatag acaattaaca gaagaacaat taattgcatc
    14581 tggagtattg ccttcactaa taagattatc tgttggaata gaaaatgtag aggatttaat
    14641 agctgattta aatcaagctt taaatttcta atattctaag agaaagagaa gtgaaaagat
    14701 atggctttaa tactaccaaa gggattacct gttattaata aattattaga tgaaggaata
    14761 gatgtaattt ataaagaaga ttttaaaaag gaattaaagt atgaagaaaa catagacact
    14821 aagatagcta tactaaatct aatgcctata aagatagata cagaattaga tttactaaga
    14881 aggatagata aaacaggatt caacgtgtct gtggaattta ttaaaatttc aacaagagaa
    14941 agtaaaagaa gttgtaatga atatgttaaa gaattttata aaacatttga tgaagccaaa
    15001 ggagagtatt ttgatggctt tataataaca ggagctccag ttgaacaaat ggagtttgaa
    15061 gaagttgatt attggaatga actagaagaa attatggatt attctaagag aaaaactaaa
    15121 tctacattat atatatgttg ggcagctcaa gcaagtcttt acaaatacta caatgtaaaa
    15181 aaacttccac taagtcaaaa atgttttgga gtatttaagc ataaggtaga taaagatagt
    15241 aaaatagtag atggatttga aaatgaattt tttgctccac attcaagaca tactactgta
    15301 aatattgaag ctttgaaaga gaataaagag ttgagcattg tgagtcattc taaagaagct
    15361 ggtccctata taattacaaa ttcaagagat gtgttcgtaa tgggtcatag cgagtatgac
    15421 aaatacactc ttgataaaga atataagagg gatataaata aaggagataa aatatctata
    15481 cctcaaaatt actatattaa tgatgaccct tcagaagagc caactgtaaa atggaaaaaa
    15541 cattcagaat tgttgtttag aaattggata aaaaactatt tgatacaata aattttaaga
    15601 gtatataaat gttaactaaa aaaatataga aatttatagg tataaagtta atcttaatga
    15661 tactttatac cttatttttt taaaatttga ccttataata gtagttttat attttaagaa
    15721 aatcacttta ggtgtatgta gatagaggtg gctttaattt tatatatggt gcgataatgg
    15781 gagactaaac ctttatagta tcaataaatt tgtattttaa cttttaaaag agattaaaaa
    15841 gggagaaatc agtgtaaaat atatatatag attttttatt aaattttatt aaaaatatcc
    15901 tgtataaaat taaatatcaa taagataaca aaatttcaat tgaagttaca atattgtaat
    15961 tgacaataaa tacttaatac tataatattt aatacattaa acattatagt gttaagtatt
    16021 tatttacagt atgcacttca gcctaaattt gaaataaagt attttcgtag ggagcgtttg
    16081 tatggatgag atgagtttta agaaagagct actagagttg actagagata taaatatgaa
    16141 atttacaact ttattaagtg atttttatca gccacttggt attacagcag tgcaagcttt
    16201 gattttatct gagttatgtg aacatggaga gaaaaaaata agcgatttag ggaagaactt
    16261 aaacatgaca aatagtaatg tatcagtaat ctgtcaaagg cttgaaaaaa atggcttttt
    16321 aaatcgcata agagatatag aagaccaacg aattgtaaaa gtaaaagtta caaataaatc
    16381 attggatata caagaacata tttcaagtag tatttttgat agttattttg aaaatatgac
    16441 cagtgaaaaa ttgcaagata tggaagatat aatagaaggt ttagagaaat taaataaact
    16501 tttaacttac attgattgca aataacataa aaataattta aaggagaata aaattatgga
    16561 tgaacataaa ccccaaaaaa ggtcagcact ctattattat acagttataa taatagtagt
    16621 aatgttttta aatgctttaa tatttccaag tttaatggat aaaaaaatgg ttgagattga
    16681 ctatggaaag tttctcacaa tgttggatac aggaaaggtt aaatctgttg agatagaaaa
    16741 taatagaata gcaataaatc catctagtag caaggataag aatatataca taactggtag
    16801 aatggatgac ccagaattgg tagatagact aaaaaatgca aaagtagaat ttactaaggt
    16861 tattcctaag gaaaattcac ctcttttaag tattttactt acatggataa tacctatagg
    16921 tattcttatg ctatttggta acttaatgat gaagtctatg caaaagcgaa tgggtggtaa
    16981 tgctatgcaa tttggaaaaa gcaacgccaa aatgtatgta tctgctcaaa gtggaaaaag
    17041 atttaatgat gtagctggtc aagatgaggc aaaagaagct ttaactgaaa tagtagattt
    17101 cttacacaat ccagaaaagt ataaaaagat aggagcacaa atgcctaaag gagcactttt
    17161 agtaggacct ccaggtacag gaaaaacact ccttgcaaaa gctgtagcag gtgaagcaaa
    17221 tgtaccattt ttctcaatat ctggttctga gtttgttgag atgtttgtag gaatgggagc
    17281 ttctaggatt cgtgatttat ttaaacaagc aaaagaaaaa gctccatgta tagtgtttat
    17341 agatgagatt gatactattg gtaaaaagcg tgataatgga agtggattag gtggaaatga
    17401 tgaacgtgaa caaactttaa atcagttgtt aagtgagatg gatggttttg atggtggaat
    17461 tggagtagta atacttgctg ctacaaatag acctgacagt cttgacaaag cattacttcg
    17521 tccaggaaga tttgatagac gtataccagt tgaacttcca gaccttggag gacgtgaagc
    17581 tatattaaag gtacatgctc aaaatgtaaa tgtaagctca gatatagatt ataatgcaat
    17641 tgcaaggtct acatcaggag catcaggtgc agaacttgca aatattgtaa acgaagcagc
    17701 acttttagca gttaagtctg gcagagatat agtagaacaa caggattttg atgaatctgt
    17761 tgaaactgta attgctgggt atcaacgtaa aggagctgta atttcagata aggaaaagaa
    17821 aattatagca tatcatgaaa taggtcatgc acttgttgct gctatgcaaa aacattctgc
    17881 acctgtccat aagattacta taatacctag aacttcagga gcattgggat atactatgca
    17941 agttgctgaa gatgagagtg tacttatgtc taaagaagaa gcaattgata aaataactac
    18001 ttttacaggt ggtcgtgctg ctgaagaggt tatctttaac acttgtacat caggagcatc
    18061 aaatgatata gaacaagcta ctaaaattgc aagagctatg gttactcgcc ttggtatgag
    18121 tgaagagttt gatatggtcg ctcttgaaac tgtaagcaat caatatttag gaggagatac
    18181 ttctcttgct tgttcttccg acactgctgc taaaatagat gaagaggtat ttaaaatagt
    18241 aaaggcttgt cacaaaaatg caattgaaat cttagaaaat aatattgata aattgcatga
    18301 acttgctaat tatttattag aaaaagaaac tattacaggt gatgagttta tggaaatact
    18361 taacttaaac taaaatgatt atacacaaga taaaaatgcc tattgttagg catttttatt
    18421 ttacaactaa attttttaaa tttatattta aatctttaca taatcttaat cattaaaaat
    18481 acatcttaac tacaatttta tatcggaatt gatattataa tagtaatgaa tggtgtaagg
    18541 aggtttttta atggatagac ctaatcctga tattctatta gaaaaaatta aaaatgaaga
    18601 agaaaaacta agtagaggtc aattaaaaat attctttggt tatgcagctg gagtaggaaa
    18661 aacctactct atgttggaat ctgcacaaaa tttaaaaaaa gtgggtgtag atgtagtagt
    18721 tggatatatt gaaccacaca ctagaccaga aacattggct ttacttgatg gcttggaaat
    18781 tcttcctgta aaggagatag aatataaatc tataaaacta aaagaatttg atttagatgc
    18841 tgctttagca agaaaaccag aagttatatt agtagatgaa tttgcccatt ctaatgttgc
    18901 tgggttaagg catacaaaaa gatggcaaga tatagaagaa ttgctgttag caggcataaa
    18961 tgtctacact actgtaaatg tacaacattt agaaagtcta aatgacattg ttgagataat
    19021 tacaaacgta tcagttaaag agactatacc agataagttt ttggatacaa atacacagtt
    19081 agaacttata gatgttgaac ctgatgtact tcttgaaagg ttcaatgaag gtaagatata
    19141 taagaaagaa caagctacta gagcaaaaaa taattttttt ataaaagata acctggttgc
    19201 acttagagaa attgcactta gaaaaacagc agagagagtt aataaagaag ttcaaatgac
    19261 cagactatca aagggtgatg taactgtaat acctacatca gatacacttc ttgcatgtat
    19321 aagtccatct ccatcttcag caaaagttat tagaactgca tccagaatat cagacagtac
    19381 atttgcaaaa tggatagctt tatatgttga aactccaaac acagcaagac ttccatttga
    19441 tgaacaaaaa caactacaaa ataacctaaa attagctaag aaattaggtg gagaaataat
    19501 tgttttacat ggtgaaaata taatagagca aatacttaga attgcaaagc tgagaaatgt
    19561 aacaaaaatt gtaataggta gaaatcattc aagtaataaa agatttagta aaagatttaa
    19621 aaaagatata gttgacaaat taattgatga agttgattat atagatatac atataattcc
    19681 atataaattt gcctcagatg ttaaatacaa acctaaaaag gataaatcat caataaaatc
    19741 taaatttaaa attagcaaag ttgattttat aaaacttata tttattactt tgatgataag
    19801 tattttagca tatgcagtac aaagcatggg atttataaga gaaaatatat tgttaatata
    19861 tatgttgggt gtagttttag tttctatgtg gactaaaggg tatagtacag gtataataag
    19921 ttctgtattt aatatagttc ttttaaatta tttttttaca gcaccattat atacattatc
    19981 tatagcagat tcaaactata tagtaacact ggttgtattc tcaatagtag gtataataac
    20041 tagcactctt acgtctaaga tacagcatga agcagaaact gctgctaaaa gagaagaaaa
    20101 tacaaaaatg atatatcaaa taattaaggg atttttaaga ttatcaaata aagatgatat
    20161 agtaaacaaa ggtatagaac ttttgtctct tagcttaagt agagatgtaa tttgttattt
    20221 aaatgtagat aagcataata aatcaaagct ttacaaaaaa aatactaata ataaggataa
    20281 aaatgatttg gatagtgaag atgaaaaagc tgttgcaagt tgggttttat ccaattcaac
    20341 agtagcagga aatgacacgg atacacttcc tggttcaaag ggatactata taccaattgt
    20401 aggaatgaat ttaactttag gagtagtggg aatatcatgt attgattcaa aattggatac
    20461 agaagatata agcttaattg aaacaataat tgctcaaatg gcaatagcgc ttgatagaga
    20521 aatcttgtca gaagctaaag aaaataccaa tcttgagatt gaaagggaaa gattaagaag
    20581 taatctttta agagcagttt cgcatgacct tagaactcca ctagcaggaa tatctggtgc
    20641 agtaagtaca attataaaaa acaagggtac tataggtcaa gatataatag atgaattact
    20701 tagtggtgta tatgaagata ctcagtggtt aataagactt gttgaaaatt tacttagtat
    20761 gaccaagata gatgaaggga aattggaagt taaaaaacat tctgaactgg ttgaggaaat
    20821 tatatcagaa gcgttacaaa aaataaaaaa aagaattgaa aatgcactta tagatattaa
    20881 tataccagaa cagatattat ttgttcctat ggatgcaaaa ttaatagaac aagttttaat
    20941 taatttaata gataattctt tgaaatattc aaaggaagat tgtaagatag agataaatgt
    21001 atatgagaaa gatgattatg tttggtttga agtatctgat aatggtcctg gtatatcaaa
    21061 ggaacttaaa aagcatatct ttgacagatt ttttactgga gaagaaggag ctaaagattc
    21121 cagaaagggt gttggacttg gattatcaat ttgtaaatct ataattcaag ctcataaagg
    21181 tgaaattatg gtagaaaaca ataaagataa gggttcaact tttaagttta gtttgcctaa
    21241 ggaaaatgaa tagttttaaa ttttaaaatt agttttggag gaagaaatga gtaaaaaact
    21301 tatattgtta gtagaggatg ataagacaat aagaaaattt atatctactg cacttttaac
    21361 acaggattat gatgtcaagg aggctataac tggaaaagaa ggtatatcta tagctgtctc
    21421 atattctcca gatgttgttc ttttagattt aggcttagaa gatatggatg gaatagaggt
    21481 aataaaagct atcagacaat tttcaaatat accaataatt gtagtttcag ctagagagca
    21541 agatagagac aaggtagaag tatttgatgc aggggcagat gattacttaa caaaaccatt
    21601 ctccatagta gagttattag caagagtaag agtagcattt agacattcac aagtagaagc
    21661 tcaacaaaaa gatgatgtta aatctacgtt tgaagtagat aaattattga ttgattttga
    21721 taaaagaaaa gttattgttg atgatgttga agtccatttg acacctattg aatataatat
    21781 tctttcatta cttgcaaagt atcatggaaa agtgcttact cataatttta taataaaaga
    21841 aatatggggt agtgttatag ggaatgagac taagtcttta agggtcttta tggcaacgtt
    21901 aagacgaaaa atagaaaaac aacctgcaaa cccaagatat ataattacag aagttggtgt
    21961 aggatacaga ttaaatgatg aatagttgta atatattaat tattagatta tgtgcttatt
    22021 aatatatatt aaaattatat agtttagtta aaataagaat gaagtgtatg tgcttgttgt
    22081 cagtttagca catgcatttt attttttagc ttttttagta tcaataattt tttagtatca
    22141 ataatatgaa atatgtttta aaataagtat atagtgta
//
LOCUS       DAEHWM010000070        22134 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.071, whole genome shotgun sequence.
ACCESSION   DAEHWM010000070 DAEHWM010000000
VERSION     DAEHWM010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22134)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22134)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22134
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.071"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            451..1521
                     /locus_tag="KNP36_002601"
     CDS             451..1521
                     /locus_tag="KNP36_002601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874462.1"
                     /translation="MADIRLENVTKSYNKKNTVIENLNLTIEDGSFTVLVGPSGCGKS
                     TTLRMIAGLEDITSGRLKIEENDVTKTDASKRDIAMVFQNYALYPHMTVRENIEFGLK
                     NKKVEKEKREKLITEVIDVVGLREYLNVKPGNLSGGQRQRVALARAMVKNPKVFLMDE
                     PLSNLDAKLRNQMRTELIQLHQKLKSTFVYVTHDQVEAMSMADKIVIMNKGKIMQIGS
                     PKKIYQNPKNLFVAQFIGSPCMNILDIKNDIKFGFRPEKATLESINIDGKNDDVFSLF
                     GKVVTKEVLGNETIYCLSVLNREIRVKTENDIFDIGRTLRISVLEKDLYYFDKNGERI
                     EDVKVCKSMYSKIKGDIYEKAI"
     gene            1505..2374
                     /locus_tag="KNP36_002602"
     CDS             1505..2374
                     /locus_tag="KNP36_002602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HBF0874463.1"
                     /translation="MKKQFNKAYLYITPAIIGTLLFIVYPIIKTISLSFKSGSLLSST
                     FENVGLNNYTELLKNPEFIQTITNTAIYTFFMVTISISLAIVLAVWLNKNSIIHNLTQ
                     SIIFTPHVISLVSVAVLWLWIMEPQYGFLNWILSTLHLPTSKWLSSESSALMSLILIG
                     IWKTLGYNILIVLSGLKSIPNYIYEASKLDNANKITNFFKVTLPLLSPTIFFLMITTT
                     TASFQVFDEISIMTQGGPVGSTNMLSYYIYESGFIYYDIGQASAASMFLLAIVMIATY
                     ANFRLLSKKVHYQ"
     gene            2418..3278
                     /locus_tag="KNP36_002603"
     CDS             2418..3278
                     /locus_tag="KNP36_002603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HBF0874464.1"
                     /translation="MDIIQPIKKDKVDIKKIASKSIEILILLLLSAIFIFPFIWMLST
                     SFKNPQEMMQLPPTIIPNDIVLENYSTAWHSGPFFRYLLNSVFVTGSVLIVQFLVMVP
                     AAYAFSKIKFKGEKMLFGLLLVGLMIPPQVTFLPVYMMMSKFGFINTYVPLIIPFMTS
                     SFGIFLLRQNFMQISDEIIEAAKLDNASDLKIMFRIMVPMAKPAVITFILFNFIYHWN
                     NYFWPLVMTNTDAIRTLPIGVALLKSSEGITAWNVIMAGNIILILPIILVYIFANKKV
                     KEAFMYSGIK"
     gene            3309..4613
                     /locus_tag="KNP36_002604"
     CDS             3309..4613
                     /locus_tag="KNP36_002604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HBF0874465.1"
                     /translation="MKLKRKLATGLAITLLLCSLVGCSNSNDANASKGEKTDSNITKI
                     DFWAPLGGTNGETAQKMVDQFNSEHKDVQVNMLKQKDYYENATKLQAALTSKDQPDVT
                     LLEITQTGTFASAGALVDMSKYFDKTYQERFFSGLLTNSYYEDKFVGMPFNRSTPILY
                     INKDMATKAGLDPSGPKSWEELKDYASKMTNKSEDTYGFETPIDIWFYEAMVMQSGGE
                     ITNGKKVAFNNEAGQAPVKFWQDMMKAGIMKMPPGEDYNAWDVAKQDFVNGKVGMIFT
                     STADLAGLMQQTEGKFEISTAFLPKNQKYATPTGGANLVMLEGGTDKEKEASAEFIEW
                     MTQTDKIVQFSSSTGYLPTTEDATNSEKLQTLYKEKPQYKVATDQLQYAVALPMLNGY
                     KEATDKLMDEIKKGLTDLNANPKDVVSKGTSAMQAVIDKTNK"
     gene            4676..5938
                     /locus_tag="KNP36_002605"
     CDS             4676..5938
                     /locus_tag="KNP36_002605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline phosphatase family protein"
                     /protein_id="HBF0874466.1"
                     /translation="MTKVIVLSVDSLFEKDLEFVKNLPNFKSILENCSIVKNINCVYP
                     TLTYPCHTSMVTGVYPKKHGIYHNEKFDPNKENKDWYWYSKDIKAKTIIDVAKENNLT
                     TSSVLWPVMGANPNIDYNIAEIWAPSREDDPRETFERSSSKVIMDGIYNRHCHYIDWK
                     LEPNMDLFGVNCSVDIIKEYKPDLMLIHLATLDHTRHNYGLFNDEVDKALKMNDKWLG
                     DIIQATKDAGTYKDTNFIILGDHGHLRVDKVINPNVLLKSNGFIKVENGEVKDFDAYV
                     NSSGISAQIIVNNLDRLTELRELLEEFKEELFIENIFTKEEASNLGLEGDFEMVIEGL
                     EGISFGNDFEGSIIKDSDIKDYKFAVATHGHLPTKGNRPPFIAFGPNIKGGVVIEEGD
                     LRAHAATILKMFNLKLDGVEKEAFDFIM"
     gene            6125..8095
                     /gene="uvrB"
                     /locus_tag="KNP36_002606"
     CDS             6125..8095
                     /gene="uvrB"
                     /locus_tag="KNP36_002606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="HBF0874467.1"
                     /translation="MDFKIKSDFKPTGDQPEAIKSIVDSINRNEKFSTLLGVTGSGKT
                     FTMANIIQQVKKPTLIMAHNKTLAAQLYSEFKEFFPDNAVEYFVSYYDYYQPEAYVAH
                     SDTYIEKDASINDEIDKLRHSATASILERRDTIIISSVSCIYGLGDPKDYKELMLSIR
                     PGMQRDRDDVIKRLIEIQYERNDINFTRGTFRVRGDILEIFPASNDEKAIRIEFFGDE
                     VDRITEIDYVTGKIVGTRNHVVIFPASHYVTTPERIEKAIVEIENELQEQIKFFKEND
                     RLLEAQRIEQRTKYDIEMLKEIGFCQGIENYSRHITGRSEGERPYTLMDFFPDDYLII
                     VDEAHVTIPQVRGMYAGDRSRKTSLIENGFRLPSALDNRPLNFQEFEGNINQMLFVSA
                     TPGPYEIQHSETIAEQIIRPTGLLDPIVEVRPINNQIDDLVGEITKTIEKNERVLITT
                     LTKKMSEDLTNYLKEIGIKVKYLHSDIVTLERTEIIRDLRLGKFDVLVGINLLREGLD
                     IPEVSLIAILDADKEGFLRSETALIQTIGRAARNENGRVIMYADRITDSMQNAIDETK
                     RRRDIQNLYNEEHNIIPKTIQKNIRDSIEATKVAEEEVVYGISDTDDKDEIRANIDKL
                     KSEMMEAAQNLQFERAAELRDKVKQLEEKLEK"
     gene            8114..10939
                     /gene="uvrA"
                     /locus_tag="KNP36_002607"
     CDS             8114..10939
                     /gene="uvrA"
                     /locus_tag="KNP36_002607"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBF0874468.1"
                     /translation="MEDKIIIRGAKEHNLKNIDLELPRDKFIVFTGLSGSGKSSLAFD
                     TIYAEGQRRYVESLSAYARQFLGQMEKPNVEYIEGLSPAISIDQKTTSKNPRSTVGTV
                     TEIYDYLRLLFARVGDVYCPTCGEKISQMTIQEIVDKMLDFPDRTKLQILSPIVRGQK
                     GTHKKVFDNIKKEGFVRVRVNGENYEVSDDIILNKNQKHNIEVVVDRIVIKDGIESRL
                     ADSIETAVKLSDGLVIAQIIDGEEILFSTKFACPEHGIGIEELSPRMFSFNAPFGACD
                     VCNGLGESKEVDPELVVPNKDLSIKQGAVAAWGSTGVNDDTYYSKMIKSLAEHFNVSL
                     TTPFKDLPDDFVEELLYGKDNIIVEFTYESKFGGTRNYKSYFEGVIVNLERRYRETNS
                     DYMRDKIEEYMAERPCPKCKGMRLKKEVLSVLVDGKNIMEVTNLSVNELIDFMENINL
                     TEKQRFIAHEIIKEIKGRAMFLRDVGLDYLNLSRKAGTLSGGEAQRIRLATQIGSALV
                     GVLYVLDEPSIGLHQRDNDRLITTLRHLTDLGNTLIVVEHDEDTMREADYVIDIGPGA
                     GIHGGEIVAQGTLDEIIENENSITGQYLSGKKQILLPETTREGNGSFIEIVKASENNL
                     KNIDVKFPLGKFTCITGVSGSGKSTLINDILYKGVASKVNRLKQRAGKHKEIKGIESI
                     DKVINIDQSPIGRTPRSNPATYTGVFDFIRDIFASTNEAKARGYKKGRFSFNVKGGRC
                     EACKGDGIIKIEMHFLPDVYVPCEICKGERYNRETLQVKYKDKTISDILDMNVEEAVE
                     FFENIPNIKRKLETLMDVGLSYIKLGQPSTQLSGGEAQRIKLAAELSKRPTGKTLYIL
                     DEPTTGLHMADVDKLIQVLQRLADTGNTIIVIEHNLDVIKTCDYVIDLGPEGGDKGGT
                     IVATGTPKEVSKVDGSYTGQFLKKYFS"
     gene            11198..13015
                     /gene="uvrC"
                     /locus_tag="KNP36_002608"
     CDS             11198..13015
                     /gene="uvrC"
                     /locus_tag="KNP36_002608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HBF0874469.1"
                     /translation="MFDIQEHLKKLPSEPGVYLMKDKYDHIIYVGKAISLKNRVRQYF
                     QSSKNHTSKVKSMVKNIYKFEYIITDSELEALILECNLIKRYRPKYNVVLRDDKTYPY
                     IKVTTNEDYPRILKVRRVLKDKAKYFGPYTNITAVNDTLELISSTYPIRSCKIDIDKA
                     IKNKTRPCLNLHINKCLGPCTGNVSKEEYGKMIEEIIMCLSGKEEKLMELLKEKMNES
                     SMNFRFEEAAVYRDKIKSLEEMIQKQKIDATVSDLNQDVVAMARAHNEACVQVFFIRN
                     GKIVGREHFILEGVMDSPRASILSSFVKQFYNEQEYIPKELIIEDEIEDSSILEEWLS
                     SKKGQKVTIRVPQKGEKKSLVEMVRKNAVEYLEKFSDMNKRKYEKSIGALEELKQILN
                     LEKLPIRIEAYDISNIQGVDSIGSMVVYTNAKKDKKEYRRYKIKTVIGPNDYDSMAEI
                     VDRRLKHGNLPDLILLDGGKGQVSAVKKVLELNDVDIPLWGMYKDDKHRTKGLICKEK
                     EIELDKTTNLYRFIASIQEEVHNYAITYHRSLRNKVLTKSILDDIQGIGEKRKKSLLN
                     HFKDVDAIKKATMEELLEVDGMNKSIADNVYNFFRKEEN"
     gene            13015..13944
                     /locus_tag="KNP36_002609"
     CDS             13015..13944
                     /locus_tag="KNP36_002609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HBF0874470.1"
                     /translation="METSNKVSIREIIKELKLKVVYMPDDVDYYVYSQDINRPGLQFA
                     GYFDYFAYERIQIVGKTEYNFFGLMDSHIREEVLDRFFSYEIPALIISRDLEIKPDVI
                     EKAKKYKRILLSTNRNTTRLINRLSNYLDNKLAPHTTIHGVLVDIYGIGVLIKGESSI
                     GKSETALELIQRGNRLVADDAVEIRKLDESMLVGQSPELIRHFLEIRGIGIIDVRSLY
                     GVGAIKNSKMIDLVVHLEAWDETKYYDRLGLDKEYEEILGVNVEKLVVPVKPGRNTAM
                     ILEVAAMNFRQRGMGYDAAQEFTKKLSKLIDTK"
     gene            14156..15952
                     /locus_tag="KNP36_002610"
     CDS             14156..15952
                     /locus_tag="KNP36_002610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannonate oxidoreductase"
                     /protein_id="HBF0874471.1"
                     /translation="MGIEYFSKLLESSTEKELLLSKKSNNISTARLISFLIVIAGLAI
                     GFYNKNIVGIFVGVLSIIIFIALLVIHSKVKEEETYFKSKSEVLNKYIKRFGDGWKEF
                     KIDGKEYLKDENSQAKDLDLFGRASLYQYICVANTSYGKNFLAKYLWNENPDENIILE
                     RQRAIKELLSKDDFSIHIQTLSNIIGKEQKNNSDSSIESFIEYGENKNVYIPKWMHIF
                     TWGLPTATILSFIFCMLGFLPVLPVFLLFIIQLGFSGFGYPRLMQTLAPLFSFSRSIQ
                     VYEKMFEVLEKETFESAYLKELQDKLSKGSGVSRGVKQLNSIGNAVNLRYNQILYIIA
                     CGVLMWNYHCAEALERWKGIYGNQIRDWFESIGEFEALISLTVVSHVKENTCFPVIKY
                     EDTPRLKVEEVYHPLIAEKSVIANSIQLNSQTCIITGSNMSGKTTFLRSIGVNLVLAY
                     AGAPVCAKSFDATCMAIFTSMRIQDDVSQGISTFYAEILRIKSMIQYSLKELPMLVLV
                     DEIFKGTNSADRIIGASEAVKKLSKPWVISMVTTHDFELCDLSGSGDVEVVNYHFSEY
                     YVDDKIHFDYKIKDGRCKTTNAKQLMRMAGIL"
     gene            complement(16092..17873)
                     /locus_tag="KNP36_002611"
     CDS             complement(16092..17873)
                     /locus_tag="KNP36_002611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron hydrogenase small subunit"
                     /protein_id="HBF0874472.1"
                     /translation="MSLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEID
                     KLDTCASCRVCMVETERGLVPACGTVIKEGMKVQTNSAKALNARRTIVELLLSDHPQD
                     CFVCEKNGDCELQTIAADLGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETV
                     CNDIQTVGALSGVNRGFNTLVSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKL
                     WDVLNKKEKTIVVQVAPAVRVAIGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGA
                     DFTIMEEATEFIERIQKGENLPILTSCCPAWVNFLEHNYPDKLNLASSCKSPQGMFGS
                     IAKNYYAPKILGINPEELYVVSVMPCVAKKYEASREELSESGILDVDLSITTRELAKM
                     IKEAAIDLPNLQDQDFDNPLGKSTGAASIFGASGGVLEAALRTSYEKITNKTLDNVNF
                     TNVRGLKGIREASIDVDGTTVNVCIVNTLKNARKIMDKVRSGECKYHIIEVMACPGGC
                     VGGAGQPYHHGNTEIVDRRANALYEIDRNKAIRKSHENPDLQAIYKDFFGEPNSDVAH
                     KYLHTHYFDKSCVYGECPQECACEEAK"
     gene            complement(17896..19782)
                     /locus_tag="KNP36_002612"
     CDS             complement(17896..19782)
                     /locus_tag="KNP36_002612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH-quinone oxidoreductase subunit NuoF"
                     /protein_id="HBF0874473.1"
                     /translation="MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTG
                     CTSSNSLEIVSELENEIKKSGIQDKVSVRLTGCFGFCAQGPIVKVYPDNVFYVKVEPS
                     DAEKIVQSHLIRNTVVEELLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSI
                     EEYIANDGYLALGKCLTSLTPQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPT
                     DKKFVVCNADEGDPGAFMDRSVLEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSI
                     ERLKVAIAQAEKYGLLGENILGTGFNFKLELKYGAGAFVCGEGTALMHSIEGRRGEPR
                     MKTYSSSKSGLWKSPTCLNNVETFANIPAIILKGGDWFANLGTEDSSGTKVFALGGKV
                     ENVGLVEVPMGTTLRDIVFEIGGGIPEGKKFKAVQTGGPSGGCIPTEHLDTPIDFGSL
                     SSIGSMMGSGGMLVLDESDCMVDIAKFFLEFTVEESCGKCTPCRIGTTRLLEILTKIT
                     EGNGTLQDLDDLENLAETIQTASLCGLGKAAPNPVLSTLQYFKDEYIAHVVDKKCPAG
                     KCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVKEQHTIDTSKCLKCGACIDNCTFNA
                     IIKK"
     gene            complement(19799..20296)
                     /locus_tag="KNP36_002613"
     CDS             complement(19799..20296)
                     /locus_tag="KNP36_002613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase subunit E"
                     /protein_id="HBF0874474.1"
                     /translation="MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLP
                     KEVQLHVARKLGVAPAKVYGVVTFYSYFTTEPVGKYKISVCLGTVCFVKGADKILSAF
                     EKQLGIKVGETTSDFKFSLEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRE
                     LELNC"
     gene            complement(20614..22095)
                     /gene="cls"
                     /locus_tag="KNP36_002614"
     CDS             complement(20614..22095)
                     /gene="cls"
                     /locus_tag="KNP36_002614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HBF0874475.1"
                     /translation="MFDISFFEMSIYEIAVTTIYIINFMVILNLIFREKRNINTTLTW
                     LLILVLIPALGFILYIAFGRNISKNNMFRLKEKDDKIIKSNILDTQVKLQSTSEIDSD
                     IHQHKDMIYALANSNNAHYTNNNDVWIYAESSQFFNSLLEELKKAKKYINIQFYIFKD
                     DKIGTEIIDILIDKAKEGVEVRLLFDAVGGRTLKNSTLSRLKESGVKVGSFFPSFLKI
                     VNFNLNYRNHRKIVVIDGKVGFVGGYNVGDEYLGRNPKFGLWRDTHTKLTGDCVIDLN
                     MRFILDWRYTTKEDLDLEKYFIEEDTNSNHPSENIGIQIVSSGPDISELDEIKYGYLK
                     MIQKARKYIYIQSPYLILDSTFIDTLKIACLSGVDVRVMIPSKPDHPFVYWASYSYAG
                     ELLKFGAKIYTYGQNAFLHAKTIVIDDSICSIGTANMDIRSFELNFEVNAFMYSSKKA
                     LEQRIIFENDILNSKEITLDIYNSRSTYIKIKESISRLLSAVL"
BASE COUNT         8508 a         2966 c         3696 g         6964 t
ORIGIN      
        1 ttttttgggt aaatttataa aaattaaaaa atttttattt tttatgttta aaccttgtaa
       61 atttgggaca taatataatt gtaaaactta atatagcaaa aataaattac tcaatctccc
      121 ccacttaaag acctctatcc cccatagagg tcttttttac tttcaaacca aattatataa
      181 aaaataaata gttttatatg actcttcata aattaaaatt acattgtgat agcaaaccat
      241 gaatatgaaa aatatagaaa attatagcta acataagctg tatatcatct taacttcagt
      301 atatttaaca aaaaatgttt ataatttaac ctttatttta ataagtttac catatattca
      361 ctttgtctta atatatcctt tacaaattaa gagtattatt aatctataag taaatcgtag
      421 aattaaatta aatattttgg gaggataaaa atggcagata taagactaga aaatgtaaca
      481 aaatcttata ataaaaaaaa tacagttata gaaaatttaa atcttactat agaagatggt
      541 tcttttacag tattggtagg cccaagtgga tgtggtaaat ctactacgtt aagaatgatt
      601 gcaggtcttg aagatataac ttcaggtagg ttgaagattg aagaaaatga tgttacaaaa
      661 acggatgcta gtaaaaggga tatagctatg gtatttcaaa attatgcatt atatccacat
      721 atgactgtta gagaaaacat agaatttggt cttaaaaaca aaaaagtaga aaaagaaaaa
      781 agagaaaaac ttataacaga agttattgat gtagtaggat tgagagaata tttaaatgtg
      841 aaaccaggca acttatctgg aggtcaaaga caaagagtgg cacttgctag agctatggtt
      901 aaaaatccaa aggtattttt aatggatgaa ccattgtcaa atttagatgc taaattaaga
      961 aatcaaatga gaacagaatt aatacaatta catcaaaaac taaagtctac atttgtttat
     1021 gtaactcatg accaggttga ggcaatgtca atggcagata agatagttat aatgaacaaa
     1081 ggaaagataa tgcaaatagg ttctccaaag aagatatatc aaaatcctaa aaatttattt
     1141 gtagctcaat ttatagggag tccttgtatg aacatactag atataaaaaa tgatattaaa
     1201 tttggattca gaccagaaaa agcaacacta gagagtataa acatagatgg gaaaaatgat
     1261 gatgtattta gtctatttgg aaaagttgta actaaagaag tgttgggaaa tgaaactata
     1321 tattgtttat ctgttcttaa tagagagata agagtcaaaa cggaaaatga tatatttgat
     1381 attggaagaa ctttaagaat aagtgtatta gaaaaagatt tatattattt tgataaaaat
     1441 ggagaaagaa tagaagatgt aaaagtatgt aaaagtatgt attctaaaat caaaggagat
     1501 atttatgaaa aagcaattta ataaagcata tttatatata acacctgcta ttataggaac
     1561 tttattgttt atagtctatc caataattaa gacgatatct ctaagcttca aatctggtag
     1621 tcttcttagt tcaacctttg aaaatgtagg cttaaacaat tatacagaac ttttaaagaa
     1681 tccagagttt atacaaacta taacaaacac tgcaatttat acttttttta tggtgactat
     1741 atctatatca ctagccatag tacttgctgt ttggctaaat aaaaattcta taatacacaa
     1801 tttaacgcaa agtataatct ttacaccaca tgtaatttca ctagtatctg tagctgtatt
     1861 gtggctttgg attatggagc cacaatatgg ctttttaaac tggatactat cgacattaca
     1921 tttaccaaca tcaaagtggc tttcaagtga aagttcagct ttaatgtcac taattctaat
     1981 aggaatatgg aagactcttg gatataatat cttaatagtg ttatcaggtc ttaaatccat
     2041 accaaactat atatatgaag catctaaatt agataatgca aacaaaataa cgaatttctt
     2101 taaagtgaca ttgccactat tatcaccaac aatatttttt cttatgataa caacaacaac
     2161 tgcatctttt caagtatttg atgagataag tataatgaca caaggtgggc cagtgggttc
     2221 aactaacatg ttatcttatt atatatatga gtctggattt atatactatg acatagggca
     2281 agcgagtgca gcgagtatgt ttttgttagc tatagttatg attgctacat atgctaactt
     2341 tagactctta tcaaagaaag ttcattatca ataaagaaaa agtagatatt ataaggttta
     2401 tccaaaagga ggagacaatg gatattatac aacctatcaa aaaagacaaa gttgatataa
     2461 aaaaaatagc atcaaaatca atagaaatat taattctatt acttttatct gcaatattta
     2521 tattcccttt tatatggatg ctatctacat cctttaaaaa tccacaagaa atgatgcaat
     2581 taccgcccac tattatacca aatgatatag tgttagaaaa ttatagtaca gcatggcatt
     2641 caggtccatt ttttagatat ttgctaaaca gtgtatttgt aacaggaagt gttttaattg
     2701 tacaattttt agttatggtt ccagcagcat atgcattttc taagattaaa tttaaaggtg
     2761 aaaaaatgct atttgggctt ttgcttgtag gacttatgat tccaccacaa gtaacttttc
     2821 taccagtcta tatgatgatg agtaagtttg gatttataaa tacttatgtt ccacttataa
     2881 ttccatttat gacatcttca tttgggatat ttctgcttag acagaatttt atgcagattt
     2941 cagatgaaat tattgaagca gctaaactag ataatgcttc tgacttaaaa ataatgttta
     3001 gaataatggt tcctatggca aaaccagcag taataacatt tatattattt aattttatat
     3061 accattggaa taattatttc tggcccttag taatgacaaa tacagatgca ataagaactt
     3121 taccaatagg agttgcgctc cttaaatctt cagaaggaat tactgcatgg aatgtaataa
     3181 tggcaggaaa tataattcta attttaccaa taattcttgt ttatatattt gcgaataaaa
     3241 aagtaaaaga agcttttatg tattcaggaa taaaataaaa aattaaagac taaatttgga
     3301 ggatgaaaat gaagcttaaa agaaaattag caacaggatt agcaataaca ttattattat
     3361 gttctttagt tgggtgttca aattctaatg atgcaaatgc atctaaagga gaaaagactg
     3421 atagcaatat tacgaagata gatttctggg ctcctttagg tggaactaat ggagaaactg
     3481 ctcaaaaaat ggttgaccaa tttaatagtg aacataagga tgtacaagta aatatgttaa
     3541 aacagaaaga ttactatgaa aatgcaacaa aactacaggc agccttaaca tctaaagacc
     3601 aaccagatgt aacattatta gaaataactc aaacaggtac attcgcatca gcaggtgctt
     3661 tagtagatat gagtaaatat tttgataaaa catatcaaga aagattcttt tctggtcttt
     3721 taacaaattc atattatgag gataagtttg ttggtatgcc atttaataga agtacaccaa
     3781 tattatacat aaataaagat atggcaacta aagcaggtct tgacccttca ggtccaaaat
     3841 catgggaaga gcttaaggat tatgctagta aaatgacaaa taaatcagaa gatacttatg
     3901 gttttgaaac accaatagat atttggttct atgaagctat ggtaatgcaa agtggaggag
     3961 aaataactaa tggtaaaaaa gtagcattta ataatgaggc aggacaagca ccagttaagt
     4021 tctggcaaga tatgatgaaa gctggaataa tgaaaatgcc tcctggagaa gattataatg
     4081 cctgggacgt agcaaaacaa gattttgtaa atggtaaagt aggtatgata tttacatcaa
     4141 cagcagattt agcaggactt atgcaacaaa cagaaggtaa gtttgaaata tcaacagcat
     4201 tcttaccaaa aaatcaaaaa tacgcaactc ctacaggtgg agctaatcta gttatgcttg
     4261 aaggtggaac agataaagaa aaagaagcaa gtgcagaatt tatagaatgg atgacacaaa
     4321 cagataaaat cgttcagttt agttcatcaa caggatactt accaacaact gaagatgcaa
     4381 caaactcaga aaagttacaa acattatata aagaaaaacc tcaatataag gttgcaactg
     4441 accaattaca atatgctgtt gcacttccaa tgttaaatgg atacaaggaa gcaactgata
     4501 agctaatgga tgagattaaa aaggggctta ctgatttaaa tgcaaatcca aaagatgtag
     4561 taagcaaagg aacttctgca atgcaagcag taatagataa aacaaataaa taattatata
     4621 gacttgtaag ttgattaaaa gtattcaata atatataaat gaagaggtaa tgtaaatgac
     4681 aaaggttata gtattatcag tagattcttt atttgaaaaa gacttggaat ttgtaaaaaa
     4741 tctaccaaac tttaaatcta tactagaaaa ttgctccata gtaaaaaata taaattgtgt
     4801 ttatcccact ctgacatatc cgtgtcatac tagtatggtt acaggagtat atcctaaaaa
     4861 acatggtata tatcataatg aaaaatttga cccaaataaa gaaaataaag actggtactg
     4921 gtactcaaag gacataaaag caaaaactat tatagatgta gcaaaagaaa ataatctaac
     4981 tacctctagt gtattatggc ctgtaatggg agcaaatcca aatatagatt ataatattgc
     5041 agaaatatgg gctcctagta gagaagatga cccaagagaa acttttgaac gaagttccag
     5101 taaggttata atggacggta tttacaatag acattgtcat tatatcgatt ggaaattaga
     5161 acccaacatg gatttatttg gagtaaactg ttcagtagat ataataaagg aatataaacc
     5221 agatttaatg ctaatacatt tagctacatt ggaccataca cgacacaatt atggcttatt
     5281 taatgacgaa gtagataaag cattaaaaat gaatgataaa tggctaggag atattattca
     5341 ggctacaaag gatgcaggta catacaaaga tacaaatttt ataatacttg gggaccatgg
     5401 tcatcttaga gttgataaag ttataaatcc aaatgtcttg cttaaatcaa atggatttat
     5461 aaaagttgaa aatggagaag ttaaggattt tgatgcctat gtaaattctt ctggaatatc
     5521 agctcaaata atagtaaata acttagatag gttaacagag ttaagagaac tgcttgaaga
     5581 atttaaagaa gaattattca tagagaatat ttttaccaaa gaggaagcat ctaaccttgg
     5641 tcttgaaggt gattttgaaa tggtaattga aggtcttgaa ggaatttcat ttggaaatga
     5701 tttcgaagga agtattataa aagattcaga tataaaagat tacaagtttg ctgttgcgac
     5761 acatggtcat ttacctacta aaggtaatag acctccattt atagcttttg gaccaaatat
     5821 taaaggtggt gtggttatag aagaaggaga cctgagagca catgcagcaa ctatattaaa
     5881 aatgtttaat ttaaaattag atggagttga aaaagaagca tttgatttta ttatgtaagt
     5941 tgaataaagt atttattttc catgaattat agacttctat tgcaaagata gaagtctttt
     6001 tttatgtttt agatttaagt aaaatttaaa tgggtaaaat atttaaaata acttaaacaa
     6061 ttttataaag gtatgatata ataatacatg tcaggaacta atgttcgaaa aaaggagtga
     6121 tactatggat tttaaaataa aatcagactt caaacctaca ggtgaccaac cagaagctat
     6181 taaatcaata gtggattcta taaatagaaa tgagaaattt tcgacattat taggtgtaac
     6241 gggttcagga aaaacattca caatggcaaa tatcattcaa caagttaaga aacctaccct
     6301 aataatggct cataataaaa ctctagcagc acaactttac agtgagttta aagaattttt
     6361 cccagacaat gcagttgaat actttgtaag ttactatgat tattatcaac cagaagcata
     6421 tgtagctcac agtgacactt atatagaaaa agatgcaagc ataaatgatg aaatagataa
     6481 acttcgacat tctgctacag catctatttt agagagaaga gatactataa taatatcatc
     6541 tgtatcttgt atatatggac ttggtgaccc aaaagactat aaagaactta tgttatctat
     6601 aagaccaggt atgcaaagag acagagatga tgtaataaaa aggttaatag agatacaata
     6661 cgaaagaaat gacataaact ttacacgagg tacctttaga gttagaggag atatactaga
     6721 aatattccca gctagtaatg atgaaaaagc aataagaata gaattttttg gtgatgaggt
     6781 agatagaata acagaaattg attatgtaac agggaagatt gttggtacta gaaatcatgt
     6841 tgttatattc ccagcatctc actatgtaac aacgccagaa agaattgaaa aggcaattgt
     6901 agaaatagaa aacgagcttc aagaacaaat taaatttttc aaggaaaatg ataggctatt
     6961 agaagcacaa agaattgaac aaagaactaa gtatgatata gaaatgttaa aggaaatagg
     7021 attttgtcag gggatagaga actattctag acatattaca ggaaggtcag aaggagaaag
     7081 accatatact ttaatggatt tcttcccaga tgattatttg ataattgtag atgaggcaca
     7141 tgtcactata ccacaagtaa gaggtatgta tgcaggagac aggtctagaa aaacatcact
     7201 tatagagaat ggttttagat taccttctgc acttgacaat agaccattaa attttcaaga
     7261 atttgaagga aatataaatc aaatgttgtt tgtaagtgct acaccagggc cttatgaaat
     7321 tcaacactca gagacaatag cagaacagat aataagacca actggccttt tagacccaat
     7381 tgtagaagta agacctataa ataatcaaat agatgatttg gtaggagaaa taactaaaac
     7441 tatagaaaaa aatgaaagag tgcttataac cactttaact aaaaaaatga gtgaggactt
     7501 gactaactat cttaaagaaa tagggataaa agttaaatat ttacactcag atatagttac
     7561 attagaaaga acagaaataa taagagattt aagattaggg aagtttgatg tccttgtagg
     7621 aataaactta cttagagaag gattggatat accagaagtt tcacttatag caattttaga
     7681 tgcagacaaa gaaggtttct tacgttccga aacagcttta atacagacta ttggacgtgc
     7741 agctagaaat gaaaatggaa gagtaattat gtatgcagac aggataactg actcaatgca
     7801 aaatgctatt gatgaaacaa agagaagaag agatatacaa aatttatata atgaagagca
     7861 caatatcatt cctaaaacta tacagaaaaa tataagagat agtatagaag ctactaaggt
     7921 tgcagaggaa gaagttgtat atggaatatc tgatacagat gataaagacg aaataagagc
     7981 taatatagat aaattaaaat cagagatgat ggaagctgct caaaacttac aatttgaaag
     8041 agcagcagaa cttagagata aagtgaaaca attagaagaa aaattggaaa aatagaaagg
     8101 taaaaacaac attatggaag ataaaattat aataagagga gcaaaagaac ataatttaaa
     8161 aaatatagat ttagaattac caagagataa atttattgtt tttacaggtt tgtcagggtc
     8221 tgggaagtct tctttggcat ttgatacaat atatgcagaa ggacagagaa gatatgtaga
     8281 aagtctatct gcttatgcaa gacaattttt aggtcagatg gaaaagccaa atgtagaata
     8341 tatagagggt ttatcaccag ctatctcaat tgaccagaag actacctcaa aaaacccacg
     8401 ttctacggtt ggaacagtaa cagaaatata tgattatttg agactattat ttgcaagagt
     8461 aggagatgtg tattgcccta catgtggtga aaaaataagt cagatgacta ttcaagaaat
     8521 agttgataaa atgctagatt ttccagatag aacgaaatta caaattcttt caccaattgt
     8581 tagaggacaa aaaggtacac ataaaaaagt ctttgataat atcaaaaaag aaggatttgt
     8641 aagagttaga gttaatggtg aaaactatga agttagtgat gatataatct taaataaaaa
     8701 tcaaaaacat aatatagaag ttgtagtgga cagaatagta attaaagatg gaatagaatc
     8761 aagactagca gattcaattg aaactgcagt taagctatct gatggtcttg taatagccca
     8821 aataatagat ggagaagaaa ttcttttttc aactaaattt gcatgcccag aacatggaat
     8881 tggcatagaa gaattatctc caagaatgtt ttcatttaat gctccctttg gtgcttgtga
     8941 tgtttgtaat ggtcttgggg aaagtaaaga agttgaccca gaattagtag taccaaacaa
     9001 agatttatca ataaaacaag gtgcagtggc agcatggggt tcaacaggtg ttaatgatga
     9061 cacttattac agtaaaatga taaaaagttt agcagagcat tttaatgtat ctttgacaac
     9121 accgtttaaa gatttaccag atgattttgt ggaggaatta ctttatggta aagataatat
     9181 aattgtagag tttacttatg agtcaaaatt tggaggaact agaaattata aatcatactt
     9241 tgaaggtgta atagtaaact tagagagaag atatagagaa actaattcag attacatgag
     9301 agataagatt gaagaataca tggcagagag accatgtcca aagtgtaaag ggatgagact
     9361 taaaaaggaa gttttatctg ttttagttga tggaaaaaat ataatggaag ttacaaactt
     9421 atctgtaaat gaattgattg actttatgga aaatataaat cttacagaaa aacagagatt
     9481 tatagctcat gagattataa aagagataaa aggaagagct atgttcttaa gagatgtagg
     9541 tcttgattat ttaaatttat caagaaaagc tggaacttta tcaggaggag aagcgcaacg
     9601 tataagatta gctactcaaa taggttctgc attggttgga gttttatatg tacttgatga
     9661 gccaagtata gggcttcacc aaagagataa tgataggctt ataactactc ttagacatct
     9721 aacagattta ggaaatacct taatcgttgt agagcatgat gaagacacaa tgagagaagc
     9781 tgattatgtt atagacattg gtccaggtgc aggtatacat ggtggtgaaa tagttgcaca
     9841 gggtacttta gatgaaataa ttgaaaatga gaactcaata acgggtcaat atttaagtgg
     9901 taaaaaacaa atattgcttc ctgagactac tagagaagga aatggaagtt ttatagaaat
     9961 agttaaagca tcagaaaata atctgaaaaa tattgatgta aagttcccat taggtaagtt
    10021 tacatgcata acaggtgttt caggttctgg aaaaagtaca ttaataaacg atatacttta
    10081 caaaggtgtt gcaagtaaag tgaatagact taagcaaaga gctggtaagc ataaggagat
    10141 aaaaggaatt gaaagtatag ataaagttat aaatatagac caaagtccta ttggaagaac
    10201 acctcgttca aatcctgcta cttatacagg tgtatttgat tttataagag atatttttgc
    10261 atctactaat gaagctaaag caagaggtta taaaaaaggt agatttagtt ttaatgtaaa
    10321 aggtggtaga tgtgaagctt gtaagggtga tggaataata aaaatagaaa tgcatttctt
    10381 accagatgta tatgttcctt gtgaaatttg taaaggtgaa agatacaata gagaaacatt
    10441 gcaagtaaaa tacaaagata aaactatatc tgatatatta gatatgaatg tggaagaagc
    10501 tgttgagttt ttcgaaaata taccaaatat aaaaagaaaa ttagaaactt taatggatgt
    10561 aggactttca tatattaaat taggacagcc ttcaactcaa ttatcaggag gagaagcaca
    10621 acgtataaaa ttagctgctg aacttagtaa aagaccaaca ggaaagactt tgtatatatt
    10681 agatgaacct actactggac ttcatatggc agatgtagac aagctaatcc aagtattaca
    10741 aagactagca gatacaggaa atacaattat agtcatagaa cataatttag atgttataaa
    10801 gacttgtgat tatgtaatag acttaggacc agaaggcgga gataagggtg gaactatagt
    10861 tgcaactgga acaccaaaag aagtatctaa agttgatggt tcttatacag gtcaattctt
    10921 aaagaaatat ttttcttaag ttatataaat tgtgaaaaat tttagagcag atatacgata
    10981 aactgttttg ttataagtaa attagtcaaa tataagttgt aaatagtaat acaaagtaaa
    11041 gtccatatta ctcttcatgg ttaacattgt tttcaaatca attatagaag ggaatatggg
    11101 ctttaacttg tttaaagcac tggaaattgt ataacttttt aaaattcata ttttagggta
    11161 taattttagt ataaaattta atgttttgga gggcgagatg tttgatatac aagagcattt
    11221 aaaaaaatta ccttctgagc ccggagtata tttaatgaaa gacaaatacg accatataat
    11281 atatgtggga aaagccatat ctctaaaaaa tagggtaagg cagtattttc aatcttcaaa
    11341 aaaccataca tctaaagtaa aatctatggt taagaatata tataagtttg agtatattat
    11401 aacggattca gagttagagg cattaatact tgaatgtaat ttaataaaaa gatacagacc
    11461 aaagtataat gtagtgctta gagatgataa aacttatcca tatataaaag taactacgaa
    11521 tgaagattat ccaagaatct taaaagttag aagagttctt aaagataagg caaagtattt
    11581 tgggccctat accaatataa ctgctgtgaa tgataccttg gagcttataa gtagtacgta
    11641 tccaataaga agctgtaaaa tagatataga taaagcaata aagaataaga caagaccttg
    11701 tttaaatcta cacataaata aatgtttagg accttgtaca ggaaatgttt ctaaagaaga
    11761 gtatggaaaa atgatagaag agattataat gtgtttatct ggtaaagaag aaaaattgat
    11821 ggaactttta aaggaaaaaa tgaatgagag ttctatgaac tttagatttg aagaggctgc
    11881 tgtatatagg gataagataa agagccttga agagatgata cagaaacaaa aaatagatgc
    11941 tactgtaagt gacttaaacc aagatgtggt tgcaatggca agagctcata atgaagcttg
    12001 tgtccaggta ttttttataa gaaatggtaa gattgtaggt agggaacatt ttatattaga
    12061 aggggtaatg gatagtccaa gagcttctat attaagttca tttgtaaaac aattttataa
    12121 tgaacaagag tatataccta aagaattaat tatagaagat gagatagaag atagttctat
    12181 attagaagaa tggctgtcat ctaaaaaggg gcaaaaagta acaataagag ttcctcaaaa
    12241 gggagagaag aaaagcttag ttgaaatggt taggaaaaat gctgtagaat atcttgaaaa
    12301 attttctgat atgaataaaa gaaaatatga aaaaagtatt ggagcattgg aagaattaaa
    12361 gcaaatatta aatctagaaa agttgccaat aagaatagag gcttatgata tatcaaatat
    12421 acaaggtgta gattcgattg gttctatggt agtgtatacg aatgctaaaa aagataagaa
    12481 ggaatatagg agatataaaa taaagacagt tattggacct aatgattatg attctatggc
    12541 tgaaattgta gatagaagat taaaacatgg aaatttacct gacttgatat tgttggatgg
    12601 tggaaaagga caagttagtg cagtaaaaaa agtactagaa ctcaatgatg tagatatacc
    12661 tctttgggga atgtacaaag atgataagca tagaactaaa ggattgatat gcaaagaaaa
    12721 agaaatagaa ctagataaaa caactaattt atatagattt attgctagta tacaagaaga
    12781 agttcataat tatgcaataa catatcatag aagtctaaga aataaagttt tgacaaaatc
    12841 tatcttagat gatatacaag gaataggtga aaaaagaaag aaatcattat taaatcactt
    12901 taaagatgta gatgctataa aaaaagctac tatggaagaa cttttagaag tagatggaat
    12961 gaataaaagc attgcagata atgtttataa tttttttaga aaggaagaaa attaatggaa
    13021 actagcaata aagtatcaat aagagagata ataaaagagt tgaagttaaa agtagtatac
    13081 atgcctgatg atgtagatta ttatgtctac tctcaagata taaatagacc aggattacag
    13141 tttgcaggat attttgatta ttttgcatat gaaagaatac aaatagttgg aaagacagaa
    13201 tataattttt ttggattaat ggatagtcat attcgggaag aagtactaga tagatttttc
    13261 tcatatgaaa taccagcgtt aataatttct agagacttgg aaatcaagcc agatgtaatt
    13321 gaaaaggcta aaaaatataa aagaatactt ttgagcacaa atagaaatac cactagactt
    13381 ataaatagac tgtcaaacta tttggataat aagttagcac cacatacaac aattcacggt
    13441 gtgctagtag atatttatgg tataggtgta ctgataaaag gtgaaagtag tataggaaag
    13501 tcggaaacag cattagaact gattcaaagg ggtaatagat tagttgcaga tgatgctgta
    13561 gaaataagaa aattagatga aagtatgctt gtgggtcagt cacctgaact aataagacat
    13621 tttcttgaga taagaggaat aggaataata gatgttagaa gtttatatgg agtaggggca
    13681 atcaaaaatt ctaaaatgat agatttagta gttcatttag aagcttggga tgaaactaag
    13741 tattatgata gactaggact ggataaagaa tatgaagaaa tacttggtgt taatgtagag
    13801 aaattagttg tacctgttaa acctggaaga aatactgcta tgatattaga agtagcagca
    13861 atgaatttta gacaaagagg aatgggatac gatgcagctc aagaatttac taaaaaatta
    13921 tcaaaattaa tcgatactaa gtagtactga ataatagtgg actacacatc atttaattaa
    13981 atattgatta ggattatgtc ctacacctta taaattaaaa tcaagttgta tatataatgt
    14041 ttattaataa gatatattat ataaggataa tttaaagtac agtgttagat tataataata
    14101 ctagattaat tttatatttg agtttcatta tataacaaga aagttggaat tttttatggg
    14161 aatagaatat tttagtaaac ttttagaaag tagtactgaa aaagaattgc tcttaagtaa
    14221 aaagtcaaat aacataagta cagcaagatt aatatctttt ttgatagtga tagcagggct
    14281 tgctattgga ttttataata aaaatatagt aggtattttt gttggagttt tatcaataat
    14341 aatatttata gcactcttag ttattcatag taaagtaaaa gaagaagaaa catattttaa
    14401 aagtaagagc gaagtattaa ataagtatat taagagattt ggagatggtt ggaaggaatt
    14461 taaaatagat ggtaaagaat acttaaaaga tgaaaattcg caagcaaaag atttagactt
    14521 atttggaaga gcatcattgt atcaatatat ctgtgtagct aatacatctt atgggaaaaa
    14581 ttttttagcc aaatatttgt ggaatgaaaa tccagatgag aatataattt tagaaagaca
    14641 gagagctata aaagaacttt tatcaaaaga tgatttttct attcatattc aaacactcag
    14701 taatataatt ggtaaagagc aaaaaaacaa ttcagatagt agtatagaat cgtttataga
    14761 atatggagaa aataagaatg tgtatatacc aaaatggatg catattttta cttggggttt
    14821 accaactgca acaatcttat cttttatatt ttgtatgtta ggatttttac ctgttttacc
    14881 tgttttttta ctttttataa tccagttagg gtttagtggt tttggatatc caagacttat
    14941 gcaaactctt gctccattat tttcatttag tagaagtata caagtatatg aaaaaatgtt
    15001 tgaggtttta gaaaaagaga cgtttgagag tgcatatttg aaagaattac aagataaact
    15061 ttctaaggga agtggagttt caagaggtgt taaacaatta aattcaatag gaaatgctgt
    15121 aaacctaagg tataatcaga tactatatat aattgcctgt ggtgttttga tgtggaacta
    15181 tcattgtgca gaagctttgg agcgatggaa aggtatatat ggaaatcaaa ttagagattg
    15241 gtttgaatct attggagaat ttgaagctct aataagttta acagttgttt ctcatgtaaa
    15301 ggaaaataca tgttttccag taataaaata tgaagatact ccaagattga aagttgaaga
    15361 ggtataccac ccattaatag cagaaaaaag tgtcatagca aattcgatac aattaaattc
    15421 tcagacttgt attatcacag gttcaaatat gtctggaaag acaacatttt taagaagtat
    15481 cggtgtaaac ttagtgctgg catatgcagg tgctccagta tgcgctaaga gttttgatgc
    15541 gacctgtatg gctatattta cttctatgag aatacaagat gatgtaagtc aaggaatatc
    15601 aactttctat gctgagattc ttagaataaa atcaatgatt caatatagtt taaaagaact
    15661 gccaatgttg gttctagtag atgaaatttt taagggaact aactctgctg atagaattat
    15721 tggagcaagt gaggcagtaa agaaattatc aaaaccctgg gttataagta tggtgacaac
    15781 acatgacttt gagctatgtg acctttcagg tagcggagat gttgaagttg taaactatca
    15841 tttctcagag tactatgtag acgataaaat tcattttgac tataagataa aagatggaag
    15901 atgtaaaact acaaatgcaa aacaacttat gagaatggca ggtattcttt aattaataga
    15961 taggttaatt aataaataag tctatttaga aatataattt aatttgtgaa attaataagg
    16021 attgtcttaa attacgtaaa agtattttaa gacaatcctt ttttaagaat aaattttata
    16081 ctttgttatg actacttagc ttcttcacaa gcacattctt gtggacactc tccatagaca
    16141 caactcttat caaagtaatg agtatgaagg tatttatgag ctacatcact atttggttct
    16201 ccaaagaagt ctttataaat agcttgtaaa tcaggattct catgagattt acgaatagcc
    16261 ttatttctat ctatttcata taacgcattt gcacgtctat caactatttc agtattacca
    16321 tggtgataag gttgaccagc acctccaaca catccaccag gacatgccat aacttctatg
    16381 atatggtatt tacattctcc acttctgacc ttatccataa tctttctagc gtttttaagt
    16441 gtatttacaa tacatacatt aactgtagtt ccatcaacat ctatacttgc ttccctaatt
    16501 cctttaagac ctctaacatt agtgaagttt acattatcta aagtcttatt agttatcttc
    16561 tcatatgaag tacgtagggc agcttctaaa actccaccac ttgctccaaa tatagatgca
    16621 gcacctgtag attttcctag aggattatca aaatcttggt cttgaagatt aggtaaatcg
    16681 attgcagctt cttttatcat cttagctaac tctctagtag ttatagaaag gtcaacatct
    16741 agtattccag attcacttaa ttcttctctt gaagcttcat attttttagc tacacaaggc
    16801 attacagata caacataaag ttcttcagga ttgattccta atattttagg tgcatagtag
    16861 tttttagcta tagaaccaaa cataccttga ggagacttac agctagatgc taagtttaac
    16921 ttgtctggat aattgtgctc taagaagttt acccatgcag gacaacaact tgttaatata
    16981 ggaagatttt cacctttttg gattctttct ataaattcag tagcttcttc cattatagta
    17041 aaatctgcac caaagtttgt atcaaataca tgttcaaatc caagtgcttt taaagcagct
    17101 accattttcc ctgtagagat tgaccctggt tctaatccaa actcttcacc aatagcaact
    17161 cttacagcag gagcaacttg cactactata gtcttttctt ttttatttaa aacatcccaa
    17221 agtttaggta cattatctac ttctgttaat gctccagttg gacagacaga tatacattga
    17281 ccacagaatg tacactctgt ttcaaccata tcagagttaa agaatgtact aactaaagta
    17341 ttaaatccac gattaactcc agataatgct cctactgttt gtatgtcatt acatacagtc
    17401 tcacatcttc tacataatat acacttagaa tggtctttaa ctaaagattt agtagaagta
    17461 tctttacctg caaaagattt agaaccttga tatcttattt ttcttactcc taaatcagca
    17521 gctatagtct gtaattcaca atctccattt ttttcacaga caaaacaatc ttgtggatgg
    17581 tctgataaca ataattcaac aatagttcta cgagcattta atgctttagc actattagtc
    17641 tgaactttca taccttcctt tataactgtt ccacaagctg gaactaatcc tctctctgtc
    17701 tcaaccatac aaacacgaca agaagcacaa gtgtcaagct tatctatttc attcatatgt
    17761 aaatgacaaa ggttgtgtat ttttatattt attaatttcg cagcatctaa gatagaagtt
    17821 ccactaggtg ctgaaacgtg tttgccatta atagttaaat taactaaact cattgttatt
    17881 cctcctccaa ataagttatt tcttgattat agcgttaaat gtacaattat ctatacaagc
    17941 accacatttt agacacttag aagtatctat tgtatgttgt tccttaacag aacctgttat
    18001 acaaccagca ggacacactc tagaacattt tgtacaaccc ttacagtcat ctgttataaa
    18061 gtaagaaagt aagttctgac atttaccagc aggacatttc ttatctacaa catgagctat
    18121 atactcatct ttgaaatatt gaagagtact taaaacaggg tttggagcag ctttaccaag
    18181 accacataat gaagcagttt gtatagtttc agcaaggttt tctaggtcat ctaaatcttg
    18241 tagagtacca ttaccttctg taattttagt taatatttct aataatcttg tagtacctat
    18301 acgacaaggt gtacatttac cacaagattc ttcaacagta aactcaagga agaacttggc
    18361 tatatctacc atacagtcag attcatcaag aacaagcata ccaccagagc ccatcattga
    18421 accgatagaa cttaatgaac caaagtctat aggagtgtct aaatgttcag ttggtataca
    18481 tccaccagat ggtccacctg tttgaacagc cttaaatttc ttaccttcag ggattccccc
    18541 accaatttca aatacaatat ctcttaaagt agtacccatt ggaacttcaa caagtcctac
    18601 attttctacc tttccaccaa gagcaaagac tttagtacca ctagaatctt cagtacctaa
    18661 gttggcaaac caatctccac ccttaagtat aattgcaggt atgttagcaa aagtctcaac
    18721 gttatttaag caagtaggag atttccatag accactctta gaagaactat aagttttcat
    18781 tctaggttca ccacgtctac cttcaattga atgcattagc gctgtacctt caccacaaac
    18841 gaaagcacct gcaccatatt ttaattctaa tttaaagtta aatccagtgc ctaagatatt
    18901 ttcgccaagt aaaccgtatt tttcagcttg agctatggct acttttaatc tttctataga
    18961 ttttggatat tctgctctta tgtatatgta tcctgtatca gaacctatag cgtatccaca
    19021 tattgccata gcttctagta cactatgagg gtcaccttca agtacagatc tatccataaa
    19081 tgcacctggg tcaccttcat cagcattaca tacaacaaac tttttatctg ttggaccagc
    19141 tggatttttt gaagcagctt cccatttaga gccagtaggg aaacctgcac cacctctacc
    19201 acgaaggcca gaagttttta cctctgcaat aacttcttga ggagtaagag aagttaaaca
    19261 tttgcctaga gctaaataac catcattggc aatatattct tctatactat ctgggtctat
    19321 aagaccacaa ttttttaaag ctatacgtaa ctgttttttg tagaaagaca tttcttcttg
    19381 ttcttcaact tttttactta aagattcttc ctcatataat aattcctcga caactgtatt
    19441 tctaattaag tggctttgaa ctatcttttc agcatcagat ggctcaactt ttacgtagaa
    19501 aacgttatca ggataaactt ttacaatagg accttgagca cagaaaccaa aacaacctgt
    19561 caaacgaaca ctaactttat cttggattcc tgatttcttt atttcatttt ctaattcact
    19621 aactatttct agactgtttg aagatgtaca tccagtatca caacaaacaa gtaattctct
    19681 tcttaataca ttttccttag aataattttt tcttaagcta agattaggtt tcagctcatc
    19741 agctaaaact tttaattcat caaatgaatt tactttacgc attatttatt cacccctctt
    19801 aacaattcaa ttctaattct ctataagtat ctaatatttc gcttacttgg tcaggtttca
    19861 ctttaccata aactttacca tttacagtaa caactggagc taaaccacat gcccccaaac
    19921 atcttaaacc ttctaaagaa aatttaaaat cactagtagt ttctccaact tttatgccaa
    19981 gctgtttttc aaaagcactt aagattttgt cagcaccttt tacaaaacat acagttccta
    20041 gacagacact gattttatac ttacctacag gttctgtagt aaaataagaa tagaatgtaa
    20101 caaccccata tacctttgca ggagctactc caagttttct agcaacatga agttgaactt
    20161 cttttggaag atatccaaat ataccttggg cttcatgtag aacttgtatt aacgcacctt
    20221 cctttgttgc aagagagtca ataaatatat ctagttcgtc aaataattgc ttgttgtgtg
    20281 aaataaaatc gcacataaca aatccccctt ttctttttaa agttattatt tttcataaaa
    20341 taattaacca tgagttgacc ccaacattat gtgggtgaac aaaaccaaaa caataaagaa
    20401 agaataatat acaacaattt ctttatttat aaaaacaatg caaaaaagtt acctattaaa
    20461 aataaaaact atactagtct attataatat aaaataattc agaatagtta aaaaaaataa
    20521 aaaaaatgag ctaaattcaa taaaaaaaaa ataatacata taaaaaactt taaaaaataa
    20581 accaaaatgt aaaattttta taaaataaaa gatttataaa actgctgata atagtcttga
    20641 aattgattcc ttgattttta tataagtaga cctagaatta tatatatcta atgttatttc
    20701 cttagaattt aaaatatcat tttcaaatat aattctttgt tccaatgctt tttttgaaga
    20761 gtacataaat gcattaactt cgaaattaag ctcaaaactt ctgatatcca tattagctgt
    20821 tcctatagag catatagagt catctataac tattgtctta gcatgtaaaa atgcattttg
    20881 accataagta tagattttag ctccaaactt taaaagttct ccagcatatg aatatgatgc
    20941 ccagtataca aagggatggt caggtttaga aggaatcatc actctcacat caacaccaga
    21001 taaacaggct atttttaaag tatctataaa agttgagtca agtattaaat aaggactctg
    21061 tatgtatata tactttctag ctttctgaat cattttaagg taaccatatt taatctcatc
    21121 aagttctgat atatctggac cacttgatac tatctgaatc ccaatatttt cagaaggatg
    21181 attagaattt gtatcttctt ctataaagta tttttctaaa tctaagtctt ctttagttgt
    21241 atatctccaa tcaaggatga atctcatatt taggtcaatt acgcaatcac cagtaagctt
    21301 agtatgtgta tctctccata gaccaaattt tggatttcta cctaaatatt catcaccaac
    21361 attatatcca cctacaaatc ctaccttacc atcaatgaca acaatttttc ggtgatttct
    21421 atagtttaag ttaaagttta caattttcaa gaatgatggg aagaagcttc caactttaac
    21481 accactttct ttaagtctgg aaagtgtact attttttagt gttctaccac caactgcatc
    21541 aaataaaagt cttacttcaa caccttcttt agctttgtct ataagaatgt ctattatttc
    21601 agttccgatt ttgtcatctt tgaaaatgta aaattgtatg tttatatatt ttttagcttt
    21661 tttaagttct tcaagaagac tgttaaaaaa ttgactagat tcagcataaa tccacacatc
    21721 gttattattg gtataatgag cattatttga attagccaat gcataaatca tatccttatg
    21781 ttgatgtata tctgaatcaa tttcagatgt agattggagt ttaacctgag tatctagtat
    21841 attacttttg attatcttat catccttttc tttcaatcta aacatattgt tttttgaaat
    21901 atttctgcca aaagctatat aaagtatgaa tccaagagca ggaatcaata ctaatataag
    21961 aagccatgtt aaagttgtat ttatgtttct tttttctcta aagataaggt ttagtataac
    22021 catgaaatta attatatata ttgtagtaac tgctatttca tatattgaca tttcgaaaaa
    22081 tgatatatca aacataaaat tccctccttc aaatatttat taaaataagt aatt
//
LOCUS       DAEHWM010000071        22124 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.072, whole genome shotgun sequence.
ACCESSION   DAEHWM010000071 DAEHWM010000000
VERSION     DAEHWM010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 22124)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22124)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22124
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.072"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(297..488)
                     /locus_tag="KNP36_002615"
     CDS             complement(297..488)
                     /locus_tag="KNP36_002615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874476.1"
                     /translation="MDDFSKLKSLYEDGYRCIYHDCVDNNYTIYLKNFYTEGSETIEL
                     SSESDFSQFKDYIDGLRMS"
     gene            708..1754
                     /gene="cobT"
                     /locus_tag="KNP36_002616"
     CDS             708..1754
                     /gene="cobT"
                     /locus_tag="KNP36_002616"
                     /EC_number="2.4.2.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide--dimethylbenzimidazole
                     phosphoribosyltransferase"
                     /protein_id="HBF0874477.1"
                     /translation="MSLLESISKNIYSLDNSSIEKTKQRLDRLIHPTGSLGKIEDICM
                     QLAGIFGNENFDTSKKVIIAFAGDHGVYEEGVAPDPQNITKLQFPNFSKGLCGVGVIS
                     KFVGADVVAVDVGINCDEKLDGVLDYKIRKGTSNMAKGPAMSKQEAIRCLEIGIEIAE
                     QCIEKDYKVIGIGEMGIANTTPSTAIISVISGCDPLEVTGIGAGLKKERLKHKAEVIR
                     KAIEINNPNPTDGVDILSKVGGFEIGSMAGVILGCSANRIPVVIDGFISYAAALIAYK
                     INPKTREYMIASHLSAESGTKRALDILKLDPLLNMDMRLGEGSGAALAFDIIEASNYT
                     YKNMATFDEIDMGR"
     gene            1786..2346
                     /gene="cobU"
                     /locus_tag="KNP36_002617"
     CDS             1786..2346
                     /gene="cobU"
                     /locus_tag="KNP36_002617"
                     /EC_number="2.7.1.156"
                     /EC_number="2.7.7.62"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional adenosylcobinamide
                     kinase/adenosylcobinamide-phosphate guanylyltransferase"
                     /protein_id="HBF0874478.1"
                     /translation="MSKIILVTGGARSGKSNFAEKLCFDRNNNTAYIATSIPFDDEMK
                     DRVKKHQENRPRNWNTYEIYEDIYSIIKEIYKEHETVILDCVTLLVNNLMFEHNLNIE
                     ESSQEEINKLEQYIKEQVVKLIEEIEKTNLYFVFVTNELGMGIVPGNKLSRIYADIVG
                     RINQYIASKSNEVYFVVSGIAMKIKE"
     gene            2356..3129
                     /gene="cobS"
                     /locus_tag="KNP36_002618"
     CDS             2356..3129
                     /gene="cobS"
                     /locus_tag="KNP36_002618"
                     /EC_number="2.7.8.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylcobinamide-GDP ribazoletransferase"
                     /protein_id="HBF0874479.1"
                     /translation="MKRFILILQFLTRIPIKLNVGFDDEFYKSIVYFPLVGFVIGILS
                     YLIGWISMLLFEPFIASIIITLAGVLITGGLHIDGLGDTFDAIYSYRDKEKMLEIMKD
                     SRLGTNSLLAIMFVLLLKVGFVYDIISNNSLWVIIFMPMIARLGVMLLTYKTVTPREK
                     GMGNLFIGKLTTSMLITAIIYTLLIVALITKFIFLLPNIVLIKVLGSIIVVFVFIILF
                     KKHIYKKIDGVTGDILGCGIELSELVYLIYIYLLIFMFF"
     gene            3149..3763
                     /locus_tag="KNP36_002619"
     CDS             3149..3763
                     /locus_tag="KNP36_002619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HBF0874480.1"
                     /translation="MIRLILIRHALTNDNKKGRLSGHINSCISEEGKLQINKITRYLS
                     NENIDKVYTTPSTRTKDTVEKISKLKLLEIEEKEALREISFGDFEGRTFEEIKIKYPN
                     EFEKMIKEGNNYRYPNGESLIDSYKRVAKEIDNIILENNSNLDTKTILICSHAGTIRN
                     IITHLISGSYKYHWNFKIDNASITVLEIDGGFAVIDKMNFTDFI"
     regulatory      3830..4009
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            4139..5638
                     /locus_tag="KNP36_002620"
     CDS             4139..5638
                     /locus_tag="KNP36_002620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyric acid synthase"
                     /protein_id="HBF0874481.1"
                     /translation="MLQGTASNVGKSVLVAGLCRIFKQDGYTVAPFKSQNMALNSFIT
                     KEGLEMGRAQVFQAEAAKIEPIADMNPVLLKPSGNNKSQVIVRGKVVGEMPSSKYHDY
                     KLELVDVLKETFNSLNSRYDIVVMEGAGSNAEINLKDRDISNMGMAEIADAPVIIVGD
                     IDRGGVFASLAGTMLLLNEDEKRRVKGVIINKFRGKKELLQDGVKMLEDIIKVPVIGV
                     VPYTDIKIEDEDSVTTRFKKKMNKSDIHIEIIRTPHMSNFTDFNIFETQEDVSIRYVD
                     YGESLGNPDILIIPGTKSTIDDLTYIRKSGLESQIKNLHSQGKLIFGICGGYQMLGKK
                     LKDPYHVESEIEEVDGIGLLDTETTFEKEKTTTQVEATIVECISEYMNNLKGKKVKGY
                     EIHMGITKRGNDVRSLDLITKKLDKEVNYTEGSVNKEGNVIGTYLHGIFDEISFTRAI
                     LNNIRKKKGLGELESKVNSFNEFKDKEYDKLADFLREHLDIEKIYEIMK"
     gene            5677..7053
                     /locus_tag="KNP36_002621"
     CDS             5677..7053
                     /locus_tag="KNP36_002621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobyrinate a,c-diamide synthase"
                     /protein_id="HBF0874482.1"
                     /translation="MKKILIAGTNSGVGKTTISLGIMQALVKRNMKVQPYKVGPDYID
                     PSYHTFITGRHSRNLDSYMLDDEKIKYIVNKSSKDADISVIEGVMGLYDGFGIDLDNC
                     TSSHTSKVLKSPVILVINGKSMAASSAAMVLGYKELDKDVNIKGVIVNNVKTNSHYQI
                     IKSSIEKYCNVEVLGYFPPNNKFSLESRHLGLVPSVEMKSLREKFYTLADEIEHYIDI
                     DRIIEISESDEFESDFDFQTLIENNKIKEHVNNKSIAIAYDKAFNFYYRENIELLEEL
                     GLEINYFSPLEDVSVPNADYIYIGGGFPEIFGKELEANESMRTSILEAHNNNIPIYAE
                     CGGLMYLGEKLLNQEEQEFNMVGIFSGISKMTSSLKRFGYCIGVAKENTLLSKKGESI
                     KGHEFHHSIFESDEKCVYSMRKERDGNIVEEWDGGYSKGNTLATYLHTHFYNNLNCIE
                     NFLKKGNE"
     gene            7054..8025
                     /locus_tag="KNP36_002622"
     CDS             7054..8025
                     /locus_tag="KNP36_002622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin biosynthesis protein"
                     /protein_id="HBF0874483.1"
                     /translation="MSILSIYIGYVTDLIVGDPYSFPHPVRFIGKLINFTQGIIRKVS
                     KNDRQLKFGGFILWFITVGITYLTTYAIVKLFSFNILLSIVVNSFIIYTTLATKCLKD
                     EALKIYNVLKTEDIEKSRIQLSYIVGRDTTNLSEPEIIRATVETVAENTVDGIIAPMF
                     YAFIGGAPLAMAYKAINTLDSTVGYKNKKYKDIGFASAKIDDIANYIPARISVILMTI
                     GSFFLNYNYRNCFKISIRDRKNHKSPNCAFSEGAVSGALGIQLGGTNVYFGEKVYKPT
                     IGDKLREIDKEDIIKTNKIMYASSFVSMLVFTLIYVLCRMILINLII"
     gene            8057..9127
                     /locus_tag="KNP36_002623"
     CDS             8057..9127
                     /locus_tag="KNP36_002623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBF0874484.1"
                     /translation="MKDLGHGANVDEMARLYGKNPKEIIDFSSNINPNVLPNLERYIL
                     KGLEECRNYPDINYTNLRENISKYIDINPDFIIPGNGATEVIYLLMKSIKKKLAIINP
                     TFSEYRRSAELNNLDIIDLELDLENNFKLNIDIIKENIKRFDSLFICNPNNPSGNVQD
                     LKELVHLLDKHNKVLIIDETFMEFVEDESKYSLVKYIESNKNIFIIKAVTKFFGMPGL
                     RLGYGLTSNTEIMNKIYEHKEPWTINSFADILSNFIFEDKEYIKNSKEYYIEERKYML
                     QELRNIRNIKVYDTDANFILIRIYKKTTKELKKDLFKQGNILVRDASNFIGLDDSFIR
                     VAIKSHEDNKILIENMKNLLGD"
     gene            9129..10016
                     /locus_tag="KNP36_002624"
     CDS             9129..10016
                     /locus_tag="KNP36_002624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalamin biosynthesis protein"
                     /protein_id="HBF0874485.1"
                     /translation="MKSYGICPASCGEFVQGIIDDEEYLCSYAIDMYSKVYIEEKLVD
                     INLGRYKSRLAIEKVFEKFNLPKKYTKNISLNINSKIPVGKGMASSTADIGATIKATL
                     SLIDKDLSSEEISKLAAEIEPTDSIFIDKNSIFNPLNGTVIKYLGNLTNAKVVILEPN
                     KVLDTMKIRLRQDYNKLKVENKEVIKKSFALLEEGLKKNNLSLVGEACTLSSLANENI
                     EKKEYLNEIIKISKKYGAYGVNIAHSGTVVGILIDKFMNDKKMIDALCESNINSVYNK
                     IYTQNIINGGIKGEIEWNT"
     gene            10004..10636
                     /locus_tag="KNP36_002625"
     CDS             10004..10636
                     /locus_tag="KNP36_002625"
                     /EC_number="5.4.99.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003724727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-8 methylmutase"
                     /protein_id="HBF0874486.1"
                     /translation="MEYIKNPMKIEEKSFELIQEIIDEIRPDYKFKNNIEEKIIKRAI
                     HTTADFDYLDILKISEEAVDSIIDALKNNASIYTDTNMALSGINKRKLESLGCKYKCL
                     VADDETVKLAKEKGITRSMAAVEIAAKEEGRKIFVLGNAPTALYKVMEMKSEGRLDLD
                     AVIGVPVGFVGAQESKDEVEKTDIPYIISKGRKGGSNLAAAIVNAILYTM"
     gene            10645..11871
                     /locus_tag="KNP36_002626"
     CDS             10645..11871
                     /locus_tag="KNP36_002626"
                     /EC_number="2.1.1.195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-5B (C(1))-methyltransferase"
                     /protein_id="HBF0874487.1"
                     /translation="MEEYVYIDGKKYRRGYTTGSCATGASKAAVYMLITKNRINTINI
                     DTPKGIPLLLKVDNINISDTFVECSIKKDGGDDIDATHTMDIYARAEIVAKNDKNKGY
                     LTLKDIDNLSTNSECKSELYKFIRVYGGTGIGVVTKKGLSVDVGKPAINPTPLKMINH
                     EIRKLIGDNFESILGNDKVLKITIFAPQGETVAKKTFNPRLGIVGGISIIGTTGIVEP
                     MSDEGWKKSLSIELQMKKEQGLDKIILVPGNHGEQFIREKLNLDIKYVVRVSNFIGYM
                     IKEAQRIGYKKILMAGHIGKFIKVSAGIFNTHSKVADARSEILVANLALMGARYEFLN
                     KINQCVTTEEAVELINNSEYREVYNILSNKCRERVKQYLNEDSDDIDVEVIIFSMDKS
                     LLGKSDNTDDLVEVFI"
     gene            11868..12476
                     /locus_tag="KNP36_002627"
     CDS             11868..12476
                     /locus_tag="KNP36_002627"
                     /EC_number="2.1.1.289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-7 (C(5))-methyltransferase"
                     /protein_id="HBF0874488.1"
                     /translation="MINIIGLGPGNLDYITKKGENLISTSDVLIGGKRNLESIKNFEG
                     EKIVLDSNLREIIEYINNNKEKQISIIASGDPLIYGIGRYLSKNIDNKMLNMVSGISS
                     LQYIFSKIYVDMNDVYITSSHGKVPDFDYILSHKKVCMVTDSKIGPKQISREIIDRNL
                     NKIIVVGENLSYDNEKITIAKPEEIIRMDNFDMNVVVILDEE"
     gene            12466..13041
                     /locus_tag="KNP36_002628"
     CDS             12466..13041
                     /locus_tag="KNP36_002628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="decarboxylating cobalt-precorrin-6B
                     (C(15))-methyltransferase"
                     /protein_id="HBF0874489.1"
                     /translation="MRNSEFITGKVPITKEEVRAISISKLNLVNAKNLIDIGAGTGSV
                     SVEAAYNYPNLKVISIEKNDDAIELIEKNKKKFNLKNIEVIKGYAPINLGLNVKVESI
                     FLGGTGNNLEEIIEWSKKNLVTGGRLVANFIIIDTFNQTLKLLKKHGFKEIDVCVLNV
                     SKLEKLGKGEYFKPLNPIYIISCEKGENDDE"
     gene            13034..13786
                     /locus_tag="KNP36_002629"
     CDS             13034..13786
                     /locus_tag="KNP36_002629"
                     /EC_number="2.1.1.271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin-4 methyltransferase"
                     /protein_id="HBF0874490.1"
                     /translation="MNKVHFVGAGPGDKELITLKGYKLLSNADVVIYAGSLVNPELLE
                     YCKEDCQIHNSAHMDLQEIIDVMREGIENNKSVVRLQTGDFSIYGSIREQVEDLNKLN
                     IDYDCTPGVSSFLGAASSLGVEYTVPEISQSVIITRMEGRTPVPEKESIQSYAKHQTS
                     MVIFLSVQEIEKVVSKLLEGGYPKDTPIAVIYKATWADEKIVKGTLSDIAVKVKENNI
                     NKTALIMVGRFLGEEYNNSKLYDKDFKHEYRG"
     gene            13770..14891
                     /gene="cbiG"
                     /locus_tag="KNP36_002630"
     CDS             13770..14891
                     /gene="cbiG"
                     /locus_tag="KNP36_002630"
                     /EC_number="3.7.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-precorrin 5A hydrolase"
                     /protein_id="HBF0874491.1"
                     /translation="MNIEGNIAIICITENGKKLALKINSLVNNCVIYQVKNKKSNLVV
                     EETCVHTVQKKLSDFVGEIFSKFDYIVFIMATGIVVRSIAPYIISKFSDPAILVMDEK
                     GKNVISLLSGHIGGANSLTQYISSLIDANPVITTATDINQKASLDMIAKKLNAHIDNF
                     RESVKEVNSMLVNNKCVGLYVDEGYQVDTRGFKLIESKDELRDSFSNTYIEKLVVVSN
                     KINCIEDIENLNLDNKFEHCYSTQKIIKVIPRDIVIGIGCRRNTDSELMYNSLEEFLN
                     KQNIDIRAINTVGSIELKKDEKAIIELSKILKVPFKTFSVDEISKVDNLFDKSDFVKK
                     NVGVYSVAEPVAYLLSKGNLLVEKHKYKGITFSVGRIKI"
     gene            14888..15613
                     /gene="cobJ"
                     /locus_tag="KNP36_002631"
     CDS             14888..15613
                     /gene="cobJ"
                     /locus_tag="KNP36_002631"
                     /EC_number="2.1.1.131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011701973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="precorrin-3B C(17)-methyltransferase"
                     /protein_id="HBF0874492.1"
                     /translation="MIYVVGIGPGSKDTMTLEAIKAIEDSEAIVGYKTYIKLIEEFIQ
                     GKEIIQNGMRQEVDRCKQAVEEAKKGKKVAVVSSGDAGIYGMAGLILELISKEDEDIK
                     VKVIPGVTASIGAAAILGAPIMHDFCHISLSDLMTPWEVIEKRLRLAAEADFVICLYN
                     PRSKGRSEHLSKAFKIMGEFKGGDTPVGVVKDVGREKEEKFVCTFENMDFEKVDMTTM
                     VIIGNKSTYINGELMITPRGYTV"
     gene            15610..16362
                     /gene="cobK"
                     /locus_tag="KNP36_002632"
     CDS             15610..16362
                     /gene="cobK"
                     /locus_tag="KNP36_002632"
                     /EC_number="1.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="precorrin-6A reductase"
                     /protein_id="HBF0874493.1"
                     /translation="MILILGGTSDSLSICDKINELKNQPYILSVTTDYGRELAQQHAE
                     NVILGKLGKEDMLKFIKDNNIVKIIDATHPYAVEVSKTAITCAKLLNIDYIRFERKSL
                     IEEIDYDNKFIVDTIEEACEIANKIGTNIFIGTGSKNLNRFIEEISDKNLVVRVLPTS
                     EVILSCEKLGLSADNIVAMKGPFSQYINEETYKHYNIDLVITKESGIAGGFLEKVNAC
                     KTFNIPVIIIKRESINYENVFNDINKIKDILV"
     gene            16381..17859
                     /locus_tag="KNP36_002633"
     CDS             16381..17859
                     /locus_tag="KNP36_002633"
                     /EC_number="2.1.1.151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt-factor II C(20)-methyltransferase"
                     /protein_id="HBF0874494.1"
                     /translation="MKKALLVVSFGTSYHETREKTIDICEDKIKNSLKSHDFFRAYTS
                     NMIINKIKKRDGIEIDNPIQALDKIYEQGYDEVIIQTLHIICGEEFNKLKEQVDGYSS
                     KFKKIVLGRPLLTHIEDYQEAVEAIKHQIPHMESNEAVVFMGHGTLHESHSAYPALEY
                     MLRDNGINAYVGTVEGYPEIEHVIRRLKEGNIKTVNLMPFMLVAGDHAINDMAGDEED
                     SWKTILEENGFNVRVHLKGLGENSYIQDKFVRHAVKCAENAKFYGIGAGPGDGSLLTI
                     KAVNTLKKLDILYTPESKKGGDSLALSIVSEYLPESVEIKSRHFPMSFDGNEKSLAWD
                     NVAQEIISDVNDGKNVGFVTLGDPMIYSTYVYIMKRILGEVEVETIPGISSFSNIASN
                     QNFPLVMDKEALVVIPCTMEDDKIEYALQNYNSIVLMKVYKNFKEIIKKLEKYDLIEH
                     AILVSNSSQESENVFTDLKEAHLEDKISYFSTILVNKDNKIK"
     gene            17889..18794
                     /gene="hemC"
                     /locus_tag="KNP36_002634"
     CDS             17889..18794
                     /gene="hemC"
                     /locus_tag="KNP36_002634"
                     /EC_number="2.5.1.61"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylbilane synthase"
                     /protein_id="HBF0874495.1"
                     /translation="MNIVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDL
                     IQNVSLDKIGDKGLFVKEIEQQLLDGKIDIAVHSMKDMPSYLADGLKFAHTPKREDPR
                     DVLILREGYKNLDDLPHGAVIGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDE
                     NMHGIVLAASGIIRANLQDKISSYLPVDVVIPAPAQGALAIEIRSNDSTIEGIVNSLK
                     DENTEIQILAERGFLDGVNGSCHIPMAAYCEIIQDKIHLTGLYGDSEGKKVVIKSIDG
                     DISSPRELGLKLAKLVLKEYENYEG"
     gene            18784..20283
                     /gene="cobA"
                     /locus_tag="KNP36_002635"
     CDS             18784..20283
                     /gene="cobA"
                     /locus_tag="KNP36_002635"
                     /EC_number="2.1.1.107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uroporphyrinogen-III C-methyltransferase"
                     /protein_id="HBF0874496.1"
                     /translation="MKGKVYLVGAGPGDYKLMTLKGLECIRKSDVIVYDRLANSSYLR
                     EAKPDCELIYVGKASSNHILPQEDINRIIAEKAKEGKIVTRLKGGDPYVFGRGGEEAE
                     TLVDEGIEFEVVPGITSAIGGLCYAGIPITHRDHASSFHVITGHLKGDDSGELNWNAL
                     ANNKGTLVFLMGISNLEKISENLMKEGKDKDTPVALISWATRYNQRVVTSTLENVYET
                     AIKEEVKPPTLIVVGSVVGLREKLNFFESKPLFGKSIAVTRSRNQNSVLVEKIMDLGG
                     NPIEIPTIKVEKIQNNINLENEIKNINKYNYLILTSKNAVEIFFEKIYEMNFDLRILS
                     NLKVCAIGSATSNELKKRGIIADIVPKKFVAESLYEELAPILNDDDNILIPRAENARD
                     YLVDKLKAICEVTEVHIYRTVIDEEKKGEILDILNSNDIDYITFTSSSTVNNLVEIIG
                     KENIKILEKIKTLSIGPITTETINSLGIKLYKESATSTIDSLVDLIIKN"
     gene            20300..21265
                     /gene="hemB"
                     /locus_tag="KNP36_002636"
     CDS             20300..21265
                     /gene="hemB"
                     /locus_tag="KNP36_002636"
                     /EC_number="4.2.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="porphobilinogen synthase"
                     /protein_id="HBF0874497.1"
                     /translation="MLRRPRRLRASKAIRNLVRETKVNVEDLIYPLFVVEGENIKEEI
                     KSLPDVYHLSIDMLEDEIKEISELGIEHIMLFGVPDEKDECASQAFNDNGIVQKAIRK
                     VKEINSDINVITDVCMCQYTSHGHCGILTDTGYVDNDKSLEYLAKISVSHAKAGADMV
                     APSDMMDGRIQAIREALDENGLENVGIMAYSVKYASNYYGPFREAAHSAPSFGDRKTY
                     QMDPANSNEAIIETELDILEGADILMVKPALSYLDIIRRVKDNFDLPLAAYNVSGEYS
                     MLKFAVKEGLLNEDVILESITSIKRAGADIIITYFAKDIAKLLKK"
     gene            21418..21996
                     /locus_tag="KNP36_002637"
     CDS             21418..21996
                     /locus_tag="KNP36_002637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional precorrin-2
                     dehydrogenase/sirohydrochlorin ferrochelatase"
                     /protein_id="HBF0874498.1"
                     /translation="MLYPINLKLDELDVVIIGGGEVAYRKCKNFLEFNKNVTIVSKQI
                     LNKFYDLKGNIKIIKDDYKEIYIKDASVIIAATNNRELNMEIGLYCKAKNKLVNVVDN
                     IEISNFTVPSYIKRGDLLISVSTGGKSPSLSSKIKKEIEERYTEDYEEYLNVLGDIRK
                     KVIKKYEDKSKRKDVLNMLVTLDLEELKKFDI"
BASE COUNT         9103 a         2127 c         4168 g         6726 t
ORIGIN      
        1 gtatattttg aaaattttgt tttgaaaatt tgggattatt taagaaattt tgtattataa
       61 atagaaggaa atagataaat tgtatagaat aaaatatatt aagataagtt aataatgtta
      121 aatgggaagt gagtttatgg aaaaaccaaa tacaaaagtt gttaactttc aagagtataa
      181 agacagaaaa aaccaaagag aagtaaatag agacgaactt ttaaagctta taaaaaaaat
      241 tgtgacttca aaatagggag ttgttaaact ccctatttta atgggtttca taataattaa
      301 gacattctaa gtccatctat ataatctttg aattgtgaga aatctgattc actacttaat
      361 tctatggttt ctgaaccttc cgtataaaaa ttcttaagat agatagtata attattatca
      421 acacaatcat gataaataca tctatatcca tcttcataca aactttttaa cttagaaaaa
      481 tcatccacaa tatcatctcc ttaaagttct tttaaatata tttttacaaa aagcatctaa
      541 ttgtatgcaa attgacaatg taaaataaag gaaatgaaca taaaatgtag aataattttt
      601 atatgtatgt aaaaataaaa agaaaaagtt gaaattttta gaaaataaga gtatttttta
      661 tctaaaaaga gagtttaaaa aataaaaaaa tgttgggagg ataaaaaatg agtttattag
      721 aaagtatatc aaaaaacata tattccctag ataactcttc tattgaaaaa acaaagcaga
      781 gattggatag gcttatacat ccaactggaa gcttaggaaa gatagaagat atttgcatgc
      841 aattagcagg aatatttggc aatgaaaatt ttgacacaag taaaaaggtt ataattgctt
      901 ttgcgggaga ccatggtgta tatgaagaag gcgtagcacc tgaccctcaa aatataacaa
      961 aattacagtt tccaaatttt tcgaaaggtc tatgcggagt tggagtaata agtaaatttg
     1021 taggggcaga tgttgtagct gtagatgtag gaataaactg tgatgaaaaa ctggatgggg
     1081 tattagacta caagataaga aaagggacat caaatatggc aaaaggtcca gctatgagta
     1141 aacaagaagc aattagatgt ttagagatag gtattgaaat agcagagcag tgtatagaaa
     1201 aagattataa ggttattggt attggggaga tgggtatagc aaatactact ccaagtacag
     1261 caataatatc tgtaatttca gggtgtgacc cgttagaagt tactggtata ggtgcaggtc
     1321 ttaagaaaga aagactaaag cataaggctg aagtaattag aaaggctatt gaaattaata
     1381 atccaaatcc aactgatgga gtagatattt tatctaaagt aggagggttt gaaataggct
     1441 caatggcagg tgttatatta ggttgtagtg ctaataggat tccagtagta attgatgggt
     1501 ttatttctta tgcagcagca ttaattgcat ataagataaa tccaaaaact agagaatata
     1561 tgatagcatc tcatttatca gcagaatcag gaactaaaag agcattagac atattaaaat
     1621 tagaccctct attaaatatg gatatgagat taggtgaggg aagtggagct gctttagcat
     1681 ttgatataat agaagcttca aactatactt ataaaaatat ggcaactttt gatgaaattg
     1741 acatgggaag ataaatataa aaatttaata tgtaggagtg ttttgatgag taaaattatt
     1801 ctagtaacag gaggagctag gtcagggaag agtaactttg cagaaaaact atgttttgac
     1861 agaaataata atacagctta tatagcaacc tctattccat ttgatgatga aatgaaagat
     1921 agagtaaaaa aacatcaaga gaatagacct agaaactgga atacttatga aatatatgaa
     1981 gatatatatt ccataattaa ggagatatat aaagaacatg aaactgttat actagattgt
     2041 gtaacattat tagtaaataa tctaatgttt gaacacaatc taaatataga agaatctagt
     2101 caagaagaaa taaacaaatt agaacaatac ataaaagaac aagttgtcaa acttattgaa
     2161 gaaatagaaa aaacaaatct atactttgta tttgtaacga atgagttagg tatgggaatt
     2221 gttcctggga ataaacttag tagaatttat gctgatattg taggtcgtat aaatcaatat
     2281 atagcttcga aaagtaatga agtttatttt gtagttagtg gcatagctat gaagataaag
     2341 gagtagtatg caattatgaa aagatttatt ttaatactac agtttttgac aaggatacct
     2401 ataaaattaa atgtaggatt tgatgatgaa ttttataagt caatagtata ttttccactt
     2461 gtaggttttg tcataggtat attatcctat ttaataggat ggatttctat gcttttattt
     2521 gaaccattta tagcttctat aataataact ctagctggtg tcttaattac tggaggactt
     2581 catatagatg gattaggaga tacatttgat gcaatatata gttataggga taaagaaaag
     2641 atgcttgaaa taatgaaaga ttcaagatta ggtacaaatt cacttctagc aattatgttt
     2701 gtacttttat taaaggttgg attcgtttac gatataataa gtaataattc attgtgggtt
     2761 ataattttta tgccaatgat tgcaaggtta ggagtaatgt tattgacata taaaactgtg
     2821 acaccaagag aaaaaggaat gggaaattta tttataggaa aattaactac aagtatgtta
     2881 ataactgcta taatatacac attattgata gttgctctta ttactaaatt tatattttta
     2941 ttacctaata tagtgttgat taaagtatta ggttcgatta tagtggtttt tgtatttata
     3001 atattattca aaaaacatat ttataaaaaa attgacggag taacaggaga tatattaggc
     3061 tgtggaatag aactttcaga gcttgtatat ttaatttaca tatatttgtt aatttttatg
     3121 tttttttaaa gtaaaaagtg gtgataatat gataagatta atattaataa gacatgcact
     3181 gacaaatgat aataaaaaag gaagattatc aggccatata aatagttgta ttagtgaaga
     3241 gggcaaacta caaataaata aaattaccag atatctgagt aatgaaaaca tagataaggt
     3301 ttatacaaca ccatctacac gtactaaaga tacagtagaa aaaatatcaa aattgaaatt
     3361 attagaaata gaagaaaaag aagctttaag agaaattagt tttggagact ttgaaggaag
     3421 aacttttgaa gaaattaaaa tcaaatatcc aaatgagttt gaaaaaatga taaaagaagg
     3481 taacaactat agatatccaa atggagaaag tttgatagac tcttataaaa gagtggcaaa
     3541 agaaattgat aatataattt tagaaaataa tagtaattta gatacaaaga caatacttat
     3601 atgttctcat gcaggaacaa taagaaatat aataacacat ttgatttctg gtagttataa
     3661 gtatcactgg aactttaaaa ttgataatgc atctattaca gttttagaaa ttgatggtgg
     3721 atttgctgta atagataaaa tgaattttac agacttcata taatttaatc aaaaccaaac
     3781 attacaatct gtgtttgtaa tatatctgta aaattagcaa tgaaaataga atattagatt
     3841 aaaattaggt tcttaattag atgttaaaag ggaaaaaggt tagatgcctt tgcagccccc
     3901 gctactgtga aaccaacgaa actataaata ccactgtcag tttgatggga aggttataga
     3961 agtaggatga agttaagcca ggatacctgc ctaatttaat ttaaaacaag aggtcttcgg
     4021 ggtgaaagat ttttaattaa tatatataaa agtcctatct ttagaagtat taggactttt
     4081 tttaatttgt tttttagtaa attttaacaa ggagggatgg aaagtgggga aaaaaataat
     4141 gctacaagga acagcttcaa atgtaggtaa aagtgtctta gtagcaggtt tgtgtagaat
     4201 atttaagcaa gatggttata ctgttgctcc ttttaagtca caaaatatgg ctttaaattc
     4261 ttttataact aaagaaggat tagaaatggg aagagcacaa gtatttcaag cagaggctgc
     4321 gaaaatagag ccaatagctg atatgaatcc agttttatta aaaccttctg gaaataataa
     4381 aagtcaagtt attgtaagag gtaaagttgt aggagaaatg ccttcttcta agtatcatga
     4441 ttataaattg gagttagtag atgtgttgaa ggaaacattt aatagcttaa attcaaggta
     4501 tgatattgta gttatggaag gggcaggaag taatgcagag ataaacttaa aagatagaga
     4561 tatctctaat atgggtatgg cagaaatagc tgatgcacct gtaataatag tcggagatat
     4621 tgatagagga ggcgtatttg cctcattagc aggaacaatg cttttattaa atgaagatga
     4681 gaaaagaaga gtaaaaggtg taataatcaa taaattcaga ggaaaaaaag agcttttaca
     4741 agatggtgta aagatgctag aagacatcat aaaagtacct gttataggag tagtacctta
     4801 tacagatata aaaatagaag atgaagacag tgtaactacg agatttaaga aaaaaatgaa
     4861 taaaagtgat atacacatag aaataattag aaccccacat atgtcaaatt ttacagattt
     4921 taatatattt gagacacaag aagatgtaag tataagatat gtagactatg gagaatcttt
     4981 aggaaatcca gatatattaa taatacctgg aactaaaagt actatagacg atttaacata
     5041 tataagaaaa agtggtcttg aatcgcaaat caaaaattta catagtcaag gtaaattgat
     5101 atttgggata tgtggtggat accaaatgtt aggtaaaaaa ttaaaagacc cttatcatgt
     5161 tgaaagtgaa attgaagaag ttgatggaat aggtctttta gatacagaaa caacgtttga
     5221 gaaagaaaag actacaacac aagtagaagc tactattgtt gaatgtatca gtgaatacat
     5281 gaataacctt aagggaaaaa aagtaaaagg ttatgaaatt catatgggaa ttacaaagcg
     5341 aggtaatgat gtaagaagtt tagatttaat aactaaaaaa cttgataaag aagtgaatta
     5401 tactgaggga agtgtaaata aagaggggaa tgtaattggg acttatcttc atggaatatt
     5461 tgatgaaata agctttacaa gagcaatttt aaacaatata agaaagaaaa aaggtttagg
     5521 agaattagaa agcaaagtaa actcttttaa tgaatttaag gataaagagt atgataagtt
     5581 ggctgatttt ttaagagaac atttagatat agagaaaata tatgagatta tgaaataatg
     5641 atgaccttta tttataattt aggtaggagg tgtattatga aaaaaatttt aattgcgggt
     5701 actaatagtg gagtaggtaa aacaacaata tcattaggaa taatgcaagc tttggttaag
     5761 agaaatatga aagtacagcc atataaagta gggccagact atatagaccc ttcatatcac
     5821 acttttataa ctggaagaca ttctagaaat ttagattctt atatgttaga tgatgaaaaa
     5881 ataaagtata tagtaaataa gtcctcaaaa gatgcagata tttcagtaat agaaggtgtt
     5941 atgggcttat atgatggctt tggaatagat ttagataatt gtacaagttc acatacttca
     6001 aaggtattaa agtcacctgt tatattagtt ataaatggta aatctatggc agcatctagt
     6061 gctgctatgg tacttggata taaggaacta gataaagatg taaatataaa gggtgttata
     6121 gtaaataatg taaagactaa tagccattat caaataatta agagttctat agaaaaatat
     6181 tgtaatgttg aagtattggg gtattttcct ccaaataaca aattctcttt ggaatctcga
     6241 catctaggat tagttcctag tgtagaaatg aaatcactaa gggaaaaatt ttatacctta
     6301 gcagatgaaa ttgaacacta tatagatatt gacagaataa ttgaaatatc agaaagtgat
     6361 gaatttgaga gtgattttga ttttcaaact ttgatagaaa ataataaaat aaaagaacat
     6421 gttaataata aatcaatagc tatagcatat gataaagcat tcaattttta ttatagagaa
     6481 aatatagagc ttttagagga acttggttta gaaataaact attttagccc tcttgaagat
     6541 gtatcagtgc caaatgcaga ttatatttat attggaggag gttttccaga aatatttgga
     6601 aaagaattag aagcaaatga gtcaatgaga acttccatat tagaagcaca taacaataat
     6661 atacctattt atgcagaatg tggaggactg atgtacctag gtgagaaact attgaatcaa
     6721 gaagaacaag aatttaatat ggttggaata tttagtggaa ttagtaagat gacatcttct
     6781 ttaaagagat ttgggtactg tattggtgta gccaaggaaa atactctttt atctaaaaaa
     6841 ggggaatcca ttaaagggca tgagtttcat cattcaatat ttgaaagtga tgaaaaatgt
     6901 gtatattcaa tgagaaaaga aagagatgga aatatagtag aagagtggga tggtggttat
     6961 agtaaaggaa acactttggc tacatatctt catactcatt tttataataa cttaaattgt
     7021 atagaaaatt ttttgaaaaa aggaaatgaa taaatgagta ttttatctat ttatatagga
     7081 tatgtgacag acttaattgt aggagaccca tattcttttc ctcatccagt gagatttatt
     7141 ggtaaactta taaattttac tcaaggtata ataagaaagg tctctaaaaa tgataggcag
     7201 ttaaaatttg ggggatttat attatggttt ataaccgttg gaataacata tttaacaact
     7261 tatgctatag tgaagttatt tagttttaat atattattga gtattgtagt gaatagtttt
     7321 ataatttata caacactagc cacaaaatgt ttaaaagacg aagcattaaa aatttataat
     7381 gtattaaaaa ctgaagatat agaaaaatct aggattcagc tatcttatat agtaggtagg
     7441 gatactacta atttaagtga acctgaaata ataagagcaa ctgtagaaac tgttgcagaa
     7501 aatactgtag atggtataat tgcgcctatg ttttatgcat ttattggagg agcaccactt
     7561 gctatggcct ataaagctat caatacattg gactcaacag ttggatataa aaataaaaag
     7621 tataaagata ttggttttgc atctgctaag attgatgata tagccaatta tataccagct
     7681 agaatatctg tcattcttat gacaattgga agtttctttt taaattataa ctataggaac
     7741 tgttttaaaa tctctattag agatagaaag aatcataaaa gtccaaattg tgctttttca
     7801 gaaggtgcag tatctggtgc tctaggaata caactaggag gtaccaacgt ttattttggg
     7861 gaaaaagtat ataagccaac aataggggat aagcttaggg agatagataa agaagatata
     7921 attaaaacta ataaaattat gtatgcatct tcatttgtat ctatgttggt atttacacta
     7981 atatatgtgt tatgtaggat gattttaatt aacttaatta tataaattat tgtttgttaa
     8041 cttaaggggg acatagatga aggatttagg gcatggtgcc aatgtagatg aaatggcaag
     8101 attatatggg aaaaacccaa aagaaataat tgattttagt tcaaacataa atccaaatgt
     8161 attaccaaat ttagagagat acattttaaa aggattagaa gagtgtagga attatccaga
     8221 tataaattat acaaacttga gagaaaatat atcaaaatat atagatataa atccagactt
     8281 tataatacct ggcaatggtg caacagaagt gatttatttg cttatgaaga gtattaaaaa
     8341 aaaattggct ataataaatc cgactttttc agagtataga agaagtgctg agttaaataa
     8401 tttagatatt atagatttag agttagattt agaaaataac tttaaactta atatagatat
     8461 aataaaagaa aatataaaaa gatttgatag tttatttata tgtaatccta ataatccgag
     8521 tggtaatgtc caagatttaa aggaacttgt tcatttacta gataaacata ataaggtact
     8581 aataattgat gaaactttca tggaatttgt tgaagatgaa agtaaatata gtttggttaa
     8641 atatatagaa tcaaataaaa atatatttat aattaaagct gtgactaagt tttttggtat
     8701 gcctggttta aggctaggat atggtcttac aagcaacact gaaattatga acaaaattta
     8761 tgaacacaaa gagccatgga ctatcaattc ttttgcagat atactatcca attttatttt
     8821 tgaagataaa gagtatatta aaaatagtaa agaatattac atagaagaaa gaaaatatat
     8881 gttacaagag ttgagaaaca taagaaatat aaaggtctat gatacagatg ctaattttat
     8941 cttgataaga atatataaaa aaacaactaa agaattgaaa aaagatttgt ttaagcaagg
     9001 aaacatatta gttagagatg catctaattt tataggatta gatgatagct ttataagagt
     9061 ggctataaaa tctcatgaag ataacaaaat tcttatagaa aatatgaaaa atttattggg
     9121 tgattaaaat gaaatcttat ggaatatgcc cagcatcttg tggagaattt gtacaaggta
     9181 taattgatga tgaagaatat ttatgttcat atgcaataga tatgtattct aaagtgtata
     9241 ttgaagaaaa attagtagat ataaatttag ggagatataa gtcaaggtta gcaattgaaa
     9301 aggtatttga aaaatttaat ctacctaaaa aatatactaa aaatatttct ttaaatataa
     9361 atagtaaaat acctgttgga aaaggaatgg caagttcaac tgctgatata ggagctacta
     9421 taaaggcaac attatcattg atagataaag atttaagtag cgaggagatt tctaaattag
     9481 cagcagaaat agaaccaaca gattctatat ttatagataa aaatagtata tttaatcctc
     9541 taaatggaac tgttataaaa tacctaggaa atctgaccaa tgcgaaagtt gtaatacttg
     9601 aaccaaacaa agtactagat actatgaaaa ttagattgag gcaagattat aataaattaa
     9661 aagtagagaa taaagaagta ataaaaaaat catttgctct tttagaagaa ggattgaaaa
     9721 aaaataattt atctctagtt ggagaggctt gtactttgag tagcttagca aatgagaata
     9781 tagaaaaaaa agagtattta aatgaaataa taaaaatatc aaaaaaatat ggagcatatg
     9841 gagtaaatat tgctcacagt ggaactgtag taggtatttt aattgataag tttatgaatg
     9901 ataaaaagat gatagatgcc ttatgtgaat ctaacataaa ttctgtctat aataaaattt
     9961 atacacaaaa cataattaat ggaggaatta agggggaaat agaatggaat acataaagaa
    10021 tcctatgaaa atagaagaaa aaagttttga attgatacaa gaaataatag acgaaattag
    10081 accagattat aaatttaaga ataatatcga agaaaaaata ataaaaagag ctatacatac
    10141 tactgctgat tttgattact tagatatatt aaaaatatca gaagaagcag ttgatagtat
    10201 aatagatgca ttaaaaaata atgcaagtat ttatactgat acaaatatgg ctcttagtgg
    10261 tataaataaa agaaagttag aatcattagg atgtaagtat aaatgtttag tggcagatga
    10321 tgaaactgta aaattagcta aagaaaaagg aattactcgt tctatggcag cagtagaaat
    10381 tgcagctaaa gaagaaggaa gaaaaatatt cgttttaggt aatgctccaa cagctttata
    10441 taaagttatg gagatgaaat cagaaggtag attagattta gatgcagtta taggagttcc
    10501 tgtaggtttt gtaggagcac aagaatcaaa agatgaagtt gaaaaaacag atataccata
    10561 tataatttct aaaggtagaa aaggtggcag taatttagca gcagcaatag taaatgctat
    10621 attatatact atgtaggtac ctatatggaa gaatatgtat atatagatgg aaaaaaatat
    10681 agaagaggat atactacagg ttcatgtgca acaggtgcat ctaaggctgc tgtatatatg
    10741 ttgattacaa aaaatagaat caatactata aatatagata ctcctaaggg gataccatta
    10801 ctactaaaag ttgataatat aaatatttct gatacatttg tggaatgttc cataaaaaaa
    10861 gatggtggag atgatataga tgcaactcat accatggata tttatgcaag agctgaaatt
    10921 gtagctaaaa atgataagaa caaagggtat cttactctaa aggatataga taatttaagc
    10981 accaatagtg agtgtaaaag tgagctctat aagtttatta gggtttatgg cggaactggt
    11041 attggtgtgg ttacaaaaaa aggtcttagc gtggatgttg gtaaacctgc tataaatccg
    11101 actccactta aaatgataaa tcatgaaata agaaagctta taggagataa ttttgaatct
    11161 atacttggaa atgataaagt tttaaaaata acaatctttg ctccacaagg agaaactgta
    11221 gcaaaaaaaa catttaatcc aagattaggt atagttggag gaatatctat aataggtaca
    11281 actgggattg ttgaacctat gagtgatgag ggttggaaga agtctctatc tatagaactt
    11341 cagatgaaaa aagaacaagg cttagataaa ataatattgg ttccaggaaa tcatggagaa
    11401 cagtttataa gagaaaaatt aaacttagat attaagtatg tagttagggt aagtaatttt
    11461 ataggctata tgattaaaga agctcaaaga ataggatata agaaaatctt aatggcaggt
    11521 catataggta aatttataaa agtatctgct ggtattttta atactcatag taaggtagca
    11581 gatgctagaa gtgagatatt agtggcaaac ttagctttaa tgggagctag atacgaattt
    11641 ttaaataaaa taaatcaatg cgtaactact gaagaagctg tagagctaat aaataatagt
    11701 gaatatagag aagtatataa tatattaagt aataaatgta gggagagagt aaagcaatac
    11761 ttgaatgaag attcagatga tattgatgtg gaagtaatca tattttcaat ggataagtct
    11821 ttattaggta aatcggataa tacagatgat ttagtggagg tctttatatg ataaacataa
    11881 taggtctagg acctggtaac ttagactata taacaaaaaa aggtgaaaat ttaatttcca
    11941 cttctgatgt attaattggt ggtaaaagaa atttagagtc tataaaaaat tttgaaggag
    12001 aaaaaatagt tctggattct aatttaagag aaattataga gtacataaat aacaataaag
    12061 aaaagcaaat atcaataata gcatctgggg acccactaat atatgggata ggtagatatc
    12121 tatctaaaaa tattgataat aagatgttaa acatggtttc tgggattagt tcattacagt
    12181 acatattttc aaaaatatat gtagatatga atgatgtata tattacaagt agtcatggta
    12241 aagtaccaga ttttgattac atattatcac ataaaaaagt atgtatggtt acagattcaa
    12301 agataggacc aaaacaaata agtagagaaa taatagatag aaatctaaat aaaattattg
    12361 ttgtaggaga aaatctgtca tatgacaatg aaaaaataac aatagcaaaa ccagaagaga
    12421 taataagaat ggacaatttt gatatgaatg ttgtggtgat tttagatgag gaatagtgaa
    12481 tttataacag gtaaagttcc aattactaag gaagaggtta gagcaatatc aataagtaag
    12541 ttaaatttag taaatgctaa aaacctcata gacatagggg ctggtacagg aagtgtaagt
    12601 gttgaagctg catataatta tcctaattta aaggttatat ctatagagaa aaatgatgat
    12661 gctatagagc ttatagagaa aaataaaaaa aaattcaact tgaaaaatat agaagtgata
    12721 aaaggatatg ctccaattaa tctagggtta aatgttaaag ttgagtctat ttttcttggg
    12781 ggaacaggaa ataatctgga agaaataata gaatggtcta aaaaaaatct cgttacagga
    12841 ggaagacttg tagctaattt tataataata gatacattta atcaaacttt aaaactgctt
    12901 aaaaagcatg gatttaaaga aatagatgta tgtgttttga atgtttctaa actagagaaa
    12961 ctaggaaaag gtgaatattt taaaccacta aatcctatat atataatatc ttgtgaaaaa
    13021 ggggaaaatg atgatgaata aagtacattt tgtaggagca ggacctggag ataaagagct
    13081 gataacatta aaaggataca aattattaag taatgcagat gtagtgatat atgcaggttc
    13141 acttgttaat cctgaacttt tggaatactg taaagaagat tgccaaatac ataatagtgc
    13201 acatatggat ttacaagaga taatagatgt tatgagagaa ggtatagaaa ataataaatc
    13261 tgttgtaaga ctgcaaacag gtgatttttc tatatatggt tcaattagag aacaagtgga
    13321 agatttaaat aaattgaata tagattatga ctgtactcct ggagtaagtt cttttttagg
    13381 ggcagcatca tctttagggg ttgaatatac agttccagaa atttctcaaa gtgtaattat
    13441 aacaagaatg gaaggcagaa ctccggttcc agagaaagaa tcaatacaat catatgctaa
    13501 gcatcagaca tctatggtaa tatttttatc tgttcaagaa attgagaaag ttgtgtctaa
    13561 attactggaa ggtggatatc caaaagatac tcctatagca gttatataca aagcaacttg
    13621 ggcagatgaa aaaatagtta aaggaacttt aagtgatata gctgtaaaag ttaaagaaaa
    13681 caacataaat aagactgctt taataatggt tgggagattt ttaggagaag agtataataa
    13741 ttcaaagtta tatgataagg atttcaaaca tgaatataga gggtaatatt gctataatct
    13801 gtattacaga aaatggaaaa aaattagctc taaagataaa ttctctagta aataactgtg
    13861 ttatatatca agtaaaaaat aaaaaaagta atttagttgt tgaagaaaca tgtgtgcata
    13921 cagttcaaaa gaagttaagt gattttgtag gagaaatatt tagcaaattt gattacatag
    13981 tatttataat ggctacaggt atagttgtac gaagtatagc accatacata ataagtaagt
    14041 ttagtgaccc tgcaattttg gtaatggatg aaaaaggcaa aaacgtaata agtttattga
    14101 gtggtcatat tggaggggca aacagcttga cacagtacat aagtagtctt attgatgcta
    14161 atccagtaat aacaacagct actgatataa atcaaaaagc ttccttagat atgatagcaa
    14221 aaaaactaaa tgcacatatt gataatttta gagaaagtgt aaaagaagta aattctatgc
    14281 tagtgaataa taaatgtgtt ggattatatg ttgatgaagg atatcaagtt gatactaggg
    14341 gatttaaact tatagaaagt aaggatgagt taagagatag tttttcaaac acatatatag
    14401 aaaaattagt tgtagtaagc aataaaataa attgtattga agatattgag aatttaaacc
    14461 tagataataa atttgaacat tgctatagta cccaaaaaat aataaaggta attccaagag
    14521 atatagtgat aggaattggc tgtagaagaa acacagatag tgaactgatg tataattcac
    14581 ttgaagagtt tcttaataaa caaaatatag atattagagc aataaacaca gttggaagta
    14641 tagaactgaa aaaagacgaa aaagcaataa ttgaattatc aaaaatattg aaggtgccat
    14701 ttaaaacatt ttcagtagat gaaatatcta aggttgataa tctttttgat aaatctgatt
    14761 ttgttaaaaa aaatgtgggt gtgtattcag tagcagaacc tgtagcatat cttttgagca
    14821 aaggtaattt gttagttgaa aaacataaat ataaaggaat aactttttca gtggggagaa
    14881 taaaaatatg atatacgttg taggaattgg accaggaagt aaagatacaa tgactttaga
    14941 agcaataaaa gcaatagaag attctgaggc tattgttgga tataagactt atataaaact
    15001 aatagaagaa tttatacaag gtaaagaaat aatccaaaat ggtatgaggc aagaagttga
    15061 tagatgtaaa caagcagtgg aggaagcaaa aaaaggaaaa aaagtagcag ttgtaagcag
    15121 tggtgatgct ggaatatatg ggatggcagg tcttatttta gaattaatat ctaaagaaga
    15181 tgaagatata aaagtaaagg taattccagg cgttactgca agtattggtg cagcagctat
    15241 acttggagct cctattatgc atgatttctg tcatataagt ttgagtgatt taatgactcc
    15301 gtgggaagta attgaaaaaa gattgagatt ggctgctgaa gccgattttg taatttgttt
    15361 gtataatcca agaagtaagg gaagaagtga acatctaagc aaagcattca aaataatggg
    15421 tgagtttaaa ggtggagata cacctgttgg agtggtaaaa gatgtaggta gagaaaaaga
    15481 agaaaagttt gtatgtactt ttgaaaatat ggactttgaa aaagtcgata tgactacaat
    15541 ggttataata ggaaataagt ctacctatat taatggtgaa ttgatgataa ctccaagagg
    15601 ttatacagta tgattttaat tttaggagga acttcagata gtttatctat atgtgataag
    15661 ataaatgaac tgaaaaatca accatatatc ctttcagtta ctacagatta tggaagggaa
    15721 cttgcacaac aacatgcaga gaatgtaatt ttaggtaagc ttggaaaaga agatatgcta
    15781 aaatttataa aagataataa tatagtaaaa ataatagatg ccactcatcc ttatgcagtt
    15841 gaagtatcca aaactgctat tacttgtgca aaactattga atatagatta tataaggttt
    15901 gagagaaaat ctttaattga agaaatagat tatgataata aatttatagt agatacaatt
    15961 gaagaagcct gtgaaatagc aaataaaata gggacaaata tattcatagg aacaggaagt
    16021 aaaaatttga acagatttat agaggaaata agtgataaaa atttagttgt tagagttctt
    16081 ccaacgagtg aagtcatatt aagttgtgaa aaattaggtt taagtgcaga taatatagta
    16141 gctatgaaag gtccatttag ccagtatata aatgaagaaa catataaaca ttacaatata
    16201 gatttagtca taacaaaaga aagtggaata gctggtgggt tcttagagaa ggtaaatgca
    16261 tgtaaaactt tcaatatacc agtaataatt ataaaaagag aatcgattaa ctacgaaaat
    16321 gtatttaatg acataaataa aattaaagac atacttgtgt aatttttagg aggagaatat
    16381 atgaagaaag ccttattagt agtgagtttt ggtacaagct atcatgaaac gagagaaaag
    16441 acaatagata tatgtgaaga taaaataaaa aattcgttaa aaagccatga tttttttaga
    16501 gcttatacat caaatatgat aataaataaa ataaaaaaaa gggatggaat agaaatagat
    16561 aatccaatac aggctttaga taaaatatat gaacaaggat atgatgaagt aataatccaa
    16621 acacttcata ttatatgtgg cgaagaattt aacaaattaa aagaacaagt agatggatat
    16681 tcttctaaat tcaaaaagat tgtattagga agacctttgc ttacacatat tgaagattat
    16741 caggaagctg tagaggcaat taagcatcaa attcctcata tggaaagtaa tgaagcagta
    16801 gtatttatgg gacatggaac acttcatgaa tcacattcag cgtatccagc attggaatac
    16861 atgcttaggg ataatggaat aaatgcttat gttggtacag ttgaagggta tccagaaata
    16921 gaacatgtaa taagaagatt aaaagaagga aatataaaaa ctgtaaattt gatgccattt
    16981 atgttagttg caggagacca tgctataaat gatatggcag gagatgaaga agattcttgg
    17041 aaaacaatat tagaagaaaa tggatttaac gtaagagttc atttaaaagg actaggagaa
    17101 aattcttata tacaagataa atttgttcgt catgctgtaa aatgtgcaga gaatgcgaag
    17161 ttctatggta taggagcagg gccaggagat ggttctttac ttacgataaa agcggttaat
    17221 actttaaaga aactggatat tctatacact ccagaatcaa aaaagggtgg agatagtcta
    17281 gctttatcaa tagttagtga atatttacct gaatcagtgg aaataaagtc taggcatttc
    17341 ccaatgagtt ttgatgggaa tgaaaaaagt ttagcttggg acaatgtggc acaagaaatt
    17401 atatcagatg ttaatgatgg taaaaatgta ggatttgtta cattaggaga ccctatgatt
    17461 tatagtacat atgtatatat aatgaaaaga atattaggag aggtagaagt cgaaactata
    17521 ccaggaattt catcattttc caatatagca tctaatcaga attttccatt agtcatggat
    17581 aaagaagctt tagtggtaat tccttgtact atggaagatg ataagataga gtatgctttg
    17641 caaaattata attcaatagt attgatgaaa gtatataaaa attttaaaga aataataaaa
    17701 aaattagaaa agtatgattt aatagaacat gctattttag taagtaattc ttcccaagaa
    17761 agcgaaaatg tgtttacaga tttaaaagaa gcgcaccttg aagataagat atcttatttt
    17821 tctactatac tagtaaataa agataataaa ataaaatagg tgaaagcaat atttaaagga
    17881 gacttaatat gaatatagtg gttggaacta ggggtagtaa tctagcgctt atacaaacag
    17941 aatgggtaat aaatgaatta aaaaagaagt atccagaaat tagttttgag attaaaatca
    18001 taaagacaaa aggagattta attcaaaatg tttcactgga taaaataggt gataaaggat
    18061 tgtttgtcaa agaaatagag caacaattat tagatggaaa aatagacata gcagtacata
    18121 gtatgaaaga tatgccttct tatttagcag atggactaaa atttgctcat acgcctaaga
    18181 gagaagaccc aagagatgtt ctaatactta gagaaggata taaaaattta gatgatttgc
    18241 ctcatggagc agtaatagga acaggaagta aaagaaggaa gtttcaatta ttgaaacaaa
    18301 gacctgattt aaatatagta caagttagag gtaatgtgga aactaggata cgaaaaataa
    18361 aagatgaaaa catgcatggt attgtgttgg cagcatcagg aataattaga gctaatttac
    18421 aagataaaat aagttcttat ttacctgttg atgttgttat tccagcacct gcccaaggag
    18481 ctttagctat agaaattaga agcaatgata gtacgataga gggaatagta aattcactga
    18541 aggatgagaa tacagaaatc caaatattgg ctgaaagagg ttttttagat ggtgtaaatg
    18601 gaagttgtca tattccaatg gcagcttatt gtgaaataat ccaagataaa atacatctta
    18661 ctggcttata tggagattca gaaggaaaaa aagtagtaat caagtctata gatggagata
    18721 tttcttctcc tagagagtta ggtttaaagt tagctaaact tgtattgaag gagtatgaga
    18781 attatgaagg gtaaggttta cttagtaggg gcaggaccag gtgattataa actcatgact
    18841 ttaaaaggtt tagagtgtat aagaaaatcg gatgtaatag tatatgatag attagcaaat
    18901 agtagttatt taagagaagc taagcctgat tgtgaactta tatatgtagg caaggcatca
    18961 agtaatcata ttttgccaca agaagatata aatagaatta tagcagaaaa agctaaagaa
    19021 ggaaaaattg taactcgtct taaaggagga gacccttatg tatttggcag agggggagaa
    19081 gaagcagaga ctttagtaga tgaaggtata gaatttgaag tagttccagg tataacttct
    19141 gctataggag gtttatgtta tgcgggtatt cctataacac atagagacca tgcttcgtca
    19201 tttcatgtaa taacaggtca tttgaagggt gatgatagtg gagaattaaa ctggaatgct
    19261 cttgcaaata acaaaggtac tcttgtgttt ttgatgggaa tttcaaacct agagaaaata
    19321 agtgaaaact taatgaaaga aggaaaagat aaggatacac ctgttgctct tataagttgg
    19381 gcaactagat ataatcaaag agttgttaca tctacacttg aaaatgttta tgaaactgct
    19441 attaaagaag aagtaaaacc gccaactctt atagtagttg ggagtgttgt aggacttaga
    19501 gaaaagttga acttctttga aagtaagcct ttatttggaa aaagtattgc tgtaactagg
    19561 tctagaaatc aaaatagtgt attggtagaa aaaataatgg atttaggtgg aaatcctata
    19621 gaaataccta ctattaaggt agaaaaaata caaaataata ttaacttaga aaatgaaata
    19681 aaaaatataa ataagtataa ttatctaata ctaactagta aaaatgccgt agaaatcttc
    19741 tttgaaaaga tatatgaaat gaattttgat ttaaggatat tatctaattt aaaggtatgt
    19801 gctataggtt ctgctacatc aaatgagttg aaaaaaagag gaattatagc ggatatagta
    19861 ccaaaaaaat ttgtagcaga gtcactgtat gaagagttag cgcctatttt aaatgatgac
    19921 gataatatac ttatacctag agcagaaaat gctagagatt atctggttga caaactcaag
    19981 gctatttgtg aagtaacaga agtacatata tatagaacag taatagatga ggagaaaaaa
    20041 ggtgagatat tagatatttt aaattctaat gacatagatt atataacatt tactagttcc
    20101 tcaacagtaa ataatcttgt tgaaattata ggaaaagaaa atattaaaat attagaaaaa
    20161 ataaaaacac tatctatagg tcctataact acagagacaa taaatagttt gggaataaaa
    20221 ttgtacaaag aatctgctac atctactata gattcgttag tagatttaat tataaaaaat
    20281 taattttgga ggcttgaata tgttaagaag accaagaaga ctaagagcaa gtaaagcaat
    20341 cagaaatttg gtaagagaaa ctaaggtgaa tgtagaagac ttaatatatc cactgtttgt
    20401 agtagagggg gaaaatataa aagaagaaat taaatcttta ccagatgtct atcatttatc
    20461 aatagatatg ctagaagacg aaataaaaga aataagtgag ttgggaattg aacatataat
    20521 gttatttggt gttccagatg aaaaagatga gtgtgcttca caagctttta atgataatgg
    20581 aatagttcaa aaggcaatta gaaaggtaaa agaaataaat tcagatataa atgtaataac
    20641 agatgtctgt atgtgccaat atacaagtca tggacattgt gggattttaa ctgatactgg
    20701 ttatgttgat aatgataaat cattggagta tttggctaaa atatctgtaa gccatgctaa
    20761 agcaggagct gatatggttg ctccatctga tatgatggat ggaagaatac aagcaataag
    20821 agaagcttta gatgaaaatg gattagaaaa tgttggaatc atggcttata gtgttaagta
    20881 tgcttcaaat tattatggac cttttagaga ggcagctcat tcagcaccat cttttggaga
    20941 tagaaaaaca tatcaaatgg acccagcaaa tagcaatgaa gctataatag agactgaact
    21001 tgatatattg gaaggtgcag atatacttat ggttaaacct gcattatcat atttagatat
    21061 tataagaaga gttaaagata attttgactt acctctagca gcttataatg taagtggaga
    21121 atactctatg cttaagtttg ctgtgaagga aggtttatta aatgaagatg taattcttga
    21181 atcaattaca tctataaaaa gagcaggagc agatataata ataacttatt ttgctaaaga
    21241 cattgctaaa ctgttgaaaa aataaattct agcagtataa agaatatcaa aaagtatagg
    21301 aattgtaatt aactattata cagtagtttt gtttagacat ttattgaaga ataatagaaa
    21361 ctaatttgca atttctatac tttatttatg taactaaata aaatttggag gtagaagatg
    21421 ctatatccta ttaatttaaa attagatgag ttagatgtag ttataattgg tggtggagaa
    21481 gttgcatata ggaaatgtaa aaatttttta gagtttaaca aaaatgttac tatagtttct
    21541 aaacaaattt taaataaatt ttatgattta aaaggaaata taaaaataat aaaagatgat
    21601 tataaagaaa tatatataaa agatgcttct gtaataattg ctgccacaaa taatagagag
    21661 ttaaatatgg aaataggatt atattgtaaa gcaaaaaata agctagtgaa tgtagttgat
    21721 aatatagaaa tatcgaactt tactgttcca tcatatataa aaagaggaga tttacttata
    21781 agtgtgtcta ctgggggcaa gagtccttca ttatcatcaa agataaaaaa agaaattgaa
    21841 gagagatata ctgaagatta tgaggagtat ttaaatgtat taggagatat aagaaaaaag
    21901 gttataaaaa aatacgaaga taaaagtaaa agaaaagatg tgcttaatat gttggtaaca
    21961 cttgacctag aagaacttaa gaagtttgat atataaaaaa taaaataaaa aatgttaaaa
    22021 aggtgttgac ggattatttt taagatgata tagtattact tgtccttaag aaaagggcaa
    22081 acataaaaaa tgaactttga aaattaaaca gtaggttaat ttat
//
LOCUS       DAEHWM010000072        21914 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.073, whole genome shotgun sequence.
ACCESSION   DAEHWM010000072 DAEHWM010000000
VERSION     DAEHWM010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21914)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21914)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21914
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.073"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            418..1725
                     /locus_tag="KNP36_002638"
     CDS             418..1725
                     /locus_tag="KNP36_002638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874499.1"
                     /translation="MKEIADAITSEYLSYGINEDISIYEGRFCIYLDKKYRCNGKIYY
                     KMTPPISISFKADIGCVEEIDNEDDNLALDYDNAILEVHGYKIISITINTLSEFSVEG
                     YINDDCIKSKNSYVEYVDFNIINLDKIPGKLIKYNDKVYAGRIEFDINDYVVTIDKRY
                     DYRKELKSELKSKSGAIITHIGRIRRKDGRIFRTNNTINLLDRISTALSFMCGRYVGF
                     CLAKGYRSGNEVYRIWNENQISPFRYVPTWSDTLSNYHNMEKYISLMCKKLEDFYYGS
                     AIKSVVDWYIESLGSATMENNIISVQIALETLSYVILVEQNKILTDEAFDCNLASKNI
                     RLLLDTCKIPYGKHELNIFDNIIKNKFDDGVDLVIYLRNSIVHPSRKTHRAVLEVEDI
                     WNIISIGTRYIELVLLFILGYRGEYSNRLVERCYGEVEVVPWN"
     misc_binding    1811..2073
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2199..3002
                     /locus_tag="KNP36_002639"
     CDS             2199..3002
                     /locus_tag="KNP36_002639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0874500.1"
                     /translation="MKNILKKVGIFTIMLGLLGGVVGCSKPDNEKDKDASKESKKEVV
                     VGFDNTFVPMGFLDEKGDTVGFDVDLAKETFKRLGMEVKFQPIDWSMKETELNDSKTV
                     DVLWNGYSITDERKKIVSYTEPYLQNKQIIVTLSDSKINSKADLKDKEVGTQQGSTAL
                     DAVEKDKDFMNSLKGGAPVLYDTYDKALRDLEIGRTSAVVGDEVLIRYYMGQKGEDKY
                     KVLKDDFGLEDYVVATSKENPELCEKINETLKEMKKDGTFDKIYDKWFK"
     gene            3040..3651
                     /locus_tag="KNP36_002640"
     CDS             3040..3651
                     /locus_tag="KNP36_002640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBF0874501.1"
                     /translation="MLQGLEIVIAMFCITLIVSIPLGIGVAFLRLSKNKLVSGITQCY
                     ILIMRGTPLLLQMIVIFYGLPLLGIVFDRFTAGVVAFFLNYAAYFAEIFRGGIQSIDR
                     GQYEASKVLGFDKFTMYKRVIFPQVFKRILAPISNEVITLVKDTSLVYILGLNDILRI
                     SQIAMNREASLLPLFEAGAIYLIFVAILTKGFELLEKKYSYYR"
     gene            3683..4354
                     /locus_tag="KNP36_002641"
     CDS             3683..4354
                     /locus_tag="KNP36_002641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBF0874502.1"
                     /translation="MLKIKNLNKSFKKNRVLKDISFELEEGQIGVLLGKSGAGKTTIL
                     RCINGLEEFDSGEIIIDNEVIKNKRDMAKIRGKIGMVFQNFNLFPHMTVLENIIESPV
                     NVFKVPRKEAEERARELLRLVDLEDKLNSYPFELSGGQQQRVAIARSCALMPKVLCFD
                     EPTSALDIDTIQRVVNIMNRLKDKGMTILIITHDVVFSNNVADKIISIKDGIVENVQI
                     KEKIV"
     gene            4653..5015
                     /locus_tag="KNP36_002642"
     CDS             4653..5015
                     /locus_tag="KNP36_002642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HBF0874503.1"
                     /translation="MIKLYGYTKCSTVKKAKNWLKENNLEFEDIDMVQNPPSKEELKS
                     IYKTSGYDIKKFFNTSGMKYRELGLKDIVKTESDDKLLEILVSDGMLIKRPLLLDGKN
                     VLLGFKEDVWKSTLLKED"
     gene            5451..6152
                     /locus_tag="KNP36_002643"
     CDS             5451..6152
                     /locus_tag="KNP36_002643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4253 domain-containing protein"
                     /protein_id="HBF0874504.1"
                     /translation="MSIEDLYDFECVPLNNEIDIDVLFEKMIEDGKEKEYTPIIVIDE
                     KVGLLRKNIDMITKEYGSLENYREYCLTKYNEIDVNQFFDFRKSEISELLKELIDLED
                     DFYDYKHFRPIMNIDIFHEYNKVYIAKIPTIKPYEVFAYIPIGGFNDCPRDEEHIAIA
                     KYWYEKHGIFPIAIGCDTVQYSVKNLTKDGKKFDELCIELVFYCEDIIIQGYETLKAL
                     KDVLKRSTIVLFWWD"
     gene            6423..7241
                     /gene="larE"
                     /locus_tag="KNP36_002644"
     CDS             6423..7241
                     /gene="larE"
                     /locus_tag="KNP36_002644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent sacrificial sulfur transferase
                     LarE"
                     /protein_id="HBF0874505.1"
                     /translation="MEVNFVKEKEKLDKLKKMLLELGSVVVAYSGGVDSNFLLKVAKD
                     TLGENVIAVTIHAMMHSSREIEEAKQYTQNFGVKHIILNIENFDLKEFKENGVDRCYH
                     CKKYIFSKIKEVAKEHNIKYIVDGTNIDDLGDYRPGLKALSELGVISPLKDSSLKKEE
                     IRSLSKTLGLNTFNKPSFACLASRIPYGVEITDENLRIVEKSEEYLSNLGFSQFRVRM
                     HGDIARIEVGQEELGKFFENNNFNKVDTKLKIFGFKYVTLDMSGYKMGSMNLNV"
     gene            7296..8444
                     /locus_tag="KNP36_002645"
     CDS             7296..8444
                     /locus_tag="KNP36_002645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HBF0874506.1"
                     /translation="MKNYTLISPCFFGMEKMLAREITNLGYEIIKTEDGRITYKTDEF
                     GIAKSNMWLRCAERVHLKIAEFEAKSFDELFENTKRINWSRYIPYGAQFPISKASSIK
                     SKLYSTPDVQAIVKKAIVESLKKSYLEDGLLKEDKEKYPIFVFIHKDKVTISIDTTGD
                     ALHKRGYREKANKAPIRETLAAGLIYLTPWKAGRVLVDPMCGSGTILIEAAMIGINMA
                     PGLNREFISEKWRTLDKKIWWDVRKDAFNKIDNESKFKIYGYDIDEESIDIARENAEI
                     AGVDEYIEFNVGDATQFKSEDEFGFIITNPPYGERLEDKDSVKQLYKELGYAFRKLKN
                     WSYYLITSYEDFEYEFGQKADKKRKLYNGMLKTNFFQYPGPKPPRNNK"
     gene            8580..9968
                     /locus_tag="KNP36_002646"
     CDS             8580..9968
                     /locus_tag="KNP36_002646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874507.1"
                     /translation="MKVLKLITVVALMMLFVTGCNIKTESPEQLAKIPDYDDTKKVLY
                     DGIDQLLKPDSSMILPSNTKEVGKINKVDLNSDGIDELVVFEQKEDLSNNVSQVGFVT
                     LSYNGEKYVLGDHFLENGESIEYANFYDLDSDGYKEVILLVKSKDKTNMHIYKVVDNE
                     ITKIYDLDASWLQNKEDFNDMKVKIGYIDGDDKLDILMLHLNNKTNEMFASVANFDGK
                     MKIKDSVKFENVKNLSELYITLGNVASSVGNSSAAIKGIVLDIPILKDNNYITQILYM
                     KDGKINKAFSDYDKTITKSYYIPVDDIDKDKIIEIPIVAGSTGNNKNTYSSKSSATIS
                     WYRWNGKEGDDSSLIFTSQIYYNYKYNFKLFIPNNLFDKILVEQEFVGEKAVFKFYYF
                     DYSDRKNLFNIVVESKNKLEDRKNTGTQNSIVLQESDEYTFLLVVNNANEMDKLDMTI
                     DALKEYFSLIYG"
     gene            9997..10695
                     /locus_tag="KNP36_002647"
     CDS             9997..10695
                     /locus_tag="KNP36_002647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874508.1"
                     /translation="MKEKILILEDEIGIRSFVSINLKREGYEIVEAGTGREAIEKMTT
                     EKDITIALLDVMLPDISGIEVCKFIRENFDQVGIIMLTAKAQEDDKIEGFISGADDYI
                     IKPFSIKELLVRVSALLRRVAKDDSSVKSSEIVSPPFILDIDKRKLFKNGKEIELTPT
                     EFSIVKYLISNAKQSLSRDQILDEVWGTNYLYDFKIVDVNIRRIRNKIEDDPSKPKYI
                     QTIWGYGYCFRKEE"
     gene            10698..12131
                     /locus_tag="KNP36_002648"
     CDS             10698..12131
                     /locus_tag="KNP36_002648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874509.1"
                     /translation="MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQ
                     LLESEIKYADEYNAITMETTSFEKKVKNIFDKQPLTKNSEFGISIIDKDKNIILDQYG
                     FKSKEKANYEDVNNALKDIKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYT
                     VSLDAIDNAILKQATWLILAGIFILIIAILISLKFAETLIKPLRELKKFANELAVGNY
                     NIKLEKMKIVDDEIGDLAQTFEHMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSE
                     TLGYESITREELDLGLGIIQDETERLIKLVEELLDFSRLSSDRIKLHVDIVDVEGLIV
                     GVVNQLKVKAAEKDISLLFEFENEFIENIQGDKNRLRQVLINLIQNSFKFTSQGGYIK
                     VVASQDEEITTISVEDNGSGIEKQNLNKVLDKFFQEDYNKAGSGLGLAISNEIVKLHG
                     GRMKIESEKNVGTKITFNIKNKFAKQA"
     gene            12153..12890
                     /gene="truA"
                     /locus_tag="KNP36_002649"
     CDS             12153..12890
                     /gene="truA"
                     /locus_tag="KNP36_002649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011010156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HBF0874510.1"
                     /translation="MRNIKMIVAYDGSRYKGYQKLGDNNMTIQEKLENVLSKMTNETV
                     EIIGSGRTDMGAHARGQVVNFRTNCMDSLDKIQKYLYEYLPEDIVVKTVEEVDERFHS
                     RYNVKSKTYMYKIDNNKYHSPFIRKYATHVSKKLDLDRMRKASEYLVGEHDFTSFASS
                     KSKKKSNVREIYSINIKEDDNVIEIYVEGNGFLYNMVRIIVGALIDVGLKRRAPQDIK
                     YMLESKDRCQSSDTAPAKGLCLWKVTY"
     misc_binding    13001..13208
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            13461..14660
                     /locus_tag="KNP36_002650"
     CDS             13461..14660
                     /locus_tag="KNP36_002650"
                     /EC_number="6.3.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase"
                     /protein_id="HBF0874511.1"
                     /translation="MKEKVVLAYSGGLDTSIIIPWLKENYEDIDVIAVCGNVGQEDKM
                     EDVYEKALQSGASKAYVDDISEEFVTETIFKAVKAEAKYEGKYLLGTSLARPIIAKKL
                     VEVAHKEGAKYICHGCTGKGNDQVRFEATIAALDPTIKVIAPWRIWDIKSREDAIDYA
                     EKHNIKVTATKAKIYSVDANLWHVSTEGGDIEHLENEHKKDVYKQCVDPEDACDVAEY
                     VEVYFEKGVPKKVNGEELSPVALIHKLNELGCKHGIGVIDIVENRLVGMKSRGIYETP
                     GGTILYEAHNILESATLDKDTLHFKQMVSYKYGELIYNGLWYCKLRESIDAFMEQTQD
                     NVTGTVKVKLYKGNIKPAGIFTENALYDEGISSFGNSELYDHKDAEGFINLFTLPLKI
                     RAMKAGK"
     gene            14907..15953
                     /locus_tag="KNP36_002651"
     CDS             14907..15953
                     /locus_tag="KNP36_002651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4872 domain-containing protein"
                     /protein_id="HBF0874512.1"
                     /translation="MRKIIEIKHHSHDYECMWNGIEDLYINKTGECLPNDFFFLLSGF
                     GSFCYMKTNKADLKRMVALGDGRTKQMYKFLAPIVGFEYKHHEFKKYEQALKKAKSEI
                     DDGYPVILGALDMYYLPYYKKLYHKEHIPFHYILMVGYDDEGIYLYDCGRTELLHLSY
                     DKLRESMNCNSPGLSKENTICTIRMNTSKNKYNIAREAIAIKRDMFLNPPKGFLGYKG
                     FEKFIKELPQWNTELDKDDYDKILTNMVMFFGTVPTIPNAIKGIKEPDTVQFKGGFDK
                     MSRMLNSIGEEYKNDSFIQVADIFDKTAIIIEKISNIIIDYLTQTCDDTGQLPLLFSE
                     VLEHMKTGYLILDV"
     gene            16061..17224
                     /locus_tag="KNP36_002652"
     CDS             16061..17224
                     /locus_tag="KNP36_002652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0874513.1"
                     /translation="MRTVKQVSDLTGISVRALHYYDEIGLLKPNKITDAGYRLYDDES
                     IKTLQQILFFKEIDIPLREVKEIMSSQYFDKVEALKNQKKLLILKRKRLDELIELINQ
                     TLRGEGNIDFKEFDMSEYFDVLEEFKREHRNKVIKIYGSVEKYNEYIERVKSNEEKIA
                     KMAIKQYGTIEKFAKAIKTNFSSDILNLGEKFDRYKNDCLKEKHPKLKELYRKLVEDL
                     NRNPSSTDLQEIAKEITDISKKDYEIFSMDTGDDNWYYMVQNYLVNPMWIEEVDKKYG
                     SGAGKFIGQVLKTYLRDRKPKINTLYEKLVEDLSRDCSSREVQSIVEEIDNEMKRSNE
                     FYKIDNGERYFDYMSELYLQDSNYIKVTDKNYGDGASKFIGEAFKIYFDNNNC"
     gene            complement(17313..17693)
                     /locus_tag="KNP36_002653"
     CDS             complement(17313..17693)
                     /locus_tag="KNP36_002653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4363 family protein"
                     /protein_id="HBF0874514.1"
                     /translation="MKSTTFVILWTILFVLFGFYVNNKLYDFTEGYKDNISVLEKSIE
                     NEDWEKAQKEADSISTSWNKEKNHWYKVLNHEYFDEIGLRFNILDKAIYTENKLKSLE
                     EVESIKTYLGNIIESVKFDVNYIF"
     gene            complement(17696..18355)
                     /locus_tag="KNP36_002654"
     CDS             complement(17696..18355)
                     /locus_tag="KNP36_002654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HBF0874515.1"
                     /translation="MTVVLIRSIILYITVLIALRVMGKGEIAEMNCFDLVITLLIAEV
                     ASVPMENNNIPIINGVAAISGLVIMQTLISFLSLKSRKLSSFLSGKPSVLIDKGKIVY
                     KELKKERISIDELLEQLRIQGYFNLKDVQYAILETDGNLSVVPASSYNSTPPRAFNHL
                     PIPLILDGRIINKNLDIAQKDTNWLMGILKSNHIETFKDVLICVLDENDKIFIQNKKG
                     D"
     gene            complement(18461..19435)
                     /locus_tag="KNP36_002655"
     CDS             complement(18461..19435)
                     /locus_tag="KNP36_002655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBF0874516.1"
                     /translation="MKYKLFIDFEFNILDDNKNKPKEYNGAELISIGGVLVDNEFNTI
                     DNYYSLVKPKYNKILSNKCKNLTKLNQLDINNAPNLLYVMDDFYKWFCKFDDVTIYNW
                     GDFDITGLLTSFRVYKYTGKCLELFNMMIDIQPFISQHITYNNRILSKQISLLNMKKI
                     FSVEGDIKHNSLSDAVDLMNVCKCFFFNSPKNIDILEELYNKLPALKTPLYYIPYFED
                     ENFELKFDRTPEDIIIYLKQILTILNISKKEIYFKKRSVLVNNSKIINFKNLSSSFKL
                     IKLNEFEEYPDFILKLGDKKSFVESVIKINKSNRKSIKNLILKLSKKP"
     gene            complement(19475..19822)
                     /locus_tag="KNP36_002656"
     CDS             complement(19475..19822)
                     /locus_tag="KNP36_002656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874517.1"
                     /translation="MLNLKEIREEIIKKYIGDSLISELTEELKNILITDLQSNPFKSN
                     IELSIIPANIEIFKKIENILIDSKVNLKMGWERILINYILKDLFELNYEINKSCNEPL
                     MFRVIISIDSYDA"
     gene            complement(20040..20996)
                     /locus_tag="KNP36_002657"
     CDS             complement(20040..20996)
                     /locus_tag="KNP36_002657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-threonine 3-dehydrogenase"
                     /protein_id="HBF0874518.1"
                     /translation="MKKILITGALGQIGSELTIKLRNEYGEQNVIASSRRVKEGNPVC
                     ESGIFEILDVTDKNRFFEIAKKYDVDTIIHLASLLSAVAESKPLEAWNLNMNGLINGL
                     EIAKELDCKFFTPSSIAAFGENSPKNMTPQDTLQRPNTMYGVTKVSGELLCDYYHSKF
                     GVDTRGVRFPGLISYVTPPGGGTTDYAVDIYYEALKNKRYKSYIAEGTKMDMMYMPDA
                     LQSIVDLIEAPADKLIHRNAFNITAMSFSPEEIADSIKKYIPDFVIEYDVDPVRQSIA
                     DSWPNSLDSSSAVKEWNFKFSYDLDKMTKDMLEKLSEKGIGK"
     gene            21441..21809
                     /locus_tag="KNP36_002658"
     CDS             21441..21809
                     /locus_tag="KNP36_002658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C-GCAxxG-C-C family protein"
                     /protein_id="HBF0874519.1"
                     /translation="MTRPSIYHSQGYTCAEALIKSYNEEHNTDIPISIGSGMGVGMNV
                     GSVCGAVNAAVVIIGYLNGRNSNLDENIARKYSRELLNRVRNKYSSEICVSLKKNKVT
                     CEEIINFTYDALNDMLKNQK"
BASE COUNT         8682 a         2220 c         3623 g         7389 t
ORIGIN      
        1 aaaaagtaca atagtgttaa tgtgtgaatt agataaggtg tatataatag tttagatgat
       61 atgatataaa atatgttgta aattaaatgt tttctttgac aatatataca caaggatgat
      121 aatatctata tgaataaaag atagtgtgta atttgataat atgtaattat aacattatga
      181 tataattaca ataaagtatg taataatctg tagaaatttc aagctagtta tctaagtttt
      241 cggataacta aatctaaacg gaatacataa tgtattaaat aaatgatgat actaaaatga
      301 tactattttt atagaaattt attgaggtat ataattaatg aaaataatat attaaattat
      361 ataaattaaa ttatataata tattgagttt tacataaaag caaaggtggg aataaaaatg
      421 aaagaaattg ctgatgctat aacatcagag tatttaagct atggtatcaa tgaagatatt
      481 agtatctatg aaggtagatt ttgcatatat ttagataaaa aatatagatg taatgggaaa
      541 atttattata aaatgacacc tccaatatct ataagtttta aagcagacat aggttgtgtt
      601 gaagagatag acaatgaaga tgacaattta gctttagatt atgataatgc tattcttgaa
      661 gttcatggat ataaaattat ttctataaca ataaatactt taagtgaatt tagtgtagaa
      721 ggttatatca atgatgactg tataaaatct aagaactcct atgttgaata tgtagatttt
      781 aatataataa acttagataa aatacctgga aaactcatta aatacaatga taaggtatac
      841 gcaggtagaa ttgaatttga tataaatgat tatgttgtaa ctatagacaa gcgatatgat
      901 tatagaaaag aattaaaatc agaattaaag tctaaatctg gagcaataat aactcatata
      961 ggcaggatta gaagaaaaga tggtagaatt tttagaacaa ataatacaat aaatctttta
     1021 gataggatat caacagcttt gagttttatg tgtggaagat atgtagggtt ttgtttggcc
     1081 aaagggtata gaagtggtaa tgaagtttat agaatatgga atgaaaatca aatatctcct
     1141 tttagatatg taccaacatg gtcagataca ctttcaaatt atcataatat ggaaaaatat
     1201 ataagcctta tgtgtaaaaa gctagaagat ttttattatg gttctgctat aaagagtgtt
     1261 gttgattggt acatagaatc tcttggaagt gctaccatgg aaaacaatat aatatctgta
     1321 caaattgcac ttgaaacttt gtcatatgta attctagtgg aacaaaataa gatacttaca
     1381 gatgaagcat ttgactgtaa tttggcatct aaaaatataa gactcttact tgatacatgt
     1441 aagataccat atggtaaaca tgaattaaat atatttgata atataataaa aaataaattt
     1501 gatgatggag tggatttagt tatttattta agaaatagca tagttcatcc aagtagaaag
     1561 actcatagag ctgtgttaga ggttgaagat atttggaata taatttcaat aggaacgaga
     1621 tatattgaac ttgttttact ctttatttta ggttatagag gagaatattc aaacagatta
     1681 gtagaaagat gttatggtga agtggaagtt gtaccttgga actagatttt tatatttatt
     1741 ttaaaatata tattgacata tattgcctta tgctataaaa tcaatatcat aataataatt
     1801 cagaataaca ttaaatgcta agaaaagaaa tagtaaaagt agttaatctt aaacagagag
     1861 tttccgattg gtgagaggag caatagattt tactttgaac acatctttga gcaggactct
     1921 gaaagagtag aaatacttta ttaggagatt tccggaatcc ttgcacccgt tatagtgcta
     1981 gagtataata attttattgt acttaaagag gttagtgccg tgaggcatta atgaacagag
     2041 gtggaaccac gagagttaac tcccgtcctc tagcagaagc tagaggcggg agttttttaa
     2101 tataattttt taagcgcgca gagaattata ttgcaataga tacacttttt aaaaaataat
     2161 caaaatattt taaaaattaa aagacgaggg agaatattat gaaaaatata ttaaaaaaag
     2221 taggaatatt tacaattatg ttaggtttat taggtggagt tgtaggttgt tcaaaaccag
     2281 ataatgaaaa agataaggat gcttcaaagg aatctaaaaa agaagtagtt gtagggtttg
     2341 ataatacgtt tgtaccaatg ggatttttag atgaaaaggg agatacagta ggctttgacg
     2401 tagacttagc taaagaaaca tttaaaagac ttggaatgga agttaagttt cagcctatag
     2461 attggtcaat gaaggaaact gaattaaatg attcaaaaac tgtagatgta ttatggaatg
     2521 gatattctat aacagacgaa agaaagaaaa tagtatcata tacagaacca tatttacaaa
     2581 ataaacagat aatagttact ctaagtgact caaaaataaa ttcaaaagct gatttaaaag
     2641 ataaagaagt tggaacacaa caaggttcaa cagcacttga tgcagtggaa aaggataaag
     2701 attttatgaa tagcttaaaa ggtggagcac cagttcttta tgatacttat gataaagcac
     2761 ttagagattt agagataggt agaactagtg cagttgttgg tgatgaagtt ttaattagat
     2821 actatatggg acaaaagggt gaagacaaat acaaggtatt aaaagacgat tttggattag
     2881 aagattatgt tgtagcaact tctaaagaaa atccagaact ttgtgagaaa ataaatgaaa
     2941 cattaaaaga aatgaaaaaa gatggaactt ttgacaagat ttatgataag tggtttaaat
     3001 agaagataag ttagctgtta agaagggggc actaaaggca tgttacaagg tttagagata
     3061 gttatagcaa tgttttgtat aacattgata gtatcaattc cattggggat tggagttgca
     3121 tttttaagat tatcaaagaa taaattagta agtggtatta cacaatgtta tatattgata
     3181 atgagaggta cacctttact tttgcaaatg atagtcatat tttacggatt acctctttta
     3241 ggaattgtat ttgacagatt tacagctgga gtagtagctt tcttcttaaa ttatgcagca
     3301 tattttgcag aaatatttag aggtggaata cagtcaatcg atagaggaca atatgaagct
     3361 tcaaaagtac taggatttga taagtttact atgtataaga gagtaatctt tccacaagtt
     3421 tttaaaagaa tactagcacc tatttcaaat gaagtaatca cattagtaaa agatacatct
     3481 ttagtatata tattaggatt aaatgatatt ttaagaatat ctcaaatagc aatgaacagg
     3541 gaagcaagtc tgttaccatt atttgaggca ggagcgatat atcttatatt tgtagctata
     3601 cttactaagg gatttgaatt acttgaaaaa aaatattctt attatagata aagttacaat
     3661 attataggag gaggtttttt atatgttgaa aatcaaaaac ttaaataaat catttaaaaa
     3721 aaatagagta cttaaagata tttcttttga gttagaagaa ggtcagattg gagttttact
     3781 tggtaagtct ggtgcaggaa agaccacaat attaaggtgt ataaatggtc ttgaagaatt
     3841 tgatagtgga gagattataa tagataatga ggtaataaaa aataagagag atatggcaaa
     3901 aatacgagga aaaataggta tggtttttca aaatttcaac ttatttcctc atatgacagt
     3961 ccttgaaaat ataattgaat ccccagttaa tgtttttaaa gttcctagaa aagaggctga
     4021 agagagggct agagaacttt taagattagt tgatttagaa gataaattaa attcttatcc
     4081 atttgaattg tcaggaggac agcaacagag agttgctata gctaggtcat gtgcattgat
     4141 gccaaaagtc ctttgttttg atgaacctac ttctgcactt gatattgata ctattcaaag
     4201 agtagtcaat ataatgaaca gacttaaaga caaaggtatg acaatattaa taattacaca
     4261 tgatgttgtc ttctcaaata atgttgcaga taaaattata agtataaaag atggtatagt
     4321 agaaaatgtt caaataaaag aaaaaattgt ttagagtttt ataaatataa actagggtag
     4381 aattttataa tataaataaa gggcaagtaa aatcaaatat actatgccct tttgttatct
     4441 caaaatttaa tcttatattt tatgtttaag ttacattata atttataata aaaataaaag
     4501 gactatttaa atatataatg tgaataaatg tttaataatt tgaaatatga taatttttta
     4561 tgttgaaagc ttataatgat tatgatataa attggttata gtatacaatt tatgggtata
     4621 acaataaaaa attagaaagg aatttttata aaatgattaa attatatgga tatacaaaat
     4681 gctctactgt taaaaaagct aaaaattggc ttaaggaaaa taatttagaa tttgaagata
     4741 tagatatggt tcaaaaccct cctagtaaag aggagttaaa atcaatttat aagactagtg
     4801 gatatgatat aaagaaattt tttaatacaa gtggtatgaa atatagagaa ttgggtctta
     4861 aagatattgt aaaaactgaa tctgatgata aacttttaga aatattggta agtgatggta
     4921 tgcttattaa aagaccatta cttttggatg gtaaaaatgt attattgggc tttaaagaag
     4981 atgtatggaa aagtactttg ctaaaagaag attaggaaga gataggtgtg ttgattaaaa
     5041 ttattaatta atacacctat aaatttatgt attaaatcta atttttataa atattaatta
     5101 gcaaattcaa atcaaaaaaa ttcatatcaa caaacatatt acttcttatt acaaattata
     5161 tcatatgttt tatattaaaa tattataata ttacaacgaa ttgttacaaa attacttatt
     5221 attaaccatg aacatttgtt ttgtgctatc atatttatat aagggaattg tcataaaaaa
     5281 tatcttgttc atacagtttt atatagaaaa aagaaatgaa tcttttcttt atataagtat
     5341 attttgtaaa ttgcctctat atttatagtt taaataatag tggtattaaa aatctgacaa
     5401 caaaaataaa actttcaaaa aattaaatct aaaaagaata ggagataaat atgagtattg
     5461 aagatttata tgattttgaa tgtgttcctt tgaacaatga gattgatatt gatgttttat
     5521 ttgaaaagat gatagaagat ggaaaagaaa aagaatatac accaattata gtcattgatg
     5581 aaaaagtagg gctattaaga aaaaatatag atatgattac taaagagtat ggttctcttg
     5641 aaaactatag agagtattgt ttaacaaaat ataatgaaat tgatgtaaat caattttttg
     5701 attttaggaa gagtgagatt tcagaattat taaaggagct aattgattta gaagatgatt
     5761 tttatgatta taaacatttt agaccaatta tgaatataga tatatttcat gaatataaca
     5821 aagtttacat agctaaaatt ccaacaatta aaccatatga agtatttgca tacataccta
     5881 ttggcggatt taatgattgt cctagagatg aagaacatat agctattgca aaatattggt
     5941 atgaaaagca tggaatcttt ccaatcgcaa ttggatgtga tacagttcaa tattctgtaa
     6001 aaaatttaac taaagatggt aaaaaatttg atgaattatg tattgaatta gtattttatt
     6061 gtgaggatat tattatacaa gggtatgaaa ccttaaaggc tcttaaggat gtattaaaac
     6121 gctctacaat agtgcttttt tggtgggatt gatattccat catttagata gtattaaatt
     6181 gttagtcacc aagaatccac ttgctttagt tatggggagt gtgtcaaact aggtttttat
     6241 acacagtgta gcatagtaat atgtttaaat tacaaaggtt aaaaaaatac tttaatattt
     6301 ttaatattat aattaataga tttaaaggta attataattt ataaaataaa tactttatat
     6361 gttataatca ttaagaatgt aaaaaaataa tatatagttt tatagttcat atttttccag
     6421 atatggaggt aaattttgtg aaggaaaaag aaaaattaga taaattaaaa aaaatgttac
     6481 ttgaattagg cagtgttgta gttgcttatt ctggtggagt agatagtaat tttttgctta
     6541 aggtcgcaaa agatacatta ggtgaaaatg ttatagctgt gactattcat gcaatgatgc
     6601 attcaagtag ggaaattgaa gaggctaaac aatatactca aaattttggt gttaaacata
     6661 tcatattaaa tatagaaaac tttgatttaa aagaatttaa agaaaatggt gttgatagat
     6721 gttatcattg taaaaaatat atattctcta aaataaaaga ggtagcaaaa gaacataata
     6781 taaagtacat agtagatgga acaaatatag atgatttagg agactataga cctgggctta
     6841 aggcattgag tgaattagga gtaattagtc cattaaaaga tagtagttta aaaaaagaag
     6901 aaattaggtc gctttcaaaa acattaggat taaatacttt taataaacca tcatttgcat
     6961 gtcttgcgag taggatacct tatggagttg aaataacaga tgaaaattta agaatagtag
     7021 aaaagagtga agaatatcta tccaatttag gtttttctca atttagagtg agaatgcatg
     7081 gagatatagc tagaatagaa gttggacagg aagaactagg taaatttttt gaaaataaca
     7141 attttaataa agttgatact aaattaaaaa tatttggctt taaatatgtt acactagata
     7201 tgtcaggata taaaatggga agtatgaatt taaatgtgta gattatttta aaaataaata
     7261 agttttatag ttaatataag gaaacaggag gttttatgaa aaattatacg ttaatatcgc
     7321 catgtttttt tggaatggaa aaaatgctgg ctagagagat tactaattta ggatatgaaa
     7381 taataaaaac agaagatgga agaataacat ataaaactga tgagtttgga atagcaaagt
     7441 caaacatgtg gttgagatgt gctgaaagag tacatcttaa aattgctgaa tttgaggcaa
     7501 aaagctttga tgaattattt gaaaatacaa aaagaataaa ctggtctaga tatatacctt
     7561 atggagctca atttcctata tcaaaagctt cctctataaa atcaaaatta tacagtacac
     7621 cagatgtaca agccatagta aaaaaggcta tagtagaaag cttaaagaaa agttatttgg
     7681 aggatggttt gcttaaagaa gataaggaga aataccctat ttttgtattt atacacaaag
     7741 ataaagtaac catttctata gatacaacag gagatgcttt gcataagaga ggatatagag
     7801 aaaaggcaaa taaagctcca ataagagaga ctttagctgc tgggcttatt tatttaactc
     7861 cctggaaagc aggtagagtt ttagtagacc ctatgtgtgg ttctggtact atattgattg
     7921 aagctgctat gattggtata aatatggcac ctggcttaaa tagagagttt atatcagaaa
     7981 agtggagaac tcttgataag aaaatatggt gggatgtaag aaaagatgct tttaataaga
     8041 tagataatga atctaaattt aagatttatg gatatgatat agatgaagaa tctatagata
     8101 tagctagaga aaatgctgaa atagcaggtg tagatgaata tatagagttt aatgtaggag
     8161 atgcaactca atttaaaagt gaagatgagt ttggatttat aatcactaat cctccttatg
     8221 gagaaagatt agaagataaa gacagtgtta aacagttgta taaggagctt ggttatgcat
     8281 ttagaaaatt aaaaaattgg tcgtattatt tgataacttc ttatgaagac tttgaatatg
     8341 agtttgggca aaaagcagat aaaaaaagaa aattgtataa tggtatgtta aaaactaact
     8401 ttttccaata tccgggtcct aagcctccta gaaataataa ataagtttta catgatttat
     8461 ttgtaaaata taaaatttta ttaaaataag taaaacatta tgatgccttg aaacgtctaa
     8521 ttattgtgag gagatttttg tgaacaaatt taaagattta taggattagg aggagttaaa
     8581 tgaaagtgtt aaagcttatt actgtagtag ccctgatgat gttatttgtt actggatgta
     8641 atataaaaac tgaatctcca gaacaattag cgaagatacc tgactatgat gatacaaaaa
     8701 aagtattgta tgatggtatt gaccagttac taaaaccaga ttcatctatg atattgcctt
     8761 ctaatacaaa agaagtagga aaaataaata aggtagattt aaacagcgat ggaattgatg
     8821 aattagtagt atttgaacaa aaagaagatt taagtaataa tgtgagtcag gtagggtttg
     8881 taaccttgag ttacaatgga gaaaaatacg tacttggaga ccatttttta gaaaatggcg
     8941 aatcaataga atatgctaat ttttatgatt tggactcaga tggatataag gaagttatct
     9001 tattggttaa atccaaagac aaaacgaata tgcatatata taaagtagta gataatgaaa
     9061 taacaaaaat atatgacttg gatgcatcat ggcttcaaaa taaagaagat tttaatgata
     9121 tgaaagtaaa aattggatat atagatggag atgacaagtt agacatattg atgcttcatt
     9181 tgaataataa gactaatgaa atgtttgcaa gtgttgcaaa ttttgatggg aaaatgaaaa
     9241 tcaaagattc tgttaagttt gaaaatgtaa aaaacttaag tgaattatat ataacattag
     9301 gtaatgttgc ttcatctgtt ggaaattctt ctgcagctat aaaaggtatt gtacttgata
     9361 ttcctatatt gaaagataat aactatatta cgcagatact ttatatgaaa gatgggaaaa
     9421 ttaacaaagc ttttagtgat tatgataaaa ctattactaa atcttattat atacctgtag
     9481 atgatattga caaagataag attatagaaa tacctatagt tgcaggcagt acaggtaata
     9541 ataaaaatac ttatagttct aaatcatctg caactataag ttggtataga tggaatggaa
     9601 aagaaggtga tgactcaagt ttaatattta caagtcagat atattataat tataaatata
     9661 attttaaatt atttattcca aataatttat ttgataaaat acttgttgaa caggaatttg
     9721 ttggagaaaa agcagtattt aaattttact attttgacta ttcagaccgt aagaatttat
     9781 ttaatatagt agtagagagt aaaaataaac ttgaagatag aaaaaataca ggtactcaaa
     9841 attctattgt acttcaagag agcgatgaat atactttctt actagttgta aacaatgcaa
     9901 atgaaatgga taagctagat atgactatag acgcattaaa agaatatttc tcattaatat
     9961 atggttaata ttatactcaa ttggaggttt tattttatga aggaaaagat acttatacta
    10021 gaagatgaaa ttggtattag aagttttgtt agtataaact taaaaaggga aggctatgaa
    10081 atagttgagg caggtactgg aagagaagct atagaaaaaa tgacaacaga aaaggatatt
    10141 acaatagctc ttttagatgt aatgcttcca gatataagtg gtatagaagt atgtaaattt
    10201 ataagggaga attttgacca agtaggtata ataatgctta ctgctaaagc tcaagaagat
    10261 gataaaatag aaggatttat ctcaggagca gatgattaca tcataaaacc atttagtata
    10321 aaagagcttt tagtcagagt ttctgctctt cttagaagag tagcaaagga tgattcaagt
    10381 gttaagtcga gtgagatagt ttctccacca tttatacttg atatagacaa aagaaaatta
    10441 tttaaaaatg gaaaggaaat tgagcttaca ccaactgaat tttcaatagt gaaatatcta
    10501 atatcaaatg ctaagcagtc gttaagtaga gaccagatat tagacgaagt atggggaact
    10561 aactatttat atgattttaa aatagtagat gtaaatataa gaaggataag aaataaaata
    10621 gaagatgacc catcaaaacc aaaatatata caaactattt ggggttatgg atactgtttt
    10681 agaaaggaag aataatagtg ttacattttg aaggtctgag aaaaaaagta ataaaaaact
    10741 attttataat aattattata atggttactc tgtttgaagg attgttcatg ttttacatac
    10801 aaaactacta ttatgattct gtcaaacagc tacttgaatc tgaaataaaa tatgctgatg
    10861 aatataatgc tattacaatg gaaactacaa gttttgagaa aaaagtaaaa aatatatttg
    10921 ataaacaacc cttaactaaa aattcagaat ttggaatttc aataatagat aaagataaaa
    10981 atattatatt agaccaatat ggttttaaaa gtaaagaaaa agcaaactat gaagatgtta
    11041 acaatgcatt aaaagatata aaaactaaaa atttaacacc ttatacttat agaataccag
    11101 atacagggga gcatgttatg agtatctcct taccacttaa ggtaaataat ataatagaag
    11161 gtgttgttag atatacagta tcattagatg ctattgataa tgcaatatta aagcaagcta
    11221 catggcttat attagcagga atatttatac ttattatagc tatactaata agtcttaaat
    11281 ttgctgagac tcttataaaa ccattacgag agctaaagaa atttgcaaat gaattggctg
    11341 taggaaatta taatataaaa ttagaaaaga tgaagattgt agatgatgaa attggtgatt
    11401 tagcacagac atttgaacac atggcacatg agattgacaa aagtgaaaaa ttaaaagagg
    11461 aatttatatc atctgtatct catgaactaa ggactcctct tacatctata aaggggtgga
    11521 gtgaaacctt aggttatgaa agtataacaa gagaagaact agacttaggt ttaggcatta
    11581 tacaagatga aacagaaaga cttataaaac tagttgaaga attattagac ttttcaaggc
    11641 tttcttcaga caggataaaa cttcatgttg atatagttga tgttgaaggt ttaattgtag
    11701 gtgttgtaaa tcaacttaaa gttaaagcag ctgaaaaaga tatatcactt ttatttgaat
    11761 ttgaaaatga atttatagag aacattcaag gagataaaaa tagattaaga caggttctca
    11821 taaatttaat acaaaattca tttaaattta cgagtcaagg tggttacata aaagttgtag
    11881 cttctcaaga tgaagagata acaaccatat cagtagagga taatggttca ggtatagaaa
    11941 agcaaaattt aaataaagtg ttagataaat ttttccaaga agattataat aaggctggta
    12001 gtggattagg actagcaatt agtaatgaaa ttgtaaaact tcatggtgga agaatgaaaa
    12061 tagaaagtga aaagaatgtt ggaacaaaaa taacttttaa tataaaaaat aaatttgcta
    12121 aacaagcata aattcttaga aagaggatta agatgagaaa cataaaaatg atagtagcat
    12181 acgatggttc aagatataaa ggatatcaaa aattaggtga caataatatg actattcaag
    12241 aaaaacttga aaatgtttta agtaaaatga ctaatgaaac agtggagata ataggttctg
    12301 gaagaactga tatgggagct catgcaagag gacaagtggt aaattttaga actaattgta
    12361 tggattcttt ggataaaatt caaaaatatt tatatgaata tttaccagaa gatatagttg
    12421 taaaaactgt tgaagaagtt gatgaaagat ttcattcaag atacaatgta aaatcaaaaa
    12481 cttatatgta taaaattgac aataataagt atcatagtcc ttttataaga aaatatgcta
    12541 ctcatgtaag taaaaaatta gatttagata gaatgagaaa agcaagtgag tatttagtag
    12601 gagaacatga ttttaccagt tttgcttctt ctaaatctaa gaaaaaatca aatgtaagag
    12661 aaatttattc tataaatata aaagaagatg ataatgttat agaaatatat gtagaaggaa
    12721 atggattttt gtataacatg gtaaggataa tagtaggtgc tttaatagat gttggtctaa
    12781 aaagaagagc tccacaagat attaagtata tgcttgaatc aaaagataga tgtcaatcat
    12841 cagatactgc accagctaaa ggactatgtc tttggaaagt aacatattaa tcaattatat
    12901 aaaactctct ttaaaataaa aataaaataa attatatagt tgacataaat ggaaaaataa
    12961 actattatat attttataag agagatataa aactttatat ttaaatcctg tgagaaagag
    13021 agtaacttct atgtgtttta tagagagctg aggatggtgg aagcttggca aataagtatt
    13081 agtgaaaaga actttggagg atactaattg aatttagtat gttagtaggt aatctcgcct
    13141 taagagaaag agtggataag tttatcttat caattagagt ggtaacgcgg atatatttcg
    13201 tctcttggtt tttccaagag gcgtttttta atatatttaa ttattagtgt ttatctggta
    13261 tgttgaacat ttactaattg attagctaag tttatcaata agagtggtac cgcggatatt
    13321 tcgcctctta gtattttaaa atactaaggg gtttttttag tattaaaatg attttatgtg
    13381 agtctaaatt ctcagagtca ttcaatatta agaatttcta taaaataaaa attataattt
    13441 aagattggga ggaattaaaa atgaaggaaa aagtagtatt agcatattca ggaggacttg
    13501 acacatcaat cataatacct tggttaaagg aaaattatga agatatagat gttatagctg
    13561 tttgtggaaa tgtaggtcag gaagataaaa tggaagatgt atatgaaaaa gctttacaaa
    13621 gtggagcatc aaaggcatat gtggatgata taagtgaaga atttgtaact gaaactatat
    13681 ttaaagccgt aaaagcagag gctaaatatg aaggaaaata cttattagga acttctttag
    13741 caagacctat aatagctaaa aaattagttg aagttgctca taaagaaggt gcaaaatata
    13801 tatgccatgg atgtacagga aaaggtaatg accaagttag atttgaagct acaattgcag
    13861 ctcttgaccc gactataaaa gttattgcac cttggagaat ttgggatata aaatcaagag
    13921 aagatgctat agactatgct gaaaaacata atataaaggt aacagcaact aaagctaaaa
    13981 tatattcagt agatgctaac ctttggcatg tttcaacaga aggtggagat atagagcacc
    14041 tagaaaatga acataaaaaa gatgtttata aacaatgtgt agacccagaa gatgcatgtg
    14101 atgtagctga atatgtagaa gtttactttg aaaaaggtgt acctaaaaag gtaaatggtg
    14161 aagaattatc tccagttgca ctgattcata agttaaatga gttgggttgt aaacatggaa
    14221 ttggtgttat agatatagtt gagaatagac ttgttggtat gaaatcaaga ggtatatatg
    14281 agactccagg aggaacaatc ctttatgaag cacataatat tttagaaagt gctactttag
    14341 acaaagatac attacatttc aaacaaatgg tatcttataa atacggagaa cttatttaca
    14401 atggactatg gtattgtaaa ttaagagaat ctatagatgc atttatggaa caaactcaag
    14461 ataatgttac aggaacagta aaagttaaac tttacaaagg aaatataaaa cctgctggaa
    14521 tatttactga aaatgctctt tatgatgaag gaatatcttc ttttggaaat agtgaacttt
    14581 atgaccacaa agatgcagaa ggatttatta atttattcac tttaccatta aaaatcagag
    14641 ctatgaaagc tggaaaataa taaaataaat tatttaagag tgtataaaaa ctatttttag
    14701 gtttttatat gctctttttt tatttgaatt tattaactta tacagtaaat agtataaaaa
    14761 aatatattat agttccaaat ggcttaataa tgtgaaaata taagacctaa aatataaatt
    14821 ttataaatac aatagttatt gactctctca ttgtaagagg gtttatactg aatctaatga
    14881 aaatttatag tgaggagata gattatatga gaaaaataat tgaaattaaa catcattcac
    14941 atgattatga gtgtatgtgg aatggtatag aagatttata tataaataaa accggtgaat
    15001 gccttccaaa cgattttttc tttttactgt caggttttgg ttcattttgt tatatgaaaa
    15061 caaataaagc tgatttgaaa agaatggtag ctttgggaga tggaaggaca aaacagatgt
    15121 ataaattttt agcaccaatt gttggatttg aatacaaaca tcatgagttt aaaaagtatg
    15181 agcaagcatt aaagaaagca aaatctgaaa ttgatgatgg atatccagtt attttaggag
    15241 ctttagatat gtattatcta ccatattata agaagctata tcataaagaa catattcctt
    15301 ttcattatat attaatggta ggatatgatg atgaaggaat atatctgtat gattgtggta
    15361 gaacagaatt attacatctt tcttatgata aattacgtga aagcatgaat tgcaattccc
    15421 ctggattaag caaagaaaat actatttgca caataagaat gaatacttca aagaataaat
    15481 ataacattgc tagagaagct attgctataa agcgtgatat gtttttaaat ccacctaaag
    15541 gatttttggg atataaaggt tttgaaaagt ttattaaaga gttgccacag tggaacactg
    15601 aattggataa agatgattat gataagattt tgaccaatat ggttatgttt tttggaacag
    15661 taccaacaat tccaaatgca atcaaaggaa ttaaagaacc agatactgtt caatttaaag
    15721 gtggatttga taaaatgagt agaatgctca acagtattgg ggaggaatac aaaaacgact
    15781 cttttataca agtagctgat atttttgata aaactgctat tataattgag aaaatatcca
    15841 atattataat agattactta actcaaacat gtgatgatac aggacaactt ccgttattgt
    15901 tctctgaggt cttagagcat atgaaaacag gatatttaat cttggatgta taaaaaatat
    15961 attgttgacc ctaacattac gtaatagtgt aatatgaaaa tatagcttga atatattagt
    16021 aggtattgat ggctgtaaaa ttaaaatttg aggtgtggat atgagaacag tgaaacaagt
    16081 ttctgattta actggaataa gtgtgagggc attacattat tatgatgaaa taggtctttt
    16141 aaaaccaaat aaaattacag atgcaggata tagactttat gatgatgaat ctattaaaac
    16201 tcttcaacaa attttatttt ttaaggagat tgatattcct ttaagagagg ttaaggaaat
    16261 aatgtcaagc caatattttg ataaggttga agctctaaaa aatcaaaaaa aattacttat
    16321 tttaaaacga aagagactgg atgaattgat agagcttata aatcaaactc taagaggaga
    16381 aggaaatatt gattttaaag agtttgatat gagcgagtat tttgatgttt tagaagaatt
    16441 taaaagagag cataggaata aggtaattaa aatttatggt agtgtagaaa aatacaatga
    16501 atatatagaa agagttaagt ctaatgaaga gaaaattgct aaaatggcta taaaacaata
    16561 tggaactatt gagaagtttg ctaaagctat aaaaacaaat tttagcagtg atatattgaa
    16621 tttaggagaa aaatttgata gatataaaaa tgattgttta aaagaaaaac atccaaaatt
    16681 aaaagaatta tatagaaagc ttgtagaaga tttaaatagg aatccttctt caacagacct
    16741 tcaagaaata gcaaaagaga taacagatat atctaaaaaa gattatgaaa ttttctctat
    16801 ggatactggt gatgacaact ggtattatat ggttcaaaat tatctagtaa atcctatgtg
    16861 gatagaagaa gtagataaaa agtatggaag tggagcaggt aagtttattg gacaagtact
    16921 aaagacttat ctaagagata gaaaaccaaa gataaataca ttgtatgaaa aacttgtaga
    16981 agatttgagt agagattgtt cttcaaggga agttcaaagc attgttgaag aaatagacaa
    17041 tgaaatgaaa agaagtaatg aattttataa aatagacaat ggtgaaagat actttgatta
    17101 tatgtcagag ctttatttac aagattctaa ctatataaaa gtaactgata agaattatgg
    17161 tgatggtgca tctaagttta ttggagaagc ttttaagatt tattttgata ataataattg
    17221 ttgaaaattt ggaagtaaaa aatatgcaag ttttataaaa gcacaaaaat aaggatgtag
    17281 attagctcca tctatatcct tatttaaagt tattaaaata tatagtttac atcaaactta
    17341 acactttcaa taatatttcc caaatatgtt tttatacttt caacttcttc taaagatttt
    17401 aatttatttt cagtataaat tgctttgtcc agaatattaa accttaatcc tatttcatca
    17461 aagtactcat gatttaaaac tttgtaccaa tggttttttt ctttattcca actcgtagat
    17521 attgaatcag cttctttttg agctttttcc caatcttcat tttctataga tttttctaaa
    17581 acagatatat tgtctttata tccttctgta aaatcatata gtttattgtt aacataaaat
    17641 ccaaataata caaataagat agtccatagt ataacaaatg ttgtagattt caatattaat
    17701 cacccttttt attttgaata aatattttgt cattttcatc taaaacacaa ataagaacat
    17761 ctttaaaagt ttctatgtga ttagatttta aaatacccat taaccagtta gtatcttttt
    17821 gagctatgtc tagattttta tttattattc taccatccag tataagtggg ataggtaaat
    17881 gattaaaagc tcttggagga gtactattgt agcttgatgc tggtacaaca cttagattac
    17941 catcagtctc caaaatagca tattgtacat cttttaggtt aaagtatcct tgaatcctaa
    18001 gttgttctaa taattcatct atactaattc tttctttttt aagctcttta tatacaattt
    18061 ttcctttatc tattaataca gaaggtttac ctgataaaaa tgaacttaat tttctacttt
    18121 ttaatgataa gaatgaaatt agagtctgca tgattacaag tccagatatt gctgcaacac
    18181 catttatgat tggtatatta ttattttcca ttgggacaga tgcaacttct gcaattaata
    18241 gtgttataac taaatcaaaa cagttcattt cagctatttc accttttccc atgactctaa
    18301 gtgcaattag cactgttatg tataatataa tacttcttat taatactact gtcatatcta
    18361 tcaattactc ctttaaaaaa tatttacact tagttagtat atcctatata aaaaatttaa
    18421 ttcaaagtat aaaaaacctt aaataattgg attcaactat ttaaggtttt tttgataatt
    18481 ttaatattaa attttttatg gattttctgt tacttttatt tattttaata acagattcaa
    18541 caaaactctt tttatctcct aattttaaga taaaatcagg atattcttca aattcattga
    18601 gttttattaa tttgaaagaa gaagatagat ttttaaagtt aataatttta gagttattca
    18661 ctaatacact tcttttttta aaataaattt cttttttact tatatttagt atagttaata
    18721 tttgtttaag atatattatt atatcttctg gagttctatc aaatttgagt tcaaaatttt
    18781 catcttcaaa gtagggaata taatataaag gtgttttgag agcaggtaat ttattatata
    18841 attcttcaag aatatcgata tttttagggg agttaaagaa aaagcattta catacattca
    18901 ttaaatccac agcatctgaa agtgagttat gtttaatatc tccttctaca gaaaaaattt
    18961 ttttcatatt cagtaaagat atttgcttag ataagattct attattgtat gtaatatgtt
    19021 gagatataaa aggttgaatg tcaatcatca tattaaataa ctctaagcat ttacctgtat
    19081 atttatatac tctaaatgaa gttagaaggc cagttatatc aaaatcaccc caattatata
    19141 ttgtaacatc atcaaattta caaaaccatt tataaaaatc atccataaca tataaaagat
    19201 taggagcatt attgatatct agttggttca atttggttaa atttttacat ttatttgaaa
    19261 gtattttatt gtattttggc ttaactaaag agtaataatt atctattgta ttaaattcgt
    19321 tatcaactaa aactccacca atagaaatta attccgcacc attatattct tttggtttat
    19381 ttttattatc atctagtata ttaaattcaa agtctataaa taacttgtat ttcataaatc
    19441 taaagcacat cctcaggtaa attatttatt gagcctaagc atcataagaa tcaatagata
    19501 taatgactct aaacatcaaa ggttcattac aacttttatt tatttcataa tttaattcaa
    19561 ataaatcttt taagatataa tttataagta ttctttccca acccattttt aaattaactt
    19621 tagagtctat taatatattt tctatctttt taaatatttc tatatttgct ggtattatac
    19681 tgagctcaat attactttta aacgggttag actgtaaatc tgttataagt atatttttta
    19741 attcctctgt aagttcagaa attaaactat cacctatgta tttttttatg atttcctctc
    19801 taatttcttt taaatttagc aatattagta cctgctactt acatagtagc ttttcctttc
    19861 cttttaatac tattattcat ttttgaatct tatttagata tattttaaga ttaaaagtct
    19921 ttagctatat aattttttac ccatttttaa cttatattaa catattacag gcttatatct
    19981 ccaccctgtt tacattgagg atggagtata ttgcctattt tgataaaaat gataggttgc
    20041 tatttgccta ttcctttttc tgataatttt tctaacatat ctttggtcat tttatctaaa
    20101 tcataactaa acttaaagtt ccattctttt actgcactac tactgtctag agagttaggc
    20161 caagaatcag ctatactttg tcttacaggg tctacatcat attctatcac aaaatcagga
    20221 atatattttt ttatagaatc agctatttcc tcaggagaaa agctcatagc agtaatatta
    20281 aaagcatttc tatggatgag tttatcagct ggagcttcga ttaaatccac tattgattga
    20341 agtgcatcag gcatatacat catatccatt tttgtacctt ctgctatgta agatttatat
    20401 ctcttatttt ttaatgcctc ataatatata tcaactgcat aatctgtagt tcctccacca
    20461 ggaggcgtaa cataagaaat aagacctgga aatctaacac ctctagtgtc tactccaaat
    20521 tttgagtgat aataatcaca tagtaattct ccagaaactt tagtcacacc atacatagta
    20581 ttaggtcttt gtaatgtatc ttgaggagtc atattttttg gagaattttc accaaaagca
    20641 gcaattgaac taggtgtaaa aaatttacaa tccaattctt tggctatttc aagaccattt
    20701 attaatccat tcatatttaa gttccaagct tctagaggtt tactttcagc aactgcagaa
    20761 agtaaagatg ctagatgaat tatagtatct acatcatatt tttttgcaat ttcaaaaaaa
    20821 cgattcttat ctgtaacatc taatatctca aatataccag attcacatac tggattacct
    20881 tcttttactc tccttgaact agcgattaca ttttgttctc catactcatt tctaagcttt
    20941 attgttaatt ctgaacctat ttgtcctaat gcacctgtta taagtatttt tttcaatttt
    21001 acaacctcct aagggtttaa tttatgtagt actacttatt tttattttag caaatctttt
    21061 gtttaaatac aaagaattaa agataataat atacgactta attgaatgaa gtgcagtaag
    21121 tgcctaaaaa tttaaagcta atatataatg gtatattgta taacaataaa agagtagatt
    21181 aaattattat atatagattg tgtgactaag tcacagaaaa tagagttaat ttaatatata
    21241 ataaaagcat atcaagtaaa gctttaaatt aaagtaactt tataaataaa aagtaatata
    21301 aattgataaa attataaatt tatttatagt gaatatgggt tggattttat agatacaaaa
    21361 atagtatata tgatatgtag accattagca ggtttaaagt agcaaaacat ataaaataaa
    21421 atttgaaagg aagtataaaa atgacaagac catcaatata tcatagccaa ggatacactt
    21481 gtgcagaggc attaataaag tcttataatg aggaacataa cacagatata ccaatctcaa
    21541 taggaagtgg tatgggggtt ggaatgaatg ttggaagtgt ttgtggagct gtaaatgctg
    21601 ctgttgttat aatagggtat ttaaatgggc gaaatagtaa tttagatgaa aatatagcaa
    21661 ggaagtattc aagagagcta ttgaatagag taagaaataa atacagctca gaaatatgtg
    21721 tatctcttaa aaaaaataaa gtaacttgtg aagaaataat aaatttcaca tatgatgctc
    21781 taaatgatat gctaaaaaat caaaaataat tctaagaaac aagtatttta cattcgatag
    21841 aatacttgtt tttttatgat atttttaata agtattagtt tattataatt tttaaatcaa
    21901 ttttattata tttt
//
LOCUS       DAEHWM010000073        21632 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.074, whole genome shotgun sequence.
ACCESSION   DAEHWM010000073 DAEHWM010000000
VERSION     DAEHWM010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21632)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21632)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21632
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.074"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            55..1506
                     /locus_tag="KNP36_002659"
     CDS             55..1506
                     /locus_tag="KNP36_002659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine:cation symporter family protein"
                     /protein_id="HBF0874520.1"
                     /translation="MDFFNGILTSINNAVVYVNNYLWSYILIIMLVVIGIYFTIKTNF
                     VQFRYFIEMFRLLGDGTANKNAKKEGKISSFQAFCISTSSRVGTGNIAGIAIAVVAGG
                     PGAVFWMWLIALIGSASSFVESTLAQIYKVKDGQAFRGGPAYYMEQGLNKKWMGILFS
                     ILITICYGFVFNAVQANTVSLAFNNAFGISKMAMGIGLGILTAIVIFGGVHRVAKVSE
                     IIVPVFAGLYILVALAIVVMNITEIPSVIALIVESAFDFKGMAIGTFMGVVMTGVKRG
                     LFSNEAGMGSAPNAAATAHVTHPVKQGLIQSLGVFTDTIIICSCTAFMVLLYSGYSSS
                     GATGIELAQEALTHHIGPVGNIFIAVCIFLFAFSSIVGNYYYGESNMEFMSGSKTKLN
                     VFRVFVVGMVLFGSLTQVDVVWNLADLFMALMAIINLIAIALLGKYAFIALKDYTSQK
                     KSGIKDPVFIADEIEGLEKVSEWHRELSEEHLG"
     gene            complement(1725..2186)
                     /locus_tag="KNP36_002660"
     CDS             complement(1725..2186)
                     /locus_tag="KNP36_002660"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HBF0874521.1"
                     /translation="MIYEGKLIGKDLKIGIINSRFNEFITSKLLSGAEDCLLRHDVSP
                     ENIEIVWVPGAFEIPLVAQKMAKSGKYDAIICLGCVIRGATSHYDYVCSEVSKGIAKV
                     SLDSELPVIFGIVTTENIEQAIERAGTKAGNKGYDCAMNALEMANLFKSLN"
     gene            complement(2291..3484)
                     /locus_tag="KNP36_002661"
     CDS             complement(2291..3484)
                     /locus_tag="KNP36_002661"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HBF0874522.1"
                     /translation="MFNTIEEAIEDIKNGKMVIVVDDESRENEGDLLMAAEMATPESI
                     NFMATYGRGLICLPATEKKFKSLNIPLMVRENTDTFQTAFTVTIDGADTLTGISAYER
                     AETVKLFCDENSTSKDFKTPGHIFPLIAKTGGVLVRDGHTEASVDLARLAGFKEIGLI
                     CEIMKDDGTMARVDDLMIFKEKHNLKIITIKDLIEYRKINETTIEKVSSAFLPTKYGN
                     FEIIGYRDTYSNEEHIALTYGNINIENTLVRLHSECLTGDVFHSLKCDCGLQLESSMK
                     KIVENGSGVLIYMKQEGRGIGLLNKIKAYKLQEEGYDTVEANLMLGFEEDMRDFYMAA
                     QILKNLNIKSINLLSNNPDKINQLEKYGIKIENRIPINEEINDFNKLYLKTKKDKMGH
                     LLDII"
     gene            complement(3507..4172)
                     /locus_tag="KNP36_002662"
     CDS             complement(3507..4172)
                     /locus_tag="KNP36_002662"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HBF0874523.1"
                     /translation="MFTGIVEEVGILRKITANGKSGKVTILSNKILDGTNLGDSIAVN
                     GVCLTVSNLGKNEFTADVMMETIRSTNLGLLNANDKVNLERAMSLSSRFGGHIVTGHV
                     DGKGTICKFEKDENAVLVSIRPDKKLLSSMILKGSVAIDGVSLTISYLDDEIFKVSII
                     PHTKINTILLTKNVGDFVNLESDVIGKYVNNFMANNYKELNSNSNNHKSNIDKDFLFK
                     NGF"
     gene            complement(4206..5318)
                     /gene="ribD"
                     /locus_tag="KNP36_002663"
     CDS             complement(4206..5318)
                     /gene="ribD"
                     /locus_tag="KNP36_002663"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HBF0874524.1"
                     /translation="MNFVNQKEKDIYYMKKAIELAKNGEGFVNPNPLVGCVIVKASNI
                     IGKGYHEKFGSNHAEVNAINSAKQSLKDSTLYVNLEPCSHYGKTPPCVDKIIQNKIKR
                     VVISTLDPNPLVCGNGVKKLKDNNIDVTVGILEDEARDLNEAFFYHIKNKRPLCIVKS
                     AVSLDGKIATKSLESKWISNESSRYLTHKYRNKYQSIMVGINTVLNDNPLLTCRLNQE
                     KVSHPTRIVIDTHLKLPLNSNLVKDKTSKTIVFTCCKESIKLSMLKENNVETIISPSK
                     NNLVDLEFVMYKLGELNIDSVLVEGGATLNDSLFRNKLVDKVKLFLSPKIIGGKDAPT
                     FVSGEGINHLSDSTQLTINNVTLIDGDILIESDVLN"
     regulatory      complement(5450..5571)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            5760..8243
                     /gene="recQ"
                     /locus_tag="KNP36_002664"
     CDS             5760..8243
                     /gene="recQ"
                     /locus_tag="KNP36_002664"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase RecQ"
                     /protein_id="HBF0874525.1"
                     /translation="MNKKLLEILSKYYGYTSFRKGQESIINSILSEKDVLAIMPTGGG
                     KSICYQIPALILDGMTIVISPLISLMKDQVDALKTMGISAAFINSSLSSKEFNEILNN
                     IRKNNYKILYIAPERLDAQEFIELINNNNVSQVAIDEAHCVSQWGHDFRLSYRRISDF
                     IKNLPKRPIVTAFTATASEEVRTDIINLLCLENPDYYITGFDRENLSINIVKSSSKNK
                     YILDYIQNHKNESGIIYVATRKEVENIYNGLSKRNISVSKYHAGLSKNERSKNQEDFI
                     NDNVDIMVATNAFGMGIDKPNIRWVIHYNMPQSIENYYQEIGRAGRDGEKSECVLLFS
                     PGDVHIQKYLIDIGVENPERKLFQHKKLQYMIDLVYSNSCYRKTILSYFGENYIDNCN
                     NCSNCLVEGEIVDKTIDAQKVISCVARMKRSYGVTTIVDVLRGSKNKKILQLGLNTLS
                     TYNIMRDYSSEDLKNFVNTLVSHGFLDLVETLGNGNRGSFPTIRLNEMSMKVLKGEVK
                     VEFKEIVMTKSLEVEDELYNALRELRHSIASEERIAPYMVFGDGTLRAMSSSYPINKE
                     EMLDISGVGEIKYQKYGRDFEAVIKEYVEKNNINKKIDEKNVDSKNVNSDFLEVNTDK
                     VLYEKLLVIREEYATKEKLPAYMILANKALKEISGRYPLDEEQLKDISGIGGVKFEKY
                     GASILAEVNKYVKENNINVIWEKKGKRKLILDGESRKNNEIALDLLNQGKDIQSISQE
                     IEVSLSTIIGYVHDYVKDGHSISFELGLENFYNEDKKKMILEVCEKVGYDNLNNIKRK
                     LPDSIKYENIRAVILDSYLENLKNNIIAE"
     regulatory      8332..8443
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            8585..9886
                     /gene="thiC"
                     /locus_tag="KNP36_002665"
     CDS             8585..9886
                     /gene="thiC"
                     /locus_tag="KNP36_002665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomethylpyrimidine synthase ThiC"
                     /protein_id="HBF0874526.1"
                     /translation="MNYTTQMDAARKGIITKEMEIVSQKEQVDVNELRELIANGQVVI
                     PANKNHKSLSAEGVGKNLRTKINVNLGISRDCKDIEKELEKVRVAIDMKAEAIMDLSN
                     YGKTREFREKVVEMSPAMIGSVPMYDAVGYLEKELKDITEEEFLNVIRQHAIDGVDFI
                     TIHAGLTRSVCQKIKNHERLTHIVSRGGSLLFAWMELNNKENPIYTNFDKILDICEEY
                     DVTLSLGDACRPGCIKDSTDGVQIQELVVLGELTKRAWERNVQVMIEGPGHMAIDEIE
                     ANVVLEKRLCHGAPFYVLGPLVTDIAPGYDHITSAIGGALACAKGVDFLCYVTPAEHL
                     RLPNLDDMKEGIIAAKIAAHAGDIAKNVKGAREWDNKMSKARADLDWCEMFRLAIDPE
                     KAKRYRDESTPTHEDSCTMCGKMCSMRTVKKILNNEELNLI"
     gene            9940..10134
                     /gene="thiS"
                     /locus_tag="KNP36_002666"
     CDS             9940..10134
                     /gene="thiS"
                     /locus_tag="KNP36_002666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfur carrier protein ThiS"
                     /protein_id="HBF0874527.1"
                     /translation="MKVNGKEIEFEKDLTVIDLLNKYNLKSDRVVVEVNLEIIEESNY
                     NTYVLKDEDIVELISFIGGG"
     gene            10127..10930
                     /gene="thiF"
                     /locus_tag="KNP36_002667"
     CDS             10127..10930
                     /gene="thiF"
                     /locus_tag="KNP36_002667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine biosynthesis protein ThiF"
                     /protein_id="HBF0874528.1"
                     /translation="MVKIKIFVNELLTDVEENTTAYKVRDSYNNKCDVLVLNGYPIKT
                     DMTLCENDKLTLIQKGVKPSLDELESLLIARHTPNIHNKLKKGKVAILGLGGLGSNIA
                     ISLARIGVGELLLIDYDVVEPSNLNRQQYFIDDIGKLKTDAMIENIKKINPFIKLNKR
                     DIFLNKNNMDTIKDSDLIIEAFDDASCKAQVCNYVLINLKDKYLIASSGMAGYYDSNI
                     ITTKKIKDRFYICGDFVNEAKFGEGLMAPRVAICANHMANLATQILIDM"
     gene            10993..11763
                     /locus_tag="KNP36_002668"
     CDS             10993..11763
                     /locus_tag="KNP36_002668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018592874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiazole synthase"
                     /protein_id="HBF0874529.1"
                     /translation="MDKLVLGGHEFNSRLLVGTGKYGSNNILPEVIKESGSEIITMAL
                     RRVDLDNKQENILTYIPKEMTILPNTSGATNAEEAVRIARISRKMGCGDFIKIEVISD
                     TRYLLPDNEETIKATKILADEGFIVLPYMTPDLYAGRRLIEANAAAVMPLGAPIGSNR
                     GLQMKEMIRIMIDELDIPIIVDAGIGKPSQAMEAMEMGADAVLVNTAIASAGDPVQMA
                     RAFKLAVEGGREAYIAKTGNVSEFANASSPLTGFLGNL"
     gene            11780..12883
                     /gene="thiH"
                     /locus_tag="KNP36_002669"
     CDS             11780..12883
                     /gene="thiH"
                     /locus_tag="KNP36_002669"
                     /EC_number="4.1.99.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-iminoacetate synthase ThiH"
                     /protein_id="HBF0874530.1"
                     /translation="MSFYDVIEKYRDFDFDGYLNNVTDNDVLRSLSKDKLEDFDILNL
                     LSKTAVKHLEDMAQKAHKLSVQYFGKTVCLYTPMYIANYCVNQCVYCSYNIKSGIKRK
                     KLTMDEIREEGEVISKEGFKHLLVLTGESSFHSSVEYIGEAIEILREKFPSIGIEVYP
                     MEVEEYKYIVDKGVEGLTVYQETYDEEIYKRVHIKGPKSNYKFRLDAPERGAKAGMRT
                     LSIGALLGLNDFRKETFFTILHGKYLKTKYPHIELSYSTPRMRPFKGCFEELVDISDT
                     DLVQAMVCMRLFDPHAAINISTRENLEMRSHIIPLGVTKLSAGVSTDVGGHSQDEHDT
                     AQFKINDESTVKDVEKMLNSIGYQHVFKDWERF"
     gene            12884..13573
                     /locus_tag="KNP36_002670"
     CDS             12884..13573
                     /locus_tag="KNP36_002670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889638.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HBF0874531.1"
                     /translation="MYLITNRKLCSEERYLEVIKESILSGVENIIIREKDLEYQELRK
                     LYMKIKTKINCIDFQEQISDESLKTNINQKEFRNKFKVNFIINSNIEFFEKVDCQGIH
                     LPFKLFLNLIENKYNFNENKILGLSLHKVEEVDYLEKLIRNQNIKIDYITLSHIYETK
                     CKEGLNPKGIELLKEAKKITDIKIIALGGILPSNVKETLKYCDDFAIMSTIMRSKDIK
                     KTISNYNEKLN"
     gene            13761..15155
                     /gene="yfcC"
                     /locus_tag="KNP36_002671"
     CDS             13761..15155
                     /gene="yfcC"
                     /locus_tag="KNP36_002671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative basic amino acid antiporter YfcC"
                     /protein_id="HBF0874532.1"
                     /translation="MTDSKKKRFIIPHTFTIIFLLIVLMAILTWIVPSGEFSREDVEG
                     RMVVVPGTYQSVESNPQGFADVFKAPIEGFIDSAEVVGFVLIVGGAFGIVNRTGAIEA
                     GIASVISKFKGKELLIIPISMILFGLGGTTFGMAEETLPFYMIFVPLMTSLGYDSLTA
                     IAIVFIGAAAGAAASTINPFSVGIAQALAQLAPGSGVTYRVVIFIAYILISIAFVMYY
                     AKKVKENPESSIVYEIDKNNKSILNQTSTEIKEFTFKEVSVLAIFGIGMAIMIWGVLS
                     QGWYIPEISMCFAAIGVLSGLVGRLSQIEISESFIDGAKDLASAALAIALARGIVIIA
                     QNGFIIDTILNSAAAFLGGLPKVIFVYLSFFLEAALAFLIPSSSGLASLTVPVLAPLG
                     DLVNISAQVIVTAYQFGVGLTNFITPTSGVLMGALAVAHIPFSKWVRFIMPILLILTA
                     VSLVFLTIGIYIGF"
     gene            15672..17039
                     /locus_tag="KNP36_002672"
     CDS             15672..17039
                     /locus_tag="KNP36_002672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase"
                     /protein_id="HBF0874533.1"
                     /translation="MGLKEFDFIEESIDMLRTMSPTLETISDEIEEYFENILDEKNQE
                     YINVTSRIKSESSLREKIIRNRYLKKYGEASNLIHNVSDLIGLRIECRFIEDENKIYR
                     LLRRYFNKTDDKINYYNKENKNIKLKLSERQPNKQKNGFEIYKIDGVFAYLDREVKFE
                     LQIKSLVNVFWSEIEHKIIYKNNTYLLADKFIKDMMDSIKNNLTMIDNQLLSIYKNFH
                     SGKSFNMKVSKKEIEKLFAKLVYDAFSEKMNKSIGFVVDFKKPCETILNYSFNKQDIS
                     DEVLGNFMLDEFARLNEIVNKDIDFNEQIEFEREPTFDDKFCKDLGNHFRSRLNTEFP
                     WNLFFRILFEIEPYNNTKDFENFVEFIKENVLLEENREQLLCQFEEDSKLIIEDIYDC
                     IFNSISEIDSVEILYNYNLEKINFTSSEIINCICREYECYGEYLEEKEKLMNTFKEKI
                     IQIFE"
     gene            17064..17672
                     /locus_tag="KNP36_002673"
     CDS             17064..17672
                     /locus_tag="KNP36_002673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdenum cofactor guanylyltransferase"
                     /protein_id="HBF0874534.1"
                     /translation="MRHFSNIYELSKIILEEAICIEKTGVILAGGKNSRMGRDKAFLE
                     LHDKLFIEIAIEAFKNFDELIIISNNEELYSKYDIKVYNDIVKDVGPIGGIYTALEYA
                     KYDIVTIACDMPYLNNQIVERIANKMDDKSVISVTNGKLQPLCSGYKKSIINKVSLCI
                     RENDLKLRSFIDKIDKSYIYFDEEDLFLNVNTVDEYKKLTKV"
     gene            17720..18091
                     /locus_tag="KNP36_002674"
     CDS             17720..18091
                     /locus_tag="KNP36_002674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HBF0874535.1"
                     /translation="MNLLKCDSWAVILNNSDKESKAYKILDELKRNMYKVVAIDEEKK
                     PIEGIDVYECLKDVPHNIDVVAIIDKQSKMDVILEEVELLDIQNMWFEKGSFSEMMIK
                     KTKDLKLNIEYNLSLYDELTR"
     gene            18270..18608
                     /locus_tag="KNP36_002675"
     CDS             18270..18608
                     /locus_tag="KNP36_002675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal-binding domain-containing protein"
                     /protein_id="HBF0874536.1"
                     /translation="MLIVTTEKVEGKKISKVLGLVRGSTIRAKHVGKDIGASFKNLVG
                     GELTGYNEMLTEARQIAIGRMVEDAEAKGANAVIAFRLSSASVMQGAAEMLAYGTAVV
                     LEDDNSILEK"
     gene            19074..19577
                     /locus_tag="KNP36_002676"
     CDS             19074..19577
                     /locus_tag="KNP36_002676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MogA/MoaB family molybdenum cofactor
                     biosynthesis protein"
                     /protein_id="HBF0874537.1"
                     /translation="MFNVAIITLSDKGYEGKREDITGKKLTEFVENTGVYKVTEYVLI
                     KDDKEMLKENIIRLCNSNKIDLILTNGGTGFSKRDITPEATKEVLEKEIPGLSEYMRM
                     KSTEITKKAILSRGVSGIRNNSIIINLPGSPKGAVENLSFIIDVLDHGIEVLRGEATE
                     CATKKSE"
     gene            19624..20583
                     /gene="moaA"
                     /locus_tag="KNP36_002677"
     CDS             19624..20583
                     /gene="moaA"
                     /locus_tag="KNP36_002677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP 3',8-cyclase MoaA"
                     /protein_id="HBF0874538.1"
                     /translation="MIDKYGRKIDYLRISLTDKCNLRCVYCMPPDVKFDKNYINENLS
                     FEDYKFIIKAMAEQGITKIRFTGGEPLLYPKLNELIKFTKEECGINNIGMTTNAIGLS
                     DRIFELEKCGLNKVNISLDSLKEYKYKSITRGGNLKDVLKSIESCLNLGIKVKLNCVA
                     ISGFNDDELKDFMFLTVKSPIDVRFIELMPLGEANRVYKKGYFNVKEMIEKIYGLYKV
                     KNDEKSTAEYYMFKGAKGRIGIITPLSCSFCNTCNRIRLTSSGAIKLCLHSKEEIDIK
                     PFLHKPLLFRESMKDIIKQKPEKHHLIENKCSDTNRRMYEIGG"
     gene            20587..21057
                     /gene="moaC"
                     /locus_tag="KNP36_002678"
     CDS             20587..21057
                     /gene="moaC"
                     /locus_tag="KNP36_002678"
                     /EC_number="4.6.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic pyranopterin monophosphate synthase MoaC"
                     /protein_id="HBF0874539.1"
                     /translation="MLTHINEKGYAKMVDISEKDDTKRTAVATATITLSKEALEKVKN
                     GQIKKGDVLSVAQVAGIMGAKNTSSNIPMCHQIKLVGCDLEFDVDDSMSAIKIYATCK
                     SLGKTGVEMEALNACSLAALTIYDMCKAVDKKMVISNIHLVEKTGGKSGDFKFE"
     gene            21093..21524
                     /locus_tag="KNP36_002679"
     CDS             21093..21524
                     /locus_tag="KNP36_002679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MOSC domain-containing protein"
                     /protein_id="HBF0874540.1"
                     /translation="MAKVVSINISEKKGVIKVPVQCAELKINHGIVGDAHAGNWHRQI
                     SLLGKESIDKMKMKGFDQLKYGDFAENVTTEGIEVFSLPVGTKLRIGQCEVEVTQIGK
                     KCHNGCEIKKLTGDCVMPREGIFVKVLKEGIINVNDSIDVI"
BASE COUNT         8339 a         2337 c         3746 g         7210 t
ORIGIN      
        1 ttgattttaa gatttattga gaaaacaaaa ctaaataggg gggtaattaa tataatggat
       61 tttttcaatg gtattttaac gagtattaac aatgcagtag tatatgtaaa caattactta
      121 tggtcgtata tcttaattat aatgttagtt gtaattggta tttactttac tattaaaaca
      181 aattttgtac aattcagata ttttatagaa atgtttagac ttctgggtga tggtacagcg
      241 aataaaaatg caaaaaagga aggaaaaatc tcttcatttc aagcattttg tataagtaca
      301 tcttcaagag ttggaactgg aaatatagct ggaatagcaa ttgcagtggt agcaggagga
      361 cctggtgctg tattttggat gtggcttata gcattaattg gttctgcatc aagctttgtt
      421 gagagtacat tagctcagat ttacaaagtg aaagatggtc aagcttttag aggtggacca
      481 gcgtattata tggaacaagg tctaaataaa aaatggatgg gtattttatt ctcaatactt
      541 ataactatat gttatggttt tgtatttaat gcagttcaag caaatactgt ttcacttgca
      601 tttaataatg catttggaat aagtaaaatg gctatgggaa taggtcttgg aattttaact
      661 gcaatagtta tttttggtgg agtgcataga gttgcaaaag tttctgaaat aatagttcct
      721 gtatttgcag gattatatat attagttgct ttggctatag ttgtaatgaa tataacagag
      781 ataccaagtg ttatagcatt gatagttgaa agtgcatttg attttaaagg aatggcgatt
      841 ggtacattta tgggagttgt aatgactgga gtgaagagag gtctattttc taatgaagca
      901 ggtatgggta gtgctcctaa tgctgctgca acagcacatg taactcatcc tgtaaaacaa
      961 ggtttaattc aatctttagg tgtttttaca gatactataa taatatgtag ttgtacagca
     1021 ttcatggtat tattatattc aggttatagt agtagtggag caactggaat tgaattagct
     1081 caagaagctt taactcatca tataggacca gttggaaata tatttatagc agtttgtata
     1141 ttcttgtttg catttagttc tatagttggt aattactatt atggtgaatc aaatatggag
     1201 tttatgagtg gaagtaagac taaacttaat gtatttagag tttttgttgt aggtatggtt
     1261 ttatttggtt cacttactca agtggatgta gtttggaatc ttgcagactt atttatggca
     1321 ttgatggcga taataaactt aatagcaata gcacttttag gaaaatatgc atttattgct
     1381 ttaaaagatt atacaagtca aaaaaaatca ggaataaaag accctgtgtt tattgcagat
     1441 gaaatagaag gcctagaaaa ggtatcagag tggcataggg aattatctga ggaacattta
     1501 ggataaaaaa tagtataaaa ttataaaacc attttgaaag actagagtat gtatatactt
     1561 tatatgaata taatattgaa ttaatttata ttactggaat ttttaattcc agtaatattt
     1621 ttttattata taatttagct ttattaaaag tttttattat taaaaatagc ttatttatcg
     1681 taaagtgaat gatattgggt tttaattatt atgaatgtta gtatttaatt taaagactta
     1741 aataaatttg ccatttctag cgcattcata gcacaatcat aacctttatt tccagctttt
     1801 gtacctgctc tttcaatagc ttgttcaata ttttctgtag ttacgattcc aaatataaca
     1861 ggtaattcac tgtctaaaga tactttggct atccctttag agacttcact acatacataa
     1921 tcataatgag aagtagcccc tcttataaca cagcctaaac agattatagc atcatactta
     1981 ccacttttag ccattttttg agcaacaaga ggaatctcaa aagctccagg tacccaaact
     2041 atttctatat tttctggaga aacgtcatgt cttaaaagac agtcttcagc tcctgataaa
     2101 agttttgatg ttataaattc attaaaacga gaatttatta tacctatttt taaatctttt
     2161 ccaataagtt ttccttcata tatcattttt acttcctcca attttattta tgttatagat
     2221 ttatatttat aaatatcttt aatttaatta taaaaaacta cttagtagaa aaatatcatc
     2281 atataatcat ttatataata tctaaaagat gtcccatttt atctttttta gtttttaaat
     2341 atagcttatt aaagtcatta atttcttcat taatagggat tctattttcg atttttattc
     2401 catatttctc taattgattt attttatctg ggttattact taaaagattt atacttttta
     2461 tgtttaaatt ttttaatatt tgagcagcca tatagaaatc tctcatatct tcttcaaatc
     2521 caagcattaa atttgcttca acagtatcgt aaccttcttc ttgaagttta taagccttaa
     2581 ttttatttaa aagaccaata cctctacctt cttgcttcat ataaattaaa actccacttc
     2641 cattttccac aattttcttc atagaagatt ctagctgtaa tccacaatca cattttagag
     2701 agtggaacac atctcctgtt aaacattcag aatgaagtct aactagagta ttttctatat
     2761 ttatatttcc ataagtaagg gcaatgtgtt cttcatttga ataagtatct ctatatccta
     2821 tgatttcaaa atttccatat tttgtcggaa ggaaagcact agatactttt tctatagtag
     2881 tttcatttat tttgcggtat tctataaggt cttttatagt gatgattttt aaattatgct
     2941 tttctttgaa aatcattaaa tcatcaactc ttgccattgt accatcatct ttcattattt
     3001 cacagataag accaatctct ttaaaacctg caagtctagc aaggtctact gaggcttctg
     3061 tatgtccatc cctgacaaga accccaccag tttttgctat taaaggaaag atgtgaccag
     3121 gcgttttgaa atctttactt gtagaatttt catcacagaa taattttaca gtttcagctc
     3181 tttcatatgc agatatacca gttagagtat ctgctccatc tatagtaaca gtaaaggctg
     3241 tttgaaatgt atctgtattt tctctaacca taagaggtat attaagactt ttaaattttt
     3301 tttcagtggc aggtagacaa attagacctc taccatatgt agccataaaa tttattgatt
     3361 caggagtagc catttcagct gccatcaata aatctccttc attctctcta ctttcatcat
     3421 caaccacgat taccattttc ccatttttta tatcttcaat agcttcttca atagtattaa
     3481 acatgtaatt cactccttta ttatttttaa aaaccatttt taaataaaaa atctttatct
     3541 atatttgatt tatggttatt actattagaa tttaattcct tgtagttatt agccataaaa
     3601 ttattaacat actttccaat tacatcgctt tctaaattaa cgaaatctcc aacattcttt
     3661 gtcaagagaa tagtgttaat tttagtatga ggtataatag aaaccttaaa tatttcatca
     3721 tctaaatatg atatagttaa acttacacca tcaatagcaa cagaaccttt gagtatcatt
     3781 gaggataaaa gttttttatc aggtcgtata cttactaaaa ctgcattttc atctttttca
     3841 aatttgcaga tagttccttt accatcaaca tgacctgtta ctatatgacc accaaatctt
     3901 gaagaaagac tcatagctct ttcaagattt accttgtcat ttgcatttaa taaacctaaa
     3961 tttgtggaac gaattgtctc catcataaca tcggctgtaa attcattttt tccgaggttt
     4021 gaaacagtta gacaaactcc atttacggct atactatctc caagatttgt gccatctaat
     4081 attttatttg atagtatggt tacttttcca ctcttaccat tagcagtaat ttttctaagt
     4141 attccaactt cttctactat gccagtaaac atcctaacct cctatatgaa tgtattaaca
     4201 aaaatttaat ttaaaacatc tgattctata agaatatcgc catctatcaa agttacatta
     4261 ttgattgtta actgtgttga atctgacaaa tgatttattc cttctccaga aacgaatgta
     4321 ggtgcatctt taccacctat aatcttgggt gatagaaata atttgacctt atcaactaac
     4381 ttatttctaa agagactgtc attgagagta gcaccacctt caactagaac agaatcaatg
     4441 tttaactctc ctaatttata cattacaaac tccaaatcta ctaagttgtt ttttgaagga
     4501 gaaattattg tttcaacatt attttctttt aacatagata attttatact ttctttgcaa
     4561 catgtgaaaa ctatagtttt actggtttta tctttaacca aattactatt aagtggcaac
     4621 tttaggtgtg tatctattac tattcttgta ggatgagaca ctttttcttg attgagccta
     4681 caagttagta aaggattatc gttcaaaact gtatttatgc caaccattat actttggtat
     4741 ttatttctgt atttatgagt tagatacctt gatgattcat tagatatcca ttttgattct
     4801 agtgattttg tagcaatttt accatctaga cttactgctg attttacaat acaaagaggt
     4861 cttttgtttt ttatatgata aaaaaatgcc tcatttaaat ctcttgcttc atcttctaat
     4921 attcccacag taacatcaat attgttatct tttaattttt ttactccatt accacaaaca
     4981 agtggatttg ggtctaatgt agatattaca actctcttaa tcttattttg tataatttta
     5041 tctacacaag gaggcgtttt cccataatga gaacatggtt ctaagtttac ataaagagta
     5101 gagtctttta gactttgttt agcactgttt atagcattta cttcagcatg attagagcca
     5161 aatttctcat gatatccttt gcctattata ttactagctt taacaattac acacccaact
     5221 aatggatttg gatttacaaa gccttctcca tttttagcca attcaatagc ttttttcata
     5281 taataaatat ctttttcttt ttgattcaca aaattcacaa tatgtacacc tcctgtttaa
     5341 ttggataatt tttaaacaaa aaaccctgag aattaactca gggtttagaa taatctacaa
     5401 taaatgttta ataaatgtag aacaaaattg ctctacaaaa acactcatta aatatcttct
     5461 tccatccaga ctttactgtc ggctttggaa tttaaccaaa tcaaccaagt tttaccttgg
     5521 ctcgcgggct ataccgccga ttgggaattt caccctaccc cgaagattaa gtattaaatt
     5581 tatatttaga atgtatcata aattatttta ctttgcaaac tattttttta aaaaatatat
     5641 gttaatatat aatatagaat gtctataaac tttgaaatac cacgattgtg aatataaaaa
     5701 taaaaatttg aacataatca ggaaagaagt ctaattaatt taaattagga gagtaatata
     5761 tgaataaaaa acttttagaa atactatcaa aatactatgg atatacaagt tttagaaaag
     5821 gtcaagaatc tataataaac tctatcttaa gcgaaaaaga tgtgttagct attatgccaa
     5881 caggaggggg aaaatcaata tgttatcaaa ttccagcttt gattttagat ggaatgacaa
     5941 tagtaatttc tccacttata tcacttatga aagaccaagt agatgcctta aagactatgg
     6001 gaattagtgc tgcttttata aatagttcat taagtagcaa agaatttaat gaaatattaa
     6061 ataatattag aaaaaataat tataaaatac tctatattgc tccagagaga ttagatgcac
     6121 aagagtttat tgagctaata aataataaca atgtaagtca agttgcgata gatgaagcac
     6181 attgtgtatc tcaatggggg catgatttta ggttgagtta tagaaggatt tctgatttta
     6241 taaaaaattt gcctaaaaga cctatagtta cagcatttac tgcaacagct tcagaagagg
     6301 taagaactga tataataaat ttactgtgtt tagaaaatcc agattattat ataactggat
     6361 ttgatagaga gaatttatca ataaatatag taaaatcatc tagtaaaaat aagtatattt
     6421 tagattatat tcaaaatcat aaaaatgagt ctggaattat atatgttgca actagaaagg
     6481 aagttgaaaa tatatataat ggtttatcta agagaaatat atctgtgtca aaatatcatg
     6541 caggtttatc taaaaatgaa agaagtaaaa atcaagaaga ttttataaat gataatgtgg
     6601 atataatggt agcaacaaat gcatttggaa tgggtattga taaacctaat ataagatggg
     6661 ttatacatta caatatgcct caaagtatag aaaactacta tcaagaaata ggtagagctg
     6721 gtagggatgg agaaaaaagt gagtgtgtac ttttattttc tccaggagat gtacatatac
     6781 aaaaatattt aattgatatt ggagttgaaa atcctgaaag aaaattattt cagcataaga
     6841 agcttcaata catgattgac ttagtttaca gtaattcatg ctatagaaag acaatattga
     6901 gttattttgg agaaaattat atagacaatt gcaataattg tagcaattgt ttagtagagg
     6961 gtgaaatagt agataaaact atagatgcac aaaaagtcat ttcatgtgta gctagaatga
     7021 aaagaagtta tggtgttact actattgtag atgtgcttag aggttctaag aataaaaaga
     7081 ttttacagct tggattaaat actttgtcta catataacat tatgagagat tattctagtg
     7141 aagacttaaa gaattttgta aatacattgg tttctcatgg ttttttagat ttagttgaga
     7201 ctctaggcaa tggaaataga ggtagttttc ctactataag attaaatgag atgtctatga
     7261 aagttttaaa aggtgaagtg aaagtagagt ttaaagaaat tgttatgaca aaatcattgg
     7321 aagtagagga tgagttatat aatgctttaa gagaacttag acattcaatt gcaagtgaag
     7381 aaaggatagc tccatatatg gtatttggag atggtacact tagagccatg tctagtagtt
     7441 atccaattaa taaagaagaa atgctagata tctctggagt aggagaaatt aaatatcaaa
     7501 aatatggtag agattttgaa gcagtaatta aagaatatgt cgaaaaaaat aatataaata
     7561 aaaaaataga tgaaaaaaat gtcgattcaa agaacgttaa tagtgatttc ttagaggtta
     7621 atacagataa agttttatat gaaaaactgt tagtcattag agaagaatat gcaacaaagg
     7681 aaaaattacc tgcatatatg attttagcca ataaggcttt gaaagaaata agtggaagat
     7741 atccacttga tgaagaacaa ttaaaagata tttctggcat aggtggagta aaatttgaaa
     7801 aatatggagc tagtattttg gcagaggtta ataaatatgt aaaagaaaat aatattaatg
     7861 ttatttggga gaaaaagggc aaaaggaagt taatattaga tggagaaagt agaaaaaata
     7921 atgaaatagc attagatttg ctaaatcaag gaaaagatat acaaagtatc agtcaagaaa
     7981 tagaagtttc actgtcaacc attattggat atgtgcatga ctatgtaaag gatggacata
     8041 gtatatcatt tgaattagga ctagaaaatt tttataatga agataaaaag aagatgattt
     8101 tagaagtttg cgaaaaagtt ggctatgata atttaaataa cataaaaaga aaacttccag
     8161 attcaataaa gtatgaaaat ataagagctg tgatacttga ctcttatctt gaaaacttaa
     8221 aaaataatat tatagcagag taatttttaa cttaataaaa aataaaattt gtattattgt
     8281 gttgaactaa taattttgct gtgttatact gaatttgtaa aaataatgaa aaattagagc
     8341 taggggcgct agaattggct agctgagaga taaagccgta acttacaaac cctaataacc
     8401 tgatcaagat aatgcttgcg aagggaagct ttttaatata attttattat ataaataggc
     8461 aaattattca atgttaggag aaatttgtct aagtgtatat acgattataa gagtgctttc
     8521 caaacgagga aaagcacttt ttttattttc aaaaactata actttaatct tggaggattg
     8581 taatatgaac tatacaacac aaatggatgc tgctagaaaa ggcataataa ctaaagaaat
     8641 ggaaatcgtt tctcaaaaag aacaggtaga tgtaaatgaa ttaagagaat taatagcaaa
     8701 tggacaagtt gttataccag ctaataaaaa tcataaatct ttaagtgcag aaggtgtagg
     8761 taaaaattta agaacaaaaa taaatgtaaa tctaggaatt tcaagagatt gtaaggatat
     8821 agaaaaagaa cttgaaaaag ttagagtagc aatagacatg aaagctgaag ctataatgga
     8881 tttaagtaat tatggcaaaa ctagagaatt tagagaaaag gttgttgaaa tgtcacctgc
     8941 aatgataggt tcagtaccta tgtatgatgc agtaggatat ttggaaaaag aattaaaaga
     9001 tataacagaa gaagagtttt taaatgtaat aagacaacat gctattgatg gagtagactt
     9061 tattactata catgcaggtc ttacaagaag tgtttgccaa aaaataaaaa atcatgagag
     9121 attgactcat atagtatctc gtggaggttc tttattgttt gcatggatgg aattaaataa
     9181 taaggaaaat cctatttata ctaattttga taaaatattg gatatatgtg aagaatatga
     9241 tgttacattg agtttaggag atgcttgtag accaggttgt ataaaagatt ctactgatgg
     9301 tgttcaaatt caagaacttg tagtattagg tgaacttact aaaagagcat gggaaagaaa
     9361 tgtacaagta atgatagaag gtcctggaca catggctatt gatgaaatag aagcaaatgt
     9421 agtattagaa aagagattat gccatggagc acctttttat gttcttggac cattggttac
     9481 agatatagca ccaggttatg accatataac aagtgcaata ggaggagctt tagcatgtgc
     9541 caaaggagta gattttttat gttatgtaac tccagcagaa catttaagat tgcctaattt
     9601 agatgatatg aaagagggta taatagctgc aaagatagct gctcatgcag gagatatagc
     9661 taaaaatgtt aaaggtgctc gtgaatggga taataagatg agtaaagcta gagctgattt
     9721 agactggtgt gagatgttta gacttgcaat agaccctgaa aaagctaaga gatacagaga
     9781 tgaatcaact cctactcatg aggatagttg tactatgtgt ggaaaaatgt gctcaatgag
     9841 aacagttaag aaaatattaa acaatgagga acttaatcta atataatttt tggctagtat
     9901 gactggaata aaaataagct gaaaagagga ggtgatttag tgaaggttaa tgggaaggaa
     9961 attgaatttg aaaaagattt gactgttata gatttattaa ataaatataa tttaaaaagt
    10021 gatagagttg tagttgaagt gaatttagag ataattgaag aatctaacta caatacatat
    10081 gtattaaaag acgaggacat tgtagagctt attagcttta ttggaggtgg ttaaaataaa
    10141 aatatttgta aatgaattat taacagatgt tgaggaaaat acaactgctt ataaagttag
    10201 agatagctat aacaataaat gtgatgtatt ggtgttaaat ggatatccaa ttaaaacaga
    10261 tatgaccctt tgtgaaaatg ataaattaac acttatacaa aaaggagtta agccatcact
    10321 tgatgaattg gaaagcttgt tgattgctag acatactcca aatatacata ataaattaaa
    10381 aaaagggaaa gttgctatat tgggattggg gggacttggt tccaatatag ctatctcttt
    10441 agctagaata ggagtgggag aacttttact tatagattat gatgttgtag aaccatctaa
    10501 tttaaataga cagcagtatt ttatagatga tataggaaaa ctaaaaactg atgccatgat
    10561 agaaaatata aaaaaaataa atccatttat aaaattaaat aaacgagata tttttttaaa
    10621 caagaacaat atggatacta ttaaggattc agatttaata attgaggcct ttgatgatgc
    10681 ttcatgtaaa gcacaggtat gtaattatgt attaataaat ttaaaagata aatatttaat
    10741 agcatcatct ggtatggcag gttactatga ttcaaatata ataactacta agaagataaa
    10801 agacaggttt tatatatgtg gggattttgt gaatgaagct aaatttggtg aagggcttat
    10861 ggctccaagg gttgccatct gcgcaaatca tatggcaaat ttggcaacgc aaatacttat
    10921 agatatgtaa atattaaaat tagatataaa aaagattgaa tattaaaaaa atttaacgtg
    10981 gagggaaata atatggataa attggtactt ggtggacatg aatttaatag cagattattg
    11041 gttggaacag gtaaatatgg ttcaaataat atattgcctg aggtaataaa agaaagtgga
    11101 agtgaaataa taacaatggc acttagaaga gtggatttag acaataaaca agaaaacata
    11161 ttaacgtata ttccaaaaga gatgacaata cttccaaata catcaggagc tactaatgca
    11221 gaagaagctg taagaatagc tagaatatct agaaaaatgg gatgtggaga ttttataaaa
    11281 atagaagtaa tatcagatac tagatattta cttcctgata atgaagaaac tataaaagct
    11341 acaaagatac ttgctgatga ggggtttata gttcttccat atatgacacc agacctttat
    11401 gctggaagaa gacttataga agctaatgca gcggcagtta tgccacttgg agctccaatt
    11461 ggttcaaata gaggtcttca aatgaaagaa atgataagaa taatgataga tgagttggat
    11521 ataccaataa tagtagatgc aggtattgga aaaccatctc aagctatgga ggctatggaa
    11581 atgggagctg atgcagtact tgtcaacact gctatagctt cagcaggaga ccctgtacaa
    11641 atggctagag catttaaatt agctgtagaa ggtggaagag aagcatatat tgcaaaaaca
    11701 ggaaatgtgt cagaatttgc aaatgcatct tctcctttaa caggtttttt aggcaattta
    11761 tagaaagtgg tgattggtga tgagttttta tgatgtaata gaaaaatata gggattttga
    11821 ttttgatgga tatttaaata atgttactga taatgatgtt ttaagaagtt tatcaaaaga
    11881 caagcttgaa gattttgata tattaaattt gctttctaaa actgcagtaa aacatttaga
    11941 agatatggca caaaaagcac ataaattaag tgttcaatac tttggtaaaa cagtatgttt
    12001 atatacacca atgtatatag caaattattg tgttaatcaa tgtgtttatt gtagctataa
    12061 tataaagagt ggaataaaaa gaaaaaaatt aactatggat gaaattagag aagagggaga
    12121 agtaatttca aaagaaggtt tcaaacatct acttgttttg actggagaaa gtagttttca
    12181 ctcaagtgta gaatatatag gtgaggctat agaaatatta agagagaaat ttccctctat
    12241 aggtatagaa gtttatccaa tggaagtaga agaatataag tacattgtag ataaaggtgt
    12301 tgaaggatta acagtatatc aagaaactta tgacgaggaa atatataaga gagtacatat
    12361 aaaaggccca aaatcaaatt ataaatttag actagatgct cctgaaagag gggcaaaagc
    12421 aggtatgagg actttatcaa taggtgcact tttagggcta aatgatttta gaaaagaaac
    12481 tttttttaca atattgcatg ggaaatactt aaaaacgaaa tatcctcata ttgagctttc
    12541 atattcaaca ccaagaatga gaccttttaa agggtgtttt gaggaattgg tagatataag
    12601 tgatactgat ttagttcaag ctatggtatg tatgagatta tttgaccctc atgcagctat
    12661 aaatatatcc actagagaaa atttagaaat gagaagtcat ataatacctt taggagtaac
    12721 taaattgagt gcaggtgtat ctactgatgt aggaggtcat tctcaagatg aacatgatac
    12781 tgctcaattt aagataaatg atgaaagtac tgttaaagat gtggagaaaa tgctaaactc
    12841 aattggttat cagcatgtgt ttaaagattg ggaaagattt taaatgtatc tgataacaaa
    12901 cagaaaatta tgtagtgagg aacgatattt agaagttatt aaagagtcta tattgagtgg
    12961 tgtagaaaat ataataataa gagaaaagga tttagaatat caagagctaa gaaaattata
    13021 tatgaaaata aaaactaaaa tcaattgtat agattttcaa gagcaaatat cagatgaaag
    13081 tttgaaaact aatataaatc aaaaagagtt tagaaataaa ttcaaggtta attttataat
    13141 aaatagtaac attgaatttt ttgaaaaagt ggattgtcaa ggtatccatc ttccttttaa
    13201 attattcttg aatttaattg aaaataagta taattttaat gaaaataaaa tactaggatt
    13261 atctttacat aaagtagagg aagtagatta tttagaaaaa ttaataagaa atcaaaatat
    13321 aaaaatagat tacataacat tatcacatat atatgaaact aaatgtaaag aaggattaaa
    13381 tccaaaagga attgagcttt taaaagaagc taaaaagatt actgatatta aaataattgc
    13441 acttggggga attttaccat ctaatgtcaa ggaaacatta aaatactgtg atgattttgc
    13501 tataatgtca actataatga ggtctaaaga tattaaaaaa accatatcaa attataatga
    13561 aaagttgaat tagtaaatat agtatattga atttttaact taaataaaaa taaaaaagtt
    13621 atcttttaaa ttttaaaagg tagctttttt attttatatc tttgctaata aaaaattgta
    13681 aaaagggaaa actttagtca gagagattaa acaatatcct agaaagattt aaaatttagt
    13741 aaagtatgga ggacattata atgactgaca gtaaaaagaa acgatttatt ataccacaca
    13801 cttttacaat aatattttta ctaatagtct tgatggcaat attgacttgg atagtaccaa
    13861 gtggtgaatt tagtagagaa gatgtagaag gtagaatggt agttgtacca gggacttatc
    13921 aaagtgtaga aagtaatcct caaggatttg cagatgtttt taaagcacca atagaaggct
    13981 ttatcgattc agctgaagtt gtaggttttg ttttaatagt tggaggtgct tttggtattg
    14041 taaataggac tggagctata gaagcaggaa tagcttcggt tatctctaag tttaagggaa
    14101 aagaacttct tataattcca atatcaatga ttttatttgg acttggaggt acaacatttg
    14161 ggatggcaga agagacatta ccattttata tgatatttgt tccactcatg acatccttgg
    14221 gatatgattc tctaacagca atagcaattg tatttatagg agcagcagca ggagcagccg
    14281 cttcaacaat aaatccattt tcagttggta ttgcacaggc actagctcaa cttgctcctg
    14341 gttcaggagt aacttacaga gtagttattt ttatagcata tatactaata agtatagcat
    14401 ttgttatgta ctatgctaag aaggtaaagg aaaatcctga aagttcaata gtatatgaaa
    14461 tagataaaaa taataaatca atacttaatc aaacttcaac agaaataaaa gaatttactt
    14521 ttaaagaagt atctgttctt gctatatttg gaatagggat ggcaataatg atttggggtg
    14581 ttttaagtca aggatggtac attccagaaa tatcaatgtg ttttgctgca ataggtgtgc
    14641 tttctggatt ggttggtaga ttatctcaaa ttgaaatctc agaaagtttt atagatggag
    14701 caaaagattt agcatctgca gctcttgcta tagctttggc tcgtggaatc gtaataattg
    14761 ctcaaaatgg atttataata gatactatat taaattccgc agcagccttt ctaggtgggc
    14821 ttccaaaggt tatatttgta tatttatcat ttttcttgga agctgcattg gcatttttaa
    14881 ttccatcatc ttcaggtctt gcttcactta cagtacctgt acttgctcct cttggtgatt
    14941 tggttaatat atcggctcaa gtgatagtaa ccgcttatca atttggtgtg ggtcttacaa
    15001 actttataac tccaacttca ggagtactga tgggagcact tgcagtagcc catattccat
    15061 tttcaaaatg ggtaagattt ataatgccta tcttgttgat tttgacagct gtatctctag
    15121 tctttttaac aataggtatt tatatagggt tttaattaag tgtagtttta tttaagatat
    15181 ttagtaatgg tataaaatga taatatgttt tcaataaatt gccactaatt taattagtgg
    15241 taatttgttt tttgtattta aaaataaatg tatttacttg tattttgaat taatatctac
    15301 ttagacattg ttttaattgt tatattttta tttaattaag cattgattta tcatttttta
    15361 tatttcatat aacaatgcaa aaaataattt ttatatagta aatgacaaaa gtttacaata
    15421 aatgtatatt ttcttactca ttccttaaaa ttactcattt agtttaataa ctctcatttc
    15481 atatgtaaag ttggtaaaaa aattaaaatt aaaagtaaaa aactaaataa attaatgtta
    15541 atttgaaata tatatgaagg tttttggaga atacttactt atgataggaa aaaatgttaa
    15601 aataatagtg taatcaaata taaaggactg aaataattaa cagttattaa atattaggag
    15661 tgtaaaaatt tatgggatta aaagaatttg attttattga agagtctatt gatatgttga
    15721 ggacaatgtc accaacatta gaaactatat cagatgaaat agaagaatat tttgaaaata
    15781 tcttggatga aaagaatcaa gaatatataa atgtaacctc tagaataaaa tcagaatcaa
    15841 gtttaagaga aaagataatt agaaatagat atttaaaaaa atatggagaa gcaagtaatc
    15901 ttattcataa tgtttctgac ttaataggcc taagaattga gtgtagattt attgaggatg
    15961 aaaacaaaat atatagactt ttgagaagat attttaataa aacagatgac aaaataaact
    16021 attataataa agagaataag aatattaaat taaaactatc tgagaggcaa cccaataagc
    16081 aaaaaaatgg atttgaaata tataaaatag atggagtttt tgcgtattta gatagagaag
    16141 taaaatttga acttcaaatt aaatctcttg taaatgtgtt ttggagtgaa atagaacata
    16201 aaataattta taaaaacaat acatatttac ttgctgataa atttataaag gatatgatgg
    16261 actctataaa gaataatctt actatgatag ataatcagct tttaagtatt tataaaaact
    16321 ttcattcagg gaagtctttt aatatgaaag taagtaaaaa agaaattgaa aaattatttg
    16381 cgaaactagt ctatgacgct ttttctgaaa agatgaataa aagtataggt tttgttgtag
    16441 attttaaaaa accatgtgag actatattga actattcttt taataaacaa gatataagtg
    16501 atgaagtttt aggtaatttt atgcttgatg agtttgcaag attaaatgaa attgtaaaca
    16561 aggatataga ttttaatgag caaatagaat ttgaaagaga accaacattt gatgataagt
    16621 tttgtaaaga cctaggaaat cattttagaa gtagattaaa cacagaattt ccatggaacc
    16681 tattttttag aatattattt gaaatagagc catataacaa taccaaagac tttgaaaact
    16741 ttgtagagtt tataaaagaa aatgtgctac tagaagaaaa tagggagcaa ttattatgcc
    16801 aatttgaaga ggatagtaag cttataattg aagatatata tgattgtata tttaatagta
    16861 taagtgagat tgatagtgtt gaaattttat ataactataa tcttgaaaaa ataaacttta
    16921 catcaagtga aatcataaat tgtatatgta gagaatatga gtgttatggt gaatacttag
    16981 aagaaaaaga aaagcttatg aatacattta aagaaaagat tattcaaatc tttgagtaat
    17041 aggtcaatgc tgaagtggcg ctaatgcgcc atttttcaaa tatatatgaa ttaagtaaaa
    17101 ttattttgga ggaggcgatt tgtatagaga aaacaggtgt aattttggca gggggaaaaa
    17161 attctagaat gggtagagat aaagcctttt tagagttaca tgataagctt tttattgaaa
    17221 ttgcaataga agcatttaaa aactttgatg agttgataat aatatctaac aatgaagaat
    17281 tatattctaa atacgatatt aaagtttata atgatatagt aaaagatgtt ggtccaattg
    17341 gaggaatata tactgctctt gaatatgcaa agtatgatat agttacaatt gcatgtgata
    17401 tgccatatct aaataatcaa atagtcgaaa gaatagctaa taaaatggat gataaaagtg
    17461 tgatttcagt gacaaatgga aagttacaac cattgtgttc tggatataaa aagagtataa
    17521 taaataaagt atctttatgt ataagggaaa atgatttaaa gctcagaagc tttatagata
    17581 aaatagataa aagttatata tactttgatg aagaagattt atttttaaat gtaaacactg
    17641 ttgatgagta taaaaaatta actaaagttt aattagctat ggttgtaaaa tagagtagga
    17701 tttatatgga ggagagttta tgaatttact taaatgcgat tcttgggcag taatattaaa
    17761 taatagcgat aaagaaagta aagcatataa aatattagat gaacttaaaa ggaatatgta
    17821 caaagttgtt gctatagatg aagagaaaaa acctattgaa ggaatagatg tgtatgaatg
    17881 tttaaaagat gttccacaca atattgatgt tgtagctatt attgataaac aatctaagat
    17941 ggatgtgatt ttagaagaag tagagctttt ggatatacaa aatatgtggt ttgaaaaagg
    18001 aagctttagt gaaatgatga ttaaaaagac taaagattta aaattaaata tagaatataa
    18061 tttaagttta tatgatgagt tgactagata aaattatatt tcttaataat aaaaatataa
    18121 ttagttaata aaacatatta ttttatagta tagattggtt aataaaagta cagattggtt
    18181 aatgaaacat taaattacaa tatttgttaa aaaaattgtg agttacatga tataatgtat
    18241 taaataggat actaaggagt tgatatatta tgttaatagt aactacagaa aaagtagaag
    18301 gtaaaaagat atcaaaggtt ttaggattag tgagaggaag tacaataaga gcaaaacatg
    18361 ttggaaaaga tataggagca agttttaaga atcttgttgg aggagaactt actggatata
    18421 atgaaatgct cactgaagca agacaaattg ccataggtag aatggttgaa gatgcagaag
    18481 ctaaaggtgc aaacgcagta atagcattta gactgtcttc agcttcagtt atgcaaggag
    18541 cagcagaaat gcttgcttat ggaacagcag ttgttttaga agatgataat agtattcttg
    18601 aaaaataaaa tataaatagt taaaaagagg catcttttaa aaattttatg gatgcctttt
    18661 tttatttgaa aaaactaatt tgagaagaaa ttttaactat tatgacaata aaattagggt
    18721 gatattatat aaataagtaa aattatatta tataatgtat ggtatagact ttaaaaattt
    18781 tatttgtaga gaaaaatatg gacaatgtta taataattat agaaattaaa agtacttaca
    18841 ttcattatgt atgtgacatg tataattagt tttatattta atacagtttt gaagtaatat
    18901 cttcattttg agaacgttgg aataataaaa aatgtattat tataggtgat ataaataaaa
    18961 aataaatata atatgttata ttgctgatag aaaagagaat aaaagaaaat aggttttatt
    19021 aaaagagatt tttatttata ggacttaatc aatgtataga ggggtgagaa catatgttta
    19081 atgttgcaat tataacactt agtgataaag gatatgaagg aaaaagagaa gatataacag
    19141 gaaaaaagtt aactgaattt gttgaaaata caggagttta taaagttact gaatatgtac
    19201 ttataaaaga tgataaggaa atgctaaagg aaaatattat aagactttgt aatagtaata
    19261 aaatagattt aattcttaca aatggaggta ctggtttttc aaaaagagat ataaccccag
    19321 aagcaactaa ggaagtgttg gaaaaagaaa taccaggtct gagcgaatat atgagaatga
    19381 aatccacaga aattactaaa aaggccatac taagtagggg tgtgagtgga ataagaaata
    19441 attctataat aataaattta cctggaagtc ctaaaggtgc agttgaaaat ctaagtttta
    19501 taattgatgt tttagaccat ggcatagaag ttttaagagg agaagctaca gaatgtgcca
    19561 ctaaaaaaag tgaatagtat ataatctaga tagataaaaa atagacaaag aggtagataa
    19621 agtatgattg ataagtatgg aagaaaaata gactaccttc gtatttcact tacagataag
    19681 tgtaatttaa ggtgtgtcta ttgtatgcca ccagatgtaa aatttgataa aaattatata
    19741 aatgaaaatc taagctttga agactacaag tttattataa aggctatggc tgaacaaggt
    19801 ataacaaaaa ttagatttac tggaggagaa cctcttttat atcctaaatt aaatgagctt
    19861 ataaaattta caaaagaaga atgtggaata aataacatag gaatgaccac taatgctatt
    19921 ggtctttctg atagaatttt tgagcttgaa aaatgtggct taaataaagt taatataagt
    19981 ttagattctt tgaaggaata taagtataaa tccataacaa gaggaggaaa cttaaaagat
    20041 gtcttaaaat cgattgaatc ttgtttaaat ttaggtataa aagtaaagtt aaattgcgtt
    20101 gctataagtg ggtttaatga tgatgagctt aaagatttta tgtttttaac agttaaatca
    20161 ccaattgatg taagatttat agagcttatg ccattaggtg aggctaatag agtttataag
    20221 aagggttatt ttaatgtaaa agaaatgatt gaaaaaatat atggtttata taaagtcaaa
    20281 aatgatgaaa aaagtacagc agaatattat atgtttaaag gagctaaagg aagaatagga
    20341 attataactc cattaagctg ttcattttgt aacacttgta atcgtattag acttacttct
    20401 agtggtgcaa taaaattatg tctacattca aaagaagaaa tagatataaa accattttta
    20461 cataaaccat tgttatttag agaatctatg aaagatataa taaaacaaaa accagaaaaa
    20521 catcatttaa tagaaaataa atgtagtgat acaaataggc gtatgtatga aattggagga
    20581 taagtaatgt taacacatat aaatgaaaaa gggtatgcca agatggtgga cataagtgaa
    20641 aaagatgata ctaaaagaac ggccgtagct acagctacaa ttactcttag taaggaagca
    20701 ttagaaaaag taaaaaatgg tcagataaaa aaaggagacg tattgtctgt agctcaagtt
    20761 gcaggtataa tgggagctaa aaatacatct tcaaacatac caatgtgcca tcagattaaa
    20821 ttagttggat gtgatttaga atttgatgta gatgattcta tgtctgctat taagatatac
    20881 gcaacctgta aatctcttgg gaaaactgga gtagaaatgg aagctttaaa tgcatgttct
    20941 ttagcagcac ttacaattta tgatatgtgt aaagcagttg ataaaaaaat ggttataagt
    21001 aatatccatc ttgtggagaa gactggtgga aaatcaggag attttaagtt cgagtaaatt
    21061 aataatatat tgggttaaaa tttggaggaa atatggcgaa ggtagtgtca ataaatataa
    21121 gtgagaaaaa gggtgtaatt aaagttcctg tacaatgtgc agagctaaaa ataaatcatg
    21181 ggatagttgg agatgcacat gcaggaaact ggcatcgtca gataagctta cttggaaaag
    21241 aaagcataga taaaatgaaa atgaaaggct ttgaccaatt aaaatatgga gattttgctg
    21301 aaaatgtaac tacagaaggg atagaagttt tttccctgcc tgttggtaca aagttaagaa
    21361 tagggcaatg tgaagttgaa gtaactcaaa tagggaaaaa atgtcacaat ggatgtgaaa
    21421 ttaagaaatt gacaggtgac tgtgtgatgc cacgagaagg aatttttgta aaggttctaa
    21481 aagaaggaat tataaatgtg aatgattcaa tagatgtaat ctaatgaagt cactattaaa
    21541 atataattat aagtaaatac tattaagatt taaatatata ttttaagaga gaattaattt
    21601 taataaaata ttttagttat aaattggaat at
//
LOCUS       DAEHWM010000074        21216 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.075, whole genome shotgun sequence.
ACCESSION   DAEHWM010000074 DAEHWM010000000
VERSION     DAEHWM010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 21216)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21216)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21216
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.075"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..516
                     /gene="tuf"
                     /locus_tag="KNP36_002680"
     CDS             <1..516
                     /gene="tuf"
                     /locus_tag="KNP36_002680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887863.1"
                     /note="EF-Tu; promotes GTP-dependent binding of
                     aminoacyl-tRNA to the A-site of ribosomes during protein
                     biosynthesis; when the tRNA anticodon matches the mRNA
                     codon, GTP hydrolysis results; the inactive EF-Tu-GDP
                     leaves the ribosome and release of GDP is promoted by
                     elongation factor Ts; many prokaryotes have two copies of
                     the gene encoding EF-Tu; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HBF0874541.1"
                     /translation="GTVATGRVERGVLKVQDEVELVGLTEAPRKVVVTGVEMFRKLLD
                     QAQAGDNIGALLRGVQRNEIERGQVLAKTGSVKAHTKFTAEVYVLKKEEGGRHTPFFD
                     GYRPQFYFRTTDVTGACKLPEGIEMVMPGDNVTMEVDLINSIVVEEGLRFSIREGGRT
                     VASGVVATIIE"
     gene            888..1199
                     /gene="rpsJ"
                     /locus_tag="KNP36_002681"
     CDS             888..1199
                     /gene="rpsJ"
                     /locus_tag="KNP36_002681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HBF0874542.1"
                     /translation="MAKNEKIRIRLKSYDHKLLDFSAGKIVETAKKAGSQVSGPVPLP
                     TEKQVVTILRAVHKYKDSREQFEIRTHKRLIDIANPTPKTVDSLMRLDLPAGVDIEIK
                     L"
     gene            1291..1920
                     /gene="rplC"
                     /locus_tag="KNP36_002682"
     CDS             1291..1920
                     /gene="rplC"
                     /locus_tag="KNP36_002682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HBF0874543.1"
                     /translation="MKGILGKKVGMTQIFTDKGVVIPVTAVEAGPMVVTQIKTVDKDG
                     YNAIQIGFEDAKEKALNKPKKGHLAAANVLKKHLKEFRVDSVEGYTVGQEIKADVFEA
                     GAKIDVTGISKGKGFQGPIKRHGQSRGPETHGSRYHRRPGSMGACSYPGRVFKNKKLA
                     GHMGSVKVTVQNLEVVKVDADKNLILVKGAIPGAKGSVVTIKEAIKVSK"
     gene            1950..2573
                     /gene="rplD"
                     /locus_tag="KNP36_002683"
     CDS             1950..2573
                     /gene="rplD"
                     /locus_tag="KNP36_002683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001127258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HBF0874544.1"
                     /translation="MPKLNVLNVSGQNVGEIELSDSIFGVEVNGHVLYEVVKNQLANK
                     RQGTQSAKTRAEVRGGGRKPWKQKGTGRARQGSTRSVQWVGGGVAFAPKPRSYKYTLP
                     KKVRRLAMKSALSSKVQNSEVIVLDALNMDAPKTKEFAQILNNINAAKKALVVIADKN
                     DNVIKSARNIEGVQTALVNTMNVYDILKYDSFIITTDAVKKVEEVYA"
     gene            2573..2863
                     /gene="rplW"
                     /locus_tag="KNP36_002684"
     CDS             2573..2863
                     /gene="rplW"
                     /locus_tag="KNP36_002684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HBF0874545.1"
                     /translation="MTNPHDVIIRPVVTEHSMAEMGEKKYTFVVAKDANKTEIKKAVE
                     KVFGVSVDKVNTLNYDGKVKRMGRTQGRTSSFKKAVVKLTADSKEIEFFQGM"
     gene            2893..3723
                     /gene="rplB"
                     /locus_tag="KNP36_002685"
     CDS             2893..3723
                     /gene="rplB"
                     /locus_tag="KNP36_002685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HBF0874546.1"
                     /translation="MAIKKFRPTSPALRQMTVLVSDEITCNQPEKSLLVNLKKNAGRN
                     VHGRITVRHRGGGQKRKYRIIDFKRDKDGIPAKVATIEYDPNRTANIALLNYADGEKR
                     YILAPVGINVGDTILSGLGADIKPGNCLALKDMPVGTIIHNIELKPGKGAQLVRSAGV
                     SAQLMAKEGKNALLRLPSGEMRLVSINCKATIGQVGNIEHGNVVIGKAGRKRHMGIRP
                     TVRGSVMNPNDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKKNKASNKLIVSRRTK
                     "
     gene            3758..4039
                     /gene="rpsS"
                     /locus_tag="KNP36_002686"
     CDS             3758..4039
                     /gene="rpsS"
                     /locus_tag="KNP36_002686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003454422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HBF0874547.1"
                     /translation="MSRSTKKGPFVHARLLKKIEAMNASGNKEVIKTWSRSSTVFPQM
                     VENTIAVHDGRKHVPVYITEDMVGHKLGEFVPTRTFKGHKDDEKSNKRK"
     gene            4071..4406
                     /gene="rplV"
                     /locus_tag="KNP36_002687"
     CDS             4071..4406
                     /gene="rplV"
                     /locus_tag="KNP36_002687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HBF0874548.1"
                     /translation="MEAKATAKYVRVSPRKAGQICDLVRGKNVDEALAILKFTPRGAA
                     SIIAKVVKSAKANAENNHEMDTEKLYIASIVANQGPTMKRFMPRAMGRATTIRKRTSH
                     IEVVVKEKK"
     gene            4429..5244
                     /gene="rpsC"
                     /locus_tag="KNP36_002688"
     CDS             4429..5244
                     /gene="rpsC"
                     /locus_tag="KNP36_002688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HBF0874549.1"
                     /translation="MGQKVNPHGLRVGVIKDWDSRWFATDKKEFGNLLLEDHNIRKFL
                     KKRLYSAGVAKIEIERSANKIKMDLHVAKPGVVIGRAGAGIEALKAELEKMTKKTIIV
                     NIVEVRSTDKNAQLVAENIALAIERRVAFRRAMKQAIQRAMKSGAKGIKVSASGRLGG
                     AEMARTEGYSEGNVPLQTLRADIDYGFAEADTTYGKIGIKVWICNGEVLPTRDGVNPR
                     EESRKSDRRDNKRDNRRNDRRGNDRRGNDNRGNYRGQRPQGGSRPQRTENKGN"
     gene            5280..5711
                     /gene="rplP"
                     /locus_tag="KNP36_002689"
     CDS             5280..5711
                     /gene="rplP"
                     /locus_tag="KNP36_002689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HBF0874550.1"
                     /translation="MLMPKRVKRRRVHRGSMAGQAHKGNKVTYGEFGLVALEASWITS
                     NQIEAARIAMTRYIKRGGKVWIKIFPHKPVTRKPAETRMGAGKGSPEYWVAVVKPGRV
                     MFELAGVSEDKAREAMRLAAHKLPIKCKFVKKEDLEVKGGE"
     gene            5713..5916
                     /gene="rpmC"
                     /locus_tag="KNP36_002690"
     CDS             5713..5916
                     /gene="rpmC"
                     /locus_tag="KNP36_002690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005810148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HBF0874551.1"
                     /translation="MKAKELRDLTSEELMNKLNDFKSELFSLRFQLATGQLENTARIK
                     FVKKDIAKVKTVLAERKLYETRA"
     gene            5940..6194
                     /gene="rpsQ"
                     /locus_tag="KNP36_002691"
     CDS             5940..6194
                     /gene="rpsQ"
                     /locus_tag="KNP36_002691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HBF0874552.1"
                     /translation="MERGRRKVRIGRVVSDKMDKTIVVAVEEFVRHPLYNKRVKRTKK
                     FKAHDEKNICNIGDRVKIMETRPLSKDKRFRLVEVVEKVK"
     gene            6220..6588
                     /gene="rplN"
                     /locus_tag="KNP36_002692"
     CDS             6220..6588
                     /gene="rplN"
                     /locus_tag="KNP36_002692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007885948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HBF0874553.1"
                     /translation="MIQQESRLRVADNSGAKELLCIRVLGGSKRRYGNIGDVIVATVK
                     SATPGGVVKKGKVVKAVIVRSKQGVRRNDGSYISFDENAAVIIKDDKTPVGTRIFGPV
                     ARELRDNEFMKIVSLAPEVL"
     gene            6612..6917
                     /gene="rplX"
                     /locus_tag="KNP36_002693"
     CDS             6612..6917
                     /gene="rplX"
                     /locus_tag="KNP36_002693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HBF0874554.1"
                     /translation="MRVKKGDTVVVIAGKDKGKKGSVLKVYPKTSKVLVEGVNVITKH
                     QKPSAMNQQGGIINKEAPIHISNVMPFDPETGKGVRVRYEVKDGNKVRVSAKSGKEL"
     gene            6947..7489
                     /gene="rplE"
                     /locus_tag="KNP36_002694"
     CDS             6947..7489
                     /gene="rplE"
                     /locus_tag="KNP36_002694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018590379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HBF0874555.1"
                     /translation="MASRLQEKYMKEVAPALMEKFGYKNVMEIPKLNKIVINMGIGDA
                     RENPKGLEKGVEELEMISGQKPVITKARKSVANFKLREGMPIGTKVTLRADKMFYFMD
                     KLVSVSLPRVRDFRGVNPNAFDGRGNYALGVKEQLIFPEIEYDKIDKVRGMDIIFVTT
                     AKTDEEARELLKLLGMPFSK"
     gene            7507..7692
                     /locus_tag="KNP36_002695"
     CDS             7507..7692
                     /locus_tag="KNP36_002695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type Z 30S ribosomal protein S14"
                     /protein_id="HBF0874556.1"
                     /translation="MARKAMVVKQQRKQKYATREYTRCTICGRPHSVLKKFGICRICF
                     RELAYKGQIPGVRKASW"
     gene            7725..8123
                     /gene="rpsH"
                     /locus_tag="KNP36_002696"
     CDS             7725..8123
                     /gene="rpsH"
                     /locus_tag="KNP36_002696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HBF0874557.1"
                     /translation="MTMTDPIADMLTRIRNANVVKHETVDVPASNMKKELARILLEEG
                     FIRGYDVIEDGKQGIIRIQLKYGQEGERVITGLKKISKPGMRVYAANHEIPKVLNGLG
                     ISVISTSKGILTDKQARKENVGGEVICYVW"
     gene            8154..8696
                     /gene="rplF"
                     /locus_tag="KNP36_002697"
     CDS             8154..8696
                     /gene="rplF"
                     /locus_tag="KNP36_002697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HBF0874558.1"
                     /translation="MSRIGVKPIIIPAGVEVTIAEGNLVTVKGPKGTLTKQLSAELNI
                     KKEENTIMVERPTDNKKHRSLHGLTRTLLDNMVVGVNTGFEKKLELKGVGYRAQKQGK
                     KLVMNLGFSHPVEMEDPEGITVEAPNQTELIVKGIDKQLVGNYAAKIRAWRKPEPYKG
                     KGIKYVDEVIRRKEGKTGKK"
     gene            8732..9100
                     /gene="rplR"
                     /locus_tag="KNP36_002698"
     CDS             8732..9100
                     /gene="rplR"
                     /locus_tag="KNP36_002698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HBF0874559.1"
                     /translation="MLKKADKNANRLQRHKRVRRKISGTSQRPRLCVFRSANNIYAQI
                     IDDTKRVTLVAASSLEAEVKSAVNHTGNKEAAKKVGELVAKKAVEKGITEVVFDRGGY
                     LYHGRIQELAEGAREAGLKF"
     gene            9121..9630
                     /gene="rpsE"
                     /locus_tag="KNP36_002699"
     CDS             9121..9630
                     /gene="rpsE"
                     /locus_tag="KNP36_002699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HBF0874560.1"
                     /translation="MLRRKPIDAGQLDLQEKVVEVRRVTKVVKGGRNFRFAALVVVGD
                     ENGHVGIGAGKAMEVPDAIKKAVEDAKKNLIVVPIVGTTIPHEVRGHFGAGNILIMPA
                     VEGTGVIAGGPARAVLELAGLKDVRAKSLGSNNPRNMVNATIEGLNSLKTVEDIAKLR
                     GKKVEELLG"
     gene            9645..9830
                     /gene="rpmD"
                     /locus_tag="KNP36_002700"
     CDS             9645..9830
                     /gene="rpmD"
                     /locus_tag="KNP36_002700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HBF0874561.1"
                     /translation="MAKLQIKLVRSVIGTTPNQKKNVEALGLRKREQVVVKEDNAQTR
                     GMINKVSHLLEVTEIAE"
     gene            9863..10306
                     /gene="rplO"
                     /locus_tag="KNP36_002701"
     CDS             9863..10306
                     /gene="rplO"
                     /locus_tag="KNP36_002701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HBF0874562.1"
                     /translation="MKLHELKPAEGAVRAKRRLGRGTATGQGKTAGRGQKGQWSRSGG
                     GVRVGFEGGQMPLARRLPKRGFNNIFKKVYTEVNVEVLNRFENGTEITAELLKSTKTI
                     SKIGKDGIKILGEGNLEKALTVKAAKFTASAQEKIEKAGGKAELV"
     gene            10350..11618
                     /gene="secY"
                     /locus_tag="KNP36_002702"
     CDS             10350..11618
                     /gene="secY"
                     /locus_tag="KNP36_002702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HBF0874563.1"
                     /translation="MLSKLKQAWKIKAVRKKVMYTLMMIVIFRIGTTIPVPGIDTSII
                     QKMVGGNSLLSLYNMFTGGAFSNFSLFALGISPYITASIIIQLLTVGFESLAELQKSG
                     EEGKKKINKYTKYTALALAVVQALGITLGIVRSALISNSVFFITTVVITLVSASMLVM
                     WIGDKITEKGIGNGSSVIIFAGIISRIPTDVIKISQQVKSGEVAPWVIVILAVVILLT
                     VTGVTFIQEATRKIPVQYAKRVVGRKMYGGQSSHIPMKVNQSGVMPIIFASSLLAFPQ
                     TIAMFMGPNAQAFVQKYLSMATEQGFWTYRSIEILLIIFFSYFYTTVSFNTEDISKNM
                     KNNGGFIPGIRPGEPTMDYLNRILTRLTLAGATFLAIIAMVPALTTHYMKVNMSLAGT
                     SLLIVVGVALELKRQLESNLVMRSYQGFLK"
     gene            11635..12285
                     /locus_tag="KNP36_002703"
     CDS             11635..12285
                     /locus_tag="KNP36_002703"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HBF0874564.1"
                     /translation="MRIILLGPPGAGKGTQAAGIVEKYNIPHISTGDIFRKNIKEGTE
                     LGKKAKEYMDQGLLVPDELTVGLVTDRISQEDCKNGFMLDGFPRNVAQGEHLDIFLKN
                     AGISLDKVVNIEVDKSILVSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQR
                     ADDNEETVSKRIQVYLDETKPLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK"
     gene            12286..13032
                     /gene="map"
                     /locus_tag="KNP36_002704"
     CDS             12286..13032
                     /gene="map"
                     /locus_tag="KNP36_002704"
                     /EC_number="3.4.11.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I methionyl aminopeptidase"
                     /protein_id="HBF0874565.1"
                     /translation="MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIA
                     EENIRKYNAEPSFKGYGGFPGSICASINREVVHGIPGETILQEGDIVSLDIGAYYKGY
                     HGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS
                     VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGW
                     TTVTIDGKKSAHYEHTIAITEHEPLILTKL"
     gene            13054..13323
                     /locus_tag="KNP36_002705"
     CDS             13054..13323
                     /locus_tag="KNP36_002705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KOW domain-containing protein"
                     /protein_id="HBF0874566.1"
                     /translation="MLSDNLSIGQVVKVSLGRDKGNLFFVVKIINNEYVLIADGKKRK
                     LDKPKLKKVKHLKKYNFINDEVRKRVVSGQEITDSFLRAELTKLN"
     gene            13361..13579
                     /gene="infA"
                     /locus_tag="KNP36_002706"
     CDS             13361..13579
                     /gene="infA"
                     /locus_tag="KNP36_002706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001029884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HBF0874567.1"
                     /translation="MAKKDVIELEGTVSEALPNAMFKVKLENGHEILCHISGKLRMNF
                     IRILEGDKVNVELSPYDLTRGRITWRKK"
     gene            13615..13728
                     /gene="rpmJ"
                     /locus_tag="KNP36_002707"
     CDS             13615..13728
                     /gene="rpmJ"
                     /locus_tag="KNP36_002707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003720928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HBF0874568.1"
                     /translation="MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQKQG"
     gene            13881..14252
                     /gene="rpsM"
                     /locus_tag="KNP36_002708"
     CDS             13881..14252
                     /gene="rpsM"
                     /locus_tag="KNP36_002708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005810116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HBF0874569.1"
                     /translation="MARIAGVDLPREKRAEIGLTYIYGIGKATANEILAKAEINPDTR
                     IKDLSEDQVNELRKVIDDDFLVEGDLRREIALNIKRLRDIKCYRGIRHAKGLPLRGQR
                     TKTNARTRKGPRKTVSRKKKK"
     gene            14288..14686
                     /gene="rpsK"
                     /locus_tag="KNP36_002709"
     CDS             14288..14686
                     /gene="rpsK"
                     /locus_tag="KNP36_002709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006440523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HBF0874570.1"
                     /translation="MAKPKKKVTRIRRRERKNIERGHAHIQSTFNNTIITLTDVHGNA
                     ISWASSGQLGFKGSRKSTPFASQMAAETAAKAAMEHGLKSVEVFVKGPGSGREAAIRA
                     LQATGLEVTMIKDVTPIPHNGCRPPKRRRV"
     gene            14718..15341
                     /gene="rpsD"
                     /locus_tag="KNP36_002710"
     CDS             14718..15341
                     /gene="rpsD"
                     /locus_tag="KNP36_002710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HBF0874571.1"
                     /translation="MARYTGASCRQCRREGMKLFLKGDRCYTDKCAIVKRNYAPGQHG
                     QGRKKVSNYGLQLREKQKVKRIYGVLETQFRNLYERAENMPGKAGENLLSLLERRLDN
                     VVYRMGLASSRKEARQLVTHGHFTLNGNKVDIPSLIVKVGDVIEVKEKSRSSAKFKNL
                     VEVNSRIAPKWLEANVEGMTAKVVGVPTREDIDLEIAEHLIIELYSK"
     gene            15419..16366
                     /locus_tag="KNP36_002711"
     CDS             15419..16366
                     /locus_tag="KNP36_002711"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HBF0874572.1"
                     /translation="MIEIEKPKVDIVELSEDYRYGKFVIEPLERGYGITIGNALRRIL
                     LSSLPGVAVNAIKIDGVLHEFSTIPGVKEDVTEIILTLKELSATIDGEGSRTLKIEAQ
                     GPCSITGADIICPPDVEILSKDLAIATLDDNAKLNMEIFVDKGRGYVSAEENKTENVP
                     IGVLPVDSIYTPVEKVSYHVENTRVGQKTDYDKLVLEVWTNGSINPQEGISLAAKVLV
                     EHLNLFIDLTEHVSSVEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVEE
                     LANKSEDDMMKVRNLGKKSLEEVIQKLEELGLGLKPSEE"
     gene            16387..16728
                     /gene="rplQ"
                     /locus_tag="KNP36_002712"
     CDS             16387..16728
                     /gene="rplQ"
                     /locus_tag="KNP36_002712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003357477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HBF0874573.1"
                     /translation="MAKYRKLGRETAHRNLMLRNLVTCLLRSGRIETTVTRAKETRRM
                     AEKMITLAKRGDLHARRQVLAYVMDETVVNNLFTDLAPKYAERNGGYTRIIKIGPRKG
                     DAAEMAFIELV"
     gene            16848..17681
                     /locus_tag="KNP36_002713"
     CDS             16848..17681
                     /locus_tag="KNP36_002713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HBF0874574.1"
                     /translation="MDNIVKVNNISFEYITDEAKLKAIDNLSLDVKKGEFVAIIGHNG
                     SGKSTLSKNLNAILMPTEGNILIDDMDTKEEERLWDIRQTAGMVFQNPDNQIVATIVE
                     EDVAFGPENLGIEPKEIRRIVEESLKSVGMYDLRDRQPHLLSGGQKQRVAIAGIIAMR
                     PKCIIFDEATAMLDPSGRKEVMKTIKRLNKEENITVIHITHFMEEAVEADRVVVMEKG
                     KKILEGTPREVFSKIKMLKEIGLDVPCMTELSSLLIEEGINISSDILTVDEMVMELCQ
                     L"
     gene            17669..18535
                     /locus_tag="KNP36_002714"
     CDS             17669..18535
                     /locus_tag="KNP36_002714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HBF0874575.1"
                     /translation="MSIIVKNLTHIYNEGMPFASKALDDVSFEIKDRDFVGLIGHTGS
                     GKSTLIQHLNGLLKPSSGEIFINDFNITDKNLNLTEIRKRVGVVFQYPEYQLFEETID
                     KDIAFGPSNLGLEESEIHNRVKASMEAVGLDYEGFKDKSPFELSGGQKRRVAIAGVIA
                     MNPEVLILDEPTAGLDPGGRDEIFNLIKDLHEKKNMTIILSSHSMDDMAKLAKTLIVM
                     NHGSVEFMGTPREVFKSNASKLKDIGLDIPQVLELALKLREKGFDISEDILTLEEAKQ
                     EILKVVRGRGLC"
     gene            18529..19332
                     /locus_tag="KNP36_002715"
     CDS             18529..19332
                     /locus_tag="KNP36_002715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HBF0874576.1"
                     /translation="MLKDITIGQYYPTSSAIHKLDPRIKLVATIVFMVSIFVVNKFWP
                     YIVVLLCLLAMIKLANIPVKYIVKGVKPLKWIILFTFLINIFFLPGDEIWSFGFLAIT
                     KQGLRQAIFMAIRLIFLVVGTSLLTLTTSPIELTDGIERLLNPFKKIGLPVHELAMMM
                     TIALRFIPTLLDETDKIMKAQMSRGADFESKNLINRAKNLVPLLVPLFVSAFRRADEL
                     AMAMEARCYRGGHNRTKMRESVISRRDYMACVFQVVYLGAIIATRFIAI"
     gene            19364..20095
                     /gene="truA"
                     /locus_tag="KNP36_002716"
     CDS             19364..20095
                     /gene="truA"
                     /locus_tag="KNP36_002716"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003514691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HBF0874577.1"
                     /translation="MRNIKIKIQYNGKNYCGWQKQPDSLGIQGTIERAIYDITKEETS
                     LIGSGRTDSGVHAIGQIANFKINSGISIESIPMALNAKLPKDISVIEACEVNDDFHSR
                     YSAKGKTYKYLVYNSKFRNPILSEISYQVKYELDFDKMCSEAKSLLGTHDFKGFMSSG
                     SSVKDTVRTIYDIDISKKDDLITFEISGNGFLYNMVRIIVGTLVDMGRGRINEPFLDI
                     IQSKTRSRCGHTAPAQGLFLKKVHY"
     gene            20215..20646
                     /gene="rplM"
                     /locus_tag="KNP36_002717"
     CDS             20215..20646
                     /gene="rplM"
                     /locus_tag="KNP36_002717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HBF0874578.1"
                     /translation="MKSYIAKPADVQRKWYLVDAEGKTLGRLATEIATVLRGKHKPTF
                     TPHVDGGDFVVVVNAEKIVLSGKKLDQKYYRYHTGYVGGLKEISYRDMMDKKPEEVIS
                     HAVSGMLPKNKLRSRMMTRLRVFAGAEHTHAAQNPEVLNFK"
     gene            20675..21067
                     /gene="rpsI"
                     /locus_tag="KNP36_002718"
     CDS             20675..21067
                     /gene="rpsI"
                     /locus_tag="KNP36_002718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003515879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HBF0874579.1"
                     /translation="MANVQYYGTGRRKSSVARVRLVAGEGNILVNGRALENYFNYETL
                     IRDVKQPLVLTGNENKYDVIVKVEGGGFTGQAGAIRHGISRALLKADLDLRPALKKEG
                     FLTRDARMKERKKYGLKAARRAPQFSKR"
BASE COUNT         8489 a         2509 c         4448 g         5770 t
ORIGIN      
        1 ggaacagttg caacaggaag agtggaaaga ggagtactaa aagtacaaga cgaagtagaa
       61 ttagtaggat taacagaagc accaagaaaa gtagtagtaa caggagtaga gatgttcaga
      121 aaattattag accaagcaca agcaggggat aatataggag cattattaag aggagtacaa
      181 agaaacgaga tagaaagagg acaagtacta gcaaagactg gatcagtaaa ggcacacaca
      241 aagtttacag cagaagtata tgtacttaaa aaagaagaag gtggaagaca tacaccattc
      301 tttgatggat atagaccaca attctatttc agaacaacag acgtaacagg agcttgtaag
      361 ttaccagaag gaatagagat ggtaatgcct ggagataacg taacaatgga agtagactta
      421 ataaactcaa tagttgtaga agagggatta agattctcaa taagagaagg tggaagaaca
      481 gtagcttcag gagttgttgc tacaataata gagtaatcct ttactaaact aatggattta
      541 atataaaaaa aagagggggt aactcctctc ttttttgttt tttgttgaca agtagcgcta
      601 aagcatatat actaaactag tgccttgaga cagattaaca atcaagttta aggttatgat
      661 gttgtaatag aaaataaaat tgaaaaaaac agaaaaaaaa cttgaaaaaa tgtaacagat
      721 gatataaaat ataatagtgt gcttgagaga ttaagaaaat aataattaaa tcctagtgaa
      781 atacgaactg atatcgattt aaaagttaca acacacccgg agcagtgtat cggtattggt
      841 tgtacgcaac ttgaaaatta aacacgtgat aaaggaggga aaacaaaatg gctaagaatg
      901 aaaaaataag aataagatta aaatcatatg atcacaaatt attagatttt tcagcaggta
      961 aaatagttga aactgctaaa aaggctggat cacaagtttc aggacctgtg cctctaccaa
     1021 cagaaaaaca agttgtaact atattaagag ctgtacataa gtacaaagac tctagagaac
     1081 aatttgaaat aagaactcat aaaagactaa tcgacatagc taatccaaca cctaagacag
     1141 ttgactcatt aatgagatta gacttaccag caggtgtaga tatagaaata aaattataag
     1201 aacccctaag atattatcct atagatgatt atcttagaat gattactcta aaagatgtaa
     1261 tccgctgtaa gaattatagg aggtgctaat atgaaaggaa tattaggcaa aaaagttggt
     1321 atgactcaaa tattcactga taaaggtgta gttatacctg taacagctgt tgaagcaggg
     1381 cctatggtcg ttactcaaat aaaaacagtt gataaagatg gatacaatgc tatacaaata
     1441 ggttttgaag atgctaaaga aaaagcttta aacaaaccta aaaaaggaca tttagctgct
     1501 gctaatgttt taaagaaaca tttaaaagaa tttagagtag attctgtaga aggatacaca
     1561 gtaggacaag aaataaaagc tgatgtattt gaagcaggtg caaaaataga tgttactgga
     1621 ataagtaaag gtaagggatt ccaaggtcca ataaaaagac atggacaaag tagaggtcct
     1681 gaaactcacg gttctagata ccacagaaga ccaggttcaa tgggagcttg ttcttaccca
     1741 ggtagagtat ttaaaaacaa aaaattagct ggacatatgg gaagcgtaaa ggtaacagtt
     1801 caaaacttag aggttgttaa agtagatgct gacaagaacc ttatattagt taaaggagct
     1861 ataccaggag ctaaaggttc agtagtaact ataaaagaag ctataaaggt ttctaaataa
     1921 tgactaacct agagaaagga ggaataacaa tgccaaaatt aaatgtacta aatgttagtg
     1981 gacaaaacgt tggagaaata gaattatcag attctatatt tggcgtagaa gttaatggac
     2041 atgttttata cgaagttgta aaaaatcaat tagcaaataa gagacaagga actcaatctg
     2101 ctaaaactag agcagaagtt agaggtggcg gaagaaaacc ttggaaacaa aaaggaacag
     2161 gtagagcaag acaaggttct acaagatctg tacaatgggt aggtggagga gttgcttttg
     2221 cacctaaacc aagaagctac aaatatacat tacctaagaa ggtaagaaga ttagctatga
     2281 agagtgcttt atcttcaaaa gttcaaaata gtgaagttat agtattagat gcattaaaca
     2341 tggatgctcc taagactaaa gaatttgctc aaatattaaa caatataaat gctgctaaaa
     2401 aagctttagt agttatagct gacaaaaacg ataacgtaat aaaatcagct agaaatatag
     2461 aaggtgttca aactgcatta gttaatacta tgaatgtata tgatatatta aaatacgatt
     2521 catttataat aactacagat gctgttaaaa aagtggagga ggtgtacgca taatgactaa
     2581 tccacatgat gtaataataa gaccagttgt aactgagcac agtatggctg aaatgggtga
     2641 aaaaaaatac acttttgttg tggctaaaga tgcgaacaaa actgaaataa aaaaagcagt
     2701 agaaaaagta ttcggagtta gtgttgataa agtaaatact ttaaactacg atggaaaagt
     2761 taaaagaatg ggtagaactc aaggaagaac atcaagcttt aagaaagcag tagttaaatt
     2821 aactgctgat agtaaagaaa tagaattctt ccaaggaatg tagtattata acaaacgaag
     2881 gagggaaaac agatggctat aaaaaagttt agaccaactt ctcctgcctt aagacaaatg
     2941 acagttttag tttctgatga aataacatgt aatcaaccag aaaaatctct tttagttaac
     3001 ttaaagaaaa atgctggtag aaacgtacat ggtagaataa ctgttcgtca tagaggtgga
     3061 ggacaaaaaa gaaaatatag aataatagat tttaaaagag ataaagatgg tatacctgct
     3121 aaggttgcta ctatagaata tgatccaaac agaactgcaa atatcgcatt attaaactat
     3181 gctgatggag aaaaaagata tatattagct ccagttggaa ttaacgttgg agatactata
     3241 ttatcaggat taggtgctga tataaaacca ggaaactgtt tagcattaaa agatatgcca
     3301 gttggtacta tcattcataa tatagaatta aagccaggaa aaggagctca attagttaga
     3361 tctgctggag tttctgcaca attaatggct aaagaaggaa aaaatgcttt attaagatta
     3421 ccatcaggtg agatgagatt agtaagcata aactgtaaag ctactatagg tcaagttgga
     3481 aatatagagc atggtaacgt agttatcggt aaagcaggta gaaaaagaca tatgggaata
     3541 agacctactg taagaggttc tgtaatgaac cctaatgacc atccacacgg tggaggggaa
     3601 ggtagatctc caataggtag accatctcct gttactccat ggggtaaacc agctcttgga
     3661 tacaaaacta gaaagaaaaa taaagcttca aataaactaa tagtatcaag aagaactaag
     3721 tagtaaattt atttttgctc ggaaaggagg aatataaatg tcaagatcaa ctaaaaaagg
     3781 gccttttgtc catgcaagac ttttaaagaa gatagaagct atgaatgcta gtggaaataa
     3841 agaagttata aaaacttggt caagatcttc aactgtattt ccacaaatgg tagaaaacac
     3901 tatagctgtt catgatggaa gaaaacatgt tccagtatat ataacagaag atatggttgg
     3961 acataaatta ggtgagttcg ttcctactag aactttcaaa ggacataagg atgacgaaaa
     4021 atctaataag agaaaataat taaattatga ctaagaaagg aggaataaca atggaagcaa
     4081 aagctactgc taaatacgta cgtgtatcac caagaaaagc aggccaaata tgtgaccttg
     4141 ttagaggaaa gaatgttgat gaagcattag caatattaaa gtttactcca agaggagcag
     4201 cttcaataat agctaaggtt gtaaaatcag ctaaagctaa cgcagaaaac aatcacgaaa
     4261 tggatactga aaaattatat atagcatcaa tagttgctaa tcaaggacca acaatgaaga
     4321 gattcatgcc tagagctatg ggtcgtgcaa ctacaataag aaaaagaact tctcatatag
     4381 aggttgttgt taaagaaaaa aaataattaa tagataggag ggaaagtaat gggtcaaaag
     4441 gttaatccac acggcttaag ggtcggtgtt ataaaagatt gggactcaag atggttcgct
     4501 actgataaaa aagagttcgg aaacttatta ttagaagacc ataatatacg taaattctta
     4561 aagaaaagat tatactcagc tggagttgct aagatagaaa tagaaagatc agctaacaaa
     4621 ataaaaatgg acttacacgt tgctaagcct ggtgtagtta taggaagagc tggtgcagga
     4681 atcgaagcat taaaagctga attagaaaaa atgacaaaga aaactataat agttaatata
     4741 gtagaagtaa gaagtacaga taaaaatgct caattagtag ctgagaatat agctttagct
     4801 atagagagaa gggttgcttt cagaagagca atgaaacaag ctatacaaag agcaatgaaa
     4861 tctggtgcta aagggataaa agtttctgct tcaggaagat taggtggagc tgaaatggct
     4921 agaactgaag gttatagtga aggaaatgtg ccactacaaa ctttaagagc agatatagat
     4981 tatggtttcg ctgaagctga tacaacttat ggaaaaatcg gtataaaagt ttggatatgt
     5041 aatggtgaag ttttaccaac tagagacggt gtaaatccaa gagaagaaag cagaaagagc
     5101 gatagaagag acaacaagag agataataga agaaacgata gaagaggaaa tgacagaaga
     5161 ggaaatgata acagaggaaa ctacagagga caaagacctc aaggtggatc aagacctcaa
     5221 agaactgaaa acaaaggaaa ttaataatag ttaggttcaa ggaaggagga aaaatactca
     5281 tgttaatgcc aaaaagagta aagcgtcgta gagttcatag aggaagcatg gctgggcaag
     5341 ctcataaggg taataaagtt acttatggtg agtttggatt agtagcatta gaagcttctt
     5401 ggataacttc taatcaaata gaagctgcca gaatcgcgat gactagatat ataaaaagag
     5461 ggggaaaggt ttggataaaa atattccctc ataaaccagt aacaagaaaa ccagcagaga
     5521 ctcgtatggg tgcagggaaa ggttctccag aatattgggt agctgtagtt aagccaggaa
     5581 gagttatgtt tgaattagca ggtgtttctg aagataaagc aagagaagct atgagacttg
     5641 ctgcacataa attaccaatc aaatgtaaat ttgttaaaaa agaagattta gaagtaaagg
     5701 gtggtgaata ggatgaaagc taaagaatta agagatttaa caagcgaaga gctaatgaac
     5761 aaattaaacg acttcaaaag tgaattattt agcttaagat tccaattagc tactggtcaa
     5821 ttagaaaata cagctagaat aaagtttgtt aagaaggata tagcaaaagt taaaactgtt
     5881 cttgctgaaa gaaagttata cgaaactaga gcttaatttg gaaaggaggc tttttaaaca
     5941 tggaaagagg aagaagaaaa gttagaatag gccgtgttgt tagtgataag atggataaaa
     6001 caatagtagt agctgttgaa gaattcgtac gtcatccact atataataaa cgtgttaaga
     6061 gaactaagaa attcaaggct catgatgaaa agaatatatg taacatcgga gatagagtta
     6121 aaataatgga aactagacca ttatctaaag ataagagatt cagactagtt gaagttgttg
     6181 agaaagttaa gtagtttttg aagaaggagg gattacgata tgatacaaca agaatcacgt
     6241 ctaagagttg ctgataactc aggagctaaa gaacttttat gtatacgtgt tctaggcgga
     6301 agtaaaagaa gatatggtaa cataggcgac gttatagttg ctactgttaa aagtgcaaca
     6361 cctggtggag ttgtaaaaaa aggtaaggtt gttaaagctg ttatagtaag aagcaaacaa
     6421 ggcgtaagac gtaatgacgg aagctatata tcttttgatg aaaatgctgc tgttataata
     6481 aaggacgata aaactccagt aggaactcgt atattcgggc ctgttgctag agagttaaga
     6541 gacaatgaat tcatgaaaat agtttctctt gctccagaag tactataatt aaggaggtgc
     6601 aataggacat gatgcgtgtt aaaaaaggtg acactgttgt agttatagca ggtaaagata
     6661 aaggtaaaaa aggttcagtt ttaaaggtat atcctaaaac tagcaaagtg ttagttgaag
     6721 gtgtaaatgt aataactaaa catcaaaaac caagtgctat gaaccaacaa ggtggaataa
     6781 taaataaaga agccccaata cacatatcta atgtaatgcc atttgatcct gaaacaggaa
     6841 aaggcgttag agtaagatat gaagtaaaag atgggaacaa agtaagagta tcagcaaaga
     6901 gcggaaaaga attataataa atattgcttg aaaggaggga ccttaaatgg cttctagatt
     6961 acaagaaaaa tacatgaaag aagttgctcc tgctttaatg gagaaatttg gatacaaaaa
     7021 cgtaatggag atacctaagt taaataaaat agttattaac atgggtatag gtgacgctag
     7081 agaaaatcca aaaggattag aaaaaggcgt tgaagaatta gaaatgatat caggacaaaa
     7141 gcctgttata actaaagcta gaaaatctgt tgctaacttc aaattaagag aaggaatgcc
     7201 aataggaaca aaagttacat taagagctga caaaatgttc tactttatgg acaaattagt
     7261 ttcagtttct ttaccaagag ttagagactt tagaggagtt aaccctaatg cttttgatgg
     7321 tagaggaaat tatgctttag gagttaaaga acaattaata ttccctgaaa tagaatatga
     7381 taaaatagat aaagtaagag gaatggatat aatatttgtt actacagcaa aaactgacga
     7441 agaagctcgt gaattattaa aattattagg aatgccattt tctaagtaag caaaggaggg
     7501 attcccgtgg ctagaaaagc gatggttgtt aagcaacaaa gaaagcaaaa gtacgctact
     7561 agagaataca ctagatgtac tatatgcgga agaccgcatt cagttttgaa aaaatttggt
     7621 atatgccgta tatgctttag agaattagct tataaaggtc aaatacctgg tgttagaaaa
     7681 gcaagctggt agaagcttga ttagaatgga aggagggcaa caaaatgaca atgacagatc
     7741 caattgcaga tatgcttact cgtataagaa atgctaatgt tgttaagcat gaaactgtag
     7801 atgttccagc ttctaatatg aagaaagaat tagctagaat cttattagaa gaaggtttca
     7861 taagaggtta tgatgttata gaagatggaa aacaaggtat cataagaata caattaaagt
     7921 acggacaaga aggcgaaaga gttataacag gtcttaagaa aatatctaag cctggaatga
     7981 gagtttacgc tgctaaccat gagataccaa aagtattaaa cggattagga atatcagtta
     8041 tatctacttc aaaaggaata ttaactgaca agcaagctag aaaagaaaat gttggtggag
     8101 aagtaatctg ctacgtttgg taattaatat gaacaatgta aggaggtgcg accatgtcaa
     8161 gaataggtgt taagccaata ataataccag caggtgttga agttactata gctgaaggaa
     8221 atttagttac agtaaaaggt ccaaaaggaa ctttaactaa acaattaagt gctgagttaa
     8281 acataaaaaa agaagaaaat acaataatgg ttgaaagacc aactgataat aaaaaacata
     8341 gatctttaca cggactaact agaactttat tagataatat ggttgtaggt gtaaatactg
     8401 gtttcgaaaa gaaattagaa ttaaaaggtg ttggatatag agctcaaaaa caaggaaaga
     8461 aattagttat gaacttaggt ttctctcatc cagttgagat ggaagatcca gaaggaataa
     8521 ctgttgaagc tccaaaccaa acagagttaa tagtaaaagg tatagacaag caattagtag
     8581 ggaattatgc tgctaagata agagcttgga gaaagccaga gccatacaaa ggtaaaggta
     8641 taaaatacgt tgatgaagta atcagacgta aagaaggaaa aactggtaaa aaataatacc
     8701 aaaacttaaa cgctagaaag gagtgagcta gatgttaaaa aaggctgata aaaatgctaa
     8761 tagacttcaa agacataaga gagttcgtag aaaaataagc ggtacttctc aaagaccaag
     8821 attatgtgta tttagaagtg ctaacaatat atatgctcaa ataatagatg acacaaaaag
     8881 agtaactcta gttgctgcat cttctttaga agcagaagtt aagagtgctg tcaatcatac
     8941 aggaaacaag gaagcagcta agaaagttgg agaattagtt gctaaaaaag ctgttgaaaa
     9001 aggaatcact gaagttgtat ttgacagagg tggatactta tatcatggaa gaattcaaga
     9061 attagctgaa ggtgctagag aagctggtct taagttctaa tacgaaggag ggaaaaatac
     9121 atgctacgtc gtaagccgat agatgcagga caacttgact tacaagaaaa agttgttgaa
     9181 gtaagacgtg ttactaaggt tgtaaaaggt ggtagaaatt tcagatttgc agcattagta
     9241 gttgttggag atgaaaacgg acacgttggt ataggtgctg ggaaagcaat ggaagtacca
     9301 gacgctataa aaaaagcagt tgaagatgct aagaaaaatc taatagtagt gccaatagtt
     9361 gggactacaa ttcctcacga agtacgcgga cactttggtg ctggaaatat attaataatg
     9421 cctgctgtag aaggtacagg agtaatagct gggggacctg ctagagccgt acttgagcta
     9481 gctggactaa aagacgttag agctaaatct ttagggtcta acaatccaag aaatatggta
     9541 aatgctacaa tagaaggact taattctcta aaaacagttg aagatatagc taaacttaga
     9601 ggtaaaaaag ttgaagaact tctagggtaa ggaggtagtg taaaatggct aaattacaaa
     9661 taaagttagt tagaagtgtt ataggaacta ctcctaacca aaaaaagaat gttgaagcgt
     9721 taggattaag aaaaagagaa caagttgttg taaaagaaga caatgctcaa acaagaggta
     9781 tgataaataa agtaagtcac ttattagaag taactgaaat agctgaataa tttttataaa
     9841 gtagtgcaag gaggtgcaat ccatgaagtt acatgagtta aaacctgctg aaggtgcagt
     9901 aagagctaag agaagattag gtagaggtac tgcaactgga caaggtaaaa ctgcaggacg
     9961 tggacaaaaa ggtcaatggt ctcgttctgg tggtggagta agagtaggat ttgaaggtgg
    10021 acaaatgcca ctagctagaa gacttcctaa gagaggtttc aataacatat ttaagaaagt
    10081 ttacacagaa gttaatgttg aagttttaaa cagatttgaa aatggaacag aaataactgc
    10141 agaattatta aaatctacta aaactataag caaaataggt aaagacggaa ttaaaatctt
    10201 aggtgaaggt aatttagaga aagctttaac tgttaaagct gctaaattta cagcttcagc
    10261 tcaagaaaaa atagaaaaag ctggtggaaa agcagagtta gtataataac ctgctaatct
    10321 cctagccagt acaggcgggg tgaattagcg tgctgtcaaa attaaaacaa gcttggaaga
    10381 ttaaagcagt aagaaaaaaa gtaatgtata cacttatgat gatcgtgata ttcagaatag
    10441 gtactactat accagttcca ggcatagaca ctagtattat acaaaagatg gtaggcggca
    10501 atagtctact ttctctgtat aatatgttta ctggtggagc atttagtaac ttttcactat
    10561 ttgctttagg tataagtcca tatatcactg catcaatcat aatacaactt ctaacagtag
    10621 gttttgaaag tttagcagaa cttcaaaaat ctggtgaaga aggaaagaaa aaaatcaata
    10681 agtacactaa atatacagca ctagctctag cagttgtaca agctttggga attacattag
    10741 gaattgtaag aagtgcttta atatcaaata gtgtgttttt tatcacaact gttgtaataa
    10801 cattagtttc agcaagtatg ttagtaatgt ggattgggga caaaattact gaaaaaggaa
    10861 tcggtaatgg tagttcagta ataatatttg caggtataat atcaagaata cctacagatg
    10921 ttattaaaat atcgcaacaa gttaaatctg gcgaagttgc accttgggtt atagtgattc
    10981 tagctgtagt tatattactt acagtaacag gagttacatt tatacaagaa gcaactagaa
    11041 agatacctgt acaatatgct aaaagagttg ttggaagaaa aatgtatgga ggacaaagtt
    11101 ctcatatacc aatgaaagtt aaccagtcag gagttatgcc tataattttt gctagttcac
    11161 ttttagcttt ccctcaaaca atagctatgt ttatgggtcc aaatgctcag gcttttgttc
    11221 aaaaatactt aagtatggca acagaacaag gattttggac atatagatca attgagattc
    11281 tacttataat tttcttctca tatttttata caactgtatc atttaataca gaagacatat
    11341 ctaaaaatat gaaaaataat ggtggattta taccaggtat aagaccaggt gagcctacta
    11401 tggattattt aaatagaatt ttaactagat taactttagc tggagctact ttcttagcaa
    11461 taattgctat ggtgccagct cttacaacac attatatgaa agtaaatatg agtctagctg
    11521 ggacttcatt gctaatcgtt gttggagttg ctttggagct taagagacag ttagagtcaa
    11581 acttagttat gagaagctat caaggtttct taaaataaaa tggagatgga taatatgaga
    11641 ataatattac ttggacctcc aggtgctggt aaaggtactc aggcggcagg aatagtagaa
    11701 aaatacaata tacctcatat atcaacagga gatatattca gaaagaatat aaaagaggga
    11761 acagaacttg gaaaaaaagc taaagaatac atggaccaag gtttattagt accagatgag
    11821 ttaactgtag gtttagttac tgatagaata tctcaagaag attgtaaaaa tggatttatg
    11881 ttagatggat ttccaagaaa tgtagcacaa ggagaacatt tagatatctt cttaaaaaat
    11941 gctggtatat cactagataa agttgtcaat attgaagttg ataagagtat attagtgtct
    12001 agagcagttg gtagaagaat atgtaagtct tgtggagcta cttaccatgt tgagtttaat
    12061 cctcctaaag tagaaggtgt atgtgatgta tgccaaggag aattatatca aagagctgat
    12121 gataatgaag aaactgtatc taagagaata caagtttatc tagatgaaac taagccttta
    12181 gtagattatt atagcaaaca aggtataata gcagatataa aaggtgatca agcaatagat
    12241 aaagtatttg aagatattgt cgcagcctta ggaagtggaa aataaatgat tatcttgaaa
    12301 tcaaaaaaag aaatagaact tttaagagaa gcaggtaaaa tagttgctga cactcatgaa
    12361 gttttaagaa aagctatttc tccgggaata tctactttag aattagataa aatagctgaa
    12421 gagaatataa gaaaatacaa tgcagaacct tcttttaaag gatatggagg ttttccagga
    12481 agtatatgtg cttctatcaa tagagaggta gtacatggta tcccaggaga aactatatta
    12541 caagaaggtg acattgtaag tttggatata ggagcctatt ataaaggata tcatggtgat
    12601 tctgcgaaaa ctcacggagt aggcatgata tctgaagaag ataggaaatt gatagaagta
    12661 actagagaaa gcttctatga aggaataaaa tttgctaaat taggatatag actttcagat
    12721 atctcacacg cagtacaaac acacgttgag aaacatggtt tctcggtagt tagagattta
    12781 gtgggtcatg gagttggagc aaatcttcat gaagacccac aagtacctaa ttatggactc
    12841 ccaggaaaag gaccaagact tagagaagga atggttattg ctatagagcc aatggttaat
    12901 gcaggtcgtt atcatgtaaa gactctatca gatgggtgga cgactgttac aatagatgga
    12961 aaaaaatcag ctcattatga gcatacgata gcaattactg aacatgaacc tttgatattg
    13021 acaaagttgt aatttaaaaa gtaggtgaaa aaagtgctat cagataattt aagtataggt
    13081 caagttgtta aagtttcatt aggacgagat aaaggaaatt tattctttgt agtcaaaata
    13141 attaataatg aatatgtatt aatagctgat ggaaaaaaga gaaaacttga caaacctaag
    13201 ttaaagaaag tgaagcactt aaaaaaatat aattttatta atgatgaagt tagaaaaaga
    13261 gtagtatctg gacaagagat tacagattct tttttaagag ctgaacttac taagttaaat
    13321 tagataattt aacttattga aatggagggc tggttagtta atggccaaaa aagatgttat
    13381 agaattagaa ggtacagttt cagaagcttt acctaatgct atgttcaaag ttaaactaga
    13441 aaatggacat gagatattat gccacatttc tggaaagcta agaatgaact tcataagaat
    13501 tcttgaaggt gacaaggtga atgttgaact ttctccatat gaccttacaa gaggaagaat
    13561 tacttggcgt aagaagtaga ctatattaat atttagtcta aggagggatt aataatgaag
    13621 gttagaccat cagtaaaacc aatatgtgaa aaatgtaaag taataaaaag aaaaggaaaa
    13681 gtaatggtta tctgtgaaaa tccaaagcat aagcaaaagc aaggataaga aattattact
    13741 agcattttgt taaattttat agtataatac tatattgtga tgttaacaaa agaacgttaa
    13801 aatcgttgaa caatctggcg taggattggc atatgatgtg aagttttaaa cactaaaaac
    13861 tatgtgtagg aggtgcgatc atggcaagaa tagctggggt agatttacct agagaaaaaa
    13921 gagcggagat aggcttaact tatatatatg gtataggtaa agcaactgct aacgaaatat
    13981 tagctaaggc tgagataaat ccagatacta gaataaaaga tttatcagaa gatcaagtta
    14041 atgagttaag aaaagttata gatgacgatt tcttagttga aggtgactta agaagagaaa
    14101 ttgctttaaa cataaagaga ttaagagata taaaatgtta tagaggaata agacacgcta
    14161 aaggtcttcc attaagagga caaagaacta agactaatgc tagaactaga aaaggtccta
    14221 gaaaaacagt atctcgtaaa aagaaaaaat aaataaataa taactagatg aaggagggaa
    14281 aaggaaaatg gctaaaccaa aaaagaaagt tacacgtatt agaagaagag aacgtaaaaa
    14341 tatagaacgt ggtcatgctc atatacaatc aactttcaat aatacaataa taactttaac
    14401 tgacgttcac ggaaatgcta tatcttgggc aagttctgga caattaggat tcaaaggatc
    14461 aagaaaatca actccatttg catctcaaat ggctgctgaa acagctgcaa aagctgcgat
    14521 ggaacacgga ctaaaaagtg ttgaggtatt cgtaaagggg ccaggttcag gaagagaagc
    14581 tgcaataaga gctttacaag caactggact agaagtaact atgataaaag acgttactcc
    14641 aatcccacat aacggatgca gaccaccaaa gagaagaaga gtgtaattaa taagagtaca
    14701 ataggaggtg tagataaatg gcaagatata caggtgcatc atgtagacaa tgccgtagag
    14761 agggaatgaa attattcctt aaaggtgata gatgttatac agacaaatgt gctatagtaa
    14821 aaagaaacta tgctccaggt caacatggcc aaggaagaaa gaaagtttct aactatggat
    14881 tacaattaag agaaaaacaa aaagttaaaa gaatatatgg agttttagag actcaattta
    14941 gaaatttata tgaacgtgct gaaaatatgc ctggtaaagc aggtgagaac ttattaagtt
    15001 tattagagag aagattagat aatgtagttt acagaatggg actagcatct tctagaaaag
    15061 aagctagaca attagtgact catggtcatt tcactttaaa tggaaataaa gtagacatac
    15121 cttcattaat agttaaggtt ggagatgtta tagaagttaa agagaaatca agatcttctg
    15181 caaaattcaa aaatttagta gaagttaact caagaatagc tcctaagtgg ttagaagcta
    15241 atgtagaagg aatgacagca aaagtagttg gtgttccaac aagagaagat atagatcttg
    15301 agatagcaga gcacttaatc atagaacttt actctaaata ataagcacac ttttaaaaat
    15361 tattttaaaa ttttgtttac cctcagtgga ttactgaatt ttaaggaggg ttttgtccat
    15421 gatagaaata gaaaagccaa aagtagatat agttgagctt agcgaagact atagatatgg
    15481 taagtttgtt atagagcctc tagaaagagg atatggaata actataggta acgcattaag
    15541 aagaatatta ttatcatcat taccaggtgt agcagtgaat gctataaaaa tagatggagt
    15601 tcttcatgaa ttttcaacaa tacctggtgt taaagaagat gttactgaga taatattaac
    15661 tttaaaagag ctttcagcaa ctatagatgg tgaaggaagt agaacactta aaatagaagc
    15721 tcaaggacca tgctctatca caggtgcaga tataatctgt cctccagatg ttgaaatatt
    15781 aagtaaagat ttagcaatag ctacattaga tgataatgct aaacttaata tggagatatt
    15841 tgtagataaa ggtagaggtt atgtttctgc tgaagaaaat aaaacagaga atgttccaat
    15901 aggtgtttta cctgtggatt caatatatac tcctgttgag aaggttagtt atcatgtgga
    15961 aaacacaaga gttggtcaaa aaacagatta tgataaatta gtattagaag tttggactaa
    16021 tggtagtata aatcctcaag agggaatatc attagctgca aaggtattag ttgagcattt
    16081 aaacttattt atagacttaa ctgaacatgt aagtagtgtt gaaatcatgg tagaaaaaga
    16141 agaagatcaa aaagaaaaag ttcttgaaat gactatagaa gaattagatt tatcagttag
    16201 atcatataac tgtttaaaga gagcgggaat taatacagtt gaagaattag ctaataaatc
    16261 tgaggatgat atgatgaagg ttagaaacct aggtaagaag tcattagaag aggtaataca
    16321 aaaactagaa gaacttggat tgggattaaa accaagtgaa gaatagcgag caaaggaggg
    16381 ataagaatgg ctaagtaccg taaattagga cgtgaaacag ctcacagaaa ccttatgtta
    16441 agaaacttag taacttgctt actaagaagt ggaagaatag aaactacagt gactagagcg
    16501 aaagaaactc gtagaatggc tgaaaagatg ataactcttg ctaagagagg agatcttcat
    16561 gctagaagac aagttttagc ttatgttatg gatgaaacag tagttaataa cttattcaca
    16621 gatttagctc caaaatatgc tgagagaaat ggtggataca ctagaataat aaaaataggg
    16681 ccaagaaaag gcgatgctgc tgaaatggct tttatagaat tagtatagta aggaaaggat
    16741 taggcttgat ggcttaatct tttttttatt tttttgacta aggtatgata taataatgtg
    16801 taaaatgatt tttataagtt attgcttact aaaaggagta tgagttaatg gataatatag
    16861 taaaggtaaa taatatttcg tttgagtata ttacagatga agcaaaactt aaagcaatag
    16921 ataatttaag cctagatgtt aaaaaaggag aatttgttgc gataatagga cataatggtt
    16981 ctggtaagtc tactttatct aaaaacttaa atgctattct tatgcctact gaaggaaata
    17041 ttcttattga tgatatggat actaaagaag aagaaagatt atgggatata agacaaactg
    17101 caggcatggt atttcaaaat ccagataatc aaatagttgc tactatagta gaagaagacg
    17161 ttgcatttgg acctgagaac ttaggtatag aaccaaaaga aataagacga attgtagagg
    17221 agtctttaaa aagtgtaggt atgtatgatt taagagatag acagcctcat ttgttatcag
    17281 gaggtcaaaa gcaaagagtt gcaatagcag gaattattgc tatgaggcct aaatgtataa
    17341 tatttgatga agcaacagca atgttagatc catctggaag aaaagaagtt atgaaaacaa
    17401 taaaaagact taataaggaa gaaaatataa ctgttataca tataacgcac tttatggaag
    17461 aagcagtaga agctgataga gttgtagtta tggaaaaagg aaagaaaatc ttagagggaa
    17521 ctcctagaga agtattcagt aaaataaaga tgttaaagga aatcggttta gatgtacctt
    17581 gtatgacaga gttatctagt ttattaatag aagaaggtat aaatattagt agtgatatat
    17641 taactgtgga tgagatggtg atggaattat gtcaattata gtaaagaatt taacacatat
    17701 atataatgaa gggatgcctt ttgcaagtaa ggcacttgat gatgtttctt ttgagattaa
    17761 agatagagat tttgttggtc ttataggtca tacaggctca ggaaaatcta cattaataca
    17821 acatttaaat ggattactaa agccttcctc aggagaaata tttataaatg attttaatat
    17881 aacagataaa aacttgaatt taactgagat tagaaaaaga gtaggggttg tatttcaata
    17941 tccagaatac caattgtttg aagaaacgat tgataaagat atagcttttg gaccctctaa
    18001 tttaggctta gaggagtctg agatacataa cagggtaaaa gcatcaatgg aagctgtagg
    18061 acttgattat gagggattta aagacaaatc tccttttgaa ttatctgggg gacaaaagcg
    18121 tagagtagca attgctggag ttatagccat gaacccagaa gttctcatat tggatgaacc
    18181 aactgctggt cttgaccctg gtggaagaga tgaaattttt aacttaataa aagacttaca
    18241 tgaaaaaaag aatatgacta taatactatc atcacatagt atggatgata tggcaaagtt
    18301 agcaaaaact ttaattgtta tgaatcatgg tagcgtagaa tttatgggaa ctcctagaga
    18361 agtatttaaa tcaaatgcta gtaaattaaa agatatagga ttagatattc cacaagtttt
    18421 agagcttgca ttgaaattga gagaaaaagg ctttgacatc agtgaggata tattgacttt
    18481 agaagaagca aaacaggaaa tattaaaagt tgtgagagga cgaggattat gttaaaagat
    18541 ataactatag ggcaatacta cccaacaagt tctgctattc ataaattaga tccaaggata
    18601 aagcttgtag cgacaattgt atttatggta tctatatttg tagtaaataa attttggcct
    18661 tatatagtag ttttattatg tttattagct atgataaaat tggctaatat accagtcaaa
    18721 tatattgtta agggtgttaa acctcttaaa tggattattt tgtttacatt tcttataaat
    18781 atttttttct taccaggtga tgaaatatgg tcatttggat ttttagctat tacaaaacag
    18841 ggtctaagac aagcaatttt tatggcaata agattaatat ttttagtagt tggtacatca
    18901 ttgcttactt taacaacttc accaatagaa ttaactgatg gaatagagag attgttgaat
    18961 ccatttaaga aaattggttt gccagttcat gaacttgcaa tgatgatgac aattgcttta
    19021 cgttttattc ctacattgtt agatgagaca gacaaaataa tgaaggctca gatgtctaga
    19081 ggtgcagatt ttgaaagtaa gaatcttata aatagagcaa agaatttagt accacttttg
    19141 gtacctttat ttgtaagtgc atttagaaga gctgatgaat tggctatggc catggaggcc
    19201 agatgttaca gaggtggaca taataggact aagatgagag agtctgttat atcaagaagg
    19261 gattatatgg catgtgtatt tcaggttgtt tatctgggag caattatagc tactagattt
    19321 atagcaattt aattaataag ttatagatat aatgaggtaa agtatgagaa atataaaaat
    19381 taaaatccaa tacaatggta agaattattg tggatggcaa aagcaacctg attctttagg
    19441 gatacaaggt acaattgaaa gggctatata tgatataaca aaagaagaaa ccagtcttat
    19501 agggtctggt agaactgatt caggagttca tgctattggt cagattgcaa attttaaaat
    19561 taattcaggt ataagtatag aaagtatacc aatggcacta aatgccaagt tgccaaaaga
    19621 catatcagtt atagaagcat gtgaagtaaa tgatgatttt cactccagat acagtgcaaa
    19681 aggtaaaaca tataaatatt tagtatataa tagcaagttt agaaatccaa tacttagtga
    19741 gatatcatat caagtaaaat atgaacttga ttttgataaa atgtgttcag aagcaaaaag
    19801 tttattagga acacatgatt ttaaaggttt tatgagttct ggttcatctg taaaagatac
    19861 agttagaacg atatatgata ttgatataag taaaaaagat gacttgatta cttttgagat
    19921 tagtggtaat ggttttttat ataacatggt gaggattatt gttggaacac ttgttgatat
    19981 gggtcgtggc agaattaacg aaccattttt agatataata caatcaaaaa ctaggtcaag
    20041 atgtggacat acagctccag cacaaggatt atttctcaaa aaagttcatt attaacttga
    20101 cacaccaggc tacatgtatt aaaatatatg agaatgtgtt aataagtcca cttgccccgg
    20161 acttgacata aacggtaaaa aaattttatg aaaagtagtt aaggagggac agttatgaaa
    20221 agttatatag ctaagccagc tgatgtacaa agaaaatggt acttagttga tgctgaagga
    20281 aaaacattag gtcgtttagc aacagaaatt gcgacagtat tgagaggtaa acataaacca
    20341 acatttactc ctcacgttga tggtggagat tttgttgttg tagtaaatgc agaaaaaata
    20401 gttttaagtg gtaagaaatt agatcaaaaa tattacagat accatactgg ttatgtaggt
    20461 ggattaaaag aaatatctta tagagatatg atggataaga aaccagaaga agttatatca
    20521 catgctgtaa gcggtatgtt acctaaaaat aaattaagaa gcagaatgat gactagatta
    20581 agagtatttg caggtgctga gcacactcat gcagctcaaa atccagaagt tttaaacttt
    20641 aaataagatt aataggtgaa aggaggagtt tataatggct aacgttcaat attatggaac
    20701 tggaagaaga aaaagttctg ttgctagagt aagactagtt gcaggtgaag gaaatatatt
    20761 agtaaatgga agagcattag aaaattattt taattatgag acattaataa gagatgttaa
    20821 acaaccatta gttttaactg gtaatgaaaa taaatatgat gttatagtaa aagttgaagg
    20881 tggaggattc actggacaag ctggagctat aagacatgga atatctagag ctttattaaa
    20941 agctgattta gatttaagac ctgctttaaa gaaagaaggt ttcttaacta gagatgcaag
    21001 aatgaaggaa agaaagaaat acggattaaa agcagcaaga agagctccac aattctcaaa
    21061 aagataatta cttatttttt tggaaaagca aaatccttta tttactgtta ttcagaaagt
    21121 attggtattt taaaaatgtt gggttaagtt aattattgat atataataaa ataataagat
    21181 atcttattag gatgtttttc attaagaaga acatcc
//
LOCUS       DAEHWM010000075        20802 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.076, whole genome shotgun sequence.
ACCESSION   DAEHWM010000075 DAEHWM010000000
VERSION     DAEHWM010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20802)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20802)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20802
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.076"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            17..415
                     /locus_tag="KNP36_002719"
     CDS             17..415
                     /locus_tag="KNP36_002719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874580.1"
                     /translation="MKKLDTESLEKMAKQKNIDKDKIEKMADSYKGKSENELMEELIK
                     IGKNLDGRDEVVSKFKAFLDENQRKKLDNIMEKISDAENQRDTKPAKTKKAKPTKGKS
                     NSPAPKNTPGSQQKKSKSLFKKTKKSNPHE"
     gene            complement(538..1554)
                     /gene="ccpA"
                     /locus_tag="KNP36_002720"
     CDS             complement(538..1554)
                     /gene="ccpA"
                     /locus_tag="KNP36_002720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family transcriptional regulator CcpA"
                     /protein_id="HBF0874581.1"
                     /translation="MKGNITIKDVAKQAGVSISTVSRVINDSKPVTDEVKQKVLEVIK
                     ETGYIPNPLARSLVTKKSQLIGVIVPEVSDSFVNEVLNGIEEVAKMYDYDILLANTYS
                     DKEQELKSINLLRAKQVEGIVMISWIVEQEHINYIQNCGIPATYISKTARNYDIYTVS
                     TSNEEATFDMTEHLIKKGHEKIAFIMTSKDDTVLEMERLAGYEKALSNNNIELDKSLI
                     KYGGTDYESGYNSMKELLDDGIIPHAAFVTGDEAAIGAINAICDAGYKVPEDISVAGF
                     NDVKIARMYRPKLTTVYQPLYDMGAVAIRMVIKLINKELIENKKIELPYRIVDRESVT
                     ERKK"
     gene            complement(1807..2007)
                     /locus_tag="KNP36_002721"
     CDS             complement(1807..2007)
                     /locus_tag="KNP36_002721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874582.1"
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFEDCWRDIDIMSWIPF
                     LILLLITCSCGGFFDGEVGCGC"
     gene            complement(2041..2220)
                     /locus_tag="KNP36_002722"
     CDS             complement(2041..2220)
                     /locus_tag="KNP36_002722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874583.1"
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFGDSWAEFDIMAWIPF
                     LIVLLILCCCGGCLE"
     gene            complement(2402..2608)
                     /locus_tag="KNP36_002723"
     CDS             complement(2402..2608)
                     /locus_tag="KNP36_002723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874584.1"
                     /translation="MTKLEDNMERFFGGCEGFFGNKMLIIIVIVFLLLCTDILEDLLC
                     DDNIWIWVILIVLLLFNFDDGCCC"
     gene            complement(2656..3081)
                     /locus_tag="KNP36_002724"
     CDS             complement(2656..3081)
                     /locus_tag="KNP36_002724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874585.1"
                     /translation="MKYVGLLLTSVGMFLLIAVNFYYNSITLDMQRIEDYVMETNLIL
                     EDVAEKESYVSNEKEDYISRLMHVKKGIENSKTSFLIERYKEYKIKSIESLIYTISEE
                     KKDYLDEVDRYNKLGEKEINKLINKNFLEVTYLSITTYI"
     gene            3253..3480
                     /gene="acpP"
                     /locus_tag="KNP36_002725"
     CDS             3253..3480
                     /gene="acpP"
                     /locus_tag="KNP36_002725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HBF0874586.1"
                     /translation="MFEKIKEIIAEQLGVDNLDEITMEASLMDDLEADSLDAVEIIMA
                     LEDEFGIEIPDEEAENFKCIGDICKYIEENK"
     gene            complement(3624..4628)
                     /locus_tag="KNP36_002726"
     CDS             complement(3624..4628)
                     /locus_tag="KNP36_002726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HBF0874587.1"
                     /translation="MIIHKFIIHVLDKNSDVPILNDFEGKVNQEVDGFFQKAIKRIAK
                     DEDLRKGVFKDYNDNLIKNCCEQIIYDESTFLKNSKEIASYLFDVMKINAALESCDLA
                     ICLYTIKDEKSVAILKLDYKKLYTHSIEFVDDKFNIQMVSNEIGIPETLRQKQGALIS
                     LSGINDEFHLRLLDKDAEKEGSESKFVTEFLNAKKIDDDKYKTKVFKNTAENWITNAL
                     SNDIKQAEDVRSILNYTLKEKHEVDINDFVDNSIKDDELKDSFKEHMEEKGLDESFSI
                     DKKWVEKKLKKRSIKTDNGFDIKGNLTDFEDPMKYTVKQNQDGTIDIIIKNVTFYEEK
                     "
     gene            complement(4642..5544)
                     /locus_tag="KNP36_002727"
     CDS             complement(4642..5544)
                     /locus_tag="KNP36_002727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HBF0874588.1"
                     /translation="MFKKENQRYNLISYTNEEEMTLKEVLLDKLNFSVRSLSKMKREK
                     SVLVNGVYKKPSLKVYSGDLIEVKIDEEKANFEPQDLNLQIIYDDFDIIMVNKPPFMV
                     VHPTKSHYDKTIANGISYYIDNQKENVKIRFVNRLDMNTSGLVIVAKNAYAHHTLSTA
                     MSENKVEKKYITVVDGIIKENEGTIDEPIYRPTEDSIKRIIDERGQSSVTHYKVIERL
                     ENATVLEVSLETGRTHQIRVHMAHIGHGIIGDELYGYVDEELINRQALHAYKLEFEQP
                     RTKEKLKFKADIPEDMKELISKLR"
     gene            complement(5739..6914)
                     /locus_tag="KNP36_002728"
     CDS             complement(5739..6914)
                     /locus_tag="KNP36_002728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="HBF0874589.1"
                     /translation="MREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKRANIT
                     PDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMASQLI
                     ALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMGIT
                     AENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDEY
                     IKPGTTMEKLAKLRPAFKKDGTVTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIV
                     SYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDM
                     NKVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR"
     gene            complement(7001..7846)
                     /locus_tag="KNP36_002729"
     CDS             complement(7001..7846)
                     /locus_tag="KNP36_002729"
                     /EC_number="1.1.1.157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="HBF0874590.1"
                     /translation="MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLD
                     KNLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLD
                     ELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVT
                     FDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLG
                     ANHPMGPLALGDLIGLDVVLAIMNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGF
                     YDYNK"
     gene            complement(7944..8741)
                     /locus_tag="KNP36_002730"
     CDS             complement(7944..8741)
                     /locus_tag="KNP36_002730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="HBF0874591.1"
                     /translation="MSTSDVKVYENVAVEVDGNICTVKMNRPKALNAINSKTLEELYE
                     VFVDINNDETIDVVILTGEGKAFVAGADIAYMKDLDAVAAKDFSILGAKAFGEIENSK
                     KVVIAAVNGFALGGGCELAMACDIRIASAKAKFGQPEVTLGITPGYGGTQRLTRLVGM
                     AKAKELIFTGQVIKADEAEKIGLVNRVVEPDILIEEVEKLAKIIAKNAQLAVRYSKEA
                     IQLGAQTDINTGIDIESNLFGLCFSTKDQKEGMSAFVEKREANFIKG"
     gene            complement(8760..9770)
                     /locus_tag="KNP36_002731"
     CDS             complement(8760..9770)
                     /locus_tag="KNP36_002731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit
                     alpha/FixB family protein"
                     /protein_id="HBF0874592.1"
                     /translation="MGNVLVVIEQRENVIQTVSLELLGKATEIAKDYDTKVSALLLGS
                     KVEGLIDTLAHYGADEVIVVDDEALAVYTTEPYTKAAYEAIKAADPIVVLFGATSIGR
                     DLAPRVSARIHTGLTADCTGLAVAEDTKLLLMTRPAFGGNIMATIVCKDFRPQMSTVR
                     PGVMKKNEPDETKEAVINRFKVEFNDADKLVQVVQVIKEAKKQVKIEDAKILVSAGRG
                     MGGKENLDILYELAEIIGGEVSGSRATIDAGWLDKARQVGQTGKTVRPDLYIACGISG
                     AIQHIAGMEDAEFIVAINKNPEAPIFKYADVGIVGDVHKVLPELISQLSVAKEKGEVL
                     AN"
     gene            complement(9789..10571)
                     /locus_tag="KNP36_002732"
     CDS             complement(9789..10571)
                     /locus_tag="KNP36_002732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009524639.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="electron transfer flavoprotein subunit beta/FixA
                     family protein"
                     /protein_id="HBF0874593.1"
                     /translation="MNIVVCIKQVPDTTEVKLDPNTGTLIRDGVPSIINPDDKAGLEE
                     AIKLKEEMGAHVTVITMGPPQADMALKEALAMGADRGILLTDRAFAGADTWATSSALA
                     GALKNIDFDIIIAGRQAIDGDTAQVGPQIAEHLNLPSITYAEEIKTEGEYVLVKRQFE
                     DCCHDLKVKMPCLITTLKDMNTPRYMKVGRIYDAFENDVVETWTVKDIEVDPSNLGLK
                     GSPTSVFKSFTKSVKPAGTIYNEDAKTSAGIIIDKLKEKYII"
     gene            complement(10630..11766)
                     /locus_tag="KNP36_002733"
     CDS             complement(10630..11766)
                     /locus_tag="KNP36_002733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="HBF0874594.1"
                     /translation="MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKM
                     AKAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGN
                     EEQKQKFLRPLASGEKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAI
                     AGDIYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRI
                     PKENLLGKEGQGFKIAMSTLDGGRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSK
                     FQNTQFQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKLFAAETAMEVTTKAV
                     QLHGGYGYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK"
     gene            complement(12475..12942)
                     /locus_tag="KNP36_002734"
     CDS             complement(12475..12942)
                     /locus_tag="KNP36_002734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaK/EbsC family protein"
                     /protein_id="HBF0874595.1"
                     /translation="MSISNVREYFKQFGKEDSILEFEQSSATVELAAEAAGVIPARIA
                     KTLSFKIGDDAILIVTAGDAKIDNKKYKAEFNCKAKMLTPEEVLEFTGHAIGGVCPFG
                     LKNSIKVYLDDSMKRFDTVFPACGSSNSAIELTCEEMEKFSKCEKWVDVCKNW"
     gene            complement(13021..13563)
                     /locus_tag="KNP36_002735"
     CDS             complement(13021..13563)
                     /locus_tag="KNP36_002735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874596.1"
                     /translation="MKKFIKVSFFILGIFTLFIAINKLVYRDMVSVKDYEINHLEEIV
                     FDFDSRRSRDVGTIVRFKISNNSKYSYKLNSAKMKFENCVENKKGMNKCSAYVNVDLF
                     NEKNSITERTLKYGIKPNNQGYVDFVIPKGLNFDYRYFNESGMSVEYKGEYIVNIPMA
                     KGLYLVVGKNNDTWNANIME"
     gene            complement(13615..14301)
                     /locus_tag="KNP36_002736"
     CDS             complement(13615..14301)
                     /locus_tag="KNP36_002736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBF0874597.1"
                     /translation="MFNLIRKDLIIGISSDGIRNLKYILLFFVFYFFLNSISYYTVSI
                     VVSYLIFINTFECDYENDSRIFIRSMPVSIEDIVYSKYLLGVGLIISVTIIVSLLSKL
                     TSLVFFRNMVLNDVFFSVNIFLAILTILLPLIFKFGYGKMKVCGFIVSILIYFVYGSL
                     LKMISMIVYQVKHFNYSKVGGVYLSNYVTDIANTKYINLYSMTFLTIIIFIISMYFSI
                     KISKKNKFNY"
     gene            complement(14301..15161)
                     /locus_tag="KNP36_002737"
     CDS             complement(14301..15161)
                     /locus_tag="KNP36_002737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874598.1"
                     /translation="MFSIRNITKKLGKFKLNNINLELKEGDIVGIIGPNGSGKTTLIK
                     IIMGIIDADEGEIELCNETIENSPISFKNNIGFVYDSLQFYPHLKVKEFRKIVSLFYK
                     NFDRERFDEYLNKFDIEENMHIENLSKGQSEKLMLSSALSHNAKLLILDEPTAGIDPI
                     VRTEIMQYLQDFVKNGSSSVIISTHNTDNLIKIADYLVFINRGNQIFTVKKELIEQEY
                     KIIRANKAELEAIKESIVGVKEYKYYNEALVKVGDSLKVKSLLIEIDKHKVKNPTIEE
                     LMYYYVNEVR"
     gene            15296..16096
                     /locus_tag="KNP36_002738"
     CDS             15296..16096
                     /locus_tag="KNP36_002738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+)/NADH kinase"
                     /protein_id="HBF0874599.1"
                     /translation="MKRIITINTNQLNKSLETKELLTRKLINAGFEVYSDIYPDTELI
                     ISIGGDGSFLRTVRDFDFPEIPIMGINTGHLGFFPDILPDKIDSFIEAYTKKDYIIQE
                     MSLLNAEVYTTTSGSNMLAVNEVVIRGDKSRTIHLNLSLDNKHIQNFSGDGMIISTST
                     GSTAYNYSAGGSIVDINLELMQITPLHPINTNAYRCFTSSIICSNESVIKIAPEYRFE
                     DSVLIVVDGVEHRFRQIENIKVSISDAKIKLLRMSNYEFWHRVSEKFL"
     gene            16121..16690
                     /gene="yfcE"
                     /locus_tag="KNP36_002739"
     CDS             16121..16690
                     /gene="yfcE"
                     /locus_tag="KNP36_002739"
                     /EC_number="3.1.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphodiesterase"
                     /protein_id="HBF0874600.1"
                     /translation="MKIGIMSDTHGSLLYFEKALNVLSDCDVLLHGGDVLYHGPRNDI
                     PEGYNPKKFIETLNKLENIVIVKGNCDADVDQMVIEHPIQSPYVMSQFGEIRIILNHG
                     YIESEEEIIDKAKKMGGDILVLGHTHVKKLYMDDNLIVINPGSTSIPKDGSHSVAIID
                     IIKTDDEDELELDINLIDINTGNIININD"
     gene            complement(17025..18077)
                     /locus_tag="KNP36_002740"
     CDS             complement(17025..18077)
                     /locus_tag="KNP36_002740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp18"
                     /protein_id="HBF0874601.1"
                     /translation="MKIKSKKIIAFALSLGIMLPSCVYADTISKNQNAQVDMNNYLQG
                     RKSPKEEKLIGEDRFDTAIKISQSGWNNGSERVFLVNSNSLPDALASTPLASKLDAPI
                     LLTNKNSIPYNVTEEIKRLNPAEVILIGSEGAISSSVKESLEDMEVLVSRIGGADREE
                     TSLLLTRQLDDTGDLGVSKVAVVNGYNGLADATSISSPAASDNTAIIYTGKDSIRSEA
                     KNFITQNSTKTYIVGGEYSISKKLEGQLVNSERLAGTDRKDTNAKVLEKFYGKSSKVN
                     NMYFAKDGSGREADLVDGLAAGVLASKTKSPVVLASGSLSSAQKSFIKKVKADKFVQV
                     GGGKNSKPYAEALALQ"
     gene            complement(18284..19510)
                     /gene="pepT"
                     /locus_tag="KNP36_002741"
     CDS             complement(18284..19510)
                     /gene="pepT"
                     /locus_tag="KNP36_002741"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HBF0874602.1"
                     /translation="MKQKVVERFLKYVSFDTTSNSQCENCPSSEGQRVLAKYIVEELK
                     TMGVDDVSLDENSYIMATLKGNTDGVDTIGFISHLDTIEDVSGKDIKPRIIENYDGKD
                     IVLNEALNVITYVKDSPELEEFKGDDLIVTDGTTLLGSDDKAGIAEIVTAIEYLINHP
                     EIKHGDIKIGFTPDEEIGRGADLFDVEKFGAKYAYTLDGGIVGELECENFNAANATIT
                     IHGRNVHPGSAKNKMVNAIHIAAEISEMFPADERPETTEGYEGFWHLNSIGGNVENVS
                     MAYIIRDHCKEKFENRKSIMIENIEKINKKYDNRVELDLKDSYYNMKEKIEPVMFIVD
                     IAKEAMEELGIKPRLVPVRGGTDGARLSFNGLPCPNIFTGGLNFHGKNECIPVSSMEK
                     ATKLIVRIAEKYAERV"
     gene            complement(19600..20652)
                     /gene="ytvI"
                     /locus_tag="KNP36_002742"
     CDS             complement(19600..20652)
                     /gene="ytvI"
                     /locus_tag="KNP36_002742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation integral membrane protein YtvI"
                     /protein_id="HBF0874603.1"
                     /translation="MSILENNFLYKLKNNTIFFCIYTLLFIFIYKAFPYIAPFFLGAI
                     IALMINPISQKLENKFRINKGISTLVLSFLAVAIVSTVTTIIVINSMKELMGFLNNIS
                     ANPEDISNTIMYFLNKINDFMKSFQEIANFDVEQLVNKFSGEVMQITKNLLTSILGLA
                     TSIPYIIIFIITLFIATYFIAKDLDKIENSFYNMFTVDVRKKVKNVKKEAGLSLVGYI
                     RAYTILMAITFFAIWGSFALFGLKYGLIVGFVGALMDLIPFLGIITIYLPVIVYYFLI
                     KNYFIAISMTVIFFVLSLIREILEPKLVSVNVGLNPLATLAAIFIGIQVKGIIGVIFC
                     LGLVCMHDILKKVDIF"
BASE COUNT         6755 a         3752 c         2255 g         8040 t
ORIGIN      
        1 agaaaggggt ttttttatga aaaaattaga tacagagtca ttagaaaaaa tggctaaaca
       61 aaaaaatatt gacaaggata aaatagaaaa gatggctgat agttacaaag gaaaatcaga
      121 aaatgaactt atggaggaac ttataaaaat aggtaagaac ctagatggca gagatgaagt
      181 agtatcaaaa ttcaaagcat ttttagatga aaatcaacgc aaaaaactgg ataatataat
      241 ggaaaaaatc tcagatgcag aaaaccaaag agatactaaa ccagctaaaa ctaagaaggc
      301 taaacctact aaaggtaagt caaattcacc tgcaccaaaa aatacaccag gtagtcaaca
      361 aaaaaaatct aaaagtttat ttaagaaaac taaaaagtct aaccctcatg aatagataaa
      421 aataaactat ttaagtaatt agataattat ttttagttaa tctattatta aatttgatat
      481 tattgacata aaaaatcagg tagtgcctta ggcactacct gattgatttt aatagtttta
      541 tttttttctt tctgtaacac tttctctatc aacaattcta taaggtaatt ctattttctt
      601 attctcaatt aattccttat ttattaactt tataaccatt cttattgcta ctgctcccat
      661 atcgtataga ggttgatata ctgtagtaag tttaggtcta tacattctag ctatcttaac
      721 atcattaaat cctgcaacag atatgtcttc tggaacctta tatccagcat cacatatagc
      781 atttatagca cctatggcag cctcatcacc tgttacaaaa gccgcatgag gtattattcc
      841 atcatctaat agttctttca tactattgta tccactctca taatcagttc caccatactt
      901 aatcaaactc ttgtctaatt ctatattgtt atttgaaagt gctttctcat aaccagcaag
      961 tctttccatt tctaaaacag tatcatcttt actcgtcatt ataaaagcta tcttttcatg
     1021 acctttcttt ataagatgct ctgtcatatc aaaagtagct tcttcgttgc tagtacttac
     1081 tgtatatata tcataatttc tagcagtttt acttatatat gtcgctggta ttccacaatt
     1141 ttgtatatag ttgatatgtt cttgttcaac tatccatgaa atcataacta taccttccac
     1201 ttgttttgct ctcaatagat ttatactctt aagttcttgt tccttatcag agtatgtatt
     1261 cgctaaaaga atatcatagt catacatttt agcaacctct tctatcccat ttaacacctc
     1321 attaacaaaa gaatctgaaa cttctggaac tattacccct attaattgac tcttctttgt
     1381 tactaagctt ctagcaagtg gatttggtat atatccagtc tcttttataa cctctaaaac
     1441 tttttgtttg acttcatcag ttacaggttt tgaatcattt ataactctag atacagtaga
     1501 tattgacact cctgcttgtt tagcaacatc ttttatcgtt atattgcctt tcatcttcat
     1561 cctccttatt ttactaaatt tatctaaaac tgaaccaaat ttttgaaggt tcctatttta
     1621 actacattta tataagtttt tattttacca taaaagcaag tacatttaaa tacattatat
     1681 tttatattat accctatatt caacaaattt aataatattc attcttaatt taaatcatat
     1741 taaaaaataa aataaaaaaa tgctggtata aaataccagc atttttttat tctaatgatt
     1801 taagtattag cagccgcaac ctacttcacc atcaaagaat ccaccacatg aacaagttat
     1861 tagcaataat attaagaaag gtatccatga cattatgtca atgtctctcc agcaatcttc
     1921 aaaagctaag aataggaaga atagtactat tatccaccat cctcctccac caaagcatcc
     1981 ttcttctcca aaaaatctat ctaacataac aaagccctcc tttttttaat aactgtgttc
     2041 ttattctaag catccaccac agcagcaaag tattaataaa actattagga atggtatcca
     2101 tgccattatg tcaaattctg cccagctatc tccaaaagct aagaatagga agaatagtac
     2161 tattatccac catcctcctc caccaaaaca tccttcttct ccaaagaatc tatctaacat
     2221 tatacgttac ctcctgttga tattttgttg agcttttcgc tcctaacata tactatgcat
     2281 ttggtttcca ttttgctaat gtatttttac tattttttta aattttttaa tttgaactaa
     2341 aaaaggtaaa accataactt gtataagtta ctggttttac ctatttaata atcaatattt
     2401 tttagcaaca acaaccatca tcgaagttaa ataataacaa tactattaat ataacccata
     2461 tccatatatt gtcatcgcat aataagtctt ctaaaatgtc tgtgcataat agtaagaata
     2521 ctataactat tattatcaac attttattcc caaaaaatcc ttcgcatcct ccaaagaaac
     2581 gttccatatt gtcttctaat tttgtcataa ctaatcctcc ttgaatcatt aagagactaa
     2641 gttttgtctc tttaattaaa tatatgtagt aatagacaga taagttactt ctaaaaagtt
     2701 tttattgatt agtttattta tttctttttc accaagttta ttgtatctat caacttcatc
     2761 cagataatct tttttctcct ctgatatagt atagattaaa ctttctattg attttatttt
     2821 gtactcctta tatctttcta tcaagaagga tgtttttgaa ttttctattc ctttctttac
     2881 atgcattaac cttgatatgt agtcttcttt ttcattagat acataactct ccttttcagc
     2941 tacatcttca aggattaaat tggtctccat tacataatcc tctatacgtt gcatatctaa
     3001 agttattgaa ttataataaa aatttactgc tataagtaaa aacattccta ctgaagttag
     3061 taatagtcct acatatttca tagcatttcc tcctaagtta tatttgttat caataaagtt
     3121 tattcatcaa ataatacttt attactacat ttataaaatt ttattatttt ttatagattc
     3181 catattgaaa aattcttgat attatattaa actaacatta aaattaatta aaactgcttt
     3241 aggaggctta aaatgtttga gaaaataaaa gaaataatag cagaacaatt aggggtagac
     3301 aatttagatg agataactat ggaagcatct ttaatggacg acttagaagc tgattcatta
     3361 gatgctgttg aaattataat ggcccttgaa gatgaatttg gaatagaaat accagacgag
     3421 gaagctgaga actttaaatg tattggtgat atatgtaaat atatcgaaga aaacaaatag
     3481 tatcgttttg tctacaaata taaatagtct gtgtaaactt ctacataata aattatatta
     3541 gagttcgcac agactagatt acatttattt acaatatata aaatacacgc tcttatattt
     3601 aatttatata ctaagtatat aaattacttt tcttcataaa acgtaacatt ctttattatt
     3661 atatctatag ttccatcttg attttgtttt acagtatact tcattgggtc ttcaaaatca
     3721 gttagattcc cttttatgtc aaaaccatta tccgttttta tacttctttt tttaagcttt
     3781 ttctcaaccc attttttatc tatactaaaa ctttcgtcaa gacctttttc ttccatatgc
     3841 tctttaaagc tatcctttaa ctcatcatct ttaattgaat tatcaacaaa gtcatttata
     3901 tcaacttcat gtttttcctt cagtgtataa tttaatatac ttcttacatc ttcagcttgc
     3961 tttatatcat tactaagagc attggttatc caattttcag ctgtattttt aaataccttg
     4021 gtcttgtact tatcatcatc tattttttta gcatttaaaa attctgttac aaacttagat
     4081 tctgaccctt ctttttcagc atccttatct aaaagcctta gatgaaactc atcatttata
     4141 ccacttagac taatcaaagc tccttgcttt tgtcttaaag tctctgggat accaatttca
     4201 tttgaaacca tttgaatatt aaatttatca tccacaaatt caattgaatg agtgtacaac
     4261 tttttataat ctaatttcag tattgctaca ctcttttcat ctttaatagt gtataaacaa
     4321 attgccaaat cacaagattc tagtgcagca ttaattttca taacgtcaaa caagtaagat
     4381 gcaatttctt tagaattttt caaaaaagta ctttcatcat atattatttg ttcacaacag
     4441 tttttaatta aattgtcatt ataatcttta aaaacacctt ttcttaaatc ctcatctttt
     4501 gcaattcttt ttatagcttt ctggaaaaaa ccatccactt cttgattaac tttgccttca
     4561 aagtcattta atattggaac atcactattt ttgtccaaaa catgtattat aaatttatgt
     4621 attatcatat atatcacccc attatcttaa tttcgatatt aactctttca tatcctctgg
     4681 tatatctgct ttaaatttca atttttcttt tgttcttggt tgttcaaact ctagcttata
     4741 tgcatgaagt gcttgcctat ttattagctc ttcatctaca taaccataca actcatcacc
     4801 tattattcca tgacctatat gagccatatg tactcttatt tgatgtgttc taccagtttc
     4861 taagcttact tctaatacag ttgcattttc tagtctttct attactttat agtgagtaac
     4921 agatgactgt cctctttcat ctattatcct ctttattgaa tcttctgtag gtctataaat
     4981 tggctcatct atagttccct cattttcttt tataattcca tcaactactg ttatatactt
     5041 tttttcaact ttattttcac tcattgctgt agacaaagta tgatgtgcat aagcattttt
     5101 tgctactata actaaccctg aagtattcat atctaaccta tttacaaatc ttatttttac
     5161 gttttctttt tgattatcta tatagtaact aataccattt gctattgttt tatcatagtg
     5221 gctttttgtt gggtgaacta ccataaacgg aggtttattc accataatta tatcaaaatc
     5281 atcataaatt atctgtaaat ttaaatcttg aggttcaaaa tttgcttttt cctcgtctat
     5341 ttttacttct attaaatcac cactatacac ctttaaactc ggttttttat atactccatt
     5401 tactaaaaca ctcttttccc tcttcatttt tgataatgac ctaactgaga aatttagctt
     5461 gtccaataaa acttctttta aagtcatttc ttcttcattt gtatacgata taagattata
     5521 tctttgattc tcttttttaa acaaactttt acctactttc ttttatatct tcctactttt
     5581 tatatcttca aaatcatgat attatatatt ttacactatt tttgtttaat agataataat
     5641 tatttttaac tataaaaacc tgtaagaata acaaatagtt attcttacag gttaaattca
     5701 taattaaata tttaatttgt aaatattata atctaaaact atctcttaac tattaaagta
     5761 gttcccattc ctccacctat acaaagtgta gcaagaccag ttttagcatc tcttctcttc
     5821 atttcatata aaagtgtagt aagtattctt gctcctgagc atcctattgg atgtcctata
     5881 gctattgctc caccattaac attaacttta ttcatatcta tatttaagtc tcttattaca
     5941 gctacagatt gggcagcaaa tgcctcatta gcttcaacta aatctatatc ttcaatagtc
     6001 atattagcag cttctaaagc ttttttagtt gctggaactg gtccatatcc cattatttta
     6061 gggtcaacac cagctgttcc ataagaaact atagttgcaa gaggctctat tcctagttct
     6121 tcagcttttt ctttagccat tactactagc atagcagcac catcatttat tcctgatgca
     6181 ttaccagcag taactgttcc atctttttta aatgcaggtc ttaacttagc aagtttctcc
     6241 attgtagtgc caggcttaat atattcatct ttatctacta cagtgtcacc ttttcttcct
     6301 tttataacaa caggaactat ttcttcatca aattttcctt cagcttgagc tttttcagct
     6361 ttattttgac ttgcaagagc taattcatct tgttcttctc tagttatatt ccattgctct
     6421 gctatgtttt cagcagtaat acccatgtga tagttattaa atatgtctga taatccatct
     6481 tttatcattg aatcaacaaa agcagcatca cccattcttg caccatatct cgcacttggt
     6541 actaaataag gagacatact catgttttca gctccaccaa ctaacattat atcagcatca
     6601 cctaatgcta taagttgaga tgccattgaa acagatctta atccagaacc acaaactata
     6661 tttatagtca tagctggttt ttctactggt attcctgctc ctaatgctat ttgtcttgct
     6721 atattttgtc caagacctgc tgtaagtact ccccctaaaa gagattcatc tatcatatct
     6781 ggagttatgt tagctctttt tatagcttct ttagctgctg ttacccctaa ctctaccgct
     6841 gaaactgatt taaatgctcc tccaaaactt cctactgctg ttctagctgc actggcaatt
     6901 actacttctc tcatattcat tacccccatt aaattagatt tttcatatat ccgaaattgt
     6961 tttttaaaca attttattta aacttttaat tcccaaattc ttatttatta taatcataga
     7021 atcctatctt agtttttctt cctaattgat tagctctaac cattttagct aaaagtggat
     7081 gaggtctata tttagtatct ccaaattcag tatataaaac gttcattata gctaaaacaa
     7141 catctaatcc gattaaatca cctaatgcta gtggtcccat tggatggttt gctcctaatt
     7201 tcatagcttc atctatttct tctttacttg caacaccatc tgcatatata ccaacagctt
     7261 catttatcat aggtataagt attctattta ctacaaatcc aggagattca gatacatcta
     7321 ctggtacttt attgatactc ttagataatt caaatactgt atcaaaagta acttttgatg
     7381 ttaactgacc acttataact tcaactaatt tcatcatagg aactggatta aagaaatgca
     7441 ttcctataac tttatctggt ctcttagtag aagaagctat ttctgttata gataatgatg
     7501 aagtatttgt tgccaagata gtatcttctt tacataattc atctagtaac ttgaaaacat
     7561 ctttctttat attcatgtct tctacagatg cttctattat taaatccata tcttttaaat
     7621 cttcatagtt agtagttgaa ctaacatgac ttaatatttc tgcttttgta gcttcatcca
     7681 tttttccctt agtaactaac ttagttaaat ttttatctaa taaagctaaa catttatcta
     7741 tagcaccttg agttctactc tttaaacata catcatgtcc acaacttgca aaagtttgta
     7801 caataccact tcccatagtt ccactaccta ttacagctaa tttcatagtt ataacctcct
     7861 gttattttag tatttatatt ctgttaacta gattaaaata ctatttaatc tagttaacag
     7921 caaatatatt tttaattaga tttttaccct tttataaagt tagcttctct cttttcaacg
     7981 aaagctgaca ttccttcttt ttggtcttta gttgaaaaac aaagaccaaa taaattagat
     8041 tctatatcta ttccagtatt tatatcagtt tgagcaccaa gttgtattgc ttctttagag
     8101 tatctaactg caagctgagc atttttagct attatcttag ctaatttctc aacttcttct
     8161 attaaaatgt ctggctcaac gactctattt actagcccta ttttttcagc ttcatcagct
     8221 tttataactt gacctgtaaa gattaattct tttgcttttg ccattccaac caatcttgta
     8281 agtctttgag ttcctccata tcctggagtt attccaagag ttacttctgg ctgaccaaat
     8341 ttagctttag cagatgcaat tcttatatca catgccattg caagttcaca tcctccacct
     8401 aaagcaaatc cgtttacagc agctatcact acttttttac tattttctat ttctccaaaa
     8461 gcttttgctc ctaagatact aaaatcttta gcagctacag catctaaatc tttcatgtat
     8521 gcaatatctg ctccagctac aaatgccttt ccttcccctg tcaatattac aacatcaata
     8581 gtttcatcat tattaatatc tacaaatact tcataaagtt cttctaaagt ctttgaattt
     8641 attgcattaa gggctttagg tctattcatt ttcactgtac atatatttcc atctacttca
     8701 acagctacat tctcataaac tttaacatca cttgtactca taataccctc cccaagaaat
     8761 tagttagcta aaacttcacc tttttctttt gcaacactta actgactgat aagttctgga
     8821 agcactttat gaacatctcc aactatacca acatcagcat atttaaatat tggagcttct
     8881 ggatttttat ttatagcaac tataaactca gcatcttcca taccagctat atgttgtatt
     8941 gctccagata taccacatgc tatataaagg tctggtctta cagttttacc agtttgacca
     9001 acttgtcttg ctttatctaa ccaacctgca tctatagtgg cacgagaacc agaaacttct
     9061 ccacctataa tttcagctaa ttcataaagt atgtctaagt tttcttttcc acccattcca
     9121 cgtccagcag aaactaatat cttagcatct tctattttaa cttgtttttt agcttctttt
     9181 attacttgta caacttgaac taatttatca gcatcattaa attctacctt gaaacggtta
     9241 attacagctt ctttagtttc atcaggttca tttttcttca taacccctgg tctaactgta
     9301 gacatttgag gtctgaaatc tttacaaact attgttgcca ttatatttcc accaaaggca
     9361 ggtcttgtca ttaataataa ttttgtatct tcagctactg caagacctgt acagtcagca
     9421 gtaagacctg tatgtattct agcagaaact ctaggtgcta aatctctacc tattgaagtt
     9481 gcaccaaata atacaactat agggtcagct gcttttattg cttcataagc tgcttttgta
     9541 tatggttcag ttgtatacac tgctaaagct tcatcatcta ctactattac ctcatctgca
     9601 ccatagtgtg ctaatgtatc tattaaacct tctaccttac tacctaaaag taatgcagaa
     9661 acttttgtat cataatcttt tgctatttct gtagcctttc ctagtaattc taaagaaaca
     9721 gtttgaatta cattttctct ttgttctatt actactaaaa cgttacccat tctttatccc
     9781 cccttaaatt atatgatata cttctctttt aatttatcta tgataattcc agctgatgtt
     9841 ttcgcatctt cattgtatat tgtaccagct ggtttaactg attttgtaaa tgatttaaat
     9901 acactagttg gagaaccttt aagacctaaa ttagaagggt caacttctat atcttttaca
     9961 gtccatgttt ctactacatc attttcgaaa gcatcatata ttcttccaac tttcatgtat
    10021 cttggtgtgt tcatatcttt aagagttgtt ataaggcatg gcattttaac ttttaagtca
    10081 tggcaacaat cttcaaattg tctttttact aatacatatt caccttcagt ttttatttct
    10141 tcagcatatg ttattgatgg aagatttaaa tgttcagcta tttgaggtcc aacttgtgca
    10201 gtatctccat ctatcgcctg tcttccagct attataatat caaaatctat attttttaat
    10261 gctcctgcta atgctgatga agttgcccaa gtatcagcac ctgcaaatgc tctatctgtt
    10321 aataatatac ctctatctgc acccattgct aaagcttctt ttaaagccat atctgcttga
    10381 ggaggtccca ttgttataac agttacatga gcacccattt cttcttttaa ttttatagct
    10441 tcttctaaac ctgctttatc atcagggttt attatacttg gtactccatc tctaattaaa
    10501 gtacctgtat taggatctag tttaacttct gttgtatctg gaacttgttt tatacaaacg
    10561 actatattca taaatccttc ctccatatct attttaatat cgacctattg tgtatatttt
    10621 aatatttatc tattttaata attttcctga aataaccatt ctttgaactt cactagttcc
    10681 ttcatatatt tcagttatct tagcatctct catcattctt tctactggat agtcacgagt
    10741 gtatccatat cctccatgaa gttgtacagc ttttgtagta acttccatag ctgtttcagc
    10801 tgcaaataat tttgccattg ctgcttctac tccataaggt tttcctaagt ctttatttat
    10861 agctgcttga tatacaaggt gtctagccgc ttgtacctta acttccatat cagctaattg
    10921 gaattgtgta ttttggaatt ttgataatgg tctaccaaat tgtactcttt cttttacata
    10981 tttaacagtt tcatcaagag caccttgtgc taaacctaaa gcttgtgcag ctataccaat
    11041 tctaccacca tcaagagtag acattgctat cttaaatcct tgaccttctt ttccaagtaa
    11101 attttcttta ggtattctgc aatcctcaaa tattaattca ctcgtagctg aacctcttat
    11161 acccattttc ttttctttaa ctccaaagct aaacccagga gttccttttt caactataaa
    11221 tgctgatatt cctttgttcc ccttagattt atcagtcatt gccattacta catatatgtc
    11281 accagctatt gcatttgtta taaatatttt tgagccatta agtatgtatt catccccgtc
    11341 taaaacagca gttgtttgtt ggccagacgc atctgtacca gcattaggct cagtaagacc
    11401 aaatgctcct aatttttctc cacttgctaa tggtcttaag aatttttgtt tttgttcttc
    11461 attaccatat tgatatatag gccatgagcc aagagatgta tgagctgata atataactcc
    11521 tgtagtacca caaactctag acaattcttc aactgccatt atatatccta cagtgtctcc
    11581 accttctcca ccatattctt ttggatatgg tatacccatc attcctgctt ttgccatttt
    11641 ttccactgtt tcataaggaa atctttcttc ttcatcaagt tctgttgcta aaggtttaac
    11701 ttcattttca gcgaagctta catatagctc tttaagcatc tgatattttt tagaatttaa
    11761 atccataata gcctcctcag tattttataa atattttatt ttcatttatt aattaaaatc
    11821 tcggcaacat ctataataag gtatttgaat atacgtcgag aaatttataa ccttaatcaa
    11881 actacgctct atatttatat gtgattatac taaccaatta tgacattaat ttaatcataa
    11941 attgttaatt taaaatcaac tatacttaaa aaaaatctcg ctttttggaa ttttgtgaaa
    12001 tttcaagtta gaataagatt tctttcacac tggttagaga taaaataatt tgtttacgat
    12061 atttatatta aggtatatta aacattaaat attgtctgta catctgtttt ttagccatgt
    12121 acagaagatt tttatcgtat aaaaattatt ttaatagagc taaataatca tatttttatc
    12181 tgactatttt ttatttttaa atatcttaca tctataatag tatcactcaa aggataattt
    12241 ttcaataatt tctaattatt tttttaacaa tatttattac attttttcca cttttttgtc
    12301 atttttttat tgtttcgaaa aaaaatcaga attttttaac tttattttgg attattagtt
    12361 taaattagat tttcctctta gatttataaa tatttacaca aaaaaactac ctctgtatag
    12421 attgtataca gaggtagttt tttactaatt cctactatag tttactatat ttttttacca
    12481 attcttacaa acatctaccc atttttcaca cttagaaaac ttctccattt cttcacatgt
    12541 aagttctatt gcagagttac tactgccaca tgcaggaaat actgtatcaa atcttttcat
    12601 tgaatcatct aaatagactt ttatagaatt ttttaaacca aatggacaga ctccaccaat
    12661 agcatgtcca gtaaactcca agacttcttc tggtgtcaac attttagcct tacaattaaa
    12721 ttcagcctta tacttcttat tatcaatctt agcatcacca gctgtcacaa ttaaaattgc
    12781 atcatctcct attttaaatg agagtgtctt agctattctt gctggaataa ccccagctgc
    12841 ttcagctgca agttccacag tagcactaga ttgttcaaat tctaatatac tgtcttcctt
    12901 gccaaattgt ttaaaatact ctcttacatt acttattgac attaaatacc cctcctagtc
    12961 tgaactttta taaatttcat attattctta attatatcta taattgattt atttttcaaa
    13021 ttattccata atattagcat tccatgtatc attatttttt ccaactacta gataaagtcc
    13081 ttttgccatt ggaatattga caatatattc tcctttatac tctacactca taccagattc
    13141 attaaagtac ctataatcaa aatttagtcc ttttggaatt acaaaatcaa cataaccttg
    13201 attatttggt tttattccat atttcagagt tctttcagtt atagaatttt tttcattaaa
    13261 taaatctaca tttacatatg cagaacactt attcattccc tttttatttt ccacacaatt
    13321 ttcaaacttc attttagcac tgtttaattt ataactatat ttactattat tgcttatttt
    13381 aaatcttaca atagtaccaa catctctact tctcctgcta tcaaaatcaa aaacaatttc
    13441 ctctaaatga tttatttcat aatctttgac acttaccata tctctatata ctaatttatt
    13501 tatagctatg aatagtgtaa aaatccccaa aataaaaaat gaaactttta taaacttctt
    13561 catttttagt ctccttatat tttgtgctat tgtgctataa tattaatcaa aattttaata
    13621 attaaactta ttcttttttg aaatcttaat agaaaaatac attgatatta taaaaattat
    13681 tattgttaaa aatgtcatac tatataaatt tatatactta gtattagcta tatcagttac
    13741 ataatttgaa agatatactc ctccaacttt actataatta aaatgcttta cttgatatac
    13801 aatcatacta atcatcttca aaagacttcc atatacaaag taaattaaaa tacttactat
    13861 aaaaccacaa actttcattt ttccatatcc aaacttaaaa attaaaggca gtaaaatcgt
    13921 caaaattgct aaaaatatat ttacagaaaa aaatacatca tttaaaacca tatttctaaa
    13981 gaacactagt gatgtcaatt tacttagtaa ggacacaatt attgttacag aaattattaa
    14041 tcctacacct aataaatatt ttgagtaaac tatatcttct atactaactg gcatactcct
    14101 tataaaaatc cttgaatcat tttcataatc acactcaaat gtatttataa atatcaaata
    14161 actaacaaca atacttactg tataatatga aattgaatta aggaaaaaat aaaacacaaa
    14221 aaatagcaat atgtacttta aattacggat accatctgaa ctaatcccta ttattaaatc
    14281 ttttcttatt aaattgaaca tcatctcacc tcatttacat aataatacat tagttcttct
    14341 atagtaggat ttttgacctt atgcttatca atttctatca ataggctttt tactttcaag
    14401 ctatctccaa ctttaacaag tgcctcatta taatatttat actctttcac accaactatg
    14461 ctttctttaa ttgcttctaa ctctgcttta tttgccctaa ttatcttata ttcttgttct
    14521 attaattctt tcttaacagt aaaaatctga tttcctctat ttataaaaac aagataatca
    14581 gcaattttaa ttaaattatc agtattatga gtagaaatta ttacactact acttccattt
    14641 ttcacaaaat cttgtaagta ctgcattatt tcagttctta caattgggtc tatcccagca
    14701 gttggttcat ccaaaatcaa taacttagca ttgtgactaa gtgcacttga taacataagc
    14761 ttttcagatt gacctttaga taaattttca atatgcatat tttcttctat atcaaactta
    14821 ttaaggtatt catcaaacct ttctctatca aaattcttat aaaataaaga aactattttt
    14881 ctaaattcct taacctttaa atgcggataa aattgtaaag aatcatatac aaaaccaata
    14941 ttgtttttaa agcttattgg agaattttca atagtttcat tacaaagttc aatttcacct
    15001 tcatctgcat caataatccc cattataatt tttattaaag tcgtttttcc cgaaccattt
    15061 ggtcctataa tcccaacaat atccccttcc tttaactcta agtttatatt atttaacttg
    15121 aattttccta atttttttgt gatattcctt atgctaaaca catcttcacc tcttatgcat
    15181 ttttttatac ccacctatac atattttaac acattcacta caaaggtcat ttataaattt
    15241 ataaattaag aattataaaa ctatgttata atacaaagta tgaagaggtg aatatatgaa
    15301 aagaattata actataaata caaaccaatt aaataagtcc cttgagacta aagaactctt
    15361 aactagaaaa cttatcaatg ctggctttga agtgtattca gatatttatc cagatacaga
    15421 gcttattata tcaattggtg gtgatggctc ttttttaaga acagttagag atttcgattt
    15481 tcctgaaatt cccataatgg gaataaatac aggtcatctg gggttttttc ctgatatttt
    15541 accagataag attgatagct ttattgaagc ttatacaaaa aaagattata ttattcaaga
    15601 aatgtcactt cttaatgcgg aagtatatac aactactagt ggttctaata tgcttgctgt
    15661 aaatgaggtt gttataagag gagacaagtc taggactata cacctaaatt taagccttga
    15721 taataaacat atacaaaatt ttagtggaga tggtatgatt atttctactt ccacaggttc
    15781 aacagcctat aactattctg ctggaggtag tattgttgat ataaatcttg aacttatgca
    15841 gattacacct ttacatccga taaataccaa tgcatatagg tgctttacat caagtataat
    15901 atgttcaaat gaatctgtta taaagattgc accagaatat agatttgaag attctgtatt
    15961 gattgtcgtt gatggagttg agcacagatt tagacaaatc gaaaatataa aagttagtat
    16021 atctgatgca aaaataaaat tacttagaat gtcaaactat gagttttggc atagagtatc
    16081 tgaaaaattt ttatagactg tacttaggag gatttttaat atgaaaatag gaataatgag
    16141 tgatactcat ggtagcttac tttactttga aaaagcgtta aatgtattat ctgattgtga
    16201 tgttttatta catggtggag atgtcttata tcatggacct agaaatgata ttccagaagg
    16261 atataatcct aaaaaattta ttgagacatt aaataaatta gaaaacattg tgattgtaaa
    16321 agggaactgt gatgcagatg ttgaccagat ggttatagaa catcctattc agagtcctta
    16381 tgtcatgagc caatttggtg aaattagaat tatattgaat catggttata tagaatcaga
    16441 agaagaaatt attgacaaag caaagaaaat gggtggtgac atattagttt taggacatac
    16501 tcatgtaaaa aagctataca tggatgataa tttaatagta ataaatccag gaagtacttc
    16561 tatcccaaaa gatggaagcc attctgtcgc aattatagat atcataaaaa ctgatgatga
    16621 ggatgagctt gaacttgata taaacttaat tgacatcaat actggaaata taataaatat
    16681 caatgattag taaattttta ataaaaataa aataagcttt aatttattaa actcataata
    16741 aaaacaagta aaccatttta tttctatctc aattagaagt ttaagtacaa taccttaaac
    16801 ttctaattaa atagaatctg gtttacttgt tttattatat gctatattga aatataactt
    16861 agtttactta tttcattata tattatactg aaatataact tagtttactt attttattat
    16921 atattatatt gaaacatagc ttagtttact tattttatta tatatattga agtgcaactt
    16981 ggtttacttg ctattattat atattaattt tgatttacac aatattactg taaggctaat
    17041 gcttctgcat atggtttact atttttacct ccaccaactt gtacaaattt atcagccttt
    17101 acttttttta taaaactttt ctgtgcacta cttaaacttc cacttgcaag tactacaggt
    17161 gactttgttt ttgatgctaa tactccagca gcaagcccat caactaaatc agcttctcta
    17221 ccacttccat cttttgcaaa atacatatta ttaaccttac ttgattttcc ataaaacttt
    17281 tctaaaactt tcgcattagt atcttttcta tctgtccctg ctagtctttc tgagtttact
    17341 aactgtcctt caagtttttt acttatactg tactccccac ctactatgta tgtcttagtt
    17401 gagttttgtg taataaaatt ctttgcctca cttcttatgc tatccttacc tgtatatatt
    17461 atagctgtat tatcacttgc agctgggctt gatattgaag ttgcatctgc cagtccatta
    17521 tacccattaa ccactgccac ttttgagaca cctaaatcac cagtatcatc tagctgtcta
    17581 gtaagaagta aagatgtttc ttctctatct gctccaccga ttctactgac taatacttcc
    17641 atatcttcaa gagattcttt tacacttgat gaaatagctc cttcacttcc aattaaaata
    17701 acttctgctg gattaagcct ttttatttcc tctgttacat tatatggtat actattttta
    17761 tttgtaagca gtattggtgc atccaattta cttgccaaag gagttgaagc caatgcatct
    17821 ggcaatgaat ttgagttaac tagaaacacc ctttctgaac cattattcca accactttga
    17881 gatattttta tcgctgtatc aaatctatct tcaccaataa gtttttcctc ctttggagat
    17941 tttctacctt gaagataatt gttcatatct acctgtgcat tttgattttt actaatagtg
    18001 tctgcatata cacaacttgg caacataatc ccaagtgaaa gtgcaaatgc tattattttt
    18061 ttagatttaa ttttcaatac aattccccct tttaaatgtt aatacctatt gatattcata
    18121 ctttttattg ataccctaaa ctaaaaataa ttatctttta taaaaataat tacaaaaata
    18181 gctataccat tttaagtaca acacaagctt ataatcagct tgacttataa agaatgatat
    18241 agctattata actttaaatg cttaattttt aaatactttt taactaaact ctttcagcat
    18301 atttttcagc tattcttaca attagtttag tagctttctc catagaacta actggtatac
    18361 actcattttt cccatggaag tttaatccac cagtaaatat atttggacaa ggtaatccat
    18421 taaaagataa tcttgctcca tcagtaccac ctcttacagg aactaaacgt ggttttatac
    18481 ctaattcctc catagcttct ttagctatat caactataaa cataactggc tcaatctttt
    18541 ctttcatatt gtaataagag tcttttaaat ccaattccac tctattatcg tatttcttat
    18601 ttattttttc tatattctct atcataatag attttctatt ttcaaatttt tctttacaat
    18661 ggtctctaat aatataagcc atacttacat tctcgacatt tccacctata gaatttaaat
    18721 gccaaaatcc ttcatatcct tctgttgttt ctggtctttc atctgctggg aacatttctg
    18781 atatttcagc agctatatgt atagcattta ccattttatt tttagctgaa cctggatgaa
    18841 catttctacc atgtatagta atggttgcat ttgcagcatt aaaattttca cattcaagtt
    18901 ctccaactat tcctccatct aaagtatatg catattttgc tccaaatttt tcaacatcaa
    18961 ataaatcagc acctctacca atttcttcat ctggtgtaaa tcctattttt atatctccat
    19021 gcttaatttc tggatgattt attagatact ctattgcagt cactatctca gctataccag
    19081 ctttatcatc agacccaagt agagttgttc catcagtgac tattaaatcg tcacctttaa
    19141 attcttccaa ctctggagaa tcctttacat acgtaataac atttaacgct tcatttaaaa
    19201 ctatgtcttt tccatcataa ttttctatta ttcttggttt aatatctttt ccactaacat
    19261 cttcaattgt atctaaatgt gatatgaatc ctatagtatc cacaccatca gtatttcctt
    19321 ttaaagtagc cattatataa ctattttcat ctaaactcac atcatcaaca cccattgttt
    19381 ttagctcttc aactatatac ttagctaaaa ctctttgacc ttctgaagat ggacagttct
    19441 cacactgaga attagatgtt gtatcaaatg atacatattt taaaaatctt tccactactt
    19501 tttgtttcac gtatataccc tctttcttaa taagattaat atttttttat ttacctgtga
    19561 ataaaatttt atttttaaaa aatctatcaa ttattataat taaaaaatat ccaccttctt
    19621 aagtatatca tgcatacata ccaaacccaa acaaaaaatt actccaatta ttccttttac
    19681 ttggattcca ataaaaatcg ctgctagggt agctaatgga tttagtccaa catttactga
    19741 tactagttta ggttcaagta tttctctaat caaagacaaa acaaaaaata tcacagtcat
    19801 acttatagct ataaaataat tttttataag gaaataataa acaattactg gaagatatat
    19861 tgttattata cctaggaatg gaattaaatc cattaaagct cctacaaacc ctactattag
    19921 accgtatttc aatccaaata aagcaaaact tccccagatt gcaaaaaatg ttatagccat
    19981 aagtattgta taggccctta tatatccaac aagtgaaagc cctgcctctt tctttacgtt
    20041 ttttaccttc tttctaacat caacagtaaa catattataa aaactatttt caatcttatc
    20101 aaggtctttt gctataaagt acgtagcaat aaacaaggta attataaata ttataatata
    20161 tggaatagaa gtagccaatc caagtatact agtaagaaga ttttttgtaa tttgcattac
    20221 ttcaccactg aatttgttta ctaattgttc tacatcaaaa ttggctattt cttgaaatga
    20281 tttcataaag tcatttattt tatttaaaaa atacataata gtattactta tatcctcagg
    20341 attagcagat atattattta aaaatcccat taattctttc attgaattta ttactattat
    20401 tgtagtaact gtactgacta tagccactgc aagaaaactt agaacaagag tagagatacc
    20461 tttatttata cgaaacttat tttctaactt ttgtgatata ggattaatca taagtgctat
    20521 tatagcacct agaaaaaatg gagctatgta tggaaacgct ttgtaaataa aaataaataa
    20581 caatgtatat atacaaaaaa agatagtgtt gttttttaat ttgtataaaa aattattttc
    20641 tagtatgctc atcttaaaaa tctcctttct tctaatttat atttttattt tgtccatttc
    20701 atactagttt tatttgaata caaaataaaa agaagtgtat aaatataaaa gatatctttt
    20761 atatttatac acttctaata aatttaagaa cattattaca tt
//
LOCUS       DAEHWM010000076        20705 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.077, whole genome shotgun sequence.
ACCESSION   DAEHWM010000076 DAEHWM010000000
VERSION     DAEHWM010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20705)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20705)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20705
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.077"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            49..1863
                     /locus_tag="KNP36_002743"
     CDS             49..1863
                     /locus_tag="KNP36_002743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0874604.1"
                     /translation="MTLKYKCYDMPLNTTLNYNQSTGAYEGTINYNQDPEYLNVWELQ
                     GITINSKNNPKTLNRQDLEKLGLNLKDYNVTQECIIEDITSRKDVNKYLRKTSSPITE
                     LTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPILLVEKNNV
                     PNSVKSELKRLNPKDIIIIGDENAISKTTANQIKSTVNASQTRLNGSNRYETSLLIAK
                     EIDKNHDVEKVYITNANGGEVDALTIAAKAGQDKQPIILTDKDSITDNTYKWLKSEDL
                     QNAYFIGGPQMISTNVINKVNGITKDSVTNNRVYGADRHETNANVIKKFYTDDELEAV
                     LVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKDNLEAKSANKVYKIGGGLTS
                     KVMSSIASSLSKHNTTPTEPGNSGGKTVMIDPGHGGSAPGNSSGGMIEKDYNLNTSLA
                     TTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSLKPDLFTSIHYNGSTNKQGHGVEVF
                     YKLKDKNGGTTKTVATNILNRILEKFKLTNRGIKTRVLPSDSTKDYLYVLRSNDMPAV
                     LVECAFLDNENDMSLINSSAKVKEMGTQIGKGIEDSLK"
     gene            2105..4018
                     /locus_tag="KNP36_002744"
     CDS             2105..4018
                     /locus_tag="KNP36_002744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874605.1"
                     /translation="MEYLFEKSSLKEYGNEALDKYRELLDKTGNNSRCILLLVPNNNT
                     KIRYERSLRLNYSEELKITTYISFVKKELVKYWPLIIEKCDEISTKVVSPTFISNSLS
                     EYLIVQKVKEKRIQEGYFEDITGTNKSIANSIMTNINKSAFNLIDFDFIGEKIYSSKK
                     NKDSIYRFSYTQMDEIISYYINSLLSNSILDNALSIYLYNQYLLNDDFYLKNLFTEVR
                     YIIVDSLESSSNAEVDFITEALDNTLQSYIYFDYSRDYSVFNNVDIDYINEKIISKIK
                     PKEENIKKKEIRIEDLYLLPANIELNQSSQLYNEMLDLISEKVISLIEEDVSPRDIAI
                     ISPINNSILEHQIRDSLIEKNIDVFSTKKDKKAVDYPYGNALVVATCIFYGYLDFIKD
                     DEYLSFLETLLEINRIKAFKIFNETRHLSIDNIDEHSQYREILQYIEEKKKSDIKIHE
                     FLTQFYIDKMLNLKEGKKNVGLCKKIIAESESFSESLSLLGMKKEKIFIEALKSTIND
                     YYSVVDIEELKSKDKIVITTPYSYISSNIDRSIQIWVDIGSNAWNMKIEKDISNLIVL
                     RKSFEEKKIYTNEMEEYYKKYYLYNTVYNLLLNAKKIYAFKSEYAINGYIQESILYSI
                     LLKISHKGDKNYD"
     gene            4011..6230
                     /locus_tag="KNP36_002745"
     CDS             4011..6230
                     /locus_tag="KNP36_002745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent helicase"
                     /protein_id="HBF0874606.1"
                     /translation="MININYREDQIPIINYDNGTMAVPAVPGAGKTFIITNLVAKLLL
                     EQKHKGGKILILTYMNSAVNNFKGRIRKILEENKIDDTNSYEVMTIHSLAVKIIKEKP
                     EVVMLSEDFNIADDLQKSIILNECISRFRFEGGERAFRWFLKEQKDERWKEITLEAWE
                     RGFFEFAGNAISELKYKGISPDNLEEILSRGHKGMLKIILPIYKLYDRKLKQNGLLDY
                     DDILILAEKTLSLDEGLRKKFQTRYKYIFEDECQDSNEIQGNIIKIISSENKNLVRVG
                     DINQSITGTFSSSDPKFFKEFINSADFCYRMDMSNRSSKDILDLANTLVKYVTKEFRQ
                     KECRHALEDMQIKTVPNGMGYKENPNPEHYNINVKWYESWKIEIEQTARYVKGIKNKY
                     PDKSIGILVPFNEQVTQVAKELRENNLTFEELGPNSLNKRKVINNIAYIIDFMLHCDD
                     VEKLIVVLNKVFIDTDNEEEIKYFLEELKNYSTEEIIYNFEFSKLDNDLIEFKEESDI
                     YLSFKRGIDIIKQILEYPIIRLDLLVLFIGKKLNLEKEDKAVLDYISFYIKYLVSENI
                     NMDLEDVYNLLFDVKNRVFNHIIDVVYEINGYEPEPGSITLCNYHKSKGMEWDCVFLL
                     GLVEYNFPDNINQKFQSDKWYLKEKYKNPMAIIKSEVEAILKGSISTDYAHKTKIDSI
                     NEKIRLLYVGITRAKEMLVLSGSAYRDESDIGNKRKEQKPCIYLSRLNQHIIEKRSN"
     gene            6339..7169
                     /locus_tag="KNP36_002746"
     CDS             6339..7169
                     /locus_tag="KNP36_002746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="HBF0874607.1"
                     /translation="MNDKLKYFSYSQNSINTYKSCPLKFKYKYIDRINWKNDDVGSRE
                     YYETLKTGRDFHLICERYFSNIPLGIYFNEDDKNSKKFLKWMENIKKVVPIEKGKTYL
                     PEYEVRMTLNGDIIQAKYDLVVIGNNNIEIWDWKTESKKIDYKHVENRIQTIVYMFLA
                     KEVIPKVLKMDINVKDINMRYYQPEFDDLPITILYDEEKHEANRNKIQNYISMIKNTN
                     YEEHTYEDNLYNDIEKVYNKEERMCYRNKKHCKYCEFNKLCNGKEIDYSILEAEIYGT
                     "
     gene            7159..10626
                     /gene="addB"
                     /locus_tag="KNP36_002747"
     CDS             7159..10626
                     /gene="addB"
                     /locus_tag="KNP36_002747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddB"
                     /protein_id="HBF0874608.1"
                     /translation="MGLRFVLGRSGSGKSTYILDEIKKEAQKNETTSIILLVPEQYTF
                     EAENRVSKLFLGKEKDKYLRVRVLSFKTLSNIVFSQVGGLTDVNINSSGKAMMVYRAI
                     EDVSEELNVFSKSKSQSGFVSSITDMISEMKQYNISPEMLENISGELDNETLSLKLKD
                     ISKIYNSFEGKLHENYVDAQDMLTSLASKIELSSYLDGACVYIDEFTGFTPNQYNVIK
                     SILNKSKSVNISLTVDDINYIGYSKSDMFSRTKFTYSKLTQLCNEEGIKILPQVNLNT
                     GVIKRFEKVKELQHLERFYNAYPYKIYSNPTENIKIKEFNNLYSEVEEIAREIVHLVR
                     DKNVRYRDITIATRDLNRYDFLVHSIFNEYNIPNFIDKKREAKSNPIVILIISALEMK
                     NRRYGYETMFRYLKSGLIGIDNDDINLLENYVLANGIKGKKWFDEKWDYRITQSLSGQ
                     ESEFELELKEKINEIKNRVLEPIVILQEKLRGKNRVKEICRYIYEFLLDINMPETIES
                     LIVNFKDKGELDVANQYSQVWDIVVDILDQMVELMGDEIISLEKFIKLITLGFDEYEL
                     GLVPPSIDQVLVSSVDRMKNPDTKYLYLVGTTDGVFPLITKDSGILSDNDRESLGNKG
                     IEVDIDSKTRSFEEQFLVYKALTSTSKNLTITYPISDHEGKTLRPSIIISRLKKIFPN
                     IENKSYLVEENKSTDKDILKKITVKSPTFNELINVIKNYDSDGYNTEEINSIWLDIYR
                     YYLKDEIYSSITKKVIKGLSYTNQVHKIEEKKIRSLYKSNSLSISRLEKYAECPFAYF
                     IQYGLKAKKRKEYSFTPPDLGTFIHNILDRFSKELLQDNLTWRDIDEKYIELKIGIIV
                     DEIILKIPGYILNSSERYKYLAYRLKNMLTTAITIISQQIKQGSFEPIDYEVKFGNNG
                     KYPPIKMVLENGQEVSLIGQIDRVDEFEEGENKYIRIIDYKSGNKSISLTEIYYGLQL
                     QLLVYLDAILESAKDEDININPAAILYCRINNPIAKFNEDKDDEEIQEAILKELRMKG
                     LVVKDSHIVKEMDKSLIDGERKNSLVIPVGLTKDGNVGKSTSAISYEDFKLLRKYVRH
                     AIKDLCEEMLSGEIRIAPYKHKDGTSCDFCDYSAICQFDSTIKDNKYKNLNNKSNEEI
                     IKMMKGDVN"
     gene            10626..14453
                     /gene="addA"
                     /locus_tag="KNP36_002748"
     CDS             10626..14453
                     /gene="addA"
                     /locus_tag="KNP36_002748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HBF0874609.1"
                     /translation="MSSPKWTKEQLEVIESRECNLLVAAAAGSGKTAVLVERIIQMIT
                     SRENPIDIDKLLVVTFTNAAASEMRERIGDAIGKALDENPENKHLQNQLVLLNKSSIT
                     TIHSFCLDVIKSNFHRINLDPNFRIGDQTECAILKQEAIEEVFEDLYEERDEGFLNLV
                     ESYAERGGDKEVQDIILGIYSFAMASPEPKKWLIDSAERFNIDENFDFSQSIWARAIL
                     DTVKIEINGLCLNMERALKEVESIEELETFAEKLSVEYKKIADISQACNKSWDEAYKK
                     MASMSFENYVKGVKRISKDAPSYIKESKEKAKTIRDKTKKSLESIVSATFNKDNDSIR
                     EEIKYLYNIVKPISSVVLRFEEEYSNKKREKGIIDFNDIEHFALNILTDVDEKGNIVP
                     SDIAVGCRNKFYEIFIDEYQDSNLVQEVLLKAVANTETPNRFMVGDVKQSIYRFRQAK
                     PELFLQKYNNYNDKKGSSHRKIMLYKNFRSREEVVDAVNYIFENIMNENIGEIEYTEK
                     ERLNLGANFNVDTDEKSIIGGATEIHLIQKDNKLDDDIINDKDDRINNKENEIEEEEK
                     LDNIQLEARMVGNIIKDLMKVNEDGKIQKVYDKGIDGYRPVEFRDIVILLRATSAWAP
                     VFADELMNMDIPTYADVGVGYFDTIEIKTILSLLQIIDNPMQDIPLISVLKSPIFGFT
                     PEDLIDIRVQSKDKIFYEVLKSTAEYDGFTDSQNENESEFIPSEECINKSKDFLIKLK
                     EFKEKSMYMSTDEFIWYLYTRTGYYAYVGALPGGSQRQANLKVLFERAKQFEETSLKG
                     IFNFVNFIEKLKKSSSDMGSAKTLGENANVVRIMSIHKSKGLEFPVVICSAMGKNFNT
                     QDFKKSILYHHNLGYGPQFVDYERRISFPSIAKEALKSKINIENLSEEMRVLYVAFTR
                     AKEKLIITGSTRNIQDSIKRWSNGIESLDTISQYEILKGKNFLDWIMPCVLRHRDLSN
                     LLEEVGLDAVFNVEHNSKWYGKLWNKNDILVEKKSDEEKESIEEILEKIDVNNPDSDY
                     YGEIEEKLNYIYPYEFSTRKPATISVTEIKKIQNNYEEELINTIFEQKVILKKPLFIQ
                     NEEEREKISGTERGTIVHLVMEVLDLKNVSSVNDIKSQIRGFVSKGIITEKQASIVNP
                     YKIYKFFASNIGKRMLNAEIINREKSIYAQVNMKDIYIYEKLINNDDKKLYDNESVML
                     RGIVDAYFEEDNQIVLVDYKTDFVNEENINQIIEKYKKQLDLYADIIETLTGKSVKEK
                     CIYLFGVDEAVCY"
     gene            14499..15710
                     /locus_tag="KNP36_002749"
     CDS             14499..15710
                     /locus_tag="KNP36_002749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease SbcCD subunit D"
                     /protein_id="HBF0874610.1"
                     /translation="MRFIHTSDWHLGKSLEGHSRIEEQAKFCEEFIKIVESNEIDMVI
                     IAGDVYDTSNPPAQAEKLFYQTVSRLANNGQRCVLIISGNHDNPERLSAITPLAHEQG
                     ILIYGYPLSATIEAKYKGFEITYATQGCTKLNINGENIVVATLPYPSEKRLNEVFSSE
                     DEFEKQKNYSEKVGDIFRSLEENFRSDTINIAVSHIFVIGGESTESERPIQLGGSFLV
                     ERKDLPEKAQYTALGHLHKQQKASERLNAYYSGSPLQYSKDERAYTKGAYIVDIKAGE
                     KPIIEDVYFNNYKPIEVFKCNGIEEALDICEQNQDREIWSYFEINTDEIISQNEIKKM
                     KELLKDIIEIKPIITSCYEQESVDIKEKSMAELFREFYSFSKGVEPKGELMDLFLDII
                     SEEGESADETN"
     gene            15697..19224
                     /locus_tag="KNP36_002750"
     CDS             15697..19224
                     /locus_tag="KNP36_002750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0874611.1"
                     /translation="MRPIRLELTGLNSYIDKQVIDFEKLIERGLFGIFGTTGSGKSTI
                     LDAITIAMYGNISRNTKEYINSVCDKAIISYEFEIGSKNTRRRYIVDRTIARSKTGTK
                     TSNARLIEVLNDNTQNVLADKVVEVNEKVAQVVGLTANDFTRSVVLPQDKFNEFLRLS
                     RADRRDMLERIFNLEKYGRSLGEKVKKRKNIQLQNLKDLKSKLSQYDGITEEVYNNIN
                     QELIELKNLEKDKDNALDLAQKSYEESKTVYEEQLKLEKNELRKNELDLKNSEIKEKI
                     ALVENDSNAKKVDPYISSVQNLEKKIDEDSFAVSNLEKKLAILNQELEVTKNRYEKIN
                     KIKNEEVPKLSEEKIRLQQAIKLEEELVLLDRELKELKESGINLNKTKVELEKVKQVS
                     ESRKDAVTKSIKEVEGKIDKVNISAELKQKIFLAYEYEKDYNNVLEEKNQKLNKLEEI
                     LKETENINLKVRYIDKDKNDVNRNLENLSLHLDVLLKKCPGKSADLLLKSEYVTELRN
                     KANNTKENEIKKSSIQDELKIILESKFNTEREVNLLNEKLENNRKNRDDLEKELEELK
                     YLNLASELRRELKENMPCPVCGSKHHENHDITKYDENISFVKEKLEKLEKEKISIRNN
                     IEELNAKVSGYLSIEKMKTKELEDVKGKLGGIPSSQLLKKLDEEQRKLALLKSNIQEW
                     EKEKESTENKVTLAKEEKNKIEKEELKIRESLNNYKKLTRDLNIEIEGLENKCKKLKQ
                     EYLGLKTITKVSNLLSKVKEIRENEKELELLSTGHSNLLKNRDSLDIKIRENESKLHE
                     IEIELIKARELYVEKKLSRDNKYKEVISITKGDLAKNLLHNVEENICKILEQEESSKK
                     KLEEQRLEYEKNIAEKHNIDGRLKTAKEQYKDQKSTLNKLLAENKFESIYAVKRALLD
                     TDAVKKLIEEILEHEEEQKLLSFKIKSSKEKLNGRSIKKEYFEQLKDEIYNLKVEIGN
                     ISKDIGANQNQLITLKDSLDKINDFNKQLKVVEHNVDLLEELDKCVQGNKFVEYVSTN
                     QLKYIALEASKRLDGITKGRYALEIDSTLNFVMRDNFNGGERRSIDTLSGGETFLTSL
                     SLALALSSQIQLKGSAPLEFFFLDEGFGSLDSELLEIVIESLERLHSNNLSVGIISHV
                     EELKNRVPVKLLVSSSEAGIGSKVKIEYS"
     gene            19355..20605
                     /locus_tag="KNP36_002751"
                     /pseudo
     CDS             19355..20605
                     /locus_tag="KNP36_002751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418863.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
BASE COUNT         8990 a         1961 c         3676 g         6078 t
ORIGIN      
        1 aaatcaaaag ttagtgtcaa atttaaagaa aaaccagatg cagatagcat tacattaaag
       61 tataaatgct atgacatgcc attgaataca actctaaatt acaatcaatc aactggggca
      121 tatgaaggaa ctatcaatta taaccaagac ccagaatatc taaatgtttg ggaactacaa
      181 gggataacaa taaacagcaa aaataatcct aaaactttaa acagacaaga cctagaaaag
      241 ctgggattaa atttaaaaga ctataatgta acacaggaat gtataattga agatataact
      301 tctagaaaag atgtaaataa atatttgaga aaaacttctt cacctattac agaacttaca
      361 ggaagtgata gatatgaaac agcagttaaa ataagtaaag agggctggaa aaatggttca
      421 gataaggtag ttataataaa tggggatgta agtatagatg gcattatatc aactccactg
      481 gcaaccacat ataatgcacc aatacttttg gttgaaaaaa acaatgtacc taatagtgta
      541 aaatcagaat taaagcgcct aaaccctaaa gatataatta taattggaga tgagaatgct
      601 atttctaaaa ctactgctaa tcaaattaaa tcaactgtaa atgctagtca aacacgttta
      661 aatggttcta atagatatga gacatcttta ttgatagcaa aggaaataga taaaaatcat
      721 gatgtggaaa aagtatacat aacaaatgct aatggcggag aagtggatgc acttactata
      781 gcagcaaaag caggtcaaga caagcaacca attatattaa ctgataaaga tagtattaca
      841 gacaatacat ataaatggtt aaagagtgag gatttacaaa atgcttattt tataggtggt
      901 cctcaaatga tatcaacaaa tgttataaat aaggtaaatg gaataactaa agatagtgtt
      961 actaataata gagtatacgg agcagataga cacgaaacaa atgcaaacgt aataaaaaaa
     1021 ttctatacag atgatgagtt agaggctgtt ttagtagcta aatcagatgt acttgttgat
     1081 gctttagcag caggtccatt ggctgcgaac ctaaagtctc caatacttat aacaccaaag
     1141 acgtatgtat ctgcatacca taaagataat ttagaagcta aatcagctaa taaggtatac
     1201 aaaataggag gaggattgac ttctaaggta atgagctcta tagcatcatc attatctaaa
     1261 cacaatacga ctccaacaga accaggaaat agtgggggca agacagttat gattgaccca
     1321 gggcatggtg gttcagcacc tggaaattca tctggaggaa tgattgaaaa agattacaat
     1381 ttaaatactt cacttgcaac aactgaatat ttacgttcaa agggattcaa tgtaataatg
     1441 acaagagaca cagataagac tttatctctt ggaaatagaa ctgctctatc taattcattg
     1501 aaaccagatt tatttacaag tatacattat aatggctcaa ctaataaaca aggtcatggt
     1561 gtagaagtat tttataagct taaagataaa aatggaggga ctactaaaac tgtagctacc
     1621 aatatattaa atagaatttt agagaaattt aaacttacaa atagaggtat aaaaacaaga
     1681 gtacttccta gtgattctac aaaagattat ttatacgttt taagaagtaa tgatatgcca
     1741 gctgtacttg tagaatgtgc atttttggat aatgaaaatg atatgagttt aataaactca
     1801 tctgcaaaag taaaagaaat gggtacacaa ataggtaaag gaatagaaga ttcattaaaa
     1861 taaatggaaa taaaaatatt taaaaactta atgtaaattt atagttgtaa atttatacta
     1921 aagtcaaaaa atgaaatata agtgtatcaa tagtaagact gtatgtacat ttgcacgtgt
     1981 gaatgcaagt atatatacag tctttttttg tagttaaatg caataatttg aatgtgtttt
     2041 gtaaaataca caatatgata taattagata atatacactt aatttaattg aggaaggtga
     2101 ttatatggaa tatttatttg aaaaaagtag tttaaaagaa tatggaaatg aagctttaga
     2161 taaatataga gaattattag ataaaactgg taataattca aggtgtattc ttttgttagt
     2221 accaaacaat aacacaaaga tacgatatga aaggtctcta agattaaatt atagtgaaga
     2281 actgaaaata acaacatata taagttttgt gaagaaagaa ttagttaaat actggccact
     2341 aataatagaa aaatgtgatg aaataagtac aaaggttgta tctccaacat ttatatcaaa
     2401 tagtttaagt gaatatttaa tagtgcaaaa agttaaggaa aaaaggatac aagaaggata
     2461 ttttgaagat attacaggaa ccaataaatc catagcaaat agtataatga ctaacataaa
     2521 taagtctgca tttaatttaa ttgattttga ttttattgga gaaaaaatat attcatcaaa
     2581 gaaaaataaa gatagtatat atagattttc atacactcaa atggatgaaa ttatatcata
     2641 ttatataaat tccttactat caaattcaat tttagataat gcattaagca tatatttata
     2701 caatcaatac ctacttaatg atgattttta tttaaaaaac ttatttacag aagtgagata
     2761 tataattgtg gatagccttg aaagctcaag taatgcagaa gttgatttta taacagaagc
     2821 attggataat acattacaaa gttatatata ttttgattat agtagggatt attctgtatt
     2881 taataatgtg gatatagact atataaatga gaaaataata tcaaaaatta agcctaaaga
     2941 agaaaatatt aaaaagaagg agattagaat agaagattta tacttattac ctgcaaatat
     3001 agaattaaat caatcaagtc aattatataa tgaaatgtta gatttaataa gtgaaaaagt
     3061 tatatctctt atagaagaag atgtatctcc aagagatata gcaattatat ctcctataaa
     3121 caatagtata ttggagcatc aaattagaga ttctttgata gaaaaaaata tagatgtttt
     3181 tagtactaag aaggataaaa aagctgtgga ttatccatat gggaatgcat tggtagtggc
     3241 tacatgtata ttttatggat atttagattt tataaaagat gatgaatact taagcttttt
     3301 agaaactctt ttagaaataa ataggataaa agcatttaag atttttaatg aaacaagaca
     3361 tttaagtatt gataatatag atgaacatag tcagtatcgt gagattttac agtatattga
     3421 agaaaaaaag aagagtgata taaaaataca tgaattttta actcaatttt acatagataa
     3481 aatgttaaat ttaaaagaag gtaaaaagaa tgttgggtta tgtaaaaaga taatagctga
     3541 aagtgagtct tttagtgaaa gtttaagtct acttgggatg aaaaaagaaa agatatttat
     3601 agaagcttta aaaagtacaa taaacgatta ttactctgtt gtcgatatag aagagttgaa
     3661 atccaaagac aaaatagtaa taactactcc ttattcatat atatcatcaa atatagatag
     3721 aagtatacaa atatgggtag atataggaag taatgcttgg aatatgaaaa tagaaaaaga
     3781 tataagtaat ttaattgtac ttagaaaatc ttttgaagaa aaaaagattt atacaaatga
     3841 aatggaagaa tattataaaa aatactatct atacaataca gtatataatt tgttattaaa
     3901 tgcaaagaaa atctatgcat ttaaaagtga atatgcgatt aatggttata tccaagagag
     3961 tatattatat agtatacttt taaaaatctc acataaagga gataaaaatt atgattaata
     4021 taaattatag agaagaccag ataccaataa taaattacga taatggtact atggcagtac
     4081 cagcagtacc aggtgctgga aaaacattta taataacaaa tttagtagct aaactattac
     4141 ttgagcagaa acataagggt ggtaaaatat taattcttac atatatgaat agtgctgtaa
     4201 ataattttaa aggtagaata agaaaaattc ttgaagagaa taaaatagat gatactaatt
     4261 cgtatgaagt aatgactata cacagtttgg ctgtaaaaat aataaaggaa aagccagaag
     4321 ttgtaatgtt aagtgaggat tttaacatag ctgacgattt gcaaaaaagt attatattaa
     4381 atgaatgtat aagtagattt agatttgaag gtggagaaag agcttttaga tggtttttaa
     4441 aggagcaaaa agatgaacgc tggaaagaaa taactcttga agcctgggaa agaggttttt
     4501 ttgaatttgc aggaaatgca ataagtgaac ttaagtataa gggaatttct ccagataacc
     4561 ttgaagaaat attgtcaaga ggacacaaag gaatgcttaa aattatttta ccaatatata
     4621 aattgtatga tagaaaatta aagcaaaatg gattgctaga ttatgatgat atattaattt
     4681 tagcagaaaa aactttaagc ttagacgaag ggcttagaaa gaagtttcaa actagataca
     4741 aatatatatt tgaagatgag tgtcaggact caaatgaaat tcaaggtaat ataataaaaa
     4801 ttatatctag cgaaaataaa aacctagtta gagttggaga tataaatcag agtataacag
     4861 gaacattttc atcatcagac cctaaatttt ttaaagaatt tataaatagt gcagatttct
     4921 gttataggat ggatatgtca aatcgaagtt caaaagatat acttgattta gcaaacactc
     4981 ttgtcaagta tgttacaaag gaatttagac agaaagaatg tagacatgct cttgaagata
     5041 tgcaaataaa aactgtgcca aatggaatgg gatataaaga aaatcctaat ccagaacatt
     5101 ataatataaa tgtaaagtgg tatgagagtt ggaaaattga aatagagcaa actgctagat
     5161 atgttaaagg tataaaaaat aaatatccag ataaaagtat aggtatattg gttccattta
     5221 atgaacaagt gacacaagtt gctaaagaac ttagagagaa taatctaact tttgaagaat
     5281 taggaccaaa ttctttgaat aaaaggaagg ttataaacaa catagcatat attattgatt
     5341 ttatgttaca ttgtgatgat gtagaaaagt taatagttgt acttaataaa gtttttatag
     5401 atactgataa tgaagaagaa ataaagtatt ttttagaaga attaaaaaac tattctactg
     5461 aagaaattat ttataatttt gaatttagta agttagataa tgatttaata gaatttaaag
     5521 aagaaagtga catatattta agttttaaaa gaggaataga tattataaaa cagatattag
     5581 aatatccaat aataaggtta gacctcttag ttttgtttat tgggaaaaaa cttaatttag
     5641 aaaaagaaga taaagctgta ctggattata tatcttttta tataaagtat ctagtatcag
     5701 aaaatataaa tatggattta gaagatgtat ataatttatt gtttgatgta aagaacaggg
     5761 tgtttaatca tataatagat gtggtatatg agataaatgg atatgaacca gagcccggta
     5821 gtataacact atgtaactat cataaatcaa aggggatgga atgggattgt gtgtttttac
     5881 taggtcttgt tgaatataat ttccctgaca atattaatca aaagtttcag agtgataaat
     5941 ggtatctaaa agaaaaatat aaaaacccta tggcaattat taaatcagaa gttgaagcta
     6001 tattaaaagg aagtatttca acagattatg ctcataaaac gaagattgat tctataaatg
     6061 aaaagattag acttttatat gtagggatta ctagagcaaa ggaaatgtta gtactttcag
     6121 gaagtgctta tagagatgaa agtgatatag ggaataagag aaaagagcaa aaaccatgta
     6181 tatatttaag cagacttaat caacatatta ttgaaaaaag gtcaaattaa tatataataa
     6241 gttattaaaa gattgcttga aatatatcta aaaggggata aaacaatatg tacagtaagt
     6301 aactactaaa aaataaagtt aagagagaag tgatatgagt gaacgataaa ttaaaatatt
     6361 tttcttatag tcaaaattca attaacacat ataaatcatg tccattgaaa tttaaatata
     6421 aatatattga tagaataaat tggaaaaatg atgatgttgg tagtagagag tattatgaaa
     6481 ctttaaaaac aggaagagat tttcatttga tttgtgaaag atattttagc aatatacctc
     6541 ttggaatcta ttttaatgag gatgataaaa atagtaaaaa gtttttaaag tggatggaaa
     6601 atataaaaaa agttgttcct attgaaaaag gaaaaacgta tttgccagaa tatgaagtaa
     6661 ggatgacatt aaatggggat ataatacagg caaagtatga tttagttgta attggaaata
     6721 acaatataga aatatgggat tggaaaaccg agtctaaaaa gattgactat aaacacgtag
     6781 aaaatagaat acaaactatt gtttatatgt ttttagcaaa agaagtaata cctaaagttt
     6841 taaaaatgga cataaatgtt aaagatataa atatgagata ttatcaacct gaatttgatg
     6901 acttaccaat taccatttta tatgatgaag aaaaacatga agcaaataga aataaaattc
     6961 aaaattatat aagtatgata aaaaacacta attatgaaga acatacatac gaagacaatc
     7021 tatacaatga tatagaaaag gtatataata aagaagaacg tatgtgctat agaaataaaa
     7081 agcattgcaa gtattgtgaa tttaataagt tatgtaatgg caaagaaata gattatagta
     7141 ttttggaggc ggaaatttat gggacttagg tttgtattag gtagaagtgg aagtggaaaa
     7201 tccacctata tactagatga aattaaaaaa gaagctcaaa aaaatgaaac gacatcaatt
     7261 atacttttag ttccagaaca gtacacattt gaggctgaaa atagagtaag taaactattt
     7321 ttaggaaaag aaaaagataa gtatctaaga gttagggtac ttagctttaa gacactaagt
     7381 aatatagttt tttctcaagt aggaggattg acagatgtaa atataaattc tagtggaaaa
     7441 gcaatgatgg tatatagagc tattgaagat gtaagtgaag aattaaatgt gttttcaaaa
     7501 tcaaaatcgc agtctggttt tgtaagttca attacagata tgatatcaga aatgaaacaa
     7561 tacaatataa gccctgaaat gttagaaaat atatctggag aattggataa tgaaacttta
     7621 agtttaaaat taaaagatat aagtaaaata tataattctt ttgaagggaa attgcatgaa
     7681 aattatgtag atgctcaaga tatgttaact tcattggcaa gtaaaattga attaagcagt
     7741 tatttagatg gagcttgtgt ttatatagat gaatttacag gttttacacc aaatcagtac
     7801 aatgtcataa agagtatatt aaataagtct aaaagtgtta atatctcttt gactgtagat
     7861 gatatcaact atattgggta cagtaaatct gatatgtttt ctagaacgaa atttacttat
     7921 tcaaaattga ctcaattgtg caacgaagaa ggcataaaaa tattgccaca agtaaattta
     7981 aacacaggtg ttataaaaag atttgaaaaa gttaaggaat tacagcactt agaaagattt
     8041 tataatgctt atccatataa aatatattca aatccaactg aaaatataaa gataaaagag
     8101 tttaacaatt tatattcaga ggtggaagag atagccagag aaattgtaca tttagttaga
     8161 gataagaatg tcagatatag agatataacc attgctacaa gagatttaaa tagatatgat
     8221 tttttagtac actctatatt taatgaatat aatataccaa actttataga taagaagaga
     8281 gaggcaaaaa gtaatccaat agttatttta attatttcag ctttagaaat gaagaataga
     8341 cgatatgggt atgaaactat gtttaggtat ttaaaaagtg gacttatagg aattgataat
     8401 gatgatataa atttactaga aaattatgtg ttggctaatg ggattaaagg taaaaaatgg
     8461 tttgatgaaa aatgggatta tagaataacc caaagtcttt caggtcaaga aagtgaattt
     8521 gaactggaat taaaagagaa aataaatgaa ataaaaaata gagtattaga gcctatagta
     8581 attttacaag aaaaattaag aggaaaaaat agagtaaaag aaatctgtag atatatatat
     8641 gaatttttat tagatataaa tatgccagaa actatagaaa gtttaatagt aaattttaag
     8701 gataaagggg aacttgatgt tgcaaatcaa tactcacaag tttgggacat agtagtggac
     8761 atattagacc aaatggtgga acttatgggt gatgaaataa tttctttaga aaaatttata
     8821 aaattaataa ccttaggttt tgatgaatat gaattaggac tggttcctcc tagtatagac
     8881 caggtacttg taagtagtgt ggatagaatg aaaaatccag acacgaaata tttataccta
     8941 gttggaacta ctgatggtgt gtttccgctg attacaaagg atagtggaat attgagtgat
     9001 aatgataggg aaagtcttgg aaacaaagga atcgaagttg atattgatag taagactagg
     9061 agttttgaag aacagtttct tgtatataaa gctcttactt cgacatctaa gaatttaacc
     9121 ataacatatc caatatcaga ccatgaaggt aaaacgctta gaccatcaat aattatatca
     9181 agacttaaga agatatttcc aaatatagaa aataaaagtt atttagtgga agaaaataaa
     9241 agcactgata aagatatact taaaaaaata acggttaaat cccctacatt taatgaactt
     9301 ataaacgtaa taaaaaatta tgacagtgat ggttacaata cagaagagat taatagtatt
     9361 tggttagata tatataggta ctatttaaaa gatgaaatct atagttctat aacaaaaaaa
     9421 gttataaaag gtcttagtta tactaatcaa gttcataaga ttgaagagaa aaaaataagg
     9481 tcattgtata aaagtaattc tcttagcata tctaggcttg aaaaatatgc tgaatgtcca
     9541 tttgcttact ttatacaata tggtctaaaa gcaaaaaagc gtaaagagta ttcatttaca
     9601 ccaccagatt taggaacttt tattcataat attttagata ggttttcaaa agaactttta
     9661 caagataatt taacttggag agatattgat gaaaaatata tagaattaaa gataggtata
     9721 atagttgatg aaataatttt aaagatacca ggatatatat taaatagttc tgagaggtat
     9781 aaataccttg catatagatt aaagaatatg ttgacaactg ctataactat aattagtcag
     9841 caaataaaac aaggttcatt tgaaccaata gattatgaag ttaaatttgg caacaatgga
     9901 aaatatccac ctataaaaat ggtgttagaa aatggacaag aagtaagttt aattggacaa
     9961 atagatagag ttgatgaatt tgaagaagga gaaaataaat atataagaat aatagattat
    10021 aagtcaggca ataagtccat aagtctaaca gaaatatatt atggtctaca attacaatta
    10081 cttgtgtatt tagatgcaat ccttgaaagt gcaaaggatg aagatataaa tataaatcca
    10141 gctgcaatac tatattgtag aataaataat ccaatagcaa aatttaatga agataaagat
    10201 gatgaagaaa tacaagaagc aatattaaaa gaacttagaa tgaaggggct tgtagtaaaa
    10261 gactctcaca tagttaaaga gatggataaa tcattaatag atggagaaag gaaaaactct
    10321 ttagtaatac cagtaggtct tactaaggat ggaaatgtag gtaaaagtac ttcagcaata
    10381 agctatgagg atttcaaact gcttagaaaa tatgtaaggc atgctataaa ggatttatgt
    10441 gaagaaatgt taagtggaga aatacgtata gctccatata aacataaaga tggaacatca
    10501 tgtgactttt gtgattactc tgctatatgt cagtttgatt caactataaa agataacaag
    10561 tataaaaatt taaataataa gagtaatgaa gagataataa aaatgatgaa aggagatgtt
    10621 aattagtgag ttctcctaaa tggacaaaag agcaattaga agttatagaa agtagagaat
    10681 gcaatttatt ggttgctgct gctgctggtt caggaaaaac agccgttcta gttgagcgta
    10741 taattcaaat gataacaagt agagaaaatc caattgatat agataagtta ttagttgtta
    10801 catttactaa tgctgctgcg tcagaaatga gagagaggat aggggatgct ataggaaaag
    10861 ccttagatga aaacccagaa aataaacatt tacaaaacca acttgtttta ttaaataaat
    10921 ctagtattac aacaatacac tcattctgtt tggatgttat aaaatcaaac tttcatagaa
    10981 taaacttaga ccctaatttc agaataggag accaaactga atgtgctatt ttgaaacaag
    11041 aagcaataga ggaagtattt gaagatttat atgaagaaag agatgagggg tttttaaatt
    11101 tagttgaaag ttatgcagaa agaggaggag ataaagaagt acaagatatt atcttgggaa
    11161 tatattcatt tgcaatggct tctcctgaac ctaaaaaatg gttgattgac tcagcagaac
    11221 gatttaatat tgatgaaaat tttgattttt cacagtctat ttgggctaga gctatattag
    11281 acactgtaaa aatagagatt aatggtcttt gtctaaatat ggaaagggca ttaaaagaag
    11341 tggaatcaat agaagaatta gaaacttttg cagaaaagtt atccgttgaa tataaaaaaa
    11401 ttgctgacat ttcacaagca tgtaataaat cttgggatga ggcatataaa aagatggcaa
    11461 gtatgtcctt tgaaaattat gtaaaaggag taaaaagaat ttcaaaagat gctccttcgt
    11521 atataaaaga atcaaaagaa aaggcaaaaa ctataagaga taagactaag aagtctttag
    11581 aaagtatagt aagtgctaca ttcaataaag ataatgattc tattagagaa gaaataaaat
    11641 atctttataa catagttaaa ccaatatcta gtgttgtact gagatttgaa gaggaatata
    11701 gcaataagaa aagagaaaaa ggaataatag attttaacga tatagagcat tttgcattaa
    11761 atatacttac agatgtagat gaaaaaggta atattgtacc ttctgatata gcagttggat
    11821 gtagaaacaa gttttatgaa atatttatag atgaatatca ggatagtaat ctagtgcagg
    11881 aagtactgct taaagctgtt gcaaatacag aaactccaaa tagatttatg gttggtgatg
    11941 taaaacagag tatatataga tttagacaag caaagccaga attatttttg caaaaatata
    12001 ataactataa tgataaaaag ggaagctccc atagaaaaat aatgctttac aaaaacttta
    12061 gaagtagaga agaagttgta gatgctgtaa attatatatt tgaaaatata atgaatgaga
    12121 atataggaga aattgaatat acagaaaaag aaagactaaa tttaggtgca aattttaatg
    12181 tggatacaga cgagaaatct attattggtg gagcaacgga gatacaccta atacaaaaag
    12241 ataataaact tgatgatgat attataaatg ataaagacga tagaattaat aacaaagaaa
    12301 atgaaataga ggaagaagaa aaattagata atatacaact tgaggctaga atggttggaa
    12361 acattatcaa agatttaatg aaagtcaatg aagatggaaa aattcaaaag gtctatgata
    12421 agggaataga tggatataga cctgtggaat ttagagatat agttattctt ttaagagcta
    12481 catctgcatg ggctccagtg tttgcagatg aattgatgaa tatggatata ccaacgtatg
    12541 ctgatgttgg agtggggtat tttgatacga ttgaaataaa aacaatattg tcattacttc
    12601 aaataataga taatccaatg caagatatac ctcttatatc tgtattaaaa tcacctatat
    12661 ttggatttac accagaggat ttgattgata ttagagttca gagtaaagat aaaatttttt
    12721 atgaggtttt aaaaagtaca gcagagtatg atggatttac agattctcaa aatgaaaatg
    12781 agtctgagtt tataccaagt gaagagtgca taaacaaaag taaagatttt ttaattaagc
    12841 taaaggaatt taaagaaaag tcaatgtaca tgagtacaga tgaatttata tggtacttgt
    12901 acacaaggac tggatactat gcctatgttg gagcattgcc aggtggaagt caaagacaag
    12961 ctaatttaaa agtattgttt gagagagcaa aacaatttga agaaaccagt cttaaaggaa
    13021 tattcaactt tgtaaatttt atagagaaat taaaaaaatc tagttctgat atgggaagtg
    13081 caaaaacact tggtgagaat gcaaatgttg ttagaataat gagtattcat aaaagtaaag
    13141 gtctagaatt tccagtagtc atatgctctg caatgggtaa aaatttcaat actcaagatt
    13201 ttaaaaagag tattttatat catcataatt tagggtatgg acctcaattt gtagactatg
    13261 agagaaggat ttcttttcca agtatagcca aagaagcatt aaaaagcaaa ataaatatag
    13321 aaaatttatc agaagagatg agagttttat atgttgcatt tacaagagct aaagaaaaat
    13381 tgattataac tggttctact agaaatatac aagatagtat aaagagatgg tcaaatggaa
    13441 ttgaaagttt agatacaata tcacaatacg agatattaaa aggtaaaaat tttttagatt
    13501 ggataatgcc ttgtgtatta agacataggg atttatctaa tctactagaa gaagtaggat
    13561 tagacgcagt ttttaatgtt gaacataatt caaaatggta tggaaagttg tggaataaga
    13621 atgatatttt agtggaaaag aagagtgatg aagaaaaaga aagtattgaa gaaattcttg
    13681 aaaaaataga tgtaaataat cctgacagtg attattacgg tgaaatagaa gaaaaattaa
    13741 actatatata tccatatgaa tttagtacaa gaaaacctgc tactatatct gttacagaaa
    13801 taaaaaagat acaaaataat tatgaagaag agttaataaa tactatattt gaacaaaaag
    13861 taatattaaa aaagcctcta tttattcaaa atgaagaaga aagagaaaaa ataagtggaa
    13921 cagaaagagg tacaatagtc catttagtta tggaggtttt agacttaaaa aatgtaagta
    13981 gtgtaaatga tataaaatca caaataagag gttttgtttc aaaaggtata ataacagaaa
    14041 aacaagctag tatagtaaat ccatataaaa tatataaatt ttttgcctct aacataggaa
    14101 aaagaatgtt gaatgctgaa attataaata gagaaaaatc aatttatgca caagtaaata
    14161 tgaaagacat atatatttat gaaaagctta taaacaatga cgataaaaaa ctttatgata
    14221 atgaaagtgt catgttaaga ggtatagttg atgcttattt tgaagaagat aatcaaatag
    14281 ttttggtgga ttataaaaca gattttgtaa atgaggaaaa tataaatcaa ataatagaga
    14341 aatataaaaa acagttggat ttatatgcag atattattga aactttaact ggtaagtcag
    14401 taaaagagaa atgtatatat ttatttggag ttgatgaagc tgtttgttat tagtttttat
    14461 atataaatta aacctaaaag atagaggaag gggaaaaaat gagatttatt catacatcag
    14521 attggcatct agggaagtcc ctagaaggcc attctagaat tgaggaacaa gcaaagtttt
    14581 gtgaggaatt tataaaaata gtagaatcaa atgaaataga tatggttata attgctggag
    14641 atgtatatga tacttctaat cccccagcac aagcagaaaa actattttat cagactgtat
    14701 caagacttgc caataatggt cagaggtgtg tattaataat ttcaggaaat catgataatc
    14761 cagagagact ctctgcaata acacctctag cacatgaaca ggggatactt atatatggtt
    14821 atccattaag tgctacgata gaagctaagt ataaagggtt tgaaataaca tatgcaactc
    14881 agggatgtac aaaactgaat ataaatggag aaaatattgt ggttgctaca ttaccttatc
    14941 caagtgaaaa aagattaaat gaagtttttt caagtgaaga tgagtttgag aaacaaaaaa
    15001 attattctga aaaggtagga gatatattta gaagtttaga agaaaatttt agaagtgata
    15061 ctataaatat agccgtatca catatatttg taataggtgg agagagtact gaatcagaaa
    15121 gacctataca gttaggtgga agttttttag ttgaaagaaa agatttgcca gaaaaggctc
    15181 aatatactgc actaggtcat ttacataaac aacaaaaagc ttccgaacgt ttaaatgcat
    15241 actattctgg ttctccactt caatatagca aggatgagag agcgtatacc aaaggggcat
    15301 acatagtgga tataaaagct ggtgaaaaac caataattga agatgtatat tttaataatt
    15361 acaaacctat agaagtattt aaatgtaatg gaatagaaga agcactagat atatgtgagc
    15421 aaaatcaaga tagagagatt tggtcatatt ttgaaataaa tactgatgag ataatatcac
    15481 agaatgaaat taaaaaaatg aaggaactat taaaagacat aatagaaata aaaccaataa
    15541 taacatcttg ttatgaacaa gaaagtgtag atataaaaga aaagtctatg gcagagttgt
    15601 ttagagagtt ctattctttt agtaaaggtg tagagccaaa aggagaactt atggatttat
    15661 ttctagatat aataagtgaa gaaggtgaat cagcagatga gaccaattag attagaactt
    15721 acagggctta atagctatat tgataaacaa gttatagact ttgaaaaatt aattgaaaga
    15781 ggtttgtttg ggatatttgg aactactgga agtggaaaat ctacaatctt agatgcaata
    15841 actattgcta tgtatggaaa tatatccaga aatacaaaag aatatataaa cagtgtgtgc
    15901 gataaggcaa ttatatcata cgagtttgag ataggaagca aaaacactag aagaagatac
    15961 attgtagata gaaccattgc tagaagcaaa acaggaacaa agacctctaa tgctagatta
    16021 atagaagtat tgaatgacaa tacccaaaat gttttagctg ataaagttgt ggaagtaaat
    16081 gaaaaagtag cacaggttgt aggattaaca gcaaatgatt ttactaggtc agtagtttta
    16141 ccacaagaca aatttaatga gtttctaaga ttatcacgtg cagatagaag agacatgtta
    16201 gagagaattt ttaatcttga gaaatatgga agaagtcttg gagaaaaagt gaaaaagaga
    16261 aaaaatatac agttacaaaa tttaaaagat ttgaaatcaa aattaagtca atatgatgga
    16321 attacagagg aagtatacaa caatataaac caagaattaa tagagttaaa aaatttggaa
    16381 aaagataagg ataatgcttt agacctagct caaaaatctt atgaagaaag taaaacagta
    16441 tatgaagaac aattaaagtt agaaaaaaat gaacttagaa aaaatgagct tgatttaaaa
    16501 aatagtgaga taaaagaaaa gattgctctt gtagaaaatg atagtaacgc taaaaaggta
    16561 gacccataca taagttcagt tcaaaatcta gaaaaaaaga tagatgaaga tagcttcgca
    16621 gtaagtaatt tagaaaagaa attagcaata ttaaatcagg agcttgaagt tacaaaaaat
    16681 agatatgaaa aaataaacaa aattaagaat gaagaagtcc ctaaattgag tgaagaaaaa
    16741 ataagattgc aacaagcaat aaaattagaa gaagagttag ttttattaga tagagagtta
    16801 aaagagctaa aagaaagtgg aattaattta aataagacta aagttgaatt agaaaaagta
    16861 aagcaggtgt cagagtccag aaaagatgca gttactaaat ctataaaaga agttgaagga
    16921 aagattgata aagtaaatat aagtgcagaa ttaaaacaaa aaatatttct agcatatgaa
    16981 tacgagaaag attacaacaa cgtattggaa gaaaaaaatc aaaagctaaa taaactagaa
    17041 gaaatactca aagagacaga aaatataaat ttaaaagtta gatatattga taaagataag
    17101 aatgatgtaa atcgtaattt agaaaattta tcacttcact tggatgttct tcttaaaaaa
    17161 tgtcctggta agagtgctga tttactttta aaatctgaat atgttactga attaagaaat
    17221 aaagcaaata atactaaaga aaatgaaatt aagaaaagca gtatacaaga tgaattaaag
    17281 ataatacttg aaagtaagtt taatactgaa agggaagtaa atttactaaa tgaaaaactt
    17341 gaaaataata gaaagaacag agatgactta gaaaaagaat tagaagaact aaagtattta
    17401 aatttagcct ctgaacttag acgtgaatta aaagaaaata tgccttgtcc agtttgtggg
    17461 tcaaaacatc atgaaaatca tgatataact aagtatgatg aaaatatatc ttttgtcaaa
    17521 gaaaaactgg agaaattaga aaaagaaaaa ataagtataa gaaacaatat agaggaatta
    17581 aatgctaaag taagtgggta tttatctata gaaaaaatga agactaaaga acttgaagat
    17641 gtaaaaggaa aactaggggg gattccatct agtcaattat taaaaaaact tgatgaagaa
    17701 caaagaaaac ttgcattgtt aaaatctaat attcaggagt gggagaaaga aaaagagagt
    17761 actgaaaata aagtaacatt agctaaagaa gaaaaaaata aaattgaaaa agaagaatta
    17821 aaaataagag agagtctgaa taattataag aaattaacaa gagatttaaa catagaaata
    17881 gaaggtttag aaaataaatg taaaaaactt aaacaggaat acctaggatt aaagacgatt
    17941 actaaagtct ctaatctatt gtcaaaagta aaagaaataa gagagaatga aaaagaatta
    18001 gaattactaa gtactgggca ttcaaattta ttaaaaaata gagactcact agatattaaa
    18061 ataagagaaa atgagagtaa actacatgaa atagagatag aattaataaa ggctagagaa
    18121 ttatatgtag aaaagaaatt gagtagagat aataagtata aagaagttat tagcataacg
    18181 aaaggtgatt tagctaaaaa tcttttacat aatgttgaag aaaatatatg taagatatta
    18241 gaacaagaag aatcaagtaa gaaaaaattg gaagagcaaa gattagaata tgaaaaaaac
    18301 attgctgaaa agcacaatat agatggtaga cttaaaactg ctaaggaaca atataaagac
    18361 caaaaatcaa cactaaataa actattagca gaaaataaat ttgaaagtat atatgcagta
    18421 aaaagagctt tattagatac tgatgcagta aaaaaattga ttgaagaaat actagagcat
    18481 gaagaagaac aaaagttatt atcatttaaa ataaaatcat caaaagaaaa attaaatgga
    18541 agaagcataa agaaggagta ctttgaacag ttaaaagatg aaatttataa tttgaaagta
    18601 gaaataggaa atatatccaa agatattgga gctaatcaaa atcagttaat aacattaaaa
    18661 gactctttag ataagataaa tgattttaat aaacaactta aggtagttga acacaatgtg
    18721 gacttattgg aagaattaga taaatgtgta caaggaaata aatttgtaga atatgtttct
    18781 acaaaccaat taaaatatat agcgttggaa gcatcaaaac gattggatgg aataacaaaa
    18841 ggaagatatg cacttgaaat tgactcaaca ctaaactttg taatgagaga taactttaat
    18901 ggaggagaaa gaagaagcat tgatactcta tctggtggag agacattctt gacatctcta
    18961 tcattagcac ttgctctttc atctcaaata caattaaagg gaagtgcacc attagaattt
    19021 ttctttttag atgaaggttt tggttcatta gatagtgaac ttttagaaat tgttatagaa
    19081 tcattggaaa gattgcatag taataatcta agtgtgggta taataagtca tgtcgaggaa
    19141 cttaaaaata gagttcctgt taagctatta gtttcatcta gtgaggctgg aataggttca
    19201 aaagtaaaaa ttgaatatag ttagaaaata tatgttaatt gaatatatta tctaatattt
    19261 ccaaataata tgtaattgtg atataataaa aactaatatt aaagttattt ataattaata
    19321 ttaatataaa aacatgtaag taggagtgtg gtaagtgttg gaatcgccca ataatttgat
    19381 tcagattatt tttttaatag tattacttat agggtctgca tttttctcag catctgaaac
    19441 ggctttaatg tcgttgagta aaatcagaat cagatatatg caagatgaag gagttaaagg
    19501 agctaagtta gtaagttcat taatagaaaa tccaaataag cttttaagtt ctatattggt
    19561 tggaaataac gtcgtaaata tagcagcaac atccatatca acatctttgt ttataggatt
    19621 aatgggagaa aaaggagtgg cacttgctac agctgttatg acagtattag tattaatatt
    19681 tggtgagatt actccaaaaa caatagcagc aaataattca gaaaaggttt ctctattagt
    19741 atctaaacct ataaaagcaa ttatatttat attaagacca atagtatgga tatttaatat
    19801 aattacaaat attatattta aattatttgg tataacaaat aaaggagcta aatcattcat
    19861 aactgaagaa gagctaaaaa ctatggtaaa tgtaagtcat gaagaaggcg tccttgaaat
    19921 ggaagagaga gaaatcataa ataatgtttt tgaatttgga gatatgcaag ctaaaaatgc
    19981 aatggtacaa agaatagata tggtagctat agatatggaa gatagttatg atgagataat
    20041 acaggtattt aaaactgaaa aattaagcag aatgcctgtg tatgaagaaa ctatagatga
    20101 tattgtagga atacttaata taaaagatat tatattttta tctgatgaag aaatagagtc
    20161 atttgatatt aaaaattata tgagagaacc ttttttcacg tatgagttca aaaagataac
    20221 acaacttctt gaagagatga aacttgaaaa aagtcagatg gctatagttg tagatgagta
    20281 tggtggaaca tctggacttt taactataga agatttagta gaagtcattg ttggagatat
    20341 agaggatgaa tatgatgaag aagaggatga aatacaagtt ataaaagaag atgagtatat
    20401 tgtagatgga agtactaaaa ttggtgatgt taatgaactt attggtgtaa acttggaatc
    20461 tgaggagttt gattccatag gaggttttat aattggacac ctaagcagat tgccagaaga
    20521 aaatgaagta attgaggttg ataatataag attttgtata gaaagtatag aaaaaaatag
    20581 aattaaaaaa ataagaatat atacaacaac agaaggttta tcagtagaac aatttaaaga
    20641 gctactaaaa tattatccaa tacaacattt atctaaacta gaaaaagcac ttggatagca
    20701 gtatt
//
LOCUS       DAEHWM010000077        20311 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.078, whole genome shotgun sequence.
ACCESSION   DAEHWM010000077 DAEHWM010000000
VERSION     DAEHWM010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 20311)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20311)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20311
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.078"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            41..595
                     /gene="tcdR"
                     /locus_tag="KNP36_002752"
     CDS             41..595
                     /gene="tcdR"
                     /locus_tag="KNP36_002752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin sigma factor TcdR"
                     /protein_id="HBF0874612.1"
                     /translation="MQKSFYELIVLARNNSVDDLQEILFMFKPLVKKLSRVLHYEEGE
                     TDLIIFFIELIKNIKLSSFSEKSDAIIVKYIHKSLLNKTFELSRRYSKMKFNFVEFDE
                     NILNMKNNYQSKSIFEEDICFFGYILKELSGIQRKVIFYKYLKGYSDREISVKLKISR
                     QAVNKAKNRAFKKIKKDYENYFNL"
     gene            913..8013
                     /gene="tcdB"
                     /locus_tag="KNP36_002753"
                     /gene_synonym="toxB"
     CDS             913..8013
                     /gene="tcdB"
                     /locus_tag="KNP36_002753"
                     /gene_synonym="toxB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_074049122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin TcdB"
                     /protein_id="HBF0874613.1"
                     /translation="MSLVNRKQLEKMANVRFRTQEDEYVAILDALEEYHNMSENTVVE
                     KYLKLKDINSLTDIYIDTYKKSGRNKALKKFKEYLVTEVLELKNNNLTPVEKNLHFVW
                     IGGQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTVVESAINDTLESFREN
                     LNDPRFDYNKFFRKRMEIIYDKQKNFINYYKAQREENPELIIDDIVKTYLSNEYSKEI
                     DELNTYIEESLNKITQNSGNDVRNFEEFKNGESFNLYEQELVERWNLAAASDILRISA
                     LKEIGGMYLDVDMLPGIQPDLFESIEKPSSVTVDFWEMTKLEAIMKYKEYIPEYTSEH
                     FDMLDEEVQSSFESVLASKSDKSEIFSSLGDMEASPLEVKIAFNSKGIINQGLISVKD
                     SYCSNLIVKQIENRYKILNNSLNPAISEDNDFNTTTNTFIDSIMAEANADNGRFMMEL
                     GKYLRVGFFPDVKTTINLSGPEAYAAAYQDLLMFKEGSMNIHLIEADLRNFEISKTNI
                     SQSTEQEMASLWSFDDARAKAQFEEYKRNYFEGSLGEDDNLDFSQNIVVDKEYLLEKI
                     SSLARSSERGYIHYIVQLQGDKISYEAACNLFAKTPYDSVLFQKNIEDSEIAYYYNPG
                     DGEIQEIDKYKIPSIISDRPKIKLTFIGHGKDEFNTDIFAGFDVDSLSTEIEAAIDLA
                     KEDISPKSIEINLLGCNMFSYSINVEETYPGKLLLKVKDKISELMPSISQDSIIVSAN
                     QYEVRINSEGRRELLDHSGEWINKEESIIKDISSKEYISFNPKENKITVKSKNLPELS
                     TLLQEIRNNSNSSDIELEEKVMLTECEINVISNIDTQIVEERIEEAKNLTSDSINYIK
                     DEFKLIESISDALCDLKQQNELEDSHFISFEDISETDEGFSIRFINKETGESIFVETE
                     KTIFSEYANHITEEISKIKGTIFDTVNGKLVKKVNLDTTHEVNTLNAAFFIQSLIEYN
                     SSKESLSNLSVAMKVQVYAQLFSTGLNTITDAAKVVELVSTALDETIDLLPTLSEGLP
                     IIATIIDGVSLGAAIKELSETSDPLLRQEIEAKIGIMAVNLTTATTAIITSSLGVASG
                     FSILLVPLAGISAGIPSLVNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDDKIMMP
                     QDDLVISEIDFNNNSIVLGKCEIWRMEGGSGHTVTDDIDHFFSAPSITYREPHLSIYD
                     VLEVQKEELDLSKDLMVLPNAPNRVFAWETGWTPGLRSLENDGTKLLDRIRDNYEGEF
                     YWRYFAFIADALITTLKPRYEDTNIRINLDSNTRSFIVPIITTEYIREKLSYSFYGSG
                     GTYALSLSQYNMGINIELSESDVWIIDVDNVVRDVTIESDKIKKGDLIEGILSTLSIE
                     ENKIILNSHEINFSGEVNGSNGFVSLTFSILEGINAIIEVDLLSKSYKLLISGELKIL
                     MLNSNHIQQKIDYIGFNSELQKNIPYSFVDSEGKENGFINGSTKEGLFVSELPDVVLI
                     SKVYMDDSKPSFGYYSNNLKDVKVITKDNVNILTGYYLKDDIKISLSLTLQDEKTIKL
                     NSVHLDESGVAEILKFMNRKGNTNTSDSLMSFLESMNIKSIFVNFLQSNIKFILDANF
                     IISGTTSIGQFEFICDENDNIQPYFIKFNTLETNYTLYVGNRQNMIVEPNYDLDDSGD
                     ISSTVINFSQKYLYGIDSCVNKVVISPNIYTDEINITPVYETNNTYPEVIVLDANYIN
                     EKINVNINDLSIRYVWSNDGNDFILMSTSEENKVSQVKIRFVNVFKDKTLANKLSFNF
                     SDKQDVPVSEIILSFTPSYYEDGLIGYDLGLVSLYNEKFYINNFGMMVSGLIYINDSL
                     YYFKPPVNNLITGFVTVGDDKYYFNPINGGAASIGETIIDDKNYYFNQSGVLQTGVFS
                     TEDGFKYFAPANTLDENLEGEAIDFTGKLIIDENIYYFDDNYRGAVEWKELDGEMHYF
                     SPETGKAFKGLNQIGDYKYYFNSDGVMQKGFVSINDNKHYFDDSGVMKVGYTEIDGKH
                     FYFAENGEMQIGVFNTEDGFKYFAHHNEDLGNEEGEEISYSGILNFNNKIYYFDDSFT
                     AVVGWKDLEDGSKYYFDEDTAEAYIGLSLINDGQYYFNDDGIMQVGFVTINDKVFYFS
                     DSGIIESGVQNIDDNYFYIDDNGIVQIGVFDTSDGYKYFAPANTVNDNIYGQAVEYSG
                     LVRVGEDVYYFGETYTIETGWIYDMENESDKYYFNPETKKACKGINLIDDIKYYFDEK
                     GIMRTGLISFENNNYYFNENGEMQFGYINIEDKMFYFGEDGVMQIGVFNTPDGFKYFA
                     HQNTLDENFEGESINYTGWLDLDEKRYYFTDEYIAATGSVIIDGEEYYFDPDTAQLVI
                     SE"
     gene            8135..8635
                     /gene="tcdE"
                     /locus_tag="KNP36_002754"
     CDS             8135..8635
                     /gene="tcdE"
                     /locus_tag="KNP36_002754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holin-like glycosylating toxin export protein
                     TcdE"
                     /protein_id="HBF0874614.1"
                     /translation="MHSSSPFYISNGNKIFFYINLGGVMNMTISFLSEHIFIKLVILT
                     ISFDTLLGCLSAIKSRKFNSSFGIDGGIRKVAMIACIFFLSVVDILTKFNFLFMLPQD
                     CINFLRLKHLGISEFFSILFILYESVSILKNMCLCGLPVPKRLKEKIAILLDAMTDEM
                     NAKDEK"
     gene            8940..9146
                     /locus_tag="KNP36_002755"
     CDS             8940..9146
                     /locus_tag="KNP36_002755"
                     /inference="COORDINATES: protein motif:HMM:NF022413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874615.1"
                     /translation="MKLFKNTKIRDEGQNDIENKYQTLINDLIDSLKVIGKIYKEIKT
                     LKKYKICLQITIRQSPYLIEESIN"
     gene            9363..17495
                     /gene="tcdA"
                     /locus_tag="KNP36_002756"
                     /gene_synonym="toxA"
     CDS             9363..17495
                     /gene="tcdA"
                     /locus_tag="KNP36_002756"
                     /gene_synonym="toxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_105161403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin TcdA"
                     /protein_id="HBF0874616.1"
                     /translation="MSLISKEELIKLAYSIRPRENEYKTILTNLDEYNKLTTNNNENK
                     YLQLKKLNESIDVFMNKYKTSSRNRALSNLKKDILKEVILIKNSNTSPVEKNLHFVWI
                     GGEVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNTLKKAIVESSTTEALQLLEEEI
                     QNPQFDNMKFYKKRMEFIYDRQKRFINYYKSQINKPTVPTIDDIIKSHLVSEYNRDET
                     VLESYRTNSLRKINSNHGIDIRANSLFTEQELLNIYSQELLNRGNLAAASDIVRLLAL
                     KNFGGVYLDVDMLPGIHSDLFKTISRPSSIGLDRWEMIKLEAIMKYKKYINNYTSENF
                     DKLDQQLKDNFKLIIESKSEKSEIFSKLENLNVSDLEIKIAFALGSVINQALISKQGS
                     YLTNLVIEQVKNRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIA
                     PYLQVGFMPEARSTISLSGPGAYASAYYDFINLQENTIEKTLKASDLIEFKFPENNLS
                     QLTEQEINSLWSFDQASAKYQFEKYVRDYTGGSLSEDNGVDFNKNTALDKNYLLNNKI
                     PSNNVEEAGSKNYVHYIIQLQGDDISYEATCNLFSKNPKNSIIIQRNMNESAKSYFLS
                     DDGESILELNKYRIPERLKNKEKVKVTFIGHGKDEFNTSEFARLSVDSLSNEISSFLD
                     TIKLDISPKNVEVNLLGCNMFSYDFNVEETYPGKLLLSIMDKITSTLPDVNKNSITIG
                     ANQYEVRINSEGRKELLAHSGKWINKEEAIMSDLSSKEYIFFDSIDNKLKAKSKNIPG
                     LASISEDIKTLLLDASVSPDTKFILNNLKLNIESSIGDYIYYEKLEPVKNIIHNSIDD
                     LIDEFNLLENVSDELYELKKLNNLDEKYLISFEDISKNNSTYSVRFINKSNGESVYVE
                     TEKEIFSKYSEHITKEISTIKNSIITDVNGNLLDNIQLDHTSQVNTLNAAFFIQSLID
                     YSSNKDVLNDLSTSVKVQLYAQLFSTGLNTIYDSIQLVNLISNAVNDTINVLPTITEG
                     IPIVSTILDGINLGAAIKELLDEHDPLLKKELEAKVGVLAINMSLSIAATVASIVGIG
                     AEVTIFLLPIAGISAGIPSLVNNELILHDKATSVVNYFNHLSESKKYGPLKTEDDKIL
                     VPIDDLVISEIDFNNNSIKLGTCNILAMEGGSGHTVTGNIDHFFSSPSISSHIPSLSI
                     YSAIGIETENLDFSKKIMMLPNAPSRVFWWETGAVPGLRSLENDGTRLLDSIRDLYPG
                     KFYWRFYAFFDYAITTLKPVYEDTNIKIKLDKDTRNFIMPTITTNEIRNKLSYSFDGA
                     GGTYSLLLSSYPISTNINLSKDDLWIFNIDNEVREISIENGTIKKGKLIKDVLSKIDI
                     NKNKLIIGNQTIDFSGDIDNKDRYIFLTCELDDKISLIIEINLVAKSYSLLLSGDKNY
                     LISNLSNTIEKINTLGLDSKNIAYNYTDESNNKYFGAISKTSQKSIIHYKKDSKNILE
                     FYNDSTLEFNSKDFIAEDINVFMKDDINTITGKYYVDNNTDKSIDFSISLVSKNQVKV
                     NGLYLNESVYSSYLDFVKNSDGHHNTSNFMNLFLDNISFWKLFGFENINFVIDKYFTL
                     VGKTNLGYVEFICDNNKNIDIYFGEWKTSSSKSTIFSGNGRNVVVEPIYNPDTGEDIS
                     TSLDFSYEPLYGIDRYINKVLIAPDLYTSLININTNYYSNEYYPEIIVLNPNTFHKKV
                     NINLDSSSFEYKWSTEGSDFILVRYLEESNKKILQKIRIKGILSNTQSFNKMSIDFKD
                     IKKLSLGYIMSNFKSFNSENELDRDHLGFKIIDNKTYYYDEDSKLVKGLININNSLFY
                     FDPIEFNLVTGWQTINGKKYYFDINTGAALTSYKIINGKHFYFNNDGVMQLGVFKGPD
                     GFEYFAPANTQNNNIEGQAIVYQSKFLTLNGKKYYFDNDSKAVTGWRIINNEKYYFNP
                     NNAIAAVGLQVIDNNKYYFNPDTAIISKGWQTVNGSRYYFDTDTAIAFNGYKTIDGKH
                     FYFDSDCVVKIGVFSTSNGFEYFAPANTYNNNIEGQAIVYQSKFLTLNGKKYYFDNNS
                     KAVTGWQTIDSKKYYFNTNTAEAATGWQTIDGKKYYFNTNTAEAATGWQTIDGKKYYF
                     NTNTAIASTGYTIINGKHFYFNTDGIMQIGVFKGPNGFEYFAPANTDANNIEGQAILY
                     QNEFLTLNGKKYYFGSDSKAVTGWRIINNKKYYFNPNNAIAAIHLCTINNDKYYFSYD
                     GILQNGYITIERNNFYFDANNESKMVTGVFKGPNGFEYFAPANTHNNNIEGQAIVYQN
                     KFLTLNGKKYYFDNDSKAVTGWQTIDGKKYYFNLNTAEAATGWQTIDGKKYYFNLNTA
                     EAATGWQTIDGKKYYFNTNTFIASTGYTSINGKHFYFNTDGIMQIGVFKGPNGFEYFA
                     PANTHNNNIEGQAILYQNKFLTLNGKKYYFGSDSKAVTGLRTIDGKKYYFNTNTAVAV
                     TGWQTINGKKYYFNTNTSIASTGYTIISGKHFYFNTDGIMQIGVFKGPDGFEYFAPAN
                     TDANNIEGQAIRYQNRFLYLHDNIYYFGNNSKAATGWVTIDGNRYYFEPNTAMGANGY
                     KTIDNKNFYFRNGLPQIGVFKGSNGFEYFAPANTDANNIEGQAIRYQNRFLHLLGKIY
                     YFGNNSKAVTGWQTINGKVYYFMPDTAMAAAGGLFEIDGVIYFFGVDGVKAPGIYG"
     gene            complement(17830..18528)
                     /gene="tcdC"
                     /locus_tag="KNP36_002757"
     CDS             complement(17830..18528)
                     /gene="tcdC"
                     /locus_tag="KNP36_002757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosylating toxin anti-sigma factor TcdC"
                     /protein_id="HBF0874617.1"
                     /translation="MFSKKNEGNEFSNEGKGSSKKIIKFFKSTKGIALLAFILGVFFG
                     NISSPACSEDHEEVISNQTSVIDSQKTEIETLNSKLSDAEPWFKMKDDEKKAIEAENQ
                     RKAEEAKKAEEAKKAEEQRKKEEEEKKGYDTGITYDQLARTPDDYKYKKVKFEGKVIQ
                     VIEDGDEVQIRLAVSGNYDKVVLCSYKKSITPSRVLEDDYITIRGISAGTITYESTMG
                     GNITIPGIAVEKIN"
     gene            18954..19199
                     /locus_tag="KNP36_002758"
     CDS             18954..19199
                     /locus_tag="KNP36_002758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Pathogenicity locus"
                     /protein_id="HBF0874618.1"
                     /translation="MGELQKIPGVGKATEKSLIMLGYTTIKSLKDANPAQMYEKECLM
                     RGQHIDRCQLYVYRCAVYFASTENPEPEKLKWWYWKD"
     gene            complement(19417..19686)
                     /locus_tag="KNP36_002759"
     CDS             complement(19417..19686)
                     /locus_tag="KNP36_002759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBF0874619.1"
                     /translation="MFESRCGVCCDSCTKKEQVNCTGCPTMEKPFWGGECKVKTCCES
                     KELNHCGECDTFPCDMLLNKGKDQGFDPMVNIEQCRKWLEETVSN"
BASE COUNT         8049 a         2285 c         3078 g         6899 t
ORIGIN      
        1 caaataaatc atcattataa atataagaga ggatgatttt atgcaaaagt ctttttatga
       61 attaattgtt ttagcaagaa ataactcagt agatgatttg caagaaattt tatttatgtt
      121 taagccatta gtaaaaaaac ttagtagagt tttacattat gaagagggag aaacagattt
      181 aataatattt tttattgaat taataaaaaa tattaaatta agtagctttt cagaaaaaag
      241 cgatgctatt atagtcaaat atattcataa atcattactg aataagactt ttgagttgtc
      301 tagaagatat tctaaaatga agtttaattt tgtagaattt gatgaaaata tcttaaatat
      361 gaaaaataat tatcaaagta agtctatttt tgaggaagat atttgttttt tcggatatat
      421 tttgaaagaa ttatctggta ttcaaagaaa agttattttt tataaatatt taaaaggata
      481 ttctgataga gaaatatcag tgaaattaaa aatatctaga caagctgtta ataaggctaa
      541 aaatagagca tttaaaaaaa taaaaaaaga ctatgaaaat tattttaact tgtaattaat
      601 gagtttaaag aaatatttac aatagaaatc aaattttata attaacttta ttgtaaaatt
      661 aataacttaa tctaagaata tcttaatttt tatattttat atagaacaat gtttacatat
      721 ttatttcaga caacgtcttt attcaatcga agagcaaatt aatcaactga gtgtcttaaa
      781 tttaaaatgt taggaagtga atgtatatga aaacctaagt agatattagt atattttata
      841 aatagaaagg aggatatata aaagagtttt agcatttaga tgtaaaaata ttatagtaaa
      901 ggagaaaatt ttatgagttt agttaataga aaacagttag aaaaaatggc aaatgtaaga
      961 tttcgtactc aagaagatga atatgttgca atattggatg ctttagaaga atatcataat
     1021 atgtcagaga atactgtagt cgaaaaatat ttaaaattaa aagatataaa tagtttaaca
     1081 gatatttata tagatacata taaaaaatct ggtagaaata aagccttaaa aaaatttaag
     1141 gaatatctag ttacagaagt attagagcta aagaataata atttaactcc agttgagaaa
     1201 aatttacatt ttgtttggat tggaggtcaa ataaatgaca ctgctattaa ttatataaat
     1261 caatggaaag atgtaaatag tgattataat gttaatgttt tttatgatag taatgcattt
     1321 ttgataaaca cattgaaaaa aactgtagta gaatcagcaa taaatgatac acttgaatca
     1381 tttagagaaa acttaaatga ccctagattt gactataata aattcttcag aaaacgtatg
     1441 gaaataattt atgataaaca gaaaaatttc ataaactact ataaagctca aagagaagaa
     1501 aatcctgaac ttataattga tgatattgta aagacatatc tttcaaatga gtattcaaag
     1561 gagatagatg aacttaatac ctatattgaa gaatccttaa ataaaattac acagaatagt
     1621 ggaaatgatg ttagaaactt tgaagaattt aaaaatggag agtcattcaa cttatatgaa
     1681 caagagttgg tagaaaggtg gaatttagct gctgcttctg acatattaag aatatctgca
     1741 ttaaaagaaa ttggtggtat gtatttagat gttgatatgt taccaggaat acaaccagac
     1801 ttatttgagt ctatagagaa acctagttca gtaacagtgg atttttggga aatgacaaag
     1861 ttagaagcta taatgaaata caaagaatat ataccagaat atacctcaga acattttgac
     1921 atgttagacg aagaagttca aagtagtttt gaatctgttc tagcttctaa gtcagataaa
     1981 tcagaaatat tctcatcact tggtgatatg gaggcatcac cactagaagt taaaattgca
     2041 tttaatagta agggtattat aaatcaaggg ctaatttctg tgaaagactc atattgtagc
     2101 aatttaatag taaaacaaat cgagaataga tataaaatat tgaataatag tttaaatcca
     2161 gctattagcg aggataatga ttttaatact acaacgaata cctttattga tagtataatg
     2221 gctgaagcta atgcagataa tggtagattt atgatggaac taggaaagta tttaagagtt
     2281 ggtttcttcc cagatgttaa aactactatt aacttaagtg gccctgaagc atatgcggca
     2341 gcttatcaag atttattaat gtttaaagaa ggcagtatga atatccattt gatagaagct
     2401 gatttaagaa actttgaaat ctctaaaact aatatttctc aatcaactga acaagaaatg
     2461 gctagcttat ggtcatttga cgatgcaaga gctaaagctc aatttgaaga atataaaagg
     2521 aattattttg aaggttctct tggtgaagat gataatcttg atttttctca aaatatagta
     2581 gttgacaagg agtatctttt agaaaaaata tcttcattag caagaagttc agagagagga
     2641 tatatacact atattgttca gttacaagga gataaaatta gttatgaagc agcatgtaac
     2701 ttatttgcaa agactcctta tgatagtgta ctatttcaga aaaatataga agattcagaa
     2761 attgcatatt attataatcc tggagatggt gaaatacaag aaatagacaa gtataaaatt
     2821 ccaagtataa tttctgatag acctaagatt aaattaacat ttattggtca tggtaaagat
     2881 gaatttaata ctgatatatt tgcaggtttt gatgtagatt cattatccac agaaatagaa
     2941 gcagcaatag atttagctaa agaggatatt tctcctaagt caatagaaat aaatttatta
     3001 ggatgtaata tgtttagcta ctctatcaac gtagaggaga cttatcctgg aaaattatta
     3061 cttaaagtta aagataaaat atcagaatta atgccatcta taagtcaaga ctctattata
     3121 gtaagtgcaa atcaatatga agttagaata aatagtgaag gaagaagaga attattggat
     3181 cattctggtg aatggataaa taaagaagaa agtattataa aggatatttc atcaaaagaa
     3241 tatatatcat ttaatcctaa agaaaataaa attacagtaa aatctaaaaa tttacctgag
     3301 ctatctacat tattacaaga aattagaaat aattctaatt caagtgatat tgaactagaa
     3361 gaaaaagtaa tgttaacaga atgtgagata aatgttattt caaatataga tacgcaaatt
     3421 gttgaggaaa ggattgaaga agctaagaat ttaacttctg actctattaa ttatataaaa
     3481 gatgaattta aactaataga atctatttct gatgcactat gtgacttaaa acaacagaat
     3541 gaattagaag attctcattt tatatctttt gaggacatat cagagactga tgagggattt
     3601 agtataagat ttattaataa agaaactgga gaatctatat ttgtagaaac tgaaaaaaca
     3661 atattctctg aatatgctaa tcatataact gaagagattt ctaagataaa aggtactata
     3721 tttgatactg taaatggtaa gttagtaaaa aaagtaaatt tagatactac acacgaagta
     3781 aatactttaa atgctgcatt ttttatacaa tcattaatag aatataatag ttctaaagaa
     3841 tctcttagta atttaagtgt agcaatgaaa gtccaagttt acgctcaatt atttagtact
     3901 ggtttaaata ctattacaga tgcagccaaa gttgttgaat tagtatcaac tgcattagat
     3961 gaaactatag acttacttcc tacattatct gaaggattac ctataattgc aactattata
     4021 gatggtgtaa gtttaggtgc agcaatcaaa gagctaagtg aaacgagtga cccattatta
     4081 agacaagaaa tagaagctaa gataggtata atggcagtaa atttaacaac agctacaact
     4141 gcaatcatta cttcatcttt gggggtagct agtggattta gtatactttt agttccttta
     4201 gcaggaattt cagcaggtat accaagctta gtaaacaatg aacttgtact tcgagataag
     4261 gcaacaaagg ttgtagatta ttttaaacat gtttcattag ttgaaactga aggagtattt
     4321 actttattag atgataaaat aatgatgcca caagatgatt tagtgatatc agaaatagat
     4381 tttaataata attcaatagt tttaggtaaa tgtgaaatct ggagaatgga aggtggttca
     4441 ggtcatactg taactgatga tatagatcac ttcttttcag caccatcaat aacatataga
     4501 gagccacact tatctatata tgacgtattg gaagtacaaa aagaagaact tgatttgtca
     4561 aaagatttaa tggtattacc taatgctcca aatagagtat ttgcttggga aacaggatgg
     4621 acaccaggtt taagaagctt agaaaatgat ggcacaaaac tgttagaccg tataagagat
     4681 aactatgaag gtgagtttta ttggagatat tttgctttta tagctgatgc tttaataaca
     4741 acattaaaac caagatatga agatactaat ataagaataa atttagatag taatactaga
     4801 agttttatag ttccaataat aactacagaa tatataagag aaaaattatc atattctttc
     4861 tatggttcag gaggaactta tgcattgtct ctttctcaat ataatatggg tataaatata
     4921 gaattaagtg aaagtgatgt ttggattata gatgttgata atgttgtgag agatgtaact
     4981 atagaatctg ataaaattaa aaaaggtgat ttaatagaag gtattttatc tacactaagt
     5041 attgaagaga ataaaattat cttaaatagc catgagatta atttttctgg tgaggtaaat
     5101 ggaagtaatg gatttgtttc tttaacattt tcaattttag aaggaataaa tgcaattata
     5161 gaagttgatt tattatctaa atcatataaa ttacttattt ctggcgaatt aaaaatattg
     5221 atgttaaatt caaatcatat tcaacagaaa atagattata taggattcaa tagcgaatta
     5281 cagaaaaata taccatatag ctttgtagat agtgaaggaa aagagaatgg ttttattaat
     5341 ggttcaacaa aagaaggttt atttgtatct gaattacctg atgtagttct tataagtaag
     5401 gtttatatgg atgatagtaa gccttcattt ggatattata gtaataattt gaaagatgtc
     5461 aaagttataa ctaaagataa tgttaatata ttaacaggtt attatcttaa ggatgatata
     5521 aaaatctctc tttctttgac tctacaagat gaaaaaacta taaagttaaa tagtgtgcat
     5581 ttagatgaaa gtggagtagc tgagattttg aagttcatga atagaaaagg taatacaaat
     5641 acttcagatt ctttaatgag ctttttagaa agtatgaata taaaaagtat tttcgttaat
     5701 ttcttacaat ctaatattaa gtttatatta gatgctaatt ttataataag tggtactact
     5761 tctattggcc aatttgagtt tatttgtgat gaaaatgata atatacaacc atatttcatt
     5821 aagtttaata cactagaaac taattatact ttatatgtag gaaatagaca aaatatgata
     5881 gtggaaccaa attatgattt agatgattct ggagatatat cttcaactgt tatcaatttc
     5941 tctcaaaagt atctttatgg aatagacagt tgtgttaata aagttgtaat ttcaccaaat
     6001 atttatacag atgaaataaa tataacgcct gtatatgaaa caaataatac ttatccagaa
     6061 gttattgtat tagatgcaaa ttatataaat gaaaaaataa atgttaatat caatgatcta
     6121 tctatacgat atgtatggag taatgatggt aatgatttta ttcttatgtc aactagtgaa
     6181 gaaaataagg tgtcacaagt taaaataaga ttcgttaatg tttttaaaga taagactttg
     6241 gcaaataagc tatcttttaa ctttagtgat aaacaagatg tacctgtaag tgaaataatc
     6301 ttatcattta caccttcata ttatgaggat ggattgattg gctatgattt gggtctagtt
     6361 tctttatata atgagaaatt ttatattaat aactttggaa tgatggtatc tggattaata
     6421 tatattaatg attcattata ttattttaaa ccaccagtaa ataatttgat aactggattt
     6481 gtgactgtag gcgatgataa atactacttt aatccaatta atggtggagc tgcttcaatt
     6541 ggagagacaa taattgatga caaaaattat tatttcaacc aaagtggagt gttacaaaca
     6601 ggtgtattta gtacagaaga tggatttaaa tattttgccc cagctaatac acttgatgaa
     6661 aacctagaag gagaagcaat tgattttact ggaaaattaa ttattgacga aaatatttat
     6721 tattttgatg ataattatag aggagctgta gaatggaaag aattagatgg tgaaatgcac
     6781 tattttagcc cagaaacagg taaagctttt aaaggtctaa atcaaatagg tgattataaa
     6841 tactatttca attctgatgg agttatgcaa aaaggatttg ttagtataaa tgataataaa
     6901 cactattttg atgattctgg tgttatgaaa gtaggttaca ctgaaataga tggcaagcat
     6961 ttctactttg ctgaaaacgg agaaatgcaa ataggagtat ttaatacaga agatggattt
     7021 aaatattttg ctcatcataa tgaagattta ggaaatgaag aaggtgaaga aatctcatat
     7081 tctggtatat taaatttcaa taataaaatt tactattttg atgattcatt tacagctgta
     7141 gttggatgga aagatttaga ggatggttca aagtattatt ttgatgaaga tacagcagaa
     7201 gcatatatag gtttgtcatt aataaatgat ggtcaatatt attttaatga tgatggaatt
     7261 atgcaagttg gatttgtcac tataaatgat aaagtcttct acttctctga ctctggaatt
     7321 atagaatctg gagtacaaaa catagatgac aattatttct atatagatga taatggtata
     7381 gttcaaattg gtgtatttga tacttcagat ggatataaat attttgcacc tgctaatact
     7441 gtaaatgata atatttacgg acaagcagtt gaatatagtg gtttagttag agttggggaa
     7501 gatgtatatt attttggaga aacatataca attgagactg gatggatata tgatatggaa
     7561 aatgaaagtg ataaatatta tttcaatcca gaaactaaaa aagcatgcaa aggtattaat
     7621 ttaattgatg atataaaata ttattttgat gagaagggca taatgagaac gggtcttata
     7681 tcatttgaaa ataataatta ttactttaat gagaatggtg aaatgcaatt tggttatata
     7741 aatatagaag ataagatgtt ctattttggt gaagatggtg tcatgcagat tggagtattt
     7801 aatacaccag atggatttaa atactttgca catcaaaata ctttggatga gaattttgag
     7861 ggagaatcaa taaactatac tggttggtta gatttagatg aaaagagata ttattttaca
     7921 gatgaatata ttgcagcaac tggttcagtt attattgatg gtgaggagta ttattttgat
     7981 cctgatacag ctcaattagt gattagtgaa tagataaaaa tatgttaaat atatcctctt
     8041 atacttaaat atataaaaat aaacaaaatg atacactaca taaagtgttc tatctaatat
     8101 gaagatttac caataaaaag gtggactatg atgaatgcac agtagttcac ctttttatat
     8161 ttctaatggt aacaaaatat ttttttatat aaacctagga ggcgttatga atatgacaat
     8221 atctttttta tcagagcata tatttataaa gttagtaatt ttaactatat catttgatac
     8281 attattagga tgtttaagtg caataaaaag tcgtaaattt aattctagtt ttggaataga
     8341 tggaggaatc agaaaagtag caatgatagc atgtatattt tttttatcag tagttgacat
     8401 tcttacaaag tttaactttt tatttatgtt accacaagat tgtatcaatt ttttaagact
     8461 aaaacatctt ggaatatctg aatttttctc tattttattt attttatatg aaagtgtaag
     8521 tatattaaaa aatatgtgct tatgtggatt accagtacct aagagattaa aggaaaaaat
     8581 agcaatttta ctagatgcaa tgacagatga aatgaatgct aaggatgaaa agtaagtaat
     8641 ggtagatata ataaagatat taacaaataa aaagtgttat ccaaataaga atagctgaaa
     8701 gttatcataa ttcatgaaac taataatgaa aacgagggag cagatgccaa gagacacaca
     8761 agtattaaat acatataatt tcgaagcaag tgttcattac tatatagatg acaaggtagt
     8821 atatcaaaca ttggttcaca aagatggtgc atggtcagtt ggtaaaatct attaagctac
     8881 attagttaca gatatcacaa actataatag ttaaacatag aaatatgtgt aaattgtgat
     8941 tgaaattatt caaaaacaca aaaatacgtg atgaaggaca aaatgatata gaaaataagt
     9001 atcaaacctt aataaatgat ttaattgata gtttaaaagt tataggaaaa atatataaag
     9061 aaataaaaac attaaaaaaa tataagatat gtttacaaat tactatcaga caatctcctt
     9121 atctaataga agagtcaatt aactaattga gtatctttaa attgaaatgt taggaagtga
     9181 tttaaatatg aaaacttaaa ttataaaaaa tcaatattaa tttattttta aaaaatagaa
     9241 aggagtgtat aagatttatt ttcaaagttt aaaaacaaga aaatcaattt aaatttcaga
     9301 aggaataaat gtggttatag aagtggattt attatcaaaa ataataatac taggaggttt
     9361 ttatgtcttt aatatctaaa gaagagttaa taaaactcgc atatagcatt agaccaagag
     9421 aaaatgagta taaaactata ctaactaatt tagacgaata taataagtta actacaaaca
     9481 ataatgaaaa taaatattta caattaaaaa aactaaatga atcaattgat gtttttatga
     9541 ataaatataa aacttcaagc agaaatagag cactctctaa tctaaaaaaa gatatattaa
     9601 aagaagtaat tcttattaaa aattccaata caagccctgt agaaaaaaat ttacattttg
     9661 tatggatagg tggagaagtc agtgatattg ctcttgaata cataaaacaa tgggctgata
     9721 ttaatgcaga atataatatt aaactgtggt atgatagtga agcattctta gtaaatacac
     9781 taaaaaaggc tatagttgaa tcttctacca ctgaagcatt acagctacta gaggaagaga
     9841 ttcaaaatcc tcaatttgat aatatgaaat tttacaaaaa aaggatggaa tttatatatg
     9901 atagacaaaa aaggtttata aattattata aatctcaaat caataaacct acagtaccta
     9961 caatagatga tattataaag tctcatctag tatctgaata taatagagat gaaactgtat
    10021 tagaatcata tagaacaaat tctttgagaa aaataaatag taatcatggg atagatatca
    10081 gggctaatag tttgtttaca gaacaagagt tattaaatat ttatagtcag gagttgttaa
    10141 atcgtggaaa tttagctgca gcatctgaca tagtaagatt attagcccta aaaaattttg
    10201 gcggagtata tttagatgtt gatatgcttc caggtattca ctctgattta tttaaaacaa
    10261 tatctagacc tagctctatt ggactagacc gttgggaaat gataaaatta gaggctatta
    10321 tgaagtataa aaaatatata aataattata catcagaaaa ctttgataaa cttgatcaac
    10381 aattaaaaga taattttaaa ctcattatag aaagtaaaag tgaaaaatct gagatatttt
    10441 ctaaattaga aaatttaaat gtatctgatc ttgaaattaa aatagctttc gctttaggca
    10501 gtgttataaa tcaagccttg atatcaaaac aaggttcata tcttactaac ctagtaatag
    10561 aacaagtaaa aaatagatat caatttttaa accaacacct taacccagcc atagagtctg
    10621 ataataactt cacagatact actaaaattt ttcatgattc attatttaat tcagctaccg
    10681 cagaaaactc tatgttttta acaaaaatag caccatactt acaagtaggt tttatgccag
    10741 aagctcgctc cacaataagt ttaagtggtc caggagctta tgcgtcagct tactatgatt
    10801 tcataaattt acaagaaaat actatagaaa aaactttaaa agcatcagat ttaatagaat
    10861 ttaaattccc agaaaataat ctatctcaat tgacagaaca agaaataaat agtctatgga
    10921 gctttgatca agcaagtgca aaatatcaat ttgagaaata tgtaagagat tatactggtg
    10981 gatctctttc tgaagacaat ggggtagact ttaataaaaa tactgccctc gacaaaaact
    11041 atttattaaa taataaaatt ccatcaaaca atgtagaaga agctggaagt aaaaattatg
    11101 ttcattatat catacagtta caaggagatg atataagtta tgaagcaaca tgcaatttat
    11161 tttctaaaaa tcctaaaaat agtattatta tacaacgaaa tatgaatgaa agtgcaaaaa
    11221 gctacttttt aagtgatgat ggagaatcta ttttagaatt aaataaatat aggatacctg
    11281 aaagattaaa aaataaggaa aaagtaaaag taacctttat tggacatggt aaagatgaat
    11341 tcaacacaag cgaatttgct agattaagtg tagattcact ttccaatgag ataagttcat
    11401 ttttagatac cataaaatta gatatatcac ctaaaaatgt agaagtaaac ttacttggat
    11461 gtaatatgtt tagttatgat tttaatgttg aagaaactta tcctgggaag ttgctattaa
    11521 gtattatgga caaaattact tccactttac ctgatgtaaa taaaaattct attactatag
    11581 gagcaaatca atatgaagta agaattaata gtgagggaag aaaagaactt ctggctcact
    11641 caggtaaatg gataaataaa gaagaagcta ttatgagcga tttatctagt aaagaataca
    11701 ttttttttga ttctatagat aataagctaa aagcaaagtc caagaatatt ccaggattag
    11761 catcaatatc agaagatata aaaacattat tacttgatgc aagtgttagt cctgatacaa
    11821 aatttatttt aaataatctt aagcttaata ttgaatcttc tattggtgat tacatttatt
    11881 atgaaaaatt agagcctgtt aaaaatataa ttcacaattc tatagatgat ttaatagatg
    11941 agttcaatct acttgaaaat gtatctgatg aattatatga attaaaaaaa ttaaataatc
    12001 tagatgagaa gtatttaata tcttttgaag atatctcaaa aaataattca acttactctg
    12061 taagatttat taacaaaagt aatggtgagt cagtttatgt agaaacagaa aaagaaattt
    12121 tttcaaaata tagcgaacat attacaaaag aaataagtac tataaagaat agtataatta
    12181 cagatgttaa tggtaattta ttggataata tacagttaga tcatacttct caagttaata
    12241 cattaaacgc agcattcttt attcaatcat taatagatta tagtagcaat aaagatgtac
    12301 tgaatgattt aagtacctca gttaaggttc aactttatgc tcaactattt agtacaggtt
    12361 taaatactat atatgactct atccaattag taaatttaat atcaaatgca gtaaatgata
    12421 ctataaatgt actacctaca ataacagagg ggatacctat tgtatctact atattagacg
    12481 gaataaactt aggtgcagca attaaggaat tactagacga acatgaccca ttactaaaaa
    12541 aagaattaga agctaaggtg ggtgttttag caataaatat gtcattatct atagctgcaa
    12601 ctgtagcttc aattgttgga ataggtgctg aagttactat tttcttatta cctatagctg
    12661 gtatatctgc aggaatacct tcattagtta ataatgaatt aatattgcat gataaggcaa
    12721 cttcagtggt aaactatttt aatcatttgt ctgaatctaa aaaatatggc cctcttaaaa
    12781 cagaagatga taaaatttta gttcctattg atgatttagt aatatcagaa atagatttta
    12841 ataataattc gataaaacta ggaacatgta atatattagc aatggagggg ggatcaggac
    12901 acacagtgac tggtaatata gatcactttt tctcatctcc atctataagt tctcatattc
    12961 cttcattatc aatttattct gcaataggta tagaaacaga aaatctagat ttttcaaaaa
    13021 aaataatgat gttacctaat gctccttcaa gagtgttttg gtgggaaact ggagcagttc
    13081 caggtttaag atcattggaa aatgacggaa ctagattact tgattcaata agagatttat
    13141 acccaggtaa attttactgg agattctatg cttttttcga ttatgcaata actacattaa
    13201 aaccagttta tgaagacact aatattaaaa ttaaactaga taaagatact agaaacttca
    13261 taatgccaac tataactact aacgaaatta gaaacaaatt atcttattca tttgatggag
    13321 caggaggaac ttactcttta ttattatctt catatccaat atcaacgaat ataaatttat
    13381 ctaaagatga tttatggata tttaatattg ataatgaagt aagagaaata tctatagaaa
    13441 atggtactat taaaaaagga aagttaataa aagatgtttt aagtaaaatt gatataaata
    13501 aaaataaact tattataggc aatcaaacaa tagatttttc aggcgatata gataataaag
    13561 atagatatat attcttgact tgtgagttag atgataaaat tagtttaata atagaaataa
    13621 atcttgttgc aaaatcttat agtttgttat tgtctgggga taaaaattat ttgatatcca
    13681 atttatctaa tactattgag aaaatcaata ctttaggcct agatagtaaa aatatagcgt
    13741 acaattacac tgatgaatct aataataaat attttggagc tatatctaaa acaagtcaaa
    13801 aaagcataat acattataaa aaagacagta aaaatatatt agaattttat aatgacagta
    13861 cattagaatt taacagtaaa gattttattg ctgaagatat aaatgtattt atgaaagatg
    13921 atattaatac tataacagga aaatactatg ttgataataa tactgataaa agtatagatt
    13981 tctctatttc tttagttagt aaaaatcaag taaaagtaaa tggattatat ttaaatgaat
    14041 ccgtatactc atcttacctt gattttgtga aaaattcaga tggacaccat aatacttcta
    14101 attttatgaa tttatttttg gacaatataa gtttctggaa attgtttggg tttgaaaata
    14161 taaattttgt aatcgataaa tactttaccc ttgttggtaa aactaatctt ggatatgtag
    14221 aatttatttg tgacaataat aaaaatatag atatatattt tggtgaatgg aaaacatcgt
    14281 catctaaaag cactatattt agcggaaatg gtagaaatgt tgtagtagag cctatatata
    14341 atcctgatac gggtgaagat atatctactt cactagattt ttcctatgaa cctctctatg
    14401 gaatagatag atatatcaat aaagtattga tagcacctga tttatataca agtttaataa
    14461 atattaatac caattattat tcaaatgagt actaccctga gattatagtt cttaacccaa
    14521 atacattcca caaaaaagta aatataaatt tagatagttc ttcttttgag tataaatggt
    14581 ctacagaagg aagtgacttt attttagtta gatacttaga agaaagtaat aaaaaaatat
    14641 tacaaaaaat aagaatcaaa ggtatcttat ctaatactca atcatttaat aaaatgagta
    14701 tagattttaa agatattaaa aaactatcat taggatatat aatgagtaat tttaaatcat
    14761 ttaattctga aaatgaatta gatagagatc atttaggatt taaaataata gataataaaa
    14821 cttattacta tgatgaagat agtaaattag ttaaaggatt aatcaatata aataattcat
    14881 tattctattt tgatcctata gaatttaact tagtaactgg atggcaaact atcaatggta
    14941 aaaaatatta ttttgatata aatactggag cagctttaac tagttataaa attattaatg
    15001 gtaaacactt ttattttaat aatgatggtg tgatgcagtt gggagtattt aaaggacctg
    15061 atggatttga atattttgca cctgccaata ctcaaaataa taacatagaa ggtcaggcta
    15121 tagtttatca aagtaaattc ttaactttga atggcaaaaa atattatttt gataatgact
    15181 caaaagcagt cactggatgg agaattatta acaatgagaa atattacttt aatcctaata
    15241 atgctattgc tgcagtcgga ttgcaagtaa ttgacaataa taagtattat ttcaatcctg
    15301 acactgctat catctcaaaa ggttggcaga ctgttaatgg tagtagatac tactttgata
    15361 ctgataccgc tattgccttt aatggttata aaactattga tggtaaacac ttttattttg
    15421 atagtgattg tgtagtgaaa ataggtgtgt ttagtacctc taatggattt gaatattttg
    15481 cacctgctaa tacttataat aataacatag aaggtcaggc tatagtttat caaagtaaat
    15541 tcttaacttt gaatggtaaa aaatattact ttgataataa ctcaaaagca gttaccggat
    15601 ggcaaactat tgatagtaaa aaatattact ttaatactaa cactgctgaa gcagctactg
    15661 gatggcaaac tattgatggt aaaaaatatt actttaatac taacactgct gaagcagcta
    15721 ctggatggca aactattgat ggtaaaaaat attactttaa tactaacact gctatagctt
    15781 caactggtta tacaattatt aatggtaaac atttttattt taatactgat ggtattatgc
    15841 agataggagt gtttaaagga cctaatggat ttgaatattt tgcacctgct aatacggatg
    15901 ctaacaacat agaaggtcaa gctatacttt accaaaatga attcttaact ttgaatggta
    15961 aaaaatatta ctttggtagt gactcaaaag cagttactgg atggagaatt attaacaata
    16021 agaaatatta ctttaatcct aataatgcta ttgctgcaat tcatctatgc actataaata
    16081 atgacaagta ttactttagt tatgatggaa ttcttcaaaa tggatatatt actattgaaa
    16141 gaaataattt ctattttgat gctaataatg aatctaaaat ggtaacagga gtatttaaag
    16201 gacctaatgg atttgagtat tttgcacctg ctaatactca caataataac atagaaggtc
    16261 aggctatagt ttaccagaac aaattcttaa ctttgaatgg caaaaaatat tattttgata
    16321 atgactcaaa agcagttact ggatggcaaa ccattgatgg taaaaaatat tactttaatc
    16381 ttaacactgc tgaagcagct actggatggc aaactattga tggtaaaaaa tattacttta
    16441 atcttaacac tgctgaagca gctactggat ggcaaactat tgatggtaaa aaatattact
    16501 ttaatactaa cactttcata gcctcaactg gttatacaag tattaatggt aaacattttt
    16561 attttaatac tgatggtatt atgcagatag gagtgtttaa aggacctaat ggatttgaat
    16621 actttgcacc tgctaatact cataataata acatagaagg tcaagctata ctttaccaaa
    16681 ataaattctt aactttgaat ggtaaaaaat attactttgg tagtgactca aaagcagtta
    16741 ccggattgcg aactattgat ggtaaaaaat attactttaa tactaacact gctgttgcag
    16801 ttactggatg gcaaactatt aatggtaaaa aatactactt taatactaac acttctatag
    16861 cttcaactgg ttatacaatt attagtggta aacattttta ttttaatact gatggtatta
    16921 tgcagatagg agtgtttaaa ggacctgatg gatttgaata ctttgcacct gctaatacag
    16981 atgctaacaa tatagaaggt caagctatac gttatcaaaa tagattccta tatttacatg
    17041 acaatatata ttattttggt aataattcaa aagcggctac tggttgggta actattgatg
    17101 gtaatagata ttacttcgag cctaatacag ctatgggtgc gaatggttat aaaactattg
    17161 ataataaaaa tttttacttt agaaatggtt tacctcagat aggagtgttt aaagggtcta
    17221 atggatttga atactttgca cctgctaata cggatgctaa caatatagaa ggtcaagcta
    17281 tacgttatca aaatagattc ctacatttac ttggaaaaat atattacttt ggtaataatt
    17341 caaaagcagt tactggatgg caaactatta atggtaaagt atattacttt atgcctgata
    17401 ctgctatggc tgcagctggt ggacttttcg agattgatgg tgttatatat ttctttggtg
    17461 ttgatggagt aaaagcccct gggatatatg gctaaaatat atgtttgata aaaaattatt
    17521 cctgtgctac taagaaatta tttttatata ataaatattg agatttaatt aaaagtcatg
    17581 tgttattgta atacatgact tttagttaaa atttttctat catttaataa tctattattc
    17641 ttgactattt tataataaaa ttcatatatg gaaatattaa tactaaataa ttaatagttg
    17701 ataaaaaata gataatatgc taaaagcaaa aactaattta gagccttgta actgtttatt
    17761 tgcaattata aaaacatctt taaacatatt gactataata taaaatatta actataatac
    17821 aaaacaatat taattaattt tctctacagc tatccctggt atagttatat ttccacccat
    17881 agttgattca taagttatag ttccagcact tatacctctt atagttatgt aatcatcctc
    17941 taatactctt gaaggagtta ttgatttttt ataactacat agtacaacct tatcataatt
    18001 tccagacaca gctaatctta tttgcacctc atcaccatct tcaataactt gaataacctt
    18061 accttcaaat tttacctttt tgtacttata atcatcaggt gttctagcta attggtcata
    18121 agtaatacca gtatcatatc ctttcttctc ctcttcttct tttttgcgtt gttcttcagc
    18181 ctttttagct tcttcagctt ttttagcttc ttcagcttta cgttgatttt cagcttcaat
    18241 agctttcttt tcgtcgtctt tcattttgaa ccatggttca gcatcagaca atttgctatt
    18301 taaagtttct atttctgttt tttgagaatc tataactgat gtttggttag aaatgacctc
    18361 ctcatggtct tcagaacaag ctggtgagga tatattgcca aaaaacacgc ctaaaataaa
    18421 tgccagtaga gcaataccct ttgtgctctt aaagaattta attattttct tagagcttcc
    18481 ttttccttca ttactaaatt cgttaccctc atttttttta gaaaacataa tacaatctcc
    18541 cttttattag atatatttta ttttaaaagt taaaaactta aaataactag ttgactaaaa
    18601 attatatatt catattttcc taaaatatat ttcccctaag cataatttta caaaataaag
    18661 taagaagatt caatatattt tgaaaaaata agataaaaat gtcagattat aatataattt
    18721 tcttgaaggt gaattttata tattaaatta aacataaagt attttatttg tataaaacta
    18781 tattatgatg taattaagtg actcagtgat ttagaggtgg taaaatatat atatatgaaa
    18841 gagcataaat aaattgatat aataaaaaat taaatattaa atattaacta taataaaaaa
    18901 atatctggta ataggtataa tataaaaaga atataccaga aagaaggtga agtatgggag
    18961 aactacaaaa aattccaggg gtagggaaag caacagaaaa atctttaatc atgttaggat
    19021 atacaactat taaatcactt aaagatgcaa acccagcaca aatgtatgaa aaggaatgtt
    19081 taatgcgtgg acagcacata gacagatgtc agttatatgt atacagatgt gcagtatatt
    19141 ttgcatcaac tgaaaatcca gaaccagaaa aattaaagtg gtggtattgg aaagattaaa
    19201 aaatcaaaaa agttagacat aaaaaagagt tgaatatccg ttttaaataa taaaaactaa
    19261 tactcaactc ttttttagtc gtaaatttta tgtaaatcta tttgtatggc taaatatacc
    19321 catcaataaa tgtataaata tactaatcaa caaatgacta aacatactac ctaacaaagg
    19381 attaaataaa ttccttaaca aagcattcta aaacaattaa ttagaaactg tttcttcaag
    19441 ccattttcta cattgctcaa tatttaccat agggtcaaaa ccttggtctt ttcccttatt
    19501 taaaagcata tcacaaggga aagtatcaca ttcaccacaa tgattaagtt ccttactttc
    19561 acagcaagtt ttaaccttac attctccacc ccaaaatggt ttttccatag ttgggcaacc
    19621 agtgcaattt acttgttctt tttttgtaca actgtcacaa cagacaccac atcttgattc
    19681 aaacatattc aaacatcctt tccattattt aaaaatatta taaaatgatt ttagatgaat
    19741 acaaaagtgc aaatagttga ttttaggtca tctaaatgtt aaacataaaa ttattagtac
    19801 tggtaaattt ataaaaacta ttccaaaaat ctttttgaat atttcaaaac acaataaatt
    19861 acttcaaatc cccttgaata tattttacag cattatagat tgctttaaat ctctttgaat
    19921 attctacaag actatagatt agtttaaatc cctttgaata tattttacaa cattatagat
    19981 tgttttaaat ctctttgaat attctacaag actatagatt agtttaaatc cctttgaata
    20041 tttcaaaaca ccatagatta ctttaaatcc ctttgaatgt tctataacac tataaattac
    20101 ttttaacttt tatataacca taaagttttt atctggcact ttaaatggag ttttatatca
    20161 aatttgcctt ccatcgaata accaaactta atttaattac acattccaag agtcaaatat
    20221 tcattcaata tatttgataa ttctatgtta tagctataat taaatataga ttattaaagt
    20281 taaatattta tttaatatat tgaatgattt t
//
LOCUS       DAEHWM010000078        19849 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.079, whole genome shotgun sequence.
ACCESSION   DAEHWM010000078 DAEHWM010000000
VERSION     DAEHWM010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19849)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19849)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19849
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.079"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(235..378)
                     /gene="scfA"
                     /locus_tag="KNP36_002760"
     CDS             complement(235..378)
                     /gene="scfA"
                     /locus_tag="KNP36_002760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="HBF0874620.1"
                     /translation="MENKHVKTLSQATLKQSAAKGGCGECQTSCQSACKTSCTVANQE
                     CER"
     gene            complement(444..806)
                     /locus_tag="KNP36_002761"
     CDS             complement(444..806)
                     /locus_tag="KNP36_002761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR04086 family membrane protein"
                     /protein_id="HBF0874621.1"
                     /translation="MGKSNYIFKGLGYAYIITLAVLLVYNLFLTFTDIGGDNITMVSS
                     FITTISAAIGGFYTSKHMKEKGLMYGLLVGLLYIVCIFLTVFLAQEKFVFEVGMIYKL
                     LLISAAGGIGGVLGVNFK"
     gene            complement(864..1157)
                     /gene="yajC"
                     /locus_tag="KNP36_002762"
     CDS             complement(864..1157)
                     /gene="yajC"
                     /locus_tag="KNP36_002762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HBF0874622.1"
                     /translation="MPQQQIIMSIGLWVVVIAIFYFLMIRPQKKKDKQLKEMRSSLSV
                     GDKVITIGGIVANVAKVEDDVVILELGPNRTKVPFEKWAIGTVKSKKEEIEED"
     gene            complement(1291..2412)
                     /gene="tgt"
                     /locus_tag="KNP36_002763"
     CDS             complement(1291..2412)
                     /gene="tgt"
                     /locus_tag="KNP36_002763"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HBF0874623.1"
                     /translation="MYAVRYELIKTCKQSGARLGRLHTPHGIIETPIFMPVGTQATVK
                     SMTPEELKEIGSQIILSNTYHLYMRPGHELIKRAGGLHKFMNWDKPILTDSGGFQVFS
                     LGPLRKIKEEGVEFRSHLDGSKHFLTPEKAMEIQNALGSDIMMAFDECAPYPSDREYV
                     KNSLERTTRWLKRCKDAHNNTDKQALFGIIQGGMYKDLREQSAKEITNIDLPGYAIGG
                     LSVGEPKPLMYDVLEHTTPLMPKDKPRYLMGVGSPDDLVEGVIRGVDMFDCVLPTRIA
                     RNGTAMTSQGKVVVRNATYAEDFTPLDPECDCYACKNYSRAYIRHLIKANEILGARLI
                     TTHNLHFLLNLMKQIRQAIMEDRLLDFRNEFFAKYGYEI"
     gene            complement(2491..2976)
                     /locus_tag="KNP36_002764"
     CDS             complement(2491..2976)
                     /locus_tag="KNP36_002764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874624.1"
                     /translation="MHSLQKQKKNNPILKIAFIFERVLAVVVLIAVFLGTIDVLRLMW
                     GAYIVDFQNPVQYSQLNDFLAQILLLVIGVELVVMLSLHIPGAFIEALLYAIARKMLL
                     LPKNEGMIDVLIGVIAIAGLFAIKKFLVTKDKSALNIMSIHDEEAIKEQQNKEDEDKS
                     I"
     gene            complement(2988..4013)
                     /gene="queA"
                     /locus_tag="KNP36_002765"
     CDS             complement(2988..4013)
                     /gene="queA"
                     /locus_tag="KNP36_002765"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HBF0874625.1"
                     /translation="MKTSDFKFDLPQELIAQVPIEDRASSRLMVLDKETGNIEHKVFR
                     DIIEYLNPGDCLVLNNTRVIPARLIGEKLETGGKIEFLLLKRTEEDTWQALVKPGKRA
                     KVGTKFSFGNGKLIGEVVDLSDEGSRIIKFHYDGIFEEILDELGNMPLPPYITARLDE
                     KERYQTVYSKHNGSAAAPTAGLHFTEELLNKIKEKGVDIAFVTLHVGLGTFRPVKVED
                     VLNHKMHSEYYMVSQEAADKINRAKENGKNVICVGTTSCRTIESACNEDGKMKETSGW
                     TEIFIYPGYKFKVLDKLITNFHLPESTLIMLVSAICGKDNVLNAYNEAVKERYRFFSF
                     GDAMIIK"
     gene            complement(4331..5350)
                     /gene="ruvB"
                     /locus_tag="KNP36_002766"
     CDS             complement(4331..5350)
                     /gene="ruvB"
                     /locus_tag="KNP36_002766"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HBF0874626.1"
                     /translation="MQGFEDENRIITSTMKMEDIDIENSLRPKTLEDYLGQEKSKEQL
                     SIFIEAAKSRNEQLDHVLLYGPPGLGKTTLASIIANEMGVNLRITSGPAIERAGDLAA
                     ILTNLNENDVLFIDEIHRINRSVEEVLYPAMEDFCLDIIIGKGPSARSIRLDLPKFTL
                     IGATTRAGMLTNPLRDRFGVICKLDYYTVDELSKIVLRSSSILDAEIQSNGALELAKR
                     SRGTPRIANRLLKRVRDFAQVRADGKITDKVAKDALELLGVDSLGLDFVDEKLLMTII
                     EKFRGGPVGLDTLAASIGEDRNTIEDVYEPYLLQLGFINRGPRGRVAMPLAYEHLKIP
                     YPNEK"
     gene            complement(5457..6059)
                     /gene="ruvA"
                     /locus_tag="KNP36_002767"
     CDS             complement(5457..6059)
                     /gene="ruvA"
                     /locus_tag="KNP36_002767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891076.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HBF0874627.1"
                     /translation="MYSYIKGTVEEIYIDSIVVENNGIGYKINVSSNTIMNLQVGEAT
                     KIYTKLIVREDDMSLCGFVSREELKMFELLTSVSKIGPKVALSILSFASPAQLGAYIL
                     SEDIGKLSKAPGVGKKTAERIVLELKDKVDKNNIEFEPTLLSQKPTLISQDESVDALV
                     ALGYTLSESKEAVQKCKKDGMNTEAIIKKALTYIMSKSLK"
     gene            complement(6052..6561)
                     /gene="ruvC"
                     /locus_tag="KNP36_002768"
     CDS             complement(6052..6561)
                     /gene="ruvC"
                     /locus_tag="KNP36_002768"
                     /EC_number="3.1.22.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="crossover junction endodeoxyribonuclease RuvC"
                     /protein_id="HBF0874628.1"
                     /translation="MIILGIDPGIAIVGYGIIEYKNSKFKAIDYGAVTTPAHMNISRR
                     LELVYKGIDTIVKNYNIDEVGMEELFFNKNVKTAITVAQARGVTMLACAHNGKPVYEY
                     TPLQVKQGVVGYGRADKAQVQQMVTSFLSLKKVPKPDDVADALAVAICHAHSNKLEKT
                     LKNIGGKYV"
     gene            complement(6873..7502)
                     /locus_tag="KNP36_002769"
     CDS             complement(6873..7502)
                     /locus_tag="KNP36_002769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874629.1"
                     /translation="MFEKKKKELFPWKISALILVGVFVLSSGVYIGTRLKHNGVQTGE
                     VVSTSANMNEKSKEAFGLNKNCEVWLQSEGENETNYKRTLTMAGIVPESLLDKTKSEI
                     VSYFKKEYPTKKIKSMDKNEIILVESKYSDNKDVQAMDVTIKGKYTIENDNGNIALYK
                     YDDSGSKTLVEKTKIRVDSLPKTVQDEIKKGVVMDTEEEAYSRLEDFAS"
     gene            7705..8028
                     /locus_tag="KNP36_002770"
     CDS             7705..8028
                     /locus_tag="KNP36_002770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1540 domain-containing protein"
                     /protein_id="HBF0874630.1"
                     /translation="MERINCNVINCSHNNSHICYADKIFINGEKAHNDRHTCCSSFLD
                     ESIYSNLSSNVNNKNCEELVCTVKNCKYNKDGSLCTLDNILVAPETDRVNLYIETCCS
                     SFECK"
     gene            8296..9150
                     /locus_tag="KNP36_002771"
     CDS             8296..9150
                     /locus_tag="KNP36_002771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874631.1"
                     /translation="MSTFYIQFLYFVIYSFIGWCCETTYCSVLQKQFVNRGFLNGPFC
                     PIYGFGALAIVATLTPFVHNIPLLFLFSIIITSIMEYCTSFILEKIFNMTWWDYSKHK
                     FNIHGRVCLENSLMFGVLSLIVMLIVHPIVVDFINSISKNVLFIFAISIEIYFVLDLV
                     ITVHTILQLNGKLKQINLIIKELKDKKEYYKLITQETIENKLESLVENRLDTLEDRFE
                     ILKEKENYRYAKNRIDELKNKLNTLLSNHKLLHRRIIKAFPNISSNKHTDILNKIKEN
                     IKSIKKDK"
     gene            complement(9336..10772)
                     /locus_tag="KNP36_002772"
     CDS             complement(9336..10772)
                     /locus_tag="KNP36_002772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyacid dehydrogenase"
                     /protein_id="HBF0874632.1"
                     /translation="MREVKPISIDILNTFKQVDEDRLNKLLADELKHLDRKIVVLDDD
                     PTGVQTVHDISVYTDWDKDSMEQGFNEKNSMFFILTNSRGFTVAQTTKAHKEISKNIV
                     DVSKKVNKDFIIISRSDSTMRGHYPLETNLLKSEVERLSGKLFQGEIIMPFFKEGGRF
                     TIDNVHYVKEGEILVPAGMTEFAKDKSFGYKSSDIGEWCEEKTNGKYKSSDMIYISSK
                     ELRELNIEAITEKLKKAEGFNKIIVNATDYVDVKVFTIAFIRAVNGGKEFMFRSAAAI
                     TKVLGGVSDKELLTKDELVSKGNTNGGIILVGSHVNKTTQQLEELKNCKYPIEFIEFN
                     QHLVLQENGLKNEVKRVIKVVEEKISSGKTVAVYTRRERFDLDTNDKDKQLMISVEIS
                     DAVTSIIGMLNVRPNFIIAKGGITSSDVGTKALRVKKATVMGQIKPGIPVWMTGKESK
                     FPNMPYIIFPGNVGEISTLRESVEILMG"
     gene            complement(10843..12225)
                     /locus_tag="KNP36_002773"
     CDS             complement(10843..12225)
                     /locus_tag="KNP36_002773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntP family permease"
                     /protein_id="HBF0874633.1"
                     /translation="MITGYGLLIAFVISIGILLVSIIKFKVNPFLALLITSIITGFMV
                     RMPINEISTTISTGFGNTLGSIGIVIGLGIIFGNILSESRATESIAKGLLAKTGEKNS
                     ALAVTTAGFLISIPVFMDAAFVIMMPIIKYVSRVTKKSLMVFVCALGVGTIVGHALVI
                     PTPGPLAVAANVNANVGSFILYSIIVAFPAALIGGWIYGKRFEKYPAYAIDENDREKN
                     LEQGKDSIKIEDDDSSKVPGFGISMFSLLFPILLILISNVFSMFLEKGSTMSGVLAFI
                     GDKNIAILLGILVAIGFLKKYINKPMGDVVIEAADSAGLILLITGSGGAFGSVINASG
                     IGNFLVDTMSGLSISVVVLGFLLSALLRISQGSATVALVTTSSILGPTILATGMSPVL
                     VGLAICAGGVGFSLPNDSGFWVLSRFSGLSVKDTLNSWTIGGTIAGVVAFIMVLLLSV
                     INGIIPLPGL"
     gene            complement(12361..13266)
                     /gene="garR"
                     /locus_tag="KNP36_002774"
     CDS             complement(12361..13266)
                     /gene="garR"
                     /locus_tag="KNP36_002774"
                     /EC_number="1.1.1.60"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-hydroxy-3-oxopropionate reductase"
                     /protein_id="HBF0874634.1"
                     /translation="MEGYKMKLGFIGLGIMGKPMAKNLLKDGCNLLVYDINKSAVDEL
                     ISCGAKYASVLEMGQECDIVFTILPNGTIVQDILFGMDGLAKTLKEGSIVVDMSSVTP
                     TESILCANKLKDMGLEFIDSPVSGGEPKAIDGTLAFMAGGKEEIYKKVEPFFNIMGSS
                     SILIGDNGSGSVTKLTNQVIVNLTIAAVSEAFVLAAKAGADPEKVYKAIRGGLAGSTI
                     LDVKIPMIMNRDFKPGGKISINLKDIKNVMQTAHNLDVPLPMTSQLLEIMQTLKVHGH
                     LEDDHSGIAQYFEKLAGVEIKKHDN"
     gene            13662..14333
                     /locus_tag="KNP36_002775"
     CDS             13662..14333
                     /locus_tag="KNP36_002775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0874635.1"
                     /translation="MATFKRLQEQAYDYLKELILSGEMIENEIYSETKLASEIGISRT
                     PIRDALQRLSQDGFIDIIPSKGFRIHQITANEIVEIFQIRSAIEGFCTFLITSQYKEA
                     RAVETISKLKHLLDKQKDILLGDKNLNSFAEYDTLFHTTIVSYAQNTEFDKMFNNYMY
                     RIKKLALDSLSHEGRLETTLKEHTDIFNNIANGCIEDIYRTTLIHMETPKYINLEDFC
                     NNKLF"
     gene            14436..14984
                     /locus_tag="KNP36_002776"
     CDS             14436..14984
                     /locus_tag="KNP36_002776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874636.1"
                     /translation="MIFLNEDVVTNETIDKDYAIEEVRMACKHFGDLYFYFSKVLFEE
                     FGEDKTSEILRKVLFERSEERAIAMRERAHENGDELIADNIISTTDVPFLGWVPEFEE
                     LHCPYGASWLLRFEENPWFKKFASLYCDVTDTTVAEVFTGDTSHKITKNILWGDKSCE
                     RIYFHDDKVSEGKYTYGNKNCK"
     gene            15246..15554
                     /locus_tag="KNP36_002777"
     CDS             15246..15554
                     /locus_tag="KNP36_002777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874637.1"
                     /translation="MFNKIYEKKEFIVFQVKKGYVVYNTRKSFEEGHTHLKHFEAAKT
                     AIDLAINKKIPRSKDGYYLTSLIRISDDGYYIDKLSELLYVREQKGKKEKYCNSGYQM
                     "
     gene            complement(15716..17506)
                     /locus_tag="KNP36_002778"
     CDS             complement(15716..17506)
                     /locus_tag="KNP36_002778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874638.1"
                     /translation="MKKSKGFKKTIGRLLPFVKKYKFSFIIAIICIISAATMNALAPK
                     TEGLIITQLTKDVISIAKGVPGASVNFDYVTKILVILACIYFANAIFTYTSSFLLTNA
                     IQNTMRDLRNEVENKIRRLPISYFDSNSFGDVLSRISNDVDTISNALQQSFMQIVNSI
                     LVIILALSMMFTINIYMALIALFIIPISYFVSKFVVKKSQSRFSLQQNALGKLNGKVQ
                     EMYTGFNEIKLYGKEEDSIKEFKKVNQELCENGFKAQFISSMMNPMVSLVTYFGIAAV
                     AVVGSIYAVSGGITVGNLQAFVRYIWQINQPLSQMTQLSTVIQSSFAAIERVFEILDE
                     EEEIPDVENPVKIENVKGNVTFEHVNFGYGENSTLIEDLNAEVKSGQMVAIVGPTGAG
                     KTTLINLLMRFYDVKKGAIKIDGVDIRDMKRKDLRSMFGMVLQDTWLFNGTIFENIEY
                     GRFGATKEEIIQAAKVANVHHFITTLPDGYNMFLNEEASNISLGEKQLLTIARAFISD
                     PSILILDEATSSVDTRLELMLQKAMRNLMNGRTSFVIAHRLSTIRNADLILVMNNGSI
                     IEQGNHDELMEKGGFYEKLYNSQFADKESE"
     gene            complement(17506..19233)
                     /locus_tag="KNP36_002779"
     CDS             complement(17506..19233)
                     /locus_tag="KNP36_002779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003496244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874639.1"
                     /translation="MKLILSYLKNYKLLIVLNILAIFSFALVELGIPTIIAKIIDNGI
                     ANQNIAYIKQMGIVIVIISIIGVVGSILLGYCSAKVSTSVTRDIRNDIFEKSQEFSHT
                     EYNKFGISSMITRTTNDAFQIQQFVNILLRTALLTPVMFIISIIMTIRTSVELSIVLA
                     ISVPFIIIGVAIIAKVSQAISSKQQKGLDKLNLISRENLTGIRVIRAFGNDDYETERF
                     EKTNTYYANVSKKLFKLMSITQPAFFLLLNIAVLAVFWISSEKINIGELQVGQLVAFL
                     EYLFHAMFSIMLFSMVFIMYPRAEVSANRIKELLNEEPLIKNPENGIKDTENKGIIEF
                     DNVTFTYPDGEASVLKDISFTAKTGETVAFIGSTGSGKSTLINLIPRFYDVTEGSIKI
                     NGVDIREYDLKALRKKIGFIPQKSLLFTGSIANNIRFGKHKAGESELEYSAKVAQAYE
                     FISKKPRKFDELISEGGANVSGGQKQRLSIARAIIRRPEIYIFDDSFSALDFKTDAIL
                     RAKLKKETKDAIVLIVAQRISSIIDADKIIVLNEGQVVGMGTHKELLKNCEIYYEIAT
                     SQLKKEELE"
     gene            complement(19478..19744)
                     /locus_tag="KNP36_002780"
     CDS             complement(19478..19744)
                     /locus_tag="KNP36_002780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase family protein"
                     /protein_id="HBF0874640.1"
                     /translation="MNLEPKKLIEQIGKEKDKKDIWIVGGGDIVKLFMKDNLIDDYYI
                     YILTIILGRGISLFKSGIDKTNLNFKKASNIGELVKLEYSKKQK"
BASE COUNT         6566 a         3429 c         2287 g         7567 t
ORIGIN      
        1 ttattctaat acatgtaatt gataaaaaat aaaatataag agtagctact ttaaaataaa
       61 tgctcttata tgattagata tttttgcata attaaacgat aagaaatcaa atttaatttt
      121 acataaatag aatatatatt tttatataat aattgaaaat aaaagaggat acctcataat
      181 gataaaagaa tcactttgag ataccctctt acaaacaact aaatcaataa ttttctatct
      241 ttcacactct tgatttgcaa ctgtacaaga agttttacaa gctgattgac aagaagtttg
      301 acactctcca catccacctt ttgcagcact ttgctttaaa gtagcttgag ataaagtttt
      361 tacatgttta ttttccattt tcaacgcctc catttctaat tgtttcctat tgattatatc
      421 ataaaactac tttaatataa actctattta aagttgacac ccaatacgcc tccaatgcct
      481 cctgctgctg atattaacaa taacttataa atcatcccta cttcaaatac aaacttttct
      541 tgtgctaaaa acacagtcaa aaaaatacat actatgtaca aaagtcctac taaaagccca
      601 tacataagtc ctttttcttt catgtgtttt gaagtgtaaa accctcctat agctgcagaa
      661 atagtagtta taaatgatga gaccatagtt atattatctc caccaatatc tgtaaatgtc
      721 aaaaataagt tatacactaa taaaacagcc aaagttatta tatatgcata tcctagacct
      781 ttaaaaatat aattagattt tcccataaaa aaacctcctc tcaaattaat atatattcga
      841 gaaaaggctt ttaaattact aatttagtct tcttctattt cttctttttt agatttaaca
      901 gttcctatag cccatttttc aaatggaact ttagttctat ttggtcctaa ttctaatatt
      961 acaacatcat cttcaacttt agctacatta gctactattc cacctattgt aatgaccttg
     1021 tctcctacac ttaggctact tctcatttct tttaattgtt tgtctttttt cttttgaggt
     1081 ctaatcatta ggaaataaaa gattgcgatt actactaccc atagacctat actcataatt
     1141 atttgttgct gtggcattaa tttttcactc ctttgtaaat tatactcttt tgtaaatcat
     1201 aataaatgtt tatataacaa tttactttct ctatctttga gtactattga atattatata
     1261 ttaaaatgat tataattaat agtgcaaaac ctatatttca tatccatatt ttgcaaaaaa
     1321 ttcatttcta aaatcaagta atctatcttc cattatcgct tgtcttattt gtttcattaa
     1381 atttaataaa aagtgaagat tatgagtagt tattaatctt gcacccagta tttcatttgc
     1441 ttttataagg tgtcttatat aagctcttga atagttttta caagcataac aatcacattc
     1501 agggtcaagt ggagtaaagt cttcagcata agttgcattt ctaactacta ctttaccttg
     1561 gctagtcatt gcagttccat ttctagcgat acgagtaggt aggacacaat caaacatgtc
     1621 tactcctctt ataacacctt ctactaagtc atctggacta ccaactccca ttaggtatct
     1681 tggtttatcc tttggcataa gtggagttgt atgctctaac acgtcataca taagtggttt
     1741 tggttctcca acactaagtc caccaatagc atatcctggt aaatcaatat tagttatttc
     1801 tttcgctgat tgttccctta agtctttata catcccacct tgtattatac caaataaagc
     1861 ttgcttgtcg gtattattat gggcatcttt acatcttttt aaccatcttg ttgttctttc
     1921 taaagaattt tttacatatt ctctatctga tgggtatggt gcacactcat caaatgccat
     1981 cattatgtct gaacccaatg cattttgtat ttccatagct ttttctggag ttagaaaatg
     2041 ttttgaacca tctaagtgtg acctaaattc tacaccttct tcttttatct ttcttaaagg
     2101 ccctagacta aatacctgga accctccact atctgtaagt attggtttat cccaattcat
     2161 aaacttatga agaccaccag ctctttttat aagttcatga cctggtctca tatataaatg
     2221 gtatgtgtta ctaagtatta tttgtgaacc aatctctttt aattcttctg gtgtcataga
     2281 ttttacagtt gcttgagttc caactggcat gaatattggt gtttcaataa tcccatgtgg
     2341 agtgtgtaat cttcctaacc ttgcaccact ctgcttacaa gtctttatca attcgtatct
     2401 tactgcgtac ataaagttct ccttaatcat atttatttct cattatttct taagatatat
     2461 ttgtaataag ctattcatat aatttattgt ctaaatagat ttatcttcgt cttctttgtt
     2521 ctgttgttcc ttaattgctt cttcatcatg aatactcatt atattaagag cactcttgtc
     2581 ttttgttact aaaaactttt ttatagcaaa tagtcctgct atagctataa ctcctattaa
     2641 aacatctatc ataccttcat ttttaggcag tagcaacatt tttctagcaa ttgcgtaaag
     2701 taatgcctca ataaatgctc ctggtatatg aagagatagc attactacaa gttcaacacc
     2761 tattactaaa agtaatattt gtgctaaaaa atcattaagc tgactgtatt gtactggatt
     2821 ttgaaaatca actatatatg ctccccacat aagtcttaga acatctatag ttcctaaaaa
     2881 tactgctatt agaactacta ctgctaaaac acgttcaaat ataaaagcaa tctttaatat
     2941 agggttattc tttttttgtt tttgtaaact atgcatctat tacctcccta ctttataatc
     3001 atagcatctc caaaactgaa gaatctatat ctttctttta ctgcctcatt atatgcattt
     3061 aaaacattat cctttccaca aatagcactt actaacatta ttagtgtaga ctctggtaag
     3121 tgaaaattag taataagttt atctaaaact ttaaatttat aacctggata tataaatatt
     3181 tctgtccatc cactagtttc tttcatcttt ccatcctcat tacaagctga ttctatagtt
     3241 ctacaactag tagtaccaac acatattaca ttttttccat tttcctttgc tctatttatt
     3301 ttgtcagctg cttcttggct aaccatataa tattctgaat gcatcttgtg atttaaaaca
     3361 tcctctactt ttactggtct aaaagttcct aagccaacat gtagagttac aaaggctata
     3421 tctacacctt tttcttttat tttatttaac aattcttctg taaaatgtaa tcctgctgta
     3481 ggtgctgctg ctgaaccatt atgctttgaa taaacagtct ggtatctttc tttttcatct
     3541 agtctagcag tgatatatgg aggtagtggc atatttccaa gttcatccaa tatttcttca
     3601 aaaattccat cataatggaa ttttataatt cttgaacctt catctgataa atctacaact
     3661 tctccaatta gctttccatt tccaaaagaa aatttagtcc ctacttttgc tctttttcct
     3721 ggttttacta aagcctgcca agtatcttcc tctgttcttt ttaataataa aaactctatt
     3781 ttacctccag tttcaagctt ctctcctatt aatctagctg gtataactct agtattattt
     3841 aatactaagc aatctcctgg atttaaatat tctattatat ctctaaatac tttatgttca
     3901 atattacctg tctctttatc taataccatc aatcttgagc tagctctatc ttctatagga
     3961 acttgagcta taagttcctg tggtaagtca aatttaaaat cacttgtttt caatgttaaa
     4021 cttcctctct taaaatttct ccagctacaa taatatcaaa aaaacaactt attttccaca
     4081 atattaccat aatctatcaa gaaattgcta tttttaacag acaccatatc cacaatatat
     4141 agatattttt ccacgatata catgccttat ccacaatata tagatacaat acacacaatt
     4201 tttatcgtgt ttatccacag tatctacaga tataattacc attttgtgga tatgtttgaa
     4261 tttttagcca ttttagaaat attttaattt aatgactctt ttattttata aatactcgta
     4321 taatctattt ttatttttca ttgggatatg gaatttttaa gtgttcatat gctaatggca
     4381 tagctactct tcctctagga cctctattta taaatcctaa ttgaagcaaa tatggctcat
     4441 atacatcttc tattgtattt ctatcttctc cgatagaagc tgccaatgta tctaaaccca
     4501 ctggtcctcc tctaaatttt tctattatag tcataagaag cttctcatct acaaaatcga
     4561 gacccaaact atcgactcct aaaagttcca gagcatcttt tgccacttta tcagttattt
     4621 ttccatcagc tctgacttgt gcaaaatctc taactctttt tagtaatcta tttgctatcc
     4681 ttggagtccc tcttgaacgt tttgcaagtt ctaatgctcc attagactgt atctctgcat
     4741 ctaagatgct tgaagaccta agtactattt ttgaaagttc atcaactgta taatagtcca
     4801 atttacaaat aacaccaaat ctatctctaa gtggatttgt aagcatacca gctcttgtag
     4861 tagctccaat aagtgtaaat ttaggaaggt caagtcttat gcttctagca gatggccctt
     4921 tccctattat tatatctagg caaaaatcct ccattgctgg atataaaact tcttcaacac
     4981 ttctattgat tctatgaatc tcatctataa ataaaacatc attttcattt aaattcgtaa
     5041 gtatggctgc caaatctcca gctctttcta ttgcaggtcc tgacgtaatt cttaaattta
     5101 cccccatctc attggctatt atacttgcta gtgtagtttt tccaagacct ggtggtccat
     5161 ataaaagcac atggtctaac tgctcatttc tcgatttagc tgcttctata aatatactaa
     5221 gttgttcttt ggatttttct tgacccaaat aatcttctaa agtttttggt cttaaactgt
     5281 tttctatatc tatatcttcc atcttcattg tagaagttat tatcctattt tcatcttcaa
     5341 aaccttgcat ttatacccct cctctcgtac ttttgaaaat ctactttata tattttcaaa
     5401 tttacataaa ctccttaaat attgttttaa aatccaaata ttataaaatc caaatactat
     5461 ttcaaggatt tactcattat atatgtaagt gctttcttta taatagcttc tgtattcata
     5521 ccatcttttt tacatttttg aactgcctct tttgattccg acaaagtata gcctaaagct
     5581 acaagtgcat ctacagactc atcttgtgat atcaaggtag gtttttgtga taataacgtt
     5641 ggttcaaact ctatgttatt tttgtctacc ttatccttaa gctctaagac gattctttct
     5701 gctgtctttt taccaacacc aggagctttg gataattttc caatgtcttc acttaaaata
     5761 tatgctccta actgtgctgg tgatgcaaat gatagtattg aaagcgccac cttaggtcct
     5821 attttagata cagatgttag taattcaaac atcttaagtt cttccctact tacaaaacca
     5881 caaagactca tatcatcttc tcttacaatt aatttagtat atatttttgt ggcttctccc
     5941 acttgtaaat tcattattgt attggatgat acatttattt tatatcctat cccattattt
     6001 tcaacaacta tactgtctat ataaatttct tctactgtac cttttatata actatacata
     6061 cttaccacct atattcttta gagttttttc aagtttgttt gaatgagcat ggcaaatagc
     6121 cacagctaaa gcatctgcaa catcatctgg ttttggaact ttttttagac ttaaaaatga
     6181 agttaccatc tgttgaactt gtgccttatc tgctctccca tatccaacta caccttgttt
     6241 tacttgaagt ggagtgtatt catatacagg cttcccatta tgagcacatg caagcatagt
     6301 aacacctcta gcttgtgcaa ctgttatagc tgtttttaca ttcttgttaa agaataattc
     6361 ttccattcca acttcatcta tattgtaatt ctttactatt gtatcaattc ctttatacac
     6421 aagttccaat cttctcgata tattcatatg ggcaggtgtt gtaactgctc cataatcgat
     6481 tgctttaaac ttgctatttt tgtattcaat tataccatat ccaactatgg ctatacctgg
     6541 gtcaatcccc aatattatca ttttttaaaa ttccccctaa aaataaaaga aataccaaaa
     6601 tgtatttctc ataaaaactt atgttctaaa tcattatatc ataaataata ttaacaaatc
     6661 ataaaatgct ctatgtaaaa tataaaatca aataaaaaag ttatatcaaa gcaagatttt
     6721 acctcaatat aacttttata tttattacaa ataaattatt gtatttttat aggaattaaa
     6781 tgtgactaca attttaatac taatctattt aatattaaat tatttattat taatttactt
     6841 agtatttaac ttaaaataat attaatttac tattaacttg caaagtcttc taatcttgaa
     6901 taggcctctt cttcagtatc cataactaca ccttttttga tttcatcttg aactgtttta
     6961 ggaagtgaat ctactcttat ttttgttttt tctactaatg ttttacttcc gctatcatca
     7021 tatttatata gtgctatatt tccattatca ttttcaatag tatatttacc ttttatagta
     7081 acatccattg cttgtacatc tttattatca ctatatttag attctaccaa tatgatttca
     7141 tttttatcca tactctttat ttttttagtt ggatattctt ttttaaaata tgatactatt
     7201 tctgacttcg tcttatctaa taatgactct ggaactattc ctgccattgt aagtgttctc
     7261 ttatagttag tttcattttc gccttcactt tgaagccaaa cttcacaatt tttatttaat
     7321 ccaaaagctt cttttgactt ttcattcata ttcgcactag tacttacaac ttcaccagtt
     7381 tgaactccat tgtgttttaa tcttgtccct atataaactc cgctacttaa tacaaatact
     7441 ccaaccagta ttaaggcaga tattttccaa ggaaataatt cttttttctt cttttcaaac
     7501 attgattacg cctccttttt ctattatttt ctccaagctg taagttttta tacaatttag
     7561 gtaaatttta gaagaaaata tatttatatt tcaaattact ctaagaatag atattttcta
     7621 aaaggtagtt ttctcttaat ggttatattc ttgtaattat atggacataa tttataataa
     7681 ataatcgttt aggaggtaat aactttggaa agaataaact gtaatgtaat taactgttca
     7741 cataacaaca gccatatatg ttatgcagat aaaattttta taaatggtga aaaagctcac
     7801 aatgacagac atacttgttg tagttcattt ttagatgaat ctatttatag taatttatct
     7861 agcaacgtta ataataaaaa ttgtgaggaa ttagtttgta ctgtaaaaaa ttgtaaatac
     7921 aacaaagatg gtagcttatg tacacttgat aatatattgg ttgctcctga aactgataga
     7981 gtaaaccttt atattgaaac atgttgctct agtttcgaat gtaaatagtc atagtataaa
     8041 tataagggtg tcaaatgtaa ttaaactaac atagtgtaga gtatctacaa ctattagttt
     8101 gattatactt gacaccctta tttattttaa ataaaatttc attattataa ccatgtttat
     8161 aatgttctaa ctgtaattaa atttgataaa tttctataaa ttggtataat caatatgtaa
     8221 attgaattta gtaaattaat cataaaaata aaatatcgag tatatagtgt tatactaact
     8281 agaaatgagg tgcttatgag tacattttat attcaatttc tttattttgt aatttatagc
     8341 tttataggat ggtgttgtga aactacatat tgttcagttt tacaaaaaca atttgtaaat
     8401 agaggttttt taaatggtcc attttgccct atatatggat ttggagcatt agcaatagtt
     8461 gctaccttga ctccttttgt acacaatatt cctttgttat ttttgtttag tataattata
     8521 actagcataa tggagtactg tacgagcttt attttagaaa aaatatttaa tatgacttgg
     8581 tgggattatt ctaaacataa atttaatatt catggaagag tttgtctgga aaactcactt
     8641 atgtttggtg tattatcatt gattgtaatg cttatagtac atcctattgt ggttgacttt
     8701 attaactcta tctctaaaaa tgtgctattt atatttgcta tatctataga aatttatttt
     8761 gttttagatt tagttatcac agtccataca attttacaat taaatggtaa gttaaaacaa
     8821 atcaatctta taattaagga attaaaagat aagaaagaat actacaaact tattacacaa
     8881 gaaactatag aaaacaaact tgaatcttta gttgaaaata gactggatac tttggaagat
     8941 aggtttgaaa tacttaaaga aaaagaaaat tatcgctatg ctaaaaatcg tattgatgag
     9001 ctaaaaaata aacttaatac tttgctgtct aaccacaaat tacttcatag acgtataatc
     9061 aaagcattcc ccaacataag ctctaataag catacagata ttttaaataa aatcaaagaa
     9121 aatattaaat caattaaaaa agataaataa taaaataaac acataagtta aataataaaa
     9181 atactaatac ataagattaa ggtttagaat attttttgta aaatactcta aaccctaatt
     9241 aatatactat tatttttaat cttaatttat aattttagtt tattttaatt ttaactcagt
     9301 aaatttaagc gtttaaactt caatacacta atatactacc ccatcaatat ctcaactgat
     9361 tctctaagtg tgctaatctc tcccacattt ccagggaaaa ttatatatgg catattagga
     9421 aatttgcttt ctttgcctgt catccatact ggtataccag gttttatctg tcccattact
     9481 gtagcttttt ttactcttag tgctttagta ccaacatcac tagaagtaat tccaccctta
     9541 gctataataa aatttggtct tacattaagc ataccaatta tactggtaac tgcatctgat
     9601 atttctacag aaatcataag ctgtttatct ttatcattcg tatccaagtc aaaacgctct
     9661 cgtctagtat aaacagcaac agttttacca ctgcttattt tttcctctac aacttttata
     9721 actcttttta cctcattttt tagaccattt tcttgaagaa ctaaatgttg attaaattct
     9781 ataaattcta tcggatattt acaattttta agttcttcta actgttgggt agtcttattc
     9841 acatgtgaac caacaagtat aattcctcca ttggtattac cttttgatac taattcatcc
     9901 ttagtaagta gttccttgtc actcactccg ccaagtactt ttgttatggc agcagcgctt
     9961 ctaaacataa attccttacc accatttact gctcgtataa acgcaattgt aaataccttt
    10021 acatctacat aatcggttgc atttacaata attttattga atccttcagc ttttttaagt
    10081 ttttctgtta tagcttcaat atttagctct ctaagttctt ttgacgaaat atatatcata
    10141 tcactagatt tgtactttcc atttgtcttt tcttcacacc actcacctat atcagatgat
    10201 ttatatccaa aagatttatc ttttgcaaat tcagtcattc ctgctggtac aagtatttct
    10261 ccttctttaa cataatgtac attatctata gtaaacctac caccttcttt aaaaaatggc
    10321 attattattt caccctgaaa taacttcccc gataatctct ctacttcgct ttttaataaa
    10381 ttagtttcaa gaggataatg tcctctcata gtagaatcac tacgacttat gattataaaa
    10441 tccttattaa ctttctttga tacatccaca atattctttg aaatttcttt atgtgctttt
    10501 gtagtttgag caacagtaaa tccccttgaa ttggtaagta taaaaaacat actatttttc
    10561 tcattaaagc cttgttccat actatcctta tcccaatcag tataaacaga aatatcatga
    10621 actgtttgta cacctgttgg gtcatcatct aatacaacaa tttttctatc taaatgctta
    10681 agctcatctg caagaagttt atttaatcta tcctcatcta cttgtttaaa agtattaagt
    10741 atatctatgc taattggttt tacttctctc atttaaaacg cccctttatg taatttgtat
    10801 agtctaaata taatttatat gatataaaca atagtttgtt atttatagac ctggaagtgg
    10861 tataattcca tttataacac taagcaataa aaccattata aatgctacaa ctccagcaat
    10921 ggttcctcca attgtccaag agtttaaagt atctttaact gataatccac taaatcttga
    10981 aagtacccag aatccagaat catttggaag ggagaaacca actcctccag cacatatagc
    11041 aagccctact aaaactggtg acattccagt tgccaaaatt gtaggtccta aaattgatga
    11101 tgttgttact aaggctacag tagcagaacc ttgagaaatt ctaagcaagg cacttaataa
    11161 gaatccaagt actacaactg atatactaag accagacata gtatcaacta agaagttacc
    11221 tataccactt gcatttataa cactgccaaa cgcaccacct gaccctgtta tcaataatat
    11281 tagccctgct gaatcagcag cttcaataac tacatctccc ataggtttat ttatgtattt
    11341 ctttaaaaat cctattgcca ccaatattcc aagaagtatt gctatgtttt tatctcctat
    11401 aaatgcaagt actccactca ttgtagaacc tttttctaag aacatactaa atacatttga
    11461 tataagtata agaagtattg ggaacaataa agaaaacata gaaattccaa aacctggtac
    11521 tttagaagaa tcatcatctt caatttttat gctatctttt ccctgctcta aatttttttc
    11581 tctatcattc tcatcaatag cataagctgg atatttttca aaacgttttc cataaatcca
    11641 tccacctata agagctgctg gaaaagcaac aattatagaa taaagtataa aactacctac
    11701 atttgcattt acatttgctg caactgccaa aggtcctggt gtaggtatta caagtgcatg
    11761 acctactata gtcccaactc ctaaggcaca tacaaaaacc attagagatt tcttagttac
    11821 tctcgaaaca tacttaatta taggcatcat tataacaaaa gctgcatcca taaaaactgg
    11881 aattgaaatt aaaaaacctg ctgtagttac tgctaaagca ctgttttttt ctccggtctt
    11941 agctaacaac ccctttgcaa tagattctgt tgctcttgat tctgaaagaa tatttccaaa
    12001 tattattcca agtccaatta caatacctat actacctaat gtatttccaa atccagtcga
    12061 tattgtggtt gatatttcat ttataggcat tctaaccata aagcctgtaa ttatagatgt
    12121 tatcagtaat gccaaaaacg gatttacttt aaatttaata atcgatacaa gtaaaattcc
    12181 tatagatata acaaatgcta tcaaaagtcc atatcctgta atcataatct ttaccccttt
    12241 atcattctac tttattattt atcaatttta tttttctttt actatgataa cttaacctcg
    12301 ctgtatttat ataatctaat cctaataata tgtatttaat tatattgata tatttaaata
    12361 ttaattatcg tgttttttta tttcaacacc tgccaacttt tcaaaatact gtgctattcc
    12421 actatggtca tcttccaaat gtccatgtac ttttaatgtc tgcataattt ctaataattg
    12481 acttgtcata ggtagtggta catctaaatt gtgtgctgtt tgcattacat tcttaatatc
    12541 tttcaaatta atagatattt ttccacctgg tttaaaatca cgattcataa tcattggtat
    12601 cttcacatcc aatattgtac taccagctag gcctcctctt attgccttat atactttttc
    12661 tgggtctgca cctgcttttg ctgcaagtac aaatgcctca gaaactgctg ctatcgtcaa
    12721 attaactatt acttggtttg taagttttgt aacacttcca ctaccattat ctccaattaa
    12781 aatagatgag cttcccatta tattaaaaaa tggctctact ttcttataaa tttcttcctt
    12841 accaccagcc ataaaagcaa gtgtaccatc aatcgctttt ggctcccctc cacttactgg
    12901 tgagtctata aattctaagc ccatatcttt taatttattt gcacacaata ttgattctgt
    12961 aggagtaact gaactcatat cgactactat acttccttct tttaaagttt ttgccaatcc
    13021 atccatccca aacaatatat cctgcacaat agttccattt ggaaggattg taaatacaat
    13081 atcacattct tgacccattt ctaaaacact tgcgtatttt gctccacatg atataagttc
    13141 atccacagca gatttattaa tgtcatacac caaaagatta catccatctt ttaataaatt
    13201 ttttgccatt ggctttccca ttatccctaa tccaataaat cccaatttca ttttataacc
    13261 ctccatatct tcacattttt gaaaacgttt tttatgtttt agagtatact acataccagt
    13321 ataccggtca atataaaata taaaagtatt tattttaaca ataaatagta atttttaaag
    13381 tcatttatta tatttagtca tcctatataa gttttaatac atactattgt tttcaaatat
    13441 aatatactac ttttacagtt ttgtatttta actaatttca attagtttta attaatctgc
    13501 ctttaatgtt aatcatgctt cacacttcaa taatttttta tattttttaa tcttatctgc
    13561 aatttaaatt gcaaaagatt gaccttattt tcactatgtt gtatgcttaa aattatataa
    13621 gtttttgtat ttttatattg tttagggggg tattattaag tatggctaca tttaaaagat
    13681 tacaagaaca agcatatgac tacttaaaag aattgatact atctggagaa atgatagaaa
    13741 atgaaatata ttctgaaaca aaacttgcta gtgaaatagg tatctctaga acacctataa
    13801 gagatgctct tcaaagactt agtcaagatg gatttataga tataatccca agcaaaggat
    13861 ttagaatcca tcaaattaca gcaaatgaaa ttgtagagat attccaaata cgctctgcaa
    13921 tagaaggatt ttgtactttt ttaattacaa gtcaatacaa agaagctaga gcagtagaaa
    13981 ctataagtaa attaaaacat cttttagata aacaaaaaga tattttatta ggtgataaaa
    14041 atttaaactc atttgcagaa tacgatacat tatttcacac aactatagtt tcatatgctc
    14101 aaaatactga atttgacaaa atgtttaaca attatatgta cagaataaaa aaattagctc
    14161 tcgattcatt gtcacatgaa ggaaggcttg aaacaacatt aaaagagcac acagatattt
    14221 ttaataatat tgcaaatgga tgtattgaag atatttacag aactactctc attcatatgg
    14281 aaactcctaa atacattaat ttagaagatt tttgtaacaa taagttattt tagtattata
    14341 ctttcattta ttaaaaatat atctatctca aattaatttc ctaatttata aaaaatattc
    14401 tataattata ttgtaactaa tacttattct aaggagtgat ttttttgaac gaagatgttg
    14461 taactaatga aactattgac aaagattatg ctattgaaga agttcgtatg gcatgcaaac
    14521 attttggtga tttatatttt tatttttcca aagtgttatt tgaagagttt ggtgaagata
    14581 aaactagcga aatattaaga aaagttttat ttgaaaggtc tgaagaaaga gctattgcta
    14641 tgagagagag agctcatgaa aatggagatg aattaatcgc agacaatatt attagcacaa
    14701 ctgatgttcc atttctagga tgggttcctg aatttgaaga gttacattgc ccctatggag
    14761 cttcttggct tttaagattt gaggaaaatc cttggtttaa aaaatttgct tctctttact
    14821 gtgatgttac agatactact gtagctgaag tatttacagg agatacgtcc cataaaataa
    14881 caaaaaacat tctatgggga gataaaagtt gtgaaagaat atatttccat gatgacaagg
    14941 tatctgaagg taaatatact tatggaaata aaaactgtaa ataaatgatt taaattttct
    15001 atattcatat actatatttt gtactttttc atataaatat tataactagt cttttatttt
    15061 acttttgttt aacctaaaga taatttactt ttaatctata tgaattatca tataaataat
    15121 cagaaagtta tctttataaa ttatagtttt agatttataa tttataaaat atttatgttc
    15181 tttgtaaaat tttttagaag cttctaatgt tatgctataa aactatcttg agaagggctg
    15241 attgaatgtt taataaaata tatgaaaaga aagaatttat agtttttcaa gttaaaaaag
    15301 gttatgtagt ttataatact agaaagagtt ttgaagaagg tcatacacat ttaaagcatt
    15361 ttgaagcagc aaagacagct attgatttag caataaataa aaagattcct agaagcaaag
    15421 atggatatta tctgactagt ttaattcgca taagtgatga tggttattac attgataagt
    15481 taagcgaatt gttatatgtt agagaacaaa aaggtaaaaa agaaaagtac tgtaattctg
    15541 gttatcagat gtaacaagac tagttgtgaa ttataagtac caatcataag tacctttagt
    15601 cttaaaatca aagagtatca gtaaatctat aaaaaaacaa cttactgata ctctttttaa
    15661 ttatatgatt aatatttgaa tttgatacaa aattttatac aaaagtttat gttatctatt
    15721 ctgattcttt gtctgcaaat tggctattat aaagcttctc ataaaatcca cccttttcca
    15781 ttaattcatc atgattcccc tgctctataa tacttccatt attcataact aaaatcaagt
    15841 cagcattgcg aattgtagaa agtctatgtg ctataacaaa actagttcta ccattcataa
    15901 gatttctcat tgctttttga agcataagtt ccagcctagt atcaacagaa ctcgtagctt
    15961 catcaagtat caatattgaa gggtctgata taaaagctct agctatggtt aaaagctgtt
    16021 tttcccctag agatatatta gatgcttctt catttaaaaa catattgtat ccatctggaa
    16081 gagtggttat aaagtgatga acatttgcta cttttgctgc ttgtataatt tcttctttag
    16141 tagccccaaa tctaccatat tctatatttt caaaaatggt tccattaaat aaccatgtat
    16201 cttgaagcac cataccaaac attgaacgca aatctttacg tttcatatct cttatatcta
    16261 ctccatcaat tttaatagca cctttcttta catcataaaa cctcatcaat aagtttatta
    16321 atgttgtttt acctgctcca gtaggtccaa caatagctac catctgacca ctttttactt
    16381 ctgcatttaa atcttctatt aaagttgaat tttctccata tccaaaatta acatgctcaa
    16441 atgtaacatt tccttttaca ttttctatct taactggatt ttcaacatca ggtatttcct
    16501 cttcttcgtc taaaatttca aatacacgtt ctatagctgc aaaagaagat tgtattactg
    16561 tagataactg agtcatttgt gaaagtggct gatttatctg ccatatataa cgcacaaatg
    16621 cttgtaaatt tcctactgtt attcctccac ttactgcata tatagaaccg acaactgcca
    16681 cagctgcaat tccaaagtaa gttactaatg aaaccatagg attcatcata cttgatataa
    16741 attgtgcctt aaatccattt tcacaaagtt cttgatttac ttttttaaat tcttttatag
    16801 aatcttcttc tttaccatat agttttattt cattaaatcc agtatacatt tcttgtactt
    16861 ttccatttaa ttttccaaga gcattttgtt gcaatgaaaa tctactttga gattttttta
    16921 ctacaaattt agatacaaaa taactaattg gaattataaa aagagctata agagccatat
    16981 atatattaat tgtaaacatc attgaaagtg ccaaaattat gactaagatt gagtttacaa
    17041 tttgcataaa actctgctgc aatgcatttg atattgtatc tacatcattt gatatacgac
    17101 ttaatacatc tccaaaacta ttactatcaa aataactaat aggcaatctt cttattttat
    17161 tttcgacttc atttcttaaa tctctcattg tgttttgaat agcattcgta agtagaaaac
    17221 ttgaagtata cgtaaaaatt gcattggcaa aatatataca tgctaaaatc accaatattt
    17281 ttgttacata atcaaaattt acggaagccc ctggtactcc ttttgcgata ctaattacat
    17341 ctttagtcaa ttgtgttatt atcaatcctt cagttttagg tgcaagtgca ttcatagtag
    17401 ctgctgaaat tatacatata atagctataa taaaggaaaa tttatatttc tttacaaatg
    17461 gaagaagtct accaattgtt ttcttaaaac ctttagactt tttcattatt ctaattcctc
    17521 cttttttaac tgagatgttg caatttcata gtatatttca cagtttttta ataattcttt
    17581 atgagttccc attcctacaa cttgtccttc attgagtact ataatcttat cagcatcaat
    17641 aatagaacta attctctggg caacaatcaa tacaattgca tcttttgttt ccttcttcaa
    17701 tttagcacga agtattgcat cagttttaaa gtcaagtgca gaaaaactat catcaaaaat
    17761 gtatatttca ggtcttctta taatagccct tgcaatagaa agtctttgtt tttgacctcc
    17821 tgatacattt gctccacctt cactaatcaa ttcatcaaac tttctaggtt tttttgatat
    17881 aaactcatat gcttgtgcaa cttttgcgga atattctaat tctgactctc ctgccttatg
    17941 tttcccaaat ctaatattat ttgctatgct accagtaaaa agcagtgatt tttgaggtat
    18001 gaatcctatc ttttttctta aagcttttaa atcatattct cttatatcta ctccatttat
    18061 cttaatgcta ccttctgtta catcataaaa tctaggtatc aagttaatta gagtactttt
    18121 cccactacca gtacttccta taaaagcgac tgtttcacct gtttttgcag taaatgaaat
    18181 atccttaagt acagaagctt ctccatctgg ataggtaaaa gttacattat caaattctat
    18241 gataccctta ttttcagtat ccttaattcc attttcagga ttttttatca atggttcttc
    18301 atttaatagt tcttttattc tatttgcaga tacctctgct cttggataca taataaatac
    18361 cattgaaaaa agcataattg aaaacatggc atggaaaaga tattccaaaa atgcaaccaa
    18421 ctgtccaact tgaagctctc caatatttat cttctcactt gaaatccaaa atacagccaa
    18481 aacagctata tttaatagta aaaagaatgc tggttgagta attgacataa gcttaaatag
    18541 tttcttagaa acattagcat aatatgtatt tgttttttca aatcgctctg tttcataatc
    18601 atcatttcca aaagctctaa ttactcttat tccagttaaa ttttctctcg atataaggtt
    18661 taatttatct agtccttttt gttgttttga agatattgcc tgagatactt ttgctattat
    18721 tgctactcca ataattataa aaggtactga tatagccaat actatagaaa gttccacact
    18781 tgttctaatt gtcattatta tacttataat gaacataact ggagttaata aggcagtcct
    18841 tagtagtata ttaacaaatt gttgaatttg aaatgcatca ttcgttgttc ttgtaatcat
    18901 tgaagaaatt ccaaatttat tgtattcagt atgtgaaaat tcttgtgatt tctcaaatat
    18961 gtcatttctt atatctctgg ttacacttgt tgatacctta gcagaacaat aacccaacaa
    19021 tatactacct acaaccccta taatagaaat aataacaatc actattccca tttgttttat
    19081 gtaagctata ttctgatttg caataccatt gtcaattatt ttagctatta tagttggaat
    19141 ccccaactcg actaatgcaa aactaaatat agccagtatg tttaatacta ttaataactt
    19201 ataattcttt aaataactta aaattaattt catatttttc tcctttctta atttttgaga
    19261 tagtgtaatc atgtaataat actaaattta taaatgctta attttataaa aaaaggagaa
    19321 aagagttaac gcactctctt ctccagcata ttctttttaa tacaccctcc gacaagtcgc
    19381 ttatatgtta acatatttga caagtaatgt caattcatat agccaaaagt cttttaaatg
    19441 cttcgtttca taacattgta acaaattggc atgtaattta tttttgtttt ttactgtatt
    19501 ccaattttac aagttctcca atattactag ctttcttaaa attcaaatta gtcttatcta
    19561 taccagactt aaatagtgaa atccctctcc ccaatattat tgtcaatata tatatataat
    19621 aatcatcaat taagttatct ttcataaata attttactat atcgcctcca ccaactatcc
    19681 aaatatcttt tttatccttc tcttttccaa tttgctcaat taatttttta ggttctaaat
    19741 taatttatag tgtgattatt ctatgtaaac atcacttttt tactcattca ataataccct
    19801 attaataaat cctcaaacta atttaaataa actttgtata aaattaaaa
//
LOCUS       DAEHWM010000079        19542 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.080, whole genome shotgun sequence.
ACCESSION   DAEHWM010000079 DAEHWM010000000
VERSION     DAEHWM010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19542)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19542)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19542
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.080"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(201..584)
                     /locus_tag="KNP36_002781"
                     /pseudo
     CDS             complement(201..584)
                     /locus_tag="KNP36_002781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431032.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
     regulatory      810..907
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            962..1138
                     /locus_tag="KNP36_002782"
     CDS             962..1138
                     /locus_tag="KNP36_002782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874641.1"
                     /translation="MFGNKMDKCTHVLTAYISSSYDYCNFLDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     gene            1364..1564
                     /locus_tag="KNP36_002783"
     CDS             1364..1564
                     /locus_tag="KNP36_002783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003723180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBF0874642.1"
                     /translation="MNNGIVKWFNNEKGFGFISMEGRDDVFAHFSAIQTSGFKSLEEG
                     QQVSFDIVKGARGPQAENITIL"
     gene            2569..3414
                     /locus_tag="KNP36_002784"
     CDS             2569..3414
                     /locus_tag="KNP36_002784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0874643.1"
                     /translation="MNIIKSITLLLTLLIVILMTGCSPRESASEVAKKYIDKMNSGDY
                     ETAYSLLSKDSKKKISIENLEEFQNILVSTKRIISYKIGKEKIIKKYKHDGKEYKNVV
                     KLEETFNIKNLLYKKDDSLKVNRYFVVENNKYKLLLYESFKKEFGINSMDLAQLKLND
                     FGLKYFKEVDLILKKAIAINPTDSKLYYAQACNYMNFDGFPGYSDTTYNALDSINKSL
                     KYLDKNDSDYKKNASNIYNLKGVILMFHKRFDEAQQYLNKALYFNKDNEDPKYNLNTI
                     KKHLN"
     gene            complement(3638..3802)
                     /locus_tag="KNP36_002785"
     CDS             complement(3638..3802)
                     /locus_tag="KNP36_002785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874644.1"
                     /translation="MFGKPKESVRFLDFNDVAEKFGEKKAVAIFDAIAGKKSKEHIIK
                     DIEKLVKNEV"
     gene            complement(4344..4676)
                     /locus_tag="KNP36_002786"
     CDS             complement(4344..4676)
                     /locus_tag="KNP36_002786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HBF0874645.1"
                     /translation="MNTREMKEYRGFYNKKLSETDEFFRVFGSLDDKTYSEGAISKKN
                     KELMGLAISILSRCDECICYHIEGCINSGASKDEIIEAIKIGVIGGGSITYPNARFAI
                     KILEEFNI"
     gene            complement(4920..5561)
                     /locus_tag="KNP36_002787"
     CDS             complement(4920..5561)
                     /locus_tag="KNP36_002787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SdpI family protein"
                     /protein_id="HBF0874646.1"
                     /translation="MKKAINKQFILSTLICFIPFIVSIYFYNRLPNEVAIHFDNYGNP
                     DNYAPKVIAAFGVPLLMLCIHLYTWFRLENEPKKANFSNVIQNLSKWGVAILSVIIQI
                     MMVLYSTGVSLESNFYTGLILGIIVILFGNYLPKCKRNYSVGIILPWTLNDEDNWNKT
                     HHLAGWIWLIGGILLIINAFINIPFYNIFVIFVIVILPFIYSYLMYKISGKNN"
     gene            complement(5542..5835)
                     /locus_tag="KNP36_002788"
     CDS             complement(5542..5835)
                     /locus_tag="KNP36_002788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBF0874647.1"
                     /translation="MGFPETFKALSDPIRREILVMLRENKMSAGEISEKFNMTNATIS
                     YHLSQLKKAGLIFETKYKNFIFYEINISVFEEVMLWFSQFMEKGEKDNEKSDK"
     gene            6228..6287
                     /locus_tag="KNP36_002789"
     CDS             6228..6287
                     /locus_tag="KNP36_002789"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HBF0874648.1"
                     /translation="MTEYIYYYNNKRIKKINLA"
     gene            complement(6803..7555)
                     /locus_tag="KNP36_002790"
     CDS             complement(6803..7555)
                     /locus_tag="KNP36_002790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TSUP family transporter"
                     /protein_id="HBF0874649.1"
                     /translation="MFSVIFLCIGGFLAAFVDSIAGGGGLISMPVLMAIGVPVHLAIG
                     TNKFAASAGCISSAYRYAKSGKINNNLLKKLVPFTIIGSVLGVRCVLSISEEILNVLV
                     VVMILIVAIYTFISKNLGQEDNFEAVNKKNLRLGMLMALIMGFYDGFFGPGTGTFLTF
                     GFIKIYGYDFLHASANTKILNLTSNITSLLLFMINGQVDYKIAIVFALVMIMGAYVGA
                     KVAIKKGSKMIKPIFLVMALFMVVKLVYQTLV"
     gene            complement(7614..9269)
                     /locus_tag="KNP36_002791"
     CDS             complement(7614..9269)
                     /locus_tag="KNP36_002791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0874650.1"
                     /translation="MEYFSESNNEVQKFDWGEVMWIHEPSKTQFNRLSAGIVRFFPGN
                     YQEKHFHLSEEQLLYVIQGEGIQIIDGKKVNIKETSIVYCPPYSEHEIINTGKIDLVI
                     LITYVPHKFSSLRQIPIVFSENNIQELVNVNIIENLANQISNILKLRISVYDLKYKEI
                     FETKKENKFCDICKNIKQCTKKLVKSINNDNFEKVYHCEYGVSSLEIPIVLEENIVGY
                     IECGNFIVYKSIDIDKNLSELSSSSGIDIKYINKIYNEFPLNPKSRLYVLKENLLMMS
                     EFIQEIAKRNFFENQLSIKDEEILKSRKENIRLEEALKKANSRLLEEEYIINPIDMFN
                     NSSKEYPFELELYIEKEIKNMNLEGVYNLIDTNKLRYNDVRDTIQEMIFVLSRTVLRD
                     LEDLKLISYLRNKYNKKISLVNSDEDLWNVLFEFSKECIDKNRAFWRKDKGNLIENIN
                     EYIKKYYKENINLNSISDVFFISPNYLSSIFNERNKVSITEYINLLRIEESKKYLLDR
                     SMSISDICKKVGFNNSSYFSQIFKKFNSITPNEYRKNMLDNKY"
     gene            complement(10542..11621)
                     /locus_tag="KNP36_002792"
     CDS             complement(10542..11621)
                     /locus_tag="KNP36_002792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0874651.1"
                     /translation="MILITLCILVAVFVLAFAGLRLIAPTIIRTSHKIEAPGIDRMEM
                     VEIGGIQQALYIRGQNADNPIILWVHGGPGNSMMPFLHLYQYEWENDFTVVNWDQRNV
                     GKTYFANDPAAVLQTMSAERVLQDVHEVTAYLKQEFNKEKIILIGHSWGTVLGTMAVQ
                     TYPEDYSAYIGIAQTVNMVDNERVGYEKTLEMVKAAGKQKDIKALEAIAPYPPAKYGP
                     SYLAALMTVRTYQSKYGLSINMDLGNIISILATPYYSLRELKNTAIFNPNAIDNQGDV
                     LRFLVEEADIRNYGVDYQVPVYYIMGENDYNSPYLPAKKFFDEIVAPDKQIFFIPDAD
                     HLPFLSKKAEFDCVLLEEIAPKLAK"
     gene            complement(11705..12361)
                     /locus_tag="KNP36_002793"
     CDS             complement(11705..12361)
                     /locus_tag="KNP36_002793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0874652.1"
                     /translation="MTRKNNPKQAIENIITISAKLFAEKGYDKTSMQNIVDASGMSKG
                     GIFHHFSSKEDIFNVVMERRFEQIIETVNQWLGEMHGLTAKEKLRSLVRRHLTDEVIK
                     ESSNMITSAIESPHIILAFTQDNLKKLAPILANVLREGIEDRSIITEFPDECAEVILL
                     LFNFWCDTDVFQGDFPTLRKRFQFLQFLMRQIGVDILEDEIIESINIFYERKPMGQVE
                     "
     gene            12683..12889
                     /locus_tag="KNP36_002794"
     CDS             12683..12889
                     /locus_tag="KNP36_002794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874653.1"
                     /translation="MISHAAEICKKYKMPFIIFPTIEKKSIEEWVNIGANMLCLAQDT
                     TFITYVINQLLSFYNEIVPIQKQH"
     gene            complement(13042..13470)
                     /locus_tag="KNP36_002795"
     CDS             complement(13042..13470)
                     /locus_tag="KNP36_002795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HBF0874654.1"
                     /translation="MSKIYIVYWSGTGNTEKMANFVAEGVKLKGKTPEVLDVSLLKPS
                     DLKEEDKFALGCPSMGAEQLEEGYMEPFVSELESMVSGKQIGLFGSYGWGNCEWMRDW
                     EERMQNAGATIIGGEGITAMEDPNEEAKDECIELGKTLAE"
     gene            complement(13946..14884)
                     /locus_tag="KNP36_002796"
     CDS             complement(13946..14884)
                     /locus_tag="KNP36_002796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBF0874655.1"
                     /translation="MNKRMKLIPYEINENLRGAKNKFPYGIKQMNARGMWDEGYTGKN
                     IVVGIIDTGCDISHPLLKGKIIGGANFSDDSNGNKNIYEDFNGHGTHVAGIIAASNYN
                     NEVMGVAPDCKLLIAKALNKDGTGTYQSIINAINFAVNNKVDIISMSLGGNKDDKNLK
                     NAVMQAVKNNISVVCAAGNNGDGDSSTSEYSYPASYAEVIEVGAINENYLVEKFSNSN
                     TTIDLVAPGRNIISTYMDNKLAIMSGTSMSAPYVSGSLALIKEWAREEFERDLDEAEL
                     YAQLIKCTRALGIPRTEQGNGYLYLNLYKYKNNSKR"
     gene            complement(15398..16210)
                     /locus_tag="KNP36_002797"
     CDS             complement(15398..16210)
                     /locus_tag="KNP36_002797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0874656.1"
                     /translation="MFYNAKSCQMMIGSNTVNYIEFGSGKKTLIILPGLGDGLFPLHG
                     KIQAIAFAFRYKQFTKDYKVYVFSRKNQITEKYSTRDMAKDQADIMKKLGIMKAEVMG
                     VSQGGMIAQYLAIDYPELVEKLVLAVTSSKQNDTIQNVICSWIDMAKKQNYNDLMIDT
                     AKKSYSERYLKKYQLFIPFLGKVGKPKDFKRFIIQATSCIEHNAFSELNKITCPTLII
                     GGANDKIVGNNASFHLVEKIKKSEIFIYEGLGHATYEEAQDFNERVLEFLNK"
     gene            complement(16236..16865)
                     /locus_tag="KNP36_002798"
     CDS             complement(16236..16865)
                     /locus_tag="KNP36_002798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0874657.1"
                     /translation="MNREEKSKNSKEKIIQSAFSLFSSKGYDSTSTQDIINLSGLSRG
                     AMYHHFKTKEDILRSVTKELYSQMNNFLEHLVADDTLTANEKIIELVVHSANDYTRRK
                     MVHCSWLEKIPFALIEEVRNLNNVVAPNIAKIIKQGVENKEFSCEYPEELAEMLVFSI
                     DILLDPVLFKREYSEVCNRLDFLLFMLKKMDIPLIDEYGIQKFKDLFKQ"
     gene            complement(17209..18864)
                     /gene="ilvD"
                     /locus_tag="KNP36_002799"
     CDS             complement(17209..18864)
                     /gene="ilvD"
                     /locus_tag="KNP36_002799"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020457899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HBF0874658.1"
                     /translation="MRSDIKKGIEGAPKRALMYGMGLTKEEIERPLIGIVNAQNEVIP
                     GHLHLDEIAEAAKNGVRMSGGLPLEFPAIGVCDGIAMGHVGMNYSLASRELIADSIEA
                     MAMAHGFDALVLIPNCDKIVPGMLMAAARLNIPSIVVSGGPMLPGKKNGKVYDFNSAM
                     EGVGACKDGTVSEEELEELAMNSCPGCGSCSGLFTANSMNCLTEALGMGIPYNGTAAS
                     HSGERKRIAKYAGMYVMELLKNDIKPRDILTIDAFKNAIAVDMAMAGSTNTVLHLPAI
                     AYESGIELNLDFFDEISEKTPCLTKLSPSGKHHIEDLHMAGGIPAIMNELSKINGINL
                     DCKTVTGKTIGENIRNCEIENEEVIHTLKNPYSNQGGLAILKGNLALNGAVVKKSAVA
                     EEMLVHEGPARVFNSEEEAVNAIFGKKINKGDVIVIRYEGPKGGPGMKEMLSPTSAVA
                     GMGLDKHVALLTDGRFSGATRGASIGHISPEAMEGGLIGLVEEGDIISINIPDKKLEL
                     KVDEVEIENRKLKFKPLEPKIKHGYLSRYAKLVTSANTGAVLK"
     gene            complement(19188..19487)
                     /locus_tag="KNP36_002800"
     CDS             complement(19188..19487)
                     /locus_tag="KNP36_002800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874659.1"
                     /translation="MKWIKWYSITCICIFIVVAFYMFIFPNKIETIDTSSAYSFVEKK
                     VPNSAVYQGYKKNPVDGTTTIYYSYDNSTHIVRLSHPEDYSRKINWDKVSNIRFD"
BASE COUNT         6664 a         3244 c         2110 g         7524 t
ORIGIN      
        1 tctatagtgt tacttatatt ttatatatat ggctattttt caacatttta caatatataa
       61 catttatttt tttaactttt gtcagtaaaa tgtcagcaaa acactttatc cacaattttt
      121 atataagttt tccacaactt atcaccaata ttatccacat aaaaaaggta gcacttatat
      181 tattagctac cttttattta ttaatcttta tatttccagc tttttatcca acttcctatt
      241 tctattattt tttcttcagt tatttcttct ccatcatgta attttgaaat taattctgat
      301 aaaggattgt tatgtaaacc tctaaaaact ctttttccct ctattttgag atattctctc
      361 tcttttatta atactgtata gtgtacatgc ctcccaattc tctatgatat taaaaaacct
      421 tttttggtta atctagctaa aagtataatt gtagttgtat gcttccaacc atatgttttt
      481 tctatttcat ctgcaacatc ttttgatatt acagttttat aaccagtatg ccatatgcat
      541 ttcataattt ttaattctgt atctggtaat tttttattta gcataatata ttccttcttt
      601 caatttatgt cacttcttca aatttatcta gcttaaatta taataggagc tttttagaac
      661 aaaaactata tttaattttt accaggtact ctacgtgttt agtctgtttt taagtgtaaa
      721 ataatgttca tatctataaa tttatttaac tttcaaacaa tcctgttgaa taataactaa
      781 ttctattgta ttattttagt tgtagaataa aactaaatcg gcaaaactag agaaatttag
      841 tgacgcaaag ctatagggac taagacttat ataaatatct tatgagttat gtcagccagt
      901 tgccaaagag atagtgttct ttttgttttt atgaaagttt tttaggggga taataattta
      961 tatgtttgga aataaaatgg ataaatgtac acatgtattg actgcttata ttagcagttc
     1021 gtatgattat tgtaattttt tagatacaca gttagatgat tttatattag agtacggaga
     1081 aaatgtagta gagtcttgtt tacaccaagt aatggtattg gtaagtaagt ataattagat
     1141 agacattgat ttctagaaaa ccctttttag ttttatctac atttatatta atatatagca
     1201 atgtaaaacg tttaaatata tttttaatat taagaataat taaaatgtta actaaaaaat
     1261 ataattaagt agacatttct attaatctat gatacaatag tatttgtggt aatacacaat
     1321 taaatcaagt atatcttgat ataggttaat aggagtattt ttaatgaata atggaatagt
     1381 gaaatggttt aataatgaaa aaggattcgg ttttatatca atggaaggta gagatgatgt
     1441 gtttgctcat ttctcagcta tacaaacttc aggatttaaa tcattagaag aaggtcaaca
     1501 agtaagcttt gatatagtta aaggtgctag aggtcctcaa gcagaaaata taactatatt
     1561 ataatatata gatttttcgg gaaagactct ttttagagtc tttttttatt gttaatatat
     1621 gtaagataat cattggtgaa gtaaataagg tatattgagt aatgttcttg atagtttata
     1681 tgctaatgaa tttcaaaaaa ataagcactc ctataaaaag agtgctctta atgtaaatat
     1741 aaaccttcat tggtccagcc taataccccg tattctccaa gttctaacta ttttttatat
     1801 acattatcac tttcatccat atctaacaca attatttctt ctttagaatc aatttgtaaa
     1861 atatgaggac tgtgtgttgt gacaattatt tgtgttttta ggagaattgc ttttaatgta
     1921 ataaaaattt tacataccac atagttgata taaaactata ataattacat aagattgtaa
     1981 taataagact tatctttaca taccacatag ttgatataaa acaatgaaat taacatacaa
     2041 gagactaaga caattaaaat ctttacatac cacatagttg atataaaacc ccaaaataaa
     2101 cttagcatct ccaatgttta cacatataca atgctcttaa aattgcagtg aacgcgcaat
     2161 agtgcaattg ataatactta ttatatattc tcaatgcctt atatttcaac tgctaaacct
     2221 caatttgtca caaatatcgc tcactgcaaa atttctatat ttttattata tcataacata
     2281 taattaatat tttcaattaa tttttacatt taattatgtt taaattctat aataatgcaa
     2341 ctttaatgtt tctttctgga actaatataa aaactatttc agaaagatta ggtcatgcag
     2401 atataaaaat aactatgaat agctactctc agtttttaga agagatggac agagaagcat
     2461 ttgaaaattt gagcaaaata ctatttatta tattttaaag aagatgactt attcaatatt
     2521 tgatgctaga atataattaa taaaaattta attataggtg attgtattat gaatattatt
     2581 aaaagcataa ctttactctt aacattatta attgtgatat taatgacagg ctgttcccca
     2641 agagaaagtg ctagtgaagt tgcaaaaaaa tatattgata agatgaactc tggtgactat
     2701 gaaacagcat atagtttatt aagtaaagat agtaaaaaaa aaattagtat agaaaatctt
     2761 gaagaatttc aaaatatttt agttagtaca aaaagaataa ttagttataa aataggtaaa
     2821 gaaaaaatca taaaaaaata taaacatgat ggaaaagaat ataaaaatgt tgttaaatta
     2881 gaagaaactt ttaatataaa aaaccttctt tataaaaaag atgattctct aaaagtaaat
     2941 agatattttg tagttgaaaa taacaaatac aagctattat tgtatgaaag tttcaaaaaa
     3001 gaatttggta ttaatagtat ggaccttgct caacttaagc ttaatgattt tggactaaaa
     3061 tactttaaag aagttgacct tatactaaaa aaagctattg ctattaatcc tactgattca
     3121 aagctttatt atgcccaagc atgtaattat atgaattttg atggatttcc tggttattca
     3181 gatacaacat ataatgcttt agattcaatt aataaatctt taaagtattt agataaaaat
     3241 gattctgact acaaaaaaaa tgcaagtaat atatataact taaaaggagt tattcttatg
     3301 tttcacaaaa gatttgatga agcacaacaa tatttaaata aagccttata ctttaacaaa
     3361 gataatgaag acccaaaata taatctaaat acaataaaaa aacatctaaa ctagatattt
     3421 aatttttgaa tttataaaat atttttttat gtataattca gcactgaatc ataatttcta
     3481 ctaaactaat tacaagttta aattataaag acttatttct atataaatat tactctataa
     3541 caataagttt cttatttaaa ttttaaaata ttatctaaaa atcataaaaa agaaggtata
     3601 aagagctacc ctcaagctca atatacctta taaatatcta aacttcattt tttactaatt
     3661 tttctatatc tttgataata tgttctttag atttttttcc agctatggca tcaaaaattg
     3721 caacagcctt tttctctcca aacttttctg ctacatcatt aaagtctaaa aatctaacac
     3781 tttcttttgg tttaccaaac atataacacc tctcatacat ttttatatat ttattataac
     3841 ttctatagac ttatttttca ccaataaacg ttagacaaat tagtcccttt atttttttaa
     3901 actagcttta ccttcaaaat tcttaacaaa aacagtttat tctactctat aaataaaaat
     3961 agacaattta atttgtagga aactgataat agaatacagt aaataaaact ttgtttaatc
     4021 tatctgaaaa agttatctat taaaactgct atgaatttat aaagaatatt ctagttcata
     4081 aaaatacaaa tatgtaaata taatcacctt aatattcaat ttatttaaaa taaaaaatgt
     4141 ataaaagatt taataatgac aatatactat tctcaataca atctatgatg taaataattt
     4201 aaaactacta tattatttaa aaatttatat ttatatatgc aattctaaaa acttaataag
     4261 aagtgaactt agaaaataaa gcttaatttc aaagacttaa atagactatt attattagtc
     4321 taaataaact acgtctatca aaattatata ttaaattctt ctaaaatttt tattgcaaat
     4381 cttgcgtttg gatatgtaat agacccgcca ccaattacac ctatttttat agcttctata
     4441 atttcatctt tacttgctcc agaattaata caaccctcaa tatgataaca aatacactca
     4501 tcacatcggc ttaaaattga aatagctagt cccattaatt ccttattttt tttgcttata
     4561 gccccttctg aataagtctt atcatcaaga cttccaaata ctctaaaaaa ctcatctgtt
     4621 tcgcttaatt ttttattgta aaatccccta tattctttca tttctctagt attcatcttc
     4681 tacctcctat gtttttctta taagaatatc acaccgtact tatattttca atattaaata
     4741 caaattttca ttttatgttc attagcctaa tttatattat tttttgaaat ctcaataagt
     4801 tatcatataa gtaagatttt ttcagaacta aaatagaaat cttagtaatt tctttattat
     4861 ctatctcagt tctgaaatat attattctta tccaaacatt attatagtga ttaattatat
     4921 tagttatttt tacctgaaat tttatacatc aaataagaat atataaatgg tagtattaca
     4981 attacaaaga ttacaaagat attataaaaa ggaatattaa taaatgcatt aataattaat
     5041 aatattccac caataagcca aatccatcca gctaaatggt gtgtcttatt ccaattatct
     5101 tcatcattaa gagtccatgg taaaattatt cctactgagt aatttcgttt acatttagga
     5161 agatagtttc caaataaaat aactattatt cctaaaatta atcctgtata aaaattagac
     5221 tccaaactaa ctcctgttga atataaaacc atcattattt gtataattac tgaaagtata
     5281 gcaactcccc attttgataa attttgtata acatttgaaa aattagcttt cttaggctca
     5341 ttctcaagtc taaaccatgt atacaaatgg atacatagca ttaacaatgg tacaccaaaa
     5401 gctgctataa cctttggagc ataattatct ggatttccat aattatcaaa atgaattgca
     5461 acttcatttg gtaatctatt ataaaaatat attgatacaa taaatggtat aaaacatatt
     5521 aaagtagata aaataaattg tttatttatc gcttttttca ttatcttttt ctcccttctc
     5581 cataaattgt gaaaaccaaa gcatgacctc ttcgaaaact gaaatattta tttcgtagaa
     5641 aataaagttc ttatactttg tttcaaatat gagtcctgcc ttttttagtt gagatagatg
     5701 ataagaaatt gtagcattcg tcatattaaa tttttcacta atttctcctg ctgacatttt
     5761 attctccctc aacataacca atatttctct tcttataggg tctgaaagag ctttgaatgt
     5821 ttctggaaac cccaacacca tcacctcgct atttagaatt tcatctaaat agaatataac
     5881 ataacatcca ttttatttca atagctattt agaaattttt ctaaatagtt atttctaaat
     5941 atttattgaa aatttttata ttaagattct caatttactt aagtcgcttt tatttaatct
     6001 tactttatct aattttttta acttaacaaa agtgtattgc accataattg ttaaagcaaa
     6061 aacctaatga ttgaggtact tatatatata acaatacttt taattttaaa ttaaaagtag
     6121 ctaaacccaa tttaaaaagt agttaagtcc tatttaaata gaaaagaatg aaacgagaaa
     6181 tatactgtat aaaagtacat aaaaacatct actaattaga tacaactata acagaatata
     6241 tttattatta taataacaaa agaataaaaa aaattaattt agcataacct tgttaaatat
     6301 agatttgaat atgaatttaa agttatgtaa aattaaaaat acaggaatga aaattccatt
     6361 cctgtataaa atctaacttt tgagtctcag tacaatctta ttttgagaca atcttttttg
     6421 ttttatattt tcttatattt aaaatataac gcatatctta tgcaacatat tcatattttt
     6481 ctttatattc tttcatcgca tcattccaag cgtcttgtac tgttacacct cttttattag
     6541 caattttttg tgccagttca attatcttca tagctcttct tgatatgttc ataaacattc
     6601 ctcctacaaa ttaccatata tttcatatat ataaatcaag gttatatttt tatgatatat
     6661 aatccttcta ttgtaagatt acagtttata tgtgtattat atatgaacta tattagaaga
     6721 taattagaat ttttataaag ctatatgatt agattaaata taaaagcttt acaattactt
     6781 ataaatttaa aaagtctata agctaaacta atgtttgata taccaatttt acgaccataa
     6841 ataatgccat tactaaaaat attggtttta tcatctttga acctttcttt atagcaactt
     6901 tagcacctac ataagctccc attatcatca ctaatgcaaa cactatagca attttataat
     6961 ctacttgacc atttatcatg aataataaca atgaagttat attacttgtt aagtttaata
     7021 tttttgtatt tgcagaagca tgtaaaaaat catatccata tatttttata aatccaaaag
     7081 tcaaaaaagt tcctgtacct ggaccaaaaa aaccatcata aaaacccatt ataagagcca
     7141 taagcatccc taatcttaaa tttttcttat taacagcttc aaaattatct tcttgaccta
     7201 aatttttaga aataaaggtg taaatagcca ctattaaaat cataaccaca accaaaacat
     7261 ttaatatctc ttcacttatt gataatacac atctcacacc tagaacacta ccaataatag
     7321 taaatggtac taattttttt aaaaggttgt tattaatttt tccagacttt gcatatctat
     7381 aggcactact tatacatcct gctgatgctg caaatttatt tgtaccaatg gcaagatgta
     7441 ctggcactcc aattgccata agaacaggca tgcttataag tcctcctcct cctgctatag
     7501 aatctacaaa agcagctaaa aaccccccta tacataaaaa aataactgaa aacataaaat
     7561 tcctccatca ttctctttca atttttctta caatatatat tatataatct tatttaatac
     7621 ttattatcca gcatattctt tctatattca tttggagtta tactattaaa cttcttaaat
     7681 atttgtgaaa aataactact gttattaaaa cctactttct tacaaatatc actaatactc
     7741 atgcttctat ctaacagata ttttttagat tcttctatcc taagaagatt tatatactca
     7801 gttattgaaa ctttatttct ttcattaaaa atagaactca aataatttgg acttataaaa
     7861 aaaacatctg atatactatt caaatttata ttttctttat aatatttttt tatatattcg
     7921 tttatatttt caattagatt tcctttatct tttctccaaa atgctctatt cttatcaata
     7981 cactctttgg aaaattcaaa taatacattc cataaatctt catcactgtt tacaagtgat
     8041 atttttttat tatatttatt tcttaaataa gatataagtt ttaaatcctc taaatctcta
     8101 agcactgttc tagacaatac aaatatcatt tcctgaatag tatctctaac atcattatat
     8161 cttaatttgt ttgtatctat tagattataa acaccttcta aattcatatt tttaatttct
     8221 ttttcaatat aaagttctaa ttcaaaggga tattcttttg aagaattatt gaacatatct
     8281 atcggattaa taatatactc ttcttctaat aatctactat ttgctttttt aagtgcctct
     8341 tcaagtctta tattttcttt tctactcttc aatatctcct catcttttat actaagttga
     8401 ttttcaaaaa aattcctctt agctatttcc tgaataaatt cagacatcat taataaattt
     8461 tcttttaata catataatct acttttagga tttaatggaa attcattgta aattttgttt
     8521 atgtatttta tatcaatacc agaactactt gataattcag ataaattttt atctatatca
     8581 atagacttat atactataaa attaccacat tctatatatc caactatatt ttcttctaat
     8641 actataggta tctctaaact ggaaacacca tactcacaat ggtacacttt ttcaaagtta
     8701 tcattattta tgcttttaac aagtttttta gtacactgtt ttatattttt acaaatatcg
     8761 caaaatttat tttctttctt agtctcaaat atttctttat actttaagtc atatacagat
     8821 attctaagct tcaatatatt agatatttga tttgcaagat tttcaattat gtttacatta
     8881 actaactcct gtatattgtt ttcagaaaat actataggta tttgtctcaa actcgaaaat
     8941 ttatgaggaa cataagtaat taatattact aaatcaattt taccagtgtt tataatttca
     9001 tgttctgaat atggtgggca ataaactata gatgtttcct ttatattgac ctttttacca
     9061 tcaattattt gtattccttc tccctgaatc acatataaaa gctgttcttc acttaaatga
     9121 aaatgctttt cttggtagtt tcccggaaaa aatcttacaa ttccagcact aagtctattg
     9181 aattgtgttt ttgatggttc gtgtatccac ataacctctc cccaatcaaa tttttgtact
     9241 tcattatttg actcactaaa atactccata agctcacctc ttagtttttg tctaaatatt
     9301 ttttcttccc ttcttatatt aaaataatat catcatcatt aactttcatt actataaaat
     9361 catcatactc ttttaatact cctgtaattt tagttgcact tagtttacta caattcagtt
     9421 ttttaatata ttgataaatt ctataattac ttttttattt tgtaaaatca gtgttttccc
     9481 aaaataatta tatctataaa tgaaagtatt tttactgctt acatcaatat atgttatcat
     9541 aattttcctt tttattgcat atataaataa ctgtatataa cattgtccaa tactatatag
     9601 aaatacatct aagaaagaat attattaaat tgttccaatt agtattattt ttcttataga
     9661 aataaaaaaa ctgttggagt cttttagaaa aattattttt tacatacctt ttttgcttag
     9721 atagtctatc ttcacagcta ttttgtatat acactcttct agttcatgat tttattttaa
     9781 tatcttgctt atattgctga aataattgaa ttcttttatc tatcatattg tctcttatat
     9841 cacaaacata ttgtttctta tatcacaaaa atgaaagcat tcttatatct tcaatatata
     9901 aacctgcttt ttttaatctt gtaataaata taggatactc tatattctct tcctagaaat
     9961 aactaatacc acttattttt ctattatata gaaagtaata aatctttttc ttaataaaat
    10021 tcaatagtaa gtggaataaa attttatatg aataagaaca ttataaaaat actttataca
    10081 atagtcaata aaagatatta gcttcaaatt atgttaaagt tgtattattt aaagtgaaaa
    10141 aacaaataaa aaagaaataa tagtataagt agaaaaatat acttaaaaca aggcgaagcc
    10201 tctcttgtat ctaaatcaag tagagaatta aatctaaaaa agaaaataaa tataaaagat
    10261 gactcctgta cattacaaga atcatcttat ggtttcataa tcactccatg gtttttaact
    10321 gtctgatata aaggtctcag ttcactcata gcatgaccac cttttccgat tgctgacccc
    10381 gtcacttatg gacaaaatgt ccataagtga tagtcctctc ttaaaaccct ctaaatagat
    10441 atatctcaag caccgcattg aaaccagttg ctggaaacaa actgaagcgt tctggaatag
    10501 taaaagaaat tgccaccata tccacgttac tgtcctagtt gttactttgc taacttcgga
    10561 gcgatttcct ctaacaatac gcagtcaaat tctgcctttt tgctaagaaa tggcagatgg
    10621 tctgcatctg gtataaaaaa aatctgtttg tctggcgcca ctatttcatc aaaaaatttc
    10681 ttcgctggaa gataggggct attatagtca ttttctccca tgatgtagta tacagggacc
    10741 tgatagtcaa ctccataatt tcttatgtca gcttcttcca ctaaaaaccg caatacatca
    10801 ccttgattgt caatcgcatt tggattgaaa atggccgtat tttttaactc tctcaatgaa
    10861 taatacgggg ttgccagtat actgattata ttgcccaaat ccatatttat agaaagccca
    10921 tacttgcttt ggtatgttct tactgtcata agagctgcca aatagcttgg accatatttt
    10981 gctggcggat atggtgcaat agcttccagc gccttgatat ctttttgctt ccctgcagct
    11041 ttcaccattt caagtgtctt ttcatagccc acgcgctcat tgtccaccat attaacggtc
    11101 tgcgcaatcc caatgtacgc gctgtaatcc tccggatagg tttgcacagc catagttccc
    11161 agaactgttc cccagctatg acctataagg ataattttct ccttgttgaa ctcttgcttc
    11221 aaatatgctg tcacctcatg gacgtcttgc agaacacgct ccgcgctcat ggtctgcaaa
    11281 actgctgccg gatcgttcgc aaagtatgtt ttgcctacgt ttcgctgatc ccagttcacc
    11341 acagtaaaat cattttccca ctcatactgg tacagatgta aaaatggcat cattgaatta
    11401 ccaggacccc catgaaccca aaggatgatg gggttgtctg cgttttgtcc ccggatatat
    11461 aacgcctgct gtatgccgcc gatctccacc atttccatgc ggtcgattcc aggagcttct
    11521 attttatggc ttgtacgtat aatcgtgggg gctatcagac gcaaaccggc aaacgccaga
    11581 acaaaaacag caactagtat gcaaagtgtg attaatatca ttttaagtac cttctttcat
    11641 gaattttttt agccatagat atctcctcta acattaaaaa aaatatgttg ctattttagt
    11701 tttgttactc tacctgtccc attggtttcc tttcataaaa aatattaatt gattctataa
    11761 tctcatcttc caggatatca actcctattt gtctcataag aaactgtaag aattgaaacc
    11821 gtttacgaag tgtaggaaag tccccctgaa atacatctgt atcacaccaa aagttaaaga
    11881 gcagcaaaat tacctctgcg cattcatctg ggaactctgt gatgatgctt ctatcctcta
    11941 tgccttctcg taaaacattt gctaatattg gtgctagttt tttcaaatta tcctgtgtaa
    12001 atgccagtat gatatgcgga ctttctatcg cgcttgtaat catgttacta gattctttta
    12061 tcacctcatc cgttaaatgc cgcctaacta aacttctaag cttctctttt gctgtaagtc
    12121 catgcatttc accgagccat tgatttactg tctctattat ctgttcaaag cgcctttcca
    12181 tgaccacatt aaaaatatct tcttttgaac tgaagtgatg aaaaattccg ccctttgaca
    12241 ttcctgaagc atcaacaata ttttgcatac ttgttttgtc atatcctttt tcagcaaaca
    12301 actttgcaga aatggtaatg atattttcaa tagcttgctt tggattgttc tttctagtca
    12361 ttatataact ccttcttatt aaaaaccgac tgttggtttt tattatataa gctattcctg
    12421 cttctgtcaa gtaacattgt gtttatggca aaacaataag gtttggtggt tagacaggta
    12481 ttaattagac taatgcgact ttcccctaga tggaaccctt ggtaaatttg caatctttac
    12541 cggctttgat tatatctgta agcaaggcag gtatggccac acctgccctg tttgcccctc
    12601 ggatattcat tcctatccct cctctcctta gccattacac caaaacgccg ctcattgtct
    12661 ccaatggcgg cgttttaaag atatgatttc tcatgctgct gaaatatgca aaaaatataa
    12721 gatgcccttt attatttttc ctacaataga aaagaaaagt attgaagaat gggttaatat
    12781 tggagcaaat atgctttgtt tggcacaaga tactaccttt atcacttatg ttatcaatca
    12841 attattatct ttttataatg agattgtacc aattcaaaaa caacattaaa ttataaatct
    12901 aattttatat taaaagagac taatatttta tctatctcta ttaaggatat tttcttatgt
    12961 atcataatat tagtctctct tattattata tactgctatc atcattagtt gctatttata
    13021 ctatttttat aatatacaaa tttattcagc taacgttttg cctaattcta tacactcatc
    13081 ttttgcttct tcatttgggt cttccattgc tgtaattcct tctccaccaa taattgtagc
    13141 accagcattt tgcatacgtt cttcccagtc tctcatccat tcacaatttc cccatccata
    13201 tgaaccaaat aatccaatct gtttacctga taccatagat tctaattctg aaacaaatgg
    13261 ctccatatac ccctcttcta gttgctctgc tcccatagat gggcaaccta atgcaaattt
    13321 atcttcttct tttaaatcac ttggtttcag taagctcaca tctaaaactt ctggtgtctt
    13381 accttttaac ttcacacctt cagccacaaa atttgccatt ttttcagtat ttcctgttcc
    13441 actccaataa acaatatata ttttactcat ttttacctcc tgtagtattt tttaattaat
    13501 caatagttag ttatagctaa ctaacatcta aaaaacaaaa gatttcttta tctgaaatct
    13561 ctttattttt ctaaatatag aatatcatgg ttgattttga aattcaatac ttattgataa
    13621 tatttatcat ttatatttta tattcatttt ataatatcaa aacactgtat cgtatttcta
    13681 atctttcata gaaaaatttc taacttatag tacttttgca tctcttataa atcttttata
    13741 tgtataagta catagaaaaa cacacctttt ccagatgtgc tatctataat atcgtatatt
    13801 tatttttcaa ttctaactag ctaatatgtt tataaatttt atcacttaat acctttatac
    13861 attgatgtaa aatcttacac ctaagtaatt tttattattt gtctcgactc tatataatat
    13921 agctatttta tcatcaaatc aaaaattatc ttttgctatt attcttgtat ttataaagat
    13981 ttaaatataa gtatccattt ccttgttccg ttctaggtat tccaagcgct ctcgtacatt
    14041 ttattaattg tgcatacagt tcagcttcat ctaaatctct ttcaaactcc tctcttgccc
    14101 attctttaat tagtgctaat gagcctgata cgtatggtgc actcatactg gtaccactca
    14161 taatagcaag tttattatcc atataagtcg atataatatt tcttcctgga gctaccaaat
    14221 ctattgtagt atttgaatta ctaaactttt caaccaaata gttctcattt attgcaccta
    14281 cttctattac ctcagcataa ctggctggat aactatactc acttgtacta gaatcaccat
    14341 ctccattatt acctgctgca cacactacag aaatattatt ttttactgct tgcatgacag
    14401 cattttttaa attcttatca tctttgtttc ccccaagaga catagatata atatcaacct
    14461 tgttatttac agcaaagtta atagcattaa ttatactttg atatgttcca gtaccatctt
    14521 tatttaatgc ttttgctatt aataatttac aatctggagc tactcccata acttcattat
    14581 tataattaga tgcagctata atacccgcca catgagttcc atgaccatta aaatcctcat
    14641 atatattttt atttccatta ctgtcatcac taaaatttgc accaccaatt atttttcctt
    14701 ttaaaagagg atgagatata tcacaacctg tatctattat accaactaca atatttttac
    14761 cagtataacc ttcatcccac attcccctag cattcatttg ttttattcca tatgggaatt
    14821 tattttttgc acctcttaga ttttcattta tttcatatgg aattagtttc attcttttat
    14881 tcatcatata tcctcctaaa aattttattg cttataaaaa tcatgaattt tattttataa
    14941 taggtttata aatcaaatta aaacctatat ctacttattt atatttatga tatatttttt
    15001 atttttagga gtcatatttt attgtatata aaataatatt tagataacta tattaaaaaa
    15061 tacatgtttg cttatataca aaacttacta aaatgtcttt aatatttttg tatacaaaca
    15121 ttatattttt tatataaaaa gctcataaaa attttgatta tattttcata agttaacaaa
    15181 tgtgggtata atatgaattt acaaaattcc tctgtttgta taagtgcttt accaatacaa
    15241 caatatataa tcacattgaa gctatatttg tatttatagt agataatgta tcaaaaattg
    15301 gttatgaata gtaaaaatac cagttaagca tattttcatg tttctatttt taacattaaa
    15361 tttccaatct tcatatgtat atttttaaca aaggtgttta cttatttaaa aactctaaaa
    15421 ctctttcatt aaaatcctgt gcttcttcat atgtagcgtg tcccaatccc tcatagataa
    15481 atatttcgct ttttttaatt ttttctacta aatgaaaaga agcattattt ccaacaattt
    15541 tatcattagc acctcctata attaaggttg gacatgttat tttatttaat tcggaaaagg
    15601 cattatgttc tatgcaagag gtcgcttgaa taataaatcg tttaaaatcc tttggtttac
    15661 ctacttttcc taaaaaagga ataaataatt ggtatttttt taaatatctt tcagaatagg
    15721 atttctttgc tgtgtcaatc attaaatcat tgtaattctg cttcttcgcc atatcaatcc
    15781 aactacaaat aacattttgg atagtatcat tttgctttga agaagtaact gccaacacaa
    15841 gtttctcaac taactcagga taatcaattg ccagatattg agctatcatt ccaccttgag
    15901 aaacacccat tacttctgct ttcataattc caagtttttt cattatatct gcttggtctt
    15961 tagccatatc ccttgtggaa tatttttctg taatttgatt ttttctacta aatacataaa
    16021 ccttataatc ttttgtaaat tgcttatatc taaaagcaaa agcaatcgcc tgtatttttc
    16081 catgtaaagg aaataaacca tctcctaatc ctggtaaaat aattagtgtc ttcttaccac
    16141 taccaaattc aatataattc actgtattac ttcctatcat catttgacaa ctttttgcat
    16201 tataaaacat agtctattcc tcacttttcc tattatcatt gtttaaataa atctttaaat
    16261 ttttgaatac catactcatc aattagagga atatccattt tttttaacat gaataataaa
    16321 aaatccaacc tattacatac ttcactgtat tcacgtttaa ataatacagg gtcaagtaaa
    16381 atatcaatac taaaaacgag catttcagct aattcctctg gatattcaca agaaaattct
    16441 ttattttcaa caccttgttt aattatctta gcaatattgg gtgcaactac attgttgaga
    16501 ttacgaactt cctctattaa agcgaatggg attttttcta accagctaca atgtaccatt
    16561 tttctacgtg tgtaatcatt cgcactatga acaaccaatt ctattatttt ttcatttgct
    16621 gtaagggtgt catcagcaac aagatgctct aaaaaattat tcatttgtga gtaaagttct
    16681 tttgtgacac ttctcagtat atcttcttta gttttaaagt gatgatacat tgcacctcta
    16741 gatagaccag ataaattgat aatatcttgt gtagatgttg aatcatatcc tttagacgaa
    16801 aatagtgaaa atgctgattg gataattttt tctttactat ttttactttt ttcttctcta
    16861 ttcatatttc cctcctaaaa acagactgtc tgtttgtttt ttattataca ttttaatatt
    16921 tattatgtca agaattaact tactttcaat ttcttcatag ttcagaagga acgaaaagca
    16981 ttccacatca aacttttaaa aagttgtatt acctcaacaa ggtctaaaag atacatctct
    17041 atgctgtact cgtattcctt ataatagaga tgtattgttt tcaaagataa tcaagatttt
    17101 gctatgtttt tcatacaaaa taaaaaggat acctcattag tgctataaca cctaagatat
    17161 ccaattaata ttttcttaac tttttctaat ttacataaat atagtctact attttaaaac
    17221 tgctcctgta tttgctgatg ttaccagttt agcatatcta cttaagtatc catgctttat
    17281 tttcggttct aaaggtttaa attttaattt tctattttct atttcaactt catctacttt
    17341 taactctaat tttttgtctg gtatgtttat agaaattata tctccttctt caactagtcc
    17401 gattaaacca ccttccatag cttctggaga aatatggcct atggatgccc ctctagttgc
    17461 ccctgaaaaa cgaccatcag taagaagtgc tacatgctta tcaagtccca ttcctgcaac
    17521 tgctgatgta ggagatagca tttctttcat tcctggacca ccctttggac cttcatatct
    17581 tataactata acatcacctt tgtttatttt tttaccaaaa atagcattta cagcttcttc
    17641 ttctgaatta aaaactcttg ctggtccttc atgaactaac atttcttctg caactgctga
    17701 cttttttaca acagctccat ttagagcaag atttcctttc aatattgcaa gcccaccttg
    17761 gttactatat ggattcttta atgtatgtat tacttcttca ttttctattt cacaatttct
    17821 tatattttcc cctatagtct tgcctgttac ggttttgcaa tctaaattta ttccatttat
    17881 ctttgaaagt tcgttcatta tagctggtat tcctcctgcc atatgtaaat cttcaatatg
    17941 atgttttcca cttggactta attttgttaa acaaggagtt ttttcactta tttcatcaaa
    18001 aaaatctaag ttaagctcta ttcctgattc ataagctatt gcaggtaagt gaagtactgt
    18061 atttgtagaa ccagccattg ccatatccac agctatagca tttttaaaag catctattgt
    18121 taaaatatct ctaggtttta tgtcgttctt aagtaactcc ataacataca tacctgcata
    18181 ttttgctatc ctttttcttt ctccagaatg tgacgcagca gtaccattat atggtatacc
    18241 catgcctaaa gcttctgtta aacaattcat gctatttgct gtgaaaagac cagaacatga
    18301 accacatcca ggacaagagt tcatggctaa ctcttctaat tcttcttcac ttactgttcc
    18361 atctttacat gctccaacac cctccattgc agagttaaaa tcatatactt ttccattttt
    18421 tttacctgga agcataggcc ctccactcac aacaatactt ggtatattaa gtcttgcagc
    18481 agccattaac atacctggca ctatcttgtc acaattaggt ataagtacca aagcatcaaa
    18541 accatgtgcc atagccatag cttctattga atctgctatt aattctcttg aagccaggga
    18601 ataattcatt ccgacatgcc ccatagctat accatcacat acccctatag caggaaattc
    18661 taatggcaaa ccaccactca ttcttactcc attttttgca gcttctgcta tttcatcaag
    18721 atgcagatga ccaggaatca cctcattttg tgcatttact atacctatta atggtctttc
    18781 aatttcttct ttagtaagac ccattccata cattaacgct ctctttggag ctccttctat
    18841 tccttttttt atatcacttc tcataatatt acctctttct tactttttta aattttcata
    18901 atattattat aatatatttt tctattaatt aattacgaaa attgtaaaaa aatattagca
    18961 tatactaatg aaaatttatt acgatttttt atcaatatct tacacaatcg tattatataa
    19021 tattatcttt tcaatatatt ttataaacta atatatttta caaattgttg agtaatattt
    19081 tatgatataa atcagaagag gcacttctat aatagaaagt gctcaactat gaataagatt
    19141 aataatatat ttgccttaga tatatagact tttataaata ttaaagatta atcaaatctg
    19201 atgtttgaaa ctttatccca attaatcttc cttgaatagt cttctggatg tgataatcta
    19261 actatatgag ttgaattatc atagctgtaa taaattgtag tagtaccatc aactggattc
    19321 tttttgtatc cttgatacac agcactattt ggtactttct tttcaacaaa gctatatgca
    19381 gatgaagtat caatagtttc tattttatta ggaaatataa acatataaaa agctactact
    19441 ataaaaatac atatgcatgt aatactatac catttaatcc atttcataaa attcctccta
    19501 ctttaccaaa atatactatt attatttcca tatatttata at
//
LOCUS       DAEHWM010000080        19340 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.081, whole genome shotgun sequence.
ACCESSION   DAEHWM010000080 DAEHWM010000000
VERSION     DAEHWM010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19340)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19340)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19340
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.081"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            43..1971
                     /locus_tag="KNP36_002801"
     CDS             43..1971
                     /locus_tag="KNP36_002801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0874660.1"
                     /translation="MVWHIEYEIFSAIIVIFLMVYFFRSKFIPTLQNKIYCALLIFSF
                     LFIISNILGSFCLNNIDKIPIFITFLLNQIYLLLLPIPAALVSFYVMAIIYQDIRYMK
                     KRLLFLSIPLIICIILSITNPFTHILFGLSKETGYIRGCGYVATFASFFFYAIYSAFL
                     SFKYRKAMHESKIWAIRGFLIVSIVAIILQAIFLQYLLTGTACACSLLLTYLSMQNRG
                     LIIDDLTGVLNRQSFIQELDLNINTEQSGFIITIALDDFKFMNETFGTKNGDIALKEV
                     GKYLIQIHDVNHVYRIGGDIFSIVVNSQLGIEPDDIIRKIEERFKKPWLVEEISFNLA
                     TSIAVVYYPENAETTEDVIVAIDFSIHEAKRSESRRVVYADASISEKIKKKHVIKNCL
                     KEALKNDGFEVYYQPIFSNSRGRFTSAEALLRLEHKELGFIPPDEFIPIAEQTGLINS
                     IGLVVFEKVCRFIASDEFEDLKLDNIAVNLSVVQCMQKNLADDLLYLMNKYNVSPTKF
                     KLEITETVAMGSFNIIKETMERLIDLGVKFALDDFGIAYSGVTNMLSLPFSVIKLDKS
                     LIWSMNEDSRHKLTVETIIALINKLNMKAVAEGVETIKCAEDLIAMECEYLQGYYFSK
                     PVPEDVFKNLLKENTFTS"
     gene            2148..2558
                     /locus_tag="KNP36_002802"
     CDS             2148..2558
                     /locus_tag="KNP36_002802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HBF0874661.1"
                     /translation="MNKKKILVPIDGTERSMHSLEFIKGIFKKDEVEVEIMNVKELVF
                     IDGISLAEEIKNSENLGRRILDKAAEIMGEYDVKVHFTFGYPGDEIIRKAKEDNVDFI
                     VMTKSTKKGLTRMIGSVTASVVKQAKCIVMIVPE"
     gene            2580..2882
                     /locus_tag="KNP36_002803"
     CDS             2580..2882
                     /locus_tag="KNP36_002803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIBC"
                     /protein_id="HBF0874662.1"
                     /translation="MNKKIVAVCESERSLNSLKTAANDLGFDLVYEIQENDNIKNELS
                     IYDIEDASIVLFVTSDSIESIEKIDRFIDREFYEVDPKYIIEDAKSIVSEILIDLN"
     gene            complement(3099..3791)
                     /locus_tag="KNP36_002804"
     CDS             complement(3099..3791)
                     /locus_tag="KNP36_002804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FadR family transcriptional regulator"
                     /protein_id="HBF0874663.1"
                     /translation="MKSLNATEKIIDYIKLNILNGTFKINSKLPSERKIADLFNISRI
                     PVRNAINILCKEGILRAVPYSSPIVEGFKKVDLFDDGEIYKNHNIQEFYVESLRARQL
                     IESEATKLAILNATSKELQKIKYTYLKSIEELDKVSHGLIEECYDADLQFHKEIILAS
                     HNPIFIKYYELIPKTVSSNQYFGFKYRNSLKDMISHHNKIMIAFDSKDSYLGYTSMYN
                     HLEDVIQLFQHD"
     gene            complement(3817..5004)
                     /locus_tag="KNP36_002805"
     CDS             complement(3817..5004)
                     /locus_tag="KNP36_002805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0874664.1"
                     /translation="MKKISNQKLLLLSIVTFFWFSQYVYIPFQNPYLSACNVSTNMIG
                     IIIGAYGISQCLLRLPVGVFADSINKHKIFILSGIFFAGLASLIRVFSPGGNGFLIAN
                     ILSGISSSTWISYMVHYTNFFSTEHQQKATSTIILVNNLGMLIGFVMSTLFYEKLGMT
                     ALCIMSVLSSVIGTILALNIKNHNSKKIPEKISIKKYLSICKDKRLVFFSFMALIQQG
                     IQMSTTMSFTTQILKNLGSSSTLIGLSSIFYMVCAVASSGFASTKFCTKYGPKFWIPL
                     VFILVSAYCFLVPTIKNINIIFVLQVLPGISTGILLSYLTSESMKNVPKHQKSTAMGF
                     FQAIYAIGMSVFPMIVGKISEYTSIQYGYFILAIIAILASILSYTYYKKVDLTLNYDI
                     IQS"
     gene            5340..7217
                     /locus_tag="KNP36_002806"
     CDS             5340..7217
                     /locus_tag="KNP36_002806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0874665.1"
                     /translation="MDYKNIAQEILLNVGGKENVNEVTHCMTRLRFKVKSASKVNKDK
                     LSKTEGVITVVESMGQIQVVIGNKVKKVYDEVIKIVPQSNNIGKKNESQEKQGIINSI
                     LSAVAGIFTPTIPAIAGVGMIKGILSVLAMYYMNKNGVDIKETQSYIILNAMADSIFY
                     FMPIILGYTAAKVFNANKIISMVLGATLCYPTFTALMAGEESVRFLGLAVTKATYTSS
                     VIPIIIAIWALSYVEKVLEKYIPEVIKIIMVPTLSLVVMLPATLFLFGPIGIYIGNVI
                     NFSYKYIYELSPALCGAFVGGLWCVLVIFGAHRALLPIGISDVAQTGRQNLLAFAGAA
                     NFSQAGAALGVFFKTKNQGLKTISMSATITALFGITEPAIYGANLRLKKPMVCAVICG
                     AFGGAIMGMGGAYGNAFANQGVLTIPVYAEAGALGFLSYLGGCAIAFFGSAISTYLVG
                     FEDLEESSNKENSSIKVETKDGVIDITSPVEGECIELSEVKDDVFASKAMGEGIAVLP
                     TKGVITAPTDCEVASLFPTLHAIGLKLDNGAEMLIHVGINTVELNGKYFTKHVNQGDL
                     VKKGDKLISFDIDKIKKAGYDVTTPVIVNNTFDFGQVVSCKSSYVSTNDNIISLVLAG
                     N"
     gene            7574..8980
                     /locus_tag="KNP36_002807"
     CDS             7574..8980
                     /locus_tag="KNP36_002807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HBF0874666.1"
                     /translation="MNTGFPKDFLWGASSSAFQVEGAWDKDNKGKTVADYNSFKKSHL
                     QADTKVASDFYHNYEEDIELMKELGMKTYRFSISWARIIPDGEGEINQKGLEFYNKII
                     DKLIECDIEPFVTLYHFDLPFKLVEKYNGWESRETVYAFERFAKICFKHFGDRVKYWQ
                     PHNEQNLIVRVEERINIYDETDSWKIDKMRAQMDYNLCLAHALAVNACHEMIKESKIG
                     AAVSSSVTYPLTSKPEDVYAARMNDNFKVYYMLDMHHYGEYPGYYMKYLEKRNIVPHM
                     EDGDKEILKKAKMDFIAVNYYRTNCAEALPEDSQHPFGLREGTVDFSMYGLFKMSMNP
                     NLEASEYGAAIDPSGLRVALNEYWQRYHLPVIITENGLGAKDILEDGKIHDDYRIDYL
                     RSHINACKLAIEDGVEMIGYCPWSFTDLLSSSQGFNKRYGLVYINRTDHEVLDLKRIK
                     KDSFYWYKEVIENNGIVK"
     gene            9008..9856
                     /locus_tag="KNP36_002808"
     CDS             9008..9856
                     /locus_tag="KNP36_002808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0874667.1"
                     /translation="MYITKVLNNSLLLAKDDNDEEIILMGKGIGHNYKAGSELNKKDI
                     EKIFVLHDENIKKSIIQLATEIDAEYFGIAQMIIAYGIEKYNLKLMNHIYLALTDHIA
                     FAVRRFKEGIMIENHYLFEIKEFNPKEYDIGKYAITVFKEVLGLDLPEEEIGNIAGHF
                     INAQQDNPYSDRNKRSAKIVNAILQIVHYHFSIVYNKESFYYRRFVMHLKAFSQRFLA
                     NEPSREKIDFIYEQVQKNCKEEYECVKKVGAYMYKEYSRELPRQEELYLMIHIHKILG
                     ELCENS"
     gene            10517..11209
                     /locus_tag="KNP36_002809"
     CDS             10517..11209
                     /locus_tag="KNP36_002809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003020373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874668.1"
                     /translation="MNKVLIIDDDKDLCILLKKSISIEQIEANYCHSGRDGLVELSKQ
                     DYQLVVLDVMMPGMDGFETMEQIRKYSSIPILMLTSKSDNYSKVHGLRAGADDYLTKP
                     FEITEFTARVLSLIRRYTRFNPKNEEPQQLSFKGLLIDLDQHTVTTNGEPMLLPPKEF
                     GVLLYCARHQGKILTKQQIYEAVWGEPYVYDDSNIMAIISRLRKKIELDPSSPIYLQT
                     IKGIGYQFNTEV"
     gene            11206..12141
                     /locus_tag="KNP36_002810"
     CDS             11206..12141
                     /locus_tag="KNP36_002810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874669.1"
                     /translation="MKMDEQTIILFLLLLSIGLLFLSIFAFSKLGHIYKRLKDIEEIL
                     ADVQIGDENRKILIKPCDVMAPLVYQLNEIVYDYENKLLSLKKSDKASKQLMTSLSHD
                     VRTPLTTLIGYLDAVHSGIVIEQEREEYLEIARRRAYDLKDYIDVLFDWFRLNSDEFT
                     LSIESVEIAELSRNILKDWIPIFHEKKLNFEIDIPENRLMVNLDPDGYSRVVNNLVQN
                     VLAHSKARQIKITMSEDSRMVLLRVEDDGVGIARENLPHIFERLYKCDKGRSEKGSGL
                     GLSIVSQMVERMGGQVSVESEIGKYTVFTVSLPLI"
     gene            12289..13212
                     /locus_tag="KNP36_002811"
     CDS             12289..13212
                     /locus_tag="KNP36_002811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013273760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874670.1"
                     /translation="MNNLIIETKNLTKQYGAQKSVSNLNIHVQKGRIYGLLGRNGAGK
                     TTTMKMLLGLTKPTTGEIKIFGQDIHNNEKKLLPRIGCLIESPGFYPNLTGTENLKIF
                     ARLRGIPKKNAVESALDVVGLPNNDKKLFSQYSLGMKQRLAIALAIMHDPQLLILDEP
                     INGLDPIGIAEVRTFIRDLCTERGKTILISSHILSEIALLADDIGIIDHGILLEEESL
                     AQLEEKNSKYIHFAVSDAAQAARLLETQLNLKNFKVADNYNIMLYDTDVSVAEINRAF
                     ILNNIEVSESHLCEDTLEDYFKKVTGGEGIA"
     gene            13196..13966
                     /locus_tag="KNP36_002812"
     CDS             13196..13966
                     /locus_tag="KNP36_002812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874671.1"
                     /translation="MKELLDIISCEFSKLKRLKFILISILGACLFPIPATILIAKDNL
                     PFEQLFKLVVNFGYFLLLPIVLSIVASQLFFIERDNDVLKNLATVPVQKGKLALAKLA
                     VLLFISLFYSVAGLGATIIGGFIVGIVEGVAVKLGMSIAFGIMFFVTVLPVVVLIVYF
                     NRSYIFSIILSFVYAIFNFSISLNIINFEPNNPILSVLPAPVIMRWWMAFWGDPTGEY
                     TALRQPYLLSTPACVGILCLITIIAVLLICMIYKKQEN"
     gene            13976..14758
                     /locus_tag="KNP36_002813"
     CDS             13976..14758
                     /locus_tag="KNP36_002813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874672.1"
                     /translation="MLDIITTEFQKIKRYNILWIGVVAVLFSALLAVFQVVSSHGSDP
                     LTYESFANGVIWNNFSLSFPFGITLIGGYLINREYTDQTLKNILTVPISLRKLLVGKL
                     IAVGGITVLLSLFSFLCTFILGLLFCNINISVTLVVKSLVQILSVNLYCYVAVLPIIA
                     YFGRKQNAFLTGVGIAFVYGFCGVFVAGRNLTDFYPITAGLGLVGYNNGAGTVYQPLI
                     GAMTLIVILILTTILLVFTPNYDKVMTISKKKGIKHKKYSHK"
     gene            15135..15671
                     /locus_tag="KNP36_002814"
     CDS             15135..15671
                     /locus_tag="KNP36_002814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418513.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rubrerythrin family protein"
                     /protein_id="HBF0874673.1"
                     /translation="MNLKGTKTEKNLMAGFAGESEARNKYTYYASKARKEGYNQIAAI
                     FEETANNEKEHAKLWFKLLHDGMPSTEENLKDAAAGENYEWTDMYAKFAKEAREEGFD
                     KIAYLFEAVGKIEKEHEERYLKLLENLNEGKIFKRDEEVVWQCQNCGHVYVGTEAPEK
                     CPVCDHPKAYFNIKAENY"
     gene            15703..16092
                     /locus_tag="KNP36_002815"
     CDS             15703..16092
                     /locus_tag="KNP36_002815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor"
                     /protein_id="HBF0874674.1"
                     /translation="MKFSKQRELILNEILNNPVHPTADYLYENLKKDNPNLSLGTVYR
                     NLAQLTEHGFIRKVSIPGYPDRFDGRIDNHYHIICEVCGEVYDLESEVLNNLQELISE
                     ETDIKITSYNISFKGICNNCKRCSQVG"
     gene            16129..16515
                     /locus_tag="KNP36_002816"
     CDS             16129..16515
                     /locus_tag="KNP36_002816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="desulfoferrodoxin"
                     /protein_id="HBF0874675.1"
                     /translation="MCSEQKFFICETCGNLVGMIQSGGVPIFCCGKPMKELVPNTTDA
                     AVEKHVPVIEVDGNNVTVKVSSTTHPMTKEHHIAWVYLMTEQGGQRKCLAVDGEPVVK
                     FALNDDDKVISAYAYCNLHGLWKAEL"
     gene            16642..18084
                     /locus_tag="KNP36_002817"
     CDS             16642..18084
                     /locus_tag="KNP36_002817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBF0874676.1"
                     /translation="MSIYKCSVCGYIYDESKNDKTWDELSEDWECPVCTKGRSYFGKI
                     STVYYEEDEKIAEDIVEDESKLNTEKEGDLNYLSTYLRRDDEVEKHMDIIHEMAVTGK
                     SIIEPMRTKLPVISWDDILIMGAQLNPLPLNEHDEVNTTTIIGKKAKKPMIIENPVYI
                     SHMSFGALSKELKIALAKGAAQNKTAMCSGEGGILPEEKEASYKYIFEYVPNKYSVTE
                     ENLKNSDAIEIKIGQGTKPGMGGHLPGEKVTEEIAKVRNKPVGQDVISPSCFEEIQSK
                     EDLKKLVDELREVSEGRPIGVKISAGHIEKDMEFIAYAKPDFVTIDGRGGATGASPKL
                     LKDATSIPTIFALYRARKYIDTHGLDIDLVITGGLRISTDFAKAIAMGADAVAIASSA
                     LMAAACQQYRICGSGKCPVGVATQDEELRKRLHIENSANRVANFLNVSLEELKTFARI
                     SGHKDIHDLSVDDLYTVNSEISNYTNIQHV"
     gene            18381..19196
                     /locus_tag="KNP36_002818"
     CDS             18381..19196
                     /locus_tag="KNP36_002818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0874677.1"
                     /translation="MERLKIQVLVDNNTYIDRYFVGEPAVSYYIEIDGNRILFDSGYS
                     DVFISNAEKLNIDLGNLTHVVFSHGHNDHTRGIQFLENRYDLSTVELISHPNCFIPRK
                     HGEKSIGAPFSAEEIKNIFMYNPKDKPFNLSKNCVFLGEIPSINDFEKRAKIGKCKIG
                     DLWEDDYVLDDSAIVCKTDKGIFIVTGCSHSGICNIVEYAKKVCGDDRVIGILGGFHL
                     FELNNRLDSTIQYLDKEEMRMLYPCHCVSFKVKAKMNEILNINEVGVGLTISI"
BASE COUNT         7030 a         2322 c         3514 g         6474 t
ORIGIN      
        1 attaaaatat ttaaaatcaa acgtcaatag cgagggaagt ttatggtatg gcatatagaa
       61 tatgagattt tttctgcaat tatagttatt tttttaatgg tatacttttt tagaagtaaa
      121 tttataccta ctttacaaaa caaaatatat tgtgcacttt taatattctc atttttattt
      181 ataatttcaa atattttagg ttcattttgt ctaaataata tagacaaaat tccaattttt
      241 attacttttt tattgaatca gatatactta ttgttattgc caataccagc agcacttgta
      301 tcattttatg ttatggctat tatttatcaa gatataaggt atatgaaaaa aagattatta
      361 tttttatcta taccacttat aatttgtata atcttatcta ttacaaatcc ttttacgcat
      421 attctatttg gattgtcaaa agaaacaggt tatatacgag gttgtggata tgttgcaact
      481 tttgcatctt ttttctttta tgcaatatat tcagcatttt tatcttttaa atatagaaaa
      541 gcaatgcatg aatcaaaaat atgggctatt agaggttttc ttatagtttc aattgtggca
      601 attatcttac aggcaatttt tttacagtat cttcttacag gaactgcatg tgcatgtagt
      661 ttacttttga catatctttc tatgcagaat cgaggtctta ttattgatga ccttactggt
      721 gtactcaata gacaatcttt tattcaagag ctagatttga atatcaatac tgaacaatca
      781 ggatttatta ttacaattgc gcttgatgat tttaagttta tgaatgaaac ttttggaaca
      841 aaaaatggag atattgcact aaaagaagtt ggaaaatatt tgattcagat acatgatgta
      901 aaccatgtat atagaatagg gggagatata ttttctattg ttgtcaatag tcaattaggt
      961 atagaaccag atgatattat cagaaagata gaagaaagat ttaaaaagcc ttggctagta
     1021 gaagagataa gttttaattt agcaactagt attgctgttg tttattaccc agaaaatgca
     1081 gaaacgacag aagatgtaat tgttgctata gatttctcta tacatgaagc aaaacgctct
     1141 gagtcaaggc gagttgttta tgcagatgcg tctataagtg aaaagataaa gaagaaacat
     1201 gttattaaaa attgtttaaa agaagcatta aaaaatgatg ggtttgaagt gtactaccaa
     1261 cctatatttt ctaatagcag gggcaggttt acttcagcag aggcattact taggctagaa
     1321 cacaaagagt taggttttat acctcctgat gaatttattc caattgcaga acaaacagga
     1381 ttgattaact caattggatt agtagtcttt gagaaggtat gtagatttat agctagtgat
     1441 gagtttgaag atttaaaatt ggataatata gctgtgaatc tttctgtagt acaatgtatg
     1501 caaaaaaact tagctgatga tttactttat cttatgaata aatataatgt atcaccaact
     1561 aaatttaaac ttgaaattac tgagactgtg gctatgggct cttttaatat aattaaagaa
     1621 acaatggaaa gattaattga tttaggtgtt aagtttgcac ttgatgattt tggaattgct
     1681 tattctggag ttactaatat gctttcttta ccattttcag taattaagtt agataagagt
     1741 ttgatttggt ctatgaatga agatagtagg cataaactta cagttgagac gattatagca
     1801 cttataaata aattgaatat gaaggctgta gcagaaggtg ttgaaaccat taagtgtgct
     1861 gaagatttaa tagctatgga gtgtgaatat ttgcaagggt attatttttc taaaccagtt
     1921 ccagaagatg tttttaaaaa tttgttgaaa gaaaatactt ttacaagtta acacccttta
     1981 tttttttaat tacaactttg ttcattgaca ctgccagcga tatattataa aattaacaca
     2041 ataataaata ttaaatttat tatacatatt attaatatta attaatggag taaagattta
     2101 ttatatattt tatttaatta tcctaaagtg agaaaggaag atgtgacatg aataaaaaga
     2161 aaatattagt gccaattgat gggacagaaa gaagtatgca ttctttggaa tttataaaag
     2221 gaatatttaa aaaagatgaa gttgaagtag aaataatgaa tgtaaaagaa ctagtattta
     2281 ttgatggcat atccctggct gaagagataa aaaattctga aaatttagga agaagaatct
     2341 tggataaagc agcagagata atgggagagt atgatgttaa agtacatttt acttttggat
     2401 atccaggaga tgagataatt agaaaagcaa aagaagataa tgtagatttt atagttatga
     2461 caaaatctac taaaaaaggt cttacaagaa tgataggttc agtaacagca agtgtagtta
     2521 aacaagcaaa atgtatagtg atgattgtac cggagtagaa ttagaaaggt atttgaaata
     2581 tgaataaaaa gatagtagca gtttgtgaaa gtgaaagaag tttaaattct cttaagacag
     2641 ctgcaaatga tttaggattt gatttagttt atgaaattca agaaaatgat aatataaaaa
     2701 atgaactttc tatttatgat atagaagatg catccatagt gttatttgtt acaagtgatt
     2761 ctatagaaag catagagaag attgatagat ttatagatag agaattttat gaagttgatc
     2821 caaagtatat aatagaggat gcaaaatcta tagtaagtga aattttaata gacttaaatt
     2881 aatcgtgggt gtcgcactaa gaatagagcg acgccttttt atatatttta cacaagaaat
     2941 aaagaggttg tatcaaaata tagataagag tctttttcat tgttgaaatg atgaaaatat
     3001 atttgatttc atacaaaaaa gagtacctca taactaaaaa gttcactttg agacactcca
     3061 tttttatatg ttagttgcat ttaaggtaaa atagaagttt aatcatgttg aaataactga
     3121 attacatctt ctaaatgatt gtacattgat gtataaccta agtaagagtc tttactatca
     3181 aatgcaatca ttatcttgtt atggtggcta atcatatcct tgagagaatt tctatattta
     3241 aaaccaaagt attggttaga agaaactgtt ttaggtatta actcataata ttttataaaa
     3301 attggattat gagaagctaa aattatctct ttgtgaaatt gcaagtcagc atcataacat
     3361 tcttctatca aaccatgaga aaccttatcc aattcctcta ttgactttag gtaagtatat
     3421 tttatttttt gaagttcttt agatgtagca tttaaaattg ctagtttagt agcttcgctt
     3481 tcgataagtt gtcttgctct taaagattct acataaaatt cttgtatgtt atgattttta
     3541 tagatttcac catcatcaaa taggtcaact tttttaaatc cttcaactat aggacttgaa
     3601 taaggcacag ctctaagtat tccttcctta cagagtatat ttatggcatt tcttacaggt
     3661 attctactta tgttaaatag gtcagcaatc tttctctcac ttggtaattt actattaatt
     3721 ttaaaagttc catttagaat gtttaattta atataatcaa taattttttc agtggcattt
     3781 aagcttttca taaaaactcc taaacatata atttttttat gattgtatta tatcatagtt
     3841 aagagttaaa tctacttttt tataatatgt ataagacagg atagaggcca aaatagctat
     3901 aatagccaag ataaagtatc catattgtat tgaagtatat tccgatattt taccaactat
     3961 cattggaaat acagacattc ctatagcata aattgcttga aaaaaaccca ttgcagtaga
     4021 tttctgatgt tttggtacat ttttcataga ctcgctagta aggtaagaaa ggagtatacc
     4081 tgtagatata cctggtagta cttgtagtac aaatattata ttaatatttt ttattgttgg
     4141 aactaaaaag caataggctg aaactaaaat aaaaactaaa ggaatccaaa attttggtcc
     4201 atacttagta caaaatttag tagaagcaaa gccagaagaa gcaacagcac acaccatgta
     4261 aaatatagaa gatagaccta tgagggtaga actagaacct aagtttttaa gaatttgagt
     4321 agtaaatgac attgttgtag acatttgaat accctgttga attaatgcca taaaggaaaa
     4381 aaatacaagt cttttatcct tgcagataga taaatatttt ttaattgata ttttttcagg
     4441 tattttttta gaattatgat tttttatatt taaggctaga atcgttccaa taactgaaga
     4501 caatacactc atgatacata aggctgtcat tcctaatttt tcataaaata aagtactcat
     4561 aacaaatcca atcaacattc ctagattgtt taccaatatt atcgtacttg tagctttttg
     4621 ttgatgttct gtagaaaaaa agttggtata gtgaaccatg taagaaatcc aagttgatga
     4681 tgatattcca gataaaatgt tagctataag aaaaccattg cctccaggag aaaagactct
     4741 tataagagat gctaaaccag caaagaaaat tccagacagt ataaatattt tatgtttatt
     4801 tatggaatca gcaaatactc caacaggaag ccttaataaa cattgtgata ttccatatgc
     4861 acctattatt ataccaatca tatttgtaga tacattacat gcacttaaat atggattttg
     4921 gaaaggtata tatacatatt gtgaaaacca gaaaaatgta acaatagaaa gtaaaagtaa
     4981 tttttgatta gatatttttt tcatattatc ctccatgtgg tatttttata atgcaaataa
     5041 tataccattt agatttttta atcaagtact ttctctatta aaaaaaattt aaatatataa
     5101 ttattattta caaaaaaatt atactttata gttgaattaa gaaaacgctt atgatactat
     5161 aaagttaaca aatttgaata tataacagta gacgtgttac tggtaatgca ggcaagatcg
     5221 aatcaatttt tatagattat ctatagagta ctatgggtat aatctattta tttggttcga
     5281 tttttttgtt taattggcca taaaacaaaa agcctatagt tgaaaatgga ggatttttta
     5341 tggattataa aaatatagct caagaaattc tactaaatgt aggaggaaaa gagaatgtaa
     5401 atgaagtgac tcattgtatg acaagactta gatttaaagt caaaagcgct tctaaagtga
     5461 ataaggataa attatctaaa actgaaggag taataactgt tgttgagagt atgggtcaaa
     5521 tacaagttgt aattggaaat aaagtaaaaa aagtatatga tgaggtcata aaaattgtac
     5581 ctcaatcaaa taacataggt aaaaagaatg aaagtcaaga aaagcaaggt ataattaatt
     5641 ctatattatc agcagtagct ggtatattta cacctacaat acctgctata gcaggggttg
     5701 gtatgattaa aggtatttta tcagttcttg ctatgtatta tatgaataaa aatggagtag
     5761 atataaaaga aacgcaaagc tatattatct taaatgctat ggctgattct atattctatt
     5821 ttatgcctat tatactagga tatactgcgg ctaaagtatt taatgcaaat aaaataatat
     5881 ctatggtatt aggagctaca ctttgttatc caacttttac tgctttgatg gcaggtgaag
     5941 aatctgttag atttttagga ttggcagtaa caaaagctac gtatacatca tctgttattc
     6001 caataattat tgctatatgg gctctttcat acgttgaaaa agtattagaa aagtatatac
     6061 ctgaggtaat taaaataata atggttccaa ctttatcatt ggtagtaatg ttacctgcaa
     6121 cattattttt atttggacca atcggaattt atataggaaa tgtcataaac ttttcttata
     6181 agtatattta tgaattaagc ccagcattgt gtggagcatt tgtaggtggg ttatggtgtg
     6241 tgttagttat atttggtgct catagagcat tattaccaat aggtataagt gatgttgctc
     6301 aaacaggaag acaaaattta ttggcgtttg caggagctgc aaacttttca caagcagggg
     6361 ctgctctagg agtattcttt aaaactaaaa atcaaggact aaaaacaatt tctatgtctg
     6421 caactataac agctttattt ggtataactg aacctgcaat atacggtgcc aatcttagat
     6481 taaaaaaacc tatggtatgt gccgtaatat gtggtgcatt tggaggtgcg ataatgggaa
     6541 tgggtggagc ttatggtaat gcatttgcaa accaaggtgt tttaactata cctgtatatg
     6601 ctgaagcagg tgcattaggt ttcttaagtt atctaggtgg ttgtgctata gcattttttg
     6661 gttcagctat ttcaacttat ctagttggat ttgaagattt ggaagagtct tctaataagg
     6721 aaaattcatc tataaaagta gaaacgaagg atggtgttat tgatataact tcacctgtag
     6781 agggcgaatg tatagaattg tcagaagtaa aggatgatgt atttgcttca aaagctatgg
     6841 gagaaggtat agctgtgtta cctacaaaag gagtaataac agcccctact gattgtgaag
     6901 tagcttcttt atttccaaca ttacatgcaa taggattaaa attagataat ggagcagaaa
     6961 tgttaataca tgttggaatc aatacagtag agttaaatgg taaatacttt acaaaacatg
     7021 ttaatcaagg agatttagtg aaaaaaggtg ataaacttat atcgtttgat atagataaaa
     7081 taaaaaaggc tggttatgat gtaactacgc cagttatagt aaacaataca tttgattttg
     7141 ggcaagtagt ttcttgtaaa tctagttatg tttcaaccaa tgataatata atttcattag
     7201 tattagctgg taattaagtt aatttgacta gagataagta aattgattta aaaggaaata
     7261 agtaaatcaa caattaaata catctaaaag taagtttatt gcaatgaatt gttaaagaaa
     7321 ataattaata tggagtaaat ctattgcaat gaagtaacaa agaaaataat taatatagag
     7381 taagtttatt gtaatgaatt gttaaagaaa agagttaata tagagtaagt ttattgtaat
     7441 gaattgttaa agaaaataat taatataggg taaatctatc tcaatgaaat aacaaagaaa
     7501 agagttaata tagagtgaac ttattgcaat gaatcaacaa agaaaataat caatataaaa
     7561 aggagaaata tttatgaata caggatttcc aaaagacttt ttatggggag catcatcttc
     7621 tgcatttcaa gtggaaggag cttgggataa agacaataaa ggaaaaaccg tagccgacta
     7681 taattctttt aaaaagtctc atttacaggc agatactaaa gtcgcatcag acttttacca
     7741 taattatgaa gaagatattg aattaatgaa agaattaggg atgaaaacat atcgtttttc
     7801 aatttcatgg gcaagaataa taccagatgg tgaaggagag ataaaccaga aaggtttaga
     7861 attttataat aagataatag acaaactgat agagtgtgat attgagccat tcgtaacttt
     7921 ataccatttt gaccttccat ttaaattagt agagaaatat aatggttggg aaagtagaga
     7981 aactgtctat gcttttgaaa gatttgctaa aatatgcttt aagcattttg gagatagggt
     8041 aaagtattgg caacctcata atgaacagaa tttaattgtt agagtggagg agagaattaa
     8101 tatatatgat gaaacagatt catggaagat agataaaatg cgtgctcaga tggattataa
     8161 tctttgctta gcacatgcat tagcagtcaa tgcatgtcat gagatgataa aagaaagtaa
     8221 aattggagca gcagtatcat catctgtaac atatcctctt acttctaagc cagaagatgt
     8281 atatgcagct agaatgaatg ataattttaa agtgtactat atgcttgata tgcatcatta
     8341 tggagaatat ccagggtatt atatgaagta tcttgaaaaa agaaatatag ttcctcacat
     8401 ggaagatggg gataaagaga tacttaaaaa agctaaaatg gattttatag ctgtaaatta
     8461 ttataggaca aattgtgcag aagctttacc tgaagattca caacatccat ttggattaag
     8521 agaaggaact gttgatttta gtatgtatgg actatttaaa atgtcaatga atcctaactt
     8581 agaggcttct gagtatggag cagcaataga cccatcaggt cttagagttg ccttaaatga
     8641 atattggcaa agatatcact tacctgttat aataacagaa aatggtctag gagctaaaga
     8701 tatattagaa gatggaaaaa ttcatgatga ctatcgtata gactatttaa gaagtcatat
     8761 aaatgcatgt aaactagcta ttgaagatgg tgtagagatg attggatatt gtccatggtc
     8821 atttacagac cttttaagtt cttctcaagg ttttaataag cgttatggac ttgtttatat
     8881 aaatagaact gaccatgaag ttttagattt aaaaagaatc aagaaagata gtttttactg
     8941 gtataaagaa gttatagaga acaatggaat agtaaaataa acataaatat atattgaggg
     9001 ttttagtatg tacattacaa aggtattaaa taattcgttg ctacttgcaa aggatgataa
     9061 tgatgaagaa ataatattga tggggaaagg cattggccat aattataagg ccgggtctga
     9121 gttaaataaa aaagatatag aaaagatttt tgttcttcat gatgaaaata taaaaaagag
     9181 tattatacaa ttggcaacag aaatagatgc agaatatttt ggtatagctc aaatgataat
     9241 tgcatatgga atagaaaaat ataacttaaa acttatgaac catatatatt tggccttaac
     9301 tgaccacatt gcctttgcag tgagacgttt taaagaaggt ataatgattg aaaatcacta
     9361 tttgttcgaa atcaaggaat ttaatccaaa agagtatgat ataggaaaat atgctattac
     9421 tgtttttaag gaggttcttg gtttagacct accagaagaa gagattggta atatagcagg
     9481 ccattttata aatgcacaac aagataatcc ttatagtgat agaaataaga gaagtgctaa
     9541 aattgtaaat gctattttgc aaatagttca ttatcacttt tctattgtat ataataaaga
     9601 gtcattttat tataggagat ttgtaatgca tctaaaggcc ttttcacaaa gatttctggc
     9661 taatgaacca tcaagagaaa aaatagattt tatatatgag caagttcaaa aaaattgtaa
     9721 ggaagagtat gaatgtgtga aaaaggtagg agcttatatg tataaggaat actccagaga
     9781 attaccaaga caagaggagt tatatttgat gattcatatt cataagattt taggagaatt
     9841 atgcgaaaat agttagaata tcttaatatg ctagtaatat tataaaaaat taaaaattaa
     9901 ctgcacttta aatatgaata attgcattac ttaagggggt tgtcttaaaa ttgatttttt
     9961 taattaaatt tgaagctcaa ctcctttttt aaacctttat atcattacaa ctttaatgtt
    10021 tatacgactg tactttagat gtatatctac tttttacatt tctcaacatg caaacctacc
    10081 attttttgca gtatgttaat tgaaataaac cattgagtta accctaaatt tattctggac
    10141 ttataggaat agttccaaag atactttaaa atattttctg gaataattgc ttatttcaca
    10201 tatgttttat tgtgatgttt tgatttaata aattcttcaa ctctgtatat agtaaatgta
    10261 ttatcatgtt tgttttattc aagcacactt ataatacgct tgattttttc acaatgatga
    10321 aatatactaa tgggtgttat aggtataaga atcgcattac acttgaagaa gtaagtgata
    10381 aatgaggtat aaatcctcat atgataaact actatttcat tgaggaacat attctaagtg
    10441 atgtcaagat actacaatat gactaaattc ctagtgataa aaaagtctac gaatgagtgt
    10501 agaaagggga actaagatga ataaagtttt aattatagat gatgataaag atctttgtat
    10561 tttgttaaaa aagagtattt caattgaaca gattgaagca aactattgcc attctgggag
    10621 agatggactg gttgaacttt caaaacaaga ttatcagtta gtagttctag atgtgatgat
    10681 gccaggtatg gatggttttg aaactatgga acaaatacga aaatatagca gtattcccat
    10741 cttaatgctg acatcaaaaa gcgataatta cagcaaagtg catggattgc gagctggtgc
    10801 agatgactat ctaaccaaac catttgaaat tacagaattt actgctcgtg tactgtcttt
    10861 aatccgacgt tacacccgtt ttaatccaaa aaatgaggag ccacagcaac tttctttcaa
    10921 aggtttgttg attgaccttg accagcatac agttactacc aatggcgaac ctatgttgct
    10981 tccacccaag gaatttggtg tacttcttta ctgtgcaagg catcagggta agattttgac
    11041 aaaacagcag atttatgaag ccgtgtgggg tgagccatat gtatatgatg acagcaatat
    11101 catggctatt atcagtcgcc taagaaaaaa aattgaacta gacccatcat ctcccatcta
    11161 tttgcaaaca ataaaaggaa ttgggtatca attcaacacg gaggtatgaa aatggatgaa
    11221 caaacgataa ttcttttctt actcttgctg tcgattggtc tactttttct ttccatattt
    11281 gctttttcca agcttgggca tatttacaag cgcctaaaag atatagagga gatactggct
    11341 gatgtacaaa ttggagacga aaatcgtaaa atactaatta agccatgtga tgttatggct
    11401 ccattggttt atcagcttaa tgagattgtc tacgattatg aaaataagtt actttctctg
    11461 aaaaagtcgg ataaagctag caaacaactt atgacaagtt tatctcatga tgttcgtaca
    11521 ccattaacaa ctctgattgg ttatctggat gctgtacaca gtggtatagt tatcgaacaa
    11581 gagcgggagg aataccttga aatcgctagg cgtagagcct acgacctcaa ggattacatt
    11641 gatgttcttt ttgactggtt tcggttgaac tctgatgaat ttacgctgtc aatagaatct
    11701 gtggaaattg cagagttgtc acgcaatatt ttgaaagact ggattcctat attccatgaa
    11761 aagaaactga attttgaaat tgatattcca gaaaatcgac taatggtaaa cctcgaccca
    11821 gatggatatt cccgtgtggt caataatctg gttcaaaatg ttcttgctca cagtaaggct
    11881 cggcaaatca agattaccat gagtgaggat tccagaatgg tattactccg tgttgaggat
    11941 gatggtgttg ggattgccag agaaaattta ccacatattt ttgagcgact gtataagtgt
    12001 gataaaggac gttcagaaaa aggaagtggt cttggtctat ctattgtcag tcaaatggtg
    12061 gagcgaatgg gtggtcaggt ttccgtagaa agtgagattg gaaagtatac cgtatttaca
    12121 gtgagcttac cattaatata aaattgtttt tcccccatgt gacatgtata cacatgggga
    12181 ttttttgtaa gttataaagt tgcaaggtta atacaaggtt gttgcaaggt taatgtaaga
    12241 ttgaggtggt atgataactt taataaacaa aggaggcttt tattatttat gaataattta
    12301 attattgaaa caaaaaatct cactaagcaa tatggtgctc aaaagagcgt ttctaatttg
    12361 aatattcacg ttcagaaagg tcgcatttac ggattgctag gaagaaacgg tgcgggtaag
    12421 acgacaacta tgaaaatgtt attgggtcta acaaaaccaa ctactggaga aattaaaata
    12481 tttggtcagg acattcacaa taacgagaag aagcttcttc ctcgaattgg atgtttgatt
    12541 gaatcaccag ggttttatcc taatctgaca ggaacagaaa atctcaaaat ctttgcaagg
    12601 cttagaggaa taccaaaaaa aaatgcagta gaatcagcac tggatgtagt cggtttgcca
    12661 aacaatgaca aaaagttatt ttctcaatac tctcttggta tgaaacagag gttggcgatt
    12721 gctcttgcca ttatgcatga cccacaactg ttgattttgg acgagcctat caatggactt
    12781 gatcctattg gtattgcaga agtaagaacg tttattcgtg atctctgcac agaacgaggt
    12841 aaaactattt tgatttccag tcacattctt tctgaaattg ccttgttggc agatgacatt
    12901 ggcattattg accatggtat tttgttggag gaagaaagtc ttgcccaatt agaagaaaaa
    12961 aacagtaaat acatacattt tgctgtatct gatgcagcac aggcagcaag gcttctggaa
    13021 acccaactta acctgaaaaa tttcaaagta gcagataatt acaatattat gctatatgat
    13081 acagatgttt ctgttgcaga aataaatcgt gctttcattc taaacaacat tgaggtatca
    13141 gaatctcatt tatgcgaaga tactcttgaa gattacttca agaaagtaac agggggtgaa
    13201 ggaattgctt gatataattt catgtgaatt ttcaaaactc aagcggttaa aatttatact
    13261 gatttctatt ttaggtgctt gcttatttcc aattcccgca acaattttga ttgcaaagga
    13321 caacttgccc tttgagcaat tgttcaaatt agttgtcaat tttggatatt ttttgctatt
    13381 accaattgta ttaagtattg ttgctagcca actatttttt atagaaagag ataatgatgt
    13441 attaaaaaat cttgcaacag tgccagtgca aaaaggaaaa ctggctctgg caaaattggc
    13501 tgtgttgctg tttatatcat tgttctactc tgttgcaggg ttaggagcta ctatcattgg
    13561 aggtttcatt gttggaatag tagagggggt tgctgtaaaa ttaggaatga gcattgcttt
    13621 tggaattatg ttttttgtta ctgtacttcc tgttgtggta ctcattgtat atttcaatcg
    13681 cagctatatt ttttctatta tactttcttt tgtatatgct attttcaatt ttagtatatc
    13741 cttaaatatt atcaattttg aaccaaataa cccaatatta agtgtattac ctgctcctgt
    13801 tataatgcgt tggtggatgg cattttgggg agatcccact ggcgaataca cggcacttag
    13861 acagccatat ttgctctcaa ctcctgcttg tgtaggtatt ttatgtttga taaccattat
    13921 agcagtcctg ctgatttgta tgatatacaa aaagcaggag aattaggagg tatctatgct
    13981 tgatataatt actacagaat ttcaaaaaat aaaaagatat aatattctat ggattggtgt
    14041 tgttgctgtt ctgttttcag cactattggc agtttttcag gttgtaagtt cacacggcag
    14101 tgaccctcta acgtatgaga gctttgcaaa cggagttatc tggaataatt tcagtcttag
    14161 ttttccattt gggattacac ttattggagg atatcttatt aaccgtgaat atacagacca
    14221 aaccttaaaa aacatcctaa ctgttcctat ttcattacgc aaattgctag tgggaaaatt
    14281 aattgcggtt ggaggaatta ctgtattgtt aagtcttttc agcttcttat gcacatttat
    14341 tttggggttg ttgttttgca atatcaatat atctgttaca ctcgttgtaa aatccttagt
    14401 tcagattttg tctgttaatc tgtattgtta tgttgctgtt ttgccgatta ttgcttattt
    14461 tggtcgtaaa caaaatgcat ttctgacggg tgtagggatt gcatttgtat acggtttttg
    14521 tggtgtgttt gttgctggaa gaaatctgac agacttttat ccaatcacag caggtcttgg
    14581 tctagttgga tacaacaatg gtgctggtac tgtttatcag ccacttatcg gtgctatgac
    14641 tttgattgta attctaatct tgacaactat tctacttgta tttacaccta attatgataa
    14701 agttatgacc atatctaaga aaaaagggat aaagcataaa aagtattctc ataaataaca
    14761 taaatattgt ttctattatt taagttgcta gacagtgaaa agaaaaaatc tgtcgtacag
    14821 tgtctatatg ctcatgtatt caagaagcta cagttttgat ttttcataac tgtagcttct
    14881 ttttgtattt attaaatcac gactatcata atacttgcaa taggtatagc gacaagagag
    14941 agtactgtca tatgtgtttt atatattaca ttaagtatat tctaaaatat atgttttaaa
    15001 taatatattt gaaaatagga atatttaaat aaaaaaaata atattatata tagttgacaa
    15061 aaattggcaa atgagataat atataaatat agaaatagta atcattacta ttattaaaaa
    15121 gggaggaatt aattatgaac ttaaaaggaa ctaaaacaga aaagaattta atggcaggat
    15181 ttgcaggaga gtcagaagca agaaataaat atacatacta cgcttcaaaa gcaagaaaag
    15241 aaggttataa tcaaatagct gctatatttg aagaaactgc taacaatgaa aaggaacatg
    15301 ctaaattatg gtttaaactt ttacatgatg gtatgccttc aacagaggaa aatttaaagg
    15361 atgcagcagc aggtgaaaac tatgaatgga ctgatatgta tgcaaaattt gctaaagaag
    15421 ctagagaaga aggatttgac aagatagctt atttatttga agctgttgga aaaatagaga
    15481 aagagcatga agaaagatac ttaaagcttt tagaaaactt aaatgaagga aaaatattta
    15541 aaagagatga agaagttgtt tggcaatgtc aaaactgtgg tcatgtgtat gtaggtactg
    15601 aagcaccaga aaaatgccca gtatgtgacc atccaaaagc gtatttcaat ataaaagctg
    15661 aaaattatta aaaattatca ttattaaaaa ggaatgttaa ctatgaaatt ttctaaacaa
    15721 cgagaactga ttttaaatga aatattaaat aatccggttc atcctactgc ggattaccta
    15781 tatgaaaact taaaaaaaga taatccaaat ttaagcttag gaactgtgta tagaaattta
    15841 gctcagctaa cggaacatgg ctttataaga aaggttagta ttccagggta tccagataga
    15901 tttgatggtc gaatagataa tcactatcat atcatatgtg aagtatgtgg agaggtatac
    15961 gatttagaat ccgaagttct taataattta caagaattaa tatctgagga gacagacata
    16021 aaaataacat cttataacat aagttttaaa gggatttgta ataattgtaa aaggtgtagc
    16081 caagtaggtt agttttcaaa ttctaaaaat aattaatgag gtgagtttat gtgtagtgaa
    16141 caaaaatttt ttatatgtga gacttgtgga aaccttgtag gaatgataca aagtggtggt
    16201 gtacctattt tctgttgtgg aaaacctatg aaggaacttg ttcctaatac aacagatgca
    16261 gcagttgaaa aacatgtacc tgtaattgaa gtggatggaa ataatgttac tgttaaagta
    16321 agtagcacaa ctcatccaat gactaaagaa catcatatag catgggtgta tcttatgact
    16381 gaacaaggtg gtcaacgcaa atgtctagca gtagatggag aacctgtagt taaatttgct
    16441 ttgaatgatg atgataaagt gatttctgcc tatgcttact gtaatttaca tggattatgg
    16501 aaggctgaac tgtaatattt aaataaattg agtcaaaaag gaggctataa atgtattttc
    16561 atacaaatag cctcctataa atttatataa attcaagttt taattttgtt taatgtcaat
    16621 ataatataag gagaaaataa tatgtcaatt tataaatgta gtgtttgtgg atatatttat
    16681 gatgaatcta agaatgataa aacatgggat gaattaagtg aagattggga atgccctgta
    16741 tgtacaaaag gtcgtagtta ttttggaaag ataagtactg tttactatga agaagatgaa
    16801 aagatagcag aagacatagt tgaagatgaa tctaaattaa atactgaaaa agagggagat
    16861 ttaaattact taagtacata tttaagaaga gatgatgaag ttgagaaaca tatggatata
    16921 attcacgaaa tggctgttac aggaaaatct ataatagaac ctatgagaac taaactacca
    16981 gtaatttctt gggatgatat tttaattatg ggtgctcaat taaatccatt acctttaaat
    17041 gagcatgatg aagtaaatac aacaacaata ataggaaaaa aagcaaagaa acctatgatt
    17101 atagaaaatc cagtttatat ttcccacatg tcatttggag ctttgtctaa agaactaaaa
    17161 atagctttag caaagggtgc agcccaaaat aagacagcta tgtgtagtgg tgaaggaggt
    17221 atattaccag aagagaagga agcttcatac aagtatattt ttgagtatgt accaaataaa
    17281 tatagtgtaa ctgaagaaaa tcttaaaaat tctgatgcta tagagataaa aattggtcaa
    17341 ggaacaaaac ctggtatggg aggtcatctt cctggcgaaa aagtaactga agaaatagca
    17401 aaagtaagaa ataagcctgt aggtcaagat gtaataagtc catcttgttt tgaggaaata
    17461 caatccaaag aagatttaaa gaaacttgta gatgaactta gagaagtttc agaagggcgt
    17521 ccaataggtg ttaaaatttc agcaggtcat attgaaaaag atatggaatt tatagcttat
    17581 gctaaacctg attttgtaac tattgatggt cgtggtggag ctactggagc aagtccaaag
    17641 ttgcttaaag atgcaacttc aattccaaca atatttgctc tttatcgtgc tagaaaatac
    17701 atagatacac atggattaga tatagatttg gttataacag gtgggcttcg tatatctact
    17761 gattttgcta aggcaattgc tatgggtgct gatgcagttg ctattgcaag ttctgctctt
    17821 atggcagcgg cgtgtcaaca atatcgtata tgtggttctg gtaagtgtcc tgtaggagta
    17881 gctactcagg atgaggaatt gagaaaaaga ttacatatag aaaacagtgc taatagagtg
    17941 gcaaactttt taaatgtaag tttagaagaa cttaagactt ttgctagaat ttctggtcat
    18001 aaagatatac atgatttaag tgttgatgat ttatatactg ttaactctga aatatcaaat
    18061 tatacaaaca tacagcatgt atagattgaa gtttgaaact attagatttt agatagctat
    18121 aaaagtaaat gataaatata ttttataaaa gagagtgtct taaaatgaac tttttagttc
    18181 ataagtcact ctttttttta tgaagccaaa tatatttatc attttagcaa tgaaaaagaa
    18241 tcttatctct ttattttgag atagactcct tctatttatg aaaattaaag atattaaatt
    18301 gtaaaatatt ctgtgatgtc gtactattaa actaaagatt ctgtacttta aagtaaataa
    18361 aaatttaagg agtgattatt atggaaagat tgaagataca agttttagtt gacaataata
    18421 cttatattga tagatacttt gttggagaac cagcagtaag ctattatatt gagattgatg
    18481 gaaataggat tttgtttgac tcagggtatt cagatgtatt catatcaaac gctgaaaaat
    18541 taaatataga tttaggaaat ttaactcatg ttgttttttc tcatgggcat aatgaccata
    18601 caagaggtat ccagtttcta gaaaataggt atgatttatc tacagttgaa cttatttcac
    18661 atcctaactg ttttatacct agaaaacatg gagagaaaag cataggagct ccattttctg
    18721 ctgaggaaat taaaaatatt tttatgtata atcctaagga taagccattt aatctaagta
    18781 agaattgtgt gtttttaggt gaaatacctt ctataaatga ttttgaaaaa agagctaaaa
    18841 ttggtaaatg taaaatagga gatttgtggg aagatgatta tgttttagat gattctgcta
    18901 tagtttgtaa aactgataaa ggtattttta ttgttacagg atgttctcat agtggaattt
    18961 gtaatatagt agagtatgct aaaaaggtat gtggagatga tagagttatt ggtatactag
    19021 gtggttttca tctttttgaa ttgaataata ggttagatag tacaatacaa tatttggata
    19081 aagaagaaat gagaatgttg tacccttgtc actgtgtttc ttttaaggta aaagcgaaga
    19141 tgaatgaaat attgaatata aatgaagttg gagtagggct gaccataagt atatagtatt
    19201 tgaaagtata taagatttaa gttgaaggtt aaaaagatat tttctataga aaatatcttt
    19261 tttgttacgt ttattttaag agaaatcaat atacttttat atgaaatatt gtaaaaaaat
    19321 ttatttttaa tgagaatata
//
LOCUS       DAEHWM010000081        19282 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.082, whole genome shotgun sequence.
ACCESSION   DAEHWM010000081 DAEHWM010000000
VERSION     DAEHWM010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19282)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19282)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19282
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.082"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            58..1071
                     /gene="aroF"
                     /locus_tag="KNP36_002819"
     CDS             58..1071
                     /gene="aroF"
                     /locus_tag="KNP36_002819"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HBF0874678.1"
                     /translation="MIVVLKMGADKNEVKKLIEAIGREGVEVNPIDGTELTVLGLVGD
                     TSKIDAKRIEANKVVEKVMHVVEPFKKANRKFHPEPSIINVNGMEIGSKKIAMIAGPC
                     SVETEDQIVSIAKDVKKSGAGFLRGGAFKPRTSPYAFQGLKYDGLDLLKKAKEKTGLP
                     IVTEIMSTQDIDIFEENVDVIQVGARNMQNFDLLKELGKTNKTILLKRGLSATIEEWL
                     MSAEYIMAGGNENVVLCERGIRTFETYTRNTLDLSAILAVKKLSHLPVIVDPSHAAGK
                     SWMVDSLSKAAIAVGADGLIIEVHNDPAHALCDGKQSIKPNEYDELISELKTIASAVG
                     REI"
     gene            1093..2157
                     /locus_tag="KNP36_002820"
     CDS             1093..2157
                     /locus_tag="KNP36_002820"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423904.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HBF0874679.1"
                     /translation="MEEKLLVNLKENSYNIFIKKNILKNIGEEIKKIYFGNKIFIVTD
                     ENIAKLYLDKVKNNLSESGFEIKSLILKSGEETKSFNTLPKIYDSLLDFKLTRKDLII
                     TLGGGVIGDLGGFAAATFLRGISFIQIPTSLLAQVDSSVGGKVGVDLERGKNLVGSFY
                     QPKAVFIDPNVLLSLPEKFYRDGMAEVIKYGCIKDKTFFNKLLSLKNREEVMQHIEYI
                     IHKCCFIKKTVVEADEKDFGDRMLLNFGHTLGHAIEKYYNFTGYTHGEAVAIGMYKIT
                     LESEKIGITKKGTSELIKSILMNYNLPYEIELRDNKSIVDAISLDKKNLGDTLKIILL
                     KDIGESIIYNTTSKFFQEVR"
     gene            2157..3470
                     /gene="aroA"
                     /locus_tag="KNP36_002821"
     CDS             2157..3470
                     /gene="aroA"
                     /locus_tag="KNP36_002821"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HBF0874680.1"
                     /translation="MGSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNID
                     FSDDIIATIRAMTSLGAIIEKKEDILEISGIFSKEGILNRENQLNQPKLTIDCNESGS
                     TLRFLVPISLTFDGVKRFIGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKL
                     KPDEFRVKGNISSQFITGLLFILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEI
                     INNNYKEFIIKGNQTYKARDYKVEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSE
                     VVEILSRMGMEILREGNKIKGITNGLNGTLIDASQCPDIIPVLSVVASLSIGRTTIIN
                     AGRLRIKECDRLHAINVELSKLGANIEEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMT
                     LAIASCRCDKPIILKDFECVSKSYPHFFKDFKMLGGRIDEWNMGK"
     gene            3448..4527
                     /gene="aroC"
                     /locus_tag="KNP36_002822"
     CDS             3448..4527
                     /gene="aroC"
                     /locus_tag="KNP36_002822"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HBF0874681.1"
                     /translation="MSGIWGNNLKVSIFGESHGNAIGINIDGLPSGIELDLDNIDKEM
                     KRRAPGKNSISTSRNESDIPEILSGYFNGRTTGTPLCAIIRNSDTRSKDYGELKNLMR
                     PGHADFTGNVRYSGFNDYRGGGHFSGRITAPLVFCGAICKQILSQKGIEIGAHIKKIK
                     NIEDMSFDYVNISKQQLSNLQTLELPLLDLSKEEAMKNTIIDAKNQGDSVGGIIECAV
                     VGINVGLGNPFFDSVESTLSHLLFSVPAVKGVEFGLGFELADMYGSQSNDEMYYEGNQ
                     VKSKTNNNGGIIGGITTGMPIIFKVAIKPTPSISRQQNTVNIKDKKDDILYIKGRHDP
                     CIVQRAIPVIEAVTAIGIFDLMKGR"
     gene            4530..5726
                     /gene="pheA"
                     /locus_tag="KNP36_002823"
     CDS             4530..5726
                     /gene="pheA"
                     /locus_tag="KNP36_002823"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HBF0874682.1"
                     /translation="MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTIL
                     QKDREEKVLSRAVDNLDNKAYSQETVQFFNSIMEISRGLQKRLIDNDGEQKIEFSLDS
                     SNKKFDLSNVNRYKSLKDELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFE
                     DVFIALKNKEINYGIIPIENSSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDT
                     KLEDIKEIYSHPQGIGQCSKFLKQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKK
                     AASIYGLEIISPCINDIANNYTRFVVISNQIHIEEESNKMSVVFSVEHEAGKLYKVLG
                     YFAKNNINMTKIESRPMKNASWRYFFYIDFECSIYNAKVYDLLELIEHNTAYFKFMGV
                     YKNKTE"
     gene            5773..6582
                     /gene="aroE"
                     /locus_tag="KNP36_002824"
     CDS             5773..6582
                     /gene="aroE"
                     /locus_tag="KNP36_002824"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HBF0874683.1"
                     /translation="MNFFGLVGEKLSHSVSPQIHKRVFEILNIESAYKNFEISKEDIS
                     KLDGAIKLLGIQGVNVTVPYKERIMKYLDFISPEAKRIGAVNTILLRENMLYGYNTDY
                     FGLDSMFKMANIDVQGKVAVILGTGGASKAALTYFIDSGIEKLYVSTRKKDDKKLLNS
                     KAILIDYEELKHIKGDIILNATPVGMYPNVGISPVSKSIIQNFDILIDLIYNPGETEF
                     LRIGNSMGKKTCDGLYMLVGQAIKSQEIWQDTKIDNSILDVIYNELKLEFL"
     gene            6594..7127
                     /locus_tag="KNP36_002825"
     CDS             6594..7127
                     /locus_tag="KNP36_002825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HBF0874684.1"
                     /translation="MINKTKEKLILIGMPGSGKTTIGKLLAKEYNCSFCDMDDYIIQI
                     SQKSIAELFSEGEDIFRNYETQACRELSISDKTVISTGGGVIKKDVNMEILKETGIII
                     FIDRPIQKILEDININSRPLLKNGKDRLYNLYNERINLYKKFSDIEILNDKSLNNAVY
                     NITNAVSENFKFDFKEK"
     gene            7148..7987
                     /locus_tag="KNP36_002826"
     CDS             7148..7987
                     /locus_tag="KNP36_002826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HBF0874685.1"
                     /translation="MNIVIVGLGVIGGSFAKALKKAGYENVFGVDVDLETLKKAEKAK
                     IIKKGCTTGKELFKKADLIILSIYPRLVVDFLNNNKNFFKKGTIITDTTGIKETLIND
                     VLQIIPDDIDFIFGHPMAGREKKGIDFASEQVFNGANYIITPTGRNNIKNLELVENLI
                     LEIGFKRVKKLTSQKHDEIIAFTSQLPHVMAVALINSDEEGRDTGKFIGDSYRDLTRI
                     ANMNEDLWSELFLGNRDNLLKVIENFESEVNLVKEAIFNNDKNKLIEYFKKSSIRREA
                     LEK"
     gene            8255..9736
                     /locus_tag="KNP36_002827"
     CDS             8255..9736
                     /locus_tag="KNP36_002827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBF0874686.1"
                     /translation="MKKNRLIAKNISIAFIVLFFFSVFTFFYVGNINRVLEYETNDII
                     TVTIAGWIILSFLFLGIIIYILYSKANSQKTIEKVAYTDFVTGYSNWRKFELDVTNLL
                     KKTSQNNKYAMVIFDIDKFKAINDIYGHKKGNLILKDIADTLNELTDINETFARVSAD
                     NFNILLTYNKKEDIINIIKKIMANNELVNLSFGIYEIKDKDLSVSVYSDRASLAKSSI
                     KNNSDVNFAFFNDKLREKLLFEDKIEKEMEYALESGQFVMYLQPKYNIKLDKFCGSEA
                     LVRWQYTEKEVIYPGDFIPIFEKNGFIRKIDMYILEQACKEIRSLFDKGISPLPISVN
                     FSRVDFFKKDFIENIVNICDRYKIPYSLIEIEITESSMFGDTDTLFNVSRNLQDIGFI
                     VAMDDFGSGYSSVNMLKNIPLNVIKLDRGFFVDDKDVDKSQIVIKSIVSLIKQLGIRV
                     VAEGIETRSQIEMLKKANCDIVQGYYFSKPLPIKEFEKLVYKI"
     gene            9769..13203
                     /locus_tag="KNP36_002828"
     CDS             9769..13203
                     /locus_tag="KNP36_002828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing protein"
                     /protein_id="HBF0874687.1"
                     /translation="MIRAKSLKNVLSIVLIFLFTIISFSDFAFKTNVQEEENSKINLR
                     EISLQSSNAIKIKLDSSLSFIKSVANMVSYFNTIDNSKIVPLLANISKESDFQRISIV
                     SPDGISHTSDGKIINVSKYQYFKKAIKGESNISEVVKSPIDGKDTFVIATPVFNKNNK
                     IIGVLYGSYYNDKLAEFIDITSFNSEGYIDIFESSGQFVLKSSHTNKLIKSSSNIYDI
                     FKKASFDDGYSYKKIYEDTKNNKSGFTSYEYKGENRYATYTPIGVNDWYVISVIPQYT
                     VRRNIDKINQLAFSLIFKVFLLFIMLIIYIIYKNNKSQKDILKANKEISSITNSIPGG
                     VQKCTLGETCNINFLSDGFIELFGYTREEIKTLFNNDFYSLIHKDDVERIKKEIFKQL
                     YKNKTVELEYRIITKNGNTVWVLDKGELITEPDGKEYFCCVTVDITRTKQLEQEMEQK
                     NLELEMISENVLGGIIITEFNDDFTIKYANSGYLSMIGYTREQLENELKYKACNLVFY
                     EDKKKALESIQHQLNTKGIAVYQHRIRRRNGNIIWVSIKGRLIVDDGIEKGIWILNDI
                     TDLKNAEQKLKINEERFRIALKQTSNTIFEYDIKTKSLLNTSKELDKYNIYKITKNVP
                     YSLVESGVIHKDFSDDFINMYENVINGAKKASCVVKMKLPDENYIWNKVTLTTIFDED
                     GNPVRAIGIQEDISKQKEAEIRYNQEGKYHSAILSEAMITYEINVSKDTFIKGNESWQ
                     KPFGIKPDNNYSQMVKTIANSIVHKDNKETFLNTFLCENLLDAYKNNVTEIKLEYRRM
                     NQENKMIWVICTMHLIKDSITNDIKALAYVKDIDKQKNEEIRLKLKAERDTLTGLYNK
                     GTTEKLINDFLNSEEASLGMHAFLIVDIDNFKSVNDNLGHVFGDKVLFEVSKNLKPIF
                     RKDDIVGRIGGDEFIVFLKNIQSFENIKKKAEKICDIFRNSYTENKKTYKISGTVGIS
                     FVPEHGTVFEELYKKADIALYYAKSKGKDKYALYNDCIYQNELENNISDNNIKLADKC
                     EKSKPVLKEILDSIDNYIYIVNPNTYELLFVNNKVSRLDLEIKLGETCYKSLLKSDRP
                     CNNCPLNGLEENKHSKFKIETNTFGKNISIASWINCIDGEYNCLIECIDSSLYKNK"
     gene            13221..13967
                     /locus_tag="KNP36_002829"
     CDS             13221..13967
                     /locus_tag="KNP36_002829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcF family protein"
                     /protein_id="HBF0874688.1"
                     /translation="MLNSITLILGIIFTIYYFYLKIVFGGISFSEIFLVVGIVLIIYQ
                     IFKKKIKEKKVFYRVLKIIISIFLIVFVVTESLIIFYPKNSLESKSDYLLILGASVKK
                     TTPSTTLKGRLDTALKYLKINDNCYVVVSGGKGSGEKITEAKAMKDYLIKNGIDKNRI
                     IEEDKSTNTYENFKYSKLKIEEHSQGKLSDLKVKIVTTDFHVLRSKILAYRNGYKNTS
                     FYASKSKLSFVPTYYTREFFALWKTIIFDR"
     gene            complement(13916..14224)
                     /locus_tag="KNP36_002830"
     CDS             complement(13916..14224)
                     /locus_tag="KNP36_002830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxamine 5'-phosphate oxidase family
                     protein"
                     /protein_id="HBF0874689.1"
                     /translation="MNFFKENSTFYFATVEDNKPRVRPFGFIMDYEGKLYFGIVKYKT
                     SYKQLLVNPNVEISTTSKVGKWIRIKGIEKTRYEFISSLFIYYLSKMIVFHNAKNSLV
                     "
     gene            15028..19170
                     /locus_tag="KNP36_002831"
     CDS             15028..19170
                     /locus_tag="KNP36_002831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466370.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF11 domain-containing protein"
                     /protein_id="HBF0874690.1"
                     /translation="MATVSGQIVFDRNRSATIDSGDSGIANIPVVLQDIATGVRLVVL
                     TDASGNYVFTNVPNGNYRIVEAFGTTGGVPTPGNFATAIVGPVPIAEMPPISSVTSPP
                     IGSTNLDGTTPNTLLITVAGSDITNQNILNGPVIYTPIENILDSCVSVSNINLITDAD
                     NGTFGFFPPGTPSNTGPEIEPYPNVTPDFTYVVPDPTKFTPLDGEYTVQNIMTNAMSN
                     VIGAWWRIADHTTGNETGRMMVVNGFNPGAVFFKSTVQVTPNTNYLFSTWILNLFKVT
                     GYPPPQLGVRIFDQNNNILYQATLGAQIPVNTNAPEWKEVGTVINSQNNNQLTVEFFS
                     EGESAIGNDYAIDDVSLREIAVPTFTPIKTSNTETANVGDIITYTVTLDNTCDSPLTN
                     VFFRDLIPNGLEFIPGTVTVDGVSVPGVDPNTGFPLPDIGGGTGVEVTFDVVVESIPN
                     PNPTNNIATIDYSYTPVEGGIPNDFSVDSNPVPVEVISADIEVTKLSEPTIVNPGEEL
                     IYTIKVVNNGPFPSENVVLTDDVPASIVNPEYSLDGGVTFQPWTGSLNIGTLEVGETR
                     VIIIRGIVNPSTVGIITNTAVVSSTTADPNLNNNTSTIETEVNLLADILVMKTAEPNS
                     AVPGTLLRYTIQVENLGPANAENVILNDDIPASIINPEYSLDGGASFQPWNGSLNIGT
                     LNSGISLTVLIQGTVSLNSSEYIVNTATVSSTTPDPDLSNNISTIITPVNPQAGISII
                     KVADEDVAVPGEEFVYTIEIFNEGPSNATNVVLTDDIPDVILNPEYSLDGGATFQPWT
                     GSLNIGTVAPGQLIRIIIKGLVSSTATGDITNTAEVSADVPEPVTDSSTVTTPIVPSA
                     DIEVIKTSNMDTAVPGETFSYTITVTNLGPSAAQSIVLTDDIPDVILNPEYSLDGGVT
                     FQPWNGNLSIGTLDAGEIRSIIIRGTVSQTAVGTIINTATISSTTPDPNPDNNTSTDE
                     TDISPLADISVIKGNEPVAIPGGRFIYGIEIANAGPSFAENVTLTDNIPASILNPEYS
                     IDNGVTFQPWNGSLNIGTLDAGEIRNIIIRGTVSQTAIGTIINTATVSSTTPDPNLNN
                     NISTSEAEVSSSADISVVKRSNQTVVVPGDVLDYTIEVRNAGPSTAQNVTLTDNIPAS
                     ILSPEYSIDNGVTFQPWNGSLSIGTLDAGEIRNIIIRGIVSQTAIGTIINTATVSSTT
                     PDPNPDNNTSTSEIDISSSADISVIKLANKTEACVGEQIDFVIVVSNAGPENAQNVTL
                     IDNVSDKLKKAVFSLDRGVSFQPWTGSLNIGTLPAGTLRVIILRGIIKSTCLDRLTNI
                     AEITSTTPDSNLNNNISRVQVEIKQCCCNDCCCNNCSNCCCNDCGCKDCCCNCCKNDF
                     WC"
BASE COUNT         7862 a         2142 c         3238 g         6040 t
ORIGIN      
        1 tagtgagttc tcttttttat tttaaatata aaattataat attgggaggt agtaaaaatg
       61 atagtagtat taaaaatggg agcagataaa aatgaagtta aaaaattaat tgaggctatt
      121 gggagagaag gagtagaagt taatcccata gatggaacag aattaactgt tttaggttta
      181 gttggagata ctagtaaaat agatgccaaa agaatagaag caaataaggt agttgaaaaa
      241 gttatgcatg tggtagagcc ttttaaaaag gccaatagaa aatttcatcc agaaccttca
      301 atcataaatg ttaatggaat ggaaattggt tcaaagaaaa ttgctatgat agctgggcct
      361 tgttctgttg aaacagaaga ccaaatagta tctatagcta aagatgtgaa aaaatcaggt
      421 gcaggatttt tgagaggtgg agcattcaaa ccaagaacat caccatacgc tttccaagga
      481 ttgaaatatg atggattgga tttattaaaa aaagcaaaag aaaaaacagg gcttcctata
      541 gttacagaaa taatgtcaac acaagatata gatatatttg aagaaaatgt agatgtaatt
      601 caagttggag ctagaaacat gcaaaacttt gatttattaa aagaattagg taaaacaaat
      661 aaaacaatac ttttaaaaag aggattatct gctacaattg aagagtggct aatgtcagca
      721 gagtatataa tggctggagg aaatgaaaat gtagttcttt gtgaaagagg tataagaact
      781 tttgaaacat atactagaaa tactttggat ttaagtgcaa ttttagctgt gaagaaactt
      841 agtcatttac cagttatagt tgacccaagt catgcagcag gtaaatcatg gatggttgac
      901 tctttatcta aggcagcaat tgcagttgga gcagatggtc taataataga agttcataat
      961 gacccagcac atgcactttg tgatggaaaa caatcgatta agccaaatga atatgatgaa
     1021 ttgataagtg aattaaagac tatcgcatca gcagttggta gagaaatata atctataaaa
     1081 ggatggttaa acgtggaaga aaaactatta gtaaatttaa aagaaaatag ctacaatata
     1141 tttattaaaa aaaatatact aaagaatata ggagaagaaa taaaaaaaat atattttgga
     1201 aataagattt ttattgtaac tgatgaaaat atagcaaaat tatacttgga taaagtaaaa
     1261 aataatttaa gtgaatctgg atttgaaatt aaatctttaa tattaaaatc tggtgaagaa
     1321 acaaaatcat ttaatactct tcctaaaata tacgatagtt tacttgactt taagttaact
     1381 agaaaagatt tgattattac tttaggagga ggggtaatag gtgatttagg tggatttgca
     1441 gcagcaactt ttttaagagg tataagtttt attcaaattc caacatcttt attagcacaa
     1501 gttgatagtt ctgtaggtgg aaaagttgga gttgaccttg agagaggcaa aaacttagtg
     1561 ggaagctttt accaaccaaa ggctgtgttt atcgacccaa atgtattatt atcacttcca
     1621 gaaaaattct atagagatgg aatggcagaa gttataaaat atggatgtat aaaagacaaa
     1681 acttttttca ataaactttt aagtttaaaa aatagagaag aagtaatgca acatatagaa
     1741 tacattatac ataaatgttg ctttattaaa aaaactgtag ttgaagctga tgaaaaagac
     1801 tttggagata gaatgcttct aaactttggc catacattag gtcatgctat tgagaaatac
     1861 tacaatttta caggttatac ccatggagaa gctgttgcca taggaatgta taagataact
     1921 ttagaaagtg aaaagatagg aattacaaaa aaaggtacat cagaacttat aaaatcaatt
     1981 ttaatgaatt ataatttgcc ttatgagatt gaattaagag ataataaatc tatagtagat
     2041 gctatatctc ttgataaaaa aaatctaggt gatacattaa aaataatact tttaaaagat
     2101 attggagaga gtattatata taatactact tctaaatttt ttcaggaggt aagataatgg
     2161 gaagtctaaa aatatatcca agtaaattat ctggagatgt aaaaatacca ccatcaaaaa
     2221 gtatggcaca tagggcagtt atttgttcat ctctaagcaa tggaaaaagt agaatttcta
     2281 atatagattt ttctgatgat ataatagcta ctataagagc aatgacatca ttaggagcta
     2341 ttatagaaaa gaaagaagat attttagaaa tttcgggaat tttttctaaa gaaggtattt
     2401 taaatagaga gaatcagttg aatcaaccta aattgacaat agattgtaat gaatcaggct
     2461 ctacattgag atttttagta cctatatctt taacatttga tggtgtaaaa aggtttatag
     2521 gtagaggtaa tcttggaaaa agaccacttg atacctatta tgagatattt gacagacaga
     2581 atataaaata tagttacaaa gaaaatcagt tagatttgat tatatcaggt aagcttaaac
     2641 cagatgaatt tagagtaaaa ggaaatataa gttctcagtt tatcacaggt ttactgttta
     2701 tattgcctac gctagaaagt gattcaaaga taataattac tactgagcta gaatctaaag
     2761 gatatttaga tttaactctt tcaacgataa aagattttgg ggtagaaatt ataaacaata
     2821 actataaaga atttattata aaaggaaatc aaacgtataa agcgagagat tataaagtag
     2881 aaggagatta ttctcaagga gcattttatt tatcagcaga tgctatagga gaagatatta
     2941 gcatattaga ccttaaagaa gattctcttc aaggggatag tgaagtagtt gaaattttat
     3001 ctaggatggg aatggaaata ttaagagaag gcaacaaaat aaaaggaata acaaatggtt
     3061 taaatggtac tttgatagat gcatctcaat gcccagatat aatacctgta ttatctgtag
     3121 tagcatcctt aagtataggg aggactacaa taattaatgc tggtaggctt agaattaaag
     3181 aatgtgatag acttcatgca ataaatgttg agttaagtaa acttggagca aatatagagg
     3241 agaaagagga tagtttgata atcgaaggag taagcaagtt aaatggtgga gtagaggtgt
     3301 ggagtcacaa agaccataga attgctatga cacttgcaat tgcttcttgt agatgtgata
     3361 aaccaataat attaaaagat tttgagtgtg tatcaaaatc ttatccacat ttttttaaag
     3421 attttaagat gttaggaggt cgaattgatg agtggaatat ggggaaataa tttaaaagta
     3481 tcaatttttg gagaatctca tggaaatgct ataggtataa atatagatgg tcttccttcg
     3541 gggattgaac ttgaccttga taatattgat aaagaaatga agagaagagc acctggaaaa
     3601 aattctatat ctacttcaag aaatgaaagt gatataccag aaattctaag tggatatttt
     3661 aatggaagaa ctacaggaac gccattatgt gcaatcataa gaaatagtga tactcgttca
     3721 aaagattatg gagagcttaa aaatttaatg agaccaggac atgcagattt cacaggtaat
     3781 gtgagatatt ctggatttaa tgactataga gggggaggtc atttttcagg taggataaca
     3841 gctccattag tattttgtgg ggctatatgt aaacaaattt tatcacaaaa aggaatagag
     3901 ataggagcac acataaaaaa aattaaaaat atagaagata tgagttttga ttatgtaaat
     3961 atttcaaaac aacagttatc aaatttgcaa actttggaac tacctttact tgatttatca
     4021 aaggaagaag ccatgaaaaa tacgattata gatgcaaaaa atcaaggaga ttcagttggt
     4081 ggtataattg agtgtgcagt agtaggtatt aatgtagggc ttggaaatcc attttttgac
     4141 tctgttgaat ctactttatc acatttattg ttttctgttc ctgctgtaaa aggtgtagag
     4201 tttggtttag gttttgaact tgcagatatg tatgggtctc aaagtaatga tgaaatgtat
     4261 tatgaaggaa atcaagttaa gagcaaaaca aataacaatg gaggaattat aggagggatt
     4321 actactggaa tgccaataat tttcaaagtg gcaattaagc caactccatc aattagcaga
     4381 caacaaaaca cagttaatat aaaagataaa aaggacgata ttttatatat taaaggtaga
     4441 catgaccctt gtatagttca aagggctata cctgtaatag aagcagtaac agccattgga
     4501 atttttgatt tgatgaaagg acgataataa tggaggattt aacgagatat agaaatgaga
     4561 ttgacaatat agataaagag cttattcaat tatttgaaaa gagaatgaat acagttcttg
     4621 aaattgccag acataaaatg aaaaataaca ctactatact tcaaaaagat agagaagaaa
     4681 aagtactaag tagagctgta gataatttag ataataaagc atattcacaa gaaacggtac
     4741 agttttttaa ttctataatg gaaattagta gaggattaca aaaaagattg atagataatg
     4801 atggtgagca gaaaatcgag tttagtttag attcatcaaa taagaaattt gatttgtcaa
     4861 atgtaaatag atataagtct ttaaaagatg aattaaataa aaaaaatatc ctagtaggat
     4921 ttccaggaaa atcaggttca tttacagaag aagcactaaa taaattcttc aacaaaaaaa
     4981 tatcaaaaaa acaatttaaa gaatttgaag atgttttcat agcacttaaa aataaagaaa
     5041 taaactatgg aataatcccc atagaaaatt catctacagg agctatctct gaaacttatg
     5101 accttttgag aaagtacggt ttttatatag ttggagaaga atgtataaaa atagaccaaa
     5161 atttaatagg gataaaagac acaaagcttg aagatataaa agaaatatat tctcatccac
     5221 aaggtatagg acaatgtagt aaatttttaa aacaaaatag tacatggaaa ttgataccat
     5281 ttaataacac agcaacaagt gcagaacttg taagaaaact tcaagataaa acaaaagcag
     5341 caattgcaag caaaaaagct gcaagtattt atggattaga aataataagt ccttgtataa
     5401 atgatattgc aaacaactat acaagatttg tagtaatcag taatcaaata cacattgaag
     5461 aagaatcaaa caaaatgagt gtagtatttt ctgttgaaca tgaagcagga aaactttata
     5521 aagtacttgg atactttgct aaaaataata taaatatgac aaaaatagaa tcaagaccta
     5581 tgaaaaatgc ctcatggaga tatttctttt atatagattt tgagtgttct atatacaatg
     5641 ctaaagtgta cgatttatta gaattgatag aacataatac agcatatttt aaatttatgg
     5701 gagtatataa aaataaaact gaatagataa gataaatttt tatttaattt ataattatta
     5761 ggaggtgtaa gtatgaattt tttcggtcta gtaggtgaaa aactctctca cagtgtttca
     5821 cctcaaatcc acaagagagt attcgagata ttgaatattg aaagtgctta taaaaacttt
     5881 gaaatttcaa aagaagatat atctaagcta gacggtgcta taaaattatt aggaatacaa
     5941 ggggtaaatg ttactgtacc atataaggag cgtattatga aatatcttga ttttatatca
     6001 ccagaggcaa aacgtatagg agcagttaat acaattttac ttagagaaaa tatgttatat
     6061 ggttacaata cagattactt tggtcttgat agtatgttta aaatggctaa tattgatgtt
     6121 caaggaaaag tagcagttat attaggaact ggaggtgctt ctaaagctgc tcttacatat
     6181 tttattgatt ctggtataga aaagctttat gtttcaacta gaaaaaagga tgataaaaaa
     6241 ttattaaata gtaaagctat attaatagat tatgaagaac ttaaacatat aaaaggagat
     6301 ataatattaa atgctacacc agtaggtatg taccctaatg taggaatttc accagtgtca
     6361 aaatctatta tacaaaattt tgatatatta atagatttaa tttacaatcc tggagaaaca
     6421 gagtttttaa gaattggtaa tagtatgggt aaaaaaactt gtgatggatt atatatgctg
     6481 gtggggcaag caataaaatc tcaggaaatt tggcaagata ctaaaataga taatagtatt
     6541 ttagatgtta tatataatga actaaaatta gaatttttgt aagggagatt gttatgataa
     6601 ataaaacaaa agaaaaattg atattaatag gtatgccagg tagtggaaaa actacaattg
     6661 gtaaactttt ggccaaagaa tataattgta gtttctgtga tatggatgat tatataattc
     6721 aaatatctca aaaaagtata gcagagttgt tttcagaagg agaagatatc tttaggaact
     6781 atgagactca agcatgtaga gaactttcta taagtgataa aacagtgata tctacaggtg
     6841 gaggtgtaat aaaaaaggat gttaatatgg aaatactaaa agaaacaggt ataataattt
     6901 ttattgatag acctatacaa aagattttgg aagatataaa tattaattca agaccattat
     6961 taaaaaacgg aaaagataga ttgtataatc tttataatga gagaataaat ctttataaaa
     7021 aattttcaga tatagagatt ttaaatgata aatcattaaa taatgctgta tataatatta
     7081 caaatgcagt cagtgaaaat tttaaatttg actttaaaga aaaataatct agggggaaat
     7141 aaaaataatg aatattgtta ttgtaggact aggagttata ggaggctctt ttgctaaagc
     7201 attaaaaaaa gctggatatg aaaatgtatt tggagtagat gtagatttag aaactttaaa
     7261 aaaagcagaa aaagcaaaaa tcataaaaaa aggatgtact acaggtaaag agttatttaa
     7321 aaaagctgat ttaattatat tatctatata tcctagatta gttgtagatt ttctaaataa
     7381 taataaaaac ttttttaaaa aagggactat aattactgat actacaggaa taaaagaaac
     7441 acttatcaat gatgtgttgc aaattattcc agatgatata gattttatat ttggacatcc
     7501 aatggcaggt agggaaaaaa agggtattga ttttgcaagt gaacaagttt ttaatggcgc
     7561 aaattatata attactccaa ctggcagaaa caacataaaa aatttagagt tagttgaaaa
     7621 tttaatttta gagattggat ttaaaagagt aaaaaagtta acttcacaaa aacatgatga
     7681 gattatagct tttacttctc agttacctca tgttatggca gttgctctta taaatagtga
     7741 tgaagaaggt agagatacgg gtaaatttat tggagatagt tatagagatt taactagaat
     7801 tgcaaatatg aatgaagact tatggagtga acttttttta ggaaatagag ataatttact
     7861 aaaagttata gaaaactttg aatcagaagt aaatttagta aaagaagcta tatttaacaa
     7921 tgataaaaat aaattaatag agtattttaa aaaatcatca ataagaagag aagctttaga
     7981 aaaataaata ttaatattta agctatatat agatgggtat aaatataagc gatagtgtat
     8041 ttaattgtat taataaatat ggattcaata taattaaata tgctattgat atatttgtac
     8101 ccttaactat tgttatcttt taaatgataa tgatatttat ttaaatactc tttattaaca
     8161 atttataaaa cttaattgta aaaaatactt attaatagta aaataaagtg aatcaattat
     8221 attataattg ctaaagagag tgaggtgtag ctatttgaaa aaaaatagat taatagcaaa
     8281 gaatatatca atagcattta tagtactatt cttttttagt gtatttacat ttttttatgt
     8341 aggtaatatt aatagagtgt tagaatatga aacaaatgac ataataacag ttacaattgc
     8401 tggatggatt atactttcat ttttattttt aggtattata atttacatat tatattcaaa
     8461 agcaaatagt caaaaaacta tagaaaaagt agcatatacg gattttgtaa caggttattc
     8521 caactggaga aagtttgaat tagatgttac aaatttatta aagaaaacat cacaaaataa
     8581 taaatatgca atggtcatat tcgatattga taaatttaaa gcaattaatg atatatatgg
     8641 ccataaaaag ggaaatttaa tattaaaaga tattgcagat actttaaatg aattgactga
     8701 tatcaatgaa acttttgctc gtgtaagtgc tgataatttc aatatattat taacatataa
     8761 caaaaaagag gatataataa atattatcaa aaagattatg gcaaataatg aacttgtaaa
     8821 cttatctttt ggaatttatg aaatcaaaga taaggattta tctgtaagtg tatatagtga
     8881 tagagcttca cttgcaaaat catcaataaa aaataatagt gatgtaaatt ttgcattttt
     8941 taatgacaaa ttaagagaga aattattatt tgaagataag atagaaaaag aaatggaata
     9001 tgctcttgaa agtgggcaat tcgtaatgta tttacaacca aaatacaata ttaaattaga
     9061 taaattttgt ggaagtgaag ccctagtcag atggcaatat acagaaaaag aggtcatata
     9121 tccaggtgat tttattccta tatttgaaaa aaatggattt attagaaaga ttgatatgta
     9181 catattagaa caagcttgta aagaaatccg gtctttattt gataaaggaa tttcaccttt
     9241 acctatatct gtaaacttct caagagttga tttttttaaa aaagatttta ttgaaaacat
     9301 agtaaatata tgtgatagat ataaaatacc atatagttta atagaaattg aaattactga
     9361 atctagtatg tttggagata ctgatactct atttaatgtt agtagaaacc tacaggatat
     9421 tggctttata gttgcaatgg atgattttgg ctctggatat tcttctgtaa atatgcttaa
     9481 aaatatacca ttaaatgtaa taaaattaga tagaggattt tttgttgatg ataaagatgt
     9541 tgataagagt caaattgtta taaaaagcat agtttctctc attaagcaat taggaataag
     9601 ggttgttgct gaaggaattg aaacaagaag tcaaatagaa atgttaaaaa aagcaaattg
     9661 tgatattgtt caaggatatt atttttcaaa accattacca attaaagaat ttgaaaaatt
     9721 agtctataaa atatagtcag cgagtcttaa atgggaggtg gtgattaagt gataagagca
     9781 aaatcgttaa aaaatgtact gagtattgtt ttaatatttt tatttacaat aatttctttt
     9841 tctgattttg catttaaaac taatgtccag gaagaagaaa atagtaaaat taatttaaga
     9901 gaaatatccc tacaaagttc caatgctata aaaataaaat tagatagttc tctatccttt
     9961 attaaaagtg tggcaaatat ggtttcttat tttaatacta tagataactc aaaaatagtt
    10021 ccattattag ctaatatatc aaaagaatct gactttcaaa gaatctctat tgtatctcct
    10081 gatggaataa gtcataccag tgatggcaaa attatcaatg tgtcaaagta tcagtatttt
    10141 aagaaagcta ttaaaggaga aagtaatata tctgaagttg tgaaatctcc aattgatgga
    10201 aaagatactt ttgttatagc tactcctgta tttaataaga ataacaaaat aattggtgtt
    10261 ttatacggtt cttactacaa tgataaatta gctgaattta tagatataac aagttttaat
    10321 agtgaagggt acatagatat atttgaatct agtggtcaat ttgttttaaa atcttcacat
    10381 acaaacaaac tgattaagtc aagtagtaac atatatgata tatttaaaaa agcttctttt
    10441 gatgatggtt atagctataa aaaaatatat gaagatacaa aaaataacaa gagtggcttt
    10501 acctcatatg aatacaaagg agaaaatcgt tatgctactt atacacccat tggtgtaaat
    10561 gactggtatg taatttctgt gataccacaa tatactgtaa gaagaaacat tgataaaata
    10621 aatcaattag cattttctct tattttcaag gtattcttat tgtttattat gcttataata
    10681 tatattattt ataaaaacaa taaatctcag aaagatatac taaaagctaa caaagaaatc
    10741 tcatctatta caaatagcat tcctggagga gtacaaaagt gtaccctggg tgaaacatgc
    10801 aatattaatt ttttaagtga tggatttata gagttgtttg gttatacaag agaagaaata
    10861 aaaacattgt ttaataatga tttttatagt ttaatacata aagatgatgt tgaaagaata
    10921 aaaaaagaaa tttttaaaca actttacaaa aataaaactg ttgaattaga atataggatt
    10981 ataacaaaaa atggtaatac agtatgggtt ttagataaag gggagcttat aacagaacct
    11041 gatggaaaag aatatttttg ttgtgtaact gtagatatta ctagaacaaa acaattagaa
    11101 caagagatgg aacaaaaaaa tctagaactt gaaatgatat cagaaaatgt tttaggtggt
    11161 ataattataa cagaatttaa tgatgatttt actataaaat acgctaactc tggttatctt
    11221 tcaatgattg gatatacacg tgaacaatta gaaaatgaac ttaaatacaa agcttgtaat
    11281 cttgtttttt atgaggataa aaagaaggct cttgaaagta tacaacatca attaaacaca
    11341 aaaggaatag ctgtatatca acatagaata agaagaagaa atggtaatat tatttgggtt
    11401 tctataaaag gaaggcttat tgttgatgat ggtattgaaa aaggtatttg gattctaaat
    11461 gatataacag atttaaaaaa tgcagaacaa aaacttaaaa taaatgaaga aagatttaga
    11521 attgcattaa agcaaacatc aaacactata tttgagtatg atataaaaac aaagtcactt
    11581 ttaaatacta gtaaagagct tgataaatat aatatttata aaattactaa aaacgttcca
    11641 tattctctag tagaatcagg agttattcat aaagatttta gtgatgattt tataaacatg
    11701 tatgaaaatg taataaatgg agcaaaaaaa gcaagttgtg tagttaagat gaaacttcca
    11761 gatgaaaatt atatatggaa taaagttacc ttgactacta tttttgatga agatggtaat
    11821 cctgtaagag caattggtat acaggaagat ataagcaaac aaaaggaagc agagataaga
    11881 tacaatcaag aaggtaagta tcattcagct atattgtcgg aagcaatgat aacttatgaa
    11941 ataaatgtat caaaggatac ttttatcaaa ggaaatgaaa gttggcaaaa accatttgga
    12001 attaagcctg acaataacta ttctcaaatg gtaaaaacta tagcaaatag tattgtacat
    12061 aaagacaata aagaaacatt tttaaataca tttttatgtg aaaacttatt ggatgcatat
    12121 aaaaataatg tgactgaaat aaaattagaa tatcgaagaa tgaatcaaga aaataaaatg
    12181 atttgggtca tttgtacaat gcacttaata aaagattcta ttacgaacga tataaaagca
    12241 cttgcttatg ttaaagatat tgacaagcaa aaaaatgaag aaattagatt aaaattaaaa
    12301 gctgaaagag atactcttac aggattatat aataaaggta ctacagaaaa attgattaat
    12361 gatttcttga actctgagga agcaagctta ggaatgcatg catttttaat tgttgatata
    12421 gataatttta aatctgtgaa tgataattta ggacatgtat ttggagataa agtattattt
    12481 gaagtttcta aaaacctaaa acctatattt agaaaagatg atatagtagg tagaattggt
    12541 ggagatgaat ttatagtatt cttaaaaaat attcagtctt ttgagaatat caaaaagaaa
    12601 gcagaaaaaa tatgcgatat atttagaaat tcttatacag aaaataaaaa gacatataaa
    12661 atatctggaa cagttggaat ttcatttgta ccagaacatg gaactgtatt tgaagaactt
    12721 tataaaaaag cagacatagc actttattat gcaaagagca aaggaaaaga taagtatgca
    12781 ctttataatg attgtatcta ccaaaatgaa cttgaaaata atataagtga taataatata
    12841 aaattagcag ataaatgtga gaaatccaaa ccagtactta aagaaattct tgattctatt
    12901 gataattata tctatatagt gaatccaaat acttatgaac ttctttttgt caataataag
    12961 gtgtctcgtt tggatttaga gataaaatta ggagaaacct gttataaatc actattaaaa
    13021 tctgatagac catgtaataa ttgccctctt aacggattag aagaaaataa gcattcaaaa
    13081 ttcaaaatag agacaaatac atttggtaaa aatatcagta tagcaagttg gattaattgc
    13141 atagatggag aatacaactg tcttatagag tgtatagatt cttctttata caaaaataaa
    13201 taaaaaagga ctatgaagat atgttaaata gtataacttt gatacttggt ataatattta
    13261 caatttacta tttttatctc aaaatagttt ttggaggaat ttcatttagt gagattttct
    13321 tagttgtagg aattgtacta attatctatc aaatatttaa gaaaaaaatt aaagaaaaga
    13381 aggtttttta tagggtgtta aaaataataa tcagcatttt tttaatagta tttgtagtta
    13441 ctgagagtct aattattttt tatcccaaaa atagtttaga atcaaaaagt gattatctct
    13501 taattttagg agcttctgta aaaaagacta caccaagtac aaccctgaag ggtaggttag
    13561 acactgcatt gaaataccta aaaattaatg ataattgtta tgtggtagta tctggtggta
    13621 aaggaagtgg agaaaaaata actgaggcaa aagctatgaa agattatctt ataaaaaatg
    13681 gtatagataa aaataggata atagaagagg ataaatccac gaatacttat gagaatttta
    13741 aatattcaaa attgaagata gaagaacata gtcaaggaaa actaagcgat ttaaaagtaa
    13801 aaatagtaac aacagatttt catgttctca gaagtaaaat attagcatat agaaatggat
    13861 ataaaaatac gtctttttat gctagtaaat caaaactttc atttgtacca acttactata
    13921 caagagaatt ttttgcatta tggaaaacaa tcatttttga tagataataa ataaaaagac
    13981 tagatataaa ctcatatcta gtcttttcta ttcccttaat tctaatccat tttccaactt
    14041 tacttgttgt agaaatttca acattgggat ttacaagtaa ttgcttataa gaagttttat
    14101 attttacgat tccaaaatat aattttcctt cataatccat tataaatccg aatggtctta
    14161 ctcttggttt attatcttca actgtagcaa aatagaatgt tgagttttct ttaaaaaaat
    14221 tcattatttt ttcatgatta aatcctcttt gtatcttata ctaatataat gaatataaat
    14281 aaaatattca taatactaat ataaatcgat ataaaaacaa ttacaatatt atattgatta
    14341 ttcaaaatta tatataaaat tcagaaaaaa attttagttt acataataaa aataaagtca
    14401 actaaaatta ttgattttag attaaagtac cggattaagc atttaagtag attttaagct
    14461 tgatttgatt agaaaggtac aaactatcac cgaaaaaaat taaacccatt taaaaagcaa
    14521 tataaaagct tgttattttt gagaaaaata gaccctctaa actcaattag attaaaaata
    14581 aaatacagaa aattatatct ctaaatatct taaataatta agtttaaatt ttacgatatt
    14641 ttgtttgatg atttataata taaaagcata ctcttaatct tcaaaattta aaaagagtaa
    14701 aaaataacaa aaaaatcact gacatttcac tgacaaattg taattttgtt attataaata
    14761 cattgaaaat acttgattat tgaaaaatgg cataaaataa tacattttat gccatttgct
    14821 attatttgat agtttttaac ttatgacata agatattttt taacatatac aataaaatat
    14881 aaaaaaattg atattgcaaa taaaaaaaaa tacatattag atgttataga aaaaaagcgc
    14941 acttataggc ttaaaatgtc acataaaaga gttttaaaga ataatatatt atgaacacaa
    15001 attttgtaat cacaaaggag tgataatatg gcaacagtat caggacaaat agtttttgat
    15061 agaaatagaa gtgctaccat tgattctgga gactcaggaa tagccaatat accagttgta
    15121 ttacaagata tagcaactgg agttagactt gtggttctca cagatgcatc aggaaattat
    15181 gtttttacta atgttccaaa tggtaactat agaattgtag aagcttttgg aactacagga
    15241 ggagtaccaa caccaggaaa ttttgcaaca gcgatagtag gtccagttcc aattgcagaa
    15301 atgccaccta ttagttctgt gacaagtcct cctattggtt caacaaactt agatggtaca
    15361 acacctaaca cactattaat aacagtagca ggttcagata taacaaatca aaatatatta
    15421 aatgggcctg tgatttatac acctatagag aatatattgg attcttgcgt atctgtatct
    15481 aatataaacc ttattacaga tgcagataac ggaacattcg gtttttttcc accaggtaca
    15541 ccaagtaata caggacctga aatagaacct tacccaaatg tgacgccaga ttttacgtat
    15601 gttgtaccag acccaactaa gtttacacct ttagatggag aatatacagt acaaaatatt
    15661 atgacaaatg caatgagtaa tgttatagga gcttggtggc gtattgctga ccatactaca
    15721 ggaaatgaaa caggaagaat gatggtggta aatggtttta atcctggagc tgtatttttt
    15781 aaatcaacag tacaagttac acctaacact aattatttat ttagcacttg gattttaaac
    15841 ctttttaagg taacaggata tccaccacca cagctaggtg taagaatatt tgaccaaaat
    15901 aataatatac tatatcaagc aacattagga gctcaaattc cagttaatac aaacgcacca
    15961 gaatggaaag aagtaggtac tgtgattaat tctcaaaata ataatcaact tacagtagaa
    16021 ttttttagtg aaggagaaag cgccattgga aatgactatg ctatagatga tgtttcttta
    16081 agagaaatag ctgttccaac ttttactcca ataaaaacaa gtaacacaga aactgctaat
    16141 gtaggtgata taatcacata tacagttaca ttagataata cttgtgatag ccctttaact
    16201 aatgtatttt ttagggattt aattccaaat ggtttagagt ttatacctgg aactgtaacg
    16261 gttgatggag tatctgtacc aggagtagac cccaatacag gtttcccact tccagatatt
    16321 ggaggaggaa caggggttga agtaactttt gatgttgtgg ttgaaagtat tcctaaccca
    16381 aatcctacta ataatatagc tactatagat tactcctata cacctgtaga aggcggtata
    16441 ccaaatgatt tttcagtaga ttctaatcca gttcctgttg aagtaatctc agcagatatt
    16501 gaagttacaa aattatctga acctactata gtgaatccag gagaggaatt aatatacact
    16561 ataaaagtag taaataatgg accattccca tctgaaaatg tggttttaac agatgatgta
    16621 ccagcttcta ttgtaaatcc agagtattca ttagatggag gagtaacttt tcaaccatgg
    16681 actggaagtt taaatatagg gacattagaa gtaggagaga caagagttat tataattagg
    16741 ggtattgtaa atccatcaac agtaggaatt ataacaaata cagctgtagt atcttcaact
    16801 acagcagacc caaaccttaa taataataca tctacaatag agacagaagt gaatttatta
    16861 gcagatattt tagtaatgaa aacagcagaa cctaattcag ctgttccagg tactttattg
    16921 agatatacta ttcaagtaga aaacttagga ccagcaaatg ctgaaaatgt aatattaaat
    16981 gatgatattc cagcttctat tataaatcca gaatattcat tggatggagg agcaagtttt
    17041 caaccatgga atggaagtct taatatagga actttaaact ctggaatttc attaacagtt
    17101 ttaattcaag gaacagttag tttaaattct tcagaatata tagtaaatac agcaacagtt
    17161 tcttcaacta cacctgaccc agatttaagc aacaatatat ctaccattat tacaccagtt
    17221 aacccacaag caggtatttc tattataaaa gtagctgacg aggatgtagc tgttccagga
    17281 gaagaatttg tatatacaat tgaaattttt aatgaaggac catctaatgc tacgaatgta
    17341 gttttaacag atgatatacc agatgttatt ttaaatccag aatattcatt ggatggagga
    17401 gcaactttcc aaccatggac tggaagtctt aatataggta cagttgcacc agggcaatta
    17461 ataagaatta tcataaaggg attagtaagt tcaactgcta caggagatat tactaataca
    17521 gcagaagtaa gtgcagatgt accagaacca gttacggatt catcaacagt gacaactcct
    17581 atagttccat cagcagatat agaagtaata aaaactagca atatggatac agcagttcca
    17641 ggagaaactt tcagttatac tataacagtt acaaatttag gaccatctgc tgcacaaagt
    17701 atcgttttga cagatgatat accagatgtt attttaaatc cagagtattc attggatgga
    17761 ggagtaactt tccaaccatg gaatggaaat cttagtatag gcactttgga tgctggagaa
    17821 ataagaagta ttataataag aggaacagtg agccagacag cagtaggtac aattataaat
    17881 acagcaacaa taagttcaac tacacctgac ccaaatccag ataataatac ttcaacagat
    17941 gaaacagata taagtccatt agcagatatt tctgtgataa aaggcaacga accagttgct
    18001 ataccagggg gaagatttat ttatggaatt gaaattgcaa atgcaggacc atcttttgca
    18061 gagaacgtaa ctttaacaga taatatacca gcttctattt taaatccaga gtactcaata
    18121 gataatggag tgactttcca accatggaat ggaagcctta atataggtac tttagatgct
    18181 ggagagataa gaaatatcat aataagggga acagtaagtc aaacagcaat aggcacaatt
    18241 ataaatacag caacagtaag ttcaactaca cctgacccaa atctaaataa caatatttca
    18301 acatcagaag cagaggtaag ttcatcagca gatatttctg tagtaaaacg aagcaatcag
    18361 actgttgttg taccaggaga tgtactagac tatacaattg aggtgagaaa tgcaggaccg
    18421 tctactgctc agaacgtaac tttaacagat aatataccag cttctatttt aagtccagaa
    18481 tattcaatag ataatggagt gacttttcaa ccatggaatg gaagtcttag tataggcact
    18541 ttagatgctg gagagataag aaatattata ataaggggaa tagtaagtca aacagcaata
    18601 ggtacaatta taaatacagc aacagtaagt tcaactacac ctgacccaaa tccagataat
    18661 aatacttcaa catcagaaat agatataagt tcatcagcag atatttctgt aataaaatta
    18721 gcaaataaaa cagaagcatg tgtaggagag caaatagatt ttgtaatagt agtatcaaat
    18781 gcaggaccag aaaatgctca aaatgttact ttaatagaca atgtttcaga taagcttaag
    18841 aaagcagtat tttcacttga tagaggtgta agtttccaac catggactgg aagtcttaat
    18901 ataggtacac taccagctgg aactttaaga gtgattatat taagaggaat tataaaatca
    18961 acatgtcttg atagattaac aaatattgca gaaattactt caacaacacc agattcaaac
    19021 cttaacaata atatatcaag agtgcaagta gaaataaaac aatgttgttg taatgattgc
    19081 tgttgtaaca actgtagtaa ttgttgttgc aatgattgtg gttgtaaaga ttgttgctgt
    19141 aattgttgta aaaatgactt ttggtgttga ttttataaaa taattttgta taccttaaat
    19201 taaactgaaa taaaaaataa attcacatat gagtaaaata ttttataaat attaataaat
    19261 tttctatctt tgatatggac ca
//
LOCUS       DAEHWM010000082        19250 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.083, whole genome shotgun sequence.
ACCESSION   DAEHWM010000082 DAEHWM010000000
VERSION     DAEHWM010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 19250)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19250)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19250
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.083"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            335..913
                     /locus_tag="KNP36_002832"
     CDS             335..913
                     /locus_tag="KNP36_002832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_126936537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBF0874691.1"
                     /translation="MGITLSKGQKVDLTKGNPGLKNILVGLGWDTNKYDGGFDFDLDT
                     AAFLTGASGSVTNDGDFVFYNNLKHTSGAVEHLGDNRTGEGDGDDEQIVVDLSKIPGE
                     ISKISFTVTIHDATERRQNFGQVSNSYIRIVDKDTNEELIKYELGEDFSIETAIVVAE
                     IYKHNGEWKFNALGSGFEGGLAALCGNFGINL"
     gene            952..1530
                     /locus_tag="KNP36_002833"
     CDS             952..1530
                     /locus_tag="KNP36_002833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_126936537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBF0874692.1"
                     /translation="MAIVLKKGQKIDLTKGNPGLKNIKLGLGWDTNSFDSGYDYDLDV
                     SVFMVGESQRVEKDEDFIFYNNLKHPSGAVEHLGDNRTGEGDGDDEEILVNLETMPKH
                     IQKIAVTVTIYEAAERRQNFGQVSNSYIRVLNSENDEEILRYDLGEEFSIETAITVCE
                     IYKYNGEWKFSAVGAGFEGGLEALCRNYGLNV"
     gene            1616..2245
                     /locus_tag="KNP36_002834"
     CDS             1616..2245
                     /locus_tag="KNP36_002834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBF0874693.1"
                     /translation="MSINLSKGDKIDLKKSNPGLSNILVGLGWDPVQQSGGGFFKSLF
                     GGGQADIDCDASVFMLNQEGKLSGIKDLIYFGNLKSACKSVLHTGDNLTGEGTGDDEQ
                     ILVNLDKVPSNIHKLLFVVNIYNCVDRKQHFGMIENAYIRVEDQGNKKEIAKYNLSDN
                     YSEKTTLIVGAIYRKDGSWQFKAIGEGTKDAGLKEVMQNLDRIECAYGI"
     gene            2235..4994
                     /locus_tag="KNP36_002835"
     CDS             2235..4994
                     /locus_tag="KNP36_002835"
                     /EC_number="7.2.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-translocating P-type ATPase, PMCA-type"
                     /protein_id="HBF0874694.1"
                     /translation="MEFNNDIKYYNVDKEEVTKDLSVNPEKGLSESEVKTRREKYGLN
                     EFTPKEEGSFWDDLKESLSEPMIVILIIAAVVSAVIGETHDAIGIVGAIAIGIAIGMI
                     TEGRSKKAAEALSKLTENIEVKVLRDGEVHQISKSELVPGDIVYIETGDMVPADGRLI
                     ESINLKIREDMLTGESDDVSKKCDVVVSMEEIESKGAVVVQEPIPAKQINMVFGGTLV
                     AYGRGALVVTSIGDNSEMGKIAQNLSETDEQTPLQIKLGNLGGLIAKVSSAVAGLLFI
                     FMVFQMISKNVLNVDMSGILPFLESIDPVKTAFTVCVALIVAAVPEGLPTMINMTLAI
                     TMQKMAKINALVTKKEACETIGSVSVICSDKTGTLTENRMTVEVAYVDGRYIESSEEE
                     INSYFEENCMINSTADVEHNDGDIKYLGSATECALLLYYKNVDYRQVRKNSNIVAQNP
                     FTSDSKRMTSVIGQDNHHVLLSKGAPEVLLELCSHIQRGKDIVPLTENIKHEILEEIK
                     KLQIKSMRTLGFAYKEISQAEEEAAVTAESDAMNVSAMENNLVFSGFVGIRDPLRKDV
                     IESVNTANKAGVSVKMLTGDNINTARAIGEELGLLKNNMRVVEASYIDTLDDEELKQE
                     IQSISIVARSKPDSKMRIVSALQKSGDVVAVTGDGINDAPALSKADVGIAMGISGTEV
                     SKNAADIILTDDSFSTIVKGIKWGRGIYDNFQRFVQFQLTVNVIAFLVAIISQVMGQE
                     MPFTTIQLLWVNIIMDGPPALALGLEPVRDHVLNRKPVDRKANIISKSMVYTIVLNAF
                     YITAILMLQSTFNFLGVDEAHKGTVMFALFAFSALFNAFNCREFNADSIFPNFTHNKL
                     ALQIIVLTGIAQVIFTQLFQDFFNSVAMDFMTWVKVLCVAASVIVVNEVVKCIIRLVK
                     LKKTA"
     gene            5081..6643
                     /locus_tag="KNP36_002836"
     CDS             5081..6643
                     /locus_tag="KNP36_002836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YceG family protein"
                     /protein_id="HBF0874695.1"
                     /translation="MGDSKVFEKIFSSQSDRGNYTPSKGYLSYFISYIGLEDEVLYNL
                     EIFKTKQNIDSKKDIALFTDVIANPSDFDIINYFKSGLQKYRTSMEDVDINILGFEEI
                     DYKIKQAMDRVLKEEEKEFTNDRVKQNFIVKIMAWIKIYIGALDINKNEAPKVIFYGD
                     IKKHEVYLLLILYLAGFDVLYLNPNSKSNIDILKSERYNIEFEEANIIEEKISFEERV
                     ILGEKIDKSSVKKAFTVGAEASKRISEELLNDAGFIKPWQLQDRKIKNLLLSSTVDEI
                     SIYWNQPLKLRPGFKFNDAIVEAPNFLSKINGIYNDKNEYIKFLDLLRDSESSTFIEF
                     NGDVDRFSKAFTREAFSLSFLLDSKGAIDKNSVLNNKDYSISTLALNQQIMILEKVEE
                     LLEGSMFLNGLSGEDKIKGLFTVLHMDKKFVHMMNNFDYSLINPKLIIYMYKSIVFDK
                     EIVFLMLLLSKIGFDIIILCPGGENNIENVINNQLIDVHRLDKMVYDLKLNSLENDIP
                     LLKKIFGKRRRF"
     gene            6644..7780
                     /locus_tag="KNP36_002837"
     CDS             6644..7780
                     /locus_tag="KNP36_002837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="toxic anion resistance protein"
                     /protein_id="HBF0874696.1"
                     /translation="MGININSFSKDKNSVEVTENLPTAVQEENFDIMEYTNNKKNELR
                     KSKEVEALTSLIEVENPDTILQFGRKASEGVARVSDSLLNTIKLNRNEENSKMLVHLT
                     KIMDKFDLDDFQETKEPNFVQKLFKKANNAIEMMFQKYETLGGEVEKIQIELEQYERD
                     IALSNKQIGAMLNENFEFYNELQKYIVAGEMAIEEMDNEILPFFKQKSETSGDQMDVV
                     NYQELLKVYDMLNQRVYDLRIAENIAIQTIPMLRGMQHNNYGLIRKINSAFVVTLPVF
                     KQCLSQAILLKKQELQAKSLKALDDKTNELLLRNAQNVSTQSAQIARMAGTSSVQIET
                     LEKMYNTIKSGIDETMRIEENNRALIKDNTKRLEELNTTIIYNK"
     gene            7844..8920
                     /locus_tag="KNP36_002838"
     CDS             7844..8920
                     /locus_tag="KNP36_002838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HpcH/HpaI aldolase/citrate lyase family protein"
                     /protein_id="HBF0874697.1"
                     /translation="MKYFDYICKDDLERIFLKEPEDFSAKTEKDVLKYALGAFLYVPA
                     TQYNMIYKSIIGDVKGVRPLAICLEDAVGVNGELEAIENLRLILKNISNESITNKDGI
                     PLIFVRIKDVEQLLRIKEIIIKNSHFITGILIPKANSELIENCIEALDFMNLQDMYVI
                     PIVETKEFIYNEKKELSFTNLYNAILRHKSRILSIRVGITDILGMYGIRRDKNFSIYN
                     NLICSSFILDIITYLQRPELDIPISGGVSEFFDMTNKDIRNKYIEEILLDKYHGLIGK
                     TVIHPMQIQIVQALSTVSYEDFTDALDILDSTDSKYGVSKGVLGERMNETNPHFLWAK
                     KTLILSKIYGVLNKGVDYEELLKF"
     gene            8898..10136
                     /locus_tag="KNP36_002839"
     CDS             8898..10136
                     /locus_tag="KNP36_002839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="HBF0874698.1"
                     /translation="MKNCLNFNCEIDIIDNPLNLELNDFLDVGIRNNSKRRFLFISKK
                     LGKHLACKPSEMDNLGKLMATIYNEKNKEESNGTVIAFAETGTAVGHSFFDYLCGDYE
                     FIHTTREQFDELENLEFLEEHSHATDQNLYFGMLNNFKFGDEIILVDDEITTANTCMN
                     IIRKIQSIYPKKKYTICSILNWVSDENLSKVTRLERELDCKIDFVYLFKGNFKFYIDE
                     DIISNYNDNYSITKLETISSDKVNLVVNHIYVDLEDYIGNKKYVKYTGRFGINRREQF
                     RLKEIVKRESKKITMASKESLKNEKEKILFLGTEEFMYIPMLFAKEKENQYDIYYHST
                     TRSPIINIDKNNYPIKSKFMLKSFYNIDIQNYIYNIDKHNFSKCYLFVELNKSENSYL
                     EFIDIIKKTSIKELTIVCCS"
     gene            10190..11278
                     /locus_tag="KNP36_002840"
     CDS             10190..11278
                     /locus_tag="KNP36_002840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine protease StiP family protein"
                     /protein_id="HBF0874699.1"
                     /translation="MRDFSTYSKDDVIFLLKDISNLIEEEGNKERELKIQNGRHYSEM
                     IPIEYEVSEDYLNLYHEKLRENKDKLAFSIGVMCEKIIKKNGNDVVLVSLARAGTPIG
                     ILAKRYIRSKYNISLPHYTISIIRDKGIDMNAIEYIVKNHPSSKIQFLDGWTGKGTIS
                     KELEKACDELNVKFKKYFDSTLAVLADPAGYSGLYGIREDFLIPSACLNSTVSGLVSR
                     TVLREDLIGKNDFHGAKFYRHLKDKDESMNYIETIEECFKNQFKNISDEVENWESDII
                     TRDGYFDVLNIKEKYNITDINFIKPGVGETTRVLLRRVPYKILVKDLNDKSLDHIFIL
                     AKEKNVEVEQMDLKAYKCCGIIKNMKDI"
     gene            11306..12097
                     /locus_tag="KNP36_002841"
     CDS             11306..12097
                     /locus_tag="KNP36_002841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="HBF0874700.1"
                     /translation="MIVFSDLDRSIIYSNKFLNADSKYTNIEIYREKEISYISLDTIN
                     LIKQIQYYGMFIPTTTRTVEQFKRIEFNKYGIYFPWSITSNGGVILKDNEILKSWSEK
                     IDKLKCDYEPIESMIHKFKDYLNVDGITNFKVAEDTFFYIVVDLSRFNLDSIKEYTNI
                     LESKNWKFYVSGRKIYFIPKEISKENAIKYLTKELGIEYFYAVGDSIMDYGMLNISNK
                     SYVLKHGDINKNEIENSFISSSFNGMSGTEEILSNILDENCLLNI"
     gene            complement(12212..12766)
                     /locus_tag="KNP36_002842"
     CDS             complement(12212..12766)
                     /locus_tag="KNP36_002842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBF0874701.1"
                     /translation="MNIDVGSKIRSLRKSKNISISTLAKNSDLSTGLISQIERNMVVP
                     SIVAMWKISKALDINIGYFFEEIGREDSDIVVKKNNRKKIVTNDSTKFYELLVPNLSG
                     KKIEFILVTLDGHTQKNSEFVTHEGEECGYIIKGKMKITLGNKEYLLEEGDSFYFNST
                     IPHVYENYDDEVCISVWAMTPPSF"
     gene            12962..14164
                     /locus_tag="KNP36_002843"
     CDS             12962..14164
                     /locus_tag="KNP36_002843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 domain-containing protein"
                     /protein_id="HBF0874702.1"
                     /translation="MKSFVSPDNIWVLWAVVTGWAAFSIYLEQKYNWASKVSGAIIAL
                     VGAMLLSNLNIIPVESVVYDQVWGYVVPLAIALLLYQCNIKKIWKESGRLLIIFLVGS
                     VGTVLGAMIGFLALKNVVPDLNIVAAMMTGSYIGGNVNFAAMSGAFDAPGELVSATVV
                     ADNLLMALYFFVLIAIPSIGFFRKHFKHPHVDEMESIGITEGETVAANYWGRKEISLK
                     DIAIAIGSAFIIVAVSVELSTWFKAIIPLSNPFLAMLNTLFGNQYLIITTLTMLFATF
                     MPNFFGDIKGAQELGTFLIYIFFVVVGVPASITLIIQKSPLLLLYCGIMVLINMLVTF
                     IVAKIFKFSLEEAILASNANIGGPTTAAAMAISKGWSKLVGPILIVGTFGYIVGNYFG
                     LLVGNILI"
     gene            14221..15201
                     /locus_tag="KNP36_002844"
     CDS             14221..15201
                     /locus_tag="KNP36_002844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane dipeptidase"
                     /protein_id="HBF0874703.1"
                     /translation="MIFDGHSDTWADVTIRRLNGEKDVFRRIHLDNFKRANIEGAIFV
                     IWIDPPYDKEPEKRVKQIISSIKDEIEDMKDVVNIVKKYSDIDKGISENKINILIGLE
                     GLSHIGRNIDLLDYFYKEVGARHASLTWNEQNELATGCLGDENRGLSEIGKKAVNKME
                     KLGMIVDVSHLNEKSFWDLMSVASKPVIASHSNARSLCDAKRNLTDNQLKEISNTGGL
                     VGINSFRGFTNSNPKKQDLIHLVDHIDYMVNLIGIEHVSFGFDFSDYLGKETIGSFTG
                     NASVPSVDGLESTHTAQNIVVELENRGYKKKDIELISSGNFYRLFKDILK"
     gene            15444..16397
                     /locus_tag="KNP36_002845"
     CDS             15444..16397
                     /locus_tag="KNP36_002845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HBF0874704.1"
                     /translation="MKKRYLVIGIIILSYFSLFIGAEDINIMHIFAKNQHKLMIFIMS
                     RIPRLISILIAGVGMSIAGLIMQQISKNKFVSPTTGATIDAAQFGIVICMLLVPTASI
                     FTKTIIAFVFSLVGTFTFMKIIGKLQFKNIIFVPLVGIMFGNIIGSMTDFIAYKYDLS
                     QNVSSWMQGDFSMILKGNYEILYITIPLIILAYIYANKFTVVGMGMDFATNLGLSYKR
                     IVNIGLIIVALVTVCVVVTAGNIPFIGLIVPNIVSLYMGDNIRASIWYTGLLGAIFVL
                     ICDIFGRIIIYPYEISIGLTVGVIGSILFLYLILRRNVNEA"
     gene            16387..17343
                     /locus_tag="KNP36_002846"
     CDS             16387..17343
                     /locus_tag="KNP36_002846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HBF0874705.1"
                     /translation="MKLSLNQKIYFVSILLFISMALFIIYGIDMNHLEYALSQRIPKI
                     FAMVLGGGCIAFTTVVFQTITNNQILTPSVLGLDSLYVMIQTIIVFIFGSSSSLIINE
                     NYNFIINVAMMIGASLLLYKTLFEKNKNNIFFLILVGMIFGTLFKSATTFIQVMIDPN
                     EFLALQTSIMASLNNINTNVLLIAFIIIIAIIPFIYDEIKYLDVLSLGKEQAINLGVD
                     FDKAVKKMIILIAILVSISTALIGPMTFLGLLLANITREIFKTYKHTYLISGSMLIGM
                     ITLIIGQFFIQHVFKFDTTLSVVINFIGGIYFIQLLLKGANR"
     gene            17340..18095
                     /locus_tag="KNP36_002847"
     CDS             17340..18095
                     /locus_tag="KNP36_002847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0874706.1"
                     /translation="MIEIKNIFKRYKNKNVVDDVSFSIEKGKITSFIGPNGAGKSTVL
                     SIVTRLIGGDGGEVIIEGKSLTNYSNKELAKKIAILKQSNNITLKLTIRELVGFGRFP
                     YSEGNLTKEDENYIDEAIEYMKLTDIQHKYLDELSGGQRQRAYIAMVIAQDTEYILLD
                     EPLNNLDMNHSVQMMKVLRGLCDELDKTIVLVMHDINFASCYSDNIVALKNGKVEKVG
                     RTDEIVNEKVLEDIYEMNFNIKNINGNRICIYF"
     gene            18187..19152
                     /locus_tag="KNP36_002848"
     CDS             18187..19152
                     /locus_tag="KNP36_002848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0874707.1"
                     /translation="MNKKAAIVAAVAIIGLVTVFALGGSKKNESKTSENSNNTMKITH
                     NLGETDVKLNPKKVVVFDYSALDTMDALGVAETLVGLPKASLPASLEKYKDDKYADLG
                     GLKEPDLEGIKSANPDLIIINGRQEDFYEQLSKIAPTISTSKDDKKYLESVKNNIDKI
                     AKIFGVEEKANQEFSKIEKKIETLNKKVTDKNLNALTIMVNEGNLSVFGEESRFSILY
                     NSFGFENKDKNIKESSHGQNITFEYIAKQNPEVMFVIDRGIATGSDVKESSTAKSVLN
                     NDIIKSMDAYKNDNIIYLDSPTWYVNDGGLTSLNKMIDDASKAVN"
BASE COUNT         7603 a         1961 c         3451 g         6235 t
ORIGIN      
        1 ggtagtagtg gcgaagacac cgtccgaagt agcttggctt tgtaaccacc tctgttgtac
       61 tgtttaagta taaataagtg tgttagccac caagaatccc cttgctttag ctatggggag
      121 tgtgtcaaat attaaacata gcttttatac atttaataag gtatgtaaaa tctatgtaaa
      181 aagtaagaaa tataaacatt tttttaatta tattttaaaa atatcaagca agttttcttc
      241 acaaatgaat aaaaaatgtt ataatatgat taaagaaaaa gataaataat tagcaagatt
      301 tgtttagcta aaattaacaa gggagcgata aattatgggt ataacattat caaaaggcca
      361 aaaggttgat ttaactaaag gaaatccagg tcttaaaaat attttagtag gtttaggatg
      421 ggatactaac aagtatgatg gtggatttga ctttgattta gatacagcag catttttaac
      481 aggagcaagt ggaagtgtta ctaatgatgg agattttgta ttttacaaca atttaaaaca
      541 tacatctgga gcagttgagc atctaggaga taacagaact ggcgaaggtg atggagatga
      601 tgaacaaata gttgttgatt tatctaagat tcctggagaa ataagcaaga tttcttttac
      661 tgttacaatt catgatgcaa cagaaagaag acaaaatttt ggacaagtaa gtaattctta
      721 tataagaata gtagataaag acacaaatga agagttaata aagtatgaat taggagaaga
      781 ttttagtata gaaacagcta tagtagtagc tgaaatatat aagcacaatg gagaatggaa
      841 gtttaatgca ctaggttctg gctttgaagg tggtcttgct gcattatgtg gaaactttgg
      901 aataaactta taatttcaac tataacaata aactaaaggg ggatattttc catggctata
      961 gtattaaaaa aaggacaaaa aatcgattta actaagggaa atccaggtct taaaaatata
     1021 aaacttggac taggatggga tacaaattca tttgatagtg gctatgatta tgatttagat
     1081 gtaagtgttt tcatggttgg agaatctcaa agagttgaaa aagatgaaga ttttatattc
     1141 tacaataact taaaacatcc atctggagca gttgaacact taggtgataa tagaactggt
     1201 gaaggtgatg gagatgatga ggaaatatta gtgaatttag agacaatgcc aaagcatata
     1261 caaaagatag ctgtaacagt tacaatatat gaggctgctg aaagaagaca aaattttgga
     1321 caagtaagta actcatatat aagagtatta aattctgaaa atgatgaaga aatattaaga
     1381 tatgacttag gtgaagaatt tagtatagaa actgcaatta cagtatgtga gatatataag
     1441 tataatggag aatggaagtt tagtgcagtt ggagcaggat ttgaaggtgg cttagaagca
     1501 ctttgtagaa actatggctt aaatgtttaa tttaagcaat ataatatatt aaatataaat
     1561 aacctataca aataatgtat aggttatatt atataaaatt ttgtggaggt ttagtatgtc
     1621 gattaattta tcaaaaggtg ataaaataga tttaaaaaaa tctaacccag gactgagtaa
     1681 catacttgta ggtctaggat gggaccctgt gcaacaatct ggtggaggtt tttttaaatc
     1741 gttatttggt ggaggacaag ctgatataga ttgtgatgca tctgtattta tgcttaatca
     1801 agaaggtaaa ttaagtggaa taaaagattt aatttatttt ggaaatctaa aaagtgcctg
     1861 taaatcagtt ttgcatacag gagacaatct aactggtgag ggtacaggtg atgatgaaca
     1921 aatcctagtt aatttggata aagttccatc aaatattcat aaattattgt ttgtagtaaa
     1981 tatatacaat tgtgtagata gaaaacaaca ctttggaatg atagaaaatg cctatataag
     2041 agttgaagac caaggtaata agaaagagat agcaaaatac aatctatctg ataattattc
     2101 tgaaaaaact actcttatag taggagctat atatagaaaa gatggaagtt ggcaatttaa
     2161 agcaattggt gaaggaacaa aagatgcggg tcttaaagaa gtaatgcaaa atttagacag
     2221 gattgagtgt gcatatggaa tttaataatg atatcaaata ttataatgta gataaagaag
     2281 aagttacaaa agacttatct gttaatcctg aaaaaggttt atcagaatca gaagtcaaga
     2341 ctagaagaga aaaatatggt ttgaatgaat ttactccaaa agaagagggt agtttttggg
     2401 atgatttaaa ggaaagttta agtgaaccaa tgatagttat cttgattatt gcagcagtag
     2461 taagtgcagt aattggggaa actcatgatg caatagggat tgtaggtgct atagcaatag
     2521 gtatagcaat aggtatgatt acagaaggtc gttctaagaa agcagcagag gctctttcta
     2581 agttgactga aaacatagaa gtaaaagtat tgagagatgg ggaagtacat caaatttcta
     2641 agagtgaatt ggtaccaggt gatatagtat atattgaaac tggtgacatg gtacctgctg
     2701 atggtagact tatagaaagt ataaacctta aaattagaga agatatgtta acaggagaat
     2761 ctgatgacgt atctaaaaag tgtgatgtag tagtttctat ggaagagata gaatctaaag
     2821 gagcagtagt agtacaggag ccaatacctg caaaacagat aaatatggtg tttggtggca
     2881 cacttgtagc ttatggtaga ggagctctag ttgtaacttc aattggagat aatagtgaaa
     2941 tgggtaaaat tgctcaaaac ttatcagaaa cagatgagca aactccactt cagataaaac
     3001 ttggaaattt aggtggtttg atagccaaag tttctagtgc agtagcagga ttactattta
     3061 tatttatggt tttccaaatg ataagtaaga atgtattaaa tgtagatatg tctggaatat
     3121 taccgttttt agaatcaata gacccagtta aaacagcatt tacagtatgt gttgcgttga
     3181 tagttgcagc agtgccagaa ggtcttccaa ctatgataaa tatgacactt gcaataacaa
     3241 tgcaaaaaat ggctaaaata aatgcattgg ttactaaaaa agaagcttgt gaaacgatag
     3301 gttctgtttc tgtaatatgt tcagataaaa ctggtacatt aactgaaaat agaatgactg
     3361 tagaagttgc atatgttgat ggcagatata ttgaaagttc agaagaggaa ataaatagtt
     3421 attttgaaga aaactgtatg ataaactcta cagctgatgt agagcacaat gatggtgata
     3481 ttaagtattt aggaagtgct actgaatgtg cattgctttt atattacaaa aacgtagatt
     3541 atagacaagt tagaaaaaat tctaatatag tagctcaaaa tccttttact tcagattcaa
     3601 agagaatgac ttctgttata ggtcaagata atcatcatgt actattatca aaaggagcac
     3661 cagaagtctt acttgaatta tgttcacata ttcaaagagg aaaagacata gttccattaa
     3721 ctgaaaatat aaaacatgag attttagaag aaataaagaa attgcaaata aaatcaatga
     3781 gaactttagg gtttgcatat aaagaaatct cacaagctga agaagaagca gcagtaactg
     3841 ctgaaagtga tgctatgaat gtaagtgcaa tggaaaacaa tttagtattt agtggttttg
     3901 ttggtataag agacccactt agaaaagatg ttatagagtc tgtaaataca gcaaataaag
     3961 ctggtgtttc tgtaaaaatg cttacaggag ataatataaa tacggcaaga gctataggtg
     4021 aagagttagg cctattaaaa aataatatga gagtggttga agcttcatat atagatactt
     4081 tagatgatga agaattaaaa caagagatac aaagtatttc aatcgtggca agaagtaaac
     4141 cagatagtaa aatgagaata gtttcagctc tgcaaaagag cggagatgtt gttgcagtaa
     4201 caggtgatgg tataaatgat gctccagcac tttcaaaagc agatgttggt atagcaatgg
     4261 gtatatctgg tacagaggta tctaaaaacg cagcagacat aattttaact gatgatagtt
     4321 ttagtaccat tgtaaaaggt attaaatggg gtagaggaat ttatgataac ttccaaagat
     4381 tcgttcaatt ccaattaact gtaaatgtaa ttgcattttt agtggctata atatctcaag
     4441 ttatgggaca agagatgcca tttactacaa tacaattatt atgggtaaac atcattatgg
     4501 atggaccacc agcactagca ttaggtttag agccagttag ggaccatgtg ttaaatagaa
     4561 aacctgttga tagaaaagcc aatataattt ctaagtcaat ggtgtataca atagtattaa
     4621 atgcatttta tataacagca atactaatgt tacaatctac atttaatttc ttaggagttg
     4681 atgaagcgca taagggaaca gtaatgtttg cgttatttgc ttttagtgca ctgtttaatg
     4741 catttaactg tagagagttt aatgcagata gtatcttccc taattttaca cataacaaat
     4801 tagcactaca aataatagtg ttgacaggaa ttgcacaagt aatatttact cagctattcc
     4861 aagatttctt taactctgta gcaatggatt ttatgacatg ggtaaaagtt ttatgtgtag
     4921 cagcaagtgt aattgtggtt aatgaagttg taaaatgtat aataagactg gtaaaactaa
     4981 aaaagactgc ttaaaacaaa ttttttagaa gaaaacagac tgactcaaaa tatgaatttt
     5041 gggtcagttc tgaataaaca tttaaattgg gaggatagtt atgggtgact caaaggtatt
     5101 tgaaaaaata ttctccagcc aatcagatag aggaaattac actccttcaa agggatatct
     5161 aagttatttt atttcgtata ttggtttaga agatgaagtt ttgtacaatc tcgagatatt
     5221 taagacaaaa caaaatattg atagcaaaaa agatattgct ttatttactg atgttatagc
     5281 aaatcctagt gattttgata ttataaatta ttttaaaagt ggacttcaaa aatatagaac
     5341 tagcatggaa gatgtagata taaatatttt gggatttgaa gagattgatt ataaaataaa
     5401 gcaagcaatg gatagagtgt taaaagaaga ggaaaaagaa tttactaatg atagagttaa
     5461 acaaaatttt atagtgaaaa taatggcatg gataaaaatt tatatcggtg ctttagatat
     5521 aaataaaaat gaagctccaa aagtaatatt ttatggagat ataaaaaaac atgaagttta
     5581 tttactctta atattatact tggcaggttt tgatgtttta tatcttaatc caaattcaaa
     5641 gagtaatata gatattttaa aatcagaaag atacaatata gagtttgaag aagccaacat
     5701 aatagaagaa aaaatttctt ttgaagaaag ggttatttta ggggaaaaaa tagataaaag
     5761 ttctgtaaaa aaagctttta ctgttggggc agaagcatca aagcgtataa gtgaggaatt
     5821 gttaaatgat gcaggattta taaaaccttg gcaactccaa gatagaaaaa taaaaaatct
     5881 acttctaagt tcaactgttg atgaaatatc aatatactgg aatcaaccac ttaaattaag
     5941 accaggattt aagtttaatg atgctattgt agaagctcca aattttcttt ctaagattaa
     6001 tggaatatat aacgataaga atgaatatat taagttttta gatttattaa gagattcgga
     6061 aagttcaaca tttattgaat ttaatggaga tgtagataga ttttcaaaag cttttacaag
     6121 agaagctttt agtttatcct ttttattgga ttcaaaaggt gcaatagata aaaactctgt
     6181 tttaaataat aaagattatt ccatatcaac actagcattg aatcaacaaa ttatgatttt
     6241 agagaaagtg gaagagttgt tagaaggaag tatgtttttg aatggtttaa gtggagaaga
     6301 caagataaaa ggtctattta cagtacttca catggataag aaatttgttc atatgatgaa
     6361 caatttcgat tactcactta taaacccaaa attgattata tacatgtaca agagtattgt
     6421 atttgataaa gaaatagttt ttcttatgct tttacttagt aagattggat ttgatattat
     6481 catattatgt ccaggaggag aaaacaatat agagaatgtt ataaataacc aattgattga
     6541 tgtacacaga ttggataaaa tggtatatga ccttaaatta aattcgcttg aaaatgatat
     6601 acctttactt aaaaaaattt ttggaaagag gagacgattt tagatgggga taaatataaa
     6661 tagtttttca aaagataaga actctgtaga ggttactgaa aatttgccta cagcagttca
     6721 agaagaaaac ttcgatataa tggaatatac aaataataaa aaaaatgaac tgagaaagtc
     6781 taaggaagtt gaggcattga catctcttat agaagtagaa aatccagata cgattttaca
     6841 gtttggtagg aaagcatctg aaggagtagc aagagtttct gatagccttt taaatacaat
     6901 aaaattaaat agaaatgaag aaaattctaa aatgttggtt catttaacta aaataatgga
     6961 caagtttgat ttagacgatt ttcaagaaac taaggaacca aatttcgttc aaaaactttt
     7021 caaaaaagct aataatgcca ttgaaatgat gtttcaaaag tatgaaacat tgggaggaga
     7081 agttgagaaa attcaaattg agcttgaaca atacgaaaga gatatagcac tttctaataa
     7141 gcaaataggt gctatgttaa atgaaaactt tgagttttac aatgaacttc aaaaatatat
     7201 tgttgctgga gaaatggcaa tagaagaaat ggataatgaa atactacctt tctttaaaca
     7261 aaaatcagag actagtggag accaaatgga tgttgtcaat tatcaagaac tattaaaagt
     7321 ttatgatatg ttaaatcaaa gagtctatga tttaaggata gcagaaaata tagctatcca
     7381 aacaatacct atgcttagag gtatgcaaca taataattat ggtttaatta gaaaaataaa
     7441 tagtgcattt gtcgtaactt taccagtatt taaacaatgt ttatctcaag ctatattact
     7501 taaaaagcaa gaattacaag caaaatctct aaaagcactt gatgacaaaa ctaatgaatt
     7561 attgcttaga aatgcacaaa atgtaagtac tcaaagtgca caaatagcta gaatggctgg
     7621 aacaagttct gttcaaatag aaacattgga aaaaatgtac aatactatca agtctggtat
     7681 agatgaaact atgagaatag aagaaaacaa tagagcttta attaaggata atacaaagag
     7741 attggaagaa ttaaatacga ctataattta taataagtag tattatatta agggctaatt
     7801 tgtataaagt tggccctttc tatgtatatg aggaggctag acattgaaat atttcgatta
     7861 tatctgcaaa gatgatttgg agagaatttt tttgaaggag ccagaagatt ttagtgctaa
     7921 gactgaaaaa gatgtgttga aatatgcact gggcgctttt ttatacgttc cagctactca
     7981 atataatatg atttataaga gtattatagg ggatgttaag ggagttagac cattagctat
     8041 ttgtttagaa gatgctgttg gagtaaatgg agagttggag gctatagaaa atcttagatt
     8101 aattttaaaa aatattagca atgaaagtat aactaataaa gatggaatac cactaatttt
     8161 tgtaagaata aaagatgtgg agcaactgtt gagaattaaa gagattataa ttaaaaatag
     8221 tcattttata acaggaatat taattcctaa agcaaattcg gagttaattg aaaattgtat
     8281 agaagcttta gattttatga atcttcaaga tatgtatgtt attccgatag tagagacaaa
     8341 agaatttata tataatgaaa aaaaagaact tagttttact aatttgtaca atgctatttt
     8401 aagacataag tcaagaatat taagcattag agtaggcata actgatatat tagggatgta
     8461 tggtataagg agagataaaa acttttctat atataataat ttgatttgtt cttcatttat
     8521 attagatata atcacatatc ttcaaagacc agagttagat atacctataa gtggtggagt
     8581 atcagaattt tttgatatga cgaataagga tataagaaat aagtatatag aagaaatatt
     8641 attggataaa tatcatggat taattggaaa gaccgtaatt catccaatgc aaattcaaat
     8701 tgtacaagcg ctatctacag tatcatatga agattttact gatgctttgg atatactgga
     8761 tagtacagac agtaagtatg gtgtgagcaa gggtgtatta ggagagagaa tgaatgaaac
     8821 aaatccacat tttttatggg ctaaaaaaac attgattcta tctaaaatat atggtgtatt
     8881 aaataaagga gtagactatg aagaattgct taaattttaa ttgtgagatt gacattattg
     8941 ataatccatt gaatttagaa ctaaatgatt ttttagacgt aggaataaga aataatagca
     9001 aaagacgttt tttgtttatc tcaaagaaac tcggtaaaca tttagcatgt aagccaagtg
     9061 agatggataa tttgggaaaa ttaatggcta caatttataa tgaaaaaaat aaggaagaat
     9121 caaatggtac tgttatagct tttgctgaaa ctggtacagc tgttgggcat agtttttttg
     9181 attacttatg tggagattat gaatttattc atactactag agagcagttt gacgagttag
     9241 aaaatctgga atttttagag gaacattccc atgcaacaga ccagaattta tactttggta
     9301 tgcttaacaa ctttaaattt ggagatgaga taatattggt tgatgatgag attaccacag
     9361 ccaatacatg catgaatata attaggaaaa ttcaaagcat ttatcctaaa aagaaataca
     9421 ctatatgctc aatactcaat tgggtaagtg atgaaaattt aagtaaagtt actcgtttag
     9481 aaagagagct agattgtaag atagattttg tatacttatt taaaggaaac tttaaatttt
     9541 atatagatga agatattatt tcaaattaca acgataatta tagtattact aaattagaga
     9601 ctatttcaag tgataaagta aatttagtag taaatcatat ttatgttgat ttagaagatt
     9661 atattggaaa taagaaatat gtaaaatata caggaagatt tggaattaat agaagagaac
     9721 aatttagatt aaaagaaatc gttaagagag aaagtaaaaa aataactatg gccagtaaag
     9781 aatctttaaa aaatgaaaaa gaaaagattc tatttttagg tactgaagaa tttatgtata
     9841 tacctatgct gtttgcaaaa gaaaaagaaa atcaatatga tatatactat cattcaacaa
     9901 caagaagtcc aattattaat attgataaga ataattatcc tattaaaagt aaatttatgc
     9961 taaagagttt ttataatata gatattcaaa attatattta caatatagat aaacataatt
    10021 tttctaagtg ttatttattt gtagagctga ataaaagtga aaattcttat ctagaattta
    10081 ttgatataat taaaaaaaca agtataaaag aattaactat agtatgttgt agctaaagtg
    10141 ttttaacagg ataaaatata tcacgatttt aagataggag ttgagtcata tgagagattt
    10201 tagcacgtat tctaaagatg atgttatttt tttattaaaa gatatatcaa atttaattga
    10261 agaagaagga aataaagaaa gagaattaaa aatacaaaat ggtagacatt attcagaaat
    10321 gataccaata gagtatgaag ttagtgaaga ttatctgaat ttatatcatg agaaactaag
    10381 agaaaataaa gataaacttg cattttctat aggagttatg tgtgaaaaaa taattaaaaa
    10441 aaatggaaat gatgtagtac tagtttcact tgctagagca ggaacaccta ttggtatttt
    10501 ggcaaaaaga tatataagaa gcaagtataa tataagttta cctcactata caatctctat
    10561 aataagagat aagggaatag atatgaatgc aattgaatat atagtaaaga atcatccgag
    10621 ctcaaaaatt caatttttag atggatggac tggtaaggga actatatcaa aagaacttga
    10681 aaaagcatgt gatgaactta atgttaaatt taaaaaatat tttgactcaa cacttgctgt
    10741 attagctgac cctgctggat attcaggact ttatggaatt agagaagatt tcttaatacc
    10801 aagtgcatgt ttaaattcaa cagtttctgg tttagtaagt agaactgtac taagagagga
    10861 tttaattggt aaaaatgact tccatggagc taagttttat agacatttaa aagataaaga
    10921 tgaatctatg aactatatcg aaactataga agaatgtttt aaaaatcaat ttaagaatat
    10981 atctgatgaa gttgaaaact gggaaagtga cattataaca agagatggat actttgatgt
    11041 tttaaatata aaagaaaagt ataacataac agatattaac tttatcaaac caggtgtagg
    11101 ggaaacgaca agggttttac ttagaagagt tccgtataag attcttgtta aagacttaaa
    11161 tgataaatct ttagaccata tattcatatt agctaaggag aaaaatgttg aagttgaaca
    11221 aatggattta aaagcctata aatgttgtgg aataataaaa aatatgaaag atatttagga
    11281 aatatattag acaggagaat attgaatgat tgttttttca gatttagaca ggagtatcat
    11341 ttactccaat aaatttttaa atgctgatag taaatatact aatatagaaa tttataggga
    11401 aaaagaaata tcttatatat ctttagatac tataaattta ataaagcaaa tacaatatta
    11461 tggtatgttt atacctacaa ctactagaac agtggagcaa tttaagcgta tagaatttaa
    11521 taaatatggg atttattttc cttggagtat aacttcaaat ggaggagtta tacttaaaga
    11581 taatgaaata ttgaaatcat ggagtgaaaa aatagataaa ctaaaatgtg attatgagcc
    11641 cattgaaagt atgattcata aatttaaaga ctatttgaat gtagatggaa taactaattt
    11701 taaagttgca gaagatacat ttttttatat agttgttgat ttatcaagat ttaatttgga
    11761 ttcaatcaaa gaatatacaa atatattgga atcaaaaaat tggaagtttt atgtgagtgg
    11821 cagaaaaata tattttatac caaaagaaat ttcaaaagaa aatgctataa aatacttgac
    11881 taaagaatta ggaatagaat atttttatgc agttggagat tctattatgg actatggtat
    11941 gcttaatatc tcaaataaat cctatgtatt gaagcatggt gatataaata aaaatgaaat
    12001 agaaaattca tttatatcaa gttctttcaa tggaatgagt ggaactgaag agatactatc
    12061 taacatttta gacgagaact gcctacttaa tatataatga ctgatatata aataataaac
    12121 tagaaaaatc tgaaataaat tatagtaaag tttatcatac taatttattt cagattttta
    12181 tcaatttata tttaagtaag aactcaatat gttaaaatga aggtggagtc attgcccaga
    12241 ctgagataca tacctcatca tcataatttt catacacatg tggtatagta ctgttaaaat
    12301 aaaaactatc tccttcctcc aatagatatt ccttatttcc aagtgttatc ttcattttac
    12361 cttttattat atagccacat tcttctcctt cgtgtgtcac aaattcactg tttttttgtg
    12421 tatgaccatc tagtgtaaca agtataaatt ctattttttt cccagataaa ttaggaacaa
    12481 gaagttcata aaattttgta gaatcattag ttactatttt ttttcgatta tttttcttta
    12541 ctactatatc agagtcttct cttccaatct cttcaaaaaa ataacctata tttatatcaa
    12601 gagcttttga tattttccac attgctacaa tagatggaac aaccatatta cgctcaattt
    12661 gacttattaa gcctgtactt aaatctgaat tttttgctaa agtagagata cttatatttt
    12721 tagattttct aagagatcta attttgcttc caacatctat attcattaga tacaaacccc
    12781 ctcagacatg attataacat ataatttata aagattaata aaataaaaaa aaagttttac
    12841 aatacaagta ttttttatgc tatattgaat tttctgaaaa gatgcattat aatagtatta
    12901 atattcaata tattgaatat tgataacgat attttaattt aatgaaatgg aggtaattaa
    12961 gatgaagagt tttgtaagtc ctgataatat ttgggtatta tgggcagttg taactggatg
    13021 ggcagcattt agtatttatt tggaacaaaa gtacaattgg gcatcaaaag tgtcgggagc
    13081 aataatagct cttgtaggag caatgttatt atcaaatcta aatattatac cagtagagtc
    13141 tgttgtatat gaccaagtat ggggatatgt tgttccttta gccatagctt tattgttata
    13201 tcaatgtaac attaaaaaga tatggaaaga aagtggaaga ttgctcatta tatttcttgt
    13261 aggttctgta ggaactgtac ttggagctat gattggattt ttagcattaa aaaatgtagt
    13321 accagattta aatattgttg cagctatgat gacaggttct tatataggtg gaaatgtaaa
    13381 ctttgctgct atgtcagggg cgtttgatgc gccaggagaa ttagtatcag caacagttgt
    13441 agcagataat cttttaatgg cattatattt ctttgtctta atagctatac catcaattgg
    13501 attttttaga aaacatttta aacatccaca tgtagatgaa atggaaagta taggtataac
    13561 tgaaggagaa acagtagcag caaattattg gggaagaaaa gaaatatctt taaaagatat
    13621 agcaatagcc attggtagcg cctttataat tgttgcagta tctgtagaac tatcaacttg
    13681 gtttaaagct ataataccat tatcaaatcc ttttttagca atgttaaata ctttatttgg
    13741 aaatcaatat ctaataataa ctactttgac tatgttgttt gccacattta tgcctaattt
    13801 ctttggtgat ataaaaggag cacaggaatt gggtacattt ttaatatata tattctttgt
    13861 tgtagtaggt gttcctgctt caataacatt aataattcaa aaatcaccat tactactttt
    13921 atactgcgga ataatggtac taataaacat gctagttaca tttatagttg caaaaatatt
    13981 taagtttagt ttagaagaag ctattcttgc atctaatgca aatattggtg gtcctacaac
    14041 agcagcagct atggcaatat caaaaggatg gtctaagcta gtagggccaa tacttatagt
    14101 tggaacattt ggatacatag tcggtaatta ttttggtctt ttagtaggaa atattttgat
    14161 ataattttac gtgaaaaaaa gttgtttatt agaaagattt ttatttaatt ggaggttgtt
    14221 atgattttcg atggacattc agatacttgg gcagatgtaa caataagaag gcttaacggg
    14281 gaaaaagatg tatttagaag aatccatctt gataatttta aaagagcaaa tatagaagga
    14341 gctatttttg taatatggat agacccacca tatgataaag agcctgaaaa aagagttaaa
    14401 caaattataa gttctataaa agatgaaatt gaagatatga aagatgttgt aaacatagta
    14461 aaaaaatatt cagatataga taaaggtata agtgaaaaca aaataaatat tttaattggt
    14521 cttgaaggat taagccatat tggaagaaat atagatttac tagattattt ttataaagaa
    14581 gttggtgcaa gacatgcatc attaacttgg aatgaacaga atgaacttgc tacaggatgt
    14641 ttaggggatg aaaatcgtgg tttaagtgaa ataggcaaaa aagcagtcaa taaaatggaa
    14701 aaattgggca tgatagtaga tgtgtcacat ttaaatgaaa aatcattttg ggatttaatg
    14761 tctgttgcaa gtaagccagt tatagcttct cattctaatg ctaggagttt atgtgatgct
    14821 aaaagaaatc ttacagataa tcaattaaaa gaaatttcaa atacaggtgg attagttgga
    14881 ataaatagtt ttagaggatt tactaatagt aatcctaaga agcaagattt aatacatttg
    14941 gttgaccata tagactatat ggtaaatctt ataggtatag aacatgtatc ttttggtttt
    15001 gattttagtg attacttagg gaaagagact ataggttctt ttactggaaa tgctagtgtg
    15061 ccaagtgtag atggtcttga aagcacacat acagcacaga acatagtagt agagcttgaa
    15121 aatagaggtt ataaaaagaa agatatagag ttaatctcta gtggtaattt ttataggctc
    15181 tttaaagata tactaaaata atataataaa gaacttaaat ttataaaata gtatatttat
    15241 acaaataata tctacatatt taaattggcg ttcataattt attaaatttt aatgttacta
    15301 gaagtttcaa ttctagtaac attttttatg ttaaaaacag atatagatat gtattgacaa
    15361 tgataattat tattgataaa ctataaaagt gaaaatgata ataattttca ttttaattaa
    15421 taaaagattt ttaaggaggg agaatgaaga aaaggtattt agtcatagga ataataattt
    15481 tgtcttattt ttctttattt ataggagctg aagatataaa tataatgcat atatttgcca
    15541 aaaatcagca taaacttatg atatttatca tgagtagaat accaagatta ataagtatat
    15601 tgattgctgg tgtaggaatg agcatagcag gtcttataat gcaacagata agtaagaata
    15661 aatttgtatc acctacaaca ggtgctacaa tagatgcagc acaatttggg atagtaatat
    15721 gtatgctttt agtaccaact gcctctattt ttacaaagac aataatagca tttgtatttt
    15781 ctcttgtagg gacttttacg tttatgaaaa taatagggaa gttacaattt aaaaatataa
    15841 tctttgtacc attagtaggt ataatgtttg gaaatataat agggtctatg acggatttta
    15901 tcgcgtataa atacgatttg agtcaaaatg ttagttcttg gatgcaaggt gacttttcta
    15961 tgatacttaa aggaaattat gagatattat atatcacaat accccttata atattagcat
    16021 atatttatgc aaataaattt actgttgttg gtatgggtat ggattttgcg acaaacttag
    16081 gtcttagtta caaaagaatt gtcaatatag gtctgataat agtagcactt gttacagtat
    16141 gtgtagtcgt tacagctggt aatatccctt ttataggtct aatagttcca aatatcgtat
    16201 ccttgtacat gggtgataat ataagagcaa gcatatggta tactggttta cttggagcga
    16261 tatttgtact tatatgtgat atttttggaa gaattattat ttatccatat gaaatatcta
    16321 tagggcttac agttggagtt ataggaagta tactattcct ttatttaata ttaaggagga
    16381 atgtgaatga agcttagtct caatcaaaaa atttactttg taagtatatt actattcata
    16441 tcaatggcac tttttataat ttatggaata gacatgaatc atttagaata tgcattatca
    16501 caaagaatac caaaaatatt tgctatggta ttaggtggag gatgtatagc atttactact
    16561 gtagtgtttc aaacaattac aaacaatcaa atattaacac caagtgtact aggtttagat
    16621 tcattgtatg taatgattca aactataata gtattcatat ttggttcaag cagtagtctg
    16681 attataaatg aaaattataa ttttattatt aatgtagcta tgatgattgg agcttcattg
    16741 ttattatata agacgttatt tgaaaaaaat aaaaataata ttttcttttt aatcctagta
    16801 ggaatgatat ttggaacctt atttaaaagt gcaacaacat ttattcaggt aatgatagac
    16861 cctaatgaat ttttagcttt acaaactagt ataatggcaa gtttaaacaa tataaacact
    16921 aatgtattgt taatagcatt tataataatt attgccataa taccttttat atatgatgaa
    16981 ataaagtatt tagatgtatt gtcgttaggt aaagaacaag caattaattt aggtgtagat
    17041 tttgataaag cagttaaaaa aatgataata ttaatagcaa ttttagtctc aatatcaaca
    17101 gcacttattg gacctatgac atttttagga cttttacttg ctaatataac aagagaaatt
    17161 tttaaaacat ataagcatac atacttgatt tcgggttcta tgttgatagg gatgattaca
    17221 ttgataatag gtcaattttt tatacaacat gtatttaagt ttgatacaac tttaagtgta
    17281 gtaataaatt ttataggagg aatttatttt attcaattac tattaaaggg ggcaaataga
    17341 tgatagagat aaaaaatata tttaaaagat ataagaataa aaatgttgta gatgatgtct
    17401 cttttagtat agaaaaggga aagataacat cttttatagg accaaatgga gctggaaaaa
    17461 gtacagtact atcaatagtt acaagactta taggaggtga tggtggagaa gtaataatag
    17521 aaggaaaaag cttgactaat tatagcaata aagaattagc aaaaaaaata gctattctta
    17581 aacaatctaa caatataact ttaaagctta caataagaga attagttgga tttggaagat
    17641 ttccatatag tgaaggtaat ctaactaaag aggatgaaaa ttatattgat gaagcaatag
    17701 aatatatgaa gttgactgat atacaacata agtatttaga tgaattgagt ggaggtcaaa
    17761 gacaaagagc ttatatagca atggtaatag ctcaagatac agagtacata ttacttgatg
    17821 aaccactgaa caatttggat atgaaccatt ccgtacagat gatgaaggta cttagaggtc
    17881 tttgtgatga attagataag actatagtat tagtaatgca tgatataaat tttgcatcat
    17941 gttattcaga taatatagtt gcattaaaaa atggaaaagt tgaaaaagta ggtcgtacag
    18001 atgagatagt aaatgaaaaa gttttagaag atatttatga gatgaatttt aacattaaga
    18061 atataaatgg aaatcgaatc tgtatttatt tttaaaatat tgtatatgaa aataaacttg
    18121 ctatatgatt ttttataaag tttttaaatt aaaataaaga ttaataggag agaggaaaat
    18181 attgatatga ataaaaaagc agcaatagta gcagcagtag ctattatagg attagtgaca
    18241 gtgtttgcat taggtggaag taaaaagaat gaatcaaaaa catcagaaaa ttcaaataat
    18301 actatgaaga taactcataa cttgggagaa acagatgtaa aattaaatcc taaaaaagta
    18361 gtggtatttg attattcggc tttagataca atggatgcat taggtgtagc tgagacttta
    18421 gtaggacttc caaaagcgag tttaccagca tccttagaaa aatataagga tgacaagtat
    18481 gcagatttag gaggattaaa agaaccagat ttagaaggta taaagtcggc aaatccagat
    18541 ttaattataa taaatggaag acaagaagat ttttatgagc aattgtcaaa aatagcacca
    18601 acaataagta caagtaaaga tgataagaag tacttagaat ctgttaaaaa taatatagac
    18661 aaaatagcaa aaatatttgg agtagaagaa aaagcaaatc aagaatttag taaaattgaa
    18721 aagaaaatag aaactttgaa taaaaaagta acagataaaa atttaaatgc tttaactata
    18781 atggtaaatg aaggtaattt aagtgtattt ggtgaagaat caagatttag tatattatac
    18841 aatagttttg gatttgaaaa taaagataaa aatataaaag aatcaagtca tggacaaaat
    18901 attacttttg aatatatagc taaacaaaat ccagaagtta tgttcgttat agatagagga
    18961 atagctactg gcagtgatgt aaaagaaagc tcaactgcaa aatctgtttt gaacaatgat
    19021 ataataaaat ctatggatgc atataagaat gataatataa tatatttaga ttcaccaaca
    19081 tggtatgtaa atgatggtgg tctaacatct ttaaataaaa tgatagatga tgcttcaaaa
    19141 gcggtaaatt aataatccga tataaccaaa atgtattttt tataaaatga ttatcaaata
    19201 aactaggagt ttttaagaac tcctagttta ttttttgcat aaaaaagata
//
LOCUS       DAEHWM010000083        18964 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.084, whole genome shotgun sequence.
ACCESSION   DAEHWM010000083 DAEHWM010000000
VERSION     DAEHWM010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18964)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18964)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18964
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.084"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(208..1785)
                     /locus_tag="KNP36_002849"
     CDS             complement(208..1785)
                     /locus_tag="KNP36_002849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp5"
                     /protein_id="HBF0874708.1"
                     /translation="MKAPKTILTILTIALTLSSISIIPSYALTEEKLIGNGRYETAVK
                     ISQKAYSSSPNVVLVNDNSLADALSATPFAKAKGAPILLTESDKLDDRTEKEIKRLGA
                     KDIYLIGGTAVLNKDIENKLKSNGLNVERINGKDRYETSLILANKLKDIKDIKEVAVV
                     NGEKGLSDAVSVGAPAAQNKMPIILSSPKDGVEAFDKFIRDEKVIKAYVIGGTNSVSR
                     AVEKSLPNAERVSGKDRNETNAKVIEKFYTDTNLSNLYVTKDGSKNENQLIDSLAVGV
                     LAAKNESPVVLVGNKLNTKQRDILSTKKLNTITQVGGNGNEEAFDEIKSLQEKTVFEA
                     KTVEELTDMINIASPNDIINFKPKENTVNEAFRMVTNKPITVNIKGDCSKTLTVDMPN
                     GEVNNYATLVNVIVRNIGEGGFNNHDTITILSVRDKNGRVIENTRNSDIDTLMILASA
                     NDTKLINDGYIGKLIDNSSNSDITNNGTIDKKVNQVEDLEAKVDSIEKAIDSISQKVN
                     KIQDILDKLGFLKKFLS"
     gene            complement(2082..4493)
                     /locus_tag="KNP36_002850"
     CDS             complement(2082..4493)
                     /locus_tag="KNP36_002850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBF0874709.1"
                     /translation="MRKYKLKKLSKLLVLLTVCFLIVSTIPVSAEKNKILTGVETAEY
                     SESYLQYLEDVKNGDIAKYNGVIPTPYEMEGTTLKTNVRSSLPASYKSSVSYDPRKLD
                     LTTPAKDQGKLNTCWAFSGMSTLEAYLKLKGYGTYDLSEEHFRWWSTGGIHGWNLTDM
                     TGSSNVTAIGYLTAWAGPKLEKDIPYNFKSEDEGATRPQNMDTAPTQFNVTDVVRISK
                     DKTSVKNAIMQYGAVTSGYAHYSAYLSDDENSYNCNDKSEPLNHSVSIVGWDDNYSKD
                     KFKPSVRPESNGAWLVKSSWGEFNSEKGFFWISYEDKTLLKDTDNYAMKSVSKPDSDK
                     KMYQLEYAGLSKIMSNKVTAANVFDFSRDSEKLDSVMFETDSVGAKYEVYYAPVVNGV
                     PQNNSMTKLASGTVSYSGYINVPTNSYSLPKGKGAIVVVIDNTANPNREKSTLAYETD
                     IDGYYLYEAKANLGESYILQNNKFEDINTYSEFSPCNFVIKAITKTSSGQATSGESLT
                     GADRYETAVKVSQKGWTSSQNAVLVNGDAIVDALTATPFTAAIDSPILLTGKDNLDSK
                     TKAELQRLGTKKVYLIGGENSLSKNVQTQLSNMGISVERISGSDRYKTSISLAQKLNS
                     IKSVSQVAVANGVNGLADAISVGAAAADNNMPIILTNEKSELQGADEFLNSSKITKSY
                     IIGGTATLSSNLESKLSNPTRLAGSNRNETNAKIIDKFYPSSDLKYAFVVKDGSKSQG
                     DLIDGLAVGALGAKTDSPVVLVGNKLDESQKNVLKSKKIETPIRVGGNGNENAFNELN
                     TLLGK"
     gene            4683..5084
                     /locus_tag="KNP36_002851"
     CDS             4683..5084
                     /locus_tag="KNP36_002851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861681.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HBF0874710.1"
                     /translation="MILKKHLETILYLFFGALTVLINIITYLFFTRIINFTFLLSNSL
                     SWSIAVLFSYITNKFFVFKSEKTEFLFLLKEFVSFLSCRLFSGFIEILLMYLMIDLFS
                     LNDILVKIGTNIIVIILNFVFSKVVVFKHRN"
     gene            complement(5149..7266)
                     /locus_tag="KNP36_002852"
     CDS             complement(5149..7266)
                     /locus_tag="KNP36_002852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBF0874711.1"
                     /translation="MQISKKIISLLTAAFLSIVLPSNVVNASNKDSLIGSGRWETAIK
                     ISQNGWLRSDNAVLVNDNSIADALSATPFAKLKDAPILLSGSKELDFRTKSELKRLGV
                     KNVFLVGGSNALGVNVENELKSEKITVERIFGNDRYETSLKLAEKLNNEKDISDIIVV
                     NGEKGLADAVSVGSIAAQNYMPIILSDSNLGVEVANKFIKAQNIKNSYIIGGLNSISN
                     EIEKNLPNSKRISGNNRNETNANVIKEFYKETDLRNAYITKDGMKKQSDLIDSLSVGV
                     LAAKNNSPVVLVGNKIDSIQKDVLNTKIFSTVTQVGGIGNENVYKDILDMQEETKYTV
                     ETIEELDSALKKVDANDIIKFRPDKKISESFKLETEKAIKVDLYGEYSQSITINMPNG
                     ELNNTGDISKTLILKDIKDGTLTNSGYINQMDISDDNGCKIENENNGQIWIVTIFSSA
                     KDVNIRNDGTITKIDNDSSSTNIRNSGKIDTVSGNKEPGISGNKPNTNNTDKDDDSDT
                     AAGLSPKISACSPLENNQIMLTVPQKPKNSNYKIYYRVLSYKPSAMRVGDRININDWD
                     LVEDTEPLKVNAKNGSYIEVVEIDYTRKKVSRWGRAGATDDGFKIVANGIKSTVSVDE
                     NSKVTISVTGYNGNKVYYRIKTTKPEAMNVGDEIDSSWKSTSNSDIILEGNKVNGLYV
                     ELASGENNKVEKWGATDKIEIVS"
     gene            complement(7297..8004)
                     /locus_tag="KNP36_002853"
     CDS             complement(7297..8004)
                     /locus_tag="KNP36_002853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBF0874712.1"
                     /translation="MVDATLFFTPHQDDETLSMGSAIIEHVEKSDTHVILCTDGSKSI
                     IRKVLDDGGSCSYHIKDVHKYSLSESEFSKDRDEEFKDSCEAMGVKESNIHIEDNRAH
                     DGELSKEKAKEIILKYLEEYPEAKVKTVTPFKASGIHEDHRALGEAALELYREGKIKD
                     LRFYVEPYDYKDFKKVNPNVEVWKVLPSQEEKLLSAMNAYKKWNPESGHYAIGYHSVK
                     SHFDDLELNKTQYVHAP"
     gene            complement(8111..9982)
                     /locus_tag="KNP36_002854"
     CDS             complement(8111..9982)
                     /locus_tag="KNP36_002854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp2"
                     /protein_id="HBF0874713.1"
                     /translation="MNKKNLSVIMAAAMISTSVAPVFAAETTQVKKETITKKEATELV
                     SKVRGLMSQKYTGGSQVGQPIYEIKVGETLSKLKIITNIDELEKLVNALGENKELIVT
                     ITDKGHITNSANEVVAEATEKYENSADLSAEANSITEKAKTETNGIYKVADVKASYDS
                     AKDKLVITLRDKTETVTSKTIYVGIGDEKVDLTANPVDSTGTNLDPSAEGFRVNKIDK
                     LGVAGAKNIDDVQLAEITIKNSDLNTVSPQDLYDGYRLTVKGNMVANGTSKSISDISA
                     KDSETGKYKFTIKYTDASGKATELTVESTNEKDLKDAKAALEGNSKVKLIAGDDRYAT
                     AVAIAKQTKYTDNIVIVNSNKLVDGLAATPLAQSKKAPILLASDNEIPKVTLDYIKDI
                     IKKSPSAKIYIVGGESAVSNTAKKQLESVTKNVERLAGDDRHMTSVAVAKAMGSFKDA
                     FVVGAKGEADAMSIAAKAAELKAPIIVNGWNDLSADAIKLMDGKEIGIVGGSNNVSSQ
                     IENQLADIDKDRKVQRVEGETRHDTNAKVIETYYGKLDKLYIAKDGYGNNGMLVDALA
                     AGPLAAGKGPILLAKTDITDSQKNALSKKLNLGAEVTQIGNGVELTVIQKIAKILGW"
     gene            complement(10326..12671)
                     /gene="secA"
                     /locus_tag="KNP36_002855"
     CDS             complement(10326..12671)
                     /gene="secA"
                     /locus_tag="KNP36_002855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HBF0874714.1"
                     /translation="MSVLDTILDKADEQEIRRLNVIVDKIESLEKDIENMSDDELKKM
                     TDLFRDRLKKGETLDSLLPEAFAVAREASKRVLGMRQYRVQLIGGIVIHQGKIAEMKT
                     GEGKTLVEVAPVYLNALTGKGVHVVTVNDYLAQRDKELMQPVYEFLGMSVGVIIADLI
                     PEVRKVQYNCDITYGTNNEFGFDYLKDNMVTKKFDKVQRELNFAIVDEVDSILIDEAR
                     TPLIIAGEGDEDSKLYELANSFIKTIKEEDYELDRKDKTVALKESGIDKAESFFGIKN
                     LTDIENIELYHHINQALRGHKLMEKDVDYVVVNQEVMIVDEFTGRVMDGRRYTDGLHQ
                     AIEAKEGVEIKDESKTMATITFQNFFRLYNKLSGMTGTAKTEEGEFESIYKLNVVQIP
                     TNKPIIRADLHDKVFRTEKEKYQAVVEEVIRIHKTKQPILIGTVSVEKSEMLSGMLKK
                     EGIKHQVLNAKENDKEALIVSKAGKLGSVTIATNMAGRGTDIALGAGDKEEESRVKEL
                     GGLYVIGTERHESRRIDNQLRGRSGRQGDPGTSRFFVSLEDDVIKLYGGKSIEKLMKR
                     PNSNKNNSIESKSLTKAIERAQKGVEGKNFELRKNVLKYDDTINEQRKVIYNERNKVL
                     NDEDIQVDIQNMVKDIIKEAAAEYLTKRKRDYYGYFKHLYNTFMPADTLLIPDLDNKS
                     IEDIIDSTYEISKRVYDLKKMVVGLDKITEMEKIVLLKVVDQYWVEHIDAMEQLKQYV
                     GFKSYAQKDPFKEYAMEGYEMFESLNKNIRETTIQYLYKFN"
     gene            complement(12907..15087)
                     /gene="slpA"
                     /locus_tag="KNP36_002856"
     CDS             complement(12907..15087)
                     /gene="slpA"
                     /locus_tag="KNP36_002856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-layer protein SlpA"
                     /protein_id="HBF0874715.1"
                     /translation="MNKKNLAVVMSAVTVIGSAAPVFAAAEDSFPNGNTTVSSSKYSD
                     IERILKKYVADGVTGITVNFFDKKGNPKGVSISSLEASQISYVKDEIKDLKAGEYAKI
                     SVKITDGTEKKYDDTLLKELDSNAVVTKVGTATTVKIVDQDGNSIENDAKLKLQKYDT
                     TTSAYVDGATKDEVLAATKAAVKTSKFTDKTGNNATGTVAITATYADAVAGAIKLKYD
                     TQAAVAPTLDTAVASLDGTKEIYDFSKPVITVNTTDGTSKLSFEKTGEKVGAVESNVT
                     VIAASDETVTISGDAKEKAEALAKKYVFKDTELEDAYKTVTASDFEKTDNDYYEVVLY
                     PTGKRLNTASTYASSNYKPELPTSDRVDTPAIITLRSTNKNNLKSALDELRTYNNSYS
                     NNSVLAGDDRIETAIEISKDSYNADGGIKGDYVEANEVVLVGSQSIVDGLVASPLAAV
                     KDAPLLLTSKDKLDSSVKSEIKRVMGLDDKTGITSKKTVYIAGGENSVSKEVANELKD
                     MGLKVERLSGDDRYATSLEIADEIGLNHNKVFVVGGTGLADAMSIASVASNKEMPIVV
                     VDGKGKDLSTDAKDFIGSAYVDIIGGKSSVSEDMEDAIDDATGKSPERVSGDDRQDTN
                     AEVIKTYFEKDNSDSVISTGVKNFYVAKDGSTKEDQLVDALAIAAVAGHNEAPIVLAT
                     DSLSSDQSVAISKVTNSDDSKKLTQVGKGIADSVIKRIKDLLEL"
     gene            complement(15380..16978)
                     /locus_tag="KNP36_002857"
     CDS             complement(15380..16978)
                     /locus_tag="KNP36_002857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
                     /protein_id="HBF0874716.1"
                     /translation="MKVNKRVLSIGLTISLIMAGAPNINALSSIEKIQGKDRYETSAL
                     IADKQIYDTVILVNTDNSIVDGLSASGLSGVVKAPIMLVQRDKIPTDVEKRLKDVKNA
                     YVIGTEDTIGKSVENQLKNKGIEVKRIGGEDRIKTSYLIAKEISAIKPVNDGDKVFLV
                     NGYTGEADAMSVSSVAARDGVPVILTDGKSIPFKVDGVQCYSLGSEEIMSNELVSKTN
                     SVRIAGKDRFETNKKVIQRFYKGTKKFYVSQGYKLVDAVAGSPLAKDKPIVLVNDGSD
                     KSVLRGADEVTSLGGMDKKVADQCISSASDKNTMPTITANDVEISVGDKFDNSMLNIV
                     ATDYYGNNLKPNIEGTVDTSKAGTYVLNVSAFDNFGQKCEINVNVKVIINTSTKDPNS
                     YEFKAMVSNEMYNLVNSYRKEKGKKSLRELDSLAGMANAWSKYMDEKKIFAHEIDGKN
                     AAEVFSGFGMRTDENIAYLPMNVKSVYTSKDAKEIAKSVFDLWKKSSKYNDNMLKEEF
                     YSFGFGMYVSNQREVNATMEFLNS"
     gene            complement(17197..18798)
                     /locus_tag="KNP36_002858"
     CDS             complement(17197..18798)
                     /locus_tag="KNP36_002858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp11"
                     /protein_id="HBF0874717.1"
                     /translation="MKMNKKILSLGLAVSLILVNFKSVNASSVVEKIYGKDRYETAAK
                     IADKQTYETVILVNTEKSLADGLSASGLSGATKAPILFTQQNKIPADTNRCLKNIKKA
                     YIIGTEDTISKSVEKELDSKNIEVKRIGGEDRLKTSYLIAKEIATIKKVDKVLLTNAY
                     SGEADAMSVSSVATRDGAPIILTDGKSVPFDVKNIQSYCIGSEEIMSNPLVKNTNSVR
                     IEGTDRFETNKNVIDYFFNSADGFYVSDGYQLVDAIAAAPLTKNSPMVLVNDGSDKTV
                     LEGAKNITSVGEIDEKVIQQCISASKSNGQPPAITVGSTEVYKGEKFDTGKLNIVAKD
                     NTGKVLPIEVDGFIDTNRVGTYILTLKATDEWGKSTGKRVEIKVLDDKSHDYNSPEFK
                     KMVSTEMYNLINSYRKEKGKEPLVVSSKLEGMANAWSKYMMDNKVFEHYIDGKNAPQV
                     FSEFGMRSEENIAYIYIDSKSVQTTQDAKDLAKAIFEVWKKSPEYNANMLSDEFYSTG
                     FGLYILSDGQVHATQEFLNGNEGSL"
BASE COUNT         5583 a         3559 c         2019 g         7803 t
ORIGIN      
        1 agattatttt tctttattct agttttgtca atacttttat ttattttttt gttacattca
       61 attccaatcc ccatgttacc tccccaaagc ttattcaaat atatactaaa ctacatattt
      121 atctataaat ctatttgtat ataaacctgt ttaactacat aactttagaa caattacaac
      181 aaacacttca cttaaatata tatattctta gctaagaaat ttctttagaa atccaagctt
      241 atctagtata tcttgtattt tattgacttt ttgacttata gaatctatag ctttttcaat
      301 tgaatctact ttagcctcta aatcttcaac ctgattaact tttttatcta tagtaccatt
      361 attagttata tcactattag atgaattatc tataagtttt cctatatatc catcattaat
      421 caattttgta tcattagcag aagctaatat catcaacgta tctatatctg aatttctagt
      481 attttctata actctaccat ttttgtcacg aactgacaat atagtgattg tatcatggtt
      541 attaaatcca ccttctccaa tatttctaac tataacattt accaaagtag catagttatt
      601 cacttcacca ttaggcatat ctactgtaag agtctttgaa caatcaccct ttatattcac
      661 agttattggt ttatttgtta ccattctaaa agcttcattt acagtattct cttttggttt
      721 aaagtttata atatcattag gacttgctat atttatcata tcagttaatt cctcaacagt
      781 ttttgcttca aacacagttt tttcttgtag acttttaatt tcatcaaaag cttcttcatt
      841 tccatttcca cctacctgtg ttatagtatt taatttttta gtactaagta tgtccctttg
      901 ttttgtgttt aatttattac caaccaaaac aacaggagac tcattttttg cagccaatac
      961 tccaacagct aacgagtcta ttagttgatt ctcattttta ctaccatcct tagttacata
     1021 taaattactt aaatttgtat cagtgtaaaa cttttctatg accttagcat tagtctcatt
     1081 tctatctttc ccactcactc tttctgcatt aggaagactc ttttctacag ctcttgaaac
     1141 agaatttgta cctccaatta catatgcttt tataactttc tcatccctta taaatttatc
     1201 aaatgcttct actccgtcct taggactaga caaaattata ggcatcttat tttgagctgc
     1261 tggtgcccca acgctaacag catcactcaa tcctttttca ccatttacta cagcaacttc
     1321 cttaatatct tttatatcct taagcttatt agccaaaatc agtgaagttt catatctatc
     1381 cttaccatta attctttcta cattaagtcc attacttttt aacttgttct ctatatcttt
     1441 attaagtaca gcagtacctc ctatcaaata aatatcttta gctcctagac gttttatctc
     1501 tttttcagtc ctatcatcta gcttatcact ttctgtcaaa agtattggtg ctcctttagc
     1561 ctttgcaaat ggtgtagctg aaagtgcatc agctaatgaa ttgtcattaa ctagcactac
     1621 attaggacta gaactgtatg ccttttgact tatctttaca gcagtttcat atctaccatt
     1681 acctattaat ttttcctctg taagtgcata tgatggtatt atagaaatgc tacttaaagt
     1741 aagcgctatt gtcagtattg ttaaaatagt ttttggtgct ttcattatta ttccccctta
     1801 ttttgtttaa aatcttacta tatttatatt ataaaataac tttacactat tttacagttt
     1861 aaaattatta catttttcat caataataag aaaactatct aaaaatatag acaatcctat
     1921 ttttcattat ttaaatgata aaaatataaa acaacaaaaa agagtgcctc atgaactaaa
     1981 aagttcattt tgagacaccc cgttttgtta ttttatattt ataaacttct attgaatatt
     2041 ttttaataat aaaatgtata tccttactat ctttccattc actattttcc taaaagagta
     2101 tttagttcat taaaagcatt ttcatttcca tttccaccaa ctctaatagg agtttctatt
     2161 ttcttagact taagtacatt tttttgactt tcatctaact tatttccaac taaaactact
     2221 ggtgaatcag ttttagcacc taatgctcct actgctagtc catctatcaa gtctccttga
     2281 ctctttgaac catctttaac aacaaaagca tatttcaaat ctgagctagg atagaattta
     2341 tctattatct tagcattagt ttcatttcta ttacttcctg caagtcttgt tggatttgaa
     2401 agcttacttt ctaaatttga tgataaagta gctgttccac caattatata agacttagtt
     2461 attttagatg aatttaaaaa ctcatcagca ccttgcaact cactcttttc attagtaagt
     2521 attattggca tattgttatc agcagctgct gcaccaacac ttattgcatc tgcaagtcca
     2581 tttacaccat ttgccactgc aacttgtgaa acagatttta tactatttaa cttttgagct
     2641 agagatatac tggtcttgta tctatcacta cctgaaattc tttctactga tatacccata
     2701 ttactaagtt gagtttgtac attcttgctt aaagaatttt ctccacctat tagataaact
     2761 tttttagttc ctaatctttg taactctgcc ttagtttttg aatctaagtt atcttttcct
     2821 gtcaaaagaa ttggagagtc aattgctgct gtaaatggtg tagctgttaa agcatccact
     2881 attgcatctc catttactaa tactgcattt tgtgaagaag tccatccttt ttgactaact
     2941 ttaactgctg tttcatatct atctgctcca gttaaagatt ctcctgaagt agcttgtcca
     3001 gaagatgttt ttgttatagc ttttataaca aagttacaag gagaaaattc actatatgta
     3061 tttatatctt caaatttatt gttttgaagt atgtagcttt cacctaagtt tgctttagcc
     3121 tcatatagat agtatccatc tatatcagtt tcatatgcta aagttgattt ttctctatta
     3181 ggatttgctg tgttgtctat aactactact attgctcctt taccttttgg taagctgtaa
     3241 gaattagtag gtacatttat gtatccagaa tatgatactg ttccacttgc aagttttgtc
     3301 attgaattgt tttgaggaac tccatttact actggtgcat aatatacttc atattttgct
     3361 cctacagaat ctgtttcaaa cataacagag tcaagttttt cagaatctct gctaaaatca
     3421 aatacatttg ctgctgttac tttatttgac attatcttgc taagaccagc atattcaagt
     3481 tggtacattt ttttatcgct atctggtttt gatactgatt tcattgcgta gttatctgta
     3541 tcttttaaaa gagttttgtc ttcataagaa atccagaaaa agcctttttc tgagttaaat
     3601 tctccccaac tactttttac taaccatgct ccatttgatt ctggtctaac acttggtttg
     3661 aacttatctt ttgaataatt atcatcccat cctacaattg aaacagaatg atttaaaggt
     3721 tcacttttat cattacaatt atacgaattt tcatcatcac ttaagtaggc tgaatagtgt
     3781 gcatatcctg atgtcactgc accatattgc attattgcat ttttaacaga agttttatct
     3841 ttactaattc ttacaacatc tgttacatta aattgtgtag gtgcagtatc catattttga
     3901 ggcctagttg ctccttcatc ttctgattta aaattatatg gaatgtcttt ttccagctta
     3961 ggtcctgccc aggctgtaag atatccaatt gcagttacat tcgaactacc tgtcatatca
     4021 gttaagttcc atccatgtat tcctccagtt gaccaccatc taaaatgctc ttctgaaaga
     4081 tcataagttc cataaccttt taatttcaaa tatgcttcta gtgttgacat tccagaaaaa
     4141 gcccaacatg tattaagttt tccttggtct tttgctggtg tagttaaatc taattttctt
     4201 ggatcatatg atacacttga tttatatgat gctggaagac tacttcttac attagtttta
     4261 agtgttgttc cttccatttc ataaggagtt ggtattactc cattatattt tgctatatct
     4321 ccatttttta catcttccaa gtattgaaga tatgattcag aatactctgc agtttctact
     4381 ccagtcagaa ttttattttt ttctgctgag acaggtattg ttgacacaat taaaaaacaa
     4441 actgtcaaca acaccagtag ctttgacaat ttttttaatt tatactttct catatttacc
     4501 cccttgtatg tatttaattt ttattatatc agatttctaa atctaggtca tattttattt
     4561 ttataaaaat aggaattata attatacata tataaaatac tattttatac tgcatattta
     4621 ttgattaata tgtggtatac taattacata ataatatata ccaaataatg gaggaaaatt
     4681 ttttgatatt aaaaaaacat ctagaaacaa tattatatct tttttttggt gctttaacag
     4741 ttttaataaa cattattact tacctatttt ttacaagaat tattaatttt acttttttat
     4801 tatcaaactc tctatcttgg tctatagcag ttttattttc atatataaca aacaaatttt
     4861 ttgtattcaa aagtgaaaaa actgagtttt tatttctatt aaaagaattt gtatcttttt
     4921 tatcttgtcg tttattttct ggttttatag aaatattact tatgtattta atgattgatt
     4981 tattttcttt aaatgatatc ttagtaaaaa taggcactaa tataattgtg ataattttaa
     5041 acttcgtctt cagcaaggta gtagttttta agcatagaaa ttaacattat tatatttatc
     5101 tttatgcaga ataaggagtt gcctaaaaaa aacaactcct tattagcttt aagaaacaat
     5161 ttctatttta tctgttgctc cccatttttc aactttatta ttttctcctg atgctaattc
     5221 tacataaagt ccatttacct tatttccttc taaaattata tcactattag aagtactttt
     5281 ccaactggag tctatttcat ctcctacatt catagcttct ggttttgtag tctttattct
     5341 atagtaaact ttattaccat tgtatccagt tacactaata gttactttag aattttcatc
     5401 aacagaaaca gttgatttta ttccatttgc tactatttta aaaccatcat ctgtcgcacc
     5461 agctcttccc catcttgaaa ctttctttct tgtataatca atttcaacaa cttctatata
     5521 tgatccattc ttagcattta cttttaatgg ttccgtatct tcaaccaagt cccaatcatt
     5581 tatgttaatt ctatcaccaa ccctcatagc tgatggttta tatgacaaaa ctctataata
     5641 aattttataa tttgaatttt taggtttctg aggtacagtt aacataattt gattattctc
     5701 aagaggagaa catgcactta tctttggaga taatcctgct gctgtatcac tatcatcatc
     5761 tttatctgta ttattagtgt taggtttatt gccacttatt cctggttctt tatttccact
     5821 aacagtatca atctttcccg aatttcttat attagtactt gaagaatcat tatctatctt
     5881 tgttatagtt ccatcatttc ttatatttac atcttttgca gaactaaata ttgttacaat
     5941 ccatatttgt ccattatttt cattttcaat cttgcaacca ttatcatcag aaatgtccat
     6001 ttgatttata tatcctgaat tagttaaagt tccatctttt atatctttaa gtatcaatgt
     6061 tttacttata tcacctgtat tattcaactc tccatttggc atatttatag ttattgactg
     6121 actatattct ccatataaat caacctttat agctttttca gtctctaatt taaaagattc
     6181 acttattttt ttatcaggtc taaactttat aatatcatta gcatccactt tctttaaagc
     6241 agaatccaat tcttcaattg tttcaactgt atatttagtt tcttcttgca tatccaatat
     6301 atctttatag acattttcat ttcctattcc accaacctga gtaactgtac taaatatctt
     6361 agtatttagt acatctttct gaatagaatc aattttattt cctactaata ccactggaga
     6421 attgtttttt gcagccaaca ctccaactga tagtgaatct attaaatcac tttgtttttt
     6481 cattccatcc ttggttatat atgcatttct taaatctgtt tctttataaa attcttttat
     6541 aacattagca tttgtttcat ttctattatt tcctgatatc ctcttagaat ttggtaaatt
     6601 tttttctatt tcattagaaa tggaatttaa tcctccaata atataagaat tttttatatt
     6661 ttgggctttt ataaatttat tagctacttc aactccaagg tttgaatctg aaagtataat
     6721 tggcatgtaa ttttgagctg ctattgaacc aacacttaca gcatctgcta atcccttttc
     6781 tccatttact acaattatat cagaaatatc tttttcatta ttcaattttt cagccaattt
     6841 taaggatgtt tcatatctat cattcccaaa aattctttca actgttattt tctctgattt
     6901 taattcattt tctacattta cacctagtgc atttgaacct cctactaaaa atacattttt
     6961 tactccaagc ctttttagtt ctgattttgt cctaaaatcc aattctttac ttccagatag
     7021 taaaataggt gcatctttca atttagcaaa tggagttgca gataatgcat ctgctattga
     7081 gttatcattc actaatacag cattatcaga tcttaaccaa ccgttttggc ttatttttat
     7141 tgctgtttcc catctacctg aacctattaa actgtcttta ttagatgcat ttaccacatt
     7201 actaggtaaa acaattgata aaaatgctgc tgttaataaa gatattattt tttttgatat
     7261 ttgcattaat tatctcctcc taatttaaat ataattttat ggagcatgta catactgtgt
     7321 tttatttaat tctaaatcat caaaatgaga ttttactgaa tggtatccta tagcataatg
     7381 tccactttca ggattccatt tcttatatgc attcatcgca cttaataact tctcctcttg
     7441 actaggtaat accttccaga cttctacatt tggattaact tttttaaaat ccttatagtc
     7501 atatggttct acataaaatc ttaaatcttt tatttttcct tctctatata actctagtgc
     7561 agcttctcct aatgctctat gatcttcatg tattccacta gctttaaacg gagtaacagt
     7621 ttttactttt gcttctggat attcttctaa gtatttaagt attatttcct ttgccttttc
     7681 tttgcttaac tcaccatcat gagctctatt atcttctata tgtatattac tttcttttac
     7741 acccattgct tcacagctat ccttaaattc ttcatctcta tcttttgaaa attcactttc
     7801 tgataaagag tatttatgaa catctttaat atgataagaa catgaccctc catcatccaa
     7861 aacttttctt attatagatt tactaccatc tgtgcacaat atgacatgtg tatcactttt
     7921 ttcaacatgt tcaattatag cacttcccat acttaaggtt tcatcatctt gatgtggtgt
     7981 aaaaaacaaa gttgcatcta ccactactac atcctcctac tttataaaat gttataattt
     8041 acaataaata gcataattat agaaaaagat tcctgtatta attaaggaat cttctccaca
     8101 gtataagtta ttaccaacct agtattttag ctatcttttg tattactgtc aattcaactc
     8161 cattacctat ttgagttact tctgcaccaa gatttaattt tttactaagt gcattctttt
     8221 gtgagtctgt tatatcagtt ttagctagaa gtattggacc tttacctgct gctagaggtc
     8281 ctgctgccaa tgcatctact agcataccat tatttccata tccatctttt gctatatata
     8341 gtttatctaa tttgccataa tatgtttcta taactttagc attagtatcg tgtcttgttt
     8401 ctccttcaac tctttgaact tttctatctt tatcaatatc tgcaagttga ttttcaattt
     8461 ggctagatac attattagag ccaccaacta tgccaatctc ttttccatcc atcaatttga
     8521 tagcatctgc tgatagatca ttccaaccat ttactattat aggagcctta agttcagcag
     8581 ctttagcagc tatactcata gcatcagcct ccccttttgc gcctactaca aatgcatctt
     8641 taaaagaccc catagctttt gctactgcta cagaagtcat atgtctatca tctccagcta
     8701 gtctttcaac attcttagtt actgattcta attgcttttt agctgtattt gatactgctg
     8761 attctccacc tactatatat attttagctg atgggctttt cttaattata tcttttatat
     8821 aatctaaagt tacttttggt atttcattat cagatgctaa taatataggt gcttttttag
     8881 attgagcaag tggtgtagct gctaatccgt caactagttt atttgaatta actataacta
     8941 tattgtcagt atattttgtt tgttttgcta tagccactgc agttgcatat ctatcatctc
     9001 cagctatcaa tttaaccttt gaattacctt ctaatgcagc tttggcatct tttaaatctt
     9061 tttcattggt actttctaca gtaagctctg ttgcttttcc agatgcatca gtatacttaa
     9121 tagtaaattt atattttcct gtttctgaat cttttgctga aatatcacta attgactttg
     9181 atgtaccatt tgctaccata ttacctttaa cagtcaatct atatccatca tataaatctt
     9241 gtggtgaaac tgtatttagg tcactatttt ttatagttat ttcggccaat tggacatcat
     9301 caatattttt agctcctgct acacctagtt tatcgatttt atttactcta aatccttctg
     9361 cagaagggtc taaatttgtt ccagttgaat caactggatt tgctgttaaa tcaacttttt
     9421 catcaccaat acctacatat atagttttag aagttactgt ttctgtttta tctcttaaag
     9481 ttataactaa cttatcttta gcactatcat atgaagcttt tacatctgca actttataaa
     9541 ttccattggt ttcagtttta gctttttctg ttatagaatt agcctcagcg gaaaggtctg
     9601 ctgaattttc atatttttca gttgcttctg caactacttc atttgcacta tttgttatat
     9661 gtcctttatc tgttatagtt acaataagtt ctttattttc tcccaaagca tttactaatt
     9721 tctctaattc atctatatta gttattattt ttaattttga taaagtctca ccaactttta
     9781 tttcatatat tggttgtcca acttgagaac ctcctgtata cttttgagac attaaacctc
     9841 taactttcga aactaattct gtagcctctt tcttagttat tgtttctttt tttacctgtg
     9901 tagtttctgc agcaaaaact ggagctactg atgtacttat cattgcagca gccataatta
     9961 cagaaagatt ttttttattc atggtatttt ccccctaaaa aattcaaatt tttattattt
    10021 tttccttatt taccaattat aatatatatt tgatattatt tcaataaatg agacttattg
    10081 taataattaa ccaaaagata taaacttttt cttatatttt atttttttaa tatttacgta
    10141 tacaaaaaag taacaaaatt gtaatttttt ttaataatcc agtttataac taatagactt
    10201 ttcatcttct ttatagtata atattaaatg gaagaaagaa atttcaagca tctctttttt
    10261 ccgtatttct cacatagaaa aagaggctga ttatcagcct ctttttccta tacagtttaa
    10321 atttcttaat taaatttata taaatactgt atagtcgtct ctcttatatt tttatttaat
    10381 gattcaaaca tctcataacc ttccatagca tattctttga aaggatcttt ttgagcatat
    10441 gatttaaatc ctacatattg ttttaattgc tccatagcat ctatatgttc tacccaatat
    10501 tgatcaacta cttttaaaag aacaattttt tccatttcgg ttattttgtc aaggcctact
    10561 accatctttt ttaaatcata aactcttttt gatatttcat aagtactatc aattatatcc
    10621 tcaatacttt tattatctaa gtcaggtatt agtaaggtat cagctggcat aaatgtatta
    10681 taaagatgct taaaatatcc atagtaatcc ctctttcttt ttgttaaata ttcagcagca
    10741 gcttctttta ttatatcttt aaccatgttt tgaatatcta cttgtatatc ttcatcattt
    10801 agaactttat ttctttcgtt atagattact tttctttgtt catttatagt atcatcatat
    10861 ttaagaacat ttttccttaa ttcaaaattt ttaccttcca cccctttttg agctctctct
    10921 attgcctttg taagagattt actttcaata gaattatttt tatttgaatt tggtcgtttc
    10981 attagtttct ctatactttt tccaccatac aatttgatta catcatcttc aagactaaca
    11041 aaaaaccttg atgttcctgg atcaccttga cgtccagaac gccctctaag ctgattatcg
    11101 attcttctag attcatgtct ctcagttcct attacataaa gtcctcctaa ttcctttact
    11161 ctactttctt cttctttatc acctgctcct aaagcaatat ctgttcctct acctgccata
    11221 ttagttgcaa tagttactga acccaactta ccagcctttg acactatcaa tgcttcttta
    11281 tcattttcct tagcatttag aacttgatgt tttattcctt ctttcttaag cataccagat
    11341 aacatttctg atttctcaac agaaacagta ccaataagaa ttggctgttt tgttttatgt
    11401 atccttatta cttcttctac aacagcttga tacttttctt tctctgttct aaacacttta
    11461 tcatgaagat ctgctcttat aattggtttg ttagtaggaa tttgtacaac atttaattta
    11521 taaattgatt caaattctcc ttcttcagtt ttagcagtcc ctgtcatacc agaaagttta
    11581 ttatataatc taaagaaatt ctggaatgta attgtagcca tagttttaga ttcatctttt
    11641 atttctaccc cttcttttgc ttctatagct tggtgtaagc catctgtata tcttcttcca
    11701 tccattactc ttcctgtaaa ttcatcaact atcattactt cttgattaac aacaacataa
    11761 tcaacatctt tttccataag tttgtgaccc ctaagagcct gatttatatg atgatataat
    11821 tctatatttt ctatatctgt aagattttta atcccaaaaa atgattctgc cttatcaata
    11881 ccactttcct ttagagctac ggtcttatct tttctatcta attcataatc ttcttctttt
    11941 attgttttta taaatgaatt tgctaattca taaagttttg aatcttcatc accctctcca
    12001 gcaattataa gtggagttct agcttcatct ataagaattg agtcaacctc atcaactatg
    12061 gcaaaattca actctctttg tactttatca aactttttag ttaccatatt atcttttaaa
    12121 taatcaaatc caaattcatt atttgtacca taagtaatat cacaattgta ttgaactttt
    12181 ctaacttcag gtataagatc tgcaataatt actcctacag acatacctaa aaactcatac
    12241 actggttgca ttagctcttt atcacgttgt gctagatagt catttactgt aacaacatgc
    12301 acacctttac ctgttaaagc atttagataa acaggtgcaa cttctaccaa agttttacct
    12361 tcaccagttt tcatttctgc tatttttcct tgatgaatta caatgcctcc aattaattga
    12421 accctatatt gacgcattcc taaaactctt tttgaagctt ctcttgccac tgcaaatgct
    12481 tctggtaata aactatctaa agtttctcct ttttttaatc tatctctaaa taggtctgtc
    12541 atttttttta attcgtcatc agacatattt tctatatctt tttctaaaga ttctatttta
    12601 tcaactatca cattaagcct tcttatttcc tgctcatctg ctttatccaa tattgtatcc
    12661 aaaactgaca tatttaattt acctcctttt ttatcataca attactatta taccttaaaa
    12721 ttatagaata gtagacaatt atttttattt atagtataat aatcatactt aaataaatta
    12781 catctttaat tatttaggta tttctcacaa aaaaaggaac tatttttagt tcctttttta
    12841 atttcttttt ataaaaaaga gaacttcttc aaagaagttc cctcttattt atagtttaat
    12901 tttatcttat aattctaata aatcttttat tctcttaata actgaatctg ctattccttt
    12961 accaacttga gtcaatttct tagaatcatc agaatttgta actttactta ttgctactga
    13021 ttggtcagaa gataaactat cagttgctaa aactattgga gcttcattgt gacctgctac
    13081 tgctgctatt gctaacgcat ctactaattg atcttctttt gtagaaccat ctttagcaac
    13141 atagaagttt ttaacacctg tgctaattac actgtcacta ttatcttttt caaaataagt
    13201 ttttataact tctgcattag tatcttgtct atcatctcca ctaactcttt ctggactctt
    13261 acctgtagca tcatctatag catcttccat gtcttcagaa acactagatt ttccacctat
    13321 tatatctaca taagcacttc ctataaagtc ttttgcatca gttgataaat cttttccttt
    13381 tccatcaact actactattg gcatttcttt attagaagca actgatgcta tactcattgc
    13441 atctgctaat ccagtaccac caactacaaa tactttatta tggtttaaac ctatttcatc
    13501 agcaatttct aaagatgtag catatctatc atcaccagat aatctttcaa cttttaatcc
    13561 catatctttt aattcatttg ctacttcttt agatacagaa ttttccccac cagctatata
    13621 aacagtcttt ttagatgtta taccagtttt atcatctaat cccattactc tctttatttc
    13681 agattttact gatgaatcta acttatcttt tgaagttaat aataatggag catctttaac
    13741 agcagctaaa ggtgaagcta ctagaccatc tactattgat tgtgatccta ctaatactac
    13801 ctcattagct tctacataat ctcctttaat tcctccatct gcattataag agtctttact
    13861 tatttctatt gcagtctcta ttctatcatc accagctaat acagaattat ttgaataaga
    13921 attattataa gttcttaatt catctaaagc tgattttaag ttattcttat tagtagatct
    13981 taatgttatt atagcaggag tatctactct atcacttgta ggtaattctg gcttatagtt
    14041 agatgatgca tatgttgaag ctgtatttaa tcttttacct gttggataaa gaactacctc
    14101 ataataatca ttgtcagttt tttcaaaatc acttgctgtt actgtcttat atgcatcttc
    14161 taattcagta tctttaaata catatttttt agctaaagct tctgcttttt cttttgcatc
    14221 tccagatatt gtaactgttt catctgatgc tgctataact gttacatttg attcaactgc
    14281 tccaactttt tctccagttt tttcaaaact taattttgat gtaccatcag tagtattaac
    14341 cgttataact ggtttactaa aatcatatat ctctttagta ccatcaagag atgctactgc
    14401 tgtatctaaa gtaggtgcta ctgctgcttg tgtatcatat tttaatttaa ttgcaccagc
    14461 tactgcatca gcatatgttg ctgtaatagc tactgttcct gtagcattat taccagtctt
    14521 atcagtaaat tttgaagttt tgactgctgc ctttgtagct gctaaaactt catctttagt
    14581 agctccatct acataagctg acgtagttgt atcatatttt tgtaacttta atttagcatc
    14641 attttctatt gaatttccat cttgatctac aatcttaact gttgttgcag taccaacttt
    14701 agtaactaca gcattactat caagttcctt taataatgta tcatcatatt ttttttctgt
    14761 tccatctgta atttttacag atatttttgc atattctcca gcttttaaat ctttaatttc
    14821 atctttaaca taacttattt gacttgcttc taaacttgat atagataccc cttttggatt
    14881 tccttttttg tcaaaaaagt taactgttat gcctgttaca ccatctgcaa catatttttt
    14941 aagtattctt tctatatcac tatacttact actagataca gtggtatttc catttggaaa
    15001 actatcctct gctgcagcga aaactggtgc tgctgatccg attactgtaa cggcagacat
    15061 tacaactgcc aaatttttct tattcattcc ttaaattcct cccaacatta tattaattac
    15121 atctctttaa ttatgtacat taaaattcca tgttcatata aaccaaatat ttctcacact
    15181 cttatgatag actatataaa atagaatttc aataatttat gcaaaattaa tagaattttc
    15241 tttcaacatt tttccccttt tttttgctat ttcatatttt ttaaattaaa ttttcaattt
    15301 taattttatt aatacattta tttatctgat ttaatcaata tatattaata ttttctacca
    15361 taaaatatta atatatactc taactattta aaaattccat tgtagcatta acttctcttt
    15421 gattagaaac atacattcca aagccaaaac tataaaactc ttcctttaac atattatcat
    15481 tatacttaga agacttcttc cataaatcaa atacagactt agcaatctct tttgcatctt
    15541 tagatgtata tacagactta acattcatag gtaaatatgc aatattttca tcagttctca
    15601 ttccaaagcc agaaaatact tcagctgcat ttttcccatc tatttcatga gcaaatatct
    15661 tcttctcatc catatactta gaccatgcat ttgccattcc agctaaagaa tctaattctc
    15721 ttaaactttt cttacctttt tcttttctat atgaattaac tagattatac atttcattag
    15781 ataccatagc cttaaactca taactattag ggtcttttgt acttgtgttt ataattactt
    15841 tgacatttac attaatctca cacttttgcc caaaattatc aaaagcactt acatttaaaa
    15901 catacgttcc tgccttactg gtatccacag ttccctcaat attaggcttc aaattatttc
    15961 cataataatc agtggcaact atattcaaca tactattatc aaacttatcc cctacagaaa
    16021 tctctacatc attagcagtg attgtaggca ttgtattttt atcagatgca gaactaatac
    16081 attggtcagc aaccttctta tccattccac ctaaagaagt aacttcatca gcacctctaa
    16141 gcacactctt atcacttcca tcattaacaa gtactatagg tttgtcctta gccaacggag
    16201 aaccagccac agcatcaact aacttatacc cttgagaaac ataaaacttc tttgttcctt
    16261 tataaaagcg ttgtataacc ttcttattag tttcaaatct atctttacca gcaatcctaa
    16321 cagaattagt cttactcaca agttcattac tcattatctc ctctgaccca agagaataac
    16381 attgaacgcc atcaacctta aatggtatac tctttccatc agtaagtata acaggaactc
    16441 catctctagc agctacagaa gatacactca ttgcatcagc ctcacctgtg tatccattta
    16501 caagaaaaac cttatcacca tcatttactg gtttaatagc tgaaatctcc ttagctataa
    16561 gatagctagt ctttattcta tcttccccac caattctttt aacttcaatc cctttattct
    16621 taagttgatt ttctacagat ttacctattg tatcctctgt acctataaca taagcattct
    16681 taacatcctt tagtcttttt tcaacatctg ttggtatctt atctctttgc actaacatta
    16741 taggagcttt tacaactcca gataatccac ttgcacttaa tccatctact atagaattat
    16801 cagtatttac taatatgact gtatcatata tttgtttatc tgctatcaat gcagaagtct
    16861 catatctatc tttcccttgt atcttttcta tactcgaaag tgcattgata tttggtgctc
    16921 ctgccattat taatgatatt gtcaatccta ttgataatac tctcttattt accttcatcg
    16981 aactcctcct actaattttt ttatataatt cagctaatca taaattacac cctcagtagt
    17041 gattccctca aaatttataa actactaaaa caaaaaacac ctaaaatacc ataacctgta
    17101 aagcaataat aaaacagatt acaaaaagta ctttagatgt gattttcatt ttataatatc
    17161 agtaaattaa caaaaaaaca agatttatgg aattttttac aagctacctt cattgccatt
    17221 taaaaactct tgagtagcat gcacttgacc atcagataat atataaagcc caaatccagt
    17281 actataaaac tcatcactaa gcatgtttgc attgtattct ggagatttct tccacacttc
    17341 aaatatagcc tttgccaagt cttttgcatc ttgagttgtt tgaacactct tagaatctat
    17401 ataaatatat gctatatttt cctcacttct cattccaaac tcagaaaata cttgtggagc
    17461 atttttgcca tctatataat gttcaaaaac tttgttatcc atcatatact tagaccatgc
    17521 atttgccata ccttctagct tactagatac taccaaaggc tctttacctt tttcttttct
    17581 ataggaattg attaagttat acatttcagt agataccatt tttttaaatt ctgggctgtt
    17641 gtaatcatga gatttatcat ccaacacttt tatttctact ctttttcctg tactttttcc
    17701 ccattcgtct gtagctttta atgtcaatat gtatgtacct actctatttg tatctataaa
    17761 cccatcaact tctattggta ataccttccc agtgttatct ttagctacta tatttaactt
    17821 gccagtgtca aacttttcac ccttatatac ctctgtactt ccaactgtaa ttgctggggg
    17881 ttgtccattt gactttgaag cacttataca ttgttgtatt accttctcat ctatttcacc
    17941 tacagaggtt atattcttag ctccttctaa tacagtttta tcgcttccat catttactag
    18001 taccattgga gagtttttag taagtggtgc agctgctatt gcatctacta attggtatcc
    18061 atctgataca tagaatccat ctgcactatt aaaaaagtag tctattacgt ttttgttagt
    18121 ttcaaatcgg tcagttcctt ctattcttac tgagtttgta tttttaacta gaggattact
    18181 cattatctcc tctgaaccta tacaatatga ttgaatattt tttacatcaa aaggcacact
    18241 ctttccatct gtaagtatga ttggagctcc atctctagta gctactgatg atacactcat
    18301 tgcatctgct tctccactat atgcattagt tagtagtact ttatcaactt tttttatagt
    18361 tgctatttct ttagctatta aatagcttgt ttttagtcta tcttctccac caattctttt
    18421 gacttctata tttttagaat ctagttcttt ttctactgat ttacttatag tatcttctgt
    18481 acctattata tatgcttttt tgatattttt tagacatcta tttgtgtctg ctggtatctt
    18541 attttgttgt gtaaatagta ttggagcttt tgtagctccc gataatccac ttgcacttaa
    18601 tccatctgca agtgattttt ctgtatttac taaaattact gtttcataag tctgtttatc
    18661 agctatcttt gctgctgttt catatctatc tttaccgtat attttttcta ctactgatga
    18721 tgcatttaca cttttgaagt ttactaagat taatgatact gctagaccta atgataatat
    18781 ttttttgttc attttcatat ccccctgatg atttttatat tttatattta tattgtgatt
    18841 attttccatt tattttctct ttattttcca tatattatag agtatatatg atatgaatat
    18901 atctcgtcta tatattagtg ttttatttta ttaaatttaa aaaattattt ttaacttctt
    18961 ttta
//
LOCUS       DAEHWM010000084        18905 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.085, whole genome shotgun sequence.
ACCESSION   DAEHWM010000084 DAEHWM010000000
VERSION     DAEHWM010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18905)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18905)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18905
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.085"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(4..540)
                     /locus_tag="KNP36_002859"
     CDS             complement(4..540)
                     /locus_tag="KNP36_002859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB-like nuclease domain-containing protein"
                     /protein_id="HBF0874718.1"
                     /translation="MEYKSPVYGIIAVPIEKIESNDYNPNAVAPPEMQLLYKSIKEDG
                     YTMPIVCYYNEEKDKYIIVDGFHRYRVMLENEDIYDRENGLLPVSVIDKSLDERMAST
                     IRHNRARGSHNVDLMSKIITELCEIGKSDEWISKHLGMEVDEILRLKQITGLAYLFKD
                     KEFGNAWIPFGSDIEEEN"
     gene            complement(558..1871)
                     /locus_tag="KNP36_002860"
     CDS             complement(558..1871)
                     /locus_tag="KNP36_002860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3440 domain-containing protein"
                     /protein_id="HBF0874719.1"
                     /translation="MDKRYLESDVFEAFQERLSYLFNEFDYIYVSFSGGKDSGLLLNL
                     VLDYKRKNNISSKIGVFHQDFEAQYSLTTEYVEKVFEDNIEDIEPYWVCLPMATRTAV
                     GNYEMYWYPWDDEKEELWVREMPVKEYIINQKNNPFTYYKYKMRQESLAKQFGRWIRD
                     IHEGAKVVCLLGTRAAESLQRYCSIVNKQHGYKGKCWITKEFKNVWTASPIYDWEIED
                     IWLAHYKFDYDYNKIYDLFYKAGVAPRKMRVASPFNDSAKESLNLYRILDPDVWVKLV
                     ARVQGVNFTSIYGKTKAMGYRSVKLPYGHTWKSFTYFLLDTLPENIRNSYIKKFSTSI
                     EFWQNTGGGLSEIVIRELLRKGYKIELNGVSNHTKDKKSRVIFLDDIPDDTDDIKFTK
                     DIPSWKRMCYCILKNDHMCRFMGFGPTKEQRIRTEYIKKKYEKIH"
     gene            2226..2666
                     /locus_tag="KNP36_002861"
     CDS             2226..2666
                     /locus_tag="KNP36_002861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3788 domain-containing protein"
                     /protein_id="HBF0874720.1"
                     /translation="MYERMLDKSNKPCLSQIIEYIGKDGYARLCKLETYLKTQYNLSR
                     ELRFPFGNNYGWGYKYSHKSFHLFYAFFEKGAFTVLIQIGDKQVPAVEKTLVALTPKA
                     KELWVTRYPCGNNGGWIKYRILEDADLLDIIQYIRAKKSPPKQN"
     gene            complement(2850..3038)
                     /locus_tag="KNP36_002862"
     CDS             complement(2850..3038)
                     /locus_tag="KNP36_002862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0874721.1"
                     /translation="MNKNNNLVIICMFIGMILGMAIGCAIGISKGNVGITMCYGLIFG
                     MIIGICIGTIIKNSNKKE"
     gene            4060..4455
                     /locus_tag="KNP36_002863"
     CDS             4060..4455
                     /locus_tag="KNP36_002863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874722.1"
                     /translation="MNILKMKKTGIFLGGVLFGTVGVKILSSDCVKKTCTRATAGALK
                     VKDSVLETTTKIQENVEDILAEAKEINEQEDLSTSKVNVVQDTLKCEQEVLKTETIKT
                     VEDTNSNSIKCEEIKDNVIEEKNSTCTTE"
     gene            4498..6597
                     /locus_tag="KNP36_002864"
     CDS             4498..6597
                     /locus_tag="KNP36_002864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HBF0874723.1"
                     /translation="MNFYIKHEIRGRIRFDLQLGKLNNKQSDTLLYYLTSINGITKAK
                     VYDRTGDAVIYYTGEREYIIREITKFSFNNSKIENLVPEHTSRELNNYYRDKLANKLL
                     VKSISKIFFPKSLRFFLIGLHSIKYFKKGLSSLLNKKIEVSVLDATAIGISIFRKDIN
                     TAGSVMFLLGIGELLEEWTRKKSIDDLAQSMSLNIEKVWLRKGDTEILIPISEIKEGD
                     LVSVTMGNMIPLDGVIVSGETMVNQASLTGESLAVNKKEGSYIYAGTVIEQGNIVMCV
                     KEKAGTTRFQKIVTMIEESEKLKSSVESKFEHLADTLVPYSFLGSILTYAITRNPIKS
                     LSILMVDFSCALKLSIPISVLSAMRECNNNNITVKGGKFLEGVACADTIVFDKTGTLT
                     KAQPTVSDIITFQNYNKEDMLRLAACLEEHFPHSIANAVVYEAEKQGLSHKEMHTEVE
                     YIIAHGISTKVDDKKVVIGSKHFVFEDEKCTIPDGEEDKYNNLSDEYSHLFMAISGKL
                     SAVICINDPLRKEAKYVISNLRECGIKKIVMMTGDSEKTAKSIASKVGVDEYYSEVLP
                     EDKANFVKSEKLKGRKVIMIGDGINDSPAISESDVGIAMSEGAEIAREISDITISADN
                     LNNLIVLKQISNKLMKRVDLSSKFIIGFNLGLILLGVGGFVRPSTSAFLHNTSTVGIS
                     LNSMTNLLENTNTYNYH"
     gene            complement(6822..12032)
                     /locus_tag="KNP36_002865"
     CDS             complement(6822..12032)
                     /locus_tag="KNP36_002865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosome-binding GTPase"
                     /protein_id="HBF0874724.1"
                     /translation="MANKLYSEIVNLLEEGRDELRKYDLKEKSILLFLGASGVGKSTC
                     INYLKGCVMEEKTDEETGQIYITAKDSAVEIGNGVYSKTLCPEVVDIANRDFSLCDCP
                     GFFDNRGAEYMIAGAMLVRETISTSSKVKGMVVILDYQSLLDSRHTLLIETGKNLKDM
                     LGDYAKYKENFFFLINKIPKTLIGNVTEEKIRNILEKAKEDLDSQEKDYDGCKELVYL
                     LNVALSDGVSIKLCNPLDKQPEKLLDEMKNLPETFEKTDLGLMLTASCKIEIQKAVDV
                     TYKDLEKLLVPYIESVKKGMEDSISILSSINSLKDKKIQLDKMYTDLCSRTNNMKELM
                     EFVQELSYGDGVQKVNILEETRLLLELNSYCSETHIVGLSELLKSLLKNTLEDTLKDI
                     KYWIAEEEYREEEAKKLEDAEYRIEKIQSCTYIKSYEKENVLSIYIPIPKVNLSDLTK
                     IISGYQLNILSSIYMYGDCELKIDCNMEKEVFSGKNIVLLTEKLHIPEGTYSINVSGK
                     DAEKLVGESSIYDGMNGRNGNNAGTSGDIILSFKEIEKRGELKLYVDGGRGGNGQDGK
                     KGDTGITGEAGANAKIGSKKESKEFANVKGTKYYVVKAEKGKQGGTGGTGGNGGNAGL
                     GSKSGQVYLLGKAPLLKSAISKKDGNHGLAGKGGSGGAGGAGGLGGIRGIYEETIRYI
                     GTSPPMDNSDRNYYYFDRYVFNHALNQKQAADDGEKLNTLYEEHKDWTISKREDSGSA
                     GAEGKAGHSGDALKEKELLKQEYSLSIDTFFYEFFERFGFSGIKGYRNLRLLCAVGIL
                     EADILEFSHIYEIFYAVEKIEMQLNREILQKYYSFEKKNKAVLSMDDMNIKKEFYKEA
                     KEIYEYLINKLMQSDRIESFVGKNQNFSEWSMILFALEQKTAFYVQMIEESEIGGNRV
                     TDIRSLTDYLDKTLRELEQGKKDELKEGYFNTYKESILTQIESGNQQIEVLKNELENK
                     MLSVNAKMNLLIQEIIKMKEDEQEDIEELKKKQAKLEEQMKTQLILSGIQSALSLLTA
                     FSGVGQACLGAFDSAKSLKENLSAKEEEYQWTNRMVDFSDFKLDSDGMRFVLGEQLSE
                     DRKNALDKMTYNLAGVDEERRTKFDQIKEIIVKSIDDDNYADKADDIQRAKEGLSESE
                     YKEIYTKIQKKEIGMLEANYNNKQQKDKLAALEKSKQAIERQQKTSKIKNALSIGSSA
                     CSLINTAISGVNNCLNVKSSFESKIEVVKEAIKDKENNIKKLDELNTQMVEFKDKTLK
                     ESVIPFVEKFDSTVKNQDIFENEISKLKMKEVLTELSTKFGSLKMENSEEISIIFKKV
                     QDMMETQIIITDKIDKKKDNLAMGELIYQMSDSGNQMNEYQKKLIHQIELNQVRYLCQ
                     VEAAAFQLWTFPFGSNIVNILNRCHVGITEDENEVINQAKEQNRQIREFLDQDAYQWQ
                     KTDNHILKVALTGSLDGKSRVGFENTYSLYDCNEEEVKKLLTGDEISFEVPLNKNFDA
                     IKYVTMYANIPNLRRNILEDSLKVKVHIHLYDSGYFSLYDDKKDVYYQYVFPQNYINI
                     THGLDIKYNDSDSINSIWSSVEDKGIEKFKNAGLNSGRSPYSMAKISLKAHFNKKLSY
                     DSLTNEQKKKLESYFDKPSKYAWSDSIDILRSLGYIDLKGILSKSWYEIKKDIDSDGE
                     IMKHFSILQVDLLERIIYEQTSILKENIPNLTIELVGCGIYVESEFNYLKQNDLKCYE
                     ERLVENTIIG"
     gene            complement(12047..14542)
                     /locus_tag="KNP36_002866"
     CDS             complement(12047..14542)
                     /locus_tag="KNP36_002866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0874725.1"
                     /translation="MPENNNQLLEEITLLLNEGKVAINKAENQNLILILGGTGCGKST
                     AINYLAGCVMMEVEDEDTGISYIDCLDPVAEIGSGAVSQTLYPNIVNMRKPIEGMDAK
                     LCDTAGFSDNRGVAHDISAAVSLGEVFKNSASICAVIVLIPEADILDSRLTKVLDLFQ
                     QLNMCLHKENFKGSITFFISKSFLGRTEKQIYNVIKRKYEQLCENLDSNIEEKAWLFE
                     ELLKDNGKNIHLCKPLASDEREGLLKQVLELDEVKDKTSAFQYPISADARLVLDTLIK
                     EIQNNIVSSLEDYVKAYTEDFINIIGSITMIQEIAKYDEVVKVFKNWLESTTSLTIES
                     FINVLAKQSGLFLQDSCMKLQNKIKGNLDIIDALSKYTEHGTGEILLPSVHMEFIIEK
                     ASKKIMEQNFIIIRKNLEKVLVSYEVQKQVFTLPNREKLMEVANKKDYVYSVSDFNSI
                     LTNVTVTQNEELEDSITRLSAYGEEGNEIIREFIGKYILNPFIVKTININDKKGIEIR
                     ALIPNLVISSVLEYFKNRKVDDNVSTFMFFAKDTIYMDDNLGMNFASEKNIILASNNL
                     DVGSNVKINVSGKSGELVDNSMYGKNGEDGRDAGNIYLYIKEEIRNYRLTLIANGGNG
                     SKGIDGENGETGASGSNGADAGYTSYFHGQMFKGYFEKGTSGKKGEKGGAGGNAGRGG
                     NAGKKGNIYFISDSEEQKNRIINHCDITVKDGEAGPNGRPGLGGYGGSGGYHGYNTLS
                     FSPSGIDKTVYYTGYFTSWDYKLDSIIKYHIEFSGGSWNEGKTGPAREYAEYGDRGDN
                     GGFNAPNTKLSTAVSKVEENLIKEKYQGYCSEI"
     gene            complement(15203..15490)
                     /locus_tag="KNP36_002867"
     CDS             complement(15203..15490)
                     /locus_tag="KNP36_002867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874726.1"
                     /translation="MRLNITKQNTIEVENSRKEDVYFVIVDNVFFERQGDVFNSITNN
                     NLNNYDVKILPTDNIFLELKITSTKDLEPVFIVVEDRQYNHGSIMFKPVLV"
     gene            complement(15510..15785)
                     /locus_tag="KNP36_002868"
     CDS             complement(15510..15785)
                     /locus_tag="KNP36_002868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874727.1"
                     /translation="MSLFVGGWSKFRAVEEEDLKVFNEAVGMLEGVGYEPLIVSTQVV
                     AGTNFKFICNATSVTNPPQNYLAEIVVFKPLPCDEHNATITSINIIK"
     gene            complement(16420..16599)
                     /locus_tag="KNP36_002869"
     CDS             complement(16420..16599)
                     /locus_tag="KNP36_002869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874728.1"
                     /translation="MGKDRFEKVYSQGKINATEIWVDKETGVNYVFHYYGNAAGFTPL
                     LDREGKPVISPIVSK"
     gene            complement(16884..18359)
                     /locus_tag="KNP36_002870"
     CDS             complement(16884..18359)
                     /locus_tag="KNP36_002870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0874729.1"
                     /translation="MKRKPQYLIIFEHIIQQIYTGKITIGDRLDSIKSMSEEYMVSKN
                     TIKTVIKMLSEKGFIETKAGSRPVLIQSTSKQSIESDLLYEKILQISEIYKIFSLIFP
                     SIAMYNIKRFTSKDFEELNEIIDCMEKNSSNYLVFKEQRLKYINKLISKTNNFLIHHF
                     CEIIQHDVIISQLAYNFDNLDNLDNCCIDFFRNKYIEQVRKTYLYGLDGNLIEFKKLL
                     TYMYKACRESILKMVENRAPQSIDTSSFNSVTLEKCYLYDLIVSDVICQIFEGNIKIG
                     DCLPSITSIINRYNVSLPTVRSAYNELNELGIAKTINGKGTYVTLFSEYDDDYINTEE
                     GAKRLSLLLDAMEFVTITLEDVVLLLGNKMDLIAVDKIETHLRYLQNNCEECKVYPDF
                     VLLCKIVDYTQIYVLQETFLHLKQYMIFGIYLERFFHEEYNEILKTRFDVCFEILRYL
                     KKGDVERFAESFSNIFKESLQYLKKVISSLNVDMRLKLGIL"
BASE COUNT         6282 a         3314 c         2074 g         7235 t
ORIGIN      
        1 tatttaattt tcttcttcta tatcagagcc aaagggaatc catgcattac caaactcttt
       61 atctttaaat aaataagcta atccagttat ttgcttcaat ctaagaattt catcaacttc
      121 catacccagg tgctttgata tccattcatc agattttcca atttcacaaa gttcagttat
      181 aattttactc attaaatcca cattatgaga acctcttgca cgattgtgtc gaatagtact
      241 tgccattctt tcatcaagag atttatcaat tactgaaaca ggaagaagtc cattttctct
      301 atcatatata tcctcatttt caagcattac tctatatcta tgaaaaccat ctacaataat
      361 atacttatcc ttttcctcat tataataaca gacaattggc attgtatacc catcttcttt
      421 tatactttta tacaacaact gcatttctgg tggggctact gcatttggat tatagtcgtt
      481 agattctatc ttttcgattg gcactgcgat gattccatat acaggacttt tatattccat
      541 agcatcttaa ctcctatcta atgaattttt tcatatttct tcttaatata ttccgttcta
      601 attctctgtt cttttgtagg accaaatccc ataaatctac acatatggtc attttttaaa
      661 atacaataac acattctttt ccaacttggt atatctttgg taaatttaat atcatccgta
      721 tcatcaggta tatcatccaa aaatatgact ctactctttt tatcttttgt atgatttgaa
      781 actccattta attctatttt ataacctttt ctcaacaatt cacgtataac tatttctgac
      841 aaaccaccac ctgtattctg ccaaaactca atagatgttg aaaatttttt aatatagcta
      901 ttccttatat tttcaggtaa ggtatcaagc aaaaaatatg tgaaactttt ccatgtgtgt
      961 ccatatggca atttaacact acgatatccc atagcttttg ttttgccata aatagaagta
     1021 aaattaactc cttgtactct agcaaccaat ttcacccata catctgggtc caatattctg
     1081 tataaattta aactctcttt tgctgaatca ttaaaaggtg atgccactct catttttctt
     1141 ggagctactc cagctttata gaataagtca taaattttat tatagtcata gtcaaattta
     1201 tagtgtgcta accatatatc ttctatttcc caatcatata taggagatgc cgtccagaca
     1261 tttttaaatt ccttagttat ccagcacttt cctttatatc catgctgttt attcacaata
     1321 gaacaataac gttgtagaga ttctgctgct cgtgttccta ataagcaaac aacttttgca
     1381 ccttcatgta tatctctaat ccatctacca aattgttttg ccaaactttc ttgtctcatt
     1441 ttatatttat aataagtaaa aggattattt ttttgattta ttatgtattc tttgactggc
     1501 atttccctta cccataactc ttctttctca tcatcccatg gataccaata catttcataa
     1561 tttcctacag cagttcttgt agccattggt aaacacaccc aatatggttc aatatcttca
     1621 atattatctt caaatacttt ttcaacatat tcagtagtca aactatattg agcctcaaaa
     1681 tcttgatgaa atactcctat tttggaactt atattattct ttctcttata atccaaaact
     1741 aaatttagca gtaaaccact atcttttcct ccgctaaaag atacatagat ataatcaaat
     1801 tcattaaaaa gataagaaag tctttcttga aaagcttcaa atacatcgga ttctaaatat
     1861 ctcttatcca tttgaattat cccctttcaa ttagaagttt ataaaacctt acaatgcaat
     1921 attattatgc ttttttagca gtaatcagca taaattatac attatttaaa tacacaaatc
     1981 caactaacta catataatta taatgtaatt atacttttgt attataaact atattttatc
     2041 attattttac atttttttcc aatatatata aatatcatat ttttctatta gctaaaacta
     2101 attactttat atttctacgt attagtataa taatacataa aaacttgaat aatgcataaa
     2161 aacttgacat actgttgtca taattacttt gctataatta aaagtaaaaa tggaggtaaa
     2221 ttctaatgta tgaacgtatg cttgataaaa gcaataaacc ctgtttgtcc caaataatag
     2281 aatatatagg taaagatgga tatgcacgat tgtgtaagtt ggaaacttac ttgaaaactc
     2341 aatataattt atcaagagaa cttcgatttc cttttggaaa caattatggt tggggttaca
     2401 aatatagcca taaatctttt catttatttt atgctttttt tgaaaaaggt gcatttactg
     2461 ttctgattca gataggtgac aagcaagttc cagcagtaga aaaaacgttg gtagctttga
     2521 caccaaaagc taaagaactc tgggtcactc gttatccttg tggcaataat ggaggctgga
     2581 ttaagtatcg tattttagaa gatgcagact tacttgatat tattcaatat ataagagcaa
     2641 aaaaatctcc acctaaacaa aattaacttt tattttttgt gatttaaata tagtgtatat
     2701 aaattccatt ctttccatat taaaaaataa tataaaaaat atctattagt ataacttatt
     2761 tagtatgtct tattctactt tttacagata attaaaaagt tttatcataa ataaatcata
     2821 actagacatc ctagtaaatc aaaattaatt tattcttttt tattcgaatt tttgataata
     2881 gtccctatac atatgccaat tatcattcca aaaattagac cataacacat tgtaatacct
     2941 acatttcctt tagaaatacc tatagcacaa cctatagcca ttccaagtat catgcctata
     3001 aacatacata taataactaa attgttgttt ttattcatag tttttctcca ttcaatatat
     3061 tttaaattgc ctagctcgcc ttcttagctt aaaacaaaga aatataaatt aactttcttt
     3121 cattctaata tctgcctgta taaatgtcaa acaacacatt tcttgtcata acctcctctt
     3181 tttgaagtaa gtacaatctc ccagacgcaa taatatcaat ttcctaaaac catttaagta
     3241 acttttatat ttacataata tttacaatca taaactatat tgttattcat ttatacatca
     3301 taaacactcc ctcctaatca ttattatact taaaataatg ttcatttata ataatatatc
     3361 taacgcactt taattgaaaa aactaaaact ttgcctttca ttcccatata taaataagta
     3421 tactttttga tgctctatta caaatcaact aaattaattg atataaatta tcattttctg
     3481 ttgaaaatac cattcgcaca tgctatactt aattgcataa atggtaataa atgtcatatg
     3541 attttacaaa tctattaata acaattatta cttttactgt attttaaagt ttttggacta
     3601 aatatcaaga actttctaaa atacaaagta caaaaaattt atataagtta taaatttata
     3661 tgaactagat aagctcaaac aatatgttat gtataaactg tgtagtattc ggttataaat
     3721 ttatataaat tatataagct agataaagta ttacctcaac tatataagct agatatataa
     3781 attgcttata taagctagat aagaattatt tcaactatat aaactacata tataaattac
     3841 atacataagc tagatatata aactgcatat ataagctata taagaattat ttcaaccata
     3901 taaactacac atgtaaaatt catataaatt tactaatata aatcaaataa aattactaaa
     3961 ctctctaaac taattttgta aaacatactc tatttttaac atttgttacc ttatacataa
     4021 gtacaaacaa aatctaacta aatgaaagga taatgtaaaa tgaatatttt aaaaatgaaa
     4081 aaaacaggga tatttttagg aggagtactt tttggtactg taggtgttaa gatactttca
     4141 agtgattgtg ttaaaaaaac ttgcactcgt gcaacagcag gagcattgaa agttaaagat
     4201 tctgttcttg aaacaactac gaaaattcaa gaaaatgtag aagatatttt agctgaagca
     4261 aaagaaatca acgagcaaga agacttatct acatctaagg taaacgttgt acaagatact
     4321 cttaaatgcg aacaagaagt tcttaaaact gaaactataa aaactgtaga agatactaat
     4381 tctaatagca ttaaatgtga agaaatcaaa gataacgtaa ttgaagaaaa aaatagtact
     4441 tgtacaacag aataaattta atgattatta tgattaataa tatcaggagg aagtaaattg
     4501 aatttttata taaaacacga aataagaggt cgtatacgct ttgacttaca acttggcaaa
     4561 ttaaacaaca agcagtccga tactctctta tattatttaa cttctataaa tggtattacc
     4621 aaagcaaaag tttacgatag aactggtgat gcagtcattt attacactgg tgaaagagaa
     4681 tacataataa gagaaatcac taaattcagt tttaacaata gcaaaataga aaacctagtt
     4741 cctgaacata ccagcaggga attaaacaat tattatagag acaaattagc aaataaactg
     4801 ctagtcaaaa gtatctccaa aatatttttt ccaaagtcct taagattttt tttaattgga
     4861 cttcattcta taaaatattt taaaaaaggt ctctcttccc tgctaaataa aaaaatagaa
     4921 gtttctgttt tagatgccac tgctataggt atttctattt ttagaaaaga tatcaatacg
     4981 gctggttcag ttatgtttct tcttggtatc ggtgaactat tagaagaatg gactagaaaa
     5041 aaatctatag acgacttggc tcaaagtatg tcactaaaca ttgaaaaagt atggttaaga
     5101 aaaggtgaca ctgaaatctt aattccaatt tcagagataa aggaaggaga tttagtaagt
     5161 gtaactatgg gaaatatgat tccattggat ggagttatag tatcaggaga aacaatggtc
     5221 aatcaggcat cacttacagg tgaatccctt gccgttaaca aaaaagaagg ctcttacata
     5281 tatgctggaa ctgtaataga gcaaggcaat attgttatgt gcgtcaagga aaaagctggt
     5341 actactagat tccagaaaat agtaactatg attgaggaat ctgaaaaact aaaatcttct
     5401 gtagagagta aatttgaaca tctagcagat acattagttc catacagctt tttaggaagt
     5461 atattaacct atgcaattac tagaaaccct ataaaatcac tctctatatt aatggtagat
     5521 ttctcttgtg cattaaaact ctctatccct atttcagtac tatcagccat gagagaatgt
     5581 aacaataaca acattactgt aaaaggtgga aaattccttg aaggtgttgc atgtgcagat
     5641 actattgtat ttgataagac aggcacatta acaaaagctc aaccaactgt ttcagatata
     5701 attacattcc aaaattataa taaggaggat atgttaagac ttgcagcttg cttagaagaa
     5761 cactttccac actccatagc aaatgcagta gtttacgaag ctgaaaaaca agggcttagt
     5821 cacaaagaaa tgcatacaga ggtagaatat attattgctc atggcatttc aacaaaagtt
     5881 gatgataaaa aggttgtaat aggtagcaaa cattttgtat ttgaagatga gaagtgtact
     5941 atcccagacg gtgaggagga taagtacaac aatctatcag atgagtattc acacctattt
     6001 atggcaatat caggtaaatt atcagcagtt atttgcataa atgacccttt acgaaaagaa
     6061 gcaaaatatg taatttcaaa tttaagagaa tgcggaataa aaaagattgt gatgatgact
     6121 ggagatagcg aaaaaacagc taaatctata gcaagtaaag ttggtgttga tgaatattat
     6181 tcagaagtct taccagaaga caaagccaat tttgttaaaa gtgaaaaact caaaggtcgc
     6241 aaagtaatta tgattggtga tggaatcaat gattctcctg ctatttcaga atcagatgtc
     6301 ggaattgcaa tgagtgaagg tgctgaaata gcaagagaga tttcagatat taccatatca
     6361 gcagataatt tgaataattt aatcgtttta aagcagatta gtaataagct tatgaaaaga
     6421 gttgatttaa gttctaagtt tattattggc tttaatttag gtctgatttt acttggtgta
     6481 ggtggatttg ttagaccaag tacatctgcc tttttacaca acacatctac tgtcggaata
     6541 agtttaaaca gtatgacaaa tttattggaa aacaccaata cttataacta ccattaatct
     6601 ccattacata aaacatatga tataaaaaat ttataattca tctttttaaa agaatatgtc
     6661 ttaaaattag cttttttcta atcaaaatta tataaagcat actttacaaa ttttaaactc
     6721 aacttatttc tattttttac aaaaaaggag atgattcaaa ttttcatttt gaaacatccc
     6781 cttttgtaaa tttctttaaa atttatatat taattatatt ttcaaccaat aattgtattt
     6841 tcaaccaatc tttcttcata gcattttaaa tcattttgct ttagataatt aaattcagac
     6901 tctacataaa taccacagcc taccaattca attgtcaaat taggtatatt ttcctttagt
     6961 atactagtct gctcataaat aattctttcc aataaatcaa cttgtaatat agaaaaatgc
     7021 ttcataatct ccccatcact atctatatct ttcttgattt cataccaact ctttgacaaa
     7081 attcccttca aatcaatata ccctagactc ctcaatatat ctatactatc gctccatgca
     7141 tacttactag gtttatcaaa gtatgattct agtttcttct tctgctcatt tgtaagtgaa
     7201 tcataagaaa gcttcttatt aaaatgtgcc ttcaaagaaa tcttagccat agaatatgga
     7261 cttctaccag agtttaatcc tgcatttttg aacttttcaa ttcctttatc ttctactgaa
     7321 gaccatattg agtttattga atctgaatca ttgtatttaa tatcaagacc atgtgtaata
     7381 tttatatagt tttgtggaaa tacatattga taatagacat cttttttatc atcatataga
     7441 gagaagtatc cactatcata taaatgaata tgcaccttta cttttaaact atcctctaaa
     7501 atatttcgtc taaggttcgg gatatttgca tacatggtta catattttat ggcatcaaag
     7561 tttttattta atggaacttc aaaactaatt tcatctcctg tcaaaagctt tttcacttct
     7621 tcttcattac aatcatatag agaatatgta ttttcaaatc ccacacgtga tttcccatct
     7681 aaactgcctg ttaatgctac cttcaaaata tggttatctg ttttttgcca ttggtaagca
     7741 tcttggtcaa gaaactctct aatctgtcta ttttgctctt tcgcctgatt tataacctcg
     7801 ttttcatctt ctgtaatccc tacatggcat ctatttaaga tatttactat attgcttcca
     7861 aatgggaatg tccatagttg aaaagctgct gcctcaacct gacacaaata tctaacctga
     7921 tttaattcaa tttgatggat aagttttttc tgatattcat tcatctgatt accactatct
     7981 gacatttgat aaatcaattc tcccattgca agattatctt ttttcttatc aatcttatca
     8041 gtaatgataa tttgagtttc catcatatcc tgtacttttt taaatattat agaaatctcc
     8101 tctgagtttt ccatttttaa gcttccaaac ttcgtgctta attcagttaa aacttccttc
     8161 atctttaatt tacttatctc attttcaaaa atatcttgat ttttaactgt actatcgaat
     8221 ttttctacaa atggtataac agattctttc aaagttttat ctttaaattc caccatttga
     8281 gtattcaatt catctaattt cttaatatta ttttctttat ctttaattgc ctctttaact
     8341 acctctattt tactctcaaa actagatttt acattaagac aattattaac accactaatc
     8401 gcagtattta taagagaaca agcagaactt ccaatactca atgcattttt aattttagat
     8461 gtcttttgct gtctttcaat agcttgttta cttttctcta gtgcagctaa cttatctttt
     8521 tgctgtttat tattgtaatt tgcctccaac atacctattt cttttttctg gatttttgtg
     8581 taaatttcct tatactcgct ttcacttaac ccctcttttg ctctttgaat atcgtcagct
     8641 ttgtctgcat agttatcatc atctatagac ttaactataa tctccttaat ttggtcaaat
     8701 ttagttcttc tttcttcatc aacacctgcc aaattataag tcattttatc taaagcattt
     8761 tttctatctt cacttagctg ttctccaagt acaaatctca taccatcaga atccaattta
     8821 aaatctgaaa aatcaaccat cctgttagtc cattggtatt cctcttcttt agctgaaaga
     8881 ttttccttca aagattttgc actgtcaaat gcccctagac aagcttgacc aacaccacta
     8941 aatgcagtca gtaaactcaa tgcgctttgt attccagaaa gaattaactg tgttttcatt
     9001 tgttcctcaa gttttgcctg tttctttttt agttcctcta tgtcttcttg ttcatcttct
     9061 ttcatcttta taatttcttg aatcaacagg ttcatttttg cattaacaga aagcatttta
     9121 ttctcaagtt cattttttaa aacctctatt tgttgatttc cagattcaat ttgagttagg
     9181 atactttcct tatatgtatt gaaatatcct tcttttaact catctttctt tccttgttcc
     9241 aattctctta aggtcttatc cagatagtct gtcaaagaac gaatatctgt aacacgattt
     9301 cctccaattt cactttcttc aatcatctgc acataaaatg ctgtcttctg ctcaagtgca
     9361 aataaaatca tactccattc gctaaaattc tgattttttc ctacaaaaga ttctattcta
     9421 tcagactgca tcaatttatt tataaggtat tcatagattt cctttgcctc tttataaaat
     9481 tctttcttta tattcatgtc atccatagaa agtactgctt tatttttctt ctcaaaacta
     9541 tagtacttct gaagtatttc tctatttaat tgcatctcta ttttctcaac tgcataaaaa
     9601 atttcataaa tatgtgaaaa ttctaaaata tcagcttcta aaattcctac tgcacacaac
     9661 agtctaagat ttctataacc tttaattcca gaaaaaccaa atctctcgaa aaattcatag
     9721 aagaatgtat ctattgacaa agaatactcc tgctttaaca attccttttc ttttagtgca
     9781 tctccagagt gaccggcttt tccctctgct ccggctgaac ctgaatcttc acgtttgcta
     9841 attgtccagt ccttatgttc ttcataaaga gtatttaatt tctctccatc atctgctgct
     9901 tgcttctgat ttaaagcatg attaaacaca tatctatcaa aataatagta gtttctatca
     9961 ctattatcca ttggaggaga ggtacctata tatcttattg tttcttcata tatacctcta
    10021 attccaccaa gacctcctgc accaccagct cctccagagc ctccttttcc tgctaaacca
    10081 tgatttccat cttttttact tatagcactt tttaataaag gagcttttcc aaggagataa
    10141 acctgtccag acttgcttcc aagacctgca tttccaccat tacctcctgt gcctccagtt
    10201 ccaccttgtt ttcctttttc tgcttttaca acatagtatt ttgtaccttt aacattagca
    10261 aattcttttg actctttttt agaacctatt ttagcatttg ccccagcttc tccagttatc
    10321 cctgtatctc ctttttttcc atcttgtcca tttccaccac gtccaccatc tacgtaaagt
    10381 ttaagttctc ctcttttttc tatttcttta aaagataata tgatatcacc tgaagtacct
    10441 gcattattgc catttcttcc attcattccg tcgtaaatag aactttctcc aaccaatttt
    10501 tctgcatcct taccagatac gttgattgaa taagtccctt ctggtatatg taatttttct
    10561 gtaagtagta caatattctt acctgagaag acttctttct ccatattaca gtcaattttc
    10621 aactcacaat ctccatacat atatatagat gacaaaatat taagttgata accagatatt
    10681 attttagtca aatccgataa attcacttta ggtataggaa tatatataga aagtacattt
    10741 tctttctcat atgattttat atatgtacaa ctttgaatct tctctatcct atactctgca
    10801 tcttcaagct ttttggcttc ttcttcccta tattcttctt ctgctatcca atatttgata
    10861 tcttttaatg tatcttctaa agtatttttt agcaatgatt ttaacaactc acttagacca
    10921 acaatatgag tctcactaca gtaactattt aactctaaaa gaagacgtgt ttcttctaat
    10981 atattcactt tctgtacgcc atcaccatat gaaagttctt gtacaaactc cataagctct
    11041 ttcatattat tagtcctact acataaatct gtatacatct tatctaattg aatcttttta
    11101 tcttttagac tatttataga agatagaatg gaaatagaat cttccatacc ttttttaaca
    11161 ctttctatat aaggaactaa aagtttttct aggtctttat aggttacatc aacagctttt
    11221 tgtatttcta ttttacaaga agctgtaagc atcaatccca aatctgtttt ttcaaatgtt
    11281 tcaggtagat ttttcatttc atccaacaac ttttctggct gtttatctag tggattacat
    11341 aatttaatag atacaccatc tgataatgct acatttaata agtacactaa ttccttacaa
    11401 ccgtcgtaat ctttctcttg actatctaag tcttcttttg ctttttccaa tatatttctt
    11461 attttttctt ctgttacatt accgattagt gttttaggta ttttattaat aagaaagaag
    11521 aaattttctt tatactttgc ataatcacca agcatatctt tcaaattttt gcctgtttct
    11581 atcaataatg tatgtctaga gtccagtagg gattgatagt ctaagataac taccatccct
    11641 ttcacctttg aagatgtgga aatagtttcc cttacaagca tagcaccagc aatcatatac
    11701 tctgctccac ggttgtcaaa aaaacctggg caatcacata atgaaaaatc tctatttgca
    11761 atatctacaa cttctggaca taaagtctta gaatatacac catttccaat ttcgacagct
    11821 gaatcttttg cagttatata tatttgtcca gtctcttcat ccgttttttc ttccatcaca
    11881 cagcctttta aataatttat acaagtactc tttccaacgc ctgaagcacc taggaataac
    11941 aaaattgact tttcttttaa gtcatatttt ctaagctcgt ctcttccttc ttccaaaagg
    12001 tttacgattt cactataaag tttatttgcc atacatccat ccctttctat atttcggaac
    12061 aatagccttg atatttttct ttaataagat tctcttctac ctttgaaaca gctgttgata
    12121 acttagtatt tggagcatta aatcctccat tgtctcctct atctccatat tcagcgtatt
    12181 ctcttgctgg tcctgtttta ccttcattcc agcttccacc actaaattct atatgatatt
    12241 taattatact atctaactta taatcccaac ttgtaaaata tcctgtatag tatacagtct
    12301 tatctatacc acttggagaa aatgaaagtg tattatatcc gtgatagcca ccacttcctc
    12361 catatccacc taaacctggt ctaccatttg gacctgcttc tccatctttc actgttatat
    12421 cacaatgatt aattattcta tttttttgtt cctctgaatc tgaaatgaag taaatattac
    12481 ctttcttacc agcatttcca cctcttccag catttccacc agctccacct ttttcacctt
    12541 ttttgccact tgtacctttt tcaaaatacc ctttaaacat ctgtccgtgg aaataacttg
    12601 tatatcctgc atcagctcca ttacttccag aagctcctgt ttcaccattt tctccatcta
    12661 ttcctttaga accatttcct ccatttgcaa tcagtgttag acgataattt ctaatttctt
    12721 ctttaatata taagtaaata ttacctgcat ctctaccatc ttcaccattt ttcccataca
    12781 tagaattatc tacaagttct ccgctctttc cacttacatt aatttttaca ttactaccta
    12841 catcaagatt gttagaagca agaataatat ttttctctga tgcaaagttc attccaaggt
    12901 tatcatccat ataaatagta tctttagcaa agaacataaa agtagaaaca ttgtcatcta
    12961 cttttctatt tttgaaatat tccaatacac tgctaattac taagtttgga attaatgctc
    13021 ttatttcaat acctttctta tcattaatat taattgtttt tactataaat ggatttaaaa
    13081 tgtatttacc aataaattct ctaattatct cattaccttc ttctccatat gcacttaatc
    13141 ttgttatact gtcttctaac tcttcatttt gtgtaactgt aacatttgtc aaaattgaat
    13201 taaaatcact tacactatat acataatcct ttttatttgc aacttccatt aatttttctc
    13261 tatttggtaa tgtaaatacc tgtttttgca cttcataaga aactaaaact ttttctaaat
    13321 tctttcttat tataatgaag ttttgttcca ttatcttctt acttgccttt tctataataa
    13381 attccatatg tacagaaggt aataaaattt ccccagttcc atgttctgta tatttactta
    13441 aagcatcaat tatatctaag tttcctttta tcttattttg taatttcatg caactatctt
    13501 gtaagaataa tccactttgt ttggctaata cgttgataaa actctctata gtaagacttg
    13561 ttgtactttc caaccagttt ttaaatactt ttacaacctc atcatatttt gctatttctt
    13621 gaatcattgt tatacttcca ataatattga taaaatcttc tgtatacgcc ttaacataat
    13681 cttctaggct agatacgata ttgttttgaa tttcttttat caacgtatct aaaactaatc
    13741 ttgcatctgc actaattgga tattggaatg ctgatgtctt atctttaact tcatctaatt
    13801 ctagtacttg ctttaataag ccttccctct catctgatgc aagtggctta caaagatgaa
    13861 tattttttcc attatctttt agcaattctt caaataacca agctttttcc tctatattac
    13921 tgtctaaatt ttcgcataat tgttcatatt ttctttttat aacattatat atttgttttt
    13981 ctgttcttcc taagaaactt tttgaaatga aaaaagttat actaccctta aaattttctt
    14041 tatgaagaca catatttaac tgttggaaca ggtctagtac ttttgtaagt ctagaatcta
    14101 atatatctgc ttctggtatc aatacaatta ctgcacatat agatgcagaa tttttaaata
    14161 cttcacctaa tgaaactgct gcactaatat catgggctac tcccctattg tcgctaaaac
    14221 ctgcagtatc acataatttt gcatccattc cttctattgg ttttctcata tttacaatgt
    14281 tcgggtataa agtttgagaa acagctcctg aaccaatctc tgccacaggg tctaagcaat
    14341 caatatatga tataccagta tcttcatctt ctacttccat cattacacat cctgcaagat
    14401 agttaattgc agtacttttg ccacatcctg tcccaccaag aattagaatt aaattttgat
    14461 tttcagcctt atttattgct acttttcctt catttaataa aagtgttatt tcttctaaaa
    14521 gttgattgtt attttctggc atttattttc ccccttggtt atatatttta tttaaataaa
    14581 gtttaatccc ttaagtagat tgcaaagttt ttagactata tttaaatttg ttttttattt
    14641 tttattttta ataaatttgc attttcacta aataattatt cttctttgtt tattaaaata
    14701 actgtgttgt ataatataat ctttatcaac acagttattt tatttaatgc gcttatttta
    14761 ttgtatttta tgtaatacag ttgtttttta tattatatgt ccattatttt tctatggtta
    14821 ttacatatag atttttaatt atatttgtac cattaattta aacattccta tactactgct
    14881 taagttttac acctatacca gcttgaatat tttattttta tttgcttaaa tagttcaact
    14941 atactggttt aaataggtta tctttatttg cttaaatagt tcaactatac tggttaaata
    15001 ggttatcttt atttgcttaa atagttcaac tatactgatt taaataggtt atctttattt
    15061 gcttaaataa gttcaactat actgatttaa ataggtttcc tttagtttaa ataattcacc
    15121 tatactggtt taaataggtt tcctttagtt taaataattc acctatacct acttgaatag
    15181 ttcactttta tttgcttaaa ttctatacca atactggctt aaacattata ctaccatgat
    15241 tgtattgtct atcttcaact acaataaaaa caggttctaa atctttagta gatgttattt
    15301 ttaattctaa aaaaatatta tcagttggta atatttttac atcataatta tttaaattat
    15361 tattcgtgat actattaaat acatcacctt gacgttcaaa aaaaacatta tcaactatta
    15421 caaaataaac atcttctttt ctactatttt caacctctat agtattttgt ttagttatat
    15481 ttagtctcat cttccacctc ctattaatat tacttaatta tattaatact tgtaattgtt
    15541 gcattatgtt catcacaagg aagaggttta aaaacaacta tctctgctaa ataattctgt
    15601 ggaggatttg taactgaagt agcattgcaa ataaatttaa aatttgttcc tgctacaact
    15661 tgagtagaaa caataagtgg ttcataacca accccttcta acattcctac agcttcatta
    15721 aatactttta aatcttcttc ttcgacagct ctgaattttg accatccacc aacaaaaaga
    15781 ctcatataaa aacctccttt atatatatat ttatttatat atagtagtac caattttctc
    15841 aatattcaat attttctgtg taactggtca atgaaaatgc ataactggat aaaaatactt
    15901 ataaaataac ttaactttac atataaatag cttactttac atgtaataag attattctac
    15961 aatatgaaat gcatcttgtt ttgaatatat tctaaataca ataatggata ttttcaatta
    16021 ttataattag aaaatatcca ttacttaact tgttttattt aaaatcacat agagacttta
    16081 ttattttttt tattgcatga atagctattt caggtatcat aaggtgatat accccctcct
    16141 tgaaaccaca aaaaacatga caaactttac gaatcttgtc ttaaaaaact acaggtacat
    16201 tccttatttg tggattggag tagccataac aagcaaattt tacaattttt atgatgacaa
    16261 aaatcaataa aatcgcttag tatataacac gaaatactac ttgttactat taagaatagt
    16321 tagataggaa gtatgcatta tacaaataaa ggaatcaata aagaaagtta aaacatccct
    16381 acaaattaaa aatctgttac atttttctat atttaaacgt tatttactta caattggaga
    16441 aataacaggt tttccttctc ggtcaagtaa aggcgtaaat ccggctgcat tgccataata
    16501 gtggaataca tagttcacac ctgtttcttt atccacccaa atctccgttg catttatttt
    16561 cccttgtgaa tatacttttt caaatctatc ttttcccatt ttataatcct ccatattttt
    16621 gattggtcta tgccttcttc acttaagtag aaaaaataca taacttattt ttttaattct
    16681 aatatgagca cgtaaaaatg tcaaacagct tatttaattt cataacttca tgttactgtt
    16741 cgtaaccttg tctgtttact tacactgcat tacagcacca ttttatcctt tacattattg
    16801 tattgcacac agtaaaaatg cttactttat gggatttttc aactaaaaaa aggattttat
    16861 ctccacaaaa catttactat ttgttacaat atacctaatt ttaatctcat atcaacattt
    16921 aatgaagata taaccttttt caaatattgt aaagactcct taaaaatatt agaaaaagat
    16981 tctgcaaatc tctcaacatc tccttttttt aaatacctaa gtatctcaaa acatacatca
    17041 aaacgtgttt tcaaaatttc attatattct tcatgaaaaa atctctctaa atagattcca
    17101 aatatcatat attgttttaa atgcaaaaat gtttcctgta atacataaat ttgtgtataa
    17161 tctactatct tacaaagtaa aacaaaatct ggataaacct tacactcttc acaattattt
    17221 tgtaagtacc ttaaatgagt ttctatttta tctacagcta tcaaatccat tttatttcct
    17281 agtaaaagta ctacatcctc aagagtaatc gtaacaaact ccatagcatc caaaagcaaa
    17341 ctcaaccttt tagctccttc ttctgtattt atataatcat catcatattc agaaaaaagc
    17401 gttacatatg ttcccttgcc attaattgtt ttagcaattc ccaattcatt tagctcatta
    17461 taggcacttc taactgttgg aagtgataca ttatatctat taattatcga agtaattgat
    17521 ggtagacaat ctcctatttt aatattgcct tcaaaaattt gacaaattac atctgaaaca
    17581 attaagtcat ataaataaca tttttccaac gttacagaat taaaactact tgtatctata
    17641 ctttgtggag cacgattttc taccatttta agtatggatt ctctacaagc tttatacata
    17701 tatgttaata gttttttaaa ttcaattaga ttcccatcca atccatataa gtaagttttt
    17761 cttacctgct ctatgtattt attacgaaaa aagtctatac aacaattatc caagttatcc
    17821 aagttatcga aattataggc caattgtgaa ataatgacat catgctgaat aatctcacaa
    17881 aaatggtgaa tcaggaaatt atttgtttta cttattagtt tatttatata ttttagcctt
    17941 tgttctttaa agactaaata attagaacta tttttttcca tacaatcgat aatctcgttt
    18001 aattcttcaa agtctttaga tgtaaatctt ttaatattgt acatagcaat agaaggaaat
    18061 attaaactaa aaatcttata tatttctgat atttgtaaaa tcttctcata taataagtca
    18121 gattctattg attgtttact cgtactctgg attaaaactg gtctagaacc agcttttgtc
    18181 tctataaagc ccttttctga gagcattttt attacagttt ttatagtatt ttttgatacc
    18241 atatattctt ctgacatgct ttttatagaa tcaagcctat ctccaatagt aattttacca
    18301 gtataaattt gttgaattat atgctcaaaa ataattaaat attgtggttt tctcttcata
    18361 tttttcctct tcgataaatt agatttattg ttttttgtaa ggtatattta cttttattta
    18421 atagggcaaa atagttgctt attttttcct cataatctat aattaatata aaccatttat
    18481 atatatggtc taagttttat aatactgtaa tgcagtaaaa tagcatgttg tagctatact
    18541 acagcaaatt aacataccat tgtagtatat taattggaat aattttaagt acttcaaaat
    18601 tccagcaaaa catatatgtg tttttgatat tatgtatatt cgttaataga atagctatac
    18661 ttgttttaca taataaatta tatgatactt gctatatgta atcactatat ttaatacaca
    18721 taactattat acttgctata tgtaattact atactttata cacatagtta tcatatatgc
    18781 tatatgtaat tactatactt tatacacata gttatcatat atactatata taattactat
    18841 acttggacac atagttatca tacatgctat atgtaattac tacacttgga cacataacta
    18901 ctata
//
LOCUS       DAEHWM010000085        18600 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.086, whole genome shotgun sequence.
ACCESSION   DAEHWM010000085 DAEHWM010000000
VERSION     DAEHWM010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18600)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18600)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18600
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.086"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            275..1435
                     /locus_tag="KNP36_002871"
     CDS             275..1435
                     /locus_tag="KNP36_002871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF819 family protein"
                     /protein_id="HBF0874730.1"
                     /translation="MIETGFVYCSFLVVFVGVIFFMVDKLKWKVFDVINPMLLIYLGS
                     AILGSFGLFAQNEDVGTYQNIITVNFLPLMLVFLLIQCDLRKILKMGPKMLLSFFCAT
                     FTFMLGFVIAFIIFKNSMGADSWKILGAASGSWIGGSSNMIAAANALGVAEEGLSYAI
                     LMGSIGYTVWMSVCLMSVKFGPKFNKWTKCDTSFIDEVTSKLEKENKDNTAPTFVELM
                     ILLSVGFGVASFAQIVSKILPTSGILNETMWVVLVASTVSILLGMTKISKLKGSTLVG
                     NVFMYLLLAATGSKANFFGLSEAPVYIMFGLVVVLVHAISFIGLAKLFKLDLFTCEVG
                     SIANIGGVTTAPMIAGVHNPVLIPVGVLMGLLGNIIGTYCALMVTQILHMLA"
     gene            1777..1938
                     /locus_tag="KNP36_002872"
     CDS             1777..1938
                     /locus_tag="KNP36_002872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874731.1"
                     /translation="MIIPSRRIQDITLTNLKNGEVTLIELDEIYKKMGFLFVVSEGKL
                     KKIKKENHH"
     gene            2131..2760
                     /locus_tag="KNP36_002873"
     CDS             2131..2760
                     /locus_tag="KNP36_002873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HBF0874732.1"
                     /translation="MKIVTYNIHKGMDSNNRLTLTKMGLYLKQLDCDVICLQEVLYPQ
                     FLALKAVLNMDGVFATNVKKVNMIYGICTFTTSKMLNSNHFFLTSKKEQRGALCITID
                     AYGRIINVINTHLGLDRQERAKQLDEIIDYRNRLVGIVILCGDFNEKNVFLSMFNDMA
                     ISLNKSYLPTFEKSNSRIDYIFVNKNTELKGYTVEKIYLSDHYPVIGYI"
     gene            2999..4258
                     /locus_tag="KNP36_002874"
     CDS             2999..4258
                     /locus_tag="KNP36_002874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanW family protein"
                     /protein_id="HBF0874733.1"
                     /translation="MGRRTTRVSRLGKEKKRSVLIVLAALVLIMGGFTYFFNSKFLYN
                     GKIAKNVYIEGVNVSDMTKAEALKAITDKYTPEDLNLAYDGKKYTISPKDIDLKYDTE
                     DVVKDAYESTKKGSYFQNLKKYIDIRVNKANMKIKAEYDEAKLSSKVSSIADSINVKM
                     KNASISVGSGGLSYTDSVVGREFDLAANKESIYNMIKNKEHKTLELKVNLQKPDITTE
                     QVKTVNSVIGQYSTTYSQAVEGRSYNVGLSARKTSDVLLMPGEEFSYNKLTGPSNKAN
                     GYKDAPVIVYGKLEQSAGGGVCQTSSTVYNAALLSGMEITQVTNHSSASTYVPKGRDA
                     TVSDGGLNLKFKNPYKHPVYIKNYAGGGSVSSVIYGNSGDKPNISIEVKQTGQNKYST
                     YRIFKDSSGKVIKKEHISNSSYKELKK"
     gene            4517..5512
                     /locus_tag="KNP36_002875"
     CDS             4517..5512
                     /locus_tag="KNP36_002875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein kinase"
                     /protein_id="HBF0874734.1"
                     /translation="MYEEVTWLNFIGNRYEVVNSDDVLEINKIYKARDVFYRKNVLIK
                     VIKHNNYICEDFVSNLIDESTALDEINSPYILKIIDVGIHCTEETTLYYVVSEDFNGI
                     GLDELILGNYLHLEAIVNIMIQVLKALEMIHRNHSYHGSLKSSSIIVDTEYNIKICDF
                     GITKANNGVNTRSYGNRRYLCPHQLCINYTDKESDFFATGLILFESIFKKLPFGESNS
                     EEKMLQSIDKGLDWNSIKAINGNTELINVIKRLLGRNNKYTRANDIIIDLSKVMYEKA
                     YIEVEDEKEEEQKQDKVIQVKKEYKSKMRKKLHKKLVVAGLAIVMISMIIISSII"
     gene            5758..6825
                     /locus_tag="KNP36_002876"
     CDS             5758..6825
                     /locus_tag="KNP36_002876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA ligase RtcB family protein"
                     /protein_id="HBF0874735.1"
                     /translation="MSNIKIIASNKCWIEDIARKQLEDISKLNGILRVVGLPDLHAGK
                     IPVGLAVETKNIIYPHIIGNDIGCGMTLFKTGVLKKKFKKDKWIKSLSKIKDLSDIEI
                     KNTYKEECPILNLGTIGSGNHFAEIQCISEIYNKEQFEQLKFSSDDIMMLVHCGSRNY
                     GEDILKKFYDKDGLEVESEKAIDYIKKHDNALMWAERNREAISKKIMQSIGTSGDVET
                     IFSINHNFIEKREDKFIHRKGAVSSERGAVIIPGSRGSLSYIVMPTENTEISLYSLSH
                     GAGRKWSRSVCKSRLKSKYSKDTIKQTKFKSQIICNDVNLLFQEAPEAYKNIEQIIES
                     LIEYELIQVVATMKPLITYKG"
     gene            7359..9269
                     /locus_tag="KNP36_002877"
     CDS             7359..9269
                     /locus_tag="KNP36_002877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HBF0874736.1"
                     /translation="MNSNTFERLQLNEVKDLIKIHCVSSLGKNLIDKLTPSGNIGVVR
                     RKLAENKEARKIIENSNHIPLEGLFNVGSTIDKIEKGMIIEPVELVNIEDFLRGCRKM
                     KAFMLEKEFYSPTLSSYALNITECKSIEDEINYCIKSNKVDSNASKELKKIRRNIEIT
                     EGKIKDRLNKFITSTVNKKYIQEFIISKRNDRYVIPIKSSYKNEVNGTILDTSSKGNT
                     VFIEPISVSNLSTELTMLKADETIEEYKILSYLTELIFEKISQIKLNIEILSEYDMVF
                     AKAKYSQKIKGITPKINNNGYIKIIKGKHPLLTGDAVPLDFEIGKNYRSLIITGPNAG
                     GKTVTLKTVGLLTLMVQCGFDISAKEGSEFSVFEKVFVDIGDNQSIENALSTFSSHIK
                     NIAEIMSLSNNSTLVLFDEIGSGTEPNEGAGLAISLLEEFYKMGCITIASTHYGEIKK
                     FATLHPEFENAGMMFDKETLEPLYKLTIGKSEDSNALFISKKMGIKNRVLDRAKEYVI
                     DRNYNLDLVKRSKLQSNIEDKNSSEVILNYTDYNVGDKVKLLDEDDFGIVYKPMDKFN
                     NVEVLFNDNFISVNIKRLQLSIKASELYPEGYDLDVLFTSFKERKLEKDIQRGSKKAL
                     KKIQKEIRENRK"
     gene            complement(9332..9955)
                     /gene="ytaF"
                     /locus_tag="KNP36_002878"
     CDS             complement(9332..9955)
                     /gene="ytaF"
                     /locus_tag="KNP36_002878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sporulation membrane protein YtaF"
                     /protein_id="HBF0874737.1"
                     /translation="MIESILLVTSLCIDAFVTSFGYGVNKVKVPLYSNIIISVVCSAI
                     LAISLFAGTIVRDFLPQNITMLICFFILFLLGSARLIESFFKSYFKKKSIHSKNYNFN
                     MLDLKLNFNVSIEPDVLDTSKSKVLKSAEAFTLALALSLDGLAIGFGSGLVGVNYIQV
                     ILFSLISNIIAVLLGCLLGNMFVKNVNLNLSWLSGLILLVIGFMKIC"
     gene            10143..10787
                     /locus_tag="KNP36_002879"
     CDS             10143..10787
                     /locus_tag="KNP36_002879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0874738.1"
                     /translation="MEQNNKVGNFGDLLKILLDEKELSMGELSKKSGIDKSTISRIAN
                     NKQKPNINHLEKMAIHLNINLEELLKASGYEFRNSNNQIFNADSDFSNFDDILGFANL
                     INDKNFNGNIEKELSKCKLYVQTDEGKKLLFDNFNKKIDSIEKQGQFTDRLRQMYADF
                     CTDGLTIKKYLLIGSMLLYFVISTDVIPDFVFPIGFMDDLVALNIVTKLLKNDK"
     gene            11001..12059
                     /locus_tag="KNP36_002880"
     CDS             11001..12059
                     /locus_tag="KNP36_002880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
                     /protein_id="HBF0874739.1"
                     /translation="MNCKWISKIDERKKCHREADSSGYCIFHKENKSDEEIQLMMDTI
                     HKEEISEFNGFVFENEFNAEEILTYNYKILDFSESIFKQKANFKKYIFKKNIIFNYTE
                     FRDKVLFNGCVFLENCDFNRSIFSKNYINDRIFEKVKFKGPDLVVNKVENFPRMDGII
                     FSMCTKFVLKNVEYGKSEYEHGKINYRIARNQATKIGEYEMIGFYYYKERIYSSKIMK
                     RSNYPTFSDYLVEKFFDQIARYTTGYGEKPWNILLVIIAIISVFALLYLFVGIESSNS
                     TLVALDINNIGDYSLSEIFKMYMDLWYFSMATFSTVGYGDMVATSLIGKALAGIEVFF
                     GVTIGAIWASVIIKRMIR"
     gene            12163..13347
                     /locus_tag="KNP36_002881"
     CDS             12163..13347
                     /locus_tag="KNP36_002881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HBF0874740.1"
                     /translation="MKNALKKIISLAMILVFIIPNYSYADDKSVDKYSKTSILIDQET
                     GRVLYSKEPDMKVPLASLSKMMTFLLAIEAIENKEVKETDKVKIDKSIASVKGSSYKL
                     KDGEEVPLIELMRGLMIVSGNDAAIAIAKHICKTKEAFVDRMNKKAKEIGMSNTHFLN
                     PNGLPIYDLSNPKKPAKENISTAKDIAILGKYMFDHYEKQVTAITDMETYTNSDRSFE
                     KSNTNALLRIIPEVDGIKTGYTGNAGYCLSFSMIVNKNDKNEKKRRVIGVVLGTNHKN
                     KRTSASLALLKYGKENFNMKKVIDKDSFIGKKYIKGMKELEVTLKAKDELYTILKDDE
                     SIKSEVKIKNIEYPVKKGDTMGIIKYYTNSGDLLGSVDIVSNNSIDNVSLKTKLKMKF
                     AN"
     gene            13554..14267
                     /gene="rpsB"
                     /locus_tag="KNP36_002882"
     CDS             13554..14267
                     /gene="rpsB"
                     /locus_tag="KNP36_002882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HBF0874741.1"
                     /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIYIIDLQ
                     KTVKKVEEAYKFTKEVAETGKPILFVGTKKQAQDAIKDEAERCGMYFVNERWLGGMLT
                     NHKTIKTRINKLRELEKMEEEGVFNVLPKKEVIKLRAEKEKLEKYLGGIKDMPELPGA
                     MFVVDPRKENIAIQEAHRLGIPVVGIVDTNCDPEQLDFAIPGNDDAIRAVKLITGAMA
                     TAVIEGRQGAEEEVAEDQE"
     gene            14346..15257
                     /locus_tag="KNP36_002883"
     CDS             14346..15257
                     /locus_tag="KNP36_002883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HBF0874742.1"
                     /translation="MANITAQMVKELRESTGAGMMDCKKALQEAEGNMEKAVDLLREK
                     GLSKAAKKAGRVAAEGLVAIEMNDDNTVASMVEVNSETDFVAKNEDFKVFVKDAACMA
                     LATDKEDIASLLGETHKEGITLQEVLNNRVAKIGEKLDFRRFAKVVTNGQVAGYIHGG
                     GKIGVLVEMETEARDAKVLELGKDVAMQVAAMNPKYVSRDEVDAEYIAHETEVLTQQA
                     LNEGKPANIVEKMVKGRLEKELKEVCLLEQTFVKNPDITVKQLVADVAKAVGSDIKVV
                     KVVRFEVGEGIQKREENFAEEVAKQLK"
     gene            15342..16046
                     /locus_tag="KNP36_002884"
     CDS             15342..16046
                     /locus_tag="KNP36_002884"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HBF0874743.1"
                     /translation="MDKPMYKRVLLKLSGEALAGERGFGINNDVVNDIAIAIKKIQEI
                     GVEVAVVVGGGNFWRGRTSEGMDRTTADYIGMLATVMNAMALQDALENIDVATRVQTA
                     IDMRQIAEPYIRRRAVRHLEKERVVIFGAGTGNPYFTTDTTAALRAAEMEAEVILLAK
                     NVDAVYDKDPKVHADAKKFTELSYMEVIQKELKVMDSTATSLCMDNKIPIKVFELTTE
                     NIIRAVKGENIGTTVK"
     gene            16072..16629
                     /gene="frr"
                     /locus_tag="KNP36_002885"
     CDS             16072..16629
                     /gene="frr"
                     /locus_tag="KNP36_002885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HBF0874744.1"
                     /translation="MKLEIHKQLEEKMNGTIDALKFEFGTIRAGRANAQMLDKIRVDY
                     YGTPTPINQIGAISVPEPRILMISPWDKSAMHEIEKAIANSDLGLNPSNDGEVIRLSV
                     PALTEERRKELAKKASKAAEEFKVRIRNERRDANEKIKKMEKGGELTEDELKKAQDEV
                     QKMTDKFIKEIDALLSKKEKDIMEV"
     gene            16632..16835
                     /locus_tag="KNP36_002886"
     CDS             16632..16835
                     /locus_tag="KNP36_002886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874745.1"
                     /translation="MKKYYNLLGLHVDEVKQYFDEQNINYTVKSIEGKKDKEKLVVPR
                     VIKISEIGDSVELIITYFSDSLV"
     gene            16864..17598
                     /locus_tag="KNP36_002887"
     CDS             16864..17598
                     /locus_tag="KNP36_002887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HBF0874746.1"
                     /translation="MNNNIIYDIDLNNIPTHIAIIMDGNGRWAKARFLPRTAGHKAGV
                     ETIRDIVKECSKLGVKHLTLYAFSTENWKRPKLEVDTLMNLLSTYLRNEIAELHQNNV
                     KVTAIGDISALPKTCIRELNSAKELTKNNTGVNLNLALNYGSRADIKNALIDIVKNCE
                     SGKIDINNIDEDIIKNYLSTKSIPDPDLVIRTSGEQRLSNFLLWEVAYSEFYFTDIHW
                     PDFKKEELQKAIYVYQRRDRRFGGLK"
     gene            17611..18390
                     /locus_tag="KNP36_002888"
     CDS             17611..18390
                     /locus_tag="KNP36_002888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HBF0874747.1"
                     /translation="MLTRIIASLALVPLFLFVVYGGIPLYIAETAIVYIALHEFYKAF
                     KIKDVHPIFIIGYLFSIYLAVKNIFNLPLEYTYAVIFILFLASIIYMLMGKNNVIDVS
                     ITFLGVFYIGVFLDFIIITINGFEKGSIYVWLIFVISFMTDIFAYFSGYLLGKHKLIP
                     KVSPKKTIEGAIGGIIGSTLCCILFGYLFGIDLLQLAIIGSIGSVIAQLGDLFASSIK
                     RYVGIKDYGKIIPGHGGILDRFDSVILVAPFVYSAIKFFIR"
BASE COUNT         7656 a         1851 c         3228 g         5865 t
ORIGIN      
        1 aaataaataa taaaatattt agtttaatta tctttacaaa taaaaatttt agtaataaaa
       61 taattgttga aaaagatttt aaattcagat tattcatttc taaagtaatt aatgtgcaaa
      121 tctttattaa tatatgtcaa tagttaggta tatatgtatt taattagcat gatatagata
      181 aaagtattta ttttaattgt ctattatctg aaaaagtctt tacttagaaa tcataaaaat
      241 caaattaatt aggaaaagaa agggtgtgta taatgtgatt gagactggat ttgtatattg
      301 tagtttcttg gttgtattcg taggtgtaat tttttttatg gttgataaat tgaaatggaa
      361 ggtatttgat gttattaatc caatgctttt aatatactta ggttcagcta tacttggatc
      421 atttggttta tttgcacaga atgaagatgt tggaacgtat caaaacataa taacagtgaa
      481 cttccttcca ttaatgttag tgtttttgtt aattcaatgt gatttaagaa aaatattaaa
      541 gatggggcct aaaatgttat tatcattttt ctgtgctaca tttacattta tgcttggatt
      601 tgttatagca ttcataattt ttaaaaattc aatgggtgca gattcatgga aaattcttgg
      661 ggcagcatct ggttcatgga taggtggctc atcaaatatg attgcagcag ctaatgctct
      721 aggagttgca gaagaaggac ttagttatgc aatacttatg ggttctatag gatatacagt
      781 atggatgtct gtttgtctaa tgtctgtgaa atttggacct aaatttaaca aatggacaaa
      841 gtgcgataca agttttatag atgaggttac atcaaaactt gaaaaagaaa ataaagataa
      901 tacagcacct acgtttgtag aacttatgat tttactttct gttgggtttg gagttgcgtc
      961 ttttgcacaa attgtatcca agatacttcc aacttcaggt atacttaatg aaactatgtg
     1021 ggtagtactt gttgcatcta cagtatcaat attattgggt atgacaaaaa tatcaaagct
     1081 taaagggagt acactggtag gaaatgtgtt tatgtattta ctccttgcag ctacaggtag
     1141 taaagcaaat ttctttggat tgtcagaagc acctgtttac ataatgtttg gattggtagt
     1201 agtccttgta catgctattt catttatagg gcttgctaaa ctatttaaac ttgatttatt
     1261 tacttgtgaa gtaggaagta tagctaatat aggaggagta actacagctc caatgattgc
     1321 tggggttcac aatcctgtat taataccagt aggtgtactt atggggcttc taggaaatat
     1381 tatagggact tattgtgctc ttatggtaac tcaaatatta catatgttag cttaataaaa
     1441 atatggtata aaattaataa tttaaataag aaaagtcatt tcaatttaag cagaagcttt
     1501 tactgaaatg gcttttttgt ttgacaagat aatctatttc aagaagatgt tttgacatat
     1561 ttagtgtata atattgtaaa atttactaaa aacgagatat atttaatttt tatattgaat
     1621 cgaacgtctg tatgatgtat aataaatata cagaacgaat gtttgcagaa cgggtgtttt
     1681 ttgaatttat tttaataatt tatgaatata tatcagaatg cataaatata tttaaatata
     1741 aagattaaaa agaatttaaa ggagtgttga taacttatga taattccatc aagaagaata
     1801 caagatataa cattaacaaa tttaaaaaat ggtgaagtaa ctttaattga attggatgaa
     1861 atatacaaga agatgggatt tttatttgtt gttagtgaag gcaaattgaa aaagataaaa
     1921 aaggagaatc atcattagaa atgaatgaaa taataaatat tataatagtt tataaaacct
     1981 aacttatgta gaatataaat acttaagtta ggtttttttg tgataaagtt tataagtact
     2041 caattttata agataaataa tggtcttaag tgaaaagtaa ataagtttaa attttagtaa
     2101 gtattatatt gcataagagg tgatattatt atgaaaatag taacctacaa tattcataaa
     2161 ggtatggatt caaataatag attaactcta actaaaatgg ggttatattt aaaacaattg
     2221 gattgtgatg taatttgttt gcaagaagta ttatatcctc aatttttagc tttaaaagct
     2281 gttttaaata tggatggtgt ctttgcgaca aatgtaaaaa aagtaaatat gatatatggt
     2341 atttgtacat ttacaacatc taaaatgtta aacagtaatc attttttctt aactagcaaa
     2401 aaagaacaac ggggagctct ttgtataact atagatgcat atggaagaat tataaatgta
     2461 ataaatactc acttgggact tgataggcag gagagagcaa aacaattaga cgaaataata
     2521 gactatagga acagattagt ggggatagtt attttatgtg gtgattttaa tgagaaaaat
     2581 gtctttttaa gtatgtttaa tgatatggct atttcactaa acaagtctta cttaccaaca
     2641 tttgaaaaat caaactctag aatagattac atttttgtta ataaaaatac tgaactaaaa
     2701 ggatacacag tagaaaaaat ttacctgtca gaccattatc ctgtaatagg ttacatttaa
     2761 atttcaatat aaatgaaatt agttgttata aaataaacaa ttttttgtta agaaatagta
     2821 aaagaaatat aataaaaaat atcaaaaata aaactaatta taagacataa atttacaata
     2881 aagttacatt tgattaaatt ccttgtttaa caaaagctat tcaaatataa tctaaggtag
     2941 ttttgaaatg ggaactctat tatgcaaatt taagctagtg ttaaaatgag gtgaagttat
     3001 gggcagaaga acaacaagag tttcaagatt aggtaaagaa aaaaaacgaa gtgttttaat
     3061 tgtattggca gctttagttc taataatggg tggatttact tattttttta acagtaaatt
     3121 tctgtacaat gggaaaatcg ctaaaaatgt atatatagaa ggagtaaatg tatctgatat
     3181 gactaaagca gaggcattaa aagctataac agataagtat actccagaag atttaaatct
     3241 tgcttatgat gggaaaaaat atacaatatc accaaaagat attgatttaa aatatgatac
     3301 agaagatgtt gtaaaagatg cttatgaaag tacaaaaaaa gggtcctatt ttcaaaactt
     3361 aaaaaaatat attgatataa gagtgaataa ggcaaatatg aagataaaag ctgaatatga
     3421 tgaggcaaaa cttagttcca aagtgtcttc tatagcagat agtataaatg ttaagatgaa
     3481 aaatgcttct attagtgttg gaagtggtgg actaagttat acagactctg ttgtaggtag
     3541 agaatttgat ttggcagcaa ataaagagtc tatatataat atgataaaaa ataaagagca
     3601 taaaacttta gaacttaaag taaatcttca aaaaccagat ataacaactg aacaagtaaa
     3661 aactgtaaat tctgttatag gtcaatattc aactacttat tcacaagctg tagagggtag
     3721 gtcatataat gtaggattat cagcaagaaa aactagtgat gtattattaa tgccaggtga
     3781 agaattttca tacaataaac ttacaggacc tagtaataaa gcaaatggtt acaaagatgc
     3841 acctgttata gtttatggta agctagaaca atcagcagga ggaggtgttt gtcaaacatc
     3901 ttcaacagtt tataatgcgg ctcttctttc gggtatggag ataactcaag ttacaaatca
     3961 ttcatctgca tctacttatg tgcctaaagg gagagatgct actgtgagcg atggaggatt
     4021 aaacttaaag tttaaaaatc catataagca tcctgtatat attaaaaatt atgcaggtgg
     4081 aggaagtgta tcatcagtaa tctatggtaa ttctggtgac aaaccaaata tatctataga
     4141 ggtaaaacaa actggtcaga ataaatattc tacatatcga atatttaaag attcaagtgg
     4201 aaaggtcata aaaaaagaac atatatcaaa tagttcttat aaagaattaa aaaaatagat
     4261 aattttttag agaaatattt gtaatataaa agggagtgtc tcaaaatgaa ctttttagtt
     4321 tatgagacac tctttttctg tgaaatcaaa tatattttca tcatttcaac aatacaaaag
     4381 aagcgtatct ctattttgag acagcctttt ttgtaaaaat taacactatt agttcttgtt
     4441 ttaatattac aatcattaat atatagaaaa tattcctata tattggtata attgtaaata
     4501 gatttagtta tataaaatgt atgaggaggt gacatggttg aattttatag gcaatagata
     4561 tgaggtagta aattctgacg acgttttaga aattaacaaa atctataaag ctagagatgt
     4621 tttttacagg aaaaatgtgt taataaaagt tataaagcac aataattata tctgtgaaga
     4681 ttttgtttca aatttaattg atgaaagtac tgctttagat gagataaact ctccttatat
     4741 actaaaaata atagatgttg ggattcactg tacagaagaa acaacattat attatgttgt
     4801 aagtgaagac tttaatggta tcggactaga tgaattaatt ctaggtaatt atcttcattt
     4861 agaagcaatt gtaaacataa tgatacaagt tttaaaagct ttagaaatga tacataggaa
     4921 tcattcatat catggtagtt taaaatcgag tagtataata gtagatacag aatacaatat
     4981 aaaaatttgt gattttggaa ttacaaaagc aaataatggg gttaatacaa gaagctatgg
     5041 aaacaggaga tatttatgcc cacatcaact atgtataaat tatactgata aagaaagtga
     5101 tttttttgca acaggtctta ttctatttga atctatattt aaaaaattgc cttttggaga
     5161 atcaaattca gaagaaaaaa tgctacaatc tattgataag ggattagatt ggaatagtat
     5221 aaaagcaatt aatggaaata ctgaacttat aaatgttata aaaaggcttc ttggaagaaa
     5281 taataagtat actagagcca atgatattat tattgattta agtaaagtaa tgtatgaaaa
     5341 agcatatata gaagttgaag atgagaaaga agaagagcag aaacaagaca aagttataca
     5401 agttaaaaaa gaatataaaa gtaaaatgag aaaaaaatta cataaaaaac ttgttgttgc
     5461 cggtctagct atagtcatga tttcaatgat tattattagt tccataatat aaaaattgta
     5521 tattaagtat tttaaaatca atgtctataa aggatataca tagaaatttt agtgtagtct
     5581 taaattatga aaggaagtgg ttattatgtt aacaaaaaat aatgaggtat taaacgtcta
     5641 ggagtatttt aacaaatagc cacctgcttt tacagtttag aataaaaaag ctgtggctaa
     5701 aggtcacagc tttttgctac tttttaaagg caggagaata ttaaaaagga gcaaattatg
     5761 agcaatataa aaataatagc aagtaataaa tgttggattg aagatatagc aaggaaacaa
     5821 cttgaagata tttcaaagtt aaatggaatt ttaagagtag taggattacc tgacttacat
     5881 gcaggtaaaa tacctgtagg tttagcagtt gagactaaaa atattattta tccacatata
     5941 attggaaatg atataggatg cggaatgact ttatttaaaa ctggggttct aaaaaagaaa
     6001 tttaaaaaag acaaatggat taagtcactt agtaagatta aagatttgtc tgatatagaa
     6061 ataaaaaaca catataaaga agaatgtcca attttaaatt taggaactat agggagtgga
     6121 aatcattttg cagaaattca atgtataagt gaaatttata ataaagaaca atttgaacaa
     6181 ttaaaatttt catctgatga tattatgatg ttagttcact gtgggtcaag aaattatgga
     6241 gaagatattt taaaaaaatt ttatgataaa gatggacttg aagttgaaag tgagaaagct
     6301 atagattata ttaaaaaaca tgataatgct ttaatgtggg cagagcgtaa tcgtgaagct
     6361 atcagtaaaa aaattatgca gtcaataggt acatctggag atgttgaaac aatattctct
     6421 ataaatcata attttataga gaaaagggaa gataaattta tacatagaaa aggtgctgtt
     6481 tcaagtgaaa gaggagctgt gattatacca ggttcaagag gcagtctatc atatatagtt
     6541 atgcctactg aaaatacaga gatatcttta tattctctat cacatggagc aggtagaaaa
     6601 tggtctcgtt cagtttgtaa atctcgcctt aaaagtaagt atagtaaaga tactataaaa
     6661 caaactaaat ttaaaagtca gattatatgt aatgatgtaa atttattatt tcaagaagct
     6721 ccagaggcat ataagaatat agagcagatt attgaaagtt tgatagaata tgaacttatt
     6781 caagtagtgg caactatgaa gccattgatt acttataaag gataattttt aaagttaaaa
     6841 aagattaaaa ttatattata aatagctaat tttatggaac atttaaaagt gttttattat
     6901 tagctatttt tttattttgt agagacgata atttatagag ctaaattctt tgatatataa
     6961 tgattacaaa gttagactgt attggaaact gcacatacat gaattgatga caatataagt
     7021 gattcccaaa tataaatgaa agtataagct tatttttact ataaaaattt tcactgtaca
     7081 aaaacattaa tgacattatt tttattgaca taaatatata atttatggaa taatattaga
     7141 agcactgata taagtgttta aataagaata gaaaaggaga agtgttttat gaaaaaaaat
     7201 actaacatta atgagtccgg agttaaactt cttaataaat aaggagtttg atatataata
     7261 actccttatt tattaagttg ttcgcaaaat aactattatc aaagtaaatg atagggtgat
     7321 ttaaaagacg atgacttata aataaaggag aaaaaataat gaatagtaat acatttgaaa
     7381 gattacaact aaatgaagtt aaagacttaa taaaaataca ttgtgtaagt tcgctaggaa
     7441 aaaatttaat agataaatta actcctagtg ggaatattgg agtagtaaga aggaaattag
     7501 cagaaaataa agaagctaga aagataattg aaaatagtaa tcacatacca cttgaaggat
     7561 tgtttaatgt aggttctaca atagataaaa ttgaaaaagg aatgataata gaacctgttg
     7621 aacttgtaaa tattgaagat tttttaagag gttgtaggaa gatgaaagct tttatgttag
     7681 aaaaagaatt ttattcacct acattaagtt cttatgcctt aaatataaca gaatgtaaaa
     7741 gtatagaaga tgagataaat tactgtataa aatctaataa agttgattct aatgctagta
     7801 aagaattaaa aaagataaga cgaaatatag aaattacaga aggaaagata aaagatagat
     7861 taaataaatt tataacatca actgtaaata aaaagtatat acaagagttt ataataagta
     7921 aaagaaatga tagatatgta ataccaatta aatcttctta taaaaatgaa gttaatggta
     7981 ctatattaga tacatcatca aaaggaaata ctgtatttat tgaacctatt agtgtttcaa
     8041 atttaagtac agagttaact atgctaaaag ctgatgaaac tattgaagaa tacaaaatat
     8101 tatcttattt aacagaactt atatttgaga agataagtca gataaaatta aatatagaga
     8161 tactttcaga atacgatatg gtatttgcaa aagctaagta tagtcaaaaa ataaaaggaa
     8221 ttactccaaa aataaataat aatggctata taaaaataat taaaggtaaa catccacttc
     8281 taacaggaga tgcagtacct ttagattttg aaataggcaa aaattataga agtcttataa
     8341 taacaggtcc taatgcagga ggaaaaactg taacccttaa gactgttggt ttactaactt
     8401 taatggttca atgtggattt gatatttctg caaaagaagg tagtgaattt agtgtatttg
     8461 aaaaagtttt tgtagatata ggggataatc aaagtattga aaatgcctta agtacttttt
     8521 catcacatat aaaaaatatt gcagagatta tgagtttatc aaataattct actcttgttc
     8581 tgtttgatga aataggaagt ggaactgaac ctaatgaagg agctggttta gcaatatcat
     8641 tattagaaga gttttacaaa atgggatgta taactatagc atcaactcat tatggagaga
     8701 taaaaaagtt tgctacattg catccagaat ttgaaaatgc tggtatgatg tttgataaag
     8761 aaacgttaga accattgtat aagttaacta ttggaaaatc tgaagatagt aatgctcttt
     8821 ttatttctaa aaaaatggga ataaaaaata gagttttaga tagagctaaa gaatatgtaa
     8881 ttgatagaaa ctacaattta gatttagtta aaagaagtaa gctacaatct aatattgaag
     8941 ataaaaatag ttctgaagtc attttaaact atacagatta taatgtaggg gataaggtaa
     9001 aattactaga tgaagatgat tttggaattg tatataaacc tatggacaag tttaataatg
     9061 tagaagtatt gtttaatgat aattttattt cagtaaatat aaaaagatta caacttagca
     9121 taaaagcatc agaattgtat ccagaagggt atgatttaga tgtattattt actagtttta
     9181 aagaaagaaa attagaaaaa gatattcaaa gaggttcaaa aaaagctctt aaaaagattc
     9241 agaaagaaat tagagagaat agaaaataaa tataaaaagc acaaaagaaa gcaatctaaa
     9301 gagaaaagtt tatctttaga ttgctttctt attaacatat cttcataaat ccaatgacta
     9361 acaagattaa accacttaac caagataagt ttaaatttac gtttttaaca aacatatttc
     9421 ctagtaaaca accaagtaat actgcaatta tatttgatat taaagaaaat agaataactt
     9481 gtatataatt cacacctaca aggccactac caaaaccgat agctaatcca tctaaactta
     9541 aagcaagtgc aagtgtaaat gcttcagcag atttaagcac tttagattta cttgtatcta
     9601 agacatcagg ttcgatactt acattaaaat ttaatttaag gtctaacata ttaaaattat
     9661 aattctttga gtgtatagat tttttcttaa aataagattt aaaaaaactt tcaattagtc
     9721 tagcacttcc taataaaaat aaaataaaga aacatattaa cattgttata ttttgaggta
     9781 aaaagtctct aactattgta cctgcaaaaa gcgatattgc taaaatagct gaacaaacta
     9841 cgctgataat tatatttgaa tataagggaa ctttaacttt atttacgcca tatccaaagc
     9901 ttgtcacaaa ggcatctata caaagagaag taactaataa aattgattca atcacagtag
     9961 attaacatcc tttctcttaa attttgtact tatattagtt atagtattgt aaaaatggat
    10021 aaattgttac agataatcca ataaattgtt gataaaattc caacatcata caacacctaa
    10081 ataacaaaag aatcatatca tataataata taaaaccaat cataataaag cgggtgaaaa
    10141 taatggaaca aaataataag gttgggaatt tcggtgattt gttgaagatt ttattagatg
    10201 aaaaagaatt atcaatggga gaactaagta aaaaaagtgg aattgataaa tctactatat
    10261 ctcgtatagc taataataaa caaaagccaa atataaatca tttagaaaag atggcaatac
    10321 atttaaatat taacctagaa gaactgttga aagcttcagg atatgaattt agaaacagca
    10381 ataatcaaat atttaatgca gatagtgatt ttagtaactt tgatgatatt cttggatttg
    10441 caaatttaat caatgataag aactttaatg gaaatattga aaaagagtta agtaagtgta
    10501 agttatatgt ccaaacagat gaaggtaaaa aattactttt tgataatttt aataaaaaaa
    10561 tagattctat tgaaaaacaa ggtcaattta cagatagatt aagacaaatg tatgctgatt
    10621 tttgtacaga tggacttaca ataaagaaat atttattgat tggaagtatg ctactttatt
    10681 ttgttatatc aacagatgtg attccagact tcgtattccc aataggattt atggatgatt
    10741 tagtagcatt aaatatagtt acaaaattac ttaaaaatga taagtaagtt ttagaatcat
    10801 atttaatata taaataaatc aaagtatata aaatttatta ttttttatat gaaacaaatt
    10861 aaaagcacaa tgaagtagat taaaaattta aaactaagaa tctaatatat attttgtaac
    10921 tatttaagta tataaaataa aataatatcc aaactaatac aaaatagtaa taattgtttt
    10981 gtactggagg atatatattt atgaattgta aatggatatc taaaatagat gagagaaaaa
    11041 aatgtcatag agaagcagat tcttctggat attgtatctt tcataaagaa aataagtctg
    11101 atgaagaaat acagttgatg atggatacta ttcataaaga agagataagt gaatttaatg
    11161 gatttgtttt tgaaaatgaa tttaatgcgg aagaaatatt aacttacaat tataaaatac
    11221 tggatttttc tgaatccata tttaaacaaa aagcaaattt taaaaaatat atttttaaaa
    11281 agaatattat ttttaactat acagaattta gagataaagt tttatttaat ggttgtgtat
    11341 tcttagaaaa ctgtgatttt aatagaagca tatttagtaa aaactatata aatgaccgta
    11401 tatttgaaaa agtgaaattt aaaggacctg atttggtagt taataaagta gaaaattttc
    11461 caagaatgga tggaataatt tttagcatgt gtacaaaatt tgtgttaaag aatgttgaat
    11521 atggaaaaag tgagtatgag catggcaaga taaattatag aatagctaga aatcaagcaa
    11581 caaaaattgg agaatatgag atgataggat tttactatta taaggaaaga atttatagta
    11641 gtaaaataat gaaacgttct aattatccta ctttcagtga ttatttagtt gaaaaatttt
    11701 ttgaccaaat agcacgttac acaacaggtt atggagaaaa gccatggaat atattattag
    11761 ttattatagc aataataagt gtttttgctt tattatactt atttgtaggc atagaaagtt
    11821 caaatagcac acttgtagct ttagatataa ataatatagg tgattactca ctaagtgaga
    11881 ttttcaaaat gtatatggat ttatggtatt ttagcatggc tacatttagt acagtaggat
    11941 atggagatat ggttgctaca agtttgattg ggaaagcatt ggcaggtata gaagtatttt
    12001 ttggagttac aataggagca atttgggcat ctgtgattat taaaagaatg ataaggtaat
    12061 atttgtgtaa atatggatag gtattaatta ctagatataa attggactaa atagggaaaa
    12121 tttaaatata aatatactta ataatccaag aaggtgaaaa atttgaaaaa tgcactaaaa
    12181 aaaattatat cattagccat gattctagtt tttataatac caaattattc atatgcagat
    12241 gataaatctg tagacaagta ttcaaaaaca tctatactta tagaccaaga aacaggtaga
    12301 gttttatata gtaaagaacc tgatatgaag gtaccattag ctagtttaag taagatgatg
    12361 acttttttac ttgcaataga agctattgaa aataaagaag taaaagaaac tgataaagta
    12421 aaaatagaca aatctattgc atcagtaaaa gggtcaagtt ataaacttaa agatggtgaa
    12481 gaagtgccac ttatagagct tatgagaggt cttatgattg tatcaggaaa tgatgcggca
    12541 attgctatag caaaacatat ttgtaaaacg aaagaagcat ttgtagatag aatgaataaa
    12601 aaagcaaaag aaataggaat gagtaataca cattttctaa atccaaatgg tcttccaata
    12661 tacgatttaa gcaaccccaa aaaaccagca aaagaaaata tctctactgc aaaagatata
    12721 gctattcttg gaaaatacat gtttgaccat tatgaaaaac aagtaacagc tataactgat
    12781 atggagacat atacaaattc agatagaagt tttgaaaaaa gcaatacaaa tgcattatta
    12841 agaattatac cagaagtaga tggtataaaa actggatata ctggcaatgc tggatattgc
    12901 ttatcatttt ctatgattgt aaataaaaat gataaaaatg agaaaaaacg tagagtaata
    12961 ggggttgtat taggtactaa ccataaaaat aaaagaacct ctgcttcatt agctctactg
    13021 aaatatggaa aagaaaattt caatatgaaa aaagtaattg ataaagatag ctttattggt
    13081 aagaaatata taaaaggaat gaaagagtta gaggttacat taaaagcaaa agatgaactt
    13141 tatacaatat taaaagatga tgaaagtata aaatcagaag ttaagattaa aaatatagag
    13201 taccctgtta aaaaaggtga tactatgggt attataaaat attatactaa ttcaggtgac
    13261 ttacttggaa gtgtagatat agtaagtaat aatagtatag ataacgtatc attaaaaaca
    13321 aaattaaaaa tgaaatttgc aaattaaatt caaaaaatgg tataaaatac acaaaaaaat
    13381 ataaaaatag aaaatatgga aaaaatattg ttatttcttc acctctgtga tatactacta
    13441 gaggtgaaaa aataaaataa atcacacaca gcattgggat ccttaaaagg tgcctattac
    13501 atggtttttt agggagaaga tcaagctgga ggtataaaac caggaggtaa gatatgtcag
    13561 taatatcaat gaaacaatta ttagaagcag gtgttcactt tggtcaccaa acaagaagat
    13621 ggaaccctaa aatggctaag tatatattca cagagagaaa tggaatatat ataatcgact
    13681 tacaaaaaac agttaaaaaa gttgaagaag cttacaagtt cactaaagaa gtagctgaaa
    13741 caggaaagcc aatcttattc gtaggaacta aaaaacaagc tcaagatgcg ataaaagatg
    13801 aagctgaaag atgtggaatg tactttgtta atgaaagatg gttaggtgga atgttaacaa
    13861 accacaaaac tataaaaaca agaataaata aattaagaga attagaaaaa atggaagaag
    13921 aaggcgtatt taatgttctt cctaaaaaag aagttataaa attaagagct gaaaaagaaa
    13981 aactagaaaa atacttaggt ggaataaaag acatgcctga attaccaggt gcaatgttcg
    14041 tagttgaccc aagaaaagaa aacatagcta ttcaagaagc tcatagatta ggtataccag
    14101 tagttggtat agttgatact aactgtgacc cagaacaatt agactttgct ataccaggaa
    14161 atgatgacgc tataagagcc gtaaaattaa taactggtgc tatggcaaca gctgtaattg
    14221 aaggtagaca aggtgctgag gaagaagtag ctgaagacca agaataataa tttgacaatt
    14281 aaatggtaag ggtcgccctt accatttata atatggaata gaataagtag gaggaaactt
    14341 aaaaaatggc taatataact gctcaaatgg taaaagagtt aagagaaagt acaggcgcag
    14401 gaatgatgga ctgcaagaaa gctttacaag aagctgaagg aaacatggaa aaagcagtag
    14461 atttattaag agaaaaagga ttatcaaaag ctgctaaaaa agctggtaga gttgctgctg
    14521 aaggtctagt tgcaatagaa atgaatgatg ataatacagt tgcttctatg gtagaagtta
    14581 actcagagac agatttcgtt gctaaaaacg aagacttcaa agtgttcgtt aaagatgctg
    14641 cttgtatggc attagctact gataaagaag atatagcttc tttattaggt gaaactcata
    14701 aagagggaat aactttacaa gaagttttaa ataatagagt tgcaaaaata ggtgagaaat
    14761 tagactttag aagatttgct aaagttgtaa ctaatggaca agttgctgga tacattcacg
    14821 gtggtggaaa aataggtgtt cttgttgaaa tggaaacaga agctagagat gctaaagttt
    14881 tagaattagg taaagatgta gctatgcaag ttgctgctat gaatcctaag tatgtttcaa
    14941 gagatgaagt agatgctgaa tacatagcac atgaaacaga agtattaact caacaagctt
    15001 taaatgaagg aaaaccagct aatatagttg aaaaaatggt taaaggaaga ttagaaaaag
    15061 aattaaaaga ggtttgttta ttagagcaaa ctttcgttaa aaatccagat ataactgtta
    15121 aacaattagt tgctgatgtt gctaaggcag taggttctga tataaaagtt gttaaagttg
    15181 tgagattcga agttggtgaa ggtatacaaa agagagaaga aaactttgca gaagaagttg
    15241 ctaagcaact taagtaataa ccaaagagag aacacgcagg tgttctcttt tttaaaaaat
    15301 agaaaaaatt ggatatgaag gattgaaata ggaggtttct gatggataaa ccaatgtaca
    15361 aaagggtatt gttaaaatta agtggagaag cattagcagg agaaagaggt tttggtataa
    15421 ataatgatgt agttaatgat attgctattg ctataaaaaa aatacaagaa ataggtgttg
    15481 aagtagctgt agtagtaggt ggaggaaact tctggagagg cagaaccagt gaaggaatgg
    15541 acagaactac tgctgactat ataggaatgt tagctacagt tatgaatgca atggcgctac
    15601 aggatgcact agaaaatata gatgttgcta caagagttca aactgctata gacatgagac
    15661 aaattgcaga accatatata agaagaagag cagttagaca cttagaaaag gaaagagttg
    15721 ttatatttgg tgcaggaaca ggaaaccctt actttacaac agatacaact gctgctttac
    15781 gtgctgctga gatggaagca gaagttatat tgttagctaa aaatgttgat gcagtatatg
    15841 acaaggatcc aaaagtacat gcagatgcta agaaatttac agaattaagt tacatggaag
    15901 ttatacagaa agaattaaaa gtaatggatt ctacagctac atctttatgt atggataata
    15961 aaattccaat aaaggtattt gagcttacaa cagagaatat aataagagca gtaaaaggcg
    16021 aaaatatagg aactactgta aaataatgaa gaatgaagga ggagtaaaat tatgaaactg
    16081 gaaatacata agcaattaga agagaaaatg aatgggacaa ttgatgcttt aaagtttgaa
    16141 tttggaacta taagagcagg aagagctaat gcacaaatgc tagacaaaat aagagttgat
    16201 tattatggaa ctccaactcc aataaatcaa ataggtgcta tatctgtacc agaaccaaga
    16261 atattaatga tatctccttg ggataaatct gctatgcatg aaatagaaaa agcgatagct
    16321 aactcagact taggattaaa tccatcaaat gatggtgagg ttataagact ttctgtacct
    16381 gctttaacag aagaaagaag aaaagaatta gctaaaaaag ctagtaaagc tgcagaagaa
    16441 tttaaagtta gaataagaaa tgaaagaaga gacgccaatg agaaaattaa aaagatggaa
    16501 aaaggcggag aattaactga agatgaatta aaaaaagcac aagatgaagt tcaaaaaatg
    16561 actgataaat ttataaaaga aatagatgca ttattatcta aaaaagaaaa ggacataatg
    16621 gaggtataat attgaaaaaa tattataacc ttttaggtct tcatgtagat gaggtaaaac
    16681 aatattttga tgagcaaaat ataaattata ccgtaaaatc tattgaaggt aaaaaggata
    16741 aagaaaaact tgtagttcct agagttataa aaatatctga gataggtgat agtgtagaac
    16801 tgataatcac atacttttct gactccttag tttaaggagt cagaacaata ttggaggcaa
    16861 aatatgaata acaacattat atatgatata gacttaaata acatacctac tcatattgct
    16921 attataatgg atggaaatgg aagatgggca aaagctagat ttcttccaag aactgcagga
    16981 cataaggctg gagtagaaac tataagagat atagtaaaag aatgctcaaa attaggtgtt
    17041 aagcacttaa cattatatgc attttcaaca gaaaactgga aaagaccgaa acttgaagtt
    17101 gacacactta tgaacttatt atctacatac ttaagaaatg aaatagctga acttcaccaa
    17161 aacaatgtaa aagtaactgc tataggagat ataagtgctt taccaaaaac ttgtataaga
    17221 gaattaaact cagctaagga actgacaaaa aacaatacag gagttaactt aaatttagca
    17281 ttaaactacg gaagtagagc agatataaaa aatgctctta tagatatagt aaaaaattgt
    17341 gaaagtggta aaatagatat aaacaatatt gatgaagata ttataaaaaa ctatttaagc
    17401 acaaagtcta taccagatcc agacttggta ataagaacaa gtggtgaaca aagattgagt
    17461 aactttttac tttgggaagt tgcttattct gagttttact ttactgatat acattggcct
    17521 gattttaaaa aagaagaact acagaaggct atatacgtat atcaaagaag ggatagaaga
    17581 tttggaggac ttaagtaagg agattatttt atgcttacaa gaattattgc ttcactagct
    17641 ctggttccat tatttctatt tgttgtatat ggaggtattc ctctatatat agctgagaca
    17701 gcaatagttt atattgcatt gcatgagttt tataaggcat ttaaaataaa agatgtacat
    17761 ccaatattca ttataggata tttattttct atttatttag ctgtaaaaaa tatttttaat
    17821 ttaccattag aatatactta tgcagtaatt tttattttat ttttagcaag tataatttat
    17881 atgttgatgg gcaaaaacaa tgttatagat gtttcgatta cgtttttagg agttttttat
    17941 ataggagtat ttttagattt tataattata actataaatg gatttgaaaa aggtagtata
    18001 tatgtatggc ttatatttgt gatatctttt atgacagata tatttgcata ttttagtggt
    18061 tatttacttg gaaaacataa gctaattcct aaagttagtc ctaaaaagac tatagaagga
    18121 gctattggag gaataatagg aagtacactt tgttgtattt tatttggata tttatttggc
    18181 attgatttgc ttcaattagc gataatagga agtataggaa gtgtaatagc tcaattagga
    18241 gatttatttg catcttctat aaagagatat gtagggataa aggattatgg aaagataata
    18301 cctggtcatg ggggtatatt agatagattt gatagtgtta tattagttgc accttttgta
    18361 tatagtgcga ttaaattttt tattagataa agattggttg gatttaaaag agcaatctat
    18421 aattgctagt aatgaaaata gctatgtaac ttttaaatgc agagatattc tgcagttatt
    18481 agttacatgg ctattttcat tgttcaaaaa tttagaagac cttggggaat tgtataagaa
    18541 taggtattac tttataatag tatactatat ttgtagtgag tatatttttt atactgtaac
//
LOCUS       DAEHWM010000086        18507 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.087, whole genome shotgun sequence.
ACCESSION   DAEHWM010000086 DAEHWM010000000
VERSION     DAEHWM010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18507)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18507)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18507
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.087"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     regulatory      45..147
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            241..1617
                     /locus_tag="KNP36_002889"
     CDS             241..1617
                     /locus_tag="KNP36_002889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HBF0874748.1"
                     /translation="MQTTNSSTMQKLFPILTNKNVDMKKEIIAGVTTFLTMAYIIAVN
                     PNILSETGMPAGALVTGTCLAAAFGCILMGVVANLPFALASGMGLNAFFAYTVVLQMG
                     VPWEVALTAVFVEGIIFIVLSVSGVREAVVNAIPKNMKLAVTGGIGIFIALIGLVNSG
                     IVIGDQATLIKMGRFTPAVIITCVGLIIIAVLDKKRVKGSILFGIVVSSLLAWAFAFI
                     NPEYAQKLGIYLPGGLFKFESLAPIAGKIDLGYVLHPTNIGGFLVVVCTFLFVDFFDT
                     VGTLVGVCSKANMLDEKGNVPNVGRALLTDAVATTVGAGLGVSTVTTYVESSTGVIAG
                     GRTGWTAITVGILFLAAMFFSPVFIAIPSCATAPALIYVGYLMLGTVKDIEFDNITEG
                     VPAFVTIACMALTYSIGDGLTLGILTYVFVNIFYNIFGAKKAEDKKHVSVVMIVLAIL
                     FIIKLWLL"
     gene            complement(1731..2876)
                     /locus_tag="KNP36_002890"
     CDS             complement(1731..2876)
                     /locus_tag="KNP36_002890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBF0874749.1"
                     /translation="MNTFEQLKISSTLIDGLKKQDITSPTEVQSLVIGNIIQNKDLLI
                     NSQTGTGKTLAYLLPIFEKIDTSKRETQALILAPTHELVMQITNQVELLAKNAELSVT
                     SLALIGEVNIQKQIKNIKAVKPHIVIGSCGRVLDLIKQKKLKSHNIKTIILDEVDNLL
                     NGKNITCIEDIIRTTLRDRQIIGCSASLTDSTIKICDKLMKEFEIIKTKEKSQINPNI
                     NHSYLLGEIRDKFTFLRKALAATNPKKAIVFVNNEKNIEVLVSKLNYHNYKAIGIFGN
                     MEKEDRKNAINKFKLGKAKILITTDLSARGLDIVDVSHVFNLDFPKSKNEYLHRCGRT
                     ARGNRSGNTISIITKKELDIIKDLQKEFNIVITPKTLQNGELIDIIK"
     gene            3129..3836
                     /locus_tag="KNP36_002891"
     CDS             3129..3836
                     /locus_tag="KNP36_002891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874750.1"
                     /translation="MLKVINVSKSYKNKKVVSSVSFDVNDGELFGFIGHNGAGKTTTI
                     KAIVGIHDFEEGEVLINSKSIKKQPVECKKEMAYIPDNPDLYESLTGIQYLNFIADIF
                     EVAKDKREELIKYYSNKFELNKALGDLISSYSHGMKQKLAIISALIHSPKILILDEPF
                     VGLDPKASFILKEIMREFCDKGGCIFFSTHVLEVAEKICDKIAIIKDGNIIAYGTTEE
                     VKGSNSLESIFMELIEK"
     gene            3883..5478
                     /locus_tag="KNP36_002892"
     CDS             3883..5478
                     /locus_tag="KNP36_002892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874751.1"
                     /translation="MSNLSILIKTNIINEFKLNALKKADGREKQKIMGMMLSVVIIAG
                     LLIFYVTSLSLSLVDILKQINQLEMLLIFGFGLSTLTTIVTSLYKTSSYLFQAKDLDL
                     LTSLPIKESTVLASKILMLVGANYLFSSICMIIPAVVYFLNSDVSITYFPYLILLFLA
                     LPLLPIVASSIIFLFIGQISSRIKYKNLVLIIGSIILMLLYTLLMSRLNSMSVEMLKN
                     SVSISETIRKVYPPIYYFVDALKTGSIVSFLAFIAISIIPFFMFVTLFAKKFKDINAK
                     MSEGYKSKNYEFKGQKTSRPSKALLKKEFKRYTSSFIYFLNSSAGLLFLMVGTILILL
                     FGADKVGELLKLNIDFNLIKIQLLGVFFFIIVMNCTTYCSISLEGKNLWILKSSPIDE
                     REIFWSKILMNFLLNAPLSILCLILVSIRLDFEIQFIIVSICLIVSFSMFVALMGLLS
                     NLLYPNLDWKNEVAVVKRSASMIVTMLVSLAYVIILGGIYVLLGISFLNIYIILASIL
                     TLILDFMIWRIISTKGVRIFKNL"
     gene            5581..6663
                     /locus_tag="KNP36_002893"
     CDS             5581..6663
                     /locus_tag="KNP36_002893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flippase-like domain-containing protein"
                     /protein_id="HBF0874752.1"
                     /translation="MRKLSKREKDFIQYGFLLFLICITTYLVLTTLDIKLIPKIIRLV
                     NKTYIFLGILTIIVYMIIESIVTHLIINAVQKTKVKFIGIKMATMGFYYNLVTPFASG
                     SQPMQIYALTKYDVSLSKSVAIVTNKTVVFQSTVTVFCGILILLNKSLLMEQVHSVKV
                     LITFGMIMNVSMLLGGLLIVFSPKQVKMIAEVLINFLSKFKTFKFLDSKRDRINHYID
                     DYNYSIKIFIKNVRILVLSILLTVLQLIAYFSIVYCVYKASNLRGVSYVHIMTLQVFL
                     YMAISPIPTPGNVGANEVTFFTMFSNIIPKELLGYSVLLYSGFVYYFILIVSGLFTFG
                     THYTLNSWKKENKVNSNLDKVIEKLN"
     gene            6812..6973
                     /locus_tag="KNP36_002894"
     CDS             6812..6973
                     /locus_tag="KNP36_002894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III"
                     /protein_id="HBF0874753.1"
                     /translation="MKQDKQNEKQSEISKIKQSNDNKLEIAQELHVSKNIGNMLGYRI
                     DKKKMNRPS"
     gene            7314..8582
                     /locus_tag="KNP36_002895"
     CDS             7314..8582
                     /locus_tag="KNP36_002895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HBF0874754.1"
                     /translation="MEASIHTIASNNLLIIFAIVSITGIICSKLSEIIKVPDVVLYLL
                     VGILIGPSFLKFIDIRGFQIENQLILTFGSAFILYLGGKEISLKVLRNVKISVFLLAT
                     LGVVISAFIMQQVIGFTFGISAMTALLAGTIIASTDPATLVPIFNQVKIKDRVKQTVI
                     SESAFNDATGAILTSAVLAVILSNKFSLGENIYELGTMVIVGVLVGLITGILLLKLVN
                     DKPYGIFKDFAPIISVISVVVAYELSTKLGGSGYMSCFIVGIITGNKKNFKIWLSQKS
                     YDADFYVAETLGTICRMAIFIILGSQVNLAQLSKYFMPSVITVLVLMFIARPLCVLVC
                     TLVDREAKWSKSEILFMMWVRETGVIPAALCGIISAMKVPGYEVISSVVFMTILITLV
                     IQGSTTKLVAKKLGLLEEEVINISEKVSTF"
     gene            8777..9565
                     /locus_tag="KNP36_002896"
     CDS             8777..9565
                     /locus_tag="KNP36_002896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD binding domain-containing protein"
                     /protein_id="HBF0874755.1"
                     /translation="MFTVMDIVQPDTVEEAYSILNKRKTNQVIGGSAFLRMGKKRIGT
                     GIELSKLNLDYIKEYEDYVEIGSMTTFRTLETSSIIKNNFGRIIEDSVKNIIGVQFRN
                     VVTVGATVFSKYGFSDLIVALLSLDTEVELYNIGRISLEEFLNRDYEKDLLIKIYIKK
                     TNKNASYKSIRNAKSDYPILNVSVSKHMEQFKLCVGARPQKATIAKQASEFLSNNEIN
                     EINIDKAVEIASEELTFGSNMRASREYRKAMSKVLLKRAIMEVI"
     gene            9565..10014
                     /locus_tag="KNP36_002897"
     CDS             9565..10014
                     /locus_tag="KNP36_002897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2Fe-2S iron-sulfur cluster binding
                     domain-containing protein"
                     /protein_id="HBF0874756.1"
                     /translation="MLVKININGKKKSVDIEPEEYLVDTLRKVGNLSVKRGCDTGCCG
                     LCTVLIDKKPTLSCATLTLRALDKEITTIEGLENEVKEFSEVLVKEGAEQCGFCSPGF
                     ILTVLAMKDELENPTDDEIKHYLTGNLCRCTGYMGQLRAIKTYLEVK"
     gene            10018..12282
                     /locus_tag="KNP36_002898"
     CDS             10018..12282
                     /locus_tag="KNP36_002898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBF0874757.1"
                     /translation="MNIVGKGIKKIDGMSITTGKPVYTDDLSAKDALVVKILRSPHAY
                     AKIKDIDTSKAEMVDGVECVLTYKDVPKSRFTLAGQTYPEPSPYDRLILEDVVRYVGD
                     EVAIVAAIDEKTAIKAMNLIKVKYEVLTPVLDFEEAIGNKTMVHDEDRHCNFDIGMQR
                     EKNIVSHHDYTKGDVEKVLSNCDVVIEETYYTQAQAHAMMETYRAYNYLDHMGRLVVV
                     SSTQIPFHVKRHLSRALEIPASKIRVIKPRIGGGFGGKQTACVEIFSAIVTLKTGKPA
                     KIIYDRKETFNCSTSRHAMRLKVRLGATNDGIIKAIDIKALSDTGAYGEHASTTIGLV
                     GEKTLPMYNKVEATRFIADVVYTNKMPAGALRGYGASQGCFAVESTINMLANKLKMDP
                     TDLRLKNVVTEGETTFAYGKTLNSVDLIKCINKGKELIGWNEKYPCKHLDNGKIRSVG
                     MAITMQGSGIQGLDKSSAEIKLNDCGDYTLMIGSTDMGTGSDTILAQMAAEVLDTSIE
                     NITVISADTDLVPYDPGSYASSTTYVTGMAVVKAAQDLREKIISAGATKLGVEKDEVE
                     FDGIKLTSKKGSTLLFDIAVDSTIGPDTNQLIGLASHGSPVSPPPFIAGFAETEIDTE
                     TGKVDLVNYVAVVDCGTVINKNLAKIQVEGGIVQGIGMALFEEVRYTEKGSMDTNTFM
                     QYKIPARCDIGNVKVDFVETYEPTGPFGAKSVGEVVINTPLPAIQEAVFNGIGVRINT
                     LPITPEKVFMEMNK"
     gene            12422..12733
                     /locus_tag="KNP36_002899"
     CDS             12422..12733
                     /locus_tag="KNP36_002899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874758.1"
                     /translation="MAGNLNNMRAVNNFRGDKNILECLVSFEGRSISQRKVRVFFKEK
                     QNQIEIDFAEEEISKLVENVVLNTSYQEMLYDEIEKQLEIDCIGTWMILSKLKDGSRV
                     H"
     gene            13019..13519
                     /locus_tag="KNP36_002900"
     CDS             13019..13519
                     /locus_tag="KNP36_002900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HBF0874759.1"
                     /translation="MRKNSINIALTAAITAIYAVLTLSLGFISYGPIQFRVAEIMMLL
                     AFLDKGYIVGLTLGCFLANVIGPYGVPDIIFGTLATFISASMIYITRKLGKQNKSTLV
                     IASLWPTVINSIVVGLMLNVFFGLPLILSMIQVGFGEFVVVTIVGVPFFCFLMKKYKN
                     VINIKF"
     gene            13576..14562
                     /locus_tag="KNP36_002901"
     CDS             13576..14562
                     /locus_tag="KNP36_002901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /protein_id="HBF0874760.1"
                     /translation="MSKVKRLTDVWIYINDKQKFTIKELSEEFNLSAKTIQRYLKELN
                     KMGLPIQAEQGRNGGYRVLNNSYIPPVIFTEKEVMIILFALKSLQIYNYKLMEIEINS
                     IMRKVSYERKSSIKVGIENIKRYIGFVANDTNDGDFKSSNVTEFFRASSESLILNIKY
                     KCGNQILEKNVCPIGIYLNKGAWFSPAYDCKSDKIILVHIDNIIDIKRTGESKKIHIN
                     LEEWLHEVYNNLYGNSSTTKKFGEIIYLNVLLTKEGVSKIKDSSWNLDMELNEDGSGI
                     ISTFIKVEDIDCYASILFFIGNNAKVIEPKFLNKLLYDKANELRYFYEENMV"
     gene            14612..15334
                     /locus_tag="KNP36_002902"
     CDS             14612..15334
                     /locus_tag="KNP36_002902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein"
                     /protein_id="HBF0874761.1"
                     /translation="MENFNKNAKIIGIGAEGINIINEVEEKIKANMDIEKININQEIE
                     KEYVRSLLDGVDILFLIYSSEDKHIRDIIKAVSYMSNERRVLSIGMDCSEKENKEDLE
                     LGREFKINNDSIFKFVDLMNIMVESISDSCMINIDITDLKEAIVGDKGIKYSFEEFED
                     TKSYSEIADILFDRMEYIGEEFISKKGIVFVEGSPEFSIMELNDLISNIQSKVEESYE
                     VIFSLYIKENLNGNIRVGLLYN"
     gene            15363..17297
                     /locus_tag="KNP36_002903"
     CDS             15363..17297
                     /locus_tag="KNP36_002903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0874762.1"
                     /translation="MSENIRGTEYWLMEEFFYQETDTPQIFREESIIALGFDIKINLK
                     KVFSMGKKSEKYINENCNDKDFIKKFMSIKKGDYFLYKAYQNIEEKVKCNVSIGIVEE
                     DFENGYELSHILGHTLPVKWMHNFDTVSNCKVYTSEFYKLNNNDISSYLEIIKSQDKK
                     LLRKRIEESENNKWYLKNYYYKNVDKCVDDEELFIQPINLEQLESLKNIKTDDYILLY
                     NSEKVICENDHTMKSLFGVCQVMEGFDKEKVSALEGGYFFPVRWIEYEKENIDGNAWV
                     IFENNSIVEKYVKRFTNKMPLNTILYGPPGTGKTYNTKQMVYNLVSETSLRNRYYTGY
                     LDYKNNVEFCTFHQSYGYEEFIEGLKSDGEGNFKPEDGILKDISIEACYNALKFEKKM
                     SFELEKDSLTLETIKDRKKKLVLENIEYSESFNFEESENYVLIIDEINRGNVSKIFGE
                     LITLLEDDKRLTKSNQTIVKLPYSKEKFSLPPNLYIVGTMNTSDKSIALLDIALRRRF
                     NFEEIMPDYDLLSIVDGIDIRKMLYTINKRIEFLYDRDHVIGQAYLLAVENINDIVVV
                     FRSKIIPLLQEYFYYDSEKVGLILGGIGRNEKDKYIVYKEKLIASELFKNNNASIMES
                     KVNYCIKQNISSEELKNIYE"
     gene            17290..>18507
                     /locus_tag="KNP36_002904"
     CDS             17290..>18507
                     /locus_tag="KNP36_002904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HBF0874763.1"
                     /translation="MSKNIYVKETYEWIRIGNGENELTEIEYEKLLKYLENNNDVLKS
                     NIIDIKYKKLRFINYVGIICFENVILEILPKLSLSDNLVKDREILLQMLSICNKIPIT
                     MNEKIRLSLKNYNLLNFFVMYFIESMQTQMKKGIYFEYINKIENLNVMRGKILLSTYA
                     KEKGISPMKIRCEYDEYSENNFLNQVLKKACISILCRINDNSIQGKIKKILSYFQNVD
                     LIYIDRKKLLDYKFYKNNDRFKDCYLLARLLLLNLSMDNSQNNQEAFSILFEINTLYE
                     EYIGILIKSIWDNSFRETYIQDKSKFLLKNEQTGKKNFNLRPDIVLYDLKNEYEIIID
                     TKWKAIEVDSNVFYRSSDIYQMYAYITAYENAKRCILLYPCIQKDKNYSSWKLSESFK
                     GKFIEAKTVRLDDI"
BASE COUNT         7069 a         1825 c         3162 g         6451 t
ORIGIN      
        1 gacaaaatta attatataaa ttaaaataat attcgtaaag aaaaattcat gttttgtact
       61 gtataacata taattttgac aatatgggtc ataagtttct accggaatac cgtaaatatt
      121 ctgactatgt atactattat ttagttaatt aaatatttaa ttaactgaat tatgaaggat
      181 acggctcagc ttatcaacta ctgtgtcgtt tttttgtaaa atttaatagg aggtgttgtt
      241 atgcaaacaa caaacagtag tactatgcag aaactttttc caattttgac taataaaaat
      301 gtcgacatga agaaggaaat aattgcagga gtaactactt ttttaactat ggcttatata
      361 atagctgtaa atccaaatat tttatctgag acaggcatgc ctgcaggtgc acttgttaca
      421 ggtacttgtt tagcagcagc atttggatgt attttaatgg gtgtagttgc taaccttcct
      481 tttgctttag catcaggtat gggtcttaat gcattttttg catatacagt agttttacaa
      541 atgggtgttc cttgggaagt agctcttaca gcagtatttg tagaaggtat tatttttata
      601 gtattatcag taagtggagt tcgtgaggct gttgtaaatg cgataccaaa aaatatgaaa
      661 ttagctgtta caggtggtat aggaatattt attgcactta taggtctagt taacagtgga
      721 attgttattg gagaccaagc cactcttatc aaaatgggta gatttacacc agcagtaata
      781 ataacttgtg taggattaat aattattgct gtattagata aaaaaagagt taaaggttct
      841 atactttttg gaatagtagt gagttcatta cttgcttggg catttgcttt tataaatcca
      901 gagtatgcac aaaaattagg tatatattta cctggtggat tatttaaatt cgaaagttta
      961 gcaccaatag caggtaaaat agatttagga tatgtactac atccaacaaa tataggtggt
     1021 tttttagtag tagtttgtac atttttattt gttgattttt ttgatacagt aggtacatta
     1081 gttggtgttt gttctaaagc aaacatgtta gatgaaaaag ggaatgttcc taatgtaggt
     1141 agagccttac ttacagatgc ggttgcaact acagttggtg caggacttgg agtatctaca
     1201 gttacaactt atgttgagag ttcaacagga gttatcgcag gtggaagaac tggatggaca
     1261 gcaataacag ttggaatttt attcttagct gcaatgtttt tctctcctgt atttatagca
     1321 attccatcat gtgctacagc accagcttta atatatgttg gatatttaat gcttggtaca
     1381 gttaaggata tagagtttga taatataact gaaggtgttc cagcttttgt tactattgct
     1441 tgtatggcat taacatatag tataggtgat ggtttaactt taggtatatt aacttatgtt
     1501 ttcgtaaata tattttataa tatatttgga gctaaaaagg cagaagacaa aaaacatgtt
     1561 tctgtagtaa tgattgttct ggcaatatta tttataataa aactttggct actataatag
     1621 gtattattta aaattttaat ttaatataaa ataaagggct gtaatttatt atcaattgtg
     1681 atgataaact acagctcttt tgtatttgtt gtatttttgt atttattgta ttatttaata
     1741 atgtctatta gttctccatt ttgtaaagtt ttaggtgtaa ttactatatt gaactctttt
     1801 tgcaaatctt ttataatatc taattctttt tttgttatta ttgagattgt gttaccactt
     1861 cgatttcctc tagcagttcg accacatcta tgcaggtatt catttttact ttttggaaaa
     1921 tccaagttaa aaacatgact tacatccaca atatctagtc cacgagcaga taaatcagtt
     1981 gtaattaaaa tctttgcttt accaagttta aatttattta ttgcattctt tctatcttct
     2041 ttttccatat ttccaaaaat tcctattgct ttgtaattat gataatttag ttttgatact
     2101 aggacttcta tatttttttc attatttaca aatacaatag ctttttttgg atttgtagct
     2161 gctaatgcct ttctaagaaa agtaaattta tcccttatct cacctaataa atatgagtga
     2221 ttgatgttag gatttatttg tgatttttcc tttgttttta ttatttcaaa ctccttcata
     2281 agtttatcac aaatttttat agtgctatca gtaagacttg cagagcatcc tataatttgt
     2341 ctatctctta acgttgttct tattatgtct tctatacaag ttatattttt tccattcaat
     2401 agattgtcca cttcatctaa gataatagtt tttatattat gtgattttag tttcttttgt
     2461 tttatcaagt ctaaaactct tccacaagag ccaattacta tgtgtggttt tactgctttt
     2521 atatttttta tttgtttttg tatattgacc tccccaatta aagctaaaga agtaacggag
     2581 agttctgcat ttttagccaa taattcaacc tggtttgtaa tctgcattac taattcatgc
     2641 gtaggtgcaa gtataagagc ttgtgtttct ctttttgatg tatcaatttt ttcaaatata
     2701 ggtaaaaggt atgctagtgt ttttcctgtt ccagtctgtg aattaatcaa taaatcctta
     2761 ttttgaatta tattccctat aacaagtgac tgaacttctg ttggagaagt tatgtcttgt
     2821 tttttgagtc catctattag agtggaactt atttttaatt gttcaaatgt attcatattt
     2881 tactccttat attttaataa ttatagtcaa ctatttttta ttatacattg tttattcaaa
     2941 tcgaactata tattctttta taattatgtg taatttgaaa gtaaatatca attatattta
     3001 tacctttata tttctgatac ctttgcattt tatagatttc taaaataaac aaataaaagt
     3061 tgtaattgtt tgatatttgt tatatattat atataacaaa tattaaaact ataatatgga
     3121 gggaaattat gttaaaagta atcaatgtat ctaaatcata taaaaataaa aaagtagtaa
     3181 gtagtgtctc atttgatgta aatgatggag agctttttgg gtttatagga cataatggag
     3241 caggtaaaac tactactatt aaagcaattg ttggaataca cgattttgaa gagggagagg
     3301 tactaataaa ttctaaatct ataaaaaaac agcctgttga atgtaaaaag gaaatggcat
     3361 atatacctga taatccagat ttatacgagt cattaactgg tatacaatac cttaatttta
     3421 tagctgacat atttgaagtt gccaaagata aaagagaaga gttaataaaa tattattcaa
     3481 ataagtttga actcaataaa gcattaggag atttaatatc ttcatattca catggtatga
     3541 aacaaaaatt agctataatt tcggctttga tacacagccc aaaaatctta attcttgatg
     3601 aaccttttgt aggtcttgac ccaaaagctt cctttatatt gaaggaaatt atgagggagt
     3661 tttgtgacaa aggtggttgt atatttttct caacacacgt tttagaagtt gctgaaaaaa
     3721 tttgtgataa gattgccata ataaaagatg gaaatataat tgcttatgga actacagaag
     3781 aagttaaggg aagtaattca cttgaaagta tctttatgga attaatagag aaataaaatg
     3841 ttttttatac aatatagtgt ctaaagtgag gaatgataaa atatgagcaa tctaagtata
     3901 ttaataaaaa ctaatataat aaatgaattt aaattaaatg cgttaaaaaa agctgatggt
     3961 agagaaaaac aaaaaataat gggaatgatg ctttcagttg ttataatagc gggtctatta
     4021 attttttatg taacaagctt aagtctctct ttagttgata tcttaaagca aataaatcaa
     4081 ctggaaatgc tactgatatt tggttttgga ttatcaacat taacaactat tgttacatca
     4141 ttatataaaa cgtcatcata tctatttcaa gcaaaagatt tagacctttt gactagttta
     4201 cctataaaag aatctactgt actagcaagt aagatattaa tgttggttgg agcaaactat
     4261 ttattttctt caatatgtat gattatacct gcagtggttt actttttaaa ttctgatgta
     4321 agtataactt atttccctta tttgatattg ctatttttag ctttaccatt attaccgata
     4381 gttgcttcat caataatttt tctatttata gggcagatat catcaagaat aaaatacaaa
     4441 aatttagtat taatcatagg tagcattata ttgatgttgc tttataccct acttatgtca
     4501 agacttaatt ctatgtcagt tgaaatgcta aagaatagtg tgtctatttc agagacaatt
     4561 agaaaagtat atcctcctat atattatttt gttgatgctc ttaaaacagg aagtatagtt
     4621 tcatttttag catttatagc catctcaata ataccatttt ttatgtttgt aactctattt
     4681 gcaaaaaaat ttaaagatat aaatgctaag atgagtgaag gatataagtc aaaaaattat
     4741 gaatttaagg gtcaaaaaac ttcaagacct tcaaaagctt tattaaaaaa agaatttaag
     4801 agatatactt cttcgtttat atacttttta aattcatctg caggtttgtt atttctaatg
     4861 gtaggtacaa ttttaatatt attatttgga gcagataaag tgggtgagtt actgaaattg
     4921 aatatagatt ttaatcttat aaaaatacaa ttattgggag tattcttctt tataatagta
     4981 atgaattgta caacatactg ttcaatttct cttgaaggaa aaaacttatg gatactgaaa
     5041 tcttctccaa tagatgaaag agaaatattc tggtcaaaaa tattgatgaa ttttttattg
     5101 aatgcaccac tatctatttt atgtctaata ttagtatcta taagattaga ctttgaaatt
     5161 cagtttatta ttgtatcaat ctgtttgatt gtaagttttt caatgtttgt agcattgatg
     5221 ggattattat caaatttatt atacccaaac cttgattgga aaaatgaggt ggctgtagta
     5281 aaaagaagtg caagtatgat agttacaatg ttagtatcat tagcttatgt aattatactt
     5341 ggaggtatat atgtattact tggaatttcg tttttaaata tatatattat tttggcaagt
     5401 atacttactt tgatattaga ttttatgata tggagaatta tttctactaa aggagtaaga
     5461 atatttaaaa atttataggt gtatttatgt caaataaaga cttatctttt ttagtcttgc
     5521 aaataatagg ttaagtagta tactatgtat agtgatatga aaaaatttag gagaaaataa
     5581 atgagaaaat tatccaaaag agaaaaagat tttattcaat atggattttt attatttttg
     5641 atatgtatta ctacttattt agtattaact actttagata taaaactaat acctaaaatt
     5701 ataaggctag taaataagac ttatatattt cttggcatat tgacaattat agtatatatg
     5761 ataattgaat ctattgtaac tcatttgata ataaatgcag ttcaaaaaac aaaagtaaaa
     5821 tttattggta ttaaaatggc tacaatggga ttttactata acttagttac tccatttgca
     5881 tctgggagtc aaccaatgca aatatatgca cttacaaaat atgatgtaag ccttagtaaa
     5941 tcagtggcta tagttactaa taaaactgta gtatttcaaa gtacagttac tgtattttgt
     6001 ggaattttaa ttttgctaaa taagtcatta ctgatggagc aagtacattc tgtgaaagtc
     6061 ttgataactt ttggaatgat tatgaatgta agtatgttgt taggtggact actaatagta
     6121 tttagtccaa aacaagtaaa aatgatagca gaagttttga ttaatttttt atctaaattt
     6181 aaaacattta aatttttaga ttcaaaacgt gatagaataa atcattatat tgatgattat
     6241 aattattcta taaaaatatt tattaaaaat gtaagaatct tagttttaag tatattactt
     6301 actgtgttac aattaatcgc atatttcagt atagtttatt gtgtgtataa agcctcaaat
     6361 ttaagaggag tttcatatgt acatataatg acattacagg tctttttata tatggctata
     6421 tcaccaattc caacaccagg aaatgttgga gctaatgagg ttacattttt tactatgttc
     6481 tccaatataa ttccaaaaga attattgggg tactctgtac tcttatatag tgggtttgta
     6541 tactatttta tattaatagt ttcaggttta tttacatttg gaacgcatta tacattaaat
     6601 tcttggaaaa aggaaaataa agtaaattct aatttagata aggttattga aaaattaaat
     6661 taataaaata attagggaaa ttctatatat aaatatggtg ttgaataagc tatattatat
     6721 tgagatattt cccttttttg attaaaatta tagaaatttg aaataataag taataaacag
     6781 aaaaagtgat attgttttga aaggagaaac tatgaaacaa gataaacaaa atgaaaaaca
     6841 aagtgagatt tctaagataa aacaaagcaa tgataataaa cttgaaatag ctcaagaatt
     6901 acatgtaagt aaaaatatag ggaatatgct tggatataga atagataaga aaaaaatgaa
     6961 tagaccaagt taatgaaaat gttgaaaatg gtacatttta aaaaatatat ataatgaaat
     7021 gttttattgt taaatttaaa cttattttaa tgggggaaaa agtcgaaaaa tatctaaaaa
     7081 gatatggata taaaaaatat taatatatat atactataaa cttgacaaaa tcaacctttt
     7141 aataactagc aaaaaatagc aaaattatat aagcgttatt taattgtcaa aaatgaaagc
     7201 taaattgcat gtcctaaaaa aaatgattga taacatttat ttgtgtgcta taattatata
     7261 gtaaaacaat aagtatattg cataatgtat gcaaatcggg aggagagacg gacatggaag
     7321 catctataca cacaattgcc agcaataatt tattgataat ttttgctatt gtaagtataa
     7381 ctggaataat ttgtagtaag cttagtgaaa taataaaggt tccagatgta gtgttatatt
     7441 tacttgtagg tattttaata ggaccatcat ttttaaaatt tatagatatt cgtggatttc
     7501 aaatagaaaa tcaactaata cttacatttg gttctgcatt tattttatat ttaggtggaa
     7561 aagaaataag tttaaaagta ttgagaaatg tgaagatatc tgtattctta ttagctactt
     7621 taggagttgt gatatctgct tttataatgc aacaagtaat aggatttact tttgggataa
     7681 gtgcaatgac tgctttacta gcaggaacta taatagcatc aacagaccca gccactcttg
     7741 tacctatatt taatcaggta aagataaagg atagggtaaa acaaactgta ataagtgaat
     7801 cagcttttaa tgatgcaaca ggagctatac taacatcagc agtgttggct gtaattttgt
     7861 caaataaatt ttcattaggt gaaaatattt atgaactggg gacaatggtt attgtcggag
     7921 ttttagttgg tttaattaca ggaatactgc ttttgaaatt agttaatgat aaaccttatg
     7981 gaatatttaa agattttgca ccaataatat ctgttatttc agttgtagtt gcatatgaat
     8041 tatctacaaa attaggtgga agtggatata tgtcttgctt tattgtaggt ataataactg
     8101 gtaacaagaa aaattttaaa atttggttaa gtcaaaaatc ttatgatgca gatttttatg
     8161 ttgctgaaac tttaggtact atttgtcgta tggcaatatt tataatattg ggtagccaag
     8221 ttaatttggc tcagttaagt aaatatttta tgccatctgt aattacagta ttagtattaa
     8281 tgtttatagc aagaccactt tgcgttttag tttgtacact tgtagacagg gaagcaaaat
     8341 ggagtaaaag tgaaatatta tttatgatgt gggtaaggga aacaggcgta ataccagcag
     8401 cactttgtgg tattatttca gcaatgaaag ttcctggata cgaagtgatt tcatctgtag
     8461 tattcatgac tatactaatt acattagtaa tacaaggaag tactacaaaa ttagtagcta
     8521 aaaaacttgg attattagaa gaagaagtga taaatataag tgaaaaagta tcaacttttt
     8581 aaagttttgc tttaaaatag tacctgttaa tggctatttt aatattgtct aatgatgatt
     8641 attgaaatag tcattttttt atgtataagt aatttacaga atttacatat tagacatatt
     8701 tattatcaaa atttgttgaa gctatgatat aattagttgt atttaaaata agaatagcaa
     8761 ataagggagg aaatttatgt ttacggttat ggatattgta cagccagata cagtagaaga
     8821 agcgtactca attttaaata aaagaaaaac taaccaagta attggtggaa gtgctttttt
     8881 aagaatgggg aaaaaaagaa taggaacagg aatagaatta tctaaattaa atttagatta
     8941 tataaaagag tatgaagatt acgttgagat tggttctatg actactttta gaacattaga
     9001 aacaagttcc ataataaaaa ataattttgg aagaataata gaagattcag ttaaaaatat
     9061 aataggagtt cagtttagaa atgtagtaac agttggtgca acagtatttt ctaaatatgg
     9121 tttttctgac ttgatagtag cattactttc attagatacg gaagtagaat tatataatat
     9181 tgggagaatt agtcttgaag agtttctaaa tagagattat gagaaagatt tacttattaa
     9241 gatatacata aagaagacaa ataagaatgc ttcttataaa tcaattagaa atgcaaagag
     9301 tgattatcca attctaaatg tatctgtatc aaaacatatg gaacaattta agttatgtgt
     9361 aggagcaaga ccgcagaaag ctacgattgc aaaacaagct agtgaatttc tatctaacaa
     9421 tgaaatcaat gaaattaata tagataaagc agtagaaata gcatcagaag aactaacttt
     9481 tggttctaac atgagagcat ctagggagta tagaaaagct atgagtaaag tacttttaaa
     9541 aagagctata atggaggtta tttaatgtta gtaaagatta atataaatgg gaagaaaaaa
     9601 agtgttgata tagaaccaga agaatatctg gttgatactt taagaaaagt tggtaattta
     9661 agtgtgaaaa gaggttgtga cacaggttgt tgtggtttat gtacagtttt aattgacaag
     9721 aaacctacat tatcttgtgc aacactgaca ttgagagctt tagataaaga aataactaca
     9781 attgaaggtt tagaaaatga agttaaagaa tttagtgaag ttttggtaaa agaaggagct
     9841 gagcaatgtg gtttctgttc tcctggcttt atacttactg tacttgcaat gaaggatgag
     9901 cttgaaaatc ctacagatga tgaaataaag cattatctta caggaaatct atgtagatgt
     9961 acagggtata tgggacagtt aagagctatc aaaacttatc tggaggtaaa atagaacatg
    10021 aatatagttg gaaaaggaat caagaaaata gatggaatga gtatcacaac aggaaagcct
    10081 gtatatacag atgatttatc agcaaaagat gctttggtgg taaagatact tagaagtcct
    10141 cacgcttatg caaaaataaa agatatagat acatcaaagg cagaaatggt tgatggtgtt
    10201 gaatgtgttt taacatataa agatgtacca aaatctcgat ttacacttgc tggtcaaaca
    10261 tatccagagc catctccata tgatagatta attcttgaag atgttgtaag atatgtaggt
    10321 gacgaagtag ctatagtggc agctatagat gaaaaaactg caattaaagc aatgaatctt
    10381 atcaaagtaa agtatgaagt acttacacct gttttggatt ttgaagaggc aataggaaat
    10441 aaaactatgg tacatgatga agatagacat tgtaactttg atataggtat gcaaagagaa
    10501 aaaaatatag tatcccatca tgattataca aaaggtgatg tagaaaaagt attaagtaat
    10561 tgtgatgtag tgattgaaga aacttattat actcaagctc aagcacatgc aatgatggag
    10621 acgtataggg catacaatta tttagaccat atgggaagat tggttgtagt aagttcaact
    10681 caaataccat ttcatgtaaa aagacattta tctcgtgcac tagaaatacc agctagcaaa
    10741 attagggtta taaaacctag aattggtggc ggatttggtg gtaaacaaac tgcatgtgtt
    10801 gagatttttt ctgcaattgt tactttaaaa acagggaaac cagctaaaat aatttatgat
    10861 agaaaagaaa cttttaattg ttcaacaagt agacatgcaa tgagattaaa agttagacta
    10921 ggtgctacaa atgatggcat aataaaggca atagatataa aagcactttc tgatacagga
    10981 gcatatggag agcatgcttc tacaactatt ggtttggttg gagaaaaaac tttaccaatg
    11041 tataataaag ttgaagcaac aagatttatt gcagatgtgg tatatactaa taagatgcca
    11101 gcaggagcac ttagagggta tggagcatca caaggatgtt ttgctgttga atcaactata
    11161 aatatgcttg ctaataaatt aaaaatggac ccaacagatt taaggttaaa aaatgtggta
    11221 acagaaggtg aaactacatt tgcatatggt aaaactttaa atagtgtcga tttaataaaa
    11281 tgtataaata aaggcaaaga acttattgga tggaatgaaa aatatccttg taaacatctt
    11341 gataatggaa aaattagaag tgtgggtatg gcaattacta tgcaaggttc tggtatacaa
    11401 ggtcttgata agtcttcagc tgaaataaaa ttgaatgact gtggagatta tactcttatg
    11461 ataggttcta ctgatatggg tacaggaagt gatacaattt tagctcaaat ggctgctgag
    11521 gttcttgata caagcattga aaatataaca gttatatcag ctgatactga cttagttcca
    11581 tatgacccag gttcatatgc ttcaagtact acttatgtaa caggtatggc agtagttaag
    11641 gcagctcaag acttaagaga aaaaataatt tctgctggag caactaaact aggtgttgag
    11701 aaggatgaag tagaatttga tggtataaaa ttaactagta aaaaaggtag cactttatta
    11761 ttcgatatag cagttgattc tacaattggt ccagatacta atcaattaat aggtcttgct
    11821 tctcatggta gcccagtatc tcctccacct tttatagcag gttttgcaga aactgaaatt
    11881 gacacagaaa ctggaaaagt tgatttagta aattatgtag ctgtagtaga ttgtggaacg
    11941 gttataaata aaaatctagc taagatacaa gttgaaggtg gaattgttca agggattgga
    12001 atggcattat ttgaagaagt tagatacaca gaaaaaggaa gcatggacac aaatacattt
    12061 atgcaataca agattccagc tagatgtgat attggaaatg ttaaagtaga ttttgttgaa
    12121 acttatgaac caactggacc atttggtgct aaatctgttg gagaagttgt tataaataca
    12181 cctttaccag caatacaaga agctgtgttt aatggaattg gtgtaagaat aaatacactc
    12241 cctattacac ctgaaaaagt ttttatggaa atgaataaat aattatttat gaaaatttag
    12301 actagtttta catgttaaac aaccagttat gtcatacctg ttgaaagata tttaataagt
    12361 agttattata atattatgaa ttttacttat aaaatacaaa attaaataag gggatgatgt
    12421 tttggctggt aatctaaata atatgagagc agtaaataat tttagaggag ataagaacat
    12481 tttagaatgt ttagtcagct ttgagggtcg ttcaataagt cagagaaaag taagggtatt
    12541 ttttaaagaa aaacaaaatc aaatagaaat tgattttgca gaagaggaaa tttctaaatt
    12601 ggttgaaaat gttgttttaa atacatcata tcaagaaatg ttatatgatg aaatagagaa
    12661 acaactggaa attgattgta taggtacttg gatgatatta tctaaattaa aagatggtag
    12721 tagagttcac tgattttaaa ataaattatt agagcctaat tttaaggctc ttttttgctg
    12781 tttttaatta acaatagaaa atttatcttt agtttgtata taattttaat atcatatatt
    12841 ctatatatat aaaattgaat ttgtatgtat tatattgtat aatataaaat gaattgggaa
    12901 aatagttcgc taaaataatt tgtttttata aaattactgt ttaagtttat agattttgta
    12961 taaaataaag ttatgttatt aattttttta aaaataaaac ttttactagg agacagatat
    13021 gagaaaaaat agtattaata tagcactaac tgcagcaatt acagcaatct atgcagtttt
    13081 aacattatca ttgggattta taagttatgg accaatacaa tttagggtag cagagattat
    13141 gatgcttttg gcatttttag ataaaggata tatagtaggt cttacattag gttgtttttt
    13201 agcaaatgta ataggaccat atggtgtacc tgatataatt tttggaacat tagccacatt
    13261 tataagtgca agtatgattt atattactag aaagttaggt aaacaaaata aaagtacttt
    13321 agttatagct tctttatggc caactgttat aaattcgatt gtggttggtc taatgttaaa
    13381 tgtattcttt gggcttccat taattctatc tatgatacag gtaggttttg gagaatttgt
    13441 agtagtaaca attgtaggag taccattttt ctgcttttta atgaaaaaat ataaaaatgt
    13501 cattaatatt aaattttaaa tagtgtatag taatttaatt aattgagagt attattagtg
    13561 aaaagaggtg tttatttgtc gaaggtaaaa agattgactg atgtttggat atatattaat
    13621 gataagcaaa agtttacaat aaaagagttg tcagaggaat ttaatctttc agctaaaaca
    13681 atacaacgat atttaaaaga attaaataaa atgggacttc caattcaagc agaacaaggt
    13741 agaaatggag gttatagggt gctaaataat agctatatac ctcctgttat atttacagaa
    13801 aaagaagtta tgattatact atttgcactt aagtcacttc agatttataa ttataagtta
    13861 atggaaatag aaattaattc tataatgaga aaagtaagtt atgaacgtaa aagcagtata
    13921 aaagtaggta tagaaaatat taaaagatac attggctttg tagctaatga tactaatgat
    13981 ggagatttta agagtagtaa tgtaactgag ttttttagag cttcttcaga atctctaatt
    14041 ttaaatatta agtataagtg tggtaatcag attttggaaa aaaacgtatg ccctataggt
    14101 atatatttaa ataagggagc atggttttca ccagcatatg attgtaaaag tgataaaata
    14161 atattagttc atatagataa tataattgat ataaaaagaa caggagaaag taaaaaaata
    14221 catataaact tggaagaatg gttacatgaa gtatataaca atttatatgg aaatagttca
    14281 actactaaaa aatttggtga aattatttat ctaaatgtat tattaactaa agaaggtgtt
    14341 tctaaaataa aggacagttc ttggaattta gatatggagc taaatgaaga tggtagtgga
    14401 ataattagta cattcataaa ggttgaagat atagattgtt atgcttcgat tttatttttt
    14461 attggaaata atgctaaggt tatagagcca aaatttttga ataagctact ttatgataag
    14521 gccaatgagt taagatattt ttatgaagaa aatatggtat aatatttaga aatgttgaaa
    14581 ttaaataatt attaaggaga tatacgttat aatggaaaat tttaataaga atgctaaaat
    14641 aattggtatt ggagctgaag gtattaatat aataaatgaa gtagaagaaa aaataaaagc
    14701 aaatatggat atagaaaaaa taaacataaa tcaagagatt gaaaaagaat atgttagaag
    14761 tcttttagat ggtgtagata tattattttt gatatattca tctgaagata aacatattag
    14821 agatattata aaagctgttt catatatgtc aaacgaaaga agagttctat ctataggaat
    14881 ggattgttca gagaaggaaa ataaagaaga tttagagctt gggagagagt ttaaaatcaa
    14941 taatgatagt atatttaaat ttgttgattt aatgaatatc atggtagagt ctatttctga
    15001 ttcttgcatg ataaatatag atattactga tttaaaagaa gctattgtag gagataaagg
    15061 aattaagtat tcttttgaag agtttgaaga tacaaagtca tatagcgaga tagctgacat
    15121 tttatttgac aggatggaat atattggtga ggaatttata agtaagaaag gaattgtatt
    15181 tgttgaagga agtccagaat tttctataat ggaattgaat gatttaataa gtaatattca
    15241 gagcaaggta gaagaaagct atgaagtaat attttcttta tatataaagg aaaatttaaa
    15301 tggaaatatt agagtaggct tattgtataa ttagtatatt ttagatatta aggagagtgt
    15361 atatgtctga aaatataaga ggtacagagt attggttaat ggaagaattt ttttatcagg
    15421 aaacagacac accacagatt tttagagaag aaagcataat tgcacttgga tttgatataa
    15481 aaataaattt aaaaaaagta ttcagtatgg ggaaaaaatc agaaaagtat attaatgaga
    15541 attgtaatga taaagatttt ataaaaaagt ttatgtcgat taaaaaagga gattattttt
    15601 tatataaagc atatcaaaat atagaagaaa aagttaaatg taatgtgtct attggcatag
    15661 ttgaagaaga ttttgaaaat ggatatgaat taagtcatat tttagggcat acactaccag
    15721 taaaatggat gcataatttt gatacagttt caaattgtaa agtatataca agtgaatttt
    15781 ataaattaaa taataatgat attagttcat atttagaaat tattaagtca caagataaga
    15841 aattattgag aaaaagaata gaagaaagtg aaaataataa atggtattta aaaaactatt
    15901 attataaaaa tgtagataag tgtgtagatg atgaagaatt atttattcag cccattaatc
    15961 tagaacaatt agaaagccta aaaaatataa agacagatga ttatatttta ttgtataata
    16021 gcgagaaagt aatttgtgaa aatgaccata caatgaagag tctatttggc gtatgtcaag
    16081 ttatggaagg gttcgataaa gagaaagtaa gtgctttgga gggtggatat ttttttcctg
    16141 ttagatggat agagtatgaa aaggagaata tagacggaaa tgcatgggtt atatttgaaa
    16201 ataatagtat agttgaaaag tatgtaaaaa gatttactaa taaaatgcca ttaaatacta
    16261 tactttatgg accaccagga actggtaaaa catacaatac aaaacagatg gtttacaatc
    16321 tagtaagtga aaccagtcta agaaacagat actatacagg ttacttagat tataaaaata
    16381 atgtagaatt ttgtacattt catcaatcat atggatatga ggaatttata gagggcctta
    16441 agtctgatgg tgaaggcaat tttaagccag aagatgggat attaaaggat atatctatag
    16501 aagcatgtta taatgcattg aaatttgaaa aaaagatgag ctttgagttg gaaaaagata
    16561 gcttgacttt agaaactata aaagacagga aaaagaaatt agtattagaa aatatagaat
    16621 atagtgagag ttttaatttt gaagaatcag aaaactatgt tttaataata gatgaaatta
    16681 atagagggaa tgtatctaaa atatttggtg agctaataac attattggaa gatgataaaa
    16741 gacttactaa atcaaatcaa actattgtca aactaccata ttcaaaggaa aaattttctc
    16801 tacctccaaa tttgtatata gttggaacta tgaacacatc agataaatca atagcacttt
    16861 tagatatagc tttaagaaga aggtttaatt ttgaagaaat tatgccagat tatgatttat
    16921 tgtctattgt agatggtata gatattagaa aaatgctata tacaatcaat aaaaggatag
    16981 agtttttata tgatagagac catgttattg gacaagctta tctacttgct gtagaaaata
    17041 ttaatgatat agtagtagta tttagaagta aaataatacc acttcttcaa gagtattttt
    17101 attatgattc agaaaaagta ggtttgattt taggaggaat tggaagaaat gaaaaagata
    17161 aatacattgt ttataaagaa aaacttatag cttctgagtt atttaaaaat aataatgcct
    17221 caataatgga gagtaaagtt aactattgta taaaacaaaa catatctagt gaggagctaa
    17281 aaaatatata tgagtaaaaa tatatatgtt aaggaaacct atgaatggat aaggataggt
    17341 aatggtgaaa atgagcttac agaaattgaa tatgaaaaat tgcttaagta tctagagaac
    17401 aataatgatg tattaaaaag taatataata gatattaaat acaaaaaact tagatttata
    17461 aactatgtag gcatcatatg ttttgaaaat gtaatacttg aaatacttcc taaattgtca
    17521 ttaagtgata atcttgtaaa agatagagag atactattac agatgctttc tatatgtaat
    17581 aaaattccaa ttacaatgaa tgaaaaaata agattgagtt tgaaaaatta taatctctta
    17641 aatttttttg ttatgtattt cattgagagt atgcaaacac agatgaaaaa aggtatttat
    17701 tttgaatata taaataaaat agagaactta aatgttatga ggggtaaaat attattaagt
    17761 acatatgcaa aagaaaaagg catttctcca atgaaaataa gatgtgaata tgatgagtat
    17821 agtgaaaata atttcttgaa tcaagttctt aaaaaagcat gtatatctat tttatgtaga
    17881 ataaatgaca attcaattca aggcaagatt aaaaaaattt taagctattt tcaaaatgta
    17941 gatttaattt atatagatag aaaaaaactg ttggattata aattttataa aaacaatgat
    18001 agatttaaag attgttattt actagctaga cttctacttt taaatttgtc tatggataat
    18061 agtcaaaata atcaagaggc attttctata ttatttgaaa taaatacttt gtatgaagaa
    18121 tatataggaa ttttaatcaa aagtatatgg gacaattcat ttagagaaac atatatacaa
    18181 gataagagta aatttctttt gaaaaatgaa caaactggta agaaaaactt taatttaaga
    18241 ccggatatag ttttatatga cttaaaaaat gaatatgaaa ttataattga cactaaatgg
    18301 aaagctattg aagtagattc aaatgttttt tataggtcaa gtgatatata ccagatgtat
    18361 gcatatataa cagcatatga aaatgcaaaa agatgtatat tattatatcc ttgtattcaa
    18421 aaagataaga attatagttc ctggaaatta tcagaatcat ttaagggtaa gtttatagaa
    18481 gcaaaaactg tgaggttaga tgatata
//
LOCUS       DAEHWM010000087        18225 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.088, whole genome shotgun sequence.
ACCESSION   DAEHWM010000087 DAEHWM010000000
VERSION     DAEHWM010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18225)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18225)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18225
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.088"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            656..1408
                     /locus_tag="KNP36_002905"
     CDS             656..1408
                     /locus_tag="KNP36_002905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874764.1"
                     /translation="MLKVNQLCKSYKTGSKTYPVLKNISFEINKGEFVAIMGSSGSGK
                     TTLLNCISCFIPIDNGEIILGNNNIRNLKEKELSEVRNQQLGFVFQDFMLFDGLSVFE
                     NICVPQIIKGSQVLQMENRAINLCELFGIEHIRKKYPAEISGGEKQRTAVARALMNNP
                     DLILADEPTGNLDSKSCRTVIESFLKAKQELDATILMVTHDSFAASFCDRVIVLKDGI
                     IYKEVVKSNSRHKFLDELLEVLKEMGGAQDDN"
     gene            1398..3509
                     /locus_tag="KNP36_002906"
     CDS             1398..3509
                     /locus_tag="KNP36_002906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874765.1"
                     /translation="MTINKLYSKLRAYNWKNYTTLFFCIILSVVLVTSYALIYFSPTI
                     QNILPTGGDSRKQATMIFSVAILGCAVFTTYASSLFLKFKSKEIGIFMALGTDKKKLK
                     KLLFSEILLISIVCCFLGLILSIPVSFGIWKIFQLVIIDTREMTYHFGTQGFIYGFIF
                     SVFVTLCIFILSVKFINRTNIIDILNDQRISEPIQDVKDWYGILGIIFIILGIFLGYL
                     VPSLTINKLNYKLPSIWSFTYLLSLIGIYMIMTYIVVHAKRGKHPEKYYKNIISTSMM
                     RFMGRQTVKNMCVISFLIAGALFAVFYVPNMVTGIYDTLKNNPIDYTFTYNQRDKQVS
                     KKDIEQLADKHNIKIQNYMEIPSIELIVDGVESIYHKDGTIEKVYMKKSSYDMFFNSK
                     DFSKLIGKPITIKNGEYLAVVNKGNENQDYKYTKFISSPVTEKEIPFRYAGKIIFNGS
                     FFQNRSMNAYVLNEEDYKSFTKDLSIKNYNNSILFNVDKDTYAFANDLKKEIIKRTSK
                     EMGMFSGYDEYVKKRYESTGRKYFMDEEYPSGEGHLKLDPNNNQLYLNWKYYPNFKIL
                     QSQDMIKNMAVFLMLFIYVAIICFTAVGIIAYTRGVTIAINHKQVFMDLNRLGANNDY
                     IKFCIRNQLKKVFSYPLIAGSFLIYLFNFMIMLNNDGRIVNSEVNALLINLGFIGICG
                     VYMYLIYLLTYKKFKKIIGIL"
     gene            3893..4603
                     /locus_tag="KNP36_002907"
     CDS             3893..4603
                     /locus_tag="KNP36_002907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874766.1"
                     /translation="MTSICICDDEKQQRNMLNKIITREMDLWGYPYQIKEYSNGESLV
                     YNLEHENYYIDIIFLDIELGKSNGVDIAKTIRKHSKDTIIIFVTGFSDYVFHGYDVGA
                     LNYILKPYKTEKICKVLKEALKKLEQWKENFITVQIGTNLCKINTKDILYFKSELRKL
                     TVVTFDKTLEYYGKLNDMETVLPSNFIRTHQRYIVNLNHVDSITQTYAKVQNEKIPIS
                     RKKYQEVVGKFTRYMLES"
     gene            5126..6463
                     /locus_tag="KNP36_002908"
     CDS             5126..6463
                     /locus_tag="KNP36_002908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0874767.1"
                     /translation="MGTYSLISTSINFILILINIFIAFFLYKLTSYFIDFRNHWIFKI
                     ILILGYSIISQMIIWLSDPINILFTLFGYFILLIICSKSKLIPIISVVMILYPIIIGL
                     NFLFINNPIYEELIHSKEYILILSIVQIISALIKLLFWFLIHIFLKNRLVNIKQYLSN
                     KIWIFIDMVCISSFLSILIAIILPPTNLIPMGSNKNIILGNLPYGTYLIILSAILANI
                     GVILLLQPLIENVKMKIEKQANHLKEKYYNLLENQQIQIRKMRHDMNNHFQMIESYLE
                     IEDIAGAKKYFNQLKIGIGTLSGKQFCKNQALNSILNLRHTSLEENGVDVHFNIDIDN
                     HLGIEPIDLCTIFSNSLDNAIEASLKIPDLSNRKVVLKARCEKEYFSYLLTNNKVNPI
                     NRKQELFISDKKDSNSHGYGIENIREIVNKYNGKLDISYTESEFSLFLYIRLF"
     gene            complement(6799..7368)
                     /locus_tag="KNP36_002909"
     CDS             complement(6799..7368)
                     /locus_tag="KNP36_002909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrpB family protein"
                     /protein_id="HBF0874768.1"
                     /translation="MKKKLEDMTLEELWNLFPIFLTTHKECWKNWFKEEQYRLTGILP
                     MQKIVRISHIGSTSVSTIYAKPIVDILIEIIPDYNMKDIKDLIESNGYICMSESSSRL
                     SLNKGYTVEGFEERVFHLHIRYVGDNDELFFRDYLIDHPDVAKEYEKLKLDLWKKYEH
                     NRDAYTDSKLDFVREFTEKAKVLYSNRYN"
     gene            7738..8343
                     /locus_tag="KNP36_002910"
     CDS             7738..8343
                     /locus_tag="KNP36_002910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="urea carboxylase-associated family protein"
                     /protein_id="HBF0874769.1"
                     /translation="MTNWNLWRTLNMEYIINPCSGIKIKITRGQKIEIVDIEGGQVVD
                     FFAEMKDDSTEFISPGVTIDCNESLRLQVGNLIYSNKYRPMFKILYDDVREHDLLHPC
                     CRPEMYDFFYHNGENHPNCFDNINRTLGTSHQIIHPINLFMYTKVNTDGSIEVCEPLS
                     KANDKIILEALENMTLGIAACSVSESSCNSRKCTSIKILVD"
     gene            complement(9022..9924)
                     /locus_tag="KNP36_002911"
     CDS             complement(9022..9924)
                     /locus_tag="KNP36_002911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895617.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HBF0874770.1"
                     /translation="MLPQDYYGLIVILGVILGVMGAFYNWFTLYVQSLYKKIPKIGTF
                     GKLLIPFIMAGILGLVMPDVLGSGHNLVEELTSHKYIFGMVVLIFVIRFIFSAVSFGS
                     GAPGGIFFPLLVLGAFIGGIFGMVGVKVFGMNPDYVNNFVLLAMAGYFTAIVRAPLTG
                     IILIFEMTGSVSQMLSLSVISIVAYIVATLMKSKPIYESLLERLLEKNGEPVHKERGE
                     KILDQFSVMFGSPVANKAIQDVQWPENCLLVAIQRGGEEIIPRGKTILRPSDVIVTMT
                     DERDSGAVYDKMENLCKEHTAHIF"
     gene            complement(10051..10170)
                     /locus_tag="KNP36_002912"
                     /pseudo
     CDS             complement(10051..10170)
                     /locus_tag="KNP36_002912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(10716..11378)
                     /locus_tag="KNP36_002913"
                     /pseudo
     CDS             complement(10716..11378)
                     /locus_tag="KNP36_002913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016440163.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
     gene            complement(11538..12074)
                     /locus_tag="KNP36_002914"
     CDS             complement(11538..12074)
                     /locus_tag="KNP36_002914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438861.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GrpB family protein"
                     /protein_id="HBF0874771.1"
                     /translation="MIGLKCGMVKLLEHQMIWDKSAKDVIILLKSIWDKTAIDIQHIG
                     STSIPSISAKPIIDIVVGVASLEEAKLYLERLEQCGIVFRGQDVPKQLLFAMGDFEKN
                     TRTHHIHVVEWNSVAWNNYINFRDYLNTFTDKAKLYDSHKQKLALQFEDNRKIYTQRK
                     QELINILLEEARLWRINT"
     gene            complement(12147..12560)
                     /locus_tag="KNP36_002915"
     CDS             complement(12147..12560)
                     /locus_tag="KNP36_002915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003507530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBF0874772.1"
                     /translation="MKMPKESIDTIMFAPCGMNCMVCYKHCYHKKPCAGCLNGDTGKP
                     EHCRKCKIKDCVCQKGLFYCFECFNFPCKLIKNLEKSYNKRYQASLMENSKFVQQYGL
                     EKFMQKQKERYTCSKCGGIISIHDRECSECQEKVK"
     gene            13026..13580
                     /locus_tag="KNP36_002916"
     CDS             13026..13580
                     /locus_tag="KNP36_002916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="HBF0874773.1"
                     /translation="MDEKILELLQEMQGNISNMQGSISGIEGTISDMQSNINGIEDTI
                     SGMQGTISDMQGSISSMNGTISDMQGSISSMDGTINSMQDSITDMQVEIKEVNSRLDN
                     MEPDIKDLKTGQVETSSRLDTIQSDVTEIKSDVKINRNTLDTVIKHTSSLVKDTSDIK
                     NDLNNIEIVTSKNSNDIAKLKSVK"
     gene            complement(14188..14367)
                     /locus_tag="KNP36_002917"
     CDS             complement(14188..14367)
                     /locus_tag="KNP36_002917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HBF0874774.1"
                     /translation="MLQTGKQGADKKYLDNMFFVKGYVEELLFLDNSYDIVFSCIVFH
                     HCTNVQNIFCIFWKW"
     gene            complement(14593..15126)
                     /locus_tag="KNP36_002918"
     CDS             complement(14593..15126)
                     /locus_tag="KNP36_002918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HBF0874775.1"
                     /translation="MQYISYYHSPIGNILLASDNIGLTGLWFENQKYYAYNLDQEHQE
                     KELPIFEQTKKWLDIYFSGKEPNFTPSLHMVGTPFQTTVWKILQQIPYGKTITYGEIA
                     YKVAQQKGISKMSAQAIGGAVGHNGISIIIPCHRVVGTNGSLTGYAGGIDRKIKLLSL
                     EKVSVQHYFIPKKGSAL"
     gene            complement(16874..17446)
                     /locus_tag="KNP36_002919"
     CDS             complement(16874..17446)
                     /locus_tag="KNP36_002919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBF0874776.1"
                     /translation="MWIYQKTLEHPVNIRQADPRMAKYIMTQLGGPNGELAAATRYLQ
                     QRYTMPTGKSRALLTDIGTEEMAHVEIISSVLYQLIGNCTPEELKAAGLGSNYANFGH
                     GLQPVDSNGVNFTTSYINVFGDSVTDLHEDMAAEQKALATYYQLINLTDDPDLKDILR
                     FLGEREVVHYQRFGEALMDVYEFTECKHQF"
     gene            complement(17508..17771)
                     /locus_tag="KNP36_002920"
     CDS             complement(17508..17771)
                     /locus_tag="KNP36_002920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein CotJB"
                     /protein_id="HBF0874777.1"
                     /translation="MSLNRRELLERISEYQFACIELNLYLDNNPRDKKALDSYNRYCD
                     KFTQAVCDYESKYGALTNFGYESSEYPWSWISEPWPWDKSFYK"
     gene            complement(17771..17992)
                     /locus_tag="KNP36_002921"
     CDS             complement(17771..17992)
                     /locus_tag="KNP36_002921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat associated protein CotJA"
                     /protein_id="HBF0874778.1"
                     /translation="MGYLKEDKQDYCCEFARPYINRQIYDDTYNPKTALKRGTLFPEL
                     DLIESNNYNDWLYANPKNRVRAKKGGNMY"
BASE COUNT         6540 a         2898 c         2206 g         6581 t
ORIGIN      
        1 acctttatta ttacaacatt ttattatttt aacttcttta ctataatata gtaatatttt
       61 aatatctcaa aatcatatca atcacttttc agcatagtct aaaatacttc cactttctaa
      121 aattatctat catacctata ctaataatac tttttaacct ttttattata catttcaatt
      181 gtttctaaca acctatttat ttccaaaact ccaatatatt ttctcaatta cattgtgtta
      241 atagccccta aatcctttca aattatttac aatacattcc attaaataat cttactgctc
      301 tataattctt tttttctttt taaccctact atacattatt tacatcattt ttttcaatac
      361 aacattcgtt attctataac ctttttactt ttactatata cttcttttct aattacacct
      421 tcaatgttcc acatcatatt actttagcac aacaattaat acctaaaaat aaccctctaa
      481 atcctccaat aatataatca atttaactat aataataacc tctcacacta tccaaacaat
      541 atattttcaa acattacaaa aaaacatcca actattacaa tatagctcat atccctcctc
      601 ccctttcaaa tgctatcatt gacttacaag ataaatgaaa gtgaggatga tatatatgct
      661 taaagtaaac caattatgta aatcatataa aacaggcagt aaaacatatc ctgtattaaa
      721 aaatatttct tttgaaatca acaaaggaga atttgtcgca atcatgggtt catcaggaag
      781 tggaaaaact actcttttaa attgtatttc atgttttatc ccaattgata atggggaaat
      841 aattcttgga aataataata taagaaattt aaaagaaaag gaactttcag aagttagaaa
      901 tcaacaacta ggatttgtat tccaagactt catgctattt gatggtctta gtgtctttga
      961 aaatatatgt gttccacaaa ttatcaaagg tagtcaagtc ttacaaatgg aaaaccgtgc
     1021 aattaatcta tgtgagctat ttggtattga acatatcaga aaaaaatacc ctgccgaaat
     1081 atctggtgga gaaaaacagc gtacagcagt agcaagagca ctcatgaaca acccagattt
     1141 aatattagca gatgaaccaa ctggtaacct tgatagtaag tcttgtcgta cagtcattga
     1201 atcattttta aaagcaaagc aagaattaga tgctactata ctcatggtta cacacgatag
     1261 ctttgcagca agcttctgtg accgagttat tgtgcttaaa gatggaataa tttataaaga
     1321 agttgtaaaa tcaaattcaa gacataaatt cctagatgaa ttactagaag ttttaaaaga
     1381 aatgggaggc gctcaagatg acaattaata aattatacag taaacttcga gcctataatt
     1441 ggaagaacta tacaacttta ttcttttgta taatactttc tgtggtatta gtaacttcat
     1501 atgctctaat ttattttagc ccaacaatac aaaacatact tccaactggt ggagatagca
     1561 gaaaacaggc tacaatgata ttctcagttg ctatattagg atgcgctgtc tttactacat
     1621 acgcttcttc cctcttttta aaatttaaaa gcaaggaaat tggtattttc atggctctag
     1681 gaacagataa gaagaaatta aaaaaacttc tattttcaga gatattgtta atttcaatag
     1741 tatgctgttt tttaggtctt atattaagta ttcctgtatc ttttggtata tggaaaatat
     1801 ttcaattagt gattattgat accagagaaa tgacatatca ttttggaact caaggattca
     1861 tatatggatt tatatttagt gtatttgtga cattatgcat atttatactt tctgtaaaat
     1921 ttattaatcg tacaaatata attgatatat taaatgacca gagaatatct gaaccaatac
     1981 aggatgtaaa ggactggtat ggtatattag gtataatttt tattatactc ggtatttttc
     2041 taggatatct cgtaccttca ctaactataa acaaattaaa ttataaacta ccatctatat
     2101 ggagctttac ttatctactc tctcttattg gaatatatat gattatgaca tacatagttg
     2161 tacatgctaa aagaggaaaa catccagaga aatactataa aaacatcata tcaactagca
     2221 tgatgagatt tatgggaaga caaacagtaa aaaacatgtg tgttatttca tttttgattg
     2281 caggagcatt atttgctgta ttctatgttc ctaatatggt tacaggtatc tatgatactc
     2341 ttaaaaataa ccctatagat tatactttta cctacaatca aagagataaa caggtatcaa
     2401 aaaaagatat tgaacaatta gcagataaac acaatataaa aattcaaaac tatatggaaa
     2461 ttccttctat agaattaatt gttgatggtg tagaatcaat atatcataaa gatggaacta
     2521 tcgaaaaggt atatatgaaa aaaagctcct atgatatgtt ctttaattcc aaagattttt
     2581 ccaagctaat tggcaaacca ataactataa aaaatggtga atatcttgct gttgtaaata
     2641 aaggaaatga aaatcaagat tataaatata ccaaatttat atcaagccca gtcacagaaa
     2701 aagaaatccc ctttagatat gctggaaaaa taatatttaa tggttctttt tttcaaaata
     2761 gaagtatgaa cgcctatgtc cttaatgagg aggattataa atcatttact aaagatttat
     2821 ccataaaaaa ttacaataat tctatactat ttaatgtaga taaagatacc tatgcttttg
     2881 ccaatgactt aaagaaagaa attataaaaa gaacatctaa ggaaatgggc atgttcagtg
     2941 gttatgatga atacgtaaaa aaacgttatg aatcaactgg aagaaaatat tttatggatg
     3001 aagaatatcc aagtggtgaa ggtcatttaa aactagaccc aaacaacaat cagttgtatc
     3061 ttaattggaa atactatcct aactttaaaa ttttacaaag ccaagatatg ataaaaaaca
     3121 tggcagtctt cttaatgtta ttcatatatg tggcaatcat atgttttaca gcagtaggaa
     3181 tcattgcata tacaaggggt gttactatag ctataaatca caagcaggtc tttatggatt
     3241 taaatcgatt aggagcaaac aatgattata taaagttctg tattagaaat caattaaaga
     3301 aagtattttc ataccctctt attgcaggaa gttttttaat ttatctgttt aattttatga
     3361 ttatgttaaa taatgatggt agaatcgtca atagtgaggt caatgctctt ttgataaact
     3421 taggttttat agggatttgt ggggtttata tgtaccttat atatctatta acttataaga
     3481 aattcaaaaa aattattggt attttataat aaaaaaggtt attagatttt taaagtaata
     3541 aaatcattgg tgttttataa taaaaaaggt tattagattt ttaaagtaat aaaatcattg
     3601 gtgttttata ataagaaagg ttattagatt tttaaagtaa taaaatcatt actttttata
     3661 ataataaaag catttgtatt ttataataag aaagattgtt agatttttta ataagaaaat
     3721 cattagcact tcagaataag tttaatagaa tagttttaag tgtaagtata ctaatataaa
     3781 aaattttatt ttgctatctg gatataattg ttatttcatt ttatatatct aggtagcaaa
     3841 atatattata tacttaacta tataaatata aaacttgaaa ggagataaaa aattgacttc
     3901 gatttgtatt tgtgatgatg aaaaacaaca aagaaacatg ctgaataaaa tcattacaag
     3961 agaaatggat ttgtggggct acccctacca aataaaagaa tattcaaatg gagaaagtct
     4021 agtatacaat ctagaacacg aaaattatta catagatatt atttttttag atattgaact
     4081 tggaaaaagt aatggcgttg acatagcaaa aactatacga aaacattcaa aagatactat
     4141 aatcatcttt gtcacaggtt tttctgacta tgtatttcat ggatatgatg taggagcttt
     4201 gaactacatc ttaaaacctt ataaaactga aaaaatatgt aaagtattaa aagaagcact
     4261 aaaaaaatta gaacaatgga aagaaaactt tattacagtt cagattggaa ctaatctttg
     4321 taaaattaat acaaaagata tcctctactt taaaagtgag ctaagaaaat taactgtagt
     4381 tacctttgat aaaacattag aatactacgg aaaattaaat gatatggaaa ctgttcttcc
     4441 ctctaatttt atacgtacgc atcaaaggta tattgtcaat ctaaaccatg tagatagtat
     4501 aactcaaact tatgccaaag ttcagaatga aaaaattcct ataagccgta aaaaatatca
     4561 agaggttgta ggaaaattta caaggtatat gttagaatct taatttttga agttcaatct
     4621 ctagaatttt atttttgaaa cttaactttt taaagcttag tttttagagt tttgtttttt
     4681 caaatttaat tttttgaagc ttaatttcta gaatttcaat ctttcaaaat ttaatttttt
     4741 gaagcttagt ttttagagtt tttttcaaac ttaatttttt aaagctcagt ttctagaatt
     4801 tcaatctttc aaaatttaat tttttgaagc ttagttttta gagttttttc aaacttaatt
     4861 ttttaaagct cagtttctag aatttcaatc tttcaaaatt caattttttg aagcttagtt
     4921 tttagagttt ttttcaaatt taattttttg aaacttaatt tttaaaattt caatctttta
     4981 aaactcaatt ttttgaagct taatttctag aattttattt ttcaaaatca attctttgaa
     5041 atctaatttc cagaatttta atttttaaga tttaattttt taaaacttag tttccagaat
     5101 cttaattaat agaaaggtat attaaatggg cacttattct ttaatctcta caagcataaa
     5161 ttttattcta atattaatca atattttcat agcctttttt ctttataagt tgacttccta
     5221 ttttatagac tttaggaatc attggatttt caaaatcata ttgattttgg gctactctat
     5281 tattagtcaa atgataatat ggctttccga ccccataaat attttgttta cactattcgg
     5341 atattttata ctacttataa tatgtagcaa aagcaaatta attcctataa tatcagttgt
     5401 catgatactt tatcctatta taattgggct taattttctt tttataaaca accctatata
     5461 tgaggaactt atacactcaa aagagtatat tttaatactt tcaatagtcc agataatttc
     5521 tgctctaatt aaattattat tttggttttt aatacatatt ttcctaaaga atagattggt
     5581 caatataaaa caatacttat caaataaaat atggattttt attgatatgg tatgtatatc
     5641 ttcattttta tcaatattaa ttgctattat tctgccacct actaatttaa tccctatggg
     5701 tagtaataag aatattatct taggcaactt accttatggc acttatctaa tcatcttgtc
     5761 agcaattctg gcaaatatcg gtgtgatact tcttttacag ccattgattg aaaatgtaaa
     5821 gatgaagata gaaaaacaag caaatcacct aaaagaaaaa tactataact tactagaaaa
     5881 tcaacaaatt caaatacgca aaatgcgaca tgatatgaat aatcactttc aaatgattga
     5941 atcgtattta gaaattgaag atattgctgg agctaaaaag tattttaatc agttaaaaat
     6001 aggtataggt actcttagtg gaaaacaatt ttgcaaaaac caagctctta actcaatttt
     6061 aaatcttcgt catacaagtt tagaagaaaa tggtgttgat gtgcacttta atatagatat
     6121 agacaatcac ttgggtatag aacctataga tttatgtact attttttcaa attctttaga
     6181 taacgctata gaagcatctt tgaaaattcc tgatttgtca aatagaaaag tggtattaaa
     6241 ggcacgttgt gagaaggagt attttagcta tttattgaca aacaacaagg taaatcctat
     6301 caatagaaaa caagaactat ttatttcaga taaaaaagat agtaattctc acggatatgg
     6361 tattgagaat attagagaaa ttgttaataa gtacaatgga aaattggata tttcttatac
     6421 tgagagtgaa ttttctttat ttctttatat tagattattt tagtctaaaa ttagattatc
     6481 ttatataata caaattagat tgtttgatac tatgtaaaat tataataact tataattaaa
     6541 tatttacaca tatattcatt aacttaaaat ttaatcaaat gtgatatttt atttacctta
     6601 gtaaaaatgt gtgtgtctca aaataaactt tttagttgat gaggcactct tttttacatg
     6661 aaatcaaata tatttttatc ctttcaacaa tgaaaaatgg atttatctct ccattttgaa
     6721 acaagccctt tttctattaa ttactttctt aaaaaatata atacgatata taagataaat
     6781 atctaattgt acctatttct aattatatct attagaatac aacacctttg ccttttcagt
     6841 aaactcccta acaaaatcta gtttactatc tgtataagca tcacgattat gctcatactt
     6901 cttccaaagg tccaacttaa gtttttcata ctcctttgca acatctgggt ggtcaattaa
     6961 gtaatctcta aaaaacaact catcattatc acctacatac cttatatgca aatgaaaaac
     7021 tcgttcttca aacccctcta ctgtataccc tttattaagt gaaagcctac tactgctctc
     7081 agacatacaa atatatccat tcgactcaat caaatcttta atatctttca tattataatc
     7141 aggaattatc tcaatcagta tgtcaacaat gggcttggca taaatcgtac tcacagaagt
     7201 acttccaata tgacttattc taacaatttt ttgcattggc aatattccag ttagtctata
     7261 ttgttcttct ttaaaccaat ttttccaaca ttctttgtga gtagtcaaaa atataggaaa
     7321 caagttccat aactcctcta aagtcatatc ttccaacttc tttttcatta gttacctcct
     7381 tttaaatttg tactttatat tttttctttt tcaaatttac ttagttaata tttaacttta
     7441 ttttttatca aatcattttt ctaattatgt aaatttttct aaatttagtt tttaatgtat
     7501 tataacagat ttttaccctt cttacacttt tgtatctatt taaatattag aacatttttt
     7561 cttacttcta aatacagtaa gattgcttaa ataccaaata ggagcaaaaa aactctgtaa
     7621 tctaaaaaaa actacaacat ctttatgaga attaaaaaat gatagactat gttatcaaca
     7681 ttaagaaaca gatagaaaag aaacagagta tgtgctaaaa tgggaacata gaacagaatg
     7741 acaaattgga atttatggag gacattaaat atggagtata taatcaatcc ttgtagtggt
     7801 ataaaaatta aaataactag agggcagaaa attgaaattg tggatattga aggaggacag
     7861 gtcgttgatt tttttgcaga aatgaaagat gattcaactg aatttatatc tccaggtgtt
     7921 acaattgatt gtaatgagtc attaagatta caagttggga atttaatata ttctaataag
     7981 tatagaccta tgtttaaaat tttatatgat gatgtaaggg aacatgactt gctacatcca
     8041 tgttgtagac ctgagatgta cgatttcttt tatcacaatg gagaaaatca tccaaactgt
     8101 tttgataata ttaatcgcac acttggaact tcccatcaaa ttattcaccc cattaatttg
     8161 tttatgtaca caaaagtcaa tacagatggg agtattgaag tatgtgaacc tttatcaaaa
     8221 gccaatgaca aaattattct tgaagcattg gaaaacatga ctttagggat tgctgcatgc
     8281 agtgtttcag aaagttcttg taatagcaga aaatgtactt ctattaagat tttggttgat
     8341 tgacaaattt catttatcga aaaaatatca aaattaaaaa atgacgtcaa aggcgcaaaa
     8401 gggtaaccac ttgcgctctc aattcattat ggtttgttac gtatttatgg gtaaaaatcc
     8461 cttgattcta tgatgttttt cagacacaat tacaaatgag taaggatttt atactcatac
     8521 tctaaaaaat agcattttat tgcgtaacag aacgaaaaaa cagtgtgtac ctttttcttg
     8581 caatacacac tgtattcata gccactctag ctgttaactg ttaattatct cataataccc
     8641 ttactggtat tcatctaatc ttaacccctt ttaattattt tcatttataa ataaattcta
     8701 ttcttcccaa aatatcgtaa ttaaaatata ttaattaaaa tatcccaata agaatatctg
     8761 aaaaatcttc tacctatttt ttcaaacctt ttattcccat tcctcataca atagtgcaac
     8821 ttttagcaca gtataaatat accattagtc catataatct cattaacaaa tatatacaat
     8881 tattttcttc aaactctttt atatctaaga tatcacattt tcattttctt atattaattc
     8941 cttaactctc tttcaaatta ccaatttttt aatcaaatct tcattaaata ttctatcatt
     9001 attaaacatt catcattatc cctaaaaaat atgtgccgta tgttctttac acaaattttc
     9061 catcttatca tacacagcac cactatctct ctcatctgtc atagtcacaa ttacatcact
     9121 tggtctaaga attgtcttac ctctaggaat aatttcttct ccacctcttt gaattgctac
     9181 caaaagacaa ttttcaggcc actgtacatc ctgaattgcc ttgttcgcaa caggagagcc
     9241 aaacataaca gagaactggt ctagtatctt ttcgcccctc tctttatgta caggttctcc
     9301 attcttttca agtaacctct caagaagact ttcataaata ggtttagact tcataagtgt
     9361 agccacaata tatgccacaa ttgaaattac tgatagtgaa agcatttgac taacagaacc
     9421 tgtcatttca aaaattaata tgataccagt caaaggggca cgcacaatag ctgtaaaata
     9481 tcctgccata gccaaaagca caaagttatt tacataatcg ggattcattc caaaaacttt
     9541 aacacctacc ataccaaata ttccacctat aaatgctcct aaaacaagca atggaaaaaa
     9601 tattccccct ggtgcacctg acccaaaact aacagccgaa aatataaaac gtataacaaa
     9661 aatcaaaaca accattccaa aaatatattt atgacttgta agttcttcaa ctaaattgtg
     9721 tccactcccc agaacatcag gcataacaag cccaagaata ccagccatta taaatggaat
     9781 caacagtttt ccaaacgtac caattttagg aatcttcttg tataaagact gcacatatag
     9841 agtaaaccag ttgtaaaatg cccccataac tccaagaata acacctaaaa tcactattaa
     9901 tccataataa tcttgtggca acacatttcc aatctgaacc tcccatgact aaagtcacag
     9961 ggttcctgct tcatagaatt ttgcatacta aaatatgtct tactaattct ccacaggcta
    10021 tccccgtagt tcctacggtt cttacataag ttatttattt tgaattgtta ttagtcttaa
    10081 tccttctttt aatatattta tacttgcatt tatatctcta tcgtgagttt cattacaact
    10141 aggacaaatc cattctctta taataatgtt aacaaatgta attatttaaa acaattattt
    10201 agaaggtttt atatttaatt ttaaataaca tatttaagaa ccgtaagtct taacttttat
    10261 catttttgag gttgtcgttc acataagttc gctactacct atgcagttct cttatgaact
    10321 tcttacactt tcatgcaagc acagactata tcttatcctt cggcattatc cgttaaggtc
    10381 tacccacttc cactaccaat agcttgtagt gtacttccct caagaggaat agtcgttgaa
    10441 gtttctccta ttcggagttt acctgctgat tgcccatttt aaagtactta gggtttaacc
    10501 ttataccatc taaccaattt tttctacttt cgtaactttc acacttaggt ttatttcatc
    10561 cttatgtttt agtttggtta gctttagggg tttccagcaa ttcaagtagt attggatagg
    10621 ttctatccta tctctacata taggtttccc tatatgctga ctattttagc tactaactca
    10681 tgactaaagt cacaagtgtt cgtagctatt ttttaatcaa actggaatac agactccatt
    10741 cctaggaaat tggctgaaat atagtctgct gtcaaagatg ctgtcatcac agaaattaaa
    10801 acagatactg aaaagttttt atggacttct tcaagtgaaa acataacacc cgctagtggt
    10861 gcatgaaagg ctgctgataa tccagcactt gccccacagg ttaacaggaa tttttcctct
    10921 gtcttccctc ggtcaagagc tctagaaata cctttacctg ccatagcacc aagctgaatg
    10981 gaaggacctt cccttcccaa agcaagacca cccatgagtg ataagaatcc tccaataaat
    11041 tttgttggca acactcgcca ccatacttgt tttattttcc ctgtcatttc cccctcaagc
    11101 tgagggatac cacttccaga aatcattggc tcccagtcca ccaactttga tacaatccac
    11161 gcaagtactg caagtactgc aaaccaagct attattttta ttgtagaacc ttctacaaat
    11221 tttaaaattt ggctaagcca agtaccagcc tgccctaaaa gtatcctgta taaaagcaca
    11281 atcaaaccag ccacagcccc aaccataagt ccttcaccaa tcaaaattac ctgaaagtgc
    11341 tctgcccgtt tgataatatg agatgtatcc tttttcatac tattcctcct tcatccaata
    11401 attctacaca atctgaatct ccaatgacta aagtcatgag tgtgtacaga tattttttaa
    11461 tcaacaaaaa tagattttta cttactaaat ataagaaaat aattgctcaa tttctcaata
    11521 aatgtgaatt tattctttta ggtatttatt ctccacagtc gtgcttcttc cagcaaaata
    11581 tttattaatt cttgctttct ctgtgtatag attttacgat tgtcctcaaa ctgtaatgct
    11641 aatttttgtt tatgactatc atagagtttt gctttgtctg taaaagtatt tagataatct
    11701 cgaaaattga tataattatt ccatgcaaca ctattccatt caacaacatg aatatggtga
    11761 gtacgagtat ttttctcaaa atctcccata gcaaaaagta attgttttgg tacatcctga
    11821 cctcgaaaaa cgattccaca ttgctctaac ctttcgaggt ataatttagc ttcctctaaa
    11881 gaagcaacac ctacaacaat atcaataata ggctttgcgc taatactggg aatagaagtg
    11941 cttccaatgt gttgaatatc aatagcagtc ttatcccata tactttttaa taatataatg
    12001 acatcttttg cacttttatc ccatatcatc tgatgttcca ataatttaac cataccacat
    12061 tttaaaccta tcactatata ccacctcaat ataatccacc tttatatata ttacaatttt
    12121 ttctatcttg ataaatagtg atttagctat ttcacttttt cttgacactc gctacattcc
    12181 ctatcatgaa tagatataat tcctccacat ttagaacaag tatatctctc cttctgcttt
    12241 tgcataaact tctctaaacc gtactgctga acaaatttac tattttccat aaggcttgct
    12301 tgatatctct tgttataact tttttcaaga ttttttatga gtttacaagg aaaattgaaa
    12361 cattcaaaac aataaaacaa ccctttttga cagacacaat cctttatttt gcacttacgg
    12421 cagtgttctg gctttcctgt atcgccgttc aaacaaccag cacatggctt tttgtgataa
    12481 caatgcttat agcaaaccat acaattcatt ccacaaggag caaacataat cgtatcaata
    12541 ctctcttttg gcattttcat aacattttac tcctttcaaa aatccaattt gtcgaattgt
    12601 tatatattca tattgtaaca taaaaaatag ctaaaaaatt catgcacttt cattgccaat
    12661 aaattttcaa ggaaatatga aagtttaaaa ctaagaataa aaagagataa aaaggaagct
    12721 actaatcaaa atattcaaac acaagtaatc aatataaata acttaaggta tatttaaaag
    12781 tatatgatat taccagcagt tttaaataca aatataacca cacatgcctc aaaaacactt
    12841 attacagtat cttagaaact tagacaatac ataagattca ttaataaaaa agttctcaat
    12901 atagatatat ttaaccatgt tttgaatagt agataatcat atgattaaaa attaaatatg
    12961 acatagcgtt tgtggaatat aacacctaaa ttatgttata ataataaagc aggagtgtga
    13021 tagtgatgga tgaaaaaata ttagagttat tacaggaaat gcaaggtaat attagtaata
    13081 tgcaaggtag tatcagtggt atcgaaggca ctattagtga tatgcaaagc aatattaatg
    13141 gtatcgaaga cactattagt ggcatgcaag gcactattag cgatatgcaa ggcagtatca
    13201 gtagtatgaa tggcactatt agcgatatgc aaggcagtat cagtagtatg gatggcacta
    13261 ttaatagtat gcaagacagt attactgata tgcaagttga aattaaagaa gtcaatagta
    13321 ggttagacaa tatggaacct gatattaaag acttaaaaac tggacaagtt gaaactagta
    13381 gtagacttga tactattcag agtgatgtta cagaaattaa gtcagatgta aaaattaaca
    13441 gaaatacatt agatacagtg attaaacata cctcttcatt agtaaaagat acatcagata
    13501 ttaaaaatga tttaaataat atagagatag tcacatctaa gaattcgaat gatattgcta
    13561 aattaaaatc agttaaataa tatactatag taaaaaatac ctgaaaattt cacatacttc
    13621 tttaaagtta taccaaattt tatacagaaa tactgattat ccgacaacac actttactta
    13681 taaataattt attaaaaaaa tactcatttt atcctaaaat taacacgact aaatgagtct
    13741 tgatataata ataaaaaata agggagattg aacactaaaa agttgtgtat ctcccttata
    13801 ttctataata tagttatata atttttcagc ctaaaataaa agtccatctt tgattaaaac
    13861 acatcccctt atcacttata aaaggataaa atcttgtttt catttttcca tttatatctt
    13921 cttgcttaag agtaataatt ttttcttttg atactttaag tgattggtta aatttaacca
    13981 aacgactaag ttttgttcaa catctatttt tcatattttc caatacttaa tctatttttt
    14041 ataaataatt cttttatttc taactcactt acatttttta cataaaacga agcatataaa
    14101 tttcaacctt atcttgtatg gttcttaata cttaatgagt agcttaagta tcaatcatta
    14161 taaatttttc ccttacattt aacactctta ccatttccaa aatatacaaa atatattttg
    14221 aacatttgta caatgatgaa atacaataca tgaaaataca atatcataac tgttgtctaa
    14281 aaatagaagt tcttcaacat aacctttcac aaaaaacata ttatctaagt attttttgtc
    14341 tgctccttgt tttcctgttt gtagcatata aattactgca tctaaacata taactactca
    14401 cacgaaaaaa gaaaataaac ttccaaaata caagctctaa aaactacctc taaagttgta
    14461 taatgtttac taggaataag gttgtataac atatagttta aataatcatt ttttaaaatt
    14521 gcaagttatt gctttcaaaa ttagatgttt ttatatcaaa taaatgatta agaatttcta
    14581 aatttaatgg ctttataatg cactcccttt ctttgggata aaataatgtt gcacagatac
    14641 tttttctaaa gataacaatt ttatttttct atcaattcca ccagcatacc cagtcaaact
    14701 cccatttgtt cctacaacac gatgacatgg aataataata gagattccat tatgccctac
    14761 tgcaccaccg attgcttgtg ctgacatttt agatattcct ttttgttgag caactttata
    14821 tgcaatttct ccataagtga ttgttttacc atatggtatt tgttgtaaaa ttttccacac
    14881 tgtagtctga aaaggagtac ctaccatatg gagtgatggt gtaaaattgg gttcttttcc
    14941 cgaaaaataa atatctaacc atttctttgt ctgctcgaaa attggcaatt ctttttcttg
    15001 atgttcttgg tcaagattat aagcataata cttttgattc tcaaaccaaa gaccagttaa
    15061 cccaatatta tctgatgcta aaagaatatt tccaattgga ctatggtaat agctaatata
    15121 ttgcatacaa ttcctcctta tattctgaaa acttcactca aatcattaga cacttctttt
    15181 ctatctacca ttatgtaaaa acatactaat ataatttcct tctaactaca ctttcgttat
    15241 aatatctatc ctcatatcat attagtttta tatttacctg catctgttca tccttttttc
    15301 cctttccctt tgatgaatat aaaattcata catttaagct tcctactgta ttaactttta
    15361 tagaagtgta tattataatt ttatcactaa ataggccaaa aaaatatcga tatagcatca
    15421 agtaatatca taatactttc aaatgggaaa agtaagaata ggctgtaaaa aagaaaagta
    15481 tttttatgtt agaaatccag taaaatcatt agtagataga ataacagaaa acgaacaatt
    15541 tgctatttat cattttacac ataaatataa ttgacgcaat aaagtgtttt ctattctaca
    15601 acgattaata aggttagaaa aaagtaaaaa tgaactgtat atgtatgaag cattagtttc
    15661 tgtttctttc ctttggctta ttatgataaa aaatattgtt ttgctaccaa taaaacacaa
    15721 aaatataatt aatatccata tgcaaaaaat tttacgttat attgaaaaat actattgttt
    15781 tacattatat tgaagggtac tattgtgaaa acttaatttt ggagtactat caagcagtgg
    15841 taatatcaat aaatcagagt gctccagatg atttgaacta agtttaaata ctatacctta
    15901 taaatatttt actgagtttt gtttattaaa agcaactcaa tttctaaaag gcacaaatga
    15961 gctaataagt gacattgcta taaaagttgt ttttcatcaa ataatctatt ttagtaaatg
    16021 ttttaaagaa aaaacgggat attctccaaa agtgtacaga aatataaaaa aagagatatg
    16081 attttttatt tcttttgatt atccaaagag taaataaaaa atattgtaaa aaacttacta
    16141 acaacggcaa tgctttgaac tatggtaata ctttgaactt ttgattggac tttttttgct
    16201 aaaataatat atttaaatag caaagtaatc tgtttaatca ataaaaaata agagataaaa
    16261 gaaatcaact aaaactttta cctcttattt tgatagttta tcagagctaa tatttacact
    16321 ctttttattt ttgatacttc attaaaaatg atgcttactc tccattcact tttaattctt
    16381 cattaaaaat gatgcttatt ctccattcac ttttaattct tcattaaaaa tgatgcttac
    16441 tctccattcg cttttaattc ttcattaaaa atgatgctta ttctccattc acttttaatt
    16501 cttcattaaa aatgatgctt actctccatt cgcttttaat tcttcattag aactatgctt
    16561 actctccatt cacttttaat tcttcattaa aaatgatgct tactctctgt tcacttttaa
    16621 ttcttcatta aaaatgatgc ttattctcca ttcactttta attcttcatt aaaaatgatg
    16681 cttattctcc attcactttt gattcttcat taaaaatgat gcttattctc cattcacttt
    16741 taattcttca ttaaaaatga tgcttattct ccattcactt ttgattcttc attaaaaatg
    16801 atgcttattc tctgttcact tttaattctt tattaaaact gatgcttatt ctccattcac
    16861 tttcaattct tcattaaaac tgatgcttgc actctgtaaa ctcataaaca tccattaatg
    16921 cttcaccaaa tctttgatag tgaactactt ccctctcacc caaaaatctc aatatatctt
    16981 tcaaatcagg gtcatcagtt aaatttatta attgatagta cgtagccaat gctttttgtt
    17041 cagcagccat atcctcatgt aaatcagtta ccgaatcgcc aaagacatta atataacttg
    17101 tagtaaagtt tactccatta gaatctactg gctgaagacc atgtccaaaa ttagcataat
    17161 tactaccaag tccagcagcc ttaagctctt ctggagtaca attgcctatt aattgatata
    17221 acactgaaga aattatctca acatgagcca tttcctctgt acctatatca gttaaaagtg
    17281 cacgagattt tccagttggc atagtatatc tttgttgaag atatctagtt gcagctgcca
    17341 actcaccatt aggtcctccc aactgagtca tgatatattt tgccattcta gggtctgctt
    17401 gtcttatgtt aactggatgt tccagtgttt tttgataaat ccacatatta tcttactcct
    17461 ccttaatata tatttaataa taaatctaat tttaaagttt aataatttta tttataaaat
    17521 gatttgtccc atggccaagg ttcagatatc catgaccaag gatattcact tgattcatat
    17581 ccaaaattag ttaatgctcc atatttagat tcataatcac acacagcttg tgtaaattta
    17641 tcgcagtatc tgttgtatga atcaagagct ttcttatccc ttggattgtt atctaaatat
    17701 aaatttaatt ctatacaggc aaattgatat tctgaaattc tctctaaaag ttctcttcta
    17761 tttaatgaca ttagtacatg ttaccccctt ttttagctct aactctattt ttaggatttg
    17821 catatagcca atcattatag ttatttgact ctattaaatc taattcagga aataaagtac
    17881 ctctttttaa tgctgttttt ggattgtatg tgtcatcata aatttgacga ttgatgtatg
    17941 gtctagcaaa ttcacaacaa tagtcttgtt tatcctcttt taaatatccc attaattatc
    18001 ctccttaatt tttagaattt taaaatagca ttatttttaa aaattgtata ctggttctat
    18061 attataactg gtagttttaa taggtcttta ataagattaa atgattaaat aagtatcttt
    18121 ttttcttatt ttacctctaa aatttttcta attaatcttt cataaatatc tattttaaat
    18181 aaataatata gagtttatac aattttttat agcttaatta ctatt
//
LOCUS       DAEHWM010000088        18202 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.089, whole genome shotgun sequence.
ACCESSION   DAEHWM010000088 DAEHWM010000000
VERSION     DAEHWM010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18202)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18202)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18202
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.089"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(424..1140)
                     /locus_tag="KNP36_002922"
     CDS             complement(424..1140)
                     /locus_tag="KNP36_002922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874779.1"
                     /translation="MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIE
                     NDIKLIIMDVMMPNLDGLKTTLKIREKRNIPIILLSAKSEDMDKIIGLNMGADDYITK
                     PFNPLELTARVKSQLRRYINLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEI
                     KMTPLEYKILTLLMSRKGKIFSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPK
                     EPKYLKVVWGIGYKIEKLNY"
     gene            complement(1680..2480)
                     /locus_tag="KNP36_002923"
     CDS             complement(1680..2480)
                     /locus_tag="KNP36_002923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423139.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HBF0874780.1"
                     /translation="MTFKNKKFTINKYKILSIILVLCLILTAFSSYVNYSHKKFKDYV
                     VFYVQHQDDEVLWAGSAIVNAIKERGKNHVFVVLVSTGCGISVFDKYKKYENLTNIQK
                     SEYRNREFLASLNSLGVIRENIILLPETNTNGNTDFNYMEKIALTFEEKFKNVTHIAH
                     TYKLDDHLQHLKNGSVIQNLYNAGKIKDAKYFVKPKFADKITFNNKIVYKAHSTEDYE
                     KVKNACQQYKIVDELEYREGIGYKSDHKSFDKLLNNKDVPAILHTPNL"
     gene            complement(2794..3525)
                     /locus_tag="KNP36_002924"
     CDS             complement(2794..3525)
                     /locus_tag="KNP36_002924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874781.1"
                     /translation="MNIFDILRDYLLVQVDKYNLNMDMISIVSKSLSSKEAIGNTKRK
                     DFPIIVGKEIMLEADFKGAKGQAFTSTPSTFEGSLKDILSLDLHDNPHDRSLFIASLN
                     AVMKYLGKTDRTIHCKNNEPEICAKKFPEFIKMEFGNPKVAIIGYQPAIIDNIKDFFE
                     TRVLDLNPEFVDTIQYNVKIEDGIRDYEDVISWADLVICTGSTLCNNSIINFLSLNKP
                     VYYYGTTIAGASNILGLKRLCFCSK"
     gene            complement(3512..4207)
                     /locus_tag="KNP36_002925"
     CDS             complement(3512..4207)
                     /locus_tag="KNP36_002925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0874782.1"
                     /translation="MLKIKNLSLDLPNFKLQENSLNINNHEYFVLLGASGSGKTLFLE
                     TLAGRYPSAKGNVSYKENLISNLPPENRNIGFVYQNFELFPNMNVEDNIRFPLKLRKI
                     PIDEQILKANHLSKLMQIEDIKNRYPKNLSGGEKQRVAFARALIAEPDILLLDEPMSS
                     LDYITKKHISKILKDVYIKYKPTVIHVTHDISEAMFFAHKIGIMNNGKINHIFDLNEE
                     IKNKGESFFYEYI"
     gene            complement(4209..5000)
                     /locus_tag="KNP36_002926"
     CDS             complement(4209..5000)
                     /locus_tag="KNP36_002926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874783.1"
                     /translation="MKNKFFTTLLTGFFAIVFLFIVSPLLMLIIKGISYVPICLKSVE
                     VQYAIILSIKTSLISTIVCLLLAIPVAYFLHITKLPFKKLIIQIINLPMSLPHLVSGI
                     ALLLLFGRMGIGDSIYKIFKLDFIFTKQGIVLAQVFVNLPLTIKILYTSLNESNEKMI
                     FVARTLGCNSWEAFRFIILPNLKTGIISATVMTWSRALGEFGAVAMIAGSTRMKTEII
                     PTSIYLNMSTGDIDIAIGIAVILIFISLTCLMLFEIFFNREVDKN"
     gene            complement(5010..5822)
                     /gene="modA"
                     /locus_tag="KNP36_002927"
     CDS             complement(5010..5822)
                     /gene="modA"
                     /locus_tag="KNP36_002927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0874784.1"
                     /translation="MFKKLSVLALAMIISLSITACNSKENKANDESNTKVTTADDSKE
                     KETLFVYSGAGLKKPMDEIAKKFEKENNVKVEYSYAGSAQLIAQIETSHKGDVFIVGS
                     EPIYSKAFEKELVGEHKTVAHHTPAIVVPKGNPANIQKLEDLNKDGVKLILGDKESNA
                     IGKTTQKILEKNNLKSINDNVVSTAATVNEMIVQLTSSKADATIATKDSVFGNEDVEV
                     IEIAQDKNIDQLISAGIVNYSDKKDLANKFINYIESDEAKQIFKKYGFEPVK"
     gene            complement(6456..6656)
                     /locus_tag="KNP36_002928"
     CDS             complement(6456..6656)
                     /locus_tag="KNP36_002928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003723180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBF0874785.1"
                     /translation="MNNGIVKWFNNEKGFGFISMESGDDVFAHFSAIQTSGFKSLEEG
                     QKVSFDIVKGARGPQAENITIL"
     gene            complement(6881..7057)
                     /locus_tag="KNP36_002929"
     CDS             complement(6881..7057)
                     /locus_tag="KNP36_002929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874786.1"
                     /translation="MFRDKMDKCTHMLTAYISNSYDYCDFIDTQLDDFILEYGEKVVE
                     SCLHQVMVLVSKYN"
     regulatory      complement(7111..7200)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            complement(7380..7580)
                     /locus_tag="KNP36_002930"
     CDS             complement(7380..7580)
                     /locus_tag="KNP36_002930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874787.1"
                     /translation="MPKFTCNLKKYRQLKELTQEQLAEKVGVRRETIMRLEAGKYNPS
                     LKLAIDISKIVDTPIDELFIFD"
     gene            complement(7582..7932)
                     /locus_tag="KNP36_002931"
     CDS             complement(7582..7932)
                     /locus_tag="KNP36_002931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3796 domain-containing protein"
                     /protein_id="HBF0874788.1"
                     /translation="MIQKKFFMGFCGFLGFLSLRYFSSGNVADLTYIGFFAFFSNFII
                     AKINGDKADERYVQDEKAAMAFTGQLAIIELFILWCITIVSRNIELMCVLLSITYAIT
                     LNVYAIKLYILEEK"
     gene            8094..8282
                     /locus_tag="KNP36_002932"
     CDS             8094..8282
                     /locus_tag="KNP36_002932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0874789.1"
                     /translation="MTKYDFNFKLKVAKFYLNREGRDILIVKQYGVYDHSQVERWVNI
                     LGESELKIKKFSILYGSS"
     gene            complement(8759..8929)
                     /locus_tag="KNP36_002933"
     CDS             complement(8759..8929)
                     /locus_tag="KNP36_002933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874790.1"
                     /translation="MHVYQPKTSEYLLNTYAKSYLSSIVFLFDYITKNESRYAFFIID
                     FPFLSLDIFYKF"
     gene            complement(9318..9806)
                     /locus_tag="KNP36_002934"
     CDS             complement(9318..9806)
                     /locus_tag="KNP36_002934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBF0874791.1"
                     /translation="MKNKKGFTLVELLVVIAIIGILAIVALPALFKNIEKAKIAKLEA
                     DISAIKSASLSYYADESKYTEGNIIWWTKKDGKITVNSGIGDEDPLAHKIENLGMPYN
                     GSYTLVSSNGSEEYLELNIIIDGEISKSGLDKLEEDYGSSIKIPNDKNMIITFLSNKS
                     DN"
     gene            10610..10984
                     /locus_tag="KNP36_002935"
     CDS             10610..10984
                     /locus_tag="KNP36_002935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0874792.1"
                     /translation="MKEEILIEKLLRAELIVMEYLWKKDTLMPKKEIVKEIKQIYGWH
                     KSTIKILLKRLVAKRYLARYIINSQSHYKIIDSKEYYTFKKKVLKSSKSIKIMRSLTT
                     THKNVSKEKLDLLDEYYRNLKE"
     gene            11089..11463
                     /locus_tag="KNP36_002936"
                     /pseudo
     CDS             11089..11463
                     /locus_tag="KNP36_002936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430377.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
     gene            11753..12271
                     /locus_tag="KNP36_002937"
                     /pseudo
     CDS             11753..12271
                     /locus_tag="KNP36_002937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888399.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            12703..12957
                     /locus_tag="KNP36_002938"
     CDS             12703..12957
                     /locus_tag="KNP36_002938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874793.1"
                     /translation="MENKDIKLTICIFAFVIGIIVLFCCIGLGQFNMDCIIKQNGGSI
                     ATEQYNIYLEQSISQYRNFGSILVLLGGIGILFDKSVRKY"
     gene            12993..13316
                     /locus_tag="KNP36_002939"
     CDS             12993..13316
                     /locus_tag="KNP36_002939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874794.1"
                     /translation="MARDVFSVKMTPLEAQKMVEKNLEADLVSVDIYNLENNKSIIVT
                     IFEKYYARSNSDAGLVVICENTTGKTLVKITSTGSAIGLFQIDWGTGNNLIKRVKKIL
                     IDYII"
     gene            13590..13742
                     /locus_tag="KNP36_002940"
     CDS             13590..13742
                     /locus_tag="KNP36_002940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874795.1"
                     /translation="MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINF
                     KYHRKK"
     gene            13936..14859
                     /locus_tag="KNP36_002941"
     CDS             13936..14859
                     /locus_tag="KNP36_002941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SHOCT domain-containing protein"
                     /protein_id="HBF0874796.1"
                     /translation="MVGAFVLPNYAIILSEMSNLWGNFIMWILVPIITIVLLIIAVSS
                     MQYILVMIAFLLIIYSFIEKKIVMGLVSVLFFTYSIYLCATWEDKSLIADNKVETVRA
                     QRETVEREKEMERRRIQEEVDKERYIEKHGMEISENDLKVKLEALVPQEYKGKKYELK
                     VGKFKRYSMYFDLTVQNEKFSNSEECKKFVKEIANDLKKIKISKAYFKFHSKDDGGIY
                     NSVYIDYFRNIQNNVDNVENLEFNEFELKTEEEEKREQEKIEQEKNSYNNYIQNRVVD
                     PLDRIKKLKELLDSGAITQEEYNKKKKELLE"
     repeat_region   15126..15876
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=15126..15154
                     /rpt_unit_seq="gttttagattaactatatggaatgtaaat"
     gene            16067..16219
                     /locus_tag="KNP36_002942"
     CDS             16067..16219
                     /locus_tag="KNP36_002942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874797.1"
                     /translation="MKNCRKDKRGFSVLLDKEKLDKFDEVLEEKNLTKKEWLEEKIDE
                     ELEQKE"
     gene            16339..17152
                     /locus_tag="KNP36_002943"
                     /pseudo
     CDS             16339..17152
                     /locus_tag="KNP36_002943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894376.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="toxin Bro"
     gene            17204..17365
                     /locus_tag="KNP36_002944"
     CDS             17204..17365
                     /locus_tag="KNP36_002944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874798.1"
                     /translation="MCENLLDNMYIEKRKEEYRIKLLKIRETDIDIYNKLESIVYKLS
                     EKKLEKNNK"
     gene            complement(17693..18157)
                     /locus_tag="KNP36_002945"
     CDS             complement(17693..18157)
                     /locus_tag="KNP36_002945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874799.1"
                     /translation="MDFGEVKSELSDKDLKDNEEALNKYKKYYLKVYKYYSEMDSIKS
                     IQDIEIEQSRLKGQLQKNSNPIFALYISIMAVVFSTTINLTFDLSDITNYFIRMIMTL
                     LFIVLLIFLVNKGILPIAIPYRNNIQFYTTALDVLEDMKNKILRERKYKKRR"
BASE COUNT         7076 a         2140 c         2480 g         6506 t
ORIGIN      
        1 attataaaat tgtagattat taaattagtg ttgtaaaaca ttttattact tgtaaatgca
       61 tgaaacctta aggttaatag tatcaaagtt aatataagtg taagttctat ttttacctta
      121 gaaaaaaggc ttatgacatt ctctaagaat ttgactttag tctgtttatt ttttttatac
      181 aatgtaaaac atagtatagt caataaaaaa cttgataata taatacctat gcagacaaac
      241 tctaattcta cttttgacaa atgtacagga gtaccgaaaa aataaaaata agggagagca
      301 aactctttat aataataatt aatattataa gaaaagttat tattcaaatc ataaactgct
      361 tcaaataata tagaaactaa tagaaacagt aataataata aaataaattt tgctttagaa
      421 tcattaataa ttaagttttt caattttgta accaatgccc cacaccacct ttaaatattt
      481 tggttctttt ggattaattt caatcttttc tctaattctt ctaatatgaa cagcaatagt
      541 tctctcacaa ctataagcat cctcattcca gacattttca taaatctcat gagaagagaa
      601 aattttacct tttcgtgaca taagaagtgt aagtatttta tattcaagtg gtgtcatttt
      661 aatttcttca ccatctaaag aaactatttt tgtatctgta tttagctcta ggccaccact
      721 ttttagaata taattagtat catttgagtt atttgtatta ctaaaatcac ctaaatttat
      781 ataccttcta agttgagatt ttactcgagc agtaagttct agtggattaa atggtttagt
      841 tatatagtca tcagcaccca tattaagacc tataattttg tccatatctt ctgattttgc
      901 agataagaga attattggta tattcctttt ttctcttatt ttaagtgtag ttttaagccc
      961 atctaaattg ggcatcatta catccattat tattaactta atatcatttt cgattagtat
     1021 gtccaatgct tcaagtccat catatgcctt taaaacatta aagttatcag gtctcaaata
     1081 gaactctata gcatcaacta tctctctatc atcatctaca accaatatat tttgattcaa
     1141 cttattaacc cccttgaaat tttattttta accaattttt attttatacc aaaaagaggt
     1201 attagaaaac agtaagcccg ttcattatga aataaaaact agtactttta atatattgtc
     1261 aatgcatata gtaaatttaa aagtatagac gcccatatta atctgaaggt aaaagtttat
     1321 gaaaatatct agggtaatct atcacactcc ttatgttatt ttggtttatt aattttttag
     1381 gtttaaacat atattaacaa atataaataa caaatgagtt tcataattat taagaattta
     1441 taacaaatat ttattttaat gtagtttaat ataaataggt agcttaatgt agatatgtat
     1501 aaagcattta ataaggctta taggttttaa tgatgatatc tttatatatt ttaagagatg
     1561 atgaaattag atatgggtaa tagttgtatg agaaaaagta gtatagcaca aaaagtgcta
     1621 tatcacaaaa tctcaaataa tttccttttt ataacttaaa ttaaaagaat aaatatttct
     1681 tataaattag gtgtatgaag tatagcagga acatctttat tatttaataa cttatcaaat
     1741 gatttatggt cagacttata gccaatacct tctctatatt ctaattcatc aacaattttg
     1801 tattgttgac aggcattttt aaccttttca tagtcttcag tagaatgagc tttataaact
     1861 atcttattat taaaagttat tttatcagca aatttaggtt ttacaaaata tttagcatct
     1921 tttattttac cagcattata taaattttgg ataacagaac cattttttaa atgttgtaaa
     1981 tggtcatcta acttataagt atgtgctata tgagttacat ttttaaattt ttcttcaaat
     2041 gtaagagcaa ttttttccat gtaattgaag tcagtattac catttgtatt tgtttctggt
     2101 aataatatta tattttccct tattacacca aggctattaa gagaagctaa aaattctcta
     2161 tttctatatt ctgatttttg tatatttgtt aggttttcat attttttata tttatcaaag
     2221 acggatatac cacatccagt agatactaaa accacaaata catgattttt tcctctttct
     2281 tttatagcat taacaatagc actcccagcc cacaacactt catcatcttg atgctgaaca
     2341 tagaagacaa cataatcttt aaatttttta tgactataat tcacatagct actaaaagcg
     2401 gttaaaatca aacataaaac tagaataata gatagaattt tatatttatt tatagtaaat
     2461 tttttattct taaatgtcat ttaatcatct cctgaaaagt tgtcttagtt atattatcaa
     2521 acaaagtact aaaaattatt tcttaaatgc tgaaaaatat agagtagatt aatggaataa
     2581 aattttttta ttagtttaaa ataaagaaaa catttatgta taagactaat caaaatatta
     2641 atgattgata ggaattgaga tttaaaggga ttgtacattt attcgggatt cattttaata
     2701 gaattttact ttagtactta gaataaaagt aataactttt taaatttaaa gagtacacat
     2761 atatatttgt gtactccttg atgatatgat tgcttattta ctacaaaaac agagtctttt
     2821 taaacctaaa atatttgatg caccagctat cgtagttcca taatagtaaa ctggtttgtt
     2881 aagtgataga aaatttataa ttgagttatt acataatgta cttcctgtgc aaatcactaa
     2941 atcagcccaa gatattacat cttcataatc tcgtatacca tcttcaatct taacattata
     3001 ttggatagta tccacaaatt caggatttaa atctaatact cttgtttcga aaaagtcctt
     3061 aatattatca attatggctg gttgatatcc tataattgct acttttggat taccaaattc
     3121 catttttata aactcaggga atttttttgc acatatctct ggctcgttat ttttacaatg
     3181 aatggttcta tccgtcttgc ctaagtattt cataactgca tttaatgatg ctataaaaag
     3241 acttctatca tgaggattgt catgtaaatc taatgataat atgtctttta aagaaccttc
     3301 aaatgtagat ggagtagaag taaatgcttg tcctttagct cctttaaagt cagcttcaag
     3361 cattatttct ttaccaacta taattgggaa atctttacgc ttagtatttc caattgcttc
     3421 ttttgaagat agagatttgg acacaatact tatcatatcc atatttaaat tatatttatc
     3481 aacttgtact aatagataat ctctcaaaat atcaaatata ttcatagaaa aaagattctc
     3541 ctttattttt tatttcttca tttaaatcaa aaatatgatt tatttttcca ttgttcatta
     3601 ttcctatctt atgagcaaaa aacattgctt cagaaatatc atgagtaaca tgaatcactg
     3661 ttggtttgta ttttatgtag acatccttca aaattttgct tatatgtttt tttgtaatat
     3721 aatccaatga actcataggt tcatctaaaa gtaatatatc aggttcagct attaaggcac
     3781 gtgcaaaagc aactcgttgc ttttcacctc cacttaaatt tttaggatac ctatttttta
     3841 tatcttctat ctgcattaat ttagataagt ggttagcctt aagaatctgt tcatctatag
     3901 gtatttttct caatttaagt ggaaacctta tattatcttc aacattcata tttggaaata
     3961 attcaaaatt ttgatataca aatcctatat ttctattttc tggaggtaag tttgatatta
     4021 aattttcttt gtatgataca tttcctttag cagatggata tcttcctgct aatgtttcta
     4081 gaaatagagt tttacctgac ccactagctc ctaataaaac aaagtattca tgattattaa
     4141 tatttaaact attttcttgt aatttaaaat taggtaaatc aagagataaa ttttttattt
     4201 ttaacatatt aattcttatc aacctctcta ttaaaaaata tctcaaaaag catcaagcat
     4261 gtaagtgaga taaatatcaa aattacagct attccgattg caatgtctat atcaccagta
     4321 gacatattta aatatataga tgtaggaata atttcagttt tcatacgtgt agaacctgct
     4381 atcatagcta ctgcaccaaa ttcaccaagt gctcttgacc aagtcattac agttgcagat
     4441 atgattccag tttttagatt tggaagaatt ataaatctaa atgcttccca actattacat
     4501 ccaagggtac gtgcaacaaa tatcatcttt tcattacttt catttagtga agtgtaaagt
     4561 attttaatag taagtggaag atttacaaat acttgtgcta aaactatacc ttgctttgta
     4621 aatataaaat caagcttaaa aatcttataa atggaatctc caatccccat tcttccaaac
     4681 aaaagtaaaa gagcaattcc tgatactaag tgtggaagag acatagggag atttattatc
     4741 tgtataatca gttttttaaa tggtaattta gtaatatgta aaaaatatgc tactggaata
     4801 gctaataaaa ggcatactat agtagatatt aaagatgttt taatactaag tattattgca
     4861 tactgtactt ccactgattt taagcatata ggaacataac ttatcccttt aatgattaac
     4921 ataagaagtg gtgatacaat aaacaaaaag actatagcaa aaaatccagt aagtagagta
     4981 gtaaaaaatt tatttttcaa gtttaatcac tacttaacag gttcaaaacc atatttttta
     5041 aatatctgtt tagcttcgtc tgactctata taatttataa atttattagc taaatctttt
     5101 ttatcactat agtttacgat tcctgctgat ataagttggt ctatattttt atcttgggca
     5161 atttctataa cttctacatc ttcattgcca aagaccgaat cttttgtggc tattgtagca
     5221 tcagctttac ttgatgttaa ctgtacaatc atttcattta cagttgcagc tgtagagaca
     5281 acattatcat ttatagattt taaattattt ttttcaagta ttttttgtgt agtcttacct
     5341 atagcattag actctttgtc tcccaaaata agtttaactc catctttatt taagtcttcc
     5401 aatttttgaa tattagctgg atttccttta ggtacaacta ttgcaggtgt atgatgtgca
     5461 accgttttat gttcacctac aagttctttt tcaaaggctt ttgaataaat tggttcagaa
     5521 ccaacaataa atacgtcccc tttgtgactt gtctcaattt gagctattag ctgtgcagaa
     5581 cctgcatagc tatattcaac tttgacatta ttttctttct caaatttttt tgctatttca
     5641 tccattggtt tctttaaacc tgcccctgaa tagacaaaaa gagtctcttt ttcttttgaa
     5701 tcatcagctg ttgtcacttt agtattagat tcatcattag ctttgttttc tttagaatta
     5761 catgcagtaa tacttaatga aataatcata gctaaagcta gtactgaaag ttttttaaac
     5821 ataagatatt cccccttagt aaattaatgt aaattctttt ttagtatatc atactaagaa
     5881 aacgatgtct aagtttttgt tatgttttat aatgttttgt tatgttttgt tatgtatagt
     5941 taagaaaaaa tctatttata atgttatttc tataggtagt tattttattt ttaattttta
     6001 ttaatacttt aaagtatttt aaatttaaaa acttaaatca aattaactta ttgtagattt
     6061 tttacttttt aactaatttt atatttatta tatttcagtg aaaaaataga acattgaaac
     6121 atatagatat gttttaattg ctttttatta acaaattact aaaaatgtta tatcagaatt
     6181 gaatacaaaa gaaagagtat gtatttatga gatagttgaa aattttgatg tgccacaact
     6241 aaaattatta tattactata tatttaatta aaagagtact tgtaggttta agtacatact
     6301 ttataaatat atttttgtta gatttatttt ataaaaagta tttagactaa gtattatttt
     6361 taagtatttt cttgttgaag ttattttttc cttttttaca aaattcgtaa ataaaaaaaa
     6421 gactcttaaa agagtctttc cgaaaaatct atatattata atatagttat attttctgct
     6481 tgaggacctc tagcgccttt aactatatca aagcttactt tttgaccttc ttctaatgat
     6541 ttaaatcctg aagtttgtat agctgagaaa tgagcaaata cgtcatctcc actttccatt
     6601 gatataaatc caaatccttt ttcattatta aaccatttta ctattccatt attcattaaa
     6661 aatactccta ttaacctata tcaagatata cttgatttac ttgtgtatta ccacaaatat
     6721 tattgtatca tagattaaca taaatgtcta tttaattata atttttagtt aacattttta
     6781 tttattctta atatgaaaat aaatttaaac attttatatt accaatatat taatgtaaat
     6841 gtagataaaa ctaaaaaggg ttttctagaa aaaaatctgt ctaattatac ttacttacca
     6901 ataccatcac ttgatgcaag caagattcca caactttttc tccgtactct aatataaaat
     6961 catctaactg tgtatctata aaatcacaat aatcgtatga attactaata taagcagtta
     7021 acatatgtgt acatttatcc attttatctc taaacataat gtatttatcc ccctaaaaaa
     7081 ctttcatgaa aaacaaaaag aaaatatctt tttggcaact ggctgacata acttatttta
     7141 taagcgttag tccctatagc tttgcgtcac taaatttctc tagttttgcc gatttagttt
     7201 tattctacag attaataata caatagaatt agttatcatt caacatatct agttgaataa
     7261 ttaataaatt tatatatgaa ctttaaatta tttgaaaaaa taaaaagccc ctctgtcagg
     7321 agtgacttaa aaattgaatt taagtttgta tttaaaacac atttttaata atgcaaaaac
     7381 taatcaaaaa taaacaattc atcaataggt gtatctacta tttttgatat atctattgct
     7441 aatttcaaag aaggattata ctttcctgct tctaaacgca taatggtttc tcttctaact
     7501 cctacttttt ctgctaattg ttcttgagtt aattctttta attgtctata tttttttagg
     7561 ttacaagtga atttaggcat attatttttc ctctaaaata taaagtttta tagcataaac
     7621 atttaaagtg attgcatatg taattgatag taaaacacac attaattcta tattcctaga
     7681 cactatagta atacaccata aaatgaataa ttctataata gcaagctgtc ctgtaaatgc
     7741 catagctgct ttttcatctt gtacatacct ttcatctgct ttatcaccat ttatttttgc
     7801 tataataaag tttgagaaaa aagcaaaaaa tccaatatat gtaaggtcag caacattgcc
     7861 agatgaaaaa tatctaagac ttaaaaatcc aaggaaacca caaaaaccca taaaaaattt
     7921 tttctgaatc attttttatc ctccttagta attttaaaag agatatattt atatctttat
     7981 gatacaaata tatctctttt atattctttt atcaatagaa aatcagtatt atacaatatt
     8041 tatactgcac cataattgtt agagcaaaaa tctaatgctt gagatgttta tgtatgacta
     8101 aatatgattt taatttcaaa ttaaaagtag ctaaatttta tttgaataga gaaggaagag
     8161 atattttaat agtaaaacaa tatggagttt atgaccattc tcaagttgaa agatgggtta
     8221 atatattagg agagagtgaa ctaaaaataa aaaaattttc tatactatat ggttcaagtt
     8281 agatgttata aactatatga tgataactaa atatagtgta caataaatcg ctaagtattt
     8341 tggaataaac aatagcacag ttatagcaac atgaaaataa aaatttttac atagtggtgt
     8401 tgatgccttt tctaaaatga aaggaagacc ataatgaata aaaacaaaaa cactaaagaa
     8461 aaaataaatt aacaagagaa caagaattag aatatgaaaa taaattttta aaagatgagc
     8521 ttgagttttt aaaaaagatg tgtgtctcag ggaagccaca ttaaaaaaca gtggtatcat
     8581 tattaatcaa aagaaagtta gatgtattat caaaaaatta gaacttaaat gcatagcatt
     8641 ttttcataaa tcacataaat ataactccta taaaggtata attggaaaag taaaaaataa
     8701 taaaacaaat agaagattta aaacatcaat agcatatcag aaaataacaa atgatatgct
     8761 agaatttata aaatatatct aatgataaaa atggaaaatc aattataaaa aaggcatatc
     8821 tcgattcatt ttttgttata tagtcaaata agaatactat agatgaaaga tacgattttg
     8881 catatgtatt aagtaagtat tctgatgttt ttggttgata cacatgcaat aaagaagttg
     8941 tgtttgcaga taaattagca aaactatagt ataagttgca acaataaaga aaatgaaaat
     9001 tatcatacta aagcataagg catgttacaa ttttattaga taggacatta acatacacta
     9061 aagtactttt tattataaag agtacttatt tttttgaaat tcattaatgt ataaactatc
     9121 aagaatatta ctcaacataa tttaaaaaca acttgaatag gtatttttaa attatgtgat
     9181 ataataaaaa atagaagtgt atgccaatac acttctgtag ttataactaa gcattctatt
     9241 cttgaggagt gcttttttca tttttataac caactctttt tactttaaca ataattatca
     9301 gacctatata tttattttta attgtctgat ttattagata aaaaagttat tatcatattt
     9361 ttatcatttg gtatttttat tgaactacca taatcttctt ctaatttatc tagaccactt
     9421 ttacttattt ctccatctat aattatgttt aattctaagt attcttcact accattagat
     9481 gacactaaag tgtacgaacc attataaggc atgcctaaat tttctatttt atgtgccaaa
     9541 gggtcttcat caccaatacc agagtttact gttatttttc catctttttt agtccaccat
     9601 attatgtttc cttcagtata ttttgattca tctgcatagt agctaagaga cgcacttttt
     9661 attgcactta tatcagcttc aagtttagct atctttgctt tttctatatt tttaaataat
     9721 gctggaagtg ctactattgc caatattcct attatagcaa ttactactaa taattccact
     9781 agagtaaatc cttttttatt tttcatttat ttcccctcca tataaaatta ataatatata
     9841 aatttttatt ttgttaattt ctactttcta tattttacca tatatagaca aaaaaatcac
     9901 tttctatgac aaatatacta ttattttaca atttatggaa atgatttaaa atgacatttc
     9961 ttgttagaaa agatataaga aatggattaa aataaagaaa actacagtca tatcaatgtc
    10021 aataatatta tttaaaagca gatgaaaata aaaagaggac tcagaaaata atgtctattt
    10081 aattatactt acttaccaat accataactt gatataaaca agattatact acattttttt
    10141 atgctctagt ataaaatcat ctaactgtgt atctataaaa tcaaaataat tatatgaact
    10201 atcagtataa taagtcaaaa tatgtataca tgaatacata ttttaaaaga tatatattat
    10261 tacataccta aaaaactttc ataaaaacaa aaataaaata tgcttttagt aacttgttaa
    10321 cataacttat aatttatttt ataagcatta gcctatatag ctttgtgcta ctaaatctct
    10381 ttgattctaa cgatttagtg ctattctaca actaaaataa tacaatagag ctatttattg
    10441 tttggtagca ttgtttgtaa attaaacaaa tttatacata tgaatattat tttacattca
    10501 aaaaaacaga ctaaatatgt agaatatttg gtaaaactta cctctagttt ttgtcttaaa
    10561 aagctcctat tattaactta agttagaaga attaaggaag tgacataaat tgaaagaaga
    10621 aatattaata gaaaaattat taagagcaga attaatagta atggagtatt tatggaaaaa
    10681 agacactcta atgcctaaaa aagaaattgt aaaagaaata aaacagattt atggatggca
    10741 taaaagtaca ataaaaatac tactaaaaag gctagttgct aaaaggtatt tggctagata
    10801 tattataaat tctcaatctc attataaaat aatagatagt aaagaatatt atacttttaa
    10861 gaaaaaggta ctaaaatcta gtaaaagcat aaaaataatg cgttcactta ccactacaca
    10921 taaaaatgta agtaaagaga agttagacct attagatgag tattatagaa acttaaaaga
    10981 atgatatagt aaaaatcgaa tgtaattatt taccttaatt cttttgtttg taaaacttta
    11041 ttgatacaga atttaacata tacataaatt ggtaaaggaa tgtatactat gaaaattagt
    11101 aaattaccag aagcggaatt aaaagttatg agatatattt gggaatcaga aaaggtatta
    11161 atatcaagag aaatcaccaa gtctatggaa caaaaatatg aatggaaaga tacaactata
    11221 tttacagtat taaaaagatt actaaagaag agagttttta gaagcggaga aaatagataa
    11281 gtgtacacac tataatgtat tagtaaaaaa aaataatatc agagatttta aacaaaagaa
    11341 tttttaaaga atacacataa aaattcaata ttaagtttaa tgtcagcact atgtagtaag
    11401 gatgatgaag tagatggtga tattttaaat ttattagaag aatattttaa gaatttgaaa
    11461 taagaaaatg acaaattgat acataataaa taaaatgaag gtatgaaatt ataacttttt
    11521 ctaccttcat tttgtttatt attctgaaca tgttaagaaa atgaaataag tttgtatttt
    11581 atttatataa attttaatag aatatgtata gtatatagta gatagaatgt ataaaaataa
    11641 aaactgttca ataagaatta atatacatta attcagctga atccaatcaa aatacttaaa
    11701 taaaagtaat ctgaaaataa cataattcaa atcaatttat tcaaataaac ctcaatttat
    11761 ctcaaatctt aagaagtcat taaacaaact tgctaaatta caaagagaat tatcaagaaa
    11821 aacaatcggt agtttaaata gaaataaagc aagattaaaa gttgcaagac ttcaagaaca
    11881 tatagctaat caaagaaatg attttctaca aaaactatct actaaattaa taaaagagaa
    11941 cgatattatt tgcatagaag atttacaagt aaagaatatg attaggaatc gtaaactatc
    12001 tcgctcaatt tctgatgtgt catggtcaga gtttattcgt caattagaat acaaggctaa
    12061 ttggcatggt agacaaattg taaaggtggg taaattcttt gcaagttcac aaatatgcaa
    12121 taaatgtggg tataaaaacg aggaagtgaa ggacttaaat ataagagaat ggatttatcc
    12181 tagttgtaat gaaactcacg atagagatat aaatgcaagt ataaatatat taaaagaagg
    12241 attaagacta ataacaattc aaaataaata acgtatgtaa gaaccgtagg aactacgggg
    12301 atagcctgtg gagaattagt aagacatatg ttagtatgca aaattctgtg aagcaggaaa
    12361 cctgtgactt tagtcatggg aggttcaggc tagtattact cattattgta ttcaaaagct
    12421 aaagtggaaa cctagtgaat atatgaattt agaagttaat gagagagcat tagcagccga
    12481 ctcaatactt attaaaattg aagatgaaga agaaacaatg aaagaagctg aaagagagaa
    12541 aaagagaggt agaagaaggt agaatttaaa gttaaaatag ttacattgct aatatatgaa
    12601 aatgttacaa atttggaaat agatggatat atatgttgta tagtataatg tagataatat
    12661 atcaccaagt aaaaaacaac aaataaatct aaattatgag gggtggaaaa taaagatatt
    12721 aaacttacaa tatgtatatt tgcttttgta attggaataa tagtgttatt ttgctgtata
    12781 ggtctaggtc aatttaatat ggattgtatt ataaaacaaa atggtgggtc aatagctacc
    12841 gaacaataca acatatattt agaacaatct atttcacaat atagaaattt tggttctata
    12901 ctggttttac taggaggaat aggaatactg tttgataaaa gtgtcagaaa atactaaaaa
    12961 agtatatttt tatttaggat gtgatgaatg atatggcaag agatgtattt agtgtaaaga
    13021 tgacaccact agaagcacag aaaatggtag aaaaaaattt ggaagcagat ttagtttctg
    13081 ttgatattta taacctagaa aataataagt ctataatagt tacaatcttt gaaaaatatt
    13141 atgcaagaag caatagtgat gcaggtttgg tagtgatttg tgaaaatact acaggaaaaa
    13201 cacttgttaa aattacctca actggtagtg caattggact atttcagatt gattggggaa
    13261 caggtaataa tttgattaaa agagtaaaaa aaatacttat tgattatatt atttaattat
    13321 tttatgtaga tattcttagg ttggtatgga atttgtacta acctattaag taatcaataa
    13381 aactaaataa acatagaaag cacttacaaa tatgtaggtg ctttttattg aaaaaataga
    13441 aaataaaata aaaagtaaga tataggaaaa atatgtaaga attatatgtt ataataattg
    13501 tagcaagaag atgtaatcta caatttatag agtggagttc atgtattaaa aaattatcct
    13561 cccaacgata agaagggagg tgaatataca tggataattt tttatttaat gtgttagcta
    13621 gtgtaacagc tagttacata gtttatttga ttagcaagtt aatcaaaaaa gtaaaaagcc
    13681 actctaccgc aaagagtgac ttaaagattg atataaattt taaatatcat cgtaaaaaat
    13741 aactttcagt tatagaactt cactctaccg caaatagatt gtagttcttc ttgtttttat
    13801 tataccacaa attagaaaaa atattgcata taatattttt tatagtcaat aaaaatatga
    13861 aattttttat acacaatgat gatgaatcta actagatgaa taaatttaat tgtaaataag
    13921 aaagtactta cttaaatggt aggtgctttt gttttgccaa attatgctat aatattgagt
    13981 gagatgagta atttgtgggg gaattttata atgtggatat tagtaccaat aataacaata
    14041 gtattactta taatagctgt ttcttctatg caatatattt tagttatgat agcttttttg
    14101 ttgattatat attcttttat agaaaagaaa atagttatgg gtcttgtgtc agttcttttt
    14161 ttcacttatt caatttatct ttgtgcaact tgggaagata aatccttgat agcagataat
    14221 aaagttgaga ctgttagggc acaaagagaa actgtagaaa gagaaaaaga aatggaaaga
    14281 agaagaatac aagaagaagt agacaaagaa agatatattg aaaaacatgg aatggaaata
    14341 tcagaaaatg atttaaaagt taagctagag gctttagtac ctcaagaata taaggggaag
    14401 aaatatgaat taaaagtagg aaaatttaaa agatatagta tgtattttga tttaactgta
    14461 caaaatgaaa aatttagtaa ttctgaagaa tgtaaaaaat ttgtaaaaga aattgctaat
    14521 gatcttaaaa aaattaaaat aagcaaggcg tactttaagt ttcattcaaa agatgacggc
    14581 ggtatatata attctgttta tattgattat tttagaaaca tacaaaataa tgtagataat
    14641 gttgaaaatt tagaattcaa tgagtttgaa cttaaaaccg aagaagaaga gaagcgagaa
    14701 caagagaaaa tagaacaaga aaaaaacagt tataataact acattcaaaa cagagtggtt
    14761 gacccactag atagaataaa gaaactaaaa gagttgctag attcaggagc aattacacag
    14821 gaagaatata ataaaaagaa aaaagaatta ttagaataga taatatagta agcacttaca
    14881 agtatgtagg tgcttttaaa tttacaaagt attccatttt aattttatag tttagatttt
    14941 atgatataat aaaaatatag aagttttgca gtgtgcgata tttgttacaa agtagggctt
    15001 aatacttgaa atctaagatg ttgagggtgc gtgataagtg ttatcaattg cactattgcc
    15061 cgctcactgc aattttaaga gtattgtata tatgtaggta ttggaaatgc taagtttatt
    15121 ttggggtttt agattaacta tatggaatgt aaatattaca tgggtaaaaa ttttgatgat
    15181 ttttatgaca gttttagatt aactatatgg aatgtaaata ttacatttaa tttgcattgc
    15241 tttgatgact tctttgtttt agattaacta tatggaatgt aaatgcgtac aaggttgaga
    15301 agctccgcaa tctcaacgtc gtgttttaga ttaactatat ggaatgtaaa tatttgaaag
    15361 gaataaattt taaatgaatg aaaggatagg ttttagatta actatatgga atgtaaatca
    15421 gccaaaaact tcgaatttga actaaaatgc gtgggtttta gattaactat atggaatgta
    15481 aattctcatg actattgaat aaatataata aacaagcata cgttttagat taactatatg
    15541 gaatgtaaat ttagaatcaa aagcacttaa tcctagttct ttcatagttt tagattaact
    15601 atatggaatg taaatagctt tttagcttcg tctactactt tataagcaaa gcgttttaga
    15661 ttaactatat ggaatgtaaa tgatgaacaa taaaacaatc atctaaagac gaagaaagtt
    15721 ttagattaac tatatggaat gtaaatgttc ctgttgtgtt ttttactaat cccattttat
    15781 atgttttaga ttaactatat ggaatgtaaa ttgctgtgat ttcactaata aaacaattaa
    15841 taattgtgtt ttagattaac tatgtggatt caaaattaaa taaacaaaga aagcacttac
    15901 aaatatgtag gtgcttttat tctgctcaaa attggtcggt tgggtaaaat cattagaaaa
    15961 aattagtaaa aacctctttt ctgtaactcg ttacaatatt attattaatg taacgagtta
    16021 cagaaaagag gtgaataaaa tagcaactaa aagtagggca gagtatatga aaaattgtcg
    16081 aaaagataaa agaggtttta gtgtactttt agacaaagaa aagttagata aatttgatga
    16141 agtattagag gaaaagaatc taaccaagaa agaatggcta gaagaaaaaa tcgacgagga
    16201 actggaacaa aaggaataaa aaataagggt cactcccacc gaccaaagtt tgagtaaccc
    16261 ctatgatgta tactatcgta tatcaattat aatatatgtc attccttaaa aaaatcaatt
    16321 attaaggagt gtaatattat gaaaaatgaa ttaatgatgt ttgaaggaaa agagattgaa
    16381 gtatttgaat ttgaaggaag aattttattc aactcaaaag atgtagcaaa ttgtttagac
    16441 ataaaaaatg ttaatgagaa tataatactt atgaatgaaa agcaagttgt aaagttaaga
    16501 aattcggata tcagtaatac tgacatccga aaacttaata atgctggaga aaattttctt
    16561 actgaaagtg gagtgtataa attaatcttt aaatcaagaa aagaagaagc tgagagattc
    16621 caagactgga taagcgatga agttttacca agcataagac aaactggtgc atacataact
    16681 aataatgtaa tcccgaaaag ttgagagaaa aagcaagtga gattgaaaaa ttacagttgc
    16741 ttataacagt acatctatgt taaaagaatt gctagatgat gcaggctttg acaataaatc
    16801 aaaactatta acagctaaaa cattatataa gaaagcagaa attgatttac caatagagat
    16861 aaacgaagaa gaacattatt ttgatacaaa acaaatagca tctaaactga aaatatattc
    16921 taagagtaat aaaccagctc agatggctgt ttgtgagatt attaaaaaga ttgatttaga
    16981 agatggtgaa gttaaaggtg tttgggaaat taatggttct tggactggta ctgtaaataa
    17041 atatacaaag agtgtaatag ataaggtgag aacttggata gaggaaaata atagacctac
    17101 caagattgca ggtgagaaga agaattatta tgtattttac aaaattgagt aaatttatca
    17161 gttgtattaa ataatttagt ttagttttgg ggggattaat acaatgtgtg agaatttact
    17221 tgataatatg tatattgaaa agagaaaaga agaatataga attaaacttt tgaaaataag
    17281 agaaacagat atagatatat ataataagtt agaaagtata gtatataaac tttctgagaa
    17341 aaaattagag aaaaataata aatagacata taaagcactt ggatattcta ctgtttcaag
    17401 tgcttgtttg gtataaaatg gtataatgga gatagagaat tatattaacc aaaaaatgga
    17461 gaaaatagag aagatgattt agttgacgct ttatcagtag gagtacctgc aggtaagaca
    17521 gaatctctag tacgattagt tggagatgga ataagtgata ctcaaaaaag tttaataaat
    17581 aaaagagaat ttagaaatat aactcaaatt ggtggaaatg gaaatgagaa agcatttagt
    17641 gaagtagaaa acttagttaa atagattaga aggtagcaac tagagttggt tgttaccttc
    17701 tttttttata ctttctctct ctaagtattt tatttttcat atcttctaat acatctaatg
    17761 cagtagtata aaattgtata ttatttctat aaggtatagc tattggaaga atgcccttgt
    17821 taactaaaaa aataagaagt acaataaata aaagtgtcat aatcattcta ataaaataat
    17881 tagtgatatc tgataaatca aatgttaagt taattgttgt agaaaataca acagccataa
    17941 tagatatata caaagcaaaa atggggttac tatttttttg taactgtcct ttaagcctag
    18001 attgctctat ttctatatct tgaatacttt ttatggaatc catttcacta taatacttat
    18061 aaacttttaa ataatatttt ttatacttgt ttaaagcttc ttcattatct ttaaggtctt
    18121 tgtcacttaa ctctgattta acttccccaa aatccataaa atccctccta caatgttata
    18181 taatatactt taatttatag ca
//
LOCUS       DAEHWM010000089        18199 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.090, whole genome shotgun sequence.
ACCESSION   DAEHWM010000089 DAEHWM010000000
VERSION     DAEHWM010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18199)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18199)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18199
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.090"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            227..1657
                     /locus_tag="KNP36_002946"
     CDS             227..1657
                     /locus_tag="KNP36_002946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBF0874800.1"
                     /translation="MDIKNKIKSIFLPEKNDYLDDEEFEYDIENNEEDLKEDNKVHLN
                     DLSRVKYDYRELKDIENQTEEMCLLAVKQDGTIIEFVKDKTYKVCMEAVKQTYKSLKY
                     ITNQNEDICIEAVKQNYRALYYINNKTENVLIEAIKNASTYDVMEVFKFVEEQTEDVC
                     LAFIERASKNDVAEILKGIKEQTPAICLEAVKKDGKSLAYVKEQSNSICLEAVKENYS
                     ALSCVKEQTEEICIEAVKQNDFALYYVNEQTEKICMEAVKRSYMALQYVNKQTEEICL
                     EAVRIDGRALQYVKEQTEEICLESVRQNGKVLQYVKKQTENICIEAVRGSFEELEIKE
                     ILSYVKIPTERIFVEAVKQNGKILKYVENQTELICLEAVRENYNALAYVKEQTEKICL
                     EAVNQSYEALKYVKEQTEEVCLKAVKQDYRMLKYVNNQTEKICLEAVKQNYRALEFVD
                     NQTEKVCLEAVKQNRKALQYVKQKQS"
     gene            2025..2603
                     /locus_tag="KNP36_002947"
     CDS             2025..2603
                     /locus_tag="KNP36_002947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory gene regulator B family protein"
                     /protein_id="HBF0874801.1"
                     /translation="MFKRYAEKMTSVLICNNMIDNNESKVYSYGFEILIAFIVNITTM
                     LFIGFLFGKFTYVLFFLMCYCPIRQFSGGYHADNYFRCLLTFIFIILSTILIIENINI
                     DLFKNIIMIIASVSWVGICVLCPIEHRSNPISDREKLVYKKTAIFISTVVLLITISSL
                     SLSIFVDYFTYSAFAMFWIFVMLVLGKLKAKV"
     gene            2633..2779
                     /locus_tag="KNP36_002948"
     CDS             2633..2779
                     /locus_tag="KNP36_002948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="HBF0874802.1"
                     /translation="MKKFIVRFMKFASSLALSTAILSANSTCPWIIHQPKVPKEISNL
                     KKTN"
     gene            3075..4454
                     /gene="scfB"
                     /locus_tag="KNP36_002949"
     CDS             3075..4454
                     /gene="scfB"
                     /locus_tag="KNP36_002949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="HBF0874803.1"
                     /translation="MSMIHKFSMNGYNIVLDVNGGAVHVLDDVAYDLLDFYKEKSKEE
                     ILEILKSKYQEEKINEAYEEILNLEKEGLLYTEDTYQYHPSFVHREPVVKALCLNVAH
                     DCNLKCKYCFAAQGDFGGEKELMSFEVGKAAIDYLIANSGSRKNLEIDFFGGEPLMNF
                     EVVKQLVDYGRSVEKDYNKNIRFTITTNGVLLNDEIIDYINENMHNVVLSLDGRKEVN
                     DNMRPTLNDKGSYDITLPRFKKLVEKRAKDKYYYIRGTFTRDNLDFSKDVMHFADLGF
                     KLTSVEPVVGDESNPYALREEDLPKIFEEYEKFAVEYADRQLQGDGFKFFHFMIDLNQ
                     GPCVIKRITGCGAGNEYLSVTPNGDIYPCHQFVGNEEFKMANIFDEEIVLPENLKNMF
                     REAHVYTKEECKQCWNKFYCSGGCHANAINFNNDISKPYELGCEMQRKRTECSIMIQA
                     KLMLEGATN"
     gene            4483..4980
                     /locus_tag="KNP36_002950"
     CDS             4483..4980
                     /locus_tag="KNP36_002950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma carbonic anhydrase family protein"
                     /protein_id="HBF0874804.1"
                     /translation="MIRDYLEDKPLIDESVFVAKSADVIGNVKIGKDSSIWYNAVVRG
                     DEGPITIGENTNIQDCSIVHGDTETIIGNNVTVGHRSIVHGCKISDNVLIGMGSIILD
                     NAEIGEYTLIGAGTLITSNKKFPPGVLIMGSPGKVVRELTEEDKKYIDESYEWYLEAA
                     QNQKY"
     gene            5278..6942
                     /locus_tag="KNP36_002951"
     CDS             5278..6942
                     /locus_tag="KNP36_002951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AarF/ABC1/UbiB kinase family protein"
                     /protein_id="HBF0874805.1"
                     /translation="MRISYRNLKRYREIGYVLIKYGFSFIVERLNIEGIAYKIPLFDP
                     PEEIKNMTTGERMKRVLEELGPTYIKIGQILSTRKDLLDQDIIDEISKLRDDVEKFDS
                     NIAIDIFKEEVGLSIEEIFLEFKEEAIAAASIGQVYEGVLKTGEEVIVKIQRPNIEKI
                     IKSDLEILRTIANTLKDLKKDFNLDLVQMIEEFQTQLMRELDYTFEAINATKFSRIFK
                     NSDEVYIPKVYSEYNTKKILVMEKVNGTKLSDVEKIRRLGYNTKTIVEIGVRSFFTQV
                     LSHGFFHADPHPGNIFVVAKNKIAYIDFGMIGIIDNKTLNQLNEIALAGVEKNVDKII
                     YLLIEMDALNGEADIKGLRQDLLYLIHYYYDISIEKINVTDILNELFRFFRQYKIVMP
                     AQFVTLAKTVITLEGTSRTLNTDFSFGSMGKEFMKHHYKSKFNPKNVVLSSRQNVEEI
                     LLDIKTIPKQLKAILKNIERNNIKMQIEDVKMTRLENCIIELTSQISLSLVLASIIVG
                     SSLIIASPNIENNIWIKFTAIAGFFISFIIGLCLVIRSIRSKYKKD"
     gene            6955..9405
                     /gene="recJ"
                     /locus_tag="KNP36_002952"
     CDS             6955..9405
                     /gene="recJ"
                     /locus_tag="KNP36_002952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HBF0874806.1"
                     /translation="MKKWILKYKGKIEESEFSKKLNISPEICQILKNRGICTEKDSEI
                     FMNPSLDYLRDPFLMKDMQKAVDRIKLAVEKNEKIWIYGDYDVDGVSSTSILCLYFKS
                     IGYNVDYYIPNRLEEGYGINEDAIKLISSRGCDLIISVDCGITSVSEVNTANDLGIDV
                     IITDHHECQSEIPSAFAVINPKQEDCNYPFDSLCGCGVAFKMIQALTPKEEFKTSMYN
                     YLEIVTLATICDIVPLIDENRIIVKNGLKSMKEGKNIGLRELIKVCGVESDKIGSSHI
                     GFAIGPRINASGRLGYSYLGVELFTTQSQEEAVEIASILEEKNNERQMIEAKMYHEAE
                     EMLKSNSRYNDDKVLVLAKEGWQHGIIGIVASKLTEKYYKPTILLGIENGEATGSARS
                     IKGFNIFEALIKCKDLMTKFGGHEQAAGLSLDSDNVEILANEINKFADYNLTEDDMIE
                     NVNVEFELQENVINLNLVEELHKLEPFGLNNPNPRFIVRNYILKDLKVIGKNQQHLKL
                     SIEKEKSYECIGFNMSHLKSMYKVGDKVDVLFQLDENNYMGNRKVQFLLKDIRLARPK
                     SASNDKLSLKLMSKIIPKDTQSLYNISVSDFELFDGNTDINIFDYFEKDTLIISNSIN
                     GFYRAMSDISLIDLDFNINYNIIEDVSKNTDKLELIFSPNIDKIDLKRYNNIILYDYL
                     YNKGEYSYIYENKREESEIIKYYNKTDLLYLKNVVSNIVPSRDEFITIYKQALIKKEI
                     DLDMVNIRETFNVIPLKFFTILNVFRELNLLDFNLNYEKNSVLIRILPKPQKKLDLNE
                     SLILNNLKNLEKQYNSSY"
     gene            9418..9930
                     /locus_tag="KNP36_002953"
     CDS             9418..9930
                     /locus_tag="KNP36_002953"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HBF0874807.1"
                     /translation="MDLKNFIRNIDDFPKPGIDFKDVTTLFKDGDAFKYAVDSIVEEL
                     KDKDVDLVIGPEARGFLMGTPVAYALGVGFVPIRKPGKLPGEVESYEYGLEYGTDTLE
                     IHKDAIKKGQKVAIVDDLLATGGTMEAAAKLVEKLGGEVVSMQFLIELKFLNGREKLS
                     NYDVNSLIKY"
     gene            10004..12211
                     /locus_tag="KNP36_002954"
     CDS             10004..12211
                     /locus_tag="KNP36_002954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003229747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HBF0874808.1"
                     /translation="MHDKELQEIIEKIKVYAPNANFEMVEKAYNLAKKAHEGQYRKSG
                     EPYFIHPLAVANILIEMELDIETITAGLLHDVVEDTEYTYEDIKKEFGKEVADLVDGV
                     TKLGQIKYRSKEETQSENLRKMFLAMAKDIRVILIKLADRLHNMRTLKYMPPEKAKYK
                     AKETLEIYGGIAHRLGISKIKWELEDRALRFMDPEGYYDLVSRVSMKRSQREDYIQGI
                     VELLKDKFKDLSIPCDVYGRPKHFYSIYRKMQKKHKTFEEIFDLTAVRILVDNVKDCY
                     AVLGIVHTLWRPIPGRFKDYIAMPKPNMYQSLHTTVVGPDGEPLEIQIRTHEMHNIAE
                     NGIAAHWKYKEGISSKESKVEEKLQWLRQMMEWEKDLKDPQEFMDALKEDVFNSQVYV
                     FTPKGDVIELPAESTPIDFAYRVHTNVGNKCVGAKIDGRIVPIDYKLQNGNIVEVLTS
                     SNSNGPSRDWLNIVKTPNAKSRIRQFFKKERREENVDRGNTILEREFKKHDIPQKDPL
                     VEKYMALVAKKFNQPSVEDLIATVGYGGIMSSQVVSKVKDLYLKEVKKAKKEQQIQEE
                     DLNKHNISETEYSKKRKKNASQGIIVKGLDNILVRFAKCCNPLPGDEIVGYITKGRGV
                     AIHRADCPNANNNGDFFQNRLVEVSWSSAGKGKFEAEIQIKAIDRRGIVNEITHIVAM
                     DKLSLNGINARKGKDSIVSINLLVEVNDTEELKILMKKLKAIPGVESIYRMTN"
     gene            12236..12685
                     /locus_tag="KNP36_002955"
     CDS             12236..12685
                     /locus_tag="KNP36_002955"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HBF0874809.1"
                     /translation="MRAVVQRVSSSKVTVDENTIGQINKGLLVLLGVTHDDKSSDVDY
                     MIDKILNLRIFEDENDKMNLSLMDIGGELLVVSQFTLYGDCRKGRRPGFSNAARPELA
                     NNLYEEFVKKAKDKGVTVGTGQFAAHMMVELTNDGPVTILLDSSKSF"
     gene            12700..13314
                     /locus_tag="KNP36_002956"
     CDS             12700..13314
                     /locus_tag="KNP36_002956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0874810.1"
                     /translation="MIIKKFVDSYFGVNTYVLGDEKTKKCAVIDPGGSLVETLSFVKE
                     NELNIEYIILTHGHGDHIGYVKDIKEKTGAKVVAHVDEKELLNDKNKNLSYTMRCGAQ
                     EFDADIYVNDKDKLELGELKMTFLHTPGHTQGCMCIRVEDEMFTGDTLFAGSIGRTDL
                     YSGDFNQMEKSLKKLCKYEDAVRVYPGHGPTSTLGVEKKTNPYM"
     gene            13405..14961
                     /locus_tag="KNP36_002957"
     CDS             13405..14961
                     /locus_tag="KNP36_002957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="HBF0874811.1"
                     /translation="MLYVFLKGHDYKYEVAELIKLFTSEFKFKDSNANNNIESKHLIN
                     RLIYENGVLFSSTEYYENGNLKYESIQNIENMNLEFLDGFDSSKTIEEFLNSLDSESK
                     RNFKKLCKENIKKSMFLVLKQVFNSYVPWGILTGIRPVKIVHNLMDKKLDDNSIRTIL
                     KDNYFIIDEKIDLALEIAKRERLFMYPIDKNKISLYVSIPFCPTRCVYCSFPSNSLKQ
                     FGHLKREYVYKLIEEIKGFAKVIKDTKKEVETLYIGGGTPTTLDEEELDLLINSLFNE
                     LDLSKIKEFTVEAGRPDTITEQKLRVLKKHNVSRISINPQTMNDDTLVKIGREHRVSD
                     LVDCFNMARRMGFDNINMDIILGLIDEDLNMVKNTLEEIKKLSPESLTVHTLAIKRAS
                     NLNINMDRYKEHLTQYEEMVKMIDLSMKYAKDMGLNPYYMYRQKHMLGNLENIGYAKE
                     GYECIYNIQIMEEKQSNYALGAGAISKFVYVDEDRIERVENVKNVEQYIERVDEMIKR
                     KKEEVYKNVD"
     gene            14951..16213
                     /locus_tag="KNP36_002958"
     CDS             14951..16213
                     /locus_tag="KNP36_002958"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HBF0874812.1"
                     /translation="MLTKAPRGTKDITPKEAYKWRYVENKFREICALYGYEEMVTPIF
                     EHTELFKRSVGDTTDIVQKEMYSFKDKGDREITLKPEGTAGVVRAFIENKLYADTQPT
                     KLFYVTPCFRYERPQAGRQRQFHQFGIEALGSDTPSMDAEIIALAVQFFNEVGLNDLV
                     VSINSVGCPVCRKEYNALLKEYLDSKADILCDTCNERREKNPMRVIDCKNPTCKENIK
                     DIPFIADHLCDDCKSHFDKLQEYLKEMNINFVIDKTIVRGLDYYRKTAFEIISNDIGA
                     QSTVCGGGRYDGLVEQLGGPKGISGIGFGLGIERLLLTLEGNGIEIENPQSTDIFIVT
                     IGEEANTRSFKLLKDLRQNHISADKDHIERSVKAQFKYSDKINSKFTIVIGDDELKND
                     TATLKNMKTSEQTTVKLSTLVEELKQKL"
     gene            16287..18074
                     /gene="aspS"
                     /locus_tag="KNP36_002959"
     CDS             16287..18074
                     /gene="aspS"
                     /locus_tag="KNP36_002959"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HBF0874813.1"
                     /translation="METLKGLKRTHYCGELREKNINEEVVLMGWVQKKRNLGGLVFVD
                     LRDTSGLCQIVFDTDVDKEAFEKAEKLGAEFVIAVKGKVCERQSKNPNMPTGDIEIFA
                     TELRLLNKSETPPIYIKDDDDVSEALRLKYRYLDLRKPSMQRNLKLRHKVMNITRNYL
                     SNNRFCEIETPFLIAPTPEGARDYLVPSRVNPGKFYALPQSPQLYKQLLMVSGMDRYF
                     QIVKCFRDEDLRADRQPEFTQIDCEMSFVEQEDVMSMIEGLLEAIFKEVLDVELALPL
                     PKMTYAEAMSKYGSDKPDTRFGYELTDISDVVCNCGFKVFADATQPGKSVRGINVKGK
                     ADDFTRKQISSLEEHAKTYRAKGLAWMKVGQEGVTSPIAKFFNEEEMNAILTRMNAEV
                     GDLLLFVADKNSIVFDALGQVRLEVANRLNLLDKNVYNLLWVTEFPVFEEDEETGTFS
                     AMHHPFTSPMDEDLDKLEEGDKSSLRAKAYDIVLNGYEIGGGSVRISNSDVQSRMFKA
                     LGFTEERANEKFGYLLEAFKYGTPPHAGLAFGLDRLVMLLAGTDNIREVIAFPKNQNA
                     VCPMTNAPTLAEDEQLEELSIKVDIKDNE"
BASE COUNT         7405 a         1819 c         3392 g         5583 t
ORIGIN      
        1 aaatcactat aaatgagtaa taaatataaa tagtgtatac taatgggatg gaaaatgtcc
       61 actattaact ttattacccc acatatataa gataaaatta ttaatataaa atataatcta
      121 tcgacaatga atagactttt aaataaactt aatataaaat taattaaata agtgcttaaa
      181 aacgatttac tttaatgata gaatcatatt aaaggaggat aattttatgg atataaagaa
      241 taaaattaaa tctatatttt taccagaaaa aaatgactat ttagatgatg aagaatttga
      301 gtatgatata gaaaataatg aagaagattt aaaggaagat aacaaagtac atttaaatga
      361 tttaagcaga gtaaaatatg attacagaga gttaaaagac atagaaaacc aaacagaaga
      421 gatgtgtctg ctagcagtaa agcaggatgg tactataatt gagtttgtaa aggacaagac
      481 ttataaagta tgtatggaag cagtaaaaca gacatataaa tctcttaagt atataacaaa
      541 tcaaaatgag gatatttgta tagaagcagt aaaacagaac tacagagctt tgtactacat
      601 aaataataag acagaaaatg tactaattga ggctataaaa aatgcatcaa cttatgatgt
      661 catggaagta tttaaatttg tggaagagca aacagaagat gtatgtctag catttataga
      721 aagggcatct aaaaatgatg ttgcagagat attaaaagga ataaaagagc aaactccagc
      781 catatgttta gaagctgtaa aaaaagatgg aaaatcttta gcttatgtaa aggaacaaag
      841 taatagtata tgtttagaag ctgtaaaaga aaactacagt gcactatctt gtgtaaaaga
      901 gcaaactgaa gaaatatgta tagaagcagt aaaacagaat gactttgcat tgtattatgt
      961 aaatgaacag acagaaaaaa tatgcatgga agcagtaaaa agaagttata tggctctaca
     1021 gtatgtaaat aagcaaacag aagagatttg tttggaagca gtaagaattg atggaagagc
     1081 attacagtac gtaaaagagc aaacagaaga aatttgcttg gagtcagtta gacaaaatgg
     1141 aaaagtactg caatatgtaa aaaaacagac tgaaaatata tgtatagaag cagtaagagg
     1201 ttcatttgaa gaacttgaaa taaaagaaat attaagttat gtaaagatac caacagaaag
     1261 aatatttgta gaagcagtaa agcaaaatgg aaaaattctt aaatatgtag aaaatcagac
     1321 agaattaata tgtttagagg cagtaagaga aaactataat gctttagctt atgtaaagga
     1381 acaaacagaa aagatttgtt tagaagcagt taatcaaagt tatgaagcgc ttaaatatgt
     1441 gaaagaacaa acagaagaag tttgtctaaa agcagtaaaa caagattata gaatgttgaa
     1501 atatgtaaat aatcaaacag aaaaaatatg tttagaagca gtaaagcaaa attatagagc
     1561 tttagaattt gttgataatc aaacagaaaa agtttgtctt gaagcagtaa aacagaatag
     1621 aaaagcacta cagtatgtaa aacaaaaaca aagttaaaag gctaaaatat atggggaata
     1681 tatgcaaata aataaaattt gatattttgt aataaataaa atgggtatct caaaaggaac
     1741 tttttagttt gtgaggtact ctttttatat gaaatgaaat atatttttag ccttttaaca
     1801 aaggggaaaa ggtttgtttc tattttgaca taggcttttt atgcatataa agcttgataa
     1861 aattgtttta ttataattgt tttgttatat aaataataag aagaaaatta tataggtctt
     1921 tttttgacca gttttacatt tttaacaact agttttgtaa agtatattga attttctcaa
     1981 aaaagaatgt actctatata tgtaaaattt ttttggaggt aaaaatgttt aaaagatatg
     2041 ctgaaaaaat gacatctgtt ttaatttgta ataatatgat agataataat gaatctaaag
     2101 tctattctta tggatttgaa atattaatag ctttcatagt taatataacc accatgctgt
     2161 ttataggttt tttatttggt aaatttacat atgtattatt ttttttaatg tgttattgtc
     2221 caataagaca attttcagga gggtatcatg cagacaatta ttttagatgc ttattaactt
     2281 ttatttttat aattttatcc acaatcttaa ttatagaaaa tataaatata gacttattta
     2341 aaaatattat tatgattatt gcaagtgtta gttgggttgg aatttgtgtt ctgtgcccaa
     2401 tagaacatag gagtaaccct ataagtgata gggaaaagtt ggtttataag aaaactgcta
     2461 tatttatatc tacagtagtg ttattgataa caatttcaag tctttctttg agtatatttg
     2521 tagattattt cacatatagc gcatttgcca tgttttggat ttttgtgatg ttagtattag
     2581 gtaagttaaa agctaaagta taagtaaaat atgtatgagg gagagttaag ttatgaaaaa
     2641 gtttattgta agatttatga agtttgctag ctcattggca cttagcactg ctattttgtc
     2701 agctaatagt acctgtcctt ggattattca tcagcctaaa gtacccaaag aaatcagcaa
     2761 tctaaagaag acaaattaaa tacaagcact tatttataca aaattatcag gaaaaaagaa
     2821 attattatat tttaataaga ttaaaacaat ataaaatcag atacaaaatt tattttatag
     2881 gagcctaata cctatttggt aatatattag tgcgccaatt tagggggata tagtgtattt
     2941 aatgaaatga cttacggaga gtaagtcatt tttgtattgt atgtatttta tgtaaactta
     3001 tgatataatg aagggtaaag tttaattaaa ataataaaaa actttagtat agatagtaat
     3061 ttaggaggta gggtatgagt atgatacata aattttctat gaatggatat aatatcgttt
     3121 tagatgtgaa tggtggagct gttcatgtgt tagatgatgt tgcatacgat ttgttagatt
     3181 tttataaaga aaaaagtaaa gaagaaatat tagagatatt aaaatcaaaa tatcaagaag
     3241 aaaaaataaa tgaagcatat gaagaaatat taaatttgga aaaagagggt cttttatata
     3301 cagaagatac atatcaatat catccaagct ttgtacatag agagcctgta gtaaaagctt
     3361 tatgtttaaa tgtagctcat gattgtaact taaaatgtaa atactgtttt gcagctcaag
     3421 gtgattttgg aggagaaaaa gaacttatga gttttgaagt tggtaaggca gcaattgact
     3481 atttgattgc taattcagga agtagaaaga acctagagat agatttcttt ggtggagagc
     3541 ctttgatgaa ctttgaagtt gtaaaacaac tggttgacta tggaagaagt gtagaaaaag
     3601 attataataa aaatataaga tttacaataa ctacaaatgg tgtactgcta aatgatgaga
     3661 ttatagatta tataaatgaa aatatgcata atgtagtttt aagtttagat ggaagaaaag
     3721 aagttaatga taatatgaga ccaactttaa atgataaagg aagttatgat attacattac
     3781 cacgatttaa gaaacttgtg gaaaaaagag caaaagataa gtattattat ataagaggta
     3841 cttttacaag agataattta gatttttcaa aagatgttat gcattttgca gatttaggat
     3901 ttaaattaac ctctgtagag ccagtcgttg gagatgagag taatccatat gcacttagag
     3961 aagaagattt acctaagata tttgaagagt acgaaaaatt tgctgtagag tatgcagata
     4021 gacaattaca aggagatgga tttaaatttt tccattttat gatagaccta aatcaaggtc
     4081 catgtgtaat aaagagaata actggatgtg gagctggaaa tgagtatctt tctgtaactc
     4141 caaatggaga tatctatcca tgtcatcaat ttgttggaaa tgaagaattt aaaatggcaa
     4201 atatatttga tgaagaaata gtacttccag aaaatttaaa aaatatgttt agagaagctc
     4261 atgtatatac taaagaagag tgtaaacaat gttggaataa gttttactgt tcaggtggat
     4321 gtcatgcaaa tgcgataaac tttaataatg acatatcaaa accatatgaa ttaggatgtg
     4381 aaatgcaaag aaaacgtaca gagtgctcta taatgataca agctaagtta atgttagaag
     4441 gagcaaccaa ctaaatttat attttaaagg agttgtttat atatgattag agattattta
     4501 gaagataaac ctttaattga cgaaagtgta tttgtggcaa aatcagcaga tgtaattgga
     4561 aatgttaaaa taggcaaaga ttcaagtata tggtacaatg cagtagttag gggtgatgaa
     4621 ggaccaataa ctattggaga aaacactaat atacaagatt gttctatagt gcatggagat
     4681 acagaaacta taattggtaa caatgtaaca gttgggcata ggtctatagt tcatggttgt
     4741 aaaattagtg ataatgtgtt aattggtatg ggttcaataa tattggataa tgctgaaata
     4801 ggagaatata ctctgatagg agcaggtaca ctaattacat ctaataagaa gtttccgcca
     4861 ggtgttttga taatgggttc tcctggtaag gttgttagag agcttacaga agaagataaa
     4921 aaatatattg atgaatctta tgaatggtat ttagaggcag cacaaaatca aaaatattag
     4981 tttaaagagt ggttgtttca aaacatattt aaatctgttt tgaggcaacc actaatttat
     5041 tttattagat tttgttgata ttttagtttt caaaaagtat ttgattaaac cagatataaa
     5101 atgtcaaaaa taaaaattaa ctgagttaaa taattttaat aaaattggta gtatatgtga
     5161 taaaattaaa tattaaagag gatataggat attagaatat caattggtga aataatgtca
     5221 tatacgataa attaaggtgt aagtttttgg gtatacctat cttaggagtg aaaagatttg
     5281 agaataagtt atagaaattt aaagcgatat agagaaattg gatatgtttt aataaagtat
     5341 ggttttagtt ttattgtaga aagactaaat atagaaggaa ttgcctataa aataccacta
     5401 tttgacccac cagaagaaat aaaaaatatg acaactggtg agagaatgaa aagagtttta
     5461 gaagaactag gacctacata tataaaaata ggacagatat tgagtacaag aaaagacttg
     5521 ttagaccagg atataattga tgaaatatca aaactcagag atgatgtaga gaaatttgat
     5581 tcaaatatag ctattgatat atttaaagaa gaagtgggtt taagtataga agaaatattc
     5641 ttagaattta aagaagaagc aatagcagca gcttcaattg gtcaagttta tgaaggtgta
     5701 cttaaaacgg gagaagaagt aatcgtaaaa attcaaagac caaatataga gaaaataata
     5761 aaatctgatt tagagattct tagaactatt gcaaatactt taaaagattt aaaaaaggat
     5821 tttaatttag atttagtaca gatgattgaa gaatttcaaa ctcaattaat gagggaactt
     5881 gattatacat ttgaagctat aaatgcaact aaattctcta ggatatttaa aaatagtgat
     5941 gaagtatata tacctaaagt atattcagaa tataatacta agaaaatttt agtaatggag
     6001 aaagttaatg gtacaaagtt aagtgatgta gaaaaaataa ggagactagg ttataacaca
     6061 aaaactattg ttgaaatagg cgttaggtca ttttttacac aggtattatc tcatggattt
     6121 tttcatgcag acccacatcc aggtaatata ttcgtagttg ctaaaaataa gatagcatat
     6181 atagattttg gaatgattgg aattattgat aataaaactt taaaccaatt aaatgaaatt
     6241 gcattagcag gtgtagaaaa gaatgttgac aagataatat atctattgat agaaatggat
     6301 gcattaaatg gagaggctga tattaaggga cttagacagg atttacttta tctaatacat
     6361 tattactatg atatttctat agaaaaaata aatgtaacag atatattaaa tgaactattt
     6421 aggtttttta gacagtataa aatagtcatg cctgcacaat ttgtaactct tgcaaagaca
     6481 gttataacat tagaaggaac aagtagaact ttaaacacag atttttcttt tggttctatg
     6541 ggaaaagagt ttatgaaaca tcattataag agtaaattta accctaaaaa tgttgtttta
     6601 agttcaagac aaaatgtaga agaaatatta ctggacataa aaactattcc aaagcaatta
     6661 aaagcaattt taaaaaatat agaaagaaat aatataaaaa tgcaaattga agatgttaaa
     6721 atgacgaggt tagaaaattg tataatagag ctaacatctc aaatatcttt gagtttagtg
     6781 ttggcatcta ttatagtagg ttcttctctt ataattgcat ctccaaatat agaaaataat
     6841 atatggataa aatttactgc aatagcgggt ttctttatat cctttataat aggcctttgc
     6901 ttagttataa gaagtattag gtcaaaatac aaaaaagatt agggggaatt aaatttgaaa
     6961 aaatggatat tgaagtataa aggtaagata gaggaaagtg aatttagcaa aaaacttaat
     7021 atttccccgg aaatctgcca aattttaaaa aatagaggga tatgtactga aaaagattca
     7081 gagatattta tgaatccatc tttagattat ttaagagacc cttttttaat gaaagatatg
     7141 caaaaagctg ttgatagaat aaagttagca gttgagaaga acgaaaaaat ttggatttac
     7201 ggagattatg atgttgatgg tgtatcatct acatctatct tgtgcttata ttttaagagt
     7261 ataggttaca atgttgatta ctatattcct aatagattag aagaagggta tggtataaat
     7321 gaagatgcta ttaagcttat aagctctagg ggatgtgact tgattataag tgttgactgt
     7381 ggaattacat cagtgtctga ggtcaataca gcgaatgatt tgggcataga tgttataatt
     7441 acagaccatc atgaatgtca aagtgaaatt ccatcagcct ttgcagtaat aaatccaaaa
     7501 caagaagatt gtaattatcc atttgattca ctatgtggat gtggtgtagc atttaaaatg
     7561 attcaagcct tgactccaaa agaagaattt aaaactagta tgtataatta tttggaaata
     7621 gtaacactag caactatttg tgatattgtt ccacttatag atgaaaatag aataattgta
     7681 aaaaatggtt taaaatcaat gaaagaaggc aaaaatattg gattaaggga gcttataaaa
     7741 gtttgtggtg tagaaagtga taagataggt tcttctcata taggttttgc aataggtcct
     7801 aggataaatg cttcaggtcg attgggatat tcttacttag gagtagagct atttactact
     7861 caatcacaag aagaggcagt agaaatagct agtatattgg aagaaaaaaa taatgaaaga
     7921 cagatgatag aagctaagat gtatcatgaa gctgaggaaa tgctaaagtc taatagcaga
     7981 tacaatgatg acaaggtgtt ggttttagct aaagagggtt ggcaacatgg aataatagga
     8041 attgtagcat caaagttaac tgaaaaatac tacaaaccaa caattcttct aggtatagaa
     8101 aatggggagg ctactggttc agcgaggtca ataaaaggat ttaatatatt tgaagctctc
     8161 ataaagtgca aagacttgat gactaagttt ggtggtcatg aacaagcagc agggttatcc
     8221 ttggattcag acaatgtaga aattttagca aatgaaataa ataaatttgc agattataat
     8281 ttaactgaag atgatatgat agagaatgta aatgttgagt ttgaattaca agaaaatgta
     8341 ataaatttaa atcttgtaga agaattacat aagttagaac cctttggatt aaataatcct
     8401 aatcctagat ttatagttag aaattatatt ttaaaagatt tgaaagttat aggtaagaat
     8461 caacaacatc tgaaattaag catagaaaaa gagaaaagct atgaatgtat aggatttaat
     8521 atgagtcatt taaaatcaat gtataaagta ggagacaagg tagatgtact attccaatta
     8581 gatgaaaata actatatggg aaataggaaa gtacaatttt tacttaaaga tatacgattg
     8641 gctcgaccta aaagtgcaag taatgacaaa ctttcattga aattaatgtc aaaaataata
     8701 ccaaaagata ctcaaagcct gtataatata tctgtgtctg attttgaatt atttgatgga
     8761 aatacagata taaatatatt tgattatttt gaaaaagata cactaataat atctaattct
     8821 ataaatggat tttatagagc aatgtcagat atatcactta tagatttgga ttttaacata
     8881 aattacaata ttattgaaga tgttagcaaa aatactgata aattagagct tatattttct
     8941 cctaatattg ataaaataga cttaaaaaga tataataata ttattcttta tgattattta
     9001 tacaataaag gcgaatattc gtatatatat gagaataaaa gagaagaaag tgaaattata
     9061 aaatattata ataaaacaga cctattatat ttaaagaatg tagttagtaa tatagttcca
     9121 tcaagagatg aatttataac aatttataaa caagcactca taaaaaaaga aattgatttg
     9181 gatatggtaa atataaggga aacttttaat gtaattccat taaagttttt tacgatatta
     9241 aatgtattta gagaattaaa tttacttgac tttaatttaa attatgaaaa aaattctgta
     9301 ctcataagaa tattgccaaa accacagaaa aaattagact taaatgagag tttaatactc
     9361 aataatctaa aaaatttaga aaaacaatac aatagcagtt attaggaggc gtttcccatg
     9421 gatttaaaaa actttataag gaatattgat gatttcccaa agccaggcat agattttaaa
     9481 gatgtgacaa ctctatttaa agatggagat gcatttaaat atgcagtgga ttctatagtt
     9541 gaagaattga aagataaaga tgtagattta gtaataggac cagaagcaag aggatttttg
     9601 atgggtacac ctgtagcata tgctttagga gtaggatttg ttccaattag aaaacctgga
     9661 aagttaccag gtgaagttga gagttatgag tatggattag agtatggtac agatacttta
     9721 gagatacata aggatgcaat taaaaagggt caaaaagtag caatagtaga tgatttattg
     9781 gctactggtg gaactatgga agccgctgcc aagcttgtag aaaaattagg tggagaagta
     9841 gtttctatgc aatttttgat tgagctaaaa ttcttaaatg ggagagaaaa gttgtctaac
     9901 tatgatgtta attctcttat aaaatactag tacttttata atagttggta taacaccaac
     9961 tattttcata tatattaaaa ttttatacaa aataggtggt tatatgcatg ataaagaatt
    10021 acaagaaata attgaaaaaa taaaagttta tgcacctaat gcaaattttg aaatggttga
    10081 aaaagcctat aatcttgcaa aaaaagcgca tgaaggacaa tatagaaaat ctggggaacc
    10141 atactttatt catccattag cagttgcaaa tattttaata gagatggaat tagatattga
    10201 aactataaca gcaggtttac ttcatgatgt tgtagaagat acagaatata cctatgaaga
    10261 cataaaaaaa gaatttggca aagaagtagc ggatttggtt gatggagtaa ctaaacttgg
    10321 tcaaataaaa tatcgttcga aagaagaaac tcaatctgaa aatttaagaa aaatgttttt
    10381 ggcaatggcg aaggatataa gggttatact tataaaactt gctgatagat tgcacaacat
    10441 gagaacatta aaatacatgc ctccagaaaa agcaaagtat aaagcaaaag agacacttga
    10501 aatttatggt ggtatagctc atagattagg aatttccaag ataaagtggg aactagaaga
    10561 cagagcatta agatttatgg acccagaagg gtattatgat ttagttagta gagtatcaat
    10621 gaagagaagt caaagagagg attatattca aggaattgtt gaacttctta aagataagtt
    10681 taaagattta agtataccat gtgatgtata tggtagacca aagcattttt acagtatata
    10741 tagaaagatg caaaaaaaac ataagacttt tgaagagatt tttgatttaa cagcagtaag
    10801 gatattggtt gataatgtaa aggattgcta tgcagtactt ggtatagttc atacattatg
    10861 gagacctatt ccaggaagat ttaaagatta tatagcaatg ccaaaaccca atatgtatca
    10921 atcattacac accactgttg taggtcctga tggagaacct ttagagatac aaataagaac
    10981 tcatgagatg cataatatag ctgaaaatgg tatagcagcc cattggaaat ataaagaagg
    11041 tatctctagc aaagaatcaa aggttgaaga aaaacttcaa tggttgagac agatgatgga
    11101 gtgggaaaaa gatttaaaag acccacaaga gtttatggat gcacttaaag aagatgtatt
    11161 taatagtcaa gtttatgtat ttacgccaaa aggagacgta attgaattac cagcagaatc
    11221 aacacctata gattttgcct atagggttca tacaaatgta ggcaataaat gtgtaggagc
    11281 taaaattgat ggaagaatag ttcctattga ttataagctt caaaatggta atattgtcga
    11341 ggtacttaca tcatctaatt ctaatggacc aagtagggat tggcttaata tagtgaagac
    11401 cccaaatgca aaaagtagaa ttagacaatt tttcaagaag gaaagaagag aagaaaatgt
    11461 tgaccgtgga aatacaatat tagaaagaga atttaagaag catgatatac cacaaaaaga
    11521 ccctcttgtt gaaaaatata tggcattagt tgctaagaaa tttaatcagc caagtgttga
    11581 ggacttaatt gccactgtag gttatggtgg tataatgtca tctcaagtgg tatctaaggt
    11641 aaaagaccta tatttaaaag aggttaaaaa agctaaaaag gaacaacaga tacaagaaga
    11701 agatttaaat aaacacaata taagtgaaac agaatacagt aaaaagagaa agaaaaacgc
    11761 atcacaagga attatagtaa aagggcttga caatatctta gtaagatttg ctaagtgttg
    11821 taatcctctt ccaggagatg aaattgtagg atatattact aagggtaggg gagtagccat
    11881 acacagagct gattgcccaa atgcaaacaa taatggtgat ttcttccaaa atagattggt
    11941 ggaggtttca tggagttcag caggaaaagg taagtttgaa gcggaaattc aaataaaagc
    12001 tattgataga agaggaattg ttaatgaaat aactcatatt gttgcaatgg ataaacttag
    12061 tttaaacgga ataaatgcaa gaaaaggtaa ggatagtatt gtaagtataa acttacttgt
    12121 agaggttaat gacacagagg aattaaaaat tctaatgaaa aaattaaaag caattcctgg
    12181 tgtagaaagt atttatagaa tgacaaatta gagttaaaat aatagggagg aaactatgag
    12241 agcagtagtg caaagagtat cttcatctaa agttacagta gatgaaaaca ctataggtca
    12301 aataaataag gggttactag tattgttagg agtgactcat gatgataaat caagtgatgt
    12361 agattatatg attgataaaa tattgaatct gagaattttt gaagatgaaa atgacaagat
    12421 gaatttatct ctaatggata taggtggaga gcttttagta gtatctcaat ttactttata
    12481 tggagattgc agaaaaggaa gaagacctgg atttagtaat gcagctaggc cagaacttgc
    12541 aaataacctt tatgaagaat ttgtaaaaaa agcaaaagat aaaggtgtga cagttggtac
    12601 aggtcaattt gcagctcata tgatggtaga gttaactaat gatggtccag taacaatact
    12661 attagactca agtaaatctt tttaaggggg aaaactttaa tgattataaa aaaatttgta
    12721 gatagttatt ttggagtaaa tacttatgta ttaggtgatg aaaagactaa aaaatgtgca
    12781 gttatagacc caggtggaag tttagtagag acattaagtt ttgtaaaaga aaatgaatta
    12841 aatattgaat atattatcct tactcatggg catggagacc atataggata tgttaaggat
    12901 attaaagaaa aaactggtgc taaagtagtt gcacatgttg atgaaaaaga attattaaat
    12961 gacaaaaata aaaatctaag ttatacaatg agatgtggag cgcaagagtt tgatgcagat
    13021 atctatgtaa atgataaaga caagcttgaa cttggtgaat taaaaatgac tttcttgcat
    13081 actccaggac atactcaagg atgtatgtgt ataagagttg aagatgaaat gttcacagga
    13141 gatactttgt ttgctggaag tattggtaga actgatttat atagtggaga ctttaaccaa
    13201 atggaaaaat cacttaagaa attatgtaaa tatgaagatg ctgttagagt atatcctgga
    13261 catggaccaa ccagtactct aggggttgaa aagaagacaa atccttacat gtaattttat
    13321 attagtattt aaaaaagtat aaaatattta ataactatat tagtgagggg gttcttctac
    13381 tgttaaatag aaggagttaa gttgatgttg tatgtttttt taaaaggaca tgattataag
    13441 tatgaagtag cagaacttat aaaattgttt actagtgaat ttaagtttaa agactctaat
    13501 gctaacaata atatagagtc aaagcattta ataaatagat tgatttatga gaatggtgta
    13561 ttattctcaa gtactgaata ctatgaaaat ggaaacttaa agtacgagtc aatacagaat
    13621 atagaaaata tgaatcttga atttttagat ggatttgata gcagcaaaac gattgaagaa
    13681 tttcttaata gcctagatag tgaaagtaag aggaacttta aaaagctgtg taaagaaaat
    13741 atcaaaaaaa gcatgttttt agtgcttaaa caagtattta attcttatgt accatgggga
    13801 attttgactg gtattagacc agtcaaaatt gtccacaatt taatggataa aaagctagat
    13861 gataatagca taagaaccat tctaaaagat aattatttta taatagatga gaaaatagat
    13921 ttagctcttg aaatagctaa aagagagcga ttatttatgt atcctataga taaaaataaa
    13981 atttctcttt atgtaagtat tccattttgt ccaactagat gtgtatattg ttcatttcct
    14041 tcaaattcat taaaacaatt tggacattta aaaagagaat atgtttataa attgattgaa
    14101 gaaattaagg ggtttgccaa agttattaag gatactaaga aagaagttga aactctatat
    14161 attggtggtg gaactccaac tacacttgat gaggaagaat tggatttgct tataaattca
    14221 ttgttcaatg aattagattt aagtaaaatt aaagaattta ctgtagaagc aggtagacct
    14281 gacactatta cagaacaaaa actaagagtg ttaaaaaaac acaatgttag tagaattagt
    14341 ataaatcctc aaactatgaa tgatgatacc ttggtaaaga ttggaagaga gcatagagta
    14401 tctgatttag tagattgctt taatatggct cgtagaatgg gatttgataa tataaatatg
    14461 gatataattt taggtcttat agatgaagac ttaaatatgg taaagaacac attggaggag
    14521 ataaaaaaac tttctcctga aagccttaca gttcatacat tagccataaa gagagcatct
    14581 aacttaaata taaatatgga taggtataaa gaacatctaa cacaatatga agaaatggta
    14641 aaaatgatag atttatcaat gaaatatgca aaagatatgg gattaaatcc atattatatg
    14701 tacagacaaa aacatatgtt gggaaattta gaaaatatag gttatgctaa agaaggatat
    14761 gagtgcattt ataatataca gattatggaa gaaaaacaaa gtaactatgc attaggtgca
    14821 ggtgctatat cgaaatttgt ctatgtagat gaagatagaa ttgaaagagt agaaaatgta
    14881 aaaaatgttg aacaatacat tgaaagagta gatgaaatga taaaaaggaa gaaagaagag
    14941 gtatataaaa atgttgacta aagctcctag aggaactaaa gacataactc caaaagaggc
    15001 ttacaaatgg cgttatgtag aaaataaatt tagagaaata tgtgctttat atggatatga
    15061 agaaatggta acacctatat ttgaacatac agaacttttc aagagaagtg ttggagatac
    15121 tacagatata gttcaaaaag aaatgtattc ttttaaagat aaaggtgata gagaaattac
    15181 cctaaagcca gaaggtacag caggtgtagt aagagcattt atagaaaata aattatatgc
    15241 agatactcaa ccaacaaaat tattttatgt gacaccttgt tttagatatg aaagaccaca
    15301 agctggtaga caaagacaat ttcaccaatt tggaatagaa gcacttggaa gtgatactcc
    15361 ttcaatggat gctgaaataa tcgcactagc tgttcaattt tttaatgaag ttggattaaa
    15421 tgatttggta gtgagtataa attcagttgg ctgtccagtt tgtagaaaag agtacaatgc
    15481 tttattaaaa gagtatcttg actcaaaagc tgatatattg tgtgatactt gcaatgagag
    15541 aagagaaaaa aatccaatga gggttataga ctgtaaaaat cctacatgta aagaaaatat
    15601 caaagatata ccatttattg cagaccattt gtgtgatgat tgtaaatctc actttgataa
    15661 acttcaagaa tacttaaagg aaatgaatat aaactttgta attgataaaa caatagttag
    15721 aggcttagat tactatagaa aaactgcttt tgaaattata tctaatgata taggagctca
    15781 aagtactgta tgtggtggag gaagatatga tggtcttgtt gaacaattag gaggaccaaa
    15841 aggtataagt ggaattgggt ttggactagg aattgaaaga cttttactta cacttgaagg
    15901 taatggaatt gaaatagaaa accctcaatc tacggatata tttatagtaa ctataggtga
    15961 agaagcaaat acaagaagct ttaaattgtt aaaagacttg agacaaaatc atataagtgc
    16021 agataaagac catatagaga gaagtgttaa agcacaattt aaatattcag ataaaataaa
    16081 ttcaaaattt acaatagtaa ttggagatga tgaacttaaa aatgacactg cgacattaaa
    16141 aaatatgaaa acatcagagc aaactactgt aaaattaagt acattagttg aagaattaaa
    16201 gcaaaagctg taaaataaga aagtatgatg ttttgtgtat tagataaata tatagcatta
    16261 aaattaaata aaatggaggt agtatcttgg aaactttaaa gggtttaaag agaactcact
    16321 actgtggaga gttgagagaa aaaaacataa atgaagaagt cgtacttatg ggatgggtac
    16381 agaaaaaaag aaatttaggt ggtcttgtat ttgttgattt aagagataca agtggattat
    16441 gtcaaatagt ttttgataca gatgtagata aagaagcttt tgaaaaagct gaaaaattag
    16501 gggctgaatt tgtaatagct gtaaaaggaa aagtatgcga aagacaatct aaaaacccta
    16561 atatgccaac tggtgatata gaaatatttg caactgaact tagactttta aacaagtcag
    16621 aaactccgcc tatttatata aaagatgatg atgatgtttc tgaagcacta agattaaaat
    16681 atagatactt agatttaaga aaaccatcta tgcaaagaaa tttaaaatta agacataaag
    16741 taatgaatat tacaagaaat tacttatcaa acaatagatt ttgcgaaata gaaacaccat
    16801 ttttaatagc tccaacacca gaaggagcaa gagattatct agtaccaagt agagttaatc
    16861 caggaaaatt ttacgcatta ccacaatcac cacaattata taaacaatta ttgatggtaa
    16921 gtggtatgga tagatatttc caaatagtta aatgctttag agatgaagac ttaagagcag
    16981 atagacaacc agagtttaca caaatagact gcgaaatgtc ttttgttgag caagaagatg
    17041 ttatgagtat gattgaaggt ttgcttgaag cgatatttaa agaagtttta gatgtagaat
    17101 tggcacttcc acttcctaag atgacttatg cagaagctat gtctaaatat ggttcagata
    17161 aaccagatac tagatttggg tatgagttaa cagatatatc tgatgttgtt tgtaactgtg
    17221 gatttaaagt gtttgctgat gctacacaac caggaaaaag tgttagaggt ataaacgtaa
    17281 aaggcaaagc tgacgacttt actagaaaac aaatatcatc actagaagaa catgctaaga
    17341 catatagagc aaaaggtctt gcttggatga aagtaggaca agaaggagta acttctccaa
    17401 tagcaaaatt cttcaatgaa gaagaaatga acgctatact tacaagaatg aatgctgaag
    17461 taggagattt acttttattt gtagctgata aaaactcaat agtatttgat gctttaggac
    17521 aagttagact tgaagtagca aataggctta atctattgga taaaaatgta tataacttac
    17581 tatgggtaac tgagttccca gtttttgaag aagatgaaga aacaggcaca ttctcagcaa
    17641 tgcatcaccc atttacatca cctatggatg aagatttaga caagttagaa gaaggtgata
    17701 agtcatcttt aagagcgaaa gcttatgata ttgtattgaa tggttatgaa ataggtggag
    17761 gaagtgttag aatatcaaat tctgatgttc aatcaagaat gtttaaagca cttggtttta
    17821 cagaggaaag agctaatgaa aagtttggtt atttattaga agcatttaaa tatggtactc
    17881 ctcctcatgc tggtctagct tttggtcttg atagacttgt tatgttactt gcaggaactg
    17941 ataatataag agaagttatt gcattcccta aaaatcaaaa tgctgtttgc cctatgacaa
    18001 atgctcctac attggcggaa gatgagcaat tagaagaatt aagtataaaa gttgatataa
    18061 aagataatga ataatatgta gttgcaagaa actaaaatgt aaaaagtctg gatataaaat
    18121 atatttatat tcagactttt tttattagaa ttattttata ttttttctct atatattttc
    18181 ataaattata cttatattc
//
LOCUS       DAEHWM010000090        18076 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.091, whole genome shotgun sequence.
ACCESSION   DAEHWM010000090 DAEHWM010000000
VERSION     DAEHWM010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18076)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18076)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18076
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.091"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(194..1624)
                     /gene="dcm"
                     /locus_tag="KNP36_002960"
     CDS             complement(194..1624)
                     /gene="dcm"
                     /locus_tag="KNP36_002960"
                     /EC_number="2.1.1.37"
                     /inference="COORDINATES: protein motif:HMM:NF024835.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007157505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /protein_id="HBF0874814.1"
                     /translation="MKKITIDKNRVRKIMKEKNIRSQNQLALNMGITKNQLSAILSEK
                     FTPIKSNVEKLCEVLDIGFDEIMCLEDVNEKQLKFTNICSSNKDYIEHRDCTYKELSE
                     YELNPRERNKNNKHIDISNVLAKRAYTCVELFAGAGGLALGLEKAGFKEVGLVEWDKY
                     ACDTLKLNRPDWNVIQGDIVKIAENGIKNYIDNNIEIDLLSGGYPCQAFSYAGKKLGL
                     EDVRGTLFYSYAKILEELKPKVFLAENVRGLVSHDGGKTLKTMIDVFSEIGYNVKYEI
                     LKAVNYGVAQKRERVIIIGTRKDLSHVDFKFPKSFEYVATLRDALKNVPKSEGARYPE
                     RKKKVLDMVPPGGCWIDLPDEVARDYMGKSYYSGGGKRGMARRISWDEPCLTLTCSPA
                     QKQTERCHPDETRPFTTREYARIQSFPDEWEFTGSVSQVYKQIGNAVPVKLGKAIGLS
                     IVDYLNKIEKIYVTEEVAITEEEYVI"
     gene            1837..2553
                     /locus_tag="KNP36_002961"
     CDS             1837..2553
                     /locus_tag="KNP36_002961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002601887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease"
                     /protein_id="HBF0874815.1"
                     /translation="MTELEKQEILDKAKDFFTNILVANHKKNTIKLNLKAFNINPFLV
                     KYLASFLTGSNKPEDIAKALIYPRVLGTSINTSFGTNLQKFCITTLDGFASTTSGIDI
                     EFIDCIDGRRKFCQIKAGPNTINKDDVKTIIDHFSSVKRLARTNGLSLSYNDLIVGVF
                     YGTENELNAHYKRINEEYPVVVGQDFWYRLTGDENFYFDLIDTIAQSALEEDCTVLLK
                     KTISNLADEISKDKSLFNQK"
     gene            complement(2798..3076)
                     /locus_tag="KNP36_002962"
     CDS             complement(2798..3076)
                     /locus_tag="KNP36_002962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874816.1"
                     /translation="MYDEIIEIYFDYWINEHMYRKVLEKDEYYNDRCKEIKKVNKLLE
                     KNLSEEKKMDVLIELNDLFNSVIEIERELGYKLGFKAGARFMIELLNS"
     gene            complement(3324..4658)
                     /locus_tag="KNP36_002963"
     CDS             complement(3324..4658)
                     /locus_tag="KNP36_002963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0874817.1"
                     /translation="MDNMSNLVKNTEAEQSILGSILLDSRKIEEIEILISEDMFYHQE
                     HKHIFNSVKDIHKRDEPIDIITLTEDLKKKGLIDYVGGISYLTKLSTIVPTIGNVSHY
                     IEIVIEKYKNRNIIDKFNKFKLGEIDDNTLIYQLEKYVNEVNQKLVKKDSSITAISER
                     AFEYINDEIEEGIDIGIKFLDETIGGLYSGELITIAAKSGRGKTALALQIMRNVVFQG
                     KKVLFISGEMSDIQILFRNIASLTGISVVKMKNRNLNEEEIIKYINALSTLNQENNLY
                     INDSVNTISGIKREIKSIKPDVVIIDYLQILDYEGKEVGEAKFADLSRQIKKITLDFN
                     IPIIQLAQLNDELKDERPKGDRVMRSSKQIYMDSNSVIYIHRPTEKEALDYCKTMGIE
                     DIKELRRREKGFGANLSEIIVAKNRDGESGFRPYWYIGSLFSFKECKKVKEV"
     gene            complement(4671..5414)
                     /locus_tag="KNP36_002964"
     CDS             complement(4671..5414)
                     /locus_tag="KNP36_002964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874818.1"
                     /translation="MSNLGWIKLHRKIKESPLYKDCNSKQRDILINLLLSVNHKPNKW
                     VYGGKEYEVKSGQLITSLESIANMCSKDVSIQNVRTALKKFERYGFLTNKSTNKNRLI
                     TIENWELYQSNEENQQTNQHAINKQLTTNKNVNNEKSKIYSEIIEKFNITCTELSKVK
                     KLTEARKKVINARIKEYDKETVLEIIHIVSKTSFLNGSNEKGWKANFDWIMSPNNFIK
                     ILEGNYQDKSINVKVDAEAYSPDDSQLKW"
     gene            complement(5435..5749)
                     /locus_tag="KNP36_002965"
     CDS             complement(5435..5749)
                     /locus_tag="KNP36_002965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874819.1"
                     /translation="MADTNNLEVLKTLQATLNILVKQEQEAQEKEKGYKEIQTYRRDK
                     AQLITCKEASKIYPIGESKFRQLCHSKNKGFPCIWIDNRVYIIKNKLDNWFIENANGI
                     KL"
     gene            complement(5753..5947)
                     /locus_tag="KNP36_002966"
     CDS             complement(5753..5947)
                     /locus_tag="KNP36_002966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003450825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874820.1"
                     /translation="MKLKLKRIEKGIKQYELAEKVGISRYYLSSLERGKSKNPSNMLM
                     LKLAQELDTSVEELFFDKEE"
     gene            6231..6947
                     /locus_tag="KNP36_002967"
     CDS             6231..6947
                     /locus_tag="KNP36_002967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0874821.1"
                     /translation="MIKKISTALSIPINRLIIDESDLDTSTNNYTNLKELDLVVKTFD
                     NYSAKLIGNNISKFRNINNISLKELSEKINCSENEIINYENGTKMPRIEILKKIALAT
                     YTKIEDLFGFPLEEIKIDNQTILYRNPQTGYIIDNFLIDFINKDINIDNTPVSYYIDK
                     SEFDLVIHILKNYGYDVKTDYKTKFEIADNADTIKPISLSFSDFKDFSKNLNWVINGL
                     VENFIQENSNGLIEDEDEEY"
     gene            7044..7796
                     /locus_tag="KNP36_002968"
     CDS             7044..7796
                     /locus_tag="KNP36_002968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBF0874822.1"
                     /translation="MNKSYIPKYTHKFPTNLPHGDKKYTLTYIRRMISEFVYDMGNLE
                     NNPFTFPEVQTLLDGITVGGHKLSDQNQILNIKSSWDYVIKLSNKENLSLNKDTICSI
                     HKIVAKDEALIVGDFRNGNIGIAGTTQYECIEATLLNDLFVSDINIINKITNPLEKAI
                     IINLWLSYCQFFYDGNKRTARLTSNLILISNDIGVLSIPAKHKQEYNTLMLNFYETLE
                     ADEVIKFLLEKCITFFDEYNYKSYKELFKNGN"
     gene            7786..8952
                     /locus_tag="KNP36_002969"
     CDS             7786..8952
                     /locus_tag="KNP36_002969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBF0874823.1"
                     /translation="MATKRANGEGSIGKYKDGWRSRIMIGYNEDGKPIRKEFYGKTQK
                     EVKDKLDAYKKQYYLSSDISDDKITLEHWFYNWLFEYRIKDLKPKSFERYESIYRNYI
                     KDTDLGNVKLKDLRVSHIQKYYNRLLDSNKSIPTIRQINTKLKTCLSEAEKQGLIQRN
                     YCTMVNIPVEKKENKLEILTLEQQKSFIKAIDGHKLEVLFLLALGTGLRLGELLGLKW
                     FDIDFKKSNLTVKRTLQRTYFIDKTGNRELKVLEQEPKTSNSYRTVPIPKDVLNKLKE
                     HKVNQNSDILKAGELYRNDNYVFCNELGAPIDDKRPLRNLKSILNSLDIEPIKFHGLR
                     KTYATRLFENDVPPKTVQVLMGHYDISITLNIYTQVMEDKKIEAVEKLDKIFSL"
     gene            complement(9069..9299)
                     /locus_tag="KNP36_002970"
     CDS             complement(9069..9299)
                     /locus_tag="KNP36_002970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874824.1"
                     /translation="MEANKTLLQSLYKKIILEFSKQTGKSLEESMDYLYTSETYKLIS
                     EGISDMHCKGHIYLAQELMLENGLMYHKGYPR"
     gene            complement(9548..14119)
                     /locus_tag="KNP36_002971"
     CDS             complement(9548..14119)
                     /locus_tag="KNP36_002971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007062489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIR2 family protein"
                     /protein_id="HBF0874825.1"
                     /translation="MTFEEIMEFNKPYNQKNFDELVNAIKDGYVVPYIGAGMSMLFKD
                     IYPSWSTFLNNTSEEYLEDEDKILFEKIEDYEKKAEFLYEELAKVRFSKHLKKVFGAG
                     YLDAKDKDDFIDKCVYLIPIIFGSGLIITTNYDKVLEKNYGLHNKTVLVSHPGHFEAL
                     NNALRNNELVLYKIHGDITEPTTSIVLTKEQYEKAYSNDELRKMLTQVYTSKELLFLG
                     CSLEKDRPLELLQQVSEAGTGHYAIIPVSSEKKKHRRIELENEYYIQTIMYPEGKHEC
                     VRIILERILEIVLPDEYRRLKDRSLKESRLTNLSCRLTEKWFQNQNNIQIKNLGDRYL
                     PELNVELSLENTFNALGKNEEFKQRFDEKTDKVLSSIKKQKINEVEVDVLVIEEIIQQ
                     FYDKANERLDIKLLKKHFEKISAALDDRINNFKNIIINEDCEKSKKREDEIYKLKQTQ
                     KDIYVYIKYLDSKEIKVVNSPYILLHSAGGMGKSHIIAHTIEKRNMDGHKSILFLGQH
                     FKLDKTPIKHMLEILEIECEFEELLEILNEIGEKEQQRVILFIDALNEGQGKELWKYY
                     LNGIVEQIKKYPWIGLILSIRSEYIPSLIDNNNKIKENLVFIEHQGFSSIEHKAMKKY
                     FDYYGIPYSNIPMPNQEFRNPLFLRIMCETFKGEEINLDTISFTDIYKNYLNILNLRI
                     SESCNYSRHANVVTEVLNEMIKYKYGDGLGNNLIPANKSVEIIINIASKYKINNVIID
                     ELIANGIVNKTVNLNDEEYMHVTYEKLEDYLYANLLVKELKEIGVVDFSHKYKYLVEY
                     EDILEVLAIVLSEETGSDIPNEIFEVFKNKETNYNVISAFINALKWRKKSTITEKTLD
                     YINKIVLGKSYYKIDFYNVLILISTKVNHTLNADYIVKYILQNTMADRDAIFIPIFNE
                     VYEEEESSIKRLLGWCFDFEGFDNTSNETIRLSAMMIATFLISSNRDLRDKSTKALVN
                     LLTGKMDIVIDLLKTFEDVDDPYIIERLYAVAFGCVVSEQSEEMIEALAVYVYNKIFD
                     VDYVYPNILLRDYAKNIVDYAKYKIDSSVLKDMNVEPPYKSIFPKVPTDEEIEGYKYD
                     YKASDFKDYYWSQNTILNSMEVEYTRDGQPGWYGDFGRYMFQHYFHKWKGLDYNDLKN
                     IAIKKVFDMGYDVNKHGKFDRTVQNGRLRDSKYERIGKKYQWIALYELAAQAADNYKI
                     EVYTDAYGTKKEIYCKGTFEPDIRNIDPTVMTVINNNNNKRVHNQLFQFSPIPNNEWL
                     GDFSDLPSINDMVNSVYKNQDFLLLNGWYTWKEENDFKNKNYKNPEKDMWVLINSYII
                     KNDQLEPIVNALKGKDFMGRWLTEPNSNYTLYNKEYYWADGYYFFQNSYYCGEEWVQI
                     DEHKNILEKDYKVLLPTYSYTTEREGDIFQEDFSGTWHKPCSTLFYGLKLRYGQGDSI
                     LYNDYGEVVCFESSELLNEEIGFFINKEIFLKYLNEQGYSVFWTMLAEKRVLEEPYMD
                     RKYIQPTISGVYTLNGENRLVGETIESEY"
     gene            complement(14524..15438)
                     /locus_tag="KNP36_002972"
     CDS             complement(14524..15438)
                     /locus_tag="KNP36_002972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003517747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II restriction endonuclease"
                     /protein_id="HBF0874826.1"
                     /translation="MELVKNIHKNKSKDEIFKELLENLKGTIASWDYYVNWNKALENT
                     RKIEVQLNILNYLIGKEDIENETKNLLKEYPEVLSVIPIVIASRDNEFKILDPSDEDM
                     FKYKLFNFKKRKSISDEESELATEFLKKIKFLDLLKQKNIKNLVDYVFGVEVGLDTNA
                     RKNRTGSSMETLVERYVKNMCEKNNWSYLTQATVKKISEKWSIEVPTDKSKRKYDFAI
                     NNNGKIVLVEVNFYNGGGSKLKSVANEFTKLDKYIKDGGFTFCWITDGLGWLESSIPL
                     RDAFDKMDYIFNLDMVDKGSLEYIIKNL"
     gene            complement(15457..16371)
                     /locus_tag="KNP36_002973"
                     /pseudo
     CDS             complement(15457..16371)
                     /locus_tag="KNP36_002973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008909111.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA adenine methylase"
     gene            complement(16799..17148)
                     /gene="ssrA"
                     /locus_tag="KNP36_002974"
     tmRNA           complement(16799..17148)
                     /gene="ssrA"
                     /locus_tag="KNP36_002974"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(17306..17761)
                     /gene="smpB"
                     /locus_tag="KNP36_002975"
     CDS             complement(17306..17761)
                     /gene="smpB"
                     /locus_tag="KNP36_002975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HBF0874827.1"
                     /translation="MAGKKILATNKRARHEYFIEETYECGIELKGTEVKSIRQGKVNL
                     SDGFASVDNSEVFLKQVHISPYEQGNIFNVDSLRVRKLLLHKHEIRKLIGATTIKGYS
                     LIPLSLYLKNGKVKVEIALAKGKKLYDKRQDMAKKDAQRRIEREMTGKY"
BASE COUNT         6109 a         3007 c         1830 g         7130 t
ORIGIN      
        1 aataaatata taaaaattat atatacaaaa aattaagtta tgactagttt ataaataagt
       61 acataataaa attaaagaga gcaatttttt ttgctctctt tcaaaattta tattaaattg
      121 taataataaa aataaaaacg ctagttatct aaggctaata ttttcaacga ttatataaat
      181 atctacataa cagttaaatt acatactctt cttcagttat tgcaacttcc tcagtgacat
      241 atattttttc tattttatta agataatcta ctatacttaa tccaatagcc tttcctagct
      301 taacaggaac tgcatttcct atctgcttgt acacctgact aactgaccct gtaaactccc
      361 actcatcagg aaaactttga attctagcat actctctagt tgtgaatggt ctagtctcat
      421 ctggatgaca cctttcagtt tgcttttgtg caggactaca tgttaaagtt aggcatggtt
      481 catcccaact tattcgcctt gccatacctc tttttccgcc accgctataa taactttttc
      541 ccatataatc tcttgccacc tcatctggca aatctatcca acacccacct ggtggtacca
      601 tatctaacac ttttttcttc ctctcaggat atctagctcc ttccgatttt ggaacatttt
      661 taagtgcatc tcttaacgta gcaacatatt caaacgactt agggaactta aaatccacat
      721 gtgacaaatc ttttcttgtt cctattataa taactctttc cctcttttgt gcaactccat
      781 agttcacagc ctttagtatc tcatatttta cattgtatcc aatctcgcta aatacatcta
      841 tcatagtctt taatgttttt ccaccatcat gagatacaag acctctaaca ttctctgcta
      901 aaaacacctt aggctttaac tcttctagaa ttttagcata tgaataaaac aatgtccctc
      961 ttacatcctc taaccctagc ttcttacccg catagctaaa tgcttggcat ggataaccac
     1021 ctgatagcaa atctatctct atattattat caatataatt ctttattcca ttttccgcta
     1081 ttttaacaat gtcaccctgt ataacattcc agtctggtct atttaatttt aatgtatcac
     1141 aagcatattt atcccattct actaatccaa cctctttaaa accagctttt tcaaggccta
     1201 atgctaatcc tcctgctcct gcaaataatt caacacatgt atatgctctt ttagctagta
     1261 cattacttat atctatatgt ttattatttt tatttctctc tctaggattt aattcatatt
     1321 cactgagttc tttatatgta cagtctctat gctctatata atctttatta ctgctacaaa
     1381 tatttgtaaa tttcagttgc ttttcattta catcttccaa acacataatt tcatcgaatc
     1441 caatatctaa cacttcacat aatttttcta cattactttt tataggtgta aatttttctg
     1501 ataatattgc agataactga ttcttagtta tgcccatatt taatgccagt tgattctgac
     1561 ttcttatatt tttctctttc ataatttttc tcactctatt tttatcaata gttatttttt
     1621 tcatttagtt cacctcttaa taaataatat acccttaaat agttaataaa atacattaac
     1681 tatttaagga tatattatca taattctaat ttttatgtaa gtagttataa aaacttaaaa
     1741 taaaatatct gtaaacaacc taatattacc tcataatttt acacattatg gaatatattg
     1801 tataattaca ttaatacttt ttagggggat tattttatga ctgaattaga aaaacaagaa
     1861 atactagata aagccaaaga tttttttaca aatattttgg ttgctaatca taaaaagaat
     1921 actattaagt taaatttaaa ggcatttaat ataaatcctt ttttagttaa atacttagct
     1981 agtttcttaa caggatcaaa taaacctgaa gatattgcta aagcattgat ttatccaaga
     2041 gttctaggca cttcgattaa tacgtccttc ggaactaatt tacaaaaatt ctgtattacc
     2101 actttagatg gttttgcctc tacaacttct ggcattgata tagagtttat tgattgtatt
     2161 gatggtagaa ggaaattctg tcaaattaaa gctggaccaa acactattaa taaagacgat
     2221 gttaaaacta taattgacca ctttagctca gttaaaagac ttgctagaac aaatggactt
     2281 tcattatctt ataatgactt aattgttggt gttttttatg gaacagaaaa tgagcttaat
     2341 gctcactata aaagaattaa tgaagagtat ccagtagttg ttggtcaaga tttttggtat
     2401 aggcttactg gtgatgaaaa tttttatttt gatttaatag atacaattgc tcaatctgct
     2461 ttagaagagg actgtactgt tttacttaaa aaaacaatat ccaatctagc tgatgaaatt
     2521 tctaaagata aatctttatt caatcaaaag taatataaaa atgattaaat agcataattt
     2581 acatttttag atatttaaaa ataatattca ccaaacaaaa ttattaagta aaatgaaatg
     2641 tatcttataa aagctgagct ataagtaaat ctttgtaaaa acaaatttac ttatagcttt
     2701 tttatgttca aaaaacacaa attatatact atttaatata ttataaactt ttatttgtta
     2761 atactctcta ctaaatttct aacatctctt atataaatta actatttaat aattcaatca
     2821 taaatctagc tcctgcctta aaaccaagct tataaccaag ctctctttca atctctataa
     2881 ctgaattaaa taaatcattt aactctatca atacatccat tttcttttct tctgataaat
     2941 ttttttctag taatttatta actttcttaa tttctttaca tctatcatta taatactcat
     3001 ctttttctag tactttccta tacatgtgtt catttatcca ataatcaaaa tatatttcta
     3061 taatttcatc atacatgtta gtacctcctt gactttcatc tggtacttaa tatatactta
     3121 acttgtgtag attagtgtac attaagtacc taatttataa aggtagttgt tatatttata
     3181 tggcaactac ctttttctaa taaatttttc aatctaaata ctatatattt taaatcttca
     3241 ttgcttacta ttgaggatta tatacttttc ttctaacact ccttaaacaa tagtttatat
     3301 atcacttaat aaattatatt ttttcatacc tcctttacct tcttacattc cttaaaagaa
     3361 aacaaacttc ctatatacca ataaggtcta aagcctgatt ccccatctct atttttagca
     3421 actataattt cacttaaatt agctccaaaa cctttttctc tacgtcttaa ttcttttata
     3481 tcctctattc ccattgtctt acaataatca agagcctctt tctctgtagg tctatgaata
     3541 tatatgactg aattagaatc catatatatc tgttttgaac ttctcattac tctatctcct
     3601 tttggccttt catccttcaa ttcatcattt aattgagcca actgtataat tggaatatta
     3661 aagtctaaag taatcttttt tatttgcctt gataaatcag caaacttagc ttctccaact
     3721 tctttacctt cgtaatccaa aatctgaaga taatcaatta taacaacatc tggtttaata
     3781 ctttttattt ctctcttaat tcctgatatt gtattgactg aatcattaat atagagatta
     3841 ttttcctgat ttaaagtact taaagcattt atgtatttaa ttatttcttc ttcatttaga
     3901 tttctattct tcatttttac aactgatatt ccagttaaag aagctatgtt tctaaacaaa
     3961 atttgtatat cactcatttc cccacttata aaaagtactt ttttaccttg aaataccaca
     4021 tttctcatta tctgtaaggc tagtgctgtt tttcctcttc cacttttggc tgctattgta
     4081 attaattcac cactatatag acctccaata gtttcatcta aaaattttat tcctatatcg
     4141 ataccttctt caatttcatc atttatgtat tcaaaggctc tttctgatat agctgttata
     4201 ctagaatcct tcttaaccaa tttctgatta acttcattaa cgtatttttc taattgatat
     4261 ataagtgtat tatcatctat ttcacctaat ttgaatttat taaatttatc aattatattt
     4321 ctatttttat atttttcaat aactatctca atataatggg atacattacc tatagttgga
     4381 actattgttg atagttttgt caaataactt atacctccaa cataatctat aagccccttt
     4441 ttctttaaat cttctgtaag agttattata tctataggct catccctttt atgtatatct
     4501 ttcactgaat tgaatatatg tttgtgctct tgatgataaa acatatcttc acttattaat
     4561 atctcaatct cttctatttt cctagaatct agtaaaatac tacctaatat agattgttct
     4621 gcttctgtgt tcttaactaa attactcata ttatccataa tataaactcc ctaccacttt
     4681 aattgtgaat catctggact atatgcttct gcatctactt tgacattaat tgatttatct
     4741 tgataattgc cttctaatat cttaataaaa ttatttgggc tcattatcca atcaaaattt
     4801 gccttccaac ctttttcatt gcttccattt aaaaagctag ttttactaac tatatgaata
     4861 atttctaata cagtctcttt atcatattct tttattctag cattaattac tttttttcta
     4921 gcttctgtaa gtttctttac ttttgatagt tctgtacaag taatattgaa tttttctata
     4981 atttcactgt atattttact tttttcatta tttacattct tgttagttgt tagttgcttg
     5041 ttaattgcat gttgattagt ctgttgattt tcttcattag attgatatag ctcccagttt
     5101 tcaatagtta taagcctatt tttgtttgtt gatttatttg ttagaaatcc atatctttca
     5161 aatttcttta aagcagttct tacattctga atacttacat cttttgaaca catatttgct
     5221 atactttcca aagatgttat taactgtcct gatttaactt catattcttt acctccataa
     5281 acccatttat taggcttatg attaactgac agtaataggt ttatgagtat atctctttgt
     5341 ttggaattac aatctttata tagtgggctt tcttttatct ttctatgaag ctttatccaa
     5401 cctagattac tcaaatacta tcacccactt aagtctataa ttttatacca tttgcatttt
     5461 caataaacca attatctagt ttatttttta ttatatacac tctattatct atccatatac
     5521 aaggaaatcc tttattttta gaatgacata actgtctaaa ttttgattcc cctatgggat
     5581 aaattttaga agcttcttta caagtgataa gttgagcttt atctcttcta tatgtctgta
     5641 tctccttgta ccctttttcc ttttcttgtg cttcttgttc ttgcttgaca agtatattca
     5701 atgtagcttg tagtgtttta agaacttcta gattatttgt atctgccata catcattcct
     5761 ccttatcaaa aaataattct tctacacttg tatctagttc ttgagccaat tttaacatca
     5821 acatattact tggatttttt gatttacctc tttctaaaga agataaataa tatcttgaga
     5881 tgccaacttt ttcagctaat tcatattgct ttataccttt ttcaattctt tttaatttga
     5941 gtttcattga tttcctcctt tctttcatac ccattttgtg tatcctcatt tctataaaat
     6001 attctaacac ccatttggtg tattgtcaat atatttaagt gtatcaatag acccatttag
     6061 tgttataatg tatttgaggt gaaattatga tagataatac aattggaaaa aagattaaac
     6121 aatatagaaa atctataaat atgtcaaggg atgagttagc taataagatt ggttgctcag
     6181 tttatgctgt agctaaatat gagcaaggcc aaagaaagcc tagtttagat atgataaaaa
     6241 aaatatctac tgcattatca attcctataa ataggcttat tattgatgaa agtgatttag
     6301 atacttcaac aaataattat actaatttaa aagaattgga tttagttgta aaaacatttg
     6361 ataattactc agcaaaactc atcggaaata atataagcaa atttagaaat ataaataata
     6421 tatctctcaa agaactctca gaaaaaataa attgttctga gaatgaaatt ataaattatg
     6481 agaatggaac aaaaatgcct agaattgaaa tattaaaaaa aatagcactt gctacttata
     6541 ctaagattga agacttattt ggatttccat tagaagagat aaaaatagat aaccaaacaa
     6601 tcctctatag aaatccccag actggatata ttatagataa ctttcttatc gattttataa
     6661 ataaagatat taacatagat aatactccag tttcttatta tatagataag tcagaatttg
     6721 atttagtaat tcatatatta aaaaattatg gttatgatgt aaaaacagat tataagacaa
     6781 agtttgaaat tgcagataat gcagatacaa taaaaccaat tagcttaagc ttctctgact
     6841 tcaaagactt ctccaaaaat ctaaattggg tgataaatgg tcttgttgaa aattttatac
     6901 aagaaaactc taatggtctt attgaagatg aggatgaaga atattagtat tgcacatttt
     6961 caaaatatga gtttacctat taacttttat acattcatag ttaataaata aaaattagat
     7021 atgatatgaa aggagctaaa atcatgaata aatcatatat accaaaatac acacataaat
     7081 tccctactaa tctacctcat ggagataaaa aatatacttt aacatacatt agaagaatga
     7141 taagtgaatt tgtatatgat atgggtaacc tagaaaataa cccctttaca ttcccagaag
     7201 tacaaacatt acttgatggt ataaccgtag gtggacataa attaagtgac caaaatcaaa
     7261 tactaaatat aaaatcatca tgggattatg taataaaatt aagtaacaaa gaaaacttat
     7321 ctttaaataa agatacaatt tgctctatac ataaaatagt tgcaaaagat gaagctctaa
     7381 tagttggaga ttttagaaat ggtaacatag gtatagctgg tactactcaa tatgaatgca
     7441 tagaagccac tctattaaat gatttatttg taagcgacat aaatatcata aataaaataa
     7501 ctaacccctt agaaaaggct ataataataa atttatggtt gtcctattgc caattcttct
     7561 atgatggcaa caaaagaact gctagactta cctcaaacct aatacttata agtaatgata
     7621 taggagttct atcaatacca gctaaacata aacaagaata caacacatta atgctaaact
     7681 tttatgaaac actagaagct gatgaagtta taaaattctt attagagaaa tgtattacat
     7741 tctttgatga atataactat aaatcatata aggagctgtt taaaaatggc aactaaaaga
     7801 gctaatggag aaggctctat cggaaaatat aaagatggtt ggcgttcccg tataatgatt
     7861 ggctataatg aagatggtaa accaataaga aaagaatttt atggtaagac tcaaaaggaa
     7921 gttaaagata aacttgatgc ttataaaaaa caatattatt taagctctga tatttcagat
     7981 gataaaataa ctttagagca ttggttttac aattggttat ttgaatatag aataaaagat
     8041 ttaaaaccta aatcatttga aagatatgaa agcatctatc gtaattatat taaagatact
     8101 gatttaggca atgttaaatt aaaggactta agagtatctc acatacaaaa atattacaat
     8161 agattgcttg attccaataa aagtatacct actataaggc aaataaacac taaactgaaa
     8221 acctgcttat cagaagctga aaaacaaggt cttatacaac gtaattattg tactatggta
     8281 aatataccag ttgagaaaaa ggagaataag cttgaaatat tgactcttga acaacaaaag
     8341 agttttataa aagctataga tggacataaa ttagaggtat tatttttact tgctcttggt
     8401 actggactta gattaggaga attattagga cttaaatggt ttgatattga ttttaaaaag
     8461 tctaatttaa cagttaaaag aacccttcaa agaacatatt ttatagataa aaccggaaat
     8521 agagagctta aagtattaga gcaagagcca aagacatcaa attcttacag aactgtacct
     8581 attccaaaag atgttttaaa taaattgaaa gagcataaag taaatcaaaa ttcggatata
     8641 ttaaaggctg gagaattata tagaaatgat aattatgtat tttgcaatga attaggtgcc
     8701 cctattgatg ataaaagacc tttaaggaat ctaaaatcta tattaaacag cttagatata
     8761 gagcctataa aatttcatgg tcttaggaaa acttatgcga ctagactttt tgagaatgat
     8821 gtccctccta aaactgtaca agttttaatg ggtcattatg atatatcaat aactttaaat
     8881 atatatactc aagttatgga agataagaaa attgaagctg tagaaaagtt ggataaaata
     8941 ttttcattgt aaaaatcaaa tatataaaaa tactctgatt tcatatagtt aattacaaaa
     9001 ccaaaataag gatacaaatt aattttatat tatcttgtat ccttattctt gtctagtttt
     9061 ttaaatattt atcttggata gcctttatga tacattaatc cattttctaa cattagttct
     9121 tgggctaaat atatatgacc cttacagtgc atatctgata taccctcact tataagttta
     9181 tatgtttcag aagtatataa ataatccata ctttcttcca agctcttacc tgtttgttta
     9241 gaaaattcta atatgatttt tttatatagc gattgtaaca atgtcttatt agcttccata
     9301 aaagctatac ctcctctttc aaatatttgt ttatcctatt ttgactaact atatatttat
     9361 tagttattta attagccata ataattcggc tataagatat ttataatcta atctcaatta
     9421 tataaatctt tttgccaata tttaataatc aaaatattgc acttaattaa ctatcttata
     9481 agtattgata ataaaatctg tcttcttaaa tatacttaaa taaaacttct ataattatat
     9541 caaagtatta atattcactc tctattgtct ctcctacaag tctattttct ccatttaggg
     9601 tatatactcc tgatatagtt ggttgtatgt attttctatc catatatggt tcttctaaaa
     9661 ctcttttttc tgctagcatc gtccaaaata cactatatcc ttgttcatta agatatttta
     9721 agaaaatttc cttattaata aagaatccta tctcttcatt aagtaattca ctactttcaa
     9781 aacaaacaac ttcaccataa tcattatata gaatcgaatc tccctgacca tatctcaatt
     9841 tcaacccata aaatagagta ctacaaggtt tatgccatgt gccagaaaag tcttcttgaa
     9901 atatgtcacc ttctcgttca gtagtataac tataagttgg caataatact ttataatcct
     9961 tttctaagat attcttatgt tcatctattt gtacccactc ttctccacaa taatatgaat
    10021 tttgaaaaaa gtaatatcca tctgcccaat aatattcctt attataaaga gtataattac
    10081 tattaggttc agtaagccat ctacccataa agtcttttcc ctttagagca ttcactattg
    10141 gttctagttg gtcattttta attatatagc tattgattaa tacccacatg tctttttcag
    10201 gatttttata gttcttattt ttaaaatcat tttcctcctt ccaagtatac catccattaa
    10261 gtaataaaaa gtcttgattt ttgtaaacac tatttaccat atcatttatg cttggtaaat
    10321 cactaaaatc tcctaaccac tcattattag gtattggaga aaattgaaat aattgattat
    10381 gtactctttt attgttatta ttatttatta ctgtcatgac agttggatca atattcctaa
    10441 tatctggctc aaatgtaccc ttacaataaa tttctttttt agtaccataa gcatctgtat
    10501 acacttctat cttataatta tcagcagctt gcgctgcaag ttcatataat gcaatccatt
    10561 gatatttctt tcctattctt tcatatttac tatctcttaa tctaccattt tgtactgttc
    10621 tatcaaattt accatgttta tttacatcat atcccatatc aaaaactttc ttaatagcta
    10681 tattctttaa atcgttatag tctagacctt tccatttatg gaaatagtgt tggaacatat
    10741 atcttccaaa atctccatac catcctggtt gtccatctct agtatattct acttccatag
    10801 aatttaagat agtgttttga ctccaataat aatctttaaa atctgatgcc ttatagtcat
    10861 acttatatcc ctcaatttct tcatcagttg gtactttagg aaaaattgat ttatatggtg
    10921 gttcaacatt catatctttt aatactgaac tatcaatttt atattttgca taatctacaa
    10981 tattttttgc ataatctctt aataaaatat tgggataaac ataatctaca tcaaatattt
    11041 tattataaac ataaactgcc aatgcctcta tcatctcttc tgattgctct gatacaacac
    11101 atccaaatgc aactgcatat aatcgttcaa taatatatgg gtcatctaca tcttcaaatg
    11161 ttttaagtaa atctattaca atatccattt tccctgttaa tagatttaca agagcttttg
    11221 tacttttatc tcttaagtct ctatttgaag aaattaaaaa cgttgcaatc atcatagctg
    11281 acaatctaat tgtttcattt gaagtattat caaaaccttc aaaatcaaag caccatccta
    11341 ataatcgctt aatagaagac tcttcttctt cataaacttc attaaatata ggtataaaga
    11401 tagcatctct atctgccata gtattttgta aaatatattt tactatataa tctgcattta
    11461 atgtatgatt aacctttgta gaaattaaga taagtacatt ataaaaatct attttataat
    11521 aagatttacc taaaactatt ttattaatat aatctagtgt tttttcagta attgtagatt
    11581 tcttacgcca ttttagtgca ttgataaatg cactaataac attataattt gtttctttat
    11641 ttttaaaaac ttcaaaaatt tcattaggta tatctgagcc tgtctcttca gataaaacaa
    11701 ttgccaatac ttctaatata tcctcatatt ctactaaata tttatactta tgtgaaaaat
    11761 ctactacccc aatttctttt aactctttaa ccaacaaatt tgcatataaa taatcttcta
    11821 acttctcata tgtcacatgc atatattctt catcatttaa attgactgtt ttattaacta
    11881 ttccatttgc tatgagttca tctattatca cattgttaat cttatactta cttgcaatat
    11941 ttattataat ctctacactc ttgtttgcgg gtattaaatt attcccaaga ccatctccat
    12001 atttatattt aatcatttca ttaagtactt ctgtaactac attggcatgt ctactataat
    12061 tgcatgattc agatattcta agattaagta tattcaaata atttttataa atatctgtaa
    12121 aactaatagt atctaagtta atctcttctc ctttaaaagt ttcacacata attctcaaaa
    12181 aaagagggtt tctaaattct tgatttggca ttggaatatt agaataaggt attccataat
    12241 aatcaaaata ctttttcata gctttatgtt ctatactaga aaatccttga tgctctataa
    12301 aaaccaaatt ctcttttatc ttgttattat tatctattaa agatggtata tattcacttc
    12361 ttattgataa tattagtcca atccatggat atttctttat ctgttctaca ataccattta
    12421 aataatattt ccaaagttct tttccttgac cttcattcaa tgcatctata aataatatca
    12481 cacgctgttg ctctttttct cctatttcat taagtatttc taataattct tcaaactcac
    12541 actcaatttc taatatttct aacatatgtt taattggtgt tttatccaac ttaaaatgtt
    12601 gccctaaaaa taatatagac ttatgcccat ccatatttct tttctcaata gtatgtgcaa
    12661 ttatatgaga tttccccata ccacctgcac tatgtaataa aatataaggg ctattaacta
    12721 cttttatttc cttagaatcc aaatatttta tatatacata gatatctttt tgagtctgct
    12781 tcaatttgta tatttcatct tctctttttt tacttttttc acagtcttca tttataatta
    12841 tatttttaaa attatttatt ctatcatcaa gtgctgcact tattttttca aagtgctttt
    12901 ttaacaactt gatatctaat ctttcattag ctttgtcata aaattgttgt attatttctt
    12961 ctataactag tacatctact tccacttcat ttattttctg tttctttata cttgatagaa
    13021 ctttatctgt tttttcatca aaacgttgtt taaattcttc attttttcct aatgcattaa
    13081 acgtattttc taaactcaat tctacattca attctggtaa atatctatct ccaaggtttt
    13141 ttatctgtat attattctga ttttgaaacc atttctctgt taatctacaa gataaattag
    13201 ttaacctact ttcctttaaa gacctatcct ttaatcttct atattcatct ggcaaaacta
    13261 tttccaaaat tcgttcaagt attattctta cacactcatg cttaccttca ggatacataa
    13321 tggtttgtat ataatactca ttttctaact ctattcgtct atgtttcttt ttctcactac
    13381 taactggaat aatagcataa tgacccgttc ctgcctctga tacttgctgt aataattcca
    13441 acggtctatc cttttccaaa ctacatccaa gaaataacaa ctctttactt gtatatactt
    13501 gtgtaagcat ctttctcaat tcatcattac tatatgcttt ttcatattgt tcttttgtta
    13561 acacaataga tgttgtaggc tctgtaatat ccccatgaat tttatacaat actaattcat
    13621 tatttctaag tgcattattt aatgcttcaa agtgacctgg atgtgacact aaaactgttt
    13681 tattgtgtaa tccataattt ttttctagta ctttatcata attagtagtt ataattaatc
    13741 ctgagccaaa aattatagga attaaataga cacatttatc aataaaatcg tctttatctt
    13801 ttgcatccag ataacctgcc ccaaaaactt tttttaaatg tttagaaaat ctaactttcg
    13861 ccaattcttc atataaaaat tctgcttttt tctcataatc ctctattttt tcaaataaaa
    13921 ttttatcctc atcttctaaa tattcttcac ttgtgttatt taaaaatgta ctccatgaag
    13981 gatatatgtc tttaaataac atagacatgc ctgctccaat atatgggact acataaccat
    14041 ctttaattgc atttaccagt tcatcaaaat ttttttgatt gtaaggctta ttaaattcca
    14101 taatttcttc aaatgtcatt attccctcct aaactatctc ttaataattt caaccataat
    14161 tcctatttta taattttatt atatcattcc attccatttt tttactacaa ttctatgtta
    14221 tagaatgaat tcacttactt acatttgtta ataatataaa actttctttt aagataatta
    14281 aaatttatac ttttaaatta tggataaaaa tggaatgtta taacttttaa tgtattacta
    14341 atattaacaa ttttaaaaaa taatactatt cttattttat gctataatta tattttgcat
    14401 aaatattatt gatattttat aaatataatt atacttatat ctcatactca aatattttat
    14461 ataatatata agtctaaatt aacttgcaat ataaaagcgc ctcttaatat aggcgctata
    14521 atgttataaa tttttaatta tatattccaa tgaaccttta tcaaccatat ctaaattaaa
    14581 tatataatcc atcttatcaa atgcatctct taatggaata cttgattcaa gccatcctaa
    14641 cccatctgta atccaacaaa atgtaaaacc tccatctttt atatacttat ctaacttagt
    14701 aaactcattt gcaacagatt ttaacttaga acctccacca ttataaaaat taacttctac
    14761 taaaacaatt tttccattat tatttatagc aaagtcatac tttcttttac tcttatctgt
    14821 tggaacttct atagaccatt tctcacttat ttttttcact gtagcttgtg ttaaataact
    14881 ccaattattc ttttcacaca tattctttac atatctttct acaagagttt ccatactact
    14941 tccagttcta ttttttctag cattcgtatc aagcccaacc tctactccaa acacataatc
    15001 tactaaattt tttatatttt tttgttttaa taaatctaaa aactttattt ttttaagaaa
    15061 ttctgtagct aattcgcttt cttcatcact tatactcttt ctcttcttaa aattaaacag
    15121 tttatattta aacatatcct catctgatgg atctagtatt ttgaattcat tatctctact
    15181 cgctattact attggtatca cactaagaac ttctggatac tcttttaata aatttttagt
    15241 ttcgttttct atatcttctt ttcctataag atagtttaag atatttaact gaacctctat
    15301 ctttctagta ttttccaaag ctttattcca gttaacataa taatcccagc tagctatagt
    15361 accttttaaa ttttcaagta attccttaaa tatttcatcc ttactcttat ttttatgaat
    15421 attcttaacc aattccattt gattccccac ctcttcataa ttagtaatta gcaattcagt
    15481 tataaaacct cttccattcc ccttagaatt tatgaatctt ttagcatgta ctctttttat
    15541 attaaaatct gaatacaaat catcaaagaa agtatcttct tcatctaaaa cttttggatc
    15601 agaattactt aacatcaatt ttgtatctat tttatctaga actttataaa atttacttaa
    15661 ctcaatttga ctatcatcat taaaattacc tttgttatag gaattaaatc ctcctatagt
    15721 tactggtcta tatggtggat ctagatacac aaaacaattt ttatctatta tattttctag
    15781 atttaaataa ttcttattta atatttttac ttttagctct cctcgagaat ctcttttatt
    15841 taaaagcatg gataattttt caagttcatt tttatcaaaa aaactaggat ttttatatct
    15901 tccaaaaggt acattaaatt cacctcgaga attttctcta tataatccat taaaacatgt
    15961 tttatttaaa aatataaaat atgaagcttg ctttatacaa tcttcatttt ctatattttt
    16021 ttcatttgta agtatattaa atctatctct aatatcatag tacatctttt ctctatctga
    16081 agaaccttct tcgtaagata tgtattgttc ttttaaatta gttagttctg ttattaactc
    16141 ttccaaatca tctctgactt taatatataa attaattaac ttactattta tatcattaat
    16201 tacatacttg ttgaaaatgt cctcttctaa caaatataga aatagtgcac ctgcacctac
    16261 aaaaggttct atataagtca tggaactaaa atcacaacct gtaggcattt gttttcttag
    16321 aatatcaagt agctgtgttt tacctccagc ccattttaaa attggtttca tgcaacacct
    16381 ctctcagtta tattgttata taattatata aaataagatt ctaaaataca agtactcatc
    16441 agaacactat atttatatca aatctttcca aaatctaagt attattttat cctaacactt
    16501 ttcaaaacct ctaaataata tacaatattc tctaatattt acttactaaa aatttaaatc
    16561 tatctttaag tataacctaa aacagattat aagttacgta gtttttaata taaaatatac
    16621 ttctacaagt aaagctttaa atatcaatta cttatttcat aattaatgac tatgtaccct
    16681 caaaaaaacc tcattttcta tggttggggt acggttggtg gatttcatca ccaaaataaa
    16741 aaatactagt caataaagac tagtatttcc aagtatttca tcattctttt ttcaaaattg
    16801 gtggagacga ggggagtcga acccctgtcc gcaaatcttt tccttgctgc atctacatgc
    16861 ttagccaact tcactaatat ctcacctcac atagcgccaa gtggcaggct ctatgcttag
    16921 ccagtcccaa ttaatctact tcaggtcgag acacccctaa agtagttccc tgcataatga
    16981 cgtccagtct tagtcggcag gaggactaag agggacgagc agcaactagg ctgctatcgc
    17041 gaaattatcg tctgcgttta ttttaaagtt ccccagtttt tacgtgaccc agagtaacac
    17101 gacatgcagc ctcaagttcc aaacccacgt cgaaaccttt acgccccctt gagtagttta
    17161 tagtccagta gacttttcgc aaactttatc accattttta ttaaattttt aatgtatata
    17221 taatataata cttttaagaa taaaaatcaa tgttatgttc tagataataa agaattttat
    17281 tctaaaaaat acagttttat ctagtttaat acttacctgt catttctctt tctatacgtc
    17341 tttgtgcatc tttcttagcc atatcttgac gtttatcata tagtttttta ccttttgcta
    17401 aggcaatctc tactttaact ttaccgtttt ttagatacaa actaagtggt ataagtgaat
    17461 acccctttat agtagttgct ccaataagct ttcttatttc atgcttatga agtaatagtt
    17521 ttctaactct taaagaatca acattgaata tatttccttg ctcatatgga cttatatgaa
    17581 cttgttttaa aaatacttcg ctattatcta cagatgcaaa tccatcactt aggttaactt
    17641 tgccttgtct tattgatttt acttctgttc cttttaattc aattccacat tcataagttt
    17701 cttctataaa atattcatgt cttgctcttt tgtttgttgc taatattttt ttaccagcca
    17761 tataaatctc accttctttg ctagaaattt attccataaa tattagaaat ttactaaata
    17821 tttaatgttg ccaaattatt tgactaactt gtatgataac atatttaggc attttagtca
    17881 atatttcact gatatattaa gttagttagg ctatatataa ttaagtaata taaatgtatg
    17941 aaaatagcta aaaaactact tcgaatatac ttaatactaa actaactcta accagtaata
    18001 ctaatttata aatttcaaaa caaaaatatt acatattata aatcttctat cttctatctt
    18061 ctatcttcta tcttct
//
LOCUS       DAEHWM010000091        18069 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.092, whole genome shotgun sequence.
ACCESSION   DAEHWM010000091 DAEHWM010000000
VERSION     DAEHWM010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 18069)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18069)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18069
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.092"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            478..1338
                     /locus_tag="KNP36_002976"
     CDS             478..1338
                     /locus_tag="KNP36_002976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0874828.1"
                     /translation="MKIIQILNNNVALVKRGKNEIIVFVKGIGFKKRVGQVINENEIE
                     RTYILDSYDMLEHFSYLLQNSDSNNIVLINEIIEYGEKTLNIKASDYLSLTLLDHLEF
                     LLKRCKKNQFIKSPLVWNVKRFYPKHFEIGMHALKLIGDSKGINLPDDEAVSIALHFV
                     NMEVNKESHDSTIVELRTLADIVSIIKYHFNVELDETSTNYMRFTTHLQYFIQRIMSE
                     EASIDEDNSIDLYKQVSQLYPKSFGSVQKIRKYIKSQFNVDISISEETYLMLHINRVT
                     QRLEAKSDEI"
     gene            1328..3199
                     /locus_tag="KNP36_002977"
     CDS             1328..3199
                     /locus_tag="KNP36_002977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0874829.1"
                     /translation="MKYKDLNENIIKLIGGKENIKSVAHCVTRLRFTLNDRSIAQTEE
                     IKKLKGVIDVVSNDVAYQIIIGTHVVDVYNEFMSMIGLSSSESSIKSERKKGIRGIKG
                     IFNSIFVVVSETMTSVIEVLLAAGILASILALLNMSGILQSDSPTYQILDTLRSATFH
                     FLPVLIAIASAKRLNVNPYIAVVLAVTLLSSSIDGVEGLSLFGINLQSTTYANSFIPI
                     LLGVWAMGIIIEGLKKILPKALHYFLVPVLSLIITLSVTLTVFGPIGMWIGDGLNYAC
                     MFLIDTLGNWSVVALYAALQPLLIVFGAANFTMPISLNSVTTLGYDPIFMGAATISDI
                     AVCGAMFGYFLKTRNKEQKQLFGTVSFSALMGVTEPSVFGVFMKYRRPFVAVMIGGGI
                     GGLIAGLAQVKTYGMVWGLAALPTYLVGGEVSNFTFMIISVVVSFVAATAASYLLGIP
                     SDEKEEVKGDNEKELELIINENNSRTISIGNVAKGQVIALGEVNDKAFSSGALGKGVG
                     VIPSESKSTVISPVDGTITIVFPTKHAYGIVTDEGLEILIHIGIDTVNLDGKFFESLV
                     TQNQRVKKGDALAVFESDKIIEEGFDSTIITVVTNTSDYLDVISSNDESEELLTVIV"
     gene            3219..4673
                     /locus_tag="KNP36_002978"
     CDS             3219..4673
                     /locus_tag="KNP36_002978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HBF0874830.1"
                     /translation="MNIKDTFFWGGSIAAHQCEGSWDSDNKGPAIMDFVTKGSYEMPR
                     VITDKIEEKLDYPSHNGIDFYNRYKEDIALFKEMGFSALRISIDWSRIFPNGDDENPN
                     ELGIKYYEGLIDTLIENNIEPIVTLYHFELPMNLVHKYGSWNNRKLIDLYLKYSETVI
                     RRFDDKVKYWVTFNEMNHIDPQTEHSDIFTYMIAGIKYSEIENKVQTLANVGYNMTLA
                     GVKVAKLAREINPNNKVGCVFGLNPIYPYNCNPSNVLNAFLDNDRDYYQIDAMCNGKF
                     PQYKLKEYEKNNITIEVTDEDKKAFKEGKLDFIGLNYYFSSVSTPKENLSGDKSLFGG
                     IQNPYLEQSKWGWAIDPIGLRFTLNYIYRKYQLPILITENGLGAYDKIEEDGTINDDY
                     RIEYLGKHLSQMKSAIEEDNVECFGYLMWGPIDLVSATTGQMSKRYGFIYVDLDDEGK
                     GSFKRYKKKSFDWYKEVIKSNGEVLDFSTDIVVG"
     gene            5698..6906
                     /locus_tag="KNP36_002979"
     CDS             5698..6906
                     /locus_tag="KNP36_002979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874831.1"
                     /translation="MENFWNPLTCFTVCVMIYAFSEFLSKKTKGAISTLLFVCIIFLL
                     GFWTNILPKDITGASGILAAMSNFGIALLITNLGTLINLEDLCHEWKTVVIALVGIVG
                     IGVGCLTVGSMLFGREYALIAAPPIAGSTVAGIIVTTVAEAANRPELAAFVILVLSFQ
                     KFFGIPITTYCINKELKFKRDNGDFLKDESKSNFKLPSMRIFKEDLGKKSSTLVYLAK
                     LSFVAMIGNFVGLATLIPGFTPANYYLNPNIACLLVGLIFTRIGFLEKGILDKSQSNG
                     IIMFGCMLMLPGGLAKVTPTALFGMIVPTIGILVVGSVFIILFTAIVGKLLGYSPRMS
                     AAIGVTCMLAYPATQIISNEGIDAMEGTEEEKQRATDYLLPKMIIGGFVTVTIASVAF
                     ASIIGPIIFG"
     gene            6937..8316
                     /locus_tag="KNP36_002980"
     CDS             6937..8316
                     /locus_tag="KNP36_002980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0874832.1"
                     /translation="MIGSISINEIDKKRFKLDDLSKKIWENPEKAFKEFKACENTANF
                     LRSEGFDVEVGVGGLATAIRASFGSGKPVIGFMGEFDALPGLNQKVSTKQEAFELGAY
                     GHGCGHNLLCTAHVGAVVGLKREMIENNLSGTIVFYACPGEEQLTGKGFMARGGAFEG
                     LDLAINFHPNKISEATIGTSTAVNSVKFHFKGKTAHAGSDPQNGRSALDAVELTNVGA
                     NYLREHVTSDVRIHYTITDGGVAPNIVPDKASVWYYTRALSREAVESTYERLVKVAKG
                     AAMMTETEVEVEFLGGCYNTLNNHVLANLVSECMNEIKQEPWTREELDFAAELDRQSP
                     QQYKAMISKYNLPEGTHLYYGGGNVTNFNSYGSTDIGDVMHIVPTAYFFTGCTNLGAP
                     GHSWQFTSCAGSSIGEKGMIYASKIMAMFGAKILNNPEIAKKAKEEFDKSMNGKTYKC
                     PIPDDIPTP"
     gene            8422..9612
                     /locus_tag="KNP36_002981"
     CDS             8422..9612
                     /locus_tag="KNP36_002981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0874833.1"
                     /translation="MKNFFKEAQSIEGEIIRWRRYLHENPEIGCNLPKTVTFVTSTLE
                     KMGYSPKLTSNNGIVAVLDSENGGKTLLLRADMDALPIREETDLPFKSKNKDASHSCG
                     HDNHTAMLLGAAKILMDNKHLLKGRVKFVFEPDEETTRGAKSMIDDGILENPQVDAAM
                     AFHSMVGKFLNTGQVAYSRGPAMASADIFEITVEGKATHGASPEFGVDPINIMSHIQI
                     ALNTILSREKPQKEPVVLTIGMFNAGNVPNAIPNKASMSGTLRTFDQFVREKLKNRII
                     EISTGIAKSFGGNAKVEFKMGTPAVINDLDVGDEIVSYVKEVIGNENVIDFPSAMGSE
                     DFSEVLLRVPGVFLWIGMGSISQGYNFGMHNPKAIFNEEGLVYGSALFAHCAVKWLEN
                     NFSR"
     gene            complement(9740..11068)
                     /locus_tag="KNP36_002982"
     CDS             complement(9740..11068)
                     /locus_tag="KNP36_002982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874834.1"
                     /translation="MMKIAVITTEFLKEFVDNSIKKLNINAEIEIYIYRDFSHVGDLY
                     LEIEDRFDGFAVSGPIPKKAITKKAGTIKKPLVDFGTDLQSYYDMFLKLIFKYNTLDF
                     SRAYFDLTDWADNPKDISYYLSNGTFGDLMDSIDENASKMSLSDIAKLEKKIAKKHIN
                     LWNEGKIDFSTTRFSSIVPMLQNAGVNFHFIYPDIDLLKNTFNNLIKDIHLHRMKGNQ
                     PSVIYITVKDTNYDDSTLDQVYKILNSIKKDKLTDFIIEKNSNSFKIFTKCETIKSLT
                     KNFTACYIKESIENSTNIKVCIGYGIGNDIKQAMSSAISANKESKINPLNYSFLVNEN
                     YETIGPLLCDKLLTVSNKVTPHINTIAKSSKLSTLTIQKIISVTEILQRDEVTPKELS
                     SCLNVTVRTANRFLSSLLKSGNATILYEKQNSTKGRPERVYKLFISENKY"
     gene            complement(11686..12900)
                     /locus_tag="KNP36_002983"
     CDS             complement(11686..12900)
                     /locus_tag="KNP36_002983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HBF0874835.1"
                     /translation="MRNCIIAQSGGPTAVINASAVGIYEKNLETKYFDKVYFGINGIE
                     GILNKNIIDSDSLNKDNVLNLKQTPSSGLGSCRYKLADYKINSYDYDRVINILDEYKI
                     DTLFYIGGNDSMDTVMKFSQYCKNTTCKIKFIGIPKTIDNDLLGTDNCPGFGSAAKLI
                     STLIMETYLDFSIYKNNGIFIVETMGRDTGWLAASSSLARLNDTPLVDLIYLPEIDFY
                     EDKFIEDVRKIFKEKNKAYIVASEGIRDKYGNFICEQKTSAHDKFGHSQLGGVSNYLK
                     NLIVSSSITTRVKTLELGVIQRCAMHLASDTDLKQAAEVGAYGIELSKKGYTGVMAII
                     NRTCNNPYKYEVSHTDISKIANKTKYFPKEWINEECNYITDEALNYLYPLIQGKPDIK
                     YKNGLPYFSIIY"
     gene            13326..14042
                     /locus_tag="KNP36_002984"
     CDS             13326..14042
                     /locus_tag="KNP36_002984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentose-5-phosphate 3-epimerase"
                     /protein_id="HBF0874836.1"
                     /translation="MKHIKIAAGLAHVNYGHISAVVKEAMDAGVDYVHSDAADMHDLK
                     NMQLMGGHQIIEAIRPVTDKPIECHIYTRDCDRLFIEKIAAAGCNLLIIPAEHFLGAP
                     LAYIINYCREFGMKVGLTIGCYTPLCFVDEAIYDIDRLQIVVHGVDETDGKDNWGWRK
                     SAVDLVKRARKMIDEKNPKCELAIDGGLRADNMEPLIECNPDVVILSSAIFKDKDGIT
                     AGVKNCRKAIDEAATKFGLE"
     gene            14177..14803
                     /locus_tag="KNP36_002985"
     CDS             14177..14803
                     /locus_tag="KNP36_002985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBF0874837.1"
                     /translation="MKKEMIKDYLLITISAFLMALAVNFFFAEHTLAPGGITGLSVVL
                     STFLSMPVENISLGISMPLLVMGLLFLGKGFGIKTLYITLMGPLFLKVIPQTHITDNL
                     LVAGVIGGLLVGTAIGIAIIRGCSTGGTDLVAMLINKVIKFLKLPVILFMLDGFIIVA
                     SGIISKNFMISIYSLISLLLIIKTIGFVTTKFGKNTEEINNINNACAQ"
     gene            complement(15003..16547)
                     /locus_tag="KNP36_002986"
     CDS             complement(15003..16547)
                     /locus_tag="KNP36_002986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0874838.1"
                     /translation="MNKRLLDIAELLLNSSDYITVDTIAEELKVSNKTIRNDLVILDE
                     WLLEFNLSLDKKTGSGVIILGNEDIKLKVIRDINDKSNCIYAYSPEDRKRYILSKLFI
                     KNSKFRIRDICNELHVSRATVHKDLVVIQNFLQNFKVTLVRKTNNGVYLEGKEKDIRK
                     AIFELATVNKSYTELKEILFSKSNECKDTPSTKIFKELFNYDFEKLSQITLHTLQVEK
                     SNLSDEYYINFLIHIAICIKRISIKRYINLSEGFFRELLEHEYFEKSKILCANLSEAF
                     DVEFIDEEVCYILLHIEGLLKSIKKTTTLEPLKNEEITEYNLSEAIAVHWGSILNLNL
                     KDDLILIKSLANHLKSVLHRINYGFTITNPILNDIKRTFPYTYKAAKESNTVIKQLMN
                     YEVNDDEIGYLALYLISAIDRSKSPLNTILICHCSDGVSNLLVQKLSFEFNQINIVKS
                     IPLSSISFTNFDDVDLILTTAPVDFEHNAELININALLSKNDISRLSTIIKKLYSEKN
                     KILSYK"
     gene            complement(16573..17214)
                     /locus_tag="KNP36_002987"
     CDS             complement(16573..17214)
                     /locus_tag="KNP36_002987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldolase"
                     /protein_id="HBF0874839.1"
                     /translation="MKYLIDSANLDEIQKCLKYGFKGITANPSMYLKEKVNFHEFIET
                     CANLNPEILTAEVIGNNLYELINSCDKILNINKNTIIKINFSEVGLELINILNSKGVK
                     TACTLIFNVNQASLAINAGADYLFPFIGRNDENGNDGIKNLTEICNLISINGYNTKVV
                     AASIKNVFHLTQASLCGCDYAAVTYDLFKKASFNQLTIDGANTFERDWSKVNK"
     gene            17484..17675
                     /locus_tag="KNP36_002988"
                     /pseudo
     CDS             17484..17675
                     /locus_tag="KNP36_002988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422425.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
BASE COUNT         6683 a         2134 c         3001 g         6251 t
ORIGIN      
        1 aactaaattt gaagctttac ctattaatat atcttaatag tgattaaata aaactaaact
       61 taagacttta tatgttaata tatcttaaga atttatttgt taaaatacag ttcattatat
      121 ttaaaagcat tactatgata attcataata gtaaaataga taatggttca gacaatatta
      181 taaatactag tgacggtaaa atagtatcaa tttagtatat aaaccttgtc agataatcgc
      241 ataacagagc ttgtagttat agaataaaaa aatatctagg aaaccgttga cagatttata
      301 tggatagtat aacatataga atatgaaatt aaacaaaaaa gaattttaat tatggcgacg
      361 tagtcataat tttgagtatg ttactgatta gcaggcagaa ctcaagtata tatgtgaaaa
      421 atagagggat actctataca tatatgcttg agttcttttt attgaaggga ggaatatatg
      481 aaaataattc agattttaaa taataatgta gccttagtaa aaagaggtaa aaatgaaatt
      541 attgtatttg ttaaaggaat tggctttaaa aaaagagtgg gacaagtaat aaatgaaaat
      601 gaaatagaga gaacatatat actagattca tacgatatgc tagaacactt tagttatcta
      661 ctacaaaact cagactccaa taatatagtt cttattaatg aaataattga atatggtgag
      721 aaaactttaa atataaaggc aagtgattat ctaagcttaa ccttactaga ccatttagag
      781 tttttactta aaagatgtaa aaagaatcaa tttataaaaa gtcctttggt atggaatgtt
      841 aaaagatttt atccaaagca ttttgaaatt ggaatgcatg cactaaaatt aattggtgat
      901 agtaagggaa ttaatcttcc tgatgatgag gcagtatcaa tagcacttca ttttgtaaat
      961 atggaggtaa ataaagagtc tcatgatagt acaattgtag agttgagaac tttagcagat
     1021 atagtttcta taataaaata tcattttaat gtagagctag atgaaacttc aacaaattat
     1081 atgagattta ctactcatct acagtacttt atccaaagaa ttatgtcaga ggaagcttca
     1141 atagatgaag ataattctat agatttatat aaacaagtaa gtcaacttta tccaaagtca
     1201 tttggaagtg ttcaaaagat aagaaaatat ataaaatcac aatttaatgt cgatatatct
     1261 ataagtgaag aaacttattt aatgttgcat ataaataggg tgactcaaag actggaggca
     1321 aaatcagatg aaatataaag atttaaatga aaatataata aaacttatag ggggaaaaga
     1381 aaatataaag tcggtagcgc attgtgttac tcgtttaaga tttactttaa atgataggag
     1441 tatcgctcaa acagaagaaa ttaaaaaatt aaaaggagta attgatgtag tttctaatga
     1501 tgttgcttat caaattataa taggtactca tgttgtagat gtatataacg agtttatgtc
     1561 tatgataggt ttaagttcaa gtgaatcaag tataaaaagt gaaagaaaaa agggaattag
     1621 aggtatcaaa ggtatattta attccatctt tgtggtagtc tcagagacta tgacttcagt
     1681 aattgaagta ctacttgcag ctggtatact tgcaagtata ttagcacttt taaatatgtc
     1741 tggcatactt cagagtgaca gtcctacata tcaaatatta gatacattaa gaagtgctac
     1801 atttcacttc ttaccagtat taattgcaat agcatcagca aaaagactta atgtaaatcc
     1861 atatatagca gtagtattag cagttacgtt attatcttca tcaatagatg gtgtagaagg
     1921 attaagttta tttggtataa atttacagtc tacaacttat gcaaacagtt ttattccaat
     1981 acttttagga gtatgggcaa tgggaattat aattgaaggt ttgaaaaaaa tattacctaa
     2041 agcactacac tattttttag ttccagtatt atctttaata ataactctat cagttacatt
     2101 aactgtattt ggacctattg gtatgtggat tggtgatgga ttaaactatg catgtatgtt
     2161 tttaattgat acattgggta attggagtgt tgttgcactg tatgcagctt tacaaccact
     2221 cttaatagtc tttggtgcag caaactttac tatgcctata tctttaaatt ctgtgacaac
     2281 attggggtat gacccaattt ttatgggcgc tgcaacaata tctgatattg cagtttgtgg
     2341 tgcaatgttt ggatatttct taaaaactag gaataaagaa caaaaacaat tatttggtac
     2401 agtaagtttt agtgcactta tgggagttac agaaccttca gtgtttggtg tgtttatgaa
     2461 atatagaaga ccatttgtag cagtaatgat aggtggaggt ataggtggtt taatagcagg
     2521 tttagctcaa gttaaaacat atggaatggt ttggggatta gctgcattac caacgtatct
     2581 tgttggagga gaggtatcta actttacatt tatgataata agtgtagtag tatcatttgt
     2641 agcagcaaca gcagcttcct atttactagg aataccttca gatgaaaaag aagaagttaa
     2701 gggtgataat gaaaaagaat tagaactaat aatcaacgag aacaattcaa gaactattag
     2761 tattggaaat gttgcaaaag gtcaggtaat tgcacttggg gaagttaatg acaaagcatt
     2821 ttcctctgga gcattaggta aaggggttgg agttatacct agtgaatcaa aatcaactgt
     2881 tatatctcct gtagatggaa ctataactat agtatttcca actaaacatg catatggtat
     2941 agtgactgat gaaggattag aaatattaat tcatattggg atagatactg taaacttaga
     3001 tggaaaattc tttgaaagtc ttgtaacaca aaatcaaagg gttaaaaaag gagatgcttt
     3061 agcagtattt gaatctgata aaattataga ggaaggcttt gattctacta taataactgt
     3121 agttacaaat actagcgatt atttagatgt aatctcatca aatgatgaat cagaagaatt
     3181 attaactgta atagtataaa ttttaggagg gaaaattcat gaatattaaa gatacatttt
     3241 tctggggagg aagtattgca gcccatcaat gtgaaggttc atgggatagt gacaacaaag
     3301 gacctgcaat tatggatttt gtaactaagg gctcttatga aatgccaaga gtaattactg
     3361 ataaaataga agaaaaattg gattatccat ctcataatgg aatagatttt tataatagat
     3421 ataaagaaga tatagcttta tttaaagaaa tgggatttag tgcattaaga atatctatag
     3481 attggtcaag aatttttcca aatggagatg atgaaaatcc taatgaatta gggattaaat
     3541 actatgaagg tctgatagat acattaatag aaaataatat agaacctatt gtaacactat
     3601 atcattttga attacctatg aatttagtac ataaatatgg ttcatggaat aacagaaaac
     3661 ttatagattt gtatttaaag tacagtgaga ctgtaataag aagatttgat gataaggtaa
     3721 agtactgggt tacatttaat gagatgaacc atattgaccc tcaaacagag cactcggata
     3781 tttttactta tatgatagca ggtattaagt atagtgaaat agaaaataag gttcaaacat
     3841 tggcaaatgt agggtataat atgactttgg cgggtgtaaa ggttgcaaag ttggctagag
     3901 aaatcaatcc caacaataaa gttggatgtg tatttggact aaatccaatt tatccataca
     3961 attgtaatcc tagtaatgtg ttaaatgcat ttttagataa tgaccgtgat tattatcaaa
     4021 ttgatgcaat gtgcaatggg aagtttccac aatataaatt aaaagaatat gaaaaaaata
     4081 atataactat tgaagtgact gatgaagaca aaaaagcatt taaagaaggt aagttagatt
     4141 ttataggact taattattat ttttcaagtg tatctactcc aaaagaaaat ttatcaggtg
     4201 ataaatcttt atttggtggg attcaaaatc catatttgga acaaagtaag tgggggtggg
     4261 caatagaccc tataggttta agatttacct tgaactatat ttacagaaag tatcaattac
     4321 ctatcttaat tacagaaaat ggtttagggg catatgataa aatcgaagaa gatggaacta
     4381 taaatgatga ttatagaatt gaatatttag gtaagcatct atctcaaatg aagtctgcaa
     4441 ttgaagaaga taatgttgaa tgttttggat atttgatgtg gggaccaatt gatttagtca
     4501 gtgcaactac aggtcagatg agtaagagat atggatttat ctatgttgac ttagatgatg
     4561 aaggcaaagg aagttttaag agatataaga aaaaatcatt tgattggtac aaagaagtaa
     4621 taaaatctaa tggagaagtt ttagattttt ctacggatat agtagtaggg taggaataag
     4681 ataaatagaa gttaggaact aatgttaatt agtgtctagt aaagcattta aaatagagta
     4741 tagggtcttt aaagtaaagt gtgtattctt cttaaaagta atggcaacta aaattactat
     4801 aaaaaggaga atacacattt tttatgttta tacttaagta aatatttaga catattcata
     4861 gtataattta ctcattatat aaaaatagta tgatttactc actatataac tttataaatt
     4921 ttctggaaaa atgtcagaat atattgacaa agaaaagatt taaaattata atctatatta
     4981 agaatagttt gacaatataa aaacaagtat ttttataaat agtgaaatta tttttattgt
     5041 caatttaaga ataatttagg actactataa agataaaggt atagatgtca ttatatgata
     5101 aattatactt gtatagaaag aattttaaag tatggcttat cattgattta atataataaa
     5161 taatttttgt ttctagtaat agttcctagg aataagatat ctaaattcgt ttagaaatag
     5221 tctaatttac aaaggagggg atgcactaat agataaaatt tctatataaa gaagacttaa
     5281 agtgaagtat attctgataa tattggttta atgggtatat tattatttcg ttttagatat
     5341 tttaagaata atttaagacg tttataaaaa tgtattctat atctaatatt taaataaata
     5401 taagtcttcc aacatgtata ctaatataga gagtagttga agtacaattc taactcgtaa
     5461 aattatgtag aaagtaaaaa tcaaaaagaa atctagtaag ttgataacta tagttaatat
     5521 ttagagagtt aactctagtt atatttattt agatatttta ggaataattt aggacgtata
     5581 taatatcatc aaaaaatatc aagctatacc atatgtagtt aagaataact gcataatata
     5641 cattttataa ttattgtttt attgataaaa aattattata tttaggagga aacaacaatg
     5701 gaaaattttt ggaatccact tacttgcttt actgtatgtg taatgattta tgcttttagt
     5761 gagtttttat ctaagaaaac aaaaggtgca atttcaacat tgttatttgt atgtattata
     5821 tttttactag gattttggac aaatatttta ccaaaagaca ttacaggagc atcagggata
     5881 ttagctgcaa tgagcaactt tggtatagct ttattaataa ctaacttagg aacacttata
     5941 aatcttgaag acttatgtca tgaatggaaa acggttgtaa ttgcattagt aggtattgta
     6001 ggaataggag ttggctgttt aacagtgggt agtatgttat ttggcagaga gtatgcttta
     6061 atagcagcac ctccaatagc aggttctact gttgctggga ttatcgtaac aactgttgca
     6121 gaagctgcaa atagacctga acttgctgca tttgtaattc tagtattatc atttcaaaag
     6181 ttctttggta ttccgataac tacatattgt ataaataaag aattaaaatt taaaagagat
     6241 aacggggatt ttttgaaaga tgagtcaaaa agtaatttta aacttccaag tatgagaatt
     6301 tttaaagaag atttaggtaa aaaatcatct actctagtgt atcttgcaaa gctttcattt
     6361 gttgctatga ttggtaattt tgtaggattg gctactttaa taccaggatt tacccctgca
     6421 aactattatt taaatcctaa tatagcatgt ttgttagtag ggttgatttt tacacgaata
     6481 ggttttttag aaaaaggaat tttagataaa tctcaatcta atggaattat aatgtttggt
     6541 tgtatgttga tgttacctgg aggacttgct aaggtaactc caacagcatt gtttgggatg
     6601 attgttccaa ctataggaat acttgttgta ggttctgtat ttataatatt atttactgca
     6661 attgtaggaa aactattggg atattctcca agaatgtcag ctgcaattgg tgtaacttgt
     6721 atgctagctt atcctgcaac acagataatt tccaacgaag gtattgatgc tatggaagga
     6781 actgaagaag aaaaacaaag ggcaacagat tatttattac caaagatgat tataggagga
     6841 tttgttactg taaccattgc atcagtggca tttgctagta taataggtcc aattatattt
     6901 ggttgatagt aaatatactt ataggaggaa taggaaatga taggaagtat atctataaat
     6961 gagatagata aaaaaagatt caaacttgat gatttaagta agaaaatatg ggaaaatcca
     7021 gaaaaagcat ttaaagaatt taaagcatgt gaaaatacag caaactttct aagaagtgaa
     7081 ggatttgatg tggaagtagg tgtaggaggt ttagccacgg ctattagagc tagttttggt
     7141 tcaggtaaac cagttatagg ttttatggga gaatttgatg cattacctgg tttaaatcaa
     7201 aaagtttcaa caaagcaaga agcatttgaa ttgggtgcat atggtcatgg atgtgggcat
     7261 aatttattat gtacagcaca tgtaggggca gtagtagggc ttaaaagaga gatgatagaa
     7321 aataacttaa gtgggactat agtattttat gcatgtccag gagaagaaca attaacaggt
     7381 aaaggattta tggctagagg tggagcgttt gaagggttag acttagctat aaattttcat
     7441 ccaaataaaa ttagtgaagc tacaattggt acttcaacag ctgttaactc tgtaaagttt
     7501 cactttaagg gaaagactgc acatgcaggg tcagaccctc aaaatggaag aagtgcacta
     7561 gatgctgtgg aacttactaa tgtgggagct aattatttga gagaacatgt tacttctgat
     7621 gtaaggattc attatacaat tacagatgga ggagtagcac ccaacatagt tcctgataaa
     7681 gcatcagtat ggtattatac aagagcttta agtagagaag ctgtagaaag tacatatgaa
     7741 agacttgtaa aggtagcaaa aggagctgca atgatgactg aaactgaagt tgaagtagag
     7801 tttttaggag ggtgttataa tactttaaac aatcatgttt tagcaaatct tgtatcagaa
     7861 tgtatgaatg agattaaaca agagccttgg actcgagagg aattggattt tgcagctgaa
     7921 ttagatagac aaagcccaca acaatataag gctatgataa gtaaatataa tttgccagaa
     7981 ggaactcatc tatattatgg tggaggaaat gttacaaact ttaatagtta tggctctact
     8041 gatattggag atgtaatgca tatagttccg acagcatact tttttacagg gtgtacgaat
     8101 ctaggagcac caggtcatag ctggcagttt acatcttgtg caggaagttc tataggagaa
     8161 aaaggtatga tatatgcatc aaagattatg gctatgtttg gagctaaaat attaaataat
     8221 ccagagatag ctaaaaaggc aaaagaagaa tttgataaat ctatgaatgg taaaacatat
     8281 aaatgtccta ttccagatga tattccaact ccttaaaaag acatgaaatt taatatataa
     8341 aattataatt tttatatcag catcatttca ttactaaaag aaagtgagat tttgctgact
     8401 atctgattag gaggaaggaa tatgaaaaat ttttttaaag aagcgcagtc aatagaaggg
     8461 gaaattatta gatggagaag gtatttacat gaaaatcccg aaattggttg caatctaccg
     8521 aaaacagtaa cctttgttac cagtacttta gaaaaaatgg gatattctcc gaaattgacg
     8581 tctaataatg gaatagtagc tgttttagac agtgaaaatg gtggaaagac cttattatta
     8641 agggcagata tggatgcact tcctattagg gaggagacgg atttaccttt taaaagtaag
     8701 aataaagatg catctcatag ttgtggacac gataatcaca cagcaatgct cttaggagca
     8761 gctaaaatac ttatggataa taagcactta cttaaaggta gagtaaagtt tgtatttgaa
     8821 ccagatgaag agactaccag aggtgcaaaa tcaatgattg atgatggtat attagaaaat
     8881 cctcaggtcg atgcagctat ggcatttcac agtatggtgg gtaaatttct taacacaggt
     8941 caagtagctt attcacgtgg tccagctatg gcatctgcgg atatatttga aataacagta
     9001 gaaggaaaag caactcatgg agcaagccct gaatttggag tggacccaat aaacataatg
     9061 tcgcatatac aaatagcatt aaacactata ctttcaagag aaaaacctca gaaagagcct
     9121 gtagttttaa ctattggtat gtttaatgca ggaaacgtac caaatgctat accaaataaa
     9181 gcatctatgt caggaacttt aagaacattt gaccaatttg ttagagaaaa attaaaaaat
     9241 agaattattg aaatatctac aggaatagct aaatcatttg gaggaaatgc taaagtggag
     9301 tttaaaatgg ggactcctgc agttataaat gatttggatg taggagatga gattgtatct
     9361 tatgttaaag aagttatagg aaatgaaaat gtaatagact ttccatctgc aatgggttca
     9421 gaagattttt cagaggtttt actaagggtt ccaggagtat ttttatggat tggaatggga
     9481 agtattagtc agggatataa ttttggtatg cataatccta aagcaatttt taatgaagag
     9541 ggattagttt atggttcagc tttatttgct cattgtgcag taaaatggtt agaaaataat
     9601 tttagtagat aataacataa aatattatta aatatcataa aaggtatatc ttaaaaagat
     9661 gcaaagatat accttttaga aagtcatata taattttact taatattaga tgataaaata
     9721 tttttatgca ttttggattt taatatttat tttctgatat aaataatttg tatacccttt
     9781 caggtctgcc ttttgttgag ttttgttttt catataatat agtagcgttt ccagacttta
     9841 agagactact tagaaatcta ttagcagttc taactgttac atttaaacat gaagataatt
     9901 ccttaggagt aacttcatct ctttgtagaa tttcagtaac agatataatc ttttgaatag
     9961 taagagtaga caatttagaa cttttggcaa ttgtatttat atgtggagtt actttatttg
    10021 aaacagtaag taacttatca cacagtaaag gtcctattgt ctcataattt tcgttaacta
    10081 agaaactgta atttaaagga tttattttag attccttatt agcacttatg gcactagaca
    10141 tagcttgctt tatatcatta ccaattccat atccaataca tactttaata tttgtactat
    10201 tttcaataga ttcttttata taacatgcag taaaattttt agttaatgat ttaatcgttt
    10261 cacatttagt gaaaatttta aaagaattac tatttttttc aattataaaa tcggttaatt
    10321 tatctttttt aatactattt aatattttat aaacttggtc tagagtagag tcatcataat
    10381 ttgtatcttt aactgttata tatattacac ttggttgatt tcccttcatt ctatgtaaat
    10441 gaatatcttt tattaagtta ttaaaagtat tttttaataa atctatatca gggtatatga
    10501 aatgaaagtt tactcctgca ttttgtaaca taggaacaat actactaaaa cgagtagtag
    10561 aaaaatcgat tttcccttca ttccatagat taatatgttt ttttgcaatc tttttttcaa
    10621 gttttgctat gtcagataaa ctcattttag atgcattttc atcaatacta tccattaagt
    10681 ctccaaatgt gccatttgat aaataatatg atatatcttt tggattatct gcccagtctg
    10741 ttaagtcaaa gtatgctctg gaaaaatcta atgtattata tttaaagata agctttagaa
    10801 acatatcata gtaactttgt aagtcagtac caaaatcaac tagaggtttt ttaatagttc
    10861 cagccttttt tgtaatagct tttttgggga tggggccact aactgcaaat ccatcaaacc
    10921 tatcttctat ttctaaatat aaatctccaa catgagaaaa atctctatag atatatattt
    10981 caatttctgc attaatattt aactttttta tagaattatc tacaaactct tttaaaaatt
    11041 cggttgttat gactgctatt ttcatcatag attacttcct tttcaattat tataattatt
    11101 ttatattaaa tattacatta atctattgtt ctagttaaaa tcgtatttca attaaattca
    11161 attaaaataa ataactcttt ataaaaagca attatttagg tagaggaata tttgctaact
    11221 ttaatagtct ttgttaactt taattttatt taagttatta tagtcttact aattttataa
    11281 ttgtagattt aactacttta tgttctttta ttgtttatgt agttgattta gaagttattt
    11341 taaccattta ttttaattga agttgtttga cttttaaatc ctttgtgtaa tctttgtttt
    11401 tctagccatg ataaaagtat ttctatttgt atcactatat ataataatat catgacaaaa
    11461 tatttattgt ctaactaatt ataatctatc caaaatgaaa atgggtgtga gatattatta
    11521 caacaaattg tattagtatt aaaaagatta aaaaattaaa aaactaaaca gttaaataat
    11581 taaacgatta agtgactgtc atataacaat ttataatttt atttaacagc cacttaggta
    11641 tttaagagcg atagaattga gtgtatatca aattataata atttcctagt aaataattga
    11701 aaaataaggt agtccatttt tatatttgat atctggttta ccttgaataa gtggatatag
    11761 ataatttagg gcttcatcag ttatataatt acattcttca tttatccact ctttaggaaa
    11821 atattttgtc ttgttagcta ttttagaaat atcagtatga ctaacttcat acttataagg
    11881 attattgcat gttctattaa tgatagccat aactcctgta tatccttttt tagatagttc
    11941 tatcccatat gcaccaactt cagctgcttg ttttaaatca gtatctgaag ctaaatgcat
    12001 agcacatctt tgtattacac caagttctaa ggtttttact cttgttgtaa ttgatgatga
    12061 tactataaga ttctttagat agttgcttac tccacctaat tgggaatgac caaatttatc
    12121 atgagcagaa gttttttgtt cgcatataaa gttgccgtat ttatccctta taccttctga
    12181 tgcaactata taagccttat ttttttcttt aaatattttt ctaacatctt ctataaactt
    12241 atcttcatag aaatcaattt ctggaaggta tattaaatca acaagtggag tatcattaag
    12301 tctagctagt gaagaagaag ctgctaacca tccagtatct ctacccatag tttctactat
    12361 aaatatacca ttatttttgt atatagaaaa atctaagtat gtttccatta ttagtgtaga
    12421 aataagcttt gcagcagaac caaatccagg acagttgtca gttcctaata aatcattatc
    12481 tattgtttta ggaataccta taaattttat tttacaagta gtgtttttgc agtattgaga
    12541 aaatttcatc actgtgtcca tagaatcatt tccgcctata taaaataatg tatctatttt
    12601 atattcatct agtatattta taactctatc ataatcataa gaatttattt tataatcagc
    12661 cagtttgtat ctacaagaac caagaccaga cgaaggtgtt tgctttaaat ttaatacatt
    12721 atctttgttt aaggagtctg aatctattat atttttgttt aatatacctt caatcccatt
    12781 gataccaaaa tatactttat caaagtattt agtttctaaa tttttttcat aaataccaac
    12841 tgcagaagca ttgataacag ctgtagggcc tccagattgg gcaataatac agtttctcat
    12901 tttacatctc cctttcatta atattgttat gaatggtact ttttatcgag taaatttata
    12961 tttatagtct gattatatat taaatgaact agctatatca attgagttag tatagacaat
    13021 aaatgccata agaatgtggt aaaaaactaa ctttttatat acaattaatg tctataattt
    13081 accacaatat aaaggtactt ttaaggagta gtcaaagtgt tgtgaaaaaa aatatatcag
    13141 tgtaatatta atttacaaag caaaataagt tcacagttaa caaaagcaga ataagttcat
    13201 aaaagaaata tatacagcaa taaaagtaat gctaaataaa agtaatactg gattaaaaaa
    13261 tattaaaaaa atattaaaaa ctaatattta atactaatta aagtaaaata tggaggtata
    13321 caaatatgaa acacataaaa atagcagcag gattagcaca tgtaaattac ggtcatatat
    13381 cagccgtagt taaagaagca atggatgcag gtgtagacta cgtacattca gatgcagcag
    13441 atatgcatga cttaaaaaat atgcaactta tgggtggtca tcaaataata gaagcaataa
    13501 gaccggtgac agataaacca atagaatgcc atatatacac aagagattgt gatagattat
    13561 ttatagaaaa aatagcagca gcaggatgta acttgttgat aataccagca gaacattttt
    13621 taggtgctcc tcttgcatac ataataaatt actgtagaga atttggtatg aaagtaggat
    13681 taacaattgg atgttacaca ccactatgtt ttgttgatga agctatatat gatatagata
    13741 gattgcaaat agtcgttcat ggtgttgatg aaactgatgg aaaagataac tggggatgga
    13801 gaaagagtgc tgttgattta gtaaaaagag ctagaaaaat gatagacgaa aagaatccta
    13861 agtgtgaatt agcaatagat ggtggactaa gagcagacaa tatggagcca ttaatagaat
    13921 gtaatccaga cgttgtaata ttatcttcag caatattcaa ggataaagat ggtataacag
    13981 caggtgttaa gaattgtaga aaagctatag atgaagcagc tacaaagttt ggtttagaat
    14041 aagataataa actatgataa aagagatgct ttcttaatgt tttaaggaag cattaatttt
    14101 atgaaaaact acaggaagct agactaattt aattgatttt ttatactgaa acaatataat
    14161 cataggaggt tattaaatga aaaaagaaat gataaaagat tatttactga taacaatatc
    14221 agcattttta atggcattag cagttaattt tttctttgca gaacatacat tagctccagg
    14281 agggataaca ggattatcag tcgtacttag cacattctta tcaatgcctg ttgagaatat
    14341 atcattagga atatctatgc cacttttagt aatgggatta ttatttttag ggaaaggttt
    14401 tggaataaaa acattatata taactcttat gggcccatta ttcttaaaag taataccaca
    14461 aactcacata actgacaatc tattagtagc aggagtgata ggtgggttat tggtaggaac
    14521 tgctataggg atagcaataa taaggggctg tagtactggt ggaactgatt tagttgcaat
    14581 gcttattaat aaggtaatta agtttctgaa gttgccagtt atattattta tgctagatgg
    14641 atttataata gtagcgtctg gaataataag taagaatttt atgatatcta tatattcatt
    14701 gatatcttta ttactcataa taaaaacaat aggatttgta actacaaagt ttggtaagaa
    14761 tactgaagaa attaataata taaataatgc ttgtgctcaa taaaaataat aaaatttact
    14821 ttaaatataa aagtttaaaa aatataaaag cttaaataaa aagattaaat ataaaaaatg
    14881 aaggtgtctc aaaatgaatt ttttagttca tgaggcactt tttctatgaa atcaaatata
    14941 tttttatcat ttggacaatg aaaaataggt ttatctctat gttgagacaa gcctattttt
    15001 gtttatttat aagataatat tttatttttt tcagaatata gtttttttat aattgtacta
    15061 agtctagaaa tatcattctt acttaaaaga gcatttatat ttatcagttc agcattatgt
    15121 tcaaagtcta caggagcagt ggttagtatt aagtccacat catcaaagtt cgtaaatgaa
    15181 atagaagata gaggtataga tttaactata ttaatctgat taaattcaaa acttaacttt
    15241 tggactaata aattagatac accatcacta cagtgacata ttaaaatagt atttagggga
    15301 gatttgcttc tatctattgc tgatattaaa tataaagcaa gatatcctat ttcgtcatca
    15361 ttgacttcat aattcatcaa ctgtttgata acagtattag actctttagc agccttataa
    15421 gtgtaaggaa atgttctctt tatatcattt aatatgggat ttgtaatagt aaacccatag
    15481 tttattctgt gtagaactga tttaaggtga ttagcaagag actttattaa tattaaatca
    15541 tcctttaagt ttaaatttag tatacttccc caatgaacag ctattgcttc agatagatta
    15601 tactctgtaa tttcttcatt tttaagaggt tcaagagtag tagttttctt tattgattta
    15661 agtaatcctt ctatatgaag aaggatataa cagacctctt catcaataaa ttctacgtca
    15721 aaagcttcac ttaggttagc acataaaatt tttgattttt caaagtattc atgttctaat
    15781 aattctctaa aaaaaccttc agataagtta atatatcttt taattgaaat tcttttaata
    15841 catatagcta tatgtattaa gaagtttata taatactcat cactaaggtt acttttttct
    15901 acttgtaagg tgtgtagagt gatttgagat aatttctcaa aatcatagtt aaatagctcc
    15961 ttaaatattt ttgttgatgg ggtatctttg cattcattag atttcgagaa taatatttct
    16021 ttaagttcag tataactttt attaaccgta gcaagttcaa aaattgcttt tcgaatatct
    16081 ttctcttttc cctctaaata tactccatta ttggtttttc taactagagt cactttaaag
    16141 ttttgcaaaa aattttgaat aactaccaag tctttatgca cagtagctct actaacatgt
    16201 agttcattgc aaatatcacg aatcctaaac ttagaatttt taataaataa tttacttaga
    16261 atataccttt ttctatcttc aggagagtat gcatatatac aatttgattt atcattgata
    16321 tctctaataa ctttaagttt tatatcttca ttacctagaa taataacccc tgaaccagtt
    16381 tttttatcta gggataaatt aaactctaaa agccattcat ctaaaataac aaggtcatta
    16441 cgaatagttt tattactaac ttttaattct tcggcaatag tatctacagt aatatagtct
    16501 gagctgttga gtaataattc agcaatatct aataatcttt tgttcaatgc aaaccctcct
    16561 aaatcttagt tactatttat taaccttgga ccaatctctt tcaaaagtat tggcaccatc
    16621 tattgtaagc tggttaaaag aagctttttt aaataaatca tatgttacag ctgcataatc
    16681 acatccacaa agagatgctt gagttaagtg gaatacattt ttaatagaag ctgcaacaac
    16741 tttagtatta tatccattta ttgatataag gttacatatt tctgtaaggt tttttatacc
    16801 atcattccca ttttcatcat ttctacctat aaaagggaat aggtaatcag cacctgcatt
    16861 tatagctaat gatgcttgat ttacattgaa aatcaaggta catgcagttt ttacaccttt
    16921 actatttaat atgtttataa gttctaagcc aacttcagag aaatttattt ttattatagt
    16981 gtttttattt atatttaata tcttatcaca tgaattaatt aattcgtata aattatttcc
    17041 aatgacttca gcagttaata tttctggatt taaattagca catgtctcaa taaattcatg
    17101 gaagtttact ttctctttaa gatacataga tggattagcg gttattccct taaatccata
    17161 ctttagacac ttttgaattt catcaagatt agcactgtct atcaaatatt tcataattta
    17221 attctccttt aagctatttg tcataaaaaa gtgtatatac tctattttta ttattaagtc
    17281 aattatacaa taagattgat tataaaatta taacatgggt acttaataaa atttacataa
    17341 tgatatggta ataataaaac attgattgtc taataattac cataagcttt agtaaataag
    17401 agttaacagt gaaggtattg ccttaaaaat cctatgatat gtataatttg aatatgaagg
    17461 caataattta agggaggaaa aatatgatta acttttatca accatcaaga ataaattttg
    17521 gacaaggaac tttaagtgaa ttacctagaa taataggaaa atatggaaag aaatgtttgt
    17581 tagttactac tccaaatgta gagccattag acaagttata taaaagagtt acattgaatt
    17641 taatagaaaa aggtatagaa gttgtacact ttgattaaaa aatagctacg cacactcgtg
    17701 actttagtca tgagttaata gctaaaatag tcagcatata gggaaaccta tatgtagaga
    17761 taggatagaa cctatccaat actacttgaa ttgctggaaa cccctaaagc taaccaaact
    17821 aaaacataag gatgaaataa acctaagtgt gaaagttacg aaagtagaaa aaattggtta
    17881 gatggtataa ggttaaatcc taagtacttt aaaatgggca atcagcaggt aagctccgaa
    17941 taggagaaac ttcaacgact attcctcttg agggaagtac actacaagtt atcggtagtg
    18001 gaagtgggta gaccttaacg gataatgccg aaggataaga tatagtctgt gcttgcatga
    18061 aagtgtaag
//
LOCUS       DAEHWM010000092        17415 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.093, whole genome shotgun sequence.
ACCESSION   DAEHWM010000092 DAEHWM010000000
VERSION     DAEHWM010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17415)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17415)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17415
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.093"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            102..848
                     /locus_tag="KNP36_002989"
     CDS             102..848
                     /locus_tag="KNP36_002989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2087 domain-containing protein"
                     /protein_id="HBF0874840.1"
                     /translation="MKIENLSIDDIKRGYIFNDDLNCYSCIKCTKTYEVGEIYKIGNR
                     FFEASKAIELHMELEHSDYLEQLLNSDSKYNTLTENQKQLFQLFISDLPDKEIAKQVG
                     VSTSTIRHQKFIFREKAKQAKLYLALYESVFEDKSNKSSTIIPIHEHARMVDERYVVT
                     EEERKHILDTSFESMNPLKLKVFSSKEKKKVVILSKILEQFERGKKYSEKEVNQILES
                     IYDDFATIRRYLIEYGFMSRNKECTKYWLT"
     gene            909..1583
                     /locus_tag="KNP36_002990"
     CDS             909..1583
                     /locus_tag="KNP36_002990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase"
                     /protein_id="HBF0874841.1"
                     /translation="MNDELKSILYNKGVDIVRFVDISEFPINQTQGFSKAILFCIGLS
                     KKFITDIYNNLPTDSDEFLEKEEKAEELADWISEYIQNKGYRAYSQSEKNNLEHGYFE
                     KAYINPEMQSGISPLPHKTIANISGIGFMGKNNLFVTEEYGCAFSMCTVLTDAPISVE
                     RYPLIDSKCMDCNVCVENCPAKAIHGNEWTLPGKRESIIDVSKCFCVLKCMMSCPWSL
                     RYANQK"
     gene            1951..3297
                     /locus_tag="KNP36_002991"
     CDS             1951..3297
                     /locus_tag="KNP36_002991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBF0874842.1"
                     /translation="MEIETKTPDWINVLELNSKIDITGKYDVSNIIQDIVSDKSLEGS
                     IIYFPKGNYLFEKGIKISQQITLQGDSYYGGDNQVSNLDKKQSIIGTTNFITRGVSNM
                     SIIALTGTSQCIKNINFYYDSHDIEKIPPKNVSAITEYGETQGLSHFEHLFISGFSGI
                     GIEIPYYSTGNDIIVSSCGLGMRLGEKSMLSSSKIYECKNGMEITTGVSLNNVRIEEI
                     KEIGINNKGFGFNLIMNLMVDQCGYCGFMFEKMCYSQITARITRCGQYYKSVDYNAYE
                     NMEDRKEKAYSIFYGDILESCNIVLMNRNIDTLESDSLNEHKIYVIKANETNNVMLTC
                     YAEADNFIQCAKGNLLLENGENTYKFYNGEICSVGGVQISDIDEKDLIKIIENTLYID
                     DKGKYLMVPRLKKNTVIYSVLDSTEEINKLHGGIWEQIDVKVLAGESMYYYKKIKD"
     gene            3324..4724
                     /locus_tag="KNP36_002992"
     CDS             3324..4724
                     /locus_tag="KNP36_002992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBF0874843.1"
                     /translation="MEESIIIKDISGWINVLDYGICNDETKDVSFKLQEIMDAVPEDS
                     IIYFPKGKYLFESGVKIKKRLTLCGDSYILANVPKNTAGVTQFTFKGKKNPKSENRAI
                     ITAKSVRHCIKNICFYSDSCDRDMTSNHEPPTDGKPRFHHNVIINYRNISAVICEDKQ
                     GEPGHYENLSFSGFSGIALDMPNNSTANDITIFTSGLGISTGENSTIANSKVWGCVDG
                     MIISTGTFINGMRVEEIKKVGIKNIGRGLNFITNITIDQCGYCGVWFDSISNVQISGN
                     ITRCGQYYYDVSYDNYLMLDNRVKEAYSLFYGNLLESSNIVLSNTNEDNWEDFKEDKH
                     KVYLIEALKTKNVLLTCNIDATDWIVKSEKGNLTYNNMRQTVIFYDGKLSSINGIGIS
                     DEDYGDKVKIKKGNIYINSNDKDIKMHKPEVGDIMSTIIKDKSILSAHYGGTWEKIGE
                     KIEFGITVHYYKLIEK"
     gene            4934..6370
                     /locus_tag="KNP36_002993"
     CDS             4934..6370
                     /locus_tag="KNP36_002993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 55 protein"
                     /protein_id="HBF0874844.1"
                     /translation="MEGRTGIKDGRWINVVERGIKNDGSYNIGPALQDIIDEIETDFC
                     VLYFPKGKYLFTSGVKINKEIVLQGDSNSSTGTTQFITRGVENMSIITLTGKKQCIKN
                     INFYSDSCEIQVNKEPPTKGNPKYHYEMIINKNEKNVEMNNVSAILYDNSKNMIKGLG
                     HYENIYISGFSGTGIRIPYYSIVNDITVSSCGLGIDTGIDTIISNSRISKCQNGMRIR
                     TGTSINNVRIEKIQKVGLISSQVKGYEGYGSYKINNITIDQCGYCGFSFDSMKDSYFS
                     GIIRRCGQYYYNTDYDTYLSIKDRVEEAYSLFYGNYFTECNIDLVSDNKDNWDDGLEY
                     KHKVYVFKTLQIPKLTLRCNIDAYDYIVKSVHGGGNLMLKNNFNNYIFIDSSNPEVIN
                     GINFNYQKNGNLLRLNNGKLSYKNGKEETAIFRPNYGLIVASTDSECEQIEATYGEKW
                     EKLGSEVIGEETVYYYKHHEPDKTNQIQ"
     gene            6714..7658
                     /locus_tag="KNP36_002994"
     CDS             6714..7658
                     /locus_tag="KNP36_002994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1848 domain-containing protein"
                     /protein_id="HBF0874845.1"
                     /translation="MIVSVSRRTDIPAFYSKWFFNRLEEGFVYVINPMNPKQVSKIEL
                     NPHTVDCFVFWTKDVTPMLYDLNKLRDYKYYFHYTITSYGKEVETCILDKRKVIDSFK
                     ELSRKIGKERVILRYDPIFLSEKYTVDYHIKAFASLCNQLDGFTEKCIISFIDLYKKT
                     KFNTKALHIKPIEITEIETLSKEISKIAHKHGIILEMCSEEYNLSKFGIGKSKCIDDR
                     LISKIIGCEVEVKKDSTQRDICGCVKSVDIGQYNTCRHYCLYCYANFNYAKVEENCRL
                     YKEDNKLLIDTLRDDAKISIRDMKTIKVDKNKQISIFD"
     gene            7827..8759
                     /locus_tag="KNP36_002995"
     CDS             7827..8759
                     /locus_tag="KNP36_002995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HBF0874846.1"
                     /translation="MNLLKKYPIPIASLILSIFTLGNLLQSYSESLRNVIGFIGFILY
                     AIYIVKIILLRKGVKEQLENPLISSTFPTITMATMIFATYIKPLSLELSIMIWSIGIV
                     GHLVLIVLFSKKFLVKFSIKTVFPSWYIVYVGIVAASVTAPAFNQLLIGKIAFWIGFV
                     SYIVLIPVILKRVWIIKEMPEPSLPSIAILAAPGSLLLSGYINSFSDKNNVVLYLLFI
                     LSIVFYIIVLGYLPKLLRLPFYPSFAAFTFPMAISAMGMKLMNGYLTKSGHFISWISY
                     ASKLEEIIATVIILYVLVLFIIYLSKSETTSKAK"
     gene            8864..9331
                     /locus_tag="KNP36_002996"
     CDS             8864..9331
                     /locus_tag="KNP36_002996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C_GCAxxG_C_C family protein"
                     /protein_id="HBF0874847.1"
                     /translation="MKTKEEYLKEVRNISEEYFRKGEFFCSEAVLQTINDALGQPLSP
                     EITKLASGFPIGLGKAQCLCGAISGGEMALGIVYGRVHGEAMNPKMFEHAKGLHDYIK
                     KEYGATCCRAITKKWDGDNFMSPERKEHCIKITGQVTEWVADKLIEDEKLNIK"
     gene            complement(9575..10429)
                     /locus_tag="KNP36_002997"
     CDS             complement(9575..10429)
                     /locus_tag="KNP36_002997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009912760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose uptake protein"
                     /protein_id="HBF0874848.1"
                     /translation="MLTIIIALLPVMGWGLMPIVANLKKSSPHEQLLGTSISAFIFST
                     IITLVIHPEITFFSFCISMISGIFWSLGQLMQFKAIQIASVSKVMPISNGSQLTFTTL
                     LAVILFNEWTSSKMLLIGSLSILCIILGILLTNYQTKKSTDKNMLKCVGVVLLSSLFL
                     SLYVVTNQIFLIEGYRIILPQSVGMLITSSIIVKYFSKEIVYRENVLFNLITGILWSI
                     ANLGMFITTNTLGVTISFSISQSCVIVATLGGIIFFKEKKNKKEWLAIFIGIILIMSG
                     VFMLSIIK"
     gene            10595..12559
                     /locus_tag="KNP36_002998"
     CDS             10595..12559
                     /locus_tag="KNP36_002998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0874849.1"
                     /translation="MLTDMIQNREIKIIKFLLKEGHTTVKAIADDLDVSEKTVSKSLK
                     EVEAVLKKIGLSLIRKPKIGVYIDGDLKKILPYLDNKGSQIPTTREERVIYIYSVLLK
                     SNDYITIQQLSDELYISRGTIERDLAEVEKLLKNEGISIYKKPSKGIKLNISERDKRQ
                     LTAKFIHKFWSRNWYIKQEQESFYQAFEKIQADVNGIFSEDDLSIIIDILRNFSRERK
                     FEFSDYEFQSLVIHLAIAVERIRKGEYIEESLYTGNIENNQMSNTNYLAKQLEEKFSI
                     LLPKSEIGYINLHLVASDQHRDTNELKNTSTNPCETSTNNISNLREIIKNTLYETAYD
                     KDLIDGLTSHVHSSINRLKYGLSIKNPYVNTIKQNFSLSFEQALDLKKVIEFIYDIRI
                     NDDECAYIALHFEAFRERMKELPQNIRVILVCSTGLGSSRLLSARIKKYFPMIKIEKV
                     LSVQELVSSKIDADLVISTIYLELETIPTIVVSPILNESDIRTLERNIQNVSSYTSKK
                     YKSFRNLIFEENILLNIEASNYEDAIKYITDNLIKKGFAKEGIAKSAIERENLSYTSF
                     QSIATPHANPSYIKKSNISVATLKNPITWGNEKVEVIFFISLENDKNLELDEIYEVFY
                     DFIDNKKNINDILSATSTKEVYDLLVEESI"
     gene            12559..13020
                     /locus_tag="KNP36_002999"
     CDS             12559..13020
                     /locus_tag="KNP36_002999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0874850.1"
                     /translation="MKISDVLKKEQIVFNLDTNTKEETIKKLSSIFVENGIVDNEEEY
                     VKSVLEREEHSTTGIGNGIAIPHGKSNAVKKSSIIFAKTKHKIEWDALDEKPVDSIFL
                     LAISNIDKDSNHLVLLSKLATKLMDDDNVDALKLANSEQEIINIFSEEGEM"
     gene            13023..13343
                     /locus_tag="KNP36_003000"
     CDS             13023..13343
                     /locus_tag="KNP36_003000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_463956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBF0874851.1"
                     /translation="MKRKIIAVTACATGVAHTYMAAQALKKASKKMGHLIKVETQGAT
                     GIDNELTTKDAQIAEVVIFAVDTKVRNAERFEGKEILEVPVNAPIKDAEKVINDALKL
                     IDTK"
     gene            13359..14459
                     /locus_tag="KNP36_003001"
     CDS             13359..14459
                     /locus_tag="KNP36_003001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBF0874852.1"
                     /translation="MLKKIVSELKKHVLTGISYMIPLVIAGAMIMAISRVGGSFYNIP
                     DIWDAKYAESASSIVRLLHDLDGFGGTALGLMFPVIAAFIGFSIADKLAIVPGLVGGM
                     IAKDIGAGFLGALAVGLIAGYTCLFIKNHVKLPKSAASIVPIFIVPVFGTLITVVLIN
                     YVIGIPFATLNTGLENWLNGLSGTNQILMAAIIGAMMAVDLGGPVNKAALTTSLALLT
                     SGIYAPNTAAMVGIVIPPLGLGLATILAKQKYNKQLREAGKSSLIMGLIGVSEGAIPF
                     AVESPLKVIPSCVIGTAIASAMAVGLGSVNATPISGFYGWFTVENWPMYVLSIAVGTV
                     IVAGLVIVLRGNPVIEDDEFEDDDFDEAEWES"
     gene            14579..17179
                     /locus_tag="KNP36_003002"
     CDS             14579..17179
                     /locus_tag="KNP36_003002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HBF0874853.1"
                     /translation="MIKAHIVNHTHWDREWYFTSGDALVLSEQLFTDVIDELERNPDV
                     SFVLDGQLSILDDYVQLHKEKIEIIKKLIKEDRLHIGPWFTQTDAFFARGESILRNLM
                     IGIFESKKYGKYMKIGYLPDTFGFNAQMPILLKHVGLDNIFFWRGIHLGKQVQSPYFK
                     WKSLNGESYIYAVNMPHGYGTGMLLEPSLKYVNGRLDPAIDFIKSYTDVDEVLIPSGN
                     DQLNIIGDFKNKIKAINDIGKYSYITSSYQEFLKYIKSIESLESYRGEFREPVLARIH
                     KSIGSSRMDIKLACDKLENKLIKRIEPLLVIAKKSKIEISNQLLINTWKKLLEGQAHD
                     SLAGCVTDTVTDDILHRIREANEICDSIENTIVKKISEGLKLSKNDILVFNTEAKRFN
                     GYKEIQVVSDSKNIYFKDNLDATIIEETYVKPRENVLEETPAGNIFIEEPGYYILKVR
                     INVQLPALGYKVVSFESSDKEMVSLNKSNDAFISNDNYKIIYEDGSLNLQLKDGTYIS
                     NFLTLKDSGNAGDTYDFSPLKNDEDIKLSFDKVYTEKALGYEKMVVKGTTLLPLTLED
                     RKNKYLNGKLNVKVSIVLSKENPLMDVKLCVDNTIYNHRLRVHIKTDIKDNKNIASLP
                     FGYITRENGVLDNWEDIYSEMPIDLEPLESNITLTNQNRSCTIFTKGIKEYQHIEDEI
                     ALTLLATTDELGKPDLLYRPGRASGDTTKKGHIRIKTDKAQMLKKLEFSFAIYMDSKS
                     FDELEIANLTHNYLRECVNYQLQDYNFFLYRIDNKIQKSIVNKTVSRELEIISLPENY
                     LISACYPSYYSKDKFIIRVENPSSNKMILDEQIFKNRNGKIVNAIEDVEEEQVYEIAP
                     FDVISILLDL"
BASE COUNT         6931 a         1785 c         3010 g         5689 t
ORIGIN      
        1 aattagattt gataaacaaa aaataaaaat gttgattata ttaataaact ttaatataat
       61 atatttatga aaaatgtaaa ctgtgaaatg gaggtagtaa catgaaaatt gaaaatcttt
      121 ctattgatga tattaaacga ggctatatat ttaatgatga tttaaattgt tatagttgca
      181 ttaaatgtac aaaaacatat gaggtaggag aaatatataa aataggtaat agattctttg
      241 aagcttcaaa agctattgaa cttcatatgg aattagaaca tagtgattat ttagagcaat
      301 tgcttaatag tgattcaaaa tacaacacat tgactgaaaa tcaaaaacaa ttatttcaat
      361 tatttattag tgatttacca gataaggaga tagcaaaaca ggttggagta tccacatcta
      421 ctatacgcca tcaaaaattt attttcagag aaaaagcaaa acaggctaag ctctatttag
      481 cactatatga atctgtattt gaagataaat ctaataaaag tagtactata ataccaatcc
      541 atgaacatgc tcgaatggta gatgaaagat atgtagtaac tgaagaagag agaaaacaca
      601 ttttggatac atcatttgaa agtatgaatc ctttaaaatt aaaagtattt tcttcaaaag
      661 aaaagaaaaa ggtcgtaatt ttatctaaga ttttggaaca atttgaacgt gggaagaaat
      721 attcagaaaa ggaagttaat cagattttag aatctatata tgatgatttt gcaacaatta
      781 gaagatatct aattgagtat ggttttatga gtagaaataa agaatgtaca aaatattggt
      841 taacataatt aaaataataa attttactaa tgtgtaatgt tatttttatc tagggggagg
      901 agtcaaatat gaatgatgaa ttaaaatcta ttttatacaa taaaggtgtg gacattgttc
      961 gctttgttga tatatctgaa tttccaataa atcaaacgca aggtttttct aaagcaattt
     1021 tattttgtat agggttatca aaaaaattta ttacagatat atacaataac ttacctacag
     1081 atagtgatga gtttttagaa aaagaggaga aagcagaaga attagctgac tggatttcag
     1141 aatatattca aaataaagga tatagagcgt attctcaatc ggagaaaaac aatctagaac
     1201 atggatattt tgaaaaagcc tatattaatc cagaaatgca atcagggatt agtcctttac
     1261 cacataagac aatagcaaat attagtggca ttggatttat gggaaaaaat aatttgtttg
     1321 taacagagga atacggatgt gcttttagca tgtgtacagt acttacagat gctccaattt
     1381 ctgttgaaag atatcctttg attgattcaa aatgtatgga ttgtaatgtt tgtgtagaaa
     1441 actgccctgc aaaagctata catggaaatg agtggacttt gccaggaaaa agagagtcta
     1501 ttattgatgt ttcaaagtgt ttttgtgtat tgaagtgtat gatgagttgc ccatggtcat
     1561 taagatatgc aaatcaaaaa taattttact agagaaggta ttaaattgaa tattataaaa
     1621 tttttaaaat gtaagattat ataagatttt tcaaaataaa aatttgtata gaacactcag
     1681 aaatgagtgt ttttttattg gaattaaatt atattgatac aaagtttaac tattttaatc
     1741 attatataaa atttgtatta aaaaattaag aataacttgg taatagtgaa aatataatga
     1801 gattataatt gatttataat ataactataa tgatgttgta aaatgaaaat tgtcatttca
     1861 aaattcccaa aaagagtaaa agtcacttcg gttatagtca aaaaattttt tcagtgaaaa
     1921 gaatttagat ttaaaaggga ggaattaatc atggaaattg aaactaaaac tccggattgg
     1981 attaatgtac tagaattaaa cagtaaaata gatattactg ggaaatatga tgtaagtaat
     2041 attatacaag atattgtctc tgataagtca ctagaaggtt ccattatata ttttccaaaa
     2101 ggtaattatt tatttgagaa aggtattaaa attagtcaac aaataacact tcaaggagat
     2161 tcttattatg gaggagataa tcaagtatca aatttagata aaaaacaatc aatcatagga
     2221 acaaccaatt ttataactcg aggagtttct aatatgagta ttattgcatt gacaggaaca
     2281 agtcaatgta tcaaaaatat taatttttat tatgatagtc atgatataga gaaaataccg
     2341 cctaaaaatg tatctgctat tacagaatat ggagaaacac aaggactatc tcattttgaa
     2401 cacctgttta tttctggatt ttcagggata gggattgaaa ttccatacta ttcaactggc
     2461 aatgatataa ttgttagttc atgtggtctt ggtatgaggc ttggagagaa gtcaatgctt
     2521 tctagtagca agatttacga atgtaaaaat ggaatggaga ttactactgg tgttagctta
     2581 aataatgtga gaatagaaga aataaaagaa ataggtatta ataataaagg atttggtttt
     2641 aacctgatta tgaatcttat ggtcgaccaa tgtggatatt gtggatttat gtttgaaaaa
     2701 atgtgctata gccagataac tgccagaatt actagatgcg gtcagtatta taaaagtgtt
     2761 gattataatg cttatgagaa tatggaagat agaaaagaaa aagcttattc cattttttat
     2821 ggagatattt tagaaagttg caatattgta ttgatgaata gaaatattga taccttagaa
     2881 agtgattcac ttaatgaaca taagatatat gtaatcaagg caaatgaaac aaacaatgta
     2941 atgctaacat gttatgctga agcagataac tttatacaat gtgcaaaggg caacttgctg
     3001 ttagaaaatg gtgaaaatac ttataaattt tataatggtg agatttgttc tgtaggaggt
     3061 gttcaaattt ctgatataga tgaaaaagat ttaatcaaaa taatagagaa cactttgtat
     3121 atagatgata aaggtaagta tttaatggtt cctagattaa aaaagaatac tgtaatatat
     3181 tcagtactag attctacaga agaaataaat aaattacatg gtggaatatg ggaacagatt
     3241 gatgtaaaag tattagctgg ggaatccatg tactattata aaaagataaa agattaaatt
     3301 atcaaactag gaggtagtga ttaatggaag agtctataat aattaaagat ataagtggct
     3361 ggattaatgt acttgattat ggaatttgta atgatgaaac aaaagatgta agttttaagt
     3421 tgcaagagat tatggatgct gtaccagaag attctattat atattttcca aaaggaaaat
     3481 acttatttga aagtggtgtt aagattaaga aacgattaac cttatgtgga gattcttata
     3541 ttttagcgaa tgttcctaaa aatactgctg gagtaacaca gtttactttt aaaggaaaga
     3601 aaaatcctaa aagtgaaaat agagcaatca taacagcaaa aagtgtaaga cactgtatta
     3661 agaacatttg cttttattca gatagttgtg atagagatat gacatctaat catgaacctc
     3721 caacagatgg aaaacctaga tttcatcata atgtaattat aaattataga aatatatctg
     3781 ctgttatatg tgaagataaa cagggagaac caggtcatta tgaaaatcta tcttttagtg
     3841 gtttttctgg aattgcactt gatatgccta ataattctac agcaaatgat attacaattt
     3901 ttacatccgg acttggaatt agtacagggg aaaattcaac aattgctaac agtaaggttt
     3961 ggggctgtgt tgatggaatg ataatttcta ctggaacttt tataaatggt atgagggtag
     4021 aagaaataaa aaaagttgga attaaaaata ttggtagagg tttaaatttt attacaaata
     4081 tcacaattga ccaatgtgga tattgtggag tttggtttga ttctatatcc aatgttcaga
     4141 tatcaggaaa tatcacaagg tgtgggcagt actattatga tgtaagctat gataattatt
     4201 taatgttgga taatagagtt aaagaagcat attctttatt ctatggtaat ttattggagt
     4261 caagtaatat agttttatca aataccaatg aagataattg ggaagatttc aaagaagata
     4321 agcataaggt gtatcttata gaagcactta aaaccaagaa tgtactatta acatgcaata
     4381 tagatgctac tgactggatt gttaagtcag aaaaaggaaa tttaacgtac aataatatgc
     4441 gacaaactgt tatattttac gatggaaaac taagtagtat caatggaatt ggtatatctg
     4501 atgaagatta tggggataaa gtcaagataa aaaaaggaaa tatatatata aatagtaatg
     4561 ataaggatat taagatgcat aaaccagagg taggtgacat tatgtcaaca attattaaag
     4621 ataaaagtat tctttctgct cattatgggg gaacatggga gaaaattggt gaaaaaatag
     4681 agtttggaat aactgtacac tattataaat tgatagagaa ataagtaaat acgtagtatt
     4741 tgaatagatg tattttattg gagagttagg actatagttt taatataaat ggtttggtaa
     4801 tagcatggat tgaataatat aaaaataata taaaaaatta atttgattat gtaaatttct
     4861 atgaagtagt aaaactgtga ctttagtcat aggaggttca aactaagtaa aagggaaagg
     4921 aatatataat attatggaag gaagaactgg gattaaagat ggaagatgga ttaatgtagt
     4981 agaaagaggt attaaaaatg atggttcgta caacataggt cctgctttgc aggatattat
     5041 tgatgaaata gaaacagatt tttgtgtctt atattttcca aaaggtaaat acctatttac
     5101 aagtggtgtt aaaattaata aagaaattgt attgcaaggt gattctaatt catctacagg
     5161 tactacacaa tttataactc gtggagtaga aaatatgagt attattacat tgacagggaa
     5221 gaaacaatgt attaaaaata taaatttcta ttctgatagt tgtgagatac aggtaaataa
     5281 agaaccaccg acaaaaggta atcctaaata tcattatgag atgattatta ataagaatga
     5341 aaagaatgtt gagatgaata atgtatcagc aatcctgtat gataacagta agaatatgat
     5401 taaaggtcta ggtcattatg aaaatattta tataagtggt ttttcgggta caggaattag
     5461 gataccatat tactcaattg taaatgatat tacagtttca tcttgtgggc tgggtattga
     5521 tacaggaata gacacaatta tttctaatag tagaatatct aagtgtcaaa atggaatgag
     5581 gattagaact ggaactagta taaataatgt aaggattgaa aaaatacaga aagttggtct
     5641 tataagtagt caagttaagg ggtatgaggg gtatggaagt tataaaatta ataatattac
     5701 gattgaccaa tgtgggtatt gtggcttttc atttgattca atgaaagata gttatttttc
     5761 tggtattata agaaggtgtg gtcagtatta ttataataca gattatgaca catatttaag
     5821 tattaaagat agagtagaag aagcatattc tttattttat ggaaattatt ttacagaatg
     5881 taatattgat ttagttagtg ataataagga taactgggat gatggcttag aatataaaca
     5941 taaagtttat gtatttaaaa cccttcaaat accaaaatta acattgagat gcaatataga
     6001 tgcctatgat tatatcgtta aatcggtaca tggaggaggt aatttaatgt taaaaaataa
     6061 ctttaacaat tatatattta ttgattcatc taatccagaa gttattaatg gaattaattt
     6121 taattatcaa aagaatggaa acttgttaag gttaaataat ggtaaattaa gttataaaaa
     6181 tggaaaggaa gaaacagcta tattcagacc taattatggt cttattgtag catcaacaga
     6241 ttcagaatgt gaacaaatag aggctaccta tggagaaaaa tgggagaagc ttggttctga
     6301 agtaattgga gaagaaacgg tatattatta taaacatcat gaaccagata aaacaaacca
     6361 aatacaataa aatttgtatt atataatgat ataaagtttt aatatatagt gtttaccttt
     6421 aatgtaatat tggtatattt gtatagtatt aaatttgtta aaaagtaaaa ttgtagggtg
     6481 cttgaaaata gcaccttttt tagtttcatt ataaaattag ttttgaaagt ttaggaataa
     6541 tgtatattta tttttaaaga attataacct tattaaggat attttaaatg ctagaaatga
     6601 atcagtaaat catactggaa ttatcttaaa tgttttgatt aaattaagta tttagagcta
     6661 taattatatt aaaaatatat tagaacataa ttatattact atggaggtta aatatgatag
     6721 taagtgtgag tagaagaact gatatacctg ctttctatag taagtggttt tttaacagac
     6781 ttgaagaagg ttttgtttat gtaattaatc caatgaatcc aaaacaggtt agtaagatag
     6841 agttaaatcc acatactgtt gattgttttg tattttggac aaaggatgta actccaatgt
     6901 tatatgattt aaataaatta agagactata aatattattt tcactatact ataacatcat
     6961 atggaaaaga agtagagaca tgtattttag ataaaagaaa ggtaatagat tcatttaagg
     7021 aattgtctag aaaaataggc aaagaaagag taattttaag atacgacccg attttcttaa
     7081 gtgaaaagta cacagtagat tatcatatca aagcatttgc gagtttatgt aatcagcttg
     7141 atggatttac agaaaaatgt ataataagtt ttatcgattt gtataagaaa acaaaattta
     7201 atactaaagc attacatata aagccaatag aaattacaga aatagaaaca ttatcaaaag
     7261 agatttctaa gattgctcat aagcatggga taatacttga aatgtgttct gaagaatata
     7321 atttaagtaa atttgggatt ggaaaaagta agtgtattga tgatagatta atatcaaaaa
     7381 ttataggatg tgaagtagag gtaaaaaaag atagtacaca aagagatatt tgtggatgtg
     7441 ttaaaagtgt cgatatagga caatacaata cttgcagaca ttattgtctg tattgttatg
     7501 ctaactttaa ttatgcaaaa gtagaagaaa actgtaggct ttataaggaa gataataaat
     7561 tactcataga tactttaaga gatgatgcaa aaataagcat tagagatatg aagactatta
     7621 aagtagataa gaataaacaa attagtatat ttgattaaaa taaatatact aattacctta
     7681 atatattaag aatatagata cttttgataa caaaattaaa cttaatagat attttctata
     7741 taagaaagat ggtcataata tgtcaatttg accatctttt tgatataatt aaaacacaaa
     7801 taatttagta acaaaggagg cagaacttga atttattaaa aaaatatcct atacctattg
     7861 caagtttgat tttatcaatt tttactttag gtaacttatt acaatcttat agtgaatcat
     7921 tacgtaatgt aattggattt ataggattta ttttgtatgc aatttatata gtcaaaataa
     7981 tattacttag aaagggtgtt aaagagcaat tagagaaccc tttaatatca agtacatttc
     8041 caactataac aatggcaaca atgatatttg ctacatatat aaaaccatta tctttagaat
     8101 taagtattat gatttggagc ataggaattg tgggtcatct tgtgttaata gtcttattta
     8161 gtaagaagtt cttagttaaa ttctcaataa aaacggtatt tccatcttgg tatatagtat
     8221 atgttgggat agttgcagct agtgttacgg caccagcatt taatcaactt ttgattggca
     8281 aaattgcctt ttggatagga tttgtatctt atatagttct tataccagta attttaaaga
     8341 gagtatggat aatcaaggaa atgcctgaac catccttacc aagtatagct atattagctg
     8401 caccagggtc actattattg tctggatata ttaattcttt ttcagataaa aataatgtag
     8461 tattatactt gttattcata ttatcaattg tattttatat tatagttttg ggatatttac
     8521 cgaaattatt aaggttgcct ttttatccga gttttgctgc atttacattc cctatggcaa
     8581 taagtgcaat gggtatgaaa ctaatgaatg gttatttaac taaatcaggt cattttataa
     8641 gttggatttc atatgcttct aagttagaag agataattgc tacagtgatt attttatatg
     8701 ttttagtttt gtttattata tatcttagta aatctgaaac tacatctaaa gctaaataag
     8761 aattattaaa tatgtgtatt taataggaat attgatataa atatatgaag ataagataaa
     8821 ccatagaaac ttaatttagc ttaattttat tggaggaaaa caaatgaaaa caaaagaaga
     8881 atatttaaaa gaagttagaa acatatcaga agaatacttt agaaaaggag agtttttttg
     8941 ctctgaagca gttctccaga caataaatga tgctttaggc caacctttaa gtccagagat
     9001 aactaagtta gcatcaggat ttccgatagg acttggaaag gcacaatgtc tttgtggagc
     9061 aatatctggg ggagagatgg ctttaggtat agtatatgga agagttcatg gtgaagctat
     9121 gaatccaaag atgtttgagc atgctaaagg tttgcatgat tatattaaaa aagagtatgg
     9181 tgcaacatgt tgtagagcta ttacaaagaa atgggatggt gataacttta tgtctcccga
     9241 aagaaaagag cactgtatta aaataacagg tcaagttaca gagtgggttg cagataagct
     9301 tatagaagat gaaaaactta atatcaaata gtgtaatatt agttggtgaa tttataaagt
     9361 taaatttact tatagtataa gatacttgat attctcgtat tgatagaaaa atttatagca
     9421 tatgtattta atgaaatata cttatattta gagtgtggtt taatttcata aatacatatg
     9481 ctattatttt aagtatataa gcaaatttat ttaaataaat agaaacagtt aatttatatg
     9541 tacaaaacta tatatgatta gtgtaaataa atacctattt tataatactc aacataaaga
     9601 caccagacat gattagtatt ataccaataa aaatagcaag ccattctttt ttgttcttct
     9661 tttctttaaa aaatataatc cctcctaaag tggctactat cacacaactc tgagagatag
     9721 aaaaacttat tgtaactccc aatgtattag tcgttatgaa catacctaaa tttgctattg
     9781 accacaatat accagtaatt aaattgaata aaacattttc cctatataca atctctttag
     9841 aaaaatactt gacaataata gatgaagtta tcaacatacc aacagattga ggtaatataa
     9901 ttctatatcc ttcaattaaa aatatttgat tagttacaac atataatgat aaaaatagag
     9961 atgataataa tacaactcca acacatttta acatattttt atctgtagat tttttagttt
    10021 gataatttgt gagaagtata ccaagtatta tacataatat tgataaagaa ccaatcagta
    10081 acattttaga actggtccat tcattaaaca agattacagc taataatgtc gtaaaagtta
    10141 attgtgaacc atttgaaatt ggcattactt tagatacact agcaatttga attgctttaa
    10201 actgcattaa ttgtcccaaa ctccagaata tgccagaaat catacttata caaaatgaaa
    10261 aaaatgtaat ttcaggatgt ataaccagag ttattatagt ggaaaatata aacgcactta
    10321 tggatgtacc taaaagctgt tcatgaggag aacttttctt tagatttgca actatgggca
    10381 tcaatcccca tcccattaca ggaagtaaag caataattat tgtcagcatt aaactatttc
    10441 ctttcatatt aaatttagac agcttttaat ttatcatcta aaattaaagt gttcaataca
    10501 taaaaattac cgtatttaat caggaaatat tagtagtttt ttagaaaaac attttccatt
    10561 aaaataaaga caaagggaag gagtaaaatt gaaaatgtta actgatatga ttcaaaatcg
    10621 tgaaattaaa ataataaagt ttttattaaa agaaggtcat acaactgtaa aagcaatagc
    10681 agatgattta gatgtttcag aaaaaacagt ttcaaaatct cttaaagaag tagaagcagt
    10741 gcttaaaaag ataggtcttt ctttaataag aaaacctaag ataggtgttt atattgatgg
    10801 agatttaaaa aaaatacttc cttacctaga taataaagga agtcaaattc ctacaaccag
    10861 agaggagaga gttatctata tatattcagt acttttaaag agtaatgatt atattactat
    10921 acaacaactt tctgatgaac tatatataag tcgtggaact attgaaaggg atttagcaga
    10981 agttgaaaaa ctgctaaaaa acgaagggat ttccatatat aagaaaccta gtaagggaat
    11041 aaagttaaat ataagtgaaa gagataaaag acaacttact gctaagttta tacataaatt
    11101 ttggagtaga aactggtata ttaagcaaga gcaagaaagc ttttatcaag catttgaaaa
    11161 gatacaagca gatgtaaatg gtattttttc ggaagatgat ttatcaataa ttattgatat
    11221 tcttaggaat ttcagcagag aaagaaaatt tgagttctct gattatgaat ttcagtcatt
    11281 agttattcat ttggcaatag ctgtagagag aattagaaaa ggcgaatata tagaagaaag
    11341 tttgtatact ggtaatatag aaaataatca aatgtcaaat accaattatt tagcaaaaca
    11401 attagaagaa aaattttcaa tattattacc aaaatctgaa attggatata taaatttaca
    11461 tttagtagcg tctgaccaac atagagatac taatgaacta aaaaatactt caactaatcc
    11521 ttgtgagaca agtacaaata atatatcaaa tcttcgggaa attataaaaa atacattgta
    11581 tgagacagct tatgacaagg atttaattga tggattaact tcacatgtac attcatcaat
    11641 aaatagactg aaatatggac ttagtattaa aaatccatat gtaaatacaa tcaaacaaaa
    11701 cttttcttta tcatttgagc aagctttaga tttaaagaaa gtaattgaat ttatatatga
    11761 tattaggata aatgatgatg aatgtgctta tatagcatta cattttgaag cttttagaga
    11821 aagaatgaaa gaacttccac aaaatattag agtaattcta gtatgcagta caggattagg
    11881 ttcatctagg ttattgtctg caagaataaa aaaatacttt ccaatgataa agattgaaaa
    11941 agtactttcc gtacaagaat tagtatccag taaaattgat gcagatttag taataagtac
    12001 tatttattta gagttagaaa caattccaac catagtagtt agtcctattt taaatgaaag
    12061 tgatataaga accttggaaa gaaatataca aaatgtttca agttatactt ctaagaagta
    12121 taaatctttc agaaacttaa tctttgaaga aaatatattg ttgaatattg aagcttcaaa
    12181 ctatgaagat gcaattaagt atataacaga taacctaata aaaaaaggtt ttgcaaaaga
    12241 aggtatagct aaaagtgcaa ttgagagaga aaatttatct tacacttctt tccaatcaat
    12301 agctacacct catgctaatc ctagttatat taaaaaatct aatatatctg ttgcaacgtt
    12361 aaaaaatcct attacatggg gaaatgaaaa ggtggaagtt attttcttta tttcattaga
    12421 aaatgacaaa aacctagagc ttgatgaaat atatgaagtt ttttatgact tcattgacaa
    12481 taaaaaaaat ataaatgaca tattaagtgc aacttccaca aaggaagtgt acgatttgct
    12541 agtggaggag agtatatagt gaaaatatca gatgtattga aaaaagagca aattgttttt
    12601 aatcttgata caaatacaaa ggaagaaaca ataaaaaaat taagtagtat atttgttgaa
    12661 aatgggattg tggacaatga agaagaatat gttaagtctg ttttggaaag agaagaacat
    12721 tcaactacag gtattggtaa tggtattgct attcctcatg ggaaaagtaa tgctgtcaaa
    12781 aaatcttcta taatatttgc aaagactaag cataagattg aatgggatgc tttagatgaa
    12841 aaaccagtag atagtatttt cttattggct ataagcaata ttgataagga tagcaatcat
    12901 cttgtactat tatctaaatt agcaactaaa cttatggatg atgacaatgt agatgcacta
    12961 aaattagcca attcagaaca agaaataatc aatatattta gtgaagaagg agagatgtag
    13021 aaatgaaaag aaaaattata gcagttacag catgtgcaac aggagttgca catacatata
    13081 tggcagctca agcgttaaag aaagcttcaa aaaagatggg tcaccttata aaagttgaaa
    13141 cacaaggagc tacaggaatc gataatgagt taactacaaa ggatgcacaa attgcagaag
    13201 tagtaatatt tgcagtagat actaaagtca gaaatgctga acgttttgag ggaaaagaaa
    13261 tactagaagt accagttaat gcacctataa aggatgcaga gaaagtaata aatgatgcac
    13321 taaagttaat tgacactaaa taaatggagg gaaatgtaat gttgaaaaag atagtctctg
    13381 agttaaaaaa gcatgtctta actggaatct catatatgat tccattagta attgcaggtg
    13441 ctatgataat ggcgatatct cgtgtaggtg gttctttcta taatatacca gatatatggg
    13501 atgctaaata tgcagaaagt gctagtagta ttgttagatt attacatgat ttagatgggt
    13561 ttggaggtac tgcattagga ttaatgtttc ctgtaattgc tgcatttata ggattttcta
    13621 tagctgataa attagctatt gtaccaggtc ttgttggagg tatgattgct aaagatatag
    13681 gtgcaggatt tttaggagct ttggcagttg gtcttatagc aggatataca tgtttgttta
    13741 ttaaaaatca tgttaaatta ccaaaatcag cagcttcaat agtaccaata tttatagtac
    13801 cagtatttgg gacattaatc actgttgtat taatcaatta tgtgataggt ataccttttg
    13861 ccacattaaa tactggatta gaaaattggt taaatggatt atctggtaca aatcagatac
    13921 taatggcagc tattataggg gctatgatgg cagttgactt aggtggacca gttaataaag
    13981 cagctttaac aacatcactt gcattattaa caagtggaat ttatgcgcct aacactgctg
    14041 caatggtagg aatagttata ccaccactag gattgggact tgctactata ctagcaaaac
    14101 aaaaatataa taaacagtta cgtgaagctg gaaaatcatc tcttataatg ggtttaattg
    14161 gagtaagtga aggagcaatt ccttttgcgg tagaatctcc attaaaagta ataccttcat
    14221 gtgtaattgg aacagcaatt gcttcagcta tggcagttgg tttaggttca gtaaatgcaa
    14281 ctccaattag tggattttat ggatggttta cagtagagaa ttggccaatg tatgtgttat
    14341 caatagcagt tggaacagta attgtagctg gattagttat agtattgcgt ggaaatccag
    14401 tgattgagga tgatgaattt gaagatgatg attttgatga agcagagtgg gaatcttaaa
    14461 atttaataac tatttaagac gtgttataag ctatattcaa tatgaatctt atactaaata
    14521 aagtgttaaa cattcagttt agacttaaat ataaaagata aagaacagag gagaataaat
    14581 gataaaagca catattgtta atcatacaca ctgggataga gaatggtatt ttacttctgg
    14641 agatgcatta gtacttagtg aacaactatt tacagatgta attgatgaat tagaacgtaa
    14701 tccagatgta agttttgtac ttgatggaca actttctatt ttggatgatt atgtacaatt
    14761 acacaaagaa aaaatagaaa tcattaaaaa gttaataaaa gaagatagac tacatattgg
    14821 accatggttt actcaaactg atgcattctt tgctagagga gagtctattt taagaaactt
    14881 aatgattgga atttttgaaa gtaaaaagta tggtaagtat atgaaaattg ggtatttgcc
    14941 agatacattt ggatttaatg cacagatgcc tatactatta aagcatgtag gtcttgataa
    15001 tatattcttt tggagaggta tacatcttgg taaacaggtt caatcaccat attttaagtg
    15061 gaaaagctta aatggagaaa gttatatata tgcagtaaat atgccacatg gatatggaac
    15121 tggtatgctt ttagagcctt cattaaagta tgttaatgga cgcttagacc cagctattga
    15181 ttttattaaa tcatatactg atgtagatga ggtgttaata ccttctggga atgaccagtt
    15241 aaatataata ggtgatttca aaaataaaat taaagcgatt aatgatatcg gaaagtattc
    15301 atatataacg agttcatatc aagagttttt aaaatatata aagtccatag aatcactaga
    15361 aagctataga ggagaattta gagaacctgt attagcaaga atacataaat caattggttc
    15421 tagtagaatg gatataaaat tagcatgtga taaactagaa aacaagctga ttaaaagaat
    15481 agagccatta ttagtaattg ctaaaaagag taaaattgaa ataagcaatc agttacttat
    15541 aaatacatgg aaaaaacttt tggaaggaca agcacacgat agtttagctg gatgtgtaac
    15601 tgatactgta acagatgata ttcttcaccg tataagagaa gcaaatgaaa tatgtgacag
    15661 tattgaaaat actattgtaa aaaagatttc agaagggctt aaattatcta aaaatgatat
    15721 tttagtattt aatacagaag ctaagcgttt taatggatat aaagagatac aagttgtaag
    15781 tgatagtaaa aatatttatt ttaaagataa tttagatgct actataattg aagaaactta
    15841 tgtaaaaccg agagaaaatg tattagaaga aacacctgct ggtaatatat ttattgaaga
    15901 accaggatat tatatattaa aagtaagaat aaatgtacag cttcctgcac ttggttataa
    15961 agttgttagt tttgaatcaa gtgataaaga aatggtgtca cttaataaat ctaatgatgc
    16021 ttttatatct aatgataatt ataagataat atatgaagat ggaagcttaa atttacaact
    16081 taaagatgga acttacatat caaacttttt aacattaaaa gatagtggta atgcaggtga
    16141 tacctatgac ttttctccac taaaaaatga tgaggatata aaactttcgt ttgataaagt
    16201 gtatacagaa aaagctttag gatatgaaaa aatggtggtt aaaggtacta ctttactacc
    16261 acttacgtta gaagatagaa aaaacaaata tcttaatggg aaattaaatg taaaagtaag
    16321 tattgtctta tccaaagaaa atccattgat ggatgtaaaa ctttgtgttg ataatacgat
    16381 atataatcat agactacgtg ttcatataaa aactgatata aaagataata aaaacatagc
    16441 atcattgcca tttggatata taacaagaga aaatggagtt ttagacaact gggaagatat
    16501 ttacagtgaa atgcctatag atttagaacc tttggaaagt aatattactc taacaaacca
    16561 aaatagaagc tgtactatat ttactaaagg aataaaagag tatcaacata ttgaagatga
    16621 aattgcattg accttacttg ctactacaga tgaactagga aagcctgatt tattatatag
    16681 accaggacgt gcttctggtg atacaactaa aaaaggtcac ataagaatta aaacagataa
    16741 agctcaaatg cttaagaaat tagaattttc atttgcaata tatatggatt ctaaatcatt
    16801 tgatgaattg gaaattgcga atttaaccca caattatcta agggaatgtg taaattatca
    16861 attacaggat tacaatttct ttttatatcg tatagataat aagattcaaa aatcaattgt
    16921 caataaaact gtaagtagag aattagaaat aatatcttta ccagaaaact atcttatatc
    16981 agcatgttat ccttcttatt acagtaaaga taaatttata ataagagtgg aaaatccaag
    17041 tagtaataaa atgatattgg atgagcaaat atttaaaaat agaaatggga aaattgtaaa
    17101 tgcaatagaa gatgtagaag aggaacaggt atatgaaata gcaccttttg acgttatttc
    17161 aatattattg gatttataag tgtaaaagta agtttattgt ttaaagtctg acagatatta
    17221 atctgccaga ctttttaatt tgtataaatt tgggtaaata ttaatgaatg gttttagtat
    17281 ttaagtatga atttagtatt taatatagaa tttattgaag tagaataatt agtttaacag
    17341 gataagcagt ttaaataaag aattattata ttagagtgat tttatatata atttaagata
    17401 ataaaatttt aataa
//
LOCUS       DAEHWM010000093        17080 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.094, whole genome shotgun sequence.
ACCESSION   DAEHWM010000093 DAEHWM010000000
VERSION     DAEHWM010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17080)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17080)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17080
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.094"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(174..698)
                     /locus_tag="KNP36_003003"
     CDS             complement(174..698)
                     /locus_tag="KNP36_003003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBF0874854.1"
                     /translation="MENKNPIVTIEMENGKEIKIELYPNIAPNTVKNFVSLVNEGYYN
                     GIIFHRVIPGFMIQGGCPNGTGMGGPGHSIKGEFSGNGFTNNLKHERGVISMARTMAP
                     NSAGSQFFIMHKNSPHLDGQYAGFGRVIEGMDTVDEIASVRTDSADKPQTPQVMKSVT
                     VETFGIDYSDVEKN"
     gene            complement(763..1515)
                     /locus_tag="KNP36_003004"
     CDS             complement(763..1515)
                     /locus_tag="KNP36_003004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="patatin-like phospholipase family protein"
                     /protein_id="HBF0874855.1"
                     /translation="MKLGLCLEGGGAKGAYQAGVVKALYDGGINKFYSISGTSIGAIN
                     GYYLYTGNVDNLEKMWTNIKDIQNGNVKIVNNTVDNSPAIDNLRELDDSNIEEMNFYV
                     NYVEVDNKVVSEKIVDVSKMPRNEAIISISYSGLLPSNPNATLGFKEQFVKDVQEGIY
                     DGFKLDGGLIRSALIEPLIGDNVDKIILISTKYNYELPEDIKKVYDEDKIIVVRPNTQ
                     FAPKDTLNFDDEFCKTIYQEGYEIGKNILDRL"
     gene            complement(1546..2844)
                     /locus_tag="KNP36_003005"
     CDS             complement(1546..2844)
                     /locus_tag="KNP36_003005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M18 family aminopeptidase"
                     /protein_id="HBF0874856.1"
                     /translation="MDSINFAKNLIDFIYDSPSSFHAVESTKEILDKNGFEELVLNQR
                     WNLRVGGKYYVTKNLSAIVAFVVNSEGIERDGFRIIGSHSDSPTFSIKPNAEIEAEKS
                     YLKLNTECYGGAILSTWLDRPLGIAGRVVLKGDSILKPNERLIDFKKPICIIPNLAIH
                     LNRSINDGHSYNKQKDMLPLVGMLNDTLEKDNFLIKQIASNLDVNMDDIIDFDLFLYE
                     FEKGSLIGANDEFISIGRQDNLAMVHASLNALVNTKGQHGVNVMAVFDNEEVGSSTKQ
                     GADSNMLLNILERICISMGKDREGFFESIYSSFMISSDLAHAIHPNIPEKHDPTNKPI
                     MGKGPVIKINASQAYTSDGYSIAIYKNICREANVEYQEFVNRSDERGGSTIGPISSTH
                     IDIPSVDVGSPILAMHSIRELGNVEDHYSIYKTFSKFFEI"
     gene            complement(2861..5125)
                     /locus_tag="KNP36_003006"
     CDS             complement(2861..5125)
                     /locus_tag="KNP36_003006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3553 domain-containing protein"
                     /protein_id="HBF0874857.1"
                     /translation="MNLDTLNPAQREAVEKTEGPVLILAGAGSGKTKVLTTRIAYLIE
                     DKGVQAPNILAITFTNKAANEMRERVEQNIGPETKDMWISTFHSCCVRILRKDINKIG
                     YNRSFVIYDSADQVTLVKDCLKELNLSDKVFEPKAVISAISGAKDKLYTPKQFKDINM
                     ADNRMVKIADIYALYQDRLKRNSALDFDDLILKTVELFKANDEVLAYYRSRFRYIMVD
                     EYQDTSKAQYELIKLLAREHQNICVVGDDDQSIYGWRGADIRNILEFEKDYDNVHVVK
                     LEQNYRSTQVILDAANKVISNNIERKRKKLWSEKKEGELIKIQLTGSEIEEADFIADS
                     IAQIARKENRPYKDFAVLYRANAQARPVEDALNRSQIPYNIYGGTKFYERKEIKDLLA
                     YLRVIQNPQDDISIKRIINVPRRGIGLRTIEKIEDRANLKQESIYSVLIDIETNSDIS
                     TKARASISGFVDIIGTLRTIKEVYPVSKLIEKVLDTTGYMDELVEIRNKNEKDLTGKG
                     EEAQDRIDNLREFISIALEFESSNDDTYENKDLETFLTSIALTSESNDEEDNDRVSLM
                     TIHTSKGLEFPVVFLTGMEEGLFPISRAIKSMSDSQIEEERRLCYVGITRAKEELYMS
                     LTEKRTLYGKTNVAIASRFMEELPEECIERLYKVKKELSYSKASYNMLDKYTKKYMST
                     ISKSKVADKVNATIKDSNKETNPDDIKLGSKVHHPKFGVGTVVSIIGTDVTIAFDQQG
                     IKKINKEYTTLNIL"
     gene            complement(5380..6198)
                     /locus_tag="KNP36_003007"
     CDS             complement(5380..6198)
                     /locus_tag="KNP36_003007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     ATP-binding protein"
                     /protein_id="HBF0874858.1"
                     /translation="MFKINNLTYQYEKNTNALLNINMDFSKGNVIGIIGSNGSGKSTL
                     FMNLMGILKPTSGEILFKEEKLKYDKRSLYNLRKNVGIVFQDPEKQIFYSKVYDDIAF
                     AMRNIGMDEKTIKERINKALVAVNGIDFIDRPVHFLSYGQKKRVAIASVIAMENEIVL
                     LDEPTAGLDPVSTRSIVDIIKGLNKNNIKIVISSHDMNLMYEICDYIYVLDKGILIDE
                     GKAENVFINENNIIQAGLESPWLVKVHRNMNLPLFKKEEDLYKYWKERELNTNK"
     gene            complement(6191..6889)
                     /gene="cbiQ"
                     /locus_tag="KNP36_003008"
     CDS             complement(6191..6889)
                     /gene="cbiQ"
                     /locus_tag="KNP36_003008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt ECF transporter T component CbiQ"
                     /protein_id="HBF0874859.1"
                     /translation="MLIIDKYAYTNRLSKVNPNKKVAIGVIFLIASMVIQNIFILSGI
                     MILMSILVVCVAGIDLKNYLKLLRIPMYFLFLSIGITLVNISFNKADLLYSFEFFSFN
                     VGISKASINMSIHVLFRAMSCLTCVYFCILTTPFNQLIFFFKKLHLPDTFVELSMLIY
                     RFIFIFLEEFSEIYKSQELRFGYINLKTSYKSLGILGSMLYKRLMTRYDDMCISLDIK
                     LYDGKFHIVGDNDV"
     gene            complement(6892..7176)
                     /locus_tag="KNP36_003009"
     CDS             complement(6892..7176)
                     /locus_tag="KNP36_003009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0874860.1"
                     /translation="MSAKTKTKTNILLLLLVVALIIFPLLVNSGAEYGGADGQAESEI
                     TKINPNYKPWFSSPYEPPSGEIESLLFSAQAALGAGVIGYILGLQKGKRS"
     gene            complement(7166..7918)
                     /locus_tag="KNP36_003010"
     CDS             complement(7166..7918)
                     /locus_tag="KNP36_003010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006440549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor ABC transporter permease"
                     /protein_id="HBF0874861.1"
                     /translation="MKQNIKLGVIAALMLIILTPVTSNAMHIMEGYLPVKWSIAWGVI
                     FIPFFLFGLKSIGKIVKQDPKKKVLLALCGAFVFVLSALKIPSVTGSCSHPTGVGLGA
                     IMFGPSVMFVLGTIVLIFQALLLAHGGITTLGANAFSMAIIGPIVSFLIFKALKKKDG
                     NNAIPVFLAAAIGDLATYTITSIQLALAFPDPSGGVMASAIKFLGIFFMTQIPIAIAE
                     GILTVIVYNLITENGEKSILENNDKGVKANEC"
     regulatory      complement(8100..8292)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
     gene            complement(8424..10196)
                     /locus_tag="KNP36_003011"
     CDS             complement(8424..10196)
                     /locus_tag="KNP36_003011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitric oxide reductase activation-like protein"
                     /protein_id="HBF0874862.1"
                     /translation="MKWIYDDYEFENRANNLSWTIAGDYNESIDISEKDYSSKEIGLY
                     FAIIAGARRKYVDWDIVKKYLTNRIRKGYNKDVILGLIQVILNTIVEEKVIKDRPGIE
                     DIRRNAYKDIVSRFTKIHNDNIMDKIKYTFVLYSMDKHPALDSMTRRIVNDIRNIDTN
                     QDIMEILKALDVIYLTYFEYILNGEENSLIDENNVESVEVNFDTFADFMYEELYSDEE
                     ENIIESDIDSISSSMLVEGVGDFDDSKCSNSADRVIYVDEDTANKIYSKIEHYYGKTY
                     LSKGEIKKIETQNCRNVHEGCRIHFTDGVLRSECNNVFQLKYVTRQKENNLGKFREHA
                     RMYRQQIKRLKESLSRILIEENAKSRVYSDCGTILANRAWRVGRSNNNKIFYKDIENE
                     KGKYVIDILLDASGSQSRNQGNVAIQAYIIANALTEVGIPNRVMGFSSFLDYTILKRF
                     KDYDDSIKNSENIFEYFCAGNNRDGLAIKSICSGLINRDEENKILIVLSDGRPNDVKI
                     GKSSERTLRGEKAYRGIVGLRDTANEVRKARKQNILVLGVFTGKESELEAERLIYGND
                     FIYSRDITRFSDVVSMYLKKIIRN"
     gene            complement(10210..11139)
                     /locus_tag="KNP36_003012"
     CDS             complement(10210..11139)
                     /locus_tag="KNP36_003012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0874863.1"
                     /translation="MDIIDNLRVQGVDEKLIEDVLYFRNYYGLEKDLEYRVTKSKTYF
                     YGKDILSMCIAAILEEENILLSGPKATGKNLLADNLGEIFNRPQWNTSFHINTDSSTL
                     IGTDTFIDNEVKLRRGSVYECAINGGFGVFDEINMAKNDAIVVVHSALDYRRIIDVPG
                     YERVNLHPATRFIGTMNYEYAGTKELNEALVSRFMVIDIPPIEEDKLMMILKNEFSDA
                     DEEKLIHFAGIFLDLQLKSQNGEISSKAIDLRGLMASLKTIRRGLKPTLAINMGLTGK
                     TFDVYEKEMVGDVIKTRIPNKWESIDVFPISHI"
     gene            11360..11545
                     /locus_tag="KNP36_003013"
     CDS             11360..11545
                     /locus_tag="KNP36_003013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBF0874864.1"
                     /translation="MKYGCPEVAKKWGISERRVQKLCEESRIPGVSKLGYMWLIPKNA
                     EKPVDGRTKRRKEVQYE"
     gene            11538..12239
                     /locus_tag="KNP36_003014"
     CDS             11538..12239
                     /locus_tag="KNP36_003014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874865.1"
                     /translation="MNSVLIIDDDKELCALMKKCVEQENLSAITAHCGAEGLHLVDKN
                     RHTLSLVILDIMMPDIDGFQVLKKIRETSNIPVIMLTAKNDEDDKVSGLRLGADDYLT
                     KPFSINELMARVNSLIRRYTMLNPAFITDTDCIIINGMIIDKTNRIVSVNNIPVQLTS
                     KEFDLLAFLASNKGRVFTKKQIYTQVWEEEYAFDDSNIMSFISKLRKKIEPDPNHPFY
                     ILTVRGVGYRFNKEA"
     gene            12241..13164
                     /locus_tag="KNP36_003015"
     CDS             12241..13164
                     /locus_tag="KNP36_003015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874866.1"
                     /translation="MNTSVYLLLILVLSLIIIAYLVSVLLRVRIQLTLIKDALEDIKN
                     GNLNRRILTDENDITKQICYDINEIAINSQFQLIQQKQSEQAYKQLMTSLSHDVKTPL
                     ASLVGYLEAVESKIVVGEEKDEYIHVASNKAHYLKNFVENLFEWVKLDSKEQVFHFDI
                     FDLNELSRNIISDWIPVLESSHFEYEFDIPEIEYFLRIDANAYTRIINNLLQNIITHS
                     SGNKMTLRIFENKEQAQIIITDNGKGISSDNLPHIFERLYQCDHSRASKGNGLGLAIA
                     KELINAHKGNITANSTPGMGTEFTILLPKAL"
     gene            13321..14244
                     /locus_tag="KNP36_003016"
     CDS             13321..14244
                     /locus_tag="KNP36_003016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019639192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874867.1"
                     /translation="MNDFVIETKQLTKIYGNQTVVDKVNLHAKKGRIYGLLGRNGAGK
                     TTIMKMILGLTSITYGEVDVFGENIKGREKQVYPRIGAIIETPGFYPNLTGTENLEIF
                     AKLRGTAAPNSVKRALEIVGLPYKNKKLFSEYSLGMKQRLGIANAILHDPELLVLDEP
                     TNGLDPIGIAEMRKFIRDLSVEHGKTILISSHILSEISLLADDIGIIDHGVLLEESSM
                     SELEKKNSKYILLQVSDIPKTSLILERQFNTKDYSVQDDYTLHLYNTNLDMGEINKAL
                     VMQNVTVISSQLCNDTLEDYFKKITGGEGIA"
     gene            14237..14974
                     /locus_tag="KNP36_003017"
     CDS             14237..14974
                     /locus_tag="KNP36_003017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874868.1"
                     /translation="MLKLIQTEFLKLRRRKLIWLMLLSALIMPFFALLYFNYFGKTGV
                     EPIKFYKWSAFGYTLWIILPVVLGIFCTMLIHEENQYDMLKQLWIVPISKMGYFFSKF
                     FVVLIYSICFMLITAVASVLFSVLSGYVVFSWASILYLLKKCLEIGVITAFVMLPILA
                     IATSQKGYILPICITLVYAFSGFVIMTINMYLHPLSSMGVIIMRNKDIPGLIFSQEIN
                     VPLAFLCICIWSIVSVLFANTALGRRK"
     gene            14985..15758
                     /locus_tag="KNP36_003018"
     CDS             14985..15758
                     /locus_tag="KNP36_003018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874869.1"
                     /translation="MWKLLWAECQKIRRSKIVWITVFASIMIAVIVFAGGQDVYNDPD
                     LHYGLKSVYDGSRYIDNAGWYMDAVQPWSTFFVLPAVIALLGSYIICREEEEDTIKSL
                     RLIPINETKLTIAKMIITFIFSILLYLLLFTITFLTESVLHFSDLSTKLVLSCMKEYF
                     LDGIGVFFAISPIIALVSRMKKGYWLALVFTEVYSIAGLFAGMSNVLQTFFPIAAIFN
                     ISGYYITTGEKIMGSIISLLLCACLSAFILKGLKHNEKN"
     gene            complement(16299..16907)
                     /locus_tag="KNP36_003019"
     CDS             complement(16299..16907)
                     /locus_tag="KNP36_003019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DedA family protein"
                     /protein_id="HBF0874870.1"
                     /translation="MSVINSFILQYGLISVFVLIMIEYACFPLPSEVVLPLCGAIAAR
                     NHFGFLTILILSIIAGILGSIFCYTVGNWGGKSIINKIIEICPKAKKGIFASQDYFNK
                     YSSISVCVCRLIPLCRTYISFIAGIAGQNIITFVISSIVGITIWNTSLISIGYIFSES
                     WVRIMSHYNDYKFLVLIIPISIIFIGFVIKSFIHKKHHKIRL"
BASE COUNT         5509 a         2957 c         2156 g         6458 t
ORIGIN      
        1 aaactttatt ttttagttaa aatcatacaa tatatagatt tccacaatac aaataaatta
       61 aaaagtgaaa tgtatttgtc taaaaacata ataacatttc actttatcct catttttaag
      121 taatatatat ttttaatttt tatttataac taaatctagt ttttatataa attttagttt
      181 ttttctacat ctgagtaatc tattccaaaa gtttctacag taacagattt cataacttgt
      241 ggagtttgtg gcttatcagc tgaatctgtt ctaactgatg ctatttcatc aactgtatcc
      301 ataccttcta tcactctacc aaaacctgca tactgaccat ctaagtgtgg tgagttttta
      361 tgcattatga aaaattgaga accagctgaa ttaggtgcca tagttctagc cattgatatg
      421 actcctcttt catgttttaa attgttagta aatccattac cactaaattc accttttatt
      481 gagtgacctg gaccacccat tcctgtacca tttgggcatc ctccttgtat cataaatcct
      541 ggtattactc tatgaaatat tattccattg taatatcctt catttactaa tgatacaaag
      601 tttttaactg tatttggagc tatatttgga tataactcaa ttttgatttc ttttccattt
      661 tccatttcta tagttactat aggattttta ttttccataa tttattacct tccttttcat
      721 tagttaaatt acataattac atttattata ttatactcta aattaaagtc tatcaagtat
      781 attttttcct atttcatatc cttcttgata aatagtttta caaaactcat catcaaagtt
      841 aagcgtgtct ttaggagcaa attgagtatt aggtctaact actattattt tatcttcatc
      901 atatactttt ttaatatctt ctggcaactc ataattatat tttgtggata ttaaaataat
      961 tttatccaca ttatccccaa ttaatggttc aattaatgca ctcctaatta aacctccatc
     1021 taatttgaaa ccatcataaa ttccttcttg cacatctttc acaaattgtt ctttaaatcc
     1081 aagagttgcg tttggatttg atggtaacaa cccactgtat gaaatgctga taatggcttc
     1141 attacgaggc atttttgata cgtcaacaat cttttctgat actactttat tatcaacttc
     1201 aacataatta acataaaagt tcatttcttc tatattacta tcatctagtt cccttaggtt
     1261 gtctatagca ggagaattat ccacagtatt atttactatt tttacatttc cattctggat
     1321 atcttttata tttgtccaca ttttctccaa gttatcaaca ttccctgtgt acaaataata
     1381 tccatttatt gctcctattg atgtccctga aatcgaataa aatttattta ttcctccatc
     1441 atacaaggct ttaactactc ctgcttgata agcccctttt gctcctccac cttctaaaca
     1501 taatcctaat ttcatagtct catctccaaa ttgtttatct tatatttata tttcaaaaaa
     1561 cttactaaat gttttatata tactatagtg gtcctcaaca tttcctaatt ctcttataga
     1621 atgcattgct aaaattggac ttcccacatc cacagatggt atatctatat gagtagaaga
     1681 tattggacct atagtacttc ctcctctttc atctgaccta ttaacaaatt cttgatactc
     1741 aacattagct tctctacata tatttttata aatagctata gaatatccat cactagtata
     1801 tgcctgacta gcatttatct ttataaccgg accttttccc attattggtt tattagttgg
     1861 gtcatgcttt tctggaatgt ttggatgaat agcatgagct aaatctgatg atatcataaa
     1921 agatgaataa atagactcaa agaatccctc tctatcctta cccattgata tgcaaattct
     1981 ctccaatata tttaacaaca tgtttgaatc tgcaccttgt ttagtagagc taccaacttc
     2041 ttcattgtca aatacagcca ttacatttac accatgttga cctttagtat taacaagagc
     2101 attcaaacta gcatgtacca ttgcaagatt atcttgtctc ccaatagata taaattcatc
     2161 attagcccct attaaacttc ctttttcaaa ttcatataaa aataaatcaa aatctataat
     2221 atcgtccata tttacatcta agttagatgc tatttgcttt ataagaaaat tatctttttc
     2281 taatgtatca tttaacatcc caactaaagg taacatatct ttttgcttat tatatgagtg
     2341 accatcattt atacttctat ttaaatgtat tgctagattt ggtattatac aaattggctt
     2401 tttaaagtct ataagccttt catttggttt taatatacta tcacctttta aaactactct
     2461 accagctatc ccaagaggtc tatccaacca tgtacttaat attgctcctc catagcattc
     2521 tgtatttaac ttcaaataag atttttcagc ttctatttct gcatttggtt taatactaaa
     2581 tgtaggagaa tctgaatgag agcctattat tctaaatcca tctctttcta taccttctga
     2641 atttactaca aaagctacta tagctgataa attcttagta acataatact ttccaccaac
     2701 tcttagattc catctttgat tcaaaactaa ttcttcaaat ccatttttat ctaagatttc
     2761 cttagtactc tcgactgcat gaaaagacga cggactatca tatatgaagt ctattaagtt
     2821 tttagcaaag tttatactat ccattcctca tttacctcca ttataaaata tttagtgttg
     2881 tatattcttt atttattttt ttaattccct gttggtcaaa agctatagta acatctgtac
     2941 caattataga aaccactgtc ccaaccccaa atttaggatg atgtacctta gaaccaagtt
     3001 ttatatcatc tggattagtt tctttattag aatcttttat tgtagcatta actttatctg
     3061 caactttaga tttgcttata gtactcatat actttttagt atatttatct aacatattat
     3121 aacttgcttt agaatagctt agttcttttt ttactttgta caatctttct atacattctt
     3181 ctggcagttc ttccataaat cttgaagcta ttgcaacatt tgttttacca tataatgttc
     3241 tcttctctgt caatgacata tatagctctt ctttagctct agttatacca acataacaaa
     3301 gtcttctctc ttcttctatt tgtgaatcac tcatagattt tatagctctt gatataggaa
     3361 ataacccttc ttccatacct gttaaaaaca caacagggaa ctctaaacct ttggatgtat
     3421 gaattgtcat aagcgaaacc ctatcattgt cttcttcatc atttgattca gatgtaagtg
     3481 ctatacttgt taggaatgtc tctaagtctt tattttcata agtatcatca ttactacttt
     3541 caaactccaa agctatagaa ataaattctc tcaaattatc aattctgtct tgagcttctt
     3601 cacctttgcc tgttaaatct ttttcatttt tatttcttat ctctacaagc tcgtccatat
     3661 atcctgtagt atccaagact ttttctataa gtttgctaac aggataaact tcttttatag
     3721 ttctaagagt ccctataata tcaacaaatc cacttatact tgcccttgcc ttagtagata
     3781 tatctgaatt tgtttctata tcaattaata ctgagtatat actttcctgt tttaagttag
     3841 ctctatcttc aattttttct atagttctaa gccctatacc tcttctagga acatttataa
     3901 tcctttttat agatatatca tcttgtggat tttgaataac tcttaaatac gccaacaaat
     3961 cctttatttc ttttctctca tagaattttg taccaccata tatattgtat ggaatttgac
     4021 ttctatttaa agcgtcctct acaggtcttg cctgtgcatt tgctctataa agtactgcaa
     4081 aatccttata aggtctattt tcttttctag ctatttgtgc aattgaatca gcaatgaaat
     4141 cagcctcttc tatttcacta ccagttaatt gtatctttat aagttctcct tctttttttt
     4201 cactccaaag cttttttctt tttctttcta tattattaga tataacttta ttagctgcat
     4261 ctaatataac ttgtgtagac ctataatttt gttccaactt tacaacatgt acattgtcat
     4321 aatctttctc aaattcaagt atgtttctta tatctgcacc tctccatcca taaatacttt
     4381 ggtcatcatc tccaacaaca caaatatttt gatgttctct tgctaataat tttatcaatt
     4441 catattgagc tttacttgta tcttggtact catctaccat tatgtatcta aatctacttc
     4501 tgtaatatgc taacacttca tcattagcct tgaaaagttc tacagtttta agtattaaat
     4561 catcaaagtc aagtgcacta tttcttttta aacggtcttg atatagcgca taaatatctg
     4621 caatcttaac cattctatta tctgccatat tgatatcttt aaactgcttt ggagtataaa
     4681 gtttgtcttt tgctcctgaa attgcactta taactgcttt tggttcaaac actttatcac
     4741 ttaaatttaa ttcttttaga cagtctttaa ccaatgtaac ttggtctgct gaatcataaa
     4801 ttacaaaact tctattgtaa ccaatcttat ttatatcttt tcttagtata cgaacacagc
     4861 aagaatggaa tgtacttatc cacatatcct tagtttcagg acctatattt tgttcaactc
     4921 tctctctcat ttcatttgca gctttgtttg taaatgttat agctaatata tttggtgctt
     4981 gtacaccttt atcttctata agatatgcta ttcttgttgt taatacctta gttttacctg
     5041 aaccagcacc agccagtata agtactggac cttcagtctt ttctactgct tctctttgag
     5101 caggatttaa tgtatctaaa ttcatatttc tcctcctgtt aacagccata aatatatttt
     5161 aatctaaaat atgaattact tcaaattata attatgtatt atattaatag attatttcca
     5221 atatattaca attaaataac atttttccat ataatttatt tcattgttta ataaaaaaaa
     5281 taaccttatg atttggggaa tcataaggca cctttaaggg gtctaggtta agggttatta
     5341 tatataaatc tattttttta aaataggttt agggcttaat tatttatttg tattaagttc
     5401 tctttccttc caatacttat acaaatcttc ttctttctta aataagggta aattcatatt
     5461 tctatgtact tttactaacc atggggattc taggccagct tgtataatat tattttcatt
     5521 tataaacaca ttttctgctt ttccttcatc aatcaaaatc cccttatcca atacatatat
     5581 gtaatcacat atttcataca ttaaattcat atcatgactg gatattacta tttttatatt
     5641 atttttattt aatcccttta ttatatctac aatagaccta gtacttactg ggtctaaacc
     5701 agctgtaggt tcatcaagta atacaatttc attttccatt gctataactg atgctattgc
     5761 cactcttttt ttctgtccat agctaagaaa atgtactggc ctgtctataa aatctattcc
     5821 attaacagct actagagctt tgtttattct ctctttaatt gttttttcat ccataccaat
     5881 gtttctcatt gcaaaggcta tatcatcata tacttttgaa taaaaaattt gtttttctgg
     5941 gtcttggaag acaataccta cattttttct aaggttgtat aaacttctct tatcatattt
     6001 taacttttct tctttaaaaa gaatttctcc agatgtaggc tttaatatac ccattaaatt
     6061 cataaataat gttgattttc ctgaaccatt tgaacctatt atacctataa catttccctt
     6121 tgaaaaatcc atattaatgt ttaatagtgc attggtattt ttttcatatt gatacgttaa
     6181 attatttatt ttaaacatca ttatccccta ctatgtgaaa tttaccatca tacaatttta
     6241 tgtctaatga tatacacata tcatcatacc ttgtcataag tcttttgtac agcatacttc
     6301 caagaatacc taaggattta tatgaagttt ttaaatttat atatccaaat cttagctctt
     6361 gtgacttgta tatttctgaa aattcttcta aaaatatgaa tataaaccta tatattaaca
     6421 ttgataactc gacaaaagtg tcaggtaaat gaagtttttt aaaaaagaat attaattgat
     6481 taaaaggtgt tgtaagtata caaaaataca cacaagtcaa acaagacatc gctctaaata
     6541 acacatgaat agacatgtta atagacgcct ttgatattcc tacattaaaa ctaaaaaatt
     6601 caaaactata taataaatct gctttattaa aagatatatt tacaagagtt attcctatac
     6661 taagaaataa aaagtacatt ggtattctaa gtaattttaa ataatttttt aaatctattc
     6721 cagccacaca aacaaccaaa atactcatta aaatcataat tccacttaaa ataaatatat
     6781 tttgtattac catagaagca atcagaaaaa ttactcctat ggctactttt ttgtttggat
     6841 ttactttact caatctattt gtatatgcat atttatcaat tataagcatg attaacttct
     6901 ctttcctttt tgaagaccta atatgtatcc tattacacca gcccctaaag ctgcttgtgc
     6961 agagaataat aaactttcta tttctccact tggtggctca tatggactgc taaaccatgg
     7021 tttgtaattt ggatttatct tagtaatttc actttcagct tgaccatctg ctcctccata
     7081 ttcagcacct gagttgacaa gtaatgggaa tataataaga gctactacta ataaaagtaa
     7141 taatatgtta gtttttgttt ttgttttagc actcattagc tttaactcct ttatcattat
     7201 tttctagtat gcttttttct ccgttttctg taattaaatt atatacaatt acagtaagta
     7261 taccttctgc tattgctatt ggtatttgag tcataaagaa aattcctaaa aatttaattg
     7321 ctgaagccat taccccacct gatgggtctg ggaaagccag tgctaattgt attgaagtta
     7381 ttgtatatgt ggctaagtct cctattgctg ctgcaagaaa tactggaata gcattatttc
     7441 catctttttt ctttaaagcc ttaaatatta ggaatgatac gattggccct attatcgcca
     7501 ttgaaaaagc attagctcct aaagtagtta ttcctccatg tgctaataac aatgcttgga
     7561 atattaaaac tatagttcca agaacaaaca ttacgcttgg tccaaacatt attgctccaa
     7621 gacctacacc agtaggatgt gaacaacttc ctgttactga aggtattttt agtgctgata
     7681 atacaaacac aaatgctcca cataaagcta ataatacttt ctttttaggg tcttgcttta
     7741 ctattttacc tattgatttt aatccgaata agaaaaatgg tataaatata actccccatg
     7801 ctatagacca ttttactggt aagtaacctt ccattatatg cattgcattt gatgtaactg
     7861 gagttaaaat gattaacata agtgcagcta taacccctaa tttaatattc tgtttcatct
     7921 tagtatccct ctctcccttt ctaataatta aaacataata atacatgtct gatttattta
     7981 ataaaataaa aaagcctaac tcgatggtta ggcttctaat tttccacaat ctaaatacaa
     8041 acacataaaa caaacatatc tgtataatta ttataagaaa ctttctccat ccccgaagaa
     8101 attactttaa tattttaggc aggtctcctg acttagcttc atcctactcc ttttccttcc
     8161 catgagatat aaaaaatatc atcatagtgg ctaacaaaag tttcgtctgc atcacagtag
     8221 cgggggctgt aaaggaattt aacctttttc cctattaatc ttgcttaaag aacctataat
     8281 attatatatt taatttttaa attattctta aatcattttc tatataaatc attgtatacc
     8341 ttttctgtga aaatttctac attttttata aattttattc atttttatat ttttatgtat
     8401 ataaattctt ttttgtaagt ttattaattt ctaattatct tctttaaata cattgaaact
     8461 acatcagaaa atctagttat atctcttgaa tatataaaat catttccata tattaatctt
     8521 tcagcttcaa gttctgattc ttttcctgta aatactccta atactaatat attttgcttt
     8581 ctagcttttc tcacttcatt ggctgtatct ctcaaaccaa ctatacccct ataagccttt
     8641 tctcctctta atgttctctc actacttttt cctatcttta catcatttgg tcttccatcg
     8701 ctgagaacta tcaggatttt attttcttca tctctattta ttagaccact acatatagat
     8761 tttattgcca aaccatctct attattacca gcacaaaaat attcaaatat attttcacta
     8821 ttttttatac tatcatcata atctttaaat ctttttaata ttgtatagtc taaaaaacta
     8881 gaaaatccca tcactctatt tggtatgcca acttctgtta gagcatttgc aattatgtaa
     8941 gcttgaattg ccacatttcc ctgatttcta ctttgagagc cacttgcatc caataatata
     9001 tcaataacgt atttcccttt ttcattttct atatctttat aaaatatttt attattatta
     9061 cttctaccaa ctctccaagc tctattggct aatatagtac cacaatcaga atatactcta
     9121 cttttagcat tttcttctat taaaattctt gacagacttt cttttaatct ctttatttgc
     9181 tgtctataca ttctagcatg ttctctaaat tttcctaaat tattttcttt ttgtcttgtt
     9241 acatatttta gttgaaatac attattacac tcacttctaa gaactccatc tgtaaagtgt
     9301 attctacaac cttcatgaac atttctacaa ttttgtgtct caattttttt aatttcacct
     9361 ttactcaaat aagtttttcc ataataatgt tctatttttg aatatatctt atttgcagtg
     9421 tcttcatcaa catatataac tcggtctgct gaattgctac atttagaatc atcaaaatcc
     9481 cctacacctt ctacaagcat ggatgaagat attgaatcta tatcactttc aataatattt
     9541 tcttcttcat cactataaag ttcttcatac atgaaatcag caaatgtatc aaaatttact
     9601 tctacacttt ctacattatt ttcatcaata agactatttt cttctccatt taatatgtat
     9661 tcaaaataag ttaaatatat aacatctaat gcttttaaaa tctccataat atcttgattg
     9721 gtatctatat ttcttatatc attaactatt cttctagtca tactatctaa tgctgggtgc
     9781 ttgtccatac tataaagtac aaatgtgtat ttaattttat ccataatatt atcattgtgt
     9841 attttggtaa aacgtgaaac aatatcttta taagcattcc ttcttatgtc ttctatccct
     9901 ggcctgtctt taatgacctt ttcttcaact attgtattta atataacttg aattagacct
     9961 agtataacat ctttgttgta tccttttctt attctatttg taagatattt tttaactata
    10021 tcccaatcta catactttct tctagcacct gcaattattg cgaaatatag acctatttct
    10081 tttgaagagt aatctttttc tgatatatct atactttcat tgtaatcacc agctattgtc
    10141 catgataggt tattagctct attttcaaat tcataatcat catatatcca tttcataatc
    10201 tcacctatat taaatatgac ttattggaaa cacatctata ctctcccatt tattaggtat
    10261 tctagtttta attacatctc caaccatttc tttctcatat acatcaaaag tctttcctgt
    10321 aagtcccata ttaattgcaa gagttggttt taatcctctt cttatagtct taagagatgc
    10381 cataagacca cgtaaatcaa tagctttact agatatctct ccattttgag acttcaattg
    10441 taaatctaaa aatattcctg caaagtgtat taatttttct tcatcagcat ctgaaaattc
    10501 attttttaaa atcatcatta acttatcttc ttctatagga ggaatatcta ttaccataaa
    10561 tctagatacc agtgcttcat taagttcttt tgttcctgca tattcataat tcatagtccc
    10621 aataaatctt gttgctggat gtagattgac tctctcatac ccaggtacat caattattct
    10681 tctatagtct aaagctgaat gtaccacaac tatagcatca ttttttgcca tattaatttc
    10741 atcaaacacc ccaaaacctc cattaatagc acactcataa actgagcctc ttctaagttt
    10801 aacttcattg tctataaatg tatctgtacc tataagtgtt gaactgtctg tatttatatg
    10861 aaatgatgta ttccactgag gtctattaaa tatttcccct agattatcag caagtaagtt
    10921 ttttcctgtt gcctttggtc ccgataataa tatattttct tcttctaaaa tagctgctat
    10981 acacatagac aagatatctt taccataaaa ataagtttta gactttgtta ctctgtattc
    11041 taaatctttt tctaaaccat aataatttct aaaatacagt acatcttcaa taagtttttc
    11101 atctacccct tgcaccctta gattatctat tatatccata tttttacccc ttttatataa
    11161 atagtatttg tttcatttct tatcaccatt ttagcataaa aggatataag ctaaaattga
    11221 ttttttaatc tccccatttt aagtaaaacc atgcaccatt ttatcactac aaaattaaga
    11281 gtactactta ctgatatttc ttgattttgt tcgtctatac gtatataata tatgctgata
    11341 aattatgagg aaaggatgat tgaaatatgg atgcccagaa gtagcaaaaa aatggggtat
    11401 ttctgaaaga agagtacaaa aactatgtga agaaagtcgc ataccaggag tttcaaaact
    11461 cgggtatatg tggctgatac caaagaacgc agaaaagcct gttgatggta gaacaaaaag
    11521 aagaaaggaa gtacaatatg aatagcgttt tgattataga tgatgacaaa gaactttgtg
    11581 ctcttatgaa aaaatgtgtt gagcaagaaa atttatctgc tattactgca cattgtggtg
    11641 cagaaggtct acatttggtc gataaaaata gacacacact ctctcttgta attttggaca
    11701 taatgatgcc agatatagac ggttttcaag ttctgaaaaa aattagagaa acaagtaata
    11761 ttccagtaat tatgcttact gctaaaaatg acgaggatga taaagtttcc ggactacgtt
    11821 taggtgctga cgattaccta acaaaaccgt tcagcataaa cgaacttatg gctcgtgtca
    11881 attctcttat tcgtcggtat actatgttaa accctgcttt tataacagac acagattgca
    11941 taataataaa tggcatgatt attgacaaga caaaccgaat tgtttctgtc aataatattc
    12001 ctgttcaact tacaagcaaa gaatttgatt tacttgcttt tctggcttct aataagggac
    12061 gggtgtttac caaaaaacag atttatacac aagtatggga agaagaatat gcttttgacg
    12121 atagtaacat catgtctttc atcagtaaat tgagaaaaaa gattgaacca gaccccaacc
    12181 atccatttta tattttgaca gttcgtggtg tcggttatcg ttttaataag gaggcttaac
    12241 atgaatacaa gtgtctatct gcttttgata ttggttctta gcctgattat tatagcgtac
    12301 cttgtttctg tcctgctacg tgtccgaata caacttacac ttataaaaga tgctttagag
    12361 gatataaaaa atggaaacct taatcgacgt attttaacag atgaaaacga cattacaaaa
    12421 caaatttgct atgatattaa cgaaatagca atcaatagcc aatttcaact tattcagcaa
    12481 aaacaatcag aacaagccta caaacagcta atgacaagtc tctcccatga tgtaaaaact
    12541 ccacttgctt ctttggtcgg ttatttggaa gcagtagaaa gtaaaattgt tgtaggagag
    12601 gaaaaagacg agtatatcca tgttgcgtct aataaggctc attacttaaa gaattttgta
    12661 gaaaatctat ttgaatgggt aaaattggat tctaaggaac aagtttttca ttttgatatt
    12721 tttgacttga atgaattatc ccgtaatatt atatctgatt ggatacctgt tttagaaagc
    12781 agtcattttg aatatgaatt tgatatacca gaaatagagt acttcttacg tatagacgca
    12841 aatgcatata cccgtatcat taataaccta ttacaaaata ttattaccca tagtagtggc
    12901 aacaaaatga cattgagaat ttttgaaaac aaagagcaag ctcaaattat aataacagat
    12961 aatgggaaag gtatatcttc agacaatctc ccacatattt ttgaaaggtt gtaccaatgc
    13021 gaccattcac gagcttcaaa gggaaatggt ttaggcttgg cgattgcaaa ggaacttatt
    13081 aacgctcata agggaaatat taccgccaac agcactcccg gtatgggaac agaatttaca
    13141 atattgcttc ctaaagccct gtaaaagtac gaggctttct tactctaaaa caagataaaa
    13201 gcaagattat ggcaaggttt tggcaaggtt catgttttat aattctaatt gtagttgatt
    13261 ttgacgttgt atcaactatc ttttgtagaa acaaatttat taaaagtgag gaaattatat
    13321 atgaatgatt ttgtgattga aacaaagcaa cttacaaaaa tttatgggaa tcaaacagta
    13381 gttgacaaag tcaatctcca tgcaaaaaaa ggccgaatat atggtctgtt aggacgcaac
    13441 ggagctggga aaaccacaat tatgaaaatg attttaggat tgacttcaat cacgtatggc
    13501 gaggtagatg tatttggaga gaatattaag ggacgtgaaa aacaagtata tccccgtatc
    13561 ggtgcaatta tcgaaacgcc aggattttat cctaatctga caggaacgga gaacttggag
    13621 atttttgcaa aactgcgtgg tacagccgcc cctaattctg taaaaagagc attggaaatt
    13681 gtaggcttac cttataaaaa taaaaagctg tttagtgaat attcacttgg catgaaacag
    13741 cgacttggta ttgccaacgc tatcctgcat gacccagaac tgttagtttt agatgagcca
    13801 accaatggtc ttgaccctat tggtattgcg gagatgagaa agtttattag ggacttgagc
    13861 gttgagcatg gaaagacaat tcttatttcc agtcatattc tttcagaaat ctcattgttg
    13921 gctgatgata ttggaattat cgaccacggt gttcttttgg aagaaagtag tatgagtgaa
    13981 ctagaaaaga aaaacagtaa atatatcctg ctacaagttt cagatattcc gaagacatca
    14041 cttattttag agcgtcaatt taacacgaag gattattccg ttcaagatga ctacacgtta
    14101 cacctttata acactaatct ggatatgggt gaaatcaata aagcacttgt aatgcagaat
    14161 gtaactgtta ttagttctca actttgtaat gatactttag aggactactt taaaaaaatc
    14221 acaggaggag agggcattgc ttaaacttat tcaaacagaa tttcttaaac tgcgtcgtag
    14281 gaaacttatt tggctgatgt tgttgtctgc tctcattatg ccgtttttcg cactactata
    14341 cttcaattat tttggtaaaa caggtgttga gccaataaag ttttataaat ggtctgcatt
    14401 tggttataca ctttggatta ttttgcctgt tgttttgggt atattttgca ccatgcttat
    14461 acacgaagaa aaccagtatg atatgctcaa acagctttgg attgtaccta ttagtaaaat
    14521 gggatacttt tttagtaaat ttttcgttgt tttgatttac tctatttgtt ttatgctgat
    14581 tacagccgtt gcttctgtgt tatttagtgt actttctgga tatgtcgtat ttagctgggc
    14641 aagcatttta tatttgttga aaaaatgttt agaaattggt gtaatcactg cttttgtaat
    14701 gttgccgatt ttggcaatcg ctacatctca aaaaggatac attctcccaa tttgtatcac
    14761 attggtatat gccttttccg gttttgttat aatgacaata aatatgtatt tacacccatt
    14821 atccagtatg ggagttatta tcatgagaaa taaagacatt ccaggtctta tattttcaca
    14881 ggaaattaat gtcccattag catttctttg tatttgtatt tggagtattg tatcagtatt
    14941 gtttgcaaac actgcactag gaagaagaaa gtgaggtgta gataatgtgg aaattacttt
    15001 gggctgaatg tcaaaaaatt cgtcgttcaa aaattgtttg gattacagtt tttgcatcca
    15061 ttatgatagc agtcatagtt tttgcaggag ggcaggatgt atataatgac ccagatttac
    15121 attatggctt aaagagcgtt tatgacggtt cacggtatat agacaatgca ggttggtata
    15181 tggacgcagt acaaccttgg tcaacttttt ttgttcttcc tgctgtcatt gccctattag
    15241 gaagctatat tatttgtcgt gaagaagagg aggacactat taaatccctg cgtcttattc
    15301 ccataaatga aacaaaatta accatagcaa aaatgattat tacttttata ttcagtatac
    15361 ttctttattt gttactcttt actataacat ttttgactga atccgtttta catttttccg
    15421 atttatcgac aaaactggtt ttaagttgca tgaaagagta ttttcttgat ggcataggtg
    15481 tattctttgc aatttctccc attattgcct tggtatcgcg catgaaaaaa ggatattggc
    15541 ttgcattagt attcacagaa gtttattcta ttgctggact atttgcgggt atgtcaaatg
    15601 tcttacaaac cttttttcct attgcggcaa tatttaatat ttctggatac tatataacta
    15661 ctggagaaaa aattatgggg agtatcataa gtttattact ttgtgcctgc ctttctgcat
    15721 ttatacttaa agggctaaaa cacaatgaaa aaaattgaaa taggtatatc aaaatgaaaa
    15781 agataaaaaa actgattatt ctaattgtat tcttgtttct ttttggcatg ttacactgtt
    15841 atactgaatg gaaattcaac aataacccac ctaaaggggt aatagaaaga ataaatgaat
    15901 ggactgataa gattggactg gattagtaac ttatgttaat tatagtgaat gtaatattag
    15961 caagttattg tttcgtattt taatactata actttaaata tttggtttta atcttccaaa
    16021 cgaatataaa aaaactgtca cagaggcaac atatttttga atatttataa agtggtagtt
    16081 ttgattttca aagctgccgc cttttcttct atataagcaa acttatcctc aacaaagtgt
    16141 aaaacatggt acattttaag aaaaaagtac cacagacaca agcaataaaa gaaacgccga
    16201 gaacctacaa aaacgtagtg cttatgcaga tttacgacgc cttctatttt ctcaaccgtc
    16261 ttaatgacct tgtacaaaag aaatttttct aatatttttt ataatcttat cttgtgatgt
    16321 tttttatgta taaatgactt aataacaaat ccaataaaaa ttatggatat tggtataatt
    16381 agaacgagga atttataatc attataatgt gacattattc ttacccaact ctcagaaaaa
    16441 atatatccta tactgattaa tgaagtattc catatggtta ttcccacgat agatgatatt
    16501 acaaaagtta taatattttg acctgctata cctgctataa aagatatgta tgttctacat
    16561 aaagggatta atctacatac acaaacagaa atagaagagt atttgttaaa ataatcttga
    16621 gatgcaaata ttcctttctt tgcctttgga catatctcta ttattttatt tatgatagat
    16681 ttacctcccc aatttcccac tgtataacaa aatatcgaac caagtatacc tgcaattata
    16741 cttaaaatta aaattgtcag aaatccaaaa tgatttcttg cagcaattgc tccacataaa
    16801 ggtaaaacaa cttcgctagg taatggaaaa caagcatact caatcataat taatacaaat
    16861 acagagatta atccatattg taaaataaaa ctattgatta cagacactta cttatctatc
    16921 tcctttctta tttaaaggtt ttaagggtac atgttctaag gattctcacc ctatatttaa
    16981 agaatcaatc tctttaaact attatatgta tttacacaaa gcatttataa catactttaa
    17041 aaatagtacc ttaaaataag aaacttaata aataaaaaaa
//
LOCUS       DAEHWM010000094        17039 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.095, whole genome shotgun sequence.
ACCESSION   DAEHWM010000094 DAEHWM010000000
VERSION     DAEHWM010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 17039)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17039)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17039
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.095"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            62..691
                     /locus_tag="KNP36_003020"
     CDS             62..691
                     /locus_tag="KNP36_003020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874871.1"
                     /translation="MNKYLLINPVAERMYGEKFHLIKANLIKKGYIIAECEPQLEYVK
                     KQYKEYTKKTENTMLDCRCPESISLLKRNNLINDFEVPMIEPILVRTCRVLYDKYIKS
                     KDDMLVVTCPCTQLRDFASEKFKDKGNAMFYTWKEFAEQEGVKSLGKIDESPIPLGYF
                     KDTFEKVLEVSSEDEILSEIQKIRNGFEDKYDIVEMFYCKDGCNNGDGL"
     gene            692..1474
                     /locus_tag="KNP36_003021"
     CDS             692..1474
                     /locus_tag="KNP36_003021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874872.1"
                     /translation="MVNKFNNKFLRLVKSVLIFFIILLLWKITNYLGIWSDYILPSPE
                     KVYSTFLNMISDGSIFINVYASMKRVLIGFAISTAIGVPLGIFFGIYSGVYEYFKSLI
                     NFLRNTPPLALIPMLILWFGIGEESKIIIIVLASFFPIFTSTLKGIKNCDSKLIEVGR
                     VFEFSKLQIIFKIIIPNAILDIAVGLKLALGYSFRAIIGAELVAASSGLGYLISDGKE
                     MSRTDVVIVGIIVIGLLGIITDYIFSIIVKKVSKGKMVEAYE"
     gene            1467..2345
                     /locus_tag="KNP36_003022"
     CDS             1467..2345
                     /locus_tag="KNP36_003022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874873.1"
                     /translation="MNNLVCDSGYIIRNLYKSYKVDNEEHVVLSDISLNIDRNHITVI
                     LGESGCGKTTLLRAIASLEGINSGEIRFINDNKEYRPNVGFVFQESRLMPWLNVSENI
                     AFHNQRKNTILNKVLRKFKHNKRISSKIINDNFRSLETNDNLNKSNKYNRKSNIDVEK
                     YLKMMNLQKFKNSYPNELSGGMAQRVSIARALSFNPDMLLMDEPFSALDYFTRIDMQN
                     EVIRIHKSTNKGVIFVTHDIDEALKIGKKIVVFTDERKVKEFNIEDGYNRDLTSDYYI
                     KLKKDILMTMKSNKGI"
     gene            2378..3337
                     /locus_tag="KNP36_003023"
     CDS             2378..3337
                     /locus_tag="KNP36_003023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NrtA/SsuA/CpmA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0874874.1"
                     /translation="MKLKKLLIGITILTLATASLAGCAKKNNGEKLSEINLTYVKSPL
                     NVPSIIQKQDDLFGKEFKKDNIKVNFYEITTGPEQTQALAAGEIDFLHALGGTSALIA
                     ASNGVELKILNTYSRSPKGFMILTNNNSIKSAADLVGKKVAGPKGTILHQVLISALDK
                     EGLSMDDVEFVNMGIPEASAALSDGSVDAALIAGPAALKAMKSGSKLVANGEGLVDGI
                     IVTAVSTDFAEKHPEIVERFMKVEKETLEYVNNNFDEAMEKVAKEVDLSLEETKELYA
                     WYDFSLDITDKDISSLEDTQDFLIKNKLQEKKVNIKELIYNAK"
     gene            3652..4344
                     /locus_tag="KNP36_003024"
     CDS             3652..4344
                     /locus_tag="KNP36_003024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874875.1"
                     /translation="MSYKVYIVEDDISISTLLKDYIEKYGFEVIVEENFDDIMITFES
                     FKPHLVLLDVNLPKFDGFYWCRCIRQQSNLPIIFISARDGNVDQIRALESGADDYITK
                     PFYYDVVMAKIKSHIRRVYGEYSPKIDERIVELDGLKFYPERLELELNGENLIITKKE
                     GILIECLIKRYPKVVSRDYLLEKIWDDIEFVEENTLNVNVSRIRKRFEELGIDNAVQT
                     VRGLGYKLNKNW"
     gene            4354..5358
                     /locus_tag="KNP36_003025"
     CDS             4354..5358
                     /locus_tag="KNP36_003025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874876.1"
                     /translation="MKLFLKDYKGYIFIYYIGIVMTIIYCNLMKFISFGESLYILLFS
                     SFILLCFLIYKYYKNREVYNLFEKGVHSLEESFLYLGSSFLGRNISVILKQQHKLYQS
                     MIQEHKKIHSEHLTFINQWIHQMKTPISVISLQLQDYEGEEVTENIRKEIDRLNKGLD
                     MAMHFARADNFQKDFIVEKAKLNEIVSSIVNEEKRLFIKSGMIPKIQVDKFTYVYTDV
                     KWMKFIIGQLITNGVKYSKDYSNYLTIKSEENNKYVILSIIDEGIGIVSKDLKRVFDP
                     FFTGENGRKFGESTGMGLYLVKKVCDDLGHKVSIKSEVGKGTEVSIYFNKDVNSLIKV
                     "
     gene            5626..6477
                     /locus_tag="KNP36_003026"
     CDS             5626..6477
                     /locus_tag="KNP36_003026"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HBF0874877.1"
                     /translation="MSLDVIFILKSVIIAIVEGLTEFIPVSSTGHMILVGNLIDFKGQ
                     FAEMFEVVIQLGAILAVVVLYWKKIKDSVIEFFKFIFTGGKEGKIGFRFGMNVIIGCI
                     PFAIIGVLFYDNIKSLFNLQSVIIGFIVGGILLLVVETLFRKKNHSTDNIDKITPIQA
                     LKVGTLQVLSAWPGMSRSASTIMGGWIAGLNSPTAAEFSFFLAVPAMVASSGKDLFEF
                     DYSIMTPTLWIALVVGFIVAFIVSIIVMEKFVNFLKKKPMRVFAVYRIIMGVVLAVLA
                     FTNIISV"
     gene            6581..7327
                     /locus_tag="KNP36_003027"
     CDS             6581..7327
                     /locus_tag="KNP36_003027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001637630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874878.1"
                     /translation="MKILTVNNLSKVYGKKIIFNALNDINFSIEDGEFVGIMGPSGSG
                     KTTLLNMISTIDKPTTGTMELKGKNPLLLRGEELALLRRRELGFVFQDFNLLDTLTIG
                     ENIVLPLTLDKVSVKEQDERLNEVSTILGIKDLLGKRTFEVSGGQAQRTAIARALINN
                     PSILLADEPTGNLDSKSSKVVMELFQKINKENKVTTMMVTHDPLAASYCSRILFIKDG
                     SIYNEIYKGSSREQFYQEIMDVLTLLGGDN"
     gene            7327..9243
                     /locus_tag="KNP36_003028"
     CDS             7327..9243
                     /locus_tag="KNP36_003028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874879.1"
                     /translation="MNIKQFAINNISRNIKAYLGYLASIVISSSLLFSFIMFTSHPDL
                     DVSQFPDYLKEGLKMSKIIAYLFLFFFVFYSVSVFLKSRYKEFGILYITGISKRQVMK
                     LIFIENMIINIVSSVIGIIIGLIFAKIFLVIMSTFLELSPLKFYIPFNAILSTLIYFM
                     ILAVLTSIFTSFIVKENQVLKLLKGTKTPKPEPKTSLMLAILSICLFIIAYYNAITST
                     DQYTTYLRLVPVTSLTIVATYLFFSQFSVFFMKKLKLNKRFYRKNTNMLWISNLIYKV
                     KDNARIFFLITITSAVAFTAIGTVYSFWKDVERQINLIYPNTIYYSTMTLHNDPKKPD
                     SKEKDKERMMFIENNLKKENVDYTRTNGEFKTVFPKKSDFNVRIMKESKYLEITETIG
                     VKSISFEDNECISLLSSSLPGNNNVKENIIVGNRGLKVAKQVEECVMPAYYKNMYVVK
                     DNFYDSIESKFIVDRFTAFEVEDSSKTIEICREFENKFNNESGMQPYLFFSKELMIGT
                     GKLMYSTFIFLAIFIGLIFFVTTSSFLYNKFYMDCQVDKKKYEQLNKLGMTYNEIKKA
                     STIEIGIVFLFPYVVAVIHSIFALTALKNSFDIEVASSAVLVMGSLFLVQIVYFFIVR
                     NNYLKEIRLNLVNF"
     gene            9523..9756
                     /locus_tag="KNP36_003029"
     CDS             9523..9756
                     /locus_tag="KNP36_003029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /protein_id="HBF0874880.1"
                     /translation="MMILIQSRGKMKCKELSEELEVSERQIKSYKMYLEQAGIFINST
                     PGIYGGYEIDKCNSISLIKLLDSEVSIFISTKW"
     gene            9952..10380
                     /locus_tag="KNP36_003030"
     CDS             9952..10380
                     /locus_tag="KNP36_003030"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase"
                     /protein_id="HBF0874881.1"
                     /translation="MIKKLNSKDINKIMEIWEKSTIKAHDFISKEYWQNNYNTVKNEY
                     IPISDTFVYDDGDEIKGFISIIDKNFIGALFIKPKYQNLGIGGKLLDYATKKYKSLSL
                     AVYKDNKKAVVFYNKKGFNIVKEQVNEDSGFKEYIMEYSK"
     gene            complement(10834..11604)
                     /locus_tag="KNP36_003031"
     CDS             complement(10834..11604)
                     /locus_tag="KNP36_003031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874882.1"
                     /translation="MKVNENNIDEELDELSRKVYLESPDFWISISDKIIDKVFDEMLL
                     FFAVKYNYFNIVCFAIENNYLDLNMPSKNKKYTNIMEHLLDTSKQNEDKKIYNYLLSL
                     NKGNNLDERPILDELNCNISSDTFEKKDIYLPKYLCPSCNSNIFDTGYKVSNDITYKF
                     SSKEAEPIEMCSEVSSIRCCNCDELLEDITLDKLYNLCKIQNCNNCGSNLTKVGIIAK
                     KKMNFDENTEKFKDVSTFYCCGNCDSEISLSQREHFKI"
     gene            11928..12473
                     /locus_tag="KNP36_003032"
     CDS             11928..12473
                     /locus_tag="KNP36_003032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HBF0874883.1"
                     /translation="MKNTKVNIQDLTKMSICVALLCISSYIYIPLPFTPAGVTAQTIM
                     INLIALILTPRQAFSTVGVYIMIGLIGIPVFGGGTSGIGKLLSPTGGFYFGFLFAALI
                     ISLLKGRNNDIKRYILITIFVGMPIIYFMGTVFMCYFNQMTVEAALFAAVVPFLIGDT
                     IKSVIASFLGTKLNNVLRRNL"
     gene            12505..13641
                     /locus_tag="KNP36_003033"
     CDS             12505..13641
                     /locus_tag="KNP36_003033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiolase family protein"
                     /protein_id="HBF0874884.1"
                     /translation="MKEVFILGGLRSHIGLKNGIFQFVQPELLGASVLKDLIKKYEID
                     KIDEIICGNAVGTGGNIARLMTLTAGVSNEVPAFTVDMQCASAMMSIDIAFSKVKSGQ
                     CDLIIAGGFESSSLQPMRTYHKNDKRYNTNNPNYTVAQFSPDDNSQNSMLEGAERVAE
                     LYQIEKADLDFWVKESHKRAKEAREEKILEDIISPINNSTYDEGIRDKMSQRLLDRMP
                     SILGKETITNAANSCLINDGASFIIICSKKYLEHVKKKPKAKIINTCTIGTDATLSPT
                     SAIQAMDKLLEIESLNYLDVSAVEFNEAFAVIDVLFQRKYPELIDRYNIFGGALAYGH
                     PYGASGAIIALHLLKALEKTKGRYGICSIAAAGGLGSALLLERV"
     gene            13645..15036
                     /locus_tag="KNP36_003034"
     CDS             13645..15036
                     /locus_tag="KNP36_003034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding protein"
                     /protein_id="HBF0874885.1"
                     /translation="MNYYELLRIKKERHKNKNFLIIDGEKYTYENILSYSEELGKQIS
                     LGENIPILIYSKNIMFQLISFFAINYSKNIPIICHYNLSKKVLDDILLKNNISIIISD
                     ESMDVIDLYDDNNNEVAKKVNFSIFNPKFNIYMYQYKKLINYLDKSICMGALSSGSTS
                     VPKVLYRTYESWAGFFPIQNGIFNISGESILFVNGTLSFTGNLNSIMSVLYEGGSIVI
                     SSGLNCKSWIRTIKQYNVTNIYLIPTKLQLLVKHLKEPVLKVVSIFTGSQLLFEDTAR
                     NLKKYMPKSEIILYYGASELNYITYLCYDELIEKPLSVGRPFPGIDIYIREGKIFVNT
                     EYAVYNATKPYSVNDIGYYDNDGYLIFEGRSDDIINIGGFKVSSTKIENEVKKIPQIE
                     DAIVLPYSDTIRGNQIVLFVITIDKITKKDLLIKMKDNLMKNEIPKKIIFLNSFPYTS
                     SEKIDRLALLKML"
     gene            15112..15987
                     /gene="dpsA"
                     /locus_tag="KNP36_003035"
     CDS             15112..15987
                     /gene="dpsA"
                     /locus_tag="KNP36_003035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipicolinate synthase subunit DpsA"
                     /protein_id="HBF0874886.1"
                     /translation="MSNQYDITVIGGDLRQVYMVKKLINKGYSVVTYGISNEIINGIV
                     GKSTSLAEALSKSSIILCPIPFTKNQVNIENTDDCLDATIDNLLINLSPNQILFGGNI
                     PTKVCKFCEQHSIQIYDFMKMNDVAILNAVATAEGAIAEAIKRSIINIHQSNCLVLGY
                     GRCAQILAKKLYALDANVCVGARNNDARSTANAFGYSSISLSQLDEKLLQFDYIFNTI
                     PECILTKERLEKVSQEVTIIDIASSPGGVDYSVVKEAGINATLCLGLPGKYSPKTSGE
                     ILVNAIENIINERRD"
     gene            15990..16580
                     /locus_tag="KNP36_003036"
     CDS             15990..16580
                     /locus_tag="KNP36_003036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipicolinate synthase subunit B"
                     /protein_id="HBF0874887.1"
                     /translation="MRLEGLTIGVGFTGSFCTYDKIFIELENLVKEGANVHTIFSDVS
                     QNIDCRFGNSEEFMKKAYELTGNKPIVTIEEAEPFGPKGIADIIIIAPCTGNTAAKLA
                     NGITDSPVLMAAKGHLRNDKPLVISISTNDALSFNFKNIGILLNSKNIYFVPFGQDNC
                     KAKPNSMIAHTELIIPTIELALENKQLQPVIKSPHQ"
     gene            complement(16787..16987)
                     /locus_tag="KNP36_003037"
     CDS             complement(16787..16987)
                     /locus_tag="KNP36_003037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874888.1"
                     /translation="MEKLKTISVFSLIISVILTIGGIGIVTYYVDNLFIRGLSVFVLI
                     MSSSFVSTTVRLIFEESKRYKF"
BASE COUNT         6638 a         1754 c         2822 g         5825 t
ORIGIN      
        1 taagtgctca tttaaactat taattgataa taatattcaa tattaaataa taggaggcgt
       61 tatgaataaa tatcttctaa taaatccagt ggcagaaaga atgtatggag aaaagtttca
      121 ccttattaaa gcaaatttga taaaaaaggg gtacataata gcagaatgtg aaccacagtt
      181 agaatatgta aaaaagcagt acaaagagta tacaaaaaag actgaaaata caatgttgga
      241 ttgtagatgt ccagaaagta taagtctttt aaaaagaaat aatttgataa atgattttga
      301 agtacctatg atagaaccaa tattagtaag gacttgtagg gttttatacg ataaatatat
      361 aaaaagtaaa gatgatatgt tggtagtaac ctgtccatgt acacaattaa gagactttgc
      421 aagtgaaaag tttaaggata agggtaatgc tatgttttat acatggaaag agtttgctga
      481 acaagaaggt gtaaaatcac ttggaaaaat agatgaatca ccaattccat taggatattt
      541 caaagatact tttgaaaaag ttcttgaagt atcaagtgaa gacgaaatat taagtgaaat
      601 acaaaaaata agaaatggct ttgaagataa gtatgacata gtagaaatgt tttattgtaa
      661 agatggttgt aataatggag atggtttgta aatggtcaat aaatttaata ataagttttt
      721 aaggctagta aagagtgttt tgatattttt tataattctt ttattatgga aaattacaaa
      781 ttatcttggt atttggagtg attatatatt accatcacct gaaaaggtat atagtacatt
      841 tttaaatatg ataagtgatg gttcaatatt tattaatgta tatgcaagta tgaaaagagt
      901 tttgataggt tttgcaataa gtactgctat aggtgtgcct ttagggatat tctttggaat
      961 ttatagtgga gtatacgaat actttaaatc tctaataaat tttttaagga atacacctcc
     1021 ccttgcttta ataccaatgc ttatattatg gtttggtata ggagaggaat caaaaattat
     1081 aattatagtt ttagcatcct ttttcccaat ctttacaagc acattgaaag ggattaaaaa
     1141 ttgtgactca aaactgattg aagtgggtag agtatttgag ttttcaaagc ttcagataat
     1201 atttaaaata ataataccaa atgccattct tgatattgct gttgggttaa agttagctct
     1261 tggatatagc tttagagcca ttattggggc agaacttgta gcagcttcat ctggtcttgg
     1321 atacttgata tctgatggaa aagaaatgtc tagaacagat gttgttattg taggtataat
     1381 cgtaattgga cttttaggaa taattacaga ttacatattt tcgattattg tgaagaaggt
     1441 aagtaaggga aagatggtgg aagcatatga ataatttagt atgtgactct ggatatataa
     1501 ttagaaattt atataaaagt tataaagttg acaatgaaga acatgtagtt cttagtgata
     1561 tctctttaaa catagataga aaccatataa cagtaatttt aggtgaaagt ggttgtggaa
     1621 agactacctt gcttagagca attgcatcac ttgaaggtat aaatagtggt gaaattaggt
     1681 ttattaatga taataaagag tatagaccta atgttggttt tgtttttcag gagagcagat
     1741 taatgccttg gttaaacgta agtgaaaata tagcttttca taatcaaaga aaaaatacta
     1801 ttttaaacaa ggtgcttaga aaatttaaac acaataaaag aattagcagt aaaattataa
     1861 atgataattt tagaagctta gaaacaaatg ataatttgaa caaatcaaat aaatataata
     1921 ggaaaagtaa tattgatgta gaaaaatatc ttaagatgat gaacttgcag aaatttaaaa
     1981 actcttatcc aaatgaattg tcaggaggta tggcgcagag agtaagcata gctagagctc
     2041 tttctttcaa tccagatatg ttgcttatgg acgagccttt ttcggcatta gattatttta
     2101 caaggattga tatgcaaaat gaagttataa gaatacataa gtcaactaat aaaggcgtga
     2161 tatttgtaac tcatgatatt gatgaagcgt taaagatagg caagaaaata gttgttttca
     2221 cagacgaaag aaaagtaaaa gaatttaata tagaagatgg ttataataga gatttaactt
     2281 cagattacta tattaaatta aaaaaagata ttttaatgac aatgaaatca aataaaggca
     2341 tttaaagaaa ttaataatat tttaaggagt aaagtaaatg aaattaaaaa agctattgat
     2401 aggtataaca atattaacac ttgcaacagc atctttagct ggatgtgcta aaaaaaataa
     2461 tggagaaaaa ctttcagaaa taaatttaac ttatgtaaaa tcaccattaa atgttccttc
     2521 tataattcaa aaacaggatg atttatttgg aaaggaattt aaaaaggata atataaaagt
     2581 taatttctac gaaattacta caggtccaga gcaaacacaa gctttagctg ctggagaaat
     2641 agacttctta catgcactag gtggtacatc agctttaata gctgcatcta atggagtaga
     2701 gttaaagata ttaaacactt atagcaggtc accaaaagga tttatgattt tgactaataa
     2761 taattcaata aaatcagcag cagatttagt aggtaagaag gtggcaggcc caaaagggac
     2821 tatattacat caggtattga tttcagcact tgataaagaa ggattaagta tggatgatgt
     2881 ggaatttgtt aatatgggta ttccagaggc atcagcagct ctttctgatg gcagcgtaga
     2941 tgctgcattg attgctggtc cagcagctct taaagctatg aagtcaggta gtaaacttgt
     3001 agcaaatggt gaaggtttag tagatggtat aatagtaact gctgttagca cagactttgc
     3061 agagaaacat ccagaaatag ttgaaagatt tatgaaggtt gaaaaggaaa ctttagaata
     3121 tgtaaataat aattttgatg aagctatgga aaaagtagct aaagaagttg atttaagtct
     3181 tgaagaaact aaagaattat atgcttggta tgattttagt ttagatataa cagataaaga
     3241 catatcttcg cttgaagata cacaagactt cttaataaaa aataagttac aagagaaaaa
     3301 agtgaacata aaagaattaa tctataatgc taagtagaaa ctatgataaa ataatactaa
     3361 gtaagaaata tagtaaaagt ttaagttacc ttattaaggt aactttttct attttgaatt
     3421 agtaatttca atttatttta gaatgattag ttgataataa tgattaatta atcataaaaa
     3481 gatacttttt tatagagttt tattaagatg tctaataata tggttatact tatgaagtca
     3541 gtaattgtga agttagtaat atgattaaat ttatatattg taaaaagatt ataatatatt
     3601 aaaattggac tgttaatatg atgagtaaat aggtatatta ggaggaatta tatgagttat
     3661 aaagtatata ttgtggaaga tgatatatca ataagtacat tacttaaaga ttatattgag
     3721 aaatatggat ttgaagtgat tgttgaagaa aactttgatg atataatgat tacatttgaa
     3781 agttttaagc cacacttagt tctattagat gtaaatttac ctaaatttga tggtttctac
     3841 tggtgtagat gtattagaca acagtcgaat ttacctataa tttttatatc agctagagat
     3901 ggtaatgtag accaaattag agctttagaa agtggagcag atgattatat aacaaaacct
     3961 ttttactatg atgtagtaat ggcaaaaata aagagtcata taagaagggt atatggtgaa
     4021 tattcaccta aaatagacga aagaatagtg gagctagatg gattaaagtt ttatccagag
     4081 aggttagaac tagaattaaa tggtgagaat ctaattataa ctaaaaaaga aggtatactg
     4141 attgaatgtc ttatcaagag atacccaaaa gtagtaagta gagattatct tttagaaaag
     4201 atatgggatg atattgagtt tgtagaggaa aatactttaa atgtaaatgt tagcaggata
     4261 aggaaaagat ttgaggaatt aggtatagat aatgctgttc agactgtccg agggttagga
     4321 tataaattaa ataagaattg gtaaggagaa agtatgaagt tatttttaaa agattataaa
     4381 ggttatattt ttatatatta tataggcata gttatgacaa ttatttactg taatcttatg
     4441 aagtttatta gttttggaga gagtttatat attcttttat ttagttcttt tatattgtta
     4501 tgttttttaa tatataagta ttataaaaat agagaagtat ataatctgtt tgaaaaagga
     4561 gtacattctt tggaggagtc atttttgtat ttaggaagct cattcttggg gagaaatata
     4621 tcagttattt taaaacaaca acataaattg tatcaatcaa tgatacaaga gcataaaaag
     4681 atacatagtg aacatttaac tttcatcaac caatggattc atcagatgaa aacaccaata
     4741 tcagttataa gccttcagct tcaagattat gagggagaag aagtaactga aaatataaga
     4801 aaagaaatag atagattaaa taaagggtta gatatggcta tgcattttgc aagggcagat
     4861 aattttcaga aagactttat agttgaaaaa gccaaattaa atgaaattgt atctagtatt
     4921 gtaaatgaag aaaaaaggtt atttataaaa agtggaatga ttcctaagat tcaagtagac
     4981 aaatttactt atgtttatac agatgtaaaa tggatgaaat ttataatagg tcaattaatt
     5041 acaaatggag tgaaatattc taaagattat agtaactacc taactataaa atctgaagaa
     5101 aataataaat atgtaatttt aagtataata gatgaaggaa ttggaattgt ttctaaagat
     5161 ttaaaaaggg tatttgaccc attttttaca ggagaaaatg gtcgtaagtt tggagaatct
     5221 acaggtatgg gtctttatct agtaaaaaag gtatgcgatg atttaggtca taaagtaagt
     5281 ataaaatcag aagtaggaaa aggtacagaa gtttcaatct actttaataa agatgtaaat
     5341 agtttaataa aggtgtaaat agtttgataa agatgtaaat tatctgttac aatagggttt
     5401 ttagttaatt gtactttttt attatacaat ttattaaatg aaatattcat agttaaataa
     5461 tcaaaattta agagcgttta tttgcaaacc ttacatagat gtaaggtttg tgtaatgttt
     5521 gcagatagtt aaattttcta atctaaatta caattaatat aagaaataac ataagagaaa
     5581 taacataaaa aaagaaattt tgtaaaaaag gaaggatgtt tattgatgag tttagatgtt
     5641 atttttatat tgaaatcagt cataatagct atagtagagg ggcttacaga atttattcca
     5701 gtttcatcta caggtcatat gattttggtt ggtaatttaa tagattttaa ggggcaattt
     5761 gctgaaatgt ttgaggttgt aatacaactt ggggctatat tagcagtagt agtactttat
     5821 tggaaaaaga taaaagatag cgttatagaa ttttttaaat ttatatttac tggtggaaaa
     5881 gaaggaaaga ttggttttag atttggaatg aatgtaatta taggttgtat accatttgcg
     5941 attataggag ttctatttta cgataatata aaatcattgt ttaatttaca atctgtaatt
     6001 ataggattta tagtgggtgg gattttatta ttagtagtag aaactttgtt tagaaaaaag
     6061 aatcattcca cagataatat agataaaatt actccaatac aagctttaaa ggttgggaca
     6121 ttacaagttt tgtctgcatg gccaggtatg tcaaggagtg catctactat tatgggtgga
     6181 tggatagcag gacttaattc tcctacagca gctgagtttt ctttcttttt agcagtacca
     6241 gctatggtgg cttcttcagg aaaagattta tttgaatttg attattcaat aatgacacca
     6301 acattgtgga ttgctttggt agttgggttt atagtagctt ttattgtatc aataatagtt
     6361 atggaaaaat tcgtgaattt tttaaagaaa aaaccaatga gagtgtttgc tgtatacaga
     6421 ataataatgg gtgtagtact tgcagtatta gcttttacta acataattag tgtatagaaa
     6481 aaatagattt atcatctata aaaattaaac taagataaat tataattaac aattatatat
     6541 atgttatttc aaaaattaaa ttaggaagga tagttaaata atgaaaattt taactgtaaa
     6601 taatttaagt aaagtatatg gtaaaaaaat aattttcaac gcattaaatg acataaattt
     6661 tagtatagaa gatggagaat ttgtaggaat tatgggtcca tctggtagtg gaaaaactac
     6721 tcttttaaat atgatttcta ctattgacaa gccaactaca ggaactatgg aattaaaggg
     6781 caagaatcct ttattgttaa gaggtgagga acttgcatta cttagaagaa gagagttagg
     6841 ttttgtattt caggatttta atttattgga tacattaact ataggagaaa atatagtatt
     6901 gccattgaca ttagataagg tcagtgtaaa agagcaagat gagagattga atgaagtatc
     6961 tacaatatta ggtataaaag atttattagg aaaaagaact tttgaagtat caggtggtca
     7021 agctcagagg actgctattg ctagagcatt gattaacaat ccatcaatac ttttagcaga
     7081 tgaaccaaca ggtaatttag attcaaagtc atcaaaggtt gtaatggagc tatttcaaaa
     7141 gataaataaa gaaaataaag ttactactat gatggtaact catgacccat tagcagcgag
     7201 ctactgtagt agaatcttat tcataaaaga tgggtctata tataatgaaa tatataaggg
     7261 tagtagtaga gagcagtttt atcaagagat aatggatgta cttacattat tgggaggcga
     7321 taactaatga atataaaaca gtttgctatt aacaatattt caagaaatat taaagcgtat
     7381 ttaggatact tagcaagtat tgttatatca tcttcactgc tattttcttt tattatgttt
     7441 acaagtcatc cagatttaga tgtatctcaa tttcctgatt atttaaaaga aggtctcaag
     7501 atgagtaaga taattgcata tctattctta ttcttctttg tgttttattc agttagtgtg
     7561 tttcttaaaa gtagatataa agaatttgga atactttata ttacaggtat atcaaagcgc
     7621 caagtaatga aattaatctt tatagaaaat atgataataa atatagtatc ttctgtaatt
     7681 ggaataataa taggcttaat ctttgcaaag atatttttag tgattatgtc tactttttta
     7741 gaattatcac cattaaaatt ctatatacca tttaatgcga tattgtctac tttaatctat
     7801 tttatgattt tagctgtatt aacatcaata tttacttctt ttatagttaa agaaaatcag
     7861 gtgttgaagt tacttaaagg tacaaaaact ccaaaaccag agcctaaaac atcactaatg
     7921 cttgctatat taagtatttg tttgtttata atagcgtatt ataatgctat tacctcaacc
     7981 gaccaatata caacatatct gcgcttagtt ccagttacat cccttactat agtagcaact
     8041 tacttgttct tttctcaatt tagtgtattt tttatgaaga agctaaaact aaacaagaga
     8101 ttttatagaa aaaatacaaa tatgctttgg atttcgaact tgatttataa ggtaaaggat
     8161 aatgctagaa tatttttctt gataactata acttctgcag tagcatttac tgctataggt
     8221 acagtttatt ccttttggaa agatgtagag cgtcaaatta atttaatata tcctaacaca
     8281 atatattatt caacaatgac attgcataat gaccctaaaa agcctgatag caaagaaaaa
     8341 gacaaggaaa gaatgatgtt tatagaaaat aatctaaaaa aagagaatgt agactataca
     8401 aggactaatg gtgaatttaa aactgtattt cccaagaaaa gtgattttaa tgtcagaatt
     8461 atgaaagaat ctaagtactt agaaattaca gaaactatag gggttaagtc tataagtttt
     8521 gaagataatg aatgtatatc attattatca tcaagtttac caggaaataa taacgtcaaa
     8581 gaaaatatta ttgtagggaa taggggttta aaggtggcaa aacaagtgga agaatgtgtt
     8641 atgccagcat attacaaaaa tatgtatgtg gtaaaggata atttttatga tagtatagaa
     8701 tcaaaattta tagtggatag atttactgca tttgaagtag aggattcaag taaaactata
     8761 gagatatgca gagaatttga aaataaattt aataatgagt cagggatgca accatatttg
     8821 tttttctcta aagaattaat gataggaact gggaaattaa tgtattctac atttatattt
     8881 ttagcaatat ttataggttt aattttcttt gttactacaa gtagtttttt atataataaa
     8941 ttttatatgg attgccaagt tgataagaaa aagtatgaac agttaaataa attgggtatg
     9001 acatataatg agattaaaaa agcttcaaca attgagattg gaatagtatt tttgtttcct
     9061 tatgtagtgg ctgttataca ttcaatattt gcacttactg cacttaaaaa ttcttttgat
     9121 atagaagtag catcatcagc tgttttggta atgggaagct tgttcttggt tcaaatagtt
     9181 tattttttta ttgtaagaaa taattattta aaagagataa ggttaaattt agtcaatttt
     9241 tagttactat tattaaatga taataaaaag ggtttaaaat taattaatat tactggaatt
     9301 atagatgttt attttttcag taatattttt tattgtatta actattaaaa ttttgtacaa
     9361 atataaaata taatatggta aatgtcaaaa ttataaaaaa attctactta tataaaatat
     9421 aaagaggtta tatgtacata tgtgtagaaa taaataataa aaatatcaat taatgttatt
     9481 aggggggggt tactcattag taaattagct aatacactta gaatgatgat attaattcaa
     9541 agcagaggca aaatgaaatg caaagaatta tcagaagagt tggaagtaag tgaaaggcaa
     9601 ataaaaagtt acaagatgta tttagagcaa gctggtatat ttataaattc aacacctggg
     9661 atttatggtg gttatgaaat agataaatgt aatagcatat cattaattaa attattagat
     9721 agtgaagttt caatttttat atcaactaag tggtagataa gtagaatatt agcaatatca
     9781 acgagtattt agaaacttat tttatattaa taaagcagta tataaaattg tagaatcaac
     9841 aatagcatat actaaaacat ccaccttata ttaactaaat catatctaaa taaaatacac
     9901 ttacctacaa acattataaa atcaatacaa aaatgaggtg aaacaaaatt tatgataaag
     9961 aaattaaaca gtaaagacat aaataaaatc atggaaatat gggaaaaaag tacaatcaaa
    10021 gcacatgact ttataagtaa agaatactgg caaaataact ataatactgt taaaaacgaa
    10081 tatataccta tatcagatac atttgtatat gatgatggag atgaaataaa aggatttata
    10141 agcataatag ataaaaactt tataggagct ttatttataa agcccaaata ccaaaatcta
    10201 ggtatcggag gtaaactttt agattatgca actaaaaaat ataaaagtct aagcttagca
    10261 gtatataaag ataataaaaa agcagttgtg ttttataata aaaaaggttt taatatagta
    10321 aaagaacaag taaatgaaga ttcaggattt aaagagtaca taatggaata tagtaaataa
    10381 tatgattaca ttctattaaa aggataatta atttattttc tagttgattt tttaagagta
    10441 atttttaaaa tagactatat gaagataaag atatttatta tagatgtaag ttaatcagaa
    10501 ttgatatagc tacaaaagag gaaaataaaa ttgtatggtg tatttcagat ttaacaaatt
    10561 tactatttaa agataataag tttgatataa tattaaagat actttcacct ataaactata
    10621 gagtattgaa agaattttaa ataattatgg aatgctaata aaggtttgtt aaaatttaat
    10681 aattattaga ttatagaaaa ttgccatgaa attagttcat caagaactag tttcatagca
    10741 attttaattc ttataagtgt atttattttt acagatttaa aaaacttata cagtatctaa
    10801 taatgtaatc ttattacttt agcctataaa tatttaaatc ttaaaatgtt ctctttgaga
    10861 taagcttatt tcagagtcac aatttccaca acagtaaaat gttgagacat ctttaaattt
    10921 ttcagtattc tcatcaaagt tcattttttt ctttgcaata attcctacct tagttaaatt
    10981 agaaccacaa ttattacagt tttgaatttt gcataggtta tatagtttat caagtgtaat
    11041 atcttctaat aattcatcac aattacaaca tctgatagaa gaaacttcac tacacatttc
    11101 aataggttca gcttctttag aagaaaattt atatgttatg tcatttgata ctttataacc
    11161 tgtatcaaat atattagaat tacaacttgg acataagtac tttggaagat atatatcttt
    11221 tttttcaaaa gtatcactac taatattaca gtttaattca tctaaaattg gtctttcatc
    11281 taggttatta cctttattta agcttagaag ataattataa atttttttat cttcattctg
    11341 ttttgatgta tctaacaaat gctccattat attagtgtat tttttgtttt ttgaaggcat
    11401 gtttaaatcc agataattgt tttcaatagc aaagcatact atattgaaat agttatattt
    11461 aactgcaaaa aataataaca tttcatcaaa tactttatct attattttgt cagaaatact
    11521 tatccaaaaa tctggtgact ctaagtaaac tttcctacta agttcatcta actcttcatc
    11581 tatattattt tcattaactt tcatatcatc acttcctttt aaatatcttg tgtataaact
    11641 atttgttact attttttata taaaataaaa tcttatataa aaatatatca tattataatt
    11701 tacaagtata gtctaaatag agctgttttt aagcaaagtt ttataaatga ctattaaaat
    11761 ataaagtaac agtataaagt ttacttataa attaaatgta aacctaaata attataatag
    11821 ttgacaaaaa aacgtcttta ttttatacta aaacaaagct ttaatagaag ctttgtatat
    11881 gtacatataa actaaatgaa ataagacata tgaagggaat tataaaaatg aaaaatacta
    11941 aagtaaatat tcaagattta actaaaatgt caatatgtgt agcattattg tgtatatcat
    12001 cttacatata tataccattg ccatttactc cagcaggagt aacagcacaa acaataatga
    12061 taaatttaat agctttgatt ttaacaccaa gacaagcatt tagtacagtt ggtgtatata
    12121 taatgatagg tttaattggg attccagtat ttggtggagg tacatctggt attggaaagt
    12181 tattaagccc aacaggtggt ttttattttg ggtttttgtt tgcagcacta attattagtt
    12241 tattaaaagg acgaaataat gatattaaga gatatatatt aataacaatt tttgttggaa
    12301 tgcctattat atattttatg ggaacagtat ttatgtgcta ttttaatcaa atgacagtag
    12361 aagcagcact ttttgcagca gtagtaccat ttttaattgg agatacaata aagtcagtta
    12421 ttgcatcttt tttaggcact aaactgaaca atgtactcag aagaaatcta tgataaatct
    12481 ataatataag gaagggtgta atgtatgaag gaagttttta tattaggagg attgagaagt
    12541 catataggtc taaaaaatgg aatttttcaa tttgttcaac ctgaattact aggagcaagt
    12601 gttttaaaag atttaattaa aaagtatgaa attgacaaaa ttgatgagat tatatgtgga
    12661 aatgcagttg ggacaggagg gaatatagct agattaatga ctttaacagc aggagtgtca
    12721 aatgaagtac ctgcttttac tgtggatatg cagtgtgctt ctgctatgat gagtatagac
    12781 atagcttttt caaaggttaa atctggtcag tgtgatttaa ttattgcagg tggttttgaa
    12841 agtagttctc tgcaaccaat gcgcacatat cataagaatg ataagcgata taatacaaat
    12901 aatccaaatt atacagttgc tcaattttct cctgatgata atagccaaaa tagtatgctc
    12961 gaaggtgcgg aaagagtagc agagttatat caaattgaga aagcagactt ggatttttgg
    13021 gtaaaggaaa gtcataaaag agcaaaagaa gcaagagagg aaaaaatact tgaagatatt
    13081 atatctccta taaataatag tacctatgat gaaggtatac gtgataagat gagtcaaagg
    13141 ttattagata ggatgccatc aattttagga aaagaaacta ttacaaatgc agcaaattca
    13201 tgtcttatta atgatggagc ttcatttatt ataatatgtt ctaagaagta tttagaacat
    13261 gtaaaaaaga agcctaaagc aaaaattatt aacacatgca cgataggaac agatgcaacc
    13321 ttaagtccaa catcagcgat acaagcaatg gataaacttt tagagataga aagccttaat
    13381 tatttagatg tatctgctgt tgaatttaat gaagcatttg cagttataga tgtgttgttt
    13441 caaagaaagt atccagagtt aatagataga tataatatat ttggtggagc tttagcgtat
    13501 ggacatccat atggtgcttc aggtgcaatt attgcattac atcttttaaa agcattagaa
    13561 aagactaagg gtagatatgg aatttgctct atagctgcag ctggtggtct aggttcagct
    13621 ttactgcttg aaagggtgta gattatgaac tattatgaac ttttaagaat aaaaaaagag
    13681 aggcataaaa ataaaaattt tttaattata gatggagaaa aatatactta tgaaaatata
    13741 ttgagttata gtgaggaact aggaaagcaa atttctttag gtgaaaatat cccaatttta
    13801 atatattcta aaaatataat gtttcagttg attagttttt ttgctattaa ttattcaaaa
    13861 aatattccta ttatttgtca ttataatctt tctaaaaaag tattagatga tattttatta
    13921 aaaaataata tttcaatcat tatatctgat gaatctatgg acgttattga tttatatgat
    13981 gataacaata atgaagtagc aaaaaaagtt aatttttcta tttttaatcc taaatttaat
    14041 atatatatgt atcaatataa gaagcttata aattatttag ataaaagtat ttgtatggga
    14101 gctttatctt caggttctac aagtgttcca aaggtattat atagaacata tgagagttgg
    14161 gctggatttt ttcctataca aaatggtatt tttaatatct ctggggaatc aatcttgttt
    14221 gttaatggaa cacttagttt tacagggaat ctaaattcta taatgtcagt attatatgaa
    14281 ggaggtagta ttgtaataag ttcaggtctt aattgtaaat catggataag gacaataaaa
    14341 caatataatg taactaacat ataccttata cctacaaaac ttcaactttt ggttaaacac
    14401 ttaaaagaac cagtactcaa agttgtaagt atttttacag ggtctcaatt attatttgaa
    14461 gatactgcaa gaaatctaaa aaaatatatg ccaaagtctg aaattatttt atactatggg
    14521 gcaagtgaat taaattatat tacatattta tgctatgatg aactaattga aaaacctcta
    14581 agtgtaggca gaccatttcc aggaatagat atatatatta gagaaggaaa aatttttgtg
    14641 aatacagaat atgcagtata taatgcaacc aaaccttatt ctgtcaatga tattggatat
    14701 tatgataatg atggatactt aatatttgaa ggaagaagtg atgacattat aaatattgga
    14761 ggatttaaag ttagttctac taagattgaa aatgaagtta aaaaaattcc tcaaattgaa
    14821 gatgcaattg tattgccgta ctcagacact ataagaggaa atcaaattgt attatttgta
    14881 ataactatag acaaaattac gaagaaagat ttgttgatta aaatgaaaga taatctaatg
    14941 aaaaatgaaa tcccaaagaa aattatcttt ttaaattcat ttccatatac ctcttctgaa
    15001 aagatagata gattagcatt attaaaaatg ttataagtat aatatttagt aattttagtg
    15061 aaccaatgta ttgataaaaa catattgtat atagtaaagg aggcttacaa tatgtcaaat
    15121 caatacgata taactgttat tgggggagac ctgcgacaag tgtacatggt aaaaaaacta
    15181 attaataaag ggtattctgt agtcacttat gggatatcaa atgaaattat aaatggaatc
    15241 gttggaaaat caacttcact agctgaagca ctatccaaaa gttccattat tttatgtcca
    15301 attccattta caaagaatca agttaatatt gaaaatacgg atgattgtct tgatgctact
    15361 attgataact tgctaattaa tttatctcct aatcaaatat tatttggagg taacatacca
    15421 actaaagttt gtaaattttg cgagcaacac tctattcaga tttatgattt tatgaaaatg
    15481 aatgatgttg ctattttaaa tgcagttgct acagctgaag gggctatagc agaagctatt
    15541 aaaagaagta taatcaatat acatcaaagt aactgtttag tattaggtta tggaagatgt
    15601 gcacaaatac ttgcaaaaaa attatacgct ttggatgcaa atgtatgtgt tggcgcaaga
    15661 aataatgatg caagaagtac ggctaatgca tttggatatt ccagtatttc tttaagtcaa
    15721 cttgatgaaa aacttttaca atttgattat atttttaaca ccataccaga gtgtatttta
    15781 acgaaagaaa ggttagaaaa agtatcacaa gaagtaacta ttatagatat agcttcttct
    15841 cctggaggag tagattattc tgttgttaaa gaagcaggga ttaatgcgac tctttgcctt
    15901 gggcttcctg gtaaatattc accaaagaca tctggtgaaa ttcttgttaa cgctatagaa
    15961 aatattataa atgaaagaag ggattagaaa tgagacttga aggacttaca attggagtag
    16021 gatttactgg ttcgttttgt acttatgata aaatatttat agagttagag aatttggtta
    16081 aagaaggagc taatgtacac actatatttt cagatgtatc acaaaatatc gattgtagat
    16141 ttggaaattc tgaagagttt atgaaaaaag catatgaact tacaggaaat aaacctatag
    16201 ttacgattga agaggcagag ccatttggac ctaaaggaat tgctgatatt ataataatag
    16261 ctccttgtac tggaaatact gctgcaaaat tagcaaatgg tattacagat tcaccagtat
    16321 taatggcagc aaaaggtcat cttcgtaatg ataaaccact agtaatatca atatcaacga
    16381 atgatgctct aagctttaat ttcaaaaata ttggcattct ccttaattct aaaaatatat
    16441 attttgtacc ttttggtcaa gataattgca aagcaaagcc taattctatg attgcacata
    16501 ctgagctaat aattccaact atagaacttg ctctagagaa caaacagcta cagcctgtta
    16561 taaaaagtcc acatcaatag aattggttct tataatatta tgtattagat acaatactag
    16621 caaagaggct gtctcaaaat agagagaagc ctctttttct tgttgaaatg atgaaaatat
    16681 atttaatttc atacaaaaaa atgcctcatg gactaaaaag tctattttga gctaatctcc
    16741 gtaatttttg ctatattaaa attatttact taatccaatt tttaaattag aatttatatc
    16801 gttttgactc ttcaaatatc aatctaactg ttgttgatac aaaagaagag gacataatta
    16861 aaacaaatac tgatagtcct ctaataaaca aattatctac ataataagtt actattccaa
    16921 tacctccaat cgttaaaatt acacttataa tcaaagaaaa aacgctaatt gtttttaatt
    16981 tttccatgct tatcctcctt cttataaact tcaaatttat ctatataata ttaaatata
//
LOCUS       DAEHWM010000095        16883 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.096, whole genome shotgun sequence.
ACCESSION   DAEHWM010000095 DAEHWM010000000
VERSION     DAEHWM010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16883)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16883)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16883
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.096"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            416..1819
                     /locus_tag="KNP36_003038"
     CDS             416..1819
                     /locus_tag="KNP36_003038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0874889.1"
                     /translation="MKMLNNFFKKINNPAPVFAQTKMERDNQTDDSLSTKPKTTFRDV
                     AGLDEVKEELFEIVDFMKSPQKYQKMGAKIPKGVLFYGPPGTGKTLLASAVAGETNSS
                     FFNVTGSEFVEKYVGVGAKRVRTLFEKARKEAPSIIFIDEIDAVGAKRHLESNNEKDQ
                     TLNQLLVEMDGFNKDSNVLIIGATNRLDLLDEALLRPGRFDRHIHIGAPNYHTRFEIL
                     KVHTDDKPIDKSVNLELLAKKTHGFNGAHLSNIANEAAIFAVRDDSECITSEHFDKAL
                     ERVIAGLESKNSALVEKEKKIVAYHEAGHALVSDIVGICPIQKISIVPRGQALGYVLQ
                     LPDEDRYIYTKDELIGKIKILLAGKASEELIFNHKSTGAKDDLKKVTEIANQMVCEYG
                     MSNLGFMTIDGNDKTFLCDKVQKEANRIVEICYKETLEMLKDNLEDLHSVSKFLFEKE
                     TMTHEELKDLIGKEAVN"
     gene            complement(2315..3337)
                     /locus_tag="KNP36_003039"
     CDS             complement(2315..3337)
                     /locus_tag="KNP36_003039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBF0874890.1"
                     /translation="MNQKKVHYNKSATSKDVARLAGVSQSSVSRAFGSANGKGVKPEV
                     RERIFRVANEIGYVPNLVARGMISGKTNVIGLIVGDSLGPFYNRIINLFVEKIQEIGK
                     QCLVFKVPRQQSIDSIISKVIQFQVEAVIITASAMNKVMAETCEENNIPVILFNRFIP
                     GIKISTVYVDPIEGGGMAAEYLLKKGHKNIGYIQFTRETSEEMEKKIGFYSKLRQSGI
                     HNLKEESANYDYDSGYEAGKRMLALSNPPTAIFCTSDLIAIGVMDAARFEYKLRVPED
                     LSVIGYDDIQMASWKSYNLTTIRQPLDLLIEKTINILKSLLNEENPESVVEMLKPELI
                     ERGSTL"
     gene            complement(3372..4970)
                     /locus_tag="KNP36_003040"
     CDS             complement(3372..4970)
                     /locus_tag="KNP36_003040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBF0874891.1"
                     /translation="MISSIDVCIIIGYLLLMLVIGYYSGKDNKNQEDYFLAGRSMPWI
                     PIALSVAATMISANGFIGGPGWAYVDGMYPVMVNITVPLAIFFALSITTPVIYKLKIT
                     SIYEYMGLRLGNYSRGLTIIQFFINSLIQASSMVYIPVLIIQMITGWSLYALVPIVVL
                     VSIIYTLLGGIKAVIWTDSIQMIVVISAVFIVIIVALKGMNLSFFDTLQIAQQSGKLN
                     TFDFSRDISVTNTFWATLIGGTVMWIRYFCFDQSQVQRVLTSKSLKCAKNSFVVSAFV
                     MNLVYYFMLLVGVILFVFYGGRTFETSNEIMITFILNELPVGAIGIIIAGVFAAAMSS
                     IDSILNSMTTVFTKDIYEFYFKKDNKESSLKVTMIITVVIGVVMTGFIIMGFGGSIKS
                     ILDLVGNYISYFAGPATGAFVLAMFTYKANDKGVSIGFIVGLVLGFFISNKYNVSWLW
                     NPAIGATITLIFGYIFSVILKKNHNADDIKKYTAFGMRNHLISQGMDKVDGVSIVPFS
                     LGKQELIVLAFFIIQYIILFLIQF"
     gene            complement(5012..6277)
                     /locus_tag="KNP36_003041"
     CDS             complement(5012..6277)
                     /locus_tag="KNP36_003041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0874892.1"
                     /translation="MKTTVEIENDIILGKDYSNLKRGIAFFSIALIYFFYCYNFMVGT
                     FIKPTMIYALADGGFGFSLKQTEEIFAVMSFGTIPGTFIFGVISTKIGKKRTLISVAL
                     LIGLTTFIPMLSPTNIMLWKIARLCTGVVLGGVFGTAMPLVADMFPSKYRGKLAAILT
                     ALFSLAMIFGGKVYGVLGDANWQILMYTAIIPPIVGAILAIFFVPDDLEYTKELVKKG
                     KETGEKISYISMYKGKYLWIGLGTILLSGANFTAYSAFSNNATTYLVTGIGMSAAVAE
                     SIYSLQGIGQLVGYLFWGSIADKFGRKIPFIGMALAAVFVFIYTKLGGDNTTTFYMIS
                     VLLGVAVGYSGAWGAYYTELFPSKYRSLSSGMSFNGGRIISTFAIPAIAGTASGTLGM
                     MTIFYISIAVFVAGAIVWLFLPETLNNKK"
     gene            complement(6419..7846)
                     /locus_tag="KNP36_003042"
     CDS             complement(6419..7846)
                     /locus_tag="KNP36_003042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ester cyclase"
                     /protein_id="HBF0874893.1"
                     /translation="MASTNKNNATSKEEEKEVSTSGLESCTVKENKAKMNQTNFSNIN
                     ENQTNENKTNTYKRNIDKGNIDKGNIDKTNTNKSDINKVNIDTVDTDKLNTNTLTEKN
                     KKVIFKGEDNMSSTKIYYGDSLEVTPVGVMDYNDFSKQTKREQEIPGFDSKYRDFVDY
                     IMKITHNIWEEKGIGVIYDTYHNNVTMHCGSSNLVGIKDVISNTLQTLHAFPDRRLIG
                     QNVIWSNFGADGFLSSHRVLSTATNLGDSNFGPATGRKINFRTVIDCATTNNRIHEEW
                     LVRDNLWIVTQLGLNPQEVAKSMAKASESKVLSLQSTYGICESMDGQFMPTKYQAKDD
                     SVGEMMLEMTSRIYNYKYINEVKKYYHDNAVVHFICDKDLNGYDEIQGMIVSLFASIP
                     NGSYEVERVTCNQREKNEGYDVSVRWRLRGINEGIGFFGQPSGKHIEVMGINHYHILQ
                     GKVKEEWITFDGMDVLKQIYMGVEE"
     gene            complement(7884..8891)
                     /locus_tag="KNP36_003043"
     CDS             complement(7884..8891)
                     /locus_tag="KNP36_003043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBF0874894.1"
                     /translation="MGKYQDSKKVVRNYFEALENATGDEVENVLKQHMKSDYNWKGVY
                     PFREQEGTENVADVFWKPLKKSLSNMQRRQDIFIAGTNEIDNSEWVMSMGHFMGLFDN
                     DWLGIKHTRKMISLRYAEFNCVQDGKIAKTGLFVDIIGFMIQAGVNPLPPQTGSYFVY
                     PGPIDHNGLLFEDADEVEGVKTLALVNKMVDDLSELNESGAMGCPPEILEKSWAKDMI
                     WYGPGGIGASYTIPRYQEQHQLPFRNNLKGKTFNGHVCRFAEGNFACFFGWPNLTNVP
                     CGGFLGLPGGEVKADMQVVDVYYRKGDKLQENWVLIDIPYWLKQQGLDILERTKSIFN
                     A"
     gene            complement(9088..10410)
                     /locus_tag="KNP36_003044"
     CDS             complement(9088..10410)
                     /locus_tag="KNP36_003044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874895.1"
                     /translation="MKILYVGPGMVIDKILAVSKKNFPNIEADFLRYDRYIEVPDLLE
                     KYRGRVDAVLFTGKSPFKFFEKRQKDFVLSDYIPRHETTLYRVLLEITYLLKFDISRL
                     SIDTYDKAMMKRLYKEIGVEFKDEHMFFAEQKYLEEDYIKFVLEFHKYNYQNNDVCCC
                     ITGLEEAYHIMKKDNIPVVLALPSEDVMVQSIKNIQMRYIAKKNNENQIIVLAIKLNM
                     PSEYSLMKEDEYAYLSQRIKILDKLYHFNSRIDGVLVEQSRSEFMIFTTKKILELETK
                     KYRDIYLLDMIREVSVINTYIGIGYGKTANEAKFNAYESIKMAQSQKNDAAYVVFENG
                     EIMGPLKPNPTVKEKNSFDERFYQIATETGLSANTVYKVFNKIINSGKTEFTSKELAT
                     ICGVSIRTMDRIILRLCDSGYCEVVSEQLMSKYGRPSRILRFKPFLLF"
     gene            complement(10768..12408)
                     /locus_tag="KNP36_003045"
     CDS             complement(10768..12408)
                     /locus_tag="KNP36_003045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacylase"
                     /protein_id="HBF0874896.1"
                     /translation="MFDVKIVNGIIVDGTGNSRYKSDVGIVGDKIMAIGDLSQKEAKE
                     TIDATGKFVSPGFIDFHTHSDLSLVYDKYTRSRIHTGVTTDVIANCGIGVAPIREEKK
                     QELIDYLGTRIIGTIPTKLELHWNTMQEYFDYLTENSPAVNVVAYVAQGPVRINEMGF
                     SKEPATLEQLKNMKLEVRKAMEAGCVALSSGLVYLPGAYTKKEEMAELCKELIPYNGY
                     YISHIRDEGDEEMEALDEAIYIAKTAGVPLHISHLKVMGHKNFGTIDEVFKKLDEAEA
                     DGLEVTFDCYPYTAGMTSLGALLPPWAFEGGVENMVKRLEVQENRDRIIKELEEGIPG
                     WQCFYQLAGGWNGVVLASVMTEANKYVEGKTLMEVAKINGENPFDTFFRLLIEEKSKI
                     QVVVHTQGQEDTDKVVCHPKSCIGSDSMDLSTEGLLSLGKPHPRAFGTFGRIFSYYVR
                     EKGMLTFEEAVKKITYLSAKRLGIYKERGLLKENYFADIVVFDPDTIEDKATYSNPKQ
                     YTVGVEYVLVNGKIALAGGKQTDVCAGRVIKNPLSIAK"
     gene            complement(12564..13220)
                     /locus_tag="KNP36_003046"
     CDS             complement(12564..13220)
                     /locus_tag="KNP36_003046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874897.1"
                     /translation="MYDKKMIKIGRISIGLAIIANFIPAIYVGIRFGQMPMLSVIFQI
                     WGLVAATYGVSWIVQPIAYYPTLGAPGSYIGWLAGSVGDIRMPAASMAQKIAGVEAGT
                     HEGEVVGTIGTCCSIFVSASMITIFTIVGYKVIPLLPEFVTNSFNYILPALFGAIYVD
                     IARKDIRAGGCTIAVALAIMYFGEKIGIPGGLLTLFIVLGGILITRVFFVIDNNKTKE
                     "
     gene            complement(13246..13947)
                     /locus_tag="KNP36_003047"
     CDS             complement(13246..13947)
                     /locus_tag="KNP36_003047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5058 family protein"
                     /protein_id="HBF0874898.1"
                     /translation="MKFQEMINSPGLWIVSSFLVIISVVQAIVFMKEALKEASNLGIE
                     KKGIKAAIRSASVTAIGPSLSPVITLLSLVAVIGAPTTWMRLCDVGAARTELGVISLT
                     SNLSGVEVGSAAFGAEAFSYALWGMALNNLGWLFVVFILGHRMRGIVEKMNMKYNPTW
                     VKKLLAGATVGLFAYLLSNQIKTFEIPKLTPAIISAIVMLVLTTLFKKNQRLQELSLG
                     IAMLIGMFGTQIILS"
     gene            14755..15234
                     /locus_tag="KNP36_003048"
     CDS             14755..15234
                     /locus_tag="KNP36_003048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0874899.1"
                     /translation="MDKTTFTNNILESEQTLYRVSKSILGNDQDCEDAVNNAILKAYE
                     KLDSLKEEQYFKTWLIRIVINECNSLRRKRLKSLSFEDVFKNKKIDEKDDYSDLYTAI
                     QSLPKKIKIPIVLYYIEGYSVDEVKEILDIPQGTVKSRLSRGRRLLKTKLENTEVII"
     gene            15231..16010
                     /locus_tag="KNP36_003049"
     CDS             15231..16010
                     /locus_tag="KNP36_003049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874900.1"
                     /translation="MNKNILNNSFPEVPESFHNSLSKTLNSLPEREENYKMINNKTHK
                     LPFRKGLVATLAITLILSTTALAVGHIYSLVGKSSTKATYTSIPTTEQVKKDFNFTPN
                     IVSEFSNGYKFKGAYTVNKKAFDKENNVLGKSKALSFEYKNGNDEISLDTANNVLGKS
                     SDNLKVVDTYKDINISYEAFAQKFIPEGYKMTEQDKIDEKSGKYTFSVGPNNESDKVE
                     VNEFKFLTWKQDGVYYSFTVQDSNLSMNDLVKMAHEVIDAK"
     gene            complement(16260..16760)
                     /locus_tag="KNP36_003050"
     CDS             complement(16260..16760)
                     /locus_tag="KNP36_003050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0874901.1"
                     /translation="MIEGIKFIKAEEKYIYSYWQTFDKIAKERKYLAMDEAFPFEETV
                     EFIKNIINKNLPQLFIIDLESDNCIGWCDVLPKTEKVGYLGMGILKEYREKGIGSSLL
                     KQIIDLSKEYGYEKIELDVFKSNSRAIHVYKSLGFVEVNTISSGFTWNDRPVKEEVIQ
                     MELTLI"
BASE COUNT         5880 a         3029 c         1993 g         5981 t
ORIGIN      
        1 ctactatact acacaacaaa tcctataatt atattctaat atactaccta ctactttgcg
       61 ctacaacaat ttctctattt atatgatttg taaaatatag tacaacattt tttatcattt
      121 tcatttcaac taaatttgta atattttatt caatacttaa taaatactta atcaatacat
      181 gctttataat actttactca atatataatc aatacataat ttataatttg taatacttta
      241 ttcaatacat aagtagaaat ctctatatac ataaattcat tttttcatac atcttacaaa
      301 tttattttta tttagataac atgtatattt tttccatgaa aaataaataa taaaaaatag
      361 taaatatgga aaatataaaa ttgattaaca ataattaatt acctgaggtg tgaatatgaa
      421 aatgctaaac aactttttta agaaaatcaa caatccagct cctgtctttg cacagacaaa
      481 aatggaaaga gataatcaaa cagatgattc actttctaca aaaccaaaga ctacatttag
      541 agacgttgct ggattagacg aagtaaaaga agaactattt gaaatagtcg attttatgaa
      601 gtcaccacaa aaatatcaaa aaatgggtgc aaaaatacct aaaggagtat tattttatgg
      661 tcctccagga acaggtaaaa ccctacttgc atctgctgta gctggtgaaa caaactcatc
      721 atttttcaat gttactggtt cagagttcgt tgaaaaatat gtaggtgtgg gagcaaaaag
      781 agttagaact ctatttgaaa aagctagaaa agaagctcca agtataatat ttatagacga
      841 aatagatgct gtaggagcaa agagacatct tgaaagtaac aacgaaaaag accaaacact
      901 aaaccaactt ttagttgaaa tggatggatt taataaagat tccaatgtat taataatagg
      961 tgctaccaat agacttgact tattagatga agctttactt agaccaggaa gatttgacag
     1021 acacattcat ataggtgcac caaactatca cactagattt gaaattctaa aggtacatac
     1081 agatgacaaa cctatagaca aatctgtaaa tctagaactt ttagctaaaa aaactcatgg
     1141 tttcaatggg gctcatcttt caaatatagc aaatgaagca gctatatttg cagttagaga
     1201 tgacagtgag tgtattacat cagaacattt tgacaaggca cttgaaagag ttattgcagg
     1261 gctagaatct aaaaactctg cattggttga aaaagagaaa aaaatagtag catatcatga
     1321 agctggacat gctcttgtaa gtgatatagt aggaatttgt cctatacaaa aaatatctat
     1381 agttcctaga ggacaagcat taggttatgt tcttcaatta cctgatgaag atagatatat
     1441 ttatactaag gatgagttga ttggaaaaat aaaaatatta cttgctggaa aggcttcaga
     1501 agaattaata tttaatcata aatctactgg tgcaaaggac gacttaaaga aagtcactga
     1561 aatagctaac caaatggttt gtgaatatgg tatgagtaac ttaggattta tgactattga
     1621 tggaaatgat aagactttct tatgtgataa ggttcaaaag gaagcaaatc gtatagttga
     1681 aatttgttat aaagagactt tagagatgtt aaaggataat cttgaagatt tacattctgt
     1741 ttctaaattc ttatttgaaa aagaaactat gactcatgaa gagttaaaag atttgatagg
     1801 aaaagaagct gtaaactaat atagttttaa aaatttgagg ctgtctcaaa atagagataa
     1861 gcctcttttt attgttaaag ttataaaaat acatttgatt ttatacaaaa aagtgcctca
     1921 taaactaaaa atttcatttt gagacactta catattttaa ttacatattt taattttgtc
     1981 tatttacaga atattatatc tacataaaac taaactgctg taaacttaac tacctccagt
     2041 aatgtttgaa gtggtataaa agctagtagc ctagtttcta cacttataat ttatatttta
     2101 cataactaaa tttagtagat ttttatactc acaatttaga acgattgaaa acttaaaaat
     2161 ttcttatcag atatctacaa cttaattagg tatctatcac ttgattaaat atctatcact
     2221 taattaggta tctatcactt gattaaatat ctgccattta attaaatatc taccacttaa
     2281 ttaaatatct accacttaat taaatatcta ccacttaaag tgtagaacct ctttcaatca
     2341 attcaggttt taacatttca acgactgact ctggattttc ttcatttaat aaggacttaa
     2401 gtatgttaat tgttttttca atcaacaaat ctagtggctg tctaatcgtc gttaaattat
     2461 aactcttcca tgaagccatt tgaatatcat catatcctat cactgataaa tcctctggca
     2521 ccctcaactt gtactcaaac cttgcagcat ccattacacc aatagctatc aagtcacttg
     2581 tgcaaaaaat tgctgttgga ggatttgata atgctaacat tctcttacct gcttcatatc
     2641 cagaatcata atcatagttt gcagattctt ctttaaggtt atgaatccca ctttgtctta
     2701 acttagagta aaatccaatt ttcttttcca tttcttcact tgtttctctc gtaaattgaa
     2761 tatatcctat attcttatga cctttcttaa gcagatattc agcagccatt cccccacctt
     2821 caattgggtc tacatagact gtacttattt ttataccagg tataaaacga ttaaaaagaa
     2881 tcacaggaat attgttttct tcacaagtct cagccatcac cttattcatg gccgaagctg
     2941 taataatcac agcttctact tgaaactgaa ttacttttga aattatacta tctatacttt
     3001 gttgtctagg aactttaaaa acgagacact gtttacctat ctcttgaatt ttttctacaa
     3061 ataaattgat aattctattg taaaatggac ctagactatc accaactatc aatcctataa
     3121 cattagtttt tccactaatc attccccgtg ctaccaaatt aggaacatat cctatttcat
     3181 ttgctacacg aaaaattctt tctcttactt caggttttac gccctttcca tttgcactac
     3241 caaatgctct tgaaacagat gattgagata ctcctgccaa tcttgcaaca tcttttgagg
     3301 tagccgattt attataatga actttctttt gattcattta gtatttctcc ttaaatatct
     3361 agtatttctt cttaaaattg tatcaaaaat aatataatat attggataat aaaaaaagct
     3421 aatacaatta attcttgttt acctaaagaa aatggcacta tagatactcc atctacttta
     3481 tccattcctt gagaaataag gtgatttctc ataccaaatg cagtgtattt tttaatatca
     3541 tctgcattat gatttttctt taaaatgaca ctaaaaatat atccaaatat caatgttatt
     3601 gtagcaccta ttgctggatt ccacaaccaa ctcacattat atttattaga aataaaaaat
     3661 cctaaaacta accctacaat aaaaccaata gatactcctt tatcattagc tttatatgta
     3721 aacattgcta gtacaaatgc acctgtagct ggtccagcaa agtatgagat atagttacca
     3781 acaaggtcaa gaattgattt gatgcttcct ccaaatccca taataataaa acctgtcata
     3841 acaactccta taactacagt tataatcatt gtaactttta atgatgattc tttgttatct
     3901 tttttgaaat aaaactcata aatatccttc gtaaaaacag ttgtcatact gtttaatata
     3961 gagtcgatac tagacattgc tgctgcaaac acacctgcaa taataattcc aatggctcct
     4021 actggaagtt catttaaaat aaaagtaatc attatttcat ttgaagtttc aaatgtcctt
     4081 cccccataaa aaacaaataa aattactcct accaatagca taaagtagta aactaaattc
     4141 ataacaaatg cactaactac aaaagaattt tttgcacatt ttaaagattt agatgttaaa
     4201 actctttgta cttgagattg gtcaaaacaa aagtatctta tccacattac agttccacca
     4261 attaaagtag cccaaaaagt atttgtcact gaaatatccc tactgaaatc aaatgtattt
     4321 aattttccac tctgttgtgc aatttgtaat gtatcaaaga aacttagatt cattcctttt
     4381 aaggctacaa taattactat aaatacagca cttattacta ctatcatttg aatactatca
     4441 gtccatataa ctgccttaat cccacctaat agagtgtata taattgatac aagtacaact
     4501 attgggacta aagcataaag tgaccagcca gtaatcattt gaataataag cactggaata
     4561 tataccatag aactagcttg aatcaatgaa ttaataaaaa attgaataat agttaatcct
     4621 cttgaataat ttcctaaacg aagtcccata tattcatata tagaggttat ttttaattta
     4681 tagataactg gggtggtaat gctcagtgca aaaaatattg ctaaaggtac tgtaatatta
     4741 accattactg gatacattcc atctacatat gcccatccag gaccacctat aaagccattt
     4801 gcactaatca tagtagctgc aactgataaa gcaattggaa tccatggcat tgacctacct
     4861 gccaagaaat aatcttcttg atttttatta tcttttcctg aataataacc aataactaac
     4921 attaatagca aatatcctat tataatacat acatcaattg atgaaatcat aagccacccc
     4981 tttctaagta acaaaataaa ttcctagtat tttatttttt attatttaac gtctctggta
     5041 agaataacca tacaatagca cctgctacaa agactgcgat tgatatgtaa aagatagtca
     5101 tcatacctaa agtaccagaa gctgtaccag ctatagcagg tattgcaaac gtagatataa
     5161 tccttcctcc attaaatgac ataccagatg acaacgaacg atatttactt gggaacaact
     5221 ctgtgtagta tgctccccat gctccagaat atccaacagc aacacctagt aatactgata
     5281 tcatatagaa tgttgttgta ttatctccac ctaattttgt atatataaaa acaaatactg
     5341 ctgctaatgc catacctata aaaggtattt ttcttccaaa tttatctgca attgaacccc
     5401 agaataaata tcctactaat tgaccaattc cttgtaaact atatatagac tcagccactg
     5461 ctgctgacat tcctattcct gtcactaggt atgtagttgc attatttgaa aatgctgaat
     5521 atgctgtaaa atttgcacct gataaaagaa tcgttcccaa tccaatccat aagtattttc
     5581 ccttatacat acttatatag ctaatctttt caccagtttc ttttcccttt ttaactaatt
     5641 cctttgtata ctccaaatca tctggcacaa agaagattgc taagatagct ccaactatag
     5701 gtggtataat cgcagtatac atcaatattt gccaatttgc atcacctaaa acgccatata
     5761 ctttcccacc aaaaatcatt gctaatgaaa ataaagcagt taatatagca gctaacttac
     5821 cacgatattt acttggaaac atatctgcaa ctaaaggcat agctgttcca aatacgcctc
     5881 ccaacactac tcctgtacac aaacgtgcta ttttccataa cataatattt gtaggagata
     5941 acattggtat aaatgttgtc aatccaatca gtaaagcaac gctaattaaa gtcctcttct
     6001 tcccaatttt tgtagaaatc accccaaaaa taaatgtacc tggaattgta ccaaaagaca
     6061 taactgcaaa tatttcttct gtttgtttta atgaaaaacc aaatccccca tctgctaaag
     6121 cataaatcat tgttggttta ataaaagtac ccaccataaa attgtagcaa taaaaaaagt
     6181 atattaaagc aattgaaaaa aatgcaattc ctctttttag gtttgaatag tcttttccta
     6241 atatgatatc attttctatt tcaaccgttg ttttcatatt tttataattc ccccttttaa
     6301 atttagtcat aattttgcta aaagtttaaa catctatttt tcatatacat tccccactta
     6361 aattttataa agcaatactt ccctatatat ttcaaaacta tttatactct aaacagcttt
     6421 attcttctac tcccatataa atttgtttta atacatccat accatcaaaa gttatccact
     6481 cctcctttac tttaccttgt agtatatgat aatgattgat tcccattact tctatatgct
     6541 ttccagaagg ctgtccaaaa aatcctatac cttcatttat tccacgtaat ctccatctta
     6601 cagatacatc ataaccttca tttttttctc tttgattaca agttactctt tccacttcat
     6661 aacttccatt tggaattgat gcaaataaac ttacaatcat tccttgaatc tcatcatagc
     6721 catttaaatc tttatcacat ataaaatgta ctactgcatt atcatgatag tattttttaa
     6781 cttcatttat atatttataa ttataaatac ggcttgtcat ttcaagcatc atttcgccaa
     6841 cagaatcatc ttttgcttga tacttagttg gcataaattg accatccata gattcacaga
     6901 taccataagt tgattgtaaa ctaagcactt tagattcact tgcctttgcc atactctttg
     6961 ctacttcctg agggtttaat cctaattgag taacaatcca taaattatct ctaaccaacc
     7021 attcttcatg gattctattg ttagttgtgg cacaatcaat tacagttcta aagtttattt
     7081 ttctacctgt tgctggtcca aaattactat cacctaagtt agttgctgta gacaaaacac
     7141 ggtgagaaga taaaaaacca tcagcaccaa agttagacca tattacattt tgaccaatta
     7201 atcttctatc aggaaacgca tgtaatgttt gaagagtatt ggaaataaca tctttaatac
     7261 caactaaatt tgaagagcca caatgcattg taacattatt gtgatatgta tcataaataa
     7321 cacctatacc tttttcttcc cagatattat gtgtaatctt cataatataa tctacaaaat
     7381 ctctatactt agaatcaaat ccaggtattt cctgttccct ttttgtctgt tttgaaaaat
     7441 cattgtaatc cattactcca acaggcgtta cttctaatga atctccatag taaatttttg
     7501 tagatgacat attatcttcc cccttaaata taactttttt atttttttca gtaagagtat
     7561 ttgtatttaa tttatctgta tccactgtat ctatgttaac tttatttatg tcggatttat
     7621 ttgtgtttgt tttatctata ttccctttat ctatatttcc tttatctata tttcttttat
     7681 atgtgttcgt tttattctca tttgtttgat tttcatttat attactaaaa ttagtttgat
     7741 tcattttagc tttgttttct ttaaccgtac atgattcaag cccacttgta gaaacttctt
     7801 tttcttcctc tttacttgtt gcattatttt tgttggtaga tgccacttta tatccccctt
     7861 tgttttagaa tacgtatgca taactaagca ttaaaaatac ttttagttct ctcaagaata
     7921 tcaagccctt gttgtttcaa ccaataagga atatcaatta acacccagtt ttcttgaagt
     7981 ttatcgccct tacgataata aacatcaaca acttgcatat ctgctttaac ctctccacct
     8041 ggtaatccta aaaaacctcc acatggtaca ttagtcagat taggccatcc aaagaaacaa
     8101 gcaaaattac cttctgcaaa tctacataca tgcccattaa aagtctttcc ttttaaatta
     8161 tttctaaatg gtagctggtg ttgctcttga tatctaggta tagtataaga agcaccaatt
     8221 ccacctggac cataccaaat catatcttta gcccaagatt tttcaagtat ttctggtggg
     8281 catcccatag caccactttc atttagttca gataaatcat ctaccatttt atttactaat
     8341 gctaaagttt ttactccttc aacttcatct gcatcttcaa aaagtaatcc attatggtca
     8401 attggccctg gatatacaaa atatgaacct gtttgtggtg gcaatggatt aactcctgct
     8461 tgaatcataa acccaattat atctacaaat aatccagttt tagcaatttt accatcttga
     8521 acacagttaa attctgcata tcttaaacta atcattttac gagtatgttt aatgccaagc
     8581 caatcgttat caaaaagtcc cataaaatgc cccatactca ttacccattc actattgtca
     8641 atctcatttg ttcctgcaat gaaaatatct tgtcgtcttt gcatattact caatgatttt
     8701 tttaaaggct tccaaaatac atctgctaca ttttcagtgc cttcttgttc acgaaatgga
     8761 tacacacctt tccagttata atctgatttc atatgttgct ttaagacatt ttcaacctca
     8821 tccccagtag cattttctaa tgcttcaaaa taatttctta caactttttt tgaatcctga
     8881 tattttccca taattatctc ctcccagatt tatttaagtt ataaattaac tttctcattt
     8941 catgcatacg atttcctttt taatgatttt ttagctgttt taagtttatt ttatgaatac
     9001 atatgcattt ttctaaatat taacatatat ctaaaaaatt gtaaagaaaa tgttatcata
     9061 aaaatttaat ttttgactta tatctattta aaacaacaga aaaggtttaa aacgtaatat
     9121 tctactgggt ctaccatact tgctcataag ctgttcactc actacctcac aataaccaga
     9181 atcacacaat ctaagtataa tcctgtccat agttctaata cttacaccac atatagtagc
     9241 taattccttt gatgtaaatt cagtttttcc actatttatt attttattga atactttata
     9301 tacagtatta gcacttagcc ctgtctctgt agcaatttga taaaaacgtt catcaaaact
     9361 atttttctct ttgacagtag gatttggctt tagtggtccc ataatttctc cattttcaaa
     9421 aactacatat gctgcatcat ttttttgact ttgagccatc ttaatactct cataagcgtt
     9481 aaatttagct tcatttgctg tttttccata accaattcct atataagtgt ttataactga
     9541 aacttcacga atcatatcca acaaataaat atctctgtat ttctttgttt ctaactcaag
     9601 tattttttta gttgtaaaaa tcataaattc acttctactc tgctctacca aaacaccatc
     9661 tatacggcta ttgaaatggt atagtttatc aagaatctta atcctttgtg aaagataagc
     9721 gtactcatct tccttcatta gtgaatattc tgaaggcatg ttcagtttaa tagcaagaac
     9781 aataatctga ttctcattgt ttttctttgc aatataacgc atctgaatgt tttttatact
     9841 ttgcaccatt acgtcctcag aaggcaaggc taaaactact ggaatattat cttttttcat
     9901 tatatgatag gcctcttcaa gacctgtaat acaacaacat acatcattat tttgataatt
     9961 atatttatga aattcaagca caaactttat atagtcctct tctaaatact tttgctctgc
    10021 aaaaaacata tgttcatcct taaattcaac tccaatttct ttatacaatc tcttcatcat
    10081 agccttatca taagtatcta tactaagtct actaatatcg aatttaagca aatatgtaat
    10141 ttcaagcaac actctgtaca atgttgtttc atgtctagga atataatcag acaatacaaa
    10201 atctttttgt cttttttcaa aaaatttaaa tggcgactta cctgtaaaaa gaactgcatc
    10261 cactctacct ctatattttt ccaataaatc aggtacttca atatatctat catatctaag
    10321 aaaatctgct tcaatattag gaaaattctt tttacttact gctagtattt tatcgattac
    10381 catacctggt cctacataaa gtattttcat ttcgtctctc ctttcctaat gatactatta
    10441 tctcttaaaa cattttctaa acctaccatg actaaagcca caggactcct gattcataga
    10501 attttgaata atcaattata cctaatataa aaagttactt taagtttttt aattacgact
    10561 atctgttgaa acatttttgt atttaaattt ttgtatttaa atcttattca ttaatattaa
    10621 ttacatttta caattaatat attgtttttt ctacttaaag ttaaattctt tagaaaacac
    10681 aagtagagta atctttatta atttaacaaa aatagccttc cttaatattc aaagaaagac
    10741 tatttttata aaagttctta atgtattcta ttttgctatg ctaagaggat ttttaattac
    10801 acgtccagca catacatcag tttgctttcc tcctgccaat gcaattttac cattcaccaa
    10861 cacatattcc actcccactg tatactgttt aggattacta taagtcgctt tatcttctat
    10921 tgtatctggg tcaaatacca caatgtcagc aaaataattt tctttaagta gacccctttc
    10981 tttataaatg cctaagcgtt ttgctgaaag ataagttatc tttttaactg cttcctcaaa
    11041 agtcaacata cctttttctc taacatagta agagaaaatt cgtccaaaag taccaaatgc
    11101 acgaggatga ggctttccaa gagaaagtaa accttctgta gaaaggtcca tactatcaga
    11161 acctatacat gactttggat ggcaaacaac cttatctgta tcctcttgac cttgtgtatg
    11221 aacaactact tgaattttac ttttttcttc aatcaaaagc ctaaagaacg tatcaaatgg
    11281 attttcacca ttgattttgg ctacctccat taaagtttta ccctctacat atttatttgc
    11341 ttcagtcatt acagaggcta gtacaacacc gttccaccca cctgctaatt ggtagaaaca
    11401 ttgccatcca ggaatccctt cctccaactc ttttataatt ctgtctctat tttcttgtac
    11461 ttctaatcgt tttaccatat tttctacacc gccttcaaaa gcccaaggag gtaaaagtgc
    11521 acccaaagat gtcattccag ctgtatatgg gtaacaatca aaagttactt ccaaaccatc
    11581 tgcctcagct tcatctagct ttttaaatac ctcatcaata gttccaaaat tcttatgacc
    11641 cataactttt aaatgagaaa tatgtagagg aactcctgca gtcttagcta tataaattgc
    11701 ttcatcaaga gcttccattt cttcatcacc ttcatctcta atatgagata tatagtatcc
    11761 attgtatggt atcaattcct tacataattc agccatttct tctttctttg tgtatgctcc
    11821 tggtaaataa actaatcctg atgaaagagc tacacatcca gcttccatag cttttctaac
    11881 ttccaacttc atatttttaa gttgctctaa agtagctggt tcctttgaaa atcccatttc
    11941 attgatacgt acaggtcctt gtgctacata agctacaaca ttgactgctg gagaattttc
    12001 agttaagtaa tcaaagtatt cttgcattgt attccaatga agctctaatt ttgttggaat
    12061 tgtaccaatt atcctagttc caagataatc aattaactct tgcttcttct cttctcttat
    12121 cggagcaact cctataccac agtttgcaat aacatctgtt gttacacctg tatggatacg
    12181 gcttcttgtg tatttatcat acacaagaga taaatcagaa tgagtatgga aatctataaa
    12241 accaggtgat acaaattttc cagttgcgtc tatagtctct ttagcctctt tttgacttaa
    12301 atctccaata gccatgattt tgtctcctac aatccctaca tcacttttat atcttgaatt
    12361 tcctgtacca tcaacgatta ttccattgac aattttaaca tcaaacatgc tttttctcct
    12421 ttcaagactt atttatattc atatttctta ataaacaatc ctattctttt ttctcaacaa
    12481 ataattctag tctttctcct taataaacaa tcctattctt tttctcaaca aataattcta
    12541 gtctttctcc ttaataagca atcctattct tttgttttat tgttatcaat tacaaagaag
    12601 acccttgtga taagtatccc acctaacaca ataaacaatg ttaataatcc acctggtata
    12661 ccaatttttt caccaaagta cataattgct aacgctacag caatcgtaca tccaccagct
    12721 cgaatatcct tacgtgcaat atcaacataa attgctccaa ataatgctgg aagtatataa
    12781 ttaaatgaat tagtaacaaa ttcaggtaac aaaggaatta ctttatagcc tacaatggta
    12841 aaaatggtaa tcatagaagc tgatacaaag attgaacaac atgtaccaat tgttccaaca
    12901 acttcaccct catgagttcc tgcttctaca cctgcaattt tctgtgccat tgatgctgca
    12961 ggcatacgta tatctccaac agaacctgca agccaaccta tataagaacc tggagctcct
    13021 agtgtaggat aataagctat aggttgaaca atccaactaa ccccataagt cgcagcgact
    13081 aacccccaaa tttgaaatat aacagaaagc attggcatct gaccaaagcg aatacctaca
    13141 tagatagcgg gaataaagtt tgcaataatt gcaagaccta tagaaattct ccctattttt
    13201 atcatctttt tatcatacat aattatcacc tcttatccgt tttaatcacg ataatataat
    13261 ctgtgtacca aacataccaa ttaacatggc aatacctaag gataattctt gtaatcgttg
    13321 attcttttta aataaagttg tcaatactag cataactata gctgaaataa ttgctggtgt
    13381 aagttttggt atttcaaatg tttttatttg atttgaaaga aggtaagcaa ataatccaac
    13441 tgtagcacct gcaagtagtt ttttaaccca agtaggatta tacttcatgt tcatcttttc
    13501 aacaattcca cgcattctat gacccaaaat aaatacaaca aatagccaac ctaagttatt
    13561 taaagccatc ccccatagtg catacgaaaa agcttctgct ccaaatgcag cactacctac
    13621 ttctacccca gataaattgg atgtaagaga tattactcca agctctgttc tagctgctcc
    13681 gacatcacag agcctcatcc aagtcgtagg agcgccaatc acagctacca gtgataataa
    13741 tgtaataaca ggagatagag aaggtccaat ggctgtaaca ctagctgagc gaattgctgc
    13801 tttaattcct ttcttttcaa taccaagatt tgaagcctct tttagtgcct ctttcataaa
    13861 tacgattgct tgaacaactg aaataattac taaaaaacta gaaacaatcc aaagacctgg
    13921 gctattaatc atttcttgaa acttcatact ttattcctcc ttaaaataaa tttttcagca
    13981 ttttattgtg agctttcttt ctgtaatctt gttatgtttt tatattgttt taatttattt
    14041 tatctaagat atagtatctt taataggaga ttatctgtct taaagtctca ctaaaaacat
    14101 taatacttaa atattttatt cataattagt aaatatcaga aaattcacat attatttttt
    14161 taacctgtaa ttaacttata aggtctttta ttattttgac atttcaatat aaaaatttta
    14221 atcaaaaaac tttattattt taaaaaaaat tattattttt ataatttata ttttttaagt
    14281 ttatttatgt tcatctctat ctaaaataat gacatttcta actcttaatt ctcatttaag
    14341 tttcattgtt ttttcttaaa agcctacttt tagtcaagat actgttatct ttactcatta
    14401 tttaaagaac ttattttaaa tctgtacatg aagtaaataa tccaaaagca ttgttattct
    14461 aactactcaa cattaaatac ttactatttt ctaattactc aatataaaga cttactataa
    14521 aactaaatac ataaatggct tctaaagttt aatatatcta catggcttta tatatgacag
    14581 gaaaaatact agaaaaaata tattatagaa tacttgtata taataggcaa aactttcaaa
    14641 cttaaattta tcaaataatc ataaaaaaag tgaaccatct atagtaaaat tttatctaat
    14701 aagtgaaagg caaaaaagta gcgctacgat ttgcatagaa gggaaggaac ttagttggat
    14761 aaaactacat ttacaaacaa tatacttgaa tcagaacaga ctttgtatcg agtatctaag
    14821 tctattctag gaaatgacca agactgtgaa gatgccgtca acaatgctat tttaaaagca
    14881 tatgaaaagt tggattctct taaggaagaa caatacttta aaacatggct gattagaata
    14941 gtcataaatg aatgtaattc attaagacgc aaacgattaa aatctctatc atttgaagat
    15001 gtcttcaaaa acaaaaaaat tgatgaaaaa gatgactata gcgatttgta tactgctatt
    15061 caaagtctac ctaaaaaaat taaaattcca atagtccttt actatattga aggttattca
    15121 gtagatgaag ttaaggaaat attagatata cctcaaggaa ctgtaaaaag tagattatca
    15181 agaggaagaa gattattaaa aactaaatta gaaaacacag aggtaatcat atgaataaaa
    15241 atatattaaa taattcgttt ccagaagttc cagaaagttt tcataatagt ttaagcaaaa
    15301 cactaaatag tttaccagaa agagaggaaa attataaaat gattaataat aaaacacaca
    15361 aattaccatt tagaaaaggc ttagttgcaa ctttagccat tactttgata ttgagcacaa
    15421 cagcccttgc agtaggacat atatatagtt tagttggaaa atcaagtact aaggctacct
    15481 atacatctat cccaactaca gaacaagtaa aaaaagactt taactttacc cctaatatag
    15541 tttctgaatt tagtaatgga tataaattta aaggagcata tactgtaaat aaaaaagcat
    15601 ttgacaaaga aaataatgtt ttaggaaaat caaaagcact tagttttgaa tataaaaatg
    15661 gcaatgatga aatatctctt gacacagcaa ataatgtact tgggaagagt tctgacaatc
    15721 taaaagttgt agatacttac aaagatatta atatttctta tgaagcattc gcacaaaagt
    15781 ttataccaga aggttataaa atgacagaac aggataaaat tgatgaaaaa tcaggcaaat
    15841 acacatttag tgtggggcca aataatgaat cagacaaagt tgaagttaat gaatttaagt
    15901 ttttgacatg gaaacaagat ggagtttact attcttttac agttcaagac tcaaatttat
    15961 ctatgaatga cttagttaaa atggctcatg aagtaataga tgcaaaataa acataagtaa
    16021 taataagttg tttatgagtt tattatttat gactttaatt tttttattag taaacatggt
    16081 tgtatcttcc atctttatat tttctttaaa tttaatatat aaaattttag atatttagct
    16141 accttcaaaa gaagcattat taaaaagccc ttaaaaatat ttcttttata tggaatttta
    16201 agggctttaa ctttatttta tacaagtgta tatggaattt taaagacttt aactttattt
    16261 tatataagtg taagctccat ttgaattact tcttctttta caggtctatc attccatgta
    16321 aaaccactag atattgtatt tacctctaca aaccctaaag atttataaac atgaatagct
    16381 ctactattac ttttaaatac atcaagctca attttttcat acccatattc ttttgataaa
    16441 tcaataattt gttttaaaag actacttccg ataccttttt ccctatactc tttaagaata
    16501 cccatgccta aataaccaac tttttcagtt ttaggtaaaa cgtcacacca accaatacag
    16561 ttatctgatt ctaaatcaat tataaacagt tgtggtaagt ttttatttat aatatttttt
    16621 ataaattcaa ctgtttcttc aaaaggaaag gcttcatcca tagctagata tttcctctct
    16681 tttgctattt tatcaaaagt ttgccaatac gaataaatat acttttcttc tgcctttata
    16741 aattttatgc cttctatcaa cttaacattt ccccttttta atttttgatt gtagttaact
    16801 tattttatat gattctagtt tataatgcta tataaattac tatatattag cttaaaatat
    16861 ctttgtatat ttctataaaa tta
//
LOCUS       DAEHWM010000096        16365 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.097, whole genome shotgun sequence.
ACCESSION   DAEHWM010000096 DAEHWM010000000
VERSION     DAEHWM010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16365)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16365)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16365
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.097"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            188..2047
                     /locus_tag="KNP36_003051"
     CDS             188..2047
                     /locus_tag="KNP36_003051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0874902.1"
                     /translation="MKRFLRRIILVLFILLIFISFISIKLIHNVGDYGKLINYVGIVR
                     GASQRLTKLEMNHQPNDELIEYIDEILQELITGHGDYGLVITDCNEYNEDLLLLEKKW
                     EDLNIEIKKVRMKEQNNQLLSISEEFFSLANDTVFKIENFSKEKSNYLMTLIIIISII
                     GILACIILILQYSKKMVRLEKLNVDLKNIAYKDELTGVNTIEKFKLDANQNICIHKDK
                     KFAVFYIDFENFKYINDIFGYDYGDMILKRYANLMMNDIGKYEIFAREIADRFVALRC
                     YVDKEDLVVRQRDVDNELINITNEIKNKHSITVVSGICCIEDVNEKLSIDGLINRANF
                     AQKTVKNKPGTNYAFYNDSIRKKMIEENTIKSRIHEAIEKREFIVYLQPKVNLHSQKI
                     NCAEALVRWLTPDKGIISPAIFIPVLEKNFFIALVDKYVFEEVCKWIRKRLDENKPFV
                     QISVNVSRIQFYNTKFVETYSNIQNKYRIPKNTIEIEFTESVAFENQKHLLEIIHDLH
                     ENGFTCSLDDFGKGYSSLSVLKDLPFDVLKLDSMFFKASLDKDKEKIVIKNIVHMLKE
                     LNITTVAEGIECKEQVEFLRDIGCDLVQGFVFYKPMPILEFEKILDKEFVYNS"
     gene            complement(2339..2938)
                     /locus_tag="KNP36_003052"
     CDS             complement(2339..2938)
                     /locus_tag="KNP36_003052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBF0874903.1"
                     /translation="MAIELKKGQKINLTKKENSDLGEILVNLNWNQKVQKKGFFGSLR
                     SSNIDLDLGCLFEMKNGVKGAVQALGNAFGSLDNPPFAQLDGDDRTGSNTQGENLRIN
                     GNKIKDIKRILIYAFIYEGVANWSEADGIVTIKQKQDSDLVVKLDEHKNGYNMCSIAL
                     IENVNDETFSVEKVVKYFKGHREMDTEFHWGLKWVAGRK"
     gene            complement(3041..3838)
                     /locus_tag="KNP36_003053"
     CDS             complement(3041..3838)
                     /locus_tag="KNP36_003053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0874904.1"
                     /translation="MKFKKLLCLLLCLVLTLAVVGCSKAKDDKKIVVGATLVPGGELL
                     EELKPLIKEKGYTLEVKNFDDYILPNEALNNGEIDANLFQHEPYLKEAVKAKGYKIMA
                     GKKLYVCPAILYSYKIKSVDEFKKGDTIAISNNPSSCSKNLRYLESIGLLTLPKGDGL
                     VSPKDIIENPKGIQFKELDIAQIPSSLPDVTAAFIDTTYAVPAGLDAKKNGIYTAPIN
                     DEYANLLAFRTEDKDSEKIKVLQDVLTSDKARSLIEEKYKGIVIPTF"
     regulatory      complement(3951..4056)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            complement(4148..5134)
                     /locus_tag="KNP36_003054"
     CDS             complement(4148..5134)
                     /locus_tag="KNP36_003054"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HBF0874905.1"
                     /translation="MLLIYNEKTNPYFNLAMEEYLLKNFDEDLFILWRNEPSIIVGKN
                     QNTLSEINLEYIKEYSIPVVRRQSGGGAVFHDLGNINFTFIACNNNNFSDFRRFTQPI
                     IDLLKTLDVNAEFSGRNDLLIDGKKFSGNAQYNYKNKVMHHGTLLFSSEINDLSKALK
                     VKPIKFEGKGIKSVKSRVTNISEHLHSKMDILEFKDAIMDYLSKTNTDNTNYCLSEHD
                     IKQIEKLTKSKYETWDWNFGNSPKYTLSNELKYSGGNVEFNLNVDKGIITSIKFFGDF
                     FGKCDVAFVENKLIGIRHEENALRNTLDSIEINDYFLGADTDILVSGILGVK"
     gene            5618..7348
                     /locus_tag="KNP36_003055"
     CDS             5618..7348
                     /locus_tag="KNP36_003055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na+/H+ antiporter NhaC family protein"
                     /protein_id="HBF0874906.1"
                     /translation="MRNKKINIIFLTTIMFIMSTVMVFAEEDIDTIALANAEKFGILT
                     LIPPLVAIILAFITKNVIISLLIGILSGSFIIKASGINVFATFIQAFLDLVDRALVSL
                     ADPWNAGIILQVLSIGGVINLVAKMGGAKAIAEALAKRAKSAKGTQLITWFLGLLVFF
                     DDYANSLIVGPMMRPVADKMKISREKLAFIIDATAAPVAGLAIISTWIGLEVGLIHDA
                     FESISIDVDAFGIFLNTIPFRFYNILILAFIVISALLLKEFGPMRKAEIKSRSRKISI
                     DLDEGVEELDDLAPKNGVKLSVWNAIIPIGTLIIVALASFYYSGYTSIMGGDDKALIQ
                     LFTNSPYSFEAIKEAFSASDASRALFQSALVASLVAIIMAVVKKIFTISEAIDVWIDG
                     MKSLVITGVILILAWSLSSVIKELGTAKFLIHLLSGSLPPFLLPSLIFGLGAIISFAT
                     GTAYGTMGILMPLAIPLAYSLNPDMSYVIVSTSAVLTGAIFGDHCSPISDTTILSSMG
                     AGCNHIDHVNTQMPYAIFTAVITIVFGYIPAGLGLPIYIVLPVAIAAIFVGIQIIGKK
                     VDEAEIELVE"
     gene            7458..7538
                     /locus_tag="KNP36_003056"
     tRNA            7458..7538
                     /locus_tag="KNP36_003056"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:7492..7494,aa:Leu,seq:tag)
     gene            7873..8388
                     /locus_tag="KNP36_003057"
     CDS             7873..8388
                     /locus_tag="KNP36_003057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HXXEE domain-containing protein"
                     /protein_id="HBF0874907.1"
                     /translation="MEKYIWLFPLLFIFHDMEEIIGFGIWLKKNKSMLDKKYPFISKV
                     YENYSTEGMAFAVFEEFILCIIFCILTVITENQYVYLLWLGSFIAYTLHLVIHIGQSI
                     IIRKYIPSLITSIICLPISIWCISKSIYIVDCEMSTTILYSIIGIIIVALNLKFAQSL
                     IGKFTKWMSNI"
     regulatory      8880..8984
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            9194..11668
                     /gene="gcvPA"
                     /locus_tag="KNP36_003058"
     CDS             9194..11668
                     /gene="gcvPA"
                     /locus_tag="KNP36_003058"
                     /EC_number="1.4.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl-transferring glycine dehydrogenase
                     subunit GcvPA"
                     /protein_id="HBF0874908.1"
                     /translation="MNELKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRK
                     SAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISALKINDIIYTPMCYENGGVVDDLLI
                     YKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQK
                     ITDIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVG
                     GEDICPAGLGCRDTLRFEAALPLYGHEINEHISPIEGGLSIFVKTNKESFIGKSILSK
                     EKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGCASPTTGKILGMGIIDSE
                     YAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKKDNIILNKENKFSYIPATSEDKSKML
                     KVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENLSLEDLTCFLG
                     AGAYDHYIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANA
                     SMYDGATAAIEACIMAMNQTRKSKIVVSKTIHPETLSVLRTYLQYKDCEIVEIDFCNE
                     YGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIMSVDPISLG
                     VLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGK
                     IAYVLTLQTREQHVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAH
                     YTYNKLVQTGKYKPIFKGKFFKEFAVQGNLNIETINDKLLEENILGGYNLEYNYPELK
                     NSTLLCVTEKRSKEEIDKLVGIMEGL"
     gene            11668..13125
                     /gene="gcvPB"
                     /locus_tag="KNP36_003059"
     CDS             11668..13125
                     /gene="gcvPB"
                     /locus_tag="KNP36_003059"
                     /EC_number="1.4.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl-transferring glycine dehydrogenase
                     subunit GcvPB"
                     /protein_id="HBF0874909.1"
                     /translation="MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIENMIDQDMARQSE
                     LNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCTMKYNPKINEDMAALPNFTGMHP
                     YQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDH
                     KRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINALKEVLNDEVAALMLTNP
                     STLGLFEKNIKEIATLVHEAGGLLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFST
                     PHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSIGKIKNFYGNFGVLV
                     RAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEA
                     NIKTIDIAKRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEA
                     KEEPELLKTAPHNTLVKRVDDARAVKKPILTWSQR"
     gene            13548..15905
                     /locus_tag="KNP36_003060"
     CDS             13548..15905
                     /locus_tag="KNP36_003060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IC family P-type ATPase"
                     /protein_id="HBF0874910.1"
                     /translation="MDKVNLERYSCDINVGLNKNQLQSRIDDNLINAFDNGKTKTYKQ
                     IFKDNIFTLFNLINIVLVCLLVSVGSFKNTLFIFIAVINTIIGVIQEIRAKRLLDNLS
                     VIVSNKVSVIREKEKKEIDVQELVLDDIMILKTGNQICADSKVLNGKLEVNESLVTGE
                     SDIIIKNKGDFLYSGSFVVSGEAFVRVENIGKDNYANKIANDAKISKKHNSQLRNSLN
                     AILKIVGIIIIPLGIILFAKQHFGNGDSIATSVVGTVAAVNGMIPEGLTLLTSIALAV
                     GTIKLASHKTLVQELYCVETLARVDTLCLDKTGTITEGKMQVDDIVMLEEVDINEIMG
                     NICNSLKDDNATLNAIRDKYNVLDTYKAKNLIPFSSERKYSGVTFENKGTYLLGAFEF
                     IFKEKNKKLRIEVERYSKKGNRVIVLAHSDSYMEDNNIPEDIKPLAFILILDKIRDEA
                     KETLEFFYNEGVDIKIISGDNPITVSEVARKAGLKTASNFIDATTLKNDSDIYKAVDK
                     YSVFGRVSPQQKKQMILALKKQNHTVAMTGDGVNDVLALKEADCSIAMASGSDVTKNV
                     SNLVLLDSNFASMPKVVMEGRKVINNIQRASSLFLVKTIFSFFLSLLTLFFFSRQYPF
                     VPIQLSLIGAVTVGIPSFFLALEANKSRISGNFLLNILKNALPGALCVTVNVIIVYNI
                     VEYLGYSSSVFSTMCAILTGVCGLLILRQQCLPFNKERLFLIVSMTIAFVIGILFLGG
                     LFSFVALSRELILITMALAILMPIMIKVMLFVLDEILETIVPDLN"
     gene            complement(15991..16308)
                     /locus_tag="KNP36_003061"
     CDS             complement(15991..16308)
                     /locus_tag="KNP36_003061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine/purine nucleoside phosphorylase"
                     /protein_id="HBF0874911.1"
                     /translation="MSEFKNVTAVKKANVYFDGKVSSRVIILPNGERKTLGLMLPGEY
                     TFSTREEEIMEMLAGSMDVKLPGSNEFVTYKEGQKFNVPSDSSFDLKVNEVVDYCCSY
                     IAD"
BASE COUNT         6155 a         1917 c         2682 g         5611 t
ORIGIN      
        1 aagaacttat atattagaaa aaaatttttg tatatataaa ggactctaaa gatgaactat
       61 gtaaaacaag gtttatatat tctaattgta tagaaaaatt tattgtaaac gcatgtatat
      121 tattagaaaa aatagtttgg aggtattcaa taaacataaa aaacaatata ggggataaag
      181 gtgttttatg aagagatttt tgaggagaat tatcttagtt ttatttattt tgttgatttt
      241 tataagtttt atttctatta aattaattca taatgttgga gattatggaa aattgattaa
      301 ttatgttggg attgttcgtg gagctagcca acgtctaact aaactagaga tgaatcatca
      361 accaaatgat gaattaatag aatatattga tgaaatccta caggagttga ttacagggca
      421 tggagattat ggtttagtaa tcactgattg taatgaatac aatgaggact tacttttatt
      481 agaaaaaaag tgggaagatt taaatattga aattaaaaaa gtaagaatga aagaacagaa
      541 taaccagtta ttaagtataa gtgaagagtt tttttctctt gcaaatgata cagtgtttaa
      601 aatagaaaac ttttctaaag aaaaaagtaa ttacttaatg actttaataa taattatatc
      661 tattataggt atattagcat gtatcatatt gattttacaa tatagtaaaa aaatggttag
      721 actggaaaaa ttaaatgtag atttaaaaaa tattgcatat aaagatgaac taacaggagt
      781 aaatactata gaaaaattta aattggatgc aaatcaaaat atttgtatac ataaggataa
      841 gaaatttgct gtattctata ttgattttga aaactttaaa tacattaatg atatatttgg
      901 atatgattat ggtgacatga tactgaaaag atatgctaat cttatgatga atgacatagg
      961 gaaatatgaa atatttgcaa gagaaattgc agatagattt gttgcgttaa gatgctatgt
     1021 agataaggaa gatttagtgg taagacaacg agatgtagac aatgaactaa ttaatataac
     1081 aaatgaaatt aaaaataaac atagtattac tgttgttagt ggaatttgtt gtattgaaga
     1141 tgtaaatgaa aaattaagta tagatggttt aataaataga gcaaattttg cacaaaaaac
     1201 tgttaagaat aaaccaggta ctaattatgc tttttataat gacagtattc gtaaaaaaat
     1261 gattgaagaa aatactatca aaagtagaat acatgaagct attgaaaaaa gagaatttat
     1321 agtttattta cagcctaaag ttaatttaca tagtcaaaaa ataaattgtg cagaagcttt
     1381 agttcgttgg cttactccgg ataaaggtat tatatctcca gcaatattta ttccagtact
     1441 tgagaagaat ttttttattg ccttagtaga taagtatgtt tttgaggagg tttgtaaatg
     1501 gattagaaag aggttagatg aaaataaacc ttttgttcag atatcagtta atgtttcaag
     1561 aatacaattt tataacacta aatttgtaga aacttattcc aatatacaaa ataaatacag
     1621 gatacctaaa aatactatag aaattgaatt tacagagagt gttgcttttg agaatcaaaa
     1681 acatcttttg gaaattatac atgatttgca tgaaaatgga tttacttgtt ctttagatga
     1741 ttttggaaaa ggttattcgt ctttaagtgt tttaaaagat ttaccatttg atgttttaaa
     1801 gcttgattct atgtttttca aggctagttt agataaagat aaagagaaaa tagtaataaa
     1861 aaatattgta catatgttaa aagaacttaa tatcacaact gttgctgagg gcattgaatg
     1921 caaggaacaa gttgaatttc ttagggatat tgggtgtgat ttagttcagg gatttgtatt
     1981 ttataaacca atgccaatat tagaatttga aaaaatattg gataaagagt ttgtttataa
     2041 tagctaaaat gtactttata aaatatgaac taattaagta aaattatttt gtactgaata
     2101 aatttttact ttatttacag aataatgatt atttacagaa aagcgcgaaa agtgtattcc
     2161 tttaagtgtg ggatggatag cacaaataga ggagaaaaaa tattggccat ataagaatgc
     2221 ataataatat aaatatttaa aaggtcagca ttatataaaa attaaaaaga aaataaataa
     2281 tttttctata aaaaagagac tatgagaaaa tttactcata gtctcctaaa taatgtattt
     2341 attttcttcc tgcaacccat tttaatcccc aatgaaattc agtatccatt tctctatgac
     2401 ctttgaagta tttaactact ttttcaacac tgaatgtctc atcatttaca ttttctatca
     2461 atgctattga acacatatta tagccatttt tatgttcatc aagtttgaca actaagtctg
     2521 aatcttgttt ttgtttgatt gttacaattc catcagcttc agaccagtta gctacacctt
     2581 cgtatataaa agcataaata agtattcttt ttatatcttt tattttatta ccatttattc
     2641 ttaaattttc tccttgtgta ttacttcctg ttctgtcatc tccatctaat tgagcaaaag
     2701 gtggattgtc taaactacca aaggcatttc ctaatgcttg aacagcacct tttacaccat
     2761 ttttcatctc aaataggcaa cccaaatcta aatctatatt actgcttctt aaagagccaa
     2821 aaaaaccctt tttttgtact ttttgattcc aatttaaatt aactaaaatt tcacctaaat
     2881 cgctattttc cttttttgta aggtttattt tttgtccctt ttttaattct atagccatag
     2941 taatcttcct ccacaaacat agatttattt aaatggtagc acttaataag tcaatattca
     3001 acaagattag aataataata ttaaaattat actaaatata ctaaaaagta ggaatcacaa
     3061 tacctttgta tttttcttca attaagcttc ttgctttatc tgatgtaaga acatcttgta
     3121 gaactttaat cttttcactg tctttatctt cagttctaaa tgctaaaaga tttgcatact
     3181 cgtcatttat aggagctgta taaattccgt ttttcttggc atcaagacca gcaggtacag
     3241 cataagtagt atctataaat gcagcagtca catctggaag agaagatgga atttgagcaa
     3301 tatctaactc tttgaattgt attccctttg gattttctat tatgtcctta ggactaacta
     3361 atccatcccc tttaggtaac gttaaaagtc caatactttc aaggtatcta aggttcttag
     3421 aacaagaaga tgggttattg cttattgcaa ttgtatctcc ttttttaaat tcatcaacag
     3481 attttatctt ataagagtaa agtattgctg ggcatacata tagtttttta ccagccatta
     3541 ttttgtaacc tttggcctta acagcttctt ttagataagg ttcatgttga aatagatttg
     3601 catcaatttc accattattt aaagcttcgt ttggaagtat gtaatcatca aagtttttaa
     3661 cttctaaagt atatcctttt tctttaataa gtggttttaa ttcttctaat aactctcctc
     3721 ctggaactaa agtagcacca acaacaattt ttttatcatc tttagcttta gaacatccaa
     3781 ccacagctaa agttagtact agacataata acaaacataa taattttttg aatttcatat
     3841 aaattccctc ctgaatataa ttgattagtt aaaaataaaa taccattctt tatcacactg
     3901 caaaataaaa ataagcctga gtttaaactc aggctttaaa agctaattta gactcatctt
     3961 tcagtataat actgcaggat ttagcaccaa tgtatataaa aatatactgg ttgctgggtt
     4021 tcatagggcc agtcccttca ccactctgga taagaagtat caatttttaa ttatgttata
     4081 aatattatca tgatttttta cgtctgtaaa cataatttta taaatatttt aaaatcttta
     4141 atgtatttta tttaacacct aaaattccag aaactagaat atcagtatca gcacctaaga
     4201 aatagtcatt tatttcaata gaatccagag tatttctcaa agcattttct tcatgcctta
     4261 taccaataag tttattttct acaaatgcaa catcacattt tccaaaaaaa tctccaaaaa
     4321 attttatact agttattatg cctttatcaa catttaaatt aaactcaaca tttccaccag
     4381 aatattttaa ttcatttgaa agagtatatt ttggtgaatt accaaaattc caatcccaag
     4441 tttcgtattt tgatttagta agcttttcta tttgttttat atcatgctca ctcaaacaat
     4501 aattagtatt atcagtattt gttttagaaa gataatccat tatagcatct ttaaattcta
     4561 atatgtccat ttttgaatgt aaatgttcac ttatattggt tacacgagat tttacagatt
     4621 ttattccttt tccttcaaat tttataggtt taacctttaa tgcttttgag aggtcattta
     4681 tttcagatga aaataaaaga gtcccatgat gcattacttt gtttttgtag ttgtattgag
     4741 catttccaga aaatttcttg ccatctataa gaaggtcatt tcttccagaa aattcggcat
     4801 tgacatctag tgttttaagt aaatctatta tgggctgagt gaatcttctg aaatcactaa
     4861 aattattatt gttacaagct ataaatgtaa aatttatatt tcccaaatca tgaaatacag
     4921 ctccaccacc agactgtctc ctaacgacag gtatagaata ttcttttata tattctaaat
     4981 ttatttcaga aagtgtgttt tggttttttc caacaattat agaaggttca ttcctccata
     5041 aaataaataa gtcttcatca aaatttttta gaagatattc ttccattgct aaattaaaat
     5101 aagggtttgt tttttcatta taaattaata acattaaagt agttcctcca tagaattgat
     5161 aaaattttta ttatgaatac aattaatttt ataattcgac aataatataa aaactccttt
     5221 aaattagaaa ttttaaaaac taccttgcaa agtttaaata aataatatat actcaaaata
     5281 tgtttaataa aagtgaatag aagggtagag gcgcaataat ctatcagtac taataaggag
     5341 ttaagcacag agagttatta ggaaaggaga tattgccgaa gttttataat cgatgcttta
     5401 agattatatt gctgggggta catagaaaat atgtacaact gtcacaggtt tatttgtggt
     5461 gagctatcat ttaaggaatt atattatatt tatttttact attgttgata tattgtaatg
     5521 tttaagcctt gagtgtttac cactcaaggc ttttttagtt ttattgtaac ataataccct
     5581 gtacagttca caaaattaaa aggagaggga gatttatatg aggaacaaaa aaattaatat
     5641 tatttttctg acgacaatca tgttcataat gtcaacagta atggtttttg cagaagaaga
     5701 tatagacact attgcactag ccaatgcaga aaaatttggg attttaactt taataccacc
     5761 attagttgct ataatactcg catttataac taaaaacgta ataatttctt tacttatagg
     5821 tattctttct ggtagtttta taattaaagc tagtggtatt aatgtttttg cgacatttat
     5881 acaggcattt ttagatttag tagatagagc tttagtatct ttagcagacc cttggaatgc
     5941 ggggataata ctacaggttt tgtcaattgg aggagtaata aatcttgttg ctaaaatggg
     6001 aggagctaaa gctatagctg aagcacttgc taaaagagca aagtcagcaa aagggacaca
     6061 gcttataaca tggtttttgg ggcttttagt attctttgat gattatgcca attcactaat
     6121 agtaggtcct atgatgagac ctgttgcaga taaaatgaaa atatcgagag aaaagctagc
     6181 atttataata gatgccacag cagcaccagt tgctggttta gctataatat ctacatggat
     6241 aggtcttgag gttggtttaa tacatgatgc ttttgaaagt ataagtatag atgtagatgc
     6301 atttggtata tttttaaata caataccatt tagattttac aatatattaa tattagcttt
     6361 cattgtaata tcagcattat tattaaaaga atttggtcca atgagaaaag ctgagataaa
     6421 atctagaagt agaaaaatta gtatagacct tgatgaaggc gtagaagagt tggatgattt
     6481 agctccaaaa aatggagtaa aattgagtgt atggaatgct ataatcccaa taggaacatt
     6541 gataatagtt gcattagcat cattttatta tagtggatat acatctataa tgggaggaga
     6601 cgataaggct ctgatacaac tatttacaaa ttctccatat tcttttgaag caataaaaga
     6661 agcatttagt gcatctgatg catctagagc attattccag tctgcacttg ttgcaagttt
     6721 agttgctatt ataatggctg tagtaaaaaa gatttttaca atatcagaag caattgatgt
     6781 ttggatagat ggaatgaaaa gtttagtaat cactggtgta atattaatac ttgcatggtc
     6841 attaagttca gtaataaaag agttaggtac agctaaattt ttaatacacc tactatcagg
     6901 ttcactacca ccattcttat taccaagttt aatatttggt ttaggagcaa taatatcttt
     6961 tgctactgga acagcttatg gaacaatggg tatacttatg ccacttgcaa ttccattagc
     7021 atactcatta aatcctgata tgtcttatgt aatagtaagt actagtgcag ttttaacagg
     7081 tgcaatattt ggagaccatt gttctccaat ttcagataca acaatacttt cttcaatggg
     7141 agctggctgt aatcatatag accatgttaa cactcaaatg ccatatgcta tatttacagc
     7201 agtaatcact attgtatttg ggtatatacc agctggactt ggattgccaa tatatatagt
     7261 attaccagtg gcaatagctg ctatatttgt aggtattcaa ataattggta agaaagttga
     7321 tgaagcggaa atagaacttg tagaataaag atataaataa gtttcacctt ttattatcac
     7381 tattttgtta gtttttagat aattttaaaa agttattgaa aataatggcg aaatatagta
     7441 aaataaaaga gtgataagcg gatgtggcgg aattggcaga cgcactagac ttaggatcta
     7501 gcgccattgg cgtgggggtt cgactccctt catccgcact ttacagtact taattgtact
     7561 gaaaaaaact ggggttgctg gctttcggag tgggctatcc cgtttttatt tttttgtata
     7621 tataatagat tggcacttta gtataaggtg ctttttttat aggcaaaaac agtacattta
     7681 tttctgtttt attatcattc atctattaga atatacttta gttaagaatg tgttaataag
     7741 cagtgttcac attcttgata aaatgtggaa taatatgtat ttttactaag acggaaatga
     7801 aataattaaa ccattaaata atattataag atgatgaata agtagataaa tcaaattttg
     7861 taggaggata ttatggaaaa atatatatgg ttgtttccat tactttttat ttttcatgat
     7921 atggaagaga taataggttt tggaatatgg cttaaaaaaa ataaatcaat gcttgataag
     7981 aagtatccat ttatcagtaa agtttatgaa aattatagta ctgaaggcat ggcatttgct
     8041 gtgtttgaag aatttatttt atgcattatt ttctgtatac ttacagttat aacagagaat
     8101 cagtatgtat atctactatg gttaggtagt tttatagcat ataccttaca tttggtaatt
     8161 catatagggc agtcaatcat aataagaaaa tatatacctt cacttattac cagtatcata
     8221 tgcttaccaa taagcatttg gtgtataagt aagagtattt atatagttga ttgtgaaatg
     8281 agtacaacaa ttctgtacag tataattggc attataattg tagcattgaa tttaaagttt
     8341 gcacagtcgc tgattggaaa atttacaaag tggatgtcaa acatataaat tttagtttat
     8401 tggacagttc aaggaatcag aaattggaat tttatagtat taatatttta tggtattaat
     8461 ataatgtata aaattttata gcaatgtatt tcataagtat aaagtgacta gaattttaag
     8521 aaatatacaa attctataaa aactaaataa tttcaagtat attttaaaaa tcttattttt
     8581 cacaagttta aaattgtaaa cgatttcatc aagtctatga atatactttt aacatgttat
     8641 agtaaatctc aatataaatt tacatttggt tctttgtgtg ttattttaat aataaattaa
     8701 gtgaaaatgt tattttacat taatatataa tatctttgca taagagtgaa taatataaaa
     8761 gagaaataat tgataataaa aacttaacaa aaaaattaat acataaaaaa aaataaatat
     8821 aatgtgttga catttaattg aaatattcat acaataaaat tgaaaataaa tatttccaaa
     8881 tgagattagc gagagagtcc tttatacgaa aaggcgccga agaagaaatt taagaaatgc
     8941 caatttttag agaagctttc aggcaaaaat atcgctaatt gatgggactc tggagagact
     9001 taagttaaga tactataagt caccgaagaa gcaaaataat attaaattat taaatctttc
     9061 aggtatacaa acagggatat ataggctagg attattttcc atgctgatat atcttttttt
     9121 tatgaaaaag tacaggaaat aatatcaaag ttacttaaat acagtaggtc taattttcta
     9181 gggagggtta tatatgaatg aattgaaaag agtatctttg tacaatatac acaaagagct
     9241 tggagcaaaa cttgttgaat ttgctggttg ggaaatgcct ttagaatatg agggtataaa
     9301 taaagagcat gagaaggtca gaaaaagtgc aggtatattt gatgtatctc atatgggaga
     9361 ggtacagata aagggagcag agtcagaaaa atttatacaa aacctagtta caaatgatat
     9421 aagcgcatta aagataaatg atattatata tacacctatg tgttatgaaa atggtggagt
     9481 agttgatgat ttattaatat ataaatttgg tgaagaagat tatttattag taataaatgc
     9541 aggtaatata gataaagatg tagcatggat aataaaacaa agtgaaggat acaatgtaga
     9601 tataaaaaat atatctagtg aagtgagtca attagcaatt caaggaccta aagcagaaga
     9661 aattcttcaa aaaatcacag atatagactt aaactcaata aaattttata agtcaattcc
     9721 atcaacaaaa gtatgtggtt gtccttgttt agtttcaaga acaggatata ctggggaaga
     9781 tgggtttgag atatactgta aaaataaata tgtagaaata atttggaatg aagttctaaa
     9841 ggttggagga gaagatatat gtccagctgg tctaggttgt agggatactt tgagatttga
     9901 agcagctcta cctctatatg gacatgaaat aaatgaacac atatctccaa ttgaaggtgg
     9961 tttatctatc tttgtgaaaa caaataaaga atcatttatt ggcaaatcaa ttttatcaaa
    10021 agaaaaagaa agtggagcta aaagaaagtt agtaggattt gaaatgcaag gtaaaggaat
    10081 gcctagaaat ggatatgata taaggattgg tgataaaaca gttggatttg taacaacagg
    10141 atgtgcatct ccaacgacag gaaaaatttt aggtatggga attatagatt ctgaatatgc
    10201 aaaagtagga aatgaaatag gtatagcaat cagaaaaaaa gttgttcctg ctgtgatagt
    10261 taagaaacct ttttataaaa aacaatataa aaaagataat attatattaa acaaagaaaa
    10321 taaattttca tatatacctg ctacaagtga agataaatca aaaatgttaa aagtagttgg
    10381 attaaattca gttgatgaat tattttcaga tataccagaa gaagtaaaat taaaaagaga
    10441 tttaaatttg gaaattggaa aatctgaatt agaggtaagc aaaatagtaa aaagattgtc
    10501 agaagaaaat ttaagtttag aagacttgac ttgttttctt ggtgctggtg catatgacca
    10561 ttatatacca tcaattataa aacatataac ttcaagatct gaattttata cagcatatac
    10621 cccatatcaa gctgaaataa gtcagggaac tttacaagta gtttttgaat ttcaatctat
    10681 gattgcagaa attacaggta tggaaattgc aaatgcatca atgtatgatg gagcaactgc
    10741 tgcaatagaa gcatgtataa tggcaatgaa tcagactaga aaaagtaaaa tagtagtgtc
    10801 aaaaactatt catcctgaaa ctctgtcagt attaagaact tacttacaat ataaagattg
    10861 tgagatagta gaaattgact tttgtaatga atatgggact acagatatag aaaaattaaa
    10921 agcttctgta gacaaagata cagcatgtgt tcttatacaa actcctaatt tctttggaat
    10981 tattgaagaa atggaagaaa tagaaaagat aactcatgaa aataaggcta tgttaattat
    11041 gagtgtagac ccaatatcat taggagtttt aaaaacacca ggtgagatag gtgcagatat
    11101 tgttgttgga gaagctcaat cacttggaaa ccctcttaat tttggaggtc cttatgtagg
    11161 atttttagct agcaaatcta aatatactag aaaaatgcca ggaagaatag ttgggcaaag
    11221 tttagatgta gaaggtaaaa ttgcatatgt attaacttta caaactagag aacagcatgt
    11281 aagaagagaa aaagcaactt ctaatatatg ttcaaatcaa gctttaaatg ctcttgtagc
    11341 ttcaatatat atggctacta tgggtaaaga aggatttaaa gaggttggta tgcagtctat
    11401 gaaaaaagca cattatacct acaataaact tgtacaaact ggaaaatata agccaatatt
    11461 taaaggtaag tttttcaaag aatttgctgt acaaggaaat cttaatatag aaactataaa
    11521 tgataaactc ttagaagaaa atatattagg aggttataat ttagaataca attatccaga
    11581 attaaaaaat tcaactttgc tttgtgtgac tgagaaaaga agcaaagagg aaatagataa
    11641 gttagttgga ataatggagg gattataatg aaagaataca atagtttgtt gatagatata
    11701 tctaaaaaag gtaggaaagc atactcactt ccaaagttag atatagatga tataaaaata
    11761 gaaaatatga ttgaccaaga tatggcaaga caaagtgagt tgaatttgcc agaagttggt
    11821 gaattagaat tagttagaca ttatacatta ttatcaaata aaaactttgg agttgataca
    11881 ggtttttatc ctttgggttc ttgtactatg aaatataatc ctaaaataaa tgaagatatg
    11941 gcagcacttc caaactttac tggaatgcat ccataccaat cttcggatac agctcaaggt
    12001 tctctttctt tgatgtatga tttatcaaga agacttgcag aaattacagg tatggatgaa
    12061 gttacactac aaccttcagc aggttctcat ggtgagttta cagggcttat gattataaaa
    12121 gcatatcatg aaaatagagg tgaccataag agaaccaaag tgataattcc agattctgca
    12181 catggaacaa atccagcaag tgcagctatg gcaaactttg atgtgattca aatagcatct
    12241 gataaaaatg gagctgtaga cataaatgca ttaaaagagg ttttgaatga tgaagtagca
    12301 gctcttatgc ttactaatcc aagtactctt ggtttatttg aaaaaaatat aaaagaaata
    12361 gctactcttg tacatgaagc aggaggactt ttgtactatg atggtgcaaa catgaacgct
    12421 attatgggga taacaagacc tggagatatg gggtttgatg tggttcatct taatcttcat
    12481 aagacttttt caactcctca tggaggtgga ggtccaggag ctggtcctgt tggagttaaa
    12541 aaagaattag tacctttttt accaatacca gtaattgaaa gaaaagaaga taagtatgta
    12601 ctaaattatg atagagaaaa atctattggg aaaattaaaa atttctatgg taattttgga
    12661 gttcttgtaa gagcttacac atatatacta actatgggaa gggatggact taaagaggct
    12721 agtgaaatgg cagttttaaa tgctaattat ataaaggaaa gtataaaaga tgattatatt
    12781 ttgccaatag ataccttgtg taagcatgag tttgtattag gtggattgcc aagaggagag
    12841 gccaatataa aaactatcga tattgcaaaa agactactag attatggata ccatcctcca
    12901 acaatgtact ttcctcttat tataaatgag gcacttatga tagaacctac agaaagtgag
    12961 agtatagaga cattagatag ttttatagaa gctatgaaaa gtgttgctaa agaggcaaag
    13021 gaagaaccag aactattgaa aactgctcca cataatactt tggtcaaaag agtagatgat
    13081 gcaagggcag taaagaaacc tatactaaca tggtcacaaa gataaatagt taaaaagtag
    13141 agatttaaag tataaagaga attaaatttg taagaaaaag ctatctaact taatctagtt
    13201 tagatagctt ttttgtatat tagtatgtat ggtattttct atataaagtt ttaaattata
    13261 ttagtgctta tatagaatat tgatatgatg attatgtata gatattaata agaattgttg
    13321 aatttatctt gccttaactt tatttactct tttatattaa gaaaaactta actaaaatat
    13381 agcgaaattc ataaaaattt aggaaatctt aagaattata atatttaaat ctttagattt
    13441 atattttatt atataaacta tagaataata aaataaaaaa attgagaatt ttataatata
    13501 tttgtagatt tgagtataaa aaagtgctaa gttgaaagga gtaaaatatg gataaggtta
    13561 atttagaaag gtatagttgt gatataaatg ttggtttaaa taaaaatcaa cttcaaagta
    13621 gaatagatga taatttaatt aatgcatttg ataatggaaa aaccaaaaca tataaacaaa
    13681 tttttaaaga caatatattt acacttttta atctcataaa tattgtttta gtctgtttat
    13741 tagtttcagt tggttctttt aaaaatacct tatttatatt tattgctgta attaatacta
    13801 ttataggagt aatacaagag ataagagcta aaagattatt ggacaatcta tctgttatag
    13861 tttcaaataa ggtatctgtc ataagagaaa aagagaaaaa agagattgat gtacaagaat
    13921 tagtattaga tgatattatg attttaaaaa caggtaatca aatttgtgca gattcaaaag
    13981 ttttaaatgg aaaattagag gtaaatgagt ctttggttac aggtgaatct gatattatta
    14041 taaaaaataa aggcgatttt ttatattctg gaagttttgt agtttctgga gaagcttttg
    14101 taagagttga aaatatagga aaagataact atgcaaataa gatagctaat gatgcaaaga
    14161 tttctaaaaa acataattct caacttagaa attcattaaa tgcaatatta aaaattgtag
    14221 gtataataat aattccttta ggaattatat tgtttgcaaa acaacatttt ggaaatggag
    14281 attctatagc tacatctgta gtaggtacag tggcagctgt aaatggtatg ataccagagg
    14341 gattaacatt acttacgagc attgctctag ctgtaggaac tataaaactt gctagtcata
    14401 aaactttagt gcaagaactg tactgtgtag agactcttgc tagagttgat acactatgtc
    14461 ttgataagac aggtacaatt acagaaggta aaatgcaagt tgatgatata gtaatgttgg
    14521 aagaagtgga tattaatgaa ataatgggga atatatgtaa ttctctcaaa gatgataatg
    14581 caacactaaa tgcaataaga gataagtata atgttttaga tacgtataaa gctaagaatt
    14641 taataccatt ttcttcagaa agaaaataca gtggggttac ctttgaaaat aaaggtacat
    14701 atttattagg tgcatttgaa tttatattta aggaaaaaaa taaaaaactt aggatagaag
    14761 ttgaaagata ttctaaaaaa ggaaacagag taatagtttt agctcatagt gattcttata
    14821 tggaagataa taatattcct gaagatataa agccactagc ttttatattg atattggata
    14881 aaattagaga tgaagctaag gaaactttag aattttttta caatgaaggt gtagatataa
    14941 aaattatatc tggtgacaat cctataacag taagtgaggt agctagaaaa gcaggtctta
    15001 aaacagctag taattttatt gatgcaacaa cacttaaaaa tgatagtgat atatacaaag
    15061 cagttgataa atacagtgtt tttggaaggg taagcccaca acagaaaaaa caaatgattt
    15121 tagcattaaa aaaacaaaat catacagtag ctatgactgg agatggtgta aatgatgtgc
    15181 tagcacttaa agaagcggat tgtagcattg ccatggcatc tggaagtgat gttactaaga
    15241 atgtgtctaa tttagtctta ttagattcaa actttgcatc aatgccaaag gttgttatgg
    15301 agggaagaaa agtaattaat aacattcaaa gagcatcttc tttgttttta gtaaagacaa
    15361 ttttttcatt cttcttgtcg ttattaacat tattcttctt cagtagacag tatccatttg
    15421 ttcctataca attatcactc attggggctg taacagtggg tataccatca ttcttcttag
    15481 ctcttgaagc aaacaaaagt agaatttcag gaaatttttt actcaatata ttaaaaaatg
    15541 ctttaccagg agcactatgt gtgacagtaa atgtaattat tgtttacaat atagttgaat
    15601 atttaggtta tagttcaagt gtattttcca caatgtgtgc tatattaact ggtgtatgtg
    15661 gtcttttaat attaagacaa caatgtttgc catttaataa agaaagatta tttttaatag
    15721 taagtatgac tattgcattt gttattggga ttctattttt aggtggatta ttctcatttg
    15781 tagcattgag tagagaatta attctcataa ctatggcatt agcaatatta atgccaatta
    15841 tgataaaagt tatgttattt gtcttagatg agatattaga gacaattgtt ccagatttaa
    15901 attaatttta aaatgatata aataagagca gttttagttg aactgctctt tttagatgtg
    15961 tttaatttta tgtaagaata tgtattttta ttaatcagct atatatgagc aacagtagtc
    16021 aacaacttca ttaaccttta agtcaaaact tgaatcacta ggaacattaa atttttgccc
    16081 ttctttataa gttacaaact cattgcttcc aggcagtttt acatccatac ttccagcaag
    16141 catctccatt atttcttctt ctctagtaga aaaagtgtat tctcctggca acattaatcc
    16201 taaagttttt ctttctccat taggcagtat tattactctg ctacttacct taccatcaaa
    16261 ataaacgttt gccttcttta ctgcagtaac attcttaaat tcactcatta gataaaacct
    16321 ccaaaattat ttgtacatat atattatata aaaataatgt aaaaa
//
LOCUS       DAEHWM010000097        15978 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.099, whole genome shotgun sequence.
ACCESSION   DAEHWM010000097 DAEHWM010000000
VERSION     DAEHWM010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15978)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15978)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15978
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.099"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            248..397
                     /gene="rpmG"
                     /locus_tag="KNP36_003062"
     CDS             248..397
                     /gene="rpmG"
                     /locus_tag="KNP36_003062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004402360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HBF0874912.1"
                     /translation="MRVKVTLACTECKQRNYNTTKNKKNNPDRIELQKYCRFCKKHTT
                     HKETK"
     gene            423..644
                     /gene="secE"
                     /locus_tag="KNP36_003063"
     CDS             423..644
                     /gene="secE"
                     /locus_tag="KNP36_003063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HBF0874913.1"
                     /translation="MAAQKNDGAKTKKRFSLFGYLKETKQELKRVTWPTKKELFKNTS
                     IVLTVVISCTILVWGIDTILSGALALLLK"
     gene            664..1206
                     /gene="nusG"
                     /locus_tag="KNP36_003064"
     CDS             664..1206
                     /gene="nusG"
                     /locus_tag="KNP36_003064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination factor
                     NusG"
                     /protein_id="HBF0874914.1"
                     /translation="MSELQEASWYVVHTYSGHENKVKATIEKAVKTRGMEDCIRQVVV
                     PTEEVVETTKTGKEKTRQRKVYPSYVLVKMIITDESWYVVRNTKGVTGFVGPGSKPVP
                     LSEDEVKAMGIDTTDPKVVNSDIDFEIGDTVKVSQGPFSGQIGNIEEIDLENREVKVC
                     INAFGKRTLFVIELEGIEKI"
     gene            1245..1670
                     /gene="rplK"
                     /locus_tag="KNP36_003065"
     CDS             1245..1670
                     /gene="rplK"
                     /locus_tag="KNP36_003065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012158357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HBF0874915.1"
                     /translation="MAKKVIGQIKLQIPAGKATPAPPVGPALGQHGVNIMGFTKEFNA
                     KTADQAGMIIPVVITVYQDRSFSFITKTPPAAVLIKKALNLKSGSGEPNKKKVAKMTS
                     AQVREIAELKMPDLNAASVEAAMSMIAGTARSMGVVIED"
     gene            1741..2439
                     /gene="rplA"
                     /locus_tag="KNP36_003066"
     CDS             1741..2439
                     /gene="rplA"
                     /locus_tag="KNP36_003066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HBF0874916.1"
                     /translation="MAKKGKRYAGALQKVDRTKFYDASEALTLVSDIAGAKFDETVEA
                     HIKLGVDSRHADQQVRGAVVLPHGTGKTKRVLVFAKGEKAKEAEQAGADFVGAEELVQ
                     KIQGENWFDFDIVVATPDMMGVVGRLGRVLGPKGLMPNPKSGTVTFDVAKAIDEIKAG
                     KVEYRLDKTNIIHVPVGKVSFGGEKLTENFTALMDAIIKAKPAAAKGQYLRSITVASS
                     MGPGVKINPARTAE"
     misc_feature    2491..2619
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            2662..3168
                     /locus_tag="KNP36_003067"
     CDS             2662..3168
                     /locus_tag="KNP36_003067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HBF0874917.1"
                     /translation="MRKAIEIKSEVVSEIVEKLQKSSAAVVVDYKGLTVEEVTELRKQ
                     MREAGVDYKVYKNTLVRRAAKEVGIEQFNDELLVGTNAIAFGYDDPVAPARILKGFMD
                     SHPKMKLKMGIVEGAFYDESKIVEMANIPSREVLIAKLLGSLKAPVSNFAYLIDAIAK
                     KAEGQEEA"
     gene            3226..3591
                     /gene="rplL"
                     /locus_tag="KNP36_003068"
     CDS             3226..3591
                     /gene="rplL"
                     /locus_tag="KNP36_003068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HBF0874918.1"
                     /translation="MTIEQILEAIENMKVLELNELVKAAEEKFGVSASAPVMVAGAAA
                     GGPAAEEKTEFDVVLTDVGSSKVGVIKAVREITGLGLKEAKEVVDNAPKTVKEGASKE
                     EADQIKEKLEAAGAKVEVK"
     gene            3982..4770
                     /locus_tag="KNP36_003069"
     CDS             3982..4770
                     /locus_tag="KNP36_003069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HBF0874919.1"
                     /translation="MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAN
                     EVINKISAEGGCAKFVYFNAREEETFTSMIEEVVKKEGKIDILVNNFGSTNPSLDKDL
                     VTGDTDNFFDTVNTNLKSVYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCV
                     SKAAINSLTQNIATQYAKDNVRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIG
                     EPDDIAKAVLFYASDDSSFITGDLLEVAGGFGLPTPQFADNILG"
     gene            5241..8957
                     /gene="rpoB"
                     /locus_tag="KNP36_003070"
     CDS             5241..8957
                     /gene="rpoB"
                     /locus_tag="KNP36_003070"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HBF0874920.1"
                     /translation="MPHPVTIGKRTRMSFSKIKEIADVPNLIEIQVDSYEWFLKEGLK
                     EVFDDISPIEDYTGNLILEFVDYSLDDKPKYDIEECKERDATYCAPLKVKVRLINKET
                     GEIKEQEVFMGDFPLMTERGTFVINGAERVIVSQLVRSPGVYYAEERDKTGKRLISST
                     VIPNRGAWLEYETDSNDVISVRVDRTRKQPVTVLLRALGIGTDAEIIDLLGEDERLSA
                     TLEKDNTKTVEEGLVEIYKKLRPGEPPTVESASSLLNALFFDPKRYDLAKVGRYKFNK
                     KLALCYRIMNKISAEDIINPETGEVFVKAGEKISYDLAKAIQNAGINVVNLLMDDDKK
                     VRVIGNNFVDIKSHIDFDIDDLNIKEKVHYPTLKEILDGYSDEEEIKEAIKSRIKELI
                     PKHILLDDIIASISYEFNIFYNIGNIDDIDHLGNRRIRSVGELLQNQVRIGLSRMERV
                     IKERMTVQDMEAITPQALVNIRPVSAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSA
                     LGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLGTYAKINEFGFIESP
                     YRKFDKETSTVTDEIHYLTADEEDLFVRAQANEPLTEDGKFVNHRVVCRTVNGAVEMV
                     PESRVDYMDISPKQVVSVATAMIPFLENDDANRALMGANMQRQAVPLVRREAPIIGTG
                     IEYRAAKDSGAVVVARNSGIAERVTADEIIIKREDGNRDRYNLLKFKRSNSGTCINQT
                     PIINKGDQIIKGDVIADGPATDLGEVALGRNCLIAFMTWEGYNYEDAILINERLVKED
                     RLSTIHIEEYECEARDTKLGPEEITRDIPNVGDSAIKNLDDRGIIRIGAEVDSGDILV
                     GKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTRENGDDL
                     SPGVNELVRCYIAKKRKIKVGDKMAGRHGNKGVISRVLPEEDMPFMENGTPLDIILNP
                     QGIPSRMNIGQVLEVHLGLAAKTLGWYVATSVFDGANEYDIMDALEEAGYPRDGKLTL
                     YDGRTGESFDNRITVGYMYYLKLHHLVDEKLHARSTGPYSLVTQQPLGGKAQFGGQRF
                     GEMEVWALEAYGAAHILQEILTVKSDDVVGRVRTYEAIVKGENIPEPGIPESFKVLIK
                     ELQSLCLDVKVLTDEDQEIEVRESVDEDDTIGEFELDVVNHMGEVEESNIIEEIEDDF
                     AENAEDEDIENLEEFTEDDLFEEEIDFDSDDFDM"
     gene            8999..12484
                     /gene="rpoC"
                     /locus_tag="KNP36_003071"
     CDS             8999..12484
                     /gene="rpoC"
                     /locus_tag="KNP36_003071"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HBF0874921.1"
                     /translation="MFELNNFESIKIALASPEKIRQWSRGEVKKPETINYRTLKPEKD
                     GLFCERIFGPQKDWECHCGKYRRVRYKGVVCDRCGVEVTKSKVRRERMGHIELAAPMS
                     HIWYFKGIPSRMGLLLDMSPRSLEKILYFASYVVVDPGETGLNEKQLLTEKEYRTALE
                     KYGYTFTVGMGAEAVKTLLQNIDLEQQSKDLRAELKDSTGQKKVRTIRRLEVVEAFKK
                     SGNKPEWMILDAIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLELGA
                     PDIIVRNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGK
                     RVDYSGRSVIVVGPELKFYQCGLPKKMALELFKPFVMDKLVKEGYAHNIKSAKSIVEK
                     VKPEVWDVLEDVIKSHPVLLNRAPTLHRLGIQAFEPILVEGKAIKLHPLVCTAYNADF
                     DGDQMAVHVPLSVEAQAEARFLMLSVNNILAPKDGSPITTPSQDMVLGCYYLTIEAQD
                     GAKGTGMVFKDFNELLLAYYNKSVHLHALVKLKVTLEDGRSSLVESTVGRFIFNENIP
                     QDLGFVDRKENPFALEVDFLADKKSLGKIIDKCFRKHGNTETAELLDYIKALGFKYST
                     LGGITVAVDDMSVPEEKKVFIAEAEAKVDKYEKAYRRGLISDEERYEKVIETWTETTD
                     KVTDALMGGLDRLNNIYIMAHSGARGSKNQIRQLAGMRGLMANASGKTVEIPVKSNFR
                     EGLSVLEYFTSSHGARKGLADTAIRTAESGYLTRRLVDVSQDVIVREIDCGTEDTTEI
                     YAIKEGNEVIEEIYDRIVGRYTIDPILNPETGEVIVEADSMIQEDEAETIVALGIEKI
                     RIRTVLNCKTNHGVCSKCYGRNLATGKEVNIGEAVGIIAAQSIGEPGTQLTMRTFHTG
                     GVAGADITQGLPRVEELFEARKPKGLAVITEVSGRVEIDETGKRKEVNVIPEEGETQT
                     YVIPYGSRLKVKQGQMLEAGDPLTQGFINPHDIVRVNGVKGVQEYIVKEVQRVYRLQG
                     VDVNDKHIEVIVRQMLSKVKVEDPGDTDLLPGGYEDVLTFNECNKDAIDKGLRPAVAK
                     RVLLGITKASLATDSFLSAASFQETTRVLTEAAIKGKEDHLIGLKENVILGKLIPAGT
                     GMKKYRNIAVEKIED"
     gene            12773..13195
                     /gene="rpsL"
                     /locus_tag="KNP36_003072"
     CDS             12773..13195
                     /gene="rpsL"
                     /locus_tag="KNP36_003072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HBF0874922.1"
                     /translation="MPTINQLVRKSRKALEKKSTAPALQKGYNSLNKKVTDASAPQKR
                     GVCTSVKTVTPKKPNSALRKVARVRLTNGIEVSAYIPGEGHNLQEHSVVLIRGGRVKD
                     LPGVRYHILRGTLDTAGVDKRRQSRSKYGAKRPKEAKK"
     gene            13319..13789
                     /gene="rpsG"
                     /locus_tag="KNP36_003073"
     CDS             13319..13789
                     /gene="rpsG"
                     /locus_tag="KNP36_003073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HBF0874923.1"
                     /translation="MPRKGNIPKREVLPDPMYGSKVVTKLINNLMVDGKKGKSQRIVY
                     DAFAIVAEKTGEEALEVFNKAMDNIMPVLEVKARRVGGANYQVPIEVRPERRQTLGLR
                     WLVKYTRARGEKGMVEKLAKEIMDAANNTGASVKKKEDTHKMAEANKAFAHYRW"
     gene            13838..15904
                     /gene="fusA"
                     /locus_tag="KNP36_003074"
     CDS             13838..15904
                     /gene="fusA"
                     /locus_tag="KNP36_003074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HBF0874924.1"
                     /translation="MARKFPLERTRNIGIMAHIDAGKTTTTERILFYTGQTHKIGETH
                     EGASQMDWMEQEKERGITITSAATTASWKDHRINIIDTPGHVDFTVEVERSLRVLDGS
                     VAVFCAKGGVEPQSENVWRQAETYGVPRIAFVNKMDILGADFYNVVSMMKSRLNSNAV
                     PMQLPIGKEDSFIGIIDLLKMDAVIYKDDLGVEMEETDIPEDMKELAAEWREKLVESV
                     AETDEELMMKYLEGEELTIDELKVAIRKATIACEMNPVFCGTAYRNKGVQLVIDAVLD
                     YLPAPTDIPAIKGILADGEEAERHSSDEEPFSALAFKIMTDPFVGKLAFFRVYSGTLE
                     SGSYVLNATKNKRERIGRILQMHANTREEITKVYAGDIAAAVGLKDTTTGDTLCDPAN
                     PIILESMEFPEPVISVAIEPSSKAAQEKMGIALQKLAEEDPTFTVKTDQETGQTIISG
                     MGELHLEIIVDRLLREFKVEAKVGAPQVAYRETITQPVDVEYKYSKQSGGRGQYGHVK
                     IRVAPQEPGEGYKFTNKTVGGSVPKEYVGPVDMGIQGAMQSGIVAGYPVVDVAVELYD
                     GSYHEVDSSEMAFKMAGSMAFKDAMKKGNAVLLEPYFKVEVVTPEDYMGDVMGDLNSR
                     RGLIQGMEARSGAQVINAFVPLSEMFGYSTDLRSSTQGRATYTMIFDHYEQVPASVAK
                     KIAEGK"
BASE COUNT         6257 a         1989 c         3249 g         4483 t
ORIGIN      
        1 ctttactaaa ctgatggatt aaaaggaata acaaaaagag gggttatgct cctctttttt
       61 taacatagaa atacaaaaac attgacacag cataggattt tgtgataact tatacaaggt
      121 aatgattata ggaagttaat aatatcttga atactgtaga tttttaataa atacatattt
      181 taaagatatt atattcacat atattaacaa tatatattat tgtattacaa agttggaggt
      241 gtatcagatg agagttaaag taactttagc atgtacagag tgtaagcaaa gaaactacaa
      301 cactactaag aataagaaaa ataatccaga cagaatagaa ttacaaaaat attgtagatt
      361 ctgtaaaaag catacaactc ataaagaaac aaaatagttt tttataagga tgtgagtatg
      421 gaatggctgc ccaaaaaaat gacggtgcaa aaactaaaaa aaggtttagt ttgtttggat
      481 acttaaaaga aactaaacaa gaattaaaaa gagttacatg gccgacaaaa aaggaactgt
      541 ttaaaaacac aagtatagtt ttaactgtag ttatttcatg cactatatta gtatggggta
      601 tagacactat attatctggt gcactagcgt tattactaaa atagacgaaa agaggtaagt
      661 taaatgtcag aattacaaga agcaagttgg tatgtagttc atacctattc gggacatgaa
      721 aataaagtta aagctacaat tgagaaagca gttaaaacaa gaggtatgga agactgcata
      781 agacaagtag ttgttccaac agaagaagta gtggaaacta ctaaaactgg aaaagaaaaa
      841 actagacaac gtaaagttta tccaagttat gttttggtta aaatgataat aactgatgaa
      901 tcttggtatg tagtaagaaa tactaaggga gttacaggtt tcgttggacc tggttcaaaa
      961 ccagtgccat taagtgaaga cgaagtcaaa gctatgggga tagacacaac agaccctaaa
     1021 gtagtaaata gcgatattga ttttgaaata ggagatacag taaaagtatc tcaaggacca
     1081 tttagtggac aaataggtaa catagaagaa attgacttag aaaatagaga agtcaaagta
     1141 tgcataaatg catttggtaa aaggactcta tttgtaatag agcttgaagg tatagaaaaa
     1201 atctaatact atattataga aaaatctgag gaggtgcgct caaaatggct aaaaaagtta
     1261 taggtcaaat aaaattacaa atacctgcag gaaaggctac tccagcgcca ccagttggac
     1321 cagcattagg acaacatggt gttaatataa tgggattcac aaaagaattt aatgctaaaa
     1381 ctgcagatca agctggaatg ataataccag ttgttataac tgtatatcaa gatagatcat
     1441 tcagttttat aacaaaaact ccaccagctg cagttttaat taaaaaagca ttaaacttaa
     1501 aatcaggttc tggagaacca aacaagaaaa aagttgctaa aatgacttca gctcaagtaa
     1561 gagaaatagc tgaattaaag atgcctgact taaatgctgc atcagtagaa gctgctatga
     1621 gtatgatagc tggtactgct agaagcatgg gtgttgtaat cgaagactaa ttaaaagata
     1681 cacttttttt tataaagtgg gaggctagaa gccgaaatta accacgagga ggaaaataaa
     1741 atggctaaaa aaggtaaaag atatgcaggt gcattacaaa aagtagatag aactaaattt
     1801 tatgatgcat cagaagcatt aacattagtt tcagatatag ctggagctaa atttgatgag
     1861 acagtagaag cacacattaa attaggtgtt gactcaagac atgctgacca acaagtaaga
     1921 ggtgcagttg tattacctca tggaactggt aaaacaaaaa gagttttagt ttttgctaaa
     1981 ggtgaaaaag ctaaagaagc tgaacaagct ggtgctgact ttgtaggagc tgaagaatta
     2041 gttcaaaaaa tacaaggtga aaactggttt gactttgata tagtagttgc tactccagat
     2101 atgatgggtg tagtaggtag attaggtaga gtattaggac ctaaaggttt aatgccaaac
     2161 cctaaatcag gaacagttac atttgatgta gctaaagcta tagatgaaat aaaagctggt
     2221 aaagttgaat acagattaga caaaactaac ataatacacg ttccagtagg aaaagtatca
     2281 tttggtggag aaaaattaac tgaaaacttt actgcattaa tggatgctat aataaaagct
     2341 aaaccagctg ctgctaaagg acaatattta agaagtataa cagtagcttc ttcaatggga
     2401 cctggagtta aaataaaccc agcaagaaca gctgaataat aaaactgttg acacaggttg
     2461 acaaaaatgt tattatatca cttgtcaatg taaaaaagaa tagatttgcc gtagatagtg
     2521 ggtgcgaaag cttaatatcc cgccgaggtt ttagataaat tgagattact aaagcttttg
     2581 atgtctactt ttggcaacaa aagcttttta taatgttgcg gtaaatacta agcctatttg
     2641 gtgaaggagg tgcacatcta tatgagaaaa gctatagaaa ttaaatcaga agttgtttct
     2701 gagatagttg aaaagttaca aaaatcttct gctgctgttg ttgtagatta caaaggatta
     2761 acagttgaag aagtaactga gttaagaaaa caaatgagag aagctggtgt agattacaaa
     2821 gtatacaaaa atactttagt tagaagagca gctaaagaag ttggtataga gcaatttaat
     2881 gatgaattat tagttggaac taatgccata gcatttggat atgatgatcc agttgctcca
     2941 gctagaatat taaaaggatt catggattct catccaaaaa tgaaattaaa gatgggtatt
     3001 gtggaaggtg cattctatga tgaatctaag attgttgaaa tggctaacat accatcaaga
     3061 gaagttctta tcgctaaatt acttggtagc ttaaaagctc cagtatcaaa cttcgcatac
     3121 ttaatagatg caatagcgaa aaaggcagaa ggtcaagaag aagcttaatt gcttaactaa
     3181 aaaattataa atattaattt gaaataaaat tcggaggtgc taaaaatgac aatagaacaa
     3241 atattagaag ctatagaaaa tatgaaagtt ttagaattaa atgaattagt taaagctgct
     3301 gaagaaaaat tcggtgtatc agcttcagct ccagtaatgg tagctggtgc agctgctggt
     3361 ggaccagctg ctgaagaaaa aactgagttt gatgtagtat taactgacgt tggttcttca
     3421 aaagttggag ttataaaagc agttagagaa ataacaggat taggattaaa agaagctaaa
     3481 gaagtagttg acaatgctcc taagacagtt aaagaaggag cttctaaaga agaagctgat
     3541 caaataaaag agaaattaga agctgctgga gctaaagtag aagttaagta gtttctttaa
     3601 aaagataccc attgggtatc tttttttatt tataaaaaac tataaagaaa gtatttggaa
     3661 ttataaagaa agtattttta taaaataaaa aaaatttata taatagtact aaattaaggg
     3721 tatcatatat ggtgtaatgg tattttaatt taacattatt atcaaattaa aatataaaca
     3781 attgttgtaa tgtctgtata taaagtatat aattaaacta aaatgtaaaa ttttacattt
     3841 tagtttaaaa aaatacacga gtgtttataa ataaaatgta ataaataatt aattaacaaa
     3901 tataaatttt aaaataagtt agatatttag aaaaatcgaa atttgtagga tttaaaggac
     3961 atattcaagg aggagttaat aatggaaaaa ttacaaggaa aaattgcagt agttactgca
     4021 gcaacaaaag gtattggatt agcatcagca gagatattag caaaaaatgg agcaactgtg
     4081 tacttagcag ctcgttcaga agaattagct aatgaagtta taaataaaat aagtgcagaa
     4141 ggtggttgtg ctaagtttgt ttactttaat gctcgtgaag aagagacctt tacctcaatg
     4201 atagaagagg tagttaaaaa agaaggtaag atagatatac ttgtaaacaa ttttggttca
     4261 acaaaccctt ctcttgacaa agaccttgta actggggata cagataattt ctttgacaca
     4321 gtaaatacta atttaaaaag tgtgtattta ccatgtaaag cagcaattcc tcatatgata
     4381 aagaatggaa aaggaagtat agtaaatata tcaagtatag gttcagtatt acctgattta
     4441 tctagaatag cttactgtgt atcaaaagca gcaatcaact cattaactca aaacatagct
     4501 acacaatatg ctaaagacaa tgttagatgt aatgctgtac ttccagggct tattgcaact
     4561 aaagcagcat tagacaatat gtctccagag ttcataaaag aatttttaaa gcatgttcct
     4621 ttaaatcgta taggggaacc agatgatata gcaaaagctg ttctattcta tgctagtgat
     4681 gactcatcat ttataacagg ggatttactt gaagttgcag gaggatttgg tttacctact
     4741 ccacaatttg cagataatat attaggataa ttaaattact aatatgcaat gaaagcttat
     4801 gcattagtta tagtagaaat gatattttta taaaggccat agatataatt tatattggaa
     4861 aggtttgagg ttcaaaattc caagttaaat ttatttatgg tctttatttt gtatatttta
     4921 ataaattgta tatatttgta taaatgtaat tatttacaat cattttaata tggaattata
     4981 attaaatagg ggggatggta cttgtataaa attttttata gaaaattaga cctataaatg
     5041 aaaaatatgg attttatatt ggaaaattgt acataataca taatatatgc ttaaaataat
     5101 ttacaaaaaa tcaaaaataa tgcatagttt acatataaga taaaaaatat attgaaaaat
     5161 acttgacatt atgctaaaat tattagatgc gttagaatga actattgttt tatttttaat
     5221 tattgagagg tgaaaagtga atgccacatc ctgtcacgat aggtaaaaga actagaatga
     5281 gcttttctaa aattaaggaa atagctgatg tgccaaatct tatagaaatt caagtagatt
     5341 cctatgagtg gtttttaaaa gaaggtttaa aagaagtgtt tgatgatatt tcaccaatag
     5401 aagattatac tggtaatctt atattggaat ttgtcgacta ttctctagat gataaaccaa
     5461 agtacgatat agaagagtgt aaagagagag atgctacata ttgtgcacct ctaaaggtta
     5521 aggtaagact tataaataaa gaaacaggtg agataaaaga acaagaagtg tttatgggtg
     5581 acttcccttt aatgacagaa agaggaactt tcgttataaa tggagcagaa agagttatag
     5641 taagtcaatt agttagatct cctggtgttt actatgcgga agaaagagat aaaacaggta
     5701 agagattgat ttcatctact gtaattccta atagaggagc atggttagaa tatgaaacag
     5761 attctaatga tgtaatatct gtaagagttg atagaacaag aaaacaacca gttacagttt
     5821 tacttagagc tttaggaata ggaacagatg cagagataat tgacctttta ggagaagatg
     5881 agagattatc tgctacatta gaaaaagata atactaagac agtagaagaa ggtcttgtag
     5941 agatatacaa aaaattaaga ccaggtgaac ctcctactgt agaaagtgca tcatctttat
     6001 taaatgcttt attctttgac ccaaaaagat atgacctagc aaaagttggt agatataaat
     6061 tcaataagaa acttgcttta tgttatagaa taatgaataa aatttcagca gaagacataa
     6121 taaatccaga aactggagaa gtatttgtaa aagctggaga aaaaataagc tatgatttgg
     6181 ctaaagccat acaaaatgca ggtataaatg tagtaaatct actaatggat gatgataaaa
     6241 aagttagagt tataggaaat aattttgtgg atattaagtc tcacattgat tttgacatag
     6301 atgatttaaa cataaaagaa aaagtacatt atccaacttt aaaagaaatt ttagatggat
     6361 atagtgatga agaagaaata aaagaggcta taaaatcaag aattaaagaa cttataccaa
     6421 aacatatatt attagatgat ataatagctt caataagtta tgagttcaat atattctata
     6481 atataggaaa tattgatgat atagatcacc taggaaacag aagaataaga tctgtaggtg
     6541 aattgttaca aaatcaagtt agaattggtc tttcaagaat ggaaagagtt ataaaagaaa
     6601 gaatgacggt tcaagatatg gaagctataa cgcctcaagc gttagttaac ataagaccag
     6661 tttcagctgc aataaaagaa ttttttggta gttctcagtt atctcagttc atggatcaaa
     6721 caaatcctct atctgagtta acgcataaga gaagattatc agcccttggg cctggaggtc
     6781 tttcaagaga aagagctgga ttcgaagtgc gtgacgttca ccattcacac tatggtagaa
     6841 tgtgtccaat agagactcca gagggaccaa atatcggtct tataaactct ctaggaactt
     6901 atgcaaaaat aaatgaattt ggatttatag aatcaccata tagaaaattt gataaagaaa
     6961 catcaacagt tactgatgaa atacattatt taactgctga cgaagaagat ttattcgtaa
     7021 gagctcaggc aaatgagcca ttaacagaag atggtaaatt cgtaaaccat agagttgttt
     7081 gtagaactgt aaatggtgct gttgaaatgg ttcctgaaag tagagtagat tacatggata
     7141 tatctcctaa gcaggttgta tctgttgcca ctgctatgat acctttctta gaaaatgatg
     7201 atgccaaccg tgcccttatg ggagcgaaca tgcagcgtca ggcagtgcct ctagttagaa
     7261 gagaagcacc aattatagga actggtatag aatacagagc agcaaaagac tctggagcag
     7321 ttgttgttgc tagaaattct ggtatagcag aaagagtaac agcagatgaa ataattataa
     7381 aaagagaaga tggaaacaga gatagatata atctacttaa gtttaaacgt tcaaactcag
     7441 gtacttgtat aaatcaaaca cctataataa ataagggtga ccagataata aaaggtgatg
     7501 ttatagcaga tggtccagca actgatttag gagaagttgc acttggaaga aactgtctta
     7561 tagcattcat gacttgggaa ggttataact acgaggatgc tatattaata aatgaaagat
     7621 tagttaaaga agatagatta tcaacaattc atatagaaga atatgaatgt gaagctagag
     7681 atacaaaact agggccagag gaaataacta gagatatacc taatgttgga gatagtgcaa
     7741 ttaagaactt agatgacaga ggtataataa gaataggtgc agaagtagac tcaggtgata
     7801 tattagttgg taaagtaact ccaaaaggag aaactgaact tactgctgag gaaagattac
     7861 ttcgtgcaat atttggagaa aaggctagag aagttagaga tacttcactt aaagtgcctc
     7921 atggtgaatc tggtataata gttgatgtaa aagtatttac tagagaaaat ggagatgatt
     7981 tatctccagg agtaaatgaa ttagtaagat gctatatagc taaaaagaga aaaataaaag
     8041 ttggagataa aatggctggt cgtcatggta ataaaggggt tatctcaaga gtattacctg
     8101 aagaagatat gccattcatg gaaaatggaa caccactaga cataatactt aacccacaag
     8161 gtataccatc acgtatgaac attggtcagg ttttagaagt tcatttagga cttgctgcta
     8221 agacattagg atggtatgta gcaacatcag tattcgatgg tgctaatgag tatgacataa
     8281 tggatgctct tgaagaagct gggtatccta gagatggtaa attaacttta tatgatggta
     8341 gaacaggtga gtcttttgac aacagaataa ctgttggata tatgtactac ttgaaactac
     8401 atcacttagt agatgaaaaa ctacatgcaa gaagtactgg accatactca ttagttactc
     8461 aacagccact aggtggtaaa gcacaatttg gtggacaaag atttggagag atggaggttt
     8521 gggctctgga agcatatgga gctgctcaca tacttcaaga aatacttact gttaagtctg
     8581 atgacgttgt aggtcgtgtt agaacatatg aagctatagt taaaggtgaa aatatacctg
     8641 aaccaggaat cccagaatca tttaaggttc ttataaaaga acttcaaagt ttatgcttag
     8701 atgtaaaagt attgacagat gaagaccaag aaatagaagt aagagaatct gtggatgaag
     8761 atgatacaat aggtgaattt gagctagatg ttgtaaatca tatgggagaa gttgaagaaa
     8821 gtaatataat agaagaaatt gaagatgatt ttgcagaaaa tgcagaagat gaggatatag
     8881 agaatttaga agaattcact gaagatgatt tatttgaaga agaaatagat tttgatagtg
     8941 atgactttga tatgtaaatt taattaatgt aaatctcaaa tagaagggag agaactcctt
     9001 gtttgaatta aacaatttcg agtcgataaa aatagcattg gcttctccag aaaaaataag
     9061 acaatggtct aggggagaag ttaaaaagcc agaaactata aattaccgta ctttaaaacc
     9121 agaaaaagat ggtcttttct gtgaaagaat atttggacca caaaaagact gggagtgcca
     9181 ctgtggtaaa tatagaagag ttagatataa aggtgtagtt tgtgatagat gtggagtaga
     9241 agtaactaaa tcaaaagtaa gaagagagag aatgggacat atagagctag ctgctcctat
     9301 gtctcacatc tggtacttca aaggtatacc aagtagaatg ggacttttac ttgatatgtc
     9361 accaagatcg ttagaaaaaa tattatactt tgcctcatat gtggtagttg atccaggaga
     9421 gactggatta aacgaaaaac aattgcttac agaaaaagaa tacagaactg ctcttgaaaa
     9481 gtatggatat acttttactg taggaatggg tgctgaagct gtaaaaacat tactacaaaa
     9541 tatagattta gagcaacaaa gtaaagacct aagagcggag ttaaaagata gtacagggca
     9601 aaagaaagtt agaacaataa gaagattaga agttgtagag gcatttaaaa agtctggaaa
     9661 taaaccagaa tggatgattt tagatgcaat accagtaata ccaccagatt taagaccaat
     9721 ggtacaactt gatggtggaa gatttgcgac ttcagaccta aatgatttat atagaagagt
     9781 tataaataga aacaacagac ttaaaagatt attagagctt ggagctccag atataattgt
     9841 aagaaatgaa aaaagaatgc ttcaagaagc tgttgatgca ttgatagata atggtagaag
     9901 aggtagacct gtaacaggac ctggaaatag accacttaaa tctttatcag atatgttaaa
     9961 aggtaagcaa ggtcgtttcc gtcaaaactt acttggtaag cgtgttgact actcaggacg
    10021 ttctgttata gttgttggac cagaacttaa attttatcaa tgtggacttc caaagaagat
    10081 ggcattagaa ttattcaagc catttgttat ggataaatta gttaaagaag gttatgcaca
    10141 taatataaaa agtgcgaaat ctatagtaga aaaagttaag ccagaagttt gggatgtttt
    10201 agaagatgtt ataaaaagtc atccagttct tcttaaccgt gcaccgactc tacatagatt
    10261 aggtatacaa gcatttgaac caatcttagt tgaaggtaag gctataaaac tacatcctct
    10321 tgtatgtaca gcttataatg cagactttga tggtgaccaa atggcagttc atgtaccttt
    10381 atcagtagaa gcacaagcag aagcaagatt cttaatgctt tctgtaaata atatacttgc
    10441 tcctaaagat ggttcaccta taactactcc atctcaggat atggttttag gttgctatta
    10501 tctaacaata gaagcccaag atggagctaa aggaacaggt atggtattta aagactttaa
    10561 tgaactatta cttgcttatt acaataaatc agttcatcta catgcattag tgaaacttaa
    10621 ggtaacactt gaagatggaa gaagttcatt ggttgaaagt actgttggta gatttatatt
    10681 taatgaaaat atacctcaag acttaggttt tgtagataga aaagaaaatc catttgcact
    10741 tgaagttgat ttcttagcag ataaaaaatc tcttggtaaa ataatagata aatgctttag
    10801 aaaacacgga aatacagaaa cagctgaatt actagattat ataaaagctc taggatttaa
    10861 atattctaca ttaggtggca taacagttgc tgttgatgat atgagtgtcc cagaagaaaa
    10921 gaaagtattt atagctgagg cagaagctaa agttgataag tatgaaaaag catacagaag
    10981 aggtctaatc tctgatgaag aaagatatga aaaagttata gagacatgga cagaaacaac
    11041 tgataaagtt actgatgctc ttatgggtgg actagataga ttaaataata tatatataat
    11101 ggcacattca ggagccagag gttctaaaaa ccaaattaga cagctggcag gtatgcgtgg
    11161 tcttatggca aatgcatctg gtaaaacagt tgagatacca gttaaatcta atttccgtga
    11221 aggtttatca gtactagaat actttacatc ttcacatggt gccagaaaag gtcttgccga
    11281 tacagctata cgtacagctg aatctggata tttaacaaga agacttgttg atgtaagtca
    11341 agatgttatt gtaagggaaa tagattgtgg aacagaagat actacagaga tttatgctat
    11401 aaaagaagga aatgaagtta tagaagagat atatgataga attgtaggaa gatatactat
    11461 agaccctata ttaaatcctg aaactggaga agttatagtt gaggctgatt caatgataca
    11521 agaagatgaa gcagaaacta tagtagcttt aggaattgaa aaaattagga taagaacagt
    11581 tcttaactgt aaaactaatc atggagtttg ttctaagtgt tatggtagaa acttggcaac
    11641 aggaaaagaa gttaatatag gtgaagcagt tggtataata gcagctcaat ctatcggtga
    11701 gccgggtact cagcttacaa tgcgtacatt ccatactgga ggagttgcag gagctgatat
    11761 aactcaaggt ctaccaaggg ttgaagaatt atttgaagct agaaaaccaa aaggattagc
    11821 tgtaataact gaagtatctg gtagagttga aattgatgaa acaggaaaga gaaaagaagt
    11881 aaatgtaata ccagaagaag gcgagactca aacatatgta attccatatg gttctagatt
    11941 aaaagttaag caaggtcaaa tgctagaggc tggagaccct ctaacacaag gatttataaa
    12001 tcctcatgat atagtaagag taaatggtgt taagggagtt caagaatata tagttaaaga
    12061 agttcaaaga gtgtatagac ttcaaggggt tgatgttaat gataagcata tagaagttat
    12121 agtaagacaa atgctatcta aagtaaaagt tgaagaccca ggagatacag atttattgcc
    12181 aggtggatat gaagatgtat taacattcaa tgaatgtaat aaagatgcta tagataaagg
    12241 tctaagacca gcagttgcta aaagagtttt acttggtata actaaagcat ctcttgcaac
    12301 tgattcattc ttatcagcag cttctttcca agaaacaaca agagtattaa cagaggcagc
    12361 aataaaaggt aaagaagacc acttaatagg acttaaagaa aatgttatat taggtaagtt
    12421 aataccagca ggaacaggaa tgaagaaata tagaaatata gctgttgaaa aaattgaaga
    12481 ttaatagcat atagagtaaa gaaatcttga caaccattat ttgtggtgtt aaaatagtaa
    12541 agtgtgttgt ttaaaagtac actaagggct tgaacaagtt cttagtgact tttagatggc
    12601 aataaatgag aactaaaaag catcaagcta gaaaagtgct aatatcacat atttatgtgt
    12661 tatagacatt aaattgtaag taacgaatgt tacaatcagt cagtatgaat attcatattg
    12721 atgtagttgg cggtcactga taagatcgaa aatttggaag gaggtgcaga tgatgccaac
    12781 aattaaccaa ttagttcgta aaagtagaaa agcgctagag aagaaatcta ctgctccagc
    12841 attacaaaaa ggttacaact ctttaaataa gaaagtaact gacgctagtg ccccacaaaa
    12901 aagaggggtt tgtacttcag taaaaacagt tactcctaag aagcctaact cagctttaag
    12961 aaaagttgcc agagttagat taactaatgg tatagaagtt tctgcttata taccaggaga
    13021 aggacacaac ttacaagagc atagtgttgt tcttataaga ggaggaagag taaaagacct
    13081 tccaggggtt agataccata tactaagagg tactctagat acagcaggtg ttgataagag
    13141 aagacaatca agatctaaat acggtgcgaa gagacctaaa gaagctaaaa agtaaaaaca
    13201 attaatgatt gattatagtt cggtgcttta aatatatata tatttacggc atcacggcat
    13261 taaatgattt atgtcgagta cctatgattt aagttaaata attaaggagg gaagcgaaat
    13321 gccaagaaaa ggtaatattc caaaaagaga agttttacca gatcctatgt atgggagtaa
    13381 ggtagttact aaattaataa ataatctaat ggtagacgga aaaaaaggaa agtctcaaag
    13441 aatagtttat gatgctttcg caattgttgc tgaaaagaca ggagaagaag ctttagaagt
    13501 atttaataaa gcaatggata atataatgcc tgttttagaa gtaaaagcaa gaagagttgg
    13561 tggggcaaac taccaagtgc caatcgaagt tagacctgaa agaagacaaa cattaggttt
    13621 aagatggcta gtaaaatata ctagagctcg tggagaaaaa ggaatggttg aaaagctagc
    13681 taaagagata atggacgcag ctaacaacac tggagcttca gttaagaaaa aagaagatac
    13741 tcataaaatg gcagaagcta ataaagcatt tgctcattac agatggtagg atatatagat
    13801 atcttataaa attgaggata tcataaggag gataaccatg gctagaaagt ttcctttgga
    13861 aagaactagg aatataggaa tcatggctca tatagatgca ggaaaaacta ctactacaga
    13921 aagaatcctg ttttatactg ggcaaactca taaaatagga gaaactcatg aaggagcttc
    13981 tcaaatggac tggatggagc aagaaaagga aagaggtata acaataactt ctgccgctac
    14041 tactgcttca tggaaagacc atagaataaa cataatagat actcctggac acgtggactt
    14101 cacagttgag gttgaaagat ctctaagagt tcttgacggt tcagttgctg tattctgtgc
    14161 aaaaggtggg gttgagcctc aatcagaaaa tgtatggaga caagctgaaa cttatggagt
    14221 acctagaata gcttttgtaa ataaaatgga tatattaggt gcagatttct acaatgttgt
    14281 aagcatgatg aaatctagat taaattctaa tgcagttcct atgcaattac caataggtaa
    14341 agaagattca tttataggta taatagactt attaaaaatg gatgctgtta tatacaaaga
    14401 cgacctaggg gttgaaatgg aagaaacaga tataccagaa gatatgaaag aattagctgc
    14461 tgagtggaga gaaaaattag ttgaatcagt agctgaaact gatgaagaat taatgatgaa
    14521 ataccttgaa ggtgaagaac ttactataga tgaattaaaa gttgctataa gaaaagctac
    14581 tatagcttgt gaaatgaacc cagttttctg tggtacagct tatagaaaca aaggtgttca
    14641 gttagtaata gatgcagttt tagattactt accagcgcca actgatatac cagctataaa
    14701 aggtatatta gcagatggag aagaagctga aagacattct tctgatgaag agccattctc
    14761 tgcattagca ttcaaaataa tgactgaccc attcgttgga aaactagcgt tcttcagagt
    14821 ttattctgga acattagaat caggttctta tgttttaaat gcaactaaga ataagagaga
    14881 aagaattggt cgtatattac aaatgcatgc taatacaaga gaagaaataa ctaaagtgta
    14941 tgctggagat atagcagcag cagtaggatt aaaagatact actactggag acacattatg
    15001 tgaccctgct aatccaataa tacttgaatc tatggaattc cctgagccag ttatatctgt
    15061 tgctatagaa ccaagttcta aagcagctca agaaaaaatg ggtatagctc ttcaaaaatt
    15121 agctgaagaa gacccaactt tcacagttaa gactgaccaa gaaacaggac aaactataat
    15181 atctggtatg ggtgaattac acttagagat aatagtagat agattattaa gagaatttaa
    15241 agtagaagct aaagttggtg caccacaagt tgcatataga gagactataa ctcaaccagt
    15301 tgatgttgaa tacaagtact ctaagcaatc aggtggtaga ggacaatacg gtcacgttaa
    15361 gattagagtt gctcctcaag agccaggtga aggatacaaa ttcacaaaca aaactgttgg
    15421 tggatcagta ccaaaagaat atgttggtcc agttgacatg ggtatacaag gagctatgca
    15481 atctggtata gttgctggat atccagttgt agacgttgct gttgagttat atgatggttc
    15541 ttaccatgag gttgactctt ctgagatggc gtttaagatg gctggttcaa tggcattcaa
    15601 agatgctatg aagaaaggta atgcagttct tttagagcct tacttcaaag tagaagttgt
    15661 tactccagaa gattacatgg gagatgttat gggtgactta aactcaagaa gaggattaat
    15721 ccaaggtatg gaagctagaa gtggtgcaca agttataaat gcattcgttc cactttcaga
    15781 aatgtttgga tactcaacag acctaagatc ttcaactcaa ggtcgtgcaa cttacacaat
    15841 gatattcgat cactatgagc aagttccagc ttcagttgct aagaaaatag ctgaaggaaa
    15901 ataatttaaa aataattaat aatataaata taaaaaataa tcagctagat gagagatatc
    15961 tctcatctag cacaagat
//
LOCUS       DAEHWM010000098        15825 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.100, whole genome shotgun sequence.
ACCESSION   DAEHWM010000098 DAEHWM010000000
VERSION     DAEHWM010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15825)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15825)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15825
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.100"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            41..637
                     /locus_tag="KNP36_003075"
     CDS             41..637
                     /locus_tag="KNP36_003075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3793 family protein"
                     /protein_id="HBF0874925.1"
                     /translation="MSCCNSQFCCKNKIESSYIKWLLEVLGPVFLGSKPAEIINISFT
                     DVNREEKINDIYKYLYKCKKIDFIVIDKEKKGLKILFVNKKALSEKLKCKKTVNFLKF
                     LGYKQNTNVNAYLEHLVDKLKSDVFPDEIGIFLGYPLKDVIGFMGYSNYEVSMIKYWK
                     VYGDTKQSEDTYSKFLLHRKKMRKLLDYISVDKIVSCF"
     gene            complement(735..1694)
                     /locus_tag="KNP36_003076"
     CDS             complement(735..1694)
                     /locus_tag="KNP36_003076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NrtA/SsuA/CpmA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0874926.1"
                     /translation="MTSLIMVLVGTVGCSTTNDKKDEPAKKEASLPKEINLTYVKSPL
                     NVPSILEKKDDLFGKEFKKDNIKVNFHELTTGPEQTQALAAGELDFLHALGGTSAIIA
                     ASNGVGLKITNIYSRSPKGYMLITNNDNIKSIKDLKGKKIVGPKGTILHQLLIAALAK
                     EGYTIDDVEYVNMDIPSAASALESKSADVAMLAGPVALKTINSGAKMIVNGEGLVSGI
                     IVTAVSDDFAEKYPELVKRFMKVHEETLKYMNENKDEVMDVVSKEVGLSLDETKEMYS
                     WYDFSSKITDKDIKELEDTQEFLMSNGMQQKKINIKDMLYNQN"
     gene            complement(1728..2459)
                     /locus_tag="KNP36_003077"
     CDS             complement(1728..2459)
                     /locus_tag="KNP36_003077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874927.1"
                     /translation="MVRSGFLLENIYKKYLVDNKEHLVLDNISLNISSEEITVILGES
                     GCGKTTLLRILAGLENATSGNVYFFNNDKKCTPKVGMVFQESRLMPWLNVSENILLHT
                     EKDNRNKVDLDKYLKMMKLEKFKNSYPNELSGGMAHRVSIARALSFNPDILLMDEPFA
                     ALDYFTRRKMQKEVVNIHKNTKKGVVFVTHNIEEAMEIAKKIIVFSKNKRIKQFSVED
                     EYNRDLTKNYYINLKKEILRELGEF"
     gene            complement(2452..3222)
                     /locus_tag="KNP36_003078"
     CDS             complement(2452..3222)
                     /locus_tag="KNP36_003078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874928.1"
                     /translation="MFEKIHKRLKGYYIFLIILILWKIVCVLGIWSSYILPPPEIVLD
                     TFIKMIYDGSIFLNVYASVRRILIGFLISSLMAIPLGVLFGANKKMYEYFKPLFEFMR
                     STPPLALVPMLILWFGIGEESKIIIIILASFFPIFLNTLKGIKNCDNKLIEVGKSFNL
                     SKKRIFYKIIIPNSMLDIVVGLSLGLGYSFRAIIGAELIAASSGLGYLISDGKDMSRT
                     DVVLVGIFVIGFLGILSDYLFSKIITKFSKGKQVDLNG"
     gene            complement(3307..4017)
                     /locus_tag="KNP36_003079"
     CDS             complement(3307..4017)
                     /locus_tag="KNP36_003079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AIM24 family protein"
                     /protein_id="HBF0874929.1"
                     /translation="MFKFDVTNELMCIARGSGKFFAKKGAMVAFKGNFNFEKLLLGPS
                     NGGGLGRALLGHVQRSLTGEQMPIMVVEGEGEIYLAQNAYHVDVISIDPGDSIYVESE
                     NLLAFSEQLNYSVKLIGSGVISQKGLFTTHLVNKTGQNQDVAIITDGNPLILEGPCCV
                     DPDALVAWTGREPYPKVSKLSWKTFIGQTSGESYHMEFVEPGQIVIIQPSERLSGLKT
                     DSTPSDRMSSGGLRLGID"
     gene            complement(4197..4349)
                     /locus_tag="KNP36_003080"
     CDS             complement(4197..4349)
                     /locus_tag="KNP36_003080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FeoB-associated Cys-rich membrane protein"
                     /protein_id="HBF0874930.1"
                     /translation="MATFIIAAIVVVLMALAVMYMVKNSKKNGSSCGCGCSGCSSSKS
                     CHSAKR"
     gene            complement(4375..6531)
                     /gene="feoB"
                     /locus_tag="KNP36_003081"
     CDS             complement(4375..6531)
                     /gene="feoB"
                     /locus_tag="KNP36_003081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBF0874931.1"
                     /translation="MSIKIGLIGNPNCGKTTMFNGLTGSSQYVGNWPGVTVEKKGGKL
                     KGNKDVEIVDLPGIYSLSPYTLEEVVTRNFMLDDKPDAVINIVDASNIERNLYLTTQV
                     LELGIPTVIALNMMDIVNKNGDKINIKELSEVIGCPVVEVTAVKGQGIMEAAEKAVEL
                     ASSNNKLNFKLPFVDESKDAIEKIEKIIEEKTPYIDVETRWLAIKLFERDENVIQKLD
                     ISKTILNSIEEITRNCEDELDDDSESIITANRYEFISSIISSIIKKNRKGKETVSDKI
                     DKIVTNRILALPIFALIMWGVYYIAVSSLGTIATDWTNDVLFGEIIQGNVSNFLASLN
                     VAEWLQGLVVDGLIGGVGAVLGFVPQIMLLFLLLSILEDCGYMSRVAFIMDRIFRKFG
                     LSGKSFIPMLISSGCGVPGVMSTRTIENDRDRKMTIMLTTFIPCGAKIPIIALFAGAL
                     FGGASWVAPSMYFLGIAMIIICGIILKKTSLFAGEPSPFVMELPQYHIPSAKGVLIHM
                     WDRGKAFIIKAGTIIFVACGVIWFLQSFNWSLQMVDAGDSILASLGNIVAPIFAPLGF
                     GNWQSSVATVTGLVAKENVVGTFGVLFGISDATEQDPTLLASVASMFTVASAFAFMAF
                     NMLCAPCFAAIGAIKREMGSWKWTWITLGFQTLTAYIIALLINQVGSLVLGTGGSIAG
                     AIISIFIAVAVVFVVLTYSNKNMKKEKMGKLSYMKN"
     gene            complement(6631..6852)
                     /locus_tag="KNP36_003082"
     CDS             complement(6631..6852)
                     /locus_tag="KNP36_003082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBF0874932.1"
                     /translation="MNRLKDIKCGETVKVKKLEGEGATRRRIMDMGITRGVNIFIRKV
                     APLGDPIEVTVRDYELSIRKSDAEKIIVE"
     gene            complement(6865..7077)
                     /locus_tag="KNP36_003083"
     CDS             complement(6865..7077)
                     /locus_tag="KNP36_003083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBF0874933.1"
                     /translation="MMPLILSNTGEEVVIKKISGSDKTRTFLNSIGFVVGTNVKIVSK
                     IDGNLIIDVKDTRVALDKKMASRIII"
     gene            complement(7398..10295)
                     /locus_tag="KNP36_003084"
     CDS             complement(7398..10295)
                     /locus_tag="KNP36_003084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0874934.1"
                     /translation="MKAFKKHFLILSLIFLLIISCFNNILCFADESENSKKIRVGYCD
                     DYGIISSSKEHSYTGYGYDYLREISKYTRWEYEFVKGSWEECLDRLEKGEIDLLGPLQ
                     KNDERNKLFNFPKLSSGYEYSALYTKDSNNNMFYEDISSFKGMRVAVLRGNFHNTAFE
                     KYREENNFSVEYIYCNSIDELIESVNEKKADAFVCGSIINAKGMKIVSKFSVEPFYFA
                     TAKDKPNLVKELDYALKELKINDMYYELELYKKYFKREVNNSIAFTRQEMNFIKANPK
                     LTMVYDSEWSPVEYYDEESNSFKGISSDLMSIISKKCGIKFEYIKTKNYNESLDYIKS
                     GKATMLCGSINENDKVKRFNMKLTNPYINIPMIMVGKLDTNLNNDLNIALTSSYKSID
                     SYIEKSFENAKTTSYKSVESCLNAINEGKANLMILSSYQFDELLREGKSENLSVISVL
                     DTSYGMRIGVSNKTDPILVSILNKSIDKITEEELSDCIYSNTIDKPYKVPFGVIFKEY
                     SIQIISFVCILFLIAIKYIIYNKKKKEDYLRKIAYTDPLTGADSIDKFKINSNKLFAK
                     NNPEEYALFYIDVDKFKYINDMFGYDMGNDTLIHISNTIASELKEDEIFARVSADHFV
                     LLIKYKTDDDIKTRLNNIYNKVQILSNPKINYYKLILDCGIYKISKSDNDINTIMDRA
                     NTARKTIKGGHKNSFAFYDKEMHKKILKEKEIENSMVDALNNGEFIVYFQPKYSLSDY
                     QIIGAEALVRWDNPQKGLIPPIEFIPVFERNGFIVNIDFYVFEEVCKKIREWMDEGQK
                     VVPISVNLSRMHFVNSNFIEEFKLIVDKYKIPTRLIELELTETAVLDNIEGLLDTMNN
                     LKEKGFVISMDDFGTGYSSLNLLKELPVDILKLDRAFFTEKDESNNEKIVISNVIKMA
                     KELKMKVISEGVETISQVEFLKQIGCDMVQGYLFSKPMPVKEFEKIAFKKE"
     gene            complement(10622..11230)
                     /locus_tag="KNP36_003085"
     CDS             complement(10622..11230)
                     /locus_tag="KNP36_003085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dienelactone hydrolase family protein"
                     /protein_id="HBF0874935.1"
                     /translation="MVDNLIKYIHKSDVAIVVLHEIYGINSFIEDVCQKYYKYGYDVF
                     CPELLGEKRVFPYSKVQEAYDFFINNVGFDIYKKVEKLINDLKSEYKYVFVAGYSVGA
                     TIAWRCSEDSFCDGIICCYGSRIRDYMDVIPKCPTLLVFAKHDSFDVDSISYQLSRKQ
                     NIQIEILDANHGFIDRYSNNYSDIQTKVFTIKEKSFLSKYLA"
     gene            complement(11490..12035)
                     /locus_tag="KNP36_003086"
     CDS             complement(11490..12035)
                     /locus_tag="KNP36_003086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH peroxidase"
                     /protein_id="HBF0874936.1"
                     /translation="MKKFVCTVCGYIHEGDAAPAQCPVCKVGADKFEEMKGEKNWADE
                     HRIGVAQGVDEEIIEGLRANFVGECTEVGMYLAMSRQADREGYPEVGEAYKRIALEEA
                     EHAAKFAELLGEVVVADTKENLRVRVDAEYGATDGKLKLAKKAKELGLDAIHDTVHEM
                     CKDEARHGKAFLGLLNRYFGK"
     gene            complement(12153..13976)
                     /locus_tag="KNP36_003087"
     CDS             complement(12153..13976)
                     /locus_tag="KNP36_003087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874937.1"
                     /translation="MNLSTGNQKVSRLKKKEKPKDFKKTFKRIFMYFKKDKKITRFIF
                     LLVIIDSIISTVIPYTIGKVVDIIDIDTYSKSIFLKGIIILLSFYIIEFSVKLSKGIC
                     TARLSQSIVKEMRSNLFLKFKNLPITFFDKSSTGDIMSRVTNDVDNISTGISNSLVQL
                     ITGILNILMTFIMMFVLSPILTFCSVILIPIVMFVSNFIAKRTRVFFKQQQVELGKLN
                     AHIEEMISNINVVKSFNYERKSVNDFKEVNDRILNISLKSQIYTSLLMPIMNVISNIG
                     FATICIIGGILASKDIITIGVIASFLSYVRQFTRPLNELANLFNTLLSAIAGCERVFE
                     IIDEQEEQEVHNMFKSEINDNKDGNLNSHFVKGEIELKDVSFSYDSKKKILDNINLKI
                     KAGTSNAIIGETGSGKTTIINLITNFYHIDEGSILLDGKDIYSINRNYLRTCFGVVPQ
                     EGYIFNDTVMENIRYGNLEATDEEVIYASKIANAHKFIVKMREGYSTVLSDRGEDLSE
                     GQKQLISIARAVLKNAPILILDEATSNIDIATEAKIQEAINNLTYGKTSIIIAHRLST
                     ISNCDNIIVLENGRIVESGNHKELIKLKGHYYRNILLTQGK"
     gene            complement(13989..15764)
                     /locus_tag="KNP36_003088"
     CDS             complement(13989..15764)
                     /locus_tag="KNP36_003088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874938.1"
                     /translation="MRYFKKYIKKYIVLFLTAVFFLTLEAFCDLAQPTIMAKIIDIGV
                     SNKNLDYILSTGAIMIGITFLGAIFAIIRSVISARVSQHFSYDLRQDVFEKINTYSLK
                     QIDKFGRASLITRITNDINQMQQFVNGMMRVFIKSPIMCIGSLIIAIKLNLKMSIIIL
                     IAVLIIFIIILLNMKIGYRLFKNVQESTDKVNSKLRQFLSGIKVVKLFCRYDYENQSF
                     EELNDELFKNSRKATTMMSFFRPTITIIINVSIIIILLIGRHLIYSGEIKIGIIVAYV
                     NYMTRILTSLIMISHVFNVFVRAKASYERISEVLVDENEEVIEREESLDVGEKDLKFV
                     NCDIIFENVDFSYNKNTDEKILKNVSFKIEEGQNIGVIGQTGSGKTSLVNLIQKLYII
                     DKGDIKIGGRSIYSISEESLRARIGVVFQNSSVFGKSILENVVMGNRDICKEDVVKSC
                     EIANANQFITKLENTYDEVLFQRGKNLSGGQRQRITIARAIAKKPQILILDDCFSAMD
                     INTETIIRKNIKEYISNLREKESKKCTVITISQKISSIIDCDKILVLDEGEVVGFATH
                     EDLLVSSPIYKKIFALQNLVSEDVN"
BASE COUNT         5249 a         2839 c         1562 g         6175 t
ORIGIN      
        1 ttacttgata ttaattttca tttgaaggag gttatctttt atgtcttgtt gtaattcaca
       61 attttgttgt aaaaataaaa ttgaatcatc atatataaaa tggcttttag aagttttagg
      121 tccagtcttt ttaggctcta aacctgctga aataataaat atttcgttta ctgatgtaaa
      181 tagagaggaa aaaattaatg atatttataa atatctatat aagtgtaaga aaatagattt
      241 tatagttatt gataaagaaa aaaagggatt aaaaatctta tttgtaaata aaaaagcatt
      301 atcagaaaaa ttaaaatgta aaaaaacagt aaacttttta aagtttttag gatacaaaca
      361 aaatacgaat gttaatgctt atttagagca tttagtagat aaacttaaga gtgatgtttt
      421 tcctgatgaa ataggtattt ttttaggata tcctcttaaa gatgtgattg gatttatggg
      481 atatagtaat tatgaagttt ctatgattaa atattggaaa gtttatggtg acacaaaaca
      541 atccgaggac acatattcga agtttttact tcaccgtaag aaaatgagaa aattactaga
      601 ctacataagt gtagataaaa tagtaagctg tttttaattg tgtttttgta taataataaa
      661 aatacaccct cttttaccat acagtttcca taataaataa gggtgtattt tccactttaa
      721 tattttaaag tattctaatt ttgattgtac aacatatctt taatatttat tttcttttgt
      781 tgcattccat tagacatcaa aaattcctgt gtatcttcta attcttttat atccttgtcc
      841 gttattttag aactaaagtc ataccaagaa tacatttctt ttgtttcatc taaagataaa
      901 ccaacttctt tagatacaac atccatcact tcatccttgt tttcattcat atattttaaa
      961 gtttcttcat gaaccttcat aaatcttttt actaattcag gatatttttc agcaaagtca
     1021 tcacttacag cagtaactat tattccactt actaatcctt ctccatttac aatcattttg
     1081 gcacctgaat ttatcgtttt caatgccact ggacctgcaa gcattgctac atcagcactt
     1141 ttactttcta atgcagaagc agcactagga atatccatat ttacatattc aacatcatct
     1201 atagtatagc cttctttagc aagtgcagca atcaacagtt gatgaagtat agtccctttt
     1261 ggacctacaa tttttttacc ttttaagtct tttatagatt taatattatc attattagtt
     1321 ataagcatat atccttttgg tgaacggcta taaatattcg taattttaag accaacacca
     1381 tttgatgcag ctattattgc agacgttcct cctaatgcat gtaaaaagtc tagctcacct
     1441 gctgctaatg cttgagtttg ctctggtcct gttgtcaatt catggaaatt gacttttata
     1501 ttgtcctttt taaattcctt tccaaataaa tcatcctttt tttctaatat actaggaaca
     1561 ttaagtggtg attttacata agttaaattt atttccttag gtaaactagc ctcttttttt
     1621 gcaggttcat ctttcttatc atttgttgtt gaacatccta cagtcccaac caacaccatt
     1681 attaaagatg tcattactgc taaaatcttt ttgtttcttt taatcaatta aaactccccc
     1741 aattccctta atatttcttt tttcaagttt atataatagt ttttagttaa atctctatta
     1801 tattcatctt cgacactaaa ttgtttaatc cttttatttt tactaaaaac aattattttc
     1861 tttgctattt ccatagcttc ttcaatattg tgagttacaa atactacacc ttttttagta
     1921 tttttatgga tatttacaac ttctttttgc atttttcttc ttgtgaagta atctagtgct
     1981 gcaaatggtt cgtccatcag caaaatatcg ggattgaagg aaagtgctct tgctatactt
     2041 actctgtgag ccattcctcc tgataattca tttggatatg agtttttaaa cttttcaagc
     2101 ttcatcattt ttaaatactt gtctaaatca actttatttc tattatcttt ttcagtatgt
     2161 aaaagtatat tttcacttac attcagccat ggcataagtc tactttcttg aaataccatt
     2221 cctacttttg gagtacactt tttatcatta ttaaaaaaat atacgtttcc actagtagca
     2281 ttttcaagcc ctgctaaaat tctaagtagc gttgttttcc cacatccact ttcacctaat
     2341 ataacagtta tctcttcact agatatattt aaagatatat tatcaagaac taaatgctct
     2401 ttattatcaa ctaaatattt cttatatata ttctctagca aaaatccact tctaaccatt
     2461 taaatcaacc tgcttccctt tgctaaattt tgttattatc tttgaaaata gataatctga
     2521 aagtatacct aaaaatccaa taacaaaaat tcctaccaat acaacatcag ttctagacat
     2581 atcttttcca tcagaaatca aatatcctag tcctgaagaa gctgcaataa gctctgctcc
     2641 aattatagcc ctaaaactat acccaagccc taaactaagt ccaacaacaa tatccagcat
     2701 agaattaggg attattattt tataaaaaat tctcttttta gataaattaa aagatttacc
     2761 tacttctatt aatttattgt cacaattttt tatacctttc aatgtattta aaaatattgg
     2821 aaaaaaggat gccaaaataa taattataat tttagattct tcacctatac caaaccataa
     2881 aataagcatt ggcaccaaag ctagtggagg tgtacttcgc ataaattcaa atagtggttt
     2941 gaaatattca tacatttttt tatttgctcc aaataaaact ccaagtggta tagccatcaa
     3001 tgaacttatt aaaaaaccta ttaatatcct tcttacactg gcataaacat ttaagaaaat
     3061 agaaccgtca tatatcattt ttataaaagt atctaagact atttcaggag gaggcagaat
     3121 atagctactc catataccca aaacacatac tatcttccat aaaattaaaa ttattaaaaa
     3181 aatataatat cctttaagcc ttttatgaat tttctcaaac atataaaact ccttttaaca
     3241 tatctatccc tgctaccctt tttatttttt aatatcttaa ataataatta agctatatca
     3301 taagatttaa tctatgccaa gtcttaatcc acctgaactc attctatcag aaggtgtaga
     3361 atctgttttt aagccagaca atctttcaga tggttgtata atgactattt gtccaggttc
     3421 aacaaattcc atatgataag attctcctga agtctgacca ataaaagtct tccatgatag
     3481 ttttgatact ttaggatatg gttctcttcc agtccaagct actaatgcat ctgggtcaac
     3541 acaacaaggt ccttcaagaa ttagaggatt accatctgtt attatagcaa catcttgatt
     3601 ttgacctgtt ttatttacta aatgtgtagt aaaaagacct ttttgagata ttacccctga
     3661 accaatcaat tttacactgt aatttaattg ttcagaaaat gccaataagt tttcactctc
     3721 aacataaatg gaatcacctg ggtcaattga tattacatct acatggtaag cattttgagc
     3781 taggtaaatt tcaccttcac cttcaaccac cattattggc atttgttctc ctgtcaatga
     3841 cctctgaaca tgacctaata atgctcttcc caatccaccg ccattacttg gacctaacag
     3901 caatttttca aaattaaaat ttcctttaaa ggctaccata gcaccttttt ttgcaaaaaa
     3961 tttaccactt ccccttgcta tacacataag ctcgtttgta acatcaaatt taaacataat
     4021 attcacttat attgcttaat ttagcaataa tccctcctaa tcatatattt atatataatt
     4081 atacagtaaa attacagcat agtctaacct acttcaaata tgaaatttgt tatttataca
     4141 aaaaataaga acctgataat aaagcaattt aactttttat caggctctta tcctatttat
     4201 ctcttagcgc tatgacaact cttactactt gagcatccag aacaaccaca tccacaactg
     4261 ctaccattct tttttgaatt tttaaccata tacattacag ctagtgccat taatactact
     4321 acaatagctg ctataataaa tgtagccata ttcatcactc cttatttata tgaattaatt
     4381 tttcatataa cttaatttac ccattttttc ttttttcata tttttatttg aataagttaa
     4441 aactacaaag actactgcta ctgctataaa tatagatatt attgccccag caatacttcc
     4501 tccagtacct aaaactaaac ttccaacttg atttataaga agagcaatta tatacgctgt
     4561 taaagtttgg aatcctaatg taatccatgt ccatttccat gaacccattt ctctttttat
     4621 ggctccaata gctgcaaaac aaggtgcaca aagcatatta aatgccataa atgcaaacgc
     4681 actagctact gtaaacatac ttgcaactga agcaagaagt gttgggtctt gctctgttgc
     4741 atctgatata ccaaataaaa ctccaaatgt tccaactaca ttttccttag ctactagacc
     4801 tgtaactgtt gctactgatg attgccaatt tccaaatcca agaggagcaa atattggtgc
     4861 aactatattt cctaagctag ctaatatact atctccagca tctaccattt gtaatgacca
     4921 attaaatgat tgtaagaacc agattactcc acaagcaaca aatataattg ttcctgcttt
     4981 gattataaat gcttttcctc tatcccacat atgtattaaa acaccttttg cacttggaat
     5041 atgatattga ggtaattcca taacaaatgg agatggttct cctgcaaata aactagtttt
     5101 ctttaatata attccacaaa tgattatcat tgcaatacct aagaaataca ttgatggagc
     5161 tacccatgaa gcacctccaa ataatgcccc tgcaaataat gctattattg gaatcttagc
     5221 tccacatgga atgaatgtag ttaacataat agtcattttt ctatctctat cattctctat
     5281 agtacgagtt gacataactc ctggaactcc acaacctgaa cttataagca ttggtataaa
     5341 tgattttcct gaaagaccaa acttacggaa aattctatcc attataaaag ctacacgtga
     5401 catgtaccca caatcttcta atattgataa taataagaat aaaagcatga tttgtggtac
     5461 aaatcctagt actgctccaa ctccaccaat tagaccatca actacaagtc cttgtaacca
     5521 ctctgctaca tttaaagaag ctagaaaatt acttacattg ccttgaataa tttctccaaa
     5581 cagtacatca tttgtccaat cagttgctat agtacccaat gaacttactg ctatatagta
     5641 aactccccac attataagtg caaaaatagg taatgctagt atacgatttg ttacaatctt
     5701 atctatctta tctgatacag tttccttacc ttttcgattc ttctttatta tacttgaaat
     5761 tattgaacta ataaattcat aacgattggc tgttattata ctttcactat catcatccaa
     5821 ttcatcttca caatttctag ttatttcttc aatactattc aatattgttt tagaaatatc
     5881 aagtttttgt ataacatttt catctctctc aaatagcttt atagctaacc agcgtgtttc
     5941 tacatctata tatggagtct tttcttctat tattttttca attttttcta ttgcatcctt
     6001 actttcatca acaaagggta atttgaaatt taatttattg ttactacttg caagttcaac
     6061 tgccttttca gcagcctcca taattccttg acctttaact gctgttactt ctaccactgg
     6121 gcaacctata acttcagata gttctttaat atttatctta tcaccattct tatttacaat
     6181 atccatcata ttaagagcta taacggtcgg tatacctagc tctaaaactt gagttgtaag
     6241 atataaattt ctctctatat ttgatgcatc tacaatattt attactgcat ccggcttatc
     6301 atctagcata aaattacgtg taactacttc ttctaatgta tatggagata aagaataaat
     6361 acctggtaaa tctactattt ccacatcttt atttcctttt aattttccac cttttttttc
     6421 gactgttact cctggccagt taccaacata ttgtgatgag cctgtaagcc cattgaacat
     6481 tgttgtctta ccacagttag gatttcctat gagacctatt tttattgaca tttccattcc
     6541 ctccattatt atttaaatac atcactgttt gtgatacaga aaatcattct cattatataa
     6601 ttacattaac cctactctaa ttaatcttta ttattccaca ataatttttt ctgcatctga
     6661 cttacgaatt gatagttcat aatctctgac tgttacctca attgggtcac caagaggagc
     6721 tacttttctt ataaatatat taacacctct tgtaatcccc atatccatta tacgtcttcg
     6781 tgtagctcct tctccctcta actttttgac ttttacagtc tctccacact taatatcctt
     6841 cagtctgttc atgtcattac ctccctatat tattattcta cttgccattt ttttatctaa
     6901 tgcaactcta gtatctttta cgtctattat taagttacca tctatcttag aaactatttt
     6961 aacatttgta cccactacaa aacctatact atttaaaaaa gtcctcgtct tatcacttcc
     7021 cgaaattttc tttataacta cttcttcacc tgtatttgat aatatcaatg gcatcatata
     7081 atatccctcc tcttaaagta atttaaatct acaagcaatc gttatcttat atataaatta
     7141 caatacctta aatcttaatc tattaaaata acatcctatt ttttccttct ttttacaatt
     7201 cctaattttg atttaagtct atcacaatag tatatttttt gcaagtgatt attgtattct
     7261 tttgattttt tttctcattt gatttatttt attaataaaa tcgtaaaaat taatacaaaa
     7321 ataaagatgc tctaaaatag tatactcaac taatattaaa gcacctttat tatatatgtc
     7381 attatttaca cattgcttta ttctttttta aaagcgattt tttcaaactc ttttacaggc
     7441 attggcttag aaaacaaata tccttgtacc atatcacacc caatttgctt tagaaattct
     7501 acttgcgaaa tagtctctac accttctgat attactttca ttttcagttc ctttgccatt
     7561 ttaatgacat tagatataac aattttttca ttattactct catctttttc tgtaaaaaat
     7621 gctctatcta gttttaatat gtcaacaggc aattctttta aaagattaag agaggaatat
     7681 cctgtaccaa aatcgtccat agagattaca aatccctttt ctttcaaatt gttcattgta
     7741 tcaagtaatc cttctatatt atctaatact gctgtttctg ttagctctaa ttctataagt
     7801 cttgtcggaa ttttgtattt atctacaatt aatttaaact cctctataaa attactattt
     7861 acaaaatgca ttcgagacaa gtttacagat ataggtacta ctttttgtcc ttcatccatc
     7921 cattctctaa tctttttaca cacttcctca aatacataga aatcaatatt tacaataaaa
     7981 ccattcctct caaatacagg aataaattct attggtggta ttagaccttt ttgtggatta
     8041 tcccaacgaa caagagcctc tgcccctata atttgataat ctgaaaggct atatttaggt
     8101 tgaaaataaa caataaattc tccattatta agagcatcta ccattgaatt ttcaatttct
     8161 ttctctttta atattttttt gtgcatttcc ttatcgtaaa aagcaaatga atttttatga
     8221 ccacctttta tagtttttct tgcagtatta gctctatcca taatagtatt tatgtcatta
     8281 tcacttttac ttattttata tataccacaa tctaaaatca atttataata gtttatttta
     8341 ggattactaa gtatttgaac cttattgtaa atattgttta accttgtttt aatatcatca
     8401 tctgtcttat acttaataag aagaacaaaa tggtcagcag aaactcttgc aaaaatttca
     8461 tcttccttta attcacttgc aatagtattt gatatatgta tcaaagtatc atttcccata
     8521 tcatatccaa acatatcatt tatatattta aatttgtcaa catctatata aaacaacgca
     8581 tattcttctg gattattctt agcaaacagt ttattagaat ttattttaaa tttatctata
     8641 ctatctgctc ctgtcaatgg gtctgtatat gctatcttcc ttagataatc ctctttcttc
     8701 tttttattat aaattatata tttaatagca attaagaata aaatacatac aaaagaaata
     8761 atttgtattg aatattcttt aaaaatcaca ccaaatggta ctttataagg tttgtcaata
     8821 gtattagaat atatacaatc acttaattct tcttcagtaa ttttgtctat tgatttattt
     8881 aaaatagaca ctaatatagg gtcagtttta tttgataccc ctatacgcat cccatagctt
     8941 gtatctaaaa cagatataac agataaattc tcactctttc cttctcttaa aagttcatca
     9001 aactgataag aactaagtat cattaagttt gctttacctt catttatagc gtttagacaa
     9061 ctttctacac tcttataaga tgttgtctta gcattttcaa aactcttttc tatataagaa
     9121 tcaatagact tataactact agttaaagca atatttaaat cattattgag attggtatcc
     9181 aattttccta ccataatcat tggaatattt atgtatggat ttgtcaattt catattaaat
     9241 cgttttacct tatcattttc attgattgag ccacatagca tagttgcctt accacttttt
     9301 atgtaatcaa gactctcatt ataatttttt gttttaatat attcaaattt tataccacat
     9361 ttttttgata taattgacat taaatcggaa cttatacctt taaatgaatt gctttcttca
     9421 tcataatact ctacaggaga ccactctgaa tcatatacca tagtaagttt tgggtttgct
     9481 ttaataaaat tcatttcttg ccgagtaaat gctatggaat tattgacctc tcttttgaaa
     9541 tattttttat ataattccaa ctcataatac atatcattta tttttaattc ttttaaagca
     9601 taatctaatt cttttactaa attaggttta tcttttgcag tagcaaaata aaaaggttct
     9661 actgaaaatt tgctaactat tttcattcct ttagcattta taatacttcc acaaacaaat
     9721 gcatctgcct ttttttcatt gacggactca attaattcat caatagaatt acagtatata
     9781 tattcaactg aaaaattatt ttcttctcta tacttctcaa atgcagtatt atgaaagttt
     9841 cctctaagta cagctactct cattccctta aaggaactta tatcttcata aaacatatta
     9901 ttgttactat cctttgtata tagtgcacta tattcatatc ctgaacttag tttaggaaaa
     9961 ttaaatagtt tatttctttc atcattcttc tgtaaaggtc cgagtaagtc tatttcaccc
    10021 ttttctagtc tgtctaaaca ttcttcccaa gaccctttta caaattcata ttcccatctt
    10081 gtatattttg agatttctct tagataatca taaccatatc ctgtataaga atgctctttt
    10141 gatgaggata ttattccgta gtcatcacaa tatccaactc ttattttttt tgaattttca
    10201 gactcatcag caaagcatag tatattgtta aaacatgata taataagtaa aaatatcaaa
    10261 gaaagtatca agaagtgctt tttaaatgct ttcatattta aaaacctcca atttgccaac
    10321 ttactttaac ttatttcgtt ttctagttgt aactactttt attgtaatgg taaatatatc
    10381 aaattgcaat attctcatat aatattctta ttcaactata atgaatttat tattatctat
    10441 ttaaatacac tatctaatat tagtttctta taagtcataa aagcacaact aacactataa
    10501 ttctagtgat taattttatt tcaaaaaata taataacact actaatattt taaatatcaa
    10561 tagtgtcata aaaacttttc agattaatta aatctttcta tatattttat aataatctaa
    10621 atcatgctaa atatttagac agaaaacttt tttctttaat agtaaatact tttgtttgaa
    10681 tatcagaata attatttgaa tatctatcta taaaaccatg atttgcatct aaaatctcaa
    10741 tttggatatt ttgtttccta gaaagttggt aagaaataga atcaacatca aatgaatcgt
    10801 gctttgcaaa tactaataag gtaggacatt ttggaattac atccatgtaa tctctaatcc
    10861 gagagccata acaacaaatt atgccatcac aaaaagaatc ttcactgcat ctccatgcaa
    10921 tagttgctcc cacgctatac ccagcaacaa atacatattt atactctgat tttaaatcat
    10981 ttataagctt ttcaactttt ttataaatat caaaaccaac attatttata aaaaaatcat
    11041 atgcctcttg gacttttgaa tatggaaaaa ctcttttttc tcccagaagt tcaggacaaa
    11101 atacatcata tccatattta taatactttt gacaaacatc ttctataaag ctattaatcc
    11161 catagatttc atgcaaaaca acaatagcta catcactttt atgtatatac tttatcagat
    11221 tatccaccac ctttacaaaa cagcaaattt tttatactta gtttaatata ttcttcttta
    11281 catgtcaatt tacttttcta aaatcaaatt tatttttgga ttaatcattt atttttaaaa
    11341 gttgtgcatt attactatta aattattctc tattattaaa aatataatcg ttagaaataa
    11401 aaaataaagt acaaataatt aaaaaatatc tcactcataa ctttaaaaat tataagtgag
    11461 atactcctaa aatctacttt atattaaatt tattttccaa aatatctatt taataatcct
    11521 aaaaatgctt taccatgtct agcttcatct ttacacattt catgtactgt atcatgtata
    11581 gcatctaatc ctaattcttt tgctttctta gctaatttta attttccatc agttgcacca
    11641 tactcagcat caactctaac tcttaagttt tcttttgtat ctgcaactac aacttctcca
    11701 agaagttctg caaatttagc agcatgttca gcttcttcaa gagctattct cttataagct
    11761 tctcctactt ctggataacc ttctctatca gcttgtctac tcattgctaa atacattcct
    11821 acttctgtac actcaccaac aaagttagct cttaatcctt cgattatttc ttcatctaca
    11881 ccttgagcta ctcctattct gtgctcatca gcccaatttt tttcgccttt catttcttca
    11941 aatttatcag ctccaacttt acatactgga cattgtgctg gtgcagcatc tccttcatgt
    12001 atatatccac atactgtaca aacaaatttc ttcataatta ctttcctcct aaattttata
    12061 tatcaaatta aattttttat ttattaagtt agtctatata tacccgcacc atataccttt
    12121 aaacaatttt tttaaaagtt ttttctaaat acttattttc cctgtgtcaa taatatgttt
    12181 ctataataat gtccctttaa ttttatcaat tctttatgat ttcctgattc cacaattcta
    12241 ccattttcta aaactattat attatcacaa tttgatatgg tacttaatct atgagctata
    12301 attatacttg tctttccata agttaaatta tttattgctt cttgaatttt agcttctgtt
    12361 gctatatcta tgttacttgt agcctcatcc aaaataagta ttggagcatt ttttaatact
    12421 gctctagcaa tacttattaa ttgtttttga ccttcactta aatcttcacc cctatccgat
    12481 aatacagtac tatatccttc acgcatttta actataaatt tatgtgcatt tgctatttta
    12541 ctagcatata taacttcttc atcagtagcc tccagatttc cataccttat attttccata
    12601 actgtatcat tgaatatata accttcttgt ggaactactc caaaacaagt tctcaaatag
    12661 tttctgttaa tagagtatat atccttacca tctaaaagta tacttccttc atctatatga
    12721 taaaaatttg taattagatt tataatagtt gtttttccac ttcccgtctc tcctatgatg
    12781 gcatttgatg tgccagcttt gatttttagg tttatattat ctaaaatttt cttttttgaa
    12841 tcataagaaa aacttacatc tttaagctca atttctccct ttacaaaatg agagtttaaa
    12901 ttaccatctt tattatcgtt aatctcactt ttaaacatgt tatgcacttc ttgctcttct
    12961 tgttcatcta taatttcaaa aactctttca catccagcta tggctgaaag taatgtatta
    13021 aatagatttg ctaattcatt taaaggtctt gtaaattgtc ttacataact taaaaaacta
    13081 gctataaccc ctatggttat aatatcttta gatgcaagaa tgcctcctat aatacatata
    13141 gttgcaaatc ctatattact aatcacattc ataataggca ttaaaagaga agtgtaaatt
    13201 tgcgatttaa gggaaatatt tagaattcta tcattgactt ctttaaaatc atttacagat
    13261 tttctttcat aattaaaaga ttttactaca tttatgtttg atatcatttc ttcaatatgt
    13321 gcatttagtt ttcccaactc aacttgttgt tgcttaaaaa aaactctagt tctctttgca
    13381 ataaaattac tcacaaacat tactatcggt attaatatta cactgcaaaa ggttaaaatt
    13441 gggcttaata caaacatcat aataaaagtc atcaatatgt ttaagattcc tgtaattaac
    13501 tgtactaatg aatttgatat tcctgtactg atattatcaa catcatttgt cactctactc
    13561 ataatatctc cagtagaact tttatcaaaa aaggttattg gtagattttt aaattttaaa
    13621 aataaattac ttctcatttc tttaactata ctttgagata atctagctgt acatatcccc
    13681 ttagacagtt taactgaaaa ctcaattata taaaatgaaa gtaaaataat tattcctttt
    13741 aagaaaatgg attttgaata agtatcgata tctattatgt caactacctt tccaatagta
    13801 tatggtatta cagttgatat aattgaatca attattacta gcaaaaaaat aaatctagta
    13861 atcttcttat cttttttaaa gtacataaaa attcttttaa acgttttttt aaaatcttta
    13921 ggcttttctt ttttctttaa tctactgacc ttctgatttc cagtacttaa attcaatata
    13981 cttcctcctt aatttacatc ttcacttact aaattctgca acgcaaaaat ttttttataa
    14041 attggagaac taaccagtaa atcttcatgt gtagcaaatc caaccacctc accctcatcc
    14101 aagactaaaa tcttatcaca gtcaattata gaactaatct tttgtgaaat agttattaca
    14161 gtacatttct tactttcctt ttctcttaaa ttacttatat actcttttat attctttctt
    14221 ataattgtct ctgtattaat atccattgca ctaaaacaat catcaagaat taatatttgt
    14281 ggttttttgg ctatagctct agctatagta attctttgtc tctgtcctcc tgataaattt
    14341 ttaccccttt ggaataaaac ttcatcataa gtattttcga gttttgttat aaattgattt
    14401 gcatttgcta tttcacatga ttttacaaca tcctctttgc atatatctct atttcccata
    14461 actacattct ccaatatact ttttccaaac acactactat tttgaaatac tacacctatt
    14521 cttgccctta aactttcttc agaaatactg tatatactac gtcctccaat cttaatatca
    14581 cctttatcaa ttatatataa tttttgaatt aaatttacta aagaagtctt tcctgaacca
    14641 gtttgaccaa tcacaccaat attttgacct tcttctattt taaaggatac gttttttaat
    14701 attttttcat ctgtattttt gttatacgaa aaatctacat tttcaaaaat tatatcacag
    14761 tttacaaact ttaaatcttt ttctccaaca tctaaacttt cttctctctc aattacttct
    14821 tcattctcat caaccaaaac ctcacttatt ctctcataag atgcttttgc cctaacaaaa
    14881 acattaaaaa catgtgaaat cattataaga gatgttaata ttctagtcat atagtttaca
    14941 taagcaacta taatcccaat tttaatttct cctgaataaa ttaaatgcct tccaattagt
    15001 aatattatta ttatggaaac attaatgatt attgtaattg tcggtctaaa aaatgacatc
    15061 atagttgtag cttttctact atttttaaaa agttcatcat ttaactcttc aaagctttgg
    15121 ttctcataat cgtatctaca aaatagttta actactttta ttccacttaa aaactgtctt
    15181 aattttgaat ttactttatc tgtactttct tgtacatttt taaataatct ataccctatc
    15241 ttcatattaa gcaatattat aataaatata attaaaactg caattagaat aattattgac
    15301 atctttaaat ttaattttat agctataatt aaacttccta tacacattat tggtgacttt
    15361 ataaaaactc tcatcattcc attaacgaat tgttgcattt gattgatatc attagtaatt
    15421 cttgttatta atgaagctct accaaattta tctatttgtt ttaatgagta tgtatttatc
    15481 ttttcaaata catcctgtct taaatcataa gaaaaatgct gagaaactct tgccgagatt
    15541 acacttctta ttattgcaaa tattgcacct aaaaaagtta tacctatcat tatagctcct
    15601 gttgatagta tgtagtctaa gttcttattt gaaaccccta tatctattat ttttgccatt
    15661 atagttggtt gagctaaatc acaaaaagct tccaatgtta aaaaaaatac tgctgttaga
    15721 aataatacta tatatttttt tatgtatttt ttaaaatacc tcattcaatc atcccttcat
    15781 agaattttct cattaccaaa agtatatcat aatggctaat ttaat
//
LOCUS       DAEHWM010000099        14895 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.102, whole genome shotgun sequence.
ACCESSION   DAEHWM010000099 DAEHWM010000000
VERSION     DAEHWM010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14895)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14895)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14895
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.102"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..531
                     /locus_tag="KNP36_003089"
     CDS             <1..531
                     /locus_tag="KNP36_003089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pilus assembly protein PilM"
                     /protein_id="HBF0874939.1"
                     /translation="PININNYSIKYKVINSKNDKLNIQVILFPKNIIQLIKNISENLN
                     MNPKTININFDILQKLINLNLIENFSEEGVFIECKKSQLIINITKDKKIRETYLLSKE
                     GKSYEFIKRLLRGFKYVYYYGIENCFIEEYFKYTDKSIEVNPLRLKDKVKVENNFDAD
                     LEDNRINYINSIGMII"
     gene            532..975
                     /locus_tag="KNP36_003090"
     CDS             532..975
                     /locus_tag="KNP36_003090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874940.1"
                     /translation="MKVDKTINFLNGFKKTKPCNKIYKIIIVLILTCILFKSFMYVKS
                     INELEDYISQNKLVDKSKNTLPTTDKTREKFSKIKLNEIKKIYETIGINSITKISIDK
                     NKLEMEGVCSDLDVLNNLRKIKYIKYYYIDSIVRDGEYYRFRIKS"
     gene            990..1574
                     /locus_tag="KNP36_003091"
     CDS             990..1574
                     /locus_tag="KNP36_003091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874941.1"
                     /translation="MRLNNREKNLLKILLILVIILASDIAVSYLEENLTSLKNEKQNI
                     INKINNQDNYQIKDNKHIDDKYIESVELNKNEELKNNFNNSFLDKKTNKDIVLLVENE
                     LRDIVNVEYINQESSLDNHNKKQVNLEIKVNGELANVLKLEGVMKKLRLNNKLEKIEI
                     NKLKVNNFDVQNIPNEYKQEKDNIVECKMTVRVI"
     gene            1827..2864
                     /locus_tag="KNP36_003092"
     CDS             1827..2864
                     /locus_tag="KNP36_003092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009906384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SEC-C domain-containing protein"
                     /protein_id="HBF0874942.1"
                     /translation="MLGRNELCPCGSGKKYKKCCLNKDIVSERACRKTELSQKQYTDL
                     YSKLYDYSRQDKFKEECEKAKEMFYIMQNDSVNEKFERFFNTYLIQDHIMENKKVMTV
                     GFLEENGANLSQSEVSILKSMFESYVSIYEVKEVSAGKIVLKDCLNGNELCTEDVKLL
                     RSFKIGSCMIARIVDIEGTNILIDITISISNEVKDIILKDIMNLFNQYQDVYKDMKSF
                     LIYHTHILYKYIQQLLDPSIAEYLKRERDKNDTKVNSENELAEEECKVLDTLKENVEK
                     ENIDACIEFWNEYKKNHENIKGAENGWAAAVEYYVKKEAGQPITQVQISKKYDISSST
                     LGKRYKDLKIS"
     gene            2945..3310
                     /locus_tag="KNP36_003093"
     CDS             2945..3310
                     /locus_tag="KNP36_003093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874943.1"
                     /translation="MSLSLGNAIAVSTNFIKSNPAVPVYNGEEIYAVIYHIEIGYNNG
                     VSPDTKQYIIIDYKEFDLSMDKKNELINIAKEYCKSKGIVENENLEINLLDNEEAENF
                     LEKVFNNMKVIRGLITKKG"
     gene            3315..3632
                     /locus_tag="KNP36_003094"
     CDS             3315..3632
                     /locus_tag="KNP36_003094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874944.1"
                     /translation="MDYIGIENITPYENTYEFSVYEYDDEITLGSEKLYVCELRVVLI
                     KVNSLYVERLHKSVEAMVLVKNLKKDLDKTLVVNKIKNFVLDEIWVENLVKENIEVIF
                     VES"
     gene            3680..5284
                     /locus_tag="KNP36_003095"
     CDS             3680..5284
                     /locus_tag="KNP36_003095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874945.1"
                     /translation="MLRVSNVKLGIDKDISLLKDVILKKLKIKEKNLVKYSIYKESID
                     ARKKGKMEFVYSVDVEVKDENKILNSKIKDVTKIKEIRYVNVPVGDKKLKNNPLVIGS
                     GPAGLFAGLLLAQMGYEPIILERGLDVDSRTKDISDFWTTRKLKNNSNVQFGEGGAGT
                     FSDGKLTTRIKDIRCRKVLEELVQFGAPDEILYSHKPHVGTDILKNVVKNIRNEIISL
                     GGQVRFNSKVTDIVVSNDSIQSVIINDTEKIDTDTIILAVGHSARDTYEMLYSRGIKI
                     VQKPFAIGARVEHPQDLINKAQYKDFYNHPRLGAADYRLIEHVSNGRTAYTFCMCPGG
                     SVIASASNDFEIVTNGMSEHARDKINANSAFLVNVTPEDFKSDNPLAGVHFQQKYEKL
                     AFELGGKNYNAPVQLVGDFINNKTSLNLGSVEPSYRPGYTLTNLSECLPSFVTETMRE
                     AFISLDKKLNGFAMYDAVLTGVETRSSSPIRIVRDENTLESVSIKNLYPCGEGAGYAG
                     GIVTAAVDGIKCAEKIIQKYTNNTKI"
     gene            5408..7036
                     /locus_tag="KNP36_003096"
     CDS             5408..7036
                     /locus_tag="KNP36_003096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HBF0874946.1"
                     /translation="MNIIISLMGGLGLFLYGMNLMGEGLQKSAGTKLKKIIKLLTSNL
                     FMGVLVGTGVTAVIQSSSATTVMVVGFVNAGIMTLKQAIGVIMGANIGTTVTAQLVSF
                     DLTGMAPVALGVGIILYLFGNKPRIKNIAEILIGFGILFTGMDFMKMAVEPLRDYQGF
                     TDLLVTFGRYPLLGLLLGFGITAIIQSSSASMGMLVALAAEGLVPLSAALPILYGQNI
                     GTCVTSLLSSIGANKNARRAAMMHLIFNVLGTVIFLIFLNKPVVSMVTSWDPSNVARQ
                     IANTHTLFNIISVLILLPFTNLIIKLAIKLVPDRAGDIDEDETKTIKYIDDRMIETPS
                     IALANTIKEALRMGEKAKESLNASMEALVEHSTEKIDKTYRRERLINDLQKAILNYLL
                     KLSKAPLDDDSREVVDTLFNTVNDIERIGDHAKNIAELSQVAIDSNISFSEEGQSELD
                     VMYNRVVSAYTYALESMRTDNVDLACKVIKIEEQVDIMEKSCRANHMYRLNNNLCSIE
                     NGVIYLDVISNLERISDHAVNIAQQVIAKRLGND"
     gene            7301..8650
                     /locus_tag="KNP36_003097"
     CDS             7301..8650
                     /locus_tag="KNP36_003097"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HBF0874947.1"
                     /translation="MGKINFDYSKATEFFCQNEIDVMQPYVDVAHDMLHNKTGLGNTF
                     LGWIDLPKNYDKEEFDRIKKSADKIKSDSDVLLVIGIGGSYLGSRAAIDMVSHSFRNG
                     LKKEQRKAPEVYFVGHNISSTYIMDLLDIIEGKDISVNVISKSGTTTEPALAFRIFKD
                     YLEKKYGKEEARKRIYATTDASKGALRQLATEEGYETFVIPDDVGGRFSVLTAVGLLP
                     IAAAGLDIDAMMKGANDAREAFQNPDLKSNDSYRYAVARTILHRKGKDVELLVNYEPQ
                     LHYVSEWWKQLYGESEGKENKGLFPASVDFSTDLHSMGQYIQDGKRLLFETVLNVENC
                     KRNITISSEEVDLDGLNYLAGKTVDFVNHKAFEGTLLAHTDGKVPNLVINIPQLDEYN
                     FGYLVYFFEKACGISGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEKEKEELEKRLK"
     gene            8806..9885
                     /locus_tag="KNP36_003098"
     CDS             8806..9885
                     /locus_tag="KNP36_003098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBF0874948.1"
                     /translation="MSRRKKGISLVILVAIISSILSSFLTIILVKDNLVSKSTGSSTP
                     IVVNDDGKSQNIYQAVAEKATPSVVGITTTSVDTSNMFAIPTETQGVGTGIIVDSNGY
                     ILTNSHVISDGQATSVNVLFNDGSTTSGKVVWFDQQLDLAIVKVDKTGLTPAEFADSD
                     KVKVGDISIAIGNPLGLDFQKTVTQGIISGLDRTIQTEKTNMTGLLQTDASINAGNSG
                     GPLLNQKGQVIGINTAKASQAEGLGFAIPINTAKSIVEEVIKNGKYEKVTLGIKGTDV
                     SNYEAATGTKLSTDKGVYVAEVISGSSAEKAGVKVGDIITKVGDTDITGMNDLNKKLY
                     TFSKGASTKITVNRGGKAVTINVNF"
     gene            10230..11138
                     /locus_tag="KNP36_003099"
     CDS             10230..11138
                     /locus_tag="KNP36_003099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HBF0874949.1"
                     /translation="MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYT
                     KQVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVG
                     QEYSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAID
                     TCGYAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGANIN
                     IRIPLIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEEL
                     QRPSEEKLEEIKRLFEASNFNTKIGG"
     gene            11143..13512
                     /locus_tag="KNP36_003100"
     CDS             11143..13512
                     /locus_tag="KNP36_003100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HBF0874950.1"
                     /translation="MARGTFERTKKLREESINAEPHISIERAVLMTEAYKKYEGSVEI
                     PVLRALSFKHYIENRTLSINDGELIVGEKGDSPNGAPTYPEICCHTMEDLEVMHNRDI
                     INFSVSEEARKIHKEEIIPFWKKRQTRDKIINAMTPEWLAAYEAGMFTEFMEQRAPGH
                     TVCGDTIYKKGFLDLKKDIEARLKELDFLNDLDAYNKKADLEAMAIACDAMVILGKRY
                     AEKARQMAEEETDEAKKKDLLLIAETCDVVPAHKPETYHQAIQMYWFVHIGVTTELNI
                     WDAFTPGRLDQHLNPFYERDVENGILDRDRAQELLECLWVKFNNQPAPPKVGITLKES
                     STYTDFANINTGGINPDGQDGVNEVSYIILDVMDEMKLIQPSSNVQISKKTPQKFLKR
                     ACEISRKGWGQPAFYNTEAIVQELMEAGKTIEDARLGGTSGCVETGCFGKEAYVLTGY
                     MNIPKILELTLNNGYDPISKKQIGIETGDPRNFQSYEELFEAFKKQLHYMIDIKIEGN
                     AVIENICAKHMPCPLMSTIVDDCIEKGKDYQRGGARYNTRYIQGVGIGTITDSLTAIK
                     YNVFDKKKFDMDTLLKALDANFEGYEAILNLVSNKTPKYGNDDDYADEIMQEIFNAYY
                     NEVTGRPTVCGGEYRVDMLPTTCHIYFGEIMGASPNGRLCAKPVSEGISPEKGGDTNG
                     PTAVIKSCAKMDHIKTGGTLLNQRFAPSVVQGEKGLDNMANLVRAYFNMDGHHIQFNV
                     FDKNVLLEAQKNPQDYKDLIVRVAGYSDHFNNLSRTLQDEIIGRTEQTF"
     gene            13837..14640
                     /gene="proC"
                     /locus_tag="KNP36_003101"
     CDS             13837..14640
                     /gene="proC"
                     /locus_tag="KNP36_003101"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HBF0874951.1"
                     /translation="MKTLGFIGSGNMGSAMIGGIVQSGLVKAEDITVSDLSQVALDKV
                     KEKFGVNTTTDSKVAVTNSDVVIVALKPNICEKALTPLKELIDANKIIVSIAAGKTIE
                     SLESFIGSDKKIVRVMPNTPALVGEGMSALCKNSNVTDEELNMIKALFESFGEAEIVS
                     EYLMDTVTGISGSSPAYVFMFIEAMADAAVLAGMPRQQAYKFASQAVMGSAKMVLETG
                     KHPGELKDMVCSPAGTTIEAVKVLEEEGFRAAVIKSIVACIDKSKDMSK"
BASE COUNT         6146 a         1508 c         2701 g         4540 t
ORIGIN      
        1 ccaataaaca taaataacta ttcaataaaa tataaagtta taaattctaa aaatgataaa
       61 ttgaatatac aagtaattct tttcccaaag aatattattc aattaattaa gaacatttca
      121 gaaaatctaa atatgaatcc aaagactata aatataaatt ttgatatatt acaaaagctt
      181 ataaacttaa atttaataga gaatttttca gaagaagggg tatttataga atgtaaaaaa
      241 agtcagttaa ttataaatat aacaaaagat aaaaaaataa gagaaacata cttgctatca
      301 aaagagggaa aatcatatga gttcataaaa agattattaa ggggttttaa gtatgtttat
      361 tactatggta tagaaaattg ttttattgaa gaatacttta aatatacaga taaatctatt
      421 gaagtaaatc cattaagatt aaaagataaa gtaaaagtag aaaataattt tgatgcagat
      481 ttagaagaca ataggataaa ttatataaat agtataggaa tgattattta agtgaaagtg
      541 gataaaacaa taaattttct taatggattt aaaaaaacta aaccatgtaa taaaatctat
      601 aaaataataa tagtcttaat tttaacgtgt attttattta aatcatttat gtatgtgaaa
      661 tctataaatg aacttgaaga ttatataagt caaaataagc tagtggataa atcaaagaac
      721 actttaccaa caacagataa aactagagag aaattttcta aaataaaact taatgaaata
      781 aaaaaaatat atgaaacaat tggaataaat agtattacta aaatatcaat agataaaaat
      841 aagctagaga tggaaggtgt gtgtagtgat ttagatgttt taaacaattt aaggaaaata
      901 aagtacataa aatattatta catagacagt attgtaagag atggagaata ttatagattt
      961 agaataaaaa gttagatggg tgattatttt tgagattaaa taatagagaa aaaaatctac
     1021 ttaaaatatt gttaatatta gttattatat tggcaagtga tatagcagta agttatttgg
     1081 aagaaaacct aactagtttg aagaatgaaa agcaaaatat aataaataaa ataaataatc
     1141 aagataatta tcaaataaag gataataagc atatagatga taaatatata gaaagtgttg
     1201 aattaaataa aaatgaagaa ttgaaaaata attttaataa ctcattttta gataaaaaaa
     1261 caaataaaga tatagtgtta ttagtagaaa atgaactgag agatattgtg aatgtagaat
     1321 atattaatca agaaagtagt ttagataatc acaataaaaa acaagttaat ttagaaataa
     1381 aagttaatgg agaacttgca aatgtgttga aacttgaagg tgtaatgaag aagttaagac
     1441 taaataataa acttgaaaag atagaaatta acaaattaaa agtcaataat tttgatgttc
     1501 aaaatattcc aaatgaatat aaacaagaaa aagacaatat tgttgaatgt aaaatgacag
     1561 ttagagtcat ataacaaaaa agaatagata aagtaaaaaa ctattatcaa ttaataaaat
     1621 tttatagagg aattagtttt acgataattc atttctacaa gagggattgt tgatgatttt
     1681 atcgaaatcc taattaaagt taatatattg taccaaaata taagtgaatt taatagaata
     1741 tttacttata ctatagattg attaataaaa aaatggtata ataacaaatt gtactttaat
     1801 ttaataataa gggagtggaa gtcatattgt tagggagaaa tgagctatgc ccttgtggaa
     1861 gtggcaaaaa atacaagaaa tgttgtttaa ataaagatat tgtttcagaa agagcatgca
     1921 gaaaaactga actttcacaa aaacaatata cagatttata ttcaaagtta tatgattatt
     1981 caagacagga taagtttaaa gaagaatgtg aaaaagctaa agaaatgttt tatataatgc
     2041 aaaatgatag tgtaaatgaa aaatttgaaa gattttttaa tacttattta atacaagacc
     2101 acataatgga aaataaaaag gttatgacag ttggttttct tgaagaaaat ggtgcaaacc
     2161 taagtcaatc agaagtatca atattaaaaa gtatgtttga atcatacgta agtatttatg
     2221 aggtaaaaga agtttctgct ggaaaaatag tattaaagga ctgtttaaat ggaaatgaac
     2281 tttgtacaga agatgtaaaa cttctgagaa gttttaaaat cggaagttgt atgatagcta
     2341 gaatagttga tattgaagga actaacatat tgatagatat aactataagt atatcaaatg
     2401 aggttaaaga tataatttta aaggatatta tgaatctatt caatcaatat caagatgtat
     2461 acaaagatat gaagtcgttc ttaatttatc atacacatat actatacaag tatatacaac
     2521 agcttttaga cccaagtata gctgaatatt taaagagaga aagagataaa aacgatacaa
     2581 aagttaattc agaaaatgaa ttagctgaag aagaatgtaa agttttagat actcttaaag
     2641 aaaatgtaga aaaagaaaat atagatgcat gtatagagtt ttggaatgaa tataagaaaa
     2701 atcatgaaaa tataaaagga gctgaaaatg gttgggcagc tgctgttgaa tactatgtta
     2761 aaaaagaagc aggacaacct ataactcaag ttcaaatatc aaagaaatac gatataagct
     2821 ctagtacact aggaaagaga tacaaggatt taaaaatatc ttaattaatt ataaaaagct
     2881 ttaagtcata gataaagaat ctatagtata atatatgtat aatgtttaga aagaggtatt
     2941 aataatgagt cttagtttag gaaatgcaat tgctgtatca acgaacttta taaaatctaa
     3001 cccagctgta cctgtgtaca acggagaaga aatatatgca gttatttatc atatagaaat
     3061 aggatataat aatggtgtat cacctgatac caaacaatat ataataatag actataaaga
     3121 gtttgattta tctatggata aaaaaaatga actaataaat attgctaaag agtactgtaa
     3181 atctaaaggt attgtagaaa acgaaaacct tgaaataaac cttttagaca atgaagaagc
     3241 agagaacttc ttagaaaagg tgtttaataa tatgaaggtt ataagaggtc ttataactaa
     3301 aaaaggataa ataaatggac tatataggaa tagaaaatat aacaccttat gaaaatacat
     3361 atgaatttag tgtatatgaa tatgatgatg aaatcacctt aggtagtgaa aagttatatg
     3421 tatgtgaatt aagggttgta ttgattaaag ttaattctct gtatgttgaa agattgcata
     3481 aatcagttga agcaatggtc ttagtaaaaa acttgaaaaa agatttagat aaaacacttg
     3541 ttgtaaacaa aataaagaat tttgtgctag atgagatttg ggtagaaaat ctagtaaaag
     3601 agaatataga agttatattt gtagaaagct aggaataacc ctagcttttt tatattacaa
     3661 tctaagagag gaaaacaata tgttaagagt atctaatgta aaacttggaa ttgataaaga
     3721 tatatcttta ttaaaagatg ttatacttaa gaagctaaaa ataaaagaaa aaaacttagt
     3781 caaatatagt atatataaag aatctataga tgctagaaaa aaaggaaaaa tggaatttgt
     3841 ttattctgta gatgtagaag ttaaagatga aaataaaata cttaactcaa aaataaaaga
     3901 tgtaacaaaa ataaaggaaa tcagatacgt aaatgtacct gtgggtgata aaaaattaaa
     3961 gaataatcct ttggtaattg gtagtggacc agctggcttg tttgcaggtc tgcttttagc
     4021 tcaaatgggt tatgaaccaa tcatacttga aagaggtctt gatgtagaca gtagaaccaa
     4081 agatataagt gatttttgga caactagaaa attaaaaaat aattcaaacg ttcaatttgg
     4141 agaaggtgga gcaggaactt tttcggatgg taaacttaca actagaataa aagatatacg
     4201 atgtagaaaa gtattagaag agttagttca gtttggagca ccagatgaaa tattatactc
     4261 acataagcca catgttggaa cagatatatt aaaaaatgta gttaaaaata taagaaatga
     4321 aataataagt ttaggtggtc aagttagatt taattcaaaa gtaacagata tagttgtatc
     4381 aaatgattct atacaatctg taataataaa tgatactgaa aaaatagata cagatacaat
     4441 tatattagct gttggacata gtgcaagaga tacttatgaa atgttgtatt caagaggtat
     4501 aaaaatagtt caaaaacctt ttgcaatagg agctagagtt gaacatccac aagatttaat
     4561 aaataaagca cagtacaagg atttttataa tcatcctagg ttaggagctg cagattatag
     4621 acttatagag catgtttcaa atggaagaac agcatatact ttttgtatgt gtccaggagg
     4681 tagtgtcata gcatctgcat caaatgattt tgaaatagtt acaaatggta tgagtgaaca
     4741 tgcaagagat aaaataaatg caaatagtgc atttttagta aatgtaacgc cagaagattt
     4801 taagagtgat aatccactag caggtgttca tttccagcag aagtatgaaa aattagcttt
     4861 tgaattaggt ggaaaaaatt ataatgcacc agttcagctt gttggagatt ttataaacaa
     4921 taagacttct ttgaatttag gaagtgttga gccatcatat agaccaggat atacacttac
     4981 aaatttaagt gaatgtttgc ctagcttcgt aacagagact atgagagaag cgtttatatc
     5041 tcttgataaa aaattgaatg ggtttgcaat gtatgatgct gttttgacgg gagtagaaac
     5101 taggtcatca tcaccaataa gaatagtaag agatgaaaat actttagaat cagtgagtat
     5161 taagaatcta tatccatgtg gtgaaggtgc tggatatgca ggtggtatag ttacagcagc
     5221 agttgatggt ataaaatgtg cagaaaaaat aatacaaaaa tacaccaata atacaaaaat
     5281 ttaacataaa cttaatgatt ttttaatatt taacatgaat ttaacattat cactcctata
     5341 atttgataaa atacaatagg ttataaaatt tttagataca gtaatctctt tacaaggagg
     5401 aaataatttg aacattataa taagtctaat gggtggatta ggtctgttct tatatggtat
     5461 gaaccttatg ggagaaggtc ttcaaaaatc tgctgggaca aagctaaaaa agataataaa
     5521 actacttact agtaacctat ttatgggagt tttggtaggt acaggagtta cagcagtaat
     5581 acaaagttca agtgctacta ctgtaatggt tgttggtttc gtaaatgcag gaataatgac
     5641 tttaaaacag gcaataggag ttataatggg tgctaatata gggactactg ttacagccca
     5701 attggtatct ttcgacttaa ctggtatggc cccagtagca ttaggtgtag gtattatact
     5761 ttatttattt ggaaataagc ctagaataaa aaatatagcc gaaatactta taggttttgg
     5821 tatattattt acaggtatgg attttatgaa gatggcagtg gagccactaa gagactatca
     5881 aggatttact gacttacttg ttacatttgg tagatatcca ctacttggat tattattggg
     5941 atttgggatt acagcaataa tacaaagttc aagtgcatct atgggtatgt tggttgcact
     6001 ggcagcagaa ggtctagtgc cattatcagc agcactgcca attctttatg gccaaaatat
     6061 tggtacatgt gtaacttcac tgttatcaag tattggtgct aacaaaaatg cacgaagagc
     6121 agctatgatg catctaatct tcaatgtttt aggaacggtg atattcttaa tattcttgaa
     6181 taaaccagta gtaagcatgg ttacaagttg ggacccaagc aatgttgcaa gacaaatagc
     6241 caatacacat acattgttta atataatatc tgtattgata cttttaccat ttacaaatct
     6301 tattataaaa ctagctataa agcttgttcc tgatagagca ggtgatatag atgaagatga
     6361 aactaaaact attaaatata tagatgatag aatgatagaa actccttcta tagctcttgc
     6421 aaatacgata aaagaagcac ttcgtatggg tgagaaggcg aaggaaagcc taaatgcatc
     6481 tatggaagct ttagtagaac attcaactga aaaaatagat aagacatata ggcgagagag
     6541 attaatcaat gatttacaga aagctatttt aaattattta cttaaacttt caaaagcacc
     6601 tttagatgat gattcaagag aagttgtgga tactttgttt aatacagtca atgatataga
     6661 aagaattggt gaccacgcta aaaatatagc tgaattatcg caagttgcaa tagattcaaa
     6721 tatttctttc tcagaagaag gacaatctga acttgatgtt atgtataata gagttgtttc
     6781 agcatatact tatgcattag aatcaatgag aactgataat gttgatttag cttgtaaggt
     6841 tataaaaatt gaagaacaag ttgatataat ggagaaatct tgtagagcta atcacatgta
     6901 tagattgaac aataatctat gtagtataga aaatggagtt atttatttag acgtaataag
     6961 taatttagag agaatatctg accatgctgt caatatagca caacaagtta tagcaaagag
     7021 attaggaaat gattaaaaat aattaattta aaataatata aaatttaaaa tagaggataa
     7081 ataaaagaga aactttaaat gatacgttta gagtttcttt ttttgtaaat ttatttgact
     7141 aaaattttta aatttataca tagttatagc atttagaaga atcgatttcc tgataataaa
     7201 tgatgagata tgtatgattt tgtggcaaac ttttaaaaaa aacacctata ttttgtgtta
     7261 taatctcttt aaaacgaata tgctgaaaag agggatttaa atgggaaaaa taaattttga
     7321 ttatagtaaa gctacagagt ttttttgtca aaacgaaata gatgtcatgc aaccatatgt
     7381 agatgttgcg cacgacatgt tacataataa aactggttta ggaaatactt ttttaggatg
     7441 gatagacctt cctaaaaatt atgataaaga agagtttgac agaataaaaa aatctgctga
     7501 taagataaaa tcagactcag atgttctttt ggtaataggt ataggaggct cttatttagg
     7561 ttcgagagct gctatagata tggtaagtca ttcttttagg aatggactta aaaaagagca
     7621 aagaaaggct ccagaagtat attttgtagg gcataatata agctcaacat atattatgga
     7681 tttattagat ataattgaag gaaaggatat ttctgtaaat gtaatatcta aatcaggaac
     7741 tactacagaa ccagctctgg cttttagaat atttaaagat tacttagaga aaaagtatgg
     7801 taaggaagaa gcaagaaaga gaatttatgc aacaacagat gcaagtaaag gtgcacttag
     7861 acagttagct acagaagaag gatatgagac ttttgtaata ccagatgatg taggtggtcg
     7921 tttttctgta ttgacagcag ttgggttact tcctattgct gctgctggac ttgatattga
     7981 tgctatgatg aaaggcgcaa atgatgctag agaagcattt caaaatcctg acttaaaaag
     8041 taatgatagt tatagatatg ctgttgctag aacaatttta catagaaaag gaaaagatgt
     8101 agagttatta gtgaactatg aacctcaact acattatgta agtgagtggt ggaaacagct
     8161 ttatggagaa agtgaaggaa aagaaaataa aggtttattc cctgcttctg tagatttctc
     8221 aacagattta cattctatgg gtcaatacat acaagatgga aaaaggcttt tatttgagac
     8281 agtacttaat gttgaaaact gtaagagaaa tataactata agttcagagg aagtagactt
     8341 agatggttta aactatttag caggtaagac tgtagatttt gtaaatcata aagcttttga
     8401 aggaactcta ttggctcata cagatggaaa agtacctaat ttagtaataa atatacctca
     8461 actagatgag tataattttg gatatttagt ttatttcttt gagaaggctt gtggaataag
     8521 tggatattta ttgggagtta atccatttga ccaaccagga gtagaagctt acaagaaaaa
     8581 tatgtttgct ttactaggca aaccaggtta tgaaaaagaa aaggaagagc tagaaaaaag
     8641 acttaaataa ttttaaatag ttaaggttta attaagatta aaataatata atgaaatcat
     8701 cgaaaaggag tttactcaaa atagatgatt tcattttttt tatgaaaaat tgggaaaaat
     8761 atattttgat aatttatatt atattaagat agggagtggt atgagatgtc aagaagaaag
     8821 aaagggataa gtttagtaat attagttgct ataataagtt caatacttag tagttttcta
     8881 acaataattt tagttaagga caatttagta agtaaatcta caggaagttc tacgccgata
     8941 gttgtaaatg atgatggtaa gagtcaaaat atttatcaag cagttgcaga aaaagctacg
     9001 ccatctgttg taggtattac aacaactagt gttgatacta gtaatatgtt tgcaatacca
     9061 actgaaacac aaggtgtagg aactggaatc atagttgatt caaatggata tatacttact
     9121 aattctcatg ttatatcaga tggtcaagct acaagtgtaa atgtattatt caatgatggt
     9181 tcaacaactt caggtaaagt agtatggttt gaccaacaac ttgatttagc tatagttaag
     9241 gttgataaaa ctggactaac accagcagaa tttgctgata gtgacaaagt aaaagttgga
     9301 gatatatcaa tagcaatagg taatcctctt ggattagatt ttcaaaaaac agttactcaa
     9361 gggataataa gtggattaga tagaactata caaacagaaa aaactaatat gactggttta
     9421 ttacaaactg atgcaagtat aaatgcagga aatagtggag gaccattgtt aaatcaaaaa
     9481 ggtcaagtaa ttggtataaa cacagcaaaa gcttctcaag cagaaggatt aggatttgca
     9541 ataccaatca atacagctaa gagtatagtt gaagaagtaa tcaaaaatgg aaaatatgaa
     9601 aaagtaactt taggcataaa aggtacagat gtatcaaatt atgaagcagc aacaggtaca
     9661 aaattaagta ctgataaagg tgtttatgtt gcagaagtaa tatctggttc atcagcagaa
     9721 aaagctggag taaaggtagg ggatattata actaaagtag gagatacaga tataacaggt
     9781 atgaatgatt taaataaaaa gttgtatact ttctcaaaag gtgctagtac aaaaataaca
     9841 gtaaatagag gcggaaaagc agtaacaata aatgtgaatt tctaaatatg accagaaaga
     9901 tagagactac atggtaaagt gtagtctcta tttttattta atttttatag tatatacatc
     9961 taaattaatt aaaatgatgt attgtttata gtttattgct atattttctt ataaaaataa
    10021 atttaataaa tatttaaatt taatttacaa aaacaatata aatatcataa taaaataaaa
    10081 ttttttaata ttactaaaaa tatatagaca aaataataac gaatatagta ttatgtaatt
    10141 gtagaaatgc ttttcatagg tatattctat gaagatgaat tgcataaaaa tgaaaaaatg
    10201 gaatggatat tatttagggg tgaaaaatca tgaatccatt agttataaac ttacaaaaat
    10261 gtagcataca tgatggacca gggataagaa gtacagtatt ttttaaaggg tgtccacttg
    10321 aatgtgtttg gtgtcataat ccagagagtc aaacatatac aaaacaagtt ttgtataatg
    10381 aagaaagatg ttcaaaatgt gaagcatgta taaatatatg ccctcataag gcaatttaca
    10441 aaggtgaaac aaaaatatgc ttagaccaag ataagtgtga gttttgtgaa acttgcttag
    10501 actattgtgt aaacaatgca agagagattg ttggtcaaga gtattctgta agagatttgg
    10561 ttaaagagat agagaaggat agaattttct atgaagaatc aggtggtgga gtaactctat
    10621 caggtggaga agtaatggct caagatatgg acttcatttg tggagtaata aacatgtgca
    10681 aatcaaaggg aatccatgta gcaattgata catgtggcta tgcaaagtca gaaaattatg
    10741 aaagagttgc taaatgtgca gatttgtttt tatatgatat taagcttatt gatgaagata
    10801 agcacataaa atttacagga aaatcaaatg acttaatact gaaaaatgtt aagattttaa
    10861 gtgaattagg ggctaacata aatataagaa taccattaat tgtaggagta aatgtagatg
    10921 atgaaaattt agaggttaaa aaaatgatag agtttttaaa gcctttgaat atacaagcag
    10981 taagtcttct tccatatcat aatattggta aacacaagta tgataaaatt tataaaaagt
    11041 atgaaggaga agaactacaa agaccatcag aagaaaaatt agaggaaata aaaagactgt
    11101 ttgaagcaag taatttcaat actaagattg gagggtaata aaatggcaag aggaactttt
    11161 gagagaacta aaaaattaag agaagaaagt attaatgcag aaccacacat atctattgaa
    11221 agagcagtac ttatgacaga agcttataaa aaatatgagg gaagtgtaga gattcctgta
    11281 cttcgtgctt tatcatttaa gcattatatt gagaatagaa ctcttagcat aaatgatgga
    11341 gaattaatag taggtgaaaa aggtgattct cctaatggag caccaacata tccagaaatt
    11401 tgttgtcata caatggaaga tttagaagta atgcacaata gagatataat aaattttagc
    11461 gtatcagaag aagctagaaa aatacataaa gaagaaataa ttcctttttg gaaaaagaga
    11521 caaacaagag ataagataat aaatgcaatg acacctgagt ggttagcagc atatgaagca
    11581 ggtatgttta cagagtttat ggaacaaaga gctccaggac atacagtttg tggagataca
    11641 atatataaaa aaggattttt agatttaaag aaagacatag aagcaagatt aaaagagcta
    11701 gattttctta atgatttaga tgcatataat aaaaaagcag atttagaagc tatggcaata
    11761 gcttgtgatg caatggttat attaggtaaa agatatgctg agaaagcaag acaaatggca
    11821 gaagaagaaa cagatgaagc taagaaaaaa gatttattac taattgctga aacttgtgat
    11881 gttgtaccag ctcacaaacc agaaacttat catcaagcta tacaaatgta ttggtttgtt
    11941 catatagggg ttactactga acttaatata tgggatgctt ttactccagg aagacttgac
    12001 caacatctaa atcctttcta tgaaagagat gtagaaaatg gaatactaga tagagataga
    12061 gcacaagaat tacttgaatg tttatgggtt aaatttaaca atcagccagc accaccaaaa
    12121 gttggtataa cattaaaaga aagtagcaca tatacagatt ttgcaaatat aaacactggt
    12181 ggaataaatc cagatggtca agatggtgtt aatgaagtta gttatataat acttgatgtt
    12241 atggatgaaa tgaaattgat acaacctagt tcaaatgttc aaataagtaa aaagactcct
    12301 caaaaattct taaagagagc ttgtgaaata tcaagaaaag gatggggtca accagcattt
    12361 tataatactg aagcaatagt tcaagagctt atggaagctg gaaaaactat agaagatgca
    12421 agacttggtg gaaccagtgg ttgtgttgaa actggatgtt ttggtaaaga agcatatgtt
    12481 ctaactggat atatgaacat tccaaaaata cttgaattaa cattaaataa tggatatgac
    12541 ccaattagta aaaaacaaat aggtattgaa actggagacc ctagaaattt ccaatcttat
    12601 gaggaactat ttgaagcatt taaaaagcaa ttacattata tgattgacat aaaaatagaa
    12661 ggaaatgctg tgatagaaaa tatatgtgca aaacacatgc cttgtccact tatgtctaca
    12721 atagttgatg attgtataga aaaaggcaag gattaccaaa gaggtggagc aagatacaac
    12781 actagatata tacaaggtgt tggtatagga actataacag atagtttaac agcaataaaa
    12841 tataatgtat ttgataagaa aaaattcgat atggatacat tgcttaaagc acttgatgct
    12901 aattttgaag gatatgaagc tatacttaat ttagtttcaa ataagactcc taaatatgga
    12961 aatgatgatg attatgctga tgaaataatg caagagatat tcaatgcata ttacaatgag
    13021 gtaactggta gaccaactgt ttgtggtgga gaatacagag tagatatgtt accaacaact
    13081 tgtcatatat actttggaga aattatggga gcaagtccaa atggtagact ttgtgcaaaa
    13141 ccagtttcag agggaatttc acctgaaaaa ggtggagata ctaatggacc tacagcagtt
    13201 ataaaatctt gtgctaagat ggaccacata aaaactggtg gaacattatt aaatcaaaga
    13261 tttgcaccat cagtagttca aggagaaaaa gggttagata atatggctaa tctagtaaga
    13321 gcatacttta atatggatgg tcatcatata caatttaatg tatttgataa aaatgtactg
    13381 ttagaggctc aaaagaatcc tcaggattat aaagacttaa tagttagagt tgcaggatat
    13441 agtgaccatt tcaataattt aagtagaaca ctacaagatg agataatagg aagaactgag
    13501 caaacattct aggtttgctt gtaaataaaa cttcttacta tataaaatcg taactgatat
    13561 aataaagtat aaatggtttg attccatttt taaaatttta gattaattat gagctaactt
    13621 tctaaatagg aagttagctc gttaagttta atgaaaaaat cgttaaattt atatttagta
    13681 aatcatacac atattagtaa gtaatacata caaaagaata atttattata gttataataa
    13741 ggttatattt tataaaaata agataatttt aagcagttaa aataaagtca atttagctac
    13801 tttaaaataa aactaataga aaaaaggaga tttgatatga aaactttagg atttattggt
    13861 tcagggaata tgggaagtgc aatgataggt ggcatagtac agtcaggatt agtaaaggca
    13921 gaagatataa ctgtatcaga tttaagccaa gttgccttag ataaagtaaa agaaaaattt
    13981 ggagtaaata ctacaactga ttcaaaggta gctgttacaa attctgatgt ggtaatagta
    14041 gcacttaaac ctaatatatg cgaaaaggct ttaactccac ttaaagaatt aatagatgca
    14101 aataaaataa tagtatctat agcagcaggt aaaactatag aaagtctgga aagttttata
    14161 ggttcagata aaaaaatagt aagagtaatg cctaatactc cagcccttgt tggcgaagga
    14221 atgtcagctc tttgtaaaaa tagtaatgta acagatgaag agttaaatat gattaaggct
    14281 ctgtttgaat cttttggtga ggcagaaata gtatcagaat atttaatgga tacagttaca
    14341 ggtattagtg gttcttctcc tgcatatgta tttatgttta tagaagctat ggcagatgca
    14401 gcagtattag ctggaatgcc aagacaacaa gcttataaat ttgcatctca agcagtaatg
    14461 gggtcagcta agatggttct tgaaactgga aaacatccag gtgaattaaa agatatggtt
    14521 tgttctccag caggaactac tatagaagct gttaaggtat tagaagaaga aggctttaga
    14581 gcagcagtta taaaatctat tgttgcttgt atagataagt ctaaagatat gagcaaataa
    14641 cagatgtaat taagtttact atatggtttc ttgaattgtt tttttagtgc ttatttatat
    14701 ctatacataa atgtatttgg tataagtaaa ataagagtaa tttactataa aaaggaattt
    14761 aatgattgag tgataattta ttacttaaat attaataatt aaatagatat atttttaact
    14821 atatttgaga tatatcattg tgaaaaaata aaatttataa gtattattgt gaggttataa
    14881 gtagatttat ttaaa
//
LOCUS       DAEHWM010000100        14143 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.103, whole genome shotgun sequence.
ACCESSION   DAEHWM010000100 DAEHWM010000000
VERSION     DAEHWM010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 14143)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14143)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14143
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.103"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(24..2048)
                     /locus_tag="KNP36_003102"
     CDS             complement(24..2048)
                     /locus_tag="KNP36_003102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0874952.1"
                     /translation="MDKKKLILITYDKLNSDHYKEELTNFFGDEIIIETQNILDGIKE
                     NLEGDVVLSLSPLTSNFLIKHFKEDIEIIHGTKALSKLGYEKMMKLPPGTKSLLMTTN
                     KTSAFEMATYLYKIGINHIDFVPTYPDCDEIYDLDTAITPGQIRFIPKYIKNIVDLGW
                     RKISLDTYMSLLVVLKLKNEKFIEKLYKLSKETLSHDFLNTSLDNISKLKTILYMTID
                     EIGDGLIFFNTFNKVTFVNKSLLNMLELDEKLIKSPSLMEYMPKSFLDKITKNLNIDN
                     MIIYIDEIDKKFILSKKPFYLYKNIEGCLITLKDVNNIEILEQKIRSDSVKRGYVAKY
                     KFNNIIGNSSIIKDCIKKAKKMALTDNPILITGETGTGKEAFTQSIHNHSNRKNKPFV
                     AINCASLPSELLESELFGYEDGSFTGAKKGGKKGLFELAHTGTIFLDEIGDMPHDLQV
                     KLLRVLQEKEIRKIGGTSIIPIDVRILAATNKDLEKLIIENKFRMDLFYRISMFTLDL
                     PPLRKRLEDIPLLLESFLKELPYKNIKLDKSLLEALNSYTWMGNIRELRNCVEYMAYM
                     GSNYLTINDLPQNISSKLNNNHMSSNMSIFNDLNQYDKNICISILKSLHMKPMGRTKL
                     MKFMEYNVTEYEVRNMLEYLTRNGYLISSKGRKGSSITEKGIKIIENNII"
     gene            2438..3106
                     /locus_tag="KNP36_003103"
     CDS             2438..3106
                     /locus_tag="KNP36_003103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874953.1"
                     /translation="MSKLESTTEKVEVKWYGYVALILGALFFSGIFKDAPGPLKVLDF
                     NNVLGSFGTLGTINDGVGTLAANFRGDGGTGPRDGWLYALTLIPSVMFALGVVRVIDH
                     LDGMKAAQKLLSPLLKPLLGLPGFAGLTLIASLQSTDAAASMTKELKDDGYIDEKQKA
                     VFCAFQFSGASAITNFFASGAALFPFIGDVPIFIPLALILIMKFVGANLLRLYLNKFD
                     KGEA"
     gene            3108..3593
                     /locus_tag="KNP36_003104"
     CDS             3108..3593
                     /locus_tag="KNP36_003104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjiG family protein"
                     /protein_id="HBF0874954.1"
                     /translation="MSEVAKKEVKVKKGNVIDAFIGGARNGFQISTNSMAPNVIFGFA
                     IISVFNLTGLLDVIGTIFTPVMSIFGLPGVAATAIMTIFISMGGASGVIAGLFTAGQI
                     SQAHVAILLPMLLLSGAQIQFMGRLLGTAELKTKYYPHMFVIATLNGCIAMLIMNYFV
                     V"
     gene            3654..4775
                     /locus_tag="KNP36_003105"
     CDS             3654..4775
                     /locus_tag="KNP36_003105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 peptidase aminoacylase family protein"
                     /protein_id="HBF0874955.1"
                     /translation="MGTNKDYIEYVHKVYDYLHTIPEKGFEEYKTSEFVLKELEKMGF
                     ENINKGVAGTGIIVTIDSKKEGPVFAIRADMDALEFIIDGEKKMIHACGHDGHTSMLL
                     TAAKLIKERNLVKRGKLKILFQPGEEKLYGALRVIDSGLLDDVEEMVGMHLRPGQDCR
                     LGKAIPAMYHCASCIMEFTIKGITCHGSKPHLGVNAVDAVCLAVNAINAIRVNPAIPN
                     SIKVTNISVKGETYNNIPDEAFMALDIRAESNDIIEELKEKAIHAVKTVVSSINAEAV
                     LISKDGVPAAEFDEELVNLAEETIKDVLGADASIGIFKNSGGEDFHYYTQKLKCKTTY
                     IGLGADATPGFHNPNVTFDTKALEYGVDIWCRLVEKRLG"
     gene            5056..6246
                     /locus_tag="KNP36_003106"
     CDS             5056..6246
                     /locus_tag="KNP36_003106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0874956.1"
                     /translation="MSKYNFDRVIDRVGTDCVKWDFRTNCSTKAQKDGLPFWIADMDF
                     ECAEPIIEALRKKVEHKIFGYSSNDSDKYFNAVCDWYKRRFNWEISRKDIIFSPGVVP
                     AVAILVRILTNSNEGVIVQKPVYYPFEAKIKSNNRDVVNNPLIYENGTYRMDYDDLEE
                     KAKCSNNKVLILCSPHNPVGRVWREDELKKVVEICKKYDLWIIADEIHSDLIRKGFKH
                     TPLQSLCPEYKDKIVTCIAPSKTFNLAGMQLSNIIVNNDELKKKYQEEVTAVGVATSP
                     NPFAIVATIAAYNESEDWLNELNDYLDNNIQFIDEYLKENLPKVKLVYPEGTYLAWLD
                     FTAYGLNEVELEDLMFKKANVLFDEGYIFGKEGIGFERINVACPQSLLKECMDRLKTI
                     FENL"
     misc_binding    6380..6635
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            6694..7695
                     /locus_tag="KNP36_003107"
     CDS             6694..7695
                     /locus_tag="KNP36_003107"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HBF0874957.1"
                     /translation="MSTIIPKDYKSSLNVIDTQIAIKKLKDFFEMRLSNELNLIRVSS
                     PLFVLPETGANDNLNGEKAVSFDIPFMNKNAEIVQSLAKWKRLALKKYGFEVGSGLYT
                     DMNAIRKNEELDNIHSLYVDQWDWELVIDKSSRNEKTLKDVVKRLYGVFKDTEIFVCS
                     MYEGIKEILPEEITFITSQELEDMYPELSPKEREDKIVKEKKAVFITQIGKTLISGEK
                     HDGRSPDYDDWELNGDILFYNPVLDSALELSSMGIRVDEESLDRQLKLAGCEERKEFD
                     YHKMLLNGELPYTIGGGIGQSRICMYFLQKAHIGEVQVGVWPQDMIQNCSSAGIELL"
     gene            7799..8188
                     /locus_tag="KNP36_003108"
     CDS             7799..8188
                     /locus_tag="KNP36_003108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1232 domain-containing protein"
                     /protein_id="HBF0874958.1"
                     /translation="MEFLKIIINIVLDILKKILVRFKNAKFGLVFVFDLLKLPDFMTD
                     KRINIVDKIKVISVLIFTISYFVSGVDIIPEMIAGAFGFIDDAIVLIWSIGIVNEEIN
                     KYRVIAKKDKHSNIIENVEFSIKDEEE"
     gene            8349..9557
                     /locus_tag="KNP36_003109"
     CDS             8349..9557
                     /locus_tag="KNP36_003109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dicarboxylate/amino acid:cation symporter"
                     /protein_id="HBF0874959.1"
                     /translation="MKKKIGLVPKLIIGIIVGILIGSYAPEIIVQILVTVSTLFSAFL
                     KFVIPFIIIGFVTAGIADLATGAGKLLGITTGIAYGSTLIAGLLSFAVSTLIFPNFID
                     ASVASQIGDPEAGMLAPIFTIPLEPMVDVTAAIVFAFVMGLGISALRNHGKGETLFNF
                     FQEFQGIVTKTLSTVIIPLLPLYIAGTFANITIAGEVWTILGVFWKVYLVVIPLHFVY
                     MACQFTAAGVFSGKNPVRMLKNQVPGYLTAIGTQSSAATIPVNVGCAEKNGVSKQIRE
                     FVVPLCATIHLSGSMISITGFTTAVLMMNGMPHGIGVLFPYIAMLGIAMVAAPGAPGG
                     AIMSALPFLPMVGIPSDGGLASLMIALYLTQDSFGTACNVSGDNAIAVVVDKINDGMS
                     KKGNKEEQSA"
     gene            complement(9643..10719)
                     /locus_tag="KNP36_003110"
     CDS             complement(9643..10719)
                     /locus_tag="KNP36_003110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003415975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HBF0874960.1"
                     /translation="MSTNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIV
                     NNIDMVSMYPDPDYIDLKTSISNYCKCSIDNIVLGSGATELISSFIHTINPKQALLLS
                     PAYSEYEKELSKINCSIEKYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGF
                     AFTKVEVREILKNTDSFLMIDETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTP
                     GIRLGYGLISNTNVKNEINKNLDLWNINIIASKMGEIMFSDLDFISNTISLMNTERDY
                     LLKELKNIKSLDIYNTKGNFILCKIKTKELTAKSLREQLLPQKIIIRDCCSFEGLDEY
                     FFRVCILKPNENKLLISSLKAIFK"
     gene            10948..11475
                     /gene="hpt"
                     /locus_tag="KNP36_003111"
     CDS             10948..11475
                     /gene="hpt"
                     /locus_tag="KNP36_003111"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HBF0874961.1"
                     /translation="MYKVTGKMLTEEQIKEKVYELGKKIEEDFKGEDLLVVGILKGAS
                     VFVSDLIRCIDLDVNIDFMSVTSYGNSTESSGTVKILKDLDVDIEGKNVLIVEDIIDS
                     GLTLSNLVAALKTRNPKSLKLCTLLDKPQRRKANIPVDYVGFVIEDKFIVGYGIDYAE
                     KYRNLPYIGIVEDVE"
     gene            11564..12496
                     /locus_tag="KNP36_003112"
     CDS             11564..12496
                     /locus_tag="KNP36_003112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HBF0874962.1"
                     /translation="MDIQLNILLFFQNLRNPILNFIFLVFTISTEAPLLILITTIIYW
                     CINKKCGQKILFAIIGNFVVNLGIKEFVKAPRPIGIKGLESLRVSTAGGYSFPSAHTQ
                     TATTFWVSIMTIFKKRYLHLIGAVMVLGVGLSRLYLAVHWPIDVIAGWILGIFFTVVF
                     VKIFDYIDDNKNYILLVVLLIPFIIVAIFLNSPEYFEKFGIIVGFVFGYMVEDRFVKF
                     NTDNNNKKINFSNKNKGSKNIIFSRICRFLVGIVTIGMLYIGIKLFISMLIVTLNISD
                     STMSIIFMNFIKNTVVVFYGIAGAPALFKLLKLN"
     gene            12558..13784
                     /locus_tag="KNP36_003113"
     CDS             12558..13784
                     /locus_tag="KNP36_003113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HBF0874963.1"
                     /translation="MKKVVIIGGGPAGMIAASTACEKGYDVTLIEKNHKLGKKLAITG
                     KGRCNITNACEIEELIENVPTNGKFLYSAFYTFTNDDVISMFNNLGVKTKTERGKRVF
                     PESDKAFDIVNALERQLKSKKVNILLNSKVEKIISKNNKIEKVILNDKKEIKCDSVVV
                     ATGGLSYPLTGSTGDGYKFAISQGHTIIDTKPSLIGIEVQESFTKDLEKLSLRNVEIR
                     VFNSKQKKVYSDFGELEFTKFGLDGPIIKSASCRMKDTRKENYTILLDLKPALDEEKL
                     DKRVQKDFQKYTNKKFEKALDDLLPKKLIPIIINLSEINPNTVVHQISREQRKNLVHL
                     LKNLKFTVKRYRPIEEAIITSGGVKVNEINSSTMESKLVEGLFFAGEVIDIDAYTGGF
                     NLQIAFSTGYLAGFNC"
     gene            13868..14089
                     /locus_tag="KNP36_003114"
     CDS             13868..14089
                     /locus_tag="KNP36_003114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000002841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta-type small acid-soluble spore
                     protein"
                     /protein_id="HBF0874964.1"
                     /translation="MASNNNNNRTVVPGAKEALNQMKLEIANELGMSNYQQVDKGNLT
                     ARENGYVGGYMTKKLVEMAEQQMAGKSNR"
BASE COUNT         5334 a         1561 c         2420 g         4828 t
ORIGIN      
        1 agtaaagatg aattactata ggtttaaatt atattatttt ctattatttt tatgcctttc
       61 tcagttattg atgagccttt tcttccctta ctagaaatta agtatccatt gcgtgtcaaa
      121 tattctagca tatttcttac ttcgtattct gtgacattat attccataaa tttcattaac
      181 tttgtcctcc ccattggttt catgtgcaat gattttagga tagaaatgca tatgtttttg
      241 tcatattggt ttaaatcatt gaatatggac atattacttg acatatgatt attatttaat
      301 tttgaagata tgttttgagg taaatcattt attgtaagat aattggaacc catgtaagcc
      361 atatattcaa cacaatttct cagttctcta atattcccca tccaagtgta tgaatttaaa
      421 gcttctaaaa gactcttatc gagttttatg tttttatagg gaagttcttt taaaaatgat
      481 tctaaaagaa gaggtatatc ttctaatctc tttctaagag gaggtaaatc taaagtgaac
      541 atacttatcc tataaaataa atccatccta aatttatttt ctataattaa tttctctaaa
      601 tctttatttg tggcagctaa tattctcaca tcaattggaa taatacttgt accaccaatt
      661 tttctaattt ctttttcttg taagactctt aaaagtttaa cctgtaaatc atgtggcata
      721 tctcctatct catctaaaaa tatagtgcca gtatgagcta attcgaataa tccttttttt
      781 ccaccttttt ttgctccagt aaaagaacca tcttcatatc caaatagttc actttcaagt
      841 aattcacttg gtaatgaagc acaatttatt gctacaaaag gtttattttt tctatttgaa
      901 tgattgtgta ttgactgagt aaaggcttct ttacctgttc ctgtttcacc tgttattaat
      961 ataggattat ctgtaagagc catttttttt gcctttttaa tacaatcttt tataatagaa
     1021 ctatttccaa taatattatt aaatttatat ttagctacat aacctctttt gacagaatca
     1081 cttcttattt tttgttctaa tatttctata ttgtttacat cttttaatgt aattaagcaa
     1141 ccctctatat ttttataaag ataaaatggt tttttagaaa gtatgaattt tttatctatt
     1201 tcgtctatgt atataatcat attatctata tttaagttct ttgtaatttt atctaagaaa
     1261 ctctttggca tatattccat taaggaaggt gattttataa gtttttcatc tagttccaac
     1321 atattaagta aagacttatt tacaaaagta accttattaa aggtattgaa aaatattaga
     1381 ccatcaccta tttcatcaat ggtcatgtaa agtatagttt ttaatttaga tatattatct
     1441 aatgatgtat ttaagaaatc atgacttagt gtctccttgg acaatttgta taatttttct
     1501 ataaatttct cattttttag ttttaatact actaataatg acatatatgt atctaatgag
     1561 atttttctcc aacctaaatc aacaatattt tttatgtatt ttggtataaa tctaatctga
     1621 cctggtgtta tagctgtatc taaatcatat atttcatcac aatctggata tgtcggtaca
     1681 aaatctatat gatttatacc aattttatat agataagtag ccatctcaaa tgctgaagtt
     1741 ttattggttg tcataagtaa cgattttgta cctggaggca gtttcatcat tttttcatat
     1801 ccaagttttg aaagtgcttt cgttccatga ataatttcaa tatcttcctt aaaatgtttt
     1861 attaaaaaat tactagttaa aggtgataga gaaagcacta catctccctc taaattttct
     1921 tttattccat caagtatatt ttgtgtttct atgattattt cgtctccaaa aaagtttgtt
     1981 aattcttctt tgtagtggtc actattcaat ttatcatatg ttataaggat taacttcttt
     2041 ttatccattt tatttctcct aacaaaatag tatttatttt taaagtattt aaagtataag
     2101 gcaagttata ttatacaaca aatagtagta taaatttata tatttgatta aataataggt
     2161 ttttttagga ttttatccta taaaaaccta ttttgaaatt atttttgcaa gataaggaaa
     2221 atagcttttt atattgtaat gtatatttta aataattaat aaaaaaatat tatattttta
     2281 aacttgaaaa gtaagtaatt ataagctatt taatcactgg aataaattta caataaaaaa
     2341 ataaatacaa aggctttatc attaaggtat tggcataagt tttgcttatt aaacaagtat
     2401 actaataaaa ttcatttaaa caggagggag aatttatatg agtaaattag aatcaacaac
     2461 agaaaaagtt gaggtaaaat ggtatgggta tgtagcatta atattgggag cattattttt
     2521 ttcaggaata tttaaagatg caccaggacc attaaaagta ttggatttta acaatgtatt
     2581 aggttctttt ggaacattgg gaacaattaa tgatggtgta ggtacattag ctgcaaactt
     2641 tagaggtgat ggaggtactg gccctcgaga tggatggcta tatgcattga cattaatacc
     2701 atcagttatg tttgcacttg gagtagttag agttatagac cacttagatg gaatgaaggc
     2761 agctcaaaag cttcttagtc cactattaaa gccattatta gggttacctg gatttgcagg
     2821 actaactttg atagctagtt tacagtctac agatgcagct gcatctatga ctaaagaact
     2881 taaagatgat gggtatatag atgaaaaaca aaaagctgta ttttgtgcat ttcaattttc
     2941 aggtgcgtct gcaattacga atttctttgc ttctggagca gcactatttc catttatagg
     3001 agatgtacca atatttatac cacttgcttt aatattaatt atgaagtttg ttggggcgaa
     3061 cttacttaga ttatatttaa ataaatttga caagggggaa gcttaacatg agtgaggtag
     3121 caaaaaaaga agtaaaagtt aaaaaaggaa atgtgataga tgcgtttatt ggaggagcta
     3181 gaaatggatt ccaaataagt acaaattcaa tggctccaaa tgtcatcttc ggttttgcta
     3241 taatttctgt gttcaactta acaggtcttt tggatgtaat agggacaata tttacacctg
     3301 taatgagtat ctttggactt ccaggtgttg cagcaacagc tataatgaca atatttatat
     3361 caatgggagg agcatctgga gtaatcgcag gtttatttac agcaggtcaa ataagtcaag
     3421 cacatgttgc aattctattg ccaatgttat tgctttcagg agcgcagata caatttatgg
     3481 ggagactttt aggaacagct gagttaaaaa ctaaatatta tccacatatg tttgttatag
     3541 caactttaaa tggttgtatt gcaatgctta taatgaatta tttcgtagta taggtaatta
     3601 taataaaaat ttaatataaa tggaaagttt aaattttaag gaggagctag attatgggaa
     3661 ctaacaaaga ttatattgag tatgtacata aagtgtatga ttatctacac actataccag
     3721 aaaaaggatt tgaagaatat aagacatcag agtttgtttt aaaagagctt gaaaaaatgg
     3781 ggtttgaaaa tattaataaa ggagttgcag gaactggtat tatagtaact atagattcta
     3841 aaaaagaagg accagtattt gctataagag cagatatgga tgcattggaa tttatcatag
     3901 atggagaaaa gaaaatgata catgcttgtg gtcatgatgg tcatacttct atgcttttaa
     3961 cagctgcaaa gttaataaaa gagagaaatt tagtaaaaag aggtaagtta aaaatacttt
     4021 ttcaaccagg tgaagaaaaa ttatatggag cattaagagt aattgattct ggtttgttgg
     4081 atgatgtaga agaaatggta gggatgcatt taagacctgg acaagattgt aggttgggaa
     4141 aggcgatacc tgcaatgtac cattgtgcta gctgtataat ggaatttacg attaaaggta
     4201 tcacttgtca tggttctaaa ccacatttag gagtaaatgc agtagatgct gtctgtttag
     4261 cagtgaatgc aataaatgca ataagagtaa atccagctat accaaattct ataaaagtaa
     4321 caaatatatc agttaaggga gaaacttata ataatatacc agatgaagca tttatggctt
     4381 tagatataag ggcagaaagt aatgatataa tagaagaatt aaaagaaaaa gcaatacatg
     4441 ctgtaaaaac tgttgtaagt tctataaatg cagaagctgt actaatttcc aaagatggag
     4501 taccagcagc agaatttgat gaagaacttg taaacttggc tgaagaaact ataaaagatg
     4561 tattgggagc tgatgcatct ataggtatat ttaaaaattc tggtggagaa gacttccatt
     4621 attatacaca aaaactaaaa tgtaaaacta catatattgg attaggagct gatgctacac
     4681 caggatttca taatccaaat gtaacatttg atacgaaagc tttagaatat ggtgtagata
     4741 tatggtgtag attggttgaa aagagattgg gataacatcc aaactaataa ttctacattt
     4801 aaaattataa ttatagaagt tatagaaaaa gattgcttat gttaattaga aaataattaa
     4861 tatgagcaat cttattttga tataatgaaa ctgattttgg aatattgaaa aaatatgatg
     4921 gaaaagtaat tatattttaa atctattgga caaaaaagtg atattattat aatattaaga
     4981 attgtaaaat aataccaaag tgcatctagt aatagactta acaattataa aaattttatt
     5041 cttaggaggg aaaaaatgag taagtataat tttgacagag taatagatag agtaggaaca
     5101 gattgtgtaa aatgggattt tagaactaat tgttcaacaa aagcacaaaa agatggtttg
     5161 cctttttgga ttgctgatat ggattttgaa tgtgcagaac caataataga agcattacgt
     5221 aaaaaagttg aacataaaat atttggatat agttcaaatg atagtgataa atactttaat
     5281 gcagtttgtg attggtataa aaggagattt aactgggaaa taagtagaaa agatattatt
     5341 tttagtcctg gtgttgtacc tgctgttgct attttagtaa gaatattaac taattctaat
     5401 gaaggtgtaa tagtccaaaa accagtgtat tacccatttg aagctaagat aaagagcaat
     5461 aatagggacg ttgtaaacaa tcctctgata tatgagaatg gtacttatag gatggattat
     5521 gatgatttag aagaaaaagc taagtgtagc aacaataaag tactaatact ttgtagtcct
     5581 cacaaccctg ttggaagagt ttggagagaa gatgaattaa aaaaggttgt agaaatatgt
     5641 aaaaaatatg acctatggat aatagctgat gagatacatt ctgatttaat tagaaaagga
     5701 tttaaacata ctcctttaca gtcattatgc ccagagtaca aggataaaat agttacatgt
     5761 atagctccaa gtaaaacatt taatctggca ggaatgcagt tgtctaatat aatagtgaat
     5821 aatgatgaac taaaaaagaa atatcaagaa gaggttacag ctgttggagt tgcaacttca
     5881 ccaaatccct ttgctattgt agctacaata gcagcatata atgaaagtga agactggctt
     5941 aatgaattaa atgattactt agataataat atacaattta ttgatgaata cttaaaagaa
     6001 aacctaccaa aagtaaaact tgtttatcca gaaggaacat atctagcatg gttagatttt
     6061 actgcttatg gattaaatga agtagaactt gaagatttaa tgtttaaaaa agctaatgta
     6121 ttatttgatg aaggttatat atttggaaaa gaaggaatag gatttgaaag aataaatgta
     6181 gcttgtccac agtctttatt aaaagaatgt atggacagat taaagactat atttgaaaat
     6241 ttataaagta taggtaaaaa tttataaagt gtttaaaaat aaaaaaataa taaacttgac
     6301 aaattttaac taatcactta tcatactatt atgaataaat agaaaacata agagagctaa
     6361 attttattga attaaactct taaagacttt gaaaggaaga gtagttatag aatgtaatta
     6421 aagcgagttg gtgatggtgt gagaccaata tgaagtctat agtgaagaac atcctggagt
     6481 tgctaaccga aattttaaaa gagtaggctt agtcggaacc aaaccgttat catattgggg
     6541 tgtatcgagt aatatctgta cattgtgagc tgggtttgaa tttatttcaa actaatcagg
     6601 gtggtaccgc ggaaaagcaa cctttcgtcc cttttatata gggatgaagg gtttttttaa
     6661 tggaaaaata tataaatata gggagtgaat gatatgagca caataatacc aaaggattat
     6721 aaaagtagtt tgaacgtaat tgatacacaa atagctataa aaaaattaaa agattttttt
     6781 gaaatgagac taagtaatga attaaatctt ataagagttt cttctccgtt atttgtattg
     6841 ccagaaacag gtgcaaatga taatttaaat ggagaaaagg ctgtaagctt tgatatacca
     6901 tttatgaata aaaatgcaga aattgttcaa tcacttgcaa aatggaaaag attagccctt
     6961 aaaaaatatg ggtttgaagt tggtagtggt ttatatacag atatgaatgc aataagaaaa
     7021 aatgaagaat tagacaatat acattctctt tatgtagacc aatgggattg ggaattggtt
     7081 atagataaaa gtagtagaaa tgaaaagact ctaaaagatg ttgtaaaaag attgtatgga
     7141 gtatttaaag atactgaaat ttttgtatgt agtatgtatg aaggtataaa agaaatatta
     7201 ccagaagaaa taacttttat aacatcacaa gagttagaag atatgtatcc agaattatca
     7261 ccaaaggaaa gagaagataa aattgtaaaa gagaagaaag cagtatttat aactcaaata
     7321 ggaaaaacat taatatcagg agaaaaacat gatggaagaa gtcctgatta tgatgattgg
     7381 gaattgaatg gggatatatt attttacaat cctgttttag attcagcatt agaattatct
     7441 tcaatgggaa ttagagttga tgaagaatct cttgatagac aattgaaact tgctggatgt
     7501 gaagagagaa aagagtttga ctatcataag atgcttttaa atggcgaact tccgtataca
     7561 attggtggag gaattggtca gtcaagaata tgtatgtatt tcttacaaaa agctcatata
     7621 ggagaagtac aagttggagt atggccacag gatatgattc aaaattgtag tagtgcagga
     7681 attgaattat tataatttaa atataaacta attgataaaa tttatatcta atatgttcat
     7741 caaattaatt atatcggtta taatgtagaa taacctataa ttataagagg tgataaatat
     7801 ggagttttta aaaataatca ttaatatagt tttagatatt ttaaaaaaaa ttttggtcag
     7861 atttaaaaat gctaaatttg gtttggtttt tgtatttgat ttacttaaac tacctgattt
     7921 tatgacagat aaaagaatca atatagttga taaaataaag gtaatttctg tattaatttt
     7981 tactatatcc tactttgtat ctggggttga tataattcca gagatgattg caggggcatt
     8041 tggttttata gatgatgcta tagttttaat ttggagtata ggtatagtga atgaagaaat
     8101 taataagtat agagttatcg caaaaaaaga taaacattca aatataattg aaaatgtaga
     8161 attttctata aaagatgaag aagaataaca atttatatat gttattcttt tttttattaa
     8221 caaaaaatgg ttaaattgtt gacggagagg taaaactcta ttatcataat aagtggatat
     8281 ccaatattta actaagtatt caatgtgcaa gaatgcttaa tttaaaaaag ttatggaggg
     8341 taaatattat gaagaaaaaa ataggtttag tgcccaaact aatcatcggt atcatagtcg
     8401 gtattttaat cggaagttat gcaccagaaa taatagtaca aatattagta acagttagta
     8461 ctttattctc agcattccta aaatttgtta taccatttat aattataggt tttgtaacag
     8521 caggtatagc tgatttagca acaggtgcag gaaagttatt ggggataact acgggaatag
     8581 catatggttc taccttaata gcaggattat tatcatttgc agtatctaca ttaatcttcc
     8641 caaattttat tgatgcaagt gttgcaagtc aaattggaga cccagaggca ggaatgttag
     8701 ctccaatatt cacaattcca ttagagccta tggtagatgt aacagctgca atcgtatttg
     8761 catttgtaat gggacttgga atatcagctt taagaaatca tggaaaagga gagactttat
     8821 ttaatttctt ccaagaattt caaggaatcg taacgaaaac gttgtcaaca gtgattatac
     8881 ctttattacc tttatacata gcaggaactt ttgcaaatat aactatagca ggggaagtat
     8941 ggacaatatt aggggtattc tggaaagtat acttagtagt aataccttta cattttgtat
     9001 atatggcatg tcaattcaca gcagcaggtg tattttcagg aaaaaatcca gtaagaatgt
     9061 taaaaaatca agtacctgga tatttaacag ctataggaac tcaatcttca gcagcaacta
     9121 taccagttaa tgttggttgt gcagaaaaaa atggagtaag taagcaaata agagaatttg
     9181 ttgtacctct ttgtgcaaca atacatttat caggtagtat gatatcaata acaggattta
     9241 caactgcagt tttaatgatg aatggtatgc cacatggaat aggtgtatta ttcccttata
     9301 ttgcaatgtt aggtatagca atggttgcag caccaggagc accaggtggg gctataatga
     9361 gtgcacttcc tttcctacca atggttggaa taccatcaga tggtgggctt gcaagtttaa
     9421 tgatagcttt atacttaact caagacagtt ttggtacagc atgtaatgta tcaggagata
     9481 atgcaatagc agtagtagta gataaaataa atgatggaat gagtaaaaaa ggaaataaag
     9541 aagagcaaag tgcttagttt tttaataatc aaaaatgagt tatctcaaat agagatagct
     9601 cattttttat ggtataaaaa attataaaat aaagtgattt ttttatttaa aaattgcttt
     9661 aagagatgat attaataatt tattttcatt aggttttaat atacatactc taaagaaata
     9721 ctcatctaga ccttcaaatg aacaacaatc tcttattatt attttttgtg gaagcagttg
     9781 ctctcgaaga gatttagcag tcaattcctt tgtcttgatt ttacacaata tgaaattacc
     9841 tttagtattg tatatatcta agctttttat attcttaagc tctttaagca ggtaatctct
     9901 ttcagtgttc attaaggaaa tagtatttga tataaaatct aaatcactaa acatgatttc
     9961 acccatttta gaagctatta tgtttatatt ccataaatct agatttttat ttatttcatt
    10021 tttgacatta gtgttagata taagaccata tccaagcctt attccaggcg ttgaaaaaaa
    10081 ttttgatgta cctcttataa cgaataaatt agaataatca tcaactaatt gagtacaaga
    10141 gtatgtatct gtatcagtaa actctacata agtctcatca atcattaaaa atgagtctgt
    10201 attttttaaa atttctctca cttctacttt agtaaatgca aatccagttg gattactagg
    10261 attacagatt actaccaaat cataatcttt agcattgata gtttttataa gattttctaa
    10321 atttatatga aaattatctt cttcttttgc aaagtatttt tctatagaac aattaatttt
    10381 agataactct ttttcatact ctgaataggc tggagagagt aaaagagcct gtttagggtt
    10441 aattgtatgt ataaatgatg aaattagttc tgtagctcca ctgccaagta ctatattatc
    10501 tatagaacat ttgcagtaat tggatataga agtttttaag tctatgtaat cagggtcagg
    10561 atacatagat accatatcta tattgtttac aatgtattgt ttggctaaac ttgatgtacc
    10621 aaaaggattt atatttgagc taaaatccat aaattcttcc tttgaaaagc catacttact
    10681 agataaacta tataaattag ctccatggtt tgtgctcata aaagtacctc caaaaataaa
    10741 attatataat cgataaaaat aactgattaa tatatgtaca tatagattat aatacaaagg
    10801 aatcgttatt ccaaattttt aatgtaaaaa gcaaaaaagt atggataagc tgttaattta
    10861 ggtttaaaaa tgatgaaaaa gattttaatt gatattttgg tatgctataa tatataagtt
    10921 aatagaagga aagcgggagg atacaaaatg tacaaagtta caggaaaaat gttgacagaa
    10981 gaacaaataa aagaaaaagt ttatgaatta ggaaaaaaga tagaagaaga ctttaaaggc
    11041 gaagatttac tagtggtagg tatacttaaa ggagctagtg tatttgtttc agatttaata
    11101 agatgtatag atttggatgt aaatatagat tttatgagtg ttacaagtta tggaaactca
    11161 acagagtctt ctggaacagt taaaatatta aaagatttag atgtagatat tgaaggaaag
    11221 aatgtgttga ttgtagagga tataatagat tctggtttaa cattaagtaa tctagttgca
    11281 gctttaaaaa ctagaaatcc aaaatcttta aaactatgta ctctacttga taaacctcag
    11341 agaagaaaag ctaatatacc tgtagactat gttggatttg ttatagaaga caaatttatt
    11401 gttggttatg gaatagacta tgctgaaaag tatagaaatt taccttatat aggtatagtt
    11461 gaggatgtag aatagattta aatgtgaatc aaaagcacta atttctaagg gagttagtgc
    11521 tttttagtta attatataaa attttagtaa aggagacatc tatatggata ttcagttaaa
    11581 tatattatta tttttccaaa atttaagaaa tccaattttg aactttatat ttcttgtctt
    11641 tacaataagc acagaagcac cgttattaat attaattaca acaattatat actggtgtat
    11701 aaataaaaaa tgtggacaga aaatactgtt tgctataatt ggaaattttg ttgtaaattt
    11761 aggcatcaaa gagtttgtaa aagctcccag accaatagga ataaaaggtc ttgaatcatt
    11821 gagagtttct actgctggtg gttattcttt tccaagtgct catactcaaa ctgcaacaac
    11881 attttgggtt agtattatga ctatatttaa aaagagatat cttcatttaa taggtgcagt
    11941 tatggtttta ggagtaggat tgtctaggct gtatttagct gttcattggc caatagatgt
    12001 gatagcgggt tggatattag gaatattttt tacagttgta tttgtaaaaa tatttgacta
    12061 tattgatgat aataaaaatt atattttact tgtagtttta cttataccat ttataatagt
    12121 ggctatattt ctaaatagcc ctgaatattt tgaaaaattt ggtataatag taggatttgt
    12181 atttggatat atggttgagg atagatttgt taaatttaat acagataata ataacaaaaa
    12241 aataaatttt agcaataaaa ataaggggag taaaaatata attttttcaa gaatatgtag
    12301 gtttttggtt gggatagtaa caataggaat gttatatatt ggcattaagt tgtttatttc
    12361 aatgttaata gtcactttaa atataagtga ctctactatg agtataattt ttatgaattt
    12421 tattaagaat acagtagttg ttttttatgg aatagcagga gctccagcat tatttaaact
    12481 tttaaaatta aattgatttt aaggtataga gtcaatagtt taaattaaaa aaattaaggg
    12541 tagaaaagag tgattatttg aagaaggtag taataatagg tggtggacca gcagggatga
    12601 tagccgcatc aactgcatgt gagaaaggct atgatgtaac attaattgag aaaaatcata
    12661 aattaggaaa aaaacttgca ataacaggaa aaggtagatg taatattact aacgcttgtg
    12721 aaatagagga attaatagaa aatgtaccta caaatggaaa atttctttat agtgcttttt
    12781 atacttttac aaatgatgat gtaataagta tgtttaataa tcttggagta aagactaaaa
    12841 cagaaagagg aaaaagggtt tttccagaga gtgataaagc atttgatatt gtaaatgctc
    12901 ttgaaagaca acttaaaagt aagaaagtaa atatattatt aaattcgaaa gtagaaaaaa
    12961 taatatctaa aaataataaa attgaaaaag taattttaaa cgataaaaaa gaaattaagt
    13021 gtgattcagt tgtagtagca actggtggat taagttatcc acttactggt tctactggtg
    13081 atggatataa atttgcaatt tcacaggggc acacaattat agatacaaaa ccatctttaa
    13141 ttggtataga agtacaagaa agttttacaa aagatttaga aaaattatca ttgagaaatg
    13201 ttgaaataag ggtgtttaat agcaaacaaa agaaagttta tagtgatttt ggagaacttg
    13261 aatttactaa atttggttta gatggaccta taatcaagtc tgcaagttgt agaatgaaag
    13321 atacaaggaa agaaaattac actatattat tagatttaaa acctgcatta gatgaggaaa
    13381 aattggataa aagagttcaa aaagattttc agaagtatac aaataaaaaa tttgaaaaag
    13441 cattagatga tttacttcca aaaaaactaa tacctataat aataaactta agtgaaatta
    13501 atccaaatac ggttgttcac caaatttcta gagagcagag aaaaaactta gtccatttat
    13561 taaaaaattt aaagtttaca gtaaagagat acagacctat tgaagaagct ataataactt
    13621 ctggtggtgt aaaagtaaac gaaataaatt caagtacaat ggaatcaaaa ttagtagaag
    13681 gtttattttt tgctggagaa gtaatagata tagatgcata tacaggtgga ttcaatttgc
    13741 aaatagcttt ttctactgga tatttggcag gttttaattg ctaaaaatta cctgaattaa
    13801 aaatgtttaa aatcacataa tattatcagc aacacaaaat aaattaaaca gaaggaaggt
    13861 aatcaacatg gcaagtaaca ataacaacaa cagaacagta gtaccaggag caaaagaggc
    13921 tttaaaccaa atgaaattag aaatagctaa tgaacttggt atgagtaatt atcaacaagt
    13981 tgataaagga aaccttactg caagagaaaa tggttatgta ggtggataca tgactaaaaa
    14041 attagttgaa atggctgaac aacaaatggc tggaaaaagc aacagatagt tataaataat
    14101 tatttataac tattggctat tagtttagct agagctatct caa
//
LOCUS       DAEHWM010000101        13941 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.104, whole genome shotgun sequence.
ACCESSION   DAEHWM010000101 DAEHWM010000000
VERSION     DAEHWM010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13941)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13941)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13941
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.104"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(159..1001)
                     /locus_tag="KNP36_003115"
     CDS             complement(159..1001)
                     /locus_tag="KNP36_003115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein"
                     /protein_id="HBF0874965.1"
                     /translation="MFKKKIGVLLASTMLVGALAVGCSSNSGGSGDSGDSSKVSVSGS
                     TSIGPLMETIGEKFQEKNQGVSVEVQQIGSSGGIKNAIEGTSEIGMSSRDLKDEEKSA
                     GLKETKIAIDGIALITNTANSVKNLTMDQVKGIYTGKITNWKEVGGNDAPIVIVSREE
                     GSGTRDGFQEIVGFDSEELTKDAQISDGSGNIKTTVEGNENAIGYISFGYVDEKVNSL
                     KINDVEATDANVIANKYPISRPFILVNKEDGLSEKGKALIDYILSDEGQALVSEKGFI
                     KVNQ"
     gene            complement(1253..3037)
                     /gene="pepF"
                     /locus_tag="KNP36_003116"
     CDS             complement(1253..3037)
                     /gene="pepF"
                     /locus_tag="KNP36_003116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HBF0874966.1"
                     /translation="MGTDRSTIEEKYKWKIDKMYSSKEEIEKDISKVKNLIQEVKEYK
                     GKLSESKENLYKVLNISENASRIVQNLYVYTHMKQHEDTRINDNQGRATKTEMLSTDL
                     GVATSYIVPEILAIEENKLSEYLKDEKLSFYAKYIKDILRDKPHTLSEREEEILAATS
                     ELSTIPENVYDMLAYADMEFPEIEDEEGNKVKLSHSNYSLFIKSKNSRVRKDAFEGEF
                     STYEKYKNTFASTLYGGIKSEIFYAKTRKYNSAIEASLFSDDVSLDVYNNLISAIDKS
                     IPNLNKYVELKKKFLGLNEIHMYDLYVPLTDKFDMDIPYDKAQDIILEALKPLGEEYL
                     KVIKSAFDEGWIDVYDNEGKKGGAYSWGSYDSHPYILMSYKNDLNSLFTLIHELGHSV
                     HSHYSRTSQPFLYSDYKIFVAEVASTLNELLLINYLLENSKSKDETIYLLNYYLEQFR
                     TTVHRQTMFAEFEKIVHQRVESGEPLTADEFTNIYYKLNEKYYGKSAIVDKQIGIEWA
                     RIPHFYSNFYVYKYATGFSAASALSQQILSEGSTAVDRYINFLKSGGSEYPLEQLKSA
                     GVDMTKKESIEEALNVFAELVNKLEKEL"
     gene            complement(3103..3768)
                     /locus_tag="KNP36_003117"
     CDS             complement(3103..3768)
                     /locus_tag="KNP36_003117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBF0874967.1"
                     /translation="MIDIGSKEIAIRLLLALIIGGIIGLEREKIRQFAGFRTHILIAI
                     GSCIVSITSIQLFFDYNLYTNADPARMPAQVLSGIGFLGAGAILKNKGGVKGLTTAAG
                     MWATACIGIAVGYGYYELAILGGLFVMIALFVLRIINTFLFSQEKNVLILKLSNLDSI
                     PFLYDKFEKNQLIVRNMEIECRNEEYWKVNFFVSYAKRIHLHDVMKEINMIEGVINVD
                     YLD"
     gene            complement(3919..4080)
                     /locus_tag="KNP36_003118"
     CDS             complement(3919..4080)
                     /locus_tag="KNP36_003118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="HBF0874968.1"
                     /translation="MANNELEALKNEIEAVREEINTYIEYPEIFQEELVESSKKIDIL
                     INKYMYLSK"
     gene            complement(4158..4667)
                     /locus_tag="KNP36_003119"
     CDS             complement(4158..4667)
                     /locus_tag="KNP36_003119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gx transporter family protein"
                     /protein_id="HBF0874969.1"
                     /translation="MKTRKMTFLGLMIGYSLALYVLETYIPNPLIVIFPGAKLGLSNI
                     ITLISLMLLGVKDTVIIVTIRVILSSIFAGPLSYLLFSIGGAYLSLLFMYLASKIKDL
                     SLIGISIIGAIGHNIGQLIVASLIIENILAIGYLPFMLMASLVTGMFVGLVSRYTIPK
                     LKHFYSKFY"
     gene            4873..5091
                     /locus_tag="KNP36_003120"
     CDS             4873..5091
                     /locus_tag="KNP36_003120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein A"
                     /protein_id="HBF0874970.1"
                     /translation="MTVYDLKIGEKGFINSIDGDIKLSKRLLALGCINSTEIEVKKVA
                     PLGDPIIIRFRGFDLAIRKSDAKNISLQ"
     gene            5109..7055
                     /gene="feoB"
                     /locus_tag="KNP36_003121"
     CDS             5109..7055
                     /gene="feoB"
                     /locus_tag="KNP36_003121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrous iron transport protein B"
                     /protein_id="HBF0874971.1"
                     /translation="MINVALLGNPNVGKTTVFNLLTGSNQYVGNWPGVTIEKKEGFLG
                     KEIKVVDLPGIYAMDTFSNEEKVSKSYLENEDVDVIVNVVDASNLSRNLYLTTQLMQF
                     NKPIVILLNMLDIAESKGVNIDAKKLSEELGVIVVPIIAKKKNGVDRIEEEIKGATQK
                     AFIYQKNFGSETETYKKLESILSRCTKTTYTQKKSISDKIDNIVLNPILAYPIFIGVL
                     FLLFKFTFDWVGGPLQEGFASLIEAYISAPVSDMLSNSSPWFKSLIVDGIIGGVGGTL
                     PFFPLIFTLFFGISLFEDSGYMSRTAFLMDKVMRKVGLSGKAFIPIVMGMGCSSPAIM
                     ATRTLESEKDRRVTALIAPLMTCGAKLPIYALFVAIFFPHNAALVTTSLYLVGIVMAI
                     VVALFLNKTAFKTEAEPFILELPEYRIPTIDALIKNTWNKSKGFLIRVVTVMFAMSVV
                     IWGLSSFNVFGYTEDINVSFLATLGHIISPIFKPLGFDDWRTSVAILSGLGAKEIVVN
                     SLNILYGNLTVVLPTIFNGVTAYTFLIFTALYTPCIAALATMKKEYGNKMMFTSFAYQ
                     FILAWIMAFIVKSIGGVLFMGNSIIEALIGGIIIVLALFILFNKFKSTKNGNVCSGCS
                     ICSGCPSANSCSSKEDSNKKNNAH"
     gene            complement(7234..8289)
                     /locus_tag="KNP36_003122"
     CDS             complement(7234..8289)
                     /locus_tag="KNP36_003122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBF0874972.1"
                     /translation="MTIQDYMLETPVRMREIISNADSLFNEVKRTNLKKIIITGSGTS
                     YHSGVQVQPYLQNLLDIDVVKMYPFMITEDTFKFDNENTLVVGVSQGGSSYSTYNAMK
                     LAEDKGCKIASMAGCKNALIDEISDYILTVNCGEEKSGAKTKGYYCTKLNLMLLGLQI
                     AREKGIISSEKYNEEINKILDAINRFEAVYKLSKQWIERNKEKLVNSKEIRIIGHSDI
                     YGDTLEAALKLLETMRIPVTGYEFEEFIHGIYNAINSDSTIFILDTGKEPRVTKMIDV
                     LSGWTENVFAIGRDVTENDKNLKIDITDNPYYQTFNFIVPIQLICGEIPTLRGVDPSV
                     PKDTRFHMKLGSKKLNK"
     gene            complement(8337..9137)
                     /locus_tag="KNP36_003123"
     CDS             complement(8337..9137)
                     /locus_tag="KNP36_003123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HBF0874973.1"
                     /translation="MNKLTKKELRSMFWRSFALQGAFNYERMQNLGYCYSMLPAIKKL
                     YNKKENQAKAIERHLEIFNTTTVVVPAILGITAAMEEENANNPEFDESSISAVKTALM
                     GPLAGIGDSLFWGTFRIIAAGVGVSLAKEGNIFGPLLFLLLYNIPAFALRIFGLKYGY
                     QVGVNSLERIQREGLMEKIMSMATTVGLFVVGGMVATMLSITTPLKFNLNGAEVILQD
                     ILDKIIPNMLPLTFAFVIYYMLKRKVSVTKLTIGTIVTGIALHAIGLL"
     gene            complement(9130..9921)
                     /locus_tag="KNP36_003124"
     CDS             complement(9130..9921)
                     /locus_tag="KNP36_003124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0874974.1"
                     /translation="MLVQATMLAIIAGVGILDGRIFGQSMLDRPIVTGMLVGLVLGDI
                     KSGIMIGAQLELIWMGIAGIGAATPPDVVTGGVLGTAFAILSGNGAEVALAVAVPVAV
                     LAQSLGVLVRIINSYFSQKAVFYAKQADFKKVTIMMWLPVILFFLSTSVPTFLAIMIG
                     ADKVTALINAIPKVILDGLGVAGTLLPAVGFALLMDMLLSKKMSVFFFIGFLLASYGG
                     LDITAIALFGVCVAFVLNFYINNKENNQNPQLAINTLTEGEIDFE"
     gene            complement(9961..10383)
                     /locus_tag="KNP36_003125"
     CDS             complement(9961..10383)
                     /locus_tag="KNP36_003125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIA"
                     /protein_id="HBF0874975.1"
                     /translation="MKKFLIATHGELSRELVDTSKLIIGSLTNIEYFCMTTDKSADDA
                     EKEIRSILSNNKDSEEFVVLTDVFGGSVANICTNLLLQGFKFELLTGVNLPMLLSILL
                     LVEEDTKLIVKSGLEEAKNGIVYVNELLENQNKIKNVM"
     gene            complement(10399..10878)
                     /locus_tag="KNP36_003126"
     CDS             complement(10399..10878)
                     /locus_tag="KNP36_003126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0874976.1"
                     /translation="MVSLMRIDDRLIHGQVAYGWATSLGINVILVANDEAKNDQMKAM
                     SLNLAKPSNVTLYIRGVEESGEIVEKFASSKKSNVLVLVKNTKDALVVAKNSGGVLKE
                     INVGGLRYEEGKKKLTDLVAVDDDDINNFKQIGDLGIDIEFRMLPRDKKKQLSDLIK"
     gene            complement(11010..13766)
                     /locus_tag="KNP36_003127"
     CDS             complement(11010..13766)
                     /locus_tag="KNP36_003127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0874977.1"
                     /translation="MRDEILSFVNECVLFNNFDELKKESGIITEDIVKKFNLSRTQSS
                     RLLNDLVKSDNLIKINSRPVIFLPKNKINDVVGPTKKSIYENLDELKNECKLLKQETV
                     FNSIIGYDNSLKEVIEQIKTAVLYPNGGLTIMLTGESGVGKTFLAKIIYKYSVSSNVL
                     EKNSPYNVLNCAQYYNNLELLSSLLFGHVKGAYTGANESRAGLIEQSDGGVLFLDEVH
                     RLNSEGQEKLFTFMDTGTFSRIGENGVIRKARVRLIFATTESLSEFLQTFLRRIPINI
                     YVPNIEERGTIEKRKIVEHFIYEESKVLGLPIEITQITLNAILKIKFKGNIGECKNVI
                     KYACGRAYAKNQRRNGNIFVTLQDLPRNLYIENVDIFQFQSGKSKSIIFSPKQFSIEM
                     SNGRNKRNIIYQSFIKCLDYFDRLEKNEITKEKFSKKSSNLMIRLMDNLVFSNNDENN
                     NVLMELIISIMQDIFRNLEVNNNIKYDGNNVLAFSSYLYLKDESYQLSDEYKALENKL
                     LIYLKKESYKEYSIISKISTLITNRLDMYLNNVDIIIMIIFIKSTIIRMKFNQVNATI
                     IAHGYATASSMANVCNRMLGKNIFTAIDMPIDATIADVSKQMSRYLEGDRIKNGLIVL
                     FDMGSLNLIYEDLKNKINSPMLFIDQISTISALEVGNLLMQGKNIEEIAEIMDEETKP
                     NIQLYYPQKNKEYAIISSCFTGIGTAIKIQHLLSESLIGIVDVKIIPYDYDSLVSMGD
                     KEPVFEMYDVMAIVGTANPNVNGVDFILLEDIISGKGEDDVFRIFSRVVENEKIKNIN
                     DSIVKNFSLIRVIDSLTILDSKKIIERIEEGINAIENIQKKKLSNDKKISLYVHLSCM
                     IERLVRQTEIEEYTDMDLLIKNHHSEVKLIKNAFSVLEKSYSVQIPISEIGYIYNIIY
                     GLPQ"
BASE COUNT         4501 a         2420 c         1597 g         5423 t
ORIGIN      
        1 ttccatattc ttagagataa gatactaaaa tacctatttt atctaaagat atttatattt
       61 ctacattcaa taatagacaa taccctgcaa gttaaagcat catttttatg agcttatctc
      121 acagggtatt atatgtttac tttatattat aactcttgtt attgattaac tttaataaat
      181 cctttttctg aaacaagtgc ttgtccttca tcacttaata tataatctat taaagcttta
      241 cctttttctg acaaaccatc ttctttatta actaatataa atggtcttga tattggatat
      301 ttattagcta ttacatttgc atcagttgct tcaacatcat ttatttttaa actatttact
      361 ttctcatcaa catatccaaa tgatatatat cctatagcat tttcatttcc ttcaactgta
      421 gtttttatat ttcctgaacc atcacttatt tgtgcatctt tagttagttc ttctgaatca
      481 aaccctacaa tttcttggaa tccatctcta gttcctgaac cttcttctct tgatactatt
      541 actattggtg catcatttcc tcctacttct ttccagttag taatctttcc tgtatatata
      601 cctttaactt ggtccattgt cagatttttt actgagtttg cagtattagt tatcaatgct
      661 ataccatcta ttgctatttt agtttccttt aatccagcac ttttttcttc atcttttaaa
      721 tctcttgaac tcattcctat ttcagatgtt ccttctatag cattttttat acctccagaa
      781 gaaccaatct gttgtacttc tacactaaca ccttgatttt tttcttgaaa cttttctccg
      841 atagtttcca taagaggacc tattgaagtt gaacctgaaa cagaaacttt gcttgaatct
      901 cctgaatcac ctgaacctcc tgagttagaa ctacatccta ctgctaaagc tccaactaac
      961 attgtactag ctaaaagaac gcctattttc tttttaaaca ttttacttac ccccgcttat
     1021 attttaattt tttgttgtca tttttctata ttttaataat acagattctt tgttaaatga
     1081 atattagagc agggttaagt aaatgtaaat attgttaaat acatgtaaaa acttaatttt
     1141 atatgattta ttcttaatta gattaacttt ttaaagttac tttaggcaga tataaacata
     1201 atacaactca tattatcaga agtcttcatt gaagctatca acctatcaca tcctataatt
     1261 ctttttctag tttattaact aattcagcaa atacatttaa ggcttcctct atagattctt
     1321 ttttcgtcat atctacacca gcagatttta attgttctag tgggtattct gaccctccac
     1381 tttttaagaa gtttatatat ctatctactg cagtacttcc ttctgaaagt atctgttgac
     1441 ttaaagcact tgcagcagaa aaccctgtgg catacttata tacatagaag tttgaataaa
     1501 aatgaggtat tctcgcccat tctattccta tttgtttatc tactattgca gattttccgt
     1561 aatacttttc atttaatttg tagtatatat tagtaaattc atcagcagta agtggttctc
     1621 cactctctac cctttgatgt acaatttttt caaattcagc aaacatagtt tgtctatgaa
     1681 ctgtagttct aaattgttct aaataataat ttaataagta tatagtttca tccttagact
     1741 tagaattttc taataaataa tttataagaa gtaattcatt taatgtagat gcaacttctg
     1801 caacgaatat cttatagtcc gaatataaaa atggttgact tgttcttgaa taatgactgt
     1861 gaacagagtg ccctaattca tgaattaaag tgaatagaga attaaggtca tttttatagc
     1921 tcattaatat ataaggatgt gaatcataac ttccccaaga ataagctcct ccttttttac
     1981 cttcattatc atatacatca atccaccctt catcaaaagc actttttatg accttcaagt
     2041 attcttctcc taaaggttta agtgcctcta atatgatatc ctgtgcttta tcatatggta
     2101 tatccatgtc aaatttatct gtcaaaggaa catacaaatc atacatgtgt atttcattca
     2161 atcctaaaaa tttcttttta agctcaacat atttatttag attaggaata cttttatcta
     2221 tagctgatat aagattattg taaacatcta aacttacatc atctgaaaat aaagacgctt
     2281 ctattgctga attatacttt ctagtttttg cgtaaaatat ctctgatttt attccaccat
     2341 aaagcgttga ggcaaatgta tttttatatt tctcatatgt tgaaaattca ccttcaaaag
     2401 cgtcttttct aactctacta ttcttacttt ttataaataa agagtagttt gaatgagaaa
     2461 gcttaacctt attcccctcc tcatcttcta tctcaggaaa ttccatatct gcatatgcta
     2521 acatatcgta tacattttct ggaattgtcg ataattctga tgtagctgca agtatttctt
     2581 cctctcgttc actcaaagta tgtggtttat ctctcaatat atcctttata tattttgcat
     2641 aaaaggatag cttctcatct tttaagtatt cacttaactt attctcttct atcgccagta
     2701 tttctggaac tatataagaa gtagccacac ctaaatcagt agataacatt tctgtcttag
     2761 tggctcttcc ttgattatca ttaattctag tatcttcatg ttgtttcata tgagtatata
     2821 catataaatt ttgaacaatc ctagatgcat tttcagagat atttaatact ttatataagt
     2881 tctccttact ctcagaaagc ttccctttat attcttttac ttcttggata agatttttta
     2941 ctttacttat gtctttttca atttcctctt tactggagta catcttatct atcttccatt
     3001 tgtacttttc ttctattgta cttctatcag ttcccatatc atacacctct attttaattt
     3061 gttttatatt ttattcactt tacaaaatat attgtatata ttttagtcca aataatctac
     3121 atttattact ccttctatca tatttatttc tttcataacg tcgtgtaagt gtattctctt
     3181 agcataagat acaaaaaaat taaccttcca gtattcttca ttacgacatt ctatttccat
     3241 atttcttacg ataagttgat ttttttcaaa tttatcatat aaaaaaggta tagaatccaa
     3301 attgcttaat tttaatatca atacattctt ttcttggcta aataaaaacg tattgattat
     3361 cctaagcaca aataatgcta tcattacaaa taatccacct agaattgcca attcataata
     3421 accatatcca actgctatac caatacatgc agttgcccac atcccagcag ctgtagtaag
     3481 cccttttact ccacctttat tttttaaaat tgctcctgca cctaaaaaac caattccaga
     3541 taatacttga gcaggcattc ttgctgggtc agcatttgta tacaaattat aatcaaagaa
     3601 taattgaatc gaagttattg aaacaataca agaacctatt gcaattagta tatgtgtcct
     3661 aaatcctgca aactgtctta ttttttctct ctctaagcct attattcctc ctattattag
     3721 tgctaatagt aaccttattg ctatctcctt acttcctata tcaatcataa tataaaaccc
     3781 tcctgactta attacaactt atgtcctaca gataatttac acatcagaaa tactatttta
     3841 tatcttaata ttattattaa tatatgtaaa atatagccat ctgttaattt ttgatacaaa
     3901 aaaacccaca actgtgggct atttgcttag gtacatgtat ttatttatta atatatctat
     3961 tttcttactt gattctacta actcttcttg aaatatttct ggatattcta tgtatgtatt
     4021 tatctcttcc ctaactgctt caatctcatt ttttaacgct tctaattcat tgttcgccat
     4081 aataatcacc actattacaa atttgtatat ttttatatac attttatcaa acaatattat
     4141 attttgtcaa tattatgtca ataaaactta ctataaaaat gctttaattt aggtattgta
     4201 tacctggata ctaagcctac aaacatacca gttactaatg atgccattaa cataaatggt
     4261 aagtacccta tagcaagtat attttctatg attaaacttg caactattaa ttgacctata
     4321 ttatgcccta ttgcacctat aatgcttatc cctattagtg ataaatcttt tattttactc
     4381 gctaaataca taaataaaag actcagataa gctcctccta tactaaatag tagatatgat
     4441 aaagggcctg caaatattga tgacaaaatt accctgatag taacaattat aacagtatct
     4501 ttgacaccta acaacattaa tgaaattaaa gttataatat tgctcaaacc caattttgcc
     4561 cctggaaata taactataag aggatttggt atatatgtct ctaatacata taaagctaaa
     4621 ctatacccta tcataagacc taaaaatgtc atttttctag ttttcattaa gttaactcct
     4681 ccaaatttta tctatcatct tacattataa tacaaaatat ataaaaacac ctaatttaga
     4741 ctaaaatatt tttaatctat ttagaataaa tattagttat ttcaatgtgc aattacctct
     4801 ataaatcttg actttttgta tcatacttgt tacaatttta atgataatga atttcattag
     4861 gaggtgttaa taatgactgt ttacgattta aaaataggag aaaaaggatt tattaatagt
     4921 atagatggag atattaaatt atctaaaaga ttgcttgcac ttggatgtat aaatagtact
     4981 gaaatagaag ttaaaaaggt tgccccactt ggagacccaa ttataattag atttagaggc
     5041 tttgaccttg cgattagaaa atctgatgct aaaaatattt ctttacaata atagaggagg
     5101 agctacccgt gattaatgta gcattattag gaaacccaaa tgtcggtaaa actactgttt
     5161 ttaatctact tacaggttca aatcaatatg taggtaactg gcctggtgtt actatagaaa
     5221 aaaaagaagg atttcttgga aaagagataa aggttgtcga tttacctggt atatatgcaa
     5281 tggatacttt ctcaaatgaa gaaaaggttt ctaaatcata tttagaaaat gaagatgttg
     5341 atgtaatagt aaatgtagtt gatgcttcta atttatcaag aaacctttac ttaacaactc
     5401 aacttatgca atttaacaag cctatagtta tattgcttaa tatgttagac attgcagaat
     5461 ctaaaggagt taatatagat gccaaaaaat taagtgaaga acttggagta attgttgttc
     5521 caattatagc aaaaaagaaa aatggtgttg ataggataga agaagagatt aagggagcta
     5581 cgcaaaaagc ttttatatat cagaaaaact ttggaagtga aacagaaaca tataaaaaat
     5641 tagaatccat tttatcgaga tgtacaaaaa ctacatatac acaaaagaaa tctatcagtg
     5701 ataagataga caatatagtc ttgaatccta tattagcata tccgatattt attggtgtat
     5761 tgttcctctt atttaaattt acctttgact gggtcggagg accactacaa gagggatttg
     5821 ctagtcttat agaggcttat atttctgcac ctgttagtga tatgttatct aactctagcc
     5881 catggtttaa atcacttata gttgatggaa taattggagg tgttggtggt actttaccat
     5941 tcttcccttt aatatttaca ttattctttg gtatatcgtt gtttgaagat agtggatata
     6001 tgtcaagaac agcattttta atggataaag ttatgagaaa ggttggtcta tctggtaaag
     6061 cttttatacc tatagttatg ggtatgggat gttcttctcc agctataatg gcaactagaa
     6121 cattggaaag cgaaaaagat agaagagtta cagctcttat tgcaccactt atgacttgtg
     6181 gagcaaagct acctatatat gcactatttg tagctatatt ctttccacat aatgctgctt
     6241 tagtaactac atcactgtat ttggtgggta tagttatggc aattgtagtt gcattattct
     6301 taaataaaac agcctttaaa acagaggctg aaccatttat attagaatta ccagaatata
     6361 gaatccctac tatagatgca cttattaaaa atacttggaa taaatcaaaa ggtttcttga
     6421 taagagttgt tactgtcatg tttgcaatgt cagtcgtaat ttggggactt tcttcattca
     6481 atgtttttgg atatacagaa gatataaatg taagcttctt ggctactcta ggtcatatta
     6541 tatctcctat attcaaacct cttggttttg atgattggag aacttcagtt gctattttaa
     6601 gtggtcttgg agcaaaagaa atcgtagtaa actctttaaa tatactatat ggtaatctaa
     6661 ctgttgtctt accaacaata tttaatggag ttactgcata tacattcttg atatttactg
     6721 ctttatatac tccatgtata gctgcacttg caactatgaa aaaagaatat ggcaataaaa
     6781 tgatgtttac atcatttgca tatcaattta tactagcatg gataatggct tttatagtta
     6841 aaagtatagg tggagtacta tttatgggta attcaataat agaagctttg ataggtggaa
     6901 taattatagt ccttgcactc tttattctgt ttaataaatt caagtctaca aaaaacggaa
     6961 atgtctgtag tggatgttct atttgttctg gatgtccaag tgctaattct tgctcaagta
     7021 aggaagacag caataaaaaa aataatgcac actaatatat aaatatttta gtttaaaata
     7081 agataaaagt gggtgtctca aaattaactt tttagttcat gaggcactct tttttataga
     7141 aaatcaaata tattttcatc atttcaacag taaaaaagag cttatctagt aaaaaagagg
     7201 cttatctcta ttttgagaca acctcttttt ttgttactta ttcagtttct tgctacctaa
     7261 cttcatgtgg aacctagtat cttttggaac acttgggtct acacctctta atgtaggtat
     7321 ttccccacat attagttgta taggtactat aaaattaaat gtttgatagt aaggattatc
     7381 tgtgatatca atctttaaat ttttatcatt ttctgtaaca tctctaccta tagcaaatac
     7441 attttccgtc caaccagaaa gtacatcaat catcttagtt actctaggtt cttttcctgt
     7501 atctagtata aatatagtag aatcactatt tatagcatta tatataccat gtataaactc
     7561 ttcaaactca tacccagtta caggtattct cattgtttcc aataatttta atgctgcttc
     7621 taatgtatct ccatatatat cagagtgacc tattattctt atttctttag aattaactaa
     7681 cttttctttg tttctttcaa tccattgttt agagagctta tacactgctt caaatctatt
     7741 aattgcgtct aatatcttat ttatttcctc attgtacttt tcactagata ttataccttt
     7801 ttctctagct atttgaagac ctaataacat taagtttaac tttgtacaat aatatccttt
     7861 tgttttagct ccagattttt cttcaccaca atttactgtt aatatataat cagaaatctc
     7921 atctattaaa gcattcttac aacctgccat agatgctatt ttacagccct tatcttcagc
     7981 taacttcata gcgttgtatg tagaataact actcccacct tgagatacac ctactactag
     8041 ggtattttca ttatcaaact tgaatgtatc ttcagttatc ataaatggat acattttcac
     8101 aacatctata tctaataaat tttgtaaata tggttgtact tgcactcctg agtgatagct
     8161 agtacctgaa cctgttatta taatcttttt tagatttgtt ctcttaactt cattaaataa
     8221 gctatctgca ttagatataa tttctctcat tctaactggt gtttctaaca tataatcttg
     8281 tattgtcatt ttatacacct tccttatcta tatattcaat aaattataat taatttctat
     8341 aacaaaccta tagcatgtaa agcgattcct gttactatag tgcctatagt taattttgtt
     8401 acacttacct ttctctttaa catgtagtat attacaaatg caaaggttaa aggtaacata
     8461 ttaggtatta ttttatctag tatatcttgt aaaattactt ctgcaccatt taagttgaat
     8521 ttcagaggag tagttatact caacatagtt gcaaccattc ctcctacaac gaataaacca
     8581 acagttgtag ccatagacat tattttctcc ataagtccct ctctttgtat tctttcaaga
     8641 gaatttaccc ctacttgata accatactta agtccaaata ttctaagggc aaatgctggt
     8701 atattgtata atagtaagaa taatagtggt ccaaagatat taccttcttt tgcaagtgat
     8761 actcctactc ctgctgctat aatcctaaat gttccccaga ataatgaatc accaattcct
     8821 gcaagaggtc ccataagagc tgttttaaca gcactaattg aactttcatc aaattctgga
     8881 ttattagcat tctcttcttc catagctgct gttataccta atatagcagg aactactact
     8941 gtcgttgtat taaaaatctc caaatgcctt tctattgctt ttgcttgatt ttctttctta
     9001 ttgtatagct tctttattgc aggtaacatt gaataacagt aacctaagtt ttgcattctt
     9061 tcgtaattaa atgcaccttg aagagcaaat gaacgccaaa acatacttct taattctttt
     9121 tttgttaatt tattcaaagt caatctctcc ttccgttaaa gtattgattg ctaattgagg
     9181 attttgatta ttttctttgt tattgatata aaagtttagt acaaatgcta cacatactcc
     9241 aaataaagct atagcagtta tatctaatcc accataagat gctaacaaaa accctataaa
     9301 gaaaaataca gacatctttt ttgaaagtaa catatccata agcaatgcaa aacctactgc
     9361 tggcaacaat gttcctgcaa cacccagtcc gtctaatata actttaggta ttgcatttat
     9421 caatgctgta actttatcag caccaatcat aattgctaaa aaggttggaa ctgatgtact
     9481 taaaaagaat aatattactg gcaaccacat cattatggta actttcttaa aatcagcttg
     9541 tttagcatag aaaactgcct tttgagaaaa gtacgaattt attattctaa ctaatactcc
     9601 aagagattgt gctaagactg ctactggtac tgctactgct aaagcaactt ctgcaccatt
     9661 acctgataat atagcaaaag ctgtacctaa tacacctcct gttactacat ctggaggagt
     9721 agctgcacct attcctgcaa ttcccatcca aattaattca agctgtgcac caatcataat
     9781 tcctgatttt atgtctccta aaactaatcc tactaacata cctgtaacta ttggcctatc
     9841 aagcatagat tgaccaaata tacgcccatc tagtatacca actcctgcta taatagctaa
     9901 catagtagct tgtactaaca tattgaacct ccattttaac ttagtttaat ttacattaaa
     9961 ttacattaca tttttgattt tgttttgatt ttctaataac tcatttacat aaacaattcc
    10021 attttttgct tcctctaatc ctgatttaac tattagtttt gtatcctcct caactaataa
    10081 aagtatagat aaaagcattg gtaaatttac tcctgtcaat aattcaaatt tgaacccttg
    10141 taaaagtaag tttgtacata tgtttgccac acttccacca aaaacatctg ttaagacaac
    10201 aaattcttca ctatctttat tatttgataa tatacttcta atttctttct cagcatcatc
    10261 tgctgattta tccgttgtca tacaaaaata ctcaatatta gttaatgaac caattattaa
    10321 tttacttgtg tcaacaagct ctctggacaa ttctccatgt gttgcaatta gaaatttttt
    10381 cattctcttt ctcctaaatt attttattaa atctgatagt tgtttctttt tgtctctagg
    10441 taacattcta aattctatat caatccctaa atcacctatt tgtttaaagt tatttatatc
    10501 atcatcatca acagcaacta aatctgtaag tttcttcttc ccttcctcat atcttaatcc
    10561 tcctacattt atttctttta atactcctcc tgaattttta gctacaacta aagcatcttt
    10621 ggtatttttt actaacacta atacattgct tttctttgaa gaagcaaatt tttctactat
    10681 ttctccagat tcctctaccc cccttatata taaagttaca ttgctaggtt tcgctaagtt
    10741 cagtgacata gctttcattt ggtcattttt tgcttcatca tttgcaacta gtattacatt
    10801 tatacctagt gatgttgccc atccatatgc aacctgacca tgtatcaatc tgtcatcaat
    10861 tctcatcaaa gataccattt tccccaaatc ctccatcata cattaaaatt tttattgttt
    10921 atactctcat ttatctataa aagcaaaaag tatgccaaat actggcatac ttttttaaat
    10981 ttcattcact tattttgtaa tcttgtattt tactgtggta gaccatagat aatattataa
    11041 atatatccta tctctgaaat tggtatttgc acactataac tcttttctag cacactaaat
    11101 gcatttttta ttagttttac ttcactatga tggtttttga ttaacaaatc catatcagta
    11161 tactcttcaa tttcagtttg tctaactaat ctttcaatca tacaacttaa gtgaacatat
    11221 aaagaaatct ttttatcatt tgaaagtttt ttcttttgaa tattttctat agcattaatt
    11281 ccttcttcta ttctctctat tatctttttt gaatctaaaa tagttagact atctattact
    11341 ctaattaatg aaaaattctt tacaatagaa tcatttatgt tctttatttt ttcattttct
    11401 actactctgc taaatattct aaaaacatca tcttctcctt ttcctgatat tatatcctct
    11461 aataatataa aatctacccc attcacattt ggattggcag ttcctactat agccatcaca
    11521 tcatacattt caaaaactgg ttctttatct cccatagaaa caagactatc ataatcataa
    11581 ggtattattt tgacatcaac tattccaatt aaactttcgg aaagtagatg ttggattttt
    11641 atagcagtac ctatccctgt aaaacaagat gatattatag catattcttt atttttttga
    11701 ggataataca attgtatatt aggtttagtt tcttcatcca taatttctgc aatctcttca
    11761 atgtttttac cttgcattaa taaatttcct acttctagtg cagaaatagt ggatatttgg
    11821 tctataaata acattgggct atttatctta ttctttaaat cttcatatat aagattaaga
    11881 gagcccatat caaataacac aattaaacca ttctttatcc tatctccctc taggtatcta
    11941 gacatttgtt ttgatacatc cgcaatagta gcatctatag gcatatcaat agctgtaaat
    12001 atatttttac ccaacatccg attacataca ttcgccatac tactggcagt agcatatcca
    12061 tgtgctataa tagtcgcatt aacttgatta aatttcattc ttataattgt tgatttaata
    12121 aatataatca ttatgattat atctacatta ttaagataca tatccaatct attcgttatt
    12181 aatgttgata ttttacttat tatagagtat tctttgtaac tctctttttt taaatatatt
    12241 agtaatttat tttctaaagc tttatactca tcagacaatt gataagattc gtccttcaaa
    12301 taaagataag acgaaaatgc caatacatta ttcccatcat attttatatt gttattaact
    12361 tctaaatttc taaatatatc ctgcattatc gatattataa gctccataag tacgttatta
    12421 ttttcatcat tatttgaaaa gactaaattg tccattagtc taatcattag attagaactc
    12481 tttttactaa atttttcctt tgttatttca tttttttcta gtctatcaaa gtaatctaaa
    12541 cattttatga aactttgata gattatattt cttttatttc ttccatttga catttcaata
    12601 ctaaattgtt taggagaaaa gataatgctt ttgcttttac cactttggaa ttgaaatata
    12661 tctacatttt ctatataaag atttctagga aggtcttgaa gagtaacaaa aatatttcca
    12721 tttcttcttt gattttttgc ataagctcgt ccacatgcat attttattac atttttacat
    12781 tcacctatat tccccttgaa ttttatcttt aaaatcgcat ttaatgtaat ttgagttatc
    12841 tctataggca aaccaagtac cttactttct tcataaataa aatgttctac aatctttctt
    12901 ttttcaatag tccctctttc ttctatattg ggaacataaa tatttatggg tattcttctt
    12961 aaaaaggttt gtaaaaattc agatagactt tctgttgtag caaatattaa tcttacccta
    13021 gcttttctaa ttactccatt ctctccaatc ctagaaaacg tacctgtatc cataaatgta
    13081 aataactttt cctgaccttc actatttaat ctatgtactt catctaaaaa taaaacacca
    13141 ccatctgatt gttctattag acctgctcta gattcatttg ctccagtata tgctcctttt
    13201 acatgcccaa ataatagact agacaataac tccaaattat tataatactg cgcacagttt
    13261 aacacattgt atggagaatt tttttctaat acattactgc ttacactata tttgtatatt
    13321 atcttggcta aaaaagtttt tcctactcca ctttcacctg tcagcattat tgtaagtccg
    13381 ccatttggat aaagtacagc ggtttttatt tgttcgatta cttcttttaa gctattatca
    13441 tatcctatga tactattaaa cacagtctct tgctttaata atttacactc atttttaagt
    13501 tcatctaaat tttcataaat actttttttt gtaggtccta ctacatcatt tattttattt
    13561 ttaggtaaaa aaataacagg tctactgttt atctttataa gattatcaga ttttactaaa
    13621 tcatttaata atctacttga ttgagttcta cttaaattaa acttttttac tatatcttct
    13681 gttattatgc cactttcttt tttaagttca tcaaagttgt taaataatac acattcattt
    13741 acaaaactta aaatttcatc cctcatgttc aacctccaat acaaatatca ataatactat
    13801 aatattagta tatcatttat atatttatga aaaagataat tatattccta tcttgattct
    13861 cttttgtaag tttgtaaaat caaacttttt ataagtataa aatctagatt ttttaacata
    13921 atctcaaggt tcttatcttt c
//
LOCUS       DAEHWM010000102        13832 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.105, whole genome shotgun sequence.
ACCESSION   DAEHWM010000102 DAEHWM010000000
VERSION     DAEHWM010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 13832)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13832)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13832
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.105"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            428..1078
                     /locus_tag="KNP36_003128"
     CDS             428..1078
                     /locus_tag="KNP36_003128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HBF0874978.1"
                     /translation="MDFISSILQGLLSILFNFTGDFGISIVLITLIVKLVLMPLSLKQ
                     RFSVKKQQELAEKMEHIKEKYKNDTKELEKQIQVSSVESMKSMLGCLIVLVQMPVVYA
                     LYHVCLDMTKEFTTIIIPWIANLGTFDNLFILPCIYTLIMLASNLVNYIPYLKINSQV
                     KFNKQMAVVTTITSLILTVRTPVAIGLYFITSAIYSLIEDICFRIYFNRKNRIVTK"
     gene            1292..1963
                     /locus_tag="KNP36_003129"
     CDS             1292..1963
                     /locus_tag="KNP36_003129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0874979.1"
                     /translation="MAKILIVEDEKRMQSIIVEYMQKGGYTCITADDGVEALTILKSN
                     NIDLMILDIMMPYLDGFSVCRVSREMTNIPIIILTAKGEEEDKLKGYEYGADDYITKP
                     FSPKVLLAKVNALLRRYTTDIPKNSLSLGKIFIMVASRQVYVEDKLIDLTYKEFELLR
                     LFMENPNQVFSREKLLNCIWGYDFEGNTRTVDTHIKTLRKKLGSEGHHIVTLIRSGYK
                     FEVKE"
     gene            1960..3090
                     /locus_tag="KNP36_003130"
     CDS             1960..3090
                     /locus_tag="KNP36_003130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0874980.1"
                     /translation="MNSLRKIIEKLKNVDISNWIKQNFGLYSVRKKVFLLSKLSGALI
                     ILFYLVVEEFSINSKLEFWIWFIILVIFIMSIDFLLGKFISEPITSINKSAKSMSQLD
                     FSNPCTVNTNDEFGELSRSLNTMSTNLQQALSDLESANIQLEKDVNKERMLLEQRKEL
                     VDTISHEMKTPLGIIRAYTEGLMDEVDEEKKKNYMNVIIEETDRMNNMIVSLLDLSAL
                     EAGVSKLNPERFDFIEFVETVAGRLLIDIPDANFYFTYDLPEYEVFVVADKMRMEQVV
                     ENLVINAKKHVVYNGNLDLSITCENGLLLFEIYNDGRFIEQDEISKIWSKFYRSVQSQ
                     RTGGSGLGLAIVSQILTMQGLEYGVNNRDRGVEFYFMIPIDE"
     gene            3510..4355
                     /locus_tag="KNP36_003131"
     CDS             3510..4355
                     /locus_tag="KNP36_003131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0874981.1"
                     /translation="MIKVGELKFSYGKDKQILHGLNFEVKEGEIFGFLGPNGSGKSTT
                     QKILNGVLKGYNGHVSLFGKEVKAYTESLYQKIGVLFEFPYLYTNLSAIDNLEYFSSF
                     YPKNQRRDIYELLDLLEFKKEFINKPVSSYSKGMKQRISMARALVSNPKLLFLDEPTS
                     GLDPSGAVLFRKIIEEERKKGTTIFLTTHNMLDADLMCNNVAFIADGKIMVIDKPKNL
                     KMKNSNNKVEVEFVYNGNRDIEIVDIQELESGITFKYDEILSVHSKEPTLEEVFIKYT
                     GRMLV"
     gene            4355..5383
                     /locus_tag="KNP36_003132"
     CDS             4355..5383
                     /locus_tag="KNP36_003132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874982.1"
                     /translation="MYSKFFTLVKKDFWMMIYGKFFVLTLGSLILYSCYINFGYVKFM
                     DEDSYHNNVYLYNPENISMSASPLINQVSSIGELKAKLDEDTSAVCIDMSSSKPKVIL
                     HESIKGVDDYRADYALSLLSSEKDHNSKISDNNAIIQINDKDTSEIKQRKDMTCEILF
                     FEIVAIGFLGIASLLFKEKQMGVMRITGILPVKRSLFILSKIFAFLICDLCFTVLLVV
                     FNIGFFEGIKILPQVLVQASILSIIMSLIGIGCSMLLRDFKQFSLIYLVVAVFITTPI
                     FLSANTSFEIDWIKYHPFYHVYSQLKNAFFMNFSKELVYFVVCSLTIIVLFLLVKYIF
                     NKELVREG"
     gene            5386..6399
                     /locus_tag="KNP36_003133"
     CDS             5386..6399
                     /locus_tag="KNP36_003133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0874983.1"
                     /translation="MIGLRYQLKSIKKDKMCIISFFLPVVMAILINFMGTIDISSLGE
                     IRFGIVKDTLPVQTEQWLKKYGMVSVYDTKMHLIREIKDIKTDTIGVVRDGKGIKTVL
                     YGNEINAIKNVGKTLPEMFRLKGDLKDVEVTILPKDSILKEFQNVFIAMILITAMFMG
                     CTFNAMNIISEKEDGISFINEVLPQSRSQYIIQKVFLGLLCGCLSSMITVFICLDISI
                     LDMIMMLLLVVFSAFISSLIGLFIGKLSEGLMVGIVYIKIVMILFIGTPLLIYLLGVN
                     TSGIGNLYYIMPSVATFNGIMEIINGNVIIIKDIVILAVHCVVWFMIYIILDKKRKLF
                     FSR"
     gene            complement(6916..8166)
                     /gene="cme"
                     /locus_tag="KNP36_003134"
     CDS             complement(6916..8166)
                     /gene="cme"
                     /locus_tag="KNP36_003134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter Cme"
                     /protein_id="HBF0874984.1"
                     /translation="MENKNTNSTWKKKVILFLASQYISLFGSSLVQMAMIWYVTLQTS
                     SGVWVTVLTVCSFIPQMIISFFAGVWADYYNRKVLIIVSDSTIAISTLVLILFMMSSN
                     GTTSELIAISVISVIRSLGSGVQTPAVNAMIPQLVPEEHLMRFNGINSSLQSIVQFIV
                     PIVAAAILGFGNKINQVLLIDVFTAIIAIVLLIFIKIPKHDIPKQTEKVSFFADMVSG
                     IKYCFSDKFIRKVLFTYGAFMLLCVPSGFLIGLLIERTFGKGYIYLSIIEMIGFLGMV
                     LGGLIIGVFGGFKNRNKTFFLAILSYAIFSIILGLVTQAWQFFIFMFFTNFSIPIIQA
                     SAMTMLQEHVAPQMLGRVLSLPIIIYTGFIPLGMMIFGPMADVISINNLIIIAGIILL
                     FFALAIPYSKQFYKQGISKSNESE"
     gene            complement(8252..8998)
                     /locus_tag="KNP36_003135"
     CDS             complement(8252..8998)
                     /locus_tag="KNP36_003135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0874985.1"
                     /translation="MDTYTTSEVADLIGVHPNTVRLYEELNLIPKPKRNTNGYRIFND
                     FHIEQFRFARTALKIEVVQRGLRKDALEIVRTSANRDFDKAISLVNQYLQQLEIEKSN
                     AEEALTIVAQILNGNTPETNKLFLTRKETAEHLNVTIDTLRNWEMNGLLKVKRKQNGY
                     RVYTDEDIKRLKIISALRCANYSLSAILRMLNALSSNPNTNIKTVLDTPKDDDEIISV
                     CDKLITSLKEAEHNAKTMKSHLQIMKKQFS"
     gene            complement(9113..10135)
                     /locus_tag="KNP36_003136"
     CDS             complement(9113..10135)
                     /locus_tag="KNP36_003136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /protein_id="HBF0874986.1"
                     /translation="MNKNNCLDLIFEKVNPSSVGMSSEKLSQLEPLIISQYSNINGII
                     IARKGKVVFEKYYNGYNADDTFHVASVTKSIISALIGIAIDKGYIKDVDQKVVDFFPE
                     YTYSPSEICKKAVTIRHLLTMTAPYPFKNMTESLERLCKQKDWIKYTLNQLGQKGEIG
                     TFKYSSAGTHLLSAIITKTTGKSAREFANEYLFKPIGMKVIPDYDMKDFGFEDFFGKN
                     LKGWAKDRQGYSIGGWGLTLSARDMLRFGFLYLNDGIWNNKRIISKSWIEESVKMNSN
                     EYGYLWWLCKKDGVLWYSAMGAGGNAICCIPQYDLVIAIPSKIVFKPRDRWEFIEKYI
                     LTSIID"
     gene            complement(10135..12555)
                     /locus_tag="KNP36_003137"
     CDS             complement(10135..12555)
                     /locus_tag="KNP36_003137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HBF0874987.1"
                     /translation="MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDI
                     VFEEGRKQYLQSLGILAGIDSEDKFDNIQGLAPTIAVQQNIIRQSNPRSTVGTRTNIL
                     NMLTLLYSVEGQIMCTMCDTPVSYNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGH
                     GAYFEINIEKLVLDKHDTLKQVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEVRNE
                     VLYGHYENGKKSSSLSKVFHNRYKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGK
                     HIGELGKMTILEIDDFLKLLINQGNLNTFGTNLVNDILSKTQHLIESRLGHLSLYREM
                     STLSGGEMQRLFLNSHLDSEMDSLIYVLDEPTAGLHESEKIDILKSIKKLKDLGNTVI
                     VVEHDKNTIKMAEHIIDIGPKAGVEGGQLVYQGDLEGLLQSDKSLTGQYLSGKYPMPN
                     RTSNKNITHTDKIPCITIQNANTNNLKNVTVSLPLGAMVGISGKSGSGKSSLISDTLL
                     PLLRSQFNNHTINNQINSSESEIGEEDDYAVVETIADRLIGTKHISGYSEISQSPIGK
                     NMNSTPASYIGIWDKIRTLFAGQPESLERGFTAGHFSFNSKGACPKCSGSGYEKVWLG
                     NNLSIDHICSECQGKRFNDESLSIKYKNKNIHDILNMSVSESVHFFKDIPNIVSHLNV
                     LEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNGNILYVLDEPTTGLSLYDTSK
                     LIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGDKGGYIIAEGSPKTLKENP
                     KSITGRYL"
     gene            complement(12641..13561)
                     /locus_tag="KNP36_003138"
     CDS             complement(12641..13561)
                     /locus_tag="KNP36_003138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0874988.1"
                     /translation="MTNAKSKKEYLNRICKVQDYIEEHLHEPLSLDELSNIAGFSKFH
                     FHRIFKAIEKETLAQYVNRLKLENATAFLIHRTDMTVTDIAHYFGFTDSAVFSRAFKN
                     YYKISPIKYRNNYSKNCKEPYKISQYNRSISKPKCKNTREVKGEIEILELDNMNTIYT
                     RYTGSYGNLTSTFPKLLERLFTYASEQNLLGLENTQILAIYHDNPQFTQEHQLRTSIC
                     MTIPDNIVVKENDNLGNMIIPSGKYLVGHFDISKSEYSDAWDFMYNEWLSNGNYKLRA
                     SFPFEVYLNNPHNHPQNRHLVDIYLPIEPF"
BASE COUNT         4868 a         1801 c         2176 g         4987 t
ORIGIN      
        1 aaaatgataa atataataat atatatattt acattaggag ttttctatac tataattatt
       61 taaaactaaa tataaatgtt ggaattattt aggacttgaa attgtctaaa aataaatata
      121 agtgatgaag aggtgatgtg atgagattag atatggatag tatgttatat gtactaattt
      181 atatgacatt attggtatct atcattggaa gtatatttta tttttgtaaa gacctcttaa
      241 atcataaaat taagtatgtt ttaataagag acatatttgt aaatagaatt acatattctg
      301 aagaacggtt gcctaaacag tatatagttt ttcagaaata tgatatttgg aggtattgta
      361 gtttgtttta atttgaaatg aatctattat aaattctaaa gtttaaaaat aaaaaggaga
      421 gaataaaatg gatttcattt caagtatatt gcaaggatta ttaagtatat tatttaattt
      481 tacaggtgat tttggaattt ctattgtact tataacttta atagttaaat tagtacttat
      541 gccactatca ttaaaacaaa gattttctgt aaaaaaacag caagaattag ctgaaaaaat
      601 ggaacatata aaagaaaagt ataagaatga tactaaagaa ttggaaaagc aaatacaagt
      661 aagttctgta gaaagtatga agagtatgct gggatgtctt atagttttgg ttcaaatgcc
      721 agtagtatat gctttatatc atgtatgttt agatatgaca aaggaattta caacaattat
      781 aattccatgg attgctaatt taggtacatt tgataatttg tttatattac cttgtatata
      841 tacattaatt atgttagctt caaatttagt gaattatata ccatatttaa aaataaattc
      901 tcaagtaaag tttaacaaac aaatggctgt ggtgactacc ataacaagtc ttatactaac
      961 tgttagaact ccagtagcca taggtctgta ctttataaca agtgcaattt attcattaat
     1021 tgaagatatt tgttttagaa tatattttaa tcgaaaaaat agaatagtga caaaataata
     1081 taattattat tagaaatatt ttagcctgct aacatagaaa aagttagtag gctattttta
     1141 tctatgatat caattccatt aagaatagtc taaaaaatac tatcaaaatg ctataaaaaa
     1201 tactatcaaa atactataaa aaaatagttg aaaaataaat aaattaatat aaactaaaat
     1261 aaagcctaca aaaaagaggt gataaataga aatggctaaa atactaattg tagaagatga
     1321 aaaaaggatg caaagtatta ttgtagaata tatgcaaaag ggaggatata cttgtataac
     1381 tgctgatgat ggagtcgagg cacttacaat attaaagagc aacaatatag atttaatgat
     1441 attggatatt atgatgccgt atttagatgg attttcagtg tgtagagttt cacgtgaaat
     1501 gactaatata cctattatta tattgacagc taaaggtgaa gaggaggaca aattaaaggg
     1561 ttatgaatat ggcgcagatg attatataac aaaaccattt agccccaaag tacttttagc
     1621 aaaagttaat gccttgttac gtagatacac tactgatatt cccaaaaatt cattgagttt
     1681 aggaaagatt tttattatgg tagcatcaag gcaagtgtat gtagaagata aattgattga
     1741 tttaacatat aaagaatttg aattattgcg tttatttatg gaaaacccta atcaagtttt
     1801 ttccagagag aaacttttaa attgtatatg gggatatgat tttgaaggaa acacacgaac
     1861 tgtagataca catataaaaa ccttacgcaa aaagcttggt agtgaaggac accatatagt
     1921 tacattaatt cgttcaggat ataagtttga ggttaaggaa tgaatagttt aagaaagatt
     1981 atagaaaaac tgaaaaatgt agatatttca aattggatta aacaaaattt tggactatat
     2041 tcagttagaa aaaaagtgtt tttactttct aaattatcag gagcgttaat tatattattt
     2101 tatctggttg ttgaagaatt ttcgataaac tctaaattag aattttggat ttggtttata
     2161 atactggtta tatttattat gagtattgat ttcttattgg gaaaatttat ttcagaacca
     2221 atcacatcta taaataaatc tgcaaaaagt atgtcccaac ttgatttttc taatccatgt
     2281 actgtaaata ctaatgatga atttggagaa ctttctagga gcctgaatac aatgtctaca
     2341 aatctacaac aggcattatc agacctagaa agtgcaaata ttcaacttga aaaggatgta
     2401 aataaggaaa gaatgctatt ggaacaaaga aaggagttgg tagatacaat ttcacatgaa
     2461 atgaagactc cacttggcat tatacgtgcg tatacagagg ggcttatgga tgaagttgat
     2521 gaagaaaaaa agaaaaatta tatgaatgtt ataatagaag aaactgatag aatgaacaat
     2581 atgattgtat cattattaga cttatctgca ttggaagcag gagtttctaa acttaaccca
     2641 gagcgttttg attttataga gtttgttgaa actgtggcag gtcgtctttt aattgatata
     2701 ccagatgcca atttttattt tacatatgat ttgccagagt atgaagtttt tgtagtggca
     2761 gataaaatga gaatggaaca agtagtagag aatctagtta ttaatgcaaa gaagcatgtt
     2821 gtatataatg gtaatttaga tttatcgatt acatgtgaaa atggcttgct tttatttgaa
     2881 atttataatg atggtaggtt tatagagcaa gatgagattt caaagatttg gtctaagttt
     2941 tatcgtagtg ttcaatctca gcgtacagga ggttcaggtc tagggcttgc aattgtttca
     3001 caaatactta caatgcaagg gttagaatat ggagtgaata atcgtgatag aggagtagag
     3061 ttttatttta tgattccaat tgatgaataa tttagtatta atttataaat tataagtatc
     3121 tgatgtaaaa tatttttctt tgtatatgta agcatttaaa gagaataaaa taaaaaaact
     3181 taatgaaaaa agcttaatga aaaagtctaa taaaaagctt aatgaaaagt cttgtttttc
     3241 tgatgaaaac aagatttttt attaagcttt ttattatttc acttcgattt cacaagagag
     3301 acactctgat ttcaccaaat agaaataaaa taggttaaat aaattaaaaa atagaagcgt
     3361 aattaaataa ggttacaagg gggagtactt atgaaatggt atacatggtt gactattata
     3421 ttgataatat tgctttctat tccgcttaaa attaaattta taaaatggtg ggatagacga
     3481 caaaaaaatg ataaaggagg ttatgataga tgataaaagt aggagagtta aaattttctt
     3541 atggaaaaga taaacagata ttgcatggac ttaattttga agtaaaagaa ggagaaatct
     3601 ttggattcct tggacctaat ggttcaggaa aatccacaac acagaaaatc ttaaatggtg
     3661 ttttaaaagg ttacaatggt cacgtatccc tttttggtaa ggaagttaaa gcatacacag
     3721 aatctttata tcaaaagatt ggtgttttat ttgaatttcc ttatttatat accaatttaa
     3781 gtgcaattga taatttagaa tatttttcgt ctttttatcc taaaaatcaa aggagagata
     3841 tatatgaact cttagatttg ttagagttta agaaagagtt tataaataag cctgtatcat
     3901 cctactcaaa aggtatgaag caacgtatta gtatggcaag agcattggta agtaatccaa
     3961 agttgttatt tttagatgag cctactagtg gacttgaccc atctggagct gtactatttc
     4021 gtaagattat tgaagaagaa cgaaaaaaag gaacaactat ctttttgact actcataata
     4081 tgctagatgc agatttaatg tgtaacaatg tggcttttat tgcagatgga aagattatgg
     4141 taatagataa acccaaaaat ttaaaaatga aaaatagcaa taataaagtt gaagtggaat
     4201 ttgtatataa tggaaatcga gatattgaaa ttgtagatat acaagagtta gaatctggaa
     4261 taacttttaa atatgatgaa atcttaagtg tacattcaaa agaacctaca ctagaagaag
     4321 tttttattaa atacacagga aggatgttag tgtaatgtac tctaaatttt ttaccttagt
     4381 aaaaaaagat ttttggatga tgatttatgg taaatttttt gtgctgacac ttggctctct
     4441 catactttat tcgtgttata ttaattttgg ttatgtaaag tttatggatg aagatagtta
     4501 tcacaataat gtatatctat ataatccaga gaatataagc atgagtgcat ctccattaat
     4561 taatcaagtt tcttctatag gtgaattaaa agcaaaactt gatgaagata caagtgcagt
     4621 ttgtattgat atgagttcca gtaagccgaa agtaatttta catgaaagta ttaaaggagt
     4681 tgacgattat agagctgact atgcattgtc attattatca tcagaaaaag accacaatag
     4741 caaaatatca gacaacaatg caataattca aattaatgat aaggatacat ctgagataaa
     4801 acaaagaaaa gacatgactt gtgagatttt attctttgaa attgtagcta ttggattttt
     4861 agggattgcc tctttattat ttaaagaaaa gcagatggga gtaatgcgta ttactggtat
     4921 tttacctgta aaaagaagtc tttttatatt atcaaagata tttgcttttt tgatatgtga
     4981 cctatgtttt acagttcttt tagtagtatt taatattgga ttttttgaag gaataaaaat
     5041 acttccacaa gtattagttc aagctagtat tttatcaatt attatgtctt tgattggaat
     5101 aggatgctca atgttattga gagattttaa gcaattttct cttatatatc ttgtggttgc
     5161 tgtattcata actacaccta tatttctatc tgcaaataca tcttttgaaa tagattggat
     5221 taaatatcat cccttctatc atgtttatag tcagcttaaa aatgcgtttt tcatgaattt
     5281 ttcaaaagaa ttagtttatt ttgtagtgtg ttctttgaca ataatagttc tatttttact
     5341 tgtaaaatat atttttaata aagagttggt tagggaggga taatcttgat aggattacgt
     5401 taccagttaa agagtataaa aaaagataaa atgtgtataa tttccttctt tttaccagtt
     5461 gttatggcga ttttaataaa ttttatggga acaattgata tatcttcatt aggagagata
     5521 cgttttggta tagtgaagga tacacttcct gtacaaacag agcagtggtt gaagaagtat
     5581 ggtatggtaa gtgtatatga cacaaaaatg catttaatac gtgaaattaa ggatattaaa
     5641 acagacacaa ttggagttgt tagagatggt aaagggataa aaactgtgct ttatggaaat
     5701 gagattaatg ctataaaaaa tgttggaaag acattgccag agatgtttag actaaagggt
     5761 gatttaaaag atgttgaggt tacaatattg cctaaagata gtattttaaa agagtttcaa
     5821 aatgttttta ttgccatgat tttaattact gctatgttta tgggatgcac ctttaatgca
     5881 atgaatatta tatctgaaaa agaagatgga atatcattta taaatgaagt tttgccacag
     5941 agtagaagtc agtatattat acaaaaagta tttttgggtc ttttatgtgg gtgtttatct
     6001 tcaatgataa ctgtatttat atgtttggat atttcaatat tagatatgat aatgatgttg
     6061 ttactcgttg tattttcagc atttatttca tcacttatag gtttatttat tggaaagttg
     6121 tcagaaggtc ttatggtagg aattgtttat attaaaatag taatgatttt atttataggt
     6181 actcctttgt taatatatct tctaggggtt aataccagtg gtatagggaa tttatactat
     6241 ataatgcctt cagttgctac atttaatggt attatggaga ttattaatgg taatgtcatt
     6301 attatcaaag atattgtaat tttggctgta cattgtgtag tatggtttat gatatatatt
     6361 attttagata aaaaaagaaa gttatttttt agtagataac tcagtataat tataattggg
     6421 acaatttaat aggtgattta atatactttg tatagtgtaa tttatgtagt gcaatttgta
     6481 tactttaatt tatgtagtgt aatagttagt tttattttat aattattcaa tataatttag
     6541 taagaagttc agtacaatta gagctactta gtggaaaact taataggtac ttaaactata
     6601 taaatacttt attttcctcc atttgtacta taaatttaat ttatgatata aatggaggta
     6661 ttattatatg atttgataaa tttcatcatt ataacctaca agtaaaggta ttattatata
     6721 aagttaataa agatagtatc aaaatattat ttgctataaa gagaggggct caaaataaag
     6781 ataaacctat ttttcaatgt tgaaatgata aaatatattt gatttcatat aaaaaatttt
     6841 cttcataaat taaaaagtcc attttaagcc ccctcatttt taaccagata aatcgagtta
     6901 aactatttaa atatattact cggattcatt tgacttagat attccttgct tgtaaaattg
     6961 ttttgaatag gggatagcca aagcaaaaaa taaaagtata atccctgcta tgattattaa
     7021 attattaata gaaattacat ctgccattgg tccgaaaatc atcataccaa gaggaataaa
     7081 accagtatat ataataatag gtaagctaag aactcgacct agcatttgtg gtgctacatg
     7141 ctcttgcaac atagtcatag ctgatgcttg aatgattgga attgaaaaat tcgtaaaaaa
     7201 cataaatata aaaaattgcc aagcttgtgt tacaagacct agaataattg aaaaaatagc
     7261 ataggataat attgctagaa aaaaggtctt atttctattt ttaaaaccac caaaaactcc
     7321 tataatcaat ccacctaaaa ccatacctaa aaatccaatc atttcaataa tagacaggta
     7381 tatataaccc ttgccaaatg ttcgttcaat aagaagtcct ataagaaatc ctgatggaac
     7441 acaaagaagc atgaatgctc cataagtaaa aagcactttt ctaatgaact tatctgaaaa
     7501 acagtacttt atccctgata ccatatctgc aaaaaatgag actttttcag tttgttttgg
     7561 tatatcatgt ttaggaattt tgatgaatat caataataca atagcaataa ttgcagtaaa
     7621 tacatcaatt aaaagaactt gatttatttt attaccaaat ccaagtattg cagcagctac
     7681 aataggaact ataaattgta ctatagattg taggctacta tttataccat taaaacgcat
     7741 taaatgttct tctggtacaa gttgaggaat cattgcgttt acagcaggtg tttgtacacc
     7801 acttcctagt gaacgtataa cagatattac tgatatggct attaattcac ttgttgtgcc
     7861 atttgatgac atcataaata gaattagaac taatgtagat atagcaattg ttgaatctga
     7921 tacaattatg agtacctttc gattgtagta gtctgcccat acaccagcaa aaaaagaaat
     7981 tatcatttga ggtataaagg agcatacagt taaaactgtt acccatacac ctgatgatgt
     8041 ctgaagtgtg acataccata tcattgccat ttgtacaagt gatgagccaa ataaggaaat
     8101 atattgactt gctaaaaaaa gaatgacttt tttcttccat gtagaattag tatttttgtt
     8161 ttccatccta ttcctccttt gatttgtgtg ttgaattttt cttgctctta aggataacac
     8221 acaaatcaaa gtctggagtt agagtggagg gctaggaaaa ttgttttttc ataatttgaa
     8281 gatgagattt catggttttt gcattatgtt cagcttcttt caatgaagtt atcagtttgt
     8341 cacacactga gataatttcg tcatcatctt ttggagtgtc aaggacagtt ttaatattag
     8401 tattaggatt agaagataaa gcatttaaca ttcgtaaaat agctgaaaga gaatagtttg
     8461 cacaacgaag tgcgcttata attttaagtc gttttatatc ttcatcagta tatacacgat
     8521 aaccattttg ttttcttttt acttttaaca aaccattcat ttcccaattt cttaaagtat
     8581 ctattgtaac gtttaagtgt tctgcagttt cttttctagt taaaaagagt ttatttgttt
     8641 ctggagtatt tccatttaaa atctgtgcaa caatagtaag tgcttcctcg gcattagatt
     8701 tttctatttc taattgttgc aagtattgat ttacaagact aatagcctta tcaaagtccc
     8761 tattcgctga tgttcttaca atctcaaggg catcttttct taatcccctt tgtaccactt
     8821 caattttcaa ggctgtacga gcaaatctaa attgttctat atgaaaatca ttaaagatac
     8881 gataaccatt ggtattacgc ttaggtttag gtattaagtt tagttcttca tataaacgta
     8941 ctgtattagg atgtacacca attaaatctg ctacctctga tgtcgtgtaa gtgtccatta
     9001 gtattcaact ccttttagat atatagtatt agtcataata acaccaaaca aaagtctggt
     9061 gttataatgg agggtttggt tatctaagag taattaattt atgaaagagt aattaatcta
     9121 ttatagaagt aagtatatat ttttcaataa actcccatct atcacgaggt ttaaacacta
     9181 ttttagatgg tatggctatt actaagtcat attgtggaat acaacaaata gcatttcctc
     9241 cagctcccat tgctgaatac cacaaaacac catctttttt acatagccac cacagataac
     9301 cgtattcatt actattcatt ttaactgatt cttcaatcca cgatttagat ataatacgtt
     9361 tattattcca aataccatca tttaaataca gaaaaccaaa tcgcaacata tctctagcac
     9421 tcaatgtaag tccccagcca cctatagaat aaccctgtct atcttttgcc caacccttaa
     9481 gattttttcc aaagaaatct tcaaaaccaa aatctttcat atcataatct ggtataactt
     9541 tcataccaat aggtttaaat aagtattcat tagcaaattc acgagcagat tttccagtag
     9601 tttttgttat aatagctgaa agtaggtgcg ttccagctga agaatatttg aaagtaccaa
     9661 tttcgccttt ttgaccaagt tgattcaagg tatattttat ccaatctttt tgtttgcaaa
     9721 gtctttctaa agactcagtc atatttttaa aagggtatgg tgcagtcatt gtaagtaggt
     9781 gacgtatagt tactgctttt ttacatattt cagaaggact ataagtatat tcagggaaaa
     9841 aatcaacaac cttttggtca acatctttta tatatccttt atctattgca atacctatta
     9901 aggctgatat aatacttttt gtaactgatg caacatgaaa agtatcatca gcattatatc
     9961 cattatagta cttttcaaag acaacttttc cttttcttgc aataattatt ccatttatat
    10021 tactatattg tgagattatt aaaggttcaa gttgtgagag tttttctgaa ctcatgccaa
    10081 cacttgaagg atttactttt tcaaatatta aatctaagca attgttttta ttcattaaag
    10141 atacctccct gttatagatt ttggattttc ttttagagtt tttggagaac cttctgcaat
    10201 tatataacct cctttgtcac caccttctgg accaagctca acaatccagt cacaaacatt
    10261 taatacatct atatcatgtt caacaacaat tacagaattt ccattttcaa ccaattcatc
    10321 taataattga atcaacttag aagtatcgta tagacttaga ccagtagttg gctcatccaa
    10381 tacataaagg atattaccat ttcgtttttt accaatttct tttgcaagtt tgattctttg
    10441 ggattcacca ccacttaaag ttggtgtagg ttggcctaat tttatatacc ccatacctat
    10501 ttgttctaat acatttaagt gtgaaacaat atttggaata tccttgaaga aatgtacaga
    10561 ttcagaaaca ctcatattta aaatatcatg tatattttta tttttatatt taatagataa
    10621 agattcatca ttaaatcttt ttccctgaca ttcactgcat atatggtcta tacttagatt
    10681 atttcccaac cagacctttt catatccact accactacat ttaggacaag cccctttgga
    10741 gttaaatgag aaatgaccag ctgtaaatcc tcgttctaac gattctggct gacctgcaaa
    10801 tagtgtacgt atcttatccc atataccaat ataagaagca ggagttgagt tcatattttt
    10861 gccaatagga gattgagata tctctgaata tccagaaata tgtttagtac caatcagtct
    10921 atctgcaata gtttcaacaa ctgcataatc gtcttcctca cctatttcac tctctgaaga
    10981 atttatttga ttattgatag tatggttatt aaattggctt ctaagaagag gaagtagggt
    11041 gtctgatata agtgaactct tgccactacc tgattttcca gatattccaa ccatagcacc
    11101 caaaggtaat gatacagtta catttttaag attatttgta tttgcatttt gaatagttat
    11161 acaaggtatt ttatcagtat gtgtaatgtt tttattgctt gttctattag gcattggata
    11221 ttttccagat agatactgtc cagtgagtga tttgtcggat tgaagtagac cttctaaatc
    11281 tccttgatat actaattgac caccttcaac accagctttt ggaccaatat caataatatg
    11341 ttctgccatt ttaattgtgt ttttatcatg ctcaactact atgaccgtat tgcctaaatc
    11401 tttaagtttc tttattgatt ttaagatgtc tattttttct gattcatgca atccagctgt
    11461 tggttcatca agcacataaa ttaatgagtc catctctgaa tcgagatgtg aatttaaaaa
    11521 tagtctttgc atttccccac cactcaaagt tgacatttct cggtataagg atagatgacc
    11581 taatcgtgat tctattaaat gttgagtttt ggataaaata tcatttacaa gatttgtacc
    11641 aaatgtgttt aaattacctt gatttattaa gagtttaagg aaatcatcaa tttctaaaat
    11701 cgtcattttt ccaagttctc caatatgttt tccgtttaaa agtactctac gtgcttcttc
    11761 accaatttta aaaccattgc aatctgaaca ggcagtcata gtataaactc catttaaatc
    11821 ttcgcccctt ttgtaacgat tgtgaaatac ctttgataaa gaggaacttt ttttaccatt
    11881 ttcataatga ccatagagta cttcatttct tacttcttca ggtagttgta agaattgtat
    11941 gtctaaataa tcattgaatt ttttagaaaa tactctcaaa tatccaggtg taatctttgc
    12001 tctatctaag acttgtttta gggtatcatg cttatcaagg actaattttt caatattaat
    12061 ctcaaaatat gcaccatgtc cagagcactt catacacatt ccatctgaag agttgtatga
    12121 gaaataactt ggtcttaatc gttcttcctc atatccacaa ttattgcaaa ttagattata
    12181 gcttacagga gtatcacaca tagtacacat tatttgacct tccactgaat acaatagtgt
    12241 aagcatgttg agaatattgg ttcttgtgcc tactgttgaa cgaggattgc tctggcgaat
    12301 aatattttgt tgaacagcta tagtgggagc taaaccttga atattatcaa acttatcttc
    12361 actatcaata cctgcaagta tacctaaaga ttgcagatat tgtttacgcc cttcctcaaa
    12421 tacaatgtca aacataaggc tagacttacc tgagccactg acacctgttg caacaacaag
    12481 cttatctttg gggatagaaa catctatatt tttaagattg tgtatctttg ctccattaat
    12541 ttttatttct ttcattggtt cacctcattt tatcaatttt atcaaaccgt aaaataggga
    12601 tatattaatc cttaatacaa gaatagatta ggtgaggtta ttaaaaaggt tctataggta
    12661 aatatatatc gaccaagtgt ctattttgag ggtgattgtg tgggttgtta agatatactt
    12721 caaaagggaa ggaggcacgt agcttataat taccatttga tagccattca ttatacataa
    12781 aatcccacgc atcactatat tcagattttg aaatatcaaa atgtcccaca agatattttc
    12841 cagaaggtat tatcatattg ccaagattgt cattctcttt gacaacaatg ttatctggaa
    12901 tggtcatgca aatactagtc cttaattgat gctcctgtgt aaattgtgga ttatcatgat
    12961 aaatggctaa tatttgtgtg ttttcaagtc caagtagatt ctgctcactt gcatatgtga
    13021 ataaccgttc taaaagtttt gggaaagtac tggttagatt accatatgaa ccagtatacc
    13081 tagtgtaaat agtattcata ttatcaagtt ctagaatttc aatttcacct ttaacctctc
    13141 tagtattctt acatttaggt tttgatatgc ttctattgta ctgagaaatt ttatatggtt
    13201 ctttgcaatt cttgctataa ttgtttctat attttatagg gcttatttta tagtaatttt
    13261 taaatgctct tgagaaaact gctgaatcag taaagccaaa gtagtgtgca atatcagtaa
    13321 cagtcatgtc agttctatga ataagaaaag cagttgcatt ttctagtttt agcctattta
    13381 catattgtgc caaagtttct ttttctattg ctttgaagat tctatgaaaa tgaaattttg
    13441 aaaaacctgc tatattagaa agttcatcaa gagaaagagg ttcatgtaaa tgttcttcta
    13501 tatagtcttg cactttgcaa atacgattta gatattcttt tttactttta gcatttgtca
    13561 tatatagccc tccttattgt gtaaaatgtg tatcaattaa tttatagcaa tatagtaata
    13621 aaattttatg tttttgtaat ttatgataaa taagatagcg tttaattttt tataattgat
    13681 aaaagatatt tataattaat aaaagatatt tataattaat aaaagatata agatgcctta
    13741 tatttgtctt tgcatataag tatagtcttc gtaataatta gtataccata gtgatttatt
    13801 tttaattgtg tatttatata aatacacaac tt
//
LOCUS       DAEHWM010000103        12616 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.106, whole genome shotgun sequence.
ACCESSION   DAEHWM010000103 DAEHWM010000000
VERSION     DAEHWM010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12616)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12616)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12616
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.106"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(85..1965)
                     /locus_tag="KNP36_003139"
     CDS             complement(85..1965)
                     /locus_tag="KNP36_003139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp10"
                     /protein_id="HBF0874989.1"
                     /translation="MSKRKSFIRTIAVSTMAVAVTGSATCAYAAPVLQGTKTYEKVNT
                     IDISVDSVENIVYSFQASIKVQGEVEVVDNEQKEKITWSDNIKSQIKSGNANATCRAE
                     YNKSSNTTTLDIYVTSNEDLLDGNRLNIGRISVKKSGSNSNADYKVLGKGTNDKPALK
                     IVTYNNKTVDYENISSDEGLIFTLINESEVKPIGGTGSSKNDPEKYKVEKSEALEYLL
                     NNIRINYSIVSKETQESGSNVILKLGLAQKTTKGRKVTINKYVEVTLPKSLEYIVENE
                     LSKPDELPPDNGSGGNNGGGSNSGGSSSGGSSGGGNSSDSTSNVTVKKLKGDDRFETA
                     IKISQSGWTKSDTVVIVNGEDKSMVDGLTATPLASVKNSPILLSSNDKLPQKTVEELK
                     RLNPSKVVVIGGNNSMPNSVVEAIKAVNSKISVQRIGGDTRYQTSINIAKEIDKTNNV
                     SKLYIGAGNGEADSLSIASLAGKEKTPIVLTQKDGVDNEAEQFIKSNKVSNIYFIGGV
                     EKISNKAIEQVGKIANKDISNNRVAGQTRQETNAKVIDKFYSQSKLDGVVVANQDKLI
                     DALAVGPLAAKNNSPVILATNTLDKSQESSLKGKNSSKLFEVGGGIASSVIDKIKSLI
                     EK"
     gene            complement(2175..8138)
                     /locus_tag="KNP36_003140"
     CDS             complement(2175..8138)
                     /locus_tag="KNP36_003140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="calcium-binding adhesion protein"
                     /protein_id="HBF0874990.1"
                     /translation="MKKAISCVLAVSMCSAPLNVFAEPILEGKLRAVEKSVTEKLRGS
                     LEVDLNFSLPIKNSDSESMTNMQLRLKDDSNNSGIIKLGEKDSGTVNVGTDNIEYTIK
                     KLSASRSEIKNKDENISYYNIVFNNLPVGKYNVEVSGDGFKNKEIKDIDISSYSQRVL
                     LSNRASVDNKNKPLNYELFLMGDVNGDGKVDKSDYNKVLENIDSNKREFDLNRDGKVD
                     IVDLDYVQKNLGQSEDAKSLESIVSTNPIVDTSKVELKGNSDVDINGNVENLFSGENN
                     GVTISSKNDEISEEKPAVMDIALSEALNMEVINIKAPEGTAPAKGIVEVTDKDGNVQQ
                     IPYENKEYMKNLKDEEQQEEVNNEQEEVNQEEVNNKDENINQTDNNSNNKDENNDEQQ
                     ENSDKQEVNSNTNQDKNNDKENSSMDKPNSDEDTPKEEGNISKDDNSTTSTYSKSTLE
                     TYADVQNSDIVINLGKQVAVKKITIKITATTANDRNLAEISKVEFLNNVYKEIPKPEM
                     NIPKINKISTSTAVGNEKVSFYWNNEVNVSAYELILDKIDSKGKVLSTKKLQTSKNTI
                     EVRDIEAYGLYRVSIQSLNGDWSSGYKDATPENLDGVPENVDSNYKPIQFSPDSILEF
                     QVVPDTKPEPPEGINVKGKFKSLDVSWKNHKQAKDFDLYYKEKGSNGSWIKYNDKLIR
                     GTSSKIEGLKDNTTYEVRMTATNHLGTSGMSKTYIGTTESMDAPTTPNYRLINTPKEN
                     GGFGIPTNHIVDVTYPAGYDKSEYSDKNPFDKFNVVDGDFTTHWTFPTYNAAEGTNRG
                     PIITFDKSYTMDTFMATPRFDVSDKTINDFEVRYWDENGQLHNLGDVPFETKTDPVNN
                     NKYVMVRLKEPITATKIQVSVCSSYSYKSNISELKFYEYDSIEDDVRNLFMDDLQVEL
                     KEDVTQEKITELKDRLNTPDKASGEYHPYKTVIERELKLAQDLYNDRATLTDVTTVNQ
                     EINKLGKYKDKNGQYTVNSNNLGMQNDWQALGVAARAGDEITVYVGSKSGKTPKLIYT
                     QYYGESGAYKSGEINLNTGKNVIQLSKLHSLDIECGGSLYIRYAEDTPSGGDIKVRVA
                     GATKIPHLNLNGTINDKSPAGVSESKKKIKAYIEELARYKDAVKGEPYYPGTNVGNSY
                     GYSEKTGVLNTTDIESDKVTLNVPATAVYQGISKGNADLNTQVDRLYNSMLAWEQIMD
                     LVYSERGVFKTQDLDGNGTVDDNEFNLTKNDMAPKSRMNIKYQRMFIGAFMYASGLHV
                     GVEYGSVPGLMNGVPFQIDDSGKATGGNLFGWGIGHEIGHVTDIGKMTYSETSNNVLA
                     LLAQTFDDKTHSRIEGSTMDKIYEHVTSNSLGIPSNVFERLGMLWQLHLAYDDDFTGS
                     MLKNNSDADLSNDTFYAKISRKYRALSSSDPINSLPKDQMLVAMASSVVEKDLRDYFK
                     AWGVEITPELNSIMDSKNYEKESRKIQYVNDEARRKILNENIASMAKDTKVSASFSDG
                     IQSGSLVKSNKISIDLDVDKDKDKILGYEIIRSDGNYLDGENGTQVKYRTVGFVDAKG
                     NSKTKFTDNISPLNNRAFTYKVVAYDYHLNPTEEFEVGTVKLSDEGKINKSAWSFITN
                     TVSDGDVRTENDSHGPLQNPEIDNIKDNDANTTYKGKIISKAEWNKDPQKDPDINVEE
                     NPYIIVDMKETLPIVGLKYTKPETEARKFSLKGLFNFRKNTSTTYNPLTNYKIQVSND
                     KKNWEDVSQGTFEYGQDLVGGGKDQDNEARVTFNKDGKLWTYQARYVKLISNNKSNIE
                     VAELDIIGPPGDNIEIGTMNNADETRTNGIGKLAEDYVYQSDDSSTSEDETGKIPAGS
                     IVITGEYSGNPAFNLPLLIDKNNKTISGEALLFAEVPEKGELGEISKGTWVYYMPKEN
                     FDSLSDKVKAELYRYNDLQGDTPVGQRFVSDTMYVPVGAKNYDELKTISLTDSNSKAR
                     KATRNSIDISNKKVITVSNKVKGNIVRDK"
     regulatory      complement(8262..8347)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            complement(8519..9922)
                     /locus_tag="KNP36_003141"
     CDS             complement(8519..9922)
                     /locus_tag="KNP36_003141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp9"
                     /protein_id="HBF0874991.1"
                     /translation="MKNSKKILAIGLTLFLVMVNTPMVNALTSVEQIKGNDRYETAAK
                     IADKQNYNTAILINSDNSLADGLSASGLAGALNAPILMTKQNQIPNTTMERLNKAKTV
                     YIIGSESTISKNVENQLLSKKKVVQRIFGENRFDTSIKIAEKIKEIKPIDKVIIANGF
                     TGEADAISASPVAARDGVPIILTDGNSVGFDTTGLKSYALGSSEIISDELVKSTNSIR
                     LGGTDRFETNKIVIQEFYKNSKEFYLSKGLQLTDALAASTIAKNAPVVLVENGSNKSI
                     LSGADKLTVLGGINQNVIKQCINQASPNQQGLYYNPNDRAFKERIKGKVYALTKQYRK
                     ENGVRALSVASRLEGLANDWSNLMANKKTLSHTINGKNSYSTFLKYLDWSEIKPGYIA
                     VQGENIIKYKIPDKPVYTNRDADDIGNFIFNEWKTNPEEGTNMLHKGYEIMGFGIAIT
                     GDKNLYATHEFYGRYKE"
     gene            complement(10384..12279)
                     /locus_tag="KNP36_003142"
     CDS             complement(10384..12279)
                     /locus_tag="KNP36_003142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp8"
                     /protein_id="HBF0874992.1"
                     /translation="MLSNKKRSMAIVMAGATVMSAAAPIFADNTVTENVDKNYTVSAK
                     DSAKLIEEVRKALEVKFEDTKAGANVNDRVYDIKVDNVNLTNATQLQNKINSLTEGQS
                     LKVTIQDKGHQVLGGKVVDYKIENYKTAQEIVDAVNAYNATLAEDSDNKLTATIKSTN
                     TVEVKRAKDSANVITLNVGDQHLDFSKVITSEEGTFEGYEKSYSDIDSKELHTITVKN
                     ADLQDISAEELFDGIRLTTLGREIVNKVKNGYALTFENEAILTQEQEDSDDKDKPEKS
                     SFDIVLSKANEKPETISVSSKNHKLVRDLHKVLTDVKGGKELKVEVLSGDSRFTTAVE
                     VSKERFKDGEAEAIILVGEDAIVDGLASAPLASQKNAPILLSKKDSLPSEIEAEILRV
                     LGSNLSSKKIYIVGGESKVSKETEEKLSKLGVSKVERVSGEDRFETSLEIAKQLKDTF
                     KTAFVVGGNGEADAMSISARAAQFGAPIIVTGNELDANAEKLLKGKELEIVGGENSVS
                     KEVEDKLVDIDLNNKVERLAGENRKDTNAKVINKYYAGATKAYVAKDGYVGGNGQLVD
                     ALTAAPLAASSKAPIVLTTEELSKSQEEVVELRLKNATKLVQIGEGIAKNAIEKIAEK
                     INLFTKN"
BASE COUNT         3480 a         2336 c         1401 g         5399 t
ORIGIN      
        1 taagataatg aaaataaaat aagaatgcat ttaaatatat aactttatat ctaaatacat
       61 tcttattttc tatttactta atatttattt ttcaattaaa ctcttaatct tgtctattac
      121 agatgaggct attcctccac ctacttcaaa caactttgat gaatttttac cttttaatga
      181 cgattcttgt gatttatcta acgtatttgt agcaagtata actggtgaat tgtttttagc
      241 tgctaatggt ccaactgcta aagcatctat aagtttatct tgatttgcaa ctacaactcc
      301 atctagctta gattgagagt agaatttatc tattactttg gcattcgtct cttgtctagt
      361 ttgacctgcc accctattgt ttgatatatc tttgtttgct atttttccaa cttgttcaat
      421 agccttgtta gatatttttt ctactccacc aataaaatat atatttgaca ccttatttga
      481 tttaataaat tgttcagctt cattatctac accatctttt tgtgtaagta ctattggagt
      541 tttttcttta ccagccagtg atgctattga taatgaatca gcttctccat ttcctgctcc
      601 tatatacaac ttgcttacat tattcgtctt atctatttct tttgctatat taatagaagt
      661 ttgatatctt gtatctccac ctattctttg tactgatatt tttgaattta cagctttgat
      721 agcttcaaca actgaatttg gcattgagtt gtttccacct atcacaacta cttttgatgg
      781 atttagcctt ttcaattctt ctacagtttt ttgaggaagt ttatcatttg atgataaaag
      841 aatcggtgag ttttttacac tagcaagtgg tgtagctgta agcccatcca ccatactttt
      901 atcttctcca tttactatta caactgtatc tgattttgtc caaccacttt gagatatttt
      961 gatagctgtc tcaaatctat catcaccttt taattttttg actgtgacat tagatgtaga
     1021 atcacttgaa tttcctcctc cagagcttcc accactagat gagccgcctg aattacttcc
     1081 tccaccatta tttccaccac taccattatc tggtggtaat tcatccggtt ttgataattc
     1141 attttcaact atgtattcta aactttttgg aagtgtaact tcaacatatt tgtttattgt
     1201 aacttttctt cccttagttg ttttttgtgc taatccaagt tttaatatta catttgaacc
     1261 actttcttgt gtttctttac taacaataga atagtttatc ctaatattgt ttaataaata
     1321 ttcaagtgct tcacttttct ctaccttata cttttcaggg tcatttttac tagaaccagt
     1381 tcccccaatc ggttttactt cactctcatt aataagggta aatattaatc cttcatcaga
     1441 gcttatattt tcataatcca ctgttttgtt gttatatgtt acaattttta aagctggttt
     1501 atcatttgtt ccttttccta aaactttata gtcagcattt gagttacttc cagatttttt
     1561 tacagatatt cttcctatat tcaatctatt tccgtctagt aagtcttcat ttgatgtaac
     1621 atatatatct aatgtagttg tattacttga tttgttgtat tctgctctac aagtagcatt
     1681 tgcatttcca ctttttatct gagattttat attatcagac caagtaatct tttctttctg
     1741 ctcattatct actacttcaa cctcaccttg tacttttata ctggcttgaa atgaatatac
     1801 tatgttttct actgagtcca cagatatatc tatagtattt actttctcat acgtttttgt
     1861 tccttgtaaa actggagctg catatgcaca tgtagcacta ccagttacag ctactgccat
     1921 agttgatact gctatagttc ttataaaaga ttttctttta ctcattaaca cccgtcctta
     1981 tctatcatta actaagtgga taaatttact tatccaccta gcttttatat ttaatttata
     2041 aattacccta aatttatgat tacatttata tactttactt ttaatatcta ctattttaaa
     2101 actattctag tacctaatct tattagatat acaatgttag tgttagtatt tttacgtttt
     2161 tagagttcca cctactattt atctctaaca atattaccct ttactttatt gcttacagtt
     2221 ataaccttct tattactgat atcaatagaa tttcttgtag cttttctagc tttactatta
     2281 ctatcagtaa gacttattgt ctttaactca tcataattct tagctcctac aggtacatac
     2341 attgtatcac ttacaaatct ttgacctact ggagtatctc cttgaaggtc attgtatcta
     2401 tatagttcag ccttaacctt atcacttaaa gaatcaaagt tttcttttgg catatagtaa
     2461 acccatgtac ctttactgat ttcacctagt tcaccttttt ctggaacttc tgcaaataaa
     2521 agtgcttctc cagatatagt cttattgttt ttatctataa gtagtggtaa attaaatgct
     2581 ggatttccac tgtattcacc tgtaataact attgaacccg ctggaatctt acctgtttca
     2641 tcttcacttg tgctagagtc atcactttga tatacataat cttctgctaa ttttccaatt
     2701 ccattagtac gagtttcgtc tgcattattc attgtgccaa tttctatatt atcacctgga
     2761 ggtcctatta tatctaattc tgcaacttct atattagact tattatttga gattagtttt
     2821 acatatctag cttggtatgt ccaaagttta ccatctttat taaatgtaac tctagcttca
     2881 ttatcttggt cttttcctcc accaactaaa tcttgtccat attcaaaagt tccttgactt
     2941 acatcttccc agttcttttt atcattactt acttgtattt tgtaattagt taaaggattg
     3001 tatgttgtgc tagtattctt tctaaagtta aataatcctt ttaatgagaa cttcctagct
     3061 tctgtctctg gttttgtata ttttagtcct actataggta atgtttcttt catgtctact
     3121 attatatatg gattttcctc tacatttata tcagggtctt tttgagggtc tttgttccac
     3181 tctgctttac ttattatctt tcctttatat gtagtatttg catcattatc ttttatatta
     3241 tcaatttcag gattttgtaa tggtccatgt gagtcatttt cagttctaac atcaccgtca
     3301 gaaacagtat ttgttatgaa tgaccatgct gatttattta ttttcccttc atctgataat
     3361 tttacagtac caacttcaaa ttcttctgtt ggatttaggt gataatcata tgcaactacc
     3421 ttatatgtaa atgctctgtt attaagagga gatatattat cagtaaattt agtcttacta
     3481 tttccttttg catccacaaa tccaactgtt ctgtatttta cctgtgttcc attttcacca
     3541 tctaaataat ttccatcact tcttattatt tcgtatccta gtatcttatc tttatcctta
     3601 tctacatcta ggtctataga tattttatta gatttaacta gagaaccact ttgtattcca
     3661 tcagaaaaac tagcacttac tttagtatct tttgccatac tagctatatt ttcatttaaa
     3721 atctttcttc tagcttcgtc atttacatat tgtatctttc ttgattcttt ttcgtagttc
     3781 ttactatcca ttatactgtt taattctggt gtaatttcta ctccccatgc cttaaagtaa
     3841 tctcttaaat ctttttcaac aacacttgat gccattgcta ctagcatttg gtcttttggc
     3901 aaactattaa ttgggtcact acttgaaagt gctctgtatt ttcttgaaat ctttgcatag
     3961 aatgtatcat tacttaaatc agcatctgag ttattcttta acattgaacc cgtaaaatca
     4021 tcatcataag ctagatgtaa ttgccataac attccaagcc tttcaaatac attgcttggt
     4081 atacctaagc tatttgaagt tacatgctca tatatcttat ccattgttga accttcaatt
     4141 cttgaatgtg tcttatcatc aaaggtctga gcaagtaaag caagtacatt gttactagtt
     4201 tcgctatatg tcatctttcc aatatctgta acatgtccta tctcatgacc tattccccat
     4261 ccaaataagt ttcctcctgt agcttttcca ctatcatcta tttggaaagg tactccattc
     4321 ataagccctg gaactgaacc atattctact cctacatgta atccagaagc atacataaat
     4381 gctccaataa acattctttg gtattttatg ttcatacgag attttggagc catatcattt
     4441 ttagttaagt taaattcatt atcatctaca gttccattac catctaaatc ttgtgtttta
     4501 aatactcctc tttctgagta aactaaatcc attatttgtt cccatgcaag catactatta
     4561 tataatctat ctacttgtgt atttaaatca gcatttcctt ttgatatccc ttgatataca
     4621 gctgttgcag gaacatttaa tgttacttta tcactttcaa tatctgtagt gtttaacaca
     4681 ccagtttttt ctgaatatcc atatgaatta ccaacatttg ttcctggata atatggttct
     4741 ccttttacag catctttata tctagctaat tcttctatat atgcttttat ctttttctta
     4801 gattcagaaa ctcccgcagg actcttatca tttattgttc catttagatt aaggtgtggt
     4861 atcttagtag ctcctgctac acgtactttt atatctcctc cacttggagt atcttcagcg
     4921 tatcttatgt ataaacttcc tccacattct atatctaaac tatgaagttt gcttaattga
     4981 attacatttt ttccagtgtt aagatttatt tctccactct tatatgcacc agattctcca
     5041 tagtactgtg tatatatcaa cttaggagtt tttccacttt tacttccaac atatactgtg
     5101 atttcatctc ctgctctagc agctactcct aatgcctgcc agtcattttg catacctaaa
     5161 ttattggaat ttacagtata ctgtccgttt ttatctttat attttcctaa tttatttatt
     5221 tcttgattta cagtagttac atcagtaagt gtggctctat cattatataa gtcttgagct
     5281 aattttaatt ctctctcaat aactgtctta tatggatgat attctccact agctttatct
     5341 ggagtattta atctatcttt taattcagtt attttttctt gagttacatc ttcttttaat
     5401 tcaacttgta ggtcatccat aaatagattt cttacatcat cttctatact gtcatactca
     5461 taaaacttaa gttctgatat attagactta tatgaatagg atgaacaaac acttacttgt
     5521 atcttggtag cagttattgg ttcttttaat ctaaccatta catacttatt attatttaca
     5581 gggtctgtct ttgtttcaaa aggaacatcc cccagattgt gtaattgacc attttcatcc
     5641 caatatcgta cctcaaagtc atttattgtc ttatcagaaa catcaaaacg aggtgtagcc
     5701 ataaaagtat ccatagtata agatttatca aaagttatta ttggtcctct attcgttccc
     5761 tcagctgcat tatatgttgg gaatgtccaa tgtgttgtaa agtccccatc tactacattg
     5821 aatttatcaa atggattttt atcactatat tcacttttgt catatcctgc tggataagta
     5881 acatctacaa tgtgatttgt tggtattcca aatccaccat tctctttagg agtattaatt
     5941 aatctatagt taggtgttgt tggtgcatcc atgctttcag ttgtacctat atatgtttta
     6001 gacattccac tagttcccaa gtggttagta gctgtcattc taacttcata tgttgtatta
     6061 tccttaagac cttctatctt tgaacttgtc ccacgaataa gcttatcatt gtattttatc
     6121 caagacccat tagagccttt ttctttatag tacaagtcaa aatctttagc ttgtttatga
     6181 tttttccagc ttacatcaag agatttaaat ttacctttaa catttatacc ttctggtggt
     6241 tctggttttg tgtctggaac aacttgaaat tctaatatac tatctgggct aaattgtata
     6301 ggtttatagt ttgaatctac attttctggt actccgtcta agttttctgg tgttgcatct
     6361 ttataaccac tagaccaatc tccatttaaa gattgtatgc taaccctata tagtccatat
     6421 gcttctatat ctctaacttc tattgtattt ttactggttt gtaatttttt agtagataat
     6481 acttttccct tactatcaat tttatctagt ataagttcgt atgctgatac atttacttca
     6541 ttattccaat aaaaagatac tttttcattt ccaacagcag tgctagtcga tattttattt
     6601 attttaggta tattcatctc tggctttggt atttctttat atacattgtt taaaaattca
     6661 acttttgata tttctgcaag atttctatcg tttgctgttg tagctgttat ttttatagtt
     6721 atctttttta ctgctacttg tttaccaaga tttattacta tatcactatt ttgaacatct
     6781 gcatatgttt ctaatgttga cttactatat gtagatgttg tagagttatc atctttactg
     6841 atattaccct cttcttttgg agtatcttca tctgaattag gtttatccat tgatgaattt
     6901 tctttatcat tatttttatc ttgattggta ttagagttta cttcttgttt atcgctattt
     6961 tcctgttgtt catcattatt ttcatcttta ttatttgagt tattatcagt ctggtttata
     7021 ttttcatctt tattatttac ttcttcttga tttacttctt cttgttcgtt atttacttcc
     7081 tcttgttgct cctcatcttt taagtttttc atatattctt tgttttcata aggaatctgt
     7141 tgaacattac catctttgtc agtaacctca actattcctt ttgctggagc agtaccttct
     7201 ggagctttta tattgatgac ttccatatta agtgcttctg ataaagctat atccattact
     7261 gctggttttt cctcagatat ttcatcattt tttgaagata ttgtaactcc attattttct
     7321 ccactaaata aattttctac attaccatta atatctacat cactatttcc ttttaattca
     7381 accttacttg tatctactat aggattggta gatactatac tttctaggct ttttgcatct
     7441 tcactttgtc ctaaattttt ctgtacataa tctaagtcaa caatatctac ctttccatct
     7501 ctatttaaat caaattctct tttatttgaa tctatattct ctaaaacctt attataatca
     7561 ctcttatcta ctttaccgtc tccatttaca tcacccatta agaacaattc ataatttaaa
     7621 ggtttatttt tattatctac acttgctcta ttgcttaata agactctttg tgaataactt
     7681 gatatatcaa tgtctttaat ttctttgttc ttaaatccat ctccagagac ttctacattg
     7741 tattttccaa caggtaaatt attaaataca atattataat atgatatatt ctcatcttta
     7801 ttttttattt cacttctact tgcagataat ttttttatag tatattctat attatctgtc
     7861 ccaacattta ctgttcctga atctttttct ccaagcttta ttattccact attgttacta
     7921 tcatctttta atcgtaactg catattagtc atactttctg aatcgctatt ttttattggc
     7981 agtgaaaaat ttaaatctac ttcaagactc ccccttaact tttctgtaac tgatttttca
     8041 actgccctta gcttcccctc taatataggt tctgcaaaaa cgtttagtgg tgcactacac
     8101 atagatactg ctagtacaca agatattgcc tttttcatga aataacaatc ctcccttaat
     8161 aaatatctaa tttttcatga atttaaatac tataagtttc agacaataaa aaaagacact
     8221 caaagagaat cttaattata aaataaaaag actttactct ttttagcaac tggctgatat
     8281 ggctttaaaa gctttaatcc ctatagtttt gcgtcattag atttccctaa ttttgccatt
     8341 taattttcac tactttctta cccattttat actatattta aactttttaa tacaattttt
     8401 ttagattaaa ttataaaaaa ataacattta tattaattta ttaatataaa tgttattttc
     8461 cattataatt taattattta tatagcttcc ttacaagcat aattttgtgt atattttctt
     8521 attctttata tcttccataa aattcatgtg tagcatatag attcttatct cctgttatag
     8581 ctataccaaa tcccattatt tcataccctt tatgcaacat gttagttcct tcttctggat
     8641 ttgtcttcca ctcattaaaa ataaagtttc ctatatcatc tgcatctcta tttgtatata
     8701 caggtttatc tggaatttta tatttaatta tattttcacc ttgaactgct atatatccag
     8761 gtttaatctc actccaatct aagtatttca aaaaagtaga atatgaattt tttccattta
     8821 tcgtatgaga taaagtcttc ttatttgcca ttaaattaga ccaatcattt gctaaaccct
     8881 ctaatctgct tgctacagat aacgctctta ctccattctc ttttctatac tgctttgtaa
     8941 gagcatatac tttacccttt attctctctt taaatgctct atcatttgga ttgtaatata
     9001 aaccttgttg atttggtgaa gcttgattta tacattgctt gataacattc tgatttatgc
     9061 ctcctagtac agtcaatttg tctgcaccac ttaaaatact cttgttactg ccattttcaa
     9121 ctaaaactac aggagcattt tttgctattg tagaggcagc caaagcgtct gttaattgta
     9181 agcctttact tagataaaat tctttactat ttttataaaa ctcttgtata actatcttat
     9241 tagtttcaaa tctatctgtg ccacccaatc taatagaatt tgtgctctta actaattcgt
     9301 cgctgattat ttcactagaa ccaagcgcat aactctttaa gcctgtcgtg tcaaatccca
     9361 cactatttcc atctgtaagt attataggta ctccatctct agcagctact ggtgatgcac
     9421 ttatcgcatc tgcttctcct gtaaatccat tggctataat tactttatct attggcttaa
     9481 tttctttgat tttttcagct atttttatac ttgtatcaaa tctattttca ccaaagattc
     9541 tttgtacaac cttctttttg gatagtaact gattctcaac atttttactt attgttgatt
     9601 ctgagcctat tatatacaca gtctttgctt tgtttaatct ttccatagtt gtgtttggaa
     9661 tctgattttg ttttgtcatc aaaataggcg catttaaggc tccagctaaa ccacttgcac
     9721 ttagaccatc tgctaagcta ttatctgagt tgattagtat tgctgtattg tagttttgct
     9781 tatctgctat ttttgctgct gtctcatatc tgtcattccc ttttatttgc tcaactgatg
     9841 tcaacgcatt taccatagga gtatttacca ttactaaaaa tagtgtaagt cctatagcta
     9901 atatcttttt actattcttc atattatttt ctacccccaa tgtacttttc atatttttta
     9961 ttagtactca tacttatttt taatcaaaag ttacaatttt gttaccatat tttatatatg
    10021 ataccatagt tatccataca actcaaacaa tatacctaaa gtttttattc tctataaatt
    10081 caaaacatta taatttattt tatttaatta agttataagt tcaaaataat ttatgttaat
    10141 aagatgttta atcattataa gaagtatctt tttataataa tttttgcaat atgaatttct
    10201 caacattata atcaaaaaat aaaataaggt atctcaatct aattctaaat gagacacctt
    10261 atttttatta ttttatcttg ttatttgtat attttataat atctacacta tgtcttacat
    10321 attaacgcat tgtataatca tatattatct aaacaaactt ttaatattaa ttcctatatc
    10381 ttattagttc ttagtaaata agtttatttt ttctgctatt ttttcaatag cgtttttagc
    10441 tattccttca cctatttgta ctaacttagt agcattctta agtcttaact caactacttc
    10501 ttcttgtgat ttagaaagtt cttctgtagt taatactatt ggagcctttg aactagctgc
    10561 aagtggtgct gctgtaagtg catcaactaa ttgtccattt ccacctacat aaccatcttt
    10621 tgctacatat gctttagttg cacctgcata gtatttattg attactttag cattagtatc
    10681 ttttctattt tctccagcta atctttcaac tttattattt aaatctatat caactaattt
    10741 gtcttcaact tcttttgata cagaattttc tccacccact atttctaatt cttttccttt
    10801 taataatttt tcagcatttg catctaattc gttacctgta actattattg gagcaccaaa
    10861 ttgagcagct ctagctgata tactcatagc atcagcttct ccatttccac ctactacaaa
    10921 agcagtctta aatgtatctt ttaattgttt tgctatttct aaagaagttt caaatctatc
    10981 ttctccagaa actctctcaa ctttacttac acctaattta gaaagttttt cttcagtttc
    11041 ttttgatact ttagattctc cacctactat atatattttc ttagaagata gattacttcc
    11101 aagtactctt aatatttcag cttctatttc tgatggtagt gaatcttttt tagataataa
    11161 tattggtgca tttttttgag aggcaagtgg tgctgatgct aatccatcaa ctatagcatc
    11221 ttctccaact aaaattatag cttctgcttc tccatctttg aatctctctt tactaacttc
    11281 tactgctgtt gtaaatcttg aatcaccaga taaaacttct acttttaatt cttttccacc
    11341 ttttacatca gttaatactt tgtgtaagtc tctaactaac ttatggtttt tacttgaaac
    11401 acttattgtt tctggctttt catttgcctt gcttaaaact atatcaaagc ttgatttttc
    11461 tggtttatct ttatcatcac tatcttcttg ttcttgagta aggattgctt cattttcaaa
    11521 tgttaaagca tatccatttt taactttatt aactatttct cttcctaatg tagttaatct
    11581 aattccatca aataattctt ctgctgatat gtcttgtaaa tctgcgtttt taactgttat
    11641 cgtatgtaat tcttttgaat ctatgtcact ataactcttt tcataacctt caaaagtacc
    11701 ttcttctgat gttatcactt ttgagaaatc taaatgttgg tctcctacat ttaatgtaat
    11761 aacatttgct gaatcttttg ctctttttac ttcaactgta tttgtagatt ttatagttgc
    11821 tgttaacttg ttatcagaat cttctgctaa agttgcattg taagcattaa ctgcatctac
    11881 tatttcttga gcagttttgt agttttcaat tttatagtca actacttttc cacctaacac
    11941 ttgatgtcct ttatcttgaa tagtaacttt taaactttgc ccttctgtta aagagtttat
    12001 cttattttgt aattgagttg cattagttaa gtttacattg tctactttta tatcgtaaac
    12061 tctatcattt acatttgctc ctgcttttgt atcttcaaac ttaacttcta atgcttttct
    12121 aacctcttcg attagtttag cagaatcttt cgcacttact gtgtaatttt tatcaacatt
    12181 ttctgtcaca gtattgtctg cgaatattgg tgctgctgca ctcataactg tagcacctgc
    12241 cattactatt gccatacttc tctttttgtt gcttaacata tttatgtcct ccgaatatta
    12301 ttttttattt tttatattcg tatttcccac acataaataa tattatatat aatattattt
    12361 ttcaatatat tttatgtgtt tacataattt actaacacaa acactaataa tatcttcttg
    12421 aaccccttcc ccctgcttag ctctctataa ttatgctcaa agatagaaat cctattttat
    12481 agtgattttc tactaaacaa tcatatacta acaaaagtat tcaaactcca tttttatata
    12541 ctactatgca ctaatttttg ctttactctt attacttaaa tatatatcac taaattaata
    12601 tctatctcca tatatt
//
LOCUS       DAEHWM010000104        12226 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.107, whole genome shotgun sequence.
ACCESSION   DAEHWM010000104 DAEHWM010000000
VERSION     DAEHWM010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 12226)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12226)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12226
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.107"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(33..476)
                     /locus_tag="KNP36_003143"
     CDS             complement(33..476)
                     /locus_tag="KNP36_003143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874993.1"
                     /translation="MKKNMLYVGIIYFICGILLVLLATFTEFSFEAFIWGLSGAALGP
                     GVCMILQYMYWSKPERAVDYEEKIKNQRIEMNDERRIMLRDKAGRITNQIMSYVLVIL
                     IFIVSILSVFSVMVISKWVLVVLGLLILFQFICSVVVYNKLDKKL"
     gene            complement(479..676)
                     /locus_tag="KNP36_003144"
     CDS             complement(479..676)
                     /locus_tag="KNP36_003144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004631111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0874994.1"
                     /translation="MKNRLEEIRKERGIKQEELASILQVSRQTIGSLENGRYNPSIIL
                     AFKIARYFDMSIEEIFIYEEE"
     gene            complement(868..1734)
                     /locus_tag="KNP36_003145"
     CDS             complement(868..1734)
                     /locus_tag="KNP36_003145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0874995.1"
                     /translation="MEWINKLNQAITYIEENLESGVDYAEAAKIACCSTFHFQRMFSY
                     IAEVPLSEYIRRRRMTKAAFELQNSNIKILELSEKYGYDSPTSFNRAFQNIHNISPSA
                     ARAKGVVLKAYPKMTLSIYVKGNIEMQYRIVEKKGFRIVGIKESMNMIVEECFEKVPK
                     LWAKCIKNGTIDKLSELINNEPCGLLGVSVCTNSKGLDYYIAAPTDKPVLEDTHEYLI
                     PSGTWAVFECVSPMPNALAIQELQKRIITEWLPSSGYVYANLPDIELYPNGDINAPDY
                     TTEVWIPIQKPS"
     gene            complement(1960..2829)
                     /locus_tag="KNP36_003146"
     CDS             complement(1960..2829)
                     /locus_tag="KNP36_003146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0874996.1"
                     /translation="MDYKTIILNRKSVREYKNTDIKEEYLSEIKKYSESCKKLVPEID
                     VDVRIMNRSEVFNNLDKVAGYKGNMIDSPSYIIILSDIKDNYIENSGYIGESIIFKVT
                     ELGIGSCWVTFEDGKKVKEKLGINSDKEVTGIIAIGYGENVSNAKVLNATKTGQNYSK
                     SDMQVVTDKGSTRLGVEDVVYMNEWGNVASIEILEERALLDAFHYARLAPSTLNRQPW
                     RFIVDGGTVVLAVRKDGHTNLYEEKIDIGIVMLYFATIISATMFDLKWNLGTPDKDYK
                     VPEDYKIVGYCNI"
     gene            complement(3335..3556)
                     /locus_tag="KNP36_003147"
     CDS             complement(3335..3556)
                     /locus_tag="KNP36_003147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874997.1"
                     /translation="MNVNNHKCPECGEHSKKFEIVEENEDCVIFECYTCGTISILKYC
                     ENCKEFVFVNIPNNVETYEYCCGKCNNKI"
     gene            complement(4057..5037)
                     /locus_tag="KNP36_003148"
     CDS             complement(4057..5037)
                     /locus_tag="KNP36_003148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0874998.1"
                     /translation="MGDTSRFYESVKNKYPKLKDGTRVHLWPKENIIIGPIYDEEDGY
                     KKSIGNVDSLSWKQIVILAECDGKNTTDDIINILSNRYRNIHNMKEKVMEFFMFYENV
                     YLTFEDDIQTLSSVFEITGNKSYITPLYFTIEIDGDNNTNDYFSEITSLLNCMYEKGC
                     RFIEVIGEDILKNKSMREIFQYMLDHFDLIVVTKDSFTIDRSLIKELDNYRHKVIWKV
                     YSKNDDTRIKLKEDIKITSLIKRGHTVVRGDREKAIKIEDMRFKDTKERFSKYGAEWS
                     HLYISSDGSVKSYSFQKDKRIYLGNIFNNSVEEIFLEMQNKIDKLEIVYQ"
     gene            complement(5201..6073)
                     /locus_tag="KNP36_003149"
     CDS             complement(5201..6073)
                     /locus_tag="KNP36_003149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0874999.1"
                     /translation="MIIKVSMTVLVLILLYILYKYETQHIETTEYTIFNKKIPKEFDN
                     FKIVQVSDLHNKVFDKNNKVLIDKIESLNPDVIFITGDLVDGENKNFQVALDLIDNLV
                     EKYEVYHIIGNHEQKSLIKKYKHLYKDYFKELYSKKIINMENESVRIYRGNSHLNLYG
                     LIIPLECYPYLFANSKKLELSDNFVEDNLGKVNENEYNILLAHTPFFFEKYAKWGADL
                     VLAGHVHGGIIRIPFVGGVLSPNREFFPKYDWGKYEKDNSTMILNKGLGGSKVLIRLN
                     CKPEIVKITLKYEK"
     gene            complement(6237..6788)
                     /locus_tag="KNP36_003150"
     CDS             complement(6237..6788)
                     /locus_tag="KNP36_003150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888896.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0875000.1"
                     /translation="MDNKFPNVGENLRLLRQEMGISLDKASKMTGVSKAMLGQIERGE
                     SSPTVSTLWKISSGFKINFTTLLNENTNTYEVIKKEEVEPIVEQKGNMKLYPIYPFSP
                     QRRFELFIIELEENCTHVSSTHSHVLEEYVLVIEGKLDLNVDGKTYILESGHSIRFDG
                     TLEHIYKNLNKGKTIFHNIEVYR"
     gene            complement(6808..7710)
                     /locus_tag="KNP36_003151"
     CDS             complement(6808..7710)
                     /locus_tag="KNP36_003151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HBF0875001.1"
                     /translation="MSKKGRVVKVQHFSVNDGDGIRTTIFLEGCKLKCKWCSNPDSWS
                     NIVKLGVMKDKCVSCNRCIDVCPQNISSLFDRAQINNKCDLCGECIKVCLKDAICIMT
                     EEMSVEEIVEEVEKDFIFFFESNGGITFSGGEPTLQIDFLRELVDIFYDKGINIAIET
                     CGYFDWNKVNDVFEKIDHIFVDIKSMDDNIHKEYTGVSNKIILDNICRLSKLNKSMVI
                     RVPIIYGVNDSEENIRNTALFVKQNVPGGKMELLPYHKFGIDKYKALGLEDYIYEFDE
                     ICNNHMLKLKEIVELTGVKIIEYK"
     gene            complement(7725..10097)
                     /locus_tag="KNP36_003152"
     CDS             complement(7725..10097)
                     /locus_tag="KNP36_003152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase/glycerol dehydratase
                     family glycyl radical enzyme"
                     /protein_id="HBF0875002.1"
                     /translation="MSQTNRIEAFRQEYINSKPMICCERARIFTESHKKTEGEAICIR
                     RAKAFLETCKELPIKIFENELIVGTAGKFRRTGILTPEFSWQWVDKEMDTFDKRTQDP
                     YVISKEQIEFIRKEIFPYWKGKSLEEVFLARIPEDTAKILVDTGIIDNDSKWRQAVGE
                     VTPDYQDILFVKGYKGIKEDADKKIKELDISVSENIEKIDFYKSVSIVAQGIMTLAQR
                     YSNLAKEMSKQETDEKRKLELIKISEICMNVPANPPTNFYEAIQFVWFVQLGGILSEN
                     PLALNLGRFDQYMYPYYENDAREGKITESEAQELIEALWIKLSEWVWTISANTANYFA
                     GYNQFQNLTVGGKKRNGTDGTNDISYMCLKATESVKTHQPGLSVRVSQGAPDNFVMAV
                     AKLVKQGTGFPAIHSDSAGAQMLLQDGYDAEDARDWSNCGCVVPHFRKTGQWTSAVNI
                     NFAAALEYAMNEGKSRLTGEKMGLDTKNITEFTSFEELKDEFLKQLAYLVKSSVIGTT
                     VAQQIHKEMVPRPFLSTCVDGCLDKGVDLSKGGAKYNIGPVLTGIGLGVVSNSLAAIK
                     KLVFEDKVTTLEELTKALNNDWEGYEELRKLALDVPKYGNDNDYVDSLAIEVSDFYYT
                     ETRKYKDIFGSKFNSAFMGISNYVPTGKIVGATPCGRKATKPLTEGVSPFVGTDTTSP
                     LAAMKSASKINHDVHTGGTLLNLRLNQDLVETERGLRNLTSMIKSYFALGGFHVQFNT
                     ISNDTLLKAQENPEEYKDLLVRVAGYSTQFVNLSREMQDAIIARNSHSNF"
     gene            complement(10318..11007)
                     /locus_tag="KNP36_003153"
     CDS             complement(10318..11007)
                     /locus_tag="KNP36_003153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0875003.1"
                     /translation="MKVKRNINRVAIIVALNLSLALMVGCMSPVSDKNLSSSEQISKD
                     SLKEQVEDKKDESIELFNNYSQKINDAKGREEVKKDLSQRFSKAIIDSGYSITNSKSD
                     GSFVVSINGAEKPPEKNIRSLFYSMSEDDKEGKVTIDILCAKEYPEDDKLSESDKYVK
                     FIYNLFKSLTDTNLTEKEIFSMVEEDFNKGVGVVELPYMKDIHVEVNKVKQSTKVLKL
                     SLVYKFDISNH"
     gene            complement(11248..>12226)
                     /locus_tag="KNP36_003154"
     CDS             complement(11248..>12226)
                     /locus_tag="KNP36_003154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0875004.1"
                     /translation="ESIKIQIYSNLIIILIYLIFSFFRKSIKLISQDKRNYVYLLFAL
                     LVNTMNMLVNYVLKKLERFGSLHSEGYYFDNFVNPKLVGASSIFLILLFKEIIKENRL
                     KSQAELIKNKLDMQYAHYLSIQESHMRVKKLYHDINNHIYCIDNLRNNSKEINEYVNN
                     LKDEIKTFKYIYNTGNMILDIIINEKSEVCLKKGIKFTCSINFSKVNFVKPIDVSSIF
                     SNILDNAIEACDKIVDENINKYIRIKGTITRSFFVLKCENSKLNQLTFNKNILLTNKM
                     DKFVHGIGIQSIKSSLQKYNGELLFENSIDKFILNIYIPLDQDTDSWGD"
BASE COUNT         4013 a         2146 c         1165 g         4902 t
ORIGIN      
        1 ttatataatt ttctatttta tatcataact tattacaact ttttatctaa tttattgtat
       61 acaacaacac tacaaataaa ttgaaataaa ataagcaatc caagaacaac taaaacccac
      121 ttgcttatta ccattacaga aaatacactc aatatagaaa caataaatat aagaattaca
      181 agaacatagg acatgatttg attagtgata cgtccagctt tatcacgtaa cataattcgt
      241 ctttcatcat tcatctctat cctttgattt tttatctttt cttcataatc tactgctctt
      301 tcaggtttac tccaatacat atattgaaga atcatacata cacctggacc taaagcagct
      361 ccagataatc cccaaataaa agcctcaaat gaaaactcag taaatgtagc caataaaaca
      421 agtaaaattc cacaaataaa atatataatt ccaacatata acatattctt tttcattttt
      481 actcctcctc ataaataaat atttcttcaa tactcatatc aaagtatcta gctatcttaa
      541 aggctaagat gatagaagga ttatacctac cattttctaa tgaacctata gtttgtcttg
      601 atacttgcaa aatagaagca agttcttctt gttttatgcc tctttctttt cttatttctt
      661 ctaatctatt tttcacatct atcccccttt aatatctcaa ctacggaaag tctactttcc
      721 ataattatac aactatattc catttatgta aagcttactt tccatattta caaaaaaata
      781 acagactatt ttcagcctgt aattttagaa tttcatgttg tttattaatt ttaatgttat
      841 ttattaattc catattattt attaatttta acttggtttc tgaattggaa tccaaacttc
      901 tgtagtataa tcaggagcat tgatatcgcc attgggataa agttcaatat ctggtaaatt
      961 agcatacaca tacccagaac ttggtaacca ctcagtaata attctttttt gcaattcctg
     1021 tattgccaga gcatttggca ttggagaaac acattcaaat actgcccatg tgcctgatgg
     1081 tattaagtat tcatgagtat cttctaatac aggcttatct gttggagcag caatataata
     1141 atctaaaccc ttactatttg tacacacact aactccaagc aatccacaag gttcattatt
     1201 tattaactct gaaagtttat caattgttcc attttttatg catttagccc acaacttagg
     1261 aactttctca aagcactctt ctacaatcat gttcatactt tcttttatac caacaatacg
     1321 aaaccctttc ttttctacaa tacgatattg catttctata tttcctttta cataaatgct
     1381 taatgtcatc ttaggatatg cttttaaaac aacacccttt gctctagctg cagatggaga
     1441 aatgttatgt atattttgaa aagctctatt aaaagatgtt ggtgaatcgt aaccatactt
     1501 ctcagatagt tctaaaattt tgatgttact gttctgaagt tcaaatgcag ccttagtcat
     1561 acgtcttcgt ctaatatatt cagataatgg tacttctgca atatatgaaa acattctttg
     1621 aaaatgaaag gttgaacaac atgcaatttt tgctgcttct gcataatcca ctccactttc
     1681 gagattttct tcaatataag taatagcttg atttaattta tttatccatt ccatttgata
     1741 ttacctccaa gcaaattata cagtttaata aaataatata cctctctatt catgcacaaa
     1801 attgtaagca tttaaattta taagcatttt tcaatcaata caataaatat aaaaattgta
     1861 ttatacaata aaaaagttca ataacattat attataaaat gttattgaac tttttataaa
     1921 aattaattta agtgtagtta aattaagtat tacactatct tatatattac aatatcctac
     1981 tatcttatag tcttctggca ctttataatc tttgtctgga gtacctaaat tccattttaa
     2041 atcaaacata gttgcactta ttattgttgc aaaataaagc ataactatac caatgtctat
     2101 tttttcttca tataaattag tatgaccatc ttttctaaca gctaaaacta cagtgcctcc
     2161 atcaactata aatctccatg gttgtctatt taatgtagat ggagctaatc ttgcatagtg
     2221 aaatgcatca agaagtgctc tttcttctaa gatttctata cttgcaacat ttccccattc
     2281 gttcatataa acaacatctt ctacacctag tctagtagac cccttatctg ttacaacttg
     2341 catatcagat tttgaataat tttgcccagt ttttgtagca tttaatactt tagcattact
     2401 tacattttct ccatatccaa tagctataat tcctgttacc tctttatctg aattaattcc
     2461 aagtttttct tttacctttt ttccatcttc aaaagtaacc caacaagaac caattccaag
     2521 ttctgttact ttaaagatta tactttctcc tatgtaccct gaattttcaa tgtaattatc
     2581 ttttatgtca gataatatta taatataact tggagaatct atcatatttc ctttgtaccc
     2641 tgctacttta tctaaattat taaaaacttc acttctattc ataattctta catcaacatc
     2701 tatttctgga actagtttct tacaagattc tgagtatttc ttaatttcac taagatattc
     2761 ttctttaata tctgtgttct tatattctct aacagacttt ctatttaata tgattgtttt
     2821 ataatccata attttatcct ccccaaacta gtattgtctt aattatatac ccattaatat
     2881 attattttac tcatttattt aataaataaa gattacaatt ttgtaattat tatttattaa
     2941 taatattcca cttttacatt aataatgacc agttgtgcaa aatccattgc caaccaccaa
     3001 ataaaaacat attataaagg taatataaaa taacaaacaa atcttaacaa aaaattaaac
     3061 tttttttaca cgaaagaagg cttcccgttg ccttctttat ttttataaaa aaataagctg
     3121 tttctaaaat gatttcacat ttttgaaaca gccaagttat tctataatga caactataat
     3181 ttgaggatgt gagggagagt tgtcattata aatttagggt aattatatta tgttttaagc
     3241 tagttctttc tatatttata taatacattt tatatatgaa ttttatatga gattggtata
     3301 aatgatatat gaaattacat atgtttatat tatattaaat tttattatta cattttccac
     3361 aacaatactc atatgtctcc acattatttg gaatatttac aaatacaaat tctttacagt
     3421 tctcacaata ctttaatata gatatagttc cacaagtgta acattcaaat attacacaat
     3481 cctcattttc ctctactatt tcaaactttt tactatgttc accacactct gggcacttgt
     3541 gattatttac attcataaat actcctcctt attagtatag ttacatgtca aaaacttaat
     3601 taatgtattc tatattactt attatatatt ctataataaa tcatattcta atataataaa
     3661 acaaattaaa taaaaaaaaa ccataaattt taaatttatg gattaattct tgtaatgata
     3721 actctatttg aggatgtgag ggagggttat cattacaata gggtattata ttatggtttt
     3781 taagctagtc tttctacacc tcatatgata catatgctat atgaatttta tatgattttt
     3841 acataaatat tttatgaaat ttaaattttt tagtcatttt gaaatttgta aaaagttctc
     3901 taaaaatcca cagcatcata aacagccaaa atttaagtag aacatcataa aaaaatttgt
     3961 ccaataattt taacaagtaa tctcacctca ttataattat tgacacaaac ttaaataaac
     4021 aatctataaa tcttctataa atcttaaact ttccccctat tgatacacaa tttctagttt
     4081 gtcaatttta ttttgcattt ctaagaaaat ttcttcaaca gaattgttaa atatattgcc
     4141 taaatagatt cttttatctt tttgaaatga ataagatttt acactaccat cagaagaaat
     4201 atataaatga ctccactctg ctccatattt tgaaaacctc tcctttgtat ctttaaacct
     4261 catatcttct atttttattg ctttttctct gtctcctctt actacagtgt gacccctttt
     4321 tattaaactg gttattttta tatcttcttt taatttaata cgtgtatcat cattttttga
     4381 atatactttc catatcactt tatgacgata attatctaat tcctttatta agcttctatc
     4441 aatagtaaaa ctatctttag ttaccacaat taaatcaaaa tggtctaaca tatattgaaa
     4501 tatttctctc atacttttat tttttaaaat atcctcacca ataacctcta taaatctaca
     4561 gcctttctca tacatgcagt tcaataaact tgtgatttca gaaaaataat catttgtatt
     4621 attatctcca tctatttcta tagtaaagta caaaggagta atgtatgatt tatttcctgt
     4681 tatctcaaat acacttgata gtgtctgtat atcatcttca aacgttaagt atacattctc
     4741 ataaaacata aaaaattcca taactttttc tttcatatta tggatatttc tatatctatt
     4801 ggataatata tttattatat cgtcagtagt atttttccca tcacattcag ccagtataac
     4861 aatttgcttc caacttaagc tatccacatt tccgatactt tttttatatc catcttcttc
     4921 atcataaata ggaccaatta taatgttttc ttttggccac agatgaaccc tagttccatc
     4981 ttttaatttc ggatatttat tttttacaga ctcataaaat ctacttgtat cacccatgat
     5041 tctttactac cccccatagt ttaaatattc tatgctaaaa atagcacttt atttttatta
     5101 attcaacaat tattcaaaat tggtcattat atatgtttaa atggatttaa catcaacctt
     5161 atttatatgt tattgatgtt tatatatgtt atataaaatc ttatttctca tacttcaatg
     5221 taatcttaac tatctctggt ttacaattaa gcctaattaa aacttttgag cctcctaagc
     5281 ctttatttaa aatcatagtg ctattatctt tttcatattt tccccagtca tacttaggaa
     5341 agaactctct atttggagat aatacacctc caacaaaagg tattcttatt atacctccat
     5401 gaacatgtcc tgctaaaacc aaatctgctc cccattttgc atatttttca aagaaaaatg
     5461 gtgtatgtgc taaaagaatg ttatattcat tttcattaac tttacctaga ttgtcttcta
     5521 caaaattgtc acttagttct aattttttgc tattagcaaa taaatatgga tagcattcca
     5581 atggtataat taaaccatat aaattaagat ggctattacc tctatatatt cttacagatt
     5641 cattttccat atttattatt ttctttgaat atagttcctt aaaataatcc ttatatagat
     5701 gtttatactt ttttattaaa gatttttgtt catgatttcc aattatatga tatacttcat
     5761 atttttcaac caaattatct attaaatcta atgcaacttg aaaattttta ttttctccat
     5821 ctactaaatc tcctgttata aatataacat ctgggtttaa tgattcaatt ttatctatca
     5881 ataccttatt atttttatca aacaccttat tatgtaaatc actcacttga actattttaa
     5941 agttatcaaa ttcctttgga atttttttgt tgaaaatagt atattctgtc gtttctatat
     6001 gctgagtttc atacttatac agaatataca ataatattaa tactaatact gtcattgaaa
     6061 cctttataat catattctct tcctctttat tctattttgt taatattatt ataatgcttt
     6121 tatgtttttt ttaaaacaat aacatcatca catacatata aatcttttcg acattataaa
     6181 aataagttat ccttttctaa aattttcatt tattttagaa aaggataact ataaaattat
     6241 ctataaacct ctatattgtg aaatatagtt tttcctttat ttaaattttt atatatatgc
     6301 tctaaagttc catcaaacct aatagaatgt ccagactcta aaatataagt tttcccatcc
     6361 acattaaggt caagtttacc ttctattacg agtacatact cttctaaaac atgactgtgt
     6421 gtagatgaaa catgagtaca gttttcctca agctcaatta taaaaagttc aaaccttctt
     6481 tgagggctaa aagggtatat tggatataac ttcatgttcc ctttttgctc aacaataggc
     6541 tctacttctt ctttctttat aacctcatag gtatttgtat tttcatttaa tagtgtagta
     6601 aaatttattt taaatccaga tgaaattttc cataaagtag atactgtcgg acttgattca
     6661 cctctctcaa tctgtccaag cattgcttta ctgacacctg tcatctttga agctttgtct
     6721 aaacttatgc ccatttcttg tctcaataac cttaaatttt ctcccacatt aggaaattta
     6781 ttatccatgt taaaatcctc ctgatagcta tttgtattct atgattttta ctcctgtaag
     6841 ttctactatc tcttttaatt ttaacatatg attgttacaa atttcatcaa attcatatat
     6901 ataatcttca agccctaatg ccttatattt atcgattcca aatttatgat atggaagtaa
     6961 ctccatcttg cctcctggaa cattttgttt gacaaataat gcagtatttc ttatattttc
     7021 ttcactatca tttactccat aaataattgg cactcttata accatagatt tattcaactt
     7081 tgaaagccta catatattat ctaatataat tttattactt actcctgtat attctttatg
     7141 aatattatca tccatagatt ttatatctac aaatatgtgg tctattttct caaatacatc
     7201 atttacctta ttccaatcaa aatatccaca agtttcaatt gcaatattta tgcctttatc
     7261 ataaaaaata tcaactaatt ctcttaaaaa atcaatctga agtgtaggtt cacctccaga
     7321 aaaagttatc cctccattag attcaaagaa aaatataaaa tctttttcaa cttcctctac
     7381 tatttcttca acactcattt cttcggtcat tatacaaatg gcatctttaa gacatacctt
     7441 gatacactct ccacataaat cacatttatt atttatttgc gctctatcaa atagtgaact
     7501 tatattttga ggacaaacat ctatacatct attacaggat acacatttat ctttcataac
     7561 acctaatttt actatgttac tccaggaatc tggattagaa caccacttac attttaattt
     7621 acatccttct aaaaatatag tagtccttat tccatctcca tcatttactg aaaaatgttg
     7681 tacttttaca actctacctt ttttactcat aatctacctc ataattaaaa attgctatgt
     7741 gaatttctag ctattatagc atcttgcatt tctcttgata aattaacaaa ttgagtacta
     7801 tatccagcaa ctctcactaa taaatcttta tattcttctg gattttcttg agcttttaat
     7861 agagtatcat ttgatatcgt attaaattgt acatggaatc ctcctaaagc aaaatatgat
     7921 ttaatcatag atgttagatt tctaagtcct ctttcagttt ccaccaaatc ttgattcagt
     7981 cttaaattta gaagtgttcc accagtatga acatcatgat ttatttttga tgcagatttc
     8041 attgctgcta gtggacttgt tgtatcagta ccaacaaatg gagaaactcc ctctgtcaaa
     8101 ggttttgtcg cttttcttcc acaaggagtt gcgcctacga tttttccagt tggtacatag
     8161 tttgatatac ccataaatgc actattaaat ttagagccaa aaatatcctt gtattttcta
     8221 gtttcagtat aataaaaatc agaaacttca attgctaatg aatctacata atcattatca
     8281 tttccatact taggaacatc caacgcaagt tttcttaatt cttcataacc ttcccaatca
     8341 ttatttagtg cttttgttaa ttcttctaac gtagtcacct tatcctcaaa tactaatttt
     8401 tttatagctg ccaatgaatt tgaaactaca cctaacccta taccagttaa tacaggacct
     8461 atattatatt ttgctcctcc tttacttaaa tcaactccct tatccaaaca tccatctaca
     8521 caagtagata aaaatggtct tggtaccatt tctttatgaa tttgttgagc aacagtagtt
     8581 cctataacag aactttttac aagatatgct aattgcttta aaaactcatc cttaagttct
     8641 tcaaaagaag taaattctgt gatatttttt gtatctaacc ccattttttc tccagttaat
     8701 ctactcttac cttcattcat agcatattct aaagctgctg caaaattgat atttacggct
     8761 gaagtccact gtcctgtttt tctaaaatga ggaactacac aaccacagtt actccaatct
     8821 ctagcatctt ctgcatcata tccatcttgt aataacattt gtgcccctgc actatcgctg
     8881 tgtatagcag ggaaaccagt tccttgtttt accaatttag caactgccat tacgaaattg
     8941 tctggtgctc cttgactcac tctaacactt aatcctggtt ggtgagtttt tacactttct
     9001 gtagccttta aacacatata tgagatatca ttcgttccat cagtaccatt tctcttttta
     9061 ccaccaacag taagattttg gaattgatta tatcctgcaa agtaatttgc tgtatttgct
     9121 gatatagtcc atacccattc tgataactta atccaaagtg cttctatcaa ttcttgagct
     9181 tctgattcag ttattttacc ttctctagca tcattttcat aatatggata catatattga
     9241 tcaaatctac ctaaatttaa tgccaatgga ttttctgata gaataccacc taattgaaca
     9301 aaccatacaa attgtattgc ttcataaaaa ttagttggag ggtttgctgg tacattcata
     9361 catatctctg aaatttttat aagttctaac tttctctttt catctgtttc ttgcttactc
     9421 atctcttttg caagatttga atatctttgt gccaatgtca taataccctg tgcaactata
     9481 gaaacagatt tgtaaaaatc tatcttttca atattttctg aaactgatat atctaattct
     9541 ttaatttttt tatctgcatc ttccttaatc cctttatatc cttttacaaa caatatatct
     9601 tgataatctg gtgttacttc accaactgcc tgtctccact tagaatcatt atctattatt
     9661 cctgtatcta ctaatatctt agctgtatct tctgggattc ttgctaagaa aacttcttcc
     9721 aaagattttc ccttccaata tggaaatatt tcttttctta taaattctat ttgttctttt
     9781 gatattacat atgggtcttg agttctttta tcaaaagtat ccatttcttt gtctacccat
     9841 tgccaagaaa actctggtgt caatatccct gttcttctaa attttcctgc tgtacctact
     9901 attaattcat tttcaaagat ttttatagga agttctttac atgtctccaa aaaagcttta
     9961 gctcttctta tacagatagc ttctccctca gtttttttat gtgattctgt aaaaattcta
    10021 gccctttcac aacatatcat aggtttagaa ttaatatatt cttgtctaaa tgcttctatt
    10081 ctattagttt gactcattta aaatccccct ttggataata tatactacat ttttgtatgt
    10141 tataacatac tttaattata ttatactgtc ctttagcata aaatggaagc aaaataactt
    10201 attttttttc atctaccttg aacacctata tattaatact ttttttgtta aatttataaa
    10261 atctaaaaaa attttctatg atatattttc tatattgtta tagttatgtc taatatacta
    10321 atgatttgaa atatcaaatt tgtatactag acttagtttt aaaaccttag ttgattgttt
    10381 aactttgtta acttcaacat gtatatcctt catataagga agctctacaa cacctactcc
    10441 cttattaaag tcttcttcaa ccatagaaaa aatttctttc tcagttaagt tcgtatcagt
    10501 caatgattta aataaattgt atataaattt aacatattta tcactctcag ataacttatc
    10561 atcttctgga tactctttag cacagagaat atctattgtt acttttcctt ctttatcgtc
    10621 ttcagacata gaatagaata aacttcgaat atttttttca ggtggttttt cagcaccatt
    10681 tatagatact acaaagctac catctgattt tgagttagta atactataac cactgtctat
    10741 tatagctttc gaaaatcttt gagataaatc tttttttact tcttctctac ctttcgcatc
    10801 attaatcttt tgtgagtaat tattaaatag ctcaatagat tcatcttttt tatcttcaac
    10861 ttgttctttc aatgaatctt tactaatttg ttctgagcta cttaagttct tatcagatac
    10921 aggagacata caccctacca tcaatgctaa gctaagattt aaagccacaa ttattgccac
    10981 tctatttata ttccttttta ctttcataca caatcctccc atcacactaa ccgctctaaa
    11041 gtattattca ttgcactaga atatatttat attttcttta tattaaagat ttattattca
    11101 atacatatca ccttcctatc caattcttat aacttactat tagtaaaatt ataagctcct
    11161 taatacagaa ataaggatgt tatcttttgt tattaaaaga taacatcctt atttttttgt
    11221 atcaatacat atgtcccaac tggtaactta atcgccccaa ctgtcagtat cttggtccaa
    11281 tggtatatat atatttagta taaatttatc gatactattt tcaaataata attctccatt
    11341 atatttttgt aaagaagatt taatactctg aatacctatt ccatgtacga acttatccat
    11401 tttgtttgtt aacaatatat ttttattaaa agtaagctga tttagtttac tattttcaca
    11461 tttaagtaca aaaaatgacc ttgttatagt tcctttaatt ctaatatatt tattaatatt
    11521 ttcatccact attttatcac atgcttctat tgcattatcc aaaatattag aaaatatgct
    11581 tgacacatct ataggtttta caaaatttac ttttgaaaaa tttatagagc aagtaaattt
    11641 aattcctttt tttaaacata cttcactctt ttcgttgatt ataatgtcta atatcatatt
    11701 tcctgtatta tagatatatt taaatgtttt tatttcatct tttaaattgt taacatattc
    11761 attaatttct ttgctattgt ttctaaggtt gtctatacaa taaatgtgat tatttatatc
    11821 gtgatatagt ttcttaactc gcatatgaga ttcttgaata cttaaataat gcgcatattg
    11881 catatctaac ttatttttta ttaattcagc ttgagatttt aatctattct cttttattat
    11941 ttctttaaac aatagtataa gaaatatact actagctcct accaattttg gattaacaaa
    12001 attatcaaaa tagtatcctt ctgaatgtaa tgacccaaac cgttctaatt tttttaatac
    12061 ataatttaca agcatattca ttgtattaac taataaggca aataataaat atacataatt
    12121 tctcttatct tggctaatta attttataga ctttctaaaa aagctaaata taagatatat
    12181 aagaataatt attaaattac tatatatctg aatttttata gattct
//
LOCUS       DAEHWM010000105        11777 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.108, whole genome shotgun sequence.
ACCESSION   DAEHWM010000105 DAEHWM010000000
VERSION     DAEHWM010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11777)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11777)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11777
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.108"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(348..893)
                     /locus_tag="KNP36_003155"
     CDS             complement(348..893)
                     /locus_tag="KNP36_003155"
                     /inference="COORDINATES: protein motif:HMM:NF012798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HBF0875005.1"
                     /translation="MRVEPIENKKDIEKLKRYFKNKGKIRDLTLITLGLNIGFRIEDI
                     LKLKVKDVYKKREINIKESKTGKRIRKPINDSLKEILDIYCKDKPTNEYLFKSQKGEN
                     EAISTTQAYRIIKKASKACRIKLNIGTHSMRKTHGLHIFKDKGIEVAQRALNHANQID
                     TLTYIGVVQKQADDAIMKLNL"
     gene            complement(909..1157)
                     /locus_tag="KNP36_003156"
     CDS             complement(909..1157)
                     /locus_tag="KNP36_003156"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875006.1"
                     /translation="MEGTKRSYRKIPKLDLRKVKLADVFEKNEPGVFRVKESDEQLLY
                     DCLEETQNIRQEKHIAYAIRFRGKSVYCVFYESPFWDL"
     gene            complement(1513..2148)
                     /locus_tag="KNP36_003157"
     CDS             complement(1513..2148)
                     /locus_tag="KNP36_003157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009894454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBF0875007.1"
                     /translation="MIIGYERVSTRKQDNSRQERVLENEGIKFDKIYKDVITGATKER
                     EALSRMLVEVNKGDTVYCESISRLGRNLKDLIDIIDTLVQKGVRVKILKEGIDTNNNT
                     YKMLLGIFGAVAEMERETIQERTQQKIDQLKEDKKNTGEINTKSGKWFGRQKVTKELL
                     ETNKEFIKYYNKILDGSLKKNEVAKILNVGRTTLYEWIKIYEGGEIKRNRS"
     gene            complement(2738..3106)
                     /locus_tag="KNP36_003158"
     CDS             complement(2738..3106)
                     /locus_tag="KNP36_003158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004068822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875008.1"
                     /translation="MELDFKFIGQRIKIARIKKKLTQEVLSEKINVSPQHVSNIETGN
                     SSVSLPTLVAIANTLGVSVDELLCDTILSSKAVFENELEEVLRDCNEYEIRFITDIVK
                     ASKKSIRDIKLFQSNLNDRY"
     gene            3222..3554
                     /locus_tag="KNP36_003159"
     CDS             3222..3554
                     /locus_tag="KNP36_003159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875009.1"
                     /translation="MDIPKIPQTELKVMKFIWSKNDIVTSKEVAKAMELEYSWKMTTT
                     LTILSRLVIKHFLASERIGRMTHYTILIAKKDYKISETKRFLNDIHSNSLESLLNSLK
                     DCNITHKK"
     gene            complement(3702..4139)
                     /locus_tag="KNP36_003160"
     CDS             complement(3702..4139)
                     /locus_tag="KNP36_003160"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875010.1"
                     /translation="MRVKNIISIFVCALIIIMSVNVVSFAEQFNSSDIIFMEDGKEEI
                     NPFSVYILNGRCNLSFSNGKANVNASVVGKSGVTRTSIVTKLQELKGGSWVNLKTSTK
                     KTGGKTCSVLNSYSVTKGHTYRAVAIITAENESKTLISTSQKY"
     gene            complement(4208..4909)
                     /locus_tag="KNP36_003161"
     CDS             complement(4208..4909)
                     /locus_tag="KNP36_003161"
                     /inference="COORDINATES: protein motif:HMM:NF025643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4367 domain-containing protein"
                     /protein_id="HBF0875011.1"
                     /translation="MNKDKLDIEKLLYEQLPKIEEKILYELPCDEDIDYEFSIEFESK
                     MDKIIKENEKKVKKNTYKNLKKIAIVFIIILSSIVTITTIKTEAFPENLIRIMKKVYK
                     EFTDYNFINPHKSNVSFKYIEPKYISTGYKEVERIEEENYLSILYKDKLDNYIIYQMM
                     LYSRDVIVLDTEDAFVENIKFNNQYAQYVEKGNTQQLLWHDKNNIYMLSKELPTKKIT
                     KKDKKEFIKIAKNIK"
     gene            complement(4902..5447)
                     /locus_tag="KNP36_003162"
     CDS             complement(4902..5447)
                     /locus_tag="KNP36_003162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0875012.1"
                     /translation="MLIYLAIIDSKEERIKFEEIYIKYKKLMFYVANQILKDDVLAED
                     AVHSSFLKIIDNLDKVNDVNSPKTKGFVVIIVKRISINIYNRRKKEEISNINDDNYKF
                     SSLDLSIEKLGECSYLGEALKKLSETDLQVILLKYSHGFSIREISKLLNIKEVNLYKR
                     NKRALEKLKKILSEMEALSNE"
     gene            5583..6311
                     /locus_tag="KNP36_003163"
     CDS             5583..6311
                     /locus_tag="KNP36_003163"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875013.1"
                     /translation="MKSKRINKMLATTMTMAMLAIPAVTATSYAMESTGLGTEYTYNN
                     ESKQQEEWVKSFDTETGKEILLNKTTNEKVSEVYENVNGKLVKLSINEALEKFNLNEE
                     IITKSPKSIFGVSSVKKITGSARKISQDVSGGKQGATISIGNSTTVTESFTVGGTTEA
                     IKAAVRANAGFTWSKSLTRSVTTTHKVPAGKIGYVAFKPYYKEVRGTVNGILAGTSIT
                     QKIVAKSPLKAGKVCDGLEYLAYK"
     gene            6337..6585
                     /locus_tag="KNP36_003164"
     CDS             6337..6585
                     /locus_tag="KNP36_003164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004035436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875014.1"
                     /translation="MENKNMYLRVSLILAVLGFIILFFNNDLALSLKATYLADKGFED
                     IVENQILKNYSYMFLIIGGVLFSIGIYNLTKLKQINKK"
     gene            complement(6771..9380)
                     /locus_tag="KNP36_003165"
     CDS             complement(6771..9380)
                     /locus_tag="KNP36_003165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011572948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBF0875015.1"
                     /translation="MKIDIKQLIDIIKNANIDELYLRDIGVDTTQKRNVPCPIHGGKD
                     KNFQFDLNKRIYTCYSHNCVVGADIIELCRTYERFERPIEAILFLANKYNISLPINKS
                     KTNIKKTNNTIKNIYIKKKDINSFIEEKKQEAFKNNDIELAFEFECMTDKDKRKYYLD
                     NNIKIKSMLEKQNYSSYKADSIINIDKYISENLKGIRESIKHATEGKNVLMVAPTGSG
                     KTYSIINTLKELDIKALFIFPNSANVQQAIVEYKIAGAYDKIPTKHALEGNKLVAMTW
                     DKTEQLLKEDLSEYIIVIDEIHQTYTDAFRSKAIKSLNNITNKCRGRLDITATPSKLE
                     FEIYNKVIEYKQNIQTEYKVKLYDKINIGKVIEILNNSNNSMLLKDSISTLNYISKKV
                     NKKSGVVISDTKDTSKLYDRIVSYSDMEGYEVLLNTSVITAGVNINNPNVTDIIVIGE
                     KDVGKIKQYVARARGAKSINVHIFNSYKTTNEDSNVYSVEWCINENIKDVESLTNIYN
                     KASKRDLPYRAIGIDISPINIKNIDSNIYYDKKDMCYKTDKLYIKSNAYNNYYQTRTI
                     NSFKVLLEEYFNKIEIVETEKETKKIEEEIKEHEEAIKEFKKSAIEQLEGHKKYLVGY
                     SEIKKSMTSSNLLKYHHDMRIDNNICLKYYMEHDLYSLIINNNCRKTIDLFSDFVLDN
                     SYSIDLSWKLATMSDEKRNLFFEQINTTIYRKINKKYANSLLNDDNIGTYTYNYINFN
                     FGVGTSYTKEHLEALAVDLQTFLATKKKLTIKKISLILQSIFVIEVKQHRGVTGLPYK
                     YYKNILPNPVTDKKVIRVYTIKKHIDIEDIKKELGLIDNDLSIEHLVEARINKLLNAI
                     DETEKEVLLEGLI"
     gene            complement(9710..10012)
                     /locus_tag="KNP36_003166"
     CDS             complement(9710..10012)
                     /locus_tag="KNP36_003166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011572949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875016.1"
                     /translation="MLKDDLLRIGFDTYGVNLEDKLLENNEIYLNDKKESERIMNRLL
                     EILEEKEHKKMLIDFEEKVFGNSVIEKEYAYRMGVLDGLDLAEFIDLNKKLCLKRN"
     gene            10181..10384
                     /locus_tag="KNP36_003167"
     CDS             10181..10384
                     /locus_tag="KNP36_003167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003366523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875017.1"
                     /translation="MDIQINKLLENQNKTRYWLAKQIGMTHQNLTKLANNNTNSIKFD
                     SLEKICMALKCSPNELFGWEQDK"
     gene            10464..11009
                     /locus_tag="KNP36_003168"
     CDS             10464..11009
                     /locus_tag="KNP36_003168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011572951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875018.1"
                     /translation="MDRYTFDNLPIKEQIQYINNKLLEGNTLTNTCKDIGIGRTTIRN
                     RFKQHGYEFNPTKKLYISIIEVVELESSSKVVAGDTSNDNTLVDATNIDFNNILSKFN
                     DMNNKLNEVYSWYESQSSNKVVGADKLNIDDFKGNIVVRSYKVYEDIQKEFVAFCEAN
                     KKYRVQDIISQALRDFMDKYK"
BASE COUNT         3901 a         1821 c         1281 g         4774 t
ORIGIN      
        1 aaaaaaaaat aaccatacgc attgatttta cttaaattaa aagtgttttt cgagttgttt
       61 tttcacttag tttagtaatt ttgaaatatt ataatattaa gcttcaatat gtatctatta
      121 tcatttaata atcaattaat aatagatatt ttttctaaac aagataaaaa caatatctat
      181 accagtaata gcaatagata gaagtatata aaaaaatgta cgattactat aaactattac
      241 atttatttta gttatcttta tccattgcaa ttacttatac ataagcttat ttacttaatc
      301 attaactata aaatgtaaaa acaacaaaga aaatcataca tttttaacta taaattaagt
      361 ttcataatgg catcatcagc ttgtttttgt actaccccaa tataagttaa tgtatctatt
      421 tgattagcat ggtttaaagc tctttgtgcg acttcaattc ctttatcctt aaatatatgt
      481 aaaccatgtg ttttcctcat gctatgagta cctatattta attttatcct acaagctttt
      541 gaagcttttt taataattct atatgcttgt gtggtgctta ttgcttcatt ctctcccttt
      601 tgacttttaa ataagtattc attagttggt ttatctttac aatatatatc taatatttct
      661 ttcaaactat catttatagg ctttcttatt cttttccctg tcttactttc ttttatattt
      721 atttctcttt ttttgtatac atctttaact tttagtttta aaatatcctc tatcctaaag
      781 ccaatattta accctaaagt tattagggtt aaatctctta ttttaccttt atttttaaaa
      841 tatcttttaa gcttctctat atctttttta ttttcaatag gttctactct catttaactc
      901 actcctattt ataaatccca aaatggactc tcataaaaaa cacaatatac actttttcct
      961 ctaaatctaa tcgcataagc aatgtgcttt tcttgtctaa tgttttgagt ttcttctaaa
     1021 caatcatata agagttgttc atcactttct tttactctaa aaactcctgg ctcattcttt
     1081 tcaaatacat ctgctaattt tacttttctt aaatctaatt ttggtatttt cctataactt
     1141 cttttagttc cttccataat ttcccctctc atttttctat ttatataaat tattttaata
     1201 tatttttaca atccaaaagt ctctattttg ttcaaaatat gtagtttttt attacttgtt
     1261 aatttacaaa atcatttgat gtgattttat cattctatct actataccaa aaaaaatctt
     1321 attttcttaa gtaaatcaaa atttaatatt tataataaaa aaaagagcct aaaaaattag
     1381 actcttgttt gcaaaagcta ttaaattgta aagctttcaa taatataatt atactatata
     1441 ttttgttctt attttgtcta attttgttca atttttgttc aaaataataa cacttaaata
     1501 tattataatc aattagcttc tattcctttt tatttctcca ccttcatata tctttatcca
     1561 ctcgtaaagt gtagtcctac caacatttaa tatttttgcc acttcattct tctttaagct
     1621 tccatcaagg attttattat aatattttat aaactctttg ttagtttcta aaagctcctt
     1681 cgttactttt tgtctaccga accattttcc actctttgta tttatctcgc cagtattttt
     1741 cttatcctct tttagttggt ctattttctg ctgtgttctc tcttgaattg tttctctctc
     1801 catttctgca actgccccaa atataccaag taacatcttg tatgtattat tatttgtgtc
     1861 tataccttct tttaatattt ttactcttac acctttttga actaatgtat ctataatatc
     1921 aattaaatct tttaaattcc ttcctaaacg gcttatagac tcacagtaaa cagtatcccc
     1981 cttatttact tctactaaca ttctgcttaa tgcttctctt tcctttgttg ctcctgttat
     2041 tacatcttta tatattttat cgaacttaat tccctcattc tctaaaactc tctcttgtct
     2101 gctgttatct tgttttcttg tacttaccct ttcatatcct attatcataa ccctaccccc
     2161 atttgtcttg ttataataat tatacaatat attttttgtt cggtcaaact atatttttca
     2221 tttttgcaat gccgaacata ttttattgtt gatttccaat gattctatgt aaaaatcata
     2281 caaatattgt gtgtacggtc aaacgttggt ttttccgaac acgaacatat cacctttttt
     2341 atatcaacta ttccttaaat attttatata aaatcgccaa aatcttttta tattttttag
     2401 gcaaccaagt ttttaaaaca aaaatggtat atcagtaaga attatgtttt cacacaatat
     2461 aattcttaat gatataccat ttaagaacct cataagaggt agatagagat aattacataa
     2521 tcatcacata cgttttatca aatctgtttt gtaatagggt ttatacttaa ataataacaa
     2581 aaataccgta ttttttctac atttatactt tttttgttga tagtaaaata tggaaattag
     2641 tcatattttc agttattaac tcataagttt atacaacttt tatttaaata taataaaaac
     2701 atcaataata attaaattat tgaagcatat atttatatta atatctatca tttaaatttg
     2761 attgaaacag ttttatatct ctaatggatt ttttagaagc ttttacaata tcagttataa
     2821 atcttatttc atactcatta caatccctca aaacttcttc taactcattt tcaaagacag
     2881 ctttagaact taagattgta tcacataata attcatcaac cgacacccca agagtatttg
     2941 caatagcaac gagcgttggc aaacttacac ttgaatttcc cgtttcaata ttgctgacat
     3001 gttgtggact aacattgatt ttttctgata aaacttcttg tgttagcttt ttcttgattc
     3061 ttgcaatttt tatcctttga cctataaatt tgaaatcaag ctccatatgc gtattccctt
     3121 cctacaagta ttcacacata ttgtaacctt tcccaaagta tattataata aattaataga
     3181 atgtttcatt atgatagtta tagtgtatag aaaggaatta tatggatata ccaaagatac
     3241 ctcaaacaga actcaaagtc atgaaattta tttggagcaa aaacgacatt gtaacatcta
     3301 aagaagttgc aaaagctatg gaacttgaat atagttggaa aatgacaaca accctaacaa
     3361 tcttatcaag gcttgttatt aaacactttt tagcatctga acgaataggc agaatgacac
     3421 attatacgat actcatagca aaaaaagatt ataaaatatc tgaaacaaaa agatttctaa
     3481 atgacataca ttcaaattca ttggaaagcc ttttaaactc tttgaaagat tgcaatatta
     3541 cacataaaaa atagtacatg agtataaatt atattattat acctatgtac tatttaagtt
     3601 tttctataat gttcctatat ctatctaatt ttgattgatt tagatacttc tgtagtagtt
     3661 ttcaaaacgt ttcttaactc ttgtaagtgt attttctttt tttaatattt ttgagatgta
     3721 cttattaatg tttttgactc attttcagca gtaattattg caacagctct ataagtatgt
     3781 ccttttgtca cagaatatga gtttaaaaca gaacaagttt ttcctccagt tttctttgta
     3841 gatgttttta aatttaccca acttccgcct tttaattctt gtaacttagt tacaatagat
     3901 gttctagtta ctccagattt tccaacaaca gaagcattta catttgcttt tccattagaa
     3961 aatgataaat tacatctacc atttaatatg taaactgaaa aaggatttat ttcttcttta
     4021 ccatcttcca taaaaataat atcagatgaa ttaaactgtt cagcaaaact aacaacattt
     4081 actgacatta ttattatcaa cgcacataca aatattgaga ttatattttt tactctcatt
     4141 aagtacctcc ttataaaatc ttatatattc aatataacaa ctaactagca ctattttaga
     4201 caaaaattta cttaatattt tttgcaattt taataaattc ttttttatct ttcttagtta
     4261 ttttttttgt aggtagctct ttagataaca tataaatatt atttttatca tgccacaata
     4321 attgttgagt atttcctttt tcaacatact gtgcatactg attattaaat tttatattct
     4381 caacaaaagc atcctctgta tccaagacta taacatccct agaatataac atcatttgat
     4441 aaattatata gttatctaat ttatctttat ataatattga tagataattt tcttcctcaa
     4501 ttctctcaac ttctttatat ccagtagaaa tgtatttagg ttctatatat ttaaatgata
     4561 catttgattt atgagggttt ataaaattat agtctgtaaa ttctttatat accttcttca
     4621 ttattctaat taaattttct ggaaaagctt ctgtttttat agtagttata gtgactatac
     4681 ttgataaaat tattataaaa acaatagcaa ttttttttaa gtttttatag gtgttctttt
     4741 ttactttttt ctcattttct tttataattt tatccatttt actttcaaat tctatagaaa
     4801 attcatagtc aatatcttca tcacaaggta attcatacag tattttttct tctatttttg
     4861 gaagctgttc gtataataat ttttctatgt ctaatttatc tttattcatt tgataatgcc
     4921 tccatttcgc ttaaaatttt ttttaatttt tctaatgctc ttttatttct cttatacaaa
     4981 ttaacctctt ttatattcag tagtttagaa atttctctga tagaaaaacc atgactatat
     5041 tttaagagaa tcacctgtaa atctgtctct gacagttttt ttaaagcttc tcctaaataa
     5101 ctacactcac ctaacttttc aatcgataaa tctaaagagc tgaatttata gttatcatca
     5161 ttaatattac ttatttcctc tttttttctt ctattatata tatttattga aatccttttt
     5221 actataataa caacaaaacc tttagttttt ggactattca catcatttac tttatcaaga
     5281 ttatcaatta tttttaaaaa tgaactatga acagcatcct ccgctaaaac atcatctttt
     5341 aaaatttgat tagctacata aaacattaat ttcttatatt taatatatat ttcttcaaat
     5401 ttaattcttt cttcttttga atctataata gctaaatata ttaacataaa ttattctccc
     5461 ttaaaaaata ttatccttaa aaaaattata tacaatttat aaaaaattat atataaatgt
     5521 ctaaaaataa aaacttcatt tgttatatat ataaataaaa acataaaagg atggtgtttt
     5581 atatgaaatc aaaaagaata aacaaaatgt tagcaactac aatgacaatg gcaatgctag
     5641 caataccagc agtaacagca acatcatatg caatggaatc aacagggtta ggaacagaat
     5701 atacatataa taatgaatct aaacagcaag aagagtgggt taaatcattc gatactgaaa
     5761 caggaaaaga aatattatta aataaaacta ctaacgaaaa agtttctgaa gtatatgaaa
     5821 atgtaaatgg aaaattggtt aaattaagta ttaatgaagc actagaaaaa tttaatttaa
     5881 atgaggaaat tatcacaaaa tctcctaagt ctatttttgg agtatcaagt gttaaaaaaa
     5941 ttactggttc tgcacgcaaa atatcacaag acgtatcagg tggaaaacaa ggtgctacta
     6001 tatctatagg aaattcaaca actgtaactg aaagttttac tgttggtgga actacagaag
     6061 caataaaggc agcagtaaga gcaaatgcag gatttacatg gagcaaatct ttaacaagaa
     6121 gtgtcacaac tacacacaaa gtacctgcag gtaaaatagg atatgtagca tttaaaccat
     6181 attataaaga agtaagaggt acagtaaatg ggatacttgc aggaacttct ataactcaaa
     6241 aaatagtagc aaaaagtcct cttaaagcag gaaaagtttg tgatgggtta gaatatcttg
     6301 catacaaata ataaataata gaaagagttg attaaaatgg aaaataaaaa tatgtactta
     6361 agggttagtt taatattagc agtattaggc tttataatat tattttttaa taatgactta
     6421 gcattatcac taaaagcaac atacttagct gataaaggct tcgaagacat agttgaaaat
     6481 caaatattaa aaaactattc ctatatgttt ttaataatag gtggtgtact attttccata
     6541 ggaatctata acttaaccaa actgaaacaa attaataaaa aataaataaa ataagaggac
     6601 ttataaatta taagtccttt tattttacac ttataagcta ctttcaacct ttcatgattt
     6661 aacctttatt tatacaacac ccaaaactcg acctcaaaaa gagaacagga cttcgtcccc
     6721 cttaatacaa agcaacattt tttagtacta ttcgtactta agattagcta ttagattaat
     6781 ccttccaaaa gaacctcttt ttccgtttca tcaatcgcat ttaaaagttt atttattcta
     6841 gcttcaacta aatgctctat gcttaaatca ttgtctatta gtcctaattc tttttttatg
     6901 tcctctatgt ctatatgttt cttaatagtg taaactctaa ttactttttt atctgtcaca
     6961 gggtttggaa gtatattttt atagtattta tagggcaacc ctgtgacacc cctgtgttgt
     7021 ttgacttcaa taacaaaaat tgattgtaat attagactta ttttcttaat agttagcttt
     7081 ttcttagttg ctaaaaacgt ctgtaaatca acggctagag cttctaagtg ttcttttgta
     7141 taacttgtac caactccaaa attgaagttt atataattgt aagtataagt accaatatta
     7201 tcatcattta gcaaagaatt tgcgtatttt ttattaattt ttcgataaat tgttgtattt
     7261 atctgttcaa aaaatagatt tcttttctcg tctgacattg tcgcaagttt ccaagatagg
     7321 tcaatactat aactattatc taatacaaaa tcactaaata agtctatcgt ttttctacaa
     7381 ttattattaa ttattaggct atataaatca tgttccatat aatattttaa acagatatta
     7441 ttatctatcc tcatgtcatg atgatatttt aataagttac tgctggtcat tgacttctta
     7501 atttcactat agccaactag atacttttta tgtccttcta gttgttctat agctgatttc
     7561 ttaaattcct taatagcttc ctcatgctct tttatttctt cctctatttt tttagtttct
     7621 ttttcagttt ctactatctc aattttatta aaatattcct ctaatagcac tttgaagctg
     7681 tttattgttc ttgtttggta atagttattg taagcattac tttttatgta taacttgtcc
     7741 gttttatagc acatatcttt tttatcatag tatatattac tatcaatgtt ttttatgttt
     7801 atagggctta tatcaattcc tatagctcta tatggtaagt ctctcttaga agctttattg
     7861 tatatatttg ttaggctctc aacgtctttt atgttctcat ttatgcacca ttcaaccgaa
     7921 tatacattgc tatcctcatt tgtcgttttg taactattaa aaatatgtac atttatactt
     7981 tttgcccctc tagctcttgc aacatactgt tttatttttc ctacatcctt ttctccaatt
     8041 acaataatat ctgttacatt aggattattt atgtttacac ctgccgtgat tacagacgta
     8101 tttaaaagca cctcatagcc ttccatatcg gagtaactaa caattctatc atatagtttg
     8161 ctagtgtctt tagtatctga aataacaact ccactctttt tattaacttt ctttgatata
     8221 tagttaagtg ttgatatact atcttttaaa agcattgaat tatttgaatt atttagtatc
     8281 tctattactt tcccaatatt gattttatcg tataacttaa ctttgtattc cgtttgtata
     8341 ttttgtttat attcaataac tttgttatat atctcaaatt ctaatttaga gggtgttgca
     8401 gttatatcta gtctacctct gcacttatta gttatattat ttaagctctt tattgctttg
     8461 cttctgaacg catctgtgta agtctgatgt atttcatcaa taactattat gtactcgctc
     8521 aaatcctctt ttagaagctg ttcagtctta tcccacgtca tagccactaa cttgtttccc
     8581 tctaaagcgt gtttagtagg tatcttatca tatgcaccag ctattttata ttcgactatt
     8641 gcttgttgca cattcgcaga gttggggaat ataaagagtg cttttatatc cagctctttt
     8701 aatgtattta taattgagta tgtttttcca cttcctgtag gagctaccat taatacgttc
     8761 ttaccttctg tagcatgttt aattgactct ctaatacctt ttagattttc acttatgtat
     8821 ttatctatat taattatcga atcagcttta taacttgaat agttttgttt ttctagcatg
     8881 gattttattt taatattgtt atctaagtaa tactttcttt tgtccttatc agtcatacac
     8941 tcaaattcaa aagctaactc aatatcattg tttttaaaag cttcttgttt cttttcttct
     9001 atgaagctat ttatatcttt tttctttatg taaatgtttt taatagtatt atttgttttt
     9061 ttaatatttg tcttactctt gttaattggt aatgagatat tatatttatt ggctaggaat
     9121 aaaatagctt ctataggtct ttcaaagcgt tcatatgtgc gacataattc aattatatca
     9181 gcaccaacaa cacaattatg gctatagcat gtatatattc ttttgtttaa atcgaattgg
     9241 aagtttttat ccttaccacc atgaattggg caaggaacat tccttttttg agttgtatcg
     9301 actcctatat ctcttaaata tagttcatct atattggcat tttttattat atcaattaat
     9361 tgttttatat ctattttcat ttgtaaaaat cccccttttt tagttagggg ctaatcaagt
     9421 tttatcaagc tatgtattta cattctgccg taaatctcgt ataattaaca tataaaagaa
     9481 taaggaaata tatattttat atgttaatta agcctaagtg attagctcct agtattaacc
     9541 cctagtggct aactcctaat cttgattaac ccttaaatgg aaagaatgag tggatgccgt
     9601 caaacaaata ctcgttcttt ttcgtttttt ttgttattag tattatatca ctattaaagt
     9661 tataattcat tgtttagaat tatttttctg acggttttaa tatatatttt taatttcttt
     9721 tcaagcataa ttttttattt aagtctataa attcagctag gtcaagccca tctaaaaccc
     9781 ccattcggta tgcgtattct ttttcaatta cactgttacc aaatactttt tcctcaaaat
     9841 caattagcat ttttttatgt tctttttctt ccaatatttc taacaatctg ttcattattc
     9901 tttcagattc ttttttgtca tttaaatata tttcgttatt ttctagtagt ttatcttcta
     9961 aatttactcc gtatgtgtca aatccaattc ttaataaatc atcttttaac attactttta
    10021 acactccttt ttatgcacac ttaaatcttt tgcaccccta aatatggtaa tatattctat
    10081 ttattattat gtaattattt actatgtatt gtcaagcata tatattgttt ttggtacata
    10141 tttccgatac tatataataa aaaaggtggc gattaaattg ttggatatac aaataaataa
    10201 attattggaa aatcaaaata aaacacgtta ttggttagca aagcaaattg gaatgactca
    10261 tcaaaactta actaaactag ccaacaataa tacaaattct attaaatttg attctttaga
    10321 aaaaatttgt atggctctaa aatgttctcc taacgagctg ttcggttggg agcaagacaa
    10381 ataaaaaaat ataaatccta aagggtttat ttataactac tagaaaacta ctttagtagt
    10441 tattttattt tggaggttta aacatggata gatatacatt tgataactta cctatcaagg
    10501 agcaaataca atatattaat aacaagctct tagagggcaa tacattaact aacacatgta
    10561 aagatattgg tattggtcgt acaactataa gaaatagatt taaacaacat ggatatgaat
    10621 ttaatccaac taagaagcta tatatatcta ttattgaggt tgtcgaatta gaaagtagtt
    10681 caaaagtagt tgcgggcgac actagcaatg acaatacttt agttgatgca accaatattg
    10741 attttaataa cattttatct aaattcaatg atatgaataa taaactaaat gaagtatata
    10801 gttggtacga atcacaaagt agtaataaag tagttggggc tgataaacta aatatagacg
    10861 attttaaagg caatatagtt gttagaagct ataaggtcta tgaggatatt caaaaagagt
    10921 ttgtagcctt ctgtgaagct aataagaagt acagggtaca agatattatc agccaagctc
    10981 ttagggattt tatggataaa tataagtagt tttacttact ttctgatatt ctaaaaactt
    11041 ttcaatgaaa atctcatttt ttggcttcct gtgaaaaata tgtactcctt ccagtcctct
    11101 atctttattt actttattaa tccgataggg ggcgtattat atatatttct atcgagcata
    11161 tactcatcaa aacatagcat tagtttgatt attatatttc tatttatttt aagattatat
    11221 atacaatttg ccccttaata cattgcaatt actaacttct ttagttttga tattaatatt
    11281 taaatcattc ctttttaaag gtgctataag tgctatatag gcattgcaac ctatatactt
    11341 tttaggggtg cagttgcata tgcaagctct ttatttccca acacttaacc agttataaat
    11401 atttatatcc tttattagcc aaatatagca ttttaaacaa ctccgactat ctttagtagt
    11461 aacattttac atagctttat taatgtattt ttgcatctgc aaccatgttt ttaagttgca
    11521 acaccccacc cccacacctt acacaaaaca atacttatct ccgaagccat atacctacct
    11581 cggttcacat atttttcttc aacagcgtta ttttcagcaa ggggggctaa acattatact
    11641 ttttttcagt gcattaaata gccttacatg tattggtata actttatttc aaacccttaa
    11701 ttgaattgtt tcaatctaaa ttaagtaaat tttaataaga taaaatatat agtttgtaac
    11761 tttatttcaa aatacag
//
LOCUS       DAEHWM010000106        11738 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.109, whole genome shotgun sequence.
ACCESSION   DAEHWM010000106 DAEHWM010000000
VERSION     DAEHWM010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11738)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11738)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11738
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.109"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            90..653
                     /locus_tag="KNP36_003169"
     CDS             90..653
                     /locus_tag="KNP36_003169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875019.1"
                     /translation="MNKVYIVTTYTGTILSYLIRNISKKLYTHVSISLNENLKPMYSF
                     GRLNPRNPFIGGFVEENINQGLYAIRKNTVCRVYSLEVDNLQYENLYKNIKLISDYRE
                     DYYYDTMALIYLLMNIQRQSEYKYVCSNFVADMLEKSEIDILNKQAFEVTPNDFYNLS
                     GLTLEYEGLLSEYNSRQHSYVSKIANI"
     gene            1050..2750
                     /locus_tag="KNP36_003170"
     CDS             1050..2750
                     /locus_tag="KNP36_003170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424292.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875020.1"
                     /translation="MKRYLKTYGVALIIVIIYAFIKLPVLRLDFTSLFSVGIIFFVVA
                     GILDMMLDRNERASKMAKYNFSIAIALLVYIVVVPFITSTPVLHAKSYRELLGKVTES
                     KFTDDISPVSVNDIRLVDEDMAMKLGDKKLGEVPAIGSVSKLGKFHIQNVDGELYWVA
                     PLVHRDIIKWITSLSGTSGYVKVSASNPQDVQLVQEIDGKPIKIVYQPEAYLHQDLQR
                     HLYIHGIVNVGMTDFTLEINDEGRPYWVVSLYEHKIGYGGANATGIATVDAETGKINV
                     YDVKNTPKWVDRIQPQSFVTDQIKDWGVYVNGFLNSVISEKGVLVPTEGTSLVYGNDN
                     RSYWYTGITSSGGDESTIGFMLVDSRTKEARLYKQPGATETAAMKSAEGNVQEKNYEA
                     TFPVMYNILGQPTYVSSLKDKAGLVKRVAFVSVEDYNVLGIGEDKNEALRNYKDALES
                     KGNDLKLDNDLKDEVLEGTVTRISPDVRGGNTNYYVTLDSNKDIIFRATSKVSSELPL
                     TQVGDKVKISYSKEESGVIEMSEFDNLNIANFEDKKAKEKTGTDENTDSKDSENQGNV
                     "
     gene            2920..3537
                     /locus_tag="KNP36_003171"
     CDS             2920..3537
                     /locus_tag="KNP36_003171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875021.1"
                     /translation="MTNMEKEILLLISRVRCVTESQFRKIYGDQKRYNKKNFKKTLRK
                     MCSEYTLKKYPCDVDYYNYKDLSYVYYLNGSKLFKGDDLIKALVGSELVVRINTAGCD
                     VKRFYRNVSVDDVKYDLFIEYTDQFGNIKQVLVDVDLNNEIDISKYENLSKKIDKSTI
                     PFFKVPNVLVVTPDNLSELNDLERYDNEYSINFIDLGLNKLFNCI"
     gene            3898..5091
                     /locus_tag="KNP36_003172"
     CDS             3898..5091
                     /locus_tag="KNP36_003172"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HBF0875022.1"
                     /translation="MSIIVQKYGGSSVADTEKIKSIAENIIERRKENPQMVIVVSAMG
                     KSTDEYITLAKELSNEPSKRELDALMSTGEMISASLLSIALNALGCKAISYNAYQLNI
                     KTSGLHGKSQIDDINVNRIKNSLDEGNVVIVTGFQGINEDGDVTTLGRGGSDTSAVAL
                     AVKLNGKCEIYTDVDGIYFTDPRKYSKASKLDEIEYEEMLELASLGAQVMHSRSIELA
                     QKYGVEIYVGRTCGTEKGTYIRGGKDMKLEDKVITGLATSDDDSSITIKDFKAENISS
                     LFEDIATIGISVDMISQTAPILDKISVSFTVPKEELGECKKIVSKYTDEEHLVIDNNI
                     TKFSLVGLGMKNTSGVAAKVFKIFNENGIMIKLITTSEIRITCAINSDDKQVAIEKIA
                     EVFNI"
     gene            5109..6401
                     /gene="lysA"
                     /locus_tag="KNP36_003173"
     CDS             5109..6401
                     /gene="lysA"
                     /locus_tag="KNP36_003173"
                     /EC_number="4.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HBF0875023.1"
                     /translation="MKLHGTMTVNNDELYIGGVSCLELSKKYQTPLYVFDEALVRQNC
                     REYIEYFKAREGKNKVAYAGKAFLPLYMCNLINEEQMCLDVVSGGELYTAYKSNFPME
                     KVFFHGNNKTKEEINMGLDLGVGKFVVDNFYELDLLEALCEDKGKTQEIYFRITPGIE
                     AHTHDYIKTGQIDSKFGFALVNGDLFRAIEKLSEYKNIKLVGLHAHIGSQIFDVEPYI
                     DTVDIMMNLVKEIKEKFNIQLTEIDLGGGVGVYYSEGDKPKTIKEFCETIITKAETSC
                     KELGIEVPTLVIEPGRSIVANAGSTLYTVGSIKDIKDVRVYVSVDGGMTDNVRPSLYQ
                     ASYECSIVNKINHEAMNHVTIAGKCCESGDILIGDINIMDIKSGDILITTSTGAYGYS
                     MSSNYNKIPRAAVVSVFDGNDKIICKRQSYEDLLALEI"
     gene            6618..7277
                     /locus_tag="KNP36_003174"
     CDS             6618..7277
                     /locus_tag="KNP36_003174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein"
                     /protein_id="HBF0875024.1"
                     /translation="MRGRVILLISILSIFLVGCSFNKKDEINLVEQGKTYLEKHNYKK
                     AMESLSSALEEDSTNENARAMYMQAMRMSNMTEFEELKNYEGAIKELKLIEKIKNGSS
                     VIKEEATKKKEELTKLEKEQNEAEEQRKKKAKDTAGEDRYRVESDARKSSYSGSSKNN
                     KSSSKNNDKKSDSNKSDNNNSSSQNQEKPNNSNPTPAPTPQDTTGGSDSGGNSQNSNN
                     Q"
     gene            complement(7432..8517)
                     /locus_tag="KNP36_003175"
     CDS             complement(7432..8517)
                     /locus_tag="KNP36_003175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBF0875025.1"
                     /translation="MIIISKENIKYYLIVVFIGILFFKFINTPSDFISSIEGFLKFFS
                     PFLLAILLALLLNPLVMLFEIKFKAHRLLAIFLSYIFIGFILAFAIRLLIPSIANTLN
                     RLINEMPMYTDYIDSFIEKNMSNIYFLKTLIPHIQHSLDNLLKEASNFVGKIPKNFLI
                     YTLSISSMLFNMTMGFILSIYIIYDKEKIALGFKRFLYSSTARNKADNIIEFFRTTHD
                     IFYDYLLGRILDSLIIGIIAFLGFQFVIRIENALFLASIIFLGNIIPYFGPFIGAIPP
                     IAMTILYSPQKTIWVIAFLFILQQLDGNFIEPKVMGNQVGIGAIWVISAILVGQSLFG
                     FIGVFLSVPIAAVVKTYVDKYIDNRLQ"
     gene            8708..9424
                     /locus_tag="KNP36_003176"
     CDS             8708..9424
                     /locus_tag="KNP36_003176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HBF0875026.1"
                     /translation="MRINKYIASCGIASRRKAEEIILGGRIKVNGSVVKELSFNIDEE
                     KDIVEFDNKKVKPSENYIYIVLNKPEGYITTVKDQFNRPSVIDILKDVRERVYPIGRL
                     DYETSGLLILTNDGDLTYKLTHPKHEIDKMYVASVKGIISDDEIRQFETGLKIEDYTT
                     APAKIRVTKENKEKNYSVCEITIHEGRNRQVRKMCKAINHPVLNLRRISVGKIVLKDT
                     KVGEYRYLTEDEIKYLKSIK"
     gene            9482..10060
                     /locus_tag="KNP36_003177"
     CDS             9482..10060
                     /locus_tag="KNP36_003177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBF0875027.1"
                     /translation="MAYAKYLTKITDINKFYLENIINEGDIVIDATMGNGYDTRYLAE
                     KVGEKGFVYAFDIQEEAIKSTRKKLEKEGYTDRVKLIFDGHEKMNQYIKEEVSCVLFN
                     LGYLPRAKHSIITKPDTTLKAIKLSLEMLKENGVISIAIYTGHDGGQEEKDCIYNLVN
                     NLNQDEFNVLESKFLNQVNNPPQLILIEKKKA"
     gene            10454..11326
                     /locus_tag="KNP36_003178"
     CDS             10454..11326
                     /locus_tag="KNP36_003178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0875028.1"
                     /translation="MEETNEMKDSKHLISNIQSQYTRLSKGQKLIAQYILNNYDKVAF
                     MTACKLGETVGVSESTVVRFANALGYSGYPKLQAALQELIKNKLTTVQRVEMAHDYSD
                     DFAILNKVLKSDIDNIRSTLEEIDERAFKEASNKLLRARKIYILGMRSSFVVAQYLGF
                     YLDIILDNVHIIRMDMGDAFEQIVRINEEDVIVAISFPRYSKKSYQIVNYAKEKGAHV
                     ISLTDSLFAPVASLADNTLLVKSNMASFVDSLVPALSISNALAISVGMKEKEDIKQHF
                     DDLEQIWKRYSVYE"
BASE COUNT         4836 a         1215 c         2001 g         3686 t
ORIGIN      
        1 tgtaaaacca catttattat gttagaatat cttatgatat taaattgtaa gtgtataata
       61 ttatttagtt actagattgg ggggaaatga tgaataaagt ctatattgta acaacatata
      121 caggaactat attatcttac ttaataagga atataagtaa aaagctgtat acacatgtgt
      181 caatatcatt aaatgaaaat ctaaaaccaa tgtattcttt tggaaggcta aatccaagga
      241 atccatttat tggaggattt gttgaagaaa atataaatca aggattatat gctataagaa
      301 aaaacactgt gtgtagggta tattcgttag aagtagataa tttacaatat gaaaatctat
      361 ataaaaatat aaaattaatt agtgattata gagaagatta ctattacgat acaatggcat
      421 taatatattt actaatgaat attcagagac aatctgaata taaatatgta tgttcaaatt
      481 ttgttgctga catgttagaa aaaagtgaga tagacatttt aaataaacaa gcatttgaag
      541 taacgccaaa tgatttttat aatttatctg gcttaacctt agagtatgaa ggtttattat
      601 cagaatataa ttctagacaa cattcttatg tatcaaaaat cgcaaacatt taaaaacttg
      661 atttagagtt tttcatataa aaaaatattg ctagataatt aggctgaaga tagtagttta
      721 acttcgatag gattaagaat ttgtaaatct tagttagaat actttcttca gtttttaaat
      781 ttctgctaat atttgtattt ttataacatt tttggatata tataatacag aatagtgcaa
      841 aaatcccact cctttaggtg cgggatggat agcacaaaca gtgtataaaa agtatttata
      901 catacacgta taatgttaaa tatagttgaa taagcagaac tataaatata taaagatatc
      961 ttaatatata ataaatatga taaatattta ttttttgtaa atatatggat ataatagtaa
     1021 taataacatt ttttagagag gagtattaaa tgaaacgata tcttaaaaca tatggagttg
     1081 cattaataat tgtaataatt tatgcattta ttaaattacc tgtactaaga ttagatttta
     1141 catctttatt ttcagtagga ataattttct ttgttgtagc aggaatacta gatatgatgt
     1201 tagatagaaa tgaaagagca tctaaaatgg ctaaatataa tttttcaata gcaatagctt
     1261 tgcttgtgta tattgtagta gttcccttta taacttctac acctgtactt catgcaaaat
     1321 catatagaga actattggga aaagtaactg aaagtaaatt tactgatgac attagccctg
     1381 tcagtgtaaa tgacattcgt cttgtagatg aagatatggc aatgaaatta ggtgacaaaa
     1441 agcttggaga agttcctgca atagggagtg tatccaaatt aggaaaattt catatacaaa
     1501 atgtagatgg agagttgtac tgggtagcgc ctcttgttca cagagacata attaaatgga
     1561 taacatctct aagtggtaca agtggttatg taaaagtatc agctagtaat cctcaagacg
     1621 tccaattagt tcaagaaata gatggaaagc caataaagat agtttaccaa ccagaagcct
     1681 acttacatca ggatttacaa agacatttat acatacatgg tattgtaaat gttggtatga
     1741 cagatttcac tcttgaaata aatgatgaag gaagacctta ttgggttgta agtttatatg
     1801 aacataaaat tggctatgga ggagcaaatg caacaggaat agccactgtt gatgcagaaa
     1861 ctggaaaaat aaatgtttat gatgttaaaa acacgcctaa atgggtggat agaatacaac
     1921 cacaaagctt tgtaacagac caaattaaag actggggtgt ttatgttaat ggatttttaa
     1981 actctgttat atcagaaaag ggagttttag taccaacaga aggtacatca ttagtttatg
     2041 gcaatgataa caggtcttat tggtatacag gtataacatc ttcaggtgga gatgaatcta
     2101 caattggatt tatgttagtt gattctagaa caaaagaagc tagattatat aaacaaccag
     2161 gagctactga aacggctgca atgaaatcag ctgaaggtaa tgttcaagaa aaaaattatg
     2221 aagcgacgtt ccctgtaatg tataatatat tgggtcagcc aacatatgta tcatcattaa
     2281 aagataaggc gggtcttgtt aagagagttg catttgtatc tgttgaagat tataatgtac
     2341 ttggaatagg tgaagataag aatgaagcat taagaaacta taaggatgca ttagaatcta
     2401 agggtaatga tttaaaactt gataatgatt taaaagatga ggtattagaa ggcacagtga
     2461 caagaataag cccagatgtg cgaggtggta acactaatta ttatgtaact ttagattcaa
     2521 ataaagatat aatatttagg gctacttcaa aagtatctag cgaattgcca ttgactcagg
     2581 ttggtgataa agtcaaaata tcgtattcaa aagaagaatc tggtgtaata gaaatgtcag
     2641 aatttgataa cctaaatatt gcaaactttg aagataaaaa agcaaaagaa aaaacaggaa
     2701 ctgatgaaaa tacagattcc aaagattctg aaaatcaagg taatgtataa tttaaataaa
     2761 aagattgata atagtattta acatagtgat agctaatttt tatagaattt aattctataa
     2821 aaattagcta ttttatttta attctttgta aatttaatgt cataaaatta atataatatt
     2881 agtacaactt tgcaaataat acttcaagga gaatgtacta tgacgaatat ggaaaaagag
     2941 atattacttt taattagcag ggttagatgt gttacagagt ctcaatttag aaaaatttat
     3001 ggagaccaaa aaagatacaa taaaaaaaat tttaaaaaaa ctttgagaaa aatgtgtagt
     3061 gaatatacac taaaaaaata tccttgtgat gtggattatt ataattataa agacctctct
     3121 tatgtatact atttaaacgg tagtaaactt tttaagggag atgatttaat aaaggctcta
     3181 gtaggatcag aattagttgt tagaatcaat actgcaggtt gtgatgtaaa aagattttac
     3241 cgaaatgtta gtgtagatga tgtgaaatac gatttattta ttgaatatac agaccaattt
     3301 ggtaatataa agcaagtttt agttgatgtt gacttaaata atgaaataga catttctaaa
     3361 tacgaaaatc tttctaaaaa aatagataaa tctacaattc cattttttaa agtaccaaac
     3421 gttttggtag ttacaccaga taatctatcc gaattaaatg atttagagag atatgataat
     3481 gagtatagca taaattttat agatttagga ttaaataaac tatttaattg tatataagct
     3541 aactttagaa aagaaaacta tcgatttgcc acattttgta aaataattgt tgcaatatta
     3601 tatagaatat gataaaacta tattaataaa ttaattaaaa ataatgagcc tagggtagag
     3661 gtagctgtat tcaatagtat tcaataggag ctggtaagcg ttgataattg atgaaagggt
     3721 atatagccga agaaattttg ttgacggaca aattttctgg acttatgcag aatatgcata
     3781 aggctgtcac ttttaaagtg gtgagctaca aggttacttg gtctatgaaa tttacacgtc
     3841 caaagtatac ctttgggcgt ttttatttat caaaatttag cttgaggggg agaaagcatg
     3901 agtataattg ttcaaaaata tggtggaagt tcagtagcag atactgaaaa aataaaatca
     3961 atagcagaaa atataataga acgaagaaaa gaaaatccac aaatggtaat agttgtatct
     4021 gccatgggaa aatccactga tgaatatata actttagcaa aggaattgag taatgaacct
     4081 agtaagaggg aattagatgc tttaatgtct actggtgaaa tgatttcagc atctttatta
     4141 tcaatagcat taaatgcact tggatgtaaa gctataagtt ataatgctta ccagttaaat
     4201 ataaaaacga gtggtcttca tggaaagtct caaattgatg atataaacgt aaacagaatt
     4261 aaaaatagtt tagatgaagg aaatgtcgtg atagtaactg gatttcaggg aatcaacgaa
     4321 gatggtgatg taaccactct tggaagaggt ggttcagata catctgctgt agctcttgcg
     4381 gttaaattaa atggaaaatg tgagatatat acagatgttg atggaattta ttttacagac
     4441 ccaagaaaat attcaaaggc tagtaaactt gatgagattg aatatgaaga aatgcttgag
     4501 ttagcgagtt taggagcaca agtaatgcat tcaagaagta tagagcttgc acaaaaatat
     4561 ggtgttgaaa tctatgtcgg acgtacatgt ggtacagaaa aaggaacata tataagaggg
     4621 ggaaaagaca tgaaattaga ggataaagta ataacaggat tagctactag tgatgatgac
     4681 agttctataa caataaaaga ttttaaagct gaaaatatat ctagcttatt tgaagatata
     4741 gcaactatag gtataagtgt agatatgata agccaaactg cacctatttt agataagata
     4801 agtgtatcat ttacagttcc aaaagaagag ttgggagaat gtaaaaagat agtatctaaa
     4861 tatacagatg aagaacattt agtgattgat aataatatca ctaaattttc tttagtaggt
     4921 cttggtatga aaaatacttc tggagttgct gctaaagtat ttaagatatt caatgaaaat
     4981 ggtataatga taaaacttat aactacatca gagattcgta taacttgtgc tataaattct
     5041 gatgataagc aagtagctat agaaaaaata gcagaagtat ttaatatata aaatttgggg
     5101 aggctattat gaaacttcat ggaactatga ctgtaaataa tgatgaatta tatattggag
     5161 gagtgagttg tttagaactt agtaaaaaat atcaaactcc actttatgta tttgatgaag
     5221 ctttagttag acaaaattgt agagaatata tagaatattt taaggctaga gagggaaaaa
     5281 ataaggttgc ttatgcaggg aaagcttttt tacctcttta catgtgtaat cttataaatg
     5341 aagaacaaat gtgtttagat gtagtttcag gaggcgagtt atatacagct tataaatcaa
     5401 attttcctat ggaaaaagtt ttctttcatg gaaacaataa gactaaagaa gaaataaaca
     5461 tgggattaga tttaggtgta ggtaaatttg tagtggataa tttttatgaa ttagatttgc
     5521 ttgaagcatt atgtgaagat aaaggtaaaa ctcaagagat atactttaga ataactcctg
     5581 gtatagaagc tcatacacat gattatataa aaactggaca gatagattct aaatttggat
     5641 ttgctttagt aaatggagat ttatttagag caatagaaaa attaagtgaa tataaaaata
     5701 ttaaacttgt aggtcttcac gctcatatag gttcacaaat atttgatgta gaaccataca
     5761 tagatacagt ggatataatg atgaacttgg taaaagaaat aaaagaaaaa ttcaacatac
     5821 aactaacaga aattgaccta ggtggaggag ttggcgttta ttatagcgaa ggagataaac
     5881 ctaaaactat aaaagagttt tgtgaaacca taatcactaa agcagaaact tcatgtaaag
     5941 agcttggaat agaagtacct acattggtaa tagaaccagg aaggtcaata gttgcaaatg
     6001 caggaagtac attgtataca gtaggttcta taaaagatat aaaagatgtt agggtttatg
     6061 taagtgtaga tggaggtatg acagataatg taagaccttc gttgtaccaa gctagttatg
     6121 agtgtagtat tgtgaataaa attaatcatg aggctatgaa tcatgtaaca atagctggaa
     6181 aatgttgtga gagtggagat atattaattg gagatataaa cataatggat attaaaagtg
     6241 gagatatact tataacaaca tcaactggtg catatggata ttcaatgtct tcaaattata
     6301 ataaaatacc aagagcagca gtggtatcag tatttgatgg aaatgataag ataatttgta
     6361 agagacaaag ctatgaggac ttattagctt tagagatata aaatagagaa gtatataata
     6421 aaaattaaat attaaagttt attatgagca gatttgctag gatatgtatc tctaaattaa
     6481 tttttggttt attgtatcgt tcgtagcata tctgcttatt ttttgtttta ctaacaaatt
     6541 tcttgtaata aatataaaat attttaaaaa ctttataatt atgataaaat ttaaagtata
     6601 tgacaaggag ggatttaatg agaggaagag taattttatt aatatcgata ttatctatat
     6661 ttcttgtagg atgttcattt aataaaaaag atgaaataaa tttagtagag caaggaaaaa
     6721 catatttaga aaaacataac tataaaaaag ctatggaatc attatcctct gcactggaag
     6781 aagatagtac taatgagaat gcaagagcta tgtatatgca agctatgaga atgtcaaata
     6841 tgacggagtt tgaagaatta aaaaattatg agggtgcaat caaggaactt aaacttatag
     6901 agaaaatcaa aaatggttcc tctgttatta aagaagaggc aactaaaaag aaagaagagt
     6961 taactaaatt agaaaaagaa caaaacgaag cagaggaaca aagaaagaaa aaggcaaaag
     7021 atacggctgg agaagatagg tatagagttg aatcagatgc aaggaaatct tcttatagtg
     7081 gaagtagtaa aaataataaa tctagttcta aaaacaatga taaaaaatca gatagtaata
     7141 agtctgacaa taataacagt tcttctcaaa atcaagaaaa gccaaataat agtaatccaa
     7201 caccagcacc aactccacaa gatactactg gtggttcaga tagtggtgga aattctcaaa
     7261 actcaaataa tcaataagta taaaatatat gcataaattt aatgaacaaa ttatatatta
     7321 taaaaaatat ctcttagcaa ttttttctta ctaagagata ttttttgaga aataatttaa
     7381 taaatagcag ttaaatttta aactaaaaat taaagtcaca gtagagataa tctattgtaa
     7441 acgattatct atatatttat caacataagt ttttacaaca gcagctattg gtactgaaag
     7501 aaaaactcct atgaaaccaa atagagattg tcccaccaaa atagcagata ttacccatat
     7561 agctcctata ccaacttgat tacccataac ttttggttct ataaaatttc catctaattg
     7621 ttgcaatata aatagaaatg caatgaccca tatagttttt tgtggactat ataatatagt
     7681 catggctatt ggagggattg caccaataaa aggaccaaaa tagggaatta tattacctaa
     7741 gaatattatt gaagctaaaa ataaagcatt ttctattctg ataacaaatt gaaatcctaa
     7801 aaatgcaatt ataccaataa taagagagtc taatattcta ccaagtaaat aatcatagaa
     7861 aatatcatga gtagtcctaa aaaattctat aatgttatct gccttgtttc tagcagtaga
     7921 agaatataga aatctcttaa atcccaatgc aattttttct ttgtcatata taatgtatat
     7981 agatagtata aatcccattg tcatattaaa tagcatagaa gatatactaa gtgtatagat
     8041 taagaagttt ttaggaattt taccaacaaa attacttgct tcttttaata aattatctaa
     8101 actatgttgt atatgaggaa ttaaagtttt tagaaaatat atgtttgaca tatttttttc
     8161 tataaaacta tctatataat cagtatacat aggcatttca tttatcaatc tatttaatgt
     8221 attagctatt gatggaatta ataacctaat ggcaaaggct aaaataaaac ctataaatat
     8281 ataagataaa aaaatggcta aaagtctatg tgctttgaat tttatctcaa aaagcatcac
     8341 aagtggattt aaaagtaaag caagtaaaat agctaataaa aatgggctaa aaaactttaa
     8401 gaatccttca atactagata taaagtctga tggagtatta ataaatttaa aaaataaaat
     8461 tccaataaac acgactatta aataatattt tatattttcc tttgaaataa taatcacttc
     8521 cttaaaatag tgtttagtca gctattacat attaatagta tgtgaaaaga aattacaatt
     8581 atttaggaaa attaaataat ttttttgctt gtttttaatt aaggtctagt atagtataat
     8641 aatgtagcaa aattaacatt gataaaaata ttaaacacac ataatttaag ataaggaagg
     8701 attaagtatg agaattaata agtatatagc ttcttgtgga atagcatcaa gaagaaaagc
     8761 agaagaaata attcttggag gaagaataaa ggtaaatgga agtgtagtaa aagagttatc
     8821 ttttaatatt gatgaagaaa aagacatagt agaatttgat aataaaaaag taaaaccaag
     8881 tgaaaattat atatatatag tattaaataa accagaggga tatataacta cagtaaaaga
     8941 ccaattcaat agacccagtg taatagacat acttaaagat gtaagggaaa gagtatatcc
     9001 aatagggaga ttagattatg aaactagtgg tttattaata cttactaatg atggcgattt
     9061 aacatataag cttacccatc caaagcatga aattgataaa atgtatgtgg caagtgtgaa
     9121 gggaattata agtgatgatg agataagaca attcgaaaca ggactaaaaa tagaagatta
     9181 cacaacggca cctgccaaaa taagggtaac taaagaaaat aaagaaaaaa attattcagt
     9241 gtgtgaaata actatacatg agggtagaaa tagacaagta agaaaaatgt gcaaagctat
     9301 aaatcatcca gttttaaatt taagaaggat ttctgtgggg aaaatagtat taaaagacac
     9361 caaagttgga gaatatagat acctaacaga agatgaaata aaatatttaa aatcaataaa
     9421 ataagataaa aataaattga gaaaaaatga aataaagtta atagtaggga gaaatagtat
     9481 tatggcatat gcaaagtatt taactaaaat tacagatata aataaatttt atttagaaaa
     9541 tattataaat gaaggtgaca tagtaattga tgctactatg ggaaatgggt atgatacaag
     9601 gtatctagct gagaaggttg gagaaaaggg ctttgtatat gcttttgata tacaagaaga
     9661 agcaataaag tctacaagaa agaaactaga gaaagaagga tatacagata gagtaaaatt
     9721 gatatttgat gggcatgaaa aaatgaatca atatataaaa gaagaagttt catgtgtttt
     9781 atttaatttg ggttatcttc caagagcgaa acattcaatt ataaccaaac cagatacaac
     9841 tttaaaggct ataaagttaa gtttagaaat gttaaaagaa aatggagtaa taagcattgc
     9901 catatataca gggcatgatg gaggtcaaga agaaaaagat tgcatatata accttgtcaa
     9961 taatttaaat caagatgaat ttaatgtttt agaatctaag tttttaaatc aagtcaataa
    10021 cccaccacaa ttgattttaa ttgaaaagaa aaaagcataa taaatactaa aaaacttgac
    10081 aagattgtat taagagttaa tatatatagt gtgacctatt aaaaatactt taaataataa
    10141 gtatacaaca gtttattctc aaaacaaaat atacatctaa atatgcaaaa taagatagat
    10201 aacttttaaa tgagtaaaaa ttgaaaaatt taaaagaaat attggataaa tattaaaaaa
    10261 tgcaaggaaa gatggtataa taaatttaat cgaaaatact atgtgaagta taaggtacag
    10321 aaaagttaga attttatgag tttaagaagc tatgataaaa actaagatga aattgagata
    10381 aaaaataaaa tttttagaga aaaagacagt gttaataaaa caaaatagtt tatataacta
    10441 aaaggagaaa aaaatggaag aaacaaatga aatgaaggac agtaaacatt tgatatcaaa
    10501 tatacaatct caatatacga gattgagtaa gggtcaaaaa cttatagcac aatacatttt
    10561 aaataattat gataaagttg catttatgac tgcatgtaaa ttgggtgaaa ccgtaggagt
    10621 aagtgagtct acagttgtaa gatttgcaaa tgcattaggt tatagtggat atcctaaatt
    10681 acaagctgca cttcaagaac tcataaaaaa taaactaact acagtacaaa gagttgaaat
    10741 ggcacatgat tattccgatg attttgcaat actaaacaaa gttttaaaaa gtgatataga
    10801 taatataagg tctacactag aagaaattga cgagagagcg tttaaagaag cttctaacaa
    10861 acttttaaga gcgagaaaaa tatatatact tggaatgagg agttcttttg tagtagctca
    10921 atatttaggt ttttacttag atataatact tgacaatgtt catataatta gaatggatat
    10981 gggagatgct tttgagcaga ttgtaagaat aaatgaagaa gatgtaatag ttgctattag
    11041 tttccctcgt tattctaaga aatcttatca aattgtcaat tatgctaaag aaaaaggagc
    11101 ccatgtaata tcattaacag atagcttatt tgcgccagta gcatcacttg cagataacac
    11161 tcttctagtt aagagtaata tggcttcatt tgtagattct ctagttccag ctcttagtat
    11221 ttcaaatgcc cttgctatat ctgttgggat gaaggaaaaa gaagatatta aacagcattt
    11281 tgatgattta gagcaaattt ggaaaagata ttctgtgtat gagtaaagtt tgtatattaa
    11341 taaggctatg aaattgagaa tcatagcctt attagtaaat actcgattat cacttaaaaa
    11401 ataaattttc gtttaaataa tacaaataaa tatttcgaga ctcaaaacat aaagatgtat
    11461 tctgaataca tctttactac gtcaactaat ttattaaaga aagcatttcc attcatggag
    11521 agtgcttttt ttatttctct aaacaatatc atttccttaa ttaacaatta taaaattaat
    11581 tttatttgta tttaagtata taatatctta ttaaaattat attaaaatat gtatttctat
    11641 cttttttgtt cactataata tgtgtctttt agtattttat tttaactttg acaaagaagt
    11701 tgaaaaattt aaaaatcata gaattagtag ttaggtat
//
LOCUS       DAEHWM010000107        11222 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.110, whole genome shotgun sequence.
ACCESSION   DAEHWM010000107 DAEHWM010000000
VERSION     DAEHWM010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11222)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11222)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11222
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.110"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..179)
                     /locus_tag="KNP36_003179"
     CDS             complement(<1..179)
                     /locus_tag="KNP36_003179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875029.1"
                     /translation="MQTEWNFGYNGSPQSVILKPGKYKFECWGSSGGINNSSWHTDAK
                     GGYSKGEITLKKQTT"
     gene            complement(196..1188)
                     /locus_tag="KNP36_003180"
     CDS             complement(196..1188)
                     /locus_tag="KNP36_003180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015984856.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HBF0875030.1"
                     /translation="MAIDKSYYTIITDVGKAKIANASVTGNKVGFVKIQLGDGGGSEY
                     TPTESQTALKNVVWEGNIGNTTTDETAPNCIILESLIPSSVGGFMIREIGYLDDENNL
                     IAISKYKECYKPSIEQGAVVDMKVKTVLIVSNVNNIELKIDPTIIFATLKDIQDLETK
                     IGTVNTKIDTTKTELNTRIDTENEKQNIKIDQLIAGGSNVSHTHIIEIDDWILNNETN
                     MYEVTINHPLLTKRILIALYDEIGEALTPNARAIDDNSILVRNEENIKMYVYLINGNA
                     ETHFINATVDDNRVSEMTTYSSKKIEDRFLNLEEKVNGGLSSIATSVNELITYC"
     gene            complement(1200..1817)
                     /locus_tag="KNP36_003181"
     CDS             complement(1200..1817)
                     /locus_tag="KNP36_003181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YmfQ family protein"
                     /protein_id="HBF0875031.1"
                     /translation="MDKEINLINYLPQILRDKEEYIKVFNVENKEIKTLHEKLNDLSN
                     DQFLEDLTPSGIKRWEKIMSITPKSNESLEDRRFRIFSKYISKLPYSERFLRNWLDNV
                     VGEGNYELTINNATYNIHLESDARNQDWFEEVHSFVSNIKPCNMTLDYTRVLISKDNY
                     MNFGITTLMGQEITIYPWSPPDIETYGEIDVLTGNGVGYQEITIF"
     gene            complement(1810..2859)
                     /locus_tag="KNP36_003182"
     CDS             complement(1810..2859)
                     /locus_tag="KNP36_003182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="baseplate J/gp47 family protein"
                     /protein_id="HBF0875032.1"
                     /translation="MFELMTFENIIKRMLDSVPDTFDKREGSIIYNALAPVAIELTET
                     YIAMDELLDQTFVDTASYYYLEKRCKERGITPLPATNTIAKGVFNIDIPIDSRFNLGE
                     YNYVAIERISEKTYKMKCETTGPVFELGQLIPIEYVDKLETAELTEILINGEDEESED
                     SLRQRYYDSLNSQSFGGNMQNYKDEVNKIQDVGGVKVYPVWDGGGTVKLVIINSNFKV
                     PSSDLVNLVQEEIDPLQNQGEGLGLAPIGHRVTVEGVTSTTINISAEITYKNGYTWEN
                     IKSIAEEAIDDYLNELNMSWEDEENLIVRISQIETRLLSIDGVLDIANTMINSIASNL
                     NVDKDSIVLRGEVVG"
     gene            complement(2860..3279)
                     /locus_tag="KNP36_003183"
     CDS             complement(2860..3279)
                     /locus_tag="KNP36_003183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2634 domain-containing protein"
                     /protein_id="HBF0875033.1"
                     /translation="MLPTDNIDYDIEDVSIINFDVRQEPSKTFKLNIEKSKIDGICDD
                     VEALKQTIFLILNTERYQHLIYSWNYGVELNDLIGEPISFVIPELERRIKEALIQDDR
                     VENVDNFEFQNVKGKVHCKFTVYSKYGNIKAEKVVSV"
     gene            complement(3284..3544)
                     /locus_tag="KNP36_003184"
     CDS             complement(3284..3544)
                     /locus_tag="KNP36_003184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2577 domain-containing protein"
                     /protein_id="HBF0875034.1"
                     /translation="MSQDLLQIIKKAAMDAVETSNPMQIAFGTIESVNPLVVKIEQKA
                     SFEESFLIQTDTFKRYTDKKIGDKLVLIRMQGGQQYLILDRM"
     gene            complement(3558..5531)
                     /locus_tag="KNP36_003185"
     CDS             complement(3558..5531)
                     /locus_tag="KNP36_003185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /protein_id="HBF0875035.1"
                     /translation="MSDDLVLANDRDIRLVIAHWEDFYEPVVLDGITWEIERRGTPSK
                     LEFTIVMDDILQFCEGNSVRLYFKGIGIFYGYIFQKKRDKENHIKIVAYDQLRYFKNK
                     DTYVYNNQTASELVKMLAKDFNLKYNVIEDTKYKISRIEENKTLFDMILTALDDTLRE
                     KKEMYVLYDDFGRITLKNVASMKLDTVMNNDVIEDFDYNSSIDSDTYTKIKLVRDNEE
                     TGKRDVYIAQDSTHMRSWGILQMFDTVDKNMSEAEIKQKCDILLKLYNKKTKSLSLKN
                     VLGDIRVRAGCLVPVFLDLGDIDLQNYMLVEKVKHTFENNSHFMDLTLVDGDEFASYS
                     SSSYSSGNTNNKDEKKNGPAQSTTSKEDNDMINKLNKVFKNKLSNTGSIFVKYSNAYK
                     VNAALMAAISIHETGNGSSSLCKNKNNFFGMKGMSFGSVDEGIKRGISNLSRNYIHMG
                     RKTLESIRDKYAPLYDSPLNKHWVPGVNKFYKQITGNAYSSNSAGTGVRSNEEAEKNL
                     KDITYQVQNSNNANTSTNNNSKVNKVIQEAKNQLGKPYKWGGNGPKSFDCSGLMVWAF
                     KRGAGINLKRVSADQSNDSRGKLLCNINDVKAGDLVFFAYNQGKGNVHHVGLCIGNDK
                     FIHSPNTGDVVKISSLSGRQKQKHDFARARRFF"
     gene            complement(5524..6225)
                     /locus_tag="KNP36_003186"
     CDS             complement(5524..6225)
                     /locus_tag="KNP36_003186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HBF0875036.1"
                     /translation="MAYDFYLDGVQLPIPPPKLEIKVTNKNKTVDLINTGEVNILKKE
                     GLSEISFEAEFTHNKLPFYRGIFRDVQFFLSKLELLKTDCKPFQFIVSRELGNKVLFN
                     TNMKVSLEEYNIVEDAENASDTKVAIKLKQYRDYSTKKLVLATPEKTNYGRTPPPVMK
                     PKEFRPDSSNKPNGKTYTVKAGDSLWAICQKQLGNGSLYKKVYELNKTMMDKANKGKK
                     LSKYTIYKGQVLRLV"
     gene            complement(6237..8588)
                     /locus_tag="KNP36_003187"
     CDS             complement(6237..8588)
                     /locus_tag="KNP36_003187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tape measure protein"
                     /protein_id="HBF0875037.1"
                     /translation="MATIQTSIRIFDGMTPAFRSMTASINTTINSLERLQGRLNNPLN
                     TGGIQTSQQSLNNIENILTRIEQNIGKADEQQRKFNEDINKGASSTNNLLGSVKKIAG
                     AYMGLKTIGGLGSLSDQMTSTNARLAMINDGQLSDSGLNKMIFQSAERSRASYLDTAQ
                     IVSRIGMNAGSAFSSTREIVSFAEQLNKKFVIAGASTEEMNSALLQLTQGLGSGVLRG
                     EELNAVFESAPNIIRSIADYLDVDIGKIRGMASEGMLTADIVKNSLLAASAETNAQFE
                     KMPYTLGQIFTSIKNNAVMIFGAIQKKIEDTVSSRGFRTFITNVTDSLYVLGAVGYSV
                     FNGIIDLLSSPAFSGFFNMMIVGASLVAQGLGWIITQALSVANVFAQNWSIISPVIYG
                     IVGAFIAYKVIIYSVLIAQTIYTAITFTQCFVTALLSGELYVATKAMLINKLMTLGVS
                     RANVTLCATMIMVVAAVALVIAAIFVGVAIFNHFAGTSISATGVVVGAFYFLGTCIYD
                     VFAGAWNIVMAFAEFFVNSFNIVIYNVQMLFYKFQNFVINAMGDVGGSFDNCATALAN
                     AFVSAANIAIKGINGVIKALNLIPGINIKTIGSLDKVDSFVKQYKDYQKTLKEPVKPQ
                     DWKAPYMDIKNPFDSYKKGYEVGQNLENKLKDTFDINKIAEKAKKDLGLDDIWDKKYG
                     LGDSIGSAGLNSPLNDAAKGAKDTAGNTAKMAKTMDKSQEDLKYLRDIAEQETINRFT
                     GVNIKIDMNNTNNISKDADVDGIVNVLTEKLNDAMVVSAEGIV"
     gene            complement(8654..9436)
                     /locus_tag="KNP36_003188"
     CDS             complement(8654..9436)
                     /locus_tag="KNP36_003188"
                     /inference="COORDINATES: protein motif:HMM:NF021378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SHOCT domain-containing protein"
                     /protein_id="HBF0875038.1"
                     /translation="MGLFGGKEPCCICGGKGKNKVLENEYLCNNCFVDFTIFSSERLK
                     TTSAMQVLADHEGIRKFINFSKKNRELLEKFVETNKINKFISIDENNKFIKISDIRKG
                     GDIIETVYATDEIIEFELLEDEESIVSGGLGRAVVGGALFGATGAVVGGVTGKKTTRK
                     IVNTFKIKITFNNINNPLEYINLINTRTKTNSSIYQNACNEAQEILSVLSIIVKNNDK
                     ANNEQDKTSSSIEQVKGLKELLDIGAITEEEFNTKKKELLNL"
     repeat_region   9563..9985
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=9629..9655
                     /rpt_unit_seq="tttacataccacatagttaatataaaa"
     gene            complement(10067..10222)
                     /locus_tag="KNP36_003189"
     CDS             complement(10067..10222)
                     /locus_tag="KNP36_003189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875039.1"
                     /translation="MYENLLDSIDIEKRKEEFRIKLLKIRETDIDIYNKIERVVYKLS
                     EKKIREK"
     gene            complement(10249..10602)
                     /locus_tag="KNP36_003190"
     CDS             complement(10249..10602)
                     /locus_tag="KNP36_003190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875040.1"
                     /translation="MKLLVTKTFFERAGIELPLEVEEKEHFYDTKQIAKKLGLYTMSN
                     KPAFMAVKQIIRKLDIKEDEMKTVLETNGNWTGTVTKYSNKVTEKVKVWLKENNNPIS
                     IKGDKKNYYILYKNN"
     gene            complement(10669..11046)
                     /locus_tag="KNP36_003191"
                     /pseudo
     CDS             complement(10669..11046)
                     /locus_tag="KNP36_003191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012103644.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6N domain-containing protein"
BASE COUNT         3333 a         2112 c         1262 g         4515 t
ORIGIN      
        1 aatgtagttt gtttttttaa tgtaatttca cctttagaat atccgccttt agcatcagta
       61 tgccaagaag aattgttgat acctccagaa gaaccccagc attcaaattt atatttgcca
      121 ggtttcaata taacactttg tggcgaacca ttgtacccaa agttccattc tgtctgcatt
      181 ttctcactct cctctctaac aataagttat caactcattt acacttgttg caatactaga
      241 taaaccacca tttacttttt cttctaaatt aagaaatcta tcttcgattt tcttagatga
      301 ataagtagtc atttcagaca ctctgttatc atccacagtt gcatttataa aatgagtttc
      361 tgcatttcca tttatcaaat atacatacat tttaatattt tcttcatttc taacaagaat
      421 actattatca tcaatagccc tagcgtttgg tgtaagtgct tcaccaattt catcatataa
      481 agctattagt attcttttag tcaatagtgg atgatttata gttacttcat acatattagt
      541 ttcattattt aaaatccaat catcaatctc tataatatgc gtatgagata catttgaacc
      601 acctgcgatt aattggtcaa ttttaatatt ttgtttctca ttttctgtgt caattctagt
      661 atttaactct gttttagttg tatcaatttt agtattaaca gtacctattt tagtttctaa
      721 gtcttgtata tctttgagtg ttgcaaagat tattgttggg tcaattttaa gttctatatt
      781 atttacatta gatacaataa gcacagtttt aaccttcatg tctaccactg caccttgttc
      841 tatagaaggt ttataacact ctttgtattt agaaatggca attaaattat tttcatcatc
      901 taaatatcct atttctctta tcataaatcc gcctacactt gatggtatta aactctctaa
      961 tattatacaa tttggtgcag tttcatctgt agttgtattt ccaatattgc cttcccatac
     1021 cacgtttttg agagctgtct gactctcagt tggagtatat tcactccctc ctccatcacc
     1081 aagttgaatt tttacaaatc ccactttatt acctgtgaca cttgcatttg ctatctttgc
     1141 ttttcctaca tctgtaatta tagtgtaata acttttatct atagccaata tatcacctcc
     1201 taaaatattg ttatctcttg gtatccaact ccattgccag ttaatacatc aatttctcca
     1261 taagtttcta tatctggtgg actccaaggg tatatagtta tttcttgacc cattagggtt
     1321 gttataccaa aattcatata attgtctttg cttataagca ctctagtgta atctaaagtc
     1381 atattacatg gcttaatatt acttacaaaa gaatgaactt cctcaaacca atcttgattt
     1441 ctagcatcac tttcaagatg tatattataa gtagcattat ttatagttaa ctcataattg
     1501 ccttctccaa ctacattatc tagccagttc cttaaaaatc tctctgagta aggtaattta
     1561 cttatatatt tactaaaaat cctaaacctt ctatcttcta aactctcatt acttttagga
     1621 gttatagaca ttatcttttc ccatcttttt atgccacttg gagttaaatc ctctaaaaac
     1681 tggtcatttg ataggtcatt taatttttca tgtagtgttt ttatttcttt gttttctaca
     1741 ttaaatactt ttatatattc ttctttatct cgtaggattt gcggtaagta atttattaga
     1801 ttaatctctt tatccaacta cttcacctct taatactata gaatctttat caacattaag
     1861 attagatgca atgctattta tcattgtatt tgcaatgtct aatactccat caatactaag
     1921 taatctagtt tcaatttgag atatacgaac tattaagttt tcttcatctt cccaactcat
     1981 attaagttca tttaaatagt cgtctattgc ttcttctgca attgatttta tattctccca
     2041 agtgtagcca tttttgtatg ttatctctgc tgatatattt atagttgtac ttgtaactcc
     2101 ttcaactgtg actcggtgtc caattggtgc taatccaaga ccttctcctt ggttttgtag
     2161 aggatcaatt tcttcttgaa ctaaattaac taaatcacta gatggaactt tgaagttaga
     2221 attaattatt actaacttaa cagtacctcc accgtcccac acaggataaa ccttaactcc
     2281 tccaacatct tgtattttgt taacttcatc tttataattt tgcatatttc caccaaaact
     2341 ctgtgagttt aggctatcat aatatctttg tcttaaacta tcttcacttt cttcatcttc
     2401 tccattaatt agtatttcag ttaactcagc agtttctaat ttgtctacat attcaattgg
     2461 aatcaactga ccaagttcaa atacaggtcc agtagtttca catttcattt tatatgtttt
     2521 ttcagatatt ctctcaattg ccacataatt gtattctcct aagttgaatc ttgaatcaat
     2581 aggaatatct atattaaaaa ctccttttgc aattgtattg gttgcaggta aaggtgtaat
     2641 acctctttct ttacatctct tctctaaata gtaataacta gcagtatcta caaaagtttg
     2701 gtctagtaat tcatccatgg caatgtatgt ttctgtaagt tctatagcaa caggagcaag
     2761 agcattatat attatagaac cttccctttt atcaaaagta tctggtacac tatctaacat
     2821 tcttttaatt atattttcaa atgtcattaa ctcaaacaat tatacactca ccaccttctc
     2881 tgcttttata tttccatatt tactgtaaac tgtgaactta caatgtactt taccctttac
     2941 attttgaaac tcaaaattat ctacattttc aaccctatca tcttgaatta gtgcttcttt
     3001 gattcgtctt tcaagttcgg ggattacaaa ggatataggc tctccaataa ggtcgttcaa
     3061 ctcgactcca taattccaac tatatattag atgttggtat ctctctgtgt ttaaaattaa
     3121 aaagatggtt tgttttaatg cttcaacatc atcacaaata ccatctatct tagatttttc
     3181 tatatttaat ttaaaggtct tacttggttc ttgccttaca tcaaaattaa ttatcgatac
     3241 atcttctata tcatagtcaa tgttatctgt tggtaacatt tcatcacatc ctatctaaaa
     3301 tcaaatattg ctgtcctcct tgcatcctaa ttaagactaa tttatctcct atctttttat
     3361 ctgtatatct tttaaatgta tctgtttgta ttagaaaaga ttcttcaaaa gaggcttttt
     3421 gctctatctt aactactaaa ggattaacac tttctatagt tccaaatgca atctgcattg
     3481 ggttgcttgt ttctactgca tccattgcag ctttctttat tatttgtaat aaatcttggc
     3541 tcatattatc acctcactta aaagaatctt ctagctcttg caaaatcatg tttttgtttt
     3601 tgtctaccac ttaaactgct tattttaact acatcaccag tatttggtga atgtatgaac
     3661 ttgtcatttc ctatacatag tccaacgtga tgtacatttc cttttccttg gttgtatgca
     3721 aagaatacta aatcgccagc ttttacatca tttatgttgc ataatagttt tcctctacta
     3781 tcatttgatt ggtctgctga aactcttttg agatttatac ctgcacctct tttgaatgcc
     3841 cacaccataa gaccactaca gtcaaaactc tttggaccat taccacccca tttgtaaggc
     3901 ttgccaagtt gattttttgc ttcttgaata actttattta ctttactatt attgtttgtt
     3961 gatgtattag cattgttgct attttgaact tgataagtta tatcttttaa attcttttct
     4021 gcttcctcgt tgcttctaac acctgtacct gcactattag aactatatgc atttcccgtt
     4081 atttgtttat aaaacttatt tactcctggt acccaatgtt tattaagagg actatcataa
     4141 agtggagcat atttgtctct aatactttct aatgtttttc ttcccatatg gatatagttt
     4201 cttgataaat tacttatacc tctttttatt ccttcatcca cagagccaaa agacattcct
     4261 ttcattccaa agaaattatt tttattttta caaagtgaag aacttccatt accagtttca
     4321 tgtatagaaa tagcagccat taaagctgca ttgactttgt aagcattaga atatttaaca
     4381 aatatacttc ctgtatttga taacttattt ttaaatactt tatttaattt atttatcata
     4441 tcattgtctt ctttacttgt agtactttgt gcaggaccat ttttcttttc atctttatta
     4501 ttagtatttc cactactata tgagcttgaa gaataagaag caaattcatc tccatcaaca
     4561 agagtcaaat ccataaagtg cgaattattt tcaaatgtgt gctttacttt ctcaactaac
     4621 atataatttt gtaaatcaat atctcctaaa tctaaaaaaa caggtactaa acaacctgct
     4681 cttactctaa tatctcctaa cacatttttt aaacttaatg acttagtttt cttattatat
     4741 agttttagaa gtatatcaca tttttgcttt atctctgctt cactcatgtt tttatctact
     4801 gtatcaaaca tttgaagtat tccccaactc ctcatatgtg tagagtcttg tgcaatatat
     4861 acatctcttt tccctgtttc ttcattatct ctcacaagtt taatctttgt gtaagtatca
     4921 ctatctattg atgaattata gtcaaaatcc tcaattacat cattgttcat aacagtatct
     4981 aatttcattg atgcaacatt ctttaatgtt attcttccaa aatcatcata taacacatac
     5041 atttcttttt tctctcttag agtatcatct agtgctgtta gtatcatgtc aaagagtgtt
     5101 ttattttctt ctatcctaga tattttatac ttagtatctt ctatgacatt gtattttaaa
     5161 ttaaaatctt tagctaacat ctttacaagt tcagatgcag tttgattatt atacacataa
     5221 gtatctttat tcttaaaata tctcaactgg tcgtaagcaa caattttgat gtgattttct
     5281 ttatctcttt tcttttgaaa tatatatcca tagaagatac ctattccttt aaaatataaa
     5341 cgaactgaat taccttcaca aaattgcagt atatcatcca tgactattgt aaattctaac
     5401 tttgaaggtg ttcctcgtct ttctatttcc catgtgatac catccaaaac tacaggttcg
     5461 tagaaatctt cccaatgtgc aataactagc cttatatctc tatcattcgc cagaactaaa
     5521 tcatcagaca agcctcaaca cctgcccttt atagatggtg tatttactta atttttttcc
     5581 cttgttagct ttatccatca ttgttttatt taactcatat actttcttgt ataacgaacc
     5641 atttcctaat tgcttttgac aaattgccca aagagaatcc cctgctttta ctgtatatgt
     5701 tttaccattt ggcttattgg atgaatctgg tctaaattct tttggtttca tgactggagg
     5761 gggagtccta ccataatttg tcttttcagg tgttgcaagt actaactttt tagttgagta
     5821 atctctatat tgttttaact ttattgcaac ttttgtatct gaggcatttt ctgcatcttc
     5881 tactatgtta tattcttcta atgacacttt catattagtg ttaaataaga ccttgttacc
     5941 taactcacga gatacaataa attgaaatgg cttacaatct gtctttagta attctagttt
     6001 acttaaaaag aattgaacat ccctaaaaat tccacgataa aatggtagtt tattatgtgt
     6061 aaactctgct tcaaaactta tttcagataa tccttctttt tttagtatgt ttacttctcc
     6121 agtgtttatc aaatcaactg ttttattttt gtttgtcact ttaatttcta acttgggtgg
     6181 agggattggt aattgtactc catctaaata aaagtcataa gccatttaaa cacctcctaa
     6241 actattcctt ctgctgatac aaccatagca tcatttaatt tttcagttag tacattaact
     6301 ataccatcca catctgcatc tttacttatg ttatttgtgt tgttcatatc tatttttatg
     6361 tttactcctg tgaatcggtt tattgtttct tgttctgcta tatctcttaa gtattttaaa
     6421 tcctcttgac ttttatccat tgttttagcc attttagctg tatttcctgc ggtatctttt
     6481 gctccttttg ctgcatcgtt cagtggagag tttagtcccg ctgaacctat tgaatctcca
     6541 agaccatatt ttttgtccca aatgtcgtct aatcctaaat ctttttttgc tttttcggct
     6601 atcttgttaa tatcaaaagt gtcttttaat ttgttttcta aattttgacc cacttcatat
     6661 ccttttttgt aagagtcaaa tgggttttta atgtccatat atggtgcttt ccagtcttgt
     6721 ggctttacag gttcttttag agtcttttgg taatctttat attgttttac aaaagaatct
     6781 actttatcta agcttcctat agtttttata tttatacctg gaattaagtt taacgctttt
     6841 ataactccat ttataccttt tattgctatg tttgctgcac ttacaaaagc atttgctaaa
     6901 gctgtagcac aattgtcaaa acttcctcct acatctccca tggcatttat tacaaagttt
     6961 tggaatttat aaaataacat ctgtacatta tagataacaa tattaaacga attaacaaag
     7021 aactctgcaa atgccattac aatattccat gcacctgcaa agacatcata tatacaagtt
     7081 cctagaaaat aaaaagctcc tacaactact ccagttgcag aaatgcttgt tcctgcaaaa
     7141 tggttaaata ttgctacccc cacaaatatt gctgctataa ctaaggctac tgctgctaca
     7201 accataatca ttgtggcaca taatgttaca ttagctctgc ttactcctaa agtcattaac
     7261 ttgtttataa gcatcgcttt tgtagcaaca tatagttctc cactgagaag cgctgtcaca
     7321 aaacactgtg taaaagtaat tgctgtgtaa attgtttggg ctattaaaac tgaatatatt
     7381 ataactttgt aagcaataaa agctcctaca ataccataga ttacaggcga aataattgac
     7441 caattctgtg caaatacatt agcaacactt agtgcttgtg ttattatcca ccctagccct
     7501 tgtgcaacca gactggctcc aacaatcatc atattaaaaa atccactaaa tgctggacta
     7561 ctcaataaat caattattcc attaaaaaca ctatatccaa cagctcctaa gacatacaaa
     7621 gaatccgtaa cattagttat aaaggttcgg aatcccctac tcgagaccgt gtcctcaatt
     7681 ttcttttgta tagctccaaa tatcattact gcattattct tgatagatgt gaaaatctga
     7741 cctaaagtgt aaggcatttt ttcaaattgt gcattggttt cggctgatgc agcaagtaag
     7801 gaatttttta caatatcagc agtcaacatg ccttcacttg ccattcctct aatttttcct
     7861 atatctacgt ccaaataatc tgcgatactg cggattatgt taggcgctga ctcaaataca
     7921 gcatttaatt cttctcctct cagtacccct gaacccaaac cttgagtcaa ttgtaaaagt
     7981 gctgaattca tttcctcagt acttgcacct gctattacga attttttgtt aagttgttct
     8041 gcaaaactta ctatttctct agtgctagaa aatgcacttc ctgcattcat acctatcctt
     8101 gagactatct gtgcggtatc caaataagat gcacgagacc tctcagctga ttggaaaatc
     8161 atcttattta aaccactatc agataattga ccatcattta tcatcgccaa cctcgcattt
     8221 gtactggtca tttggtcgct taaactacct aaacctccta ttgtctttaa acccatataa
     8281 gctccagcaa tctttttaac acttccaagt aaattatttg tagaacttgc tcctttatta
     8341 atatcctcgt taaactttct ttgttgttca tctgcttttc ctatgttttg ttctattctt
     8401 gttaaaatat tttctatgtt atttaaactc tgctgagatg tctgtatccc acctgtattg
     8461 agcggattat tcaatctccc ttgtagtctt tctagactat taattgtcgt attaatagat
     8521 gctgtcatac tcctaaatgc aggtgtcatt ccatcgaaaa ttcggataga tgtttgtata
     8581 gttgccattt tatcactctc ctttcataaa tttccatata aaaaaaacac ttacttttgt
     8641 aagtgtctag ttattataaa tttaataatt cttttttctt agtattaaat tcttcttctg
     8701 ttattgctcc tatatctagt agctctttca atccttttac ttgctctatt gaactactag
     8761 ttttatcttg ttcattgtta gctttatcat tgttttttac aattattgaa agtactgata
     8821 aaatctcttg tgcttcatta caagcatttt ggtatataga tgaattagtt tttgtccttg
     8881 tattaatcaa attaatatat tctaaaggat tattaatatt attaaatgtt attttgattt
     8941 taaatgtatt gacaatcttt cttgttgttt ttttacctgt tacacctcca actacagctc
     9001 cagttgcacc aaataaagca cccccaacta cagctcttcc taaaccacca ctaactatag
     9061 actcttcatc ttctaaaagt tcaaactcta taatttcatc agttgcatat acggtttcta
     9121 ttatatctcc gcctttacga atatctgata ttttaataaa tttattattt tcatcaattg
     9181 atatgaattt attaatttta tttgtctcaa caaatttttc taatagttct ctatttttct
     9241 tagaaaaatt tataaacttt cttattcctt catggtctgc taatacttgc attgcactag
     9301 ttgtttttaa tctttcacta gagaatatcg taaaatcaac aaagcaatta ttgcacagat
     9361 attcattttc taaaacttta tttttaccct ttcctccaca tatgcaacat ggttctttac
     9421 ctccaaataa tcccataata ttacccccta cgcaatttta taagattatt atactatatt
     9481 agtaaaattt ttacatcata atcacctcct ttcaattaaa aaagcactta ctcatttgta
     9541 agtgtttttg aattattttt aattttaagt ccacatagtt aatataaaac cctttataga
     9601 taattttata gactctttgt atgtactatt tacataccac atagttaata taaaatgaaa
     9661 agagtttgta gggaaaatat ttaatgatgc aacctttaca taccacttag ttaatataaa
     9721 acaagaacta gctacaagct ttatacagcg ttctcaaacc tttacatacc acatagttaa
     9781 tctaaaaccc tctttatttt tagagaacat ccactttgtt atattattta cataccacat
     9841 agttaatata aaactaggat agaacagaaa attggaagaa atacaaatga acatttacat
     9901 accacatagt taatataaaa ttttcttttc ttctactgta gtcgcattaa ttccagcctt
     9961 tacataccac ttagttaata taaatcccta cttccattat accattttat accaaataaa
    10021 gcacttgaaa caacataata tccaagtgct ttatctattt atttaattat ttttctctaa
    10081 tttttttctc agaaagttta tatactactc tttctatctt attatatata tctatatctg
    10141 tttctcttat tttcaaaagt ttaattctaa attcttcttt tctcttttca atatctatac
    10201 tatcaagtaa attctcatac attgtattac ccccccaaaa actaaaatct aattattttt
    10261 atacaatata tagtagtttt tcttgtctcc tttgattgag ataggattat tattttcttt
    10321 caaccacact ttgacctttt ctgtaacctt attagaatat tttgttacag taccagtcca
    10381 attgccattc gtttctaata ctgttttcat ttcatcttct ttaatatcaa gctttcttat
    10441 aatttgctta actgccataa atgctggttt attagacatt gtgtaaagtc ctaatttttt
    10501 tgcaatctgc tttgtatcat aaaaatgttc tttttcttca acttcaagtg gcaattcaat
    10561 acctgctctt tcaaaaaaag tcttagttac aagaagtttc atacttttat caatgtttaa
    10621 atcatcaaaa attggagtta ttaacctaat tgactcatta actgtttcta atttttctaa
    10681 tgctttcatt tctttctttt cttctttaac tctaaaataa ctatttacca attgtctttg
    10741 tactttccaa gctaaatcat ctgtaaaaga tttcactaac atcaaatagc ctgtttcagt
    10801 tattaaagtt aatccacgat taggaatttc taaagtacga tttccgtact tttcaaaatc
    10861 acttgctttt acaaaaaaga aatcttcgtt ctctataaaa tgttttctat tctctgagaa
    10921 atttctcttt gctgtacctt ctgttctttc atgtacttgg tcaatttctt taaatgtaac
    10981 tactctttga ttattaaact ccttgacctg caactcttgg ttgttaatta atactaaatt
    11041 gttcataaaa acacactcct taataattga ttttttttaa ggaatgacat ataattatat
    11101 tacatattag ttatatgtca taaggaatat ttaaactttg acgagagaga atattcctta
    11161 ttttatccct tattacttta tctttataaa gatttcttta tctttatatt ctaataatac
    11221 at
//
LOCUS       DAEHWM010000108        11180 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.111, whole genome shotgun sequence.
ACCESSION   DAEHWM010000108 DAEHWM010000000
VERSION     DAEHWM010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 11180)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11180)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11180
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.111"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(80..955)
                     /locus_tag="KNP36_003192"
     CDS             complement(80..955)
                     /locus_tag="KNP36_003192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875041.1"
                     /translation="MSSSIKIENLSHSFKKQNIFNNMSLSFEKNKIYGLLGKNGAGKT
                     TLLNIMVNQLIQNEGEIEILGKNPKEDIKVLEEVCIVREKEFYSPDFKVGQIFEFSSS
                     FYKSYDKGLEEELCKYFDLNTKKKYKQLSRGMKTILSNIIGICSNSAITIFDEPTIGL
                     DAVNRQEFYNIILDSYIKNPRTIIISTHLIDEIDDLLEHVIILNEGKIIIDEEIDVIK
                     QKAHYITGNKEELEKLECIKNIKPKKAFGNAVAYFYYGDFSESDEKILKNSNIDVGYI
                     GLQDMFVNMTKKEEL"
     gene            complement(959..1327)
                     /locus_tag="KNP36_003193"
     CDS             complement(959..1327)
                     /locus_tag="KNP36_003193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0875042.1"
                     /translation="MKLVLNNEEPIFIQIARAIEDEILSNGIKEEEQVPSTTELSKLY
                     KINPATVLKGINILVDKNILYKKRGIGMFVSDGAKTIIKEARKENFKHNFVKNLLQEA
                     NKLEINREELVDIIINFKED"
     gene            complement(1510..2169)
                     /gene="deoC"
                     /locus_tag="KNP36_003194"
     CDS             complement(1510..2169)
                     /gene="deoC"
                     /locus_tag="KNP36_003194"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HBF0875043.1"
                     /translation="MKHILKTVDHTILKATTTWEDIKILCDEAVDMSVASVCIPPSYV
                     KRASEYLKGKIKICTVIGFPLGYQTTATKVFEAKDAIENGADEVDMVVNISDIKNKDY
                     DNIGKEIKEIKKAIGDKVLKVIIETCYLDEDEKIKMCEIVTMSGSDFIKTSTGMGTGG
                     ATLEDIKLMKEHVGKNVKIKAAGGVKSISDAEKFIEAGAERLGTSSICKILKNEDTTD
                     Y"
     gene            complement(2205..3392)
                     /gene="murJ"
                     /locus_tag="KNP36_003195"
     CDS             complement(2205..3392)
                     /gene="murJ"
                     /locus_tag="KNP36_003195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="HBF0875044.1"
                     /translation="MKQEPCDFSHGRFRTGIIFIGITSVMSAFLQIKENFIVVGFGSI
                     PYNIVIIISIMLSTIFGPYILPIGAVVAMVVQLLFYMFFVKKTNYKYLYYLNFKDDSL
                     IKLLALLSPVFIGVAVNQVNSLVDTTLASTLVKGSIPALTYADRLNGFVTGTFTASIV
                     SVMYPMLSKLSAENNQKKFTSSVKSSINMIIISMIPISVASIFFATPVVRIIFERGAF
                     DARATQMTATALIFYAVGMTAFGLRDILGKVFYSLQDTKTPMVNGIISVGVNIVLDLV
                     LIKPMAHGGLALATSSSSIACILLLFLNLKRKVGYFGQDKIIKATLKSVVASLIMGVL
                     SYFTYKFIFGILGVGTFNEFVSLAISVIVGGGIYTLLMIIFKVEEVDMILNIAKRKLH
                     LKK"
     gene            complement(3469..4587)
                     /locus_tag="KNP36_003196"
     CDS             complement(3469..4587)
                     /locus_tag="KNP36_003196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0875045.1"
                     /translation="MIAVKKAYKFRMYPNKKQQELINKTFGCCRFVYNKYLAKRIDVY
                     KNDKETFTYKQCSSDLTNLKKELKWLKEPDKFSLQNALKDLDNAYKKFFKEKAGFPKF
                     KSKKINRFSYKTNFTNGNIMYCGQHIKLPKLGMVKIRDKQVPKGRILNATISKEPSGR
                     YYVSLCCIDVDIEVFENTNNHIGLDLGIKEFCISSCGEFIENPKYLKKSLNKLAKLQR
                     ELSRKTIGSLNRNKARLKVARLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNM
                     IRNRKLSRLISDVSWSEFIRQLEYKANWYGRQIVKVGKFFASSQICNKCGYKNEEVKN
                     LNIREWICPSCNETHDRDINASINILKEGLRLITIQNK"
     gene            complement(5236..5643)
                     /locus_tag="KNP36_003197"
     CDS             complement(5236..5643)
                     /locus_tag="KNP36_003197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875046.1"
                     /translation="MSKVAKATFYLMIVTIISKILGMGRELVLSSIYGTGLYTESYLT
                     AMNIPNIIFAAIGTAIVTTFIPMYQDISSKQGEKQALKFLNNVLNIIVGICIVVAILG
                     VIFSKQLVSIFAIGFEGERFLLTVKFTKILIKK"
     gene            complement(6117..7001)
                     /locus_tag="KNP36_003198"
     CDS             complement(6117..7001)
                     /locus_tag="KNP36_003198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889336.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0875047.1"
                     /translation="MDTKKENNYENYICVGSSNVSNAMKMYLKEIEEYKMLSAGEEVE
                     LAKEIINSSSVAKEKFINSNYRLVVSIAKRYKRDSIDMLDLIQAGNIGLIKAVEKYDY
                     KKGYKFSTYATWWIKQSITRYIDDCENTIRIPIHLHQRINFVKKKKQELLNVLLREPT
                     IDEIADACGLEVDKVLELLRRDKNVVSLDTPLKEDEDSSLVEFIPSDADFKDVVIHEV
                     EQHNLKEKIEELLTGLGEQEQQVLRMRFGIDDDDPKTLEQIGKVFGVTRERIRQIEAK
                     AIRKLRHPSKLKQLKHFY"
     gene            complement(7292..7768)
                     /locus_tag="KNP36_003199"
     CDS             complement(7292..7768)
                     /locus_tag="KNP36_003199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction enzyme HsdR N-terminal
                     domain-containing protein"
                     /protein_id="HBF0875048.1"
                     /translation="MSKELVKDRVIKYLIEDLLVPQDMIDTNVELAEFEEGAEGILDI
                     VVNVKDEEDYYAPVMIVQCLDEDVELEGEVLQKQIEFLEEVDNITMSGRLVLTNGDAM
                     MYADWRGEEYDTEAALPTYDIMVKEFHEMEQQVKDLEEHHHHDENCGCGCNHHHEN"
     gene            8034..9209
                     /locus_tag="KNP36_003200"
     CDS             8034..9209
                     /locus_tag="KNP36_003200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HBF0875049.1"
                     /translation="MKFKKQISSIVVSTMLVLGSMNLSYADGTNVVTLGANLSESQKQ
                     QMLNYFGVKKDQVLVLDVTNAEERQYLQGVATEGQLGKVTISCSYVEPTKKGNGINVK
                     TANLTWVTSSMIASTLTTAGLEDANVIAAAPYPVSGTGALTGIMKAFEDASGKKLDET
                     KKEIASEELVVTGDLGDDIGQEKATGVMNDIKTEIVKNGTKDTNQIANTINNVVNNYN
                     ITITPEQKEQIKGVMKKIADQNYDYNSMKNTLDNVSDNVNEQLKKLGESVKGSGILDT
                     IGGWFSGIGDWFSGLFSGGDKKDLGILNNTNDESLGSDAVINSTEGVQINPQNNTNSN
                     NDSDTNSSKNDTSSNNENNDSSQTNENNTTNNSENQSNNNDSVGFFEKIKNWLSGLF"
     gene            complement(9290..10093)
                     /gene="proC"
                     /locus_tag="KNP36_003201"
     CDS             complement(9290..10093)
                     /gene="proC"
                     /locus_tag="KNP36_003201"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HBF0875050.1"
                     /translation="MKKIGFIGAGNMASAMIGGIVNSKLVEPNMVIASAYSQGTLDRI
                     DANFGINTTKDSKEVTRTSDIVIVAVKPDIYDDILEEIKDFIDDNKIIVTIAAGKSIK
                     DIESIIGEDKKIVRTMPNTPALVNEAMSSLSINKNINKEDLEAVTEVFNSFGNTEVVP
                     EYLIEAVIGASGSAPAYVFLFIEAIADAAVIAGMPRPQAYKFASQAVMGSAKMVLETG
                     KHPGELKDMVCSPGGTTIEAVKVLEEEGFRASVIKAICACIEKSKKMSE"
     gene            complement(10133..10717)
                     /locus_tag="KNP36_003202"
     CDS             complement(10133..10717)
                     /locus_tag="KNP36_003202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875051.1"
                     /translation="MNKDIGAKIKQLRTQKQMTLKDMSEKTNLSIGFLSQLERGLTSV
                     ATDSLGKIASVLDVELTYFFMKPKEHKRAVLRSYEKEVFDVENSTFIHYHLSSSLKEK
                     TMLPRLIEILPSKSSEEICCYVHEGEEFVYVLEGTLTVFLGDEQIEMYPGDTIHYNSE
                     KNNHNWVNYTNKVVKILVVSIPNPFEKSDAVKEA"
BASE COUNT         3630 a         1909 c         1200 g         4441 t
ORIGIN      
        1 ttcccacaat cataaatata attatataca atttagtatt tttattaaaa aattttatat
       61 atggctttaa ttcattcaat tacaattcct ccttcttagt catgttaaca aacatatctt
      121 gtagccctat gtatcctaca tcaatatttg aatttttaag tattttttca tcactttcac
      181 taaaatcacc atagtaaaaa taagcaactg catttccaaa tgccttttta ggttttatat
      241 tttttataca ttctaatttt tctaactctt ctttatttcc agtaatataa tgagcttttt
      301 gttttatgac atcaatttct tcatctataa taatttttcc ctcatttaat attattacat
      361 gctccagtaa atcatctatt tcatcaatca aatgagttga tattattatt gtccttggat
      421 tttttatata actatctaaa attatgttat aaaactcttg tctatttact gcatccagac
      481 caattgttgg ctcatcaaat atggtgatag ctgaattaga acaaatacct attatatttg
      541 aaagtatagt tttcatacct cttgacagtt gtttatactt ttttttagta tttaaatcaa
      601 aatatttgca taattcttct tctaagcctt tatcataact tttataaaaa ctagaagaaa
      661 attcaaatat ctgacctact ttaaaatctg gactataaaa ttctttttcc ctaacgatac
      721 aaacttcttc caaaactttt atatcttctt ttgggttctt tcctaatatt tctatctcac
      781 cttcattttg aattaactga tttaccatta tatttaataa tgttgttttt ccagctccat
      841 tcttacctaa taaaccatat atcttatttt tttcaaagct tagagacata ttattaaaaa
      901 tattttgctt cttaaaactg tgagataaat tttctatctt aatagaacta ctcatatatt
      961 aatcctcctt gaaattaatt ataatatcaa ccaattcttc tctatttatt tctaatttgt
     1021 tagcttcttg aagtaggttt tttacaaaat tatgtttaaa attttctttt ctagcttctt
     1081 ttataatagt ttttgcacca tctgatacaa acatccctat ccccctcttc ttatataaaa
     1141 tatttttatc aaccaatata tttatacctt ttaatactgt agctggatta attttataaa
     1201 gctttgaaag ctctgttgtt gatggaacct gttcttcttc ttttattcca tttgatagta
     1261 tctcatcttc aattgctcgt gctatctgaa taaatatagg ttcttcatta tttaatacta
     1321 atttcatagg ttcctccttt ctccatcagt tagttactca actaattaac tatataactt
     1381 ataatatctt gaaaaatatt ttctgtcaat actaaataaa aaacagaggg aaaattccct
     1441 ctgttttttg ttctttatat ttataattaa attttgattt ttgtaatcct atcccataag
     1501 ttaaaaactt taataatctg ttgtatcttc attttttaat attttacata ttgagctagt
     1561 tcctaacctt tctgctcctg cctctataaa tttttctgca tcagaaattg atttaactcc
     1621 ccctgcagct tttattttta cattttttcc aacatgctct ttcataagtt ttatatcttc
     1681 taaagtagct ccacctgttc ccattccagt agatgttttt ataaaatctg aacctgacat
     1741 tgttactatt tcacacattt ttattttttc atcttcatct aaataacatg tctctataat
     1801 gacttttaat actttatctc ctatagcttt ttttatttct tttatttctt ttcctatatt
     1861 atcataatct ttatttttta tatctgaaat gtttacaacc atatcaactt catctgctcc
     1921 attttcaata gcatcttttg cttcaaatac ttttgtagca gtagtttgat atcccaaagg
     1981 gaaccctatc actgtacata tctttatttt accttttaga tattctgatg ctcttttcac
     2041 atatgatggt ggtatgcaaa ctgatgctac actcatatct acagcttcat cacataaaat
     2101 tttaatatct tcccatgtag ttgtagcttt taaaatagta tggtctactg tttttaatat
     2161 atgtttcata aaatcctcct aaatttataa ttaatataat tagattactt ttttaaatgc
     2221 aattttctct ttgcaatgtt tagtatcata tcaacctctt caactttaaa aataatcatt
     2281 agtagtgtat aaattccacc tccaactata actgaaatag ctagtgatac aaactcatta
     2341 aatgttccta ctcccaaaat tccaaatata aatttatacg taaagtatga taaaacaccc
     2401 ataattaaag atgcaactac cgatttcaaa gttgctttta ttattttatc ttgtccaaaa
     2461 tatccaactt ttctctttag gttcaagaag agtaacaata tacatgcaat tgatgatgaa
     2521 ctagttgcaa gagcaagacc accatgagcc attggtttta ttaaaactaa gtccaatact
     2581 atatttaccc ctacagatat aatcccattt accataggtg tttttgtgtc ttgtaatgaa
     2641 taaaaaacct ttcccaaaat atctcttaag ccaaatgcag tcataccaac tgcataaaaa
     2701 attaaggcag ttgctgtcat ttgggttgcc ctcgcatcaa aagcacctct ctcaaaaatg
     2761 attctaacaa caggagttgc aaaaaaaata gaagcaactg aaataggaat catagaaatt
     2821 attatcatat ttatactgga tttaactgaa ctagtaaact tcttttgatt attttctgca
     2881 cttaacttag ataacatagg atacataaca gatactattg aagctgtaaa tgtccctgta
     2941 acaaaaccat ttaatctatc tgcataagta agtgctggaa tgcttccttt aactaatgtt
     3001 gaggctaaag ttgtatctac caatgagttc acttgattaa cagcaacacc tataaatact
     3061 ggtgaaagta atgctagtaa tttaataagg ctatcatctt taaagtttaa gtagtataag
     3121 tatttgtagt tcgttttttt aacaaaaaac atgtaaaaga gcagttgaac taccatagca
     3181 accacagcac caattggaag tatgtatggt ccaaatatgg tacttaacat tattgaaata
     3241 attattacta tattataggg tatacttcca aatccaacta caataaagtt ctctttaatt
     3301 tgtaaaaatg ctgacataac actcgtaata cctatgaata ttattcctgt tctgaacctc
     3361 ccatgactaa agtcacaggg ttcctgcttc atagaatttt gcatactaaa atatgtctta
     3421 ctaattctcc acaggctatc cccgtagttc ctacggttct tacatacgtt atttattttg
     3481 aattgttatt agtcttaatc cttcttttaa tatatttata cttgcattta tatctctatc
     3541 gtgagtttca ttacaactag gacaaatcca ttctcttata tttaagttct taacttcctc
     3601 gtttttatac ccacatttat tgcatatttg tgaacttgca aagaatttac ctacctttac
     3661 aatttgtcta ccataccaat tagccttgta ttctaattga cgaataaact ctgaccatga
     3721 tacatcagaa attaagcgag atagtttacg atttctaatc atattcttta cttgtaaatc
     3781 ttctatgcaa ataatatcgt tctcttttat taatttagta gatagttttt gtagaaaatc
     3841 atttctttga ttagctatat gttcttgaag tcttgcaact tttaatcttg ctttatttct
     3901 atttaaacta ccgattgttt ttctcgataa ttctctttgt aatttagcaa gtttgtttaa
     3961 tgacttctta agatacttag gattttctat aaattctcca caacttgaga tacaaaattc
     4021 tttaattccc aaatctaaac ctatatgatt attagtattt tcaaatactt caatatctac
     4081 atcaatacag cataatgata cataatatct accacttggt tctttagata tagtagcatt
     4141 aagtattctc cctttaggta cttgtttatc ccttatctta accataccaa gtttaggtag
     4201 ttttatatgt tgaccacaat acataatgtt tccatttgta aagttagttt tatatgaaaa
     4261 tctattaatt ttctttgatt taaatttagg aaatcctgct ttttctttaa agaatttttt
     4321 atatgcatta tctaaatctt ttaaggcgtt ttgtagtgaa aatttgtcag gttctttaag
     4381 ccattttaat tcttttttta aattggtcaa atcagaacta cactgtttat aagtaaaagt
     4441 ttctttatcg tttttataaa catctattct tttagcaaga tacttattat atacaaatct
     4501 acaacatcca aaagttttgt taattaactc ttgttgtttt ttatttggat acattctaaa
     4561 cttataagct tttttcactg ctatcacctc actttaattg ttttttgata cactttttaa
     4621 tgattttatc acattttatc acatttaata tattatataa tgctgtggtg aacaatttat
     4681 taatcaccta taataatgtt aacaaatgta attatttaaa acaattattt agaaggtttt
     4741 atatttaatt ttaaataaca tatttaagaa ccgtaagtct taacttttat catttttgag
     4801 gttgtcgttc acataagttc gctactacct atgcagttct cttatgaact tcttacactt
     4861 tcatgtaagc acagactata tcttatcctt cagcattatc cgttaaggtc tacccacttc
     4921 cactaccaat agcttgtagt gtacttccct caagaggaat agtcgttgaa gtttctccta
     4981 ttcggagttt acctgctgat tgcccatttt aaagtactta ggatttaacc ttataccatc
     5041 taaccaattt tttctacttt cgtaactttc acacttaggt ttatttcatc cttatgtttt
     5101 agtttgatta gctttaggga tttccagcaa ttcaagtagt attggatagg ttctatccta
     5161 tctctacata taggtttccc tatatgctga ctattttagc tactaactca tgactaaagt
     5221 cacgagtgtg cgtagctatt ttttaatcaa tattttagta aattttacgg taagtaaaaa
     5281 cctctctcct tcaaatccta tagcaaatat acttacaagt tgctttgaga aaataactcc
     5341 taatatagct acaactatgc atataccaac tattatattt aaaacattgt ttaaaaactt
     5401 tagtgcttgc ttttcacctt gtttactact tatatcttga tacattggaa taaaagtagt
     5461 aactatagca gtacctattg ctgcaaatat aatatttggt atattcatag ctgttaaata
     5521 actctctgta tataagcctg taccataaat tgatgataat actaattctc tacccattcc
     5581 aagaatctta gagattatag taactatcat caaataaaaa gttgctttag ctaccttgct
     5641 cattttatca ctccacttct aacatacctc tttttaatca agtaaaattt agctcattag
     5701 atataattct atcaactaat ttgccttgct tagccctatc aaaatataat taacacctat
     5761 ttcttaatat atcacaaact acattattct tcatattttt ttatttctcc aataagtttt
     5821 acatttttcc tatataaatt gtatagcttc aattatattc aaagaaatgg agttgctacc
     5881 cgataacttt aaaagtaaaa aacagatttt attatctttt taaactatat tctaacatat
     5941 tttgtccata ttgagaaatt ttactaaact attatgtact ttattaaata aataaaataa
     6001 cagcacacct ataaaataca agtgtgctgt tcataaacag attttataaa aaaataattc
     6061 ctaagtagag attaacatgc tttctcatac tctcatatat aatgtgtcta aaaatattaa
     6121 taaaaatgct ttaattgttt taacttactt ggatgtctta attttcttat tgctttagct
     6181 tctatctgtc ttattcgttc tctggtaact ccaaatacct ttccaatctg ttctagtgtt
     6241 ttagggtcat catcatcaat tccaaatctc attcttaaaa cttgctgttc ttgctctcca
     6301 agacctgtaa gtagttcttc tatcttttct tttaaattat gctgttcaac ttcgtgtatt
     6361 acaacatctt taaaatcagc atctgatggt ataaattcaa ctaaactact atcctcatct
     6421 tcttttaatg gagtatccaa agatacaaca tttttatctc ttcttaataa ttccaacact
     6481 ttgtcaactt ctaagccaca tgcatctgca atctcatcta tagttggctc tcttaataat
     6541 acatttaaaa gttcttgttt ctttttcttt acaaaattta ttctctgatg aagatgtata
     6601 ggtatcctaa tagtattttc gcaatcgtcg atatatcttg ttatactttg ttttatccac
     6661 caagttgcat aagtgctaaa tttgtatcct tttttataat cgtacttttc tacagctttt
     6721 ataagtccta tatttcctgc ttgaattaaa tccaacatat caatactatc tcttttatat
     6781 ctctttgcta tgctcactac caacctataa tttgaattta taaatttttc ttttgctact
     6841 gaagatgagt tgattatttc cttagccagc tctacctctt ctcctgctga caacattttg
     6901 tattcctcta tttcctttaa atacattttc atcgcattcg atacatttga tgaacccaca
     6961 caaatataat tttcataatt attttctttt ttagtatcca taatcaaacc ccttctattc
     7021 atagaatttg ctaaaacaaa aataaataat ttaaacctac ataatctaca attacataat
     7081 atcccattct ttaaatgaat tgttttgtat attatgtata caaatttata aaaactatac
     7141 ctataatatt attctacttc taacagcaat atcctcctta tatatataat ttattttatt
     7201 atatgttgtt atattcttag ttttttgaat gatatatgtc taaaaaaaga ctgtttacta
     7261 aacagtcttt ttttatatat atgctcaata tttaattttc atgatgatga ttacatccac
     7321 atccacaatt ttcatcatgg tgatgatgtt cttctaaatc ttttacctgt tgttccattt
     7381 catgaaactc ttttaccatt atatcataag ttggaagagc tgcctcagta tcgtattctt
     7441 cccctctcca atcagcgtac atcatagcat ctccattagt taaaaccaat ctacctgaca
     7501 tagttatatt atccacttct tctaaaaatt ctatttgttt ttgtaaaact tctccttcta
     7561 actccacatc ttcatctaaa cattgcacta tcattacagg tgcataataa tcttcttcat
     7621 ctttaacatt tacaacaata tctaaaattc cttctgcacc ttcttcaaat tctgccaact
     7681 caacatttgt atcaatcata tcttgaggta ctaataaatc ttctattaaa tattttatta
     7741 ctctatcttt tactaattct tttgacattt atttttctcc ttccgattct ataacattat
     7801 cataatcatt tctatattat agtatactac attaattgtt ttttcaatct cttacaaaaa
     7861 ttatttttta ttatcttcct tatattccct tttttattac aaagttgtaa tcgcattgat
     7921 ttaaaaaata gtttatattt agtataatag aaatgtagca catattttta ttcaatatat
     7981 taataaaaaa atatattgaa aatgtaatgt atgttaaatc taggaggaat attatgaagt
     8041 ttaaaaaaca aattagttct attgttgtgt ctactatgct tgtacttggg agtatgaacc
     8101 tttcttatgc agacggtaca aatgtagtta cacttggagc taacttatca gagtctcaaa
     8161 agcagcaaat gcttaattac tttggagtaa aaaaagacca agtcttagtt ttagatgtaa
     8221 caaatgcaga agaaagacag tatttacaag gtgttgcaac agagggtcaa cttggaaaag
     8281 ttactatctc ttgctcatac gttgaaccta ctaaaaaagg aaatggaatt aatgttaaaa
     8341 cagcaaactt aacttgggta actagttcaa tgattgcttc aacccttaca acagctggtc
     8401 ttgaagatgc aaatgttatt gctgctgctc catatcctgt aagtggtact ggagcattga
     8461 caggaatcat gaaagcattt gaggatgctt caggaaagaa acttgatgaa actaagaaag
     8521 aaattgcttc tgaagaattg gtagttacag gtgacttagg agatgatata gggcaagaaa
     8581 aagcaacagg tgtaatgaat gatataaaaa cagaaattgt aaagaatggt acaaaagata
     8641 ccaatcaaat agcaaataca ataaataatg ttgtaaataa ttacaatatt actattacac
     8701 cagaacaaaa agaacaaatt aaaggtgtaa tgaaaaaaat agctgaccaa aattacgatt
     8761 acaatagcat gaaaaataca ctagataatg tatcagataa tgtaaatgaa caattaaaga
     8821 aattaggtga aagtgttaag ggttctggta tactagatac tattggtgga tggtttagtg
     8881 gaataggaga ctggttctct ggtttattct caggcggaga taaaaaagat ttgggaatct
     8941 taaataatac taatgatgag tctcttggct ctgatgctgt aataaattct acagaaggtg
     9001 ttcaaataaa tccacaaaat aatactaatt ctaacaatga tagtgataca aatagctcaa
     9061 aaaatgatac ttcaagtaat aatgaaaata acgatagttc tcaaacaaat gaaaacaaca
     9121 caacaaataa ttcagaaaat caatcaaata ataatgactc agttggtttc tttgaaaaaa
     9181 taaaaaattg gctttcaggc ttattttaga aattaaacaa ataaaaagaa ttgcctaaaa
     9241 tggaaatttt ctataaaagg caattctctt tatttacaat aaatttttat tactcactca
     9301 tttttttaga tttttctata catgcacata ttgcttttat cacagaagct ctaaaacctt
     9361 cttcttcaag tactttaact gcttctatag tagttccacc aggtgaacat accatatctt
     9421 ttaattcacc aggatgtttt cctgtctcaa gtaccatttt tgcagaaccc ataacagcct
     9481 gtgatgcaaa cttatatgct tgtggtcttg gcattcctgc aattactgct gcatctgcta
     9541 tagcttctat aaataaaaat acatatgctg gtgcagaacc acttgcacca attacagctt
     9601 ctataagata ctctggtact acctcagtat ttccaaaaga attaaatact tctgtaactg
     9661 cttctaagtc ttctttgttt atatttttat ttatcgaaag agaagacatg gcttcattta
     9721 caagagctgg agtatttggc atagttctaa ctattttttt atcttctcct ataatagact
     9781 ctatatcttt tatagatttt cctgctgcta ttgtaactat aattttattg tcatctataa
     9841 agtcttttat ctcttccaaa atatcatcat atatatctgg tttaacagct acaattacta
     9901 tatcagaggt tctagttact tccttcgagt cttttgtagt atttattcca aaatttgcat
     9961 ctattctatc gagagttcct tgactatatg ctgatgctat aaccatatta ggttcaacta
    10021 attttgaatt tactattccc cctatcatag cgcttgccat atttcctgca cctatgaatc
    10081 caattttttt cactttagta cctccttatt gactaatagt aatcgttaaa atttaagctt
    10141 ctttaactgc atcagatttt tcaaatggat ttggtatact tactaccaaa attttcacta
    10201 ccttattagt atagttgacc caattatgat tgttcttttc actattatag tgtattgtgt
    10261 ctcctggata catttctatt tgttcatctc ccaaaaacac tgtaagagta ccctctaata
    10321 catacacaaa ttcctcacct tcatgtacgt aacaacaaat ttcctcacta ctcttacttg
    10381 gaagaatttc aattaatctt ggtagcattg ttttttcctt taaactagat gataaatgat
    10441 aatgtataaa tgttgagttt tctacatcaa atacttcttt ttcataactt cttaatacag
    10501 ctcttttatg ctcttttggc ttcataaaaa agtaagttaa ttctacatct agtacacttg
    10561 ctatttttcc taaggaatct gttgccacac ttgttaatcc tctttcaagt tgtgataaaa
    10621 aaccaattga caagtttgtt ttttcactca tatccttcag cgtcatttgc ttttgagttc
    10681 tgagttgctt tatttttgct cctatgtcct tattcaaaac catcacccct aaataatttt
    10741 aattttttca taatataaat acaaaaatat aaatataggt actgaaccca tctttatttc
    10801 atttaaaaaa atttttataa gtattactat aatttatcaa tctttttttg tctacatttt
    10861 tacgattatt tacgatttat ttttcacata tgtatattta atcttgccaa ctaaagatac
    10921 attttttata agcatttact ctttatataa taaaacttaa gttgttcatg tagtcttctt
    10981 ctggtttaat tattaaaatt tcaaattata ttattatttc tacacattat tacatccttt
    11041 agtacaatta taacataatt ttacaattta atgatatcta ttcaatgtct ttttttactc
    11101 tacaacatat tttattttag agtttaatac tatatatatt ttttatatac agccttgtca
    11161 ttttttagat tgtcaagagt
//
LOCUS       DAEHWM010000109        10861 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.112, whole genome shotgun sequence.
ACCESSION   DAEHWM010000109 DAEHWM010000000
VERSION     DAEHWM010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10861)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10861)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10861
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.112"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            387..1166
                     /locus_tag="KNP36_003203"
     CDS             387..1166
                     /locus_tag="KNP36_003203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HBF0875052.1"
                     /translation="MSYKKIAIITGANSGFGKEFLKLLINEEEITEIWAVARNKARLN
                     QLVDEFGSKVKIFSKDLSKIEEVKEIGTFLSKENVCIKYLINNAGFAKFCSYNDLSID
                     ESINMIDLNISAVVALGLICIPYMQKGSHIMNISSQASFQPLPYQNIYSSTKAFIRNY
                     TRALNVELKSKGINAIAVCPGWMSTNLFKRGIVVAEKGTKNFPGIVSPDVVAKKALKD
                     AKKNKDISVYGINTKSSHLLAKLLPQKMMMKVWLMQQHIKE"
     gene            complement(1476..2297)
                     /locus_tag="KNP36_003204"
     CDS             complement(1476..2297)
                     /locus_tag="KNP36_003204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002572585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallohydrolase"
                     /protein_id="HBF0875053.1"
                     /translation="MKLKIVGSGGMSIIPSSFCKCKICEEARQKGGRYERLGPSLYID
                     DIKMLIDTPEDIAVACNRQKISEVKHISISHHDPDHVKGIRIVEKIGCDFITGENNPI
                     GFYALPEVIEDINRTNLDCLKYYGDVINCISINETSHVKINNFDIDLINNNPDRNITF
                     YVIKENEKKVIYACCNPKPFTHSDMYFDADILIISLVSDDGILNDGTKLKDTPFKDEI
                     FTLDEIVEIKNYYRIKKIIVTHIDEMWGKSYGYYSELEKKLDNIYFAYDGMEIIV"
     gene            complement(3307..4125)
                     /locus_tag="KNP36_003205"
     CDS             complement(3307..4125)
                     /locus_tag="KNP36_003205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0875054.1"
                     /translation="MFKIGDFSKLSKISIRMLRHYDEIGLLTPSHTNKTNGYRYYSAD
                     QLSTTNRIHALKDMGFGLYSIKEILTEYNDKESLIKYLNIHHSQVKEQLEDTQKKLLK
                     IETTIKRIGGNDIMKNYDVTIKNFAPKYMMTLRRVIPTYQDEGMLWHQAFLETKDQNV
                     QIEPPKYSKAVFYDTGYKEDYVDVEVQVAVSGKYKDTEHVKFKTVPSVTAATAIVNGN
                     FNQVADACEAIGNWISDNNYDVDGPMFNIYHVSPGNDSNPDNWVTEVCFPVKKK"
     gene            4293..4874
                     /locus_tag="KNP36_003206"
     CDS             4293..4874
                     /locus_tag="KNP36_003206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0875055.1"
                     /translation="MKSNDKDARERIIEVTLNLLNEVDDIEEITVRKIAERANVGVGL
                     INYHFKTKDNLLSTAIGDVMSNIIAELYDDSVYTLRPIEDLKNLLKKLCDTGLHYEKV
                     LPFVLNQCITNGDMQAELDIVPMLRKIFGNKKDEMSLRIIALQIILPIQISALSTESF
                     QLYSGINIKNKYERDKFIDILIENIIGEDVDVR"
     gene            4871..5059
                     /locus_tag="KNP36_003207"
     CDS             4871..5059
                     /locus_tag="KNP36_003207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418249.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875056.1"
                     /translation="MKIITIGSSLITVLLFLSTMICGFWIKNNKVTDASSIKFHMNSA
                     IFTGIFLLISTILLIIYI"
     gene            complement(5229..6971)
                     /locus_tag="KNP36_003208"
     CDS             complement(5229..6971)
                     /locus_tag="KNP36_003208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloendopeptidase"
                     /protein_id="HBF0875057.1"
                     /translation="MVKSKKKIFVFLILIAVFIIFASYIRNYTNDTKKDSVRGTIPFE
                     KMEYKRPNIQSICENINKCNDKLLTAKTAKEQLNLFNEVDKIYQDFYSTLTIAKIRNN
                     IDSSDEFYSKEYKYLMSKSVDVDMSYKDFQDRFVTSKFSKELEKELGKDTFNYLKNIG
                     KLNSKEVEGLLKKEQDLVVKYEDLLAKSTVSIDGIEVDFEEALSRPNLSPEEYVKIYS
                     DYLKKYNPIFGNIFLELIQTRTEIASKQGFKNYIDYAYMNLNKDYSQEEAKKFRQDVK
                     DYIVPLYREISSKPSDSSIYIKVYKNRSFRKFDKVLEDISPKLKESFDYMKKYDLYDY
                     SSGKNKSPGGYTTYINKYKAPFLFNTWDNSFLGVTSFAHEFGHFYNYYNSINLNNKMQ
                     PSIDVCEVHSTSLEILFYKYFDDFFGKQSEAIKKEHLSIVLNTIIDACLYDEFQEIIY
                     KNPYMSLNDINKLFFDLEEEYGVSNNILREKNAPFWILVSHNFQVPFYYLSYGLASDV
                     SLQIWQLSQEDYRKAVDVYMDFLNQNTDAGFKDVVEKVNLQLPFQDGNLEEISSTLYD
                     YFGIDNPLELKNAS"
     gene            7400..8776
                     /locus_tag="KNP36_003209"
     CDS             7400..8776
                     /locus_tag="KNP36_003209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk family potassium uptake protein"
                     /protein_id="HBF0875058.1"
                     /translation="MKTIVRRLILYADGMRPTQIMVSGFAAIIVIGALLLTLPIASQS
                     GESIGLLNALFTATSAVCVTGLVMVDTATYWSLFGQIVIITLIQIGGLGFMTVATMFS
                     LMARKKIQLRERLLIQESLNQADLSGLVRLTRFVLIITITIEGIGALVLSTVFIPQFG
                     LSKGIWYSVFHAISAFCNAGFDLMGSVSGPFTSLNSYVNNFTVSMTVCALIVLGGLGF
                     PVVLDIVRKRRFSKLNVHSKVVLFSTATLIFVGALFIFLIEFNQKATMADLPLKGKVL
                     SAIFQSVTARTAGFNTLDLATLRESSVFVMIILMFIGASPASTGGGIKTTTLAVLIIT
                     VRSFLSGKSDIEAFERRLAPSTIKKSLGIFVISISAVIFGTLIISITQPNFTLVQSAF
                     EVTSALATVGSSLAGTPNLNALGKIIIIIFMFMGRVGSLTLFMAILSGGRRKSQPIRY
                     AEGKIMVG"
     gene            9087..9758
                     /locus_tag="KNP36_003210"
     CDS             9087..9758
                     /locus_tag="KNP36_003210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418257.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HBF0875059.1"
                     /translation="MKQYIVIGCGRFGSSVASTMHLLGHQVMAIDKNEDSVQSISDKV
                     THSLIVDVTDEQALRSLGLGNFDVAVVAIGSDIRASIMATLIAKEMGVELIICKAKDE
                     LQAKVLYKIGADRVVFPERDMGVRVAHNLVSDNILDHIELDPEYSIVEIVTPNSWVGK
                     TLIELELRARYEITVLAIKTGKNINVTPSPDEELTAGSILVIIGQNTSITAITSGNKG
                     IIRRR"
     gene            9947..10744
                     /locus_tag="KNP36_003211"
     CDS             9947..10744
                     /locus_tag="KNP36_003211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HBF0875060.1"
                     /translation="MITNINSKDNEKLKYTRALLKSKNRNKESKFIIEGYRIVMLALE
                     CMANLDYVFINEEFENKKEHVKLLEDLDKKNTKIYKTTNKNFKELVDTENTQGIIGVV
                     SFKKKKLSESINKKDKFVLILDRIQDPGNMGTIIRTADSAGVDAIIALKGCVDIYNPK
                     VIRSTMGSIFDMNIIDASQDETVDMLKSLDFNIVSSYLNTENFYDKIDYGSKVALVIG
                     NEANGINEELVSKSDILVKIPIYGKAESLNAAISSAILMYEIKKYLI"
BASE COUNT         4044 a         1317 c         1607 g         3893 t
ORIGIN      
        1 taattaacac tactttttta aatataatca atattgattc tacaatatta ttaatactac
       61 tttttacaat ataatcaata ctgattctac aatataatta acactacttt ttaaatataa
      121 tcaatatcga ttctataata ttaacactac tttttataat ataataaata ctgattctat
      181 aatataatta acactacttt ttaaatataa tcaataccga ttctataata ttaacactat
      241 tttttatgct atataacaat tattgaaaat gatataaata taatatctca aataatatga
      301 atataacatc tgaatagagg gtgttttatt tgtaaaaaat aagtttacag tttgagcgta
      361 taaacttatg gtaaaggaga ataattatga gttataagaa gattgcaatt ataacgggtg
      421 ctaatagtgg ttttggtaaa gagtttctaa agttattaat aaatgaagaa gaaataacag
      481 aaatatgggc agttgcaaga aacaaggcga gattaaatca attagtagat gaatttggaa
      541 gtaaggtaaa aattttttca aaagatttat caaaaataga agaagtaaaa gaaattggta
      601 catttttaag taaagaaaat gtatgtataa aataccttat aaacaatgct ggttttgcaa
      661 aattctgttc atacaatgat ttaagtatag atgaatctat taatatgatt gatttaaata
      721 ttagtgctgt tgtagcattg ggacttatat gtattccata tatgcaaaag ggaagccata
      781 tcatgaatat ttcttcacaa gcatcattcc agccattgcc atatcaaaat atttatagtt
      841 caactaaagc gtttataaga aattatacaa gagcattaaa tgttgaactt aagagtaaag
      901 ggataaatgc aattgctgta tgtccaggtt ggatgagtac aaatctattt aagagaggta
      961 tagttgtagc tgaaaaaggg acaaaaaatt tcccaggcat agtgtctcca gacgttgttg
     1021 ccaaaaaagc attgaaggat gcaaagaaaa ataaggatat ttctgtgtat ggtataaata
     1081 caaaatccag tcatttatta gcaaaactat tgccacaaaa aatgatgatg aaggtttggt
     1141 taatgcaaca acatattaag gaataagagt tttggtaatt aagtatcagt tggagattca
     1201 atctgttata tattatgaga agttttgttg agcaaataat aattgtgaca aaacggctta
     1261 tctagtgacg ataagccgtc tataatgtat ataaaatata tttttgattt tactttattt
     1321 agatattgaa gtattaaaat atgtaggact tgaaatttta taaagataaa tactatgata
     1381 ttttgtaaaa actgcgatat gttgatatca catagtttga ctatactgtt aaattgaagt
     1441 tttcttattt tgcattatgc ttattactta atgatttaga ctataatttc cataccatca
     1501 tatgcaaaat aaatgttatc aagtttcttt tctaattcac tgtaataacc atatgatttt
     1561 ccccacattt cgtcaatatg tgtaacaata atttttttaa ttctataata gtttttaatt
     1621 tcaacaatct catctaaagt aaatatttca tctttaaatg gtgtgtcttt aagttttgta
     1681 ccatcattta atataccatc atcagaaact agacttatta ttaaaatatc agcatcaaag
     1741 tacatatcac tatgagtaaa tggcttggga ttacagcagg catatatgac ttttttttca
     1801 ttctctttga taacatagaa ggttatattc ctgtctgggt tattgttaat caaatcaata
     1861 tcaaaattat ttatctttac atgcgaagtt tcattaatag aaatgcaatt tataacatca
     1921 ccataatatt taagacaatc gagattcgtt cggtttatat cttcaattac ttcaggaagc
     1981 gcataaaagc caattggatt attttctcct gtgataaagt cacatcctat tttttcgaca
     2041 attctaatac ccttaacatg gtctgggtca tggtgagaaa ttgaaatatg ttttacttcc
     2101 gatatttttt gtctgttaca agctactgca atgtcttcag gtgtgtctat cagcattttt
     2161 atatcatcaa tatataaact tggtcctaat cgttcatatc ttccgccttt ttgcctggct
     2221 tcttcacata ttttgcattt acaaaatgaa cttggaataa ttgacatacc gccactacca
     2281 acaattttta atttcaaagt tattacacca ccttctaaaa atattagatt atataaataa
     2341 tatacaagca caactgatta acaaaattat gagttaataa attatatcac atgtaaatat
     2401 gaaagaatag tatgaaattt ttataaacat atattaaatg tttctcaatg aaattgactt
     2461 tgtatatgaa ctgaatgact tattcaatat ggataagaca tttttcttgt aataagatat
     2521 gattgtccta taaggtttat gtaattttga tataatttga tataatatat tgattaacaa
     2581 catacatgtt attggtgagc atatttctat agaatggaat atataatttt ttatatttat
     2641 cattgtatta ttgtacaaag aaagttaaaa agagtagagt acaaaggaat tatttgtact
     2701 ttactctttt attgttttgt taaaaaaact aatttatatt agtgattaaa atatatttaa
     2761 ctagagtata aggatagtat ataatcttat aattgattta tctgacaaat taagataata
     2821 tcctaatcaa attctagtca tttaaacata aaatcataat tgatttatct gacaaattga
     2881 gataatatcc taattaaatt gtaggtattt aaacataaca ttataaataa tttatctgac
     2941 aaattaagat aatatcctaa tcaaattcta gtcatttaaa cacaacatca caattgattt
     3001 atctgacaaa ttaagataat atcccaatca aattctagtc atttaaacat aacatcacaa
     3061 gtgatttatc tgacaaatta agataatatc ctgattaaat tctagtcatt caaacataac
     3121 atcacaagtg atttatctga caaattaaga taatatccta attaaattgt agatatttat
     3181 acataacact aaaagtaatt tgtttaacaa attaagataa tatcctaatt aaattgtagg
     3241 tatttataca taacactaaa agtaatttgt ctaacaaatt aaaatattat ccaattaata
     3301 taaaaattac ttctttttaa ctgggaagca tacctctgtt acccaattat caggattact
     3361 atcgttgcca ggacttacat gataaatatt aaacatagga ccatccacat catagttatt
     3421 atctgatatc caattaccaa tagcctcaca agcgtctgca acttgattga aatttccatt
     3481 aacaattgca gttgcagcag tcacacttgg aacagtctta aatttaacat gttcagtatc
     3541 tttatacttt ccagatacag caacttgtac ttcaacatct acataatctt ctttatatcc
     3601 agtatcataa aaaactgctt tagaatactt tgggggttca atttgaacat tctggtcttt
     3661 tgtctctaaa aatgcttgat gccataacat tccttcgtct tgataagttg gtataaccct
     3721 tctaagtgtc atcatatatt ttggtgcaaa attctttata gttacatcat aatttttcat
     3781 aatatcattt cctccaattc ttttaatagt ggtttctatt tttaatagtt ttttctgtgt
     3841 atcttctaat tgttctttta cttgagaatg gtggatattt agatatttta tgagactttc
     3901 tttatcgtta tattctgtca aaatttcttt tatagaatac aagccaaagc ccatatcttt
     3961 tagtgcatgg attctgtttg tagtagaaag ttggtctgca ctatagtatc tatatccatt
     4021 agttttattc gtatgagaag gagttaaaag tcctatttca tcataatgac gtaacatacg
     4081 aatactaatt ttacttagct ttgaaaaatc gcctatctta aacatgtttt tgtctccttt
     4141 ataaaggtac ttttagctta atattaatat aaaccatatc ataatgttag agtcaactaa
     4201 aattataatt aaattatatt gacatatgat gaaaaaaata ttatactgaa catgttcaga
     4261 actgaaaatg ttaattgttt tggaggtcta ttatgaaaag taatgataaa gatgctagag
     4321 aacgtataat tgaagttaca ttgaatcttt taaatgaagt agatgatatt gaggagatta
     4381 cagttagaaa aattgctgag cgtgcaaatg ttggagttgg tttaataaat tatcatttta
     4441 aaacaaagga taatttgttg agtactgcca taggagatgt gatgtcaaat ataatagcag
     4501 agctatatga cgatagtgta tatactctaa gacctattga agatttaaaa aatttattaa
     4561 aaaaattgtg tgatactgga ttacattatg aaaaagtgct tccttttgta ttgaatcaat
     4621 gtataaccaa tggagatatg caagcagaac ttgatattgt ccctatgctt cgtaaaattt
     4681 ttggaaataa aaaagatgaa atgagtctaa gaattattgc cctgcaaatt attttaccaa
     4741 tacagatttc tgctttatct acagaatcat ttcagttata cagtggtata aatataaaga
     4801 ataaatatga gcgagataaa ttcattgata ttttaataga aaatattatt ggagaggatg
     4861 ttgatgtaag atgaaaatta taactattgg ttcaagtctt atcactgttt tactttttct
     4921 ttcaactatg atttgtgggt tctggattaa gaataataag gtaacagatg caagttctat
     4981 taagttccat atgaatagtg ctatttttac agggatattt ttattgattt ccacaatcct
     5041 tttaattata tatatataaa aataataata ttattaataa ataaagtatc agaaattata
     5101 aagacaagag tcttaaaaat ttctgatact ttaccatata attttattaa acattaattg
     5161 tgtgtgaaaa aatatcactt atttcaatct aatactaaat cttaagagtg agtataaagt
     5221 attagaaatt aagaagcatt ttttagttca agcggattat ctataccaaa ataatcatat
     5281 aaagtagagc ttatttcctc taaatttcca tcttggaaag gtaattgtaa atttaccttt
     5341 tctaccacat ctttaaatcc agcatcagta ttttgattta aaaaatccat atatacatca
     5401 acagcttttc tgtaatcttc ttgtgataat tgccatatct gaagtgatac atcagatgca
     5461 agaccataac tcaagtaata aaaaggaact tggaagttat gagatacaag tatccaaaaa
     5521 ggagcatttt tttctctaag tatattattg gaaactccat attcttcctc taaatcaaaa
     5581 aacaatttat tgatatcatt tagactcata tatggattct tgtatataat ttcttgaaat
     5641 tcatcataaa gacaagcatc aataatagta tttaaaacaa tcgataagtg ttcttttttt
     5701 atagcttcag attgtttacc aaaaaaatca tcaaaatatt tataaaatag aatttctaaa
     5761 gatgttgaat gaacttcaca tacatctata cttggttgca tcttattgtt taagttaata
     5821 ctgttgtagt aattataaaa atgaccaaac tcatgagcaa aactagtaac acctaaaaaa
     5881 gaattatccc atgtattaaa caagaaaggt gctttatatt tatttatata agtagtatat
     5941 cctccaggtg atttgttttt tccagaagaa taatcgtaca agtcatattt tttcatatag
     6001 tcgaagctct cttttagttt tggagatata tcttcaagta ctttatcaaa cttcctaaat
     6061 gagcgatttt tatatacttt aatataaata gaagaatcag atggtttaga tgaaatctct
     6121 ctatataatg gaactatgta atcttttaca tcttgtctaa attttttagc ttcttcttga
     6181 gaatagtctt tgtttaggtt catataggca taatctatat aattcttaaa tccttgctta
     6241 cttgctattt cagttcttgt ctgtataagt tctaagaata tgttaccaaa tataggattg
     6301 tattttttta agtaatctga ataaattttc acatattctt cagggctaag atttggtctt
     6361 gacaaggctt cttcaaagtc tacctctata ccatctattg atactgtaga tttagctaat
     6421 aagtcttcat attttacaac taggtcttgc tcttttttaa gcaaaccttc aacttcttta
     6481 gaattaagtt ttccaatgtt ctttagataa ttaaatgtat cctttccaag ttctttttct
     6541 aattctttag agaatttaga agttacaaat ctatcttgaa agtctttgta tgacatgtca
     6601 acatctactg atttactcat aagatactta tattccttag agtaaaattc gtctgatgaa
     6661 tctatgttat ttctaatttt tgctatagta agtgtactgt aaaaatcttg ataaatttta
     6721 tcaacttcat taaataaatt taattgttcc ttagctgttt tagctgttaa aagtttgtcg
     6781 ttgcacttgt taatgttttc gcaaattgac tgtatattag gacgcttata ttccattttt
     6841 tcaaaaggaa tagttcctct aacagaatct ttttttgtat cattagtata atttcttatg
     6901 tatgatgcaa atataataaa aactgcaatt aaaattagaa aaacaaatat tttcttcttg
     6961 gatttaacca taaaaatcct ccaatcatgg atatagttat taattatttt actatattaa
     7021 atataaaaaa tgcatgttaa gaaaatttaa cataaagata tagataagat tataaataat
     7081 ataaaaaatt taacttcaaa aaagtatatg aaatttatac tggtaaaatg ataaataaat
     7141 tttaagtaca aaatagtaaa agctatgata gttttagacc tattatatgt aaaaaatata
     7201 gatgtttttg gtgcaattta aattaaaaga tatatataaa aatttaaaat attccaaaca
     7261 gaaattataa aaattactat cattgtcttt atacaatatt tatactataa tagaataata
     7321 atttagagga aagctctaaa aataaacaaa ttaagggtct taacagtagt gattttatgt
     7381 taaggaggta taaagaaagt tgaaaacaat agttagaaga cttattctct acgcagatgg
     7441 aatgcgtcct actcaaataa tggtatctgg gtttgctgcg attattgtaa tcggagcatt
     7501 gttgttaaca ctcccgatag cgtcgcagag tggagagagt ataggcttat taaatgctct
     7561 atttacggct acttcagcgg tttgtgttac tggtctagtt atggtagata cagcaactta
     7621 ttggagttta tttggacaga tagttataat aacattgata caaattggtg gtcttggatt
     7681 tatgaccgta gccacaatgt tttcacttat ggcacgaaaa aaaatacaac taagagaaag
     7741 attattaata caagagtcat taaatcaagc tgatttatcg ggacttgtaa gacttacaag
     7801 atttgtatta ataataacca taacaataga gggaataggt gcactggttt tatcaactgt
     7861 ctttattcca caatttggtt tgtctaaagg gatatggtat agtgtatttc acgcaatatc
     7921 agcgttttgt aatgccggat ttgacttgat gggcagtgta agtggcccat ttacatcgtt
     7981 aaattcttat gtaaacaact ttacagtatc aatgactgtt tgcgcactta tagtgcttgg
     8041 agggctagga ttccctgttg tacttgatat tgtaagaaaa agaagatttt caaaattaaa
     8101 tgtgcattct aaggttgtat tgttttcaac tgctacactt atttttgtgg gtgcattatt
     8161 tatttttctt atagaattta atcaaaaagc tactatggcg gacttgcctt taaagggaaa
     8221 agtactatca gcaatatttc aatcagtaac agcaagaact gctggtttta atacgcttga
     8281 tttagctact ttacgagaaa gtagtgtatt tgtaatgata attttgatgt ttattggagc
     8341 atcacctgca tcaactggtg ggggtataaa aacaacaaca ctagctgttt taatcattac
     8401 agttagaagt tttctatcag gaaaatcaga tatagaagct tttgaaagaa gattagctcc
     8461 atcaactata aaaaaatctc ttggtatatt tgtaatcagt atatcagcag ttatttttgg
     8521 aacattgatt atttcaataa ctcagcctaa ttttacatta gttcaatcag cttttgaggt
     8581 tacatcagca cttgctacag ttggttcaag tttagctgga actccaaact taaatgcttt
     8641 aggtaagatt ataataataa tctttatgtt tatgggtaga gttggttctc ttactttatt
     8701 tatggctata ctttctggtg gtagaagaaa gagtcaacca atcagatatg cagaaggtaa
     8761 aattatggtt ggttaagtta ccaaggagta gtataaattt ataatgggtt tagagtagca
     8821 ctgtaaatct gttgataaaa taaatgagcc tagatgtaat tatatgaaga aataaaatca
     8881 actaatgaac aaaattaatt aatgaaataa aaaaacaggg aaataaaata caaataaaaa
     8941 ggtaaatcaa aattaaatta atctgtgtgt ataaaattat atattgtgta taagttttgt
     9001 atgtgtaaag tatataagtt ttgtatgtgt aaacaattaa tttaagagat attatataaa
     9061 ttgtgtatta gggaggaagt ttcgagatga agcaatatat agtcattggg tgtgggagat
     9121 ttggaagttc agttgcgtct actatgcatc ttttaggaca tcaagtaatg gcaatagaca
     9181 aaaatgaaga ttcagttcaa agtatatctg acaaggtaac ccattcactt atagtggatg
     9241 ttactgatga gcaagcgtta aggtcattag gtttaggtaa ctttgatgta gcagtagttg
     9301 caataggttc tgatataagg gcatctataa tggcgactct tatagccaaa gaaatgggtg
     9361 tagagttgat aatatgtaag gcaaaggatg aattacaagc taaagttctt tataaaattg
     9421 gtgcagatag agttgtattt ccagaaagag atatgggagt aagagttgca cacaatttag
     9481 tttcggataa tatattagac catattgaac ttgacccaga gtattcaatt gttgaaatcg
     9541 taactccaaa tagttgggtt ggcaagacac ttatagagct tgaattaaga gctagatatg
     9601 agataactgt acttgctata aaaacaggta aaaatataaa tgttacacct tctccagatg
     9661 aggaacttac agccggaagt atcctagtta taatcggtca aaatactagt ataacagcga
     9721 taacatctgg aaataagggg ataattagaa gaagataatt tactatttaa tatatattta
     9781 attgcaatga aagcagatag tatcatataa ttatgaatag ttatatgata ctattttttt
     9841 aatcgaaggt agtatttatt tgtaagatta gataaagaga agttaaatta aaagtaagga
     9901 ggctgtgcta atataaaaat ttataagtta ttagcattta gataaaatga ttacaaatat
     9961 aaacagtaag gataatgaaa agttaaagta tacaagagca ctattaaaat caaagaatag
    10021 gaataaagag tcaaagttca taatagaagg atacagaata gtaatgcttg cacttgaatg
    10081 tatggcaaac cttgattatg tatttatcaa tgaagaattt gaaaataaga aagaacatgt
    10141 aaaactatta gaagatttgg ataaaaaaaa cacaaagata tacaagacta ctaataaaaa
    10201 ctttaaagaa ttagtggata cagaaaatac tcaaggaata ataggtgtag tttcatttaa
    10261 gaaaaaaaaa ttaagtgaaa gtataaataa aaaagataaa tttgtattga ttttagacag
    10321 aatacaagac ccaggaaata tggggactat aataaggact gctgattctg ctggagtaga
    10381 tgccataata gcactaaagg gatgtgtcga tatatacaac ccaaaagtaa ttaggtctac
    10441 tatgggttct atttttgata tgaatataat tgatgcttca caagatgaaa ctgtggacat
    10501 gcttaaatca ttggatttta atatagtttc aagttactta aatacagaaa atttttatga
    10561 caaaatagat tatggctcaa aagtagcatt ggtgatagga aacgaagcaa atggaataaa
    10621 tgaagaactt gtatcaaagt ctgatatttt ggttaagata cctatatatg gtaaagccga
    10681 gtcgttaaat gctgcgataa gctctgctat actgatgtat gaaataaaaa aatacttaat
    10741 ttaatgtatt gtaataaata taatgtcatg ttataatctt gaattaaata gtagagtatc
    10801 aaaaatagtc aatatatatt aaaaaaataa ttaaattaat tatatattag atgtatatta
    10861 t
//
LOCUS       DAEHWM010000110        10793 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.113, whole genome shotgun sequence.
ACCESSION   DAEHWM010000110 DAEHWM010000000
VERSION     DAEHWM010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10793)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10793)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10793
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.113"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            292..750
                     /locus_tag="KNP36_003212"
     CDS             292..750
                     /locus_tag="KNP36_003212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0875061.1"
                     /translation="MEFINFVSDKVIDLKMDCKTKEDFFKEIHNKVFDLGFVKEEFGE
                     KILARENVFPTGLNLGDYGVAIPHTDAEYIKEQFISVCTFNEPVVFSSMEDQDEKVPV
                     NLAFVLGLNQPHSQLSVLTELMGIMQNKELVDKLMSSTDKEEVLKTLKSL"
     gene            811..1086
                     /locus_tag="KNP36_003213"
     CDS             811..1086
                     /locus_tag="KNP36_003213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0875062.1"
                     /translation="MKKILVACGAGIATSTVVCDKVERLVKENNIQAEVIQCKIAECA
                     TKQEGADLIVSTTILPTTYNIPAIKATAYITGVNTAALDKKILDALK"
     gene            1145..2419
                     /locus_tag="KNP36_003214"
     CDS             1145..2419
                     /locus_tag="KNP36_003214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012951111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HBF0875063.1"
                     /translation="MDKLLAVVQYILNMGPTVILPITIVVLGMIFRIKFTKALKSGLT
                     IGIGFVGINLVVNLLTSTLGPAAQGMVERFGLNLTVIDVGWPTTASATWASPVAPILI
                     PVCLLVNLLLLYFNKTKILNVDIWNYWHFIVAGAVGYIVTGSYVWAIFCAILMELLVL
                     FIAEKTAKNVQEFYDLEGIALPTGSTASFAPLGYLVGKFVEKIPGINKIQADPDSIQK
                     RFGIFGEPMMMGIILGIILGALAGYDVAGIFNVGISMGAVMLLMPRMVRILMEGLIPI
                     SESIRDFLQAKYGDRELYIGLDAAVATGHPAVISTALILVPITLFLAVILPGNKVLPF
                     GDLATIPFYMAFIVCFRKGNIVQSVITGTIVIAISLYMATNFADVHTQLLQQANMMPE
                     GTTMVTSIDTGGNLLKWGILKLSQLVSSFGIF"
     gene            2549..3601
                     /locus_tag="KNP36_003215"
     CDS             2549..3601
                     /locus_tag="KNP36_003215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBF0875064.1"
                     /translation="MKAAVLHGTNDMRFEDIEIKPCESDEVKIKVMAAGICGSDPPRV
                     LKHWKYPVPAIPGHEFSGVIAEVGKDVKNVKVGDRVVAIPFIPCNECEYCKRGLFSLC
                     DDHGMLGAKSFGAFAEYVNIKATNVLPIGDMNFEDAAMIEPLAVAMHGVLNIGVQVGD
                     TVAVMGSGTMGQLVIQGLKIAGAGTIIAVDISDNKLRESKELGADIIINAKDINPVEK
                     IKELTGGKGVDIALECAGSKITQEQCLLITKKKSKIGFLGIAYSDITLSEEAFENIFR
                     KELELKGFWNSYSAPFPGQEWTKGINLVNEGKIKLKEMVSHRFSLEDTYKAFEMIRDR
                     KEEFNKILILPQGVEK"
     gene            3601..4632
                     /locus_tag="KNP36_003216"
     CDS             3601..4632
                     /locus_tag="KNP36_003216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012986518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding dehydrogenase"
                     /protein_id="HBF0875065.1"
                     /translation="MKAVVKTKPGYDNVEVLEVEEPKATGDKVKIKVEYSGICGSDIH
                     SFKGEYANIKAPVTLGHEFSGIVVEVGEDVKNIKVGDRVTSETTFATCEKCIYCETKD
                     YNLCPTRKGIGTQVNGSFAEYVLSREESIHVLPENVSLLSAALTEPLACCVHAALEKT
                     TIESSDTVLIIGPGPIGLLLAQVVKSQGATVIMSGVTKDKERLEIAKNLGVDRTVNVM
                     EESLADVVNEMTDGNGVNKGFDCSGFMPAVNEALRLLRKKGTFVQVGIFAKKLNEMDQ
                     EAIIQRELQYIGSRSQKPSSWITALDLMANGKVNTEALVTRTVGLDEFKEGITALMNG
                     EEIKVAVKS"
     gene            4724..5536
                     /locus_tag="KNP36_003217"
     CDS             4724..5536
                     /locus_tag="KNP36_003217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HBF0875066.1"
                     /translation="MSTLRDHSNNIRKNIIKMVAEAKSGHPGGSLSIADMLTVLYFDK
                     MNVCAENPKMADRDRFVLSKGHAAPALYATLAEKGFFPEEELITLRKFGSKLQGHPDM
                     KKVAGIDMSTGSLGQGLSAANGMALAGKLDNKDYTVYTILGDGEIQEGQIWEAAMTAS
                     HYKLDNLIAFVDLNGLQIDGSNEEVMNVSPVDDKFKSFGWNVIVINGHSFEEIGNAVD
                     EAKKVTGKPTVIIAKTVKGKGVSFMENNAAWHGTAPNAEQAEQALKDLEGGL"
     gene            5539..6459
                     /locus_tag="KNP36_003218"
     CDS             5539..6459
                     /locus_tag="KNP36_003218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HBF0875067.1"
                     /translation="MGIATREAYGQVLKELAENKDIVVLDADLGKATKSISFKEVAPD
                     RFFDMGIAEGDMIGTAAGLATCGKIPFASTFAIFAAGRGYEQIRNSVAYPNLNVKIAA
                     THAGVTVGEDGGSHQAIEDISLMRGIPNMVVLNPADALEARQAILTSIDYNGPVYIRL
                     GRAATPDVNSENYKFEIGKGTVLREGSDITVIATGIMVAKALEAAEELAKEGINVEVV
                     NISTIKPLDEALIKETAKKTGKVVTAEEHSIIGGLGSAVCEALAETKDVVVRRIGVKD
                     VFGQSGTPADLLKHYGLTTEDIVKNIKELL"
     gene            6634..7080
                     /gene="rpiB"
                     /locus_tag="KNP36_003219"
     CDS             6634..7080
                     /gene="rpiB"
                     /locus_tag="KNP36_003219"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 5-phosphate isomerase B"
                     /protein_id="HBF0875068.1"
                     /translation="MKISIGCDHGGYELKEYIKENLINKGIEVEDVGTNSKESVDFPI
                     YAKKVSQNVQSKKSDLGILCCGTGIGMSIAANKFKGIRAAVVSDCFSAKATREHNNTN
                     VLCLGERVIGKGLAMRIVEEWLNSSYNGERHARRLQMIDDIEKENL"
     gene            7110..7775
                     /locus_tag="KNP36_003220"
     CDS             7110..7775
                     /locus_tag="KNP36_003220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HBF0875069.1"
                     /translation="MSIICASIMCADQMKLKEELEALEEAGVKLLHCDVMDGIFVKNL
                     AMGPELLKSISENTTIPLDIHLATETPDKYIDMMSYIKPKYISFHVESSTNVKADIQK
                     LRNYGIGPVLAISPQTSVDKIEEYISLVEGILVMTVNPGFAGQKFNLSVLDKLDKLTE
                     ILKDYDNPPFIEVDGNINKDTIKLMNGKKVDIYVVGTSALFNDKPPISYKDKIEELKE
                     SIK"
     gene            7885..9387
                     /locus_tag="KNP36_003221"
     CDS             7885..9387
                     /locus_tag="KNP36_003221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomannomutase/phosphoglucomutase"
                     /protein_id="HBF0875070.1"
                     /translation="MGDLYKLQNGTDIRGIAYENDSKEVNLTVEEVKKIAKAFHIWLK
                     EKTKKDKVTVAIGTDSRITGSQFRSTVIETLTNDDCNVIDCEIATTPAMFMTTIMDGY
                     NSDGAIMITASHLPYYYNGLKFFTESGGLEKTDIKEMLDIAVKNDSVDYEEVNKKGEV
                     IVKNLIEDYSNLLIDKIRKGVNSSKNYEKPFSGLKILVDAGNGAGGFFAEKVLHILGA
                     DTTGSQFLNPDGMFPNHIPNPENKEAMESICKAVLDNKSDLGIIFDTDVDRAAIVGKN
                     GKPINKNALIAVISSIVLEEHPKTAIVTDSITSEGLAKFINELQGRHHRFKRGYKNVI
                     NEAIRLNSEGEECHLAIETSGHAALKENYFLDDGAYLIAKILIKVAKLSLEGKTIEEL
                     IENLEEAQEEKEVRIGINKEDFRPYAEDILKDLDSHVKSIDGWSVAPNNFEGIRVNCD
                     ESNGDGWFLLRISLHEPLLALNIESNKIGGAEQIYSKLKLFLEKYDLKGL"
     gene            complement(9699..>10793)
                     /locus_tag="KNP36_003222"
     CDS             complement(9699..>10793)
                     /locus_tag="KNP36_003222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0875071.1"
                     /translation="NYNLKDMSITYVFFSNLLNMYNKKTINKKLAIVFLISIVVQAII
                     QYLVLIFFMYIYYAEAIAIVILFTLVNTVFHFYIYNFLSVKFNYINNISKNIKNIENG
                     NLKYKLEVIGDDEISTLAKSINNITGGLETAVDANIKNERMKAELITNVSHDLKTPLT
                     SILSYVDMLKNNDFDRETINDYINILDKKSQRLKLLIDDIFEASKLSSGDVEFNITKT
                     DIRELLIQSIVEFEDKIQNSSLDFIIETPEYAVFTMIDGKKTWRVFENLICNILKYSM
                     PNTRVYIDMFIKEENIILTFKNISNDKLNLKPEELIERFRRGDISRKTDGSGLGLSIA
                     QNIIELENAHMEIIIDADLFKVMLTFRRVN"
BASE COUNT         4306 a         1224 c         1977 g         3286 t
ORIGIN      
        1 ttaaacataa aaaaccattt gtaaaaaaca aaaaaatcat ttctctaaca aaaaaaacca
       61 caaaaaatat aaaaaagtat ggctagttaa gtgattaaca agtaaaaatt aaaataaaaa
      121 tcaaaaaaaa tttatcaatg aaagtcagct aaaatcctgg aagagagcat tatttttggg
      181 aaaacatttt cttttgtttc acaaaaaaag ccactttttg gcacacaaca tgctttatat
      241 aaagtcaaga aaaactaagg tataagacaa aggcaattag gaggtgtaaa tatggagttt
      301 ataaattttg taagtgataa agttatagac cttaaaatgg attgtaaaac gaaagaagat
      361 ttctttaaag aaatacataa taaagttttt gatttaggct ttgtaaaaga agaatttgga
      421 gaaaaaatat tagcaagaga aaatgtattt ccaacaggtt taaatttagg tgattatgga
      481 gtagcaatac cacatacaga tgcggaatat attaaagagc aatttatatc agtctgtact
      541 tttaatgaac cagtagtatt tagttctatg gaagaccaag atgaaaaagt acctgtaaat
      601 ttggctttcg tattaggact taatcaacca cacagtcaat tatctgtatt aacagaatta
      661 atgggaatta tgcaaaataa agagttagtt gataagttga tgagttctac tgataaagaa
      721 gaagttttaa agacactaaa gtctttataa aaataaaaaa gtactaaaaa taaaaaatat
      781 aaaaataaaa attattagga ggaaataaaa atgaaaaaaa tattagtagc atgtggagca
      841 ggaatagcaa catcaacagt agtttgtgac aaggtagaga gattagttaa ggaaaataat
      901 atacaagcag aagttataca atgcaaaata gctgaatgtg caacaaagca agaaggagca
      961 gatttaatag tatcaacaac tatactacca acaacttata atataccagc aataaaagca
     1021 acagcatata taactggagt aaatacagca gcattagata aaaaaatatt agatgcttta
     1081 aaataatcct atcatagata cattgaaata atattttata aaacagaaaa aggaggattt
     1141 ataaatggat aaattattag cagtagtaca atacatttta aatatgggac cgacagtaat
     1201 actaccaata acaattgtag tactaggaat gatatttaga attaagttta caaaagcttt
     1261 aaagtcaggt cttacaattg gtataggatt tgtgggtata aacttagttg taaacctatt
     1321 aacatcaaca ctagggccag cggctcaagg aatggttgaa agattcggac ttaatttaac
     1381 agtaatagat gttggttggc caacaacagc atcagcaaca tgggcttcac cagttgcacc
     1441 aatattaata ccagtttgtt tattagtaaa cttactatta ttatacttca ataaaacaaa
     1501 gatattaaac gttgatatat ggaattattg gcactttata gtagcaggtg cagttggata
     1561 tatagtaaca ggaagttatg tttgggctat attctgtgca atactaatgg agttattagt
     1621 actgtttatt gcagaaaaga cagcaaaaaa tgttcaggag ttttatgatt tagaaggtat
     1681 agcattacca actggttcaa cagcttcatt tgctccactt ggatatttag taggtaaatt
     1741 tgttgaaaaa ataccaggaa taaataaaat acaagcagac ccagactcta tacaaaaaag
     1801 atttggtata tttggagaac caatgatgat ggggattata ctaggtataa tacttggagc
     1861 acttgcggga tatgatgtag caggaatatt caatgtaggt atatcaatgg gtgcagtaat
     1921 gttacttatg cctagaatgg ttagaatatt aatggaaggt ttaattccaa tttcagaatc
     1981 aataagagat ttcttacaag caaaatatgg agacagagaa ctttatatag gtctggatgc
     2041 agcagtagca actggacatc cagcagttat atcaacagct cttatacttg ttcctataac
     2101 tttgttctta gcagttatac taccaggaaa caaagtttta ccatttggag acttagcgac
     2161 aataccattt tatatggcat ttatagtgtg ttttagaaaa ggtaatatag ttcaatcagt
     2221 tataacagga acaatagtaa tagctatatc actttatatg gctacaaact ttgcagatgt
     2281 tcatacacaa ttattacaac aagcaaatat gatgccagaa ggaacaacaa tggttacaag
     2341 tatagataca ggtggaaact tgctaaaatg gggaatattg aaattatctc aattagtttc
     2401 ttcatttgga atattctagt atgtagttaa tagagattac tcttttttag taaagtatgc
     2461 gaaaatttaa catttagcag ctactaaaaa agagtaatat tttttataaa tttttaaaaa
     2521 tacaaaatac aagaggagga gatttatcgt gaaagcagca gtattacatg gcacaaatga
     2581 tatgagattt gaagatatag aaataaaacc atgtgaaagt gatgaagtaa aaataaaagt
     2641 tatggcagca ggaatatgtg ggtcagatcc tccaagagta ttaaaacatt ggaaatatcc
     2701 agttccagct ataccaggac atgagttttc tggagtaatt gctgaagttg gtaaggatgt
     2761 aaaaaatgta aaagttggag atagagtagt tgcaattcct tttatacctt gtaatgaatg
     2821 tgaatattgt aaaagaggat tattttcatt gtgtgatgac catggaatgt taggagctaa
     2881 aagttttgga gcttttgcag agtatgtaaa tataaaagct acaaatgtac ttccaatagg
     2941 agatatgaac tttgaagatg ctgcaatgat agagccacta gcagttgcta tgcatggagt
     3001 acttaatata ggtgttcaag ttggagacac tgtagctgta atgggtagtg gaacaatggg
     3061 gcagttggta atacaaggac ttaaaatagc aggggcagga acaattatag cagttgatat
     3121 atctgataat aaattaagag aatcaaagga attaggggct gatataataa ttaatgctaa
     3181 agatattaac ccagtagaaa aaataaaaga acttactggt ggaaaaggtg ttgacatagc
     3241 tcttgaatgt gcaggttcaa aaataactca agaacaatgt ttacttataa ctaaaaagaa
     3301 aagtaagata ggatttttag ggatagcata ttcagatata actttatcag aagaagcatt
     3361 tgaaaatata tttagaaaag aactagaatt aaaaggtttt tggaactctt attctgcacc
     3421 atttccagga caagaatgga ctaagggaat caatctagtt aatgaaggaa agataaaatt
     3481 aaaagaaatg gtatctcata gattctcact tgaagatact tacaaagcat ttgaaatgat
     3541 aagagataga aaagaagaat ttaacaaaat attaatttta ccacaagggg ttgaaaaata
     3601 atgaaagcag tagttaaaac taaaccaggc tatgataatg tagaagtttt agaagtagaa
     3661 gaaccaaaag ctacaggaga caaggttaaa ataaaagtag aatatagtgg tatatgtggt
     3721 tcagatatac attcatttaa aggtgaatat gcaaatataa aagccccagt aacattaggt
     3781 catgaatttt ctggaattgt tgtagaagta ggagaagatg ttaaaaatat aaaagtagga
     3841 gatagagtta catcagagac tacttttgca acttgtgaga aatgtatata ttgtgaaact
     3901 aaagattata acttatgccc aactagaaaa ggtattggta ctcaagtaaa tggaagtttt
     3961 gctgagtatg tattatcaag agaagaaagc atacatgtac ttcctgaaaa tgtatcttta
     4021 ttatcagcag cccttacaga gccactagct tgttgtgttc atgcagctct tgaaaagact
     4081 actatagaaa gttctgatac agttttaata ataggaccag gaccaattgg tttattatta
     4141 gctcaagttg ttaaatctca aggtgctaca gttataatgt ctggtgttac aaaagataag
     4201 gaaagattag aaatagctaa aaatcttgga gtagatagaa ctgtaaatgt aatggaagaa
     4261 agtttggcag atgtagtgaa tgaaatgact gatggaaatg gagtaaacaa aggatttgat
     4321 tgttctgggt ttatgccagc agttaacgaa gccttaagac tgcttagaaa aaaaggtact
     4381 ttcgtacaag ttggaatctt tgctaaaaaa ttaaatgaaa tggaccaaga agcaataatc
     4441 caaagagagt tacaatatat aggaagcagg tctcaaaagc caagttcttg gattacagca
     4501 ttagatttaa tggcaaatgg gaaagtaaat acagaagctt tagttactag aactgttggt
     4561 ttagacgaat ttaaagaagg tattacagct ttaatgaacg gggaagaaat aaaagtagca
     4621 gtaaaatctt aaaaaaacat ttgtattatt ttaaaaaaaa ttgtaaaatc tactgtagga
     4681 taaaaaaatg taaggtctta aaaaataaca ggaggaagaa agtatgagca ctcttagaga
     4741 tcattctaat aatattagaa aaaacataat aaaaatggtt gcagaagcta aaagcggaca
     4801 tccaggtggt tcattatcaa tagctgatat gttgacagta ttatattttg ataagatgaa
     4861 cgtatgtgca gaaaatccaa aaatggctga tagagataga tttgttctat caaaaggtca
     4921 tgcagcacca gctttatatg ctacattagc agaaaaagga tttttcccag aagaagaatt
     4981 aataacacta agaaaatttg gttctaagtt acaaggtcac ccagacatga aaaaagtagc
     5041 aggaatcgat atgtctactg gttctcttgg tcaagggcta tctgcagcaa atggtatggc
     5101 acttgcagga aaattagata acaaagacta tacagtatat actatattag gtgatggaga
     5161 aatccaagaa ggtcaaatat gggaagctgc aatgacagca tcacattaca aattagataa
     5221 tttaattgca tttgttgact taaatggatt acaaatagat ggttctaatg aagaagtaat
     5281 gaatgtaagt ccagtagatg acaaattcaa atcttttgga tggaatgtaa tagtaataaa
     5341 tggacattct tttgaagaaa taggaaatgc agttgatgaa gctaaaaaag ttacaggaaa
     5401 accaactgta ataatagcta aaacagtaaa aggtaaaggt gtttcattta tggaaaataa
     5461 tgctgcatgg catggaacag ctccaaatgc agaacaagca gagcaagcat tgaaagattt
     5521 agaaggaggt ctataggaat gggaatagca actagagaag cttacggaca agtgttaaaa
     5581 gaacttgcag aaaataaaga tatagtagta ttagatgcag atttaggaaa agctacaaaa
     5641 agtatatcat ttaaagaagt tgccccagat agattttttg acatggggat agcagaaggt
     5701 gacatgattg gtacagcagc aggtcttgct acttgtggaa aaataccttt tgcgagtact
     5761 tttgcaatat ttgcagcagg aagaggctat gagcaaataa gaaactctgt agcatatcca
     5821 aatttaaatg taaaaatagc agctactcat gcaggtgtaa cagtaggtga agatggtggt
     5881 agccatcaag ctatagagga tatatctcta atgagaggta taccaaatat ggttgtatta
     5941 aatccagcag atgctttaga agcaagacaa gctattctta catctattga ttataatgga
     6001 cctgtttata taagattagg tagagctgca actcctgatg taaacagtga aaattataaa
     6061 tttgaaatag gaaaaggaac tgttttaaga gaaggttctg acataacagt aatagctaca
     6121 ggaataatgg tagcaaaagc cttagaagca gcagaagaac ttgctaaaga aggtataaat
     6181 gtagaagttg ttaatatatc tacaataaaa ccattagatg aagcattaat aaaagaaact
     6241 gctaagaaaa ctggaaaagt agttacagca gaggagcaca gtataatagg tggtttaggt
     6301 tcagctgtat gtgaagcttt agcagaaact aaagatgtag tagttagaag aattggtgtt
     6361 aaagatgtat ttggtcaatc aggtacacca gctgatttat taaaacacta tggtttaact
     6421 acagaagata tagtaaaaaa tataaaagag ttgttataga tataaatata tctaaataac
     6481 aaattgattt gacataagtc aattaaagct gtcttaaaaa tagaaagaaa tttctacaat
     6541 gggacagctt tatttttaca atactttatt tttatgataa ttataaaata gtctgaaagt
     6601 aatcaaaaaa attataaaaa gaggtgctat ttaatgaaaa tatctattgg atgtgaccat
     6661 ggtggttatg aattaaagga atatataaag gaaaatttaa taaataaagg tatagaagtt
     6721 gaagatgtgg gtacaaattc aaaagaaagt gtagattttc caatatatgc aaaaaaggta
     6781 agtcaaaatg ttcaaagtaa aaaatctgat ttaggcatac tttgttgtgg aacaggaata
     6841 ggtatgtcta ttgcagcaaa taagtttaaa ggaatcagag cagctgttgt ttctgactgt
     6901 ttttcagcta aggcaactag agaacacaat aatacaaatg tactttgttt aggagaaaga
     6961 gttattggga aaggattagc aatgagaatt gttgaagaat ggttaaattc aagttataat
     7021 ggagaaagac atgcaagaag attacaaatg attgatgata tagaaaaaga aaatttataa
     7081 atatataatt tataacaagg gggagcgtta tgtctattat ttgtgcttca ataatgtgtg
     7141 cagaccaaat gaagttaaaa gaggaattag aagctcttga agaagcaggt gtaaaattac
     7201 ttcattgtga tgttatggat ggaatatttg ttaaaaactt ggctatggga ccagagttat
     7261 taaaatcaat aagtgaaaat acaacaatac ctttagacat acacttagcc acagaaactc
     7321 cagataaata tattgatatg atgtcttata taaagccaaa atatatttct tttcatgtag
     7381 aatcaagtac aaatgtaaaa gctgatatac aaaagttaag aaattatggt atagggccag
     7441 tgttagcaat aagccctcaa acaagtgtgg ataaaataga agaatatata agtttagttg
     7501 agggtatctt agtaatgaca gtaaatccag ggtttgcagg tcaaaagttt aatctttctg
     7561 tattggataa gttggataaa cttacagaga tactaaaaga ttatgataat cctccattta
     7621 tagaggttga tggaaatata aataaggata ctattaaact tatgaatggt aaaaaagtag
     7681 atatatatgt tgttggtact tcagctttat ttaatgataa gcctccaatt tcatataaag
     7741 ataaaataga agaactaaaa gaaagtataa agtaaccatg taataaaatt ataatatgtt
     7801 tctgtttaat agtaaaaatt taggtggaaa caagaaattt tataatattt aataaaaatt
     7861 ttggttgagt aaggagaatt ttttatggga gacctatata aactacaaaa tggtactgat
     7921 attagaggaa tagcgtatga aaatgattct aaagaagtta acctaactgt agaagaagta
     7981 aaaaaaatag ctaaagcgtt tcatatttgg ttaaaagaaa agactaagaa agataaagta
     8041 actgttgcca taggaactga ttctaggata acaggaagcc aatttagaag tactgttatt
     8101 gaaactttaa ctaatgacga ttgtaatgta attgattgtg agattgccac aactccagct
     8161 atgtttatga caactattat ggatggatac aattctgatg gggcgattat gattacagca
     8221 agtcacttac cttattacta taatggttta aagtttttca cagaaagtgg aggtttagaa
     8281 aaaactgata taaaagagat gttggatata gctgttaaaa atgatagtgt agactatgag
     8341 gaagtaaata aaaaaggtga agttatagta aaaaatttaa tagaagatta ttctaattta
     8401 ttgatagata aaattagaaa aggtgtaaat tcaagtaaaa attatgaaaa gcctttttct
     8461 gggcttaaga tattggttga tgcaggaaat ggggctggtg gattctttgc tgaaaaagtt
     8521 ttacacatac tgggagcaga tacgacaggt agtcagtttt tgaacccaga tggtatgttc
     8581 ccaaatcata tacctaatcc cgaaaacaaa gaagcaatgg aaagcatatg taaagctgtg
     8641 ttagataata agagcgacct aggaataatc tttgatacag atgtagacag agctgctatt
     8701 gtaggtaaaa atggcaaacc aataaataaa aatgctctta tagctgttat atcatcaata
     8761 gtattagaag aacatccaaa aacagctata gtaacagatt cgattacttc tgaaggactt
     8821 gctaaattta taaatgaatt acaaggaaga catcatagat ttaaaagagg atataaaaat
     8881 gtaataaatg aagctataag attgaatagt gaaggtgaag agtgccattt agctatagaa
     8941 acgtctggac atgctgcttt aaaagaaaat tatttcttag atgatggggc atatttaata
     9001 gctaaaattt taataaaagt agcaaagcta tccttggaag gaaagactat agaagaattg
     9061 atagaaaacc ttgaagaagc tcaagaagag aaagaagtta gaataggcat taataaagaa
     9121 gattttagac catatgcaga ggatatatta aaagatttag attctcatgt caagagtatt
     9181 gatggatggt ctgtagcacc aaataatttt gaaggcataa gagttaattg tgatgaatca
     9241 aatggagatg gatggttttt acttagaata tcactacatg aaccattatt agctttaaat
     9301 attgaatcaa ataaaattgg cggagcagaa caaatttatt ctaagttaaa acttttctta
     9361 gaaaaatatg atttaaaagg tctttagggt aaatagaaag aatatattta tattgaagaa
     9421 taaatgtaaa tttgtaccta agattacaaa tattacaaaa ttgtaatctt aggtaacaga
     9481 gatgtaactg attatggaaa cactatgtga tattatagat acagagagat gaaatatgtg
     9541 atgaattata gagaaatata atttaaaatg tattaatatc acaccaaaaa ggtataatca
     9601 aaaaatatgt aaatataaac cccaacattt agaagaagac ctctaaggag gtttttttct
     9661 tgtttaaata acttaaaata tatttttata tcaatatatc aattaactct tctaaaagta
     9721 agcattacct taaataaatc agcatctata attatttcca tgtgtgcatt ttctaattca
     9781 attatatttt gagcaattga taaaccaaga ccagagccat ctgtttttct agatatatca
     9841 ccccttctaa atctttctat taactcttct ggctttagat ttagtttatc atttgaaata
     9901 tttttaaacg ttaatattat attttcttcc tttataaaca tatctatgta gaccctagtg
     9961 ttaggcatag agtattttag tatattgcaa attagattct caaaaactct ccaagttttt
    10021 ttaccatcta tcatggtaaa aacagcatat tcaggtgttt ctattataaa atctaaactg
    10081 ctattttgaa ttttgtcttc aaactctaca atactttgaa ttaaaagttc tcttatatcg
    10141 gtttttgtta tattaaattc tacatctcca ctacttagct tagatgcttc aaatatgtca
    10201 tctattaata attttaatct ttgtgatttt ttatctaaaa tatttatata gtcatttata
    10261 gtctctctgt caaagtcatt attttttaac atatcaacat agcttaatat agatgtaagt
    10321 ggagttttta agtcatgaga tacgtttgtg ataagctctg ccttcatcct ttcatttttt
    10381 atattagcat ctacagcagt ttcaagacca cctgttatat tatttatact tttggctaaa
    10441 gtagatattt catcatctcc tataacttct aatttatact ttaaattgcc attttctata
    10501 ttttttatat tttttgatat gttatttatg taattaaact taacagataa aaagttgtat
    10561 atataaaaat gaaaaactgt gtttacaagt gtaaataaaa ttactatagc tattgcctca
    10621 gcataatata tatacataaa gaatatcaaa acaagatatt ggataatagc ttgtacaact
    10681 atagatatta aaaatactat agctaatttt ttatttatag tttttttatt atacatatta
    10741 agcaagtttg aaaaaaatac atatgttata gacatatctt ttagattata gtt
//
LOCUS       DAEHWM010000111        10747 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.114, whole genome shotgun sequence.
ACCESSION   DAEHWM010000111 DAEHWM010000000
VERSION     DAEHWM010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10747)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10747)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10747
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.114"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            236..1420
                     /locus_tag="KNP36_003223"
     CDS             236..1420
                     /locus_tag="KNP36_003223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453637.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875072.1"
                     /translation="MQKSVKKAKVTGSMLAIFGVASVLFSSHAGGGFATGNQETQYYV
                     QYGWTAPLMAILAMIILTATMREVIIMYNNNNCRNYKDLFCELWRPYPKLEIIWEIYY
                     YLMVLIAVSAVIAGAAAVFQSIGVNYFVAVFIIGVVLLVFTIFGAMLVSKAATAMTIA
                     ILVCTLTIFIVGIKAKVPEITEILSNRTSFTPGYIKPILNTFIYAGFQSVVIPTLAGC
                     SRPLLKNSKEATKAMIISFVMNAIALGLAVTMLMGWYREIIAAGQTTLPTLYVAGQSG
                     NHTIYIIYNVALFLCLMSTGVTTIFGLVNRFEDHKALSFLSSRMKRRVFTACAIMVVS
                     MLISLTGLSNIVKYGYGYCGYLGLFTIVIPFLTLGHYKNKKFAKENPEAKWPAELNEN
                     VN"
     gene            complement(1797..2906)
                     /locus_tag="KNP36_003224"
     CDS             complement(1797..2906)
                     /locus_tag="KNP36_003224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HBF0875073.1"
                     /translation="MDFKSLGISENTINILKKSGITTPTPIQKESIKLIKEGKDVIAE
                     AQTGTGKTLAFLLPIFENISLDINDIQVLILSPTRELAIQITEEAMKLKESKDVSILA
                     AYGGKDIGSQIKKLKGNIHMIIATPGRLLDHLNRKTIDLSKLKTFVLDEADQMLLMGF
                     KNEVEAILKETSNKKQTLCFSATINSQVKKLAYRYTKNPVVVSIQKEEITLNNIKQEV
                     VETTDRKKLDALCKVLDEDNPFMAIIFCRTKRRVDNLEEALAIRGYNCQKLHSDIAQS
                     KRERIMKSFRNLDIQYLIATDVASRGLDISGVSHIYNYDLPETPEDYIHRIGRTGRAG
                     EEGYTCAFIDPKNERMLSEIETAIESKISRRIIEL"
     gene            3369..4562
                     /gene="nifV"
                     /locus_tag="KNP36_003225"
     CDS             3369..4562
                     /gene="nifV"
                     /locus_tag="KNP36_003225"
                     /EC_number="2.3.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homocitrate synthase"
                     /protein_id="HBF0875074.1"
                     /translation="MCVISKDRAKEIKIVDTTLRDGEQTAGVVFANREKIMIAEMLSD
                     LGVDQIEVGIPTMGGDEKNVIKHICSRNLKSDIMAWNRAVIKDVEESISCGVDAVAIS
                     ISVSDIHIENKLRTSRGWVLENMAKTVEFAKKNGLYVSVNGEDASRADIDFLTEFINV
                     GKQAGADRFRYCDTVGVMNPFSIKNAIETLYERTNFDIEMHTHNDFGMATANALAGIA
                     AGANYVGVTVNGLGERAGNAALEEVLMALKCVYKCDLNNIDTRKFRGICEYVAQASGR
                     ILPTWKPVVGDNMFIHESGIHADGALKDPHNYEPFDPSEVNLERKIVIGKHSGRAAVV
                     NKLSEYEMYISPENATKLLNAIRATSIRLKRSLMDKEILQLYCDILAHEKGTTEEEAV
                     RGSYI"
     gene            4587..6512
                     /locus_tag="KNP36_003226"
     CDS             4587..6512
                     /locus_tag="KNP36_003226"
                     /EC_number="4.2.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aconitate hydratase"
                     /protein_id="HBF0875075.1"
                     /translation="MGDNIVYKIIKKHIVDGEAVAGSSIGIKIDQTLTQDSTGTMTYL
                     QLEAMGIDKVKTKRSVAFVDHNMLQQGFENADDHKYIQTVADKYGVYFSKPGNGICHQ
                     VFLERFSTPGDTLLGSDSHTPTAGGVGMMAIGAGGLDVALAMAGGAYYIKAPKVCKVN
                     LVGKLNNMVSSKDIILEVLRKQTVKGGVGKVYEYGGEGVKSLSVPQRATITNMGAELG
                     ATTSIFPSDEKTLEFFKSQGREDAWVELKPDADAVYDEEITINLDELKPLAAKPHSPD
                     NVDEVENIGKIKIDQVAIGSCTNSSYEDLMKVAQILKGNKVHKDVSLVIAPGSRQVME
                     MIARNGALADIISAGARILENSCGPCIGMGQSPGTDSVSLRTFNRNFYGRSGTLSAQV
                     YLVSPEVAAVSAIKGVLTDPREFDIKFTNLDVNEFLIDDSMIIKPADVGSDVEVVRGP
                     NIKPFPLNTELSQSIGGKVILKTEDNITTDHIMPSNAKLLPFRSNIPYLANYCFNTVD
                     TEFPQRAKDNNGGFIVGGDNYGQGSSREHAALAPLYLGVKGVIVKSFARIHKANLINS
                     GIIPMEFCDEKDYENISLLDNLEIPNILDNLGSGILEVKNTTKGTSFKVKVELSAKEV
                     DVLKAGGKLNYTKNQAN"
     gene            6534..7529
                     /locus_tag="KNP36_003227"
     CDS             6534..7529
                     /locus_tag="KNP36_003227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isocitrate/isopropylmalate dehydrogenase family
                     protein"
                     /protein_id="HBF0875076.1"
                     /translation="MYKVTLIPGDGIGPEVAKAMKKVVEATGVEIEWEEVNAGEAVIE
                     EYGTPLPEYIIDSIKKNKIAIKGPITTPVGKGFRSVNVTLRQALDLYVNLRPIKSFKG
                     IKSRYEDVDLVVVRENTEDLYAGIEHKIGDYAAESIKIITRSASERIVDFACNYVKDN
                     KRKKVTAIHKANIMKMSDGLFLDVFREVASKHGVEYDDLIVDAAAMNLVLNPENYDVM
                     VMPNLYGDILSDLGAGLVGGLGIIPSANIGKDCAIFEAVHGSAPQIAGQNKANPTALI
                     QSSVMMLRYLGEYENAQKIETALEKVFLEGSKLTVDLGGSASTTEFADEVCKYIV"
     gene            7854..8327
                     /locus_tag="KNP36_003228"
     CDS             7854..8327
                     /locus_tag="KNP36_003228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0875077.1"
                     /translation="MVVSVEVCLIKTLDSNILREVGTLSRAVNSINDIKYKELKLQKG
                     QFTFLTRICENPGINLVELSNMLKVDKATTTKAIQKLIKAGYVDKKQDKFDKRGYNLT
                     PTDKSLEVYELIIEEENRSIEICFDNFTDEEKQVVTKLLEKMSKNVENEWFKVKR"
     gene            8361..8855
                     /locus_tag="KNP36_003229"
     CDS             8361..8855
                     /locus_tag="KNP36_003229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0875078.1"
                     /translation="MIRKANMNDLESIMKIIKSTVEEMKTYNNTQWDENYPLEKDFVS
                     DIKKQDLYIYEVDGEVAGFICLNYEEPEEYLGLNWSSNKKAMVIHRMAVNPNFRKTGI
                     ASKLVDFAEKLAVENNVSYLKSDTYSINSKMNLLLTKCGFIKIGEMSFLGKEKSFYCY
                     DKIL"
     gene            8952..9473
                     /locus_tag="KNP36_003230"
     CDS             8952..9473
                     /locus_tag="KNP36_003230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HBF0875079.1"
                     /translation="MIGFLKKRRSIRKYKDVEVEKEKLDKILKAALLAPSSKGLRTWE
                     FIVVDDKEKLINLSQCRTKGGGFFLKNAPLAIVIIADKEKNDVWIEDASIAASYIQLQ
                     AHELGLGSCWIQVRNRMHDDNIEADKYIREELKVPSKYSVECIISIGYPDEEKKAYGD
                     SDLDYKKVHFNNF"
     gene            9662..9973
                     /locus_tag="KNP36_003231"
     CDS             9662..9973
                     /locus_tag="KNP36_003231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HBF0875080.1"
                     /translation="MGIFKTKMDEDWKVNYIKEFNEMRDSYESKLQKKQFEVDSLKSE
                     LDRLRSYKNSLKPKEKQITDDDINNIKSLRRDGLSYKEISNQTSWSKATVSRVLNGLY
                     D"
     gene            10001..10687
                     /locus_tag="KNP36_003232"
     CDS             10001..10687
                     /locus_tag="KNP36_003232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBF0875081.1"
                     /translation="MKYSYKKCIIDSILLMFIVQILRMILNYVLLSQFEFTLENFNII
                     NLISFTLVGLSLILFLKDNSLYNKVRNRKITEAFEENKNNILIEKCKLILFVVVLSLA
                     IIVTYCTKGYVLFNVTMMTLSVLIVPIFEELFFREYIWNYLSNFIKSKSKIICITSIL
                     SGIYNIGYIDVIRNYVILYNNSSYTFEVIISKIMIGTVFGIVLGLVKYRFRDVGFCIL
                     LRSLFAIFIR"
BASE COUNT         4113 a         1170 c         1942 g         3522 t
ORIGIN      
        1 ataatattta acattaaaaa agatatttca taaaattaaa aaacaaagtg aatttgaata
       61 ctatttaaaa aataaaataa atatataaaa aatatttaat ataaaggtgg aaataagttg
      121 aaaatgtaaa gtcattggaa aaatatagtt gaatttaatg agcaaaaatg ttattgtttt
      181 atcaataaag tgttaaaata aaaactttca atatcatttt agggaggatg atttcatgca
      241 aaaaagtgta aagaaagcaa aagtaacggg ctctatgtta gctatttttg gtgttgcaag
      301 cgttcttttt agttcacatg caggaggagg atttgctaca gggaatcaag aaactcagta
      361 ctatgtgcag tatggatgga cagcaccact tatggcaatt ttagcaatga ttatacttac
      421 tgctaccatg agagaagtta tcataatgta taataataac aattgtagga attataagga
      481 tttattttgt gagctttgga gaccatatcc aaaacttgaa ataatatggg agatatatta
      541 ctatctaatg gttttaatag ctgtaagtgc tgttatagca ggtgcagcag cagtatttca
      601 aagtatagga gtaaattatt ttgtagctgt atttattatt ggagttgtac ttcttgtctt
      661 tactatattt ggtgctatgc ttgtatctaa agcagctaca gcaatgacaa tagctattct
      721 agtatgtact cttactattt ttattgttgg tataaaagct aaagtaccag aaataactga
      781 aatattatca aatagaacga gtttcacacc tggctatatc aagccaatac ttaatacttt
      841 tatttatgca ggttttcaat cggttgttat acctacactt gcaggatgtt caagaccact
      901 tcttaagaac tcaaaagaag ctactaaggc aatgataatt tcatttgtta tgaatgcaat
      961 tgcattagga cttgctgtaa ctatgctaat gggatggtat agagaaatta ttgctgctgg
     1021 gcaaacaaca ctccctactc tttatgttgc aggtcaatct ggaaatcata ctatatacat
     1081 aatttataat gttgcattat tcctttgttt aatgtctaca ggagtaacta ctatatttgg
     1141 tcttgtaaat agatttgaag accataaagc actttctttc ctttcttcaa gaatgaaaag
     1201 aagggtattt acagcttgtg caataatggt agtgtcaatg cttatatcac ttacaggatt
     1261 aagtaatatt gttaaatatg gatatggata ttgtggttat cttggtctat tcactatagt
     1321 aattccattt cttacactag gacattataa gaataagaag tttgcaaagg aaaatccaga
     1381 agctaaatgg ccagcggaat taaatgaaaa tgtaaattag atgtagtagc aaaaaatatt
     1441 gctaaagaga atactataaa taagaatact atagataata tatctgcatg tttattaaga
     1501 ttatttgcaa aatctaatat taaacaacta taaacaagca atataaaact aagaataaaa
     1561 gataaaaaga gggtatctca aaatggactt ttagtttata aggcactctt ttttatatga
     1621 agtcaaatat attttcatta ttttgacaat aaaagagact aatcctactt tggatagcct
     1681 cttttttctt taatataaaa tagtataaca gcaaagtata gattgataca tgttttctgt
     1741 agctttctat atattacagt gtttgtgtgg cattggtatt ttaagcaatc tataaattat
     1801 aattctataa ttcttctact aattttagat tctatagccg tctctatttc acttaacatt
     1861 cgttcatttt tagggtcaat aaaagcacat gtatagcctt cttcaccagc tctaccagtt
     1921 ctaccaatac ggtggatgta gtcttctggt gtttctggta aatcgtaatt atatatatga
     1981 cttactccag atatatcaag accacgagaa gctacatctg tagctattaa gtattgtata
     2041 tctaaatttc taaatgattt cattattctt tctcgttttg attgagcaat atcactatga
     2101 agtttttgac aattatatcc tcttatagca agagcttctt caagattgtc aacccttctc
     2161 ttagttctac aaaatattat tgccataaaa ggattatctt catctagtac cttacataag
     2221 gcatctaatt tttttctatc tgtagtttct actacttctt gttttatatt attaagagtg
     2281 atttcttctt tttgaataga aactacaaca ggattttttg tgtatctata agctaatttt
     2341 tttacttgag aatttatagt tgcagaaaag catagtgttt gctttttgtt tgaagtctct
     2401 tttaaaatag cttccacttc atttttaaat cccataagca acatttggtc tgcttcatct
     2461 aaaacaaaag tctttaactt actaaggtct attgtttttc tatttagatg gtctaaaagc
     2521 ctacctggtg tagctataat catatgaata tttcctttta gtttctttat ttgagaacca
     2581 atatcttttc ctccatatgc tgcaagaata cttacatctt tagattcttt aagtttcata
     2641 gcttcttctg ttatttgaat agctagttct cttgtaggag aaagtataag tacttgtata
     2701 tcatttatat ctaatgatat attttcaaat atcggaagta aaaaagctag tgtttttcct
     2761 gttccagttt gagcttctgc tattacatct tttccttctt ttattagttt aatactttct
     2821 ttttgtatag gtgtaggtgt tgttattcct gattttttta gaatatttat tgtattttca
     2881 ctaatcccta agcttttgaa atccattgtt atcttacctt tcatgaaaaa ttttcttttt
     2941 tattaaccaa ttaataatat catatttgta agtattttta gtaaattttt taattattat
     3001 ttatatagct taaaaatata ttaagatact ttaaaatgga atgtaactta aattaaattt
     3061 tagtaggaat tttataggtt tatttttaaa ggttttttga aaataaatct atttaaaaat
     3121 taaattaaaa tgcaagaaaa acataataac tttcattttt aagaagtttt cacaaaaaag
     3181 aaaaaatata gtgcaataaa tgatacaaag taatataata gattacaaga tatgaaaagc
     3241 taaaaaaata aattgcaaat gaaattaaaa tgaataaaaa ataaaaaaat aatcataagt
     3301 tagaagtatc aatgaaaaat aagacttaat gtttttaaaa ttaaaagtat actaaggggg
     3361 gcattaatat gtgcgttata tcaaaagata gagcaaagga aataaaaata gtagatacta
     3421 ctttaagaga tggagagcaa acagctgggg ttgtatttgc aaatagagaa aaaataatga
     3481 ttgctgaaat gttaagtgac ctaggtgttg accaaattga agttggtata cctactatgg
     3541 gtggagatga aaaaaatgta ataaagcaca tatgtagtag aaatttaaaa tcagatataa
     3601 tggcttggaa tagagcagta ataaaagatg ttgaagaatc tatttcttgt ggtgttgatg
     3661 cagtagctat atcaatatca gtatctgaca ttcatataga aaataaattg agaacttcta
     3721 gaggctgggt tttagaaaat atggctaaaa cagttgaatt tgcaaagaaa aatggattat
     3781 atgtttcagt aaatggagaa gatgcttcaa gagcagatat agacttctta actgaattta
     3841 taaatgttgg aaaacaagca ggggcagata gatttagata ctgtgataca gtaggagtta
     3901 tgaatccttt ttctataaag aatgcaatag aaactcttta tgaaagaact aattttgata
     3961 tagaaatgca tacacataat gactttggga tggcaactgc aaatgcactt gcaggaatag
     4021 cagcaggagc aaattatgtt ggtgttacag taaatggatt aggtgaaaga gcaggaaatg
     4081 cagcattaga agaagtttta atggcactta agtgtgttta taaatgtgat ttaaataata
     4141 tagatactag aaaatttaga ggaatatgtg agtatgtagc acaggcatca ggaagaatac
     4201 ttcctacatg gaaaccagta gttggggata atatgtttat acatgaatct ggtatacatg
     4261 cagatggagc tttaaaagac ccacataact atgaaccatt tgacccaagt gaagtaaatc
     4321 ttgaaagaaa aatagtaata ggtaaacatt caggaagagc tgcagttgta aataagttga
     4381 gtgaatatga aatgtatatt tctccagaaa acgctaccaa gctattaaat gctataagag
     4441 ctacatctat aagattaaaa agaagtttaa tggataaaga aattcttcaa ttatattgtg
     4501 atatactagc acatgagaaa ggcacaacag aagaagaagc agttagaggt tcatatattt
     4561 aagatataat tgtttaggag gaaaatatgg gagataatat agtttataaa ataattaaaa
     4621 aacatatagt agatggagaa gctgttgctg gaagttcaat tggtataaaa atagaccaaa
     4681 ctttaacaca agattctact ggaacaatga catatcttca actagaagct atgggaatag
     4741 ataaagtaaa gactaaaaga agtgtggcat ttgtagacca taatatgtta caacaaggat
     4801 ttgaaaatgc agacgaccat aagtatatac aaacagtggc agataaatat ggagtttatt
     4861 tctctaagcc aggaaatggt atttgtcatc aagtattttt agaaagattt tcaacaccag
     4921 gagatacact tttaggttct gatagccaca cacctactgc tggaggtgtg ggcatgatgg
     4981 ctattggagc tggtggatta gatgttgctt tagccatggc aggaggagca tactatataa
     5041 aagcaccaaa agtctgtaag gtgaatctag ttggaaaatt aaataatatg gtatcatcaa
     5101 aagatataat attagaagtg ttaagaaaac aaactgtaaa aggtggagta ggtaaagttt
     5161 atgaatatgg tggagaaggt gtcaaaagcc tatctgttcc acaaagagct acaataacaa
     5221 atatgggggc tgaacttgga gcaactactt caatcttccc aagtgatgaa aaaacactag
     5281 aattttttaa gagtcaagga agagaagacg catgggtaga gctaaaacca gatgcagatg
     5341 cagtttatga tgaagagatt actataaact tggatgaatt aaaaccatta gctgcaaaac
     5401 ctcatagccc agacaatgta gatgaagttg aaaatatagg caagattaaa atagaccaag
     5461 tggcaatagg aagttgtaca aattcttctt atgaagactt aatgaaagta gcacaaatcc
     5521 tgaaaggaaa taaagtacat aaggatgtga gtttggtaat agcaccaggt tcaagacaag
     5581 ttatggagat gattgctaga aatggggctt tggcagatat aataagtgct ggagctagaa
     5641 tactagaaaa ttcttgtggt ccatgtattg gtatgggtca atctccaggt actgactctg
     5701 tgtctttaag aactttcaat agaaatttct atggtagaag tgggactttg tcagcacaag
     5761 tatatttagt aagtccagaa gtggcagcag taagtgcaat caagggagtg cttacagacc
     5821 caagagaatt tgatattaaa tttacaaatt tagatgtaaa tgagtttttg atagatgata
     5881 gcatgataat taaacctgct gatgtaggaa gtgatgtaga agtagttaga ggacctaata
     5941 taaaaccttt ccctcttaat acagagctaa gtcagtctat aggtggaaaa gttatattaa
     6001 agacagaaga taatataact actgaccata taatgccatc aaatgctaag ttacttcctt
     6061 ttagaagtaa tataccgtat cttgcaaact attgtttcaa tactgtagat acagaatttc
     6121 ctcagagagc aaaagacaat aatggtggat ttatagttgg tggagataat tatggtcaag
     6181 gttcaagtag agaacatgca gctttagcac cattatatct aggtgttaaa ggggtaatag
     6241 ttaagagctt tgcaagaatc cacaaggcta acttgataaa tagtggtata attccaatgg
     6301 agttttgtga tgagaaagat tatgaaaata tatctctttt agataatctg gagataccaa
     6361 atattttaga caatctaggt agtggaattt tagaagttaa gaatacaact aaaggaactt
     6421 cttttaaggt caaagtagaa ttgtcagcaa aagaagttga tgtattaaaa gctggtggaa
     6481 aattaaacta cactaaaaat caagctaatt aatatgaaaa gagggaatat tgaatgtata
     6541 aagtgacact tataccagga gatggaatag gaccagaagt tgcgaaagct atgaaaaagg
     6601 tagtagaagc tactggagta gaaatagaat gggaagaagt taatgcagga gaggcagtta
     6661 ttgaagagta tggtactcca cttcctgaat atattataga tagtataaaa aagaacaaaa
     6721 tagctataaa aggcccaatt actactcctg taggtaaagg atttaggagt gtaaatgtaa
     6781 ctttaagaca ggcattagat ttgtatgtca acttaagacc tattaaaagt tttaagggga
     6841 taaaatcaag atatgaagat gttgatttag tggttgtaag agaaaataca gaagatttat
     6901 atgctggaat agaacataaa ataggtgatt atgcagctga aagtataaag ataataacaa
     6961 gaagtgcaag tgaaagaatc gttgattttg catgtaacta tgttaaagat aataagagaa
     7021 aaaaagttac agctatacat aaggcaaata taatgaaaat gtctgatgga ttgtttttag
     7081 atgtgtttag agaagttgca tcaaaacatg gtgtagaata tgatgatttg attgtagatg
     7141 cagcagctat gaacttagtt ttaaatccag aaaattatga tgtaatggta atgccaaatc
     7201 tttatggaga tatactatca gatttaggtg ctgggcttgt tggaggttta ggtataattc
     7261 caagtgcaaa tattggtaaa gattgtgcga tatttgaagc tgttcatgga agtgctccac
     7321 aaatagcagg tcaaaataag gctaatccaa cagcacttat tcaatcatca gtaatgatgc
     7381 ttagatactt aggtgaatat gaaaatgcac aaaaaataga aacagcttta gaaaaagtat
     7441 ttcttgaagg aagtaaattg actgtagatt taggtggctc agcttctact acagagtttg
     7501 cggatgaggt gtgtaagtat attgtataga ttttatttag ggaaaaagta aaatatagat
     7561 tgaagaaaag aggctttctc aaaatagaga taagcctttt ttattggaat gataaaatat
     7621 atttgatttt atacaaaaga gagttcctca taaacgaaaa agttaatttt gggatatcca
     7681 ttttaatttt aaaattaatt gattaatacg caaagaaaga ttaaataaat ttattatttt
     7741 taattgaact ttcaaccaaa atatggtaaa atttaaaaag ttgaactttc aactaaaaat
     7801 gaaaatattg attatgtgaa attctataaa acagaaacta tttgacttta gccatggtag
     7861 tttcagtgga ggtgtgtttg attaagactt tagatagtaa tatattaaga gaagtaggta
     7921 ctttatctag agcagtaaat tcaataaatg atattaagta caaggaatta aagttacaaa
     7981 aaggacaatt tacatttttg acaagaatct gtgaaaatcc tggtataaat cttgtggaat
     8041 tatcaaatat gttaaaggta gacaaggcta caacaaccaa ggctatacaa aaattaataa
     8101 aggcaggata tgtagataaa aagcaggata agtttgataa aagaggatat aatttaactc
     8161 caactgataa atctttggaa gtttatgagt tgataattga agaagagaat agaagtatag
     8221 agatatgttt tgataatttt acagatgaag aaaaacaagt ggtaactaag ttattagaaa
     8281 aaatgagcaa aaacgtagaa aatgaatggt ttaaagtaaa gagatagtaa ataaatacat
     8341 taacttaagg agatattttt atgattagaa aagcgaatat gaatgattta gaaagcatta
     8401 tgaaaattat aaaatctaca gtggaagaaa tgaagactta taataataca caatgggatg
     8461 aaaactatcc attagaaaaa gactttgttt cagatattaa gaaacaagat ttatatattt
     8521 atgaagtgga tggagaagta gcagggttta tatgtcttaa ttatgaagag ccagaagaat
     8581 atttaggctt aaattggtca tctaataaaa aagcaatggt aatacataga atggctgtaa
     8641 atccaaactt tagaaagaca ggaatagcat ctaagttagt tgattttgct gaaaaattag
     8701 ctgtagaaaa caatgtatca tacttaaaga gcgatacata ttcaataaac tcaaaaatga
     8761 atttattact tacaaagtgt ggttttataa aaatcggaga aatgagtttt ttaggaaagg
     8821 agaaatcttt ctactgttat gataaaatat tataaagagc atttataata caaggggtaa
     8881 ataatagatt ttcagcatta gtaagggcat aatataacct agtatatgct attatgaaag
     8941 ggatgattta tatgattgga tttctaaaga aaagaagaag tattagaaaa tacaaggatg
     9001 ttgaagtaga aaaagaaaaa ttagataaaa tattaaaagc tgctctttta gctccatcat
     9061 caaaggggct tagaacatgg gaatttatag tggtagatga taaagaaaag ctaattaatt
     9121 tatctcaatg tagaactaaa ggtggtggat ttttcttaaa aaatgcacct ttagctattg
     9181 taattattgc agataaagaa aaaaatgatg tttggataga ggatgcaagt atagctgctt
     9241 catacataca acttcaagct catgaactag gtttaggttc ttgttggata caagtaagaa
     9301 atagaatgca tgatgataat atagaagctg ataagtacat tagagaagaa ttaaaagtac
     9361 ctagcaagta cagtgtagaa tgtataattt ctataggata tcctgatgaa gaaaagaaag
     9421 catacggtga ctctgattta gactataaaa aggttcattt taacaacttt tagtatataa
     9481 tatgttgtat taagacatta tatttttttc tattgttaat atatacttaa aattgtaaaa
     9541 atatatctga attttactaa cttatctagg ggttatgtac aaggatttta aagataaata
     9601 tagaaattaa tgtttataat cgatacataa cttgagtaac aaaatttaag gaggttaaag
     9661 tatgggtata tttaaaacaa aaatggatga ggactggaaa gtaaactaca ttaaagagtt
     9721 taatgaaatg agagattctt atgagagtaa acttcaaaaa aaacagtttg aggtagatag
     9781 tttgaaatca gaattggata gactaagaag ctataaaaat agccttaagc caaaagaaaa
     9841 acaaattact gatgatgata taaataatat aaagagttta agaagagatg gcttaagcta
     9901 taaagaaatt tcaaatcaaa caagttggag caaagcaact gtaagtaggg tattaaatgg
     9961 actttacgat tagcatatac atggggtgat ttaaattggg atgaagtata gttacaaaaa
    10021 atgcataata gattctattt tattgatgtt tatagttcaa atattaagga tgattttgaa
    10081 ttatgtactt ctaagtcaat ttgaatttac tcttgaaaat tttaatatta taaacttaat
    10141 ttcttttaca ttagttggtt tatcgttaat tttattttta aaagataatt ctttgtataa
    10201 caaggttaga aatagaaaaa tcacagaagc ttttgaagaa aataaaaaca atatacttat
    10261 tgaaaagtgt aagctgatac tttttgttgt ggttttatct ttagcaataa ttgtaactta
    10321 ttgtactaag ggatatgtac tttttaatgt aactatgatg actttgtctg tattgatagt
    10381 cccaatattt gaagagttat tttttagaga atatatatgg aactatctaa gtaattttat
    10441 aaagtcaaag agtaaaatta tctgtataac atctatacta tctggaattt ataatatagg
    10501 atacatagat gttataagaa attatgtaat attgtataac aattcaagct acacctttga
    10561 agttattatt tcaaaaatta tgataggtac tgtttttggt attgtacttg gattagttaa
    10621 gtataggttt agagatgtag ggttttgtat attattgagg agcttatttg ctatatttat
    10681 taggtagata gtataatcgg tttataaggt tgttttaaat ttaattttaa atcaacctta
    10741 ttttatt
//
LOCUS       DAEHWM010000112        10634 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.115, whole genome shotgun sequence.
ACCESSION   DAEHWM010000112 DAEHWM010000000
VERSION     DAEHWM010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10634)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10634)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10634
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.115"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(584..1318)
                     /locus_tag="KNP36_003233"
     CDS             complement(584..1318)
                     /locus_tag="KNP36_003233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0875082.1"
                     /translation="MNLAKGLDVLKISSNVFGEDKVMYIPVIYTEDDATLIDTGLPGQ
                     GDLIIDALNKSNTSFDKLKNIIITHHDIDHIGNINYLREKSKNNIKVYAYKSEISYIT
                     GEETPFKLYMLEQMVDKIDDKMLSMLNVMGLGFKSSYTKVDVSLDNHEKLNLGEEIEV
                     IHTGGHTRGHICLYLKESKVLIAGDLLQVENGELKPVDVMHSNKQELKDAIKNISNYD
                     IETIVFSHGGLYQRNIIGTLKNLIIE"
     gene            complement(2329..2967)
                     /locus_tag="KNP36_003234"
     CDS             complement(2329..2967)
                     /locus_tag="KNP36_003234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBF0875083.1"
                     /translation="MLIHLVKKDILIVKKYVLLILFIAIGIPLFTLWRLPPFAQILGF
                     VLSIIFSEFMLCQYLLLKESQYSKASVLLCSTPYPRRGLVQSKYVLFAMVFIYCTLVY
                     WIENLLIPQIGTFDLTYILIVLLISSIIYGVYMPIQYKLGYETTKFFFVVIIMASSFV
                     LPLTIAHSNFEIPFIYQYPSMIVNIVLFLLSLIILLASMFISIKIFSNKELV"
     gene            complement(2970..3827)
                     /locus_tag="KNP36_003235"
     CDS             complement(2970..3827)
                     /locus_tag="KNP36_003235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875084.1"
                     /translation="MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTT
                     TIRSILDVVKRDSGKIKIFGKDFDGNEKELKNRIGVVFDDSYFYEELSMAEMKSIIAP
                     SYDNWCEEDYQQNMKRFNLNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGL
                     DPLIRSQILDILTGYMKKCGRGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLL
                     DEHRKVKGDIQFLNDEIKKLFLNLEITGYGFIGITSKINEVQKNMPDILIERPTIEDI
                     MLAYIERRE"
     gene            complement(3829..4203)
                     /locus_tag="KNP36_003236"
     CDS             complement(3829..4203)
                     /locus_tag="KNP36_003236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0875085.1"
                     /translation="MKVLISNTSDKPLYQQIKEQIKEAIFTEELKEGDAMPSIRNFAN
                     DLKVSILTIRRVYEELENEGFLTRQVGIGTFISTGNLEILRDSKRRIVEQKMADMIKD
                     AKALGITQIELQEMMDILYQED"
     gene            complement(5365..6555)
                     /locus_tag="KNP36_003237"
     CDS             complement(5365..6555)
                     /locus_tag="KNP36_003237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HBF0875086.1"
                     /translation="MSDMLLWFSVVLVLFAIGDLIASKTKAKVSAVFVTLLLFLILFV
                     TKAIPADIIEKAGMTAAASWSVPMIMFSMGTMLNVKQFIDEWRTVLTAWLGIVAVIVC
                     VSLCIPLFGKSTVLTSIPVINGALPATTIMTQAALEKGLTLAAATATVVFAIQKFIGT
                     PIASRAALQEANRLLVEYHEAKSKGIDLANVDTDKKEAENTGTKVKQAFCEKYDKYYS
                     TNVCIFFIALFSYLGYELSEIIHVNYSIVCLVVGVIVTRIGIVPKDILEKGKIKGFIN
                     MVVFAAVIPSLAKVSLTDLISLFVPIVGMFAASIIGIFLMMKVLPGWKIIGSKPLAFG
                     VGFCQMLGFPTTYLISNEVCNAVGETEEERAYLMSKIMPKLVVGGMACMISIVVAGLM
                     VPML"
     gene            complement(6571..8526)
                     /locus_tag="KNP36_003238"
     CDS             complement(6571..8526)
                     /locus_tag="KNP36_003238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HBF0875087.1"
                     /translation="MEKIKIESSDIFEYIFPHDISCSPDGKHIAYIISNINEEKDCYE
                     HDLYVMDIKTEKQIHMTQTKDVTSFSWISNTELLFTSKRNKPKAGTTDFYTISIEGGE
                     AKKAFSIPKACSVPVSLGNKLWLLTTKNPTDSKKSEPDRAVEGVDYWTFTDKPFIRDG
                     ENFSQRRRVTLELYQEGENITKAITPKFCEVAGIDVSSDKNRILYTGQIYEDCATPFS
                     GLWEYHIDSGETKELVPQGKYQISLAKYIGKDKVMLQASTLDRSITQNHDIFILDLST
                     SEINMIASPDGMYATLLDVDAVYGGGRSNKVIGDKFIGARICRTMTEFNEFDTKTGNI
                     RIITKVDAFTSFDIYDNTMYTVMLKDYELAEIYSIDMTTGTMKKMTAFSKPYLDTHKV
                     SLPEKLTFVAKNKEEVDGFVIPPIDAKEGEKYPAVLFIHGGPKWAYGYMFTHLKQCVT
                     SKGMYVIYCNPHGGDGYGEKFLEMVERWGYVDYEHLMEFVDTCIEKYPGIDADRLGVA
                     GGSYGGYMTNWIIGHTDRFKAAVSQRGISNLITASLIIDFGDRIMKQTCGDKTPWNHE
                     EVLWNHSPIKYVKNVKTPTLFLHSDRDYRCFMGDTFQMFTALKQLGVDTEMYLFHGDT
                     HGLSRNGRPSNRIARANAIVDWFERYL"
     gene            complement(8543..10609)
                     /locus_tag="KNP36_003239"
     CDS             complement(8543..10609)
                     /locus_tag="KNP36_003239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S9 family peptidase"
                     /protein_id="HBF0875088.1"
                     /translation="MKEVVGSLKKITKERIENTMKKLFTSETFLEYQFISDCQISPDG
                     GYTAFIVKKADIKENGYTSQVYILNNKTGELKQITSINSVGAYAWEDENTILFPALRN
                     EKVKEAVKNGKQCMSYYALSLNGGEAEELFRLPIKGGKLNPIGKGLYAVIDSYDNDRP
                     IVEGLPEEEQQKKINAYNKRHYEHFKEIPYAVNGEGYISRKRKRLYVYDSNINELKAI
                     TAPMFNVVGMKISDGKILYIGQEFKDVKGLKNGVYVFDTNTNTNVCILEKDKYIIKGF
                     ELYQNQVILNLTDALSYGNGENGDFYTIDIDTKEMKLLSGHQHHCIGNTVTSDVKMGA
                     GQTTKVDGEYIYYTSTVDMDCIIERIHIPTGKQEKVTQTGSVDFIDVKDGNIVCVGCL
                     GNGLPEVYTVENGTLCKKTHLNDHILEEYKISVPEYIESKGSSKWEIQGYVYKPVDYE
                     VGKKYPAVLAIHGGPRLTYGPYFMHEIQVFTSAGYFVFFCNPRGSEGRGNAFADIRKQ
                     FGEIDYIDFMEFTDTVLEKYTDIDKTKLAVEGGSYGGFMTNWIIGHTNRFAVACAQRS
                     IANWSGMEGTTDIGYYFCKGQTGASHMENHELQWKQSPLAYVDKCVTPTLFLHGEKDY
                     RCYMQEAFQMFSALKIHGCPTKLCLFEGENHELSRSGRPKQKLQRLVEMLDWFSVYIK
                     KDNIGQ"
BASE COUNT         3604 a         1861 c         1225 g         3944 t
ORIGIN      
        1 atggtttaaa taatcttctt tactttgtat tatgatacat gctttaaata tttttacgca
       61 ctttatatta taatacatgc tttaaataat cttattcgct ttgtattata acacattatt
      121 taaatatttt tactcactct gcattatagt acattattta aatatttttc ttcgctttgc
      181 attatgatac attatttaaa tatttttact caccttgtat tatggtacat tatctaaata
      241 tttttcttca ctctgtatta tgatatataa cttaaatatt ttacctcact ctacaatatt
      301 atatataatt taaatatttt tcttcacttt gtatactaaa gtttatttaa agtattttct
      361 ttcccattat actatgctgt taaatatttt tcaactgaag tattgtagaa ccttaaaatt
      421 actataaaaa actatattct aaaatacttg taatactacg tatcaccctt aacacttaag
      481 tataatttta aagcaaaatt cttattactt atatttaatt ttgattctac atctttagat
      541 ataattttaa gtaatttaag aaattattgt aaatcatata gtactactca ataattaggt
      601 ttttcaatgt tccaattatg tttctttgat ataatccacc atgactaaaa actatcgttt
      661 ctatatcata attacttata tttttaatag catcttttaa ctcttgtttg ttgctgtgca
      721 ttacatcaac aggcttaagt tctccatttt ctacctgtaa caaatctcca gcaataagta
      781 ctttagactc ttttaaataa agacatatgt gacctctagt gtgacctcct gtatgtataa
      841 cttctatttc ctcacctaga ttcaattttt catggttatc taatgacaca tctactttag
      901 tatatgatga tttaaatcca agtcccataa catttagcat actaagcatc ttatcatcaa
      961 ttttatctac catttgttcc aacatataaa gtttaaaagg agtttcttct cctgttatat
     1021 agctgatttc acttttgtat gcatatactt tgatattatt cttagatttt tctcttagat
     1081 aatttatgtt tcctatatgg tctatatcat gatgagtaat tattatattt tttaacttat
     1141 caaagctcgt gttactttta ttaagagcat caattattaa atcaccttga cccggaagac
     1201 ctgtgtcaat aagtgttgca tcatcttctg tgtagattac aggaatatac ataactttat
     1261 cttcaccgaa tacatttgat gaaattttta aaacatctaa tccctttgct aaattcataa
     1321 tttttctcct tataattact taattagagg tcaatttaat taaagaaatt gagaaaatgt
     1381 agattttcct ctagttatat tttattaatt aaaaattatt aatacctagt atatcactta
     1441 agttgaagga ttactcgact tgattttttt gttattttat ggtatagtaa ttaatataga
     1501 agtaagtaat tgcaagcttt gcaattactt ttattttttt ctaataacta ttttattttt
     1561 gataattcgt ataaaattaa aagtaaagta atatggaaaa tatgaatata gaaaaacttt
     1621 aataagaaaa taaattatga ataaataaaa gaaacgcaat actgtatata gatgattatt
     1681 tagaaaaata aaatctcttt taataaaaat aagcttcaaa ataaactttt agttcataaa
     1741 gcttaggagg aactaaattg agtgcaagtg tatctactgt tcaaaataaa tagttcataa
     1801 agcactcttt tttatattaa atcaattata ttttcgtcat ttcagcaatg aaaaagaaac
     1861 ttatctctat tttgagacag cttcttttta ttaacttcct actttttatt agttttctaa
     1921 aattgaaaag ctttatttat aggattcctt agatttatat tttgacgata taatttttta
     1981 aaaacatctt aaaagatggt atacaataca cacaatcata ctcataattg aaaaataatc
     2041 aatggaaaat aaaattactg gatattatct attaaaaaat acaaattgat tcacaagaaa
     2101 catataatct ataatattat gatgttactc tctcgcacca agtaacttta ttttcaagta
     2161 accttttaaa ttcataccat ctaacttcac tcaataaaaa tggcaatata aatatgtact
     2221 ctatttttta cttttaaata tctgacaagc tttatatact attggaagta aaatacaaag
     2281 taaaacagcc caatctggta aatgtggcat ataaaagtcc cccttacctt atacaagctc
     2341 cttattacta aaaattttaa tagaaataaa cattgaagct aacagtataa ttaaacttaa
     2401 aaggaacaat acaatattca ctatcatgga tggatactga tatataaatg gaatttcaaa
     2461 attgctgtga gctatagtta atggtaatac aaatgatgaa gccatgatta tcaccacgaa
     2521 aaagaatttt gttgtttcat atcctaattt atattgaata ggcatataaa ctccataaat
     2581 aatagaactt attaataaaa caatcaaaat atatgttaag tcaaaagttc ctatttgtgg
     2641 aataagtaaa ttttcaatcc agtaaactaa tgtacaatag ataaatacca ttgcaaataa
     2701 aacatactta gattgaacta agccacgtct aggataagga gttgaacaaa gtaatacaga
     2761 tgcttttgaa tattgactct cctttaataa tagatactgg cacagcataa attctgaaaa
     2821 tataatggat agtacaaatc ccaatatttg tgcaaatgga ggtaaacgcc acaatgtaaa
     2881 taatgggatt cctattgcaa taaacaatat caacaataca tattttttta caatcagaat
     2941 atctttttta actaaatgaa tcaacataat tactctctcc tttcaatata tgcaagcata
     3001 atatcttcaa ttgtaggacg ctctattaaa atatctggca tatttttttg cacttcatta
     3061 atttttgagg taatccctat aaaaccataa cctgtaattt ctaaatttaa aaataatttt
     3121 ttgatttcat catttagaaa ttgaatatcc ccttttactt ttctatgttc gtccaataga
     3181 gtatcttttt cacgctctaa tataatacgt ccattgtcaa tcataacaat catatctgct
     3241 attttgtcta aatcagatgt tatatgagtg gaaaagaaaa caccacgacc acattttttc
     3301 atatatcctg ttagtatgtc aagtatctga ctacggatta gtgggtctaa accacttgta
     3361 ggttcatcca taattaaaaa ctcagcttta tgcgataatg ctaatgctaa tgcaaatttc
     3421 attttcattc cttttgaaag tgtatcaatc ttttgttttg ggttaagatt aaaacgcttc
     3481 atattttgtt gataatcttc ttcacaccaa ttatcatatg aaggtgcaat aatacttttc
     3541 atttctgcca ttgacaactc ctcatagaaa tatgaatcat caaatacaac tccaattcga
     3601 ttttttaatt ccttctcatt tccatcgaaa tctttaccaa agatttttat ttttccacta
     3661 tcacgcttta cgacatccaa tatcgaacgg attgttgttg tttttcctgc tccattaaca
     3721 cctataaatc cagttataca atcttctggt aatgcaaagc ttatattaga taatgaaaaa
     3781 tcggtataag tcttatttaa gttataaact tctaaaatat tttccatatt aatcctcctg
     3841 atatagaata tccatcattt cttgtaactc tatctgtgta attcctagtg cttttgcatc
     3901 cttaatcata tctgccattt tttgttcaac tatacgtctc tttgagtctc ttagtatttc
     3961 taaatttcca gttgaaataa atgttcctat tccaacttgg cgtgtaagaa agccttcatt
     4021 ttcaagttct tcatacactc gtctaatagt caaaatacta acttttaaat cattagcaaa
     4081 atttcttatg gatggcattg catccccttc tttcagttct tcagtaaata ttgcttcttt
     4141 aatttgctct ttaatttgtt ggtataatgg cttatctgat gtgttagaaa tgagcacttt
     4201 cattttttat cacccccttt ttatcatttt cagtgtgatg ttgttatata cacactatac
     4261 acttagagca cttttttgtc aatataaaag atgtaaaata ttactatgac aaaataaata
     4321 tgaatgaaat attagagatt gttgatagct ataaacactt tttaaaacca cataagatag
     4381 aatgtattaa atatttatta aaagtaagaa ttgaatatct aaaaaaaaga ggaatcctgt
     4441 atgaatgatt tgtttgatga taaattaagt tataaactat ttataaaaaa cataaaggaa
     4501 taaatccatt tctaattaca aacatactaa aaaatttaga tagtaataaa tagatagtaa
     4561 taaatagata gtaataaatg ggatgaattt ataagaattt ggatagagga aagagttatt
     4621 caagagtgta gactagaggt aaactctata ttaaaaaaat ttaaatttgg atattatgat
     4681 gcatggaata tttgcagaag taaccttgct ataagtatag aagatttttt tgattacaaa
     4741 agataatact ctaaaatgtg aggatttcaa cattcaatac tgtactttaa ataatatcac
     4801 tgcaaaatac catccacctt ttaccataat tgaataccct aattatttta aaaaagaaaa
     4861 cattagaaac agaaaacctt ggatatataa aataaaaaat actaacttct aaaacacgga
     4921 tactctttga taaataaaac aaaaaataat tttaataatt aaaattggct atctcaaact
     4981 agagataagt ctctttctca cttttaaaac gttgaaaata tattcgattt cgtacaaaaa
     5041 agagtgcctt agaactaaaa agttcacttt gtggcactcc cttttttctc ctctttttaa
     5101 ttttttataa aaattcttca aaaatattat taaataccct atattataca taaatcaaat
     5161 taaagttgca ttttagcaaa taaaaacaaa ttataactat tagcatagca aataaaaaat
     5221 ctgctctctt ataaaatcaa attataatta taaaaagaaa atattcttat aacaaattag
     5281 ctaatataaa attattttat aaattaatac tactttttag cttctcctat aaattaatac
     5341 cactttttta actttgaaac ctatctacaa cattggtacc ataagaccag ctaccacaat
     5401 agaaatcata caagccatac caccaactac cagcttaggc ataatcttag acatcaaata
     5461 tgctctttct tcttccgttt ctccaacagc attacacact tcatttgaaa ttaaatatgt
     5521 agttgggaat cccaacatct gacaaaaccc tactccaaaa gcaagaggtt tagaaccgat
     5581 aattttccaa cctggtaaca ccttcatcat aaggaatata ccaatgatag aagctgcaaa
     5641 catacccaca attggtacaa aaagactaat taaatctgtc aaagaaactt ttgctaaaga
     5701 aggaataaca gctgcaaaca caaccatgtt gataaatccc ttgatttttc ctttttccaa
     5761 aatgtctttt ggcacaatac caatacgtgt tacaataaca ccaacaacaa gacatacaat
     5821 agaataattt acatgaataa tctctgaaag ttcataccct agataagaga ataatgctat
     5881 aaaaaatata caaacatttg tagaataata tttatcgtat ttttcacaga aagcttgttt
     5941 tacttttgtg cctgtattct ctgcttcttt cttatcagta tcaacatttg ctaaatcaat
     6001 gccttttgat tttgcttcat gatattctac taaaagacgg tttgcctctt gtaacgctgc
     6061 tcttgaagct attggtgtac caataaactt ctgaattgca aatacaactg ttgctgtagc
     6121 tgctgcaagt gtcagtcctt tttctagtgc tgcttgtgtc ataatagtag tagcaggtaa
     6181 agctccattt ataactggta tgcttgtcaa tactgttgat tttccaaaca aaggaataca
     6241 taatgagaca cagactataa ctgctacaat tccaagccat gctgtcaata ctgttctcca
     6301 ttcgtctata aattgtttaa cattcaacat tgttcccata ctaaacataa tcattggaac
     6361 actccaacta gctgctgcgg tcatacctgc tttttcaata atatcagctg gtattgcttt
     6421 tgtgacaaat agaatcaaaa ataaaagtag tgtaacaaat acagctgata cttttgcttt
     6481 tgttttgctt gcaattaaat ccccaatagc aaataaaact aatacgacac taaaccataa
     6541 taacatatca ctcatagaat aaccccctta ttataaatat ctttcaaacc aatctacaat
     6601 agcatttgct cttgcaattc tattagatgg tcttccattt ctagacaatc catgtgtatc
     6661 tccgtggaac aaatacattt ctgtatctac accaagctgt tttaatgctg taaacatttg
     6721 gaaagtatcc cccataaaac atctataatc cctatcacta tgtaagaaca atgttggtgt
     6781 cttaacattt ttcacatatt taataggtga atgattccaa agaacctcct catgattcca
     6841 aggcgtctta tctccacaag tctgcttcat aattctatcc ccaaagtcaa taattaaaga
     6901 agctgtaatc aagttactaa tacctctttg agaaactgct gctttgaaac ggtctgtatg
     6961 accaattatc cagtttgtca tataaccacc gtaacttccc cctgcaaccc ctaagcggtc
     7021 tgcatcaatc ccaggatatt tttcaataca agtatctaca aattccataa gatgctcata
     7081 gtcaacatac ccccatcttt ctaccatttc taagaatttt tcaccataac cgtcaccacc
     7141 atgagggtta caataaatca catacattcc ctttgatgtt acacactgct tcaagtgtgt
     7201 aaacatatag ccatatgccc atttaggccc accatgaatg aacaatacag caggatattt
     7261 ttcgccttct ttagcatcta taggtggtat aacaaaacca tcaacttctt ctttattttt
     7321 tgctacaaac gtcaattttt caggtaatga aaccttatga gtatctaaat atggtttaga
     7381 aaaagcagtc atttttttca ttgtacctgt agtcatatca atgctatata tttctgctaa
     7441 ctcataatct ttcaacatta ctgtgtacat ggtgttgtcg taaatatcaa aagatgtaaa
     7501 agcatctact tttgtgatga tacgtatatt acctgtcttt gtatcaaact cattaaattc
     7561 tgtcatagtt ctgcaaattc ttgcaccaat aaatttatct cctataactt tattactacg
     7621 tccaccacca tatactgcat ctacatccag taatgtagca tacataccat ctggactagc
     7681 aatcatattt atttcactag tactcaaatc aagtataaaa atatcatgat tctgtgtaat
     7741 agaacggtct aatgttgaag cttgcaacat tactttatct ttgccaatat attttgccaa
     7801 acttatttgg tactttcctt gtggtacaag ttctttggtt tcaccactgt ctatatgata
     7861 ctcccaaagt ccagaaaaag gagttgcaca atcttcataa atctgaccag tatataaaat
     7921 tctgttttta tccgaagaaa catctatacc tgctacttca caaaattttg gtgtaatggc
     7981 ttttgttata ttttcacctt cttgatataa ttctaatgtt acacgtcttc tttgagaaaa
     8041 attttctcca tctcttataa aaggtttatc tgtaaatgtc caataatcta caccctctac
     8101 tgccctatct ggttctgatt ttttagaatc cgttggattt tttgttgtca gtaaccacaa
     8161 tttatttcca agtgatacag gtacgctaca agcttttgga atagaaaatg ctttttttgc
     8221 ttctcctcct tctatagaaa tagtgtaaaa atctgttgta cctgcttttg gcttatttct
     8281 tttagatgta aaaagtagtt ctgtattaga aatccaacta aatgatgtta catcttttgt
     8341 ttgagtcata tgtatttgtt tttctgtttt gatgtccatc acatataagt catgttcata
     8401 gcagtctttt tcctcgttga tatttgatat aatataagca atatgctttc catcaggtga
     8461 acaagaaata tcatgaggga atatatattc aaaaatatct gaactttcaa tctttatttt
     8521 ttccattttt atattctcct ttctactgtc ctatgttatc tttttttata tataccgaaa
     8581 accaatctag catttcaact aatctttgta gcttttgttt tggtctacca gaacgagaca
     8641 gttcatggtt ttctccttca aatagacaaa gttttgtagg acacccatga attttcaatg
     8701 ctgaaaacat ctggaatgct tcttgcatat agcatctata gtctttttca ccatgtaaaa
     8761 ataaagtcgg tgtaacacat ttatcaacat aagcaagagg tgactgtttc cattgaagct
     8821 cgtggttttc catatgagaa gcacctgttt gtcctttgca gaaataataa ccaatgtctg
     8881 ttgtaccctc catgccactc cagtttgcaa tagaacgctg agcacaagca acagcaaaac
     8941 ggtttgtatg accaattatc caattcgtca taaatccacc ataacttcca ccttcaacag
     9001 ccaattttgt tttatcaatg tctgtatatt tttcaagtac agtatctgta aattccataa
     9061 aatctatata atcaatttct ccaaactgtt tcctaatatc tgcaaaagca ttgccacgac
     9121 cttcagaccc ccttgggtta cagaagaata caaagtaacc tgcacttgta aatacctgta
     9181 tctcatgcat aaaatatggt ccatatgtca atcttggtcc tccatgaatc gccaatacag
     9241 ctggatattt tttccccacc tcataatcta ctggtttata tacgtatcct tgtatttccc
     9301 atttagaact tccttttgac tctatgtatt ctggcacaga aattttatat tcctctaaaa
     9361 tatggtcatt taaatgtgtt ttcttacaca atgttccatt ctctactgta taaacttctg
     9421 gtaatccatt tcctaaacaa cccacacata caatattgcc atcttttaca tctataaaat
     9481 caactgaacc tgtctgtgtt actttttcct gttttcctgt tggaatatgt attctttcaa
     9541 taatgcagtc catatctact gtagaagtgt aataaatata ttctccatct acctttgttg
     9601 tctgaccagc acccatttta acatcagatg ttactgtatt tccaatacaa tgatgttgat
     9661 gccctgaaag aagtttcatt tctttcgtat caatatcaat agtataaaaa tctccatttt
     9721 ctccatttcc ataagataaa gcatcagtta ggtttagtat cacttgattt tgatataatt
     9781 caaaaccttt tataatatac ttatcttttt ctaatataca gacatttgtg tttgtgtttg
     9841 tatcaaatac atagacccca tttttcaaac cttttacatc tttaaattct tgccctatat
     9901 ataagatttt tccatcactt attttcatac ctacaacatt aaacataggt gctgtaattg
     9961 ccttcaactc atttatatta ctatcgtata catataggcg ttttcttttt ctgctaatat
    10021 atccctcccc attgacagca taaggaattt ctttgaaatg ttcataatgt cttttgttat
    10081 aagcatttat ttttttctgt tgttcttctt ctggcaatcc ctctacaata ggtcggtcat
    10141 tgtcataaga atcaataact gcatacaaac cttttcctat aggattcaat ttaccacctt
    10201 tgatagggag tctaaaaagt tcttctgctt ctccaccatt taaagataaa gcatagtaac
    10261 tcatgcattg cttaccgttt ttgacagctt cttttacttt ttcatttcgc aaagcaggga
    10321 acaagatagt attttcatct tcccaggcat atgctccaac agagtttata gacgttattt
    10381 gttttaattc gccagtttta ttgtttaata tataaacttg gcttgtgtaa ccattctctt
    10441 tgatatcagc tttttttaca ataaatgctg tatatcctcc atctggtgat atttggcaat
    10501 cacttataaa ttgatattcc aaaaatgttt cactcgtaaa tagctttttc atagtatttt
    10561 ctatcctttc tttagtaatt tttttcaaac tccctaccac ctctttcatt ttttatttta
    10621 aatttaaaat aaaa
//
LOCUS       DAEHWM010000113        10552 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.116, whole genome shotgun sequence.
ACCESSION   DAEHWM010000113 DAEHWM010000000
VERSION     DAEHWM010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10552)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10552)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10552
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.116"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            108..506
                     /locus_tag="KNP36_003240"
     CDS             108..506
                     /locus_tag="KNP36_003240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HBF0875089.1"
                     /translation="MIKKIEHVVITNNNIENYINFYKKFGFSSKEMSKNYKLNARNVK
                     INLNIKGYKFLPYVKNSKASRDNLCFKINTNIDEPKKYLEQNEIQIKRGIVECTGVFG
                     NMKSIYLKKTNGNLIELSNHRITESKPWKI"
     gene            494..1432
                     /locus_tag="KNP36_003241"
     CDS             494..1432
                     /locus_tag="KNP36_003241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AEC family transporter"
                     /protein_id="HBF0875090.1"
                     /translation="MENLILSINVVLPLFLTMSLGYVLKKLGLFDTHTLNKMNNVCFK
                     SFLPLLLFFNIYNTDLDGSLNFKLMAVAVIIIFSIFLILVFIIPKIEKDNKTRGALIQ
                     GVFRSNFVIFGIPVTISLFGDKSIGVTSLLIAVIVPMFNVLSVVILEIFRGGKVNIKH
                     MIKSVLTNPLIIASFIGLTMLILNINIPTFLHKTIGDISKIATPLSLIILGGSFSFSA
                     IKGHIKPIILGVCGKLILVPAIFLPISIFLGFRNVELASLMIMLSAPTAVSSFTMAQQ
                     MDSDSELAGQIVVFTSGFSIITVFLIIFILKQNNLI"
     gene            complement(1816..2040)
                     /gene="secG"
                     /locus_tag="KNP36_003242"
     CDS             complement(1816..2040)
                     /gene="secG"
                     /locus_tag="KNP36_003242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HBF0875091.1"
                     /translation="MSNILMGVQVVLGILLVISIMPQDSKNALPSEFGGEGSQAYFKP
                     KGKQAFLARVTKITAVLFFINALALLIVKK"
     gene            complement(2633..3925)
                     /gene="eno"
                     /locus_tag="KNP36_003243"
     CDS             complement(2633..3925)
                     /gene="eno"
                     /locus_tag="KNP36_003243"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HBF0875092.1"
                     /translation="MSVIELVYAREVLDSRGNPTVEVEVVLEDGAMGRAIVPSGASTG
                     AFEAVELRDGDKGRYLGKGVETAVANVNEIIAPEIEGMDAFDQPAIDAIMIELDGTPN
                     KGKLGANAILGVSMAVARAAADEIGLPLFQYLGGVNAKQLPVPMMNILNGGEHADNNV
                     DVQEFMILPVGACCFKEGLRMGAEVFHSLKKVLGEKGLACGVGDEGGFAPNLGSNREA
                     LELIVEAITKAGYKPGEDVMLGLDVAATEMYNKETKKYVLAGEGKELTAAEMVALYED
                     WSNNFPIITIEDGLDEEDWDGWKLLTEKLGNKLQLVGDDLFVTNTERLEKGIENGVAN
                     SILVKVNQIGTITETLDAIEMAKRAGYTAVISHRSGETEDSTIADLAVAVNAGQIKTG
                     APSRTDRVAKYNQLLRIEEMVGEQARYCGLKSFYNLKK"
     gene            complement(4513..6045)
                     /locus_tag="KNP36_003244"
     CDS             complement(4513..6045)
                     /locus_tag="KNP36_003244"
                     /EC_number="5.4.2.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003228330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-independent
                     phosphoglycerate mutase"
                     /protein_id="HBF0875093.1"
                     /translation="MMKKPVALIIMDGFGYNKDVKGNAIAESKTPNLDRIKKEYPNTL
                     INASGLDVGLPDGQMGNSEVGHTNIGAGRIVYQDLTRITKSIKDGDFFTNKVLCEAMD
                     NAKENSLHVMGLLSDGGVHSHIDHLKAIIKMAKDKGVQKVYVHAFTDGRDTDPQSALE
                     YAKEVQASMDEIGVGEFATVSGRYYAMDRDKRWERVELAYNAMVRGIGEKANSIEEAI
                     QNSYDDGKNDEFIMPTVIMKDDKPVGSIKENDSIIFFNFRPDRARQITRALVCEEFDG
                     FKREDIKNFFVCLTEYDITIENVHIAFGPQSLANTLGEYLAKNGKTQLRAAETEKYAH
                     VTFFFNGGVEEPNKGEERLLIPSPKVATYDLKPEMSAYELTDKALDKLGEDKFDFIVL
                     NFANPDMVGHTGSIEAAIKAVETVDTCVGRLIDKIVELGGSAIITADHGNAEYMLDPE
                     TGKTVTAHSINPVPFIVVGQEYESAKLLDGGRLSDIAPTILDMMKLEKPEEMTGHSLI
                     SK"
     gene            complement(6054..6797)
                     /locus_tag="KNP36_003245"
     CDS             complement(6054..6797)
                     /locus_tag="KNP36_003245"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HBF0875094.1"
                     /translation="MRKPIIAGNWKMHKTIKEALEFVNEVKDKVNSDKVEAVICAPFT
                     LLKDLKEATKGTNIKIGAQNMHFEEKGAFTGEVSPLMLKEIDMDYVVIGHSERRQYFN
                     ETDETVNKKVLKALEVGIDPILCVGETLEQREAGKTKDVCKVQVEKALENVLKDDLAK
                     VVVAYEPIWAIGTGKTATAEDANDVISYIREVIKGLYGELANEVRIQYGGSVKPSNVA
                     EIMGQSDIDGALVGGASLASNDYLDLVNF"
     gene            complement(6823..8025)
                     /locus_tag="KNP36_003246"
     CDS             complement(6823..8025)
                     /locus_tag="KNP36_003246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HBF0875095.1"
                     /translation="MSMLNKKTIEDIDVCGKKVLVRCDFNVPLQDGVITDENRLNGAL
                     PTIQYLISKGAKVILCSHLGKPKGEAKPELSLAPVAKRLSEMLGKEVVFAADDNVVGE
                     NAKKATEKMENGDVVLLENTRYRKEETKNEENFSKELASLAEIFVNDAFGTAHRAHCS
                     TVGAGEFLQERVCGYLIQKELKFLGEAVANPVRPFTAILGGAKVSDKLAVINELLEKV
                     DNLIIGGGMAYTFLKAQGYEVGTSLLEIDKVEYAKEMMEKAKNKGVNLLLPVDVVMAD
                     HFAPDATPIVTEDANVKEDYMGLDMGPKTIANFVKTIKESKTVVWNGPMGVFEFENFA
                     NGTLSVARAMAELTDATTVIGGGDSAAAVNQLGFGDKMTHVSTGGGASLEFLEGKELP
                     GIAALDNK"
     gene            complement(8247..9254)
                     /gene="gap"
                     /locus_tag="KNP36_003247"
     CDS             complement(8247..9254)
                     /gene="gap"
                     /locus_tag="KNP36_003247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HBF0875096.1"
                     /translation="MVKVAINGFGRIGRLALRKMMEQQDKFEVVAINDLTDAKMLAHL
                     FKYDTAQGRFNGEIEVKEGAFVVNGKEIKVTAERNPADLPWAELGVDIVLECTGFFTS
                     KDKAEAHIQAGAKKVVISAPATGDLKTIVFNTNSDILDGSETVISGASCTTNCLAPMA
                     KVLNDKYGIEKGLMTTIHAYTNDQNTLDGPHPKGDLRRARAAAGNIVPNTTGAAKAIG
                     LVIPSLKGKLDGAAQRVPVVTGSITELVCTLGKNVTVEEINAAMKEASNESFGYTEEM
                     LVSSDIIGISYGSLFDATQTKVMEVDGKQLVKVVSWYDNEMSYTSQLIRTLGYFAQLA
                     K"
     gene            complement(9314..10336)
                     /locus_tag="KNP36_003248"
     CDS             complement(9314..10336)
                     /locus_tag="KNP36_003248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBF0875097.1"
                     /translation="MKNLLEIQKKLIPQAIELMERRYSILRQISLSEPIGRRTLSNVL
                     EISERIIRSETEFLKEQGLIDVAVSGMTITKEGSDLLDKLKDIMSDIMGLSKLQDRVR
                     EKLGIKRVILVPGSCDENGSLLKDVTRYGCEYFLGILKDGDIVSITGGSTMLEFSNVI
                     KTDKRYPNSTIVPARGSMGTDVEMQSNNIVASISKKLHSNCKLLHIPDELDESAMKTL
                     SQVPEIKTTLEYIKRTDILVFSIGRADVMAKRRKLPEDKVDEILSKNAVGEAFGYYFN
                     KDGEIVYKLNTVGIDLETVKQVKETIAIFAGTEKVEALLAISNMHKNMVLVTDEESAY
                     KILSLL"
BASE COUNT         3269 a         1924 c         1196 g         4163 t
ORIGIN      
        1 atcaatctat ataaaattta ataatttata taaatatcat caatctatat aaaatttaat
       61 aacttatata aatttaacta atttatataa aatcttaagg agttgccatg ataaaaaaaa
      121 tagaacatgt ggtcattact aataataata tagaaaatta tatcaatttt tataaaaaat
      181 ttggtttttc atctaaagaa atgagcaaaa attataaact taatgctaga aatgttaaga
      241 taaatcttaa cataaaaggt tataaatttt taccttatgt taaaaattca aaagcaagta
      301 gagataactt atgttttaaa ataaacacaa atattgatga gccaaaaaaa tacttagaac
      361 aaaatgagat tcaaattaag agaggaattg tagaatgtac aggtgtcttt ggtaatatga
      421 aatctattta tttgaaaaaa actaatggaa atttaattga attatcaaat catagaatca
      481 cggagagtaa accttggaaa atttaatcct atcaataaat gttgttcttc ctttgtttct
      541 cacaatgtca cttggatatg ttctaaaaaa attaggtcta tttgatactc atactttaaa
      601 taaaatgaat aatgtttgct tcaagtcttt cttgccatta ttattatttt ttaatatata
      661 caatacagat ttagatggtt ctcttaattt taagcttatg gctgtagctg ttataattat
      721 tttttcaatc ttcttaatct tagtctttat tattcctaaa attgaaaaag ataataagac
      781 aaggggtgca ttaatacaag gtgtatttcg tagcaatttc gttatatttg gtattcctgt
      841 gacaatttca ctatttggcg ataagagtat tggagtcaca tctttattaa ttgcagttat
      901 tgtacctatg tttaatgtat tatctgttgt aattcttgaa atttttagag gtggcaaagt
      961 aaatataaaa catatgatta aaagcgtctt aacaaatcca ctcataatcg cctcttttat
     1021 aggattgaca atgctaattt taaatattaa tatacctaca tttttacaca aaactattgg
     1081 tgatatttct aaaatagcta ctcctttatc acttataatt ctaggcggct cttttagttt
     1141 ttctgctata aaggggcata taaaacccat tatattgggc gtatgtggaa aacttatact
     1201 tgtacctgct atatttttac caattagcat ttttcttgga tttagaaatg tagaattagc
     1261 ttcacttatg ataatgttat ctgctccaac tgcagtttct tcatttacaa tggcacaaca
     1321 gatggattct gacagtgaat tagctggaca aattgtagta tttacttctg gattttctat
     1381 aattacagta tttttaataa tatttatttt aaagcagaat aatcttattt aatgatattt
     1441 gataacacaa attggtatta taagaaacat atataaaact gatttaatcg cgtaaaaaca
     1501 tattattata ctatttttac tatataatat aactttgtgt atattatctc attaaacatg
     1561 gtgaaagtag tgttgctata tattttttag tttgaagaaa atatataaat acaaacaata
     1621 tataaataca aataataaac gccaccaaat agtcaatcta taaaataaaa actggactaa
     1681 tcatataaaa tcattagtcc agcttttatt ttacgtactt tttatgttga tgtactttta
     1741 ttaaaaacta aatttaattt ttaaatgtct agcaaatgca ctaattaaat aatggccagt
     1801 tattcaacaa tatcactact tcttaactat aagtaatgcc aatgcattta taaaaaataa
     1861 tactgctgtt atctttgtaa ctctagcaag aaatgcttgt tttccttttg gtttaaagta
     1921 agcttgactt ccttctccac caaattctga aggtaaagca ttcttagaat cttgaggcat
     1981 tatgctaatt actagtaaaa tccctagtac tacttgcaca cccattaaaa tgttgctcat
     2041 tcttgcccct cctatctgtt tattacttaa atttcattac tctttagtgt atcacaataa
     2101 tatagccatt tcaagactat tatgctataa ataacataca aaaaaatata ttgttactat
     2161 aatatattac tatattctca atataaaaat gaataaaact tagaagagaa aactatttaa
     2221 attaatacat aaattaacac ttaaaataat ctactctcat tgtatatatt ataaatagcc
     2281 accaaaataa aacaatcatt ttaaaatatt gatataactt ttaatttcaa cataatttaa
     2341 aataaataat ccacatttag caataatact tcaatgacaa ttatgattaa atcaaaatat
     2401 gtcttcactt ttatttttta ataaaaacct cctatgcaat tagataaaaa tgagatagaa
     2461 acatttattc atattttttc tgaatctatg aataaaatta agtaataaaa tataaaaaag
     2521 gataagtgaa ttgaaaaatc aattaacact tatctctttt atatcttata agatgagctt
     2581 aaatatctta tattctctct tcattaatct tttttagtaa ccattttaat aactattttt
     2641 ttaagttata gaaagatttt aatccacaat atctagcttg ctctccaacc atttcttcta
     2701 ttcttaataa ttggttgtac ttagcaactc tatcagttct tgatggagca ccagttttta
     2761 tttgaccagc atttactgca acagctaaat ctgctatagt agaatcttca gtttctcctg
     2821 atctgtgaga tataacagca gtatatcctg ctctcttagc catttctata gcatctaaag
     2881 tttcagttat tgtacctatt tgattaactt taactaatat agagttagct actccatttt
     2941 caattccttt ttctaatctc tctgtgttag taacaaataa gtcgtcacca actaattgta
     3001 atttatttcc taatttttca gttaataatt tccatccatc ccaatcttct tcgtctaaac
     3061 catcttctat agttattatt gggaagttgt ttgaccaatc ttcatataaa gcaaccattt
     3121 cagcagcagt taactctttt ccttctcctg ctaaaacgta ttttttagtt tctttgttgt
     3181 acatttctgt agcagcaacg tcaagaccta acataacgtc ttcacctggc ttatatccag
     3241 cttttgttat agcttcaact attaattcta aagcttctct gtttgaacct aagtttggag
     3301 caaatccacc ttcgtcacct acaccacaag ctaatccttt ttctcctaaa actttcttta
     3361 acgaatggaa tacttctgct cccattctta aaccttcttt gaaacaacaa gctcctactg
     3421 gtaatatcat aaattcttga acatcaacgt tgttatcagc atgctctcca ccgtttaata
     3481 tgttcatcat tggaacaggt aattgtttag catttactcc acctaggtat tggaataatg
     3541 gtaaacctat ttcatcagca gctgctctag ctactgccat tgaaacacct aatatagcat
     3601 tagctcctaa tttacctttg tttggagttc catctaattc tatcatgatt gcatctatag
     3661 ctggttggtc aaatgcatcc attccttcta tttcaggtgc tattatttca tttacgttag
     3721 caacagctgt ttctacacct tttcctaagt atcttccctt atctccatct cttaattcaa
     3781 cagcttcaaa agctcctgta gatgctcctg atggaactat tgctcttccc attgctccat
     3841 cttctaatac tacttcaact tctacagttg gatttcctct tgagtctaat acttctctag
     3901 catatactaa ttcaataact gacatttgta tatctccctt cgattttcta ttagttaaat
     3961 tttcatttac tgtaaacatc cgtctactat tttaatctac tttctatatt atagtacata
     4021 aagttgcttt tgaaaattag gtacaaattt atttgatggg taaatttgta aaagttccta
     4081 tttttatttt attttttata atattttaat ttatataata taaaaaaact tgtctaaaat
     4141 ccaaaaccaa tcttaaatac acaaatatta taactagatt taaaacatta aacataaaat
     4201 gtacaactaa tgattctaaa atttttgctt atataatata tattaattat tattatttat
     4261 attgttattg tctatcttgt tattatttat atcattattt acattattat ctatattgta
     4321 attttttatt ttataaattg tctatcttgt aaattttata aaatatatct tcatctacac
     4381 cttacaatat ccagaactta caaaatttaa accttatgtc ataaagtcta aactttacaa
     4441 aataaaccta aactgcatta tttttaaatt tatattgtag tttatatatt attatctact
     4501 tatcagaatc gactattttg aaataagtga atgaccagtc atttcttctg gcttttctaa
     4561 cttcatcata tctaaaatag taggtgctat atcagataat cttcctccat ccaataattt
     4621 tgcactttca tattcttgac caactacaat aaatggtact ggattaatag agtgagccgt
     4681 tacagttttt cctgtttctg ggtctaacat atattcagca tttccgtggt cagcagttat
     4741 tattgcactt ccacctaact ctactatttt atctatcaat cttcctacac aagtatctac
     4801 agtttcaaca gcctttatag ccgcttctat acttcctgtg tgacctacca tatcaggatt
     4861 tgcaaagttt aatactataa agtcaaactt atcttctcct aatttatcta aagctttatc
     4921 tgtcaattca tatgctgaca tttctggttt taaatcataa gttgcaacct ttggagaagg
     4981 tatcaatagt ctttcttcac ctttatttgg ctcttctact ccaccattga agaagaaagt
     5041 tacatgtgca tacttttcag tttcagcagc tctaagttga gtttttccat ttttagctag
     5101 atactcacct agagtgttgg ctaaagattg aggtccaaat gctatatgca cattctctat
     5161 agttatatcg tactctgtta agcatacaaa gaagttttta atatcttctc ttttaaatcc
     5221 atcaaactct tcacaaacta aagctctagt tatttgtcta gctctatctg gtctaaagtt
     5281 gaagaatata attgaatcat tttcctttat acttccaact ggtttatcat ctttcataat
     5341 aactgttggc attataaact catcattttt tccatcatca taagagtttt gaatagcttc
     5401 ctcaatagaa tttgcttttt caccaatacc tctaaccatg gcattgtatg caagttctac
     5461 tctttcccat ctcttatctc tatccatagc gtagtatcta ccagaaactg tagcaaattc
     5521 acctactcca atttcatcca tactagcttg tacttctttg gcatattcta atgcactttg
     5581 agggtcagta tctctaccat cagtaaatgc gtgaacatac accttttgta cgcctttatc
     5641 ttttgccatt ttgattatag ccttaagatg gtctatatgt gaatgtactc ctccatcaga
     5701 caaaagtccc attacatgaa gagagttttc ttttgcatta tccattgctt cacataaaac
     5761 tttattagta aaaaagtcac catcttttat agattttgtt attctagtta aatcttgata
     5821 tactattcta cctgcaccta tgttagtgtg tccaacttct gaatttccca tttgaccatc
     5881 aggtagacca acatcaagac cactagcatt tatcaatgtg tttggatact ctttttttat
     5941 tctatctaaa ttaggagttt tggactcagc aattgcattt cccttaacat ccttattgta
     6001 tccaaacccg tccataataa ttaaagcaac tggttttttc atcatttcac tccttagaaa
     6061 ttaacaaggt ctaggtaatc attactagct aaactagctc cacctactaa agctccatct
     6121 atatcacttt gacccattat ttcggctaca tttgaaggtt taacacttcc accgtattgt
     6181 attctaactt cattagctaa ttctccatat aatcctttta taacttctct tatataagat
     6241 ataacgtcat tagcatcttc agcagttgca gttttaccag ttccaatagc ccagattggc
     6301 tcatatgcaa caactacttt tgctaaatca tctttaagaa cattttctaa agctttttca
     6361 acttgaactt tacaaacatc tttagttttt ccagcttctc tttgttctaa agtttctcca
     6421 acacataata ttgggtctat tcctacttct aatgctttta aaactttctt gtttacagtt
     6481 tcatcagttt cattgaagta ttgtcttctt tctgaatgtc ctattacaac atagtccata
     6541 tctatttctt ttaacataag aggtgaaact tctcctgtaa atgctccttt ttcttcaaag
     6601 tgcatatttt gagcacctat ctttatattt gtacccttag tagcttcttt taaatccttt
     6661 aataaagtaa atggtgcaca tataacagct tctactttat cagaatttac tttatcttta
     6721 acttcattta caaattctaa agcttctttt attgttttat gcattttcca gtttcctgca
     6781 attataggtt ttctcatttt acaatctcct ctatatatta gtttatttat tatctaatgc
     6841 tgcaatacct ggtaattctt taccttctaa aaattctagt gatgctcctc cacctgttga
     6901 tacgtgagtc atcttgtcac caaatcctaa ttgattaact gctgctgcac tatctccacc
     6961 gccaattaca gtagttgcat cagtcaactc tgccatagct ctagctactg ataatgtacc
     7021 atttgcaaag ttttcaaatt caaatactcc cattggccca ttccatacta cagtttttga
     7081 ttcttttata gtttttacaa agtttgctat agtcttaggt cccatatcta gtcccatgta
     7141 atcttctttt acattagcat cttctgttac tattggagta gcatctggtg caaagtggtc
     7201 tgccataaca acgtctactg gtaataataa gttaacaccc ttattcttag ctttttccat
     7261 catttcttta gcatattcaa ctttatctat ttcaagtaaa gaagttccta cttcataacc
     7321 ctgagctttt aagaatgtat aagccattcc tccacctatt attagattat caactttttc
     7381 taataattcg tttataacag ctaatttatc agaaacttta gctcctccaa gtatagctgt
     7441 aaatggtctt acagggtttg caacagcttc tcctaagaat tttaattctt tttgaattaa
     7501 gtatccacaa actctctctt gtaaaaactc gcctgcacca actgttgagc aatgtgctct
     7561 atgagcagtt ccaaatgcat catttacaaa tatttcagca agtgatgcta gttctttaga
     7621 gaaattctct tcgtttttag tttcttcttt tctatatcta gtattttcta ataatactac
     7681 atctccgttt tccatttttt cagttgcttt ctttgcattt tctcctacaa cattatcgtc
     7741 tgctgcaaat acaacttctt ttcctaacat ctcagataat ctctttgcta ctggtgctaa
     7801 agataattct ggtttagctt ctccttttgg ctttcctaag tgagagcata atataacttt
     7861 tgccccttta gaaattaaat attgaatagt tggtaaagct ccgttcaatc tattttcatc
     7921 agtaattaca ccatcttgta atggcacatt aaagtcacat cttactaata ctttttttcc
     7981 gcacacatca atatcttcta tagttttttt gttaagcatt gacataaata tctctccttt
     8041 taataaagta attttttatt gccaagtata atatagtaca tacttttacc ctattaaata
     8101 tatcatatta tcatattttt atatatagta tgtaacatta tttaggtgta ttttatatat
     8161 tttttcttaa aaaaagtcct gagtccgtag tattaaacta caaactcgga ctttgtcaat
     8221 ctacttttct attttctcaa aactgactat tttgctaatt gtgcaaagta tcctaaagtt
     8281 cttattaatt gagaagtata agacatttca ttatcatacc aagaaacaac tttaactaat
     8341 tgttttccat ctacttccat aacttttgtt tgagtagcgt caaataatga accgtagctt
     8401 attccgatta tgtcagaaga tactaacatt tcttcagtat atccgaaaga ttcgtttgaa
     8461 gcttctttca tagctgcatt tatttcttca actgtaacat tttttcctaa tgtacaaact
     8521 aattcagtta ttgaaccagt tacaactggt actctttgtg ctgccccatc taattttcct
     8581 tttaatgaag gtattactaa gcctattgct tttgcagctc ctgtagtgtt tggaactatg
     8641 tttccagcag cagctctagc tcttcttaaa tcaccttttg gatgaggacc atctaaagta
     8701 ttttggtcat tagtgtatgc atgtatagta gtcattaagc ctttttctat accgtattta
     8761 tcatttaata ctttagccat tggagctaaa cagttagtag tacaagaagc tcctgatata
     8821 actgtttcag aaccatctaa tatgtcactg tttgtgttga atactattgt ttttaaatct
     8881 ccagtagctg gtgcagatat aacaactttc ttagcccctg cttgtatatg agcttcagct
     8941 ttatctttag atgtaaagaa tcctgtacat tctaatacta tatctactcc taattcagcc
     9001 catggtaggt cagcaggatt tctttctgct gttactttta tttcttttcc gtttactaca
     9061 aaagcacctt ctttaacttc tatttctccg ttaaatcttc cttgagctgt atcatattta
     9121 aataaatgag ctaacatttt agcgtctgtt aagtcgttta ttgcaacaac ttcgaactta
     9181 tcttgttgct ccatcatttt tcttaatgct aatcttccta ttcttccaaa tccatttata
     9241 gctactttaa ccattttcgc tacctcctat aaagtaaatg tatgttttct agctctgtgc
     9301 taggtcttga cttttataat aatgacaata tcttataagc actttcttca tctgttacaa
     9361 gaaccatgtt tttatgcata tttgatatag ctaataaggc ttctactttt tcagtccctg
     9421 caaagattgc aatagtttct tttacttgtt taactgtttc taaatcaatt ccaacagtgt
     9481 tcagtttgta aactatttct ccatctttgt tgaaataata tccaaatgct tctccaactg
     9541 catttttaga taatatctca tcaaccttgt cttctggaag ttttcttctc tttgccatga
     9601 catctgctct acctatacta aaaactaaaa tgtctgttct tttaatatac tccaaagttg
     9661 tcttaatctc tggcacttgg ctaagagttt tcattgcact ttcatccaac tcatctggta
     9721 tatgtaaaag tttgcaatta gaatgtaatt tcttacttat tgaagcaact atattgttag
     9781 attgcatctc tacatcagtt cccatacttc ctctagctgg aactattgta gagtttggat
     9841 atctcttatc agttttaata acgtttgaaa actccaacat agtgcttcct cctgttattg
     9901 aaacgatatc tccatctttt aaaatgccta agaaatattc gcatccatat ctagttacat
     9961 cttttagtaa acttccattt tcatcacagc ttccaggaac taatattacc ctttttattc
    10021 caagcttttc tctgactcta tcttgtaact tagacaatcc catgatgtca ctcatgatgt
    10081 ccttaagttt atctaacaaa tcagaacctt ctttagtgat agtcatccca gatacagcta
    10141 cgtctataag tccttgttct tttaaaaact cagtttctga cctgattatt ctttcactaa
    10201 tctctaatac atttgataat gttctcctac ctattggttc acttaaagat atttgtctta
    10261 aaatagagta tcttctttcc ataagttcaa ttgcctgtgg aatcaatttc ttttgaattt
    10321 ctaataagtt cttcataaca tactccttat tgctttcctt tcgggacttt ttttgtccct
    10381 agtgtttatt taagtcccac aagatatttt tattttatag gatttgcgta tagatttcaa
    10441 tagtttttca aaaacttttt tattttttta ttttataaaa tatttctcca ccattttcaa
    10501 atcacagtat tttttctttt tatataaggc tttttatata tattttttta ta
//
LOCUS       DAEHWM010000114        10346 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.117, whole genome shotgun sequence.
ACCESSION   DAEHWM010000114 DAEHWM010000000
VERSION     DAEHWM010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10346)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10346)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10346
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.117"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            361..1284
                     /locus_tag="KNP36_003249"
     CDS             361..1284
                     /locus_tag="KNP36_003249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2520 domain-containing protein"
                     /protein_id="HBF0875098.1"
                     /translation="MGSGKVGTSLANYFLSKGYCVSGFYGRNQLSLLESTNLTKTKIY
                     SNLKDIIYENDILFITTSDDSIEIIDKKLSKFNLKHKYICHTSGSLKSSILFCSKKAG
                     ALIYSIHPIFAFSNKNTDIKKMKDICFSIEGDNEQDDLVIQNFIDDLGNQFFIRDKDT
                     SSTYHLANVLVSNLVLSLLDIGVSYFIKLGLSEEESLKAISPLVKKNIENILDNGFTK
                     ALTGPVSRGDITPIRKHLSVLDKKDEDIYKILSLNLLKIIALGNDNSLKGIKNITIEN
                     AIENLISKSEKYKEIYKLLGGKNDEKYHTDF"
     gene            1259..2086
                     /gene="panB"
                     /locus_tag="KNP36_003250"
     CDS             1259..2086
                     /gene="panB"
                     /locus_tag="KNP36_003250"
                     /EC_number="2.1.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-methyl-2-oxobutanoate
                     hydroxymethyltransferase"
                     /protein_id="HBF0875099.1"
                     /translation="MKNTIQTFKNAKYEGKKLSMLTAYDYSIAKIMDECDINGILIGD
                     SLGMVIKGEENTLSVTIDEIIYHTKAVKNGVKNALIVSDMPFLSYHVSIEDAVKNAGR
                     LIKEGGAHAVKLEGGSNVIKQIESIVNAQIPVMGHLGLTPQSVNSFGGFKVQGNTSET
                     ARQLIEDAKLIEKAGAFSIVLEGVPTKIAEMVTNSISIPTIGIGAGINCDGQILVYQD
                     MLGMFGDFVPKFVKQYANIGDIIKDSIKNYILEVNTGAFPQEKHSFSINESELEKLY"
     gene            2105..2953
                     /locus_tag="KNP36_003251"
     CDS             2105..2953
                     /locus_tag="KNP36_003251"
                     /EC_number="6.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantoate--beta-alanine ligase"
                     /protein_id="HBF0875100.1"
                     /translation="MLVKEIKLLRNIIKDWRKHGYSIGLVTTMGFLHEGHQSLIKKAV
                     KENDKVVVSIFVNPTQFGPNEDFNSYPRDIDKDFKYCMDSGATVVFNPSPEEMYLKGN
                     CTTINVSGLTDFLCGAKRPVHFGGVCLVVSKFLNIVTPDKAYFGEKDAQQLAVIKRMV
                     KDLNIDTEIIGCPIIRENDGLAKSSRNTYLSEEERKSALILNKSLSLAKEELVKGNLN
                     PENIKELITAKINSEHLAKIDYVEIVDSETLQPVKQIEHSILVAIAVFIGKTRLIDNF
                     TFELNI"
     gene            3364..3546
                     /locus_tag="KNP36_003252"
     CDS             3364..3546
                     /locus_tag="KNP36_003252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875101.1"
                     /translation="MFKDKIDECVHIMTAYIASLKEYYSFIETQIGDFIKKYGEDVVE
                     LCLHRVMILLCECGLA"
     gene            4373..5287
                     /locus_tag="KNP36_003253"
     CDS             4373..5287
                     /locus_tag="KNP36_003253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2935 domain-containing protein"
                     /protein_id="HBF0875102.1"
                     /translation="MIDNQKYVILSLELHLFFSRIMKEHALFLEAGFTNKNYNLAMEA
                     DHYKKQFEDLLSYTVSASNGIIRPDILYSEELVTTLTSVAEQKTEEFTGIEINKNITT
                     RELNLQSGVNPQVGQDLVNYVAQLNSDAIRLLDGLINFKERVLDGVLSCTIFTSNYPL
                     LLEHIIHEANLYRSYVVDLENKIDIESKNAKEIELFWDHIMMEHALFMRGLLDPSEGE
                     LINTSNDFAIKFNELIEKTNEMTDSNIKNITEETLNETVEFKDFKEAGASGIEQCKIK
                     SIILPLLADHVLREANHYIRILESYKNM"
     gene            5677..6324
                     /locus_tag="KNP36_003254"
     CDS             5677..6324
                     /locus_tag="KNP36_003254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate utilization protein"
                     /protein_id="HBF0875103.1"
                     /translation="MIRQTPLEKRYDKLGPHIVTALKKRYFDAYYCKTRNEALQQILD
                     LIPQNHVVSWGGSETLKEMGVQTAVREKGFKVIDRDLAKTPEERTEIMRQALLCDTFL
                     MSSNAISEDGQLFNIDGNGNRVAAMIFGPKNVIVVAGMNKIVKNIDDAIQRTRTIASP
                     AVVQRFQDVNTPCYINGSCIDCTSPESICAYMVTTRISRPAKKIKVILVGENLGL"
     gene            complement(6491..7060)
                     /locus_tag="KNP36_003255"
     CDS             complement(6491..7060)
                     /locus_tag="KNP36_003255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875104.1"
                     /translation="MKKFILCIIMFAISVLVLAGCTNDNKIKNEVDSMFNSIKTQDAD
                     TVDKYFPKSGLGNLIYEDKEGFKMYSKNMTWEISDIKNNKDKVTVDLKINNTDMVSIL
                     KKNPPKLGEMMPNPTMKDIDSAKKKEFNITLELVKSGDNYVCKVNQESAMKLLNVITG
                     GGIDYLADYNKDYYKQLDEEQKNYENKNS"
     gene            complement(7065..7964)
                     /locus_tag="KNP36_003256"
     CDS             complement(7065..7964)
                     /locus_tag="KNP36_003256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0875105.1"
                     /translation="MKLLSKVNNNIRLITQVAFTALTNGYVNGFLEGTIYGGESKKLC
                     VPGLNCYSCPGALGACPIGSLQAVLSSREYKFSFYVVGFLMAFGAFFGRFVCGWLCPF
                     GLVQDLLHKVPFPVKIKKVYGDKYLKYLKYIVLIIFVIILPVAIVNVAGGGNPWFCKW
                     ICPSGTLLGGIPLILGNENLRESIGFLFSWKLSILLLILLMSIITYRPFCKYICPLGA
                     IYGFFNPISIYRFKIDKDKCTNCTACQTKCKLDIPIYKDVNSPDCIRCGECIKVCPQN
                     AITTTFSKDKKENNICAKKYRGI"
     gene            complement(7975..8124)
                     /locus_tag="KNP36_003257"
     CDS             complement(7975..8124)
                     /locus_tag="KNP36_003257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875106.1"
                     /translation="MSNFIKDNKKGISIIAISIIFIALGTYRGETNTVLTKAIMICLE
                     CIGIG"
     gene            complement(8117..8701)
                     /locus_tag="KNP36_003258"
     CDS             complement(8117..8701)
                     /locus_tag="KNP36_003258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlpA family protein disulfide reductase"
                     /protein_id="HBF0875107.1"
                     /translation="MKRFFIVVLGCICVLGMISGCSKKESKPVEKNKNNSEWFSNLDT
                     EDVDGNKVTKEIFSNKELTLINVWTTWCGPCVGEMPELEALSKEYESNNSNVAIKGLV
                     VEVDKTDMRTGLSNEEKNLVKDIMKKSDATYQQLTVSEELKKTDFKRVMEFPTTYFVD
                     KKGNFVGEKVVGANSKEDWKKIIDERLKMVKANE"
     gene            9090..>10346
                     /gene="cdeA"
                     /locus_tag="KNP36_003259"
     CDS             9090..>10346
                     /gene="cdeA"
                     /locus_tag="KNP36_003259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MATE transporter CdeA"
                     /protein_id="HBF0875108.1"
                     /translation="MENLFTRKFTTFEFLKFVSPAIISMIFISLYTIIDGIFVSTLVG
                     SDALASINIVLPIINLVCGFGIMMATGGGAIVSIRMGENRQDEANSTFSFIVLFSLIV
                     GILFTVISYFFIKEISILLGATDKLLPYCITYGKVMILCTPFYILKFIFEYFARTDGN
                     SKFSLFLSVIGGVTNIILDYVFIKYFGMGLLGAAVATAIGIILTCVLGIIYFLSNKST
                     LKLRKPKTDFRLIRDTMINGSSEMVTELSTGITTFLFNVVALKLAGENGLAALTIVLY
                     AHFLMTSVYLGFAAGVSPLISYNFGAENSDKLKETFKHSLKFIFVSSLLVFIFALVFA
                     PFIVRVFVSPDNTVFKLALQGLKIFAFAFLFVGINIFASGFFTAFHNGKISAIISFSR
                     AFVFIIIGIIILPPMLNMTGLWLTVPF"
BASE COUNT         3842 a         1400 c         1355 g         3749 t
ORIGIN      
        1 taaattttta taaaaaatca gtattattga tactattgaa gttaaaaagc attaatttct
       61 aaaaacatca taatttttct aatagactta atcactttta atatatatag taaaacaaaa
      121 aacttatatt ttataaatat cataattttt ttactgatat tttattatat aaattttata
      181 gaattaattg tcaatttttt atgaaaatgg taagatattt atggatggta tcttgttata
      241 agaactatac tttaaatgtt tttaattatt ttgtcttatg taactcatat cctcaggaat
      301 gagattagaa attaagatgt tgtatcacaa agtggaggtg atactattaa aataggcttt
      361 attggttctg gaaaagttgg aacatctttg gcaaattatt ttttatcaaa aggttattgt
      421 gtttcaggct tttatggaag gaatcaatta tctttattag aatcaacaaa tttaacaaaa
      481 acaaagattt acagcaattt gaaagatata atttatgaaa acgatatatt atttattaca
      541 acatcagatg attctattga aattatagac aaaaaacttt ccaaatttaa tttaaaacat
      601 aaatacattt gccacacaag tggctcttta aaatctagta tattgttctg ttcaaaaaaa
      661 gcaggtgcat taatttattc tatccatcct atatttgcat tttccaataa aaatactgac
      721 ataaaaaaaa tgaaagacat ttgtttttcc atagaaggtg ataatgaaca agatgattta
      781 gttattcaaa atttcataga tgatttggga aaccaatttt ttataagaga taaggatact
      841 tcatccactt atcatttagc taatgtttta gtttcaaatt tagtattatc tttactagat
      901 ataggagtaa gttactttat taaattaggt ttatctgaag aggaatcttt aaaagctatc
      961 agtcctttag taaaaaaaaa catagaaaat atacttgata atggctttac taaagctctt
     1021 actggtcctg tttctcgtgg agatataaca ccaataagga aacatctatc tgtattggat
     1081 aaaaaagatg aggatattta caaaatacta tccttaaacc tactaaaaat aattgcctta
     1141 ggaaatgaca attcattaaa aggtataaaa aatattacta tagaaaatgc aatcgaaaat
     1201 ttaataagta aatctgaaaa atacaaagaa atttacaaac ttttaggagg aaaaaacgat
     1261 gaaaaatacc atacagactt ttaagaatgc taaatatgaa ggaaaaaaac tatctatgct
     1321 tactgcttat gactactcaa ttgcaaaaat aatggatgag tgtgatataa atggtatttt
     1381 aataggagat tcattaggaa tggtcataaa aggtgaagaa aacactctat ctgttaccat
     1441 agacgaaatt atatatcata caaaagctgt aaaaaatggc gtaaaaaatg ccttaatcgt
     1501 aagtgatatg ccttttctat cttaccatgt ttctatagaa gatgcagtta aaaacgctgg
     1561 tagacttata aaagaaggag gagctcatgc tgtaaagtta gaaggtggct caaacgttat
     1621 aaagcaaata gaaagcattg taaatgctca aatacctgta atggggcatt taggattaac
     1681 tcctcaatca gtaaattcat ttggtgggtt taaggttcaa ggaaatacca gtgaaacagc
     1741 aagacaactt attgaagatg ctaaattaat agaaaaagca ggtgcattct ctattgtcct
     1801 tgaaggagtg cctacgaaaa tagctgagat ggtaactaat tctatttcaa ttcctacaat
     1861 aggtataggg gcaggaatta actgtgatgg acaaatttta gtttatcaag atatgttggg
     1921 aatgtttgga gattttgttc ctaagtttgt aaagcagtat gcaaatatag gagatataat
     1981 aaaagattca attaaaaatt acatcctaga agttaataca ggtgcatttc cacaagaaaa
     2041 acacagcttt tcaataaatg aatctgagtt agaaaaatta tactaatatt aaggatggta
     2101 caaaatgctt gtaaaagaaa ttaaattact aagaaatata atcaaagatt ggagaaaaca
     2161 tggctattct ataggccttg ttacaacaat gggattttta catgaaggac accaaagtct
     2221 tataaaaaaa gctgtaaaag aaaatgataa agtagtagtg agtatatttg taaatccaac
     2281 tcaatttgga ccaaatgaag attttaatag ctatccaaga gatatagata aagattttaa
     2341 atattgtatg gatagtggag caacagtagt ctttaaccca tcaccagaag aaatgtattt
     2401 aaaaggtaat tgtactacca ttaacgtttc tggacttaca gattttcttt gtggagctaa
     2461 aagacctgtt cattttggag gtgtctgcct agttgtttca aagtttctaa atatagtaac
     2521 acctgataaa gcttattttg gagagaagga tgcccaacaa ttagctgtaa ttaaaagaat
     2581 ggtcaaggat ttaaacatag atacagaaat aataggctgt cctataattc gtgaaaatga
     2641 tggattagca aaaagttcga gaaatacata tctctctgag gaagaacgaa aatctgctct
     2701 aatattaaat aagagcttaa gtttagcaaa agaagaatta gtaaaaggca atctaaatcc
     2761 agagaatata aaagaattaa taacagctaa aataaattct gaacacttag caaaaataga
     2821 ctatgttgaa attgtagata gtgagacatt acaacctgtt aagcaaatag aacattctat
     2881 acttgtggca attgctgtgt ttataggaaa aaccagacta attgataatt ttacatttga
     2941 gttaaatata tagtctataa ttttatataa tatatctaaa aaataataga atacctaaaa
     3001 agtaataaat tacctaaaaa ataataaatt gcttagaaaa taatagatta caataactaa
     3061 aattttaaaa ttaaattcct taaaagtatg attaattata attatataag tatattctta
     3121 ttacacttat attaatttat attaaatatc tactaactca aatattcata attaaacttt
     3181 aaactggata aattttcttt taagaatgaa agtttatcca gttttgcgat tataataacc
     3241 agttttacat atccacttgt aaaatatatc taagcaatat atcatactat atagatttat
     3301 gagtgaaata atatctgcta tttactgaat atttttattt ttcgtttttt agggggatta
     3361 gttgtgttta aagataagat tgatgaatgt gttcatataa tgactgcata tattgctagt
     3421 ttaaaagaat actattcatt catagaaact caaattggtg attttattaa aaaatatgga
     3481 gaagatgttg tagagttatg tctccataga gtgatgattc tactatgcga atgtggtttg
     3541 gcataaaatt aaatttatta aaatgggtaa gaagaatcct atataatatt cttcttaccc
     3601 attttaatat atcaatttca tagcttatcg tttaaaatat tttacatcca ttactagaca
     3661 actttacatt ctctttttaa ttctagtata tttaaatcat tttagttgct ccttatttat
     3721 tcttattact tgttttattt ataaaataat tctttttaat aatgtttttt gttgatattc
     3781 ctatcacaca tccaattatt tatcattgtc ttgaaattgt ttgcatactt aatttaatcc
     3841 aattgaaaca ccccagcata gaatcccctg taaaatagaa gttggattaa atcctaacat
     3901 ctatacagaa aatactactc caagcacaag caatataatg gaatatattt atcacttaat
     3961 tttttatact ttttaaatcc catacctaaa acattaagtg cagctattag aattaataat
     4021 tgttgtggta taaaattatg cttgcttcat atttattcat tttttgctat aaaagttctt
     4081 gttttacaaa aaacatttgt tttgtatcaa aataatactt ataaattaca taattctcat
     4141 aaaaatttct agtattactt gtactcttaa taaataatag ccaacaagta ccttaaatca
     4201 ttatatctat atctaataag aaacacagta agataatctt ttcgcccata acttaataaa
     4261 aactgttgat attagtagca attgaattta gttaatttat ttataatata cataaattta
     4321 aatattacga ataaagtatt ataaatagga tactttctaa ggggaggaaa ttatgataga
     4381 taatcaaaaa tatgttattt tatcactaga attacattta tttttttcaa gaattatgaa
     4441 agagcatgct ctttttttag aagcaggatt cacaaataaa aattataatc ttgctatgga
     4501 agctgaccac tataaaaagc aatttgaaga tttattatca tacactgtta gtgctagtaa
     4561 tggtataatt agacctgata tattatattc agaagagctt gtaactactc tcacatcagt
     4621 tgcagaacaa aaaacagaag agtttacagg gatagaaata aacaaaaaca tcactacaag
     4681 agaattaaat ctacaaagtg gtgtaaaccc acaagttggt caagacttag tgaactatgt
     4741 agctcaactt aactctgatg caataagatt acttgatggg cttattaatt ttaaagaaag
     4801 agtcttagat ggtgtactat catgtactat atttacatca aactaccctc tacttcttga
     4861 acatataata catgaagcaa atttatatcg ttcttatgta gttgaccttg aaaataaaat
     4921 agatattgag tcaaaaaacg ctaaagaaat agaattattc tgggaccata ttatgatgga
     4981 acatgctctg tttatgagag gattactaga cccctcagaa ggtgaactaa taaatacttc
     5041 aaatgatttt gctataaaat ttaatgaatt aattgaaaaa acaaacgaaa tgactgattc
     5101 taatatcaag aacattacag aagaaactct aaatgaaact gttgagttta aagattttaa
     5161 agaagcagga gcatcaggaa tagaacagtg taagataaaa tctataatat taccactttt
     5221 agcagaccat gttttaagag aggcaaatca ttatattaga atattggaga gttataaaaa
     5281 catgtaatta aaaattactt ttaaaataat ctttgcatat ttagataaaa taaaggtaca
     5341 gttaactgta cctttatttt ttataaactt ataaaattta aacaagttat tcataaaata
     5401 aaataataat catctataac ccacaacttt attttatatt aaataaaaag tattagtggt
     5461 tatgttttat aagtatttct ttattcagtt atttattaaa aactaatagt aaatcttata
     5521 ctaatcgcat atttatgtta taactatatt gtaactattt tcgtaatctt aggaaaagat
     5581 tacttataaa attaacctta tacaataata tatcgtataa tcttaattag cataatagtt
     5641 acaatattaa aatttaaata tgggagtgat tttagtatga taagacaaac accattagag
     5701 aaacgatatg acaagctagg tcctcatatt gtaacagcac tcaaaaaacg ttattttgat
     5761 gcttattact gtaaaactag aaatgaagct ttgcaacaaa ttttagattt aattcctcaa
     5821 aatcatgtag tatcatgggg aggatctgaa acacttaaag aaatgggcgt acaaactgct
     5881 gttagagaga aaggatttaa agttattgat agagatttag caaaaactcc agaagaaaga
     5941 actgaaatta tgcgtcaagc acttctatgc gatacttttt tgatgagtag caatgcaatt
     6001 agtgaagatg gacaactctt taatattgat ggaaatggca atcgtgtagc tgcaatgata
     6061 tttggtccaa aaaatgttat agttgtagct ggtatgaata aaattgtaaa aaacattgat
     6121 gatgcaatac aaagaactag aacaattgca tctccagcag ttgttcagcg ttttcaagat
     6181 gtcaatacac catgctatat taatggaagt tgtatagatt gcacaagtcc tgaaagcatt
     6241 tgtgcataca tggttactac aagaatcagt cgtccagcaa aaaaaataaa ggtaatattg
     6301 gtaggagaaa atcttggtct ataaaatata catacatgta aatagctcta taaataataa
     6361 aatcatatga aataacttat ttctaaaagt ggtagaataa aagcttctac aagactttca
     6421 ttctgccact tttatattct tttaatttgt gtttctatat tattaattgc tccaattttc
     6481 atatatatta ctaactattt ttattttcat aatttttttg ttcttcatca agctgtttat
     6541 aataatcttt attatagtca gctagataat ctataccacc tcctgtaatc acatttaata
     6601 atttcattgc agattcttga ttaactttac aaacataatt atcaccagat ttaacaagct
     6661 ctaatgtaat attaaattct tttttctttg cagaatcaat atctttcata gttggatttg
     6721 gcatcatttc tcctagttta ggaggattct tttttaaaat agaaaccata tcagtattgt
     6781 taatttttaa atctacagtc actttatcct tattattttt tatatctgaa atttcccaag
     6841 tcatattttt agaatacatt ttaaatcctt ctttatcttc gtatataaga ttacctaacc
     6901 ctgattttgg gaaatactta tcaacagtat ctgcatcttg tgtttttatt gaattaaaca
     6961 tactatccac ttcatttttt atcttattat cattagtaca accagctaac accagtactg
     7021 atattgcaaa cattataata catagaataa atttcttcat taaattatat ccccctatac
     7081 ttttttgcac aaatattatt ctctttttta tcttttgaaa aagttgtagt aattgcattt
     7141 tgtggacaaa cttttataca ttcaccacac ctaatacagt ctggactatt tacatcttta
     7201 tatattggta tatcaagctt acattttgtt tgacatgctg tacaatttgt acatttatct
     7261 ttatcaattt taaatctata tattgaaata ggattaaaaa aaccatagat tgctcctaaa
     7321 gggcatatat acttgcaaaa tggcctataa gtaatgattg acatcaataa tatcaataac
     7381 aaaatactta acttccagct aaataaaaat cctattgatt ctcttaaatt ctcatttcct
     7441 aaaataagtg gtattcctcc caaaagtgtt cctgaagggc aaatccattt acaaaaccaa
     7501 ggatttccac cccctgctac atttacaata gcaactggca aaataattac aaatattatt
     7561 aagactatat actttagata ttttagatat ttatcaccat aaactttttt tatctttact
     7621 ggaaagggta ctttatgtag taaatcttgt acaagtccaa agggacaaag ccaaccacaa
     7681 acaaatctgc caaaaaaagc accaaatgcc attaaaaaac caacaacata aaatgagaat
     7741 ttatactctc tgcttgataa aactgcttgt aatgaaccta ttggacatgc tccaagtgca
     7801 cctggacatg aataacaatt caatccaggt acacataatt ttttactttc tcctccatat
     7861 atagttcctt ctaaaaatcc atttacatat ccatttgtta atgctgtaaa tgcaacttga
     7921 gtaataagtc ttatattatt atttacttta gataataact tcattcctct tctcctaacc
     7981 aataccaata cactcaagac aaatcataat tgctttagtt aatactgtat ttgtttctcc
     8041 acgatatgta cctaatgcaa taaatataat actaattgca ataatagaaa tgcctttttt
     8101 attatcttta ataaagttac tcattggctt ttaccatttt tagtctttca tctataattt
     8161 ttttccaatc ttccttacta tttgcaccta caaccttctc acccacaaag tttcctttct
     8221 tgtctacaaa ataagttgtt ggaaactcca taactctttt aaaatcagtt tttttaagtt
     8281 cttcagatac agtcaattgt tggtaagttg catctgactt tttcataatg tctttaacta
     8341 aatttttctc ttcatttgaa agaccagttc tcatatcagt tttatcaact tctacaacta
     8401 atccctttat agctacattg gaattattac tctcatattc ttttgataat gcttcaagct
     8461 ctggcatttc acccacacat ggtccacacc aagtagtcca gacattaata agagtaagtt
     8521 ctttatttga aaatatctct tttgttacct tatttccatc aacatcctcc gtatctaaat
     8581 tactaaacca ttcactatta ttcttgtttt tttctactgg cttagattct tttttgctac
     8641 atccagaaat catacctaaa acacaaatac atcctaaaac tactatgaaa aaccttttca
     8701 tatctcacac tcctagaatt tatatagtat ataaaatcgc tgcttgaaat aaaaataact
     8761 tatcttctat attaaagtaa ttatatttaa taaataagag ctaatttaaa aaaagatata
     8821 cagttaaaat ctatttcttt tcagacaaaa tcttatatat atataatagc ttgtaaatct
     8881 taagattata tacatatatt tctaaagatt ttcttaagaa acagttagat tttactaata
     8941 taagtttatt aattagcatt atactaattt atcttaatat gattttttgt tgattttaag
     9001 ctgtttatcg tataaataaa atttttcttg actatatagt tactatatag cttattatat
     9061 atagagagta ataaaaggag gtaaaattta tggaaaattt atttacaaga aaattcacta
     9121 cttttgaatt tctaaaattt gtttctcctg caattatatc catgatattt atatctttgt
     9181 acacaataat agatggcatc tttgtatcga cattagttgg ttctgatgct cttgctagta
     9241 taaatattgt actacctata attaaccttg tttgtggatt tggaataatg atggcaactg
     9301 gtggaggtgc tatcgtttct atacgtatgg gtgaaaatag acaggatgaa gccaactcta
     9361 cattttcttt tatagttttg ttttcattga ttgttgggat tttattcaca gtaatctcat
     9421 atttctttat caaagaaata tctattttgc ttggtgcaac agataagtta ttaccatatt
     9481 gtataactta tggtaaagtt atgattttat gtacaccatt ttatatttta aaatttatat
     9541 ttgagtactt tgcaagaact gatggaaatt ctaaatttag tttatttcta tcagtcattg
     9601 gtggtgtaac aaatataata ttggattatg tatttattaa atattttgga atgggtcttt
     9661 taggagctgc agttgcaact gctataggta ttattttaac ttgtgtttta ggtattattt
     9721 acttcttatc taataaatct acactaaaat taagaaaacc aaaaaccgat tttagactta
     9781 taagagatac tatgataaat ggttcttctg aaatggttac agaattatct acaggaatta
     9841 caacattctt atttaatgta gtagctttaa aattagcagg agaaaatgga cttgctgctc
     9901 ttactatagt attgtatgct cattttttaa tgacatcagt ctatctagga ttcgctgctg
     9961 gagtgtctcc attaataagc tataattttg gtgctgaaaa cagtgataaa ttaaaagaaa
    10021 catttaaaca ttctctaaaa tttatatttg tttcttctct tttagtgttt atttttgctt
    10081 tagtatttgc accatttatt gttagggtct ttgtaagtcc agataacaca gtatttaaac
    10141 tagccttaca aggattaaaa atatttgcat ttgctttttt gtttgttggt ataaatatat
    10201 ttgcatcagg attttttaca gcatttcaca atggaaaaat ttcagctatt atatctttta
    10261 gtcgtgcctt tgtttttata atcataggaa tcataattct tcctcctatg ttaaacatga
    10321 ctggattatg gcttacagtt ccattt
//
LOCUS       DAEHWM010000115        10337 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.118, whole genome shotgun sequence.
ACCESSION   DAEHWM010000115 DAEHWM010000000
VERSION     DAEHWM010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10337)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10337)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10337
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.118"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            207..1631
                     /locus_tag="KNP36_003260"
     CDS             207..1631
                     /locus_tag="KNP36_003260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454640.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannitol transporter subunit IICB"
                     /protein_id="HBF0875109.1"
                     /translation="MSSSNQSTIKTSIQRVGKFLSGMVMPNIGAFIAWGLITALFIPT
                     GWMPNEKLSTIGDPMIKYLLPLLIAYTGGKAIAGQRGGVIGAAAAMGVIVGADIPMFI
                     GAMIMGPFAGWVIKKFDKFVDGKIPTGFEMLVNNFSIGIIGMLLAILGFYAIGPAIVA
                     GTALIESGVQFIVSKSLLPLVSVFIEPGKVLFLNNAINHGILGPIGIAEAKEAGKSIM
                     FLLESNPGPGLGVLLAYWMFSRGSVKQSAPGAVIIHFFGGIHEIYFPYILMNPVLILA
                     TMAGGAAGILTFSILGAGLVAAPSPGSIFALMALAPKGGLLPVLAGVAVATVVSFLVA
                     APFVKRASANQSEEDSTSLEEAKAKMSDMKSASKNSEKNIEEKQLEVNEIKKIVFACD
                     AGMGSSAMGASRFKNRIKNLDLNIEITNSSVDNLPDDTQIVVTHNTLVERVAKNNSSV
                     EIVSINNFLNDPNLDTLFKRLESK"
     gene            1666..3795
                     /locus_tag="KNP36_003261"
     CDS             1666..3795
                     /locus_tag="KNP36_003261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HBF0875110.1"
                     /translation="MKKKKITSRQKKIILMIVANSKKNIPITISEIAGTLELSSRTVL
                     RDMSGIEKWFDENDFNFVKKPGVGLILEENIENQNFIIELLEEEKIEKEYSKEERNLI
                     ILSKLLVSNEPVKSYYFAKILKVSEWVLNNDFALASKWLERFDIELVRKPGLGVYLKG
                     QEKNFREAYVNLIYDSFNEKEILDMVRNISENIQTDKAIEILSENRLLNLMDRCIIRK
                     VEATLTKKLSDLDVNLADSAYIGLVVHISLALQRIKNGENITMDKEFLKELSITEEFK
                     LAKEIVKGMETDFNMDIPVDEVGYITMHIRGAKQRSSSNHKALNLDDIEIMEITNKMI
                     DLAEDEFKISLKNDERLFKDLANHLGPSINRLNMGLEIRNPLLDEIKSKYSYAYDVVE
                     KISRIIKDKLNINSIPESEIGYIAMHFASAIEKNLMMNTNINIVVACPTGIGTSRFLS
                     TKIENKFPNLNILETISAINIDEEYLKEKDVDLIVSTVELNTSLNYICVGPFMSLDDE
                     QIIKEKIKSIAQNKLINLNAKNDTKSKNKVYEQITESMNIGKDILQFLEEIRFEKFES
                     KDLSELIEDSSKIFAKSSEDIISIKESLKERLKISIPYIEESKILLLHCMSERIDIMK
                     LSIIKLENRIVLDSNEEIDNVVFMLLPKNSPSYQRQIMSEISGSLIDNIIFTNKINKF
                     SIEEMALEVKDIVFNFYTNRLKAFIDK"
     gene            3825..4247
                     /locus_tag="KNP36_003262"
     CDS             3825..4247
                     /locus_tag="KNP36_003262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0875111.1"
                     /translation="MSKVLNENNIFLGLDSVSKEEAITLAGRKLVENGYVKEEYIPAM
                     LEREKVMTTYMGMGVAIPHGVNEAKKEILSSGIVILQFPNGIDFDGEKAYLLIGIAGV
                     GDEHLEILSNIAVVLDDDLTERLKNSNDKQAFMEAFAN"
     gene            4266..5417
                     /locus_tag="KNP36_003263"
     CDS             4266..5417
                     /locus_tag="KNP36_003263"
                     /EC_number="1.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HBF0875112.1"
                     /translation="MKKAIQFGAGNIGRGFIGGLLVKSGYHVVFADVNEEILNSINKD
                     KKYTIHIRDVECIDEVIDNISAVSSIKEEIIDEIVQAEIITTAVGPLVLTKIASTIAK
                     GIKARKEKGLTSNLNIIACENAIYASSSLKEEVLKYLNKEEVEYLEMYVGFPNCSVDR
                     IVPPGKNENPLDVTVENFYEWNVEKQGFKGEIPTIVGMNLADNLMAYIERKLFTLNTG
                     HAITAYIGYLKGYKTIEESIKDKFICDIVKSAMVESGEGLIKKYNFDSEVHYKYIDKI
                     LNRFKNPYLNDDVLRVGREPLRKLSDKDRLIKPLMTAKSYGLSVDNLILGIGAALHYN
                     NSEDTQSVELQELIKSIGVKKAVAKIANISNDEELLNNIEKSYIFMKNL"
     regulatory      5523..5624
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            5807..6379
                     /locus_tag="KNP36_003264"
     CDS             5807..6379
                     /locus_tag="KNP36_003264"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HBF0875113.1"
                     /translation="MKALQEKILREGSVSGNDILKVDSFLNHQIDVAFLNEIGREFKE
                     RFKGEKVDKIFTIEASGIAIASIVSQYFDNAPVVFAKKSESKNLDKDVYETNVYSFTK
                     AREYSVKVSKKYINKGENILIVDDFLANGRAALGLKDLIEQAEANLVGVGIVIEKGFQ
                     AGGALLKANDVRLESLAVVESIDNGTVKFR"
     gene            6443..7093
                     /gene="fsa"
                     /locus_tag="KNP36_003265"
     CDS             6443..7093
                     /gene="fsa"
                     /locus_tag="KNP36_003265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HBF0875114.1"
                     /translation="MRFFIDTANIEEIKEANDLGVICGVTTNPSLIAKEGRDFIEVVK
                     EISEIVDGPISAEVISLEHKGMIEEAEKLSKIHKNIVIKIPMTAEGLKAVKVLSSKGI
                     KTNVTLIFSAGQALLAARAGATYVSPFVGRLDDISQNGLDLIEEIVDIFSVNSIEAQI
                     IVASVRNPIHVLQAARMGADIATVPLKVINQMIKHPLTDKGIDSFMKDWEGASLKL"
     gene            7245..10169
                     /locus_tag="KNP36_003266"
     CDS             7245..10169
                     /locus_tag="KNP36_003266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0875115.1"
                     /translation="MDKILREIQREDKKNPYTDQELAEMLNVARSEVISVRKKNNILD
                     SRERRKKILIKDISKIVSENPQMSERKITEILIENGYNISRSAVSKLLKEENLNQSKI
                     GIKDKDPASSGKYVKVSKVVEEDGFEELIGIKGSLKEKVNLAKSAIMYPPNGLHTIIY
                     GETGVGKSELATCMYKYAIKNNIKEENSPFIVFNCADYAENPNLLIAQLFGVVKGAYT
                     GADANREGLVEQANNGILFLDEIHRLPAAGQEILFSLIDRGEFRRLGESSSNRKANVL
                     IISATTENPDSNLLQTFRRRIPMVINLPNMSERPKSERYEIIIKFFEREAKRVNKNFI
                     ITKEVMCALMNYKCTGNIGQLKSDIQVTCARAFSKSIFSSDKVIIDLDSLRDYIKSGY
                     YDCNCKNEKYSEFSVEDIYIDISELVSGKNRILSDNEISEIYNYAEKELKVLESKCFS
                     EEELKNAFIEKLDKKFNAIKNNKNLSDRRSRIDWGGQLKESTLEIMDKVIVFIKEQFK
                     HVNQGLYLALAIHIEHAIGRIKDGKTIINPSLDKIKASMPMEYELSRYIMGIVEDLTQ
                     VTFPEDELGYLAYYINKFCYNEESIKDKVKVVIVTHGKVGIEMSKVVNHILGIECTLG
                     IEIALTDSPSEGIEHVLEELQKIEARKGILVLIDMGSLVILGDEVEKRLGIRCKTVNR
                     VDTLLAMEAGKLATIEGKSLDGIIADLKKNKNYAMINTNKFSYRKNEYGKKNVIITLC
                     LSGVGTALNLKEHIEKQIKEYDTLIEVKPVAFLNNNLEEELNDIESEYNIIAICGTID
                     IDYKNVPFISYNEVLGKNGINKVLEHLNSKQPALNIENQLNNLIHEDLILYNFEGISK
                     EYIIDTLVSKLEEGGYVDSKYILSVYKREAMGSVVMASKVAVPHGLPENVMKPAIAIA
                     RLNKPIVWDNKFMVDLVVLLALKENNKKEIRSLFSKINDQHTLEVLLNTEDKNEIKEL
                     LS"
BASE COUNT         4236 a         1008 c         1943 g         3150 t
ORIGIN      
        1 taaaaatagt attatttaca aaatcatata ctccaaaata ctacataaat aaaattaaac
       61 aaaaactaaa atgacaaatg tcattatcta aagtgacata gaaacggttt cttaaagttg
      121 ttactataaa atataaactc tataataaaa gtataacaaa agggaatcat atcgatatag
      181 aatataattc aagaggaggt aaaattatga gtagttctaa tcaatcgaca ataaagacat
      241 ctatacagcg agtagggaaa tttttaagtg gtatggtaat gccaaatata ggagctttta
      301 tagcatgggg tcttataaca gcattattta taccaacagg atggatgcct aatgaaaaat
      361 tgagtactat aggtgaccca atgataaaat accttttacc actattgata gcttatactg
      421 gtggtaaagc aatagcagga caaagaggtg gcgtaatagg tgcagcagca gctatgggag
      481 taattgttgg tgcagatata ccaatgttta ttggagcaat gataatggga ccatttgcag
      541 gatgggtaat taagaagttt gataaatttg tagatggaaa gataccaaca ggatttgaaa
      601 tgttagtaaa taacttttca ataggtataa taggtatgct tcttgcaata ctaggatttt
      661 atgcaattgg accagcaata gtagcaggga cagctcttat agaatctgga gttcaattta
      721 tagttagcaa aagtttattg cctctagttt cagtatttat agaacctgga aaagtattat
      781 tcttaaacaa tgcaataaat catggtatat tagggcctat aggtatagct gaggcaaaag
      841 aagcaggtaa atctataatg ttcttactag aaagtaaccc tggaccaggt ttaggagttc
      901 tattagcata ttggatgttt agtagaggaa gtgtaaaaca atcagcacca ggagctgtaa
      961 taatacattt ctttggtggt atccatgaaa tttacttccc atatatttta atgaatccag
     1021 ttttaatatt ggctacaatg gcaggtggag cagcaggaat attgactttt tcaatattag
     1081 gagctgggct tgtagcagca ccatcaccag gaagtatatt tgcacttatg gcactagctc
     1141 caaagggagg attacttcca gtattagcag gagttgcagt ggcaacagtt gtatcattct
     1201 tagtggcagc accatttgtt aagagagctt cagcaaatca aagtgaagaa gacagtactt
     1261 ctttagaaga agctaaagca aaaatgagtg atatgaaatc tgcaagtaag aactctgaga
     1321 aaaatattga ggaaaaacag cttgaagtaa atgagattaa gaagattgta tttgcatgtg
     1381 atgcaggaat gggttcgagt gcaatgggag cttccagatt taaaaataga ataaaaaact
     1441 tagacttaaa tatagaaatt acaaattcat ctgttgataa tcttccagat gatacacaaa
     1501 tagtagtaac tcacaataca ttagttgaaa gagttgctaa gaataattca agtgttgaga
     1561 tagtttcaat aaacaatttt ttaaatgacc caaatttaga tacattgttt aaaagattag
     1621 aatctaaata aaaataaaaa gtaccactaa ttaggagtgg ataatttgaa aaaaaagaag
     1681 attacatcta ggcaaaaaaa gataatacta atgatagtag caaattcaaa gaaaaacatt
     1741 ccaataacta tttctgagat tgcagggact ttagagttaa gttcaagaac tgtacttaga
     1801 gatatgtctg gaattgaaaa atggtttgat gaaaatgatt ttaactttgt aaaaaaacca
     1861 ggagtgggat tgattttaga ggaaaatata gaaaatcaaa actttataat tgagttgtta
     1921 gaagaagaaa aaatagaaaa agaatacagc aaggaagaaa gaaatttaat tatattatca
     1981 aagctactag tttctaacga gccagtaaaa tcctattatt ttgcaaaaat attaaaggta
     2041 tctgaatggg tactgaataa tgattttgcc ttagcaagta aatggttgga aagatttgat
     2101 attgagcttg ttagaaaacc agggctcggt gtctacttaa aaggtcaaga aaaaaacttt
     2161 agagaggcat atgtaaatct tatatacgat tcattcaatg aaaaagaaat actagatatg
     2221 gtcagaaata taagtgaaaa tatacaaaca gataaagcaa tagaaatttt aagtgaaaat
     2281 agacttttaa atttaatgga caggtgcata ataagaaaag ttgaagctac attaacaaag
     2341 aagctttcag atttagatgt aaatttagct gatagtgcat atatagggct tgtagttcat
     2401 atttcattag ccttacagag gataaaaaat ggtgaaaata taactatgga taaagagttt
     2461 ctaaaagaat tatctataac agaagagttt aaattagcta aagaaatcgt aaaaggtatg
     2521 gaaacagatt ttaacatgga tataccagta gatgaggttg gatatataac tatgcatata
     2581 agaggtgcaa agcaaaggtc atcttcaaac cataaggctt taaacttaga tgatatagaa
     2641 ataatggaaa ttacaaataa gatgatagat ttggcggaag atgaatttaa aataagttta
     2701 aaaaatgacg agaggttatt taaagaccta gcaaatcact tagggccttc tataaatagg
     2761 ttgaatatgg gattagaaat aagaaatcct cttttagatg aaataaaaag caagtattca
     2821 tatgcctatg atgtagttga aaagatttct agaattataa aagataaact aaatataaat
     2881 tcaatacctg aatcagaaat aggatatatt gcaatgcact ttgcatcagc catagaaaaa
     2941 aatcttatga tgaatactaa tataaatatt gttgtggcat gtcccactgg aataggtact
     3001 tcaagattct tatcaactaa gattgaaaat aaatttccta atttaaatat acttgaaacc
     3061 atatcagcta taaacataga tgaagagtat ttaaaggaaa aagatgttga tttaatagtg
     3121 tctacagttg agttaaatac aagtttaaat tatatatgtg taggtccatt tatgagttta
     3181 gatgatgaac agataatcaa ggaaaaaata aaatctatag ctcaaaataa attaatcaat
     3241 ttaaatgcga aaaatgatac taagagtaag aataaagtat atgaacagat aacagaaagt
     3301 atgaatatag gaaaagatat tcttcaattt ttagaggaaa ttagatttga aaaatttgaa
     3361 agtaaagatt taagtgagct tattgaagac tcatcaaaaa tatttgcaaa atctagtgaa
     3421 gatataatct ctataaaaga atcgttaaaa gaaagattaa aaatttcaat tccatatata
     3481 gaagaatcaa aaattctatt gttacattgt atgagtgaaa gaatagatat tatgaagtta
     3541 tcaataataa aactagagaa tagaatcgtg ctagattcaa atgaagaaat cgacaatgta
     3601 gtttttatgt tacttcctaa aaattcacca agttatcaaa gacaaataat gagtgaaata
     3661 agtggttcat taatagacaa tataattttt actaataaga taaataaatt ctctatagaa
     3721 gagatggcat tagaggtaaa agatatagtt tttaattttt atacaaacag attaaaagca
     3781 tttatagata aataaaatta atattaaaaa ggaaggttga tactatgagt aaagtattga
     3841 atgagaataa tatattttta gggttagata gtgtttcaaa ggaagaagct ataactttag
     3901 caggaagaaa attagttgaa aatggatatg taaaagaaga atatatacca gcaatgttag
     3961 aaagagaaaa agtaatgact acatatatgg gaatgggagt tgctattcca catggtgtaa
     4021 atgaagcaaa aaaagaaata ttatcttctg gaatagttat attacaattc cctaatggta
     4081 tagattttga tggagaaaaa gcatatttat taataggaat agctggtgtt ggagatgaac
     4141 atttagaaat actatctaat atagcagtag ttttagatga tgacttaaca gaaagactaa
     4201 aaaattcaaa tgacaaacaa gcttttatgg aagcttttgc caactaatct taggagggat
     4261 ttaaaatgaa aaaggcaatt cagtttggag caggaaatat tggaagaggt tttattggag
     4321 gcttgttagt taagtcgggt tatcatgtag tatttgctga tgtaaatgag gagatattaa
     4381 actcaataaa caaagataaa aagtatacta tacacataag agatgtagaa tgtatagatg
     4441 aagtaattga taatataagt gcggtttcat ctataaaaga agaaataata gatgagattg
     4501 tacaggctga aataataact acagcagttg gacctttagt tttgactaaa atagcctcta
     4561 caattgcaaa aggtataaag gctagaaaag aaaagggatt aacaagtaat ctaaatataa
     4621 tagcatgtga aaatgcaata tacgcaagtt cttctttaaa agaagaggta cttaagtatt
     4681 taaataagga agaagtagaa tatttagaga tgtatgttgg ttttccaaac tgttcagttg
     4741 atagaatagt tcctcctggt aaaaacgaaa atcctcttga tgtaacagtt gaaaattttt
     4801 atgagtggaa tgttgaaaaa caaggattta aaggggaaat accaactata gttggtatga
     4861 atttagctga taatcttatg gcttatatag aacgtaaatt gtttacactg aatacaggtc
     4921 atgctataac agcttatata ggatatttaa aaggatataa gactatagaa gagagtataa
     4981 aagataaatt tatctgtgat atagtcaaaa gtgcaatggt agaaagtgga gaaggattga
     5041 ttaaaaaata caattttgac tcagaagtgc actataaata tattgataaa attttaaata
     5101 gatttaaaaa tccatatctt aatgatgatg tattaagagt cggaagggaa ccattaagaa
     5161 aactaagtga taaagataga ttgattaaac ctttaatgac agcaaaatca tatggattat
     5221 cagttgataa tttgattctt ggaataggtg cagcgcttca ttataataat agtgaagata
     5281 ctcaaagtgt agaattacaa gagttgataa agtctattgg agtaaaaaaa gccgttgcta
     5341 aaatagctaa tataagcaat gacgaagaac ttttaaacaa tatcgaaaaa agttatatat
     5401 ttatgaaaaa tttataaatt tacttgaaaa aaagtagttc tgataaagta actataatat
     5461 attattctac acagtttgaa ttatttgttg aataatagag aattataata tataattaaa
     5521 aggaataaat taatatattt acctgtatat gtttgataat atggttcaaa tgtttctact
     5581 aagctaccat taatagcttg actacaggag tgaagaagat atagtttata cttattttaa
     5641 attatatatt aagttaatta ctttgaattt taagctcctg tctatgatat agacaggagc
     5701 ttttttagta ttttaatata aaatacttac aagaatagat agcaaaatta gaacaaatat
     5761 aattttttta ttaatataat tttagaaagg gctaggtgga agttcaatga aggctttaca
     5821 agaaaagata ttgagagaag gcagtgtttc aggaaatgat atactaaaag ttgatagttt
     5881 tttaaaccat caaattgatg tagctttttt aaatgaaata ggaagagaat ttaaagagag
     5941 atttaaagga gaaaaggtgg ataagatatt tacaatagag gcttcaggaa tagctatagc
     6001 atcaattgtt tcacagtatt ttgataatgc acctgtagta tttgcaaaaa aatcagaatc
     6061 taaaaatttg gataaagatg tatatgaaac taatgtatat tcatttacta aggcaagaga
     6121 gtattcagtt aaagtttcta aaaagtacat aaacaaaggc gaaaatatat tgatagtgga
     6181 tgattttttg gcaaatggaa gagctgctct tggacttaaa gatttaattg agcaagcaga
     6241 agctaactta gttggagtag gaattgtcat tgaaaaagga tttcaagctg gaggagcact
     6301 tttaaaggct aatgatgtaa gattagagtc tttggcagta gttgaatcta tagataatgg
     6361 aactgtaaaa tttaggtaat ttatgatatt atatacttgt gtttagcaca tattttaact
     6421 atgtaattat ggaggatttt ttatgagatt ttttatagac acagccaata ttgaagaaat
     6481 aaaagaagca aatgatttag gtgtaatctg tggtgtaact actaatccgt ctctaatagc
     6541 taaagaaggt agagatttta tagaggtagt taaagaaata agtgaaatag tagatggacc
     6601 aataagtgca gaagtaataa gtttagaaca taaaggtatg atagaggaag cagaaaaatt
     6661 atctaagata cataaaaata tagttataaa gatacctatg acagcagaag gtctaaaagc
     6721 ggtgaaagta ctatcaagta aaggtataaa gactaatgta acgcttatat tctctgctgg
     6781 acaagctctt ttagctgcta gagctggagc tacatatgta agtccttttg ttggtagatt
     6841 ggatgatata tcacaaaatg gtcttgattt aattgaagaa atcgttgata tatttagtgt
     6901 aaatagtatt gaggctcaaa taatagttgc tagtgttaga aatccaatac atgttttaca
     6961 agctgctaga atgggagcag atatagcaac agttcctctt aaagttataa accaaatgat
     7021 taagcatcct ttgacagaca aaggaataga tagctttatg aaggattggg aaggtgcttc
     7081 tttaaaatta taattataaa ctacgcttta taagtatatt aaagaggtta ttatggaaat
     7141 tctaagtaat aaggctaggc tattttgcct agtcttattt tggtgtataa tatattgaaa
     7201 catattattg aaatagatta attttttaag tgaggaggcg aaaaatggat aaaatattaa
     7261 gagagataca aagagaagat aaaaaaaatc catatactga ccaagaactt gctgaaatgt
     7321 taaatgtagc taggtctgaa gtgatatcag ttaggaaaaa aaataatatt ttagattcga
     7381 gagaaagaag aaaaaaaata ttaataaaag atatatcaaa aattgtaagt gaaaatcctc
     7441 aaatgtctga aagaaaaata actgaaatat taatagaaaa tggatataat atatcgagaa
     7501 gtgcagtttc aaaattatta aaagaggaaa atttaaatca gtcaaagatt gggattaagg
     7561 ataaagaccc agcatcatca ggaaagtatg tgaaggtgag taaagttgta gaagaagatg
     7621 gatttgaaga attgataggt ataaagggaa gtttgaaaga aaaggtaaat ctagctaagt
     7681 cagcaataat gtatcctcct aatggccttc atactataat atatggagaa acaggagtag
     7741 gtaaaagtga attagctaca tgtatgtata aatatgctat aaaaaacaac attaaagaag
     7801 agaacagccc atttatagtg tttaactgtg cagactatgc agaaaatcct aatctattga
     7861 tagctcaact ctttggggta gtaaaaggtg catatacagg agcagatgca aatagagaag
     7921 gtcttgtaga acaagctaat aatggaatat tgtttttaga tgaaattcat agattgcctg
     7981 ctgctgggca agaaatctta ttttcattaa tagatagagg agaatttaga aggttaggag
     8041 aaagtagttc taatagaaag gcaaatgttc tcataataag tgctacaaca gaaaatccag
     8101 attctaattt acttcaaaca tttagaagac gtataccaat ggtaataaat ttacctaata
     8161 tgagtgaaag accaaaatct gaaagatatg aaataataat aaagtttttt gaaagagaag
     8221 caaagcgagt aaacaagaat tttataataa ctaaagaagt tatgtgtgca cttatgaatt
     8281 ataagtgtac tggaaatata ggtcagttaa agagtgatat acaagtaact tgtgctagag
     8341 cttttagtaa atcgatattt tctagcgata aagtaattat agatttagat agtttaaggg
     8401 attatataaa aagtggatat tatgattgta attgtaaaaa tgaaaagtat tctgagtttt
     8461 cagttgagga tatatatata gatattagtg aattggtgag tggaaaaaat agaattttat
     8521 ctgataatga gataagcgag atatataatt atgcagaaaa agagcttaag gttttggaaa
     8581 gtaagtgctt ttcagaagaa gagttaaaaa atgcatttat agaaaagtta gataagaagt
     8641 ttaatgctat taaaaacaat aaaaatttat ctgatagaag aagtcgaata gactggggag
     8701 gacaattaaa agagtctaca ctggagataa tggataaggt aattgtattt attaaggagc
     8761 agtttaagca tgtaaatcaa ggtctgtact tggctctagc aattcatatt gagcatgcta
     8821 taggtaggat aaaagatgga aaaactataa taaatccgag tttagataaa ataaaagcat
     8881 caatgccaat ggaatatgag ttgtcaagat atataatggg tatagtagaa gatttgacac
     8941 aagtaacatt tccagaagat gagcttggat atttggctta ttatataaat aaattttgtt
     9001 ataatgagga aagtataaaa gataaagtta aagtagtaat agttacgcat ggtaaagttg
     9061 gaattgaaat gtctaaagtt gtaaatcata ttttaggtat agaatgtaca ctaggtatag
     9121 aaatagcact tacagattca ccatcagagg ggatagagca tgtattagaa gaacttcaaa
     9181 agatagaagc tagaaaaggt attctagttc taattgatat gggttctttg gtaattcttg
     9241 gtgatgaggt tgaaaaaagg cttggaatta gatgtaaaac tgtaaataga gtagatacat
     9301 tattggcaat ggaagcagga aaacttgcaa caattgaagg aaaaagttta gatggtataa
     9361 tagctgattt aaagaaaaat aagaattatg ctatgataaa tacaaataaa tttagttaca
     9421 gaaaaaacga gtatggaaag aaaaatgtaa tcattacttt atgtttgagt ggtgtaggta
     9481 cagctttaaa tttaaaagag catatagaaa aacaaattaa ggaatatgac actttaattg
     9541 aagtaaagcc agttgctttt ttaaataata atttagaaga agagttaaat gatattgaat
     9601 ctgaatataa tattattgct atctgtggaa ctattgatat agattataaa aacgtgcctt
     9661 ttatttctta taatgaggta cttggtaaaa atggtattaa taaagtatta gagcatttaa
     9721 atagtaaaca accagcttta aatattgaaa accagttgaa taatttaata catgaagatt
     9781 tgattttata caattttgaa ggaatttcaa aggagtatat aattgatact cttgtttcaa
     9841 aacttgaaga aggtggatat gttgactcaa agtatatatt aagtgtatat aaaagagaag
     9901 caatgggaag tgttgtaatg gcctctaagg tagccgtgcc acatggactt ccagaaaacg
     9961 ttatgaagcc tgcaatagca atcgcgaggt tgaataaacc tatagtatgg gacaataaat
    10021 ttatggtgga tttggtggta ctactggcac ttaaagaaaa taataagaaa gaaatacgaa
    10081 gcttattttc aaagattaat gaccagcata ctttagaagt tttattaaat actgaagata
    10141 aaaatgaaat aaaagaactt ttaagctaat tattagtacc gagaagaaag acaaaaaaat
    10201 ttgctttagt ataaaattta aaactactca attgctaagt agttaattac tctatataag
    10261 gctagttcta tgaaatttat ttatatgatt ttatagaatt agcttttttc ttggtaaata
    10321 aaatatataa atttatt
//
LOCUS       DAEHWM010000116        10118 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.119, whole genome shotgun sequence.
ACCESSION   DAEHWM010000116 DAEHWM010000000
VERSION     DAEHWM010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10118)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10118)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10118
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.119"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            165..1046
                     /locus_tag="KNP36_003267"
     CDS             165..1046
                     /locus_tag="KNP36_003267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0875116.1"
                     /translation="MPAYLFDSNSIANIYRVFPISFSFIVTGLYFSYKNNKNNKINFE
                     AVLEDKKNLIFLLSLMFGMYLYLCLSLSIYYTVGNVLILKLYGIKSAIIVLVGNYIAE
                     RYSFRITQIKGYDIKNQIEYVESVKTEYEINKLNDIVYTDLLTGFYNRPFVNQKLSEW
                     TSNHYKFTLCFTDLNSLKPVNDKFGHQFGDKYISTTAQIIKKLINVENSLLFRYGGDE
                     FLFLLQNTSCVEAEKIMININYELSKLSNTDEYPYALSISYGLVEWDGISDIETLISK
                     ADSLMYENKLKNKSTLN"
     gene            1031..1404
                     /locus_tag="KNP36_003268"
                     /pseudo
     CDS             1031..1404
                     /locus_tag="KNP36_003268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418025.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
     gene            complement(1664..4231)
                     /locus_tag="KNP36_003269"
     CDS             complement(1664..4231)
                     /locus_tag="KNP36_003269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002602373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate, phosphate dikinase"
                     /protein_id="HBF0875117.1"
                     /translation="MIYYVLPLEHKQATIEIVGGKGMSLSKLLTAGIPVPDGFHVTTA
                     SYQIFVETNHIQSRINKLLDGIDSNNTSQLEDVSKKIGELFHNGEMPQEVSDAIKMAY
                     AGLGNISVAVRSSATAEDLPDASFAGQQETYLNIQGEDKVIDSVKRCWASLWTARAIA
                     YRVKNNIKHEIVALAVVVQKLAFSDSSGIMFTLNPINGRRSEMIINAAWGLGEAVVSS
                     LVTPDTIVVDKDSERIISYEVANKEIMTVRTSEGTEETMVPERLRKKYALTRNQVMQL
                     IQLGKKIEKYYQMPMDVEWALEKDKLYIVQARPITVLPPEWVLPEQDVVYTKGSLAEH
                     LPNPVTPLFATLGLEIVNRASELLWIDMFGKSAKKLLPKNGAYTVINGYVYLSAKSKP
                     LLIAIKSLSPRSLRRTLMNSVARWETARKGYEDAIKQWEEKPLHTMNAHQIMEGIQTI
                     FYAACIYFTRIQLTLPAASISETLFTKLFQGAVRRAGITDTSVFLLGFDTIVLQSEKE
                     LWGISEWVKQNNSINLYLQNSPAIKIAEDFMSSVVPVGVSQEVWIEWKNRINKYFKEF
                     GRTAYEFDFAHSTPQETLTPTFESVKTFVEGKGESPFLRQTTFEKRRKHAEEEILQHI
                     GGLRKKLFFKLLHWAQETSPMRENAIYLMGMGHPLIRCMFQEISERFIRGGAISHLDD
                     IYWLTKSELEVLIEQLDKNKSLSDMNGIIPVRKAELKKYMGYMSPSKLPEKNKKTISQ
                     AQQKQKDGKIVLTGIGTSTGVVTAPACVLNSPADFESFQPGSVLVAVTTTPAWTPLFS
                     SASAIVTDIGGPLSHSSIVAREYGIPAVMATHIATRTIKSGQMITVDGLAGTVTFDE"
     gene            complement(4234..4839)
                     /locus_tag="KNP36_003270"
     CDS             complement(4234..4839)
                     /locus_tag="KNP36_003270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002591427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0875118.1"
                     /translation="MPKGIVLTPEQQAERREKIVAVALSLMAENGFQKTSMREIAVLA
                     NMGKSSLYDFFKTKDEIVVYAVEKEIEKTIQQVHRIIDGEPSPQQCLRKIMLNHLRFP
                     EQYRTVLMWLNTESDYLEEEYRKRLKDARYAYQDIIKSVIDNGVTTGIFRKTDTALVT
                     RLLINSMLSISYTSRPLDSSEKMLDETMNIFLNGIMNDGGE"
     gene            complement(5213..6673)
                     /locus_tag="KNP36_003271"
     CDS             complement(5213..6673)
                     /locus_tag="KNP36_003271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HBF0875119.1"
                     /translation="MFNELKTKENVYKNLINGKWVESNSRKPIEIYSPIDNSLVGKVQ
                     SMTKHEVDEVIKNTKESIKVWAEMPVYKRGNIFHKAADLLLENIDEIANILVLEIAKD
                     IKSARAEVERTADFLRYTADVGKNMEGEAISGDNFPGGTRNKMSYVSRVPLGTVLAIS
                     PFNYPVNLSMSKIAPALIGGNAVVLKPATQGAISALHVVEIMRKAGIPDGVLNTITGR
                     GSEIGDYVVTHKGINFINFTGSTEVGQHISKISGMVPLLLELGGKDAAIVLEDADLDF
                     AAKNIVSGAYSYSGQRCTAVKRILVQESVADKLVGKIKPLVEKLTIGNPMDEVVITPL
                     IDNKATDFVQGLVDDALHKGAKLITGNVRKNNLFYPTLLDNVNVDMKIAWEEPFGPVL
                     PIIRVKDINQAIEIANQSEYGLQSSVFTSDIDKAFYIADKLEVGTVQINNKTERGPDH
                     FPFLGVKASGMGTQGVKYSIEAMTRPKAVVVNVREL"
     gene            7043..7621
                     /locus_tag="KNP36_003272"
     CDS             7043..7621
                     /locus_tag="KNP36_003272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0875120.1"
                     /translation="MAKSFTEIEKDNIRKRLISECEINWSKYGYKKTNIDELCSKSGI
                     AKGSFYTFFDSKEKLFFEVLNGIQNRLISSVDEILSNMPPKEGFAKSLKMLYRLYDKN
                     PFLYSPNNPDFISLINKLPQDMFLQLESNNIQSFYDLIERHNLKLKIEKEKVFGVCNA
                     LLSSLLVKENIEYNYIEVFDFMVDNLVEHILE"
     gene            7912..9162
                     /locus_tag="KNP36_003273"
     CDS             7912..9162
                     /locus_tag="KNP36_003273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0875121.1"
                     /translation="MVKSSNTFNKNFNLMILGQIISLFGASILKFALSLYILDITGKA
                     EIFATILAVSSIPIIVFSPIGGAIADIFNRRNLMVIFDFSSSLTVLILAVFLFNNNGS
                     ILLVGIIMTILSVISTMYQPTVQSSTPLLVDNEHLMNANGIVAGVASLTNIAGPVLGG
                     VLYGVIGINAIIVISCVSFFLSAIMEIFIQIPFIKQEQNSNIIKTIFTDIKDGIVHIC
                     KENRFILKILFLAIAINLFLSSMLIVGIPYIVKITMGASNFLYGLAEGAISFSSLVAA
                     VSIGIFSKHLKITNLHISFIICAVMFIPMAVSVYPFILNTGFPVPFLIFIVSSMLIFF
                     TTTLISIYVITVTQLKTPNELLGKVMSILFAGTAIAMPLGQVMYGKLFDLLSDRVYII
                     ILGVGFITLLIAFVSKITLRNENL"
     gene            9323..9892
                     /locus_tag="KNP36_003274"
     CDS             9323..9892
                     /locus_tag="KNP36_003274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase"
                     /protein_id="HBF0875122.1"
                     /translation="MSYMPTLEQAWEILRKYNKEEFHIRHAQIVSGVMRYYAKEYDPE
                     RVEFWEIVGLLHDLDFEMYPDEHCVKQRELMTELDLDKSIIDSTISHGYGLTGSDVKP
                     EQFMEKVLFAVDELTGLIGAAAIMRPSKSVSDLELKSVKKKFKDKSFAAGCSRDVIRS
                     GAEMLGWELDKLIQTTIEAMRSLIPEMAI"
BASE COUNT         3393 a         1736 c         1478 g         3511 t
ORIGIN      
        1 atctaattat aaattggaca atttttatgt tgattttatt catacaaatt aaagtaactt
       61 ataaaatctc cacaataaaa aacatttttt attcactaaa ctgctccatc attggtttag
      121 caataaatat attttttagg tctttaatgt caatagtgtt aaatatgcca gcatatttat
      181 ttgatagtaa ttctattgca aatatttaca gagtatttcc tatatcattt agctttatag
      241 ttacaggact atatttcagt tataaaaata ataaaaataa taagattaac tttgaggcag
      301 ttttagagga caaaaaaaac ttaattttct tattgagcct tatgtttgga atgtacttgt
      361 atctatgttt gagtttgtca atatactata ctgttggaaa tgtattgatt ttaaaattat
      421 atggaatcaa gtctgccata atagttttgg taggtaacta tattgcagaa agatatagct
      481 ttagaattac tcaaataaaa ggttatgata ttaaaaatca aatagaatat gtagaaagtg
      541 taaagacaga atatgagatt aataaattga atgatattgt atatacagat ttactgacag
      601 gtttctacaa tagacctttt gtgaatcaaa aactatcaga atggacatca aatcactaca
      661 aatttacctt atgttttact gatttaaata gcttaaaacc tgtaaatgat aaatttggac
      721 accaatttgg tgataaatac atatccacta ctgctcaaat aataaaaaaa cttataaatg
      781 tagaaaattc cttactattt agatatggtg gagatgaatt tttattcctt ttacagaata
      841 caagttgtgt agaagcagaa aagataatga ttaatataaa ttatgaatta tcaaaattaa
      901 gtaatactga cgagtatcct tatgctcttt ccataagcta tggattagtt gagtgggatg
      961 gaatatccga tattgaaact ttaatatcaa aggcagattc tttgatgtat gaaaataagc
     1021 ttaaaaataa atctacttta aactagctag ttaagatatt ctacaaaata tatgttataa
     1081 gagagtacta agaatatcaa aatatataga ttttgcaaat attgaataca gtttactaat
     1141 gaatgcactg gatgtaagtg ttagtaaaca cctattagat gaacacttta ctgttgtttg
     1201 ggctaatgac cgttattatg aaatgttcag ctatacctag ctaaaaagtt aaaaatgacc
     1261 actgtagccg agggaataga gaccagtttt caaaaagatt tcttgcaaga aataaactgt
     1321 gatatgttac aaggatacgt gttctctaga cctttaccaa taaaagactt tgaaaaactt
     1381 atgtttcaaa actcctccaa ttaacaatat aaaattgctt attataagtg atattattgt
     1441 atcaacaaat aaaggaattg tctcaaaatt gattttttct aatcaaattt ttattttgag
     1501 acattctcat ttttttgcat aagaaaatac ccaccaagct acggtttttc ttaccgctgt
     1561 tcggtgggta ttagtagtat tatgaaatct gaaaacttta agtattacta cttccgctaa
     1621 cgcaatcaca aaggtcgaaa gcttcaaagc gaaaataggc tttttactca tcaaacgtca
     1681 ccgtacctgc caacccgtcc accgttatca tttgtccgct cttaatagtt cgtgtggcaa
     1741 tgtgtgtagc cataacggct gggatgccat attcacgtgc gacaatgctt gaatggctaa
     1801 gaggaccacc aatgtccgtt acaatcgcac ttgcagatga aaataatggt gtccatgctg
     1861 gagttgtggt aactgcaacc aaaacacttc caggttgaaa gctttcaaaa tctgctggac
     1921 tattcagtac acaagctgga gccgtcacaa caccagtact ggtaccaatg cccgtcaaca
     1981 caattttccc atctttctgc ttctgttgtg cttgtgatat agtttttttg tttttctctg
     2041 gcaacttgga tggtgacata taacccatgt attttttaag ttcagctttt cgaacaggta
     2101 ttatcccgtt catatcagat agagacttgt ttttatccaa ctgctctata agtacctcca
     2161 attccgattt tgtgagccaa taaatatcat ctaaatgtga aatagctcct cctcgtatga
     2221 atcgttctga gatttcctga aacatacaac gaatcagagg atgtcccatt cccatcaaat
     2281 aaatagcatt ttcacgcata ggagaggttt cctgtgccca atggagcaac ttaaaaaata
     2341 gttttttacg caatccacct atgtgttgta aaatctcttc ttctgcatgt tttctacgct
     2401 tttcaaacgt ggtctggcgt aaaaaaggac tttccccttt tccttccaca aatgttttta
     2461 cggattcaaa agttggtgta agtgtttcct gcggtgtgga atgcgcaaaa tcaaactcat
     2521 aagcggtacg accaaactct ttaaagtact tattgattcg atttttccat tctatccata
     2581 cttcctgtga aactccaaca ggcacaactg aagacatgaa atcttctgct atctttattg
     2641 caggactgtt ttgcagataa aggttgatgc tgttattttg ctttacccat tctgaaatac
     2701 cccacaactc cttttccgat tgcagaacaa tcgtatcaaa cccaagcagg aaaacggaag
     2761 tatccgttat accagcacgt cgaactgctc cttgaaataa ttttgtaaat aatgtttcac
     2821 tgatagaagc agcaggcaat gtaagctgaa tccttgtgaa ataaatacat gcggcataaa
     2881 atattgtctg aataccctcc ataatttgat gggcgttcat agtatgcagg ggcttttctt
     2941 cccattgttt aatagcatcc tcatatcctt ttcgtgccgt ttcccagcgt gcaacgctgt
     3001 tcataagtgt cctacgtaaa gagcgtgggg aaagggattt gatagcaatc aaaagtggct
     3061 ttgatttagc agaaagataa acatatccat taataaccgt atatgccccg ttttttggta
     3121 ataatttttt cgcactttta ccaaacatat ctatccataa aagctctgat gcacggttta
     3181 cgatttcaag accaagtgtg gcgaacaaag gtgtaacagg atttggcaaa tgttctgcca
     3241 aacttccctt tgtgtataca acatcctgtt ctggcaatac ccattctggt ggcagaacag
     3301 taattggacg agcctgaaca atgtacaatt tatctttttc cagtgcccac tctacatcca
     3361 taggcatttg ataatacttc tcaattttct ttccaagctg tatcagttgc attacctgat
     3421 tacgagtaag agcatatttt tttctcaacc tttcaggaac catggtttct tctgttcctt
     3481 ctgaagtacg aaccgtcata atctctttat ttgccacttc atacgatata attcgttcgg
     3541 agtccttatc cactacgatt gtatcgggtg taactaagct agaaaccacc gcttcaccaa
     3601 gcccccatgc agcgttaata atcatttcgc tacgtctacc attgattggg tttaacgtaa
     3661 acataatacc agatgaatcg gaaaatgcaa gcttttgtac tacaacagca agtgcgacaa
     3721 tctcgtgctt tatattattc ttcacacgat aagcaatagc acgagctgtc cataaggaag
     3781 cccagcatct ctttacagag tcaataactt tatcttcacc ttgtatgtta agataagttt
     3841 cctgctgacc tgcaaaagaa gcgtcaggta aatcttcagc agtcgcagac gaacggacag
     3901 ccaccgatat gttccctaat ccagcataag ccattttaat tgcgtccgac acttcctgtg
     3961 gcatttctcc attatggaaa agctccccta ttttcttaga tacatcttca agttggctgg
     4021 tattattgga atcaatacca tctagcagtt tattaattcg agactgaata tggttcgtct
     4081 caacaaaaat ctggtatgaa gcagtcgtaa catgaaaacc gtctggcaca gggatgcctg
     4141 ctgtcaatag ttttgataaa gacatccctt ttccaccaac aatttcaatg gttgcttgtt
     4201 tatgttccag tggcaagaca taataaatca taatcattca cctccatcat tcataattcc
     4261 gttcagaaat atattcattg tttcatccaa cattttttcc gaactatcca atggtcgtga
     4321 cgtgtagctg attgataaca tggagttaat taacaaacgt gtcacaagag cggtatccgt
     4381 tttgcgaaag atgcctgtgg tcacaccatt atcaattacc gattttataa tatcttgata
     4441 tgcataacga gcatctttaa gtctctttcg atactcttct tctaaataat cagattctgt
     4501 atttaaccac atcagtacag ttctatactg ctctggaaat ctaagatgat taagcatgat
     4561 ttttctaagg cactgttgtg gtgaaggttc accatcaata atcctatgaa cttgttggat
     4621 agttttttct atttctttct caactgcata tacaacaatc tcgtctttcg ttttaaaaaa
     4681 atcgtataga cttgactttc ccatgttggc taaaactgca atttctctca ttgatgtttt
     4741 ttggaatcca ttttcagcca tgagactcaa agcaacagca actatttttt ctcggcgttc
     4801 tgcttgttgt tcgggtgtaa gcacaattcc ttttggcata gtgcgatacc tccttttagc
     4861 gaccactggt cgtttctttt ttatttatca tacagcaacc aacggtcact tgtcaaggtt
     4921 aatttttttc attgtatatg gtactcgaga taaaaatgtt cattttagaa attactctat
     4981 ttaagtagaa ataggcttca tcattagaaa gcaagactat aaatttgaga tatttatcat
     5041 gttcaaattt catcaatatc aaagtttaaa atattaataa aaaaagaatt actaagaaat
     5101 aacatataaa gattcaaaaa aggagttgaa cttaaaattc aattacaaaa aatcaaattt
     5161 aagacaactc ctttattctt tatctctact attctttatc tctatttatt tattacaact
     5221 ccctaacatt taccactact gccttaggtc tagtcatagc ctcaattgaa tacttaacac
     5281 cttgagttcc cataccagat gcctttacac ctaaaaatgg gaagtggtct ggacctcttt
     5341 cagtcttatt atttatttga acagtaccaa cttcaagttt atcagctata taaaatgcct
     5401 tatcaatatc acttgtaaat actgatgatt gaagcccata ctctgattga ttagcaattt
     5461 caattgcttg atttatatct ttaactctta taattggaag tactggacca aatggttctt
     5521 cccaagcaat tttcatatca acatttacat tatctaacaa tgttggatag aataaattat
     5581 tttttctaac attgcctgtt attaactttg ctcctttatg taatgcatca tcaaccaacc
     5641 cttgaacaaa atcagttgct ttattatcta taagaggagt gataactact tcatccattg
     5701 gatttccaat tgtcaacttc tctaccaatg gctttatttt tccgactaat ttatccgcca
     5761 cactctcttg tactaaaatt ctctttactg ccgtacatct ttgtcctgaa tatgaatacg
     5821 ctccagatac tatattctta gctgcaaaat ctaagtctgc atcttctaat actatagccg
     5881 catcttttcc accaagctcc aataataatg gtaccattcc agatatttta gatatatgct
     5941 gaccaacttc agtactacca gtaaagttaa taaaattaat tcctttatgc gttacaacat
     6001 aatcccctat ctcactaccc ctacctgtaa tagtattaag tactccatct ggtatcccag
     6061 cttttctcat aatttctacc acatgaagtg cgctaatagc cccttgtgta gcaggtttta
     6121 atacgactgc atttccacca ataagtgctg gagcaatctt tgacattgat aaatttacag
     6181 gataattaaa aggagatata gctaaaacag tacctaatgg aacccttgaa acataagaca
     6241 tcttatttct tgttccacca gggaaattat ctccactaat ggcttctccc tccatatttt
     6301 ttcccacatc agctgtgtat cttaaaaaat ctgctgttct ctcaacttct gcccttgcag
     6361 attttatgtc tttggctatt tcaagtacca gtatattagc tatctcatct atattttcta
     6421 acaataaatc agcagcctta tgaaatatat tgcctctctt gtatacaggc atttcagccc
     6481 atacttttat actctctttt gtgtttttta taacctcatc tacctcatgt tttgtcatag
     6541 attgtacttt cccaacaaga gaattatcta ttggtgagta aatttctatt ggctttctcg
     6601 aattagattc tacccatttt ccatttatta aatttttata tacattttct tttgttttaa
     6661 gttcattaaa catattttta ttcctctctc tgatataact ttgtgtattt aaattatagc
     6721 catttattcg ttatgtaaac atttcttttt ttcataaacg tttacctata aaaaaatttt
     6781 aagttaacgt ttttctacat tcttctattt taataacata ctcgctccaa atctatatag
     6841 gtcacacttt aatactaata tatcaatata ccaatatacc aatataccaa tataccaata
     6901 taccaatata ccaatatacc aatataaata ttataaacat aaatcacttg acaaatttat
     6961 aagtagacaa tattatatat ctatgactca aaatattttt aaagtcatat atatcatata
     7021 tagacagaaa ggattgataa aaatggctaa aagttttaca gaaatagaaa aagacaatat
     7081 aagaaaaaga ctaatttcag aatgtgaaat caactggtct aaatatggat acaaaaaaac
     7141 taatattgat gaactttgtt caaaatcagg aattgcaaag ggttctttct atacattttt
     7201 tgattcaaaa gaaaagttat tttttgaagt attaaatgga atccaaaaca gacttatatc
     7261 atcagtagat gaaattttaa gtaacatgcc tccaaaagaa ggctttgcaa aatccttaaa
     7321 aatgttatat cgattatatg ataaaaatcc atttttatat tcaccaaata atcctgattt
     7381 catcagccta ataaataaac tacctcaaga tatgttttta caacttgagt ccaataacat
     7441 acaaagtttt tacgacttaa ttgagagaca caatctcaag ttgaagatag aaaaagaaaa
     7501 agtttttggt gtttgtaatg ctctactatc aagtctgttg gtaaaagaaa atattgaata
     7561 taactatatt gaagtgtttg actttatggt ggataatctt gtagaacaca tacttgaata
     7621 acaatttaaa ataatttttc taagtatttt tttatactaa ataggattaa tatgattgaa
     7681 ttaatgcaaa aaataaacaa tataatttat aaaataaatg ataaactaaa tatcacacaa
     7741 aacttataga ccctagagca aacccattcc actctactct aagccatcta taatagtttg
     7801 tatatttcta ataatattag atattaaagt aagaaaaaaa ttccttataa taattgctat
     7861 tatatcaatt attgtaaatg ttttaataat cttagatagg taggtacata tatggtaaaa
     7921 tcctcgaaca cttttaataa aaacttcaac ttgatgatat taggtcaaat aatctcattg
     7981 tttggtgcat caatacttaa atttgcttta tctttataca tacttgatat aactggtaaa
     8041 gcagaaatat ttgctactat actagcagta tcttcaatcc caattatagt attctcccct
     8101 attggtggag ctattgcaga tatattcaac agaagaaact taatggttat ttttgatttt
     8161 tcaagtagtc ttacagtact aatcttagca gtattcttat tcaacaataa tggttcaata
     8221 ttacttgtag gaattattat gaccatatta tcagtcataa gcacaatgta tcaaccaact
     8281 gttcagtcaa gtacacccct tttagttgat aatgagcatt taatgaatgc aaatggtatt
     8341 gtagctggag ttgcatctct tacaaatatt gcaggacctg tattaggagg tgtcttgtat
     8401 ggtgtgattg gaattaatgc aattatagtt ataagttgtg taagtttctt tctatctgca
     8461 attatggaga tatttataca gattcctttt atcaaacaag agcaaaacag caacattata
     8521 aaaactatat ttactgatat aaaggatggt attgttcata tatgtaaaga aaatagattt
     8581 atactaaaaa tacttttttt agctatagca ataaacttat ttttaagctc tatgttaata
     8641 gttggtatcc cctatatagt aaaaatcact atgggagcta gtaacttctt atatggtcta
     8701 gcagaaggag caatttcttt tagttcactg gtagctgctg ttagtattgg tattttctca
     8761 aaacatctaa aaatcactaa tttgcatatt tcctttatta tatgtgcagt tatgttcata
     8821 ccaatggcgg tttcagtata tccatttata ttaaacacag gatttccagt tccattttta
     8881 atctttatag tatcatctat gctaatattt tttacaacga ctcttatctc aatatatgtt
     8941 ataacagtca cacaattaaa aactccaaat gaactcttag gaaaagtaat gtcaattctt
     9001 tttgcaggaa cagcaattgc aatgcccctt ggtcaggtta tgtatggtaa actttttgat
     9061 ttattatcag atagagtgta catcattata ctaggagttg gatttattac attacttata
     9121 gcatttgtat caaagataac attgaggaac gaaaatcttt agatacaaag aatttagata
     9181 taaagattta attttcacta atttctgaat ttaaatgcaa aattgtgtat cagtatgttg
     9241 acgttttaga aattgattga tataatcaat ggaaaataaa ctttataaaa attcaaaata
     9301 ttcagctaga ggagtgataa aaatgagtta catgccaact ttagaacaag catgggaaat
     9361 attaagaaaa tacaataagg aagaatttca tataagacat gctcaaattg tatctggagt
     9421 tatgagatac tatgcaaagg agtacgaccc tgaaagagta gaattttggg aaatagttgg
     9481 acttttacat gatttagatt ttgaaatgta tcctgatgaa cattgtgtta aacaaagaga
     9541 attaatgaca gagcttgatt tagataaatc aataatcgat tctacaataa gtcatggata
     9601 tggattaact ggttcagatg ttaaaccaga gcaatttatg gagaaagtat tatttgctgt
     9661 ggatgaactt actggtttaa ttggtgctgc tgcaataatg cgtccttcaa agagcgtttc
     9721 tgatttagaa ttaaaatctg ttaagaagaa atttaaagat aaatcatttg ctgctggctg
     9781 ttctcgagac gttataagaa gtggtgcaga aatgcttgga tgggaacttg ataagcttat
     9841 ccaaacaact atagaagcta tgagaagctt gattccagag atggcaatat agctcctcca
     9901 tacatatacc atagaagtta catctttaaa gagcatttct ctttttgatg caacttcttt
     9961 ttatattttg tagaataaaa agtttaatat tttaaactca ctatataata aataatataa
    10021 tgtataatag tcataaactt tctaacctta aaagtttcta ataatcaata aacaattcta
    10081 atatacaaat gtcattatat gatttaatta tatatctt
//
LOCUS       DAEHWM010000117        10095 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.120, whole genome shotgun sequence.
ACCESSION   DAEHWM010000117 DAEHWM010000000
VERSION     DAEHWM010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10095)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10095)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10095
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.120"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(32..1108)
                     /locus_tag="KNP36_003275"
     CDS             complement(32..1108)
                     /locus_tag="KNP36_003275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="HBF0875123.1"
                     /translation="MSKKLFIPGPIDVKEEVLQKMATPMIGHRGKDASMLQKSISEKM
                     QKLFYTNNTILLSTSSGTGLMEGSIRSCTSKKAAVFSCGSFGDRWYKMAVANNVPADI
                     FKVELGEATTPEMVDKVLSTGEYDLITVTHNETSTGIRNPIEEIGEVVKKYEDVIYCV
                     DTVSSAGGIKVEVDKIGIDICITSVQKALGLPPGMSICTFSQKAIDRAKQVPFRGVYL
                     DLLAMYEYLIKKNYQYPSTPSLSHMFALDFQLDNILDEGLDNRFNRHEDMANLVRNWA
                     KKHFQIFTNENHLSNTLTVIENTQGISVSNLNSKLQERGFQIANGYGDLKEKTFRISH
                     MGDYTVEDVQELLDNIDDILGFNK"
     gene            complement(1481..1996)
                     /locus_tag="KNP36_003276"
     CDS             complement(1481..1996)
                     /locus_tag="KNP36_003276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HBF0875124.1"
                     /translation="MDFLAKYKVLKKQNSSKSCLVCGTQNELGLKADFYELENGELVS
                     ICNTKDWHQSYPGRVHGGMSAAILDETIGRAVSINDDQIWGVTVSLELKYKKPVPTDA
                     TIKVVGRITKENRKLFEGTGEIILPNGDIAVTATGKYMKMPIGQIAEGDFSNEEWFFE
                     ESKEKVEYIEL"
     gene            complement(2359..3429)
                     /gene="leuB"
                     /locus_tag="KNP36_003277"
     CDS             complement(2359..3429)
                     /gene="leuB"
                     /locus_tag="KNP36_003277"
                     /EC_number="1.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="HBF0875125.1"
                     /translation="MNCNIAVIKGDGVGPEIIDEGIKVLNKICCKFNHRFDCEYVLAG
                     GCAIDETGEPLPNKTVETCRKNEAVLLGAVGGPKWDKCKGDKRPESGLLKLRESLGLF
                     ANLRPATMYESIKEASPLRTDIVEKGIDFVVVRELTGGIYFGERGRKIIDGIENAYDV
                     EIYNENEIRRIGKRAFEIARNRNKKLISVDKANVLESSRLWRSIMEDLAKEFEDVELS
                     HMYVDNAAMQVVKDPSQFDVIVTNNIFGDIISDEASMITGSIGMLPSASLREDSFGMY
                     EPIHGSAPDIAGKDIVNPIATILSVSMMLRHSFNLEEEAKCIEDAVQSVLNKGYRTID
                     IYNGVGNVVGTREMGELIVNEI"
     gene            complement(3436..3927)
                     /gene="leuD"
                     /locus_tag="KNP36_003278"
     CDS             complement(3436..3927)
                     /gene="leuD"
                     /locus_tag="KNP36_003278"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HBF0875126.1"
                     /translation="MIANGSVFKFGDNIDTDVIIPARYLNIADYKELATHCMEDIDDK
                     FISKVKKGDIIVATKNFGCGSSREHAPIVIKESGVSCVIASTFARIFFRNSINIGLPI
                     LECEEAANNIDEGDNIEVDFSTGVIKNITKGKEYKAEPFPEFMQNIILNEGLINSIKA
                     NRG"
     gene            complement(3942..5219)
                     /gene="leuC"
                     /locus_tag="KNP36_003279"
     CDS             complement(3942..5219)
                     /gene="leuC"
                     /locus_tag="KNP36_003279"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase large subunit"
                     /protein_id="HBF0875127.1"
                     /translation="MGMTMTQKILAKHAKLNEVKKGQLIEADLDVVLGNDITSPVAIR
                     EFEKLGIEDVYDKTKVVMVLDHFTPNKDIKSAEQCKFTRSFAKSKGVVNFFDVGDMGI
                     EHVLLPEKGIVTAGDVIIGADSHTCTYGALGAFSTGVGSTDMGAGMATGKCWFKVPGA
                     IKFVLKNKPNKWISGKDIILHIIGEIGVDGALYKSMEFCGDGVEYLSMDDRFTICNMA
                     IEAGAKNGIFPVDDKTMEYINSHKCSTMTKDVNIYEADEDAVYDEVYEIDLAELKETV
                     AFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLEVVAEIMKGKKVADGVRVMIF
                     PGTQKVYLEAIEKGYITTFIEAGAAVSTPTCGPCLGGHMGILAAGEKSISTTNRNFVG
                     RMGHVDSEVYLASPAVAAASAITGKISKPSEII"
     gene            complement(5176..6918)
                     /gene="leuA"
                     /locus_tag="KNP36_003280"
     CDS             complement(5176..6918)
                     /gene="leuA"
                     /locus_tag="KNP36_003280"
                     /EC_number="2.3.3.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-isopropylmalate synthase"
                     /protein_id="HBF0875128.1"
                     /translation="MKCGKYKKYDKMQIVNRKWPDNEIFKAPIWCSVDLRDGNQSLPT
                     PMSVNEKVRMFKMLIDTGFKEIEVGFPSASNTEYTFLRKLIDENMIPDDVTIQVLTQS
                     RAHLIEKTFESIRGCKKAIIHLYNSTSVLQRDVVFNMSKQEIIDIAVEGAKLFNEEVK
                     KYPETEFTFEYSPESFTGTEMDYALEICEAVIDVWKPTTQKKVIINLPSTVEMATPNV
                     YADQIEWFCKNISCRDSIILSLHTHNDRGTCTAASELGLLAGADRLEGTLFGNGERTG
                     NMDIVNVGLNLYTQGIDPELDFSNIDKIIGIYEDCTKLMVHDRHPYAGNLVHCAFSGS
                     HQDAIRKGMIAMKNRDNDYWEVPYLPIDPHDIGREYKEIIRINSQSGKGGAVYIMETD
                     YGFMIPKNMHSDFGNVVKMESDRIGEELSSEAIFNLFKKEYIEVESPYKVKKYKIKSM
                     DELNYENDDSNDTNMIEMTARISYMGNEQRIVGIGNGPVDSFNNALKQCGMKDYKFRY
                     YWEHALEEGSHSRGVAYVGIEHNNEVYFGVSISENINTAAINALMNAINKSYIEEEIK
                     NGDDYDAENISQTC"
     misc_binding    complement(7042..7288)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(7436..7882)
                     /locus_tag="KNP36_003281"
     CDS             complement(7436..7882)
                     /locus_tag="KNP36_003281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875129.1"
                     /translation="MSKNKFIYMNYYDNGYFKKGMTIYMVLALIILATIFIYSTTILY
                     ILCIITAVFLFKQGRDFSNKYEGKVYITLDNHSILINNQCIFSIKSKQSQKFNYKIIE
                     KIEVVKNILNIYTDESNYKIRLRALSLEDEKKLLNIIDEKMKKFKA"
     gene            complement(7903..8622)
                     /locus_tag="KNP36_003282"
     CDS             complement(7903..8622)
                     /locus_tag="KNP36_003282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase"
                     /protein_id="HBF0875130.1"
                     /translation="MKKSIMDVHCHTLISGHAHSTFKENVEEASKKNIKYLGISDHGP
                     NMPGGPHPFYFYNLHLLPREVQGVKILRGIEGNIMDYNGNLDVQEDMLQHLDYIIASL
                     HRPCIASGTKEENTNAILKVMDKPKVKIIGHPDDSRYPLDYEPIVKKAKDKNILLEIN
                     NSSLSSNSHRTGTWENVSHMLTLCKTYGARVILGTDSHICYSIGEFENAEKVLEAVDF
                     PDELVINYHEDEIIEFFDINF"
     gene            complement(8740..10014)
                     /locus_tag="KNP36_003283"
     CDS             complement(8740..10014)
                     /locus_tag="KNP36_003283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HBF0875131.1"
                     /translation="MFIMENDLTMQELLDQQEQVFSKVKVGELTTGKITAVRNDEVQL
                     GLDYGFDGIIPISELNIEKNQYIEDIYHIGDEITAVITKVSQKDGTITLSKLQLDKRN
                     DFAELQKAYDEHRIITVNVEKNIDKGVFANYNTYTFFIPISQLDTKFITDTSKFVGLN
                     LEVYIKELDVRKNRLVASHRDVLQERINKEREERRAQIKAEKEAERARIKQEREEEKA
                     RIKAAKEDLFNSLEVGQKRDGKVTKIMPYGAFVDIGGIEGLAHINNLAWTRVESVEDV
                     VSEGQEVEVYVLDVNKETKKIALALKDINNDPWDLIAKEVQIDDVVNVKVLRIIEKGA
                     FVQIKEGVDAYLPISELSDTRVAKVTNVVNIGDEVKVKILDFKPKTKRMLVSIKEATR
                     EPEEDITEYLEVEESLGSIGELFKDKFKDLEV"
BASE COUNT         3050 a         1955 c         1062 g         4028 t
ORIGIN      
        1 tttatcttaa aacatacata tttttacaat attatttatt aaaacctaat atatcatcaa
       61 tattatctaa taattcttgt acatcttcga cagtatagtc acccatatgt gaaattctaa
      121 aagttttttc ttttaaatct ccatagccat ttgctatttg gaatcctcgt tcttgtaatt
      181 ttgaatttaa atttgataca ctaatacctt gagtattttc tataacagta agtgtattgg
      241 ataagtgatt ttcattggta aaaatttgga agtgtttttt agcccagttt ctaactaagt
      301 ttgccatgtc ttcatgtctg ttgaatctgt tatctaggcc ttcatctaat atattatcta
      361 attggaaatc taaagcgaac atgtgagaaa gagatggtgt tgaagggtat tggtagtttt
      421 tcttgattaa gtattcatac attgctaaca aatcaagata tactcctcta aaaggtactt
      481 gcttagctct atcgattgct ttttgagaaa atgtgcaaat agacattcct ggtggtaatc
      541 ccagtgcttt ttgtactgat gttatacaaa tatctattcc aatcttatca acctcgactt
      601 ttattccacc ggctgaactt acagtatcta cacagtagat tacatcctca tactttttaa
      661 caacttctcc aatttcttct attggatttc ttattccagt tgaagtttca ttgtgagtta
      721 cagttattaa atcgtattct ccggtagaaa gcaccttatc aaccatttct ggcgttgttg
      781 cctctcctaa ttcaacttta aatatatccg ctgggacatt attagccact gccattttgt
      841 accatctatc accaaaggat ccacaggaaa atactgctgc ctttttggat gtacaggaac
      901 gaatggagcc ttccattaaa ccagttccgg atgacgtgga taaaagtatc gtgttgtttg
      961 tatagaatag tttttgcatc ttttcactta tactcttttg gagcatagat gcatcttttc
     1021 ctctatgtcc tatcattggt gtagccatct tttgcaagac ttcttcttta acatcaatag
     1081 gaccaggaat aaataatttc ttactcatta taattccccc ctttttagtt tgtaatatgg
     1141 atagcgtttt tactgtcctt atttttaata actataatat caagctgaat taactatgtc
     1201 aacataaaat ttatttttta tatataattt attttatata ttttatgaaa acattcattt
     1261 tctacctttt cataagtctg aattttctga attattccct caaaaaaaat atacttttta
     1321 tctatataaa ttaatttttt tagtatgtaa attttacgct attacgataa atctttttag
     1381 tataactaat ttatttttat cttgtatttt tattgtattt ttgaatttta ttttttctaa
     1441 atataaaatt tatgttttaa aatataaaat ttttatttaa tcaaagttca atatattcca
     1501 ctttttcttt cgattcttca aaaaaccatt cttcattaga aaaatcacct tctgcaattt
     1561 gtccaatagg cattttcata tactttccag ttgctgtcac tgctatatct ccatttggta
     1621 gaattatttc tcctgtacct tcaaataatt ttctgttttc tttagttatt cttccaacaa
     1681 cttttatagt agcatctgtt ggtactggtt tcttatattt caactctaaa gatactgtta
     1741 ctccccatat ttggtcatca tttatactta cagctcttcc aatagtctca tccaatattg
     1801 cagcagacat acctccatga actctcccag gataactttg atgccaatcc tttgtattac
     1861 aaattgatac aagctctcca ttttcaagtt cataaaaatc tgctttaagt cctagctcat
     1921 tttgtgttcc acaaactaaa caagatttac tactattttg cttcttcaaa actttatact
     1981 ttgccaaaaa atccatctcc taaccgacat tagtagtcgc ttaatattaa ataattctaa
     2041 aatatattat ataatattaa taaaatccct gcaaacttct aataataaaa ataggctact
     2101 tcaatatgat aagtttaatt taaagtatta ttttccaaaa aataacttta tcaaaataga
     2161 aactcaaagt agatataaac ctctttttcg ttattaaaat agtaaaaata tatttgactt
     2221 aatataaaaa agagtgtctc attaactaat aaagtttatt ttgagacacc cctcataaaa
     2281 caaattatac tacaatagat ttttactaat tctacaagtt atatatttaa attatattat
     2341 tcaaattaaa ctataattct aaatttcatt tactattaat tcgcccattt cccttgttcc
     2401 tacaacattt cccacaccat tatagatatc aatagttcta taacctttat tgagtacact
     2461 ttgtacagca tcttcaatac acttagcttc ttcttctaag ttaaaactat gtcttaacat
     2521 catgcttaca gatagaatag tcgcaattgg atttacaata tcttttccag ctatatcagg
     2581 tgcacttcca tgtattggtt catacatacc aaaactatct tctctaagtg atgctgatgg
     2641 taacatacct atagaacccg taatcataga tgcttcatca gatattatat ctccaaatat
     2701 attattagtc actattacat caaattggct agggtctttt acaacttgca tagcagcatt
     2761 atcaacatac atatgtgaca gttctacatc ttcaaactct ttagctaagt cttccattat
     2821 acttctccaa agtcttgaac tctcaagcac atttgcctta tctacactta taagtttttt
     2881 atttctattt ctggctattt caaaagctct cttaccaatt cttcttattt cattttcgtt
     2941 atatatttct acatcataag cattttcgat accatcaatg atttttcttc cacgttctcc
     3001 aaaataaatg ccccctgtta attcccttac aacaacaaaa tcaatgcctt tctcaactat
     3061 atccgttcta agtggtgaag cttcttttat actttcatac attgtagctg gtcttaaatt
     3121 tgcaaataaa cccaatgact ctcttaattt taaaagacca gactctggtc ttttatctcc
     3181 cttacattta tcccactttg gtcctccaac agcaccaagc aatacagctt cgttttttcg
     3241 acaagtttca acagttttat taggtagagg ttctccagtt tcatcaatcg cgcatcctcc
     3301 agctaataca tattcacaat cgaatctatg attaaattta caacaaattt tatttagaac
     3361 ctttatacct tcatctataa tttccggtcc aacaccatca ccttttatga ctgctatatt
     3421 acaattcata cttcactacc ccctatttgc ttttattgag ttaattaagc cttcatttaa
     3481 tataatattt tgcataaact caggaaatgg ttctgcttta tattcttttc cttttgttat
     3541 attttttatc acacctgtag aaaaatctac ttctatatta tccccttcat ctatgttatt
     3601 ggcagcttct tcacattcaa gtataggaag ccctatattt atagagtttc taaaaaatat
     3661 tctagcaaaa gtagaagcaa tcacacagga tactccactt tcttttatta caattggtgc
     3721 atgttctctt gatgaaccac aaccaaagtt tttagttgca actataatat ctcctttttt
     3781 taccttagaa ataaatttat catcaatatc ctccatacaa tgcgttgcta gttctttata
     3841 atcagctata tttaaatatc tagctggtat tattacatct gtatctatat tgtcaccgaa
     3901 tttaaaaaca cttccattgg caatcataaa ttttacctcc cttaaattat ttctgatggt
     3961 tttgatattt ttccagttat agctgatgct gctgctacag ctgggcttgc aagatacacc
     4021 tctgaatcaa catgccccat tcttcctacg aaattcctat ttgttgttga aatggatttt
     4081 tctcctgctg caagtatacc catatgtccc cctagacatg gaccacaagt tggtgtagaa
     4141 actgctgctc ctgcctctat aaaagtggta atataccctt tttctatagc ttcaagatat
     4201 actttttgag ttccaggaaa tatcataact ctaactccat ctgctacttt tttgcctttc
     4261 attatctcag ctactacttc aaggtctgat attcttccat ttgtacaaga gcctattaca
     4321 acttggtcta tctttatatc cttatctatc tcatctactg ttctagtatt ttcaggaaga
     4381 tgaggaaagg ctactgtttc ttttagttca gctaaatcta tttcgtatac ttcatcatag
     4441 actgcatctt catctgcttc atatatattt acatcttttg tcatagttga acacttatgt
     4501 gaatttatat attccatagt cttatcgtct actggaaaaa ttccattttt tgctcctgct
     4561 tctattgcca tattacaaat agtaaatcta tcatccatag ataagtattc tactccatct
     4621 ccacaaaatt ccattgactt gtaaagtgct ccatcaacac ctatctcccc tattatatga
     4681 agtattatat ctttaccact tatccattta tttggtttat tcttcaaaac aaattttatt
     4741 gctccaggaa ccttaaacca acattttcct gtagccatac ctgctcccat atcagttgaa
     4801 cctacaccag tagaaaatgc tcctaatgct ccatatgtgc aagtatgaga gtcagcacct
     4861 ataattacat ctccagcagt tactatacct ttttcaggaa gaagaacatg ctctattccc
     4921 atatctccta catcaaaaaa atttacaact ccttttgatt ttgcgaaact tcttgtaaat
     4981 ttacattgtt ctgcactctt tatatcttta ttaggtgtaa agtggtctaa aaccatcact
     5041 actttagtct tatcataaac atcttcaatt cctaattttt caaattctct aatggctact
     5101 ggtgatgtta tatcattacc taaaactaca tctaaatctg cttcgattaa ttgccctttc
     5161 ttaacttcat ttaatttagc atgtttggct aatattttct gcgtcatagt catccccatt
     5221 ttttatttcc tcctcaatat aacttttatt tattgcattc ataagtgcat taatagctgc
     5281 tgtatttatg ttttccgata tacttacacc aaaatagact tcattattgt gctctattcc
     5341 tacataagct acccctcttg aatgtgaccc ttcctctaat gcatgttccc agtaatatct
     5401 aaatttataa tctttcatgc cacattgctt tagtgcatta ttaaatgaat ctacaggtcc
     5461 atttcctata ccaacaatcc tttgttcatt tcccatataa cttattcttg cagtcatctc
     5521 aatcatgtta gtatcattag aatcatcatt ttcatagttt aattcatcca ttgattttat
     5581 tttatacttc ttaactttat aagggctctc aacttcaata tattctttct taaacaaatt
     5641 aaatattgct tcactactaa gttcttcccc aattctatca gattccattt tgactacatt
     5701 tccaaaatca gaatgcatat tcttaggtat cataaatcca taatctgttt ccattatata
     5761 aacagctcct ccttttccag attggctatt tatccttata atttctttgt attctcttcc
     5821 aatatcatga gggtctattg gtaaatatgg aacttcccag taatcattat ctctgttttt
     5881 cattgctatc atgccttttc taatagcatc ttgatgtgaa cctgaaaaag cacaatgtac
     5941 aagattacct gcatatggat gtctatcatg taccataagt tttgtacaat cttcatatat
     6001 acctattatc ttatctatat tgctaaaatc tagctctggg tctattcctt gtgtataaag
     6061 attaagtccc acatttacta tatccatatt cccagttctt tcaccatttc caaatagtgt
     6121 tccttcaagt ctatcggcac cagccaataa tccaagttca cttgcagccg tacaagttcc
     6181 tctatcattg tgagtatgca aacttagtat aatagaatcc ctacaactta tatttttaca
     6241 aaaccattct atttggtctg catatacgtt tggtgttgcc atttcaactg ttgatggaag
     6301 atttattatt actttttttt gagtagttgg tttccaaaca tctatcactg cctcacatat
     6361 ttcaagtgca taatccatct ctgttcctgt aaaactctct ggtgaatatt caaaagtaaa
     6421 ttctgtttct ggatattttt ttacttcttc attaaataat tttgctcctt caactgctat
     6481 atctattatt tcttgtttac tcatattaaa aaccacatct ctttgaagaa cagatgtaga
     6541 gttatataaa tgtataattg cttttttaca tccccttatt gattcaaatg ttttttctat
     6601 aagatgagcc ctagattgtg taagtacttg tatagttaca tcatctggaa tcatattctc
     6661 atctattaat tttcttaaaa atgtatactc tgtatttgat gctgatggaa atcctacctc
     6721 tatttcttta aatcctgtat caataagcat tttgaacatt ctgacttttt catttacact
     6781 cataggtgtt ggcagtgact gatttccgtc tcttaaatcg acactacacc aaattggagc
     6841 cttaaatatt tcattatctg gccatttacg atttactatt tgcattttat catatttttt
     6901 atactttcca cacttcatgt tatttccccc tttttctgtt ttttgtattc agtatacctc
     6961 atatcgacgc aatcctgcac aattcataag gataaatgtc aattttatca ttagaataaa
     7021 aaaaacctca tctctaataa aattagagac gaggttttgc tcgcggtacc actctattta
     7081 gctttctaaa aagctccctt agtaatagcc aatacaataa ttataatgac tatatttcct
     7141 ataacgtgga attactccga ttattctaag atttaaatct tagaaaacag ctcctagaca
     7201 agttcagaac tatcaactac taaatcacac catcctttag ctctctgaaa gtttcattgt
     7261 tcttactact tctattcatc acttttttaa tcatttaaat tttctaaata ttttgattta
     7321 atagttatta tatacacatt aaaatgtatt gtcaacacaa aaaataatta tctcaatttt
     7381 ttatttttga taagcaattc tataaaacat gctaactatt gaaaacagta tgatattatg
     7441 ccttaaactt tttcatcttt tcatctatga tattcaataa ttttttttca tcttccaaac
     7501 tcaatgccct taatctaatt ttataattag attcgtcagt gtatatattt aatatatttt
     7561 ttactacttc tattttttct attatcttat aattaaactt ttgactttgt ttagatttta
     7621 tactgaatat acattgatta tttattaata ttgaatgatt atcgagagta atatatactt
     7681 ttccctcata tttatttgaa aaatcacgac cttgtttaaa tagaaaaact gctgttatta
     7741 tacataaaat atataatatt gtcgttgaat atataaaaat tgtagctaaa attataagtg
     7801 ctaaaaccat atatatagtc attccttttt taaaataacc attgtcataa taattcatat
     7861 agataaactt atttttactc aaattttttc acttccaaga ttctaaaaat ttatatcaaa
     7921 aaattctata atttcatctt catgataatt tatgactaat tcatctggaa aatctactgc
     7981 ttctaaaact ttttctgcat tttcaaattc tcctatagaa taacatatat gagagtcagt
     8041 accaagaatt actcttgcac catatgtttt acacaatgtc aacatatgac ttacattttc
     8101 ccaagtaccc gttctatgag agtttgaact taatgatgaa ttatttattt ctaaaaggat
     8161 atttttatct ttagcttttt ttactatagg ttcataatct aaaggatacc tactgtcatc
     8221 tggatgtcca attattttta ccttaggttt atccataact tttaaaatag catttgtatt
     8281 ttcttctttt gtaccagaag ctatacaagg tctatgcaaa cttgcgatta tataatccaa
     8341 atgttgcaac atatcttctt gaacatctaa attaccatta taatccatta tatttccttc
     8401 tattcctcta agaatcttta cgccttgcac ttcacgtgga agcaaatgca aattataaaa
     8461 atagaatgga tgtggtcctc ctggcatatt aggtccatgg tctgatattc ctaagtattt
     8521 tatattcttc ttactcgcct cttcgacatt ttccttgaaa gtactatgtg catgtccact
     8581 tattagagtg tgacaatgta catccataat agactttttc attaaatttc ctcctaatat
     8641 tttacataaa ttcgtgaaaa tagctaaagg gctatttcaa aactaaagct gtcataatag
     8701 acagtgtaac gttttaaaac agccccattt tcaattattt tacacttcta aatctttaaa
     8761 tttatcttta aataattctc caatacttcc taaagattcc tctacttcta ggtattctgt
     8821 tatatcctct tctggctctc tagttgcttc ttttattgaa accaacattc tcttagtctt
     8881 tggtttaaaa tcaagaatct taactttaac ctcatctcca atattaacaa cattagtaac
     8941 tttagccact ctagtatcac tcaattcaga tattggtaaa tacgcatcta caccttcttt
     9001 aatttgaaca aaagcccctt tttctattat tctaagaact ttaacattga caacatcatc
     9061 aatttgtact tcttttgcta ttaaatccca agggtcatta tttatgtctt ttaatgccaa
     9121 ggcaattttt ttagtctctt tatttacatc caacacataa acttctactt cttgtccctc
     9181 tgaaacaaca tcttcaacac tttcaactct tgtccaagct aaattattta tatgtgctaa
     9241 tccttcaatc ccaccaatat ccacaaatgc accataaggc attatctttg tcaccttacc
     9301 atctcttttt tgtccaactt caagagaatt aaataagtct tctttagctg ctttgatacg
     9361 agctttttct tcttctcttt cttgcttaat tcttgctctt tcagcttctt tttctgcctt
     9421 aatttgagct cttctttctt ctctctcttt atttatacgc tcttgtaata catctctatg
     9481 agatgctaca agtctatttt ttctaacatc caattctttt atataaactt ctaagttaag
     9541 accaacaaat ttagatgtat ctgtaataaa ttttgtatca agttgagaaa ttggtataaa
     9601 aaatgtatat gtattgtaat tagcaaatac acctttatct atattctttt caacatttac
     9661 agttattatt ctatgttcat cataagcctt ttgtaactcg gcaaaatcat ttcttttgtc
     9721 aagttgtaat ttagataaag ttattgtacc atctttttga gatacttttg ttattacagc
     9781 agttatttca tcacctatgt ggtatatatc ttctatatat tgattttttt ctatgttcaa
     9841 ttcacttata ggtattattc catcaaaccc atagtctaat cctaattgta cttcatcatt
     9901 tctcactgca gttatttttc cagttgtcaa ttctccaact ttcactttgc tgaatacttg
     9961 ttcttgctgg tcaagtaatt cttgcattgt taaatcattt tccattataa acatcctttc
    10021 ctcttattga ttatcatatc tgtaaatatt ataccattaa tattgcaaat acttacattt
    10081 ttcttactat aattt
//
LOCUS       DAEHWM010000118        10014 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.121, whole genome shotgun sequence.
ACCESSION   DAEHWM010000118 DAEHWM010000000
VERSION     DAEHWM010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 10014)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10014)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10014
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.121"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1136
                     /locus_tag="KNP36_003284"
     CDS             <1..1136
                     /locus_tag="KNP36_003284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0875132.1"
                     /translation="EGNKILIHISQVLNNNTNKYEICARMDNDHFILLIACNTEDELL
                     NRLSKINKEICNLNTTNSSKYKIVMSSGIYKITKKDDIKKIDLLIDRANIAAKSKKEK
                     YEHSYSFFNEDTRNRLYKEKRLEDNMNKALEKGEFIVYYQPKYSLDDVNEIEGAEALI
                     RWNSPEFGFISPIDFVPLFEKNGFIVNIDMFVFEEVCKTLNKWINKGYTPVPISVNMS
                     RVHLYRDNFIENITDLISKYNISPEFIELELTESVVFDNLNILIDIMKKIKEIGFLIS
                     MDDFGSGYSSLNLLKDLSFDILKLDRGFLIETTDTKRGKIIISKIVEMAKAIDIKVIC
                     EGVETYEQVEFLKEIGCDKVQGYLFAKPMVLDEFEKHLNFKFD"
     gene            1283..2029
                     /locus_tag="KNP36_003285"
     CDS             1283..2029
                     /locus_tag="KNP36_003285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875133.1"
                     /translation="MNILSIRNISKTYCGNIPFKALDKVSLNIEKGEFVSVMGPSGSG
                     KSTLLNIISTVDRQSEGEVVLDGYDVSKLKGEKLAEFRRKQLGFVFQDFNLIDTLTVG
                     ENIMLPLTLEGASIKDMNIQTKSISKFLGIDKILDRKTYEISGGQAQRCAIARAIINK
                     PAILLADEPTGNLDSKSTDDVLKLFTRINKEQKVTTLMVTHEAYSASYSDRVIFIKDG
                     CIYTEIKKSESSNSFYSDILAVLSQIGGVR"
     gene            2029..3909
                     /locus_tag="KNP36_003286"
     CDS             2029..3909
                     /locus_tag="KNP36_003286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875134.1"
                     /translation="MDFRKFAYNNIVKNFRAYLAYFLSSVFSIMIFFVFAVSMFHPII
                     TKSGMQSGSTAFMALMTSELIIFGFSLLFILYSLGNFLKYRLKDFGVLMIIGMSNRQL
                     KKLILIENLIIGFLAVMLGILLGLSISKLFLLYLSKLFYMNLTEFYFPVKAMLLTIVS
                     FMILFLITGPMSLKLLSKKSILELLVGTKKPKKEIKSSKLFGIIGVICLILGYAMILF
                     GNKLKINGGMYTTALLITLGIFLFFSQFTILILKYLKNKEKFYKNKVNMLLISNLIYK
                     LKDNTRLLFLITILLSATLVAFTTTSTLVSSQGEASKNNFPMVYSYFSEHNNEKEYEE
                     LQQIREAIKGYDYKELSFPVLKYNREVLLSVKNYNKLSKELGLDKISSKLEKYEGVII
                     PSSNSQEHINSLKQLKNYSIKNLNIEVKKSKNKIIFPTGLFSKVVVISDDLYNEVKGE
                     FSKINFHGFDYKNWQSSAQITENLKEKHFNLDREYNRSYFLTLPDMYLVELQQSKILQ
                     FMGVFIGVILFIAVFSFLYFRLYTDEIEDNVKYKKLSKIGLSFKNMNKIVSIEIGTLF
                     FIPYFIAIINSIISLLFLNQVLNNSFKLENLGILLLISSIYSLYFYLLKKIYTRKVWF
                     FD"
     gene            4028..5419
                     /locus_tag="KNP36_003287"
     CDS             4028..5419
                     /locus_tag="KNP36_003287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0875135.1"
                     /translation="MENQQLLGTERISKLLLKYSIPAIIGMLVNSLYNVVDRIFIGNI
                     PGVGPLAITGLGVTMPIMTIILAFGMLIGIGTTTTISIKLGQGKVEEARKLIGNAMTL
                     SVITGIIIMILGILFANKILTLFGASENTLIYAKSYINIILLGTVVNLLSFSLNHSIR
                     ADGSPKISAGIMIVGCLTNIVLDWILIFGFNLGIQGAAIATVTSQALTAILTIGYYIS
                     GKSNLRFSKSNLKLDKKLIKAVFAIGMSPFAMQLAASLVQVISNIALKTHGGDLAIGA
                     MATISSIAMVFLMPIFGINQGAQPIIGFNYGAEKYDRVKKAYLGSLVVATIILCMGMV
                     VVMLFPEAIIGIFNKDPELMNISVNGLRIYLLMLPIVGLSVTGTNFIQSIGKAKMAML
                     LSLLRQVILLIPAVLILPTFLGLQGVWTAQPVSDFIATVITGIVVFRELKRYTPKTEK
                     LNENERLNEITTE"
     gene            5526..6566
                     /locus_tag="KNP36_003288"
     CDS             5526..6566
                     /locus_tag="KNP36_003288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBF0875136.1"
                     /translation="MEFTKKSKLKNMYVNMNVARMLSKINEYKGRQLLYKKQPKEILE
                     NLEKKSLVDCSESTYIGNQRDSSNFNLEKLISNEVTPRSREELSIVEYRDVVKTINSA
                     YESIPISSQTILELHGYLYKFSSTRGGSYKSDNDFIEHNLKPSEFISIDSSVNKVEKA
                     VEEICEAYNTLIEEDEIDILILISAFVLDFILIHPFKEGNIKMARVLILLLLNKNGYE
                     VGRYISLGKIFDDSSYEYYSNLNYLKASIGSEKADMNAWIEYFLETILTAYEKLDDSL
                     NISDKKRQTKTSRIEKIINSTLGYFTKEDIRDLCPDIPEPTINRVFNNLRKQDKIEVV
                     ARGRSAKWKKKY"
     gene            7055..7708
                     /locus_tag="KNP36_003289"
     CDS             7055..7708
                     /locus_tag="KNP36_003289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HBF0875137.1"
                     /translation="MKKKLLYINVNSKPEDLSSSKTVARKFINKFMEKNKDFEVEEID
                     LYKEHIPRLEYQYFEKRNSIVSEENAKNLDDKDRKELTKIRNLCDQFVSASVYVIAAP
                     MWSLSFPAPLKEYIDCIIQDGKTISFEGNDKPQGILNDIDRSMVYIQSSGGHIPWVLK
                     PVMNKGLNYVESIMKFIGIKKFDELLVDGTGTSEEERQAAIEKAAEKIDGIIDGMKF"
     gene            7784..7993
                     /locus_tag="KNP36_003290"
     CDS             7784..7993
                     /locus_tag="KNP36_003290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875138.1"
                     /translation="MREEKSNEKYDCYWCNQENNFCVEIKDNIVMIDDGTGTLKQAVF
                     IGYKQIQINLNCSHCQNLNRIKLNL"
     gene            complement(8133..8699)
                     /locus_tag="KNP36_003291"
     CDS             complement(8133..8699)
                     /locus_tag="KNP36_003291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HBF0875139.1"
                     /translation="MMNNELNTIILETLNNADITSNDIPSIDLYMDQIISLIDNKLSA
                     NKRFESDKILTKTMINNYSKEGLIKPVKGKKYTKEQILQMIIIYSMKNTLTIQEIKRI
                     LHGVYEKDNFSEKDLVSCYEKFMLIKENQRKNIPDFIESNFENISINPENKDDLLIAL
                     LSLTSMADQLKNISEKLVDRYFPDITKK"
     gene            8860..9513
                     /locus_tag="KNP36_003292"
     CDS             8860..9513
                     /locus_tag="KNP36_003292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HBF0875140.1"
                     /translation="MYQFFLKGRDPISSLTHFIGACLSLLATIILVFQSVTLQETSLL
                     MIVSVSVFGFSLIALYSASSYYHFLKGTPEQELFFRKVDHAMIYVLIAGSYTPICLNF
                     MEKKEGIIFVTAIWIVAFIGIIIKIFWMDAPRWLSTSIYLLMGWAIVFDINAFNSIPK
                     DCLRLLIMEGVSYSIGAIIYIIKKPNISPEFGFHEIFHIFIMIGSLFHFLAVLLYVL"
     gene            complement(9671..9847)
                     /locus_tag="KNP36_003293"
     CDS             complement(9671..9847)
                     /locus_tag="KNP36_003293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875141.1"
                     /translation="MYKYDDYVNLTNDLDLPVEIRNKCVRIVSVSENLEDIIIVHKFK
                     LYVVNEKYIKGIME"
BASE COUNT         3897 a          995 c         1598 g         3524 t
ORIGIN      
        1 ctgaagggaa taagatatta attcatatat cacaggtttt aaataataat acaaataaat
       61 atgaaatttg tgctaggatg gataatgacc attttatatt gttgattgct tgtaacactg
      121 aagatgaact tttaaataga ttatctaaaa taaataaaga aatttgtaac ttaaatacta
      181 ctaactcatc taagtataaa attgttatgt caagtggaat atataagatt actaaaaagg
      241 atgatattaa aaagattgac ttgttaattg atagagcaaa tattgcagca aaaagtaaaa
      301 aggaaaaata tgaacattca tattcatttt ttaatgaaga tacaagaaat cgattgtaca
      361 aggaaaaacg attggaagat aatatgaata aagctttaga aaaaggtgaa tttatagtat
      421 attatcaacc taagtatagt ttagatgatg taaatgaaat tgaaggagca gaagccttga
      481 taagatggaa tagtccagaa tttgggttta tttcacctat agattttgta cctttatttg
      541 aaaagaatgg ttttattgta aatattgata tgttcgtgtt tgaagaagta tgcaaaacat
      601 taaacaagtg gataaataaa gggtatactc ctgtaccaat ctctgtaaat atgtctagag
      661 ttcatttata tagggataat tttatagaaa atataactga tttgataagt aaatacaata
      721 tatctcctga gtttattgaa cttgaactaa cagaaagtgt tgtgtttgat aatttaaata
      781 tattgattga tataatgaaa aagattaaag agataggatt ccttatatca atggatgatt
      841 ttggttcggg atattcatct ttaaatctgt taaaagacct ttcttttgat attttaaaat
      901 tagatagagg atttttaatc gaaacaacag atacaaaacg tggaaaaatt attatttcta
      961 agattgtgga aatggcaaaa gcgattgata ttaaagtaat ctgtgagggc gtagaaactt
     1021 atgaacaagt agagttcttg aaagagatag gttgtgataa ggttcaagga tacttatttg
     1081 ctaaacctat ggtattagat gaatttgaaa aacacttaaa ctttaaattt gattaatcat
     1141 taataattat tagactataa tataccctaa caacttactt acaaatatgt aagttaattg
     1201 ttagggtatt tttatggtta aagtagtata ttcacgatat tatggtattg tagtaaaaat
     1261 aaaaaattat ggagaatata aaatgaacat attgagtatt agaaatatat caaaaacata
     1321 ttgcggaaat attccattta aagcattaga taaggttagt ctaaatatag aaaagggaga
     1381 atttgtgtct gttatgggac catctggaag tggtaaatct actcttttaa atataatatc
     1441 tacagttgat agacagagtg aaggtgaggt tgtattagat ggatatgatg taagtaaatt
     1501 gaaaggagaa aaacttgctg aatttagaag gaaacaactt ggttttgtat ttcaggattt
     1561 taatttgatt gacactttaa ctgttggcga aaatattatg ttgccactta cactagaggg
     1621 ggcaagtatc aaagatatga atatacaaac taaaagtata tctaaatttt taggaataga
     1681 taaaatttta gatagaaaaa cctatgaaat ttcaggaggt caagctcaaa ggtgtgctat
     1741 tgctagagct attataaata aacctgccat acttcttgca gatgagccaa ctggaaatct
     1801 tgattcaaaa tctactgatg atgttttgaa attatttact aggataaaca aagaacaaaa
     1861 ggtaacaaca cttatggtaa ctcatgaagc atatagtgca agttattcag atagagtaat
     1921 ttttataaaa gatggttgta tatatacaga aataaaaaaa tctgaaagca gtaattcttt
     1981 ctattctgat atactagctg ttttgtctca aataggaggt gtaagatagt ggattttaga
     2041 aagtttgctt ataataatat agttaaaaat ttcagggcat atttagcata ttttttaagt
     2101 tctgtttttt ctataatgat attttttgtt tttgcagtgt ctatgttcca tccaattata
     2161 acaaaatctg gaatgcagag tggttctact gcatttatgg ctcttatgac ttcagaatta
     2221 ataatattcg gttttagtct actttttata ttgtactctt taggaaattt cttgaaatat
     2281 agattgaaag attttggagt attgatgata attggaatga gtaacagaca actgaaaaaa
     2341 ttgatattaa ttgaaaattt gataatagga tttttagcag tgatgttagg aatattactt
     2401 ggtttatcaa tttcaaaatt gtttttattg tatttaagca aactgtttta tatgaattta
     2461 actgaatttt attttccagt aaaagcaatg ctattgacta ttgtatcatt tatgatttta
     2521 tttttgataa caggaccaat gagcttaaaa ttattgagta aaaagagcat tttagagctt
     2581 ttagtaggta caaaaaagcc taaaaaagag ataaaatctt caaagctatt tggaataatt
     2641 ggtgtaatat gtcttatatt aggatatgct atgatactat ttggcaataa gttaaaaata
     2701 aatggaggta tgtatacaac agcactatta attactttgg ggatattttt atttttttct
     2761 caatttacta ttttgatatt aaagtattta aaaaataaag aaaaatttta taagaacaaa
     2821 gtaaatatgt tacttataag taatttgata tataaattaa aggataatac acgattgtta
     2881 tttttaataa caatactttt atcggctact ttagtagcat ttacaacaac ttcaacactt
     2941 gtaagttctc aaggagaagc ttctaaaaat aattttccaa tggtttactc atatttttca
     3001 gagcataata atgaaaaaga atatgaagaa ctacaacaaa ttagagaagc aatcaaagga
     3061 tatgattata aggagttaag ttttcctgta cttaaatata atagggaagt cttactaagt
     3121 gtaaagaatt ataacaaatt atcaaaggaa ttgggattag ataaaattag ttcaaagtta
     3181 gaaaaatatg aaggggttat aattcctagt agcaattcac aagaacatat aaattcttta
     3241 aaacaattaa aaaattatag tataaaaaat ttaaatatag aagtaaaaaa atcaaaaaat
     3301 aaaataattt ttcctacagg actgtttagt aaagttgtag ttataagtga tgacttatac
     3361 aatgaagtaa aaggtgaatt ttcaaaaatt aattttcatg gatttgatta taaaaactgg
     3421 caaagcagtg cacagataac tgaaaattta aaagaaaaac attttaattt ggatagagaa
     3481 tataacaggt catatttttt aacattacca gatatgtatt tagtagagtt acaacaaagt
     3541 aaaattcttc aatttatggg tgtttttata ggagtgatat tatttatagc agtttttagt
     3601 tttttatact ttagattata tacagacgag atagaagata atgtaaagta caaaaaacta
     3661 tcaaaaatag gtctatcttt taaaaatatg aataagattg ttagtataga gataggtaca
     3721 ttgtttttta taccgtattt tatagcaatt ataaatagca taatttcttt actgttttta
     3781 aatcaagtat taaataatag ttttaagtta gaaaatttgg gtatattact actgatatca
     3841 tctatatatt cactttattt ttacttatta aaaaaaattt atactagaaa agtttggttt
     3901 tttgattaaa gtggtatata atagatatat aaattaatat ttaaaaagta gttaatatta
     3961 ggggagggca tttgcacctc ccttgtaata tgtggaaaat tgaatattag aagaaggagg
     4021 agacttgatg gaaaatcaac aattattagg aacagaacga attagtaaat tactactaaa
     4081 atattctata ccagctataa taggtatgtt ggtaaatagt ttatataatg tagtagatag
     4141 aatttttatt ggaaatatac caggggttgg accacttgca ataacaggtc ttggtgtaac
     4201 aatgccaata atgacaataa tacttgcatt tgggatgttg ataggtatag gaactactac
     4261 taccatatca ataaaacttg ggcaaggtaa agtagaagag gcaagaaaac ttataggaaa
     4321 tgcaatgacg ttatctgtaa taacaggaat tatcataatg atacttggaa tattatttgc
     4381 aaataaaata cttacattgt ttggagcaag tgaaaatact ttaatatatg caaaatcata
     4441 tatcaatatt atattattag gtacagtagt aaatcttctt tccttttctt taaaccactc
     4501 aataagagct gatggtagtc ctaaaatttc agcaggaata atgatagtag gatgtttaac
     4561 taatatagtt ttagactgga tattaatatt tggattcaat ttgggaatac aaggagctgc
     4621 aattgctaca gtaacttctc aggctcttac agctatttta actatagggt attatataag
     4681 tggaaaatca aacttacgat tcagtaaatc taatctaaaa ttagataaaa agctaataaa
     4741 agcagtgttt gcaataggta tgtcgccatt tgctatgcaa cttgcagcaa gtttagttca
     4801 agtaatatca aatattgcac ttaaaactca tggtggagat ttagctatag gggctatggc
     4861 tactatttct tctattgcaa tggtattttt gatgcctatc tttggaataa atcaaggagc
     4921 gcaacctatt ataggtttca attatggagc tgaaaaatat gatagggtta aaaaagcata
     4981 tttaggttca ttagtagtag ctactataat tttatgtatg ggtatggtag tagttatgct
     5041 tttcccagaa gctattatag gtatatttaa taaagaccct gaacttatga atatatctgt
     5101 taatggatta agaatatact tacttatgtt gccaattgta ggcttatcag ttacaggaac
     5161 aaactttata caatctatag gaaaagcaaa aatggctatg ttattgagcc ttttaagaca
     5221 agtaatttta ttgataccag cagtattaat tcttcctaca ttcttaggtt tacagggtgt
     5281 atggacagct caaccagtgt ctgattttat agctacagta attacaggta tagttgtatt
     5341 tagagaatta aaaagatata ctcctaaaac tgaaaaatta aatgaaaatg aaagactaaa
     5401 cgagataact actgagtaaa aatataaatt cagataattg agcaagaaat tgcaaaaaat
     5461 acgattatat gataaaataa aaccgctgtc aaggataaga gaaattctaa ttatggagtg
     5521 attttatgga atttacaaag aaaagcaaat taaaaaatat gtatgtaaac atgaatgtag
     5581 ctagaatgtt gtctaagata aatgagtata agggtagaca actgctttac aaaaaacaac
     5641 caaaagaaat tttagaaaac ttagaaaaaa aatctttagt agattgttct gaatctacat
     5701 acattggaaa tcaaagagat agtagtaatt ttaatctaga aaagttgata agtaatgaag
     5761 ttacacctag aagtagagag gaattgagta ttgttgaata cagagatgtg gtaaaaacta
     5821 ttaacagtgc ttatgagagt attcccatca gttcacaaac gattcttgag cttcatggat
     5881 acttatataa attttcatct actagaggag gaagttataa gtcagataat gattttattg
     5941 aacacaattt aaaacctagc gaatttataa gtattgattc aagtgtcaat aaagttgaaa
     6001 aagctgtaga agaaatatgt gaagcttata atacattgat agaggaagat gaaattgata
     6061 tattaatatt aatttctgca tttgtgttag atttcatatt gatacatcca ttcaaagaag
     6121 gtaatataaa aatggcgaga gtacttatcc tattgttact aaataaaaat gggtatgaag
     6181 ttggaagata tataagttta ggaaagatat ttgatgatag ttcatatgaa tattatagta
     6241 atttaaatta tttgaaagcc tcaataggta gtgaaaaagc agatatgaat gcatggattg
     6301 agtatttttt agagacgata ttaactgcat atgagaagct ggatgatagt ttaaatatat
     6361 ctgataagaa aagacaaaca aaaactagta gaatagagaa aataataaat tctacccttg
     6421 gatattttac aaaagaagat ataagagatt tatgtcctga cattccagaa cctactataa
     6481 atagagtttt taataatcta agaaaacaag ataagataga agttgttgca agaggaagaa
     6541 gtgcaaaatg gaagaaaaaa tattaaaaaa tgtttagata actaaaatgg tatagtgttt
     6601 tacactatac catttttaat gtcattagca tgagcaataa tttaacaact taagcaatat
     6661 caattttatt tattgattat ttttgaactg aaaaatggcg ttatatggta tacctcagtg
     6721 gtaattaatt ttggatgaga agatataata ttacagaata tattaggagt atatgtagaa
     6781 aaaatataat aaaagtgtga ggcttagtaa ttaacaaatt atgtggcttc acactttttt
     6841 ataaaataaa gatacttagc agaagaatat tttagttgat atgtttataa gatggtactt
     6901 gtttgggtaa aagtataaat agtaaaaaag tagaagtaat gtgtataaaa acgtaagtta
     6961 cattctgtaa taatagttat tttataattc aacaaaagaa tagaatgggt atatttgtga
     7021 aataataata taaaataatc ttaggagtga gcttatgaag aaaaaattat tatatataaa
     7081 tgtaaattca aaacctgaag acttatcttc aagtaaaact gtagcaagaa aatttataaa
     7141 taaatttatg gaaaaaaata aagattttga ggttgaagag atagaccttt ataaagaaca
     7201 tataccaaga cttgagtatc agtactttga aaaaagaaat agcatagtta gtgaagaaaa
     7261 tgctaaaaat ttagacgata aggatagaaa agaacttaca aagattagaa atctttgtga
     7321 ccaatttgtg agtgcaagtg tatatgtaat agcagcacct atgtggagtt tatcttttcc
     7381 agcaccactt aaagagtata tagattgtat aattcaagat ggaaaaacta tatcttttga
     7441 aggcaatgat aaaccacaag gaattttaaa tgatattgat agaagtatgg tatatataca
     7501 atcttctggt ggacacatac catgggtgtt gaagccagtt atgaataaag ggttaaatta
     7561 tgtggaaagt attatgaaat ttataggaat taaaaaattt gatgaattgt tagtagatgg
     7621 aactggaact agtgaagaag aaagacaagc tgctatagaa aaagcagctg aaaaaataga
     7681 tggtataata gatgggatga aattttaatt ataatatttt attaaaaata taaaggaaaa
     7741 acctctttta atgtagaaac ttatattgaa ggaggcgaga atcatgcgag aagaaaaaag
     7801 taatgaaaag tatgattgtt attggtgtaa tcaagagaat aatttctgtg tagaaataaa
     7861 agataatata gtcatgatag atgatggcac tggtacgtta aaacaagccg ttttcatagg
     7921 gtataaacaa atccaaatta atttaaactg ttcacattgt caaaacttga atagaataaa
     7981 attaaatttg tagaatttta aaatggaaat tattgaagga attaaaaata gaaagtgtta
     8041 atatttagac tgaaaattat attttataca ataaaagttt atttaaataa cattgtattt
     8101 taatatttat tttcagtctt actttattaa aattattttt tggttatgtc tggaaaatat
     8161 ctgtctacta atttttctga aatatttttt aattggtcag ccattgaagt cagacttaat
     8221 aaggctatca ataaatcatc tttattttct ggatttatac taatattttc aaaattagac
     8281 tctataaagt ccggtatatt ctttctttga ttttctttta ttaacatgaa tttttcgtaa
     8341 catgaaacta aatctttttc actgaaatta tccttttcat acacaccatg taagattctt
     8401 ttaatttctt gtattgtaag tgtatttttc atagaataaa taattatcat ctgtaaaatt
     8461 tgttctttag tatacttttt tcccttaact ggtttgatta atccctcttt gctgtaatta
     8521 tttatcatgg ttttagtaag aattttatca ctttcaaatc ttttattggc agaaagctta
     8581 ttgtcaatta gagaaataat ttgatccata tataagtcaa tagatggaat atcgtttgaa
     8641 gttatatctg cattatttag tgtttctagt attatagtat taagttcatt attcatcata
     8701 tgttacctcc ataatatata taatacacta aattagaaag taaaacaata ttaaggcttg
     8761 taaaaaaaac ataaagtggt ataattaaat atataatata gtaatggaaa ctatatttgt
     8821 gaatctgatt tttaaaatac ataattgtag gaggacgaaa tgtatcaatt ttttttaaag
     8881 ggtagagacc caataagcag tttaactcat tttataggtg cttgtttatc tcttttagca
     8941 actataattt tagtttttca atctgttaca ttacaggaaa cttctctctt gatgatagta
     9001 tctgtatcgg tatttggatt ttcactaatt gctttatata gcgcaagttc gtattatcat
     9061 tttttaaagg ggacaccaga acaagaattg ttttttagaa aagtagacca tgcaatgatt
     9121 tacgtattga ttgctggctc ttatacacca atatgtctga attttatgga aaaaaaagaa
     9181 ggcataatat ttgttacagc aatatggata gttgcattta ttggtataat aataaaaata
     9241 ttttggatgg atgcacctag atggttatct accagtatat atttacttat ggggtgggca
     9301 attgtttttg atataaatgc attcaattca attcctaagg attgccttag actattaatt
     9361 atggaaggtg tatcttactc tataggtgca attatttata taattaaaaa gcctaatata
     9421 agtcctgagt ttggatttca tgaaatattt catattttta ttatgatagg ttctttattt
     9481 cactttttag cagttttatt gtatgtttta tagttttaaa agatttgatt aattgatact
     9541 aaaattctac aatgaataaa atggaactgc cttatataga ttatatcttc gacaataaga
     9601 cagttcctta ttataaatat taaattctac ttataataaa attttgataa aaatagtcca
     9661 ttcaaaatgc ctattccata attcctttaa tgtacttttc atttacgaca tatagtttga
     9721 atttatgtac tataattata tcctctaaat tctctgaaac actaacaatt ctgacacatt
     9781 tgtttctaat ttctacaggt aaatctaaat catttgttaa attcacatag tcatcatatt
     9841 tatacataaa atcatccctt tacattaaga tatacttatt atactatatt ttaataagtt
     9901 tttttaaatt attacaattt ttcccgaaat ttcatttttt atacataaaa tttccaaatt
     9961 aggtaaagat taaatttttt attgtataaa caaaagttac atataaaata tttt
//
LOCUS       DAEHWM010000119         9699 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.122, whole genome shotgun sequence.
ACCESSION   DAEHWM010000119 DAEHWM010000000
VERSION     DAEHWM010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9699)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9699)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9699
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.122"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            252..1292
                     /locus_tag="KNP36_003294"
     CDS             252..1292
                     /locus_tag="KNP36_003294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0875142.1"
                     /translation="MDKHSDSVMYGGMEVYNIWGTTTVDSIIGESDVMRALKNRICKI
                     GNSDSTVAITGESGTGKELIARAIHLAGNRGNKTFVAINCAAIPEPLLESELFGYTKG
                     AFSGADSKGKIGKFELANGGVVFLDEIGDMPIQLQSKLLRVLQEKKFTRIGSNELIDI
                     DVRIISATNRDLFELVKENKFREDLYYRLNVIPLEVPPLRERGDDIQILINNFIDKYS
                     RKMKKNVYHIEPDVEQMLLKYPWPGNIRELENTIELALNLLEEDGIIHKGIINRKILE
                     YFKLNNINIKLLEESDYEISMEQDILTLEEFERAYIKKVLKFYGNDTKSKKLAAKKLG
                     ISLATLYRKIDV"
     gene            1648..2970
                     /locus_tag="KNP36_003295"
     CDS             1648..2970
                     /locus_tag="KNP36_003295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HBF0875143.1"
                     /translation="MFDIDGRPPILKCLPLSMQHILAMIVGTVTVPIVVGGAVGVSPT
                     QITLLVQYALIIAGISTLIQLYPIGNIGSRLPIIFGVGFTYVPTLVAVGGNYGLASIL
                     GAQLIGGVATVLIGIFIKKIRKFFPNIVAGTVVFTIGLSLYPIAINYMAGGVNSPTYA
                     SMQNWAVAAITLVVVIGLSQFAKGYAKLAAIFLGIIVGYCVSLVLGIINFDPIREATW
                     FAIPKPLEFGMEFDMPVIISVVIVSIINAVQAIGDLSATTMGGMDRNITDKELSSGVI
                     GSGICTMIGALFGGLPPSSYSQNVGMVAMNKVISRFVLGIAGIFMLLSGFVPKFGALM
                     TTIPYSVLGGATISIFSMITMTGIKLIITEELSSRNITIVGLAIALGMGITSVPAAQE
                     AFPSFVKLVFGESPIVIATLVAFVLNLIIPNKSLEDEAKERAVMEETN"
     gene            3267..4628
                     /locus_tag="KNP36_003296"
     CDS             3267..4628
                     /locus_tag="KNP36_003296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine/pyrimidine permease"
                     /protein_id="HBF0875144.1"
                     /translation="MKTRNTSKYDVDGIPPLKESIPLALQHLLAMIVGNMVPAILIAN
                     VVGLNQGQATMLIQGSMLAAGLATFLQLYPIPLFKGFKLGSRLPVMMGMSYVFLGACL
                     SVAAKDGLAALFGAQIAAGVIVFFVGFGVKKIRHIFTPIVSGTIIACMGLGLFATAIK
                     NLAGGEGTQTFGSPINFTVGVIVAFVIIMINKYGKGLVKNSSILIGILVGYAISLVLG
                     LVDFSAVQGAAIVSLPTPAAFGLEFRPELIVMFTIIYIIGIADMMGACTIATVGAMDR
                     EVTDEELASVVLGNSITSIISSLFAALPTGVFSQNTVIVSMNKVTSRFVIALGALVLL
                     LAGISPALGAIMTTIPSCVVGGATLVVFSSIAMSGFSIMSMDGFTEENNLIAGVSIAT
                     SMGLTTAPQVLDQFPETIGTVLGGSSIVSGAIIAILLQTLFKLKSRKSAENVTSNLEE
                     NIG"
     gene            4701..6095
                     /locus_tag="KNP36_003297"
     CDS             4701..6095
                     /locus_tag="KNP36_003297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HBF0875145.1"
                     /translation="MIDILIKNAIIVTVNKDRDVIFDGAIAIQGDRILDIGNTVDIEP
                     KYLDAKKVIDANGKVIFPGFINTHNHLFQVLLKGLGDDMALHEWLNTMMFPSAKFLTE
                     QDTYDAAMLGCMEGLKSGITTMVDYMHTHNRPGLTDGIVKAYKDLGIRGVVGRGCIDL
                     GIHKELIEDVETVEKDLRRVFEKYHNSENGRIKICVAPSSMWAISEEMGKMLWNIVKE
                     YDSYFTVHISETEFARTATKDIHGEIDIKLLEKWGIVGPEVVAVHCVCITDEDMEMLK
                     KYDIKVSHNVASNMYLASGVAPVPEMLKKGINVSLGLDGAASNNAQDMVELMKLTALQ
                     HKVNNCDPLAISAEKVLEMATIEGARTLRMEDEIGSLEIGKKADLVIFNSMLSPKSIP
                     LHNPVSTLVYSASMHNVESVLVDGNVILENGKVTTIESEEQVLLNAQHAAEELCKRAN
                     VTNRMEGHKWNSLY"
     gene            6157..6627
                     /locus_tag="KNP36_003298"
     CDS             6157..6627
                     /locus_tag="KNP36_003298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="HBF0875146.1"
                     /translation="MEKIKLNINDYMYEIEVEKNETLLHVLREKLNLTGAKQGCNSGS
                     CGACKVLIDGVDMKSCKLLAKNCEGKVIYTIESFANGENLHPIQEAFIEVGAVQCGYC
                     TPGMIITTQALLNRNASPNEDEIREAFKENLCRCTGYVKIIEAVKLSAARLGGR"
     gene            6630..8846
                     /locus_tag="KNP36_003299"
     CDS             6630..8846
                     /locus_tag="KNP36_003299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="HBF0875147.1"
                     /translation="MEKVIGKSYPLKDAALKVTGQMKYVADMKPQNVLYAKMLLSPVA
                     HAKIKSIDTSEAEKVVGVRAIATYLNTSQRKYNGSLRFYEHKIPENEVIFSDTVRFVG
                     DRVAAVAAETPEIAEKAVKLIKVEYEELPAVFTIQDAIKEDAICIHGDSNIVSQNNIN
                     GGDVEKGFKECDYIFEDEYSTPAIHHSAIETHSVIAHYDYNDKLTVHTPCQNTFGFRI
                     ILSQIFGMSLNKVRVIRPAIGGSFGGKLELTIEPVAAALSKMTRRPVKMVLTRKESMI
                     STRTRHGSFVKLKTGVNKDGEVIAQDIKIYTNTGAYASSALNVIGALSHKVFKVYKIP
                     NIKFTGMPVYTNTPIAGAMRGYGSPQIFMAQQAQFAKIAKEIGMDLVDFQNKNAVEPD
                     DVDIIFHGSLGNPRVLDCIEQGKKMFKWDEKKKLPKEEGKYLRGIGMAIGAHGNGVFG
                     AHRDVVTLTLKLNEDGTLTLLTGAHDMGNGVVTMQTMMVAEVLGITPDKVDTFETDTD
                     ACTFNLGDYASRGVFVEGGGAKKTAEKLKNLILEEAEKLLETSKEDLYLDNGCVISKL
                     DENVKASLSDVAVYSQSKSLRELTVVEDYSSPAGRTSYGVHFAEVLVDKETKDIKVVD
                     FVAVHDVGRVINPLNLEGQLEGGIHMGLGYALSEELAFDEQGRPKATDFKTYKLFRTV
                     DMPKCQVAFVDGYEKAGPFGGKSIGECAVVPVAPAVANAVYNATDVEIHSLPIKLK"
     gene            8929..9600
                     /locus_tag="KNP36_003300"
     CDS             8929..9600
                     /locus_tag="KNP36_003300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0875148.1"
                     /translation="MAKILGICGSPRKGATEYAVLEALKEAETIPGIETEYWSVRGKK
                     ISPCVHCDACIRKETMCIIKDDIQELEQKILEADGIIVGSPVYDMNITAQLTAVFNRL
                     RPMYLVHPGKLQNKVGAAITTGGTRYGGQELTKLPIINFFLMHEMLVSGGLGGCYIGG
                     TIWSKDGKAKGAQEDETGMDTVKRLGKGAAEAVMVSKFGLEKWNVVKEELDVKKDEKS
                     PLRDH"
BASE COUNT         3635 a         1136 c         1942 g         2986 t
ORIGIN      
        1 agaacttaaa ttaaaaattt taaaaattat ttccatataa aatatggcat tgtaattgct
       61 tatttaatag aggatttttg taaaatgaag aaagtatatc tatcaaatta aaactaagta
      121 gatatacttt ttattaagtt ttgttttaaa ataatattat taaattataa ctaagctttt
      181 ctgttatgat ataattaaat agataatgtg aatgattatt atatagaata cttatttgga
      241 gttgatattt tatggacaaa cacagtgatt cagtaatgta tggtggaatg gaagtatata
      301 atatttgggg aacaacaaca gtagactcca taattggaga gtctgatgta atgcgtgctc
      361 ttaagaatag aatttgtaaa attggaaata gtgattctac tgtagctata actggagaaa
      421 gtggcactgg aaaagaatta atagcaagag ccattcatct cgcaggaaac agagggaata
      481 aaacattcgt tgctataaac tgtgctgcta taccagaacc tttactagaa agtgaacttt
      541 ttggatatac aaaaggagct tttagtggag cagattcaaa aggtaaaatt ggtaagtttg
      601 aattggccaa tggaggggtt gtatttttag atgagatagg agatatgcca attcaactac
      661 aatcaaagtt attgagggta ttacaggaaa agaagtttac gagaataggt tcaaatgaac
      721 taattgatat agatgttaga atcatatcag ctactaatag agatttattt gagttggtta
      781 aggaaaataa atttagagaa gacttatact atagattgaa tgtaatacct ttagaagtgc
      841 ctccacttag agaaagagga gacgatatac aaatattaat aaacaatttt atagacaaat
      901 attcgagaaa gatgaagaaa aacgtgtacc atatagagcc agatgtggaa caaatgttgc
      961 ttaagtatcc ttggccagga aatattagag agttggaaaa tactatagaa ctggcattaa
     1021 accttcttga ggaagatgga ataatacata aaggaataat aaatagaaag atacttgaat
     1081 attttaagtt aaataatata aatataaagt tacttgagga aagtgactat gagataagta
     1141 tggaacaaga catacttaca cttgaagagt ttgaaagagc ctatataaag aaagtgttaa
     1201 agttttacgg aaatgatact aagtctaaaa aactagctgc caaaaaactt ggaatatcac
     1261 tagctacatt gtacagaaaa atagatgtat aataattagg ctttttattc tcaattctaa
     1321 aatttgaaat tataaaattg ataaaaaaca cttggaaaac tattttctaa gtgttttttt
     1381 gtgtaatagc attttattat ccaaaaataa aaaaaattta aaagaattta aaaaaataaa
     1441 tgctttaata aattatcaaa tactaacaaa tataataaaa attatatatg taaaacaatt
     1501 atgttaaaaa attggcatta taattgcttc atattaagtt gagatgacaa aataaaaaaa
     1561 gaaaggatgt tgtgtgagat aataataact gtcattaaaa aatagttggg agtgataacc
     1621 ttgagtaaat atcaaaagaa tgtttctatg tttgatattg atggaaggcc accaatttta
     1681 aagtgtttgc cactatcaat gcaacatata ctagcaatga tagttggaac tgttacagta
     1741 cctatagtcg taggaggagc tgtgggtgtt agccctacac aaataacact tttagtgcaa
     1801 tatgcattaa taatagctgg tatatcaaca cttatacaac tatatccaat aggaaatatt
     1861 ggttcaagat tgcctataat ttttggagtt ggttttactt atgtaccaac acttgtagca
     1921 gtcggaggaa attatggatt agcaagcatt ttgggtgcac aattaatagg gggagtggct
     1981 acagtattaa tagggatatt cataaaaaag ataagaaaat tttttccgaa tatagttgca
     2041 ggaacagtgg tttttacaat tggattatct ttgtatccta tagcaataaa ttatatggca
     2101 ggtggtgtaa atagtcctac ttatgcctct atgcaaaact gggcagtagc ggctataaca
     2161 ttagtggtag ttataggtct tagtcaattt gcaaaaggat atgcaaaatt ggcagcaata
     2221 tttttgggaa ttatagttgg atattgtgta tctttagttc tgggtataat aaattttgac
     2281 cctattagag aggcaacttg gtttgcgata cctaaaccgc ttgaatttgg gatggaattt
     2341 gatatgcctg taataatctc agtagtaatt gtaagtataa tcaatgctgt tcaagcaatt
     2401 ggagatttat cagctactac aatgggaggc atggatagga atatcacaga taaggaatta
     2461 tcaagtggag taataggaag tggaatttgt actatgatag gagctttgtt tggaggttta
     2521 ccaccatcat catatagcca aaacgtgggg atggtagcta tgaacaaagt aataagtaga
     2581 tttgtgcttg gaatagctgg tatatttatg ttattgtcgg ggtttgtgcc taaatttggt
     2641 gcactaatga ctactatacc atattctgtt ttaggaggag ctacaatatc tatatttagt
     2701 atgataacaa tgacaggtat aaagttaatt attacagaag agttgtcatc aagaaatatt
     2761 accattgttg gtttggcaat tgccttaggc atgggaataa catcagtacc agcagcccaa
     2821 gaggcatttc cttcatttgt aaagttagta tttggagaat ctccaatagt aattgcaaca
     2881 ttggttgcat tcgttttaaa tctaataata ccaaataaaa gtctagagga tgaggctaaa
     2941 gaaagagctg ttatggaaga gactaattaa gatataataa tttaaaagaa ttgtttaaat
     3001 tatttagtat gagattgtta gattattttt gatagctatt cattttaata aaaaatttaa
     3061 caaataaata tataccaggc aattaatgtt catttaagtt gaaaatcggg gagggaatat
     3121 ttagaaattt gttaattttt tataaaaata gctcagttta gctgtgttta tcggttgagc
     3181 aataaattca tggtcataaa aatatttata gaaaataatt ataaaaatat ttagtcaaga
     3241 tatttatgta tgggaggatt tattttatga aaacacgtaa tacttcaaaa tatgatgtcg
     3301 atgggatacc accactaaag gaatcaatac ctttggcctt acaacatctg ttagcaatga
     3361 tagtaggaaa tatggtacct gcgatattaa tagcaaacgt ggtaggactt aaccaggggc
     3421 aagcaacaat gttgattcag ggttctatgt tagcagcagg tttagcaacg tttttacagt
     3481 tatatccaat acctttattt aaaggattta agttaggttc aagattacct gtaatgatgg
     3541 gaatgagtta tgtattttta ggagcttgtc tttcagtagc agctaaagat ggtttagcag
     3601 ctctatttgg agcacagatt gctgctgggg taatcgtatt ctttgtagga tttggagtta
     3661 agaaaattag acatatattc actccaatag tttctggaac tataatagca tgtatgggac
     3721 ttggactatt cgcaacagct ataaagaatt tagctggagg agaaggcaca caaacatttg
     3781 gaagcccaat aaacttcaca gtaggagtta tagttgcttt tgtaataata atgataaata
     3841 aatacggtaa aggtttagta aaaaattctt caatattaat aggaatatta gtaggttatg
     3901 ctatatcttt agttttagga ttggttgatt tctcagccgt tcaaggagca gctatagtat
     3961 ctttaccaac accagcagct tttggattag aatttagacc agagttaata gtaatgttta
     4021 ctattattta cataataggt atagctgata tgatgggtgc ctgtacaata gctacagtag
     4081 gagcaatgga tagagaggta actgacgaag aattagcatc agttgtttta ggaaattcta
     4141 taacttctat aatttcatca ctatttgcag ctcttccaac tggagtattt agccaaaata
     4201 cagtaattgt atctatgaac aaagttacaa gtagatttgt aatagcacta ggggcacttg
     4261 tattattact agcagggata tctccagcat tgggtgcaat aatgacaact ataccatctt
     4321 gtgttgttgg tggagcaact ttagtagttt tctcatcaat agcaatgtct ggtttctcta
     4381 ttatgagtat ggatggattc actgaagaaa acaatcttat agcaggtgta tctatagcaa
     4441 caagtatggg tcttacaact gctccacaag ttttagacca attcccagaa acaattggaa
     4501 ctgtccttgg agggtcaagt atagtttctg gagcaataat agctatatta cttcaaacat
     4561 tatttaaatt aaagtcacgt aaaagtgctg aaaacgttac ttcaaatctt gaggaaaata
     4621 ttggataaat gtattagata taatatgaga aaaccatatg gtaaaatgtt gtaatgaaag
     4681 tattcaaagg gggatttaag atgattgata tactaataaa aaatgcaata attgttacag
     4741 ttaataaaga cagagatgtt atatttgatg gagcaatagc tattcaaggt gacagaatct
     4801 tggacatagg aaatacagtt gatattgagc ctaagtatct tgatgctaaa aaagttatag
     4861 atgctaatgg aaaagtaata ttccctggct ttataaatac tcataatcac ctgttccaag
     4921 tgttattaaa aggtttaggt gatgatatgg cacttcatga gtggttaaat acaatgatgt
     4981 ttccatcagc aaaattctta acagaacaag atacttatga tgctgcaatg cttggatgta
     5041 tggaaggttt aaaaagtggt ataactacaa tggttgatta tatgcatact cacaatagac
     5101 caggacttac agatggaata gtaaaggcat ataaagattt aggtataaga ggggttgtag
     5161 gtagaggttg tatagattta ggtattcaca aagagcttat agaagatgtg gaaacggttg
     5221 aaaaagattt gagaagggta ttcgaaaaat atcataattc agaaaatgga agaataaaaa
     5281 tctgtgtagc tccttcttca atgtgggcta tatctgaaga aatgggtaag atgctttgga
     5341 atatagttaa agaatatgat tcatatttta cagttcatat atctgaaaca gaatttgcaa
     5401 gaacagcaac aaaggatata catggagaaa tagatataaa attacttgaa aaatggggta
     5461 tagtaggtcc agaagttgta gcagtacatt gtgtatgtat aactgatgaa gacatggaaa
     5521 tgcttaaaaa gtatgacata aaagtttctc ataatgtagc aagtaacatg tatcttgctt
     5581 ctggtgttgc acctgtgcca gaaatgttaa aaaaaggtat aaatgtgagt ttaggtcttg
     5641 acggtgcagc aagtaataac gcacaagata tggtagagct tatgaaatta acagctttac
     5701 aacacaaagt aaataattgt gaccctctgg caatttctgc agagaaagtt cttgaaatgg
     5761 ctacaattga gggagcaaga actcttagaa tggaagatga aataggttct ttggagattg
     5821 ggaaaaaagc tgacctagta atatttaact caatgctttc tccaaaatca atacctcttc
     5881 acaatcctgt atcaactttg gtatactcag ctagtatgca caatgtagag agtgttttag
     5941 ttgatggaaa tgtaatactt gaaaatggaa aagtaactac aattgaaagt gaagaacaag
     6001 tgttgcttaa tgcacaacat gcagcagaag aattatgtaa gagagctaat gtaactaata
     6061 gaatggaagg acataagtgg aatagcttat actaatatta aaataagatt gtaataatat
     6121 tctattacaa cattagttta tctgtaggag gagaaaatgg aaaaaataaa attaaatatt
     6181 aatgattaca tgtatgaaat agaagttgaa aagaatgaaa ctcttttgca tgtacttcgt
     6241 gaaaaattaa atctaactgg agcgaaacaa ggttgtaata gtggcagttg tggagcatgt
     6301 aaagttttga tagatggagt tgacatgaaa tcttgtaaac ttcttgcaaa aaactgcgaa
     6361 ggtaaagtta tatacactat agaaagtttt gctaatggag aaaatcttca tccaatacaa
     6421 gaagctttta tagaagtcgg agctgtacaa tgtggatatt gtactcctgg tatgattata
     6481 acaacacaag ctcttttaaa tagaaatgca tctcctaatg aagatgaaat tagagaagct
     6541 tttaaagaaa atctctgtag atgcacagga tatgtaaaga ttatagaagc tgtaaaatta
     6601 tctgcagcta gattaggggg tagataatta tggaaaaggt aataggaaaa tcataccctc
     6661 taaaagatgc agctttaaaa gttactggtc aaatgaaata cgtggctgat atgaaaccac
     6721 aaaatgtact ttacgctaag atgcttttaa gccctgtagc acatgcaaaa ataaaaagta
     6781 tagatacaag tgaagctgag aaagtagtag gtgttagagc tatagctact tatctcaata
     6841 catcacaaag aaaatacaat ggttcattaa gattttatga gcacaaaata cctgaaaatg
     6901 aagttatatt ttcagataca gttagatttg ttggtgaccg tgttgcagca gtagctgcag
     6961 agactccaga aatagcagag aaagctgtaa aacttataaa agttgaatat gaagaattgc
     7021 cagctgtatt tactatacaa gatgcaataa aagaagatgc tatctgcata catggagatt
     7081 caaatatagt ttctcaaaac aacataaatg ggggagatgt agaaaaaggc ttcaaggaat
     7141 gtgattatat atttgaagat gaatactcta ctccagcaat acatcatagt gcaatagaga
     7201 ctcatagtgt aattgcacac tatgattata atgataaatt aactgtacat acaccttgcc
     7261 aaaatacatt tggatttaga ataatactat ctcaaatttt tgggatgtca ttaaataaag
     7321 taagagttat aagacctgct attggaggct catttggtgg aaaattagaa cttacaattg
     7381 aaccagtagc agccgcatta tcaaaaatga caagaagacc agttaaaatg gttcttacaa
     7441 gaaaggaatc tatgatatca acaagaactc gtcatgggtc ttttgtaaaa ttaaaaactg
     7501 gtgtaaataa agatggtgaa gtaatagcac aagacataaa aatatataca aatacaggag
     7561 catatgcatc aagtgcttta aatgttatag gagcacttag tcataaagta tttaaagttt
     7621 ataaaatacc aaatataaag tttactggga tgcctgtata tacaaataca ccaatagcag
     7681 gagctatgag aggctatggg tcacctcaaa tatttatggc tcaacaagct caatttgcga
     7741 aaatagcaaa ggaaataggt atggatttag tcgattttca aaataaaaat gcagtagagc
     7801 cagatgatgt cgatataatc ttccacggtt ctcttggaaa tcctagagta ttggattgta
     7861 tagagcaagg taagaagatg tttaagtggg atgaaaagaa aaaacttcca aaagaagaag
     7921 gaaaatattt aagaggtata ggtatggcaa taggtgcaca tggtaatgga gtttttggtg
     7981 cacatagaga tgttgttaca ttgactctta aattaaatga agatggtacg ttgacactac
     8041 taacaggagc tcatgatatg ggtaatggtg ttgtaactat gcaaacaatg atggtagctg
     8101 aagttttagg aataacacct gataaagttg atacatttga aactgatacg gatgcatgta
     8161 cattcaacct tggtgactat gcaagtagag gggtatttgt agaaggtgga ggagctaaaa
     8221 agacagcaga gaaattgaaa aatcttatat tagaagaagc agaaaaatta cttgaaacat
     8281 caaaagaaga tttatatcta gacaatggat gtgtaattag taaacttgat gaaaatgtaa
     8341 aagcatcact ttctgatgtc gcagtatata gtcaaagtaa atcattaaga gagttaactg
     8401 ttgttgaaga ttattcttca ccagctggac gtacttctta tggtgtacat tttgctgaag
     8461 ttttagtaga taaagaaact aaggatataa aagtagttga ttttgtagct gtacatgatg
     8521 ttggtagagt tataaatcct ctaaatttag aaggacaatt agaaggtggg attcatatgg
     8581 gtctaggata cgcattgagt gaagaattgg catttgatga acaaggtaga cctaaagcta
     8641 ctgattttaa aacatataaa ttatttagaa ctgtagatat gccaaaatgt caagttgcat
     8701 ttgtagatgg ttatgaaaaa gctgggcctt ttggtggtaa gagtattgga gaatgtgccg
     8761 ttgtaccagt tgcgccagct gttgcaaatg cagtatataa tgcaactgat gtagagatac
     8821 attcattacc aataaaatta aaatagtaga aattaaagca gaaataacaa tttattgtat
     8881 ttgtaaatag ataataaaaa tagatttatt tggtgaggag atattattat ggcaaagata
     8941 ttaggtattt gtggaagtcc acgtaaagga gcaacagaat atgcagtgtt agaagctttg
     9001 aaagaagcag aaactatacc tggtatagaa actgagtatt ggtcagttag agggaaaaaa
     9061 ataagtcctt gtgtacattg tgatgcatgt ataagaaaag aaactatgtg tattataaaa
     9121 gatgatatcc aagaattaga gcaaaaaata ttggaggcag atggaattat agtaggttct
     9181 ccagtttatg atatgaatat aactgctcaa cttacagcag tatttaatag acttcgtcca
     9241 atgtatttag ttcatccagg aaaacttcaa aataaggttg gtgcagctat aactactggt
     9301 ggaactagat atggtggcca agaattgaca aaacttccta taataaattt cttcctaatg
     9361 catgaaatgt tagtgtctgg aggtttaggt ggatgctata taggtggtac aatatggagt
     9421 aaagatggaa aagcaaaagg tgcccaagag gatgagacag gtatggacac agtaaaaaga
     9481 cttggaaaag gtgcagcaga ggcagttatg gtttctaagt ttggtcttga aaaatggaat
     9541 gtcgtaaaag aagaattaga tgttaaaaaa gatgaaaaat cacctcttag agaccactaa
     9601 agatttatta tattattgaa tatatacaaa tagtgatgta atagattatt gcatcactat
     9661 tttatgtttt aatttagatt ttataaattt tatattaaa
//
LOCUS       DAEHWM010000120         9593 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.123, whole genome shotgun sequence.
ACCESSION   DAEHWM010000120 DAEHWM010000000
VERSION     DAEHWM010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9593)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9593)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9593
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.123"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..252)
                     /locus_tag="KNP36_003301"
     CDS             complement(<1..252)
                     /locus_tag="KNP36_003301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875149.1"
                     /translation="MDFGNINLILIGIIVIIGTTIIYLIKPKTAFCSKKYFNKLESIY
                     GNIDKKKTVKLEVLYRYVTGLEYIAIGLFTRRLDITIIAI"
     gene            complement(535..831)
                     /locus_tag="KNP36_003302"
     CDS             complement(535..831)
                     /locus_tag="KNP36_003302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875150.1"
                     /translation="MYFKTYILKREVNNKQLEITRSFDLDNLICTATEILKDNEIDLI
                     ITDEVNNVVWRNEKSTPPARECLVIAIEVYWWYTSIFLLYHINYVIKKNYLNRF"
     gene            complement(850..1263)
                     /locus_tag="KNP36_003303"
     CDS             complement(850..1263)
                     /locus_tag="KNP36_003303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875151.1"
                     /translation="MKVKSKRSFIVGIIVCVLCCASLVIYCILKDKRFLISSFLLIVI
                     AIFNFCNAFSRKGIVEELHDSTDERDLYLTMKTSHILVKIMNYTLFTFTFLFIIAYSA
                     WKNQSLLVIAITLCVIEIFLFVAYLLINIFLEKKE"
     gene            complement(1247..1480)
                     /locus_tag="KNP36_003304"
     CDS             complement(1247..1480)
                     /locus_tag="KNP36_003304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875152.1"
                     /translation="MKTKVREFRTNMGLTQQQLADLVHVSNRTIISIEKEQYSPSLML
                     AYRMAQVFGTTIEELCCLKENKEMEDKKHESKE"
     gene            1699..2073
                     /locus_tag="KNP36_003305"
     CDS             1699..2073
                     /locus_tag="KNP36_003305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875153.1"
                     /translation="MKISKLPEAELKVMRYICEANKVLTSRELVAAMEEKYEWNESTT
                     FTVLKRLERREFLSTEKIGKLTHYNILVKEKKYLRFETKEFLKNIHKNSISSLMSALH
                     GEDDEVDEDKLSELEECFKNLK"
     gene            2685..3377
                     /locus_tag="KNP36_003306"
     CDS             2685..3377
                     /locus_tag="KNP36_003306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875154.1"
                     /translation="MYNILVVDDDKEIVDSIEIYLKSEGFKIYKAYDGMKALEIITEN
                     DIHLILMDIMMPKLDGIKATVKIREERNIPIILISAKSEDTDKIIGLNIGADDYITKP
                     FNLLELIARVKSNLRRYVTLGNYEDTCKEILKSGALELNTLTKEVKIDGENIKMTPIE
                     YKIIELLLENKGRVFSIDEIYEKVWNEESFNSENTVAVHIRRIREKIEINPKEPRFLK
                     VVWGVGYKIEKF"
     gene            3573..5633
                     /locus_tag="KNP36_003307"
     CDS             3573..5633
                     /locus_tag="KNP36_003307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0875155.1"
                     /translation="MEKYRVLKLVSLIIISISFPLTILLVTIGLAEPKYNIQKTSTKS
                     GIFDISDDFYDSNIFDEGTMASLLPKFKLSVGGKLTSKEKGKFQQEGKSIDLSSSDSE
                     YDKIMINEQASEEYLSYLKNIKVYVINTYTGVFYTNTSYASLYDFKQKTKSYCNVEII
                     NKIGKSSYIKTINGEKFELNNLSLELNEVDEGFEAYVSFPEEPTIEDGIVYTNFQIFK
                     QATEKVRLFFVASLSLAIICLLSIILYIKIKGEVLKRNNVFLLIYSKIPMEFNVILVS
                     ISIAILTIYALAVSYHIDVIALVSLSLLIVSNNIFFINVQLSYLENKMCIFKTSIIVR
                     VILWLIKTVREVSNAIKKVSLARKVIVIVIISLALIMAISTRSIGMGLLFSICIFLGF
                     TIYITKRLSYLSYVIEGTERIKKGELDYKIKITGNDNFTSLAENINNIGEGLDRAIEE
                     QVKSERMKSDLITNVSHDLKTPLTSIINYVDLIKKEESIQPEYINDYINVLESKSKRL
                     KLLIEDLFEASRVSSGNIELQISKIDLVQLLRQSIGELEEKLSKNNLYLKLNVPNDKV
                     YIWADGRRMYRVFENLLSNIAKYSLEETRVYIDVYDYGENVKVTMKNISSYELNFDPS
                     EIMERFKRADESRNTEGSGLGLAIARDLVALQGGKFYIEIDGDLFKANLEFQKYEEEI
                     TNME"
     gene            complement(5838..6161)
                     /locus_tag="KNP36_003308"
     CDS             complement(5838..6161)
                     /locus_tag="KNP36_003308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HBF0875156.1"
                     /translation="MNNNYIFFIIIGMYIVTYLPRVLPMLIFSKKEMPDFLKKIMKFI
                     PVAILTSLTAKDVFFNGDSLYLSIANPKIISFMIVLLVAYKFKSIGISIITGVISIYL
                     FGIIL"
     gene            complement(6154..6855)
                     /locus_tag="KNP36_003309"
     CDS             complement(6154..6855)
                     /locus_tag="KNP36_003309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HBF0875157.1"
                     /translation="MERTQQLKESFIASIPIFLGYIPIGIVGGILLQKSGLSPFQIAL
                     MVTLVFGGSSQFIAASMISTGASVTSIVLTTFIVNLRHFLMSSNLNMYIKNKSPKFIL
                     PFCHTITDETFAVNYEKFTAGNWSDRNAIYLNFFCLISSVLANFIGAFLGESISIDSS
                     ISGFILTSMFIALIVSQIKNKIYIVVFISSIIISVILYALFKSNLVIIVASILASLIG
                     FFIEESYCKKEESYE"
     gene            complement(7133..8518)
                     /locus_tag="KNP36_003310"
     CDS             complement(7133..8518)
                     /locus_tag="KNP36_003310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0875158.1"
                     /translation="MPINSFENYPMNWKRKRPSKGQILYKALAEQLEQDINNGFLLPG
                     TKLPPQRELADFLDVNVSTISRAFKICEKKGLISGVTGSGTFVSYDTRSNLFLMSSNN
                     KITFIEMGTMNPDFTLEEMNTLFKHIIKEIDFKTIFQYGQRDGAKWQKEAIAKLIYKA
                     GLETTSDSLLPASGGQNAIVAILAGLFQHGDRIGVDPLTYPGIKTAAKMLGIQLIPIK
                     QEDNEISEEGLLYACKNENIKGLYIIPDYQNPTTHIMSQNGRKMIANIASKYNLIVIE
                     DAIHSLLNETHLNPVASYLPNQTIYITSLSKIIAPSLRLAYISTPKQYREALSSALYN
                     INLSQSYFLTEIAYRMITSGEADKLINARRKSARRRNKIINQYLSGYNLLGNEECIFR
                     WLILPDGIMAEKFEIQALKEGVQVYASERFAVGKEKPISAIRIAVCATESTEELKAGL
                     SVLKRLLEEKK"
     gene            complement(8626..>9593)
                     /locus_tag="KNP36_003311"
     CDS             complement(8626..>9593)
                     /locus_tag="KNP36_003311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBF0875159.1"
                     /translation="ILGIIAISFYYLRTNFKFYNYIENFKKEILEIDITSILDEQAKE
                     LSINKKLQIYKVKGIYSPAIIGLTRCKIIIPEKKYNNKELRFIFKHELIHYKRKDNLF
                     KLLISIICIIYWFNPILYLLKKYFHELCELSCDEIVIDKCTTSEIKEYAYIILDTIKY
                     QKSLKYSSFVSQFLNKKNIILKKRLDSMFNQDKKKINLGLKFLLTFIIIGSIFSINSN
                     FKQNEDVEYTIGKINYNKNGETYGTHIIDSNGNSIEPELIQTIGRGKKVGYVKKRDLY
                     DCDNQPKTPEEAVLYTRKRNFNIFKKTIPLYDKEGIKIIGRFEIN"
BASE COUNT         3689 a         1139 c         1319 g         3446 t
ORIGIN      
        1 tattgctatt attgtaatat ctaatcttct tgtaaataag cctattgcta tatactcaag
       61 acctgttaca tagcgataaa gtacttctag tttaacagtt tttttcttat ctatatttcc
      121 atatattgat tctaatttat taaaatattt tttactacaa aaagcagttt taggtttaat
      181 taaatatatt attgtagttc ctattataac tattattcca ataagtataa gattgatatt
      241 tccaaaatcc atagcagata cctcctatta aatttgcttt tcttaatcaa agtatatcag
      301 taacacaagt acaaagagta tctaaaatat tacaaatatt aacaggatag ataaaactat
      361 agtaaaaatt gtaataataa agcgaacgaa aattatcata ctaaaacata agacatgtta
      421 taattgtatt agatagaaga ttaacataca ccaaagcact ccttataata aagagtgctt
      481 atttttttga aattcatcaa tatataaact atcaagaacc ttattcaaca caccttaaaa
      541 tcgatttaaa tagttctttt tgataacata atttatatga tataataaaa aaatagaagt
      601 gtaccaccaa tacacttcta tagctataac taagcattct cttgctgggg gagtgctttt
      661 ttcatttctc caaacaacat tatttacttc atcagtaatt atcaaatcaa tctcattatc
      721 tttcaaaatc tctgttgcag tacaaattag attatctaag tcaaaacttc gagttatctc
      781 tagttgtttg ttatttactt ctctttttag tatataagtt ttaaaataca tttatatcac
      841 cccttgtatt tactcttttt tctctaaaaa tatattgata agtaaatatg caacaaataa
      901 aaaaatctca atgacacata gtgttatagc tataactaga agtgattgat ttttccatgc
      961 actataagct atgatgaaaa gaaatgtaaa agtaaataat gtataattca taattttaac
     1021 taagatatga cttgttttca ttgttaagta caagtctctt tcatctgtac tatcgtgtaa
     1081 ttcttcaaca atgccttttc ttgaaaaagc attacaaaaa ttaaagattg ctattacaat
     1141 taaaagaaat gatgaaatta ggaatctttt atcttttaaa atgcaataaa taactaaact
     1201 agcacaacat aacacacaaa ctataatacc cactataaaa cttcgtttac tctttacttt
     1261 catgtttttt atcctccatt tctttatttt cttttaaaca acatagttct tcaatcgttg
     1321 taccaaacac ttgtgccata cgataggcaa gcataagaga agggctatat tgctcttttt
     1381 caatagaaat aattgttctg tttgatacat ggactaaatc agcgagttgt tgctgtgtta
     1441 gacccatatt tgttcgaaat tctcgtactt ttgttttcat tccataacct ctttctatat
     1501 gaagctaact tcatgtgaag ttaacttcat aatatcctaa aatgagtaaa atgtcaatct
     1561 cattagataa gtattataaa acctaaaaga ataatatggt aaaaattgga tggaattatt
     1621 taccttaatt ctcttgtttg taaaacttta ttgatataga atttaacata tacataaatc
     1681 ggcaaagggg cgcgaattat gaaaattagt aaattaccag aagcggaatt aaaagttatg
     1741 agatatattt gtgaagctaa caaggtatta acttctaggg aattagttgc tgcaatggaa
     1801 gaaaaatatg agtggaatga atcaactaca tttacagttt tgaaaagatt agagcgaaga
     1861 gagtttttaa gtacagagaa aataggcaaa cttacacatt ataatatact agtaaaagag
     1921 aaaaaatatc taaggtttga aacaaaggaa tttttgaaga acatacataa aaattcaatt
     1981 tcaagtttaa tgtcagcgtt acatggtgaa gacgacgaag tggatgaaga taaattaagt
     2041 gaactcgaag aatgttttaa gaatttgaaa taagaaaatg acaaattgat acataataaa
     2101 taaaatgaag gtatgaaatt ataacttttt ctaccttcat tttgtttatt attctgaaca
     2161 tgttaagaaa atgaaataag tttgtatttt agttatataa attttaatag aatatgtaca
     2221 gtatatagta gatagaatgt ataaaaatag aatttaaata agtagctatt attgcagtga
     2281 aatgaatgtt tctaagtata tttgggtgga agaatggtgg aagaaaatta gtgaaatgta
     2341 attcttccac cattcttcca cctagaaaat agaaactgtt taataagaat taatatacat
     2401 taattcagct gaatgcaatc aaaatactta aatgaaagta atctgaaaac aacataattc
     2461 aaatcaattt attcaaataa acctcaattt atcttaaatc ttaagaaata tttaagaatt
     2521 aggataatat tttcttaaga tttatatttt attatatagt tataagggaa agttacaaaa
     2581 atgtaagcca aagtaatata acaatttagt cattgttgag aaagggagtg aaagatattg
     2641 tataatatag ataagtatta ttatacaata gaggaagtga aaatatgtac aatatattag
     2701 tagtagacga tgataaagaa attgttgatt cgatagaaat atatcttaaa tcagaaggat
     2761 ttaaaatata taaagcatat gatggaatga aagctttgga aataataaca gagaatgaca
     2821 ttcatctaat actaatggat ataatgatgc ctaaattaga tggaatcaaa gcaactgtaa
     2881 aaatacgaga agaaagaaat attccaataa ttttaatttc agcaaaaagt gaagatacag
     2941 ataaaataat aggattaaat attggagctg atgattatat aacaaagcca tttaatctat
     3001 tagagcttat agctagggtt aaatcaaact taagacgata tgtaacttta ggtaattatg
     3061 aagatacatg taaagaaatt ctaaaaagtg gagctttgga gttaaataca ctaacaaaag
     3121 aagttaaaat tgatggtgaa aacataaaaa tgactccaat tgagtataaa ataattgaac
     3181 ttcttttaga aaataaagga cgagttttct caatagatga gatatacgaa aaagtatgga
     3241 atgaggaaag ttttaattca gaaaatacag tagcagtaca tatcagacga ataagagaaa
     3301 agattgaaat aaatccaaaa gaaccaagat ttttaaaggt ggtgtgggga gttggttata
     3361 agattgaaaa attttagtgg aaaaattata aaagaaaaga gtttaatatt taattgcatt
     3421 ttgattttag tcatttttac atttacacaa atgttaggaa ttttaatatg ttttaatttt
     3481 ttctctgaga gtttaattta ctctatgggg attatgcttt tcttaaactt tattttatat
     3541 aaaatactga caatgtagat gaggtgggca acttggagaa atatagagta ttaaagttag
     3601 tttcattaat cataatatct atctcatttc cattaactat attgttggtg acaataggac
     3661 ttgctgagcc taaatacaat atacaaaaaa cttctacaaa gagtgggatt tttgatatat
     3721 ctgatgattt ttatgatagt aatatatttg acgaaggaac aatggcaagt ctattaccca
     3781 agtttaagct atctgtaggt ggtaaattaa ctagtaaaga aaaaggtaaa ttccaacaag
     3841 aaggtaaaag tatagattta agtagtagtg attctgagta tgataaaatc atgattaatg
     3901 aacaagcttc tgaagaatat ttaagttatc taaaaaatat aaaagtgtat gttattaata
     3961 catacacagg agtattttat acaaatacgt catatgctag tttatatgat tttaaacaaa
     4021 aaactaagag ctattgtaat gtagagataa taaataagat aggaaagagc tcatatatta
     4081 aaacaataaa tggagaaaaa tttgaactga ataatctgag tctggaacta aatgaagtag
     4141 atgaaggttt tgaggcatat gtatcttttc cagaagagcc aactatagaa gatggaatag
     4201 tatacactaa ttttcaaata tttaaacaag ctacagaaaa agtaagatta ttttttgtag
     4261 ctagtttaag tttagcaatt atatgtttat tatctataat tttatatatc aaaataaaag
     4321 gtgaagtttt aaaaagaaat aatgtatttt tactaatata cagtaagata cctatggaat
     4381 ttaatgtaat attagtatct atttcaattg caattttaac tatatatgct cttgctgtat
     4441 cttatcatat tgatgtaatt gcattagttt ctttatcttt actgatagta tcaaataata
     4501 tattttttat aaatgtgcaa ttgagctatt tagaaaataa aatgtgtata tttaagacaa
     4561 gtattatagt aagagtgatt ttatggttaa taaaaactgt aagggaggtc agtaacgcta
     4621 taaagaaagt atctttagca aggaaagtta ttgttatagt gataatatct ttagctttaa
     4681 tcatggcaat tagcactcga agtataggta tgggattact gttttctata tgtatttttt
     4741 taggatttac aatatatata actaaaagac tttcatatct tagttacgta atagaaggta
     4801 cagaaagaat aaaaaaggga gaattagatt ataagataaa aattactggg aatgataatt
     4861 ttacgtcttt agctgaaaat ataaataata ttggagaagg tcttgataga gctatagaag
     4921 agcaagtaaa aagtgaaaga atgaagtctg accttataac aaatgtatct catgatttga
     4981 aaactccact tacttctata ataaattatg tagatttaat taaaaaagaa gaatcaatac
     5041 aaccagagta tataaatgat tatataaatg tacttgagtc aaagtcaaaa agactaaaat
     5101 tattgataga agatttattt gaagcgagta gagtaagtag tggcaatata gaattacaaa
     5161 ttagcaagat tgatttagtg caactattaa gacaaagtat aggtgaactt gaagaaaaat
     5221 tatctaaaaa taatttatat ttaaaattaa atgttccaaa tgataaggtg tatatatggg
     5281 cagatggaag aagaatgtat agagtatttg aaaatctttt atctaatata gcaaaatatt
     5341 ccttagaaga aactagagtc tatattgatg tatatgacta tggtgaaaat gtaaaggtaa
     5401 ctatgaaaaa tatatcttct tatgaattaa attttgaccc aagtgagatt atggaaagat
     5461 ttaaaagagc tgatgaatca aggaatactg aaggaagtgg attagggctt gctattgcaa
     5521 gagatttagt agctttacaa ggtggaaaat tttatataga aatagatgga gatttattta
     5581 aagcaaattt agagtttcaa aaatatgaag aagaaataac aaatatggaa tgagatagta
     5641 tttaagtata tatatttttt tactgtcgaa agcttttatt ataatatatt agaatattta
     5701 cagtagagaa tgaagagtaa aaacagagta actttaagtc actctgtttt ttatttaaaa
     5761 tcaataatat aacaacttaa attaaaattg tacacatagt tttaaaataa cttatacaat
     5821 aaaacattat ccaaatatca caagataatt ccaaataaat atatagatat cactcctgta
     5881 ataatagaaa taccaataga tttaaactta tatgcaacaa gaagtacaat cataaaagat
     5941 ataattttag ggttagctat agataaatat agactatctc cattaaaaaa tacatcttta
     6001 gcagttaagg aagtaagtat tgctacaggt ataaatttca tgattttttt caaaaaatca
     6061 ggcatctctt tttttgaaaa aattaacata ggaagcactc ttggtagata tgtaacaatg
     6121 tacattccaa ttataataaa aaatatataa ttattattca taagattcct cctttttaca
     6181 gtaagattct tctataaaga aaccaattaa agatgctaaa attgatgcaa ctattattac
     6241 taaattgctt ttgaataatg catataaaat aacagaaata atgattgatg atataaatac
     6301 tacaatataa atcttatttt ttatttgaga aactattaaa gctataaaca tagaagtcaa
     6361 tatgaagcca gaaatagaac tgtctataga tatactttct cctaaaaatg ctccaataaa
     6421 attagctaaa actgatgaaa ttaagcagaa gaaattaaga taaatagcat ttctatcaga
     6481 ccaatttcca gcagtaaatt tttcataatt aactgcaaaa gtttcatctg ttatagtatg
     6541 acaaaatggc aatataaatt ttggactttt attttttatg tacatgttca aattagaact
     6601 cattagaaaa tgtcttaagt taactataaa tgtagtcaaa acaatagatg ttacacttgc
     6661 accagtagaa atcattgaag ctgcaatgaa ttgagaactt cctccaaata ctaaagttac
     6721 cattagtgct atttgaaaag gtgaaagacc agatttttgt aatagtattc ctcctactat
     6781 acctataggt atataaccta agaatatagg aattgaagca ataaagcttt cttttaattg
     6841 ttgagttctt tccacaataa atcactcctt ttgtattaaa tgtattaaag tattcgtaaa
     6901 acagaaaaat agattaattg tataattgca attataatta aaaataaatt tggattaata
     6961 tataaaatac tatacaacaa atagataatc ttaaacggtt attaaatttt atctatttgt
     7021 tattatgatg taataataca tattaatctc tataagttaa ttactatctg gtgtaatttt
     7081 attttaacaa caaaaaaaaa tacacacaat taaaatattg tgtgcaatac aattattttt
     7141 tctcttctaa tagtcttttt aatacgctca aaccagcttt aagttcttct gtactttctg
     7201 tagcacatac agctattctt attgcagaaa ttggtttttc ttttccaaca gcaaaacgtt
     7261 cagaagcata gacctgtaca ccttctttaa gtgcttgtat ctcaaatttt tctgccatta
     7321 ttccatcagg tagaatcaac catctaaata tacattcttc atttcccaaa agattatatc
     7381 cagataaata ttgattaata atcttgtttc ttcttcttgc agatttacgg cgtgcattaa
     7441 ttaatttatc ggcttcacct gatgtaatca tgcgataagc aatttctgtt aaaaaataag
     7501 attgagatag attaatgttg tataatgcgc ttgataatgc ctctcgatac tgtttaggtg
     7561 tagagatata tgctagccgt aaactaggtg caataatttt tgataaactc gtaatataaa
     7621 ttgtttgatt gggcagatag gaagccactg gatttaaatg tgtttcatta agtaaactat
     7681 gaatagcatc ctcaataaca attaaattgt atttagatgc aatatttgca atcatttttc
     7741 gtccattttg tgacattata tgtgtagttg gattttgata atctggtatt atgtatagac
     7801 ctttaatatt ttcattttta caagcatata atagtccttc ttcactaatc tcattatctt
     7861 cttgtttaat tggaattagt tgaatcccaa gcattttagc tgctgtcttt attccaggat
     7921 aagttaatgg gtctacacct attctatctc catgttgaaa caaaccagct aaaatagcaa
     7981 caattgcatt ttgtccacca cttgcaggaa gtaagctatc tgatgtagtt tcaagcccag
     8041 ctttataaat taatttggca atagcttctt tttgccattt agcaccatct ctttgtccat
     8101 attggaatat ggttttaaaa tctatttcct taattatgtg tttaaacaaa gtattcattt
     8161 cttctagtgt gaaatctgga ttcattgtgc ccatttcaat aaatgtaatt ttattattac
     8221 tggacatcaa gaatagattt gaacgtgtat cataagatac aaaagttcca cttcctgtaa
     8281 ctccacttat tagacctttt ttttcacaaa ttttaaaagc tctagagata gtactcacat
     8341 taacatctaa gaaatctgcc aattcacgtt ggggtggtaa tttagtacct ggtaataaaa
     8401 atccattgtt gatatcttgt tctagttgtt ctgcaagcgc cttatataat atttgccctt
     8461 ttgaaggtct ctttcgtttc cagttcatag gataattttc aaaagaatta attggcataa
     8521 gttttcacct cacattatta atttgatttt ttctttatct aaaacaataa attctaaaga
     8581 tacaaataaa aactgatagg aaataattct atcagttttt gtcttttaat tgatttcaaa
     8641 tcttcctata atttttatac cttctttatc ataaagaggg attgtttttt taaatatatt
     8701 aaaatttctt tttcttgtat ataaaacagc ttcttctggt gtctttggtt gattatcaca
     8761 atcgtacaaa tctctttttt ttacgtagcc gactttttta cctctaccta ttgtttgtat
     8821 aagttctggt tcaatggaat ttccatttga gtctattata tgtgtaccat aggtttctcc
     8881 atttttatta taattaatct taccaatagt atattctaca tcttcatttt gtttaaaatt
     8941 ggagttgata gaaaatattg accctattat tataaaggtt aataaaaact taagacctaa
     9001 attaattttc tttttatctt gattaaacat agaatctaac ctctttttta aaataatatt
     9061 ttttttattt agaaactgag atacgaatga tgaatacttc aaagattttt gatactttat
     9121 tgtatctaat attatatatg catactcttt aatttcactc gtggtacact tgtcaatcac
     9181 aatttcatca caagataatt cacataattc atgaaaatat ttttttaata agtataaaat
     9241 tggattgaac caatatatga tacaaattat actaattaga agcttaaata agttatcttt
     9301 tcttttataa tgaattaatt catgtttaaa gatgaatctt aactctttat tattgtactt
     9361 tttttctgga attattattt tacagcgtgt taaacctata atggcaggag aataaatacc
     9421 tttaacctta tatatctgaa gttttttatt tatacttagt tcttttgctt gttcatctaa
     9481 gatactagta atatctattt ctaaaatttc ttttttaaaa ttttctatgt aattataaaa
     9541 tttaaaattt gttcttaaat agtaaaaaga gattgctata attcctaata tcc
//
LOCUS       DAEHWM010000121         9483 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.124, whole genome shotgun sequence.
ACCESSION   DAEHWM010000121 DAEHWM010000000
VERSION     DAEHWM010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9483)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9483)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9483
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.124"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            66..821
                     /locus_tag="KNP36_003312"
     CDS             66..821
                     /locus_tag="KNP36_003312"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HBF0875160.1"
                     /translation="MLKVIISGYNGTMGRVLAECVKKDNELELVCGVARSADEKGHHS
                     DTKLYKTMTDVTEKTDVIIDFSHHETLEPILSYALKNNTPVVLATTGYDENDLNKIEE
                     ASKNIPILLSSNTSLGVNILIKLVKDASKMLEGFDIEIIEKHHNRKEDAPSGTATMIA
                     NAIREVLPESENTHGRYGRDCKRKPNEIGIHSIRGGNIISDHDVVFAGDNEVLTLSHH
                     SQSDEVFANGSIVAAKFLIGKQSGLYKMSDILG"
     gene            complement(1328..3004)
                     /gene="bclA2"
                     /locus_tag="KNP36_003313"
     CDS             complement(1328..3004)
                     /gene="bclA2"
                     /locus_tag="KNP36_003313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA2"
                     /protein_id="HBF0875161.1"
                     /translation="MSDISGPSLYQDVGPTGPTGATGPTGPTGPRGATGATGANGITG
                     PTGNTGATGANGITGPTGNMGATGANGTTGSTGPTGNTGATGANGITGPTGNTGATGA
                     NGITGPTGNKGATGANGITGSTGPTGNTGATGANGITGPTGNTGATGATGPTGLTGAT
                     GATGANGITGPTGNTGATGANGVTGATGPTGNTGATGPTGSIGATGATGTTGATGPIG
                     ATGATGADGEVGPTGAVGATGPDGLVGPTGPTGPTGATGANGLVGPTGPTGATGANGL
                     VGPTGATGATGVAGAIGPTGAVGATGPTGADGAVGPTGATGATGANGATGPTGAVGAT
                     GANGVAGPIGPTGPTGANGVAGATGATGATGANGATGPTGAVGATGANGVAGAIGPTG
                     PTGANGATGATGATGATGANGATGPTGATGATGVLAANNAQFTVSSSSLVNNTLVTFN
                     SSFINGTNITFPTSSTINLAVGGIYNVSFGIRATLSLAGFMSITTNFNGVAQNNFIAK
                     AVNTLTSSDVSVSLSFLVDARAAAVTLSFTFGSGTTGTSAAGYVSVYRIQ"
     gene            complement(3382..3921)
                     /gene="hpt"
                     /locus_tag="KNP36_003314"
     CDS             complement(3382..3921)
                     /gene="hpt"
                     /locus_tag="KNP36_003314"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HBF0875162.1"
                     /translation="MDIETKKWEVLYSEEKIKDKLRELGAIIEKDYKDKNLMVVSLLK
                     GSFIFCADLVRNINLPLRVNFMTTSSYGNNEESTGRVKVVSDVTTDIAGYDVLVVDDI
                     TDSALTMDFVLKHLKAKNPASLKCCVLLDKPSRRKVDLVPDYCGFEIEDKFVVGYGFD
                     FGDYYRNVPYIFNVTDEDR"
     gene            complement(4249..5556)
                     /locus_tag="KNP36_003315"
     CDS             complement(4249..5556)
                     /locus_tag="KNP36_003315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine dehydratase subunit alpha family protein"
                     /protein_id="HBF0875163.1"
                     /translation="MRDIRKELVEMLKAEVKPAVGCTEPVALALACAKAKELLGEEIV
                     ENRMLVSPSIYKNGMCVGIPGTERLGLKIAAALGIVGGHSENGLSVLETLTKEEVKIA
                     EDYMDNTPLSITPADTREKVFIEVVLKGKNHIAKVRIRTKHDNFTFLEKDGEVLLDNE
                     PKVSASNDAAEKAESLMDTVTIQELIKNVEEIDFKDIEFLLDGVKMNEEMAEYGLKQK
                     TGIGVGYGIKKSIEEGLLGNDVINYAMMLTAGASDARMAGVKMPVMSSNGSGNHGLTA
                     ILPIVAYNKKFPQSDERLAKALAISHLVTGYIKNYTGRLSAVCGCGVAASTGATAGIS
                     WLMNGTEKQIEGAIENMIADLSGMICDGAKAGCALKLSSAASAAIQSAIIAKQDCFVP
                     PLNGIVGSSVEQSIQNLGRVSDKGMSITDEIILNVMNDMNKVD"
     gene            complement(5981..7756)
                     /locus_tag="KNP36_003316"
     CDS             complement(5981..7756)
                     /locus_tag="KNP36_003316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="HBF0875164.1"
                     /translation="MMIMIGLEYIKSDIQNIAEAIVSVLNIDVTIVNKELFRIAGTGV
                     YIDKIGEKVDKYTAFKKSLTEQITILIDDPKSSDICRECYKSGACVEFAEVCCPIICD
                     GDSHGVIGLIAFTKEQAQIIENNKSGLINFLGKMADLISNKLKAQIKTYELELEKKKL
                     ETLLNNMDKAVVSIDVDGKIDKYNSKFKELFNIKDSITGKNIFVELDFIKKPSINNFK
                     KDKSCSFFYKRYGYDSKGIYNINKIVLKNELKGYVIDFIDKRDAIKNYNKMNKDYRIK
                     LENIIGESVAIRNSKKEALIASKSTSTVLITGESGTGKELFARAIHNHSNRVDNPFIA
                     VNCAAIPDNLLESELFGYEEGAFTGAKKGGKLGMFEVAHKGSIFLDEIGDMSLHLQSK
                     LLRVLQEKELNKIGSKSNVSIDVRIIAATNKDLERMVQNGTFREDLYYRLNVIPIKLP
                     SLRERKEDIPLIIKHMVKEYSKKLDKNVIDIDSRVVDAMMEYKWPGNIRELQNIIEYS
                     VNMSSSSIITMNVIPQKIKNTSVEELEVKSDRIIPLDELEKIEIIKALNKYKDYKKDK
                     ELTAKALGISRATLYRKIEKYNIIS"
     gene            complement(7753..7890)
                     /locus_tag="KNP36_003317"
     CDS             complement(7753..7890)
                     /locus_tag="KNP36_003317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875165.1"
                     /translation="MEINYELIIIVMLFVILMSIQFTLNKIYLILKEIRQILMLKKNK
                     E"
     gene            complement(7968..8537)
                     /locus_tag="KNP36_003318"
     CDS             complement(7968..8537)
                     /locus_tag="KNP36_003318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBF0875166.1"
                     /translation="MKSILCQINKQPVKAKYTSDELECFLDTIEYNVGDKILLVGHIG
                     NLGKRLRGLGTSVTILENSNYEDVCYSLVYNENCNVVKGKLEFLPFDDNQFNKIIIVD
                     QFNVITDCEKASSEIQRVLKGNGEVILEDLNLKNLKVKLNYLKHKFCGSVAKIHYPHE
                     VFNIFSRLNFDGMIKESNKLKYIYVGKRR"
     gene            complement(8721..9356)
                     /locus_tag="KNP36_003319"
     CDS             complement(8721..9356)
                     /locus_tag="KNP36_003319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HBF0875167.1"
                     /translation="MIAVKDENNVVNLRGELDNKLEFSHEIFGEKFYNMKIKINRLSD
                     SFDILPMTVSERLLQDIDLDKQNLVNVVGQLRSYNKTLNNKNRLVLTVFVREIKSIDE
                     ENKDPNSIFLDGYVCKEPVYRKTPLGREITDLLVAINRPYNKSDYIPSIVWGRNAKFA
                     KNLKVGDRIQLWGRVQSREYEKKIDENNVVKKMAYEVSISKIKKLDENNNE"
BASE COUNT         2815 a         1787 c         1134 g         3747 t
ORIGIN      
        1 atattagtga taaaataaac ttatagaaat ataacaaatt tttattaatt tcataggagg
       61 aatttatgtt gaaagttata attagtggct ataatggaac aatgggaaga gttttagcag
      121 aatgtgtaaa aaaagataat gaattagagt tggtttgtgg tgtagctagg tctgctgatg
      181 aaaaaggtca tcatagtgat acaaagcttt acaaaacaat gactgatgta actgaaaaaa
      241 ctgatgtaat aatagacttt tcacatcatg agactttaga gccaatattg tcatatgctc
      301 taaaaaataa tacacctgta gtattagcta ctactggata tgatgaaaat gacttaaata
      361 aaatagaaga agcatcaaaa aacattccta tattattatc atcaaataca tctcttggag
      421 tgaatatatt aataaaatta gttaaggatg cttcaaagat gttagaaggt tttgatattg
      481 aaatcataga aaaacatcac aatagaaaag aagacgcccc tagtggaact gctactatga
      541 tagctaatgc aattagagaa gtcttgcctg aaagtgaaaa tacacatggt agatatggta
      601 gagattgtaa aagaaaacca aatgaaattg gaatacactc tataagaggt ggcaatataa
      661 tcagcgacca tgatgttgta tttgcaggtg ataatgaagt tcttacatta agccatcatt
      721 ctcaatctga tgaagtattt gcaaacggtt ctatagttgc agctaaattt ttaattggta
      781 agcaatctgg gctttataaa atgtcagata tattaggata agttttgtac ataataaatc
      841 tcaatctatt taggtattca tattcatcaa tttgaatatc taattgattg agatttctat
      901 tctaaaagtt tataaatttt atgtttacct tttaaatata atcatttttc ttaaagatta
      961 tcttatttat tggtatatgg aattatattg tttattattt tataatctct tcatcatata
     1021 aacctattaa atattatcct atttattggt atatggaatc atattgttta ttattttata
     1081 atcttttcat catataaacc tattaaatat tatcctaatt tattggtata tgaaatcata
     1141 ttgtttatta ttttatagtc ttttcatcat ataaacctat taaatattat cctatttatt
     1201 ggtatatgaa atcatattgt ttattatttt atagtctttt catcatataa acctattaaa
     1261 tattattcta tttattggta tatgaaatca tattgtttat tattttataa tcttttcatc
     1321 atataaacta ttgtattcta taaactgata catatccagc tgcagaagta cctgtcgtgc
     1381 ctgaaccaaa tgtaaaactt aaagtaacag ctgctgctct agcatcaact aaaaagctta
     1441 aacttacact tacatctgat gaagtaagtg tatttactgc ttttgcaata aagttatttt
     1501 gagctactcc attaaagtta gtagtaattg acataaatcc tgcaagtgaa agtgtggcac
     1561 gtataccgaa agatacattg tatatccctc caactgcaag atttatagta ctacttgttg
     1621 gaaaagttat attagttcca tttataaatg atgaattaaa tgtcactaat gtattattca
     1681 ctaaacttga agaggacact gtaaattgtg cattgtttgc tgctaacact cctgttgctc
     1741 cggtcgctcc ggttggacct gttgctccat ttgctcctgt tgctccggtc gcccctgttg
     1801 ctcctgtcgc tccatttgct ccagttgggc ctgttggtcc tatcgctcct gctactccat
     1861 ttgctcccgt tgctcctact gctccggttg ggcctgttgc tccatttgcc cctgttgctc
     1921 ctgtcgctcc tgttgctcct gctactccat ttgctccggt tggacctgtt ggacctattg
     1981 gacctgctac tccattcgct ccggttgctc ctactgctcc cgttgggcct gttgctccat
     2041 ttgcccctgt tgctcctgtc gctccggttg gacctactgc tccatctgct cccgttgggc
     2101 ctgttgctcc tactgctcct gttggaccta ttgccccagc tactcctgtt gctcctgtcg
     2161 ctcctgttgg acctaccaaa ccatttgctc cagttgctcc ggttgggcct gttgggccta
     2221 ccaaaccatt tgctccagtt gctccggttg ggcctgttgg gcctgttgga cctaccaaac
     2281 catctggacc tgttgctcct actgctcctg ttggacctac ctctccatct gctcctgttg
     2341 ctccggttgc tcctattggg cctgttgccc cagttgttcc tgttgctcct gtcgctccta
     2401 tacttccggt tggacctgtt gctcctgtat ttcctgttgg gcctgtagca cctgttactc
     2461 catttgctcc ggttgctcct gtatttcctg ttggacctgt tattccattt gctccggttg
     2521 ctccggttgc tccagttagt ccggttggac ctgttgctcc agttgctcct gtattccctg
     2581 ttggacctgt tattccattt gctccagtcg ctcctgtatt tcctgttggt cctgtagagc
     2641 ctgttattcc atttgctcca gttgctcctt tgtttcctgt tggacctgtt attccatttg
     2701 ctccggttgc tcctgtattc cctgtcggac ctgttattcc attcgctcca gtcgctcctg
     2761 tatttcctgt tggtcctgta gagcctgttg ttccatttgc tccagtcgct cccatatttc
     2821 ctgttggtcc cgttattcca ttcgccccgg ttgctcccgt atttcctgtt ggacctgtta
     2881 ttccatttgc tccggtcgct ccagttgcac ctctaggccc cgtcggtcct gttggaccag
     2941 tagcacctgt tggccctgtt ggacctacat cttgatataa acttggacct gaaatatcac
     3001 tcatataatt aatcctcctt ttttaaagtt agagtattac tctataaata ttgagtatta
     3061 ctctatataa ttatatgaat cgacaatttc ttatgtgata atgtatctat ttgcttatat
     3121 caacatatat gctttgattc ttgaatttca ttactttttt gtaaaatctt ttacaattat
     3181 tagtactctt ttacaattat taatacaatt aaaaaactca ttttccatca attatttaaa
     3241 atttttttat tatgttataa aaaatagata attaaattgc ataaaattaa tttaatacta
     3301 ctttaattac tttgtaaata aaaaaacctc aacacgatta ataaaaatca tattaaggca
     3361 tccacaaaat tatataattg cttatctatc ttcatcagta acattgaata tataaggaac
     3421 atttctataa taatcaccaa aatcaaaccc atatccaacc acaaacttat cttctatttc
     3481 aaatccacaa taatctggca ctaaatcgac ttttcttctg cttggtttat ccaaaagaac
     3541 acaacatttt aaactagcag gatttttagc ttttaaatgt tttaacacaa aatccatagt
     3601 aagtgcagaa tcagtaatat cgtctacaac caaaacatca tatcctgcta tatcagtagt
     3661 cacatctgaa actactttaa cccttccagt actttcttca ttgtttccat aactagatgt
     3721 agtcataaaa ttaactctaa gtggtaaatt tatatttcta actaagtctg cacaaaatat
     3781 aaagctacct tttaatagag aaactaccat aagattttta tctttataat ctttttctat
     3841 aattgctcct aattccctta atttatcttt aattttttct tctgaataca atacttccca
     3901 tttttttgtt tctatatcca taaaaagacc tccaattgta ataatccttc ttaattttat
     3961 aagagattgc tcactttttc aatactctta ttcaatatta gtcaatatta ttgagttttt
     4021 atgttcattc aacaattatt aacaatgtat cttatatttt aagtagttca tatatccaca
     4081 ctaaattaca tactatatat tttagacaaa aaaagaaaaa acttgcacta acaagttttt
     4141 tctattatac ataaatttat acataatcat attttattag agggtactaa ttaaatttat
     4201 ttatgctatt tttgttatac ctcataatac aaaacatatt ataaagtact agtcaacttt
     4261 attcatatca ttcattacat ttaagattat ctcatctgtt atagacatac ctttgtcact
     4321 tactctacct aagttttgta tactttgctc aacacttgaa ccaactatac catttagtgg
     4381 tggtacaaaa caatcttgct tagctattat agcactttgt atagctgcag atgctgcaga
     4441 agataatttt aatgcacaac cagctttcgc accgtcacat atcattccac ttaagtcagc
     4501 tatcatattt tctatagctc cttctatttg cttttcagta ccattcataa gccaagagat
     4561 accagcagtt gctccagtag aagcagcaac accacatcca catacagcag ataatcttcc
     4621 tgtatagttc ttaatataac cagttactag atgagatata gctaaagctt ttgctagtct
     4681 ttcatcagat tgtgggaatt ttttattata agcaacgatt ggaagaattg ctgttaatcc
     4741 atgatttcca cttccatttg aactcataac aggcattttt acccctgcca ttcttgcatc
     4801 tgaagctcca gcagttaaca tcattgcata atttataaca tcattaccta aaagaccttc
     4861 ttctatagac tttttaattc catacccgac accaatacca gttttttgtt ttaatccata
     4921 ttcagccatc tcttcattca tttttactcc atctagtaaa aattctatat ctttaaaatc
     4981 aatttcttct acatttttta ttaattcttg tatagttact gtatccatta aactttcagc
     5041 tttttctgcc gcatcatttg aagctgatac ttttggttca ttgtctaata atacttctcc
     5101 atctttttct aagaacgtaa aattatcatg tttagttctt attctcactt tagcaatatg
     5161 attttttcct tttaacacaa cttctataaa tactttctct cttgtatcag caggtgttat
     5221 tgatagtgga gtattatcca tataatcctc agctatttta acttcctctt ttgttagagt
     5281 ttctaacaca cttaatccat tttcagaatg tccacctact atacctagag ctgctgcaat
     5341 ttttaatcct aatctttcag tacctggtat acctacacac ataccatttt tatagatact
     5401 aggactaact aacatacgat tttcaactat ttcttctcct aataattcct ttgcctttgc
     5461 acatgctaga gctaaggcta ctggttcagt acaccctact gctggtttaa cttctgcctt
     5521 taacatttcc actaattctt ttcttatatc tctcattata tataaacctc ccaattaagt
     5581 ttagatttag tactcaaata attagttaaa taatttctta tctatattta tagcaaaata
     5641 catgccatat tttttatatc tttttatatt tttagtctta tattctataa ccattggtat
     5701 gactgcctct atttatgtat tttttttatt tgtatagagt atttatattc tttaaaatgg
     5761 agaaacatat gacaatttcg caaaaagaca aaaaaaagtc tcaaaatgag attctatatc
     5821 attttgagac ggctcaaata tattattttt taacttataa aaaccatttt ttaattcata
     5881 aaaaaagatt ctgcaaaaca cttatagtat aagtttaaag ctttctttaa agttatgaat
     5941 ttagaaaaat ttaaatttta tatagctttt tattatatta ctatgaaatt atattgtatt
     6001 tttcaatttt tctatataat gtagctcttg atattccaag tgctttagct gttaattctt
     6061 tatctttttt ataatcttta tacttattta aagcttttat tatctcaatc ttctctagtt
     6121 catcaagtgg aattatccta tcgcttttaa cttctaactc ttctacagag gtattcttaa
     6181 ttttttgagg aattacattc attgtgatta ttgaagaaga agacatattc acactatatt
     6241 caataatatt ctgcaactct cttatattcc ctggccactt atattccatc atagcatcaa
     6301 caaccctgct atctatgtca ataacatttt tatctaattt ttttgaatac tctttaacca
     6361 tatgcttgat tataagtggg atatcttctt ttctctctct taaacttggt aattttatag
     6421 gtataacatt taatctataa tataaatctt ctctaaaagt gccattttga accattcttt
     6481 ctaaatcttt atttgtagca gcaataattc ttacatctat tgaaacattt gatttacttc
     6541 caattttatt aagttccttt tcttgtaata ctctcaataa ctttgactgt aaatgcaaac
     6601 tcatatctcc tatttcatct aaaaatatac ttcccttatg agctacttca aacattccaa
     6661 gctttccacc ttttttagct ccagtaaaag ctccctcttc atatccaaat aattcactct
     6721 ctaataaatt atccggtata gcagcacagt ttacagctat aaaaggatta tctactctat
     6781 tgctatggtt gtgtatggct cttgcaaata gctccttacc cgttccactt tccccagtaa
     6841 taagtactgt tgatgttgat ttagaagcta ttagggcttc ctttttagaa tttcttatag
     6901 ctacactttc tccaattatg ttttccaatt ttattctata atctttattc atcttattgt
     6961 agttttttat agcatctctt ttatctataa aatcaataac atatcccttt aactcatttt
     7021 ttaatactat tttattgatg ttgtatattc ccttcgaatc atatccgtat cttttataaa
     7081 aaaaactaca ggatttgtcc ttcttaaagt tatttataga aggtttcttt ataaaatcta
     7141 actcgacaaa tatgtttttg ccagttatac tatcttttat attgaaaagc tctttaaatt
     7201 ttgaattata tttatcaatt tttccatcca catcaataga cacaacagct ttgtccatat
     7261 tgtttaatag tgtctctaat tttttctttt ctaattcaag ctcataagtt ttaatttgtg
     7321 cttttaattt attagatatt aggtctgcca ttttgcctaa aaagtttata agaccacttt
     7381 tattattttc tataatttgt gcttgttctt ttgtaaaggc tataaggcct ataacaccat
     7441 gagaatcgcc atcacatata ataggacaac acacctctgc aaactctaca caagccccac
     7501 ttttatagca ttccctacat atatcactac tctttgggtc atcaattagt attgtaatct
     7561 gttctgtaag tgatttttta aaagccgtat atttatctac tttctcacct attttgtcta
     7621 tatatactcc tgtacctgca atcctaaata actccttatt tactatagtt acatctatat
     7681 tgagtactga tactatagct tcagctatat tttgaatatc agattttata tattctaaac
     7741 ctatcataat catcattcct tatttttctt tagcataagt atttgtctta tttctttaag
     7801 aatcaagtat atcttattta aagtaaattg gattgacatc aggattacaa agagcataac
     7861 aattattatt aactcataat ttatttccat ctaaacatct ccttataaca aaagactagg
     7921 cttaacctag tcttttatat tatatccata tttatatttt aactcattta tcttcttttt
     7981 cccacataaa tatattttaa tttatttgac tctttaatca taccatcaaa gtttaatctt
     8041 gaaaatatat taaatacttc atgtggatag tgaatctttg caacagaacc acaaaattta
     8101 tgtttaagat agtttaactt aacttttaaa ttttttaaat ttaaatcctc taatataacc
     8161 tctccattgc cctttaacac tctttgtatt tcagatgaag ctttttcaca atctgtaata
     8221 acattaaatt ggtcaactat tattatcttg ttgaactgat tatcatcaaa tggtagaaac
     8281 tctaacttac ctttaactac attgcaattt tcattataca ctagagaata acagacatct
     8341 tcataattac tattctccag tatagttaca gaagttccaa gacctctcaa tctcttgcct
     8401 aggtttccta tatgaccaac aagcaatatt ttatcaccta cattatactc aattgtatcc
     8461 aaaaaacatt ctaattcatc agatgtatat ttagctttaa ctggctgttt atttatctga
     8521 cataatatgc ttttcacaat gcttcacctc ttcatttcct caattataaa ttatgtacag
     8581 attacattat aataaatggc gagcaactat tcaagagata tttcattagt atttttttaa
     8641 acaatcttta tacattttaa tatgatatta taccaaattt attaggattt tattcataaa
     8701 aatcagtcta ttttttatgt ttattcattg ttattttcat ccaatttttt tattttcgat
     8761 atggatactt catatgccat ttttttgacc acattatttt catctatttt tttctcatat
     8821 tctctacttt gaaccctacc ccaaagctgt attctatcac caacctttag attctttgca
     8881 aatttagcat ttctacccca aactattgat ggtatataat cagatttatt ataaggtctg
     8941 tttatagcaa ctaataaatc ggttatttcc cttcctaaag gtgtcttcct atacacaggt
     9001 tccttacata catatccatc taaaaatata ctattagggt ctttattttc ctcgtctata
     9061 ctttttattt ctctgacaaa cactgtaagc actaatctat ttttattatt taatgttttg
     9121 ttatatgatc ttaattggcc tacgacattg actaaatttt gtttatcaag gtcaatatct
     9181 tggagaagtc tttctgatac agtcattgga agtatatcaa aagaatcgct tagtctgttt
     9241 atttttattt tcatattata aaatttttct ccaaatatct catggctaaa ttctagctta
     9301 ttgtctaact cccctcttaa gtttactacg ttattctcat ctttaacagc tatcatattt
     9361 tatccctcca caattgttaa ttcttatatt tctggtatca gcttatataa taaatatatt
     9421 tataagggat gtattttatt acaaatcttt gattgctgtt taaaagtttt tatttagtta
     9481 taa
//
LOCUS       DAEHWM010000122         9191 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.125, whole genome shotgun sequence.
ACCESSION   DAEHWM010000122 DAEHWM010000000
VERSION     DAEHWM010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9191)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9191)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9191
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.125"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            393..1598
                     /locus_tag="KNP36_003320"
     CDS             393..1598
                     /locus_tag="KNP36_003320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase"
                     /protein_id="HBF0875168.1"
                     /translation="MSKKVLIMSASTGGGHNRAALAIKEELTSKTLDGEPIECEIIDS
                     LKLVNNTMDKIISRGYEKSAIYTPKAYGSVYRLSETNLLSKNEFKDNLLITFMAKKFK
                     KLIRSEKPDLIIGTHPFPMIALSTLKKNFNLHNNESNAYTEHFYKHYTNTINVPPLIS
                     VLTDYTTHSTWIQNEIDYYIVGHEYVKELLVFDGVEPSKIRTFGIPVEKSFLSHRDKG
                     IVLSELNLSPDKLTVLLMGGSFGAGNIKETLDELLDTDRDFQILVITGKNESLKEKIE
                     KKLMSRYHDKNVCVLGYTDKMNDILASIDVLVSKPGGLTTTEALLKDVPMIVPYYIPG
                     QEEENLDFLSNCGAALRTTKKYNLSILLKVLIDDPSRLEMLKRNIKSIRKSNSAQNIA
                     NLILNIISG"
     gene            complement(1669..1890)
                     /locus_tag="KNP36_003321"
     CDS             complement(1669..1890)
                     /locus_tag="KNP36_003321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875169.1"
                     /translation="MKPIMNLEEHNAMKEKRVKKMKSKDKPKYDDFEDISFSNKKKTK
                     KNVRNKNAEFRNNYKNYQYDYEEDFYEPI"
     gene            complement(2031..2630)
                     /gene="recR"
                     /locus_tag="KNP36_003322"
     CDS             complement(2031..2630)
                     /gene="recR"
                     /locus_tag="KNP36_003322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012634696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HBF0875170.1"
                     /translation="MQVYTGPITRLIEEFSKLPGVGRKTAQRLAFHIINMNTNDVEAL
                     SKAIIDAKREIRYCSICCNITDTDPCSMCSNKSRDSSVICVVEDPRDVAAMERTREFK
                     GQYHVLNGVISPMDGIGPDMLKIKELIQRLGNQEVKEIIMATNPTIEGEATAMYIARL
                     VKPMGIKVTRIAHGLPVGGDLEYADEVTISKALEGRREI"
     gene            complement(2643..2993)
                     /locus_tag="KNP36_003323"
     CDS             complement(2643..2993)
                     /locus_tag="KNP36_003323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HBF0875171.1"
                     /translation="MAKKGFGGGMMPGGGNMNNLLKQAQKMQENMQKAQQELESKEVE
                     ASVGGGAVTVKVNGKKEVIDITIKPEVVDPDDIEMLQDLVLSAVNQALRNIDDIQASQ
                     MSKVTGGMNIPGLF"
     gene            complement(3052..4689)
                     /gene="dnaX"
                     /locus_tag="KNP36_003324"
     CDS             complement(3052..4689)
                     /gene="dnaX"
                     /locus_tag="KNP36_003324"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HBF0875172.1"
                     /translation="MHKALYRAYRPQKFEDVIGQDHIIKTLKNQIYSDNIGHAYLFCG
                     TRGTGKTSTAKIFSRAVNCLNKINEEPCNECEICESVLKDNTMDVVEIDAASNNSVDD
                     IRELRESVKYSPANAKYKVYIIDEVHMLSQGAFNALLKTLEEPPSYVIFILATTEPHK
                     IPATILSRCQRYDFKRVTVKDMTLRMKKICEDEGIDIDDKALNLIARNSQGALRDALS
                     ILDQCMSFGESKIDYKDVVELMGSVNIEQLFELSQCIVEQDTKKSLEILNEFVLWGKD
                     IRNLINDLIDHFRNLMVCKVSSELDEIISLPEETIEQLKIQSKNIDINDLIRILNILS
                     ITQDDIKSSSNPRVLVEITIMKIAQPMFDESKEALIKRVENLEKMIELGNFKSEKIGN
                     NKEKEYEVDREIDVKQENVVYEDVKNEDVILIESSWKNILKQIKKDKKMPIYALLSEV
                     KSFNVYSNMLYVIFDDKFDFAKTRLSSQDTINYLEKTIRDVLNRSFNVKIVLTSEVKD
                     INLEVKEKKDIGEEILKNIVSEEILEIKDSIDENESK"
     gene            complement(4766..5030)
                     /gene="ffs"
                     /locus_tag="KNP36_003325"
     ncRNA           complement(4766..5030)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="KNP36_003325"
                     /product="signal recognition particle sRNA large type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01854"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF01854"
     gene            complement(5068..5159)
                     /locus_tag="KNP36_003326"
     tRNA            complement(5068..5159)
                     /locus_tag="KNP36_003326"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(5123..5125),aa:Ser,seq:gga)
     gene            complement(5160..5615)
                     /locus_tag="KNP36_003327"
     CDS             complement(5160..5615)
                     /locus_tag="KNP36_003327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HBF0875173.1"
                     /translation="MESSFYMKEALKEAYKAYNKKETPIGAIIVKDNQIIARAHNLTE
                     TLKDSTAHAEILAIKQASEKLGGWRLTDCDLYVTMEPCIMCSGAIVNSRIKKLIIGTR
                     HVKNSYIEKQHEFKLDYFNNNNVKVAFDVLQEECSIILQEFFKALRKRD"
     gene            complement(5936..7207)
                     /gene="serS"
                     /locus_tag="KNP36_003328"
     CDS             complement(5936..7207)
                     /gene="serS"
                     /locus_tag="KNP36_003328"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HBF0875174.1"
                     /translation="MLDIKRIRENLDDIKKAMERRGEREFDLDAVVELDNKRREILQE
                     VEVMKNELNVNSKKIPQLIKEGKDVTEEKARLKELSDKIKGIDEKVKEVEAKMEYTLM
                     RIPNVPHPEVPQGETDEDNVQIRTWGEPTKFDFEHKAHWDIGTGLGILDFERAGKITG
                     SRFTLYRGLGARLERSLMNFFLNTHTAKHGYTEVLPPFMANRNSFIGTGQLPKFEEDM
                     FKIEGLEYFLIPTAEVPVTNIHANEILDVAELPIKYCAYTPCFRSEAGSAGRDTRGLV
                     RQHQFNKVELVKFVKPEDSYNELESLTHDAETMLQMLGLPYRVVKICTGDLGFTAAFK
                     YDLEVWMPSYNRYVEISSCSNFEDFQARRAGIRFKRDKKSKAEYVHTLNGSGLAIGRC
                     LAAILENYQQADGSVVVPEELRPYMGVDVIK"
     misc_binding    complement(7333..7538)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(7666..8547)
                     /locus_tag="KNP36_003329"
     CDS             complement(7666..8547)
                     /locus_tag="KNP36_003329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HBF0875175.1"
                     /translation="MNFLSLAKTASTNSNITKRTLENMLDNFSDNIPNIIYAIIVFVI
                     GIYISKIVRRMVSKFLIKYGMSKGVNNFIVYGIYISMLSIISLISLGIIGIQTTSVVA
                     VLGAAGFSIGLAFKEILSNLGSGMIILFFKPFNIGDYIQGSGVEGTVSDIQIFSTVLK
                     TPDNKTIIIPNFQLTSNNIINYTHQNKRRIDFSYNISYDSDIDVVKSILNEIFTNEKR
                     ILNDPKPIIGLNSIGNNTMQIVARPWVKTDDYWDVYFDVMEKVKNKFDENDIKVPFVP
                     SSLLFNNTGNLNTMDKR"
     gene            complement(8559..9068)
                     /locus_tag="KNP36_003330"
     CDS             complement(8559..9068)
                     /locus_tag="KNP36_003330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HBF0875176.1"
                     /translation="MNSNERRSKLIDILKESKHPVKGGTLAELLNVSRQVIVQDIALI
                     RARGFEIIATPQGYIIYNQPYFTKQIKCKNHKDSKEIYDELKIIVDLGGIIKDVIVNH
                     PTYGQITAELNIYSKMDIDNFMKKVETNEFKQLSVLTECSHIHTIEAIKEETIEAIVK
                     ELKDNGILS"
BASE COUNT         2943 a         1598 c          973 g         3677 t
ORIGIN      
        1 ttcctttttt caaggacaag taatactata tcatctttat ctattctagt caatataatt
       61 ttttactttt tttatttttt ttatttatca tgtattcttt atatttaatt tttaaaactt
      121 aatgctaagt aaacctgttt atttcataaa actaatatat attctatgct ctattttcct
      181 ttttattcta tatttaaatt ttttatttac aagaatattt ttaatataac atatttgata
      241 aaattaattt acatttcttt cacttgtaat ttttgcaatc ttgtattaga ttaatattaa
      301 aaataattta tcaataacct tattcacaaa gacagttttt atatatcaaa atataatata
      361 aatactatgc tacattttag gaggatttta ttatgagcaa aaaagtatta ataatgtctg
      421 cttccactgg tggtgggcat aatagggctg ctctagctat taaagaagaa cttacttcca
      481 aaacacttga tggagagcca attgaatgtg aaataataga tagtttgaaa ttagttaata
      541 atacaatgga taaaataatt tcaagaggat acgaaaaatc tgctatatat actcccaaag
      601 cctatggaag tgtatataga ttatctgaaa caaatctttt atcaaaaaat gaatttaaag
      661 ataatctact aataacattc atggctaaaa aatttaaaaa acttattaga agcgaaaaac
      721 cagacttgat tataggaacg catccttttc caatgattgc tctaagtaca ttgaaaaaaa
      781 actttaattt acataataat gaatcaaatg cttacacaga gcatttttat aaacattata
      841 caaataccat taatgttcct ccgcttattt ctgtattaac cgattatact actcattcta
      901 catggataca aaatgaaatt gattactata ttgttggtca tgaatatgta aaagaattat
      961 tggtgtttga tggagttgaa ccgagtaaaa ttagaacatt tggaatccct gttgaaaaat
     1021 cttttctctc tcacagagat aaaggtattg ttctttctga gttgaattta tctcctgata
     1081 aattaactgt tttacttatg gggggtagct ttggggctgg aaatataaaa gagacacttg
     1141 atgaattact ggatactgat agagactttc aaatacttgt aattactggt aagaatgaaa
     1201 gcctaaaaga aaaaatcgaa aaaaaactta tgtctcgtta tcatgataaa aatgtatgtg
     1261 ttcttggata cactgataag atgaatgata ttttagcttc tatagatgta ttagtaagca
     1321 aacctggtgg acttactaca actgaggctc ttttaaaaga tgtacctatg atagttcctt
     1381 attatatacc aggtcaggaa gaagagaatc ttgatttctt atctaattgt ggtgcagcac
     1441 ttagaactac aaaaaaatat aacttgtcaa tattactaaa agttttaata gatgacccta
     1501 gcagattaga aatgctaaaa agaaatatta aatcaataag aaagtcaaat tcagcccaaa
     1561 atatagctaa tttaatttta aatataattt ctggttgata aaataaataa aatccctata
     1621 gtatatatat tatctattag ggatttttta ttttctaatt atttaatatt aaattggttc
     1681 ataaaagtct tcttcataat catactgata atttttataa ttatttctaa attcagcatt
     1741 tttatttcgt acattttttt tagttttttt cttattagaa aaacttatat cctcaaaatc
     1801 atcatattta ggtttatctt ttgatttcat ttttttaact cttttttctt tcattgcatt
     1861 atgttcttct aagttcataa ttggtttcat gttgcacccc tatcaaaatt tttaaatgat
     1921 ttatacaaca aattatacaa tacagaagaa atttattcaa taaatctaaa tcaaaattaa
     1981 tttgaattta actcaaaaaa ttacaaaaat cgaggtatta acctcgattt ttatatttct
     2041 cttctgcctt ctagtgcttt tgatattgtg acctcatctg catactctaa atcgcctcca
     2101 acaggaagac catgagctat ccgagtgact ttgattccca ttggttttac taacctagca
     2161 atatacatgg ctgtagcttc accttcaata gtaggatttg ttgccattat tatttctttg
     2221 acttcctgat tgccaagtct ttggataagt tcctttattt ttaacatatc tggtccaatt
     2281 ccatccattg gagaaattac tccatttaat acatggtact gtcctttaaa ctctctcgtt
     2341 ctctccatag ctgctacatc tcttggatct tccacaacac atataacact tgaatctcta
     2401 cttttatttg aacacatgct acatgggtct gtatctgtta tattacaaca aattgagcaa
     2461 tatcttattt ctctttttgc atctataatc gctttagata aagcttccac atcattagta
     2521 ttcatattaa taatatgaaa agccaatctt tgagcagtct ttcttcctac tccaggaagc
     2581 tttgaaaatt cctctataag tctcgttatg ggacctgtat aaacttgcat aaataccacc
     2641 tactagaata acccaggtat attcatacct ccagttacct tactcatttg acttgcttgt
     2701 atatcatcaa tatttctcaa tgcttgattt actgcactta aaactaaatc ttgtagcatt
     2761 tctatatcat ctggatcaac tacttctggc ttgatagtta tatctataac ttctttttta
     2821 ccattaactt ttacagtaac tgctcctcca ccaactgaag cttctacttc tttactttct
     2881 aactcttgtt gagctttttg catattttct tgcatttttt gagcctgctt taacaagttg
     2941 ttcatatttc caccaccagg catcattccg cctccaaaac cttttttagc cataaacact
     3001 attcctccta aacttatttt cattttatta ttatatcata atagtatttt attatttact
     3061 ctcattttca tcaatactat cttttatttc taatatctct tcactcacta tgttctttaa
     3121 tatttcctca ccaatgtcct ttttctcttt aacttcaaga tttatatctt taacttctga
     3181 tgtcagtact atttttacat taaaacttct atttaaaaca tctcttattg ttttttctaa
     3241 ataatttatt gtatcttgag agctcagtct agtttttgca aaatcaaatt tatcatcaaa
     3301 tataacatac aacatattag aatatacatt aaaacttttt acttcactta agagtgcgta
     3361 tattggcatt tttttatctt ttttaatttg tttaagtata ttcttccaag atgactctat
     3421 aagtataacg tcctcatttt ttacatcttc ataaactaca ttttcttgtt ttacatctat
     3481 ttctctatcg acctcatact ctttttcttt attattccca attttttcag acttaaagtt
     3541 ccccagttca atcatttttt ctaagttctc aactcttttt ataagagctt ctttactttc
     3601 atcaaacatt ggttgagcaa ttttcattat ggttatttcc actaaaaccc ttggatttga
     3661 agatgacttt atatcatcct gagttattga taatatattt aaaatcctta ttaaatcatt
     3721 tatatctata tttttagact gaattttaag ttgttctata gtttcttctg gtaatgaaat
     3781 tatttcatcc aattctgatg aaaccttaca taccattaaa tttctaaaat gatcaattaa
     3841 gtcatttata agatttctta tatctttgcc ccataagaca aattcattta atatctcaag
     3901 agacttttta gtgtcctgct ctactataca ttgagacaat tcaaataatt gttctatatt
     3961 tacgcttccc attaattcaa caacatcttt ataatctatc ttactttctc caaaagacat
     4021 acattggtct aatatactaa gtgcatctct aagagctcct tgagaatttc tagctattaa
     4081 attaagagct ttatcatcta tatcaattcc ttcatcttca caaatctttt tcattctaag
     4141 ggtcatatct ttaactgtaa ctcttttaaa atcgtatctt tggcatcttg ataaaatggt
     4201 tgcaggtatt ttgtgaggct ctgtagttgc taatataaaa attacatatg atggaggttc
     4261 ctctaaggtc tttaataatg cattaaaagc tccttgagac aacatatgaa cttcatctat
     4321 tatatatact ttatatttag cattggctgg agaatatttc acactttctc taagctctct
     4381 tatatcatct acactattat ttgaagctgc atctatttct acaacatcca ttgtattatc
     4441 ttttaataca gattcgcata tctcacactc attacacggt tcttcattta ttttattcaa
     4501 acagtttact gctcttgaaa aaatctttgc agtagatgtt ttaccagtac ctcttgttcc
     4561 acaaaacaaa taagcatgtc ctatattatc actatatatt tgattcttta aagtcttaat
     4621 aatatgatct tgaccaataa catcttcaaa tttttgtggt ctatatgctc tatataatgc
     4681 tttatgcatc tttttacctc tctttagcaa aattaataaa aaaatccctc attatctaag
     4741 ggattagtct tttatatatt aaatgctgta caccatctat cgacttaatt ccataggcgt
     4801 taccaaaaca gttagctcaa cttaggcacc cccacggcac acaaaagtga tcacttaccg
     4861 ctgcttcctt ccggatctga cggggttcat gagctttcat tgcgcaggac ctaagcatca
     4921 acaccactta tttagggcgg ccctacagaa aataagcctt tagatggaat tcaatcctgc
     4981 tatagcggat tgcaggttac agggcaccgc tacctcccca tctagtacag caaaattaca
     5041 accatattta attactttca ttgtttctgg cggagagagt gggatttgaa cccacgatac
     5101 agttttaccc atatactcgc tttccaggcg agcgccttcg accactcgac catctctcct
     5161 taatctcttt ttctcaatgc cttaaaaaat tcttgcaata tgatcgagca ttcttcttgc
     5221 aaaacatcaa aagctacttt tacattatta ttattaaaat aatctaattt aaactcatgc
     5281 tgtttttcta tatatgaatt ttttacatgt cttgtcccta ttataagctt ttttattcta
     5341 gaattaacta ttgcgccact acacattatg caaggttcca ttgtaacata taaatcacaa
     5401 tcagtcaacc tccaaccacc taatttttct gatgcttgtt ttatcgctaa aatttctgca
     5461 tgtgccgtag agtcttttaa cgtttctgta aggttatgag ctctagctat tatttgatta
     5521 tctttaacta taatagcacc tattggtgtt tcttttttat tatatgcttt atatgcttct
     5581 tttaatgctt ctttcatata aaatgaactt tccataattc ctcccaaaac ttataacaaa
     5641 cttatcttat cataattcat tttataattc aacttaattt tattttgttt atttaattat
     5701 tactatatat agctatattt ttttaaaatt agttctaaaa taatttttag atattcatac
     5761 aagagtgttt tataaaaata tttagtgttt tatgatgaaa attctgctgt gtaaattaac
     5821 ataaaaaaac tatgaaatta atatttataa taatttcata gtttttttat ttattgttta
     5881 ctcataatat attctcttca tcaaagcata ctctatatat acaattaata taaatttatt
     5941 ttataacatc aacacccata taaggtctta attcttctgg aactactaca gaaccatctg
     6001 cctgctgata attttctaat atagcagcca aacatcttcc tattgctaat ccagaaccat
     6061 ttaatgtatg aacatattct gcttttgatt ttttatctct tttaaatctt attcctgctc
     6121 ttcttgcttg gaaatcttca aaatttgaac aagaagatat ttctacatat ctattgtaac
     6181 ttggcatcca aacttctaaa tcatatttaa atgcagctgt aaatcccaaa tctcctgtac
     6241 atatttttac aactctatat ggaagaccta acatttgtaa catagtttca gcatcatgag
     6301 ttaatgattc taattcatta taagaatctt ctggtttaac aaatttaact aattcaactt
     6361 tattaaattg atgttgtcta actaaacctc ttgtatctct tcctgctgaa cctgcttcag
     6421 atctaaaaca aggagtatat gcacagtatt taattggaag ctctgcaaca tctaatattt
     6481 cattagcatg tatattagta acaggaactt cagctgttgg tattaagaaa tactctaatc
     6541 cttctatttt aaacatatct tcttcaaatt taggaagttg accagtccct ataaaactat
     6601 ttctattggc cataaatgga ggtaagactt ccgtatagcc atgcttagct gtatgagtat
     6661 ttaaaaagaa attcattaaa gatctttcta atctagctcc taatccccta tataaagtaa
     6721 accttgaccc agttattttc cctgctcttt caaaatctaa aatacctaga cctgtaccta
     6781 tatcccaatg cgctttatgc tcaaaatcaa atttagtagg ttctccccaa gttcttattt
     6841 gaacattgtc ttcatctgtt tcaccttgtg gtacctctgg atgaggaaca tttggtattc
     6901 tcattaatgt atattccatt tttgcttcta cttcttttac tttctcatca atacctttta
     6961 tcttatctga taactctttc aatcttgcct tttcttctgt tacatctttt ccttctttta
     7021 ttaattgagg tattttttta gaatttacat ttaactcatt tttcataact tcaacttctt
     7081 gaagtatttc tcttctttta ttatctaatt ccactacagc atcaaggtca aattctcttt
     7141 cacctcttct ttccatagct tttttgatat catctagatt ttctcttatt cttttaatat
     7201 ctaacatatt aattcctcct aataattttg ataatataag ttataattcc aacttaattt
     7261 acaaacatta tacttgtaaa ctcttagttt aaacaaattt taaaaataaa aaaagacctc
     7321 cgtttaccct ataaaaggga cgaaaatctt ttatccgcgt tgccacccta attgactata
     7381 ctaaaatgta taatcctctc agacctataa cgtaggtaaa cgtctagctt taactagaag
     7441 ctctagagta gattcaaaaa ccattgtaat gagttttcac catccactca ttctctgaat
     7501 acaatctgtt ttttactatt ttccttcaca gctttttaac taattgtttt atttgataat
     7561 cattatatta tatatattaa catctttcaa tactattatt caaatttttt tagaattttc
     7621 tttaattttt tatattaaat tcattttttc tatttaatta aaaccttatc ttttatccat
     7681 tgtatttaga ttacctgtat tattaaataa taatgaagaa ggaacaaatg gaacttttat
     7741 atcattctca tcaaatttat tttttacctt ttccattaca tcaaaatata catcccagta
     7801 atcatcagtt tttacccaag gtctagcaac tatttgcatg gtgttatttc ctatagagtt
     7861 taaacctatt ataggctttg gatcatttaa tattcttttt tcgtttgtaa aaatttcatt
     7921 taatatagac ttaactacat ctatatcact atcatatgaa atattatatg aaaaatctat
     7981 tcttcttttg ttttgatgtg tgtaattaat tatattatta cttgtcagtt gaaaattagg
     8041 tataattata gttttattat ctggcgtctt aagaacagtg ctaaatattt gtatgtcaga
     8101 aactgtacct tctacacctg aaccttgaat ataatcacct atattaaatg gcttaaaaaa
     8161 taaaataatc ataccagagc ctaaatttga taatatttct ttaaaagcta aacctatact
     8221 aaatccagca gctcctaaca cagctacaac tgatgtagtt tgtatcccta taatacctaa
     8281 gcttatcaat gatataatag ataacataga tatatatatt ccatatacaa taaaattatt
     8341 tacaccttta ctcattccat atttgattag aaactttgaa accatccttc ttactatttt
     8401 agatatataa atacctatca caaatacaat tattgcatat ataatatttg gtatattatc
     8461 actaaaatta tcgagcatat tttctaaagt tctcttagtt atattgctat ttgttgaggc
     8521 agtcttagcc aatgataaaa aattcattca actcctcctt atgataatat tccgttgtcc
     8581 tttaactctt ttactatagc ttctatagtt tcttctttta ttgcctcaat tgtatgaata
     8641 tggctacatt ctgtcagaac cgataattgt ttaaattcat ttgtctcaac tttcttcata
     8701 aagttgtcta tatccatttt agaataaata ttaagttctg cagttatctg accatatgtt
     8761 ggatgattta cgatgacatc ttttataata ccacctaaat ccacaattat ctttaattca
     8821 tcataaattt ctttagaatc cttatgattt ttacacttta tttgttttgt aaaatacggt
     8881 tgattatata ttatatatcc ttgaggtgta gctattattt caaatcctct agctcttata
     8941 agggctatat cttgaactat tacttgccta cttacattta atagttcagc tagtgttcca
     9001 ccttttacag gatgcttaga ttcttttaaa atatctatta atttacttct tctttcatta
     9061 gaattcatat tacaccttct ttccaaataa aaactttacc tatactatat aattttatat
     9121 tttatcttat tataaatcaa tattgacttt atattctatt taatcttaac ttttataata
     9181 aataaaaaag a
//
LOCUS       DAEHWM010000123         9064 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.126, whole genome shotgun sequence.
ACCESSION   DAEHWM010000123 DAEHWM010000000
VERSION     DAEHWM010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 9064)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9064)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9064
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.126"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(250..858)
                     /locus_tag="KNP36_003331"
     CDS             complement(250..858)
                     /locus_tag="KNP36_003331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="HBF0875177.1"
                     /translation="MEKDFFRKNGIDLAKSILGKYLIRKYENKVIVTKIIETEAYMGV
                     NDKGAHVYGNKKTDRTKPLYLDGGHIYVYLIYGMYNCLNLSANIENVPECVLIRGVEP
                     ITSLDEISMNRYNKAYTELSKYQVKNITNGPGKLCKALKIDRSLNSKSIMGEELYISD
                     FYYDDKGKKVFSKDELDIKTSKRINIDYAEEAKDFLWRFYIE"
     gene            complement(967..3705)
                     /locus_tag="KNP36_003332"
     CDS             complement(967..3705)
                     /locus_tag="KNP36_003332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing sensor histidine kinase"
                     /protein_id="HBF0875178.1"
                     /translation="MESKGTLSKNKVYILANGLFLVIALLNINLYTVSINMYRIILLW
                     IFGYSIVYISSFKTDEFINILKVGCLVLVFVSILGVVNLKIQKFQIVLLNLSIINMST
                     FIYLTISKVKKLRISPILIFYSAFVILDYFIRNIFSDINWNMIIILINICISMFNLLY
                     LLNKLDSNIEHYKLIKDLTYFVFFTTIICFVAISKINIVDSDRLIGVIYLLLCNHTYY
                     VYVYSLNNRVVYPYYELDSINKKLSKKSEQLGKINLAIEKDMIIQRTLKNYIDQRKEL
                     LRQALDTIPNVWIVTDYDFNISYTNNKFKDEFSKDMNNYYKILTFIKEDEKVAEKLKK
                     FDNDISIIDKLVELNDKIYLLSLSNNKDESNYLISLNDITNEIKIDEEIRNINKDYEN
                     IILNIPSPILVRSAEGGIKKNKVISINKKYEKSFKCVSSDLVDMTLEQYFETFNIDFF
                     DNREFKRLNLTQEKKAEIVSYNDTANCIVNFVMSDSEGEEHVEEVRVGDYWSDNKLFK
                     LLTFRDITKEINILRTVNEQKIIYEKLLDVIPEAIFLEDLSTSRVLYTNRAFRELFGI
                     SSDVLGVTTQKYRNILVKKYINNLNIGEREKSIHIVNENNHIKEVKMISRTLYFGQKR
                     SRVRIIKDLSVQRESERLKKALIKQRQYDQMKMEFYANISHELKTPLNNIYSSVQLIE
                     NLYKKGKIIDFQDILKEHIKITKQNMFRLLRLIDNIINISQVKSDIYKIKAVNFDIID
                     ITERIVTSISSYAKSKGIDLIFDTDEETVMVGLDPESIERIILNILSNAIKFTLEGGE
                     ILVGIYKKDETVEIIIKDTGVGIDKEKLKDIFNRFKQIENSGISNEFGSGIGLCLTKS
                     LIEIQNGKIYIDSKVGEGTNVKVIFPIKEVVEEVYDNSNYNDNIEKFEIEFFDIYK"
     gene            complement(3853..4644)
                     /locus_tag="KNP36_003333"
     CDS             complement(3853..4644)
                     /locus_tag="KNP36_003333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011987989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HBF0875179.1"
                     /translation="MKLKKLLSVALVSAIAISAVGCSNKEDKKILVGASSNPHAKILE
                     VAKPLLKEKGYDLEVKIFDDYVLPNTALDEGSLDANFFQHIPFLEETVKEKGYKLTYT
                     SKVHIEPMGFYSEKVKSLDELKDGAVIAVPNDATNGARALKLLAKNKLIEVKDGELIT
                     KKDITKNPKNIVIKEMNAEQLPTVLKDVDGAVINSNYALTANLNPTKDAIVIESSDSP
                     YVNIIACRENNKDSDKIKALSEAMNSKEVKKFIQDEYKGSIVPAF"
     gene            complement(4680..5336)
                     /locus_tag="KNP36_003334"
     CDS             complement(4680..5336)
                     /locus_tag="KNP36_003334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875180.1"
                     /translation="MNSLIDFLTTLFPNALLQTLYMVIVPTIVATILGFILAIILVVT
                     KPDGLKPNSTINSALGFIVNIFRSFPFMILIVAMIPITRLIVGTSIGETAAIVPITIG
                     AAPFIARIIESSLNEVDKGLIEAAKSFGATKRQIVFKVMIKEAMPSIVSGITLSIISI
                     LGYTAMAGAVGAGGLGNIALIYGYQRFDTAVMVYTVIALIILVQIIQGVGNLAYKKLK
                     "
     gene            complement(5329..6294)
                     /locus_tag="KNP36_003335"
     CDS             complement(5329..6294)
                     /locus_tag="KNP36_003335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HBF0875181.1"
                     /translation="MISIKNVNKYYGKIQVLKDVSIEIESGEIFGIIGHSGAGKSTLL
                     RCINGLEEYQEGSVLVSDKEVKSLNEKQMRDLRKELGMIFQHFSLLERKTVFDNVALP
                     LECFGYSKAEIKKRVLELLEVVGISEKKNDKPRNLSGGQKQRVAIARALALNPQVLLC
                     DEATSALDPNTTKSILSLLEDINKKLGITIIVVTHQMEVIKQICGRVAIMENGEVLEV
                     GDTEEIFLRNTKGLRKLIGEESIILPKGTNIKILFPKDISNEAIITTMARELNIDVSI
                     IFGKLEQFKDDILGSLIINISDKSGEQVKQYLTSKGIRWEEMINE"
     regulatory      complement(6400..6506)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
     gene            complement(6796..7740)
                     /locus_tag="KNP36_003336"
     CDS             complement(6796..7740)
                     /locus_tag="KNP36_003336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YafY family transcriptional regulator"
                     /protein_id="HBF0875182.1"
                     /translation="MSRAERLIELMITINAKRSFTAGELAEEFSVSKRTILRDLQVLE
                     SIGFPLYSKVGAAGGYHVLKERILPPIAFSESEVKSIFFAYQSLEYYNDLPFEQETIS
                     VLKKFLNCIPNDIQYNIENIRRKFVFWTPDRHCSTPLLKELFNIVMNEFTIKIEYSSK
                     QKNSVRTIVPIGLYAMNGLWYCPAYCIKSESIKEFRVDRIVKILSIENLSSKKYKVLS
                     SIHDYLKNMEVGTDYHIKINLTDEGVKRCETEFLLARGLKILSKGGYIDMYIPKSTLN
                     WVAEYFLTFGKNATIIEPIELKHLIKSKVLELYNHHCI"
     gene            7851..8318
                     /locus_tag="KNP36_003337"
     CDS             7851..8318
                     /locus_tag="KNP36_003337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875183.1"
                     /translation="MENDTIKADDILNYCLSNLDDVVLMDSWGERAIYYNPNGVLKRG
                     VYVLTIKEKDSNNDKGSLVSRPNVYRVNIGLKKETFIEMFGYIPKRPGVGQIVDMDFD
                     FTKLDTIMPHPIYSWMGWICVLSPTEKTFENFKTLIGESYNFAKQKFKKRKNK"
     gene            complement(8488..>9064)
                     /locus_tag="KNP36_003338"
     CDS             complement(8488..>9064)
                     /locus_tag="KNP36_003338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875184.1"
                     /translation="VGLALVLAIGITACTKNNEKPSENTGKNPNESVNNNEGYMNYYS
                     TSYNDYIAGLNRYSIYDTPESINNQFKDKEYPGNEKYLSDVKAAYKDSRDKIQSFVTS
                     LKKDGKTEDTELKKMNDDLIAEGERLVKDIDKRIEKLDKVSDEDMKKGQNDFIKLVHG
                     TEDVGNDIGSGFRKMIKDMNDRLGITGNNKK"
BASE COUNT         2958 a         1496 c          876 g         3734 t
ORIGIN      
        1 tacttataaa ataaactaat tatctataca aattttataa tttttaataa aatacacaaa
       61 aaaattaatt tttatagctc atttcgccaa aatatatctt tctttatatc attaaaataa
      121 ttataaattt attaaatatg tttgtaattc tataaagtta tttttatcaa actaaaaatt
      181 ctataaaaaa ataagataca tacctataaa ataccttcct atagatacat atcttaccta
      241 tataaaaact tattctatat aaaaacgcca taaaaaatct tttgcttctt ctgcataatc
      301 tatatttata cgtttactag tttttatatc taactcatct ttactaaata ctttttttcc
      361 tttatcatca taataaaaat cacttatata taattcttca cccattatac tcttactatt
      421 tagacttcta tctattttta aagctttgca aagttttcct ggtccgttag taatattttt
      481 tacttgatat ttactcaact cagtgtaagc tttgttgtat ctattcatag atatctcatc
      541 taaagaagtt ataggctcta cccctcttat taatacacac tctggcacat tttctatatt
      601 tgcagataaa ttcaagcaat tatacatacc ataaattaaa taaacatata tatgtccacc
      661 atctaaatat aatggcttag ttctatctgt ctttttattg ccatatacat gtgctccttt
      721 atcatttaca cccatgtatg cttctgtctc tatgattttg gtaacaatta ctttattttc
      781 atatttcctt attagatatt tacctaatat tgatttggct aaatcaattc cattttttct
      841 aaaaaaatcc ttttccaaaa tttcacctca taaaatttat ttaaaacgca tcaaatacaa
      901 ctaaagtaat aaataaaatt aactcttatt aatgtgatat atataaacaa taaatttaga
      961 catttattat ttatatatat caaaaaattc tatctcaaac ttttcaatat tatcattgta
     1021 atttgaatta tcatatactt cttcaacaac ctctttaatt gggaatataa cttttacatt
     1081 agttccttct cctaccttac tatctatgta aatcttccca ttttgaattt caatcaatga
     1141 ttttgtaagg cataaaccta taccacttcc aaattcattt gatataccac tgttttcaat
     1201 ttgtttaaat cgattaaata tatcctttaa tttttctttg tctatgccca ctccagtatc
     1261 ttttataatt atctctactg tttcgtcttt tttatatata cctacaagga tttctcctcc
     1321 ttctaaagta aattttatag catttgataa tatatttagt attattcttt ctatcgattc
     1381 tgggtcaagc cctaccataa cagtttcttc atctgtatca aaaattaaat ctattccttt
     1441 agacttagca taactactaa tagatgtaac tattctttct gttatgtcaa taatatcaaa
     1501 attaactgct ttaatcttat atatgtctga cttaacttga gaaatattta ttatattatc
     1561 tattaatctc aataatctaa acatattttg tttagttatt tttatatgtt cttttagtat
     1621 atcctgaaaa tcaattattt ttcctttttt ataaaggttt tcaataagtt gaactgaact
     1681 atatatatta tttaaaggtg tcttaagttc atgagatata ttagcataaa actccatctt
     1741 catttggtca tactgtcttt gttttattaa tgctttttta agtctttcag actctctttg
     1801 cacacttaaa tctttaataa ttctcactct acttcttttc tgtccaaagt ataatgttct
     1861 tgatatcatt tttacttctt taatgtgatt attttcattt actatatgga tactcttctc
     1921 tctttctcct atatttaaat tgtttatgta tttttttact aatatatttc tatatttttg
     1981 tgttgtaact cctaatacat cactagaaat tccgaacaac tctctaaagg ctctatttgt
     2041 atatagtact cttgatgtac ttaaatcctc aagaaaaata gcctctggta taacatccag
     2101 taatttttca tatattattt tttgttcatt tactgttcta agaatattta tctctttagt
     2161 tatatctcta aatgtaagca atttaaagag tttattatct gaccaatagt ctccaactct
     2221 aacttcttca acatgttctt caccttctga gtcagacatc acaaaattaa ctatacagtt
     2281 tgctgtgtca ttgtaactta ctatttcagc tttcttttct tgtgttagat ttaatctttt
     2341 aaattcccta ttgtcaaaga aatctatgtt aaaagtttca aaatattgtt ctaatgtcat
     2401 atcgactaaa tcacttgaaa cacatttaaa actcttttca tattttttat ttatacttat
     2461 taccttattc ttctttatgc caccttcagc acttcttaca agtataggag atggaatatt
     2521 tagtataatg ttttcatagt ctttatttat atttcttatt tcttcatcta ttttgatttc
     2581 atttgtaata tcatttaaac ttattaagta attgctttcg tctttattat tacttaaact
     2641 taacaaataa attttatcat ttaactctac cagtttatca attatactta tatcgttatc
     2701 aaatttcttc aatttttcag caactttttc atcttccttt ataaaagtta atattttata
     2761 ataattattc atatcctttg aaaattcatc tttaaattta ttatttgtgt aacttatatt
     2821 aaaatcatag tctgttacta tccatacatt tggtattgta tccagagctt gtctaagtaa
     2881 ttcttttctc tggtctatgt agttttttaa tgttctttgt ataatcatat ccttttctat
     2941 tgctaaattt atctttccta attgctctga ctttttactt aattttttat tgattgaatc
     3001 aagttcataa tatggataca ctactctatt attaagactg tatacatata cataataagt
     3061 atggttacat aatagtaaat atattactcc tattaatcta tctgaatcta ctatattaat
     3121 cttagaaatt gctacaaaac atataatagt tgtaaaaaaa acaaaatatg ttaaatcttt
     3181 tattaactta tagtgctcaa tgttactatc aagtttattc aacaaatata gtaaattaaa
     3241 catagatata caaatattaa ttaatataat aatcatattc cagttaatat cactaaaaat
     3301 atttcttata aagtaatcta atatcacaaa agcactataa aaaattagta ttgggcttat
     3361 tcttagtttt tttactttag aaatggttaa gtatataaaa gtagacatat taattatgct
     3421 taagttaagc aatacaattt ggaatttttg aatttttaaa tttactactc ctaaaatact
     3481 tacaaaaact aatacaagac accctacttt caatatattt ataaattcat ctgttttaaa
     3541 gctacttata taaactatag aatatccaaa tatccaaagt aaaattattc tatacatatt
     3601 tatagaaact gtatacaaat ttatatttaa aagtgcaata accaaaaata acccattagc
     3661 tagtatatag accttattct tacttaaagt tcctttagat tccatattcc ccaccacttc
     3721 ttcattttta tatagtttta cctataaata tgttaccaca attcttccaa aaaatttgtc
     3781 actttctagt tataaaaaaa aatgagtaaa tatttttaat tttactcatt ttgtagattt
     3841 tgtatattca gtttaaaaag ctggaactat acttccttta tattcatctt gtataaattt
     3901 tttaacttct ttactattca tagcctctga taaagcctta atcttatcac tatctttatt
     3961 attttctcta caagctatta tatttacata tggagaatca cttgattcta ttactattgc
     4021 atccttagta ggatttaagt tagctgttaa agcataatta gaatttatta ctgctccgtc
     4081 aacatctttt aatactgttg gtaattgctc tgcattcatt tcttttatta ctatattttt
     4141 aggattttta gttatatctt ttttagttat aagctctcca tcttttactt ctatcaattt
     4201 attttttgct aataatttaa gtgctctagc tccattagtt gcatcatttg gcacagctat
     4261 aacagctcca tcttttaatt catctaatga cttaactttt tctgaataga atcccattgg
     4321 ctctatatga actttagatg tataagtaag tttatatcct ttctccttca cagtttcctc
     4381 taaaaatgga atatgttgaa agaagttagc atccaaagac ccttcatcta aagctgtatt
     4441 tggaagtaca taatcatcaa atatttttac ttctaaatca tatccttttt cttttaacaa
     4501 aggttttgca acttccaata tctttgcatg tggatttgat gaagctccta ctagtatttt
     4561 tttatcctct ttgtttgaac aacctactgc tgatattgct attgctgaca ccaatgctac
     4621 tgataataat ttctttaatt tcatttttac tccccctctt taaaatgttt ataattaatt
     4681 tattttagtt tcttataagc cagatttcct actccctgga ttatctgaac taatattata
     4741 agtgctatta cagtatatac cattactgct gtatcaaatc tttgatatcc ataaataagt
     4801 gctatattac ctaatcctcc agctcctact gcacctgcca tagctgtata accaagtata
     4861 gatattattg ataatgtaat tccagatact attgaaggca tagcttcctt tatcataact
     4921 ttaaatacta tttgtctttt tgtagctcca aaagattttg ctgcttctat caatccttta
     4981 tcaacttcat ttaatgagct ttctataatt ctagcgataa acggtgctgc cccaatagtt
     5041 attggcacta ttgcagcagt ttcccctata cttgttccaa cgattaatct agttattgga
     5101 atcattgcaa ctataagtat cataaatggg aaacttctaa atatatttac tataaatcct
     5161 aatgcactat ttattgtgct atttggtttt aatccatctg gttttgtaac tactaatatg
     5221 attgctaata taaatcctaa tattgttgcc actatagttg gtactataac catatacaaa
     5281 gtttgtaaca atgcatttgg aaatagtgtt gttaaaaagt caattaaact attcatttat
     5341 catttcctcc catcttatgc ccttactagt tagatattgt tttacttgct ctccactttt
     5401 atctgaaatg tttataataa gtgaacctaa aatatcatct ttaaattgtt ctaatttccc
     5461 aaatattata gacacatcta tatttagttc tcttgccata gtcgtaataa tagcttcatt
     5521 agaaatatct ttagggaata gtatctttat atttgttcct tttggcaata ttatactttc
     5581 ttcacctatt aattttctaa gtcctttagt atttcttaag aatatttctt ctgtatctcc
     5641 tacctctaat acttctccat tttccattat tgctactctt ccacaaatct gctttataac
     5701 ttccatttga tgagttacaa ctattattgt tattcccaat tttttattta tatcttcaag
     5761 caatgaaaga attgactttg tagtatttgg gtctaatgct gaagtcgctt catcacaaag
     5821 aagtacttgt ggatttagtg ctaaagctct agcaattgca accctttgtt tttgtccgcc
     5881 acttagattt ctgggtttat catttttctt ttcagatatt ccaactactt ctaataactc
     5941 taaaactctt tttttaattt ctgcctttga gtatccaaaa cattctaatg gcaatgctac
     6001 attatcaaat acagtttttc tttcaagcaa tgaaaagtgt tgaaaaatca ttcctaactc
     6061 ttttcttaaa tctctcattt gcttttcatt caatgacttt acttctttat cagaaacaag
     6121 tacactgcct tcttggtatt cttctaatcc gtttatacat ctcagtagtg ttgatttccc
     6181 tgcaccacta tgacctatta ttccaaaaat ttctccagat tctatttcaa tacttacatc
     6241 tttaagcact tgaatctttc cataatactt attaacattt tttatgctaa tcataaaatt
     6301 tcctcccata tattctgctc agtttttatg tttatcctct cttatgtatt acaacaaaat
     6361 aaaagcccga gtataaactc aggcttagaa agctatttat actcatctat caactatatt
     6421 agttgcagga tttagcacca atgtatataa aatatactgg ttgccgggtt tcaaagggcc
     6481 agtccctcca ccactcttga taagacgtta tttaatttaa ttctattatc atttgttgct
     6541 atgttatata tgatatattc attaatagta tttgtcaata aatttattta aattttttat
     6601 tttttattat cgttaattaa ctatttttaa ttagttttct agctcctaac actttatatt
     6661 ttaatgtcta tataactata gaacatcatt ataagaaata aattaaataa catcaatcta
     6721 tctaaatcat ctgtaaagta aattaagaaa attaacattt tatccaaact ctatcctact
     6781 attaaataaa ataatttaaa tacaatgatg attatatagc tctagtactt tagactttat
     6841 caaatgttta agttctatag gttctattat tgtagcattt ttcccaaaag ttaaaaaata
     6901 ttcagccacc cagttaagtg tagattttgg tatatacata tctatgtatc cacctttaga
     6961 caagattttc aaccctcttg ccaacaaaaa ttctgtttca caacgtttta ctccctcatc
     7021 tgtcaaatta attttaatat gataatctgt acctacttcc atattcttaa gataatcatg
     7081 tatagaagat aaaaccttat atttcttact tgataagttt tctatactca aaatcttcac
     7141 aattctgtct acacgaaatt ccttaataga ttctgatttt atacagtaag ctggacaata
     7201 ccaaagtcca ttcatggcat acaaaccaat aggaacaatg gtacgtacac tatttttttg
     7261 ctttgatgaa tattcaattt taattgtaaa ttcattcatt actatattaa acaattcttt
     7321 caataatggt gttgaacagt gcctatctgg tgtccaaaaa acaaatttac gccttatatt
     7381 ctcaatatta tattgaatat catttggtat acaatttaaa aattttttta aaacagaaat
     7441 agtttcttgc tcaaatggca aatcattata atattctagt gactgatatg caaagaatat
     7501 agattttacc tcactttctg aaaatgcaat cggtggaagt atacgctctt taagtacatg
     7561 atatccacca gccgctccaa cttttgaata taatggaaat ccaatactct ccagcacctg
     7621 taaatctctt agtatagtac gttttgatac agaaaattct tctgctaatt ctcctgctgt
     7681 aaaacttctt tttgcattta ttgttatcat cagttcaatt aaacgctcag ctcttgacat
     7741 atttatactc ctaatttaaa tatagtgaca ataattgtca ctattatatg ataagatatt
     7801 cttgcatcta aagcaataat aatagtaaag aaagaaggga ttgatacttt atggaaaatg
     7861 atactattaa ggctgatgat attctcaatt attgtctatc aaacttagat gatgttgtac
     7921 taatggatag ttggggggaa cgagcaattt actacaatcc taatggtgtt ttaaagcgag
     7981 gggtatatgt tcttaccatt aaggaaaaag acagtaataa tgataaaggt tcgttagtta
     8041 gtcgtccaaa tgtataccgt gtgaatatag gattaaaaaa agaaactttt attgaaatgt
     8101 ttggatatat tccaaagcgt ccaggtgtag gtcaaatagt tgatatggat tttgatttta
     8161 caaaattgga cacaatcatg ccacatccta tctactcatg gatgggatgg atatgtgtcc
     8221 taagccctac tgaaaagaca tttgagaact ttaaaacttt aataggagaa tcttacaatt
     8281 ttgcaaaaca aaaatttaaa aagagaaaaa acaagtaaaa acgtgtgaaa ataacctcta
     8341 aataaattat aataaaaata ttaaggttac aagataaaaa ttaatatctt aataacatgc
     8401 aaaaaagcga agccaaaaaa tgtattattt ataaggcttc gctatatctc aaataattta
     8461 tttcaaattt caaaactatt tattctatta tttcttatta tttcctgtta ttcctaatct
     8521 atcattcata tcttttatca tttttctaaa accactacct atatcatttc caacatcttc
     8581 agttccatga actaatttta taaagtcatt ttgacctttt ttcatatctt catcagatac
     8641 cttatctaat ttttctattc tcttatctat atcttttact aatctttccc cttcagcgat
     8701 taggtcatca ttcattttct ttaactctgt atcttctgtt ttaccatctt ttttaagaga
     8761 tgttacaaat gattgtattt tatctctact atctttatat gcagccttta catcacttag
     8821 atatttttca tttcctggat attctttatc tttaaactga ttatttatac tttctggagt
     8881 atcataaata gaatatctat ttagacctgc tatataatca ttatagcttg ttgaataata
     8941 attcatatat ccttcattat tatttacaga ttcattagga ttttttcctg tattttcact
     9001 tggtttttca ttatttttag tacatgcagt tatacctata gctaatacta gtgctaatcc
     9061 taca
//
LOCUS       DAEHWM010000124         8855 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.127, whole genome shotgun sequence.
ACCESSION   DAEHWM010000124 DAEHWM010000000
VERSION     DAEHWM010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8855)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8855)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8855
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.127"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            184..951
                     /locus_tag="KNP36_003339"
     CDS             184..951
                     /locus_tag="KNP36_003339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YoaP domain-containing protein"
                     /protein_id="HBF0875185.1"
                     /translation="MQIIDININNIDNEHICCSISEKKGENCVFSKKAWMKNNFDKGL
                     VFKRFDVRGKAFIEYIPAENAWCPITADNYIFINCFWISGKFKGQGYSNLLLQECVDD
                     AKSKGKYGLVVLSSSKKMPFLSDAKYLKYKDFCLADTSEPNYELLYFPFTDNAPIPYF
                     KNCVKKRKLNENGIVLYYSNQCPHTEKYAPILKKIANSRGIDVNLIKFETAKEAQNAP
                     APFTTYSLFFNGEFVTNEILSEKKIEKFLDTNIKKFN"
     misc_binding    1169..1382
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            1636..2670
                     /locus_tag="KNP36_003340"
     CDS             1636..2670
                     /locus_tag="KNP36_003340"
                     /EC_number="1.2.1.38"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="HBF0875186.1"
                     /translation="MNKIKVGIIGATGYVGAELIRLLMNHDKVEVTAIGSNSYVGKDI
                     VDIYPSIGYKNNMICIENEKVIDMCDVVFTALPHGVSEKFVIKAIKSKKKVIDLGADF
                     RIKDEEVYSKWYGVSFIDKILHKKAVYGLSEIYKEDIKDADIIANPGCYPTSISLPLM
                     PLLSSKLIKNNNIIIDSKSGLTGAGRELSISSHFTEVNENITAYKIGKHRHTPEIEQN
                     LSESCKEKVSVVFTPNLIPVNRGILSTIYCTKEDNISINDIHRKLTDYYEFKEFIEIL
                     PLDKVASLKNVRFSNKCVISLHENGDTLIICSAIDNMIKGAAGQAIQNMNIIFGIEEN
                     TGLKNIAPSF"
     gene            2711..3928
                     /gene="argJ"
                     /locus_tag="KNP36_003341"
     CDS             2711..3928
                     /gene="argJ"
                     /locus_tag="KNP36_003341"
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="HBF0875187.1"
                     /translation="MEIIKGGVTVSEGFFASGIHCGLRKNKEKRDLALVYSDVLCDAA
                     AVVTQNKVKGNPVYVTQEHIKNGKAQAIIVNSANANTFNGKEGLINAYKMAKFTSDKL
                     NIKESDVLVASTGVIGKPLNIDLIEENMDELVNNLSKQGHIGAREAIMTTDIIKKEIA
                     VAIMYGDKKITIGGMAKGSGMIHPNMATTLGFITTDANIDGVLLKEALKIAVDKSFNR
                     VSVDGDTSTNDMVMILANGKAKNDRINKKDEHYQVFLSALTYVCIELAKLVAKDGEGC
                     TKLIECYINGALSEEHAVKLAKTVISSSLVKTAVFGADANWGRILCALGYAGEEIDME
                     KVDIIFESMKGYIEVCKNGNGLDFNEEKAKKILEDDEISILVDLNMGNARGNAWGCDL
                     SYDYVRINGSYRN"
     gene            3943..4803
                     /gene="argB"
                     /locus_tag="KNP36_003342"
     CDS             3943..4803
                     /gene="argB"
                     /locus_tag="KNP36_003342"
                     /EC_number="2.7.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetylglutamate kinase"
                     /protein_id="HBF0875188.1"
                     /translation="MINIEKANTLIEALPYIEKHQGKTIVVKYGGSAMKKDGLKESVM
                     EDLVLMSYVGINIVLVHGGGAEINKMLAKVDIESKFVNGLRYTDEETMEIVKMVLAGK
                     VNKDLVNKIHTKGGKAVGLCGIDNNMILCDPYKNYELGFVGEIKKVNVELIESCLKSG
                     YISVIATIGVGDDGETYNINGDTAASAIAKELNADKLILLTDVPGLLREPDEEKSLIT
                     EVILEDVDKLFEEGIITGGMIPKIEGCVDALNNGVNRVHILDGRVPHSIITELFTDSG
                     IGTLIRKETE"
     gene            4833..6020
                     /locus_tag="KNP36_003343"
     CDS             4833..6020
                     /locus_tag="KNP36_003343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate aminotransferase family protein"
                     /protein_id="HBF0875189.1"
                     /translation="MNNDNTISKWNEYFIDTYNQPNFVIDYGEGSCFFDTNGNKYIDF
                     TSGYGVSSLGYSNSNLKNALKEQVDKLLHTSNLYFNEPVLYSGEKIINSSGMAKVYFC
                     NSGTEANETAFKIARKYSSDKYGNGRGTIISLKDSFHGRTMMSLMATGMDKYHKYFYP
                     LPEGFKYIERNNIEDLKNNLDSTVCAIILEAIQGEGGVNVLEKDYVLEIVKICQEKDI
                     VVIFDEVQCGIGRTGKLFGYEYFDVKPDIVTVAKGLGAGIPVGGVLVNKKLSKVLGKG
                     DQGTTFGGNLLAMVAASVVLDEISKDGFYNEVLEKGNYIRKSIESFNNKVILKTKGIG
                     LMIGIETNIESSIIEEKARKKGLLILTAGKNVLRFLPPLTISYKEIDEALEILKDILL
                     EIN"
     gene            6129..7151
                     /gene="argF"
                     /locus_tag="KNP36_003344"
     CDS             6129..7151
                     /gene="argF"
                     /locus_tag="KNP36_003344"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HBF0875190.1"
                     /translation="MNNISLKGKSFLTLKDFTKEEIRYLLTLSSYLKTKKKVGIKGDL
                     LQGKNIALLFEKTSTRTRCSFEVAAHDEGAHVTYLGPNDCHMGKKESVSDTAKVLGRF
                     YDGIEFRGFKQETVESLAKYSGVPVWNGLTDEYHPTQILADFLTVIENVDKDLNKVKF
                     VYVGDARNNMGNSLMIGCAKMGIHFVALAPKELWPNEELVKEMKEIAKKSKGDIMLTE
                     NIDDVKGADVIYTDVWVSMGEEEQYEARINQLKDYQVNMDMIKKTENENVIFLHCLPA
                     FHDLETKVAQEIYEKFGLSELEVTNEVFNSKYSKVFEEAENRMHTIKAVMVSTMTDVN
                     MNNNLI"
     gene            7278..7895
                     /locus_tag="KNP36_003345"
     CDS             7278..7895
                     /locus_tag="KNP36_003345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4878 domain-containing protein"
                     /protein_id="HBF0875191.1"
                     /translation="MKKIILALTTFLLAISLTACSSAKPEDTIDSFFNSAKKFDFEGM
                     NKVMENNDEKYKDILKELDTKDPNAQYVLDYLKQNASKITYTIKDSEVKGDKATIKVE
                     CKFIDSTPLLQEIVAEAFTKMIGMSFSGQDLTDEKTTEMLVSIMKEKQKSVKETYVTK
                     NVEFECSKKDNKWIISSVNDAVADVLLSNLVTAGQEFSNSMNTLE"
     gene            complement(8115..8813)
                     /locus_tag="KNP36_003346"
     CDS             complement(8115..8813)
                     /locus_tag="KNP36_003346"
                     /EC_number="5.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid racemase"
                     /protein_id="HBF0875192.1"
                     /translation="MNEKLIGILAGMGPRSTAPFVDLIIDECQSQYGAKYDDEFPKMM
                     IYSLPTPFYIDRPINHDLMKETIIDGLQKLESTGVNFIAMPCNSAHIYFKELKESINI
                     PILNIVEETVKKLPTISQKVTLFSTSSTFESTIYQNGIIHNGHEFIFKDEWQIKLNNL
                     IQNIKMDKENPHNIDIWNKLIEDVKNESIENIVIACTDLNVVLEKSYPSINIVDSSKC
                     LAESVVNKYLKLVK"
BASE COUNT         3563 a          860 c         1588 g         2844 t
ORIGIN      
        1 tagtgtagtt agaccataga atgtatttaa ttatatatac aatttaataa ttcagataat
       61 cttaaaataa tattatgtaa aataaaaata tatatgacat gatgttgttg tattcaaaat
      121 attaagataa aaatatatag aatatattta aaaattatta tgcaattaga aaaggagata
      181 agtatgcaga ttattgatat aaatataaat aatattgaca atgaacatat atgttgttca
      241 atttctgaaa aaaaaggaga aaattgtgtt ttttctaaaa aagcttggat gaaaaataat
      301 tttgataaag gtctagtctt taaacgattt gatgtaagag gtaaagcttt tatagaatat
      361 attccagcag aaaatgcatg gtgtcctatt actgcggaca attatatatt tattaactgt
      421 ttttggatat ctggaaaatt taagggtcaa ggatattcta atctattgct acaagagtgt
      481 gttgatgatg caaaatcaaa aggtaaatat ggattagttg tgctttcgtc tagtaaaaaa
      541 atgccttttt tatctgatgc taaatatcta aaatataagg acttttgttt agcagataca
      601 tcagaaccaa attatgagct attatatttt ccttttactg ataatgctcc tattccatat
      661 tttaagaatt gtgtaaaaaa aagaaaatta aatgagaacg gtatagtttt atattacagt
      721 aatcagtgtc cacatacgga aaaatatgct cctattttga aaaaaattgc aaattctaga
      781 ggtattgatg taaatcttat aaaattcgaa acagcaaaag aagcacaaaa tgctcctgca
      841 ccatttacta catacagtct tttttttaat ggtgaatttg taaccaacga gatactttct
      901 gagaaaaaga ttgagaaatt tttagatacc aacattaaaa aatttaacta aaaagagatg
      961 taaatattgt attttgaaaa tatattattt tataatttaa tatattttgg atgtttttta
     1021 aattgacgaa tgaaatataa aaattatatc gcaatttaga tacaaaatgc tggaaattaa
     1081 ccatatagaa aatatttcca aaaatttaaa aattatattg acaaagttaa aaaaataaac
     1141 tatcatataa aacaataaga aaataaattg aaatcctgtg aaaaagagag tagcataaag
     1201 ctagttgata gagagctggg aatggtggaa gcctagtaac gaattttatt gtgaatagag
     1261 ctttggagga gattaccaga agtaatagta tggtaattgg tgaatctcgc cttaagagat
     1321 tagagtgggt aagattatct tatcaattag agtggtaacg cgggtgtata ttcgtctctt
     1381 ggtctttgac caagaggctt ttttaatttt aaatgtacat tttgtagata ctttttaatt
     1441 tgagttttaa tgattattgt aattttacca ataagagtgg taccgcggaa aatcgcctct
     1501 tagtatttat aatgctaagg ggttttttgt tttaattaga gtattttaat ctacgtatta
     1561 tcaaatgatt atcatatagt aaagtggaaa gataggattt taagactatt tgaatataaa
     1621 aatggaggga acaaaatgaa taaaataaaa gttggtatta ttggtgcaac tggatatgtc
     1681 ggggcagagt tgattagatt attaatgaat catgataaag tcgaagtgac agcgataggt
     1741 tcaaattcgt atgttggaaa agatatagtt gatatatatc caagtatagg atataaaaat
     1801 aacatgatat gtatagaaaa tgaaaaagtt atagatatgt gtgatgttgt atttacagcc
     1861 cttccacatg gagttagtga aaagtttgta ataaaggcaa ttaaatcgaa aaagaaagtt
     1921 atagatttag gtgctgactt tagaataaaa gatgaagaag tatatagtaa atggtatgga
     1981 gtatctttta tagataaaat cttacataaa aaagctgtat atggattaag tgaaatatac
     2041 aaagaagata taaaagatgc agatataatt gcaaatcctg gatgttatcc aactagtatt
     2101 tctttaccat tgatgccatt actaagttct aaattgataa aaaataataa tataataatt
     2161 gattctaaat caggtcttac aggtgctggt agagaattat cgattagtag tcactttacg
     2221 gaggttaatg aaaatatcac tgcatataaa atagggaagc acagacatac tccagaaata
     2281 gaacaaaatt taagtgaatc ctgcaaagaa aaagtaagtg tagtttttac accaaactta
     2341 atcccagtaa ataggggaat cttatcaact atatattgta caaaagaaga taatatttct
     2401 ataaatgata tacataggaa attaactgat tattatgaat ttaaagaatt tatagaaatt
     2461 cttccattag ataaggtagc ttctttaaag aatgttagat tctcaaataa atgtgtaata
     2521 tcattacatg aaaatggaga tacattgata atctgttcag ctatagataa tatgattaag
     2581 ggagcagcag gtcaagctat acaaaacatg aatataatat ttggtattga agaaaataca
     2641 ggtttaaaaa atattgcacc atcattttag aaataaaaaa tactaaactc atataattag
     2701 gaggataaat atggagatta taaagggtgg agttacagtt tcagaaggat tttttgcttc
     2761 agggattcac tgtggcttga gaaaaaataa agaaaaaaga gatttagctt tggtttattc
     2821 agatgtttta tgtgatgcag cagcagtagt aactcaaaat aaagtaaagg gcaatcctgt
     2881 ttatgttaca caggaacaca ttaaaaatgg aaaagcacaa gctatcatag taaatagtgc
     2941 taatgctaat acctttaatg gaaaagaagg acttataaat gcttataaaa tggctaaatt
     3001 caccagtgat aaattaaata ttaaagaaag tgatgttttg gttgcatcta caggtgttat
     3061 aggaaagcca ttaaatatag atttaataga agaaaatatg gatgaattag tgaataatct
     3121 aagtaaacaa ggtcatattg gagcaagaga agctattatg acaactgata ttataaaaaa
     3181 agaaatagca gtagcaataa tgtatggaga taaaaaaata actattggag gtatggcaaa
     3241 aggttctggc atgatacatc ctaatatggc aacaacgtta ggatttataa ctacagatgc
     3301 aaatattgat ggagttttgc taaaagaagc tttaaaaatt gctgttgaca aaagttttaa
     3361 tagagttagt gtagatggag atacaagtac taatgatatg gtaatgattc tagcaaatgg
     3421 aaaagcaaaa aatgatagaa taaacaaaaa agatgaacat tatcaagtat ttttgagtgc
     3481 acttacatat gtctgtatag aacttgctaa acttgttgca aaagatggag aaggatgtac
     3541 aaaactaatt gaatgctata taaatggagc attaagtgaa gaacatgcag taaaattagc
     3601 aaaaacagtt atatcttctt cattagtaaa gacagctgta tttggagctg acgcaaattg
     3661 gggtagaata ctgtgtgctt taggttatgc aggtgaagaa atagatatgg aaaaagttga
     3721 tattattttt gagagtatga aaggatatat tgaagtatgt aaaaatggaa atggattaga
     3781 ttttaatgag gaaaaagcaa aaaaaatcct tgaagatgac gaaataagta tattagtaga
     3841 tttaaatatg ggcaatgcca gaggaaatgc atggggatgt gatttaagct atgattatgt
     3901 aagaataaat ggaagttata gaaattagga ggatatactt taatgattaa tatagaaaaa
     3961 gcaaatacac ttatagaagc tttaccatat atagaaaaac atcagggaaa gactattgta
     4021 gttaagtatg gtggaagtgc aatgaaaaaa gatggtctaa aagaatctgt tatggaagac
     4081 cttgtgttaa tgagttatgt tggaatcaat atagttttag tacatggtgg aggggcagaa
     4141 atcaataaga tgctagcaaa agtggatata gaaagtaaat ttgtaaatgg tcttagatat
     4201 acagatgaag agaccatgga aattgtaaaa atggtacttg ctggaaaggt taataaagac
     4261 ttagtaaata aaatacatac aaaaggtgga aaagcagtag ggctttgtgg aatagataat
     4321 aatatgattt tatgtgaccc atataaaaat tatgaacttg gatttgtagg agaaatcaaa
     4381 aaagtaaatg ttgagcttat agaatcttgt ctaaagtcag gttatatttc agtaattgca
     4441 actataggtg ttggagatga tggagagact tataatataa atggtgacac agcagcttct
     4501 gctatagcta aagagttaaa tgcagataaa ttgatacttc ttacagatgt ccctggtttg
     4561 ttaagagagc cagatgaaga aaaatcatta ataacagaag ttatattaga ggatgttgat
     4621 aaattatttg aagaaggtat aattactgga ggtatgatac ctaaaataga gggatgcgta
     4681 gatgccttaa ataacggagt aaatagggta catattttgg atggaagagt tccacattct
     4741 ataataacag agctatttac tgatagtgga ataggtacat taataagaaa agaaactgaa
     4801 taaaattata agtttaagag gggagaataa gaatgaataa cgacaataca atttcaaaat
     4861 ggaatgaata ttttatagat acatataacc aacccaattt tgtcatagat tatggtgaag
     4921 gaagttgttt ttttgatact aatggcaata aatatataga ttttacaagt ggatatggag
     4981 tatcttctct tgggtatagt aatagtaatt taaagaatgc tctaaaagag caagtagata
     5041 aattattaca tacttcaaat ttatatttta atgagccagt gttgtattca ggagagaaaa
     5101 taattaattc aagtggaatg gctaaagtat atttttgtaa ttctggaaca gaagcaaatg
     5161 aaacagcatt caaaatagca agaaagtata gtagtgacaa atatggtaat ggtagaggaa
     5221 ctatcataag tttaaaagac tcttttcatg gtagaacaat gatgtcttta atggcaactg
     5281 gtatggacaa ataccataag tatttttatc ctcttcccga aggttttaaa tatatagaaa
     5341 gaaataatat tgaagattta aaaaataatc ttgattccac agtttgtgca ataattcttg
     5401 aagcgattca aggcgaaggt ggagttaatg ttcttgaaaa agattatgtt ttggaaatag
     5461 taaaaatatg tcaagaaaag gatattgtag tgatttttga tgaagtccaa tgcggtatag
     5521 gaagaactgg taaacttttt ggctatgaat attttgatgt aaaaccagat atagttaccg
     5581 tagcaaaagg gttgggagca ggaataccag taggaggagt attggtaaat aaaaaacttt
     5641 caaaagtact aggaaaagga gaccaaggta caacttttgg aggtaattta ttagctatgg
     5701 tggcagcttc agttgtatta gatgagatat ctaaagatgg cttttataat gaagtattag
     5761 aaaaaggaaa ttatataaga aaatctattg aaagttttaa taacaaagtt atattaaaga
     5821 caaaaggtat tggtctaatg ataggaattg aaactaatat tgaatctagt attatagaag
     5881 agaaagctag aaaaaaagga ttgcttattt tgactgctgg aaaaaatgta ttgagatttt
     5941 taccaccatt aacaatcagt tataaggaaa tagatgaggc tcttgaaatc ctaaaagata
     6001 tattactaga aattaactaa atattcaaaa aatagttgat taaagataaa aattagaagt
     6061 aaataaaaaa gtaaagtgct aacaagttta attgaattta aaaagtttat aagaaggggc
     6121 gaattaatat gaataatata agtttaaaag gtaagagttt tttgacatta aaggatttta
     6181 caaaagaaga gattagatat ttattaactt tatcaagtta tttaaaaact aagaaaaaag
     6241 ttggtataaa aggcgatttg ctacaaggaa aaaatatagc tttattattt gagaaaacat
     6301 caacaagaac tagatgttca tttgaagtag cagctcatga tgaaggagca catgtaactt
     6361 atctaggtcc aaatgattgt catatgggta aaaaagagtc tgtatcagat acagcaaaag
     6421 ttctaggaag attctatgat ggaatagaat ttagaggctt taaacaagaa acagttgaaa
     6481 gtctagcaaa atattctggt gtacctgttt ggaatggact tacagatgaa tatcatccaa
     6541 cacaaatact ggcagatttt ttaacagtaa ttgaaaatgt agataaagat ttgaataaag
     6601 ttaaatttgt atatgttggt gatgctagaa ataatatggg gaactcactg atgataggat
     6661 gtgctaaaat gggaatacat ttcgtagcac tagcacctaa ggaactttgg ccaaatgaag
     6721 aattggttaa ggaaatgaag gaaatagcca agaaatccaa aggagatata atgttgactg
     6781 aaaatattga tgatgttaaa ggtgcagatg ttatatatac agatgtatgg gtttctatgg
     6841 gagaagagga gcaatatgaa gcaagaataa atcaacttaa agattatcaa gtaaatatgg
     6901 atatgataaa gaaaactgaa aatgaaaatg ttatattttt acactgtctt ccagcatttc
     6961 atgatttaga aactaaggtt gctcaggaga tttatgaaaa gttcggatta tcagaattag
     7021 aggttacaaa cgaggtattt aattcaaaat attcaaaggt atttgaagaa gctgaaaata
     7081 gaatgcatac aataaaagct gttatggttt ctactatgac tgatgtaaat atgaacaata
     7141 atttaatata gatatgtttt aatatagact ttactttaat gaaaatttat aaaatatttt
     7201 aaatatatta ttcaaaaact ctcattatat gttaaaataa cttatgtatc aacaaattaa
     7261 gagggaggat ttgagatatg aaaaaaatca tattagcttt aacaactttt ttattagcaa
     7321 tatctttaac agcatgttca agtgcaaaac cagaagatac aattgatagt ttttttaaca
     7381 gtgcgaaaaa gtttgacttt gaaggcatga ataaggtaat ggaaaataat gacgaaaaat
     7441 ataaggatat attaaaggaa ttagatacaa aagacccaaa tgcccaatat gttttagatt
     7501 atctaaaaca gaatgcatct aaaatcacat atacaataaa agacagcgag gttaaaggtg
     7561 ataaggctac aatcaaagta gaatgtaaat ttatagattc aacaccatta cttcaagaaa
     7621 tagtagctga ggcatttaca aagatgattg gtatgagttt ttcaggacaa gacttaactg
     7681 atgagaaaac aactgaaatg ttagtatcaa ttatgaaaga aaaacaaaaa agcgttaaag
     7741 agacttatgt tacaaaaaat gtagagtttg aatgttctaa aaaggataat aaatggataa
     7801 taagttcagt aaatgatgca gtagctgatg tattgttatc taatcttgtt acagcaggac
     7861 aagaattttc taactctatg aatacacttg aataatattg tttaggtgta gtaaagtaat
     7921 aaatatatga ttatttttat aaataaacat ataaatattt atgaaggata ccatttttgg
     7981 tatccttttt attaatataa tgaaatacat ggttaatttc tatattgtca agaaactatg
     8041 atatatgtta taagtctata ctatttaaaa taaacttata acatatattt tttataatat
     8101 agtgtatgaa aaatttattt aactaatttt agatatttat tgacaactga ttcagccaag
     8161 cattttgatg aatcaacaat atttattgaa ggatatgatt tttctaaaac tacatttaaa
     8221 tcagtacaag caattactat attttctata gattcatttt taacatcttc aataagttta
     8281 ttccaaatat caatattgtg tggattttct ttatccattt ttatattttg aataagattg
     8341 tttaatttta tttgccattc atctttaaat ataaattcat gtccattatg tattatacca
     8401 ttctggtaaa ttgtagactc aaaagttgaa ctagtcgaaa aaagagttac tttttgtgag
     8461 atagtaggta attttttaac tgtttcttct acaatattta atattggtat attaatagac
     8521 tcttttaatt ctttaaagta tatatgtgct gaattgcatg gcattgcaat aaaatttaca
     8581 ccagttgatt caagcttttg taatccatca attatagttt ctttcataag gtcatgattt
     8641 attggacggt caatataaaa tggggtaggt aatgaatata tcatcatctt tggaaattca
     8701 tcatcatatt ttgctccata ttgagattga cactcatcaa taattaaatc aacaaaaggg
     8761 gctgttgacc ttggacccat tccagccaaa ataccaatta atttttcatt cataaaaatt
     8821 atctccttta tatataaata tatttatgta taaaa
//
LOCUS       DAEHWM010000125         8764 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.128, whole genome shotgun sequence.
ACCESSION   DAEHWM010000125 DAEHWM010000000
VERSION     DAEHWM010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8764)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8764)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8764
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.128"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            59..505
                     /locus_tag="KNP36_003347"
     CDS             59..505
                     /locus_tag="KNP36_003347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HBF0875193.1"
                     /translation="MDFKNLQYESLSYIICNLQKNFKLYCEKCLKPYKLTNGLYFYLI
                     YINKNRNCSLNDVSTEFEVDKAHTTRTISRLEQDGYIEKIQNPNDSRAFQLRVTDKGE
                     EVLGDIKNIFSKWDNHIKKEFSDTEYKELVKNLHVVKDIKTAVEEE"
     gene            507..1601
                     /locus_tag="KNP36_003348"
     CDS             507..1601
                     /locus_tag="KNP36_003348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="HBF0875194.1"
                     /translation="MYCNLLKPIKIGNLELKNRVSFAPTSMGLKLEEKIKKFSDIAKS
                     GVALITLGDVSIRPSFHKVAISLSDEDGVMKYKKIVDEIHNSGAKVSAQLFCSDYDVN
                     LIKDTMNMGITSHDEIKKIMNDGVKDYITNMPKEEIKNIINLFKVTALNAKKAGFDMI
                     QIHGDRLVGSFSSSIFNNRNDEYGRTCDNRSRFASEIISSIRDEVKDIPIDYKFAIRQ
                     ENPHYGNAGVLLSEVEYFVKKFESLGVNSFHVTLANHSKLEDTIPTNNHPYFKEEGCF
                     LYLADEVKKHTNLPVCGVGKLSSPDFIESIISNNRVDMVSMSRQLLADSNWLQKVKDG
                     RVDEIKKCCYCNKKCADALQTRSQFGCILD"
     gene            1689..2219
                     /locus_tag="KNP36_003349"
     CDS             1689..2219
                     /locus_tag="KNP36_003349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0875195.1"
                     /translation="MKSLVLYSSLTGNTKKIAYTIYDEIQEEKDIKDVNELVDYGIDY
                     ENYDIVFLGYWVDKGICDKNSKQVLENIHNKKIALFGTMGASKKGSYGASIIEKIESI
                     IPKDNEILGSFICQGKIAEGLKAKYKEMLKLSPDNEHIRQQLNNHEESQSHPDEQEIY
                     EASMFAKNMMIKASIV"
     gene            complement(3155..4531)
                     /locus_tag="KNP36_003350"
     CDS             complement(3155..4531)
                     /locus_tag="KNP36_003350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875196.1"
                     /translation="MKYKIGFLTTSYFMSDKFKQALKELNDTCEITFIELKGENPFNN
                     LPNIYYEQVDNFDGFVCSGIVPYSELIINIKDIKVPLNFLKLDEKDFYKYLFKLLNSQ
                     KDIDFTKSFMDFLREDNNYYDIYSLIDSNKCPYTIKDFNIPQPVYDFKKLNDKLLEIH
                     LDLLRDNKINLSFTRNYIISCELNKLGYDSIYMVPSTESILNTFKSLVNEITLQNLDK
                     NKSATCIVTVNSSEYINEDLIFKNDEIQNQIYNTILNSLSRHGFYGVQVKKNDMKIEI
                     HTTKEMLNNMTNNYTDFFISEDLKEIKYSLNIGWGIGNTNIHAEQNARQANGKSASLN
                     GNCTFIVNDTNDTIGPLYSNKNSNNIEDSSIANKVASFIPLSNTNVSKIMCMINDRNS
                     NNVSAEILADYMNITLRSANRILSILYKAGIATIVNTKLDNQRGRPKKIYKVDFLSFL
                     NKMQKLNS"
     gene            4799..5971
                     /locus_tag="KNP36_003351"
     CDS             4799..5971
                     /locus_tag="KNP36_003351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HBF0875197.1"
                     /translation="MNTYLNEISKFVDENREEIVSLWKEIVNMESYTHCKESVNKLAK
                     RLKFEFEKEGLDCELVDVGDNGSTLIGTLGSNIDKKPIIFSGHMDTVFETGTFGENPF
                     KIIEGKAYGPGVLDMKGGIIISLYAIKALNKIGYKERPIKIVFSGDEEIGHKDSTGAD
                     VILREAKGGLCAFNMETGLVDNSLCVGRKGRIGCNIHVKGVETHAGNDFEGGRNAIEE
                     MANKILRIQKLTNLDVGTTVSVSVIKGGRVENSIPEDCSIKVDLRFEKVEEMENVKEQ
                     VREICKETYIEGTSTEVNFISEMMPFETTEDVMRFHTFVNEVSKENGFGELNAKRLGG
                     SSDASYLTIANVPTICSFGVRGEWNHTSREYAVVDSMFERVKLISTVILNLDKFEV"
     gene            5985..6632
                     /locus_tag="KNP36_003352"
     CDS             5985..6632
                     /locus_tag="KNP36_003352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003431751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875198.1"
                     /translation="MDVTAGDNKVTWKGYLSLFVLIVLFSGVFKDSQGFLKALDFANL
                     TGSFGTIADGVDFMGKGGTGAKDGFLFALTLIPTVCFAVGLIDVVESMGGMKAASKIF
                     NPLLRPLLGIPGIAGIAFVSSFTSSDVASIMTKELFESGEITDDERTIFVAYQYAGSA
                     VILNTINTQAPLLPIALLALGPIILIEIFCKILGANLVRLIIGVRNKKNKAKEAV"
     gene            6634..7143
                     /locus_tag="KNP36_003353"
     CDS             6634..7143
                     /locus_tag="KNP36_003353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjiG family protein"
                     /protein_id="HBF0875199.1"
                     /translation="MSQQNTGNVIVNSKPKKTAVEIFMGGAKKGFYIGVEQILPAMIM
                     GYVIVQFLQLTGLVDILGNIFGPVMGIFGLPGESVVVLIAAFFAKAAGAATAANLFAQ
                     GLITAPQATILIMPCMLMGTLVGHYARIVLVANASTKYRMLLLAVPIFDAIVGMLIVR
                     VLLTVMGLM"
     gene            complement(7507..8619)
                     /locus_tag="KNP36_003354"
     CDS             complement(7507..8619)
                     /locus_tag="KNP36_003354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003422798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HBF0875200.1"
                     /translation="MKISEVATPNFLLDLDQLEKNIDKIQQICTNNNKQLWPMLKTHK
                     STYIARLQKNAGASGFLVGTLDEGEALIKAGFEDIMLAYPYMGEVNINRIVTMASKIN
                     LICATDNIECAKAYSEAFSKSKIECKLLIIVDCGLHRFGVEPEKVVELATEISKLENI
                     KIVGISSHPGQVYGCSSPEGVPDVCVQEDSSMEKAYKALTDNGFNIEIVASGSTPTVE
                     SEAASKTITAVRPGNYVYYDAIQIGLGCATEDMCALTVVCTVISKNSSGYYLIDCGSK
                     CLGLDKGAHGNSSIVGYGRVCGHPELTIDSLSEEVGKIKVNGETDIKIGDRIRIIPNH
                     SCSTANLTSNLLGFRGDTIEKVIEVDIRENSKQIIL"
BASE COUNT         3265 a         1017 c         1440 g         3042 t
ORIGIN      
        1 ttaatataat atagttgata tagtcaaaca tattataatt atagaaggga aatttaagat
       61 ggattttaaa aatttacagt atgaaagttt gtcatatatt atttgtaact tgcaaaaaaa
      121 ctttaaactt tattgtgaaa aatgtttaaa accatataaa cttacgaatg gtctatattt
      181 ctatttaatt tatattaata aaaataggaa ttgttctttg aatgatgttt ctacagaatt
      241 tgaagttgat aaagctcata caacaagaac tatatctagg ttagaacaag atggatacat
      301 agaaaaaatc caaaacccta atgatagtag agcttttcag ttgagagtaa cagataaggg
      361 tgaggaagta ttaggggata taaaaaacat attttcaaag tgggataatc acataaaaaa
      421 agagttctcg gatacagaat ataaagaact ggtaaagaat ttacatgtgg taaaggatat
      481 aaaaacagct gtggaggaag aataggatgt attgtaattt attaaaacca attaaaattg
      541 gaaatttgga attaaaaaat agagtatctt ttgcacctac aagcatgggt cttaaattgg
      601 aagaaaaaat taaaaagttt tctgatattg ctaagtcagg agtagctctg attactctag
      661 gagatgtatc tattagacct agttttcata aggtagctat aagcctatcg gatgaagatg
      721 gagtcatgaa atacaagaaa attgtagatg aaatacacaa ttctggtgca aaggtatcag
      781 cacaactatt ttgttcagat tatgatgtta atttaattaa agatactatg aatatgggaa
      841 ttacttcaca tgatgagata aaaaaaataa tgaatgacgg agtaaaagat tacataacaa
      901 atatgcccaa agaagaaatt aaaaatatta taaatttatt taaagtaaca gcattgaatg
      961 caaaaaaagc aggttttgac atgattcaaa ttcatggtga taggcttgta ggaagttttt
     1021 catcaagtat atttaataat agaaatgatg aatatggtag aacgtgtgat aatagaagta
     1081 gatttgcaag cgaaataatt agtagtatcc gagatgaagt taaggacatt ccaatagact
     1141 ataaatttgc aataagacaa gaaaatcctc attatggaaa tgcaggagtt ttactttcgg
     1201 aagttgagta ttttgttaaa aaatttgaat ccctaggtgt aaacagtttt catgtaacac
     1261 ttgcaaatca ttcaaaatta gaagatacta taccaaccaa taatcatcct tactttaaag
     1321 aagaaggctg ttttttatat ttagctgatg aagtaaagaa acacacaaat cttccagtat
     1381 gtggggttgg aaaattgtct agcccagatt ttatagaaag tattatttca aataatagag
     1441 tagatatggt ttctatgtca agacaattac tagcagatag taattggtta cagaaagtaa
     1501 aagatggaag agtagatgag attaaaaagt gctgttattg taataagaag tgtgcagatg
     1561 ctttacaaac acgctctcag tttggatgta tactagatta gaatatcctt ataaaaataa
     1621 ataatttgtt aaggttaata tatttttggt gatttagata aatatttaga taaagaggag
     1681 gagacatcat gaaaagttta gttttatatt caagtttaac tggaaatact aaaaagattg
     1741 cttatactat atatgatgaa attcaagaag aaaaagacat taaagatgta aatgaattag
     1801 ttgattatgg tattgactat gaaaattatg atatagtatt cttaggctat tgggtggaca
     1861 agggaatttg tgataaaaat tcaaaacaag tgcttgaaaa tattcacaat aaaaagatag
     1921 cactatttgg aacaatggga gcaagtaaaa aaggaagtta tggagctagt ataatagaaa
     1981 agatagaatc aattatccca aaagataatg aaatactagg ttcattcata tgtcaaggta
     2041 agatagcaga aggattgaaa gcaaaatata aagagatgtt aaaactttct cctgacaacg
     2101 aacatattcg ccaacaatta aataaccatg aggaatctca aagtcatcca gatgaacaag
     2161 aaatatatga agccagtatg tttgcaaaaa atatgatgat taaagctagt attgtgtagt
     2221 agttaaacaa taagttcata taagatatag aataaataat ttagtaaaaa agtatagcaa
     2281 ataatttgct atgctttttt tatgaaatca aaaaaataat aaaaatactt gactgtaaac
     2341 cttgtttata cattatttta tagaaaataa gatagtttta aatataaaaa aagatatatt
     2401 attgaaagga gatattattg tatgaaaact tataaaagat aattagtttg attttaagat
     2461 atactaaata tacaatttta tagagtgaaa atatttaaga ctatattata gttataaatt
     2521 aatagaatag agaggtagtg tttaaattgc aataacagta tttcaaaagt tgccacctca
     2581 aattcctatc caatggaata atggtgtagc taattatgta gataaaaaat ttatttatgc
     2641 ctaccctgtc atttgtgttg tattcagaat acttttacgt ccatttatat ggagatggtt
     2701 acaaatacat gctttttata gtgatactat tgcagattat ttaacgaatt ttatgtgttt
     2761 tgtagcgttg tctatagaaa tattctctat attttttatt tacaatattg tcagacatgt
     2821 tacaataatt atttttatag atatacttgt atttattgct ttactgataa taggtgtgta
     2881 taaattattt aaaaaataca attaattttt aaaaataagt aataagtgat agtgtaaaaa
     2941 gtagccactg caaattatgg attgtagtgg ctattttatt atttgtatat gaaattattt
     3001 tgtttttcta ataagttacg atatattatg gtttatttca ctgataaaag gtttaggtat
     3061 tttaaagtaa aaagttgtat attctaataa aatttaaaca ttttgattct ttaaaattag
     3121 agaaaataca ttgcttttat taaaaaatta aatattaaga atttaatttc tgcatcttat
     3181 ttagaaaaga taagaaatca actttatata ttttttttgg ccttcctctt tgattatcga
     3241 gttttgtatt tacaatagtt gcaattcctg ctttatataa gatactcaat attctattag
     3301 cacttctaag agttatgttc atatagtctg ctaatatttc tgctgacaca ttatttgaat
     3361 ttctatcatt aatcatacac atgattttag atacatttgt attagataga ggtataaaag
     3421 aagcaacttt attggctatt gagctatctt caatattatt agaattttta tttgaatata
     3481 aagggcctat tgtatcatta gtatcattta ctataaaagt acagtttcca ttcaaagaag
     3541 cagatttacc attagcttga cgagcatttt gctctgcatg aatatttgta tttccaatgc
     3601 cccaacctat atttaagcta tatttaattt cttttaaatc ttctgaaata aaaaaatctg
     3661 tatagttatt ggtcatattg tttaacattt ctttagtagt gtgtatctct attttcatat
     3721 catttttttt gacctgaact ccatagaatc catgtcttga tagagaattt aatatagtgt
     3781 tatatatttg attttgtatc tcatcatttt taaatatcaa atcttcattt atgtactctg
     3841 aactatttac tgtaactata caagttgcag atttattttt gtctaagttt tgtaatgtta
     3901 tttcattcac cagagattta aatgtattca ggattgattc tgtagatgga accatgtaaa
     3961 tagaatcata tccaagttta ttaagttcac aactaatgat gtaatttcta gtaaaagaaa
     4021 ggttaatctt attatctcgc aataagtcta aatgtatttc caataattta tcatttaatt
     4081 ttttaaagtc atatacaggt tgagggatat taaaatcttt aattgtatat ggacatttat
     4141 tagagtctat taatgaatat atatcataat aattgttgtc ctctcttaaa aaatccataa
     4201 atgattttgt aaagtcaata tctttttggc tatttaataa tttgaataag tatttataaa
     4261 aatctttttc atcaagcttt aaaaaattta atggaacttt tatgtctttt atatttatta
     4321 taagttcact atatggaact ataccactgc atacaaatcc atcaaaatta tctacttgct
     4381 catagtatat attaggtaaa ttattaaaag gattctcccc tttaagctca ataaatgtaa
     4441 tttcacaagt atcatttaat tctttaagag cttgtttaaa cttatctgac ataaaataag
     4501 atgttgtcaa aaaaccaatt ttatatttca taaaacctcc tttaaaattt cgagagtatt
     4561 gtaactaatc aatcaattta taacctcatt ttataatagt agataaaacg cgtcaattta
     4621 ttttacaaaa ggaaaattga aagaaaaatc agaaaatata aaaaagactg aaaaatatgt
     4681 tgactgtcaa gaataattgt gctattttgt aattaaggac tagtctttta agatttccta
     4741 aaataaactt agattttagg aaagaaatac attttatttg aaaataaagg agaagattat
     4801 gaatacatat ttaaatgaaa tttctaagtt tgttgatgag aatagagaag aaatagtttc
     4861 attatggaaa gagattgtta atatggaaag ctatacacat tgtaaagaaa gcgtaaataa
     4921 attggctaag agattaaagt ttgagtttga aaaagaaggt ttagattgcg agttagtaga
     4981 tgttggagat aatggtagta cattgatagg tacacttggt tccaatatag ataaaaagcc
     5041 aataattttt tcaggtcaca tggatactgt ctttgaaaca ggtacatttg gagagaatcc
     5101 atttaaaata atagaaggaa aagcatatgg cccaggtgtt ttagatatga agggtggtat
     5161 aataatttcc ttatatgcta ttaaagcatt aaataaaata ggatacaaag aaagaccaat
     5221 aaaaatagta ttttctggag atgaagagat aggacataag gattcaacag gtgcagatgt
     5281 tatattgagg gaagcaaaag gtggtctttg tgcttttaat atggaaactg gattagtaga
     5341 taatagtttg tgtgtaggta gaaaaggaag aataggatgt aatatacatg taaaaggtgt
     5401 agaaacacac gcaggtaatg attttgaagg tggaagaaat gctatagaag aaatggctaa
     5461 taagatacta cgcatacaaa aattgactaa tttagatgtt ggaactacag taagtgtaag
     5521 tgtgattaag ggtggaagag tggaaaattc tattccagaa gattgtagta taaaagtaga
     5581 ccttagattt gaaaaagtag aagaaatgga gaatgttaaa gaacaagtta gagagatatg
     5641 taaagaaact tacatagaag gaacttctac agaagttaat tttataagtg aaatgatgcc
     5701 atttgaaact acagaagatg ttatgagatt tcatacattt gtaaatgaag tgtcaaaaga
     5761 aaatggattt ggagaattaa atgctaagag acttggaggt agttcagatg caagttattt
     5821 aactattgca aacgttccta caatctgttc atttggtgta agaggagaat ggaaccacac
     5881 atcaagagaa tatgcagtag tagattctat gtttgagagg gtgaaattaa tttctacagt
     5941 tattttaaac ttagataaat ttgaggtata aagggggatt ttatatggat gtaacagctg
     6001 gagataataa ggtaacatgg aaagggtatt tatctttatt tgtattgata gtattatttt
     6061 caggagtgtt taaagatagt caaggcttcc ttaaagcatt agattttgct aatctgacag
     6121 gttcatttgg tactattgca gatggtgtag actttatggg taaaggagga acgggagcaa
     6181 aagatggttt cttatttgct ctgactttga ttccaactgt ctgttttgct gtaggtctta
     6241 tagatgtagt tgaatctatg ggaggaatga aagcggcatc aaagatattt aatccattgc
     6301 ttagacctct gcttggtata cctggaatag caggaatagc atttgtatct tcatttacta
     6361 gttcagatgt agcctcaata atgacgaaag aattatttga aagtggggaa ataacagatg
     6421 atgaaagaac tatatttgta gcatatcaat atgctggttc agctgttata ctgaacacaa
     6481 taaatactca agctccactt ttaccaatag cattattggc attaggtcca ataatactta
     6541 tagagatatt ctgtaaaata cttggtgcta atctagttag attaatcata ggtgtaagaa
     6601 ataaaaagaa taaggctaag gaggctgtgt agtatgagtc aacaaaatac tggaaatgta
     6661 attgtaaata gtaaacctaa gaaaactgct gttgagatat ttatgggggg agcaaaaaaa
     6721 ggtttttaca taggtgttga acagatatta ccagccatga taatgggtta tgtaatagtg
     6781 cagtttttac aattaactgg tttagttgat attttaggaa atatttttgg accagtaatg
     6841 ggtatttttg gactacctgg ggaatctgtt gtagttttga tagcagcatt ctttgctaag
     6901 gcagcaggag cagctacagc tgcaaactta tttgcacaag gtctaatcac tgcaccacaa
     6961 gcaaccatat taattatgcc atgtatgtta atgggtactc tagttggtca ttatgccaga
     7021 atagtgcttg tagcaaatgc cagtactaag tatagaatgt tactgttggc agttcctata
     7081 tttgatgcaa tagtggggat gttgatagta agagttttac tcactgttat gggattaatg
     7141 taaataacat aaaattataa cctaactata aatgatatat aagaattaat atatacaagg
     7201 attaatgagt agtaattgat atatagtaat aaactaagat agtaattaat gtgtatatta
     7261 attaaaaaaa gagagtatct caaagtgaac tttttagttc atgagatact ctttttgtat
     7321 gaaatcaagt atattttcat aatttcaaca atgaaagaga ggcttatctc tattttgaga
     7381 cagcctcttc ttttaaattt atatttctag aatttatgtt ttttatttat ccaacattaa
     7441 cattagttat tagcaataat tttaagaaaa atatactttc atgttaatat cagaataaat
     7501 gtgtttttaa aggatgattt gttttgaatt ttcacgaata tctacttcta tgactttttc
     7561 tattgtatct cctctaaaac ctaataaatt acttgtcaag tttgcagtgg aacaagaatg
     7621 attaggtata attcttattc tatcaccaat ttttatatca gtttcaccat ttactttaat
     7681 ttttccaact tcttctgaaa gtgaatcaat agtaagttct ggatgtccac ataccctacc
     7741 ataaccaaca atactactat ttccatgtgc acctttatca agtccaaggc acttacttcc
     7801 acaatcaatt aaatagtatc cactgctatt ttttgagatt acagtgcaca caacagtaag
     7861 agcacacata tcttcagtag cacaacctaa acctatctgt atagcatcat agtatacata
     7921 gtttccaggt cttacagcag ttatagtttt agaagcagct tcagattcaa ctgttggagt
     7981 actaccagaa gcgacaattt ctatattaaa tccattatca gttagagctt tgtatgcttt
     8041 ctccatagaa gaatcttctt gaacacaaac atctggaaca ccttctggag aactacaacc
     8101 atacacttga cctggatgcg aacttatacc aacaatcttg atgttttcta gcttagaaat
     8161 ttcagtagca agttcaacca ctttttctgg ttcaacccca aaacggtgta agccacaatc
     8221 tacaataata agtagcttgc actctatttt tgatttagaa aaagcttcac tataagcctt
     8281 agcacattct atattatctg tagcacagat taaatttatt tttgatgcca tagtcacaat
     8341 tctatttata tttacttctc ccatgtaagg ataagccaac ataatatctt caaaacctgc
     8401 ttttatcaga gcttcacctt catcaagtgt tccaactaga aaaccactag cacctgcatt
     8461 tttttgaagt ctcgctatgt aagtactttt atgtgtctta agcataggcc aaagttgttt
     8521 attattattt gtacaaattt gttgaatttt atctatattc ttttctaact ggtctaaatc
     8581 tagcaaaaaa tttggagtag cgacttctga aattttcatg ttatttacca cctttcaaca
     8641 aaagtaaatt aactataagt attataatta ttatattagt aatatcggct ttataatatt
     8701 aatagcttat aattatatta tagaactagc gttaacagag agcaatattt atttgtaata
     8761 atta
//
LOCUS       DAEHWM010000126         8724 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.129, whole genome shotgun sequence.
ACCESSION   DAEHWM010000126 DAEHWM010000000
VERSION     DAEHWM010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8724
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.129"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            231..1310
                     /locus_tag="KNP36_003355"
     CDS             231..1310
                     /locus_tag="KNP36_003355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBF0875201.1"
                     /translation="MPELLKNMYNRESLYEVAVAIQSVYNSFKVDEFIKSTMDETWNN
                     LELKARCRKISMSLGMYLPEDYKEALSILEKSVTGFYFAFFFPDFVEVYGQDDINWDL
                     SISALERNTEYWSSEFAVRAFIIKDEERMMAQMRKWSKHKSEHVRRLASEGCRPQLPW
                     GQAISKFKKDPTPVLPILEQLKTDTSTYVQKSVANNLNDISKTHPDLVISIVKDWYGK
                     NKSTNWIVKHGCRTLLKKGNRDVLALFGYDDTTSINLQDFTLETTSISIGEDLTFSFN
                     ILAKKATKTRLEYGIDYIKSNGKRNRKIFKISEVSLKENEKKSYMKKHSFADVSVRKH
                     YPGIHSIAIIINGIEKDKLDFELGI"
     gene            1634..2002
                     /locus_tag="KNP36_003356"
     CDS             1634..2002
                     /locus_tag="KNP36_003356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HBF0875202.1"
                     /translation="MNVYSFWNDTLAQDAVKIRKYFHEDAYINWHDTNEHFTLEEFII
                     ANCEYPDKWNGKVERVLEFGNLVITVTHVYAINKSLSFHVVSFISLKDDKIISIDEYW
                     GEDDDVPQWRLDKHIGKPIK"
     gene            2119..2922
                     /locus_tag="KNP36_003357"
     CDS             2119..2922
                     /locus_tag="KNP36_003357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0875203.1"
                     /translation="MEEKYILSDRGKVYYWIKESNSVFAKNLIFLPGLTANHHLFDFQ
                     IQYFSKNHNVLVWDAPAHGKSRPYLDFSYSNLVEELKVILDRQNMKKVVLIGQSAGGF
                     VAQSFIVKYPNMVEGLMMIGTCPYGTDYYSKSDIFWLKQTEWMLKLFPDKLLRNIISK
                     MCGATSEGRRSMLKMLEGYEKKELCHLMYMGFAGFIPEIQDLNIHCPVCLVVGDKDKT
                     GKVRKYNEQWHNKTGYPLHIIKNASHNVNVDKPNELNQIMDIFIKQLNI"
     gene            3314..4204
                     /locus_tag="KNP36_003358"
     CDS             3314..4204
                     /locus_tag="KNP36_003358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0875204.1"
                     /translation="MIESIPAKQILQKVKFDNTRWFGIDYNMNLYRGCSHGCIYCDSR
                     STIYNIENFDKVRYKENVIEILSKELRSKRKKGVVGIGAMSDTYNPFEKQLCITKQAL
                     DLISENHFGVSIDTKSSLVVRDIPILQKIKKNNSAIVKLTITTANDELSKKIEPYVNP
                     SSVRFDAVKELNDSGIFCGILLTPMLPFLTDNKDEIRAIVEKAHKANAKFIYCMYGVT
                     MRSGQREFFYEHLRDISPKLVLKYQKTYGLNYVCTVQNKDSCEKLLREECARYGILTD
                     MKDIIKAYKRSESYTQIKFF"
     gene            4767..5210
                     /locus_tag="KNP36_003359"
     CDS             4767..5210
                     /locus_tag="KNP36_003359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902048.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0875205.1"
                     /translation="MIEIKTIEINKKSRIDLLMLADPCEEMIDKYLNKGTMYALYDNK
                     ELTCIAVVNEISKEICELKNIATYEHFQNMGYASKMIYHLLDVYSKKYSSMVVGTSES
                     GVPFYEKFGFVYSHKIKNFFVDNYPEPIFEGELQCVDMLYLSYNF"
     gene            5382..5552
                     /locus_tag="KNP36_003360"
     CDS             5382..5552
                     /locus_tag="KNP36_003360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875206.1"
                     /translation="MDSNNNTIKSTVKKGISFGSCLAMIISYTAWKSIPWAIFHGLMS
                     WIYVLYYWVKYA"
     gene            5925..7022
                     /locus_tag="KNP36_003361"
     CDS             5925..7022
                     /locus_tag="KNP36_003361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBF0875207.1"
                     /translation="MKEKLEEKSKIIKTSKEYKRTIIEEKDREWTKKLNDILSRGDFS
                     NEKLDKIKDLIPKEILTSENVGEVVTEDGYAKPEYDEVFKSLFTLNNDYDLLANFIND
                     ILKDAPYANRNIKQFTQIKRIIKVETDPTINYIGEKRPRLDILAEDEERNHINIEMQR
                     ALEEDYLERAEYYLSRVHGRKLEEGKEYKEIGKTVGIHILNHVKYNHIEDYVNCLRLT
                     MDGHPDIYSSKTALYFIELPKIRKSSCIANRVLIWGKLIDNPSHIDIRILSKTDYVIK
                     RALDRLKELGSNEDYLLNLKRGAYIMNKSRNFKEEIFQEGIEKGIAKGKREEKFNIII
                     KLKNKGYNLSEICDIIDDLNKSEVEKVYNQN"
     gene            7227..7715
                     /locus_tag="KNP36_003362"
     CDS             7227..7715
                     /locus_tag="KNP36_003362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3841 domain-containing protein"
                     /protein_id="HBF0875208.1"
                     /translation="MKFYTIQTLEFWNNNKNNKYLSNDYSFILEDFDIPYKWMYSQMT
                     NRIYEFDDSMIWVWTKRPDLRCSGYLEKGKKGVLLEIEISEDNVLLSEFDLWHLPLMD
                     ITVELYEDEQIEKKVSWERIFDLELCSKLNEVNIEDLTLQGVTSKVPLSNVKLIKEFV
                     AK"
     gene            7801..8208
                     /locus_tag="KNP36_003363"
     CDS             7801..8208
                     /locus_tag="KNP36_003363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875209.1"
                     /translation="MSKQQTGIKSTLISEILGISYCIGATLVNKYFFKGSSIEYLPII
                     IWVLAMGAQWVYNKKYDDLIDEASKCILSRVNDIAIKVLFFSVAIVSIFLVTLDINVS
                     NLNIGMSLLVILFIQSLLKLILFIYFDRKGIYN"
     gene            8209..8427
                     /locus_tag="KNP36_003364"
     CDS             8209..8427
                     /locus_tag="KNP36_003364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875210.1"
                     /translation="MSVLLKTKIKSYREKNLMTQGELAKSVGVRRETIVHLENGRYNP
                     SLKLAMDIAKVFDTTVEELFEFIEENNI"
BASE COUNT         3425 a          859 c         1539 g         2901 t
ORIGIN      
        1 cagtaaagta taaaattcta ttactataat aaaagataga actagaagtc tttatgaaag
       61 tgggaaaagt atttatataa ataaattcat atagtttata gtttaatagt aggaaatatc
      121 gtatgagtaa gaatattgta ttttacataa agatttagca atatgacaca ctgttgtcgt
      181 gttctgtagg atatgattaa taaatcagat atgaaaggag agtgagtaat atgccagaat
      241 tactaaaaaa tatgtataat cgtgagtcac tttatgaagt tgcagtagct atccaatcag
      301 tttacaactc atttaaggta gacgagttca taaaatctac aatggatgag acatggaata
      361 acttagaatt aaaagccaga tgtcgaaaga taagcatgag tttaggaatg tatttaccag
      421 aagactataa ggaagctctt tccattcttg aaaaatcagt tacaggtttt tattttgctt
      481 ttttctttcc agattttgtt gaagtttatg ggcaggacga cataaattgg gatttatcta
      541 taagtgcatt agaaagaaat actgagtatt ggtcttcaga atttgctgta agagccttta
      601 tcatcaagga cgaagagcgt atgatggcac agatgcgtaa atggtctaag cataagagcg
      661 aacatgtacg aagacttgca agtgaaggct gtcgtcccca gttgccttgg ggacaagcaa
      721 tatccaaatt taaaaaagac cctacacccg tactgcctat attggagcaa cttaaaacag
      781 atacatcaac gtatgtacaa aagagtgttg ctaataatct aaatgatatc tcaaaaacac
      841 atccagattt agtcataagc attgtaaagg attggtacgg taaaaataaa tccactaact
      901 ggattgtaaa gcatggttgc agaactctac taaaaaaagg caatcgtgat gtattagccc
      961 tttttggata tgatgatact acttctataa atcttcagga ctttacttta gaaacaacgt
     1021 ctatttctat tggagaggat ttaacttttt catttaatat tttagcaaaa aaagcgacaa
     1081 aaacaaggct cgagtacgga attgattata ttaaatctaa tggaaaaagg aataggaaga
     1141 tatttaaaat atcggaggtt tcattaaaag aaaatgagaa aaagtcatat atgaaaaaac
     1201 attcatttgc agatgtaagt gtaaggaaac attatccagg tatacactcg attgctatta
     1261 ttattaatgg tatagaaaaa gataaacttg attttgaatt aggtatataa ttttactaac
     1321 agaataatct atatcagata ctttgctaaa cttatataat atattttact aaatttatat
     1381 taggtagttt actacttgtt tactgaattt aaatacaaag aaatacaggt gctaatccct
     1441 gcccattaaa ggaatatgag cataacacaa aagtagaact tatcaattct gttacgggta
     1501 tagtagtaaa tccatagaat cacaattaga agatgaagtg taaaaaataa gttagtgttg
     1561 attttagttg ctagtgatat tgaatagtta tacaatagcc atataaatta gaatttgtag
     1621 aggagaaata taaatgaatg tatatagttt ttggaatgac actttggcac aagatgctgt
     1681 taagataaga aaatattttc atgaagatgc ttatattaat tggcatgata caaatgagca
     1741 ttttacttta gaagaattta ttattgcaaa ttgtgagtat cctgataaat ggaatggtaa
     1801 agtagaaagg gtgctagaat ttggaaattt agtaattaca gtgacacatg tttatgcaat
     1861 aaataaatca ctatcatttc atgtcgtttc atttatcagc cttaaagatg ataagattat
     1921 ttctattgat gaatattggg gagaggatga tgatgtgcca cagtggagat tagataaaca
     1981 tattggaaag ccaataaaat agtgtttgtt ctgttttata actgaaattt tgataacatt
     2041 tgatattttg atttgtcatt ggtcaacata gtcgttagtg taataattta aaaaagtaga
     2101 atttggagag tgaacactat ggaagaaaaa tacatcttat ctgaccgagg gaaagtatat
     2161 tattggataa aagaaagtaa tagtgtgttt gcaaagaact taattttttt gccaggacta
     2221 acagcaaatc atcatctttt tgatttccag atacagtact tttcaaaaaa tcataatgta
     2281 ttggtatggg acgctcctgc tcatggaaaa tcaagacctt acttagattt ctcatattct
     2341 aacttggtag aagaattgaa agtaatttta gatagacaaa atatgaaaaa ggttgtactt
     2401 atagggcaat cggcaggggg atttgtggca cagtccttta ttgtaaaata tccaaatatg
     2461 gtagaaggac taatgatgat tggaacttgt ccatatggaa ctgactatta tagtaagtca
     2521 gatattttct ggttaaaaca gactgaatgg atgttaaagt tattcccaga taaattgttg
     2581 cgaaacataa tatctaagat gtgtggagct acgtctgaag gcagaaggag tatgctgaaa
     2641 atgttagaag gttacgaaaa aaaagaactg tgtcatctca tgtatatggg atttgctggg
     2701 ttcataccag aaattcaaga cttaaatata cattgtccag tttgtttggt ggttggagat
     2761 aaagacaaga cgggtaaagt gagaaaatat aatgagcagt ggcacaataa gactgggtat
     2821 ccattgcaca ttataaaaaa tgcttcacat aatgtaaatg tcgataaacc taatgaacta
     2881 aatcagatta tggatatatt tattaagcaa ttaaatatat aaaaactaca tactcattag
     2941 gtaaattatg tagtatatgt gtttacagat ggttatagaa ataaatatgt aataaactac
     3001 ttaacactta aaaagtggat ttgtccagag cataatacaa agcatgatat atataaattt
     3061 ttaagcgaaa tacatcaaaa gaaggattag aattagtgga gacagaacag ctattataga
     3121 ttataaataa atagttttaa aggagaggta ctacgaatat agaggaaggt aaatcatacg
     3181 ttattcaagt attataaatg attagtttaa aagtactatc ggataggagt ctccatattt
     3241 aaaccttagt aaaggtagtt aaagtagtag tttaaaaact aaaaaattat ataaaggaat
     3301 taggtataag aaaatgattg agagtatacc agcaaaacaa attttacaaa aagtgaaatt
     3361 tgacaataca agatggtttg gaattgacta taatatgaat ctctatcgtg gttgttctca
     3421 tggatgtata tattgtgata gccgtagcac aatatacaac atagagaatt ttgacaaagt
     3481 tagatataaa gaaaatgtga tagaaatttt aagtaaagaa ttgcgttcaa aaagaaaaaa
     3541 aggtgtagta ggcattggag ctatgtctga cacatataat ccttttgaaa agcaactttg
     3601 tattacaaag caagcactag atttgatttc ggaaaatcat tttggagtgt ctattgatac
     3661 taaaagtagt ttggtggtta gagatatacc gattttgcag aaaattaaaa aaaataattc
     3721 tgctattgta aagttgacta taaccactgc aaatgatgaa ttatcaaaga aaatagaacc
     3781 ttatgtaaat ccaagttctg tacgatttga cgcagtgaaa gaacttaatg attctggaat
     3841 tttttgtggc atattattga ctcctatgct tccatttttg actgataata aagatgaaat
     3901 acgagcaatt gtagaaaaag cacacaaggc taatgcaaaa tttatttatt gcatgtatgg
     3961 tgtaacaatg cgtagtggtc agagagagtt tttttatgag catttaagag atatatcacc
     4021 aaaattggta cttaaatatc agaaaacata tggtttaaac tatgtatgta ctgtacaaaa
     4081 taaagattct tgtgagaagt tgttaagaga agaatgtgca cgttatggta ttttgacgga
     4141 tatgaaagat attataaaag cgtacaagag gtcggagtca tatactcaaa taaaattttt
     4201 ttaagatagg ctttggatga gatataatag tgttgattga tgtgttgata ttatagttga
     4261 ttgttagaga ggatattata gatgaatatt agtattgata ttttaggtaa ttgttagagc
     4321 tgatattata gatgaatatt agtattgata ttctaggtaa ttgctagagt tagtattata
     4381 gatgaatatt agtattgata ctctaggtaa ttgctagagt tagtattata gatgaatatt
     4441 agtattgata ttctaggtaa ttgctagagc tgatattata atttattatt agtattgata
     4501 ttctaggtaa ttgctagagc tgatattata atttattatt agtattgata ttctaggtaa
     4561 ttgctagagt tagtattata gatgaatatt agtattgata ttctaggtaa ttgctagagc
     4621 tgatattata atttattatt agtattaata ttctagggaa ttatcactat attttaaaaa
     4681 gtaaaaatat atatcaaaat gaattaaata agtactgtaa gaagtttgtt aaattaaggt
     4741 ttgaataaag tgagggtgga gaacttatga tagaaataaa aactatagaa ataaataaaa
     4801 aaagtcgaat tgacctttta atgttagccg acccatgtga agaaatgatt gataaatatc
     4861 tcaataaagg aactatgtac gcattgtatg ataataaaga acttacttgt atagcagttg
     4921 taaatgaaat ttccaaagaa atatgtgaat taaaaaacat tgctacatat gagcattttc
     4981 aaaatatggg ttatgcctca aagatgattt atcatctttt agatgtttat agtaaaaaat
     5041 attcatcaat ggttgttggt acatctgaaa gcggagttcc tttttatgag aagtttggat
     5101 ttgtttattc acataaaatt aaaaactttt ttgtagataa ttatccagaa ccaatctttg
     5161 aaggagaatt acaatgtgtt gacatgttgt atctatcata taacttttag ataggataat
     5221 atttttaggt taatataatt aattaattca tataattatc ggaattataa tttataaatt
     5281 atgtataata agagtataat ttatttagaa gctgttatat tgtattatat tcaaataaga
     5341 tatataataa cttgtttatt ttgaattttg gaggattaat tatggattca aataataata
     5401 ctataaaatc aactgttaaa aagggtattt cttttggttc ttgtttagca atgattattt
     5461 cttatactgc atggaaatct attccatggg ctatttttca tggcttaatg agttggatat
     5521 atgtacttta ttattgggtt aagtatgcat agattaaatt aataaataag tatgtaatat
     5581 tgtaaagttt aagaaacaaa atgtaaggga gtgtctcgaa gtgaactttt agtttataag
     5641 gcactctttt ttgtattaaa taaaatatat tttcattatt taaacaatga aaaagatgag
     5701 tatctctatt ttaatacata cccttatatt cattcattta tcaacaatag ttttaaaaag
     5761 aaagctatct aaaatctatt gtaatctaag tgcttctctt taaagtctta actttagtaa
     5821 tgatatataa gtttataagg ttcttatttc aataatgcaa attttactta gaagttcaga
     5881 ctttggtatg aagaaatggg taataataaa aaagaggtgt tgatatgaaa gaaaaattag
     5941 aagaaaaatc taagattatt aaaacatcaa aagagtataa acgaactata attgaagaaa
     6001 aggacagaga atggaccaaa aaattaaatg acatacttag tagaggtgat ttttctaatg
     6061 aaaaattaga taaaatcaag gatttaattc caaaagaaat attgactagt gaaaatgttg
     6121 gagaagttgt aactgaagat gggtatgcta agcctgagta tgatgaggta tttaaatcat
     6181 tgtttacttt aaataatgat tacgatttac ttgcaaattt tataaatgat atcctcaaag
     6241 atgctccata tgctaatagg aatatcaaac agttcactca aataaaaaga ataattaagg
     6301 ttgaaaccga cccaacaatt aattacattg gtgagaaaag acctagactt gatattttgg
     6361 ctgaagatga agaacgtaac catataaata ttgagatgca aagagctctt gaagaggatt
     6421 atttggaaag agctgaatat tatcttagtc gtgtacatgg tagaaagtta gaagaaggta
     6481 aagaatataa agaaattgga aaaactgttg gaatacatat actaaatcat gtaaaatata
     6541 atcacataga agattatgta aattgcctga gattaacaat ggacgggcat ccagatattt
     6601 attctagtaa aactgcatta tattttatag aacttccaaa aattcgtaaa tccagttgta
     6661 tagcaaacag agttctaata tggggtaaac ttattgataa tccttctcat atagatatta
     6721 gaatactatc taaaacggat tatgttatta aaagagcact tgatagatta aaagaattag
     6781 gtagtaatga ggactattta ttaaatttaa agagaggtgc gtatattatg aataaaagta
     6841 gaaattttaa agaagaaatt tttcaagaag gtattgaaaa aggtattgca aaagggaaaa
     6901 gagaagagaa atttaatatc atcataaaat taaaaaataa aggatacaat ttgagtgaaa
     6961 tatgcgatat tatagatgat ttgaataaat cagaggttga aaaagtctat aatcaaaact
     7021 aatactatga ttgagatggc actagataaa tacaaagctt cctcttttaa atttaaatta
     7081 atataaaact ttgttattta aatatggtag atataaagag atatataaat aataggtaca
     7141 aagaggtgta taaataaagg agataattca aaataaaagt ttgaaccatc tccttcttat
     7201 agaaaaacaa aggggttgat ttatatatga aattttatac tatacagact ttagaatttt
     7261 ggaataacaa taaaaacaat aaatatctat caaatgatta ttcttttata ttagaagact
     7321 ttgatattcc atacaaatgg atgtatagtc aaatgacaaa tagaatatat gaatttgatg
     7381 atagtatgat atgggtttgg acgaagagac ctgatttaag atgtagtggt tatttagaaa
     7441 aaggaaaaaa aggtgtttta cttgaaatag aaataagtga agacaatgtg ttattatcag
     7501 aatttgattt atggcattta cctttaatgg atattactgt agagctttat gaagatgaac
     7561 aaattgaaaa gaaggtaagc tgggaaagaa tatttgactt agaactgtgt tcaaaattaa
     7621 atgaagttaa tatagaagat ttgacattgc aaggagtgac atctaaagtg cctctatcta
     7681 atgtaaaatt aataaaagaa tttgttgcaa aataatattt ttattgaaat ttattcaaaa
     7741 aagttatata tttataacaa gaggtgttat aaatacataa ctttttaagg gggattttat
     7801 atgtctaaac aacaaactgg tattaaatca acacttattt cagaaatatt gggaatttct
     7861 tattgtattg gagctacatt agtaaataag tattttttta aaggaagtag tattgaatat
     7921 cttcctataa ttatttgggt attagctatg ggagctcagt gggtctataa taaaaagtat
     7981 gatgatttaa ttgatgaggc atcaaaatgt atactatcaa gagttaatga tattgcaata
     8041 aaagtattgt ttttttctgt agctatagta tctatatttc ttgtaacttt ggacataaat
     8101 gtgtcaaatt taaatatagg aatgtcttta ttagtcattt tgtttattca atccttgttg
     8161 aagttaattc tatttatata ttttgacaga aaggggatat acaattaggt gtcagtatta
     8221 ctaaagacaa aaattaaatc ctatagagaa aagaacctta tgacacaagg tgaacttgca
     8281 aagtcagtag gagtaagacg tgaaactatt gtacatttag aaaatggtcg ctacaatcct
     8341 tctttaaaac tggcaatgga tattgctaag gtatttgata caactgtaga agagttgttt
     8401 gaatttattg aagaaaataa tatttaaatt tcatgtatta cttatgcatt agagaatgaa
     8461 ttaattatag gtaaaaaacc aagcttatag attagagaat aaatgactta tagatgaaaa
     8521 accaagctca tagattaaag aatgaatgat ttatagatga aaaagaaagc ttatagatta
     8581 gagaataaat gatttatagg taaaaaccaa gctaatagat taaaaaatga atgatttata
     8641 gattaagaag taagctaata gattagagaa taaatgactt ataaataaaa accaagctaa
     8701 tagattagag aataaatgac tcat
//
LOCUS       DAEHWM010000127         8477 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.130, whole genome shotgun sequence.
ACCESSION   DAEHWM010000127 DAEHWM010000000
VERSION     DAEHWM010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8477)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8477)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8477
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.130"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            75..1976
                     /locus_tag="KNP36_003365"
     CDS             75..1976
                     /locus_tag="KNP36_003365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0875211.1"
                     /translation="MRERIILETLKNSSGYLNIDYFADKLGVSTRTIRNEIKKIETIK
                     ECNGFKLEYKSKLGYILNIKDQDKFEHYLRNLPSDLVENPEQRLESIIVELLVNEGYK
                     TIEQLSKKFLVSSSQIKNDLKKIDEKIKDTELKLERKAHYGIKIEGSIKEIQSILVDS
                     YFRGNRNITEYRNKFIDNLKLANIRSTIKNVLNEHDLEANLTELEEILAQIIILYIRV
                     SMRVVGNASDLKLYTEDLIIDKLLDKIFRDKKYNLNYDEKYYLKELIKLKTKDKKATI
                     KNIDKNKLQDIMFEFFREIDKKYNSNFLEDKEFFNLFYLHIACLIERIKKNHKIINPF
                     SVKISQQYPTVFNLSIQFSKIIENEYHIKISQDEIGFIATHIAVPFEKREEANFNKKY
                     KIAIICSSGGGSAFLINLRLKEIFPNAEIRNFSLLEEKAVIEFAPDLIFSITNLLFEI
                     NAPVILINEILDELDYLDIKESVRFADHIGNISSPKQYILGLFDKNHFRCIKDKAKYK
                     DILDSMSKCIVDEGACSPTYPKDVWERESYLSTIYTNGVAIPHPIEMTGNKNIISVAL
                     IQTDIIYENRVPKIIFMISLIKGNLELHKQISKYLSKIMANKDMVDMLNKSQSYEEFM
                     YKLKIYLGG"
     gene            1979..3022
                     /gene="ypdE"
                     /locus_tag="KNP36_003366"
     CDS             1979..3022
                     /gene="ypdE"
                     /locus_tag="KNP36_003366"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HBF0875212.1"
                     /translation="MNIEFFKRLSEADGIASNEEEVRHVLLEELKAYSDKIICDGLGS
                     IIFSKIKDESAPNVMICAHMDEVGFMVRSIDKLGMIHLITIGGVKPLAQFVQKVRITT
                     KEGKKIPAVINATYNNGKAENIYADIGAYTEEDVYNLGINVGDMVTYTTSFEEFTLPD
                     RLVGKAFDDRIGCFVMGEVLKELRKENLNCNIHFAATSSEEVGIRGAKTSTQLINPDI
                     VFVIDVACAKNEFVRDYTNKKQIDKGVMLMHRDRTLVPSRKMIDYVMEIADKNNIPLQ
                     HDMFESGGTDGGEAHLVNEGKPCVVTCVPVRYGHCAFSIVSNKDLENIIRLYTQLILN
                     FDEEQYKHIRNFI"
     gene            3037..3342
                     /locus_tag="KNP36_003367"
     CDS             3037..3342
                     /locus_tag="KNP36_003367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HBF0875213.1"
                     /translation="MSTEVQIMELISTAGESKSKAFEALKKVKSKDFKGAKLLIEEAR
                     KIDIEAHRIQTELITQDLNEDVESPAMSLLMVHAQDHYMTSQLAKDLIEALIYCLDK"
     gene            3439..3774
                     /locus_tag="KNP36_003368"
     CDS             3439..3774
                     /locus_tag="KNP36_003368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0875214.1"
                     /translation="MKILLCCAGGFSTNMLMQNMKKVVKESAKLNEKDFEFTAIPADS
                     IESEVDDWDIVLIGPQIAHKIDFLKGILEPKNKPFAVIDKDVYGKMDGATVMKLALIT
                     YKKHQLAQG"
     gene            3806..5128
                     /locus_tag="KNP36_003369"
     CDS             3806..5128
                     /locus_tag="KNP36_003369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0875215.1"
                     /translation="MFSKFEAFMNRVFMPLAHKVDNQRHLGSIKAGMVAMTPFTILGS
                     IFAILPALPNMLGENNPISKFILSNSAILDLPVSLSIGLIGLYACMCIAFNLGNYYKL
                     YIPGCVALSTFSFLFLVASFTPDGALEIGNLGAKGLFTGMIAGLGSVELYNFCNKKNI
                     TIKMPENVPDFVSRSFELIPTTIIVCGTFIVARFISLKVFGELPPQILTQFLSPLVGS
                     MDNPWSVLALNFAICTIFFFGIHSSVFSPITRPIMITFIAENIAAMQAGETIPHFFTA
                     GASSAFFGFTGCGISIGCVIACMLSKNASYKKIGRVSLFPALFGINEPILFGAPIILN
                     PIMFIPHVFGGAIIGTLPMFFMHWGWLAKPVFDPPYVGVFLEGFLTNGDWHSILANAL
                     QLVLAVLLYWPFFKIMERQQNNKKQKEETKNIFSKEEEGLLDDLGLDF"
     gene            5138..6208
                     /locus_tag="KNP36_003370"
     CDS             5138..6208
                     /locus_tag="KNP36_003370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0875216.1"
                     /translation="MNNTMERLVSLIYKRGVDALLIKAKNTKRYIGALSGSGVYVLVT
                     KDKNYQILDGRYIDEADKKTTGFIKRIVSQGSYIPTIIELLKELNIKKLAIENQAMSI
                     QEYLSLKNEGFEINLITNELWKLRAIKSKEEIKLIKKACEITDEVFDEVISEIKKDMT
                     ELEVSALIQYHALKKGASGMSFETIVVSGERGAMPHGRPTNKKLKVNEAITIDFGVVY
                     QGYQSDMTRTISIGKPPKIIKEIYDVVLEAQLSAIESIKEGTRASDVDKVARKIIDKH
                     GFGEYFNHGLGHGIGLGDGEVPTLNPNSEDILVEGMVMSCEPGIYIPNVGGVRIEDDI
                     VIIDGKGVPLNKTSKEFIILGE"
     gene            6213..7400
                     /locus_tag="KNP36_003371"
     CDS             6213..7400
                     /locus_tag="KNP36_003371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0875217.1"
                     /translation="MKYNFNKVLNRKEGNCRKWSNHVIKEKFGLNEDAIPMDLADIDF
                     ECAPAIKESILKRASVGDYSYTFIGDDFYDAIINWNKRRFDVYIEKDWIKLTFGTVST
                     LHYIVQAYTKEGEGVLINTPAYDPFAEAVVNNNRKLCCSSLKLDNNRYYLDLEDMENQ
                     MKYENIRLLIFCSPQNPSGRIWTKEELYQVSELCLKYNVILVSDEIHRDIIFKDYRFV
                     SLWNAHPEIYKNSIICVSPNKGFNLGGLKTSYVLIRDVKIRETLLERLKSNSITSPNV
                     FAIPAIVAAYNESEEWLDAMTSYVEENFEIVYDFFETNIPKAKVMKSDSSFLAWIDVR
                     EVFRNEEESKEFFRHANLTMVVGSYFVKDGDGFIRINVGCPRETLNEALNRIKKTYIS
                     MYC"
     gene            complement(7597..8469)
                     /locus_tag="KNP36_003372"
     CDS             complement(7597..8469)
                     /locus_tag="KNP36_003372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898679.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose 1-epimerase family protein"
                     /protein_id="HBF0875218.1"
                     /translation="MNILQNENLIIESSSFGAELTKIFSKKYDKNILWDGNKKYWGRQ
                     SPILFPIVGKLFDNETIIEENLYSMTQHGFARDMDFEIVDKGDTFVTYKLTDNESTLK
                     KYPYSFELIINYTLNDNSIEVEWIVKNTDSKDIFFSIGGHPAFNLPFYEQNDFSKHYL
                     EFKSKNDVEKINLNGSFTDDIIPIGKLKNLQLNPEVFKNDALIYTNIDEVSICNNDGS
                     KYVTISMEDFPLVGIWTPYYSETNSTAPFLCIEPWYGLADSINSNKIYKDKKFINKLS
                     KGKVFTASYNINIH"
BASE COUNT         3287 a          937 c         1500 g         2753 t
ORIGIN      
        1 aaggttgttt ttataaaaaa tattttttat accactttaa aaaacacaat aataacactg
       61 agggaggtgg ggatatgaga gaacgcatta ttcttgaaac attaaaaaat agtagtggtt
      121 atctaaacat agattatttt gcagataagt tgggggtatc tactcgaact atcagaaatg
      181 aaataaaaaa gatagaaact ataaaagaat gtaatggttt taaattagaa tataagtcta
      241 aattaggata tattctaaat attaaagacc aagataaatt cgagcattat ctaagaaact
      301 taccctcaga tttagttgaa aatccagaac aacggttgga gtctataata gtagagcttt
      361 tagtaaatga aggttataaa actatagaac agttaagtaa aaaatttcta gtaagttcat
      421 cccaaataaa aaatgattta aaaaagatag atgaaaagat aaaggataca gaattaaaac
      481 tagagcgaaa ggctcattat ggaattaaaa tagaaggttc tataaaagaa attcaaagta
      541 tattggtgga tagttatttt agagggaata gaaatataac agagtacagg aataagttta
      601 tagataattt aaaattagct aatattagaa gtacaataaa aaatgtactt aatgaacatg
      661 atttagaagc aaatttaaca gaacttgagg aaatattagc acaaattatt atattgtata
      721 taagagttag tatgagagta gtgggaaatg ctagcgattt aaaattatat acagaagatt
      781 taattataga taaattatta gataaaattt ttagagataa aaaatataac cttaattatg
      841 atgaaaagta ttatttaaag gagcttataa aactaaagac taaagataag aaagccacta
      901 taaagaatat tgataagaat aaacttcaag atattatgtt cgaatttttt agagagatag
      961 ataaaaaata taactctaat tttttagaag ataaagagtt ttttaactta ttttacttac
     1021 atattgcatg tttaatagaa cgtataaaga agaaccacaa gataataaat cctttttcag
     1081 ttaaaataag tcaacagtat ccaactgttt ttaatttatc tattcaattt tcaaaaatca
     1141 tagaaaatga gtatcatata aaaataagtc aagatgaaat agggtttata gctactcaca
     1201 ttgctgttcc ttttgaaaag agagaagaag ctaattttaa taaaaaatat aaaatagcaa
     1261 taatatgctc ttctggtgga ggtagtgcat ttttgataaa tttaagactt aaagaaattt
     1321 ttccaaatgc tgagataaga aatttttcat tactagaaga aaaagctgta atagaatttg
     1381 caccagattt gattttttca ataacaaatc ttttatttga aataaatgct ccagttatac
     1441 ttataaatga aattttagac gaattggatt atttagatat taaagaaagt gttagatttg
     1501 cagaccatat aggaaatata tcaagcccaa aacaatatat attaggtcta tttgataaga
     1561 atcactttag gtgtataaaa gataaagcta agtataagga tatccttgat agtatgtcaa
     1621 aatgtatagt tgacgaggga gcttgttctc caacctatcc caaagatgta tgggaaagag
     1681 aaagttattt gagtactatt tatacaaatg gggtggctat acctcatcca atcgagatga
     1741 caggaaacaa aaatataata tcagtagctt tgatacaaac tgatattatt tatgaaaata
     1801 gggtgcctaa aattattttc atgatttcat taataaaggg aaatttagaa cttcataagc
     1861 aaatatctaa atatttaagt aagattatgg caaataagga tatggtagac atgctaaata
     1921 agtcacaatc ttatgaagag tttatgtata agttaaaaat ctatctggga ggttagacat
     1981 gaatatagag ttttttaaga ggttgtcaga agcagatggt atagcatcta atgaagaaga
     2041 ggttagacat gttttattgg aagaactaaa agcttatagt gataaaatta tctgtgatgg
     2101 gctagggagt atcatctttt ctaaaataaa agatgagagt gcaccaaacg taatgatttg
     2161 tgctcatatg gatgaagttg gatttatggt gagaagtata gacaaacttg gtatgattca
     2221 cttaataaca ataggaggag taaaacctct tgcacagttt gtacaaaaag ttagaattac
     2281 aacaaaagaa gggaagaaaa tccccgctgt cataaatgct acatataata atggtaaggc
     2341 tgaaaatata tatgcagata ttggagcata tacagaagaa gatgtatata acctagggat
     2401 taatgttggg gatatggtaa catatacaac aagctttgag gaatttactt taccagaccg
     2461 attagtggga aaggcttttg atgataggat aggatgtttt gtgatgggag aagttttaaa
     2521 agaacttagg aaagaaaatc taaattgtaa tattcacttt gcggctacaa gtagtgaaga
     2581 ggttggaata aggggagcaa agacatcaac acagttaata aatccagata tagtatttgt
     2641 aatagatgta gcatgtgcta aaaatgagtt tgtgagagac tatacaaata agaaacaaat
     2701 tgataaaggt gtaatgctaa tgcatagaga taggactcta gtccctagta gaaaaatgat
     2761 agattatgta atggaaattg ctgataaaaa taatatacca cttcaacatg atatgtttga
     2821 atcaggtggg actgatggag gagaagcaca tctcgtaaat gaagggaaac cttgtgtagt
     2881 aacttgtgta ccagttagat atggtcattg tgcattttca atagtaagta ataaagattt
     2941 ggagaacatt ataagattgt atacacagtt aattttaaat tttgatgaag aacaatataa
     3001 acatataaga aattttatct aaaggagaat aagaaaatgt caacagaagt acaaataatg
     3061 gaacttatat caactgcagg agagagtaaa tcgaaagctt ttgaggcttt aaaaaaagtg
     3121 aagtcaaaag attttaaagg agcaaaattg ttaatagagg aggctcgtaa aatagatatt
     3181 gaagctcaca ggatacaaac agaattaata actcaagatt taaatgaaga tgttgaaagt
     3241 ccagcaatga gtcttttaat ggtacatgct caagaccact atatgacttc tcagctagca
     3301 aaagacttga tagaggcttt gatatattgt cttgataagt aattgtaata tagaaataga
     3361 ttatttatgt aaaaattctt ttaaaagttt agatgctttt aagagataat aaaaatacaa
     3421 actttaggag gaattattat gaaaatatta ttatgttgtg caggtggatt ttctactaat
     3481 atgttaatgc aaaatatgaa aaaggtggta aaagagagtg ctaaactcaa tgaaaaagat
     3541 tttgagttta cagctatacc agcagattca atagaaagtg aagttgatga ttgggatata
     3601 gtacttatag gtcctcaaat agctcacaaa atagacttct taaaaggaat attagagcca
     3661 aaaaataagc cttttgcagt aatagataaa gatgtatatg gaaaaatgga tggagctaca
     3721 gttatgaagt tggcattaat aacttataag aaacatcaat tagctcaagg ataataaaaa
     3781 taatgaggga aaagggagat tagatatgtt ttcaaaattt gaagcattta tgaatagagt
     3841 atttatgcct ttagctcata aggttgacaa tcaacgtcac cttggttcta taaaggctgg
     3901 tatggttgct atgacaccat tcacaatatt aggaagtata tttgcaatac ttccagcact
     3961 tccaaatatg cttggagaaa ataatccaat aagcaaattc atacttagca attcagcaat
     4021 attggattta ccagtaagtc tttccatagg tttaatagga ttatatgctt gtatgtgtat
     4081 tgcttttaat ctggggaact actataaatt atatatacca ggttgtgttg cactatcaac
     4141 tttttctttt ttattcctag tagcctcatt tacaccagat ggagctttag aaataggaaa
     4201 tttaggagct aaagggctat ttacaggtat gatagcaggg cttggttctg tggagttata
     4261 taatttttgt aataagaaga atatcacaat aaaaatgcca gaaaatgtac ctgattttgt
     4321 atctaggtct tttgaattaa tacctactac tataatagtt tgtggaactt ttatagttgc
     4381 tcgttttatt tcattaaaag tatttggaga attacctcca cagatactta ctcaattttt
     4441 atctccatta gtaggaagta tggataaccc atggtcagtt cttgcactta actttgctat
     4501 atgtactata ttcttttttg gaatacattc atcagtattt agtcctataa ctagacctat
     4561 aatgattaca tttatagctg aaaacatagc agctatgcag gctggagaaa caatacctca
     4621 tttctttaca gcaggagctt caagtgcatt ctttggattt acaggatgtg gaattagtat
     4681 aggttgtgta attgcatgta tgttatcaaa aaatgcttcc tataagaaga ttggacgtgt
     4741 atcattattc cctgcattat ttgggataaa tgaaccaata ttatttggag caccgataat
     4801 attaaatcca ataatgttta taccacatgt atttggtgga gctataatag gtacactacc
     4861 aatgtttttt atgcactggg gatggttagc aaagccagta tttgaccctc catatgtagg
     4921 ggtattctta gaaggatttt taactaatgg agattggcat tctatattag caaatgcatt
     4981 gcaattagta ttagcagttt tattatattg gccattcttt aaaataatgg aacgtcaaca
     5041 aaataataaa aaacaaaaag aagaaactaa gaatatattc tctaaagaag aagaaggctt
     5101 attggatgat ttaggattgg atttctaata ttttgttatg aataatacaa tggagagatt
     5161 agtatcctta atctataaaa gaggtgttga cgctcttttg attaaagcaa aaaatactaa
     5221 aagatatata ggagctttat caggtagtgg tgtatatgtg cttgttacta aggataaaaa
     5281 ttatcaaatt ctagatggca gatatattga tgaagcagat aaaaaaacga ctggtttcat
     5341 aaaaaggatt gtatctcaag gttcttatat accaactata attgagttat taaaagaatt
     5401 aaatataaaa aagttagcaa tagaaaacca agctatgagt atacaagagt atctttcact
     5461 aaaaaatgaa ggttttgaaa tcaatttaat aacaaatgaa ttatggaagc taagggctat
     5521 aaaatctaaa gaagaaatta aacttattaa aaaggcttgt gagattacag atgaagtatt
     5581 tgatgaggtt atttctgaaa ttaaaaaaga tatgactgag ctagaagtat cagctctaat
     5641 tcagtatcat gcattaaaaa aaggtgcaag tggaatgtct tttgaaacaa tagtggtatc
     5701 aggagaaaga ggtgcaatgc cacatggaag acctacaaac aaaaaattga aagtgaatga
     5761 agctataaca atagattttg gtgttgttta tcaagggtat caatcagaca tgactcgtac
     5821 aatatctata ggcaaacctc ctaaaattat taaagagata tatgatgtag tattggaagc
     5881 acaattatct gcaatagagt caataaagga aggaactagg gcaagtgatg ttgacaaagt
     5941 ggctagaaaa attatagata aacatggatt tggcgaatat tttaatcatg gactgggtca
     6001 tggtataggt cttggagatg gtgaagttcc cactttaaat ccaaatagtg aagatatatt
     6061 agtggaagga atggtaatgt cttgtgagcc aggtatttat attccaaatg tagggggagt
     6121 tagaatagaa gatgatattg ttataataga tggaaaaggt gttccactca ataagacatc
     6181 caaagagttt ataatattag gagagtaaaa ttatgaaata taattttaat aaagtattaa
     6241 atcgtaaaga aggaaattgt agaaaatgga gcaaccatgt gattaaagaa aaatttggct
     6301 taaatgaaga tgcaattcct atggatttag ctgatatcga ttttgagtgt gctcctgcta
     6361 taaaagaatc tatcttaaaa agagcatcag taggagatta tagttatact tttataggag
     6421 atgacttcta tgatgctatt ataaattgga ataaaagaag atttgatgta tatatagaaa
     6481 aggattggat aaaattaact tttggtactg tttcaaccct tcattatata gtccaagcat
     6541 atactaaaga aggagagggt gtattgataa atacacctgc ttatgaccct tttgcagagg
     6601 ctgtagtaaa taataataga aagttgtgtt gtagctcatt aaaattagat aacaatagat
     6661 attatttaga tttagaggat atggaaaatc aaatgaaata cgagaatata agattgctta
     6721 tattctgtag tccacaaaat ccatcaggtc gtatatggac aaaagaagaa ctatatcaag
     6781 tgtcagagtt atgtttaaag tataatgtaa ttttggtaag tgatgaaatt catagagata
     6841 taatatttaa agattataga tttgtatctt tgtggaatgc tcatccagaa atttataaaa
     6901 atagtataat ctgtgtatct cctaataaag gcttcaactt aggtggatta aaaacatcat
     6961 atgtattaat aagagatgta aaaattaggg agactttatt agaaaggcta aaaagtaatt
     7021 caataacttc tccaaatgta tttgcaatac cagcaatagt tgcagcatat aatgaaagcg
     7081 aagaatggct agatgctatg actagttatg tagaggagaa ttttgaaata gtttatgatt
     7141 tctttgaaac taatatacca aaagctaaag tgatgaagtc agactcttct tttttagcct
     7201 ggatagatgt aagagaagta tttagaaatg aagaagaatc taaagaattt tttagacatg
     7261 caaacttaac tatggtagtt ggaagttatt ttgtgaaaga tggagatgga tttattcgta
     7321 ttaatgtggg gtgtcctaga gaaacattaa atgaggctct aaatagaatc aaaaaaacgt
     7381 atataagtat gtattgttaa atcataaaaa aagtatctat ggtttatata aaaacacatt
     7441 atttagttat caaatattac tggaattttg tattccagta atattttttg attaaggaat
     7501 attattgagg aatattaaat aatattattt cataccctta tattaactta tataaaaata
     7561 ttttattatt ttgggaacgg gttagctaac ctttatctag tgtatattta tattgtaaga
     7621 agcagtaaaa acttttcctt tactaagttt attaataaac ttcttatctt tataaatttt
     7681 gttagaattt atactatcag caagaccata ccaaggttct atacataaaa aaggagcagt
     7741 agaattagtt tcactataat aaggagtcca aataccaact agagggaaat cttccataga
     7801 tatagttaca tatttactac catcattatt acatatagac acttcatcta tgttggtgta
     7861 tatcaaagca tcattcttga atacttctgg atttaactgt aagtttttta attttccaat
     7921 aggtattata tcatctgtaa aagaaccatt taaattgatt ttttctacat catttttact
     7981 tttaaactca aggtagtgtt tagaaaaatc attttgttcg taaaaaggaa ggttgaatgc
     8041 aggatgtcca cctatagaaa agaatatatc tttagaatca gtatttttta caatccattc
     8101 tacctcaata ctattatcat ttaatgtata gtttatgatt agctcaaaag aatatggata
     8161 cttctttaaa gtagattcat tatctgttaa tttataagtt acaaatgtat ctcctttatc
     8221 tacaatctca aagtccatat ctctagcaaa cccatgttga gtcatgctat ataaattttc
     8281 ttctattatt gtttcattat caaaaagttt acctactata gggaacaata taggtgattg
     8341 tctaccccaa tattttttat taccatccca aagaatgttt ttgtcgtatt ttttagaaaa
     8401 tattttagtt agttcagcac caaaactgct tgattcgata attaaatttt cattttgtaa
     8461 tatattcatt taaaatc
//
LOCUS       DAEHWM010000128         8475 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.131, whole genome shotgun sequence.
ACCESSION   DAEHWM010000128 DAEHWM010000000
VERSION     DAEHWM010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8475)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8475)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8475
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.131"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(205..2799)
                     /gene="clpB"
                     /locus_tag="KNP36_003373"
     CDS             complement(205..2799)
                     /gene="clpB"
                     /locus_tag="KNP36_003373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent chaperone ClpB"
                     /protein_id="HBF0875219.1"
                     /translation="MDVEKMTLRVQKSLNEAYNEAVKNHNQQVDVIHLFSALINQEDG
                     LIPNIIEKMNISIDSLRNTVNFEIDKLPKVYGEGADSQGVSATRKINEVLIKAESISK
                     EFKDSYISVEHVMLAMMETESKSAVGKILKQYNINKNNFLNILSQVRGSQRVETQDPE
                     GTYDALARYGTNLVDLAKKNKLDPVIGRDEEIRRIIRILSRRTKNNPVLIGEPGVGKT
                     AIVEGLAERIVRGDVPEGLKDKIVFSLDMGALIAGAKYRGEFEERLKAVLKEVQSSDG
                     KIILFIDEIHTIVGAGKTEGSMDAGNLIKPMLARGELNCIGATTFDEYRKYIEKDKAL
                     ERRFQPVIAEEPTVEDTISILRGLKERFEIHHGVRIHDNAIVAAAKLSHRYIQDRFLP
                     DKAIDLIDEAGAMIRSEIDSLPTELDVVRRKLFTLETEREALLKENDDKSKSRLDDIQ
                     KEIAELKSKNDEMTAKYEKEKSQILDIKNLKAQLDEAKGKAEKYEREYDFNKAAEVKY
                     GEIPKLEEQIKQYEENMNDGSENSLLKEEVTEEEISSIVSKWTGIPVTKLVEGEREKL
                     LKLEDELHKRVIGQDEAVTAVSNAVIRARAGLKDERKPIGSFIFLGPTGVGKTELAKT
                     LARNLFDSEDNIIRIDMSEYMEKHAVSRLVGPPPGYVGYEEGGQLTEAVRRAPYSVIL
                     FDEIEKAHEDVFNMFLQILDDGRLTDNKGKTVDFKNTLIIMTSNIGSNYLLEAGGNIT
                     ETTNNLVMNEMKHRFKPEFLNRVDDIIMFKPLDQENIKKIIDIFMKDLKNRLKEKDIT
                     IEVTNSAKDVMVREGYDPVYGARPLKRYIGNTLETIIAKKLIAGDVYNGCTIVIDGKD
                     ENIEVLVK"
     gene            complement(2836..3432)
                     /locus_tag="KNP36_003374"
     CDS             complement(2836..3432)
                     /locus_tag="KNP36_003374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875220.1"
                     /translation="MSLKLDRNVLQWFDYVFENEKTSLRHYNFNCTLKEISSTSLNKV
                     AFILEKNNSKYWKLYFEIPAEVTLKLKQNIHPLFREYIYEQISLYNNNQIYNFVNSNI
                     LKVFNNIAIYQYNILENLYTIDFKKSFIDKCQYLLIGEKRLIDEDLYLIAKSKEVFDF
                     FNLDGTFNLTLSFDIQKNENLLDSLLELRKSIIINERI"
     gene            complement(3449..3853)
                     /locus_tag="KNP36_003375"
     CDS             complement(3449..3853)
                     /locus_tag="KNP36_003375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication/maintenance protein RepL"
                     /protein_id="HBF0875221.1"
                     /translation="MDKTLKKDLNQEYTESKSLIMNKSKYMNVCFKNYIKVVEGMYTK
                     RDLIPLKLINSMDKNNKIRKTLYELSCEFEYPKTSLSSLFTELKKMDFLQRVKNGEYM
                     INPHIAYKGSRADKESLLAEYNQIKRPNKVSK"
     gene            4220..4594
                     /locus_tag="KNP36_003376"
     CDS             4220..4594
                     /locus_tag="KNP36_003376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424232.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0875222.1"
                     /translation="MNIVISNSSGKPIYEQITTQIKSMIISGELPEGSALPSMRLLAK
                     ELRISVITTKRAYSDLERDGFIETVTGKGSFVSSKNMDFVKEEQFRLIEEYLQKAVDT
                     AKSSDITYDELKDILFLLYKGE"
     gene            4591..5454
                     /locus_tag="KNP36_003377"
     CDS             4591..5454
                     /locus_tag="KNP36_003377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875223.1"
                     /translation="MISMDAITIKNLNKTYKDFSLQDISFSVPKGSVMGFVGENGAGK
                     TTTLKAILNLISYDSGNIEIFGLDSKKNEKEIKEQIGVVFEGSNFHENLNTDHVSKIM
                     SKIYKNWNDTLFKDYLKKLRVPDNKLIKEFSKGNKMKLSIAVALSHKPKLLILDEATS
                     SLDPIVREEILDIFLDFIQDEEHSIILSSHITSDLDKIADYITFIHKGKIVFSENKDE
                     LIDTMGVLKCKPSDFDNLSREDYSYYRKSQFGYEVLLKDKHRFISRHPNCIVDNTSIE
                     EIMLFYVRGDK"
     gene            5454..6092
                     /locus_tag="KNP36_003378"
     CDS             5454..6092
                     /locus_tag="KNP36_003378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 transporter permease"
                     /protein_id="HBF0875224.1"
                     /translation="MKGLILKDLLNLKGNIKFILLFIIMFGFMSSLGDGNVNNFIGVI
                     IVLCTTMIVSTFSYDDLNKWDSYVLTMPINRNDIVLSKYLTMLIFSFIGVLVSLIVSV
                     TIGYFKNTLILNETLLINALILSISVCFGSLILPLIYKFGTERARLLMILCFLVPTLA
                     LLVFKSILENISSPISIEIILNTLVYSLPFVAILLFVISYFISSKIYSKKEV"
     gene            6584..6997
                     /locus_tag="KNP36_003379"
     CDS             6584..6997
                     /locus_tag="KNP36_003379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0875225.1"
                     /translation="MELEITEKIEKQDEDTIFQGLLKYNLARLEDKNPVDLGIYIRDK
                     AGKIVAGFIGVTHGNWLSIKYLWVSEKLRYKGTGSQLLYKAEKIAKERGCKYVFLDTF
                     SFQAPKFYEKFGYHKVFSLENYPLTGKRYYYRKIL"
     gene            7188..8405
                     /locus_tag="KNP36_003380"
     CDS             7188..8405
                     /locus_tag="KNP36_003380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallo-hydrolase"
                     /protein_id="HBF0875226.1"
                     /translation="MLGKKCMDYLQTLGKISSTTNGLTRLILTQEHKKSIDLISSWME
                     GLNLDIEIDDIGNVIGTYKSSFPNAPTLVVASHQDSVKCGGIFDGMLGIIVPLVGLEE
                     AKHNNRSYPFNIKLIAFAEEEGTRFETSLMGSKVFAGTFKEELLKSVDENGITLEEAV
                     TKFGFNTKNLTNLHPRKDVDAYLEFHIEQGPVLENESLPAGIVSSITGFKSFKISVNG
                     KSGHAGTLPMNMRLDAGCCACECVLAIEKVAKTTTDLVATVGKMNFYPSSSNVVPERA
                     EFTLDVRSCSQEILDNSVEKIFNEISHICENRKLNYTSELAFENVPVPCSNKITKIIE
                     KSFIDLNLNPFYIYSGAGHDAQEMDNITDIGMVFIRCAGGVSHNPNESVSVDDLDTAV
                     KIFLKILDNLDLK"
BASE COUNT         2928 a         1184 c         1049 g         3314 t
ORIGIN      
        1 gaacaatagt ttttataatt atattcaaat tatgattata ttataagaaa tttactaaaa
       61 tacttccttt gagttaaatt taatttggac atattgactt aaaaatgttt tattaatttg
      121 ataaaatatt tcttttccta tagtttataa ataaaaatca gctgagcaaa atatttagta
      181 tattatgctc aactgattct tttattattt aactaaaact tcaatatttt catcttttcc
      241 atctataact atagtacatc cattatacac atctccagca ataagtttct ttgcaattat
      301 agtttctaat gtatttccta tatatctctt aagaggtctt gctccatata cagggtcata
      361 tccttctctc accataacat cttttgctga atttgtaact tcaatagtaa tatctttttc
      421 ttttaatcta ttttttaaat ctttcataaa tatatctata attttcttga tattttcttg
      481 gtctaaaggc ttaaacatta taatatcatc tactctgttt aaaaactcag gtttaaatct
      541 atgcttcatt tcattcatta ctaaattgtt agtagtctct gttatatttc ctcctgcttc
      601 taatagataa ttacttccta tattagaagt cattattata agagtatttt taaagtctac
      661 tgtcttacct ttattatcag taagtctacc atcatctaat atctgtaaga acatgttaaa
      721 tacatcctca tgtgcttttt ctatctcatc aaatagtatt acagaataag gagcacgtct
      781 aactgcttct gtaagttgac caccctcttc atatcccacg taccctggag gaggtccaac
      841 tagtcttgat acagcatgtt tttccatgta ttcagacata tctattctta ttatattatc
      901 ttcactatcg aataaatttc tagcaagagt ttttgcaagt tcagttttac caacacctgt
      961 agggcctaag aaaataaatg aaccaattgg ttttctttca tcttttaatc ctgctcttgc
     1021 acgtattact gcatttgaaa ctgctgtaac tgcttcatct tgtccaataa ctcttttatg
     1081 aagttcatct tctagtttaa gtaatttttc tctttctcct tcaactagtt tagttactgg
     1141 tatacctgtc cactttgata caatgctaga tatttcttct tcagtaactt cttcttttaa
     1201 aagagaattt tcagaaccat cattcatatt ttcttcgtac tgctttattt gttcttctaa
     1261 cttaggtatt tcaccatatt taacctctgc tgctttgttg aaatcatatt ctctttcata
     1321 cttttcagct ttacctttag cttcgtctaa ttgagccttt aagtttttaa tatctaatat
     1381 ttgactcttt tctttttcat attttgctgt catttcatca tttttagatt ttaactctgc
     1441 tatttctttt tgaatatcat ccaatcttga tttactttta tcatcatttt ctttaagtaa
     1501 tgcttctctt tcagtttcta atgtaaataa ctttcttcta acaacatcta attctgttgg
     1561 caatgaatct atttcactac gaatcatagc tccagcttca tcaattaaat caattgcttt
     1621 atctggtaaa aatctatctt gtatatatct atgagaaagt tttgctgctg ctacaatagc
     1681 attatcatgt attcttactc catgatgtat ctcaaatctt tcttttaaac ctctaagtat
     1741 agatattgta tcttcaacag taggttcttc tgcaattaca ggctgaaaac gtctttcaag
     1801 agccttatct ttttctatat actttctata ttcatcaaaa gtagttgcac caatacagtt
     1861 caattcacct cttgcaagca taggtttaat aagattacct gcatccattg aaccttctgt
     1921 tttaccagct ccaacaatag tatgaatctc atctataaac agtataattt ttccatcaga
     1981 actttgaact tcttttaaaa ctgcctttaa tctttcttca aattcacctc tatattttgc
     2041 accagcaatt aaagctccca tatcaagtga gaatacaatc ttatctttta aaccttctgg
     2101 gacatctcct cttactattc tctctgctaa cccttctaca attgcagttt tacctacacc
     2161 tggctcacca atcaatacag gattattttt tgttcttctt gataaaattc ttataatcct
     2221 tcttatttct tcatctctcc caattacagg gtctaattta tttttcttgg ctaaatctac
     2281 taaatttgtt ccatatctag caagtgcatc atatgtgcct tctgggtctt gtgtttctac
     2341 tctttgacta cctctcactt gtgataaaat atttaaaaag ttattcttat ttatattata
     2401 ttgttttaat attttaccaa cagctgattt tgattctgtt tccatcattg caagcataac
     2461 atgctctaca cttatatatg aatctttaaa ttctttagaa atactctctg cctttataag
     2521 cacctcattt atttttctag tagctgatac tccttgtgag tcagcacctt ctccatatac
     2581 ctttggaagc ttatcaattt caaagtttac agtatttctc aaagaatcaa ttgatatatt
     2641 cattttttcg attatatttg gtatcaatcc atcctcttga ttaataagtg ctgagaaaag
     2701 atgaattaca tctacttgtt ggttatgatt ttttactgct tcgttataag cctcatttaa
     2761 acttttttga actcttaaag tcattttttc tacgtccata taaatccctc cattttaata
     2821 ttatatccaa ataaattaaa ttctctcatt tataattatt gattttctaa gctctaaaag
     2881 actatcaagt aaattctcgt ttttttgtat atcgaaactc aatgttaaat taaatgttcc
     2941 atctaaatta aaaaaatcga atacttcttt tgattttgct attaaataca agtcttcatc
     3001 tataagtctt ttttcaccta ttaataaata ctgacattta tctataaaac tctttttaaa
     3061 atcaatagtg tatagatttt ctaaaatatt atattgataa atagcaatat tattaaacac
     3121 ttttaatatg tttgaattta caaaattgta aatttgatta ttgttataca gtgatatttg
     3181 ttcgtatata tattccctaa ataaaggatg aatgttttgc ttaagtttta aagtaacttc
     3241 agctggtatt tcaaaataaa gcttccagta cttagagtta tttttttcta aaataaaagc
     3301 tactttgttc aaactggtag aactaatctc ctttagtgta caattaaaat tatagtgtct
     3361 caaactagtt ttttcattct caaatacata gtcaaaccac tgtagaacat ttctatcaag
     3421 ttttaaactc atataaaaac cttcttcctt atttactaac cttattaggt ctttttatct
     3481 gattatattc tgctaataaa ctttctttat cagctctact acctttatat gctatatgtg
     3541 gatttatcat atactcacca tttttcactc tttgtaaaaa atccattttt ttcagctccg
     3601 taaacaatga agataaagaa gtttttggat attcaaattc acaagataat tcatataatg
     3661 tttttctaat cttattattt ttatccatag agtttattaa ttttaatgga attaaatccc
     3721 tcttagtata cattccttct actactttaa tataattctt aaaacaaaca ttcatatact
     3781 tacttttatt cataattaaa cttttgctct ctgtatattc ctgatttaaa tcctttttta
     3841 atgtcttatc caaattaaat atctcttctc actctcctta tctctaattg ataatataaa
     3901 tatattacaa aaaaatatgt atgtcaaaac tgaaaatgca aaaagttcac cttataagta
     3961 aacttttatt tagctataag ctaaacttta ttattttttt aatttagtat ttccaattta
     4021 ttggcaggat ttttgaacaa tatttataaa ttttttaaaa aaatttaaat ctatttaata
     4081 tggcagactt tcataaaata cattacattt attaaatgta taatattggt aattagtttt
     4141 ttctaaaatc agttgacata ttatatatat atttatataa tgtgtatata ctatatatac
     4201 aatttaagga ggtgtcttat tgaatatagt tattagtaat tcgagtggga agccaatata
     4261 tgaacagatt actacacaaa ttaaaagtat gattataagt ggagagttac cagaaggctc
     4321 agctcttcca agtatgagac tattggcaaa ggaacttaga ataagtgtaa ttactacaaa
     4381 acgagcatat agcgatttag aacgagacgg atttattgag acagttactg gtaaaggcag
     4441 ttttgtatct agtaaaaaca tggattttgt caaagaagaa caatttcgtt taattgaaga
     4501 atacctacaa aaagcagttg atacagcaaa aagtagtgat attacatatg acgaattaaa
     4561 agatatttta tttttattat ataaaggaga atgataagta tggatgcaat aactataaaa
     4621 aatttaaata aaacttataa agattttagc ctacaagata tatctttttc agtaccaaaa
     4681 gggagtgtaa tgggatttgt aggtgaaaat ggtgcaggaa aaacaactac attaaaagca
     4741 attttaaatt taatatctta tgatagtgga aatatagaaa tctttggtct tgatagtaaa
     4801 aaaaatgaaa aagaaattaa agagcaaatt ggggttgtat ttgagggaag caactttcat
     4861 gaaaatttaa acactgacca tgtttcaaaa atcatgagta aaatctataa aaattggaat
     4921 gacacattat ttaaagacta cttaaaaaaa ttgagagtac cagacaataa attaattaag
     4981 gagttttcaa aggggaataa gatgaaactt agtattgctg tagccttatc tcataaacca
     5041 aaattattaa tactagatga ggcaactagt tcacttgacc ctatcgttcg tgaagaaata
     5101 ctagatatat ttttagattt tatacaagat gaagaacact ctattatctt atcttcacat
     5161 attacaagtg atttagataa gatagcagac tatattacat ttatacataa aggaaaaatt
     5221 gtatttagtg aaaataagga tgaattaatt gatactatgg gagttttaaa atgtaaacct
     5281 agtgattttg ataacctttc aagagaggat tattcatatt atcgtaaaag ccaatttgga
     5341 tatgaagtac ttcttaaaga taagcataga tttatctcaa gacatccaaa ctgtattgtt
     5401 gataatacgt ctatagaaga aattatgtta ttttatgtga gaggtgataa ataatgaaag
     5461 gtctaatttt aaaagattta cttaatttga aaggaaatat aaagtttata cttttattca
     5521 tcattatgtt tggctttatg tcttctttag gagatggaaa tgttaataac tttataggtg
     5581 ttattatagt tttatgtact acaatgattg tttcaacatt ttcatatgat gatttgaata
     5641 aatgggatag ttatgtactt acaatgccta ttaatcgcaa tgatattgta ttaagtaaat
     5701 atttaactat gttaatattt agctttatag gtgttcttgt ttcacttatt gttagtgtaa
     5761 ctattggtta ttttaaaaat acacttatat taaatgaaac actacttatt aatgcactaa
     5821 tcttatcaat ttcagtatgt tttggtagcc ttattctacc acttatttat aaatttggta
     5881 cagaaagagc tcgtttatta atgattttat gctttttagt tccaacacta gctttattag
     5941 tttttaaaag tattttagaa aatattagtt cacctatttc tatagaaatt atacttaata
     6001 cactagtata ttctcttcca tttgttgcta ttttactatt tgtgatttca tattttatat
     6061 catcaaaaat ctatagtaaa aaagaagtat aaaatatact atatatgttt ctgtatttaa
     6121 gtatttaaat aaaatactat cgagtttatt ttggtagtat tttatttttt aattattaat
     6181 ctctactagg tatttattat tttattactt atatttaata agactattta ctactttcta
     6241 atcttattta tataatttat tcattttata aattgaacta ctaatgatat tattgaacat
     6301 agcaatagaa taacatctaa aatagttttt atgtattaaa ttaacttatt ttaatattca
     6361 acaatttagg tttactaaat ttattgatga tttcttttta tataacttaa actacatttt
     6421 tatttaaaaa aatttaatat caacaatata aaattaagaa taagtattat tagtttgaca
     6481 ttagcataaa tgcctattag aataatgtta aactatattc tttctactga ttttattaaa
     6541 aaataccaat atacaaaaga ttatacaagg agaaagttca aatatggaat tagaaattac
     6601 agaaaaaata gaaaaacaag atgaagatac tatttttcaa ggattattaa aatataatct
     6661 tgctagactt gaagataaaa acccagtgga tttaggaata tatattcgag ataaagcagg
     6721 taaaattgtt gcaggtttta taggtgttac tcatggtaat tggctttcta taaaatactt
     6781 atgggttagt gagaagctta gatataaagg tactggaagt caacttttat ataaggctga
     6841 aaaaattgct aaagaacgag gttgtaaata tgttttttta gatacattca gttttcaagc
     6901 acctaaattt tatgagaaat ttggatacca taaagtattt tcacttgaaa attatcctct
     6961 aactggaaag agatattatt atagaaaaat actataataa taaaaatcat atttcatatt
     7021 tttaaattaa aacttctgct cttcgtctac agactttatg tttttatatc attattaata
     7081 ctaaaatagt attttactat acatacaaaa ttatttgaaa gttcaaaaat tataagtata
     7141 aaagctaatc ttagcttaaa taaaaattat atttttagga ggtaaatatg ttaggaaaaa
     7201 aatgtatgga ttatctacaa acattaggaa aaataagttc aacaacaaat ggtcttacaa
     7261 gacttatctt gactcaagaa cataaaaaat ctattgattt aattagttca tggatggaag
     7321 gtttaaatct tgatattgaa attgatgaca ttggaaacgt tataggtaca tataaatcaa
     7381 gctttccaaa tgctcccaca ttagtagttg catctcatca agatagtgta aagtgtggag
     7441 gtatatttga tggtatgtta ggtataatag tgcctctagt tggtcttgaa gaagcaaaac
     7501 acaataatag gtcttatcct ttcaatatta agctaattgc tttcgctgaa gaggaaggaa
     7561 ctagatttga aacttcttta atgggaagta aagtttttgc tggtactttt aaagaggaac
     7621 ttcttaaatc tgttgatgaa aatggaatta cacttgaaga agctgtaaca aagtttggat
     7681 ttaatacaaa aaacttaaca aatttgcatc ctagaaaaga tgtagatgca tatttagaat
     7741 ttcatattga gcagggtcct gttttagaaa atgaatctct tcctgctgga attgtatcaa
     7801 gtattacagg atttaaaagt tttaagatat cagtaaatgg taagtctgga catgctggta
     7861 cacttccaat gaatatgaga cttgatgctg gatgttgtgc ctgtgaatgt gtattagcta
     7921 tcgaaaaagt agctaaaacg actactgatt tggttgctac tgtaggaaag atgaatttct
     7981 atccatcttc atcaaatgtg gtacctgaaa gagctgaatt tacactcgat gtacgctctt
     8041 gttcacaaga aattcttgat aattctgtag aaaagatatt taatgaaata tcacatatat
     8101 gtgaaaatag aaaacttaat tatacaagtg aacttgcttt tgaaaatgtt cctgtaccat
     8161 gttctaataa aataacaaaa atcatagaaa aaagttttat agatttaaat cttaatcctt
     8221 tttatattta tagtggtgct ggccatgatg ctcaggaaat ggataatata actgatattg
     8281 gtatggtatt tataagatgc gctgggggcg taagtcataa tcctaatgaa agtgtctctg
     8341 tagatgactt ggatactgct gtaaaaatat ttttaaaaat actagataat cttgatttaa
     8401 aataattctt atataagaaa gtatattaaa atatataatc taaaaaatca ctttatattt
     8461 atattatata agtgt
//
LOCUS       DAEHWM010000129         8459 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.132, whole genome shotgun sequence.
ACCESSION   DAEHWM010000129 DAEHWM010000000
VERSION     DAEHWM010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8459)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8459)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8459
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.132"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            167..1153
                     /locus_tag="KNP36_003381"
     CDS             167..1153
                     /locus_tag="KNP36_003381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HBF0875227.1"
                     /translation="MKKITINDIANLAGVSKSTVSRYLNNKDISDSTKEKIKTIIDEY
                     GYEPNAFAQSLRAKKTYFIGIITPCLDSFVKSKIMMAIDEELKELKYTSLIINTNRKI
                     RSEIDSISKLASLKVDGIILIGTEITKEHKNEIEKLDIPIVVVGQKVDGINSIVNDDY
                     GAGYKMGQYIANKGYKNIVYLGVDESDISVGLNRKNGVLNGLKDKGYDAKVFYTDFDQ
                     ETSIQRSGEMLESENPDIIICATDNIAIATMKEINKRGKNIPQDISVAGFGGYDVLSI
                     ISPKLTTIKFENKNAGKVAANTIVNLIQERKEPLLKEIKFELIEGESTINKN"
     gene            1322..1470
                     /locus_tag="KNP36_003382"
                     /pseudo
     CDS             1322..1470
                     /locus_tag="KNP36_003382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423822.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIB"
     gene            1489..2970
                     /locus_tag="KNP36_003383"
     CDS             1489..2970
                     /locus_tag="KNP36_003383"
                     /EC_number="3.2.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="HBF0875228.1"
                     /translation="MYKEPKYRTILESTKEELNKLRNISLNDKYKPLFHIHPQHGLLN
                     DPNGLAYYNGKYHVFYQWYPYDATHGMKHWAYVSSDDFVNWNREDVALIPIESYESHG
                     AYSGNAIEVDGKLHMYYTGNIKYSAEDRYAYQNLAIMNKDGKITKYENNPIVSEIPKG
                     YTGHVRDPKVFKRKDKYFMLLGAQTSDKKGAIIVYESKNSIDWNFKGELNVKNIDEDF
                     GYMWECPDYINIDEKDILIFSPQGVEPKGFDYQNIYNVVYAIGNMDLDNLTFEIDTMK
                     ELEKGFDFYAPQTFIKDSQIILFAWAGMGEVLYPTDKNKWAHCLTVPRKLNIKNNKLL
                     QMPVDELIKLRYDETSGQNTIKNNINIIENDENVYELNINIKNIDSNKFGLELFSSQD
                     EGVKLEFNKLGNIVTLDRSNFKKVFGVEYGTNRKEYINIDENTNIKVLADRSILEIFI
                     NEGEVVFTSRIFAKENSNQIRVYSDKIVEYEYTKFKLKQGIEL"
     gene            2996..3967
                     /locus_tag="KNP36_003384"
     CDS             2996..3967
                     /locus_tag="KNP36_003384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate kinase"
                     /protein_id="HBF0875229.1"
                     /translation="MKKVISIGEALIDFIPNQNGGKLKNVSEFRRVAGGAPANVSAVV
                     AKLGGKSSFISKLGKDAFGDYIIDVLNEVNVNTDYVLRTSKANTGLAFVSLKEDGNRD
                     FSFYRNPSADMLLEADEVKKEWFNNCHILHFCSVDLIDSPMKLAHKKAIEYALESNSI
                     ISFDPNIRLPLWDSEQSCKKAISEFLPFAHIVKISDEELEFITGENDIEKSLHKLFVG
                     NVELVLYTKGKDGVDAYTKKVKGMCKGVKVNAIDTTGAGDSYIGSFLYTLLYKQITLN
                     DIKEMKQETLNEYLEFSNYYAARSTTIKGAISSYATKEEITEFIKNL"
     gene            complement(4223..4825)
                     /locus_tag="KNP36_003385"
     CDS             complement(4223..4825)
                     /locus_tag="KNP36_003385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0875230.1"
                     /translation="MEVCILMGSPKKKGNTAAILKPFIEELENYNSNIEVIWLYDCKI
                     EPCIACKKCQDNLFDFGCYCKDDVQKIFKKILMCDLIVFATPIYSWYCTSPMKALLDR
                     LVYGMNKYYGNEKGPTLWAGKPVALITTCGYRPEKGADIWENGMKRYCKHSQLKYIGM
                     LVERDLGKPNFMNKEKEEHSRQFAKQIYYILDNSIEVDNC"
     gene            5106..6317
                     /locus_tag="KNP36_003386"
     CDS             5106..6317
                     /locus_tag="KNP36_003386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="HBF0875231.1"
                     /translation="MYSNEDYKFIEENAPCYIYDETNIIEKCKELKNNILGFDFLYSI
                     KTNPYNKIVKSIAEQGFGADASSTNEVMISSECGVSKDDIYYSSPGKTEIDIETVLDK
                     CIIIADSITEIELINKISKKYNQKVKIGIRINPDFTMDDDSAKSSKFGIDIEDMSSVF
                     KMLSMCDYVSVVGIHIHIKSQVLDFEKLGHYYEKCFFIALNLNKSKYINIEFINFGSG
                     LGVAYDNLRENPLNLKELSKLTQKIAFTNSNTLKSRLLIESGRFIVCKSGNYYVKIVD
                     IKVSRGKKYLIVKNGLNGFMRPIISNLIENITCGVELEGQEPLYTSNHAFSLSVLNNL
                     KEEEYVNVVGNLCTSLDVIANNVKLKKANIGDLISISNAGSYSYSLSPLLFSSYEFPK
                     QYYKRKDGYIE"
     gene            6385..6582
                     /locus_tag="KNP36_003387"
     CDS             6385..6582
                     /locus_tag="KNP36_003387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug transporter"
                     /protein_id="HBF0875232.1"
                     /translation="MELWKRNLFVCWIGMFFSSIGMSQIAPILSLYIKQLGVTDVSLI
                     QQYSGIVFGCTFVVAAFFSPI"
     gene            6616..7587
                     /locus_tag="KNP36_003388"
     CDS             6616..7587
                     /locus_tag="KNP36_003388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0875233.1"
                     /translation="MLLRASIGMGIVIFTMAFVQNVYQLLGLRILQGVFTGYATACTT
                     LIATQTDKNHSGWALGTLATASTTGSLIGPTVGGYIESILGLKSTFIITGGLLFVSFI
                     ISILFVVDNFKPKEIKESISIPKEQLNILPNKFLIASIFVTTFITQLALYSIEPIVTI
                     YISQLTNFASNVALIAGLTFSASGLANLLAAQKLGKMSDKIGPQKVLLISLLWAGIIF
                     IPQAFVKTAWQLMLLRFLLGLSVAGLNPSVNSLLKKIAPEEYVGKIFGYNASAQYIGC
                     SSGAFLGGQISAHLGIRTVFFSTSLLLFMNALWMYKFTGLFIKDKTK"
     gene            7774..8151
                     /locus_tag="KNP36_003389"
     CDS             7774..8151
                     /locus_tag="KNP36_003389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875234.1"
                     /translation="MTISKIPQAELKVMKFIWEKNDTVTSKETIEAMERKYGWKQTTT
                     LTLLSRLVKKHFLSAEKIDRYTHYTIVVGHKEYLSVETKDFLSNIHDNSLQSLISALH
                     DDEVVDKDMLDLFESHFKNLEEE"
BASE COUNT         3435 a          885 c         1353 g         2786 t
ORIGIN      
        1 aaaatgaaaa ttacaattaa tttaatgtta aagactcaat tatttggatg tggaatggat
       61 agtacaagta gtatataaaa agtattgact ggacaaataa ctatatttta ttttaaatat
      121 ataatataat gtaataaaat atatcaaatg tagaaggtga taacctatga aaaaaataac
      181 aataaatgat attgctaact tggcaggagt atctaaaagt actgtatcaa gatatctaaa
      241 taataaagat atcagtgatt ctactaaaga gaaaataaag acaataatag atgaatatgg
      301 atatgagccg aatgcatttg ctcaaagttt gagagctaaa aaaacatact ttattggtat
      361 tataacaccg tgtttagatt cttttgtaaa atctaaaatt atgatggcaa tagatgaaga
      421 actcaaagaa ttaaaatata catcactaat tattaatact aatagaaaaa taaggtcaga
      481 aatagatagt atatcaaaat tagctagtct aaaagttgat ggaataatac taattggtac
      541 cgaaataact aaagaacata agaatgaaat tgaaaagtta gatataccga tagttgtagt
      601 tggacaaaaa gttgatggta tcaatagcat agtgaatgat gattatggag caggatataa
      661 aatgggtcaa tatattgcta ataaaggtta caaaaacatt gtatatttag gtgttgatga
      721 aagtgatata tcagttggtt taaatagaaa aaatggagta cttaatgggt taaaagataa
      781 agggtatgat gcaaaagtat tttatactga ctttgaccaa gaaacgtcta tacaaagaag
      841 tggagaaatg ctagaaagtg aaaatccaga tataataata tgtgcaactg ataatatagc
      901 aatagcaaca atgaaagaaa tcaataagag aggtaaaaat ataccacaag atatatctgt
      961 agctggattt gggggatatg atgtattgtc tattataagc cctaaactta caacaataaa
     1021 gtttgaaaat aaaaatgcag gtaaagtagc agcaaatacg atagtaaatt taatacaaga
     1081 aagaaaagaa ccactattaa aggagattaa atttgaatta atagaaggtg aaagtacaat
     1141 aaataaaaat taagatacac attacatata ttagtaatgt gtattttttt actaaaaaaa
     1201 ctataattct aaaaattagg aaaacttttt tgaaagaaat attgcatctg aaataaattt
     1261 atgctaatct ttaattaaac cggtttcgaa accggtttaa ttaaaccgat agaatagcaa
     1321 aatgagtgca aaaataactg attgtaacaa agtatcaaag taattattag agtacatagg
     1381 aataaacaaa atataaaaga tgtagcacat tgtgtaataa gactaagaat tgttttagat
     1441 agcaataata aagcaaatat aaaattataa aagaaaagga ataaaaatat gtacaaagag
     1501 cctaaatata gaaccatatt agaatcgaca aaagaagaat taaataaatt aagaaatata
     1561 tctttaaatg ataaatataa accactattt catatacatc cacaacatgg actacttaat
     1621 gacccaaatg gattagcata ttataatggt aagtatcatg tattttatca atggtatcca
     1681 tatgatgcaa ctcatggaat gaagcattgg gcttatgtaa gttctgatga ttttgtaaac
     1741 tggaatagag aagatgtagc attaatacca atcgaaagtt atgaatctca tggagcatat
     1801 tcaggtaatg cgatagaggt agatggaaaa ttgcatatgt attatacagg gaatataaaa
     1861 tatagtgcag aagatagata tgcatatcaa aacttagcta taatgaacaa ggatggtaaa
     1921 ataactaaat atgaaaataa tccaatagta agtgaaatac caaaaggata tacaggacat
     1981 gtaagagacc caaaagtatt taaaagaaag gataaatact ttatgttact tggagcacaa
     2041 acaagtgata aaaaaggagc tataatagta tatgaatcta aaaactctat agattggaat
     2101 tttaaaggag aattaaatgt aaaaaatata gatgaagatt ttggttacat gtgggaatgt
     2161 ccagattata ttaatataga tgaaaaagat atattaatat tttcaccaca aggagtagaa
     2221 cctaaaggat ttgattatca aaatatatat aatgtagtat atgctattgg taatatggat
     2281 ttagataatt taacatttga aatagataca atgaaagaac tggaaaaagg atttgatttc
     2341 tatgctccac aaacatttat aaaggactca caaataatac tatttgcatg ggctggaatg
     2401 ggagaagttt tataccctac agataaaaac aaatgggcac attgtctaac tgttccaaga
     2461 aaattaaata taaaaaataa taagctattg caaatgccag tagatgaatt aattaaatta
     2521 agatatgatg aaacaagtgg gcaaaatact ataaagaata atattaatat tatagaaaat
     2581 gatgaaaatg tatatgagct taatattaat ataaaaaata ttgacagcaa taaatttggg
     2641 ctggaattat tttcatcaca agatgaaggt gtaaaattag aatttaacaa attaggaaac
     2701 attgtaactt tagacagaag caactttaaa aaagttttcg gtgttgaata tggaacaaat
     2761 agaaaagaat atataaatat tgatgaaaat actaatatca aagtactagc ggatagaagt
     2821 attttagaaa tttttataaa tgaaggagaa gtagtattta ctagtagaat atttgctaaa
     2881 gaaaattcta atcaaataag ggtttatagt gataaaatag tagagtatga gtatactaaa
     2941 tttaaattaa agcaaggtat tgaattataa aaacacatta taaggggtag aaaagatgaa
     3001 aaaagtaatt agcataggag aagctttaat agactttata ccgaatcaaa atggtggtaa
     3061 attaaaaaat gtatcagaat ttagaagagt agcaggagga gctccagcaa atgttagtgc
     3121 tgttgtagca aagcttggag gaaaatcgag ttttatatct aagttaggaa aagatgcatt
     3181 tggtgattat ataatagatg tattaaatga agtaaatgta aatactgatt atgtattgag
     3241 aacaagtaaa gcaaatacag gacttgcttt tgtatcatta aaagaagatg gtaatcgtga
     3301 tttctcattt tatagaaatc caagtgcaga tatgctttta gaagctgatg aagttaaaaa
     3361 agagtggttt aataattgtc atatcctaca tttttgttca gtagatttaa tagatagtcc
     3421 aatgaaatta gcacataaaa aagcaataga atacgcactt gaaagtaata gtataataag
     3481 ctttgaccct aatataagat tacctttatg ggatagtgag caatcttgta aaaaggcaat
     3541 atcagaattt ttaccttttg ctcatattgt taagatatct gatgaagaat tagaatttat
     3601 aacaggagaa aatgatatag aaaaatcatt acataaactc tttgtgggga atgttgaact
     3661 agtattatat acaaaaggaa aagatggagt agatgcatac actaaaaaag taaaaggtat
     3721 gtgtaaaggg gttaaagtaa atgcaataga tacaaccgga gcaggagatt cttatatagg
     3781 ttcattttta tacaccttat tgtataaaca aataacattg aatgatataa aagaaatgaa
     3841 acaagaaacg ttaaatgagt atttagaatt ttctaattat tatgcagctc gtagtacaac
     3901 tattaaaggt gcgataagtt catatgcaac aaaggaagaa ataactgaat ttataaaaaa
     3961 tttatagtag gaatgagtaa taggttttga aggaagtaac atgtaaagag tttttaagga
     4021 tgtttactat gaaaataatt aacatataaa aagcaataaa gaggctgtct caaaatagag
     4081 ataagcctct ttatcattgt tgaaatgata aaaaatattt taattattgt tactttttag
     4141 aagaatatat atcttatttt aaataagcaa attatgtaag atttatttat attatcaata
     4201 ctttacttgg agtattatgt ctttagcagt tatctacttc aattgaatta tctaaaatat
     4261 aataaatttg ttttgcaaat tgacgagaat gttcttcttt ttctttattc ataaaattag
     4321 gtttacctaa atcacgttca acaagcattc ctatatattt taactgtgaa tgcttacagt
     4381 agcgcttcat accattttcc caaatatcag cacccttttc aggtctatat ccacatgttg
     4441 taataagtgc tactggtttt cctgcccata gagtggggcc tttctcatta ccatagtatt
     4501 tattcattcc atacaccaat ctatcaagta gtgctttcat tggagaagtg cagtaccaag
     4561 aataaattgg agtagcaaaa acaattaaat cacacataag aattttcttg aaaattttct
     4621 gaacatcatc tttacaataa catccaaaat caaataagtt atcctgacat tttttacaag
     4681 caatacatgg ctctatttta caatcatata accatattac ttcaatattt gaattataat
     4741 tttctaattc ctcaataaaa ggttttaaaa tagcagcagt attacctttt ttcttaggac
     4801 ttcccataag aatgcatact tccatattga tacctccaca gtattttaaa atagttttta
     4861 gtgcttaata tagttttagg atactatgag aatacgttaa caacaataca ctttgtatat
     4921 ttgtaataaa attgaaacaa attgttttat caataaaagt tggaatgtat ctataattaa
     4981 aaatatttta ggtatgtttt tacatatatg tgtgtagtta actatggtaa tttattgtaa
     5041 aattatctta taggattata attgcttaat ttatgattat atttaaaatc ttggaggtaa
     5101 aaaatatgta ctcaaatgaa gactataaat ttatagaaga aaatgcacca tgttatatat
     5161 atgatgagac taatataatt gaaaaatgta aggaattgaa aaataatatt ttaggttttg
     5221 attttttata ttctataaaa acaaatccat ataacaaaat tgtaaaaagc attgcagagc
     5281 aaggttttgg agcagatgct tcttcaacta atgaagttat gatttcatca gaatgtggag
     5341 tttctaaaga tgatatttat tattcatcac caggcaaaac agagattgat atagaaactg
     5401 ttttagataa atgcataatt attgcagata gtattacaga aatagaactt ataaataaga
     5461 tatctaaaaa gtataatcag aaagttaaaa taggaataag aataaatcct gattttacta
     5521 tggatgatga tagtgctaaa tcaagcaaat ttggtataga tatagaagat atgagcagtg
     5581 tttttaagat gttaagtatg tgtgattatg tatctgtagt tgggattcat atacatatta
     5641 aatctcaggt attggatttt gaaaagttag gacattatta tgaaaaatgt ttttttatag
     5701 ctttaaattt aaataaaagt aagtatatta atattgaatt tataaatttt ggtagtggac
     5761 ttggagtagc ttatgataat cttagagaaa atccacttaa tcttaaagag ctttcaaaat
     5821 taactcaaaa gattgctttt actaattcaa acacactaaa atcaagactt cttattgaat
     5881 caggacgttt catagtttgt aaatcaggta attattatgt taaaattgta gatattaaag
     5941 tatcaagagg gaaaaaatat cttattgtaa aaaatggact taatggattt atgagaccta
     6001 ttatttctaa tttaattgaa aatattactt gtggagtaga attagaaggt caagagccat
     6061 tatatacatc aaatcatgcc ttttctcttt cagtattaaa taatttaaaa gaagaagagt
     6121 atgtaaatgt tgttgggaat ctctgtacat cattagatgt aattgcaaat aatgttaaat
     6181 tgaaaaaagc aaacatagga gatttgattt caattagtaa tgctggaagt tactcctatt
     6241 ctttatcacc gctattattt tcaagttatg aatttcctaa acaatattat aaaagaaaag
     6301 atggatatat tgagtaaaca atagcataaa ttaataaact tagtattatt gaaaaaattt
     6361 aaaatgcagg gggtgtaatt ctatatggaa ttgtggaaaa gaaatttatt tgtatgttgg
     6421 ataggtatgt tttttagttc tatagggatg agccaaatag cacctatact ttcattatat
     6481 attaaacagt tgggggtaac tgatgttagt ttaatacaac agtattcagg tatagttttt
     6541 ggatgtacct ttgtagtagc agcattcttt tcgccaattt gagggaaagc tgctgataaa
     6601 tatggaagaa aatcaatgct tttacgtgca agtattggga tgggaatagt tatatttacc
     6661 atggcgtttg ttcaaaatgt ctatcagtta ttaggattaa gaatacttca aggagttttt
     6721 acgggttatg ctactgcatg tactactctt attgcaacac agacagataa aaatcattca
     6781 ggatgggctt tgggtactct tgcaactgca tcaactactg gctcattaat tggtccaaca
     6841 gtaggaggat atatagaatc aatcttaggt cttaaaagta catttattat aacaggagga
     6901 ttgttgtttg tatcatttat catctctatt ttatttgtag tagataattt taaacctaaa
     6961 gaaataaaag aatcaatttc tatacctaaa gaacaattaa atatattgcc aaataaattt
     7021 ttaattgcat ctatttttgt aaccacattc attactcaac tagctttata ctctatagaa
     7081 ccaattgtaa ccatatatat atcacaactt acaaattttg catcaaatgt agctttaata
     7141 gctggattga cattttctgc atcaggatta gcaaatttat tagcagctca aaaacttgga
     7201 aaaatgtcgg ataaaatagg tcctcaaaaa gtattgttaa tttcactttt atgggctggg
     7261 attatattta taccacaagc ttttgtaaaa actgcatggc aactgatgtt gttgagattt
     7321 ttattagggt tgtcagttgc agggcttaat ccttctgtta acagcttgct taaaaaaatt
     7381 gcaccagaag aatatgtggg aaaaatattt ggatataatg catctgccca gtatataggc
     7441 tgttcatcag gagcattttt agggggacaa atatcagcac atttaggtat tagaacagta
     7501 tttttttcaa caagtttatt gttgtttatg aatgcacttt ggatgtataa atttactgga
     7561 ttgtttatta aagataagac taaataatca tactatttac atttctaatt ttatgatgta
     7621 aaataaatat tttttatgta atttatcata gaattatata aaaaataacc ctatggtaaa
     7681 aattggaaaa tattattatc gacaaaatct ttgacttaaa aactatattg cgatagtatt
     7741 aatttaataa aagtttgaga ggggcgtaag gttatgacaa tttcaaaaat accacaagca
     7801 gaattaaaag ttatgaagtt tatttgggaa aaaaatgata cagtaacatc aaaagaaact
     7861 attgaagcta tggaacgaaa atatggttgg aaacaaacaa ctacattgac acttttatca
     7921 agacttgtta aaaaacattt tttaagtgca gaaaaaatag atagatacac tcattataca
     7981 atagttgttg gacataagga gtatttaagt gttgagacaa aagatttttt aagcaatata
     8041 cacgacaatt ctttacagag tttaatttca gcactacatg atgatgaagt tgttgataaa
     8101 gatatgttgg atttatttga aagtcatttt aaaaatttag aagaagagta attatatcag
     8161 gatagaactc taagaattta attaatctat ggctgaaaac cataaatggt attatttaat
     8221 cagctactca ctattcataa agtaatatta aataggttct ctaattagta aaatgcctaa
     8281 aataattgga atagggagta tcaagttaaa tgataccact tatttaaata agaaatgatt
     8341 tttaaaattt aaaataattt tataacttgt caatattcat taatctaaag tattatttct
     8401 atttaaccat atcaaaatat attttactat ttttaattat tacaatataa acctgtctt
//
LOCUS       DAEHWM010000130         8376 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.133, whole genome shotgun sequence.
ACCESSION   DAEHWM010000130 DAEHWM010000000
VERSION     DAEHWM010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8376)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8376)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8376
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.133"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            97..549
                     /locus_tag="KNP36_003390"
     CDS             97..549
                     /locus_tag="KNP36_003390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HBF0875235.1"
                     /translation="MVLQEKYIFIDKDLKSKEEVLNFIADSAYILGITTNKEALLKDL
                     LKRENEFPTGIKDGFAIPHTKSVNVKEASILYIKTTNELEWKTLDDSKVRYVFSLLAP
                     HKNEGNIHLKTLSKLATCLMEDDFTSEVKNASDASHLVKYITNKMKEE"
     gene            552..860
                     /locus_tag="KNP36_003391"
     CDS             552..860
                     /locus_tag="KNP36_003391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HBF0875236.1"
                     /translation="MKIVAITSCIAGLAHTPMAAKALEQAASKMGHEIKVEQQGAMGR
                     VNTITKEEAQDADFILIASDQTISGMERFDGKKVIKVKIGIALKKPEAVLTKCIEAIS
                     "
     gene            974..2080
                     /locus_tag="KNP36_003392"
     CDS             974..2080
                     /locus_tag="KNP36_003392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIC"
                     /protein_id="HBF0875237.1"
                     /translation="MSKKNKSLLSELKGHLMTGISYMLPLVIGSSLVVAIPKLTALAV
                     GITSLDAYKNVSGFYHILYLMEQVGWTGIGLLNTVLAGFIAFSIGEKPAMGAGFIGGL
                     IASNTNAGFLGAVIAGFFAGYVCKFLKKKIKISGSASGMMPLIIMPLITVGLTGFLMS
                     VVLAGPLGNINTSLNAWVAEMCQNGTNSVVLALILGAMIGFDLGGPVNKAAWMAGNAL
                     LLEGIYLPAILVNCAIVIPPLGYGLATFIRKSKFSNALAETGKGNIVMGIIGITEGAI
                     PFTLTNPLKLVPVNMIGCALGVGLSALLGVHAIMPPVGGLYGFISIGSGWAYLVGAIF
                     GALVIAILSTTLVDFNEDETTENTEFDEIELDIM"
     gene            2155..4833
                     /gene="mngB"
                     /locus_tag="KNP36_003393"
     CDS             2155..4833
                     /gene="mngB"
                     /locus_tag="KNP36_003393"
                     /EC_number="3.2.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannosylglycerate hydrolase"
                     /protein_id="HBF0875238.1"
                     /translation="MKKTKVHVVPHSHWDREWYFTTSRSKIYLMKDFQDILDILEEKE
                     DFKYFTMDAQASLLDDYLKWRPQDKYRIRDLVQRRRLVIGPWYTQTDQLVISGESIIR
                     NLYYGIDRCNEFGEPMRVGYVPDSFGQSAQMPQIYRGFGIDSSLFWRGVSDDMVDTTE
                     FIWKGSDGSKVLAVQIPFGYYYGGNIPEDDSDLKEYLKDIIVKLKVKASTNNVYFPNG
                     FDQAPIRKNLPDILKKANEIDNENEYEISDIENYIDSVRNERNEFTELKGEFLNAKHM
                     RIHKSIFSSRSDLKIMNNKLENYITNVLEPLLTLSYSLGNEYPHLVIKDIWKLMFENA
                     AHDSIGSCNSDTTNEDVYTRYKQARDLSINLLDLHMRLISTQIKNNNEEITLTVFNGF
                     PEVRNEVVEFDTYIPGQDFVIKNKNGKILNYIIKEKEDITNYILTQTIRLNPSKKIYI
                     PKTVYRAKIALSVKDIPPMGYTQLVFELDTKNKCEIETSNCKEIENKYYKITANKNGS
                     LEILDKESNKTYKNQAVIEDNGDDGDSYNYSPPRKDIYVSSLDSVSSVEVLKSNIQEE
                     MILKYSLTIPASLEERAIGKVSVKMPVTMKITLEPKEQIIKFNVNIKNNQALSHRVRV
                     LFNTEIASKFSIADQQFGIIQRPTVLEKDLALWKRDNYSWQEKPITIEPMQSFVTLED
                     GQRGIALITGCVREYQIVGDNLDTIALTLFRSFGYMGRENLLYRPGRASGEKIIATPD
                     AQLLKELNFDFGLYIYNNKFDEANVANTAKRFLTPIQIYEYADFLNGRLIFAFNDEKQ
                     IYENEFSLMNVNNSNFTVSAIKKEEKGDGIVVRIFNGMKNEDAKGSLNINKNVNDAYS
                     AMLDEIYDNTSKLKVNTKTVEVNSLSHCKVQTIVIK"
     gene            complement(5150..7483)
                     /locus_tag="KNP36_003394"
     CDS             complement(5150..7483)
                     /locus_tag="KNP36_003394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0875239.1"
                     /translation="MDTKLKKFKDKYIVTIIVFILMLSASLGMISQYSTIQASAKGGA
                     ENPFEQESFVDSIYKGSYVLYHNMKEEQEGKMIQPSKLFINEETMNYIKNVSKEKDTY
                     DGSETYYTDDSINADFNENFENWEHFIKASGKNLKYYLVDKESNFEFFNDNKELGVLD
                     TTKNDASKENSDENQSKNTEMNDEERQKQITDIKENYRFYVVMNFDKDGKVNIVDSYG
                     VNQKIINQMLLSKAREDLMDTSLGGNSISYKLSPIKNITLVYAVPKVISKGDSVEYGY
                     GNTYFDDGIISYISNVENNSYYKISGMILKIILAIVVIVALAFPYRKSKELLGFDTLS
                     RIPLEILFIALAIIQGLVDLYPTVIISNTLSGNYVEYLINNDISAKMASILVSLMNLT
                     YWFVIFSIIFVFIILLKHILNVGIREYFTKHTVTGMFFVWLKKAGKTVINQIRTINLK
                     EKPNKTIVTILGINLLIIVIMCSMWFFGIILALIYSVVLFKILSDYSKKTIYEYNQLL
                     DVTKKISDGNLDVNMEKDLGFFNPIKDELGNIQTGFKKAVDEEVKSQKMKTELISNVS
                     HDLKTPLTSIITYIDLLKDESITDENRKLYIDTLDRKSQRLQHLIEDLFEVSKANSGD
                     VYLNIVNVDIVSLMKQTLLELDDKLADSSLIVKNNFSNEKIILPLDSQRTFRVFENLI
                     INISKYAMPNSRVYIDILETDNKVNIMLKNMSASEIDFSVDDIMERFVRGDKSRNTEG
                     SGLGLAIAKSFIELQGGKMNISVDGDLFKVTITFNKN"
     gene            complement(7458..8174)
                     /locus_tag="KNP36_003395"
     CDS             complement(7458..8174)
                     /locus_tag="KNP36_003395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875240.1"
                     /translation="MNSYNILVVEDEKEIADAIEIYLLNQGYNVFKGYNGLEGLKVIE
                     NQEIHLAIVDIMMPKMDGITLTMKLRENYNFPVIMLSAKSEEVDKIMGLNIGADDYVT
                     KPFKPLELLARVNSQLRRYTKYLNMVGNKEQKVESDDSVFAIGGLELNENTKEVSIDG
                     KYIKTTPIEFKILSLLMRNAGRVFSADEIYERVWNENAVNTDTVMVHVRNIREKIEID
                     PKNPKYLKVVWGVGYKIEKI"
BASE COUNT         3127 a         1176 c         1160 g         2913 t
ORIGIN      
        1 catgtcgaag tggaaattag ttatatttaa tttaattagg ataatgatta caatataaat
       61 ataagttaag acattatgaa tggagtggaa aaatatatgg tactacaaga aaaatatata
      121 tttatagata aagacttaaa aagcaaagaa gaagtattaa attttattgc agatagtgct
      181 tatatactag gtattacaac taataaagag gctcttttaa aagaccttct aaaaagagaa
      241 aatgaatttc caacaggaat aaaagatgga tttgcgatac ctcatacaaa gagtgtaaat
      301 gtaaaggaag cttccatact ctatattaaa acaactaacg agttagaatg gaaaacttta
      361 gatgatagta aggttagata tgtatttagt ttgttagccc cacataaaaa tgaaggaaat
      421 atacatttga aaactctatc taaattagcc acatgtttaa tggaggatga ttttacaagt
      481 gaagttaaaa atgctagtga tgcaagtcat ttagtaaaat atataactaa taaaatgaag
      541 gaggaataat tatgaaaata gtagctataa catcatgtat agcaggatta gcacacacac
      601 ctatggcagc aaaagcttta gaacaagctg catcaaaaat gggtcatgaa atcaaagtag
      661 aacaacaagg tgctatggga cgagtaaata ctataacaaa agaagaagca caagatgcgg
      721 actttatact tatagcatct gaccaaacta tatctggaat ggaaagattt gatggtaaaa
      781 aagtgataaa agtcaaaata ggtatagcgt taaaaaaacc agaagctgtc ttaacaaagt
      841 gtatagaagc tatttcttaa taaaaaaatc tcactctaat atagaatgag aaaaatcaaa
      901 aattaaaaaa ttgtctaatg taattataac atattatcaa aaaatataac aaacttatat
      961 aggaggatta aaaatgagta aaaaaaataa atctctttta agtgaactta agggacactt
     1021 aatgacaggt atctcatata tgttgccact tgtaataggc tcatctttag ttgtagctat
     1081 cccaaagctt acagctttag cagtgggtat aacaagttta gatgcttata aaaatgtatc
     1141 tggtttttat catattcttt acttaatgga acaagttggt tggactggca taggtctatt
     1201 aaatacggta ttagcaggat ttatagcatt ttcaataggt gagaaaccag ctatgggtgc
     1261 aggttttatt ggtgggctca tagcaagtaa tactaatgca ggattcttag gagcagtaat
     1321 agcaggtttc tttgctgggt atgtttgtaa gtttttaaag aaaaaaatta aaatatctgg
     1381 gtcagcatca ggaatgatgc cacttataat aatgccactt ataacagttg gattaactgg
     1441 ttttttaatg agtgttgtat tagcaggacc tttaggaaac ataaatactt cattaaatgc
     1501 ttgggtagct gaaatgtgtc aaaatggaac aaattcggtg gtattggctt taattttagg
     1561 cgcaatgata ggattcgatt taggtggacc agtaaataaa gcagcttgga tggcaggaaa
     1621 tgcattattg ttagagggaa tctatctacc agcgatattg gtaaactgcg caatagttat
     1681 acctccacta ggatatggtt tagctacatt cataagaaaa tcaaaatttt ccaatgcatt
     1741 agctgaaaca ggaaaaggca atatagttat gggtataatt ggaataacag aaggtgcaat
     1801 tcctttcact ttaacaaatc cattaaaatt agttcctgtt aatatgatag gatgcgcttt
     1861 gggtgtagga ttatcagctt tgttaggtgt acatgctata atgcctccag ttggtggatt
     1921 atatggattt atatcaatag gttctggatg ggcttactta gtaggtgcaa tatttggagc
     1981 tttagtaata gcaatattat caacaacttt agtagacttc aatgaagatg aaactacgga
     2041 aaatacagaa tttgatgaaa tagagttaga tataatgtaa attaaaaact taattttaga
     2101 taattgagaa ttgagtgtac tctcaattct caattaaatt ttgggaggat ttttatgaaa
     2161 aagacaaaag tacatgtagt tccacacagt cattgggata gagaatggta ttttacaaca
     2221 tcaaggtcaa aaatatattt aatgaaagat tttcaagata tattagacat attggaagaa
     2281 aaagaagact ttaaatactt tactatggat gcacaagctt ctctcttaga tgattattta
     2341 aaatggagac ctcaggataa atatagaata agagatttag ttcaaagaag aagattagtt
     2401 attggacctt ggtatactca aacagaccaa ttggttatat caggagaatc tataattaga
     2461 aacctttact atggaataga tagatgcaat gaatttggtg aacctatgag ggttggatat
     2521 gtaccagatt cttttgggca atcagctcaa atgccacaaa tatacagagg ttttggaata
     2581 gatagttcat tattttggcg tggagtttct gatgatatgg tagatacaac agagtttata
     2641 tggaaaggtt ctgatggttc aaaagtatta gcagttcaaa taccatttgg ttattactat
     2701 ggaggtaata taccagaaga tgattcagat ttaaaagaat atttaaaaga tataatcgta
     2761 aaacttaagg ttaaagcttc tactaataac gtatattttc caaatggatt tgaccaagca
     2821 ccaataagaa aaaaccttcc tgatatatta aaaaaagcta atgaaataga taatgaaaat
     2881 gaatacgaaa taagtgatat agaaaactat atagattcag taagaaatga aagaaatgaa
     2941 tttacagagc ttaaaggtga atttttaaat gctaaacata tgagaataca caaatccata
     3001 ttctcctcaa ggtcagacct taaaataatg aataacaaat tagaaaatta tattacaaat
     3061 gtacttgaac cgttattaac attaagttat tcacttggaa atgaataccc tcacctagtt
     3121 ataaaagata tatggaaact tatgtttgaa aatgcagctc atgacagcat aggttcttgt
     3181 aatagtgaca caacaaatga ggatgtatac acaagataca aacaagccag agatttgagt
     3241 ataaatttat tagatttgca tatgagactt ataagtactc aaatcaaaaa taataatgaa
     3301 gaaataacat taacagtatt caatggattc ccagaagtca gaaatgaagt tgtagaattt
     3361 gatacttata ttccaggtca agattttgtg ataaagaata aaaatggaaa aattcttaat
     3421 tatataataa aagaaaaaga agatattaca aattatatat taactcaaac aataagatta
     3481 aacccaagta aaaaaatata tatacccaaa actgtatata gagcaaaaat tgcactttca
     3541 gtaaaagata taccaccaat gggatatact caactagttt ttgaattgga tactaaaaat
     3601 aaatgtgaaa tagaaacaag taattgcaag gaaatagaaa acaaatacta caaaataaca
     3661 gccaataaaa atggttcatt agaaatatta gataaagaat ctaataagac ttataaaaac
     3721 caagctgtaa ttgaagacaa tggagatgat ggagattcat acaactattc tcctccaaga
     3781 aaagatattt atgtttcatc tttagattct gtatcttcag tagaagtgct aaaatcaaac
     3841 attcaagaag aaatgatact taaatattca ttgaccatac cagcttcact ggaagaaagg
     3901 gctataggta aagtttctgt gaaaatgcca gtaacaatga aaatcacctt agaacctaaa
     3961 gaacaaataa ttaagtttaa tgttaatata aaaaataacc aagcactatc tcatagagta
     4021 agagttttat ttaatacaga aatagcatct aagttttcta tagcagatca acaatttgga
     4081 ataatacaaa gaccaacagt attagaaaaa gaccttgcat tgtggaaaag agacaattac
     4141 tcatggcaag aaaaacctat aactatcgaa ccaatgcaaa gttttgttac tttagaggat
     4201 ggacaaagag gaatagcatt aataactggt tgtgtaagag aatatcaaat agttggtgat
     4261 aatttagata caatagcatt aacactattc aggtcatttg gatatatggg aagagaaaat
     4321 ttactttata gaccaggaag agcttctgga gaaaaaataa tagcaacacc agatgcacaa
     4381 ttacttaaag agttaaactt tgactttggt ctttacatat ataacaataa atttgatgaa
     4441 gcaaatgtag ctaatacagc taagagattc ttaacaccta tacaaatata tgaatatgct
     4501 gattttttaa atggtagact tatatttgca ttcaatgacg aaaaacaaat atatgaaaat
     4561 gaatttagtt tgatgaatgt aaataattca aatttcacag taagtgcaat aaagaaagaa
     4621 gaaaaaggag atggaattgt agttagaatc ttcaatggta tgaaaaatga ggatgctaag
     4681 ggaagtctta acatcaataa aaatgtcaat gatgcttata gtgcaatgct cgacgaaatc
     4741 tatgataata ctagcaagct taaagtaaat actaaaactg tagaggtaaa ttctttatca
     4801 cattgtaaag tacaaacaat agtaattaaa taatataaaa tagcttatac aagatttcaa
     4861 aataaattgc tagtaccatg ttaatagtaa agccagatat tatgctattt ataagctctg
     4921 taacactaaa taacattttg taaaataaaa aggtgaacct tgtatattag gattcacctt
     4981 ttttaaataa atcaacattc tgttttaaaa taacatttat aagctgtttt gaaataatgc
     5041 ttacaaatta ttttaaaaca atacctataa atttttattt aaagaataca cataaatatt
     5101 tccagactct tttatcctat agactttata attattaaag aagtctaatc taatttttgt
     5161 taaaagtaat tgtaacttta aataaatcac catccacact tatattcatc ttaccaccct
     5221 gtaattctat aaaacttttt gctatcgcta aaccaagacc agaaccttct gtgttacgtg
     5281 atttatctcc tcttacaaat ctctccatta tatcatctac actaaaatca atctcagatg
     5341 cagacatatt tttaagcata atatttactt tattatctgt ttctaaaata tcaatataca
     5401 ctcttgaatt tggcattgca tatttgctta tatttattat aagattttca aatactctaa
     5461 atgtacgctg actatctaat ggtaatatta ttttttcatt agaaaagtta ttctttacta
     5521 ttagagatga atctgcaagt ttgtcatcta attctaaaag tgtctgcttc attagagata
     5581 caatatccac atttactata ttcaaataaa catctccact atttgccttg cttacttcaa
     5641 acaaatcttc tattagatgt tgcaatcttt gtgactttct gtctaatgta tcaatataca
     5701 acttacgatt ttcatctgtt atactttcat cttttaataa atctatataa gtgattatag
     5761 atgttagagg tgtttttaag tcatgtgata catttgatat aagctctgtt ttcatctttt
     5821 gactcttaac ctcttcgtca acagcttttt taaatccagt ttgaatattt cctaattcgt
     5881 cttttatagg attaaaaaat cctaaatctt tttccatatt tacatctaag tttccatctg
     5941 aaattttctt tgtaacatct aaaagttgat tatattcata tattgtcttt ttagagtaat
     6001 ctgacagtat tttaaataat actactgaat atattaatgc gagtattatt ccaaagaacc
     6061 acatactaca cattataact ataatcaata aatttattcc caaaattgta actatagttt
     6121 tatttggctt ttcttttaga tttattgttc taatttgatt aataactgtt tttcctgctt
     6181 tttttagcca tacaaaaaac attcctgtca cagtatgttt tgtaaaatac tctcttattc
     6241 caacatttaa aatatgtttt aaaagtatta taaatacaaa tattattgag aatattacaa
     6301 accaataagt taaattcatt aaacttacca atatactagc cattttagca cttatgtcat
     6361 tgtttataag gtactctaca taattcccac tcaaggtatt acttattata acagtaggat
     6421 ataaatctac aagcccctgt ataatagcaa gagcaataaa gagtatctct aacggtattc
     6481 ttgataatgt atcaaatcct agcaactctt tagattttct atatgggaat gctaaagcta
     6541 caataacaac tatagctaat ataattttta aaatcattcc agaaatctta taataagaat
     6601 tattttctac attgcttata tatgaaatta taccatcatc aaaataagta tttccataac
     6661 catactctac actatcacct ttacttatta ctttaggtac agcatatact aatgttatat
     6721 tttttattgg agataactta tatgaaattg aatttcctcc taaacttgta tccattaaat
     6781 cttctcttgc tttagataac aacatttgat taataatttt ttgatttact ccataagaat
     6841 ccacaatatt tacttttcca tctttatcaa aattcattac aacgtagaat ctatagtttt
     6901 cttttatatc tgtaatctgc ttttgtcttt cctcatcatt catttctgta ttttttgact
     6961 gattttcatc agaattttct tttgaagcat cattttttgt tgtatcaagt actcctaatt
     7021 ctttattatc attaaaaaat tcaaaattgc tttctttatc aactaaatag tactttaaat
     7081 tctttcctga cgctttaatg aaatgctccc aattttcaaa gttttcatta aaatctgcat
     7141 taatactatc atctgtatag taagtttctg aaccatcata agtatctttt tctttactta
     7201 cattttttat atagttcata gtttcttcat tgataaatag ttttgatggt tgtatcatct
     7261 taccttcttg ttcttccttc atattatgat ataaaacata acttccttta tatatactat
     7321 ctacaaagct ttcctgttca aatggattct ctgctccacc tttagcactt gcttgtatag
     7381 tagaatattg actaatcata cctaatgatg ctgataacat aagtataaaa actataatag
     7441 taactatata tttatcttta aattttttca attttgtatc caacacccca caccaccttt
     7501 aaatatttag gattttttgg gtcaatttct atcttttccc ttatattcct cacatgtacc
     7561 ataactgtat ctgtatttac agcattctca ttccaaactc tttcatatat ttcatcagca
     7621 gaaaaaactc ttcctgcatt tctcataagt aaacttagta ttttaaattc tataggagtt
     7681 gtttttatat actttccatc aatactaact tcttttgtat tttcatttaa ttctaatccg
     7741 cctattgcaa acacactatc gtcactttct accttttgct ctttatttcc aaccatgttt
     7801 agatacttag tgtaccttct aagttgtgaa ttaactctag ccaatagttc taatggctta
     7861 aaaggttttg ttacataatc gtctgctcct atattaagcc ccattatttt gtcaacttcc
     7921 tctgattttg cagatagcat tattactgga aaattatagt tttctctaag cttcattgta
     7981 agtgttatac catccatttt aggcatcatt atatcaacta tagctaaatg tatttcttgg
     8041 ttttctataa ccttaagacc ttctaatcca ttgtatccct taaaaacatt atatccttga
     8101 tttaatagat atatttctat agcatctgct atctcctttt catcttctac caccaaaata
     8161 ttatatgaat tcattctaat ctcctttata ttaatttata aattttcttt acatatatga
     8221 ttatacaata tgatagaagt ttttccattt atatatatat ttatatcttt tgttctggtt
     8281 atttgtattt aatgtccatc ttagaaacct ccttctagtt taaatttaat attttttcat
     8341 tttgttttat atacttaata ttaaaattaa aaactt
//
LOCUS       DAEHWM010000131         8116 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.134, whole genome shotgun sequence.
ACCESSION   DAEHWM010000131 DAEHWM010000000
VERSION     DAEHWM010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8116)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8116)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8116
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.134"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(271..1542)
                     /gene="sleC"
                     /locus_tag="KNP36_003396"
     CDS             complement(271..1542)
                     /gene="sleC"
                     /locus_tag="KNP36_003396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore cortex-lytic protein SleC"
                     /protein_id="HBF0875241.1"
                     /translation="MQDGFLTVSIIDATNNRPIQNAVVNIYSMSNGSQSSSTLYQNLR
                     SNESGQVTGLVLPAPDVDYSLQPSDVRPYSQYIVEAIADGYETVVIEGTQLLATIEAR
                     QGVPMSPRTRSKRSFSRQSELIFDIGEHTLYGTYPPKIPESNLKPLPPPTGFVVLDNP
                     VVPEFIVVHDGLPEDSSAPNYWIPFKEYIKNIASSEIYSTWPEQTIYANVIAIISFTL
                     NRVFTEWYRNKGYNFTITSTTAYDHKFINNRNLFEPINVVVDAIFNTFIKRPPTSRQP
                     LLAQYCDGQKSQCPDQMTQWGSKDLGDQGYDYESILRYFYGDEIVFERAPIVSGVPVS
                     FPGTTLQVGSSGQYVRTIQNQLNAISNSYPAVPKVIEDGIYGTDTENAVKIFQGIFGL
                     PQSGVVDFKTWYEISRVYVATTRIASLNPLI"
     gene            1787..2503
                     /locus_tag="KNP36_003397"
     CDS             1787..2503
                     /locus_tag="KNP36_003397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HBF0875242.1"
                     /translation="MKLDLFLLAIIPILIGMFWIRSKDRYCREPLIHLIKFFLIGAFL
                     SVIIILLENLLMKFNVFEGYSELIYVSFVVAGLVEEGVKALILIPALIKEKHFTEKLD
                     GIIYSVFLALGFATIENMVYIFSESRNLALQVGINRAVISIPAHVMFAITMGYYISKY
                     KFEGNKNKRREYLFMAVLIPILLHGVFDFILMIEYRWAIILLIVYVIILWKINLDKLE
                     KYMNHSKKVFFGNLRKKKKK"
     gene            2582..3892
                     /locus_tag="KNP36_003398"
     CDS             2582..3892
                     /locus_tag="KNP36_003398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmB/NOP family class I SAM-dependent RNA
                     methyltransferase"
                     /protein_id="HBF0875243.1"
                     /translation="MTELPKEFLEDIEEILKDEYDDFIKSYEESKTTGLRINTLKIDK
                     KKLFDLELFDLNQIPWAEEGFYYDDKIDRPGRNPLHEAGAYYLQEPSAMSVIPKADIK
                     EGEKVLDMCAAPGGKSTYILSKLNDTGLLVSNEINASRIKALGENLERFGARNCIITN
                     TDSNSLRKTFNGYFDKVIIDAPCSGQGMFRKDEVAISDWSYAKVVECQSIQKEIIRDG
                     YKMLKKDGILIYSTCTFSREENEHVINEFISEYPHAELIEMERLWPHKIKGEGHFVAK
                     IKKLEEEECNVKELKIKNLDKEIKDYREFEKKFLKVDFYSNKKNKFYLRGENLYLLPE
                     IYPDTKKLKVLRYGLHLGVLKKNRFEPSHALSHYLKVEDVKNVENFSVQSESILKYLK
                     GDVVNSNDSRGWVLVSVEGIPLGWGKESSGVIKNHYPKGLRKVF"
     gene            3992..4528
                     /gene="lepB"
                     /locus_tag="KNP36_003399"
     CDS             3992..4528
                     /gene="lepB"
                     /locus_tag="KNP36_003399"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBF0875244.1"
                     /translation="MGEAVKKEVVEWIKVIVIALVLAFAITRFIVPTIVKGESMYPTL
                     VERDYLIVNRIAYKVGEPKYKDIIVFKTDLTEENGKKKDLVKRVIGVPGDHVKIQDSK
                     VYVNDKLLDETSYIHNNRTDGDIDIVVPEGKLFAMGDNREKSLDSRYDEVGLVDEHTI
                     LGKVLVRLYPFSKIGTID"
     gene            4694..5230
                     /gene="lepB"
                     /locus_tag="KNP36_003400"
     CDS             4694..5230
                     /gene="lepB"
                     /locus_tag="KNP36_003400"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HBF0875245.1"
                     /translation="MNETIKEEIVEWIKIIITALFFAFIITRFIKPTLVNGESMYPTL
                     KSHDYLVANRMTYKLSEPKCGDIMIFKTDLLQENGRKKELVKRVIGVPGDHLKIKDSK
                     VYINGKLLNEVSYIHDNYTEGDIDMVIPKGKVFAMGDNREVSLDSRYKEVGLVDEENI
                     KGKVILRVFPFTDIGIFE"
     gene            5240..5995
                     /locus_tag="KNP36_003401"
     CDS             5240..5995
                     /locus_tag="KNP36_003401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIM barrel protein"
                     /protein_id="HBF0875246.1"
                     /translation="MAVGIASLLFNIEEALNICESIKQITHLEIGIDNISECSELCKY
                     KERISKLGLSIGIHLPMELNTCENIEYIRNSWINFIEKIEFELKGFDLRYFNLHLGYV
                     MTNRVRKNRDKYLGNSVDFLDKLNTNSYVCIENTYSKGGDFSNIGNISYDFEYIFKRI
                     KNSKICFCYDTGHCLIDEDAYVKNLKDKIRLIHLSDNDGINDTHVGIGRGILSEEGIK
                     EILTLDAEYLVLEINYEDIEDTISKLNNIVGEG"
     gene            6069..7736
                     /locus_tag="KNP36_003402"
     CDS             6069..7736
                     /locus_tag="KNP36_003402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside kinase"
                     /protein_id="HBF0875247.1"
                     /translation="MKKINLKIEGKDKEYSLEENSPGIRLGDIAKEFCDEHKGYITLA
                     VVDNKLKELNCRVKKDCEINFLDTTNEDGERVYFRVMSFIFVMACREIFWDSRVTIEH
                     SLSDGLYCEVHIDRKLKEADVENIKNKMKEIVNNDYVIEKIEVTRNEAISIFENNEMY
                     EKAELLKYKEYDSAKVYKCRNYIDHFYGYMLPSTGYIKSFDIKLYNGGVIILGPSEED
                     KTLPMKFVPQPKLSSVYYEAEEWSRLMGIDKVVSLNKIIENNEYGDIIRTFEALHEKK
                     LSQIADMIKDGNKRVVLIAAPSSSGKTSFAHRLSIHLRVNNLNPISISLDDYFIDRKH
                     TPLDEYGNYDFESIYAIDLEKFNLDLKKLLAGEEIDDIRFNFKEGKREYTGKKIKIDS
                     NQPIILEGIHGLNPILTSSIPDEDKFKIYISALTQINLDDHNRIPTADLRMIRRIVRD
                     YNFRGYSADNTILQWASVRRGEKKNIFPYQEEADAIFNSACVYELAVLKRFAKPLLEE
                     IKEDNPAHIEATRLLKFLQYFVELDDTSDIPGISILREFIGGSKIVD"
BASE COUNT         3045 a          847 c         1511 g         2713 t
ORIGIN      
        1 ggtttttcgt tagaatagca ttttattaaa cttaaaaata aatataatat tttaaagaaa
       61 tctaagttgc taagcactgt ttttaagaag cttaaaatcc cccatttaaa gttttaagat
      121 tctaaaaaaa caagttataa ctaaaaaatg gctgttaaga ctacaatact tataagtaat
      181 acttatggta tatattagtt cataacagcc acttttattt taaattaata attttattca
      241 ataatttgag tttatgttct aaatcaagct ttaaattaaa ggatttaaag aagctattct
      301 agttgtagct acataaactc tggatatttc ataccatgtt ttaaaatcta ctactccgct
      361 ttgaggtaaa ccaaagattc cttggaatat cttaacagcg ttttctgtat ctgttccata
      421 gataccatct tctataactt ttggtacagc tggataagaa ttagatatag catttaactg
      481 attttgtatg gttctaacat actgcccaga agaaccaact tgtagtgtag taccagggaa
      541 tgacactggt acaccactta ctataggtgc tctttcaaat actatctcat ctccatagaa
      601 atatcttagt atactctcat agtcatatcc ttggtcacct aagtctttac tgccccattg
      661 agtcatttgg tcaggacatt gggatttttg tccatcacaa tattgtgcta atagtggctg
      721 tcttgatgta ggaggtcttt ttataaaagt attaaaaata gcatctacaa ctacgttaat
      781 tggttcaaat aagtttctat tatttataaa cttatggtcg tatgctgttg ttgaagttat
      841 tgtaaagtta tatcctttat ttctatacca ttcagtaaag actctattta aagtaaatga
      901 tattatagct attacatttg catagattgt ctgttcaggc caagttgaat atatttcaga
      961 tgacgctatg tttttaatgt actctttaaa tggaatccaa tagtttggag ctgatgaatc
     1021 ttctggcaaa ccatcatgaa ctactataaa ttcaggcact acggggttat ctaatacaac
     1081 gaaaccagta ggaggtggta atggttttaa gttactttct ggaatcttag gaggataagt
     1141 accatataga gtatgttctc ctatatcaaa aatcaactca ctttgtcttg agaaagaacg
     1201 cttacttctt gttctaggag acatgggaac tccttgtctt gcttcaattg tagctaacaa
     1261 ctgtgttcct tctatgacaa ctgtctcata tccatctgct atggcttcca ctatatactg
     1321 gctataaggt ctaacatcag atggttgtag agagtaatct acatctggtg ctggtaatac
     1381 taaaccagtc acttgaccag attcattact tcttaggttt tggtataaag ttgatgagct
     1441 ttggctacca ttagacattg aatatatgtt tactactgca ttttgaatag gtctattgtt
     1501 agtagcatca attatgctta ctgttaagaa accatcttgc atcaaatcac cctttcttta
     1561 aatgaattta gttcccttat atttcaagat atgaatatag cttgaaattt gttaaataat
     1621 atagatataa atttaaattt ttttgagtat ttgagtatat ttgtatttaa ataatttaaa
     1681 ataatttaat gtatatttta gtatgtattt aaaacacgaa taagttaaaa ataagtagat
     1741 gatataaatc ataaataaat caaaaatttt gaaaggaaaa taatctatga agctagattt
     1801 atttttatta gcaataattc ctatattgat agggatgttt tggataaggt ctaaagatag
     1861 atattgtaga gaacccctaa tccatctaat taaatttttt ttaataggtg cttttctaag
     1921 tgttataatt atacttttag aaaatttact gatgaagttt aatgtatttg aagggtattc
     1981 agaactaata tatgtatcat ttgtagttgc aggacttgta gaagaaggtg taaaagctct
     2041 gatactgatt cctgccctaa ttaaagaaaa acactttact gaaaagttag atggtattat
     2101 ttactctgta tttttagctt taggatttgc aacaattgaa aatatggttt atattttttc
     2161 tgaaagtaga aatctagcac tgcaagttgg tattaatagg gcagttatct ctataccagc
     2221 tcatgtaatg tttgcaatta ctatgggcta ctatatttct aagtataaat ttgagggaaa
     2281 taaaaataaa agacgtgagt atttgtttat ggcggtgtta attccaattt tattacatgg
     2341 agtttttgat ttcatattga tgatagaata tagatgggct attatattac ttatagttta
     2401 tgtaataatt ttgtggaaga taaatcttga taaacttgag aaatatatga atcactctaa
     2461 aaaagtgttt ttcggtaatc ttaggaaaaa gaagaagaaa taaaatttaa aggaaagaca
     2521 taaataatta aagtataata aatgacacac aagtaaagca gattgaaggg ggattataga
     2581 tttgacagaa ttaccaaagg aatttttaga agatattgaa gaaatactaa aagatgaata
     2641 tgatgatttt ataaaaagtt atgaggaaag taagactact gggcttagaa taaatacttt
     2701 aaaaattgac aagaaaaaat tatttgattt ggagttgttt gatttgaatc aaataccatg
     2761 ggcagaagaa ggtttttatt atgatgataa aattgacaga cctggtagaa atccactgca
     2821 tgaggctgga gcatactatt tgcaagagcc ttctgcaatg agtgtaatac caaaggcaga
     2881 tattaaagag ggtgaaaaag ttctcgatat gtgtgctgct cctggtggaa aatctacata
     2941 tatactatct aagctaaacg atacaggttt attggtttct aatgaaatta atgctagtag
     3001 aattaaggct ctaggggaaa atttagagcg atttggagcg agaaattgta ttataacaaa
     3061 caccgattct aatagcttaa gaaagacgtt taatgggtat tttgataagg ttattataga
     3121 tgcaccttgt tctgggcaag gtatgtttag gaaggatgag gttgccatat cagattggag
     3181 ttatgcaaag gtagtagaat gtcaatccat ccaaaaagag attataagag atggatataa
     3241 aatgttaaag aaggatggca ttttaattta ctcaacttgt actttttcaa gggaggaaaa
     3301 tgagcatgtt ataaatgagt ttatcagtga atatccacat gcagaactta ttgaaatgga
     3361 aagattatgg cctcataaga taaagggaga aggtcatttt gttgccaaaa taaaaaaatt
     3421 agaagaagaa gaatgtaatg tcaaagaatt aaaaataaaa aatttagata aagaaataaa
     3481 ggattatagg gagtttgaaa agaaattttt aaaggttgat ttttatagta ataaaaaaaa
     3541 taaattttat ttaagaggag aaaatttgta cctacttcct gaaatatatc cagatacgaa
     3601 aaaactaaaa gtattgagat atggtttgca tttaggggtt ttaaagaaga atagatttga
     3661 gccttctcat gcactatctc attacttaaa agttgaagat gtaaaaaatg ttgaaaactt
     3721 cagtgtacag agtgaatcaa ttcttaaata tttaaaaggg gatgttgtaa attctaatga
     3781 tagtagagga tgggttttgg tttcggttga aggaatacct ttaggttggg gaaaagaatc
     3841 ttctggtgta attaagaatc attatcctaa aggtcttaga aaagtatttt aaactattag
     3901 aaaaaagaag tataatattt atattgtagg tttatggtag attattttgc tgtagattga
     3961 cttaatattt aacacagagg agacgatttt agtgggtgaa gcagttaaaa aagaagttgt
     4021 agaatggata aaagtgattg tcatagctct tgttttggca tttgcaataa ctcgttttat
     4081 agtgccaaca atagtcaaag gagaatcaat gtatcctaca ttagttgaac gtgattattt
     4141 gatagttaac agaattgcgt acaaggtagg agagccaaaa tacaaagata taatagtatt
     4201 caaaaccgac ttaacagagg aaaatggaaa gaaaaaagat ttagtaaaaa gagttatcgg
     4261 ggttcctggt gaccatgtaa aaatacaaga ctccaaggta tatgtaaatg ataagttgtt
     4321 agatgagact tcctatatac ataataatcg tactgatgga gatattgata tcgtagttcc
     4381 agaaggaaaa ttatttgcaa tgggagataa tagagaaaaa agtttagata gtagatacga
     4441 tgaggttgga ttggtcgacg agcataccat tttaggaaag gttctagtca gattgtatcc
     4501 attttctaag ataggaacta ttgactaaac atataaaatt tggagcaatc gctgattagc
     4561 tgaaatcacc agaccataca caatagttgt ctatataaaa aagacaacac cttatttagt
     4621 agacttatct aaaagatagt gtttaagaga cattatcaat aaagataata taactataaa
     4681 ggagaatttg tgaatgaatg aaactattaa agaagagatt gtagagtgga taaaaataat
     4741 tattactgca cttttttttg catttattat aactcgtttt ataaaaccaa cattagtaaa
     4801 tggagaatca atgtacccaa cacttaaatc acatgattat ttggtagcaa acaggatgac
     4861 atataagtta tcagaaccaa aatgtggaga tataatgata tttaagactg atttattaca
     4921 agagaatgga aggaaaaaag agcttgtaaa aagggttata ggtgttcctg gtgaccatct
     4981 aaaaattaag gattctaagg tttatataaa tggtaagtta ttaaatgaag tttcatatat
     5041 acatgataat tatactgaag gcgatattga tatggtgatt cctaagggaa aagtatttgc
     5101 gatgggagac aatagagaag ttagtttaga cagtagatat aaagaagtgg gattagtaga
     5161 tgaagaaaat attaaaggaa aagttatttt aagagtattt ccttttacag atataggtat
     5221 ttttgagtag gtgatttgta tggcagttgg tatagcgtcc ttattgttta atattgagga
     5281 ggctttaaac atttgtgaga gtataaagca aataactcat ttagagattg gaattgacaa
     5341 tatatctgaa tgtagtgagt tatgtaaata taaagagaga atttctaagt taggattatc
     5401 tatagggata catttgccta tggaattaaa tacttgcgaa aacatagagt atatacgaaa
     5461 ttcatggata aattttattg agaagataga atttgaacta aaaggatttg atttaaggta
     5521 ttttaacctt catttgggat atgttatgac aaatagagtt agaaagaata gagacaaata
     5581 tttaggaaat agtgtggatt ttttagataa attaaataca aattcatatg tatgtataga
     5641 gaatacttat tcaaaaggtg gggatttttc aaatattgga aatatatctt atgattttga
     5701 atatatattt aagaggatta aaaattctaa gatttgtttt tgttacgata ctggacactg
     5761 tttaattgat gaggatgctt atgtaaagaa cttaaaggat aaaataagac tgatacactt
     5821 aagtgataat gatggtatca atgatacaca tgttggtata ggaagaggaa ttttatctga
     5881 agaggggatt aaagagatct taacattaga tgcagaatat ttagtattag aaataaatta
     5941 cgaagacatt gaagatacta taagtaaatt gaataatatt gtaggagagg gttaaatacc
     6001 tctctttatc ttgttgatat gcctcattaa ttaaaattta tattcatcaa aaggaaggag
     6061 atgttgaagt gaaaaaaata aacttaaaaa tagaaggaaa agataaggaa tattcattag
     6121 aagaaaattc ccctggaatc agattgggag atatagcaaa agaattttgt gatgagcata
     6181 agggttatat aacacttgca gttgtagaca ataaactaaa agagctaaat tgtagagtta
     6241 agaaggattg tgagataaat tttttagata ctactaatga agatggagag agagtttact
     6301 ttagagtcat gtcatttata tttgtaatgg catgtagaga aatcttttgg gatagcagag
     6361 ttacaataga acattcacta tcagatgggc tatattgtga agttcatata gatagaaagc
     6421 ttaaagaagc agatgttgaa aatataaaaa acaagatgaa agagatagta aacaacgatt
     6481 atgttataga aaaaattgaa gttacaagaa atgaagctat ttctatcttt gaaaataatg
     6541 aaatgtatga aaaggcagag cttttgaaat acaaagagta tgatagtgct aaagtatata
     6601 agtgtagaaa ctatatagac catttttatg gttatatgtt gccatcaact ggttatataa
     6661 aatcatttga tattaagctt tataatggag gcgttataat tttaggacct agtgaagaag
     6721 ataagactct tcctatgaaa tttgtacctc aacctaagct atcaagtgta tattatgaag
     6781 cagaagaatg gtcaagactt atgggaattg acaaggtagt atctcttaat aaaataatag
     6841 aaaacaatga atatggagat ataataagga catttgaagc attgcatgaa aagaagttat
     6901 cccaaatagc ggatatgata aaggatggca ataagagagt agttttaata gcagctccat
     6961 cttcatctgg aaaaacaagt tttgctcaca gattatcaat acatcttaga gtaaataatt
     7021 taaatcctat ttcaatttct ttagatgatt attttataga tagaaaacat actcctttag
     7081 atgaatatgg aaattatgat tttgaatcaa tttatgcaat agatttagag aagtttaact
     7141 tagacttaaa gaaactttta gctggtgaag aaattgatga tataagattc aattttaaag
     7201 aaggtaagag agaatacact ggtaaaaaga taaagataga ttcaaatcag ccaattatat
     7261 tagaaggtat acatgggcta aatcctattt taacatcatc tataccagat gaagataaat
     7321 ttaagatata cataagtgcc cttactcaaa taaatttgga tgaccataat cgaatcccta
     7381 ctgctgattt gagaatgata agaagaattg ttagagacta taattttaga ggatatagtg
     7441 ctgataatac tattttacaa tgggcatcag ttagaagagg agaaaagaag aatatattcc
     7501 cgtaccaaga ggaggcagat gctatattta actctgcttg tgtatatgaa ttggcagttt
     7561 taaaacgatt tgcgaaacct ttgttggaag agataaagga agataatcct gcacatattg
     7621 aagctactag attactaaag tttttgcagt attttgttga attggacgat acttctgaca
     7681 taccaggtat ttcaattctt agggaattta ttggaggaag taaaatagtt gattaatgtg
     7741 tgtattatag attgttttat gaagattaaa tggcatagca agtagtgtta ttggtttatg
     7801 ttaagtatat taagtgtaaa gtggagaatt aaattgatac agattttaaa gtttgagttg
     7861 atatataaaa aggcttgttt tatacttttg tatgaagcaa gctttttatt ttaaatttta
     7921 cttttttgtt taatattttg ttaatttatg tgattatttt ttaaaagagt aaaagagtaa
     7981 aagagtaaaa gagtaaaaga gtaaaagagt aaaagagtaa aagagtaaaa gagtaaaaga
     8041 gtaaaaggtg ttgggttaga aatttttggt gttataaaaa tttaaattac tggattatta
     8101 gattgctgga ttgcta
//
LOCUS       DAEHWM010000132         8087 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.135, whole genome shotgun sequence.
ACCESSION   DAEHWM010000132 DAEHWM010000000
VERSION     DAEHWM010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 8087)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8087)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8087
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.135"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            90..2324
                     /locus_tag="KNP36_003403"
     CDS             90..2324
                     /locus_tag="KNP36_003403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /protein_id="HBF0875248.1"
                     /translation="MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNRE
                     FMYQHIDDCISKNIHIGIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKG
                     IVAYLKGEGFLIVLPNVSNKELNNMGATIIESARELKIRLPNEKEIYSNVTFSIGSTI
                     WNGEPNMTTLMLFNQVYSALKKAKSEGKNRYILFDFKDNSFYNKLENDKEFLSEISHV
                     LQTKQIEVFYQPLYNIKNNTIVGCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDL
                     HLFEENCKNIRRWIDNNDVFVPICCNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIE
                     ITENILIENTNTIIQQLAELRSYGFSVSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLS
                     HNLNDFKNTTILYSIINIARALGMLTVCEGVETEQHVEFIKSINCDIAQGYYYAKPME
                     CKEFEKLLSKENNSEKMFIKYSDIGKSLIEKIFDGFFIMQDMKKLRANVTEDIQWFDF
                     YNKTEITSFPKVIEHFEKHIKGKKFSILYKSITPHNTESDSLLISGEAVLSDEASEHQ
                     KYSNFYFSANCIISENKLLLAKLHLDLIKTAGYINEFESYSIPKMTNTHLDESNILSQ
                     FYSMLPVGIIRYDLFGDMIITYMNEEMFDIIGYTKEQFFGEMGGNLRAIVHPDDLDFV
                     YKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLSAIDGRSIAQGMYVDVNKIKN
                     LTKI"
     gene            2355..3200
                     /locus_tag="KNP36_003404"
     CDS             2355..3200
                     /locus_tag="KNP36_003404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0875249.1"
                     /translation="MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLG
                     MTNIEIAKKLPDNIAKFFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYK
                     VDVDEKTYIITMANDITKLYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVL
                     IDLDNFKMINDYEGHNVGDKILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKN
                     YVYSQLEALRENFLKVFSKYKYLSFSYGVDTVKRNLKLTIVELDKKMYKNKEKNKKKF
                     DKNDY"
     gene            3440..5173
                     /locus_tag="KNP36_003405"
     CDS             3440..5173
                     /locus_tag="KNP36_003405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diguanylate cyclase"
                     /protein_id="HBF0875250.1"
                     /translation="MSILLKKAPKLAKHIITSFYINRDINEVLKYLCENVTWIGPGEQ
                     EFLTSFNEIKNYFYAGQDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENAQMIL
                     EVNQRCTFEIIEDRGKLLIKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTE
                     VIEMITNNINGGLKGSNDDSTYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPD
                     LPKALEDCERCFAKGPTYSSEYRIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDIT
                     QLKNIESELKLERERYRIALQNITDIMFEYDIENDTLIKYQRVEIDKKIELENFETKN
                     YSKLLESGKIIHLDDIGKLLEVLHGNLRETIEIRQVNSLTKNEWRWIRVQCSVIYDSD
                     HNPIKTIGVLKDITEDKSKLESLINQAQRDPLTQLYNQRVSQNLIEEYLCSSDSKNND
                     ALLVIDIDDFKTVNDTFGHLEGNEVLVAVSKILLHNTHDKDIVARIGGDEFTIFIKSL
                     TKDLIIKITNDILNDASKIKVKDNHKITLSIGIAFTDDSTKLYKDLFSKADKALYLSK
                     ADGKNCYSTYE"
     repeat_region   5505..5985
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=5571..5593
                     /rpt_unit_seq="ataccacttagttaatataaaac"
     gene            complement(6515..6619)
                     /locus_tag="KNP36_003406"
     CDS             complement(6515..6619)
                     /locus_tag="KNP36_003406"
                     /inference="COORDINATES: protein motif:HMM:NF024729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HBF0875251.1"
                     /translation="MDDYIYYYNNFRYQNRLNSMSPFEFRKYLSTERA"
     gene            7244..7489
                     /locus_tag="KNP36_003407"
     CDS             7244..7489
                     /locus_tag="KNP36_003407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875252.1"
                     /translation="MNQKKIKISIKMVIIGIFSVIIAFVLSRLFVEYIDELLRSNWQY
                     QLFESESSYIIFANCIMFSNILLEIFLIYICRKFRKI"
BASE COUNT         3214 a          970 c         1056 g         2847 t
ORIGIN      
        1 catttaaatt atttacaaat taacatttaa atacttctag cataaataca gttgtcatca
       61 aaatttaaag tatcttatgg aggaatacca tgcaaaatca taattatata aaaatgttaa
      121 ataaaaaggt agaagtatta tctaaggaat tagatagtag aaattttaaa ttaaaaacct
      181 taaatgaaat agattttttt tctaaaatac caaacagaga atttatgtac caacatattg
      241 atgactgtat ttcgaaaaat atacatatag gaatcatgtt attaaatatc gataacttta
      301 aattatttaa tgatatatat ggatacctag tcggagaaaa tttattaatt actctaactc
      361 aaaacctatt gcactttatt ccagaatcaa agggaatagt cgcttattta aaaggagaag
      421 gttttttaat tgtacttcca aatgtatcaa ataaagagtt aaataatatg ggtgcaacta
      481 ttatagagag cgcccgagaa ttaaaaataa gacttcctaa tgaaaaagaa atatactcca
      541 atgttacatt tagtatcggc agcactatct ggaatggtga accaaacatg actactttga
      601 tgcttttcaa ccaagtgtat agtgctttaa aaaaggctaa aagtgaaggt aaaaatagat
      661 acattctatt tgattttaaa gataatagtt tttacaataa attagaaaat gataaggagt
      721 tcttatcaga aatatcacat gttctacaaa ctaaacaaat tgaagtattt taccaaccac
      781 tttataatat aaaaaataat actatagttg gatgtgaggc acttgcaaga tggagacacc
      841 ctattaaagg acttcttact ccagataaat ttattccttt atttgaacag tttggtctga
      901 taacggaatt agatttgcat ttatttgaag agaactgtaa aaatataaga agatggattg
      961 ataacaatga tgtttttgtt ccaatttgtt gtaacttttc tcgtcttcat ttttttaacc
     1021 ctaattttcc aagtatgcta aaaggtatta ctgaaaagta cagcgtctct acatcaaatt
     1081 ttagcattga aataacagaa aatatattaa tagaaaatac aaatacaatt attcaacaac
     1141 tagctgaact tcgttcttat ggtttttctg tatcaatgga cgattttggt tctggatatt
     1201 catcttttgg tatgttgcaa aatctacctt ttgatataat caaaattgat aggatatttt
     1261 tatctcataa tttaaatgat tttaaaaata caaccatttt gtactctata ataaacattg
     1321 caagagctct tgggatgctt acagtatgtg aaggtgttga aacagaacaa catgtagaat
     1381 ttattaaaag tataaattgt gatatcgccc aaggttatta ttatgcaaaa cccatggagt
     1441 gcaaagaatt tgaaaaatta ctatctaaag agaataattc agagaaaatg tttataaaat
     1501 attctgatat aggaaaatct ttaatagaga agatatttga tggatttttt attatgcaag
     1561 atatgaaaaa actaagagct aatgtcactg aagacattca atggtttgat ttttacaaca
     1621 aaactgaaat tacatctttt cctaaagtaa tagagcattt tgaaaaacat attaaaggta
     1681 aaaaattttc tattctttac aaaagtataa ccccacataa tactgaatca gattcattat
     1741 taattagtgg agaagccgtt ttatcagatg aagcttctga acatcaaaaa tatagcaatt
     1801 tctactttag tgcaaattgt ataatttcag aaaataaatt actcttagca aaattacatt
     1861 tggatttaat taaaactgct ggctatataa atgaatttga atcatattca atacctaaaa
     1921 tgacaaatac acatcttgat gaaagtaata ttttatcaca attttattca atgttgcctg
     1981 taggtataat tcgctacgat ttatttggtg atatgattat tacttatatg aatgaagaaa
     2041 tgtttgatat tataggttat acaaaagaac agttttttgg tgagatgggc ggaaatttaa
     2101 gagcaattgt tcatccagat gatttagact ttgtttataa aaaaagtttg gacatgattg
     2161 acacaaataa aattgaacca tttttatata gattcataaa acgagatggt caaattgtca
     2221 cagttatgta tacacaatgt aacctttctg caattgatgg aaggtcgatt gcccagggta
     2281 tgtatgtaga tgtaaataaa ataaaaaatt taacaaaaat ctagtacaaa gtattttatt
     2341 ttggagaaat taatatgttt aaagaaattt ttttaagaac ttttccagga tttctaatta
     2401 taagagattc taactacaga attatattta taaatgataa tttaaaaaat ttaattaaaa
     2461 gttatatgca agataatcca cttggaatga ctaatataga aatagctaag aaactccctg
     2521 ataatattgc taaatttttt acggattctc acaatattca attagattgg gaaaaaaatt
     2581 atccttatga taaaatttca aattggattt tagagtttaa aaaagatact acaagctatt
     2641 ggaatgtttt agaatacaaa gtagatgttg atgaaaaaac ctacataatt actatggcca
     2701 atgatataac aaaactctat gaagaaaata agagaaatct tcactactca attactgacc
     2761 cattaactgg agcatataat agaaaatatt taaatgatag atttgacata tttataggag
     2821 attatattgt actaattgac ttagataatt tcaaaatgat aaatgactat gaaggtcata
     2881 atgtaggaga caagatttta tgtgattttg tttcactttt aaataaagaa ttaataaatt
     2941 ctacttctat tatacgatta ggaggagatg aatttattgt tatattctct agtgatgttg
     3001 acaaaaatta tgtttattca cagctagaag ccttaagaga aaatttttta aaagtattct
     3061 ctaagtataa gtatctttca tttagttatg gtgttgatac agtaaaaaga aatttaaaat
     3121 tgacaatagt tgaattggat aaaaaaatgt ataaaaacaa ggagaaaaac aagaaaaaat
     3181 ttgataaaaa tgattattaa cattgttatt ttaaaataaa ttaaaattat ctttcttttt
     3241 ttaaacttgt acattagttt ataaatatgt atctatacaa gatattgaca ttaagtactg
     3301 aagcatatat tgtttcagtt cttttttgtt aaaattaact tatttaacaa agatatcata
     3361 gtttaacaaa gcttttaatt taaatatatt gatgtataat ataattaaaa tataatagca
     3421 aaaagaaagg aggaatatca tgagcatact cctaaaaaaa gcacccaaat tagcaaaaca
     3481 tattataaca agtttttata taaatcgaga tatcaatgaa gtattaaaat acctttgtga
     3541 aaatgttaca tggattggac caggagaaca ggaatttctc acttctttta atgaaataaa
     3601 aaattatttt tatgcaggtc aagatgaaat tccttcttgt gatataaata atgatatatt
     3661 tgaaactgta agtgaagatg agaatagatg tatggtatta ggaagatata ctgttcgaac
     3721 taaagaaaat gctcaaatga ttttagaggt aaatcaacgt tgtacatttg agataattga
     3781 ggatagagga aaattattaa taaagcacat gcacatatca aacccttatg gtgaaatgca
     3841 acttgatgaa tactttccca ctaaaattgg aactcaaagt tatgattatt tgcaaagatt
     3901 actaaaagaa aaaacagaag ttattgaaat gattacaaat aatatcaatg gtggcttaaa
     3961 aggtagcaat gatgatagta catactcatt tttctatgtc aatgagggat tgcccaaaat
     4021 attaggatac acatatgatg agttcatgga aatgagtggt ggttcagcag tgggtgctgt
     4081 atatccacca gacttaccta aagcactaga agattgtgaa cgatgttttg caaaaggacc
     4141 tacatattca tctgaatata gaatccgaaa aaaagatgga acattaatgt gggtattaga
     4201 ttctggaatg aaatcgttaa atagtgatgg catagtaaaa attaatagta ttattactga
     4261 cataacccaa ctaaaaaaca tagaatctga actaaaatta gaaagagagc gatatcgtat
     4321 tgctttgcaa aatattacag atatcatgtt tgagtatgat attgaaaacg atacccttat
     4381 aaaatatcaa cgtgtagaaa ttgacaaaaa aattgaatta gaaaattttg aaacaaaaaa
     4441 ttactccaaa ctattagaat ctggtaaaat tattcacctt gatgatattg gaaaactact
     4501 agaagtactt catggaaatc ttcgtgaaac aattgagata agacaagtaa attcattaac
     4561 taaaaatgaa tggagatgga ttcgtgttca atgttcagtt atatatgata gtgaccataa
     4621 tcctatcaaa acaataggcg ttttaaaaga cataactgaa gataaatcta aattagaaag
     4681 tttaattaat caggctcaac gtgacccact aacacaatta tataatcaaa gagtatcaca
     4741 aaatcttatt gaagagtatc tatgtagttc tgattccaaa aataatgatg ctctattagt
     4801 tattgatatt gatgatttta aaactgtaaa tgatactttt gggcatctag agggaaatga
     4861 agttttagtt gctgtatcaa aaatactatt acataacaca catgataaag acatagttgc
     4921 tcgaattggt ggagatgaat ttacaatatt tataaaatca ttaacaaagg atttaataat
     4981 aaaaattact aatgatattt taaatgatgc gagtaaaata aaagtaaagg acaatcataa
     5041 aataacatta agtattggta ttgccttcac tgatgattca actaaattat ataaagattt
     5101 attttctaaa gctgataaag ctctttatct atcaaaagca gatggcaaaa attgttatag
     5161 tacatacgaa taataaagct atttatacga ccaagaatga acctttaaat ttaatttcat
     5221 agtctaacaa tcaaagagtt gaagctaatc ttatagctag tcaactagtt cctagaaaaa
     5281 atttaaacaa tatatttatt gatactgctc atttttctaa agagcaaatt tatataaaaa
     5341 attaaacttt tatatacata cagatactaa tgataaacag ttatcattag tatcttctat
     5401 cttaaaacaa aatgataatt tatctatata aaaaagtgct ttgttgacag agttcacttt
     5461 tttatatagg tacagaattt aagtataaat acatgtttta ttctatacat tttagttaat
     5521 gtaaaatttc ttgattgtac tctctaactt ttcaacatta tactatttat ataccactta
     5581 gttaatataa aactataaaa gtgttgcaat tactgggttt tataaagtta atttacatac
     5641 cacttagtta atataaaact ttagcacctt atttatctat agagctacag aaagtattta
     5701 cataccactt agttaatata aaacatgtat ttatttgttc ttgtactatt gttttactct
     5761 atttacatac cacttagtta atataaaaca atatcaaaac aaataaaaat ttttaataaa
     5821 tcattattta cataccactt agctaatata aaacattctg gtactgttgc tatttatgtt
     5881 ccgtattcag aatttacata ccacttagtt aatataaaac tttggagttg ttacagatta
     5941 tttgccttat ctctctattt acataccact tagttaatat aaaaccccca aataaactgg
     6001 gcattttcaa tacttacaca tatgcaactc tcttaaattt gcagtgaacc atgagtagtg
     6061 caaatgataa agcttatcat ataccctcaa caccttatat ttcaagcgtt aagctctact
     6121 ttgtaacaaa tatcgctcac tgcaaaacta tttacatttt tattatatca taaatatatt
     6181 atttttgaat atctatacca atttgtggta taataaaagc aagaagaact acaatctatt
     6241 tagacgtaga gtgaagttca aatactaatg tttattcttt ttgaacttga tttttagttc
     6301 aaaactaaag tcactcctgc ctgtgtgaac tatacccgct gttttataca gttaaaacat
     6361 gtaaaaatag ttataaagta ctagtgtaac tcattagtac tctttttatt atattcatat
     6421 aattaatatc tatattttaa agcttactat ctaaaaaaga gcacgtcaaa taaaacccta
     6481 gatatttaat ttttttagag atacttaaaa taaattatgc tctctctgta cttaaatatt
     6541 tcctaaattc aaatggagac atagaattta atctattttg atatctaaaa ttattatagt
     6601 agtatatata atcatctatt gctttaacta attattcata tgtatcaaat ttccttaaat
     6661 agtacatttc tacctttaaa attccccaaa atccttccat aggagcattg tcaaggcaac
     6721 gaccaactct tgtataatat atgtatatct aacaccatta agaaatatat attttataat
     6781 atatatttct tcatttaatg cacttagaaa agcaaagaaa atacagatta gtacactttt
     6841 tagagaaaaa taaaattaat acatctaaaa tattaaaaaa tactttagat aatctaaaga
     6901 cacatctcaa agtttttaac taaattataa aactaattac aaatgctatg taacgataat
     6961 aaataaaaaa tttacttcgc ttaagcgacg tgtcgttgaa atatttcatg ttgccaactg
     7021 attcataagt cgataagaaa agaacactaa ttatttagag ttcttttctt agctacaagt
     7081 ggattataat acttttaaat ctgtgagaaa atcatatata ataatgatat gaacaagtaa
     7141 agaaaataca aaaatgacaa aattataaat aaaatattat aaaatcataa ggtcataatt
     7201 gttatattgt agaaacaaag taaagagaga gggtggagaa taaatgaatc aaaaaaaaat
     7261 aaagattagt attaaaatgg taattatagg tatattttct gtaattattg cttttgtatt
     7321 atccagatta ttcgttgagt atattgatga attattaagg tctaattggc aatatcagct
     7381 atttgaaagt gagagttcat atataatatt tgccaattgt attatgttct cgaatatatt
     7441 attagaaata tttttaatat atatttgtag aaaatttaga aaaatctaat atggtcaacg
     7501 tatttcgaat cgaatacttc atgattattt agtctattgt gctagttaaa gtttaattcc
     7561 catataaagt aaattgattt tagtaaaaca aatcacccct aagggttagt ttatggataa
     7621 gtcatccaaa tattaactct ttaatttttg ctatagattc atctttgctc ataactttac
     7681 ttataaaaaa tgaaatatta taagctagaa cttttattct aattctagtc ataaatccta
     7741 gcatagagtt acttttttta tattataaat aaaactatac aacaaagata atatttagta
     7801 aaaataactt tcattttaac taaacttaaa attcaattac tctctaaatt gacgtttagg
     7861 aattagttca aaataaaaaa gagtgtatat attgaaatta ctacatttca atatatatac
     7921 tctttttaaa tttctcagtt ttccatggaa ctttacttta tttatttctg tattagttgt
     7981 attttttatg catttttctt taaaatcata ttttctgatt caactcttat attataaaat
     8041 ttctttacta aattattctc tttttctata tcttcatata tattttt
//
LOCUS       DAEHWM010000133         7986 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.136, whole genome shotgun sequence.
ACCESSION   DAEHWM010000133 DAEHWM010000000
VERSION     DAEHWM010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7986)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7986)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7986
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.136"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(101..952)
                     /locus_tag="KNP36_003408"
     CDS             complement(101..952)
                     /locus_tag="KNP36_003408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase subunit GatY"
                     /protein_id="HBF0875253.1"
                     /translation="MALVTTTSMLKKAQDEGYAVGAFNVENMEMVIAVIEAAEELNSP
                     VILQTTPSTVKYAGLDYYLANAKVAAERVNIPVAMHLDHGSSFDLAMKALRSGYTSIM
                     IDGSHESFENNISISKSVVKACSPSLIPVEAELGKVGGKEDDLDGGNSNDYTNPKEAK
                     EFVDRTGISSLAIAIGTAHGLYKGEPKIDLDRLSEIKNVVSIPLVLHGGSGIHDDIIK
                     EAIKRGIAKVNYATELRIAYSKGVKKVLDEDSEVIDPKKYGLAGLQSVKDFVKEKIKV
                     CGSVNRV"
     gene            complement(1001..2170)
                     /locus_tag="KNP36_003409"
     CDS             complement(1001..2170)
                     /locus_tag="KNP36_003409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBF0875254.1"
                     /translation="MKMFKLEEQKLKDLGAIITTNEIKQQPELWLETYEIYKSNKEKL
                     SRFIDTISNNHGQFRVIFTGAGTSAYIGNSILPYLKNKNDIRKYIFEAIPTTDIVSNP
                     YDYLKKDIPTLLISFARSGNSPESLAALNLGNKIVDNFYHLAITCNPEGELAKMTKND
                     ENNYLLLMPSKSNDEGFAMTGSFSCMMLSAMLIFDSLEDDVEKSYINAIIEMGRNVID
                     RKDEIHELINKDFDRVVYLGSGGLGGLTQEAQLKLLELTAGKISTVYDSPMGFRHGPK
                     SFIDENTLVFEFVSNCLYTRKYDLDVLEEIKRDKIAKFTCAVSVENENNFSGTKFEFK
                     EKYNKLPDVYLAMPYILFAQTIALFVSVKVGNKPDTPSATGTVNRVVKGVTIYEY"
     gene            2641..3558
                     /locus_tag="KNP36_003410"
     CDS             2641..3558
                     /locus_tag="KNP36_003410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HBF0875255.1"
                     /translation="MKNIKMGMIGLGSIAQKAYLPILTKSERFEFVGAFTPNKVKREK
                     VCSDYRIMPFDSIESLAKKCDCIFLHSSTETHYEIIKILLNLGVHVYVDKPLASTVSQ
                     GEELIELSTKKNLNLMVGFNRRFCPMYKEIKNNATEIVSINICKHGLNSLRNVRFDST
                     LIDDYIHVIDTALWLANEDVEISGEDLFLTDNKNLIFVSHKLKGKNFSINTSMHRDSG
                     TKLEQVEILSKGKIQRVKNLNVLEIEEGGNLTLKQSGAWVNILKQKGFEDISNHFIDC
                     IENNIKPAINGEECIKAQRLLEKIINSVK"
     gene            complement(3687..4616)
                     /gene="pfkB"
                     /locus_tag="KNP36_003411"
     CDS             complement(3687..4616)
                     /gene="pfkB"
                     /locus_tag="KNP36_003411"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HBF0875256.1"
                     /translation="MITVITFNPSIDRMYRVNNINIGEVQRVVSKNATAGGKGLNVAK
                     VCKILKENPLAMGFLGGFNGEFIKNELRKLDIQNKFTKIEQETRNCLNIIEDNKVSTE
                     FLEKGPIVEKSDLERFENDIEEVLKNTKILVASGSYCENMPIDYYEKIGNICRANNIK
                     FILDTSGEALKIALKSKPYLIKPNIDEIRHLLGMNIESREEIILSGKKLIEMGAENVC
                     ISLGKDGMVYLNEDNVYDVKVPVVKCINTVGSGDSTVAGFSVGILRGYKIENLLKFAN
                     ACGISNALNMETGFVDLGEIDKYQDLVEVKKLS"
     gene            4885..5610
                     /locus_tag="KNP36_003412"
     CDS             4885..5610
                     /locus_tag="KNP36_003412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0875257.1"
                     /translation="MIKRNDKRPIYDQLVEILRTKIENEMEPNDRMLSERKICDEYGV
                     SRTTVRLAMAELEHMGYIYKRHGKGTFVAALSQNSQNLMESYSFTDYMRTQGKKPGTK
                     VLSFEVVESTKYFSEKLGITPGEKMIKIMRLRLADDLPMMLERTYLPMKEFIGLTKEK
                     IEQKPLYEIFREDYGEIIKVADEEFSAGIISDKEAKLLEVPGDSPCLKLLRTTYNDDN
                     IVIEFTLSVARSDKFVYRVRHVR"
     gene            5693..6847
                     /gene="nagA"
                     /locus_tag="KNP36_003413"
     CDS             5693..6847
                     /gene="nagA"
                     /locus_tag="KNP36_003413"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HBF0875258.1"
                     /translation="MKSFIYADKFFMKHGIKEKGYLSIINGKFGEFQQERPNVTDNVI
                     DFSGKYIAPGLVDTHIHGLLGADVMDNTFEAINTISKGLLKYGVTSFLPTTLTDSVDT
                     LSDSVENISNSFNRVEGAKIQGIYLEGPFFTEKYKGAQNEKYFKDPDINILKLWQKKS
                     KNLIRKIAIAPERKGSIELTRYATKNNISVSLGHSSATFEQVKQVVNSGAKVFVHTYN
                     GMSPLNHREPGMVGAAMVLKDTYAELICDGHHVSPIAVKIMMDAKSSNNIALITDCMR
                     AGAMEDGKYTLGKFNVNVKNSVARLNSGSLAGSVLTMDKAVRNIVDWNISTLEDAIKM
                     ATYVPALSCNIDNVCGSIYQGMDADFIVTDNDFNIHETYINGICKYKVNK"
     gene            complement(7556..>7986)
                     /locus_tag="KNP36_003414"
     CDS             complement(7556..>7986)
                     /locus_tag="KNP36_003414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="YbaK/EbsC family protein"
                     /protein_id="HBF0875259.1"
                     /translation="TFEEYDHEPILSFEKAKEIREKLQYTGVESKSLFIKDRSGNYYI
                     FVTTEGKKLDPKTIKNVLGGKVSICSKEELTQKTQCLPGCVSPFGYEKNISLVIDQDI
                     FNHDKIIFSPGIPEKTFIITASGFKKVINNINNTTYKYIY"
BASE COUNT         2806 a         1158 c         1019 g         3003 t
ORIGIN      
        1 attaaatgaa aaaaatacac catttacata taattaatat aaatttttca tataataaat
       61 atcctaaact tatctaaaat aaatttagga tattttattt ttatactcta tttacagacc
      121 cacacacttt aatcttttct ttcacaaaat cctttactga ttgaagccct gctaatccat
      181 actttttagg gtctataacc tcagaatctt catctaaaac ttttttaacc cctttactat
      241 atgcaattct taattcagtt gcatagttaa cttttgcaat acctcttttt atagcttctt
      301 ttataatatc atcatgtatt cctgaacctc catgcaatac taaaggtatt gaaactacat
      361 ttttaatttc tgataaccta tctaaatcta ttttaggttc acccttatac aatccatgtg
      421 cagtacctat agcaatagcc aatgaagata ttcctgttct atcgacaaac tcttttgcct
      481 cttttggatt tgtataatca ttactattcc cgccatctaa atcatcttct tttccaccaa
      541 ctttcccaag ttctgcttcc actggtataa gagaaggact acatgctttt actactgatt
      601 tagatataga tatattattt tcaaagcttt catgagaacc atctatcatt attgatgtat
      661 atccacttct taaagctttc attgcaaggt caaaacttga accatggtcc agatgcattg
      721 ctacaggtat atttactctt tctgcagcaa cctttgcatt tgctagataa taatcaagac
      781 ctgcatattt tacagtagat ggagtagttt gtaatattac tggagaattt aactcctcag
      841 cagcttctat aacagcaatt accatttcca tattttctac attaaatgct cctactgcat
      901 acccttcatc ttgtgccttt ttaagcattg atgttgttgt tactaatgcc acattgatac
      961 cctcccaaat tatttagtta taatatttta atcttatctt ttaatattca tatattgtta
     1021 caccttttac tactcgattt actgttcctg tagctgatgg agtatctggc ttatttccaa
     1081 cctttactga tacaaacaat gctatagttt gtgcaaacaa tatgtatggc attgcaagat
     1141 acacatctgg taatttatta tacttttctt taaactcaaa ctttgttcct gagaagttat
     1201 tttcattttc tactgacact gcacaagtga atttagcaat tttatccctt tttatctcct
     1261 ctaaaacatc taaatcatat tttcttgtat ataaacagtt agatacaaat tcaaatacaa
     1321 gtgtattttc atcaataaat gattttggtc cgtgtctaaa ccccatagga gaatcataca
     1381 ctgtagatat ttttcctgct gtaagttcta aaagttttag ttgtgcttct tgtgtcaaac
     1441 cacctaatcc tcctgaacct aaatatacaa ctctatcaaa atctttattt attaactcat
     1501 gtatttcatc ttttctatct ataacatttc ttcccatttc aattattgca tttatatatg
     1561 acttttctac atcatcttct aaactatcga atattaacat agcagataac atcatacacg
     1621 aaaaacttcc tgtcatggca aagccttcat catttgattt tgatggcatt aataacaagt
     1681 aattattttc gtcgttttta gtcatcttag ccagttctcc ttctggatta caagttatag
     1741 ctaaatgata aaaattatct acaatcttat tccctaaatt taaagctgct aaactttcag
     1801 gactatttcc acttcttgca aatgaaatta ataatgttgg tatatctttt tttaagtaat
     1861 catatgggtt tgaaactata tccgtagtag gtattgcttc aaatatgtat tttcttatgt
     1921 catttttatt tttaaggtaa ggaagtattg aatttcctat gtaagctgaa gttccagcac
     1981 ctgtaaatat aactctaaac tgcccatgat tattacttat tgtatctatg aatctactta
     2041 atttttcttt gttagattta tatatttcat aagtttctaa ccataattca ggctgttgtt
     2101 ttatttcatt agttgttatt attgcaccta aatcttttag tttttgttct tctaatttaa
     2161 acattttcat tctcctttca tacttgtaac gtttacattt ggtaatgagg ttataaccac
     2221 tttaaactat aaaaaaatat actcttttat aattttttgc ttagattttt tagtactact
     2281 taaactcact ataaaatata cactatagat tttaattaat tttatagttt atctttaaaa
     2341 atttaataaa atcatactct atatacttta gtatttttat tttacgataa aagcttgttc
     2401 agaccaaagt ggtaattacc actaatccaa atataaatta atttgaattt tttgtcaata
     2461 cataaaatat ttatatcaat caattttatg gatatcctac aaaattactt tatcaatatt
     2521 tcttatttcg ctaatttact tatataagct ttaaatttat tttttgatac aaagtttaca
     2581 aatttatgtg tctgaattat aatcaattct gtaaatataa aaaccttagg agaaagtatt
     2641 atgaaaaata taaaaatggg aatgataggt cttggctcca tagctcaaaa ggcatattta
     2701 cctatattaa ctaagtctga gagatttgag tttgtaggag cttttactcc aaataaagtt
     2761 aaaagggaaa aagtctgtag tgattataga atcatgccat tcgattctat tgaatcccta
     2821 gctaaaaaat gtgattgtat ttttctacat agctctacag aaacacacta cgaaattata
     2881 aaaatattat taaatttagg tgttcatgta tatgtagaca aacctcttgc ttcaacagta
     2941 agtcaaggag aagaacttat cgagttaagt acgaaaaaaa acttaaattt aatggttgga
     3001 ttcaaccgta gattctgtcc tatgtacaaa gaaattaaaa ataatgctac agaaattgta
     3061 tctatcaata tatgtaaaca tggattaaat tccttaagaa atgttagatt cgacagtact
     3121 cttatagatg actatataca tgttattgac actgctttat ggttagcaaa tgaagatgtt
     3181 gaaattagtg gagaggattt atttttaaca gacaataaga atcttatatt tgtaagtcat
     3241 aaacttaaag gtaaaaattt ctctataaac acctctatgc atagagattc tggaacaaag
     3301 ttagaacaag ttgaaattct ttcaaagggt aagattcaaa gagttaagaa tcttaatgta
     3361 ctggaaatag aagaaggtgg aaacctaact ttaaagcaaa gtggtgcatg ggtaaatata
     3421 ttaaaacaaa agggttttga ggatatatca aatcatttta ttgattgtat agaaaataat
     3481 ataaaaccag ctattaatgg agaagagtgt atcaaagctc aaagattact agagaaaatt
     3541 ataaattcag taaaatagat atttattata aaaataggtt aaaaatgaat ttttctaacc
     3601 tatttttata taagactata tcttttatat taaaattaaa atctattaca acaacattaa
     3661 atttattata ttcccattaa atgtatttaa cttaactttt ttacttcaac taaatcttga
     3721 tatttatcaa tttctcccaa atctacaaat ccagtttcca tatttaaagc attacttata
     3781 ccacaagcat ttgcaaattt aagtaaattt tctattttat aaccccttaa aatacctaca
     3841 ctaaatccag ccactgtgct atctccacta cctacagtat ttatacactt tacaactggt
     3901 acttttacat catatacatt atcttcgttt aaatacacca taccatcttt tcctaaagat
     3961 atacatacat tctctgcacc catttcaata agtttttttc ctgacaagat aatttcctct
     4021 cttgattcta tattcattcc taataaatgt cttatttcat ctatatttgg ttttattaaa
     4081 tatggttttg attttaaagc tatttttaat gcttctcctg atgtatctaa tataaacttt
     4141 atattatttg ctctacatat atttcctatc ttttcataat agtctatcgg catattctca
     4201 caataactac cagaagctac cagtatttta gtatttttta gtacttcctc tatatcattt
     4261 tcaaatctct ctaaatcgct tttttctact attggtcctt tttctaaaaa ttctgtacta
     4321 actttattgt cctcaattat gtttaagcaa tttctagttt cctgctctat ttttgtaaat
     4381 ttattttgta tatctagttt tctaagttca ttttttataa attctccatt aaatccgcct
     4441 agaaatccca tagctaaagg attttctttt aaaattttac ataccttagc tacgtttaat
     4501 cctttacctc cagcagttgc attcttactt actacccttt gcacctcacc tatgtttata
     4561 ttattcactc tatacattct atctatagat gggttgaatg ttattactgt aatcatacta
     4621 gattctcctc attattaatt tttacttttc taaacaataa attaatctgt aaaataaaaa
     4681 atacctcatc tataatatac ccaaagtggt tattaccaat ttgaatataa attattttac
     4741 ttgttttgtc aatgtaccat aattttataa taaattaata accttactta ttgaattttg
     4801 attaaacttt attcattgac ataaataatt ctatattcta taatcaaatt gtggtaataa
     4861 ccacttagaa aggactatat ttttatgata aaaagaaatg ataaaagacc aatatatgac
     4921 cagcttgttg agatattaag aactaagatt gaaaatgaga tggaaccaaa cgatagaatg
     4981 ctttccgaaa gaaaaatttg tgatgaatat ggagtaagta gaaccacagt tagactagct
     5041 atggctgagt tggaacatat ggggtatata tacaaaagac atggaaaagg aacttttgtt
     5101 gctgcactaa gtcaaaattc tcaaaactta atggaaagtt atagttttac agattatatg
     5161 agaacacaag gaaaaaagcc aggtacaaag gtattatcat ttgaggtagt agaaagtaca
     5221 aagtatttct ctgaaaaatt aggtataact cctggtgaaa aaatgataaa aataatgcgt
     5281 ttaagacttg ctgatgacct tcctatgatg cttgaaagaa catatcttcc tatgaaagaa
     5341 tttataggat tgacaaaaga aaaaatcgaa caaaaacctt tatatgaaat atttagagaa
     5401 gattatggcg agattattaa agttgctgat gaagaatttt cagctggaat aatctctgat
     5461 aaggaagcta agttattgga agtaccagga gattcacctt gtctgaaatt acttcgtacc
     5521 acatataatg atgacaatat agttattgaa tttactttga gtgttgctag aagcgataaa
     5581 tttgtatata gagtaagaca tgtaagatag taagttaaat aactttcaag aaaatagaat
     5641 gatattataa acgtcaatgc cacaatgata gtataattat aaggaggtta ttttgaaaag
     5701 ttttatttat gcagataaat tttttatgaa acatggaatc aaagaaaaag gttaccttag
     5761 tataattaat ggcaaattcg gtgaatttca acaagaaaga cctaatgtta ctgataatgt
     5821 tatagatttt tcaggtaaat atattgctcc tggcttagtt gatactcaca ttcacggtct
     5881 tttaggtgca gatgtcatgg acaatacatt tgaagcaata aacacaattt caaaaggctt
     5941 attaaaatat ggagtaacat ctttcctacc tacaacttta actgattctg tagatacact
     6001 aagtgattct gtagaaaata taagcaatag cttcaatcga gttgagggtg caaaaataca
     6061 aggtatttat ttagaaggtc cattttttac agaaaaatat aagggcgctc aaaatgaaaa
     6121 atattttaaa gaccctgaca tcaatatatt aaaattatgg caaaaaaaat cgaaaaattt
     6181 aataagaaaa atagcaattg ctccagaacg taaaggttca atagaattaa caagatatgc
     6241 aactaaaaat aatatatcag tttctcttgg tcatagttca gctacatttg agcaagttaa
     6301 acaagtcgtt aattcaggtg ctaaagtgtt tgtacataca tataatggga tgagtccttt
     6361 aaatcataga gaacctggaa tggttggggc tgctatggta ctaaaagata cttatgctga
     6421 attaatttgt gatggtcatc atgtaagccc aatagctgtt aaaataatga tggatgcgaa
     6481 gtctagtaat aacatagctt taattacaga ttgtatgaga gctggtgcta tggaggatgg
     6541 aaaatatact cttggtaagt ttaatgtaaa tgtaaaaaat agtgttgcaa gattaaatag
     6601 tgggagttta gctggaagtg tattaactat ggacaaggct gtgagaaata tagttgattg
     6661 gaacatatca actttagaag atgcaataaa aatggctaca tatgtccctg ctttaagttg
     6721 taatattgat aatgtctgtg gctctatata tcaaggtatg gatgcagact ttatagtaac
     6781 agataatgac tttaatatac acgaaactta tataaatggt atctgtaagt acaaagttaa
     6841 taaataggtt caatataagg ttatggaggc tgtctaaaaa gagtctggaa atatttaaag
     6901 ttatttctcc aaaatctgat ttaacacttt tatttccata tcgttaataa actattgcga
     6961 tagaggttat tttaaacaaa tatatattat aagtattttt gtgataatat tttcgataat
     7021 atgtacattt aaagtaactt ttctattatt atttgtaagt ttttatcttg agcaaacata
     7081 taaattttta ataaagcatg agataaaccc tatatttcaa ttactaatga tgagattttg
     7141 attgataaca gatatatttt caaatgtaaa aatactaaaa atcatatcaa ttttaaagat
     7201 attgtaggtg taaataaaca agataatact atagaaattt ttacaaatga aagcacttat
     7261 tgtatatatc taaaagtttt aagcattgag agcgaagaat atctaataga tagactaaaa
     7321 tcattttgtt gattttatat attttatgtt aaatataaag cagagtagtt aaaactaccc
     7381 tgcttttgta attaaaattt aaaaataata actcataata cattgaattt gagcttaaca
     7441 gtaactattg taataatagt atcaatcttt tgtgttgaat ataatttatt tacactatag
     7501 ttaagcatga tttctaatgt tattttctct aatttacaat tatgattaaa attcattaat
     7561 atatatattt ataagttgta ttgtttatat tgtttattac ttttttaaat ccactagctg
     7621 taataataaa tgtcttttct ggtatccctg gtgaaaagat tattttatca tggttaaata
     7681 tatcttgatc tattacaaga gagatatttt tctcatatcc aaaaggagat acacatccag
     7741 gcaaacattg tgttttttgt gttaattctt cttttgaaca tatagatact tttccaccta
     7801 aaacattttt tatagttttt ggatctaatt tttttccttc tgtggttaca aatatatagt
     7861 aatttccaga tctatctttt ataaataaac ttttactttc tactccagta tattgtaatt
     7921 tttctcttat ttctttagct ttttcaaatg ataaaatagg ttcatggtca tattcttcaa
     7981 acgtta
//
LOCUS       DAEHWM010000134         7945 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.137, whole genome shotgun sequence.
ACCESSION   DAEHWM010000134 DAEHWM010000000
VERSION     DAEHWM010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7945)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7945)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7945
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.137"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            49..366
                     /gene="trxA"
                     /locus_tag="KNP36_003415"
     CDS             49..366
                     /gene="trxA"
                     /locus_tag="KNP36_003415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HBF0875260.1"
                     /translation="MVKIVNNNEFINEVENKDGLVVVDFFATWCGPCKMLSPIYEALG
                     NEMVEKANFLKVDIDQSIELAQKFEVSTVPTMLIFKDGKPVDRLIGFMPKENLKNKIE
                     SYM"
     gene            complement(573..1847)
                     /locus_tag="KNP36_003416"
     CDS             complement(573..1847)
                     /locus_tag="KNP36_003416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBF0875261.1"
                     /translation="MQFMDVSKYIEGANLKVKTKSGETVKRIYFNNSATPLVLKNVVD
                     NLNCEIPLLTYINAPGIISEKNTLKYENVRSTILKLIDGDEEKDSVIYVKNATEGINF
                     LAKFFKDENPDKFVITTAMEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYA
                     GNVSLVTVTGASNVTGITTPIYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEH
                     IDFVVFSAHKCYSPLNGGALVGPKKFFEKFNPVLYGSGSTKFVNDNKILYANVPQRFE
                     AGYPEYFGTLAMGKALNTLNKIGLNRISKYERELFLYAKEEMSKIPNIIIYGDKSNNV
                     IIPNISFNISNMYYKDVAKYLVDNFGIETGAGVVGADIYVQKLLGISPKEAYVRFMRE
                     NPVGLVRISLGMYNTFDEVDSFIHAIKTLAFK"
     gene            2728..3564
                     /locus_tag="KNP36_003417"
     CDS             2728..3564
                     /locus_tag="KNP36_003417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HBF0875262.1"
                     /translation="MNIKKIFNNNVVVSSLEDGTEIIVTGAGVGFKKKVGDLIDENLI
                     SKKYFVQDDQRDKYNQILNKTSIEYFKISEEIIEKANEVLNTQVNDSIILALTSHIEF
                     AVQREKQGIKLPNLILNETKQLYREEFEFGLWAIDEIEKRIGIKLPEDEAGYIAIHII
                     NGLENSQKDEGINILEFSKQVIQIIEEVHGFKLDVNSLNYTRLITHLKFFVQRILRKE
                     TYNDSDIEDMYKLVNKNYNKPKVCTEEIAALVLDRFEYKISKEEELYLMIHINKITNS
                     GC"
     gene            3917..5494
                     /locus_tag="KNP36_003418"
     CDS             3917..5494
                     /locus_tag="KNP36_003418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HBF0875263.1"
                     /translation="MKKNKLGLWNFFQMLGKTFMFPIALLSVSGMMLGLGAGFTDPKM
                     IEMVPFLGNEYVNLVLNFMLTIGLFAFNNLGALFAMAIPLGLLKKEKEFGAFSGLVGF
                     IAMHIGTNFYLTRADLLVPAEQMSTNGQAMIMGIQTYNTSVLGGIVAGLIVYAIYDKV
                     SNLKIPESLGFYSGPRLVPIVSLIVMSIVGLLIPIVWPPFFNAFQSLGRWISSAGPLG
                     YFSYAVAERVTIPFGLNHLVTSVFRFTPIGGTAVIDGETYFGTLNMFMAYVENNQIIP
                     LDLAGKMEQGKLMIQYGLAGAALAIYRTAKPENRKALKGLLISGVLTVIIGGISEPIE
                     FLFLFISPALFAFHTFMNGLANMVLPYLGVLMGFTGDLIAFISFGVLRGTATGWPIAV
                     LVAVLYFAIYYFVFKWAIIKFNIKTPGREDKEIKVSEGNGSNFKNLSTYKGQQMISAL
                     GGQSNILSLDNCVTRLRLKLQDVSLINEDAIKEAGGIAVVKLDEHTIQVIIGTQVYSL
                     RKQMDKAMEGHLEACND"
     gene            5487..6671
                     /locus_tag="KNP36_003419"
     CDS             5487..6671
                     /locus_tag="KNP36_003419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PatB family C-S lyase"
                     /protein_id="HBF0875264.1"
                     /translation="MINFDKKVDRLGTYCTQWDYVEDRFGKKDLLPFTISDMDLEFPF
                     EITEVLQERLNHRVLGYSRWKHDDFRNSVTNWYIKRFNCSVDSNWIYYSPSVMYSISK
                     LIEMLSNEGDGILINTPAYNAFYDVIINNNRNIIKSHLVNRNGFYSIDFNDFEKKCKK
                     SKIFILCNPHNPTGRVWSELELVKMIGICKNNDVKIISDDIHMDIVYDNRMTPILNVA
                     KDYLDSVFICTSASKSFNIPALTGSYVIIPNEGIRNKFENITRYRDFVNSPAILAILA
                     TMVCYDDCEYWLDELLKYLKENLKYTIDYIKDNLEPLKLVMPEGCYFAWIDFSELKIS
                     GEKFQKLLMDIGEVAIMSGSVYGEEGEFYLRLNVACSREKLEDGLNRIKKTMDYIEKR
                     IL"
     gene            6689..7288
                     /locus_tag="KNP36_003420"
     CDS             6689..7288
                     /locus_tag="KNP36_003420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HBF0875265.1"
                     /translation="MGYLKTMVDVMTTEMNAIRCLIDEAGIEYESIVSEIANCEGKVI
                     FMGVGKSAHIGKKLAATFASTGTPSFFVHATEAVHGDLGMIESKDITILISNSGNSME
                     VVNCIKYIKAIGSKTIAFTSNRNSVLAKECDYALIYPAKDEADHLNLAPTTSSTITLV
                     LGDSIACALSKSSNFGSSDFYKYHPGGSLGEKLKTANNG"
     gene            7312..7782
                     /locus_tag="KNP36_003421"
     CDS             7312..7782
                     /locus_tag="KNP36_003421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0875266.1"
                     /translation="MFKMFKKKSIKSPISGKVIELSKIQDGVFSQKIMGEGVAIDSTG
                     DIVYAPINGKIVVVAETKHAFVIELENGMELLIHVGLDTVNLKGEGFEALVSMGEQVK
                     EGTPMLKINRPLIESKGISLITPVTITNHSEYNMNTCNVGNSVEGGKDTVIEFK"
BASE COUNT         2975 a          875 c         1379 g         2716 t
ORIGIN      
        1 aggtcgtagt atattaatat caagaagata ataaaggaga tgtatattat ggtaaaaata
       61 gtaaataata atgaatttat aaatgaagta gaaaataaag atggtttagt agttgtagat
      121 ttctttgcga cttggtgtgg accttgtaag atgctatcac caatatatga agctttagga
      181 aatgagatgg ttgaaaaagc aaacttcttg aaggtggaca tagaccaaag tatagaatta
      241 gctcagaaat ttgaagtatc tacagtacca actatgctaa tatttaagga tggaaaacct
      301 gtagatagat taataggttt tatgcctaag gagaatttaa aaaacaaaat tgaatcatat
      361 atgtaattaa agtaaattga agtaattaaa ataaatctca tatataaaca aaaaaactca
      421 ttgtaatgag ttttttgttt gtatagtgta aaatagtttg tatagttaca aatgagtgtc
      481 taattgctaa tgaaattgac tgttgatata atttgctttt ttgtgaaaac aaaactactc
      541 tctatttatt gataaaaaag aatagaaaaa acttatttaa aagccaaagt tttaatagca
      601 tgtataaagc tatccacctc atcaaaagta ttgtacattc ctaagcttat cctaacaaga
      661 cctacaggat tttccctcat aaatctgaca tatgcttctt ttggacttat acctaataat
      721 ttttgtacat aaatatctgc acctactact ccagctccag tttctattcc aaagttatca
      781 actaaatatt ttgctacatc tttgtaatac atattactta tattaaaaga tatatttggg
      841 ataattacat tatttgattt atctccatat attattatat taggtatttt actcatttct
      901 tctttagcat ataaaaataa ttctctttcg tattttgaaa ttctgtttag accaatttta
      961 tttaaagtgt tcagtgcttt tcccattgca agagttccaa aatactctgg gtatcctgct
     1021 tcaaaacgtt ggggtacgtt tgcatatagt attttgttat catttacaaa tttggtagaa
     1081 cctgagccat atagtacagg attaaatttt tcaaagaatt ttttaggtcc taccagagct
     1141 cctccattta gtggagaata acatttatga gcactaaaaa caacaaaatc tatatgctca
     1201 tcacattcat gtggcatcat tgaaaaaggt ttatgctgaa ttacttgcac aatatccacc
     1261 aatatctttg caccatactt atgagctatt cttgctattt catatatagg agtggttata
     1321 cctgtgacat tactagctcc tgtaactgta acgagagata cattaccagc ataattttta
     1381 agtatattct ctaattgaca taaatcaagt tctccttttt ctgtaattcc aacaactttt
     1441 gtaggaaaat taactttaaa aggcaggtaa ttagccatat gctccattgc tgtggtaata
     1501 acaaatttat ctggattttc atctttaaaa aattttgcta agaagtttat tccttctgta
     1561 gcatttttga cataaataac agaatccttt tcttcgtctc catcaataag tttgaggata
     1621 gtagagcgta cattttcata ttttaaagta tttttttctg agattattcc tggagcatta
     1681 atataagtaa gcaaaggaat ctcacagttt aagttatcca ctacgttttt taaaactaat
     1741 ggagtggcag agttgttaaa atatattctt ttaacagttt caccactttt agttttaact
     1801 ttaaggtttg caccttcaat gtatttagat acatccatga attgcataaa aaaacccctt
     1861 atctaataaa ctattctgtt ttttattaaa aaagctcaag ttttaatcaa gagcttgttt
     1921 aatatatgtt atgtttttat aaggggtttt gttaattaat tcttgttgag atgtttatta
     1981 aattacacga aaatgagcta cagttggggg aaactgtagc tcacttgatt ttgggggaga
     2041 taggttgaac ttattgttta tccgtatcat atttttagta tagtcactta ttttaattta
     2101 tatacatttt tttataaatt ttacataaaa tgttaaacac taattagaaa taattatgaa
     2161 tatgactaat aaagttgtaa aaatagtaaa gaaattgatt agaacataat ggaaaatata
     2221 ttgtatataa ttagaaaaaa agattttata tgttataaaa gatgtgcaag tataataatt
     2281 ttataaaaaa tacaaaatat aatacaaata attttataaa aaaaattata aaaaaattta
     2341 atttatataa attaaaaatt atattaccaa tgtatatatt tgagaaaaga ttagtacaaa
     2401 gctataatct gaatttcaat aaatatatat ataattaagt tgaaacactt gaaaatactg
     2461 gaaaaaattg aaaatagttt ttgtaatata aaatgtcgat tgattttaaa taattaaata
     2521 tacataagaa ataattaaat atatttcaat gaaaatatga taaaatatga caaattaatt
     2581 gatgacaata aaaaatattt tgttattgta gtattatagg gtaaattgca aaatatatac
     2641 gaaagtaaaa ttttaaatat tgacattaaa ttaaatatac tatactatgt aagtgtgatg
     2701 agagaatttt tttagagggg atttatagtg aatataaaaa agatatttaa taacaatgta
     2761 gtagtaagct ccctagaaga tggcacagaa ataattgtca ctggtgctgg agtaggattt
     2821 aagaaaaaag taggcgattt gatagatgaa aatttgattt ctaagaaata ttttgttcaa
     2881 gacgatcaaa gggacaaata caatcaaata cttaataaga cctctattga atactttaaa
     2941 atttcagaag aaattataga aaaggctaat gaagttttaa atactcaagt gaatgattca
     3001 ataatattag ccttaactag tcacatagaa tttgctgtcc aaagagaaaa acaaggtata
     3061 aaattaccaa acttaatatt gaatgagaca aaacaacttt atagggaaga atttgaattt
     3121 ggattatggg caattgatga aattgaaaaa aggataggaa taaaattgcc tgaagatgaa
     3181 gcaggatata ttgctattca cataatcaat ggtttggaaa attctcaaaa agatgaaggt
     3241 attaatatac tagagttttc aaaacaagtt attcagataa ttgaagaagt acatggattt
     3301 aaattggatg taaattcatt aaattatact agacttataa ctcacttaaa gttttttgtt
     3361 caaaggattc tccgaaaaga aacttacaat gatagtgata ttgaagatat gtataagtta
     3421 gtgaataaaa attacaataa acctaaagtg tgtactgaag aaattgcagc attggtatta
     3481 gacagatttg aatataagat tagtaaagaa gaagaattat atttaatgat tcacataaat
     3541 aaaataacaa acagtggttg ttaggattgt aactgataaa gcaggcaaaa cctaagtcat
     3601 tgagcttaac tattagatta agttttttga tttaggtttt tttattagat acaatcaaaa
     3661 tacagacagt gacttttagg attgtaactg gttaagcagg caaaacctaa atcattgaat
     3721 ttaactatta ggttaagttt tttgatttag gtttttttat tagatacaat caaatacaga
     3781 cagtggttgt taggattgta actggttgag caggcaaaac ctaaatcatt aaacttaatt
     3841 attaaattaa gttttttgat ttaggttttt ctataaattt gattatgttt ttagataaaa
     3901 ataggagggg aaaattatga aaaaaaataa gttaggttta tggaacttct tccaaatgtt
     3961 aggaaaaacg tttatgttcc caatagcact acttagtgtt tctgggatga tgctaggact
     4021 tggggcaggt tttacagacc ctaagatgat tgaaatggtt ccatttttag ggaatgaata
     4081 tgttaactta gttttaaact tcatgttaac aataggatta tttgcattta acaacttggg
     4141 agcattattt gcaatggcaa ttccactagg attattaaaa aaagaaaaag agtttggtgc
     4201 tttttcagga ttagtaggat ttatagcaat gcatataggt acaaattttt atttaacaag
     4261 agctgatttg ttagtaccag cagaacagat gtcaactaat ggtcaagcta tgattatggg
     4321 tatacaaaca tataatacaa gtgttttagg tggtattgta gcaggattaa ttgtttatgc
     4381 aatatatgat aaagttagta atttaaagat accagaatca ttaggattct acagtggacc
     4441 aagattagtt ccaattgtta gtttaatagt tatgagtata gttggattat taatacctat
     4501 tgtttggcca ccatttttca atgcattcca aagtttagga agatggattt cttcagcagg
     4561 accattagga tatttttcat atgcagtggc agaaagagtt acaattccat ttggactaaa
     4621 tcatcttgta acatctgtat tccgttttac accaataggt ggaactgctg ttattgatgg
     4681 agaaacgtac tttggtacat tgaacatgtt tatggcatat gtagaaaata atcagattat
     4741 acctcttgat ttagctggta aaatggaaca aggtaaattg atgattcaat atggattagc
     4801 tggtgctgca ttggctatct accgtacagc aaaaccagaa aatagaaagg cacttaaagg
     4861 acttttaata tcaggagtgt tgacagttat tataggtggt ataagtgaac caatagagtt
     4921 tctattctta ttcatatcac cagcattatt tgctttccat acatttatga atggtctagc
     4981 aaacatggta cttccatact taggcgtgtt gatgggattc acaggagatt taattgcatt
     5041 tataagtttt ggtgtgttaa gaggaacagc tacaggatgg ccaatagcag tattagtagc
     5101 agttttatat tttgcaatat actattttgt atttaagtgg gcaattatta agtttaatat
     5161 aaagacccca ggacgtgagg ataaagaaat aaaagtatct gaaggaaatg gttcaaattt
     5221 caaaaatttg tctacatata aaggacaaca aatgatatct gctttaggtg gtcaatctaa
     5281 tatattatca ctagataatt gtgtaactag attacgttta aaattacaag atgtatcatt
     5341 aataaatgag gatgcaatta aagaggctgg tggtatagca gttgttaaat tggatgagca
     5401 tacaatacaa gtaattatag gaacccaagt gtattcttta agaaagcaga tggataaagc
     5461 tatggaaggt catttggagg catgtaatga ttaattttga taaaaaagta gaccgattgg
     5521 gtacatattg tacccagtgg gactatgtag aagatagatt tggtaagaag gatttgcttc
     5581 cttttacaat ttcagatatg gatttagagt ttccatttga aataacagag gtgttgcagg
     5641 aaaggttaaa tcatagagtt ttgggataca gtagatggaa acatgatgat tttagaaatt
     5701 cagttacgaa ttggtatatt aaaagattta attgtagcgt tgatagtaac tggatatatt
     5761 atagtccaag tgtaatgtat tcaattagca aacttattga gatgttaagt aatgaaggag
     5821 atggaatcct tataaatact cctgcataca atgcttttta tgatgtgata ataaataaca
     5881 atcgtaatat tataaagtca catcttgtaa ataggaatgg attctattca attgatttta
     5941 atgattttga gaaaaagtgt aaaaaatcta agatatttat tttatgtaat cctcacaatc
     6001 caactggtag agtatggagt gagttagaac ttgttaagat gataggaatt tgtaagaata
     6061 atgatgtcaa gataatatca gatgatatac acatggatat tgtatatgac aatagaatga
     6121 cacctatctt aaatgttgca aaggactatt tagattctgt attcatttgt acatcagcgt
     6181 ctaaatcttt caatatacca gcattgactg ggtcatatgt gattatacca aatgaaggta
     6241 ttagaaataa atttgaaaat atcactagat accgtgattt tgtaaattcg ccagcaattc
     6301 tagcaatatt agccacaatg gtctgttatg atgactgcga atattggtta gatgaactat
     6361 taaaatacct taaagagaat cttaaatata cgattgatta tataaaagat aatttagaac
     6421 cattgaaatt ggtcatgcca gaaggctgtt actttgcttg gatagatttt tccgaactta
     6481 aaataagtgg tgagaaattc caaaaattat tgatggatat tggagaagtt gctattatgt
     6541 cggggtctgt atatggtgaa gaaggtgagt tttatttaag gttaaatgtg gcatgttcaa
     6601 gagaaaaact tgaagatggt ttaaatagga ttaaaaaaac tatggattat attgaaaaaa
     6661 gaattttata gtaggaaggg agatagttat gggatattta aaaacaatgg ttgatgttat
     6721 gactactgaa atgaatgcca taagatgttt aatagatgaa gcaggaatag aatatgaaag
     6781 tatagttagt gaaattgcaa attgtgaagg caaagtaatt tttatgggtg taggaaaatc
     6841 tgcacatata ggtaagaaat tggcagctac atttgctagt actggtacac ctagcttttt
     6901 tgtacatgca acagaggcag tgcatggaga tttaggaatg attgaaagta aggatattac
     6961 aattttaata tcaaatagtg gaaattctat ggaagtggta aactgtataa aatatattaa
     7021 agcaataggt tctaagacaa ttgcatttac ttcaaacaga aattcagtac tggcaaaaga
     7081 gtgtgattat gctttaatat atcctgcaaa ggatgaagca gaccatttaa atctagcacc
     7141 aacaacatca tctacaatta ctttggtttt aggagattct attgcatgtg cattatctaa
     7201 gagtagtaat tttggttctt cagattttta taagtaccat ccaggaggaa gtttaggtga
     7261 gaagttaaaa acagctaaca atggataaaa gcaaaaagga gagtagtttt tatgttcaaa
     7321 atgtttaaaa aaaaatcaat aaaatcaccc atatcaggaa aagtaataga gttatctaaa
     7381 atacaagatg gtgtattttc tcaaaaaatt atgggagagg gtgtagctat agattctaca
     7441 ggagacattg tatatgctcc aatcaatgga aagatagtag tagtagcaga gactaaacat
     7501 gcatttgtaa tagaattaga aaatggaatg gaacttctta ttcatgttgg tttagatact
     7561 gtaaatttaa aaggcgaagg ttttgaggca ttggtgagta tgggagaaca agtgaaggaa
     7621 ggaacaccaa tgttgaaaat taaccgtcct ttgattgaat caaagggtat atcacttatt
     7681 actccagtta caataactaa tcattcagag tacaatatga atacatgtaa tgtaggcaat
     7741 agtgttgaag gtgggaaaga tactgtaatt gagtttaaat aaagaactaa aatacaaggt
     7801 taatatttat aaatacctat aaacttatgt tttataagat tgattgtata gatttgttgt
     7861 ataaaaaaga actctttaat tataaattaa ggagttcttt tttattttgt aaatattgtt
     7921 tagatttata tagaaaaaca cttag
//
LOCUS       DAEHWM010000135         7904 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.138, whole genome shotgun sequence.
ACCESSION   DAEHWM010000135 DAEHWM010000000
VERSION     DAEHWM010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7904)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7904)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7904
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.138"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            27..101
                     /locus_tag="KNP36_003422"
     tRNA            27..101
                     /locus_tag="KNP36_003422"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:59..61,aa:Thr,seq:tgt)
     gene            116..200
                     /locus_tag="KNP36_003423"
     tRNA            116..200
                     /locus_tag="KNP36_003423"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:150..152,aa:Tyr,seq:gta)
     gene            210..293
                     /locus_tag="KNP36_003424"
     tRNA            210..293
                     /locus_tag="KNP36_003424"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:244..246,aa:Leu,seq:tag)
     gene            317..391
                     /locus_tag="KNP36_003425"
     tRNA            317..391
                     /locus_tag="KNP36_003425"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:349..351,aa:Gly,seq:gcc)
     gene            416..492
                     /locus_tag="KNP36_003426"
     tRNA            416..492
                     /locus_tag="KNP36_003426"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:450..452,aa:Arg,seq:tct)
     gene            502..577
                     /locus_tag="KNP36_003427"
     tRNA            502..577
                     /locus_tag="KNP36_003427"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:535..537,aa:Gln,seq:ttg)
     gene            586..661
                     /locus_tag="KNP36_003428"
     tRNA            586..661
                     /locus_tag="KNP36_003428"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:619..621,aa:Lys,seq:ttt)
     gene            664..752
                     /locus_tag="KNP36_003429"
     tRNA            664..752
                     /locus_tag="KNP36_003429"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:698..700,aa:Ser,seq:tga)
     gene            756..831
                     /locus_tag="KNP36_003430"
     tRNA            756..831
                     /locus_tag="KNP36_003430"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:789..791,aa:Phe,seq:gaa)
     gene            838..911
                     /locus_tag="KNP36_003431"
     tRNA            838..911
                     /locus_tag="KNP36_003431"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:872..874,aa:Met,seq:cat)
     gene            926..1002
                     /locus_tag="KNP36_003432"
     tRNA            926..1002
                     /locus_tag="KNP36_003432"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:960..962,aa:Ile,seq:cat)
     gene            1020..1096
                     /locus_tag="KNP36_003433"
     tRNA            1020..1096
                     /locus_tag="KNP36_003433"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1054..1056,aa:His,seq:gtg)
     gene            1105..1180
                     /locus_tag="KNP36_003434"
     tRNA            1105..1180
                     /locus_tag="KNP36_003434"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1138..1140,aa:Lys,seq:ttt)
     gene            1188..1261
                     /locus_tag="KNP36_003435"
     tRNA            1188..1261
                     /locus_tag="KNP36_003435"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1220..1222,aa:Cys,seq:gca)
     gene            1269..1345
                     /locus_tag="KNP36_003436"
     tRNA            1269..1345
                     /locus_tag="KNP36_003436"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1303..1305,aa:Arg,seq:acg)
     gene            1358..1433
                     /locus_tag="KNP36_003437"
     tRNA            1358..1433
                     /locus_tag="KNP36_003437"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1391..1393,aa:Val,seq:tac)
     gene            1509..1922
                     /locus_tag="KNP36_003438"
     CDS             1509..1922
                     /locus_tag="KNP36_003438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009887782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875267.1"
                     /translation="MYIVIGNEIVDSEELKIIIDKNSEFKVEKDLSKSTKREDVIAYQ
                     LSIDLNYLDSLINEQCNLASLSDEEKFDEYMTLSDELALDLEELMPKYTIINARAYKL
                     DEVDGIVKIILAVAYADLGHLKLSDVVKRLSRQVD"
     gene            2231..5662
                     /locus_tag="KNP36_003439"
     CDS             2231..5662
                     /locus_tag="KNP36_003439"
                     /EC_number="6.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate carboxylase"
                     /protein_id="HBF0875268.1"
                     /translation="MLKKFNKILVANRGEIAIRIFRACSELGIKSVGIYSKEDKYGLF
                     RTKADESYLIGEGKGPIDAYLDMDGIIDLAKRKKVDAIHPGYGFLAENAEFARKCEEN
                     GITFIGPSSKVMNMMGDKINSKKIAKEVNVQTIPGVEKAIRSTEEAKEVANKIGYPVM
                     IKASNGGGGRGMRIVHREEDLELEYETACSESRKAFGEDIIFIEKYIADPKHIEVQIL
                     GDNYGNIVHLYERDCSVQRRHQKIIEYAPAFSLDDKVRKEICEDAVKLSKHVGYSNAG
                     TLEFLVDANGGHYFIEMNTRVQVEHTVTEMVTGIDIVQSQILIAQGYSLDSEEINIKS
                     QDDVEIRGYSIQCRITTEDPKNKFMPDTGKIQVYRTGSGFGIRLDGGNGFTGANISPH
                     YDSLLVKTISWDRTFQGAINKTIRSIKELRVRGVKTNVGFLVNVLNNPIFSNGKCSTK
                     FIDENPDLFEITESKDRGTKLLQFIGDVIVNDNACKEKPLFDALHDPRMDKDGSKSEG
                     SKILFDKLGKSAYIEKIKNDKKLLLTDTTMRDAHQSLLATRIRTYDLLKAAKPTEKYQ
                     KDLFSLEMWGGATYDVAYRFLKESPWRRLQKLREEIPSIMFQMLLRASNGVGYKNYPD
                     NVIEEFTRESARQGIDVFRIFDSLNWVENMKPSINTALETGKIVEATMCYTGDILDKT
                     KTKYNLEYYIKMAQELESLGADIIAIKDMSGLLKPYSAYTLVKELKKNVKAPIHLHTH
                     DTSGNGVATCLMASEAGVDIIDAALESMAGLTSQPSLNAIVEALKNTERDTGIDLFGY
                     DELGKYYKDLRKVYNKFESDLTNSCAEIYNFEIPGGQYTNLKPQADSLGLVNRFDEVK
                     EKYKEANEVVGDIIKVTPSSKVVGDLAIFMTKNKLDKDNIIEEGKNLSFPDSVVDYCK
                     GMIGQPEGGIPKDLQEVVLKGEEAITVRPGSLLPAEDFDEIAKYLNEKYDINANIRNV
                     ISYALYPKVYEDYIKHLQHYNDISKLESDVFFYGLNKNEECEVEIEEGKVLTIRLVEI
                     GEVKENGFRTIGFELNGMVREVEIKDKNFSGKINNVEKADMNDPLQIGASIPGKVIKI
                     MVKEEDEVKANQPLIVIEAMKMETIIVAKTDGVIKSIKVKEDDMVEDKQLLMIMK"
     gene            5904..7832
                     /locus_tag="KNP36_003440"
     CDS             5904..7832
                     /locus_tag="KNP36_003440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009904742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HBF0875269.1"
                     /translation="MKVYDSKMLRNVAVLGHSGCGKTNLIETIAYTANTNKIPKLTDK
                     VNMTYSMGLIPIEYNDYKFNLLDTPGYFDFSGDVVSSLRASDAAIIVIDATAPIQVGT
                     EKSLELTESIPKIMFINKIDNEKARYKDAIAMLREKYNNKIVPMISPIYKDKNFVKLH
                     NVFENIDDLEGEFKEQAMSVKEALMELIAETDDQILDKYFNGEELTTEEIQKGIIIGI
                     QRGDIIPVICGSTINNIGTKEILDTISSYLEPIFTEESKPFRGLVFKTMVDPFVGKMS
                     YIKITEGVLSKDKDVFNINKNVKEKIANIYTLRNSELVEIEKAKAGDIVVITKVNSLK
                     TGDTISADKDAEALEKIDFPKPQIYYAVTPKNKGDEEKVASVLNKLVEEDPTLHWYRN
                     TETKQALLGGQGELHIKTIKNKMKDKFGVDVELNDLKVPYRETIKGTADVQGKHKKQS
                     GGHGQYGDVKIRFERCESDFEFTEEIFGGSVPKQYIPAVEKGLKDSMQKGILAGYPVT
                     NIKATLYDGSYHDVDSSEMAFKMAASAAFKKGMEEAHPILLEPIMKLKITVPEEYMGD
                     VMGDINKRRGKIFGMEPDDKGKQIIFAEAPQAETFKYAIDLRAMTQGRGYFEMELERY
                     GEVPSQFAEKIIGLATAK"
BASE COUNT         3096 a         1011 c         1590 g         2207 t
ORIGIN      
        1 ccccttccag gtcgccaaaa taaaatgctg gtgtggctca acggtagagc agctgacttg
       61 taatcagcag gttgtaggtt cgattcctat caccagctcc atataaaatt aatacggagg
      121 atttcccgag cggccaaagg gggcagactg taaatctgtt gtcatcgact tcggtggttc
      181 gaatccacca tcctccacca aaaaaatgcg cggatgtggc ggaattggca gacgcactag
      241 acttaggatc tagcgccatt ggcgtggggg ttcgactccc ttcatccgca ccatttttat
      301 ttaatttaat aaacgagcgg gaatagttca gtggtagagc gcaaccttgc caaggttgaa
      361 gtcgcgagtt cgaatctcgt ttcccgctcc aaattttatg tttatgttgt aatgtgggtg
      421 catagctcag ctggatagag caacgccctt ctaaggcgtg tgtccggggt tcgaatccct
      481 gtgcgctcac cacatatata ttggggatta gccaagtcgg taaggcacat gactttgact
      541 catgtatgcg taggttcgag tcctgcatcc ccagccaaac agtatggtct attagctcag
      601 tcggtagagc acctgacttt taatcagggt gtcccgcgtt cgagtcgcgg atagatcacc
      661 aatggagagg tgtccgagtg gtttaaggag ctggtcttga aaaccagtga cttcgaaagg
      721 ggccgtgggt tcgaatccca ccctctccgc caaatgccca gatagctcag tcggtagagc
      781 aggggactga aaatccccgt gtcggtggtt cgattccgcc tctgggcacc aaaatgtggc
      841 ggtatagctt agttggctag agcgttcggt tcatacccga aaggtcatag gttcgactcc
      901 tattaccgct actgaaattt aatgtgggcc attagctcag ttggttagag cgcccggctc
      961 ataaccggta ggtctggggt tcgagtccct gatggcccac cacattaaat taacttatgg
     1021 tgggtatagc tcagttggtt agagcgccag attgtggctc tggaggtcgt gagttcgact
     1081 ctcattatcc accccaactt atatggtcta ttagctcagt cggtagagca cctgactttt
     1141 aatcagggtg tcccgcgttc gagtcgcgga tagatcacca aaaaggcggc gacatagcca
     1201 agtggtaagg cagtggactg caactccttg atccccagtt cgaatctggg tgtcgcctcc
     1261 aataaaatgc gctcatagct caactggata gagtgtctga ctacgaatca gaaggttagg
     1321 ggttcgagtc cctttgggcg caccatatga atagcgaggg attatagctc agctgggaga
     1381 gcacctgcct tacaagcagg gggtcacagg ttcgagccct gttaatccca ccagtgcaaa
     1441 cctctagtaa aactactaga ggttttattt ttgattgaaa aagtttttat atttaggagg
     1501 taaaaaattt gtatatagta ataggaaatg aaatagttga tagtgaagaa cttaaaataa
     1561 ttatagataa aaatagtgaa tttaaagttg aaaaagattt aagtaaaagc acaaaaagag
     1621 aagatgtaat agcatatcag ttaagtatag atttaaatta cctagattct cttataaatg
     1681 agcaatgtaa tttagccagt ctatctgatg aagagaaatt tgatgaatat atgactttgt
     1741 ctgatgaact tgcactggat ttagaagagt taatgccaaa atatacaata ataaatgcta
     1801 gagcatataa attagacgag gtagatggaa ttgtaaaaat aatactagct gtagcgtatg
     1861 cagatttagg gcacttgaaa ctttctgatg tagtaaagag gctatctaga caagtagatt
     1921 aggatatgaa tatgaactat attaaaaaaa tgtataaaat cttacgtaaa gatgaaaata
     1981 attatgtaaa catagaaaaa aacagtataa aatcaagtca attgtagaaa ttttcacata
     2041 aattcatctg aaattctata aaaaatgcct taattttaat gaggtaaatc gagtttacac
     2101 agtctaaaaa ttacttatat ttataaattt atcttattaa ttaaggaact ttcttaaaca
     2161 tcttcaaaaa taaagtattt tagtctataa tctttaatat tacacaaaca ataaaggaga
     2221 agaatagagt atgcttaaaa agtttaataa aatactagtg gctaatagag gcgaaatagc
     2281 tataagaata tttagagcct gttcagaatt ggggataaaa agtgttggta tatacagtaa
     2341 ggaagataag tatggattgt ttagaacaaa agcggatgaa tcatatttga taggagaagg
     2401 taaagggcca atagatgcat atttagatat ggatggaata atagacctag caaagagaaa
     2461 aaaagttgat gctatacatc caggatatgg ttttctagcg gagaatgcag aatttgctcg
     2521 taaatgtgaa gagaatggaa ttacttttat aggaccatca tctaaggtaa tgaatatgat
     2581 gggggataag attaactcta aaaaaatcgc aaaagaagtt aatgttcaaa ctataccagg
     2641 agtagaaaaa gcaataagaa gtactgaaga agcaaaggaa gttgcaaaca aaataggata
     2701 tcctgttatg ataaaagcat ctaatggcgg tggcggtaga ggtatgagaa ttgtacatcg
     2761 cgaagaagac ttagagcttg aatatgaaac tgcttgtagt gaatcaagaa aagcttttgg
     2821 agaagatatt atatttatag aaaaatatat agctgatcca aaacatatag aagttcaaat
     2881 attaggtgat aattatggaa atatagttca cttatatgaa agagattgtt cagttcaaag
     2941 aagacatcaa aaaataatag aatatgcacc agctttttca ttagatgata aagtaagaaa
     3001 agagatatgt gaagatgcag ttaagttatc aaaacatgtg ggttattcta atgcgggaac
     3061 attagaattt ttagtagatg caaatggtgg gcattatttt atagagatga acacaagagt
     3121 acaggttgaa catactgtaa cagagatggt tacaggaata gatatagttc aaagtcaaat
     3181 actaatagcc caaggttaca gcttagatag tgaagaaatt aatataaaat cacaagatga
     3241 tgtggaaata agaggttact ctatccaatg tagaataact acagaagacc ctaagaataa
     3301 attcatgcct gatacaggta aaattcaagt ttatagaact ggttcaggat ttggtataag
     3361 actagatgga ggaaatggat ttacaggggc aaacataagt cctcattatg atagtttatt
     3421 ggttaagaca atatcttggg atagaacatt ccaaggagca ataaataaaa ctataagatc
     3481 tataaaagaa cttagagtta gaggtgttaa aactaatgta ggattcctag ttaatgtttt
     3541 aaataatcct atattctcaa atggtaaatg tagtactaag tttatagatg aaaatccaga
     3601 tttatttgaa ataacagaaa gtaaagacag aggaacaaaa ttacttcaat ttataggaga
     3661 tgtaattgta aatgataatg cttgtaaaga aaaaccatta tttgatgcat tacatgaccc
     3721 aagaatggat aaggatggtt caaaatcaga aggaagtaaa atacttttcg ataagttagg
     3781 taaatctgca tatatagaaa agataaaaaa tgataagaaa ttactattaa cagatacaac
     3841 aatgagagat gcacatcaat cattattagc aacaagaata agaacatatg acttattaaa
     3901 agctgctaag ccaacagaaa aatatcaaaa ggatttattc tcacttgaaa tgtggggagg
     3961 agctacttat gatgttgcat atagattttt aaaagaatct ccttggcgta gattacaaaa
     4021 gctaagagaa gaaataccaa gcataatgtt ccaaatgttg cttagagcat caaatggagt
     4081 tggatataaa aactatccag ataatgtaat agaagaattt acaagagaat ctgctagaca
     4141 aggtatagat gtatttagaa tatttgattc attaaactgg gttgaaaata tgaaaccatc
     4201 tattaataca gctttagaaa ctggaaaaat tgttgaagca actatgtgtt atacaggtga
     4261 tatactagat aagactaaaa ctaaatacaa tctagaatat tatattaaaa tggcacaaga
     4321 attagaaagc ttgggagcag atataatagc aataaaagat atgtcaggtc ttcttaaacc
     4381 atattcagct tacacattag ttaaagagtt aaagaaaaat gtaaaagcac caatacattt
     4441 acacactcat gatacaagtg gaaatggtgt agcaacttgt ttaatggcgt cagaagctgg
     4501 agtagacata attgatgctg cattagaatc tatggcagga cttacaagtc agccatcact
     4561 taatgctata gtagaggcac ttaagaatac agagagagat acaggaatag atttatttgg
     4621 atatgatgag ttaggaaaat attataagga tttaagaaaa gtttataata aatttgaaag
     4681 tgatttaact aattcttgtg cagaaatata taattttgaa ataccaggag gccaatatac
     4741 aaacttaaaa cctcaagctg atagtttagg attagttaat agatttgatg aagttaaaga
     4801 aaaatataaa gaagctaatg aagttgtagg agatataata aaagtaactc catcttcaaa
     4861 agttgtagga gacttagcta tctttatgac taaaaataaa ttagataaag acaatataat
     4921 agaagaaggt aaaaatttat cattcccaga ttctgttgtg gattactgta aaggtatgat
     4981 tggtcaacca gaaggtggaa taccaaaaga tttacaagag gtagttctaa aaggtgaaga
     5041 agctataaca gtaagaccag gttcattatt accagcagaa gattttgatg aaatagctaa
     5101 atatctaaat gaaaagtatg atataaatgc taatataaga aatgttataa gttatgcttt
     5161 atatccaaaa gtatatgaag attatatcaa acatctacaa cattataatg atatatctaa
     5221 acttgaaagt gatgtattct tctatggatt aaataaaaat gaagaatgtg aagtagaaat
     5281 agaagaaggt aaggtattaa caataagatt agttgaaatt ggtgaagtta aggaaaatgg
     5341 atttagaact ataggatttg agttaaatgg aatggttaga gaagtagaaa taaaagataa
     5401 gaatttctct ggaaaaatta ataatgttga aaaagctgat atgaatgacc ctcttcaaat
     5461 tggagcaagc ataccaggaa aagttataaa aataatggtt aaagaagaag atgaagtaaa
     5521 agcaaatcaa ccattaatcg ttatagaggc tatgaagatg gaaactataa tagttgctaa
     5581 gactgatgga gtaattaagt caatcaaagt aaaagaagat gatatggttg aagataaaca
     5641 attattaatg ataatgaagt aatttaatta aaataaatta aaaagcactc tgaaatgttt
     5701 aataaaaaat gttttagagt gtttttattt attttaatta aatatttgtt aaaaaaaaga
     5761 ggacaattac ctccagatgt agaaataaag ctagtaagga aaatgttatc taaaaattct
     5821 aaatatagta aatattttcc ataatatttc ttaggaaata acagcaaaga taaaatacat
     5881 aaatttaaaa ggtgggtgct tatatgaagg tttatgatag taaaatgttg agaaatgtag
     5941 cggtattagg acatagcgga tgtggaaaaa caaatctaat cgaaactata gcttacacag
     6001 caaacactaa taagatacct aaattaacag acaaggtaaa tatgacttat agcatgggat
     6061 taatacctat agagtataat gattataagt ttaacttatt ggatacccca ggatattttg
     6121 actttagcgg agacgttgtg tcatctctta gagcaagtga tgcagcaata atagtaatag
     6181 atgcaacagc gcctattcaa gttggtacag agaaatcatt agaactaact gagagtattc
     6241 ctaagataat gtttataaat aaaatagata atgaaaaggc aagatacaaa gatgcaatag
     6301 caatgttaag agaaaaatac aataataaga tagttcctat gataagtcct atatacaaag
     6361 ataaaaactt tgtaaagtta cataatgttt ttgaaaacat agatgattta gaaggtgaat
     6421 ttaaggaaca agctatgagt gttaaagaag cattaatgga acttatagca gaaactgatg
     6481 accaaatatt agataaatat tttaatggag aagaactaac tacagaagag atacaaaaag
     6541 gtattattat aggtatacaa agaggtgata ttatacctgt aatatgtggt tcaactataa
     6601 ataatatagg cacaaaggaa atattagata caatatcaag ttatttagaa cctatcttta
     6661 cagaggaaag caaaccattt aggggattag tatttaaaac tatggttgac ccatttgttg
     6721 gaaagatgtc atatataaaa attactgagg gtgtactttc taaggataaa gatgttttta
     6781 atataaataa aaatgtaaaa gaaaaaatag ctaatatata tacattgaga aatagtgaat
     6841 tagtagaaat agaaaaagct aaagctggtg atatagtagt tataactaaa gttaattctc
     6901 taaaaacagg agacactata tctgcagata aagatgcaga agctttagaa aagatagatt
     6961 ttcctaaacc acaaatatat tatgcagtaa ctcctaagaa taaaggtgat gaagaaaaag
     7021 tagcatctgt attaaataaa ctagtagaag aggaccctac attacattgg tatagaaata
     7081 cagagacaaa acaagcactt ttaggaggtc aaggagaact tcatataaaa acaattaaaa
     7141 ataaaatgaa agataagttt ggtgttgatg ttgaattgaa tgaccttaaa gttccttata
     7201 gagaaactat aaaaggaaca gctgatgtac aaggaaaaca taaaaagcaa tcaggtggtc
     7261 atggtcaata tggagacgta aaaataagat ttgaaagatg tgaatctgat tttgaattta
     7321 cagaagaaat atttggtggt tctgtaccaa aacaatatat accagcagtt gaaaaaggtt
     7381 taaaagactc tatgcaaaaa ggtatattag caggatatcc tgttacaaac ataaaagcta
     7441 cgctttatga tggttcatac catgatgtag actcttctga aatggccttt aaaatggcag
     7501 caagtgcagc ctttaaaaaa ggtatggaag aagcacaccc aatactacta gaacctataa
     7561 tgaaacttaa gataactgtt ccagaagaat atatgggaga tgtcatgggt gatataaata
     7621 agagaagagg aaaaatattt ggaatggaac cagatgacaa agggaaacaa ataatatttg
     7681 cagaagctcc acaagcagag acatttaaat atgcaataga tttaagagca atgacacaag
     7741 gtagaggata ctttgaaatg gaattagaga gatatggaga ggttccatca cagtttgcag
     7801 aaaaaataat tgggttagct actgcaaagt aatgaacaaa ataaatagaa aaataattaa
     7861 tatatattat taaaaatatt tttagggttt taactaggta tagg
//
LOCUS       DAEHWM010000136         7837 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.139, whole genome shotgun sequence.
ACCESSION   DAEHWM010000136 DAEHWM010000000
VERSION     DAEHWM010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7837)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7837)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7837
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.139"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     misc_binding    68..279
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            442..1731
                     /locus_tag="KNP36_003441"
     CDS             442..1731
                     /locus_tag="KNP36_003441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine permease"
                     /protein_id="HBF0875270.1"
                     /translation="MEEEKINYALEQIPENQKRGWVAMFSVLVAIGVDLSSVILGAEL
                     AQSMPMKQAILSVIVGSFFSAILYTTCSLVGSSTSLSTSMITKYVFGEAGAKIFSLVI
                     GVSLLGWFGVQVGFFAQNAQIIIKDIFNLDVSMQILSLIGGLLMMSTAIYGYKAMEKL
                     SVYSVPFLLVLMMLTIFLAFRANGISVDDNMKSTMTFAGGVSLSMSIIIVGAIVSPDI
                     SRWAKSRRDCALSSFLGIQFGNAFMIIVSIVLVKCMGTSDIMRIFITLGIAIPGIIVL
                     TLAQWTTNTSNVYSASLSIALVLKKAPEKVLTIVLGIIATLLAVFGIYEGFIGFLNLL
                     GIVIAPVGGVYTAEYYIVKQELKGFDKGVLYKPIVKRSIVSWIIGILITYLSTYGFIT
                     LTTIAPLDGFIAGFVVQSIIGKVLCSTKNKQEIDKAV"
     gene            1785..2864
                     /locus_tag="KNP36_003442"
     CDS             1785..2864
                     /locus_tag="KNP36_003442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF917 domain-containing protein"
                     /protein_id="HBF0875271.1"
                     /translation="MRFLTEESVDKIAVGAAVLGTGGGGDPYVGKLVAKQAIKKYGPV
                     KVISLDELDDDALVVPVSGMGSPVITIEKLLSEVELTTPLEIMEKLLNRKVDVIIPIE
                     IGGINSLMPIAVAAKKGLPILDADSMGRAFPEAQMVTFYLEGYEASPAVMSDEKGNSA
                     ILYPVDGIWSERLARTLTVEMGGSSSISDYNLSGAQVKKAAIGNTLTIAETIGGFLLE
                     NKSDSKGAVENILKELCGYKLFEGKVIDIKRELKGGFTRGHAFFAGINEYDGEYSILF
                     QNENLIAKKGDTPLCITPDLIAVLDLETGFPITTERIKYGSRVMVVAFPCNEKWRTEK
                     GIETVGPGYFGYDVEYKTVEELQGK"
     gene            2885..4429
                     /locus_tag="KNP36_003443"
     CDS             2885..4429
                     /locus_tag="KNP36_003443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020246462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="HBF0875272.1"
                     /translation="MYRVGIDVGGTNTDACILDGELKVIHSVKVATTKDVETGVYNAL
                     KKVIDESKIDHSLIKYAMLGTTHCTNAIVERKRLNNVAMIRIGKPATTAILPFIDWPE
                     DLREKIELDSILVSGGYEFDGRKINELCKDEVVEFCNRIKGKVESVAISGVFAPVNKQ
                     QEEEVAKWVREILGDIPISLSNEIGNIGILERENGAILNSALSQVGKAVSLGFEKALK
                     DLGIDAQIYFSQNDGTLMNLEYTMKYPIFTIGCGITNSIRGASFLSKVKNAIVLDVGG
                     TTSDLGVLYNGFPRESSIPVTIGGVHTNFRMPDVLTIGLAGGTCVKGEKDNIKIGPES
                     VGYRITEDAIIFGGDTLTLSDVVTKLDMAFEDRKSNVENLDKEYCNEVYKKVILKLED
                     AVDQMKTSQDDVELVLTGGGSIIVPEKLKGISNVIRPPHYTAANAIGAALGQISGDVE
                     KVYSLDKMSREDAIEDAKKEAVNKALKAGAKEDTIEVLNIEDVPLAYLPGNALLIKVK
                     VVGDLI"
     gene            complement(4592..5134)
                     /locus_tag="KNP36_003444"
     CDS             complement(4592..5134)
                     /locus_tag="KNP36_003444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
                     /protein_id="HBF0875273.1"
                     /translation="MKSYIALLRGINISGKNKIIMSELKASFVELGYSEVSTYLNSGN
                     VVFLSDVDDSKVISNTIRLMIKKQFELEIPVFIISQEELKDILNNAPNWWGDNNKEIY
                     DNLIFMFPDLSYDEFYDEVGNPKEEYEKVYHYKNAIFWSFSRKDYKKTNWWSKTASSN
                     VSDKITIRTANTVRKIVGMR"
     gene            complement(5282..5566)
                     /locus_tag="KNP36_003445"
     CDS             complement(5282..5566)
                     /locus_tag="KNP36_003445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBF0875274.1"
                     /translation="MAKNTKQTTVHIDETLLKEVKRIGINENKSISQIINESIIDYIL
                     VYRENEDKEKNEHDKNLNETINEFKKEEEKRMQAKSAARAIAEAKKRVLY"
     gene            complement(5629..6393)
                     /locus_tag="KNP36_003446"
     CDS             complement(5629..6393)
                     /locus_tag="KNP36_003446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HBF0875275.1"
                     /translation="MNNYLKFATYQLIGFTSSIPRLIKIKKNPDKFSLKEKFEFMQKQ
                     AKKSLDIVNIELNIIGKETLPKEPLLFVVNHSSMLDSFILTASVERPIGCVIADEPVW
                     RNIPIFKEWAKLLRCVYVNRKNNREGIKSIAQASQNILTGQSMAVFPEGDLTWIKEPN
                     SLVSEFRSGALKIAYKAKCPIVPLVIKNSKDTYEGYQPIGKINSVPVEVEFLEPIYDH
                     IENPRLKSSVLGENIKNKMINTIENFRKSNKTFKEF"
     gene            complement(6675..6941)
                     /locus_tag="KNP36_003447"
     CDS             complement(6675..6941)
                     /locus_tag="KNP36_003447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3795 domain-containing protein"
                     /protein_id="HBF0875276.1"
                     /translation="MIESRCGILCYECGYKEKVNCKGCTEIEKPFWGEQCPVKSCCED
                     KNLTHCGLCDTFPCEMLNQFAYDKEQGDDGKRISQCKKWAVLAL"
     gene            complement(6983..7792)
                     /locus_tag="KNP36_003448"
     CDS             complement(6983..7792)
                     /locus_tag="KNP36_003448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875277.1"
                     /translation="MNKIINNILNTCKQYTYILPHKLLRQYIAHYTISIPDTSIKENL
                     TLIPDASGCMIFKFDKKGIESAFWGATTKTTIVKNDIENVLFRVFVEFRPGGVYYLTG
                     LSQRESTDLKISLEDFNTLFSLEVNSIFERTSTIKELVEQLDMLFLSYLLKSNIVDMT
                     IPILENARKQNSIMSVKNISQISCYSERHLNRIFNNSLGMSVKSYLRLLRINLVLQEI
                     QNNKIPFATLAQDIGYYDQSHFINDFKSICGVNPTTYIKNLSDFYNEKYKF"
BASE COUNT         2725 a          996 c         1280 g         2836 t
ORIGIN      
        1 ttttaagttg acaaaatatt gcatatatat tatgatataa atcataaatt aactacaaat
       61 caatattata tattcgtaga agaagaaagt agcataaagg aattttacag agagttagat
      121 ttggctgaga actaatattg gaatttatgt gaaaaggact ttggagaata ctattgtaat
      181 tatgttagaa tagtggttta attcgcctta agaaaatgag tgagtaaaat taatttttac
      241 taataagagt ggtaacacgg atttatattc gtctcttgga tttttccaag aggcgttttt
      301 tattataaac ttatttcaga aaatttaaaa ctatatatta aatgaaaatt ataaaaatat
      361 gatagttaat aaatttataa attagaaaat tgtaaaatat gctaaggtca gtagttttac
      421 gatttaaatg gagggatgaa aatggaagaa gaaaaaatta actatgctct ggaacagatt
      481 ccagagaatc aaaaacgtgg ttgggtagct atgttttcag ttttagtagc aataggtgtg
      541 gatttatcat ctgttatttt aggcgctgag ttggcacaga gtatgccaat gaaacaagca
      601 atattgtcag taattgttgg ttcatttttt tctgcaattt tgtatactac atgctctttg
      661 gttggttcat ctacaagttt atctacatct atgataacaa agtatgtatt tggagaagct
      721 ggagcaaaaa tattttctct agttataggg gtttctctat taggttggtt tggagttcaa
      781 gtaggtttct ttgctcaaaa tgcacagata ataataaaag atatatttaa tttagatgtc
      841 agtatgcaga ttttaagcct aataggtggt ctcttgatga tgagtactgc aatttatgga
      901 tataaggcaa tggagaagtt gagtgtgtat tcagtaccat ttttattagt tcttatgatg
      961 ctaactatat tcttagcttt tagagcaaat ggaatttcag ttgatgataa tatgaaatct
     1021 actatgacat ttgcaggtgg agtttctctg tcaatgagta taataatagt tggtgcaatt
     1081 gtatctcctg atataagtcg ttgggctaaa agtagaagag actgtgctct ttcaagcttt
     1141 ttgggaatac aatttggaaa tgcttttatg ataatagttt cgatagtatt agtaaaatgt
     1201 atgggaactt cagatattat gagaattttt attacattag gaattgctat accaggtata
     1261 atagtactta cattagcaca atggactaca aatacaagta atgtatattc agcatcatta
     1321 agtatagctc ttgtacttaa gaaggctcct gagaaagtat taactatagt ccttggtatt
     1381 atagcaacat tattggctgt atttggaata tatgaaggtt ttataggatt tttaaattta
     1441 cttggaattg taattgcacc tgttggtggt gtatatacag cagaatatta catagtaaag
     1501 caagaactta aaggctttga taaaggagta ttatataaac caatagttaa acgttcaata
     1561 gtgtcttgga taattggtat attaataact tacctttcaa catatggatt tataactctt
     1621 actactatag cacctttaga tggttttata gcagggtttg tagtacaatc tattattgga
     1681 aaagtgcttt gttcaacaaa aaataagcaa gaaatagaca aagcagtata aagaaatttg
     1741 tttataaagt ataaaataaa ttagaaatat gaggagaaag taacatgaga tttttaacag
     1801 aagaaagtgt agataaaata gcagttggtg cagcagtgct tggaactgga ggtggaggtg
     1861 acccatatgt aggtaaattg gttgcaaaac aagccattaa aaagtatggt cctgtaaaag
     1921 taataagttt agatgaactt gatgatgatg ctttggtagt tccagtatct ggtatgggtt
     1981 ctcctgtaat tacaatagaa aaattacttt cagaagtaga gttaactacc cctttagaaa
     2041 taatggagaa attattaaat agaaaagtgg atgttataat tcctatagaa ataggaggga
     2101 taaactcact tatgcctata gcagttgctg ctaaaaaagg acttcctatc ttagatgcag
     2161 attctatggg tagagctttc cctgaagctc aaatggtaac tttttatctt gaaggatatg
     2221 aggcatctcc tgccgtaatg tctgatgaaa aaggtaattc tgccatcctt tatcctgtgg
     2281 atggaatttg gtcagaaaga ttagctagaa ctttaactgt agaaatggga ggaagttctt
     2341 ctattagtga ctataattta agtggagctc aagttaaaaa agctgctata ggtaatactc
     2401 ttacaatagc tgaaactata ggagggtttt tacttgaaaa taaatctgat tcaaaaggtg
     2461 ctgttgagaa tatactaaaa gaattgtgtg gatacaagtt atttgaagga aaagtaattg
     2521 atattaagag agagttgaaa ggtggattta ctagaggaca tgcctttttt gctgggatta
     2581 atgagtatga tggagagtat tctatattat tccaaaatga gaatttaatt gccaaaaaag
     2641 gtgatacacc actttgtatt acaccagatt taatagcagt attagattta gaaactggat
     2701 ttccaataac tacagagaga ataaaatatg gctctcgtgt tatggtagta gcttttcctt
     2761 gtaatgaaaa atggagaaca gaaaaaggaa ttgagacagt tggacctgga tactttggat
     2821 atgatgtgga atataaaaca gtagaagaat tacaaggaaa ataaaagttt aggaggaaat
     2881 tttgatgtat cgtgtaggaa ttgacgttgg aggaacaaat acagatgctt gtatactgga
     2941 tggggaatta aaagtaattc attcagttaa ggtggcaact acaaaagatg ttgaaactgg
     3001 tgtttacaat gccttaaaaa aagttataga tgaaagtaag attgaccatt cattaataaa
     3061 atatgctatg cttggtacaa ctcattgtac aaatgctatt gtagaaagaa aaagacttaa
     3121 taatgtggct atgataagaa taggaaagcc ggccactact gccattcttc catttataga
     3181 ttggccagaa gacttaagag aaaaaataga attagattca atattggtat ctggtggata
     3241 tgagtttgat ggcagaaaaa taaatgaact ttgtaaagat gaagttgtag agttttgcaa
     3301 tagaataaaa ggcaaagtgg aaagtgttgc aataagtgga gtatttgctc cagtaaataa
     3361 acaacaagaa gaagaagttg caaaatgggt tagagaaatt ttaggggata ttcctatatc
     3421 tttatcaaat gaaataggta atataggtat attagaaaga gaaaatggag ctattttaaa
     3481 ttctgcattg tctcaagtag gtaaagctgt atctttagga tttgaaaaag cacttaaaga
     3541 tttaggtata gatgctcaaa tatatttcag tcaaaatgat ggaacattaa tgaatttaga
     3601 gtatacaatg aaatacccaa tttttacaat tggatgtgga ataacaaatt ctataagagg
     3661 agcttccttc ttatcaaaag taaaaaatgc aatagtatta gatgttggtg gaactacaag
     3721 cgacttgggt gtactatata atggattccc tagagaatca tctattccag ttacaattgg
     3781 aggagtacat acaaacttta gaatgccaga tgttttaact attggtcttg ctggtggtac
     3841 atgtgtaaaa ggcgaaaaag ataatataaa gataggtcct gaaagtgtgg gatatagaat
     3901 aactgaagat gcaataatat ttggtggaga cactctaact ttatcagatg ttgttacaaa
     3961 attagatatg gcgtttgaag atagaaaaag caatgttgaa aacttagata aagagtattg
     4021 taatgaggta tataagaagg ttattttaaa attagaagat gctgtagacc aaatgaagac
     4081 tagtcaagat gatgttgaat tggttttaac tggtggagga agtataattg ttcctgaaaa
     4141 actaaaaggc ataagcaatg ttataagacc tcctcattat actgctgcaa atgctattgg
     4201 tgcagcttta ggacaaataa gtggagatgt agaaaaagta tacagtttag ataaaatgtc
     4261 gagagaagat gccatagaag atgcaaaaaa agaggctgta aataaagctc taaaagctgg
     4321 tgctaaagaa gatactatag aagtattaaa tatagaagat gttccacttg cataccttcc
     4381 tggtaatgca cttcttataa aagtaaaagt tgttggtgat ttaatttaaa gaataaatat
     4441 aagtatttcc agaattatat aaatatttct ggactcattt ttaaacttat tttatcaata
     4501 aaaacagcat aacttttgac tatattctta taagtttccg aacagccgat atatacctat
     4561 tttttgaggt ttatcggctg tttgttatct tttatcgcat tccaactatt tttcttaccg
     4621 tatttgctgt acgaattgta atcttatcac ttacatttga actggcagtc tttgaccacc
     4681 aatttgtctt tttataatct ttacgactaa aagaccaaaa gatagcattt ttataatgat
     4741 atactttttc atactcttct ttaggatttc caacctcatc ataaaactcg tcataagata
     4801 agtcaggaaa cataaaaata agattatcat atatttcttt gttgttatct ccccaccaat
     4861 taggagcatt atttagtata tcttttaact cttcttgtga aataataaaa actggtattt
     4921 ccaattcaaa ctgttttttt atcattaatc ttattgtatt tgagataacc ttgctgtcat
     4981 ctacatcact taaaaagaca acattaccac tattaaggta tgtagaaact tctgaataac
     5041 caagttctac aaagcttgct tttaattcag acataattat cttgttctta ccacttatat
     5101 tgatacctct taataatgcg atataacttt tcatataata atttcacctc taaacattca
     5161 catttttcta tgtagtacaa acttgaattt gcatctttta taattctttc aaaacttctt
     5221 catatgtaat ttttttaata taaaaaaatc ggtgcttaat ttgtaccgat ttttgttttt
     5281 cctagtaaag aactcgtttt tttgcttctg ctatagctct agcagcactt tttgcttgca
     5341 ttcttttttc ttcttctttt ttaaattcat ttattgtttc atttagattc ttatcatgtt
     5401 catttttttc tttatcttcg ttttctctgt atactaatat ataatctatt attgattcgt
     5461 ttattatctg agatatactt ttattttcat taattcctat tctcttaact tccttaagta
     5521 gagtctcatc aatatgaacc gttgtttgct ttgtattttt tgccacctta atcacctctt
     5581 aaaaaaaatt ctaacattaa aatttttttt agtcaataaa ttttaatatt aaaattcttt
     5641 aaatgtttta tttgattttc taaaattttc tattgtattt atcatcttat tttttatatt
     5701 ttcacctagt acagaagact ttagtctagg attttcgata tggtcataaa ttggttctaa
     5761 aaattcaact tcgacaggaa cagagttaat tttaccaata ggttggtatc cttcataagt
     5821 atcttttgaa ttttttatta cgagtggaac aatagggcat tttgctttat atgctatctt
     5881 taaagctcca cttctaaact ccgaaaccaa tgaatttggt tctttaatcc atgttaaatc
     5941 tccttctgga aacactgcca tactttgacc tgtaagtata ttttgagagg cttgggctat
     6001 actctttata ccctcacgat tgttttttct gtttacatat acacatctta gtaattttgc
     6061 ccattcttta aatataggta tatttctcca aactggttca tctgcaatta cacatccaat
     6121 tggtctttct acacttgctg ttagtatgaa gctgtcaagc atactagaat gatttacaac
     6181 aaatagaagt ggttcttttg gcagtgtttc cttaccaatt atattaagct ctatattcac
     6241 tatatctaaa gattttttag cttgtttttg cataaattca aatttttcct ttaagctaaa
     6301 tttatcagga ttctttttaa ttttaataag cctaggtata gaagatgtaa aacctataag
     6361 ttgatatgta gcaaatttta agtaattatt cataaaatta tctccttaaa ataaaattat
     6421 ttattactgt aaagatttta acataaaata aaatttaagt ctattttaat tcaattttgt
     6481 aacatatatt ttaaatagac agagattgag attttatatt tccaatttta gtaatcagat
     6541 tttatcaata aattactatt ctattaattt aattaaataa cctttaaatt taattataaa
     6601 aactgttgca gaaatttcta caacagttta aaaaatttac cttacaaaaa cttattttat
     6661 aacaagagag tatattataa ggctagtaca gcccattttt tgcactgaga aattcttttg
     6721 ccatcatcac cttgttcttt gtcatatgca aattgattaa gcatttcaca tggaaatgta
     6781 tcacatagac cacaatgtgt aaggttttta tcttcacaac aagattttac aggacattgt
     6841 tcaccccaaa atggtttctc aatctctgta caacctttac aattgacttt ttccttgtat
     6901 ccacattcat aacataaaat tccacatctt gattctatca ttttaagtca ctccttaaat
     6961 ataaatttta tatgattgta tatcaaaatt tatacttttc attgtaaaaa tcggacaaat
     7021 tttttatata ggttgttgga ttaacaccac aaatagattt aaaatcattt ataaaatgag
     7081 attggtcgta ataaccaata tcttgtgcta aagttgcaaa tggtatttta ttattttgta
     7141 tttcttgtaa tacaaggttt atacgaagta atctaaggta tgatttaaca ctcataccaa
     7201 gagaattatt aaaaattcta tttaaatgtc gttcactata acaactaatt tgtgaaatgt
     7261 ttttaacaga cataatagag ttttgttttc tagcattttc aagaattggt atagtcatat
     7321 ctactatatt tgatttcaat aagtatgata agaataacat atctaattgt tctactaatt
     7381 cctttatagt acttgttctt tcaaaaatgg aattaacctc taagctaaat aatgtgttaa
     7441 aatcttcaag tgaaattttt aaatctgtag attctctttg agaaagacct gtcaaataat
     7501 atactccacc tgggcgaaac tcaacgaata ctctaaaaag tacattttct atatcatttt
     7561 ttacaatagt agtttttgtt gtggctcccc agaatgcgct ttctatacct tttttgtcaa
     7621 atttaaatat catacatcca ctagcatcag gtattaatgt aagattttct ttaatacttg
     7681 tatctggaat agatattgta tagtgtgcta tatactgtct taacaattta tgtggcaaaa
     7741 tatatgtata ctgtttgcag gtatttaaaa tgttattgat tattttattc ataagtatat
     7801 cctcctgata tataaaaaat aagtatacta atttatt
//
LOCUS       DAEHWM010000137         7829 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.140, whole genome shotgun sequence.
ACCESSION   DAEHWM010000137 DAEHWM010000000
VERSION     DAEHWM010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7829)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7829)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7829
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.140"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..1548)
                     /locus_tag="KNP36_003449"
     CDS             complement(<1..1548)
                     /locus_tag="KNP36_003449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HBF0875278.1"
                     /translation="MDNIISVLNDVVFLDIEVSGLDCLNSEILEVGAVKVKDWKIYTY
                     ESLIKNKFEVPIEVFSVCKNLDKNDLEIANKIELVEDRLVNFVEDSFIICHDLSLKKK
                     FFEYHMPKLKNKFIDLIELAVILEPYHKDYSLEYLKNTLTNCNSKVENRALSDAIDII
                     NIVNCLLVKFNNYEKTTLEPLSFKINSYLKKFNLPTWEWSKFLEEANYDLSNNINIKK
                     EYNIFDSKEEKKKERETLKILNEEEKNYEELLKYKTIWENKEGFTYEYRPGQYELTKT
                     IRELFRNSEDEEKIACIEAPTGIGKSVGYLLPAILEARINKKRLLISTDTKELQIQLI
                     NKDIPNVLDSLGLNGKVSYGYIKGKNNYICIDRLEAYIDDYESQNPTKGEILSLIFLK
                     RLVEGGKYGDIEEINYLVFDNFKEISTHLRNVSCDPNMCRPKKCKKDCLYKNRIEELK
                     EEHITVVNHSLLAKWPYKDEKPLENIIVDEAHNLTEKGYDFFSSIINSKSLRYLLQEI
                     YPYEFIQN"
     gene            1769..2593
                     /gene="pdaA"
                     /locus_tag="KNP36_003450"
     CDS             1769..2593
                     /gene="pdaA"
                     /locus_tag="KNP36_003450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="HBF0875279.1"
                     /translation="MKKDSLKKYIMIGAFALTLFGIASINFKSLDKTKTQISSPTLDT
                     HEYDWYFNPREDGKQPSPIKEADFFKKYGAYYVGNPNEKVIYLSFDAGYESGNTPKLL
                     DTLKKHNAKAQFFVVESYIKSNPELIKRMEKEGHLVCNHSKSHPSMAGITDFEKFKEE
                     ITSVEKAYKDVTGKEMPKYFRPPMGKFSEQSLKYTQDLGYKSIFWSFAYVDWYEKKQP
                     THEFAKNKIYSRTHPGAIVLLHPNSSTNTEILDEVLTHWEKEGYKLKTLDYLNNKK"
     gene            complement(2690..3475)
                     /locus_tag="KNP36_003451"
     CDS             complement(2690..3475)
                     /locus_tag="KNP36_003451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0875280.1"
                     /translation="MIVKIDNTLEKEFWQYVSHEESLNLFIIGYVENYGFSSQYQDIW
                     SQVEGGNITSIILKNKSTLIIYSFKNNFNIGEMKNHIKDLDVESISGKKCVIDRLISK
                     YKDFYEKLDNKFCVLKEIKEIDFSNMKEYKIENAQEKDIDEIGKLLNRSDYKVSKNYI
                     EERKVHLKEGNVRAYFIRNDDTMISTVSTGMETSFLAMVVSVSTDKRYRGKGLASYMV
                     YNLSKELLLEGKVPCLFYNNDVAGKIYHNIGYKEINEWTILFK"
     gene            3940..4305
                     /locus_tag="KNP36_003452"
     CDS             3940..4305
                     /locus_tag="KNP36_003452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875281.1"
                     /translation="MKIRAEYTCPLEIVHDIIKGKWKTILIFELRQSNKTFSELQHNI
                     YGINQKMLIQQLKELRDFGIIDKISSAGYPLHVEYFLTNRGKKMLKAVEIMQEIGIEY
                     MLEHGQQEILDNKGICYNK"
     gene            4383..4937
                     /locus_tag="KNP36_003453"
     CDS             4383..4937
                     /locus_tag="KNP36_003453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HBF0875282.1"
                     /translation="MSIALILIDIQNDYFKNGKCELFQSEETAENAKKILLFFRKNNL
                     PVIHIQHISTDKTASFFLPNTHGSEINKIVFPLDNEEIIIKHTPDSFFETDLQSILEK
                     KNITNLVICGMMSHMCIDTSVRTAKKLRYDITLISDACTTKNLSWNNIEINANTVHQV
                     FMASLQNSFADVKNTDKFLSNYYK"
     gene            5157..5831
                     /locus_tag="KNP36_003454"
     CDS             5157..5831
                     /locus_tag="KNP36_003454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HBF0875283.1"
                     /translation="MNHHILIQFEYIARIITAGFCGALIGYERKNRLKEAGIRTHFIV
                     ALASALIIIVSKYGFNDIVGTPGIGLDPARVAAQVVSGIGFLGAGLIFIRNQSVSGLT
                     TAAGIWATAGTGLAIGSGLYLVGIVSSIIIVIVQITLHRDRKWMKLPTAEQVSLKISN
                     STDSIEYIEGKFKKSNIEIINMNIKRLDGDWLEVVIYTKLPKGYKKTNLLKLFSDNPL
                     IETLEI"
     regulatory      6186..6282
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01051"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class I; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01051"
     gene            6336..6512
                     /locus_tag="KNP36_003455"
     CDS             6336..6512
                     /locus_tag="KNP36_003455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875284.1"
                     /translation="MFRDEMDKCTHMLTAYISSLYDYCDFIDTQLDDFILEYGENVVE
                     SCLHQVMVLVSKYN"
     gene            complement(6683..6922)
                     /locus_tag="KNP36_003456"
     CDS             complement(6683..6922)
                     /locus_tag="KNP36_003456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875285.1"
                     /translation="MKCSNCGSVNIEKGILTTGGIYAETIGLKYRGDGKLDKVINKTF
                     PVQSTIYSDLCLDCGEIVRTYIKDNTDRNWCKDKK"
     gene            complement(7037..>7829)
                     /locus_tag="KNP36_003457"
     CDS             complement(7037..>7829)
                     /locus_tag="KNP36_003457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010293327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0875286.1"
                     /translation="GRDSLMYYEEIGILRPVRDINGYRMYNISDIWKLNLIKEFRSLN
                     FPMKKIKEYLDDRSIESTKNILNEELDLIDKKIAEFISHKENIIKRLSSIESVIQNTK
                     IDEIEVVYIEKRKALELNADIKRDEDFDFLIQKLQKEYEDRFNILGNNNIGSAFSTEA
                     INKGIFNEFKSVFCFLESNEKVYNIVFDEGYYVTLNYTGSNSNNKMYMEKVFKFIEEN
                     NYKIIADPIEIYKIDIHETGIVEEFVTEIQVPITKYLYFNGLDGK"
BASE COUNT         2775 a         1141 c          848 g         3065 t
ORIGIN      
        1 attttgaata aactcgtaag gataaatttc ttgtaataag taccttaaag actttgaatt
       61 tataatactt gaaaagaaat catatccttt ttcagtcaaa ttatgtgctt catctactat
      121 tatattttct aaaggttttt catccttata cggccattta gctaatagtg aatgatttac
      181 tactgttata tgttcttctt ttaattcttc tattctgttt ttatataaac aatctttttt
      241 gcatttttta ggtctgcaca tatttgggtc acaacttaca tttcttaagt gagtacttat
      301 ttccttgaag ttgtcaaaca ctaaataatt tatttcttct atatctccat acttgccacc
      361 ttcaactaat ctcttcaaaa atattaaaga taaaatttct cctttagtag ggttttgaga
      421 ctcataatca tctatatatg cttccagtct atctatacaa atatagttat tttttccctt
      481 tatatatccg taacttactt ttccatttag acccaaagaa tctaacacat ttggaatatc
      541 tttatttatt aattgtatct gcaattcctt tgtgtcagta gaaattaata atcttttttt
      601 attaattcta gcctctaata ttgcaggcaa taaatatcct acacttttac ctataccagt
      661 tggtgcctct atacatgcaa ttttttcttc atcttcgcta tttctaaaca actctcttat
      721 tgttttagta agctcatatt gaccaggtct atattcatat gtaaatcctt ctttattctc
      781 ccaaatagtt ttgtatttta ataattcttc ataatttttt tcttcttcat ttaaaatttt
      841 taaggtttct ctttccttct tcttttcttc ttttgagtca aatatattat attctttttt
      901 tatatttata ttatttgata aatcataatt tgcctcttct aaaaatttgc tccattccca
      961 tgttggaaga ttaaattttt taagatatga atttatttta aaactcaatg gctccaaagt
     1021 agttttttca tagttattaa attttactaa aaggcaattt acaatattta ttatatcaat
     1081 agcatctgat aaagctctat tttccacttt agaattacaa tttgttaaag tattttttaa
     1141 gtattctaag ctataatctt tatgatatgg ttctaaaata actgctaatt caattaaatc
     1201 aataaattta ttttttaact ttggcatatg atactcaaaa aacttttttt tcagacttaa
     1261 atcatgacat ataatgaaac tatcttctac aaaatttaca agtctatctt ccaccagttc
     1321 tattttatta gctatttcta aatcattttt atctaaattt ttacatactg agaatacttc
     1381 tataggtacc tcaaatttgt tttttattaa tgattcatag gtatatattt tccagtcttt
     1441 aaccttgaca gctccaactt ctaaaatttc tgaatttaaa caatctaatc cactaacttc
     1501 tatatctaaa aaaacaacat cattcaatac acttattata ttatccattt ttatatccct
     1561 tcaagttaaa ccagcctaac ttatttacaa tcatttctct ttatatttta tcatttatat
     1621 acactttatt taagataatt aatatcaact ttatatctta cagtaaactt ctttcattta
     1681 ttatttgtat atgtgaatat ttttaactat aaatattcaa actatattat aagaaatata
     1741 ctttaaattt taaataagag gtgaaattgt gaaaaaagat agcctaaaaa aatacattat
     1801 gataggagca tttgctctaa cactttttgg aattgctagt ataaatttta aatcattaga
     1861 taaaacaaaa actcaaattt ctagtccaac actcgacaca catgaatatg attggtattt
     1921 taaccctagg gaagatggta aacagccatc acctataaaa gaagctgatt tttttaaaaa
     1981 atacggagct tattatgtag gaaatcccaa tgaaaaagtt atatatctat catttgatgc
     2041 tggatatgaa agtggaaaca ctccaaaatt attagatacg cttaaaaaac acaatgctaa
     2101 agctcaattt ttcgtagttg aaagttatat aaaaagcaat ccagagttaa taaagcgtat
     2161 ggaaaaagaa ggacatttag tttgtaatca ttcaaaaagc catccatcaa tggcaggtat
     2221 tacagatttt gaaaaattca aagaagaaat tacaagtgta gaaaaagcat acaaagatgt
     2281 tactggaaaa gaaatgccta agtattttag acctccaatg ggtaaattta gcgaacaatc
     2341 tttaaaatat acacaagatt taggatataa atcaatattt tggagttttg cttatgtaga
     2401 ttggtatgaa aagaaacaac ctactcatga atttgccaaa aacaaaattt attcaagaac
     2461 tcatcctggt gcaatagttt tactgcatcc aaattcatca acaaatactg agatattaga
     2521 tgaggttctt acacattggg aaaaagaagg ttataaactt aaaacacttg attatttaaa
     2581 taataaaaaa tagtatcata aatttaaaaa aactctatca tgaattatag taaaaatata
     2641 gttatttata aatactttaa ttctcgatag agttttttat tttttatagc tatttaaaaa
     2701 gaattgtcca ttcatttatc tctttgtatc ctatattatg atatatttta cctgctacat
     2761 cattattata aaaaagacat ggaacttttc cttctaacaa caattcttta ctcaaattgt
     2821 aaaccatata acttgcaagt ccttttcccc tatatctttt atctgtactt acagagacca
     2881 ccattgccaa aaaactagtt tccataccag ttgacacagt gctaatcata gtatcatcat
     2941 ttctaataaa atatgctctt acatttccct cttttaaatg aacttttctt tcttctatgt
     3001 aatttttact tactttatag tctgacctat ttaaaagttt tcctatttca tcaatatctt
     3061 tttcctgagc attttctatt ttatactcct tcatgttgga aaaatctatt tcttttattt
     3121 cttttaatac acaaaattta ttatctagtt tttcataaaa atctttgtat ttacttatta
     3181 gtctatctat tacacatttt tttccactta tgctttctac atctaaatct tttatatgat
     3241 tcttcatttc tcctatatta aaattatttt taaaactata aattataagt gttgacttat
     3301 tttttaatat tatagaggtt atatttccac cttctacctg agaccatata tcttgatatt
     3361 gagagctaaa tccataattc tcaacgtatc caattatgaa taaatttaaa ctttcttcat
     3421 gtgatacata ttgccaaaat tctttttcta aagtattatc tatttttaca atcaagcaga
     3481 tatcctcctt ctatgttaat aatgatatac cttataattt atagtatcat ttaaaatcat
     3541 tatattctac caaatattct aaatttttaa atatctatgc aatatgttcg tatttatttt
     3601 tatattctgt tactgcttca ctccaagctt cttctactga aatacctctc ttatttgcaa
     3661 ttttttgtgc taattctatt attttcatag cttttcttga tatattcata tatattcctc
     3721 ctctaaatta tcataagtta ttttaaagtt aaatttctat agtcatgtta tatatttatt
     3781 tacttatatc ttactaatta tttatgtact aaatatgaac tacaatagaa gaaatttaga
     3841 acttaataaa acataaaatt tatatacagt tcatatatat ttgtcatatc acaagacaag
     3901 tgatataatt tattatcatt ttactggggg tgatatgcta tgaaaataag agctgaatat
     3961 acatgtcctc ttgaaattgt acatgacata atcaaaggaa aatggaaaac tatccttata
     4021 tttgaattaa gacaatctaa taaaacattt tctgaattgc aacataatat ttatggaata
     4081 aatcaaaaaa tgttgattca acaattaaaa gagttacgtg attttgggat tattgataaa
     4141 ataagttctg ctggatatcc attacatgtt gaatattttc ttactaatcg tggtaaaaaa
     4201 atgttaaaag cagtggaaat aatgcaagaa ataggaatcg aatatatgct tgaacatggt
     4261 caacaagaaa ttctagataa taaaggaatt tgctacaata agtaatccta tacataccaa
     4321 aaagtaagta atttacattt tttacaatag tattataata aaaataaata ggaggtataa
     4381 tcatgtctat agctttaata ttgattgata ttcaaaatga ttattttaaa aatggaaaat
     4441 gtgaattatt tcaatcagaa gaaactgctg aaaatgctaa aaaaatacta ctgtttttta
     4501 gaaaaaacaa tttaccagtt attcatatac agcatatatc aacagataaa acagcttctt
     4561 tttttcttcc taatactcat ggttcagaaa taaataaaat tgtttttcca ctagataatg
     4621 aagaaattat aattaaacac acaccagata gtttctttga aacagatttg caaagtatcc
     4681 ttgagaaaaa aaatattact aatctagtaa tctgtggaat gatgagccat atgtgtattg
     4741 atacaagtgt aagaacagca aagaaacttc gatacgacat aactctaata agcgatgcat
     4801 gtacaacgaa gaatttatct tggaataata tagaaattaa tgcaaatact gtacatcaag
     4861 tattcatggc atcactacag aacagttttg cagatgtaaa aaacacagat aaatttttat
     4921 ctaactatta caaataaaaa catacactat gttaaaagag caagtttgat ttatttaagc
     4981 ttgctcttta atcatttaaa attagatgct ttctatcatt tttatataca taatatacgt
     5041 ttatacattt tatattcata tataactatt atataaattt taaactttac tatattcaca
     5101 taaaaaatgt agtattatag tatatataat attatataga agggggtgct agataaatga
     5161 accatcatat attgattcaa tttgaatata tagcaagaat cattactgct ggtttctgtg
     5221 gggctttaat tggatatgag agaaagaata gactaaaaga agctggaata cgcactcatt
     5281 ttatagtggc attagcttca gcacttataa tcattgtttc caagtatgga tttaatgata
     5341 tagtgggtac tccaggtatt ggtctagacc cagcccgcgt tgcagcacaa gttgtcagtg
     5401 gtataggttt tttaggtgct ggattaatat ttattagaaa tcaatcagta agtggtctta
     5461 ctacagctgc tggtatatgg gcaacagccg gtacaggtct tgccattggc tctggattat
     5521 acttagttgg tattgtttca agtatcatta ttgttattgt acagataaca cttcatagag
     5581 ataggaaatg gatgaaactc cctacagcag agcaagtttc tcttaaaatt tctaacagca
     5641 ctgattccat agaatatatt gaaggtaaat ttaaaaaatc taatattgaa attataaaca
     5701 tgaatattaa acgccttgat ggggattggt tagaagtagt tatatatact aagttaccta
     5761 aaggatataa aaaaacaaat ttattaaaat tatttagcga taatcctctt atagaaactt
     5821 tagaaatata atataaaaat tgaagcttaa aaataataat atatttaatc aaggtcaata
     5881 tataaataat taagggatga gtctatataa aattcatccc ttgttttttg ccattcatat
     5941 atattttttc aagatatttt tgtttatcta ttatctagcc aagtaaccct tgtgaactaa
     6001 actttttaat acaaaaactt caatacaaaa ctaaatataa tttttattaa acattctata
     6061 catatagttt gtttcttgag tgaaaaatag atttcatatt gttaagatat tgttaaatat
     6121 ttcaattttc tgacaagtat gttgaacaat aacttatcct agtgtattat tttagttgta
     6181 gaataaaact aaatcggcaa aactagagaa atttagtgac gcaaagctat agggactaac
     6241 gcttataaaa taaactatga gttatgtcag ccagttgcca aaaagatatt gttctttttg
     6301 ttttatgaaa gttttttagg gggatagtaa tatatatgtt tagagatgaa atggataaat
     6361 gtacacacat gttaactgct tatattagta gtttatatga ttattgtgat tttatagata
     6421 cacagctaga tgattttata ctagagtacg gagaaaatgt agtagaatct tgtttacatc
     6481 aagtgatggt attggtaagt aagtataatt aaatagaaat tgttttctag agaacccttt
     6541 ttagttttat ctacatttaa aaatgttatt atattaaaaa actaatcttc catatatgca
     6601 aagttttctt ccatataaca atttcttccc atttatactt tttcacttgt atctttaata
     6661 aaattcaact tcaaaaatta ttctatttct tatctttaca ccaattccta tcagtattat
     6721 cctttatata ggttctaact atttcgccac aatctaaaca taaatctgaa tatatagtag
     6781 attgtactgg aaaagtttta tttataactt tatctaattt tccatctcct ctatatttta
     6841 atccaatagt ttcagcatat atgccaccag ttgttaaaat tcccttttca atatttacac
     6901 ttccacaatt agaacatttc acatttataa ccccctaaac aattattttt tcatgctatc
     6961 ttataattta aaatataatt tgctaccgat tttataacac agtggcaaat cggtgccaaa
     7021 tcaacatttt ttcattctat ttaccatcta atccattgaa atatagatat ttagttatag
     7081 gaacttgaat ttctgttaca aactcctcta caattccagt ctcatgtata tctatcttat
     7141 agatttctat agggtcagca attatcttat aattattttc ttctataaat ttaaacacct
     7201 tctccatata catcttatta ttagaattac tcccagtata atttaaagtt acataatatc
     7261 cttcatcaaa aactatatta tatactttct cattactttc cagaaaacaa aatacagatt
     7321 taaactcatt aaatatgcct ttattaattg cttcagtaga aaaggcagaa ccaatattgt
     7381 tgtttccaag tatattaaat ctatcttcat attctttctg aagtttttga attaaaaaat
     7441 cgaagtcttc atccctcttt atatcagcat ttaattctaa agcttttctt ttttctatat
     7501 atacaacctc tatctcatct atttttgtat tttgaattac actttcaatt gaactcaatc
     7561 tttttataat attttcctta tggcttataa attcagctat ttttttatca attaaatcga
     7621 gttcttcatt taaaatattt ttcgtagact ctatacttct gtcatctagg tattctttta
     7681 ttttcttcat tggaaagttc aagcttctaa attcttttat taaatttaat ttccatatat
     7741 ctgatatatt atacattcta tatccattta tatctctaac tggtcttaga atgcctattt
     7801 cttcataata cattaatgaa tctctacct
//
LOCUS       DAEHWM010000138         7748 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.141, whole genome shotgun sequence.
ACCESSION   DAEHWM010000138 DAEHWM010000000
VERSION     DAEHWM010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7748)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7748)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7748
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.141"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..240
                     /locus_tag="KNP36_003458"
     CDS             <1..240
                     /locus_tag="KNP36_003458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HBF0875287.1"
                     /translation="RMNEHKLGINSKYTRAKGFEKLEVYFVTNTKSNAMKLEYYIKKL
                     TRNKKLSIIKNPSILINLIDNKEDYIIGKEIEQLT"
     regulatory      333..425
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            525..1319
                     /gene="thiD"
                     /locus_tag="KNP36_003459"
     CDS             525..1319
                     /gene="thiD"
                     /locus_tag="KNP36_003459"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HBF0875288.1"
                     /translation="MSNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAIT
                     AQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKIGMVSSPEIILEIVENLKKYNPK
                     YLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMK
                     RVGEEILQLGPKFVLMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSA
                     ITSYLALGYEITEAVNLSKIYITEAIKRSFDIGHGVGPVHHFYKFE"
     gene            1343..2131
                     /gene="thiM"
                     /locus_tag="KNP36_003460"
     CDS             1343..2131
                     /gene="thiM"
                     /locus_tag="KNP36_003460"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HBF0875289.1"
                     /translation="MYNLIKDVKKLNPLVIHYTNNVTINDCANVTLAVGASPLMSFSY
                     EEVEEMVSVANSVVINIGTMNSNMLDLFLLAGKAANKYNKPVVLDPVGVFASKARAEL
                     TSRLLNEVKFSVVKGNVSEIKFIGGFNVRGKGVDSFDEEEDSTEIIRKIAEKLECVVV
                     ATGKIDIITNGKGTYKINNGTDKLKGITGTGCMTASLIASFMAVTENILEAATMGVLT
                     MSLSGELANLNNPPIGTFKENLMNAIYQMDIDALSKNSNIEFLN"
     gene            2154..2786
                     /gene="thiE"
                     /locus_tag="KNP36_003461"
     CDS             2154..2786
                     /gene="thiE"
                     /locus_tag="KNP36_003461"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HBF0875290.1"
                     /translation="MIDKESLKKCLKLYLVTDSEMLKGRDFYKCLEDAISSGITTVQL
                     REKNASGREFLRKAMKLREITKRYGVKFIINDRVDIALICDADGVHVGQSDIDVREVR
                     KLIGNNKILGVSARTLEEAICAKNDGADYLGVGSIFTTSTKLDAKSASFETVKEIKEK
                     VDMPFVLIGGINLDNIDKLKCLESDGYAIISAILKAEDISKEVEKWTLKI"
     gene            2925..3227
                     /locus_tag="KNP36_003462"
     CDS             2925..3227
                     /locus_tag="KNP36_003462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436486.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HBF0875291.1"
                     /translation="MIRILLVCVGGMSSTLLVNKMEKDAKKRNIDCKIWAVGEGDIKS
                     ELDNFDILLLGPQLRFMLDDVKSIVGDRAPVSIIDMVNYGTCNGHAVLNSVLEILK"
     gene            complement(3293..4048)
                     /locus_tag="KNP36_003463"
     CDS             complement(3293..4048)
                     /locus_tag="KNP36_003463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875292.1"
                     /translation="MGMLNILWRSMKWRFKNPISFVVTILQPFLWLVLYSSIANQTMN
                     NININNYTAFILPGIIVLVVFSSCSSGGIINFIMKNSGSFYRVLIAPISRYSIVLGQL
                     LEAILVSFIEVTILCIVSIFFSVRIESGIGGILLMIVLIFMTAFFLSSLAYSISLLLP
                     NEIVYETIMTAIVLPIFFLSSALFPIESLSGGLKVAVMLNPFTHVINALRSLIFGETI
                     LIGDIMPVILLFLILCCSSFSLAMWRLKKEMVS"
     gene            complement(4036..4998)
                     /locus_tag="KNP36_003464"
     CDS             complement(4036..4998)
                     /locus_tag="KNP36_003464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875293.1"
                     /translation="MLAIEIDNLVKEYKNGVKALNGLSFNVNAGEIFSLLGPNGAGKS
                     SLINILTTFYKPTSGNVTMFGKDLVDNPSWIRTQIACVAQQISIDEHLSLMENMVFQS
                     KMYKVEPQIAKQRIDSLIDKFDLSSYLKYPTSSYSGGVKRRLDIAMNMVSSPKILFLD
                     EPTVGMDVDSRKSMWDMLLKIRDEYGTTIFLTTHYLEEAEQLSDNICIMKNGKDLAQG
                     TPSSLRSYIRQNILRITFHNTEDIKKYKDSIKSTGLVKFMSVRENSIFISVNDSRTAF
                     TLINKWLLEHDIEFDAIEIVEPSLEDVFLALTSSKKSLKEEWEC"
     gene            complement(5002..5460)
                     /locus_tag="KNP36_003465"
     CDS             complement(5002..5460)
                     /locus_tag="KNP36_003465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GyrI-like domain-containing protein"
                     /protein_id="HBF0875294.1"
                     /translation="MNCKIEIKNIESVTVATMRYNGPMTEATKYFPNVFKAIKGKSNG
                     APFFCYYDVDQKTGVAEMELCVPTAETPNRMGITTKEFPKTKALFFTHTGSYSNLPKT
                     YEMIFKYIHENNIKIQTPWREVFIKGPGMLIKGNPDNYITEIIFPLKEEE"
     gene            5816..6172
                     /locus_tag="KNP36_003466"
     CDS             5816..6172
                     /locus_tag="KNP36_003466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0875295.1"
                     /translation="MNFELDNTTPIYLQIVKYIKRQIVTGELKPGETIPSRREMALNL
                     KVNLNTVQRAYKEMGDMNIINTFKNYQSSVTVDENILKNLKLELINESLSVFIEDMKA
                     INVSKEEVLKIIEDKY"
     gene            6244..6960
                     /locus_tag="KNP36_003467"
     CDS             6244..6960
                     /locus_tag="KNP36_003467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905518.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875296.1"
                     /translation="MIEIKNVSKTYKRMQGLKIRKIEALKNVSFNIEKGKITALLGIN
                     GVGKSTMLKAIAGLINIDSGEIRIDGEKINEKVYNKLAFVPDVQSHFSNTTIKETFEF
                     MEIFYSKWNKEKSKEMMDIFKLDEDEIIDNLSKGNIARVKLILGFCQDPEYILLDEPF
                     TGIDLFKREEFIGVIAQYMEENQAIIITTHEIVEIESLVDEVVILDEGQIITSFNAEE
                     LREREGKSILDKMREVYKNE"
     gene            6953..>7748
                     /locus_tag="KNP36_003468"
     CDS             6953..>7748
                     /locus_tag="KNP36_003468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875297.1"
                     /translation="MNKLLYLINVDLRRSNKFYIAYISFFSLITLSLNLFEINKFKNS
                     KFIMNLAIEDFGGIFYGLGILSNLGFIQSILFFGILGLFIYYIFMWKREFFSNNQSIY
                     TLMMLPQNKFKICISKSIALITMIYGFLISQTATLFICKYIFNFIFRNMPIINMNFAK
                     DLYYLNLKSIPIDFISFMAIYVFLLLIAISIVNCCILFIFSYINKFYVILITLLIIAG
                     LYFSTIYINIITLFRKYYNLIGFQFNNLVAGLLSFLIIMFILNGISY"
BASE COUNT         3009 a          901 c         1258 g         2580 t
ORIGIN      
        1 agaatgaatg aacataaatt aggaattaat tcaaaataca caagagcaaa gggatttgaa
       61 aaactagaag tttattttgt gaccaacaca aaaagcaatg ctatgaagtt agaatactat
      121 ataaaaaaat taactagaaa taaaaaattg tctataataa aaaacccaag tatacttata
      181 aatttaattg ataataaaga agattatatt attggtaagg aaatagaaca attaacataa
      241 atatttatag taacattata atgggtgcat atggtgtaaa aacttgacaa taaatactat
      301 tgtaatataa tgaagttata aatatagtaa attaaaatag ctaggggagc caagagctga
      361 gaggtatacc gacccttaca cctgatctgg ataataccag cgtaggaaag cttagtaaaa
      421 attcaagtat gtattatttg tgatatatgc tatttctaag ctatacctat tgtaggtata
      481 gcttttttaa ttaagttatt taaattaaac tttaggaggc aacaatgagt aattataaaa
      541 taccaacact tacaatagcc ggctctgatt catctggagg agctgggatt caggctgatt
      601 tgaaaacgtt tagtgcaatt ggtacttatg gtatgagtgt aataacagct ataacagcac
      661 agaatactaa aggagttttt gctgtagagg atttaaataa gaaaataata aaaaaacaaa
      721 tagaggcagt ctttgaagat atacctccaa gagctgtaaa aataggaatg gtttcaagtc
      781 ctgagattat acttgaaata gttgagaatc taaagaaata caatccaaaa tatttggttg
      841 tggacccagt aatgatatct aaaagtggat attatctatt aaagccagag gcaaaagaaa
      901 acttaattaa gtatttgata ccacttgcat acataattac accaaatata ccagaggcag
      961 aagaaataac aggaataaaa atacataatg tagatgatat gaagagagta ggagaagaaa
     1021 tactacaact tggacctaaa tttgtactta tgaaaggagg tcatttagat ggagaagcag
     1081 tggatatttt agttggtaaa aatatattta aagtttataa aagtgaaaga attgataaaa
     1141 aaaatacaca tggaacaggg tgcacattat cttctgcaat aacatcttat ctagcattag
     1201 gatatgaaat aacagaagca gtaaatctaa gtaaaatcta tataacagaa gcaataaaaa
     1261 gaagttttga tataggtcat ggagtaggac cagtacatca tttttataaa tttgagtaat
     1321 aaaaaaatat tggaggtaga atatgtataa tttaattaaa gatgtaaaaa aattaaatcc
     1381 attggtaatt cattatacta ataatgtaac tataaatgat tgtgctaatg taactttagc
     1441 tgtaggagca agtcctctta tgagtttttc atatgaggaa gtagaagaaa tggtaagtgt
     1501 agcaaactct gtagtaataa atataggaac tatgaactca aatatgttgg atttattcct
     1561 attagctgga aaagcagcaa ataagtacaa taaacctgtt gttttggacc cagttggagt
     1621 atttgcaagc aaagcgagag cagaacttac aagtagactt ttaaatgaag tcaaatttag
     1681 tgttgttaaa gggaatgtat cagaaataaa gtttataggt ggctttaatg taaggggtaa
     1741 aggtgtagat tcatttgatg aagaagaaga ttctactgag ataataagaa agattgctga
     1801 aaagcttgaa tgtgtagttg tagcaactgg aaaaatagat ataataacta atggtaaagg
     1861 tacatataaa ataaacaatg gaactgataa attaaaagga attacaggaa ctggatgtat
     1921 gactgctagc ttgattgcaa gttttatggc tgttactgag aatatattag aagcagcaac
     1981 aatgggtgtt cttacaatgt ctttaagtgg ggaattagct aatttaaata atccaccaat
     2041 aggtacattt aaagaaaatc ttatgaatgc tatttatcaa atggatatag atgctttaag
     2101 taaaaattct aatattgaat ttttaaatta ataaagagta agggagactt aaaatgattg
     2161 ataaagaatc tttaaaaaaa tgtttaaagt tgtatttagt aactgactct gaaatgctta
     2221 aaggtagaga cttttataaa tgtcttgaag atgcaatatc ttctggaata acaactgtac
     2281 aacttagaga aaaaaatgct tctggaagag agtttttaag aaaagctatg aaacttagag
     2341 aaataactaa aagatatggt gttaagttta taataaatga tagagtggat atagcactta
     2401 tttgtgatgc agatggagta catgtaggac agagtgacat tgatgttaga gaggttagaa
     2461 agcttatagg aaacaataaa attctaggag tatcagcaag aactttagaa gaagctattt
     2521 gtgcaaaaaa tgatggcgca gactatttag gtgtagggtc tatattcaca acatctacta
     2581 aattagatgc aaaatcagct tcgtttgaaa ctgttaaaga aattaaagaa aaagtagaca
     2641 tgccatttgt actaattgga ggtataaatt tagacaatat agataaactt aaatgtttag
     2701 aaagtgacgg gtatgctata atatcagcta tattaaaagc tgaagatatc tctaaagaag
     2761 tggaaaagtg gacattaaaa atataaaatt ggctctggta gtgaaaaaaa tggaaaaatt
     2821 tgatataatc taagagtaaa atttaagcaa ttataaatga taaacttttc tacatatact
     2881 ttttaatcaa gatatatgta gatttggtta aaaaggagct ataaatgatt aggatattgt
     2941 tagtgtgtgt tggaggcatg tcttctaccc tattggtaaa taaaatggag aaggatgcaa
     3001 aaaaaagaaa tatagactgt aaaatatggg cagttggaga aggagatata aaatcggagc
     3061 ttgataactt tgatatttta cttcttggac cacaacttag atttatgctt gatgacgtaa
     3121 agtctatagt tggagataga gctccagtat ctataataga tatggtaaac tatggcactt
     3181 gtaatggtca tgctgtgtta aattcggttt tagaaatatt aaaataaata ataaaagtgg
     3241 attctatata atagagtcca tttttattat ttgttattaa taggcttaaa acttagctta
     3301 ccatttcttt ttttaatctc cacatagcaa gtgaaaaact tgaacagcac aatattaaaa
     3361 atagtaggat aacaggcatt atatctccaa taagaatagt ctcaccaaat attaagctac
     3421 gtaaagcgtt aataacatgg gtaaatggat tgagcatcac tgctactttt aatcctccag
     3481 ataaactttc tatagggaaa agagctgaac ttaaaaagaa aataggaagt acaattgcag
     3541 tcataattgt ttcataaact atttcatttg gcaataataa acttatagaa taagctagac
     3601 ttgataaaaa gaaggctgtc ataaatatca gtactatcat aagtaggatt ccaccaatgc
     3661 cagattctat ccttactgag aagaatatac ttactataca caaaatagtt acttctatga
     3721 aagaaactaa gatagcttct aataattgac caaggacgat tgaatacctg ctgataggtg
     3781 caattaagac tctatagaaa cttccactgt tcttcattat aaagtttata ataccaccac
     3841 tactacaaga agaaaacaca accagtacaa tgatacctgg tagtataaaa gcagtataat
     3901 tattgatatt tatattattc atagtttggt ttgcaataga actataaagc acaagccaaa
     3961 gaaaaggttg taatatagta actacaaatg agattggatt tttaaaacgc cacttcatac
     4021 tacgccataa gatatttaac attcccattc ctcctttaag ctttttttag aacttgtaag
     4081 tgctaaaaat acatcttcga gacttggctc tacaatttct attgcatcaa attctatatc
     4141 atgttctaaa agccatttat ttattaaagt aaaagcagtt ctactatcgt ttacacttat
     4201 aaaaattgaa ttttctcgta cgctcataaa ctttactaaa ccagtacttt taattgaatc
     4261 tttatatttt tttatatctt cagtattatg aaaagttata cgtagtatat tttgtctaat
     4321 gtaactacgt aaacttgatg gtgttccttg tgctaaatcc tttccattct tcataataca
     4381 aatattatca ctcaattgtt cagcttcttc aagataatga gtagttagaa atatagttgt
     4441 gccatactca tctctaattt ttaataacat atcccacata gattttcttg aatcgacatc
     4501 cataccaaca gttggttcat ctaaaaatag gattttagga gatgatacca tattcatagc
     4561 tatgtccaat ctacgtttta caccccctga atatgatgaa gtaggatatt ttaagtaact
     4621 agataagtca aacttatcaa ttaaagagtc tattctttgt tttgcaatct gtggttctac
     4681 tttatacatt ttactttgaa ataccatatt ttccataagg gataaatgtt catcaataga
     4741 gatttgctgt gctacacaag caatttgagt acgtatccaa gaaggattat ctactaaatc
     4801 ttttccaaac attgttacat ttccagatgt aggtttgtaa aaggtagtca aaatatttat
     4861 aagagaagat ttaccagcac cattaggacc aagtaaagaa aaaatttctc cagcatttac
     4921 attaaagctt agaccattta aagctttcac accattttta tattctttta ctaaattgtc
     4981 tatttcaatc gctaacatat attattcctc ctctttaagt ggaaatatta tctctgtaat
     5041 atagttatct gggtttcctt ttatcaacat acctggtcct ttaataaata cttctctcca
     5101 aggagtttgt atttttatat tattttcatg aatatattta aatatcattt catacgtttt
     5161 tggcaaatta ctataagagc ctgtgtgagt aaaaaataaa gcttttgttt taggaaattc
     5221 ttttgtagtt atacccatac gatttggagt ttcagcagtt ggaacacata attccatttc
     5281 tgcaacacca gttttttggt caacatcata gtagcaaaag aatggtgcac cgttagactt
     5341 tccttttata gctttaaata catttggaaa atactttgtt gcctcagtca taggtccatt
     5401 ataacgcatg gtagccactg tgactgattc gatatttttg atttcaattt tgcaattcat
     5461 ttgtttacct cctaatgtgt gttcatattc ttactagatt tttaagcatt aatacatata
     5521 agattttgat tagttgaaaa catataatct tatctcgttt gcttgttttc aagtctaaca
     5581 taacataaaa tatatatcct ctcatttgat gctccatttt gtaaagttat tatttaagct
     5641 ttactttaga ttttttagca aattaaaata aagcaattta taaaataagt atttacaaat
     5701 taagtgtatt aatcgtataa tacacttaat aggatactag ataaagtctg aaataaaggc
     5761 gtattttttt aaagtaagtg tactatcgta ttaatacact agaataggag gaatcatgaa
     5821 ttttgaatta gataatacaa ctcccattta tttgcaaata gtaaagtata taaagagaca
     5881 aatagtaaca ggagagttga aaccaggaga gacaatacca tcaagaagag aaatggcact
     5941 taatctaaaa gtaaacttaa atacagttca aagagcatat aaggagatgg gtgatatgaa
     6001 tataataaat acttttaaaa attatcaaag cagtgtaaca gttgatgaaa atatattaaa
     6061 aaatttaaaa ttagagctta taaatgaatc actatctgtt tttatagaag atatgaaagc
     6121 aataaatgtt agcaaagaag aagttttaaa aataatagaa gataagtatt agttttttaa
     6181 caaatagaaa acttagttta gaaagtttat ttataagcat attggatgtg gaggatagta
     6241 aatatgatag aaataaagaa tgtcagcaaa acatataaaa ggatgcaagg gcttaaaata
     6301 agaaagatag aagctttaaa aaatgtaagt tttaatatag aaaagggaaa aataactgca
     6361 ttacttggta taaatggtgt tggtaaatca actatgttaa aagcaatagc aggacttata
     6421 aacattgata gtggagaaat tcgtatagat ggagaaaaaa taaatgaaaa ggtatacaat
     6481 aaattggctt ttgttccaga tgtacaatct cactttagca atacaacaat aaaagaaaca
     6541 tttgaattta tggaaatttt ttattcaaag tggaataaag aaaaatcaaa agaaatgatg
     6601 gacatattta aattggatga agatgaaata attgataact tgtcaaaagg aaacattgca
     6661 agagtaaaat taatacttgg attttgccaa gacccagagt acatacttct tgatgaacca
     6721 tttacaggaa ttgatttgtt taagagggaa gagtttatag gagtaatagc gcaatatatg
     6781 gaggaaaatc aagccattat tataactact catgagatag tagagataga aagtttagtt
     6841 gatgaggttg taattcttga tgaagggcag attataactt catttaatgc agaagaatta
     6901 agagaaagag aaggtaaatc tatattagat aagatgaggg aggtatataa gaatgaataa
     6961 acttctatat ctaataaatg tagatttgag aagaagcaat aagttttata tagcttatat
     7021 atcatttttt tcattaatta cacttagttt aaatttattc gaaattaata aatttaaaaa
     7081 ttctaaattt attatgaact tagcaataga agattttgga ggtatatttt atggactagg
     7141 gatacttagt aatcttggtt ttatccaaag tatattgttc tttgggatat tgggactttt
     7201 tatatactat atttttatgt ggaaaagaga gttcttttca aataatcaaa gtatttatac
     7261 acttatgatg ttacctcaaa ataagtttaa gatttgtata tctaaatcaa tagccttgat
     7321 aacaatgata tatggttttt tgataagtca gacagcaaca ttatttatat gtaaatatat
     7381 atttaatttc atttttagaa atatgcctat aatcaatatg aactttgcca aagatttata
     7441 ttatttaaac ttgaagagta taccaattga ttttatctct tttatggcta tttatgtatt
     7501 tttactactt atagctattt ctattgtaaa ttgctgtata ttatttatct tttcctatat
     7561 aaataaattt tatgtaattt taatcacttt gctgattata gcaggcttat atttttcaac
     7621 aatatatata aatataatca ctttatttag aaaatattat aatcttatag gatttcaatt
     7681 taacaattta gtagcagggt tattaagttt tttaattata atgtttattc taaatggaat
     7741 atcttatt
//
LOCUS       DAEHWM010000139         7715 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.142, whole genome shotgun sequence.
ACCESSION   DAEHWM010000139 DAEHWM010000000
VERSION     DAEHWM010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7715)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7715)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7715
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.142"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            322..1623
                     /locus_tag="KNP36_003469"
     CDS             322..1623
                     /locus_tag="KNP36_003469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HBF0875298.1"
                     /translation="MGKSKDVEIEKSILGTILLDNKLSYKLDELNENMFMNDICLEIF
                     KIMKELKKENIVIDVATVKSKIDRKSLAIKTSDVTNLITWGQNFGLDGHIKILKENLA
                     RRSINQNCQNLLHSLNLGENIDTCIYKFESNIKEILDKDTYENDDVNSIAGKVLDFLE
                     NKKDIGFKFGIKLLDTTIGGLFKGELTTIAAKSGVGKTALALQIMLNSFKQGKKTLFI
                     SREMTSEQVFMRNICRVTGVSTRNMKSKEIDENDWKLIVNAIGDLSENNLIYINDKID
                     TISAIRKRIRQVKPDLLIVDYVQLLTSQKSMDKREREVATFSRELKNMTLDFNIPVIQ
                     LSQLNDEMKDSRPYGDRPMRDSKAIYHDSNNVVYIHQLKGSDYEEAVRDIGESEEAVR
                     ASEYRGIKMVDLIVAKCRDGQTRHKHFCYFGDKLHFQELNY"
     gene            1699..1974
                     /locus_tag="KNP36_003470"
     CDS             1699..1974
                     /locus_tag="KNP36_003470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBF0875299.1"
                     /translation="MLELRKIIELLEEHKIEVSIPKELHKYSLLEYLELCQQSGGTYF
                     YIKTLEGALKEARNELMIKLFNGKNYMELARMFEMSVINVRHIVRKK"
     gene            3309..3539
                     /locus_tag="KNP36_003471"
     CDS             3309..3539
                     /locus_tag="KNP36_003471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0875300.1"
                     /translation="MSNKKKKYANILANECVACGSCIKACPRSAISVPCGISAKINRD
                     LCVGCGICEKICPASVIEIITILKEEEGKCHE"
     gene            3532..4113
                     /locus_tag="KNP36_003472"
     CDS             3532..4113
                     /locus_tag="KNP36_003472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S binding protein"
                     /protein_id="HBF0875301.1"
                     /translation="MNNKKHWYDYLWIFSSIYLILGFVNIIFAWIGLICFFVPLAISI
                     VKGNKAYCNKYCGRGQLFNLLGNKLKLSRNRDIPKFIRSKWFRYGFLTFFMVMFANML
                     FSTYLVFEGSRNFKEVVTLLWTIKMPWQWAYHGTLVSPWVVQFAFGFYSVMLTSTVLG
                     LITMILFKPRSWCVYCPMGTMTQMICKAKSKSV"
     gene            complement(4692..5369)
                     /locus_tag="KNP36_003473"
     CDS             complement(4692..5369)
                     /locus_tag="KNP36_003473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBF0875302.1"
                     /translation="MISQNEIDILTHSLPFWDKLTDLQKELLISSANTSHYKKGNPVH
                     CGDSDCIGILIIKSGTVRTYILSDEGREVTLFRLDDGDVCILSASCILKTITFDVYVD
                     AETDCDIIQISSSVFAKLSTENIHAELFSYKLATERFSDVMWAMQQILFMSFDKRLAS
                     FLIDEIAKNGSSTINMTHEQIAKYMGSAREVVSRMLKYFAREGIVSLSRGGIKVLDKD
                     KLRSLTL"
     gene            complement(5558..6922)
                     /locus_tag="KNP36_003474"
     CDS             complement(5558..6922)
                     /locus_tag="KNP36_003474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0875303.1"
                     /translation="MKESNKRIELLGSAPISKALLSMGLPTMIGMMITALYNLVDAYF
                     VGGLGTSQMGAISVAFPLGQLVVGLGLLFGNGAASYVARLLGHGDNEKAGKVVSTSIY
                     SSIIVGTLVIIVIMIFLNPILKLLGATKSIMPYAISYASIYVVSSIFNIFNVTMTNIV
                     TSEGAAKTTMCAMLLGALLNMILDPIFIYTFGLGVRGASIATAISQIASTLVYVGYIL
                     SKKSIFSFRINECCFSKEIFSEILKIGIPTLIFQLLTSLAITLTNMEATKYGDSVIAG
                     MGAVTRITSLGSLVVFGFIKGFQPIAGYNFGSKNYDRLHIAIKTSILWTTVFCVVLGL
                     ILILFPKSIISQFTSGDILLIENGSKALRANGFSFMLFGFYTVYSTLFLALGKAKEGG
                     FLGMCRQGVCFIPIILIIPVFYGLNGILYAQPIADLMAAIIAGFMSIRLHKELNLLKI
                     NGMH"
     gene            7050..7571
                     /locus_tag="KNP36_003475"
     CDS             7050..7571
                     /locus_tag="KNP36_003475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HBF0875304.1"
                     /translation="MATIDLIVLGIVKQQPKSAYDIQKAVEYRNISRWVKISTPSIYK
                     KVIQLEQKGYIESKTVKNGKMPEKAVYSLTELGETHFLDLMFDTSSKPINILLDFNAV
                     IVNLNSLTPEKQKLCLNNIEENVQELKKTIEENISIKTEVPDTAKAVLEQQLVLAQAL
                     ETWINSLKDNMGN"
BASE COUNT         3015 a          880 c         1328 g         2492 t
ORIGIN      
        1 gagtaatgaa ttatattgaa cgatatatca ataattggca gtaagttata tcaaataaga
       61 tattactatc gagtaatgaa ttatattgaa caatatatta ataattggca gtaagttata
      121 tcaaataaga tattgctatt atgtagtaaa ttatataaaa caatgtatca gaataaatag
      181 tatattaata atttgtagta tatcatgacg aataatacag tcataacaaa tagtgagtca
      241 taacaaataa tgtatttata attgataatg tatttaaaaa tcaaaatata aaaacttata
      301 aggaaagaga gattaattta tatgggtaaa tcaaaagatg ttgaaataga gaagtctatt
      361 ttaggcacaa ttcttttaga caataaatta agctataagc tagatgaatt aaatgaaaac
      421 atgtttatga atgatatatg tcttgagata tttaaaatta tgaaagaact taaaaaagaa
      481 aacatagtga ttgatgtggc cactgtgaaa tcaaagatag atagaaaatc tctagcaata
      541 aaaacaagtg atgtgactaa tctaattact tggggtcaga attttggtct tgatggtcat
      601 attaaaattt taaaagaaaa tttagctaga agaagcataa atcaaaactg ccaaaacctt
      661 ttacacagcc taaaccttgg agaaaatatc gatacttgta tttacaaatt tgaaagtaat
      721 ataaaggaga ttttggacaa ggatacttat gaaaatgatg atgtaaatag tatagcaggg
      781 aaggtgcttg attttttaga aaacaaaaaa gatattggat ttaaatttgg tataaaatta
      841 cttgatacca ctataggagg tctttttaaa ggagagctaa ccacaatagc agctaaatcg
      901 ggggttggga agactgcttt ggcacttcaa ataatgttaa attcatttaa gcaaggtaaa
      961 aaaactttat ttataagtag agaaatgacc agtgagcaag tatttatgag aaatatatgc
     1021 agagtaactg gtgtaagtac aaggaatatg aaatctaaag aaatagatga aaatgattgg
     1081 aaacttattg taaatgcgat aggtgattta agcgaaaata acttaattta tatcaatgat
     1141 aagatagata caattagtgc aattagaaag aggataaggc aggtaaagcc agatttatta
     1201 atagtggatt atgtgcaact ccttacatct cagaaaagca tggataagag agaaagggag
     1261 gtagctactt tttcgagaga acttaaaaat atgactttag attttaatat acctgtaatc
     1321 caattaagtc agttaaatga tgaaatgaaa gattcaagac cttatggaga tagacctatg
     1381 agggatagca aagccatcta ccacgatagc aacaatgtgg tttatataca tcaattaaag
     1441 gggagtgatt atgaagaagc agtgagagat attggagaaa gtgaggaggc agttagagca
     1501 tcagaataca ggggaattaa gatggttgat ttaatagttg cgaagtgtag agatggacag
     1561 actaggcata agcatttttg ttactttggg gataagttac attttcaaga actaaattat
     1621 taggtcaata aagtagtaat aacaagctta ttaaaagtcg ggaaatagca aatagattat
     1681 aaaatatgag gtgaaaatat gttggaatta agaaaaatta tagaattact tgaagaacac
     1741 aagatagaag taagtattcc aaaggagtta cataagtata gtttattgga ataccttgaa
     1801 ttgtgtcaac aaagtggggg aacatatttt tatattaaaa cactggaagg ggctttaaaa
     1861 gaggctagaa atgagcttat gattaaattg tttaatggga aaaattatat ggaattagcg
     1921 aggatgtttg aaatgagtgt tattaatgtc aggcatattg ttagaaaaaa atagatattt
     1981 ttggagaata caagtgtgat atacttctga aatagaagtt attataagag gagtataagt
     2041 gtgattaaca acatgatttt gtgaataaaa ttgaggatat atatgagtta aatgtgtgat
     2101 taataaggta agattgtgta taagattatg agtatttaaa aggaggggct ataattaata
     2161 gtgtagagtt gtgtgtttgc ttaagattat ataataattt aatagattaa actatactaa
     2221 taaggtaaaa tcgtgtgttt agttaaagct tattataaaa tcttgatatg tgattaatga
     2281 tgcaatatgt gaataaagtt aagattataa tagatttaac ctgtggctaa tagaataaaa
     2341 ttgtgaataa agttaagatt ataataggtt taaattgtga ctaatagagt aagagtgtaa
     2401 atagagataa acttcaatat gagcttaacc tatgattaat agagtaagaa tgtaaataga
     2461 gataaacttc aatatgagtt taacttgtgg ctaatagagt aagagtgtaa atagagataa
     2521 acttcaatat gggtttaact tgtggttaat agagtaaggt gtaactaaag ataaacttca
     2581 atatgagctt aacctatgat taatagagta agaatgtaaa tagagataaa cttcaatatg
     2641 agtttaactt gtggctaata gagtaagagt gtaactaaag ataaacttca atatgggttt
     2701 aacttgtggt taatagagta agaatgtaaa tagagataaa cttcaatatg agcttaactt
     2761 gtgattaata gagtaagagt gtaaatagag ataaacttca atatgggatt aacttgtgat
     2821 taatagagta agagtgtaac taaagataaa cttcaatatg agcttaacct atgattaata
     2881 gagtaagaat gtaaatagag ataaacttca atatgggttt aacctgtggt taatagagta
     2941 gggtgtaact aaagataaac ttcaatatga gtttaacttg tggctaatag aataagattg
     3001 tgaataaagt tatagtttta gatgggtatt aacctgttac taatagaata tgattaggtg
     3061 taaaattata gagctgcata agaaaatatt atagatatat taaatattag ataataaata
     3121 tttatataga tacacaaaag aaaaggcgat atgaagctaa acttaatgac ttcatatcgt
     3181 tttttatttg aaactccttt gtatttagag tgtgattttt aatattgagg ttttatgtga
     3241 ttaagtcaca gataaaaagt aagtatcttg atataattct tatagattaa taatataggg
     3301 aggttattat gtctaataaa aaaaagaagt atgcaaatat tttagcaaat gagtgcgttg
     3361 cttgtggtag ctgtataaaa gcatgtccaa gaagtgctat ctcagttcca tgtggcatta
     3421 gtgcaaaaat taatagagat ttatgtgttg gatgtgggat ttgtgaaaag atatgtccag
     3481 catctgtaat tgagattata acaatattaa aagaggaaga aggtaagtgt catgaataat
     3541 aaaaaacatt ggtatgacta tttatggatt ttttcttcaa tatatttgat attgggattt
     3601 gtaaatatta ttttcgcttg gattgggcta atttgtttct ttgttccact agctatttct
     3661 attgttaagg gaaataaagc ttactgtaat aagtattgtg gaagagggca actgtttaat
     3721 ttgcttggaa ataaattgaa gctgtcaaga aatagagata ttcctaaatt tattagaagt
     3781 aagtggttta gatatgggtt tttgacattt tttatggtaa tgtttgccaa tatgcttttt
     3841 tcaacttatt tagtgtttga aggaagtaga aattttaaag aagtagtgac tttgttgtgg
     3901 actataaaaa tgccttggca atgggcgtat catggaactt tagtttcacc ttgggtggta
     3961 cagtttgcat ttggttttta tagtgttatg cttacatcaa ctgttcttgg tttgattact
     4021 atgatattgt ttaaacctcg ttcatggtgt gtttattgcc ctatgggtac tatgactcag
     4081 atgatatgta aggcaaagag taagtctgta tagaaaggcc ttatgtgata tttacagttt
     4141 tgttcaagta gagatgagta gtaggtttga atatatatga caaatatatg agtatagggg
     4201 catagattta gtttgtgtaa ggtaaactga tttatgcttc ttttttatgt cttagattat
     4261 tggctaagtg gaaacaatga atttagatat taagaattat tcagttattt gaagaaaata
     4321 gaataataat taacattata ttaatggata ttcattacat ataagccagt taatagcaag
     4381 atttatttaa tatgatatag gtcaagtatt taaactaaat aaggtcatga caattaatat
     4441 aagtatagat ataaaaagat tagaagttat aacttataaa aggtattcta tataaatagt
     4501 atggggaaaa tagtcaaatt aacttattag aaacaaaaaa tatacataaa aaataaatgt
     4561 aaatatcaaa taagatacta tatcaaaata gatataagta tcttttttat tattgaaatt
     4621 atgaaaatat atttgatttt acacaaaaaa gagtgcctca tgaactaaaa agttcatttt
     4681 gagacacact tttacagtgt caaagaacga agtttatcct tatccaatac ctttatacca
     4741 ccacgagata aagacacaat accttctcta gcaaaatatt tcaacattct cgatacaact
     4801 tctctggcac tacccatata cttagcaatt tgctcatgag tcatatttat agtgctactg
     4861 ccatttttag ctatctcatc aattaaaaaa gatgccaaac gcttatcaaa actcataaaa
     4921 agaatttgtt gcatagccca cataacatca gaaaaacgtt cagtagctaa tttatatgaa
     4981 aataactctg catgaatatt ttctgtagat aattttgcaa aaacagagga actaatctgt
     5041 ataatatcgc agtccgtttc agcatctaca tagacatcaa aagttattgt ttttagaata
     5101 caggaagctg ataaaataca tacatctcca tcatcaagtc ggaacagtgt aacctctcga
     5161 ccttcatctg aaagtatgta tgtacgcact gttccagatt ttataatcaa aataccaata
     5221 cagtcactat caccacaatg tactggattc ccttttttgt aatgcgaggt atttgctgaa
     5281 gaaattaata attctttttg taagtcagta agtttatccc aaaaaggcaa gctatgtgta
     5341 agtatatcaa tttcattttg tgaaatcata caatatctcc tttcttaaat tgttataatc
     5401 ccatgataca agtgaataga taaattgaca agtagtttgt taagaggatt atttagtcag
     5461 atagtaatag tatgatttat gtagaaaaaa tatgataata tatattcttg ctattaatga
     5521 gaaagtaata tgttttgatg atagtaggtt tgtataacta atgcataccg tttattttta
     5581 aaagattaag ttccttatgt aaccttatag acataaaacc agcaattata gcagccatca
     5641 aatcagctat tggttgtgca tataagatac catttaaccc atagaataca ggaataatca
     5701 aaattatagg gataaaacag acaccttgtc tacacatacc taaaaatcca ccttcctttg
     5761 cttttcctag tgcgaggaat aatgtagaat acactgtata gaatccaaat agcataaatg
     5821 aaaacccatt tgccctaaga gctttactac cattttctat taataaaatg tcaccacttg
     5881 taaattgtga aattatagat tttgggaaga gtatcaatat aagaccaagc actacacaaa
     5941 atactgtagt ccataatatg gaagttttta ttgctatatg taatctatcg tagttctttg
     6001 aaccaaaatt ataaccagca attggttgga aaccttttat aaaaccaaat acaacaagac
     6061 tacctaaaga cgttattcgt gttacagcac ccattccagc tatcacagaa tcaccatact
     6121 ttgtagcctc catattagtt aatgtaatag caagactagt caataattga aatattaagg
     6181 taggtatgcc aatttttagg atttctgaaa aaatttcttt tgaaaaacag cattcgttaa
     6241 ttctaaaact aaatatactt ttcttgctta aaatatatcc tacataaaca agtgttgaag
     6301 caatctgtga gatagctgtt gcaatagaag caccccttac ccccagacca aaagtataaa
     6361 tgaatatcgg gtctaaaatc atattaagca aagcacctaa taacatagca cacatagttg
     6421 ttttagcagc tccttcactt gtgacaatat tagtcatagt gacattgaat atattaaaaa
     6481 tagatgacac gacataaatg ctagcataag atattgcata aggcataata ctttttgtag
     6541 ctcctaacaa ttttaaaatt ggattgagaa aaatcataat cacaataata actaatgtac
     6601 ccactataat actactgtaa atagatgtac ttaccacttt tcctgctttt tcattatcac
     6661 catggcctaa aagtctggca acatatgaag cagctccatt tccaaacaat aatcctaatc
     6721 ccacaacaag ctgacctaat ggaaatgcaa cggatatagc tcccatttga cttgttccaa
     6781 gtccacccac aaagtatgca tcaaccaaat tgtataatgc agttatcatc atacctatca
     6841 tggtaggtaa tcccatagat aacaatgctt ttgagattgg ggcagaccct aataattcaa
     6901 ttcttttgtt actttctttc atacttaaca ctcctcttct attgacatta agtctaaatt
     6961 ataatactat aaattatagt aagtatggaa aatagtacta taatttatag tatttgtcaa
     7021 tagtaagaaa actaaaggag atgattttta tggctacaat agatttaatt gtattgggaa
     7081 tagtaaagca acaacccaag agtgcttatg atattcaaaa ggcagtggaa tacaggaata
     7141 tatcacgttg ggttaaaata agtacaccat caatttataa aaaagtaatt caattagaac
     7201 aaaagggata tattgaaagt aaaactgtga agaatggaaa aatgccagaa aaagcagttt
     7261 attcattaac tgaattaggt gagacacatt ttttagattt aatgtttgat acatctagca
     7321 aaccaataaa tattctttta gattttaatg ctgttatagt aaatttaaat agccttacac
     7381 cagaaaaaca gaaattatgt ctcaataata ttgaagagaa tgttcaagag ttaaagaaaa
     7441 ctattgagga aaatataagt ataaagacag aagtaccaga cacagcaaaa gcagtgttgg
     7501 agcaacagtt ggtgctagca caagcattgg aaacctggat aaattcttta aaagataata
     7561 tgggaaatta gaattagaga agctaactta ataatcatta aacaaaaacc agcatattta
     7621 ataatgagat attagaaaaa ataaaacaaa tgatataaac tgaaaagtat atttaaaata
     7681 aagctcactt aattgaggga gaatgttaaa ctttt
//
LOCUS       DAEHWM010000140         7690 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.143, whole genome shotgun sequence.
ACCESSION   DAEHWM010000140 DAEHWM010000000
VERSION     DAEHWM010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7690)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7690)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7690
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.143"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            160..1434
                     /locus_tag="KNP36_003476"
     CDS             160..1434
                     /locus_tag="KNP36_003476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBF0875305.1"
                     /translation="MITISHITAKNMYKSLEERINKFPQGAPPSDTLYKILNVLYTEQ
                     EAKLVAQLPIKPFRVKTAAKIWSVSESEAYRVLDKLASKALILDIEDNKGKKYIMPPP
                     MAGFFEFAMMRTRHDIDQKLLAELYYQYMNVEEDFIKDLFYSTETKLGRVYVQEEVLT
                     NDNEVSILDYERATHIIDESTHIGISMCYCRHRMQHVGKACDAPMDICMTFDNVANSL
                     INNKFARRVDKIECKELLHQAYEHNLVQCGENVRKGVTFICNCCGCCCEAMVAAKRFG
                     NLHPVQTTSFIPNINHENCVKCGKCITACPIDAISKVKEDGKEYIKIDEDRCLGCGVC
                     VRNCHKNSIMLLKRDEKIITPANSVHRAVLMAIEKGQLQNLIFDNNALASHRAMGAIL
                     SAILKLEPAKKILASKQLKSVYLDKLLSMNDK"
     gene            complement(1595..4636)
                     /locus_tag="KNP36_003477"
     CDS             complement(1595..4636)
                     /locus_tag="KNP36_003477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp20"
                     /protein_id="HBF0875306.1"
                     /translation="MFKQRLSKLLSSTLVLSMLFTAAPNITFADNTKDNSEKYQSSDI
                     ELHDYSKNAESYTKTKALAKEKIQTLLSKYGAVSAQYALIDNGKIEISGNGGVYSKQD
                     NKNLNKDNMYSIASISKMFTTTAVMKLVDDGKLNLDTPVVKYIPEFKMADDRYKEITP
                     RMLLNHSSGLMGSSFKNTILLADNDSYGHDNFLKELQKQRLKAKPGAFSVYCNDGFTL
                     AEILVERVSGMSFTNFLDKYINNPLNLQNTKTTENSFDSSKLAKAYVPYWEDAVPQDN
                     LNAIGAGGLYSSAENLCTFAQTFMKNSNGILSPASVKAMENKEYLNGLWPEGEDSILG
                     YGLGWDCVNTYPFNQYNLKALTKGGDSLLFHSNLIVLPDENMAVAVLSSGGSSQLNEI
                     IGQEILLSALKEKGKIKEIKPDKTFSKPQQVKMPSSLKENSGLYASSNMIKVDVNDNG
                     TLTVSSPYIENGPEDKYVYIGQDRFVSEKGNSCLKFVKEKNNITYLNMSSYDDVPGLG
                     QTASLYYVAQKIDDNNISNSVKEAWKKRNGKDYYLVDEKYTSQSYMFGSVKATLALSD
                     ETPGYIVNTKIMDENNSNAFIEIPGVIGRDLSDIKLHKENGTEYLSFGTLTYVSEDSI
                     TNLPAEKSFTCELESNGYAKWYKIGDDIANKKIEVNLPQNSAFAVYDDKGVPVNYSLV
                     TKNNRVRLPKGGVIVFLGSPNARFEVTYQDEVNASALTGTDRYETSIKISQAGWENAE
                     NAVLINDSAIADALAATPFAYKKNAPILLTGSSQINEKTLAELKRLKVKNVYVVGGEA
                     SINEKSLDTIKSNNISVSRISGSDRYQTSMNIAKELNNISNISKISVVNGEKGLADAV
                     SIGAVSAQNDMPIILTNENSNITEINNLFKNKKIDKSYVIGGEYTVSKNIESKLQNPQ
                     RISGSTRNETNAKVIKEFYKDSKIDNLYVAKNGMNKQDDLIDGLSVGVLAGKTKSPVM
                     LVGNSLDYNQKELFKTMRFKSVTQIGGNGNENSFKQIKEIA"
     gene            4842..5141
                     /locus_tag="KNP36_003478"
     CDS             4842..5141
                     /locus_tag="KNP36_003478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HBF0875307.1"
                     /translation="MYKNINKKQLKEMMKNEKDVLLLDVRTKDEFKEYKIENAINISL
                     QELINNIDEIYDYKDKKVVVYCRSGHRSVTACNLLAEEGFEHLYNLNSGIIDYMS"
     gene            complement(5380..7608)
                     /locus_tag="KNP36_003479"
     CDS             complement(5380..7608)
                     /locus_tag="KNP36_003479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="HBF0875308.1"
                     /translation="MRHLKKTNSLKEILNWNNIKNLRPSKGLKNILEIFKSDLKDIRG
                     NYAVLVIVLGLAFLPSLYAWFNIKASWDPYGSTANMLVAVTNEDKGNEIAGQKINVGD
                     QLIEQLKDNKSLGWQFVDEKTALEGVKKGTYYASLKIPKNFTKDLTSLITDDVKKGEI
                     IYTVNEKINAVAPKITDKGASTIQLQVNQTIVKTVSEIVLGISNGVGAGIEHSLPKLT
                     KVENSLIDLQKRFDHINKTVDLASDATSKLSDTVKDIKSDLPTIKKTLNDTKLLSSDL
                     KKFLEDTNDNLDELSPLIKSDLNLMVDLSSSASSLTLNLIDAVNSGSEDVPKLIDNLS
                     EKLSNLQSLNDTLVDFLTKLNQLTSNNRLDDVIDNLEDSSNKIDSSISTLNDIKNKVI
                     SGQQPSISALNNVLSLSNGIGRINLNILNNFDSKISKPINSIFANSIKVANDIITVLD
                     KAEAKLPKVEEILTTSLKLSGNAQESISLIRERLPLAKGMLDDLIDTLSKISNGEDMK
                     KLVSLLESDILTKSNFLKEPVEVKTEKLYPIENYGSAMTPFYSVLSTWVGILLISALL
                     STSVHGNYKPYEIYFGRGLTFLSIALVQGFIIGTGDILLLGVTAKHPILLIVLLMFTS
                     MVFNFIVYSLVSVFGNVGKAIAIVLLVVQIGSSGGTFPIQVTPTFFQRINPIMPFTYA
                     IGATREAVGGIYAPNLTKDILVLLLFMILSICLNVLLKGPINRVIKPFNDKFGDSNLT
                     GH"
BASE COUNT         2666 a         1100 c         1081 g         2843 t
ORIGIN      
        1 ttattatatc acttaaataa ttttttattt atataagaaa tctaataata aattactaga
       61 ggtatttaac tatttagaaa gaattggtat tatataaagt aagagaatat ataataagaa
      121 agaatatttg attttattgg aaaacaaaag aaaaagaagg tgattactat ttctcatata
      181 actgcgaaga atatgtataa aagtttagag gaaagaataa acaagtttcc acaaggtgct
      241 ccaccatctg atacattata caaaatacta aatgtactat atacagaaca agaggcgaag
      301 ttagttgctc agcttccaat aaagcctttc agagtaaaaa cagcagctaa aatttggagt
      361 gtaagtgaaa gtgaagcata tagagtattg gataaacttg ctagtaaggc tctgatacta
      421 gatatagaag ataataaagg gaagaaatat ataatgcctc ctccaatggc tggttttttt
      481 gagtttgcca tgatgagaac gagacacgat atagaccaaa aacttttggc agagctttac
      541 tatcaatata tgaatgtaga agaagatttt atcaaagatt tattttattc aacagaaacg
      601 aagcttggaa gagtatacgt tcaagaggaa gttttaacta atgataatga ggttagtatt
      661 ttagattatg aaagggctac tcatataatt gatgaatcaa ctcatatagg tataagtatg
      721 tgttactgta gacatagaat gcaacatgtt ggaaaagctt gtgatgctcc tatggatata
      781 tgtatgacgt ttgacaatgt agcaaattct ttaataaata ataaatttgc aagacgtgtg
      841 gataaaatag aatgtaaaga gctacttcat caagcatatg aacataactt agttcaatgt
      901 ggagaaaatg ttaggaaagg ggttacgttt atatgtaatt gctgtggatg ttgctgtgaa
      961 gcaatggtag cagctaaaag atttggaaat cttcatccag tacagacaac aagttttata
     1021 ccaaatataa accatgaaaa ttgtgtaaag tgtggtaaat gtataactgc atgtccaata
     1081 gatgcgataa gcaaggttaa ggaagatggt aaagaatata taaaaattga tgaggataga
     1141 tgtttaggtt gtggagtttg tgttagaaat tgccataaaa atagcattat gttattaaag
     1201 agagatgaaa aaataataac tccagcaaat tcagtacata gagcagttct tatggcaatt
     1261 gaaaaagggc agttacaaaa tttaattttt gataataatg ctctggctag tcatagagct
     1321 atgggagcta tactgtcagc tatattaaag cttgaaccag ctaaaaagat tttagccagt
     1381 aaacaattaa agtcagtata tttagataaa ttgttaagta tgaatgataa atagaaacta
     1441 acttaaaaaa ggcaaagttt tagacttatc tatatcttaa taaacttatc atttaatatt
     1501 taaatttaat ttttacacat ataaaactta taacttaaat aaaaaaaggc tatattcaat
     1561 taatattact tgaatacagc cttttttagt tatgttaagc tatttctttt atttgcttaa
     1621 atgagttttc atttccattt ccaccaattt gtgttacaga tttaaatctc atagttttaa
     1681 atagttcttt ttgattataa tctagtgagt ttcctactag cattacagga gatttagttt
     1741 ttccagccaa aactccaaca gataatccgt ctattaaatc atcttgttta ttcattccat
     1801 ttttagcaac atataaattg tctatcttag aatccttgta aaattctttt attacttttg
     1861 cattagtttc atttctagtg ctacctgata ttctctgtgg attttgaagt ttactttcta
     1921 tatttttaga aactgtatat tctccaccga ttacataaga tttatcaatc tttttgtttt
     1981 taaacaagtt atttatttca gttatattac tattttcatt agtaagtatt ataggcatat
     2041 cattttgagc tgatacagct ccaatgctta ctgcatcggc taatcctttt tcgccattaa
     2101 ctactgaaat ctttgatata ttgctaatat tgttcaattc tttagcaatg ttcatagaag
     2161 tttgatatct atcacttcct gaaattctag atacagagat attgtttgat tttatagtat
     2221 ctaaagattt ttcatttata gaagcttctc caccaactac atatacattt ttaactttta
     2281 atctctttaa ttcagccaaa gttttttcat ttatttgaga gcttccagtc aataatatag
     2341 gagcgttttt cttgtatgca aatggtgttg cagccaaagc atctgcaatt gctgaatcgt
     2401 ttattaaaac tgcattttca gcattttccc aacctgcttg acttatctta atagaagttt
     2461 catatctatc agttcctgta agtgcacttg catttacttc atcttgatat gtaacctcaa
     2521 atctagcatt tggacttcct aagaaaacaa ttacgcctcc ttttggcaat ctaactctat
     2581 tgttctttgt aactaaagaa tagtttacag gaacaccttt atcatcataa acagcaaaag
     2641 ctgaattttg aggaagatta acttctattt ttttatttgc gatatcgtca ccaatcttat
     2701 accattttgc ataaccattg gattctagtt cacaagtaaa agatttttct gctggcaaat
     2761 tagttataga atcttcacta acatacgtta gtgttccaaa agataaatac tctgtaccat
     2821 tttctttatg aagtttaatg tcggataaat cacgacctat tacaccaggt atttctataa
     2881 aagcatttga gttattctca tccattattt tagtgttaac tatataacct ggagtttcat
     2941 cagaaagagc aagagttgcc ttcacagaac caaacatata gctttgagaa gtatattttt
     3001 catctactag atagtaatct ttaccatttc tttttttcca tgcttctttt acactatttg
     3061 atatattgtt gtcatctatc ttttgagcta catagtataa acttgctgtc tgacctaatc
     3121 cagggacatc atcataagag ctcatattta aatatgtgat attgtttttt tcttttacaa
     3181 attttagaca gctgttacct ttttcagata caaatctatc ttgacctatg tatacgtatt
     3241 tatcttcagg tccattttct atataaggag aagatactgt taaagtacca ttatcattaa
     3301 catctacttt tatcatattt gaagaagcat aaagaccact attttctttt agagagctag
     3361 gcattttaac ttgttgtggt ttactaaatg ttttatcagg ttttatttct ttaattttac
     3421 ctttttcttt taatgcagat agtaagattt cttgtccaat tatttcatta agttgactac
     3481 ttccaccaga agaaagaact gcaactgcca tattttcatc tggaagaact ataagattac
     3541 tgtggaataa taaagagtct ccaccttttg taagagcttt taaattatac tgattaaatg
     3601 gataagtgtt gacacaatcc caccctaaac catatccaag tatagagtct tctccttcag
     3661 gccatagacc atttaaatat tctttgtttt ccatagcttt tactgaagca ggagaaagaa
     3721 taccatttga atttttcata aatgtttgtg caaatgtaca tagattttct gcacttgaat
     3781 ataaaccacc tgcacctata gcattaaggt tatcttgcgg aactgcatct tcccaataag
     3841 gcacgtatgc ttttgctagt tttgaactat caaaactatt ttctgtagtt tttgtatttt
     3901 gtaagttaag tggattattt atgtatttat caagaaaatt agtaaatgac ataccagata
     3961 ctctttctac taaaatttca gctaaagtaa atccatcatt acaataaacg gaaaaagctc
     4021 ctggtttagc ttttaatctt tgtttttgta attcttttaa gaaattatca tgaccataag
     4081 aatcattgtc tgctaataaa atagtgtttt taaaactact tcccatcaac cctgatgaat
     4141 gatttaataa cattcttgga gtgatttcct tgtatctatc atcagccatt ttaaattcag
     4201 gtatatactt tacaacagga gtatctaaat ttaattttcc atcatcaacc aacttcataa
     4261 cagctgttgt agtaaacatt ttactgatag atgcgatact atacatatta tccttattta
     4321 agtttttgtt atcctgtttg ctgtaaactc caccattacc agaaatctca attttgccat
     4381 tatcaatcaa agcatattga gcacttacag caccatactt tgatagcaaa gtttggattt
     4441 tctctttagc aagagcttta gtttttgtgt aagattccgc gtttttacta taatcatgta
     4501 attctatatc agaactttga tatttttcgg aattatcttt tgtattatca gcaaaagtaa
     4561 tatttggagc agcagtaaat aacatactca atactaatgt actagataat aatttagaga
     4621 gcctttgctt aaacatatta cattacctct ttcccttttt aataatttat aattagcata
     4681 acattcttaa ttattttaat caacagatta ttatcaataa aaaaagcttt tataagtata
     4741 gctttttata taacagagaa aaatataaaa ataatatttg ttgttgtata aagaataaag
     4801 ggtataggta atatataaat aaaatggagg aattttagac aatgtataag aatataaata
     4861 aaaagcaact taaagaaatg atgaaaaatg aaaaggatgt tttattatta gatgtaagaa
     4921 ctaaagatga atttaaggaa tataaaatag aaaatgctat aaatatatct ttacaagagt
     4981 taatcaataa tatagatgaa atttacgatt ataaagataa gaaagtagta gtttattgca
     5041 gaagtggtca tagaagtgtt actgcatgta atttgttagc tgaagaaggt tttgagcatt
     5101 tatataattt aaattcagga ataattgatt atatgagtta aataatgtaa gttatacatt
     5161 aaatactatg tatagctctg cttattaagt aggaatatat ctaaatattt ataagataaa
     5221 tttaggaaag aacgaatttt ttcgtttttt tctatgacag tttttgtagt aaatattagt
     5281 ttttaagttg gaaaaaggta gtagcttttt agctactacc ttttaatatg aacttagaat
     5341 attattaaaa aaaatatatt taaagacaga attaattttt taatgaccag ttaaattact
     5401 atcgccgaat ttatcattaa atggttttat aactctattt ataggtcctt ttagaagtac
     5461 atttaaacaa atagacagaa tcataaatag taatagaact agtatatctt tagttagatt
     5521 tggagcatat ataccaccaa ctgcttccct tgtagcacct attgcatagg taaatggcat
     5581 tatagggttt attctttgga agaatgtagg tgtaacctgt atagggaatg taccaccaga
     5641 agaaccaatc tgaacgacta atagtactat tgcaattgct tttcctacat ttccaaatac
     5701 agaaactaaa gaatacacta taaagttaaa taccatacta gtaaacataa gcagaactat
     5761 caataaaatt ggatgttttg ctgttactcc taacaataat atatctccag ttcctattat
     5821 aaaaccttgg acaagagcta tacttaaaaa agtaaggcct cttccaaagt aaatttcata
     5881 aggtttatag tttccatgta cagatgtaga caatagtgct gaaataagta atataccaac
     5941 ccatgtagaa agaacactat aaaatggtgt cattgcagaa ccataatttt caattggata
     6001 taatttctct gttttcacct caacaggttc ttttaagaaa ttagactttg tcaatatatc
     6061 actttcaagc aagctgacta attttttcat atcttcacca ttactaattt tgcttaaagt
     6121 atcaatcaaa tcatccaaca ttccttttgc taaaggaagt ctttctctta tcaatgatat
     6181 actttcctgt gcatttcctg aaagttttag agaagtagta agtatttctt caacctttgg
     6241 aagttttgct tctgccttat ctaaaacagt aattatatca tttgctactt ttatactgtt
     6301 tgcaaatata ctatttatag gttttgatat ttttgagtca aaattattta aaatatttaa
     6361 attaattctt ccaataccat ttgatagact taaaacatta ttcaaagcac ttatagatgg
     6421 ttgttgtcca gatataactt tgtttttaat atcatttaat gttgatatag atgaatctat
     6481 tttattgcta gagtcttcaa gattatctat tacatcatcc aatctattat ttgatgtaag
     6541 ttggtttaat ttagttaaaa agtccaccaa agtatcgttt aaagattgca aattagaaag
     6601 tttttctgat aaattatcta tcaacttagg tacatcttca ctgccactat ttactgcatc
     6661 aattaaattt aatgtaagag aagaagcaga agatgaaagg tcaaccatta aatttaagtc
     6721 agacttaata agaggagaaa gttcgtctaa attatcattt gtatcctcta agaatttttt
     6781 taagtcactt gataatagtt ttgtatcatt cagagtcttt ttaattgtag gtaaatcaga
     6841 tttaatatct ttaactgtat cagataattt tgaagtagca tcagaagcta aatcaacagt
     6901 cttatttata tggtcaaatc tcttttgaag gtcaataagg gaattttcaa cttttgtcaa
     6961 ttttggaaga ctgtgttcaa ttcctgcacc aactccgttt gatataccaa gaacgatttc
     7021 actaactgtt tttactatag tctgattaac ctgtagttgt attgtagaag cacctttatc
     7081 tgtaatcttt ggtgcaactg catttatttt ttcattaaca gtatagataa tttcgccttt
     7141 tttaacatca tctgtaatta aagatgtcaa atcttttgta aaattttttg gaatcttaag
     7201 tgatgcataa taagtacctt ttttaacacc ttcaagagca gttttttcat ctacaaactg
     7261 ccaacctaaa ctcttgttat ctttgagttg ttcaattaat tggtctccta cattaatctt
     7321 ttgtcctgct atttcatttc ctttatcttc atttgttact gctacaagca tattagcagt
     7381 gcttccataa gggtcccaag atgcctttat attgaaccaa gcatacagag atggtaaaaa
     7441 agcaagacct aaaactatta caagtacggc ataattgcca cgtatatctt ttaggtcact
     7501 tttaaaaatt tctaatatat tttttaaacc ctttgaaggt cttaaattct tgatattatt
     7561 ccagtttaaa atttctttta aactattagt ttttttcaaa tgtctcacct cctaaaatat
     7621 tttgataaag aaaaaagtta gatttataat caattttaaa ttatattact ttttacacaa
     7681 atagtaaagt
//
LOCUS       DAEHWM010000141         7688 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.144, whole genome shotgun sequence.
ACCESSION   DAEHWM010000141 DAEHWM010000000
VERSION     DAEHWM010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7688)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7688)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7688
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.144"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1106
                     /locus_tag="KNP36_003480"
     CDS             <1..1106
                     /locus_tag="KNP36_003480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875309.1"
                     /translation="NGVGAGGGGSGYVLTKDSYKPTGYTPTSEYYFDNVVMESGGNTA
                     GAYGYAKITLLQALPFLTVSSYNSITATFKADHTDPTLLTKIEYFIDDILKETITTDL
                     TTEKTINYTLEDNALHTLKIVVTDSNNTTAEKVLSISKNIMPLPENVNLNDISTKLVE
                     VNAGFKVGKTSIINTLALKNIEASLNNTLVELSEKIKTSFDSSDASVQDLMNQLTQAN
                     NTISQLNSKYKYATGTAYARENSSLIACVYDPNTSHTVTETSPYWLDLNGIGFIPDIF
                     FAECEYEPHSNAFYKYFVFAIKNTFPISNNTGFVVNIAFNKEYGDESFKLRGALYTLG
                     KRHVSMDNNGVRVPSLSTLNDFRAYKWHAIKFK"
     gene            1120..1413
                     /locus_tag="KNP36_003481"
     CDS             1120..1413
                     /locus_tag="KNP36_003481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875310.1"
                     /translation="MNRANRIIYDQTGKILLQTGEATGDILEHDTITELHYIDVEYGN
                     IDYSKQYIESINPITKEPILKDIPIYLSEEEKRIQELENQILLNENEKVGGLL"
     gene            1413..1595
                     /locus_tag="KNP36_003482"
     CDS             1413..1595
                     /locus_tag="KNP36_003482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015981517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875311.1"
                     /translation="MNINNVVVRILAERILSRGLNPLKNRPFELDDVTNEDYRKAVED
                     CIIKESGVVERVETTK"
     gene            1623..3524
                     /locus_tag="KNP36_003483"
     CDS             1623..3524
                     /locus_tag="KNP36_003483"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875312.1"
                     /translation="MIYKDLLKKVNDIENLKEVDNIKCSTDTGEYTIENSKKGYLTNF
                     NVEGKTLIDLWGKTSSDFSLWKATFVDGKINILTENDIRYSNFFTINYTSYKPDTIYT
                     IIVDVDKNTLPSTSGIYIHSLGEENSVFIPNLTNIAIPGGVIGKFKYTFTTISDLNDC
                     NVVLRSVLDNDTLTSGYEISLKITILEGDYTDINIDYSNELLSVGQRDKIEFLSYQYS
                     GINIFNKNADFKDNYILQYLSGEELISEASNHKYTLDYIEIEPDTEYTFYNCSRNICW
                     YDINKNFIPASLNERIIGDKDIFYIARSPKNAKYLRVTIIKDLHDNGNKTIITKGNKY
                     DKKTIPYTLRSLPNGVKDEIVYKNDKYYLIKRCEEHTYTDIGNLNLSHVYDNTLQFMG
                     TLTPQAVVDSLDTAYVLCNNLNGKSRNDFNNNDIEGCSTTGSGDIAFKILKSKLTTQD
                     GNGFSEWIKNNPITIIYQLSKPQEIELTSLNLEQYNNQTKFICNTGIVIPDISFESTQ
                     NLGSHIEVIRNNIKNYNVRTDFPFSINFLNGWQPYLGYASSVGNYCTNNNLVTINATI
                     NGGITTAGTIIGKIPSKYAPRKGIIVIFQTTDGKYYNGIIRTNGEIEIYYNDITYRSW
                     LYLYVNYLI"
     gene            3539..3859
                     /locus_tag="KNP36_003484"
     CDS             3539..3859
                     /locus_tag="KNP36_003484"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875313.1"
                     /translation="MDIEKKIEILIEYGFENDLNNIDNYFIAEGKKIFTPVIKNGELI
                     KTGEQVYNEWIELQNNPPKPSIEEINADKITILIENQKQQDSLLVDNAYRIAMLELNT
                     NNVL"
     gene            3885..4055
                     /locus_tag="KNP36_003485"
     CDS             3885..4055
                     /locus_tag="KNP36_003485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875314.1"
                     /translation="MYNILKRMIEQKNYETREELQTKLDVFYAMNRIKESEYTELTNL
                     LNKEDTLVEPII"
     gene            4136..4951
                     /locus_tag="KNP36_003486"
     CDS             4136..4951
                     /locus_tag="KNP36_003486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0875315.1"
                     /translation="MNIKTLTIHAGHNPDNKIGSGAIGNIKESTEARNVLKELLPLAQ
                     KECKVYDCTCNNGTSQSDILNKIIAKCNSYNTDLNVSIHFNSGGGRGVEVLVYNLNDK
                     ETVEIASRICKKITETYHAKGDKDFKNRGVKEKKTLAFLRRTKAKSILVECCFVDTSD
                     TKKYNTKDMAIDIYEGIFNKSVAGKPQDNKVKYAIVYEGDVDKVIAQLMAMNYKTNEV
                     SVCDLKNYVPGHCENLYVIGGASSKIKTSERFTKLQGDDRWATLHKVLDFIGK"
     gene            4963..5580
                     /locus_tag="KNP36_003487"
     CDS             4963..5580
                     /locus_tag="KNP36_003487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HBF0875316.1"
                     /translation="MNILDKSTATLEQVFSYLDTLKNNSNPPHFLCRAIVPIIYKEAE
                     KKGVNPVIAIAQAFVETGYFNFGRVLNPSYCNVCGLKGNKGGGDLDPTAHTRFNCWED
                     GVSAFIDHLALYAGAKGYPKYNELVGKVEYKVNGTTLDPRHFSYLHGEAKTVESLSGK
                     WCPDTNYGQNIINICNKISSMKVENNDIKLEQIKTKVKELNEILG"
     gene            5592..5843
                     /locus_tag="KNP36_003488"
     CDS             5592..5843
                     /locus_tag="KNP36_003488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HBF0875317.1"
                     /translation="MDIMQFIPENLIMLIGGLYILGTFIKESNIKNKYIPFILLVIAM
                     ISSCLFMKELSIEAVFEGILCWGASIGINQIQVQNRKDK"
     gene            5844..6155
                     /locus_tag="KNP36_003489"
     CDS             5844..6155
                     /locus_tag="KNP36_003489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875318.1"
                     /translation="MLSKEMVELLSQYGYTAILLMVLMLWLGKYLEKNRQLEQDDRKK
                     ERAYFSREIKEQRTLFGNTIDKFDDKLDKFAEALNTNNSRLERVETDITKIKDKLETR
                     D"
     gene            6189..7124
                     /locus_tag="KNP36_003490"
     CDS             6189..7124
                     /locus_tag="KNP36_003490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HBF0875319.1"
                     /translation="MAKQRSKRISINGEPNPENIKLWKQYKRAKQIAGKSEKTIYNYE
                     CDIMQFFKFLNIECFDTLLTDINEEEIEAYIGYCMEQGNNEKRIRRRISSISSLLSFL
                     KKKRKITDNWCEMIERPGTGEEVQKRTFLTEEQLRKLKEKLSEQDNLQLEVYINLGLA
                     TMARSNEISQFRWDNIDLDNRWIHGITAKGGVSRDFRFSEEVQHLLIEWKDYLSQNNI
                     DYPYIFFTRYGGKYNQVNSNVLSSWVKKAFRLIGIEGGYNHDLRHSMSNLLKDRGVPI
                     TTVSKLLGHSGVDVTINHYTIENKNKLAEEYDKFM"
BASE COUNT         3219 a          821 c         1282 g         2366 t
ORIGIN      
        1 tgaatggtgt gggagcaggt ggaggtggaa gtggctacgt attaactaaa gatagttata
       61 agcctactgg ctacacacca acatctgaat attattttga taatgttgtt atggaatctg
      121 gtggaaatac tgctggtgct tatggttatg ctaaaataac attactacaa gcattaccat
      181 ttttaacagt atcttcttat aattccatta cagctacatt taaagctgac cacacagacc
      241 ctacactatt aactaaaata gaatacttta tagatgatat actaaaagaa actataacaa
      301 cagatttaac aacagagaaa acaattaact acacattaga agataatgca ctacacacac
      361 ttaaaatagt tgttacagac agtaataata ctacagcaga aaaagtatta agtataagta
      421 agaatataat gccactaccc gaaaatgtaa atttaaatga tatatcaaca aaattagttg
      481 aggttaatgc aggatttaaa gttgggaaaa caagtattat aaatacttta gcattaaaga
      541 atatagaagc aagtttaaat aatacacttg ttgagttgtc agagaaaata aaaacaagtt
      601 ttgatagttc agacgctagt gtgcaggatt tgatgaacca gttaacacaa gctaataata
      661 ctatatcaca gttaaattct aagtataaat atgcaacagg aactgcttat gctagagaaa
      721 attcatcctt aattgcatgt gtatatgacc ctaatacttc tcatactgtt acagaaacga
      781 gcccttattg gcttgattta aatggaattg gatttattcc tgatatattt tttgctgaat
      841 gtgaatatga accacattcg aatgcttttt ataagtattt tgtttttgca attaaaaata
      901 cttttcccat ttctaataat actgggtttg tagttaatat tgcttttaac aaggaatatg
      961 gtgatgaatc ttttaaatta cgaggagctt tatataccct tggcaaaaga catgtttcca
     1021 tggataataa tggagttaga gtaccttcac taagcactct aaatgatttt agagcatata
     1081 aatggcatgc gataaaattt aaataaatga ggtgataaaa tgaatagagc aaatagaata
     1141 atttacgacc aaactggtaa aatattactc caaacaggag aagcaacagg agatatatta
     1201 gagcatgata caataacaga attacattat attgatgttg aatatggaaa tatagactat
     1261 agtaaacagt atatagaatc tataaatcca ataacaaaag aacctatttt aaaagatatt
     1321 ccaatctatt taagcgaaga agaaaagaga atacaagagt tagaaaatca aatattacta
     1381 aatgaaaatg aaaaagtagg agggctatta taatgaatat aaataatgtt gtagtaagaa
     1441 tattagcaga gaggatttta agtagaggat tgaatccttt aaaaaataga ccttttgaat
     1501 tagatgatgt aactaacgag gattatagaa aagcagtaga agattgtata attaaagaaa
     1561 gtggagtagt agaaagagta gaaactacaa aataggggtt ttgtgaagag aggtgtttta
     1621 atttgatata taaagattta cttaaaaagg tcaatgatat agaaaatctc aaggaggttg
     1681 acaatataaa atgtagtact gatacaggag aatatactat agaaaatagt aaaaagggct
     1741 atttaactaa ttttaatgta gaaggaaaga cattaattga tttatgggga aaaactagtt
     1801 cagatttttc tttatggaaa gcaacttttg tggatggaaa aataaatata ctaacagaaa
     1861 atgatataag atattctaat ttttttacaa tcaattacac ttcatataaa ccagatacca
     1921 tatatacaat catagttgat gttgataaaa acactttacc gagtacaagt ggaatatata
     1981 ttcatagctt aggcgaagaa aattcagtat ttattcctaa tctgacaaat atagctatac
     2041 caggaggagt aattggtaaa tttaaatata catttacaac aatatcagac ttaaatgatt
     2101 gtaatgttgt tttaaggagt gttttagata acgatacact tacatctggt tatgaaataa
     2161 gtttgaaaat taccatatta gaaggagatt atacagatat taatatagat tactctaatg
     2221 aactattaag tgttgggcaa agagataaaa tagaattttt aagttatcaa tatagtggaa
     2281 ttaatatctt taataagaat gccgatttta aagataatta tattttacaa tatcttagtg
     2341 gagaggaact tatttctgaa gctagtaatc ataaatatac cctagactat atagaaatag
     2401 aaccagatac agagtatact ttttataatt gcagtagaaa tatttgttgg tatgatataa
     2461 ataaaaattt tataccagca tcattaaacg aaagaataat aggagataaa gatatttttt
     2521 atattgctag aagccctaaa aatgcaaagt atctaagagt tactataata aaagatttac
     2581 atgataatgg gaataaaaca attataacta aaggaaataa atatgataaa aagacaattc
     2641 catatacatt aagaagttta ccaaatggag taaaagatga aatagtttat aaaaatgata
     2701 aatattactt aataaaaaga tgtgaggaac atacttatac tgatattgga aatcttaatt
     2761 tatcacatgt atatgataat actctgcaat ttatgggaac attaactcct caagctgttg
     2821 tagatagttt agacacagca tatgttttat gtaataattt aaatgggaaa agtagaaatg
     2881 attttaacaa taatgacata gagggatgct caactactgg tagtggtgat atagcattta
     2941 aaatattaaa aagtaaactt actacacaag atggaaatgg gtttagtgaa tggataaaaa
     3001 ataatccaat aactatcatc tatcaacttt caaaaccaca agaaattgaa ttaacatcac
     3061 taaatttaga acaatataat aatcaaacta aatttatttg caacacaggt attgtgatac
     3121 cagacattag ttttgaaagt acacaaaatt taggaagtca tatagaagtt atcagaaata
     3181 atataaaaaa ttacaatgtt agaactgatt ttccattttc aataaacttt cttaatgggt
     3241 ggcagccata tcttggatat gctagttctg ttggaaacta ttgcacaaat aataaccttg
     3301 taacaattaa tgcaactatt aatggaggta ttacaacggc aggtactatc attggaaaga
     3361 taccttcaaa atatgcacct cgtaaaggca taatagtaat atttcaaaca acagatggaa
     3421 agtattataa cggaatcatc cgtacaaatg gagaaattga gatatattat aatgatataa
     3481 cttatcgtag ttggttgtat ttatatgtaa actatttaat ttagaaagga aaaataagat
     3541 ggatatagaa aagaaaatag aaattttaat agaatatgga tttgagaatg atttaaataa
     3601 tatagataat tactttattg cagagggtaa aaaaatattt actccagtga taaaaaacgg
     3661 agagctaatt aaaacaggag aacaggttta taatgagtgg atagaattac aaaataatcc
     3721 acctaaacca agcatagagg aaataaatgc ggataaaatt acaattttaa tagaaaatca
     3781 aaaacagcaa gacagtttat tagtagataa tgcttataga attgctatgt tagagcttaa
     3841 cacaaataac gtgttataaa attataaaaa atggagggaa caacatgtat aatattttaa
     3901 aaagaatgat tgaacaaaag aattatgaaa ctagagaaga attgcaaact aagttagatg
     3961 tattttacgc tatgaacagg ataaaggaaa gtgaatacac agagttaaca aatttattaa
     4021 ataaagaaga tacactagta gaacctatta tctaaagtat aaaggttctt tttttatgtc
     4081 aattttagag gattgattaa tttcaattct cttttaatta aaaggagtgg taattttgaa
     4141 tataaaaaca ttaacaattc atgcaggaca taatccagat aataagatag gttctggagc
     4201 aataggaaat ataaaggaat ctacagaagc aagaaatgta ctaaaagagt tattaccttt
     4261 agctcaaaag gaatgtaaag tttatgactg tacttgtaac aatggaactt ctcaaagtga
     4321 tatattgaat aaaattatag ctaaatgtaa ttcatataat actgatctaa atgtaagtat
     4381 ccatttcaac agtggtggtg gtcgaggagt agaagtttta gtttataatt taaatgacaa
     4441 agaaactgtt gaaatagcat caagaatatg taaaaaaata actgaaactt atcatgcaaa
     4501 aggtgataaa gattttaaaa atcgtggagt taaagaaaag aaaactctag catttttaag
     4561 aagaacgaag gcaaagtcaa ttttagttga gtgctgtttt gtagacacat ctgacactaa
     4621 aaaatataat actaaagata tggctataga tatttatgaa ggaatattta ataagtctgt
     4681 agctggtaaa ccacaagata acaaagtgaa atatgcaata gtttatgagg gtgatgtaga
     4741 taaagttata gcccaattaa tggccatgaa ttataagact aatgaagtct ctgtgtgtga
     4801 tttgaaaaat tatgttcctg gacattgtga aaacctatat gtgattggtg gagcatccag
     4861 taaaattaaa actagcgaga gattcactaa gttacagggc gatgatagat gggctacact
     4921 tcataaagtg ttagatttta taggcaagta ggaggtaatg aattgaatat attagataaa
     4981 tcaacagcta cattagaaca agtcttttcg tatttagaca cattaaaaaa taactctaat
     5041 ccaccacatt ttttatgcag agctatagta ccaattatat ataaagaagc agagaaaaaa
     5101 ggtgtaaatc cagttattgc aattgctcaa gcatttgtag aaactggata ttttaatttt
     5161 ggtagagttt taaatccttc ttattgcaat gtgtgtggtc ttaaaggaaa taaaggtgga
     5221 ggagatttag acccaacagc tcatacaaga tttaattgtt gggaggatgg agtatcagca
     5281 tttattgacc atctagcatt atatgctgga gctaagggat atccaaaata caatgaatta
     5341 gttggtaaag ttgaatataa agtcaatgga actacattag accctagaca tttttcatat
     5401 ctacatggag aagctaaaac agttgaaagc ttatcaggta aatggtgtcc agatacaaac
     5461 tatggtcaaa acataataaa tatatgcaat aagataagtt caatgaaggt agaaaacaat
     5521 gatataaaac tagagcaaat aaaaactaaa gtaaaagaat taaatgagat tcttggatag
     5581 gaggaaatca catggatata atgcaattta tacctgaaaa tttaataatg ttaataggtg
     5641 ggctttacat attaggaaca tttataaaag aatctaatat taaaaataaa tacatacctt
     5701 ttatattgtt agttatagca atgataagta gttgtttgtt tatgaaagag ctgtcaatag
     5761 aagctgtctt tgaaggtatt ttatgttggg gtgcatctat aggaataaat caaatacaag
     5821 tgcaaaacag aaaggataag tagatgttat caaaagaaat ggttgaatta ctaagtcaat
     5881 atggatatac agctatactt ttaatggtac tgatgttatg gcttggaaaa tatttagaga
     5941 aaaatagaca actagaacaa gatgatagaa aaaaggaaag agcttatttt tcaagagaaa
     6001 ttaaagagca gagaacttta tttggtaata caatagataa gtttgatgat aaattagata
     6061 aatttgctga agcattaaat actaataaca gtagacttga aagagttgaa acagacataa
     6121 caaaaattaa agataaatta gagactagag attaatttct ctagtctttt tataaggaag
     6181 tgaagtattt ggcaaaacaa cgcagtaaaa gaataagcat aaatggagaa ccaaatccag
     6241 agaatattaa attatggaag caatacaaaa gagcaaaaca aatagctggg aaaagtgaaa
     6301 aaacaatata taattatgaa tgtgatataa tgcaattttt taagttttta aatatagaat
     6361 gttttgatac attactaact gatataaatg aagaagaaat agaagcttat ataggttatt
     6421 gtatggaaca gggaaataat gaaaaaagaa ttagacgtag aataagttca atttcatcat
     6481 tgctatcatt tttaaagaag aagaggaaaa ttactgacaa ctggtgtgaa atgatagaaa
     6541 gaccaggaac aggcgaagaa gttcagaaaa gaactttttt aactgaagaa cagttacgca
     6601 aattaaaaga aaagctttca gagcaagaca atttacagtt agaagtttat ataaatttag
     6661 gattggctac aatggctaga agtaatgaga taagtcaatt tagatgggac aatatagatt
     6721 tagataatag atggattcat ggtattacag ccaaaggtgg agtttcaaga gattttagat
     6781 tttcagaaga agtccagcat ctattaatag aatggaagga ttatctatct caaaataata
     6841 tagattatcc gtatatattc tttacaagat atggaggcaa atacaatcaa gtcaattcaa
     6901 atgtcttaag ttcatgggtt aaaaaagctt tcaggttaat tggtatagaa ggtggatata
     6961 atcatgacct tagacatagt atgtctaatc ttttaaaaga cagaggagtt ccaataacta
     7021 cagtttcaaa attgcttggc cacagtgggg ttgatgtaac tataaatcac tacacaatag
     7081 aaaataaaaa taaattagct gaggaatatg ataagtttat gtaaattgaa aggaagtggt
     7141 atcatggcat gtaaaggtcg taaaaaaggt aagaaaaaga gatagataaa taataaagcc
     7201 ctctagggat tactcttaat tgagttttct ttagagggct ttattttttt atatatgttt
     7261 atataaattt ataattatat ataatgctaa accacttaaa atacttttca aaaaaaatga
     7321 ttttatttga aattttttaa ataaaacatc agaaacataa aatacagcac atgctataaa
     7381 aaaatataaa aattcattat taattcctgc caatctaata tgtatgatag taaataatat
     7441 tataataatc aaaaacgtat ctataaaatt tttgtgtttt cattcaatat attaaactta
     7501 ttttaattag gtatctatct caagtctatc ctaatagtat agaatatgta agaaattatt
     7561 aattaataat tcttaactat caataaacta atcttaatta tttattaata tttcttaatt
     7621 atatatatga atgcataact ataataaaag tattaaaaaa caatctaaaa atcgatttaa
     7681 ataaatat
//
LOCUS       DAEHWM010000142         7317 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.145, whole genome shotgun sequence.
ACCESSION   DAEHWM010000142 DAEHWM010000000
VERSION     DAEHWM010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7317)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7317)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7317
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.145"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            467..976
                     /locus_tag="KNP36_003491"
     CDS             467..976
                     /locus_tag="KNP36_003491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009528606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HBF0875320.1"
                     /translation="MSKELAINEQIKDKEIRVLSPTGEQLGVMPTKEAQAMANSKNLD
                     LVQISPNANPPVCKIMDYGKFRYEQARKEKEAKKKQKTIVVKEVRLRPGIEQNDLNTK
                     ANNAIKFLKKGDKVKVELRFRGRELGHKDIGKEVMLKFLDIIKEFGEPTKAPAFEGNN
                     MVVIIDPKK"
     gene            1004..1198
                     /gene="rpmI"
                     /locus_tag="KNP36_003492"
     CDS             1004..1198
                     /gene="rpmI"
                     /locus_tag="KNP36_003492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011721840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HBF0875321.1"
                     /translation="MPKMKTHRGAAKRLKKTGTGKLKRAKAFKKHILTKKSAKTKMNL
                     RKSTLVSDGDAKRIAQLLPY"
     gene            1254..1610
                     /gene="rplT"
                     /locus_tag="KNP36_003493"
     CDS             1254..1610
                     /gene="rplT"
                     /locus_tag="KNP36_003493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HBF0875322.1"
                     /translation="MARVKKAMNARKKHKKILKLAKGFRGSRSKLYRPANTFVMKALK
                     NAYIGRKLKKRDFRKLWIQRINAAARMNGISYSRLMNGLKLSGVEVNRKMLSEMAIQD
                     PEGFAKLAEVAKAKLA"
     gene            1920..2465
                     /locus_tag="KNP36_003494"
     CDS             1920..2465
                     /locus_tag="KNP36_003494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875323.1"
                     /translation="MNEKLMDCFVNPIKCKLLIEIFSNNRTTAKQLGEKFQDISKATL
                     YRYLNKMLKDDIIKVVEENKIRGTVEKVYAMKLDIADDVNKIIDENSGEEYAQLFTQY
                     MMGFLREFYEYAERKEKDILKDGSGFSVCPVYASIDEIVEVSKKIASILEPLRNNSHE
                     EGRRMHSIGVIITPPKKDEGK"
     gene            2900..4825
                     /locus_tag="KNP36_003495"
     CDS             2900..4825
                     /locus_tag="KNP36_003495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0875324.1"
                     /translation="MKIKFVIMPLVIFLMVLFVGCQSTKDTEVKAKDTEIKILGTGDL
                     HSILTDSMVSYVNEEREKNKNLLMVDAGDFYGTQSREMWEWSSGKKLINIKRNGRAEY
                     DDIIKSSKDEVPIVKDMAKLKYDAVVLGDNEFVSNDKQSLDKLVSDFKNNNMPLVSAN
                     IYEQSGENYVQPYVMKNIKTDEGNVKVGILGLTIKEVGETLGLEDFEKDKKARELGEQ
                     ADYKGKLYANDLVEDAKKWIKVMEKESPDIIVAVVHSGEEPKTDRNPGNRIKELATTV
                     DGIDAIVAGHTHEKIDEHKYKNKSGDEVIVTQPGWHGDRVSEINFKLNKENGKWDIKE
                     KSSKLKIIDKEVSIVATADLHSHFSDKLTVDLVNERSNPIEPVVVDAGDFLDPQTDEM
                     TQWYKEWKSIRDNNSDKTISRCPMVMDMNQGMYDAVVLGNHEFVSEKDEFWSDERLLD
                     AVIEDFEQVAISVLSANIYRQSGKNYVKPYIIKDVETSEGNVKVGILGLTIKEVGKGL
                     KNVNLQEQFQYKDKLYANDLVEDAKKWVKVMKKKKPDIIVAVVHSGEEPKNPKHPGNR
                     IKELATTVDGIDAIVASHTHEKIDEHEYKNKSGEKVIVTQPGEHGKYYSKITFKVNKE
                     KGSWTINDKFSKTIEVE"
     gene            5226..7130
                     /locus_tag="KNP36_003496"
     CDS             5226..7130
                     /locus_tag="KNP36_003496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HBF0875325.1"
                     /translation="MKIKFIIVASIIFLIVLLVGCQSTKDTEINVLATSDLHSIIPDN
                     LISYVEEERKYDENLLMVDAGDFFDMQSGEMNKWFTGQKLVRFKDGIPEYKKIAEPRE
                     GEVPLAKKMAKLKYDAVTFGNHEFVSNDKQSLDKLVSDFKNNNIPLVSANVYEQSGEN
                     YVKPYVMKNINTDKGTVKVGILGLTIKEVGERSRFKSFEQDKKARELGEQPQYKGKLY
                     ANDLVEDANKWVNVMEKKEKPDIIVAIVHSGEEPKNPKNPGNRIKELATTVEGIDAIV
                     AGHTHEKIEQHTYKNNSGEEVIVTQPGAHGNSISKINFKLDKKNDKWFIKDKYSELKV
                     FGKEVNIITTSGLNPKFSDEMAVNLFNERDRDVQPIFIDTGDFLNTNTKEMTKWAKEW
                     QYNENKGIYKKINEWPIVYLGYDAVVLGSHEFTEDKETFEEKKSTLDYIIENFEEMKI
                     PVLSANIYDESGENYVKPYIIHNVETREGNIKVGVLGLTTTDKDEEDLSNSSLSKDSK
                     TSKIPEETGKLYTNNLVKDASEWVKVMQKESPDVIVVVVHSDNNSTLKNPSSEVKKLA
                     MSVDGIDAIVVGHTKNKVEEHIYKNKSGDEVIVTQSGEDCYSKISLELRKENGKWNII
                     NKYSKAIKMK"
BASE COUNT         3082 a          731 c         1361 g         2143 t
ORIGIN      
        1 tagtatatta gagtacaata tagaatttgt tatgtagtat agtagtatat tagaatacaa
       61 tatagaattt gttgggtagt atagtgttat attagaatac aatataggat ttgttatgta
      121 gaatatatag agtcatgtag aatatacata tataaaagga ttttgggtat aaatttaaaa
      181 attaatagca aaatgagtag tatagacata taattagtag taggaagtaa ttaaattttt
      241 cctaaacaaa aaaaatagtt gcaaataatt tgattaagtg atatagtaaa taaggtaaga
      301 ataaaacaaa gaagaagtcc gcttctcacc ttacgccgga ggttagtaag gtaaatataa
      361 gttaaagctt aattttaatt taagtttgtt taaatttggt aacttatatt gcggatgatt
      421 acgtcatccg ctttttattt tataaaaatt ttggaggtgt cctacaatta gcaaagaatt
      481 agcaatcaat gaacaaataa aagataagga aataagagtc ctttcaccaa caggtgaaca
      541 acttggagta atgcctacta aagaagctca agcaatggct aatagcaaaa acttagattt
      601 ggttcaaatc tcgccgaatg caaatccacc agtatgtaag ataatggatt atggaaagtt
      661 tagatatgag caagcgagaa aagagaaaga agctaagaaa aaacaaaaaa ctatagttgt
      721 aaaagaagta agacttagac caggtattga acaaaatgat ttaaatacga aagctaataa
      781 tgctataaag ttccttaaaa aaggggataa agtcaaagtt gaacttagat ttagaggaag
      841 agaattagga cataaagaca taggtaaaga agttatgctt aagtttttag atataataaa
      901 agagtttgga gaaccaacaa aagcccctgc atttgagggt aataatatgg ttgtaattat
      961 agatccaaaa aaatagatga ttaactgaga ggaggaattt gtcatgccta aaatgaaaac
     1021 tcatagaggt gcagcaaaga gattaaagaa aacaggaact ggaaagttaa agagagctaa
     1081 agcttttaaa aaacatatat taactaaaaa atctgcaaaa actaaaatga acttaagaaa
     1141 atcaacttta gtaagtgatg gagatgctaa gagaatagca caattattac catactaaga
     1201 tacagattgt aaataataac tatagaagag ggatataaaa ggaggtcata acgatggcaa
     1261 gagttaaaaa agctatgaac gctcgtaaaa agcataagaa aatattaaaa cttgcaaaag
     1321 gattcagagg atctagaagc aaattatata gaccagcaaa tacattcgta atgaaagcat
     1381 taaaaaatgc ttatatagga agaaagttaa agaagagaga cttcagaaaa ctttggatac
     1441 aaagaataaa tgcagctgct agaatgaatg gaatatctta ttcaagatta atgaatggat
     1501 taaaattatc tggtgttgaa gttaacagaa aaatgttatc tgaaatggct atacaagacc
     1561 cagaaggatt tgcaaaatta gcagaagttg ctaaagcaaa attagcttag tattgaatca
     1621 tgagatgtaa agtctttgag ttatataaat aattcaagga cttttttatt ttttgaaaaa
     1681 tacttattag tgtcatgtac aaccaatttt ataatgataa ataaaataag caatacaata
     1741 gaattttatg agatttatta taagaattgt tacaattatt tatgatagct ataaaaagtc
     1801 atagtaaaaa tgatattgat gtatgttgat atatgtataa agtttccaat caatcttgaa
     1861 ttaatattat caacatgata atattatctt attaataata taaataaggg ggacataata
     1921 tgaatgaaaa actaatggat tgttttgtaa acccaattaa atgcaagtta ttgattgaaa
     1981 ttttttcaaa taatcgaact acagctaaac aattaggaga aaaatttcaa gatatatcaa
     2041 aggcaacact ttatcgttac cttaataaaa tgttgaaaga tgatattata aaagtggttg
     2101 aagaaaataa aataagggga actgttgaaa aagtatatgc tatgaagtta gatatagctg
     2161 atgatgtgaa caaaattata gatgagaact ctggagaaga atatgctcaa ctgtttactc
     2221 aatatatgat gggattttta agagaatttt atgaatacgc tgaaagaaag gaaaaggata
     2281 tcctaaaaga tggttcagga ttttctgtct gtccagtata tgctagtatt gatgagatag
     2341 ttgaagtgag taaaaaaatt gctagtatac tagaacctct aagaaataac tcacatgaag
     2401 aaggtagaag aatgcattct ataggagtga taattactcc acctaaaaag gatgaaggga
     2461 aataaatctg atttacatgg ggtagagcca atttatacag ggaatcgttt tatgatttac
     2521 atatgtatcc agagcaaagt atctctgctt ggattgtact tcattgtacc atttcatcca
     2581 atgacttgga gtggtacaat gaagtttttt aatttttcat attaatgcta aagaaatgaa
     2641 ctttagacca catatgcaat taggttgcat tatacaatta gaccacatat acaaaataaa
     2701 aatcagtatt tttatagcag ataaattgac tgtcattctt cttaaaaatc atctattagt
     2761 tattgttagc atattgaaag aaattatagt aatctattga ataaatgaat attgcctata
     2821 atcatataaa ctgctatagt ttaaaataaa gcaggacgtt aaattttata gtaatctaaa
     2881 aatttaagag ggggatttta tgaaaataaa atttgttatt atgccattgg tgatattttt
     2941 aatggtatta tttgtggggt gtcaaagtac aaaagataca gaagttaaag caaaagatac
     3001 agaaattaaa atattaggga caggtgattt acattcaatt ttgacagact ctatggtttc
     3061 gtatgtaaat gaggaaaggg aaaagaataa aaatctgctt atggtagatg cgggagattt
     3121 ctatggtaca caaagtagag aaatgtggga atggtcttct ggaaaaaagt taattaatat
     3181 taaaagaaat ggtagagcag agtatgatga cataattaag agtagtaaag atgaagtacc
     3241 tatagttaaa gatatggcaa agttgaaata tgatgctgta gttttgggag ataatgaatt
     3301 tgtttcaaat gataagcaaa gtcttgataa actggtttct gattttaaaa ataataatat
     3361 gccattggta tcagcaaata tatatgaaca atctggagaa aattatgtac aaccatatgt
     3421 aatgaaaaat attaagacag atgagggcaa tgtaaaagtt ggaatactag gtcttactat
     3481 aaaagaagta ggggaaaccc ttggtcttga ggattttgaa aaggataaaa aagctagaga
     3541 gcttggagaa caagctgatt acaaaggaaa attatatgca aatgatttag tagaagatgc
     3601 aaaaaaatgg ataaaagtta tggaaaaaga aagtccagac ataatagttg cagttgtaca
     3661 ctcaggggaa gaacctaaaa cagatagaaa tccaggaaat agaataaaag agttagcaac
     3721 tacagtggat ggaatagatg caattgtagc tggtcatact catgaaaaaa tagatgaaca
     3781 caaatataaa aataaatctg gagatgaagt aattgttaca caaccaggtt ggcatggaga
     3841 tagagtatca gagattaatt tcaaactaaa taaagagaat ggaaagtggg acataaagga
     3901 aaagtctagt aaattaaaaa taattgataa agaagtaagt atagttgcta ctgcagattt
     3961 acattcacat ttctctgata aattaacagt tgaccttgtt aatgaacgaa gtaacccaat
     4021 tgaacctgtt gtagtagatg caggcgactt cttagaccct caaacagatg aaatgactca
     4081 atggtataaa gagtggaaaa gtataagaga taataatagt gataaaacga ttagtagatg
     4141 cccaatggtc atggatatga atcagggaat gtatgatgca gtagtacttg gaaatcatga
     4201 atttgtatct gaaaaagatg aattttggtc agatgaacgc cttttagatg ctgttataga
     4261 ggattttgaa caggtggcaa tttctgtgtt atcggcaaat atatataggc aatctggtaa
     4321 aaattatgtt aaaccatata ttataaaaga tgtggagacg agtgaaggta atgtaaaagt
     4381 aggaatattg ggacttacta taaaagaagt aggtaaaggt cttaaaaatg taaacttaca
     4441 agagcaattt caatataagg ataaattgta tgcaaatgat ttagtggaag atgcaaagaa
     4501 atgggtaaaa gttatgaaaa agaaaaaacc agatataata gttgcagttg tacattcagg
     4561 agaagaacca aaaaatccaa aacatccagg aaatagaata aaagaactag caactacagt
     4621 agatggtatt gatgcaattg ttgctagtca tactcatgaa aaaatagatg agcatgaata
     4681 taaaaataag tctggagaaa aagttatagt gacacaacca ggtgagcatg gtaaatatta
     4741 ttctaaaatt acctttaaag taaataaaga aaagggttcg tggactatta atgataaatt
     4801 cagtaaaaca attgaggttg aataacttta taaaatttat agataaagta aattatctga
     4861 tattggcatg atatataaga taaagtttct aatattagta taatgcataa tgtgaaatat
     4921 tttaataata agagaataaa caagacaaat aaaaatattt taacatgtaa gatatagtat
     4981 gaactattat actaatgctt actttataat ttgaacatgt tagaataagt cttatttgaa
     5041 aattttagtg tactagagta agtattattt tactagtaaa aaatattgag aactatatgt
     5101 agatttgctt aaaaaggaat ttacatatag ttcttttcgt ataataaata gtacaatctt
     5161 atatggtaaa gataaagtgt gatattaaat tttattatca tccaaaatct aaggaggagt
     5221 ctcttatgaa aataaaattt attatagtag catcaataat atttttaata gtattacttg
     5281 tggggtgtca aagtactaaa gacacagaaa tcaatgtact cgccacaagt gatttacatt
     5341 caattattcc agataattta atttcctatg tagaagagga gagaaaatat gatgagaatc
     5401 tacttatggt agatgcagga gatttttttg acatgcaaag tggtgagatg aataagtggt
     5461 ttactggtca aaaattagta agatttaaag atgggatacc agagtacaaa aaaatagctg
     5521 aaccacgtga aggagaagtt ccattggcta aaaaaatggc aaagctgaag tatgatgcag
     5581 ttacatttgg gaatcatgaa tttgtatcta atgacaagca gagccttgat aaattggttt
     5641 ctgattttaa aaataacaat ataccattag tatcagcaaa cgtatatgaa caatctggag
     5701 aaaactacgt aaagccatat gtaatgaaaa atataaatac tgacaaggga actgtaaagg
     5761 ttggtatact tggtctgact ataaaagaag taggggaacg ttcaaggttt aaaagttttg
     5821 aacaagataa aaaggctaga gaacttgggg aacaacctca atacaaaggg aaattatatg
     5881 caaatgattt agtagaagat gcaaataagt gggtaaatgt tatggaaaaa aaagaaaagc
     5941 cagatataat agttgccatt gtacattcag gtgaagagcc aaaaaatcct aaaaatccag
     6001 gaaatagaat aaaagaacta gcaacaactg tagagggaat agatgctatt gtagcaggtc
     6061 atacacatga aaaaatagaa cagcatacat ataaaaataa ttctggtgaa gaagtaatag
     6121 taacacagcc tggagctcat ggtaatagta tatcaaagat taattttaag ttggataaga
     6181 agaatgataa gtggtttata aaagacaaat atagtgaatt aaaggttttt ggaaaggaag
     6241 taaatataat tacaacttct ggtctgaatc caaaattttc agatgaaatg gcagttaatt
     6301 tgtttaatga aagagataga gatgttcaac ctatctttat agatactgga gattttttaa
     6361 atactaatac aaaagaaatg actaagtggg ctaaagagtg gcaatacaat gaaaataaag
     6421 gcatctataa aaaaataaat gaatggccaa ttgtatatct tggttatgat gctgtagtac
     6481 ttggtagcca tgaatttaca gaggataaag agacttttga ggaaaaaaaa tctacattgg
     6541 attatattat agaaaacttt gaagaaatga agataccagt attatcagct aatatatatg
     6601 atgaatctgg agaaaattat gtaaaacctt atataattca taatgtagaa actagggaag
     6661 gaaatataaa ggttggagta ttaggtctta ctactactga taaggatgaa gaagacttaa
     6721 gtaactcaag cttaagcaaa gactcaaaga cttcgaaaat tcctgaagaa acaggaaagt
     6781 tatatactaa taatctagta aaagatgcaa gcgaatgggt aaaagttatg caaaaggaaa
     6841 gtcctgatgt gattgttgta gttgtacatt cagataataa tagtactcta aaaaatccaa
     6901 gtagtgaagt caaaaaactt gcaatgtcag tagatggaat agatgctatt gttgtaggtc
     6961 atacgaaaaa taaggtagaa gaacatattt acaaaaataa gtctggggat gaggttatag
     7021 taacacaatc tggagaagat tgttattcaa aaataagtct tgaactaaga aaagaaaatg
     7081 gcaagtggaa tatcataaac aaatatagta aagcaataaa aatgaagtga atttattgat
     7141 atataaacca ttattaacac tgatttttat aatataataa atactgattc tacaatataa
     7201 ttaacactga tttttataat ataataaata ctgattctac aatataatta acactgattt
     7261 ttataatata ataaatactg attctataat ataattaaca ctacttttta taatgtc
//
LOCUS       DAEHWM010000143         7262 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.146, whole genome shotgun sequence.
ACCESSION   DAEHWM010000143 DAEHWM010000000
VERSION     DAEHWM010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7262)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7262)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7262
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.146"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            145..1650
                     /locus_tag="KNP36_003497"
     CDS             145..1650
                     /locus_tag="KNP36_003497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003374392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HBF0875326.1"
                     /translation="MKVGFDHKKYLEEQSKYILERVNNFDKLYLEFGGKLMGDLHAKR
                     VLPGFDENAKIKVLQHMKEKVEVVICVYAGDIERNKIRGDFGITYDMEVLRLIDDLRG
                     YELDVNSVVITRFEGQPATTVFINKLERRGIKVYKHYPTKGYPSDVETIVSDEGYGAN
                     EYIETTKPIVVVTAPGPNSGKLGTCLSQLYHENKRGNVVGYSKFETFPVWNVPVKHPL
                     NIAYEAATVDLKDVNMIDSFHLETYGEMSVNYNRDLELFPVLKKIIEKITGKESIFQS
                     PTDMGVNRVGFGIIDDEVIRKASIEEIIRRYFKTACEYKKGQVDKGAYDRMKMIMEEL
                     NLKPEDRNVVLPARNYSNKLKESADKNDTCPVVALELEDGTILTGKGSDLMNGTAAVV
                     LNAIKHLANISDDMHLISPVILEPIINLKTKTLASRNVSLSCQEVLTALSICAVTNPT
                     AQFAMEKLALLKGCQAHSTTILNRDDEQTFRKLGIDVTCDPEYPSQNLYYS"
     gene            2040..3137
                     /gene="dinB"
                     /locus_tag="KNP36_003498"
     CDS             2040..3137
                     /gene="dinB"
                     /locus_tag="KNP36_003498"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HBF0875327.1"
                     /translation="MKHYRKIIHIDMDAFYASIEQRDNKKLKGRPVIVGGNPQSRGVV
                     ATCSYEARKFGIHSAMPSAVAYNRCPYAVFVRPRFDVYKSVSEQIRDIFYRYTDLVEP
                     LSLDEAYLDVTKNKKNIDSSIEIAKQIKKDIFREVGLTSSAGVSYNKFLAKIASDLRK
                     PNGLTVITEENAQDFLDKLPVNKFFGVGKVTSNTLKNLGIKTGYDLRCLNLFELENIF
                     KKRGYELYKFARGIDDRPVEPNRVRKSVGAETTLSHNLDIDEEETRNILDELCEEVCH
                     RLKNSEKFGKTLTLKIKYEDFTKITRSLSLEHYIDEYNDIRSGVDNLLRNVEVNGKQI
                     RLLGVTISNLSDKKETYKDITLFEYMDSIQM"
     gene            3400..4536
                     /locus_tag="KNP36_003499"
     CDS             3400..4536
                     /locus_tag="KNP36_003499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875328.1"
                     /translation="MIEIRNVTKKIGNNVILDDISLVVETGTLVVLIGSSGCGKTTTL
                     KLINKLIKPTSGEIYINGKPISQENEIELRRKIGYVIQNTGLFPHLTIKENIELIPRL
                     KKEKSVEEIEKRTLQLLEMVGLDSDEFLNKYPSELSGGQQQRIGVARAIATDAEIILM
                     DEPFSALDPITRTSLQEQLFSLQDELKKTIIFVTHDMDEALKIADKICIMKDGRIAQY
                     DTPENILRKPANDFVKDFIGEDRVWDNPEYIKARDIMIKNPIAVNSTRTVTQGIEIMR
                     TSKVDSLLIIDRAKTLKGIVTVKDMKDIDDKSILLADIMSSEPLHVNEGDNLVEILNV
                     MNRNSVGYIPVISDENKLVGLITRSSLLSVLSEQFLEMEVSVLG"
     gene            4529..6076
                     /locus_tag="KNP36_003500"
     CDS             4529..6076
                     /locus_tag="KNP36_003500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HBF0875329.1"
                     /translation="MANFFNFILLQKDKIIELLIQHMSLTVTSILIAIIVGVPLGIII
                     SRISSLRKFVLGFVNLVQAVPSMALLGLLVPILGIGSKPAIFMVVVYSLLPIVKNTYI
                     GITSIDPVVLESAKGIGLTRNQTLFKIQFPLALPIIMGGVRISAVTAVGLMTLAAFIG
                     AGGLGYLVFSGVQTVNNNMILAGAIPSCIIALLVDYLFSKIEVAVTPKGLNPKAPKKN
                     YIALKVISVVVVVSMLFVVFSSSFSSKKDTITIGSKDYTEQLILGNVYAELVEKNTNL
                     KVKKNLNLGGSSVAFNAIKSGELDMYVDYTGTLLVNVMKHAPIKDADEAYNVVKDTME
                     KENQLTLLDPLGFNNTYTLAMMPETAEKYGINTISDLTKYGKEFTFSPTLEFENREDG
                     LVGLSRDYGLKFKDVKAMNGSLRYTALDNNESQVIDAFLTDGLIKKFNLKILEDDKNF
                     FVPYYAAPLVREDTLKKYPELEKVMNMLSGKINEETMRELNYQVDELGKSPEEVAHSF
                     LVKEGLV"
     gene            6411..>7262
                     /locus_tag="KNP36_003501"
     CDS             6411..>7262
                     /locus_tag="KNP36_003501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HBF0875330.1"
                     /translation="MDNYKKVKQVLWIILFANFAVALLKIIIGNQIKSYSMTADGFHS
                     LSDGASNIVGLIGIFFASKPKDKNHPYGHKKFEIITSLFISGMLFVIAIKIILSAVLR
                     IANPVVPAITIESLIALIITLFINIFVCMYEYRIGTKLNSYVLISDSLHTRSDIFVSL
                     GVLVTLVGVKLGFPVIIESIVPIIISAFIIYSAYGIFRPSIGILVDRVAVDEDYIKEI
                     VFEFNEVRDVHNIRSRGSKSSIYIDMHVMVDPFISVEQSHDLTHKIEKQIQEEINENA
                     QVIVHIEP"
BASE COUNT         2762 a          794 c         1294 g         2412 t
ORIGIN      
        1 actatcttga aaaaaattaa tcttaattgt ataatattac tttgagtgaa aaagtattaa
       61 cattttttta taagatgttt tactaaaaaa atatatataa atatactgtt atcaacaaga
      121 aatttaattt agtgaggtgt taagatgaaa gtaggatttg accacaaaaa atatttagaa
      181 gagcagtcta aatatatctt agaaagagta aataattttg acaaacttta tttagagttt
      241 ggaggaaaat tgatgggaga ccttcatgca aaaagagtac ttccaggatt tgatgaaaat
      301 gcaaagataa aagtattaca acatatgaaa gaaaaagttg aagttgtaat ttgtgtctat
      361 gcaggagata tagaaagaaa caaaataaga ggagactttg gtatcactta tgatatggaa
      421 gttttaagat taatagatga tttaagaggt tatgaactag atgtaaatag tgtagtaatt
      481 actagatttg aaggacaacc tgctacaact gtatttataa ataaattaga acgtagagga
      541 attaaagttt ataagcatta tccaacaaag ggatatccgt cagatgttga gactatagtt
      601 agtgatgagg gatatggagc aaatgaatat atagaaacta caaagccaat agtagtagtc
      661 acagcaccag gacctaatag tggaaaactt ggtacttgtc taagtcagtt gtatcatgaa
      721 aataaaagag gtaatgtagt tggatattct aagtttgaga cattcccagt ttggaatgta
      781 cctgtaaaac atcctttgaa tatagcttat gaagcagcta cagttgattt aaaagatgtg
      841 aatatgatag attcattcca ccttgaaacg tatggtgaaa tgtcagtaaa ctacaataga
      901 gatttggaat tatttccagt gcttaaaaaa ataatagaaa agataactgg aaaagaatca
      961 attttccaat ctccaactga tatgggtgtt aatagagttg gctttggaat aatagatgat
     1021 gaagtaataa gaaaagcttc tatagaagaa ataataagaa gatactttaa aactgcctgt
     1081 gagtataaaa agggacaagt tgataaaggt gcttatgata gaatgaaaat gattatggaa
     1141 gagcttaact taaagccaga agatagaaat gttgtattac ctgctagaaa ctacagtaat
     1201 aaattgaaag aaagtgccga caagaatgat acttgtcctg tagttgcatt agaattagaa
     1261 gatggtacaa tattaactgg taagggttct gatttaatga atggaactgc agcagtagta
     1321 ttaaatgcca ttaaacattt agccaatata tctgatgata tgcacttaat atcacctgta
     1381 atattagaac ctatcataaa cttaaaaaca aagactttag ctagtagaaa tgtttcactt
     1441 agttgccaag aggtgttaac tgcacttagt atttgtgctg taactaatcc aactgcacaa
     1501 tttgctatgg aaaagttagc attattaaaa gggtgtcaag ctcattctac tactatatta
     1561 aatagagatg atgaacaaac atttagaaaa cttggtatag atgtaacttg tgacccagaa
     1621 tatccttcac aaaatcttta ctatagttaa aattatataa aaaaatatgg gctgttttaa
     1681 agtaatagtt tgagcagtcc attacaatta taataaaatc agtaggctgt cttgtataag
     1741 acagtctttt gtttttaaaa catcccataa attaaatata tatactgtta tccataagga
     1801 attttaaatt tagttccttg gaatacctat tgtaaagctt ttatatagtt tttgcaagtg
     1861 tttttaagga ttttttataa attatattga agttaatgga ttatagatgg ttttatttat
     1921 ggaaaatatg aatatataaa gaaaataatg aaaaaatacc aaaaagaaac ataagtttgg
     1981 tataattaaa aagtaatata aataaaatta atctatttat actttaaaag gtgataataa
     2041 tgaaacatta tagaaaaata attcatatag atatggacgc tttttatgca tctatagaac
     2101 aaagagataa taaaaaatta aaaggaagac ctgttattgt cggtggaaat ccacaaagcc
     2161 gaggtgtggt tgcaacctgt tcttatgaag ctagaaaatt tggtatccat tcagctatgc
     2221 catcagctgt agcttacaat aggtgtccat atgcagtttt tgtaagacct agatttgatg
     2281 tttataagag tgtgtcagag caaataagag atatatttta tagatacaca gatttagttg
     2341 aaccattatc tttagatgaa gcttacttag atgtaacaaa aaataaaaaa aatattgatt
     2401 catcaattga gatagcaaag caaataaaaa aagatatatt tagagaagtt ggtcttactt
     2461 cttcagctgg tgtgtcatac aataagtttc ttgctaagat tgcatcagac ttaagaaagc
     2521 caaatgggtt aactgtaata accgaagaaa atgcccagga ctttttagat aaattacctg
     2581 tgaataaatt ttttggtgtt ggaaaagtta cttcaaatac tcttaaaaat ttaggtataa
     2641 aaactggata tgatttaagg tgtttaaatt tatttgaact tgaaaatata ttcaaaaaaa
     2701 gaggttatga attatataaa tttgctagag gaatagacga tagaccagtg gaaccaaata
     2761 gggttagaaa atctgttggg gctgagacta cattaagtca taatttggat attgatgaag
     2821 aagaaacacg caacattctt gatgaacttt gtgaagaagt atgtcataga ttaaaaaact
     2881 ctgagaagtt tggaaaaaca ttaacattaa aaattaaata tgaggacttt acaaagataa
     2941 ctagaagcct tagtttagaa cactatattg acgaatataa tgatataaga agtggtgtag
     3001 ataatttgtt gagaaatgtt gaggttaatg gaaaacaaat taggctattg ggagttacaa
     3061 tatcaaacct aagtgataaa aaagaaactt ataaagatat tacattattt gaatacatgg
     3121 atagtatcca aatgtgagtt ttgtttaaat gaaataacac tagctttaat actatataat
     3181 tgaggctagt gttattttat gaatattttt atattttttg ttttttgaca ttgtatatta
     3241 tatactatat ataaatactt tatatttgta gcaatattca gacaaatagt gacctaaaaa
     3301 tcgtactttg tttacataaa taaaatagta tgatataatt ataaaaacaa cttataatat
     3361 tggagaaggt tgcttgttcg aaaaagggga tgataaatta tgatagagat aagaaatgta
     3421 acaaaaaaaa taggaaataa tgttatatta gatgatattt ctctagttgt agaaacaggt
     3481 acattggtag ttttgattgg ttcaagtggt tgtggaaaga ctactacttt gaagcttata
     3541 aacaaattaa taaaacctac atctggtgag atatatatta atggcaaacc aatttctcag
     3601 gaaaatgaaa tagagcttag aagaaaaata ggatatgtta tacagaacac aggcctattc
     3661 cctcatctta caataaaaga aaatatagag ctaattccac gcctaaaaaa ggaaaaatcc
     3721 gttgaagaaa ttgaaaaaag aacgttgcaa ctacttgaga tggtaggact tgatagtgat
     3781 gaatttttga ataagtatcc ttcagaactt agtggtggac agcaacaaag aatcggtgtt
     3841 gcaagagcca ttgctactga tgctgaaata atattgatgg atgagccttt tagtgcttta
     3901 gacccaataa cgagaacatc tttacaagaa caattatttt ctcttcaaga tgaattgaaa
     3961 aaaactataa tatttgtaac gcatgatatg gatgaggctt taaagatagc tgataaaatt
     4021 tgtattatga aggatggaag aatagcacaa tatgatactc ccgaaaatat acttagaaag
     4081 cctgcaaatg actttgtaaa agattttatc ggagaagata gagtttggga taatccagaa
     4141 tatataaaag caagagatat tatgataaaa aatcctattg ctgttaattc tactagaact
     4201 gtaactcaag gaatagaaat tatgagaacg agtaaggttg atagcttact aattatagat
     4261 agagcaaaaa cattaaaagg tattgttact gtaaaagata tgaaagatat tgatgataag
     4321 tcaatattac ttgctgatat tatgtcaagt gagcctttgc atgtaaatga aggggataat
     4381 ttagtagaaa tactaaatgt aatgaatcgt aattcggttg gatatattcc ggttatttct
     4441 gatgaaaata aactggtagg gcttattact agaagtagtt tactttctgt tttaagtgaa
     4501 caattcttag aaatggaggt gagtgttctt ggctaatttt tttaacttta tactattaca
     4561 aaaagataag attatagagc ttttaataca acatatgagt ctaactgtta catctatttt
     4621 aatagctata atagttggtg ttcctcttgg aataattatt tcaagaatct catctcttag
     4681 aaagtttgta cttggatttg taaacttagt ccaagcagtt ccgtctatgg cacttttggg
     4741 tcttcttgta cctatacttg gtataggaag taaaccagcc atatttatgg tagtggttta
     4801 ttcattacta ccaattgtaa aaaatacgta tataggtata acaagtattg acccagtagt
     4861 attagaatca gctaaaggta ttggtcttac aagaaatcag acattattta aaatacaatt
     4921 ccctttagca cttcctataa taatgggtgg agttagaata tctgcagtta cagctgttgg
     4981 tttgatgact cttgcagcat ttataggtgc tggtggttta ggatatttag tattttcagg
     5041 ggttcaaact gtaaataata atatgatttt agcaggggca atcccatcat gtataattgc
     5101 actgttagtt gattatttat ttagtaaaat tgaagttgca gttactccaa aaggattaaa
     5161 tccaaaagca cctaagaaga attatatagc acttaaagta atatctgtag tggttgttgt
     5221 ttcaatgttg ttcgttgttt ttagttctag tttttcaagt aaaaaagata caataactat
     5281 tggttctaaa gattatacag aacaacttat acttggtaat gtttatgctg aattagtaga
     5341 aaaaaatacg aatcttaaag ttaagaagaa tttaaatcta ggtggttcat ctgttgcgtt
     5401 taatgcaatt aaatctggtg agttagacat gtatgttgac tatacaggta cacttttggt
     5461 aaatgtaatg aaacatgctc cgattaaaga tgctgatgaa gcatataatg ttgtaaaaga
     5521 tactatggaa aaagaaaatc agttaacttt acttgaccct cttggattta ataatactta
     5581 cacattagct atgatgcctg aaactgctga aaagtatgga ataaatacta tttctgattt
     5641 gactaaatat ggtaaagaat ttacattctc accaactttg gagtttgaaa atagagaaga
     5701 tggtcttgta gggctttcta gagattatgg tttaaaattc aaagatgtaa aagcaatgaa
     5761 tggaagttta agatatacag ctttagataa taatgaatct caggttatag atgcattttt
     5821 aactgatggt cttattaaaa agtttaatct taagatatta gaggacgata aaaatttctt
     5881 tgtaccatat tatgcagcac cattagtaag agaagatact ttgaagaaat atcctgagtt
     5941 agaaaaagtt atgaatatgc tttcaggaaa aataaatgaa gaaactatga gagaacttaa
     6001 ctatcaagtg gatgaacttg gtaaatcacc agaagaagtt gctcattcat tcttagttaa
     6061 agaaggctta gtataaaaaa ttaatagttt atatcaaaaa atttaagaga gtgtctcaaa
     6121 atgaactttt tagttcatga ggcactcttt tttatatgaa atcaaatata ttttatcatt
     6181 tcaacaataa aaaagaagat tatctttatt ttgagacagt ctcttatttt tatgtatacc
     6241 aaaaccatac ctacgatttt tatttataat taagtttcaa atagaatgaa caagtacaac
     6301 caattttgaa tataaatata gtaaatgtgc ttatatacga ttttattgtc tggttgattg
     6361 atattgatag atagctttct ttattgaatc gaagggaggg ggaatttgtt atggataact
     6421 ataagaaagt gaagcaagta ttgtggataa ttttatttgc taattttgca gtagcattat
     6481 taaaaatcat tattggtaat caaataaaaa gctatagtat gacagcagac ggatttcatt
     6541 ctttgtcaga tggagcatct aatatagtgg ggcttatagg tattttcttt gcatctaaac
     6601 caaaagataa aaatcatcct tatggacata aaaagtttga aattataacc agtttattta
     6661 taagtggtat gttgtttgtt atagcaatta agataattct tagtgcagtg ttaagaatag
     6721 ctaatccagt tgtacctgct ataactatag aaagtttaat tgctttaatt attacacttt
     6781 ttataaatat ttttgtatgc atgtatgaat atagaattgg gactaaacta aatagttatg
     6841 ttttgatttc ggattcattg catacaagaa gtgatatatt tgtgtctcta ggtgtattgg
     6901 ttactttagt tggtgttaag ttaggatttc cagtaataat agaatctata gttcctatta
     6961 ttatttctgc attcataatt tattcggctt atggaatatt taggccatct attggaattt
     7021 tggtcgatag agtggctgta gatgaggatt atataaaaga aattgtgttt gaatttaatg
     7081 aggtaaggga tgttcacaat atcagaagta gaggtagcaa aagttctatt tatattgaca
     7141 tgcatgtaat ggtagaccca tttataagcg tagagcaatc tcatgattta acacataaaa
     7201 ttgagaaaca aatacaagaa gaaattaatg aaaatgctca agtaatagtc catattgaac
     7261 ct
//
LOCUS       DAEHWM010000144         7123 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.147, whole genome shotgun sequence.
ACCESSION   DAEHWM010000144 DAEHWM010000000
VERSION     DAEHWM010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 7123)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7123)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7123
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.147"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            41..901
                     /locus_tag="KNP36_003502"
     CDS             41..901
                     /locus_tag="KNP36_003502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HBF0875331.1"
                     /translation="MLLKKDRITFSEILILIVGCILMAISLNLFFNPHAIAAGGITGL
                     GVVLNSLFGVELWIVNLLLNVPLFIFAYKILSKKDCFKTVLGIIFLTIALKLTANMAT
                     LDITNDMYLAIISGSILMGVGQGLIFRINGSTGGTDLMALLLNKYFPTFSIPVLMGIV
                     DCVVVVLSGIVNRQVEIALYSTVALYILVKVSDLLIEGFNYSKSFTIISDLSKDISKK
                     IMEDLDRGATILKGEGAYTGENKNVLLVVVEKKEVVELKKLVKNVDPNAFIIITDIHE
                     ALGNGFKKIE"
     gene            1357..1923
                     /locus_tag="KNP36_003503"
     CDS             1357..1923
                     /locus_tag="KNP36_003503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBF0875332.1"
                     /translation="MSVSLQKGQRVSLVKDNNPVKNLVVGLGWDMNKLGKKNYDLDAF
                     AIALTNQDKMNVRGDLVYFGNLKHPSKAIIHTGDNLTGKGEGDDEQIIVNLEDIPEYV
                     HKIVFGVSIYKAKKRDQDFGQINNSFIRLIDSNSKQELFKYNLQEDFSGKVTVLAGEI
                     YRRNEEWKFNALGIGQNEELRELINTYK"
     gene            1963..2544
                     /locus_tag="KNP36_003504"
     CDS             1963..2544
                     /locus_tag="KNP36_003504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TerD family protein"
                     /protein_id="HBF0875333.1"
                     /translation="MGITLAKGQKVSLTKSNPGLKKVIVGLGWDINKYDGGFDFDLDA
                     SAFLTGTDGKVTNDGDFIFYNNLKHASGAVEYMGDNRTGVGDGDDEQINVDLSKIPQN
                     IAKISFSVTINEAITRRQNFGQVENSYIRIYNEETNEELIKYELGEDFSIETAIVVAE
                     LYRHNGEWKFNALGSGFEDGLAGLCKNFGVNIG"
     gene            complement(2601..3518)
                     /locus_tag="KNP36_003505"
     CDS             complement(2601..3518)
                     /locus_tag="KNP36_003505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HBF0875334.1"
                     /translation="MTIRSLEIFVKVAECGKMSEVARNMYITQSSVSQAISEIEKEYG
                     VKLFDRISKKLYLTEAGKKLLGYGRHLLAVNEEMNDCMKHCAKNIRIRVGATVTVGTC
                     VISPIMLELYKVNPLIEPEVFVEDTRLIAKKLLNSELDIAIVEGKIKHPDIVTKSIIN
                     DNLVLICSHKHEFYKRDSIKVSELSNQPLIMRELGSGTRAQLEKQLKELKIPMNIRWS
                     CYNSEAILRAVVDNFGIAVISELLIEDYLKKHLLWACDIEGINLHRTFDIAYHRSKFF
                     TENISAFFDISVEYGKKQARKKSRSVNSL"
     gene            3648..5279
                     /locus_tag="KNP36_003506"
     CDS             3648..5279
                     /locus_tag="KNP36_003506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBF0875335.1"
                     /translation="MKVLIIGGVAAGTKTAAKIKREMGDNCSVTILNKGDDISYAGCG
                     LPYYVGKIIEDKSSLIVNTPESFSKLTGAEVRCGVEVTSIDRNAKQVTLKTLSTGEKE
                     NLSYDKLVIATGADPIKPPIPGIDLPGVFFMRTPNDAIKLRDSIENGIKRAVVIGGGF
                     IGLEIAENLSAMGIRVSVVDMAEHVMPGFDTDFAEYVENHMADKGIMIFTGDQVVGIE
                     GENKVEKLRTKNRAIKTDLVVMSVGIRPNTGFLKDTGLEFAPNNTIIADEYMLTNDKD
                     IYVVGDCAFVKNSLTNKPTWSPMGSSANHEGRICAQNISGKSKTYNGVLGTTVVKLPE
                     LNAGKTGLSKEIAEKEGYNVCSVTIATDDKAHYYPGASNFIIRMVAEKNTRKLLGVQV
                     MGPGAVDKIVDIAATAITLGADLYSLESMDLAYAPPFSTAIHPFVVAVNVLQNKLNGE
                     LDSVLLDEIEDFDSWTKLDVSKAPSIPSLRYIPVGEINGEIEGLAKDEKILLICAKGK
                     NSYMAQNRLRRFGYTNTKVLEGGILFYPNLKVMEE"
     gene            5282..6229
                     /locus_tag="KNP36_003507"
     CDS             5282..6229
                     /locus_tag="KNP36_003507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013378669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="HBF0875336.1"
                     /translation="MSNVTAEQKKEVKGRGFLPSRDGEHFAARIITVNGVINASQAKK
                     IAEAAEKFGNGQLAFTTRLTVELPGVKFEDIEALSEFIASENLITGGTGSRVRPVVAC
                     KGTVCVHGLANTQALAAEIHEEFYKNWYDVKLPHKFKIGVGGCPNNCIKPDLNDLGIV
                     GQRVPDYDSELCVGCKKCAVVEVCPVKAAKLTDKGKLEIDSNLCNNCGKCIESCNFDS
                     IEEKESGYKVYIGGKWGKSVRPGTQIDRLFSKEELMTLIEKAILLFREQGNTGERFGI
                     TIDRIGADKFIEMLLSDEVLERKEEILEALLHLTGGAVC"
     gene            complement(6514..6777)
                     /locus_tag="KNP36_003508"
     CDS             complement(6514..6777)
                     /locus_tag="KNP36_003508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1883 domain-containing protein"
                     /protein_id="HBF0875337.1"
                     /translation="MEYSYSKMNLKKGDIVEVNLEKQANVILLDHINYVKFKNQRNYD
                     YYGGFAKKNPCRMRVPNTGTWYLVVNQDGNSGIVNFSINTIQN"
     gene            complement(6876..7121)
                     /locus_tag="KNP36_003509"
     CDS             complement(6876..7121)
                     /locus_tag="KNP36_003509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875338.1"
                     /translation="MFIDEELEGYILTCKISEDFKNIPEYSDEEFYVTVYKDESSDSG
                     YYALLENKEERVVWDGEVVANNIFNNLWIVVNKVKTG"
BASE COUNT         2585 a          931 c         1146 g         2461 t
ORIGIN      
        1 aaactatata atatatatta taatctatat ataaggagtg atgttattga aaaaagatag
       61 aataactttt tcagaaattt taatattaat tgtaggctgt atattaatgg ccatttctct
      121 taacttattt tttaatccac atgcaatcgc tgctggtggt ataacaggac ttggagttgt
      181 tttaaattca ttattcggtg tagaactttg gattgtcaat ttacttttaa atgttccatt
      241 attcatattt gcttacaaaa tactttcaaa aaaagattgt tttaaaacgg ttttaggaat
      301 aatttttctt accatagcac ttaagcttac tgcaaatatg gctacattag atataacaaa
      361 tgatatgtat cttgcaatta tatctggttc tattttaatg ggagttggtc aaggacttat
      421 ttttagaata aatggctcta caggtggaac tgatttaatg gcactcctac taaataaata
      481 ttttcctaca tttagtatac ctgttttaat gggtattgta gactgcgttg tagttgtttt
      541 atcaggtata gtaaatagac aggttgaaat tgcactttat tcaactgtgg ctttatacat
      601 tttagtaaaa gttagtgact tgcttattga aggatttaat tattccaaat cattcactat
      661 tatatctgac ctttcaaaag atataagtaa aaaaataatg gaagatttag atagaggtgc
      721 aactattcta aaaggagaag gtgcatatac tggagaaaat aaaaatgtac ttttagtagt
      781 agttgaaaag aaagaagttg tcgaattgaa aaaattagta aaaaatgtcg accctaatgc
      841 ttttattata attacagata tacatgaagc tttaggtaat ggatttaaaa aaatagaata
      901 actaacaaat aaatagcaag tataattaac atatacaaat tcaacttttt atatgttata
      961 ttatacttgc tatttatata ttatacttgc tatttatata ttataattgt tgtttttaag
     1021 ataaaaatta aatgtatcaa ttattgtttt atacaagtat ttccaaatcc gttctcattt
     1081 agatagtatg cttagaaatt ttagaattat tgagtctaac tttattactt actttacttt
     1141 ataacaatca aatacaaatt taaatattat aaaactacaa aataatttaa agcatataat
     1201 gtcaatatgt ttaaattata aaatattcat gtagttatat aataaataat ttataaatat
     1261 agccaactta gcctaaatac gtatataata tagctaatat ggttcttata cttgatacca
     1321 tcaataaaac taaaaatata aaaaggagaa cttaaaatga gtgttagttt acaaaaagga
     1381 caaagagtta gcttagtaaa agataataat cctgtaaaaa atctagtagt aggcttagga
     1441 tgggatatga ataaattggg taaaaaaaat tatgacctag atgcatttgc aatagcattg
     1501 actaaccaag ataaaatgaa tgttagaggt gacttggttt attttggaaa tcttaaacac
     1561 ccttctaaag ctattataca cactggagat aacttaactg gaaaaggtga aggtgatgat
     1621 gaacaaataa ttgttaattt agaagacata cctgaatatg tacataaaat agtttttgga
     1681 gtttctatat acaaagctaa aaaaagagac caggattttg gtcaaataaa caactctttt
     1741 ataagattaa ttgattcaaa ttccaagcaa gaattattta aatataatct tcaagaagac
     1801 ttttctggta aagtaacagt tttggcagga gaaatttatc gtagaaatga agaatggaaa
     1861 tttaatgctt taggaattgg tcaaaatgaa gagcttcgtg aattaattaa tacatataag
     1921 taataattac aataaaaaat ttataatgag gagttggttt aaatgggtat aactttagca
     1981 aaaggacaaa aagtaagttt aacaaaaagt aaccctggtc taaaaaaagt aatagtagga
     2041 ctaggatggg atattaataa atatgatggt ggctttgatt tcgatttaga tgcctctgca
     2101 tttttaactg gaactgatgg aaaagtaacg aatgatggag actttatatt ctataataat
     2161 ttaaaacacg cttctggagc tgttgaatat atgggtgata atagaacagg tgttggtgat
     2221 ggtgatgatg aacaaataaa tgtagactta tctaaaatac ctcaaaatat tgctaaaata
     2281 tcatttagtg ttactataaa tgaagcaatt acaagaagac aaaatttcgg acaagttgaa
     2341 aattcatata taagaatata taatgaagaa actaatgagg aacttattaa atatgaattg
     2401 ggtgaagatt ttagcataga aacagcaata gttgtggcag aactatatag acataatgga
     2461 gagtggaaat ttaatgcttt aggttctgga tttgaggatg gacttgcagg attgtgtaaa
     2521 aattttggcg ttaatatagg ctaatatatc taaataaaaa taagagtata ttgatatact
     2581 cttattttta tttagatata ttataaactg tttacacttc tactcttctt tctcgcttgt
     2641 tttttcccat attctactga aatatcaaaa aatgctgaaa tattttctgt aaaaaacttg
     2701 cttctatgat atgcaatatc aaatgtccta tgtaaattaa taccttcaat atcacaagcc
     2761 cacaaaagat gcttttttaa ataatcctca ataagtaatt cggatataac tgcaatgcca
     2821 aaattatcta caactgctct taatatagct tcagagttat aacatgacca tctaatattc
     2881 attgggattt ttaattcttt taattgcttt tctaattgtg ctcttgtacc acttcccaat
     2941 tcacgcataa ttaatggttg atttgaaagt tctgaaactt ttatagagtc tcttttataa
     3001 aactcatgct tgtgtgaaca tataagtaca agattatcat taataatgct ttttgtaaca
     3061 atatctgggt gcttaatttt tccttctaca atcgcaatat ctaattcact attaagtaat
     3121 ttttttgcaa tcagtcttgt atcttctaca aatacttcag gttctataag aggatttacc
     3181 ttgtataatt ctaacattat tggacttatt acacatgtac caacagttac tgttgcccca
     3241 actcttatac ggatattttt tgcacaatgc ttcatacaat cattcatttc ttcatttaca
     3301 gctaaaagat gcctcccata tccaagaagt tttttccctg cctcagttaa atataatttt
     3361 tttgaaattc tatcaaatag cttaacacca tactcttttt ctatttctga aatagcttgg
     3421 ctaactgatg actgggtaat atacatattt cttgctactt cactcatttt accacattca
     3481 gcaaccttaa caaagatttc aagactacga attgtcatat tatcacaacc ttagcaaaca
     3541 ttagtaaatg cttatgattt tattaatatt ttagtatttt acaaatatat tgtcaagaag
     3601 tataatttta ttatagagtt ataaagtaga ttggagtgtg atatattgtg aaagtattaa
     3661 ttataggtgg agttgctgct ggaacaaaaa ctgctgcaaa aataaaacgt gaaatgggtg
     3721 ataattgctc tgttacaata ctaaataaag gtgatgatat ttcttatgca ggttgtggtc
     3781 ttccatatta cgttggtaag ataattgaag ataaatcatc tttaatcgta aatacacctg
     3841 aaagtttttc taaactaaca ggagcagaag ttcgttgtgg agttgaagtt acatctattg
     3901 atagaaatgc aaaacaagta actttgaaaa cgctttcaac aggagaaaaa gaaaatctaa
     3961 gctatgacaa acttgtaatt gctacagggg cagacccaat aaaaccacca atacctggaa
     4021 tagatttacc tggagtattc tttatgcgta ctccaaatga tgctataaaa ctaagagatt
     4081 ctattgaaaa cggtattaag agagctgttg ttattggtgg aggtttcatt ggtcttgaaa
     4141 ttgctgaaaa tctttctgca atgggtatac gtgtaagtgt tgttgatatg gctgaacatg
     4201 ttatgcctgg atttgatact gattttgctg aatacgttga aaatcatatg gctgataaag
     4261 gcataatgat ttttacaggt gaccaggttg taggtattga aggtgaaaat aaagttgaaa
     4321 aacttcgtac taaaaataga gctattaaaa cagatttagt ggttatgtca gttggaatcc
     4381 gtcctaacac aggttttcta aaagacacag gtttagaatt tgcccctaat aatacaatta
     4441 ttgcagatga atatatgctt acaaatgaca aagatatata tgtagttgga gactgtgctt
     4501 ttgtaaaaaa ttctttaaca aataaaccta catggtcacc tatggggtca tctgcaaatc
     4561 atgagggtag aatttgcgca caaaatatat ctggaaaatc taaaacttac aatggtgttc
     4621 ttggaacaac agtagtaaaa ttacctgagc tcaatgcagg aaaaacaggt ctaagtaaag
     4681 aaatagctga aaaagaaggt tataatgttt gctctgtaac catagctact gatgataaag
     4741 ctcattatta tccaggtgca tctaatttta ttataagaat ggttgctgaa aaaaatacta
     4801 gaaaattatt aggtgttcaa gttatgggac ctggagcggt tgataaaata gtagatatcg
     4861 ctgctactgc aataacttta ggcgctgacc tttattcatt agaaagtatg gaccttgcat
     4921 atgcaccacc tttttcaaca gctattcacc cttttgtagt ggcagtaaat gttttacaaa
     4981 ataaacttaa tggagaactt gatagtgttt tacttgacga aattgaggat tttgacagtt
     5041 ggactaaact tgatgtttca aaagctcctt ctattcctag tttacgttat attcctgttg
     5101 gtgaaattaa tggagaaatt gaaggtcttg ctaaggatga aaaaattctt cttatatgtg
     5161 ctaaaggtaa aaatagctat atggcgcaaa atcgcttaag acgctttggc tatacaaata
     5221 cgaaagttct tgaaggtgga atactatttt atccaaatct taaggtaatg gaggagtaaa
     5281 tatgagtaat gttacagcag aacaaaaaaa ggaagtaaaa ggtagaggtt ttctaccaag
     5341 cagggatgga gaacattttg cagcacgtat aataactgta aatggtgtaa taaatgcatc
     5401 acaagcaaaa aaaattgcag aagctgctga aaaattcgga aacggtcagt tagcatttac
     5461 tactagacta acagtagaat tacctggtgt aaaatttgaa gatattgaag ctctaagtga
     5521 atttattgct agcgaaaatc taataacagg tggaactgga tcaagggttc gtcctgttgt
     5581 ggcttgtaaa ggtactgttt gtgttcatgg tctagctaat acacaggcac ttgctgctga
     5641 aatacatgaa gaattttaca aaaattggta tgatgtaaaa ctacctcata agttcaaaat
     5701 tggtgttggt ggatgcccta ataactgtat taaacctgac ctaaacgatc ttggaattgt
     5761 tggtcaacgt gtacctgact atgattcaga gctttgtgtt ggttgtaaaa aatgtgctgt
     5821 tgtagaggtc tgtcctgtta aagcagctaa attaacagat aaaggtaaac ttgaaataga
     5881 tagtaatcta tgtaataact gtggtaagtg tatagaaagt tgtaattttg atagtattga
     5941 agaaaaagaa tctggttata aagtctatat aggagggaaa tggggaaaat cagttcgtcc
     6001 tggaacacag attgatagat tattttcaaa agaggaactt atgactttaa ttgaaaaagc
     6061 aattctttta tttagagaac agggtaacac aggtgaacgt tttggaataa ctatcgatag
     6121 aatcggtgct gataaattta tagaaatgct tttatcagat gaagttttgg aaagaaaaga
     6181 agagatacta gaggctcttt tacaccttac aggtggagct gtatgctaac aataaatatt
     6241 ttaattgtac agataaccta tggaaaaaat tttagttaag aataattaaa attctatata
     6301 tgatatatga taaatgaggc tatctcaaaa cacagatacg cctctttttc attgttgaaa
     6361 tgataaagta tatttgagtt catataaaaa agagtgtctc atgaattata aaattcattt
     6421 tgaggcaccc acattatttt ataataattg cttattaatt ttattttaac tatataaaat
     6481 gtacaaaaat taagaatatc caatattcta aaattaattt tgaattgtat tgattgaaaa
     6541 gtttactatt ccactatttc catcttgatt tactactaga taccatgttc cagtattagg
     6601 aactctcatt ctacatggat ttttctttgc aaatccacca tagtaatcat aatttctttg
     6661 atttttaaat ttcacataat ttatatggtc taacaatatt acattggctt gtttctctaa
     6721 atttacctct acaatatccc ctttttttaa gttcatctta ctataactat attccattga
     6781 attactcctc cagtatcgaa taatctttgt tatttactca tctcaaatat gtaaaaattc
     6841 atttaaaata ttacaaatac tatataatta gactattatc cagttttaac cttatttact
     6901 acaatccaaa ggttattaaa aatattattg gcaacaactt ctccatccca tacaactctt
     6961 tcttctttat tttctaataa agcatagtac ccagagtcag aactttcatc tttatagact
     7021 gtaacataaa actcttcatc actatattca ggtatatttt taaagtcttc agatatttta
     7081 catgttaata tataaccttc taattcttca tctataaaca aag
//
LOCUS       DAEHWM010000145         6706 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.148, whole genome shotgun sequence.
ACCESSION   DAEHWM010000145 DAEHWM010000000
VERSION     DAEHWM010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6706)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6706)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6706
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.148"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            560..865
                     /locus_tag="KNP36_003510"
     CDS             560..865
                     /locus_tag="KNP36_003510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875339.1"
                     /translation="MPSMIMEVVGVLFIAIGLILTFIEIKGNFPSFYGFGQNSIGKNA
                     VGIIAAGIALIFFRNGIDSIDSIATYGVFLAIELVVIVAYFLIRKKFTKEDKHLRTN"
     gene            1273..1962
                     /locus_tag="KNP36_003511"
     CDS             1273..1962
                     /locus_tag="KNP36_003511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875340.1"
                     /translation="MDILLVEDDKNIREMVYDFLISENYSVKTAIDGNTAIEIFKNYS
                     FDIILLDLMLPKSSGFEVLKYIRSVSVVPVIITTAKDSDTDKMLGLNLGADDYITKPF
                     SIVELLARIKANIRRATVYSSSRNSEDMVIQYKDLIINISKYVVSKNGIDLNLTHTEF
                     EIVKLLATNQGRAFSKEQLYNAIWKEPYYGNENVLNTHINRLRNKLSDGIEKNNYIKT
                     LWGIGYKMEEE"
     gene            1962..2879
                     /locus_tag="KNP36_003512"
     CDS             1962..2879
                     /locus_tag="KNP36_003512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HBF0875341.1"
                     /translation="MELFLVVISIVLFALYLKERNKSKKMESDYKYINSRLRDITNDD
                     EINYILVPSDISIVKETAVDINKLLEKFYSRQINYNRSEKAMLQIFTNISHDLRTPIT
                     VLKGYIEMLYLQSQKEELSSSMRATVEKMQTNSNELVNSINNLFNMAKIQSGDMILNL
                     QKSNLTQLCHEIILEFYDLLDKENFNVEVNIEDRPIYANVDTEALQRILKNLIDNAIK
                     YGSDGRFLGISLYEKEKHVFIDIEDKGSGISETEKEHIFTRAYTADRKKGNGLGLAIS
                     QGLVNSMGGSIYVNSRPNVKTVFTVKLKS"
     gene            2952..3878
                     /locus_tag="KNP36_003513"
     CDS             2952..3878
                     /locus_tag="KNP36_003513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875342.1"
                     /translation="MNYIIETNQLKKIYKDKAVVNAVNIHVKKGEIYGFVGPNGAGKS
                     TVMKMLLNLVKPNSGEIVMFGKKVAETDFEILKKIGTIIENPYLYENLTAKQNLDLHC
                     EYMGYYNKEHISEVLECVGLSKQSNKKVSKYSLGMKQRLAIARAILTKPELLILDEPI
                     NALDPEGIREMRELFRKLNTDYGITIFISSHILSEVEQIADTIGIIQDGKLIKEISMS
                     DIHKYQTDYVEVDVDNVELAGYLLEKEFGIKDFKITSESCIEIYDLRKDVKEISKIFI
                     QNQIGINSIGRKQSSLEDYFFQTTGTGGKETL"
     gene            3875..4555
                     /locus_tag="KNP36_003514"
     CDS             3875..4555
                     /locus_tag="KNP36_003514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875343.1"
                     /translation="MIHLMKLELKKVGLKRYFLFSMLGIFLCMFFVFTGLNDKSTSIY
                     DYDVTFRTISLFFCFYYIILFAVLNVAYIINEYTNKTILILFSYPLDRKKLILSKLLL
                     ITTLMISSMIVGYICCFTFVVVLDKYFNLVIGDFHISILSYWIPGAIKSIIVFCSLGI
                     WTFVVGMIRKSIPVTLVSSIIFINLRQFILAGTNTTQDSLISVFIIVGITVIGIYYIL
                     NHKVTEID"
     gene            4653..4988
                     /locus_tag="KNP36_003515"
                     /pseudo
     CDS             4653..4988
                     /locus_tag="KNP36_003515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427885.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
     gene            5972..6622
                     /locus_tag="KNP36_003516"
     CDS             5972..6622
                     /locus_tag="KNP36_003516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905011.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HBF0875344.1"
                     /translation="MKVKSNLDEILYHKIIESLIRGEYSVGQKILLNDLCEKFEVSRT
                     PVVQAVKMLNKDGVLTIMTNGKVYVPEYEYDMVKQVCETRTLIETYALEKMMQEEEEV
                     FQQKLDVIKRYSDKCEEYYRQEKSVELALADLELHKAIVEGANNEILNDVYVGIQGRF
                     IVVNYLIRPLKNRNYEGTVQDHFEILKFIEDRDTKKAVDKLRNHIQGTIKRFCEDE"
BASE COUNT         2672 a          675 c         1041 g         2318 t
ORIGIN      
        1 taaaaatcaa gctcatagat taaaaaataa atgatttata gatgaagaac taaacttata
       61 gattaaaaaa taaatgactt atttatagat gaaaaaccaa acttatagat taaaaaataa
      121 atgatttata gatgaagaac taaacttata gattaaaaaa tgacttattt atagatgaaa
      181 aaccaaactc atagattaaa aaataaatga cttatagatg aaaaatcaag ctcatagatt
      241 aaagaataaa taacttatta gatgaaaaac caagcttata gataagaagt ccatgcttat
      301 aagccagaaa atgaatactt taatagatta aaaaatacat atttgtgaat tatagaatga
      361 atgactccat aaactagaaa atttataata atatctatat aaaaattaga agtattttat
      421 cacaaaaaaa ttaagttaaa taaatatgaa attacttcca aatatacttc caaaaacatg
      481 taatcgcata tataatataa ttataaaaat aataaatatt tttatagtag tagttaatta
      541 ttaataagga ggggtcaaaa tgcctagcat gattatggaa gttgtaggag tactatttat
      601 agctattgga ttaatcttga cattcattga aataaaagga aatttccctt ctttttatgg
      661 ttttggtcaa aattctatag ggaaaaatgc tgtaggtatt atagcagcag gaattgcttt
      721 aattttcttt agaaatggca tagatagcat agattctata gctacttatg gtgtattttt
      781 agcaatagaa cttgttgtaa tagttgcata tttcttaata agaaaaaaat ttactaaaga
      841 agataaacat ttaagaacta attaactaaa ttatctacta taaaattgga aaattaaaaa
      901 caaataaaag tttgttttta attatttaaa atccaaattt gattattttt aaagaaacta
      961 tgttctgtat aaaactagaa tgtggtttct tttttatgta taaaatattt tttagcaaga
     1021 gttaaaaggt gttttataat ataaaatagt taattgtaga tgttaataaa agaaaattat
     1081 gtatatttca gataaagata agagagtata ctatatttta attatttttt caataaagct
     1141 tattgaaaag aactttaact tagaagagta tcaccaaatt gcagatacaa tatcataagc
     1201 agttatttat tgacaaccct ttttaataaa tatatcattt gaagtatact gacgaaaagg
     1261 agttgaataa taatggacat cttattggtt gaagatgata agaatattcg agaaatggta
     1321 tacgattttc tgattagtga gaattactct gttaaaactg ccattgatgg aaatacagct
     1381 attgaaatat ttaaaaatta ttcatttgat attattttac tggacttgat gttaccaaag
     1441 tctagtggtt ttgaagtatt aaaatatata cgaagtgtga gtgttgttcc tgttattatt
     1501 actactgcga aagatagtga cacagataaa atgctagggc ttaatcttgg tgcagatgat
     1561 tatattacaa agcctttttc aatcgtagaa ttgcttgcaa gaattaaagc taatattaga
     1621 cgtgcaacag tgtacagcag ttcaagaaac tctgaagata tggttattca gtataaagat
     1681 ttgattataa atatatcaaa atatgtagtt tcaaagaatg gaattgactt aaacttaaca
     1741 catacagaat ttgaaattgt taaattacta gcgactaatc aaggacgtgc tttttcaaag
     1801 gaacaattat acaacgctat ttggaaagaa ccttattatg gaaatgaaaa tgtgctaaat
     1861 actcatatta acaggttaag aaataaattg tctgatggta tagaaaaaaa taattatatt
     1921 aaaactcttt ggggaattgg ctacaaaatg gaggaagaat aatggagtta tttttagttg
     1981 taatttcgat tgtactattt gctctctact taaaagaacg aaataaatca aagaaaatgg
     2041 aaagtgatta taagtatatc aattcaagac ttcgtgacat aacaaatgat gatgaaatta
     2101 attatatttt agtaccatct gatatttcga ttgtaaaaga aacagcagta gatataaata
     2161 aacttcttga aaagttttac agcaggcaaa ttaattataa tagaagtgaa aaagcgatgt
     2221 tgcaaatatt tacaaacata tcacacgatt tacgaactcc catcacagta ttaaagggtt
     2281 atattgaaat gttatatctt caaagtcaaa aagaagaatt atcttcttca atgagagcaa
     2341 ctgtggaaaa aatgcaaaca aattcaaatg agcttgttaa ttcaataaat aacctgttta
     2401 atatggcaaa aatccaatct ggagatatga tattaaatct tcaaaaatcc aatctaacac
     2461 aattatgtca tgagattatt ttagagtttt atgatttgct agataaagaa aactttaatg
     2521 ttgaagttaa tattgaagat agacctatat atgcaaatgt tgacacagaa gcattacaac
     2581 gtatactcaa aaatttaatt gataatgcta taaaatatgg ttcagatggt agatttttag
     2641 ggatttcact atatgaaaag gaaaaacatg tttttataga tattgaggat aaaggttcag
     2701 gtatttctga aactgaaaaa gagcatattt tcacaagagc ttatactgct gacagaaaaa
     2761 aaggcaatgg tttaggtttg gctatttctc aagggcttgt aaactctatg ggaggttcaa
     2821 tttatgtaaa tagtagacct aatgtaaaaa cagtttttac agtaaaattg aaaagttaga
     2881 aaaaagttag atttaaaaga gagaaaagat aattttattt tgtatactgt ttttagaaag
     2941 gagggagtat gatgaactat atcatagaga ccaatcaatt aaagaaaata tataaagata
     3001 aagctgttgt taatgctgtt aatattcatg tgaaaaaggg agaaatttat ggatttgttg
     3061 gaccaaacgg ggcaggtaaa agtacagtaa tgaaaatgtt gctaaatctt gttaagccaa
     3121 attctggaga aatagttatg ttcggtaaga aagtggcaga aactgatttt gaaatattaa
     3181 aaaagattgg tactattatt gaaaatccgt atttatatga gaatttgact gctaaacaga
     3241 atcttgattt acactgtgaa tatatgggtt attataacaa agaacatata tcagaggtat
     3301 tggaatgtgt cggattgtca aagcaatcaa acaagaaagt ttcaaaatat tctttaggga
     3361 tgaaacaacg tcttgcaata gctagagcaa ttcttactaa accagaatta ttgattcttg
     3421 atgaacctat aaatgcactc gacccagagg ggataagaga aatgcgagaa ttattccgta
     3481 agttaaatac agattatgga ataactatat ttatttctag tcatattctt tcagaggtag
     3541 aacaaattgc ggacactatt ggaattattc aagatggtaa acttattaaa gaaatttcta
     3601 tgtcagatat acacaaatat caaacagatt atgttgaagt agatgtagat aatgtggagc
     3661 ttgctggata cttgttagaa aaagaatttg gaataaaaga ctttaaaatt acttcggaaa
     3721 gttgtattga aatatatgat ttacgaaaag atgtaaaaga aatatccaaa atatttattc
     3781 aaaatcaaat tggtataaat agcattggac gtaaacaaag ttctttagaa gattacttct
     3841 tccaaactac aggtacagga ggtaaagaaa cactatgata catttaatga aactagagct
     3901 aaaaaaagtt gggctaaaaa gatatttttt attttcaatg ctggggattt tcttatgtat
     3961 gttttttgtc tttactggat tgaatgataa atctacttca atatatgatt atgatgttac
     4021 atttaggaca atcagtttat ttttctgttt ttactatatt atattatttg ctgtgttgaa
     4081 tgtggcatat ataataaatg aatatacaaa taaaacaatc ttgattttat tctcttatcc
     4141 acttgaccgt aaaaaactta ttttatcaaa gttacttttg attacgactc ttatgatatc
     4201 atcaatgata gttggatata tctgttgttt tacattcgtt gttgtgttgg ataagtattt
     4261 taatttagtt attggagatt ttcatatttc aattttatct tattggatac caggagcaat
     4321 taaaagtatt attgtatttt gctcattagg tatatggaca ttcgttgttg gaatgataag
     4381 aaaatcaata cctgttaccc ttgtcagttc aattattttt atcaatttaa gacaatttat
     4441 tttagctggt acaaatacaa ctcaagacag tttgatttct gtttttatta tagttggtat
     4501 aactgtgatt ggtatatatt atatactaaa tcataaagtt actgaaattg actagatact
     4561 gtggatagga aggtagttat taattgtatc ttctcgggat aataatgatt tgctattata
     4621 tcagctatta ttaatattat tagagtttta ataatattgc acaaccattt gaagttgagc
     4681 caaagcttga tgaattaatt gaatggtact atagtcagag tgaagtatct attaaagtta
     4741 taactgaatt tcattataga tttgaattga tacatccatt tcaagatggt aatggtcaca
     4801 taggtagatt tgttatgcta aaacagatgt tagaaaataa tcttcctata aaaattgtat
     4861 cttgggatag tgaggaattg tatagaaact ccttaaattc ttgtagttta ggtaattatg
     4921 tccctttaat tgaatattta tcaagtttag aagattttag agaagtatat aaaatgttat
     4981 ggaaataatt gtttgcagca aaaaaagttt atatataaat gtatttttat ctatgctatt
     5041 taacgctaat ttcttagtta ttcttagctt ggactatacc cactatttta actatataaa
     5101 atagtggata tagtttaact atctctttat aactattttt atgtatctta gttgtttctt
     5161 aatatgggga cagttcataa aactaaaagt gatttttaat tttatcattt ataatttacc
     5221 attacatcag aaaaatgctt atcattagaa ttttcataaa aggtacctat ttttttcaat
     5281 taactgaatc aattctatta gtcttaatct ttcatatttc aaattgataa tataagaaaa
     5341 taaaaaataa aaaattttaa attttttatt tattgcgaaa aaaataaaaa ggtgctatac
     5401 tttttgtaac atattattca aattattaag agatagtaaa catttatagt ttaatttgta
     5461 gtacactagc atgatttgca gaacaatgaa ttaatctata gtataatagt ttaatttaaa
     5521 gtacaacgat ttaatctata gtacaataac ttgatttgaa gtacaacgat ttaatctata
     5581 gtacaataac ttgatttgca atacaatgaa ttaatctatg gtataatagt ttaatttgaa
     5641 gtacaatgaa ttaatctata gtataatagt ttaatttgaa gtacaacgat ttaatctata
     5701 gtataatagt ttaatttgaa gtacaatggt ttaatctata gtataatagt ttaatttgaa
     5761 gtataacgat ttaatctata gtacaataac ttgatttgca atacaatgaa ttaatctata
     5821 gtataagagc atgatttaca gtacaataat ttaaattgta gtacaaaagt actatcaaat
     5881 aagaatttct actttaaaaa tattactaaa agtaattaaa gtccagtaat tcaatataat
     5941 atggcaaaag aatagaaata aggtgagagt agtgaaagta aagtcaaatt tagatgaaat
     6001 tttatatcat aagattattg aaagtcttat tcgtggtgaa tactctgtag gtcaaaaaat
     6061 attactaaat gacctttgtg aaaaatttga agtaagcaga acaccagttg tacaagcagt
     6121 aaaaatgcta aataaagatg gagtgcttac tattatgaca aatggtaaag tgtacgtacc
     6181 agagtatgaa tatgatatgg taaaacaagt ttgtgaaacg agaacactga ttgaaacata
     6241 tgctttagaa aaaatgatgc aagaagagga agaggttttt caacaaaagc tagatgtaat
     6301 aaaaagatac tctgataaat gcgaggagta ctatcgtcaa gaaaaatctg tagaacttgc
     6361 actagcagat ttggaattac ataaagccat tgtagaaggg gcaaataatg agattttaaa
     6421 tgatgtatat gttggtatac aaggaagatt tatagtagtg aactatttaa ttcgaccatt
     6481 aaaaaatcgt aattatgaag gaacagtaca agaccatttt gaaatattaa aattcattga
     6541 agacagagat acaaaaaaag cagtagataa actaagaaat catattcaag gaactattaa
     6601 aagattctgt gaagatgaat aataagtttt gaagttacta tatatactta tctattaagt
     6661 tgctaaatgt agtctaagta taatctaatt atagtttaaa cataat
//
LOCUS       DAEHWM010000146         6640 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.149, whole genome shotgun sequence.
ACCESSION   DAEHWM010000146 DAEHWM010000000
VERSION     DAEHWM010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6640)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6640)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6640
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.149"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..1276)
                     /gene="hflX"
                     /locus_tag="KNP36_003517"
     CDS             complement(<1..1276)
                     /gene="hflX"
                     /locus_tag="KNP36_003517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HBF0875345.1"
                     /translation="MDMAKKGITVGLNINNKSEDFNELMIELENLCSACDIDVVGSIT
                     QNAKQVNRAFYIGTGKVEEILNLIKKENIEIVIFYNELSTSQLKNLEEKLNCEIIDRT
                     ALILDIFAQRAKTREAKLQVEVASLKYMLPRLIGSNENLGRQSGGVGTKNRGSGEKKL
                     ELDRRRIEEKITSLNRELDDLKFQRETQRSMRRKSNLPNVALVGYTNAGKSSIMNKLV
                     DIFKNSEEKKVFEKNMLFATLETSVRNIVLANNKEFLLSDTVGFVSNLPHDLVKAFRS
                     TLEEACEADVLLHVIDISNPSYKSHIKVTEDTLKQIGADGIPMIHVYNKIDLIDVEVL
                     DRILDSIDKEGIFVSVKKDINIDKMIKCICDSIFKDYVRCKFLIPYDKGHVVSYFNEN
                     TSIINTEYREDGAILDVECSNIEYNKYKKYALE"
     gene            complement(1995..3827)
                     /locus_tag="KNP36_003518"
     CDS             complement(1995..3827)
                     /locus_tag="KNP36_003518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875346.1"
                     /translation="MSRMGRGPMGKSMGAGQKANDFKGTMRKLIAYLSKFKISIILVI
                     VFAIGSASFSIVGPKILGKATTKIFEGLVSKVSGGNVGIDFNAIGKILTFLLFLYLIS
                     ALFSFIQGFIMSGISQKVSYNLRKEISAKLDRLPMKYFDTKTHGEILSRITNDIDTLN
                     QSLNQSMTQLITSVTTMIGVLIMMLSISGIMTLVAVLILPISMFVISRIIKKSQKYFR
                     YQQEYLGNVNGQVEETYSGQTIVKAFNREDEVIEEFDKLNDSLYNSAWKSQFLSGIMQ
                     PLMMFIGNLGYVMVSILGGWLAIKKTIEVGDIQSFIQYVRNFTQPMTQIAQVANLLQS
                     TAAASERVFEFLEEEEEVQIVENAVSIDGLEGKIDFENVNFGYNPNKTIINDFSVNVK
                     PGQKVAIVGPTGAGKTTIVKLLMRFYDVNSGSILIDGHNIKDFNRSELREMFGMVLQD
                     TWLFSGSIMENIRYGKLNATDEEVIEAAKSAHVHRFIKTLPDGYKMKLNEEASNVSQG
                     QKQLLTIARAILADPKILILDEATSSVDTRTEVLIQKAMDNLMEGRTSFVIAHRLSTI
                     RDADMILVMNEGDIVEQGNHEELLKKGGFYANLYNSQFEEDEAM"
     gene            complement(3820..6066)
                     /locus_tag="KNP36_003519"
     CDS             complement(3820..6066)
                     /locus_tag="KNP36_003519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011009877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875347.1"
                     /translation="MFKLIKYLKKSALSIVIIVCLLVIQAVCDLSLPEYTSNIVNVGI
                     QQGGVENSVPSVIRESELNKITLFMDKSSKDKVLDNYTLLNKKDYVKYKDKYPGLKDE
                     SLYELNTKDKDTIDDLNVIFGKAILIVSGLEGDSKEVKAMKAQLMSKLPPQATQSGDV
                     DIFKLLSAMPKEQLDTLTKEMSKGFESMPESMITQSSVSYVRSEYEKIGIDTEKTQNN
                     YILFTGAKMLGIAMISMVATITVGFLAARVAASVGRNLRSGVFRKVMSFSNTEMNEFS
                     TASLITRSTNDIQQIQMLMVMLLRIVFYAPIMAIGGVIKVLNTNTSMAWIIAVAVVAI
                     LSLIVVLFSVVMPKFKLVQKLVDKLNLVSREIITGIPVIRAFSTEKHEEERFDKANKN
                     LTKTNLFVNRVMTCMMPAMMLIMNLITVLIVWRGAYSVDSGAMQVGDMMAFIQYTMQI
                     IMSFLMISMVSIMLPRASVSATRIDEVLVSDISIKDPEKSEAQEFKEDKKGLVEFKNV
                     SFMYPDAEEPILTNISFTAKPGETTAFIGSTGSGKSTLINLIPRFFDVTEGEILLGGV
                     NIKNVSQHDLREKIGYVPQKGVLFSGTIESNLKYGRKDATDEEMRTAAEIAQATEFID
                     SKPEAFKTEISQGGTNVSGGQKQRLSIARAIAKNPEVYIFDDSFSALDLKTDAALRKA
                     LKSKTAESTVLIVAQRISTILNAEQIIVLNEGEIVGIGTHKELLKNCEVYEQIALSQL
                     SKEELANE"
     gene            complement(6134..6595)
                     /locus_tag="KNP36_003520"
     CDS             complement(6134..6595)
                     /locus_tag="KNP36_003520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HBF0875348.1"
                     /translation="MNSNSEEKLNDVFLQLMRIYFIRTHFYFDKLGLYHGQPQILFSL
                     KMKDGQSQKELADKRKVKASTTTVMIKRMEKAGLVERKQDEKDQRVSRIFLTDKGLEI
                     CNKVEEFNKELEREFFLGFSEEEKIVLRRLLMQVRDNLKAGCHKHEDEKYF"
BASE COUNT         2100 a         1228 c          710 g         2602 t
ORIGIN      
        1 actctaaagc atacttttta tacttattat attctatatt gctacattct acatctaaaa
       61 tagctccatc ttctctgtat tctgtattta taatgctcgt attttcgtta aaataagaaa
      121 ctacatgacc tttatcatat ggaattaaga acttacatct tacataatct ttaaatatgc
      181 tatcacaaat acattttatc attttatcta tatttatatc ttttttaact gaaacaaata
      241 taccttcttt atcgatacta tctaaaattc tatccaatac ttctacatct attaaatcaa
      301 ttttattata cacatgtatc ataggtatac catctgcacc tatttgtttt aaagtatctt
      361 ctgtcacttt aatatgactt ttatagcttg gatttgaaat atcaataaca tgtaacagta
      421 cgtctgcctc acatgcttct tctaatgttg acctaaatgc ttttactaag tcatgtggta
      481 gattacttac aaaaccaaca gtatcagata ataaaaattc tttgttattt gcaagaacta
      541 tatttctgac agaagtttca agtgtagcaa ataacatgtt tttctcaaac actttctttt
      601 cttcagagtt tttaaatata tctactagtt tattcattat tgaagattta ccagcatttg
      661 tatacccgac tagagctaca tttggaagat ttgattttct tctcatactt ctttgagttt
      721 ctctttggaa ttttaaatca tccaactccc tatttaaaga tgttatcttt tcttctattc
      781 ttctacggtc aagttctaat tttttctcac cagaacctct atttttagta ccaactccac
      841 cactttgacg tcctaaattt tcatttgaac ctataagtct tggtaacata tattttaaac
      901 ttgctacttc tacttgaagt ttagcttctc tagtttttgc cctttgtgca aatatatcaa
      961 gtatcaatgc cgttctatct ataatttcac aattaagctt ttcttcaaga ttttttagtt
     1021 gtgatgtaga aagttcattg taaaatataa ctatctctat attttctttc tttattaagt
     1081 ttaatatttc ctcaacttta cctgtcccaa tgtaaaatgc tctattaacc tgctttgcat
     1141 tttgagttat actccctaca acatcaatat cacatgctga acataagttt tcaagttcaa
     1201 tcattagttc attaaagtcc tcagatttat tatttatgtt taatcctact gttattcctt
     1261 ttttcgccat atccatattc tccttatctg ctatttttta tttaatctat agcacgagat
     1321 tatggctcta taattaaatt catcaagaat tttgcttttt atcttatcct taaatgacac
     1381 ttcttattta ctattataat aaccataatc gtgcattatt ttctcaatct tatataaaaa
     1441 atcactttct tacacctcct cccaaatata ttatgcagtt ttttcaataa aaaaactcct
     1501 tacaaatcta agtaatacaa aacaagctac ttatatcata agaaggatta aaattctaaa
     1561 tatatattaa aaatacatta gtttaattaa cttatatgta attatcattt tatatttaac
     1621 cctattctta aatttaagta gttatttgca tgattaataa aagtaataaa aacatatact
     1681 tcaatataat catcaactat taaaattaaa ttctatttat aataaaattt aaagaataaa
     1741 attaaatata cattttgata atcacctcca acattttcct tactacatat tataataaaa
     1801 taaacacttt gtaaagacat aaaattatgt ggctatctca aaatatagag aatcctcttt
     1861 ttcattgtta aaatgataaa aatacacttt atttcataca caaaagagtg ccttatgaat
     1921 taaaaagttc attttaaggc accctcattt attttatctt attaattaca tgtctatgct
     1981 aagatagttt tttgttacat tgcttcatct tcttcaaatt gagaattgta aagattggca
     2041 tagaatccgc ctttctttag aagttcctcg tgatttcctt gttcaactat atctccttca
     2101 ttcattacaa gaatcatatc agcatcacgt atagttgata atctgtgggc tataacaaaa
     2161 cttgttctac cttccataag attatccata gctttttgaa tcaatacttc tgttctagta
     2221 tcgacagaac ttgtagcttc atctaatatt aaaattttag gatcagctaa aatagcacga
     2281 gctatagtca ataattgttt ttgaccttga gaaacattac ttgcttcttc atttaatttc
     2341 atcttatatc catctggtaa tgtcttaata aatctatgaa catgtgcaga tttagcagcc
     2401 tctataactt cttcatctgt agcattcaac ttaccatatc ttatattttc cataattgaa
     2461 ccactaaata accatgtatc ttgaagaacc ataccaaaca tttctctaag ctcactacga
     2521 ttaaaatctt taatattatg accatcaatc agtattgaac cgctattaac atcataaaat
     2581 ctcattaaca gtttaactat tgtagtttta cctgctcctg taggtccaac aatagcaact
     2641 ttttgaccag gtttaacatt tactgagaaa tcatttatta tagtcttgtt tgggttatat
     2701 ccaaagttga cattttcaaa atcaatttta ccttctaaac catctattga aactgcattt
     2761 tcaacaattt ggacttcttc ttcctcttct aaaaactcaa atactctttc agaagctgct
     2821 gctgttgatt gcaataaatt ggcaacctgt gcaatctgag tcattggctg tgtaaagttt
     2881 cttacatatt gtataaatga ctgtatgtca ccaacctcaa ttgttttctt aattgcaagc
     2941 caacctccta agattgatac cattacatat cccaagtttc caataaacat cataagtggt
     3001 tgcattatac ctgataaaaa ttgagatttc cacgctgaat tatacaggct atcatttagt
     3061 ttatcaaact cttcaattac ttcatcctca cgattaaatg cttttactat tgtttggcca
     3121 ctgtaagttt cctcaacttg accatttaca tttcctaaat attcttgttg atatctaaag
     3181 tatttttgtg atttctttat tattcttgaa attacaaaca ttgatattgg taatattaaa
     3241 actgccacta atgtcataat tccacttata gataacatca ttatcaaaac acctatcata
     3301 gttgttactg atgttataag ctgtgtcata ctttgattta aactttgatt taaagtatct
     3361 atatcattcg taattctcga taatatttca ccatgcgtct tagtatcaaa atacttcatt
     3421 ggcaatctat ccaattttgc tgaaatctct tttcttaaat tataggatac tttttgagaa
     3481 attccactca ttataaatcc ttgtataaaa gagaacagtg cacttatcaa ataaaggaaa
     3541 agtaaaaagg ttaagatttt tccaattgca ttaaaatcta tacctacgtt tcctccagaa
     3601 actttactca ctagcccttc aaatatcttt gtagttgcct ttcctaaaat ttttggacct
     3661 actatagaaa acgacgcact accaatagca aatacaatta ctagaattat tgatatttta
     3721 aatttagata aatatgcaat tagttttcgc atagtccctt taaagtcatt tgctttttgt
     3781 cctgctccca tagattttcc cataggacct cttcccattc tactcattag ctagctcctc
     3841 ctttgaaagt tgtgataaag ctatttgctc ataaacttcg caatttttta gaagctcttt
     3901 atgtgttcct attccaacta tttcgccctc atttaaaaca attatctgtt ctgcatttaa
     3961 gatagtacta attctttgtg caactattag aactgtactt tcagcagttt ttgattttaa
     4021 agccttacga agagctgcat cagtttttaa gtcaagtgct gaaaaactat catcaaatat
     4081 ataaacttct ggattttttg ctattgctct tgcaatagaa agtctttgtt tttgacctcc
     4141 agatacattt gttccacctt gagaaatttc agttttaaaa gcttccggtt tagaatctat
     4201 aaattctgta gcttgagcta tttcagctgc tgttctcatt tcttcatctg ttgcgtcttt
     4261 tctaccatat tttaagttgg attctatagt accagaaaac aatactccct tttgaggtac
     4321 atatccaatt ttttccctta aatcatgttg agaaacattt tttatattaa ctccaccaag
     4381 taatatttct ccttcagtaa catcaaagaa acgaggaatt aaatttataa gagttgactt
     4441 accactacca gtacttccta taaaggcagt tgtttctcct ggctttgctg taaaagatat
     4501 atttgttaat ataggttctt ctgcgtctgg atacatgaac gaaacatttt taaattcaac
     4561 aagacccttt ttatcttcct taaactcttg tgcctctgat ttttctgggt cttttatgct
     4621 tatatctgac actaatactt catctatacg tgtagctgaa acggatgctc ttggaagcat
     4681 aatagatacc attgatatca ttaagaatga cattattatt tgcattgtat attgtataaa
     4741 tgccatcata tctccaactt gcattgctcc agaatcaaca ctgtatgcac ctctccaaac
     4801 tataagaact gtgataaggt tcattataag catcatagca ggcatcatac atgtcataac
     4861 tctatttaca aaaagatttg ttttagttaa atttttattt gctttatcaa atctttcttc
     4921 ttcatgtttt tcagtactaa aagctctgat aactggaata ccagtaatta tttcacggct
     4981 tactaagttt aacttatcaa caagcttttg aaccagttta aacttaggca taaccactga
     5041 gaataacact acaattaatg ataagatagc aactactgct actgctataa tccaggccat
     5101 tgaagtattt gtgtttaaaa cctttatcac tccacctata gccattatag gtgcatagaa
     5161 tactattcta agcaacataa ccatcaacat ttgtatctgt tgaatatcat ttgtactacg
     5221 agtaattaat gaagctgtag aaaattcatt catttcagta tttgaaaatg acataacttt
     5281 tctaaatact ccacttctta aatttctacc tacacttgcg gctactcttg ctgctaaaaa
     5341 tcctactgtt attgtagcta ccatactaat cattgctata ccaagcattt tagcaccagt
     5401 aaataatata taattatttt gagttttttc tgtatcaata cctattttct catattctga
     5461 ccttacatat gaaacagagc tttgtgttat catactctct ggcatacttt caaagccttt
     5521 gctcatctct ttagtcaatg tatctaactg ttcctttggc attgctgata acaatttaaa
     5581 tatatcaaca tctccacttt gagtagcttg tggtggaagt ttgctcatta actgagcttt
     5641 catagctttt acctctttac tatcgccctc aagccctgat actattaaaa tagctttacc
     5701 aaaaataaca tttaaatcat ctatagtgtc tttgtcttta gtatttaact cataaagaga
     5761 ttcatctttt agacctggat acttatcttt atacttaaca taatcctttt tattcagcaa
     5821 agtataatta tctagtactt tatccttact acttttatcc ataaataaag taattttatt
     5881 taattcactc tctctaatca cagatggaac agagttttct actccacctt gttgtatacc
     5941 tacatttact atattggatg tgtattctgg taaagaaagg tcacataccg cttgaattac
     6001 caatagacag actattatta ctattgataa tgccgatttc tttaaatatt taattaattt
     6061 aaacatacat ttcttccctt ctgtaatatt aattagtcta ataacattaa attgaaaaac
     6121 attattttaa actttaaaaa tatttttcat cttcatgctt atgacatcct gcttttaaat
     6181 tatctcgtac ttgcattaga agtcttctaa gtactatttt ttcttcttca ctaaatccta
     6241 aaaaaaactc tctttccaat tccttgttaa attcttcaac tttattacat atttctaaac
     6301 ctttgtctgt caaaaaaatc ctagatactc tttggtcctt ttcatcttgt tttctttcca
     6361 caagtccagc tttttccatc ctctttatca taactgtagt tgtagatgct tttactttcc
     6421 ttttatctgc taattctttt tgactttgcc catctttcat ctttaaagaa aaaagtattt
     6481 ggggttgacc atgatataag cctaatttat caaaataaaa atgagttctt ataaaatata
     6541 ttcgcattaa ttgcaagaaa acatcattta atttttcttc agaattgcta ttcatacttg
     6601 ccctccttat tttttatatt acttagtcgg ctaagcatta
//
LOCUS       DAEHWM010000147         6584 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.150, whole genome shotgun sequence.
ACCESSION   DAEHWM010000147 DAEHWM010000000
VERSION     DAEHWM010000147.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6584)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6584)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6584
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.150"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(619..1179)
                     /locus_tag="KNP36_003521"
     CDS             complement(619..1179)
                     /locus_tag="KNP36_003521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-binding protein"
                     /protein_id="HBF0875349.1"
                     /translation="MLKKLKKMLLITCCLFMMSSTAFAETQNSEGKSFTISGYTFMYE
                     NAPQEIKDKYKENCLDIGVEPQPNDEIFITPSELKTYSNIDMYSARSSSFTVTYHYSY
                     YKVTGDKNYTVNTSTIVKYGNSGNPVHLVQLLLKKVGYALEVDSQFGNTTLSKVKSFQ
                     GSYGLTVDGIVGSATWKKFASATNLD"
     gene            complement(1225..2208)
                     /locus_tag="KNP36_003522"
     CDS             complement(1225..2208)
                     /locus_tag="KNP36_003522"
                     /inference="COORDINATES: protein motif:HMM:NF017390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M56"
                     /protein_id="HBF0875350.1"
                     /translation="MSNLILTDILRTSITSSLVICFLLLLRTTIFRIFNKGFNYYIWL
                     IVIVRLLFPFSYFTYTISDSKFQYKPILNEVDYSNTVLIIYLTIVILLAIYRFIKYLK
                     FKSLVIDLSYDIENLEINNLYNNLLKELNIEKHIKLKYTYEINTPSFFGLFDNYILLP
                     PHNYNLNELHWILKHELIHYKSKDLYIRYLVLFLKCVYFFNPFIYLLDRIIYHSCELH
                     CDEVVLKGCSLENIKSYANTILDSIERSSRDSNNYTTGLHRKSNFEKRVYDMFKNKGK
                     SGILIALILCLLSSFTYFKFDSIISKPINHSLDAPLPVNTGKEKSFTITID"
     gene            complement(2221..2583)
                     /locus_tag="KNP36_003523"
     CDS             complement(2221..2583)
                     /locus_tag="KNP36_003523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875351.1"
                     /translation="MIEKIPRAELKVMMLFWDTDKVLTSRDIVNIMSEEWKQTTTLTL
                     LSRLSKRGFLEPTKKPTHTTYKILIDKKSYLEFATSDFVKNVHNDSIVSLVDSVNKEK
                     IGKDELASLRAFIKKLKK"
     gene            3826..4473
                     /locus_tag="KNP36_003524"
     CDS             3826..4473
                     /locus_tag="KNP36_003524"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875352.1"
                     /translation="MNKKLEKPFVYKREYDLTGYDVEILQKYELEQAIYVYVGSSCAY
                     NMRARSSKWRYHIRTNNKSICCNIKNFIHNLELFYKMELKLSDNIINDKLYYSNIAEF
                     EEFETLEKAREVESTIISQYQFLDSINHMLKQKIILLSNKDSVLNITKNGNTNYLKVK
                     NKYIEKHKNKPIMRYHINCQFNTDGSVKSITQEFEPILELNKKNTLSRPSRVFLK"
     gene            4748..6385
                     /locus_tag="KNP36_003525"
     CDS             4748..6385
                     /locus_tag="KNP36_003525"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875353.1"
                     /translation="MEQLDSKYKLKKFLMAVFRDGIGQGNNLIDNEYVRVFQNNKSNS
                     KQLELGEEFKEYSKTTFFKNIDDIVEFTFAKNIYYENTFFNLCTTDGKAGTNENLINR
                     YALGFDFDKKELGQGFNYKDIINLFTKIGLHYHILVDSGNGFHVYVLINKTNNIKLVS
                     EVTNTLINKLGADKQANLSTQVLRVPYTYNIKNTTKQVKIIHQDKNIYRYDIEKLAKK
                     YCKDVKTVGNTNTKYILDSKLPNCIVDILKNGSKDGHKNLDLQKIVVTLRLRNKSLSQ
                     VISVAREWNYISQNSLSNSELEYQVKYMYEKLKTVNFGCTGCEFNSDCWNKIESDFIY
                     SDEDTLFNMPHKHSKDLKYKNRKGVKIMTGNQLFIYNVLLNNKDRELNIDDIMELITY
                     KRKKKVKNIVMSEKTLRETLKELQHNDYITKTKGVTKLGIKDTYNVKEVRCNIDKQYT
                     ISYFVTMAVIWGIISTEELRLYTHMRYKQDLLVKDDKIKGNILRINQEELAKDLGVTQ
                     QRISNMIESLLDTKILDVWETKINDRGFMYYTYRLNK"
BASE COUNT         2683 a          692 c          917 g         2292 t
ORIGIN      
        1 ctaattagta ggtgcttttt taaaacaagt taaaaatcaa aaatagtatt agtaagcatt
       61 ggaaatgcta gattctaaaa tagaaaagta aaaaattggt gcactatcta aacttatcta
      121 tatcgctttt tccgtcgttt ggttctctag ttacgataca ggggatatgc ttatattgag
      181 ttatagtact aatcagtgct taatatagtt aataaaatta tagttaccat agtttagtaa
      241 ctatgatgta tgttagttag aaacttgcat ttcatgagtt gtaatatctt aaagtcagta
      301 gttttgattt taaaatatta attgcactgt tacaaatgac tttattaata aaaaattagg
      361 cagcttaaaa aaagtttaga ataaatttgc taggctttgc taagctattc ttttaaaaat
      421 aactttacaa aacaaacaaa taaggactta taaatataga taaaaaaaga aaattgaaaa
      481 ggattataga gacttacaag gctttaaata tatattctta attgtaaaat tatgtaatta
      541 aaatatttac tttattataa aaagacatga taaacttatt atcatgtctt ttgttaaact
      601 tatttatatg taaaaattct aatcaaggtt tgtagcagat gcaaattttt tccatgttgc
      661 actaccaaca attccatcta ccgttaagcc ataactgcct tgaaaacttt taactttgct
      721 aagtgtagtg ttcccaaatt gactgtctac ttctaaagca tatccaactt tttttaatag
      781 caattgtact aaatgaacag gatttcctga atttccgtat tttacaatcg tagaagtgtt
      841 gacagtatag tttttatctc cagtaacttt gtagtatgaa taatgataag ttactgtaaa
      901 tgaacttgac ctagctgaat acatgtctat gttgctataa gtttttaatt cactaggggt
      961 aataaaaatt tcatcattag gttgtggctc tacacctata tccaaacaat tttccttata
     1021 tttatctttt atttcttgtg gtgcattttc atacataaat gtgtaacccg aaatagtaaa
     1081 gctttttcct tcactatttt gtgtttctgc aaaagctgtg ctactcatca taaataaaca
     1141 acaagtaatt agcaacattt tttttaattt ttttaacata attcctccct ataattttga
     1201 atatatttga ataccagcaa atatttaatc tattgttata gtaaaagatt tttctttgcc
     1261 tgtattaact ggcaatggtg catctaagga gtgattaatt ggctttgata taattgaatc
     1321 aaatttaaaa tatgtaaatg atgacaataa gcataaaatc aatgctatta aaataccact
     1381 cttaccctta tttttaaaca tgtcataaac tcttttttca aaatttgatt ttctgtgtaa
     1441 tccagtagtg tagttatttg aatctcttga acttctttca attgaatcta aaattgtgtt
     1501 agcataactt tttatatttt caagggaaca accttttaat acaacttcat cacaatgtaa
     1561 ttcacagcta tgatatataa ttctatcaag tagataaata aaagggttaa agaaataaac
     1621 acactttaaa aataaaacca aatatctaat gtataaatct ttacttttgt aatgaattaa
     1681 ttcatgtttt agaatccaat gcagttcatt taaattataa ttgtgtggtg gcaaaagtat
     1741 ataattatca aataatccaa aaaatgaggg cgtattgatt tcataagtat attttagttt
     1801 aatgtgcttt tctatattta gttcttttaa taaattatta taaagattgt ttatttcaag
     1861 attttcaatg tcatatgata agtcaataac caaactctta aactttaaat attttataaa
     1921 cctataaatt gcaagtaaaa taacaattgt tagatatatt attaatactg tatttgaata
     1981 atcaacttca ttcaaaatag gtttgtattg aaatttagaa tcagaaatag tataagtaaa
     2041 ataagagaat ggaaaaagta atctaactat tacaattagc caaatataat aattaaaacc
     2101 cttattgaaa attctgaata tagttgtcct taaaagtagc agaaaacaaa taactagact
     2161 acttgtgata ctggttctta aaatatctgt tagaattaaa ttagacatat atagtaccta
     2221 ttatttctta agttttttta taaaagctct caaagatgcc aattcatctt ttcctatctt
     2281 ttctttatta actgaatcaa ctaaacttac aatagaatca ttatgtacat tctttacaaa
     2341 atcagatgtt gcaaattcta agtagctctt tttatcaatc aaaattttat aagtagtgtg
     2401 tgtaggtttt tttgtaggct ctaaaaaccc tcttttagaa agcctagata atagtgtaag
     2461 tgttgtcgtt tgtttccatt cttcactcat tatatttaca atatctcttg atgtcaatac
     2521 cttgtcagta tcccaaaata gcatcattac tttaagttca gcacgtggta ttttttctat
     2581 cataatatgt tcctccatcc taatgttaaa aaaattaata aatgtaattt tattctattg
     2641 aaatagagta ggacagtcaa ttgttttttg attaatgatt tacatatgta gagtaaatta
     2701 aaagaagtat atcacttgaa aagttttaca tacgtagagc atttttatca aatctcttaa
     2761 tttttttaat tgaattatat atgtgaatat aagagtaaat caacttaaaa catgcaaaaa
     2821 attaatattt actgacatgc aactgacaaa tcaacaaaaa taggaattga taaaataagt
     2881 gtatatattg aaattgctat aatacataca aaaatggcat aaaatactaa tttttatgtc
     2941 cttttctact gacatgtaaa aaagtcttgt aagtattgga attactagat tacataggtt
     3001 ttagatgcaa aattgtcgtt ttgtaaaaaa ggctactaaa atttataaaa acaattatta
     3061 attgatataa attatcacaa aaaaagacat ctatttctat gaaaaaaaaa ttttcgtctg
     3121 catgtaaaaa tagctatagt aatgcgtacg aatgttctat tattacagaa ttatttgtat
     3181 gtaaattata ttgaaaatat ctatcagaat tagaatttta tatggataaa acagaactat
     3241 caaataggag tatatagtaa agatttatat aatatgatga cctcgtacaa gcctgtaaga
     3301 gccgtttaaa agttgcttta gtattaatta tctttgaaaa tttaaaatag gtttaaatgg
     3361 cttgttaaat atgatgtatt actattatgt ataggggggt agttatgtag ttacatgttg
     3421 ttttaaaaaa taaatttaac tatagttctt tcacttccac attacaaaaa ataaattgag
     3481 tgtgtatgtt tttaagtaaa aatgatgttt aaatattgaa aaatagagat atagtgtatg
     3541 taaaatttag aatagtgtat gtaattttag gcataaaaat atgtgattaa accttaaaaa
     3601 ccaggaatat agtgtatgca tttttaaaaa taaaaattgt aacctttttg taatctttta
     3661 ttaaaatact tactttaagt ctaaaaatta ggggagatgt aaggatttgg gaaaaataga
     3721 agatgttata atcataaata tggtattcgt aggcttaaag tcaaaaagga ggtgaaatat
     3781 aaatagattt ttagctaaat taagtaagaa ataggaggag atttattgaa caaaaaatta
     3841 gaaaaaccat ttgtatataa gagagagtac gatttgactg gatatgatgt tgaaatttta
     3901 caaaaatatg agttagaaca agcaatatat gtttatgttg ggagtagttg tgcatataac
     3961 atgagagcta gaagtagtaa atggagatac catataagaa caaataataa gtctatatgt
     4021 tgtaacatta aaaattttat acataacttg gaattgtttt ataaaatgga attaaagttg
     4081 tcagataata ttattaatga taagctatac tatagcaata tagcagagtt tgaagaattt
     4141 gaaacactag aaaaagctag agaggtagaa agtactatta taagtcaata tcaattttta
     4201 gattctataa atcatatgtt aaaacaaaaa ataattttat tgagtaataa ggatagtgtg
     4261 ttaaacataa ctaaaaatgg aaatacaaat tatttgaaag taaaaaataa atacatagaa
     4321 aaacataaga acaagccaat aatgagatac catatcaact gtcaattcaa tacagatgga
     4381 agtgtcaaaa gtattacaca ggagtttgaa ccaatattgg aattaaacaa aaaaaatacc
     4441 ctaagccgac caagcagagt atttttaaaa taatatttta agataacaac aaaatgagat
     4501 aatactacta gacaatgaca actcaactac caattgagtt tatggagcta ccaactccaa
     4561 tatcggtcta actgattaag tatctgtagt tatataataa tattgctatc aattttagca
     4621 tcttaacaat attattatac atactaagct aaaattattc aatagttgta aaagttgatt
     4681 agtcaataag tatatattta atgtagtgtt atctcttaaa aaaactagat aaggagataa
     4741 taaatatatg gaacaattag attcaaaata taagttgaaa aaatttctaa tggcagtatt
     4801 tagagatggt ataggacaag gaaataatct tattgataat gaatatgtta gagtatttca
     4861 aaataataaa agtaatagta aacaattaga actcggagaa gaatttaaag aatatagtaa
     4921 aacaactttt tttaaaaata tagatgatat agtagaattt accttcgcaa aaaatattta
     4981 ttatgaaaat acatttttta acctatgtac aactgatgga aaagcaggaa ccaatgaaaa
     5041 cttaataaat agatatgcat taggatttga ttttgacaaa aaagaattag gacaaggttt
     5101 taattataaa gatataatta atttatttac taagatagga ttacattatc atatcctagt
     5161 tgatagtgga aatggattcc atgtttatgt gctaattaat aaaactaata acattaagtt
     5221 agtatcagaa gttacaaata cattaataaa taaattgggt gcagataaac aagcaaattt
     5281 atctactcaa gtattaagag taccttatac atataatatt aaaaatacta ctaaacaagt
     5341 aaaaataata caccaagaca aaaatatata tagatatgac atagaaaagt tagctaaaaa
     5401 atattgcaaa gatgtaaaaa cagtaggtaa tactaataca aaatatatat tagatagtaa
     5461 gctaccaaat tgtatagtag atattttaaa aaatggtagt aaagatggac ataaaaacct
     5521 agatttgcaa aaaatagttg tgactttaag attgaggaat aaaagtttaa gtcaagtaat
     5581 atccgttgct agagaatgga actatatatc acaaaatagt ctttcaaata gtgagctaga
     5641 atatcaagtc aagtatatgt atgagaagct taaaacggtt aattttggtt gtacaggttg
     5701 tgagtttaat agtgattgtt ggaataaaat agaatcagat tttatatata gtgatgaaga
     5761 tactttgttc aatatgccac ataagcactc aaaggatttg aaatataaga ataggaaagg
     5821 ggttaaaata atgactggta atcaattgtt tatctataat gtgttactta acaataaaga
     5881 tagagaatta aacatagacg atataatgga gctgataacc tataaacgta agaagaaagt
     5941 taaaaacatt gttatgagtg aaaagacatt aagagaaaca ttaaaagaac ttcaacataa
     6001 tgattatatt acaaaaacaa aaggtgttac aaagctagga ataaaagata catacaatgt
     6061 aaaagaagtt agatgtaata tagataaaca atatactatt agttactttg ttaccatggc
     6121 agtaatttgg ggaataattt caactgaaga attaagatta tatactcata tgagatataa
     6181 gcaagattta ttggtcaaag atgataaaat aaaaggaaat atattaagaa ttaatcaaga
     6241 ggaattagca aaagatttag gagtaacaca gcaaagaatt tcaaatatga tagaatcttt
     6301 attagatact aaaattttag atgtatggga aactaaaata aatgatagag gatttatgta
     6361 ctatacatat agattaaaca agtagatttt tgataggatt agaattgatt ttctagtcct
     6421 atttttatgc aaaaaaacta attaataaaa atttcttttg gtaaaataat tgtacgagaa
     6481 ttgcaaaaaa aaaatggcat caaagtattg aaattaagcc gttttaaaaa tttcttttgg
     6541 taaaataatt gtacatatat atgtagtata tatatatatg tttt
//
LOCUS       DAEHWM010000148         6576 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.151, whole genome shotgun sequence.
ACCESSION   DAEHWM010000148 DAEHWM010000000
VERSION     DAEHWM010000148.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6576)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6576)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6576
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.151"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            102..1244
                     /locus_tag="KNP36_003526"
     CDS             102..1244
                     /locus_tag="KNP36_003526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HBF0875354.1"
                     /translation="MRYVEYGKTGKMVSVVGYGGLRFDLEKSNQENADLVKYAYEKGI
                     NYFDTAPGYCDDRSEDIFGLAFRQMIKEGKTDFYVSTKEKPKACDTSEKAIEAVKKSI
                     ERLGVSKINFYHVWNIRKMEHYELAMRPGGQYEGLLKCKEEGLIDHIVFSSHQPGDEV
                     IDILSENKFEGVTMGINILNFPYRLKGAKYAVDNGYGVVAMNPLSGGTIPKYNKELSF
                     LSKDGESTIESALRFNIGISQISISLIGFNKKQDIDDACKIADENRIYSDEDIHDIET
                     RLNKNMNEICTGCGYCKVCPKGINTPAYMLFYNEKQMFKKSDEEMTKLVYGLGHWNYT
                     MNSKAKAKECISCGKCEVECTQHLPIIDRLKEIKKWEEDGANSVKV"
     gene            1628..2866
                     /locus_tag="KNP36_003527"
     CDS             1628..2866
                     /locus_tag="KNP36_003527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875355.1"
                     /translation="MDGDILMSKILKYKNEMFLFILVVITYLIITKIFFSKTTIFYDL
                     NNTYDVLLDTDTGVLFNLNVFAISQDNSKHILFSAIISIFAYPIYLFCTSIANPGTTD
                     FNSAYGFGLICLQIITSAMSITLVFNHIKKIKMQRLTLILLTMIMIFSFPQLFMTLNV
                     ERFIYSQFSLIFFIVIANKMKGKNSYLVELAAIPLFGITISNIYLYFFNMIFEFKLKI
                     GKMLKHLITFILMAYICVVSTKSYESFMNLGNVIQYDTKFISGEPILEKIAMIIERLL
                     YSVFYFPGASIKKGLFLQNGEVATIPVILTLLALCFCVLSVIENSEKRVPKLCMGIII
                     FNLTLHGIVGYNLVNSSIMAINFSFAVIILLAYFTKALRKNEKNMYNIFLSLLLVTIV
                     ISNVNGFIEILNIGIKSYPV"
     gene            2895..3782
                     /locus_tag="KNP36_003528"
     CDS             2895..3782
                     /locus_tag="KNP36_003528"
                     /EC_number="2.4.2.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="decaprenyl-phosphate phosphoribosyltransferase"
                     /protein_id="HBF0875356.1"
                     /translation="MKQTNTSIRLLTKISDYIKLMRIKQYIKNFFVFSAIIFSNNILN
                     INLFLNTFIAFVCFCLMSSSVYALNDAIDMDKDKKHPKKCNRPVASGRISKKSANILF
                     VVLALISVCLSTVVSFNLSIILSLYLINNILYSLKLKNIILLDVFSISLGFILRVYAG
                     CVAISVSLSNWIILCTFFLSLYLALGKRKKEIETLRDDAVEHRKILEDYDIENLNQMM
                     IVILSSTIVCYALYSTSNPEKPHMIFTTIFVVYGVLRYNYIINTTNENNPTDIVLKDN
                     ALKINVILWIITCLIILIF"
     gene            3816..4445
                     /locus_tag="KNP36_003529"
     CDS             3816..4445
                     /locus_tag="KNP36_003529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family hydrolase"
                     /protein_id="HBF0875357.1"
                     /translation="MKKSVLLLDVDYTVINTDSMIDFFIYSLKNKTFKTIIKLPYIIF
                     ILFMYLIRMIPLKKAKEAIFYPIVDFSEEDLKKFFDDCIMKKINESMKKVIYKNKEED
                     NVIIMITASPYAYMKYFKYYGLADEVIGTEFFYENSRYKNQFIGENCKGIEKVKRIKA
                     VLGKLGIEIDYENSYAYSDSKSDLPMLSLTKNAFLVSKKDGEVIEQINS"
     gene            4450..4914
                     /locus_tag="KNP36_003530"
     CDS             4450..4914
                     /locus_tag="KNP36_003530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="small multi-drug export protein"
                     /protein_id="HBF0875358.1"
                     /translation="MSLRIGGNSLGYLHILILSMVPVTELRGAIPIGIAMGLNPIWVY
                     VFSVIGSTLVSIPLILTFRHVLQFLRGKKLFKGIADVIDRKINSRMKKLKSVSIIGII
                     LFVGIPLPTTGTWTASAIASILKMRIKDAFMGVFLGNLLSGVIVSALSLHII"
     gene            5164..6531
                     /locus_tag="KNP36_003531"
     CDS             5164..6531
                     /locus_tag="KNP36_003531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HBF0875359.1"
                     /translation="MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGR
                     MENGEVAMAGVGVAFPIIIIITACSYLIGMGGGPLAAIKMGEQNNDEAEKIMSNSFSV
                     LVILAILLTIGFKIGKEPLLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFIN
                     TQGFATTGMMTVAIGALINIILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFG
                     KKSILKIKKKYMIPKASIILPVLGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGS
                     MAIMSSIMQILMLPNMGVTQGAQPIISYNYGSGQLDRVKKTFKLCLLSCFTYSTILWL
                     LLMIFPAFFVSIFNKNPQLLSMTSWSIKIYFAGAFMFGIQIACQQTFLALGKATISLV
                     LALLRKIVLLIPLIFILPTFFNEKLFAVILAEPVADITAATITAISFFIFYKCFLSKP
                     KAIKE"
BASE COUNT         2470 a          670 c         1088 g         2348 t
ORIGIN      
        1 taaaaaaaat attataccat aaataattta taaaaattat ttatggtata atattttcta
       61 taaagaaatt aagtcttaat atatctaagg aggaatttac aatgagatac gttgaatatg
      121 gaaagacagg gaaaatggtt tcagtagttg gctatggagg attaaggttt gatttagaaa
      181 aaagtaatca agaaaatgct gatttagtca aatatgcgta tgaaaaaggt attaattact
      241 ttgatacagc accagggtat tgtgatgaca gaagtgaaga tatatttgga ctagccttta
      301 gacaaatgat aaaggaaggt aagaccgatt tttatgtatc aactaaagaa aagccaaaag
      361 catgtgatac atcagaaaaa gctatagagg ctgtaaaaaa atcaatagaa cgattaggcg
      421 tatctaaaat aaatttttat catgtttgga atattagaaa gatggaacat tacgaactag
      481 caatgagacc tggaggtcaa tatgaaggat tattgaaatg taaagaagaa ggattgatag
      541 accatatagt attttcatct catcaaccag gagatgaggt tatagatatt ctaagtgaaa
      601 ataagtttga aggtgtaact atgggaataa atatattaaa ctttccatat aggctaaaag
      661 gtgccaaata tgctgttgat aatggatatg gtgttgtggc aatgaatcca ttaagtggtg
      721 gaactattcc aaagtataat aaagaacttt cttttctatc aaaagatggc gaaagtacta
      781 tagaatcagc tttaagattc aacataggaa tttcacaaat aagtatatct ttgatagggt
      841 ttaataaaaa acaagatata gatgatgcat gtaaaattgc agacgaaaat agaatttatt
      901 cagatgagga tatacatgat attgagacta gattaaataa gaatatgaac gaaatatgta
      961 caggttgtgg ttattgtaaa gtatgtccaa aaggtattaa taccccagcc tatatgcttt
     1021 tttataatga aaagcagatg tttaaaaaga gtgatgaaga aatgacaaag ttagtttatg
     1081 gcttaggaca ttggaattac acaatgaata gtaaggcaaa agctaaagaa tgtatatctt
     1141 gtggaaaatg tgaagttgaa tgtactcagc atttacctat aatagataga ttaaaagaaa
     1201 ttaaaaaatg ggaagaagat ggagctaata gtgttaaagt ctaattaatt ttatactata
     1261 tttgaaattt gtatagtatt tagtaatgtt ttaaaatata gttttaatat ttaaggagac
     1321 agattataat tttgtctcct taaattatgc tttaatttgt tatagtttaa ttccataagt
     1381 aacattgtat atttttatat aaagtttttc aaatatttta cattaatatt gcttacaaat
     1441 tctcatttta tacaacacta atctatgtta tataaacaat acttgactga ttataacatc
     1501 aataaagtaa atattgtggt tgtaaataaa gagttattca attacaataa aacaagtaag
     1561 aacattatga agatggctat taaatataag gaataaattg taggtgtcag caaatcctat
     1621 ataatgaatg gatggtgata tattgatgag taaaatatta aaatataaaa acgagatgtt
     1681 tttgtttata ttagttgtaa taacttactt aataataact aagatatttt tttctaagac
     1741 tactatattt tatgatttaa acaatactta tgatgtattg ttagatacag atacaggagt
     1801 tttattcaat ttaaatgtat ttgctataag tcaagacaat agtaagcata tattgttttc
     1861 agcaattata tcaatttttg catatccaat atacctattt tgtacttcaa tagcaaatcc
     1921 tgggacaaca gattttaata gtgcctatgg gtttggacta atttgtctac aaataataac
     1981 tagtgctatg tcaataactt tagtctttaa tcatattaaa aagataaaaa tgcagagatt
     2041 aactttaatt ttacttacta tgataatgat attttctttt ccacagttat ttatgacttt
     2101 aaatgtagag agatttatat atagccaatt ttcattaata tttttcatag ttattgcaaa
     2161 taagatgaaa ggaaaaaatt cttatttggt agaattagca gctattcctc tatttggaat
     2221 aactattagt aatatatatt tgtatttttt taatatgata tttgagttta aattaaaaat
     2281 aggaaaaatg ttaaaacatt taattacatt tatcctaatg gcatatattt gtgtagtttc
     2341 aacgaagtct tatgagagtt ttatgaacct tggaaatgta atacagtatg atacgaaatt
     2401 tataagtgga gaaccaattt tggaaaagat tgcaatgatt atagagagat tattgtattc
     2461 ggttttttat tttcctggag caagtattaa aaaagggtta tttttgcaaa atggagaagt
     2521 tgctacaata ccagtaattc ttacattatt agctttatgt ttttgtgttt tatcagttat
     2581 tgaaaattca gaaaaaagag ttcctaagct atgtatggga ataattatat tcaatctaac
     2641 tttacatggt atagtaggat ataatctagt caattcaagt attatggcta taaattttag
     2701 ttttgcagtt ataattttat tggcttactt tacgaaagcc cttagaaaaa atgaaaagaa
     2761 tatgtataat atatttctat cgctgttatt ggttactata gtaatcagta atgtcaatgg
     2821 atttatagaa attttaaaca tagggataaa atcatatcct gtttaaaaaa taatattgaa
     2881 agggtagtaa gtttatgaaa cagaccaata caagtataag gcttcttact aaaatttcag
     2941 attatataaa gttaatgaga ataaagcaat atataaagaa tttctttgta ttttcagcta
     3001 taattttttc aaacaacata ctaaatataa atttattttt aaatacgttt attgcgtttg
     3061 tgtgtttttg cctaatgtca tcatcagtat atgcactgaa tgatgctata gacatggata
     3121 aagataaaaa acatcctaaa aaatgtaata gaccagtggc aagtggaaga ataagcaaaa
     3181 aaagtgctaa tatactattt gtagtattag cgttaatttc agtctgttta tcaacagttg
     3241 ttagttttaa tctttctata attctcagtc tctatttgat aaacaatata ttatattctc
     3301 ttaaactaaa gaatataata ctattagatg tgttttcaat atctcttggt tttatactta
     3361 gggtttatgc aggatgtgta gccataagtg ttagtttatc aaattggata attttatgta
     3421 catttttctt atctctgtac ttagctcttg gaaaacgtaa aaaagaaata gaaactctaa
     3481 gagatgatgc agttgaacat agaaaaatat tggaagatta tgacatagaa aatctaaatc
     3541 aaatgatgat agttatatta agttctacaa ttgtatgtta tgcattgtat tctacaagta
     3601 atccagaaaa gccacatatg atatttacaa caatatttgt agtttatggt gtacttagat
     3661 ataattatat aattaacact acaaatgaaa ataatcctac tgatattgtc ctaaaagata
     3721 atgctttaaa aataaacgta atcttatgga taattacatg tttaataata ttgatttttt
     3781 agtgatattt ttagtgatag gatggggaaa tacttatgaa aaaaagtgta ttattacttg
     3841 atgtagatta tactgttata aatactgata gcatgataga tttttttatt tactctttaa
     3901 aaaataaaac ctttaaaact attataaagt tgccatacat tatttttatt ctatttatgt
     3961 atttaattag aatgataccc ttgaagaagg caaaagaggc aatcttttat ccaatagtag
     4021 attttagtga agaagattta aaaaagtttt ttgatgattg cataatgaaa aaaattaacg
     4081 aatctatgaa aaaggttatt tacaaaaata aagaagaaga taatgttata attatgataa
     4141 ctgcatctcc atatgcatat atgaaatatt ttaagtatta tggtcttgca gacgaggtta
     4201 taggcacgga gtttttttat gaaaattcaa gatataaaaa tcaattcatt ggagaaaact
     4261 gtaagggaat tgaaaaagta aaaagaataa aggctgtatt aggtaaactt gggatagaga
     4321 ttgattatga aaattcatat gcatattcag actctaagag tgatttacca atgctttcat
     4381 tgactaaaaa tgcattttta gttagtaaaa aggatggtga ggttatagag caaataaatt
     4441 cataacttaa tgtcacttag aataggaggg aatagtttgg gatatttaca catattaatt
     4501 ttatctatgg ttcctgtaac agaattgagg ggagccattc ctataggtat tgcaatgggc
     4561 ttaaatccta tatgggttta tgtatttagt gtaataggtt ctacattggt atcgattccc
     4621 ttgatattga cattcagaca tgtattacaa tttttaagag ggaagaaact atttaaaggg
     4681 attgctgatg taattgatag aaaaataaac tcaagaatga agaaattaaa aagtgtttcg
     4741 ataattggta taatactatt tgtaggtata ccactgccaa ctacaggaac atggactgca
     4801 tctgctatag cttccatatt aaaaatgaga ataaaagatg cttttatggg agtatttctt
     4861 ggcaatttgt tatcaggggt tatagtttca gctctttctt tacatataat ataaaactat
     4921 ctaagtaata tacttggata gtttttttat gagtatatgt gaaaaatttt taataataaa
     4981 taaaaaatga gataaagtat ttaacttcag ttagttctaa aatgtttact atggcaaaag
     5041 aaatatagta tagtattact tgtagggaaa gtactctaaa tttgtctgct aataaaatga
     5101 aatttttata tagaataaaa ttttagtgat acattttaat tattggattg aggaggtttt
     5161 aaaatggaaa attcaaacac taacttaggt agtgaaagtg tgggtaaatt attatttaaa
     5221 cttgctacac ctgctattat cgcacaaatt gtaaatgttt tatacaacat agtcgatagg
     5281 atttttattg gtagaatgga aaatggagaa gttgctatgg ctggtgttgg agtggcattt
     5341 ccaataataa ttataataac tgcatgtagt tatttaatcg gtatgggagg aggtccatta
     5401 gctgctataa aaatgggtga gcaaaacaat gatgaggcag agaaaataat gagtaacagt
     5461 ttttctgtat tggtgatttt agcaatactt ttgactatag gttttaagat tggaaaagag
     5521 cctttacttt ggatgtttgg agcaagtgaa tctacaattg gatattcaat ggactattta
     5581 aatatttatt taataggtac agtgtttgtt cagatttcaa tgggtatgaa tacttttata
     5641 aatacccaag ggtttgctac aactggaatg atgacagttg ctataggtgc tttaataaac
     5701 ataatacttg acccgatttt tatatttggc tttaatatgg gtgtaaaagg agctgcatta
     5761 gctactataa ttgcacaagg cgtttctgct atttgggtac ttatgtttct ctttggaaag
     5821 aaaagtatac ttaaaataaa aaagaagtat atgataccaa aagcaagtat catcttacca
     5881 gtgcttggct tgggaatctc tccatttata atgcaatcta cagaaagttt agtacttata
     5941 gccttaaata gtaaattaca aatgtatgga ggagatttag cagtaggttc aatggccata
     6001 atgagcagta taatgcaaat tcttatgctt cctaatatgg gggttacaca aggagcacaa
     6061 ccaataataa gttataatta tggttcaggt caacttgata gagtaaaaaa gacatttaag
     6121 ttgtgtttat tgtcatgttt tacatattct actattttat ggcttttatt aatgatattt
     6181 cctgcatttt ttgttagtat atttaataag aatccgcagt tacttagtat gactagttgg
     6241 agtataaaaa tatattttgc tggtgctttt atgtttggga ttcaaatagc ttgtcaacag
     6301 acatttttag cacttggaaa agcaacaata tctttggttt tagctctact tagaaagatt
     6361 gtacttttaa tacctttaat atttatactt ccaacattct ttaatgaaaa actttttgca
     6421 gtaattttag cagagccagt tgcagatata acagccgcta ctataacagc aatttctttc
     6481 tttatatttt ataaatgttt tctatcaaaa cctaaagcaa taaaagaata agatatacaa
     6541 tataaatttt ttatgaaaat attttattag ataaaa
//
LOCUS       DAEHWM010000149         6543 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.152, whole genome shotgun sequence.
ACCESSION   DAEHWM010000149 DAEHWM010000000
VERSION     DAEHWM010000149.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6543)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6543)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6543
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.152"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..1364)
                     /locus_tag="KNP36_003532"
     CDS             complement(<1..1364)
                     /locus_tag="KNP36_003532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UbiD family decarboxylase"
                     /protein_id="HBF0875360.1"
                     /translation="MNFRDLFEKAVDFIDEKRKSIVAISLSTLGVIALIIVFFLSSNE
                     FSVGNEANELLKIIEKRQYSIAVDYYTSIEKKFSDSKMERFNKSVSKKINKLLLNSGD
                     KYLDGDISQESFIGLINTVKELNKISIDVDDLLAQADRVREMYKEENTTYDIAINYIS
                     TVSILNGMGSNLDVYKQNIETIKESRDVYDSAVKDQKAYKYYEAIEKYNKVLKEDEKY
                     YSMAQNGKEQCIEEMYDYYISRAEEANTSGDYERALQYIEYLKDDYSDDEKVQSLEKK
                     YKKNLSLYTLTSDDIINVIAKKSGKDKANLSINSLPQMIKNNKYYYAEVYEYDKLINE
                     VLVSAKTKDLYSYKDGKKDYKVDYGDGYFRILEDGSYQFGITKDKAKFVLTNTLDEKE
                     NKYKKIEILDIEKADRYVKSKKSLEELFGKYKNIYYYAVVNKGLFRGKEVYAINIYNE
                     KIYA"
     gene            complement(1530..1778)
                     /locus_tag="KNP36_003533"
     CDS             complement(1530..1778)
                     /locus_tag="KNP36_003533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875361.1"
                     /translation="MMICFAMTFALVLINSVMGVHIGLDYYFLMGSVLTVCLTIGIVL
                     CNARKIFDSKAIHKTRTKTVSNNKKQKSHSRDIKRKIS"
     gene            2044..4173
                     /locus_tag="KNP36_003534"
     CDS             2044..4173
                     /locus_tag="KNP36_003534"
                     /EC_number="1.11.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxiredoxin"
                     /protein_id="HBF0875362.1"
                     /translation="MPNLPSLGSKAPDFKANTTNGPIRLSDYKGNWIVLFSHPGDFTP
                     VCTTEFLCFAKYYDEFKKRNTELIGLSVDSNSSHLAWMYNISLLTGVEIPFPIIEDRD
                     MRIAKLYGMISKPMSDTSTVRSVFIIDNNQILRTILYYPLTTGRNIPEILRIVDALQT
                     SDRDNIVTPANWFPGMPVILPYPKNYKELKNRVNSCNKKYSCMDWYLCFVPDNYNDEE
                     VSKKIDNTCSWKKEHTKNIENECNCEHEHHDYLNKALDCKQEHKTDIKDDCNHEKKHT
                     KNTNKVHNSKQDKFKDKSCDEMNFNYDKDESCDKINSSYNKEDSSYEDFYKHNYKNYD
                     YTSEKNTKKIAMKTLKDSKKLVRPQITDPYNPIVENANCPDINPIVAEYVLGNPTNVD
                     AQLLDAVIFAFAEIDQSGNLFIPYPRFLNQLLALKGEKPSLKVIVAIGGWGAEGFSDA
                     ALTPTSRYNFARQVNQMINEYALDGIDIDWEYPGSSASGITSRPQDRENFTLLLTAIR
                     DVIGDDKWLSVAGTGDRGYINSSAEIDKIAPIIDYFNLMSYDFTAGETGPNGRKHQAN
                     LFDSDLSLPGYSVDAMVRNLENAGMPSEKILLGIPFYGRLGATITRTYDELRRDYINK
                     NGYEYRFDNTAQVPYLVKDGDFAMSYDDALSIFLKTQYVLRNCLGGVFSWTSTYDQAN
                     ILARTMSIGINDPEVLKEELEGIYGQF"
     gene            complement(4400..4999)
                     /locus_tag="KNP36_003535"
     CDS             complement(4400..4999)
                     /locus_tag="KNP36_003535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease H family protein"
                     /protein_id="HBF0875363.1"
                     /translation="MAKQKFYAVKKGKNIGVYNTWDECKKQVNGFSGAEYKSFSTFQE
                     AKEYIDGSEKLSFQEDKEFIEAYVDGSYEHSVKMYGSGVVILKNNEVIKTYSEKGKEK
                     TLVSMRNVAGEIEASKIAMQYCIDNNVQNLILYFDYEGIEKWCTGVWKTNKEGTIAYK
                     NFYDSIKNKLNVKFTKVKAHSGNKYNEEADKLAKKAIGV"
     gene            complement(5017..>6543)
                     /locus_tag="KNP36_003536"
     CDS             complement(5017..>6543)
                     /locus_tag="KNP36_003536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease"
                     /protein_id="HBF0875364.1"
                     /translation="KAFDKFYNVLKIGREDKQKIARSINFIIEEIDSILKFGNCNEYN
                     NVSNYNLRWELNLQIDEIVGKLKKDGIDTEISYRAYSEKIKLSCEKIIKNLVSIIIII
                     YRNIDDDSIDKEADIYKFGKAKTRDLEDIKIIFEIFLEYDEKDDYARIVEIDKNYNDF
                     EFRVVPLKIADLFEENILSQLEKGIFLSATLSLSESMSYFKNTLGIDRVKNVEKIIEP
                     IFDYKNRVSVVGFSDICEYRNSEFPNEMSKIISNISKITEGHTLALFNSKDRQEKTYE
                     ILKKYLHSFNLEIYADKKGIRHLNDLNRKCVVLGSKGCFEGVDIPGDGLVCVTLDKLP
                     NLNPKDPLYFTIMKKYGIDYYTINYPQMTIKVKQAMGRILRSKYDYGCFVIFDVGTNI
                     SVLKRLEKDLHDCKISKVNSNEFYTYIRRHLNKSRSLILKSVIFDTIKALNVDAKMDN
                     NDVDKDIIKKDINENIRQRAVKGEVYHIDIIKKDMKVKYFDRNYLINLDIFMREEDKN
                     "
BASE COUNT         2248 a         1053 c          701 g         2541 t
ORIGIN      
        1 atggcatata ttttttcatt gtaaatatta atagcataaa cttctttgcc tctaaataag
       61 cctttattta ctacagcata ataataaata tttttatatt ttccaaacaa ttcttctaaa
      121 ctctttttac tttttacata tctatctgct ttctctatat ctaatatctc aatcttttta
      181 tacttatttt ctttttcatc aagagtatta gttaacacaa acttagcttt atcttttgta
      241 ataccaaatt gataacttcc atcttctaat attctaaagt atccatcacc ataatctact
      301 ttgtaatctt ttttaccatc tttatatgaa tataaatctt tagtttttgc acttaccaaa
      361 acttcattta ttaatttatc atactcatat acttcagcat aatagtattt attatttttt
      421 atcatttgtg gaagtgaatt tatagataga tttgccttgt ctttgccact ttttttagct
      481 attacattta taatgtcatc agatgttaaa gtatacaatg ataaattctt tttatatttt
      541 ttttctaaac tctgtacctt ttcatcatct gaataatcgt cttttaaata ctcaatatat
      601 tgtaatgctc tttcataatc tccagaagta tttgcctctt cagctctact tatatagtaa
      661 tcatacattt cttcaataca ttgttctttc ccattttgag ccatactgta atacttttca
      721 tcttctttta atactttatt atacttttca atagcttcat aatacttata tgctttttgg
      781 tcttttactg ctgagtcata aacatctcta gactctttga ttgtttctat attctgtttg
      841 tatacatcta ggttactacc cataccattt aatattgaaa cagtacttat gtagttaatg
      901 gcaatatcat aagtagtatt ttcttcttta tacatttctc taactctatc agcttgagct
      961 aataagtcat ccacatctat acttattttg tttaattctt tcacggtatt tattaatcca
     1021 ataaaacttt cttgacttat gtctccatct aaatatttat caccactatt taatagcaat
     1081 ttatttattt ttttagaaac agacttatta aacctttcca tttttgaatc agaaaacttt
     1141 ttttctatac ttgtgtagta atcaacagct atagaatact gtcttttctc tataatcttt
     1201 aacaactcat tagcttcatt tcctacacta aactcgttac tacttaagaa aaatactatt
     1261 atcaaagcaa ttacacctaa tgttgataat gaaatcgcaa ctatagattt ccttttttca
     1321 tcaataaaat ctacagcctt ctcaaataaa tctctaaaat tcattatagt tccctctcca
     1381 tttaataatc tttatatttt atggtaaact aaatttctta ttggttatta tatcataatt
     1441 cttgaaaaaa aataaaaaca caagttaaat cgtgttttta ttttacctat caatcattat
     1501 tttatacata aatatttcct ttacataaat tatgatatct ttctttttat atccctagaa
     1561 tgactctttt gttttttatt attactgaca gttttcgttc ttgtcttgtg tatagctttg
     1621 ctatcaaata tttttctagc attgcataaa acaattccaa ttgttaaaca aactgtaagc
     1681 acacttccca tcaaaaagta ataatccaat cctatatgta ctcccataac tgaatttatt
     1741 aacactaatg caaaagtcat tgcaaaacat atcatcatgg agataactaa aattcttaga
     1801 atttttttca atccactcac ctcgtataat cactaaaatt gacactaccc cttatccatt
     1861 actataccaa attagtaaaa aaatagcaat tactattgtc atttatatta ggaaaatatt
     1921 aaatcttttt aataaatatc tttttttgac ataaggatta cttaactttt aataaaatag
     1981 taacactaat atgtattaat taatagaata aaataaatga taatttattg aggggtgatt
     2041 tacatgccaa atttgccaag tttagggtca aaggctcctg attttaaagc caatacaaca
     2101 aatggtccta ttagactctc tgactataag ggtaattgga ttgttttatt ttcacatcct
     2161 ggtgatttta caccagtttg tactacagaa tttttatgtt ttgctaaata ttatgacgaa
     2221 tttaaaaaaa gaaatacaga actaattggt ctaagtgttg atagtaacag ttcacattta
     2281 gcttggatgt ataatatttc tttacttaca ggtgtagaaa ttccatttcc tattatagaa
     2341 gatagagata tgagaattgc caagttatac ggcatgatat caaaaccaat gagtgataca
     2401 tcaactgttc gctctgtatt tattatagat aataatcaaa ttctaagaac gattctttat
     2461 tatccactaa ctacaggaag aaatattcca gaaatactta gaatagtaga tgcacttcag
     2521 actagtgata gagataatat agttactcct gcaaactggt ttcctggaat gccagtgatt
     2581 ttaccttatc ctaaaaacta taaggaatta aaaaatagag ttaacagttg taataagaaa
     2641 tattcatgta tggactggta cttatgtttt gtaccagata attataatga tgaagaagtg
     2701 agcaagaaaa ttgataatac ttgtagctgg aaaaaagaac atactaaaaa cattgaaaat
     2761 gaatgtaact gtgaacatga acatcatgac tacctgaaca aagctcttga ctgtaaacaa
     2821 gaacacaaga ctgatattaa agatgattgc aatcatgaga aaaaacatac taaaaatact
     2881 aacaaagttc acaactccaa acaagataag tttaaagata agtcttgtga tgaaatgaat
     2941 tttaactatg ataaagatga atcttgtgac aaaataaatt ctagctataa caaagaagat
     3001 agtagttatg aagatttcta taaacataat tataaaaact acgattatac tagcgaaaaa
     3061 aatactaaaa aaatagctat gaaaacttta aaagattcta aaaaattagt tagaccacaa
     3121 ataacagacc catacaatcc aatagttgaa aatgcaaact gtccagatat aaatccaatt
     3181 gtagcagaat atgttcttgg aaatccaact aatgtagatg ctcaactatt agatgcagtt
     3241 atatttgctt ttgctgagat agaccagtct ggaaatttgt ttattcctta tcctagattt
     3301 ttaaatcaat tacttgctct taaaggtgaa aaacctagct taaaagtaat tgtagctatt
     3361 ggaggttggg gagctgaagg attctctgat gcagcattaa cacctacatc tagatataat
     3421 tttgcaagac aggtcaatca gatgataaat gaatatgctt tagatggaat agatatagac
     3481 tgggaatatc ctggaagtag tgcatctgga ataacatcaa gacctcaaga tagagaaaac
     3541 tttacactct tactaactgc cataagagat gttataggag atgataaatg gcttagtgta
     3601 gctggaacag gagatagagg atatataaat tcaagtgctg aaatagataa aatagctcct
     3661 ataatagatt attttaatct tatgagttat gattttacag caggtgaaac aggcccaaat
     3721 ggtagaaaac atcaagcaaa tctttttgat tcagacttat ctttgccagg atatagtgtt
     3781 gatgcaatgg taagaaatct tgagaatgct ggaatgcctt ctgaaaaaat ccttcttggt
     3841 ataccatttt atggaagatt aggtgctact ataacaagaa cttatgatga gcttagaagg
     3901 gattatataa ataaaaatgg atatgaatat agatttgata atactgctca agttccgtat
     3961 ttagttaagg atggagattt tgcaatgtca tatgatgatg ctttatcaat attcttaaaa
     4021 actcaatatg ttcttagaaa ttgtctaggt ggtgtattct catggacatc aacttatgac
     4081 caagcaaata tactggctag aaccatgtct attggtataa atgaccctga agtattaaaa
     4141 gaagaacttg aaggtattta tgggcaattc taatagaatg tagtaaaatt ttatagttat
     4201 ataaaaagca gattttatta tattaaataa gttgtatcta attaatacta ttattaattg
     4261 tttataaatt agatacttat tttttcataa tacaatctgc ttttttaatc aaaatttatt
     4321 taattacaag ttgtttaatt ataaagtagg aatttagata tactcttata ccatgtaatt
     4381 atgtataaat atttttttat tatacaccaa tagctttttt agctaattta tcagcttcct
     4441 cattatactt atttccagaa tgagctttaa cctttgtaaa ttttacatta agcttattct
     4501 taatactgtc atagaaattt ttatatgcta tagttccttc tttatttgtt ttccaaactc
     4561 cagtacacca cttttcaatc ccttcatagt caaagtataa aatcaagttt tgaacattat
     4621 tgtcaataca gtactgcatt gcaattttag aagcctctat ctctccagct acatttctca
     4681 tacttactaa agttttctct tttccttttt cactataagt ttttataact tcattatttt
     4741 ttaaaatcac aacacccgaa ccatacattt ttactgaatg ttcataactt ccatctacat
     4801 atgcttctat aaactcctta tcttcttgaa aactcaattt ttctgaccca tcaatatatt
     4861 ctttagcttc ttgaaaagta gaaaaactct tatattcagc tcctgagaat ccatttactt
     4921 gttttttgca ctcatcccat gtattatata cacctatatt tttacctttt ttcacagcat
     4981 aaaacttttg ttttgccaaa tatatcactc ccactcttaa tttttatctt cttctctcat
     5041 aaatatatct aaatttataa gatagtttct atcaaaatat tttactttca tatctttttt
     5101 tataatatca atatggtaca cttctccttt tacagctctt tgtcttatat tttcatttat
     5161 atcttttttt ataatatcct tatcaacatc attgttatcc attttagcat caacattcaa
     5221 cgcttttata gtatcaaata taacagattt tagtattaaa cttctagatt tatttaaatg
     5281 tcgccttata taagtataaa actcattgct attaaccttt gaaattttac aatcgtgtaa
     5341 atctttctct aatctcttta acacacttat attagttcct acatcaaaaa tcacaaaaca
     5401 tccatagtca tatttgcttc ttaaaattct ccccatagct tgctttacct ttatggtcat
     5461 ttgaggataa tttatagtat agtagtctat accatacttc ttcattatag taaaatacaa
     5521 agggtcttta ggatttagat tcggaagctt gtctaaagtt acacaaacca aaccatcccc
     5581 tggaatgtct acgccttcaa aacatccttt tgagccaagt actacacatt ttctatttaa
     5641 atcgttaagg tgtctaatgc cctttttatc agcataaatt tctaagttaa aactatgtaa
     5701 gtattttttc aatatttcat aagttttttc ttgtctatct ttactattaa aaagagctaa
     5761 tgtatgacct tctgtaatct ttgatatatt agatataatt ttactcatct catttggaaa
     5821 ttcagaattt ctgtactcac aaatatcaga aaatccaact acagagactc tatttttata
     5881 atcaaaaatt ggttctataa tcttttccac attcttaact ctgtctattc ctaatgtatt
     5941 tttaaaataa gacatacttt cagataaact caaagttgct gataaaaata ttcctttttc
     6001 taattgagat aaaatatttt cttcaaataa atctgctatt tttaatggta ctactcgaaa
     6061 ttcaaagtca ttataattct tatcaatttc aactatcctt gcataatcat ccttttcatc
     6121 atactctaaa aagatttcaa atataatctt tatatcctct aaatctcttg tctttgcctt
     6181 tccaaattta tatatatctg cttctttatc tatactatca tcatcaatat tcctataaat
     6241 tattattatt attgaaacta aattttttat tattttctca caactcaact ttatcttttc
     6301 actataggct ctataactta tttcagtatc tataccatct ttttttagtt ttcccacaat
     6361 ttcatctatt tgcaaattca gttcccatct taaattataa ttacttacat tattatattc
     6421 attacaatta ccaaacttta atattgaatc tatctcttca ataatgaaat ttatacttct
     6481 agcaattttt tgtttatctt ctcttccaat ttttaataca ttataaaatt tatcaaaagc
     6541 ctt
//
LOCUS       DAEHWM010000150         6184 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.153, whole genome shotgun sequence.
ACCESSION   DAEHWM010000150 DAEHWM010000000
VERSION     DAEHWM010000150.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6184)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6184)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6184
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.153"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            103..1047
                     /locus_tag="KNP36_003537"
     CDS             103..1047
                     /locus_tag="KNP36_003537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP phosphoribosyltransferase regulatory
                     subunit"
                     /protein_id="HBF0875365.1"
                     /translation="MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYD
                     EFTTINNKIPEESMVKVVNGKVMVLRADITTSIIKSLVPRWEDGLKLKLFYNSSIYKN
                     KNTVGIKEIRQIGCEYLGEASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLE
                     ELNLNKNCENQIKNLLYTKNTHELKVYIEELKIKREVKELLSNILSLQGNLYNVIEKS
                     NKFYCNNKMKQALEELKQVNNLIEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSY
                     KEILSGGRYDSLTKEYGKEIPAIGFTLSVDELMKYVYK"
     gene            1069..1695
                     /locus_tag="KNP36_003538"
     CDS             1069..1695
                     /locus_tag="KNP36_003538"
                     /EC_number="2.4.2.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP phosphoribosyltransferase"
                     /protein_id="HBF0875366.1"
                     /translation="MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEEN
                     KIIYIHVKPSDVVTYVEKGVADLGIAGKDTILENETDVYEIYDLGFGKCKFAVAGLKG
                     DSIYREDEYLKVATKYPNIAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVET
                     GNTLKANGLEILEDICNISARIISNRASYRFKYEQIQNIIRLFEELDN"
     gene            1729..2778
                     /gene="hisC"
                     /locus_tag="KNP36_003539"
     CDS             1729..2778
                     /gene="hisC"
                     /locus_tag="KNP36_003539"
                     /EC_number="2.6.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidinol-phosphate transaminase"
                     /protein_id="HBF0875367.1"
                     /translation="MREKESIRELRGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDS
                     DIDLNLYPEDSYSDLKESIIDYINISGVNKKNLLVGNGSSEIIDLIIHTFVDKDEVIL
                     SFSPSFSMYSIYSQINGSKFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTG
                     TILKREEIIKLLDSTNSLVVLDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGI
                     RTGYMLSNSSLINSVEKVRPPYNLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYE
                     EMIGMGIKAYKSQANFILFYSEIENLSQKLIDRGVLIRKFGGKLENYYRVTIGDKEEN
                     SMFVGAIRDILKKEK"
     gene            2781..3359
                     /gene="hisB"
                     /locus_tag="KNP36_003540"
     CDS             2781..3359
                     /gene="hisB"
                     /locus_tag="KNP36_003540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazoleglycerol-phosphate dehydratase HisB"
                     /protein_id="HBF0875368.1"
                     /translation="MRIWKVERNTLETQILVELNIDGSGKAEIDTGIGFLDHMLTLMS
                     FHGKFDLKVICKGDTYVDDHHSVEDIGIAIGEAFKNALGDKKGIRRYSNIYIPMDESL
                     SMVAIDISNRPYLVFNAKFDTQMIGSMSTQCFKEFFRAFVNESRVTLHINLLYGENDH
                     HKIESIFKAFARALKEGSEIVSNEIASSKGVL"
     gene            3361..3966
                     /gene="hisH"
                     /locus_tag="KNP36_003541"
     CDS             3361..3966
                     /gene="hisH"
                     /locus_tag="KNP36_003541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazole glycerol phosphate synthase subunit
                     HisH"
                     /protein_id="HBF0875369.1"
                     /translation="MNIIVDYGLGNIDSVSRGFRKAGIETKISSDIDEIKQADSLILP
                     GVGAFRDSISALDKLGLIPIIKEHVSKGKFMIGICLGMQLLYEKSYEYGEYEGLGLIK
                     GSIDKLDISLKVPHMGWNNLKFNKANDDILKYINEDDYVYFVHSYYANSSNEELIAFS
                     EYEKKIPAIVRKGNVYGIQFHPEKSGEVGLNILRAYGEMIK"
     gene            3963..4685
                     /gene="hisA"
                     /locus_tag="KNP36_003542"
     CDS             3963..4685
                     /gene="hisA"
                     /locus_tag="KNP36_003542"
                     /EC_number="5.3.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase"
                     /protein_id="HBF0875370.1"
                     /translation="MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGA
                     EYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVIL
                     GSIAIENLNLVEELVNEYKEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGV
                     QTIVYTDISKDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAII
                     GKALYDKKIDFKEAQQLCLLGE"
     gene            4667..5425
                     /gene="hisF"
                     /locus_tag="KNP36_003543"
     CDS             4667..5425
                     /gene="hisF"
                     /locus_tag="KNP36_003543"
                     /EC_number="4.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000880088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="HBF0875371.1"
                     /translation="MLTRRIIPCLDVRNGRVVKGKKFKDIVDVDSPEVLGKFYSDCGA
                     DELVFYDITASNEERKTSLEFVTKVAENINIPFCVGGGVNKLEDFTDILRKGADKVSI
                     NSSAVKNPELIREASLKFGAQCVVLSIDAKKNEEGSWSVYVKGGREKTNLDAIEWAVK
                     GVELGAGEIVVNSMDEDGMKNGYDIELLSKITSLVNVPVIASGGAGKKEDFYEAVNKS
                     NVDGILAASVFHFGEIKINDLKKYLKDMGVEVRL"
     gene            5453..6121
                     /locus_tag="KNP36_003544"
     CDS             5453..6121
                     /locus_tag="KNP36_003544"
                     /EC_number="3.5.4.19"
                     /EC_number="3.6.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional phosphoribosyl-AMP
                     cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE"
                     /protein_id="HBF0875372.1"
                     /translation="MDNKCNNVYSDEVEKFIRSIKFDDKGLVPVVVQEVVSKDVLMLA
                     YMNKDVIKKTLKDKVACYFSRSRQELWVKGETSGNTQKVVKMSYDCDVDTILLFVEQT
                     GVACHTGNYSCFYRDLFDDSSKMELEVQTNILKELYDLINERKNNPVEGSYTNYLFEK
                     GIDKILKKVGEESSEVIIASKNTDKSELIYEISDLVYHTLVLMIEKGVEIDEIKKELL
                     KRRK"
BASE COUNT         2527 a          521 c         1229 g         1907 t
ORIGIN      
        1 tttaagagaa aattatagcc atataggtat aaagcctatg tggctttttt attgttttaa
       61 atttgcaaat ataagagtaa atttaatgaa gagggtgaga atgtgaaatt tttgaggatt
      121 gaagatgagg ttatttattc taaaaaaaga tataaattaa aaagggaaat agataaactt
      181 tttttggatg aagaatattt tcaaatagaa ccacaattat ttgaagaata tgatgaattt
      241 acaactataa ataataaaat tccagaagaa tctatggtaa aggttgtaaa tggaaaagta
      301 atggtactta gagctgatat aactacaagt ataataaaaa gccttgtacc aagatgggaa
      361 gatggtttaa agcttaagct tttttataat tcatcaatat ataaaaataa aaatacagtt
      421 ggaataaaag agataagaca aataggttgt gagtatctag gagaagcctc tgtagaagca
      481 gatagagaag tagtgaaatt agctcttaag atacttgaaa aatacaataa taattttatt
      541 ctagaggttg ggagtagcaa gtatattcat ggtttgttag aagaattaaa tttaaataag
      601 aattgtgaaa atcaaattaa aaatttacta tatacgaaga acactcatga actaaaagta
      661 tatattgaag aattaaaaat taagcgtgaa gtaaaagagt tattatcaaa tattttaagt
      721 ttacaaggga atttatataa tgttattgaa aaatcaaaca agttctattg taataataag
      781 atgaagcaag ctcttgaaga attaaagcaa gtaaataatt taattgagga atgtaatttt
      841 ttagataagg ctagatttga tttatcaatg attactatgc ttgactatta tgaaggaatt
      901 atgtttagag gatactaccc aaactcatat aaagaaattc ttagtggcgg aagatatgat
      961 tctttaacta aagagtatgg aaaagaaatt ccagccattg gatttacact aagtgttgat
     1021 gagttaatga agtatgtata taagtaaagt ttagaaggag ggattgcttt ggattatttg
     1081 actatagcac tagcaaaagg acgaattgaa ggggaatcat ttaaaaaatt taaaaaaatg
     1141 ggtctaggag acagtataga cacagatacg agaaaactaa tttttaaaga tgaagaaaat
     1201 aaaattatat atatacatgt aaagccatca gatgtagtta catatgttga aaaaggagtc
     1261 gctgacctcg gtatagcagg taaagatact attttagaaa atgagacaga tgtatatgaa
     1321 atatatgatt taggttttgg aaaatgtaaa tttgctgtag caggattaaa gggagatagc
     1381 atatatagag aagatgaata tttaaaagtg gcaacaaagt atcccaatat agcaaaaaag
     1441 tattttaaag agaaaggtca aaaaattgaa ataataaaat taaatggttc tgtagaacta
     1501 gctccaatag tagggttgtc agatgtaatt gtagatatag ttgagactgg caatacactt
     1561 aaagcaaatg gtcttgaaat attagaagac atatgtaata taagtgctag aattatatca
     1621 aatagagcta gctatagatt taaatatgaa caaattcaga atataattcg tttatttgaa
     1681 gaacttgata attaaaatat aattgagctt tataaggagg gatttaagtt gagagaaaaa
     1741 gaaagcataa gagagttaag gggatatgaa ccaaatcacg taaactgtaa agtaaaactt
     1801 gatgcaaatg aaggaagtaa gaggttgttt aaatacctta ttaaagaaat ttcagatagt
     1861 gatatagatt taaatttata tcctgaagat tcttatagtg atttgaaaga atctataata
     1921 gattacataa atatttctgg agtaaataag aaaaatcttc tagtaggaaa cggttcaagt
     1981 gaaataattg atttaataat acatactttt gtagataaag atgaagtaat attgagtttc
     2041 tctccaagtt ttagtatgta ttctatatat agtcagataa atgggtctaa atttataggt
     2101 gttgaaagtg atgaaaattt agttataaat atagataatg tgattgaaaa agtaaaggag
     2161 aataatccta aaatagtaat tgtatgtaat cctaataatc caactggaac aatattaaag
     2221 agggaagaga taataaagct tttagattca actaatagtc tagtggtttt agatgaagca
     2281 tatatggatt ttggagaaga aagcatgtta agtgatgttt ttaagtatga taatctaata
     2341 gttcttagaa ctttatcaaa ggcatttgga ttggctggaa taagaacagg atatatgtta
     2401 tctaatagta gtttaataaa ttctgttgag aaagtaagac ctccatataa tttaaattca
     2461 ttatcagact ttattgctac aagagcactt agaaataaag atgtggtaaa ggcttatata
     2521 aaggaagtaa aagaggaaag agaagtttta tatgaagaaa tgattggtat gggaattaaa
     2581 gcatacaaat cacaagcaaa ttttatatta ttttattctg aaatcgaaaa tttatcacaa
     2641 aaacttattg atagaggtgt tttaataaga aaatttggtg gaaagttaga aaattattac
     2701 agagttacaa ttggtgataa agaagaaaat tctatgtttg ttggagctat aagagatatt
     2761 ttgaaaaagg agaaataggt atgagaattt ggaaggtaga aagaaatact cttgaaacac
     2821 agattttagt agaattaaat attgatggtt ctggtaaagc tgaaatagat actggaatag
     2881 gatttttaga ccatatgctt accttaatgt catttcatgg caagttcgat ttaaaagtga
     2941 tttgtaaggg tgatacatat gtagatgacc accatagtgt agaagatata ggtatagcta
     3001 taggtgaagc atttaaaaat gcactaggtg acaaaaaagg aatacgaaga tattctaata
     3061 tctatatacc tatggatgaa tctctatcaa tggtagcaat agatataagc aatagacctt
     3121 atcttgtatt taatgctaaa tttgataccc aaatgattgg tagtatgagt actcaatgct
     3181 ttaaagaatt ttttagagct tttgtaaatg aatcgagagt aacattacat atcaatctct
     3241 tatatgggga aaatgaccat cataagatag aaagtatttt taaagcattt gcaagagctt
     3301 taaaagaggg tagtgaaata gtttctaatg agatagcatc ttcaaagggg gttttgtaga
     3361 atgaatataa tagtagacta tggtcttgga aatatagatt ctgtgtctag gggttttaga
     3421 aaagctggaa tagaaactaa aatttctagt gatatagatg aaataaaaca ggcagattca
     3481 cttatacttc caggtgttgg agcttttaga gattctataa gtgccttaga taaactagga
     3541 ttgataccaa taataaagga gcatgtttct aagggtaaat ttatgatagg tatatgtcta
     3601 ggaatgcaat tactttatga aaaaagttat gagtatggag aatatgaagg attaggactt
     3661 ataaaaggaa gtattgataa actggatata agtttaaaag tgccacatat gggatggaat
     3721 aatctaaaat ttaataaggc aaatgatgat atacttaaat atataaatga agatgattat
     3781 gtatacttcg ttcactcata ttatgcaaat tcatcaaatg aagaactaat tgcattttca
     3841 gaatatgaaa agaaaatccc tgctattgtt agaaaaggca atgtatatgg tatacaattt
     3901 catcctgaaa aaagtggaga agtagggtta aatatattaa gagcatatgg ggagatgata
     3961 aaatgataat atttccagca atagatataa aagataataa gtgtgtaaga ctcacacaag
     4021 gagaatttga caaagtaaat gtatattatg ataatccatt agaagtagca tataaatgga
     4081 aaaatgaagg agcagaatat atacatatag tagatttaaa tggtgctaga agtgaatttg
     4141 gtgtaaatac aaaaataatt gaggacatag caaacaatat agatatacct attcaagttg
     4201 gcggtggagt tagggataag gaaaaagtca aaagtttaat aaatgctggt gttactagag
     4261 taatattagg tagtatagcg attgaaaatt tgaatttagt tgaagaattg gtcaatgaat
     4321 ataaagagaa aattgtagtt tctatagatg ctaaagatgg aaaagtagca gttaggggat
     4381 gggaagttgt aagcaatgta gactcattaa cattatgtaa acaacttgaa aagataggtg
     4441 tacaaactat tgtttataca gatatatcaa aagatgggat gttgcaaggt ccaaattttg
     4501 acatatatga aagaatagca aaggaaacat cactaaatgt tattgcttct ggaggcgtaa
     4561 cttctataga agacgtaaaa agactaaaag ctatgaactt atatggtgca ataataggta
     4621 aagcgcttta tgataaaaag atagacttta aggaggcaca acaattatgc ttactaggag
     4681 aataatacct tgtctagatg tgagaaatgg aagagttgta aaggggaaaa aatttaaaga
     4741 tatagtagat gttgatagtc cagaagtact tggaaaattt tatagtgatt gtggtgcaga
     4801 tgaacttgta ttctatgata taactgcatc aaatgaagag agaaagacat ctttagaatt
     4861 tgtgacaaaa gttgcagaaa atataaatat accattttgt gttggtggag gagtaaataa
     4921 attagaagat ttcactgata ttttaagaaa aggtgctgat aaagtttcta taaattcatc
     4981 agcagtcaaa aatcctgaat taataaggga agcttcatta aaatttggag cacaatgtgt
     5041 tgttttatcg atagatgcaa agaaaaatga agagggttca tggagcgtat acgtaaaagg
     5101 tggaagagaa aaaactaatc tggatgcaat tgaatgggct gttaaaggtg tagaacttgg
     5161 agcaggagaa atcgttgtaa atagtatgga tgaagatgga atgaaaaatg gatatgatat
     5221 agaattatta tcaaagataa cttctttagt aaatgtacct gttatagcat ctggaggcgc
     5281 tggaaaaaag gaagattttt atgaggcggt taataaatcc aatgtagatg gaattttagc
     5341 agcatctgtt tttcattttg gcgagataaa aataaacgat ttaaagaaat atttaaaaga
     5401 catgggtgta gaagtaagat tataagttaa atactaaaag gagattagaa atatggataa
     5461 taagtgtaac aatgtataca gtgatgaagt agagaaattt ataagaagta taaagtttga
     5521 tgataaaggg ttagtccctg ttgttgttca agaggtagtt agcaaagatg tactgatgtt
     5581 agcatatatg aataaagatg tgataaagaa aaccttaaaa gataaagtag cttgctattt
     5641 tagtagaagt agacaagaac tttgggttaa aggtgagaca tctggtaata ctcaaaaagt
     5701 agttaagatg tcttatgatt gtgatgtaga tactatacta ctttttgttg aacaaactgg
     5761 tgtagcttgt catacaggca attattcttg tttttacaga gacttgtttg atgatagttc
     5821 aaaaatggag cttgaagtac aaacaaatat attgaaagaa ttatatgatt taatcaatga
     5881 aagaaaaaat aatccagttg aaggttctta tactaattat ctttttgaaa aaggaataga
     5941 taagattctt aaaaaagtag gtgaagagag tagtgaggta attatagcat caaaaaatac
     6001 tgataaaagt gaacttattt acgaaattag cgatttagta tatcatacat tggttttaat
     6061 gatagaaaaa ggtgttgaaa ttgatgaaat aaaaaaagaa ttacttaaaa gaagaaaata
     6121 gaataagata gattaatggg taataagaaa atataccact tttaataaaa agtggtatat
     6181 tttt
//
LOCUS       DAEHWM010000151         6015 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.154, whole genome shotgun sequence.
ACCESSION   DAEHWM010000151 DAEHWM010000000
VERSION     DAEHWM010000151.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 6015)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6015)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6015
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.154"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            94..441
                     /locus_tag="KNP36_003545"
     CDS             94..441
                     /locus_tag="KNP36_003545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861374.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBF0875373.1"
                     /translation="MHENKKNLLDGSLAQYNDTAVPKIPVFAGNDITSEVYYFKPNQV
                     LNAHRHPNGEQIFVFLKGEGKMKLGEHECDVKNGDTVFVPTGEWHEITNGSNEEMVAV
                     QITKINAGAEYRG"
     gene            complement(591..1091)
                     /locus_tag="KNP36_003546"
                     /pseudo
     CDS             complement(591..1091)
                     /locus_tag="KNP36_003546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897038.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            complement(1118..2623)
                     /locus_tag="KNP36_003547"
     CDS             complement(1118..2623)
                     /locus_tag="KNP36_003547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HBF0875374.1"
                     /translation="MNVAIYLRKSRADEEAEHRGEFETLSRHKTTLLKLAREQNLNVI
                     EIKEELVSGESIEYRPKMLELLGEIKNNNYDAVLVMDIDRLGRGNMQDQGLILDTFKK
                     SKTKIITPRKTYDLNDEFDEEYSEFEAFMARKELKLISRRMQRGKIKSIEEGKFIAQA
                     PPYGYDIKYLNNKERVLVINEDKATVVKIIFDMYLKGDGACKISNYLNELGYKTTTGR
                     TWYEKGIRDIIKNKVYCGYIVWNKVERKRNSSRTRGIEEQIEVKGKHEPIISEDIWNK
                     AQNIRKKRINSPTPNNKITNPLAGIVKCGYCNHTLIAKSNTTSNGYEKYMVCTNCKNK
                     ATKLYILENKILEVLNKWLVNYRLSLKDEKDNSKPENTLEHTLINLNKELDTLEKQKE
                     RLHDFLEQGIYDSNTFGERLKILLSRIENAREAINKTNIDIEMQKERNTVKTQIVPQL
                     EKILSEYTEEKEPYLKNILLKSVINYAVYKKEPNQKSDDFSLILYPNIPRD"
     gene            complement(2822..3676)
                     /locus_tag="KNP36_003548"
     CDS             complement(2822..3676)
                     /locus_tag="KNP36_003548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0875375.1"
                     /translation="MEWIERLNKAINYIEENITKEIEYEQVAKIACCSTYHFQRMFAY
                     MADVPLSEYIRRRRMSLAAVELQNDDKKIIDVALKYGYSSPTAFNRAFKSIHGVAPSV
                     IKKREITTLKAFPPISFKISIKGAEEMNYRIEKKEAFRIVGVSQPLHNELEKNFEIVP
                     QMWQKVALDGTLQKLIPMMDSQLQGVLGISICNNSEEWKYFISVSSTKSIDNTLEEYT
                     VPAFTWAIFSGEGQCPQAIQELEKRIVTEWLPTSGYEYDNGPDIELYLNPDPQNAKFE
                     VWIPVVKK"
     gene            4061..4342
                     /locus_tag="KNP36_003549"
     CDS             4061..4342
                     /locus_tag="KNP36_003549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875376.1"
                     /translation="MPNIEKDLDGTTTITYLNDDIGVPTDENGYKISMTILHGKTICH
                     VVSPETILGRKFTLEEKQEKDTIIYGAIEKIMVDRQLQIKNSNKEVASH"
     gene            4492..5340
                     /locus_tag="KNP36_003550"
     CDS             4492..5340
                     /locus_tag="KNP36_003550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003442793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sialate O-acetylesterase"
                     /protein_id="HBF0875377.1"
                     /translation="MIKSFLMLGQSNMAGRGFISEVTPIYNERIQMLRNGRWQMMTEP
                     INYDRPVSGVSLAASFADAWCCENQEDRIGLIPCAEGGSSLDEWNIDGILFKHAISEA
                     KFAIQSSELTGILWHQGENDSNNGNYKFYYKKLLSIIETLRKELNIPDIPIIIGGLGD
                     FLGKVGFGKSCTEYVFINQELQKFAFEQDNCYFVTATGLTSNPDGIHIDAISQRKFGL
                     RYFEAFHKKKHIMEALANESELIIPSNSKTYTKTEKIYINSMDLALGKISYDEFESKL
                     IKLNDN"
     gene            5392..5913
                     /locus_tag="KNP36_003551"
     CDS             5392..5913
                     /locus_tag="KNP36_003551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003442791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875378.1"
                     /translation="MIPLLILGLLKQNPNSYGYELLALMEKKHYKYIVNFTKGSFYYN
                     LQQLEEKKFIEKVENKQSNKNRETHNYIITELGCQEFEKLMYKYGSKTEYINLSFYAT
                     LLFANDYKNEKLIELLETQIKQTQVRISLLNESIENDKTNSHYFNRMLENSRSHHLVN
                     IEWFEKLLNDIRD"
BASE COUNT         2124 a          844 c          799 g         2248 t
ORIGIN      
        1 agaattttat tcctattgtg taaagtgaga atactatttt cttatattgg tataataata
       61 gtaaatctaa tatagaaaag aggtatttct agtatgcatg aaaataaaaa aaatctatta
      121 gacggaagct tagctcaata taatgataca gcagttccaa aaataccagt atttgctggt
      181 aacgatataa cttcagaagt ttattatttt aaacctaatc aagttcttaa tgctcataga
      241 caccctaatg gtgaacaaat atttgtgttc ctaaaaggag aaggtaaaat gaaacttggt
      301 gagcatgaat gtgatgtaaa aaacggcgat actgtatttg taccaacagg agagtggcat
      361 gaaattacta atggaagcaa tgaagaaatg gtagccgttc aaattacaaa aattaatgct
      421 ggagcagaat acagaggata gatatataag tacagttagt actttaatat ctattttatt
      481 atataaactt taatctcaaa tataaaaaga gtcttttaaa aggctctttt tatatttttg
      541 ttaattttca ttataaaaac aagaaaatat ctagctaaaa ctaatatatt ttatttaata
      601 ttttttatag cattgtttgc aaactcagta tttacgatat ctttataagg tgcttcctta
      661 tctagttctt tagcttcttt cataacagtc atcaatttct tcaaaccttc ctcttttaat
      721 acaggatttt gagaccatgc atctattgat ttatatctat ctacaactgt tgttaaatct
      781 tctaaagata tatcttcaaa gaaaggttgc atagccttag ctacttcttt gctagatgct
      841 tgttgaatcc ataattgacc tttataaaca gcatttgtaa atctttgaat taaatcttta
      901 ttgtttttca tgtatgatct cgtagtagag tatgctgtaa aaggtatttc tccagaatct
      961 tttcctatag atgtaactat atatccacta ccttcttttt ccattgctgt tgctgtaggt
     1021 tcaaatgctg ttgtaaagtc accctctcca cctgcaaaag ctccagccat tacaccaaat
     1081 tggtaatcag tctatttata acatttaaaa catataatta atctcttggg atattagggt
     1141 aaagtattaa agaaaaatca tcagattttt gattaggttc ttttttatag actgcgtaat
     1201 ttattacact tttaagcaat atatttttta gataaggttc tttttcctct gtatattcac
     1261 ttaaaatttt ttcaagttga ggaacaattt gtgttttaac tgtatttctt tccttttgca
     1321 tttcaatatc tatatttgtt ttattaatag cttctcttgc attttctata cgagataaga
     1381 gtatttttaa acgttcccca aatgtattac tgtcataaat tccttgttct aaaaaatcat
     1441 gtagtcgttc tttttgtttt tctaaagtat ccaattcttt atttaaattt atcaaggtat
     1501 gttctaaagt attttcaggt ttagagttgt ctttttcatc ttttaaagat agtctataat
     1561 ttactaacca tttatttaag acctctaata ttttattttc taatatgtat agtttagtag
     1621 ctttattttt acaattagta caaaccatat atttctcata tccatttgat gtagtattag
     1681 atttggctat taaagtatga ttacagtatc cacattttac aattccagcc aatggatttg
     1741 ttattttatt gtttggagta ggggaattaa tacgtttttt tcttatattt tgtgccttat
     1801 tccatatgtc ttcacttatt attggttcat gctttccttt tacctcaatt tgttcctcaa
     1861 ttcctcttgt tctactagaa tttcttttcc tctcgacttt attccatact atatatccac
     1921 aatacacttt gttttttata atatctctta tacccttttc ataccaagtt ctacctgttg
     1981 tggtcttata accaagttcg tttaaataat tggatatttt acatgcacca tctcctttta
     2041 aatacatatc aaagattatt ttaacaacag ttgctttatc ttcatttatt acaagtactc
     2101 tttctttatt atttaaatat ttaatatcat acccataagg aggagcttga gctataaatt
     2161 taccctcttc aatacttttg atttttcctc tttgcatacg tctagatatt aattttaatt
     2221 ccttacgagc cataaaagct tcaaattcag aatactcctc atcaaactca tcatttaaat
     2281 catacgtttt tctaggagta ataattttcg ttttagattt tttaaatgta tctagtatta
     2341 acccttggtc ttgcatatta ccacgaccca aacggtcaat atccatcact aaaacagcat
     2401 catagttatt atttttaatt tcacctagta attctagcat cttaggtcta tattctatac
     2461 tttccccaga aacaagttct tctttaattt caatgacatt taaattttgt tctcttgcta
     2521 gttttaaaag agttgtctta tgtctactta gagtttcaaa ttcacctcta tgttctgctt
     2581 cttcatcagc tctgcttttg cgtaaataaa ttgccacatt cattaaatca caccccttga
     2641 atatattata ttcagtaaca gattgattat atttaaaaca caaaaataaa ccttcaaaat
     2701 acaagatata ttttttaggt ttatttttat acagtaaatt ttatagtata tttaaaagct
     2761 tgtaatctaa gtaaatattt atactattaa ttttatgctt tcttcatttt ttaattttaa
     2821 actatttttt tactacaggt atccatactt caaatttagc attttgaggg tctggattta
     2881 agtacagttc aatatcagga ccattatcat attcataacc agaagtaggt aaccattctg
     2941 ttacaatacg cttttctagt tcttgtattg cttgtggaca ttgtccttct ccagaaaata
     3001 ttgcccaagt aaaagctgga acagtgtatt cttctaatgt attatctata gattttgtac
     3061 ttgaaacaga tataaaatac ttccattctt ctgaattatt acaaatactt atacctaata
     3121 caccttgaag ttgactatcc atcataggga ttaatttttg aagcgttcca tctaaagcaa
     3181 ccttttgcca catttgggga acaatttcaa aattcttttc tagttcatta tgaagtggct
     3241 gagatacacc aactatacga aatgcttctt tcttttcaat tctataattc atttcttcgg
     3301 ctcctttaat actaatttta aaactgattg gaggaaaggc ttttaaagtt gttatttctc
     3361 ttttttttat aactgatggg gcaacaccat gaatactttt aaatgcacga ttgaatgctg
     3421 ttggagaaga gtatccatat tttaaagcca catcaattat ctttttatca tcattttgta
     3481 attctacagc tgctaaagac atccgtctac gacgaatata ttcagaaagt ggtacatctg
     3541 ccatataagc aaacattctt tgaaaatgat atgtagaaca acaagctatt tttgccactt
     3601 gttcatactc aatttctttt gttatgtttt cttcaatata gttaattgct ttgtttaatc
     3661 tttcaatcca ttccataaaa tcagctcctt gtaatttata taatatctat tttaaaatag
     3721 ttaatcctct ctttctatgc actaattaac tagcttaata aagaatgaac atgagaaagt
     3781 ctgtaattaa ctacaaaaat gaacaaatag tattgttttt cacattaaag tatatcacaa
     3841 attagtatct aatttttata taagataaca gttttaattt attatgaaat ttttataata
     3901 ttttagctta gacatttaat tatatataac attttattta tagttaacta tttttgaagt
     3961 ttacccttaa tcaagcaaca cttagttatt caattataaa taatgattga gaataggaca
     4021 atttttaaga tacataaaat ataaagagga ggggatttaa atgccaaaca tagaaaaaga
     4081 cttagatggt acaactacta taacatacct caacgacgat ataggtgttc caacagacga
     4141 gaatggatat aaaatatcta tgacaatact acatggaaag acaatctgcc atgtagtatc
     4201 tcctgaaaca atcttaggaa gaaagttcac attagaagaa aaacaagaaa aagatacaat
     4261 aatatatgga gcaatagaaa aaataatggt agacagacaa ttacaaataa aaaattcaaa
     4321 caaagaagtt gctagtcatt agcacttctt taataagtaa agtaggacaa gtatttttta
     4381 taatattatt gacttatagt ctaattagac tataatataa acatagatag tctaattaga
     4441 ctactattaa aaataaatac aataagaatt taagaaagga taataataat aatgattaaa
     4501 tcatttttaa tgttaggaca gtccaatatg gctggaagag gattcataag tgaagtgact
     4561 ccaatttata atgaaagaat acagatgtta cgtaatggaa gatggcaaat gatgacagaa
     4621 cctattaatt atgacagacc agtttctggg gtaagtcttg ctgcatcatt tgcagatgca
     4681 tggtgctgtg aaaatcaaga ggatagaatt gggctaattc cttgtgctga gggaggcagt
     4741 tccttagatg aatggaatat agatggtata ctttttaaac atgctataag tgaagctaaa
     4801 tttgccatac aaagcagtga attgacagga attttatggc atcagggaga aaatgacagt
     4861 aataatggca actataaatt ttattataaa aaattacttt ctattattga aactcttaga
     4921 aaagaattaa atattccaga tataccaatt attattggtg gattgggaga cttcttagga
     4981 aaagtaggtt ttggaaaaag ttgtactgag tatgtattta tcaatcaaga gttacagaaa
     5041 tttgcttttg aacaagataa ttgttacttt gttacagcaa caggtcttac atctaatcct
     5101 gatggtattc atattgatgc aatatctcaa agaaaatttg gattacgtta ttttgaagct
     5161 tttcataaga aaaagcatat tatggaagca ttagctaatg aaagtgagtt gataataccg
     5221 agtaattcca agacatatac aaaaacagaa aaaatatata taaatagtat ggacttggca
     5281 ctaggaaaga tatcatatga tgagtttgaa tctaaactta ttaaacttaa tgataattag
     5341 ataaaatatt cattaatata ctaataaata tagattgaaa gaggtgattt tttgatacca
     5401 ttattaattt taggattatt aaaacaaaat ccaaattctt atggatatga gttattagca
     5461 ttaatggaaa agaagcatta caagtacata gtaaatttca ctaaaggttc tttttattat
     5521 aatttacagc aacttgaaga aaaaaagttt attgaaaaag ttgaaaataa acaatctaat
     5581 aaaaatagag aaactcataa ctacataatt actgaacttg gatgccagga atttgaaaaa
     5641 ttaatgtata agtatggttc taaaacagag tatataaatc tatcatttta cgcaacacta
     5701 ttatttgcaa atgattataa aaatgaaaag ttaatagaat tattggaaac gcaaattaag
     5761 caaactcaag taagaatttc tctattaaat gaatccatag aaaatgacaa aacaaattca
     5821 cattatttta atagaatgct agaaaattct cgttctcacc atttagttaa tattgaatgg
     5881 tttgagaagt tgctaaatga tattagagat tgattttaat aataaaaaaa catacatata
     5941 tattttatat aaatgtatga tatatagatt aaaaataagg cagataattt tcaattgaat
     6001 atctgtcttt ttgtt
//
LOCUS       DAEHWM010000152         5803 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.155, whole genome shotgun sequence.
ACCESSION   DAEHWM010000152 DAEHWM010000000
VERSION     DAEHWM010000152.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5803)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5803)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5803
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.155"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..980
                     /locus_tag="KNP36_003552"
     CDS             <1..980
                     /locus_tag="KNP36_003552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0875379.1"
                     /translation="IKNMNDLLEDNLLKLELIMISKSLLIVLIPLLKFIRLKTKINKR
                     DCIYLSIPLIANIIGVIVIFEFIFKDKIIDSKESLIILTISTVFLLSNLSLVSIIGRI
                     IKDNSLKIEYEITKKRMNMQYKYYLNLQEYQLKIRKLYHDMNNHIICIQNVYGKNEFA
                     DKYIKDINKQIKECNTIFNTQNMILDVILSDKKSICDMNNIYFLVDINFLECNFIEMP
                     DICSIFSNIIDNAIEACIKIKDTSIQKKIKLRGTVINRLFVIKCENTKINEVVLKNNK
                     VITSKKDSFLHGIGISSVKSSVEKYNGNVEIYSDKNKFTITIYIPLTRN"
     gene            1446..2744
                     /locus_tag="KNP36_003553"
     CDS             1446..2744
                     /locus_tag="KNP36_003553"
                     /inference="COORDINATES: protein
                     motif:HMM:NF015983.1,HMM:TIGR04085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0875380.1"
                     /translation="MIDSEEMIFNVEDLIIYRKNQLVIIYNKKFRKYIKLSEEIYKYF
                     LLGQENKIKIYDFVNYFDDESDKKYIINLIDIMNKNQIFKSNNLNFDMLSNGVAIYFC
                     LTNRCNLFCKHCCVESSSNKKDLLSTYDLKNIVDIISVLNTPHIIITGGEPLIREDFF
                     EIIKYIKQKLPDTKLILSTNGTLIDEHNVDFIITNFEKIDISIDGVDENTCSETRGKG
                     VFNKVISSVNLLKDNGFSNIKLSMVFGQKNSHLNKQFKDLNKKLGTEFVERYFIPTGR
                     GLENKESYLIEDTVLPITIPYILDNELKMCKDKKNKKMGCCACNAGNSQIFINYDGDV
                     YPCPSLIKDDYKMGNIFDNEFVKVIKENKTRDLKSLIKLESIYPYNFEKCKDCDVNIF
                     CWHCPAILDSVKDNELELDRWCSMMKHNLNTAVWGDEKVN"
     gene            2741..3757
                     /locus_tag="KNP36_003554"
     CDS             2741..3757
                     /locus_tag="KNP36_003554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0875381.1"
                     /translation="MKFTIFVTEDCNLRCTYCYEGNDKKKENMSYETADKTIDFICNK
                     ELESNSDYTTIVLHGGEPFINFDLIKYIHRDLVDRLSDKKILFDITTNGTIINDEIIE
                     FIAKNVKNISISIDGKKNIHDINRIDANGVGTYEKVMENGKRLIDKGIYVRARMTYNS
                     NTVKYLYESVYDIAKQGFKNIAPISDFMDKNWDNSHIKILNEQISKIMNIKKDYPDID
                     ISILDKQFINKKKGDCFGGINSYAIDTRGDVYPCTVCVGDKDILLGNIYDGLDDKKIK
                     NLIKIYISKNEECDGCTRLDYCMSTRCKLINKKVTGKFQSAVPIYCGLERVYVETTKK
                     LCSL"
     gene            3813..3974
                     /locus_tag="KNP36_003555"
     CDS             3813..3974
                     /locus_tag="KNP36_003555"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875382.1"
                     /translation="MIHIKKIEEKIELQDVEVQADPCKWYYDKHGIISQIDCMVDCAG
                     STPKGTVAY"
     gene            4182..>5803
                     /locus_tag="KNP36_003556"
     CDS             4182..>5803
                     /locus_tag="KNP36_003556"
                     /inference="COORDINATES: protein motif:HMM:NF014717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HBF0875383.1"
                     /translation="MINIKLAVSYLKRQKGKTLSLILSIGIAVMLVFSLSVINESQGQ
                     SDINHAYKNSGDYHAFYEDINSDIVKELNGEEDIKEFNDVLKFGEIISKDNGASLNLC
                     SYNKDFLDSTRYKLVKGREPRTSNELVIEQKVLDKMELDVKLNQTIDFQIVNEHINKN
                     NENSIYSKDKQFKIVGILSKSDEYYENLNKYKVRAFTYSNNGKDIVPYELITHMGTLK
                     LNTKDLDSQKVVNLGRKYKLTSNQFYPNTEVSMSMYMKNISKKTTYSIKQSLLPLLCA
                     TLVIYNMFNIIILDMTKQIGLLRAVGASKRNIRQVFFIQSIVVLSVGIVIGLLGGIVF
                     SYLGLMIVYDKSAELTINTNSIIESIIMSIIAVILASVVPIYKAGNLSIIDAIKKTDK
                     LNYIPRLLLLKSHKKVVGIINEIAFKNIFRNKVTSIIIIITISLCGVLFIGRLTSTKF
                     IYGKESDSANITSKSYGNFDIYLGYSPINANYTFSKYDNSLLNEIKAIEDVTDVEPNI
                     YLKGYLRNADLEEDYLDELKRTEINNNNESTV"
BASE COUNT         2475 a          476 c          897 g         1955 t
ORIGIN      
        1 ctataaaaaa tatgaatgat ttattagagg ataatttgtt gaagttagag ttaataatga
       61 tatctaaatc attactaata gtattaatac cattgcttaa gtttatcaga ttaaaaacaa
      121 aaataaacaa gagggattgt atatatttat ctattccatt aatagcaaac attattggtg
      181 taatagtaat atttgaattt atttttaaag ataagattat cgattctaaa gagagtttaa
      241 taatacttac aatatcaact gtatttttac tatcaaatct ttcattagta agcataatag
      301 gaagaataat aaaagataat agtttaaaga tagaatatga aattacaaaa aaaagaatga
      361 atatgcaata taaatattat ttaaatttac aggaatatca gttgaaaata agaaaactat
      421 atcatgatat gaataatcat atcatttgta ttcagaatgt ttatgggaaa aatgagtttg
      481 cagataagta tattaaagat ataaataagc aaataaaaga atgtaatact atatttaata
      541 ctcagaatat gattctagat gttattttaa gtgataaaaa atctatttgt gatatgaata
      601 atatatattt tctagtagat attaattttt tagaatgtaa ttttatagag atgccagata
      661 tatgtagtat attttcaaat ataatagata atgcaataga agcttgtatt aagattaagg
      721 acacaagtat acaaaaaaag attaaattaa gaggaactgt tataaatagg ttatttgtaa
      781 taaaatgtga aaatacaaag ataaatgaag ttgtattaaa aaataataag gttattacaa
      841 gtaagaaaga ttccttttta catggaatag gaataagtag tgtaaaaagt tcagtagaaa
      901 aatataatgg aaatgtggaa atatactcag ataaaaacaa gtttacaatt actatttata
      961 taccattaac taggaactaa ttctagttgg ggctctaaat tgcccagttg gagcagtagt
     1021 attgaaagat aaaatagaag atgctatctt taaggcatag gatatttgga ggtgataaaa
     1081 atggttgaat gctatgctaa taagataaca tcctttttag tactcaataa aataatagaa
     1141 caaaaaatgt gatttatatt tgtttgaatt taaaatgttg ataggtttta tagttatatt
     1201 atttgcatga tatatcttaa ataaatttag aaaaatagag ttatttttat ctgcaaatgc
     1261 gaccttagta tggtaacatt attgaccaaa agttctatat agtataaaaa aataaaatgt
     1321 aaatttgata aactttataa ctaggaacat aaaaacaaca attaaataac taattagata
     1381 gtaaagttga tattagtaat aaatattaaa gaaaaatatt ttactaattt gaggaggact
     1441 tagttgtgat agattctgaa gaaatgattt ttaatgtaga agatttaatt atttatagaa
     1501 aaaatcaact agtaattatt tataataaga aatttagaaa atatattaaa ttgtctgaag
     1561 aaatatataa gtattttctt ttaggacaag aaaataaaat aaaaatttat gattttgtaa
     1621 attattttga tgatgaaagt gacaaaaaat atattattaa tcttatagat attatgaaca
     1681 aaaatcaaat ttttaaaagt aacaatttaa actttgatat gttaagcaat ggtgttgcaa
     1741 tttatttttg tttgacaaat agatgcaatt tattttgtaa acattgttgt gttgaatctt
     1801 cttctaataa gaaagattta cttagtacat atgatttaaa aaatatcgta gatataatat
     1861 cagttttaaa tactcctcat ataattataa ctggtggaga accattgata agagaagatt
     1921 tttttgaaat aattaaatat ataaaacaaa aattacctga taccaaatta atattatcca
     1981 caaatggaac tttaatagat gaacataatg ttgattttat tataactaat tttgaaaaaa
     2041 tagatattag tattgatgga gtagatgaaa atacttgtag tgaaacacga ggaaaaggtg
     2101 tatttaataa agtaataagc tctgttaatc tgctaaaaga caatggattc agtaatataa
     2161 agctgtctat ggtatttgga caaaaaaatt ctcatttaaa taaacaattt aaagatttaa
     2221 ataaaaagct tggaacagaa tttgttgaaa gatattttat tccaacagga agaggcctag
     2281 aaaataaaga aagctattta attgaagata cagttcttcc aattacaatt ccgtatattt
     2341 tagataatga attaaaaatg tgtaaagata aaaaaaataa aaaaatggga tgttgtgcat
     2401 gtaatgcagg aaactctcaa atatttataa attatgatgg agatgtatat ccttgtcctt
     2461 cactgataaa ggatgactat aaaatgggaa atatatttga caatgaattt gtaaaagtta
     2521 taaaagaaaa taaaacaaga gatctaaagt ctttgattaa attagaaagt atttatccat
     2581 ataactttga aaaatgtaaa gattgtgatg taaatatttt ttgttggcat tgcccagcga
     2641 tattagattc agttaaggat aatgaattgg aattggatag atggtgtagt atgatgaaac
     2701 acaatttaaa tacagctgta tggggagatg aaaaagttaa ttgaaattta ctatatttgt
     2761 aactgaagac tgcaatttga gatgtacata ttgttatgaa ggtaatgata aaaaaaaaga
     2821 aaatatgagt tatgaaactg ctgataaaac aatagatttt atttgtaata aagaattaga
     2881 aagtaatagt gattatacaa caattgtttt acatggagga gaaccattta taaattttga
     2941 tttgattaaa tatatacata gggatttagt agatagattg agtgacaaaa agatattatt
     3001 tgatataact acaaatggaa ctattataaa tgatgaaata atagagttta tagcaaagaa
     3061 tgtaaaaaac atatcgataa gtattgatgg aaaaaagaat atacatgata taaatagaat
     3121 agatgctaac ggagtaggta cttatgaaaa agtaatggaa aatggaaaaa gacttataga
     3181 taaaggtata tatgttaggg caagaatgac atataactca aatactgtta agtatcttta
     3241 tgagagtgta tatgatatag caaaacaagg gtttaaaaat atcgcaccaa tttcagattt
     3301 tatggataaa aattgggata attctcatat taaaatatta aatgaacaaa ttagtaaaat
     3361 tatgaatatt aaaaaggatt atcctgatat agatatatct attttagata aacaatttat
     3421 aaataagaaa aaaggagatt gttttggagg gataaatagt tatgcaatag atactagagg
     3481 agatgtatat ccatgtacag tatgtgtagg agataaagat attttactag gaaatatata
     3541 tgatggatta gatgataaaa aaattaagaa ccttataaaa atttatatat ctaagaatga
     3601 agagtgtgat ggatgtacta gacttgatta ttgtatgtca accagatgta aacttatcaa
     3661 taaaaaggta acaggtaaat tccaaagtgc agtaccaatt tattgtggat tagaaagagt
     3721 ttatgtggaa acaacaaaaa aactatgtag tttataatct agtttaacta gttataataa
     3781 atataaaaca aaagtaaagg gggatatgta ttatgataca tataaaaaaa atcgaagaaa
     3841 aaatagaact tcaagatgtt gaggtgcaag cagatccatg taaatggtat tatgataagc
     3901 atggaataat ttcacaaata gactgtatgg tggattgtgc aggatcaact ccaaaaggaa
     3961 cagtagctta ttaaaaaata ctaatcagtc tattaaatat gttgaaagta ctagatgtag
     4021 ttttttacaa atgaaatgtg attttctcaa ctctagtatt tttaataatt aaatttaact
     4081 agcacaacga gttagttagt atttaatgaa tagtgctcta taacctacta ttttaggtta
     4141 tagagttttt cttgtaaata tgaataagga ggattctgat tatgataaat attaaacttg
     4201 cggtgtcata tttaaagaga caaaaaggaa aaactttatc attaatactt agtataggga
     4261 ttgctgttat gctagttttt tcattaagtg ttattaatga atctcaagga caatcagata
     4321 taaatcatgc atacaaaaac tcgggagatt atcatgcttt ttatgaagat ataaatagtg
     4381 atatagtaaa agaacttaat ggtgaagaag atataaaaga attcaatgat gtacttaaat
     4441 ttggagaaat tataagtaaa gataatggag catctctaaa tttatgctct tacaataaag
     4501 attttttaga ttctactaga tataagttag ttaaaggtag agagcctaga acttctaatg
     4561 aattagtaat agaacaaaaa gttttagaca aaatggaatt agatgtcaaa ttaaatcaaa
     4621 ctattgattt tcagattgtt aatgagcata taaataaaaa taatgaaaat tctatttata
     4681 gtaaagataa gcaatttaaa atagttggta ttttaagtaa atctgatgaa tactatgaaa
     4741 atttaaataa atataaggta agagctttta catattcaaa caatggcaaa gatattgttc
     4801 catatgaatt aataactcat atgggtacat taaaattgaa tacaaaagat ttagattctc
     4861 aaaaagtagt gaatctaggg agaaaatata agttaacaag taatcaattt tatccaaata
     4921 cagaagtaag tatgtctatg tatatgaaaa atatttcaaa aaaaacaact tattcaataa
     4981 agcaaagctt actcccttta ttatgtgcaa cattagtaat atacaatatg tttaacataa
     5041 taatactaga tatgaccaag caaattggtt tacttagagc tgttggagct agcaagagaa
     5101 atattagaca ggtatttttt attcagagta ttgtagtttt atctgtaggt atagtaattg
     5161 gtttacttgg aggtatagtt ttttcttact taggtctcat gatagtatat gataaaagtg
     5221 cagaattaac tataaataca aactctataa ttgaatctat catcatgtca attatagcag
     5281 ttatattagc ctctgtagta ccaatatata aagctggaaa tttatctata attgatgcta
     5341 taaaaaagac agataagtta aattatattc ctaggctttt gttgttaaaa tcacataaaa
     5401 aagttgttgg aattataaat gagatagctt ttaaaaatat atttaggaat aaggttacat
     5461 caataataat aataattacg atatcactat gtggggtttt atttataggc agactaactt
     5521 ctacaaaatt catatatgga aaagagtcag attcagctaa tataacaagt aaatcatatg
     5581 gcaattttga tatttatttg ggatattcac caataaatgc aaattataca ttttctaaat
     5641 atgataattc tttattaaat gaaataaaag ctattgaaga tgtaacagat gttgaaccca
     5701 atatttattt aaaaggatat ctaagaaatg ctgacttaga agaagattat ttagatgagc
     5761 taaaaagaac tgaaataaat aataataatg agtctacagt ttt
//
LOCUS       DAEHWM010000153         5686 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.156, whole genome shotgun sequence.
ACCESSION   DAEHWM010000153 DAEHWM010000000
VERSION     DAEHWM010000153.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5686)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5686)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5686
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.156"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            427..804
                     /locus_tag="KNP36_003557"
     CDS             427..804
                     /locus_tag="KNP36_003557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875384.1"
                     /translation="MMIRKIPQAELKVMKFIWKVDVTVTSKDVIEAMEQKYGWKQTTT
                     LTLLSRLVKRGFLDAQKIDRYTHYTIRVKHKDYLSFETKDFLSNIHDDSLRSLISALH
                     DDENIGKDKLDFLESYFDNLKDE"
     gene            797..1945
                     /locus_tag="KNP36_003558"
     CDS             797..1945
                     /locus_tag="KNP36_003558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protease"
                     /protein_id="HBF0875385.1"
                     /translation="MNNYMLYVFENLIKTTIVCSLGICLLLFLKRYLFKKFSKRFNYY
                     IWLIIVFRMLLFLFNYTIVYEVKEPKENALGNNITQIDISTDNNLMLYVAYLWLFVTI
                     VIAVYTFIKYTRFKNLVVDVSYDIEDNDINCIYKNLLKELNIKKKIELRGSDELISPA
                     GMGLFKSYIFLPDYPYSKDELTWILKHELMHFKNKDILIKFLVLSVRIIYWFNPLVYV
                     MSNKVNLDCELCCDESVLVECSLKDKKEYALALIKSIKFSKNYNSKILTTEFDKTNLE
                     KRLESIVKKKGKSGILIAVLVFMTSITSFVEVDAQVRIDEGNNGMNNNINEFLLNKTT
                     DKIINIYYKDAPNEIRKFYEDKCELEGKIPRDYDIIEMDMKDYNQLIK"
     gene            1962..2564
                     /locus_tag="KNP36_003559"
     CDS             1962..2564
                     /locus_tag="KNP36_003559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-binding protein"
                     /protein_id="HBF0875386.1"
                     /translation="MLTKLRKIVAIMCCLLLTFTSVAFADTSKEKGGSKETVPEKNLD
                     SFTLSGYIYTYENAPQEIRDEHKQNCEEINIDPKPDDEIFVPESANLMNEDNSKGVYA
                     SYTVSYNIGAKTITIMSNEYLTISTTKVIRKGNSGKEVKAAQIMLTLLGYNVGIDSSF
                     GSKTYNAVVSFQKKYGLSADGIIGPATWDKLGRLTDPTLS"
     gene            complement(2657..3679)
                     /locus_tag="KNP36_003560"
     CDS             complement(2657..3679)
                     /locus_tag="KNP36_003560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBF0875387.1"
                     /translation="MDYNDLLKSARENFNGTCKVCKICNGLACAGDVPGMGGKGSGSS
                     FIENRKSLEKIKINMRVIHNVSKPDTSIELFGRKMSSPIFAAPVSGTILNMGGKVSEK
                     EYIEPVVRGCSNSGIYAMVGDTNVDTFLLDNLDVLKDNRGNGIVFIKPWNNSKIIDKI
                     RLSEEAGAFAVGVDLDACGLINNQFQENPFSPKTIDEIRELVESTRLPFIIKGIMTVD
                     DALMAVESGASAIIVSNHGGRVLDYTPGTCEVLPDIAKSVKGKITILVDGGVRTGVDV
                     VKMLGLGADAVLMGRPFVTASFGGGLDGVEFFIEKVRNELCETMILTGCQNVKDIDGR
                     VIWNLL"
     gene            complement(4008..4190)
                     /locus_tag="KNP36_003561"
     CDS             complement(4008..4190)
                     /locus_tag="KNP36_003561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875388.1"
                     /translation="MYKDKSDECIHLMTAYIDSISGYYSFIDTQLEDFMMKYGENIVD
                     SNLHSIMMLLCKWGLS"
     gene            4503..4922
                     /locus_tag="KNP36_003562"
     CDS             4503..4922
                     /locus_tag="KNP36_003562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3785 domain-containing protein"
                     /protein_id="HBF0875389.1"
                     /translation="MSLYKFIYDDKEYLLKEENCSALINDEENPVQGVSISKIIDILN
                     EAEEVDFDVEYYQEACPLCLEGVKEKKKFFPFLEYHFYIFSKDGEYVISNISVDYKGL
                     SFNKLSRANKVDNSYIVSVIICENCQDYIVQIENCIV"
     gene            5053..>5686
                     /locus_tag="KNP36_003563"
     CDS             5053..>5686
                     /locus_tag="KNP36_003563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0875390.1"
                     /translation="MEEIDDTILDSMFKLTLNERLLTNNDFIENKIDVVKNLIDCYKT
                     EQNSLMLLKSNFLLALLYGIQGFSEKMKEYILISCKYIDKCLPKDYKFLARFYSQIAI
                     LSLKNEDVNKANLYMDKFNLICDENNFLIEEIIFKSQLIYIKASKCIESSVIIKEIET
                     LYIKIKEINDFNCKKIYFFIIGKIYFLFLDDALIAKVNFLKARKYADLLKD"
BASE COUNT         2259 a          649 c          800 g         1978 t
ORIGIN      
        1 ttatgaaagg tataattata aaagtcttat tcaataaaat ttataattaa tttagatata
       61 tttgtaaata atcagtataa aatagatgtt ttaatagcat aaaggcataa ttagaatgtt
      121 attaaaattt attagatatt actctagttt attttaaaaa aaagtattat aatattcctt
      181 gtgtgaaaat ataggaattt ttattaaata gttttaatgt gtaaataaca ttctacacta
      241 ttgtaattaa atatgtaaaa agtaaaatat ttaaatagat atattttaaa atctaacttt
      301 taatattgta aaaaaattag aaatttaaca aaaagtacaa aaattcacat ttttttcata
      361 aagtgtttga ctaaaaaatt cacatgttgt agaattaagg tagcaggagt tttgagggag
      421 gtgtaaataa tgataagaaa aataccacaa gcagaactaa aagtaatgaa attcatttgg
      481 aaagtagatg ttacagtgac atcaaaagat gttattgaag ctatggaaca aaaatatggc
      541 tggaaacaaa ccaccacact gacactttta tctaggctgg taaaaagagg attcttagat
      601 gctcaaaaaa tagacagata tacacattac acaataagag taaaacacaa agattattta
      661 agttttgaga caaaggattt cctaagtaat atacatgatg actctttaag aagcttaatt
      721 tcagcattac atgatgatga aaatataggt aaagataagc tagattttct agaaagttat
      781 tttgataatt taaaggatga ataattatat gctatatgtt tttgaaaatc ttataaagac
      841 aactattgta tgtagtcttg gtatttgtct attattattt ttgaaaagat atttatttaa
      901 gaagtttagt aagagattca attattatat ttggttgata atagtcttta gaatgttact
      961 ttttctattt aattatacaa tagtgtatga agtaaaagaa cccaaagaaa atgcattagg
     1021 aaataatatt acacaaattg atatttctac agataataat cttatgctgt atgtagctta
     1081 tttatggtta tttgtaacta tagtcattgc agtttataca tttataaagt atacaagatt
     1141 taaaaatcta gttgttgatg tatcttatga tattgaagat aatgatataa actgtatcta
     1201 caaaaacttg ttaaaagaat taaatataaa aaagaaaatt gaattaagag gttctgatga
     1261 attgataagt ccagcaggta tgggattatt taaatcttac atattcttac cagactatcc
     1321 ttatagtaaa gatgaactaa cttggatttt gaaacatgaa ttaatgcatt ttaaaaataa
     1381 agatatttta ataaagtttt tagttttgtc tgttagaata atatattggt ttaatccact
     1441 tgtatatgta atgagcaata aagtaaatct agattgtgaa ttatgttgtg atgaaagtgt
     1501 tttggtagaa tgttctttaa aagataaaaa agaatatgca ctagcactta taaagtcaat
     1561 taagtttagt aaaaattata atagtaagat tttgacaacc gagtttgata agacaaattt
     1621 ggaaaagaga cttgagagta ttgttaaaaa gaaaggcaaa agtggaatac taattgctgt
     1681 tttagtattt atgacttcta taacatcttt tgttgaagtt gatgctcaag ttagaattga
     1741 tgagggtaat aatggaatga ataacaatat taatgaattt ttattgaata agacgactga
     1801 taaaattata aatatttatt ataaagatgc accaaatgaa attaggaaat tttatgaaga
     1861 taaatgcgaa ttagaaggta aaatacctag agactatgac ataatagaaa tggatatgaa
     1921 agattataat caattaataa aataattata aggaggattt tatgttaaca aaattaagaa
     1981 aaatagtagc tattatgtgt tgcttattgc ttacttttac aagtgtggca tttgctgaca
     2041 caagtaaaga gaaaggagga agtaaagaga ctgttccaga gaaaaaccta gattctttta
     2101 ctctttctgg gtatatatat acatatgaaa atgcgccaca agaaataaga gatgaacata
     2161 aacaaaattg tgaagagata aatatagacc ctaagccaga tgatgagata tttgttccag
     2221 aatcagctaa tctaatgaat gaggacaata gtaaaggtgt ttatgcaagt tatactgttt
     2281 cttataatat aggtgctaaa actataacaa ttatgagtaa tgagtatttg actataagta
     2341 caacaaaagt tatacgaaag ggtaatagcg gaaaagaagt aaaagctgca caaatcatgt
     2401 taactttact tggttataat gtaggtatag atagttcttt tggaagtaag acatataatg
     2461 cagttgtaag tttccaaaaa aaatacggtt tgtctgcaga tggaataatt ggtccagcta
     2521 cttgggataa attgggtaga ctaactgacc ctactctttc ataggattaa aatctaaaaa
     2581 tatattaaat agtgtctcaa tatgattttt caatttaaat gagacactat ttaaatataa
     2641 atgttataaa actattttac aataaattcc atataactct accatctata tccttaacat
     2701 tttgacaacc agtcaaaatc atagtctcac ataactcatt cctaaccttc tctataaaaa
     2761 actccacacc atcaagacca ccgccaaaag aagcagtaac aaaaggtctt cccatcaaaa
     2821 cagcatcagc acccaatcca agcatcttaa ctacatcaac accagtccta actccaccat
     2881 caacaagtat tgttatcttt ccctttacag acttagctat atctggaagt acctcacaag
     2941 taccaggagt ataatcaagt actcttccac catgatttga aacaataatg gcactagcac
     3001 cagactctac agccatcaaa gcatcatcta cagtcataat tccttttata ataaaaggta
     3061 atctagtgga ttcaaccaat tctctaatct catcaattgt tttaggagaa aaaggatttt
     3121 cttgaaattg attattaata agtccacaag catcaaggtc tacaccaact gcaaaagcac
     3181 ctgcttcttc agacaatcta attttatcta ttatctttga attattccaa ggctttataa
     3241 atacaattcc atttccccta ttatccttca atacatctaa attatccagt aaaaaagtat
     3301 ctacattagt atcgccaacc atagcataaa ttccagaatt agaacaacct ctaacaacag
     3361 gctctatgta ttctttttcg gaaactttac cacccatgtt caatatagta cctgatacag
     3421 gtgcagcgaa tataggagaa ctcatttttc taccaaataa ttctatggat gtatctggct
     3481 ttgaaacatt atgtatgact ctcatattta tctttatttt ttctagactt tttctatttt
     3541 caatgaaaga cgaaccactt cctttaccac ccataccagg aacatctcca gcacaagcta
     3601 atccattaca aattttacat actttacatg ttccattaaa gttctctcta gctgatttta
     3661 gtaagtcatt gtaatccata caaaatctct cctttttata atattaaaat tgagtattac
     3721 tatattgaaa atatcttaat tgtaaatata gggatgttat tatgatgagc taaactagat
     3781 aatacatatt agatattttt tattgttgta gatagttaaa ttatatcata ttagatagtc
     3841 aaattttgaa aaaaactaac ttatttaagt atacattttg aaaaaattaa aaaagctata
     3901 tatagatttt taaagaaatc tatatatagc ttttaagttt atgtcaatct tttttgttaa
     3961 tgaataaata atatagaata caatatacaa aaaagtttct tgaaatgcta agataatccc
     4021 catttacaaa gcaacatcat tatactgtgt aaatttgaat caacaatgtt ttcaccatat
     4081 ttcatcataa aatcctctaa ttgtgtgtca ataaatgaat aatatccact tatactatcg
     4141 atgtatgcag tcattaagtg tatacattca tcacttttat ctttatacat atatatctcc
     4201 ccctatatac aatatataaa tttagatacc aaatcgtatc atattaaata gttaagtgtg
     4261 taacatctat gcagttatat atttatatca ttatattaat aactaaagtg agttttgaca
     4321 atagattttg ggaaactgga tgttcaaagt gcaaacttgg attttaaaat cattaattaa
     4381 gatagcgcat aggaatatat gtatacataa cttaattata aagattataa acaattactt
     4441 ttattaactt tatttaaatg gtagaataac ttggagatta ataattataa ggaggatata
     4501 atatgagttt atataagttt atatatgatg ataaggaata tttattaaaa gaggagaact
     4561 gtagtgcttt aataaatgat gaagaaaatc cagttcaagg agtaagtatt tcaaaaataa
     4621 ttgatatact taatgaagca gaagaagttg attttgatgt agaatattat caagaagcat
     4681 gtccattatg tttagaagga gtaaaagaaa agaaaaaatt ctttcctttt ttagaatatc
     4741 acttttatat tttcagtaaa gatggagaat atgtaataag caatatatct gttgattata
     4801 aaggactatc ttttaataaa ctatcaaggg caaataaagt tgataatagt tatattgtaa
     4861 gtgtgataat ttgcgaaaat tgtcaggatt atatagttca gatagaaaat tgtatagttt
     4921 agtgtaaagt atgtcttaat ttaagagaaa tttctaaatt gagacatcaa cttttttcaa
     4981 aaatagtatg gaaaattact aaatttatga gataatgtaa gtcggaggtg agttacaata
     5041 tatagtaaat atttggaaga gatagatgat acaattttag attcaatgtt taaactaacc
     5101 ttgaatgaaa gattattgac taataacgat tttattgaaa ataaaattga tgtagtaaag
     5161 aatttaattg attgctataa aactgaacaa aatagtttaa tgttattaaa atcaaatttt
     5221 ttgctagctt tattatatgg tattcaaggg tttagtgaaa aaatgaaaga gtatattttg
     5281 atttcctgta aatatattga taaatgctta cccaaagatt ataaattttt agcacgattt
     5341 tattcacaaa tagctatttt aagtttaaaa aatgaagatg taaataaggc aaatttatat
     5401 atggataaat ttaatcttat ttgtgatgaa aataattttc taattgaaga aattattttt
     5461 aaatcacaac ttatttacat taaggcaagt aagtgtatag aatcttctgt aataattaaa
     5521 gaaatagaaa cgttgtatat aaagataaaa gaaattaacg attttaattg taaaaaaata
     5581 tattttttta ttattggtaa aatatatttt ttgtttttgg atgatgctct aattgctaag
     5641 gtaaattttt taaaagcaag aaaatatgca gatttactaa aggata
//
LOCUS       DAEHWM010000154         5607 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.157, whole genome shotgun sequence.
ACCESSION   DAEHWM010000154 DAEHWM010000000
VERSION     DAEHWM010000154.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5607)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5607)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5607
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.157"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(753..2159)
                     /locus_tag="KNP36_003564"
     CDS             complement(753..2159)
                     /locus_tag="KNP36_003564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0875391.1"
                     /translation="MDSVKYILRRFIGSSILISLLFIVLNIAGFLLFSYMLFVSKYSD
                     NLDTSDSREIKSNLIMIEDNLILRDGKFILDDSSKEVLHKNKVWAMLIDNNGDRIWGF
                     DLPKEIPSHYTLTDVAKFSRFFLKDYPVYVWEHPNGILVTGYPKDKYTKFNLTYTVKE
                     IEQFPMLIIGMFLVNAIVTFLIALFIGLKMVKSIKPIITGIKLMSKGEPVLLQEKGIL
                     SDISKSINTVSKELQMKDEKLRKKEEARSNWIAGISHDIRTPLSMIIGYAGELEESSS
                     LSNREQEQVSIICNQGIKIRELVNDLNLVSKLEYNMQTLNCDKIRVSAFLRELISEFI
                     NNNLDNDFYVELDILNEDIIIDADKKLLKRAISNLIQNSITHNQQGCNIRVTSKSDLD
                     FCYIIVEDDGKGMSQERINSLLKSQNGLSEAYAKGQNHGLGILIVSGIINAHRGKLDI
                     TSIDSQGLKTILKLPLIK"
     gene            complement(2204..2911)
                     /locus_tag="KNP36_003565"
     CDS             complement(2204..2911)
                     /locus_tag="KNP36_003565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875392.1"
                     /translation="MESIKDKKILVVDDHKELLKMIDEILRKEGFSRVFLASSYEEAV
                     RVFRNVKPDCAILDVVLPDGDGFSIMRKIRETSKIPVIFLSARGEDEDRLIGLGLGAD
                     DYIVKPFLPKELTLRLVGILNRVYVPIEEEELPVFKLGDSVVVNLNSACVEKDGQEIS
                     LTAKEHSLLLKLYENKGRIVTNDSLCQAIWGDDMYGYENTLMVHVRRVREKIEKTPST
                     PKHLITVRGLGYKLMIN"
     gene            3082..3996
                     /locus_tag="KNP36_003566"
     CDS             3082..3996
                     /locus_tag="KNP36_003566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875393.1"
                     /translation="MEMIIRTQRLSKEYNKIFRVKDIDLRVPQGAVYGFLGPNGAGKS
                     TTLKMLLGLAKPTQGNINILGKELNEKNRISILKDIGSLIESPSYYGHLTGLENMTIM
                     QRLLDLPKKNVNEALKIVRLENQKNKKVSQYSLGMKQRLGIAMAIMKFPKLLILDEPT
                     NGLDPAGIEEIRELIKSLPEKYGMTVLISSHLLSEIDQIATSIGIINHGELVFQDSIK
                     ELHNRGQSQIAIKTKNVVSAQKLLNTKGYMSLIQDGYLTIENLKDSDVAKINGMLVHS
                     NIDVFRIEEHKKSLEDIFLELTGKAVTL"
     gene            3996..4757
                     /locus_tag="KNP36_003567"
     CDS             3996..4757
                     /locus_tag="KNP36_003567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875394.1"
                     /translation="MKYLGLEFYKLKRKKIILMTFLFAAVEIMWCIVNSNRAITRNPD
                     MLGGFEYSYMLMSFASLNGLFFPILISIITSRISDIEHKGDTWKLLKSSVTSLNSIYL
                     SKFLCSAILVSIPVLMQVLSIVLFGHFRGVIESISVSLLLKYTLGTILVSIAIIALHL
                     WIATVIPNQMIAITFGMIGSFIGLTSGLFYQGIRRLFIWSYYLELSPLSYAYDNVLGS
                     SVYRIDMNFSITILVFLIGMLIYYIGRNHLLKKEV"
     gene            4769..5506
                     /locus_tag="KNP36_003568"
     CDS             4769..5506
                     /locus_tag="KNP36_003568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875395.1"
                     /translation="MLRKSVLGEILKLKNSFIWYVLLALPLISVLIGSGNFYLNQGIL
                     KKEWYSLWTQVSLFYGEFFFPILIAIFCAYICRLEHMNHNWNNVMTLPVNLKNIFLSK
                     LTVVSILTAITQVFFVIFYIVAGNMFGFSGSVPKELTGWIAKGWIISISIASIQLYMS
                     IKIRSFATPIGISLCLSLFGMGLIVAKPAVGIFFPYSMLGSAMGVIKQSALNVNDTIV
                     TICVAFITTIVFSEIANRNFRKNDVIS"
BASE COUNT         1942 a          856 c          706 g         2103 t
ORIGIN      
        1 actaaacttc ctactttcta aatttcttgc ttcttaagaa taatgttaat tttaatttta
       61 agattatagt ttttaccttg tttaattgaa acattctata taattatatc cttctatttt
      121 agagtttttt tatttatata ttacaaagtt taaatttttt cattaattat attataaatt
      181 ttccatatat ttcaacataa atacatatat atatatgtta tttctaaaaa tactacacaa
      241 aaactctact ttagtagaac tcaatggcgc aaaatacttc aatttaaaac atttatcgta
      301 ctttaaataa ataactataa taaaatatac ttacaatagt tacatagaag ctattataac
      361 tacacagaac agcttataat taaaactttt ttaggatgtc attatatttt ttcttaaaat
      421 taaaaaacac tataccataa ttctatttta gtagaatttt tttgtcaata ataaaattaa
      481 atattaacta aaaaataaaa aaaatggaat tatctaaaga atttaataac cttacaataa
      541 ttccaaaata ttatttctat gaaaattttg ataccatgag taactcagcc ataagcgcat
      601 aaagcacaag ttactcttta ctttaataaa acttgacaag aaaagaattt atccttattc
      661 tactctaata gagttaattt gtcaataaag aataaaatta ttttcaaaat attttcattc
      721 ttcattctta tctgttatta ttttataaaa tatcacttaa ttagaggtaa ttttagtatt
      781 gtttttagtc cctgactatc aatgctcgta atatctaatt tacctctatg tgcattaata
      841 atgccagata ctatcaaaat acctagacca tgattttgac ctttggcata tgcctcactt
      901 agtccatttt ggctctttaa taaactatta attctttctt gactcatacc ttttccatca
      961 tcttcaacaa ttatatagca aaaatctaaa tcagacttag aggtaaccct tatattacat
     1021 ccttgttggt tatgagttat actattttgt attaaattac taatagccct ttttaataat
     1081 tttttatctg catctataat aatatcttca tttagtatat caagttcaac gtaaaagtca
     1141 ttatccaaat tattatttat aaactcagaa ataagctctc tcaaaaacgc agaaactcta
     1201 atcttatcac aattcaatgt ttgcatatta tattcaagtt tagacactaa atttaggtca
     1261 tttactaatt ctctgatttt aatcccttga ttgcatataa tagacacttg ctcttgttct
     1321 ctatttgaaa ggctactgct ttcttcaagt tctccagcat atccaattat cattgaaagt
     1381 ggagttctta tatcatgaga tattcctgca atccagttag acctagcttc ctctttcttc
     1441 ctaagttttt catctttcat ttgcaactct ttagatacag tattaataga ttttgaaata
     1501 tcacttagta ttcctttttc ttgtaaaagt actggttctc cttttgacat aagctttatg
     1561 ccagtaataa ttggttttat agatttcacc atttttaaac ctatgaatag agctattaaa
     1621 aaagtaacta ttgcattaac cagaaacata cctattatta acataggaaa ttgttctatt
     1681 tccttaaccg tataagtaag gttaaactta gtatacttgt cttttggata acctgttact
     1741 aatattccat ttggatgttc ccatacatac acaggatagt cctttaaaaa gaaccttgaa
     1801 aactttgcta catctgtcaa agtataatga cttggaattt cttttggtaa atcaaatccc
     1861 catattctat ctccattgtt atcaattaac attgcccaaa ctttattttt atgtagtact
     1921 tccttactag aatcatctaa aataaacttt ccatctctta aaatcaaatt atcttcaatc
     1981 ataatcaagt ttgattttat ttctctacta tcacttgtat ctaaattatc agagtattta
     2041 gatacaaata acatatatga aaacagaaga aaacctgcta tatttaatac aataaaaagt
     2101 aatgaaatca agatacttga acctataaat cgcctcaata tgtactttac actatccaaa
     2161 attaaatcac tcctcttgat ttcttttatt ctaatatcta aaattaatta atcatcaact
     2221 tatatccaag acctcttact gtaataagat gtttaggtgt agatggagtt ttttctatct
     2281 tctctctaac ccttctaaca tgaaccataa gggtattttc atatccatac atatcatctc
     2341 cccaaatggc ttgacatagt gaatcattag taacaattct ccctttattt tcatacaact
     2401 ttaaaagcaa cgaatgctct ttagctgtta aagaaatctc ttgcccatct ttctcaacac
     2461 atgcactatt taaattcaca acaacagaat ctcccagttt aaatactggc aactcctctt
     2521 cttctatagg cacatataca cgatttaata tacccacaag ccttaaagta agttcctttg
     2581 gtaaaaatgg ctttactata taatcgtcag cccctaagcc caaaccaatc aatctatctt
     2641 catcttcacc tcttgcagag agaaaaatca ctggtatttt agatgtctct ctaatttttc
     2701 tcataataga aaaaccatct ccatctggca atacaacatc taaaattgca caatctggct
     2761 ttacatttct aaatacccta acagcttcct cataacttga tgctaaaaat actctactaa
     2821 atccctcttt tctcaggatt tcatctatca tttttaataa ttccttgtgg tcatcaacca
     2881 caagtatttt tttatctttt attgactcca taatcatcac cctcctttag tataccatat
     2941 acccattttc acaactttgc ctaaatagac ttttaaggtt attgtaaggt aaatttcagc
     3001 taattgaaat gtaaccaagt tattatactg atataagtta aaagaatcaa taagcacaga
     3061 ttaaaaaagg ggatgaaaca tatggaaatg ataattagaa cacaaagact ttcaaaggaa
     3121 tacaataaaa tatttagagt aaaggatata gacctaagag ttccacaagg agctgtatat
     3181 ggttttttgg gtcctaatgg agctggaaaa tctaccactc ttaaaatgct tcttggactt
     3241 gctaaaccca cacaaggaaa tattaatatt ttaggtaaag agttaaatga aaaaaataga
     3301 atatcaattt taaaagatat aggttctttg atagaatctc catcatacta tggtcatctt
     3361 acagggcttg aaaacatgac cataatgcaa agactcttag atttacctaa aaaaaatgta
     3421 aatgaagcat taaaaattgt aaggttagaa aatcaaaaaa ataaaaaagt tagtcaatat
     3481 tctttaggta tgaagcaacg tcttggcatt gctatggcaa taatgaagtt tcccaaatta
     3541 ttaatacttg atgaacctac aaatggactc gacccagcag ggattgagga aattagagaa
     3601 ttaataaaat ctctaccaga aaaatacggg atgactgttc taatctctag ccatctttta
     3661 agtgaaattg accaaattgc cacatcaata ggaataataa atcatggcga actggttttt
     3721 caagatagca taaaagaact tcataataga ggtcaaagtc agattgctat caaaactaag
     3781 aatgttgtat ctgcacaaaa actattaaat actaaaggat atatgtcact tatacaagat
     3841 gggtacttga ctattgaaaa tttaaaagac tcagatgtcg ctaaaataaa tggtatgctt
     3901 gtccattcaa atatagatgt atttagaata gaagaacata aaaaaagctt ggaagatata
     3961 ttcttagaac ttactggtaa ggcggtgact ttataatgaa ataccttggt ctagaatttt
     4021 ataaacttaa aagaaagaag attattctga tgaccttttt atttgcagct gttgaaataa
     4081 tgtggtgtat cgtaaattca aatagagcta ttacacgtaa tccagatatg ttaggtggat
     4141 ttgaatattc ctatatgctt atgagttttg caagtttaaa tggtctattc tttcctatct
     4201 taatatcaat aattacatca cgtataagcg atatagaaca taaaggagat acatggaagc
     4261 ttttaaaatc ttctgtgaca tctttaaata gtatttattt atctaaattt ttatgttctg
     4321 ctattttggt atctatacct gtattgatgc aagtgttatc tattgtgttg tttggacatt
     4381 ttagaggggt tattgagtca atttctgtat ctttactttt aaaatacaca ttaggaacaa
     4441 ttcttgtaag tattgctatc attgcactac acctatggat tgcaactgta attccaaatc
     4501 aaatgattgc aattacattt ggcatgattg gtagttttat aggtttgaca tcaggtttgt
     4561 tttatcaagg tattcgtaga ttgtttatat ggtcttatta cctagagtta tcacctttaa
     4621 gttatgctta tgataatgtt ttaggttcat ctgtctatag aattgatatg aatttttcta
     4681 ttacgatttt agttttctta attggaatgc taatttatta tattggaaga aatcatttat
     4741 taaaaaaaga agtataggag ggatttaaat gttaaggaag tcagttttgg gagaaattct
     4801 aaagttaaaa aattctttta tatggtatgt attattagct ttgccactta taagtgtgtt
     4861 gattggttct ggtaattttt atctaaatca aggcatactc aaaaaagaat ggtacagctt
     4921 atggactcaa gttagtcttt tttatgggga atttttcttt cctatcttaa tcgcaatctt
     4981 ttgtgcatat atttgtaggc ttgaacatat gaatcataat tggaataatg taatgacact
     5041 gccagttaat ttaaaaaata tctttttatc taaacttaca gtagtttcaa tacttacagc
     5101 tattacacaa gttttctttg ttatctttta tatagttgca ggaaatatgt ttggtttttc
     5161 tggtagtgta cctaaagaat tgactggttg gattgctaaa ggttggatta tttctatttc
     5221 aatagcttct atacaattat acatgtctat aaagattaga agttttgcaa ctcctattgg
     5281 tattagtctt tgcctttctc tatttggtat gggattaata gtagcaaaac ctgctgttgg
     5341 tatatttttc ccttattcta tgttaggtag tgctatgggg gttataaagc aatctgcttt
     5401 aaatgttaat gacactatag ttacaatatg tgttgcattt attactacta tagtattttc
     5461 tgaaattgcc aatagaaatt ttagaaagaa tgatgttatt tcttaatggt aaatgctaga
     5521 tatttttggg tttgaaattt atattctttt tagttgaaat ctatatccat tttatttaaa
     5581 aatatatatc ttttatttga attttat
//
LOCUS       DAEHWM010000155         5549 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.158, whole genome shotgun sequence.
ACCESSION   DAEHWM010000155 DAEHWM010000000
VERSION     DAEHWM010000155.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5549)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5549)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5549
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.158"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(399..950)
                     /locus_tag="KNP36_003569"
     CDS             complement(399..950)
                     /locus_tag="KNP36_003569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875396.1"
                     /translation="MSINTVIAKNLNRLRNERNLSLGQLAELSGVSKVMLSQIEKGDS
                     NPTVNTIWKIASGLNVPYTAILEQPQNETFIVSKTDIDVQVSENKDYRLYCYYPNTPT
                     RNFELFQMELEEGHSYTSVGHSEKSQEYIMIIEGQLKLEVNDSIYQLRENDSICFSAE
                     SIHTYHNQGEKTLKAVIINYYPV"
     gene            1141..2103
                     /locus_tag="KNP36_003570"
                     /pseudo
     CDS             1141..2103
                     /locus_tag="KNP36_003570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896810.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase family protein"
     gene            2398..4242
                     /locus_tag="KNP36_003571"
     CDS             2398..4242
                     /locus_tag="KNP36_003571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HBF0875397.1"
                     /translation="MQKRILRNFIFTGKNILSKLVFIIKYNFSTLILFELFHKGLALF
                     FIWPSIRYIFDILIKSLHIVYLNMDNFIKVLTNPMSIVLIILSVIILAFYAFFEFTSV
                     IICFNKSIKYEKIGLFELFKISFKNSIKLLYPKNILLFIFVILIIPLVNTVLISGFIG
                     KIQIPEYILDYIKSDIILNIIYMIFLLIIYISVIRWIFSIHEITLNTENFKRARKESV
                     NLIKGKIIRTIIYSLILSLVVAIIGYAIYHSGIIFIGIWTKYCTDMEFLKNVFINRCI
                     AFEEYFRLILSIFIFILDIGFISATYYQYKGVNISKNNIKKEKKSISKIVFNLVLILL
                     ISYIESVAFSSHINGMFNTSFSFYTTAIAHRAGAEMAPENTLAAIEEASHAKADYAEI
                     DVQETKDGELIVLHDSNFKRTTGVDKNVWDVNYNEVKTYDAGSFYYYGKGYYDEKFVG
                     EKIPTLKEMIKYSKGKVKLLIEIKLNGHEKGDVVKKVVQLIKENNFENQCIVASMDKT
                     ILQKVKKLDENLLTCYFMAIAYGDFSKLNYVDIYGIESTFVNKTVVEKIHKMNKKIFV
                     WTVNSDSLIEKMLDLNVDSIITDNPYLIESAIYWKKNGFISQVSDYLF"
     gene            4564..5148
                     /locus_tag="KNP36_003572"
     CDS             4564..5148
                     /locus_tag="KNP36_003572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar O-acetyltransferase"
                     /protein_id="HBF0875398.1"
                     /translation="MTEREKMLAGELYDCGDIELLTQWHKAKGLVRDYNQTDSSDLEK
                     KEKILNELLGGKGKNLWITAPYYVDYGNNIYFGNNCEVNMNCTFLDDNKIIIGDNALI
                     APNVQIYTAFHPTNAGDRFGNAKEDGSFEFCKTQTAPVTIGDNVWIGGGAIIMPGVTI
                     GDNVVIGAGSIVTKDIPSNMIAYGNPCRIIRENK"
BASE COUNT         2147 a          553 c          872 g         1977 t
ORIGIN      
        1 aaataaacta aaagggataa taaaatagct tttaggttat ggtaataaag gtatttaaaa
       61 agagtgcata agcactccaa ttgtgagaaa tacatacaca aatcattatt acaacaatga
      121 aaaatgtaca tataagagac gttttgtatt tgttttaagt gataatattt taatactaac
      181 taaataatta tcacaatagt aaaaaagaaa aaggagtatt ttgtactcca tttgtcaaaa
      241 atataaaact tttatataag cttattataa cataattgat aaaagtgtaa agatatataa
      301 tgaatttata aagaaaaata aaataaaaaa gataaatcct aatcaaagga tttatctttt
      361 tgtatagaaa ataattattc tattattaaa tggcatggct aaactggata ataatttatt
      421 attactgctt tcaatgtttt ttctccttga ttatggtatg tatgaattga ttcagctgaa
      481 aaacaaatag agtcattttc tctaagttga taaatagagt catttacttc taattttaat
      541 tgaccttcta taatcataat atattcctgt gatttttcag aatgaccaac agatgtataa
      601 ctatgacctt cttctaattc catttgaaat aattcgaagt ttctagttgg tgtattggga
      661 taataacaat aaagacgata atctttattt tctgaaactt gtacatctat atcagttttt
      721 gatacaataa aagtttcatt ttgaggttgt tccagtattg cagtatatgg aacatttagt
      781 ccacttgcaa ttttccaaat tgtgtttact gttgggtttg agtctccctt ttcaatttgc
      841 gaaagcatta ctttacttac gccagataat tcagcaagtt gacctagact taagttacgt
      901 tcattacgta atctatttaa atttttagca ataacagtat taatactcat agtagctcct
      961 taaaatgtaa attattgaca aatataattt acgaatgtat aatttattta acattattta
     1021 taatttacaa atgtataata taatgaacgt taaatacact gtacatccgt aatataaatt
     1081 atactgcata aagagttgtt tttcaacgga tgatagttga gagattaagg gggaattgta
     1141 atgcgtgtac ttaataatgt tacagaggct ataggcaata ctcatatgtt acatttatcc
     1201 aaaatagcag atgaatttgg agttcaaggt aatatttatg caaagatgga atacttaaat
     1261 ccgggattta gtaaaaagga ccgtgtagca ttacaaatga ttaccgaagc agaaaatgca
     1321 ggtttattag ttccaggtca agcagttgtg gaattaacaa gtggtaatac tggaacagga
     1381 ctagcaatag cttgtgcatg taaaggatat aaatttatag cgtgtatgtc aaaaggaaat
     1441 tctatggaaa gagcaagaat gatgaaagct ttaggtgctg aagtagttct tgtagaccaa
     1501 atgcctaatt cagttcatgg acaggtatct ggtgaagatt tggcacttgt agaaattgag
     1561 gctcaaaaaa tagcaaaaga aagaaatgca tttagagcag accaatttaa tttagaagct
     1621 tgtaatcatg cacatgaaaa gtatacagca gaagaaatgt gggaataatt ggatggaaat
     1681 attgatgtat ttgtagattt tcttggaagt ggtagtactt ttgcaggatg ttcaaaaaca
     1741 cttaaaaaac ataattcttc tatcaaatgt tatgttgttg aacctgaaac agcagcaatt
     1801 tattcaggta aagaaataac tgaccaaggg cataaaatac aaggtggagg atattctatg
     1861 gatttgccat tagtagacaa gaaacttatt gatggttata ttcaagttac agacgaggag
     1921 gcaactgatg tagcaagaaa attagctaaa ttagaaggtg tatttgcagg attttcttca
     1981 ggggcaaatg tatgtgcagc aattaagttg ttaaagagca gtgaaaaagg aaaaaatata
     2041 gttttaactc ttaatgatag tggtttaaaa tatttaagta ctgatttata tgaagaattg
     2101 taataatagc acaatagtta tgcaatgttt tttaaattaa gtatatagat ttaaattata
     2161 aaaagtatct caatgtaatt tttgaaagtt ataaaggaga tactttttta ttttgtaaat
     2221 atggagtatc ctacttataa gtattaagct atatagatat tgatgattag ctatgcaata
     2281 aaaaagagta tgtgtttttg catttataca tcataacttg gaataataca tattaatgtt
     2341 ctaaatgtat ttaaaacata tgataaaatt agaacaaata gatacaagga gataaaaatg
     2401 caaaagagaa ttttaagaaa ttttatattt acgggtaaaa atattttaag taaacttgtt
     2461 tttataataa aatataattt tagtacatta attttatttg aattatttca taaaggatta
     2521 gccttatttt ttatatggcc atctattaga tatatatttg atattttaat aaaaagttta
     2581 catatagtct acctaaatat ggataatttt ataaaagttt tgaccaatcc catgtcaata
     2641 gttctgataa tactatcagt tataatacta gctttttatg cattttttga atttacctct
     2701 gtaattattt gttttaataa atcgataaaa tatgaaaaaa tagggttatt tgaactcttt
     2761 aaaatatcat ttaagaactc tataaaattg ttatatccta aaaatatact attatttata
     2821 tttgtgatat taataattcc attagtaaat acagttttaa tttcagggtt tataggaaaa
     2881 atacaaatac cagagtacat actagattat ataaagtctg atataatttt aaatataatc
     2941 tatatgattt ttcttttaat aatatatatt tcggttatta gatggatttt tagcattcat
     3001 gagataactt taaatacaga aaattttaaa agagcaagaa aagaaagtgt taatcttata
     3061 aagggaaaga ttataagaac aattatttat tcattaatat tatctttagt agtagctatt
     3121 attggatatg cgatttatca tagtggaatt atatttatag gcatatggac taaatattgt
     3181 actgatatgg aatttttgaa gaatgtattt ataaatagat gtattgcatt tgaagaatat
     3241 tttagattga ttttatcaat attcattttt atattggaca ttggatttat ctcagcaact
     3301 tattatcaat ataaaggagt aaatatttct aaaaataata ttaaaaaaga gaaaaaatct
     3361 atatcaaaaa ttgtttttaa tttagtatta atattattga tttcttatat agagtcagtt
     3421 gcattttctt cacatataaa tggtatgttt aatacgtcat tttcatttta tacaacagca
     3481 attgctcata gagcaggagc tgaaatggct ccagagaata ctttggcagc aatagaagaa
     3541 gcttcacatg ctaaagctga ttatgcagaa atagatgttc aagaaactaa agatggagaa
     3601 cttattgtac ttcatgattc aaactttaag agaactacag gagtagataa aaatgtttgg
     3661 gatgtaaatt ataatgaagt aaagacatat gatgcgggaa gcttttatta ttatggaaaa
     3721 ggttattatg atgaaaagtt tgttggggaa aagataccaa cactcaaaga aatgataaaa
     3781 tattctaaag gtaaggtgaa attattaata gaaataaaac ttaatggaca tgaaaaggga
     3841 gacgtagtaa aaaaagttgt tcagttaatt aaagaaaata attttgaaaa tcaatgtata
     3901 gttgcatcta tggataaaac tatattacaa aaagtaaaaa aactggatga gaatttattg
     3961 acatgctatt ttatggcaat tgcatatggt gatttttcaa agttaaatta tgttgatata
     4021 tatggaattg aatcaacttt tgttaataaa acagtagtag aaaagattca taaaatgaac
     4081 aaaaaaatct tcgtttggac tgttaatagt gacagtttaa ttgagaaaat gcttgaccta
     4141 aatgtagata gtattattac agataatcca taccttatag agagtgcaat ttattggaag
     4201 aaaaatggat ttattagtca agtgtcagat tatttatttt aaatattcta taattgtatt
     4261 atccagtaaa agagatatta ttaaaatcaa taatatctct ttttaacata aataaggttg
     4321 ttaaattaag gttattctta taaaaattgt gcttatcagc tataaacaag gaataaaagt
     4381 gaaaaaattg ctctgagatt attacagtta aaagagtttt aagatgacag agagatagat
     4441 tgtcaactgt atatttaata aatcttgtta tttattaaat tttatataag taaaatatat
     4501 aaattaataa atcttatgct agaatatata tgaaaaacaa tataaatttg gaggattaaa
     4561 aacatgacag agcgagaaaa aatgttggca ggagaacttt acgattgtgg tgatattgag
     4621 ttgttaactc aatggcataa agcaaaaggc ctagtaagag attataacca aacagattcc
     4681 tcggatttgg aaaaaaaaga aaaaatatta aatgagttac ttggtggtaa gggtaaaaac
     4741 ttatggatta ctgcaccgta ttatgtagat tatggaaata atatttattt tggaaataat
     4801 tgtgaagtca atatgaattg tacgttttta gatgataata aaattatcat tggggataat
     4861 gcactaatcg caccaaacgt acaaatatat actgcatttc atccaactaa tgctggtgat
     4921 agatttggta atgccaaaga agatggttca tttgaatttt gtaaaactca aacagctcca
     4981 gttactattg gagataatgt ttggattggc gggggtgcta ttatcatgcc aggtgttact
     5041 attggagata atgtagttat aggtgcagga agtattgtta caaaagatat tccaagtaat
     5101 atgattgcat acggaaatcc atgccgtatt attcgagaaa ataaataaag ttaaattttc
     5161 ttgcaaaatc tcaaaaaaca cctttcttac tttatacata gggtattttc taatactttc
     5221 acatccatat tcatttgtta aatttttgtg gaatgtagtt tttatcactt ctatcttaca
     5281 tttccaccat ttttttataa aagtcattcc tttatagatt tatttataat agtatatatt
     5341 ctatttgatg tttgaataag cacttatttt taagtaaaat actaactttt aggttagtat
     5401 tttgctatag tatgatgatt aagtaagaat aaaatactat aatacataaa gcttaataaa
     5461 tataattttt attttactta gatattttct tttgattagc aatcaaaagt agttataatt
     5521 tttttaatta ataagagtaa catttattt
//
LOCUS       DAEHWM010000156         5489 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.159, whole genome shotgun sequence.
ACCESSION   DAEHWM010000156 DAEHWM010000000
VERSION     DAEHWM010000156.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5489)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5489)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5489
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.159"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            100..1281
                     /locus_tag="KNP36_003573"
     CDS             100..1281
                     /locus_tag="KNP36_003573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBF0875399.1"
                     /translation="MNKKYIKAGNLIDGTGNSIMQNKGIIIDGDTIVEIEDIRDDLNG
                     YDVYDYLDKTVMPGIMNCHVHLTMEPVGNPKIYYDNVSDVELVVNTIKQLDAYLDSGV
                     TYIRSLGCPKYVDVQLKNLIDKGSIDGPGIVTSGPVICMTGGHGYYFGIESDGVDECR
                     KSARTVLKNGVDCVKIMATGGVTTDGVEPGSPQLTLEEMKAAVDEAIKAGKITATHAQ
                     GRTGIKNAVLAGITSIEHGVYLDDEIIDLMLERGTYLVPTVAAPYFILNAGKESGITE
                     ATLRKCEIVAIPHKESFLKAYKKGIKIAVGSDAGTSYNEHGKTYYEMKLMSDYGMDNM
                     DIIVAATKTASELLRIDKNYGTLEKGKKADVIVVNGNPVENIDVLADVLAVFKLGKKV
                     R"
     gene            complement(1423..2340)
                     /locus_tag="KNP36_003574"
     CDS             complement(1423..2340)
                     /locus_tag="KNP36_003574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875400.1"
                     /translation="MENNKCREDFRFTQEYEEDYPNTNERYYENYQVADRYYNYPNKY
                     KEPKIKQCCCKKSMREALELLRYDALRPFVNFNQFAFISDFFIVGANLVGIDLSAPPK
                     DNLSGLDGTFERFSACNCDLIDIAGRVSYPIPVPLTLEGLINTIGTIPGVAELIALID
                     AVIPPTIDLGAILDAILAAIIDFILAASTPLANVDLASLCNLKAVAFDITPADYEDFI
                     ASLGYYLDKKHYKECNCNCDCDDCCCNKGILDNLYMSNINNQVTVVAGSLVLTGVEVL
                     GKKNDVIVLGNSNDSRIYFVCVDSIDYIA"
     gene            2593..3387
                     /locus_tag="KNP36_003575"
     CDS             2593..3387
                     /locus_tag="KNP36_003575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875401.1"
                     /translation="MIEVDKLCKSFTRVVKDDKNKSSIRKLKKVKTKKEEFFAVNNVS
                     FKVMEGEIVGILGPNGAGKTTLLRMLGGILTPTSGSINISGYDYSIDRNSAKKEIGYL
                     SGNTKLYGRLSPRELLTTFASLYEMSKEDIEESIENIVKIMDMSEFIDNRIENLSTGQ
                     TQRTSIARCLIHSPKVYIFDEPTLGLDVLSSASIIDFMKNEKLRGKTVLYSTHYMEEA
                     ETLCDKIFMIHNGKIIASGTPQSLKEESGVNNLRDVFIKLARKEDI"
     gene            3388..5448
                     /locus_tag="KNP36_003576"
     CDS             3388..5448
                     /locus_tag="KNP36_003576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBF0875402.1"
                     /translation="MRSKIVKYIFKKEMLDILRDKKTLFMMIVVPLLLYPLLMLLMIQ
                     VMNMSASSMNSKDINIAFNNKPNKVLVSMIEDDNLEKDTKNTSNDKGKIRVLDVDNYK
                     KSLEENKIDAYIKMEEKKSSINYQIYINSSQENSSNALKRIETVLDKYKRFTIEKTLS
                     EKGLDVQATLEPITYSTVDVAKTEEVAGYFLGQILPFILIIGVLLGSIYPAIDVMAGE
                     KERGTLETLFTLPISNLELVMGKYMAVSLSAIVTAILNILSMGLTMAFILVSGGISSQ
                     FGFGNFNYGDLVLPIITTLICICLFSMVVSAISMCVCSLAKSFKDAQNYITPLMLIIM
                     IPSYVSMIPNIVLDRVTAVIPVVNISLLIKSVLSFKSDLNLIALVLASNVAFVILAII
                     LLSKMFNSEEILFGNSKSFSFLEKRSNIKKGSIPTVSDGVILYAVGLVLLIYVGSLVQ
                     IKFGMAGIIMTQFMIISLPLLFAYYIKADFKEVFSLTVPKLKHVFGSIVLWIGGYILI
                     MIITQLILFLFPQNMEVAESLNKALFIKDSVLLNLLAIALLPAICEEMFFRGFIFSSF
                     SKSKDKNKSIKLAIICSGVLFGIMHMDFIRIIPTSILGIIFAYSVYKSGSIFVSMLLH
                     FLNNSVAVVLNHYTTGNITNLYKFVEVDFSNLNVLKFALILLISLILIMLGLRVLDRK
                     SLRN"
BASE COUNT         2100 a          625 c          909 g         1855 t
ORIGIN      
        1 aatttgaaat agaatgctta tagtggtaaa attaattatt agaatattag aaataataaa
       61 taaataatac attgtactta aaagggggag aaatttaaga tgaacaaaaa atatattaaa
      121 gcagggaatt taattgatgg aaccggaaat agtattatgc aaaataaggg tataattatt
      181 gatggagata ctatagttga aattgaagat ataagagatg atttaaatgg atatgatgtg
      241 tacgattact tagataaaac tgttatgcca ggcattatga attgtcatgt tcacttgaca
      301 atggagccag ttggaaatcc aaagatatat tatgataatg tatcagatgt agagcttgta
      361 gtaaatacga taaaacaact tgatgcttat ttggattcag gagtaacata tattagaagc
      421 ttaggttgtc ccaaatatgt ggatgtacaa cttaaaaatc ttatagacaa agggtctata
      481 gatggtcctg gtatagttac ttcaggtcca gttatatgta tgacaggagg gcatggatat
      541 tattttggta ttgaaagtga tggagtagat gaatgtagaa aatcagccag aacagtttta
      601 aaaaatggag tagattgtgt aaagataatg gcaactggag gtgtaacaac tgatggagtt
      661 gagccagggt caccacaatt aactttggag gaaatgaagg ctgctgtaga tgaagctata
      721 aaagcaggta aaataactgc cacacatgca caaggaagaa ctggtataaa aaatgcagtg
      781 cttgcaggaa ttacttctat agaacatggt gtttatttag atgatgaaat aattgatttg
      841 atgcttgaaa gaggaactta cttagttcca actgtggctg caccatattt tattctaaat
      901 gcaggaaaag aaagtggaat aactgaagct actcttagaa agtgtgagat tgttgccatt
      961 ccacacaaag agtcattcct aaaagcatat aaaaaaggaa ttaaaattgc agttggttct
     1021 gatgcaggaa cttcttataa tgaacatgga aaaacatatt atgaaatgaa actaatgtca
     1081 gattatggta tggataatat ggatataata gttgctgcta caaaaacagc atctgaactt
     1141 ttaagaattg ataaaaatta tggaactcta gaaaaaggaa agaaagcaga tgttatagtt
     1201 gtaaatggaa atccagtaga gaatatagac gtacttgcag atgtgttagc agtatttaaa
     1261 cttggtaaaa aagttagata aatagtataa aaataaaaaa gagtgtctaa agaaattttt
     1321 aaataattat agacactctt ttttattagt aataattaaa tcttttatac tttagaaaat
     1381 agattctatt ttatatttag atataactct ttaaaatcat tcttatgcaa tataatctat
     1441 agaatctaca catacaaagt atattcttga atcattagaa tttccaagta ctataacatc
     1501 atttttctta cctagaactt caacaccagt tagaaccaaa ctaccagcta ctacagtaac
     1561 ttgattattt atatttgaca tataaagatt atctaggata cctttattac aacagcaatc
     1621 atcacaatcg cagttgcaat tacattcttt gtaatgtttt ttatcaagat agtaacctaa
     1681 agatgctatg aaatcttcat aatctgcagg tgtaatatca aatgcaacag ctttaagatt
     1741 acacaatgat gctaaatcta cgtttgctaa tggagtagat gcagcaagta taaaatcaat
     1801 tatagcagca agtattgcat ctaatatagc cccaaggtct atcgtaggag gaataactgc
     1861 atcaataagt gcaattaatt cagctactcc tggtatagtt cctatagtat taattaatcc
     1921 ctcaagagtt aaagggactg gaataggata agatactcta ccagctatat ctattaaatc
     1981 acagttacaa gcagaaaatc tttcaaaagt accatcaagt ccagataaat tatcttttgg
     2041 aggagctgaa agatctatac ctaccaaatt agcacctact ataaagaaat ctgagataaa
     2101 agcaaattga ttaaagttta caaaaggtct tagagcatca tatcttagaa gttctaatgc
     2161 ttctctcata ctttttttac aacaacattg ttttatttta ggttctttat atttatttgg
     2221 ataattatag tatctatcag ctacttgata attttcatag tatctttcat ttgtatttgg
     2281 ataatcttcc tcatattctt gtgtaaatct aaagtcctct ctacatttat tattttccac
     2341 taaatacact ccttttatat tttaatttaa atgtatagat aattaagctt atctatatag
     2401 taatattata tttataatgt aaaaaaatgt tacaaaagat attataaacg aataaaaaat
     2461 aataatttgt cagataaact tgtaaatttt tatgaataat ccattctaaa acaaaaaact
     2521 gtgtataaaa aaggtttata tgttatattt atataaatat aacatatgaa cgagaaagga
     2581 gtggtttgat aaatgattga ggtagataaa ttgtgtaagt cttttacaag ggttgtaaaa
     2641 gatgataaga ataaaagttc aataagaaag ctaaagaaag taaaaactaa aaaagaagaa
     2701 ttttttgctg taaataatgt ttcatttaaa gttatggaag gtgaaattgt tggaatatta
     2761 ggtccaaatg gtgcaggaaa gactacatta cttagaatgt taggtggcat attaacacca
     2821 acatcaggaa gtataaatat ttctggatat gattattcaa tagatagaaa ttcagcaaaa
     2881 aaagaaatag gttatctctc tggaaataca aaactatatg gaaggctttc tccgagagaa
     2941 cttctaacaa cttttgcaag tctatatgag atgtcaaaag aagatataga agaatcaatt
     3001 gaaaatattg taaaaataat ggatatgagt gaatttatag ataatagaat tgaaaatcta
     3061 tcaactggtc agactcaaag aacatctata gctcgttgtt taatacattc tccaaaagta
     3121 tatatttttg atgagccaac actaggtctg gatgttttaa gtagtgcatc tattatagat
     3181 tttatgaaga atgaaaaact aaggggaaaa actgttcttt actcaactca ttatatggaa
     3241 gaagcagaaa ctttatgtga caagattttt atgattcaca atgggaaaat aattgcatca
     3301 ggaacaccac agagtttaaa agaggaatct ggagtaaata atttgagaga tgtattcata
     3361 aaacttgcca gaaaggagga catttaaatg agaagtaaga ttgtaaaata catatttaaa
     3421 aaagaaatgt tagacatatt gagagataaa aagactttat ttatgatgat tgttgtgcca
     3481 cttcttttat atcctttact tatgttatta atgattcaag taatgaatat gtctgcaagt
     3541 agtatgaata gtaaggacat taatatagct tttaataata aacctaataa ggtgttagta
     3601 tccatgattg aagatgataa tttagaaaaa gatactaaaa atacttcaaa tgataaaggc
     3661 aaaataagag tgttagatgt agataactat aaaaagtcat tagaagaaaa taaaattgat
     3721 gcttatataa agatggaaga aaaaaaatca tctataaatt atcaaatata tataaattct
     3781 tctcaagaaa attcttctaa tgcactaaaa agaattgaaa ctgttttgga taaatataaa
     3841 agatttacca tagaaaaaac tttatctgaa aaaggattag atgtacaagc tactttagaa
     3901 ccaataacat atagcactgt agatgttgca aagacggaag aagtggcagg atacttttta
     3961 ggtcagatac ttccatttat attaataata ggagttttac taggttcaat atatccagca
     4021 atagatgtta tggctggaga aaaggaaaga ggtacattag aaacattatt tacactgcca
     4081 atatcaaact tagaactggt tatgggaaaa tatatggcag tttctcttag tgcaatagta
     4141 acagcaattt taaacatttt atctatggga ctgactatgg catttatttt agttagtgga
     4201 ggtattagta gccaatttgg ctttggaaac tttaattatg gagacttagt cttaccaatt
     4261 ataactactt taatttgcat atgtcttttt tcaatggtag tttcagcaat aagtatgtgt
     4321 gtatgttcat tagcaaaaag ttttaaagat gctcaaaact acataacacc tcttatgtta
     4381 attattatga taccatcata tgtttctatg ataccaaata tagtattaga tagagtgaca
     4441 gctgtaatac ctgtagtaaa tatatcttta cttataaaaa gtgtattatc ttttaaaagc
     4501 gatttaaatt taatagcctt agttttagca tcaaatgtag cctttgttat attggcaatc
     4561 atactactgt ctaagatgtt caattctgag gaaatacttt ttggtaatag taagagtttt
     4621 tctttcttag agaaaagaag taatataaaa aaagggtcta taccaactgt aagtgatggt
     4681 gttattttat atgcagtagg attagttcta ttgatttatg ttggttcttt agttcaaatt
     4741 aaatttggta tggcaggtat tataatgaca caattcatga taatttcttt accattatta
     4801 tttgcatact atattaaagc tgattttaaa gaggtattta gcttgacagt tcctaaatta
     4861 aagcatgtgt ttgggagcat tgttctttgg attggtggat acatacttat tatgattata
     4921 acacagctaa ttttattctt atttcctcaa aatatggaag ttgctgaaag tttaaataag
     4981 gctcttttta tcaaagatag tgttttactg aatttactag caatagcttt attaccagct
     5041 atatgtgaag aaatgttttt taggggattt atattttctt catttagtaa atcaaaagat
     5101 aaaaataagt ctatcaaact cgctataata tgtagtgggg tactatttgg tattatgcat
     5161 atggatttta ttagaataat tccaacatca atattaggta ttatatttgc atacagtgtg
     5221 tataaatctg gttcaatatt tgtatcaatg ttattgcatt ttttaaataa tagtgtagca
     5281 gttgtgttaa atcattatac aactggaaat ataaccaact tatataaatt tgttgaagtt
     5341 gatttttcga acttaaatgt gcttaaattt gccttaattc ttctaataag tcttatatta
     5401 attatgttag gattaagagt tttagataga aagtctttaa gaaattaagt ataaagttat
     5461 tatatagatt aaaatattaa taagcacta
//
LOCUS       DAEHWM010000157         5464 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.160, whole genome shotgun sequence.
ACCESSION   DAEHWM010000157 DAEHWM010000000
VERSION     DAEHWM010000157.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5464)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5464)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5464
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.160"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            51..2282
                     /gene="pflB"
                     /locus_tag="KNP36_003577"
     CDS             51..2282
                     /gene="pflB"
                     /locus_tag="KNP36_003577"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HBF0875403.1"
                     /translation="MNAWQGFKTGRWTKEINVREFIQLNYSPYEGNDSFLAGATENTK
                     KLWDEAMVLFKKERENGGTLDVDTKTVSGIAAYAPGYLDKELETIVGLQTDAPLKRAV
                     MPYGGIKMVENSCEAFGYELDPEIKDIFTKYRKTHNQGVFDVYTPEMRAARKSGIITG
                     LPDAYGRGRIIGDYRRVALYGVDALIEDKNEQKKSLEVSCMDEEVIRLREEITEQISA
                     LNELKKMAESYGFDISKPATNSKEAVQWLYFGYLGAVKDQNGAAMSLGRTSTFLDIYF
                     ERDLKAGIVTEEELQEYMDHFVMKLRMVKFLRTPDYNNLFSGDPTWVTECIGGMGIDG
                     RTLVTKNSFRMLNTLYTLGPSPEPNLTVLWSTKLPQGFKDFCSKVSIDTSSVQYENDD
                     LMRAYWGDDYGIACCVSAMRIGKQMQFFGARVNLAKTLLYAINGGVDEKSGVQVGPRF
                     EPITSEYLDYDEVMSKFEPFTDWLATLYVNTLNVIHYMHDKYSYEALEMALHDRDIFR
                     TMACGMAGLSVCADSLSAIKHAKVKTIRNEQGIAVDFEIEGDYPKYGNNDDRVDSIAV
                     ELVESFMNKIRKNKTYRNSYPTQSILTITSNVVYGKKTGNTPDGRRAGAPFAPGANPM
                     HGRDTNGALASLSSVAKLPYEHAQDGISNTFSIVPGALGKDMTERINNLSAMMDGYFA
                     QNAHHLNVNVFDRATLEDAMEHPEEYPQLTIRVSGYAVNFIKLTKEQQLDVINRTFHG
                     KMA"
     gene            2442..3176
                     /gene="pflA"
                     /locus_tag="KNP36_003578"
     CDS             2442..3176
                     /gene="pflA"
                     /locus_tag="KNP36_003578"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HBF0875404.1"
                     /translation="MIKGKIHSIETFGTVDGPGIRYILFFQGCPLRCKYCHNRDTWDI
                     KSGKEYTVDEIITDALKYTSFMKFSGGGITASGGESTLQPEFLSELFKKAKENDIHTC
                     LDTSGFVDIETIDPVLDNIDLVLLDLKHMVEEKSIDLTGVGMDKALKLARHLESRNIP
                     VWIRHVLVPGITDDIDNLEKLGQFVATLKNVERFELLPYHSMGIHKWESLGIDYELKD
                     VPDATKEDVQKASEIISKFGVKVYNS"
     gene            complement(3298..4968)
                     /locus_tag="KNP36_003579"
     CDS             complement(3298..4968)
                     /locus_tag="KNP36_003579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF and EAL domain-containing protein"
                     /protein_id="HBF0875405.1"
                     /translation="MREESNSLSLDHIEIFFELLSQSTEDYIFFWDINRNKFKISSAI
                     FDEFNLSKEIESDLVNCWSKIVYPDDVQIWKDDIQELLHGKKGEHNLEYRLINKYKEI
                     VWISCRGKVYVSDDPKTIFLVGRIKNIGEKNKFDSITGTWNREQFEHRMNYLIKEKIY
                     KNGAMFIMDIDNFKNINEKYGHSYGDKVLRAIATEVLEYLPKDVRLYRLDGDEFAFFY
                     PMCTKETIEKIYEKIQMYTNTQHEIESNKYYCTVTAGVAMYPEDGDNYLDLFKHADIA
                     LDIAKISGKNRIKFFSQELYENKLKVISMQQKLRECVENNFNDFELFFQPQVNAVTKE
                     VIGAEVLLRWHSSTYGEVSPVEFIPILEQSNLIIPVGKWIIKEAVKQCKEWHKINPDF
                     KISVNVSYIQLKEDFFRDFIVECLVEYQLRPEFLILELTENCWIPDINLLNDKFISLK
                     GIGVYIAIDDFGTGYSSLNYLKELSVNIIKIERSFVKNITYNSYEYTFLEYIIKLAHI
                     INLKVCVEGIESYEEYDIVKSLGVDIIQGFLFGRPVSASEFYKFQLSK"
BASE COUNT         1934 a          786 c          800 g         1944 t
ORIGIN      
        1 ttaattttaa tagtattatt tatcatttaa atctaaggag gaaatactta atgaatgcat
       61 ggcaaggatt taaaacagga agatggacta aagaaataaa tgttagagag tttatacaat
      121 taaactattc tccatatgag ggaaatgact ctttcttagc tggtgccact gaaaatacta
      181 aaaaattatg ggacgaagca atggtcctat ttaaaaaaga aagagaaaat ggtggtactt
      241 tagatgttga tacaaaaact gtttctggaa tagctgcata tgctccagga tatttagata
      301 aagaattaga aacaatagtt gggttacaaa cggatgcccc tttaaaaaga gctgtcatgc
      361 catatggtgg tataaagatg gttgaaaatt catgtgaagc ttttggatat gaattagacc
      421 cagaaataaa agatatattt actaaataca gaaaaacaca caaccaagga gtttttgatg
      481 tttatactcc agaaatgaga gctgctagaa aatctggtat aataacaggt cttccagatg
      541 cttatggtag aggtagaata attggtgact acagaagagt tgctctatac ggtgttgatg
      601 ctttaataga agataaaaat gagcaaaaga aatcattaga agtttcttgc atggatgagg
      661 aagttatcag attaagagaa gaaataactg agcaaatatc agctttaaat gaacttaaaa
      721 aaatggctga atcttatgga tttgatatat caaaaccagc aactaactca aaagaagctg
      781 tacaatggtt atactttggt tatttaggtg ctgttaaaga ccaaaatggt gctgcaatgt
      841 ctttaggtag aacatctact ttcttagata tatactttga aagagattta aaagctggaa
      901 tcgtaacaga agaagaatta caagagtata tggaccattt tgttatgaaa ttaagaatgg
      961 ttaagttcct aagaactcct gattacaata acctattctc tggagaccca acttgggtaa
     1021 ctgagtgtat aggaggtatg ggaatagatg gtagaacatt agttactaaa aactcattta
     1081 gaatgttaaa tactctatat acattaggac cttctccaga accaaactta acagttctat
     1141 ggtcaactaa attacctcaa ggattcaaag atttctgttc taaagtatct atagatacaa
     1201 gttcagtaca gtatgaaaat gatgatttaa tgagagcata ctggggagat gactatggta
     1261 tagcttgttg tgtatctgca atgagaattg gtaaacaaat gcagttcttt ggagctagag
     1321 ttaacttagc taaaacttta ttatacgcta taaatggtgg tgtagatgag aaatctggtg
     1381 ttcaagttgg accaagattt gaacctataa cttctgagta cttagattat gatgaagtta
     1441 tgagtaaatt tgaaccattc actgattggt tagcaacatt atatgtaaat actttaaatg
     1501 taatacatta tatgcatgat aaatattctt atgaagcatt agaaatggca ttacatgata
     1561 gagatatatt tagaactatg gcttgtggta tggctgggtt atcagtttgt gcagactcat
     1621 tatctgctat aaaacatgct aaggttaaaa ctattagaaa tgaacaagga atagctgttg
     1681 attttgaaat agaaggagat tatccaaaat acggaaataa tgatgataga gttgatagta
     1741 tagctgtaga gttagttgaa agctttatga ataaaataag aaagaataaa acttatagaa
     1801 attcttatcc aactcaatct atacttacaa taacttcaaa tgttgtttat ggtaagaaaa
     1861 ctggtaatac accagatggt agaagagctg gtgctccatt tgctcctggt gctaacccaa
     1921 tgcatggtag agatactaat ggtgctttag cttcattatc ttcagttgct aaattaccat
     1981 atgaacatgc tcaagatggt atatctaata ctttctctat agtacctggt gctttaggaa
     2041 aagatatgac tgaaagaata aacaatcttt ctgcaatgat ggatggatac ttcgctcaaa
     2101 atgctcatca cttaaatgta aatgtatttg atagagctac tttagaagat gctatggaac
     2161 atccagaaga atatccacaa ttaactataa gagtatctgg atatgcagtt aacttcataa
     2221 aattaactaa agagcaacaa ttagatgtta taaacagaac attccacggt aaaatggctt
     2281 agtctttaaa tttttatact ttaactaaga ttactactgt gtaaaaaata aaaataaaag
     2341 gctatcttat atttgaatta tttctggtat aagatggcct tttttagaga aatattataa
     2401 ctattgataa ggttattaaa atatattgtg aggtgaactc tatgattaag ggaaagatac
     2461 attctataga aacgtttggt actgtagatg gaccaggaat aagatatata ttattttttc
     2521 aggggtgtcc tcttagatgc aaatactgtc ataacaggga tacatgggat attaaatcag
     2581 gaaaagaata cacagttgat gaaataataa cggatgctct taagtatact tcttttatga
     2641 agttttctgg tggaggtata actgcctctg gtggtgaatc cactcttcaa ccagaatttt
     2701 taagtgaatt atttaaaaaa gcaaaagaaa atgatataca cacttgcttg gatacatctg
     2761 gatttgtaga tatagaaact atagacccag ttttagataa tattgatttg gttttacttg
     2821 atttaaaaca tatggttgag gaaaaatcta ttgatttgac tggtgttggt atggataagg
     2881 cattaaaact tgctagacac ttagaatcaa gaaatattcc tgtatggata agacatgttt
     2941 tagttcctgg cattactgat gatatagata atttagaaaa actaggtcaa tttgtagcta
     3001 cattgaaaaa tgtagaaaga tttgaattgc taccatacca ttctatggga atacacaaat
     3061 gggaaagttt aggtatcgat tatgaactaa aagatgttcc tgatgccact aaggaagatg
     3121 tccaaaaagc tagtgaaata atctctaaat ttggagtgaa agtatataat agttagtgta
     3181 gtatattaat cctttataga agacataaca aaatagggta aagtgtaaat ttttaataaa
     3241 cttcaaaact tccactttgc cctattttta tatactatat atctcatttt atatacatca
     3301 ctttgatagc tgaaatttat aaaattcaga ggcacttaca ggtcttccaa ataaaaaacc
     3361 ctgaataata tctacaccta agctttttac tatatcatac tcttcataag actctattcc
     3421 ctcaacacaa acttttaaat ttataatatg agctaattta ataatatatt caagaaaagt
     3481 atattcataa ctattatatg taatattctt aacaaaactt ctttcaattt ttattatatt
     3541 aacagacagt tctttaaggt aatttaaaga tgaatatcct gtaccaaagt catctattgc
     3601 aatatatact cctataccct ttaaactaat aaatttatca tttagtaaat ttatatctgg
     3661 tatccaacaa ttctctgtta attccaaaat taaaaattca ggtcttaatt gatactctac
     3721 taaacattct actataaaat ctctaaaaaa atcttccttt aactgaatat acgatacatt
     3781 tacagatatt ttaaagtctg gatttatttt atgccattct ttacactgtt ttacagcttc
     3841 ttttataatc cacttcccaa ctggtataat taaattactc tgttctagta ttggtataaa
     3901 ttcaacagga gatacttctc cataagtact cgaatgccat cttaaaagta cctctgcccc
     3961 tattacctct tttgtaacag catttacctg gggttgaaaa aacaactcaa aatcattaaa
     4021 attattttca acgcactctc ttagtttttg ttgcattgaa attaccttta gtttattttc
     4081 atagagctct tgtgaaaaaa acttaattct atttttacca ctaatttttg ctatatccaa
     4141 tgcaatatca gcatgtttaa ataaatctaa ataattatct ccatcttctg gatacatagc
     4201 aacgcctgca gtcactgtgc aatagtactt atttgattca atttcatgct gagtatttgt
     4261 atacatctgt atcttttcat atattttctc tatagtttct ttagtacaca tagggtaaaa
     4321 aaatgcaaat tcatctccat ctaacctata caatcttaca tcttttggaa gatattctaa
     4381 tacttcagta gcaattgcac gcaatacttt gtcaccataa gaatgtccat atttttcatt
     4441 tatattttta aaattatcaa tatccataat aaacatagca ccatttttat aaattttctc
     4501 ttttataaga taattcattc tatgttcaaa ttgttctcta ttccacgttc ctgtgataga
     4561 atcaaattta tttttttcac caatattctt tattctcccg actagaaata tagtttttgg
     4621 gtcatccgac acataaactt tacctctaca agaaatccat actatttctt tatatttatt
     4681 aatcaaccta tattctaaat tgtgctcacc tttttttcca tgtagtaatt cttgtatatc
     4741 atctttccat atttgaacat catccggata aacaatttta ctccaacaat tgaccaaatc
     4801 agattctatc tctttactta agttaaattc atcaaaaatt gctgaagaaa ttttaaattt
     4861 attcctattt atatcccaaa aaaatatata atcttctgta ctttgagata aaagttcaaa
     4921 gaaaatttct atatggtcta aacttaaaga gttcgattct tctctcatct tttcccccta
     4981 caatattact attagtgtag tttaatcaac aaaatatcct tatttagatt atactatttt
     5041 actaattttt tgtctcatca aacacatttc cccaacttta gttatcttat caaatctctt
     5101 actcttaact aagttttttg agattcataa agtaattttt ctataatcat tactggtgat
     5161 ttatttttac ctgctaaaac accatgttaa atcatttatt aaatcatttt ctcttaaaat
     5221 tctatttttc gttatataaa gagttatcag ttctttattc tataaaactt ttctattact
     5281 cttgaattta ttttattttt ttcttcgcct attctctttg gatttggtat tgcttttcta
     5341 tagattttgg caaagaagtg tctcttccta taatataaga ttttgatatt tcttcatcat
     5401 ctataaattt tttaataggg attatatcat tttttatatt tatttatata aatatttttt
     5461 gttt
//
LOCUS       DAEHWM010000158         5396 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.161, whole genome shotgun sequence.
ACCESSION   DAEHWM010000158 DAEHWM010000000
VERSION     DAEHWM010000158.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5396)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5396)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5396
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.161"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(43..699)
                     /locus_tag="KNP36_003580"
     CDS             complement(43..699)
                     /locus_tag="KNP36_003580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875406.1"
                     /translation="MKKGDFIWSGVLICIIAVLAIPSSREVFMEATGAHPYIGGFLKF
                     AVLATMGDLLGVRILYKDWKIPVGVFYRAIVWGIIGVVTTYGMSIYSSGVGQAQVDGM
                     LPFEGIAFANALFKSATMNILMSPTVFLFHKVMDCFIDKKYEVGKGIKVKLKDVVNIV
                     DWNAYLGFSVLKTIPFFWIPCHTIVFLFPAEYRVIASAFASIALGLILALANKSKVAV
                     "
     gene            complement(1811..2221)
                     /locus_tag="KNP36_003581"
     CDS             complement(1811..2221)
                     /locus_tag="KNP36_003581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003439126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875407.1"
                     /translation="MKIKKSLISAMMVSAMVLGGTGAVFANGNDSSNIALPKFESLIK
                     SGITDPTELEKYGVEHYTYEEYAKHIQELKDYAKDPNAVKDVSQKDLEETIKKMEQEL
                     EKIKTEGLKIMKPITIENEDGSQISIAYNYAAID"
     gene            complement(2437..3819)
                     /locus_tag="KNP36_003582"
     CDS             complement(2437..3819)
                     /locus_tag="KNP36_003582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003425112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M56 family metallopeptidase"
                     /protein_id="HBF0875408.1"
                     /translation="MFIKLLEMSFTSGVLLLIVIFIRACLFKKLPKKVFVLLWLIVLF
                     KLLIPVSLNSGFSIYSIIESTFDVELGNTSTENYTLKKASDSTGKNNSDEFEIMSNIE
                     NIMMLEMLGILSFIVTIMFSILLCFRYFKIINLFKTSIHIKNHEFIKKWMCKNSRFRR
                     FIVCISEFTRTPLTSGILKPRIILPKQMNYANNQTLDFVLTHEMVHINSFDNLLKLFM
                     LVALVVHWFNPLVWVMFFLLNKDIEFSCDEKVMSILGEEYRADYATTLISLAEENNPF
                     SMTICSGFGKTKIEKRIVNIMKFKKSTYVTFLVSTVLVCGTGLVFATENKEINEVESF
                     GLTKNEQSDKIGFSISSKSTDLYSPKVESDILVSKAKSDGETHFSTAKVSVIEFREHE
                     ESSMSKVTNSENSEETYVNKSSNSKDVLYTDSGEVSIERSGYNDNRFVILRKGNLLAV
                     NKEQYRTWIE"
     gene            complement(3830..4189)
                     /locus_tag="KNP36_003583"
     CDS             complement(3830..4189)
                     /locus_tag="KNP36_003583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875409.1"
                     /translation="MEIKLFDSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYT
                     VIKKLVSKGAIERIEPNFVCKALISKEEVQKQETETLINKMFGGSSEKFLSAFINKEN
                     LSSDEITKLKQIVEKLK"
     gene            complement(4394..5173)
                     /locus_tag="KNP36_003584"
     CDS             complement(4394..5173)
                     /locus_tag="KNP36_003584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HBF0875410.1"
                     /translation="MVSRQELKRVSKAQLSGNWGICAISMAVYIALIVLISIVGLPFE
                     PLTTIVVAVIAFCVSAGFTCMFLKITKDEKVKIGDIFVSGRIYLRSFGFYLFESIIVY
                     IYSFIITIIGAFLSFGVLLTSGAIEYLSSDNVGIGTIISTGITLVLIILVLMLPVYIL
                     LLYVSQATFLICEDKDNMGVFKSMGASLDMMKGNVLKLFVLNFSFIGWYILSIATLGI
                     GLLWLIPYVGVTNCNFYRQLVKENPDVEDILLDKEKSYTMY"
BASE COUNT         1878 a          941 c          483 g         2094 t
ORIGIN      
        1 ttattcctaa tttaaataat actactatct tcatcagtga acctaaactg caactttaga
       61 cttattagct aaagccaata ttagacctaa agctatagat gcaaatgcag aagcaattac
      121 tctatactca gcagggaata aaaatacaat tgtatgacat ggtatccaga aaaatggtat
      181 agtttttaaa acactaaaac caaggtaagc attccagtcc acaatattta ccacatcttt
      241 aagttttacc ttaatcccct ttccaacctc atatttttta tctataaaac agtccataac
      301 cttatggaat aaaaatacag ttggtgacat tagtatattc atagttgcac tcttaaatag
      361 agcatttgca aaagctattc cctcaaatgg aagcatacca tccacttgtg cttgacctac
      421 acctgatgag tagattgaca ttccatatgt ggtaactaca cctattattc cccaaactat
      481 tgctctataa aatactccta ctggtatttt ccaatcctta tacaaaattc taacaccaag
      541 taaatctccc attgtagcta atacagcaaa ctttaaaaaa cctccaatat atggatgtgc
      601 acctgttgct tccataaata cttctctact acttggtatt gctaagacag caataataca
      661 aataagaact ccactccata taaaatcgcc ttttttcata tttataaata ctatttaata
      721 tataaatagt tctcctttct attaaagatt tatttaattt acaatctatc tacaattatt
      781 tattaatcac ttattattag atattcattt tccatattta aatttattct atccctttat
      841 ctatttattt tcttactact ctatccacca ttatctatat atttatttta cgattactct
      901 ttcaccctaa ccctttaact atctattttt tcttactatt cttatccaca tcatccatat
      961 atttatttta cgattactct ttcactctaa ccctttaact atctattttt tctgatattc
     1021 ttatccacca tcatccatat atttatttta cgattactct ttcaccctaa ccctttaact
     1081 atctattttt ttctggtatt cttatctact attatctgta tatttatttt atgattactc
     1141 ttttaaccta ccccctatac tttatagtaa tatgttttta acctttttca ttattcccaa
     1201 tatgctttat aactacaaat actctccccc cttaaaaata ataataaaat taatcaataa
     1261 atttataatc atattattac tctatgtatt aagcaattac tatgccaata aactttgatt
     1321 tttttaaaca aatcttaaaa atcctaaaat gctaattttc tttaactttt aatgaatcta
     1381 atagataaca tttaattttc gttatatttt tcagaatatt tctattatta tttttaagaa
     1441 aaaaaaataa tgttaacatt tcttaacata cattaaaaaa tgttaacatt ataaattggg
     1501 tttaatactt ttactttgac tcgatttact tttattctac ttcttacttt atttttaact
     1561 tagactttat ttttttatta cttatttgag tcttatttat tttattctca ctccatatgt
     1621 tcaattacat ttgtctaaat tctttgatac ttttattaca taattttaac aagcttaagt
     1681 gttatttggg tagtgcagtt gataattatt taaataatca tcaactgcat gtttatatca
     1741 ttacagtagc ttaatgtatt taatcatact tacttaggat tttgaaatat cttagagatt
     1801 atatttaaca ttagtcaatt gctgcataat tgtaagcaat tgaaatttga gacccatctt
     1861 cattttctat agtgataggc ttcataattt ttaatccttc agtttttatc ttttctaatt
     1921 cttgttccat tttcttaatt gtttcctcaa ggtctttttg acttacatct ttgactgcat
     1981 tagggtcttt agcatagtct tttaattctt gaatatgttt agcatactct tcataagtat
     2041 aatgctcaac accatacttt tccaattcag tagggtcagt tattcctgat tttattagag
     2101 attcaaattt aggtaaagca atattagatg aatcatttcc atttgcaaat actgctccag
     2161 ttcctcctag taccattgca gataccatca ttgcacttat aagggatttt tttattttca
     2221 taaccaatct tcctttctta gagatttatt tgggtagtgt agtttaaaat gactattgca
     2281 atagttatca actacactct tagactatca cagtagtcat gtttatgtca agccttttta
     2341 aaaaactttt caataaaaaa tactatctca aagcaaaatt aattattttg agatagtatt
     2401 ttaattctaa atcttttata ttactaagat ttatggttat tctatccatg ttctatattg
     2461 ttctttatta actgctaaca aattcccttt tcttaatatg acaaagcgat tatcattata
     2521 gccacttcgc tcaattgaaa cttctcctga atcagtataa agtacatcct tactattact
     2581 agatttattt acatacgttt cttcactatt ctcagaatta gttactttgc tcatagatga
     2641 ttcttcatgc tctctaaatt caattacaga tacttttgcc gtactaaaat gagtctctcc
     2701 atcactttta gctttactaa caagaatatc agattctact ttgggagaat ataaatcagt
     2761 tgatttacta cttattgaaa atccaatttt atcactttgt tcattttttg ttaaaccaaa
     2821 agattcaacc tcattaatct ctttattttc tgttgcaaaa acaagacctg tcccacaaac
     2881 taatacagtt gaaactaaaa aagtaacata agttgatttt ttaaatttca taatattaac
     2941 tattctcttt tctatttttg tctttccaaa tccactacat attgtcattg aaaatggatt
     3001 attctcctct gctagactta ttagtgtggt tgcataatca gccctatatt cttcaccaag
     3061 tatactcata accttttcat cacaactaaa ttctatgtct ttatttagta aaaaaaacat
     3121 cacccaaact aagggattaa accaatggac aacaagagct acaagcataa ataactttaa
     3181 cagattatca aagctattaa tatgaaccat ttcatgagtt aaaacaaagt ctaaagtttg
     3241 attattagca taattcattt gctttggcaa aataattcgt ggttttaaaa taccagatgt
     3301 aagtggtgtc ctagtaaatt cagatatgca aacaataaat cttctaaaac ggctattctt
     3361 acacatccat tttttaatga actcatgatt ttttatatga attgaagttt taaaaagatt
     3421 aattatttta aaatatctaa agcataaaag tatgctaaac ataatagtaa ctataaaaga
     3481 caaaatgccc aacatttcca acatcataat attttcaata ttagacatta tttcaaattc
     3541 gtcagaattg tttttacctg tagagtcact agctttctta agagtataat tttctgttga
     3601 tgtattaccc aattccacat caaaagtcga ttcaattata ctataaatac taaaaccaga
     3661 atttaaactt actggtatta gaagtttaaa taaaacaatc aaccacaata atacaaatac
     3721 ctttttaggt aattttttaa ataaacatgc tcttataaaa ataactatta aaagtaatac
     3781 tccagaagta aaactcattt ctaacaattt aatgaacata aatcttacct cactttaatt
     3841 tttcaacaat ttgtttaagt tttgtaatct catcacttga aagattttct ttattaataa
     3901 aagctgaaag aaatttttct gaagaccctc caaacatttt attaattaaa gtttctgttt
     3961 cctgtttttg tacttcctct ttgcttatta aagctttaca aacaaaattc ggctcaattc
     4021 tctctattgc accttttgac actaattttt ttataacggt atacgtagtg tttctattcc
     4081 atcctgtttc ttcttttaaa atttttacta actctccagc cttgctttct cctctctccc
     4141 atagaacttc cattacttta agttctgaat caaataattt tatctccata taaaatcgct
     4201 cctcaaatat agttatcaca atagtcatta ctataataaa aaactatcat agtagtctat
     4261 actatgtcaa tcatttattt tttaataata aaaactgtct ttttaaaaaa ttcttataaa
     4321 agacagtttt atcaatgtta tactttaatg tttaattaaa gccatatttt atttaaatat
     4381 ataactatct atcttagtac atagtataag atttttcttt atctaatagt atatcctcta
     4441 catctgggtt ttcttttact aattgtctat aaaaattaca attagtaaca cccacatatg
     4501 gaattagcca tagtagacct attccaagag tagctattga aagtatatac catcctataa
     4561 agctaaagtt tagtacaaat aatttaagta catttccttt catcatatct aaactagcac
     4621 ccattgattt aaatacaccc atattatcct tgtcttcaca aattaagaaa gtagcttgag
     4681 aaacatataa tagcaatata taaactggta acataagaac aagtattata agaactagag
     4741 ttattccagt agaaataata gtccctattc caacattatc acttgataaa tattcaattg
     4801 ctccactagt aagtaaaact ccaaatgata aaaacgctcc tataattgtg attataaaag
     4861 aataaatata cacaataatt gattcaaata aataaaaacc aaaacttctt aaataaattc
     4921 tcccacttac aaagatatct cctatcttga ctttttcatc tttagtaatt ttcaagaaca
     4981 tacatgtaaa tcctgctgaa acgcaaaaag ctattacagc cactacaata gtagtcaatg
     5041 gttcaaaagg taatcctaca attgatatta atactatcaa tgcaatatat actgccatag
     5101 aaattgcaca tatcccccag tttccagata actgagcttt agatactcgt tttaattctt
     5161 gccttgatac cataaaaaac acccctttca ttttataaaa aaacttttaa aaatataaat
     5221 aatcttttaa cgtataatat taatatatca tattttcgac tatataagat acaattattc
     5281 accatgtttt atcaagatat gccataattg tattactagt tttatatagt caacattacc
     5341 aaatacatca aataaatttg attaattatt caacaagtaa taaaataatt tctatt
//
LOCUS       DAEHWM010000159         5394 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.162, whole genome shotgun sequence.
ACCESSION   DAEHWM010000159 DAEHWM010000000
VERSION     DAEHWM010000159.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5394)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.162"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            190..687
                     /locus_tag="KNP36_003585"
     CDS             190..687
                     /locus_tag="KNP36_003585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CarD family transcriptional regulator"
                     /protein_id="HBF0875411.1"
                     /translation="MYKIGESVMYPKEGACSVNDIVTKKINHEMQKYYELSVIFNSNL
                     KISIPVLNADRIGIRPVMDGNDVDNFIQSINKTDGVWIFDRKERLKLYQDKFHSGDVF
                     EIVKLIKMLMIQDSSKQLCSTDKEFLNKAQKFALSELAAAQCKSYTMVLEEMKKHILN
                     SKNTN"
     gene            complement(863..1111)
                     /locus_tag="KNP36_003586"
     CDS             complement(863..1111)
                     /locus_tag="KNP36_003586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875412.1"
                     /translation="MSRKAYEEALVELEKFIDERKEIIKSAEDCIDKYIVDRTLPFDY
                     KDKCVEWQQELLDIAEAQVLEANELSVLLQEKKELEED"
     gene            complement(1177..2193)
                     /locus_tag="KNP36_003587"
     CDS             complement(1177..2193)
                     /locus_tag="KNP36_003587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-hydroxy-acid oxidizing protein"
                     /protein_id="HBF0875413.1"
                     /translation="MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSS
                     FIENSKSLEKVKVNMRVIHDVSNPDTSIEMFGKKMSAPIFAAPVTGTTLNMGGKINER
                     DYIEPVVAGCVNSGIYAMVGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKI
                     RLAEEAGAFAVGVDIDACGLVTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVE
                     DALMAVEAGVDAIVVSNHGGRVLDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDV
                     LKMIGLGADAVLIGRPFVTASFGGATDGVETYVNKLQSELSSSMILTGCQTIKDIDGK
                     VIYK"
     gene            complement(2251..3018)
                     /locus_tag="KNP36_003588"
     CDS             complement(2251..3018)
                     /locus_tag="KNP36_003588"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HBF0875414.1"
                     /translation="MQDKSVREIKEIIETLEVEKYMEYIELLRVDERKSVQGLAIKLA
                     KKLDNIRKEEERLETINIFENEGYDKGYLYIGGIDEAGRGPLAGPVVASVVVFKKDTK
                     IEGVNDSKKLSEAKRDELFEVIKEEALDYGIGIVNNEEIDEFNILNATYMAMKKAINC
                     LKKAPDYLLVDAATIPGIDISQNPIVKGDSKSISIAAASILAKVTRDSIMYQYDRVYP
                     EYGFKSHKGYGTKEHYEAIEKYGITPIHRKSFLKNIL"
     gene            complement(3086..5275)
                     /locus_tag="KNP36_003589"
     CDS             complement(3086..5275)
                     /locus_tag="KNP36_003589"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylcobalamin-dependent
                     ribonucleoside-diphosphate reductase"
                     /protein_id="HBF0875415.1"
                     /translation="MKYIIKRDGTKELFSKSKIEDAVYKASINSEGGVDRELAYGISR
                     KIANDYNSMEKCLSVEEIQDIVEVLLMESNRKDIAKHYILYRERRSEIRTKAWEFDEL
                     QKSIWKNKYRHNGESFDEWIKRISNNSSRISKLIRQKKFLFAGRILANRGLQKEGKKV
                     TYSNCYVIEPPKDSIEDIFDTAKKLARTFSYGGGVGIDISKLRPKGAKVNNAAKHTTG
                     AVSFMELYSMTTGLIGQRGRRGALMISMDVNHPEIEDFIDIKTDLEKVTKANISVRVT
                     DEFMQAVREKKLYNCTFEVETTGEKIVKIVNAYDLFNKFVKNNWDYAEPGILFWDKIK
                     TYNFMSEDKNFCFSGVNPCAEEPLPSGGSCLLGSINLSEFIIQPFGEHATFDINKLKS
                     CVREAVVALNDVLDEGLNLHPLQEQRDSVHKYRQIGLGVMGIADMLIKMGIRYGSDES
                     LELCDLIGKTMLNEAVKQSALIAKEYGTFSEYKYENISKSKFFIENLNEDTKEMVKKY
                     GLRNSQLLTIPPTGSISTMIGISGGIEPIFNLSYIRKTESLHDEDVYYKVYTPIVKEY
                     MDKKGITDEECLPDFFVTAMNIGYEERINMQKVWQKYIDASISSTINIPFETTVEDVF
                     NIYIKAWEAGLKGVTIFRDGCKRSGILINEKKEENNKEDKKENSKKEYYKNNKKEKDN
                     KDEKAKEIINKNFEGDEKFVCPECGSEGIAHTGGCSICLKCGYSGCN"
BASE COUNT         1665 a         1026 c          529 g         2174 t
ORIGIN      
        1 aacatattaa attattttat cttatatttt tctctttagt ttcacacatc accaagtcta
       61 aactctatat tatatattaa tatttttgac ttgtcaagtt atttatgtta taatattaat
      121 cattagataa ttaaagcatt gtacctaagt tgcaatatct aaaattcaat ttggaggtat
      181 aactagcata tgtataaaat tggtgaaagt gtaatgtatc caaaagaggg agcctgctct
      241 gtaaatgata ttgtaacaaa gaaaataaat catgagatgc aaaaatacta tgaattaagt
      301 gtcattttta atagtaacct taaaatttcg attccagttc taaatgcaga tagaattggc
      361 atacgtccag ttatggatgg aaatgatgtt gataatttta tccaatctat taataaaaca
      421 gatggtgtat ggatttttga tagaaaagaa agacttaaac tgtaccaaga taaatttcat
      481 tcaggagatg tttttgaaat tgtaaaatta atcaaaatgc ttatgataca agacagttca
      541 aaacaattgt gtagcacaga taaggagttt ttaaataaag ctcaaaaatt tgctttatca
      601 gaattagctg ctgctcaatg taaatcctat acaatggtat tagaggaaat gaaaaaacat
      661 atattaaatt caaagaatac aaattaaacc agttttttaa actggtttta ttttttatac
      721 taatcatcca tgctacttta gcttatttta aactgcctaa tctaatatta ataaagttat
      781 ctcaattaga tagatgtatt ttattcaaat aaaaaaaact aagagtaaat catattactg
      841 atttactctt agctaataaa atttaatctt cttcaagttc ttttttctct tgtaataata
      901 cacttaattc atttgcttct aaaacttgtg cctctgcaat atcaagtaac tcttgttgcc
      961 attccacaca tttatctttg taatcaaaag gtagcgttct gtcaactatg tacttatcaa
     1021 tacagtcctc cgcactttta attatttctt ttctttcatc aataaatttt tctaattcta
     1081 ctaaggcttc ttcataagct tttctactca tataaattcc ccctttgtac aattattcta
     1141 cattaaaatg atttttcctc ttttttgtat aaaattttat ttgtatataa cttttccatc
     1201 aatatctttt atagtttgac atccagttaa tatcatagaa ctacttagct ctgattgaag
     1261 tttatttaca taagtttcta caccatcagt tgcaccacca aaagaagcag tcacaaaagg
     1321 tcttcctatt aatactgcat ctgcacctaa acctatcatt tttagtacgt ctaaaccagt
     1381 tctcactcca ccatctgcaa gtattgtaac tttaccttta acagcatcag caatttttgg
     1441 taaaacttca catgctcctg gtgtacagtc aagcactctt cctccatgat ttgatacgac
     1501 tattgcatcc acacctgctt ctactgccat taaagcatct tcaacagtca ttataccttt
     1561 caatataaat ggtagtttag tagactttac taactccttt atttgtttaa catttttagg
     1621 aagtactggt tttccatgta atgataaagt tactagacca caggcatcta tatcaactcc
     1681 aactgcaaat gcaccagctt cttcagctaa tcttatcttt tttataatat tttcattatc
     1741 ccaaggttta ataaatacaa ttccagctcc attatacttt ttgactacat ctaaattttc
     1801 cattaaaaaa gcatctactg ccgtatcacc aaccattgca taaataccac tattaacaca
     1861 tcctgcaact actggttcta tgtaatctct ttcattaatt tttccaccca tatttaaagt
     1921 agttcctgtt actggagctg caaatatagg tgcactcatt ttctttccaa acatctctat
     1981 agatgtatca ggatttgata catcatgtat tactctcata tttactttta ctttttctaa
     2041 actcttgcta ttttctataa aagaagaacc acttccttta cctcccatgc caggcacttc
     2101 acctgcacaa gcaaccccat tacaaacctt acaaacttta caacttccat ttaaattttc
     2161 tctagcactt tttaataatt cattatattc catctttaat cccccattaa ctatagtaat
     2221 ttatattata tacattatat catattatat ttacagtata tttttcaaaa aactttttct
     2281 gtggatagga gttatgccat atttttcaat agcttcatag tgttctttag ttccatatcc
     2341 tttgtgagat ttaaacccat attctgggta tactctatca tattggtaca ttatactatc
     2401 cctagtaact ttagcaagta tacttgctgc tgctattgat atagattttg aatctccttt
     2461 cacaattgga ttttgagata tgtcaatacc tggtattgtt gctgcatcaa ctaataaata
     2521 atccggtgct ttttttaaac aatttatagc ctttttcatt gccatatatg tagcatttaa
     2581 tatattaaat tcatctattt cttcattgtt tactatacct attccataat ctagtgcttc
     2641 ttcttttatt acttcaaaaa gttcatctct ttttgcctca ctcagtttct tagagtcatt
     2701 tacaccttct attttggtat cttttttaaa tactacaaca gaagctacaa caggtccagc
     2761 aagtggtcct cttcccgcct catcaattcc tccaatatat aaataacctt tatcatagcc
     2821 ttcgttctca aatatattta tagtttccaa tctttcttct tcttttctaa tattatccag
     2881 cttttttgcc agttttatag ctagaccttg tacagatttt ctttcatcaa ctcttaacag
     2941 ctctatatat tccatatatt tttctacttc taaagtctct attatttctt taatctccct
     3001 cacactttta tcctgcatac cattccctca tctttcgttt ttaaaaattt aatttttaaa
     3061 tatattaaaa ttttttaatt agagtttaat tgcatccact atagccacat tttaaacata
     3121 tactacatcc acctgtatgt gcaattcctt cacttccaca ctcagggcac acaaattttt
     3181 catctccttc aaaattttta tttattattt ctttggcttt ttcatcttta ttatcttttt
     3241 cttttttatt atttttataa tattcttttt tactattttc ttttttatct tctttattat
     3301 tttcttcctt tttttcattt attaaaattc cactcctttt acatccatct ctaaatattg
     3361 ttactccttt aagaccagcc tcccatgcct taatatatat attgaaaaca tcttcaactg
     3421 tagtttcaaa aggtatattt attgtagatg atatagaagc atcaatatac ttttgccata
     3481 ctttttgcat gtttattctt tcttcatatc ctatattcat agcagtaaca aaaaaatctg
     3541 gtaaacattc ttcatctgta atacctttct tgtccatata ctctttaaca attggagtat
     3601 atactttata atacacatcc tcatcatgca agctttcagt ttttcttata tatgaaagat
     3661 taaatatagg ttctattcca ccactgatac ctatcattgt agatatggaa cctgtaggag
     3721 gtatggttaa aagttgtgaa tttctaagcc catacttttt aaccatttcc ttagtgtctt
     3781 catttagatt ttctataaaa aacttagatt tagaaatatt ttcatattta tactcactaa
     3841 atgttccata ttctttagca attaatgctg attgcttcac agcttcattt aacatagtct
     3901 taccaattaa atcacatagt tctaaagatt catcagaacc atatcttatt cccattttta
     3961 taagcatatc agctataccc attacaccta aacctatctg tctatactta tgtacactat
     4021 ctctttgttc ttgtaatgga tgcaagttca atccctcatc taagacatca tttaaagcta
     4081 ctacagcttc tctaacgcaa gattttaatt tattaatatc aaaagtagca tgttcaccaa
     4141 atggttgtat tataaactct gacaagttta ttgagccaag tagacaactt cctccacttg
     4201 gaagtggttc ttctgcacaa ggatttactc ctgaaaagca aaagttctta tcttcactca
     4261 taaaattata tgtttttatt ttatcccaaa acaatatacc tggttctgca taatcccagt
     4321 tatttttcac aaatttatta aataaatcat aagcatttac tatcttaact attttttctc
     4381 cagtagtttc aacttcaaaa gtacaattat ataacttttt ttctcttaca gcttgcataa
     4441 attcatctgt tactcttaca gaaatatttg ctttagtaac cttctccaaa tctgttttta
     4501 tatctataaa gtcttctatc tctggatgat ttacatccat agaaatcata agagctcctc
     4561 ttctccctct ttgaccaatt aagccagttg tcatactgta aagttccata aaagagactg
     4621 ctccagtcgt atgttttgca gcattgttaa ctttcgctcc ttttggtctt agctttgaaa
     4681 tatcaattcc aactcctcca ccataactaa aagttctagc aagttttttt gcagtatcaa
     4741 atatatcttc tatgctatct tttggtggtt ctattacata acaattagaa tatgttactt
     4801 tttttccctc tttctgtaat cctctatttg ctaaaattct tccagcaaat agaaattttt
     4861 tttgtcttat tagttttgat attcttgaac tattatttga aattctcttt atccattcat
     4921 caaaactctc accattatgt ctatacttgt tcttccatat tgatttttgt aattcatcaa
     4981 actcccaagc tttagtcctt atttcagagc gtctttctct atataatatg tagtgttttg
     5041 ctatatcttt tctatttgat tccataagta gtacttcaac tatatcttgt atttcttcta
     5101 cggataagca tttttccata gaattatagt cattagctat ttttcttgat ataccatatg
     5161 ccaactctct atctactcca ccttcactat ttatactagc tttatagaca gcatcttcaa
     5221 tcttactttt actaaaaagt tcttttgtac catctctttt tattatgtat ttcattttta
     5281 aacctccaat aaattagtat taaattaata cacacattaa ctataactct aaacaaactt
     5341 tttatatatt tgtatatttt catattaatt atctaacata atatatatta tact
//
LOCUS       DAEHWM010000160         5352 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.163, whole genome shotgun sequence.
ACCESSION   DAEHWM010000160 DAEHWM010000000
VERSION     DAEHWM010000160.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5352)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5352)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5352
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.163"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(204..1388)
                     /locus_tag="KNP36_003590"
     CDS             complement(204..1388)
                     /locus_tag="KNP36_003590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HBF0875416.1"
                     /translation="MLSKRLNFITPSYTIGISSKVKEMESNGVKVINLSIGEPDFNVP
                     NNAKSYGIDSLNKDYTKYDLVPGLKILREEICKKLIEENNCNYSIDEIVVSSGAKNSI
                     TNTLLALTDEGDEVLLPKPYWVSYPEMVKLVNAVPVFIDTKKENGFKLTKDELEKSIT
                     DKTKILVINNPSNPTGSVYTKDELIEIVDVCIQNKIYILADEIYEKICYTGEFTSIAS
                     LSEEAKDITITINGFSKSAAMTGLRLGYTASNKTIAKAMSSIQGHLISHPSLTAQYIA
                     YGALKDCSIDIDNMVKTYKSRRDLIKSKLDSIDNVGYVNPNGAFYIFIDLSKVSEKFE
                     YKDSFSIEFCNQFLEEYNVAVVPGIAFGMDKYIRISYACSENTFLSGLDKLKEFVYKI
                     MA"
     gene            1761..4112
                     /locus_tag="KNP36_003591"
     CDS             1761..4112
                     /locus_tag="KNP36_003591"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside triphosphate reductase"
                     /protein_id="HBF0875417.1"
                     /translation="MVEFVKKRDGRVIPFNEDRITRAIFLAATNVAEREGIVPDYKLS
                     EQLTQEVIKFLNHKYSESVPSVEDIQDSVVKVLIETGHAKTSEEYIIYRTERSRIRNS
                     KTRLMKAIEEITFEDAEDADIKRENANINGNTAMGTMLQYGSTVSKEFCKTHILKPEH
                     SFAHDNGDIHIHDMDFLNMGTLTCCQIDVKKLFNGGFSTGHGFLREPQDIISYGALAA
                     IAIQSNQNDQHGGQSIPFFDYGLAEGVYKTFKKFYIGNLAKALKLFKGIENNDVIKNI
                     VYNTEKETNQKVGLKRDELYLNLEKEKLIQTFDIDDELVNKMQNFAFEESYRETDKKT
                     YQSMEAFIHNLNTMHSRAGAQVPFSSVNFGTDTSEEGRMVTKNLLLSQERGLGNGETP
                     IFPILIFKVKEGINLNPEDPNYDLFKLSCRVSAKRLFPNFSFLDAPFNAKYYKKGEPD
                     TEATYMGCRTRVLSNVCGSETVSGRGNISFTTVNLPRLGIKHGIINNEKANLDGFFEE
                     LDEKINLIIEQLLERLEVQGNKKMKNFPFLMGQGVWKGSDDLGPEDTLKEVIKQGTLT
                     IGFIGLAECLIALIGKHHGESKEAQELGLKIVSHMRHKMDEATDKYKLNFSLMGTPAE
                     GLSGRFTKIDKKVYGEIKGITDKEYYTNSFHVPVYYNISAYDKIEIEAPYHELTNAGH
                     ITYVELDGDPSDNLEAFETVIKAMKDLGIGYGSINHPVDRDPICGFSGVITSNICPVC
                     GRNEDESDIKFERIRRITGYLVGTVDRFNNAKKAEVRDRVKHR"
     gene            4134..4673
                     /gene="nrdG"
                     /locus_tag="KNP36_003592"
     CDS             4134..4673
                     /gene="nrdG"
                     /locus_tag="KNP36_003592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HBF0875418.1"
                     /translation="MKIRMSSTISYDSIVDGPGLRMVIWTQGCIHNCKECHNPQTHDL
                     CGGFYMDTEEIINKVKSLKLQKGITLSGGEPFLQPEPLEEIAREAKINGLDVWSYTGF
                     TFEQLLDKKNRAYFKNLNLLKQIDILVDGKFIAEKKDISLKFRGSSNQRIIDVQKSLK
                     YKKVFLVEQYMKDDLSIAE"
BASE COUNT         2097 a          598 c          851 g         1806 t
ORIGIN      
        1 ttataataaa tttagaattt aacttatata gtttaatttg ataatttgat gaaaaaaata
       61 aaagacttac tgatttttaa atctataggt cttttatttt ttatctaaca tttaaattaa
      121 gttgttgaat atatcttata ttacttacct tatatattaa ttaccattaa tacattatat
      181 ctaattacta ttcatctaaa ttattatgcc attattttat atacaaattc ttttaattta
      241 tctaatccag ataagaaagt attttcactg caagcatagg atatacgaat atatttatcc
      301 ataccaaatg ctatgccagg aacaactgca acattatatt cttctaaaaa ttgattacaa
      361 aattctatag aaaaactatc tttatattca aatttctcag atactttaga aagatctata
      421 aatatataga atgcgccatt tggattcaca tatcctacat tatcaataga gtctagtttt
      481 gatttaatta aatctcttct tgatttatat gttttaacca tattgtctat gtcaattgag
      541 caatctttca aggctccata ggctatgtat tgtgctgtta gacttgggtg agatataaga
      601 tgtccttgta tagaactcat tgctttagca atcgttttat tagatgcagt atatcctaat
      661 cttaatccag tcattgcagc tgacttagaa aaaccattta tagttattgt tatatcttta
      721 gcttcttcgc ttaatgatgc aattgatgta aattcaccag tgtagcatat tttttcatat
      781 atttcatctg ctaaaatata tattttattt tgtatgcata catctactat ttctattaat
      841 tcatcttttg tataaacact accagtagga tttgaaggat tgtttattac aagaattttt
      901 gttttatctg ttatagattt ttcaagttca tcttttgtta acttaaatcc attttctttt
      961 ttagtatcaa taaaaactgg aacagcatta actaacttaa ccatttcagg ataactaacc
     1021 caataaggct ttggtaataa gacttcatct ccttcgtctg ttaaagctag taaagtattt
     1081 gttattgagt tttttgctcc acttgataca actatttcat ctattgaata gttacagtta
     1141 ttttcttcaa taagtttttt acagatttcc tctctaagta tttttaatcc tggaactaaa
     1201 tcatatttag tgtaatcttt atttaaagaa tcaataccat aagattttgc gttattaggt
     1261 acattaaaat cgggttctcc tatactaaga tttattactt taactccatt actttccatt
     1321 tctttaactt tagaactaat acctattgtg taggatggtg ttataaagtt tagtcttttt
     1381 gataacataa aatgcctcct tttaaattat tatttatatt atacgacaaa tttaaagaat
     1441 ttacataagg aaatttgtag atatatacat taatatatat aatagcctac actttttgcc
     1501 taaaattagt gtaaaaaaaa gagaaaaaaa ttttaacttt caaagttgtt agaaacgcta
     1561 ctgttcaaaa tatccacata gtatttgcaa tgatttgcgc aagtttgact attatgtaca
     1621 aatttggtaa tcttaatata gcaattatta agataatccc tttaacttag ttgaagggga
     1681 tttttttaga cttaacatac tacatatagt ggtatgggga ttaataaaat acaatatata
     1741 gtaacaggag gtttttttaa ttggttgaat tcgtaaaaaa aagagatgga agagtaattc
     1801 catttaatga agatagaata acaagagcta tatttttagc agcaacgaat gttgcagaaa
     1861 gagaaggaat agtacctgat tataaattat ctgagcaatt aactcaagaa gtaataaagt
     1921 ttttaaatca taaatactca gaatcagttc caagtgttga agatatacaa gattctgtag
     1981 ttaaggttct tatagaaact ggccatgcaa aaactagtga agaatatata atatacagaa
     2041 ctgaaagaag tagaataaga aattcaaaaa caagattgat gaaggcaata gaggaaatta
     2101 cctttgaaga tgcagaagat gctgatataa aaagagaaaa tgcaaatatt aatggtaata
     2161 cagcaatggg aactatgtta caatatggaa gcactgtatc taaagaattt tgtaaaacac
     2221 atatattaaa accagagcat tcttttgctc atgataatgg agatatacac atacatgata
     2281 tggatttttt aaatatggga acattaactt gttgtcaaat agatgttaaa aaactattca
     2341 atggtggatt ttcaacagga catggctttt taagagagcc acaagatata ataagttatg
     2401 gtgcattagc tgcaattgct atacaaagca atcaaaacga tcaacatgga ggtcaaagta
     2461 taccattttt cgattatgga ttggctgaag gtgtatataa gacatttaag aaattctaca
     2521 taggaaattt agctaaagca ttgaagttat ttaaaggaat tgaaaataat gatgtgataa
     2581 agaacatagt atataataca gagaaagaaa caaatcaaaa agttggtctt aagagagatg
     2641 aattgtatct aaacttagaa aaagagaaat taatacagac ttttgatata gatgatgaac
     2701 ttgtaaataa gatgcaaaac tttgcatttg aagaatcgta tagagaaact gataaaaaaa
     2761 catatcaatc tatggaagca tttatacaca atctaaatac aatgcactct agagcaggtg
     2821 cacaggtacc attttcaagt gtaaacttcg gaacagatac ttctgaagaa ggaagaatgg
     2881 taactaagaa tcttctatta tctcaagaaa gaggtttagg taatggagag acaccaattt
     2941 ttccaatttt aatatttaag gtcaaagaag gcataaattt aaatcctgaa gaccctaatt
     3001 atgatttatt taaattatca tgcagagtat cagctaaaag actattccct aattttagct
     3061 ttttagatgc gccttttaat gcaaaatatt ataaaaaagg tgaaccagat acagaggcta
     3121 catatatggg ttgtagaaca agagtactta gtaatgtgtg tggttcagaa acagttagtg
     3181 gtagaggaaa catatctttt actacagtaa atttaccaag attgggtata aaacatggta
     3241 ttataaataa tgaaaaggct aatttagatg gtttctttga agaattagat gagaagataa
     3301 acttaattat agaacaatta ttggagcgcc ttgaggtaca aggaaataaa aagatgaaga
     3361 attttccatt cttaatgggg caaggtgtat ggaaaggttc tgatgattta ggaccagaag
     3421 atacactaaa agaagtaata aaacaaggaa cattgacaat tggatttata ggtttagcag
     3481 agtgccttat tgctcttata ggtaaacatc atggagaaag taaagaagct caagaattag
     3541 gattaaaaat agtgtcacat atgagacata aaatggatga agcaacggac aaatataaat
     3601 taaatttctc cttaatgggt actccagcag aaggtctttc aggtaggttt actaaaatag
     3661 ataaaaaagt ttatggagaa attaaaggta tcacagataa agaatattat actaattcat
     3721 tccatgtacc agtttattac aatataagtg catatgataa aattgagata gaagctccat
     3781 accatgaatt gactaatgca ggtcatataa catatgtaga gttagatgga gatccatctg
     3841 ataatttaga agcttttgaa actgttataa aagctatgaa agatttgggt ataggatatg
     3901 gaagtataaa tcatcctgta gatagagacc caatatgcgg tttttcaggt gtaataacaa
     3961 gtaatatatg ccctgtatgt ggaagaaatg aagatgaaag tgacatcaaa ttcgaaagaa
     4021 taagaagaat aacaggatac ttagttggta cagttgatag atttaataat gctaaaaaag
     4081 cagaagtaag agatagagta aaacatagat agttttattt gggggaataa gttatgaaaa
     4141 taagaatgtc atctactata agttatgaca gcatagttga tggaccagga ttaagaatgg
     4201 taatatggac tcaaggatgt attcataatt gtaaagagtg ccataatcct cagacacatg
     4261 atttatgtgg aggattttat atggatacag aagaaattat aaataaagtc aaatcattga
     4321 aattacaaaa aggcattacg ctatcaggag gagaaccatt tttacaacca gaaccattag
     4381 aagaaatagc aagagaagct aaaataaatg ggttagatgt atggtcatat actggattta
     4441 cgtttgaaca actgttagat aaaaaaaata gagcgtattt taaaaattta aatttactaa
     4501 agcaaattga tattttagtg gatggaaaat ttatagctga aaaaaaagat ataagcttaa
     4561 agtttagagg gtcatcaaat caaaggataa ttgatgttca aaaaagtttg aaatataaaa
     4621 aagtgttttt ggttgagcaa tatatgaagg atgatttatc tatagcagaa taaaatataa
     4681 ataaacagga ttaaatatat gcatatattt aatcctgttt attttcatat aatatttcaa
     4741 gcttgtataa tgtaacaatt aaaccaaaag actcattgta tatttgaaat taagtttttt
     4801 atagtttata ggtgttttat gtggattacg aatgatatag tattgataca ttatttaata
     4861 gattcttatg ccaagaaaca attaatttat agaaattctt aattgttaca atataaatat
     4921 ctagataagt tataagatac tgataaataa tttataaagt ttattaatct aatattgtgt
     4981 gtgaatatta agtggtcaag tagtctaaaa aatgaaaaag atttaaaaaa gtgttttaac
     5041 taaacacata agtgttaaat tcatgtataa gtataggtta gatacataag aaataattat
     5101 gtaatatcta tctttgtaaa aaaatattaa attttgtaat ttgtggataa atatgtttat
     5161 aatgtggata atatttaatg taataagtta aagcaatatg aatcaactgt ttataatgtg
     5221 gataatatta taaatgtatg aataattgca gtatttaaaa acaaaaaaag ttaaaaaagt
     5281 tgttgactct aaaagaaaaa gttggtatag taatacttgt cctcaagaaa agggcaaaca
     5341 aataaagcat aa
//
LOCUS       DAEHWM010000161         5292 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.164, whole genome shotgun sequence.
ACCESSION   DAEHWM010000161 DAEHWM010000000
VERSION     DAEHWM010000161.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5292)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5292)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5292
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.164"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(56..628)
                     /locus_tag="KNP36_003593"
     CDS             complement(56..628)
                     /locus_tag="KNP36_003593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000265278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese catalase family protein"
                     /protein_id="HBF0875419.1"
                     /translation="MWIYQKTIQHPVNIKTCDPRMAKFLITQFGGPNGELAASLRYLS
                     QRYTMPTGNMRALLTDIGTEELAHVELICTMVYQLTSDASPEELKAAGLGSNYAQNGY
                     GIYPTDSNGVPFDVRPIAVMSNPVTDLHEDMAAEQKALATYYQLINLTDDVDVIDVLK
                     FLGQREIIHYQRFGEALMDAYELEESQKMF"
     gene            complement(657..923)
                     /locus_tag="KNP36_003594"
     CDS             complement(657..923)
                     /locus_tag="KNP36_003594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat protein CotJB"
                     /protein_id="HBF0875420.1"
                     /translation="MKDSSRAELMRKVQETSFACVDMNLYLDNHPDDKNAINTYNSLC
                     NQFAQARYAYENKYGPLTNFGYAPSRCPWQWADQPWPWDREFNY"
     gene            complement(923..1132)
                     /locus_tag="KNP36_003595"
     CDS             complement(923..1132)
                     /locus_tag="KNP36_003595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="spore coat associated protein CotJA"
                     /protein_id="HBF0875421.1"
                     /translation="MENKTRDIKKNCGPSLARPYINNQIFTEMYCLSDALKFGTIFPE
                     LNLLESEMYNKELYAKPKKYRGGRR"
     gene            1401..2261
                     /locus_tag="KNP36_003596"
     CDS             1401..2261
                     /locus_tag="KNP36_003596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011986089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiocytidine(32) synthetase TtcA"
                     /protein_id="HBF0875422.1"
                     /translation="MSELSGKGCEIIVPFEERLPVRDIEKSIIKKYRKNLWSKFMKAI
                     RDYKLVEEGDKIAVAISGGKDSILMAKMFQELKKHGQVNFDVEFIAMDPGYHANIRQL
                     LIDNCEYLNIPIHLFDSRIFEIADEIAKDYPCYMCARMRRGALYSKAEELGCNKLALG
                     HHYDDVIETTMLNLLCAGNFKTMLPKLNSTNFEGIKIIRPLYYIREEHIIRFIQNSGI
                     WPLNCACMVAAKKTGNKRYEIKDLIKSLESNFKNVEKSIFKAAENVNLDSVLGWQKDG
                     EKHSFLENFE"
     gene            2309..3337
                     /locus_tag="KNP36_003597"
     CDS             2309..3337
                     /locus_tag="KNP36_003597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HBF0875423.1"
                     /translation="MKRVYIDFEMNMPNSKSKRAVFNSDIIAIGAVVYDEKTKNIDKF
                     KSLIRPVSNEELYPHIQELTHISSEELKSAPSYEEVMRKFKKWLGIFSDIKGIYTFGN
                     LDLTCFNNTDMRSAKKNNHPRFVNNIRDLFVDIKEKYINCGMRCMNYISLKNLLEFVN
                     LEFSGDAHDPLNDAYNLFILDEAITNNVDIQNLLIIRDIIRPPFNDINSNLDNCFNKF
                     KESLYKKEGNYNIVDFSVEIIKTVRMYLLTIIDVNIQNLEIMKDISKKMDTIDKLKDI
                     EEGYFYLLEDVYFDMKDVLEDLMLYRMNEDEYKYEIKNIIKMFDEDLDNEKIYINKCN
                     NLNVVNKI"
     gene            3708..4214
                     /locus_tag="KNP36_003598"
     CDS             3708..4214
                     /locus_tag="KNP36_003598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase"
                     /protein_id="HBF0875424.1"
                     /translation="MGFREVKIEELQFNPFTKIGKEWLLITAGDSEKFNTMTASWGGV
                     GVYWGKNVVTTYIRPQRYTKEFVDSNDTFTVAFFDETYREALNICGTISGRDINKIEK
                     AGLTPYFVDDTVAFEEANMIIVCKKLYHGNMPPENFDAKENDKKWYPEKDYHTMYISE
                     IIKVLVKE"
     gene            4627..>5292
                     /locus_tag="KNP36_003599"
     CDS             4627..>5292
                     /locus_tag="KNP36_003599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875425.1"
                     /translation="MENITSYFTTILCVFICLSSVFIFTQLARVFINKKKINQKIKSR
                     NGFRYDRDFIEARREEIHIKDNNNNKNKSNNKKLKGEKVFKYDNGDLYKGEFVDGKKN
                     GFGIYIFSSKEKYEGLWKDDKMHGIGKYTYRDGSIYTGEFKYGLKNGLGKLTYPNNDI
                     YKGYFLDNKKNGKGVLYKNDGNKQAGIWEDDEQCKSLDFKDLNNNKINNVYQNRLNNN
                     KLKV"
BASE COUNT         2131 a          526 c          840 g         1795 t
ORIGIN      
        1 aacacaacag taaattataa attatcaaat aataatagtt atacaaataa aaattttaga
       61 acattttttg agattcttct aactcgtaag catccattaa agcttcacca aatctttgat
      121 agtgaattat ttctctttga cccaagaatt ttaatacatc tataacatca acgtcatctg
      181 ttaggtttat aagttgataa taagttgcaa gtgctttttg ttcagctgcc atatcctcat
      241 gtaaatcggt tacgggattt gacataactg ctataggtct tacatcaaat ggaacaccat
      301 ttgaatctgt tggataaatt ccatatccat tttgagcata gtttgaacca agacctgcag
      361 cttttaactc ttctgggctt gcatcagaag ttaactgata aaccatagta catataagct
      421 caacgtgagc tagttcttct gtaccaatat ctgttaaaag tgcacgcata ttaccagtag
      481 gcattgtata tctttggctt aaatatctta aagatgcagc aagttctcca tttggcccac
      541 caaattgagt tataagaaat ttagccattc tagggtcaca agtttttata ttaactgggt
      601 gttgtatagt tttctgatat atccacatga attttcaatc ctccaatact tgatgtctaa
      661 taattaaatt ctctgtccca aggccaaggt tggtcagccc attgccaagg gcatctactt
      721 ggagcatacc caaagttagt taaaggaccg tatttatttt cgtaagcata tctagcttgc
      781 gcaaattgat tacataatga attataagtg ttgatagcat ttttatcatc agggtgattg
      841 tctaaatata agttcatatc aacacatgca aaagatgttt cctgaacttt tctcataagt
      901 tcagctctag atgagtcttt cattatcttc tacctcctct atattttttt ggcttagcat
      961 ataattcttt gttgtacatt tcagactcta gtaagtttag ttctggaaat atagttccaa
     1021 attttaatgc atcagaaagg cagtacattt ctgtgaaaat ttgattatta atgtatggtc
     1081 tagccaaaga tggaccacaa ttttttttga tatctctagt cttattttcc aagatgaaaa
     1141 cctccttgtt gtaaatagat aggtaactct atctagtgta taatattcaa tcatttaaaa
     1201 atcgttacta ataataaaat attaaatgag aaaaataaaa aagataataa aagaaagagg
     1261 ttatttatgt tattataagt ttatgtgtta ttgtaaacta taaattattt agtaaaatta
     1321 aagtaaaaat tatagtattt tgtggatgaa ggtagacttt tttgtaaaat attattaaca
     1381 taaatatacg aggtgattag atgagtgaac tatcaggaaa aggctgtgaa attatagttc
     1441 cttttgagga aagacttcca gtaagagata tagaaaaaag tataataaaa aaatatagaa
     1501 aaaatttatg gtctaagttt atgaaggcaa taagagatta taaattggtt gaagaaggtg
     1561 ataagatagc tgtagcgatt tctggtggaa aagacagtat tcttatggct aaaatgtttc
     1621 aagagttaaa aaaacatgga caagttaatt ttgatgttga atttattgct atggaccctg
     1681 gatatcatgc aaatataaga caattactta tagataattg tgagtatcta aatataccaa
     1741 tacatttatt tgattcaagg atatttgaga tagcagatga aatagcaaaa gattatccat
     1801 gctatatgtg tgcaagaatg aggagaggag cattatattc aaaggcagaa gaactagggt
     1861 gcaacaaact tgcattaggt catcattatg acgatgtaat agagacaaca atgcttaact
     1921 tattgtgtgc tggaaatttt aaaacaatgc ttcctaaact taattctact aattttgaag
     1981 gtataaaaat tataagacca ctttattata taagagaaga acatattata agatttattc
     2041 aaaatagtgg tatatggcca ttaaattgtg catgtatggt tgctgctaaa aaaacaggta
     2101 ataaaagata tgagataaaa gacttaataa agagtttaga atcaaatttt aaaaatgtag
     2161 aaaaatctat atttaaggcg gcagaaaatg taaatcttga ttcagtactt ggttggcaaa
     2221 aagatgggga gaaacattct ttcttagaaa attttgaata aaaatagtta aaaagaatca
     2281 ctataaacaa ttggaaaggg tgtttatatt gaaaagagta tatatagatt ttgaaatgaa
     2341 tatgccaaat tctaaatcaa aaagagcagt atttaattct gatataattg caattggagc
     2401 agttgtgtat gatgaaaaaa caaaaaatat tgataaattt aaatctttaa taagaccagt
     2461 aagtaatgag gagttgtatc ctcatataca agaattaaca catatatctt ctgaagaatt
     2521 gaagagtgca ccaagttatg aagaggtcat gagaaagttt aaaaaatggc ttggcatatt
     2581 ttctgatatt aaaggaatat atacttttgg taatttggat ttgacatgtt tcaataacac
     2641 agatatgaga agtgctaaaa aaaataacca tccaaggttt gtaaataaca ttagagattt
     2701 atttgtagat ataaaagaaa aatatataaa ttgtggtatg agatgtatga actatatatc
     2761 attgaaaaat ttacttgaat ttgttaactt agagtttagt ggagatgccc atgacccatt
     2821 aaatgatgca tataatttat ttattttgga tgaggcaatc acaaataatg tagatataca
     2881 aaatctttta ataatacgtg acataataag accaccattt aacgatataa attctaattt
     2941 agataattgt tttaacaaat ttaaggagtc attatataaa aaagaaggaa attataatat
     3001 tgtagatttt tctgttgaaa taataaaaac tgtgagaatg tacttattaa caatcataga
     3061 tgtaaatata caaaatttag aaattatgaa agatataagt aaaaaaatgg atactataga
     3121 taaattgaaa gatatagagg aaggctattt ttatttatta gaagatgtgt acttcgacat
     3181 gaaagatgta ctagaagatt taatgcttta tagaatgaat gaagatgagt acaagtatga
     3241 gataaaaaat ataataaaaa tgtttgatga agacttagat aatgaaaaaa tatatataaa
     3301 taaatgtaat aacctaaatg ttgttaataa gatataagaa attataaata atagagtaga
     3361 acttgacaat tataacaatt ttttataaaa ctgaatcaag ataaaattaa attaatataa
     3421 aaataatata caataaaaaa tgtagagaga tacttacttt ctacattttt ttattgtata
     3481 ttgctttagg tttaaaaata tattatatac tttataatca atatatttta tctatatttt
     3541 acacttataa aatatgaaaa ctacttattg cgaaagtaat tgatttgttg tattataatt
     3601 tacatgaatt atgtaggaca atcaaaagtc agtattataa gagtacatat attcaaattt
     3661 ttaacaatta atttatataa ttaaaaaatg aagggtagga tgaagtcatg ggttttagag
     3721 aagtaaaaat tgaggaatta cagtttaatc catttactaa gattggcaaa gaatggttac
     3781 ttataacagc tggtgattca gaaaagttta acacaatgac tgctagctgg ggtggtgttg
     3841 gagtctattg gggtaaaaat gttgttacaa cttacataag accacagaga tatacaaaag
     3901 aatttgtaga tagtaatgat acatttacag ttgccttctt tgatgaaacg tatagagagg
     3961 ctttaaatat ttgtggtact atttctggta gagatataaa taaaatagaa aaagcaggac
     4021 ttacaccata ttttgtggat gatacagtag cttttgaaga agctaatatg attatagtat
     4081 gtaaaaagct atatcatggt aatatgccac cagaaaactt tgatgctaaa gaaaatgata
     4141 aaaaatggta tccagagaaa gactaccata ctatgtacat ttcagaaatt ataaaagttc
     4201 ttgtaaaaga ataattataa taaaaaatat atgaaaagaa cttattataa gtaaatgact
     4261 gtgctttctt atctgatatc taagtagatg ctagtaacta aataaatatt aattttaaat
     4321 aaatactatt ataaaaaaga tgaactatat ttactatagt tcatcttttt atttatataa
     4381 gcacttatat aagtagagat ttatttgaat aaaagtattt atttgaaata tttgagtata
     4441 ctttataagt atttttatgc taactagaaa cacttaattt atggcatttg tatttgattt
     4501 attttaatgt aaataatttc aaagttaatt ttattcaata tagtactata aaagtataaa
     4561 taacatttaa taaaaatata tattatatta ggtattttaa ataaattttt taaagggtga
     4621 ttttttatgg aaaatataac tagttatttt acaacaatac tatgtgtatt tatatgctta
     4681 tcatctgtat ttatatttac tcaactagct agagtattta ttaataagaa gaagattaat
     4741 caaaaaatta aatcaagaaa cggatttagg tatgatagag attttattga agccagaaga
     4801 gaagaaatac atataaagga taacaataat aataaaaata agagtaacaa taagaaatta
     4861 aagggagaaa aagtatttaa atacgataat ggtgatttat ataaaggtga gtttgttgat
     4921 ggaaagaaaa atggatttgg gatatatatt ttttcaagta aggaaaagta tgaaggatta
     4981 tggaaagatg acaagatgca tggaatagga aaatatactt atagagatgg ttcaatatat
     5041 acaggtgaat ttaaatacgg attaaaaaat ggtttgggaa aattaacata tcccaataat
     5101 gacatttata agggatattt tttagataat aagaaaaatg gtaagggtgt attatataaa
     5161 aatgatggaa ataaacaagc aggaatatgg gaagatgatg aacaatgtaa aagtttagat
     5221 tttaaagatt taaataataa taaaataaat aatgtttatc aaaatagatt aaataacaat
     5281 aaattaaaag tt
//
LOCUS       DAEHWM010000162         5010 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.165, whole genome shotgun sequence.
ACCESSION   DAEHWM010000162 DAEHWM010000000
VERSION     DAEHWM010000162.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 5010)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5010)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5010
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.165"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            101..712
                     /locus_tag="KNP36_003600"
     CDS             101..712
                     /locus_tag="KNP36_003600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA pyrophosphatase"
                     /protein_id="HBF0875426.1"
                     /translation="MINDIKNKFKNYKPYINGYKNMKRASVLIPIVEINNTHYILFEV
                     RSKNLKHQPSEISFPGGKIESGETPYEAVIRETCEELGTFSDNIEVISSLDLLITPVK
                     FIIHPYLGYIKNINNLNINKDEVDHTFLVPIKYLLENPPNTYSNTVKVFPDENLPYGS
                     IPNQKDYKFESGSYPILFYKYKDYVIWGMTAKILENFLNFLSE"
     gene            1010..1348
                     /locus_tag="KNP36_003601"
     CDS             1010..1348
                     /locus_tag="KNP36_003601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3784 domain-containing protein"
                     /protein_id="HBF0875427.1"
                     /translation="MFAVGFVVIIALAFFILSVLLFNGKASMLLAGYNSMSKKEKARY
                     DKKKLCRSSSIVTFIVSIMLFIMAFLGYRIESGQMDEKKMVPFSIIFIIVILSSVFFN
                     ILYSNKKCKK"
     gene            complement(1755..3191)
                     /gene="miaB"
                     /locus_tag="KNP36_003602"
     CDS             complement(1755..3191)
                     /gene="miaB"
                     /locus_tag="KNP36_003602"
                     /EC_number="2.8.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (N6-isopentenyl
                     adenosine(37)-C2)-methylthiotransferase MiaB"
                     /protein_id="HBF0875428.1"
                     /translation="MSKRKQVTIPIEKIQEQDKYIEQIHRQNEEYFNRTGKRKLVFTQ
                     TFGCQMNEHDSEKLCSMLEEMGYQMSMMVEESDLIIYNTCAVRENAELKVYGNLGQLK
                     HLKGKNPDMKIAVCGCMMQQPHVVEELRKKYKHVDLIFGTHNLYKFPQLLTESINSDK
                     MLVDVWDVDGEVIEGLRSNRKFELKAFVNIMYGCNNFCTYCIVPYTRGRERSRTPEDI
                     INEIKELVANGTKEITLLGQNVDSYGKTLENPVSFSELLRKVNDIEGIERVRFMTSHP
                     KDISDEVIYAIRDCDKVCEFLHLPIQCGSSSLLKKMNRHYTKEYYLEIIEKAKKEVPG
                     IAFSTDLMIGFPGETEEDLLDTLDVVEKVRYDSAFTFIYSKRQGTPAAKMENQIPEDI
                     KHDRFNRVLEAVNRISAEINDGYKDRIVEVLVEGRSKNNENKFAGRTRQNKLVNFEGG
                     NDDLIGKLVMVKITEPRTFSLNGILVNN"
     gene            complement(3439..4875)
                     /locus_tag="KNP36_003603"
     CDS             complement(3439..4875)
                     /locus_tag="KNP36_003603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp28"
                     /protein_id="HBF0875429.1"
                     /translation="MKFYKRILTLTLSISFVFANIQLVDAISSVEKIQGKNKYEIAGK
                     IADKNAYKTAILINTSNSIADGLSASGLAGALNAPILLTEKNTIPTETSARLKNVSKV
                     YIIGGTYSISTSVENSLKSKKMKVVRIKGNDRIKTSYNVAKEINSIKKVNTVMLTNAY
                     KGEADAISIASVAARDKAPIILTNGQSIPFSTSGLKSYVIGGTASMSTTLVNNTKSTR
                     LGGSTRFETNKAIINKFYKDAREFYIAGAYELTNALVGSSLSKHGPMVLVNDGSNKSI
                     LKNAKKITSIGYIDSNIVQQCLNITNGIGDINTGVVKNVKPTTKTIKDGMYKVGKDIS
                     AGEYLITSNSGSYASYYEVTSDSTGNADSILSNDIFSGTRYITLKNGQYIKIEDSTMT
                     LAKYAKAQKAKNGKFGNGMYKIGLEIPAGEYIIMSNSSDAYYEVRNDSLGNAEGIVTN
                     DTFSGRRYITVEEGQYLILNDCYLIENE"
BASE COUNT         1706 a          758 c          541 g         2005 t
ORIGIN      
        1 tagatagtta ctatatctta taattagata aatcataatt atatattatt gttaaaactc
       61 aattatataa tttttaataa tattatttta ggaggtaaaa atgataaacg atattaaaaa
      121 taaattcaaa aattacaaac catatataaa tggatacaag aatatgaaga gagcatctgt
      181 tttaattcca atagtagaaa taaataacac acactatata ttatttgaag ttcgctcaaa
      241 aaatttgaag catcaaccta gcgaaatttc ttttccaggt ggtaaaatag aatcaggtga
      301 gactccatat gaagctgtta ttagagaaac ttgtgaggaa cttggaactt ttagtgacaa
      361 tatagaagta atatcaagtc ttgacctcct tataacacca gtaaagttta tcatacatcc
      421 atacttagga tatataaaaa atattaataa tttaaatata aacaaggatg aagttgacca
      481 tacttttttg gttcctataa aatatctttt agagaatcct ccaaatactt atagtaatac
      541 tgtaaaagtt tttccagatg aaaatctacc atatggttca attccaaacc aaaaagatta
      601 taaatttgaa agtggaagtt atcctattct gttttataaa tataaagatt atgtaatttg
      661 gggaatgaca gcaaaaatac tagaaaactt tttaaatttt ttatcagaat aacactcata
      721 ataaattatc aaaattttta cataagaaat ttataaaagt ttctaaattt aacaattcta
      781 aaatatcaat aactatattt tgtagcactt ttttatttta ttattgtttg aatatttgat
      841 ggttttcaat gcaatttcaa cataaatact atatattagt gtatactgtt gatgaattaa
      901 agtatgataa tctatttaat aaagtatgaa gtaaatgatt ttaatgtgcc tttatggtaa
      961 aattactaat aagtaataaa attaattaaa atatatggag gtccttataa tgtttgctgt
     1021 aggatttgtt gttataattg cacttgcctt tttcatttta agtgtactat tatttaatgg
     1081 aaaagccagt atgctactag caggttataa ctctatgagt aagaaagaaa aagcacgata
     1141 cgataaaaaa aaattatgta gaagttctag cattgttact tttattgtct ctataatgct
     1201 atttattatg gcgtttttgg gatatagaat agagagtggt caaatggacg aaaaaaaaat
     1261 ggttcccttt tctataatat ttataatagt catactttcc agtgtatttt ttaatatcct
     1321 ctactctaac aaaaaatgta aaaaataaat agttgtaagt tgagcagtta attataaaag
     1381 attgactgct ttttcatgta tattgactac tcttattaaa tattttaaca tttaaaaatc
     1441 tatgtaaaaa taatgaatat agtacaaact tctaataatg attttacctt tgtggttaca
     1501 gtccactata tataatttaa tatgataaca gggaattatt aatgacaact aagtaaactt
     1561 ttataaaata taataaaaca aaaatagatg tacaatgaaa ttatatctta tatcaaattt
     1621 atttttatta atagcaaaaa cttacattag cataacatat gacaaattcg cttaaaataa
     1681 aaatttttaa tataatttgt tctatagtac atctattttg attagtttac ataattttat
     1741 tattttgtac aatattaatt atttactaat atcccattta atgaaaaagt tctaggttca
     1801 gtaattttga ccataactaa tttaccaatt aaatcatcat ttccaccttc gaaatttacg
     1861 agtttatttt gtctagttct accagcaaac ttattttcat tatttttact tcttccttca
     1921 actagaactt caactattct atctttatat ccatcattta tttctgcaga aatcctattt
     1981 acagcttcta acaccctatt aaatctatca tgctttatat cttctggtat ttgattttcc
     2041 attttagcag caggagttcc ctgtctttta gaataaataa atgtaaaagc tgaatcatat
     2101 ctaacttttt caaccacatc taaagtgtcc aataaatctt cttctgtttc tcctgggaaa
     2161 ccaatcatta agtctgtaga aaaagcaata cctggaactt cctttttagc tttttctatt
     2221 atttctaaat aatattcctt tgtataatgt ctattcattt ttttcaaaag gctactgctt
     2281 ccgcattgta ttggtagatg taaaaactca cacaccttat cacaatctct aattgcgtat
     2341 attacttcat cagatatatc ttttggatga gatgtcataa atcgaaccct ttcaattcct
     2401 tctatatcat tcacttttct taaaagttct gagaatgaaa ctggattttc aagtgtctta
     2461 ccataagaat ctacattttg tccaagtaaa gtgatttctt tcgttccatt tgcaacaagc
     2521 tcttttatct cgttaattat atcttcagga gttctacttc tttctcttcc tcttgtgtat
     2581 gggactatac aatatgtgca gaaattattg catccataca ttatatttac aaatgctttt
     2641 aattcaaatt ttctattact tctaagacct tctattactt ctccatccac atcccataca
     2701 tccactaaca ttttgtcaga atttattgat tctgtaagta attgcggaaa tttatataga
     2761 ttatgtgttc caaatataag gtctacatgt ttatattttt ttcttaattc ctctacaaca
     2821 tgtggttgtt gcatcataca tccacataca gctattttca tatctggatt ttttcctttt
     2881 agatgtttta attgtcctaa gttaccatat acttttagct ctgcattttc tctaactgca
     2941 caggtgttat atattattaa atcactttct tcaaccatca ttgacatttg gtatcccatc
     3001 tcttctaaca ttgaacataa tttttctgaa tcatgttcat tcatttgaca cccaaaggtt
     3061 tgagtaaaca cgagttttct ctttccagtt ctgttgaagt attcttcatt ttgtctgtgt
     3121 atttgttcta tatatttatc ttgttcttgt attttctcta taggtattgt tacttgtttt
     3181 cttttgctca cgtctattcc tcctagttaa tttcttatat tacacataac cttaattata
     3241 tcaaataaga aaaatctttt aaagatatta ttatttttct agttgtgttt taatagtaaa
     3301 tctaatgatt tatatatact atatttctaa aatataaaat catataatta ttataataat
     3361 aaaaagatgt tttaaattaa aacttaaaac acctttcctt aaataaaata tatgatttac
     3421 tattaaatac aattacatct attcattttc aattaaataa caatcattta atattaaata
     3481 ttgaccttcc tcaaccgtta tatatcttct tcctgaaaaa gtatcattag taactattcc
     3541 ctctgcatta cctaagctat catttctaac ttcataatat gcatcagaag aatttgacat
     3601 tataatatat tctccagcag gaatttctaa tccaatttta tacataccat ttccaaactt
     3661 accattcttg gccttctggg ctttagcata ctttgctaat gtcattgttg aatcctcaat
     3721 tttaatatat tgaccattct ttaaggtgat atatctagtc ccactaaaaa tatcatttga
     3781 aagtatacta tcagcattac ctgtactatc acttgtaact tcataataag aagcataact
     3841 tcctgagttt gaagttatta agtattcacc tgctgagata tcttttccaa ccttatacat
     3901 tccatctttt atagtctttg tagtaggttt aacatttttt acaaccccag tattaatatc
     3961 tccaattcca tttgttatat ttaaacactg ttgtactata tttgaatcta tatatcctat
     4021 agaagttatc ttcttagcat tttttaaaat gcttttattg ctaccatcat taactaaaac
     4081 cattggacca tgttttgata aagaagatcc tacaagtgca tttgttaatt cataagctcc
     4141 agctatataa aactctctag catccttata aaacttattt attattgctt tattagtttc
     4201 aaaacgagta ctccccccta gtctagtaga tttagtattg tttactaaag tggtactcat
     4261 tgaagctgtt cctcctatta cataagactt taaaccacta gttgaaaaag gtatactttg
     4321 tccattagta agaattattg gtgctttatc tcttgctgct acagatgcaa tacttatagc
     4381 atctgcttct cctttatatg cattggttag cataacagta ttgacttttt ttattgaatt
     4441 tatttctttt gcaacattat aacttgtttt tattctgtca tttcccttaa ttcttacaac
     4501 tttcattttc ttagatttta atgaattttc gacagatgta ctaatagaat atgttcctcc
     4561 aattatataa acttttgata cattttttaa tcttgcagat gtctcagttg gtatagtatt
     4621 tttttcagtt aatagtatag gggcatttaa agctcctgct agtccacttg cacttaatcc
     4681 atctgcaata gagttactag tattaattaa tatagcagtt ttatatgcat ttttatctgc
     4741 tattttacct gcgatttcat acttattttt tccttgtatt ttttctacag atgatattgc
     4801 atctactaat tgaatatttg caaatacaaa agaaatactt aaagtcaatg ttaatattct
     4861 tttatagaat ttcataataa aattgtcccc ctcataataa atttttaata tataaataca
     4921 tattcttaaa ttagttatgt acttaacaaa cttatgtaaa attgcaaatt atattaagca
     4981 tattacaaat aaatattaat acaattattc
//
LOCUS       DAEHWM010000163         4948 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.166, whole genome shotgun sequence.
ACCESSION   DAEHWM010000163 DAEHWM010000000
VERSION     DAEHWM010000163.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4948)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4948)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4948
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.166"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1643
                     /locus_tag="KNP36_003604"
     CDS             <1..1643
                     /locus_tag="KNP36_003604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875430.1"
                     /translation="TIIIINYHLIQRWTHISNRGISFNDYLSLSVYTCMTISILTMLN
                     VIFYMRKSYDTVKILCRNNFDYFLGISVAVTRNNFIFCCIPIIYAIAYSSLIRTLSIV
                     TIKSTIFILIFEWFLPLTILSIVISFISVIINNLILKITLSSVFLYLTSTNMLDRVID
                     IKEPFFKALFKSLNIFEDQSYAYYSDFVGKVNNSAYVIDKIIPTLFAITLIIVAYLIL
                     NDIRKKQIKSLIVIVVYSILFIGLNYISIDMSTYRDEERSYGEYLKKSNISDIKIKSH
                     DMKIDFKSKSNIKDRIVLLNTSNEELTNINMILDEIFDIKYIKINSENIKFNKKKDLI
                     EVNLKESLEPNDEVTLDIEYEGYINVLTSWNQNKYIATKDDIMLPPGSLAWYPKVNQS
                     SCMAYKINLSSKNNVYSNLPLLNKTSNFLKKDYIFEGKSNDIAIYAGEFKEEVKDDIK
                     IIYPSDSNVNMDIEEKIKFLIETRNEILGDSKASVDAKKYVDEVDNVMESIKRKKINM
                     ILVADLPSNEFLYEDSKGEKISITIYHWLSGNILIIDK"
     gene            1658..2530
                     /locus_tag="KNP36_003605"
     CDS             1658..2530
                     /locus_tag="KNP36_003605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HBF0875431.1"
                     /translation="MINKLEIRNLNFNYKNKKALDNINLTLIDGVVALLGPNGAGKST
                     LMRLLVTLYETSIGEIELNNIKYSKNNEKIKANVGYVPQDFDMYNNINGQEYLEFVAK
                     MRGVSKNDLKKHIQKVVSKVNLDKFINKKIGTYSGGVKRRLGIAQALIGDSKLIVMDE
                     PTVGLDPEQRNEFRRLLPEISKNSIVLISTHIVEDIQFNCDKLIILNQGKILYDGTIN
                     KFIDMVEVYSVVVSNDEFEYLERNIDIIDYRRVKDGVQVKYIGKNTEKLKDSLRIDTT
                     LQDAYINFLHKELK"
     gene            2531..3319
                     /locus_tag="KNP36_003606"
     CDS             2531..3319
                     /locus_tag="KNP36_003606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875432.1"
                     /translation="MCILELIKFELKKIELKHVLIFVIISILCIFITGILDYNELIFY
                     NDVPIMDTYSIAGWLGIIKISDVFIPIMSAITIIYVFSKDYSGNINEILTLYNKKKYN
                     QFIVFRWCVILAIYTVLLLISITIVYTFTSVKGFNIDKIDFVYSVKPIDVFLKTFPTL
                     LWYTTFPLMILTLTKNRFTTIAILITYTFADIFFILHMYPFVSMINVNGFYIQKMFYM
                     PNNIDVRFNELKNYFFINRGSLVVISIIIVSYIARKSTVLKKSK"
     gene            complement(3415..4248)
                     /locus_tag="KNP36_003607"
     CDS             complement(3415..4248)
                     /locus_tag="KNP36_003607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prenyltransferase"
                     /protein_id="HBF0875433.1"
                     /translation="MNVENQSLSDIEIILSHRYDNGADYWTTPDKRLIKGSPFSTLDS
                     VLYLLELGVNPDDTLLKECADLIFSTWREDGRFKLYPNGGIYPCHTANAANVLCHMGY
                     ASDIRMQKTFQHFLDTQYTDGGWRCNKFSFGRGPETEYSNPLPTLNILNAFRFSNYLN
                     KESKLDKAVDFLLDHWTIKKPIGPCHYGIGTLFMQVEYPFRNYNLFLYVYVLSFYNCA
                     KKDNRFLEALKILESKMIGNKIVVERVVPKLSKLSFCKKGESSEIATTHYYEILKNLE
                     K"
     gene            complement(4316..4945)
                     /locus_tag="KNP36_003608"
     CDS             complement(4316..4945)
                     /locus_tag="KNP36_003608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3786 domain-containing protein"
                     /protein_id="HBF0875434.1"
                     /translation="MDEKITKNNYNVPFDYVRKKLKELDPHTISNLSNIPFNNDLNRF
                     TLNFFDRQYIIDYPSGEVWNSNGSLCNNFELKILIVRYLINAKGIPRTNKYVTFKEIP
                     GGNVYYPNFLNRTLYRLSEVFTSQIDKYKLVMEKIGAEKVNMGDLAYRFTYMGNTSMV
                     FILWFGDDEFPPNSNILFDSNIVYYFNAEDLAVVPDTAINAILNKINQL"
BASE COUNT         1921 a          535 c          700 g         1792 t
ORIGIN      
        1 taacaattat tattataaat taccatctca tacaacgatg gacacatata tccaatagag
       61 gaatttcatt taatgattac ttatccttga gtgtatatac ttgtatgaca attagtattt
      121 taaccatgtt aaatgtaatt ttttatatga gaaaaagtta tgatactgta aaaatattat
      181 gtagaaataa ttttgattat tttttaggta tttctgttgc tgtaactaga aacaacttta
      241 tattttgttg cataccaatt atatatgcta tagcatactc aagtttaata agaacattgt
      301 caattgtaac gattaaatca actatattta tattgatatt tgaatggttt ttaccactta
      361 ctattttatc tatagtgata tcatttattt cagttattat aaataattta atactaaaga
      421 ttaccttatc atcagtattt ttatatttaa catcaactaa tatgttggat agagttattg
      481 atattaaaga accatttttt aaagcattat ttaaatcact taacatattt gaagatcaat
      541 catatgctta ctattctgat tttgtaggga aagttaataa ttcagcatat gttatagata
      601 agattatacc tacactattt gcaattactt taataatagt agcatatctg atattaaatg
      661 atattagaaa gaaacagatt aaatcattaa tagttatagt agtgtacagt attttattta
      721 ttggattaaa ttatatatca atagatatgt caacatatag agatgaggag cgtagttatg
      781 gagagtattt aaagaaatct aatattagtg atattaaaat aaaatcgcat gatatgaaga
      841 ttgactttaa aagcaagtca aatataaaag atagaattgt tttattaaac acatcaaatg
      901 aagagttaac aaatattaat atgattttag atgaaatatt tgatataaaa tatataaaaa
      961 taaattcgga aaatataaaa tttaacaaaa aaaaggattt aattgaagtt aatttaaagg
     1021 aaagtttaga gcctaatgac gaggtgacat tagatataga gtatgaaggc tatattaatg
     1081 tgttgacatc ttggaatcaa aataaatata tagctactaa agatgatatt atgcttccac
     1141 caggttcttt agcgtggtac ccaaaagtaa atcaatcaag ttgtatggct tataaaataa
     1201 atttaagttc taaaaataat gtctattcaa atttaccttt actgaataag actagtaatt
     1261 ttttaaaaaa agattatata tttgaaggaa agtcaaatga tattgcaata tatgcaggtg
     1321 agtttaaaga agaggtaaaa gatgatataa aaataatcta tccatcagat agtaatgtaa
     1381 atatggatat agaggaaaaa attaaatttt taattgaaac aagaaatgaa atattaggtg
     1441 atagcaaagc atctgtagat gctaaaaaat atgtagatga agtagataat gttatggaat
     1501 caataaaaag aaaaaaaatt aatatgatat tagttgctga cttacctagc aatgaatttt
     1561 tatatgaaga ctcaaaggga gagaaaatta gcataactat ttatcattgg ctttcaggaa
     1621 atatccttat aatagataaa taataaagga ggttaatatg ataaacaagt tagaaataag
     1681 aaatctaaat tttaattaca aaaataaaaa agctttggat aatataaatt taaccctaat
     1741 agatggagta gttgcattat taggtcctaa tggtgctgga aaatcaacat taatgaggtt
     1801 attagtgact ctttatgaaa cttcaattgg agagatagaa ttaaataata taaagtatag
     1861 caaaaacaat gagaaaatca aggcaaatgt aggatatgta cctcaagatt ttgatatgta
     1921 taataatata aatgggcaag aatacttaga atttgtagct aaaatgagag gtgtatctaa
     1981 gaatgattta aagaaacata tacaaaaagt agtatcaaaa gttaatctgg acaagtttat
     2041 aaataaaaaa ataggtacat actcaggtgg tgtaaagaga cgactaggta tagcacaggc
     2101 tttaataggt gattctaagt taatagttat ggacgaacct acagttggtc ttgatccaga
     2161 gcaaaggaat gaatttagaa gattgttacc agaaataagt aaaaattcta tagtattaat
     2221 ttcaactcac atagtagaag acatacaatt taactgtgac aaattaatta tattaaatca
     2281 aggcaaaata ttatatgatg gtacaattaa taagtttatt gatatggttg aggtgtattc
     2341 ggtagtagtt tctaatgatg aatttgaata tttagaacgt aatattgata ttattgatta
     2401 taggagagtt aaagatggtg tgcaagtaaa gtatataggt aaaaatacag agaaacttaa
     2461 agatagctta aggatagata caactttaca agatgcttat ataaactttt tacataagga
     2521 gttaaaataa atgtgtatat tggagttaat aaaatttgag cttaaaaaaa tagagcttaa
     2581 acatgtgtta atatttgtaa ttatttctat cttatgcata tttattacag gcatattaga
     2641 ttataatgag ttaatatttt ataatgatgt acctataatg gatacatatt ctatagcagg
     2701 atggttagga attataaaga tatcagatgt ttttatacca ataatgtcag caatcacaat
     2761 aatttatgtg ttttcaaaag attattcggg taatataaat gagatactta ctttatataa
     2821 taaaaaaaaa tataatcaat ttatagtatt tagatggtgt gttatattag ctatatatac
     2881 tgtattatta ttaatttcaa ttacaatagt atatacattt acgtcagtga aaggttttaa
     2941 catagacaaa atagattttg tttatagtgt aaagccaata gatgtgtttt taaagacatt
     3001 tcctacatta ttatggtata caacatttcc actaatgata ttaacattaa caaaaaatag
     3061 atttacaaca atagcaatat taattacata tacatttgct gatatatttt ttattttaca
     3121 tatgtaccca tttgttagta tgattaatgt aaatggattt tatattcaaa agatgtttta
     3181 tatgcctaac aatatagatg ttagatttaa tgaattaaag aattatttct ttataaatag
     3241 aggttctcta gtagttattt ctataataat agtttcttat atagcaagaa aatcaacggt
     3301 tttaaaaaag agtaaatagt ttaatatatt ttttataatg ttatatttat atagaatagt
     3361 gactttaaaa aatttaaagc cactattttt taatatgttt tatctatata actattattt
     3421 ttctaggttt tttaatattt cgtaatagtg tgttgtggct atttcacttg actcgccttt
     3481 tttacaaaaa gataatttag atagttttgg aactacacgt tcaacgacaa ttttattacc
     3541 tatcatttta gattcaagta tcttcaatgc ttctaaaaat ctattatcct tttttgcaca
     3601 attataaaat gataaaacgt agacataaag gaataggtta taattacgga aaggatattc
     3661 aacttgcata aataaggttc caattccata gtgacaaggg ccgattggtt ttttaatagt
     3721 ccaatggtca agtagaaaat ctacagcttt gtcaagtttt gattctttat ttagataatt
     3781 actaaaacgg aatgcattta atatattaag agttggtagt ggatttgagt attcagtttc
     3841 tggacctcga ccaaaactaa atttattgca acgccaccca ccatcagtat actgtgtatc
     3901 taaaaaatgt tgaaacgttt tttgcattct aatgtcagat gcatatccca tatgacagag
     3961 tacgttagca gcatttgcag tatgacaagg gtaaatacct ccatttggat atagtttgaa
     4021 acgtccatct tctcgccatg tgctaaatat caagtcagca cattctttaa gtaaagtatc
     4081 atcagggttc acacctaatt ctaatagata aagtacacta tcaagagtag agaaaggaga
     4141 accttttatt aaacgcttat caggtgtagt ccaatagtct gcaccattat catacctgtg
     4201 tgataatatt atttcaatat ctgataaaga ttgattttct acattcattt tttactccat
     4261 ttcatattat attctattaa atctatcaaa aactttatta taatattatt tatatttata
     4321 attgatttat tttatttaaa attgcattta tagctgtatc aggaacaact gctaaatctt
     4381 ctgcattgaa gtaataaact atattagaat caaataatat atttgaattt ggaggaaatt
     4441 catcatctcc aaaccaaagt ataaatacca tagatgtatt acccatatat gtaaacctat
     4501 aagctaaatc tcccatgttt actttttcag ctccaatttt ctccataact aacttatatt
     4561 tgtctatttg agatgtaaaa acttctgaaa gcctatatag agtcctgttt aaaaaatttg
     4621 gataataaac attgcctcct ggtatttctt taaaagttac atatttatta gttctaggaa
     4681 tacctttagc attgattaaa tatctaacta tcaagatttt aagctcaaag ttattgcaaa
     4741 ggctaccatt actattccaa acttctccac ttggatagtc tataatatat tgtctatcaa
     4801 aaaaattgag tgtgaatcta tttaaatcat tattgaaagg tatattactt aaattactaa
     4861 ttgtatgagg gtctaattct ttgagttttt ttcgaacata gtcaaatgga acattataat
     4921 tattttttgt tatcttttca tccataat
//
LOCUS       DAEHWM010000164         4932 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.167, whole genome shotgun sequence.
ACCESSION   DAEHWM010000164 DAEHWM010000000
VERSION     DAEHWM010000164.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4932)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4932)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4932
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.167"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(548..1189)
                     /locus_tag="KNP36_003609"
     CDS             complement(548..1189)
                     /locus_tag="KNP36_003609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase"
                     /protein_id="HBF0875435.1"
                     /translation="MNNNFQDNQTINLIQSRRSIRKFTTEQISDEQVNTLLHCAFAAP
                     SGCNKQPWHITVVQDQKLLKEISDDTLSRIHEVSNVEINKNFKLFYGAPTVLFISYDE
                     SSSWAPYDIGILTGNITTAAQALGLGSCIIGMVRGLFTPVEQGDIEGLVSVLDKEDVK
                     ESESIKMKFDTNKKYRELLDIPEGYSVPFGIAVGIPDGNLPNAREVVYKVSRV"
     gene            complement(1432..2235)
                     /locus_tag="KNP36_003610"
     CDS             complement(1432..2235)
                     /locus_tag="KNP36_003610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin-type N-terminal cleavage/methylation
                     domain-containing protein"
                     /protein_id="HBF0875436.1"
                     /translation="MNKKGFTLIELLVVISIIGILVIVAVPALFRNIEKSKAVTCLSN
                     RENIKTQIVIAMAEESSKGKNEVMKEVLENKDGKYFETEPKCKSGGIYSATFDDGYDG
                     ITGIESIAKVYVTCTKHPDGVEMARDIHQSMKDLIASFAQDPSIIPGASKGNDDFRKY
                     LLDNKYKNGWPTIPDEFKAKYGLSKDTLYIQPYAYNPTKSDATVVVFANNKTGGNWYT
                     SLVYDYDEGRWYKGKNGISVAGRSWDVDTDSVKSVKTEIHSKEGWGPLN"
     gene            complement(2391..3566)
                     /gene="thiI"
                     /locus_tag="KNP36_003611"
     CDS             complement(2391..3566)
                     /gene="thiI"
                     /locus_tag="KNP36_003611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HBF0875437.1"
                     /translation="MVYNILIVKYGEIGVKGKNRYIFENRLIRNIRNMLKPIGRFNVY
                     KEYGRIYVDLEDYDYEEVIEEVRKVFGIVGVCPGVRAKKDYDTLKEIALKMLEEKIEA
                     GYKTFKVESRRGDKSFGLTSQEMSMDIGGYLLSKVGDRINVDVRNPEVKIKCEYREFH
                     TMVYSDTIPGYGGLPLGTNGRAMSLLSGGIDSPVATWMVAKRGMEVEAVHFHSYPFTS
                     ERSQEKVKDLAKILAKYCGRVRLHKVNILEIQKAIGENCNEEESTILSRRFMMRIAQR
                     LSEKRHCDALITGESIGQVASQTIQGLTCTNAVVDLPVFRPLIAMDKSDIVDIAKKIG
                     TFETSIVPEEDCCSVFSPRKPVTKPRLEKIEKSETALDIEKLVQDAIDKIEVEDIEF"
     gene            complement(3612..4763)
                     /locus_tag="KNP36_003612"
     CDS             complement(3612..4763)
                     /locus_tag="KNP36_003612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HBF0875438.1"
                     /translation="MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEK
                     AIKEVRQDIAKSLGAKEKEIYFTSGGTECNNTIIRGITSLNKKRKNHIISTNIEHPSV
                     LNTLKDLEEDGFEVTYLEVGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGE
                     VGKYLKGLKEKIYFHVDAIQSYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKEN
                     NRLKPMLTGGGQEIGIRSGTENVPGIYGLGEAVRILNKDLDAVISKVDNLKNILKNEI
                     IDNIEDIKINSPEDGVCHILNVSFRGTKGEVLLHYLEQKGIYVSTGSACSSKKKGSYV
                     LNAIGLTNEEINGTIRFSLSDMNTEEEMLEAVKVLKESICDLRSIMKRK"
BASE COUNT         1534 a          930 c          473 g         1995 t
ORIGIN      
        1 tattgaaaat ttagatattt ttctaaaaat tatctatgtt aatagttaaa tttatgaaca
       61 ttttttgttt ttatgttagg atatttctta gaaatgaaat acttcttaat ttgatttgat
      121 atgtatattt ttatagctat tttattataa aaaaaaagaa cccttttata actaagggtt
      181 actttttttc tctatttttt cttattatat cactattttt tccctatttc aatattttga
      241 cattttttcc attatactga aaagatatct taaattttta acttggataa attttaaagc
      301 atatacttaa aattaacata cttgttttct attttattac acttaatcct tatttttatc
      361 attctacaaa acaaaaataa aaaagaataa gataataaat aaaatactta tcaccttatt
      421 ctttatttaa ttattttaca acgaaaaatc taaactactt tttaaatagc ttcctcttcc
      481 atcaatttat ttgtatatta ctgatttaat tcttcaagta actgattggt tcttgcaata
      541 ctttatccta aactctggaa actttgtaaa ctacctctct agcatttggt aaatttccat
      601 ctggaatacc tacagcaata ccaaatggta cagaataccc ttctggtata tcaagtagtt
      661 ctctgtattt tttatttgta tcaaacttca tctttattga ctctgattct tttacatctt
      721 ctttatccaa tacactcaca agaccttcaa tatccccttg ttcaacaggt gtaaataaac
      781 ctctaaccat tcctattata caacttccaa gccctagtgc ttgtgcagct gttgttatat
      841 tccctgtaag tattcctata tcatatggag cccatgaact actttcatca taagaaataa
      901 ataaaacggt tggagcacca taaaataact taaagttttt atttatctca acattactca
      961 cctcatgaat cctagataaa gtatcatcac taatctcttt taaaagtttc tggtcttgca
     1021 caacagttat gtgccaaggc tgtttattac atcctgaagg tgctgcaaat gcacagtgta
     1081 ataatgtgtt tacttgctca tcactaattt gttctgtcgt aaattttcgt atacttctac
     1141 gactttgtat taaatttatt gtttggttgt cttgaaaatt attattcata tctattcccc
     1201 tttttatgta tttcttagta caaatactaa atcttcagaa aattaatctt ataattaaat
     1261 ttctttacaa tattattata attattttta gcttgtatgt gaagacttaa aaatataaac
     1321 acttttaata tatctcaatt atatatataa atgaaaatct ggtattcgtc atctatagaa
     1381 actgctcttt tctatagttt aatcaatacc agattaataa aacatgatat attaatttaa
     1441 aggaccccat ccctctttag aatgaatctc tgtttttaca gacttaacac tatctgtgtc
     1501 aacatcccat gacctacctg caacagaaat accattttta cctttatacc atctaccttc
     1561 atcataatcg taaactaggg aagtatacca attaccccca gtcttattat ttgcaaatac
     1621 aactacagta gcatcagatt tagtaggatt atatgcatat ggttgtatat atagtgtatc
     1681 cttacttaat ccatattttg ccttaaattc atctggaatt gtaggccacc catttttata
     1741 tttattgtct aataaatatt ttctaaaatc atcattaccc tttgaggctc ctggtattat
     1801 agaagggtct tgtgcaaatg atgcaatcaa atctttcata ctttgatgta tatccctagc
     1861 catttcaaca ccatctggat gttttgtaca agtaacatac acttttgcaa tgctttctat
     1921 tccagttatt ccatcataac catcatcaaa cgttgctgaa tatattccac ctgacttaca
     1981 ctttggttct gtttcaaagt acttaccatc tttgttttct aatacctctt tcatgacttc
     2041 attcttgcct ttacttgatt cctcagccat tgcaataaca atttgagtct ttatattttc
     2101 tctattagaa agacatgtaa ctgctttact tttttctata tttctaaaca atgctggaac
     2161 agctactata actaaaatgc ctattataga tataactact aacaattcaa ttagtgtaaa
     2221 acccttttta ttcataataa tcattcccat taaataaaat tatagtactt atttttaaat
     2281 actacatatt aataaattgt ctacataaat cctttcaaca gaactactaa tatacttaca
     2341 gaactactaa tatactcaat attcaattta gtaattaaat aacttgtatg ctaaaactca
     2401 atatcctcta cctctatttt gtcaatagca tcctgtacta atttttcaat gtcaagtgct
     2461 gtttcagatt tttctatttt ctctaatcta ggtttagtga cgggctttct aggagaaaat
     2521 acactacaac aatcttcttc aggcactata gatgtttcaa aagtccctat ttttttggct
     2581 atatcaacta tatctgattt atccattgct ataagtggtc taaacactgg taagtctaca
     2641 acggcattag tacaagtaag tccttgtata gtttgagatg caacctgccc aatactttca
     2701 cctgtaatta aagcatcaca atgtcttttt tcagaaagtc tctgcgctat cctcatcata
     2761 aatcttcttg aaagaatagt agattcttct tcattacaat tctcgccaat tgctttttgt
     2821 atttctaaga tattaacttt atgaagcctt actctaccac agtattttgc cagtatttta
     2881 gctaaatcct taactttttc ctgtgacctt tcacttgtaa atggataact atgaaagtga
     2941 actgcctcta cttccatacc tctttttgca accatccatg tagctactgg gctatctata
     3001 cctcctgata aaagagacat agctctacca ttcgttccaa gtggcaatcc accatatcca
     3061 ggtatagtat cactatagac catagtatga aattctctgt attcgcactt tattttaact
     3121 tctggatttc ttacatcaac attaatccta tctcctacct ttgataataa gtatccacct
     3181 atatccatac tcatttcttg agaagtcaat ccgaaagact tatctcctct tcttgactct
     3241 accttaaaag ttttatatcc agcctctatt ttttcttcta acatttttaa agctatttct
     3301 tttaatgtat cataatcttt tttagctctt actccagggc acacacccac tatcccaaat
     3361 acttttctaa cttcttcaat tacttcttca taatcatagt cttctaaatc aacatatatt
     3421 cttccatact ctttatatac attaaatctt ccaattggtt ttaacatatt tcttatattt
     3481 cttataagcc tattctcaaa tatatatcta ttctttcctt ttactccaat ttctccatac
     3541 tttactatta atatattata caccatttca cctcttaaac taatttatta tcactattta
     3601 tacagtattc tttattttct tttcattatt gaccttaagt cacaaattga ttctttcaaa
     3661 actttcacag cttctaacat ttcttcttct gtattcatat cagataaact aaatcttatt
     3721 gttccattta tttcttcatt tgtaagacct atagcattta atacgtaact acctttcttt
     3781 ttagaagaac atgcagagcc agttgataca taaatacctt tttgctctaa gtaatgaagt
     3841 aaaacttctc cttttgtccc tctaaatgat acatttaata tatgacatac tccgtcttct
     3901 ggagaattga tttttatatc ttctatatta tcaattattt cattttttaa tatatttttt
     3961 aagttatcta ctttcgaaat aacagcatct aaatctttgt ttagtattct aacagcttct
     4021 ccaagaccat atattccagg tacattttct gttcccgacc taattccaat ttcctgacca
     4081 ccacctgtta acataggctt aaggcgatta ttttctttta tatacataaa tccaattccc
     4141 tttggaccat gaaatttatg tgcacttaca ctcataaaat ctatattgta tttagatggt
     4201 ctaaagttaa tttttccata tgactgaata gcatcaacat ggaaataaat tttttctttt
     4261 aaacccttca aatactttcc aacttcacct attggctgta tagttcctat ttcattgtta
     4321 acatgcatca tgcttactaa gcatgtagtt gactttatcg cattttttaa atcctctata
     4381 tttattttcc catcttttcc gacctctaaa taagttactt caaaaccatc ttcttctaaa
     4441 tcttttaatg tatttaaaac agaaggatgt tctatgttag tagatattat gtgatttttt
     4501 ctttttttat ttaaactagt aatacctctt attatagtat tattacactc tgtaccacct
     4561 gatgtaaaat aaatctcctt ttctttcgct cctagagatt tagctatatc ttgtcttact
     4621 tcttttatag ctttttcaac ttctacacct tttctatgga cagaagaagg atttccatat
     4681 tccgtattaa gtgcataaac cattttatct ataacttctt gataaggttt tgtagttgcg
     4741 ctattgtcta agtatatttc caacttaatt acacctacct ttatttaaaa tcttcaactc
     4801 taactattat accactaatt atagtatttt ttttgttaat ctttattaaa aagacaatct
     4861 taaattataa aatattattt catgaaaagc tagttttttc actttattac aaatttttat
     4921 agtaaaatat aa
//
LOCUS       DAEHWM010000165         4557 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.168, whole genome shotgun sequence.
ACCESSION   DAEHWM010000165 DAEHWM010000000
VERSION     DAEHWM010000165.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4557)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4557)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4557
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.168"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            203..1678
                     /locus_tag="KNP36_003613"
     CDS             203..1678
                     /locus_tag="KNP36_003613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="HBF0875439.1"
                     /translation="MDSEFANAVELSYECAPLLESLKEYSEKDIACFDVPGHVKNRGV
                     AILNKYLGESLMKMDINSSPTMDNVSAPNGIIKNAQDLLAQAYMADEAFFITNGTTQA
                     IHAMILSVIKPGEKVLLPRNIHKSVINALILCGGIPIFIQPEFDEKLGISLNITLEKV
                     RTEIEKDCNIKALFFLNPTYYGVCADLESIIELCHKNNVLVLVDEAHGAHFPFHLDLP
                     PSAISLGADMVAVSIHKTGGALTQSSALLLNRDNVSFEKVLQSINMLQSTSASYLLMA
                     SIDGARVNLVENGEKQLSKALNLSRYAKSKLNKIDGIKVLSTEILKQKGVKFIDETKL
                     CINVKELNLTGFEVYDLLYKNFSIQVELGDSYNILALVSIGTNKSDIDRLVKALSIIA
                     KIYRKESTLNEFNMVQINPIIKLNPREAFYAPKESVEINSCIDRICGESIMAYPPGIP
                     IIAPGELITEEIMEYIIFLKNSNAYLTDVQDKNLDRILVIK"
     gene            1765..2178
                     /gene="speD"
                     /locus_tag="KNP36_003614"
     CDS             1765..2178
                     /gene="speD"
                     /locus_tag="KNP36_003614"
                     /EC_number="4.1.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenosylmethionine decarboxylase"
                     /protein_id="HBF0875440.1"
                     /translation="MKFETLGRHILVEYYNCDENVLKDPRLIENFMNDSALNAKATIV
                     DSVFHHFNPWGVSGAVIIAESHLTIHTWPEYGYAAADFFTCGDIDPWKSFELLEQLLK
                     SERSESTEIPRGLTTKIKKYSKKDLGKITHKPEAV"
     gene            2208..3059
                     /gene="speE"
                     /locus_tag="KNP36_003615"
     CDS             2208..3059
                     /gene="speE"
                     /locus_tag="KNP36_003615"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HBF0875441.1"
                     /translation="MELWYTEEWTENVRFSIKVNKHLFEGKSQFQRIDVFDSDEFGKF
                     LTIDGLMMVTYKDEFIYHEMITHVPMATNLNIKKVLVIGGGDGGTVRELSRYPQIEKI
                     DMVEIDKMVVDVSKEYMDICSCKLDDKRVSLYFEDGVNFVKCAHDKSYDLIIVDSTDP
                     IGPGEGLFSTDFYKDCYRILTDDGILVNQSESPYFDFNAKEMKRANKKLKQIFPISEV
                     YQAHIPTYPSGHWLFGFASKKLNPVKNQDRNGWEKLSLKTKYYNSDIHLGSFMLPQYV
                     KEMLDEE"
     gene            3049..3927
                     /gene="speB"
                     /locus_tag="KNP36_003616"
     CDS             3049..3927
                     /gene="speB"
                     /locus_tag="KNP36_003616"
                     /EC_number="3.5.3.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatinase"
                     /protein_id="HBF0875442.1"
                     /translation="MKNNFYHMNTFMSMDKNYEESNLIVFGVGFDGTTSNRPGARFAS
                     SSMRKEFYGLETYSPFLDLDLEDYNICDYGDLEISVGSTEQVLKEIYQETYKIVRDSK
                     VPFMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNNSKNSHATVIKRIWDI
                     VGDNKIFQFGIRSGTKEEFKFATEEKHTYMEIGGIDTFENIVNMLNGKNIYLTIDLDV
                     LDASVFPGTGTPEPGGVNYREFQEIFKIIKNSNINIVGCDIVELSPDYDTTGVSTVIA
                     CKILRELCLIISDKIK"
     gene            complement(4107..4307)
                     /locus_tag="KNP36_003617"
     CDS             complement(4107..4307)
                     /locus_tag="KNP36_003617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000809131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold-shock protein"
                     /protein_id="HBF0875443.1"
                     /translation="MKNGIVKWFNNEKGFGFISVEGEDDVFVHFSAIQNDGYKTLEEG
                     EKVSFDITQGNRGPQAENVNRI"
BASE COUNT         1822 a          502 c          773 g         1460 t
ORIGIN      
        1 caacaaaaaa ataaaaagtt tataaatatt gatatagcta atgtatatgt ttttgagtaa
       61 cttcaaaaaa acacttgtaa aaatgctgag atgttaatat aataaatatc atgagtttaa
      121 taaaagtaaa aataaaaaat agaaataata aataataaat attaaaaata tttgaatata
      181 gagaggagat gaatttgaaa tcatggatag cgagtttgca aatgcagttg aattaagcta
      241 tgagtgtgct ccattattag agtcgttaaa ggaatactca gagaaagata tagcttgttt
      301 tgatgtgcct ggacatgtaa aaaatagagg tgtagctata ttaaataaat atctaggtga
      361 aagtctcatg aaaatggata taaattcatc accaactatg gataatgtat ctgcgccaaa
      421 tgggattata aaaaatgcac aagatttgct agcacaagca tatatggctg atgaggcatt
      481 ctttataacg aatggcacaa ctcaagcaat acatgcaatg attttgagtg ttataaaacc
      541 aggtgaaaaa gtattacttc caagaaatat acataaatca gtaataaatg cgttaatact
      601 ttgtggagga ataccaatat ttatacaacc agaatttgat gaaaaactag gtataagttt
      661 aaatattact cttgaaaaag ttagaacaga gatagaaaaa gattgtaata taaaagcatt
      721 atttttcctt aatccaactt actatggagt ttgtgcagac cttgagagta ttatagaact
      781 atgccataaa aataatgttt tagtgttagt tgatgaagct catggtgcac attttccatt
      841 tcatttagat ttacctcctt ctgcaataag tttgggagct gatatggtag ctgtaagtat
      901 acataaaact ggaggagcat tgacacaatc ttcagcactc ttattgaata gagataatgt
      961 aagttttgaa aaggttcttc aatcaatcaa tatgctacaa tcaacatcag catcttattt
     1021 gcttatggca agtatagatg gtgctagagt taatctagtt gagaatggtg aaaagcaact
     1081 gtcaaaagca ttaaatctat ctaggtatgc aaaatctaaa ttaaacaaaa ttgatggaat
     1141 aaaagtttta tctacagaaa tattgaaaca aaaaggtgtt aaatttatag atgaaacaaa
     1201 attgtgtata aatgtaaaag aattaaattt gactggattt gaagtatacg atttattata
     1261 taaaaatttt tcaattcaag tagaattggg agattcatat aatatactgg cacttgtgtc
     1321 cattggaaca aataaatcag atatagatag attagtaaaa gcactttcta taattgcaaa
     1381 gatttataga aaagaatcaa cattaaatga atttaatatg gttcaaataa atccaattat
     1441 taaacttaat ccaagagaag ctttttatgc accaaaggaa agtgtagaaa tcaattcatg
     1501 tatagataga atttgtggag aatcaataat ggcatatcca ccaggtatac cgattattgc
     1561 tccaggagaa ttgataacag aagaaattat ggagtatatt attttcttaa aaaatagcaa
     1621 tgcatatctt acagatgtac aagataaaaa cttagataga atattagtaa taaaataaat
     1681 tactttattt tgcaagggca agtatttgtt aagtagagtt tatcaaatag aacttattaa
     1741 aagtataaag gagttggggt tgaaatgaaa tttgaaacac taggaagaca tatactagta
     1801 gaatactata attgtgatga aaacgtactt aaagacccac gtcttataga aaattttatg
     1861 aatgattcag cattaaatgc aaaagcgaca attgtggatt ctgtattcca ccattttaat
     1921 ccttgggggg tttcaggagc tgttataatt gctgaatctc atttgacaat acatacatgg
     1981 cctgaatatg gctatgcagc agcagatttt tttacttgtg gtgatataga cccatggaaa
     2041 agttttgaat tattagagca acttttaaag tctgaaagaa gcgagtctac agaaattcca
     2101 agaggcttaa ctacaaaaat taaaaaatat tcaaaaaaag atttaggtaa gattactcat
     2161 aaaccagaag cagtataaaa catacaagag aaagtgagga ttattatatg gaactttggt
     2221 atacagaaga atggacagaa aatgtaagat tttctataaa agtaaataaa catctatttg
     2281 aaggaaagtc tcaatttcaa aggatagatg tgtttgatag tgatgaattt ggaaaatttc
     2341 taacaataga tggattaatg atggtaacat ataaagatga atttatatac catgagatga
     2401 taactcatgt tcctatggct acaaatttaa acataaagaa agtattagtc ataggtggag
     2461 gtgatggagg tacagtaaga gaattaagcc gttatcctca aatagaaaag attgacatgg
     2521 ttgaaataga taaaatggtt gtagatgtat ctaaggagta tatggatata tgctcatgta
     2581 aattagatga taaaagagtg agtttatatt ttgaagatgg tgttaatttt gttaagtgtg
     2641 cacatgataa atcatatgac ctgataatag tagattcaac tgacccaata ggaccaggtg
     2701 aagggctttt ctcaactgat ttttataagg attgttatag aatactgact gatgatggaa
     2761 ttttagtaaa tcaaagtgaa agtccgtatt ttgactttaa tgctaaagag atgaaaagag
     2821 ctaataaaaa attaaaacag atatttccaa tatcagaagt ttatcaagca catataccaa
     2881 catatccatc tggtcactgg ttgtttggat ttgcttcaaa aaaacttaat ccagtaaaaa
     2941 atcaagatag aaatggatgg gagaaattaa gtttaaaaac taaatattat aatagtgata
     3001 tacatttagg ttcgtttatg ttacctcaat acgtgaagga gatgctagat gaagaataat
     3061 ttctatcata tgaacacttt tatgagtatg gacaaaaatt atgaagaatc taatcttata
     3121 gtatttggtg ttggatttga tggaactact tctaacagac ctggggctag atttgcaagt
     3181 agctctatga gaaaagaatt ttacggtctt gagacatata gtcctttttt agatttggat
     3241 ttagaggatt ataatatatg tgattatgga gatttagaaa ttagtgttgg aagtacagaa
     3301 caagtcttaa aagaaatcta tcaagagaca tataagattg ttagagattc aaaggtaccc
     3361 tttatgattg gaggagagca tttagttaca ttaccagcct ttaaagcagt acatgaaaag
     3421 tacaatgata tatatgtaat tcattttgat gcccatactg atttgaggga agaatataat
     3481 aatagtaaaa attctcatgc aacagtaatt aaaagaatat gggatattgt aggtgataat
     3541 aaaatatttc aatttggtat aaggtctggg acaaaagaag aatttaaatt tgctacagaa
     3601 gaaaaacaca catacatgga aataggagga atagatacgt ttgaaaatat agttaatatg
     3661 ctaaatggaa agaatattta tctaactata gatttagatg tattggatgc atctgtgttt
     3721 ccaggaacag gtacaccaga acctggtggt gtaaattata gagagtttca agagattttt
     3781 aagattataa aaaactctaa tataaatata gttggttgtg acattgtaga gttaagccct
     3841 gattacgata caacaggtgt atcgacagtt atagcttgta aaatcttaag agagttatgc
     3901 ttaataatat ctgataaaat taaatagagt attttatata aatagtatat attataatat
     3961 aagaagttat tttaaaaaag ttagtttaag tttgacgctt ttctaaagta acttcttatt
     4021 tttgtaatta aaaataaata taataaacaa caaaaaagag ccctcgatag ctccttttct
     4081 aaaatatata tatttaaatt aaataattat attctattta cgttttcagc ttgaggtcct
     4141 ctattacctt gagttatatc aaagctaacc ttttcgcctt cttctaaagt tttgtatcca
     4201 tcattttgta tagctgagaa atgtacgaaa acatcatctt ctccctctac agatatgaac
     4261 ccaaatcctt tttcattgtt aaaccatttt actattccgt ttttcattat aagaaaacct
     4321 ccgcattatt aaaaaataca aactaaaaaa ataagtctgt tctattaata taacataaat
     4381 tttaaataaa agcaaataaa atttttaaaa aaattaatta cttttagaat ttaataaaaa
     4441 ttgttaaatt atacagtgag aagtattgta aaatttgacg aaaatgtaaa tgtagataat
     4501 aaatttaata tcaaaaaatg taacaaaaag gtatgtaagt aaaaagtaaa attaaaa
//
LOCUS       DAEHWM010000166         4519 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.169, whole genome shotgun sequence.
ACCESSION   DAEHWM010000166 DAEHWM010000000
VERSION     DAEHWM010000166.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4519)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4519)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4519
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.169"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     misc_binding    143..377
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            427..1446
                     /gene="pheS"
                     /locus_tag="KNP36_003618"
     CDS             427..1446
                     /gene="pheS"
                     /locus_tag="KNP36_003618"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HBF0875444.1"
                     /translation="MQEKLLALREAALAEIKEAQSIESVESLRVKYLGKKGEITAILK
                     EMGKLSAEERPVVGKVANEVRENIELSINSKKEEINAIEKERKLKEEVIDVTQPGKVL
                     KVGKKHPITQIIDEVTDIFIGMGFSIAEGPEVETVENNFDALNAPKDHPSRDMSDTFY
                     INDGVLLRTQTSPVQVRTMRSQELPIKVIAPGRCFRSDSPDATHSPMFHQIEGLVVGK
                     DVTMAEFKGTMDIFVEKLFGSDIKTKFRPHNFPFTEPSAEVDVTCFKCGGKGCPMCKY
                     EGWIEILGSGMVHPNVLRNCGIDPEVYSGFAFGVGVERLAMLKYEIDDIRLLFENDMR
                     FLNQF"
     gene            1463..3856
                     /locus_tag="KNP36_003619"
     CDS             1463..3856
                     /locus_tag="KNP36_003619"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HBF0875445.1"
                     /translation="MLVSLKWLRDYVDIDMDVKEFADKMTMTGTKVETIDYYGEEIEN
                     ILVGKILEIKQHPNADKLVVTKVDIGDKVVQIVTGATNISEGDYIPVAVNGSKLPGGV
                     EIKQTDFRGELSDGMMCSAAELGIDEHYIEEYKRGGIYILDHEDSYELGKDIKDVLGL
                     KDALIDFELTSNRPDCKCMMGIAREAAATIGTKVKYPEIEVKESDEEIDFKVEIDNPD
                     LCRRYVARMVTDVKIEPSPYWMQRRLTEAGVRPISNIVDITNFVMLELGQPLHAFDIN
                     QVETGRIVVRNAKDGEKLVTLDDVERTLDKDMLVITNGEKSLGLAGVMGGANSEITSN
                     TKTVLFESANFKPENIRMTAKKVGIRSEASSRNEKDLDPNLAEIAANRAAQLVEMLGA
                     GKVLKGVVDVYPNKPEPKKLVVNPQRINHLLGVDVPMEQFVGILESLEFKCNLVANDK
                     LEIDVPSFRTDMEQEADVWEEIARIYGFENIPSVQLEGNTTAGIKTSKQKFMDALKDN
                     STAVGLNEILTYSFVSPKGVDKIRVPEGNAKRNFVKLLNPLGEETSVMRTTLIPNMLD
                     VLSTNVSHKIEEVSAFECGHIFIPQDSELPKEENRMCVGMYGKDVDFFALKGTIETIL
                     VNVGFKGYEIEPQDNNTTFHPGRCAKIVYNNKYVGTLGELHPDVIENYNLGQRVYVAE
                     IDIDFVFDNSDRTKNYVPLPKYPSTSRDIALIVKDDVFVKQIEDIIKENGQGLVESYK
                     LFDVYKGSQIEAGYKSIAYSITYRSKDKTLTDEDVAKVHDKILSELSEKLNANLRSN"
     gene            3881..4471
                     /gene="zapA"
                     /locus_tag="KNP36_003620"
     CDS             3881..4471
                     /gene="zapA"
                     /locus_tag="KNP36_003620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HBF0875446.1"
                     /translation="MNKVMVKIHGAEYPMVGDKSEKFMISIADFVDKEMDKITRQNPK
                     LSLSVAAILTALNISDLLFECSDENEKLIKANEELSKKVGASNEELQLEIKSLKLTIA
                     EKEAENREAETKMKELIEIIENKKQEIFELSNTTEGSRAELDAYKNKIEELSTQLEEA
                     NERATIAENLASEFQNKAYDLQLKCTGLNNDAKNVE"
BASE COUNT         1788 a          521 c          922 g         1288 t
ORIGIN      
        1 ataaaaaata attgagttaa ttatgcatta gatatatatt atataaaaaa taattaaatt
       61 aattatgtat tggatatata ttaaaaatag tcacataatt tgaatggaaa tgatataata
      121 ctaaaataaa caatataata ttgtaaatgc aatgaaagag gaaagtattt tgattaaact
      181 tagtaaagag ataaacacct aggctgggag tgttttctaa gaggtcatga gaagttccct
      241 ctggagtaac agagctgaaa ttttacagta ggctttgacg tcaaaaacgc gttaagtttg
      301 ttagaggtgg tttgatgatt tttaaattgt taaactacta gggtggtacc gcgaaactat
      361 agcctttcgt ccctagacag ggattgaggg gcttttttta tacaaaaaaa cgaaagggtg
      421 atatgtgtgc aagaaaaatt acttgcttta cgtgaagcag ctttggctga aataaaagaa
      481 gcacaaagca tagaaagtgt agaaagttta agagttaagt acttaggaaa aaaaggtgag
      541 ataactgcca tacttaaaga aatgggtaaa ttatctgctg aagaaagacc agtagttggt
      601 aaggttgcca atgaggtaag agaaaacatt gaacttagca taaattctaa aaaagaagaa
      661 ataaatgcta ttgaaaaaga aagaaaatta aaagaggaag tgatagatgt tactcaacca
      721 ggaaaagttt taaaggttgg gaagaagcat ccaataactc aaattataga tgaagtaaca
      781 gatatattta tcggaatggg attctctata gcagaagggc cagaagttga gactgttgaa
      841 aacaactttg acgcattaaa cgctcctaaa gaccatccat caagagatat gagcgataca
      901 ttctatatca atgatggggt attacttaga actcaaacat ctccagttca agtaagaact
      961 atgagaagtc aagagttacc aataaaagta attgcaccag gtagatgttt taggtcagac
     1021 tcgccagatg ctacacactc accaatgttc catcagatag aagggcttgt tgttggaaaa
     1081 gatgttacta tggcagaatt taaaggaact atggatatct tcgttgaaaa attgtttggt
     1141 tctgatatca aaactaagtt tagacctcac aacttcccat ttacagaacc aagtgcagag
     1201 gttgatgtta cttgtttcaa atgtggtggt aaaggttgcc caatgtgtaa atatgaaggt
     1261 tggatagaaa tattaggttc aggtatggtt catccaaatg tgcttagaaa ttgtggaata
     1321 gacccagaag tttacagtgg atttgcattt ggagttgggg ttgaaagact tgcaatgctt
     1381 aaatacgaaa tagatgatat tagattatta ttcgaaaatg atatgagatt cttaaatcaa
     1441 ttttaattag gagggtatgt agatgttagt atctttaaaa tggcttagag actatgttga
     1501 tatagacatg gatgtaaaag agttcgctga taaaatgaca atgacaggaa ctaaagttga
     1561 aacaatagat tattatggtg aagaaataga aaatatattg gttggaaaga ttttagaaat
     1621 aaaacaacat ccaaatgctg ataagttggt tgtaactaaa gtagatattg gagataaagt
     1681 tgttcaaata gttacaggag ctacaaatat atcagaagga gattatattc cagtagctgt
     1741 aaatggttct aagttacctg gaggagttga aatcaaacag actgatttca gaggtgaatt
     1801 atcagatggt atgatgtgtt cagcagctga actaggtata gatgaacatt acattgagga
     1861 gtataaaaga ggtggtatat atattttaga ccacgaagat tcttatgaat taggaaaaga
     1921 tataaaagat gttttaggat taaaagatgc tttaatagat tttgaattaa cttcaaacag
     1981 acctgattgt aaatgcatga tgggtatagc tagagaagca gctgcaacta taggaacaaa
     2041 agtaaaatat cctgaaatcg aagtaaaaga aagtgacgaa gagatagatt tcaaagttga
     2101 gatagataat ccagatttat gtagaagata tgttgctaga atggttacag atgtaaaaat
     2161 agaaccttct ccatattgga tgcaaagaag acttacagaa gcaggagtaa gacctataag
     2221 taacatagtc gatataacaa acttcgtaat gttagagctt ggtcaaccac ttcatgcttt
     2281 tgatataaat caagtagaga ctggaagaat agtagtaaga aatgctaaag atggagagaa
     2341 acttgtaaca ttagatgatg ttgagagaac attagacaaa gatatgctag ttataacaaa
     2401 tggagaaaaa tcacttggtt tagctggtgt aatgggtggt gctaactcag aaataacttc
     2461 taatacgaag actgtacttt ttgaaagtgc caatttcaaa ccagaaaaca taagaatgac
     2521 agctaaaaaa gttggtatta ggtcagaagc atcttcaaga aatgaaaaag acttagaccc
     2581 taatcttgca gagatagcag caaatagagc tgcacaactt gttgaaatgt taggagcagg
     2641 aaaagtttta aaaggtgttg tagatgtata tccaaataaa ccagaaccta aaaaattggt
     2701 agtaaatcct caaagaatta accacctatt aggtgtagat gtaccaatgg agcagtttgt
     2761 aggaatttta gaatcattag agtttaaatg taatttggta gctaatgata aattagaaat
     2821 agatgtacca agctttagaa cagatatgga acaagaagct gatgtatggg aagaaatagc
     2881 tagaatttat ggatttgaga atataccttc tgtacaatta gaaggaaata cgacagcagg
     2941 aattaaaact tcaaaacaaa aattcatgga tgctttaaaa gataattcaa ctgctgtagg
     3001 attaaatgaa atattaacat attcatttgt aagccctaag ggagtagata agataagagt
     3061 accagaaggt aatgcaaaga gaaattttgt taaattactt aacccattag gagaagaaac
     3121 ttctgtaatg agaactactt taataccaaa tatgttagat gttttatcaa ctaatgtatc
     3181 tcataaaata gaagaagtat ctgcatttga gtgtggacat atattcatcc cacaagattc
     3241 agaattacct aaggaagaaa atagaatgtg tgtaggtatg tatggtaaag atgttgactt
     3301 ctttgcacta aaaggaacta tagaaactat acttgtaaat gtcggattta aaggttatga
     3361 aattgaacct caagataata atactacctt ccaccctggt agatgtgcta aaatagtgta
     3421 taataataaa tatgtaggta cattaggtga attgcatcca gatgttatag aaaactacaa
     3481 tctaggtcaa agagtttatg tcgctgaaat agatattgac tttgtatttg ataattctga
     3541 tagaacaaag aattatgtgc cattaccaaa atatccatct acatcaagag atatagctct
     3601 tattgttaaa gatgatgtat ttgtaaaaca aatagaagat ataataaagg aaaatggtca
     3661 aggattagta gaaagctaca agttatttga tgtttacaaa ggttctcaaa tagaagctgg
     3721 atacaagtca attgcatatt caataactta tagaagtaaa gataaaactc taacagatga
     3781 agatgtagct aaggtgcatg ataagatatt aagtgaatta agcgaaaaat taaatgctaa
     3841 cttaagatca aattaacaac taatgtcggg ggaggttagg atgaacaaag taatggttaa
     3901 aatccatggc gctgaatatc caatggttgg agacaaatca gagaagttta tgattagtat
     3961 tgctgatttt gtagacaaag aaatggataa aataacacgt caaaacccga aattgagctt
     4021 atcagttgct gcgatattaa ctgcattaaa tatatcagac cttttatttg aatgttcaga
     4081 tgagaatgag aagttgatta aagcgaatga agaattgagt aagaaggttg gagcatctaa
     4141 tgaagagctt caattagaaa tcaaatcttt aaagcttacg atagcagaaa aagaagcaga
     4201 aaatcgtgaa gctgaaacta agatgaaaga gttaattgag attatagaaa ataaaaagca
     4261 agaaatattc gaacttagta atacgacaga aggttctaga gcagagttag atgcttataa
     4321 aaacaagatt gaggagttaa gtactcaact tgaagaagca aatgaaagag ctactatagc
     4381 tgaaaactta gcttctgagt ttcaaaacaa agcttatgat ttacagttaa aatgtacagg
     4441 gttaaataat gatgcaaaaa atgtggaata aactaaaaga tttgctgtct cttgtttttt
     4501 gagacagctt cttttaatg
//
LOCUS       DAEHWM010000167         4432 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.170, whole genome shotgun sequence.
ACCESSION   DAEHWM010000167 DAEHWM010000000
VERSION     DAEHWM010000167.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4432)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.170"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     repeat_region   31..2833
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=31..60
                     /rpt_unit_seq="gttaaacagtaacatgagatgtatttaaat"
     gene            2918..3412
                     /locus_tag="KNP36_003621"
     CDS             2918..3412
                     /locus_tag="KNP36_003621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cas4"
                     /protein_id="HBF0875447.1"
                     /translation="MKITGTLINYYFHCKRQCWLLGNRINLEENSEDVKIGRLLHELK
                     EEKTKYKEIAIENIKIDKLTREYLVEVKKSDADIEAVKWQVLLYLKKLKEKGIVRKGK
                     IEFIEKNKTNKKIVFVDLSEVSEEQLISIEREIVNLINSDKAPCPDLKKGCKKCAYYE
                     YCYI"
     gene            3447..>4432
                     /gene="cas1b"
                     /locus_tag="KNP36_003622"
     CDS             3447..>4432
                     /gene="cas1b"
                     /locus_tag="KNP36_003622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated endonuclease Cas1"
                     /protein_id="HBF0875448.1"
                     /translation="MGKTKYITSMGELTRKDNSICFRKNGRNVYIPVENTSEIFCLNE
                     VSLNSKLLDFLSRANIVVHFFNYYGGYSGTFYPKEYLISGKVTVAQVKTFEDRREEIA
                     KSIVNGIRINAINTLSHYYKHGNSEIQPLLSHLKKDSINKLEKSNNIKEILSVEGDIW
                     QTFYTSFKYILREEFIFNKRVKRPPDNPLNAMISFGNSILYAKTVTAIYNTHLNQSVS
                     FLHEPSESRFSLSLDLSENFKHVITFKTIFDLVNNRKINIEKHFDKNLNYCVLNDEGK
                     QIFINSLEERLESVKEHPKLKRKVSLKTCIKLDAYKMLKCIMEEKSFIPYNI"
BASE COUNT         1850 a          478 c          661 g         1443 t
ORIGIN      
        1 cataattaaa tcgtagtcaa taccgtacag gttaaacagt aacatgagat gtatttaaat
       61 ctctgaatag ccaatcaact ttgctgcatt actcttgtta aacagtaaca tgagatgtat
      121 ttaaatgata atagttatat atatttttta caatatatta ttgttaaaca gtaacatgag
      181 atgtatttaa atttacttct cctgttttga aatctatata ttcatcatgt taaacagtaa
      241 catgagatgt atttaaatat aatattgata caaatatttt gggtaaatgg acttgttaaa
      301 cagtaacatg agatgtattt aaattcgata tggtaacaaa tttataaaag atatagaatg
      361 ggttaaacag taacatgaga tgtatttaaa ttaataatgc acctatttta acagtacctg
      421 gtctaaagtt aaacagtaac atgagatgta tttaaattca agtctaggag acaacataaa
      481 tagtacagat gggttaaaca gtaacatgag atgtatttaa attagtaaaa ccagatggaa
      541 ctgttgtaat accaccaaag ttaaacagta acatgagatg tatttaaatt taaaaacatc
      601 ttgaggaata tctttaacag taattgttaa acagtaacat gagatgtatt taaatgcatt
      661 ttcaggtgca tgataaatag gtaaattaga tgttaaacag taacatgaga tgtatttaaa
      721 ttttttgtaa ttagccagat tatcaactcc caaaatagtt aaacagtaac atgagatgta
      781 tttaaattaa atatcgtcct tcgtagttaa agcaacacca gaaggttaaa cagtaacatg
      841 agatgtattt aaatcgtaaa caaaatttat caagagaaga atttctaagg ttaaacagta
      901 acatgagatg tatttaaatt tatatttgat aagagtatca aatcgactta aaatagttaa
      961 acagtaacat gagatgtatt taaattcaat cttaatacac agacattttt aaaaacaaaa
     1021 cgttaaacag taacatgaga tgtatttaaa taaatagaca aatattgaat agctctgtct
     1081 tcatcaagtt aaacagtaac atgagatgta tttaaatata tttacaaaat ctctaacata
     1141 ttttttaact tctgttaaac agtaacatga gatgtattta aattctttta aagagtcctc
     1201 gggagcctcg aaaacttcag ttaaacagta acatgagatg tatttaaatt actcaaataa
     1261 atttctaatt tgtttatcta ctaacgttaa acagtaacat gagatgtatt taaattagaa
     1321 tttacaacaa tataagcctc tttaaccata agttaaacag taacatgaga tgtatttaaa
     1381 tatgttttta gtagtacatt taataaaact ttttaaagtt aaacagtaac atgagatgta
     1441 tttaaatgaa ggaaccgtac cttgataaat cacgaccgta cccgttaaac agtaacatga
     1501 gatgtattta aattgtatat ttgatgttgt tatttctcct gtgtataatg ttaaacagta
     1561 acatgagatg tatttaaatg aagttccacc cccaccaccc ccactacttt gagaagttaa
     1621 acagtaacat gagatgtatt taaattaaca atagagtaaa tataataaac aagcatacaa
     1681 agttaaacag taacatgaga tgtatttaaa tccccttttg catggtacta gacacgcata
     1741 tatggtggtt aaacagtaac atgagatgta tttaaatacg cctatatgcg gagtaacaga
     1801 tttttgcctg gatggttaaa cagtaacatg agatgtattt aaatactgtt ttgggataga
     1861 ctggaattaa atggtctgtg ttaaacagta acatgagatg tatttaaatt tttggaatga
     1921 agcatcaaca gataataaag aaaaagttaa acagtaacat gagatgtatt taaatcaagg
     1981 aaacaaaaga gaagtgaaaa gaaatataat gttaaacagt aacatgagat gtatttaaat
     2041 aatcttttaa atggaaatta agtaataaaa gagagggtta aacagtaaca tgagatgtat
     2101 ttaaattcaa ttaaataagc attaatctta gtaaaatcaa acgttaaaca gtaacatgag
     2161 atgtatttaa attttcttgt gttaattgaa cccccatttt aagctccagt taaacagtaa
     2221 catgagatgt atttaaatca gaatacagct tctatatctg gatacatttg tcttggttaa
     2281 acagtaacat gagatgtatt taaatgtgaa aagtaataca ggtatagagt ctaaacgctc
     2341 ggttaaacag taacatgaga tgtatttaaa tcaatgtatc ctctttttta gttttggagc
     2401 ctcttttgtt aaacagtaac atgagatgta tttaaattag ttagcacatt ttatttcaag
     2461 ccttaaaaca ttcgttaaac agtaacatga gatgtattta aattaatttg cacacttaac
     2521 ctctaatctt aaagtattag ttaaacagta acatgagatg tatttaaata acacaatatt
     2581 atctttaata gaattaaaca aatgagttaa acagtaacat gagatgtatt taaatttttg
     2641 ttggtcttgt gcttctttta aaagctgatt agttaaacag taacatgaga tgtatttaaa
     2701 tttaaaaagt tctgttatta aaacatccaa accaatcgtt aaacagtaac atgagatgta
     2761 tttaaattct gtaccatcta gccaaaccgt ttttgaagtt aaagttaaac agtaacataa
     2821 gatgtatcta aattactcta tcataaaatt ttaatatatt aaacaaacta atatgtgata
     2881 tacttatgta taaataacaa aataaatagg tgatgttatg aaaattacag gaactttgat
     2941 aaattactat ttccattgta aaagacaatg ctggttgctt ggtaatagaa taaatttgga
     3001 agaaaatagt gaagatgtaa aaataggtag acttcttcat gaactaaaag aagaaaaaac
     3061 aaaatataaa gaaattgcaa ttgaaaatat aaaaatagac aaattaacaa gagaatattt
     3121 agtagaggtt aaaaagtctg atgctgatat agaagctgtt aagtggcaag ttcttttata
     3181 tttaaaaaag ttaaaagaaa agggaattgt aagaaaaggg aaaattgaat ttatagaaaa
     3241 aaataaaact aataaaaaaa tagtctttgt agatttgagt gaagtatctg aagaacagct
     3301 tatatctata gaaagagaaa ttgttaattt aataaatagt gataaagcac catgtcctga
     3361 tttaaaaaaa ggatgtaaaa aatgtgccta ttatgaatat tgttatatat aaagaggtat
     3421 aagaaacata taaggaggtg ttaatattgg gaaagacaaa atatattacc tcaatgggtg
     3481 aactcacaag aaaagataat tctatatgtt ttagaaaaaa tggaaggaat gtatatatac
     3541 cagtagaaaa tactagtgaa atattctgtc taaatgaggt atctttaaat tcaaaattac
     3601 tggatttttt atcaagagca aatattgttg ttcatttttt taattactat ggtggatata
     3661 gtggaacttt ttatcctaaa gaatatttaa taagtggaaa agtaacagtg gcacaggtaa
     3721 aaacctttga agatagaaga gaagaaatag caaaatccat agtcaatggt ataaggatta
     3781 atgcaataaa tacattatcg cattactata agcatggaaa ttcagaaata caaccattat
     3841 tatcacatct aaaaaaagat tctataaaca agttagaaaa atcaaataat ataaaagaaa
     3901 tattatcagt cgaaggagat atttggcaaa cattttatac ttcctttaag tatattttaa
     3961 gagaggaatt tatttttaat aaaagagtta agagaccacc agataatccc ttaaacgcaa
     4021 tgatatcatt tggtaacagt attttatatg ctaaaactgt aactgctata tataatacac
     4081 atctaaatca aagtgtaagt tttttacatg aaccaagtga aagtagattt tctttaagtc
     4141 tagatttaag tgaaaatttt aaacatgtta taacttttaa aactatattt gatttagtta
     4201 ataatagaaa aataaatatt gaaaaacatt ttgataaaaa tttgaactac tgtgttctaa
     4261 atgatgaagg aaagcaaatt tttataaatt ctttagaaga aagattagaa tcagtcaaag
     4321 aacatccaaa attaaaacga aaagtaagtt taaaaacctg tataaaatta gatgcttaca
     4381 aaatgttaaa gtgtataatg gaagaaaaaa gttttattcc atataacata aa
//
LOCUS       DAEHWM010000168         4362 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.171, whole genome shotgun sequence.
ACCESSION   DAEHWM010000168 DAEHWM010000000
VERSION     DAEHWM010000168.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4362)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4362)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4362
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.171"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            31..669
                     /locus_tag="KNP36_003623"
     CDS             31..669
                     /locus_tag="KNP36_003623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003356606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate utilization protein"
                     /protein_id="HBF0875449.1"
                     /translation="MDQNLNWLNEKRIEKTIKSLENNNMKGYLVSNKEELLKKIEEIV
                     KAGSLVGCGGSMTLFETGVIDFIREKYNFLDRYAKDIKPEEMKEIYRKSFSADAYFTS
                     TNAITEDGELYNLDGNGNRVAAMIYGPDKVIVIAGVNKIVKDVDEAIKRTKTIAAPAN
                     CKRLSTNTGCKTTGICIDCSSPGRICCSYTLIKRQLTPERIHVIFLNEDFGY"
     gene            696..1595
                     /locus_tag="KNP36_003624"
     CDS             696..1595
                     /locus_tag="KNP36_003624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YegS/Rv2252/BmrU family lipid kinase"
                     /protein_id="HBF0875450.1"
                     /translation="MKKVKLIYNPNSGEKKILSNLDTIIELYQEKNYLLIPYRLTIKE
                     PVKNAFKEVDSSYEHILIAGGDGTVDLVVNAMKELDIKIPIGILPTGTANDFSNALQI
                     SFDIKEAINEIINSKPKKIDIGKVNNKYFINVASAGMFTDVSQRINTDLKNSFGRISY
                     YIKGIEEALYMRKFKIKVSSEEMYYDGDMYLMLIFNGKTAGNINLAYKAEIDDGYLDV
                     IIFKGMPIPKSIPVLISVLRGDYLDQYNGNEILYFKTKKVHIECEDSLITDIDGEKGP
                     DFPLNIECIKDGIEVMGICSEKS"
     gene            complement(1702..3366)
                     /locus_tag="KNP36_003625"
     CDS             complement(1702..3366)
                     /locus_tag="KNP36_003625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--tRNA ligase/YqeY domain fusion
                     protein"
                     /protein_id="HBF0875451.1"
                     /translation="MSNETNSSNFIKNIIINDLETGKHDSIITRFPPEPNGYLHIGHA
                     KSICLNFGLAKEFNGKANLRFDDTNPLKEDVEYVESIKEDVKWLGFDWNELNFASNYF
                     DEMYKRALILIKKGKAYVCDLTQEEMREYRGTLTEPGKESPHRNRTIEENLDLFERMK
                     NGEFKDGEKTLRAKIDMSSPNINLRDPIIYRISHSTHHNTGDKWCIYPMYAFAHPIED
                     AIEGITHSICTLEFEDQRPLYDWFVKECEMENIPRQIEFARLNINNTVMSKRKLKQLV
                     DEGIVDGWDDPRVPTISGIRRKGYTAEALRNFCSEIGVSKVNSTVDSQMLDYFLRENL
                     QPKAPLTMGVLRPLKLIITNYPEDKIEMLEIENNAKDESQGKRLVPFSRELYIEQDDF
                     MEEPVKKYFRFFPGNEVRLKGAYFVKCTDVIKDENGNVVEIHGTYDPETKSGSGFTGR
                     KVKSTIHWVDAKSAIPCEFRLFEPLILDDIPENEGKHFLKQINPNSLEILQGFVEPTQ
                     IKDAKPFDKFQFVRNGFFSIDNKYTTDEKFVFNRIVPLKSSFKPGK"
     gene            3658..>4362
                     /locus_tag="KNP36_003626"
     CDS             3658..>4362
                     /locus_tag="KNP36_003626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428988.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2140 domain-containing protein"
                     /protein_id="HBF0875452.1"
                     /translation="MGKVAKILLSLIVIVLVLAGIVVYILTPKERYDVSSQNNKIIDE
                     EYLSKGSYINSMEVVKNPLRMVGKISVSEEEFKNLIYTLMQKHGINELENNFVEMKNG
                     KIKVAGPYKVFGLVNSQYELELRPTLKDGNLVVSLENVKIGKFKLSDKMLEKILSNYN
                     KKVPFEVNGNKITLEKSYLYPITLKNISIKKGNVDLDMEVEIDLKSQINGALGYLKDS
                     GKVQDILNHLINLKKTS"
BASE COUNT         1650 a          542 c          681 g         1489 t
ORIGIN      
        1 gtgcatatta aaaataaggg ggaagttaaa atggatcaaa atttaaattg gcttaatgaa
       61 aaaagaatag aaaaaacaat aaaatctttg gaaaacaata atatgaaagg gtatttagta
      121 agtaacaaag aagagcttct taaaaaaatt gaagaaatag ttaaagcagg ttctctagta
      181 ggatgtggag gttctatgac cttatttgaa acaggagtga ttgattttat aagagaaaaa
      241 tataattttc ttgatagata tgcaaaagat atcaaaccag aagaaatgaa agaaatatat
      301 agaaagtcat tttctgcaga tgcttatttt acaagtacta atgcgataac agaggatgga
      361 gaactttaca atttagatgg gaatgggaat agagttgctg ctatgatata tggacctgat
      421 aaagtaatag ttatagcagg agtaaataaa atagttaaag atgtagatga agctataaaa
      481 agaacaaaaa caatagctgc tccagccaat tgtaaaagat taagtacaaa tactggatgt
      541 aagactactg gtatatgtat agactgttca agtccaggaa gaatatgctg tagttataca
      601 cttataaaaa gacaattaac accagaaaga atacatgtga tttttttaaa tgaagatttt
      661 ggatactaaa agaataaaat gagtaaggag aaataatgaa aaaagtaaaa cttatataca
      721 atcctaattc aggtgaaaaa aagatattat caaatttaga cactatcata gaattatatc
      781 aagaaaaaaa ttatttattg ataccctata gattaactat taaagaacct gtaaagaatg
      841 catttaagga agttgatagt tcttatgaac acatattgat agctggtggt gatggtactg
      901 tagatttagt agtaaatgca atgaaagaat tagacataaa aattccaatt ggaattttgc
      961 ctacaggaac tgcaaatgat ttttcaaatg ctcttcaaat ttcatttgat ataaaagaag
     1021 ctataaatga aatcataaat tcaaaaccaa agaaaataga catagggaaa gtcaataata
     1081 agtactttat aaatgttgca agtgctggta tgtttacgga tgtatcacaa aggataaaca
     1141 cagacttaaa aaattcattt ggaagaattt cttattatat aaagggaata gaagaagcat
     1201 tgtatatgag gaaatttaag ataaaagtat cttctgagga aatgtattat gatggagata
     1261 tgtatcttat gttgattttt aatggcaaaa cagcaggaaa tataaatcta gcatataagg
     1321 ctgaaataga tgatggatat ttggatgtaa ttatttttaa aggaatgcca ataccaaaat
     1381 caataccagt tttgataagt gtgcttagag gtgattattt agatcaatat aatggaaatg
     1441 aaatactata ctttaaaact aaaaaggtgc atatagaatg tgaagattca cttataacag
     1501 atattgacgg agaaaaagga ccagattttc ctcttaacat agaatgcata aaagatggaa
     1561 tagaagtcat gggaatctgt agtgaaaaaa gttaatcatt taaagtaaat gatgaagact
     1621 caaataaaaa attacttcta actaagttta tttatagtag aagtaattta tattttaagt
     1681 cttcattttt tgattgtaag attatttacc tggtttaaaa gaacttttta gaggaactat
     1741 tctattaaat acaaattttt catcagttgt atatttatta tctatactaa agaatccatt
     1801 tctaacaaat tggaatttat caaaaggttt agcatctttt atctgtgtag gttcaacaaa
     1861 accttgtaat atttccaatg aattaggatt tatttgtttt aagaaatgtt taccttcatt
     1921 ttcaggtata tcatcaagaa ttaatggttc aaataatcta aattcacatg gtatagctga
     1981 tttagcatca acccaatgta ttgtagattt taccttacgt cctgtaaagc cagagccact
     2041 cttagtttca gggtcataag taccatgtat ttcaactaca tttccatttt catccttaat
     2101 tacatcagta cattttacaa aataagcacc ttttaaacgg acttcatttc ctgggaaaaa
     2161 tctaaaatat ttcttaacag gttcttccat aaaatcatct tgttctatat acaattctct
     2221 agagaaagga actaatctct ttccttgaga ttcatcttta gcattattct ctatttcaag
     2281 catctcaatc ttatcttctg ggtaattagt tataataagt tttaaaggtc ttaaaactcc
     2341 catagtaaga ggagcctttg gttgtaagtt ttctcttagg aaataatcaa gcatttgact
     2401 atctaccgta gagttaactt ttgatacccc tatttcacta cagaaattgc gcaatgcttc
     2461 tgcagtatat cccttacgtc tgattccgga tattgtagga acacgagggt catcccaacc
     2521 atcaacaata ccctcatcta caagttgttt taatttcctt ttactcatga cagtattatt
     2581 tatattaagt ctagcaaatt ctatttgtct aggtatattt tccatctcac attctttaac
     2641 aaaccaatca taaagaggtc tttggtcttc aaactctaaa gtacatatag agtgagttat
     2701 tccttcaatt gcatcttcaa ttggatgagc aaaagcatac ataggatata tgcaccattt
     2761 atctcctgta ttatggtgtg ttgaatgaga tattctatat ataattgggt ctctaaggtt
     2821 tatatttgga gaagacatat ctattttggc tcttaatgtt ttttcaccat ctttaaattc
     2881 accatttttc attctttcaa ataaatcaag gttttcttca atagttctgt ttctatgagg
     2941 actttctttt cctggttcag ttagagtacc acgatattct ctcatttcct cttgtgtcaa
     3001 atcacataca taagctttac ccttttttat tagtattaaa gctctcttat acatttcatc
     3061 aaagtagtta gatgcaaaat ttaactcgtt ccaatcaaat cctaaccact ttacatcttc
     3121 ttttatggac tctacatatt caacatcctc ttttaatggg tttgtatcat caaatcttaa
     3181 attagctttt ccattaaact ccttagctaa tccaaaatta agacatatac tttttgcatg
     3241 accaatatgt aaatatccgt ttggctcagg tggaaaacga gttatgatac tgtcatgttt
     3301 tcctgtttct aagtcgttta taataatatt ctttataaag ttagatgagt tcgtttcatt
     3361 tgacatattc tatacctcct atttaatttg attataatac agaacactac actgtattgc
     3421 ataatattaa ttttaatcca agattagaaa aaaataaagg tgtaattaag agtattatgc
     3481 aaaatattaa cttttatact aaaaacatgt ttttacagtt tatttacaaa acattagatt
     3541 ggttgaatta atttttaaaa gactgtatta tagtatgtat attgttaaga atattatgtg
     3601 aagttagtta tctaaattta ttttaaatct gatgacagat ttgtaaagga gacgattatg
     3661 ggaaaggttg caaagatttt gttaagttta attgttattg ttttagtact tgcaggaatt
     3721 gttgtatata tcttgacacc aaaagaaaga tatgatgtta gttcacaaaa taataaaatc
     3781 atagatgaag aatatttatc aaaaggctca tatataaatt ctatggaggt agtaaaaaat
     3841 ccacttagaa tggttggaaa aatatctgtt tcagaggaag agtttaaaaa tttaatatat
     3901 acattgatgc agaagcatgg aattaatgaa cttgaaaata attttgttga aatgaaaaat
     3961 ggtaaaataa aggtagcagg accatataag gtatttggtt tggtaaatag tcaatatgaa
     4021 cttgaattga gacctacttt aaaggatgga aacttagttg taagtcttga gaatgtgaaa
     4081 attggaaaat ttaaactaag tgataaaatg ctagaaaaaa tattaagtaa ctacaataaa
     4141 aaagttccat ttgaggttaa tggaaataag attactttgg aaaaaagtta tctttaccca
     4201 ataacactta aaaatatatc tataaaaaaa ggaaatgttg atttggatat ggaagtagaa
     4261 atagatttaa aatcacaaat aaatggggca ttaggatatt taaaggactc tggaaaggtt
     4321 caagatatac taaatcatct gattaatttg aagaaaacat ct
//
LOCUS       DAEHWM010000169         4263 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.172, whole genome shotgun sequence.
ACCESSION   DAEHWM010000169 DAEHWM010000000
VERSION     DAEHWM010000169.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4263)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4263)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4263
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.172"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1147
                     /locus_tag="KNP36_003627"
     CDS             <1..1147
                     /locus_tag="KNP36_003627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="CRISPR-associated protein Cse4"
                     /protein_id="HBF0875453.1"
                     /translation="NIYNKNDFNVIIDGKNYGLPNDNMQLNEKKPFLKLKTRIRNSTP
                     YLISDDEVLLQKAFFDYLTNKAANGEEVIYISSEKGIHRKTDIPNEFSGYILRIKKGK
                     ELEIHDFDTVVNLNTKIKRINVECIIPIEYERHNLKPNLEIGYINNLIKLEKTIDTVF
                     FNKFMCNSYFKEIKNINLSDLVLRDILIRHREGLYTWFYKGRDSIVKQTFSNYSMGII
                     ENSIKNNNYIRAKEQYNLRIAIINYFHGGSNMADKIKVISESLFEKINSIKTKCIQSD
                     EEYYFAVGQLASYFISKNKSKNKNHSLINPILNAQNRKKIMLEIEKLFKKYNYDISYD
                     NNRRFKNLYSMIVGYEVEEKKVNRDLLIGGYLYYNLIYTKSEENENE"
     gene            1134..2129
                     /locus_tag="KNP36_003628"
     CDS             1134..2129
                     /locus_tag="KNP36_003628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I CRISPR-associated protein Cas7"
                     /protein_id="HBF0875454.1"
                     /translation="MKMNRRVYGVLGIKSIMSNWNADFSGYPKTTSTGEVFGSDKALK
                     FPMKKMWENEGEKVLYVKSLKIDESKKGEIKIRPKSLKERYEELFDIEDLKLEKNQQK
                     VLENLFKAIDVKNFGATFAEEGNNIGIMGAVQIGQGFNKYEDINVEEQQILSPFRDPK
                     AKDKKKSTNEEEKEDANSTTLGKKIVSDEAHYFYPFSINPKAYEVFVNMGVTDGYTKN
                     DYKKFKEAALVSATAFNTNSKLGCENEFALFVETDEELYLPDLAQYITFEKREKSKDL
                     ICINIIHLIAELKDDIKSVEIYYNPYKIEIKPFKDEILPKIDKVKFMNIFTRKEV"
     gene            2131..2871
                     /gene="cas5b"
                     /locus_tag="KNP36_003629"
     CDS             2131..2871
                     /gene="cas5b"
                     /locus_tag="KNP36_003629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I-B CRISPR-associated protein Cas5"
                     /protein_id="HBF0875455.1"
                     /translation="MEVLKFNLSGKTAFFKKPDVNSIIYFTYGNIHKIALMGILGACL
                     GLGGYNQQSKEDEYPEFYSLLKDIKMSIVPKHEFGYINKKVHIFNNSVGYASKEEGGN
                     LIIKEQWLENVSWDIYIQLEDSTTSRELKRRFLSNKFVYIPYLGKNDHIANISEIEII
                     TDFYKTEDINRVDSFFIREDFEFEKSYFDDNDDYKEPFKYQEKLPYRLHRMTNQYILE
                     TIIFTNMSVKLINKKEVYQVKGLNLIFI"
     gene            2895..>4263
                     /locus_tag="KNP36_003630"
     CDS             2895..>4263
                     /locus_tag="KNP36_003630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endonuclease Cas3''"
                     /protein_id="HBF0875456.1"
                     /translation="MYFKKVELFDISNNINNCKNIYAHINKDRKPETLKEHSDLSYSY
                     LMKLCVKKDLSSCLERIENKFFKKDSFLSKNFYREIILNMVYMHDIGKINSSFQFVKM
                     QNKNFKKISLRYTKHSFISSMLYFDYYFEKLKKYDFEEKKILSLFLMINTYTISKHHG
                     VLKSFKEFLFLFKDEFINIKENFKDLFKNNYNLELKSVPKTIEKMVRGVEAYLDDSHI
                     KDNLAIDLYIYSKLMFSIVTSCDFYATSEYNSGNSIDDFGTIDNYNKYYDVLKKSEIY
                     KGMKKYREYLNNNSECPYKENDINRLRTEMSIEAEDAITHNTRKRIFYLEAPTGSGKT
                     VTSINLALKSIELNQSLKKIFYIFPFNTLVEQTKDVFINEIFNSVKDIQKDVVVINSI
                     TPIQTEDKEEDNKNVEYCVTKQEIDYDKSLLNRQFLHYPIVLTTNIGFFNYLFGVSRE
                     ECFPLI"
BASE COUNT         1863 a          376 c          660 g         1364 t
ORIGIN      
        1 aaatatatat aataaaaatg atttcaatgt aattattgat ggtaaaaact atgggttacc
       61 aaacgataat atgcaattaa atgaaaaaaa gccatttttg aaattaaaaa caagaattag
      121 aaattcaact ccttatttga ttagtgatga tgaagttttg ttacagaaag ctttttttga
      181 ttatctaacg aataaagcag cgaatggaga agaagtaata tatataagta gcgaaaaggg
      241 aattcataga aaaactgata taccaaatga atttagtggt tatatactga gaataaaaaa
      301 gggtaaagaa ttagaaatac atgattttga tactgtggta aatttaaaca ctaaaataaa
      361 aagaataaat gtagaatgta taataccaat agaatatgaa agacataatt taaaaccaaa
      421 tttagagata ggatatatta ataatcttat aaaattggaa aaaacgattg atactgtatt
      481 ctttaataaa tttatgtgca atagttattt taaagaaatt aaaaatataa acttaagtga
      541 tttagttcta agggatatac ttattagaca tagagaaggt ttatatacct ggttttataa
      601 agggagagat agtatagtaa agcaaacttt ttcaaactat tctatgggta taattgaaaa
      661 ttctataaaa aacaataact acataagagc aaaggagcaa tataatttaa gaatagctat
      721 aataaattat tttcatggag gaagtaatat ggcagataaa ataaaagtta ttagtgaatc
      781 tttatttgaa aaaataaatt ctataaaaac gaaatgtata caaagtgatg aagaatatta
      841 ttttgcagtt gggcaattag catcgtattt tatatctaaa aataagtcaa aaaataaaaa
      901 tcattctctg attaatccta tactaaatgc acaaaataga aaaaaaatca tgttagagat
      961 agaaaaatta tttaaaaaat ataattatga tataagttat gacaacaata ggcgatttaa
     1021 gaatctatat tctatgattg taggatatga ggtagaagaa aaaaaagtta atagagattt
     1081 attaattggt ggatatctat attacaattt aatatacaca aaaagtgagg agaatgaaaa
     1141 tgaatagaag agtatatgga gtattaggta taaaatctat aatgtcaaac tggaatgctg
     1201 atttttctgg atatccaaag acgacatcaa caggagaagt ttttgggagt gataaagcac
     1261 ttaagtttcc catgaaaaaa atgtgggaaa atgaaggtga aaaagtttta tatgttaaat
     1321 cattaaaaat agatgaatct aagaaaggag aaataaaaat tagaccaaaa tcattaaaag
     1381 agagatatga agaattgttt gatatagagg acctaaaact agaaaagaat caacaaaaag
     1441 tactggaaaa tctatttaaa gctattgatg ttaaaaattt tggtgcaaca tttgcagaag
     1501 aaggaaataa tataggaatt atgggcgcag tacaaattgg acaaggattt aataagtatg
     1561 aagatattaa tgttgaagaa caacaaatat tatccccatt tagggatcca aaagcaaaag
     1621 ataagaaaaa gtcaacaaat gaagaagaaa aagaagatgc aaattcaact acattaggaa
     1681 aaaaaatagt aagtgatgag gctcattact tttatccatt ttcaataaat ccaaaagctt
     1741 atgaagtttt tgttaatatg ggtgtgactg atggatatac taaaaatgat tataaaaaat
     1801 ttaaagaagc tgctttagta agtgcaactg cattcaatac aaattcaaag cttggttgcg
     1861 aaaatgaatt tgcattattt gttgaaactg atgaagagtt atacctacca gatttggcac
     1921 aatatataac ttttgaaaag agagaaaaat caaaagattt aatttgtata aatataattc
     1981 atcttatagc agaattaaaa gatgatataa agagcgttga gatatattat aacccatata
     2041 aaatagaaat aaagcctttt aaagatgaaa tattacctaa gatagataaa gttaaattta
     2101 tgaacatatt tacaagaaaa gaggtataat atggaggttt tgaaatttaa cttaagtgga
     2161 aaaactgctt tttttaaaaa accagatgta aatagcataa tttattttac gtatggaaac
     2221 atacataaaa ttgcacttat gggtatttta ggagcttgtt taggacttgg tggatataat
     2281 caacagagta aggaagatga gtatccagaa ttctactctt tacttaagga tataaaaatg
     2341 tcaatagttc caaagcatga atttggatat ataaataaaa aagtccatat atttaataat
     2401 tctgtaggat atgcatcaaa agaagaaggt ggaaatttaa taataaaaga acagtggctt
     2461 gaaaatgtta gttgggatat atatatacaa ttagaagatt caactacaag tagagagctt
     2521 aaaagaagat ttttatctaa taaatttgta tatatacctt acttaggcaa aaacgatcat
     2581 atagctaata taagtgaaat agagataatt actgattttt acaaaacaga agatattaac
     2641 agagtggaca gtttctttat aagagaggat tttgagtttg aaaaatctta ttttgatgat
     2701 aatgatgatt ataaagagcc atttaaatat caggaaaaac ttccttatag actgcaccga
     2761 atgactaatc aatatatttt ggaaactatc atatttacta atatgtcagt taaattgatt
     2821 aataaaaaag aggtatatca agtaaagggt ttaaatttaa tctttattta aatttatagg
     2881 tttaggagaa ttatatgtac tttaaaaaag ttgagttgtt tgatataagt aataatataa
     2941 ataattgcaa aaatatttat gctcatataa ataaagacag gaagccagaa actttaaaag
     3001 aacattcaga cttatcatac tcatatctta tgaaattatg tgtaaaaaaa gatttaagct
     3061 cttgcctaga gagaatagag aataaatttt ttaaaaaaga ttctttttta agtaagaatt
     3121 tttatagaga gattatcttg aatatggttt atatgcatga tataggtaag attaattctt
     3181 catttcagtt tgtaaaaatg caaaataaaa attttaaaaa aatttcactt agatatacta
     3241 aacattcttt tatctcttca atgctatatt ttgattacta ttttgaaaag cttaaaaaat
     3301 atgattttga agaaaaaaaa atattgagtt tatttttgat gataaataca tatacaatat
     3361 caaaacatca tggggttctg aagtcattta aagaattttt atttttattt aaagatgagt
     3421 ttataaacat taaagaaaat tttaaagatt tatttaaaaa caattataat ttagagctta
     3481 aatcagttcc caaaactata gaaaaaatgg taagaggtgt agaagcgtat ttagatgata
     3541 gccatataaa ggataactta gctatagact tatatatata ttcaaaattg atgttttcaa
     3601 ttgttacatc ttgtgatttt tatgctacat cagaatataa tagtggtaat tctatagatg
     3661 attttgggac aattgataat tataataagt attatgatgt attaaaaaaa tctgaaatat
     3721 ataaggggat gaaaaaatat agggaatact taaataacaa tagtgaatgc ccatataaag
     3781 agaatgatat aaacagattg agaacagaaa tgagtataga agctgaagat gcaattacac
     3841 ataatacgag aaaaagaata ttttatttag aagcaccaac tggaagtgga aaaactgtta
     3901 catctataaa tctagcactg aaatctatag agttaaatca atctttaaaa aagatatttt
     3961 atatatttcc atttaacaca ttagtagagc aaacaaaaga tgtatttata aatgaaatat
     4021 ttaattctgt taaagacata caaaaagatg ttgtagttat aaattcaata acaccaatac
     4081 aaacagaaga taaagaagaa gataataaaa atgttgaata ttgtgttact aaacaagaaa
     4141 ttgattatga taaatcattg ttaaatagac aatttttaca ctatcctata gtacttacaa
     4201 ctaatatagg tttttttaac tatttgtttg gtgtatcaag agaagaatgt tttccattga
     4261 tac
//
LOCUS       DAEHWM010000170         4184 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.173, whole genome shotgun sequence.
ACCESSION   DAEHWM010000170 DAEHWM010000000
VERSION     DAEHWM010000170.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4184)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4184)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4184
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.173"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            685..1941
                     /locus_tag="KNP36_003631"
     CDS             685..1941
                     /locus_tag="KNP36_003631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HBF0875457.1"
                     /translation="MIEKFKTLIWIKMIIRIKSVYKTYGGLFFLGLIGIPVGAIIGLI
                     DTIFGTVLLKVTDIRETYPMYLIPFLAVVGVVIAYCYFKFGGKSSKGMNLIFEVGHGE
                     EEIIPLRLVPFIISGTWLTHLFGGSAGREGVAVQIGATFSHWVGKRLPIKNACSIFLV
                     TGMAAGFAGLFETPIAAILFAMEVLVAGSLEYQSLFPAFTASFTASSVSKALGLEKFS
                     FALSSKVVFDLSIFWKLIVLGIIFGMVGGAFAWCLKLSKRKIGNRLKNPMIRIAIIGV
                     CLSVLFLLFYKGRYSGLGTNLIQNSFYGGEIYSFDWLLKFILTILTLSAGFQGGEVTP
                     LFSIGASLGVLLAGFFNLPIELVAALGYASVFGSATNTFFAPVFIGAEVFGYSYLPYF
                     FVVCAISYIFNMDKSIYSLQKISTKQ"
     gene            2004..3197
                     /locus_tag="KNP36_003632"
     CDS             2004..3197
                     /locus_tag="KNP36_003632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HBF0875458.1"
                     /translation="MLTSLALIFLLGMASGGIFKRIKLPNLLGMLLTGIILGPYVLNL
                     IDNSILDISSDLRKIALIIILTRAGLSLDINDLKKVGRPAVLMCFIPATFEIIGMIVL
                     APKLLGVSILEAAVMGAVVGAVSPAIIVPKMLKLMEEGYGTEKSIPQMLLAGTSIDDI
                     FVIVMFTVFTGLAQGNSISAISFLQIPVSIILGVIVGAVIGICLAVFFKKVHMRDSAK
                     GVLLLSISFLMISLETALEGIVPFSGLLAVMSIGIFLQIKYRVVARRLSIKYSKLWVG
                     AEILLFVLVGATVDISYAFKAGIGAVILIFGVLLFRMVGVFFCLIKTNLTIKERLFCM
                     IGYIPKATVQAAIGGVPLAMGMASGQLILTLAVLAILITAPLGAFGIDVTYKKLLTSV
                     KGESK"
     gene            3398..3778
                     /locus_tag="KNP36_003633"
     CDS             3398..3778
                     /locus_tag="KNP36_003633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875459.1"
                     /translation="MCLKKLSKLELVIMKFIWNLDIKTNSYEIIDYMKEEHNLPEKVA
                     LKTLSKLSKKRFLYVQETGKCMYYTVAIKEKAYLEFISRNVQNLLKNNFIRNLLVSFH
                     EEELTEEKIKSLENWVVNWEEAYV"
BASE COUNT         1486 a          429 c          753 g         1516 t
ORIGIN      
        1 tttaaatcat gtatcataat gcagagtgaa gaaaatattt aaatcatgta tcataatata
       61 agcagagtga agaaaatatt taaatcatgt atcataatat aagcagagtg aagaaaaata
      121 tttaaataat atatcataat gtggagtgag gaaaaatatt taagttatgt atcataatgc
      181 aaagtaaaga aaatcattta aattatatat cataaaaata atatgaaata ttgaacactc
      241 ataatattag aggctttact attttaattg ataggttata ttatttataa cattaaaaat
      301 acaatttaca taaaatagac atatgaaaaa taaaaaatta tataataatt atgggaatga
      361 ggttctccct tggatgataa tatcctaaac tgccaatgag ctgatgactt ctatgatatc
      421 atagatgcca ccagcttttt ttgttgttta aatcaataaa atggaggtga agtacttact
      481 aaatttttat tttttaaatt tgaagaaata tttaattaat agaaaaaata gtagattata
      541 tgttaattat tttattaaga atgggttaag agtgtaccta tatcctatca atttaaaaaa
      601 caattatgat agtcattaca ttgactacag ttgatgtaat aaaactttca aaaaatctta
      661 tgatgcaaat agaaaggaat taaaatgata gaaaaattta aaactttaat atggattaaa
      721 atgataataa gaattaaaag cgtttataaa acatatggtg gactattttt tttaggactc
      781 ataggtatac cagttggtgc aattataggt cttatagaca ccatatttgg aacggttctt
      841 ctaaaagtta cagatattcg agaaacatat ccaatgtatc tgataccatt tttagcagta
      901 gtaggagttg ttattgctta ttgctatttt aaatttggag gaaaaagtag taaaggaatg
      961 aatctaatat ttgaggtagg gcatggagaa gaagaaatta ttcctttaag attggttcca
     1021 tttataatat caggtacatg gttaacccat ttatttggtg gtagtgcagg acgagaagga
     1081 gttgctgttc agattggtgc aactttttca cattgggtag gtaaaaggtt gcctataaaa
     1141 aatgcttgta gtatttttct agtaactggt atggcagctg gttttgcagg attatttgag
     1201 acaccaatag cagcaatact atttgctatg gaggttttgg tagctggttc actggagtat
     1261 caatcgcttt ttcctgcgtt tactgcttct tttacagcaa gttcagtatc aaaagcttta
     1321 gggttagaga aattttcttt tgcactttct tctaaagttg tatttgactt gtcaatattt
     1381 tggaagctta ttgttttagg aattattttt ggaatggttg gtggagcatt tgcatggtgt
     1441 ctgaaattgt caaaaagaaa aataggtaat agattaaaaa atcctatgat aagaattgct
     1501 attattggag tatgtcttag tgtattattc cttttatttt ataaaggaag atattcaggt
     1561 ttagggacaa atttaattca aaatagtttc tatggtggag aaatttattc atttgattgg
     1621 ctgttaaagt ttatacttac aatactgact ttgtcagcag gttttcaagg aggagaggtt
     1681 acacctttgt tttccattgg agctagtctt ggtgtattgt tagcaggatt ttttaatttg
     1741 ccaattgaat tagttgcagc gcttggctat gctagtgtct ttggtagtgc tacaaatact
     1801 ttttttgcac ctgtatttat aggggcagaa gtttttggat acagctattt accttatttc
     1861 tttgtagtat gcgctatttc atatatattt aatatggata aatctattta ttcactacaa
     1921 aaaatttcaa caaaacaata aataaaacaa cataatgtat gattagaaga gaaagaatat
     1981 tagagaaagg atagggtagg aatatgttga caagtttagc tttgattttt ttattaggaa
     2041 tggcctcggg aggtattttt aagaggataa agttacctaa cttattggga atgttactta
     2101 caggaattat attaggtcca tatgttttaa atttgattga taattcaata ctagatattt
     2161 cttctgacct tagaaagatt gcattgatta ttatattaac aagggctgga ttatctttag
     2221 atataaacga tttgaagaaa gtgggaagac ctgctgtact tatgtgcttt attccagcta
     2281 cttttgaaat tatcggaatg atagttttag caccaaaatt actaggcgtt tctatattgg
     2341 aagcagcagt catgggtgca gtagtaggag cagtttctcc cgcaattatt gtacctaaaa
     2401 tgcttaaatt aatggaagaa ggttatggta cagaaaaaag tattccacag atgcttttag
     2461 caggaacttc tatagacgat attttcgtaa ttgtgatgtt tacagtattc acaggattgg
     2521 cacaaggaaa tagtatatca gctattagtt ttttacaaat tccagtatca attatattag
     2581 gtgtaatagt tggagcagtg attggaatct gtttagcagt attttttaag aaggttcata
     2641 tgagagattc tgctaaaggg gtgttgcttt taagtatctc atttttaatg ataagtttag
     2701 agactgcttt agagggtatt gtgccatttt ctggattatt agcagttatg agtattggga
     2761 ttttccttca gataaaatat cgtgtagttg caagaagatt gtccataaag tattcaaaac
     2821 tatgggttgg cgctgaaatt ctcttgtttg ttttggtagg ggcaacagta gatataagtt
     2881 atgcatttaa agcaggaatt ggagctgtaa ttttaatatt tggagttctt ttattccgta
     2941 tggtaggagt attcttctgc cttattaaga caaatttgac aataaaggaa aggttgttct
     3001 gtatgattgg ctatattcca aaggctacag tacaggcagc aataggaggt gtaccacttg
     3061 caatggggat ggcatctgga caacttattt tgacgttagc agttctagct atacttataa
     3121 ctgcacctct tggagctttt ggaattgatg taacttataa aaaattatta acttctgtaa
     3181 aaggcgagag taagtaaaaa taaagattat tttaactggt aagttatatt ttggaaaagg
     3241 attatactat tgaatacaat ataaaaaaat catttgggag attaagaagg tagaagttaa
     3301 gaacagattt taaggtatgt tatgattatt agaattgatt ttgtgaaatt attattgtaa
     3361 tatttaatta tatagataaa gaagcggagt gataactatg tgtttaaaaa aattatcaaa
     3421 attagagtta gttattatga aatttatttg gaatttagat ataaaaacca attcatatga
     3481 gattattgat tatatgaaag aagaacataa tttaccagaa aaagtagctt taaaaacttt
     3541 atcaaaacta tcaaagaaaa gattcttata tgttcaagaa acaggcaagt gtatgtatta
     3601 tacagttgca ataaaagaaa aggcatattt agagtttata tcaagaaatg tgcaaaatct
     3661 tttgaagaat aattttataa ggaatttatt agtatcattt cacgaagagg agctaacaga
     3721 ggaaaagata aagtcgttag aaaactgggt agtaaattgg gaagaagctt atgtataaat
     3781 gttattattt ttattacaat ttagataatt ttggttttgt aagctctgca actattttta
     3841 gatggttgca gagtttattt ttatttttta ttcccttaag caatacttaa aagtaaacgc
     3901 atttatattt actaacttca attacttcta atacttaaat tactttttaa aaatattttg
     3961 atatgtcatc tctatagtaa tctagaactt gtttctattc tttatataaa gtttttatga
     4021 atgatatata taatattcgt tcatttgatt aaaaataaca aaatattaaa taattctact
     4081 ctgatagttt gttaaaaaaa taataaaaaa tattaataaa caaaaaaaaa attatcttaa
     4141 gagaggagaa tgttctaaaa tataaaaagg tttctagatt tcat
//
LOCUS       DAEHWM010000171         4126 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.174, whole genome shotgun sequence.
ACCESSION   DAEHWM010000171 DAEHWM010000000
VERSION     DAEHWM010000171.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4126)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4126)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4126
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.174"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            456..1349
                     /locus_tag="KNP36_003634"
     CDS             456..1349
                     /locus_tag="KNP36_003634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfide/dihydroorotate dehydrogenase-like
                     FAD/NAD-binding protein"
                     /protein_id="HBF0875460.1"
                     /translation="MSNKIVSKRQLTDSIYLMEIEAPRVAKSSQPGQFIIIKNDEKGE
                     RIPLTIADYDREKGTVTIVFQTVGASTKKLAMFEENDFVMDFVGPLGQASEFIHEDIE
                     ELRNKKILFVAGGVGSAPVYPQVKWFKEHGLDVDVIIGARTKELIILEDDMKKVAKNV
                     YVSTDDGTYGFNGRVTDLLKDLVDNQGKKYDQAIVIGPMIMMKFMCQLTKELNIPTIV
                     SLNTIMIDGTGMCGGCRVSVGNETKFACVDGPEFDGHLVDFDQAMRRQSMYKTQEGRA
                     MLKLEEGDSHHHSNCGCGGNK"
     gene            1349..2743
                     /gene="gltA"
                     /locus_tag="KNP36_003635"
     CDS             1349..2743
                     /gene="gltA"
                     /locus_tag="KNP36_003635"
                     /EC_number="1.4.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent glutamate synthase"
                     /protein_id="HBF0875461.1"
                     /translation="MDAKKVKVPVREQEPAVRATNFDEVCLGYNKEEAMAEANRCLAC
                     KKPKCVGGCPVGIDIPGFITKIKEDDIEGAAKVIAKSSSLPAVCGRVCPQESQCEGVC
                     ILGIKSDAVSIGKLERFVADWSKENDINLSDTEPKKNQKVAVIGSGPAGLACAGDLAK
                     KGYDVTIFEAMHEPGGVLTYGIPEFRLPKQAVVQPEIDNIRKLGVKIETNVIVGKTIT
                     VDELIEDEGFEAIFIGSGAGLPMFMNIPGENANGVFSANEFLTRVNLMKAYRDDYDTP
                     ISSGKKVAVVGGGNVAMDAARTALRLGSESYIVYRRSEKELPARAEEVHHAKEEGIIF
                     NTLTNPKEILVDENGYVKGMVCIRMELGEPDDSGRRRPIEIEGSEFVLDVDTVIMSLG
                     TSPNPLISSTTKSLDINKKRCLITDENGQTSKEGVFAGGDAVTGAATVISAMGAGKTA
                     AASIDEYLKAKVNA"
     gene            3109..>4126
                     /locus_tag="KNP36_003636"
     CDS             3109..>4126
                     /locus_tag="KNP36_003636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cache domain-containing protein"
                     /protein_id="HBF0875462.1"
                     /translation="MKKREKVFDGLVFKHILILLILLVLIDLTSTIIYASNSMEITSR
                     NMIEASKRELENYLEVNISLLKALSQDDRFSNGETSLIEKGKLLSPYQKEYNLFMIGI
                     TDTKGNASSTYRENVNSIKDKPSFEKAIKTKQVVVSDIEVSNVTGDKVFIIYVPIVKN
                     NEMIGTIFASFYFQDVNNLISRSNFDDSIKFLMIDKDYTIISHPNKKYVNDKSKMLDL
                     EGNIIGTTKSEILKNINKKCQGDFLSWDNWRLYNVKYTNIKWTNWTLVSKCNIFKNFK
                     NLIVNFMIKLYFYIVIFMILWKLSNAKLIEQLKKLAYYDSLSGIKNKEKFRKDSMYIL
                     KNYYQ"
BASE COUNT         1639 a          403 c          780 g         1304 t
ORIGIN      
        1 aataaaataa gagtatattt tatacaatat gaaagctggt attgcaatag attaaagcct
       61 tatacacgtt tagtttttaa agaaattagt gttattatga aaacctaagt taatttatta
      121 aataaataat tgaataaaaa aattttatta tgtatttata aaatttttgt tacaaatttg
      181 gcataatata gtatacttta agtgtgtatt aggttaaatc tataacaaat tagacgtatg
      241 atatagactt agtgtttatt ggcatttaca agaaatttgt taatatcaac tatttgtagt
      301 ttgggcagtt ataattatta taggggggat gtccaataca aaacaatcaa ccaagaacta
      361 atattatatt ataaagagtt atagttttgt gtgtttatgt ttttaattaa atttaaagtg
      421 ggaaaaatat atttgttaga atggagaata gcgagatgag taataaaata gttagtaaga
      481 gacaattaac agatagtatt tatttaatgg aaatagaggc acctagagtt gcaaaatctt
      541 ctcaaccagg tcaatttata ataattaaaa atgatgaaaa aggagagagg attcctctta
      601 caatagctga ctatgataga gaaaaaggaa cagtaactat tgtattccaa acagttggtg
      661 cttcaactaa aaagttagca atgtttgaag aaaacgattt tgtaatggat tttgtagggc
      721 cattaggaca agcaagtgaa tttatacatg aagatataga agaattaaga aataaaaaga
      781 tattatttgt agctggtgga gttggttctg ctccagttta tccacaagtt aaatggttta
      841 aagagcatgg attagatgta gatgtaataa ttggtgcaag aactaaagaa ttaattatat
      901 tagaagatga tatgaaaaaa gtagctaaaa atgtatatgt atcaacagat gatggtacat
      961 atggatttaa tggaagagtt acagacctat taaaagattt agttgataat caaggtaaaa
     1021 aatacgacca agcaatagta attggaccaa tgataatgat gaaatttatg tgccaattaa
     1081 ctaaagaact aaatatacct actatagtaa gtttaaatac aataatgata gatggaacag
     1141 gtatgtgtgg tggttgtaga gttagtgttg gaaatgaaac taagtttgca tgtgtagatg
     1201 gtcctgaatt tgatggtcat ttagttgatt ttgatcaagc aatgagaaga cagtctatgt
     1261 acaagactca agagggaaga gctatgctaa aacttgaaga aggcgatagt catcatcata
     1321 gtaattgtgg atgtggaggt aacaaataat ggatgctaaa aaagtaaaag taccagttag
     1381 agaacaagaa cctgctgtga gagcaacaaa ttttgatgaa gtatgcttag ggtataataa
     1441 agaagaagct atggcagaag ctaatagatg tttagcttgt aaaaaaccaa aatgtgtggg
     1501 tggatgtcca gtaggaatcg acataccagg gtttataaca aaaattaaag aagatgatat
     1561 agaaggtgct gctaaagtaa tagctaagag cagttcatta ccagctgttt gtggtagagt
     1621 atgcccacaa gaaagtcaat gtgaaggtgt atgtatactt ggaataaaat cagatgctgt
     1681 atcaataggt aaattagaaa gatttgtagc agattggtca aaagaaaatg acataaattt
     1741 atctgataca gagcctaaga aaaatcaaaa agtagcagta ataggaagtg gtccagcggg
     1801 tctagcttgt gctggtgatt tagctaaaaa aggctatgat gtaacaatct ttgaagcaat
     1861 gcatgagcca ggtggagttt taacttacgg aatacctgag tttagacttc caaaacaagc
     1921 tgttgttcaa cctgaaatag acaatataag aaaattaggt gtaaaaatag aaactaatgt
     1981 aattgttggt aaaacaatta cagtagatga acttatagaa gatgaaggat ttgaagctat
     2041 attcataggt tcaggagctg gtcttccaat gtttatgaat ataccagggg aaaatgcaaa
     2101 tggagtattt tctgcaaatg agtttttaac tagagtaaac ttaatgaagg cttatagaga
     2161 tgattatgat acacctatta gttctggtaa aaaagttgct gtagtaggtg gtggaaatgt
     2221 tgctatggac gctgctagaa ctgcattaag attaggttca gaatcatata tagtttatag
     2281 aagaagtgaa aaagagcttc cagcaagagc tgaagaagtt catcatgcaa aagaagaagg
     2341 cattatattt aatacattaa caaatcctaa ggaaatttta gtagatgaaa atggatatgt
     2401 taaaggtatg gtttgtataa gaatggaatt aggagagcca gatgattctg gaagaagaag
     2461 acctatagaa atagaaggtt ctgaatttgt acttgatgta gacacagtta taatgtcact
     2521 tggaacaagc ccaaatccac taatatcttc tacaacaaag agtcttgata taaataagaa
     2581 gagatgctta ataacagatg aaaatggtca gacttctaaa gagggtgtat ttgcaggtgg
     2641 agatgctgtt actggagcag caacagtaat atctgcaatg ggtgctggta aaacagcagc
     2701 agcatcaata gatgaatatt taaaagcaaa agttaatgct taatttgtaa attaaagaga
     2761 gggtgtctca aaatgaactt tttagttcat gaggcactct ttttgtacaa aatcaaatat
     2821 gttttaatca tttcaacaat gaaaatttca ttcctgtaga aagtctaact tttaggtctt
     2881 agtacaatct ctattttgat gtagccactt ttttagatgg tttaataatt tatcagttat
     2941 tattgtaata tttgatacta agtaacataa ctttgtctaa ctatgataaa atagttatac
     3001 aataaaggtc ttgtaaggag tgaataatgt gtggctaata aaatcagatt tgtcaaatct
     3061 aacattaaat aatagaaaaa taaattgtgt aattaatggt attttaatat gaaaaaaaga
     3121 gaaaaagtat ttgatgggct agtttttaag catatattaa tcttattaat actattagtt
     3181 ttgattgatt taacaagtac catcatatat gcaagtaact ctatggaaat tacttctaga
     3241 aatatgattg aggcatcaaa aagagaactt gaaaactatt tagaagtaaa catatcttta
     3301 ttaaaagctc ttagtcaaga tgatagattt tctaatggtg aaacatcact aattgaaaag
     3361 ggaaaattat taagtccata tcaaaaggaa tataatcttt ttatgattgg tataacagat
     3421 acaaaaggaa atgcttcaag tacatatagg gaaaatgtta actcaataaa agataagcct
     3481 agttttgaga aagcaattaa aacaaagcaa gtagtagttt cagatattga agtcagtaat
     3541 gtaacaggtg acaaagtatt tatcatatat gtaccaattg taaaaaataa tgagatgatt
     3601 gggaccattt ttgcttcttt ttattttcaa gatgtaaata atttaataag tagaagcaat
     3661 tttgatgatt ctattaaatt tctaatgata gataaagatt atactattat ttctcatcca
     3721 aacaaaaaat atgtaaatga taaaagtaag atgcttgatt tagaagggaa tattatagga
     3781 accactaaaa gtgaaatctt aaaaaatata aataaaaaat gtcaaggtga ttttttatct
     3841 tgggataatt ggagattata taatgtaaaa tatacgaaca taaagtggac taattggact
     3901 ttagtatcaa aatgtaatat atttaagaac tttaaaaatc taatagttaa ttttatgata
     3961 aagttgtatt tttatatagt aatatttatg atattgtgga aattaagtaa tgctaaatta
     4021 atagaacaac ttaaaaaatt ggcttattat gattctttaa gtggaataaa aaataaagaa
     4081 aagtttagaa aagattctat gtatatttta aagaattatt atcaag
//
LOCUS       DAEHWM010000172         4118 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.175, whole genome shotgun sequence.
ACCESSION   DAEHWM010000172 DAEHWM010000000
VERSION     DAEHWM010000172.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4118)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4118)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4118
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.175"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            174..926
                     /locus_tag="KNP36_003637"
     CDS             174..926
                     /locus_tag="KNP36_003637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrmB family transcriptional regulator"
                     /protein_id="HBF0875463.1"
                     /translation="MDNIINELQNIGFTKYESQIYISLLKESPLTGYEISKLSGVPQS
                     KVYENITKLLNNNIIINVGTDPIKYIPINPNELLKNKKKEFDNSMDNLKNSLQILNKS
                     KSVEYVLNIKGDKNILKKAIEMIKNAKQEIIISCPYEEILELKKELLIAYKKNINIEI
                     LLLENKSLKGLDNIHIHGGNKTTLENKMLYKGIILIVDNDEILTGNLSEGSEAISIWT
                     KNSNILYIGVQYIKHEIYISEQIKGGYKNEQN"
     gene            913..1794
                     /locus_tag="KNP36_003638"
     CDS             913..1794
                     /locus_tag="KNP36_003638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003432046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="HBF0875464.1"
                     /translation="MNKIKIKQVDAFTTIPFGGNPAGVVTDTSNISDEIKQNVAKEMN
                     LSETAFVSESNIADFKVQFFTPGLEVDLCGHATIGTFHALLEEGKLNTNKSIFYQETK
                     AGVLSVELKKINNENIFMMEQNTPEFENLDNCRKELAQMIGVHEDRLLEYPIIKVNTG
                     LWWLVFGLKSLDDLKNISPDLNKIKKFSGDNNIIGITPFCIETIDKKCDYHLRSIAPY
                     VGVTEDPVCGTGNACVSSYIVHHNILDKTSFIGEQGNFINRPGKVYVNITRENNNITS
                     VKIGGSAYTVLSGEIMY"
     gene            complement(2020..3375)
                     /locus_tag="KNP36_003639"
     CDS             complement(2020..3375)
                     /locus_tag="KNP36_003639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBF0875465.1"
                     /translation="MSSTVKKKGKFPMGFYICSTTFSFERAAYYASKYLIYIFLTTAI
                     VHGGLGIDKGQAAIMQANLVAFTYLAPIIGGYISDRWIGARYTIPIGMLIMGVGYYLG
                     SIATTVSMVNAMIILVSIGTAFFKGNVSAVNGQLFDSQEELDTAFSVQYSFVNIGSFI
                     GTIAVGILYLKTFAKNGVLGFSQCFFIAAVLCVIGAIWFIYGWRFLGNAGKRPFKEGV
                     VAEKIEEKDKSPLTSMDKKRIWAIILISFFSVIFWVFWYLTYLAVYDYGAAFVNMNVG
                     GFDVPLAWFDSLNSLVCIVLGPVLGALWFKLASRPQGDMSLFKKTGLGLIFLGLAFLM
                     LVGAEFSRGVGAPETAKASILWIIMFGILLSLGEMLFSPLGNSFVSKYAPKKLLGVLM
                     GVWTFATFIAGKGYGYIYAFTLKFDMIKVYTIIPVILFVAAILLFLSDKTLSRLVEDD
                     K"
BASE COUNT         1610 a          602 c          511 g         1395 t
ORIGIN      
        1 atagatttaa tattatgata aatagattta taagattaaa tatttataag actaaatatt
       61 tctaatatat tttatttttt tcttaatata gttgacattt tttcccttaa attataaaat
      121 caaattaata actacatagg tagttactaa tcttttatca aaggagtttc tatatggata
      181 atattattaa tgaattacaa aatataggat ttactaaata cgaatctcaa atatacatat
      241 cattattaaa ggaaagccct ttaacaggat atgaaataag taaattatca ggtgtaccac
      301 aatcaaaagt ctatgaaaat ataacaaagc tattaaacaa taatataatt atcaatgttg
      361 gaactgaccc tattaagtac ataccaataa accctaatga attattaaaa aataagaaaa
      421 aagaatttga caattctatg gataatctaa agaatagctt acagatatta aataaaagta
      481 aaagtgtaga atacgtatta aacataaaag gagataaaaa tatattaaaa aaagcaatag
      541 aaatgataaa aaatgcaaaa caagaaatta taatttcttg cccttatgaa gaaattcttg
      601 aattaaaaaa agaactccta attgcttaca aaaaaaatat taatattgaa atactacttt
      661 tagaaaacaa aagtctgaaa ggtcttgata atattcatat tcatggaggt aataaaacta
      721 cacttgaaaa taaaatgctt tacaaaggaa ttattttgat tgtagataat gatgaaatat
      781 tgacaggaaa cttatcagaa ggcagtgagg ccatttcaat ttggacaaaa aactctaaca
      841 ttttatatat tggagttcaa tacataaaac atgaaattta tatttcagaa caaataaaag
      901 gaggttataa aaatgaacaa aattaagatt aaacaagttg atgcttttac aactatacct
      961 tttggtggaa atcctgctgg tgtcgttact gatacctcta acatttctga tgaaattaag
     1021 cagaatgtgg ctaaagaaat gaatttatca gaaactgcat ttgtttcaga gtcaaatatt
     1081 gcagatttta aagtacaatt tttcacacca ggtttagaag ttgatttatg tggtcatgca
     1141 acaataggta ctttccatgc acttttggaa gaagggaagc ttaatactaa taaaagtata
     1201 ttttatcaag aaacaaaagc tggtgtatta tctgtagagc ttaagaaaat aaataatgaa
     1261 aatatattta tgatggaaca gaatacacct gaatttgaaa atttagataa ttgcagaaaa
     1321 gaacttgcac aaatgatagg tgtgcatgaa gatagacttc ttgaatatcc tattataaag
     1381 gtaaatactg gactttggtg gcttgtattt ggtctaaaat ctttagatga tttaaaaaat
     1441 atctctccag atttaaataa aatcaaaaaa tttagtggtg ataataatat aattggtata
     1501 actccatttt gtatagaaac tatagataaa aagtgtgact accatttaag atctatagca
     1561 ccatatgttg gagttacaga agaccctgta tgtggaactg ggaacgcttg cgtatcatct
     1621 tatatagtac atcacaatat tttagataaa actagtttta ttggtgagca aggtaacttt
     1681 ataaacagac ctggaaaggt atatgtaaat ataactagag aaaacaataa cataacttct
     1741 gtaaaaattg gaggaagtgc ttatactgtc ttaagtggtg aaattatgta ttaatcccat
     1801 acctaataaa aacaaataaa aatactagct aactaaagct agtattttta tttgttattt
     1861 ttatttaata atcatactct aacaaatatt ataattatat atatcataat attgtattta
     1921 gaagtaaaat tttattttta ttattaatta gttataaatc aatctaatac aacataatta
     1981 cagtagatta acctataaaa cataataatt gcttactgat tatttatcgt cctcaacaag
     2041 tctacttaat gtcttatcag ataagaataa taatatcgct gcaacaaata gtattactgg
     2101 aattatagta tatactttaa tcatatcaaa tttaagagta aatgcatata tatatccata
     2161 tcctttacca gctataaaag tagcaaatgt ccatactccc ataagaacac ctagaagctt
     2221 cttaggtgca tacttactta caaaagagtt accaagtggt gagaataaca tttcaccaag
     2281 acttaaaaga ataccaaaca tgattatcca tagtatacta gctttagcag tttcaggagc
     2341 tccaactcct cttgaaaatt ctgcaccaac aagcattaag aatgcaagac ctaagaatat
     2401 taatccaaga cctgtctttt taaataaact catatctcct tgtggtctac tagcaagttt
     2461 aaaccataat gctccaagaa ctggtcctaa tactatacat acaagtgaat ttaatgagtc
     2521 aaaccaagca agaggaacat caaatcctcc aacattcatg tttacaaatg ctgcaccata
     2581 atcataaact gcaagataag ttagatacca gaatacccag aaaattacag agaagaatga
     2641 tataagtata atagcccaaa ttctcttctt atccatgctt gtaagaggag acttatcttt
     2701 ttcttcaatt ttttcagcaa ctacaccttc tttaaaaggt ctctttcctg cattcccaag
     2761 gaatctccat ccatatatga accatattgc acctattaca caaagtacag ctgctataaa
     2821 gaaacattga gaaaatccaa gtacaccatt ttttgcaaat gttttaaggt aaagaatacc
     2881 aactgctata gtaccaataa aagaacctat attaacaaaa gaatattgta ctgaaaatgc
     2941 tgtatcaagt tcttcttgac tatcaaaaag ctgtccattt accgcagata cgttaccttt
     3001 aaagaatgca gtaccaattg aaactaagat tatcattgca tttaccatag aaactgtagt
     3061 tgcaatagaa ccaagatagt atcctacccc catgataagc atacctatag gtatagtata
     3121 tctagctcct atccatctat ctgatatata ccccccaatt ataggtgcaa ggtatgtgaa
     3181 tgcaacaagg ttggcttgca ttatagcagc ttgtccttta tctattccaa gaccaccatg
     3241 aactatagct gttgtaagga atatatatat taagtacttt gaagcataat atgctgctct
     3301 ttcaaatgag aaagttgttg agcagatata aaatcccata ggaaatttac ccttcttttt
     3361 tactgttgag ctcataattt taaatccttt cttaattgta tttttatttt ttacgttttg
     3421 tccaaattct ttcttttatg aaagatataa tattattatt ttgtaaaaca atttgtaatt
     3481 attattaaga taattgcgca tttatttgta gagtacatat tctcatggaa taaaattaat
     3541 acacttctta atcataaatt taaattatat aaattcacta ttttcagata tagttataaa
     3601 ttaatatatt ctcatctaat accatgaaaa aaccttcgcc atatgcaatt cttatttttt
     3661 acgtgatagt attttacaaa ctaaaatccc ccttttgtag caacttatgt aattacattt
     3721 tagtgctttt ttaaaggagt ctcgaataaa gcaacatata ttttgttcaa ataatgtttt
     3781 tatttatttt ttaaatttat atattacttc acccaaccaa ttctcaactt aaataactaa
     3841 actactatct attcacagat taggcttatt tcttacacat tagtttataa taaacactgt
     3901 gaatctaaac ataaaaactg ttattttaaa gtaattaccc atatattcgc tttgatacta
     3961 tttattgagg ctatactctt tatgtataat atattattta taaaatacct caaaatatat
     4021 tattcataaa atacctcaaa ctgaaaactt tttcacgaat atttattttt cacctcccct
     4081 tttttatttc accatgtaaa tcgtaccata aatatgca
//
LOCUS       DAEHWM010000173         4071 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.176, whole genome shotgun sequence.
ACCESSION   DAEHWM010000173 DAEHWM010000000
VERSION     DAEHWM010000173.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4071)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4071)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4071
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.176"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            156..1028
                     /locus_tag="KNP36_003640"
     CDS             156..1028
                     /locus_tag="KNP36_003640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875466.1"
                     /translation="MEMKIAVSNLSKRFGKKQALDNINLEIDSGMFGLLGRNGAGKTT
                     FMRILATLLSKTEGSIHMCGVPIENTKEIRNMVGYLPQDFSMYPNMTVYKAMDYLAVL
                     SDIPLRKRRKIIAKLLSKVNLTNYQNVKVKSLSGGMNRRLGIAQALIHNPRVLIVDEP
                     TAGLDPEERIRFRNLLCEIANDRIVILSTHIVGDIEATCENVAILNSGKVIYNGSTEA
                     LAKLAEGKVYSIEVDKKDIENIKSRFIVIGMLTHGGKAILRIISDDKPFETAVNCNPT
                     IEDGYMLIMGGDNI"
     gene            1025..2314
                     /locus_tag="KNP36_003641"
     CDS             1025..2314
                     /locus_tag="KNP36_003641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875467.1"
                     /translation="MNLFIKECKNILKSMVYYIFIVVLVFFYISQLGSSVSNDVSKNI
                     PNDGNPLVAPQKVENIEEYYSVHNQYPYGQKESMKTEKVIPNATINLIREYQKNTYTT
                     YPTGVVKYIKLDQNKTKTIEKYIEEITGKSISEINSLWKTDESIKIDYSKVSLERFEE
                     IMQRVDDILGGGSAYAFDKLQRFGVVPVTYDEAMKNYNYTIQKDKVSNGYARIFCDYI
                     GIVLSIFPVFVAVFMSLKDKRSRMREIIYSKQVSSCKIVLSRYFALVFMMILPVLILG
                     MKDLLPLIFFAKDKGISIDNLAFIKYTLWWILPTLMIVTAVGMSITILTDTPVAIIVQ
                     LIWWLYSINSTGLKGDYSTMGLMIRHNSVLNGDIIIQNFNQIMINRIVISLGALVLVL
                     LAIFLYEQKRRGNLDVWAKFSKLFSSNKRKLQIKHFN"
     gene            2244..2888
                     /locus_tag="KNP36_003642"
     CDS             2244..2888
                     /locus_tag="KNP36_003642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875468.1"
                     /translation="MFGQSFQNCLVLIKENFKLSTLTNLICSIILLCMVPLIQGVANL
                     DRISTAICLENYVAIIGIVMLVPVFSLEQSKEIDEIVSSKALSQVIVQLIRILMSIIG
                     IVVLIIGFVNVLIYLGCNFPVVEYIIGSFASAMFIGSLGMFFSNLFNNTIIGYMISIG
                     YLILNMMTKGKYVGKFFIMSMSQGSFDEKYWLILGSVVLIIASLLIKPVKRKIR"
     gene            complement(3155..3619)
                     /locus_tag="KNP36_003643"
     CDS             complement(3155..3619)
                     /locus_tag="KNP36_003643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0875469.1"
                     /translation="MNLNKVKFTEEHAIEVTNWKYEGKYSIYNLPPWEEIKKKNFSLA
                     KEDKRKNFISFINDNKELIGFINLLDEGSSVFFGIGMKPNYCGMGIGKEIIGLGLQEC
                     RNKYSTKPIVLNVRTWNMRAVKCYESQGFKIVETKVQKTHLGDGEFFVMRYQ"
BASE COUNT         1543 a          473 c          611 g         1444 t
ORIGIN      
        1 actttaattt aattaaaaac agaaaaatta aaatctttag aaaaaattta gaaatttata
       61 aataatatct taagttttag aatttattat gaaaatacag taaaaattta taaaaataaa
      121 attctataaa attgtttctg ggggtgtatt tatatatgga aatgaaaata gcagtatcca
      181 atcttagtaa aagatttggg aaaaaacaag ctcttgataa tataaatctt gaaatcgaca
      241 gtggtatgtt tggtctttta ggaagaaatg gagcaggaaa aaccacattt atgagaattt
      301 tagccacttt attatcaaaa acagaaggtt caatacatat gtgtggagtt cctattgaga
      361 atactaagga aattagaaat atggttggtt atttgccaca agatttttca atgtatccta
      421 acatgacagt atataaagca atggattatt tagcagtttt atcggatata ccactaagaa
      481 aaagaagaaa aattatagca aagttattaa gcaaagtaaa ccttactaat tatcaaaatg
      541 tgaaagtaaa atctttatct ggaggtatga atagaaggct tgggatagca caagcattaa
      601 ttcataatcc cagagtttta atagtagatg agccgacagc aggtcttgac ccagaagaac
      661 gtataagatt tagaaattta ctatgcgaaa ttgcaaatga tagaatcgtt attttatcta
      721 cacatattgt tggagatata gaagctacat gtgaaaacgt agctatattg aatagtggaa
      781 aagtcatata caatggctca acagaagcat tagcaaaact agctgaaggg aaagtatata
      841 gtattgaagt agataaaaaa gacattgaaa atataaaaag tagatttata gttataggaa
      901 tgttgactca tggtggaaag gctatactta ggattatatc agatgataaa ccttttgaga
      961 cagcagtaaa ttgtaatcca actattgaag atggctatat gcttataatg ggaggagata
     1021 atatatgaat ctatttataa aagaatgtaa aaatatatta aagagtatgg tatattatat
     1081 ttttattgta gttttagttt ttttctatat ttctcaactt ggaagttcag tttcaaatga
     1141 tgtaagtaaa aatattccta atgatggaaa tccattagtt gctccacaaa aagtagagaa
     1201 tattgaggaa tattattctg tacacaatca atatccatat ggtcaaaaag aatctatgaa
     1261 aacagaaaag gtcattccaa atgcaactat aaacctaatt agagaatatc aaaaaaacac
     1321 atatacaacg tatccaacag gggtagttaa gtatataaaa ttagaccaaa ataaaacgaa
     1381 gaccatagaa aaatatatag aagaaataac tggtaaaagt attagcgaaa taaattcact
     1441 ttggaaaact gatgaaagta taaaaataga ttattctaaa gtatctcttg aaagatttga
     1501 agaaataatg caaagagtag acgacatttt aggaggaggg tctgcatatg cttttgacaa
     1561 gttacaaaga tttggagtag ttccagttac ctatgatgaa gctatgaaga attacaacta
     1621 tacaatacaa aaagataaag ttagtaatgg gtatgcaaga attttttgcg attatatagg
     1681 tatagtttta agtatatttc cagtatttgt ggcagttttt atgtcactta aagataagcg
     1741 ttcaagaatg agagagatta tttattcaaa acaagtatct tcatgcaaaa tagttttatc
     1801 aagatatttt gcacttgtct ttatgatgat attgcctgta ttaattttag gtatgaaaga
     1861 tttacttcct ttgattttct ttgctaaaga taaaggtata tctattgata acttagcatt
     1921 tataaaatat acattatggt ggatactacc aactcttatg atagttacag ctgtaggaat
     1981 gagtattact atattaacag atacaccagt agcaattatt gtgcaattaa tttggtggct
     2041 ttacagtata aattctacag gactcaaagg tgattattca acaatggggc taatgataag
     2101 acataatagt gtattaaatg gggatattat tatacaaaac ttcaatcaaa ttatgattaa
     2161 tagaattgtg ataagcttgg gagcattggt gcttgttttg ttagctatat tcttatatga
     2221 gcaaaaaaga agggggaatc ttgatgtttg ggcaaagttt tcaaaactgt ttagttctaa
     2281 taaaagaaaa cttcaaatta agcactttaa ctaatttaat atgttcaatt atattgctat
     2341 gtatggttcc tctaatacaa ggagtagcta atttagacag aatttcaaca gctatatgtt
     2401 tagaaaatta tgttgcaata atagggatag taatgttggt acctgtattt tcgctagagc
     2461 aatcaaaaga aattgatgag atagtatctt caaaagcatt atctcaagtt attgtacaat
     2521 taattaggat actgatgtca attataggta tagtggtatt aatcataggt tttgtaaatg
     2581 ttttaatata tcttggatgt aattttccag tagttgagta tattattgga agtttcgcat
     2641 cagctatgtt tataggaagt ttaggaatgt ttttctcaaa tttatttaat aatacaatca
     2701 taggttatat gatatctata ggatatttaa ttttaaatat gatgactaaa ggcaagtatg
     2761 ttggaaaatt ttttataatg tctatgagtc aaggtagttt tgatgagaaa tattggctga
     2821 tacttggaag tgttgtgttg ataattgcat ctctcttaat aaaaccagta aaaaggaaga
     2881 ttagataata aaatgagagc ttagataaaa taaaggtaat acaaataaaa agtacattta
     2941 tgaaatataa atctattttt atatacacaa acctacttac aatctcttta tatatgtaga
     3001 tagatttata tatccgtagt ataaaatata tatgtataca aaattttatc aaaagctctc
     3061 aaatttatat ttcaaagaca cttattgcta tgacctacac atatgtattt tttcatttta
     3121 attgttgtat taacaataag actattgtta taaactattg atacctcata acaaaaaatt
     3181 ctccatctcc taaatgcgtt ttttgtacct tagtctcaac tattttaaat ccttgagact
     3241 cataacattt tacagctctc atgttccagg ttcttacatt taatacaatt ggtttagtac
     3301 tatatttatt tctacattct tgtaatccta ggccaattat ttctttacca attcccattc
     3361 cacaataatt cggtttcata ccaataccaa agaatacaga gcttccttca tctaataagt
     3421 ttataaaacc tatcaattct ttattgtcat ttataaaact tataaaattt tttcttttat
     3481 cttcttttgc tagtgaaaaa ttcttctttt taatttcctc ccatggaggt agattgtata
     3541 ttgaatattt accttcatat ttccaattag taacttcaat agcatgttct tcagtaaatt
     3601 taactttatt taaattcata tgtcctccta ttaaaatatt taaggtaatt aatggtattt
     3661 taaagtttta gaaaataagt aaaactattt atatttatcc ataaaatctt taaaaatttt
     3721 actaacaatt cttgtaccct gtacttttta ttggattgac agaagactat aaactaattt
     3781 tgaattacct tctaattcaa aaacatcacg atatatatat aatttcttag cttgattaaa
     3841 ttctgttaaa tccgtttctt atagttgtat aatcaacatc aatatcttta tgtgtattag
     3901 ttaatttatt ggttttagga acttattatt aatatattgt atttgctcca ataatccaag
     3961 tagtaggtaa attataggca aattatcaaa tgtatatcta tccatgctta aactttagag
     4021 atacaataac tactaaatta ctattctagt agttacaaaa aagaatcttt a
//
LOCUS       DAEHWM010000174         4062 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.177, whole genome shotgun sequence.
ACCESSION   DAEHWM010000174 DAEHWM010000000
VERSION     DAEHWM010000174.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4062)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.177"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     regulatory      6..89
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
     gene            669..1346
                     /locus_tag="KNP36_003644"
     CDS             669..1346
                     /locus_tag="KNP36_003644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875470.1"
                     /translation="MYNLLVVDDDVDILNINQIYFSNIGFNVYTSETAKDAMDIVESI
                     VLDCIILDISLPDIDGYKMCNDIKEKVNIPIIFLSNYEHEEEKVRGFLAGGDDYITKP
                     YSLKELELRIYARMRQYKNITSVPNVLKFSALVINVNSRKVTFDGESIDLTTMEFEIL
                     LFLAENKEQVFSKIEIYNQVWKMPDIGDQHTVQVHIAQMRKKINSLSREHQYIQTVWG
                     KGYKFVP"
     gene            1418..3433
                     /locus_tag="KNP36_003645"
     CDS             1418..3433
                     /locus_tag="KNP36_003645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893921.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine kinase"
                     /protein_id="HBF0875471.1"
                     /translation="MKKYNILKGTLIVLIVSLLAITGLNLLYKYDNKYTYKSIRASNG
                     ILTIDNDTFTKGKLVFLIDDWEFYNHKIFKPNDFTEQDIKPEYVFIGQYPDFSMRKGT
                     QSPYGNATYRMRIKNEGKDKLLSLELPEIFSASEVWINGEMVSKLGDVGTEKYRPKIK
                     NSVVSFIAKKNTEIIINVSNFSHYYSGLYYPPALGETKDISNMMFYRLLFYSIICFTT
                     FAIAIFSLSVWFLSNKSKIYLYFGCMCVFFAIHVSYPFVHLLGLPLVSFTYAVEDLSY
                     FMVVLCIICINGSISKIEENKVYRFLILPLGITMSIISIVIPIILLPYDMYFVNIYGK
                     LIDIYKYIVFIYILMSSLVSIYKKTCSEHISSYILVSVNTVFGISILFDAVTSNRFEP
                     IFTGWQTEYCGFVIVILFSVMMINRNRIIIKENEKLTRNLEHEVEVRTNELTTLLNER
                     KRFLADVAHDLKAPVSAIQAFIDLIKVGNIHVDEETRTYLYAINQKSNEVQNRVRSLQ
                     EFTSQDKSIGISEKICLNNFIKEIYENNLPDTQACGVNFETYVLEKKIYAKINKEMLT
                     RAFENLIYNALTFTPFDGKIILSMDKEDGFAIIKISDNGKGIPPENIPKVFDRFFTER
                     DNNEPKGQGLGLYIVKSIIREHGGEIFVDSELGKGTVFTIKLSLYFL"
     gene            3483..>4062
                     /locus_tag="KNP36_003646"
     CDS             3483..>4062
                     /locus_tag="KNP36_003646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875472.1"
                     /translation="MQTKILIIDGDKDNCKKLKGFLEEKGISIDLAYNCEEAIGKIFS
                     NKYDLIFLEIILSDGDGWTLCKKIRNVTTCPIVYMTYINEDQSILNALNSGGDDYLIK
                     PLNLEILYAKVKAILRRMNSYVNNNENNTKLEEYNRTSGVIKLEDKIIKLTPTENKLL
                     NFFIENPEKTLTTKEIYEHVWMNEYLEDNYSVV"
BASE COUNT         1602 a          399 c          681 g         1380 t
ORIGIN      
        1 ataaaaatat tttagaaact gagaagtata tcttattatt gggcatctag agatatatgg
       61 agttagtggt gcaaccggct atgaatataa tttttatatt gcatagtctt tttttgtttt
      121 aaaattaaca aatatgttgc aaaatttgaa aataagagta ttagtcgtta agatttttat
      181 tgataggtaa aattttggct tttaaagtag ccatttgttg gaaaagggaa atttttttaa
      241 aagaataata gtattataat aagaaaataa agtttttata aacattgaga tgcagaatat
      301 aaaccttttg taacaatata tttaccaaaa taatacaatt tattttatat tataaccata
      361 taaatcatat aaatcaatac tcaaactagc caatagacaa gtttctagaa aaataataaa
      421 tttatacgtg aaaatgactt taagctccat tctccaacaa tcggagactt taattagtat
      481 ttaataatga atcttaatgt ttaatacaat attcaagaat tattcaaaaa tacttaagta
      541 ttatagtcta gtttgtaaag atattataaa ataataatac cagttatata tgaaaataaa
      601 acattataat ttgtaataac tataaaactt ggaattataa ttaaaatacc tttgaatgga
      661 gtggtgtaat gtataattta ctggttgtag atgatgatgt tgatatttta aacataaatc
      721 aaatttattt ttctaatata ggttttaatg tatatacatc agagactgct aaagatgcta
      781 tggatatagt agagagtata gttttagact gtataatttt ggatatttca ttgccagata
      841 tagatggata taaaatgtgc aatgatataa aagaaaaggt taacatacct ataatatttt
      901 tatctaatta tgagcatgaa gaagaaaaag ttcggggatt tttagctggg ggggatgatt
      961 atataacaaa accttatagt ttaaaagaac ttgaacttag aatatatgct cgtatgaggc
     1021 agtacaaaaa tattacatca gttcctaatg tgttaaagtt ttcagcgtta gtaataaatg
     1081 taaattcaag aaaagtaact tttgatggag aaagtataga tttaactact atggaatttg
     1141 aaatattatt gtttctagct gaaaacaaag aacaagtatt ttcgaagata gagatatata
     1201 accaagtttg gaaaatgcct gatattggag atcaacatac agtgcaggtt catattgcac
     1261 agatgagaaa aaaaattaat tctttaagca gggagcatca atacattcaa accgtatggg
     1321 gaaaaggata taagtttgta ccataagtga gatactgtaa ttaataaata gttcttgttt
     1381 tatttaatac tactatgaaa gagatgtggt tgatacaatg aaaaagtata atatactaaa
     1441 aggaactctc attgtattga tagtctctct gttggcaata acaggattaa atcttctgta
     1501 taaatatgat aataaatata catataagtc tattagagca agtaatggaa ttttaactat
     1561 agataatgat actttcacta aaggtaaact tgtctttttg atagatgact gggagtttta
     1621 taatcataaa atatttaaac cgaatgattt tacagagcaa gatataaaac cagaatatgt
     1681 ttttataggt caatatccag atttttctat gagaaagggg actcagtcac catatgggaa
     1741 tgctacttat cgtatgagaa taaaaaatga aggcaaggat aagctactaa gtttagagct
     1801 tcctgagatt ttttccgcaa gtgaagtatg gataaatgga gaaatggttt ctaaattagg
     1861 agatgtagga acagaaaaat atagacccaa aattaaaaat tcagtagtaa gttttattgc
     1921 aaagaaaaat acagaaatta taatcaatgt atcgaatttt tcacattatt atagtggttt
     1981 gtattatccg cctgcattag gagaaacaaa ggacataagt aatatgatgt tttatcgatt
     2041 acttttttat agtataattt gcttcacaac ttttgcaata gctatatttt cattgtctgt
     2101 atggtttctt tcaaacaaaa gtaaaattta cttatatttt ggatgtatgt gtgttttctt
     2161 tgccatccat gtatcctatc cctttgtaca tttgttagga ctgcctttgg taagctttac
     2221 atatgcggtt gaagatttgt catattttat ggtagtttta tgtattattt gtataaatgg
     2281 aagtatatcc aaaatagaag aaaataaagt gtacagattt ttaattttac cattaggaat
     2341 tacaatgagt atcatatcta tagtgatacc aattattctt cttccatatg atatgtactt
     2401 tgtcaacata tatgggaagt taatagacat atataaatat attgtattta tatatatatt
     2461 aatgtcttcg ctggtttcaa tatataaaaa gacatgctct gagcatataa gttcttatat
     2521 tttagtttca gtaaacactg tttttggaat tagcatatta tttgatgcag ttacgagtaa
     2581 tagatttgag cctatattta cagggtggca aacagaatat tgtgggtttg taattgttat
     2641 tttattttct gttatgatga taaacaggaa tagaataata ataaaagaga atgaaaaact
     2701 tacaaggaat cttgaacatg aagttgaagt gagaactaat gaacttacaa cattgttaaa
     2761 tgaacgtaaa agattcttgg cagatgtagc acatgattta aaggcacctg tttcggctat
     2821 acaagcattt atagatttga taaaggttgg taatattcat gtagatgaag agacaagaac
     2881 ctatctttat gctataaatc aaaagtcaaa tgaagtacaa aatagagtac gtagtttgca
     2941 agaatttaca tcacaagata aaagcattgg tattagtgaa aaaatatgtc tgaataattt
     3001 tattaaagag atatatgaaa ataatttgcc agatacacaa gcatgtggtg taaactttga
     3061 aacttacgta ttggagaaaa aaatatatgc aaagataaat aaagagatgc ttacaagagc
     3121 atttgagaat ttaatttata atgctttgac ctttactcca tttgatggaa agataatttt
     3181 atcaatggat aaagaagatg gatttgcaat tattaaaatt tctgataatg gaaaaggtat
     3241 acctccagaa aatataccaa aggtatttga cagattcttt acagaaagag acaataatga
     3301 gccaaaaggg caagggttag ggctatatat tgtcaaatcc attataagag agcatggtgg
     3361 agaaatcttt gtagattcag aactaggaaa aggaactgtt tttacaataa aattaagtct
     3421 atatttttta taataatagc ttatttaata taaaagaata atgatatttg ggagtgatta
     3481 taatgcaaac taagatattg ataatagatg gagacaagga taattgcaag aagctaaaag
     3541 gatttctgga ggaaaaagga ataagtatag atttagcata taattgtgaa gaagctattg
     3601 gaaaaatatt tagcaataaa tatgatttaa tatttttaga aataattcta agtgatggtg
     3661 atggatggac tctttgtaaa aaaattagaa atgtaactac ttgtccaatt gtttatatga
     3721 cttatataaa tgaagaccaa agcattttaa atgctttaaa ttctggtgga gacgattact
     3781 taataaagcc tctaaattta gaaatattat acgcaaaagt aaaagctatt ttaagaagaa
     3841 tgaactcata tgtaaataat aatgaaaata atacaaaatt agaggaatat aatagaacta
     3901 gtggagtaat aaagttagaa gataaaataa taaaattgac tccaacagaa aataagttgt
     3961 taaacttttt tatagagaat cctgaaaaga ctttgactac taaagagata tatgaacatg
     4021 tatggatgaa tgaatactta gaggataact atagtgtggt ag
//
LOCUS       DAEHWM010000175         3720 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.178, whole genome shotgun sequence.
ACCESSION   DAEHWM010000175 DAEHWM010000000
VERSION     DAEHWM010000175.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3720)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.178"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            99..605
                     /locus_tag="KNP36_003647"
     CDS             99..605
                     /locus_tag="KNP36_003647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HBF0875473.1"
                     /translation="MKEYVVVDLETTGLDPYKGCEIIEIGITEIKNEQIVKNYSRLIK
                     PKGIISSFITELTHISNEMVENEEPLELVLPRFRKYIGDRTIIAHNAKFDLKFLNYYL
                     RMLDLEPINNYICTVELLKKCKSYKGKNKKLETACAYYNIENINAHRADSDTLATAKL
                     FLKIKDEY"
     gene            733..1749
                     /locus_tag="KNP36_003648"
     CDS             733..1749
                     /locus_tag="KNP36_003648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430829.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase domain-containing protein"
                     /protein_id="HBF0875474.1"
                     /translation="MGYYNDNDNNKIRRKKISNSKDSNKKSKHSYTPANKKNKSSKTS
                     SSKRMSEKVDSQNLIKRDRDSFTRDNVRPLNTDYNQRERRRVEYKQREKKLKSKKRKK
                     QKRIRIVRALLSIMLVALIIFSVAGAIFTVSAIKGSPEVTKKLIRSKYISSEVVSIKQ
                     MPNDLKHAIVSIEDERFYKHKGVDVISLVRSVLNNVFTDTTQGASTIDMQVSKNLLTS
                     NDKTMKRKIRDMYNAKQMNKIMTKDEILEAYLNNMYLGKNAYGAAKGAEVYFGKKVSE
                     LNLAECAMLAGMTNNPARYIDHGEAKKRQVIVLYKMHQLGYITDKEYRIAKADDTPFK
                     SEID"
     gene            2103..2807
                     /locus_tag="KNP36_003649"
     CDS             2103..2807
                     /locus_tag="KNP36_003649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="B3/4 domain-containing protein"
                     /protein_id="HBF0875475.1"
                     /translation="MKKFVIEDAFWNLFPSAKIGVVICNDIDNSIKDEDYKKIILKGE
                     EEALKYLEDSEFSNNQVIKVWREAFKKFKTKKGARSSIEALLKRVHNGNNIGTINPLV
                     DIYNFISLKYALPCGGEDIDKFIGDIRLTRAIGNEEFIPLGTDENSFPYEGEIIYKDD
                     GGAICRCWNWREAVRTMLTEDTNNAFLCIELVDESRFKEFENALNELAKIVQEKLGGN
                     CKISILDIDNKEVSVD"
     gene            3102..3581
                     /locus_tag="KNP36_003650"
     CDS             3102..3581
                     /locus_tag="KNP36_003650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2975 domain-containing protein"
                     /protein_id="HBF0875476.1"
                     /translation="MSNKLIKNLLSGILQILFFLLGLVIVAGGFKSFMYLCFSGEATL
                     QGTIYGILMFILGVSYFIIIKSLIEVLGSSEYSLFVKENVKRFRIIGYLLLLNSLIEF
                     ISTFGTTGKGMRFLDLGFGFYFTVPVFVYFITSLMSFVIADGFVKAIKIKEDNDLTI"
BASE COUNT         1539 a          336 c          636 g         1209 t
ORIGIN      
        1 tgtaaaatct tcctatatca tataaaatta agtattgatt agtctattac ataaatatag
       61 aatataaata tatccattta ataataagga gaagagatat gaaagagtat gtagttgtgg
      121 atttagaaac tacaggatta gatccatata aaggttgtga aataatagaa ataggaataa
      181 cagaaataaa aaatgaacaa attgtaaaaa actattcaag gttgataaaa cctaagggga
      241 taatttcttc atttataaca gaattgacac atataagtaa tgaaatggta gaaaatgaag
      301 aaccactaga attagtttta cctagattta gaaaatacat aggtgataga actataattg
      361 cacacaatgc gaaatttgat ttaaaatttt taaattacta tcttagaatg ttagatttag
      421 aaccaataaa caattatata tgtacagtag agttattaaa aaaatgtaaa agttataaag
      481 gaaaaaacaa gaaacttgaa acagcttgtg cttattacaa catagagaat ataaatgctc
      541 atagagctga cagtgataca ttagcaactg caaaactatt tttgaaaata aaagatgaat
      601 attaattata aatatagaga aaattagtga aaatatcctt tataaaattg acccttaagc
      661 ttacaatttt gttctttgat ttattttgta gaacaatgta taatgtacct tatatgaaga
      721 agggagacta aaatgggtta ttacaatgat aatgataata ataaaataag acgtaaaaaa
      781 attagtaaca gcaaagatag taataaaaaa tctaaacatt cttatactcc ggcaaataaa
      841 aaaaataaaa gttctaagac aagttctagt aaaagaatga gtgaaaaagt agattcacag
      901 aatcttataa aaagagatag agatagtttt acaagagata atgtaagacc tttaaataca
      961 gattacaatc aaagagaaag aagaagagtc gagtataaac aaagagagaa aaaattaaaa
     1021 agtaaaaaaa gaaaaaaaca aaaaaggatt agaatagtta gagcattatt atctattatg
     1081 ttagttgcac taattatatt ttcagtggca ggtgcaatat ttacagtttc agctataaaa
     1141 gggtcaccag aagttactaa aaagttaatt aggtctaaat atataagtag tgaggttgta
     1201 agtataaaac aaatgccaaa tgatttaaaa catgcaatag tttccataga agatgagaga
     1261 ttttataagc ataaaggagt agatgttatt tctctagtta ggtcagtatt aaacaatgtg
     1321 tttacagata caacacaagg tgcaagtact atagatatgc aagtttcaaa aaacctgctt
     1381 actagtaatg ataaaactat gaagcggaaa ataagggata tgtataatgc taagcagatg
     1441 aataagatta tgactaagga tgaaattctt gaagcatatt taaataatat gtatctaggt
     1501 aaaaatgcat atggagctgc aaagggagct gaagtctact ttggtaaaaa agttagtgaa
     1561 ttaaatttag ctgagtgtgc tatgttagct ggtatgacaa ataatcctgc aaggtatatt
     1621 gaccatggag aggctaagaa gagacaagtg attgtactgt ataagatgca tcagcttggt
     1681 tatataactg ataaggagta tagaatagca aaagctgatg acactccatt taaatcagaa
     1741 attgattaaa attgtaagaa tatagtattt tcaatagttt aaacaaacaa aaatgtaata
     1801 aaaaaggtga tttgccaccc atttgccacc ataattataa tctaatggca aattgtttta
     1861 atgtacaaac tagataatag aatattgtct taaatgctat attatgctaa aatttaattg
     1921 tattttgtaa attaaaaaac ttataattta gttttctagg gttccgcatt ttataatggt
     1981 caggtccaag agaaaacgcg caattgttgt gtacacggaa ggataaaagc ctgggagata
     2041 tttaagaata tttctatagg cttttttatt tttacatatt ttaaatttga ggaggttttc
     2101 taatgaaaaa atttgttatt gaggatgcat tttggaatct atttcctagt gcaaaaattg
     2161 gagttgttat ttgtaatgat atagataact ctataaaaga tgaagactat aagaaaataa
     2221 ttttgaaggg agaagaagaa gcattaaaat acttggagga ctcagaattt agcaacaacc
     2281 aagtgattaa agtatggaga gaagcattta aaaaatttaa aacgaaaaaa ggagcaaggt
     2341 cttctattga agcattatta aaaagagttc ataatggaaa taatatagga actattaacc
     2401 ctttagtgga tatctacaat tttatctcat taaaatatgc attaccttgt ggaggggagg
     2461 atatagataa atttatagga gatattaggc taactagagc aattggtaat gaggagttta
     2521 tcccactagg gacagatgaa aattcatttc catatgaagg agaaataatt tataaagatg
     2581 atggtggagc aatttgtaga tgttggaatt ggcgtgaagc agtgagaaca atgcttactg
     2641 aagatactaa caatgccttt ttatgcattg aattagtaga tgaaagtaga tttaaagaat
     2701 ttgaaaatgc tttaaatgaa ttagctaaaa tagttcaaga aaaattgggt gggaattgta
     2761 aaatttcaat tttagatatt gataataaag aggtatcagt ggattaatat ggaggtgctg
     2821 ttgtaatgga ctattctagt tataaagata cttatattta gggtaagaag gtctatttta
     2881 gatataacga ttatcaaagg atataatata gaaaataaaa atgtagaata taaaaagcct
     2941 ttaaaataag aaaaaaatgt attttaaagg cttttattat actctttttt atttgcataa
     3001 ttaacaataa aaatatattg ttaattataa tatttttatt gaaaaacgat ataatataat
     3061 gtattatact atatataaaa tattttaaag gagttggcat gatgtctaat aaacttataa
     3121 aaaatttact aagtggtata ttacaaattt tattttttct tttaggatta gtaattgttg
     3181 caggaggatt taaaagtttt atgtacctct gttttagtgg agaagcaact ctacaaggta
     3241 ctatttatgg aatattaatg tttattttag gtgtatcata ttttatcatt ataaaatcat
     3301 tgatagaagt attaggtagt tctgaatata gcctatttgt aaaagagaat gtaaaaagat
     3361 ttaggattat tggatatctt ttgcttttaa actctctaat tgagtttatt tcaacttttg
     3421 gtactactgg aaaaggaatg agatttctag atttaggatt tggattttat tttactgttc
     3481 cagtatttgt atattttata acttctctta tgagttttgt aattgcagat ggatttgtaa
     3541 aggcaataaa gataaaagag gataatgatt taactattta gatgtgacac tttaatatat
     3601 aggagataaa taacccgaaa agagtgacta actagtaatt taaaataaaa tatattaggg
     3661 tataatacat aaactataat gctaaaatta aaagattata atactaaaat ataattatgt
//
LOCUS       DAEHWM010000176         3715 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.179, whole genome shotgun sequence.
ACCESSION   DAEHWM010000176 DAEHWM010000000
VERSION     DAEHWM010000176.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3715)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.179"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            455..1984
                     /locus_tag="KNP36_003651"
     CDS             455..1984
                     /locus_tag="KNP36_003651"
                     /inference="COORDINATES: protein motif:HMM:NF012862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="caspase family protein"
                     /protein_id="HBF0875477.1"
                     /translation="MKSLKALIVGVSKYSIVKNKDLLFCKNDIIEINNVLHKRLGITS
                     NNIRTLGMEYEVRKDLFFKTFQEISDSIGDDDTFIFYFSGHGCICNNGVHYLVLSDEL
                     VSIQFVIDFIEGLNCKNKIVFIDCCFAGKFNVSDKQKINIKDIFSLFDRKGCAVLVSS
                     SEYQESFSLPDSSISRFTSLLSEALRNEYIVRKGELSLRAISKYINLRMSILNKNYIN
                     CKQNPIFRSNILGDIYFNVKDYKSYIKKKVFQEHDDYIIYNVKSLHISIIKRYSVEVI
                     LKNKFSYCDISEISKEVFDIVKSVEVYNSEIGEDRLKGKDANIIWVYFGKDEIDMING
                     IYMCKTTWIDKYQEKDIWYSVNGKNKFFINGVHTETYDNYESLKSYISQNTITKEKAV
                     YEVKEILTNMINISEEIISFYNEYENKKICEDNIFQIIDSRKKKMDECYNKVINLDFP
                     PIEIKDWFDKCINLVSTIQNFGVYWDHSRTEENRKQCMEMNIEDYYKDLREVIRLSEE
                     I"
     gene            2533..3208
                     /locus_tag="KNP36_003652"
                     /pseudo
     CDS             2533..3208
                     /locus_tag="KNP36_003652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438019.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
BASE COUNT         1648 a          341 c          511 g         1215 t
ORIGIN      
        1 aactttagaa atgtatgtat aattttataa ataaagcata acaatttaaa taaatacttg
       61 agggaataaa atgatattaa ataagatata aatgattgga aatatttact cactttaaaa
      121 ttcttatgga tagtagaata caaaaaacac atgaaattct attaacatca atattttggg
      181 gaattttaaa aaatatatgg tgaagagata gatgatttta cattggttta aattacacta
      241 agttcaggtc agataaatca gagatataaa ttatatgggt gcgatgtaaa taaatatata
      301 tatacttacc ttgaaaaatt ataatccaac tacaaaagta aataatgaaa aagtcaaaaa
      361 agtagtgtga tactagcttt tataaaatca ataaaacaat taaaacatca ttttaagtat
      421 attaaattga aaaattataa agggggaatg gaatatgaaa agcttaaaag cattaattgt
      481 aggagtaagt aaatatagta tagttaaaaa taaagattta ctattttgta aaaatgatat
      541 aattgaaatt aataatgtgt tacataaaag actggggatt acttcgaata atataagaac
      601 tttaggtatg gagtatgaag tcagaaaaga tttatttttt aaaacttttc aagaaataag
      661 cgattctata ggagatgatg atacatttat attttacttt tcagggcatg gatgcatatg
      721 taataacgga gtgcattact tagtattaag tgatgaatta gtttctattc aatttgtaat
      781 tgattttata gaaggattaa attgtaaaaa taaaattgta tttattgatt gttgctttgc
      841 aggtaaattt aatgtaagtg acaaacaaaa aataaatatt aaagacatat tttccttgtt
      901 tgatagaaaa ggatgtgcag tgttagtatc aagtagcgaa tatcaagaat cattttctct
      961 tccagatagt tcaattagta gatttacaag tttattatca gaagcgttaa gaaatgaata
     1021 catagtaaga aaaggggagt tatctttaag agcaataagc aagtatatta atttgcgtat
     1081 gagtatattg aacaaaaatt atataaactg taaacaaaat cctatcttta ggtctaacat
     1141 actgggagat atatatttta atgtaaaaga ttataaatct tatataaaaa agaaagtttt
     1201 tcaagagcat gacgattaca taatatacaa tgtcaaatct ttacatataa gtataataaa
     1261 aagatattca gtagaagtta tattaaaaaa taaattctcc tattgtgata tatcagaaat
     1321 atctaaggag gtttttgaca tagttaagtc tgttgaagtt tataatagtg aaataggaga
     1381 agatagatta aaaggaaaag atgctaatat aatatgggta tattttggca aagatgaaat
     1441 tgatatgata aatggaatat atatgtgtaa aactacttgg attgataaat atcaagagaa
     1501 agatatatgg tatagtgtaa atgggaaaaa taaatttttt atcaacggtg ttcacactga
     1561 aacatatgat aactacgaaa gcttaaaatc atatataagt caaaatacaa tcactaaaga
     1621 aaaggcagta tacgaagtta aagaaatttt aacaaatatg ataaacatat ctgaagaaat
     1681 tatatccttc tataatgaat atgaaaataa gaaaatatgt gaagataata tttttcaaat
     1741 tatagatagt agaaagaaaa aaatggatga gtgttacaat aaagttataa atttagattt
     1801 tccaccaatt gaaattaaag attggtttga taaatgtata aacttagtgt caactataca
     1861 aaattttgga gtttattggg atcatagtag aactgaggaa aatagaaagc aatgtatgga
     1921 aatgaatata gaggattatt acaaagattt aagagaagtc ataagattaa gtgaggagat
     1981 atagaattaa atttttccat agttgtacta atatagaatt ataagtcaga ttggtacttt
     2041 gttggttacg aatttaaatt aaaataagtt gtttacacta aacatgatag aagatacaat
     2101 tataaatcca tttataaatt atattggtat tgatttaaat aattagatat ttattttgaa
     2161 aaagtctagt aaatatttaa aaacgtataa tatgctgtta atggaacttt tataaaatta
     2221 aaagattata tcatccaccc cccccccaat aataccccaa ctacaaaaat aaacaataaa
     2281 aaatatccga aaaaatcagt ttaacatcat aactaaatag ctatatacct acacttgcaa
     2341 aaaacaacaa aacaatcaaa taaccactta tagactcccc tcgtctccac cattgaaatc
     2401 cacgaatacc tatatccaat tggatatagg tatttttata catttttaat ttaaatatta
     2461 ttgataaata catttaaaaa gttttaacct aaagtgaaga atctaaataa aaatacaata
     2521 ttaggagagg ttatcattac aataacagct tgtgatgatg aaaaagaaat acaaatcgta
     2581 ataaaaaatc aagttgataa tatattaaaa aataaaaaca aagaatatcg aattaaaaaa
     2641 atatagctca aaagaagaat cattacaaag ttaattgaga ggatacacta ctcttagata
     2701 taaaaatggc agaactaaat agtatagata tcgcaagaaa cataagaaaa gtagataata
     2761 atatttataa catctctaat aaattatgta caggaaagat atgaagtaag agcttattga
     2821 tacttattaa agccaataaa ttttcaagaa ctagaaaaac acatattaac atgtaccaaa
     2881 aaaattgaaa aaaataaaaa taaatctaac acatacaaaa tctaatctag caaaaaaata
     2941 tatagaagtt caaaaaaaga acatgctaat acatacaaaa aataaaactc ttgatgctat
     3001 atgtatccta gaaaaaatag aaaaagattt aaatatagag gaacttgtaa gatgtcataa
     3061 aagttatata actaacttaa actatgtaga aaatataaag tcaaatactg caatattaga
     3121 cagtcaagaa gaagtaccta ttagtagata tagatataaa gatataaaag aggggtttct
     3181 aaaatttatt ggtgatagaa tatgttaaac catataaata aaatattatt aatattatca
     3241 ttgtttacac caataatgat actaaaaagt atattaactt acgataaaga tacagataag
     3301 actaagaaaa tatctttttt tactgtatta ttagcttatc ttataactaa gatcattata
     3361 ttatttaatg ttgataagac ccatgattat aatatgaaga aaaatctata tgatataatc
     3421 tattatttga tatttattac ttgggaactt actataatta tttttataag ataggaattg
     3481 ttaaatatat agtttcattt ttcttatttg acgtatatca ccctttaata aaagatgtta
     3541 tatctataaa tttatttttt gtagttacaa gtaatgtaat atcatcagag gaagctctat
     3601 tagtgtttag ttatgataat gctaaagtag atatatacta ttatcttata ataatagtta
     3661 tatagtagct tgtgctatat ttaaatttat taataaaaga ttgggactag ataaa
//
LOCUS       DAEHWM010000177         3631 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.180, whole genome shotgun sequence.
ACCESSION   DAEHWM010000177 DAEHWM010000000
VERSION     DAEHWM010000177.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3631)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3631)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3631
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.180"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            24..677
                     /locus_tag="KNP36_003653"
     CDS             24..677
                     /locus_tag="KNP36_003653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893713.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="HBF0875478.1"
                     /translation="MTKIIKVQKPKFTGELEIIENLEDILEDIFNDEKIFNKIIENEV
                     ISDLDSVRVSFESCIFRNVSFENCNLKKIDLLDVVFENCNLSNTFFDGGSIYRVEFKN
                     SKLIGVRFDDCILKNVLFKDVLGKYSNFSFSKFKIVSILDSNFENSVFQEVKGDNLVF
                     EYTNLKKANFNGTKLSGIDFTTNNIEGIEIGIDDIRGAIFDVSQAIDLTKLMGIIIK"
     gene            818..2089
                     /gene="brnQ"
                     /locus_tag="KNP36_003654"
     CDS             818..2089
                     /gene="brnQ"
                     /locus_tag="KNP36_003654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004455013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HBF0875479.1"
                     /translation="MRDIFIVGFALFSMFFGAGNLMFPPFLGMESGKDWLIPLIGFVV
                     ADAGIAMLVIIATARCKGSMDDVLRRAGKGLARVMSVAALACLALLVIPRTCATTYEM
                     GIMPIFGDHGPVAKAVFSIIFFGLTLAFTIRSSKVIDIIGKYLTPALLLVLFVLIVKG
                     IISPAGPMSPEHMIDKNLFGEGISQGYQTMDALGAASMATIMLMSIIAKGYTSDKDQI
                     GMTIKAGFVACVFLAVVYGGLTYLGATVSTLYDTSIPQASLLVEITSILLYGQVGKVI
                     LGVIVALACLTTSTGLTASISTYFEGISKASYKQLVIGICVASMLISNLGVDSIIAIS
                     VPILQTIYPVLLAIVVMELAGKHIKNDNAFKGAAYVTLVISLLSAINGMTGAVPFIQS
                     LPLAGLGFNWVIPAILGGIVGNFIKSNKQVA"
     gene            2291..3478
                     /locus_tag="KNP36_003655"
     CDS             2291..3478
                     /locus_tag="KNP36_003655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3798 domain-containing protein"
                     /protein_id="HBF0875480.1"
                     /translation="MLRKITAFMLSICLIIGLTGCSLLVGKKDKEKIIDDFKVAVVTQ
                     PLSENKVQYNMVEEMAKEYEEENKIDKDKDGQTKVKQTIKHVVLPENFTSNIDSAINK
                     IVKLADDKEVQAIVVSTDQAGLLPALQKVKEKRPEIITISAPMGDDKNQLSQFVDVNL
                     GVSAEERGKVLAERSKEMGAKAFIHYASTDDLKDVNIAKRLEMIKETCKNIGLPFVQV
                     NTPNINTEEDKNKVKQFLNEDIEKQVKKYGKDINVFGVNEYMDEVILTKALELKYIVA
                     EQSNPSPIQTYPSVMGLKISEKDAQNYDKINDMISEKAKAFGMSNRLGGYPMPMDAFL
                     PSVAIYLATEMVKQDLTQEDVCDPDYLEAFTELRFGIGSEFTPLTEVLYNYQSVILSQ
                     LIY"
BASE COUNT         1322 a          400 c          669 g         1240 t
ORIGIN      
        1 tataatttat agtggagggg aaaatgacta aaattattaa agtgcaaaaa cctaaattta
       61 caggagaatt agaaattatt gaaaatcttg aagatatact tgaagatata tttaatgatg
      121 aaaaaatatt taataaaatt atagaaaatg aagttataag tgatttagat tctgtaagag
      181 ttagctttga atcttgtata tttagaaatg tgtcttttga aaattgtaat ttaaaaaaga
      241 ttgatttact tgatgtggta tttgaaaact gcaatttatc aaatacattt tttgatggag
      301 gaagtatata cagagttgaa tttaaaaata gtaaattgat aggagttaga tttgatgatt
      361 gtatacttaa aaacgttttg ttcaaggatg ttttaggtaa gtattctaac ttttcattct
      421 ctaaatttaa gatagtttct atcttagatt caaattttga aaattctgta tttcaagaag
      481 taaaaggtga caatctagta tttgagtata caaatttaaa aaaagcaaac tttaatggaa
      541 ctaaactttc tggcatagat tttactacta ataatattga gggaattgag attggtatag
      601 atgatattag aggagcaatt tttgatgtgt cacaagcaat tgatttaacg aaattgatgg
      661 gaattatcat aaaatgaaaa aaatattcat aaaataaatt gggaaaacgt taacaatgtg
      721 tgaattttta ccagattgac atttttctga aaataaagta agattatctt aatattcaaa
      781 atattttcaa agggggtaat ttagtgtgag taagcagatg agagatattt ttatagttgg
      841 ttttgcttta ttttctatgt tctttggtgc aggaaatctt atgtttcctc catttttagg
      901 gatggaatcc ggcaaagact ggttaattcc tcttattgga tttgttgttg cagatgctgg
      961 tatagcaatg cttgttatta tagcaacagc aagatgtaag ggaagcatgg atgatgtact
     1021 taggagagct ggtaaagggt tagcaagagt aatgagtgta gctgctctag catgtttagc
     1081 acttcttgta ataccaagaa cttgcgcaac aacatatgaa atgggtatta tgcctatatt
     1141 tggagaccat ggtccagtag ctaaagctgt attttcaata atcttctttg ggctaacttt
     1201 agcatttact attaggtctt ctaaggttat agacataata ggtaagtatt taactccagc
     1261 gttattatta gtattatttg ttttaatagt aaagggtata atttctccag caggacctat
     1321 gagtcctgag catatgatag ataaaaatct atttggtgaa ggtatatcac aaggttatca
     1381 aacaatggac gctctaggtg cagcatctat ggcaactata atgttgatgt ctataatagc
     1441 taaaggatat acatcagata aagaccaaat aggaatgact attaaagctg gttttgtagc
     1501 ctgtgtattt ctagcagtag tatatggtgg tcttacttat ttaggtgcaa cagtttcaac
     1561 tttatatgat actagtatac ctcaagcatc tttattagtt gaaataacta gtatattgtt
     1621 atatggtcaa gtaggaaagg taattttagg tgtaattgtg gcacttgcct gtctgactac
     1681 ttctacaggt ttaacagcat caatatcaac ttattttgaa ggaataagta aggcgagtta
     1741 taaacaactg gttataggta tatgtgtagc tagtatgctt atatcaaatt taggtgttga
     1801 ttctataata gccatatcag ttccaatcct acaaactata tatcctgttt tattagcaat
     1861 agttgttatg gagttggctg gtaaacatat aaagaatgat aatgctttta aaggtgcagc
     1921 atatgttaca ttagtgatta gtttattatc agctataaat ggaatgacag gagctgttcc
     1981 atttatacaa agcttgccac ttgcaggttt gggctttaac tgggtaatac cagctatatt
     2041 gggtggaata gttggtaact ttataaaaag caacaaacaa gtagcataat aatttgtaat
     2101 taatttaatt ttataatata ttaattttta gtactatggg taggtttaat ctaaacctaa
     2161 tctacccata gtacttttta gattggatta taatagcatg tatataattt tttataatat
     2221 aatttttctt tgaagtatga taaaattagt aatagtgata agaatgtaca aatttaggag
     2281 gttttaatta atgcttagaa aaataacagc atttatgcta tccatatgtt taattattgg
     2341 acttacaggt tgtagtttac ttgtaggcaa gaaagataaa gagaaaatta tagatgattt
     2401 taaagttgca gtggtaactc aaccattatc tgaaaataaa gtacaataca atatggtgga
     2461 agagatggca aaagaatatg aggaagagaa taaaattgat aaagacaaag atggtcaaac
     2521 taaagttaaa caaactataa agcatgttgt attgccagag aattttactt ctaatataga
     2581 cagtgctatt aataagatag taaagttggc tgacgataaa gaagttcagg ctattgtagt
     2641 ttcaactgac caagcagggc ttttacctgc tttacaaaag gtaaaggaaa agcgtccaga
     2701 aataataact atttctgccc ctatgggaga tgataaaaac caattaagcc aatttgttga
     2761 tgtgaatcta ggggttagtg cagaggaaag aggaaaagta ttagctgaac gttcaaaaga
     2821 aatgggagca aaagctttta ttcattatgc ctctacagat gatttgaaag atgttaatat
     2881 agccaaaaga ttagaaatga ttaaagagac ttgcaaaaat ataggattgc catttgtaca
     2941 agttaatact ccaaatataa atactgaaga agacaaaaac aaagttaagc agtttttaaa
     3001 tgaagatatt gaaaaacaag ttaaaaaata tggaaaagat ataaatgtat ttggtgtaaa
     3061 tgagtatatg gatgaagtta tattgactaa ggctttagaa ttaaagtata tagttgcaga
     3121 gcaaagcaat ccatcaccaa tacaaacata tcctagtgtt atgggtctaa aaatatctga
     3181 aaaagatgct caaaattatg ataaaataaa cgacatgata agtgaaaagg ctaaggcttt
     3241 tggcatgtca aatagacttg gtggatatcc tatgccaatg gatgcttttc taccatcagt
     3301 agcaatttat cttgctactg aaatggtgaa acaagattta acacaagaag atgtatgtga
     3361 cccagattat ttagaggcgt ttacagaatt aagatttgga atcggttcag aatttactcc
     3421 tttaacagag gtactttata attatcaatc agtaatttta agccaattaa tttattaata
     3481 ttaaggacgt gtctcaaaat gaacttttta gtttatgagg cactcttttt ctgttaaatc
     3541 aaatatattt ttatcttttt aacaattaaa aagaagctta tccatatgtt gagatagctt
     3601 cgtttttaat ataaataagt tttattattt t
//
LOCUS       DAEHWM010000178         3567 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.181, whole genome shotgun sequence.
ACCESSION   DAEHWM010000178 DAEHWM010000000
VERSION     DAEHWM010000178.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3567
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.181"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            63..1559
                     /locus_tag="KNP36_003656"
     CDS             63..1559
                     /locus_tag="KNP36_003656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004453549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBF0875481.1"
                     /translation="MFEFETQLKRLKHEVLTAVARLSIEENLTKENIEKIPYEIIKGE
                     KARYRCCVYKEREVVLERAQLALSLTPNSKYGDINPDSVSLDTDEQIIYIVEAACDRC
                     PINEFTVTELCRGCLAHRCKEACKFGAISYINGRAYINHDLCKACGMCKSSCQYDAIS
                     EVVRPCKSVCPTGALDFNRNTMKAMIHEDNCINCGACMSACPFGAISDKSLIAPVAKK
                     LAKKENMYAIVAPAITGQIDSNITYGQLKNAIKSLGFVDMIEASCGADAVTVHESNEL
                     IERIKSGDNYMTNSCCPGFFKYIEKMFPDEKDRISSTVSPMVATGRLVKKIDSDAKVV
                     FIGPCTAKKSEATEKSLKDSVDYVLTFEELMALFEAFNIDLSKCSNEDINDGSIFGRG
                     FGASGGLAKSVQNYIAEKGLSFDFEPIKVSGPRQIKKTMTMAKLGRLEGNFIEGMMCE
                     EGCINGAGKFLSGVKAKNTFDRKNGQSTKKSVLSNDKIKEFEDVNLER"
     gene            1693..2619
                     /locus_tag="KNP36_003657"
     CDS             1693..2619
                     /locus_tag="KNP36_003657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0875482.1"
                     /translation="MRKIVLKDILFLVTTLSIIVILLLVTNITTNSKIKSTSESYLKS
                     DKNSVRQNGIQRSTKSSTKNTAFKTTILNTGKSDCILVEIGNKVIMIDTGEDKNGKQI
                     VDRLKEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDS
                     LKKADIEPVLLKDNMNIVINGAEINIHPASKSKYESSNDYSIITNISYGAHKFLFAGD
                     AEEERLSEFINGNTLKYDFVKMPHHGRYDKLTETFLESISPQYAVITCSEKKEPEEGV
                     LKILERLNIKTFLTSNGEVVINSDGKTLSVNQ"
     gene            2737..2928
                     /locus_tag="KNP36_003658"
     CDS             2737..2928
                     /locus_tag="KNP36_003658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875483.1"
                     /translation="MLDRFFGEGGFGGCAWWIIILFFLFLAFQDCWAEMDLCAWIPFL
                     ILLLILCECGDVFDGGCGC"
     gene            3151..3501
                     /locus_tag="KNP36_003659"
     CDS             3151..3501
                     /locus_tag="KNP36_003659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875484.1"
                     /translation="MAIVDKIFNEIKLMVARLLLGKKYSEYEEKDLVYNTEEEVILIT
                     LKRLVFQGNVNEAEEILFDKAKSVNSENMQYIAIEFYTMLMEKTDEELEAMNFSKQEV
                     YQGIEDIRKVLNLE"
BASE COUNT         1424 a          348 c          677 g         1118 t
ORIGIN      
        1 aatacaatat acataatagt agaaatatag caaaaaggtg tgatttatag ggaggattac
       61 ttatgtttga atttgaaacg caactaaaaa ggttaaaaca tgaagtttta acagcagtag
      121 caagactatc tattgaagaa aatttaacaa aagaaaatat agaaaaaatt ccatatgaaa
      181 taattaaagg agaaaaggcg agatatagat gttgtgttta taaagagaga gaagtagttc
      241 ttgaaagggc gcaacttgca ttaagtttaa ctccaaatag taaatatgga gatataaatc
      301 cagattcagt tagtttggac acagatgagc aaattatata tatagttgaa gcagcatgtg
      361 atagatgtcc aataaatgaa tttacagtta cagagctttg tagagggtgt ttggctcata
      421 gatgtaagga agcatgtaaa tttggggcaa tttcttatat aaatgggaga gcatatataa
      481 atcatgattt atgtaaggct tgtggaatgt gcaaaagttc atgtcaatat gatgctatat
      541 cagaagttgt aagaccttgt aaaagcgttt gtccaacagg agctttggat tttaatagaa
      601 acactatgaa agcaatgata catgaagata attgtataaa ttgtggagca tgtatgtcag
      661 catgtccttt tggagcaata tctgataaga gtttgatagc acctgttgca aaaaaacttg
      721 caaagaaaga aaatatgtat gcaatagtag ctccagctat aacaggtcaa atagatagta
      781 atattacata tggtcagtta aaaaatgcta taaaatcact gggatttgta gatatgatag
      841 aagcttcttg tggagcagat gcagttacag ttcatgaaag caatgaactt attgaaagaa
      901 taaaatcagg agataattac atgacaaatt catgttgtcc gggatttttt aagtatatag
      961 agaagatgtt cccagatgaa aaagatagaa tatcatctac agtgtctcct atggtagcaa
     1021 caggaagatt agtaaaaaaa atagattctg atgctaaagt tgtatttata ggtccatgta
     1081 cagctaaaaa gagtgaggca acagagaaaa gtttaaaaga ttcagtagat tatgtactta
     1141 cttttgaaga actaatggca ttatttgaag catttaatat agatttatca aaatgttcaa
     1201 atgaagatat aaatgatggt tcgatttttg gaaggggatt tggagcatct ggtggacttg
     1261 ccaaatcagt acagaactat attgctgaaa aggggcttag ttttgatttt gaacctataa
     1321 aagtatctgg tccaagacaa attaaaaaga caatgacaat ggctaaattg ggaagattag
     1381 aaggtaattt tatagaagga atgatgtgtg aagaaggttg tattaatgga gccggtaagt
     1441 ttttatcagg tgtaaaagcc aaaaatactt ttgatagaaa aaatggacaa tctactaaaa
     1501 agagtgtttt atctaatgat aagattaaag aatttgaaga tgtaaattta gaaagataat
     1561 tgttttggta cagtcatttt tttattatgc cacaaatatg cctaaaattt gcccttttta
     1621 tatgtgtatt ttacagagtt aaggttgcta tactataaat atgtaataaa taaaatttat
     1681 aggagctttt ggatgaggaa aatagtatta aaagatatcc tgtttttagt tactacatta
     1741 tctataatag taatattatt gcttgtaaca aatataacta ctaatagtaa gataaaatca
     1801 acaagtgaat cttatttaaa aagtgacaaa aatagtgtga ggcaaaatgg tatccagagg
     1861 agcacaaaga gtagcacaaa aaatactgca tttaagacta ctatactaaa cactggaaag
     1921 tctgattgca tattggttga gataggtaac aaagtcataa tgattgatac aggagaagat
     1981 aaaaatggaa aacaaatagt ggataggtta aaagaaaaag gaataaatac acttgactat
     2041 ttgattttaa ctcatttaga taaggaccat ataggtggag tagatagtgt gttatctagt
     2101 gttaaagtaa agaatattat acaagcaaat tataagaaag atagtaagca atatgatgaa
     2161 tatattgact cacttaaaaa agctgatata gaaccagtgc tactaaaaga taatatgaat
     2221 attgtaatca atggtgcaga aataaacata catccggctt caaaaagcaa gtacgagagt
     2281 tcaaatgatt attcaataat cactaatata agctatggag cacataagtt tttatttgca
     2341 ggagatgcag aggaagaaag attgtcagag tttataaatg gaaatacttt aaaatatgat
     2401 tttgttaaaa tgcctcatca tggaagatat gacaaattaa ctgaaacatt tttagagtct
     2461 atttcacctc aatatgctgt tattacatgt tcagagaaaa aagaaccaga ggaaggtgtt
     2521 ttaaaaatat tggaaagatt gaatataaaa acatttttga cttctaatgg agaggtagtt
     2581 atcaatagtg atggtaagac attgagtgtg aatcaataat ttttttaaaa atatctaaaa
     2641 aaatttaaaa aaatcattag caaatattac cccttaaaca tagtatattt taggagctga
     2701 aactccacat acaaaatgac taggaggtaa catattatgt tggatagatt ttttggtgaa
     2761 ggcggatttg gtggatgtgc ttggtggata ataatattat tcttcttatt cttagcattc
     2821 caagattgtt gggctgaaat ggacttatgt gcatggatac ctttcttaat attattatta
     2881 atactttgtg aatgtggtga cgtttttgat ggaggatgtg gatgctaaaa aaatcaattt
     2941 agatgattta ataaagctta tggtgggtat aaataaaata ccaaaccaat cacaatctag
     3001 tgtttgaagg tagtcggaaa tcccccgcta ccttcttttt tttattgtta aaatttattt
     3061 ttgaattatt tcatttacat ataataattt ttacgataaa gtctgatata attaaaaaga
     3121 aaataaaatt tatttatagg agatgtaaaa atggctatag tggataagat tttcaatgag
     3181 ataaaactta tggttgcaag acttttattg ggaaaaaaat acagtgaata tgaagaaaaa
     3241 gatttagtgt ataatacaga agaagaagtt atacttataa ctttaaaaag attagttttt
     3301 cagggaaatg taaacgaagc agaagaaatt ttatttgata aagctaagag tgtaaatagt
     3361 gaaaatatgc agtatatagc aatagaattt tatactatgc ttatggaaaa gactgatgaa
     3421 gaattagaag ctatgaattt ttctaaacaa gaagtttatc aaggtataga agatattaga
     3481 aaagtattga atttagaata aaagatatat gaaaatattg aaataaatta atgctaaggt
     3541 gagaatatta tacttatata taaaaat
//
LOCUS       DAEHWM010000179         3566 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.182, whole genome shotgun sequence.
ACCESSION   DAEHWM010000179 DAEHWM010000000
VERSION     DAEHWM010000179.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3566)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3566)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3566
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.182"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            116..1009
                     /locus_tag="KNP36_003660"
     CDS             116..1009
                     /locus_tag="KNP36_003660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HBF0875485.1"
                     /translation="MQLYNTPFNTNKHLIYFFTFTLVLNWIFSLTPALLGITNTILGE
                     IIFYLAYTSPAIVGLFFISTIYPQSAKQDFIYRYLSFKEIGIKWILLTILFFALTFIT
                     SLIIGNYFNVKTSDIDWIHIAVFRPSKIAYMLLASFILSILSQEAGWRGYAIDKLLVR
                     FGFIGSSIILGLVCGIWYLGSYFTPNQIPYNLAQYSLFDAFLFIPNIVLLNFIINFVY
                     INTSRSILSAGLVHMMYYFFNIQLLLHYPIKLCVIAQYVQIIFGLIFLVYMISSNKFK
                     QKVNSEIEQIKSDDFEFELDW"
     gene            1187..2011
                     /locus_tag="KNP36_003661"
     CDS             1187..2011
                     /locus_tag="KNP36_003661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0875486.1"
                     /translation="MFKIGEVSKLTQISIRMLRYYDELGILKPAKTDKYTGHRLYSVE
                     QISILQRIVLLRDSKFSVAEIANIVHNWNDEFVIKELNRKKNEIQKEIKQEQQRINKI
                     DKFIEAINCDKDEIHYNVVFKKIPSYKIISLREIIPDYQSEGILWEKLSKFIKEEHIE
                     VSRQSNNNIAFYHDEEVKDNGVDIEVGMVVKKIGKNKSGFIYRETEEIDMMACTMVYG
                     PYENIAGAYESFCYWLDKNSDYQISGINRQIGHKGEHNEINPENYLTEIQIPLIKV"
     gene            2110..2718
                     /locus_tag="KNP36_003662"
     CDS             2110..2718
                     /locus_tag="KNP36_003662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0875487.1"
                     /translation="MEKLLRGKIMKADSTKEQLINATIQLLSSHRDVSSITAREIVAK
                     ANVNLAMINYYFKSKEELINISIKKFLKRHMDEYKATHDTKNLAPKQQLREILIAFFD
                     FIGEHSQFIKISVPYILIQEEIVYPFEILPLIKAHYENQNNKKTEAEYRTIAYQITSF
                     IQLLFLRSNAFFKYSGIDILNIEQRNGLIDFQLDLLLVDITK"
     gene            2822..2998
                     /locus_tag="KNP36_003663"
     CDS             2822..2998
                     /locus_tag="KNP36_003663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875488.1"
                     /translation="MFFTFIGVISAILLLCTIICGLWIKLNNRNNDSNSHFTFSILSI
                     AFSLLIVVAFLVRN"
BASE COUNT         1306 a          433 c          480 g         1347 t
ORIGIN      
        1 taggatatta ttataggcaa taactaacat caagcgataa cttaatacat ataaaaataa
       61 ataaacaatt aataaaaatt aaaacttcat tataaaacgg aaggatagtg aaaaaatgca
      121 actatataac acccccttta atacaaacaa acacttaatc tatttcttta catttactct
      181 agtattgaac tggatattca gtcttacacc tgcgttgctc ggaattacaa atacaatact
      241 tggagaaatc attttttatc ttgcatatac atcaccagct attgtaggtc tattttttat
      301 ttctacaatc tatccacaaa gtgcaaaaca agattttatt tatagatacc taagctttaa
      361 agaaatcgga ataaaatgga tactattaac aatattattt tttgctttaa cttttattac
      421 ttcgttaata atcggaaatt actttaatgt aaaaacttct gatatagatt ggatacacat
      481 agcagtgttt agaccttcta aaatagctta tatgctatta gcaagtttta tattgagtat
      541 acttagtcaa gaagctggat ggagaggata tgccattgac aaattattag ttagatttgg
      601 atttataggc tcttcaatta ttttagggct tgtttgtgga atctggtatc tagggtcgta
      661 ttttacacct aatcaaatac catataattt ggcacaatac tccctatttg atgctttttt
      721 atttatacca aacattgtac ttttaaactt tataattaat tttgtatata tcaatacaag
      781 tagaagcatt ttatcagctg gattagttca tatgatgtac tattttttca acattcaatt
      841 acttctacac taccctatta aattatgtgt aatagctcaa tatgtacaaa taatatttgg
      901 tttaatattt cttgtatata tgatttcttc taataaattt aaacagaagg taaattctga
      961 aattgaacag ataaagtcgg atgattttga atttgagtta gactggtaat tttaatatga
     1021 attataaatt aagataatct atgatttgat acgattacta cttaaatata atttactctc
     1081 tataatttat tgcaacatct ggaaaataat tgtatttcca caaacgcttg aagtatataa
     1141 aaacaaaata tatactgatt ataagtgaaa aggaggtcat attttcatgt ttaaaatagg
     1201 agaggtttca aaactaacac aaatttctat tcgtatgttg cgttattatg atgaacttgg
     1261 tattttaaaa cctgcaaaaa cagacaaata tacaggtcat agattatact cagttgaaca
     1321 gatttcaata ttacaaagaa ttgtattatt gagagattca aaatttagcg ttgcagaaat
     1381 agcaaatatc gtacataatt ggaatgatga atttgtaatt aaggaattga atagaaaaaa
     1441 gaatgaaata caaaaggaaa taaagcagga acaacaaaga ataaataaaa ttgataaatt
     1501 tatagaagct ataaactgtg ataaagatga aattcattac aatgttgtct ttaaaaagat
     1561 tccaagttat aaaatcatat cacttagaga gataattcca gactaccaat ctgaaggtat
     1621 actctgggaa aagctatcta aatttatcaa agaagaacat atagaagtat cacgtcaatc
     1681 caacaataac atagcttttt accatgatga agaagtcaaa gataatggtg tagatattga
     1741 agttggaatg gttgtaaaga agattggaaa gaacaaatct ggatttatat atcgtgagac
     1801 agaagaaatt gatatgatgg catgtactat ggtttatggt ccatatgaaa atatagctgg
     1861 tgcatatgaa tcgttctgtt attggttaga taaaaatagt gattatcaaa tatcaggtat
     1921 aaatagacaa atcggacata aaggtgaaca taatgaaata aatcctgaaa attatcttac
     1981 agaaattcaa atccccctta taaaagtcta atagattagt acttaaatac ttaagtacta
     2041 atcacccatt gacatcccaa aattttcatg atagtatcta aacgtgtatt aaacatgttt
     2101 aattttttta tggagaaact tttaagggga aaaattatga aagcagattc aacaaaggaa
     2161 caattaatta atgccacaat ccagttacta tcttcacata gagatgtttc aagcattacg
     2221 gctagagaaa ttgtagctaa agcaaatgtc aatttagcta tgattaatta ttattttaaa
     2281 tctaaagagg agttaattaa tatttctatt aaaaaatttt taaagcgtca tatggatgaa
     2341 tataaggcta cacatgatac taaaaattta gcacctaaac agcaattaag ggaaatacta
     2401 attgcatttt ttgattttat aggtgaacat agtcaattta taaagatttc tgtaccctat
     2461 atattgatac aggaagaaat tgtttatcca tttgagatac tacctttaat taaggctcac
     2521 tatgaaaatc agaataacaa aaaaactgaa gctgaataca gaactattgc gtatcaaata
     2581 acttcattta ttcagttgct ttttcttcgt tctaatgctt ttttcaagta tagtggtatt
     2641 gatattctta atattgaaca gagaaatggt ttaatagatt ttcaattaga tttattattg
     2701 gtagatatta caaaataata ctatattaat tttttatgta cattttttta ttttatggta
     2761 acgtttgaaa atattctcat tgactaaaaa tacttgcatt aaataagggg gaggaatttt
     2821 aatgtttttt acatttatag gagtaatatc agcaatttta ttgttgtgta caattatatg
     2881 tggtttatgg ataaaactta ataatcgtaa taatgactct aattctcact ttactttttc
     2941 aatactttca attgcttttt cactgttaat tgtggtggcc tttttagtaa gaaattaatg
     3001 tctttgttat gctgaggttt attattatag atttttatta ttgcatgatt tttactatat
     3061 tatagtattt ttattatatt acagggtctt atttattata gtgttttgtt gttacagcat
     3121 tttattatat tacagagtcc tatttattat aggattttta ttatattgta aaatcttatt
     3181 tattatagga ttttgttata ttacagactt ttattatatt gaaatctctt atttattgca
     3241 gtgtttctat tatattgcaa actcttattt attatggtgt tttgttattg caacatttct
     3301 attatattgt aaagtcttat ttattacagt tctttattat actacagacc tttattatta
     3361 cagcatttct attacattgt aaagtcttat ttattacagt tctttattac actacagact
     3421 tttattatta caatctctta tttattacag ttctttgcta tactacagac ctttattatt
     3481 acagcatttc tattacattg caaagtctta tttattacag ttctttatta tactacagac
     3541 ttttattatt acagcatttc tattac
//
LOCUS       DAEHWM010000180         3547 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.183, whole genome shotgun sequence.
ACCESSION   DAEHWM010000180 DAEHWM010000000
VERSION     DAEHWM010000180.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3547)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3547)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3547
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.183"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            100..1569
                     /locus_tag="KNP36_003664"
     CDS             100..1569
                     /locus_tag="KNP36_003664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003438615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanW family protein"
                     /protein_id="HBF0875489.1"
                     /translation="MSNVNKKLVIAIGAVALVVIIFIGIMCMQFKGEKIAKNTYVNGV
                     NIGKLTKSQAKQELAKKYKLENVDFNYNDKSWKVKSKDLNLSTDLDKTVENAYNLNRK
                     SAFFGNLSKTISANFGKKSNLVVAINYDKNKLKAEMEKIAKEIDVDVKDATLDISGEK
                     VKVIPDSDGLKMDISKSMENFDNQTKKGNYKNELVVKATPAKVKKEQLANIDTNLGTY
                     STTFKTSQINRSINIKLATDNISNVLLMPGETFSFNKHTGKRSKENGYKSAPVIMEGE
                     MEEDYGGGVCQVSSTLYNSVLYAGLEIVNVKNHTIPSSYVPKGRDATVADSGIDFLFK
                     NNLKHPVYIKNYVSGNQIVCNIYGSAEDKQNITISTKLDGVSQTTMKRVNDPTMPKGK
                     EKVDKSGRNAYSVSTYRTFNDANGKKIKTEKIANSYYPKKEGIILVGTMEPKPEEKPN
                     TDENKNNQNTNNQNPNNQQKPETPPTDNKPNETQPQPQA"
     gene            1634..2227
                     /locus_tag="KNP36_003665"
     CDS             1634..2227
                     /locus_tag="KNP36_003665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fis family transcriptional regulator"
                     /protein_id="HBF0875490.1"
                     /translation="MNLNNITNYVQSICENISNVLDVDVTLVTKDLTRIAGTGIFRGK
                     IGETISEKSVYSLVLKDGKSYVINKEIEENCNKCANRENCKELADICTPVKMGEHILG
                     ILGIAAFNEEQKEKILSKDKELTAFVRSMSDLISFKLDELYKQEVKTIDDLEREAIEN
                     AIKKYGSNTEGMKKVAEALNIGIATLYRKVKKFNIKS"
     gene            2358..>3547
                     /locus_tag="KNP36_003666"
     CDS             2358..>3547
                     /locus_tag="KNP36_003666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003419859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multiprotein complex assembly protein"
                     /protein_id="HBF0875491.1"
                     /translation="MEVSIILVKDIKQDIESMPRKILDISLIEDNKSDLTFFNIEEED
                     GDETLKALKQSYVTTNYKEETLLNLQGALNSKSDTTSKELKLESYKRYNNALDLAYKN
                     YITSAINMVNKALEINPKDIDILNLRGLLKLLKCDFAKSFESFYTALCYENNHISRKY
                     VNLISSEDFKTFLGRYNHSIRFINEELNYESIHILENIIEEEPELIEPYVILSLLYDK
                     LGNVKKREGYLDKLKELDKDNPVFEKNEEEKEDTSKKEEIKKVKRKKSILPYIIVGCV
                     LIGMGIYLIQSKKRIENLNNQISSKEEKLSETDKKLGETSKKLEKTNKELNEVKNKEP
                     EREITVADEEDLYYQALNLKKNKEYEKAIDNFKSVVSSGKTKKYISESIYQLAITNKL
                     LGNK"
BASE COUNT         1586 a          344 c          613 g         1004 t
ORIGIN      
        1 taatatataa ttaaaaagtt tttggggttt taaggcgcat tatgtagtaa tataataata
       61 gggatatata aataatttta ttgtaaggag aagtatggga tgagtaatgt gaacaaaaag
      121 ctagttatag ctattggagc tgtagcatta gtagtaataa tttttatagg cataatgtgc
      181 atgcaattta aaggggagaa aatagcaaaa aacacatatg ttaatggagt aaatattgga
      241 aaattaacta aatcacaagc aaaacaggaa ttagctaaaa aatacaaatt agagaatgtt
      301 gattttaatt acaatgataa aagctggaaa gtaaagagca aagatttaaa tttatctact
      361 gacctggata aaacagtaga aaacgcatat aatttaaata gaaagagtgc tttctttggc
      421 aatctatcaa aaactatttc agcaaatttt ggcaaaaaaa gcaacttagt agttgcgata
      481 aattatgata aaaataaatt aaaagcagaa atggaaaaga tagctaaaga aatagatgta
      541 gatgtaaaag atgctacact tgatataagt ggtgaaaaag tcaaggttat accagattct
      601 gatggtctta aaatggatat ttctaagagt atggagaatt ttgataatca aactaaaaaa
      661 ggtaactata aaaatgagtt agtagtaaaa gctactccag caaaagtaaa aaaagagcaa
      721 cttgctaata tagatacaaa tttaggtacg tattcaacaa catttaaaac ttctcaaata
      781 aatagaagta taaacataaa attagcaaca gataatataa gtaatgtatt acttatgcca
      841 ggagaaactt tctcatttaa taaacataca gggaaaagaa gtaaggaaaa tggatataaa
      901 agtgcacctg taataatgga aggtgagatg gaagaagatt atggtggagg agtttgtcaa
      961 gtttcatcta cgttatacaa ttctgtgcta tacgcaggtt tagaaattgt taatgtaaaa
     1021 aatcatacta taccatcaag ttatgttcca aaaggaagag atgcaactgt tgcagatagt
     1081 ggaatagatt tcttatttaa aaataatcta aagcatccag tttacataaa aaattacgtt
     1141 tcaggaaatc aaattgtttg caatatatat ggaagtgcag aagataaaca aaatataaca
     1201 atatcaacaa aattagatgg cgtttcacaa actacaatga aaagagttaa tgaccctaca
     1261 atgcctaaag gtaaagaaaa agtagacaaa agtggaagaa atgcatattc tgtatcaaca
     1321 tatagaacat ttaatgatgc aaatggtaaa aaaattaaaa ctgaaaaaat agctaattca
     1381 tattatccta agaaggaagg tattatatta gttgggacta tggaaccaaa accagaggaa
     1441 aaaccaaata cagacgaaaa taagaataat caaaatacaa acaatcaaaa cccaaataat
     1501 caacaaaaac cagaaacacc accaactgat aataagccta atgagacaca accacaaccg
     1561 caagcttaaa gttctcaaga ataggattta tgtagagtaa taaaaaatat aaatctaaat
     1621 aggagggatt actttgaatt taaataatat aacgaattac gttcaaagta tttgcgagaa
     1681 tatttctaat gtcttggatg tagatgttac tttagttaca aaagatttaa ctaggatagc
     1741 aggtacagga atattcagag gtaaaatagg agagacaata tcagagaagt cagtgtactc
     1801 tcttgtttta aaagatggga aatcctatgt tataaataaa gaaatagaag agaactgtaa
     1861 taaatgtgca aatagagaaa attgtaaaga gttagctgat atatgtactc ccgttaaaat
     1921 gggagagcat atacttggaa tcttgggtat agctgcgttt aatgaagaac aaaaagaaaa
     1981 gatactttca aaagataagg agttaactgc ttttgtaagg agtatgtctg atttaatatc
     2041 ttttaaacta gatgaacttt ataaacaaga agttaagact atagatgacc ttgagaggga
     2101 agctatagaa aatgccataa agaaatatgg aagtaataca gaaggtatga aaaaagtagc
     2161 tgaggcatta aatataggta tagctacact ctatagaaaa gtaaaaaaat tcaacattaa
     2221 aagttaatag tattgaaaaa gaggtaacct ttttatgaaa agaagaggat tacctttttt
     2281 attatgagaa tggtggaaaa atatgtatag ttttgacttg acatattaaa tatgttatct
     2341 taaatatata ttttagagtg gaggtgagta ttattttagt taaagatata aaacaagaca
     2401 tagaaagcat gcctagaaaa attttagata tatctttgat agaagataat aaaagtgatt
     2461 tgactttttt taatatagaa gaagaagacg gtgatgaaac attaaaagca ttaaaacaga
     2521 gttatgtgac tacaaattat aaagaagaaa ctctattaaa cttgcaagga gctttaaatt
     2581 caaagtcaga tacaacgtct aaggagttaa aattagaatc atataaaaga tataacaatg
     2641 cattggattt agcatataaa aattatataa ctagtgccat taatatggtt aataaagctc
     2701 tggagataaa tcctaaagac attgatatac taaatcttag aggtctttta aaattattaa
     2761 aatgtgattt tgctaaatca tttgagagtt tttatactgc tttatgttat gaaaataatc
     2821 atatatctag aaaatatgta aatctaattt catctgaaga ttttaaaact tttttaggaa
     2881 gatacaatca ttctataaga tttataaatg aagaattaaa ttatgagtca atacatattt
     2941 tagagaacat aattgaagaa gaacctgaac taatagagcc atatgtaatt ttatctttgt
     3001 tatatgataa actaggtaat gtaaaaaaga gagaaggata tttagacaaa cttaaagagc
     3061 tagataaaga taatcctgta tttgaaaaaa atgaagaaga aaaagaagat acaagtaaaa
     3121 aggaagaaat aaaaaaagta aaaagaaaga aaagtatttt gccatatatt atagttggct
     3181 gtgttttaat aggtatgggg atatatttga ttcaaagcaa aaagagaata gaaaacttga
     3241 ataaccaaat aagtagtaaa gaggaaaagt taagtgaaac tgataaaaag ttaggagaaa
     3301 cgagtaaaaa attagaaaaa acgaataagg aattaaatga ggttaaaaat aaagaaccag
     3361 aaagagagat aactgtagct gatgaggaag atttatatta tcaagctcta aatttaaaga
     3421 aaaacaaaga atatgaaaaa gccatagata attttaaaag tgtagtttct tctggtaaaa
     3481 ctaaaaaata tatttctgag tcaatatatc aattagcaat aacaaataaa ttattaggaa
     3541 ataagga
//
LOCUS       DAEHWM010000181         3388 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.184, whole genome shotgun sequence.
ACCESSION   DAEHWM010000181 DAEHWM010000000
VERSION     DAEHWM010000181.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3388)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3388)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3388
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.184"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1102
                     /locus_tag="KNP36_003667"
     CDS             <1..1102
                     /locus_tag="KNP36_003667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875492.1"
                     /translation="KTIKGDSNELDHININFGYALNGYINSYYTINGSNKTKKTELIK
                     LQKDSKNTNNLIDVSSGSDLIAHVGFEMNEESKDINFVIDEKKEDLEKGVFPSEGSDK
                     EIEYEKLDMNNFTRTRYKVDKSTDDYYAKILASKRYKKYLYVSVLYATSDSSENNKEY
                     SSTIDIIKINPENKKIKTIKSINLSNYFSEKYQNIENIGVSYASKYEDKMYILVNVLN
                     TNIGDNSNSKFHLLEYNLEENKESIMELKTDSKMALAKAKLEANKLYMVMSNDYDNSS
                     ITELNLLTYNILDKSLDEDKYVLDNREKRGIRSIEIDSNKIVAYTSRLNSILSWDDKF
                     MLYIINKNSKEIVYEGELQFNSSNSMLEFEIK"
     gene            1111..1923
                     /locus_tag="KNP36_003668"
     CDS             1111..1923
                     /locus_tag="KNP36_003668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875493.1"
                     /translation="MKDLIRLFEFELKRNIKNYIFIIICCCSFVILNIVKNLNDYNYI
                     IENAVKSEQLTKIGNTIETVNVTGFSSFRNIMGSTESWFMFGIIACICYAFFIWYRDF
                     NGRSKSIYTLIMLPKNRINIYISKLLNILFLVYSYTVVLTISLFIASKLLPRHMLGNV
                     TNYGFVQETIYELKMLLPYSFEILFVEYIFLLIGFVSVVFTSILINKSIYKVSTLISF
                     LFLVIEILVFIISIEFIIPYEYSDVFTVLYSSINIFVCSLISNKLLKQKIDF"
     gene            1934..3202
                     /locus_tag="KNP36_003669"
     CDS             1934..3202
                     /locus_tag="KNP36_003669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875494.1"
                     /translation="MKAKNIGKYTICFIIVCFLMITMTLILSYFNKDKLSVKTLKGNV
                     KDIGRVSVVYTPNISKFSYEEVIISKNGVRNNTNPKSRIRNDYLNIDKKYSDFVNDKG
                     KEFIYKDDLNIGEAYTSVKSDLVQGMNALNDCIKVSNKNLKSGVEENFDINLNKSDFK
                     ENSWKTLFNKIYKGNLYMVISETNISGSKVNNICILKIDIKNKSYKLLNRFNLGLQNG
                     EQQNINEIKFSIGSKLYLEIVNNKSKNGYIEGHDSYSNFIIYDIEDNTFNISNKFMDN
                     LNKEKNANPKEIGLLSKTKLDYMVKNNKLNLIVTDMSNSITNLVYDINSNEIKLEDYE
                     ILDLKVDYNEASSGVRKVKLLDDKIYSISGIKNSISGELKGFKGIIDVVGTKPVKFQV
                     FDMKLKKNIYEAELINGDISLQEKLFFVAN"
BASE COUNT         1454 a          266 c          511 g         1157 t
ORIGIN      
        1 aaaaactata aaaggtgact ctaatgaatt agaccatata aacataaatt ttggatatgc
       61 tttgaatgga tatataaatt catattatac aataaatgga agcaacaaaa ccaaaaagac
      121 tgaattaata aaactacaaa aggatagtaa gaacacaaat aatttaattg atgtatctag
      181 tggttcagat ttaattgctc atgttggatt tgaaatgaat gaggagtcaa aagatataaa
      241 ctttgtgata gatgagaaaa aagaagattt agaaaaaggt gtatttccat cagaaggtag
      301 tgataaagaa attgaatatg aaaaattaga tatgaataat tttacaagga caagatataa
      361 agtagataaa agtacagatg attattatgc aaagatacta gcatcaaaaa gatataaaaa
      421 atacttatat gtatctgtac tttatgctac aagtgattca tcagaaaata acaaagaata
      481 ttcaagtact atagatataa taaaaattaa tccagaaaat aaaaaaatca agactataaa
      541 aagtataaat ttaagtaatt atttttccga aaaataccaa aacatagaga acataggtgt
      601 aagttatgct agcaaatatg aggataagat gtatatttta gtaaatgtac taaatacaaa
      661 cataggtgat aatagtaatt ctaaatttca tttacttgag tataatcttg aagaaaataa
      721 ggaaagcata atggaattaa aaactgatag caaaatggct ttagcaaaag caaagttaga
      781 agctaataaa ttatatatgg taatgtcgaa tgattatgat aatagttcaa ttacagagtt
      841 aaatttactt acctataata tattagataa aagcttagat gaagataaat atgttttaga
      901 taatagagaa aaaagaggaa ttagaagtat tgaaattgat tcaaataaaa tcgttgcata
      961 tacatcaagg ctaaactcta tattatcttg ggatgataaa tttatgctat atataataaa
     1021 taaaaattct aaggaaattg tatatgaagg agaattacaa tttaacagtt caaatagtat
     1081 gttagaattt gaaataaagt aggtgagttg atgaaagatt taataagatt attcgaattt
     1141 gaattaaaaa gaaatataaa gaattatata tttataataa tttgttgttg ttcttttgta
     1201 attttaaaca tagtaaaaaa tttaaatgac tataattaca taatagaaaa tgcagttaaa
     1261 agtgaacagt taacaaaaat cggaaatacg atagaaacgg taaatgttac aggtttctca
     1321 agctttagaa atataatggg ttctacagaa tcgtggttta tgtttggtat aattgcatgt
     1381 atttgctatg ctttttttat ttggtataga gactttaatg gtagaagtaa atctatatat
     1441 acacttataa tgctacctaa aaatagaatc aatatttata tatctaaatt attaaatata
     1501 ttatttctag tgtatagcta tacagtagta cttacaatat ctttgtttat tgcaagtaag
     1561 ttgttgccta gacatatgct tggtaatgtc acaaactatg gttttgtaca agaaacaata
     1621 tatgagttaa aaatgttact tccatatagc tttgaaatac tatttgtaga gtatatattt
     1681 ttattgatag gatttgtatc tgtagtattt acatcaattc ttataaataa atctatttat
     1741 aaagtaagca ctttaataag ttttctattt ttagttatag aaattttagt gtttataatt
     1801 tctatagaat ttattatacc ttacgaatac agtgatgtat ttactgttct atattcaagt
     1861 ataaacatat ttgtatgtag tcttatatct aataaacttt tgaagcaaaa gattgacttt
     1921 taggagggat attatgaaag caaaaaatat aggaaaatat acaatatgtt ttataatagt
     1981 atgtttttta atgattacta tgaccttaat attgagttat tttaataagg ataaactatc
     2041 tgtaaaaact ttaaaaggca atgtaaaaga tatagggaga gtaagtgtag tatatacacc
     2101 taatataagc aaattttctt atgaggaggt aattataagt aaaaatggag taagaaataa
     2161 tacaaaccca aaatcaagaa ttagaaatga ttatttaaat attgacaaaa aatacagtga
     2221 ctttgttaat gataaaggaa aagaatttat atataaagat gatttgaata taggagaagc
     2281 gtatacctct gttaagtctg atttagtaca aggaatgaat gctttaaatg attgtataaa
     2341 ggtttcaaat aaaaatttaa aaagtggggt agaagaaaat tttgatatta atttaaataa
     2401 gtctgatttt aaagaaaata gttggaaaac cttatttaac aaaatatata aaggtaattt
     2461 atatatggta attagtgaaa ctaatatttc aggttctaaa gtcaataata tttgtatatt
     2521 aaagatagat ataaaaaata agtcttataa attattaaat agatttaatt taggattaca
     2581 gaatggagaa caacaaaata tcaatgaaat taaattttct attggaagta aattatactt
     2641 agaaatagta aataataaaa gtaaaaatgg atatattgaa ggacatgata gttactctaa
     2701 ctttattata tatgatatag aagataacac ttttaatata agtaataaat ttatggataa
     2761 tctaaacaaa gaaaagaatg caaatccaaa ggagattggc ttattaagta aaactaagct
     2821 agattatatg gtaaaaaaca ataaattgaa tcttatagtt acggatatga gtaattccat
     2881 aactaatctt gtttatgata ttaattctaa tgagattaaa ttagaagatt atgagatact
     2941 tgatttaaaa gtagattata atgaagcatc atctggagtt aggaaagtta agctactgga
     3001 tgataagata tattctattt caggtattaa gaacagtata tcaggagaat taaaaggatt
     3061 taaagggatt attgatgtag tcggaactaa gccagtaaaa tttcaagtat ttgatatgaa
     3121 acttaaaaag aatatttatg aagctgagct aataaatgga gatataagtt tacaagaaaa
     3181 gttatttttt gttgcaaatt aagtgttaga attaatttta gaactttaaa cttttatatg
     3241 tatcacagat aagtataagt aagggagtgt ctcaaaataa actttttagc tcatgagaca
     3301 ctttttttat atgaaatcaa atatattttc attgtttaga tttattttga taatgaaaaa
     3361 aagattatct ttattttaag aaagacat
//
LOCUS       DAEHWM010000182         3368 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.185, whole genome shotgun sequence.
ACCESSION   DAEHWM010000182 DAEHWM010000000
VERSION     DAEHWM010000182.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3368)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3368)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3368
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.185"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     misc_binding    439..649
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            875..1690
                     /locus_tag="KNP36_003670"
     CDS             875..1690
                     /locus_tag="KNP36_003670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HBF0875495.1"
                     /translation="MKVFKKLLSLGLVLGLTLSLVGCSGGGEKTKLEQIKDNGKLVVG
                     TSAEFPPFEFHKVVDGKDSIKGFDIMLAEEFAKELGVKVEIKDMSFDGLIGALNADQV
                     DIVLAGMSPTPEREKSVDFSELYYLSRNAVIVKDADIDKVKTEDDLKKLRVGVQAGSI
                     QEEYVVNTLKMTTTKSLKAIPDLITELKNGNIDAVVTNEAVSLINVKKYDGIKMANTE
                     VGKDVTEGMAAAIKKSDNNKDFIELLNKKIKELQDGKKIEEFLNEASTEAASN"
     gene            1718..2395
                     /locus_tag="KNP36_003671"
     CDS             1718..2395
                     /locus_tag="KNP36_003671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888558.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HBF0875496.1"
                     /translation="MSLDFSFLSRFGTSFLEGTGVTVSISLVALCFGFIIGIIICMAK
                     ISKSKVLRAISSIYIEVLRGTPLLVQIYIVWFGLPQLGIRFPMLFGIPSEFIASAFAL
                     SVNSGAYVAEILRSGIQSVDNGQMEASRSLGLNYWSTMRYIIIPQAIKNILPSLANEF
                     ITLVKESSIISVIGVVEIMRTADIVKNAAFRALEPLIVAAAIYFVITFTLSRLVGLLE
                     KKLSVSN"
     gene            2454..3176
                     /locus_tag="KNP36_003672"
     CDS             2454..3176
                     /locus_tag="KNP36_003672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004398740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HBF0875497.1"
                     /translation="MITIKNLSKSFGDLNVLKNIDLEIAKGEIMVIVGPSGSGKSTLL
                     RCMNLLEIPTGGEIIFEGKNLVDKKTNIDEVRQNIGMVFQNFNLFPHKTILDNITLAP
                     IKLKKMTKEEAEKKAEILLSRVGLLDKKDSYPSQLSGGQKQRIAIARALAMEPDMMLF
                     DEPTSALDPEMVNEVLDVIKELAKEGMTMAIVTHEMGFAKEVADRVIFIDGGSILEDN
                     TPEEVFGNPKHERTKAFLAKVL"
BASE COUNT         1356 a          333 c          631 g         1048 t
ORIGIN      
        1 atactattta gtattattaa agaaaaagca acagtgtgaa agatattatt tagtgtaatt
       61 taagaaaaag caacaatgtg aaagatatta tttagtatta ttaaagaaag ggcaacagtg
      121 tgaaagatac tatttagtat tattaaagaa aaagcaacag tgtgaaagat attatttagt
      181 gtaatttaag aaaagcaaca atgtgaaaga tattatttag tattgtttaa gaaaaagcaa
      241 caatgtgaaa gatattattt agtattattt aagaaatatc taaaaatatg aaatatacta
      301 tttataatta caaaactaat atcaataaat ataaacagta gtatttagat aatttacaag
      361 taaaaattat taaaaaaata aaaaacttat tgacaaaaat attataagga agtacaattg
      421 tattaacaat ttaaggaaac aaatccaatg atagagaaag tagcatatat ggatttacag
      481 cgagttaggg gttggtgtaa gcctagcaat gaagtctatg tgaagagagc tctggaggag
      541 attatcagaa actttagtat gataattggt ttacccgcct taagggattg agaggataag
      601 tacttactta tcaaaaagag tggtaacgcg gatataattc gtctcttagc tgtaaagcta
      661 agggactttt ttgatttaaa aataaaagta tccatacagc ttaaatgcta acagtcacaa
      721 attttgaaag taatataagt atttatcaat aagagtggta acgcggtaaa gtcgtctctt
      781 agtcattaaa gactgagaga ctttttttgt aactcgaaac atttaagtat taaaatctga
      841 gggaaattat aattaaaaga gaggggtagt taaaatgaaa gtatttaaaa aattattaag
      901 tttaggatta gtattaggat tgacattatc gctagtagga tgtagtggtg gaggagaaaa
      961 aacaaagtta gaacaaataa aagacaatgg aaaattagtt gttggtacta gtgcagaatt
     1021 tcctccattt gaatttcata aggtagtaga tggaaaagat tcaataaaag gattcgatat
     1081 aatgttggct gaagaatttg caaaagagct tggtgtaaag gttgaaatta aggatatgtc
     1141 atttgatgga ttaataggtg ctttaaatgc agaccaagtt gatattgttc ttgcaggtat
     1201 gtctccaaca ccagagagag aaaagagtgt tgatttttca gaattatatt atttaagtag
     1261 aaatgcagtt atagttaaag atgcagatat agacaaagta aaaactgaag atgatttaaa
     1321 gaaacttaga gttggagttc aagcaggaag tatccaagaa gaatatgtag ttaacacttt
     1381 aaaaatgaca actacaaaat ctttgaaagc aatacctgat ttaattacag aattaaaaaa
     1441 tggaaacata gatgcagttg ttactaatga agcagtttct ttaataaatg ttaaaaaata
     1501 tgatggaata aaaatggcaa atactgaagt tgggaaagat gtaacagaag gtatggcagc
     1561 agcaatcaaa aaatctgaca ataacaaaga ttttatagaa ttattaaaca aaaagataaa
     1621 agaattacaa gatggcaaga agatagaaga atttttaaat gaagcatcta ctgaagctgc
     1681 ttcaaattag taagaaagtt atgtgggaga tgaaattatg agtttagatt ttagtttttt
     1741 aagtagattt gggacttctt ttttggaagg aacaggtgtg acagtatcaa tttctcttgt
     1801 ggcattatgc tttggattta taataggtat aattatctgt atggcaaaaa tatcaaagag
     1861 caaggtatta agagcaatat catcaatcta tattgaggtt ttaagaggga caccattatt
     1921 agtacagata tatatagtat ggtttggttt acctcaatta ggaataagat tccctatgtt
     1981 gtttggtata ccaagtgaat ttatagctag tgcatttgca ttatcagtaa actctggtgc
     2041 atacgtggca gagatactta gatcaggtat acaatcagtt gataatggac aaatggaagc
     2101 aagtagatca ttaggattaa attattggtc aactatgaga tatataataa tacctcaagc
     2161 tataaaaaat atattacctt cattagcaaa tgagtttatt acacttgtaa aagaatcttc
     2221 aataatatct gtaataggag ttgttgagat aatgcgtact gctgatatag taaaaaatgc
     2281 agcatttaga gcattagagc cattaatagt agcagcagca atttactttg ttataacatt
     2341 tactctatca agattagttg gattattaga aaagaaacta tctgtgtcta actagatgag
     2401 agcatgttta gcatttaggg aaaacataga atagtaaaaa ggaaagtgat aatatgatta
     2461 caataaaaaa tttaagtaaa tcttttggag atttaaatgt attaaaaaat atagacttag
     2521 aaatcgctaa aggcgaaata atggttatag taggtccaag tggttctggt aaaagtacac
     2581 ttcttagatg tatgaattta ctagaaatac ctacaggtgg agaaataata tttgaaggaa
     2641 aaaatttggt cgataaaaaa actaatattg atgaggttag acaaaatata ggtatggtgt
     2701 ttcagaactt taatttattc ccacataaga ctattttaga taatataaca ttagcaccaa
     2761 ttaaattaaa aaagatgact aaggaagaag cagaaaaaaa agcagaaatt ttgttgagta
     2821 gagttggtct tttagataaa aaagattcat atccatcaca attatctgga ggacaaaagc
     2881 aaagaatagc aatagctaga gcacttgcta tggaaccaga tatgatgttg tttgatgagc
     2941 caacatctgc tcttgaccca gaaatggtaa acgaagtttt ggatgttata aaagaacttg
     3001 ctaaagaagg tatgacaatg gcaattgtaa ctcatgagat gggatttgct aaggaagttg
     3061 cagatagagt tatttttata gatggaggaa gtatacttga agataatact ccagaagaag
     3121 ttttcggaaa tccaaaacat gaaagaacaa aagcattttt agcaaaagtg ctataatata
     3181 taaaaaggat gttattgata ttagaaattc aatacatcct tttttagtga tggttaatat
     3241 taattttaaa attaaagtta tattaatatt aactttattt ttacgatttt ttgcagaaaa
     3301 aaaagagctc ggggtaagct ctttttttcc accgaattaa tttccgttac taatccgatt
     3361 tttaataa
//
LOCUS       DAEHWM010000183         3168 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.186, whole genome shotgun sequence.
ACCESSION   DAEHWM010000183 DAEHWM010000000
VERSION     DAEHWM010000183.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3168)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.186"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(145..402)
                     /locus_tag="KNP36_003673"
     CDS             complement(145..402)
                     /locus_tag="KNP36_003673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HBF0875498.1"
                     /translation="MKIKVEDIPVQFHAMVEIIGIDKFIEVAKLYGGTNTYIPTYKGL
                     FRYARNRDIVKQFNGVNHNELAIRYNMCVSNIKRILNENSV"
     gene            982..1203
                     /locus_tag="KNP36_003674"
     CDS             982..1203
                     /locus_tag="KNP36_003674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1659 domain-containing protein"
                     /protein_id="HBF0875499.1"
                     /translation="MEVVSTKNLSSIKLKLDAGFDDKGKAVVKSKSFANVKAEALNED
                     VYAVAEAIASLQENPIVDILKLDSTSLSK"
     gene            2062..2292
                     /locus_tag="KNP36_003675"
     CDS             2062..2292
                     /locus_tag="KNP36_003675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2922 domain-containing protein"
                     /protein_id="HBF0875500.1"
                     /translation="MEIKKKLVMSFKNVKDKQVSFSIENPKDDLTEENIKSVMDLIVS
                     KNIFSVGGFDLASVVEAKVVETNTTPYDLVIE"
     gene            2305..2454
                     /locus_tag="KNP36_003676"
     CDS             2305..2454
                     /locus_tag="KNP36_003676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvrJ family protein"
                     /protein_id="HBF0875501.1"
                     /translation="MDDSLQLLITNVGFPIALSMYLLVRIEGKLNTLSNSIDTLSKNI
                     LIFKK"
     gene            2711..3148
                     /locus_tag="KNP36_003677"
     CDS             2711..3148
                     /locus_tag="KNP36_003677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
                     /protein_id="HBF0875502.1"
                     /translation="MKIHVEQGINCDDIEITIKCSALDNNIEKIISLLSIPLLDIKGK
                     KSGEIYKLNVCDILYFETVGNKTFAYYEDDVFEIDLKIYKLSKLLANTSFSRISKSMI
                     LNMDYIKSIKVISHNRMQATLKNNEKVIINRRYIKNIKEKLNI"
BASE COUNT         1302 a          402 c          351 g         1113 t
ORIGIN      
        1 ttatagaata tacaatgtat ttaaattaat aagtagtaaa tttagttaat ttgtctaaaa
       61 aaactttata aaacatcttc tttgtcttta ctcttacgtt taacaaggct attttcatta
      121 tgtttaaaca ttattttatt atatttaaac actattttca ttgagtattc gcttaatatt
      181 gcttacacac atattatatc taatagccaa ttcattgtgg ttgactccat taaattgttt
      241 tactatatcc ctatttctag catatctaaa aagcccctta tacgtaggta tataagtatt
      301 tgttcctcca tacaacttgg caacctctat gaacttatca attccgatta tttctaccat
      361 tgcatgaaat tgaactggta tatcctccac ttttatcttc ataagttaca cctcctttaa
      421 gatattttta tagacttaac aaagttttta tttaatacat tattgactaa actatattta
      481 ttagttttat tgaatctaat aaaaaatttc ttagctttaa aattaatttt tgtattaact
      541 tcaataaaat ttctcataac ttataacttt gttagcttta ataaagattt taatggttta
      601 aaagtaaaat gttaatattg gacttttaac ttttttattt acagattaaa tttaataaaa
      661 tttttaacat aagctttaac atttaattta acataaactt tagtacctaa catttaactc
      721 tacacatatg aaaatccata caaaactatc tcaactaagc atgaatatat acaaatacta
      781 tttcaaaaca ctaagaacat atcttcacaa ataacttgta aactttttca tcagcaaaaa
      841 agtaaaattt ttcctataaa aatttacaca aaaaatcttt agaaattact gtttaactcc
      901 gatattatct tagatgatag tattatagct aacaaagaaa gtcgacaaat ctttgaaatt
      961 aaatttttag gaggtaattt tatggaagtt gtttcaacaa aaaatttatc tagtataaaa
     1021 ctaaaattgg atgctggttt tgatgataag ggtaaggcag ttgttaaaag taaatcattt
     1081 gcaaatgtaa aagcagaggc attaaatgaa gatgtttatg ctgttgcaga agcaatagca
     1141 agtcttcaag agaaccctat tgtagatatt ttaaaattag atagtacatc actatctaaa
     1201 tagtgtcttt taaacgtact ctgctttaca aattaaaaaa ttaactcttt atataaaaga
     1261 ttaagttata taatgcactt aatacgctat agatttggca gattataact tcaattttgg
     1321 ttataacttt aatatattaa cgctttgaaa aattaatata ttaaacgtat ttcaacttaa
     1381 acatgttagc tattttagat gctaccctac tttaatctaa ttaattgaaa taaattaaat
     1441 attttctata tcagcaataa ctagagtcaa caattaaaat actaatattg acaattgaaa
     1501 cactgatact aacaagcaaa acactaatat tgacaattga aatactaata ctaacaagca
     1561 aaacattaat attgacaatt gaaatactaa tactaacaag caaaacacta atattgacaa
     1621 ttgaaatact aatactaaca agcaaaacac taatattgac aattgaaaca ctgatactaa
     1681 caaacaaaac actaatattg acaattgaaa tactaatact aacaagcaaa acactaatat
     1741 tgacaattga aatattaata ctaacaagca agacactaat attgacaatt gaaatattaa
     1801 tactaacaag caaaacacta atattgacaa ttgaaatatt aatactaaca agcaaaacac
     1861 taatattgac aattgaaaca ctgatactaa caagcaagac actaatattg acaattgaaa
     1921 tattaatact aacaagcaaa acattaatat tgacaattga aatattaata ctaacaagca
     1981 aaacattaat attgataatt aaaataccaa tattaacaag caaacaatta aaatataaat
     2041 tattatatcg gaggtaatta tatggaaatt aagaaaaaat tagtcatgag ctttaaaaat
     2101 gtaaaggata aacaagtttc tttttctata gaaaatccaa aggatgattt aactgaagaa
     2161 aatataaaat ctgtcatgga tttgatagta tctaaaaata ttttttcggt tggaggattt
     2221 gacctagctt ctgttgttga agccaaggtt gtggaaacaa ataccactcc ttatgactta
     2281 gttatagaat agggggctaa ttttatggat gatagtttac aactgttaat aaccaatgtt
     2341 ggttttccta tagctctatc catgtacttg ttggttagaa ttgagggtaa attaaatact
     2401 ttatcaaaca gtattgatac attatccaaa aatattttga tatttaagaa gtaatttgac
     2461 aatatatgta agtcataaaa taggtctatt tgtaaaataa ttagacatat tctatgtgaa
     2521 atactaggat atttggataa tttatccaaa tatccatagt atttttttga attttaccac
     2581 ctcaaatttg aatttcactg ttttattttt gaatttcact atgcttaatt tgaaatttag
     2641 aacgcatcta gttggactca ataagatata atgctattct aatgacagta ataaaatgag
     2701 gtgatgatta atgaaaatac atgtcgaaca aggtattaat tgtgatgata ttgaaataac
     2761 cataaaatgt tctgctctag ataataacat tgaaaaaata atttcattat tgagtatacc
     2821 gttacttgat ataaaaggta aaaaatcagg agagatttat aaactcaatg tctgtgatat
     2881 tttatacttt gagacagttg gaaataaaac atttgcttat tatgaagatg atgtatttga
     2941 aattgattta aaaatatata aattatcaaa attattagct aatacatctt tctcacgaat
     3001 atctaaatcc atgattttaa atatggacta cataaaaagt ataaaagtaa tatcacataa
     3061 tcgcatgcaa gctactttaa aaaacaacga aaaagttatt ataaatcgtc gttatataaa
     3121 aaatattaaa gaaaagctaa acatttaata aaaatctaaa gtaattta
//
LOCUS       DAEHWM010000184         2999 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.187, whole genome shotgun sequence.
ACCESSION   DAEHWM010000184 DAEHWM010000000
VERSION     DAEHWM010000184.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2999)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.187"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            68..958
                     /locus_tag="KNP36_003678"
     CDS             68..958
                     /locus_tag="KNP36_003678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0875503.1"
                     /translation="MAKLTLEHIKGNTYYIPLPTIVGVYVDGKDAILIDSGNNKDTAR
                     QVLRLLEEHNLNPKLIINTHSNADHIGGNAYLKNQTKCKIATTKIEGYFTENPILESA
                     FLYGGYPSKALKNKFLLAKESEVDYIIPSNGKIVDTELEAISLPGHYFEMIGVRTPDN
                     VLFVADSLTPENIITKYHFFFLLDIDSQFKTLEKLRMLEADFFVPSHSVKTTDIKSLI
                     NINKKKMEEIIDNIKKVCYEPVMIDEVIEKMCDLYNVKLDANQYVLVGSTIRSYITYL
                     YENNMVEYIFDGGKMMIKAV"
     gene            1176..2930
                     /locus_tag="KNP36_003679"
     CDS             1176..2930
                     /locus_tag="KNP36_003679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein Cwp23"
                     /protein_id="HBF0875504.1"
                     /translation="MYIMNKKFKKFSKKLSILILVLIMFLFNNLTANAQIKEDSIIGI
                     DRYETAGLIADRQTYDTVILVNGDKNLSDGLSSSGLAGAINAPILLTKKSEIPKATLN
                     RLDNKSLNVVKKVYIIGGYNTIENSVEKDIKRKGIQVERINGNNRIETSYNVAKKINE
                     VSSVKEVMLTNGFVGEADAMSIAPVVAKNKGAIILTDGKSVPFKTESLNVYAIGGKSA
                     INEDLVNETKATRIGGNDRFETNKKVMEKFYNGATDFYITNGYQLVDALTLSPLAKEK
                     PIVLVADGSNKGILKGAKSITKVGGIDANIYKQCLDMIKYNNMDMTPNILKHLTSVEG
                     NEVSEILIESDNLGVVVEKTNTNKFEFDYVSVTNEKNCTFSVYKENSSNNIKNGKLVV
                     SAKKKIDKKDSDLQDMNGDNMINANKDRMVNVIKIGVPDKMYSNFKVDVESGSVELYN
                     IKGGATVDVNDGIANIVDNNVTNPFNINTNSGISGVTAETISSEIKFRANNGIVNVTA
                     TNINGNISLFGSDNKGTFDGIFKLNLKKEPSNLHLKLIGNGINKLPEGWSKDYILGNG
                     QPIIEVKNNGINNISIGE"
BASE COUNT         1250 a          272 c          521 g          956 t
ORIGIN      
        1 caatttgatt ggaattttca gaaaattaat gctataatta aaagtaaatt taaagggagg
       61 ttataaaatg gctaaattaa ctctagaaca tataaaagga aatacatatt atattccact
      121 ccctacaata gtaggtgtat acgtagatgg taaggatgca attttaattg acagtggaaa
      181 taataaggat acagctagac aagttttaag attattagaa gaacataatt taaatcctaa
      241 attaataata aacactcatt caaatgcaga ccatatagga ggaaatgcat atttgaagaa
      301 tcaaacaaaa tgcaagattg ctacgactaa aattgaagga tattttacag aaaatccaat
      361 attagaatca gcatttttat atggtggcta tccaagtaaa gcactgaaga ataaattttt
      421 attagcaaag gaaagtgaag ttgattatat tatcccttca aatggcaaaa ttgtagatac
      481 agaacttgaa gcgatttctc ttccaggtca ttattttgaa atgattggtg ttagaactcc
      541 agataatgtt ttgtttgttg cagatagtct tacaccagag aatataatta ctaaatatca
      601 ttttttcttc ctactggata tagattcaca gtttaagaca ctagaaaaat tgagaatgtt
      661 agaggctgat ttctttgttc caagtcactc tgtcaaaact acagatataa aaagtttaat
      721 taatattaat aagaagaaga tggaagaaat aatagataat attaaaaagg tttgttatga
      781 gccagttatg attgatgaag ttattgaaaa aatgtgtgat ttgtacaatg tcaagcttga
      841 tgctaatcaa tatgtgttgg ttggaagtac aatacgttct tatataactt atttatatga
      901 gaataatatg gttgaatata tatttgatgg tggtaagatg atgataaaag ctgtgtaaat
      961 agtaataatt ttcaaattat atgatgaaat tgttttagta tgactgttat ttgaaaagta
     1021 atataaaaaa atttatataa ataagctaag atgattgata taaagttact gataatttta
     1081 aggtaatata tacgttacta taatattatg ttattatttg taaataaggg gataatttat
     1141 aagcaaatta aagaccttaa tttacaggag gaatagtgta tattatgaat aaaaaattca
     1201 aaaaattcag taaaaaacta agtatattaa ttttagtttt gattatgttt ctttttaata
     1261 atttaactgc aaatgcacag attaaagaag attcaataat aggaattgat agatatgaaa
     1321 cagcaggact tatagcagat agacaaactt atgatactgt aatattagtt aatggagata
     1381 aaaatttatc tgatgggctt tcatcaagtg gattagctgg agctattaac gcaccaatac
     1441 ttttgactaa aaaaagtgaa ataccaaaag ctactttaaa tagactagat aataagagtt
     1501 taaatgttgt aaaaaaagta tatataattg gtggttataa tactattgaa aattcagtag
     1561 aaaaagatat aaaaagaaaa ggtattcaag tggaaagaat aaatggtaac aatagaattg
     1621 aaactagtta taatgtagct aaaaaaataa atgaagtaag tagtgtaaaa gaggtaatgc
     1681 ttacaaatgg atttgtagga gaggctgatg ctatgagtat agcacctgta gttgcaaaaa
     1741 ataaaggagc tataatactt acagatggga aatcagttcc atttaagact gaaagtttaa
     1801 atgtttacgc tataggtggc aaatctgcga taaatgagga tttagtaaat gaaactaaag
     1861 caactagaat cggaggaaat gatagatttg agaccaataa aaaggtaatg gaaaagtttt
     1921 ataatggagc gacagatttt tatataacaa atggatatca attagtagat gcactaacat
     1981 tatctccttt agccaaagaa aaaccaatcg ttttagttgc tgatggaagt aataaaggta
     2041 ttttaaaagg agctaaaagt ataacaaaag ttggaggtat tgatgccaat atatataaac
     2101 agtgtttaga tatgattaaa tataataata tggatatgac tccaaatatt ttaaaacact
     2161 taacttcagt tgaaggaaat gaagtttctg aaatacttat agaatcagat aatttaggtg
     2221 tggttgttga aaagacgaat accaataaat ttgagtttga ttacgtaagt gtaactaatg
     2281 aaaaaaattg tactttttct gtatataaag aaaattcttc taataatata aaaaatggaa
     2341 agctagttgt aagtgctaag aaaaaaatag ataagaaaga tagtgatttg caagatatga
     2401 atggcgacaa tatgataaat gcaaataaag ataggatggt aaatgtgata aaaattggag
     2461 ttcccgataa aatgtattct aattttaaag tagatgttga aagtggttca gtagaacttt
     2521 ataatattaa aggaggagct actgttgatg tcaatgacgg gattgctaac attgttgata
     2581 acaatgtaac aaatcctttc aatataaata ctaatagtgg gatttcaggt gtaacagctg
     2641 aaactatatc atctgaaata aaatttagag caaacaatgg aattgtaaat gtaacagcta
     2701 cgaatataaa tggcaatata agtttatttg gaagcgataa taaaggtacc tttgatggaa
     2761 tatttaaatt aaatctgaaa aaagaaccat caaatttaca cttgaagtta attggaaatg
     2821 ggataaataa attgccagaa ggttggtcta aagattatat tttaggaaat ggacaaccaa
     2881 ttattgaagt taaaaataat ggcataaata atatatcaat tggagaataa aaacatatga
     2941 aaataaagtt tatatagttt taaaaattat agaattttaa aatatttata tatattctt
//
LOCUS       DAEHWM010000185         2984 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.188, whole genome shotgun sequence.
ACCESSION   DAEHWM010000185 DAEHWM010000000
VERSION     DAEHWM010000185.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2984)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.188"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            454..2265
                     /locus_tag="KNP36_003680"
     CDS             454..2265
                     /locus_tag="KNP36_003680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="HBF0875505.1"
                     /translation="MKKKYDFLIYSAIWLVIIILFIFSLYHSIEHIKIISHTGTIRSE
                     TQKVVKQELNNERNDDLIKRLDNILIKLRTGNGENGFQRCDNKEFQQKLNQMDSMWES
                     MKKEIIKVRNGASGDKLYKLSEEYSVLSNQIVFISEKHSNAKLYSFATALFIYLIFST
                     ISLLIWEYYNKKRFKRIFYTDNLTKIKNQVAFENRAIEILHNASNKEYVLLNIDIDNF
                     KYINDTHGYEYGDKVLIIVATVLSKTFNIKETCARICSDNFVILAKYRDSLLEDIREM
                     LTNAIISELDMNVTQTISYCIGAYLVEIDNLGYKSINSMMDKANIAHKVSKTRGISST
                     VWYNENLLKQLQMENSIYNYMYKAIENEEFHMYLQPKFQISSLNVVSAEALVRWFSPE
                     LGFLSPDEFIPLFEKSGFIIELDFYMLKKACSFVKKTFMKKNQYTYPIAVNFSRVTIY
                     QNSFYQRFLDTVKEYEIPFKYIEIEVTESAFNEISQPVISILEELKKLGFLISMDDFG
                     SGYSSLSLLCSLSINGLKLDKSLLKETFNREKVYSIIQCIIEMSHRIGMSVVCEGIET
                     KKDLEFLNTVKCDVGQGFYFSKPIEEKEFFNKYVTKK"
     gene            complement(2353..2934)
                     /locus_tag="KNP36_003681"
     CDS             complement(2353..2934)
                     /locus_tag="KNP36_003681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875506.1"
                     /translation="MSYLLKINQFERSYDIGIFKNEQSIYKFIEKIPFVKKDSSNFNY
                     TNYYMEFEAIPEYYEVNFNNYLYIITRFSFIPDGTEIFFTWEEIHCWDEKVATEKTFI
                     NGETLVDSYNFPNNEVKDYIQKRESLYIETKKYYEEKGLKIERHALGSEDGEYVELTN
                     DSILYLLDIEAVEIREQSKNIEEFLYKYKKRFK"
BASE COUNT         1137 a          303 c          416 g         1128 t
ORIGIN      
        1 acaaaaatag atataattta agtaatatac caaaaaaaag gaatatattt acataatatg
       61 ataaaataaa ttcaaagagt taaattgtag gtaaatagta ttttaattat ttattaaaat
      121 atagattatg tatatgccaa atttaaaaag agacataaag acattataca aatatattat
      181 tggggtgata ttttgtaaga aaagaagtga tgcagtaaat taattgagta atttaaaaat
      241 gatttaatga taatgttgat gaatgtttaa aaagaaattt tagaaaaacg tatattgctg
      301 tttgtgttgg aggtgatgaa tttgtagaat ttatagggta taaatgatta aactatttaa
      361 gataaataca tatcactgta aaatattgat aatcattttt tataagagat tgattatttg
      421 caaattatat atattacaaa tgaggtaaca ataatgaaga aaaaatatga ttttttaatt
      481 tattctgcta tttggctagt tattattatt ctttttatat tttctctata tcatagtata
      541 gagcatatta aaattataag tcacactggt actattcgca gtgaaactca aaaggttgtt
      601 aagcaagaat tgaataatga aagaaatgat gacttgataa aacgactgga taatattctg
      661 ataaagctaa gaacaggtaa tggagaaaat ggatttcaaa gatgtgataa taaagaattt
      721 caacaaaaac taaatcaaat ggattctatg tgggaatcta tgaagaaaga aattataaaa
      781 gttagaaatg gtgcttcagg tgataaatta tataaattga gtgaagagta ttctgtgttg
      841 tctaatcaaa ttgtttttat atctgaaaaa cactctaatg caaaattgta ttcttttgct
      901 actgcactat ttatttatct tatattctca acaataagtc ttttaatttg ggaatattat
      961 aataaaaaaa ggtttaaaag aatattttat actgataatt taacaaaaat aaaaaatcag
     1021 gttgcatttg aaaacagagc gattgaaatt ttgcacaatg catctaacaa agagtatgta
     1081 ctgctaaata ttgatattga caattttaaa tatattaatg atacacatgg atatgaatat
     1141 ggagataaag ttctaataat agttgcaact gttctttcta aaacttttaa tataaaagaa
     1201 acttgtgcaa gaatttgttc agataatttt gtaatacttg caaaatatag agattctctt
     1261 ttagaggata ttcgggaaat gctaactaat gctataatct ctgaattaga tatgaatgta
     1321 actcaaacta tatcttattg tataggagct tacttagttg aaattgataa tttaggttat
     1381 aaatctatca attctatgat ggataaggca aatattgcac acaaggtaag taaaacaaga
     1441 ggaatttcct ccacagtatg gtataatgaa aatctgttaa aacagttaca aatggaaaat
     1501 agtatttata attatatgta taaagcgata gaaaatgaag aatttcatat gtatttgcaa
     1561 cctaaatttc aaatatcttc tttaaatgtt gtgagcgcag aagctcttgt aagatggttt
     1621 tctccagaac ttggtttttt atcaccagat gaatttattc cattgtttga aaaaagtgga
     1681 tttattattg aattggactt ttatatgtta aaaaaagcgt gttcatttgt aaaaaaaacg
     1741 tttatgaaaa aaaatcaata tacatatccg attgcagtta atttttcaag ggttactatt
     1801 taccaaaata gtttttatca aaggttttta gatactgtta aagaatatga aattcctttt
     1861 aagtatatag agatagaggt aactgaaagt gcttttaatg aaatatctca accagttatt
     1921 tcaattttag aggaacttaa aaagttagga tttttaattt ctatggatga ttttggatca
     1981 ggatactctt cattaagtct tttatgttct ctatctatta atggattgaa gttagataaa
     2041 agcttactta aagaaacatt taaccgggag aaagtatata gtattattca gtgtattatt
     2101 gaaatgtcac atcgtatagg catgtctgtt gtatgtgaag gtattgaaac taaaaaagac
     2161 ttggaatttt taaatacagt taaatgtgat gtaggacaag ggttttattt ttctaaaccg
     2221 atagaagaaa aagaattttt taacaaatat gtaactaaaa aataatataa ttatttttat
     2281 cagtctatac attgagtcat tttatatctc gttaaatgac tcaatgcact gttatgtatt
     2341 ttaaaatata aattatttaa aacgtttttt atacttatat agaaattctt ctatattttt
     2401 tgattgttct cttatttcaa ctgcttctat atctagtaaa taaagtatag aatcatttgt
     2461 aagttcaaca tattcaccat cttctgaacc gagtgcatgt ctctcaattt ttaatccttt
     2521 ttcttcataa tatttttttg tttctatata taatgattct cgcttttgta tgtagtcttt
     2581 cacttcatta tttggaaagt tatatgaatc cactaatgtt tcgccattta taaaagtttt
     2641 ctcggtagca actttttcat cccaacaatg gatttcttcc caagtaaaaa atatctcagt
     2701 tccatctgga atgaatgaaa acctggtaat aatatataaa taattattga aatttacttc
     2761 ataatattca ggaatagctt caaattccat atagtaattt gtataattaa agttactact
     2821 atcttttttt acaaatggta ttttctcaat aaatttatat attgattgtt catttttaaa
     2881 aattcctata tcatagcttc tttcaaattg attaattttt aataaatatg acatatattc
     2941 tccttatttg ttgaaatata atttttataa ctctactaat ttta
//
LOCUS       DAEHWM010000186         2940 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.189, whole genome shotgun sequence.
ACCESSION   DAEHWM010000186 DAEHWM010000000
VERSION     DAEHWM010000186.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2940)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.189"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..676
                     /locus_tag="KNP36_003682"
     CDS             <1..676
                     /locus_tag="KNP36_003682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HBF0875507.1"
                     /translation="PLKINSSGYRIYGQNEVNKLQQILFYRELGINLENIKNIINSPN
                     FDSLSALKEHHNKLLAKRKQIDLLIENVTKTIALKEGKYTMTDIEKFEGFKEKMIDEN
                     EKNYGTEIREKYGKDIIDTSNKKLKNMSKQDYENWQNLNIEIISKLKKAFKTGDASSE
                     LAQEVAKLHHKWLCYTWNTYSKEAHSSLAQMYVYDERFTSYYDREQPGLAKFLRDAIV
                     IYTRDK"
     gene            complement(936..2864)
                     /locus_tag="KNP36_003683"
     CDS             complement(936..2864)
                     /locus_tag="KNP36_003683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HBF0875508.1"
                     /translation="MHKRLLTLFKLLNESDDKITCKTLSNHLKVSERTIRNDITSING
                     TLEKNGAIIKIKKGEGYYIDILNLALYQQYLALISDDIMDSSEIPDSPIERNQYILKY
                     ILYNNTYIKLEDLANSLYVSKFTILNDIKRIKPILSKYNLILVSKPYYGVKVEGKEID
                     IRRCISNNMINRNFENYIIGITDREIELFNNVDLIELQRVVLSEINKFNINFLDFNLK
                     NFIIHLAITVSRILDGYCLDNVLDVVLTDFQSNTTVENIFNYIESKYTIIISKADRVY
                     LYNHFITKSSLLDNVSNRVDTKIIEYVEEILEVINNQYTFDLRNDSVLFDDLVLHFKS
                     ILNSKSYNLNKVNPLINTIKSNYPLAFEITLNAIEKVFKNSIYSLTEDEIGYVSLHIG
                     AGIERFFQSNIKCKNVVLVCGSGYGSSRLLEVQLNKVFHDKINILQCLSFNQFLASEL
                     SDVDIIISTIPLNHDSIPIVLVDLKLLKKDIENISKSITNNSHIYSNLLDNFFDKNLF
                     IVNPKIKDKDELIKLMCNKLTQSEIVFPSFAESVFYRESLSSTNIDDFLAIPHPMELS
                     SIRTKICISILNEPIYWSENSTVKLIMMLAINKDDYIKINSIYDILLKIIHDNDIRDS
                     ISNCNDFDNFLSIIKSIV"
BASE COUNT         1144 a          389 c          320 g         1087 t
ORIGIN      
        1 gccacttaaa ataaattctt caggttatcg tatatatggt caaaatgaag ttaataaact
       61 tcaacaaata cttttttata gagaattagg aattaactta gaaaatataa aaaacattat
      121 aaattcacca aacttcgata gtttaagtgc gttaaaagaa caccataata aattactagc
      181 caaaagaaag caaattgatt tactaataga aaatgtaact aaaactatag ctctgaagga
      241 gggaaaatac actatgacag atatagaaaa atttgaaggt tttaaagaaa agatgattga
      301 tgaaaatgaa aaaaattatg gaactgaaat tagagagaaa tatggtaaag atattataga
      361 tacatcaaat aaaaaactta aaaatatgtc taagcaagat tatgaaaatt ggcaaaacct
      421 aaatatcgaa ataattagta aacttaaaaa agcttttaaa actggtgatg cctctagtga
      481 actggctcag gaagttgcaa aattacatca taaatggttg tgttacactt ggaacacata
      541 ctctaaagaa gctcattcct ctctagcaca gatgtatgta tatgatgaac gttttacatc
      601 atattatgat agagaacaac ctggattagc taagttttta agggatgcta tagtaatata
      661 tacaagagat aaataatata aaataataaa ggtggtgtct caaaatgaac tttttagttc
      721 atgagacact cttttttgta tgaaatcaga tatattttta tcattttatc aatgaaaaac
      781 aggtttctct ctctattttg agacagaatc tttattgtat aataattata atcaatacaa
      841 aataataaca aattatacaa aacttactta tactatttat gctaaaaaca aaaaatattt
      901 tattaaagtt tttaaaactt atgtaatata aaaatctata ctatagactt gattatggaa
      961 agaaaattat caaaatcatt acaattagat atactatctc taatatcatt gtcatgaatt
     1021 atctttaaaa ggatatcata aatggagttt atttttatat aatcatcttt atttatagcc
     1081 aacatcatga ttaatttaac agtagaattt tcactccaat atattggttc attcaatatg
     1141 gaaatacaaa tcttagttct tatagagctt aattccatag gatgaggtat agctaaaaaa
     1201 tcatctatat tggtagaaga taaactttct ctgtaaaata cagattcagc aaatgatgga
     1261 aatacaattt cactttgagt taatttgttg cacatcaact ttataagctc atctttatct
     1321 ttgattttag gattaacaat aaataaattt ttatcaaaga aattgtccaa aagattacta
     1381 taaatatggg aattattagt gattgactta gatatattct ctatatcttt ttttaatagt
     1441 tttaaatcca ctaatacaat aggaatacta tcatgattta aaggaattgt cgatattatt
     1501 atatctacat ctgacaattc actagctaaa aattgattaa atgatagaca ttgaagtata
     1561 tttattttat catgaaaaac tttgtttaat tgaacctcta ataacctact tgaaccatac
     1621 cctgaaccac atactaatac tacgttttta cacttaatat tactttgaaa aaatctctct
     1681 attccagcac ctatatgcag ggatacatat ccaatttcat cttctgttaa agagtaaata
     1741 ctatttttaa aaactttttc tatagcattt aaagttattt caaatgctaa aggataatta
     1801 ctctttattg tatttataag gggattcacc ttatttaaat tataagattt agaattgaga
     1861 attgatttaa agtgcagtac taaatcatca aataatacac tatcatttct aaggtcaaaa
     1921 gtatattgat tgttgattac ttctaaaatt tcttcaacat actctataat tttagtatct
     1981 accctattgg aaacgttatc caaaagagaa cttttagtta taaaatgatt atatagataa
     2041 actctgtctg cctttgaaat aattatagta tatttactct caatataatt aaatatattt
     2101 tcaacagttg tattcgattg aaaatctgtt aaaacaacat ctaaaacatt atctaagcag
     2161 taaccatcaa gtattctact tacagtaata gctaaatgga taataaagtt ttttagatta
     2221 aaatctagga aattgatatt aaatttatta atttcactta acactaccct ttgaagctct
     2281 attaaatcta cattattaaa taattctatt tctctatctg taattccaat tatatagttt
     2341 tcaaaattcc tatttatcat attattagaa atacatcttc gaatatctat ttccttacct
     2401 tcaactttaa ctccataata tggcttagaa actaatatta aattatactt tgacaaaata
     2461 ggctttattc tttttatgtc atttagtatt gtaaatttac tcacatacaa gctattagct
     2521 aaatcttcta gttttatata tgtattgtta tagagaatat attttaaaat atattgattt
     2581 ctttctatag gagaatctgg tatttcactt gaatccataa tatcatcaga tattaatgct
     2641 agatactgtt ggtataatgc taaattaaga atatctatat aatatccttc tccttttttt
     2701 attttaataa tagcaccatt tttctctaaa gttccattta tagaagtaat atcatttctt
     2761 atagttctct cactcacttt taaatgatta cttaaagttt tacaagtaat tttatcatca
     2821 ctttcattta ataatttaaa caacgtgagc aatctcttgt gcataaatat ccccccttat
     2881 agaatttctt ctaaattata ctatttacac tcatataata caattactct aataaaattg
//
LOCUS       DAEHWM010000187         2810 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.190, whole genome shotgun sequence.
ACCESSION   DAEHWM010000187 DAEHWM010000000
VERSION     DAEHWM010000187.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2810)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.190"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            1535..2806
                     /locus_tag="KNP36_003684"
     CDS             1535..2806
                     /locus_tag="KNP36_003684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /protein_id="HBF0875509.1"
                     /translation="MLKVLKGNIIFTKTSETFTVFENSYIMLEKGKVKGIFKEIPKEY
                     KNLKVVDYTDKLIIPGMNDLHAHASQFKNLGMAMDKELLPWLETYTFPEESNYKDIEY
                     ATKMYKKFVKELWKSGTTRIAVFATVHKEASMKLMDIFKEVGLGAYVGKVNMNMNCPD
                     TLLENTQDSITDTEEIINKYSDTDSIVKPIITPRFIPSCTSELLKGLGDLCLKYNIPI
                     QSHLSENYDEIEWVRSLEPESKFYGDAYNRYNLFGQTPTLMAHCVHCSQDEIDLMREN
                     NVMAVHCPASNFNVGSGAMPIRKLIDNNIRLALGSDISGGHTLSIFKAMVSAIQLSKL
                     YWVNSGKKYNFLSLSEAFYIATKSGGSFFGKVGSFEEGYDFDALIIDDSNLNHDNYSI
                     LERLERFIYVGDDRNIIHRYVCGKLIEEPNI"
BASE COUNT         1099 a          339 c          351 g         1021 t
ORIGIN      
        1 tgaattaaca gcaatataaa aaagattgct aataaaataa agttataatt tttttctttt
       61 aatctaaaat tagctataat aacaatgaaa ctatataaag catataaaaa ttttttcata
      121 aaaaacacct aaattctata tttgtatttt atattgagcc aaatctaatt tctgtatatt
      181 tattaagtgt agttctagtt cctattgtag tagcattaaa tattttttaa tttttatttt
      241 caaagggcat ctccttatat ttaaattata gtatgaatat tcataaattt caatctattt
      301 ataaggtaat tattttttat atctaatatc ttgtcattaa gttttattat atatatttat
      361 aaatttttca atacttttta taattattct acttttatat tttaatcatt aaaactaaag
      421 tcaatgttat ctggtaatta tttactacaa atgataaaaa ataattatat tttaaaggat
      481 aaaatgctgt ataaattatt ggggtatttt acctatactt gttacaaatt tacataccac
      541 ttagttaata taaaacaaat ttcaaagaga ttggacaacg aataaaaatt gcaatttata
      601 taccatatag ttaatataaa gcatatttgt gtcgatatat agttctaact aagtataaga
      661 tttacatacc tcatagttaa tataaaacac atattttaca tgtttgaaga ttttatcaga
      721 aaccctattt acataccgca tagttaatat aaaactatta atagtgctat gttgtttatt
      781 tgcattaaca agatttacat accacatagt taatataaaa catgtttagc aggagttatg
      841 atgataaaac acattattta tttacatacc acttagttaa tataaaaccc caaaataaac
      901 taagtatttt cagtacttac acacatacaa ctctctcaaa tttgcagtga accatgagta
      961 gtgcaattga taacatttat catacaccct caatccctta cattgcaact gttaaaccct
     1021 actttatcaa aaatatcgct cactgcaaaa tttatatatt tttattatat cataaaattc
     1081 aaactataaa attaaaatgg aataatttat caatttaaga acacctacat atttgtaaat
     1141 acttactata ttatctattc taatagttct tcttctagct agaactaata taaaaatcat
     1201 ctctgaaaga ttaggacata ctaatataaa aataactatg aatagatatt ttcttgtttt
     1261 aaacgatatg gataaaaaaa cttctgaaaa tataatcaaa gttctcttta aataacattc
     1321 cattttatgt aagtaggcat tatatttttc ttaaatgtca cttaaatgtc agttatatat
     1381 aataatagta aacaactgta tttcactaat atttgctatt atctaatagt atttatagtt
     1441 tagatttgat ataatacatg tggtaaaatt ttgatttgta aaacaaaatt ttacctacat
     1501 atattaaaac aaatttaaaa ctaaggagac ctatatgtta aaagtactaa aaggaaatat
     1561 aatttttaca aaaacttcag aaactttcac agtatttgaa aatagttata ttatgctgga
     1621 aaaaggtaaa gtaaagggaa tatttaaaga gatacctaag gaatacaaaa acctaaaagt
     1681 agtagattac actgataagc ttataatacc tggtatgaat gacctccatg cccatgcctc
     1741 tcaatttaaa aatcttggaa tggctatgga taaagagctt ttgccatggc ttgaaactta
     1801 tacatttcca gaagaatcaa attataaaga tatagaatat gcaacaaaaa tgtataaaaa
     1861 atttgtaaaa gaactttgga aatctggaac tacaagaata gcagtgtttg caacagtaca
     1921 taaagaagcc tctatgaaac ttatggatat attcaaagaa gttggtcttg gagcatacgt
     1981 tggtaaagta aatatgaata tgaattgccc tgatacttta ttagaaaaca ctcaggattc
     2041 tattactgat acagaagaaa ttataaataa gtatagtgat acagattcta ttgtaaaacc
     2101 aataataaca cctagattta taccaagctg tacaagtgaa cttttaaaag gtttaggaga
     2161 tttatgttta aaatataata ttcctattca atcacactta tctgaaaatt atgatgagat
     2221 tgaatgggtt agaagtctag aacctgaatc taaattctat ggagatgcat ataatagata
     2281 taatttattt ggtcaaactc ctactttaat ggctcattgt gttcattgtt ctcaggatga
     2341 aatagattta atgagagaaa ataatgttat ggcagttcac tgtccagctt ctaactttaa
     2401 tgttggtagt ggtgctatgc ctatcagaaa attaatcgat aataatatta gattagcact
     2461 tggatcagat ataagtggtg gacatacatt gtcaatattt aaagcaatgg tatctgcaat
     2521 acaattatct aaattatatt gggttaactc tggtaagaag tataatttct tatctttatc
     2581 tgaggctttt tatattgcaa ccaaaagtgg tggaagtttc tttggaaaag ttggtagctt
     2641 tgaagaaggt tatgattttg atgcattgat tattgatgat tcaaatttaa atcatgacaa
     2701 ttattctata cttgaaagac ttgaaagatt tatatatgtt ggtgatgata gaaatatcat
     2761 tcatagatat gtatgtggaa aactaattga agaacctaat atataattat
//
LOCUS       DAEHWM010000188         2795 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.191, whole genome shotgun sequence.
ACCESSION   DAEHWM010000188 DAEHWM010000000
VERSION     DAEHWM010000188.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2795)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.191"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(363..1259)
                     /locus_tag="KNP36_003685"
     CDS             complement(363..1259)
                     /locus_tag="KNP36_003685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HBF0875510.1"
                     /translation="MKDKNTYFNRKGQENFIDIFLKDDIKKGANFKRHWHEHLQIYYF
                     IDGIAYLECGLDNFKVVPGNIVIANSNELHYLESLSDNLKFYSIRIEPTFLFSNQVDL
                     LQTKYLAPLALNHIVFNNLIQNDSLILKCITTILDEYHNKEVGYELSIKANIYQLIVL
                     LLRSHIDKIYSEDEFIKRKYSLEKFECIFDLIEEKYMDKITLKELASHVNLSAHHFCR
                     TFKQITGKTTIDFINGIRLDKAIYYLKETDLNMTEIAMRCGFDSINYFSRLFKRNYNI
                     SPTKYRNEHKEVSNVILKEDMK"
     gene            1400..>2795
                     /locus_tag="KNP36_003686"
     CDS             1400..>2795
                     /locus_tag="KNP36_003686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HBF0875511.1"
                     /translation="MTNSFKKDDNRKKITVLFVVIAMTFMATLDSSIINVALPVLASK
                     LNVSLASIEWVIASYSIIICSTLLFFGRLGDIIGKSRVFQVGTILFTSASLLCGLSNS
                     LTLLIVCRFIQGIGASAYMANNHGIITELFPKESRGKALGILVTAVAIGNMVGPSVGG
                     FILSIFDWNVIFFINIPIGLIVIFLNTKFLPNSKKSSENMDKTGAILQFLGTTLFFSA
                     LISAQQTGLLNPYILIALLLSIIFIILFLILEKKHPQPLLDLEIFRNFKFSLNLICAL
                     TSFICIASSSILIPFYLQSTMKLPPIQAGLFMILSPLILAIFSPIFGNISDKIKSEKI
                     ILIGLLVMSFGFFLMSRLKESSALILFVIYISIISIGQAIFQPANNALIMSSCSRSKL
                     GVVGSINSLVRNLGQVIGITISTTLLYNFMSIKAGYRVNDYVINNDKIFVFGMRNVYI
                     IVTLVCLIGAILIGF"
BASE COUNT          950 a          385 c          327 g         1133 t
ORIGIN      
        1 tatttgactt tcttttaatt ctttaggatg gatttaaatt ttctataaaa atcatactat
       61 tttagctgtt tacttgctta tttaatagtt ttatttcttt gattaaatat ctttcagaat
      121 ctaagccaga tgtctcaaaa aaactgattt ataatataat cattttttct gctattctta
      181 tttttccaat tttagtttca tattaaaata tacttttcat agacactaca ttctttcata
      241 ctcattttca catttaacta tacaagtagt cttactcatt tatgtactat actttattaa
      301 tatttattaa gaaaaactca aagatttaaa aatatatatt ttctataaag tatatttatg
      361 aattatttca tatcttcttt taaaataaca ttactaactt ctttatgttc atttctatac
      421 ttagttggag atatattata attcctttta aataagcgac taaaataatt tatgctatca
      481 aagccacatc tcatagcaat ttctgtcata tttaaatctg tttcctttaa ataatatata
      541 gctttatcaa gcctgattcc atttataaaa tcgattgtag tcttacctgt tatttgctta
      601 aatgttctac aaaagtgatg tgcactcaag ttcacatgac tagcaagttc ttttaatgta
      661 attttatcca tatatttttc ttctatcaaa tcaaagatac attcaaattt ttctaaagaa
      721 tactttcttt ttataaattc atcttcagaa tatattttat caatatgact tcttaataag
      781 agtactatta attgatagat attagctttt atagataact catatccaac ttctttattg
      841 tgatattcat caagtatagt tgtaatacat tttaaaatca gagaatcatt ttgaattaaa
      901 ttattaaata caatatgatt taaagccaat ggtgctaagt acttggtttg taacaaatca
      961 acttgattac taaaaaggaa tgtgggttca atacgaatac tatagaattt taaattatct
     1021 gataagcttt ctaaataatg taattcatta ctgtttgcta ttacaatatt tccaggcact
     1081 accttaaaat tatccaatcc acattcaaga tatgctatac catcaataaa ataatatatt
     1141 tgtagatgct catgccaatg tcttttaaag tttgctcctt ttttaatgtc atcctttaaa
     1201 aaaatatcta taaagttttc ttgacctttc ctgttaaaat atgtattttt atccttcatt
     1261 attcccccct catcaaaata gtgctaatta taagcaatat agttattgta ttcattattt
     1321 catatcgcta ttatataaaa tgtaactatc attgtaaaca ttaacataat gcagtcatta
     1381 taataaggag gtaataaaaa tgacaaactc ttttaaaaaa gatgataata gaaaaaaaat
     1441 cacagtttta tttgtagtca ttgccatgac ttttatggca acattagatt ctagtattat
     1501 aaatgttgct ctcccagttc ttgcaagcaa actaaatgta tctctagcat ctattgaatg
     1561 ggtaatagca agttactcaa ttattatttg ttcaacacta ttattttttg gaagacttgg
     1621 agatattatt ggtaaatcaa gagtatttca agtaggtact attctcttta catcagcttc
     1681 attactatgt ggattaagta attctttaac tttacttata gtttgccgct ttattcaagg
     1741 aataggcgct tctgcctaca tggcaaacaa tcatggaatt atcacagaac tatttccaaa
     1801 agaaagcaga ggaaaagccc tagggatttt agttactgca gttgctattg gaaatatggt
     1861 tggaccatct gtgggaggat ttattttgtc aatatttgat tggaatgtta tattttttat
     1921 aaatattcca atcggtctta ttgtaatctt tttaaataca aaatttcttc ctaatagtaa
     1981 aaaatcttca gaaaatatgg ataaaactgg tgctatactt caatttttag gaacaacatt
     2041 attttttagt gctctaatta gtgctcaaca aacaggatta ctaaatccat atatattaat
     2101 tgcactatta ttatcaatta tttttattat attatttttg atattagaaa aaaaacatcc
     2161 tcaaccgctt cttgaccttg aaatttttag aaattttaaa ttttcattga atttaatttg
     2221 tgctcttaca tcattcattt gtattgcatc atcaagtatt ttaattccat tttatttaca
     2281 aagtactatg aaacttcccc ctattcaagc aggtttattt atgatactat cacctttgat
     2341 tttagccatt ttttcaccta tatttgggaa tatatcagat aaaattaagt cagaaaaaat
     2401 tattttaatt ggtcttctcg ttatgagttt tggattcttt ctaatgtcaa gattgaaaga
     2461 aagttctgcc cttattttat ttgtaattta tatatcgata atatcaatag gacaagctat
     2521 atttcaacct gctaacaatg ctttgataat gtcaagctgt tctagaagta agctaggagt
     2581 tgtaggaagc ataaattccc ttgtaagaaa tttaggacaa gttataggta ttactatttc
     2641 tacaacactt ttatataatt ttatgagtat taaagctgga tatagggtca atgattatgt
     2701 gattaataat gataaaatat ttgtatttgg aatgagaaat gtttatatta ttgttacact
     2761 tgtttgctta ataggtgcaa tattaattgg ctttt
//
LOCUS       DAEHWM010000189         2604 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.192, whole genome shotgun sequence.
ACCESSION   DAEHWM010000189 DAEHWM010000000
VERSION     DAEHWM010000189.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2604)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.192"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(215..1465)
                     /locus_tag="KNP36_003687"
     CDS             complement(215..1465)
                     /locus_tag="KNP36_003687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003418703.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1015 domain-containing protein"
                     /protein_id="HBF0875512.1"
                     /translation="MATIKPFKAIRPNKYIVDKVAALPYDVMNSKEARRIAEGNPYSF
                     LHIDKSEIDLDENIDLYDEKVYLKARENLDEFRKQEILVKDDKECIYIYKQIMDGRAQ
                     VGIVACISVDESLNGTIKKHEYTRPEKEIDRTKHIKYCDANTGTILVTYKHQRVIDDI
                     INDFMDNNEPLYDFITDDKIEHTVWKIDNDDIIDNLVDKFEKLDYLYIADGHHRTASA
                     ENVAKEMRAKNPNYTGKEEFNYFIAMIAPDENLMVLDYNRVIKDLNGLSEEEFINKIK
                     ENFELEEIEGKEKYKPDKKGTFGMYLGDKWYKMKANKNLLEIEDPVDSLDISILQDYV
                     IDAILGIDNPRVDKRIDFIGGIRGLEELEKRVNEDMKVAFAMYPTSIEDLIRVADANK
                     IMPAKSTWFEPKVRCGLFLHEINE"
     gene            complement(1497..2438)
                     /locus_tag="KNP36_003688"
     CDS             complement(1497..2438)
                     /locus_tag="KNP36_003688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-3-phosphoglycerate dehydrogenase"
                     /protein_id="HBF0875513.1"
                     /translation="MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDV
                     LVVRSATKVTKDVIDKALEGKKLKLIVRGGVGLDNIDVKYAQANGIKVMNTPNASSIS
                     VAELTIGQLFVLARFINTANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKR
                     AELLGMNVIYTDIMGEAQGFNNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEIN
                     KMKKGAYLINCARGGLVDEKDLLKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPT
                     PHIGASTVEAQERIGDEIVNVIQDFFLDFNNLIGVAL"
BASE COUNT          784 a          495 c          243 g         1082 t
ORIGIN      
        1 aaaaccttat aaatatacaa atacaattat atgaattttc atcctcaatt atagcataga
       61 atatgactat ctatatccta aaattatcca tttctaaaaa aaaggtaact attattaaga
      121 atatcaactt atagaattta tattccacat acgattttca atcaaaaaaa caagggctaa
      181 aaagtgaatt gtgcactttt tagcccttta ttaattattc atttatttca tgtaagaata
      241 gaccacatct tactttaggt tcaaaccatg ttgacttagc tggcattatc ttatttgcat
      301 ctgctactct tattaaatct tcaatactag taggatacat tgcaaatgct actttcatat
      361 cttcattaac tcttttttct aattcttcaa gacctctaat tccaccgata aaatcaattc
      421 ttttatctac tctaggatta tcaattccta aaatagcatc aataacatag tcttgtaata
      481 tagaaatgtc taatgagtca acagggtctt ctatttctaa taaattttta tttgctttca
      541 ttttatacca cttatcacct aggtacattc cgaaagttcc ttttttgtca ggtttatatt
      601 tttcttttcc ttctatttct tctagttcaa aattttcttt tattttattt ataaattctt
      661 cctcgcttaa accatttaag tctttgataa ccctattata atccaaaacc attaaattct
      721 catctggtgc aatcattgct atgaagtaat taaattcttc ttttccagta taatttggat
      781 ttttagctct catttctttg gctacatttt ctgctgaagc tgtcctatga tgaccatctg
      841 caatgtatag ataatctaat ttttcaaatt tatctactag gttatctatt atatcatcat
      901 tatcaatctt ccatactgta tgctctatct tgtcatctgt tatgaaatca tataaaggtt
      961 cattattatc cataaaatca ttgattatat catctatcac cctttgatgt ttgtaagtta
     1021 caagtatagt tcccgtatta gcatcacagt attttatgtg tttagttcta tcaatttcct
     1081 tttctggtcg agtgtactca tgttttttta ttgttccatt caagctttca tcaactgata
     1141 tacatgctac tataccaact tgagctctac catccatgat ttgtttatat atatatatac
     1201 actctttgtc atcttttact agaatttctt gttttcgaaa ctcatctaaa ttttctcgcg
     1261 cttttaaata aactttttca tcatataaat ctatattttc atctaaatca atttctgatt
     1321 tatctatatg caaaaatgaa tatggattcc cttctgcaat tcttctagct tctttactat
     1381 tcataacatc gtaaggaagt gctgctactt tatctactat atatttattt ggtctaatcg
     1441 ccttaaatgg tttaatcgtt gccattacta atttcctcct aattatacaa aatattttat
     1501 aatgctaccc ctattagatt gttgaagtca agaaagaaat cttgaatcac atttactatt
     1561 tcgtctccta ttctttcttg agcttctact gtagatgccc caatatgagg tgtaggagaa
     1621 actcttggat gatttactaa gtctaaattt aatgtaggtt cttgttcata aacatctata
     1681 gcagctgctg ataatttacc ttcatctaat gcttttagta aatctttttc atcaactaaa
     1741 ccgcctcttg cacagtttat taaataagcc cctttcttca tcttatttat ttctttttca
     1801 gttattactg cccccttatt cttatcaaat ggtatgtgta aagataagaa atctgcattt
     1861 tctaaaactt cttccatatc acagaattta taattgttaa agccttgcgc ctcacccatt
     1921 atgtcagtat atataacatt catacctaat aattctgctc tctttgcaac ttcttttgca
     1981 attcttccaa aacctataag tccaagtgtc tttccattaa tttctgtacc tttatacttt
     2041 ttcttctccc attttccatc tctcatagtt acatttgcag tatttatgaa tcttgcaaga
     2101 acaaataatt gacctattgt aagctctgca acagatatac tgcttgcatt tggagtattc
     2161 ataactttta tgccattagc ttgagcatat ttaacatcta tattatccag acctactcca
     2221 cctcttacta tcaacttcaa ctttttaccc tctaatgctt tatctattac atctttagta
     2281 actttagtag ctgaacgtac tacaagtaca tcaacatctt taagtttatc tcctaaaaca
     2341 tctttttcat aaaactgctc tatcacatta aaatctaact ctctcaattt tctcgctgct
     2401 tctttctcta ttccatcagt aactaatata ttatacataa caaactcctc caatttttat
     2461 tcacttaatt tttccaattt ttatttttta aagtattttc atcaataaaa aactttactt
     2521 aatttaactt tctgtttata taattttcaa aatatttttt tattaaagtc atatcaaatt
     2581 tttctattgt ttgttaaaaa ttta
//
LOCUS       DAEHWM010000190         2594 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.193, whole genome shotgun sequence.
ACCESSION   DAEHWM010000190 DAEHWM010000000
VERSION     DAEHWM010000190.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2594)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.193"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            262..2280
                     /locus_tag="KNP36_003689"
     CDS             262..2280
                     /locus_tag="KNP36_003689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009892871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HBF0875514.1"
                     /translation="MRRNTKLLTTGILSMAIVAPTMAFATESNAMENNADLNINLEKK
                     SIVLGSTSKVSVKFKEKPDADSITLKYKCYDMPLDTTLNYNQSTESYEGTINYNKDPE
                     YLNVWELQGITINSKNNPKTLNKQELEKMGLNLKDYNVTQECIIEDITSRKDVNKYLR
                     KTSAPITELTGSDRYETAVKISKEGWKNGSDKVVIINGDVSIDGIISTPLATTYNAPI
                     LLVEKNNVPNSVKSELKRLNPRDVIIIGDENAISKTTANQIKSTVNASQTRLKGSNRY
                     ETSLLIAKEIDKNHDVEKVYITNANGGEVDALTIAAKAGQDKQPIILTDKNSITDNTY
                     KWLKSEDLQNAYFIGGPQMISTNVINKVNDITKDNVTNNRVYGADRHETNANVIKKFY
                     TDDELEAVLVAKSDVLVDALAAGPLAANLKSPILITPKTYVSAYHKENLEAKSANKVY
                     KIGGGLTSKVMSSIASSLSKHNTTPTEPGNSGGKTVMIDPGHGGSDTGTTGKPLGGIR
                     EKDYTLNTSLATTEYLRSKGFNVIMTRDTDKTLSLGNRTALSNSLRPDLFTSIHYNAS
                     DTTGNGVEVFYKLKDKDGGTTKTVATNILNRILEKFNLKNRGAKTRTLSTDPTKDYLY
                     VLRNNDMPAVLVECAFLDNEKDMSLLNTSNKVKEMGTQIGKGIEDSLK"
BASE COUNT         1070 a          306 c          431 g          787 t
ORIGIN      
        1 ttgtattaaa tttaataaac ctacaattgt tatatgtttt tatttgtctt ttatagattt
       61 ttttggcaat aaatgatata gtgaagataa ttaaatatat tcaatatatt taattttttt
      121 attttttgtt tttataattt ttttagaagt ttatttttta tgtacttatt tataattttg
      181 ggtaaaaaca ctttgatata atttcaaaaa ttaaaaggtt aaaaaacaaa gtagaaattt
      241 atgttaaata aggagattaa tatgagaaga aatacaaaat tattaacaac agggattctt
      301 tcaatggcaa tcgtcgcacc tacaatggca tttgctactg aatctaatgc tatggaaaat
      361 aacgctgatt taaatataaa cttagagaaa aaaagtatcg ttttaggtag tacctcaaaa
      421 gtcagtgtta agtttaaaga aaaaccagat gcagatagca ttacattaaa gtataaatgc
      481 tatgatatgc cattggatac aactttaaac tataatcaat caactgagtc atatgaagga
      541 actatcaatt ataataaaga cccagaatat ctaaatgttt gggaactaca agggataaca
      601 ataaacagca aaaataatcc taaaacttta aacaaacaag aactagaaaa gatgggatta
      661 aatttaaaag actataatgt aacgcaggaa tgtataattg aagatataac ttctagaaaa
      721 gatgtaaata aatatttaag aaaaacttct gcacctatta cagaacttac aggaagtgat
      781 agatacgaaa cagcagttaa aataagtaaa gaaggctgga aaaatggttc agataaggta
      841 gttataataa atggggatgt aagtatagat ggcattatat caactccact agcaactaca
      901 tataatgcgc caatactttt ggttgaaaaa aacaatgtac ctaatagtgt aaaatcagaa
      961 ttaaagcgtt taaatcctag agatgtaatt ataattggag atgagaatgc tatttctaaa
     1021 actactgcta atcaaattaa atcgactgta aatgctagtc aaacacgtct aaagggctct
     1081 aatagatatg agacatcttt attgatagca aaggaaatag ataaaaatca tgatgtggaa
     1141 aaagtataca taacaaatgc taatggcgga gaagtggatg cacttactat agcagcaaaa
     1201 gcaggtcaag acaagcaacc aattatatta actgataaaa atagtattac agacaacaca
     1261 tataaatggt taaagagtga ggatttacaa aatgcttatt ttataggtgg ccctcaaatg
     1321 atatcaacaa atgttataaa taaggtaaat gatataacta aagataatgt tactaataat
     1381 agagtatatg gagcagatag acacgaaaca aatgcaaacg taataaaaaa attctataca
     1441 gatgatgagt tagaggctgt tttagtagct aaatcagatg tacttgttga tgctttagca
     1501 gcaggtccat tggctgcgaa cttaaaatct ccaatactta taacaccaaa gacatatgta
     1561 tctgcatacc ataaagaaaa cttagaagct aaatcggcaa ataaggtata taaaataggt
     1621 ggaggattga cttctaaggt aatgagctct atagcatcat cattatctaa acacaataca
     1681 actccaacag aaccaggaaa tagtgggggc aagacagtta tgattgaccc aggacatggt
     1741 ggttcggaca ctggaacaac aggtaaacca ttagggggta ttagagaaaa agactataca
     1801 ttaaatactt cacttgcgac aactgaatat ttacgttcaa agggattcaa tgtaataatg
     1861 acaagagaca cagataagac tttatctctt ggaaatagaa ctgctttatc taactctttg
     1921 agaccagatt tatttacgag tatacactat aatgcatctg atacaactgg gaatggtgta
     1981 gaagtatttt ataagcttaa agataaagat ggagggacta ctaaaactgt agctacaaat
     2041 atattaaata gaatcttaga gaaatttaat ctaaaaaata gaggtgcaaa aacaagaaca
     2101 ctatcaactg accctacaaa agattattta tatgttttaa gaaataatga tatgccagct
     2161 gtacttgtag aatgtgcatt tttggataat gagaaagata tgagtttact taatacatca
     2221 aataaagtaa aagaaatggg tacacaaata ggtaaaggca tagaagattc attaaaatag
     2281 tctacaatga gagcatagaa aaatttaaaa taaattaatc tgcaatttta aatttaaact
     2341 aaagctataa gataagaatg taattataat agtaataaag actgtatata cattgtgcat
     2401 ataagtgcga aatgaggtat atacagtctt tttatgatta attgtaaaag gatttatatt
     2461 atatgaagaa tttacatatc ttaaggctac agttaattgt caagagttgg agtattcatt
     2521 tgtaatacac aataaaagct taattactat attttattgt gtgtttgtgt gttttttgtg
     2581 gatttttatg tcaa
//
LOCUS       DAEHWM010000191         2587 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.194, whole genome shotgun sequence.
ACCESSION   DAEHWM010000191 DAEHWM010000000
VERSION     DAEHWM010000191.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2587)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.194"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            264..2399
                     /gene="rnr"
                     /locus_tag="KNP36_003690"
     CDS             264..2399
                     /gene="rnr"
                     /locus_tag="KNP36_003690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HBF0875515.1"
                     /translation="MIPGLKESLLGLINESAYNPLKKEELAEIFDIHSSEMPMFYNFL
                     NELEEDGYICFTKKGKIVSPNQMGYFVGKFVSHKKGFGFVESDVEYTQDLFISSDNIN
                     GAMHNDRVMAEIVVPATEEKRAEGRIVKVIKREITRIVGTFQSSKTFGFVTPDNKKFT
                     KDIYIPKKHFSGAVDNDKVVCEITVWPQEDRKPEGKIIEILGQKGERGVEIDSIIREH
                     GLPEEFPKKVLQEAEAVAVEIPQEEIKRRRDLRDLNIFTIDGDDAKDLDDAISIEVLP
                     NGNFKLGVHIADVTHYVREKNKLDKEALKRATSVYLVDKVIPMLPKTLSNGVCSLNPF
                     EDKLTLSIFMEIDHKGNVVKHEICESVINSKARMTYTEVSDILEKDDEKLKKTFEHVV
                     EDFKNAEILARILMSRREKRGAIDFNFPEAKIILNGKGEVVDIKPYERRISNKIIEEF
                     MLISNETIAEHFYWMGIPFVYRIHETPSLEKMEELSKFISTFGYIIKGDKEEVHPKAL
                     QGIIEKIKGKKEEGAISTIMLRSLKQAKYSPECSGHFGLAAKFYCHFTSPIRRYPDLQ
                     IHRIIKESLNNKISGKRQEQLTTIVDYASVQSSEKERKAELAERDVHDFYKALYMKDK
                     VGQEFEGVVSSVTSFGIFVELDNTIEGLIRLANMNDDYYIYDESSYSVLGERTKKSYK
                     IGDLVKIKVESVNVDFKEIDFEIVEKIEE"
BASE COUNT         1121 a          253 c          474 g          739 t
ORIGIN      
        1 gataaagagt aatttaagca attatgataa agaataactt aagtaattat aatgatattt
       61 acaaataatt tataaaacat cataatttgt ttgaagttag tatgacaaag cttacattaa
      121 atcaaaaata taaataagta attttaactt ataataataa gaaaatatag aaaattatgt
      181 gataattaaa aaatgttttg tctgaagaaa tataaaagac aatataaata ataatataat
      241 gaaaagtaaa acaggaggga aaaatgatac caggacttaa agaaagtttg ctaggattaa
      301 taaatgaaag tgcatataat cctctaaaaa aagaagaatt agcagaaata tttgatatac
      361 attcatcaga aatgccaatg ttttataatt ttttaaatga attagaagaa gatggttata
      421 tctgctttac taaaaaagga aaaatagtat ctcccaatca aatgggatac tttgttggaa
      481 aatttgtatc acacaaaaag ggttttggat ttgtagaatc tgatgttgaa tatacacagg
      541 atttatttat ctcaagtgac aatataaatg gtgctatgca taatgataga gttatggcag
      601 aaatagtagt acctgcaact gaagaaaaga gagcagaagg aagaatagta aaagtaataa
      661 agagagaaat aactagaata gtaggtactt tccaatcaag taaaactttt ggatttgtaa
      721 caccagacaa caagaaattt actaaagata tatatatacc taaaaaacat tttagtggag
      781 cagtagataa tgataaggta gtatgtgaaa ttacagtatg gccacaagag gatagaaaac
      841 cagaaggcaa aattatagag atactaggtc aaaaaggtga aagaggcgta gaaatagatt
      901 ctataataag agaacatggt cttccagaag aatttccaaa gaaagtattg caagaagcag
      961 aagctgtagc tgttgagatt cctcaagaag agataaaaag aagaagagat ttaagagatt
     1021 taaacatatt tactatagat ggagatgacg caaaagactt agatgatgcc atatcaatag
     1081 aagtattacc taatggaaac ttcaaactag gagttcacat agctgatgtt acacattatg
     1141 taagagagaa aaataaactt gacaaggaag ccttaaaaag agctacatca gtttatttag
     1201 tagataaagt aattccaatg ttgccaaaaa ctctttcaaa tggagtatgt agcttaaatc
     1261 catttgaaga taaattaact ctttctatat ttatggaaat agaccataaa ggaaatgtgg
     1321 ttaaacatga aatatgtgaa tctgtaataa attcaaaagc tagaatgact tatacagaag
     1381 tatctgatat attagaaaag gatgatgaaa aacttaaaaa gacttttgaa catgttgttg
     1441 aagattttaa aaatgctgaa attttagcta ggattcttat gtcaagaagg gaaaaaagag
     1501 gagctataga cttcaatttc ccagaggcaa agataattct aaatggaaaa ggcgaagttg
     1561 tagatataaa gccatatgaa agaagaatat ctaataagat aatagaagaa tttatgctta
     1621 taagtaatga gacaattgcc gaacattttt actggatggg aataccgttt gtgtatagaa
     1681 tacatgagac accatctttg gaaaaaatgg aagaattgag taagtttata tctacatttg
     1741 gatatataat aaaaggtgat aaagaggaag tacatccaaa agcattacaa ggtataatag
     1801 agaaaataaa gggcaaaaaa gaagaaggag ctatcagtac tataatgctt cgttctttaa
     1861 aacaagctaa gtactcacca gaatgtagtg gacattttgg attagcagct aaattctact
     1921 gtcactttac ttcaccaata agaagatatc ctgaccttca aattcataga ataataaaag
     1981 aatctttaaa taataaaata agtggaaaaa gacaagaaca gcttactact atagtggatt
     2041 atgcatctgt tcaatcatcc gagaaagaaa gaaaggcaga gttagctgaa agagatgtac
     2101 atgatttcta taaggctctt tatatgaagg ataaagttgg tcaagaattt gagggtgttg
     2161 tatctagcgt aacttcattt ggaatatttg ttgagttgga taataccata gaaggattga
     2221 taagacttgc aaatatgaat gatgattact atatttatga tgagagttct tatagtgttt
     2281 taggagaaag aactaagaag tcatataaga taggagacct tgttaagata aaggttgaaa
     2341 gtgttaatgt agattttaaa gaaattgact ttgagatagt tgaaaaaata gaggagtaga
     2401 taaaacagct aaaataagag ataacaagtt gtagtattta tgatatgtat aaatatatag
     2461 tgcacaatac tctataaaat aaatgataaa aataggtaat tgagaaatat ctaatggaaa
     2521 tagttaactg aaagataaat aattaagaaa tatttaatga aagtagctaa ttgaaaaata
     2581 agtaatt
//
LOCUS       DAEHWM010000192         2556 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.195, whole genome shotgun sequence.
ACCESSION   DAEHWM010000192 DAEHWM010000000
VERSION     DAEHWM010000192.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2556)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.195"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            34..507
                     /locus_tag="KNP36_003691"
     CDS             34..507
                     /locus_tag="KNP36_003691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HBF0875516.1"
                     /translation="MFKEYLIRELKEDDIKNALDLIWNVFEEFESPDYCDEGITTFHQ
                     FIEYNSIIEKIKEKTLFFWGCFDSKKLIGVLAIRNLNHICMLFVDKNYHKHGVAKKLM
                     TTGIQYCICNKFNLTEITVNSSPYAVEVYHKLGFKDTAVEQIVDGIRFTPMKLLI"
     gene            complement(876..1433)
                     /locus_tag="KNP36_003692"
     CDS             complement(876..1433)
                     /locus_tag="KNP36_003692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0875517.1"
                     /translation="MRVSREIVIQATSDIVNKDGLNKVSLKVIAEKLGIRTPSLYNHI
                     ESLDDLLLEVAHKGMREMNSQMIKATIGNFGDTAIKCISIAYFNFIISNPGVYETIQW
                     ATWHGNNETLEIFDEYKSLLEKLILSCNLNTKNTGEVLNLIMSVLHGYSTLQLGKSLL
                     SKEEAIKGLADSIDTVLLGIHKKYD"
     gene            1691..2389
                     /locus_tag="KNP36_003693"
     CDS             1691..2389
                     /locus_tag="KNP36_003693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0875518.1"
                     /translation="MEKKYFEIHGVPSILWGNPSSKLYIYIHGQCGNKEEAEAFANIA
                     VPHECQVLSVDLPEHGERKREKNSFNPWHVVPELVSIMEYAKCHWNQISLYANSIGAW
                     FSMLSFEKENLRECIFVSPILDMQQLISNMMLWANVSEEQLKHELIIPTSFGHTLSWE
                     YLQYVKQHPITQWNVPTKILYGKHDELTEIGVVEKFVEKFNCNLTIIENGKHWFNTPQ
                     ELNSLYEWLNTLVK"
BASE COUNT          958 a          322 c          310 g          966 t
ORIGIN      
        1 ataattaaaa taataataaa ggtgttgttt ataatgttca aagaatactt aataagagaa
       61 ttaaaagaag atgatattaa aaatgcatta gacttaatct ggaacgtatt tgaagaattt
      121 gaatctccag attattgtga tgaaggaatt acgacatttc atcaatttat agaatataac
      181 tctattattg aaaaaatcaa agaaaaaact ctcttctttt ggggttgttt tgactctaaa
      241 aaacttattg gagtcttagc tattagaaat ttaaatcata tatgtatgtt atttgtagat
      301 aaaaactatc ataaacatgg tgttgcaaaa aaattaatga ctacaggcat acaatactgt
      361 atttgtaata aatttaattt aactgaaata actgtaaatt catcacctta tgctgttgaa
      421 gtttatcata aattaggatt taaagatact gctgttgagc aaattgttga cggtatacgt
      481 tttacaccta tgaaattgtt aatataataa attaaataaa aagcaaagtc tcttaaatat
      541 tttatagtta ctttgctttt aaaccaagat ttaaaataat actatctttt ttgtttttta
      601 ataatatact ttaaaatcct tactaatatg aactataatt tattttttga tatccttttt
      661 gattaacata taaattaatt caattattaa acataaacta tgttgtttct ctttatatct
      721 cttctttgta aacaatattg ggcatttgaa aataaatatt cttaaaatat actgttctcc
      781 tgttgatttt cctttggtac aaatgataaa aatttaattt acatgcccca taatgaagtg
      841 ttcaataaat aagttaaaat aatttattta cctccttaat catatttttt atgaatacct
      901 aataacacag tatcaataga atcggctaaa ccttttatag cttcttcttt actcaaaagt
      961 gatttcccaa gttgcaaagt cgaataacca tgaagtacac tcattattaa gtttaatact
     1021 tcacctgtat tctttgtatt tagattacaa gaaagaataa gtttttctaa taaggattta
     1081 tattcatcaa agatttctaa tgtttcatta tttccatgcc aagtagccca ctgaattgtt
     1141 tcataaacac caggattaga aattataaaa ttaaagtatg ctatacttat acactttata
     1201 gctgtatctc caaaatttcc aatagtcgcc tttatcattt gactattcat ctctctcatt
     1261 cctttatgag ctacttcaag taataaatca tctagacttt ctatatgatt gtacaaagat
     1321 ggtgtacgta ttcctagctt ttctgcaata acttttaaag aaactttgtt aagcccatct
     1381 ttattaacta tatctgatgt agcttgtata actatttctc tactaacacg catgattttc
     1441 cctctttcat ttaaaattaa ttactttatt agtttagcta atctaattag tttcgtcaat
     1501 tattgtaatt tataaaattc tttatactat tataaaatct tgacagttta attataattt
     1561 aatataatac taattgaatt agttttaata ctaatataat tagtattata ttaaattcta
     1621 tattacaaca ttattttata gtttgattaa tttaacaatc actaatatat caaactgaaa
     1681 ggagattttt atggaaaaaa aatatttcga aattcatgga gttccttcaa tcctttgggg
     1741 aaatccttca agtaaattat atatttacat acatggacaa tgtggcaata aagaggaggc
     1801 tgaagctttt gctaatattg cagttccaca tgagtgtcaa gttttaagtg ttgatttgcc
     1861 tgaacatgga gaacgtaaaa gagaaaaaaa ttcatttaac ccatggcatg ttgttccaga
     1921 attagtatct attatggaat atgcaaagtg ccactggaat caaatttcgt tatatgcaaa
     1981 tagcattgga gcatggttta gtatgttaag ctttgaaaaa gagaacttaa gagagtgtat
     2041 ttttgtatct ccaattctag atatgcaaca gctcatttca aatatgatgc tttgggcaaa
     2101 tgtatcagaa gaacagctta aacatgaact aattatccca acttcatttg ggcatactct
     2161 ttcatgggaa tatctacaat atgtaaaaca acatcctatc actcaatgga atgtaccaac
     2221 aaaaatatta tatggtaaac atgatgaact tactgaaatc ggtgttgtag agaaatttgt
     2281 agaaaagttt aattgcaacc ttactattat agaaaatggc aaacattggt ttaacacacc
     2341 acaagaatta aattcattat atgaatggtt aaatacttta gttaaataaa aaataattat
     2401 attattaata tgattaaatt atttataaat gttatttaat taattttatt ttagcattat
     2461 taaaataact acataaagaa taaattagtt attattaaag aaattaaaag tatatagagt
     2521 attaataatt ttttaataat tagttattat agaaaa
//
LOCUS       DAEHWM010000193         2530 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.196, whole genome shotgun sequence.
ACCESSION   DAEHWM010000193 DAEHWM010000000
VERSION     DAEHWM010000193.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2530)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.196"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            322..1311
                     /locus_tag="KNP36_003694"
     CDS             322..1311
                     /locus_tag="KNP36_003694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HBF0875519.1"
                     /translation="MLKEEKTYQEKDAKVFNGVAALIMILLFLVVSIGIMVFGIVKLD
                     SGFTGIGSLMLILGLVFIVVDFILFFGLKMINPKEAIVLVLFGNYYGTIKKEGYYWVN
                     PFCSAINPAVSRINVSKSSSDEKVDISTNSRGKKVSLKTMTLNNEKQKVNDLLGNPII
                     IGVVVIWKVIDATKAVFNVDNYNTFLSIQCDSTIRNVSRLYPYDVSEDGDEKSLRGSS
                     QEIADRLKDELQSRVDIAGIEVCEVRITHLSYAPEIAAAMLQRQQAEAIIAARKKIVE
                     GAVSMVEMALTNLSENNVVTLDEERKAAMVSNLLVVLCGNKDAQPVVNSSSIY"
     gene            complement(1763..2479)
                     /gene="dapD"
                     /locus_tag="KNP36_003695"
     CDS             complement(1763..2479)
                     /gene="dapD"
                     /locus_tag="KNP36_003695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HBF0875520.1"
                     /translation="MVNLNDAYEIARYIKEVKKKTPVKVYVNTNSLHFQSTDKFKVFG
                     SNGSYIFVGDYEDIMEVLDKHGNDITDTHVEYDRRNSAIPLKNTLSEHARIEPGAIIR
                     DMVTIEKNAVVMMGAVINIGAVIGEGSMVDMNAVIGARGTLGKNVHLGAGAVVAGVLE
                     PPSATPVIVEDDVLIGANAVILEGVRIGKGAVVAAGAVVTTDVEAGAVVAGSPAKVIK
                     MKDEKTADKTKLMEDLRNLD"
BASE COUNT          936 a          325 c          378 g          891 t
ORIGIN      
        1 aaaaatttaa gtggattttt caaaatatag ataaatttct ttttcattgt ataaatgata
       61 aaaatatatt tgacttcata ccaaaaagag tgccccatga actaaaaagt taattttgaa
      121 ataccatatt catatatcat atgatttatt tggaaatcaa tattaataca ttaaaataac
      181 taaatacatg tatgcataaa gatgtataaa aaatatataa acatatagta ttaattttaa
      241 attcaacaat ttaattgtta aaagtgttat tattaaatta gaaatatctt aacttaatat
      301 actgagatgg gagtgataga tatgttaaaa gaagaaaaaa cttatcaaga gaaagacgca
      361 aaagtattca atggagtggc agctttgata atgattttat tatttttagt agtttcaata
      421 ggtatcatgg tttttgggat agtaaaactt gatagtggat ttactggaat aggttcactt
      481 atgttaattt tgggacttgt atttatagta gtagatttta tcctattttt tgggctaaaa
      541 atgattaatc ctaaagaagc tatagttcta gttttgtttg gtaactatta tggaactata
      601 aaaaaagaag ggtactattg ggtgaatcca ttttgttcag caataaaccc agcagtatca
      661 agaattaatg tatcgaaatc ttcatctgat gaaaaggtag atatatcaac taattcaagg
      721 ggcaaaaaag tatctttaaa aacaatgact cttaataatg aaaagcagaa agtcaatgat
      781 ttattgggaa atccaattat aataggagtg gttgtaattt ggaaggttat agatgcaaca
      841 aaggcagtat ttaatgtaga taattataat acattcttat ctattcagtg tgattctact
      901 attcgcaatg tttcaagact ttatccatat gatgtatctg aagatggaga tgaaaaatct
      961 cttcgtggta gtagtcagga aatagcagat agattaaaag atgaattaca atcaagggtt
     1021 gatattgcag gaattgaagt gtgtgaagtg agaattactc atctttctta tgcaccagag
     1081 attgcagcag caatgttaca acgtcaacaa gcagaggcta taatagcagc acgtaaaaag
     1141 attgttgagg gggctgtaag tatggtagag atggcattga ctaatttaag tgaaaataat
     1201 gttgtgactt tggacgaaga acgtaaagca gctatggtaa gtaatctgtt agttgtgctt
     1261 tgtggcaata aagatgcaca accagtggta aacagcagtt ctatttatta aattataaaa
     1321 agtttaatag tttattttat tgatatatag aaaatttagt agttcatttt attaaattat
     1381 agaaagatta atggtttgct ttattgaatt ataaaaagtt taataattta ttctattgat
     1441 atatagaaaa tttagtagtt cattttatta aattatataa agattaatgg ttttcacttt
     1501 attaaattat aaaaagttta atagtttatt acattgatat attgaaaaat tgaaggaaat
     1561 aaaaatactt gtcagcaaga aataaaaatg atataagaat gaataagaga attgtaaaaa
     1621 aataaaatga ttataaataa aagataaaaa tattgtaaaa aagagggtgc ctctggtgaa
     1681 ttaaattcac acagagacac ctttttaatt aattttttaa attagtatat tattgtttaa
     1741 ttaatagtat agtactattt aattaatcta aatttctaag gtcttccata agcttagttt
     1801 tgtcagccgt tttttcatct ttcattttta taactttagc aggagaacca gcaacaacgg
     1861 caccagcttc tacatcagta gttacaacag caccagctgc aacaacagca cctttaccga
     1921 ttctaacacc ttcaagaata actgcattag ctcctattaa aacatcatct tcaactataa
     1981 caggagtagc agaaggtggc tctaaaacac cagcaacaac agcaccagca cctaagtgaa
     2041 catttttacc aagagttcct ctagctccaa taacagcatt catatctacc atagaacctt
     2101 caccaataac agctcctata tttataacag ctcccatcat tacaacagca tttttttcta
     2161 tagtaaccat gtctcttatt attgcacctg gctcaattct tgcatgttca cttaaagtat
     2221 tttttagagg aatagcagaa tttcttctat catattctac atgagtatct gttatatcat
     2281 ttccatgttt atctaatact tccattatat cctcatagtc acctacaaat atataagaac
     2341 cattacttcc gaatacctta aatttatcag ttgattggaa gtgtaaagag ttagtattta
     2401 catatacctt aacaggtgtt ttctttttaa cttcttttat ataccttgct atttcataag
     2461 catcgtttaa atttaccatt tgttaattct ccttgtattt cattatattt cttttattat
     2521 atacttattt
//
LOCUS       DAEHWM010000194         2521 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.197, whole genome shotgun sequence.
ACCESSION   DAEHWM010000194 DAEHWM010000000
VERSION     DAEHWM010000194.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2521)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.197"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(27..290)
                     /locus_tag="KNP36_003696"
     CDS             complement(27..290)
                     /locus_tag="KNP36_003696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875521.1"
                     /translation="MIKNTKQITVEVNEILLQEMSKITNDENNILTDLINESIVNYIL
                     ENKKHNIENKDLEEVIKFYKKENTEKPKSAARAIAEAKTHTLY"
     gene            606..1181
                     /locus_tag="KNP36_003697"
     CDS             606..1181
                     /locus_tag="KNP36_003697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875522.1"
                     /translation="MKLKEALITCVVCSVCLTPLLVNGETKIDADHCKESIVNIDTIV
                     KSGKSFNSKYNQGMEDYKNSDEYKLKVQKEKLQNQLGIKIKKLVPITFEVSYYTSLNQ
                     ENGYGAITATGDDLEDGFVANNHLSFGTKIIVDGKLKTVMDRGSSKYFSNSNAIDVFV
                     PKWSNESESEYYDRVNNMGRHYKKGYIIVEE"
     gene            1279..2277
                     /locus_tag="KNP36_003698"
     CDS             1279..2277
                     /locus_tag="KNP36_003698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4003 domain-containing protein"
                     /protein_id="HBF0875523.1"
                     /translation="MEQSFINGKVNLLIENYKALNEVKGSWQMGLIQHSCALAFTLKN
                     KRISPRLVEERIELIKKNTGLFSNFRGYNMFYMATLLSFESNPESSFKMILDIYKELK
                     SEKFWGDTYLPLTASIVYENREKMDYLTCISKMKIIYDYMRKKHPFLTSSDDYCNIAL
                     IAIHSKNLDEDLEYIEKCYEFLNENGFYKGNDLQALSQILLFSDDRTMLKCKKTIELK
                     KAFKENDCKMNYYGYPIIGAISLLDYREDEIIEEIKNVSNKLKEEKGFGNWSLGKSNR
                     VMISSAIVASIYADLIRNENNIGSITNNIFLNIVVAIQIACVMAATSAAIASSSSN"
BASE COUNT         1013 a          226 c          389 g          893 t
ORIGIN      
        1 tagtttttag gaactttttt atttgattaa tacagagtat gagtttttgc ttcagctata
       61 gctcttgctg cacttttagg tttttcagta ttttcttttt tgtaaaattt aatcacttct
      121 tctaaatctt tattttcaat attatgtttt ttgttttcaa gaatataatt tacaattgat
      181 tcatttatca aatctgtcaa aatattattt tcgtcattag ttatcttaga catttcttgt
      241 aataaaattt cattaacttc tactgtaatt tgttttgtat tttttatcat atcaaccacc
      301 tcttaagaaa attatatcat ctcaaaaaaa taaattcaat atgttttaaa attatagaat
      361 tttaattctt aaattctaaa aaagagaaaa ttagataaag tagttttaga ttttaaaaga
      421 ttaataaaaa atatttaaag ataaaagctt tattctatat gattctaaga tagaggattt
      481 ataagtgttt aaggtgaatt aaatataaga caacttctta aagcaaatgg gtgtggtatt
      541 taaatctaaa tgtagacata taatattaaa tatgctaata tatcaaaata ataagggggg
      601 aatttatgaa gcttaaagaa gcattgatta catgtgttgt atgtagtgta tgtttaactc
      661 cattattggt aaatggagaa acaaaaatag atgcagatca ttgtaaagaa tctatagtaa
      721 atatagatac tatagtaaag tcaggtaaaa gctttaattc caagtataat caaggtatgg
      781 aagattataa aaatagtgat gagtataagt tgaaagtaca aaaggagaaa ctacaaaatc
      841 agttaggtat taaaataaag aagttagtac ctataacttt tgaagttagt tattacacaa
      901 gtcttaatca agaaaatgga tatggagcga taactgctac aggagatgat ttagaagatg
      961 gttttgtagc aaacaatcac ttaagttttg gaactaagat tattgtagat ggaaaattaa
     1021 aaactgttat ggataggggg tctagtaagt attttagtaa ttctaatgca atagatgtat
     1081 ttgtgcccaa atggagtaat gaaagtgaat cagagtacta tgatagagtc aataatatgg
     1141 gaagacatta caaaaaaggc tacattattg ttgaagaatg atgttctttg aagtaatatg
     1201 tattgattgt agtatttaat atatatataa taaatataaa actattagta caatgagata
     1261 tattactagg agggcaatat ggaacaatcg tttataaatg gaaaagtaaa cttattaata
     1321 gaaaattaca aagcattaaa tgaagttaaa ggttcttggc aaatgggatt gatacaacat
     1381 agttgtgcac ttgcatttac ccttaagaac aagagaataa gtcctagatt agtggaagaa
     1441 cgaatagagc ttattaaaaa aaatactgga ttattctcta attttagagg atataatatg
     1501 ttttatatgg caacactact ttcgtttgaa tcaaatccag aaagtagttt taagatgatt
     1561 ttagatatat acaaagaact taaaagtgaa aagttttggg gcgatacata tttaccactt
     1621 acagcatcaa tagtttatga aaatagagag aaaatggatt atcttacatg tatatcaaaa
     1681 atgaaaataa tatatgatta catgaggaaa aaacatccat ttctaacttc tagtgatgac
     1741 tattgtaata tagcacttat tgcaattcat tcaaaaaatt tagatgaaga tttagaatac
     1801 atagaaaaat gttatgaatt tctaaatgaa aatggttttt ataaaggaaa tgatttacaa
     1861 gcattatccc aaattctttt atttagtgat gatagaacta tgcttaaatg taaaaagact
     1921 attgaactta aaaaagcatt taaagaaaat gattgtaaaa tgaattatta tggatatcca
     1981 ataataggag caatttcatt attagattat agagaagatg aaataataga agagataaaa
     2041 aatgtttcaa ataaacttaa agaagaaaaa ggctttggaa attggtcttt aggaaaaagt
     2101 aatagagtaa tgattagttc tgctattgta gcttcaattt atgcagattt gatacgaaat
     2161 gagaataata taggctctat aactaataat atatttttaa atattgttgt tgctattcaa
     2221 attgcatgtg taatggcagc aacaagtgca gctatagcat cttcttcatc aaattaataa
     2281 gatttattga agttggatat attaaattta ataatacaat ttatatgttt aaaaagaaga
     2341 tagtattaca ttttaattaa ctgtgatatt atataatatg aaacatataa ttaatatata
     2401 gattttaggc aataaatact acatacaata tagggaaagt agaatagtac atctactttc
     2461 cttttttgat tgagtaagtt attttggaaa aaattatgta aaactattta agttttatat
     2521 t
//
LOCUS       DAEHWM010000195         2470 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.198, whole genome shotgun sequence.
ACCESSION   DAEHWM010000195 DAEHWM010000000
VERSION     DAEHWM010000195.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2470)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.198"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(128..2173)
                     /gene="bclA1"
                     /locus_tag="KNP36_003699"
     CDS             complement(128..2173)
                     /gene="bclA1"
                     /locus_tag="KNP36_003699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="collagen-like exosporium glycoprotein BclA1"
                     /protein_id="HBF0875524.1"
                     /translation="MRNIILYLNDDTFISKKYPDKNFSNLDYCLIGSKCSNSFVKEKL
                     ITFFKVRIPDILKDKSILKAELFIHIDSNKNHIFKEKVDIEIKRISEYYNLRTITWND
                     RVSMENIRGYLPVGISDTSNYICLNITGTIKAWAMNKYPNYGLALSLNYPYQILEFTS
                     SRGCNKPYILVTFEDRIIDNCYPKCECLPIRITGPMGPRGATGSTGPTGVTGPTGSTG
                     ATGSIGPTGPTGNTGATGSIGPTGVTGPTGSTGATGSIGPTGVTGPTGNTGVTGSIGP
                     TGATGPTGNTGVTGSIGPTGVTGPTGNTGEIGPTGATGPTGVTGSIGPTGATGPTGEI
                     GPTGATGATGVTGSIGPTGATGPTGATGVTGEIGPTGEIGPTGATGPTGVTGSIGPTG
                     ATGEIGPTGEIGPTGATGPTGVTGSIGPTGATGPTGATGEIGPTGATGPTGNTGVTGE
                     IGPTGATGPTGNTGVTGEIGPTGATGPTGVTGEIGPTGNTGATGSIGPTGVTGPTGAT
                     GSIGPTGATGATGVTGPTGPTGATGNSSQPVANFLVNAPSPQTLNNGDAITGWQTIIG
                     NSSSITVDANGTFTVQENGVYYISVSVALQPGSSSINQYSFAILFPILGGKDLAGLTT
                     EPGGGGVLSGYFAGFLFGGTTFTINNFSSTTVGIRNGQSAGTAATLTIFRIADTVMT"
BASE COUNT          557 a          558 c          380 g          975 t
ORIGIN      
        1 ttttatgaat atattttatt attattgtta ttttattcat tctaaaatag gtaaaactca
       61 atatataaaa atacttttgt catttaaata aagcctaaat agtttttaag attattttag
      121 acacgtttta agtcataaca gtatcagcta ttctaaatat cgtcaaagta gccgcagttc
      181 ctgctgattg cccatttcgt atccctactg ttgtagatga aaaattattt attgtaaaag
      241 tagtcccacc aaataaaaaa ccagcaaaat atccagaaag tactcctccg cctcctggct
      301 cagtagtaag ccctgccaaa tcttttcctc ctaaaattgg gaataggata gcgaaagaat
      361 attgatttat acttgatgaa cctggttgta atgctactga aactgatata taatacacac
      421 cattttcttg tactgtaaac gtaccatttg catctactgt tatacttgaa ctatttccta
      481 ttattgtttg ccaacctgtt atagcatctc cattatttag tgtttgtgga gatggtgcat
      541 ttacgaggaa gttagcaact ggctgagagg aattgcctgt tgctcctgtt ggacctgttg
      601 ggcctgttac tcctgtcgct cctgttgctc ccgttggtcc tatacttcct gtcgctcctg
      661 ttggacctgt tactcccgtt ggccctatac ttcctgtcgc tcctgtattt cctgttggcc
      721 ctatttctcc tgtcactcct gttgggcctg ttgctcccgt tggtcctatt tctcctgtca
      781 ctcctgtatt tcctgtcgga cccgttgctc ccgttggtcc tatttctcct gttactcctg
      841 tatttcctgt tggacctgtt gctcccgttg gtcctatttc tcctgtcgct cctgttgggc
      901 ctgttgctcc cgttggtcct atacttcctg tcactcctgt tgggcctgtt gctcctgttg
      961 gtcctatttc tcctgttggt cctatttctc ctgtcgctcc cgttggtcct atacttcctg
     1021 tcactcctgt tgggcctgtt gctcccgttg gtcctatttc tcctgttggc cctatttctc
     1081 ctgtcactcc tgtcgctcct gttggacctg ttgctcctgt tggtcctata cttcctgtca
     1141 ctcctgtcgc tcctgttgct cccgttggtc ctatttctcc tgttggtcct gttgctcctg
     1201 ttggtcctat acttcctgtc actcctgttg gacctgttgc tcccgttggt cctatttctc
     1261 ctgtatttcc tgttgggcct gttactcctg ttggtcctat acttcctgtc actcccgtat
     1321 ttcctgtcgg gcctgttgct cccgttggtc ctatacttcc tgtcactccc gtatttcctg
     1381 tcggacctgt tactcctgtt ggtcctatac ttcctgtcgc tcctgtactt ccggttgggc
     1441 ctgttactcc cgttggccct atacttcctg ttgctcctgt atttccggtt gggcctgttg
     1501 gtcctatgct tcctgtcgct cctgtacttc cggttgggcc tgttactccc gttggtcctg
     1561 tacttcctgt cgctcctctt ggtcccattg gacctgtaat tctaattgga agacactcac
     1621 atttaggata acaattatct ataattctat cttcaaatgt tacaagtata tacggtttgt
     1681 tacaacctct actagatgta aattcaagaa tctgataagg gtaatttaaa gataaagcta
     1741 acccataatt aggatattta ttcattgccc atgcttttat agttcccgta atatttaaac
     1801 aaatatagtt ggatgtatca cttatcccaa ctggtaaata tcccctaata ttttccatag
     1861 acactctatc attccatgtt atagttcgta aattataata ttcacttatt cttttaattt
     1921 caatatctac tttttcttta aaaatatgat tcttatttga atcaatatga ataaataact
     1981 ctgcttttaa tatacttttg tcttttaata tatctggtat tctcacttta aaaaaagtaa
     2041 tcaacttttc ttttacaaaa ctatttgaac atttacttcc tattaagcaa taatctaaat
     2101 tactaaagtt tttatctgga tattttttag atataaaagt atcatcattt aaataaagta
     2161 taatatttct catttataat ccctccattt tgggtctata tcatactatg tttaaaatac
     2221 atgcttagtt acaatataat taaaatttat agtattaaat ttttatataa taatgctgat
     2281 ttctacaaaa aaagaacatg tcattagaaa tttctaatag catgttcttt ttcattatta
     2341 tatattacac tttaaattat tccttgactg gcttagctgg tgtaaactaa accagtcttt
     2401 ctaaaatatt aagcactttt ttcttattat gttttttagg atttattgtc tatattattg
     2461 taaaccaaag
//
LOCUS       DAEHWM010000196         2426 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.199, whole genome shotgun sequence.
ACCESSION   DAEHWM010000196 DAEHWM010000000
VERSION     DAEHWM010000196.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2426)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2426)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2426
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.199"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            243..383
                     /locus_tag="KNP36_003700"
     CDS             243..383
                     /locus_tag="KNP36_003700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875525.1"
                     /translation="MEKSNTTVTKKEKIEDIGMKLEHLLSEDITFYELLLEILYKEKE
                     EN"
     gene            complement(380..751)
                     /locus_tag="KNP36_003701"
     CDS             complement(380..751)
                     /locus_tag="KNP36_003701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875526.1"
                     /translation="MESLGDRIANLRKELDINQKELATKVGITEASLSRYENNLREPK
                     SEIIVRLAKALETSTDYLLGVNDNTKISKEDKLIIENLSVSEKTKKLLEKIYSLEKED
                     REAIEKMIDNAYLKRFLKEEN"
     gene            1300..1557
                     /locus_tag="KNP36_003702"
     CDS             1300..1557
                     /locus_tag="KNP36_003702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003428911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875527.1"
                     /translation="MIIIRSQDKTNLMQINQIKIDGSQVYAVFESKIDTVKIGDYENN
                     TRAIQVLDNIQNFIENGTKYDYITSNKVRYNVNKIFQMPAK"
     gene            complement(1667..2347)
                     /locus_tag="KNP36_003703"
     CDS             complement(1667..2347)
                     /locus_tag="KNP36_003703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HBF0875528.1"
                     /translation="MIWTFYSFICVILPCLIYQIVVIKRKNLKVEKNVMIHLVWVYIF
                     LLYIYLALSKAGIGSIWDIGRYSGLFRIDEINLIPFDSVGILTYILNIIMFMPLGFLL
                     PLIWKNFRNIINVSLTGLGFSLAIELCQLFNLRATDIDDLMMNTLGAVLGYFIWVGVN
                     NLFNLIKKKDIFPSIYKNIIQDEIAITIDDDISKKITSLYKNEAIIYLILAVLGEFLL
                     FNWSIIPY"
BASE COUNT          983 a          267 c          276 g          900 t
ORIGIN      
        1 ataaaaatag aaaaaacata caagattcta caataataga tttttttgtt attattacga
       61 gttttttatt gcaactgtag aataaaagta ttattatata attaagataa ttatctaggg
      121 aaattttgga taatcaaaat atattttata aaatcaaaat acaattacat aaactttatt
      181 aaaaatttgt tgggaatttc tgactaacat taagaacgta agtttgttgg gggatggtat
      241 atgtggaaaa gtcaaacact actgttacaa aaaaagaaaa aattgaagat ataggaatga
      301 aattagaaca tttattgagt gaagatatta ctttttatga attattactt gagattttgt
      361 ataaagaaaa agaagagaat taattctctt ctttaaggaa tctttttaaa taggcattat
      421 caatcatttt ttctatagct tctctatctt ctttttcaag agaatatatt ttttctaaga
      481 gcttttttgt tttttcactt actgataagt tctctatgat taatttatct tctttgctta
      541 tttttgtatt atcatttacg cctaataaat aatctgttga tgtttctaat gcttttgcta
      601 atctaactat tatttcactt ttaggttctc ttaaattatt ttcataacgt gacaagctag
      661 cctcagttat accgacttta gtagcaagtt ctttttgatt tatatctaat tcttttcgta
      721 gatttgctat tctatctcct aaactttcca tatgtacatc actccttacc gaaattataa
      781 gttattttga taaaaagtaa aataaaatta ccaaaaatat aaaaaaaaaa ggttaaaata
      841 ataaaatata ttgaaaatta ccatttgtat atgtataata tgaattatac aaatggtaat
      901 ttgatgagag gtggtatgtt gaaataagaa actgaattaa ttaataaata catagaaagt
      961 tttgaaaacc tttaattgag atataaacaa tatgtacaaa attttttgca agtaaaatta
     1021 ccaaatgtat aaaataaatc agtagcatag ataattttat gttttaatac attagattat
     1081 ttaatttagt tataatggtc aaaaatgcaa tctacaaata aaacaaagta ttatcaaaaa
     1141 agtattcttt aagaaaattt tttattagag atgtaattga tataaataat cgtattaaaa
     1201 aataaaatac taagtttaaa aatttaaata atctataaat caattataaa atattattta
     1261 ttagaaatta aaatgaatta agtaaatgga ggaattgata tgataataat tagaagtcaa
     1321 gataaaacta atttaatgca gataaaccaa attaaaatag atggtagtca agtttatgca
     1381 gtatttgaaa gtaaaattga tactgtaaaa ataggagatt atgaaaataa tacaagagct
     1441 atacaagtgt tggacaatat acaaaacttc attgaaaatg gaacaaaata tgattatata
     1501 acatcaaata aagtcagata caatgttaat aaaatatttc agatgccagc taaatagtga
     1561 gtgtgcattt taatttaata actaaagccc actttctttt gtagtatgaa agagggcttt
     1621 acatatttgt aaatatcgaa gtacacttat tttatcaata aattatttaa taaggtataa
     1681 tggaccaatt aaacaataaa aattctccta aaacagcaag tattaaatat ataatagctt
     1741 catttttgta aagagaggta atttttttgc ttatgtcatc atcaattgta atagcaatct
     1801 catcttgaat aatattttta tatatagatg ggaaaatatc ttttttcttt ataagattaa
     1861 ataaattatt tacacctacc catataaaat atcctaaaac agcacctaat gtgttcatca
     1921 ttaaatcatc aatatctgta gctcttaagt taaacaattg acaaagttca attgctaatg
     1981 aaaaacctaa tccagttaat gaaacattga taatatttct aaaatttttc caaattaaag
     2041 gtagtaaaaa tcctaaaggc ataaacataa ttatatttaa aatatatgtt aagatgccaa
     2101 ctgagtcaaa aggtattaga tttatttcat caattctaaa aagcccacta taccttccta
     2161 tatcccatat gctaccaatt ccagctttac taagtgctag atagatatat aataaaaaaa
     2221 tatataccca tactaaatgt atcattacat tcttttcaac tttcaaattt tttcgtttta
     2281 taacgactat ttggtatatt aagcatggta atataacgca aataaatgaa taaaatgtcc
     2341 atatcatttt attttgtccc ctttcaaatt tatgttttta gttttataag tactatcttt
     2401 atattaaact gtaagtttta aaaatc
//
LOCUS       DAEHWM010000197         2424 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.200, whole genome shotgun sequence.
ACCESSION   DAEHWM010000197 DAEHWM010000000
VERSION     DAEHWM010000197.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2424)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.200"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            269..2053
                     /locus_tag="KNP36_003704"
                     /pseudo
     CDS             269..2053
                     /locus_tag="KNP36_003704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011860844.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding repeat-containing protein"
BASE COUNT         1054 a          327 c          435 g          608 t
ORIGIN      
        1 atacaaaacc ctatttttta taacaattca ttaacataaa aatcaaactt accttaaaat
       61 ataaatttac aaatttttca atcaataaga aaatttcttt attccttaca taatgactgc
      121 aatgtaacaa aataattaca aattaattat gaaatcatta tagttagaaa cctctttaaa
      181 attagatatt aagtatcctt tagaattaga acgggaacaa agttaaaaaa ttaagtaata
      241 tcaaatggac aagggggaag aaaataaaat gaaaatacca aagaagattg ctgcaatgct
      301 tacagttaca atgatagctg gaagttcaac agcaggcata gctagtgcac aaactgtggc
      361 aacaaattta acagggcaag aaagatatga aactgctgtt aaaataagtc aagatggatg
      421 gaaaaatgct gatgaggtag taatcgtaaa cgactcatct atagcagatg ctctatctgc
      481 aacaccattt gcaaaagcaa aaaatgctcc aatactttta acaagtaaag ataaattaaa
      541 tgataagacg aaagcagaaa tacaaagatt aaaagctaaa aaagtatact taataggtgg
      601 aacttctgta ttaagtacaa atatagaaaa agaaataaaa gatttaaaaa tatcttttga
      661 gagaatctct ggagctgaga gatatcaaac atccttagaa ttagcaaaga aattagatgc
      721 tataagtgat gttaagaaaa tagctgtagt taatggtgaa aaaggacttg cagatgctgt
      781 aagtgtagga gcaccagctg cacaaaacaa tatgccagta atacttgctg attctaaaaa
      841 tggaacagca gttgcagaca aatttataaa ggatgctgga ataactcaat cttatgtagt
      901 aggtggagag agttcaattt ctgaagctgt taaaaataaa ctaccaaata gtacaagact
      961 aggtggaaca gatagaaatg atacaaatgc aaaagtaata aaagaatttt ataaaaagac
     1021 agatttaaaa aatgcttatg taactaaaga tggtatgaat aaacaagacc aacttataga
     1081 tgcactagca gtaggtgtat taggtgctaa aaatcaatca ccagtagttt tagttggaaa
     1141 gaacttatca gcttcacaaa aatctctagt taactctaag agttttgata agataactaa
     1201 agttggtggg aatggtaatg agacagcatt taatgaaatg aagtcattac aagaagtaaa
     1261 aacagttgaa gctaaaacaa tttctgaatt aaaatcagct atagataaag ctactgctaa
     1321 tgatgttata aactttaagc caactagtga ggttaaagaa gcatttacaa tacaaactga
     1381 taaagcagta acagtaaact taaatggtac atatacaaag actgtgacta tcaacatgcc
     1441 taatggtgat gtaaataact atgcaaaagt ggatgatgta gttatagatg atgtaaaaga
     1501 tggaactttt gttaattatg gaaaaataac taacttaaag gttaatgata aaaatggagc
     1561 caagatagaa aataattcta aaggtgagat tggtagttta acagtagcat ctggagcaag
     1621 tcaagtaaaa gtgactaatg gtggtaagat aactacagtt acaaataatt ctaaagggac
     1681 tactatagat aataaaggta caataagtag tgttaaggga gataattctc caacaataag
     1741 tggaaatagt ccaagttcta actcttcagg aggaagttca tcaagtggag gttcttcaca
     1801 tggaggaggc tcatcttcag gaggaagttc ttctaatcaa acatcagtaa ataatgaagc
     1861 agcaaaaata acaagcgtgc ctacaccagc aaaagatgca actagattaa ctatgccatc
     1921 agtatcaagt ggatatacta tagcaataaa aacatcaagt aatgagagtg ttataaaaaa
     1981 agatggaaca ataatacctc caaatacagc aacaacagta aaattagtat ttacggtaac
     2041 acatacatca agtggtaaaa cagcagatac aaaagaatta tctgtaacag taccagctaa
     2101 atcaacagat gaagaattac aagcagcatt agacaatgaa gtggcaaaaa taacaagcgt
     2161 tcctgcacca gcaaaagatg caactaaatt aactatgcca tcagtatcaa gtggatatac
     2221 tatagcaata aaaacatcaa gcaataagag tgttataaag gaagatggaa caataatacc
     2281 tccaaataca gaggaaacag taacattggt atttacagta acacaagaat caagtggtaa
     2341 aacagcagat acaggagaaa tagatgtagt agtaccagcc aaatcaacag atggggaaat
     2401 acaagcagaa gtacaagctg aggc
//
LOCUS       DAEHWM010000198         2070 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.201, whole genome shotgun sequence.
ACCESSION   DAEHWM010000198 DAEHWM010000000
VERSION     DAEHWM010000198.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2070)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.201"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            195..809
                     /locus_tag="KNP36_003705"
     CDS             195..809
                     /locus_tag="KNP36_003705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HBF0875529.1"
                     /translation="MEEVIAKIITIENGFKEIENIAKKIVKNNDSKKCYYLSIYLYRS
                     EYYQVRELAVFILGFISVTISEALLFLKDNVSKDENWRVQEILAKSFDYYCSEVGYEK
                     ALPVIKEWLNSDSPNIKRAVTEGLRIWTSRDYFKSNPDVAISLLSSLKEDDSEYLRKS
                     VGNALRDISKKYPDLVKKELDSWDISNKKVEFVYKLASKCILAK"
     gene            827..1189
                     /locus_tag="KNP36_003706"
     CDS             827..1189
                     /locus_tag="KNP36_003706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009898297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875530.1"
                     /translation="MKLRDEYTCPLELTHDMIKGKWKSIILWRLRIGPTSLSKLEKEI
                     NGINQKMLLEQLKELIEFGLVDKKTYEGYPLKVEYSLTPIRGKQILDALAIMQDIGIS
                     FMLDNGMEDILKEKGVLK"
     gene            1295..1792
                     /locus_tag="KNP36_003707"
     CDS             1295..1792
                     /locus_tag="KNP36_003707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003421940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="HBF0875531.1"
                     /translation="MKVTSTGIVNGVIEDKYGKRGTQFNEGGMPTYSLPLKFEDAPKN
                     TVSFAVFLEDKDSVPVCGFAWIHWLAVNITKDELNENESVTATDFVQGTTSWHGKLGG
                     LDRLEASVYGGMAPPDRPHVYEIHVFALDTILDLEKGFYMNEFFKAIEGHVLDTFTLK
                     GSYSN"
BASE COUNT          788 a          227 c          338 g          717 t
ORIGIN      
        1 ttataatata aaacttataa taaaagtaaa tttatatgtt aaatgaggtt gattttttat
       61 tattttttat ttatgctagt actaaagact tgcaaacgtt ttttgacaag tctttatttt
      121 gtctaaatta aacaaacttt tttacaaata aatacataaa atttaaacta atctatttat
      181 tggaggagat aaaattggaa gaagtaattg caaaaattat tactatagaa aatggattca
      241 aagaaattga aaacattgct aaaaaaattg taaaaaataa tgactcaaaa aagtgttatt
      301 atctatcaat ctacttatat aggtcagaat attatcaagt aagagaattg gctgtgttta
      361 tacttggttt tatatcagta actatttctg aagctttgtt atttttaaaa gataatgtga
      421 gtaaagatga aaactggaga gtacaagaaa tactagctaa atcatttgat tattattgca
      481 gtgaagtagg atatgaaaag gctcttcctg ttataaaaga atggcttaat tctgatagtc
      541 caaacataaa aagggctgtg acagaaggtc ttcgaatttg gactagtaga gactatttta
      601 aatctaatcc tgacgttgct atatcactac tttctagttt aaaagaagat gatagtgaat
      661 acttgagaaa gtctgtaggt aatgctctta gagatataag taaaaaatat ccagatttag
      721 taaaaaaaga attagattca tgggatatat caaataaaaa agttgagttt gtatataagc
      781 ttgcttcaaa atgtatcttg gcaaagtaaa atggaggtga acttatttga aacttcgtga
      841 tgagtatact tgcccattag aactaacaca tgatatgata aaaggcaaat ggaaatctat
      901 tatattatgg agattacgca taggaccaac ttccttatca aaacttgaaa aggaaatcaa
      961 tggtattaat caaaagatgt tacttgaaca acttaaagaa ttaattgaat ttggtcttgt
     1021 agataaaaag acatatgaag gttacccact taaagttgaa tactcactta cacctattcg
     1081 agggaaacaa atattggatg ctttggctat aatgcaagat ataggaatta gctttatgtt
     1141 ggataatggt atggaagata ttcttaagga aaaaggtgtt ttaaaataaa tagataccca
     1201 caaaaaagta agtaatttac cattattttc aactggtata taattaaatt atagatatat
     1261 tctattaatt tattataata ggaggtaaat tattatgaaa gtaactagta caggtatagt
     1321 aaatggtgtt atagaagata aatacggtaa aagaggaact cagttcaatg aaggtggtat
     1381 gcctacatat tcactacctc taaagtttga agatgctcca aagaatacag tatcctttgc
     1441 tgtattttta gaagataaag actctgttcc tgtatgtggg tttgcatgga tacattggtt
     1501 agctgtaaat ataacaaaag atgagttaaa tgaaaatgaa agtgtaacag ctactgattt
     1561 tgtacaaggg actactagtt ggcatggcaa actaggaggt cttgacagat tagaggccag
     1621 tgtatatggt ggaatggctc ctccagacag acctcatgtc tatgaaatac atgtatttgc
     1681 acttgatact atccttgacc ttgaaaaagg attctatatg aatgaatttt tcaaagctat
     1741 tgaagggcat gttttagata catttacact aaaaggaagt tattctaatt aattaggttg
     1801 actatagcta atcattaatt aaatgctaca tttaattgat gattagctta attgttatta
     1861 gaatattttc tgcactttat cttaatatat attttagttg actggtattt taatttctat
     1921 tagattatta tcaatttata taaattgatt ttagcttaaa acttacttat ctatttcagt
     1981 ttctattaga attattatta gactcattaa aataaaagca ctaatataac taataatata
     2041 tgttaaattc attaactcta cataaagttt
//
LOCUS       DAEHWM010000199         1992 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.202, whole genome shotgun sequence.
ACCESSION   DAEHWM010000199 DAEHWM010000000
VERSION     DAEHWM010000199.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1992)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1992)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.202"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            17..415
                     /locus_tag="KNP36_003708"
     CDS             17..415
                     /locus_tag="KNP36_003708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875532.1"
                     /translation="MNKKKKLIGIAISFLLIISIINPLQVEAEAIIESSVYISSIKEN
                     YTYDNTKFKTIKSKSRHKSRKYNKSKVKLKKRSIRTKKYGYQTINKYKRQNARRHNIL
                     TKLILSIIVIFLVIVLVVLIFIKRKKKKFY"
     misc_binding    851..1114
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            1265..1816
                     /locus_tag="KNP36_003709"
     CDS             1265..1816
                     /locus_tag="KNP36_003709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan transporter"
                     /protein_id="HBF0875533.1"
                     /translation="MKTNTKKLTLNAILLAMGLLIHQITPAIGLPMKPDVPLAMLFVI
                     LVLNRDDYKTCLIAGIVTGIFTALTSSFPGGQIPNVIDKTLTANIVFLLMNISYNMPF
                     IKKLAKKTQDTVVVAIIMPIGTLVSGTIFLLAAQAIVGLPGASFTALFLAVVLPAVLI
                     NLVAGIFLFKIVSLSIRRVSYQA"
BASE COUNT          838 a          192 c          295 g          667 t
ORIGIN      
        1 ttatgagggg gaaaatatga ataagaagaa aaaattgatt gggatagcta tatcttttct
       61 acttataatc agcattataa atccattaca agtagaagca gaagctatta ttgagtctag
      121 tgtatacatt tcttcaataa aagagaatta tacatatgat aatactaaat ttaaaactat
      181 taaatctaaa agtagacata aaagtaggaa atataataaa agtaaagtaa agttgaaaaa
      241 acgaagtata agaactaaaa agtatggata tcaaactata aataaatata aaagacaaaa
      301 cgcaagaaga cataatatcc taacaaaatt aatattgtcc ataatagtca tatttttggt
      361 tatagtttta gtagtgctaa tatttattaa aagaaagaag aaaaaatttt actaaaaata
      421 attaaaagaa tatcattttt ttaatcattg gtatctattt aataatatga tgtaattaaa
      481 atggagtaat attctgtttc aaaggaggca tataaataca ggaatgagta ttaaatgatg
      541 gttaattaag taaatttatt gataaatgta cttaattaac tttgaagaat ttaattcctc
      601 atgaatcaaa atataaaatt acatcaacag ttattcacaa aattaatata agaagaatta
      661 gagccaaaga gcagactatt agaccattaa agtaattatt catagaattt tgtatatgaa
      721 aagaaatgta tagtataatt tacttttttt ataaaaaata gattacaaaa tatatttttt
      781 ataaaaaggt attgacattt tttagaaaaa agaatatcat tattttaaca acaaaattca
      841 atacaataaa ttaaatccta tgacaaggaa gagtagttaa atttaggttc agtatagaga
      901 gctgaggatg gtggaatctt agcaagaaaa aatttgatga atggccctta gaggaataaa
      961 ttgaaatcat agttttgaga gtagacttta tcgtcagtcg cacgttatag cgaataaggt
     1021 atgtaagtac ctgataatga gatgtatgaa aattgaattt tatattaatt tttatataat
     1081 ttaggtggca acgcggataa tctccgtcct attagtttag gacggagttt tttattttac
     1141 tgaaaattta aaagatagaa ggtggtgaga aagatgttat gaatttcaaa agctaaagat
     1201 gatgatatag taggttggca aaaaaataaa ttgaaaatta aaaaaatagg aggaagtaca
     1261 aaaaatgaaa acaaatacaa aaaaattaac tttaaatgca atacttttag cgatgggatt
     1321 attaatacat caaatcacac cagctatagg attaccaatg aagccagatg taccactagc
     1381 aatgttattt gtaatattgg ttttaaatag agatgattat aaaacttgtt tgatagcggg
     1441 tatagtaaca ggaatattta cagcacttac atcaagtttt ccgggaggtc aaattcctaa
     1501 tgtaatagat aaaactctta cagcaaatat agtattttta ttaatgaata ttagttataa
     1561 tatgcctttt ataaaaaaat tagctaagaa aacacaagat actgtagtag ttgcaataat
     1621 aatgccaata ggaactcttg taagtggaac tatcttttta ttagcagctc aagctatagt
     1681 tggtcttcca ggggcttcat ttacagcttt attcttagca gtagtattac cagctgtttt
     1741 aataaatcta gttgcaggaa tatttttatt caagattgtt agtctatcaa taagaagagt
     1801 tagttatcaa gcttaaacac gaaataatat tttactttat aaagcattat aataactaaa
     1861 taacataaga ataaagtaga ttataactat tttattctta tgttgtttaa agatttggta
     1921 ttatatattt atttttaata aaatatttat atagtaccaa ttacacttaa tttaacagat
     1981 aaattatcat ac
//
LOCUS       DAEHWM010000200         1931 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.203, whole genome shotgun sequence.
ACCESSION   DAEHWM010000200 DAEHWM010000000
VERSION     DAEHWM010000200.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1931)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.203"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            232..1470
                     /locus_tag="KNP36_003710"
     CDS             232..1470
                     /locus_tag="KNP36_003710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conserved phage C-terminal domain-containing
                     protein"
                     /protein_id="HBF0875534.1"
                     /translation="MNKGFYKLNSVVLNFDIKNDVNKIRFNHYIMRKENIQRLQGTLP
                     NGQFYMTVRRAATDLQLSISTISRLVKEFLDLGIIRLVSKGVKGNRSVYSYVSIEFNG
                     SLFDDSKYMELDCVCNDEFIDNSGIEFDCDSKDNSFNGDINVETVHCINEYFSDDDVE
                     HNYNNFHNKDTIKDKAISNISTIKKYIDESFDTNKSENSNLQQESINFNFNDTCNEID
                     KRTNNSIENNQNKRPMRLSDISLLSDKGMTNKKNYFNHNHGIQKGTKSVTKKKESLNK
                     FNKKNIQQSIINMLNKKSGKNFKIDSPISIKLINERLKEGYVLEDFYKVIEVKVAKWK
                     NTIMEMYIRPETLFSYKFESYVNENISMKSQSNVHPCKEGNSNDSSNYIHSDYITYDG
                     SVRERKKYENVRYWNPICEI"
BASE COUNT          837 a          155 c          312 g          627 t
ORIGIN      
        1 cttgtataaa ggggaaaaat aaataaataa actatataaa taaagaaata gcaattaata
       61 tgacataata tatttataaa attaagaata taaatagata ttttaaggga ttagttgtta
      121 aattaggaaa tattaaaaaa aatatatatt tatatttaaa ctattttgtt atttatataa
      181 aaatacttat ctagttacta gcaattatta gtagaaatgg gggaaataga gatgaataag
      241 ggattttaca aattaaattc agtggtattg aactttgata ttaagaatga tgttaacaag
      301 ataagattta atcattatat aatgagaaaa gaaaacatac aaagacttca aggaactctg
      361 ccaaacggac aattttatat gacagtgaga agagctgcta cagatttaca actttctatt
      421 tctactataa gtaggcttgt aaaagagttt ttggatttag ggataataag attagtgtct
      481 aagggtgtaa aaggtaatcg ttctgtatat agttacgtaa gtatagagtt taatggaagt
      541 ttatttgatg atagtaaata tatggaactt gactgtgtat gtaatgatga atttattgat
      601 aatagtggca tagagtttga ttgtgatagc aaagataatt cttttaatgg agatataaat
      661 gtagaaactg tgcattgcat taatgagtat ttctctgatg atgatgtaga gcataattat
      721 aacaatttcc ataacaaaga tactataaag gataaagcca tttctaatat tagcactatc
      781 aaaaaatata ttgatgaatc ttttgataca aataaatcag aaaattctaa cttacaacag
      841 gagtcaataa atttcaactt taatgataca tgcaatgaaa tagataaaag aacgaataat
      901 agtatagaaa ataatcaaaa taaaaggcct atgagattga gtgacatcag tcttttaagt
      961 gataaaggta tgacaaataa aaagaattac tttaatcata atcatggtat acaaaaaggg
     1021 actaaatctg taacaaagaa aaaagaatcc ttaaataaat ttaataaaaa aaatatacag
     1081 caaagcatta taaatatgct aaataaaaaa tcaggtaaga attttaaaat cgattctcca
     1141 ataagcataa aacttatcaa tgaaaggcta aaggaaggct atgtcttaga agatttctac
     1201 aaagttattg aggtaaaagt ggctaagtgg aaaaatacca taatggaaat gtatataaga
     1261 ccagaaactt tgtttagcta taagtttgaa tcctatgtaa atgaaaacat atctatgaaa
     1321 agtcaaagta atgttcaccc atgtaaagaa ggcaatagta atgatagcag taattatata
     1381 cattctgatt atataacata tgatggcagt gtgcgtgaga gaaaaaaata tgagaatgta
     1441 agatactgga atcctatatg tgaaatttaa ttagtttaaa aatgtattta tgataaataa
     1501 gatattaata gagaatagtg agctatagca aatgatatat caatagttgg tagtaagtta
     1561 tattaagtaa gatattacta tcaggtagtg aattatattg aacgatatat taataattgg
     1621 cagtaagtta tatcaaataa gatattacta tagagtaatg aattatattg aacgatatat
     1681 taataattgg cagtaaatta tattaaataa gatattacta tagagtaatg aattatattg
     1741 gacgatatat caatagttgg tagtaagtta tattaagcaa gatattacta tcaggtagtg
     1801 aattatattg aacgatatat caataattgg tagtaaatta tattaagtaa gatattacta
     1861 tcaggtagtg aattatattg aacgatatat taataattgg cagtaaatta tattaaataa
     1921 gatattaata t
//
LOCUS       DAEHWM010000201         1925 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.204, whole genome shotgun sequence.
ACCESSION   DAEHWM010000201 DAEHWM010000000
VERSION     DAEHWM010000201.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1925)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.204"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            119..235
                     /gene="rrf"
                     /locus_tag="KNP36_003711"
     rRNA            119..235
                     /gene="rrf"
                     /locus_tag="KNP36_003711"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            242..316
                     /locus_tag="KNP36_003712"
     tRNA            242..316
                     /locus_tag="KNP36_003712"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:274..276,aa:Asn,seq:gtt)
     gene            321..395
                     /locus_tag="KNP36_003713"
     tRNA            321..395
                     /locus_tag="KNP36_003713"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:354..356,aa:Glu,seq:ttc)
     gene            401..476
                     /locus_tag="KNP36_003714"
     tRNA            401..476
                     /locus_tag="KNP36_003714"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:434..436,aa:Val,seq:tac)
     gene            482..558
                     /locus_tag="KNP36_003715"
     tRNA            482..558
                     /locus_tag="KNP36_003715"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:516..518,aa:Asp,seq:gtc)
     gene            569..643
                     /locus_tag="KNP36_003716"
     tRNA            569..643
                     /locus_tag="KNP36_003716"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:601..603,aa:Thr,seq:tgt)
     gene            658..742
                     /locus_tag="KNP36_003717"
     tRNA            658..742
                     /locus_tag="KNP36_003717"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:692..694,aa:Tyr,seq:gta)
     gene            752..825
                     /locus_tag="KNP36_003718"
     tRNA            752..825
                     /locus_tag="KNP36_003718"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:784..786,aa:Gly,seq:tcc)
     gene            836..912
                     /locus_tag="KNP36_003719"
     tRNA            836..912
                     /locus_tag="KNP36_003719"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:870..872,aa:Arg,seq:tct)
     gene            922..997
                     /locus_tag="KNP36_003720"
     tRNA            922..997
                     /locus_tag="KNP36_003720"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:955..957,aa:Gln,seq:ttg)
     gene            1009..1084
                     /locus_tag="KNP36_003721"
     tRNA            1009..1084
                     /locus_tag="KNP36_003721"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1042..1044,aa:Lys,seq:ttt)
     gene            1087..1175
                     /locus_tag="KNP36_003722"
     tRNA            1087..1175
                     /locus_tag="KNP36_003722"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1121..1123,aa:Ser,seq:tga)
     gene            1193..1283
                     /locus_tag="KNP36_003723"
     tRNA            1193..1283
                     /locus_tag="KNP36_003723"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1227..1229,aa:Ser,seq:gct)
     gene            1292..1368
                     /locus_tag="KNP36_003724"
     tRNA            1292..1368
                     /locus_tag="KNP36_003724"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1326..1328,aa:Pro,seq:tgg)
     gene            1454..1529
                     /locus_tag="KNP36_003725"
     tRNA            1454..1529
                     /locus_tag="KNP36_003725"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1487..1489,aa:Trp,seq:cca)
     gene            1590..1666
                     /locus_tag="KNP36_003726"
     tRNA            1590..1666
                     /locus_tag="KNP36_003726"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1624..1626,aa:Pro,seq:tgg)
     gene            1673..1749
                     /locus_tag="KNP36_003727"
     tRNA            1673..1749
                     /locus_tag="KNP36_003727"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1707..1709,aa:Ile,seq:gat)
     gene            1753..1828
                     /locus_tag="KNP36_003728"
     tRNA            1753..1828
                     /locus_tag="KNP36_003728"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1786..1788,aa:Phe,seq:gaa)
     gene            1836..1912
                     /locus_tag="KNP36_003729"
     tRNA            1836..1912
                     /locus_tag="KNP36_003729"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1870..1872,aa:Met,seq:cat)
BASE COUNT          484 a          442 c          524 g          475 t
ORIGIN      
        1 attcattaag atatatgtgc agtttttaga gtgttaactc taaaaaaaaa taaaaaaagt
       61 attgacaaaa atagtaaaaa atgttaatat tatacttgtc ctagcaacaa gaaaaaaatg
      121 tggttataat agcggagaag atacacctgt ttccattccg aacacagaag ttaagttctc
      181 tagcgctgat ggtacttggt gggaaactgc ctgggagagt aggacatagc cacgtgaatg
      241 ttccaaggta gctcaacggt ggagcaaccg gctgttaacc ggtaggctgt gggttcgagc
      301 cccacccttg gagccattat ggctcgttgg tcaagaggtt aagacaccgc cctttcacgg
      361 cggtaacagg ggttcaattc ccctacgagt caccatttgt gggatcatag ctcagctggg
      421 agagcacctg ccttacaagc agggggtcac aggttcgagc cctgttggtc ccaccatttg
      481 cggcctggta gttcagttgg ttagaatgcc agcctgtcac gctggaggtc gagggttcga
      541 gccccttcca ggtcgccaaa ataaaaatgc tggtgtggct caacggtaga gcagctgact
      601 tgtaatcagc aggttgtagg ttcgattcct atcaccagct ccatgtaaaa ctaatacgga
      661 ggatttcccg agcggccaaa gggggcagac tgtaaatctg ttgtcatcga cttcggtggt
      721 tcgaatccac catcctccac caattaaata tgcgggtgta gctcaatggt agagttctgg
      781 ccttccaagc cagctgtgag ggttcgatcc ccttcacccg ctccaaagaa agcgtgggtg
      841 catagctcag ctggatagag caacgccctt ctaaggcgtg tgtccggggt tcgaatccct
      901 gtgcgctcac cacatatata ttggggatta gccaagtcgg taaggcacat gactttgact
      961 catgtatgcg taggttcgag tcctgcatcc ccagccaaat aaaaatatgg tctattagct
     1021 cagtcggtag agcacctgac ttttaatcag ggtgtcccgc gttcgagtcg cggatagatc
     1081 accaatggag aggtgtccga gtggtttaag gagctggtct tgaaaaccag tgacttcgaa
     1141 aggggccgtg ggttcgaatc ccaccctctc cgccaaaaaa atgactgaat ttggagaagt
     1201 actcaagtgg ctcaagagga tcccctgcta agggattagg ctgggtaacc ggtgcgaggg
     1261 ttcgaatccc tccttctccg ccattcaaaa acgaggtgta gcgcagtttg gtagcgcaca
     1321 tggtttggga ccatggggcc gggggttcga gtcccttcac ctcgaccaac ttaagctttt
     1381 agttcagttg gttagagtgc ccaactcatg gctagtaatt ctagggtttg agtccatgaa
     1441 ggttattctt cataggggtg tagctcagtt ggtagagcgt cggtctccaa aaccgtgcgc
     1501 cgggggttcg agtccctcca cccctgccaa ataaaaagga cttgaaaaaa gttggatttt
     1561 agagtagtat aagatagtaa ataagatttc gaggtgtagc gcagtttggt agcgcacatg
     1621 gtttgggacc atggggccgg gggttcgagt cccttcacct cgaccaagaa aagggcctat
     1681 agctcaggtg gttagagcgc acgcctgata agcgtgaggt cgctggttcg agtccagcta
     1741 ggcccaccat ttgcccagat agctcagtcg gtagagcagg ggactgaaaa tccccgtgtc
     1801 ggtggttcga ttccgcctct gggcaccagg aatacggcgg tatagcttag ttggctagag
     1861 cgttcggttc atacccgaaa ggtcataggt tcgactccta ttaccgctac catctaacta
     1921 tatca
//
LOCUS       DAEHWM010000202         1911 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.205, whole genome shotgun sequence.
ACCESSION   DAEHWM010000202 DAEHWM010000000
VERSION     DAEHWM010000202.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1911)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.205"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            111..395
                     /locus_tag="KNP36_003730"
     CDS             111..395
                     /locus_tag="KNP36_003730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875535.1"
                     /translation="MLVYNKSFYPNDIFPRLDFSKIKKQLKLIDNDLSDFGSICIIEK
                     EHYTISVNSIGEINVYYDLEYENKVYRIVYEIEKLFKSQVGRFSISTYRN"
     gene            complement(1166..1381)
                     /locus_tag="KNP36_003731"
     CDS             complement(1166..1381)
                     /locus_tag="KNP36_003731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875536.1"
                     /translation="MAIVVNLDVMMAKRKISLKDLAEKIDITNANLSILKTGKAKAIR
                     FTTLNEICKALDCQPGDILEYVEDEND"
     gene            complement(1392..1859)
                     /locus_tag="KNP36_003732"
     CDS             complement(1392..1859)
                     /locus_tag="KNP36_003732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2975 domain-containing protein"
                     /protein_id="HBF0875537.1"
                     /translation="MITKFFSNILSVFLYFLLSLLGVAGIIFLCMIPMFLYDFSSDKV
                     IALIARILYFSDYFIVILFLIFIINSTKYSPFVLENVKRFKVMGFCLLINTIIECING
                     YNLNTNNIRIFGTDSGGISPLMIISFIFALMCFVIAETFDKAIKIKEDNDLTI"
BASE COUNT          772 a          203 c          237 g          699 t
ORIGIN      
        1 tttgtatttt gttttatata aagtaatttg aagaatatgg aaaaacttga ttagtacatt
       61 attaattagg gtataaaatg gtgtaaatag aatgataagg ggtggatgaa atgcttgtat
      121 ataataaaag tttttatcct aatgacatat ttccaagatt agatttttca aaaataaaaa
      181 aacagttaaa attgatagat aatgacctgt cagattttgg aagcatatgt ataatagaaa
      241 aagaacatta tacaataagt gtaaacagta taggtgaaat aaatgtgtat tatgatttag
      301 agtacgaaaa taaggtgtat agaatagttt atgagattga aaagttattt aaatctcaag
      361 ttggaaggtt tagcatatct acatacagaa attgataatt aaaaaagtag aaattaaaaa
      421 acttaatact aaagatatag ataaatatat gaggtaacag ctagagagag ttgttaccct
      481 ttttaaatac taagtatata ttattcttat taattttttg taaattcact aaaagacctt
      541 tttatagaat attattttct ttttttatta aataggtaaa tcagtaaaaa tgcaattcca
      601 gttccaatta ttattccaat gatattttct ataattaatt tttttaatat aaaagtaaat
      661 aataaaaatg ctatacataa acctaaaata tatcctttaa aataggttga aagttttctt
      721 ttcatataat caccaacttg tatcagattt agtttactta attagagtat aacagtgttg
      781 taacttcaaa gagtatctaa aagattacaa atgttagata aaatcatcaa taatgtaatt
      841 tataacacgt agctataaac tatgcaataa tataaatgga ggtataagta aatgaaaaag
      901 ttccatgttt tgctaacagt ttaaataaat attaggtaga aaagaatgta tataggaatc
      961 tgtggtaaaa ttatcaattt aaaagtatta tttagtgtga tacagttctt ataggtaatg
     1021 gataacaaat agataaagga acagtttctt tcttagaaca tattttgtta tgactttaaa
     1081 caaagttaat attaatgtca ataatatagt aaaagaataa aaatcatata gtataataaa
     1141 aaagagtgtt tctaaacact cttttttaat cattttcatc ttctacatat tcaagtatat
     1201 cacctggctg acagtctaaa gctttgcaaa tttcgtttag agtggtaaat ctaatagctt
     1261 ttgcttttcc agtttttaaa attgataaat ttgcatttgt aatatctatt ttttctgcca
     1321 aatctttaag tgatattttc ctttttgcca tcattacatc taggttaact actattgcca
     1381 taacatcacc tctatatcgt taaatcatta tcttctttta tttttatagc tttatcaaat
     1441 gtttctgcaa ttacaaagca cattagtgca aatataaaag agataatcat aagtggtgag
     1501 ataccgccac tatcagttcc aaaaattctt atattattag tatttaaatt ataaccattg
     1561 atacattcaa ttatagtgtt tatcaataaa caaaatccca ttaccttaaa cctttttaca
     1621 ttttcaagta cgaatgggga atacttagta ctattaatta taaatatcaa gaataagatg
     1681 actataaagt agtcagaaaa atatagtatt cttgcaatta aagcgattac tttgtcagaa
     1741 ctaaaatcat ataaaaacat aggtatcata cataagaata ttataccagc aactcctaaa
     1801 agtgataata gaaaatatag aaatactgat aatatattac taaaaaattt tgtaatcata
     1861 aaatatcatc tcctttatat aaagtatatt attgattata atatacaatt t
//
LOCUS       DAEHWM010000203         1903 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.206, whole genome shotgun sequence.
ACCESSION   DAEHWM010000203 DAEHWM010000000
VERSION     DAEHWM010000203.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1903)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.206"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            220..1359
                     /locus_tag="KNP36_003733"
     CDS             220..1359
                     /locus_tag="KNP36_003733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="HBF0875538.1"
                     /translation="MVIKLTIEEYKNKYFTGNKIVLSINSFDNKELYYHETENILNLI
                     NEIDKLTSSKIFKTIEDKNDLALESYYSSVIEGAFSTRKIAKSIIRGKMKPSNKSEYM
                     IYNNHRALEYGLDNLDELYSHKFIYDLHHILGENCLDSEEYEYRTEKVYVCDSKGEII
                     HTGLEPLKIYDFISKLIDFMENSKVSNLIKSAIIHFYFVYVHPFSDGNGRTSRALSYL
                     YLIDKGYDTFKDFSISYMISKNRTKYYKAILDVENKGNNLTVFIEFMLKSIIQSINEM
                     RNMHDRKSLESILKEELFENDITLSATEEHILKYICNKDNYSMTLENYIKKNKSRYLK
                     AGIKEIELVDQLMEVFNNLEEIEILSKEKNIYKVNDKYLKMLDID"
     gene            1385..1573
                     /locus_tag="KNP36_003734"
     CDS             1385..1573
                     /locus_tag="KNP36_003734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875539.1"
                     /translation="MNNKKKAFLISGAINVISLIIVFSLFHYNIIENSTQNMIITVIL
                     IFIFEMIKIKIIEKYYKL"
BASE COUNT          802 a          156 c          274 g          671 t
ORIGIN      
        1 tgtcgagata ttataatata taactaatgt attataaata atagttgtaa acttcctgta
       61 acatatattt taaatgctta ttcttaaatt tttgcattat ttattaaaat ttattatgct
      121 ttaacgctaa attgagtttg ataattataa aacaaataat caaaaatagt gtaaaaatta
      181 atactttttg ttaatattaa tagataaaga taatctaagg tggtgattaa actgacaata
      241 gaagaataca aaaacaaata ctttactgga aataaaatcg tactttctat aaatagtttt
      301 gataataaag aactatacta tcatgaaact gaaaatatat taaatttaat aaatgaaata
      361 gataaattaa catcaagtaa gatatttaaa acaatagaag ataaaaatga tttggcacta
      421 gagtcttatt attctagtgt aatagaaggt gctttttcaa ctagaaagat tgcaaaatct
      481 ataattagag gaaagatgaa accaagtaat aaaagtgaat atatgattta caataatcat
      541 agagccttag aatatggatt agataactta gatgaattgt atagtcacaa atttatatat
      601 gatttgcatc atatattggg cgaaaactgc ttggattcag aagaatatga gtatagaact
      661 gaaaaagtat atgtatgtga ttcaaaaggt gagattatac atacagggct tgaacctttg
      721 aagatatatg actttattag taaattaata gattttatgg aaaatagcaa agtaagtaat
      781 ttaattaaaa gtgctataat tcatttttac tttgtatatg ttcatccttt tagtgatggt
      841 aatggaagaa catcaagagc cttatcatat ctatatttga ttgataaagg atatgatact
      901 ttcaaggatt tttcaatatc atatatgata tctaaaaaca gaactaagta ttataaggct
      961 atacttgatg tagaaaacaa aggaaataat ttaactgtat ttatagaatt tatgctcaag
     1021 tctataatac aatctattaa tgagatgcgt aatatgcatg atagaaaatc tttagaaagt
     1081 atattaaaag aagaattgtt tgaaaatgac ataactctat cagcaacaga agaacatata
     1141 ttaaaatata tttgcaataa agataactat tctatgacat tagaaaatta tataaaaaag
     1201 aataaaagta gatacttaaa ggctggaata aaggaaattg aattagttga ccagttgatg
     1261 gaagtgttta ataatcttga agagatagag attttgtcta aagaaaaaaa tatatataaa
     1321 gttaatgata agtacttaaa aatgcttgat atagactaat ttagataatc tggagaggga
     1381 atatatgaat aataagaaaa aggcattttt gatttctggg gctataaacg taatttcatt
     1441 aattattgtt ttttcattgt ttcattataa tattatagaa aatagtacac aaaatatgat
     1501 aataactgta atcttaattt ttatttttga aatgataaaa ataaaaatca tagagaaata
     1561 ctataaacta taaacaagaa atatcttttc taagagcata ttgtacaata tgctcttaat
     1621 ttagttatat agatttaata taaataatgt attttttgta gatgatttat gtaagattta
     1681 tgaccaattt gtgtatgatt tgtgttcttt aatcatgaca atattatatt gtaaaaaata
     1741 aatttaataa aaaatgactt ggaatttata ttctaggtct tttttatata aaaatttaat
     1801 aagtttcaaa tgttggtaac tttgacagta gaaaacgtct attgagataa cgaggattct
     1861 aattgaggtg gagagatatt agcacttaaa gtagtatatg caa
//
LOCUS       DAEHWM010000204         1830 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.207, whole genome shotgun sequence.
ACCESSION   DAEHWM010000204 DAEHWM010000000
VERSION     DAEHWM010000204.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1830)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.207"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            120..1130
                     /locus_tag="KNP36_003735"
     CDS             120..1130
                     /locus_tag="KNP36_003735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4116 domain-containing protein"
                     /protein_id="HBF0875540.1"
                     /translation="MHEDKNDIFESIDTEDFDNKTEEECLELVRKNGLNLIYIKNQTE
                     EICLEAVRQNCNAIKCVQNQTEKICIEAVKQDWRMLEFVEEPTEEICMLAINQDGTAL
                     KYIENQTEELCLRAVEKNGAALEYVKEQTEEICIEAVRNSEFGLARVKNQTEKICMEA
                     VKHCSYNLKWVENQTEEICMEAVRQNGLDLKFVKNQTETICLRAVRQNGMALEFVKEQ
                     TVGICLKAVRQYGMALKFVKEQTEEICTEAIKQDKRALSFVKGDKEKYKALYDNNEPF
                     AKRYVRNVIEKENRALIKKGEENAKIKIAGKLYDRGMSFEDISDIVEIEISKLKVSLG
                     VF"
     gene            1266..1754
                     /locus_tag="KNP36_003736"
     CDS             1266..1754
                     /locus_tag="KNP36_003736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HBF0875541.1"
                     /translation="MKITVLYQTRSGNTERVAKLIEEGAKKVDGVDVKLMRLDNIDLD
                     YLNESKAVIFGTPTYLANTTWEVKKWFDEDSKKVNLAGKLGAVFATCDYICGGPDVAI
                     LTIVGHLMVKGMLVYSGGGSLGKPFIHLGHVHSIEGPELQDEKAIIFGERIATKAKEL
                     FA"
BASE COUNT          780 a          150 c          384 g          516 t
ORIGIN      
        1 acatacaaat gattttatga aaaaaaacaa gactcaaaaa tttttatatt ctttgataga
       61 ataaaattga gagtaaattt attgaatttt ataaaattta taaggggtga gtctaagata
      121 tgcatgaaga taaaaatgat atatttgaat caatagatac tgaggatttt gataataaaa
      181 cagaagaaga atgtttagag ctagtaagaa aaaatggatt gaatttaata tacataaaaa
      241 atcaaacaga agagatatgt ctagaggctg ttagacaaaa ttgtaatgca ataaaatgtg
      301 ttcagaatca gacagaaaaa atatgtatag aagcagttaa acaagattgg agaatgttag
      361 aatttgtgga agagccaaca gaagaaattt gcatgttggc tattaaccaa gatggaacag
      421 cattaaaata tatagaaaat cagacagagg agttatgctt aagagccgtt gaaaaaaatg
      481 gtgcagcttt ggagtatgta aaagaacaaa cagaagaaat atgtatagaa gcagttagaa
      541 acagcgaatt tggattggca agagtgaaaa atcaaacaga aaaaatatgt atggaagcag
      601 ttaagcattg tagctataat ctaaaatggg tagaaaatca aacagaagaa atatgtatgg
      661 aagcagtgag acaaaatggg cttgatttga aatttgtaaa aaatcaaaca gaaacaatct
      721 gtttaagagc agtaagacaa aatggaatgg cattagaatt tgtaaaggaa cagactgttg
      781 gtatatgctt aaaggcagta agacaatatg gaatggcatt aaaatttgta aaggaacaaa
      841 cagaagaaat ttgtacagaa gctataaaac aagataaaag agcacttagt tttgtaaaag
      901 gagataagga aaaatataag gctctatatg ataataatga accatttgca aagagatatg
      961 ttagaaatgt aatagaaaaa gaaaacagag cattgattaa aaaaggagaa gaaaatgcaa
     1021 aaatcaaaat tgcaggaaaa ctttatgata gaggcatgtc ttttgaagat atatcagata
     1081 tagttgagat tgaaataagc aagttaaaag tgagtttagg tgttttttaa agtaataaat
     1141 gtaggtgttt tttatgggaa atagttaata aaaaaataat cgactagctc tttgtaggac
     1201 agcaaaatta gtgatataat ttgatgtata ataaattatt tttattagat aagggggaat
     1261 taaagttgaa gattacagta ttataccaaa caagaagtgg aaacacagaa agggtcgcta
     1321 agctgataga agagggcgct aaaaaggtgg atggagtaga tgtaaagctt atgagacttg
     1381 ataatattga tttagattat ttaaatgaaa gtaaagcagt aatatttgga acacctactt
     1441 atttagcaaa tacaacttgg gaagtaaaaa aatggtttga tgaagattca aaaaaagtta
     1501 atttagctgg aaaattagga gctgtttttg ctacatgtga ttatatatgt ggaggtccag
     1561 atgttgcgat acttactata gtaggacatt tgatggttaa agggatgctt gtgtattctg
     1621 gaggtggttc tttaggaaag ccatttatac atttaggaca tgtacattca attgaaggtc
     1681 cagagttaca agatgagaag gctataatat ttggtgaaag aattgctact aaggcaaaag
     1741 aactatttgc ttaatttcta tatgcatagt aatgattaga gtaaatttag ggttttaatg
     1801 gagatttgaa gtaaaagtta taaaataaaa
//
LOCUS       DAEHWM010000205         1806 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.208, whole genome shotgun sequence.
ACCESSION   DAEHWM010000205 DAEHWM010000000
VERSION     DAEHWM010000205.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1806)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.208"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..853
                     /locus_tag="KNP36_003737"
     CDS             <1..853
                     /locus_tag="KNP36_003737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0875542.1"
                     /translation="DFKPKDMILIGIPILSNIVSLLLIFEYNLRVNTITTENLFIFIF
                     AILLILSSSIILLIVIGKIVQDDKLNLEYELINERIKTNYRNYENINEVHDRLKYVYH
                     DLKNHMICIKNYDTKEEIISYINNLEFQISEFEHFKNTGNKTLDLILAEKISICKKYD
                     IQIEDNINISKLNFIKNNDICSIFANSLDNAIEACMDINNEIEKRIEVKATYINKFAI
                     IKFINTKVNDIKLIDKRIQTSKDDDKIHGIGLASIKYIVNKYGGETIVNYSDNEFILK
                     IMIPIKS"
     gene            865..1005
                     /locus_tag="KNP36_003738"
     CDS             865..1005
                     /locus_tag="KNP36_003738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003437290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="HBF0875543.1"
                     /translation="MKKIALNLLKNISALSFGIAVLSANSASSWVAHQAKEPQALQKL
                     KK"
     gene            1064..1645
                     /locus_tag="KNP36_003739"
     CDS             1064..1645
                     /locus_tag="KNP36_003739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009891808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="accessory gene regulator B family protein"
                     /protein_id="HBF0875544.1"
                     /translation="MFKRLSYKFANILVNNEIVESEDFEIYRYGFETLIYFIVNILVA
                     LFIGIIFDRFIHTVIFLSCYCTLRQFTGGYHARNYKECTLTFAVIYLITIFSANNIDI
                     NKYKYLLVLLMIISILTIYKLAPLEHRNKPLSESEKKHYRKTVQKILFVIICLIILCK
                     ILNIFQQYVIYAIISIYWIAILIYIGMKVNSDQ"
BASE COUNT          775 a          152 c          252 g          627 t
ORIGIN      
        1 agattttaaa cctaaagata tgatactaat aggaatacct atattatcta atatagttag
       61 cttattactt atatttgaat ataatttaag agtcaataca attactacag aaaacttatt
      121 tatatttata tttgcaattt tattgatttt atcatcaagt ataatacttt taatagtaat
      181 agggaaaatt gtacaagacg ataaattaaa tctagagtat gaacttataa atgaaagaat
      241 aaaaacaaac tacaggaatt atgaaaatat aaacgaagtt catgatagat taaaatatgt
      301 ttatcatgac ttgaaaaacc atatgatttg tataaaaaat tatgacacta aagaagaaat
      361 tatatcatat ataaataact tagagtttca gataagtgaa tttgaacatt ttaaaaatac
      421 tggaaataaa acattagatt taattttagc agaaaaaata agtatttgta aaaagtatga
      481 tattcaaatt gaagataaca taaatatatc taaattaaac tttattaaaa ataatgatat
      541 atgttcaata tttgcaaatt cactagataa tgcaattgaa gcatgtatgg atataaataa
      601 tgagatagaa aaaagaatag aagttaaagc tacatatata aataaatttg caataataaa
      661 atttataaat actaaggtaa atgatattaa acttattgat aaacgtattc aaactagtaa
      721 ggatgatgat aagatacatg gaataggact tgctagtatt aaatatatag taaataaata
      781 tggtggtgaa acaatagtta attactcaga taatgagttt atattaaaaa taatgatacc
      841 aataaaaagt taggagagta caaaatgaaa aaaatagcgt taaacttact taaaaacatc
      901 tcagcattaa gttttgggat agctgtatta tcagcaaaca gtgcaagttc ttgggtagca
      961 catcaggcaa aagagccaca agctttacaa aaactaaaaa aataacatta ataaaaggac
     1021 ctcttcttat taaaggagag gttttacatg ttgaggagga aatatgttta aaagattatc
     1081 atataaattt gccaatatat tagttaataa tgagattgta gaaagtgaag attttgaaat
     1141 atatagatat ggatttgaaa ctttgattta tttcatagtt aatattttgg tagcattatt
     1201 tataggaatt atttttgata gatttataca tacagttata tttttaagtt gttattgcac
     1261 tttaagacag ttcacaggag gttatcatgc taggaattat aaagagtgta cattaacatt
     1321 tgcagttatt tatttgataa ctattttttc agctaataat atagatataa ataaatataa
     1381 gtatttatta gtattattaa tgattattag tatactaaca atttacaagt tagctccttt
     1441 agaacataga aacaaacctc ttagtgaaag tgagaaaaag cattatagaa agactgtgca
     1501 aaaaatacta ttcgtaataa tatgtttaat tattttatgt aaaatactta atatttttca
     1561 gcaatatgtg atttatgcaa taatttctat atattggatt gctatattaa tatatattgg
     1621 aatgaaggtt aatagtgatc agtaagatta taaaacattt tctaaattaa ttaacttcac
     1681 taattaatat taactttaaa aaaataatgt caaggtaagt atttgaactt attaaatata
     1741 gttgaatcta ttgtaggttg tatcaaaaga ctggctagga ggggcataaa tatgagtagt
     1801 attaag
//
LOCUS       DAEHWM010000206         1786 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.209, whole genome shotgun sequence.
ACCESSION   DAEHWM010000206 DAEHWM010000000
VERSION     DAEHWM010000206.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1786)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.209"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            147..1745
                     /locus_tag="KNP36_003740"
     CDS             147..1745
                     /locus_tag="KNP36_003740"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative manganese-dependent inorganic
                     diphosphatase"
                     /protein_id="HBF0875545.1"
                     /translation="MSLLVFGHKNPDTDSICSAISLAHLKNKLGIKATAYALGDIRKE
                     AKYALDYFKVDAPEILDNVRIQVRDLNYDKVVPLTPTSSILEAYNLMDEKNVKTLPVT
                     YDDGTFAGIITMKEIAKNLLHQHFTTIHTSLSNICKNLNGTILVDCGEDIKGRVVTLS
                     FGMETLIETLKEGDIAIVGDRYDSIEYAIDTKVKLLILTNHTEISKDLLALAKINGVS
                     VVSVESDNYKTSNVINQCSFLDSIEATENLITFKEDDYMDEIKEIMLETNFRSYPILD
                     DDNKFLGLVSKGHLLNPSKKNVVLVDHNEYAQSADGIEQANIVEIIDHHKLGGISTDV
                     PMSFRVMPVGCNSTIIYQMYKENNVEIPYEIAGLLLSAILSDTLLFKSPTTTDIDKKA
                     CEELSKIAKVDMEKYAMDMFKCGTSLDEYTIEEIVNMDFKEFNMSGHRVGIGQVFTLD
                     IDSIFAKKDEFLSYINSTDYDKLILAVTDIIKEGSYLIYKAEDSLIANAFGVEGVQGT
                     FAPGVVSRKKQLVPNLTTAIKNFK"
BASE COUNT          685 a          220 c          275 g          606 t
ORIGIN      
        1 taaatttgta gtatttatgt aagaaataaa ttttatataa tattttttca ctaaattttt
       61 ttctttttac aacaaatact cactaccttt tgatataata tttttatcaa ttattattat
      121 attcaagttt tgaaaggagt attaaaatga gtttattagt tttcggacat aaaaatccag
      181 atacagattc aatatgttct gcaatttcat tagcacattt aaagaacaaa ctaggaataa
      241 aagcaacagc ttatgcttta ggagatatca gaaaagaagc taaatatgcc ttggattact
      301 ttaaggtaga tgcacctgaa attttagata atgttagaat acaagttaga gatttaaatt
      361 atgataaagt agtaccttta acaccaactt catctatatt agaggcttat aaccttatgg
      421 atgaaaaaaa tgttaaaaca ctacctgtaa cttatgatga tggaactttt gctggtatca
      481 ttactatgaa agaaatagct aaaaatctac ttcatcaaca ctttacaact atacacacat
      541 cactatcaaa catttgtaaa aaccttaatg gtactattct tgtggactgt ggtgaagata
      601 taaaaggtag agtagtcact ttatcatttg gaatggagac tctaatagag actttaaaag
      661 aaggagacat agctattgtt ggagatagat atgatagtat tgaatatgct attgatacaa
      721 aagttaaact tttaatactt actaatcata cagagatttc aaaagatttg ctagctcttg
      781 ctaagataaa tggagtgtct gttgtttctg ttgaaagtga caattataaa acttctaatg
      841 taataaatca atgtagtttc ttagactcta tagaagctac agaaaattta attacattca
      901 aagaagatga ttatatggat gaaataaaag agattatgct agaaacaaac ttcagatctt
      961 atccaatatt agatgatgat aataagtttt taggtttagt ttcaaaaggt catctattaa
     1021 acccatctaa aaagaatgtt gttttagttg accataacga atatgctcaa agtgctgatg
     1081 gaattgaaca agcaaacata gttgaaataa ttgaccatca taaacttggt ggtatttcta
     1141 ctgatgttcc tatgtcattt agagttatgc ctgttggatg caatagtact ataatttatc
     1201 aaatgtacaa agaaaataat gttgagatac cttatgaaat agccgggctt cttttatctg
     1261 ctatattatc agatacatta ttatttaagt ctccaacaac aactgatata gataagaaag
     1321 cttgtgaaga attaagtaaa atagcaaaag tagacatgga aaaatacgct atggatatgt
     1381 ttaaatgcgg tacttcttta gatgaatata ctatagaaga aatagtaaat atggacttta
     1441 aagaatttaa tatgagtgga catagagttg gtattggaca agtatttacc ttagacatag
     1501 actctatatt tgctaaaaaa gatgagtttt tatcttatat aaattcgact gattatgaca
     1561 aactaattct tgcggttaca gatataatca aagaaggttc ttatttaatc tataaagcag
     1621 aagacagctt aattgctaac gcatttggtg ttgaaggtgt tcaaggtaca tttgcaccag
     1681 gtgttgtatc aagaaaaaaa caattagtcc ctaatttaac tactgcaatc aaaaatttta
     1741 aataatataa aatttttaaa taacgaaaac tgtctcaaat ctatat
//
LOCUS       DAEHWM010000207         1786 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.210, whole genome shotgun sequence.
ACCESSION   DAEHWM010000207 DAEHWM010000000
VERSION     DAEHWM010000207.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1786)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.210"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(497..886)
                     /locus_tag="KNP36_003741"
     CDS             complement(497..886)
                     /locus_tag="KNP36_003741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="HBF0875546.1"
                     /translation="MTIKKLPQSELKIMKFIWKSDSKVTSRDIVLGMEQKYQWKQTTT
                     LTLLSRLVVKRFLNSQKIDKYTHYEVLIKEKEYIGVETRDFFRNIHDSSIKSLLLSLH
                     ENINLSKDDILLIEEWIKNLKEEEKDV"
BASE COUNT          580 a          324 c           96 g          786 t
ORIGIN      
        1 ttttcaatat cttctattaa tacttttgtt tctacctctt cagtatctta tatcaatctt
       61 ttattttttc aatatcttct gttaacactt ttatctctat ctctttaata tcttatatta
      121 atcctttatt tttatttttt caatatcatc attaattcct atttatttta tcatcttaaa
      181 tacgaaaaca ctgtgtcata tttgcaaaat atatattatc atctatatta aagcttcaca
      241 atttatattt aaaaattctc tttaattaca ctacctctat ttaaaaagct accttaatta
      301 tacttataag taaaggtagc tttttaaatt taattaaata gaatatccac tattaattta
      361 tatttaattt atttagattc acattatagt atcataatcc acttataatc atttgtcata
      421 ttacttaagt agactaatat attacataaa tacacttaca tacactttat attgatgcta
      481 taagaaatac gtttgcttat acgtctttct cctcttcttt tagatttttt atccactctt
      541 caataagtaa aatatcatct ttgctcaaat taatattttc atgtaatgac aacaataaac
      601 tttttataga agaatcatga atatttctaa aaaaatctct tgtctcaact cctatgtatt
      661 ccttttcttt aattaaaact tcataatgcg tatatttatc tatcttttga gaatttagaa
      721 atctttttac tactaatcta gataaaagag tcaaagttgt cgtttgtttc cattgatatt
      781 tttgctccat tcctaaaaca atatctctag atgttacttt ggaatctgat ttccatataa
      841 atttcattat ctttaattct gattgtggca acttttttat agtcatgata aaaccttgct
      901 actcagaata tagacaagca atatccataa taaaattttt cgattaaata catcttatac
      961 ggatttatat aagctcagac ttataagata tttttcaatc ttaatcctaa atttagctat
     1021 ttgtacacgg taaatatata taaataatgt caaaattctc ttgtattata ttgcttaatt
     1081 ttatgaaata ttttgtactc agctatctat tttggatact tgtccagtag ctctcctttc
     1141 ttttaaactc tttgatttta aatatttgta tttcagtaaa tcctacttcc taaatttttt
     1201 atttactaca acttattact gaacttccta cttcctaaac tttttattta ctacaactta
     1261 ttactgaact tctcacttac taaatttctt acttactata aattataact aaacttctca
     1321 cttactaaat ttcttactta ctataaatta ctactaaact tcctactttc taaatttctt
     1381 acttgctaca aattattact aaacttcctc tccctaaatt tcttacttgc tataaattat
     1441 tactaaactt cctactttct aaatttctta cttactataa attattacta aacttcctac
     1501 tccctaattt tcttacttac tataaattat tactaaattt cctactttct aaatttctta
     1561 cttactacaa attattacta aacttcctac tccctaaatt tcttacttgc tataaattat
     1621 tactaaactt cctactccct aagtttctta cttgctacaa attattacta aacttcctac
     1681 ttcctaaatt tcttacttgc tataaattat tactactaaa cttcccactt cctaaatttc
     1741 ttacttacta ctacttataa ctaaacttcc cacttcctaa atttct
//
LOCUS       DAEHWM010000208         1717 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.211, whole genome shotgun sequence.
ACCESSION   DAEHWM010000208 DAEHWM010000000
VERSION     DAEHWM010000208.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1717)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1717)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1717
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.211"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            88..1578
                     /locus_tag="KNP36_003742"
     CDS             88..1578
                     /locus_tag="KNP36_003742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="HBF0875547.1"
                     /translation="MFQFETQIHKLRHDVLTAIARLGKEDNLTREAMDNIQYEIIKGE
                     KPTYRCCVYKERAIISERVNVSMGLQPGQDKIDLDTMDIEEDEQIIYILEAACDSCPI
                     NEFTVTDICRGCLAHRCKEACKFGAITHVGGMAYINHELCKACGMCKKACQYDAISEV
                     VRPCKSVCPTNALGFDRENMKAMIHEDKCLNCGACMSACPFGAISDKSLIAPVARKLV
                     QKEKMYAVVAPAITGQVEANVTYGQIKNAIKSLGFVDVLEAACGADAVTVHESLEFAE
                     RMEKGEAFMTNSCCPGFVGYIEKTYPNHVGKISSTVSPMIASGRFIKSHEPDAKVVFI
                     GPCTAKKSEAAKKELKGAVDYVLTFEEIMALFEAFDIDLAKCSNEDIDDASIFGRGFG
                     AAGGLTKAIENYLAEKGIGVNFEPVKISGSREIKKTMTMANLGKLEGNFIEGMMCEGG
                     CINGSGKFLSGAKVKATFDRKNSQSTKKSVLANTKIKDFSNINLEK"
BASE COUNT          659 a          183 c          350 g          525 t
ORIGIN      
        1 catataatat tttatgtata tattaataaa aggacatatt gtgttataat ggtatcgtat
       61 aaaatcattt acgggggtgg tattaaaatg tttcaatttg aaacacaaat acacaaatta
      121 agacatgatg ttttaactgc aatagctaga cttggaaaag aagataacct taccagagaa
      181 gcaatggata atattcagta tgaaataata aaaggtgaga aacctacata cagatgttgt
      241 gtttataaag aaagagctat aatatctgag agagtaaatg taagtatggg gttacaacca
      301 ggtcaagata agatagattt agatacaatg gatatagaag aagatgaaca aattatatat
      361 attttggaag ctgcatgtga cagttgtcca ataaatgaat ttacagtaac agatatttgt
      421 agaggatgtc tagcacatag atgtaaagaa gcttgtaaat ttggagctat aacacatgtc
      481 ggaggaatgg cctatataaa tcatgaatta tgtaaggctt gtggaatgtg taaaaaagct
      541 tgtcaatatg atgccatctc agaggttgtt agaccatgta agagtgtttg tccaactaat
      601 gccttaggat ttgatagaga aaatatgaaa gctatgatac atgaggataa atgtttaaac
      661 tgtggagcat gtatgtcagc atgtccattt ggagcaatat ctgataagag tttgatagct
      721 cctgtagcta gaaagttagt tcaaaaagag aaaatgtatg cggtggtagc tccagctata
      781 acaggtcaag ttgaagcaaa tgttacatat ggtcaaataa aaaatgctat aaaatcacta
      841 ggatttgttg atgtattaga agcagcttgt ggagcagatg cagttacagt tcatgaaagc
      901 ttagaatttg ctgaaagaat ggaaaaggga gaagctttta tgacaaattc ttgttgtcca
      961 ggatttgttg gttatataga aaaaacatac ccaaatcatg tagggaaaat atcttctaca
     1021 gtatctccta tgatagctag tggtagattt ataaaaagtc atgaaccaga tgctaaagtt
     1081 gtattcatag gaccatgtac agccaaaaag agtgaggcag ctaagaaaga attaaaagga
     1141 gctgttgatt atgtacttac ttttgaagaa ataatggcat tatttgaggc atttgatata
     1201 gacttggcta agtgttcaaa tgaagatata gatgatgcat caatttttgg aagaggtttt
     1261 ggagctgctg gtggtcttac aaaagctata gaaaattatc ttgctgaaaa aggtattggt
     1321 gttaattttg aacctgtaaa gatttctggt tcaagagaaa tcaagaaaac tatgactatg
     1381 gctaatttag gaaagctaga aggtaatttt atagaaggaa tgatgtgtga aggtggttgt
     1441 ataaatggtt ctggtaaatt cttatcaggt gcaaaggtta aagccacttt tgatagaaaa
     1501 aattctcaat caactaagaa aagtgtctta gcaaatacaa agataaaaga ttttagtaat
     1561 ataaatttag aaaaataaag ataatacaaa gcaacaaaaa tacatattgt taatagagtt
     1621 gttctaagtt gaggtttaac ttttggacaa ctctattttt atttatatat ttaattattg
     1681 aacaactaaa ataaaaatta tatacactta aaataaa
//
LOCUS       DAEHWM010000209         1592 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.212, whole genome shotgun sequence.
ACCESSION   DAEHWM010000209 DAEHWM010000000
VERSION     DAEHWM010000209.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1592)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.212"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            39..155
                     /gene="rrf"
                     /locus_tag="KNP36_003743"
     rRNA            39..155
                     /gene="rrf"
                     /locus_tag="KNP36_003743"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            163..237
                     /locus_tag="KNP36_003744"
     tRNA            163..237
                     /locus_tag="KNP36_003744"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:195..197,aa:Asn,seq:gtt)
     gene            243..328
                     /locus_tag="KNP36_003745"
     tRNA            243..328
                     /locus_tag="KNP36_003745"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:277..279,aa:Leu,seq:taa)
     gene            344..419
                     /locus_tag="KNP36_003746"
     tRNA            344..419
                     /locus_tag="KNP36_003746"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:377..379,aa:Met,seq:cat)
     gene            427..501
                     /locus_tag="KNP36_003747"
     tRNA            427..501
                     /locus_tag="KNP36_003747"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:460..462,aa:Glu,seq:ttc)
     gene            516..589
                     /locus_tag="KNP36_003748"
     tRNA            516..589
                     /locus_tag="KNP36_003748"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:548..550,aa:Gly,seq:tcc)
     gene            595..670
                     /locus_tag="KNP36_003749"
     tRNA            595..670
                     /locus_tag="KNP36_003749"
                     /product="tRNA-Val"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:628..630,aa:Val,seq:tac)
     gene            676..752
                     /locus_tag="KNP36_003750"
     tRNA            676..752
                     /locus_tag="KNP36_003750"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:710..712,aa:Asp,seq:gtc)
     gene            763..837
                     /locus_tag="KNP36_003751"
     tRNA            763..837
                     /locus_tag="KNP36_003751"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:795..797,aa:Gly,seq:gcc)
     gene            847..920
                     /locus_tag="KNP36_003752"
     tRNA            847..920
                     /locus_tag="KNP36_003752"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:881..883,aa:Arg,seq:tct)
BASE COUNT          505 a          273 c          335 g          479 t
ORIGIN      
        1 tattaaaaac ttaatagaaa tattaagcat aaagattatg tggttacaat agcagagagg
       61 atacacctgt tcccattccg aacacagaag ttaagctctc tagcgctgat ggtacttggt
      121 gggaaactgc ctgggagagt aggacgtagc cacgttaaat gttccaaggt agctcaacgg
      181 tggagcaacc ggctgttaac cggtaggctg tgggttcgag ccccaccctt ggagccaaaa
      241 aagccgaagt ggcggaactg gcagacgcac aggacttaaa atcctgcggg acttacctct
      301 cgtaccggtt cgattccggt cttcggcact tataaaacaa tatcgcgggg tggagcagtt
      361 ggcagctcgt cgggctcata acccgaaggt cgtaggttca agtcctgcct ccgcaaccat
      421 taaaacggct cgttggtcaa gaggttaaga caccgccctt tcacggcggt aacaggggtt
      481 caattcccct acgagtcacc aattcaatta aatatgcggg tgtagctcaa tggtagagtt
      541 ctggccttcc aagccagctg tgagggttcg atccccttca cccgctccaa aaatgggacc
      601 atagctcagc tgggagagca cctgccttac aagcaggggg tcacaggttc gagccctgtt
      661 ggtcccacca ttcgcggcct ggtagttcag ttggttagaa tgccagcctg tcacgctgga
      721 ggtcgagggt tcgagcccct tccaggtcgc caaattaaat aagcgggaat agttcagtgg
      781 tagagcgcaa ccttgccaag gttgaagtcg cgagttcgaa tctcgtttcc cgctccataa
      841 taacttgggt gcatagctca gctggataga gcaacgccct tctaaggcgt gtgtccgggg
      901 ttcgaatccc tgtgcgctca ttaagaaaag tttactataa attatagtaa acttttatat
      961 tgtttaaaaa gacacaggaa acatgtatat tacctgtgtc tttttattta taaactttaa
     1021 actatgtaaa aattacagta tattctaata gagttacagt atattcatta atattgtaaa
     1081 catacggagg gtaatgtata atagtctaca agatgtttat gaaggcatca gttaaatata
     1141 ataaatataa ctaattagta agagttatat acattatatt gtatacttta tggtatttat
     1201 atattgaaat aacttatgaa attatttata aagagattca tgagcatatt tttgtctaaa
     1261 caataagtat aagaaattat aaaaaattag agactatagt gaatttacaa tttaatgtaa
     1321 tatttataag ttatactaaa taaattatta tactgtgaaa tggatatata actttaggta
     1381 ttgtgtatta ttttcactgt aggagattat atctagttat acataataag ttttaatgat
     1441 agtttatagt aagatattaa aataaattta tctaatctag atatgaaata agttattact
     1501 ttaatataaa aatgaatcta atggaataat attgatgata agtaatattt agattttgta
     1561 tttgtttata gttaataagt ggattataga at
//
LOCUS       DAEHWM010000210         1582 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.213, whole genome shotgun sequence.
ACCESSION   DAEHWM010000210 DAEHWM010000000
VERSION     DAEHWM010000210.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1582)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.213"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            109..1449
                     /locus_tag="KNP36_003753"
     CDS             109..1449
                     /locus_tag="KNP36_003753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GHKL domain-containing protein"
                     /protein_id="HBF0875548.1"
                     /translation="MIKSSLFWNIFIAISFMIEWFLCKKMLDYTSEKRISNKKINFCM
                     VGIIVFADIIYFFDVPPNIRVIISMIITIAFYKISYDVGFIKSVLISLIYWMLLIATD
                     ALSISLTVWLNSINDMSSMGTGDIYRIESIILGKILLIVSLLLYRALKIKLNIEINKR
                     TLFYIVIPIVANIASFFVIFEYIFNPGSGSLIHNFQFVMISVVLLISSITLVLIAKKL
                     QQYNTLVVENNMIKNTLKYENEYYEDIEKKYLKTRLLSHDMKNHILCINAMIKKGIDV
                     TSYLNNLQVEIQSNDLLFNTGNFILDAILSEKKEVCDKNDIELKIGINFSCCEAVELV
                     DICHIFSNILDNAIEACNKIDSGNRVICVKGDVMQNFYLIRVENTKINKIITKNGDIL
                     TDKKGSLHGLGIKSVKNSVNKYGGNVVIEYDDKKFVVKIAIPLRNVKKAVNHVI"
BASE COUNT          615 a          120 c          258 g          589 t
ORIGIN      
        1 tttggaataa ttttgacaat ctatttacta catgtgtaga gtcgtatata attaaattat
       61 acataaaata taaaaaaata atttagtaat acgttaggag aaagtattat gataaagtca
      121 agcttatttt ggaatatttt cattgcgata tcctttatga tagaatggtt tctttgtaag
      181 aaaatgctag attatacaag tgagaaaagg atttctaaca aaaaaataaa cttttgtatg
      241 gtaggtatta ttgtttttgc tgacataata tatttttttg atgtacctcc aaatataaga
      301 gtaattatat ctatgataat tactattgca ttttataaaa tctcatatga tgtggggttt
      361 ataaagtctg tattaatatc cttaatttat tggatgttac taatcgccac agatgctttg
      421 agtatatctt taacagtttg gcttaattct ataaatgaca tgagtagtat ggggacggga
      481 gatatataca gaattgagtc tataatattg ggaaagatac ttttgattgt gtctttgctt
      541 ttatatagag ccttaaagat aaaacttaat atagaaataa ataaaaggac attattttat
      601 atagttattc ctatagtcgc taatatagca tctttttttg taatttttga atacatattt
      661 aatccagggt ctggtagctt aatacataat ttccaattcg ttatgatttc tgttgtattg
      721 cttatatcaa gtatcacttt agttttaatt gctaaaaaat tacagcaata taatacttta
      781 gttgtagaaa acaatatgat taaaaatact ttgaagtatg aaaatgagta ttatgaagat
      841 atagaaaaga aatatttaaa aactagatta ctaagtcatg atatgaaaaa tcacatattg
      901 tgtataaatg ctatgattaa aaaaggtatt gatgttactt cttatttaaa taatttgcag
      961 gtagaaattc agagtaatga cttgttattt aatactggta attttatatt agatgctata
     1021 ttaagtgaaa agaaagaggt ttgtgataag aatgatatag aactaaaaat aggaataaat
     1081 tttagttgtt gtgaagctgt tgaattagtg gatatatgtc atatattttc aaatatttta
     1141 gacaatgcaa ttgaggcatg taataaaatt gatagtggaa atagagttat ttgtgttaaa
     1201 ggtgatgtta tgcaaaattt ttatttaata agagttgaaa atactaagat aaataagatt
     1261 attactaaaa atggagatat tttgacagac aaaaaaggtt ctcttcatgg acttggaata
     1321 aaaagtgtaa aaaactctgt aaataagtat ggtggtaatg ttgtaattga atatgatgat
     1381 aaaaaatttg tagttaaaat tgctattcca cttagaaatg tgaagaaagc agttaatcat
     1441 gtgatttaaa tgtatataaa tttgatgtgt agaaatttaa tatataagaa ttaatgtata
     1501 aaagtgatgc atagaagttt aatatataag aattaatgta taaaagtgat gcatagaagt
     1561 ttaatatata agaactaatg ta
//
LOCUS       DAEHWM010000211         1580 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.214, whole genome shotgun sequence.
ACCESSION   DAEHWM010000211 DAEHWM010000000
VERSION     DAEHWM010000211.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1580)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.214"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(387..1094)
                     /locus_tag="KNP36_003754"
     CDS             complement(387..1094)
                     /locus_tag="KNP36_003754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HBF0875549.1"
                     /translation="MIFTKSNKYDKDFLMKNMMGPNCIKILEELTSKIKLEKGMRILD
                     LGCGKGISSIFLAKEFDATVFATDLWIEPTENYKRFKEFKLDDKIFPIQAEAHELPYA
                     EGFFDAVISIDSYHYFGNKEGFLDNHISPLVKEGGILAMAMPGLKEDFVDCIPDELIP
                     FWQDNMNFHSITWWNKLWSESESVIVEKCEALNCHDEAWKDWINCDNSYAINDKKMME
                     VENGKYFNTISLIARTK"
BASE COUNT          511 a          273 c          136 g          660 t
ORIGIN      
        1 aatttgattt aaagtataat aaaatatata aaaaaatata taaaatggta ctataaaatt
       61 tttaatcttc atcaatacct tttttgcttt cattgttaaa actatttttt ctattagttt
      121 atttcttata aaacaaacat ttagtattaa aatatatatc acacaatagt atttgcaatt
      181 taactttaaa aaaataaaaa tacccaactg acctaagcaa ctcgattggg tataaataat
      241 ctaaaaaatc atttttgtat aaactcttta tttaacttac atttttattt accttctact
      301 ttaattcaac ttatatttct atgcttctta tactctcatt caacttatat ttctacttat
      361 cttatacttt tataaattca tcacaattat ttagttctcg ctatcaaaga aattgtatta
      421 aaatactttc cattctctac ttccatcatt tttttgtcat ttatagcata tgaattatca
      481 caatttatcc aatccttcca agcttcatca tgacaattta aagcttcaca tttctctaca
      541 atcacagact ccgattcaga ccaaagttta ttccaccatg taattgaatg gaagttcata
      601 ttatcttgcc aaaatggaat gagttcatct ggtatacaat ccacgaaatc ttcttttaat
      661 ccaggcattg ccatagcaag tattcccccc tcttttacaa gaggtgatat atgattgtct
      721 aaaaatcctt ctttgtttcc aaaatagtga taagaatcga tacttatcac cgcatcaaag
      781 aaaccttctg cataaggtag ttcatgtgcc tctgcctgta ttggaaatat tttatcatcc
      841 aatttaaact ctttaaatct tttatagttt tcagttggtt ctatccataa atctgttgca
      901 aatacagtag catcaaattc ctttgctaaa aatatcgaag atataccctt accacaacct
      961 aagtctaaaa tacgcattcc cttttctagt tttatcttac ttgttaattc ttccaatatt
     1021 tttatacaat taggtcccat catatttttc atgagaaagt ccttatcgta tttattactt
     1081 tttgtaaata tcattctatc tttcctttcc ctatcagtta ttatttatta aattttatac
     1141 gtttgatttt ttatttttta tctgcttctt atattgagca atctcttttt tattcattct
     1201 ttaacagaca attttaatgt gtaattttat ccactctgtg atagtaactt taatgaataa
     1261 tcttatctac tgtgatagtt attttagtga gtaattttat ctactccaca gcaatcgctt
     1321 taatgagtaa tcttatccac tctatgatag ttattttagt gagtaatttt atctactcca
     1381 cagtaatcgc tttaacgagt aatcttatct actctataat agtcacttta atgagtaatc
     1441 ataattttta tatcatttta gatacttact ctaataagaa ttcattttct aatacttaat
     1501 aagttttaat tacttccact ttaacctata tactaattaa cttatttaat ttagtgcata
     1561 tttgacactt taccttttat
//
LOCUS       DAEHWM010000212         1467 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.215, whole genome shotgun sequence.
ACCESSION   DAEHWM010000212 DAEHWM010000000
VERSION     DAEHWM010000212.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1467)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.215"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(174..665)
                     /locus_tag="KNP36_003755"
     CDS             complement(174..665)
                     /locus_tag="KNP36_003755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfbM family protein"
                     /protein_id="HBF0875550.1"
                     /translation="MGMIGCYTKISEENVFKLQQAEENLQDFVFEDANENSTINIDKA
                     WHAIHFTLTGCPFGGDDDNIFSKLVLSGNILMEIDGEFPVMLITANDVKKLSKAMNSL
                     EEQAFRKRFNINEMLENNIYPVMNDESEDDFFEYVWANLIELKKFIQEASDDGLAVIF
                     FIM"
BASE COUNT          538 a          200 c          120 g          609 t
ORIGIN      
        1 tatatatgct aatataaata tttataaaga cataagacaa atttacctac agatttaaat
       61 ttaacttata tattttaaaa ggctaatata atatgtattt tcttctatac aatcaaaagg
      121 cttcatatct aagatatgtg atgacactaa tattcacaat tttttagtaa ttatcacatt
      181 ataaaaaata ttacagctag tccatcatca gatgcttctt gtataaactt tttaagctca
      241 attagatttg cccatacata ttcaaaaaaa tcatcttcac tctcatcatt cataacagga
      301 taaatattat tttctaacat ctcattaata ttaaatcttt ttctaaatgc ttgttcttcc
      361 aaactgttca ttgcttttga tagttttttt acatcatttg ctgtaatcaa catgacagga
      421 aattctccat caatttccat aagtatgttt ccacttagta ctaatttgct aaatatatta
      481 tcatcatctc caccaaaagg acaacctgtc aaagtaaagt gaatggcatg ccatgcttta
      541 tcaatattga tagtactatt ttcgttggca tcttcaaaaa caaaatcttg taagttttct
      601 tctgcttgct gtaatttaaa aacattctct tcacttattt tagtataaca tcctatcatc
      661 cccataatta cattcctcct aagtagcgtt tttttaattg taacttataa ttaaacttag
      721 ttacaataaa atatattgag aaaagtatta tttcatctta aatttaaata cctatattat
      781 caactaaaat tctgtgttta tagcgtaagt attattattt tttcctaaaa attaaatgaa
      841 tcagaagttc tataggcaat attgactata aataagaact attactttta aaaaaaaatt
      901 taagaaatta tactgtagaa tcatgctcta cttattagct ttaaataaaa aataaatcat
      961 gttctcaaat taaataataa ataacaataa atttaaattt taaactataa gagtttctga
     1021 agtgttaata agcataccaa taattatatg tgtaagaatt tgatttaata gatatgaata
     1081 atttttacat taattataaa tatattaacc tattgttata aattctaaaa aagaaaagtt
     1141 atcttaaata aaaaataagt gtatcttaaa ttttaaatga tacacttatt tttatattga
     1201 aattatattt tttaatatct attcttaatt aggtattttt aaattatctg tttacattaa
     1261 atatttctta attacttatc tttcagctag ctttttctat taaatgtttc tcaattactt
     1321 atttttcaat tagccactta tattaagcat ttcttaatta cttatttttc aattagccac
     1381 ttatattaaa catttcttaa ttatttattt ttcagttggc tttttctatt aaatgtttct
     1441 taattactta tctttcagtt agctctt
//
LOCUS       DAEHWM010000213         1448 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.216, whole genome shotgun sequence.
ACCESSION   DAEHWM010000213 DAEHWM010000000
VERSION     DAEHWM010000213.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1448)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.216"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            13..1293
                     /locus_tag="KNP36_003756"
     CDS             13..1293
                     /locus_tag="KNP36_003756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009896097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HBF0875551.1"
                     /translation="MNILGLIVEYNPFHNGHIYHLSKSIEKTNATHTVAIMSGNFLQR
                     GEPALFDKYTRAKIAVENGVDLVIELPTLFACQSAEIFSHGAITILNSLNCINSICFG
                     SEEGNTEILYNLAEILANEPNEFKLLLKKYLDDGLLFPTARANALFDYIHQDKKNNFI
                     QNYSKEQLSKTLNSSNNILGIEYIKNLIHLNSSIKPFTISRVQSEYNSEEIESDICSA
                     TAIRTSLKENTDLFHLKNVIPEKTYNILNEKIDNGFLPMFDDFFFDILKTIILRDMDT
                     LKEYFEVNEGIENRIYKDIFTSEFLHELQLAIKSKRYTLTKIKRTLNNILLGIKKSDV
                     QLIKNIDTIPYIRILAFNDKGREILKEIKNKSEIKIINKFSNISFSLDDTIFKTLISY
                     DIKATNIYNSIYYKNNKDLVKGPMDFYTHPIYVK"
BASE COUNT          607 a          190 c          168 g          483 t
ORIGIN      
        1 aaggagtatt ttatgaacat acttggatta atagttgaat ataacccatt tcataatgga
       61 cacatatatc atttatctaa atctatagaa aaaacaaatg caacacatac tgtagcaata
      121 atgagtggaa attttctaca aagaggcgaa ccagctttat ttgataaata cactagagca
      181 aaaattgctg tcgaaaatgg tgtagactta gttatagaat taccaacttt atttgcttgt
      241 caaagtgctg aaattttttc tcatggtgct ataacaattt taaattcact aaactgcata
      301 aattctatat gttttggtag tgaagaagga aatacagaaa ttctttataa tctagctgaa
      361 attttagcaa atgaaccaaa tgaatttaag ttacttttaa aaaaatattt agatgatggt
      421 ctgttatttc caacagctag agctaatgca ctttttgatt atatacatca agacaaaaaa
      481 aataatttta tacaaaatta ttcaaaggaa caattatcaa aaacattaaa ttcatcaaac
      541 aacatactgg gtatagaata cataaaaaac ctcatccatt taaacagtag tataaaacca
      601 tttactatct ccagggtcca atcagaatat aattccgaag aaattgagag tgatatttgt
      661 tctgctactg ctataagaac ttcacttaaa gaaaatacag acctttttca tttaaaaaat
      721 gttattccag aaaaaactta taacatccta aatgaaaaaa tagataatgg ttttttacct
      781 atgtttgatg acttcttctt tgatatttta aaaacaatta tacttagaga tatggacact
      841 ttaaaagagt attttgaagt aaatgaaggc atagaaaaca gaatctataa agatatcttt
      901 acatctgaat ttctacatga actacaatta gcaattaaat ccaagcgata cactttaacc
      961 aaaatcaaac gaactctaaa caatatattg ttaggtatta aaaaaagcga cgtgcaactt
     1021 ataaaaaaca tagatactat accttatata agaatacttg cttttaatga taaaggtaga
     1081 gaaattctaa aagagataaa aaataaatct gaaataaaaa taataaacaa gttttcaaat
     1141 atatcatttt cattagatga tacgattttt aaaacactca taagttatga tataaaagct
     1201 acaaatatat ataattcaat atattataaa aacaataaag atttagtaaa aggccctatg
     1261 gatttttata ctcatccaat atatgtaaag tagtttttta aaataactat atttataaaa
     1321 atcattttat taactcttta ttatataaga tacaatagtc ttactttatt tatgtacaca
     1381 tgcttttagg atgacaacat caacttaaat attatgttac tttctaaatt taagtaaata
     1441 ttgccatc
//
LOCUS       DAEHWM010000214         1417 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.217, whole genome shotgun sequence.
ACCESSION   DAEHWM010000214 DAEHWM010000000
VERSION     DAEHWM010000214.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1417)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.217"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            214..909
                     /gene="cas6"
                     /locus_tag="KNP36_003757"
     CDS             214..909
                     /gene="cas6"
                     /locus_tag="KNP36_003757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated endoribonuclease Cas6"
                     /protein_id="HBF0875552.1"
                     /translation="MIKCLEMSVKVYLLENISLDNTSKEIRKLIDDTLIIEEKYKEFH
                     NKAGFKNYSFNLLYPLEKDKVYKKDCIYTFIIRTVDSELGMYFMNNLKNQHSDKIKVI
                     TMSKKVIPKKHIESIYSVTPIIAKFEDGYWRSNKTVEDLEKRIRENLIKKYNEFTNSK
                     IDEDFELFQVIKFINRKPISTKYKNISLLGDKISFKVSENDMAQEIANFALGVGVGEI
                     NSRGFGFVNYRWL"
     gene            900..>1417
                     /locus_tag="KNP36_003758"
     CDS             900..>1417
                     /locus_tag="KNP36_003758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CRISPR-associated protein Cse4"
                     /protein_id="HBF0875553.1"
                     /translation="MVIGGENLLKDCLEIFEKEYKSLGNRLITDSYVLSYGTYILVKN
                     FSNIDILEVSKNNVDSTEDIYHKFCELDYLSKLVSIDKSVDSKKIIHSNNYLSFFVKK
                     ENLRPDKNNNVKLTEEIIDNYYDALLNPRIKYKSDKRKKEIYDSIENKYGKVDENKLN
                     KIRLWIKTNIFD"
BASE COUNT          627 a           99 c          210 g          481 t
ORIGIN      
        1 tctaaatata gaaattaaaa atgataaaga gattgtaatt atattttttt gaaactttgt
       61 gattttattt gtcgaataaa aaataaaaaa ttttaaagga aaaagttaaa aaataaagaa
      121 ttttataact ataaattata ttttagagtt tattgttatt aaatagatga aaaaatccta
      181 atatggatta tcagaaaatg aggaggttgt taattgataa aatgtcttga aatgtctgta
      241 aaagtgtatc ttcttgaaaa tatttcttta gataatacat caaaagaaat acgtaaatta
      301 atagatgata cattaattat agaagaaaaa tataaggaat ttcataataa agctggattt
      361 aagaattatt cttttaattt attataccca ttagaaaaag ataaggttta taagaaggat
      421 tgtatatata cttttattat tagaactgta gatagtgaat taggaatgta ttttatgaat
      481 aatttaaaaa atcagcattc tgataaaata aaggttatta caatgagtaa aaaagtgatc
      541 cctaaaaaac atatagaaag tatttactct gtcactccaa taatagctaa atttgaggat
      601 gggtattgga gaagtaataa aacagtagaa gatttagaaa aaagaatcag agaaaattta
      661 ataaaaaaat ataatgaatt tactaacagt aaaatagatg aagattttga attatttcaa
      721 gttattaaat ttataaatag gaaacctatt tctactaaat ataagaatat atctttactt
      781 ggtgataaaa taagttttaa agtatcagaa aatgatatgg ctcaggaaat tgcaaatttt
      841 gcacttggag ttggagtcgg agaaattaat tctcgtggat ttggttttgt aaactataga
      901 tggttatagg aggtgaaaac ttgttaaagg attgtttaga gatttttgaa aaagaataca
      961 aatctttagg aaatagattg ataactgata gctatgtcct atcctatgga acatatatat
     1021 tggtgaaaaa tttttcgaat atagatatat tagaagtttc taaaaataat gtggatagta
     1081 cagaagatat ataccataaa ttttgtgaac tggattattt atcaaaactg gtgtctatag
     1141 ataaatcagt tgattccaaa aaaataatac atagtaataa ttatctttca ttttttgtaa
     1201 aaaaggaaaa cttaagacct gataaaaata ataatgtaaa acttacagaa gaaattattg
     1261 ataattatta tgatgctttg ttaaacccaa gaattaaata taaatctgat aaaagaaaaa
     1321 aagaaatcta tgattcaata gaaaataaat atggtaaagt ggatgaaaat aaattaaata
     1381 aaataagact atggataaaa acaaatatat ttgattt
//
LOCUS       DAEHWM010000215         1344 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.218, whole genome shotgun sequence.
ACCESSION   DAEHWM010000215 DAEHWM010000000
VERSION     DAEHWM010000215.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1344)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1344)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1344
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.218"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            99..287
                     /locus_tag="KNP36_003759"
     CDS             99..287
                     /locus_tag="KNP36_003759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HBF0875554.1"
                     /translation="MAKVCSVCGKGKVSGNQVSHSNKHNKRTWSANLRSVRAIIDGAP
                     KRVKVCTRCLRSGKIERA"
     gene            complement(447..599)
                     /locus_tag="KNP36_003760"
     CDS             complement(447..599)
                     /locus_tag="KNP36_003760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxoglutarate translocator"
                     /protein_id="HBF0875555.1"
                     /translation="MRNNKSKVLLGILCLATGMAVILSMLLPGWIWSALTALILIGCG
                     ALLFFC"
     gene            complement(697..1173)
                     /locus_tag="KNP36_003761"
     CDS             complement(697..1173)
                     /locus_tag="KNP36_003761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004454873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HBF0875556.1"
                     /translation="MNLKRSNEKREEYRRMYSDKESFLSLIQNFTSVSIAKELTLKNI
                     ELETSFICEYKGKEVDIIYKVFSKSGKVSHYIVLEFQTEMDTEIVPRLKSYREQIWKS
                     FIMKKSLEEIEDKNFKLPKVIPVVLYSGPERLSRKKGILDIVESISEFSNNSSMKN"
BASE COUNT          445 a          208 c          163 g          528 t
ORIGIN      
        1 ggcaaatata tatttctatt gcaaattttt gttatttatg ataatataaa tatgttttta
       61 gtctttaaat agttatcatt ttaaggaggt gtgcgtagat ggcaaaagta tgtagcgtat
      121 gtggtaaagg taaggtttct ggaaaccaag tatcacactc aaataaacat aataaaagaa
      181 catggtcagc taacttaaga agcgtaagag cgattataga tggagctcct aagagagtaa
      241 aagtttgtac tagatgttta cgttctggta aaattgaaag agcttagtaa ccacgtttaa
      301 aagcctactt ccgtaagtag gctttttaat ttaatcattt ttactctttc tcataaattt
      361 taggattata cttgaaatcc attttggtaa ttttattgtt actactttca tcaatactca
      421 ccccacactt tatagttaaa actattttaa caaaaaaata ataatgctcc acatccaata
      481 agtattaatg cggtaagtgc tgaccaaatc cagccaggaa gcaacattga cagaattaca
      541 gccattcctg ttgctagaca aagtattcct agcaatacct tagacttgtt atttctcatg
      601 gaacacctcc acatagaacc tgtatctata aatattttca tattcaagtt tatgcgacag
      661 ttttccattt tagaccaata aacacattat gtaattttaa tttttcatac tagaattatt
      721 actgaactcc gatatagatt ctacaatatc caaaattcct ttttttctac ttaacctttc
      781 aggtccacta tataaaacaa ctggtataac tttaggaagt ttaaaatttt tatcttctat
      841 ttcttcaagg ctttttttca taataaaact tttccaaatt tgttctctat acgatttcaa
      901 tcttgggaca atttcagtat ccatttctgt ttgaaattct aacactatat aatgtgatac
      961 tttgccgctt ttagaaaata ccttataaat tatatcaact tcttttcctt tatattcaca
     1021 tataaaagat gtttctaact ctatattttt aagagttaat tcttttgcta ttgagacact
     1081 tgtaaaattt tgaatcaaac ttaaaaaact ttctttatct gaatacattc ttctgtactc
     1141 ttctcgtttt tcattgcttc tttttaaatt catacagttc ctcctagact atagaccttc
     1201 tattttttag taaagatagt ctataaattt tattttttaa ttttcactag tgagtattga
     1261 cagttgtgtg taaaatatcc agtaaagata tttttttata tttttattaa aagatataaa
     1321 tttttatatt ttaatgtatt gaca
//
LOCUS       DAEHWM010000216         1324 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.219, whole genome shotgun sequence.
ACCESSION   DAEHWM010000216 DAEHWM010000000
VERSION     DAEHWM010000216.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1324)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.219"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            358..612
                     /locus_tag="KNP36_003762"
     CDS             358..612
                     /locus_tag="KNP36_003762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009905281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875557.1"
                     /translation="MENKDFKLTICIFAFVIGVVVLFCCIGLGEFSAEHIIQQNGGIM
                     DTDQYNIYLDQSISQYRNFGSILALLGGIGILFDKYIRKY"
     gene            657..980
                     /locus_tag="KNP36_003763"
     CDS             657..980
                     /locus_tag="KNP36_003763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875558.1"
                     /translation="MATEIFTVKITPLEAQKMIKENLDADLVFSDSYNLGDDKFILIT
                     TFEKYYARNNSDAGLIVVYENTTGKTVIKATSTGSAIGILKIDWGAGGNLLKRVKNIL
                     ADYII"
BASE COUNT          549 a           93 c          205 g          477 t
ORIGIN      
        1 attagttaag gcatttgact atgatttaac tggagaagta gttcacttgg agagaaaaaa
       61 tggagacatt attaaagttt caattgtaca atagaattat tttatatgaa ttttattttt
      121 gaatagttat aaataattag aaatttgtaa aaaagtataa tatattatta gtaatggtac
      181 agaatacaca tttataattt atagatgtgt attttttgtt taaaaaattt aaatatataa
      241 aactataaag gttacaattt tggaaataga tgtaaatata tgttgtattg tataataaga
      301 gtaatataaa atctagtaaa aataatcaaa taaatttagc ttatgagagg gataactatg
      361 gaaaataagg attttaaatt aacaatatgt atatttgctt ttgtaattgg agtagtagta
      421 ttattctgtt gtataggttt aggtgaattt agtgcagagc atattattca acaaaatggt
      481 ggaatcatgg atactgacca atataatatt tatctagacc aatctatttc tcaatataga
      541 aattttggtt ctatattagc tctgttagga ggaataggga tattgtttga taaatatatc
      601 agaaaatact agagattatg ttttgtctaa aataaattct tatgaggaga taaaaaatgg
      661 caacagaaat atttactgta aaaattacac ccttagaggc acaaaaaatg ataaaagaaa
      721 atcttgatgc agatttagtt tttagtgatt cttataattt aggagatgat aaatttatac
      781 taattacaac ttttgagaag tattatgcaa gaaataatag tgatgcagga ttaatagtag
      841 tttatgaaaa taccacagga aaaacagtta ttaaagctac ttcaacaggc agtgcaattg
      901 gaattttaaa aattgattgg ggtgcaggtg gaaatttact taaaagagta aaaaacatac
      961 ttgctgatta tattatttaa ttattttatc taactgataa tatgtcaaga aaatctcgta
     1021 aaagaggtta agaacatttt tataatatat agataaataa gaatttgaag gtaaagtttt
     1081 taaggtataa agaaaaataa tataataaaa cgaattggct ttataattct ttataaggca
     1141 aagagcacat ttctttatat aattgttgga tattaaataa tatgtaaata caccatttac
     1201 atataaaagt ttaattaata tgttaagaga aaatgaaatg gaaattacta aaaaatattt
     1261 ttaaattgga taatggttga tattatgttt atacaaaaat catgtagaat tttatatatt
     1321 ttaa
//
LOCUS       DAEHWM010000217         1322 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.220, whole genome shotgun sequence.
ACCESSION   DAEHWM010000217 DAEHWM010000000
VERSION     DAEHWM010000217.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1322)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.220"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            240..1067
                     /locus_tag="KNP36_003764"
     CDS             240..1067
                     /locus_tag="KNP36_003764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AIM24 family protein"
                     /protein_id="HBF0875559.1"
                     /translation="MDLSKKVKILENASDGKSEFEILEFEKLEGASSPLMAMGLYFAR
                     EAGLKARQIKIKLNNSSIKTEAGALYYYKGNISSETKIGGVGGLFKKGISGALTNESM
                     MKPVYKGTGEVYLEPSFRHYLFMSLDNDSIIVDKGLFYCCSDTIEVKAFTQKNFSSAL
                     LGGEGFFQIELSGTGVIVLECVVPQSEIVEYELKNGEELKVDGNFAIARTSGVNFSVT
                     KSDKSLIGSALNGEGFLNTFTGNGTVWLAPTQVMYEKLSFGAMPTNDNMNNKVSKQK"
BASE COUNT          503 a          140 c          208 g          471 t
ORIGIN      
        1 ataattttaa catgcccata aaatataata cccacaaatg ataaataata ctcaaaatgt
       61 ctattgaaat aactatacat ccttaaataa cttaacttaa atctaaacat ttcaaaaact
      121 tcttaaaaat atgtaaaaat ttgatgataa agtagcgatt ttttcaaaaa aaatgtaata
      181 tagagttata tcttataata ttttagagat aaattttatc atagtgggga gaaatttgta
      241 tggatttaag caaaaaagta aaaattttag aaaatgcatc agatggcaaa agcgaatttg
      301 agatattaga atttgaaaaa cttgagggag cttctagccc attaatggca atgggattat
      361 attttgctag agaagctggt ttgaaagcta gacaaattaa gataaaatta aataattcat
      421 caataaaaac agaagctggt gcattatact attataaagg aaatatatct tctgaaacta
      481 agattggtgg tgttggaggt ctttttaaaa aaggaatatc aggagcactt actaatgaat
      541 caatgatgaa acctgtatac aaaggtactg gagaagttta tttggaacct tcttttagac
      601 attatttatt tatgagtctt gataatgatt ctataattgt tgataaagga ttattctatt
      661 gttgctctga tacaatagaa gtaaaagcat ttacacaaaa gaacttctca tctgctttac
      721 ttggtggtga aggcttcttc caaatagaat taagtggtac tggtgtaatc gttctggaat
      781 gtgttgtacc tcaaagtgaa attgtagagt atgaattgaa aaatggtgaa gaattaaagg
      841 tagatggtaa ctttgcaata gcaagaacat ctggtgttaa tttttctgtt acaaaatcag
      901 ataaatcttt aattggttct gctttaaatg gtgaaggttt cttaaataca tttactggta
      961 atggtacagt ttggctagct ccaactcaag taatgtatga aaaactaagt tttggagcaa
     1021 tgcctactaa tgataatatg aataataaag tttctaagca aaaatagttg ttttataaat
     1081 atttattaaa tcattattga ttttataaag tcactataaa ttttattaga ttattattat
     1141 aaaatcagag tgtggaaatg tttatgtgta ttctttaaat aaaaatttcc acattctgta
     1201 aggttattat acttgatata taaaattcaa tttaggaaca tagtctaaca tttataaaca
     1261 tattaaggta atgatttctc ttggtaatta ttctcatatc ttattctttg attatattta
     1321 tc
//
LOCUS       DAEHWM010000218         1293 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.221, whole genome shotgun sequence.
ACCESSION   DAEHWM010000218 DAEHWM010000000
VERSION     DAEHWM010000218.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1293)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.221"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..1108
                     /locus_tag="KNP36_003765"
     CDS             <1..1108
                     /locus_tag="KNP36_003765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="CRISPR-associated helicase Cas3"
                     /protein_id="HBF0875560.1"
                     /translation="KYADILNIKFIIMSATLPRLNKLGCNDDNFAYLVKNREKFFKNH
                     LFKDRVNISFEMLNSEINDIEEISEKVIEEAEIYNKILIEFIKKSSALKFYKNIKEKL
                     KYKLEDVFLLTGDDNKLERKKIINKIKDMNSVILVATQVVEAGVDIDMDLGFKDISTI
                     DSDEQFLGRINRSCKKLNSKVYFFNLDDASKIYKKDVRKERHLTLNEESNRKIILDKD
                     FEKYYDKIIARIEENKHKHNDKNIEVFIKDIVGNLNFTEVKKWMALIPDLKEYTIFLN
                     TIVKDESGNMIVGSDVWYEYISLLKNDNVEYSEKRVKMSEIMEKLDYFTYKVQKFDNS
                     FNDLVGDIFYIDDGSKYFTEGKFDRSKFNQNEFL"
BASE COUNT          561 a           75 c          213 g          444 t
ORIGIN      
        1 aaaatatgca gatatattaa atataaaatt tattataatg tctgcaactt tacctagatt
       61 aaataaatta ggatgtaatg atgataattt tgcatatcta gtaaaaaaca gagaaaaatt
      121 ttttaaaaat caccttttta aagatagagt aaacataagt tttgagatgt taaattcaga
      181 aattaatgat attgaagaaa tatcagaaaa ggttatagaa gaagcagaaa tatataataa
      241 gatactgata gagtttataa agaaatcatc agcactaaaa ttttataaaa atattaaaga
      301 aaaattgaag tataagttag aagatgtttt tttattaaca ggtgatgata ataaattaga
      361 aagaaaaaaa ataataaata aaattaaaga tatgaactct gtaattttgg ttgctacaca
      421 agttgtagag gctggagtag atatagatat ggatttggga tttaaagata tatctacaat
      481 tgattctgat gaacaatttt tgggaagaat aaatagatct tgtaaaaaat taaattcaaa
      541 agtatacttt tttaatttag atgatgcaag taagatatat aagaaagatg ttagaaaaga
      601 gagacattta actcttaatg aggaaagtaa tagaaaaatt attttagata aagactttga
      661 aaagtattat gataaaataa tagccagaat agaagaaaat aagcataaac ataatgacaa
      721 gaatatagag gtttttataa aagatattgt gggaaatttg aattttacag aggtaaaaaa
      781 atggatggct ttaataccag atttaaaaga gtatacaatc tttttaaata ctatagttaa
      841 agatgaatct ggaaatatga ttgtaggaag tgatgtatgg tatgaatata tatcactact
      901 aaaaaatgat aatgttgagt attctgaaaa gagggtgaaa atgtctgaaa ttatggaaaa
      961 actagattat tttacgtata aagttcagaa atttgataat tcatttaatg atttagttgg
     1021 agatattttt tatattgatg atggaagtaa gtattttaca gagggaaagt ttgatagaag
     1081 taaatttaat caaaatgaat ttctataatg tatttagatt atatagagaa tatttatccc
     1141 aagttaatta attagaatta gtttaaaact attgaaatat agatatttta tagcttatat
     1201 attttttcta ggattagctg ggataaaaaa tctgtatatt agtgttttca gtgtatttaa
     1261 ggggattata tttttaagaa gtactgattt taa
//
LOCUS       DAEHWM010000219         1259 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.222, whole genome shotgun sequence.
ACCESSION   DAEHWM010000219 DAEHWM010000000
VERSION     DAEHWM010000219.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1259)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1259)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.222"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(107..970)
                     /locus_tag="KNP36_003766"
     CDS             complement(107..970)
                     /locus_tag="KNP36_003766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003429634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0875561.1"
                     /translation="MSLVKNTSPDIIFANMTYKLISILIASILDFILWYSMNKIKEHI
                     YIITQNQIEFSLFLKFIWFTLGYILFDSIQITFAPPSSLTSYFILGSNILLILQLIIF
                     INHIYSIEKNIYLEKEHNRLKMIKQEQLLKVNLLKKKANIDELTSAYNRKFAFEKIQH
                     YIDNNLLFSLIYIDLDKLKTINDTYGHLAGDNYIINFSSIVIENLGIDDIFARIGGDE
                     FIVIMPKSNENTTKEFIEKISKIMDNTISFSYGIVEVSSENKMTVEEIINIADIRMYT
                     NKQNNHKRNNN"
BASE COUNT          451 a          135 c          152 g          521 t
ORIGIN      
        1 agagttatta atcattatgt ccagatattt aaaaaaatta taatgataga gataataaga
       61 taaaaaacat agtgagacta caagtaagct catgtaaata ttcattttag ttattgttcc
      121 ttttatgatt attttgttta ttagtgtaca ttctaatatc agcaatatta ataatttctt
      181 ctacagtcat tttgttttcg ctagaaactt ctacaatacc atagctaaaa gatatcgtat
      241 tatccataat tttacttatt ttctctataa attcttttgt ggtgttttca ttagatttag
      301 gcataataac tataaactca tctcctccta ttctagcaaa tatgtcatct attcctaagt
      361 tttcaataac tatacttgag aagttaataa tatagttatc cccagctaaa tgtccatatg
      421 tatcatttat cgtctttaat ttatccaaat cgatatatat caatgaaaat aataaattgt
      481 tatcaatgta atgctgtatt ttttcaaaag caaattttcg attatatgct gatgttaatt
      541 catcaatgtt agcttttttc tttaataaat ttacttttag taattgttct tgttttatca
      601 tttttagtct attatgttct ttttctaaat aaatattttt ttcaatggaa tatatatgat
      661 tgatgaatat aattagttgt aagattaata atatgttact tcccaatata aagtaggaag
      721 ttagagaact tggtggagca aatgtaattt gtatactatc aaataatata tatcctaaag
      781 tgaaccagat aaattttaaa aatagactga actctatttg attttgagtt attatataaa
      841 tatgctcttt tattttattc atagagtacc ataagataaa atctaaaata gaagctatta
      901 aaatactaat taacttatag gtcatatttg caaatattat atctggactt gtatttttaa
      961 caagtgatat tgtacttaca gtaataaggt gtaaaataca aaaacttatt actgccatat
     1021 tgggaataaa atggttgtta gtagaacttt ttctgcttaa gagcaattta tgacttacta
     1081 tgtaaaacaa tatataatat agtggtaatg gtaattttgt gaatattatt atcaagaagg
     1141 ttaatggttt tattaaaaaa atatatttgt aattcttatg tatagttata tttttgtttc
     1201 caaaagatgc tattttgcat atgtaaatgt tacatagttc gattattaat atagtagtt
//
LOCUS       DAEHWM010000220         1206 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.223, whole genome shotgun sequence.
ACCESSION   DAEHWM010000220 DAEHWM010000000
VERSION     DAEHWM010000220.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1206)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1206)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1206
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.223"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(226..1095)
                     /locus_tag="KNP36_003767"
     CDS             complement(226..1095)
                     /locus_tag="KNP36_003767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HBF0875562.1"
                     /translation="MVIIKAIELYKKLDLEFNIKNINDDWSFMNFENDFITPEFRKKY
                     IGLVLDNAQNINKVYTTTFPDKEIIKQVIDKDEKDILIFSHHAMGYIASDEGFPFHDI
                     PLSYMEEMKNRRISFYVLHSPLDNYSDYSTSVSFAKAMGLEIVKPFCKYDDKIEVGVI
                     CKTSLKSIEEIKELIKKSVGHDVKLYDYGDSVLKDGLVAIAAGGGSYPFVAREVAELG
                     INLYITGFTKPLKHFEPVLEFHQIAKDNLINVIGATHYSTEKFACMGMVDYFKNLGLE
                     SEFLQGKYYLEDL"
BASE COUNT          461 a          184 c          110 g          451 t
ORIGIN      
        1 accgtaaata ataatctaaa atacatcaaa aaataaacta aaaaatatcg aaaaataatt
       61 taaaagacat caaaactaaa tcttctaatc agcaattaaa agtctatttt cttagtttaa
      121 aaaataaaga tagatttttt caaaacactg gataaatagg taaaaaaata aacagttagt
      181 aaaataaatt tttactaact gtttattttt attgtttaat atgtcctata aatcctctaa
      241 gtaatatttt ccttgcaaaa attctgattc taaacctaga tttttaaaat aatcaaccat
      301 gcccatacac gcaaattttt ctgtagaata atgagtagca cctataacat taattaaatt
      361 atcttttgct atttgatgga actctaatac tggttcaaaa tgttttaaag gcttagtaaa
      421 cccagtaata tatagattta taccaagttc agcaacttct cttgctacaa atggataact
      481 tcctccccct gctgcaatag caactaaacc atcttttaat acagaatctc cataatcata
      541 caatttcaca tcatgaccaa cagatttttt aattaattcc ttaatctctt ctattgattt
      601 tagtgatgtt ttacatataa ctcctacctc aattttatcg tcatatttac aaaatggttt
      661 gactatttct aaacccatag cttttgcaaa actaacagaa gttgaatagt cactatagtt
      721 gtctagtgga gaatgtaata cataaaaaga aattctacga tttttcatct cttccatata
      781 agatagtggt atgtcgtgaa atggaaaacc ttcatctgat gctatgtatc ccattgcatg
      841 atgtgaaaaa attaaaatat ctttttcatc tttatctata acttgcttaa ttatttcttt
      901 atcaggaaaa gtagttgtgt atactttatt aatattttga gcattatcta atactaatcc
      961 tatgtatttt tttctaaatt ctggagtaat aaaatcattt tcaaaattca taaaactcca
     1021 atcatcatta atatttttaa tattaaattc taaatctaat tttttataaa gttcaattgc
     1081 cttaataata accactcctt tataataata ttgaattact acatattaat atagaaattt
     1141 ccgataataa actttatacg tttaagtatt cctacttcaa attaaaaata ttataaatat
     1201 tcaaat
//
LOCUS       DAEHWM010000221         1147 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.224, whole genome shotgun sequence.
ACCESSION   DAEHWM010000221 DAEHWM010000000
VERSION     DAEHWM010000221.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1147)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1147)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.224"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            67..1023
                     /locus_tag="KNP36_003768"
     CDS             67..1023
                     /locus_tag="KNP36_003768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CorA family divalent cation transporter"
                     /protein_id="HBF0875563.1"
                     /translation="MYILNLNTRETIEDFRDKFYVAENSYLILSAPKNLKLLKETLDI
                     DEITFNDCLKFDEITKLDLFDNYDFLSLNTFELRDGEAVIEEVNMYLSDNFILVVVNE
                     EHFLFEFVKNIILKNSQLEKNPVINLFKINYLILREVIKNGFESLEKVEELILQIEDE
                     MMDNINKNHVSRISDVRGLTRIIVKNTRPLLYIGDRIVKENIRYLKYSNVKKYNLENF
                     QGIDFGIDKLYNFALSTRELADKLLDIYSSRVGEKTNNLITKLTLLTAISAPLTIITG
                     IYGMNFRYMPELNWIYGYPATLFFMLCIIFVGIIIFKIKKLL"
BASE COUNT          476 a           91 c          168 g          412 t
ORIGIN      
        1 taaaataatt acagtaagga ttataaaaaa tttttagaat gtaaattgaa atttaggagt
       61 agatgtatgt atatactgaa tttaaataca agagagacta ttgaagattt tagagataaa
      121 ttttatgtag cagaaaattc ttatcttata ttaagtgctc caaaaaattt aaaattgctt
      181 aaggaaactt tggatataga tgaaataact tttaatgatt gtcttaaatt tgatgaaata
      241 accaaacttg atttatttga taattacgat tttttaagcc taaatacatt tgaactaaga
      301 gatggagaag ctgttataga agaggtaaat atgtatttat cagataattt tatattggtt
      361 gtagtgaatg aagaacactt tttatttgaa tttgtaaaaa atattatttt gaagaactct
      421 caacttgaaa aaaatccagt tattaatcta tttaagataa actacttgat tcttagagaa
      481 gttataaaaa atggttttga gtctttggaa aaagttgaag agttaattct tcaaatagaa
      541 gatgaaatga tggacaacat taataagaat catgtatcta gaataagtga tgtaagagga
      601 ttaacaagaa ttatagttaa gaatactaga cctcttttgt atattgggga tagaatagtt
      661 aaggaaaata taagatattt aaaatattca aatgtaaaaa aatataattt agaaaatttt
      721 caaggtatag attttggaat tgacaaatta tacaatttcg cattgtcaac acgagagtta
      781 gcagataaat tattagatat ttattcttcc agagtaggtg agaaaacaaa taacttaatt
      841 acaaaattaa ccttgttaac agccatatca gcaccactta caattataac tggtatatat
      901 ggaatgaact ttagatatat gccagaatta aactggattt atggatatcc agcaacttta
      961 ttttttatgc tatgtataat ttttgttgga attataatat ttaaaataaa aaaattattg
     1021 taaattacag atgatgttta attgatttta taaaaataca tcaattgaga agctgattta
     1081 agtaaataaa aaaatatttt aaattgaaaa tatttataga aaatattgac aattatattt
     1141 tctttgt
//
LOCUS       DAEHWM010000222         1114 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.225, whole genome shotgun sequence.
ACCESSION   DAEHWM010000222 DAEHWM010000000
VERSION     DAEHWM010000222.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1114)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1114
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.225"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(119..889)
                     /locus_tag="KNP36_003769"
     CDS             complement(119..889)
                     /locus_tag="KNP36_003769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBF0875564.1"
                     /translation="MSKGFLTPGETAQATISAGIKKANISTQNAILLGLFGGAFIGFG
                     ALGSMIVSQTFGKIDPGVASFLSAMVFPVGLMLVVVAGAELFTGNTLMAIALMDKKIT
                     LGKMLRNWGLVYFANLVGSILLVALVFYSSTLTGDAATKAIAVAEAKVNSTIASMFLK
                     AILCNILVVLAVWMATASQDIMSKLASCWTVIMLFVLCGFQHSVANMFFIPMGMALGA
                     NITMVQFITNLVFVTLGNIVGGSIVVGGIYYLCYVKNS"
BASE COUNT          410 a          205 c          119 g          380 t
ORIGIN      
        1 atataataaa gtaaaaaaaa aaaaataaca acatataaaa gaatataaat aatttaaaaa
       61 aagcatcaat atcactgata tcaatgcttt aaaaggcaat ttaattcgta ttatttatct
      121 aactattttt gacatagcaa agataataaa tccctccaac tactatggaa cctccaacga
      181 tatttccaag tgttacaaat accaaattag ttataaattg aaccatagtt atatttgctc
      241 ctaatgccat tcccattggt ataaaaaaca tgtttgcaac actatgttgg aatccacata
      301 atacaaatag cattattact gtccaacatg aagccaattt tgacattata tcttgagatg
      361 ctgtagccat ccatacagct aaaacgacta gaatattaca aagtattgct tttaaaaaca
      421 ttgatgctat agttgaatta accttagctt ctgccacagc tatagctttt gtagctgcat
      481 ctcctgtcaa tgtagaagaa taaaacacaa gtgcaactag caaaattgaa cctactaaat
      541 ttgcaaaata aaccagtccc cagtttctta acatttttcc taatgttatt tttttgtcca
      601 taagtgcaat agccattaaa gtgtttccag tgaataattc tgctcctgcc actactacaa
      661 gcataagacc tactggaaag accatagcac ttaaaaagct agctacccct gggtctatct
      721 tgccaaaagt ttgactaact atcatactcc ccaatgcccc aaaacctata aatgctcctc
      781 caaataaacc taatagaatt gcattttgtg tcgaaatatt tgctttttta atgcctgcac
      841 ttatagttgc ttgtgcagtt tccccaggtg tcaagaatcc tttactcata aatccttccc
      901 ccttaaaaat tatactttcc cttgtctttt tatggcaata attatataat aacaatatga
      961 tatataataa attttattaa cataaaaaat atactatata cttatatata cttgtctcat
     1021 ataattatac tatttattat ataacaactt tgttaatttc gaaataattt atattgaatt
     1081 tgaaaaattt accttttgat tatttatttt actt
//
LOCUS       DAEHWM010000223         1074 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.227, whole genome shotgun sequence.
ACCESSION   DAEHWM010000223 DAEHWM010000000
VERSION     DAEHWM010000223.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.227"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            109..1071
                     /locus_tag="KNP36_003770"
     CDS             109..1071
                     /locus_tag="KNP36_003770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009899252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HBF0875565.1"
                     /translation="MQAISDKFDANRKTISELRKKGNTKAKYPYKTKKFYIIPFKASA
                     INRNAKGNLKLSMSKGRYLELDFNVENIKTAEIVWRNGYYLYYTFDNELNGVVAKGTN
                     TVGVDLGEIHSIASVTNKGVGLILSNREGRSIKQFRNKMYAYISKRLSKCKKGSRQSK
                     KLWRLKNKIRSKTDNQLMNLYHQTTRKFIDFCVEQKVCEIVLGDIKGVEKDTKKKKRL
                     NRVNRQKISQMEYGRIKDYIKYKAKEQGIEVKLVKENYTSQTCPKCSKKHKPTGRTYS
                     CTCGYETHRDIVGAWNILNKKHKYGLVDFRINHKQPINLKVSTV"
BASE COUNT          475 a          110 c          185 g          304 t
ORIGIN      
        1 tacatagtta acttatctaa agaatactat tttgaacata aacaatggat taaaaagaat
       61 gatatacaaa agttaatcaa aggtaagtac aatcttcata gtcaaactat tcaagctata
      121 tcagataaat ttgatgcaaa tagaaagact atatcagaat taagaaaaaa aggtaatact
      181 aaagcaaaat atccatacaa gactaagaaa ttttatataa taccttttaa agctagtgct
      241 attaatagaa atgctaaagg caacttaaaa ttatcaatgt caaaaggcag gtatttagaa
      301 ttagatttta atgttgagaa tataaaaact gctgaaatag tatggcgaaa tggatattat
      361 ttatactaca cttttgacaa tgaattaaat ggagttgtag ccaaaggcac taataccgta
      421 ggtgtagact taggggaaat acattcgata gctagtgtaa caaataaagg tgtagggctt
      481 attctatcta atagagaagg cagaagtatt aaacaattta gaaataagat gtatgcttat
      541 atatctaaaa gattaagtaa atgtaaaaaa ggtagtagac aatcaaagaa gttatggaga
      601 ttaaaaaata agataagaag taaaacagat aatcagttaa tgaatttata tcatcaaaca
      661 actagaaagt ttatagactt ttgtgtagag cagaaggtat gtgaaatagt tcttggggat
      721 ataaaagggg ttgaaaaaga tactaagaaa aagaaaagat taaacagagt taatagacag
      781 aaaatatctc aaatggagta tggtcgaata aaggactata taaaatataa agcaaaagag
      841 caaggtattg aagttaagtt agttaaagaa aactacactt ctcaaacttg cccaaagtgt
      901 tctaaaaaac acaaaccaac tggtagaact tatagttgta cttgtggtta tgaaactcat
      961 agagatatag ttggtgcttg gaatatttta aataaaaagc ataaatatgg tttagtagat
     1021 tttagaataa atcataagca accaataaat ttaaaagtat ctaccgtttg agcc
//
LOCUS       DAEHWM010000224         1031 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.228, whole genome shotgun sequence.
ACCESSION   DAEHWM010000224 DAEHWM010000000
VERSION     DAEHWM010000224.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1031)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.228"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            97..849
                     /gene="cwlD"
                     /locus_tag="KNP36_003771"
     CDS             97..849
                     /gene="cwlD"
                     /locus_tag="KNP36_003771"
                     /EC_number="3.5.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003435644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase CwlD"
                     /protein_id="HBF0875566.1"
                     /translation="MEYYSVFISIHIQGDVVRKYIKHIIFSFAMICLVVVSIFEIKNI
                     SEDVIKYMPVTNKTIILDAGHGGIDPGALNKDKSTSEKDINLAITLKLRELIESSGGL
                     VILTREDDSSLYKEENNKTTRQKYNENLKNRKEIISNSNANMFVSIHLNAFEQSKYYG
                     AQTFYPKDKQDSKELSKCIQEELKRVVDKTNNREVKPRDDIYLLKENNIPSVLIECGF
                     LSNEKECKLLTDETYQEKIAWAIYIGIQKYLS"
BASE COUNT          458 a          108 c          157 g          308 t
ORIGIN      
        1 agggacagaa atataatatc attacataat aatatattaa taccaataaa taaagatata
       61 tcaatattaa aaaaatttaa atgtttgtac taatatatgg aatattatag tgtttttata
      121 agtatacata tacagggtga tgttgtgaga aagtacataa aacatataat ttttagtttt
      181 gcaatgatat gtctagtagt agtatccata tttgaaatta aaaatatttc tgaagatgtt
      241 atcaagtata tgccagtaac aaacaaaact ataattttag atgctggtca tggaggcatt
      301 gatccaggtg cattaaataa ggataagagt acatctgaaa aggatattaa cctagcaata
      361 acacttaagc ttagagagct tatagaatca agtggtggcc ttgtaatatt aactcgagaa
      421 gatgacagta gcctttataa agaagaaaat aataaaacta caagacaaaa atataatgag
      481 aatttgaaaa atagaaaaga aataatatct aattctaatg ccaatatgtt tgtctctata
      541 catcttaatg catttgaaca atcaaaatac tatggagctc aaacttttta tcctaaagac
      601 aaacaagaca gtaaagaatt atcgaagtgt attcaagaag aacttaaaag agtagtagat
      661 aagacaaaca acagagaagt caaaccaagg gatgatatat atcttttgaa agaaaataat
      721 attccatcag tactgataga atgtggtttt ttatcaaatg aaaaagagtg taaactctta
      781 actgatgaaa catatcaaga aaaaatagca tgggcaatct acataggaat acaaaaatat
      841 ttaagttgaa ataactataa aaataggtct aaatatgtaa atagcttgta ttaaagcagt
      901 taaaatgcat taatataggc tatttttatt ttgacaaaaa aatatttaaa ataaaagtta
      961 aaaagttgtt gacttagaat aatatagatg atattatata tgagtgccca aaaggagcac
     1021 caaaataaga c
//
LOCUS       DAEHWM010000225          990 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.229, whole genome shotgun sequence.
ACCESSION   DAEHWM010000225 DAEHWM010000000
VERSION     DAEHWM010000225.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 990)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 990)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.229"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            291..857
                     /locus_tag="KNP36_003772"
     CDS             291..857
                     /locus_tag="KNP36_003772"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
                     /protein_id="HBF0875567.1"
                     /translation="MRKLEEILEYNKSFVENKEYEQYVTSKHPNKKIVVLSCMDTRLT
                     ELLPKAMNLKNGDVKLIKNAGATIMHPFGSIMRSVLVAIYEFDVDEVMVVGHHGCGMC
                     NVDTDKLLGKILDRGISNDVILTLRSAGIDTKQWLHGFDSAEESVKDSIDLIKGHPLI
                     PDGIIVHGLIISPETGKLDVVVNGYEDK"
BASE COUNT          413 a           73 c          163 g          341 t
ORIGIN      
        1 ttaaatctaa ttatatatag gtgaaataaa aaattaatta taagtaaggc atttagaata
       61 aaattttaaa aaaattataa ttaaaaaaat aatgaaaata tataatatta gtttagatta
      121 taaaaaataa atatacaaat acttataaat acaagttata tacaagattt atagtagagt
      181 aataatctta taaaataatt taataaatat aaattaaatt atatgtgtat atattgtact
      241 ttaatagtga tataataata aaaaaatttt taaagagggt gatattacat atgagaaaac
      301 ttgaagagat attagaatat aataaatcat ttgtagagaa caaagaatat gaacaatatg
      361 tgacatcaaa acatccaaat aaaaaaatag tagtcttatc ttgtatggat acaagattaa
      421 ctgagctttt gcctaaggct atgaatttga aaaatggaga tgtgaaacta ataaaaaatg
      481 caggagctac tataatgcat ccttttggaa gtattatgag aagtgtttta gttgcaattt
      541 acgaatttga tgtagatgag gttatggttg tagggcatca tggatgtggt atgtgtaatg
      601 ttgatacgga taagttactt ggtaaaattt tagatagagg aatatctaat gatgtaatac
      661 ttacacttcg tagtgctgga attgatacaa aacaatggtt acatggattc gattctgcag
      721 aagaatctgt aaaagatagt attgatttaa taaaagggca tcctttaatt ccagatggta
      781 ttattgtaca tggtctaatt atatcacctg aaactgggaa gttagacgtt gttgtaaatg
      841 gatatgaaga taagtagagt atcataatgt tatataatca agatactgtt gaatatgatg
      901 ttgtttcaaa atttattttg ggacaacttt tttatttgaa aatatatgaa aaggtttatt
      961 ttaagcttta caataaaaaa tataagtagc
//
LOCUS       DAEHWM010000226          972 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.230, whole genome shotgun sequence.
ACCESSION   DAEHWM010000226 DAEHWM010000000
VERSION     DAEHWM010000226.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 972)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 972)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.230"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(467..643)
                     /locus_tag="KNP36_003773"
     CDS             complement(467..643)
                     /locus_tag="KNP36_003773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875568.1"
                     /translation="MFIGEIDKCTHILTAYISSSYDYCNFLDTQLDDFISEYGETVVE
                     TCLHQVLLLVSRYN"
BASE COUNT          361 a          105 c          125 g          381 t
ORIGIN      
        1 aaaacttata taaataaaat gcttgttttt cttgtattat ttatataaat attgaaattt
       61 gtctagttat acgtttttat tgaccagtta tgcagttgat attgaatatt ctaaatattg
      121 gtgttatttt ataggtggtt taaacatatt agggggattt tatatatgat ttgtatgatt
      181 tatagagaat gtataaaata gtaaaggttt agagccatgt ttagtggatt gcagaatatg
      241 catatagaat gattcttgta aattaagtta gacataggaa atatataatt tgtattggat
      301 gattaatttt atggtgtatg cttttaactt ctataatggg aaagtaaaga tgtactccca
      361 atacatcttt actttagcag aagttatagt tacttataaa gtacaaaaaa ttatatattt
      421 attagagtag ataaatctaa aaaggttttt ctagaaaaat ttagttttaa ttgtatctac
      481 ttactaataa taagacttga tgtaagcagg tttcaactac cgtttctcca tattctgata
      541 taaaatcatc taactgtgta tctaaaaaat tacaataatc atatgaacta ctgatgtaag
      601 cagttagtat atgtgtacat ttgtctattt ctccaataaa catattatcc atccccctaa
      661 aaaatttagt aaaaataaaa agtcgcattc tattagtcaa ttaacataat ttataaaatt
      721 ttttagtact agtttctata acttaactcc ttaaggttaa atattcccag ttttaccaat
      781 ttagttttat tctacaagta tataatacta gaagatgctc cattattcaa catgcttgtt
      841 tgagaataga aaatattcta aaattataat tgtttttaaa aataagattc aagataaata
      901 aagttatatg caactattta ataatctttc cataataagg acagtaggtt ctattcttaa
      961 aaaactccat ct
//
LOCUS       DAEHWM010000227          969 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.231, whole genome shotgun sequence.
ACCESSION   DAEHWM010000227 DAEHWM010000000
VERSION     DAEHWM010000227.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 969)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.231"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(701..841)
                     /locus_tag="KNP36_003774"
     CDS             complement(701..841)
                     /locus_tag="KNP36_003774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875569.1"
                     /translation="MENLMMSIITGVIASYIYDKLKSHSERPTKSGWELNIKFQKSKS
                     SK"
BASE COUNT          364 a          117 c           95 g          393 t
ORIGIN      
        1 gttgtaatct ctcaaatata aaaaaacaat aaattagctc attggatttt ttagtccata
       61 atataattat agattattca ccaaacaatc tatagaaatt gtggtattaa tgtttaaata
      121 accaactttt tctaaaataa cctttatagg aatatatgag ttcataagta aagatagcga
      181 aataagaaac cagtttggta tgtaaaatct agatttttaa ttaaattatc aagattatat
      241 attatagtat caaaaataga aaattaaaat taaatttttt ataataaatt gtatacatta
      301 taaattatat taaattttta atttaagtaa tagtatatgt aatctttagt catcttctta
      361 ccagtttttt atccactttt ctaatgaagt tattttttca tatgataatt cctcttgaaa
      421 taatgatact aaaagacttt ttataaaatt ataacttaaa agtttatgta tttttttgat
      481 atgaatttat agtacttatc ttctttaatt gagattgtgt atatttaact taaatattac
      541 atcaataatt ccatgcaatc aaatcaatta tttacatatt tttttagaac aataataagt
      601 atatattcac aaaattttgt gttaatattt ttaatttgtg atataataaa agcaaggaaa
      661 catattttac ttaactttga gtgatgtttc cttcaacaaa ttattttgaa gatttacttt
      721 tctggaactt tatattaagt tcccagccac tcttagttgg tcgctcagag tggctcttta
      781 atttatcgta aatgtaactg gctataacac cagttataat actcatcatt agattttcca
      841 tagttttcac ctcctctcat aagaaagtga agaaacttcc atggaaacac cactcatagc
      901 tttttcaaat atttattcct tgccatatta attatatcat aaatattgga aacataaaat
      961 tttaatact
//
LOCUS       DAEHWM010000228          897 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.232, whole genome shotgun sequence.
ACCESSION   DAEHWM010000228 DAEHWM010000000
VERSION     DAEHWM010000228.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 897)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.232"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(712..>897)
                     /locus_tag="KNP36_003775"
     CDS             complement(712..>897)
                     /locus_tag="KNP36_003775"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875570.1"
                     /translation="KDGTIVPPDTETKVTLVFTVTHTSSGKTADTGEIEVTVPARTTT
                     VSSLLGRIAVNIFNFNK"
BASE COUNT          346 a          103 c           98 g          350 t
ORIGIN      
        1 tattttttat tttcgatcta tttacttgaa ttttaacata aatctatctt ttagtatata
       61 ttaatcatgc tgaatttgtg atgacatgta tacaaaatat cgtttagtat tttctaataa
      121 aaaatattac tgaaattaaa aatctacaat agcatttaac aagtaaaaac atgtttacac
      181 aaatatataa tttaaggtct ttaaaataga gtatgtatta ttctaaaaat tagttatagt
      241 tatcacataa aaatagaaaa gaattttcaa aagatttaaa gaacatatat acttcaattg
      301 cagaagatgt aatgttaagt gaactagcat tcttcgagga aaaatagact caaaaaatta
      361 gaaaatagaa tcaggtttta gatgatttaa gtatttattt tcaaaaaaga aatttgattc
      421 taagttaata aagaaatatt taaaaaaatc aaaaaatttt cttaaataag taataggttt
      481 tgtaaaaatg gaaaaatatc aaaataagac tatgattttt aaaactatag ccttatcaat
      541 aaatttttat ttaaagaaca cacataaata tttttaaacc taatttatgt gaagttttat
      601 gtatttttta tataagtagt attctaatct tactcatcta atataccaaa aagactgtaa
      661 gtaagttcac ttttatgcaa acttacccac aatctctttt acacattaat tctatttatt
      721 aaaattaaaa atatttactg ctattctacc caataaagat gatactgttg ttgttctggc
      781 tggtactgtt acttctattt ctcctgtatc tgctgtttta ccacttgatg tgtgtgtcac
      841 tgtaaatact aatgttactt ttgtttctgt atctggtggc actattgttc catcttt
//
LOCUS       DAEHWM010000229          840 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.233, whole genome shotgun sequence.
ACCESSION   DAEHWM010000229 DAEHWM010000000
VERSION     DAEHWM010000229.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 840)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 840)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.233"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..211)
                     /locus_tag="KNP36_003776"
     CDS             complement(<1..211)
                     /locus_tag="KNP36_003776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0875571.1"
                     /translation="MLTNLSVGFWNIINLVSGTIDWIIFFLVIHLVGKRKISNIRYIF
                     TTIIIIIFMAYINVVKVFPNIKILLC"
     gene            complement(205..828)
                     /locus_tag="KNP36_003777"
     CDS             complement(205..828)
                     /locus_tag="KNP36_003777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003427906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875572.1"
                     /translation="MNYNIYEFSAGEELLNNYPKDLDILIMDIQMKTINGMDTARKIR
                     EFDHKLEIIFVTSFVEFMQEGYEVKAYRYILKPINKEKISKSVLPCINEMMKKRNNYL
                     TINVKNYVDRIKIDSITYIETDRPNILIYTHDDMYITKMSISKIEKILNEYGFFRCHN
                     SYIVNLKLVESMSGSTVIVDGKSIPISKYRVKGLKLAITNILGDIVC"
BASE COUNT          284 a          132 c           69 g          355 t
ORIGIN      
        1 tacatagaag aatcttaata tttggaaaca ctttaactac atttatgtat gccataaata
       61 taattataat tattgttgta aatatatatc ttatattaga tattttcctc tttccaacta
      121 agtggattac taaaaaaaat ataatccaat ctatagtacc tgaaactaaa ttaataatat
      181 tccaaaatcc tacacttaaa tttgttagca tactatgtcc cctaatatat tagttatcgc
      241 aagcttcaag cctttaaccc tatatttact tattggaata ctttttccat ctactataac
      301 agtacttcca ctcattgatt ctactaattt taagttaact atatagctat tatgacatct
      361 aaaaaatcca tattcattta atatcttttc tattttagat atactcattt tagtaatata
      421 catatcatca tgtgtataaa tcaatatatt cggtctatct gtttctatat aagtaataga
      481 atctatttta attcggtcta cataattttt tacatttata gttaagtaat tatttctctt
      541 tttcatcatc tcatttatac aaggtaatac acttttagaa attttttctt tatttattgg
      601 ctttagtata tatctgtatg cttttacctc ataaccttct tgcataaact ctacaaatga
      661 agtaacaaat attatttcta acttatgatc aaactctctt atcttcctag cagtatccat
      721 accatttatt gttttcattt gtatgtccat aattaatatg tctaaatctt taggatagtt
      781 atttagtaac tcttctcctg ctgaaaattc atatatgtta taatttatag gatatgaact
//
LOCUS       DAEHWM010000230          819 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.234, whole genome shotgun sequence.
ACCESSION   DAEHWM010000230 DAEHWM010000000
VERSION     DAEHWM010000230.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 819)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 819)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.234"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            267..737
                     /locus_tag="KNP36_003778"
     CDS             267..737
                     /locus_tag="KNP36_003778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009895702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase/bleomycin resistance/dioxygenase
                     family protein"
                     /protein_id="HBF0875573.1"
                     /translation="MKYQVSLLAVKDIEVSKKFYKELFEQEIELDLGKNVTFKGGFAI
                     QEDFAWLTGINPDTIIQKSNNMELYFEVDDFDEFIEKLNYYKDVEFVHKPLKHEWQQR
                     VVRIYDPDKHIIEIGESMEVIARRYLSEGYSVEETSKIIQHPIKFVKQCENSKE"
BASE COUNT          375 a           62 c          149 g          233 t
ORIGIN      
        1 acaaaagtgt taatagaaga tattgaaaac ataaaaacaa aagattgata gaaagtactg
       61 aatagataga gataaaagtg ttaatagaag atattgaaaa aataaaagat tgatataaga
      121 tactgaatag gtagaaacaa aagtgttaat agaagatgct aaaaaagtaa aaataaagga
      181 ttaataaaag gtactgaaga gatagagaaa aaaatgttaa tagaagatac tgaaaaaata
      241 gaaataaaaa attaggagga aaatttatga aatatcaggt ttcattatta gcagtgaagg
      301 atattgaagt atcaaaaaaa ttttataaag aattatttga gcaagaaatt gaattggact
      361 taggcaaaaa tgtaacattt aaaggaggat ttgctataca agaagacttc gcatggctta
      421 cagggattaa tccagataca attatacaaa aatcaaataa tatggaactt tattttgagg
      481 ttgatgattt tgacgaattt attgaaaaac tcaattatta taaagatgta gagtttgtcc
      541 ataagccact aaaacatgaa tggcaacaaa gagtagtgcg tatttatgac ccggataagc
      601 atattattga gataggagag tctatggaag ttatagctag aagatattta tctgagggat
      661 actctgtaga agaaacttct aaaataattc aacatccaat taaatttgta aagcagtgtg
      721 aaaatagtaa ggaatgattg tttaaattat aattatttag tagaaattaa ttgtaataga
      781 actaattcaa gataatatat aggactagta tttgacaaa
//
LOCUS       DAEHWM010000231          787 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.235, whole genome shotgun sequence.
ACCESSION   DAEHWM010000231 DAEHWM010000000
VERSION     DAEHWM010000231.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 787)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 787)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.235"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..>787)
                     /locus_tag="KNP36_003779"
     rRNA            complement(<1..>787)
                     /locus_tag="KNP36_003779"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          172 a          238 c          182 g          195 t
ORIGIN      
        1 cgtccatccc ggtcctctcg tactaaggac aggtcttctc aaatttccta cgcctgcgac
       61 ggatagggac cgaactgtct cacgacgttc tgaacccagc tcgcgtacca ctttaatggg
      121 cgaacagccc aacccttggg acctactaca gccccaggat gtgatgagcc gacatcgagg
      181 tgccaaacct ccccgtcgat gtggactctt gggggagata agcctgttat ccccagggta
      241 gcttttatcc gttgagcgat ggcccttcca cgcagaacca ccggatcact aagtccgatt
      301 ttcatccttg ctcgacctgt atgtcttgca atcaagctct cttttgcctt tacactctac
      361 gtacgatttc cgaccgtact gagagaacct ttgagcgcct ccgttacctt ttgggaggcg
      421 accgccccag tcaaactgcc cacctgacag tgtcccaaga ccagattcat ggcctatggt
      481 tagagtccca gtactacaag ggtggtatcc caaggatggc tccgccaaaa ctggcgtcct
      541 ggtttcaaag cctcccacct atcctgtaca tgtagtacca agacccaatg tcaagctaca
      601 gtaaagctcc atggggtctt tccgtcctgt cgcaggtatc cggcatcttc accggaatta
      661 caatttcacc gagtctgttg ttgagacagt gcccaaatcg ttacgccttt cgtgcgggtc
      721 ggaacttacc cgacaaggaa tttcgctacc ttaggaccgt tatagttacg gccgccgttt
      781 actgggg
//
LOCUS       DAEHWM010000232          783 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.236, whole genome shotgun sequence.
ACCESSION   DAEHWM010000232 DAEHWM010000000
VERSION     DAEHWM010000232.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 783)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 783)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.236"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            188..304
                     /gene="rrf"
                     /locus_tag="KNP36_003780"
     rRNA            188..304
                     /gene="rrf"
                     /locus_tag="KNP36_003780"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
     gene            310..398
                     /locus_tag="KNP36_003781"
     tRNA            310..398
                     /locus_tag="KNP36_003781"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:344..346,aa:Leu,seq:taa)
     gene            410..486
                     /locus_tag="KNP36_003782"
     tRNA            410..486
                     /locus_tag="KNP36_003782"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:444..446,aa:Ile,seq:cat)
     gene            596..>783
                     /locus_tag="KNP36_003783"
     rRNA            596..>783
                     /locus_tag="KNP36_003783"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          254 a          141 c          175 g          213 t
ORIGIN      
        1 attcattaag atatatgtgc agtttttaga gtgctaactc tatattttta aacttgtcaa
       61 aacttatgaa tttttaatag ttttataagg caaaaaatcg aataaaaaaa gtattgacac
      121 aataagacaa agatgttatt ataatacttg tcttagaaaa aaagttaaat gaaaatttag
      181 acaataatct ggttataata gcagagagga tacacctgtt cccattccga acacagaagt
      241 taagctctct agcgctgatg gtacttggtg ggaaactgcc tgggagagta ggacatagcc
      301 aggtgatgtg ccgaagtggc ggaactggca gacgcacagg acttaaaatc ctgcgggact
      361 tacctctcgt accggttcga ttccggtctt cggcaccaca aattattgtg ggccattagc
      421 tcagttggtt agagcgcccg gctcataacc ggtaggtctg gggttcgagt ccctgatggc
      481 ccaccacaat aatttaaaga actttgaaaa ttaaacagta ggttaattta taaacaagaa
      541 acaaaccata aagccagata ttttgataac aatagtatct gagcctgata aacttttatt
      601 tgagagtttg atcctggctc aggatgaacg ctggcggcgt gcctaacaca tgcaagttga
      661 gcgatttact tcggtaaaga gcggcggacg ggtgagtaac gcgtgggtaa cctaccctgt
      721 acacacggat aacataccga aaggtatgct aatacgggat aatatatttg agaggcatct
      781 ctt
//
LOCUS       DAEHWM010000233          763 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.237, whole genome shotgun sequence.
ACCESSION   DAEHWM010000233 DAEHWM010000000
VERSION     DAEHWM010000233.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 763)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 763)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.237"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(307..513)
                     /locus_tag="KNP36_003784"
     CDS             complement(307..513)
                     /locus_tag="KNP36_003784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003424507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875574.1"
                     /translation="MNQSQEKDLEFIKNHWDLTIIEKERNVTRIIRYSLIILAIIAFF
                     LPTKIKFSIYIFISLFCWLMYLVL"
BASE COUNT          298 a           70 c           97 g          298 t
ORIGIN      
        1 ttatctaatg cggcaatata atttaaagct ggtgttgtag aaaaactaag agtgaatata
       61 gcaaagagaa gcaatagtat tttaaacttt gtctctctta ttttttgaaa actaacatta
      121 aaacataagg tataaataat attatcatat aaatgaaaac aaatttgaat ttttctctgg
      181 tcgatgtata tagtaagttt gttgatatga gaaaaattat tattgataat atacatgcat
      241 agaaaggaaa tggtatataa tattttctta agtttctttt ttaggcattt ctattggcat
      301 tttaggctat agtactaaat acattaacca acaaaataat gaaataaata tatatataga
      361 aaacttaatt ttcgtgggaa gaaaaaaagc aataatagca agtattatta gagaataacg
      421 aataatacga gtaacatttc tttctttttc tatgatagtt aaatcccagt gattttttat
      481 aaattcaagg tctttttctt gactctgatt catttaatca tctcctgtta atagtataat
      541 tttaaagcta ttactttgtt ttattttaac atatttatac actaaagtga attttatgat
      601 tagatttatt taattatttc tgaattaaaa cttattagaa ttctctattt tgataatttc
      661 aaactctatt gattgtatga taattgaaac tataggatat gtaggataac aagtttcaaa
      721 gtagttaaaa taaaaaagat aatgatatta ttaatttaga ata
//
LOCUS       DAEHWM010000234          757 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.238, whole genome shotgun sequence.
ACCESSION   DAEHWM010000234 DAEHWM010000000
VERSION     DAEHWM010000234.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 757)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 757)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.238"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(84..>757)
                     /locus_tag="KNP36_003785"
     CDS             complement(84..>757)
                     /locus_tag="KNP36_003785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875575.1"
                     /translation="EASKTNLSTIVNPILTYITILLFVYGVNIANKDFSGALSIRADR
                     KSCIKAIVIDLIILSFVISILGIVLIFLSKLFIEIITGYSIELSVLLKRDMIWTSISA
                     LIDPSTSSMPLTYLNYFVQICINEICIGFIGVLLGAFTYRVRKVTSITILIGLPILMI
                     IYIVNFATKNMHKMLLYLEKIIYSFQNPFILFGTKVGIIVICIIFIILLLRKAPIKEY
                     ANDLL"
BASE COUNT          295 a          105 c           71 g          286 t
ORIGIN      
        1 taaaatcaac atttattaaa actaataaac ctgctttaaa atacaaattt acaaatttga
       61 tttttaagca ggttttattt tagttataat aagtcatttg catactcttt aattggtgct
      121 tttctaagta ataaaattat aaatattatg caaataacta taattcctac ttttgttcca
      181 aataaaataa aaggattctg aaatgaataa ataatttttt ctaaatacaa tagcatttta
      241 tgcatatttt tagttgcaaa attaactata taaattatca ttaatatcgg taatcctatc
      301 aatatagtaa tactagtaac ttttctaact ctatatgtaa aagctccaag taacactcct
      361 ataaaaccta tacatatttc atttatacat atttgtacaa aataatttaa ataagttagt
      421 ggcatacttg atgttgaagg atctatcagt gctgatatag atgtccaaat catatctctc
      481 tttagtaaaa ctgatagttc tatactgtaa cctgttataa tttctataaa taacttcgat
      541 aaaaaaatca aaactatacc taaaatagaa atcacaaagc ttaaaataat taaatctatg
      601 acaatagctt ttatacaact ttttctatct gctcttatac ttaaagctcc tgaaaagtct
      661 ttatttgcta tatttactcc atacacaaat agcagtatag ttatatatgt taaaatagga
      721 ttcacaatcg tggataaatt agttttagat gcttctc
//
LOCUS       DAEHWM010000235          753 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.239, whole genome shotgun sequence.
ACCESSION   DAEHWM010000235 DAEHWM010000000
VERSION     DAEHWM010000235.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 753)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.239"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..>753
                     /locus_tag="KNP36_003786"
     rRNA            <1..>753
                     /locus_tag="KNP36_003786"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          207 a          156 c          227 g          163 t
ORIGIN      
        1 tttaactgag cgttcagtta cttgacgtag acccgaaacc gggcgaccta cccatgagca
       61 ggatgaagcg aaagtaaaat ttcgtggagg tccgaaccca cgagcgttga aaagctcggg
      121 gatgacttgt gggtagcggt gaaattccaa tcgagcccgg agatagctgg ttctccccga
      181 aatagcttta gggctagcct caaggtgaga gatacggagg tagagcactg aatgtcctag
      241 ggggtattgc acctaccgaa gactatcaaa ctccgaatgc cgtcatctta tacttgggag
      301 tcagactgtg ggtgataaga ttcatagtcg aaagggcaac agcccagatc gtcagctaag
      361 gtccctaaat gtaagttaag tggtaaagga tgtgggattg cacagacaac caggatgttg
      421 gcttagaagc agccactcat tcaaagagtg cgtaatagct cactggtcga gtgatcctgc
      481 gccgaagatt tccggggcta aaacttacta ccgaagctac ggcatcagta atgatgggta
      541 ggggagcttc ccatacgggt tgaagcatga ccgtaaggac atgtggacag tatgggagtg
      601 agaatgttgg catgagtagc gagatgtggg tgagaatccc acaggccgta aacccaaggt
      661 ttccagggga aggttcgtcc gccctgggtt agtcgggacc taagctgagg ccgaaaggcg
      721 taggtgatgg acaacaggtt gatattcctg tac
//
LOCUS       DAEHWM010000236          664 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.241, whole genome shotgun sequence.
ACCESSION   DAEHWM010000236 DAEHWM010000000
VERSION     DAEHWM010000236.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 664)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 664)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.241"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..>664)
                     /locus_tag="KNP36_003787"
     rRNA            complement(<1..>664)
                     /locus_tag="KNP36_003787"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          152 a          191 c          151 g          170 t
ORIGIN      
        1 gatccagccg caccttccga tacggctacc ttgttacgac ttcaccccag ttattgattc
       61 caccttcgac gacttcttcc aaaaggttag ataatcggct tcgggcgtct ccaactcccg
      121 tggtgtgacg ggcggtgtgt acaagacccg ggaacgcatt caccgcagca ttctgatctg
      181 cgattactag taactccagc ttcatgtagg cgagtttcag cctacaatcc gaactgagag
      241 tagctttaag ggattagctc caccttacgg cttggcaacc ctctgtacta cccattgtag
      301 cacgtgtgta gccctaagca taaggggcat gatgatttga cgtcatcccc accttcctcc
      361 aggttatccc tggcagtctc tctagagtgc ccaacttaat gatggcaact aaagacaagg
      421 gttgcgctcg ttgcgggact taacccaaca tctcacgaca cgagctgacg acaaccatgc
      481 accacctgtc accaatgtcc ccgaagggaa ctctccgatt aaggagatgt cattgggatg
      541 tcaagcttag gtaaggttct tcgcgttgct tcgaattaaa ccacatgctc cgctacttgt
      601 gcgggtcccc gtcaattcct ttgagtttca ctcttgcgag cgtacttccc aggcggagta
      661 ctta
//
LOCUS       DAEHWM010000237          608 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.243, whole genome shotgun sequence.
ACCESSION   DAEHWM010000237 DAEHWM010000000
VERSION     DAEHWM010000237.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 608)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.243"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
BASE COUNT          240 a           46 c           71 g          251 t
ORIGIN      
        1 gtggtaaatt tatataaaaa agaatatgag ttgtaaaata ttaaataata ttgtactaat
       61 tggaataatt ttaactttat tatagattat tttaatacca ttagtactga tggtgtattt
      121 taaaattggt ataagcatta caaatacgaa tatgccaact gtaatatgta atataagtag
      181 ctatatacat atgtgctgtc ccatatattg tatcattgtt tatattaaaa agattatgta
      241 aattggtatc aatcaataaa tcattttcag aagaaatacc taaaaactta aaaaatacct
      301 atatgtgtat ttagttagat ttgagatttt tacatttaat tttatagtga caatattata
      361 ttatttttat gatgtctatt tatatgcaat tactataata tcagaactta tagtatcatt
      421 tgtttcatta tcaataaggt tttttacttt agttttgtca attttattaa aaaaagttat
      481 tgatataaaa gataagaagg ataaaactat atgacggatt tcaaacataa gagtggatat
      541 ttatataata gatattttat agttaatttt attagatttt atttaatact gtaatattaa
      601 tatcacaa
//
LOCUS       DAEHWM010000238          594 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.244, whole genome shotgun sequence.
ACCESSION   DAEHWM010000238 DAEHWM010000000
VERSION     DAEHWM010000238.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 594)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 594)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.244"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            2..75
                     /locus_tag="KNP36_003788"
     tRNA            2..75
                     /locus_tag="KNP36_003788"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:36..38,aa:Met,seq:cat)
     gene            90..166
                     /locus_tag="KNP36_003789"
     tRNA            90..166
                     /locus_tag="KNP36_003789"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:124..126,aa:Ile,seq:cat)
     gene            190..266
                     /locus_tag="KNP36_003790"
     tRNA            190..266
                     /locus_tag="KNP36_003790"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:224..226,aa:Pro,seq:tgg)
     gene            274..350
                     /locus_tag="KNP36_003791"
     tRNA            274..350
                     /locus_tag="KNP36_003791"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:308..310,aa:His,seq:gtg)
     gene            359..434
                     /locus_tag="KNP36_003792"
     tRNA            359..434
                     /locus_tag="KNP36_003792"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:392..394,aa:Lys,seq:ttt)
     gene            442..515
                     /locus_tag="KNP36_003793"
     tRNA            442..515
                     /locus_tag="KNP36_003793"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:474..476,aa:Cys,seq:gca)
     gene            522..593
                     /locus_tag="KNP36_003794"
     tRNA            522..593
                     /locus_tag="KNP36_003794"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:554..556,aa:Asn,seq:gtt)
BASE COUNT          134 a          141 c          166 g          153 t
ORIGIN      
        1 tggcggtata gcttagttgg ctagagcgtt cggttcatac ccgaaaggtc ataggttcga
       61 ctcctattac cgctactaaa atttaatgtg ggccattagc tcagttggtt agagcgcccg
      121 gctcataacc ggtaggtctg gggttcgagt ccctgatggc ccaccacatt aaattaatta
      181 atataaattc gaggtgtagc gcagtttggt agcgcacatg gtttgggacc atggggccgg
      241 gggttcgagt cccttcacct cgaccaatat aaggtgggta tagctcagtt ggttagagcg
      301 ccagattgtg gctctggagg tcgtgagttc gactctcatt atccacccca attcatatgg
      361 tctattagct cagtcggtag agcacctgac ttttaatcag ggtgtcccgc gttcgagtcg
      421 cggatagatc accaaaaagg tggcgacata gccaagtggt aaggcagtgg actgcaactc
      481 cttgatcccc agttcgaatc tgggtgtcgc ctccaaaata ttccaaggta gctcaacggt
      541 ggagcaaccg gctgttaacc ggtaggctgt gggttcgagc cccacccttg gagc
//
LOCUS       DAEHWM010000239          577 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.246, whole genome shotgun sequence.
ACCESSION   DAEHWM010000239 DAEHWM010000000
VERSION     DAEHWM010000239.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 577)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 577)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.246"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            <1..>577
                     /locus_tag="KNP36_003795"
     rRNA            <1..>577
                     /locus_tag="KNP36_003795"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          154 a          121 c          190 g          112 t
ORIGIN      
        1 caggatggac ccgcgtctga ttagctagtt ggtaaggtaa cggcttacca aggcgacgat
       61 cagtagccga cctgagaggg tgatcggcca cattggaact gagacacggt ccaaactcct
      121 acgggaggca gcagtgggga atattgcaca atgggcgaaa gcctgatgca gcaacgccgc
      181 gtgagtgatg aaggccttcg ggtcgtaaaa ctctgtcctc aaggaagata atgacggtac
      241 ttgaggagga agccccggct aactacgtgc cagcagccgc ggtaatacgt agggggctag
      301 cgttatccgg atttactggg cgtaaagggt gcgtaggcgg tctttcaagt caggagtgaa
      361 aggctacggc tcaaccgtag taagctcttg aaactgggag acttgagtgc aggagaggag
      421 agtggaattc ctagtgtagc ggtgaaatgc gtagatatta ggaggaacac cagttgcgaa
      481 ggcggctctc tggactgtaa ctgacgctga ggcacgaaag cgtggggagc aaacaggatt
      541 agataccctg gtagtccacg ctgtaaacga tgagtac
//
LOCUS       DAEHWM010000240          572 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.248, whole genome shotgun sequence.
ACCESSION   DAEHWM010000240 DAEHWM010000000
VERSION     DAEHWM010000240.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 572)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 572)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.248"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            104..565
                     /locus_tag="KNP36_003796"
     CDS             104..565
                     /locus_tag="KNP36_003796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003416014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875576.1"
                     /translation="MQIEQLDLETRNKIYCYTKKILRKYQKGITSGKLTADKFADNIL
                     SQDFISSILNEKIVNETNFKISYRNYIETLINIQNENLSNLRKKSTKTAKCFNISQIT
                     QLKNLLSNTGYNLLIPYKYLTARDIEGIVTLINTGSIELGNERIYNYISKV"
BASE COUNT          252 a           57 c           67 g          196 t
ORIGIN      
        1 atattttatt atttagtatt tattgtaaat aagttattga agcttgatta gttaagtata
       61 gatttttaat aaatattttt ataatttaga aggaagtggt tttgtgcaaa tagaacaact
      121 cgatttagaa acgagaaata aaatatactg ctatactaaa aaaattctta gaaaatatca
      181 aaaaggcata acatctggaa aattaacagc agataaattt gcagataata tattgtctca
      241 agattttatc agtagtatac ttaatgaaaa aatagtcaat gagacaaact ttaagatatc
      301 ttatagaaac tatatagaaa ctttaataaa tattcaaaat gaaaatttat ctaacttaag
      361 aaaaaaatct actaaaactg caaaatgttt caatatctct caaataaccc aattaaaaaa
      421 cttactaagt aatactggtt ataatttatt aattccatat aaatacttaa ctgctagaga
      481 tatagaagga atagttactc ttattaatac tgggtctatt gaacttggaa atgagagaat
      541 ctacaattat atatcaaaag tataataatt ta
//
LOCUS       DAEHWM010000241          568 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.249, whole genome shotgun sequence.
ACCESSION   DAEHWM010000241 DAEHWM010000000
VERSION     DAEHWM010000241.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 568)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 568)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.249"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            27..101
                     /locus_tag="KNP36_003797"
     tRNA            27..101
                     /locus_tag="KNP36_003797"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:59..61,aa:Thr,seq:tgt)
     gene            116..200
                     /locus_tag="KNP36_003798"
     tRNA            116..200
                     /locus_tag="KNP36_003798"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:150..152,aa:Tyr,seq:gta)
     gene            210..293
                     /locus_tag="KNP36_003799"
     tRNA            210..293
                     /locus_tag="KNP36_003799"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:244..246,aa:Leu,seq:tag)
     gene            323..399
                     /locus_tag="KNP36_003800"
     tRNA            323..399
                     /locus_tag="KNP36_003800"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:357..359,aa:Arg,seq:tct)
     gene            407..482
                     /locus_tag="KNP36_003801"
     tRNA            407..482
                     /locus_tag="KNP36_003801"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:440..442,aa:Gln,seq:ttg)
BASE COUNT          147 a          124 c          135 g          162 t
ORIGIN      
        1 ccccttccag gtcgccaaaa taaaatgctg gtgtggctca acggtagagc agctgacttg
       61 taatcagcag gttgtaggtt cgattcctat caccagctcc atgtaaaatt aatacggagg
      121 atttcccgag cggccaaagg gggcagactg taaatctgtt gtcatcgact tcggtggttc
      181 gaatccacca tcctccacca aaaaaatgcg cggatgtggc ggaattggca gacgcactag
      241 acttaggatc tagcgccatt ggcgtggggg ttcgactccc ttcatccgca ccatttttgt
      301 ttgatataca tatataaatt gtgggtgcat agctcagctg gatagagcaa cgcccttcta
      361 aggcgtgtgt ccggggttcg aatccctgtg cgctcaccac atatattggg gattagccaa
      421 gtcggtaagg cacatgactt tgactcatgt atgcgtaggt tcgagtcctg catccccagc
      481 caaatgatgt attactaagc tatatttgaa ttatttttat tttaaatata gttaggttca
      541 attttagaat aagtttaagt atccgaat
//
LOCUS       DAEHWM010000242          398 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.denovo.250, whole genome shotgun sequence.
ACCESSION   DAEHWM010000242 DAEHWM010000000
VERSION     DAEHWM010000242.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 398)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 398)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.denovo.250"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            complement(<1..396)
                     /locus_tag="KNP36_003802"
     rRNA            complement(<1..396)
                     /locus_tag="KNP36_003802"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT           94 a          108 c           65 g          131 t
ORIGIN      
        1 ctaaagtctt ctcgtttaac atacaggact attaccttct gtggtgggtc tttccaaacc
       61 tcttcaatta cgatacctct tcgttatgat atgtccgcaa ccccaataaa gaaaacttta
      121 ttggtttggg ctaatccgcg ttcgctcgcc gctacttacg gaatcgaatt tctttctctt
      181 ccttcaggta cttagatgtt tcagttccct gagttcccct cattaagcta tgtattcact
      241 taatgatact tagacattac tctaagtgag tttcctcatt cggaaatctt cggatcaaag
      301 tttacgtgca actccccgaa gcttatcgca gcttatcacg tccttcatcg gctcctagtg
      361 ccaaggcatc cgccctgcac ccttaataac ttgaccag
//
LOCUS       DAEHWM010000243        59577 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.guided.011, whole genome shotgun sequence.
ACCESSION   DAEHWM010000243 DAEHWM010000000
VERSION     DAEHWM010000243.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 59577)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 59577)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..59577
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.guided.011"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            372..710
                     /locus_tag="KNP36_003803"
     CDS             372..710
                     /locus_tag="KNP36_003803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423377.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875577.1"
                     /translation="MANIGKIIGDRIKVYRTKLGYSQEFLAEKAGLHPTYIGQIERAE
                     TNTSINIIMKIATALDIPLELLFANIITTEGVDNSVPLECYEMINKLTEKEQIAMLEL
                     IKCIIKYKEI"
     gene            732..1049
                     /locus_tag="KNP36_003804"
     CDS             732..1049
                     /locus_tag="KNP36_003804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HBF0875578.1"
                     /translation="MNYIGKRLKEERKKANLTSKEFANMVGVSPWYITQIESGKKNPS
                     LKTFIKFVNILNISADVLIKDITSTGKTYLENDINEELKDLNSRELNLISQIIDIIKK
                     NKI"
     gene            1199..1876
                     /locus_tag="KNP36_003805"
     CDS             1199..1876
                     /locus_tag="KNP36_003805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875579.1"
                     /translation="MIVIEGSDKFKIAKEYIDVEYTLFSKVTFRYEKLKFKDNAELEK
                     IKMFKYKNGYIPNKLNLSFGYGFSSYKKQIIRETVDTLRLTEIFSSENIEDIKFIKDG
                     TKKLEISIEKVVKFKRRKKRNYVCCYCPDMYRDIKLDKESINKIYNRKIKIEREVNIF
                     EDEDVIINKKVLKFPKSWTKNMQKYWLSENKYPIHSTVIDDDRYKCCNVQYTKNRVII
                     LYYIYNH"
     gene            complement(2204..2971)
                     /locus_tag="KNP36_003806"
     CDS             complement(2204..2971)
                     /locus_tag="KNP36_003806"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HBF0875580.1"
                     /translation="MKRKVQVKNITIGEGRPKICVPIIGKNKKDIIKEAKELKDACLD
                     IIEWRVDFFENVENIKEVKEVLYELRSYIHDIPLLFTFRSVVEGGEKLISRDYYTTLN
                     KEISNTGLVDLIDVELFMGDEVIDEVVNFAHKKEVKVIISNHDFNKTPKKEEIVSRLC
                     RMQELGADLPKIAVMPQNEKDVLVLLEATNEMFKIYADRPIITMSMSGMGVISRLCGE
                     IFGSALTFGAAKSVSAPGQISFKELNSVLNLLHKSIN"
     gene            complement(3643..4458)
                     /locus_tag="KNP36_003807"
                     /pseudo
     CDS             complement(3643..4458)
                     /locus_tag="KNP36_003807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897377.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
     gene            4559..5257
                     /locus_tag="KNP36_003808"
     CDS             4559..5257
                     /locus_tag="KNP36_003808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HBF0875581.1"
                     /translation="MYKLSYVVRVSTKNLDELKRRCDEVKDFYDDLSIKLVRPFGDML
                     GLHGEFIPVSKRYINDYIQYVTSDFLAGLGFGATQTLGEHEDIYLGYNLDTGKNVYLK
                     PALASQGVKGSITNALASAFIGSLGGGKLFSNNMLVYYAVLFGGQAVIVDPKAERGKW
                     KETLPEIAHEINIVNLTSNDENKGLLDPYVILSRKKDSESLAIDILTFLTGISSRDSD
                     KFLQKNDNWKIIME"
     gene            5345..5965
                     /locus_tag="KNP36_003809"
     CDS             5345..5965
                     /locus_tag="KNP36_003809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423956.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBF0875582.1"
                     /translation="MHLIDFMNEDIKKKLVKKTYKKKETILFAEQENEYVILMIDGIA
                     EAFILNVKGNISTIHLYRSGSFFGEMEQFNDGKKPVEIVAFTDCNVYKLHRDDFLNWL
                     RGDFEATKFLIREISSKLVVNAELIEELSSLSVKERLLRCISLHYYRSELNLLTKKQL
                     ASEVNAPIRSINRAINECVQEHLIAYENKRFSVINQREVLKNLPTT"
     gene            6121..6903
                     /locus_tag="KNP36_003810"
     CDS             6121..6903
                     /locus_tag="KNP36_003810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /protein_id="HBF0875583.1"
                     /translation="MTKTQQKMIQNVLEFSKRDSRIIGLAISSSYITKSLDEYSDLDF
                     LIVADDKSYEEVIEERLLIVEQFGTLVSAFTGEHVGEPRLIISLYDSPVLHVDFKFTT
                     LDGLLDRVEDSAILYEENNCITEIYSKKEAYFPTPDLQWIEDRFWIWVHYACTKIGRR
                     ELFETIDFLSFLRQSVLAPLIQLLLGKLPRGVRKIELDAPQYIEALEKTVANHEYKSC
                     VNALQATINLYLELREELSQSPIVRKVEAERVALQYFQDLIK"
     gene            7028..7954
                     /locus_tag="KNP36_003811"
     CDS             7028..7954
                     /locus_tag="KNP36_003811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875584.1"
                     /translation="MSDILSRITNKIGDKNIVDKLSALSKSDLNSLLLEVFDRQANTL
                     TATDILKSYQLNRFTIPSGIDPEEIHALESKLLRKAFNMDIKTIMLSPSAPLGSCSVF
                     GSVDQYNVVSALRGTETLADPSNMLAIIIADKLKRKEENNTIPIHMATTARVIRAQNF
                     VGKGLYSHFGLYCMVSSGIDTGSYTCEKMLLEKHLNYYKDILSEIENVRFSIILRKRN
                     GYKDNDGFFDRMVETIKLIFPNIELSIHNDDVDNNYYKGINFKLSVKQGNETVEIVDG
                     GFVDWTYQMLGNKRERCLISGIGLERFLVAVS"
     gene            7968..8417
                     /locus_tag="KNP36_003812"
                     /pseudo
     CDS             7968..8417
                     /locus_tag="KNP36_003812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729090.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            8777..9184
                     /locus_tag="KNP36_003813"
     CDS             8777..9184
                     /locus_tag="KNP36_003813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433840.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HBF0875585.1"
                     /translation="MVDEKTIEHQFDSFCKTVLRNYARDIYDENKRRNDYLVSLESLS
                     LAELSKLSILDDYDSNYICMVSYDYNIRIEDVLMAQAIGKLTKRKQDIILLSFFFNMT
                     NADIATLMDLAENTIHYHKTNALKELKELMQEH"
     gene            9186..9416
                     /locus_tag="KNP36_003814"
     CDS             9186..9416
                     /locus_tag="KNP36_003814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HBF0875586.1"
                     /translation="MKPTKEVLPFTIILLAVHGDVNAINVILKHFEHYIIRLSQKTLF
                     DEYGNPYIHVEEETKRMLGTKLITAILRFNLS"
     gene            9806..10009
                     /locus_tag="KNP36_003815"
     CDS             9806..10009
                     /locus_tag="KNP36_003815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262306.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HBF0875587.1"
                     /translation="MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKRADENLDSGWVI
                     MNSNRIQIKRKQFEKIVDTLDVI"
     gene            10087..10440
                     /locus_tag="KNP36_003816"
     CDS             10087..10440
                     /locus_tag="KNP36_003816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009897397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase DNA-binding domain-containing protein"
                     /protein_id="HBF0875588.1"
                     /translation="MSTEKRRDNKDRILRTGESQRKDGRYAYKYVYSFGKPQFVYSWK
                     LVPTDKPPKGKRDDISLRDKEKAIQNDLDDSIDTIGKKMTVCQLYAKKNGLRKNIRLN
                     TKKGRHYLMKILNKE"
     gene            10512..11144
                     /locus_tag="KNP36_003817"
     CDS             10512..11144
                     /locus_tag="KNP36_003817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CatB-related O-acetyltransferase"
                     /protein_id="HBF0875589.1"
                     /translation="MTIPSSNKVYPRSNDYQTVYLKNVITRENIEVGDYTIYNDFYND
                     PRDFEKNNVLYHYPINNDKLIIGKFCSIACNAKFLMTSGNHSMKSKSTYTFPIFYEEW
                     KLDINHITDAWDNKGNIIIGNDVWIGYDSIIMSGVNIGDGAIIGTRAVVTNDVPPYSI
                     VGGVPAKIIKKRFNNDTISKLLEIKWWDWPYKKIQSNIKHIQSGNIDKLV"
     gene            complement(11514..12383)
                     /locus_tag="KNP36_003818"
     CDS             complement(11514..12383)
                     /locus_tag="KNP36_003818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM protein"
                     /protein_id="HBF0875590.1"
                     /translation="MEYDMPLYRPPSEAYSLIIQVTLGCSHNKCTFCSMYKSKKFKIK
                     PLEVIKNEIDIFRRYYKHVERIFLADGDALIIPMEKLRDIILYIKEVFPECERITMYG
                     SPKSIEKKSDDELKELRKLGVKMIYLGLESGSNEVLEDIKKGFSSEQLIKVGRKVKKS
                     GIKLSATVIAGLGGTKKTHQHAVDTGKMLGAISPDYVGVLSLMVEPNTELYDLLKAGE
                     FTILEDKAVLQEIKEMIKNIDANEKIVFRSNHASNYANLKGVLPDDKQRLIDEIDYYL
                     SNQKLKREEYRRL"
     gene            complement(12480..13337)
                     /locus_tag="KNP36_003819"
     CDS             complement(12480..13337)
                     /locus_tag="KNP36_003819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HBF0875591.1"
                     /translation="MSKDVKVKRNKKYDTFSITMELERPLLYDEVENKDDKNNNRKFN
                     IKNKIFKGIGILFVLILLGFFIWINKTYEPQKLAKEALVSNSKVEVTVNENISFTPKG
                     RKVSKGLILYPGAKVEIESYAPLARKIAESGYEVVIVKMPLNLAILGTNKAQKVMDSY
                     NNIEHWVIGGHSLGGVAASNFARDNKLIEGVVFLASYPMGDELKELGKKVISIWGSKD
                     GVVNFKSLVESKQKLPDDTTYVEIEGGNHAQFGDYGKQKGDNDAIISQEKQLNITANS
                     IIKFLKNIS"
     gene            complement(13552..15570)
                     /locus_tag="KNP36_003820"
     CDS             complement(13552..15570)
                     /locus_tag="KNP36_003820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HBF0875592.1"
                     /translation="MTKKLVISKTKLFIFIIAFISIFIYLFGSKNTLIGVGIVTAMLT
                     LLERDLTISPIKNLLKYLAINIILGILSFFAVQNMYLGVLLNFIALFIIGYVFSYDLK
                     RAVYVPFGLMYIFMVSIPVGKSEFPMRLSALAVGAVIIMIAQFVMNRNRMKNVGDKEL
                     ISICDELLEKISLLKNTINDDSSIIKSSMRKIDSCNYRINSISKNLKMVIFDNRKDDF
                     YISIRGIDIMNILFSLERISLILERYKKDSKEFEDEDIKNILEESSINSKSDVLVVAT
                     KEINYIKMCLENKDTITDKEILGFRDYVIAQDTKNINLKEIYSVLENLYEFLVDYKKV
                     KSRDEKKAERKSKIPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLR
                     DGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLA
                     GYINSYVVDYRKLMVCVTVSALGSAVVMGDPNVLTISRISYVALGAIIALIVNKFILP
                     YDAKTGYQHVIEMYKGIVKNIIDEVNKSIENVADVYYIKNLLLIPSLIEDRLMLINAI
                     YKDKHQEDFLENQKLLISNMYNLYINVNKNKIKDEDVEKILRDTNYISNYNVDKYDEG
                     RSVILESIINTKSLGDKIICLNLLQTLNGVKEMYRISNITKVSIKEAA"
     gene            complement(15841..16617)
                     /locus_tag="KNP36_003821"
     CDS             complement(15841..16617)
                     /locus_tag="KNP36_003821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HBF0875593.1"
                     /translation="MHKETLDKLTNAAINKINLLNTSKVKYLVSSAFAGLYVGIGILL
                     IFTIGGLLTDAGSPMTKIVMGLSFAIALSLVIMTGTELFTGNNMVMSAGMLNKGVSIK
                     DTSKIWAYSWVGNLIGALVLGIIFVGTGLIDKGPVAEFFANTAASKASMPFTALFFRG
                     ILCNILVCVSVLCSFRTNSDTAKIIMIFLCLFAFITSGFEHSVANMTIYSVSLFSPTI
                     NTVTIGGAIYNLVAVTLGNIVGGALFMGLGTYILGKEKLN"
     gene            complement(16674..17645)
                     /gene="asrC"
                     /locus_tag="KNP36_003822"
     CDS             complement(16674..17645)
                     /gene="asrC"
                     /locus_tag="KNP36_003822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite reductase subunit C"
                     /protein_id="HBF0875594.1"
                     /translation="MIRDLNTKKVMKNAYRITKTKYETSLRVRVPGGLIDPESLAVVS
                     KIASEYGNGQVHITTRQGFEILGINMEDMEEINKIIQPVIEKMNINQSEKNAGYPAAG
                     TRNIAACIGNKVCPKAQYNTTEFAKRIEKAIFPNDLHFKVALTGCPNDCIKARMNDFG
                     IIGMALPIYEKDRCVNCGACVKKCSKISVGALKTENNKVVRDKDKCIGCGECVLNCPT
                     NAWTRDEKKYYRLAIMGRTGKKNPRLAEDFLLWVDEDSIIKIILNTYRYVEKYIDKDA
                     PGGKEHIGYIIDRTGFMEFKKWALEGVELPEITKMYENIYWSGIKYL"
     gene            complement(17658..18449)
                     /gene="asrB"
                     /locus_tag="KNP36_003823"
     CDS             complement(17658..18449)
                     /gene="asrB"
                     /locus_tag="KNP36_003823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrB"
                     /protein_id="HBF0875595.1"
                     /translation="MNPYIPVSAKILDIVKHTDKEWTFRVNCNTKGVLPGKFYEISIP
                     KYGESPISVSGYGEDYIDFTIRNVGKVTSELFNYKEGDSFFIRGPYGNGFDVSLYEGR
                     EIVVVAGGSALAPVRGIVEYFYNNKEKCEKFKLIVGFKSPKDILFADDLKRWSKKLDI
                     LVTVDGAEEGYSGNVGLVTKYIPELDMKDINNTSIVVVGPPMMMKFTVEEFLKRDLDE
                     KNIWVSYERKMCCGIGKCGHCKMDDTYICLDGPVFDYSYAKNLID"
     gene            complement(18450..19457)
                     /gene="asrA"
                     /locus_tag="KNP36_003824"
     CDS             complement(18450..19457)
                     /gene="asrA"
                     /locus_tag="KNP36_003824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009903096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic sulfite reductase subunit AsrA"
                     /protein_id="HBF0875596.1"
                     /translation="MKLKLDSSKFNEGLNYLKKDYKIFAPVLIPFKGTFSDTDVIRYK
                     EVNAFEEMEFAKKANFSPKEVVLPINQVLFYFTEKEFKESDLDNKKILIFLRACDING
                     IKRLDEIYLNNGEEKDYFYKNIRDKVKFALVGCKESFRNCFCVSMDSNKTDNYSIGLN
                     IEGDTLYLDIKDSEFEVFNGEATEFNVDYVTDNLISVDVPENIDSNEMIGNSIWDEYD
                     TRCIGCGRCNFVCPTCSCFTMQDIFYKENENVGERRRVWASCQVDGYTDIAGGNSFRK
                     KQGERMRFKTMHKIHDFKKRFGYHMCVGCGRCDDACPQYISFSKCIEKINDLVISKEE
                     V"
     gene            complement(19848..20537)
                     /locus_tag="KNP36_003825"
     CDS             complement(19848..20537)
                     /locus_tag="KNP36_003825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="HBF0875597.1"
                     /translation="MSKLKDYNIDKVIIFNNLSTKTKNQLKEKVKLKRLQKKEILFYE
                     KDSLDSVYILLEGKVSIFKISENGERKVIFILNSGEVINDITLDASKNSTVGCEAFEN
                     SIVAYYSIEEFLEIMQNDFQLTKDIISYMERRIRRLYRQLKNSISIKVDKKLAAKLYR
                     LSREFGVCCGEWTLLNVNITVTYLADMLGCKRETVSRMIKVLQKEELIKIDNKGFYVK
                     ETELSRYFKNN"
     gene            complement(20600..21448)
                     /locus_tag="KNP36_003826"
     CDS             complement(20600..21448)
                     /locus_tag="KNP36_003826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0875598.1"
                     /translation="MSILEQLESPTFKVTKSDKLLIAYIKENIDDVFYKPISQIAKES
                     NIGEATITRFVKKMNFNGLQDFKVTLAQEISTINKKNIINKNIQNDEPALDTAKKLLS
                     SNVTTLENTVEIINSKDVHDCARLIINAKKVYFIGIGYSGIIAQDSNYKFMRIGLNCV
                     SFDSSHTMIMMSSIMEEGDLIIAISHSGETEEIIKTVKLARANNAKIISITENKNSEL
                     KDISDVHLSYVSGETVLETGSISSKLAQFFIIDLVYTQVVKELSNEAIERKIKTTNAI
                     KLFKNE"
     gene            complement(21467..22354)
                     /locus_tag="KNP36_003827"
     CDS             complement(21467..22354)
                     /locus_tag="KNP36_003827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HBF0875599.1"
                     /translation="MKNYVCIDVGGTSIKYGFIREDGFIIDKSSLDTEAKEKGGEGIL
                     AKIKDIVKKYIEENEISGICISTAGMVDPVEGKILFALEELIPNYKGMQLKKEVEKEF
                     NIKCEVENDVNCAGLGEMWLGAGKDATSSICLTIGTGIGGCIIINNKLINGFSNSAGE
                     VGYMNVNGSSFQELASTSSLIKKVAKIKNLNENDLNGKIIFDLAKNNDEDCLKELDNM
                     IKSLAVGIANICYVINPEVVILGGGIMAQEKFLKPKIDKALKEVLIERVYKNTNIEFA
                     KRQNDAGMLGALYNFLNKI"
     gene            complement(22412..23215)
                     /locus_tag="KNP36_003828"
     CDS             complement(22412..23215)
                     /locus_tag="KNP36_003828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875600.1"
                     /translation="MENIDVFLLIGQSNARGLGNPKESIIPNENCFEYLSTDEIINMR
                     CELETSEGDGTIAPAFSNEWNKLTGNKVCFIHNAKDGSRIKNWNHDNNWFLNDTIEKF
                     NTGCTTLSKHYNIENKYVIWIQGESDAKYGSDVLYYKESLKKIAYRLKEECMIDKMFV
                     SLTGYWLGEDEYFIRTRRIAAAQESACSECDILCVGSKIAMQFHDRGLTIDDVHYTQE
                     GLNMLGEDLCKNIYKYHITKEKSVLSDTIDLSEARKYICELEKISKRFV"
     gene            complement(23375..23827)
                     /locus_tag="KNP36_003829"
     CDS             complement(23375..23827)
                     /locus_tag="KNP36_003829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HBF0875601.1"
                     /translation="MIFGNINHSKTYSTLHEDLLRCFEYAKDNSLIDYEKGTYTIDGD
                     DIFVNIVEYKTCEKEDRFWEAHKKYIDVHLMLDGCERIDINFIENLEQKIYEEKGDFL
                     PLDGKNNGYMELRKGDFLVCYPEDAHMTGIKVLEKENIKKAIFKVLVR"
     gene            complement(23957..25459)
                     /locus_tag="KNP36_003830"
     CDS             complement(23957..25459)
                     /locus_tag="KNP36_003830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003462875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:solute symporter"
                     /protein_id="HBF0875602.1"
                     /translation="MVGFTWIDFAILVVYLLAVLFAGLLFSKKEMKGKEFFKGDGTIP
                     WWVTSVSIFATLLSPISFLSLAGNSYGGTWILWFAQLGMFIAIPLTIKFFLPLYSRLE
                     IDTAYEYLEMRYESKGLRVLGALMFIIYQIGRMSIIMYLPSIVLAGLTGIPVNVLIIV
                     MGVIAIIYSYTGGLKAVLWTDFIQGMVLIVGVTGTLFYLIASINGGFGTVMDTLTTGH
                     KFLASNEVMFDKNILSTSAFIIFVGAGLNTFSSYVSSQDIVQRFTTTTDIKQLNKMTY
                     GNGVLSMGLATVFYLIGTCLFIYYTQNPDLAQTVQQDQVFASYIAYELPVGITGILLA
                     AIYAASQSTLSTGLNSVATSWTLDIQTIITKDISMEKQTKIAQYISLGVGILSIAVAI
                     VLANGEIKSAYEWFNSFMGLVLGVLAGIFVLGAFCKKATKMGAYVGFIVSAILVVYLK
                     YRMPEVTSWAYSLITITTSVVVGTIVSAIEAKVKAKVSLPKAETTVYYEK"
     gene            complement(25492..26358)
                     /locus_tag="KNP36_003831"
     CDS             complement(25492..26358)
                     /locus_tag="KNP36_003831"
                     /EC_number="4.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003452648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="HBF0875603.1"
                     /translation="MKGIYSALLVSFDKEGNINEKGLRQIIRHNIDVCKVDGLYVGGS
                     TGENFMLSTDEKKRIFEIAKDEVKEEIKLIAQVGSVNLKEAVELAKFTTDLGYDAISA
                     VTPFYYKFDFEEIKHYYNTIINSVDNRLIIYSIPFLTGVDMSLDQFGELFENEKIIGV
                     KFTAADFYLLERMRKTFPNKLIFAGFDEMMLPATVLGVDGAIGSTFNVNGVRARQIFE
                     LTKNEKISEALEVQHVTNDLITDILGNGLYQTIKLLLEEQGVEAGYCRQPMKEATDEM
                     KSRAKEIYRKYF"
     gene            complement(26443..27114)
                     /locus_tag="KNP36_003832"
     CDS             complement(26443..27114)
                     /locus_tag="KNP36_003832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003433825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HBF0875604.1"
                     /translation="MLDKVKGRLIVSCQALEDEPLHSPFIMGRMAKAAMEGGAVGIRA
                     QGVEDIIEIKKVTGLPVIGIIKRNYEDSDIYITPTKKEVDELLTTGCEMIALDATNRV
                     RPNNEDLKELIKYIKENGVLVMADISNYDEAIKAQEYGVDCVSTTLSGYTPYTKTLEG
                     PDFVLMERLVKDLEIPVIAEGKVNTPQDLKKVFELGVHSSVVGSAITRPQLITEKFVK
                     AIEIN"
     gene            complement(27387..27878)
                     /locus_tag="KNP36_003833"
     CDS             complement(27387..27878)
                     /locus_tag="KNP36_003833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0875605.1"
                     /translation="MEGNTNNKVDDKFSKVKKKFGSGKFKVELYKEKSKLNREIDDIQ
                     EKKAKIFLEMGILTYQKIREDSINDNSFDKFCDELLELDKLIYEKNMEINEMEMAESN
                     VTCECGYVGNVNDKYCAECGKKFELENECDDFIICGYCESEIDTEAEFCPCCGRKIIM
                     DLE"
     gene            complement(27900..29264)
                     /locus_tag="KNP36_003834"
     CDS             complement(27900..29264)
                     /locus_tag="KNP36_003834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="HBF0875606.1"
                     /translation="MGEKKINNMNYSHNNYSKKTGEPTRKIKNSHITLKSKEEKICSS
                     CNKENNTKDNYCKFCGNELYEIASLRPLETKLDLKSKIKELSYHANKRGVFLTTFTTI
                     FILFIIALIFKAIITIQFNDISYLINPAHIILALNLGQISVSMSTMMGSGFINANIGL
                     LILLIIPILVLLISNLIFMRKRCRDSKTVLANSLGVGIFYGLVLAILSIFTNVKTSSH
                     SMLEYGYALEYSYEFFSVLLNGFVLGFICTYITTYKKSYEKENMYLSLFSNSIRTFIL
                     GYVLVLVILLVLTISDSSYLNELDMSSYSNGLNLFTILPQIASYMWAFANGISVTIIN
                     STVSMFTLSSSSLFGDTKLMFYAMGALSMLILLLNGYKLRFKYNTDSIRPIIVFSIYY
                     AFLMGILALFSTFILDSNINFFNTTNYGTTLIMQFKVLQAIVISFVYSFVISLIGYKL
                     NSAD"
     gene            29683..30858
                     /locus_tag="KNP36_003835"
     CDS             29683..30858
                     /locus_tag="KNP36_003835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009893536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GGDEF domain-containing protein"
                     /protein_id="HBF0875607.1"
                     /translation="MNLEKIKKFFGFPLDKKHKDNVEKELCNYLYHTGKIICIIIVIS
                     QIIMMISISAREGGPFVTPRRQWYFYMYVTLFCVSSVFMFVFSYLWNKKKDCCTFYIN
                     LWIIYVTFFCLWGCVITLLDQLGGNDLSVFSYIMLAAAAFSVLKFGESVIVFGGCFLF
                     LNLFLPGIQTIPGNEFSNIVNTFFITSLAIFVSTMLYRNRVFTYYDKLLISQQYEEIS
                     HINNLLNDKVMTDDLTKMNNRRYLEDILQKKLISHANQEPITGMMIDIDYFKQFNDNY
                     GHQKGDYCLQNIAKVILDFTSSENEHAIRYGGEEFFICIFNCNEADAKLKSECLRKII
                     ESCNFERDDVPLKCVTVSIGVYTKKIGKTITLNEFISNCDKALYTAKEQGRNCVAFY"
     gene            complement(31031..32428)
                     /gene="asnS"
                     /locus_tag="KNP36_003836"
     CDS             complement(31031..32428)
                     /gene="asnS"
                     /locus_tag="KNP36_003836"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HBF0875608.1"
                     /translation="MQKEFITVKELYREKEQYIGKTVKVAGWIRTSRVSKNFGFIELN
                     DGSFFKNMQIVFDEKVENFKEVGKLAISSSILVEGELVSTEGAKQPVEIHAKSIVVEG
                     ESDSSYPLQKKRHTLEYLRTIAHLRPRSNTFSAVFRVRSIAAYAIHKFFQERNFVYAH
                     SPIITGSDCEGAGEMFRITTMDLNDIPKTEDGKIDYTQDFFGKEANLTVSGQLNAEIM
                     ALSFRNVYTFGPTFRAENSYTGRHASEFWMIEPEIVFADLEDNMELAEDMIKYVISYV
                     LENAPEEMEFFNSFIDKGLLERLNKIVNSEFIRITYTKAVELLIESGHEFEYPVEWGC
                     DLQTEHERYITEQIYNCPVFVTDYPKDIKAFYMRMNEDGKTVRAMDLLVPGVGEIVGG
                     SQREEREDVLLDRINEMGLREEDYWWYLELRKFGTATHSGFGLGFERIIMYMTGMSNI
                     RDVIPFPRTPKNAEF"
     misc_binding    complement(32505..32738)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(32907..33101)
                     /locus_tag="KNP36_003837"
     CDS             complement(32907..33101)
                     /locus_tag="KNP36_003837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3787 domain-containing protein"
                     /protein_id="HBF0875609.1"
                     /translation="MESKKARALKGKDNKRLKSSLLVGNESTAAWADVEKLKPHSKVS
                     IPSIKGVEEAKDWVDNGSKL"
     gene            complement(33374..35047)
                     /locus_tag="KNP36_003838"
     CDS             complement(33374..35047)
                     /locus_tag="KNP36_003838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HBF0875610.1"
                     /translation="MEKSYCIIYQGDIESALQENGINRYMVLNSQLAVIYVPLDFDET
                     ILNNIIQVAWWEESEPMSSLIEITNNVNNGETITTAAETDYIYENPYNDITGRGILLA
                     VIDSGIDYLHPDFINDDGTSKVLYLWDQEANTNPPPEGFIFGSEFTRSELNIAINRND
                     GSLSQDNIGTGTLVSGILVGNGRINSQYRGITTESDLIVVKLKSYTDTYYAGRINYSV
                     SDFLAAITYVTNIARTENKPLIINLTIGVKSSAVATTSILDTFNILSSAGVVVVSGAG
                     NQGNTDIHYSGRFSSVGEVQDVIIQDGDDYALDITLNTNGPDKVGAQIISPSGEVSHD
                     IRYSPDFYIYRGKFNLENTTYAMRFIYPYITSGKENLEIRLRDIKPGVWILRLTSELI
                     INGEYDIYLPNKNLIAPDTRFLEPDSVATITMYAASDDVITVGTFNNKTDSMWIGSSK
                     GPIRGRGIKPDIVASGVDIISTYKNGTYNTGTGTGVSSSIVTGVLALLMEYLEKQDNV
                     PRLSLFTQVLKTYLILGATKLEIYTYPNVSQGYGILNLKNTIQQIANTL"
     gene            complement(35057..38455)
                     /locus_tag="KNP36_003839"
     CDS             complement(35057..38455)
                     /locus_tag="KNP36_003839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018112792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HBF0875611.1"
                     /translation="MIIINYELIVKYNGDILRLEEELGVSVEILNSSYAIITSSNEED
                     VNILLTYPEIEFIEKPFILQTQDVQSFSSTGITGFKNRTGLTGKGTIIGIIDSGIDYT
                     LPVFRDSDGRSKILYYWDQSIQGNPPEGFREGTLYTNEDINNAIDGSMYIPISTTSLH
                     GTHVAGICATIASDARIIVVRVGNIQTDIFSRSTEFMRAIKFILDRALELRMPVTLNI
                     SYGSNEGSHRGTSLFEQYIDDMCLFWKNNIVVAAGNNADKGGHKRIRLQNNITEEVEF
                     IVGEGERILNINIWPDFVDDFSVHLVNPSNNQTQAISLTSGEIRNTLGETRITGYFYP
                     IAPYSLTRRVTLQLSSNTQITPGLWKIVFEPIDIVTGNVNIYLPTSEGLNRNTRFLIP
                     TQELTVTVPGTASRVITVGSFNSRTDIVSIFSGEGDTQLGVFKPDLLAPGEDIVSFLP
                     GGTSGALTGTSMATPHVTGVCSLFMEWGIVNGNDLFLYSQKLRALLLKGARRLSNQSY
                     PNNSSGFGFLNLSDIDLYTLSNINQDLETEDIGYRSINKSFKDEENSYKFIDGYNMQI
                     HNDLENEIYISKNASRQSGILSGIDIVHTPEFEEELAGLGMSQRFFKISDSLGVLSIN
                     NTDYNSIQRVLQLPSIIRTVSTTKMTLLGEINRGTFGGVVATEEMGVNFFKNNPNINI
                     TGRGTLISIADTGIDYLHPDFIYPDGTSKIVYLWDQTKEGTPPDGFYIGTEYTREDIN
                     RAIAENDPSLSQDEVGQGTMLSGICAGLGNVNSEYAGIAEDSELIIIKLGKIDDFYNS
                     AMLFAASQYAYKKAFELGRPLVINMSLGTSSLAGLTNRSNSEKAFFTRGLCITAGAGN
                     EGNTQTHTSGIIPYVGGSVEVELELNEDEEELSLELWLNRPDKADVIIVSPTGEESKS
                     VGISNYNKVTGLFDLEGTEYSITYIYPTTFSGQQFTNVTLKNAKRGVWKIRLVGVYII
                     TGRYNLYLPNRELLKSGTRFREVDPFYTINYPAIQDDLITIGAYNTINGSLWQSSSRG
                     PTIEDRLKPDIVAPGVNIIAAYPGNTYATITGTAAASAHAAGAAAMYFQYTFVDGRYP
                     NQAYVQKIKTFMQAGARKDSNTVYPNTNSGYGLLDVRGMFDVLR"
     gene            complement(38622..39818)
                     /locus_tag="KNP36_003840"
     CDS             complement(38622..39818)
                     /locus_tag="KNP36_003840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011861504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VWA domain-containing protein"
                     /protein_id="HBF0875612.1"
                     /translation="MFIEFFYLLRSRGLNVSLNEWMTLIEALDKGLCYSNFSNFYYLC
                     RMILIKSESDFDKFDAVFLEYFKGIEHQEEIPEEIMNWLKKPDIDLEEFERLEQNPNI
                     NLDKLRAKLEERIKEQDSPHNGGNYWIGTGGTSELGHSGKGQTGIRIGGNSTYGRAVL
                     EVAGERKYRDFRDDEVLNMRQFQVALKRLRQFSTRIDAPKTELDLDKTIEETCNNAGY
                     LKLFFEKPRKNTVKLLLLMDSGGSMRGYSTLCNTLFQSVSKSNHFKDVKIYYFHNCIY
                     DRLFTTPECWLSKSINTEWILKNIDKNYKVIIVGDASMSPSELLHIGGNYRGPYNYTP
                     GIEWLKRFKRKYSKIVWMNPELRDGWDSISYWYQTQRMIQSEFNMFPLTVKGLEKALK
                     NLMVSR"
     gene            complement(39839..40660)
                     /locus_tag="KNP36_003841"
     CDS             complement(39839..40660)
                     /locus_tag="KNP36_003841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MoxR family ATPase"
                     /protein_id="HBF0875613.1"
                     /translation="MIKKEISNFRGSSDYVVSPELMASVNVAIALEKPLLIKGEPGTG
                     KTMLAQAISNELKKDLVIWNIKSTTKAQEGLYVYDTVQRLYDSQFGGEGVDDISKYIK
                     YGKLGEAFSSNQQVILLIDEIDKADLEFPNDLLWELDKMEFYINETKETVRAKQRPIV
                     IITSNAEKELPDAFLRRCIFHYIEFPDRDMMEEIVKVHFDKVEEHLLEQVMTTFYWIR
                     SLKDIQKKPSTSELIDWIQALTLSGMPIEKIEKEVPFAGILLKNNEDIESMQRHL"
     gene            41124..42218
                     /locus_tag="KNP36_003842"
     CDS             41124..42218
                     /locus_tag="KNP36_003842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HBF0875614.1"
                     /translation="MQDKKIYLNIVLTVVVSYILIKVIDNYKYFFGVISLLMSLLTPF
                     IIAFVLAYIFNPLVKFLESKLNFKRIYSLLLTYGVLIVILISFILFTVPSIVNSLADL
                     VAQIPTYIDKTEQFLFDLGKSLQSVDPNTLKEYGDKIMSVMPKFSNLLIGSLGGIFST
                     TFSVGKFIVQFLLGFIICFYILLEKEKFLLFTKKVVYISLGKKYGDFIIELCQSLNLN
                     IGKYFTGKILDSFIVGVLSGIGLYFLKSEYALLFGTLMGVMNMVPYFGPVIGMAPVVI
                     INLFSNPTIALTSLIYLIIIQQVEVTFIEPKIVGGQLGLSPFFTILAVTVGGGFFGIP
                     GMILSAPVMGVIKIYFCEFVNRRHDKIQME"
     gene            42369..42725
                     /locus_tag="KNP36_003843"
     CDS             42369..42725
                     /locus_tag="KNP36_003843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009890447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875615.1"
                     /translation="MKKALISLLVLSCLLLTAPVNESSYADSQKNVPVSQNTKLTQEQ
                     AKELLVKYNNEVDYIYQGNASDFEALKAKNLNGYVFLPDADGDIGYFVNENTSEIYYF
                     HPSGYLELVNQQQNNK"
     gene            complement(42818..44086)
                     /gene="eam"
                     /locus_tag="KNP36_003844"
     CDS             complement(42818..44086)
                     /gene="eam"
                     /locus_tag="KNP36_003844"
                     /EC_number="5.4.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 2,3-aminomutase"
                     /protein_id="HBF0875616.1"
                     /translation="MNEQTRISLERAAELKSKIDDYIQARKTINRGLEKEEEINKRKQ
                     KILSILNGTEEDWNNYKWQLSNRITDVDTLSKIITLTKKEKEYIKEVGTQFRWAISPY
                     YLSLIDPEDTCDPIKLLSIPTHIELEDEQEDLDPMGEEYTNPAGCITRRYPDRLIINV
                     TNECAMYCRHCQRRRNIGQQDSHKSKAIIQESIDYIRENEEIRDVLVTGGDALTLKDD
                     YLEWILSQLKEIPHVDYVRLGTRTLVTMPQRITDEFCNMLKKYHPVYINTHFNHPMEI
                     TKESKEACEKLANAGVPLGNQAVLLNGINNDKFVMRCLNQELLKIRVKPYYIFQSKHV
                     KGTKHFNTSVDDGLEIMEYLRGYTSGMAIPTYIVNAPKGGGKTPLLPQYLVSKGTDYV
                     MLRTWEGKVIKMEDEPAVDIKKLIKEQAQD"
     gene            complement(44488..45870)
                     /locus_tag="KNP36_003845"
     CDS             complement(44488..45870)
                     /locus_tag="KNP36_003845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016729078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HBF0875617.1"
                     /translation="MPINSFENYPMTWKPKLDNRKPPIYKTLAMLLEEDIKRGNLNPG
                     DKLPPQRELADFLDLNLSTITRAFKLCEEKGLICAKVGKGTFISSDVNVSNTLLYQTE
                     SKDIIELGTVHPPYEQNTYIIDFIKNVLKQPEMDRFLQYMSPSGTYMQKKSIAKWIER
                     NNVYTSEENILLSTGGQNAICATLLGLFKAGDRIATDSLSFSGIKSIAKMIGIQLVPI
                     PQENNEISIEYLESYCKNENIKGIYLIPDYHNPTTHTMSDLSRKKIAKIAKQYNIIII
                     EDAINSIFRDGIQTPIFSLASDNTIYIFSTSKFLCAGLRVAFVVAPKRYIENLENALY
                     NMNLMVSPFTAEIVHRLLYSPIIDKIIEEKRDAIIERNEVADKVLSDYNLIGDKNCSF
                     RWLLLPDELDGKSFEISAKNLGVQVYCAERFSVGNSTVPKAVRICVTAPKDVEELEKG
                     LNIIKSLLKS"
     gene            45995..46681
                     /locus_tag="KNP36_003846"
     CDS             45995..46681
                     /locus_tag="KNP36_003846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="HBF0875618.1"
                     /translation="MKTIGLIGGMSWESTITYYQVINTVIKERLGGLHSSKCILYSVD
                     FQEIEECQSSGNWEKSAKILADAAIKLQEAGADFIVICTNTMHKVSDKIQESIHIPLL
                     HIADVTATVLREKEIKKVALLGTKYTMEQDFYKNVIINNGIEVLIPNEEDRIIVNDTI
                     FNELCLGIISESSKKAFLSIIDKLGKQGAEAVILGCTEIGLLIKQNDTSIPLFDTTVI
                     HAIEAALSSI"
     gene            complement(46866..48401)
                     /locus_tag="KNP36_003847"
     CDS             complement(46866..48401)
                     /locus_tag="KNP36_003847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875619.1"
                     /translation="MIFVKNKKYRKIAIIISIPILLVAQYYLFKFGILRPMVKGVEIE
                     IVDGEYVKDIDKYVVKLNETVTLSTGEYIKVPSYAKNPNIWFNVLDNSGTLKIDGNKM
                     TALKVGYSSVGIMKNSRVLKKATIKVVDPEVESLDMEINGDLKHVGDSATIESTIEVD
                     YDKFKKSYKPVYKSSNENILKIKGNKVSAVGVGKATIYAKCGNKEIERTFRIQARVAE
                     INMDDIKIEVDQNEKLKPDIITSPPGLEPPKIYYELVDSKLPVERAISLSSNGNVVGL
                     REGKDRVRITCGDKSKVITVTVVKETITNDYIQNLVGSHKIVNNKVIIKLEWDYMKDV
                     FDYDIYLKDKLSGESFKKIKSITINESDLGKSNKVYATIEVDMKGNQNIDFDIYVIGK
                     KDSDTTKPSNVINITNGNGNSNNDNNIKDMRVENISANVDRDNNVIRVNWSSISHKDC
                     TYSIYVKNNTNGDGEFTLYQSDIQGNEHTISIPEGDLNLDIYVVANYNGNSSQNSDVI
                     NVR"
     gene            48676..49725
                     /locus_tag="KNP36_003848"
     CDS             48676..49725
                     /locus_tag="KNP36_003848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HBF0875620.1"
                     /translation="MEINYKKRNFKSFAKRKNIEISVQRYLIDALSYMALGLFSSLLI
                     GTIFNTLGDNFNISLFTEVISPLAKQVTGPAIAVAIAYGLQAPPLVLFSCALVGACGN
                     ELGGPVGAFVATLFAVEVGKLVSKETKIDILVTPAVTILIGVLVAELIGPAVSAFMTS
                     FGNIIMQATTMQPIIMGALVSALVGIALTLPISSAAICMMLSLGGLAGGAATVGCCCQ
                     MVGFAVMSFRENGVGGLVAQGLGTSMLQVPNIIKNWKIWIPPTVASILLGPLSTTIFK
                     MENIPIGSGMGTCGLVGQFGTVTAMQSAGKGGISMWVGILLLNFILPAIVTLLISEFM
                     RKKGLIKPEDLKLDV"
     gene            complement(49774..50808)
                     /locus_tag="KNP36_003849"
     CDS             complement(49774..50808)
                     /locus_tag="KNP36_003849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875621.1"
                     /translation="MTGKIEEIKDKINRFCNSNLNQEYKDISFKILQNLLDNNKEIIH
                     SSRADIWSSAILNIVLEQNLLYNKKHPLHITKKEFSKQIGVSLNTINNKSSLIKDVCS
                     IDFLNQDTIAISNVEFWVKETNSKSKSVDLDLEKKKILYKRYIKLSQDANSDIESIRY
                     MEEAVNIGKSMITKEDKELGFWKGLSTRAYMIALESLARKLESINNLKESKKVLEYLI
                     EINPSDEQGIRYKLLNVLIRLNDRTSINKLFELYKEEKSATWMYSKALYYFKNKSMFL
                     ANDSIKVARSKNKYVGLYLLDWRNAFGREFVTEEEKAEAVYYYDENIVIWNEVKGSMD
                     WLLKKMLEFS"
     gene            complement(50826..51173)
                     /locus_tag="KNP36_003850"
     CDS             complement(50826..51173)
                     /locus_tag="KNP36_003850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003423269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HBF0875622.1"
                     /translation="MIRKKSELQVEVKENLNGGIGKVKLENIIQNEELKGKGRLFKRV
                     ALPVGSSIGVHDHTTDFEVYYILKGKGKVFDNGEFVEVNEGDVVYTADGEKHSIENIG
                     EEDLEFVALVLYM"
     gene            51431..52813
                     /locus_tag="KNP36_003851"
     CDS             51431..52813
                     /locus_tag="KNP36_003851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBF0875623.1"
                     /translation="MSVLKTQEKLKQPRDLYFCCSIFTFVGLAYYGMKLVLLLFLAEQ
                     VSKGGLGLTPAESASMLASFLAWTYFSPVIGGWVSDRFLGPKNCIILGMLMVSIGYFL
                     GYIANSKMDINIMIFLSGLGIGFYKGNLHTMVGNLYTNDDPRKDGAFSITYMATNLGT
                     LFGPLICGLVANEWFAMKSGLSISMYGYRYVFLFSSITVLIGLFFFIFGNRKFYKPLN
                     NDPINGRESIRKSLEYKKMLASRPLTLIEKKRIIVILVLAFFTVFFWIAYNQASMSIA
                     LYTKEHINLTVGNFQIPTSWIDSYNGLLCVILGPISALVWVKLSQTKKGDLSVPKKMS
                     LGFILLAIAFLFMIVAVIQTGTDPNSIHKASVFWVVGFLTFQSIGEICFSPVGYGMVN
                     KLSPEKYISFLMGVWFLGKFAANKLSGYTQAIIDQLGMLQVFIVIPSFLLIFGIILLI
                     MNKKLVELSN"
     gene            complement(52894..54687)
                     /locus_tag="KNP36_003852"
     CDS             complement(52894..54687)
                     /locus_tag="KNP36_003852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HBF0875624.1"
                     /translation="MNIKDRLSGLRKFMEEKNIDAYMIPSSDNHQSEYVGDYFKSREF
                     ISGFNGSAGTVIVTKDEAGLWTDGRYFIQAESQLEGSTIKLFKMGQEGCPTTDEYLYK
                     NIPEGGTLGFDGRVISAREGATLAEKLSKKGIKIEYQYDLIDSIWPDRPALSDSKAFL
                     LDVKYCGESFSSKLARLREKMSEKGTSTHVITTLDDIAWLFNIRGGDVKYNPVVLSYA
                     VITLKEVYLFVDESKLNEEILNELAKENVQIKPYNDVYEFVKNIDKTEKVLLDGTKLS
                     YTIYNNIPCEVEKVDEFNPVMFFKAQKNEVELENIRNSHVKDGVAFTKFMYWLKKNVG
                     KMEITEISATQKLEDLRREQEGFFEPSFNTIAAYKEHAAMMHYSATPESNYKLEAEGL
                     FLVDSGGQYYDGTTDITRTTVLGPISDELKLHFTSVARGMINLSKAKFLHGCRGYNLD
                     ILSRSCMWNMGIDYQCGTGHGIGFVLNVHEAPNGFRWRVVPERFDSAVLEEGMVTTNE
                     PGIYIEGSHGIRTENEIVVRKAEKNFYGQFMEFEVVTLAPIDLDGIAPELMNKDEKDY
                     LNWYHKLVYDKISPFLTDEEREWLKVYTRAI"
     gene            complement(54940..56331)
                     /locus_tag="KNP36_003853"
     CDS             complement(54940..56331)
                     /locus_tag="KNP36_003853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide MFS transporter"
                     /protein_id="HBF0875625.1"
                     /translation="MSSTESVSKKSGHPKSFWLICMTILWERFSYYGLTALLVLFFTA
                     SVAQGGLGLSTQEATSMFGLFTGLIYLTPLVGGWLADKVLGQQKCISIGALLIAIGDF
                     VLFASSTSIAMVWVGLSIIILGNGFFKSSCSNIVGDIYPKTDVSRKDAAYSLFYMAVN
                     VGAFIAPIICGLLSDNVFAVRGASGDIVSYGYKMAFLICGIGMMLGMIIFTLLAPKLL
                     NEVGKYPVTKGNKGEKIEYGPLTKLEKNRIIAMVILFLFVVLFWTAYYQTQSSFMIYV
                     RDNVNRTLFGFEMPVAWLTSLNAILCVALCPVLATLWVKLSHTKRGDFSIPVKMGLGM
                     IIMGVGFIVMVFATLANGPDGMVKASILFIVLTYIFTTVGELFLSPIGLAMFNKLAPA
                     KYATLSMGAWYLTSFFASLLSGKIAGFTATLGFLQIFGGIATVLIIFGLILLGIRNVL
                     TRLMAMDLLTKEK"
     gene            complement(56785..57927)
                     /locus_tag="KNP36_003854"
     CDS             complement(56785..57927)
                     /locus_tag="KNP36_003854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003440250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HBF0875626.1"
                     /translation="MSEEKNPKENTLDESKNSDNVNSKKDDVSDEKNTDNKVKKREIK
                     LNNKTLKAIVAIVAVGAICLGGGYVFGKEAGRKLPATSKHYNSSEVVATIGDKKITGE
                     MLRKRMEPLFYLNAKTTMTDDEIRSYESNMIETMITSDILSSEAAKEKISITNDQLDA
                     QYNNLMSSIESAMGMTKEEFLKQFDLTEKYIKDDMKKELVASKYLNEKSKVTDKEAEN
                     YYNKNKSNYLQVRASHILIKTVDDKGKQVSSSKKAELKKEAEEILKKAQAGEDFATLA
                     KKYSEDSSAESGGDLGFFGKGQMVESFEKAAFALKKGEVSNKLVESDYGYHIIKKTDE
                     KYQPFEEVKSDLVSSLTSEKQNLLIQNLKEKYNVKITDKYQMKAKE"
     gene            complement(58038..59075)
                     /locus_tag="KNP36_003855"
     CDS             complement(58038..59075)
                     /locus_tag="KNP36_003855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003430405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HBF0875627.1"
                     /translation="MLKKWFGIVKKRQKSESVKEEGEVILKNEKILSEEKLIDEEGVV
                     VNIDNQILTKVVNDDNEIEEKIIEEDLLISENTIKLDDKEAIINDKNIELCKKEVQVE
                     SEKIGLNKFEGLDQNENYNLEKNVIEEKKVSECLTEEDLEYIKEIKIKRGKSIKAINL
                     YTKEEWVFDTHIQCSKKLKVPLGYIRENLKYGYMDYFGDAINYLSEVLNIDEYCKSEW
                     SYLDNSKSPSEIFNILNNKIFSIRLSNEKRNEILTNDKIEALKMNYRFECIDEEYDEY
                     FKKYKSIIKRGGKKKVELVNKKGDILEIFKSLEECAIYLQKEKNEVIQMLKYGDTKVG
                     RNFIRYSLRSI"
BASE COUNT        19799 a         9903 c         6919 g        22956 t
ORIGIN      
        1 attaaactca aaagtcttat tgaaaaattt tctattcaca taaattgttc aatatataaa
       61 atagaaaatt tttttaattt tcaaaatata ttctacatat ctaatatgta attacaataa
      121 aaaatgctat aattaacata ttattaattc gttttattat tgtagtatgg ctatgaaatt
      181 atgaaaatat ttctctaatt aaaaatatga tttatccata tttgtttatt gtagatacag
      241 actatacaaa aataaatagc acttatttca gtataaaaac atatatagtc tatatttaga
      301 ctaaaaaagt ataaatagtc tatataaaac aacttaaact atgaatataa tctaaagtgg
      361 agggataata attggcaaat ataggaaaaa taataggaga tagaataaaa gtctatagaa
      421 caaaattggg atatagtcaa gagtttctag cagaaaaggc aggtttacat ccaacatata
      481 ttggtcagat tgaaagagct gagacaaata catctatcaa tattataatg aaaattgcta
      541 ctgctttaga cataccactt gaattgttat ttgcaaatat tattacaaca gaaggcgttg
      601 ataactctgt acctttagaa tgttatgaaa tgattaataa attaactgaa aaagaacaaa
      661 ttgcaatgct agagttaata aagtgcatca ttaaatacaa agaaatataa gtgagggaaa
      721 tagtaacaat aatgaattat ataggtaaaa gacttaaaga agaacggaaa aaagcaaatt
      781 taacttcaaa agaatttgca aatatggttg gagtatcgcc ttggtatata actcaaatcg
      841 aaagtggtaa aaagaatcca agtcttaaaa cattcataaa atttgtaaat atattaaata
      901 tttctgcaga tgttcttata aaagatatta cttccactgg aaaaacatat ttagaaaatg
      961 atataaatga agagttaaaa gacttaaatt caagagaact aaatctgata tcacagatta
     1021 tagacatcat aaaaaagaat aaaatataat tctttatatt ttatataaaa aaaaaggtta
     1081 tttgaaataa ataacctttt tttgtctttt tgtgttaaca ttgtcttata gtgctaatga
     1141 gtactattag accatgttct atggccttat tttaatataa aacgattgga gataggctat
     1201 gattgtgatt gaaggtagcg ataaatttaa gattgcaaaa gaatatattg atgtagaata
     1261 tactcttttt agcaaagtaa cttttaggta tgaaaagttg aaatttaaag ataatgctga
     1321 attggaaaaa attaagatgt ttaaatataa aaatggctac atccctaata aattaaacct
     1381 ttcttttgga tatggattct cttcttataa aaagcaaata attagagaaa ctgtagatac
     1441 tttaagattg acagaaattt tttcaagcga gaacatagaa gatattaaat ttataaaaga
     1501 tggtacaaaa aaattagaaa ttagcataga gaaagttgtg aaatttaaac gtcgaaaaaa
     1561 aagaaattat gtttgttgct attgccctga tatgtataga gacataaaac tcgacaaaga
     1621 atctatcaat aagatataca acagaaaaat aaaaatagaa agagaagtta atatttttga
     1681 agatgaggat gttataataa acaagaaagt attgaagttt ccaaagtctt ggacaaagaa
     1741 tatgcaaaaa tattggttaa gtgaaaataa gtatcccata cattctactg taattgatga
     1801 tgatagatat aaatgttgta atgtacaata tacaaaaaat agagtgataa tattatatta
     1861 catatataac cattaatata cataattaca aaaaaataat gacaaatata cataatacaa
     1921 atatatcttc tactttagat aaaacagtta ttatgaaaac ttactatcta taaataatag
     1981 aaatgctagt ataccatcta taatctaatg tctagtaggt tttaatggca tattttaaat
     2041 atgccatagt tgatttataa gattttctat atcactttca aaatacacac taaatagttg
     2101 cttttcagat ataattgccc aatttaaatt ttactatctg aaaagttttt tatatttaat
     2161 ttatatcttc aaaaataccg tctaatattt ctatataatt aatttaatta atactcttat
     2221 gtaatagatt aagtactgaa tttaactctt taaatgatat ttgccctggt gctgaaacac
     2281 tttttgcagc tccaaaagtc aatgcagaac caaatatttc accacacaat ctacttataa
     2341 cacccattcc tgacattgac attgttatta ttggtctatc tgcataaatt ttaaacattt
     2401 catttgtagc ttcaagtagc actaacacat ctttttcatt ttgcggcata acagctattt
     2461 tgggtaaatc tgcgcccaat tcctgcattc tacataaacg agatacaatc tcttcttttt
     2521 ttggagtttt attaaaatca tgattagata taattacttt cacttctttt ttatgagcaa
     2581 aattaactac ttcatctatg acctcatctc ccataaataa ctctacatct attaaatcta
     2641 ctaaacctgt attagaaatt tctttattca aagtagtata ataatctctt gatattaatt
     2701 tttctccccc ttctactaca cttctaaatg tgaataataa agggatatca tgtatataac
     2761 ttcttaattc atagagaact tccttaactt ctttaatatt ttctacattc tcaaaaaaat
     2821 caactcgcca ctctataata tccaaacatg catcttttaa ctctttagcc tcttttataa
     2881 tatctttttt atttttccca ataattggta cacaaatttt aggtctacct tctccaatag
     2941 taatattttt tacttgaact tttcttttca tattctcctc cataatcaga aattctatag
     3001 gactttaaat tctattttct gcacaattta attatacatt aaaaatacta tacattataa
     3061 aaatactaat ttaaaaataa tttttattct aattcttaaa acaatcccac atattttaga
     3121 aaaggtactc tataatatac aaacacttct tttttaccta aatttatttt aacatcctat
     3181 aattttcaca atattcttta aattttactc atataaacaa tattattctg gatgctaata
     3241 gaattaatct ataaatcata gtataattat gcagaaataa ctcgaatttc actacttatg
     3301 aagagattga atattaatga atctaaatca tttgcattac ttaagagttt tgactaaagt
     3361 tgaacaccat acaaaagtag ctactcaatt gtttataccc caaccaagct taagtaatgt
     3421 tatatagatt ctcgaaaaag aatttggtat ctttttattt gaaaaactta tattaaattt
     3481 gattatcttt tcataagttg gtaaatgtcg atatatcctg tatctacaag gagtatcggc
     3541 attttctttt tggaagatac tttgcataag ttggcattta accgtataag aatgccatca
     3601 aaagtagtaa ataagtagta aactctagtc atactactag gattataacc gttccatttc
     3661 agctctcgaa gaactaaatg aaccatgtgc ataatagcca agcgtcatag taatgttttt
     3721 atgccccata atatattgca atatattagg actcattcct ttgttagcca tatttgtaca
     3781 gagtgtatgc ctaaaggtat gtggcgtaat ctttggtagc ttgtcctcat gggtcttatt
     3841 atacttcttg actaacgctc ttaacatgct ttgataatga gttgcttgtt ttggtaatcc
     3901 atcttgttta agaaatagga agttctggta accatcaaca atgattggtt ctgctttagc
     3961 gttcttacgc cgttccacga tacgttcaaa tgattgataa gctctttcag tcattggaat
     4021 ttctcgctta ccctgtgtgg tctttggaac ttctacataa tagccaatct tagtatcact
     4081 caacaattga tggtctacca taatggcttt atttttcata tccaattcta aagtcaaacc
     4141 gcataattca gaaatgcgta gtcctgtttc taagaggata acaacatcat cataatattt
     4201 acaataagtc ttatcgctcc ccataaagga taataagccc atttcctgtt ctggtgttag
     4261 agcgattttt ggttctgttg tatcttccaa aacatcactt aactaaaaat taaatggatt
     4321 ctttctaata cagtcgtctt gaattgccat gaaaaacgac gctttcagtg agcgcttata
     4381 attgtcaatg gatttataag cacacccatc ttcactcatt cggatagccc agcttttagc
     4441 gtctgataat ttaaccatat caatgctttt tgcacctagt gggtcattga tagtatctat
     4501 attttgattt ataatttata cattttttta aaaacagact tttaactgta aagaatctat
     4561 gtataaactt agctatgttg tccgtgtatc tacaaagaat cttgacgagc taaaaaggcg
     4621 ttgtgatgaa gtcaaagact tttacgacga cttatcaatc aagctcgtgc gtccctttgg
     4681 ggatatgttg ggattgcatg gcgaatttat tcctgtcagc aaacgttaca tcaatgatta
     4741 tattcaatat gtcacttcgg attttttggc tggacttggt tttggagcga cacaaaccct
     4801 tggcgaacat gaggatatct atcttggcta caatctggac actggaaaga atgtctatct
     4861 aaaacctgcc cttgctagtc aaggggtaaa gggttctatt accaatgcgt tagcgtctgc
     4921 gtttatcggt tcattgggtg gtggtaaatt attcagtaac aatatgcttg tttactatgc
     4981 ggtactattc ggcggacagg cggtcatagt tgaccctaaa gcagaacgcg gcaaatggaa
     5041 agaaacgcta ccagaaatag cccatgagat aaacattgtc aatttaacca gtaatgatga
     5101 aaacaaagga ttgcttgacc cttacgtcat tttgagccgt aaaaaggatt ctgaaagttt
     5161 agcgattgat atcctaacat tccttactgg tatctccagt cgtgacagtg ataagttttt
     5221 gcagaaaaat gacaactgga aaataataat ggaatagttt ctatgtaaat atatttttac
     5281 tatcttacct aactaattga aagatgatat aatttaatca aagatttggt aaggagggat
     5341 gaatatgcat ttaattgatt ttatgaatga agatattaaa aagaagcttg ttaaaaaaac
     5401 gtataaaaag aaagagacta ttctttttgc tgagcaagaa aatgaatatg taattcttat
     5461 gattgacggt attgcagaag cattcatctt aaatgtgaaa ggaaacatct caacgattca
     5521 tctttataga agtggtagtt tttttggaga aatggaacaa tttaatgatg ggaaaaaacc
     5581 cgttgaaatt gtcgctttca cagattgtaa tgtatataaa cttcatagag atgatttttt
     5641 aaactggtta aggggagatt ttgaagctac aaaatttctg attcgagaaa tatctagtaa
     5701 attagttgta aatgctgaat taattgaaga attatcatct ttaagtgtta aagaacgact
     5761 tctgaggtgt atatccttac actattatag aagtgaatta aatctgctta ccaaaaaaca
     5821 gcttgctagc gaagtaaacg ctccaattag aagcattaat cgtgctataa atgaatgtgt
     5881 acaagaacat ctaattgctt atgaaaacaa aagatttagt gtaattaatc agcgagaggt
     5941 attaaagaat cttcctacaa cataagtata atttcaaaaa agtattgaat aataattatt
     6001 caatgctttt ttatttcggg tcaagtgacc tatttttttt tatttcttca ttatataata
     6061 ctcctatgca taattatgtt ggattgatag ctaataaaag acagtgagag gtgttatatt
     6121 atgactaaaa cacaacagaa aatgatacaa aacgtattag aattttcaaa aagagatagt
     6181 aggataatag gacttgcaat tagcagttct tatatcacaa aatcgttaga tgaatattct
     6241 gatttggatt ttctgattgt agcagatgat aaatcctatg aagaagttat cgaagagaga
     6301 ttacttattg tggaacagtt tggaacatta gtttctgctt ttactggcga acacgttgga
     6361 gaacctcgat tgataatttc cctctatgat tcccctgttc ttcatgttga ttttaagttt
     6421 acaaccttag atggtttact agatagggtt gaagattcag ctattctcta tgaagaaaac
     6481 aactgcataa cagaaattta ttctaaaaaa gaagcatact tcccaactcc agacttacag
     6541 tggattgaag atagattttg gatttgggtt cattacgctt gcactaagat tggacgtaga
     6601 gaactatttg aaacaattga ttttttatct tttttaagac aatcagtact tgccccatta
     6661 atacagcttc tcttaggtaa attacctcgt ggagttagaa aaattgaatt ggacgcaccc
     6721 caatatattg aagcattaga aaagacggtt gctaaccatg aatataaaag ctgtgttaat
     6781 gcattgcagg ctactatcaa cctgtatctt gagttaagag aggaattatc acaaagtcct
     6841 attgtccgaa aggttgaagc tgaaagggtt gcattacagt attttcaaga tttaatcaaa
     6901 taaacccaaa gtaaaaaaat attgaatagt aaatattcag tgttttttca tttttggtca
     6961 aatgacctag attagttgtt gtaacaattc tataattatt ttgaaagtaa cagtatggag
     7021 gataactatg agtgatattt taagtagaat tacaaataaa attggggata agaatatagt
     7081 tgataagtta tcagctctat caaaatcaga tttgaactca cttctattag aagtgtttga
     7141 tagacaagca aatactttaa ctgcaactga tattctaaag tcataccaac taaatagatt
     7201 tactatccct agcggtatag atccagaaga aattcatgct ttggaatcaa aattattgag
     7261 aaaagcattc aatatggata tcaagacgat tatgctttct ccctctgccc cattaggtag
     7321 ctgtagcgtt tttggctccg tagatcaata taacgtagta agtgctctac gagggacaga
     7381 aacacttgca gacccctcaa atatgttggc aataattatt gctgataaat taaaaagaaa
     7441 agaagaaaat aataccatac ctatccacat ggctactact gctagggtaa taagagcaca
     7501 aaattttgta ggtaaaggtt tatattcaca ttttggctta tattgtatgg tttcatctgg
     7561 tatagataca gggtcttaca cttgtgaaaa aatgttgtta gaaaagcact taaactatta
     7621 taaagatata ttaagtgaaa tagaaaatgt tcgtttctct attattctac gcaaaagaaa
     7681 cggatacaaa gataatgacg gatttttcga cagaatggtt gaaactatca aacttatttt
     7741 tcctaatata gagttatcaa ttcataatga tgatgttgat aataattatt ataaaggtat
     7801 caatttcaaa ttatcggtca aacaaggaaa tgaaaccgtt gaaatagttg acggtggatt
     7861 tgttgactgg acttatcaaa tgcttggaaa taaaagagaa cgctgtttga taagtggtat
     7921 tggcttagaa agatttcttg tagctgtttc ataaaaggag aagaaaaatg gaacttatag
     7981 agtggaatta tgcttatatt accgatttag ttgagtttgc gaatgataaa gaaattgcaa
     8041 agaatcttcg tgacaacttc ccccaccctt atagggagca aaacgctaga gattttgtta
     8101 gtttttgttt ggcaacttca gatgttaaac aacttagcta tgctattttt tatcaagaaa
     8161 gggctattgg aagtatcagc ctaacatttg aagaagatac ctctattaat aaaaatgctg
     8221 aattaggtta ctggcttgct aggaactatt gaggcaaagg gatagcaaca aatgcagtaa
     8281 aagaaatatg caaaattgcc tttgaaaaat acaaccttaa caaaattcat gctaatgtat
     8341 attcctacaa tagagagtca agtaaagtat tggaaaaatg tggctttaag attgaagaat
     8401 actgtcacaa ttcataataa agaatagaaa catgattgat tgccatgtat atagtttaat
     8461 tcgaccgcaa tagcatttat tagaattaac ctacttttta ataacagaat aagtttttcc
     8521 cctctattaa tttcttatgc atctttgtat ttttatgaaa agctagccaa tgcatatttc
     8581 catacatcaa tatggtggtg gcttacaacc aatataaatt aaatacgttt taaagaatac
     8641 acatttttgc cctataggca gagtgtgtat ttttttctct tttttttgaa atttatcgaa
     8701 gatttaacgc cctcccaccg tgataggagt aagcaaggtt atttaactcc ttgcgatgga
     8761 aagagggtga aatcttatgg ttgatgaaaa gacaattgaa catcaattcg acagtttctg
     8821 taaaacagtt ttgcgtaact atgctagaga tatttatgac gaaaataaac gcagaaatga
     8881 ttatttggta tctctcgaat ctttgtcact tgcagaatta agtaaattga gtattttaga
     8941 tgattatgat tctaactaca tctgtatggt ttcttacgac tacaacatac gaattgaaga
     9001 tgtattaatg gcgcaagcaa tcggaaaact tacaaaaaga aaacaagata taattctact
     9061 ttcattcttt ttcaacatga caaatgctga catagcaaca ttgatggatt tagcagaaaa
     9121 taccatacat tatcacaaaa caaatgcact aaaagagttg aaagaactca tgcaggaaca
     9181 ttgaaatgaa acctactaaa gaagtattac cttttacaat tattttactt gctgtacatg
     9241 gcgatgtaaa tgcaataaac gtaatactta aacattttga acactatatc attcgtcttt
     9301 cacagaaaac tttatttgat gaatacggaa atccctatat tcatgtagaa gaagaaacaa
     9361 agcgaatgct aggaacaaaa ctaatcactg ctattttgag atttaatttg tcttaatctc
     9421 gccctctctc catgtatcaa gctatttggt acatggagaa tcactaatta tttgtctata
     9481 aaagcccaca agctattgtg attttttata ggcaaatcaa tgccgactgt tctttgacaa
     9541 ctgaataaag tagatagata cgtttgtgat acagatagcc aacaaatact atacgccatg
     9601 accttaatca agagagctac tatatagtga tttgtgaata acctttggaa cggttgtttt
     9661 gccgtaacct gtaccacagt ataatgatac acctgtatga cacggttctg tccataagaa
     9721 tgggattggt tgaaatacca atggagctta tcaaagccat ctatctactt ctgaactacg
     9781 aacatagaaa ggagtgatac attatatgaa caatactgat gtacctattt gggaaaaata
     9841 taccttgacg attgaagaag cgtcaaaata ctttcgtatt ggagagaaaa aattacgtaa
     9901 acgtgctgat gaaaaccttg attctggctg ggtcattatg aatagcaatc gcattcaaat
     9961 aaagagaaaa caatttgaga aaatcgttga tacacttgac gttatctaat gaaattgagc
    10021 cttatatgtt ataatattca tatgacgtat caagctcaat tcggttattg agaggagctt
    10081 cttatcatgt caactgaaaa aagacgagat aataaagata gaattttaag aactggagag
    10141 agccagagaa aagatggaag atacgcatat aagtatgtat attcatttgg taaaccacaa
    10201 tttgtttact cttggaaact tgtacctact gataaacccc caaagggaaa acgtgatgat
    10261 atatcattaa gggataagga aaaagcaata caaaatgacc ttgatgatag cattgacact
    10321 attggtaaga aaatgacagt ttgtcagtta tacgctaaaa agaatggact aagaaagaat
    10381 atccgactta acactaaaaa aggacgccat tatcttatga agattcttaa caaggagtga
    10441 ttctgtgaag agatgtattg tagtagtgga atagtcaaaa acataatata tattaaagga
    10501 gagatttaaa tatgactatt ccaagttcaa ataaggtata tccaagaagt aatgattatc
    10561 aaactgtata tcttaaaaat gtaataacaa gggaaaatat agaagttgga gattacacaa
    10621 tatataatga cttttataat gacccaagag attttgagaa aaacaatgta ttgtatcatt
    10681 accctataaa caatgataaa ttaataattg gtaagttttg ctcaatagca tgtaatgcaa
    10741 aatttctaat gactagtgga aatcactcaa tgaaatcaaa atccacatat acttttccca
    10801 tcttttatga agaatggaaa ctcgatatca accatataac ggacgcttgg gacaataagg
    10861 gtaacattat aattggaaat gatgtgtgga taggttatga ttctataatt atgtcaggtg
    10921 taaatattgg tgatggtgca attattggaa caagagcagt agttactaat gacgttccac
    10981 cgtattctat tgttggagga gtacctgcaa aaattataaa aaagagattt aataatgata
    11041 caatttcaaa attattagaa attaaatggt gggattggcc atataaaaaa attcaatcaa
    11101 acattaagca tattcaatca ggaaatattg ataaattagt ttaatatttt ataatttatt
    11161 tatattaaac tttactttaa taatcatttt ataagagctt tttcaaaatt tgtatattat
    11221 tttaatatat ataaatttaa tacaacatta aataaaataa aaagtaaagt tacttaataa
    11281 aaagttactt tactttttat tatttaaatt cctgttttta ttataatagg taaaattcta
    11341 ttaaactagt tcacattttc attattattg atatattata tatgaatata ccattttgtt
    11401 ttttaataaa aaatcatgct acatcaatag taagcaacta ttaatgtagc atgatttttt
    11461 gtatctaaat aatcttagta tttacctatc agtatagatt gatatatcaa aaactatagt
    11521 cttctatatt cttctctttt tagcttttgg ttacttagat agtaatcaat ttcatcaatt
    11581 agacgttgtt tatcatcagg taatacacct tttaaattag cataatttga tgcatgatta
    11641 cttctaaata caattttttc attagcatct atattcttta tcatctcttt aatttcttgt
    11701 aacacagcct tatcctctag tattgtaaac tctcctgcct taagtaaatc gtaaagttca
    11761 gtattaggtt ctaccattaa actaagtaca cccacataat ctggtgaaat tgctcctagc
    11821 atttttcctg tatcaactgc atgctgatgt gtttttttag ttcctccaag acctgctatt
    11881 acagtggctg ataatttaat cccacttttt ttaacttttc taccaacttt tattaattgt
    11941 tcactactaa aacctttctt aatatcttct aatacttcat tgcttccact ttcaagccct
    12001 agataaatca ttttaacacc aagttttctt aattctttaa gttcatcatc agattttttc
    12061 tctatagatt taggagagcc gtacatagta attctttcac actctggaaa aacttctttt
    12121 atatataaaa taatatctct taatttctcc attggtatta tcaatgcatc tccatctgct
    12181 aagaatattc tttctacatg cttataatat cttctaaata tatcaatttc attttttatt
    12241 acttctagtg gctttatttt aaatttttta gatttgtaca tactacaaaa cgtacatttg
    12301 ttatgagaac atcctagtgt gacttgtatt ataagactat aagcctcact tggtggtctg
    12361 taaagtggca tatcgtattc catattaaaa tcccccttgt aataaaatat tcattctatt
    12421 atattattaa tatttacttt aaataataac ttataaaatt atatttttta aattttagtt
    12481 taagatatat tctttaaaaa tttaatgata ctattggcag taatattaag ttgtttttct
    12541 tgacttataa tagcatcatt atctcccttt tgttttccat aatctccaaa ttgtgcatga
    12601 tttcctcctt caatctcaac ataagttgta tcatcaggaa gtttttgttt tgattctaca
    12661 agacttttaa aattgactac tccatctttg ctcccccata tagatataac tttttttcct
    12721 aattctttca actcatcacc cattggataa gaagctaaaa atacaacgcc ttcaattaat
    12781 ttattatcac gtgcaaaatt tgatgctgca actcctccta atgaatgacc tcctattacc
    12841 caatgttcta tgttgttgta agaatccata actttctgtg ccttattagt tccaagtata
    12901 gctagattaa gtggcatctt tacgattaca acttcatatc cactttctgc tatttttctt
    12961 gcaagtggag cataagattc tatttctact ttagctcctg gatacaaaat taaaccttta
    13021 gaaacttttc ttccttttgg tgtaaatgaa atgttttcat ttacagttac ttcaacttta
    13081 ctattgctga ctagagcttc ttttgccagc ttttgaggtt catatgtttt atttatccat
    13141 atgaaaaagc caagcaaaat caatacaaat agtataccta ttcccttaaa tatcttattc
    13201 tttatgttaa attttctatt attattttta tcatctttgt tctcaacctc atcataaagt
    13261 aaaggtctct caagttccat agttatacta aatgtatcat atttcttatt acgctttacc
    13321 tttacatctt tactcataaa tctaaccccc ataatatttg aatactatta tagtttatcc
    13381 taagtaaatt gttttttcaa ccaatgaaaa aaatcaatat tttaactatt ttcatataaa
    13441 attcataaat atatgttttt tgttttttat atattatttt cttttagtat tttataaaac
    13501 aaatagccat atactttatt ttaaatatat ggctattcta taatttaata tctaagctgc
    13561 ttcttttatt gaaactttag ttatattact tattctatac atttctttga caccatttag
    13621 agtttgcagt aagtttagac atattatctt gtcacctaga cttttagtat ttataatact
    13681 ctctaaaatt acacttcttc cttcatcata cttatctaca ttgtaatttg aaatataatt
    13741 agtatctctc aatatttttt caacatcttc atcttttatt ttatttttat taacatttat
    13801 atatagatta tacatattac ttattagtaa tttctgattt tctaaaaaat cctcttgatg
    13861 tttatcttta tatatagcat ttatcaacat aagtctatct tcaataagtg atggtatcaa
    13921 taataaattt tttatatagt aaacatcagc tacattttct atagacttat tgacttcatc
    13981 aattatattt ttaactattc ctttatacat ttctataaca tgttgatagc ctgttttagc
    14041 atcatatggt aatataaact tatttactat taatgcaata attgctccta atgctacata
    14101 tgaaatcctg cttatggtta aaacatttgg gtctcccata actactgctg aaccaagagc
    14161 tgaaacagtt acacatacca ttaattttct ataatcaact acataagagt ttatataccc
    14221 tgctaaaaga actattaacg accttaatgt actatctttt attattgaaa ataatacaat
    14281 aaatattaca gctcctataa atgtaccttc tattcttttt ctagaccttt gtatacaatt
    14341 ttctgcgtaa ggttgtgtta atgaaaagac agttaacatt atccatcttc catctcttaa
    14401 atggaaataa tccataataa aacccgctac agctgtagct aaagcaatct ttactgcata
    14461 agaaaatctt atagaattta aattaaagtt tttcttatat attgatagtc gtttaaattc
    14521 atgaggtatc tttgattttc tttcagcttt cttttcgtct cttgatttta cttttttata
    14581 atctactaaa aactcatata aattttctaa aacactataa atttctttta aatttatatt
    14641 tttagtatcc tgagcaataa cataatctct aaatcctaat atctctttat cagttatggt
    14701 atctttattt tctaaacaca tcttaatata gtttatttct ttcgttgcta caactagaac
    14761 atctgattta ctatttatgc tactttcttc taaaatattt tttatatctt catcttcaaa
    14821 ttctttacta tcctttttgt atctttctag gattaaactt attctttcta atgaaaataa
    14881 aatattcatt atgtctatac ctctaatact gatataaaag tcatcttttc tattatcaaa
    14941 aataaccatt ttcaaatttt tagatataga atttattcta taattacagc tatctatttt
    15001 tctcatacta gatttaatta tagaactatc atcattaata gtatttttta aaagactaat
    15061 tttttctaat aattcatcac atatagatat cagttcttta tctccgacat ttttcatcct
    15121 atttctattc ataacaaatt gagcaatcat tattataact gctccaacag ctaaagccga
    15181 caatctcata ggaaattcac tttttcctac aggtatactt accataaata tatacattag
    15241 accaaagggt acatatactg ctctttttaa gtcataacta aatacatacc ctattataaa
    15301 taatgctata aaatttaata aaactcctaa atacatattt tgtactgcaa aaaatgatag
    15361 tattcctaag attatattta ttgctaaata cttcagtaaa tttttaattg gagaaatagt
    15421 taaatctctt tccaagagcg ttagcatagc tgttactata cctacaccta taagtgtatt
    15481 tttacttcca aataaatata taaatataga aataaatgct attataaaaa taaacaactt
    15541 tgtttttgat attactagtt tctttgtcat catatccccc ctaaaaattt caacaagacc
    15601 aattttatca tatttgttat cttattcaaa atgcgctttt ttacggtagg actttaactt
    15661 tttttatatt tagaactata taattcatat ataaacgtat tttttatata tataaccgat
    15721 atattttcgt atgctcccat attttttttg tttcaaatat tttttcaaaa atataaaaat
    15781 aactctctca acaatactaa aaatgcattt atcaagagag ttataattta tacaataaat
    15841 ttaattaagc ttttctttac ctaatatata agttccaaga cccataaata aagctcctcc
    15901 aacaatattt ccaagtgtta cagctactaa attataaata gctcctccaa tagtaactgt
    15961 atttattgtt ggtgaaaata atgaaacact ataaattgtc atatttgcta cactatgctc
    16021 aaagcctgat gttataaaag caaataaaca taagaatatc ataattattt ttgcagtatc
    16081 actattagtt ctaaacgaac acaacactga tacacatact agaatattac ataaaatccc
    16141 tctaaagaaa agagctgtaa atggcatgga tgctttacta gctgctgtat ttgcaaaaaa
    16201 ttcagctaca ggtcctttgt ctattagacc agttcctaca aatataatgc ctaaaaccaa
    16261 agctccgatt aaattaccta cccaactgta tgcccatatt ttagaagtat cttttatact
    16321 tacaccttta tttaacatac cagcagacat aaccatattg tttccagtaa ataactctgt
    16381 tcccgtcatt ataaccaaac ttagtgctat tgcaaatgat aaccccatta ctatcttagt
    16441 cataggtgaa cctgcatcag tcaaaagtcc tccaatagta aatatcaaaa gtatacctat
    16501 acctacataa agtcctgcaa acgcagaaga taccaaatat tttactttac ttgtgtttaa
    16561 taaatttatc ttatttatag ctgcattagt taatttatcc aaagtttctt tatgcataat
    16621 tccctcttcc ttctattaaa ttttaattta ttcaaatata tgttttactc aatttataga
    16681 tatttaattc cactccagta tatgttttcg tacattttag ttatttctgg aagctctaca
    16741 ccttcaagtg cccatttttt aaattccata aatcctgttc tatcaattat atatcctata
    16801 tgttcttttc ctcctggtgc atctttatct atatactttt ctacatatct ataagtatta
    16861 agtattatct ttattatgct gtcctcatct acccataaaa gaaaatcttc tgctagtcta
    16921 gggtttttct ttcctgttct acccattata gctaatctat agtatttttt ctcatctcta
    16981 gtccatgcat ttgttgggca atttagcaca cactctccac agcctataca cttatcttta
    17041 tctcttacca ccttattatt ttctgttttt aatgctccaa cagatatctt agaacatttt
    17101 tttacacatg ctccacaatt tacacatcta tccttttcat atattggtaa agccatacca
    17161 ataattccaa agtcattcat tctagctttt atacaatcat ttggacaacc agttaaagcc
    17221 actttaaaat gtaaatcatt tggaaatata gctttttcta ttcttttagc aaattcagtt
    17281 gtattatatt gagcctttgg acagacttta tttcctatac aagctgctat atttcttgta
    17341 cctgctgctg gataacctgc gtttttctca ctttgattta tattcatttt ttcaataaca
    17401 ggttgtataa ttttatttat ttcttccata tcttccatat ttattcctaa tatttcaaac
    17461 ccctgtcttg tagttatgtg cacctgtcca ttgccgtact cacttgcaat tttagaaact
    17521 acagctaaac tctcagggtc aataagacct ccaggtactc taactcttaa agaagtctca
    17581 tattttgttt ttgtaattct ataagcattt ttcattactt ttttggtatt taaatctctt
    17641 atcacaaact tcacccccta atcaataaga tttttagcat atgaataatc aaatactggt
    17701 ccatctaaac atatgtaagt atcatccatt ttacaatgtc cacatttacc tattccacaa
    17761 cacatttttc tttcataaga aacccaaatg ttcttttcat ctaaatctct ttttaaaaat
    17821 tcttctactg taaatttcat catcattgga ggtccaacta caactataga agtattgttt
    17881 atatctttca tatccaattc tggtatgtat tttgttacta atcctacatt accactatat
    17941 ccttcctctg ctccatctac agtaactaaa atatcaagtt ttttactcca tctctttaaa
    18001 tcatctgcaa ataaaatatc ttttggtgat ttaaatccta ctattaattt aaacttttcg
    18061 catttttctt tattattata aaaatattca actattcctc ttacaggggc taatgcactt
    18121 cctcctgcca ctactacaat ttctcttcct tcataaaggg atacatcaaa tccatttcca
    18181 taaggacctc ttataaaaaa agaatctcct tctttataat taaacaactc gctagttact
    18241 tttcctacat ttcttattgt aaagtcaata taatcctctc catatcctga tactgatatt
    18301 ggactttcac cgtatttagg tatagatatc tcataaaact ttccaggcaa tacacctttt
    18361 gtattgcagt ttactctaaa agtccattct ttatcagtat gtttaactat atctagtatt
    18421 tttgcactta ctggtatata tgggttcatt tatacttcct ccttactaat tactaaatca
    18481 tttatttttt ctatacactt tgaaaatgat atgtattgcg gacaggcatc atcacatctt
    18541 ccacagccaa cacacatatg atatccgaat ctttttttaa aatcatgtat tttatgcata
    18601 gttttaaatc tcattctttc gccttgtttt tttctaaaag aatttccacc tgctatatct
    18661 gtatatccat ctacttgaca agaagcccaa acccttcttc tctcacctac attttcgttt
    18721 tccttataga aaatatcctg cattgtaaaa catgaacatg ttggacatac aaaattacat
    18781 ctaccacatc ctatacatct tgtatcatat tcatcccata ttgaatttcc tatcatttca
    18841 tttgaatcaa tattctctgg cacatctaca gatattaaat tatcagttac ataatcaaca
    18901 ttaaattcag ttgcttctcc attaaatact tcaaattcac tatcctttat atctaagtac
    18961 agtgtatctc cttctatatt taatccaatt gaataattat cagttttgtt agaatccatg
    19021 ctcacacaaa aacagtttct aaaactttcc ttacacccta caagtgcaaa ctttacttta
    19081 tctctgatat ttttataaaa ataatctttt tcttcaccat tatttagata tatttcatca
    19141 agtcttttta taccatttat gtcacaagct cttaagaaaa ttaaaatttt cttgttgtct
    19201 aaatcgcttt ccttaaactc tttttcagta aaataaaaca atacttgatt tatgggaagt
    19261 acaacttctt ttggtgaaaa gtttgctttc ttagcaaatt ccatttcttc aaaagcgttt
    19321 acctccttgt atcttataac atcagtatct gaaaaagtac ctttaaatgg gattaaaact
    19381 ggtgcaaata tcttgtagtc tttttttaga taattcagac cttcattgaa cttagatgaa
    19441 tctaatttta gtttcatttt tatcaccttt cttatatttt agttttactt acttgctatc
    19501 ttgtttaaat cttaacactt tattttctat gcttccgtga taattatcac agtttcaaaa
    19561 ataataaaaa aaatattaat ggagtttatt aagttctgtt aatatttttt tattatctac
    19621 attattcgat ttcaaatcta atcacttaaa tacaatcatt aagtacaata aaactactat
    19681 ctactcaatt ttttgaataa aaaagaatct tatttgtttt tttatacaat tcaatagggt
    19741 aaaataaaaa ttaataaatt agacaataaa aaagaatcta taaatagatt ctcttaataa
    19801 tatttttatt taattaaaat tctaataata ctcttactta atcataatta attattttta
    19861 aaataccttg ataattcagt ttctttaaca taaaaacctt tattgtcaat tttaataagt
    19921 tcttcttttt gcaatacctt tatcattctg gaaacagtct cccttttaca gccaagcata
    19981 tcagctaaat atgtaactgt aatatttaca tttagtaaag tccattctcc acagcaaact
    20041 ccaaattctc tacttaacct atataatttt gctgcaagtt ttttatctac ttttatggat
    20101 atagaatttt tcaactgtct atataaacgt cttattcttc tttccatata agaaataata
    20161 tcctttgtaa gttgaaaatc attttgcata atttctaaaa attcttcaat actataataa
    20221 gctacaattg aattttcaaa tgcttcacag ccaacagtag agtttttaga agcgtcaagt
    20281 gtaatatcat ttatgacttc cccactattt aatatgaaaa ttacttttct ctctccattt
    20341 tcacttatct taaaaataga tacctttcct tctaaaagta tataaacact gtctaagcta
    20401 tctttttcat aaaataaaat ttcttttttt tgtaatcttt ttagtttaac tttttcttta
    20461 agttgattct tcgttttagt acttaaatta ttaaaaatta ttactttatc aatattataa
    20521 tcttttaatt tagacatgta atatctctcc attcctaaat ttttaagaga gctctataaa
    20581 acattacaaa tttcttattt tattcatttt taaacaattt tatagcattt gtagttttaa
    20641 ttttcctttc aatagcttca ttagaaagtt cttttactac ctgtgtatat actaaatcaa
    20701 taatgaaaaa ttgtgctaat ttagaagata ttgaaccagt ttccagtact gtttctcccg
    20761 atacataaga taagtgtaca tctgaaatat cctttaattc agaattttta ttttcagtaa
    20821 ttgatataat tttagcatta ttggctcttg caagctttac agtttttata atctcttctg
    20881 tttcaccaga atgtgaaatt gcaattatta aatctccttc ttccattatg gaagacatca
    20941 ttatcattgt atgactactg tcaaaactta cacaattaag acctattctc ataaatttat
    21001 agtttgaatc ctgtgctatt ataccagaat atccaatacc tatgaagtaa actttctttg
    21061 catttattat aagccttgcg cagtcatgta catccttact attgattatc tctactgtgt
    21121 tctctaaagt ggttacattt gaacttaaaa gtttttttgc tgtatccaaa gctggctcat
    21181 cattttgtat atttttattt ataatatttt ttttattgat agttgatatt tcttgtgcta
    21241 aagtaacttt aaaatcctgt aatccattaa aattcatttt ttttacaaac ctagttatag
    21301 ttgcttcacc aatattgctc tctttagcta tttgtgatat tggtttataa aatacatcat
    21361 ctatattttc ttttatataa gctattaata atttatctga ttttgtgact ttaaaagttg
    21421 gtgattccaa ttgttctaaa atactcatta aaaacccttc tattctttat attttgttta
    21481 aaaaattata taatgctcca agcattcctg catcattttg tctctttgca aattctatat
    21541 tagtgttttt gtaaactctc tctataagaa cctcctttaa tgctttgtct atttttggtt
    21601 ttaggaactt ttcttgtgcc ataatcccac cacctaaaat taccacttct ggatttatta
    21661 cataacatat atttgcgatt ccaactgcta atgattttat catattatcg agttctttta
    21721 aacaatcttc atcattattc tttgctaaat caaaaattat ttttccattt aagtcatttt
    21781 cattcaaatt ttttattttt gctacttttt taattagact gctagtagat gccaattctt
    21841 gaaaagaact tccatttaca ttcatatatc ctacttcacc agcactatta ctaaacccat
    21901 ttatcagttt attatttatt ataatacatc caccaattcc agtacctatt gttaaacata
    21961 tagaagatgt tgcatcttta cctgctccaa gccacatttc accaagtcca gcacaattaa
    22021 catcattttc aacttcacat tttatattaa actctttttc tacttctttt tttaattgca
    22081 tgcccttata gtttggaatt aattcttcta atgcaaatag tattttacct tcaactgggt
    22141 caaccatacc tgcagttgat atacatatac cacttatttc attttcctct atatattttt
    22201 ttactatatc ttttattttg gctaatattc cttctccacc tttttccttt gcttcagtat
    22261 caagacttga tttatcaatt ataaatccat cttctctaat aaaaccatat tttattgaag
    22321 tacccccaac atctatacaa acgtaatttt tcataacata tctccataca aattattttt
    22381 ataaattaac aactctattt aaaattttat attacacaaa tcttttactt atcttttcca
    22441 attcacagat atatttcctt gcttctgata agtctatagt atcacttaat acactttttt
    22501 ctttggttat atgatactta taaatatttt tacataagtc ctctcctaac atattaagac
    22561 cttcttgagt gtaatgaaca tcatcaatag ttaatcctct gtcatgaaac tgcatagcaa
    22621 ttttgcttcc tacacataat atatcacatt cactacaagc cgactcctgt gctgctgcaa
    22681 ttcgtcttgt tctaataaaa tattcatctt ctccaagcca ataaccagtt aaacttacaa
    22741 acattttatc aatcatacat tcttctttaa gcctatacgc aatttttttt agactttctt
    22801 tatagtacaa tacatcacta ccatattttg catcactttc accttgaatc caaataacgt
    22861 atttattttc tatattataa tgtttactta aggtagtaca gcctgtatta aatttttcta
    22921 tagtgtcatt tagaaaccag ttattatcat gattccagtt ttttattctt gaaccatctt
    22981 ttgcattgtg aataaaacaa actttatttc cagtaagctt attccattca tttgaaaatg
    23041 caggtgctat agtaccatca ccttctgaag tctctagctc acatctcata tttataattt
    23101 catcagtact caaatattca aaacaatttt catttggaat gatgctctct tttggatttc
    23161 ccaatcctct agcattgctt tgtcctatta ataagaatac atctatattt tccataagtt
    23221 aactccttta caaaatttta agcttttaat tattttcaat tttctcataa aaaactaagg
    23281 ctgaaaatag taatctaact aaaatttacg aagtctcact aatcgctgaa agttaaatca
    23341 ctattttcag ccctagtggt tatataaatt atcattatct aaccaaaacc ttaaaaatag
    23401 cttttttgat attttctttt tctaaaactt ttattcctgt catatgagca tcttccggat
    23461 aacaaactaa aaaatcacct tttctaagtt ccatgtatcc attattttta ccatcaagag
    23521 gcaagaaatc gcccttttct tcatatattt tttgttctaa attttctata aaatttatat
    23581 ctattcgttc acatccatca agcatcaaat gaacatctat atacttctta tgagcttccc
    23641 agaatctatc ttctttttca caagttttat actctacaat attcacaaaa atatcatcac
    23701 catctattgt ataagtacct ttttcataat ctattaatga attatcttta gcatattcaa
    23761 aacatctaag taaatcttca tgcaatgttg aatatgtctt actatgattt atatttccaa
    23821 atatcataag cactatctcc ctatataatt ataaagtcta tttttatact tttatataca
    23881 aagtatatta tacaatctta tagagtaact aaattattta tctaatcact ctataagaca
    23941 atttatcatt taaatattat ttttcataat aaacagtagt ctcagctttt ggtaaagata
    24001 cttttgcttt aactttagct tctattgcac taactattgt acctaccact acagaagtcg
    24061 tgattgttat tagagaatat gcccaagaag ttacttctgg catacggtat tttaaataaa
    24121 caactaaaat tgctgatact atgaatccaa catatgctcc cattttagtc gcttttttac
    24181 aaaatgcacc aagtacaaat attcctgcta aaacacctag tactagcccc ataaaactat
    24241 taaaccattc atatgctgac tttatttctc catttgctaa tactattgca acagctatag
    24301 aaagtatacc tacacctaat gatatatatt gtgctatctt agtttgcttt tccatactta
    24361 tatcttttgt tatgatagtt tgtatatcta aagtccaact tgtagcaact gaattaagcc
    24421 ctgtcgataa agttgattga gaagctgcat atatcgctgc aagtagtatt cctgttatac
    24481 ccactggtaa ttcataagct atatatgatg caaatacttg gtcttgttga actgtttgag
    24541 ctaaatctgg gttttgagta tagtatataa ataaacaagt tccaattaga taaaatactg
    24601 ttgcaagtcc cattgataaa acaccatttc catatgtcat tttattaagt tgctttatat
    24661 cagttgttgt agtaaatctt tgaactatgt cttgactcga tacatatgat gaaaaagtat
    24721 taagaccagc tccaacaaat attataaatg cacttgtaga tagtatattt ttatcaaaca
    24781 taacttcatt acttgctaag aacttgtgtc cagttgtaag agtatccatt actgttccaa
    24841 aaccaccatt tatacttgct attaaataga acaatgtccc tgtaacacct actattaata
    24901 ccattccttg tataaaatcg gtccacaaga cagcctttaa tccacctgta tatgagtaaa
    24961 ttattgctat tacacccata actattatca gtacatttac aggtattcct gtaagaccag
    25021 ccagaactat tgatggaaga tacattatga tagacatacg tcctatttga tatattataa
    25081 acatcaaagc tccaagtact ctaagacctt tgctttcgta tctcatttct aagtattcat
    25141 atgctgtatc tatttctaac ctactatata gaggtaagaa aaattttatt gtcaaaggta
    25201 ttgctataaa catacctaat tgtgcaaacc acaaaatcca agtaccacca taagaatttc
    25261 ctgctaatga taaaaatgat attggactta ataatgtggc aaatattgat actgatgtaa
    25321 cccaccacgg aatagttcca tcacctttga agaactcttt tcccttcatt tccttttttg
    25381 aaaataacaa tcctgcaaat aaaactgcca ataagtaaac cactagtatt gcaaaatcta
    25441 tccaagtaaa tcctaccatt tgactaatcc tcccatacta aaagtatttt attaaaaata
    25501 ctttctgtat atttcttttg ctcttgattt catttcatca gttgcttctt tcataggttg
    25561 tctacagtat ccagcctcaa caccttgttc ttcaagtagt aatttaattg tttgatataa
    25621 gccatttcct aatatatctg ttattaaatc attagtcaca tgttgtactt caagtgcttc
    25681 tgatattttt tcattcttag ttaattcgaa tatttgtcta gctctgacac cgtttacatt
    25741 gaatgtagaa ccaattgccc catctacacc taaaactgta gctggtaaca tcatttcatc
    25801 aaatcctgca aatattaatt tatttgggaa tgtttttctc attctctcta ataagtagaa
    25861 atctgctgct gtaaacttaa cacctattat tttttcattt tcaaataatt ctccaaactg
    25921 gtctaaactc atatcaacac cagttaaaaa tggtatagag tatattatta atctattatc
    25981 tacagaattt attattgtat tataatagtg ttttatttct tcaaaatcaa atttatagta
    26041 aaaaggtgta acagcactta ttgcatcata tcctaaatca gttgtaaatt tagcaagttc
    26101 tacagcttct tttaaattaa ctgaaccaac ttgagctatt aattttattt cttctttcac
    26161 ttcatcttta gctatttcaa atattctttt cttttcatca gttgaaagca tgaagttttc
    26221 ccctgtactt cctcctacat aaagaccatc tactttacaa acatctatat tgtgtctaat
    26281 tatttgtctt aacccttttt catttatatt tccttcctta tcaaatgaaa ctaataatgc
    26341 tgaataaatt cccttcatat ctgttgttct catatcttta cctccaattt taattttcaa
    26401 atatagttaa atataataat tttttaattt ataaattaat ttttaattaa tttcaattgc
    26461 tttaacaaat ttttctgtta ttaattgtgg tcttgttatt gctgaaccta ctactgatga
    26521 atgaacaccc aactcaaaga ccttttttaa atcttgagga gtatttacct ttccttcagc
    26581 tattacaggt atttctaaat ctttaactaa tctttccatt aatacaaaat ctggaccttc
    26641 taatgtttta gtatatggag tatatccaga tagtgtagtt gaaacgcaat ctacaccgta
    26701 ctcttgtgct ttgatagcct catcataatt tgaaatatct gccattacta gaacaccgtt
    26761 ttcttttata tactttataa gttcttttaa gtcttcatta tttggtctaa ctctattggt
    26821 agcatctaat gctatcattt cacaccctgt tgttaaaagt tcatcaactt cttttttagt
    26881 tggcgttata tatatatctg aatcttcata gtttctcttt ataataccta taacaggaag
    26941 tccagtaact ttttttattt caataatatc ttcaactcct tgagctctaa ttccaacagc
    27001 tccaccttcc atagcagcct tagccattct ccccattata aaaggactat gaagaggttc
    27061 atcttctaaa gcttggcatg atactattaa tcttcccttt accttatcta gcatttttta
    27121 aattacctcg tttctgaaat ttattttctt gatttatgta ttaataataa catgaaaact
    27181 ttttctttgc aatatttttt catatttttt tctcgcatct atatttttac tgatttattt
    27241 tatatattag cttgtttttt acatttaaaa gaaattttat ttcatttttt tggtgtttat
    27301 tttcatttta tataactact gttataagtc catttaaata atttcaataa aaaaacccat
    27361 gtatactata cataggtttc ccaatattat tctaaatcca ttataatttt tcttccacag
    27421 catggacaaa attcagcctc tgtatctatc tcactttcac aataaccaca aattataaaa
    27481 tcatcacatt cattttccaa ttcaaatttt ttaccacatt cagcacaata tttatcattt
    27541 acatttccaa cataaccaca ctcacaagtt acattacttt ctgccatttc catttcatta
    27601 atttccatat ttttttcata aattaactta tcaagttcta gtaactcatc acagaattta
    27661 tcaaaactat tatcattaat agaatcttct ctaatttttt gatatgtcag tattcccatt
    27721 tccaagaata tctttgcttt cttttcttga atatcatcaa tctctctatt taattttgat
    27781 ttttctttat ataattcaac tttaaatttt ccactaccaa actttttctt aaccttagaa
    27841 aatttatcat ctactttatt attagtattt ccttccacag aaattccctc caatcatatt
    27901 taatcagctg aatttagctt atatcctatt aaagatatca caaaactata tacaaatgaa
    27961 attacaatag cttgtaagac tttaaattgc attattaaag ttgttccata attagttgta
    28021 ttaaagaaat taatattact atctagtata aatgtactaa ataaagccaa tattcccatc
    28081 aaaaatgcat aatatatact aaatactatt ataggtctta tactatctgt attatactta
    28141 aatcttagct tgtatccatt taataataat attaacatag acaatgctcc cattgcataa
    28201 aacattaatt tagtatctcc aaataaagat gaagaactta aagtaaacat tgatactgtt
    28261 gagtttatta tggttactga aattccattt gcaaaagccc acatataact agctatttgt
    28321 gggagtatag taaataaatt taatccattt gaataactac tcatatctag ttcatttaag
    28381 taactactat cagatatagt tagtaccaat agtattacta atactaaaac ataacctaat
    28441 atgaatgttc ttatagaatt tgaaaaaaga gataaataca tattttcctt ttcataactt
    28501 tttttataag tagttatgta tgtacatata aaccctaata caaatccatt taaaagaaca
    28561 ctaaaaaatt cataactata ttctaatgca tatccatatt ctaacatact atgtgaacta
    28621 gtttttacat tagtaaaaat agataaaata gctaaaacta atccataaaa aattccaact
    28681 cctagagaat ttgctaatac agtttttgaa tctctacatc tttttctcat aaaaattagg
    28741 tttgatatta ataataccaa aatagggatt ataagtaata tcaacaaacc tatattggca
    28801 tttataaacc cagaacccat catggtagac atagatacac taatttgacc caagttgaga
    28861 gctaggatta tatgtgctgg atttattaaa taactaatat cattaaattg aatagttata
    28921 atagctttaa atatcaatgc aataataaac aatataaata tggttgtaaa tgttgttaaa
    28981 aatacacctc ttttatttgc atgatatgaa agctctttta ttttagattt caagtctagt
    29041 tttgtttcaa gtggtcttaa tgatgctatt tcataaagtt catttccaca aaatttacag
    29101 taattatcct tagtattatt ttctttattg caactagaac aaattttttc ttctttactt
    29161 ttaagagtga tatggctatt ttttattttt ctagttggtt cacctgtctt tttggaataa
    29221 ttattatgtg aataattcat attatttatt ttcttttcac ccattttttc cctccaagtt
    29281 ttactattgt aaattatcaa atataactat atcatataaa acttaattat accttaattg
    29341 gatatattta tctattttat ttgtttattg ctgttgtttt ttaacaggtc ttgatattta
    29401 aatagtttgt taatgcgaac tttattattt atattttatt atgcttaatt taaatttatt
    29461 ctattcttta ttttcagtag taaactatct gtaaatctta attataataa agtattaatc
    29521 aataaagtta ctcgacatta tctaataaat tttatctatc acaattttag attgttacac
    29581 acaatatatt ttgatataat taaatcataa acgaagtatt ccaaatatct aatgatagaa
    29641 aggaatactt atttttatgc tttattttta atggaggctt atatgaactt agaaaaaata
    29701 aaaaaatttt ttggatttcc tctagacaaa aaacacaaag acaatgttga gaaagaactc
    29761 tgcaattatc tttatcatac gggtaaaatc atttgcataa taatagtaat atctcaaata
    29821 attatgatga tatcaatctc agctagagaa ggaggccctt ttgtcacacc aagacgccaa
    29881 tggtattttt atatgtatgt aacactattt tgtgtatctt ctgtctttat gtttgtattt
    29941 tcttaccttt ggaataaaaa aaaggattgc tgtacgtttt atataaattt atggataatt
    30001 tatgtgactt ttttctgcct atggggttgt gtaattactc tacttgacca gttaggtgga
    30061 aatgacctaa gtgtatttag ttatattatg ttagcagctg cagctttctc agtattaaaa
    30121 tttggagaat cagtaatagt ttttggagga tgctttttgt ttcttaattt attcttacct
    30181 gggattcaaa ctataccagg caatgagttt agtaatattg tcaacacatt ttttataaca
    30241 tcccttgcca tttttgtttc tacaatgcta tatagaaatc gtgtatttac ttactatgat
    30301 aaacttttaa ttagtcaaca atatgaagaa atatctcata taaataattt acttaacgac
    30361 aaagttatga cagatgacct tactaaaatg aacaaccgta ggtaccttga agatattcta
    30421 caaaaaaaat taatcagcca tgcaaatcaa gaacctataa ctggaatgat gatagatata
    30481 gattatttta aacaatttaa tgataattat ggacatcaaa agggagacta ttgtctacaa
    30541 aatattgcca aagtaatttt agattttaca agttctgaaa atgaacatgc tatacgatat
    30601 ggtggtgagg aattttttat atgtattttt aactgtaatg aggcagatgc taaacttaaa
    30661 tcagaatgtt tacgaaaaat tatagagtcc tgcaattttg agcgtgatga tgttccttta
    30721 aaatgtgtaa ctgttagtat tggagtttat acaaagaaaa ttggaaagac aataacatta
    30781 aatgagttta taagtaattg tgataaggcc ctatatactg caaaagaaca aggacgtaat
    30841 tgtgttgcat tttattaaaa ggttacatac tattacataa acctataagt attatatcgc
    30901 aaaataaaag taatcaaatt atatatttat agtacaataa aaataacttg catatctcta
    30961 aaatagataa atatgcaagt cattttagtg tttatactta aagttatata agttttatta
    31021 tatataatta ttaaaattca gcatttttag gagttcttgg gaaaggtata acgtctctta
    31081 tgttagacat acctgtcata tacataatta ttctttcaaa tccaagacca aatccagagt
    31141 gagtagcagt accaaacttt ctaagttcta aataccacca ataatcttct tctcttaatc
    31201 ccatttcatt aattctatct aacaatacat cttctctttc ttctctttga gaacctccta
    31261 cgatttctcc aactccagga actagtaaat ccattgctct aacagtttta ccatcttcat
    31321 tcattctcat atagaaagct tttatatctt ttggataatc tgtaacaaac actggacaat
    31381 tatatatttg ctccgttata tatctttcat gctctgtttg aaggtcacat ccccactcaa
    31441 caggatactc aaattcatgc ccagattcaa ttaataattc cactgcttta gtatacgtta
    31501 ttctaataaa ctcagagttt actatcttat ttaatctttc taacaatcct ttatctataa
    31561 aactattaaa aaattccatt tcttcaggag cattttctaa tacatagctt ataacatatt
    31621 ttatcatatc ttctgcaagt tccatgttat cttcaaggtc tgcaaaaact atttctggct
    31681 ctatcatcca aaattctgaa gcatgtcttc ctgtataaga gttttcagct ctaaatgtag
    31741 gtccaaaagt ataaacgttt ctaaaagaaa gtgccattat ctcggcattt aattgaccac
    31801 taactgttaa attagcctct tttccaaaga aatcttgagt atagtctatt ttgccatctt
    31861 cagtttttgg aatatcattt aaatccatag ttgttattct aaacatctct cctgcacctt
    31921 cacagtcact acctgttatg attggagaat gtgcatatac aaagtttctt tcttggaaga
    31981 atttgtgtat tgcataggca gctattgatc ttactctaaa tacagctgaa aaagtattac
    32041 ttcttggtct taaatgtgct atcgttctta aatattcaag cgtatgtctc ttcttttgta
    32101 gtggatacga actatctgat tccccttcta caactatgct ttttgcatgt atttcgactg
    32161 gttgtttagc cccttctgta gatactaact ctccctctac aagtatagat gagcttattg
    32221 ctaattttcc tacctcttta aaattttcta ctttctcatc aaatactatc tgcatatttt
    32281 taaagaagct tccatcattt agctctataa atccaaaatt tttagatact ctagatgttc
    32341 ttatccatcc agctactttt acagtcttcc ctatgtactg ttctttttct ctgtacaatt
    32401 cttttactgt tataaattcc ttttgcattt taaatcctcc tagtataatt gttattaatt
    32461 tcttttaaat ataatttcaa taaaaaaagc ccttcatccc tatataaagg gacgaaagac
    32521 tattactctc gcggtaccac cctagttgtc ataatgacct cttagttaag caatgcttaa
    32581 agcctataac ggtgccttcc gtctaagtct acttactaaa taagctttcg attagaaact
    32641 ccaagatgtt cttcaatata aacctcgtat tgagctttca ccatcctcaa ctcgctagaa
    32701 ctacatttta tatctactct tctcttcaca gtatttatct tttattattt ctgctaatta
    32761 acaaaattat accaatttat aaatttttag tcaataaatt tatataattg atactgattg
    32821 ttatttaaaa tataataatt ctaccttaca taatgataat aaatacttat cttcattact
    32881 tctttattac ttcaatttcc aaaattttat aatttacttc cattgtcaac ccagtctttt
    32941 gcttcttcga cacccttaat tgaaggtatt gaaactttac tatgaggttt taatttttca
    33001 acatcagccc atgctgctgt cgactcattt ccaactaaaa gtgaactttt aagtctttta
    33061 ttatctttac cttttaatgc tcttgccttt ttactttcca aaactatcac ctctattatt
    33121 tattttgtaa tagttttagc aattttacaa ataaaattca taagtctaaa ttataattat
    33181 ttttaaatta acataatatc ttttcaatac ttaatttata cctatttata tacaaaatat
    33241 ttactttgtg tattcaaaat ataaaactgt tttttaattt tcatatttat tttttatgct
    33301 atttttctac tctatctaaa gtatttgata caattaaact aataatcaat tataatttta
    33361 cataggttct tatctataga gtatttgcta tctgttgaat cgtatttttt aaatttaaaa
    33421 tcccatatcc ctgcgataca tttggatatg tatatatctc aagttttgta gcacccaata
    33481 ttaaatatgt ttttaaaact tgtgtaaaca atgataatct cggtacatta tcctgttttt
    33541 ctaagtattc catcaataag gctaaaacac ctgtgactat agaactgctc actcctgttc
    33601 ctgttcctgt attatatgtt ccatttttat atgtggatat tatatctaca cctgaagcta
    33661 ctatatctgg cttaattcct cttcctctaa ttggtccttt cgaagaacca atccacatac
    33721 tatcagtctt attgttaaat gtaccaactg taattacatc atcactagca gcatacatag
    33781 ttatagtagc tactgaatca ggctctaaaa accttgtgtc tggagctatc aaatttttat
    33841 ttggcaagta tatgtcatat tctccattta ttataagttc tgaagtcaat cttaaaatcc
    33901 atactccagg ttttatatct cttaatctta tctccaaatt ttcttttcca gaggtaatat
    33961 atggataaat aaatctcatt gcataagtag tattttctaa gttaaatttt cctctatata
    34021 tataaaagtc tggagaatac cttatatcat gactaacttc acctgaagga gatattatct
    34081 gtgctcccac tttatctgga ccattcgtat ttagtgttat atcaagagca tagtcatctc
    34141 catcttgtat tattacatct tgaacttctc ccacactgct aaatctgcca gaataatgaa
    34201 tatctgtatt cccttgattt cctgcaccac tcactactac cacaccagca ctactcaata
    34261 tattaaaagt atctagtatt gaagtagttg ctacagcact tgacttaact ccaatagtca
    34321 aatttattat cagtggttta ttttctgttc ttgctatgtt agtaacatac gttatagctg
    34381 ctaaaaaatc tgaaacactg taatttatcc ttccagcata ataagtatct gtatatgatt
    34441 ttaatttaac tactattaag tctgattctg tagtaatacc tctgtactga gaatttatcc
    34501 ttccatttcc aactaatata ccagaaacta aagttccagt acctatatta tcttgactca
    34561 aactcccatc atttctattt atggctatat ttaactcact tcttgtaaat tcacttccaa
    34621 aaataaaacc ttctggaggt ggatttgtat ttgcttcttg gtcccataaa tataaaactt
    34681 tactagttcc atcatcattt ataaaatcag gatgcaaata atctatccca gaatctataa
    34741 ctgctaataa aattcctctc cctgttatat cattatatgg attttcataa atataatcag
    34801 tttcagctgc tgttgtaatg gtttctccat tatttacatt attagttatt tcaattagac
    34861 tgctcattgg ttcagattct tcccaccaag caacttgtat tatattattt aaaatagttt
    34921 catcaaaatc taaaggtaca tatattactg caagctgact atttaaaacc atatacctat
    34981 ttattccatt ttcttgtagg gcagattcta tatcaccttg ataaattata caataagatt
    35041 tttccataaa tccctcctat cttaaaacat caaacattcc tctaacatcc aagagcccat
    35101 atccagaatt tgtatttgga tatactgtgt ttgaatcttt tctagcacca gcttgcataa
    35161 aagtttttat tttttgcaca tatgcttggt ttggatatct accgtcaaca aaagtatatt
    35221 gaaaatacat tgcagcagca ccagctgcat gtgcacttgc tgctgctgta ccagttatag
    35281 ttgcatacgt gttcccagga taagcagcta ttatattgac acctggtgct actatatctg
    35341 gttttaacct gtcttcaata gttggccctc ttgatgaact ttgccataaa ctaccattaa
    35401 tggtattgta ggctcctatg gttattaaat catcttgaat cgcaggataa tttatagtgt
    35461 aaaaagggtc tacctctcta aatctagttc cactttttaa aagttctcta tttggaaggt
    35521 ataagttata tcttcctgtt ataatataaa ctcctactaa tcgaatcttc catacacctc
    35581 tttttgcatt ctttaaagta acattagtaa attgctgtcc agaaaaagtt gttgggtata
    35641 tatatgttat agaatattca gtcccctcta aatcaaataa acctgttact ttattataat
    35701 ttgaaattcc aacactttta ctttcttcac cagtgggaga tactattatt acatcagctt
    35761 tatctggtct atttaaccaa agttctaatg ataattcttc ctcgtcttca tttaactcta
    35821 attcaacttc aacagaacct ccaacatatg gtattattcc agatgtatgt gtctgtgtat
    35881 tgccctcatt tcctgctcct gccgttatac ataaccctct agtaaagaac gctttttcac
    35941 tattactcct attggttaaa cctgctaggc tactggtacc taaagacata tttataacta
    36001 atggtcttcc aagttcaaaa gcttttttat atgcatactg agatgcagca aacaacattg
    36061 cactattata aaaatcatct atcttgccga gttttattat tattagctca gaatcttctg
    36121 ctatacctgc atattcacta tttacatttc caagccctgc acatatccca ctcaacatag
    36181 ttccttgacc aacttcatcc tgagatagac tagggtcatt ttctgcgata gctcgattta
    36241 tatcttctcg tgtatattct gtcccaatat aaaaaccatc aggaggagtt ccttcttttg
    36301 tttggtccca taaatatact atttttgaag tgccatctgg ataaataaaa tctgggtgta
    36361 gatagtctat tcctgtatct gcaattgata ttagagtccc tcttcctgtt atattaatat
    36421 taggattatt tttaaagaaa tttacgccca tttcttctgt tgcaactaca cctccaaaag
    36481 tacctcgatt aatttctcca agtaatgtca tctttgtagt cgatacagtt cttatgattg
    36541 aaggaagttg caaaactcgt tgtatgctat tatagtctgt attatttata gatagtacac
    36601 ctaatgaatc acttatctta aaaaaccttt gactcatacc taacccagct agttcttctt
    36661 caaattcagg agtatggact atatctattc ctgatagtat tcctgattgt ctacttgcat
    36721 ttttacttat ataaatttca ttctctaagt cattatgtat ttgcatatta taaccatcta
    36781 taaacttata actattttcc tcatctttaa atgacttatt aatacttcta tatccaatat
    36841 cctctgtttc taaatcttga tttatattag atagagtgta caaatctata tctgataaat
    36901 ttaaaaaacc aaatcctgat gaattatttg gataagattg attacttaat ctccttgctc
    36961 cctttagaag taatgccctt aatttctgtg aatacaaaaa taaatcattt ccatttacaa
    37021 ttccccattc cataaacaat gaacaaaccc ctgtaacatg aggtgtagcc atgctagttc
    37081 cagttaatgc tccacttgta cctcctggta aaaaagatac tatatcttca cctggagcta
    37141 ataaatcagg tttaaaaaca cctaattgtg tatctccttc accagaaaat atagatacta
    37201 tatctgttct tgaattaaaa ctacctactg ttataactct acttgctgtt ccaggaactg
    37261 ttacagtaag ctcttgagta ggaatcagaa atctagtatt tctatttaga ccttcagaag
    37321 ttggcaaata tatatttaca ttaccagtta ctatatctat tggttcaaat acaattttcc
    37381 ataacccagg agttatctgt gtatttgaac ttaattgtag agtaactctt cttgtgagag
    37441 aatacggtgc tatagggtaa aaataaccag ttattctagt ttcacccaaa gtattcctta
    37501 tctcacctga agttagagag attgcttgtg tttgattatt tgatgggttt accaaatgta
    37561 cactaaaatc atcaacaaaa tctggccata tatttatgtt taatatacgc tctccttccc
    37621 caactataaa ctcaacttct tctgtaatat tattttgaag cctaatcctt ttatgacctc
    37681 ctttatctgc attatttcca gctgctacaa ctatattgtt tttccaaaat aaacacatat
    37741 catctatata ttgttcaaat aaagatgttc ctctatgtga accttcatta cttccataac
    37801 ttatatttaa tgtaacaggc attcttaatt ctaatgccct atctaaaata aatttaattg
    37861 ccctcataaa ctctgtactt ctcgaaaaaa tatcggtctg tatatttcca actctaacca
    37921 ctattattct ggcatcactt gcaatagttg cacaaatacc tgcaacatgt gttccatgta
    37981 agctagttgt tgaaataggt atatacatac ttccatctat tgcattattt atatcttcat
    38041 tagtatataa tgttccttct ctaaaacctt ctggtggatt tccttgaata gattggtccc
    38101 aataatataa tatcttagac cttccatcac tatctctaaa cacaggtaga gtataatcta
    38161 ttcccgaatc aattatacca attatagttc cttttccagt taaaccagtt ctatttttaa
    38221 atcctgttat tcctgtactt gaaaaacttt gcacatcctg agtctgtaat ataaaaggct
    38281 tttctataaa ttcaatttct ggataagtta aaagtatatt tacatcttct tcattacttg
    38341 atgttattat tgcatatgat gaattaagta tctctactga tacacctaat tcttcttcta
    38401 acctcaatat atctccattg tattttacaa ttaattcata atttattata atcacctcga
    38461 cttctaaaat tattattaat gtatatgttt tgtgtgagtc taaaatgtat tagactatat
    38521 aattttttaa gtttcagtta tacaatttat aatagatata ttaaaaaaat aaataatgat
    38581 ggtacaattt tgaataaatc ataccatcat ttatatttac tttatcttga aaccattaaa
    38641 tttttcaatg ctttctcaag accttttaca gtcaatggaa acatattaaa ttcactttgt
    38701 atcattcttt gagtttgata ccaataacta attgaatccc atccatctct aagttctgga
    38761 ttcatccata caattttact gtactttctc ttaaaccttt taagccactc tataccaggt
    38821 gtataattat atggaccacg atagttacca ccaatatgaa gcaactcaga aggcgacata
    38881 gaagcatctc caacaattat aactttatag tttttatcta tattttttaa tatccattca
    38941 gtattaatag atttacttaa ccaacattca ggtgttgtaa ataatctatc ataaatacag
    39001 ttatggaaat aatatatctt tacatcttta aaatgatttg atttacttac agactgaaat
    39061 aatgtattac ataaagtgct ataccctctc attgaaccac ctgaatccat aagcaataaa
    39121 agcttcactg tattttttct tggcttctca aaaaataact ttaaatatcc tgcattatta
    39181 caagtctctt caatagtctt atccaaatca agctctgtct ttggagcatc tattctagta
    39241 gaaaattgac gaagtctctt tagtgcaact tgaaattgac gcatatttaa aacttcatca
    39301 tctctaaaat ctctgtattt tctttctcct gcaacttcaa gaacagctct accataagta
    39361 gaatttccac ctatacgtat accagtttgc ccttttcctg aatgtcctaa ctctgaagtg
    39421 cctcctgtgc ctatccaata attaccacca ttatgaggag aatcttgttc ttttattcgt
    39481 tcctccaatt tagctcttaa tttatcaaga tttatatttg gattttgttc taatctttca
    39541 aactcttcta aatctatatc tggtttttta agccaattca taatctcttc tggaatttct
    39601 tcttggtgtt ctataccttt aaaatactcc aaaaacactg catcaaactt atcaaaatca
    39661 ctttcacttt ttattaaaat catcctgcaa agatagtaaa aatttgaaaa gtttgaatag
    39721 cacagtcctt tatccaatgc ttcaattaaa gtcatccatt catttaaaga tacatttaat
    39781 cctcttgacc tcaataaata aaaaaattca ataaacataa ttatccagct cctattaact
    39841 ataagtgtct ttgcatagat tcaatatcct cattattctt aagtagtatt cctgcaaaag
    39901 gaacttcttt ttctattttt tcaataggca ttccactcaa agttaatgct tgtatccagt
    39961 ctattaactc tgatgtacta ggcttttttt gtatgtcctt taaacttcta atccaataaa
    40021 aagtagtcat tacttgttcc aataggtgtt cttctacttt atcaaaatgt actttaacta
    40081 tttcttccat catgtctcta tcaggaaatt ctatataatg aaatatgcat cttcttaaaa
    40141 aagcatctgg aagttctttt tccgcatttg aagttataat aactattggt ctttgtttag
    40201 ctcttacagt ttcttttgtc tcatttatgt aaaactccat tttatccaat tcccaaagca
    40261 agtcatttgg aaattctaaa tccgccttat ctatttcatc tattaaaaga attacttgtt
    40321 gatttgagct aaaggcctct cctagtttac catattttat gtacttgcta atatcatcta
    40381 caccttctcc tccaaattgg ctatcataaa gtctttgaac agtatcatat acataaagcc
    40441 cttcttgtgc ttttgtagtt gattttatat tccaaattac taaatctttt tttaattcat
    40501 ttgaaattgc ttgtgctagc atagttttac ctgttccagg ttcgccctta atcaaaagtg
    40561 gcttttcaag agcaatagca acattaactg atgccatcaa ttctggtgat actacataat
    40621 cactacttcc tctaaagtta gatatctctt tttttatcat aaatcctact ccttttaaac
    40681 agtattttct aaatgtatat agactttatt actatttttg atataaaaat aataatacaa
    40741 tacatttgta tagtattatt ctaaaattct atatctaaat aaaatcacct ctaaaatatt
    40801 taatttttat ctttatttgt cataattaaa tgaaatatat attttaaaga ataataaaag
    40861 atagcttatt gtacaaaatt taaattataa aaacttagtt taatcaaagg caccactttt
    40921 tttcatttta gattatatat aaacacaata taaataattt ttattatttt agctataaac
    40981 ataaagtttt aacgtattta taatttcata ttaatcatac tatattaata ctgcttttta
    41041 ttgtataata agctataaat attaacttta acttagattt aagtatatct aaatttaata
    41101 aatataagaa aggttgtgtt attttgcaag ataaaaaaat ttatctaaat attgtactca
    41161 ctgtagttgt ttcatatatc ttgattaaag ttattgataa ttacaaatat ttttttggag
    41221 tgataagttt attaatgtca ctactaacac catttataat agcatttgta ttagcatata
    41281 tattcaaccc actagtaaag ttcttagaaa gtaaattaaa ttttaagaga atatattcgt
    41341 tacttcttac ttatggtgta ctcatagtta tactaatttc gtttatatta tttacagttc
    41401 catccatagt aaatagttta gctgatttag ttgctcaaat tcctacatac atagataaaa
    41461 cagagcagtt tttattcgac ttaggcaaga gtttacaatc agttgaccct aatacattaa
    41521 aagagtatgg tgacaaaatt atgagtgtaa tgcctaaatt tagtaacttg cttattggtt
    41581 cacttggtgg gatatttagc actacatttt cagttggaaa atttatagta caatttcttt
    41641 taggttttat aatttgtttc tatatattat tagaaaaaga aaaattctta ctgtttacaa
    41701 aaaaagtagt ttatatttcc ttaggtaaaa aatatggaga ctttataata gaactatgtc
    41761 aaagcttaaa tttaaatatt ggtaaatact ttacaggtaa gattttagat tcttttatag
    41821 ttggagtact ttctggaatt ggtctttact ttttaaaatc tgaatatgca ctattatttg
    41881 gtacacttat gggtgtcatg aatatggttc catattttgg tccagtaata ggtatggcac
    41941 cagttgtaat aattaattta ttctccaatc caacaattgc tttaacttct ttaatttact
    42001 taataataat tcaacaagtt gaagttacat ttatagagcc aaaaatcgta ggtggacaac
    42061 taggtcttag cccattcttt acaatcctag cagttactgt tggtggagga ttctttggta
    42121 tacctggtat gattctatct gctcctgtga tgggcgttat aaagatatac ttctgtgagt
    42181 ttgtaaatcg tagacatgat aaaatacaaa tggaataaaa atacaattta attacgattt
    42241 tgtaatcaaa agttacagct gtgtaactgt aatattattc tctttaatgg taatatttaa
    42301 ttataggaaa catacaatat tattaagtaa tgaatcttat ataattaaac atgaaagagg
    42361 gttttagtat gaaaaaagca cttatatctt tattagtttt atcttgtttg ttattaactg
    42421 caccagtaaa tgaatcttct tatgcagatt ctcaaaagaa tgttcctgta agccaaaata
    42481 ctaaattgac tcaagaacaa gctaaagaac ttttagtaaa atacaacaat gaagttgatt
    42541 acatatatca aggaaatgct agtgattttg aagcattaaa agctaaaaat cttaatggtt
    42601 atgtattttt accagatgca gatggtgata ttggttactt tgtaaatgaa aatacttctg
    42661 agatatatta cttccaccca agtggatatc ttgaattagt taatcaacaa caaaataata
    42721 aataactaat aaaaaatgga tgcaaattga tataaatttg acatccattt tctttttatt
    42781 ttaaagttgt ttctttttat aaactttaaa tactttttta atcctgcgct tgttctttta
    42841 taagtttctt tatatctaca gcaggttcat cttccatttt tataactttt ccttcccatg
    42901 ttctaagcat aacgtaatct gttccttttg atacaaggta ttgaggaagc aaaggagtct
    42961 ttccgcctcc ttttggagca tttactatat atgttggtat agccattcct gatgtatatc
    43021 ctcttaaata ctccatgatt tcaagaccat catctactga tgtattgaaa tgttttgttc
    43081 cctttacatg tttactttgg aatatataat aaggttttac tcttattttc agtaattctt
    43141 gatttaaaca tctcattaca aatttatcat tatttattcc atttaataat actgcctgat
    43201 ttcctaatgg aactcctgca tttgctaact tttcacaagc ttctttagat tccttagtta
    43261 tttccattgg atgattaaaa tgagtattta tatatacagg gtgatatttt tttagcatat
    43321 tgcaaaattc atctgtgatt ctttgtggca ttgtaacaag agtcctagta cctaatctaa
    43381 cataatcaac atgtggtatc tctttaagtt ggctaagaat ccactctaaa taatcatctt
    43441 ttaatgtaag agcatctcca ccagttacta gtacatctct tatttcttca ttttctctga
    43501 tatagtctat agattcttgg ataatagctt ttgacttatg agaatcttgt tgtccaatat
    43561 ttcttcttct ctgacagtgt ctacaataca tagcacactc atttgttaca tttattatta
    43621 atctatccgg gtatcttcta gttatacatc ctgctgggtt tgtatactct tctcccattg
    43681 ggtccaaatc ttcttgttca tcttccaact ctatatgtgt tggtatagac agtaatttta
    43741 ttgggtcaca tgtatcttct gggtctataa gactcaaata atatggagat attgcccatc
    43801 taaattgagt accaacctct tttatatatt ctttttcttt tttagttaga gttataattt
    43861 ttgataaagt atctacatct gttattctat ttgataattg ccatttgtag ttattccaat
    43921 cctcttcagt tccatttaag atacttaata ttttctgttt tcgtttattt atctcttctt
    43981 ctttttcaag acctctgtta atcgtttttc tagcctgaat ataatcatca atttttgatt
    44041 ttaattcagc agctctctct aaggatattc tagtttgttc attcataatt ttttgctatc
    44101 aaagttaact acttgtatta tttgatagcg tcctcctttc tggtgtgttt atatcattct
    44161 gataggcaga tttaattttg ccatatagat tttataacaa atgaaattga attaattttt
    44221 gcattttttc tgttatttcg cacatttatg aatatttttc aaccttcgtc aataaattac
    44281 aataaattat gcattttttt taacaaatga ttaatttttt ctatttttaa gaattatttt
    44341 accataaaac gattatattt tcaagattat taaaattaaa ttttttaata aaaagtaaag
    44401 tatttcatta aataataaaa gcggaggttt attataataa atttctccgc ctttttattt
    44461 atttaattaa ataatagtaa aataaattta actcttaaga agtgacttta ttatattaag
    44521 ccctttttct aattcttcta catcttttgg agctgttaca caaatacgaa ctgcttttgg
    44581 aactgtagag tttcctactg aaaatcgttc agcacaatat acttgaactc ctagattttt
    44641 tgcagaaatt tcaaatgatt ttccatccaa ttcatcagga agaagtaacc aacgaaaact
    44701 gcaattctta tcaccaatca aattataatc tgacaaaact ttatcagcaa cttcatttct
    44761 ttctataatt gcatctcttt tctcttctat aattttatct ataataggag aatataataa
    44821 acggtgtact atttctgctg taaatggaga aaccattaga ttcatattat atagtgcatt
    44881 ttctaaattt tctatatatc gttttggagc aactacaaat gctactctaa gaccagcaca
    44941 taaaaattta gatgtactaa aaatatatat agtattatca ctagctaaag aaaatatggg
    45001 agtttgtata ccatctctaa aaatgctatt tatagcatct tcaataatta ttatattata
    45061 ttgctttgct atcttggcta tctttttacg agataaatca gacatagtat gtgtcgttgg
    45121 attatgataa tctggtataa gatatatgcc ttttatattt tcatttttac aataactttc
    45181 aagatattca atcgatattt cattattttc ttgaggaatt gggactaatt gaatacctat
    45241 cattttagct attgacttaa ttccagaaaa acttaaagaa tctgtagcaa ttctatcacc
    45301 agctttaaat aatcctagta aagttgcaca tatagcattt tgccctcctg tagataataa
    45361 tatattttct tcactggtgt atacattatt tctttctatc cattttgcaa ttgacttttt
    45421 ttgcatatat gtgccagatg gagacatgta ttgtaaaaac ctatccattt ctggttgttt
    45481 tagtacattt ttaataaagt caataatata tgtattttgc tcatacggag gatgaactgt
    45541 ccctaattca attatgtctt ttgattccgt ttgatataat aatgtattac ttacatttac
    45601 atcagaagaa atgaatgttc cctttcccac ttttgcacat attagtccct tttcttcgca
    45661 aagtttaaat gctcgtgtta ttgtacttaa gtttaaatct agaaaatctg ctaattcccg
    45721 ttgtggaggc agtttatctc caggatttaa atttcctctt ttaatatctt cttctaataa
    45781 cattgctaaa gttttatata ttggtggttt tcggttatct aattttggtt tccatgtcat
    45841 aggatagttt tcaaaagaat ttattggcat ataattactc ctcttaatta taattgtact
    45901 ccatacaatt ttatcattgt atgcttctat tttagatgct atacttgtat ttgtaaatag
    45961 ctatttcaaa ataaataaat aagagaggta taatatgaag actataggct taattggtgg
    46021 tatgagttgg gaaagtacca ttacatatta tcaagttatt aatacagtaa taaaagaaag
    46081 attaggtgga ctacactctt ctaaatgtat actttacagt gtagattttc aagaaattga
    46141 agaatgccaa tctagtggaa attgggaaaa aagcgccaaa attttagctg atgctgcaat
    46201 taaattacaa gaggcagggg cagattttat tgttatctgt actaatacta tgcataaggt
    46261 atcagataaa atacaagaaa gtatacatat tccattactt cacatagcag atgtaactgc
    46321 tacggtatta agggaaaaag aaataaaaaa agtggcctta ttaggtacta aatatacaat
    46381 ggaacaagat ttttataaaa atgtaattat taataatgga attgaagtct taattccaaa
    46441 tgaagaagac cgtataatag taaatgacac aatatttaat gaactttgct taggaattat
    46501 atctgaatct tcaaaaaaag ctttcttatc tattatagat aagcttggca aacaaggtgc
    46561 agaggctgtt atattaggat gtacagaaat aggtctttta attaaacaaa atgacacttc
    46621 tattccacta tttgatacga cagtaataca tgcaatagaa gccgcactaa gttcaattta
    46681 agacaatatt gattaataaa aaaaatatct atagatttgt gtaaataaga ctttttataa
    46741 tttatattac tagagatttt aaacctatat attgtaacaa aaaaggatag tataattacc
    46801 ctatactatc ctttttctta atttaatatt taaataaact caacactttc aatttgtata
    46861 caaatctatc ttacatttat aacatcacta ttttgagagc tatttccatt ataatttgca
    46921 acaacataaa tatctagatt taaatctcct tcaggaatac ttatagtatg ctcatttccc
    46981 tgtatatcac tttgatatag agtaaattct ccatctccat tagtattatt ttttacatat
    47041 atactgtaag tacagtcctt atgagatata ctactccagt taactctaat gacattatta
    47101 tctctatcaa cattagctga tatattttct accctcatat ctttaatatt attatcatta
    47161 tttgaatttc catttccatt ggtaatattt attacattac ttggcttagt tgtatctgaa
    47221 tcctttttcc ctatgacata aatatcaaaa tctatatttt gattaccctt catatctact
    47281 tctatagttg catatacctt gttagactta cctaaatcac tttcatttat agttatagat
    47341 ttaattttct taaatgattc tcctgacaac ttatctttaa gatatatatc ataatcaaag
    47401 acatctttca tataatccca ttcaagttta ataataactt tattgtttac tattttatgt
    47461 gaaccaacca agttttgtat atagtcattc gttatagttt ctttgactac tgttactgtt
    47521 attactttag atttatctcc acaagttatt ctcaccctat ctttaccttc tctaagccct
    47581 acaacatttc cattactact taaacttatt gctctttcta caggtaattt tgaatctact
    47641 aactcataat atatttttgg tggttctaaa ccaggcggag aagttattat atctggtttc
    47701 aatttttcat tctggtcaac ttctattttt atatcatcca tatttatttc agcaactcta
    47761 gcttgaatcc taaatgttct ctcaatttct ttatttccac acttagcata tattgtagct
    47821 ttaccaactc caactgcact tactttattt cctttgattt ttaaaatatt ttcattgcta
    47881 ctcttataaa ctggcttata tgatttttta aacttatcat aatcaacttc tattgtactt
    47941 tctatagtag cactatcacc aacatgtttt aaatccccat taatctccat atctagtgat
    48001 tctacctctg ggtctactac ttttatagta gcctttttta atactcttga atttttcatg
    48061 atacccacag aagaataccc aacctttaat gctgtcattt tatttccatc tatttttaaa
    48121 gtccctgagt tatccaatac attaaaccaa atatttggat ttttagcata cgaaggaacc
    48181 ttaatatatt cacctgtaga caaagtaact gtttcattta attttactac atatttatct
    48241 atatctttaa catattcccc atctacaatt tcaatttcta ctccctttac cattggtcta
    48301 agtattccaa atttaaaaag gtagtactgc gcaacaagca atataggaat agatataatt
    48361 atggcaattt ttctgtattt cttatttttt acaaatatca tctatccact tccttttagc
    48421 ctaatatata atcatttgtt ttgtaagcaa tctacctaag ttaaatattg ggataaactg
    48481 gaaaattatt atatttcaga atatccctat actaattata aaccataaat ttaaaattta
    48541 aaactaaaat taatgttaat ttcttactat tacaatagtc taattttagt gaaataacat
    48601 ttgtcttgtc agctgaaaag ttatataatt aattaaaaag aaattatact tatattatat
    48661 gaggaggatt ttaaattgga aatcaattat aaaaaaagaa atttcaaatc atttgctaaa
    48721 agaaaaaata ttgaaatttc tgttcaaagg tatcttattg acgcactaag ttatatggca
    48781 ctcggtcttt tttcgtccct tttaattgga acaattttca atacattagg agataatttc
    48841 aatatttctc tttttactga agttataagc cctcttgcta aacaggttac tggtccagct
    48901 atagcagtgg ctattgcgta tggacttcaa gcacctccac ttgtactatt ttcttgtgca
    48961 cttgttggag cttgtggtaa tgaattagga ggacctgttg gagcatttgt cgctacactt
    49021 tttgctgtag aggttggaaa attagtttca aaagaaacaa aaatagatat attggttaca
    49081 cctgctgtaa caatactaat tggagtactt gtagctgaac ttattggtcc agctgtttct
    49141 gcttttatga cttcatttgg aaatataata atgcaagcta caactatgca acctataata
    49201 atgggagctt tagtctctgc acttgttgga atagctctta cattacctat aagtagtgca
    49261 gctatttgta tgatgttaag tttaggtggt cttgctggtg gtgcagcaac tgtaggttgt
    49321 tgttgccaaa tggtaggctt tgctgttatg agctttagag aaaatggagt tggtggcctt
    49381 gtggcacaag gtcttgggac atctatgttg caagtaccta atataataaa aaattggaaa
    49441 atttggatac cacctactgt agcttcaata ttacttggac cattatctac aacaatattc
    49501 aaaatggaga atattcctat tggttctggt atgggtactt gtggattggt tggacaattt
    49561 ggaacagtaa ctgctatgca aagtgctgga aaaggaggta tatctatgtg ggttggtata
    49621 cttttactta attttatact tcctgctatt gtaactttgt tgatttcaga atttatgaga
    49681 aaaaaaggtc taataaaacc tgaagattta aaactagatg tataaattaa aaactactcc
    49741 tttgacttat ataaaagtaa ggagtagttt tttttatgaa aattccaaca ttttttttaa
    49801 tagccaatcc atagaacctt taacttcatt ccaaatcact atgttttcat catagtaata
    49861 gacagcttct gccttttctt cctctgtaac aaattctcta ccaaaagcat ttcgccaatc
    49921 taacaaatat aatccaacgt acttattttt acttctagca accttaatag aatcatttgc
    49981 caaaaacata cttttatttt taaagtaata aagagcttta ctgtacatcc atgtagcaga
    50041 tttttcttct ttataaagtt caaataattt atttattgaa gttctatcat ttaatctaat
    50101 taatacattt aataatttgt atcttattcc ctgctcatca ctaggattaa tttctattaa
    50161 atattctaat acttttttgg actcctttag attattaata ctttctaact ttctagcaag
    50221 ggattcaagt gctatcatat aggctctggt agataaacct ttccaaaatc caagttcttt
    50281 atcttcttta gtaatcatac ttttacctat atttacagct tcctccatat atctaattga
    50341 ttcaatatca ctattcgcat cttgtgatag cttaatatat cttttatata gtattttctt
    50401 cttttctaaa tctaaatcta cagactttga tttggaatta gtctctttta cccaaaattc
    50461 tacattagaa atagctatag tatcttgatt taaaaagtca atactacaaa catcttttat
    50521 taaagacgat ttattattta tagtatttaa agaaacacct atttgttttg aaaactcttt
    50581 ttttgttata tgtagtggat gcttcttatt gtataaaaga ttttgttcta aaactatatt
    50641 tagtatagct gaagaccata tatcagctct agaagaatga attatctctt tattattatc
    50701 taaaaggttt tgcaaaattt taaagcttat atctttgtat tcttgattta aattggagtt
    50761 gcaaaatcta tttatcttgt ccttaatttc ttctatcttg cctgtcatga ctcctcctcc
    50821 atattttaca tatataaaac tagtgctaca aactcaagat cttcttctcc tatattttct
    50881 atagaatgtt tttcgccatc agctgtatac actacatcac cctcatttac ttctacaaat
    50941 tccccattat caaatacttt accttttccc tttagtatat aatatacttc aaaatctgtt
    51001 gtatggtcat gcacaccaat tgaacttcct actggtaaag ctactctttt aaatagtctt
    51061 ccttttcctt taagctcttc attttgtatt atgttttcaa gcttaacctt tcctatacca
    51121 ccatttaaat tttcttttac ttctacttgt aattcagatt tctttcttat catagctcat
    51181 cccacctgcc aaacaatcaa tctaactact aaattggcat atcctttcca taaatatgtt
    51241 tgtattttaa tataataata acatatatta tcataaaaaa atattactga atacacaaaa
    51301 atgatactat ttttacatat atttcgactt aattaaatta tcttacaagt tgacgtctat
    51361 atgaaaaaaa catatactca tatagtatgg taaaattttg ttaaactatt tatctggagg
    51421 ttctcgacat atgtcagttt taaaaacgca agaaaaactt aaacaaccta gagatttata
    51481 tttctgctgt tcaatattta cctttgtagg acttgcatac tatggtatga aattggtatt
    51541 attattgttt ttagctgaac aagtctccaa aggtggttta gggttaacac cagcagaatc
    51601 cgcatcaatg cttgcatctt ttttagcatg gacttatttc tctccagtta ttggtggatg
    51661 ggtcagtgat agatttttag gtcccaaaaa ctgtattata cttggaatgc taatggtttc
    51721 aattggttat tttctaggat acatagcaaa tagtaagatg gatataaaca tcatgatatt
    51781 tttatctgga ttaggaatag gtttttataa aggaaactta catactatgg ttggaaactt
    51841 atataccaat gatgacccaa gaaaagatgg agctttctct attacgtata tggctactaa
    51901 tctaggtact ttatttggcc ctttaatatg cggtttagtt gctaatgaat ggtttgctat
    51961 gaaaagcgga ttatctataa gtatgtatgg atatagatat gtatttttat tttcatcaat
    52021 tacggttcta ataggtttat tcttctttat atttggaaac agaaagtttt ataaaccttt
    52081 gaataatgac cctattaacg ggagagagtc tataagaaaa tcactagaat ataagaaaat
    52141 gctcgcttca agacctttaa ctttgattga gaaaaaaaga ataatagtaa tattggtgtt
    52201 agcttttttc acagtatttt tttggatagc atataaccaa gcctctatgt ctattgcact
    52261 ctatacaaag gaacacataa atcttactgt tggcaatttt caaattccta cttcatggat
    52321 agattcatac aatggtctcc tttgtgttat tcttggacct atctctgctt tagtatgggt
    52381 aaaattatct caaactaaaa aaggcgattt aagtgtgcca aaaaaaatga gcttaggttt
    52441 tatactatta gccatagcat ttttgtttat gatagtagca gttatacaaa caggaacaga
    52501 ccctaattca attcacaaag caagtgtatt ttgggtagtt ggatttttaa cattccaaag
    52561 tataggagaa atttgctttt ctccagtcgg gtatggtatg gtaaataaac tttcgcctga
    52621 aaagtatatt tcattcctaa tgggtgtttg gtttttaggc aaatttgcag caaataaatt
    52681 atctggctat acgcaagcta ttatagacca acttggtatg ttacaagtct tcatagtgat
    52741 accatcattt ttattgatat ttggaattat actacttata atgaataaaa aattagtaga
    52801 attatcaaat taaaaatttt ttaaagttaa taaaatatac aataaaaaat cgaggcatta
    52861 taatacctcg atttttattg tatctagtac aaactatata gctctagtgt aaacttttaa
    52921 ccattctctt tcttcatcag ttaagaaagg tgatatttta tcataaacta acttatgata
    52981 ccaatttaaa taatcttttt catccttatt cattaattct ggtgctatac catctaagtc
    53041 aataggagct aacgtaacaa cttcaaattc cataaattga ccatagaaat tcttttcagc
    53101 ttttctaact acaatttcat tctctgttct tataccatga gaaccttcta tatatatacc
    53161 tggttcatta gtagttacca ttccttcttc aagaactgca ctatcaaatc tttcaggtac
    53221 tactctccat ctaaatccat ttggagcttc gtgaacattt agcacaaatc ctataccatg
    53281 tccagttcca cattgataat caattcccat attccacatg caacttctag atagtatgtc
    53341 taagttatat cctctacaac catgcaagaa cttagcctta gaaagattta tcattcctct
    53401 tgctacagaa gtaaagtgta gttttaattc atcacttata ggtcctaaaa ctgtagtcct
    53461 agttatatca gtagttccat cataatattg tccacctgaa tctactaaaa ataatccttc
    53521 tgcctctaat ttataatttg actctggagt tgcactatag tgcatcattg cagcatgctc
    53581 tttatatgca gcaattgtat tgaaacttgg ctcaaagaaa ccttcttgct ctcttcttaa
    53641 gtcctctaat ttttgagtag cacttatttc agtgatttcc atcttaccta catttttctt
    53701 taaccagtac ataaatttag tgaaagctac accatctttt acatgtgaat ttcttatatt
    53761 ttctaattct acctcatttt tttgagcttt aaaaaacatt actggattga actcatcaac
    53821 tttctcaact tcacaaggta tattattgta aattgtataa ctaagcttag ttccatctaa
    53881 taaaactttt tcagttttgt ctatattttt tacaaattca tacacatcat tatatggctt
    53941 tatttgaaca ttttccttag ctagttcatt tagtatttct tcatttaact tactttcatc
    54001 aacaaataga taaacttctt ttaaagttat tactgcataa gaaagtacaa ctggattata
    54061 tttaacatct ccacctctta tattgaataa ccatgctata tcatcaagag tagttattac
    54121 atgagtagaa gtaccttttt cactcatttt ttctcttaat ctagctaatt ttgagctaaa
    54181 actttctcca caatatttaa catctaataa aaatgcttta ctatctgata aagcaggtct
    54241 atctggccat atactatcta ttaaatcata ctgatattct atctttatac cttttttaga
    54301 taatttttca gctaatgtag ctccttctct agcagatata actctaccat caaatcctaa
    54361 agttcctcct tcaggaatat ttttatataa atattcatct gtagttgggc aaccttcttg
    54421 tcccattttg aataatttta ttgtacttcc ttctaattga gattctgcct gtataaaata
    54481 tcttccatct gtccataacc cagcttcgtc tttagtcaca ataaccgtcc ctgctgaacc
    54541 attaaaccct gatataaatt ctcttgattt gaagtaatct cctacatatt cactttggtg
    54601 attatcagaa gatggaatca tataggcatc tatatttttt tcttccataa attttcttaa
    54661 tccacttaat ctatctttta tattcacaac aagacctcct cgaaataata gtttgaataa
    54721 ctaaatatat aagtatgtaa agtttattac ataaatattt tttgtataat ttatataaat
    54781 cttatacact ctaattatca caattataat tttaattata atatctattt gtgtaaagct
    54841 ttttttcata atcaaagagg aaattacatt taattttata tttaaatgta acttccttta
    54901 tttaaagtaa ttcatttatt tacaataatt cgtcatgaat tatttttctt ttgttagtaa
    54961 atccatagcc attaatcttg ttaatacatt tcttattccc aataatatta aaccaaatat
    55021 tattaaaact gttgctattc ctccaaatat ctgtaaaaaa ccaagtgtgg ctgtaaaacc
    55081 agcaatcttt cctgataata aacttgcaaa aaaacttgtt agataccagg ctcccataga
    55141 caacgtagca tacttagctg gagctaattt attgaacatt gcaagtccta taggagataa
    55201 gaataattca cctactgttg taaatatata agtcaatact ataaacaata tactagcctt
    55261 taccattcca tctggaccat tagctaatgt agcaaatacc ataactataa acccaacacc
    55321 cattattatc attcctaatc ccattttaac tggaatagag aaatcacctc ttttggtatg
    55381 agataattta acccataggg tagctaatac tgggcataaa gccacacata atatagcatt
    55441 tagtgatgta agccatgcta ctggcatttc aaatccaaat agagttctat ttacattatc
    55501 ccttacataa atcataaaag aactttgtgt ttgatagtat gctgtccaga ataagaccac
    55561 aaataaaaat aaaataacca ttgctattat cctatttttc tccaacttag taagtggtcc
    55621 atactcaatt ttttcacctt tattaccttt agtcacagga tattttccga cttcatttaa
    55681 taattttggt gcaagaagtg taaatataat catacctaac atcatgccta taccacaaat
    55741 taaaaatgcc atcttatatc cataagatac tatatctcca cttgctcctc ttactgcaaa
    55801 tacattatca gaaagcaatc cacatattat tggagctata aatgctccta catttactgc
    55861 catatagaat aaactgtatg ctgcatcttt tcttgacaca tcagttttag gatatatatc
    55921 cccaactata tttgagcaac ttgatttaaa aaaaccattt cctaaaataa ttattgatag
    55981 acctacccaa accattgcaa tagatgtaga tgaagcaaat agtacgaaat ctcctattgc
    56041 tattaaaagt gcacctatag aaatacattt ttgttgacct aaaactttat ctgctaacca
    56101 gccaccgact aatggtgtaa gatatataag acctgtaaat aagccaaaca tagatgttgc
    56161 ttcttgagta gaaagaccta aaccaccttg agctacactt gctgtaaaaa ataataccaa
    56221 taaagctgtt aaaccataat aactaaatct ttcccacaaa attgtcatgc aaataagcca
    56281 aaaactcttc ggatgaccac tttttttaga tacgctttct gtacttgaca taaaaaaacg
    56341 cccccttttg ttttatagtt aaatttaata ttaatattgc tttaaccatt ttagcacata
    56401 cttataatat catcttttct atgtttactc aatagattat agcctgtatt ttcatttttt
    56461 tattattatt tttaaaatta tgaaaaatat tattttttta gtatcttcag cagaaaatct
    56521 taatatatat atatttaaat aacaacttaa atcttcaatt cttttttgtt tattttttca
    56581 tttttgtaaa tttttattga aaaaattcaa attaaaaata tttcttttta ataccttttt
    56641 gcatgttatt tctttatcac ttcatatata taaatagatt ttattgcaaa ataataaaag
    56701 ctattttata ctctctatat tgagagtaaa aatagctttt atccatacag ttaatttttc
    56761 ttttttttaa taaattgact ttatctattc tttagctttc atttgatatt tatctgtaat
    56821 tttaacatta tatttttctt ttagattttg tataagtagg ttttgttttt ctgatgttaa
    56881 actgcttact aaatctgatt ttacctcttc aaatggctga tatttttcat cagttttctt
    56941 aattatatga tatccataat cactttctac aagtttgtta gatacctctc ccttcttcaa
    57001 tgcaaaggct gctttttcaa aagattccac catctgacct ttaccaaaga aacctaaatc
    57061 tccacctgat tctgcactac tatcttcaga gtatttttta gctagagtag caaaatcttc
    57121 cccagcttgg gcttttttaa gtatttcttc agcttctttc ttaagttcag cttttttgct
    57181 actactaact tgcttacctt tatcatcaac agtttttatt aaaatatgtg aagctctaac
    57241 ttgtaaataa ttgctcttgt ttttattgta atagttctct gcttctttat cagtaacttt
    57301 tgatttttca tttaaatatt ttgatgctac tagctctttt ttcatatcat cttttatata
    57361 tttttcagtc aaatcaaact gttttaaaaa ctcttcttta gtcattccca ttgctgattc
    57421 tatactactc attaaattat tatactgagc atctagttgg tcattagtta tacttatttt
    57481 ctcttttgct gcttcagagg ataatatatc agatgtaatc atagtttcaa tcatatttga
    57541 ttcatatgaa cgtatttcgt catcagtcat agtagttttt gcatttaaat aaaataatgg
    57601 ctccattctc tttcttaaca tttcacctgt tattttttta tccccaatag tagctactac
    57661 ctcactgcta ttatagtgtt ttgaagtagc aggcaatttt cttccagctt ctttgccaaa
    57721 aacatagcct ccacctaaac atatagctcc tactgcaaca attgctacaa tagctttaag
    57781 tgttttgttg tttagcttta tttccctttt tttaactttg ttatcagtat ttttttcatc
    57841 tgacacatca tcttttttag aatttacatt atctgaattt ttagattcat ctaatgtatt
    57901 ttcttttgga tttttttctt cagacattaa taccctcctt aattttaatt gtgcaatact
    57961 tcacctttat tattttacat taaaataata ttaaatgtgt gaatcagaaa tgaaactctt
    58021 atgaatttaa aatgaaatta aatacttctc aaactatacc ttataaagtt tcttcctact
    58081 tttgtatctc catattttaa catttgtata acttcattct tttccttttg caaataaatg
    58141 gcacattctt ctaaagactt aaatatttct aaaatgtcac cttttttatt tactaattca
    58201 acttttttct ttccacctct tttgattata gacttatatt ttttaaaata ttcatcatat
    58261 tcttcatcaa tacattcaaa tctataattc atttttaatg cttcaatttt atcatttgtc
    58321 aaaatttcat ttcttttttc attagaaagc cttatactaa atattttatt gtttagaata
    58381 ttaaatatct cagatggaga tttgctatta tcgagatagc tccattcact tttgcagtat
    58441 tcatctatat ttaatacttc acttaaataa tttattgcat ctccaaagta atccatatat
    58501 ccatatttta aattttctct tatgtaccct aatggaactt tgagtttttt actacactgt
    58561 atatgagtgt caaaaaccca ctcttcttta gtatacaagt ttatagcttt tatacttttt
    58621 cctcttttta ttttaatttc ttttatgtac tctaaatctt cttctgtcaa acattcactt
    58681 actttttttt cttcaataac atttttttct agattataat tttcattttg gtccagtcct
    58741 tcaaacttat ttaaacctat tttttcactt tcaacttgaa cttctttttt acataattct
    58801 atgtttttat cattaataat tgcttcttta tcatctaatt ttatggtatt ttcactaatt
    58861 aacaaatctt cttctattat tttttcttct atttcattgt catcatttac tactttagtt
    58921 aatatttgat tatcaatatt aactacaact ccttcttcat ctatcaactt ttcttcagat
    58981 aatatttttt cgttttttaa tattacttca ccttcttctt ttactgactc acttttttgt
    59041 ctttttttca caataccaaa ccactttttt aacactcaat gttcctccta atactttatt
    59101 actattctat actatcatat aaaatattac tgttctcata aatcacttaa ttttcatatg
    59161 tttttgatat gatactcccc atgtttaaag aaaagatatt caagtgaaaa agatgaccta
    59221 tttctagtag cccaacatga catcaaactt aagatatgca attactgttc ctaaactaat
    59281 ccatacatca atttaggcta gtagattttt actttctaca ccactatcaa aaaacttact
    59341 attatactta ggatacaata taacatttac ataaatagac tatattatca tttgatttgt
    59401 atttattgcc cataatggta ttatatatta attatttaca taatccaaca atttctatct
    59461 atcaccttat atcttatatg taaaaatata ttcaataata attataaata acaaaaatgg
    59521 atttaattaa tcatatagac cttgaaactc aacatgatta attaaatcca ttataat
//
LOCUS       DAEHWM010000244        16275 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.guided.098, whole genome shotgun sequence.
ACCESSION   DAEHWM010000244 DAEHWM010000000
VERSION     DAEHWM010000244.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 16275)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16275)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16275
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.guided.098"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            246..863
                     /locus_tag="KNP36_003856"
     CDS             246..863
                     /locus_tag="KNP36_003856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009902665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PepSY domain-containing protein"
                     /protein_id="HBF0875628.1"
                     /translation="MCKKTYLLVVSMLIAGLLTACSGSPTKDSGQAQDNTKKEANASN
                     NALKDEKNNENLMEQDFKVPYTDAINIFKDKYKDADIVDLSLERDLNKFVYTVEGVDD
                     NNEYKMKIDANTKDVLEDKTEKLDSEDLNGVARKEKLDLNDIMTPQQAMEIALKEQNG
                     IVKEWSLDKDLDVTFYKIRIDKDKNEYDIKVDSKKGTVLKVEKED"
     gene            971..3502
                     /locus_tag="KNP36_003857"
     CDS             971..3502
                     /locus_tag="KNP36_003857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003420250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HBF0875629.1"
                     /translation="MSLKSLKIKENLYWVGSLDPDLRVFDIIMYTPYGTTYNSYVLKG
                     TEKTVLFETVKDKHFDNYIERLNDLNIDFEKIDYIVVSHTEPDHAGSVEKLLDLAKNA
                     KVVASETAIKYLKEIVNKDFEYVAVTDGDTLSIGDKTLEFFSVPMLHWPDTIYTYIKE
                     DKTLVTCDSFGSHYSNDKIVNTLDENEEKDYLDALRYYYDCIMGPFKPSMVTAIEKIK
                     DLDIDTVCPGHGPVLTENPRKIIDLYYNWSVNEQIKLEKEVTICYVSAHGYTKIMAEA
                     IKAYIEKNSNYKVNLFDVIEHKQEDILAKIAVSQGVLFGTPTILGDALKPIWDILISL
                     NPVLHGGKVASVFGSYGWSGEGIENAMERISQLRMTAVKPFAVNFKPSNEEIDKLYSY
                     TGKFLDKLNSTFGSKKKTKKFKCVICNEVFEGDSAPSVCPVCGAKEDQFIEVEEDEVT
                     FRKDTDEYFVIVGNGAAGFYAADAIRKRNKTCKITMISNEDELTYYRPALSDGINEEL
                     GSDFYMEDKDWYDKNNIVVILGTNVDKLDEVNKTIIVNDGAIKFDKLVIATGSRNFIP
                     PIKGHDLENVFTLRNIKDLYSVKEALEKSKKVVVIGGGLLGLEAAWEFRLKGLEVVVV
                     EAMDSILSKQLDKEGSKILEQCVRDTGIDVRLGVAVDGIEGDGKAQKVVFKDGDSVDC
                     DMVVFSIGVRANTQMVQDTSVKIDRGIVVDKTLQTNVKDIYACGDVAQVGNISLAIWP
                     SSVEMGKIAGANASGDNLTFESEVYPVSLDAMNVKVFSIGNIQNFDKEISSKDEGQRI
                     YKKLFMKDGSLVGAILINDLSCTVKLIRLISEKGDFEDIMKADIL"
     gene            3936..4637
                     /locus_tag="KNP36_003858"
     CDS             3936..4637
                     /locus_tag="KNP36_003858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanG-Cd-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="HBF0875630.1"
                     /translation="MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIES
                     KNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITK
                     PFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
                     TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNP
                     KFIKTVWGVGYTIEK"
     gene            4687..5769
                     /locus_tag="KNP36_003859"
     CDS             4687..5769
                     /locus_tag="KNP36_003859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012816161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0875631.1"
                     /translation="MRTALMAFIAIIFIWILYSFILYGKFSIWIVSFFENAFRMEYKA
                     ALNLYQQIFRNSMELFMILAMVIVFFIIFRVYLNWFTKYFSEINQGIDSLIKEDVGEV
                     ALSPELLAIEKKINSIKHILEQRKFETQMAEQRKNELIVYLAHDLKTPLTSVIGYLTL
                     LRDESQISEELRKKYLSISLDKAERLEDLINEFFEITRFNLSNISLEYSTVSLTRMLE
                     QLTYEFKPTLMSKNLKYTLNVTPNMMIRCDVNKMQRVFDNLLRNAVYYSFEDTTIEIT
                     AVQEDDYIKLKFINHSNTIPEEKLERIFEQFYRLDTSRNSNSGRAGLGLAIAKEIVEL
                     HNGTITAHSENNIIIFKVIIPIVGNL"
     gene            6030..7130
                     /gene="vanG"
                     /locus_tag="KNP36_003860"
     CDS             6030..7130
                     /gene="vanG"
                     /locus_tag="KNP36_003860"
                     /EC_number="6.3.2.35"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418924.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-serine ligase VanG"
                     /protein_id="HBF0875632.1"
                     /translation="MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDIIPIGIT
                     REGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNRVKNGIIEFLIPDAVSQNHIPNS
                     AIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK
                     SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEE
                     LQVAVDLAFEHDNEVIIEENIDGFEVGCAVLGNDDLLVGRVDEIELSKGFFDYTEKYT
                     LKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLTPSGEIIFNEVNTIP
                     GFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK"
     gene            7127..7933
                     /locus_tag="KNP36_003861"
     CDS             7127..7933
                     /locus_tag="KNP36_003861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HBF0875633.1"
                     /translation="MMNNILLDKNKEDKMTNTILLTKDKVYDGNLILVNAFLPVKTSE
                     DIDLIPVDTRFPSILMKREATNILQNILKSICGINEIVPVSGYRTAEEQQDIYSSSLR
                     DNGKDFTKKFVALPNHSEHQTGLAIDLGLKKEVIDFICPEFPYNGICNEFRKAALHYG
                     FIERYQCKKEEITGISQEPWHFRYVGYPHSEIINKMNLALEEYIEYIKRFSYTNCLKI
                     EDKEKIIEIFYVPIHTKEEVRISIPEQCVYQISGNNKDGFIVTFWRNRKD"
     gene            7951..10089
                     /gene="vanT"
                     /locus_tag="KNP36_003862"
     CDS             7951..10089
                     /gene="vanT"
                     /locus_tag="KNP36_003862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_021418922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine racemase VanT catalytic subunit"
                     /protein_id="HBF0875634.1"
                     /translation="MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSII
                     ARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMN
                     NLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKRLGLKYSLVITIVIYVIGMFG
                     DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLI
                     GFLISFLLMLCEGMFLHKLGVQRHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSL
                     IIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIASIIIILILKPLKKD
                     LKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCA
                     NQIGVKAFAVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAI
                     SLNKQKYNIKSHIKIDTGMHRLGFDVNDVRSILKAFKLKYLDICGIFTHLCVSDSLKD
                     EDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIGIALYGI
                     LSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYA
                     DGIPRNLSCGKSYVIINGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSE
                     LSASEVANNSCSISNELLSRVGRRLNVIKK"
     gene            10403..11023
                     /locus_tag="KNP36_003863"
     CDS             10403..11023
                     /locus_tag="KNP36_003863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HBF0875635.1"
                     /translation="MQYIQELLDLTQNYWVLATIIGLLSAFIESFIPALPLVAIVTAN
                     AAIQGLFIGCLLSWIGSGLGTTSLFLLISRFNDSKLFNKLRNSKTEKAISWMDKQGFK
                     LLFIAYACPFMPGCLVTIASAFGKKDLKDFVPAMLAGKFVMFIVISYVASDIEGFITS
                     PLKIASFILLVFLSWKIGNRVNKNLENHNYDFHHKKHHNDKDDKMI"
     gene            complement(11189..11725)
                     /locus_tag="KNP36_003864"
     CDS             complement(11189..11725)
                     /locus_tag="KNP36_003864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009889535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent hydrolase"
                     /protein_id="HBF0875636.1"
                     /translation="MIKETHERGGYIFALLILPFINNLYLVKYDIAYKIVLIIIYIYF
                     AYLGSLFPDIDMRGSYISKKFMLIYKLFGSRFRHRGFTHSLIALLLIYSFFKSLTIFT
                     NNNIVFSCLSSGFIIGYLSHLCLDLITKEGIELFYPITINISLLPIKTNSKTEKFISK
                     LLNFIVIFLIGYQFYILL"
     gene            complement(11838..12512)
                     /locus_tag="KNP36_003865"
     CDS             complement(11838..12512)
                     /locus_tag="KNP36_003865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HBF0875637.1"
                     /translation="MSLFIISQCITSFAFTPENNKFKVKPLPYAYDALEPYIDKETMK
                     LHHDKHYQAYVDKLNAALEKYPELYNYSLCELLQNLDSLPKDIATTVRNNAGGAYNHK
                     FFFDIMTPEKTIPSESLKEAIDRDFGSFEKFKQEFQKSALDVFGSGWAWLVATKDGKL
                     SIMTTPNQDSPVSKNLTPIIGLDVWEHAYYLKYQNRRNEYIDNWFNVVNWNGALENYK
                     NLKSQD"
     gene            12715..14589
                     /gene="asnB"
                     /locus_tag="KNP36_003866"
     CDS             12715..14589
                     /gene="asnB"
                     /locus_tag="KNP36_003866"
                     /EC_number="6.3.5.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003436426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="HBF0875638.1"
                     /translation="MDGNISIYYKGDISKKEDIKFKIKESVNNTRLSSRIEYKDEEKT
                     FDFERFNVIDAIYGNKPFEKDGKVIVFNGNIYNYHEIKEELIKKGHNFTTNDDIEVLL
                     ASYIEFGKNCVHKIKGMFNFIIYDRENESIFGARDLFGIKPLYYINKENAIIFSSEYK
                     FLLEYMKNLNINERSLQSYFSFQYVLPEDTMIQGIRLIPAGHYFRVENGILSLKRYNK
                     LEFRSSTKFFYTKNHLGNRDVNEDDIRNIVVDSIVTHMEEEKEIGTFLSGGIDSSIIT
                     TVASQINPNIKSFSAGFSVKGYSELEVAKKTADKLGIENIQINITQDEYIKSLPNVIY
                     SLDDPIADPSEVGLYFLIKEAGKHVKVALSGEGADELFGGYNIYKEYSTMKSVVNSPT
                     YIKSILGRVSELMPNIKGRNYLYRATTPLEKRYIGNAKVFENSEVKRFFFKYKEKNIY
                     EYLLSNLYRDAQKNNYDYISKMQHIDVNTWLQGDILQKISKLSTAEQVELRVPFLYKD
                     VFDVAKNLRMEQKINKNNTKVLLREAFREIVPEHVVQRKKLGFPTPIRVWLKDSLGDI
                     VKETIYNSNVDEFIDKKYAIKLLDTHLKGHRDNSRKIWTIFTFCLWHQLFIEHKNVEY
                     "
     gene            complement(14681..16117)
                     /locus_tag="KNP36_003867"
     CDS             complement(14681..16117)
                     /locus_tag="KNP36_003867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trypsin-like peptidase domain-containing
                     protein"
                     /protein_id="HBF0875639.1"
                     /translation="MICTIKPLKISIKKSTEPLIEFISDTTYKNKSSSYIKEVYFTRY
                     IGVDDSIDKYIEKIKNIDTYFFNNPTIPYIRLNNLKINFDKEQTDKMLKIFNIYNSSK
                     FNSWDLYNIDFPCKIENDTLNWTKKIAFKNTLDLFSTSMPNCTSSIIKNFAVKLLCWI
                     DYFLPKLFYNKVKTTISPKIVYFGNIKRQELFFLYFLSQLGCDILYINPNKDILDLYP
                     ECSKFSTLFELSRKTPNILEIPFERHITNINYSENTNKTSPTTNKPNSKNTLNNTNLT
                     SKKIVQDEEVELSYEDLAKLSASVVMIVVCNNENKPFKSGSGVVINNEGYILTNLHVV
                     NDGYSFLVRFENDDKVYTSYQIIKYHSDYDLAVIKVDRKCKPIPVKVSKKPVRGQKIV
                     AIGSPLGLFNTVSDGIISAFRDFETVQMIQFTAPISSGSSGGALLDMFGNLLGLISAG
                     YDDGQNLNLAVESSLVKIFANNFIEIVN"
BASE COUNT         6209 a         1774 c         2723 g         5569 t
ORIGIN      
        1 caaaatgaac tttttagttc atgaggcact ctttttgtac gaaataaaat atatttttat
       61 tatttcaaca atgaaaaaga ggcttgtttc cattttgaga cagtataatt tttatgtaac
      121 tttaatttta gtaaatataa agttttaaaa ttgataaaat aggaggaatt tttaatataa
      181 aagggtaaat aaagggttta gagggcataa tatagaataa attaatatat ttaaggaggg
      241 tttttatgtg taaaaaaacg tatttattag tggtaagtat gcttatagcg ggtttattaa
      301 ctgcatgtag tgggagtcca actaaggatt caggacaagc acaagataat acaaaaaagg
      361 aggcaaatgc atcaaataac gctttaaaag atgaaaaaaa taatgaaaat ttaatggaac
      421 aagattttaa agtgccatac acagatgcaa taaacatatt taaagataaa tataaggatg
      481 ctgatatagt agatttaagt cttgagagag atttaaataa atttgtttat actgtggaag
      541 gtgtagatga taataatgaa tataagatga aaattgatgc taatacaaaa gatgtattag
      601 aagataaaac agaaaagttg gattcagaag atttaaatgg agttgctaga aaagaaaaat
      661 tagatttaaa tgacataatg acacctcaac aagctatgga aattgcatta aaagaacaaa
      721 atggaatagt taaagaatgg agtttagaca aagatttaga tgttactttt tataaaataa
      781 gaatagataa agataaaaat gaatatgaca taaaagtaga ttctaaaaag ggaactgtat
      841 tgaaggtaga aaaagaagat tagaagattt aaactatctt taaaataatt tcttttttga
      901 ataaattttg tttaaaatat aacaagcagg gtataaagag actaaataac tattttagga
      961 ggagtacggt atgtcattga aatcactaaa aataaaagaa aatttatatt gggtaggttc
     1021 gcttgaccct gatttaagag tatttgacat aattatgtat acaccttatg gaactactta
     1081 taattcatat gtattaaaag gaacagaaaa aacagtttta tttgagacag ttaaagataa
     1141 gcattttgac aattatattg aaagattaaa tgatttaaat atagattttg aaaaaataga
     1201 ctatattgtt gtaagtcata ctgaaccaga ccatgcagga agcgttgaaa agcttttgga
     1261 tttagctaaa aatgcaaaag tagtagcttc agaaacagca attaaatatc ttaaggaaat
     1321 cgtaaacaaa gactttgaat atgttgcagt tacagatgga gatacattat caattgggga
     1381 caaaacttta gaatttttct ctgtacctat gcttcattgg ccagatacca tatacacata
     1441 tataaaagag gataaaactc ttgtaacatg tgattcattt ggtagtcact atagtaatga
     1501 taagatagta aatacacttg atgaaaatga agaaaaggat tacttggatg ctttaagata
     1561 ctattatgat tgtataatgg gtccatttaa accatctatg gtaactgcta tagaaaagat
     1621 aaaagattta gatatagata ctgtatgtcc aggtcatggt ccagtattaa ctgaaaatcc
     1681 tagaaaaatt atagaccttt attacaactg gagtgtaaat gaacaaataa agttagaaaa
     1741 agaagttaca atttgttatg tttctgcaca tggatataca aagattatgg cagaagctat
     1801 aaaagcatat attgaaaaaa atagcaacta taaagtaaat ttatttgatg taatagagca
     1861 taagcaagaa gatattttgg caaaaatagc agtatcacaa ggtgtattat ttggaacacc
     1921 aacaatatta ggagatgcgt taaagcctat atgggatata ttaatatcgt taaacccagt
     1981 tcttcatggt ggaaaagttg cttcagtatt tggttcatat ggatggagtg gagaaggtat
     2041 agaaaatgct atggagagaa taagtcagct tagaatgaca gcagtaaaac cttttgctgt
     2101 taactttaaa ccatcaaatg aagagattga taaattatat tcttatacag gtaaattcct
     2161 agataagtta aattctactt ttggaagtaa aaagaaaact aagaaattta aatgtgtaat
     2221 ttgtaatgaa gtttttgaag gtgatagtgc tcctagtgta tgccctgtat gtggagctaa
     2281 ggaagaccaa tttatagaag ttgaagaaga tgaagttact tttagaaaag atactgatga
     2341 atatttcgta atagtaggaa atggagcagc tggtttttat gcagcagatg ctataagaaa
     2401 aagaaataaa acttgtaaga taactatgat ttctaatgaa gatgagttga cttactatag
     2461 acctgcactt tctgatggta taaatgaaga acttggttca gatttctaca tggaagataa
     2521 agattggtat gataaaaata atatagtagt aatattagga acgaatgtag ataaattaga
     2581 tgaagtgaat aaaactatta tagtgaatga tggagctatt aaatttgata agcttgtaat
     2641 agctacagga agtagaaact ttataccacc aattaagggc catgatttag aaaatgtgtt
     2701 tactcttaga aatataaaag atttatatag tgtaaaagaa gcactagaaa aatctaagaa
     2761 agttgtagtg attggtggcg gtttattggg acttgaagct gcatgggaat ttagactaaa
     2821 aggattagaa gtagtagtag ttgaagccat ggatagcata ctatcaaaac aacttgataa
     2881 agaaggtagt aaaatattag aacaatgtgt aagagataca ggaatagatg taagattggg
     2941 tgtagcagtt gatggtattg aaggtgatgg aaaagctcaa aaagttgtat ttaaagatgg
     3001 agatagtgtc gactgtgata tggtagtatt ttcaattggt gtaagagcaa acactcaaat
     3061 ggttcaggat acatctgtaa aaattgatag aggtattgtt gtagataaga cattacagac
     3121 aaatgttaaa gatatatatg cttgtggaga tgttgcacaa gtgggaaata ttagtttagc
     3181 aatatggcca tcttcagtag aaatgggaaa aatagcaggg gcaaatgcaa gtggagataa
     3241 tttgacattt gaaagtgaag tatatccagt ttcattagat gcaatgaatg taaaagtatt
     3301 tagtattggt aatatacaaa attttgataa agaaatttca tcaaaagatg aaggtcaaag
     3361 aatatataaa aaattattta tgaaagatgg ttcattagtt ggagctatac ttataaatga
     3421 tttaagctgt actgttaaat tgataagatt aatatctgaa aaaggtgatt ttgaggatat
     3481 tatgaaggct gatatactat aatttaaata cattaaaata aaaaggagtt gtctcaaaat
     3541 tgattttttt ctaatcaaat tttaaattca actccttttt tgaattttta tataaaataa
     3601 catggaaatt ttagtaatgt ctgtggttac atacataggt ttaattgttt tttatatgga
     3661 ttgtctctgg tataataaat tgaattgtgt ttgactgata gatattttta ttgaaagtta
     3721 atacctgtta tgcgataata aggacgtgtt aggggagttt ttataataac aattaatctc
     3781 agtttttgtg ttccaatagt agcatcaaca cattctgatg tagtagttct tttcttataa
     3841 aaattagtta caaatatgct tgtaattatt tgatatgtaa atttaccaat attataaatg
     3901 atgacctcga taataaggag agtgaaaaat aatctatgaa cgaaaatatt ttgattgtgg
     3961 atgatgaaaa agaaatagca gatttaattg aagtatattt aaaaaatgaa ggttttacag
     4021 tatacaagtt ttatacaggt aaggaagctc tagaatgtat tgaatctaaa aatttggata
     4081 tggctatttt agatattatg cttcctgata ttgatggatt tcatatttgc cagaaaattc
     4141 gagaaaaata ctattatcct atcattatgt taacagctaa aattgaagat atagacaaga
     4201 taatgggttt aaccataggt gctgatgatt atataacaaa gccatttaac cctttggaag
     4261 ttgttgcaag agtaaagaca caattaagaa gatatatgcg atataataat tcttatgaac
     4321 aacagtcgat aattgttaat gagtatgata ttaaaggatt gattatcaat aaagaaacac
     4381 ataaatgtag tttatttggg aaagaagtag cattaacacc gattgaattt tctattcttt
     4441 ggtatttatg tgaacatcaa ggaaaagtgg ttccttctga agaattgttt gaagctgtat
     4501 ggggagaaaa atatcttgat aataataaca cagttatggc tcatataggg cgattacgtg
     4561 aaaaaattca tgaaccttct aaaaacccga aatttataaa aactgtatgg ggagtaggtt
     4621 atacaattga aaagtaaaaa tattaaagtc aatcctgact ttactcaagt gagaaataaa
     4681 atttttatga gaacagcttt aatggcattt atagccatta ttttcatatg gattttatat
     4741 tcttttatat tgtatggtaa gttttctatc tggatagtat cattctttga aaatgctttt
     4801 cgtatggaat ataaagctgc attgaattta tatcagcaga ttttccgtaa tagcatggag
     4861 ctcttcatga tactagctat ggtgattgtg ttttttataa tattccgggt ttatttaaat
     4921 tggtttacaa aatattttag tgaaataaat caaggtattg actctcttat caaagaagat
     4981 gttggagaag tggctttatc tccagagtta ttggcaatag aaaagaaaat aaactcaatt
     5041 aaacatatac ttgaacaacg taaatttgag acacaaatgg cagaacaacg taagaatgaa
     5101 cttattgttt atcttgcaca tgatttaaaa acaccactta catcagttat agggtatctg
     5161 acactacttc gagatgaaag tcagatttct gaagaactgc gaaaaaaata tttatctatt
     5221 tcgttggata aggcagagcg tcttgaagat ttaattaatg aattctttga aattacaagg
     5281 tttaatttat caaatatatc acttgaatac agtacagtaa gcttaactcg tatgcttgaa
     5341 caactaacat atgagtttaa acctactttg atgagtaaga atttaaaata tacactgaat
     5401 gttacaccaa atatgatgat aaggtgtgat gttaataaaa tgcaacgtgt atttgataac
     5461 ttattacgaa atgctgttta ttatagtttt gaagatacta ctattgaaat aacagctgta
     5521 caggaggatg attatataaa gcttaaattt ataaatcata gcaatacgat tccagaggaa
     5581 aaacttgagc gtatttttga acaattttac aggttggata catctcgtaa ttcaaacagt
     5641 ggtagagctg ggttgggact tgctatagct aaagaaatag tggagcttca taacgggaca
     5701 ataacagctc atagcgagaa caatataatt atctttaagg ttattattcc gattgtagga
     5761 aatttgtaag aatttaagta taaaaaaata ggaaattctt taggataaat aaataaagag
     5821 cactcttgtt attgatataa ttactgtatc aaaacaagag tgcttttatt ttgatacagt
     5881 aattatatca atagaaaaat gtgaaaatat attatgtgga acagatgcaa ttgtaagtga
     5941 aggttgattg gatttgaaat agaaaaagta ttttaacatg tttctgtaga ttgtataaaa
     6001 ataaataaat caacaaagga gaatcaaaga tgaataataa aaaaattgca gttatatttg
     6061 gtggaaactc aacagaatat gatgtatcat tacaatcagc ttttgcagta cttgagaatt
     6121 tgaatacgga aaaatatgat attataccaa ttggaattac aagggagggt aattggtatc
     6181 attatattgg agattataat aatatccaga ataacacttg gtttgaaagg gatactgata
     6241 taattccagt tattgtttcg cagaaccgtg tcaaaaatgg tattattgaa tttttaattc
     6301 ctgatgctgt ttctcagaat catattccaa atagtgctat tgaatcatgt gaaaatgata
     6361 ttaaatacac taaacttgat tttgtgtttc ctgtactgca tggaaaaaat ggagaagatg
     6421 gaacagtgca ggggttattt gaattggcag gtatacaggt tataggatgt ggtactcttt
     6481 cttcagcatt atgtatggac aaagacaaat cacataaact tgttcattca gaaggtatta
     6541 aagtaccaaa atcaatatta ctaaaatact cagataaatt taatgtggct gaactgtcaa
     6601 aagacttaac ttatccatta tttataaaac ctgtgcgtgc aggttcatca tttggtatta
     6661 gtaaaattta taaaaaagaa gagttacaag tagcagtaga cttggctttt gaacatgata
     6721 atgaagtaat aattgaggaa aatattgatg gttttgaggt agggtgtgca gttttaggaa
     6781 acgatgactt acttgttgga agagtagatg aaatagaatt gtcaaaagga ttttttgatt
     6841 atacagaaaa atatacattg aaaagttcaa aaattcatat gccagctaga attgatttgg
     6901 attgtgagaa aagaatacaa gagacagcaa aaattattta tagaactctt ggatgttctg
     6961 gatttgctag agtagatatg tttttaactc catctggtga aattattttt aatgaagtca
     7021 atacaattcc tggctttact tctcatagtc gttatccaaa tatgatgaaa ggtattggat
     7081 tgtcttttga agaaatattg gacaagataa ttgaggtgta cataaaatga tgaataatat
     7141 tttattagat aaaaataaag aagataaaat gacaaatact atcttattga ctaaagataa
     7201 agtttatgat gggaatctaa ttctagtaaa tgctttttta ccagttaaaa catctgaaga
     7261 tatagattta attcctgtag atacaaggtt tccaagtatt cttatgaaac gtgaagctac
     7321 aaacatttta caaaatattt taaaaagtat atgtggaata aatgaaatag tacctgtaag
     7381 tggatatcgt actgcagagg aacaacaaga tatatattca agttctctgc gtgacaatgg
     7441 aaaagacttt actaaaaagt ttgtagcact tccaaatcac agtgaacatc agacagggct
     7501 tgctattgat ttagggttaa agaaagaagt tatagatttt atctgccctg aatttcctta
     7561 taatggtatt tgtaatgagt ttcgtaaggc agcactacat tatggtttta tagagcgtta
     7621 tcagtgtaaa aaagaagaaa taacaggaat atctcaagaa ccatggcatt ttcgttatgt
     7681 gggatatccg cattctgaga ttatcaataa aatgaatctc gctcttgaag aatatataga
     7741 atatattaag agattttcgt atacaaattg tttaaaaata gaagataaag aaaaaattat
     7801 agaaatcttt tatgtgccta ttcatactaa agaagaagtg agaatctcta tacctgaaca
     7861 atgtgtatat caaatatcgg gtaacaataa ggatggtttt attgtgacat tttggagaaa
     7921 tagaaaggac taagaaatgg aggaacaaga atgattagga ataaatctta tgcagggctt
     7981 gattatttta ggattatagc tgcattactt ataattgcaa ttcatacatc tccattatta
     8041 tcatatagta aaatggctga ctttgtgtta actagtataa ttgctcgtat tgctgtgcca
     8101 ttctttttta tgctatcagg cttttttcta atttcaacat ataattataa ttgtaataaa
     8161 ctgaaatctt ttctaaaaaa tgtattattt atttacggga tagctattgt aatttatatt
     8221 cccttaaata tttacactgg atatttttcc atgaataatt tagtgcccaa tattattaag
     8281 gacattgtat ttgatgggac tttatatcat ttatggtatc tacctgcatc aattattggt
     8341 gcaagtattg catactttct tgtaaaaaga ctaggtttaa agtactcact agtaatcact
     8401 attgttattt atgtaattgg tatgtttggt gatagttatt atggtttttt agaaaaaata
     8461 ccactattaa agaatttata tgggtatatt tttgaagtat cagattatac acgaaatggt
     8521 atattttttg cacctgtatt tttcatactt ggtggaataa tatctaataa atctaattat
     8581 atgtcaacta aaaatagctt gattggattt cttatatcat tcttacttat gttatgtgag
     8641 ggaatgtttt tacataaact aggggtacag cgtcatgata gcatgtatat tatgttattg
     8701 ccatgtatgt atttcttatt tacagcctta acatttttga aaggttctcg agctaggtta
     8761 ttgcgaacat catcattaat tatttatatt atacatccta tgatgattgt tgttattcgt
     8821 atgttttcta aaatattcgg aatacaaact gtcttggttg acaatagcct tattcattat
     8881 atagtggtaa gtatagcatc ttttatagct tctataatta ttatattgat tcttaaacct
     8941 ctaaaaaaag acttgaaagg agaacataag gtaaatacca atagagcttg gattgaaatt
     9001 gatttaaata atttggaaca taatgtaaag atgatacaaa aagctatgcc agaagattgt
     9061 gaattgatgg cagttgtaaa agctaatgcc tatggtcata gtgcttttga agtagcgact
     9121 tgtgcaaacc aaataggtgt aaaagcattt gcagtagcaa caatagatga ggggattgat
     9181 ttacgtcgat atggaatact aggagaaata ttgattcttg gatatactaa cccaataagg
     9241 gcaaaggaac ttcataaata caatcttaca cagagtgtta ttgaccttaa tcatgctatc
     9301 tctttaaaca aacagaaata caacataaaa tcacacatta aaattgatac aggtatgcac
     9361 agactgggtt ttgatgttaa tgatgtgagg tcaattttaa aggcatttaa attaaaatac
     9421 ttagatatat gtggcatatt tacacacttg tgtgtttcag atagtctgaa agatgaagat
     9481 gtagacttta caaataaaca aattgaatgt ttttataagt taattgattt tctgttaaaa
     9541 aaaggtataa aaattcctaa agtacatatt caaagtagtt atggtttttt taattatccc
     9601 aatcttaagt gtaattatgt aagaattgga attgcattat acgggatatt aagttctcca
     9661 aatgatacga ctaaattgca acttgattta cgacctgttt tatccttaaa atcacaagta
     9721 attcttatta gaaaaataca aaaagatgat agttttggat atggaagagt ctttattgca
     9781 agcagagata gcgtaattgc tatattatct attggctatg ccgatggtat acctagaaat
     9841 ttatcctgtg gaaaaagtta cgtaataata aatggttgta gagcagcaat agtgggtcga
     9901 atttgcatgg accaacttgc tgttgatatt acagatatac ctaatgtaga agttggtaat
     9961 acggcaataa taataggaag agataattta tctgaattat ctgcttctga agttgcaaat
    10021 aactcatgta gtatatcgaa tgaattattg agcagagtag gaagaaggtt aaatgttata
    10081 aagaagtaac tcaattaaat agtaatattt gttgtactgt gtaatttatt ttactctgac
    10141 tagacatttt tagtaatatt atgtctaata tatatttttt ataacttaca tgacaattta
    10201 agttataaaa aggtgatgtt tcagattttt attttgaaac atcacctttt ttgttataat
    10261 atataataaa ataattatac cttaactgta aacttatata gattatttac tttttaatat
    10321 tagattcatt ttttgagatt ggtatataat aaacatatag agtatataat aatagttaaa
    10381 gttaaaaaag gggaaaagca atatgcagta tatacaagaa ctacttgatt tgactcaaaa
    10441 ttattgggtg ttagccacaa taatcggctt attaagtgca tttatagaaa gctttatacc
    10501 agccttacca cttgttgcta tagttacagc aaatgctgca atacaaggat tatttattgg
    10561 atgtttgtta tcatggattg gctcaggact tgggacaact tcattattct tattaataag
    10621 cagatttaat gatagtaagc tttttaataa gttgagaaat agtaaaactg aaaaagcaat
    10681 aagttggatg gataaacagg gatttaagtt attatttata gcgtatgcct gtccatttat
    10741 gcccggttgt ttagttacta tcgcatcagc ttttggtaaa aaagatttaa aagattttgt
    10801 gccagcaatg ttggcaggaa aatttgtaat gtttatagtt ataagttacg tggcaagtga
    10861 tatagaaggt tttataacaa gtcctttaaa gatagcatca tttatattat tggtgttttt
    10921 gtcatggaag attggaaata gagtaaataa aaatcttgaa aatcataatt atgatttcca
    10981 tcataaaaaa catcacaatg ataaagatga taaaatgatt tagcttgtac gaaataaaac
    11041 gtatcttaaa atgatttagt actaaattat tttaagatac gttttatttt ttgtattaag
    11101 gtacaaaatt tttagttctt ttgtaaacta aaatatataa aacttattta tacttagttc
    11161 aaaatattgt tatttatttt ttctacaact ataataaaat ataaaattga tatccaatca
    11221 aaaaaataac tatgaaattt aatagcttag atatgaattt ttctgttttt gagttagttt
    11281 ttataggtag taaagaaatg tttatggtaa tgggataaaa caattcaata ccttctttag
    11341 taataaggtc aagacacaag tgagatagat atcctattat aaacccactg gacaaacatg
    11401 agaaaactat attattgtta gtgaagattg tcagagattt aaaaaaacta taaataagta
    11461 ataaggcaat tagactgtga gtaaaccctc tatgtctaaa cctacttcca aataatttgt
    11521 atattaacat aaatttttta cttatgtaag aacctctcat atctatatct ggaaataaag
    11581 aacctaaata tgcaaaataa atataaatta taattaatac tattttatat gcaatatcgt
    11641 atttaactag gtatagattg tttataaagg ggagtatcaa aagtgcgaat atataacctc
    11701 ccctttcatg tgtttctttt atcatataaa aatcctcctg aatcgtcact ataaacatta
    11761 tattggtaaa tttagactat cttttattat attatatagc aaacataagt ttttttcaaa
    11821 aggattttaa tatttaatta atcttgagat tttaaatttt tgtaattttc taaagcacca
    11881 ttccaattta ctacattaaa ccagttgtca atgtattcat ttcttctatt ttgatatttt
    11941 aaatagtaag catgctccca aacatcaagt cctattatag gagttaggtt tttacttaca
    12001 gggctatcct gatttggagt agtcataata gataatttgc catctttagt agctacaagc
    12061 caagcccaac cagaaccaaa gacatctaaa gcagattttt ggaactcttg cttaaatttt
    12121 tcaaaagaac caaagtctct atcaatagct tcttttaaag attcagaagg tatggttttt
    12181 tctggcgtca ttatatcaaa aaagaattta tgattataag ctccacctgc attatttctt
    12241 acagttgtag caatatcttt aggtaaagaa tctaaatttt gcaataattc acataaagaa
    12301 taattataaa gctcaggata tttttcaaga gcagcattta atttatcaac ataagcttga
    12361 taatgcttat catgatgcag tttcattgtt tctttatcta tataaggttc aagtgcatca
    12421 tatgcataag gtaatggttt aaccttaaat ttgttatttt caggtgtaaa agcaaatgaa
    12481 gttatgcact gtgagattat aaataaagac ataataactg gtattaatat ttttttcttc
    12541 ataaaaatca cctcctaata tagtatttct agaaataaaa aaaatatgaa atattaacag
    12601 ataatttata agaatttaat agcaatttca ttttaaattg aataagtttt aaagccaaag
    12661 acaaaactat gaaatataga ataagactaa aggacagaaa ggaattttga ttatatggac
    12721 ggcaatattt caatttatta taaaggtgat atatctaaaa aagaagatat taaatttaaa
    12781 ataaaagaat ctgtaaataa tacaagactt tctagtagaa tagagtataa ggatgaggaa
    12841 aaaacttttg attttgaaag atttaatgta attgatgcta tttatggaaa taaaccattt
    12901 gaaaaagatg gaaaagttat tgtttttaat ggaaatatat ataactatca tgaaataaaa
    12961 gaagaattaa ttaaaaaagg acacaatttt actacaaatg atgatattga agtcttatta
    13021 gcatcttata tagaatttgg taagaattgt gtacataaga ttaaaggaat gttcaacttt
    13081 ataatctatg atagagaaaa tgaaagtata tttggagcaa gagatttatt tgggataaaa
    13141 ccactttatt atataaataa ggaaaatgca ataatttttt cctcagagta taagttttta
    13201 cttgaatata tgaaaaattt aaatataaat gaaagaagct tacaaagtta tttttcattt
    13261 caatatgtac ttcctgaaga tactatgata caaggaataa ggctgatacc agcaggtcac
    13321 tattttaggg tagaaaatgg tatactatct ttaaagagat ataataaact tgagtttaga
    13381 agtagtacaa aattttttta tactaaaaat cacttaggca atagagatgt gaatgaggat
    13441 gatataagaa atatagtagt agattcaata gtaactcata tggaagagga gaaagaaatt
    13501 ggaacatttt tgtctggtgg aatagattca tctattataa ctactgtggc ttcacaaatt
    13561 aatccaaata taaaatcttt ttctgcaggc tttagtgtca aaggatatag tgaattagaa
    13621 gtagcaaaga aaacagctga taagttaggt atagaaaata tccagattaa tataacacaa
    13681 gatgaatata taaaatcatt accgaatgta atttattctt tggatgaccc tatagcagac
    13741 ccttcagaag taggtcttta tttcttaatt aaagaggcag gtaaacatgt taaagtagca
    13801 ttgtctggag aaggagcaga tgaattattt ggaggatata atatatataa agagtatagt
    13861 actatgaaat cagttgtcaa ttcacctact tatattaaaa gtatattagg aagagtttca
    13921 gaacttatgc caaacataaa aggaagaaat tatctttata gagctacaac accattagaa
    13981 aaaagatata taggaaatgc aaaagttttt gaaaacagcg aagtaaaaag attctttttt
    14041 aagtataagg aaaagaatat atatgaatac ctgttgtcta atttgtatag agatgcacaa
    14101 aaaaataatt acgattatat aagtaaaatg caacatatag atgtgaatac atggcttcaa
    14161 ggcgatatac ttcaaaaaat tagcaaactt tctacagctg agcaggttga acttagagta
    14221 ccatttttat ataaagatgt atttgatgtc gcaaaaaatt taagaatgga gcaaaaaata
    14281 aataagaata atacaaaagt tttacttaga gaggcgttta gagaaatagt cccagaacat
    14341 gttgttcaaa ggaaaaaatt aggatttcca actccaataa gagtttggtt aaaagattct
    14401 ctaggggata ttgtaaagga aactatttat aattcaaatg tagatgaatt tatagataaa
    14461 aaatatgcaa taaaactttt agatacgcat cttaaaggtc atagagataa ttcgagaaaa
    14521 atatggacta tatttacatt ttgtctatgg catcaattat ttattgagca taaaaatgtc
    14581 gagtattaat acttttttca atattaatca gagggcaaaa gcatgcaatg ttttcaccct
    14641 cttgattatt atggaatagg ataagtagaa ttttgattga ttagtttact atctcaataa
    14701 aattattggc aaatattttg acaagactac tttcaacagc taaatttaag ttttgtccat
    14761 catcatatcc agcggaaatc aatcctagta agtttccaaa catatctaaa agagctcctc
    14821 ctgaactacc actagagatt ggagctgtaa attgtatcat ttgaaccgtt tcaaaatcac
    14881 gaaaagctga aataattcca tctgaaactg tattaaaaag acctagaggg cttccaattg
    14941 caactatttt ttgacctctc acaggttttt tactgacttt aacaggtatt ggcttgcatt
    15001 ttctatcaac ctttatcaca gctaaatcat aatctgaatg gtattttata atttggtaag
    15061 atgtataaac tttatcatca ttttcaaatc taactaaaaa tgaataccca tcattgacta
    15121 catgaagatt cgtaagtata taaccttcat tatttattac tactccagaa ccgctcttaa
    15181 acggtttatt ttcgttattg cacacaacaa tcataacaac agaagctgat aactttgcaa
    15241 ggtcttcata agaaagttct acttcctcat cttgtacaat ttttttagat gttagatttg
    15301 tgttattaag tgtattttta gagttaggtt tattcgtagt aggagaagtc ttattggtat
    15361 tttcactgta atttatattt gtaatatgcc tttcaaaagg tatttctaat atatttggag
    15421 tcttcctaga aagttcaaat agagtagaaa attttgaaca ttcaggatat aaatcaagaa
    15481 tatctttatt tggatttata tataaaatat cacacccaag ttgtgataaa aaatataaga
    15541 aaaaaagttc ttgcctttta atatttccaa agtatactat ctttggtgaa atagtagtct
    15601 tcaccttgtt ataaaataat ttaggtagaa aatagtctat ccaacacaaa agtttaactg
    15661 caaagttttt gatgatagag gatgtacaat ttggcatact tgtggaaaat aaatctaaag
    15721 tatttttaaa tgcaatcttt ttagtccaat ttaaggtgtc attttctatt ttacatggaa
    15781 agtcgatatt atataaatcc caactgttaa acttagaact attataaata ttaaaaattt
    15841 taagcatctt atctgtttgt tctttgtcaa aatttatttt tagattgttt aatctaatat
    15901 agggaattgt aggattatta aaaaaataag tatctatatt tttaattttt tctatgtatt
    15961 tatcaattga atcatcaaca cctatatatc ttgtaaagta gacttcttta atatatgaag
    16021 aactcttatt tttataggta gtatcagata taaattcaat tagaggttca gtagactttt
    16081 ttattgaaat ctttaatggt ttaatagtac aaatcatatt ttttctccta taataagatg
    16141 atataatcta ttataaaaca acttaaaaca atatagtaca ataattttgt agtttcaaaa
    16201 taaaatatgt acttgtttat ataaatgata tataattaca ataaaattgc cgaaaagccc
    16261 tctcctttag gtgta
//
LOCUS       DAEHWM010000245        15199 bp    DNA     linear   BCT 02-JUN-2021
DEFINITION  TPA_asm: Clostridioides difficile strain Symptomatic Infection 2471
            SAMN04459214-rid12358533.guided.101, whole genome shotgun sequence.
ACCESSION   DAEHWM010000245 DAEHWM010000000
VERSION     DAEHWM010000245.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN04459214
            Sequence Read Archive: SRR3339008
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Clostridioides difficile (Clostridium difficile)
  ORGANISM  Clostridioides difficile
            Bacteria; Bacillota; Clostridia; Peptostreptococcales;
            Peptostreptococcaceae; Clostridioides.
REFERENCE   1  (bases 1 to 15199)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15199)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUN-2021) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 01-JUN-2021
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001055459.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001055459.1
            Genome Coverage       :: 65x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 06/01/2021 05:51:23
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 3,879
            CDSs (total)                      :: 3,796
            Genes (coding)                    :: 3,747
            CDSs (with protein)               :: 3,747
            Genes (RNA)                       :: 83
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 15 of 49
            Pseudo Genes (incomplete)         :: 26 of 49
            Pseudo Genes (internal stop)      :: 18 of 49
            Pseudo Genes (multiple problems)  :: 9 of 49
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15199
                     /organism="Clostridioides difficile"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN04459214-rid12358533.guided.101"
                     /strain="Symptomatic Infection 2471"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:1496"
                     /country="United Kingdom: Leeds"
                     /collection_date="2012-05-11"
                     /collected_by="Leeds Teaching Hospitals NHS Trust"
     gene            278..1231
                     /gene="blaCDD"
                     /locus_tag="KNP36_003868"
     CDS             278..1231
                     /gene="blaCDD"
                     /locus_tag="KNP36_003868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434692.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDD family class D beta-lactamase"
                     /protein_id="HBF0875640.1"
                     /translation="MKRKKNFIWIAILLVGVVMVMYYVGKKHNDINQKTDKNYIKSEL
                     NKSELNKSKIENNNKNKKEKINMVDYSDCFEGISGGAIFYNTKNKEYNIYNKELIETR
                     RSPCSTFKIVSTLIGLEKGVINSKESVMGYDGTEYPNKNWNKNLSLEEAFKESCVWYY
                     KKLIDKVDAKSVQNILDDLKYGNCDISEWEGDLKNGKGHLNGFWLESSLQISPKEQVQ
                     TMAKIFEGDTNFKKEHINILRDIMKIDVNDKNINVYGKTGTGFDEKNKRVDAWFVGML
                     EREGDTYYFAIKSDDSNKEITGPKVKEIAINIIKKYYSVRE"
     gene            1575..2258
                     /locus_tag="KNP36_003869"
     CDS             1575..2258
                     /locus_tag="KNP36_003869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HBF0875641.1"
                     /translation="MEILKCENLTKIYGSNQTRVTALNNVNLSVQKGDFVSIVGASGS
                     GKSTLLHLLGGVDRPTSGKIYVEDTEISSLKEEALAVFRRRKVGLIYQFYNLIPTLDV
                     RKNILLPMLLDKRKVDEDRFSEIVSILGLSDRLNHLPSQLSGGQQQRVSIARSLIYRP
                     AILLADEPTGNLDRKNSEEIVDLLNLSNKRFNQTILLITHDEKIALEANRIVTMEDGV
                     IVSEKVVKK"
     gene            2255..4915
                     /locus_tag="KNP36_003870"
     CDS             2255..4915
                     /locus_tag="KNP36_003870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HBF0875642.1"
                     /translation="MNILQEYTLDFVRRNKRSSIAIMLAILLTTTMMSSLCGLLYTMW
                     TDFIKLSIEKEGNWHGELFDYTYGSDLPLIENFSSVDDVMVKGQWYVGKINDEKRDYI
                     IYRNATSEYWNSMPEKDTIIEGRRPNNANEIALSKQYFENNPSVKIGDKITLPIGDRI
                     LNGKPLEPIAPKSKGESFKKISEATLTIVGKVDVSTSSVIPAYTALGYLDKTSIKPND
                     SITVYLRFKNIRDTYKELPKLAKSLGWKTNEYGKYNLKYNSNYLLKMLVFSPEQKASM
                     SSISKFSTPIMYLTIAIFTVAVFVMVIYNAFSLSANARLTQLGILSSVGASPKQIKRS
                     VVFEGFLLTIIPLPIGLFLGWLLCNRLIVYVNSVNYHTDVPEVVFTYGIPAFLPAVLL
                     TIVTVWISALIPARKVSKISPIEAIRQGDSVKIKKSHKYSLGKIFGIEGELASNALRA
                     RKKSYRTATISLTLSFLLLTCFLHIIANQEGAKAVYGSDNYKDQRDIAVYLENSEPVE
                     SAFIEKLDNTEGVKSSLYYQKMSASTWLTEKDASKELAKNGGFKNIASSKKYSPIERD
                     GKFRIISNIIGLDDKSFTEYCRQISVDPKLFYDTKNPTSIVYNKEEDINRSTRRNKVY
                     IDYLNLSIGDNIKLNEKVYDEDKGDYTYNMKVGAITSTLPKIVDTSSKYTLMQIVPMS
                     MVQEISKNYDEVSRLRSNRLIGVFKVNNREDIPRVREKLESIYNKDYGSGDYSIEDVL
                     ESEKQKASGIKTMNLIVGFITGLLAMIGLSNVLATVSGNIRSRRQEFAMLRSVGLSPE
                     GIKKMLILEGLFLGITPLLLSIPVQIGIVYAFLRINEIYFIEYLPFAPISTIIGFTIL
                     ILFIVIASYMTGYKQLKNENIVESIKNETI"
     gene            complement(5096..6277)
                     /locus_tag="KNP36_003871"
     CDS             complement(5096..6277)
                     /locus_tag="KNP36_003871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HBF0875643.1"
                     /translation="MKTPRNINSTVVFIIFCLIVTFLLSVILTTITSFNEYNVLSKAL
                     GASYEYNPKSTESILKSLKNSSDKDFKTGNEILSKHGYSKSTFWSKNFFYFLVISFGI
                     ISTMATVVYIIKHRTNKQKLSRINNLTQYLEEVNLGKESVLLRCEDEFSHLEDEIYKT
                     VGELRCSKEFALKERQTLSDNLADIAHQLKTPITSMSLMAQLLSENCPDEEIDYINRL
                     TNQISRLERLVSSLLTLSKLDASTLIFESKLIDVHSLLTYAIEPIEGSLREKHQTFTI
                     EASPSVEFEIDINWTLEALLNILKNCSEHIEDGGYIVAYYSQNPLYVEIIIEDNGKGF
                     AQEELPYIFNRFYRGKNASKDSIGIGLALSKSIIERQNGTLHAENCHNGGARFIIKFY
                     T"
     gene            complement(6277..6939)
                     /locus_tag="KNP36_003872"
     CDS             complement(6277..6939)
                     /locus_tag="KNP36_003872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009901935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HBF0875644.1"
                     /translation="MAKILLLEDNDTITFGIKTSLEKKNHTVCCYNTIAEAKKNFDKT
                     IDLILLDLNLPDGIGYEFCQYVKSIEDTPVIFLTVRDDEKDIIRGLDMGADDYVVKPF
                     LLSVLQSRINAVLRRTHSNTNNTITCENISLNKVEVKAYLDNVEVPLTAGEYKLLLSL
                     MENKNRAMTRTKLLEMLWDVDGNFVNDNTLTVTIKRLREKLKNPPCIKTLRGIGYRME
                     DN"
     gene            complement(7071..7709)
                     /locus_tag="KNP36_003873"
     CDS             complement(7071..7709)
                     /locus_tag="KNP36_003873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003417472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HBF0875645.1"
                     /translation="MSELSKRDKEKIQRENEIIDKAEKLFCLNGFDNTTMNELAKEVE
                     YTKRTIYKYFSCKEDLFFAVVLRGYKRLWDNVKIESAKGKTGFEKIKLSYFAFHKFYS
                     VEPSLLCLMGMIGIVNSEKSDTDMLFKEKFFSFNKFMFDEIQGMFEIGKNDRSIRHDI
                     EIPTLMYSSIFTLTGFFNLLSVTGKSYLNNFNIDEEKFIETTLALLIDSIKA"
     gene            7888..8493
                     /locus_tag="KNP36_003874"
     CDS             7888..8493
                     /locus_tag="KNP36_003874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HBF0875646.1"
                     /translation="MKIKENVLMLDSTRGSNCFIVFDKEIILIDTGLPFMGKNIIKEL
                     KTLGIKLTDIKHILLTHHDVDHISNIKLLKEKTGAKVWAHVEDIPFIIGEKDRPGFKK
                     FIGKAISRRLIKDVEPYGENMQIGNIKIIHTPGHTPGHVCMIFEDVLFAGDLVKNKNG
                     NIVPYPNPWNWDYKKMMKSIRELDNLKYEWICMSHGTPCIK"
     gene            8997..9746
                     /locus_tag="KNP36_003875"
     CDS             8997..9746
                     /locus_tag="KNP36_003875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0875647.1"
                     /translation="MRLESLVNQNYDNLNENDKIIIKQILICQREYRNFSCEKIANEC
                     NVSRATLLRLCRKIGLDSFSDLKYLLKNNQLEFVNNDNNFHDVCENYRLLMNELQKIS
                     FQDICKIIYDAETIYIYGTGNEQKSLAQEIKRIFLSVGKCVIDLFDIGEIEFMRESFQ
                     KSDLFIIISLSGETKAGIEIAKFINNHIHTISLTRLDNNTIATLCEYNLYVETQKLDT
                     LQAISYEVVGAFYALLDLLHMNYIEYRRRKE"
     gene            9743..10507
                     /locus_tag="KNP36_003876"
     CDS             9743..10507
                     /locus_tag="KNP36_003876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003434714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HBF0875648.1"
                     /translation="MKIEGLFNKYYNSFTANDKYICECILNHKEDCIKLSIDEFADKY
                     HISTSALSRFAQKLQLPGYSELRVIIRLNETEVEYKNQSKHQLMDCYNKVINDIEKKD
                     CSIMFERMKKANRIIVFGEGYSQERVAKEMKRIFLPTGKIIYDVYGYDMIQALNHFIK
                     TDDMIFFISLNGDASTIIDFAKEMRMKGIYMVSITKMISNPLARLCDENLYIQSISIS
                     VDKQLDYDVTTPYFILIELLYIKYKMYLESEHIPRK"
     gene            10606..11427
                     /locus_tag="KNP36_003877"
     CDS             10606..11427
                     /locus_tag="KNP36_003877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HBF0875649.1"
                     /translation="MKLYKLLILDIDGTLRDEVYGIPESAKHAIRLCQKNHCSVVICT
                     GRSMGTIQDDVLSLGVDGYIAGGGNYIQYHGELLYNQSFNQRLIKEVVCLLKNREVAF
                     SIESQEKVFMNQKAKEIFETMNQLKGTNSCINKQHIQEKITYENNIEEYKSQDIHKIC
                     LWSNEKVFDEVKDILQDKMELAQRDISSQYYEIIQKDFHKGKAIKRLQERLGVTQKET
                     ICFGDGQNDIVMFQASDVTIAMKNSHQQLKDIATSICEDIFDNGIYKELKRRNII"
     gene            11441..13105
                     /locus_tag="KNP36_003878"
     CDS             11441..13105
                     /locus_tag="KNP36_003878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003426300.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HBF0875650.1"
                     /translation="MEKKWWQKEIVYQIYPRSFQDSNNDGIGDLQGIISRLDYLKDLG
                     ITSLWLCPIFKSPMDDNGYDISDYLDIASEFGSMEDLKELIKKSKDRGIKIILDLVLN
                     HTSDEHPWFQEALKNPESPYHDYYIFKKGNDLPNNWRSVFGGSVWEKVENRDEYYFHS
                     FGKKQPDLNWENPILRSELYQMINTWSQMGVAGFRVDAITFIKKNLSFQSLESDGVDG
                     LVKCTKTVRNQPGIEKMLYELKENTFKKYDCMTVAEAAGISYDQLGDFIGEDGFFSMV
                     FDFKHADLDVASGSEWFKRISWTIPDLRKCILDSQMYVQEHGWAANFIENHDQPRATT
                     KYLLQYERNDDAVKMLGAMYFFLRGTPFIYQGQELGMTNFKRDTINDFNDLSSIDQYY
                     RSIDEGYSEEEALEFVNLRSRDNARTPFPWADKENAGFSDTTPWLKVIENYKDINAQS
                     QINNSESILEFYKKMIKLRQDSEYSDCLIYGSIEPIDIESDDIIAYRRQLDLVVIDCY
                     YNFSDKPVEIRVEEKYDIVFQNLDDINLLNKTVRLKPFHAVLLKVR"
     gene            13110..14984
                     /locus_tag="KNP36_003879"
     CDS             13110..14984
                     /locus_tag="KNP36_003879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009888302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HBF0875651.1"
                     /translation="MNKYNKIANELIKIIGEDNIISITHCATRLRVMVKDREIINDKK
                     VEKVDEVKGVFFTSGQYQIILGTGIVNKVYAEVEKMGLKTLSKKEQDELVKNNETGFK
                     KVMRTLADIFVPIIPVIAATGLFLGLKGCLFNDNVLGLFGMSSANIPLYIQTLVSVLT
                     ETAFAFLPAIIVWSAFKVFGGTPVIGLVIGLMLVSPILPNAYSVADPSNEIEAIMAFG
                     FIPIVGCQGSVLTAIVTAFIGANLEKWFRKHMPNVLDLIFTPFFVMLITMLVILLGVG
                     PIMHTIELKMVDIISLLIDLPLGIGGFIIGFTYPLAVITGLHHTYVMIETSLLANTGF
                     NALITLCAMYGFANIGTCLAFMKKSKNNQVKQTAVGAMLSQLFGISEPVLFGIQLRYN
                     LKPLIIMCASSGLGAAILSILHIQSNSYGLAVLPSYLMYIYDGYNLITYLLASIFVVA
                     FCFIVTCLFGVPKEAINEDEDEELVFNENNENFVSPAKGKIVALENVPDETFSKKMLG
                     DGFAIDIIDGKIVSPISGKLETVVSSGHAFGIKGTNGEVLIHVGIDTVALNGDGFDIA
                     VKQGDMVKQGDVLVNVDLKRIHELGKSTLTMVLFPDGKKVNILDINKDVKIGQRICVE
                     "
BASE COUNT         5709 a         1744 c         2526 g         5220 t
ORIGIN      
        1 attgtaatat ttaaatatta caatagtaag ttttaaatgt ggaatcaatt attatatcac
       61 aaattaaaag gaggacagga tgttattaat agttacttaa ttatcttcgc aataggttta
      121 atcaacataa ttgtactagg tgaagaaaat ataagagata cagctattca tttagtcttg
      181 tttcttataa gtagaaccta gattggagta tattacaaat aatgtctact attttaatag
      241 taggttataa atttaaatat gggagatgat ataaattatg aaaagaaaaa agaattttat
      301 ttggatagct atcttattgg ttggtgtagt tatggtaatg tattatgtag ggaaaaaaca
      361 taacgatata aatcaaaaaa ctgataagaa ttatataaaa tctgaattaa ataagtctga
      421 attaaataaa tccaaaattg aaaacaataa taaaaacaaa aaagaaaaaa ttaatatggt
      481 tgactatagt gattgttttg aaggtattag tggaggagct attttttata atactaaaaa
      541 taaagaatat aatatatata acaaagaatt aattgaaaca agaaggtcac catgttctac
      601 ttttaaaata gtttcaactt taattggttt agaaaaaggg gtaataaact caaaagaatc
      661 agttatggga tatgatggta cagagtatcc aaataaaaat tggaataaaa atcttagttt
      721 agaagaggca tttaaggagt cttgtgtttg gtactacaaa aaattgatag ataaagttga
      781 tgctaaatct gtccaaaaca ttttagatga tttaaagtat gggaattgcg atattagcga
      841 atgggaagga gatttaaaaa atggaaaggg acatttaaat ggattttggt tagaatcttc
      901 attacaaata tctccaaaag aacaagtgca aacaatggca aaaatatttg agggagatac
      961 aaactttaaa aaagagcata ttaatatttt aagagatatt atgaaaatag atgtaaatga
     1021 taaaaacata aatgtatatg gaaaaactgg aacaggattt gatgaaaaaa ataaacgtgt
     1081 ggatgcatgg tttgttggta tgctagagcg tgaaggtgac acctattatt ttgctattaa
     1141 atcagatgat tccaataaag aaattacagg gccaaaggta aaggaaattg caattaatat
     1201 aattaagaaa tattatagtg taagggaata aacttaattt tatttgtaaa tattatttac
     1261 ctatagtctg taatatttat taaataattt tactaaattg agtctatata gagcaaaact
     1321 cctttagtac ataaaatact tgctattgat tattaaattg aatacctata gatttaaagt
     1381 taataccttt taaagactat gtaatatatt aaaagtataa ataaaatata ttgcatagtt
     1441 tttgttttat attataattt taaataatgt gcaaaaacta aacaatattt ttaatagtaa
     1501 tttatatttg tattcatgtc actataatgt cattttaggt tgctaaaatt taaccataaa
     1561 ggagatgatt gtatatggaa atattaaaat gtgaaaatct cacaaaaata tatggttcaa
     1621 atcaaaccag agtgacagcc cttaataatg taaatttatc agttcaaaaa ggtgattttg
     1681 tatccattgt aggagcatct ggttctggca aatctacatt gttacatctg cttgggggag
     1741 tagatagacc tacatctgga aagatttatg ttgaagatac agaaatatca agtttaaagg
     1801 aagaagctct tgcagttttt agacgtagaa aagtaggtct tatttatcaa ttttataatc
     1861 ttatacctac ccttgatgtt agaaaaaata tattattacc catgttactt gataaaagaa
     1921 aggtggatga ggatagattc tctgagattg tatctatatt gggattatct gatagattaa
     1981 accatcttcc aagtcaactt tcaggtggac aacaacaaag ggtatctata gctagaagtt
     2041 taatctatag accagctatt ttattagcag atgagccaac tggtaatctt gatagaaaaa
     2101 attcagaaga aattgtagac ttgttaaact tatcaaataa acgatttaat cagacaatac
     2161 ttcttattac tcatgatgag aaaatagcac tagaggcaaa tcgtattgta actatggaag
     2221 atggagtgat tgtctctgaa aaggtggtga agaaatgaat attcttcaag aatacacctt
     2281 agactttgta cgacgcaata aacgtagtag tatagctata atgttagcta tattacttac
     2341 tacaaccatg atgtcttctt tgtgtggact gttgtatacc atgtggacag attttataaa
     2401 actttcaatt gagaaagaag gtaactggca tggtgaattg tttgactata cttatggaag
     2461 tgacttacca ttaattgaaa atttttcttc agttgatgat gtaatggtaa aaggacaatg
     2521 gtatgtaggc aaaattaatg atgagaaaag agattatata atttatagaa atgctacatc
     2581 agagtattgg aattctatgc cagaaaagga tactataata gagggtcgtc gaccaaataa
     2641 tgctaatgaa attgcattat caaaacaata ttttgagaat aatccaagtg taaaaattgg
     2701 tgataaaatt actctcccaa taggagatag aatcctaaat ggaaagcctc ttgaacccat
     2761 agccccaaaa tcgaaagggg aaagttttaa aaaaatttca gaggctacat tgacaatagt
     2821 aggaaaggta gatgtttcta cttcatcagt aatacctgca tatacagctc ttggatatct
     2881 tgataaaaca agtataaaac ctaatgatag tataactgtg tacttgcgat ttaaaaatat
     2941 aagagacacg tataaggaac ttccaaaact tgctaaatca ttgggatgga agactaatga
     3001 atatggaaaa tacaatctta aatacaatag taattatctt ttaaagatgt tagtcttttc
     3061 accagaacag aaagcatcta tgagtagtat atcaaaattt tcaactccta ttatgtatct
     3121 tacaatagca atttttacag tagccgtgtt tgtaatggtg atttacaacg cgttttcact
     3181 gtctgcaaat gctagactta ctcaattagg gatattatct agtgttggtg catcaccaaa
     3241 acaaattaaa aggtctgtag tgtttgaagg ctttttactg acaattatac cattaccaat
     3301 aggtttattt ttaggatggt tattgtgtaa taggcttata gtttatgtta attcagttaa
     3361 ttatcatact gatgttccag aagtggtatt tacttatggt attcctgctt ttctgccagc
     3421 agttttactt acaatagtaa cagtctggat ttctgcactt ataccagcac gaaaagtatc
     3481 aaagatatct cctatagaag caatacgaca aggagatagt gttaaaatca aaaagtcgca
     3541 taaatattca ttaggaaaga tatttggaat agaaggagaa cttgcatcaa acgcactacg
     3601 tgctcgtaaa aaatcttatc gtactgcaac aatatcttta acattatctt ttttattact
     3661 tacatgtttt ttgcatataa ttgcaaatca agaaggagca aaagctgttt atggaagtga
     3721 taattataag gaccaaagag atatagcagt ttatttggaa aatagtgaac ctgtagagtc
     3781 tgctttcatt gaaaaattag ataatacaga aggtgtaaaa agttcactat attatcaaaa
     3841 aatgtctgct tccacttggt tgactgaaaa agatgcttca aaagaacttg cgaaaaatgg
     3901 aggatttaaa aatatagctt catctaaaaa gtactctcct atagaacgtg atggcaagtt
     3961 tcgtataatt tcaaatataa ttgggcttga tgataagagt tttacagaat attgtaggca
     4021 aatttctgta gacccaaagt tattttatga tacaaaaaat ccaacctcaa ttgtatataa
     4081 taaggaggaa gatattaatc gtagtacacg tagaaataaa gtatatatag attatttaaa
     4141 tctttcaata ggagataaca ttaaattaaa tgaaaaagta tatgacgaag ataaagggga
     4201 ttatacttac aacatgaaag tgggagctat tacaagcaca cttcctaaaa tagtagatac
     4261 tagttcaaag tatacattaa tgcaaatagt tccaatgtct atggtgcagg aaatatctaa
     4321 aaattatgat gaagtaagta ggttacgttc aaataggctg ataggagtat ttaaagtaaa
     4381 taatcgtgag gacattccta gagtaagaga aaaattagag tccatttata ataaagacta
     4441 tggttcagga gattatagta ttgaggatgt tttagaaagt gaaaaacaaa aggctagtgg
     4501 aataaagacc atgaatttaa tagtaggctt tattacaggt ttattggcta tgattggatt
     4561 atcaaatgta cttgctacag tgtcaggaaa tattagaagt agacgacaag agtttgctat
     4621 gttgcgttct gttggattat ctccagaagg cataaaaaag atgcttattt tggaaggttt
     4681 attcttagga attacaccat tactacttag tattcctgtg caaataggaa tagtgtatgc
     4741 ttttctacgt ataaatgaaa tatattttat agagtattta ccatttgcac ctatatctac
     4801 aataataggt tttactatat tgatactttt tattgtaata gcatcatata tgacaggata
     4861 caagcagttg aagaatgaaa atatagtaga atctataaaa aatgaaacaa tataaacaaa
     4921 atctatttga acttatttaa aggtttcgat ttaagactac ttacaagtat agggatagtt
     4981 aagttgtttg tttaataaaa ccttaaatgt aaatagaagt atattactaa aacaatagat
     5041 aacatagaat atagatatag ctggattata ggtattttac ctataatcca gcattttatg
     5101 tgtaaaattt aattatgaat cttgcaccac cattatggca attttctgca tgtagagtac
     5161 cattttgacg ttctataata gactttgata gagcaagccc tataccaata ctgtccttac
     5221 tagcattttt accacgataa aatctattaa aaatatatgg aagttcttcc tgagcaaacc
     5281 ccttaccatt atcttctatg ataatctcaa catatagagg attttgacta taataagcaa
     5341 ctatatatcc accatcttct atatgctcac tacaattttt aagaatattt aaaagagctt
     5401 ctaaagtcca attaatatcg atttcaaatt ctaccgaagg agaagcctcg atagtaaatg
     5461 tctgatgttt ttctcttaaa gaaccttcta taggctcaat tgcataagta agaagagaat
     5521 gtacatctat aagtttgctt tcaaatatta aagtacttgc atccaatttt gataatgtaa
     5581 gtaaagatga aactagtctc tcaagtcttg agatttgatt tgtaagtctg ttaatataat
     5641 ctatttcttc atctggacaa ttttctgaaa gtaattgtgc cataagtgac atagaggtaa
     5701 ttggagtctt aagttgatga gcaatatctg caaggttatc tgaaagagtt tgtctttctt
     5761 ttaaagcaaa ttcttttgaa caacgaagtt ccccaactgt tttatatatc tcatcttcaa
     5821 ggtgagaaaa ttcatcttca catcgtaaaa gtacagactc ttttcctaaa ttcacttctt
     5881 ctaagtattg agtaagattg tttattctac tcagtttttg cttatttgtt ctatgtttga
     5941 ttatatatac aactgtagcc attgttgaaa ttataccaaa cgatatcact agaaaataaa
     6001 aaaagttttt actccaaaat gtacttttag aatatccatg ttttgataaa atttcatttc
     6061 ctgttttaaa atccttatca ctagaatttt tcagtgattt tagtatactt tctgtagact
     6121 taggattgta ctcatatgat gcaccaagag ccttagacag tacattgtat tcattaaaag
     6181 aagttatagt tgttagaatt acactcaata aaaaagttac aattaagcag aatattataa
     6241 aaacaactgt actgttgata tttcttggag ttttcactag ttgtcctcca ttctatatcc
     6301 tatgcctctt aatgttttta tacaaggtgg attttttaat ttttctctaa gacgttttat
     6361 tgtaacagta agagtgttat catttacgaa attaccatct acatcccaga gcatttctag
     6421 taactttgta cgagtcatag ctctattttt attttccata agacttagaa gaagtttata
     6481 ttctcctgct gtcaaaggta cttcaacatt atctaaatat gctttgactt caaccttatt
     6541 caagcttata ttttcacatg taatagtatt gttagtattt gaatgagttc ttctaagaac
     6601 tgcattaatt ctggattgaa gtactgagag caaaaacggt ttaaccacat agtcatctgc
     6661 acccatatct aatccacgta taatgtcttt ttcatcatca cggactgtca aaaatatcac
     6721 tggagtatct tctatacttt taacatattg gcaaaactcg tatccaatac catcaggtag
     6781 atttaaatca agcagaatta aatcaatagt tttatcaaaa ttttttttag cttcagcaat
     6841 cgtattataa caacatacag tgtgattttt cttttcaagg gaagttttta ttccaaatgt
     6901 aattgtatca ttatcttcta aaagaagtat tttagccatt tacttttaat cctttcagta
     6961 atttagttat tccattaact aagttattag ttttatgttt aatatttttc atattagaga
     7021 tagaaaaaat tatcatttaa gtatataaac tttaatttat aaacttaggt ttatgcttta
     7081 attgaatcta ttaaaagagc aagagttgtt tcaataaatt tttcctcatc tatattaaag
     7141 ttgttcaggt atgattttcc tgttacagat agtaaattaa aaaatcctgt aagtgtaaat
     7201 attgatgaat acataagagt aggtatttca atatcatgcc taatacttct atcatttttt
     7261 ccaatttcaa acattccttg tatttcatca aacataaatt tattaaaaga aaaaaacttt
     7321 tctttaaaca gcatatcagt atccgatttt tcagagttta caataccaat cattcccata
     7381 aggcataata gagaaggttc tacagagtaa aatttatgaa aagcaaagta tgaaagtttt
     7441 attttttcaa accctgtttt gccttttgca ctttctattt taacattatc ccaaagtctt
     7501 ttatatcctc ttaagacaac agcaaagaat aaatcttctt tacatgaaaa gtacttgtat
     7561 atggtgcgtt tagtatattc aacttctttt gctaattcat tcatagttgt attatcaaat
     7621 ccattaagac aaaataattt ttctgcctta tcaataatct cattttctct ttgtattttt
     7681 tctttatctc tttttgataa ttctgacata taaattattc ctttctattg ataaaaaagt
     7741 atactgatgg tatatttatg taaatataat atttgtatac ctatagtata ctttaataaa
     7801 aaataaaatt aatatcaagt attataacta tttataactt tattaattaa ttatataggt
     7861 aaaataccaa ataaggggaa tttatttatg aagataaaag aaaatgtatt aatgttagat
     7921 agtactcgtg gctcaaattg ttttattgtg tttgataaag aaattattct tatagacaca
     7981 ggtcttcctt ttatggggaa aaatataatt aaagaattaa aaacacttgg cattaaactt
     8041 acagatatta agcatatttt attaactcat catgatgttg accatatatc taatattaaa
     8101 ttattgaaag aaaaaacagg agcaaaagta tgggctcatg tagaggatat accttttatt
     8161 ataggagaga aggatagacc tgggtttaag aagtttattg gaaaggcaat ttccagaagg
     8221 ctcattaagg atgttgaacc ttatggagag aatatgcaga ttgggaatat aaaaattatc
     8281 catactcctg gtcatactcc agggcatgtc tgcatgattt ttgaagatgt attatttgca
     8341 ggtgatttag tcaaaaataa gaatggaaat atagttcctt atcctaatcc atggaattgg
     8401 gattataaaa agatgatgaa atctataaga gaattggata atttaaaata tgaatggata
     8461 tgtatgtctc atggaactcc ttgtattaaa taataaaaat taacatggat taatagaggc
     8521 gtagttgctt gtatgtatga taataattta cagcttcttt ttaatatatc atgtatattt
     8581 gtagctgtaa gcatatttat aacaatactt acaattttgt attttaacat ctataataat
     8641 aattttagct ttgttaacta tgaaatttac ttaaagaagt aaatattcaa gtagtagtaa
     8701 ttattaaata agataaaaaa taaatggcag atgaattaaa gtaatttcta ccatggaaaa
     8761 tacttttgag ttagaaaaaa ctctatttta gagtatgaag agatgaagct tccgaagaaa
     8821 gcaatatcta aagtacatgt tcgaaaggat aagtactttt tggtgcctgc ttttagcagg
     8881 ttatttttat tttaataaaa ataaaatcaa atgattattt tatccttatt atttaaaact
     8941 cttccctaga aaaagcaact aatgtatatt aaaataatat ttagggagtg gaaaaaatga
     9001 gattagaatc gttagttaac caaaattatg ataatttaaa tgaaaatgat aaaattatta
     9061 ttaaacaaat attgatttgt caaagagaat accgtaattt ttcgtgtgaa aaaattgcaa
     9121 atgaatgtaa tgtttctaga gctactttat taaggctttg tagaaaaatt ggattagatt
     9181 cattctctga tttaaagtat ttacttaaaa ataatcaact agaatttgtt aataatgata
     9241 ataattttca tgatgtttgc gagaattatc gactattaat gaatgaatta caaaaaatat
     9301 catttcaaga tatttgtaaa ataatatatg atgcagaaac aatttatatt tatgggacag
     9361 gtaatgaaca gaaaagttta gctcaagaaa taaagagaat atttctttca gtaggtaaat
     9421 gtgttattga cttatttgat ataggtgaaa ttgaatttat gagagaatca tttcaaaaaa
     9481 gtgatttatt tattatcatt tctttgtctg gagaaacaaa agcaggaatt gaaattgcaa
     9541 aatttatcaa caatcatata catacgattt ctttaactag gcttgataat aatacaattg
     9601 caacactttg tgagtataat ctgtatgttg aaactcaaaa acttgataca ttacaagcta
     9661 tatcttatga agtcgtagga gcattttatg ctctattaga tttgcttcat atgaattaca
     9721 tagagtatag aaggagaaaa gaatgaaaat tgaaggactt ttcaataaat attataattc
     9781 atttacagca aatgataagt atatctgtga gtgtattctt aatcataaag aagattgtat
     9841 taaactttct atagatgaat ttgcagacaa ataccatata tctacaagtg cactttctcg
     9901 ttttgctcaa aaactacaat tacctggata tagtgaatta agagttatta tacgcttaaa
     9961 tgaaacagaa gtagaatata aaaatcaaag taaacaccaa ttaatggatt gctataataa
    10021 ggtgataaat gatatagaga agaaggattg ttcgattatg tttgaaagaa tgaaaaaggc
    10081 aaatcgtata atcgtctttg gagaaggtta ttctcaggaa agagttgcta aagagatgaa
    10141 aaggattttc ttaccaacag ggaaaattat atatgatgtt tatggttatg atatgattca
    10201 ggcacttaat cattttataa aaacagatga tatgattttc tttatttcat tgaatggaga
    10261 tgcatctaca attattgatt ttgctaaaga aatgagaatg aaaggaattt atatggtttc
    10321 tattacaaaa atgataagta atcctttagc aagattatgt gatgaaaacc tgtatattca
    10381 atctatatct atttctgtag ataaacaact ggactacgat gtaacaacac cttattttat
    10441 tttaattgaa ctgctttata ttaaatacaa gatgtattta gaaagtgaac atattccccg
    10501 aaaatgaaaa tttgtgctaa aaatgaacat attttttaaa agatatcaaa atattgatat
    10561 cttttttttt gaatgctatt atgattttga tagtaagaaa ggaagatgaa attgtacaaa
    10621 ttattaatac ttgatataga tggtacgctt agagatgagg tatatggaat cccagaatct
    10681 gcaaagcatg ctatacgttt atgtcaaaag aatcattgca gtgttgttat ttgtactgga
    10741 agaagtatgg gtacaataca agatgatgtt ttatcattag gagttgatgg atatattgca
    10801 ggaggaggta attacattca atatcatggt gaattacttt ataatcaatc ttttaatcaa
    10861 agattgataa aggaagttgt ttgtttatta aaaaatagag aagttgcttt ttcgattgag
    10921 agtcaggaaa aagttttcat gaatcaaaaa gccaaagaaa tatttgaaac aatgaatcag
    10981 ttgaaaggaa ctaattcttg tataaataaa caacatatcc aagaaaaaat aacatatgaa
    11041 aataacattg aagagtataa gtcacaagat atacataaaa tttgtttatg gtcaaatgaa
    11101 aaggtatttg acgaagtgaa agatatacta caagataaaa tggaattagc acagagagat
    11161 atttctagtc agtattatga aattattcaa aaagattttc ataagggcaa agcaattaag
    11221 agattacaag aaagattagg agtaactcaa aaagaaacca tatgttttgg tgatggtcaa
    11281 aatgacattg tcatgtttca agcatcagac gttacaattg caatgaaaaa tagtcatcaa
    11341 caacttaaag atatagcgac atctatatgt gaggacatat tcgataatgg aatttataaa
    11401 gaattaaaaa gaagaaatat catataaaaa ggagtaattt atggaaaaga aatggtggca
    11461 aaaagaaatc gtttatcaaa tttatccaag aagctttcaa gatagtaata atgatggaat
    11521 tggagattta cagggaatta tttctcgttt agattattta aaagatttag gtattacatc
    11581 attgtggtta tgtccaattt ttaaatcacc tatggatgat aatgggtatg atattagtga
    11641 ttatttggat attgcaagtg aatttggaag tatggaagat ttaaaagagt taattaaaaa
    11701 aagtaaagat agaggaatca aaattatatt agatttagtt cttaatcata caagtgatga
    11761 acatccttgg tttcaagaag cattaaaaaa tccagaaagt ccttatcatg attattatat
    11821 ttttaaaaaa ggaaacgatt tgccaaataa ctggaggtct gtttttggtg gaagtgtttg
    11881 ggaaaaggta gagaatagag acgaatatta ttttcattct tttggaaaaa aacaacctga
    11941 ccttaattgg gaaaatccaa tattaagaag tgaactttac caaatgatta atacctggtc
    12001 tcaaatggga gtggcaggat ttagagttga tgctattaca ttcatcaaaa agaatttaag
    12061 ttttcaaagt ttagaaagtg atggtgttga tggtcttgtt aaatgtacaa aaacagttag
    12121 aaatcagcct ggaatagaaa aaatgcttta tgaattaaaa gaaaatacgt ttaaaaaata
    12181 tgattgtatg actgttgctg aagcagcagg tattagctat gaccagttag gtgattttat
    12241 tggagaagat ggtttctttt caatggtctt tgactttaaa catgctgact tagatgttgc
    12301 ttctggtagt gagtggttta aaagaatttc atggacaatt ccagatttaa gaaaatgcat
    12361 tttagatagt caaatgtatg ttcaggaaca tggatgggca gctaatttta ttgaaaatca
    12421 tgaccaacca agagctacaa caaagtatct tttgcaatac gaaaggaatg atgatgcagt
    12481 aaaaatgttg ggagcaatgt atttcttttt aagaggaacc ccatttattt atcagggaca
    12541 ggaattagga atgacaaatt ttaaaagaga taccataaat gattttaatg atttatctag
    12601 cattgaccaa tactatcgtt caatagatga aggttactca gaagaagaag cgttagaatt
    12661 tgtgaattta agaagccgag ataatgcaag aacgccattt ccatgggcag ataaagaaaa
    12721 tgcaggtttt tcagatacaa caccatggtt aaaggttatt gaaaattata aagatattaa
    12781 tgcacagagt cagattaaca attcagagag tattttagaa ttttataaaa agatgataaa
    12841 gttgagacaa gatagtgagt attctgattg tttgatttat ggttcaatag aacctattga
    12901 tatagaaagt gatgatatta ttgcgtatag aaggcaatta gatttggtag ttattgattg
    12961 ttattataat ttttctgata aacctgtaga aataagagta gaagaaaaat atgatattgt
    13021 attccaaaat ttagatgata taaatctatt aaataaaaca gtgcgtttga aaccatttca
    13081 tgcagtatta ttgaaagtga ggtagaaaaa tgaataaata taataaaata gcaaatgagc
    13141 ttattaaaat tattggtgaa gataatatta tttctattac acattgtgcc acaagattaa
    13201 gagtgatggt taaagataga gaaattatta atgataagaa agttgaaaaa gttgatgagg
    13261 ttaaaggggt tttctttact tctggacagt atcaaattat tttaggaaca ggaatagtta
    13321 ataaagttta tgcagaagtt gaaaaaatgg gattaaaaac tttatcaaaa aaagaacaag
    13381 atgaattagt taaaaataat gaaactggat ttaagaaagt tatgagaact ctagcagata
    13441 tatttgttcc tattattcca gttattgcag caacaggatt attcttggga ttaaagggtt
    13501 gtttgtttaa tgataatgta cttggattat ttggaatgtc ttctgcaaat attccattgt
    13561 atattcagac acttgtttcg gttcttacag aaacagcatt tgctttttta ccagcaatta
    13621 ttgtatggtc agcatttaaa gtatttggag gaacacctgt tattggactt gttattggac
    13681 ttatgttagt ttccccaata cttcctaatg catattctgt tgctgaccca tcaaatgaaa
    13741 ttgaagcaat tatggcattt ggatttattc ctattgtagg ttgtcaagga agtgttttaa
    13801 cagctattgt tacagcattt attggagcta atcttgaaaa atggttccgt aaacatatgc
    13861 ctaatgtatt agaccttatt ttcacaccat tttttgttat gctaataaca atgttagtta
    13921 ttttgttagg tgtaggccct ataatgcata caatagaatt aaaaatggtt gatatcatca
    13981 gcttattgat tgatttgcct ttaggaattg gaggatttat tattggattt acatatccat
    14041 tagctgttat tactggctta catcatactt atgtaatgat tgaaacatca ctattagcaa
    14101 atacaggatt taatgccctt attactcttt gtgcaatgta tggatttgcg aatattggaa
    14161 catgtctagc atttatgaaa aaatctaaaa ataatcaagt taaacaaact gcagttggag
    14221 caatgctatc tcaacttttt ggtataagtg agcctgtttt atttgggatt cagcttcgat
    14281 ataatttaaa gcctttgatt attatgtgtg catcttcagg tttaggagca gcaatattat
    14341 caattttaca tattcaatct aattcatatg gattagcagt tttaccttct tatttaatgt
    14401 atatctatga tggatataat ttaatcacat acttattagc atcaatattt gtggttgcat
    14461 tctgctttat tgtaacatgt ttatttggag tgcctaaaga agctataaat gaagatgaag
    14521 acgaagaatt agtgtttaat gaaaataatg aaaactttgt gtctccagct aaggggaaaa
    14581 ttgttgcatt agaaaatgta ccagatgaaa cattttctaa aaaaatgtta ggtgatggtt
    14641 ttgctattga tattatagat ggaaaaattg tttctcctat ttcaggtaaa ttagaaacag
    14701 tggtttcaag tggacatgca tttgggatta aaggaactaa tggagaagta ttaattcatg
    14761 ttggaattga tacagttgca ttaaatggag atggctttga tattgctgtt aaacaaggag
    14821 atatggttaa acagggagat gttcttgtta atgttgattt aaagagaata catgaattag
    14881 gaaagtctac tttaacaatg gtattgtttc cagatggtaa gaaggtaaat attttggata
    14941 taaacaagga tgtaaaaata ggtcaaagaa tatgtgttga gtagtaggtg atatgtaatg
    15001 actacaaaag aagattatca agagtaattc aatcttttta aagtatgaga aataattcat
    15061 aaactctaaa acaattaaag aggttgtttc aaaatagaga ttgtattgca cccaaattgt
    15121 tgaaatgatg aaaatatatt taacttcata caaaaaatta aatagtggca acaattgagg
    15181 atgtgaggga gagttgcca
//
